LOCUS 002_TFC7A_auf_Barbe 4036113 bp DNA circular CON 12-JAN-2021 DEFINITION Bacillus subtilis subsp. subtilis str. 168 complete genome. ACCESSION NC_000964 DBLINK BioProject: PRJNA76 BioSample: SAMEA3138188 KEYWORDS RefSeq; complete genome. SOURCE Bacillus subtilis subsp. subtilis str. 168 ORGANISM Bacillus subtilis subsp. subtilis str. 168 Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus. REFERENCE 1 AUTHORS Borriss,R., Danchin,A., Harwood,C.R., Medigue,C., Rocha,E.P.C., Sekowska,A. and Vallenet,D. TITLE Bacillus subtilis, the model Gram-positive bacterium: 20 years of annotation refinement JOURNAL Microb Biotechnol 11 (1), 3-17 (2018) PUBMED 29280348 REFERENCE 2 (bases 1 to 4215606) AUTHORS Belda,E., Sekowska,A., Le, Fevre,F., Morgat,A., Mornico,D., Ouzounis,C., Vallenet,D., Medigue,C. and Danchin,A. TITLE An updated metabolic view of the Bacillus subtilis 168 genome JOURNAL Microbiology (Reading, Engl.) 159 (Pt 4), 757-770 (2013) PUBMED 23429746 REFERENCE 3 (bases 1 to 4215606) AUTHORS Barbe,V., Cruveiller,S., Kunst,F., Lenoble,P., Meurice,G., Sekowska,A., Vallenet,D., Wang,T., Moszer,I., Medigue,C. and Danchin,A. TITLE From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later JOURNAL Microbiology (Reading, Engl.) 155 (Pt 6), 1758-1775 (2009) PUBMED 19383706 REFERENCE 4 (bases 1 to 4215606) AUTHORS Kunst,F., Ogasawara,N., Moszer,I., Albertini,A.M., Alloni,G., Azevedo,V., Bertero,M.G., Bessieres,P., Bolotin,A., Borchert,S., Borriss,R., Boursier,L., Brans,A., Braun,M., Brignell,S.C., Bron,S., Brouillet,S., Bruschi,C.V., Caldwell,B., Capuano,V., Carter,N.M., Choi,S.K., Cordani,J.J., Connerton,I.F., Cummings,N.J., Daniel,R.A., Denziot,F., Devine,K.M., Dusterhoft,A., Ehrlich,S.D., Emmerson,P.T., Entian,K.D., Errington,J., Fabret,C., Ferrari,E., Foulger,D., Fritz,C., Fujita,M., Fujita,Y., Fuma,S., Galizzi,A., Galleron,N., Ghim,S.Y., Glaser,P., Goffeau,A., Golightly,E.J., Grandi,G., Guiseppi,G., Guy,B.J., Haga,K., Haiech,J., Harwood,C.R., Henaut,A., Hilbert,H., Holsappel,S., Hosono,S., Hullo,M.F., Itaya,M., Jones,L., Joris,B., Karamata,D., Kasahara,Y., Klaerr-Blanchard,M., Klein,C., Kobayashi,Y., Koetter,P., Koningstein,G., Krogh,S., Kumano,M., Kurita,K., Lapidus,A., Lardinois,S., Lauber,J., Lazarevic,V., Lee,S.M., Levine,A., Liu,H., Masuda,S., Mauel,C., Medigue,C., Medina,N., Mellado,R.P., Mizuno,M., Moestl,D., Nakai,S., Noback,M., Noone,D., O'Reilly,M., Ogawa,K., Ogiwara,A., Oudega,B., Park,S.H., Parro,V., Pohl,T.M., Portelle,D., Porwollik,S., Prescott,A.M., Presecan,E., Pujic,P., Purnelle,B., Rapoport,G., Rey,M., Reynolds,S., Rieger,M., Rivolta,C., Rocha,E., Roche,B., Rose,M., Sadaie,Y., Sato,T., Scanlan,E., Schleich,S., Schroeter,R., Scoffone,F., Sekiguchi,J., Sekowska,A., Seror,S.J., Serror,P., Shin,B.S., Soldo,B., Sorokin,A., Tacconi,E., Takagi,T., Takahashi,H., Takemaru,K., Takeuchi,M., Tamakoshi,A., Tanaka,T., Terpstra,P., Togoni,A., Tosato,V., Uchiyama,S., Vandebol,M., Vannier,F., Vassarotti,A., Viari,A., Wambutt,R., Wedler,H., Weitzenegger,T., Winters,P., Wipat,A., Yamamoto,H., Yamane,K., Yasumoto,K., Yata,K., Yoshida,K., Yoshikawa,H.F., Zumstein,E., Yoshikawa,H. and Danchin,A. TITLE The complete genome sequence of the gram-positive bacterium Bacillus subtilis JOURNAL Nature 390 (6657), 249-256 (1997) PUBMED 9384377 REFERENCE 5 (bases 1 to 4215606) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (17-SEP-2018) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 6 (bases 1 to 4215606) AUTHORS Genoscope and -,C.E.A. CONSRTM AMAbiotics and Genoscope TITLE Direct Submission JOURNAL Submitted (24-JAN-2013) A. Danchin, AMAbiotics, Bldg G1, 2, rue Gaston Cremieux, 91000 EVRY antoine.danchin@normalesup.org Bldg G1 Genoscope / CEA (Commissariat a l'energie atomique et aux energies alternatives): BP 191 91006 EVRY cedex - FRANCE (E-mail: seqref@genoscope.cns.fr - Web: www.genoscope.cns.fr) REFERENCE 7 (bases 1 to 4215606) AUTHORS Genoscope and -,C.E.A. CONSRTM Institut Pasteur and Genoscope TITLE Direct Submission JOURNAL Submitted (29-JAN-2009) Genoscope - Centre National de Sequencage : BP 191 91006 EVRY cedex - FRANCE (E-mail : seqref@genoscope.cns.fr - Web : www.genoscope.cns.fr) REFERENCE 8 (bases 1 to 4215606) AUTHORS Kunst,F., Ogasawara,N., Yoshikawa,H. and Danchin,A. TITLE Direct Submission JOURNAL Submitted (18-NOV-1997) I. Moszer, A. Danchin, Genetique des Genomes Bacteriens, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, FRANCE. E-mail: moszer@pasteur.fr, antoine.danchin@normalesup.org Phone: +33 (0)1 45 68 84 41, Fax: +33 (0)1 45 68 89 48 COMMENT ##gff-version-START## gff-version :: 3 ##gff-version-END## FEATURES Location/Qualifiers S_feature 1..148 /Source="Nicolas_S_feature" /locus_tag="new_1_148" /HighExp="T0.30H, C30, T1.0H, T1.30H, T-0.40H, T0.0H, T2.0H, S2, T-1.10H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1" S_feature complement(24..297) /Source="Nicolas_S_feature" /locus_tag="new_24_297_c" /HighExp="S8, C30, Etha, S3, S7, S4, Cold, BT, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.178448" /TUshortSig="SigK, SigEF" /TUshortPSig="0.621, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S2" promotor_-35 120..124 /Source="Nicolas_upshift_promotors" /id="U1" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=2521 /SigmaFactorBS="tgtccgctttgtggataagattgtgacaacCATTGcaagctc tcgtttatTTTGGTATTATATTTGTGTTttaactcttgattactaatcctacctttcc t" /listShort="S3, dnaA, S5, dnaN, yaaA, recF" /listLong="yaaB, gyrB, S6, gyrA" /label="promotor_-35" promotor_-10 140..159 /Source="Nicolas_upshift_promotors" /id="U1" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=2521 /SigmaFactorBS="tgtccgctttgtggataagattgtgacaacCATTGcaagctc tcgtttatTTTGGTATTATATTTGTGTTttaactcttgattactaatcctacctttcc t" /listShort="S3, dnaA, S5, dnaN, yaaA, recF" /listLong="yaaB, gyrB, S6, gyrA" /label="promotor_-10" S_feature 150..409 /Source="Nicolas_S_feature" /locus_tag="new_150_409" /HighExp="Heat, G180, LPhT, G150, dia15, Oxctl, S1, G135, LBGstat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S3" upshifts 150 /Source="Nicolas_upshifts" /id="U1" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=2521 /SigmaFactorBS="tgtccgctttgtggataagattgtgacaacCATTGcaagctc tcgtttatTTTGGTATTATATTTGTGTTttaactcttgattactaatcctacctttcc t" /listShort="S3, dnaA, S5, dnaN, yaaA, recF" /listLong="yaaB, gyrB, S6, gyrA" promotor_-10 complement(285..304) /Source="Nicolas_upshift_promotors" /id="U2" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.621378621378621" /psig="0.621378621378621" /xcortree=272 /SigmaFactorBS="aacacaaaaaaagagcaaatggcgcttaccaTTCGTACACat taaatgttgaaAACATATAATATAGTAGATAaatagcttttcgacaaatttcacaact t" /listShort="S2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(297) /Source="Nicolas_upshifts" /id="U2" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.621378621378621" /psig="0.621378621378621" /xcortree=272 /SigmaFactorBS="aacacaaaaaaagagcaaatggcgcttaccaTTCGTACACat taaatgttgaaAACATATAATATAGTAGATAaatagcttttcgacaaatttcacaact t" /listShort="S2" /GFF_Attribute="listLong" S_feature complement(299..1067) /Source="Nicolas_S_feature" /locus_tag="new_299_1067_c" /HighExp="S4, LoTm, S3, C30, S5, S7, S6, T5.0H, S8, M9-stat" /AntisenseName="dnaA" /AntisenseCor="-0.57810076860528403" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S4" promotor_-35 complement(318..326) /Source="Nicolas_upshift_promotors" /id="U2" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.621378621378621" /psig="0.621378621378621" /xcortree=272 /SigmaFactorBS="aacacaaaaaaagagcaaatggcgcttaccaTTCGTACACat taaatgttgaaAACATATAATATAGTAGATAaatagcttttcgacaaatttcacaact t" /listShort="S2" /GFF_Attribute="listLong" /label="promotor_-35" CDS 410..1750 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2167836, 2846289, 12682299, 16120674, 1779750, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2167836, 2846289, 12682299, 16120674, 1779750, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosomal replication initiator informational ATPase" /protein_id="NP_387882.1" /db_xref="EnsemblGenomes-Gn:BSU00010" /db_xref="EnsemblGenomes-Tr:CAB11777" /db_xref="GOA:P05648" /db_xref="InterPro:IPR001957" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013159" /db_xref="InterPro:IPR013317" /db_xref="InterPro:IPR018312" /db_xref="InterPro:IPR020591" /db_xref="InterPro:IPR024633" /db_xref="InterPro:IPR027417" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG10065" /db_xref="UniProtKB/Swiss-Prot:P05648" /translation="MENILDLWNQALAQIEKKLSKPSFETWMKSTKAHSLQGDTLTIT APNEFARDWLESRYLHLIADTIYELTGEELSIKFVIPQNQDVEDFMPKPQVKKAVKED TSDFPQNMLNPKYTFDTFVIGSGNRFAHAASLAVAEAPAKAYNPLFIYGGVGLGKTHL MHAIGHYVIDHNPSAKVVYLSSEKFTNEFINSIRDNKAVDFRNRYRNVDVLLIDDIQF LAGKEQTQEEFFHTFNTLHEESKQIVISSDRPPKEIPTLEDRLRSRFEWGLITDITPP DLETRIAILRKKAKAEGLDIPNEVMLYIANQIDSNIRELEGALIRVVAYSSLINKDIN ADLAAEALKDIIPSSKPKVITIKEIQRVVGQQFNIKLEDFKAKKRTKSVAFPRQIAMY LSREMTDSSLPKIGEEFGGRDHTTVIHAHEKISKLLADDEQLQQHVKEIKEQLK*" gene 410..1750 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" promotor_-10 complement(1040..1058) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1066) /Source="Nicolas_upshifts" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" promotor_-35 complement(1074..1079) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1751..1938 /Source="Nicolas_S_feature" /locus_tag="new_1751_1938" /HighExp="G150, Heat, G180, G135, Paraq, Oxctl, dia0, LBGstat, S1, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S5" CDS 1939..3075 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2846289, 11395445, 12682299, 20453097, 23228104, 28878042" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846289, 11395445, 12682299, 20453097, 23228104, 28878042; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (beta subunit)" /protein_id="NP_387883.1" /db_xref="EnsemblGenomes-Gn:BSU00020" /db_xref="EnsemblGenomes-Tr:CAB11778" /db_xref="GOA:P05649" /db_xref="InterPro:IPR001001" /db_xref="InterPro:IPR022634" /db_xref="InterPro:IPR022635" /db_xref="InterPro:IPR022637" /db_xref="PDB:4TR6" /db_xref="SubtiList:BG10066" /db_xref="UniProtKB/Swiss-Prot:P05649" /translation="MKFTIQKDRLVESVQDVLKAVSSRTTIPILTGIKIVASDDGVSF TGSDSDISIESFIPKEEGDKEIVTIEQPGSIVLQARFFSEIVKKLPMATVEIEVQNQY LTIIRSGKAEFNLNGLDADEYPHLPQIEEHHAIQIPTDLLKNLIRQTVFAVSTSETRP ILTGVNWKVEQSELLCTATDSHRLALRKAKLDIPEDRSYNVVIPGKSLTELSKILDDN QELVDIVITETQVLFKAKNVLFFSRLLDGNYPDTTSLIPQDSKTEIIVNTKEFLQAID RASLLAREGRNNVVKLSAKPAESIEISSNSPEIGKVVEAIVADQIEGEELNISFSPKY MLDALKVLEGAEIRVSFTGAMRPFLIRTPNDETIVQLILPVRTY*" gene 1939..3075 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" downshifts 3059 /Source="Nicolas_upshifts" /id="D1" /incds=0 /nref=29 /ntot=161 /MaxReadThrough="5.22584" /MaxDrop="4.17087" /score="21.887269" /energy="-14.2" /TU="U1" /idTUdmin="U1" /TUdmin="-572" /isTUend="FALSE" promotor_-35 3140..3144 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3161..3180 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3169 /Source="Nicolas_upshifts" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" CDS 3206..3421 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24637032, 24939895" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24637032, 24939895; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA binding protein involved in ribosome maturation" /protein_id="NP_387884.1" /db_xref="EnsemblGenomes-Gn:BSU00030" /db_xref="EnsemblGenomes-Tr:CAB11779" /db_xref="GOA:P05650" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014330" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10067" /db_xref="UniProtKB/Swiss-Prot:P05650" /translation="MANPISIDTEMITLGQFLKLADVIQSGGMAKWFLSEHEVLVNDE PDNRRGRKLYVGDVVEIEGFGSFQVVN*" gene 3206..3421 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" CDS 3437..4549 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 16061691, 16385024, 22342069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 16061691, 16385024, 22342069; Product type f: factor" /codon_start=1 /transl_table=11 /product="RecA filament-DNA complex stabilisation, ssDNA and dsDNA binding, ATP binding" /protein_id="NP_387885.1" /db_xref="EnsemblGenomes-Gn:BSU00040" /db_xref="EnsemblGenomes-Tr:CAB11780" /db_xref="GOA:P05651" /db_xref="InterPro:IPR001238" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR018078" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10068" /db_xref="UniProtKB/Swiss-Prot:P05651" /translation="MYIQNLELTSYRNYDHAELQFENKVNVIIGENAQGKTNLMEAIY VLSMAKSHRTSNDKELIRWDKDYAKIEGRVMKQNGAIPMQLVISKKGKKGKVNHIEQQ KLSQYVGALNTIMFAPEDLNLVKGSPQVRRRFLDMEIGQVSPVYLHDLSLYQKILSQR NHFLKQLQTRKQTDRTMLDVLTDQLVEVAAKVVVKRLQFTAQLEKWAQPIHAGISRGL EELTLKYHTALDVSDPLDLSKIGDSYQEAFSKLREKEIERGVTLSGPHRDDVLFYVNG RDVQTYGSQGQQRTTALSLKLAEIDLIHEEIGEYPILLLDDVLSELDDYRQSHLLHTI QGRVQTFVTTTSVDGIDHETLRQAGMFRVQNGALVK*" gene 3437..4549 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" misc_feature 3635..3654 /Source="Nicolas_upshift_promotors" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3653 /Source="Nicolas_upshifts" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" CDS 4567..4812 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of extracellular matrix formation" /protein_id="NP_387886.2" /db_xref="EnsemblGenomes-Gn:BSU00050" /db_xref="EnsemblGenomes-Tr:CAB11781" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG10069" /db_xref="UniProtKB/Swiss-Prot:P37525" /translation="MYIHLGDDFVVSTRDIVGIFDFKANMSPIVEEFLKKQKHKVVPS VNGTPKSIVVTVQNIYYSPLSSSTLKKRAQFMFEIDS*" gene 4567..4812 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" CDS 4867..6783 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit B)" /protein_id="NP_387887.1" /db_xref="EnsemblGenomes-Gn:BSU00060" /db_xref="EnsemblGenomes-Tr:CAB11782" /db_xref="GOA:P05652" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR011557" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR034160" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10070" /db_xref="UniProtKB/Swiss-Prot:P05652" /translation="MEQQQNSYDENQIQVLEGLEAVRKRPGMYIGSTNSKGLHHLVWE IVDNSIDEALAGYCTDINIQIEKDNSITVVDNGRGIPVGIHEKMGRPAVEVIMTVLHA GGKFDGSGYKVSGGLHGVGASVVNALSTELDVTVHRDGKIHRQTYKRGVPVTDLEIIG ETDHTGTTTHFVPDPEIFSETTEYDYDLLANRVRELAFLTKGVNITIEDKREGQERKN EYHYEGGIKSYVEYLNRSKEVVHEEPIYIEGEKDGITVEVALQYNDSYTSNIYSFTNN INTYEGGTHEAGFKTGLTRVINDYARKKGLIKENDPNLSGDDVREGLTAIISIKHPDP QFEGQTKTKLGNSEARTITDTLFSTAMETFMLENPDAAKKIVDKGLMAARARMAAKKA RELTRRKSALEISNLPGKLADCSSKDPSISELYIVEGDSAGGSAKQGRDRHFQAILPL RGKILNVEKARLDKILSNNEVRSMITALGTGIGEDFNLEKARYHKVVIMTDADVDGAH IRTLLLTFFYRYMRQIIENGYVYIAQPPLYKVQQGKRVEYAYNDKELEELLKTLPQTP KPGLQRYKGLGEMNATQLWETTMDPSSRTLLQVTLEDAMDADETFEMLMGDKVEPRRN FIEANARYVKNLDI*" gene 4867..6783 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" promotor_-10 complement(6412..6430) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(6414) /Source="Nicolas_upshifts" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(6446..6451) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 6784..6993 /Source="Nicolas_S_feature" /locus_tag="new_6784_6993" /HighExp="Cold, H2O2, G180, Oxctl, G135, G150, Sw, dia15, LBGexp, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S6" CDS 6994..9459 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" /EC_number="5.99.1.3" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901, 27557712" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901, 27557712; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit A)" /protein_id="NP_387888.1" /db_xref="EnsemblGenomes-Gn:BSU00070" /db_xref="EnsemblGenomes-Tr:CAB11783" /db_xref="GOA:P05653" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005743" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="PDB:4DDQ" /db_xref="SubtiList:BG10071" /db_xref="UniProtKB/Swiss-Prot:P05653" /translation="MSEQNTPQVREINISQEMRTSFLDYAMSVIVSRALPDVRDGLKP VHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYM LVDGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVM PSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPELMEVIPGPDF PTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEK IADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINL LALVDGQPKVLTLKQCLEHYLDHQKVVIRRRTAYELRKAEARAHILEGLRVALDHLDA VISLIRNSQTAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVKL IAELKDILANEYKVLEIIREELTEIKERFNDERRTEIVTSGLETIEDEDLIERENIVV TLTHNGYVKRLPASTYRSQKRGGKGVQGMGTNEDDFVEHLISTSTHDTILFFSNKGKV YRAKGYEIPEYGRTAKGIPIINLLEVEKGEWINAIIPVTEFNAELYLFFTTKHGVSKR TSLSQFANIRNNGLIALSLREDDELMGVRLTDGTKQIIIGTKNGLLIRFPETDVREMG RTAAGVKGITLTDDDVVVGMEILEEESHVLIVTEKGYGKRTPAEEYRTQSRGGKGLKT AKITENNGQLVAVKATKGEEDLMIITASGVLIRMDINDISITGRVTQGVRLIRMAEEE HVATVALVEKNEEDENEEEQEEV*" gene 6994..9459 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" promotor_-35 9373..9376 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 9374 /Source="Nicolas_upshifts" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 9393..9410 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 9440 /Source="Nicolas_upshifts" /id="D2" /incds=0 /nref=251 /ntot=261 /MaxReadThrough="3.73971" /MaxDrop="8.1288" /score="33.5021066" /energy="-14.1" /TU="NA" /idTUdmin="U4" /TUdmin=0 /isTUend="TRUE" promotor_-35 9504..9510 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 9524..9543 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 9529..9614 /Source="Nicolas_S_feature" /locus_tag="new_9529_9614" /HighExp="LBGstat, H2O2, Paraq, Oxctl, UNK1, LBGexp, LPhT, MG-0.2, MG 25, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S7" upshifts 9529 /Source="Nicolas_upshifts" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" promotor_-35 9600..9607 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 9616 /Source="Nicolas_upshifts" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 9622..9641 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" rRNA 9810..11364 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 9810..11364 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" tRNA 11464..11540 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 11464..11540 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" tRNA 11552..11627 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 11552..11627 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" rRNA 11709..14636 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 11709..14636 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" rRNA 14692..14810 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 14692..14810 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" S_feature 14811..15868 /Source="Nicolas_S_feature" /locus_tag="new_14811_15868" /HighExp="G180, T0.0H, T0.30H, G135, T-0.40H, LBGstat, Cold, Paraq, C30, Oxctl" /AntisenseName="yaaC" /AntisenseCor="-4.5985764709218099E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S8" CDS complement(14847..15794) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387889.1" /db_xref="EnsemblGenomes-Gn:BSU00080" /db_xref="EnsemblGenomes-Tr:CAB11784" /db_xref="InterPro:IPR026988" /db_xref="SubtiList:BG10072" /db_xref="UniProtKB/Swiss-Prot:P37526" /translation="MTYHEWKDLALFYSVESTQKFLEKVYILNGINDAKKNSFKNSER FIYFLKHAESFYKQAAYSPLEIKPILLFYGMAQLIKACLITRDPHYPSHTSVLAHGVT TRKRKKQNYCFSDDEVKIQRNGLCVHFMKHLFGQSDIVDERYTMKKLLMAIPELSDIF YFQQKERFMTKVEKDKNEIFVPEEVVINYKMSDSRFAEYMSHHYQWSFTKKNEHGLLF EISPQDKEPWTSTSLLFDMEKNQYYIPSQREQFLRLPEMTIHYLILYNVGMIARYETE WWYELLTQHISDDYVLIQQFLLVSEKKFPKYASQFLLHF*" gene complement(14847..15794) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" promotor_-35 15847..15854 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 15869..15888 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 15870 /Source="Nicolas_upshifts" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" upshifts complement(15875) /Source="Nicolas_upshifts" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" promotor_-10 complement(15884..15895) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(15909..15915) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 15915..17381 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" /EC_number="1.1.1.205" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1722815, 17611193, 1979163, 3125411, 8917437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1722815, 17611193, 1979163, 3125411, 8917437; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inosine-monophosphate dehydrogenase" /protein_id="NP_387890.1" /db_xref="EnsemblGenomes-Gn:BSU00090" /db_xref="EnsemblGenomes-Tr:CAB11785" /db_xref="GOA:P21879" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005990" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG10073" /db_xref="UniProtKB/Swiss-Prot:P21879" /translation="MWESKFSKEGLTFDDVLLVPAKSEVLPRDVDLSVELTKTLKLNI PVISAGMDTVTESAMAIAMARQGGLGIIHKNMSIEQQAEQVDKVKRSERGVITNPFFL TPDHQVFDAEHLMGKYRISGVPIVNNEEDQKLVGIITNRDLRFISDYSMKISDVMTKE ELVTASVGTTLDEAEKILQKHKIEKLPLVDDQNKLKGLITIKDIEKVIEFPNSSKDIH GRLIVGAAVGVTGDTMTRVKKLVEANVDVIVIDTAHGHSQGVLNTVTKIRETYPELNI IAGNVATAEATRALIEAGADVVKVGIGPGSICTTRVVAGVGVPQITAIYDCATEARKH GKTIIADGGIKFSGDITKALAAGGHAVMLGSLLAGTSESPGETEIYQGRRFKVYRGMG SVAAMEKGSKDRYFQEENKKFVPEGIEGRTPYKGPVEETVYQLVGGLRSGMGYCGSKD LRALREEAQFIRMTGAGLRESHPHDVQITKESPNYTIS*" gene 15915..17381 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" downshifts complement(15919) /Source="Nicolas_upshifts" /id="D3" /incds=0 /nref=33 /ntot=102 /MaxReadThrough="1.81989" /MaxDrop="4.44626" /score="-6.76739893" /energy="-12.2" /TU="NA" /idTUdmin="U12" /TUdmin=0 /isTUend="TRUE" promotor_no_box complement(15945..16045) /Source="Nicolas_upshift_promotors" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(15985) /Source="Nicolas_upshifts" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(17238..17833) /Source="Nicolas_S_feature" /locus_tag="new_17238_17833_c" /HighExp="Etha, Gly, C30, Salt, S8, S6, HiTm, S7, Sw, C90" /AntisenseName="dacA" /AntisenseCor="-0.39306815699287101" /AntisenseRegPval="-10.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S9" downshifts 17369 /Source="Nicolas_upshifts" /id="D4" /incds=0 /nref=243 /ntot=277 /MaxReadThrough="3.34899" /MaxDrop="7.78161" /score="26.7620012" /energy="-10.6" /TU="NA" /idTUdmin="U10" /TUdmin="-14" /isTUend="TRUE" promotor_-35 17427..17431 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 17447..17466 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 17453..17533 /Source="Nicolas_S_feature" /locus_tag="new_17453_17533" /HighExp="C30, LBGstat, G180, G150, LBGexp, G135, Lbexp, Oxctl, dia0, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S10" upshifts 17453 /Source="Nicolas_upshifts" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" CDS 17534..18865 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" /EC_number="3.4.16.4" /experiment="publication(s) with functional evidences, PMID:8370539, 9864321, 10383963, 21378199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8370539, 9864321, 10383963, 21378199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5)" /protein_id="NP_387891.1" /db_xref="EnsemblGenomes-Gn:BSU00100" /db_xref="EnsemblGenomes-Tr:CAB11786" /db_xref="GOA:P08750" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10074" /db_xref="UniProtKB/Swiss-Prot:P08750" /translation="MNIKKCKQLLMSLVVLTLAVTCLAPMSKAKAASDPIDINASAAI MIEASSGKILYSKNADKRLPIASMTKMMTEYLLLEAIDQGKVKWDQTYTPDDYVYEIS QDNSLSNVPLRKDGKYTVKELYQATAIYSANAAAIAIAEIVAGSETKFVEKMNAKAKE LGLTDYKFVNATGLENKDLHGHQPEGTSVNEESEVSAKDMAVLADHLITDYPEILETS SIAKTKFREGTDDEMDMPNWNFMLKGLVSEYKKATVDGLKTGSTDSAGSCFTGTAERN GMRVITVVLNAKGNLHTGRFDETKKMFDYAFDNFSMKEIYAEGDQVKGHKTISVDKGK EKEVGIVTNKAFSLPVKNGEEKNYKAKVTLNKDNLTAPVKKGTKVGKLTAEYTGDEKD YGFLNSDLAGVDLVTKENVEKANWFVLTMRSIGGFFAGIWGSIVDTVTGWF*" gene 17534..18865 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" promotor_-10 complement(17822..17840) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(17833) /Source="Nicolas_upshifts" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" promotor_-35 complement(17855..17861) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 18747 /Source="Nicolas_upshifts" /id="D5" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="6.76335" /MaxDrop="2.1925" /score="26.7620012" /energy="-10.6" /TU="U13" /idTUdmin="U10" /TUdmin=1364 /isTUend="FALSE" S_feature 18866..18974 /Source="Nicolas_S_feature" /locus_tag="new_18866_18974" /HighExp="C30, MG 15, MG 10, MG-0.1, MG 25, BMM, ferm, Cold, MG 60, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S11" promotor_-35 18944..18947 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 18962..18981 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 18976..19061 /Source="Nicolas_S_feature" /locus_tag="new_18976_19061" /HighExp="BMM, MG 25, SMM, MG 15, UNK1, MG 10, GM 150, MG-0.1, MG 150, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S12" upshifts 18976 /Source="Nicolas_upshifts" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" CDS 19062..19946 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" /EC_number="4.3.3.6" /EC_number="4.-.-.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14762015, 15771487, 15911615, 16157873, 17144654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762015, 15771487, 15911615, 16157873, 17144654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, synthase subunit" /protein_id="NP_387892.1" /db_xref="EnsemblGenomes-Gn:BSU00110" /db_xref="EnsemblGenomes-Tr:CAB11787" /db_xref="GOA:P37527" /db_xref="InterPro:IPR001852" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033755" /db_xref="PDB:2NV1" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10075" /db_xref="UniProtKB/Swiss-Prot:P37527" /translation="MAQTGTERVKRGMAEMQKGGVIMDVINAEQAKIAEEAGAVAVMA LERVPADIRAAGGVARMADPTIVEEVMNAVSIPVMAKARIGHIVEARVLEAMGVDYID ESEVLTPADEEFHLNKNEYTVPFVCGCRDLGEATRRIAEGASMLRTKGEPGTGNIVEA VRHMRKVNAQVRKVVAMSEDELMTEAKNLGAPYELLLQIKKDGKLPVVNFAAGGVATP ADAALMMQLGADGVFVGSGIFKSDNPAKFAKAIVEATTHFTDYKLIAELSKELGTAMK GIEISNLLPEQRMQERGW*" gene 19062..19946 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" S_feature complement(19194..19923) /Source="Nicolas_S_feature" /locus_tag="new_19194_19923_c" /HighExp="S6, S8, S7, S5, S4, C30, S3, BT, C90, Gly" /AntisenseName="pdxS" /AntisenseCor="-0.65390240445415004" /AntisenseRegPval="-33.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S13" promotor_-10 complement(19911..19929) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(19923) /Source="Nicolas_upshifts" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" promotor_-35 complement(19945..19950) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-35" CDS 19968..20558 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" /EC_number="3.5.1.2" /EC_number="4.3.3.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 14762015, 15771487, 17144654, 18271580, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 14762015, 15771487, 17144654, 18271580, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, glutamine amidotransferase subunit PdxT" /protein_id="NP_387893.1" /db_xref="EnsemblGenomes-Gn:BSU00120" /db_xref="EnsemblGenomes-Tr:CAB11788" /db_xref="GOA:P37528" /db_xref="InterPro:IPR002161" /db_xref="InterPro:IPR021196" /db_xref="InterPro:IPR029062" /db_xref="PDB:1R9G" /db_xref="PDB:2NV0" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10076" /db_xref="UniProtKB/Swiss-Prot:P37528" /translation="MLTIGVLGLQGAVREHIHAIEACGAAGLVVKRPEQLNEVDGLIL PGGESTTMRRLIDTYQFMEPLREFAAQGKPMFGTCAGLIILAKEIAGSDNPHLGLLNV VVERNSFGRQVDSFEADLTIKGLDEPFTGVFIRAPHILEAGENVEVLSEHNGRIVAAK QGQFLGCSFHPELTEDHRVTQLFVEMVEEYKQKALV*" gene 19968..20558 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" misc_RNA 20611..20823 /gene="tboS" /locus_tag="BSU_misc_RNA_1" /product="T-box riboswitch specific of serine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" gene 20611..20823 /gene="tboS" /locus_tag="BSU_misc_RNA_1" downshifts 20788 /Source="Nicolas_upshifts" /id="D6" /incds=0 /nref=9 /ntot=80 /MaxReadThrough="7.14793" /MaxDrop="4.37654" /score="41.1243331" /energy="-23.3" /TU="U13,U15" /idTUdmin="U13" /TUdmin="-1347" /isTUend="FALSE" CDS 20880..22157 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" /EC_number="6.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10546897, 12682299, 14732487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10546897, 12682299, 14732487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="seryl-tRNA synthetase" /protein_id="NP_387894.1" /db_xref="EnsemblGenomes-Gn:BSU00130" /db_xref="EnsemblGenomes-Tr:CAB11789" /db_xref="GOA:P37464" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002317" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR015866" /db_xref="InterPro:IPR033729" /db_xref="SubtiList:BG10077" /db_xref="UniProtKB/Swiss-Prot:P37464" /translation="MLDTKMLRANFQEIKAKLVHKGEDLTDFDKFEALDDRRRELIGK VEELKGKRNEVSQQVAVLKREKKDADHIIKEMREVGEEIKKLDEELRTVEAELDTILL SIPNIPHESVPVGETEDDNVEVRKWGEKPSFAYEPKPHWDIADELGILDFERAAKVTG SRFVFYKGLGARLERALYNFMLDLHVDEYNYTEVIPPYMVNRASMTGTGQLPKFEEDA FKIREEDYFLIPTAEVPITNMHRDEILSGDSLPINYAAFSACFRSEAGSAGRDTRGLI RQHQFNKVELVKFVKPEDSYEELEKLTNQAERVLQLLELPYRVMSMCTGDLGFTAAKK YDIEVWIPSQDTYREISSCSNFEAFQARRANIRFRREAKGKPEHVHTLNGSGLAVGRT VAAILENYQQEDGSVVIPKVLRPYMGNREVMKP*" gene 20880..22157 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" downshifts 22135 /Source="Nicolas_upshifts" /id="D7" /incds=0 /nref=234 /ntot=255 /MaxReadThrough="0.83411" /MaxDrop="7.38039" /score="17.6549558" /energy="-13.3" /TU="NA" /idTUdmin="U13" /TUdmin=0 /isTUend="TRUE" promotor_-35 22246..22253 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 22268..22287 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 22268 /Source="Nicolas_upshifts" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" tRNA 22292..22384 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(UGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 22292..22384 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" downshifts 22407 /Source="Nicolas_upshifts" /id="D8" /incds=0 /nref=168 /ntot=196 /MaxReadThrough="5.02201" /MaxDrop="8.36635" /score="29.7083093" /energy="-12.4" /TU="U17" /idTUdmin="U13" /TUdmin=272 /isTUend="FALSE" S_feature 22452..22529 /Source="Nicolas_S_feature" /locus_tag="new_22452_22529" /HighExp="Cold, H2O2, G180, Paraq, Oxctl, C30, G150, G135, BMM, Heat" /AntisenseName="dck" /AntisenseCor="0.61769771609764101" /AntisenseRegPval="-29" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S14" CDS complement(22496..23149) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" /EC_number="2.7.1.76" /EC_number="2.7.1.74" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6251049, 11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6251049, 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyadenosine/deoxycytidine kinase" /protein_id="NP_387895.1" /db_xref="EnsemblGenomes-Gn:BSU00140" /db_xref="EnsemblGenomes-Tr:CAB11790" /db_xref="GOA:P37529" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10078" /db_xref="UniProtKB/Swiss-Prot:P37529" /translation="MKEHHIPKNSIITVAGTVGVGKSTLTKTLAKRLGFKTSLEEVDH NPYLEKFYHDFERWSFHLQIYFLAERFKEQKTIFEAGGGFVQDRSIYEDTGIFAKMHA DKGTMSKVDYKTYTSLFEAMVMTPYFPHPDVLIYLEGDLENILNRIEQRGREMELQTS RSYWEEMHTRYENWISGFNACPVLKLRIEDYDLLNDENSIENIVDQIASVIHDNQKK* " gene complement(22496..23149) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" promotor_-35 22515..22521 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(22520) /Source="Nicolas_upshifts" /id="D9" /incds=0 /nref=88 /ntot=213 /MaxReadThrough="1.96668" /MaxDrop="4.49235" /score="14.5948578" /energy="-11" /TU="NA" /idTUdmin="U19" /TUdmin="-1" /isTUend="TRUE" S_feature 22531..23167 /Source="Nicolas_S_feature" /locus_tag="new_22531_23167" /HighExp="G180, G135, Cold, C30, Paraq, H2O2, Oxctl, G150, S5, S6" /AntisenseName="dck" /AntisenseCor="0.15155468296621499" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S15" upshifts 22531 /Source="Nicolas_upshifts" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 22535..22546 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(23146..23769) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" /EC_number="2.7.1.113" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyguanosine kinase" /protein_id="NP_387896.1" /db_xref="EnsemblGenomes-Gn:BSU00150" /db_xref="EnsemblGenomes-Tr:CAB11791" /db_xref="GOA:P37530" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10079" /db_xref="UniProtKB/Swiss-Prot:P37530" /translation="MNTAPFIAIEGPIGAGKTTLATMLSQKFGFPMINEIVEDNPYLD KFYDNIKEWSFQLEMFFLCHRYKQLEDTSDHFLKKGQPVIADYHIYKNVIFAERTLSP HQLEKYKKIYHLLTDDLPKPNFIIYIKASLPTLLHRIEKRGRPFEKKIETSYLEQLIS DYEVAIKQLQEADPELTVLTVDGDSKDFVLNKSDFERIAAHVKELIV*" gene complement(23146..23769) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" promotor_-10 complement(23810..23829) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(23828) /Source="Nicolas_upshifts" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" promotor_-35 complement(23845..23849) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(23868..25151) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" /EC_number="3.2.1.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11011148, 11737650, 12177332, 10419957, 18456807, 18835992, 19933362, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore peptidoglycan N-acetylglucosaminidase" /protein_id="NP_387897.1" /db_xref="EnsemblGenomes-Gn:BSU00160" /db_xref="EnsemblGenomes-Tr:CAB11792" /db_xref="GOA:P37531" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10080" /db_xref="UniProtKB/Swiss-Prot:P37531" /translation="MVKQGDTLSAIASQYRTTTNDITETNEIPNPDSLVVGQTIVIPI AGQFYDVKRGDTLTSIARQFNTTAAELARVNRIQLNTVLQIGFRLYIPPAPKRDIESN AYLEPRGNQVSENLQQAAREASPYLTYLGAFSFQAQRNGTLVAPPLTNLRSITESQNT TLMMIITNLENQAFSDELGRILLNDETVKRRLLNEIVENARRYGFRDIHFDFEYLRPQ DREAYNQFLREARDLFHREGLEISTALAPKTSATQQGRWYEAHDYRAHGEIVDFVVLM TYEWGYSGGPPQAVSPIGPVRDVIEYALTEMPANKIVMGQNLYGYDWTLPYTAGGTPA RAVSPQQAIVIADQNNASIQYDQTAQAPFFRYTDAENRRHEVWFEDARSIQAKFNLIK ELNLRGISYWKLGLSFPQNWLLLSDQFNVVKKTFR*" gene complement(23868..25151) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" downshifts complement(23905) /Source="Nicolas_upshifts" /id="D10" /incds=0 /nref=40 /ntot=61 /MaxReadThrough="1.17442" /MaxDrop="6.30997" /score="3.66560192" /energy="-8.4" /TU="NA" /idTUdmin="U20" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(25182..25200) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(25203) /Source="Nicolas_upshifts" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" promotor_-35 complement(25216..25221) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(25221..25766) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2521622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidase (isochorismatase family)" /protein_id="NP_387898.1" /db_xref="EnsemblGenomes-Gn:BSU00170" /db_xref="EnsemblGenomes-Tr:CAB11793" /db_xref="GOA:P37532" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG10081" /db_xref="UniProtKB/Swiss-Prot:P37532" /translation="MSKADKALLIVDMINNFEFDMGETLAKKTEKIVPHILSLKEHAR QNEWPIIYINDHYGLWQADIKNIQQECTNERSKDIITKIAPVDADYFLIKPKHSAFYE TALHTLLTELQVRHIIITGIAGNICVLFTANDAYMREYSITIPKDCIASNSDEDNEFA LTMMENVLFAEITTEEQIIEK*" gene complement(25221..25766) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" promotor_-35 25632..25636 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 25651..25670 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" S_feature 25655..25851 /Source="Nicolas_S_feature" /locus_tag="new_25655_25851" /HighExp="Diami, dia5, H2O2, dia15, T0.30H, T-0.40H, HiOs, T-1.10H, Salt, T0.0H" /AntisenseName="yaaI" /AntisenseCor="9.6546810160837798E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S16" upshifts 25657 /Source="Nicolas_upshifts" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" promotor_-10 complement(25791..25809) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(25810) /Source="Nicolas_upshifts" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" promotor_-35 complement(25824..25830) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 25852..26337 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" /EC_number="3.5.4.33" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15677468, 16014871, 16415880, 16700551, 23658230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA specific adenosine A34 deaminase" /protein_id="NP_387899.1" /db_xref="EnsemblGenomes-Gn:BSU00180" /db_xref="EnsemblGenomes-Tr:CAB11794" /db_xref="GOA:P21335" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR028883" /db_xref="SubtiList:BG10082" /db_xref="UniProtKB/Swiss-Prot:P21335" /translation="MTQDELYMKEAIKEAKKAEEKGEVPIGAVLVINGEIIARAHNLR ETEQRSIAHAEMLVIDEACKALGTWRLEGATLYVTLEPCPMCAGAVVLSRVEKVVFGA FDPKGGCSGTLMNLLQEERFNHQAEVVSGVLEEECGGMLSAFFRELRKKKKAARKNLS E*" gene 25852..26337 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" promotor_-35 26341..26347 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 26361..26380 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" misc_RNA 26379..26732 /gene="scr" /locus_tag="BSU_misc_RNA_2" /product="small cytoplasmic RNA (scRNA, 4.5S RNA), signal recognition particle-like (SRP) component" /experiment="publication(s) with functional evidences, PMID:1372600, 1689715" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1372600, 1689715" gene 26379..26732 /gene="scr" /locus_tag="BSU_misc_RNA_2" S_feature 26383..26532 /Source="Nicolas_S_feature" /locus_tag="new_26383_26532" /HighExp="T1.0H, T5.0H, T1.30H, T3.30H, T3.0H, T2.30H, T4.0H, S8, T-1.10H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S17" upshifts 26383 /Source="Nicolas_upshifts" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" S_feature 26636..26731 /Source="Nicolas_S_feature" /locus_tag="new_26636_26731" /HighExp="S8, Sw, B60, B36, T2.30H, T3.30H, T1.0H, BC, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S18" downshifts 26688 /Source="Nicolas_upshifts" /id="D11" /incds=0 /nref=273 /ntot=278 /MaxReadThrough="4.46774" /MaxDrop="8.31255" /score="23.257527" /energy="-10.3" /TU="U21,U23" /idTUdmin="U21" /TUdmin="-89" /isTUend="FALSE" promotor_-35 26752..26755 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 26770..26789 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 26779 /Source="Nicolas_upshifts" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" CDS 26814..28505 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III subunit tau subunit" /protein_id="NP_387900.2" /db_xref="EnsemblGenomes-Gn:BSU00190" /db_xref="EnsemblGenomes-Tr:CAB11795" /db_xref="GOA:P09122" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR012763" /db_xref="InterPro:IPR022754" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10083" /db_xref="UniProtKB/Swiss-Prot:P09122" /translation="MSYQALYRVFRPQRFEDVVGQEHITKTLQNALLQKKFSHAYLFS GPRGTGKTSAAKIFAKAVNCEHAPVDEPCNECAACKGITNGSISDVIEIDAASNNGVD EIRDIRDKVKFAPSAVTYKVYIIDEVHMLSIGAFNALLKTLEEPPEHCIFILATTEPH KIPLTIISRCQRFDFKRITSQAIVGRMNKIVDAEQLQVEEGSLEIIASAADGGMRDAL SLLDQAISFSGDILKVEDALLITGAVSQLYIGKLAKSLHDKNVSDALETLNELLQQGK DPAKLIEDMIFYFRDMLLYKTAPGLEGVLEKVKVDETFRELSEQIPAQALYEMIDILN KSHQEMKWTNHPRIFFEVAVVKICQTSHQSAADLPEVDMLMKKIQQLEQEVERLKTTG IKAAAESPKKEAPRVPKGGKSNYKAPVGRIHEILKEATRPDLDLLRNSWGKLLAHLKQ QNKVSHAALLNDSEPVAAGSAAFVLKFKYEIHCKMVAEDNNGVRTNLEQILESMLGKR MDLIGVPEAQWGKIREEFLEDHQQENEGSNEPAEEDPLIAEAKKLVGADLIEIKD*" gene 26814..28505 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" promotor_-35 28346..28353 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 28368..28387 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 28383 /Source="Nicolas_upshifts" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" CDS 28529..28852 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16740939, 19208644, 19594923, 20639362, 22333191, 22544270; Product type f : factor" /codon_start=1 /transl_table=11 /product="nucleoid associated protein" /protein_id="NP_387901.1" /db_xref="EnsemblGenomes-Gn:BSU00200" /db_xref="EnsemblGenomes-Tr:CAB11796" /db_xref="GOA:P24281" /db_xref="InterPro:IPR004401" /db_xref="InterPro:IPR036894" /db_xref="SubtiList:BG10084" /db_xref="UniProtKB/Swiss-Prot:P24281" /translation="MRGGMGNMQKMMKQMQKMQKDMAKAQEELAEKVVEGTAGGGMVT VKANGQKEILDVIIKEEVVDPEDIDMLQDLVLAATNEALKKVDEITNETMGQFTKGMN MPGLF*" gene 28529..28852 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" CDS 28867..29463 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12065426, 24285298, 24891441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065426, 24285298, 24891441; Product type f: factor" /codon_start=1 /transl_table=11 /product="recA filament-DNA complex stabilisation factor" /protein_id="NP_387902.1" /db_xref="EnsemblGenomes-Gn:BSU00210" /db_xref="EnsemblGenomes-Tr:CAB11797" /db_xref="GOA:P24277" /db_xref="InterPro:IPR000093" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR015967" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR023627" /db_xref="InterPro:IPR023628" /db_xref="InterPro:IPR034137" /db_xref="SubtiList:BG10085" /db_xref="UniProtKB/Swiss-Prot:P24277" /translation="MQYPEPISKLIDSFMKLPGIGPKTAVRLAFFVLGMKEDVVLDFA KALVNAKRNLTYCSVCGHITDQDPCYICEDTRRDKSVICVVQDPKDVIAMEKMKEYNG QYHVLHGAISPMDGIGPEDIKIPELLKRLQDDQVTEVILATNPNIEGEATAMYISRLL KPSGIKLSRIAHGLPVGGDLEYADEVTLSKALEGRREL*" gene 28867..29463 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" CDS 29481..29705 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387903.1" /db_xref="EnsemblGenomes-Gn:BSU00220" /db_xref="EnsemblGenomes-Tr:CAB11798" /db_xref="InterPro:IPR019644" /db_xref="SubtiList:BG10086" /db_xref="UniProtKB/Swiss-Prot:P37533" /translation="MGFLRKKTLRREFDEKLTEQLFKQKEEWNRQKKLVEKSLEPSAE VLYELKVAEAKYFFYLREAKQRNLKISRWK*" gene 29481..29705 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" promotor_-35 29708..29713 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-35" upshifts 29725 /Source="Nicolas_upshifts" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" promotor_-10 29729..29747 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-10" CDS 29772..30035 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15087499, 17557826" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15087499, 17557826; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the pro-sigma(K) processing machinery" /protein_id="NP_387904.2" /db_xref="EnsemblGenomes-Gn:BSU00230" /db_xref="EnsemblGenomes-Tr:CAB11799" /db_xref="GOA:P24282" /db_xref="InterPro:IPR010001" /db_xref="SubtiList:BG10087" /db_xref="UniProtKB/Swiss-Prot:P24282" /translation="MEPIFIIGIILGLVILLFLSGSAAKPLKWIGITAVKFVAGALLL VCVNMFGGSLGIHVPINLVTTAISGILGIPGIAALVVIKQFII*" gene 29772..30035 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" promotor_-35 30048..30055 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 30069..30088 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 30076..30278 /Source="Nicolas_S_feature" /locus_tag="new_30076_30278" /HighExp="LBGstat, Diami, C30, H2O2, Oxctl, HPh, BMM, GM 120, Paraq, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.899, 0.99" /label="S19" upshifts 30076 /Source="Nicolas_upshifts" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" rRNA 30279..31832 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 30279..31832 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" tRNA 31932..32008 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ile(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 31932..32008 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" tRNA 32020..32095 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 32020..32095 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" rRNA 32177..35103 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 32177..35103 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" S_feature 35104..35236 /Source="Nicolas_S_feature" /locus_tag="new_35104_35236" /HighExp="LBGstat, G135, Oxctl, C30, HPh, Paraq, G180, LPh, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S20" rRNA 35237..35355 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 35237..35355 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" S_feature 35356..35458 /Source="Nicolas_S_feature" /locus_tag="new_35356_35458" /HighExp="Oxctl, Paraq, H2O2, LBGstat, C30, G180, Cold, G135, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S21" promotor_-35 35419..35427 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-35" promotor_-10 35441..35460 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-10" upshifts 35460 /Source="Nicolas_upshifts" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" CDS 35531..35725 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8759874, 15044948, 21935351, 26929302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759874, 15044948, 21935351, 26929302; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="forespore-specific anti-sigma factor" /protein_id="NP_387905.1" /db_xref="EnsemblGenomes-Gn:BSU00240" /db_xref="EnsemblGenomes-Tr:CAB11800" /db_xref="GOA:P37534" /db_xref="InterPro:IPR019700" /db_xref="SubtiList:BG10088" /db_xref="UniProtKB/Swiss-Prot:P37534" /translation="MDETVKLNHTCVICDQEKNRGIHLYTKFICLDCERKVISTSTSD PDYAFYVKKLKSIHTPPLYS*" gene 35531..35725 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" downshifts 35709 /Source="Nicolas_upshifts" /id="D12" /incds=0 /nref=79 /ntot=215 /MaxReadThrough="5.37774" /MaxDrop="4.42494" /score="22.3916007" /energy="-6.7" /TU="U28" /idTUdmin="U27" /TUdmin=3938 /isTUend="FALSE" promotor_-35 35770..35779 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 35791..35806 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 35797 /Source="Nicolas_upshifts" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" CDS 35845..36459 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23155385; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatase" /protein_id="NP_387906.1" /db_xref="EnsemblGenomes-Gn:BSU00250" /db_xref="EnsemblGenomes-Tr:CAB11801" /db_xref="GOA:P37467" /db_xref="InterPro:IPR018770" /db_xref="SubtiList:BG10089" /db_xref="UniProtKB/Swiss-Prot:P37467" /translation="MQRFFHFLVWSLTSSATFVFIGILSFFGLNQSIFLSIVYGLASG AAVYIAGIWNARRLFLKKHELTGREYAYIKKNLEEARQKMVRLRKALFQAKSIQMFKQ NAEMLRIVRRIYLLTKKEPKRFYQAERFFYQTLDSVVELTEKYAFLSSHPKKSKELSM SLSETRITLTELTKRLEEDLTQAMGDEIDELQFELDAAKHSLKK*" gene 35845..36459 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" CDS 36478..37638 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12533473, 20713661" /codon_start=1 /transl_table=11 /product="putative toxic compound resistance protein" /protein_id="NP_387907.1" /db_xref="EnsemblGenomes-Gn:BSU00260" /db_xref="EnsemblGenomes-Tr:CAB11802" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG10090" /db_xref="UniProtKB/Swiss-Prot:P37535" /translation="MNRDQSDLHIDELLADPFGGNIEIPGSEAVKAEKEQVRLVDVLP EENKEKAIQLAGQIDHKNMQSIVLYGSQAQSKLLNFSHDMINHVQKKDVGEIGEILGE LMKKLEQVNPDDLQSKKKGFLARMFGRVSSSLQEVLSKYQKTSVQIDRISLKLEHSKN ALISDNKLLEQLYEKNKEYFAALNVYIAAGELKLEELKTKTIPELKQQAESSDHNQMA VQEVNDLIQFADRLDKRVHDLLLSRQITIQSAPQIRLIQNTNQALAEKIQSSIVTAIP LWKNQVAIALTLLRQRNAVDAQQKVSDTTNELLLKNAELLKTNTIETARANERGLVDI DTLKKVQESLISTLEETLTIQEEGRIKRRQAEEELMMMEGDLKQKLITIKER*" gene 36478..37638 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" S_feature 37639..37719 /Source="Nicolas_S_feature" /locus_tag="new_37639_37719" /HighExp="T0.0H, T-0.40H, T0.30H, T-1.10H, T-1.40H, Salt, T1.0H, G150, Diami, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="0.984, 0.715" /TUlongSig="NA" /TUlongPSig="NA" /label="S22" CDS 37720..39162 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9723923, 20876533, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative decarboxylase" /protein_id="NP_387908.1" /db_xref="EnsemblGenomes-Gn:BSU00270" /db_xref="EnsemblGenomes-Tr:CAB11803" /db_xref="GOA:P37536" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10091" /db_xref="UniProtKB/Swiss-Prot:P37536" /translation="MNTPLYKALIQHARRNSHSFHVPGHHNGDVFFDDAKSIFDPLLT IDVTELAGLDDLHHPSGVIKEAQELASQLYGSAESFFLVNGTTVGNLAMILSVCEPGD TILVQRNCHKSVFHAVDLSGAEPVYLAPDVDSAMHVPTHVPLGTIKEALEAYPDAKGL VLTNPTYYGHSADLTEIITEAHHYGIPVLVDEAHGAHFILGEPFPVSALKMGADIVVQ SAHKTLPAMTMGSYLHLNSSCRINRDRVAEYLNRLQSSSPSYPIMASLDIARAYVQHI IEEQKLSDILQRIETLKQTFDSLTNAEAVNPANPLIITDPLKLTIRSKRGHSGYTLQS ILERANIFTELADENQVLLVLPLGGKRRINAEIIRSIDEEIEKTPPDQTFVSAEWGVQ PVTVLPYPKKVLHSFKKEYVSFEEAAGRLNAEDIIPYPPGIPMIMAGERITKESVQKL SRLISMKTHVQGNMKIKEKQLLVYIEEEKS*" gene 37720..39162 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" promotor_-35 39082..39088 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-35" promotor_-10 39103..39121 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-10" upshifts 39112 /Source="Nicolas_upshifts" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" CDS 39159..39797 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" /EC_number="2.7.4.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696781, 12682299, 18523102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696781, 12682299, 18523102; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate kinase" /protein_id="NP_387909.2" /db_xref="EnsemblGenomes-Gn:BSU00280" /db_xref="EnsemblGenomes-Tr:CAB11804" /db_xref="GOA:P37537" /db_xref="InterPro:IPR018094" /db_xref="InterPro:IPR018095" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10092" /db_xref="UniProtKB/Swiss-Prot:P37537" /translation="MSGLFITFEGPEGAGKTTVLQEIKNILTAEGLQVMATREPGGID IAEQIREVILNENNILMDPKTEALLYAAARRQHLVEKVKPALEQGFIVLCDRFIDSSL AYQGYARGLGIDEVLSINEFAIGDMMPHVTVYFSIDPEEGLKRIYANGSREKNRLDLE KLDFHTKVQEGYQELMKRFPERFHSVDAGQSKDLVVQDVLKVIDEALKKIQL*" gene 39159..39797 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" promotor_-35 39792..39799 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 39812..39831 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 39823 /Source="Nicolas_upshifts" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" CDS 39871..40200 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" /experiment="publication(s) with functional evidences, PMID:10913081, 25433025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 25433025; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal transduction receptor, cyclic di-AMP binding" /protein_id="NP_387910.1" /db_xref="EnsemblGenomes-Gn:BSU00290" /db_xref="EnsemblGenomes-Tr:CAB11805" /db_xref="InterPro:IPR010375" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="PDB:4RLE" /db_xref="SubtiList:BG10093" /db_xref="UniProtKB/Swiss-Prot:P37538" /translation="MKLIVAVVQDQDSNRLLKTLTDHNFRVTKLATTGGFLKSGNTTF MIGVEDIRVNKALSLIKENGQKRDQMIAPVSPMGGNADSYVPYPVEVEVGGATVFVLP VDEFHQF*" gene 39871..40200 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" CDS 40213..40653 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387911.1" /db_xref="EnsemblGenomes-Gn:BSU00300" /db_xref="EnsemblGenomes-Tr:CAB11806" /db_xref="InterPro:IPR005585" /db_xref="InterPro:IPR024042" /db_xref="SubtiList:BG10094" /db_xref="UniProtKB/Swiss-Prot:P37539" /translation="MKINKDIRTFIDNKQIPSVKTSEITASFKTSMENQSSKMKLDQL TRLLSDIEAFGKRLTKSRNFKDLARFKGLVKRFVKEAVDSGLSHETSKSFDLYGNSRT LGLVKEIDDKLIQLTEEMMDQEKPAIDLLERIGEIKGLLINLYT*" gene 40213..40653 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" CDS 40665..41654 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8509334, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8509334, 12060778, 12682299, 22333191, 23525462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III clamp loader delta' subunit" /protein_id="NP_387912.1" /db_xref="EnsemblGenomes-Gn:BSU00310" /db_xref="EnsemblGenomes-Tr:CAB11807" /db_xref="GOA:P37540" /db_xref="InterPro:IPR004622" /db_xref="InterPro:IPR015199" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10095" /db_xref="UniProtKB/Swiss-Prot:P37540" /translation="MAISWKEMNELQPRVMKLLYNSIEKDRLSHAYLFEGKKGTGKLD AALLLAKSFFCLEGGAEPCESCRNCKRIESGNHPDLHLVQPDGLSIKKAQIQALQEEF SKTGLESHKKLYIISHADQMTANAANSLLKFLEEPNKDTMAVLITEQPQRLLDTIISR CQTLPFQPLQPKAIEDRLIEQDVSPHMARLLANMTNNVAEAVELSRNDEFAESRAKVI KLYEVLHQRKGHAFFFIQDQWMPFFKEKTHQEMGLDMLLLIYRDVLSIQIGNEDKLIY QDLFQSIKQHALQSTQQSVTNQILAVLEAKKRLHSNVNVQGLMEHLVLMLQEG*" gene 40665..41654 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" CDS 41657..42484 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12270811, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12270811, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex of RNaseY (RicAFT complex /FAD / two [4Fe-4S]2+)" /protein_id="NP_387913.1" /db_xref="EnsemblGenomes-Gn:BSU00320" /db_xref="EnsemblGenomes-Tr:CAB11808" /db_xref="GOA:P37541" /db_xref="InterPro:IPR007557" /db_xref="SubtiList:BG10096" /db_xref="UniProtKB/Swiss-Prot:P37541" /translation="MYNVIGVRFKKAGKIYYFDPNGFHIEHDSCVIVETVRGVEYGQV VIANKQVDEHDVVLPLRKVIRVADDRDLLIVEENKQEALSAFDICQKKVIEHGLDMKL VDVEFTFDRNKVIFYFTADGRVDFRELVKDLASIFKTRIELRQIGVRDEAKMLGGIGP CGRMLCCSTFLGDFEPVSIKMAKDQNLSLNPTKISGLCGRLMCCLKYENDEYETAKEQ LPDIGEMITTANGPAKVVGLNILERVLQVELINREKVIEYTWEELLEEGVVSAQTTD* " gene 41657..42484 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" CDS 42499..42858 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15927750, 16461910, 19737352, 21895792, 23909787, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15927750, 16461910, 19737352, 21895792, 23909787, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="subunit of the DNA replication complex" /protein_id="NP_387914.1" /db_xref="EnsemblGenomes-Gn:BSU00330" /db_xref="EnsemblGenomes-Tr:CAB11809" /db_xref="GOA:P37542" /db_xref="InterPro:IPR010377" /db_xref="PDB:5DOL" /db_xref="SubtiList:BG10097" /db_xref="UniProtKB/Swiss-Prot:P37542" /translation="MDKKELFDTVINLEEQIGSLYRQLGDLKQHIGEMIEENHHLQLE NKHLRKRLDDTTQQIEKFKADKKESKTQKTEQTDIGEGYDNLARLYQEGFHICNVHYG SVRKEDCLFCLSFLNKK*" gene 42499..42858 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" CDS 42917..43660 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" /EC_number="2.1.1.223" /function="10.3: tRNA and rRNA base modification" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22905870, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA1(Val) (adenine(37)-N6)-methyltransferase" /protein_id="NP_387915.1" /db_xref="EnsemblGenomes-Gn:BSU00340" /db_xref="EnsemblGenomes-Tr:CAB11810" /db_xref="GOA:P37543" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10098" /db_xref="UniProtKB/Swiss-Prot:P37543" /translation="MVSLHDDERLDYLLAEDMKIIQSPTVFAFSLDAVLLSKFAYVPI QKGKIVDLCTGNGIVPLLLSTRSKADILGVEIQERLHDMAVRSVEYNKLDDQIQIIHD DLKNMPEKLGHNRYDVVTCNPPYFKTPKQTEQNMNEHLRIARHEIHCTLEDVISVSSK LLKQGGKAALVHRPGRLLEIFELMKAYQIEPKRVQFVYPKQGKEANTILVEGIKGGRP DLKILPPLFVYDEQNEYTKEIRTILYGDK*" gene 42917..43660 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" CDS 43647..43946 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11483577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UvrC-Intron-type (URI) endonuclease" /protein_id="NP_387916.1" /db_xref="EnsemblGenomes-Gn:BSU00350" /db_xref="EnsemblGenomes-Tr:CAB11811" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG12700" /db_xref="UniProtKB/Swiss-Prot:O31414" /translation="METNNHFFYVVKCKDNSWYAGYTNDLHKRVKTHNDGKGAKYTKV RRPVELIFAESFSTKREAMQAEYYFKKLTRKKKELYIEEKRNSKEAVYVKAPNEL*" gene 43647..43946 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" CDS 43921..44799 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" /EC_number="2.1.1.198" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 19965768, 25893373; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA 2'-O-ribose C1402 methyltransferase" /protein_id="NP_387917.1" /db_xref="EnsemblGenomes-Gn:BSU00360" /db_xref="EnsemblGenomes-Tr:CAB11812" /db_xref="GOA:P37544" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR008189" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR018063" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10099" /db_xref="UniProtKB/Swiss-Prot:P37544" /translation="MLRRQMSFNGKSDMGILYLVPTPIGNLEDMTFRAIDTLKSVDAI AAEDTRQTKKLCHVYEIETPLVSYHEHNKESSGHKIIEWLKSGKNIALVSDAGLPTIS DPGAEIVKDFTDIGGYVVPLPGANAALTALIASGIVPQPFFFYGFLNRQKKEKKKELE ALKKRQETIIFYEAPHRLKETLSAMAEILGDREIAVTRELTKKYEEFIRGTISEVIGW ANEDQIRGEFCLVVEGSNNEEVDEEEQWWETLTAKEHVEHYISKGATSKEAIKKAAVD RNVPKREVYDAYHIKQ*" gene 43921..44799 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" downshifts 44772 /Source="Nicolas_upshifts" /id="D13" /incds=0 /nref=23 /ntot=177 /MaxReadThrough="3.33195" /MaxDrop="3.72723" /score="5.97354542" /energy="-10.2" /TU="U29,U31" /idTUdmin="U29" /TUdmin="-23" /isTUend="FALSE" CDS complement(44848..45138) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for transition state genes (AbrB-SurF)" /protein_id="NP_387918.1" /db_xref="EnsemblGenomes-Gn:BSU00370" /db_xref="EnsemblGenomes-Tr:CAB11813" /db_xref="GOA:P08874" /db_xref="InterPro:IPR007159" /db_xref="PDB:1YFB" /db_xref="PDB:1YSF" /db_xref="PDB:1Z0R" /db_xref="PDB:2K1N" /db_xref="PDB:2MJG" /db_xref="PDB:2RO4" /db_xref="SubtiList:BG10100" /db_xref="UniProtKB/Swiss-Prot:P08874" /translation="MFMKSTGIVRKVDELGRVVIPIELRRTLGIAEKDALEIYVDDEK IILKKYKPNMTCQVTGEVSDDNLKLAGGKLVLSKEGAEQIISEIQNQLQNLK*" gene complement(44848..45138) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" downshifts complement(44850) /Source="Nicolas_upshifts" /id="D14" /incds=0 /nref=216 /ntot=263 /MaxReadThrough="2.17237" /MaxDrop="7.75729" /score="20.9582436" /energy="-10.2" /TU="U32" /idTUdmin="U32" /TUdmin="-23" /isTUend="FALSE" downshifts 45169 /Source="Nicolas_upshifts" /id="D15" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="2.53543" /MaxDrop="4.31699" /score="13.7153159" /energy="-14.4" /TU="NA" /idTUdmin="U29" /TUdmin=374 /isTUend="FALSE" promotor_-10 complement(45205..45224) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(45222) /Source="Nicolas_upshifts" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" S_feature complement(45224..45399) /Source="Nicolas_S_feature" /locus_tag="new_45224_45399_c" /HighExp="C30, H2O2, G180, Etha, S0, GM 25, Gly, G135, MG 25, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S23" promotor_-35 complement(45238..45245) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(45395..45414) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-10" upshifts complement(45399) /Source="Nicolas_upshifts" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" promotor_-35 complement(45428..45435) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-35" promotor_-35 45499..45503 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-35" promotor_-10 45518..45537 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-10" S_feature 45524..45632 /Source="Nicolas_S_feature" /locus_tag="new_45524_45632" /HighExp="LBGtran, Heat, dia5, dia15, LBGexp, Lbexp, dia0, H2O2, Diami, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S24" upshifts 45524 /Source="Nicolas_upshifts" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" CDS 45633..47627 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" /EC_number="6.1.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11233169, 12682299, 12792655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA synthetase" /protein_id="NP_387919.1" /db_xref="EnsemblGenomes-Gn:BSU00380" /db_xref="EnsemblGenomes-Tr:CAB11814" /db_xref="GOA:P37465" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004495" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014758" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR023457" /db_xref="InterPro:IPR033911" /db_xref="SubtiList:BG10101" /db_xref="UniProtKB/Swiss-Prot:P37465" /translation="MPQENNTFYITTPIYYPSGKLHIGHAYTTVAGDAMARYKRLKGF DVRYLTGTDEHGQKIQQKAEQENITPQEYVDRAAADIQKLWKQLEISNDDFIRTTEKR HKVVIEKVFQKLLDNGDIYLDEYEGWYSIPDETFYTETQLVDIERNEKGEVIGGKSPD SGHPVELIKEESYFFRMGKYADRLLKYYEENPTFIQPESRKNEMINNFIKPGLEDLAV SRTTFDWGVKVPENPKHVVYVWIDALFNYLTALGYDTENDELYQKYWPADVHLVGKEI VRFHTIYWPIMLMALDLPLPKQVFAHGWLLMKDGKMSKSKGNVVDPVTLIERYGLDEL RYYLLREVPFGSDGVFTPEGFVERINYDLANDLGNLLNRTVAMINKYFDGQIGSYKGA VTEFDHTLTSVAEETVKAYEKAMENMEFSVALSTLWQLISRTNKYIDETAPWVLAKDP AKEEELRSVMYHLAESLRISAVLLQPFLTKTPEKMFEQLGITDESLKAWDSITAFGQL KDTKVQKGEPLFPRLEAEEEIAYIKGKMQGSAPAKEETKEEEPQEVDRLPEITIDQFM DVELRVAEVIEAEPVKKADRLLKLQLDLGFEKRQVVSGIAKHYTPEELVGKKLVCVTN LKPVKLRGELSQGMILAGEADGVLKVVSIDQSLPKGTRIK*" gene 45633..47627 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" promotor_-10 complement(46381..46400) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(46389) /Source="Nicolas_upshifts" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(46416..46420) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 47611 /Source="Nicolas_upshifts" /id="D16" /incds=0 /nref=18 /ntot=206 /MaxReadThrough="4.8491" /MaxDrop="2.9167" /score="13.7153159" /energy="-14.4" /TU="U34" /idTUdmin="U34" /TUdmin="-2288" /isTUend="FALSE" S_feature complement(47673..50019) /Source="Nicolas_S_feature" /locus_tag="new_47673_50019_c" /HighExp="T0.30H, T1.0H, T1.30H, Salt, C30, T2.0H, T-0.40H, T0.0H, T2.30H, T-1.10H" /AntisenseName="yabE" /AntisenseCor="-0.28154713646185298" /AntisenseRegPval="-5.6" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S25" CDS 47706..48473 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10747959, 16014871, 16461678, 19332551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acyl-tRNA deacylase" /protein_id="NP_387920.1" /db_xref="EnsemblGenomes-Gn:BSU00390" /db_xref="EnsemblGenomes-Tr:CAB11815" /db_xref="GOA:P37545" /db_xref="InterPro:IPR001130" /db_xref="InterPro:IPR015991" /db_xref="InterPro:IPR018228" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10102" /db_xref="UniProtKB/Swiss-Prot:P37545" /translation="MLFDTHAHLNAEQYDTDLEEVIERAKAEKVERIVVVGFDRPTIT RAMEMIEEYDFIYAAIGWHPVDAIDMTEEDLAWIKELSAHEKVVAIGEMGLDYHWDKS PKDIQKEVFRNQIALAKEVNLPIIIHNRDATEDVVTILKEEGAEAVGGIMHCFTGSAE VARECMKMNFYLSFGGPVTFKNAKKPKEVVKEIPNDRLLIETDCPFLTPHPFRGKRNE PSYVKYVAEQIAELKEMTFEEIASITTENAKRLFRIN*" gene 47706..48473 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" S_feature 48474..48554 /Source="Nicolas_S_feature" /locus_tag="new_48474_48554" /HighExp="Heat, C30, LBGtran, LBGstat, C90, Etha, M40t45, LPhT, MG 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S26" promotor_-35 48531..48536 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 48552..48570 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 48556 /Source="Nicolas_upshifts" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" promotor_-35 48581..48584 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-35" promotor_-10 48599..48618 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-10" upshifts 48616 /Source="Nicolas_upshifts" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" CDS 48629..49942 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15774001, 19047346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall shaping enzyme" /protein_id="NP_387921.1" /db_xref="EnsemblGenomes-Gn:BSU00400" /db_xref="EnsemblGenomes-Tr:CAB11816" /db_xref="GOA:P37546" /db_xref="InterPro:IPR007137" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR011098" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG10103" /db_xref="UniProtKB/Swiss-Prot:P37546" /translation="MGEREGRVDSLLDTLYNLSEEKEAFFITQKMKKLFSVKLSKSKV ILVAACLLLAGSGTAYAAHELTKQSVSVSINGKKKHIRTHANTVGDLLETLDIKTRDE DKITPAKQTKITADMDVVYEAAKPVKLTINGEEKTLWSTAKTVGALLDEQDVDVKEQD QIDPAIDTDISKDMKINIEPAFQVTVNDAGKQKKIWTTSTTVADFLKQQKMNIKDEDK IKPALDAKLTKGKADITITRIEKVTDVVEEKIAFDVKKQEDASLEKGKEKVVQKGKEG KLKKHFEVVKENGKEVSRELVKEETAEQSKDKVIAVGTKQSSPKFETVSASGDSKTVV SRSNESTGKVMTVSSTAYTASCSGCSGHTATGVNLKNNPNAKVIAVDPNVIPLGSKVH VEGYGYAIAADTGSAIKGNKIDVFFPEKSSAYRWGNKTVKIKILN*" gene 48629..49942 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" promotor_-35 48649..48656 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 48667 /Source="Nicolas_upshifts" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" promotor_-10 48671..48690 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 49903 /Source="Nicolas_upshifts" /id="D17" /incds=0 /nref=87 /ntot=220 /MaxReadThrough="5.02755" /MaxDrop="4.87493" /score="27.529638" /energy="-11.3" /TU="U36,U37,U38" /idTUdmin="U34" /TUdmin=4 /isTUend="TRUE" promotor_-35 49965..49969 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 49985..50004 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 49987..50086 /Source="Nicolas_S_feature" /locus_tag="new_49987_50086" /HighExp="LoTm, H2O2, G180, G135, G150, Paraq, Oxctl, C30, dia15, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.843, 0.943" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S27" upshifts 49987 /Source="Nicolas_upshifts" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" promotor_-10 complement(50011..50026) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(50027) /Source="Nicolas_upshifts" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" promotor_-35 complement(50038..50047) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 50083..50099 /Source="Nicolas_upshift_promotors" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 50087..50647 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" /EC_number="3.1.26.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11233981, 11976317, 12794188, 16077031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11233981, 11976317, 12794188, 16077031; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease M5" /protein_id="NP_387922.1" /db_xref="EnsemblGenomes-Gn:BSU00410" /db_xref="EnsemblGenomes-Tr:CAB11817" /db_xref="GOA:P37547" /db_xref="InterPro:IPR004466" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR025156" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG10104" /db_xref="UniProtKB/Swiss-Prot:P37547" /translation="MKIKEIIVVEGRDDTARIKLAVDADTIETNGSAIDDHVIDQIRL AQKTRGVIILTDPDFPGEKIRKTISEAVPGCKHAFLPKHLAKPKNKRGIGVEHASVES IRACLENVHEEMEAQPSDISAEDLIHAGLIGGPAAKCRRERLGDLLKIGYTNGKQLQK RLQMFQIKKSDFMSALDTVMREEQNE*" gene 50087..50647 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" upshifts 50097 /Source="Nicolas_upshifts" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" CDS 50640..51518 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 99430, 6801425, 11327780, 1690648, 22391551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dimethyladenosine 16S ribosomal RNA transferase" /protein_id="NP_387923.1" /db_xref="EnsemblGenomes-Gn:BSU00420" /db_xref="EnsemblGenomes-Tr:CAB11818" /db_xref="GOA:P37468" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR011530" /db_xref="InterPro:IPR020596" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023165" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10105" /db_xref="UniProtKB/Swiss-Prot:P37468" /translation="MNKDIATPIRTKEILKKYGFSFKKSLGQNFLIDTNILNRIVDHA EVTEKTGVIEIGPGIGALTEQLAKRAKKVVAFEIDQRLLPILKDTLSPYENVTVIHQD VLKADVKSVIEEQFQDCDEIMVVANLPYYVTTPIIMKLLEEHLPLKGIVVMLQKEVAE RMAADPSSKEYGSLSIAVQFYTEAKTVMIVPKTVFVPQPNVDSAVIRLILRDGPAVDV ENESFFFQLIKASFAQRRKTLLNNLVNNLPEGKAQKSTIEQVLEETNIDGKRRGESLS IEEFAALSNGLYKALF*" gene 50640..51518 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" downshifts 51483 /Source="Nicolas_upshifts" /id="D18" /incds=0 /nref=152 /ntot=229 /MaxReadThrough="3.0815" /MaxDrop="4.58632" /score="20.4155562" /energy="-9.4" /TU="NA" /idTUdmin="U36" /TUdmin=0 /isTUend="TRUE" promotor_-35 51533..51542 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 51556..51575 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 51558..51679 /Source="Nicolas_S_feature" /locus_tag="new_51558_51679" /HighExp="S7, S6, S8, BT, S5, B36, G/S, Pyr, B60, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S28" upshifts 51558 /Source="Nicolas_upshifts" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" CDS 51680..52552 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 11040425, 16751597, 19060142, 19833771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 11040425, 16751597, 19060142, 19833771; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protease" /protein_id="NP_387924.1" /db_xref="EnsemblGenomes-Gn:BSU00430" /db_xref="EnsemblGenomes-Tr:CAB11819" /db_xref="GOA:P37548" /db_xref="InterPro:IPR008764" /db_xref="SubtiList:BG10106" /db_xref="UniProtKB/Swiss-Prot:P37548" /translation="MQFQIGDMVARKSYQMDVLFRIIGIEQTSKGNSIAILHGDEVRL IADSDFSDLVAVKKDEQMMRKKKDESRMNESLELLRQDYKLLREKQEYYATSQYQHQE HYFHMPGKVLHLDGDEAYLKKCLNVYKKIGVPVYGIHCHEKKMSASIEVLLDKYRPDI LVITGHDAYSKQKGGIDDLNAYRHSKHFVETVQTARKKIPHLDQLVIFAGACQSHFES LIRAGANFASSPSRVNIHALDPVYIVAKISFTPFMERINVWEVLRNTLTREKGLGGIE TRGVLRIGMPYKSN*" gene 51680..52552 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" downshifts 52539 /Source="Nicolas_upshifts" /id="D19" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.30424" /MaxDrop="7.1507" /score="26.6672651" /energy="-11.5" /TU="NA" /idTUdmin="U42" /TUdmin=0 /isTUend="TRUE" S_feature 52649..52719 /Source="Nicolas_S_feature" /locus_tag="new_52649_52719" /HighExp="S8, S5, S7, S6, S4, BT, LoTm, G/S, nit, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S29" promotor_-35 52710..52717 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 52721 /Source="Nicolas_upshifts" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" promotor_-10 52731..52750 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(52740..52754) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(52747) /Source="Nicolas_upshifts" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(52763..52767) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 52763..53023 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12761295, 22720735, 23378512; Producttype ph: phenotype" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387925.1" /db_xref="EnsemblGenomes-Gn:BSU00440" /db_xref="EnsemblGenomes-Tr:CAB11820" /db_xref="GOA:P37466" /db_xref="InterPro:IPR009366" /db_xref="SubtiList:BG10107" /db_xref="UniProtKB/Swiss-Prot:P37466" /translation="MAKTLSDIKRSLDGNLGKRLTLKANGGRRKTIERSGILAETYPS VFVIQLDQDENSFERVSYSYADILTETVELTFNDDAASSVAF*" gene 52763..53023 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" downshifts 52935 /Source="Nicolas_upshifts" /id="D20" /incds=1 /nref=4 /ntot=158 /MaxReadThrough="8.09861" /MaxDrop="2.7867" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U42" /TUdmin=396 /isTUend="FALSE" downshifts 53022 /Source="Nicolas_upshifts" /id="D21" /incds=0 /nref=191 /ntot=264 /MaxReadThrough="5.88511" /MaxDrop="6.03144" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U43" /TUdmin="-331" /isTUend="FALSE" promotor_-35 53088..53094 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 53108..53119 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 53111..53182 /Source="Nicolas_S_feature" /locus_tag="new_53111_53182" /HighExp="S8, Cold, S6, S7, ferm, S5, nit, Etha, G135, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S30" upshifts 53111 /Source="Nicolas_upshifts" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" CDS 53183..53368 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7959056, 8982008, 11092849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7959056, 8982008, 11092849; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_387926.1" /db_xref="EnsemblGenomes-Gn:BSU00450" /db_xref="EnsemblGenomes-Tr:CAB11821" /db_xref="GOA:P37549" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10108" /db_xref="UniProtKB/Swiss-Prot:P37549" /translation="MGRRRGVMSDEFKYELAKDLGFYDTVKNGGWGEIRARDAGNMVK RAIEIAEQQMAQNQNNR*" gene 53183..53368 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" downshifts 53353 /Source="Nicolas_upshifts" /id="D22" /incds=0 /nref=54 /ntot=153 /MaxReadThrough="2.67408" /MaxDrop="6.21058" /score="38.1065567" /energy="-12.6" /TU="NA" /idTUdmin="U43" /TUdmin=0 /isTUend="TRUE" S_feature complement(53363..55717) /Source="Nicolas_S_feature" /locus_tag="new_53363_55717_c" /HighExp="S5, S4, S6, T5.0H, S3, S8, S7, T4.0H, T3.30H, C30" /AntisenseName="ispE" /AntisenseCor="-0.66604185700913698" /AntisenseRegPval="-35.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S31" promotor_-35 53446..53450 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-35" promotor_-10 53466..53485 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-10" upshifts 53469 /Source="Nicolas_upshifts" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" CDS 53516..54385 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" /EC_number="2.7.1.148" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11361082, 12682299, 12771135, 17458547, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase" /protein_id="NP_387927.1" /db_xref="EnsemblGenomes-Gn:BSU00460" /db_xref="EnsemblGenomes-Tr:CAB11822" /db_xref="GOA:P37550" /db_xref="InterPro:IPR004424" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10109" /db_xref="UniProtKB/Swiss-Prot:P37550" /translation="MRILEKAPAKINLSLDVTRKRPDGYHEVEMIMTTIDLADRIELT ELAEDEVRVSSHNRFVPDDQRNLAYQAAKLIKDRYNVKKGVSIMITKVIPVAAGLAGG SSDAAATLRGLNRLWNLNLSAETLAELGAEIGSDVSFCVYGGTALATGRGEKIKHIST PPHCWVILAKPTIGVSTAEVYRALKLDGIEHPDVQGMIEAIEEKSFQKMCSRLGNVLE SVTLDMHPEVAMIKNQMKRFGADAVLMSGSGPTVFGLVQYESKVQRIYNGLRGFCDQV YAVRMIGEQNALD*" gene 53516..54385 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" CDS 54441..55298 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11591660, 12837783, 12837784, 15629952, 16163456, 27329548" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12837783, 12837784, 15629952, 16163456, 27329548; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine biosynthesis operon (PurR-pRpp)" /protein_id="NP_387928.1" /db_xref="EnsemblGenomes-Gn:BSU00470" /db_xref="EnsemblGenomes-Tr:CAB11823" /db_xref="GOA:P37551" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010078" /db_xref="InterPro:IPR015265" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1O57" /db_xref="PDB:1P4A" /db_xref="SubtiList:BG10110" /db_xref="UniProtKB/Swiss-Prot:P37551" /translation="MKFRRSGRLVDLTNYLLTHPHELIPLTFFSERYESAKSSISEDL TIIKQTFEQQGIGTLLTVPGAAGGVKYIPKMKQAEAEEFVQTLGQSLANPERILPGGY VYLTDILGKPSVLSKVGKLFASVFAEREIDVVMTVATKGIPLAYAAASYLNVPVVIVR KDNKVTEGSTVSINYVSGSSNRIQTMSLAKRSMKTGSNVLIIDDFMKAGGTINGMINL LDEFNANVAGIGVLVEAEGVDERLVDEYMSLLTLSTINMKEKSIEIQNGNFLRFFKDN LLKNGETES*" gene 54441..55298 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" CDS 55295..55672 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" /EC_number="3.5.99.10" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2113912, 12515541, 14729707, 10557275, 10919400, 10368157, 20562306, 23815688; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminoacrylate/iminopropionate hydrolase/deaminase" /protein_id="NP_387929.1" /db_xref="EnsemblGenomes-Gn:BSU00480" /db_xref="EnsemblGenomes-Tr:CAB11824" /db_xref="GOA:P37552" /db_xref="InterPro:IPR006056" /db_xref="InterPro:IPR006175" /db_xref="InterPro:IPR019897" /db_xref="InterPro:IPR035959" /db_xref="PDB:1QD9" /db_xref="SubtiList:BG10111" /db_xref="UniProtKB/Swiss-Prot:P37552" /translation="MTKAVHTKHAPAAIGPYSQGIIVNNMFYSSGQIPLTPSGEMVNG DIKEQTHQVFSNLKAVLEEAGASFETVVKATVFIADMEQFAEVNEVYGQYFDTHKPAR SCVEVARLPKDALVEIEVIALVK*" gene 55295..55672 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" downshifts 55662 /Source="Nicolas_upshifts" /id="D23" /incds=0 /nref=172 /ntot=226 /MaxReadThrough="3.8891" /MaxDrop="4.63425" /score="22.9159767" /energy="-12.3" /TU="U46" /idTUdmin="U46" /TUdmin="-155" /isTUend="FALSE" promotor_-10 complement(55706..55724) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 55707..55815 /Source="Nicolas_S_feature" /locus_tag="new_55707_55815" /HighExp="S8, S7, Etha, B36, LoTm, C30, Sw, B60, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S32" upshifts complement(55718) /Source="Nicolas_upshifts" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" promotor_-35 complement(55740..55745) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 55795..55803 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-35" promotor_-10 55814..55832 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-10" upshifts 55817 /Source="Nicolas_upshifts" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" CDS 55866..56159 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733708, 10348850, 10648512, 16428420, 27048798" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733708, 10348850, 10648512, 16428420, 27048798; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for spore cortex synthesis (stage V sporulation)" /protein_id="NP_387930.1" /db_xref="EnsemblGenomes-Gn:BSU00490" /db_xref="EnsemblGenomes-Tr:CAB11825" /db_xref="GOA:P28015" /db_xref="InterPro:IPR007170" /db_xref="InterPro:IPR036751" /db_xref="PDB:2IA9" /db_xref="SubtiList:BG10112" /db_xref="UniProtKB/Swiss-Prot:P28015" /translation="MEVTDVRLRRVNTDGRMRAIASITLDHEFVVHDIRVIDGNNGLF VAMPSKRTPDGEFRDITHPINSSTRGKIQDAVLNEYHRLGDTEALEFEEAGAS*" gene 55866..56159 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" downshifts 56148 /Source="Nicolas_upshifts" /id="D24" /incds=0 /nref=263 /ntot=285 /MaxReadThrough="5.11673" /MaxDrop="7.2673" /score="19.392304" /energy="-22.3" /TU="U48" /idTUdmin="U46" /TUdmin=331 /isTUend="FALSE" S_feature 56193..56304 /Source="Nicolas_S_feature" /locus_tag="new_56193_56304" /HighExp="B60, B36, M9-stat, S2, BT, LoTm, Etha, Lbstat, T0.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S33" promotor_-35 56286..56290 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 56306..56325 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 56306 /Source="Nicolas_upshifts" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" CDS 56352..57722 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" /EC_number="2.3.1.157" /EC_number="2.7.7.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional glucosamine-1-phosphate N-acetyltransferase/UDP-N-acetylglucosamine pyrophosphorylase" /protein_id="NP_387931.1" /db_xref="EnsemblGenomes-Gn:BSU00500" /db_xref="EnsemblGenomes-Tr:CAB11826" /db_xref="GOA:P14192" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005882" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10113" /db_xref="UniProtKB/Swiss-Prot:P14192" /translation="MDKRFAVVLAAGQGTRMKSKLYKVLHPVCGKPMVEHVVDEALKL SLSKLVTIVGHGAEEVKKQLGDKSEYALQAKQLGTAHAVKQAQPFLADEKGVTIVICG DTPLLTAETMEQMLKEHTQREAKATILTAVAEDPTGYGRIIRSENGAVQKIVEHKDAS EEERLVTEINTGTYCFDNEALFRAIDQVSNDNAQGEYYLPDVIEILKNEGETVAAYQT GNFQETLGVNDRVALSQAEQFMKERINKRHMQNGVTLIDPMNTYISPDAVIGSDTVIY PGTVIKGEVQIGEDTIIGPHTEIMNSAIGSRTVIKQSVVNHSKVGNDVNIGPFAHIRP DSVIGNEVKIGNFVEIKKTQFGDRSKASHLSYVGDAEVGTDVNLGCGSITVNYDGKNK YLTKIEDGAFIGCNSNLVAPVTVGEGAYVAAGSTVTEDVPGKALAIARARQVNKDDYV KNIHKK*" gene 56352..57722 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" downshifts complement(57697) /Source="Nicolas_upshifts" /id="D25" /incds=0 /nref=5 /ntot=84 /MaxReadThrough="2.39379" /MaxDrop="3.65636" /score="-7.65702938" /energy="-13.8" /TU="NA" /idTUdmin="U47" /TUdmin="-4312" /isTUend="FALSE" CDS 57745..58698 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" /EC_number="2.7.6.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2169413, 3038693, 8522540, 22083279, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2169413, 3038693, 8522540, 22083279, 25890046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylpyrophosphate synthetase" /protein_id="NP_387932.1" /db_xref="EnsemblGenomes-Gn:BSU00510" /db_xref="EnsemblGenomes-Tr:CAB11827" /db_xref="GOA:P14193" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR000842" /db_xref="InterPro:IPR005946" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR029099" /db_xref="PDB:1DKR" /db_xref="PDB:1DKU" /db_xref="PDB:1IBS" /db_xref="SubtiList:BG10114" /db_xref="UniProtKB/Swiss-Prot:P14193" /translation="MSNQYGDKNLKIFSLNSNPELAKEIADIVGVQLGKCSVTRFSDG EVQINIEESIRGCDCYIIQSTSDPVNEHIMELLIMVDALKRASAKTINIVIPYYGYAR QDRKARSREPITAKLFANLLETAGATRVIALDLHAPQIQGFFDIPIDHLMGVPILGEY FEGKNLEDIVIVSPDHGGVTRARKLADRLKAPIAIIDKRRPRPNVAEVMNIVGNIEGK TAILIDDIIDTAGTITLAANALVENGAKEVYACCTHPVLSGPAVERINNSTIKELVVT NSIKLPEEKKIERFKQLSVGPLLAEAIIRVHEQQSVSYLFS*" gene 57745..58698 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" promotor_-35 58711..58717 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 58730 /Source="Nicolas_upshifts" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" promotor_-10 58732..58750 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 58783..59397 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8522540, 9669336, 10369900, 12432960, 17198710" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8522540, 9669336, 10369900, 12432960, 17198710; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein BL25 (Ctc), binding 5S RNA" /protein_id="NP_387933.1" /db_xref="EnsemblGenomes-Gn:BSU00520" /db_xref="EnsemblGenomes-Tr:CAB11828" /db_xref="GOA:P14194" /db_xref="InterPro:IPR001021" /db_xref="InterPro:IPR011035" /db_xref="InterPro:IPR020056" /db_xref="InterPro:IPR020057" /db_xref="InterPro:IPR029751" /db_xref="InterPro:IPR037121" /db_xref="SubtiList:BG10115" /db_xref="UniProtKB/Swiss-Prot:P14194" /translation="MATLTAKERTDFTRSSLRNIRTSGHVPGIIYGKDTGNKPVSLDS VELIKTLRDEGKNAVITLEVSGEKHSVMVTDLQTDPLKNEITHADFQVVNMSEDIEVE VPIHLTGEAIGVKNGGVLQQPLYALTVKAKPKAIPQTIEADISSLDVNEVLTIADLPA GGDYSFNHESDEVVASILPPQQQEAAEVDEEESADAQPEGENEQ*" gene 58783..59397 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" downshifts 59381 /Source="Nicolas_upshifts" /id="D26" /incds=0 /nref=120 /ntot=249 /MaxReadThrough="8.65206" /MaxDrop="5.4784" /score="1.94770319" /energy="-11.2" /TU="U49,U50" /idTUdmin="U48" /TUdmin=682 /isTUend="FALSE" CDS 59504..60070 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" /EC_number="3.1.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8635758, 12100553, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8635758, 12100553, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-tRNA hydrolase" /protein_id="NP_387934.1" /db_xref="EnsemblGenomes-Gn:BSU00530" /db_xref="EnsemblGenomes-Tr:CAB11829" /db_xref="GOA:P37470" /db_xref="InterPro:IPR001328" /db_xref="InterPro:IPR018171" /db_xref="InterPro:IPR036416" /db_xref="SubtiList:BG10116" /db_xref="UniProtKB/Swiss-Prot:P37470" /translation="MLVIAGLGNPGKNYENTRHNVGFMVIDQLAKEWNIELNQNKFNG LYGTGFVSGKKVLLVKPLTYMNLSGECLRPLMDYYDVDNEDLTVIYDDLDLPTGKIRL RTKGSAGGHNGIKSLIQHLGTSEFDRIRIGIGRPVNGMKVVDYVLGSFTKEEAPEIEE AVDKSVKACEASLSKPFLEVMNEFNAKV*" gene 59504..60070 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" misc_feature 59683..59686 /Source="Nicolas_upshift_promotors" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 59689 /Source="Nicolas_upshifts" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" CDS 60130..60360 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" /experiment="publication(s) with functional evidences, PMID:21037003, 28598017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21037003, 28598017; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein required for the switch from F to G during sporulation (anti sigma F)" /protein_id="NP_387935.1" /db_xref="EnsemblGenomes-Gn:BSU00540" /db_xref="EnsemblGenomes-Tr:CAB11830" /db_xref="GOA:P37553" /db_xref="InterPro:IPR020115" /db_xref="PDB:5MSL" /db_xref="SubtiList:BG10117" /db_xref="UniProtKB/Swiss-Prot:P37553" /translation="MALHYYCRHCGVKVGSLESSMVSTDSLGFQHLTNEERNDMISYK ENGDVHVLTICEDCQEALDRNPHYHEYHTFIQ*" gene 60130..60360 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" S_feature 60361..60429 /Source="Nicolas_S_feature" /locus_tag="new_60361_60429" /HighExp="Etha, S5, S4, S7, S8, S6, S3, H2O2, Diami, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigB, SigA" /TUshortPSig="0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S34" CDS 60430..63963 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription-repair coupling factor" /protein_id="NP_387936.1" /db_xref="EnsemblGenomes-Gn:BSU00550" /db_xref="EnsemblGenomes-Tr:CAB11831" /db_xref="GOA:P37474" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR004576" /db_xref="InterPro:IPR005118" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG10118" /db_xref="UniProtKB/Swiss-Prot:P37474" /translation="MDNIQTFIKESDDFKSIINGLHEGLKEQLLAGLSGSARSVFTSA LANETNKPIFLITHNLYQAQKVTDDLTSLLEDRSVLLYPVNELISSEIAVASPELRAQ RLDVINRLTNGEAPIVVAPVAAIRRMLPPVEVWKSSQMLIQVGHDIEPDQLASRLVEV GYERSDMVSAPGEFSIRGGIIDIYPLTSENPVRIELFDTEVDSIRSFNSDDQRSIETL TSINIGPAKELIIRPEEKARAMEKIDSGLAASLKKLKADKQKEILHANISHDKERLSE GQTDQELVKYLSYFYEKPASLLDYTPDNTLLILDEVSRIHEMEEQLQKEEAEFITNLL EEGKILHDIRLSFSFQKIVAEQKRPLLYYSLFLRHVHHTSPQNIVNVSGRQMQSFHGQ MNVLAGEMERFKKSNFTVVFLGANKERTQKLSSVLADYDIEAAMTDSKKALVQGQVYI MEGELQSGFELPLMKLAVITEEELFKNRVKKKPRKQKLTNAERIKSYSELQIGDYVVH INHGIGKYLGIETLEINGIHKDYLNIHYQGSDKLYVPVEQIDQVQKYVGSEGKEPKLY KLGGSEWKRVKKKVETSVQDIADDLIKLYAEREASKGYAFSPDHEMQREFESAFPYQE TEDQLRSIHEIKKDMERERPMDRLLCGDVGYGKTEVAIRAAFKAIGDGKQVALLVPTT ILAQQHYETIKERFQDYPINIGLLSRFRTRKEANETIKGLKNGTVDIVIGTHRLLSKD VVYKDLGLLIIDEEQRFGVTHKEKIKQIKANVDVLTLTATPIPRTLHMSMLGVRDLSV IETPPENRFPVQTYVVEYNGALVREAIERELARGGQVYFLYNRVEDIERKADEISMLV PDAKVAYAHGKMTENELETVMLSFLEGESDVLVSTTIIETGVDIPNVNTLIVFDADKM GLSQLYQLRGRVGRSNRVAYAYFTYRRDKVLTEVAEKRLQAIKEFTELGSGFKIAMRD LTIRGAGNLLGAQQHGFIDSVGFDLYSQMLKEAIEERKGDTAKTEQFETEIDVELDAY IPETYIQDGKQKIDMYKRFRSVATIEEKNELQDEMIDRFGNYPKEVEYLFTVAEMKVY ARQERVELIKQDKDAVRLTISEEASAEIDGQKLFELGNQYGRQIGLGMEGKKLKISIQ TKGRSADEWLDTVLGMLKGLKDVKKQTISST*" gene 60430..63963 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" promotor_-35 63981..63987 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 64001..64098 /Source="Nicolas_S_feature" /locus_tag="new_64001_64098" /HighExp="S5, S7, S8, S6, S4, Etha, S3, H2O2, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, Sig-, SigB, SigA" /TUshortPSig="1, 0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S35" promotor_-10 64001..64012 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 64001 /Source="Nicolas_upshifts" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" CDS 64099..64635 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of sporulation / germination" /protein_id="NP_387937.1" /db_xref="EnsemblGenomes-Gn:BSU00560" /db_xref="EnsemblGenomes-Tr:CAB11832" /db_xref="GOA:P37554" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR014213" /db_xref="PDB:2RO5" /db_xref="PDB:2W1R" /db_xref="PDB:2W1T" /db_xref="SubtiList:BG10119" /db_xref="UniProtKB/Swiss-Prot:P37554" /translation="MKATGIVRRIDDLGRVVIPKEIRRTLRIREGDPLEIFVDRDGEV ILKKYSPISELGDFAKEYADALYDSLGHSVLICDRDVYIAVSGSSKKDYLNKSISEML ERTMDQRSSVLESDAKSVQLVNGIDEDMNSYTVGPIVANGDPIGAVVIFSKDQTMGEV EHKAVETAAGFLARQMEQ*" gene 64099..64635 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" downshifts 64639 /Source="Nicolas_upshifts" /id="D27" /incds=0 /nref=236 /ntot=260 /MaxReadThrough="1.92082" /MaxDrop="6.20706" /score="-2.69593259" /energy="-11.6" /TU="NA" /idTUdmin="U49" /TUdmin=0 /isTUend="TRUE" misc_feature 64735..64754 /Source="Nicolas_upshift_promotors" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 64746 /Source="Nicolas_upshifts" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" CDS 64817..66415 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_387938.1" /db_xref="EnsemblGenomes-Gn:BSU00570" /db_xref="EnsemblGenomes-Tr:CAB11833" /db_xref="GOA:P37555" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10120" /db_xref="UniProtKB/Swiss-Prot:P37555" /translation="MDDSIGVKRHWIWQGAFVLILAGVITKILSAVYRVPFQNIVGDV GFYIYQQVYPFLGIAVMLSTSGFPVIISKLMNDYSEKNHHTILKISALFLSLIGILLF LCLYLGAVPIALFMGDSHLAVLIQVAAYAFLLFPFVALLRGGFQGRHEMLPSALSQMT EQFLRVAVLLGLSFWLVKKGASLYTAGAAAASGSLAGSLVALIILGFFWFKTKRDNQT DRQNENVITTKELTKKLLLYSVTICVSSLLLLFIQLVDALNLYALLSGGEASEEAKCL KGIYDRGQPLLQLGSVFAVSIATSLVPYISMAVKNKELKIMKEKITSSLKLCLVLGTG ASAGLICILKPVNIMLFQNGEGTGALQVFSCSILFASLAVTAAAVLQGAGYTVFPAIA VGAGVAVKWVLNTLLVPRYGIEGASLATAASFAAVAGLNLYQLRQKEWLDKLRGVLIP IIGSALLMSAVLLAYTRLWTFLFPATGRGAAVIESLSAVAIGGAVFIYCMMRLGIFTD EELNSVPFGSKLSKFMRRREQNGG*" gene 64817..66415 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" promotor_-35 66286..66293 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-35" promotor_-10 66308..66327 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-10" upshifts 66322 /Source="Nicolas_upshifts" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" CDS 66405..67874 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11178267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fusion methylase and nucleotide pyrophosphohydrolase" /protein_id="NP_387939.1" /db_xref="EnsemblGenomes-Gn:BSU00580" /db_xref="EnsemblGenomes-Tr:CAB11834" /db_xref="GOA:P37556" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011551" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR024180" /db_xref="InterPro:IPR035013" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10121" /db_xref="UniProtKB/Swiss-Prot:P37556" /translation="MAGKITVVGLGAGDMDQLTIGIHKLLTKADTLYVRTKDHPLIEE LEKETKNIRFFDDIYEKHDQFEAVYEEIADILFEAARREDVVYAVPGHPFVAEKTVQL LTERQEKENVQVKVAGGQSFLDATFNVLQIDPIEGFQFVDAGTLSADELELRHHLIIC QVYDQMTASEVKLTLMEKLPDDYEVVIVTAAGSRGEEIRTVPLFELDRNVALNNLTSV YIPPIKEEKLLYHEFSTFRSIIRELRGPNGCPWDKKQTHQSLKQYMIEECYELLEAID EEDTDHMIEELGDVLLQVLLHAQIGEDEGYFTIDDVIKGISEKMVRRHPHVFKDVKVQ DENDVLANWEDIKKAEKNTSESSLLDSVPKTLPALSKAAKLQKKAAKVGFDWEDVSDI WEKVSEEMKEFSSEVSEAPHEHNLKAEFGDILFALVNVARFYKIEPEEALTMTNDKFR RRFSYIEETAKEEGVELADMSLEDMDKLWNEAKETERRS*" gene 66405..67874 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" promotor_-35 67046..67053 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-35" promotor_-10 67067..67085 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-10" upshifts 67081 /Source="Nicolas_upshifts" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" promotor_no_box complement(67469..67569) /Source="Nicolas_upshift_promotors" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(67509) /Source="Nicolas_upshifts" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 67877..68137 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10675343, 10675344, 19013177; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal RNA binding protein involved in 50S recycling; heat shock protein" /protein_id="NP_387940.1" /db_xref="EnsemblGenomes-Gn:BSU00590" /db_xref="EnsemblGenomes-Tr:CAB11835" /db_xref="GOA:P37557" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR025490" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10122" /db_xref="UniProtKB/Swiss-Prot:P37557" /translation="MRLDKFLKVSRLIKRRTLAKEVADQGRISINGNQAKASSDVKPG DELTVRFGQKLVTVQVNELKDTTKKEEAANMYTILKEEKLGE*" gene 67877..68137 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" promotor_-35 68142..68147 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 68163..68181 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 68181 /Source="Nicolas_upshifts" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" downshifts complement(68213) /Source="Nicolas_upshifts" /id="D28" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="1.93659" /MaxDrop="3.17193" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=3014 /isTUend="FALSE" CDS 68216..68518 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15231775, 21904870, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15231775, 21904870, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore protein involved in the shaping of the spore coat" /protein_id="NP_387941.1" /db_xref="EnsemblGenomes-Gn:BSU00600" /db_xref="EnsemblGenomes-Tr:CAB11836" /db_xref="GOA:P37558" /db_xref="InterPro:IPR012504" /db_xref="InterPro:IPR022476" /db_xref="SubtiList:BG10123" /db_xref="UniProtKB/Swiss-Prot:P37558" /translation="MNSYYDQKGSSSVPEQHDVTMKGRKHLDISGVKHVESFDNEEFL LETVMGMLSVRGQNLQMKNLDVEKGIVSIKGRVFDLVYLDEQQGDKAKGFFSKLFK*" gene 68216..68518 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" CDS 68515..69150 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein of the forespore" /protein_id="NP_387942.1" /db_xref="EnsemblGenomes-Gn:BSU00610" /db_xref="EnsemblGenomes-Tr:CAB11837" /db_xref="GOA:P37559" /db_xref="InterPro:IPR014242" /db_xref="InterPro:IPR019074" /db_xref="SubtiList:BG10124" /db_xref="UniProtKB/Swiss-Prot:P37559" /translation="MTLTTQFYTMLAMSGMGLWLGASLDTYRLFVIRAKTARWLLFIH DILFWIMQGLLFFYVLLHVNEGEFRIYIFLAVLLGVATYQSLCKRIYIKILKFVIYLV VSVYQFFKKLIQHVLFRPIVWTCGAIIWLAAFLFKKTYSLIGFLLLCLYKIVMVLCFP IRFIAKQCLKLLPVKMRLTFRRYFEKGAGFLKKKKKLLITIRTTITRFLKR*" gene 68515..69150 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" promotor_-35 69020..69029 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 69042..69057 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 69044 /Source="Nicolas_upshifts" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" promotor_-35 69076..69084 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 69095..69113 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 69105 /Source="Nicolas_upshifts" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" CDS 69168..69545 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_387943.1" /db_xref="EnsemblGenomes-Gn:BSU00620" /db_xref="EnsemblGenomes-Tr:CAB11838" /db_xref="GOA:P37471" /db_xref="InterPro:IPR007060" /db_xref="SubtiList:BG10125" /db_xref="UniProtKB/Swiss-Prot:P37471" /translation="MNFSRERTITEIQNDYKEQVERQNQLKKRRRKGLYRRLTVFGAL VFLTAIVLASSVWSQTSSLSAKEEKKEQLEKELKSLKTKQTDLKEEISKLKDEDYVTE LARRDLFMSGDGEIIFNVEKKSK*" gene 69168..69545 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" CDS 69626..70012 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 15066026, 16014871, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; polyribonucleotide nucleotidyltransferase or phosphorylase" /protein_id="NP_387944.1" /db_xref="EnsemblGenomes-Gn:BSU00630" /db_xref="EnsemblGenomes-Tr:CAB11839" /db_xref="GOA:P37560" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG10126" /db_xref="UniProtKB/Swiss-Prot:P37560" /translation="MSIEVGSKLQGKITGITNFGAFVELPGGSTGLVHISEVADNYVK DINDHLKVGDQVEVKVINVEKDGKIGLSIKKAKDRPQARPRNDFRPKESFEQKMNKFL KDSEDRLSSLKRNTESKRGGRGARRG*" gene 69626..70012 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" downshifts 70006 /Source="Nicolas_upshifts" /id="D29" /incds=0 /nref=247 /ntot=274 /MaxReadThrough="3.67278" /MaxDrop="8.3221" /score="23.2738869" /energy="-12.5" /TU="U58" /idTUdmin="U53" /TUdmin="-1" /isTUend="TRUE" promotor_-35 70120..70127 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 70141..70160 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 70156 /Source="Nicolas_upshifts" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" tRNA 70181..70257 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="methionine transfer RNA (CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 70181..70257 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" tRNA 70267..70338 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="glutamate transfer RNA (UUC); Evidence 2a: Functionfrom experimental evidences in other organisms; Producttype n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 70267..70338 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" downshifts 70337 /Source="Nicolas_upshifts" /id="D30" /incds=0 /nref=2 /ntot=58 /MaxReadThrough="4.83761" /MaxDrop="5.55326" /score="25.2769629" /energy="-10.8" /TU="U58,U60" /idTUdmin="U58" /TUdmin="-198" /isTUend="FALSE" S_feature 70382..70493 /Source="Nicolas_S_feature" /locus_tag="new_70382_70493" /HighExp="Cold, G180, C30, G135, G150, Oxctl, Paraq, H2O2, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S36" misc_feature 70489..70508 /Source="Nicolas_upshift_promotors" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 70495 /Source="Nicolas_upshifts" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" CDS 70538..73021 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" /EC_number="3.1.3.16" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10747015, 12180929, 15126482, 15866939, 15978076, 28358838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10747015, 12180929, 15126482, 15866939, 15978076, 28358838; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="SpoIIAA-phosphate serine phosphatase" /protein_id="NP_387945.1" /db_xref="EnsemblGenomes-Gn:BSU00640" /db_xref="EnsemblGenomes-Tr:CAB11840" /db_xref="GOA:P37475" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014221" /db_xref="InterPro:IPR036457" /db_xref="PDB:3T91" /db_xref="PDB:3T9Q" /db_xref="PDB:5UCG" /db_xref="SubtiList:BG10127" /db_xref="UniProtKB/Swiss-Prot:P37475" /translation="MEKAERRVNGPMAGQALEKLQSFFNRGTKLVTHHLHSLFFYKGF IYVVIGFLLGRAFILSEVLPFALPFFGAMLLIRRDKAFYAVLAVLAGALTISPKHSLL ILAALLAFFVFSKVAAFITDDRVKALPIVVFFSMAAARAGFVYAQNGVFTTYDYVMAI VEAGLSFILTLIFLQSLPIFTVKKVKQSLKIEEIICFMILIASVLTGLAGLSYQGMQA EHILARYVVLSFSFIGGASIGCTVGVVTGLILGLANIGNLYQMSLLAFSGLLGGLLKE GKKAGAAIGLIVGSLLISLYGEGSAGLMTTLYESLIAVCLFLLTPQSITRKVARYIPG TVEHLQEQQQYARKIRDVTAQKVDQFSNVFHALSESFATFYQASDEQTDDSEVDLFLS KITEHSCQTCYKKNRCWVQNFDKTYDLMKQVMLETEEKEYASNRRLKKEFQQYCSKSK QVEELIEDELAHHHAHLTLKKKVQDSRRLVAEQLLGVSEVMADFSREIKREREQHFLQ EEQIIEALQHFGIEIQHVEIYSLEQGNIDIEMTIPFSGHGESEKIIAPMLSDILEEQI LVKAEQHSPHPNGYSHVAFGSTKSYRVSTGAAHAAKGGGLVSGDSYSMMELGARKYAA AISDGMGNGARAHFESNETIKLLEKILESGIDEKIAIKTINSILSLRTTDEIYSTLDL SIIDLQDASCKFLKVGSTPSFIKRGDQVMKVQASNLPIGIINEFDVEVVSEQLKAGDL LIMMSDGIFEGPKHVENHDLWMKRKMKGLKTNDPQEIADLLMEEVIRTRSGQIEDDMT VVVVRIDHNTPKWASIPVPAIFQNKQEIS*" gene 70538..73021 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" downshifts 70579 /Source="Nicolas_upshifts" /id="D31" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="5.5737" /MaxDrop="3.93473" /score="25.2769629" /energy="-10.8" /TU="U60,U61" /idTUdmin="U58" /TUdmin=44 /isTUend="FALSE" S_feature complement(71190..71799) /Source="Nicolas_S_feature" /locus_tag="new_71190_71799_c" /HighExp="S8, S6, S4, S5, S3, S7, M9-stat, T5.0H, LoTm, Pyr" /AntisenseName="spoIIE" /AntisenseCor="0.685558251745638" /AntisenseRegPval="-38" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S37" downshifts complement(71216) /Source="Nicolas_upshifts" /id="D32" /incds=1 /nref=2 /ntot=11 /MaxReadThrough="2.2425" /MaxDrop="4.29972" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=11 /isTUend="TRUE" promotor_-10 complement(71772..71790) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(71798) /Source="Nicolas_upshifts" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" promotor_-35 complement(71806..71811) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 72003..72009 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 72024..72042 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 72031 /Source="Nicolas_upshifts" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" promotor_-35 73041..73044 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 73062..73079 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 73065 /Source="Nicolas_upshifts" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" CDS 73106..73843 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387946.1" /db_xref="EnsemblGenomes-Gn:BSU00650" /db_xref="EnsemblGenomes-Tr:CAB11841" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG10128" /db_xref="UniProtKB/Swiss-Prot:P37561" /translation="MNNGHLNQILLITDGCSNHGEDPLAMAAFAKEQGITVNVIGIME ENQIDPEAMKEVEGIALAGGGVHQVVYASQLSQTVQMVTKKAMTQTLQGVVNQELKQI LGKNVEMEELSPEKRGEVMEVVDELGETVHLQVLVLVDTSASMAPKLPTVKEALIDLS VSLNSRIGNNEFAMCIFPGKKQEVELVLNWTPKLQSLSTLFAKLSTGGITPTGPAIRE ATLQFEKIRSRRGMLADDERRFDEFGM*" gene 73106..73843 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" CDS 73809..74825 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23634894, 24731262, 25278935" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23634894, 24731262, 25278935; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine-protein kinase" /protein_id="NP_387947.2" /db_xref="EnsemblGenomes-Gn:BSU00660" /db_xref="EnsemblGenomes-Tr:CAB11842" /db_xref="GOA:P37562" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG10129" /db_xref="UniProtKB/Swiss-Prot:P37562" /translation="MMNDALTSLACSLKPGTTIKGKWNGNTYTLRKQLGKGANGIVYL AETSDGHVALKVSDDSLSITSEVNVLKSFSKAQSVTMGPSFFDTDDAYIPSANTKVSF YAMEYIKGPLLLKYVSDKGAEWIPVLMIQLLSSLSVLHQQGWIFGDLKPDNLIVTGPP ARIRCIDVGGTTKEGRAIKEYTEFYDRGYWGYGTRKAEPSYDLFAVAMIMINSVHKKE FKKTNQPKEQLRSLIEGNPLLQKYKKALFSALNGDYQSADEMKKDMLDAGQKAAQRKQ PIKASPQPATRQRQQKPRQGKITKTRYTPKQKPAKSGGLFETTLIVISVLALYFAYII FFLI*" gene 73809..74825 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" promotor_-35 74357..74363 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-35" promotor_-10 74379..74397 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-10" upshifts 74385 /Source="Nicolas_upshifts" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" promotor_-35 74855..74862 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 74876..74895 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 74886 /Source="Nicolas_upshifts" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" CDS 74929..76347 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" /EC_number="6.3.4.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14527414, 16039592, 17005971, 22720735, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14527414, 16039592, 17005971, 22720735, 24001521; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(ile2) lysidine synthetase" /protein_id="NP_387948.1" /db_xref="EnsemblGenomes-Gn:BSU00670" /db_xref="EnsemblGenomes-Tr:CAB11843" /db_xref="GOA:P37563" /db_xref="InterPro:IPR011063" /db_xref="InterPro:IPR012094" /db_xref="InterPro:IPR012795" /db_xref="InterPro:IPR012796" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015262" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG10130" /db_xref="UniProtKB/Swiss-Prot:P37563" /translation="MKSVKDFLNKHNLTLKGATIIVGVSGGPDSMALLHALHTLCGRS ANVIAAHVDHRFRGAESEEDMRFVQAYCKAEQLVCETAQINVTAYAQEKGLNKQAAAR DCRYQFFEEIMSKHQADYLALAHHGDDQVETMLMKLAKGTLGTGLAGMQPVRRFGTGR IIRPFLTITKEEILHYCHENGLSYRTDESNAKDDYTRNRFRKTVLPFLKQESPDVHKR FQKVSEALTEDEQFLQSLTKDEMNKVITSQSNTSVEINSSQLLALPMPLQRRGVQLIL NYLYENVPSSFSAHHIQQFLDWAENGGPSGVLDFPKGLKVVKSYQTCLFTFEQWQCKN VPFEYQISGAADETAVLPNGYLIEARHYADSPEEHGNAVFITSEKKVRFPLTIRTRKA GDRIKLKGMNGSKKVKDIFIDKKLPLQERDNWPIVTDASGEIIWIPGLKKSIFEDLVI PNSDRIVLQYRQHEKCRGQAKS*" gene 74929..76347 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" promotor_-35 75724..75731 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 75746..75765 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 75749 /Source="Nicolas_upshifts" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" downshifts complement(76342) /Source="Nicolas_upshifts" /id="D33" /incds=0 /nref=2 /ntot=142 /MaxReadThrough="2.51342" /MaxDrop="2.96272" /score="12.3455896" /energy="-9.1" /TU="NA" /idTUdmin="U68" /TUdmin="-11" /isTUend="TRUE" CDS 76344..76886 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" /EC_number="2.4.2.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3110131, 6408059, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 6408059, 24001521; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hypoxanthine-guanine phosphoribosyltransferase" /protein_id="NP_387949.1" /db_xref="EnsemblGenomes-Gn:BSU00680" /db_xref="EnsemblGenomes-Tr:CAB11844" /db_xref="GOA:P37472" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005904" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10131" /db_xref="UniProtKB/Swiss-Prot:P37472" /translation="MMKHDIEKVLISEEEIQKKVKELGAELTSEYQDTFPLAIGVLKG ALPFMADLIKHIDTYLEMDFMDVSSYGNSTVSSGEVKIIKDLDTSVEGRDILIIEDII DSGLTLSYLVELFRYRKAKSIKIVTLLDKPSGRKADIKADFVGFEVPDAFVVGYGLDY AERYRNLPYIGVLKPAVYES*" gene 76344..76886 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" upshifts complement(76749) /Source="Nicolas_upshifts" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(76751..76755) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(76773..76776) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 76887..76983 /Source="Nicolas_S_feature" /locus_tag="new_76887_76983" /HighExp="Diami, H2O2, dia5, G135, dia15, G150, Paraq, C90, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.999, 1, 0.842" /TUlongSig="SigB, SigA" /TUlongPSig="1, 0.99" /label="S38" CDS 76984..78897 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" /EC_number="3.4.24.-" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent cytoplasmic membrane protease" /protein_id="NP_387950.1" /db_xref="EnsemblGenomes-Gn:BSU00690" /db_xref="EnsemblGenomes-Tr:CAB11845" /db_xref="GOA:P37476" /db_xref="InterPro:IPR000642" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR003960" /db_xref="InterPro:IPR005936" /db_xref="InterPro:IPR011546" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR037219" /db_xref="SubtiList:BG10132" /db_xref="UniProtKB/Swiss-Prot:P37476" /translation="MNRVFRNTIFYLLILLVVIGVVSYFQTSNPKTENMSYSTFIKNL DDGKVDSVSVQPVRGVYEVKGQLKNYDKDQYFLTHVPEGKGADQIFNALKKTDVKVEP AQETSGWVTFLTTIIPFVIIFILFFFLLNQAQGGGSRVMNFGKSKAKLYTEEKKRVKF KDVAGADEEKQELVEVVEFLKDPRKFAELGARIPKGVLLVGPPGTGKTLLAKACAGEA GVPFFSISGSDFVEMFVGVGASRVRDLFENAKKNAPCLIFIDEIDAVGRQRGAGLGGG HDEREQTLNQLLVEMDGFSANEGIIIIAATNRADILDPALLRPGRFDRQITVDRPDVI GREAVLKVHARNKPLDETVNLKSIAMRTPGFSGADLENLLNEAALVAARQNKKKIDAR DIDEATDRVIAGPAKKSRVISKKERNIVAYHEGGHTVIGLVLDEADMVHKVTIVPRGQ AGGYAVMLPREDRYFQTKPELLDKIVGLLGGRVAEEIIFGEVSTGAHNDFQRATNIAR RMVTEFGMSEKLGPLQFGQSQGGQVFLGRDFNNEQNYSDQIAYEIDQEIQRIIKECYE RAKQILTENRDKLELIAQTLLKVETLDAEQIKHLIDHGTLPERNFSDDEKNDDVKVNI LTKTEEKKDDTKE*" gene 76984..78897 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" downshifts 78895 /Source="Nicolas_upshifts" /id="D34" /incds=0 /nref=187 /ntot=269 /MaxReadThrough="5.00908" /MaxDrop="8.91482" /score="38.4132386" /energy="-12.9" /TU="U66,U67" /idTUdmin="U64" /TUdmin=0 /isTUend="TRUE" misc_feature complement(78934..78938) /Source="Nicolas_upshift_promotors" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 78940..79025 /Source="Nicolas_S_feature" /locus_tag="new_78940_79025" /HighExp="H2O2, G180, G135, dia15, Paraq, G150, Oxctl, Diami, Cold, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S39" upshifts complement(78942) /Source="Nicolas_upshifts" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 79002..79009 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 79023..79042 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" S_feature 79027..79091 /Source="Nicolas_S_feature" /locus_tag="new_79027_79091" /HighExp="dia5, H2O2, dia15, Paraq, Diami, G180, LBGexp, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S40" upshifts 79027 /Source="Nicolas_upshifts" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" CDS 79092..79868 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15795230, 16905099, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15795230, 16905099, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase type III" /protein_id="NP_387951.2" /db_xref="EnsemblGenomes-Gn:BSU00700" /db_xref="EnsemblGenomes-Tr:CAB11846" /db_xref="GOA:P37564" /db_xref="InterPro:IPR004619" /db_xref="SubtiList:BG10133" /db_xref="UniProtKB/Swiss-Prot:P37564" /translation="MLLVIDVGNTNTVLGVYHDGKLEYHWRIETSRHKTEDEFGMILR SLFDHSGLMFEQIDGIIISSVVPPIMFALERMCTKYFHIEPQIVGPGMKTGLNIKYDN PKEVGADRIVNAVAAIHLYGNPLIVVDFGTATTYCYIDENKQYMGGAIAPGITISTEA LYSRAAKLPRIEITRPDNIIGKNTVSAMQSGILFGYVGQVEGIVKRMKWQAKQEPKVI ATGGLAPLIANESDCIDIVDPFLTLKGLELIYERNRVGSV*" gene 79092..79868 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" CDS 79880..80755 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11323724, 15023991; Product type f: factor" /codon_start=1 /transl_table=11 /product="disulfide bond chaperone (heat shock protein HSP33)" /protein_id="NP_387952.1" /db_xref="EnsemblGenomes-Gn:BSU00710" /db_xref="EnsemblGenomes-Tr:CAB11847" /db_xref="GOA:P37565" /db_xref="InterPro:IPR000397" /db_xref="InterPro:IPR016153" /db_xref="InterPro:IPR016154" /db_xref="PDB:1VZY" /db_xref="SubtiList:BG10134" /db_xref="UniProtKB/Swiss-Prot:P37565" /translation="MDYLVKALAYDGKVRAYAARTTDMVNEGQRRHGTWPTASAALGR TMTASLMLGAMLKGDDKLTVKIEGGGPIGAIVADANAKGEVRAYVSNPQVHFDLNEQG KLDVRRAVGTNGTLSVVKDLGLREFFTGQVEIVSGELGDDFTYYLVSSEQVPSSVGVG VLVNPDNTILAAGGFIIQLMPGTDDETITKIEQRLSQVEPISKLIQKGLTPEEILEEV LGEKPEILETMPVRFHCPCSKERFETAILGLGKKEIQDMIEEDGQAEAVCHFCNEKYL FTKEELEGLRDQTTR*" gene 79880..80755 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" CDS 80802..81695 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 15856219; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein chaperone accessory lipoproteinfactor" /protein_id="NP_387953.1" /db_xref="EnsemblGenomes-Gn:BSU00720" /db_xref="EnsemblGenomes-Tr:CAB11848" /db_xref="GOA:P37566" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR027304" /db_xref="SubtiList:BG10135" /db_xref="UniProtKB/Swiss-Prot:P37566" /translation="MKSRTIWTIILGALLVCCIAVAYTLTKSQAGASSSGESIATIGG KSVTREEWLKEMEDQYGKSTLEDMINVRVVEQLAKKNKLKISKSEVDREFLLIKAVNN SFYEDEHTTEKEWKDQIRYNILLEDLLTRDIDISNKELESFYNKNKELYQFDDSYRIR HIVVKDEEEAREVLKELKGGSSFEAVAAERSTDRYTSPYGGDLGFVTEASDNIPSAYI EEAKTLKEDEWSQEPIKVSNGYAIIQLKEKLKARTFSFDEVKDQIRRQIAMDQLGDKA TVKTLWKEADVSWFYGEKSTK*" gene 80802..81695 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" promotor_-35 81425..81430 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 81447..81465 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 81448 /Source="Nicolas_upshifts" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" promotor_-35 81694..81701 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 81716..81735 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 81723 /Source="Nicolas_upshifts" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" CDS 81771..82697 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" /EC_number="2.5.1.47" /EC_number="4.4.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 15760717, 16267287, 16513748, 17056751, 18974048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15760717, 16267287, 16513748, 17056751, 18974048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cysteine synthase" /protein_id="NP_387954.1" /db_xref="EnsemblGenomes-Gn:BSU00730" /db_xref="EnsemblGenomes-Tr:CAB11849" /db_xref="GOA:P37887" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10136" /db_xref="UniProtKB/Swiss-Prot:P37887" /translation="MVRVANSITELIGNTPIVKLNRLADENSADVYLKLEYMNPGSSV KDRIGLAMIEAAEKEGKLKAGNTIIEPTSGNTGIGLAMVAAAKGLKAILVMPDTMSME RRNLLRAYGAELVLTPGAEGMKGAIKKAEELAEKHGYFVPQQFNNPSNPEIHRQTTGK EIVEQFGDDQLDAFVAGIGTGGTITGAGEVLKEAYPSIKIYAVEPSDSPVLSGGKPGP HKIQGIGAGFVPDILNTEVYDEIFPVKNEEAFEYARRAAREEGILGGISSGAAIYAAL QVAKKLGKGKKVLAIIPSNGERYLSTPLYQFD*" gene 81771..82697 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" downshifts 82690 /Source="Nicolas_upshifts" /id="D35" /incds=0 /nref=156 /ntot=259 /MaxReadThrough="5.90023" /MaxDrop="5.38596" /score="41.7897705" /energy="-11.4" /TU="U72" /idTUdmin="U70" /TUdmin=10 /isTUend="TRUE" promotor_-35 82744..82752 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 82766..82774 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 82768 /Source="Nicolas_upshifts" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" promotor_-35 82796..82799 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 82814..82833 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 82824 /Source="Nicolas_upshifts" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" CDS 82864..84276 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" /EC_number="2.6.1.85" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 9084182, 16605270, 17114263, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase (para-aminobenzoate synthase)" /protein_id="NP_387955.1" /db_xref="EnsemblGenomes-Gn:BSU00740" /db_xref="EnsemblGenomes-Tr:CAB11850" /db_xref="GOA:P28820" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10137" /db_xref="UniProtKB/Swiss-Prot:P28820" /translation="MAQRRPAGKKIPFQKDSFLQQFEKLAQSRKHHVLLESARGGRYS IAGLDPIATVKGKDGITTIKHGDEMLFKEGDPLRAFHSWFKTLETETNHEFPDFQGGA IGFLSYDYARYIENFKMLSLDDLETPDIYFLVFDDIAVYDHQEESLWLITHVNGSDQE TADVKLSELEQMWLTELPAVTSREMKPETAGSFAAPFTEDGFSQAVEKIKQYIASGDV FQVNLSIRQSQSLSVHPYQIYKTLREVNPSPYMAYLETPDFQIICGSPELLVSKKGKL LETRPIAGTRSRGKTNEEDEALANELIHNEKERAEHVMLVDLERNDLGRVSRYGSVRV NEFMAIEKYSHVMHIVSNVQGELQDGYDAVDIIHAVFPGGTITGAPKVRTMEIIEELE PTRRGLYTGSIGWFGYNHDLQFNIVIRTIYATGGQAFMQSGAGVVIDSVPKHEYKESF KKAFAMQRALELSEEETKIR*" gene 82864..84276 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" promotor_-35 83666..83668 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 83686..83704 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 83692 /Source="Nicolas_upshifts" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" promotor_-35 84033..84040 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 84053..84072 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 84066 /Source="Nicolas_upshifts" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" CDS 84290..84874 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" /EC_number="2.6.1.85" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098056, 16605270, 17114263, 24847778; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase; anthranilatesynthase (subunit II)" /protein_id="NP_387956.1" /db_xref="EnsemblGenomes-Gn:BSU00750" /db_xref="EnsemblGenomes-Tr:CAB11851" /db_xref="GOA:P28819" /db_xref="InterPro:IPR006221" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10138" /db_xref="UniProtKB/Swiss-Prot:P28819" /translation="MILMIDNYDSFTYNLVQYLGELGEELVVKRNDSITIDEIEELSP DFLMISPGPCSPDEAGISLEAIKHFAGKIPIFGVCLGHQSIAQVFGGDVVRAERLMHG KTSDIEHDGKTIFEGLKNPLVATRYHSLIVKPETLPSCFTVTAQTKEGEIMAIRHNDL PIEGVQFHPESIMTSFGKEMLRNFIETYRKEVIA*" gene 84290..84874 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" CDS 84874..85755 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" /EC_number="4.1.3.38" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10876155, 1644759, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate pyruvate-lyase" /protein_id="NP_387957.1" /db_xref="EnsemblGenomes-Gn:BSU00760" /db_xref="EnsemblGenomes-Tr:CAB11852" /db_xref="GOA:P28821" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR017824" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10139" /db_xref="UniProtKB/Swiss-Prot:P28821" /translation="MIYVNGRYMEEKDAVLSPFDHGFLYGIGVFETFRLYEGCPFLLD WHIERLERALKDLQIEYTVSKHEILEMLDKLLKLNDIKDGNARVRLNISAGISDKGFV AQTYDKPTVLCFVNQLKPESLPLQKEGKVLSIRRNTPEGSFRLKSHHYLNNMYAKREI GNDPRVEGIFLTEDGAVAEGIISNVFWRKGRCIYTPSLDTGILDGVTRRFIIENAKDI GLELKTGRYELEALLTADEAWMTNSVLEIIPFTKIEEVNYGSQSGEATSALQLLYKKE IKNMIHEKGGRAWRSTQ*" gene 84874..85755 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" CDS 85737..86594 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" /EC_number="2.5.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 11007651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydropteroate synthase" /protein_id="NP_387958.1" /db_xref="EnsemblGenomes-Gn:BSU00770" /db_xref="EnsemblGenomes-Tr:CAB11853" /db_xref="GOA:P28822" /db_xref="InterPro:IPR000489" /db_xref="InterPro:IPR006390" /db_xref="InterPro:IPR011005" /db_xref="SubtiList:BG10140" /db_xref="UniProtKB/Swiss-Prot:P28822" /translation="MAQHTIDQTQVIHTKPSALSYKEKTLVMGILNVTPDSFSDGGKY DSLDKALLHAKEMIDDGAHIIDIGGESTRPGAECVSEDEEMSRVIPVIERITKELGVP ISVDTYKASVADEAVKAGASIINDIWGAKHDPKMASVAAEHNVPIVLMHNRPERNYND LLPDMLSDLMESVKIAVEAGVDEKNIILDPGIGFAKTYHDNLAVMNKLEIFSGLGYPV LLATSRKRFIGRVLDLPPEERAEGTGATVCLGIQKGCDIVRVHDVKQIARMAKMMDAM LNKGGVHHG*" gene 85737..86594 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" CDS 86587..86949 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" /EC_number="4.1.2.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16188473, 17176045, 17388809; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroneopterin aldolase" /protein_id="NP_387959.1" /db_xref="EnsemblGenomes-Gn:BSU00780" /db_xref="EnsemblGenomes-Tr:CAB11854" /db_xref="GOA:P28823" /db_xref="InterPro:IPR006156" /db_xref="InterPro:IPR006157" /db_xref="SubtiList:BG10141" /db_xref="UniProtKB/Swiss-Prot:P28823" /translation="MDKVYVEGMEFYGYHGVFTEENKLGQRFKVDLTAELDLSKAGQT DDLEQTINYAELYHVCKDIVEGEPVKLVETLAERIAGTVLGKFQPVQQCTVKVIKPDP PIPGHYKSVAIEITRKKS*" gene 86587..86949 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" CDS 86946..87449 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" /EC_number="2.7.6.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17029412; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase" /protein_id="NP_387960.1" /db_xref="EnsemblGenomes-Gn:BSU00790" /db_xref="EnsemblGenomes-Tr:CAB11855" /db_xref="GOA:P29252" /db_xref="InterPro:IPR000550" /db_xref="InterPro:IPR035907" /db_xref="SubtiList:BG10142" /db_xref="UniProtKB/Swiss-Prot:P29252" /translation="MNNIAYIALGSNIGDRETYLRQAVALLHQHAAVTVTKVSSIYET DPVGYEDQAQFLNMAVEIKTSLNPFELLELTQQIENELGRTREVRWGPRTADLDILLF NRENIETEQLIVPHPRMYERLFVLAPLAEICQQVEKEATSAETDQEGVRVWKQKSGVD EFVHSES*" gene 86946..87449 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" CDS 87401..87610 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_387961.1" /db_xref="EnsemblGenomes-Gn:BSU00800" /db_xref="EnsemblGenomes-Tr:CAB11856" /db_xref="GOA:O31417" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG12701" /db_xref="UniProtKB/Swiss-Prot:O31417" /translation="MEAEIWGRRIRAFRKLKGYTQEGFAKALGISVSILGEIERGNRL PSAAIIQDAADVLNISADELAPPEK*" gene 87401..87610 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" CDS 87634..88635 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 15698474, 26112661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase B" /protein_id="NP_387962.1" /db_xref="EnsemblGenomes-Gn:BSU00810" /db_xref="EnsemblGenomes-Tr:CAB11857" /db_xref="GOA:P37567" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR004652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG10143" /db_xref="UniProtKB/Swiss-Prot:P37567" /translation="MFKIGDIQLKNRVVLAPMAGVCNSAFRLTVKEFGAGLVCAEMVS DKAILYNNARTMGMLYIDEREKPLSLQIFGGKKETLVEAAKFVDQNTTADIIDINMGC PVPKITKCDAGAKWLLDPDKIYEMVSAVVDAVNKPVTVKMRMGWDEDHIFAVKNAQAV ERAGGKAVALHGRTRVQMYEGTANWDIIKEVKQSVSIPVIGNGDVKTPQDAKRMLDET GVDGVMIGRAALGNPWMIYRTVQYLETGKLKEEPQVREKMAVCKLHLDRLIDLKGENV AVREMRKHAAWYLKGVKGNANVRNEINHCETREEFVQLLDAFTVEVEAKELQNAKVG* " gene 87634..88635 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" S_feature complement(88050..89566) /Source="Nicolas_S_feature" /locus_tag="new_88050_89566_c" /HighExp="LoTm, C30, S6, S8, S5, S7, S3, S4, C90, G135" /AntisenseName="dusB" /AntisenseCor="-0.60218706634778196" /AntisenseRegPval="-27.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S41" S_feature 88636..88726 /Source="Nicolas_S_feature" /locus_tag="new_88636_88726" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, Diami, C30, LBGexp, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="SigA, SigI, SigA, SigEF, SigA, SigA, SigA" /TUlongPSig="0.621, 0.787, 1, 0.995, 1, 0.999, 1" /label="S42" CDS 88727..90226 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" /EC_number="6.1.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14623972, 20649968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14623972, 20649968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lysyl-tRNA synthetase" /protein_id="NP_387963.1" /db_xref="EnsemblGenomes-Gn:BSU00820" /db_xref="EnsemblGenomes-Tr:CAB11858" /db_xref="GOA:P37477" /db_xref="InterPro:IPR002313" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018149" /db_xref="InterPro:IPR034762" /db_xref="SubtiList:BG10144" /db_xref="UniProtKB/Swiss-Prot:P37477" /translation="MSQEEHNHEELNDQLQVRRDKMNQLRDNGIDPFGARFERTHQSQ EVISAYQDLTKEELEEKAIEVTIAGRMMTKRGKGKAGFAHLQDLEGQIQIYVRKDSVG DDQYEIFKSSDLGDLIGVTGKVFKTNVGELSVKATSFELLTKALRPLPDKYHGLKDVE QRYRQRYLDLIVNPDSKHTFITRSKIIQAMRRYLDDHGYLEVETPTMHSIPGGASARP FITHHNALDIPLYMRIAIELHLKRLIVGGLEKVYEIGRVFRNEGVSTRHNPEFTMIEL YEAYADYKDIMSLTENLVAHIAQEVLGTTTIQYGEEQIDLKPEWKRIHMVDAVKEATG VDFWEEVTVEQAREYAKEHEVEIKDSMTVGHIINEFFEQKIEETLIQPTFIYGHPVEI SPLAKKNPEDPRFTDRFELFIVGREHANAFTELNDPIDQRERFEAQLKEREAGNDEAH LMDEDFVEALEYGMPPTGGLGIGIDRLVMLLTNAPSIRDVLLFPQMRQR*" gene 88727..90226 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" promotor_-10 complement(89550..89568) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(89566) /Source="Nicolas_upshifts" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" promotor_-35 complement(89584..89589) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 90207 /Source="Nicolas_upshifts" /id="D36" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="4.49559" /MaxDrop="4.89484" /score="4.33485487" /energy="-18.1" /TU="U76" /idTUdmin="U74" /TUdmin=3 /isTUend="TRUE" promotor_-35 90302..90309 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 90318..90535 /Source="Nicolas_S_feature" /locus_tag="new_90318_90535" /HighExp="LBGstat, H2O2, Oxctl, Diami, dia15, Paraq, MG 25, Heat, MG 15, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 0.998, 1, 1, 0.999, 1" /label="S43" upshifts 90318 /Source="Nicolas_upshifts" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" promotor_-10 90323..90342 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(90368) /Source="Nicolas_upshifts" /id="D37" /incds=0 /nref=3 /ntot=51 /MaxReadThrough="3.16217" /MaxDrop="5.0092" /score="18.6635354" /energy="-16.9" /TU="NA" /idTUdmin="U77" /TUdmin="-2288" /isTUend="FALSE" rRNA 90536..92089 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 90536..92089 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" rRNA 92254..95181 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 92254..95181 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" rRNA 95237..95354 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 95237..95354 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" tRNA 95375..95450 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 95375..95450 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" tRNA 95455..95530 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 95455..95530 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" tRNA 95567..95642 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 95567..95642 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" tRNA 95649..95731 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 95649..95731 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" tRNA 95772..95846 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 95772..95846 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" tRNA 95861..95946 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 95861..95946 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" tRNA 95956..96032 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA(ACG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" gene 95956..96032 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" tRNA 96060..96136 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Pro(UGG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 96060..96136 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" tRNA 96146..96221 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 96146..96221 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" rRNA 96392..97945 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 96392..97945 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" rRNA 98110..101037 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 98110..101037 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" rRNA 101093..101211 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 101093..101211 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" S_feature 101212..101289 /Source="Nicolas_S_feature" /locus_tag="new_101212_101289" /HighExp="G135, G180, G150, Cold, Paraq, Oxctl, H2O2, C30, BMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S44" promotor_-35 101259..101262 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 101278..101297 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 101291 /Source="Nicolas_upshifts" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" promotor_-35 101325..101331 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-35" promotor_-10 101345..101364 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-10" upshifts 101356 /Source="Nicolas_upshifts" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" promotor_-35 101371..101378 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 101392..101411 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 101404 /Source="Nicolas_upshifts" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" CDS 101449..101913 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of class III stress genes" /protein_id="NP_387964.1" /db_xref="EnsemblGenomes-Gn:BSU00830" /db_xref="EnsemblGenomes-Tr:CAB11859" /db_xref="GOA:P37568" /db_xref="InterPro:IPR008463" /db_xref="SubtiList:BG10145" /db_xref="UniProtKB/Swiss-Prot:P37568" /translation="MGHNISDIIEQYLKRVLDQNGKEILEIKRSEIADKFQCVPSQIN YVINTRFTSERGYIVESKRGGGGYIRIIKIKMNNEVVLINNIISQINTHLSQAASDDI ILRLLEDKVISEREAKMMVSVMDRSVLHIDLPERDELRARMMKAMLTSLKLK*" gene 101449..101913 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" misc_feature complement(101560..101564) /Source="Nicolas_upshift_promotors" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(101566) /Source="Nicolas_upshifts" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 101927..102484 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 19189946, 24947607" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 19189946, 24947607; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of protein kinase McsB" /protein_id="NP_387965.1" /db_xref="EnsemblGenomes-Gn:BSU00840" /db_xref="EnsemblGenomes-Tr:CAB11860" /db_xref="GOA:P37569" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR025542" /db_xref="InterPro:IPR029037" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10146" /db_xref="UniProtKB/Swiss-Prot:P37569" /translation="MICQECHERPATFHFTKVVNGEKIEVHICEQCAKENSDSYGISA NQGFSIHNLLSGLLNMDSSFQNAGTQMFSHSEQISACPKCGMTFQQFRKIGRFGCSEC YKTFHSNITPILRKVHSGNTVHAGKIPKRIGGNLHVRRQIDMLKKELESLIHQEEFEN AAHVRDQIRLLEQSLKSTDSEEEQE*" gene 101927..102484 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" CDS 102484..103575 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" /EC_number="2.7.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 17380125, 19189946, 21622759, 25610436, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 17380125, 19189946, 21622759, 25610436, 27749819; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein arginine kinase" /protein_id="NP_387966.1" /db_xref="EnsemblGenomes-Gn:BSU00850" /db_xref="EnsemblGenomes-Tr:CAB11861" /db_xref="GOA:P37570" /db_xref="InterPro:IPR000749" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR022414" /db_xref="InterPro:IPR022415" /db_xref="InterPro:IPR023660" /db_xref="SubtiList:BG10147" /db_xref="UniProtKB/Swiss-Prot:P37570" /translation="MSLKHFIQDALSSWMKQKGPESDIVLSSRIRLARNFEHIRFPTR YSNEEASSIIQQFEDQFSEQEIPGIGKFVLIRMNDAQPLEKRVLVEKHLISPNLTESP FGGCLLSENEEVSVMLNEEDHIRIQCLFPGFQLLEAMKAANQVDDWIEEKVDYAFNEQ RGYLTSCPTNVGTGLRASVMMHLPALVLTRQINRIIPAINQLGLVVRGIYGEGSEAVG NIFQISNQITLGKSEQDIVEDLNSVAAQLIEQERSAREAIYQTSKIELEDRVYRSYGV LSNCRMIESKETAKCLSDVRLGIDLGIIKGLSSNILNELMILTQPGFLQQYSGGALRP NERDIRRAALIRERLHLEMNGKRQEDESI*" gene 102484..103575 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" CDS 103572..106004 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354604, 15529410, 16525504, 26735940, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354604, 15529410, 16525504, 26735940, 27749819; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III stress response-related ATPase, AAA+ superfamily" /protein_id="NP_387967.1" /db_xref="EnsemblGenomes-Gn:BSU00860" /db_xref="EnsemblGenomes-Tr:CAB11862" /db_xref="GOA:P37571" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004176" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="InterPro:IPR036628" /db_xref="PDB:2K77" /db_xref="PDB:2Y1Q" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="PDB:5HBN" /db_xref="SubtiList:BG10148" /db_xref="UniProtKB/Swiss-Prot:P37571" /translation="MMFGRFTERAQKVLALAQEEALRLGHNNIGTEHILLGLVREGEG IAAKALQALGLGSEKIQKEVESLIGRGQEMSQTIHYTPRAKKVIELSMDEARKLGHSY VGTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGSNETGSSAAGTNSNANT PTLDSLARDLTAIAKEDSLDPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIA EGLAQQIINNEVPEILRDKRVMTLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIIL FIDELHTLIGAGGAEGAIDASNILKPSLARGELQCIGATTLDEYRKYIEKDAALERRF QPIQVDQPSVDESIQILQGLRDRYEAHHRVSITDDAIEAAVKLSDRYISDRFLPDKAI DLIDEAGSKVRLRSFTTPPNLKELEQKLDEVRKEKDAAVQSQEFEKAASLRDTEQRLR EQVEDTKKSWKEKQGQENSEVTVDDIAMVVSSWTGVPVSKIAQTETDKLLNMENILHS RVIGQDEAVVAVAKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAESIFGDE ESMIRIDMSEYMEKHSTSRLVGSPPGYVGYDEGGQLTEKVRRKPYSVVLLDEIEKAHP DVFNILLQVLEDGRLTDSKGRTVDFRNTILIMTSNVGASELKRNKYVGFNVQDETQNH KDMKDKVMGELKRAFRPEFINRIDEIIVFHSLEKKHLTEIVSLMSDQLTKRLKEQDLS IELTDAAKAKVAEEGVDLEYGARPLRRAIQKHVEDRLSEELLRGNIHKGQHIVLDVED GEFVVKTTAKTN*" gene 103572..106004 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" downshifts 105999 /Source="Nicolas_upshifts" /id="D38" /incds=0 /nref=57 /ntot=245 /MaxReadThrough="6.69446" /MaxDrop="4.4703" /score="-8.32149463" /energy="-11.7" /TU="U80,U81" /idTUdmin="U79" /TUdmin="-1" /isTUend="TRUE" CDS 106096..107472 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" /EC_number="2.1.1.63" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931349, 11810266, 15317759, 25616256; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair protein; 6-O-methylguanine-DNA methyltransferase" /protein_id="NP_387968.1" /db_xref="EnsemblGenomes-Gn:BSU00870" /db_xref="EnsemblGenomes-Tr:CAB11863" /db_xref="GOA:P37572" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004504" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10149" /db_xref="UniProtKB/Swiss-Prot:P37572" /translation="MAKTKSKFICQSCGYESPKWMGKCPGCGAWNTMVEEMIKKAPAN RRAAFSHSVQTVQKPSPITSIETSEEPRVKTQLGEFNRVLGGGVVKGSLVLIGGDPGI GKSTLLLQVSAQLSGSSNSVLYISGEESVKQTKLRADRLGINNPSLHVLSETDMEYIS SAIQEMNPSFVVVDSIQTVYQSDITSAPGSVSQVRECTAELMKIAKTKGIPIFIVGHV TKEGSIAGPRLLEHMVDTVLYFEGERHHTFRILRAVKNRFGSTNEMGIFEMREEGLTE VLNPSEIFLEERSAGSAGSSITASMEGTRPILVEIQALISPTSFGNPRRMATGIDHNR VSLLMAVLEKRVGLLLQNQDAYLKVAGGVKLDEPAIDLAIVISIASSFRDTPPNPADC FIGEVGLTGEVRRVSRIEQRVKEAAKLGFKRMIIPAANLDGWTKPKGIEVIGVANVAE ALRTSLGG*" gene 106096..107472 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" promotor_-35 106551..106560 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 106573..106588 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 106576 /Source="Nicolas_upshifts" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" CDS 107476..108558 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase; DNA integrity scanning protein; cell cycle checkpoint DNA scanning protein" /protein_id="NP_387969.1" /db_xref="EnsemblGenomes-Gn:BSU00880" /db_xref="EnsemblGenomes-Tr:CAB11864" /db_xref="GOA:P37573" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR018906" /db_xref="InterPro:IPR023763" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG10150" /db_xref="UniProtKB/Swiss-Prot:P37573" /translation="MEKEKKGAKHELDLSSILQFVAPGTPLRAGMENVLRANTGGLIV VGYNDKVKEVVDGGFHINTAFSPAHLYELAKMDGAIILSDSGQKILYANTQLMPDATI SSSETGMRHRTAERVAKQTGCLVIAISERRNVITLYQENMKYTLKDIGFILTKANQAI QTLEKYKTILDKTINALNALEFEELVTFSDVLSVMHRYEMVLRIKNEINMYIKELGTE GHLIKLQVIELITDMEEEAALFIKDYVKEKIKDPFVLLKELQDMSSYDLLDDSIVYKL LGYPASTNLDDYVLPRGYRLLNKIPRLPMPIVENVVEAFGVLPRIIEASAEELDEVEG IGEVRAQKIKKGLKRLQEKHYLDRQL*" gene 107476..108558 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" S_feature 108559..108673 /Source="Nicolas_S_feature" /locus_tag="new_108559_108673" /HighExp="Etha, Salt, Heat, dia15, Diami, M9-stat, B60, T-0.40H, T-1.10H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.947" /label="S45" CDS 108674..109774 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26999498; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein possibly involved in RNA binding" /protein_id="NP_387970.1" /db_xref="EnsemblGenomes-Gn:BSU00890" /db_xref="EnsemblGenomes-Tr:CAB11865" /db_xref="GOA:Q06754" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG10151" /db_xref="UniProtKB/Swiss-Prot:Q06754" /translation="MLKRIVQAFFIIFGGVVGIFLIPELFVLLNIQDIPLITNAYTSA AIGAIIFFLISIWGTEYVVNWVKWIEDSLLKAPVPDLLFGSLGLVFGLIIAYLIVNVI PLDNIPYRIFSTIIPVFLAFFLGYLGFQVGFKKKDELISLFSISARMQKKKGTADEEH EVQDKKLKILDTSVIIDGRIADICQTGFLEGVIVIPQFVLEELQHIADSSDVLKRNRG RRGLDILNRIQKELDIEVEIYEGDFEDIQEVDSKLVKLAKLTSGVVVTNDFNLNKVCE LQKVAVLNINDLANAVKPVVLPGEEMNVQVIKDGKEHNQGVAYLDDGTMIVVEEGRNY IGKHIDVLVTSVLQTAAGRMIFAKPKLLEKAL*" gene 108674..109774 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" downshifts complement(109596) /Source="Nicolas_upshifts" /id="D39" /incds=1 /nref=1 /ntot=103 /MaxReadThrough="0.39171" /MaxDrop="2.87304" /score="-9.71423487" /energy="-11.8" /TU="NA" /idTUdmin="U82" /TUdmin="-8228" /isTUend="FALSE" CDS 109789..110487 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" /EC_number="2.7.7.60" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, nonmevalonate isoprenoid pathway" /protein_id="NP_387971.1" /db_xref="EnsemblGenomes-Gn:BSU00900" /db_xref="EnsemblGenomes-Tr:CAB11866" /db_xref="GOA:Q06755" /db_xref="InterPro:IPR001228" /db_xref="InterPro:IPR018294" /db_xref="InterPro:IPR029044" /db_xref="InterPro:IPR034683" /db_xref="PDB:5DDT" /db_xref="PDB:5DDV" /db_xref="PDB:5HS2" /db_xref="SubtiList:BG10152" /db_xref="UniProtKB/Swiss-Prot:Q06755" /translation="MSYDVVIPAAGQGKRMKAGRNKLFIELKGDPVIIHTLRVFDSHR QCDKIILVINEQEREHFQQLLSDYPFQTSIELVAGGDERQHSVYKGLKAVKQEKIVLV HDGARPFIKHEQIDELIAEAEQTGAAILAVPVKDTIKRVQDLQVSETIERSSLWAVQT PQAFRLSLLMKAHAEAERKGFLGTDDASLVEQMEGGSVRVVEGSYTNIKLTTPDDLTS AEAIMESESGNKHV*" gene 109789..110487 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" CDS 110480..110956 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" /EC_number="4.6.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9622350, 11997478, 12270818, 12682299, 17458547, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 11997478, 12270818, 12682299, 17458547, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase" /protein_id="NP_387972.1" /db_xref="EnsemblGenomes-Gn:BSU00910" /db_xref="EnsemblGenomes-Tr:CAB11867" /db_xref="GOA:Q06756" /db_xref="InterPro:IPR003526" /db_xref="InterPro:IPR020555" /db_xref="InterPro:IPR036571" /db_xref="PDB:5IWX" /db_xref="PDB:5IWY" /db_xref="SubtiList:BG10153" /db_xref="UniProtKB/Swiss-Prot:Q06756" /translation="MFRIGQGFDVHQLVEGRPLIIGGIEIPYEKGLLGHSDADVLLHT VADACLGAVGEGDIGKHFPDTDPEFKDADSFKLLQHVWGIVKQKGYVLGNIDCTIIAQ KPKMLPYIEDMRKRIAEGLEADVSQVNVKATTTEKLGFTGRAEGIAAQATVLIQKG*" gene 110480..110956 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" promotor_-35 110960..110967 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 110981..111000 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 110994 /Source="Nicolas_upshifts" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" CDS 111047..112498 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" /EC_number="6.1.1.24" /EC_number="6.1.1.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA synthetase" /protein_id="NP_387973.1" /db_xref="EnsemblGenomes-Gn:BSU00920" /db_xref="EnsemblGenomes-Tr:CAB11868" /db_xref="GOA:P22250" /db_xref="InterPro:IPR000924" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR004527" /db_xref="InterPro:IPR008925" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020058" /db_xref="InterPro:IPR020061" /db_xref="InterPro:IPR020751" /db_xref="InterPro:IPR020752" /db_xref="InterPro:IPR033910" /db_xref="SubtiList:BG10154" /db_xref="UniProtKB/Swiss-Prot:P22250" /translation="MGNEVRVRYAPSPTGHLHIGNARTALFNYLFARNQGGKFIIRVE DTDKKRNIEGGEQSQLNYLKWLGIDWDESVDVGGEYGPYRQSERNDIYKVYYEELLEK GLAYKCYCTEEELEKEREEQIARGEMPRYSGKHRDLTQEEQEKFIAEGRKPSIRFRVP EGKVIAFNDIVKGEISFESDGIGDFVIVKKDGTPTYNFAVAIDDYLMKMTHVLRGEDH ISNTPKQIMIYQAFGWDIPQFGHMTLIVNESRKKLSKRDESIIQFIEQYKELGYLPEA LFNFIGLLGWSPVGEEELFTKEQFIEIFDVNRLSKSPALFDMHKLKWVNNQYVKKLDL DQVVELTLPHLQKAGKVGTELSAEEQEWVRKLISLYHEQLSYGAEIVELTDLFFTDEI EYNQEAKAVLEEEQVPEVLSTFAAKLEELEEFTPDNIKASIKAVQKETGHKGKKLFMP IRVAVTGQTHGPELPQSIELIGKETAIQRLKNI*" gene 111047..112498 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" promotor_-35 111976..111985 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-35" promotor_-10 111999..112018 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-10" upshifts 111999 /Source="Nicolas_upshifts" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" S_feature 112499..112799 /Source="Nicolas_S_feature" /locus_tag="new_112499_112799" /HighExp="S6, S8, S7, Diami, C90, LBGexp, G135, H2O2, dia5, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.17844199999999999" /TUshortSig="SigK, SigA, SigWXY" /TUshortPSig="1, 0.999, 1" /TUlongSig="SigA, SigB, SigA" /TUlongPSig="1, 1, 0.947" /label="S46" CDS 112800..113453 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" /EC_number="2.3.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7510287, 10737181, 10939241, 17056751, 18974048, 25731080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7510287, 10737181, 10939241, 17056751, 18974048, 25731080; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine O-acetyltransferase" /protein_id="NP_387974.1" /db_xref="EnsemblGenomes-Gn:BSU00930" /db_xref="EnsemblGenomes-Tr:CAB11869" /db_xref="GOA:Q06750" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005881" /db_xref="InterPro:IPR010493" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="SubtiList:BG10155" /db_xref="UniProtKB/Swiss-Prot:Q06750" /translation="MFFRMLKEDIDTVFDQDPAARSYFEVILTYSGLHAIWAHRIAHA LYKRKFYFLARLISQVSRFFTGIEIHPGATIGRRFFIDHGMGVVIGETCEIGNNVTVF QGVTLGGTGKEKGKRHPTIKDDALIATGAKVLGSITVGEGSKIGAGSVVLHDVPDFST VVGIPGRVVVQNGKKVRRDLNHQDLPDPVADRFKSLEQQILELKAELEDRKERINQK* " gene 112800..113453 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" CDS 113450..114850 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" /EC_number="6.1.1.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10024179, 10546897, 10931887, 12682299, 29079736" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024179, 10546897, 10931887, 12682299, 29079736; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual cysteinyl-tRNA synthetase; cysteine persulfide synthase" /protein_id="NP_387975.1" /db_xref="EnsemblGenomes-Gn:BSU00940" /db_xref="EnsemblGenomes-Tr:CAB11870" /db_xref="GOA:Q06752" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015273" /db_xref="InterPro:IPR015803" /db_xref="InterPro:IPR024909" /db_xref="InterPro:IPR032678" /db_xref="SubtiList:BG10156" /db_xref="UniProtKB/Swiss-Prot:Q06752" /translation="MTITLYNTLTRQKETFVPLEEGKVKMYVCGPTVYNYIHIGNARP AIVYDTVRNYLEYKGYDVQYVSNFTDVDDKLIKAANELGEDVPTISERFIKAYFEDVG ALGCRKADLHPRVMENMDAIIEFVDQLVKKGYAYESEGDVYFKTRAFEGYGKLSQQSI DELRSGARIRVGEKKEDALDFALWKAAKEGEISWDSPWGKGRPGWHIECSAMVKKYLG DQIDIHAGGQDLTFPHHENEIAQSEALTGKTFAKYWLHNGYINIDNEKMSKSLGNFVL VHDIIKQHDPQLLRFFMLSVHYRHPINYSEELLENTKSAFSRLKTAYSNLQHRLNSST NLTEDDDQWLEKVEEHRKAFEEEMDDDFNTANAISVLFDLAKHANYYLQKDHTADHVI TAFIEMFDRIVSVLGFSLGEQELLDQEIEDLIEKRNEARRNRDFALSDQIRDQLKSMN IILEDTAQGTRWKRGE*" gene 113450..114850 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" CDS 114854..115285 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 25634891, 27924926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 25634891, 27924926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease for 23S RNA maturation, mini-RNase III" /protein_id="NP_387976.1" /db_xref="EnsemblGenomes-Gn:BSU00950" /db_xref="EnsemblGenomes-Tr:CAB11871" /db_xref="GOA:O31418" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR008226" /db_xref="InterPro:IPR036389" /db_xref="PDB:4OUN" /db_xref="SubtiList:BG12702" /db_xref="UniProtKB/Swiss-Prot:O31418" /translation="MLEFDTIKDSKQLNGLALAYIGDAIFEVYVRHHLLKQGFTKPND LHKKSSRIVSAKSQAEILFFLQNQSFFTEEEEAVLKRGRNAKSGTTPKNTDVQTYRYS TAFEALLGYLFLEKKEERLSQLVAEAIQFGTSGRKTNESAT*" gene 114854..115285 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" CDS 115269..116018 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" /EC_number="2.1.1.185" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11698387, 12377117, 16014871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA (Gm2251)-methyltransferase" /protein_id="NP_387977.1" /db_xref="EnsemblGenomes-Gn:BSU00960" /db_xref="EnsemblGenomes-Tr:CAB11872" /db_xref="GOA:Q06753" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR004441" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG10157" /db_xref="UniProtKB/Swiss-Prot:Q06753" /translation="MSQQHDYVIGKNAVIETLKSDRKLYKLWMAENTVKGQAQQVIEL AKKQGITIQYVPRKKLDQMVTGQHQGVVAQVAAYEYAELDDLYKAAEEKNEQPFFLIL DELEDPHNLGSIMRTADAVGAHGIVIPKRRAVGLTTTVAKASTGAIEHIPVARVTNLA RTLEEMKERGIWVVGTDASAREDFRNMDGNMPLALVIGSEGKGMGRLVKEKCDFLIKL PMAGKVTSLNASVAAGLLMYEVYRKRNPVGE*" gene 115269..116018 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" CDS 116025..116537 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17114934, 23355615, 28363943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17114934, 23355615, 28363943; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-dependent mRNA endonuclease" /protein_id="NP_387978.1" /db_xref="EnsemblGenomes-Gn:BSU00970" /db_xref="EnsemblGenomes-Tr:CAB11873" /db_xref="InterPro:IPR010298" /db_xref="PDB:5MQ8" /db_xref="PDB:5MQ9" /db_xref="SubtiList:BG10158" /db_xref="UniProtKB/Swiss-Prot:P37574" /translation="MDILLVDGYNMIGAWPQLKDLKANSFEEARDVLIQKMAEYQSYT GNRVIVVFDAHLVKGLEKKQTNHRVEVIFTKENETADERIEKLAQALNNIATQIHVAT SDYTEQWAIFGQGALRKSARELLREVETIERRIERRVRKITSEKPAGKIALSEEVLKT FEKWRRGDLD*" gene 116025..116537 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" promotor_-35 116536..116543 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 116558..116577 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 116560 /Source="Nicolas_upshifts" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" CDS 116600..117256 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169614, 16339734, 25288929, 26712348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169614, 16339734, 25288929, 26712348; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-30 factor (sigma(H))" /protein_id="NP_387979.1" /db_xref="EnsemblGenomes-Gn:BSU00980" /db_xref="EnsemblGenomes-Tr:CAB11874" /db_xref="GOA:P17869" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014218" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR016371" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10159" /db_xref="UniProtKB/Swiss-Prot:P17869" /translation="MNLQNNKGKFNKEQFCQLEDEQVIEKVHVGDSDALDYLITKYRN FVRAKARSYFLIGADREDIVQEGMIGLYKSIRDFKEDKLTSFKAFAELCITRQIITAI KTATRQKHIPLNSYASLDKPIFDEESDRTLLDVISGAKTLNPEEMIINQEEFDDIEMK MGELLSDLERKVLVLYLDGRSYQEISDELNRHVKSIDNALQRVKRKLEKYLEIREISL *" gene 116600..117256 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" downshifts complement(117054) /Source="Nicolas_upshifts" /id="D40" /incds=1 /nref=1 /ntot=107 /MaxReadThrough="2.38622" /MaxDrop="2.50464" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=836 /isTUend="FALSE" S_feature 117257..117348 /Source="Nicolas_S_feature" /locus_tag="new_117257_117348" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, S1, S2, T5.0H, HiOs, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S47" CDS 117349..117498 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586115, 19648245, 23002217, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586115, 19648245, 23002217, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_387980.1" /db_xref="EnsemblGenomes-Gn:BSU00990" /db_xref="EnsemblGenomes-Tr:CAB11875" /db_xref="GOA:Q06798" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="SubtiList:BG10160" /db_xref="UniProtKB/Swiss-Prot:Q06798" /translation="MRKKITLACKTCGNRNYTTMKSSASAAERLEVKKYCSTCNSHTA HLETK*" gene 117349..117498 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" CDS 117532..117711 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11976315, 12682299, 16242710, 22304380, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11976315, 12682299, 16242710, 22304380, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_387981.1" /db_xref="EnsemblGenomes-Gn:BSU01000" /db_xref="EnsemblGenomes-Tr:CAB11876" /db_xref="GOA:Q06799" /db_xref="InterPro:IPR001901" /db_xref="InterPro:IPR005807" /db_xref="InterPro:IPR022943" /db_xref="SubtiList:BG10161" /db_xref="UniProtKB/Swiss-Prot:Q06799" /translation="MRIMKFFKDVGKEMKKVSWPKGKELTRYTITVISTVIFFVIFFA LLDTGISQLIRLIVE*" gene 117532..117711 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" S_feature 117712..117889 /Source="Nicolas_S_feature" /locus_tag="new_117712_117889" /HighExp="Cold, G180, G150, H2O2, LoTm, Oxctl, G135, Paraq, LBGexp, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S48" downshifts complement(117883) /Source="Nicolas_upshifts" /id="D41" /incds=0 /nref=37 /ntot=175 /MaxReadThrough="1.57397" /MaxDrop="4.03552" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=7 /isTUend="TRUE" CDS 117890..118423 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11101662, 16014871, 16707701, 18852477, 26742846, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101662, 16014871, 16707701, 18852477, 26742846, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase elongation pause factor" /protein_id="NP_387982.1" /db_xref="EnsemblGenomes-Gn:BSU01010" /db_xref="EnsemblGenomes-Tr:CAB11877" /db_xref="GOA:Q06795" /db_xref="InterPro:IPR001062" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR006645" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015869" /db_xref="InterPro:IPR036735" /db_xref="SubtiList:BG10162" /db_xref="UniProtKB/Swiss-Prot:Q06795" /translation="MEKNWYVVHTYSGYENKVKANLEKRVESMGMQDKIFRVVVPEEE ETDIKNGKKKVVKKKVFPGYVLVEIVMTDDSWYVVRNTPGVTGFVGSAGSGSKPTPLL PGEAETILKRMGMDERKTDIDFELKETVKVIDGPFANFTGSIEEIDYDKSKVKVFVNM FGRETPVELEFTQIDKL*" gene 117890..118423 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" upshifts complement(117978) /Source="Nicolas_upshifts" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(117981..117985) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(118000..118005) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 118434..118441 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 118452..118590 /Source="Nicolas_S_feature" /locus_tag="new_118452_118590" /HighExp="T-1.40H, ferm, T-3.40H, T-5.40H, BI, B36, LoTm, SMM, T-2.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S49" upshifts 118452 /Source="Nicolas_upshifts" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" promotor_-10 118455..118474 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 118591..119016 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11244072, 19653700, 20441189" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244072, 19653700, 20441189; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 (BL11)" /protein_id="NP_387983.2" /db_xref="EnsemblGenomes-Gn:BSU01020" /db_xref="EnsemblGenomes-Tr:CAB11878" /db_xref="GOA:Q06796" /db_xref="InterPro:IPR000911" /db_xref="InterPro:IPR006519" /db_xref="InterPro:IPR020783" /db_xref="InterPro:IPR020784" /db_xref="InterPro:IPR020785" /db_xref="InterPro:IPR036769" /db_xref="InterPro:IPR036796" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG10163" /db_xref="UniProtKB/Swiss-Prot:Q06796" /translation="MAKKVVKVVKLQIPAGKANPAPPVGPALGQAGVNIMGFCKEFNA RTADQAGLIIPVEISVYEDRSFTFITKTPPAAVLLKKAAGIESGSGEPNRNKVATVKR DKVREIAETKMPDLNAADVEAAMRMVEGTARSMGIVIED*" gene 118591..119016 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" S_feature 119017..119110 /Source="Nicolas_S_feature" /locus_tag="new_119017_119110" /HighExp="HPh, LPh, Lbexp, G180, LBGexp, G150, Heat, Cold, Fru, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S50" CDS 119111..119809 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16352840, 17981968, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L1 (BL1)" /protein_id="NP_387984.2" /db_xref="EnsemblGenomes-Gn:BSU01030" /db_xref="EnsemblGenomes-Tr:CAB11879" /db_xref="GOA:Q06797" /db_xref="InterPro:IPR002143" /db_xref="InterPro:IPR005878" /db_xref="InterPro:IPR016095" /db_xref="InterPro:IPR023673" /db_xref="InterPro:IPR023674" /db_xref="InterPro:IPR028364" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="SubtiList:BG10164" /db_xref="UniProtKB/Swiss-Prot:Q06797" /translation="MAKKGKKYVEAAKLVDRSKAYDVSEAVALVKKTNTAKFDATVEV AFRLGVDPRKNDQQIRGAVVLPNGTGKTQRVLVFAKGEKAKEAEAAGADFVGDTDYIN KIQQGWFDFDVIVATPDMMGEVGKIGRVLGPKGLMPNPKTGTVTFEVEKAIGEIKAGK VEYRVDKAGNIHVPIGKVSFEDEKLVENFTTMYDTILKAKPAAAKGVYVKNVAVTSTM GPGVKVDSSTFNVK*" gene 119111..119809 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" downshifts complement(119783) /Source="Nicolas_upshifts" /id="D42" /incds=0 /nref=3 /ntot=95 /MaxReadThrough="3.54108" /MaxDrop="3.36566" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U89" /TUdmin=0 /isTUend="TRUE" misc_RNA 119855..119995 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" /product="L10_leader" /experiment="publication(s) with functional evidences, PMID:26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26101249; Product type n: RNA" gene 119855..119995 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" upshifts complement(119871) /Source="Nicolas_upshifts" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(119874..119878) /Source="Nicolas_upshift_promotors" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 119927 /Source="Nicolas_upshifts" /id="D43" /incds=1 /nref=1 /ntot=19 /MaxReadThrough="9.14839" /MaxDrop="2.9211" /score="20.0562348" /energy="-13.2" /TU="U88" /idTUdmin="U84" /TUdmin=1497 /isTUend="FALSE" CDS 120061..120561 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9810686, 11341315, 12682299, 18247578, 26101249, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9810686, 11341315, 12682299, 18247578, 26101249, 22720735; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L10 (BL5)" /protein_id="NP_387985.2" /db_xref="EnsemblGenomes-Gn:BSU01040" /db_xref="EnsemblGenomes-Tr:CAB11880" /db_xref="GOA:P42923" /db_xref="InterPro:IPR001790" /db_xref="InterPro:IPR002363" /db_xref="InterPro:IPR022973" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11220" /db_xref="UniProtKB/Swiss-Prot:P42923" /translation="MSSAIETKKVVVEEIASKLKESKSTIIVDYRGLNVSEVTELRKQ LREANVEFKVYKNTMTRRAVEQAELNGLNDFLTGPNAIAFSTEDVVAPAKVLNDFAKN HEALEIKAGVIEGKVSTVEEVKALAELPSREGLLSMLLSVLQAPVRNLALAAKAVAEQ KEEQGA*" gene 120061..120561 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" CDS 120607..120978 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 6771249, 8755892, 26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 6771249, 8755892, 26101249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L12 (BL9)" /protein_id="NP_387986.1" /db_xref="EnsemblGenomes-Gn:BSU01050" /db_xref="EnsemblGenomes-Tr:CAB11881" /db_xref="GOA:P02394" /db_xref="InterPro:IPR000206" /db_xref="InterPro:IPR008932" /db_xref="InterPro:IPR013823" /db_xref="InterPro:IPR014719" /db_xref="InterPro:IPR036235" /db_xref="SubtiList:BG10726" /db_xref="UniProtKB/Swiss-Prot:P02394" /translation="MALNIEEIIASVKEATVLELNDLVKAIEEEFGVTAAAPVAVAGG AAAGGAAEEQSEFDLILAGAGSQKIKVIKVVREITGLGLKEAKELVDNTPKPLKEGIA KEEAEELKAKLEEVGASVEVK*" gene 120607..120978 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" downshifts 120894 /Source="Nicolas_upshifts" /id="D44" /incds=1 /nref=5 /ntot=149 /MaxReadThrough="8.89506" /MaxDrop="4.0945" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2464 /isTUend="FALSE" downshifts 120967 /Source="Nicolas_upshifts" /id="D45" /incds=0 /nref=25 /ntot=157 /MaxReadThrough="7.44654" /MaxDrop="4.0033" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2537 /isTUend="FALSE" CDS 121068..121673 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" /EC_number="2.1.1.174" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17010380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2G1835 methyltransferase" /protein_id="NP_387987.1" /db_xref="EnsemblGenomes-Gn:BSU01060" /db_xref="EnsemblGenomes-Tr:CAB11882" /db_xref="GOA:P37872" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10727" /db_xref="UniProtKB/Swiss-Prot:P37872" /translation="MSEHYYSEKPSVKSNKQTWSFRLRNKDFTFTSDSGVFSKKEVDF GSRLLIDSFEEPEVEGGILDVGCGYGPIGLSLASDFKDRTIHMIDVNERAVELSNENA EQNGITNVKIYQSDLFSNVDSAQTFASILTNPPIRAGKKVVHAIFEKSAEHLKASGEL WIVIQKKQGAPSAIEKLEELFDEVSVVQKKKGYYIIKAKKV*" gene 121068..121673 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" promotor_-35 121668..121672 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 121686..121918 /Source="Nicolas_S_feature" /locus_tag="new_121686_121918" /HighExp="G180, G150, H2O2, G135, Cold, T-5.40H, LoTm, T-3.40H, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S51" upshifts 121686 /Source="Nicolas_upshifts" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" promotor_-10 121688..121707 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 121919..125500 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10049799, 10744988, 12455702, 12682299, 15060052, 28163698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10049799, 10744988, 12455702, 12682299, 15060052, 28163698; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta subunit)" /protein_id="NP_387988.2" /db_xref="EnsemblGenomes-Gn:BSU01070" /db_xref="EnsemblGenomes-Tr:CAB11883" /db_xref="GOA:P37870" /db_xref="InterPro:IPR007120" /db_xref="InterPro:IPR007121" /db_xref="InterPro:IPR007641" /db_xref="InterPro:IPR007642" /db_xref="InterPro:IPR007644" /db_xref="InterPro:IPR007645" /db_xref="InterPro:IPR010243" /db_xref="InterPro:IPR015712" /db_xref="InterPro:IPR019462" /db_xref="PDB:2LY7" /db_xref="SubtiList:BG10728" /db_xref="UniProtKB/Swiss-Prot:P37870" /translation="MTGQLVQYGRHRQRRSYARISEVLELPNLIEIQTSSYQWFLDEG LREMFQDISPIEDFTGNLSLEFIDYSLGEPKYPVEESKERDVTYSAPLRVKVRLINKE TGEVKDQDVFMGDFPIMTDTGTFIINGAERVIVSQLVRSPSVYFSGKVDKNGKKGFTA TVIPNRGAWLEYETDAKDVVYVRIDRTRKLPVTVLLRALGFGSDQEILDLIGENEYLR NTLDKDNTENSDKALLEIYERLRPGEPPTVENAKSLLDSRFFDPKRYDLANVGRYKIN KKLHIKNRLFNQRLAETLVDPETGEILAEKGQILDRRTLDKVLPYLENGIGFRKLYPN GGVVEDEVTLQSIKIFAPTDQEGEQVINVIGNAYIEEEIKNITPADIISSISYFFNLL HGVGDTDDIDHLGNRRLRSVGELLQNQFRIGLSRMERVVRERMSIQDTNTITPQQLIN IRPVIASIKEFFGSSQLSQFMDQTNPLAELTHKRRLSALGPGGLTRERAGMEVRDVHY SHYGRMCPIETPEGPNIGLINSLSSYAKVNRFGFIETPYRRVDPETGKVTGRIDYLTA DEEDNYVVAQANARLDDEGAFIDDSIVARFRGENTVVSRNRVDYMDVSPKQVVSAATA CIPFLENDDSNRALMGANMQRQAVPLMQPEAPFVGTGMEYVSGKDSGAAVICKHPGIV ERVEAKNVWVRRYEEVDGQKVKGNLDKYSLLKFVRSNQGTCYNQRPIVSVGDEVVKGE ILADGPSMELGELALGRNVMVGFMTWDGYNYEDAIIMSERLVKDDVYTSIHIEEYESE ARDTKLGPEEITRDIPNVGEDALRNLDDRGIIRIGAEVKDGDLLVGKVTPKGVTELTA EERLLHAIFGEKAREVRDTSLRVPHGGGGIIHDVKVFNREDGDELPPGVNQLVRVYIV QKRKISEGDKMAGRHGNKGVISKILPEEDMPYLPDGTPIDIMLNPLGVPSRMNIGQVL ELHMGMAARYLGIHIASPVFDGAREEDVWETLEEAGMSRDAKTVLYDGRTGEPFDNRV SVGIMYMIKLAHMVDDKLHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGA AYTLQEILTVKSDDVVGRVKTYEAIVKGDNVPEPGVPESFKVLIKELQSLGMDVKILS GDEEEIEMRDLEDEEDAKQADGLALSGDEEPEETASADVERDVVTKE*" gene 121919..125500 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" promotor_-10 complement(123504..123523) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(123507) /Source="Nicolas_upshifts" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(123537..123546) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(124375..124379) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(124380) /Source="Nicolas_upshifts" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(124394..124400) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 125562..129161 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta' subunit)" /protein_id="NP_387989.2" /db_xref="EnsemblGenomes-Gn:BSU01080" /db_xref="EnsemblGenomes-Tr:CAB11884" /db_xref="GOA:P37871" /db_xref="InterPro:IPR000722" /db_xref="InterPro:IPR006592" /db_xref="InterPro:IPR007066" /db_xref="InterPro:IPR007080" /db_xref="InterPro:IPR007081" /db_xref="InterPro:IPR007083" /db_xref="InterPro:IPR012754" /db_xref="SubtiList:BG10729" /db_xref="UniProtKB/Swiss-Prot:P37871" /translation="MLDVNNFEYMNIGLASPDKIRSWSFGEVKKPETINYRTLKPEKD GLFCERIFGPTKDWECHCGKYKRVRYKGVVCDRCGVEVTRAKVRRERMGHIELAAPVS HIWYFKGIPSRMGLVLDMSPRALEEVIYFASYVVTDPANTPLEKKQLLSEKEYRAYLD KYGNKFQASMGAEAIHKLLQDIDLVKEVDMLKEELKTSQGQRRTRAIKRLEVLEAFRN SGNKPSWMILDVLPVIPPELRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLLDLGA PSIIVQNEKRMLQEAVDALIDNGRRGRPVTGPGNRPLKSLSHMLKGKQGRFRQNLLGK RVDYSGRSVIVVGPHLKMYQCGLPKEMALELFKPFVMKELVEKGLAHNIKSAKRKIER VQPEVWDVLESVIKEHPVLLNRAPTLHRLGIQAFEPTLVEGRAIRLHPLVCTAYNADF DGDQMAVHVPLSAEAQAEARILMLAAQNILNPKDGKPVVTPSQDMVLGNYYLTLERAG AVGEGMVFKNTDEALLAYQNGYVHLHTRVAVAANSLKNVTFTEEQRSKLLITTVGKLV FNEILPESFPYMNEPTKSNIEEKTPDRFFLEKGADVKAVIAQQPINAPFKKGILGKII AEIFKRFHITETSKMLDRMKNLGFKYSTKAGITVGVSDIVVLDDKQEILEEAQSKVDN VMKQFRRGLITEEERYERVISIWSAAKDVIQGKLMKSLDELNPIYMMSDSGARGNASN FTQLAGMRGLMANPAGRIIELPIKSSFREGLTVLEYFISTHGARKGLADTALKTADSG YLTRRLVDVAQDVIIRETDCGTDRGILAKPLKEGTETIERLEERLIGRFARKQVKHPE TGEVLVNENELIDEDKALEIVEAGIEEVWIRSAFTCNTPHGVCKRCYGRNLATGSDVE VGEAVGIIAAQSIGEPGTQLTMRTFHTGGVAGDDITQGLPRIQELFEARNPKGQATIT EIDGTVVEINEVRDKQQEIVVQGAVETRSYTAPYNSRLKVAEGDKITRGQVLTEGSID PKELLKVTDLTTVQEYLLHEVQKVYRMQGVEIGDKHVEVMVRQMLRKVRVIDAGDTDV LPGTLLDIHQFTEANKKVLLEGNRPATGRPVLLGITKASLETDSFLSAASFQETTRVL TDAAIKGKRDELLGLKENVIIGKLVPAGTGMMKYRKVKPVSNVQPTDDMVPVE*" gene 125562..129161 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" downshifts complement(128626) /Source="Nicolas_upshifts" /id="D46" /incds=1 /nref=1 /ntot=76 /MaxReadThrough="3.40002" /MaxDrop="2.38911" /score="-2.05539956" /energy="-7.5" /TU="U93" /idTUdmin="U93" /TUdmin="-132" /isTUend="FALSE" upshifts complement(128780) /Source="Nicolas_upshifts" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(128798..128799) /Source="Nicolas_upshift_promotors" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(129110) /Source="Nicolas_upshifts" /id="D47" /incds=0 /nref=98 /ntot=210 /MaxReadThrough="1.61828" /MaxDrop="4.90549" /score="-2.05539956" /energy="-7.5" /TU="NA" /idTUdmin="U95" /TUdmin=0 /isTUend="TRUE" S_feature 129162..129283 /Source="Nicolas_S_feature" /locus_tag="new_129162_129283" /HighExp="LoTm, HiOs, S3, SMMPr, Heat, S1, BC, Glu, S4, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S52" promotor_-35 129265..129272 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" upshifts 129285 /Source="Nicolas_upshifts" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" promotor_-10 129286..129305 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" misc_feature complement(129303..129307) /Source="Nicolas_upshift_promotors" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(129306) /Source="Nicolas_upshifts" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 129340..129588 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein; alternative ribosomal protein L7A" /protein_id="NP_387990.1" /db_xref="EnsemblGenomes-Gn:BSU01090" /db_xref="EnsemblGenomes-Tr:CAB11885" /db_xref="GOA:P46350" /db_xref="InterPro:IPR000948" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR023460" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7E" /db_xref="PDB:4LCK" /db_xref="PDB:4TZP" /db_xref="PDB:4TZV" /db_xref="PDB:4TZW" /db_xref="PDB:4TZZ" /db_xref="SubtiList:BG11365" /db_xref="UniProtKB/Swiss-Prot:P46350" /translation="MSYDKVSQAKSIIIGTKQTVKALKRGSVKEVVVAKDADPILTSS VVSLAEDQGISVSMVESMKKLGKACGIEVGAAAVAIIL*" gene 129340..129588 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" S_feature 129589..129701 /Source="Nicolas_S_feature" /locus_tag="new_129589_129701" /HighExp="T-3.40H, M/G, T-1.40H, T-5.40H, Salt, Mal, T-0.40H, G/S, M9-exp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S53" CDS 129702..130118 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11489846, 12682299, 16484214, 18252828, 19383706, 20007320" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489846, 12682299, 16484214, 18252828, 19383706, 20007320; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S12 (BS12)" /protein_id="NP_387991.2" /db_xref="EnsemblGenomes-Gn:BSU01100" /db_xref="EnsemblGenomes-Tr:CAB11886" /db_xref="GOA:P21472" /db_xref="InterPro:IPR005679" /db_xref="InterPro:IPR006032" /db_xref="InterPro:IPR012340" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19009" /db_xref="UniProtKB/Swiss-Prot:P21472" /translation="MPTINQLIRKGRVSKVENSKSPALNKGYNSFKKEHTNVSSPQKR GVCTRVGTMTPKKPNSALRKYARVRLTNGIEVTAYIPGIGHNLQEHSVVLIRGGRVKD LPGVRYHIVRGALDTAGVENRAQGRSKYGTKKPKAK*" gene 129702..130118 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" CDS 130160..130630 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 19653700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 19653700; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S7 (BS7)" /protein_id="NP_387992.2" /db_xref="EnsemblGenomes-Gn:BSU01110" /db_xref="EnsemblGenomes-Tr:CAB11887" /db_xref="GOA:P21469" /db_xref="InterPro:IPR000235" /db_xref="InterPro:IPR005717" /db_xref="InterPro:IPR020606" /db_xref="InterPro:IPR023798" /db_xref="InterPro:IPR036823" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19006" /db_xref="UniProtKB/Swiss-Prot:P21469" /translation="MPRKGPVAKRDVLPDPIYNSKLVSRLINKMMIDGKKGKSQTILY KSFDIIKERTGNDAMEVFEQALKNIMPVLEVKARRVGGANYQVPVEVRPERRTTLGLR WLVNYARLRGEKTMEERLANEILDAANNTGAAVKKREDTHKMAEANKAFAHYRW*" gene 130160..130630 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" CDS 130684..132762 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:815236, 815243, 1556067, 4629789, 19366171, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 815236, 815243, 1556067, 4629789, 19366171, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="elongation factor G" /protein_id="NP_387993.2" /db_xref="EnsemblGenomes-Gn:BSU01120" /db_xref="EnsemblGenomes-Tr:CAB11888" /db_xref="GOA:P80868" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004540" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005517" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009022" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035649" /db_xref="PDB:5VH6" /db_xref="SubtiList:BG11939" /db_xref="UniProtKB/Swiss-Prot:P80868" /translation="MAREFSLEKTRNIGIMAHIDAGKTTTTERILFYTGRIHKIGETH EGASQMDWMEQEQERGITITSAATTAQWKGYRVNIIDTPGHVDFTVEVERSLRVLDGA VAVLDAQSGVEPQTETVWRQATTYGVPRIVFVNKMDKIGADFLYSVGTLRDRLQANAH AIQLPIGAEDNFEGIIDLVENVAYFYEDDLGTRSDAKEIPEEYKEQAEELRNSLIEAV CELDEELMDKYLEGEEITIDELKAGIRKGTLNVEFYPVLVGSAFKNKGVQLVLDAVLD YLPAPTDVAAIKGTRPDTNEEIERHSSDEEPFSALAFKVMTDPYVGKLTFFRVYSGTL DSGSYVKNSTKGKRERVGRILQMHANSREEISTVYAGDIAAAVGLKDTTTGDTLCDEK DLVILESMEFPEPVIDVAIEPKSKADQDKMGIALAKLAEEDPTFRTQTNPETGQTIIS GMGELHLDIIVDRMKREFKVEANVGAPQVAYRETFRTGAKVEGKFVRQSGGRGQFGHV WIEFEPNEEGAGFEFENAIVGGVVPREYIPAVQAGLEDALENGVLAGFPLIDIKAKLF DGSYHDVDSNEMAFKVAASMALKNAVSKCNPVLLEPIMKVEVVIPEEYMGDIMGDITS RRGRVEGMEARGNAQVVRAMVPLAEMFGYATALRSNTQGRGTFTMHMDHYEEVPKSVA EEIIKKNKGE*" gene 130684..132762 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" S_feature 132763..132881 /Source="Nicolas_S_feature" /locus_tag="new_132763_132881" /HighExp="T-5.40H, T-4.40H, UNK1, SMM, HiTm, T-3.40H, T-2.40H, SMMPr, MG 90, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S54" CDS 132882..134072 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10774755, 12682299, 7706132, 20133608, 22938038, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10774755, 12682299, 7706132, 20133608, 22938038, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="elongation factor Tu" /protein_id="NP_387994.1" /db_xref="EnsemblGenomes-Gn:BSU01130" /db_xref="EnsemblGenomes-Tr:CAB11889" /db_xref="GOA:P33166" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004160" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004541" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR033720" /db_xref="SubtiList:BG11056" /db_xref="UniProtKB/Swiss-Prot:P33166" /translation="MAKEKFDRSKSHANIGTIGHVDHGKTTLTAAITTVLHKKSGKGT AMAYDQIDGAPEERERGITISTAHVEYETETRHYAHVDCPGHADYVKNMITGAAQMDG AILVVSAADGPMPQTREHILLSKNVGVPYIVVFLNKCDMVDDEELLELVEMEVRDLLS EYDFPGDDVPVVKGSALKALEGDAEWEAKIFELMDAVDEYIPTPERDTEKPFMMPVED VFSITGRGTVATGRVERGQVKVGDEVEIIGLQEENKKTTVTGVEMFRKLLDYAEAGDN IGALLRGVSREEIQRGQVLAKPGTITPHSKFKAEVYVLSKEEGGRHTPFFSNYRPQFY FRTTDVTGIIHLPEGVEMVMPGDNTEMNVELISTIAIEEGTRFSIREGGRTVGSGVVS TITE*" gene 132882..134072 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" downshifts 134067 /Source="Nicolas_upshifts" /id="D48" /incds=0 /nref=258 /ntot=269 /MaxReadThrough="4.84568" /MaxDrop="8.56168" /score="39.3984056" /energy="-12.9" /TU="U88,U90,U94" /idTUdmin="U88" /TUdmin="-1081" /isTUend="FALSE" misc_feature complement(134098..134101) /Source="Nicolas_upshift_promotors" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(134102) /Source="Nicolas_upshifts" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 134128..134147 /Source="Nicolas_upshift_promotors" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 134136 /Source="Nicolas_upshifts" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" CDS 134171..135127 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" /EC_number="3.4.11.5" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proline iminopeptidase" /protein_id="NP_387995.2" /db_xref="EnsemblGenomes-Gn:BSU01140" /db_xref="EnsemblGenomes-Tr:CAB11890" /db_xref="GOA:P70981" /db_xref="InterPro:IPR002410" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11988" /db_xref="UniProtKB/Swiss-Prot:P70981" /translation="MIPEKKSIAIMKELSIGNTKQMLMINGVDVKNPLLLFLHGGPGT PQIGYVRHYQKELEQYFTVVHWDQRGSGLSYSKRISHHSMTINHFIKDTIQVTQWLLA HFSKSKLYLAGHSWGSILALHVLQQRPDLFYTYYGISQVVNPQDEESTAYQHIREISE SKKASILSFLTRFIGAPPWKQDIQHLIYRFCVELTRGGFTHRHRQSLAVLFQMLTGNE YGVRNMHSFLNGLRFSKKHLTDELYRFNAFTSVPSIKVPCVFISGKHDLIVPAEISKQ YYQELEAPEKRWFQFENSAHTPHIEEPSLFANTLSRHARHHL*" gene 134171..135127 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" promotor_-35 135134..135141 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 135155..135174 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 135170..135363 /Source="Nicolas_S_feature" /locus_tag="new_135170_135363" /HighExp="T-1.40H, T-2.40H, T-1.10H, SMM, T-3.40H, T-4.40H, BI, BMM, H2O2, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S55" upshifts 135170 /Source="Nicolas_upshifts" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" CDS 135364..135672 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 27964882" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 27964882; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S10 (BS13); transcription antitermination factor" /protein_id="NP_387996.1" /db_xref="EnsemblGenomes-Gn:BSU01150" /db_xref="EnsemblGenomes-Tr:CAB11891" /db_xref="GOA:P21471" /db_xref="InterPro:IPR001848" /db_xref="InterPro:IPR018268" /db_xref="InterPro:IPR027486" /db_xref="InterPro:IPR036838" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19008" /db_xref="UniProtKB/Swiss-Prot:P21471" /translation="MAKQKIRIRLKAYDHRILDQSAEKIVETAKRSGASVSGPIPLPT EKSVYTILRAVHKYKDSREQFEMRTHKRLIDIVNPTPQTVDALMRLDLPSGVDIEIKL *" gene 135364..135672 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" CDS 135712..136341 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 19154332, 23759864" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 19154332, 23759864; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L3 (BL3)" /protein_id="NP_387997.1" /db_xref="EnsemblGenomes-Gn:BSU01160" /db_xref="EnsemblGenomes-Tr:CAB11892" /db_xref="GOA:P42920" /db_xref="InterPro:IPR000597" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR019926" /db_xref="InterPro:IPR019927" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11218" /db_xref="UniProtKB/Swiss-Prot:P42920" /translation="MTKGILGRKIGMTQVFAENGDLIPVTVIEAAPNVVLQKKTAEND GYEAIQLGFDDKREKLSNKPEKGHVAKAETAPKRFVKELRGVEMDAYEVGQEVKVEIF SAGEIVDVTGVSKGKGFQGAIKRHGQSRGPMSHGSRYHRRPGSMGPVDPNRVFKGKLL PGRMGGEQITVQNLEIVKVDAERNLLLIKGNVPGAKKSLITVKSAVKSK*" gene 135712..136341 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" CDS 136369..136992 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10898684, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L4" /protein_id="NP_387998.1" /db_xref="EnsemblGenomes-Gn:BSU01170" /db_xref="EnsemblGenomes-Tr:CAB11893" /db_xref="GOA:P42921" /db_xref="InterPro:IPR002136" /db_xref="InterPro:IPR013005" /db_xref="InterPro:IPR023574" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11219" /db_xref="UniProtKB/Swiss-Prot:P42921" /translation="MPKVALYNQNGSTAGDIELNASVFGIEPNESVVFDAILMQRASL RQGTHKVKNRSEVRGGGRKPWRQKGTGRARQGSIRSPQWRGGGVVFGPTPRSYSYKLP KKVRRLAIKSVLSSKVIDNNIIVLEDLTLDTAKTKEMAAILKGLSVEKKALIVTADAN EAVALSARNIPGVTVVEANGINVLDVVNHEKLLITKAAVEKVEEVLA*" gene 136369..136992 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" CDS 136992..137279 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L23" /protein_id="NP_387999.2" /db_xref="EnsemblGenomes-Gn:BSU01180" /db_xref="EnsemblGenomes-Tr:CAB11894" /db_xref="GOA:P42924" /db_xref="InterPro:IPR001014" /db_xref="InterPro:IPR012678" /db_xref="InterPro:IPR013025" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11221" /db_xref="UniProtKB/Swiss-Prot:P42924" /translation="MKDPRDVLKRPVITERSADLMTEKKYTFEVDVRANKTEVKDAVE SIFGVKVDKVNIMNYKGKSKRVGRYTGMTSRRRKAIVKLTADSKEIEIFEA*" gene 136992..137279 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" CDS 137311..138144 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23249812, 24637032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23249812, 24637032; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L2 (BL2)" /protein_id="NP_388000.2" /db_xref="EnsemblGenomes-Gn:BSU01190" /db_xref="EnsemblGenomes-Tr:CAB11895" /db_xref="GOA:P42919" /db_xref="InterPro:IPR002171" /db_xref="InterPro:IPR005880" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR014726" /db_xref="InterPro:IPR022666" /db_xref="InterPro:IPR022669" /db_xref="InterPro:IPR022671" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11217" /db_xref="UniProtKB/Swiss-Prot:P42919" /translation="MAIKKYKPTSNGRRGMTTSDFAEITTDKPEKSLLAPLHKKGGRN NQGKLTVRHQGGGHKRQYRVIDFKRDKDGIPGRVATVEYDPNRSANIALINYADGEKR YILAPKGIQVGTEIMSGPEADIKVGNALPLINIPVGTVVHNIELKPGKGGQLVRSAGT SAQVLGKEGKYVLVRLNSGEVRMILSACRASIGQVGNEQHELINIGKAGRSRWKGIRP TVRGSVMNPNDHPHGGGEGRAPIGRKSPMSPWGKPTLGFKTRKKKNKSDKFIVRRRKN K*" gene 137311..138144 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" downshifts complement(137447) /Source="Nicolas_upshifts" /id="D49" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="3.39972" /MaxDrop="4.09052" /score="-4.16840603" /energy="-12.8" /TU="NA" /idTUdmin="U99" /TUdmin=1342 /isTUend="FALSE" CDS 138202..138480 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S19 (BS19)" /protein_id="NP_388001.1" /db_xref="EnsemblGenomes-Gn:BSU01200" /db_xref="EnsemblGenomes-Tr:CAB11896" /db_xref="GOA:P21476" /db_xref="InterPro:IPR002222" /db_xref="InterPro:IPR005732" /db_xref="InterPro:IPR020934" /db_xref="InterPro:IPR023575" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19011" /db_xref="UniProtKB/Swiss-Prot:P21476" /translation="MARSLKKGPFVDGHLMTKIEKLNETDKKQVVKTWSRRSTIFPQF IGHTIAVYDGRKHVPVFISEDMVGHKLGEFAPTRTYKGHASDDKKTRR*" gene 138202..138480 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" CDS 138497..138838 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7928988, 12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7928988, 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L22 (BL17)" /protein_id="NP_388002.1" /db_xref="EnsemblGenomes-Gn:BSU01210" /db_xref="EnsemblGenomes-Tr:CAB11897" /db_xref="GOA:P42060" /db_xref="InterPro:IPR001063" /db_xref="InterPro:IPR005727" /db_xref="InterPro:IPR018260" /db_xref="InterPro:IPR036394" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11078" /db_xref="UniProtKB/Swiss-Prot:P42060" /translation="MQAKAVARTVRIAPRKARLVMDLIRGKQVGEAVSILNLTPRAAS PIIEKVLKSAIANAEHNYEMDANNLVISQAFVDEGPTLKRFRPRAMGRASQINKRTSH ITIVVSEKKEG*" gene 138497..138838 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" CDS 138842..139498 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S3 (BS3)" /protein_id="NP_388003.2" /db_xref="EnsemblGenomes-Gn:BSU01220" /db_xref="EnsemblGenomes-Tr:CAB11898" /db_xref="GOA:P21465" /db_xref="InterPro:IPR001351" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR005704" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR018280" /db_xref="InterPro:IPR036419" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19005" /db_xref="UniProtKB/Swiss-Prot:P21465" /translation="MGQKVNPVGLRIGVIRDWESKWYAGKDYADFLHEDLKIREYISK RLSDASVSKVEIERAANRVNITIHTAKPGMVIGKGGSEVEALRKALNSLTGKRVHINI LEIKRADLDAQLVADNIARQLENRVSFRRAQKQQIQRTMRAGAQGVKTMVSGRLGGAD IARSEYYSEGTVPLHTLRADIDYATSEADTTYGKLGVKVWIYRGEVLPTKKKNEEGGK *" gene 138842..139498 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" downshifts complement(138855) /Source="Nicolas_upshifts" /id="D50" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="3.68388" /MaxDrop="2.1922" /score="-4.16840603" /energy="-12.8" /TU="U99" /idTUdmin="U99" /TUdmin="-66" /isTUend="FALSE" promotor_-10 complement(138936..138940) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(138943) /Source="Nicolas_upshifts" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(138957..138959) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 139500..139934 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L16" /protein_id="NP_388004.1" /db_xref="EnsemblGenomes-Gn:BSU01230" /db_xref="EnsemblGenomes-Tr:CAB11899" /db_xref="GOA:P14577" /db_xref="InterPro:IPR000114" /db_xref="InterPro:IPR016180" /db_xref="InterPro:IPR020798" /db_xref="InterPro:IPR036920" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10755" /db_xref="UniProtKB/Swiss-Prot:P14577" /translation="MLLPKRVKYRREHRGKMRGRAKGGTEVHFGEFGIQALEASWITN RQIEAARIAMTRYMKRGGKVWIKIFPSKPYTAKPLEVRMGSGKGAPEGWVAVVKPGKV LFEISGVSEEVAREALRLASHKLPIKTKFVKREEIGGESNES*" gene 139500..139934 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" CDS 139924..140124 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L29" /protein_id="NP_388005.1" /db_xref="EnsemblGenomes-Gn:BSU01240" /db_xref="EnsemblGenomes-Tr:CAB11900" /db_xref="GOA:P12873" /db_xref="InterPro:IPR001854" /db_xref="InterPro:IPR018254" /db_xref="InterPro:IPR036049" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10756" /db_xref="UniProtKB/Swiss-Prot:P12873" /translation="MKANEIRDLTTAEIEQKVKSLKEELFNLRFQLATGQLENTARIR EVRKAIARMKTVIREREIAANK*" gene 139924..140124 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" CDS 140147..140410 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S17 (BS16)" /protein_id="NP_388006.1" /db_xref="EnsemblGenomes-Gn:BSU01250" /db_xref="EnsemblGenomes-Tr:CAB11901" /db_xref="GOA:P12874" /db_xref="InterPro:IPR000266" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019979" /db_xref="InterPro:IPR019984" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10757" /db_xref="UniProtKB/Swiss-Prot:P12874" /translation="MSERNQRKVYQGRVVSDKMDKTITVVVETYKKHTLYGKRVKYSK KFKAHDENNQAKIGDIVKIMETRPLSATKRFRLVEVVEEAVII*" gene 140147..140410 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" CDS 140451..140819 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 8805509, 12682299, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 8805509, 12682299, 22829778; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L14" /protein_id="NP_388007.1" /db_xref="EnsemblGenomes-Gn:BSU01260" /db_xref="EnsemblGenomes-Tr:CAB11902" /db_xref="GOA:P12875" /db_xref="InterPro:IPR000218" /db_xref="InterPro:IPR005745" /db_xref="InterPro:IPR019972" /db_xref="InterPro:IPR036853" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10758" /db_xref="UniProtKB/Swiss-Prot:P12875" /translation="MIQQETRLKVADNSGAREVLTIKVLGGSGRKTANIGDVIVCTVK QATPGGVVKKGEVVKAVIVRTKSGARRSDGSYISFDENACVIIRDDKSPRGTRIFGPV ARELRENNFMKIVSLAPEVI*" gene 140451..140819 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" CDS 140857..141168 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11278078, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11278078, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L24 (BL23)" /protein_id="NP_388008.1" /db_xref="EnsemblGenomes-Gn:BSU01270" /db_xref="EnsemblGenomes-Tr:CAB11903" /db_xref="GOA:P0CI78" /db_xref="InterPro:IPR003256" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR005825" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10759" /db_xref="UniProtKB/Swiss-Prot:P0CI78" /translation="MHVKKGDKVMVISGKDKGKQGTILAAFPKKDRVLVEGVNMVKKH SKPTQANPQGGISNQEAPIHVSNVMPLDPKTGEVTRVGYKVEDGKKVRVAKKSGQVLD K*" gene 140857..141168 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" CDS 141195..141734 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L5 (BL6)" /protein_id="NP_388009.1" /db_xref="EnsemblGenomes-Gn:BSU01280" /db_xref="EnsemblGenomes-Tr:CAB11904" /db_xref="GOA:P12877" /db_xref="InterPro:IPR002132" /db_xref="InterPro:IPR020929" /db_xref="InterPro:IPR020930" /db_xref="InterPro:IPR022803" /db_xref="InterPro:IPR031309" /db_xref="InterPro:IPR031310" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10760" /db_xref="UniProtKB/Swiss-Prot:P12877" /translation="MNRLKEKYNKEIAPALMTKFNYDSVMQVPKIEKIVINMGVGDAV QNAKAIDSAVEELTFIAGQKPVVTRAKKSIAGFRLREGMPIGAKVTLRGERMYDFLDK LISVSLPRVRDFRGVSKKSFDGRGNYTLGIKEQLIFPEIDYDKVTKVRGMDIVIVTTA NTDEEARELLTQVGMPFQK*" gene 141195..141734 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" CDS 141757..141942 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17163968, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17163968, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S14" /protein_id="NP_388010.1" /db_xref="EnsemblGenomes-Gn:BSU01290" /db_xref="EnsemblGenomes-Tr:CAB11905" /db_xref="GOA:P12878" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023053" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10761" /db_xref="UniProtKB/Swiss-Prot:P12878" /translation="MAKKSMIAKQQRTPKFKVQEYTRCERCGRPHSVIRKFKLCRICF RELAYKGQIPGVKKASW*" gene 141757..141942 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" CDS 141974..142372 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S8 (BS8)" /protein_id="NP_388011.2" /db_xref="EnsemblGenomes-Gn:BSU01300" /db_xref="EnsemblGenomes-Tr:CAB11906" /db_xref="GOA:P12879" /db_xref="InterPro:IPR000630" /db_xref="InterPro:IPR035987" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10762" /db_xref="UniProtKB/Swiss-Prot:P12879" /translation="MVMTDPIADMLTRIRNANMVRHEKLEIPASKLKREIAEILKREG FIRDVEFVEDSKQGIIRVFLKYGQNNERVITGLKRISKPGLRVYAKSNEVPRVLNGLG IAIISTSQGVLTDKEARAKQAGGEVLAYVW*" gene 141974..142372 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" downshifts complement(142375) /Source="Nicolas_upshifts" /id="D51" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="2.68318" /MaxDrop="2.55712" /score="5.40276403" /energy="-15.9" /TU="NA" /idTUdmin="U99" /TUdmin="-3586" /isTUend="FALSE" CDS 142402..142941 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 25330043; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L6 (BL8)" /protein_id="NP_388012.1" /db_xref="EnsemblGenomes-Gn:BSU01310" /db_xref="EnsemblGenomes-Tr:CAB11907" /db_xref="GOA:P46898" /db_xref="InterPro:IPR000702" /db_xref="InterPro:IPR002358" /db_xref="InterPro:IPR019906" /db_xref="InterPro:IPR020040" /db_xref="InterPro:IPR036789" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11408" /db_xref="UniProtKB/Swiss-Prot:P46898" /translation="MSRVGKKLLEIPSDVTVTLNDNNTVAVKGPKGELTRTFHPDMEI KVEDNVLTVARPSDQKEHRALHGTTRSLLGNMVEGVSKGFERGLELVGVGYRASKSGN KLVLNVGYSHPVEIVPEEGIEIEVPSQTKVVVKGTDKERVGAIAANIRAVRSPEPYKG KGIRYEGEVVRRKEGKSAK*" gene 142402..142941 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" CDS 142974..143336 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L18" /protein_id="NP_388013.2" /db_xref="EnsemblGenomes-Gn:BSU01320" /db_xref="EnsemblGenomes-Tr:CAB11908" /db_xref="GOA:P46899" /db_xref="InterPro:IPR004389" /db_xref="InterPro:IPR005484" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11409" /db_xref="UniProtKB/Swiss-Prot:P46899" /translation="MITKTSKNAARLKRHARVRAKLSGTAERPRLNVFRSNKHIYAQI IDDVNGVTLASASTLDKDLNVESTGDTSAATKVGELVAKRAAEKGISDVVFDRGGYLY HGRVKALADAAREAGLKF*" gene 142974..143336 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" CDS 143361..143861 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6211592, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6211592, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S5" /protein_id="NP_388014.1" /db_xref="EnsemblGenomes-Gn:BSU01330" /db_xref="EnsemblGenomes-Tr:CAB11909" /db_xref="GOA:P21467" /db_xref="InterPro:IPR000851" /db_xref="InterPro:IPR005324" /db_xref="InterPro:IPR005712" /db_xref="InterPro:IPR013810" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018192" /db_xref="InterPro:IPR020568" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10442" /db_xref="UniProtKB/Swiss-Prot:P21467" /translation="MRRIDPSKLELEERLVTVNRVAKVVKGGRRFRFAALVVVGDKNG HVGFGTGKAQEVPEAIRKAVEDAKKNLIEVPMVGTTIPHEIIGRFGAGNILLKPASEG TGVIAGGPVRAVLELAGVADILSKSLGSNTPINMIRATLQGLSELKRAEDVAKLRGKS VEELLG*" gene 143361..143861 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" CDS 143875..144054 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L30 (BL27)" /protein_id="NP_388015.1" /db_xref="EnsemblGenomes-Gn:BSU01340" /db_xref="EnsemblGenomes-Tr:CAB11910" /db_xref="GOA:P19947" /db_xref="InterPro:IPR005996" /db_xref="InterPro:IPR016082" /db_xref="InterPro:IPR018038" /db_xref="InterPro:IPR036919" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10443" /db_xref="UniProtKB/Swiss-Prot:P19947" /translation="MAKLEITLKRSVIGRPEDQRVTVRTLGLKKTNQTVVHEDNAAIR GMINKVSHLVSVKEQ*" gene 143875..144054 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" CDS 144085..144525 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15855514, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15855514, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L15" /protein_id="NP_388016.1" /db_xref="EnsemblGenomes-Gn:BSU01350" /db_xref="EnsemblGenomes-Tr:CAB11911" /db_xref="GOA:P19946" /db_xref="InterPro:IPR001196" /db_xref="InterPro:IPR005749" /db_xref="InterPro:IPR021131" /db_xref="InterPro:IPR030878" /db_xref="InterPro:IPR036227" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10444" /db_xref="UniProtKB/Swiss-Prot:P19946" /translation="MKLHELKPSEGSRKTRNRVGRGIGSGNGKTAGKGHKGQNARSGG GVRPGFEGGQMPLFQRLPKRGFTNINRKEYAVVNLDKLNGFAEGTEVTPELLLETGVI SKLNAGVKILGNGKLEKKLTVKANKFSASAKEAVEAAGGTAEVI*" gene 144085..144525 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" CDS 144527..145822 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478; Product type t: transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_388017.1" /db_xref="EnsemblGenomes-Gn:BSU01360" /db_xref="EnsemblGenomes-Tr:CAB11912" /db_xref="GOA:P16336" /db_xref="InterPro:IPR002208" /db_xref="InterPro:IPR023201" /db_xref="InterPro:IPR026593" /db_xref="InterPro:IPR030659" /db_xref="SubtiList:BG10445" /db_xref="UniProtKB/Swiss-Prot:P16336" /translation="MFKTISNFMRVSDIRNKIIFTLLMLIVFRIGAFIPVPYVNAEAL QAQSQMGVFDLLNTFGGGALYQFSIFAMGITPYITASIIIQLLQMDVVPKFTEWSKQG EVGRRKLAQFTRYFTIVLGFIQALGMSYGFNNLANGMLIEKSGVSTYLIIALVLTGGT AFLMWLGEQITSHGVGNGISIIIFAGIVSSIPKTIGQIYETQFVGSNDQLFIHIVKVA LLVIAILAVIVGVIFIQQAVRKIAIQYAKGTGRSPAGGGQSTHLPLKVNPAGVIPVIF AVAFLITPRTIASFFGTNDVTKWIQNNFDNTHPVGMAIYVALIIAFTYFYAFVQVNPE QMADNLKKQGGYIPGVRPGKMTQDRITSILYRLTFVGSIFLAVISILPIFFIQFAGLP QSAQIGGTSLLIVVGVALETMKQLESQLVKRNYRGFMKN*" gene 144527..145822 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" CDS 145877..146530 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" /EC_number="2.7.4.3" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8061005, 8288548, 9056261, 9715904, 11106368, 16452168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8061005, 8288548, 9056261, 9715904, 11106368, 16452168; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate kinase" /protein_id="NP_388018.1" /db_xref="EnsemblGenomes-Gn:BSU01370" /db_xref="EnsemblGenomes-Tr:CAB11913" /db_xref="GOA:P16304" /db_xref="InterPro:IPR000850" /db_xref="InterPro:IPR006259" /db_xref="InterPro:IPR007862" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033690" /db_xref="PDB:1P3J" /db_xref="PDB:2EU8" /db_xref="PDB:2OO7" /db_xref="PDB:2ORI" /db_xref="PDB:2OSB" /db_xref="PDB:2P3S" /db_xref="PDB:2QAJ" /db_xref="PDB:3DKV" /db_xref="PDB:3DL0" /db_xref="PDB:4MKF" /db_xref="PDB:4MKG" /db_xref="PDB:4MKH" /db_xref="PDB:4QBF" /db_xref="PDB:4QBG" /db_xref="PDB:4TYP" /db_xref="PDB:4TYQ" /db_xref="SubtiList:BG10446" /db_xref="UniProtKB/Swiss-Prot:P16304" /translation="MNLVLMGLPGAGKGTQGERIVEDYGIPHISTGDMFRAAMKEETP LGLEAKSYIDKGELVPDEVTIGIVKERLGKDDCERGFLLDGFPRTVAQAEALEEILEE YGKPIDYVINIEVDKDVLMERLTGRRICSVCGTTYHLVFNPPKTPGICDKDGGELYQR ADDNEETVSKRLEVNMKQTQPLLDFYSEKGYLANVNGQQDIQDVYADVKDLLGGLKK* " gene 145877..146530 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" CDS 146527..147273 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16207374, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase" /protein_id="NP_388019.1" /db_xref="EnsemblGenomes-Gn:BSU01380" /db_xref="EnsemblGenomes-Tr:CAB11914" /db_xref="GOA:P19994" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG10447" /db_xref="UniProtKB/Swiss-Prot:P19994" /translation="MIICKTPRELGIMREAGRIVALTHEELKKHIKPGISTKELDQIA ERFIKKQGAIPSFKGYNGFRGSICVSVNEELVHGIPGSRVLKDGDIISIDIGAKLNGY HGDSAWTYPVGNISDDDKKLLEVTEESLYKGLQEAKPGERLSNISHAIQTYVENEQFS VVREYVGHGVGQDLHEDPQIPHYGPPNKGPRLKPGMVLAIEPMVNAGSRYVKTLADNW TVVTVDGKKCAHFEHTIAITETGFDILTRV*" gene 146527..147273 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" CDS 147312..147536 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17157877; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative ribosome binding protein" /protein_id="YP_003097669.1" /db_xref="EnsemblGenomes-Gn:BSU01389" /db_xref="EnsemblGenomes-Tr:CAX52539" /db_xref="UniProtKB/Swiss-Prot:C0H3S8" /translation="MIGQKAWVNIGKTEFILLLVVGILTIINVLTADGEKRTFHSPKK KNINHLTLYDCVSPEVQNSINETGRVTNFF*" gene 147312..147536 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" CDS 147585..147803 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9868784, 20477873, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-I" /protein_id="NP_388020.1" /db_xref="EnsemblGenomes-Gn:BSU01390" /db_xref="EnsemblGenomes-Tr:CAB11915" /db_xref="GOA:P20458" /db_xref="InterPro:IPR004368" /db_xref="InterPro:IPR006196" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11043" /db_xref="UniProtKB/Swiss-Prot:P20458" /translation="MAKDDVIEVEGTIVETLPNAMFKVELENGHTVLAHVSGKIRMHF IRILPGDKVTVELSPYDLTRGRITYRYK*" gene 147585..147803 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" CDS 147837..147950 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1783905, 23002217, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1783905, 23002217, 24335279; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L36 (ribosomal protein B)" /protein_id="NP_388021.1" /db_xref="EnsemblGenomes-Gn:BSU01400" /db_xref="EnsemblGenomes-Tr:CAB11916" /db_xref="GOA:P20278" /db_xref="InterPro:IPR000473" /db_xref="InterPro:IPR035977" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11042" /db_xref="UniProtKB/Swiss-Prot:P20278" /translation="MKVRPSVKPICEKCKVIRRKGKVMVICENPKHKQKQG*" gene 147837..147950 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" CDS 147973..148338 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S13" /protein_id="NP_388022.2" /db_xref="EnsemblGenomes-Gn:BSU01410" /db_xref="EnsemblGenomes-Tr:CAB11917" /db_xref="GOA:P20282" /db_xref="InterPro:IPR001892" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR018269" /db_xref="InterPro:IPR019980" /db_xref="InterPro:IPR027437" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10730" /db_xref="UniProtKB/Swiss-Prot:P20282" /translation="MARIAGVDIPRDKRVVISLTYIFGIGRTTAQQVLKEAGVSEDTR VRDLTEEELGKIRDIIDKLKVEGDLRREVSLNIKRLIEIGSYRGIRHRRGLPVRGQNS KNNARTRKGPRRTVANKKK*" gene 147973..148338 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" CDS 148359..148754 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217780, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217780, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S11 (BS11)" /protein_id="NP_388023.1" /db_xref="EnsemblGenomes-Gn:BSU01420" /db_xref="EnsemblGenomes-Tr:CAB11918" /db_xref="GOA:P04969" /db_xref="InterPro:IPR001971" /db_xref="InterPro:IPR018102" /db_xref="InterPro:IPR019981" /db_xref="InterPro:IPR036967" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10731" /db_xref="UniProtKB/Swiss-Prot:P04969" /translation="MAAARKSNTRKRRVKKNIESGIAHIRSTFNNTIVTITDTHGNAI SWSSAGALGFRGSRKSTPFAAQMAAETAAKGSIEHGLKTLEVTVKGPGSGREAAIRAL QAAGLEVTAIRDVTPVPHNGCRPPKRRRV*" gene 148359..148754 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" S_feature 148755..148930 /Source="Nicolas_S_feature" /locus_tag="new_148755_148930" /HighExp="G135, dia5, Lbexp, S0, aero, dia0, T-4.40H, G150, Paraq, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S56" CDS 148931..149875 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1484484, 6811591, 9594570, 10972808, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1484484, 6811591, 9594570, 10972808, 12682299, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (alpha subunit)" /protein_id="NP_388024.1" /db_xref="EnsemblGenomes-Gn:BSU01430" /db_xref="EnsemblGenomes-Tr:CAB11919" /db_xref="GOA:P20429" /db_xref="InterPro:IPR011260" /db_xref="InterPro:IPR011262" /db_xref="InterPro:IPR011263" /db_xref="InterPro:IPR011773" /db_xref="InterPro:IPR036603" /db_xref="InterPro:IPR036643" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG10732" /db_xref="UniProtKB/Swiss-Prot:P20429" /translation="MIEIEKPKIETVEISDDAKFGKFVVEPLERGYGTTLGNSLRRIL LSSLPGAAVTSIQIDGVLHEFSTIEGVVEDVTTIILHIKKLALKIYSDEEKTLEIDVQ GEGTVTAADITHDSDVEILNPDLHIATLGENASFRVRLTAQRGRGYTPADANKRDDQP IGVIPIDSIYTPVSRVSYQVENTRVGQVANYDKLTLDVWTDGSTGPKEAIALGSKILT EHLNIFVGLTDEAQHAEIMVEKEEDQKEKVLEMTIEELDLSVRSYNCLKRAGINTVQE LANKTEEDMMKVRNLGRKSLEEVKAKLEELGLGLRKDD*" gene 148931..149875 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" CDS 149953..150315 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6801428, 10717392, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6801428, 10717392, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L17 (BL15)" /protein_id="NP_388025.1" /db_xref="EnsemblGenomes-Gn:BSU01440" /db_xref="EnsemblGenomes-Tr:CAB11920" /db_xref="GOA:P20277" /db_xref="InterPro:IPR000456" /db_xref="InterPro:IPR036373" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11041" /db_xref="UniProtKB/Swiss-Prot:P20277" /translation="MSYRKLGRTSAQRKAMLRDLTTDLIINERIETTETRAKELRSVV EKMITLGKRGDLHARRQAAAYIRNEVANEENNQDALQKLFSDIATRYEERQGGYTRIM KLGPRRGDGAPMAIIELV*" gene 149953..150315 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" downshifts 150317 /Source="Nicolas_upshifts" /id="D52" /incds=0 /nref=171 /ntot=259 /MaxReadThrough="7.50771" /MaxDrop="5.4374" /score="2.32634618" /energy="-10.5" /TU="U98" /idTUdmin="U98" /TUdmin="-5577" /isTUend="FALSE" S_feature 150362..150442 /Source="Nicolas_S_feature" /locus_tag="new_150362_150442" /HighExp="Cold, G180, G135, G150, H2O2, S0, C30, Oxctl, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S57" CDS 150443..151288 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388026.2" /db_xref="EnsemblGenomes-Gn:BSU01450" /db_xref="EnsemblGenomes-Tr:CAB11921" /db_xref="GOA:P40735" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030947" /db_xref="SubtiList:BG11067" /db_xref="UniProtKB/Swiss-Prot:P40735" /translation="MNQNQLISVEDIVFRYRKDAERRALDGVSLQVYEGEWLAIVGHN GSGKSTLARALNGLILPESGDIEVAGIQLTEESVWEVRKKIGMVFQNPDNQFVGTTVR DDVAFGLENNGVPREEMIERVDWAVKQVNMQDFLDQEPHHLSGGQKQRVAIAGVIAAR PDIIILDEATSMLDPIGREEVLETVRHLKEQGMATVISITHDLNEAAKADRIIVMNGG KKYAEGPPEEIFKLNKELVRIGLDLPFSFQLSQLLRENGLALEENHLTQEGLVKELWT LQSKM*" gene 150443..151288 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" CDS 151303..152133 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12110480, 21135102, 26052893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388027.1" /db_xref="EnsemblGenomes-Gn:BSU01460" /db_xref="EnsemblGenomes-Tr:CAB11922" /db_xref="GOA:P70970" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030946" /db_xref="SubtiList:BG11989" /db_xref="UniProtKB/Swiss-Prot:P70970" /translation="MKTPFERLALYDINASIKEGSYVAVIGHTGSGKSTLLQHLNGLL KPTKGQISLGSTVIQAGKKNKDLKKLRKKVGIVFQFPEHQLFEETVLKDISFGPMNFG VKKEDAEQKAREMLQLVGLSEELLDRSPFELSGGQMRRVAIAGVLAMDPEVLVLDEPT AGLDPRGRKEIMDMFYELHQRGNLTTILVTHSMEDAAAYADEMIVMHKGTIQASGSPR DLFLKGEEMAGWGLDLPETIKFQRHLEAALGVRFNEPMLTIEDAAAEIRALFQGEKTL *" gene 151303..152133 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" CDS 152130..152927 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 18931129, 21135102, 26052893; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the influx ECF transporters" /protein_id="NP_388028.2" /db_xref="EnsemblGenomes-Gn:BSU01470" /db_xref="EnsemblGenomes-Tr:CAB11923" /db_xref="GOA:P70972" /db_xref="InterPro:IPR003339" /db_xref="InterPro:IPR024919" /db_xref="SubtiList:BG11990" /db_xref="UniProtKB/Swiss-Prot:P70972" /translation="MMDSMIIGKYVPGTSLVHRLDPRTKLITIFLFVCIVFLANNVQT YALLGLFTIGVVSLTRVPFSFLMKGLKPIIWIVLFTFLLHILMTHEGPIIFQIGFFKV YEGGLVQGIFISLRFVYLILITTLLTLTTTPIEITDGMEQLLNPLKKLKLPVHELALM MSISLRFIPTLMEETDKIMKAQMARGVDFTSGPVKERVKAIVPLLVPLFVSAFKRAEE LAVAMEARGYQGGEGRTKYRKLVWTGKDTSVIVSLIVLAALLFFLRA*" gene 152130..152927 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" CDS 152937..153680 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" /EC_number="5.4.99.12" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10529181, 15353568, 17114947, 17466622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine (38-40) synthase" /protein_id="NP_388029.2" /db_xref="EnsemblGenomes-Gn:BSU01480" /db_xref="EnsemblGenomes-Tr:CAB11924" /db_xref="GOA:P70973" /db_xref="InterPro:IPR001406" /db_xref="InterPro:IPR020095" /db_xref="InterPro:IPR020097" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG11992" /db_xref="UniProtKB/Swiss-Prot:P70973" /translation="MRLKCTISYDGHLFNGYQVQPGKRTVQDELEKALAVLHKSKDRI PVVSSGRTDSGVHAAGQVIHFDTPLSIPAERWPYALNALLPDDIAVKQAEIADDGFHA RFSAVKKEYRYFVYTEKHPDVFKRHYAYHFSYRLNVQDMREAAKHLIGTHDFTSFCAA KTEVQDKVRTIYELDWTETADGLQMRITGSGFLYNMVRIIAGTLLDAGIGKISPDEVK SMLEAKDREAAGRTAPGHGLYLWNVYYDN*" gene 152937..153680 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" S_feature complement(153039..153507) /Source="Nicolas_S_feature" /locus_tag="new_153039_153507_c" /HighExp="S6, S8, S7, C30, G135, BT, S5, C90, M/G, Pyr" /AntisenseName="truA" /AntisenseCor="-0.30232258010971202" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S58" promotor_-35 153172..153177 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 153192..153209 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 153211 /Source="Nicolas_upshifts" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" promotor_-10 complement(153507..153526) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(153529) /Source="Nicolas_upshifts" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" promotor_-35 complement(153539..153548) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 153700..153706 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 153721..153740 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 153725 /Source="Nicolas_upshifts" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" misc_RNA 153737..153793 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" /product="putative L13_leader" /note="Evidence 3: Putative function from multiple computational evidences; Product type n: RNA" gene 153737..153793 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" CDS 153842..154279 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 23504016, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 23504016, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L13" /protein_id="NP_388030.2" /db_xref="EnsemblGenomes-Gn:BSU01490" /db_xref="EnsemblGenomes-Tr:CAB11925" /db_xref="GOA:P70974" /db_xref="InterPro:IPR005822" /db_xref="InterPro:IPR005823" /db_xref="InterPro:IPR023563" /db_xref="InterPro:IPR036899" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11970" /db_xref="UniProtKB/Swiss-Prot:P70974" /translation="MRTTPMANASTIERKWLVVDAAGKTLGRLSSEVAAILRGKHKPT YTPHVDTGDHVIIINAEKIELTGKKLTDKIYYRHTQHPGGLKSRTALEMRTNYPEKML ELAIKGMLPKGSLGRQMFKKLNVYRGSEHPHEAQKPEVYELRG*" gene 153842..154279 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" CDS 154300..154692 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 19653700, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S9" /protein_id="NP_388031.1" /db_xref="EnsemblGenomes-Gn:BSU01500" /db_xref="EnsemblGenomes-Tr:CAB11926" /db_xref="GOA:P21470" /db_xref="InterPro:IPR000754" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020574" /db_xref="InterPro:IPR023035" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19007" /db_xref="UniProtKB/Swiss-Prot:P21470" /translation="MAQVQYYGTGRRKSSVARVRLVPGEGRIVVNNREISEHIPSAAL IEDIKQPLTLTETAGTYDVLVNVHGGGLSGQAGAIRHGIARALLEADPEYRTTLKRAG LLTRDARMKERKKYGLKGARRAPQFSKR*" gene 154300..154692 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" downshifts 154667 /Source="Nicolas_upshifts" /id="D53" /incds=0 /nref=262 /ntot=282 /MaxReadThrough="4.65387" /MaxDrop="8.11906" /score="30.5093496" /energy="-13.3" /TU="U98,U100,U102" /idTUdmin="U98" /TUdmin="-1227" /isTUend="FALSE" promotor_-35 154809..154816 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 154830..154849 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 154838..155119 /Source="Nicolas_S_feature" /locus_tag="new_154838_155119" /HighExp="H2O2, G180, G135, Paraq, Diami, dia15, Oxctl, Cold, Heat, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.479, 1" /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S59" upshifts 154838 /Source="Nicolas_upshifts" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" misc_feature 155118..155137 /Source="Nicolas_upshift_promotors" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 155121 /Source="Nicolas_upshifts" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" CDS 155156..155923 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26582911; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388032.2" /db_xref="EnsemblGenomes-Gn:BSU01510" /db_xref="EnsemblGenomes-Tr:CAB11927" /db_xref="GOA:P70976" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11994" /db_xref="UniProtKB/Swiss-Prot:P70976" /translation="MNALVAHNSKAWDKKVETGNEWTVAVEQQVIEQAKKGNWDIRVT PMKDVPKDWFPPIKGLKVLCLASGGGQQGPVLAAAGADVTVLDNSEKQLNQDRMIAER DGLTIHTVKGSMDDLSVFNDESFDVIVHPVANVFVENVLPVWKEAYRVLKRNGILISG FVNPVVFLFDTELEQQGVLKVKHSIPYADPEDLPKHKVKKLIENNEALEFGHSLEDQI KGQIDAGFIVTGFYEDKGGFVLDQYIHTYSATRSVKV*" gene 155156..155923 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" downshifts 155914 /Source="Nicolas_upshifts" /id="D54" /incds=0 /nref=215 /ntot=251 /MaxReadThrough="2.69346" /MaxDrop="6.09641" /score="4.42269359" /energy="-10.3" /TU="NA" /idTUdmin="U100" /TUdmin="-2" /isTUend="TRUE" promotor_-35 156053..156059 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 156074..156085 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 156081 /Source="Nicolas_upshifts" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" CDS 156109..156552 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679227, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388033.1" /db_xref="EnsemblGenomes-Gn:BSU01520" /db_xref="EnsemblGenomes-Tr:CAB11928" /db_xref="GOA:P50862" /db_xref="InterPro:IPR019667" /db_xref="SubtiList:BG11503" /db_xref="UniProtKB/Swiss-Prot:P50862" /translation="MAEVLSFMDVKRQKDFELEKNLLKELSLRQIIQSVKDCLEPLFP FLHDERDIITEGCIDFAIEAYLLGGRFGIFGYYGESMQSISARSAREEEELRMEFFDY LYNWIHEQYATFDKNTVYEAARKFIKDWWTAGFVQREKQCKLRMR*" gene 156109..156552 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" promotor_-35 156552..156557 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 156573..156591 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 156574 /Source="Nicolas_upshifts" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" CDS 156612..157325 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" /EC_number="3.5.1.28" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_388034.1" /db_xref="EnsemblGenomes-Gn:BSU01530" /db_xref="EnsemblGenomes-Tr:CAB11929" /db_xref="GOA:P50864" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR014234" /db_xref="SubtiList:BG11514" /db_xref="UniProtKB/Swiss-Prot:P50864" /translation="MRKKLKWLSFLLGFIILLFLFKYQFSNNDSWKPWSLPLSGKIIY LDPGHGGPDGGAVGGKLLEKDVTLEVAFRVRDYLQEQGALVIMTRESDTDLAPEGTKG YSRRKAEDLRQRVKLINHSEAELYISIHLNAIPSQKWSGAQSFYYGKYAENEKVAKYI QDELRRNLENTTRKAKRIHGIYLMQNVTKPGALIEVGFLSNPSEATLLGKPKYQDKVA SSIYKGILRYFTEKGDPPE*" gene 156612..157325 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" upshifts 157370 /Source="Nicolas_upshifts" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" misc_feature 157373..157392 /Source="Nicolas_upshift_promotors" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 157421..158479 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11790741, 15126467, 26094643" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11790741, 15126467, 26094643; Product type r: regulator" /codon_start=1 /transl_table=11 /product="phosphorylation-dependent (Y327) transcriptionalregulator" /protein_id="NP_388035.1" /db_xref="EnsemblGenomes-Gn:BSU01540" /db_xref="EnsemblGenomes-Tr:CAB11930" /db_xref="GOA:P50863" /db_xref="InterPro:IPR000808" /db_xref="InterPro:IPR019591" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033756" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG11494" /db_xref="UniProtKB/Swiss-Prot:P50863" /translation="MIREDEVRKLVGEMREPFLQRPLGELDAVKEIKIKPEKRHISVK VALAKTGTAEQMQIQQEIVNVLKGAGAETVGLRFEELPEETVAKFRAPSAEKKTLLNM DNPPVFLAVASGKGGVGKSTVSVNLAISLARLGKKVGLIDADIYGFSVPDMMGITVRP TIEGEKLLPVERFGVKVMSMGFFVEENAPVVWRGPMLGKMLNNFFHEVEWGEVDYIVL DLPPGTGDVALDVHTMLPSCKEIIVSTPHPTAAFVAARAGSMAIKTDHEVVGVIENMA YYESAKTGEREYVFGKGGGDKLAEELNVPLLGRIPLKQPDWDKDQFAPSVYDENHPIG EIYQDIAKKIDAKMSVQV*" gene 157421..158479 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" S_feature complement(158050..158514) /Source="Nicolas_S_feature" /locus_tag="new_158050_158514_c" /HighExp="S8, S7, S6, S5, C30, S4, C90, nit, ferm, Gly" /AntisenseName="salA" /AntisenseCor="-0.104183954485248" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S60" downshifts 158465 /Source="Nicolas_upshifts" /id="D55" /incds=0 /nref=29 /ntot=155 /MaxReadThrough="5.44939" /MaxDrop="4.18382" /score="-4.46878413" /energy="-9.1" /TU="U107" /idTUdmin="U106" /TUdmin=1185 /isTUend="FALSE" S_feature 158510..159181 /Source="Nicolas_S_feature" /locus_tag="new_158510_159181" /HighExp="Lbtran, H2O2, Cold, Lbstat, dia5, M40t45, M0t90, M40t90, T0.30H, S1" /AntisenseName="gerD" /AntisenseCor="-0.24235509346425901" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S61" CDS complement(158515..159072) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17122337, 10618233, 10376819, 24530795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17122337, 10618233, 10376819, 24530795; Product type f: factor" /codon_start=1 /transl_table=11 /product="lipoprotein factor mediating clustering of germination proteins" /protein_id="NP_388036.1" /db_xref="EnsemblGenomes-Gn:BSU01550" /db_xref="EnsemblGenomes-Tr:CAB11931" /db_xref="GOA:P16450" /db_xref="SubtiList:BG10644" /db_xref="UniProtKB/Swiss-Prot:P16450" /translation="MSKAKTLLMSCFLLLSVTACAPKDQAADMDYDQTKKMVVDILKT DDGKKAIKELLNDDAMNEALVIDQDAIKGTIEKTLTSKKGEEFWKNIFEDTDFAEGFA KTLQTEHEKVIKKLMKDPDYQKMLMSVMQDPGMDKKYSQLAKSQEFRSYLEEVINETL SSPLYKKQFEDELKKAAKDTAKESE*" gene complement(158515..159072) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" promotor_-10 complement(159104..159115) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(159116) /Source="Nicolas_upshifts" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" promotor_-35 complement(159129..159135) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(159149..159778) /Source="Nicolas_S_feature" /locus_tag="new_159149_159778_c" /HighExp="S3, T5.0H, S4, S8, M9-stat, T4.0H, T3.30H, S7, T3.0H, S6" /AntisenseName="kbaA" /AntisenseCor="7.9344921760152495E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S62" CDS 159182..159778 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8576055, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576055, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inner membrane protein involved in activation ofthe KinB signaling pathway to sporulation" /protein_id="NP_388037.1" /db_xref="EnsemblGenomes-Gn:BSU01560" /db_xref="EnsemblGenomes-Tr:CAB11932" /db_xref="GOA:P16449" /db_xref="InterPro:IPR024164" /db_xref="SubtiList:BG10643" /db_xref="UniProtKB/Swiss-Prot:P16449" /translation="MKSRGLVRFFFSILAVGALITSIVGFALKWGEYRGLFLTFEAGQ IFSVLFWFIGVGMIFSVISQMGFFVFLTVHRFALEILRSSSLWNLLQLFFILFVAFDL MYVRFLFFGESGESLAGYAWLPVFLLIFGVITAYIKQKQSSKKTFVSSLFLMVVITAL EWFPALRVNDEDWLYLMLFPLMACNAFQLLMLPKFAAK*" gene 159182..159778 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" S_feature 159779..160673 /Source="Nicolas_S_feature" /locus_tag="new_159779_160673" /HighExp="Lbstat, Lbtran, M0t90, M40t90, H2O2, BC, Glucon, S7, M40t45, S1" /AntisenseName="ybaN" /AntisenseCor="-2.6735901031407501E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S63" CDS complement(159779..160543) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 15598884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 15598884; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="polysaccharide deacetylase involved in sporulation" /protein_id="NP_388038.1" /db_xref="EnsemblGenomes-Gn:BSU01570" /db_xref="EnsemblGenomes-Tr:CAB11933" /db_xref="GOA:P50865" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014132" /db_xref="SubtiList:BG11416" /db_xref="UniProtKB/Swiss-Prot:P50865" /translation="MNHFYVWHIKRVKQLIIILIAAFAAASFFYIQRAVPLPVFSTDT GPKAIYKGETDSKDISLTFDISWGDERAEPILNTLKANGIKNATFFLSASWAERHPDT VARIVKDGHQIGSMGYAYKNYANLESSEIKKDMNRAQTAFEKLGVKDIQLLRPPTGQF NKNVLKVAKQYNYTVVHYSVNSQDWTNPGVEKIIDNVTKQVSGGDIILLHASDSAKQT EEALPDIIHQLKEKGLKNVTVGDLIANSDAKSAEVK*" gene complement(159779..160543) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" promotor_-10 complement(160574..160592) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(160594) /Source="Nicolas_upshifts" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" promotor_-35 complement(160608..160613) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 160651..160658 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 160673..160692 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 160675..160892 /Source="Nicolas_S_feature" /locus_tag="new_160675_160892" /HighExp="Diami, LBGstat, UNK1, H2O2, MG 15, Oxctl, MG-0.1, BMM, T-1.10H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S64" upshifts 160675 /Source="Nicolas_upshifts" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" rRNA 160893..162445 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 160893..162445 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" rRNA 162610..165535 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 162610..165535 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" rRNA 165591..165707 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" /product="ribosomal RNA-5S" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 165591..165707 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" tRNA 165754..165825 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 165754..165825 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" tRNA 165830..165902 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(GGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 165830..165902 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" tRNA 165959..166033 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 165959..166033 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" tRNA 166064..166140 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg(AGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 166064..166140 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" tRNA 166168..166244 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 166168..166244 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" tRNA 166253..166328 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 166253..166328 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" rRNA 166500..168053 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 166500..168053 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" rRNA 168218..171141 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 168218..171141 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" rRNA 171197..171314 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 171197..171314 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" rRNA 171498..173049 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 171498..173049 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" rRNA 173214..176141 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 173214..176141 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" rRNA 176197..176315 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 176197..176315 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" S_feature 176316..176924 /Source="Nicolas_S_feature" /locus_tag="new_176316_176924" /HighExp="G180, G135, C30, Oxctl, Paraq, Cold, G150, H2O2, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S65" promotor_-35 176892..176896 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 176912..176931 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 176926..177082 /Source="Nicolas_S_feature" /locus_tag="new_176926_177082" /HighExp="LBGstat, G180, G135, dia15, C30, Oxctl, LPhT, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S66" upshifts 176926 /Source="Nicolas_upshifts" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" CDS 177083..178519 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388039.1" /db_xref="EnsemblGenomes-Gn:BSU01580" /db_xref="EnsemblGenomes-Tr:CAB11934" /db_xref="GOA:P55189" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR018045" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11562" /db_xref="UniProtKB/Swiss-Prot:P55189" /translation="MNNSFTLKQQWFGNIRKDILAGILVALALIPEAIGFSIIAGVDP MVGLYASFCIAIIISIFGGRPGMISAATGSMAVVMVSLVADHGLQYLFAATILTGIIQ VILGISKIARLMKFIPRSVMIGFVNALAILIFSAQLPQFEGASWSMYAMLAGSLVIIY VLPRFTTAVPSPLVAIIVMTIIAVTFHVDVRTVGDMGNISSSLPHFLIPDVPFTFETL QIIFPYSIALAFVGLLESLLTAQIIDEMTDTDSDKNKESRGQGIANIVTGFFGGMAGC AMIGQSVINTKAGGRGRLSAFVAGAFLMFLIAVLSHVVVKIPMAALVAVMVMVSVGTF DWSSLKGLKKAPLTDSIVMVVTVVTVVVTDDLSKGVFVGVLLSAVFFVAKISKLKIVS HAEDQKLRTYQVKGQIFFASVTDLTNAFIYQEDIERVVIDLTEAHVWDDSGAAALDKI VAKFKEQGIEAELKGLNKASKSLMKQMA*" gene 177083..178519 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" downshifts 178508 /Source="Nicolas_upshifts" /id="D56" /incds=0 /nref=144 /ntot=228 /MaxReadThrough="2.81758" /MaxDrop="4.71162" /score="18.4600501" /energy="-12" /TU="NA" /idTUdmin="U111" /TUdmin="-2" /isTUend="TRUE" promotor_-35 178562..178567 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 178580..178599 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 178598 /Source="Nicolas_upshifts" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" CDS 178665..179585 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium dependent transporter" /protein_id="NP_388040.2" /db_xref="EnsemblGenomes-Gn:BSU01590" /db_xref="EnsemblGenomes-Tr:CAB11935" /db_xref="GOA:P55190" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG11563" /db_xref="UniProtKB/Swiss-Prot:P55190" /translation="MPLLTPTSVVLGVLLSQFLNGYEWAVPWIFAFITFAGSLSANFQ SLRHALSHPLPMILALFVLHIFMPLFAWGSGHLIFKGDPLTITGLTLAVVIPTGITSL IWAAMYKGNVGLTLSIILVDTVLSPLIVPLSLSLLAGAQVHMDVWGMMKGLIVMVVIP SFLGMLFNQMSSPERTAFVSSALSPFSKLCLMAVIAINSSAIAPYFKSIDLRFAGIAV TVFFIALTGYAAAWLIGKMMKRRQEEIVSLIFTGGMRNISAGAVLAVTFFPSQVAVPV VIGMLFQQILAALFGYMLNRFELKPMLQKA*" gene 178665..179585 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" downshifts 179566 /Source="Nicolas_upshifts" /id="D57" /incds=0 /nref=33 /ntot=224 /MaxReadThrough="1.3063" /MaxDrop="3.58628" /score="13.3102824" /energy="-10.5" /TU="NA" /idTUdmin="U112" /TUdmin=0 /isTUend="TRUE" CDS complement(179595..180347) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 2974033, 17725565, 22210890, 28283524" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 2974033, 17725565, 22210890, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-chelator (enterobactin family) esterase" /protein_id="NP_388041.2" /db_xref="EnsemblGenomes-Gn:BSU01600" /db_xref="EnsemblGenomes-Tr:CAB11936" /db_xref="GOA:P55192" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11565" /db_xref="UniProtKB/Swiss-Prot:P55192" /translation="MKGSLSEHKAGNRRFTLYLPPSYSTDSGGFPAVYVQDGSSLFQN QIELLESAFQQQRLPELVLIGIEPENRLDEYTPWPAASLSDRFTDFGGMGYHYLSDIT NQFIPLIEENWNVTREPQSRGMIGASLGGLISMFAILKYPSMFGKIGSISGSYWYENA AETIHISSLKPGTARVFMSIGSEEGREKQSIQRHMLKKTKQVHQSLKEKGFTEDQLCL SIEKGAVHHHKYFCKQFINALEWLYGKNRSTL*" gene complement(179595..180347) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" downshifts complement(179619) /Source="Nicolas_upshifts" /id="D58" /incds=0 /nref=15 /ntot=115 /MaxReadThrough="0.3819" /MaxDrop="4.57603" /score="25.9728338" /energy="-10.5" /TU="NA" /idTUdmin="U114" /TUdmin=1 /isTUend="TRUE" CDS complement(180344..181354) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2651410, 15849754, 16850406, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-uptake protein" /protein_id="NP_388042.2" /db_xref="EnsemblGenomes-Gn:BSU01610" /db_xref="EnsemblGenomes-Tr:CAB11937" /db_xref="GOA:P40411" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10837" /db_xref="UniProtKB/Swiss-Prot:P40411" /translation="MAKKYALFIALILVVSYFSLTSGSFSVRPAELLSTLFQIDPNPQ YEILLFDLRLPRVVMAAIIGLGLGIAGAVIQAITRNGLADPGILGINAGAGAGIVAFM LLFQGQKEVTSIAAAMGMPLFGLIGGLIAAILIYIFAWHRGNLDSGRIILVGIAINSG FSALSLFLSLKMDPQDYQMAMVWKNGSIWSANWTYITAVLPWMLLFIPILIGKSRLLD TIRFDEDTVRSLGISSNKEKTILLVACVAIISACVSVAGSMAFVGLIAPHISRRLAGV EHRYILPLSGLIGMLLVISADFAGKLFFQPAEVPAGIILAILGVPYFLYLLFKQKKGE NA*" gene complement(180344..181354) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" CDS complement(181347..182351) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2651410, 15849754, 16850406, 17725565; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin permease" /protein_id="NP_388043.1" /db_xref="EnsemblGenomes-Gn:BSU01620" /db_xref="EnsemblGenomes-Tr:CAB11938" /db_xref="GOA:P40410" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10836" /db_xref="UniProtKB/Swiss-Prot:P40410" /translation="MYSKQWTRIILITSPFAIALSLLLSILYGAKHLSTDIVFTSLIH FDPGNTDHQIIWHSRIPRAAGALLIGAALAVSGALMQGITRNYLASPSIMGVSDGSAF IITLCMVLLPQSSSIEMMIYSFIGSALGAVLVFGLAAMMPNGFTPVQLAIIGTVTSML LSSLSAAMSIYFQISQDLSFWYSARLHQMSPDFLKLAAPFFLIGIIMAISLSKKVTAV SLGDDISKSLGQKKKTIKIMAMLSVIILTGSAVALAGKIAFVGLVVPHITRFLVGSDY SRLIPCSCILGGIFLTLCDLASRFINYPFETPIEVVTSIIGVPFFLYLIKRKGGEQNG *" gene complement(181347..182351) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" CDS complement(182370..183323) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8388528, 16889643, 17725565, 21802011, 22303020, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8388528, 16889643, 17725565, 21802011, 22303020, 25355936; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin-binding lipoprotein" /protein_id="NP_388044.1" /db_xref="EnsemblGenomes-Gn:BSU01630" /db_xref="EnsemblGenomes-Tr:CAB11939" /db_xref="GOA:P40409" /db_xref="InterPro:IPR002491" /db_xref="PDB:2PHZ" /db_xref="PDB:2WHY" /db_xref="PDB:2WI8" /db_xref="PDB:2XUZ" /db_xref="PDB:2XV1" /db_xref="SubtiList:BG10835" /db_xref="UniProtKB/Swiss-Prot:P40409" /translation="MKKISLTLLILLLALTAAACGSKNESTASKASGTASEKKKIEYL DKTYEVTVPTDKIAITGSVESMEDAKLLDVHPQGAISFSGKFPDMFKDITDKAEPTGE KMEPNIEKILEMKPDVILASTKFPEKTLQKISTAGTTIPVSHISSNWKENMMLLAQLT GKEKKAKKIIADYEQDLKEIKTKINDKAKDSKALVIRIRQGNIYIYPEQVYFNSTLYG DLGLKAPNEVKAAKAQELSSLEKLSEMNPDHIFVQFSDDENADKPDALKDLEKNPIWK SLKAVKEDHVYVNSVDPLAQGGTAWSKVRFLKAAAEKLTQN*" gene complement(182370..183323) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" promotor_-35 182683..182689 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 182704..182722 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 182713 /Source="Nicolas_upshifts" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(183354..183373) /Source="Nicolas_upshift_promotors" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(183361) /Source="Nicolas_upshifts" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" CDS complement(183414..185003) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16889643, 17725565, 17962296, 22210890" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16889643, 17725565, 17962296, 22210890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AraC/XylS family) of synthesis and uptake of the siderophore bacillibactin" /protein_id="NP_388045.1" /db_xref="EnsemblGenomes-Gn:BSU01640" /db_xref="EnsemblGenomes-Tr:CAB11940" /db_xref="GOA:P40408" /db_xref="InterPro:IPR002491" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG10834" /db_xref="UniProtKB/Swiss-Prot:P40408" /translation="MQNAVIYQPVQIEYLKKTSDLFSEQQLADSFVLIFHLKGNGYIS IGTNTNPLQKKTLYVCPPNETFGFTPAADGHIDACIIRLLSYIKETGQDIFTPCTESE LAKLKLMNVSHIENLAVRLQELAALWNESSQLSQLKCVIEVQSLIYDLFTASLSDQTD THSAIEKTKHYIETHADTKITLAQLSQMAGISAKHYSESFKKWTGQSVTEFITKTRIT KAKRLMAKSNCKLKEIAHQTGYQDEFYFSRIFKKYTGCSPTSYMKKRRKKIAAYGRGT MGHLIPLHHIPFAAALHPKWTSYYYQHYSTDIPVQLSAYRFNEKWEENLYTLSQAEPD VIVSMDSISPEEQDRLNRIAEVMYLPSEESWRTHFLQTASFLKEESEAEKWLADYDQQ TTAAKKTLQHVQGLRFLFLRLHKQNFYLAHNRSVREVFFGDLGFSSATTADTPSEQAI SLENIANYQADCMMLFLFKEPETIAYYQQLQQTEAWQNLSAVRDNRVYLLSLDPWNEY SACGHERIVQQTVSLLSGDCP*" gene complement(183414..185003) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" promotor_-10 complement(185044..185063) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(185056) /Source="Nicolas_upshifts" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" promotor_-35 complement(185078..185085) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(185165) /Source="Nicolas_upshifts" /id="D59" /incds=0 /nref=19 /ntot=58 /MaxReadThrough="1.28464" /MaxDrop="7.13916" /score="9.64466628" /energy="-10.1" /TU="NA" /idTUdmin="U116" /TUdmin=0 /isTUend="TRUE" CDS complement(185194..186438) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388046.1" /db_xref="EnsemblGenomes-Gn:BSU01650" /db_xref="EnsemblGenomes-Tr:CAB11941" /db_xref="InterPro:IPR008302" /db_xref="SubtiList:BG10833" /db_xref="UniProtKB/Swiss-Prot:P40407" /translation="MRKTIFAFLTGLMMFGTITAASASPDSKNQTAKKPKVQTGIDTL LPDYKKQLKGKRIGLITNPAGVNTSLKSSVDILYENPDIKLTALFGPEHGVRGDAQAG DEVGSYIDEKTGVPVYSLYGKTKKPTPEMLKNVDILMFDIQDVGTRFYTYIYTMAYAM EAAKENGIPFMVLDRPNPQGGNHIEGPILEPEYASFVGLYPIPLKHGMTIGELASLFN KEFSIDADLTVVKMKHWKRKMDFDDTRLPFVLPSPNMPTVESTFVYPATGLIEGTNIS EGRGTTKPFELIGAPFIKSTELEETLNSLHLPGVTFRAASFTPTFSKHQGTLCHGVQL YVTDRDKFEAVKTGLSVIKTIHDLYPEDFEFLSTGSFDKLAGNGWIRTKIENGTSVEN IINSYEKTLQQFSKTRKKYLIY*" gene complement(185194..186438) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" downshifts complement(185215) /Source="Nicolas_upshifts" /id="D60" /incds=0 /nref=11 /ntot=122 /MaxReadThrough="7.66074" /MaxDrop="4.10379" /score="9.64466628" /energy="-10.1" /TU="U116" /idTUdmin="U116" /TUdmin="-50" /isTUend="FALSE" CDS complement(186452..188380) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" /EC_number="3.2.1.52" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8063094, 20400549, 20826810, 23177201, 26963691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8063094, 20400549, 20826810, 23177201, 26963691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosaminidase lipoprotein" /protein_id="NP_388047.1" /db_xref="EnsemblGenomes-Gn:BSU01660" /db_xref="EnsemblGenomes-Tr:CAB11942" /db_xref="GOA:P40406" /db_xref="InterPro:IPR001764" /db_xref="InterPro:IPR002772" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR019800" /db_xref="InterPro:IPR036881" /db_xref="InterPro:IPR036962" /db_xref="PDB:3BMX" /db_xref="PDB:3LK6" /db_xref="PDB:3NVD" /db_xref="PDB:4GYJ" /db_xref="PDB:4GYK" /db_xref="SubtiList:BG10832" /db_xref="UniProtKB/Swiss-Prot:P40406" /translation="MRPVFPLILSAVLFLSCFFGARQTEASASKRAIDANQIVNRMSL DEKLGQMLMPDFRNWQKEGESSPQALTKMNDEVASLVKKYQFGGIILFAENVKTTKQT VQLTDDYQKASPKIPLMLSIDQEGGIVTRLGEGTNFPGNMALGAARSRINAYQTGSII GKELSALGINTDFSPVVDINNNPDNPVIGVRSFSSNRELTSRLGLYTMKGLQRQDIAS ALKHFPGHGDTDVDSHYGLPLVSHGQERLREVELYPFQKAIDAGADMVMTAHVQFPAF DDTTYKSKLDGSDILVPATLSKKVMTGLLRQEMGFNGVIVTDALNMKAIADHFGQEEA VVMAVKAGVDIALMPASVTSLKEEQKFARVIQALKEAVKNGDIPEQQINNSVERIISL KIKRGMYPARNSDSTKEKIAKAKKIVGSKQHLKAEKKLAEKAVTVLKNEQHTLPFKPK KGSRILIVAPYEEQTASIEQTIHDLIKRKKIKPVSLSKMNFASQVFKTEHEKQVKEAD YIITGSYVVKNDPVVNDGVIDDTISDSSKWATVFPRAVMKAALQHNKPFVLMSLRNPY DAANFEEAKALIAVYGFKGYANGRYLQPNIPAGVMAIFGQAKPKGTLPVDIPSVTKPG NTLYPLGYGLNIKTGRPL*" gene complement(186452..188380) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" CDS complement(188408..189733) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16452451, 20400549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16452451, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidase hydrolyzing N-acetylmuramyl-L-Ala bond of MurNAc peptides" /protein_id="NP_388048.2" /db_xref="EnsemblGenomes-Gn:BSU01670" /db_xref="EnsemblGenomes-Tr:CAB11943" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR022849" /db_xref="SubtiList:BG11566" /db_xref="UniProtKB/Swiss-Prot:O05213" /translation="MKTKTLFIFSAILTLSIFAPNETFAQTAGNLIEPKIINAETAQF STKKLRKVDQMIERDIAAGFPGAVLVVVKDGRIIKKAAYGYSKKYEGSELLRRPAKMK TRTMFDLASNTKMYATNFALQRLVSQGKLDVYEKVSAYLPGFKDQPGDLIKGKDKIRV IDVLQHQSGLPSSFYFYTPEKAGKYYSQERDKTIEYLTKIPLDYQTGTKHVYSDIGYM LLGCIVEKLTGKPLDVYTEQELYKPLRLKHTLYNPLQKGFKPKQFAATERMGNTRDGV IQFPNIRTNTLQGEVHDEKAFYSMDGVSGHAGLFSNADDMAILLQVMLNKGSYRNISL FDQKTADLFTAPSATDPTFALGWRRNGSKSMEWMFGPHASENAYGHTGWTGTVTIIDP AYNLGIALLTNKKHTPVIDPEENPNVFEGDQFPTGSYGSVITAIYEAME*" gene complement(188408..189733) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" CDS complement(189790..191157) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" /EC_number="2.7.1.192" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15060041, 15849754, 16850406, 10627040, 20400549, 22960854; Product type t : transporter" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid PTS permease-MurP subunit" /protein_id="NP_388049.3" /db_xref="EnsemblGenomes-Gn:BSU01680" /db_xref="EnsemblGenomes-Tr:CAB11944" /db_xref="GOA:Q797S1" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11567" /db_xref="UniProtKB/Swiss-Prot:Q797S1" /translation="MSKENNYHHLAQKILELCGGKSNISSYTHCMTRLRITPYDESKA DAQALRKLDGVLGVVEAETLQIILGTGVVNHVTAAFSKLVSAEEGADVKEAAAKKKAD INRKNATPFKLFLRKIASIFIPLIPALVASGLITGITKAIIQAGWLSADSQIAIILTV IGSGLFTYLGILVGINASKEFGGTPALGALAGILIINPEIAKISLFGEELLPGRGGLI GVLFAAIFIAYTEQFIRRFIPQSLDIIVTPTVSLLITGIVTYVVFMPLGGFISDAITS GLLSILDIGGIAAGFILGATFLPLVVTGLHQGLTPVHMELINSIGNDPLLPILAMGGA GQVGAAFAVFVKTKKTTLRKAIAGGLPSGLLGIGEPLIFGVTLPLGRPFLTACLGAGI GGAFQAYFQVATIAIGVSGLPLSFLVLPSQIILYIVGLFISYAAGFLLTYAFGYKDEM ASQFD*" gene complement(189790..191157) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" CDS complement(191183..192034) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20400549; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator MurR-N-acetylmuramic acid" /protein_id="NP_388050.1" /db_xref="EnsemblGenomes-Gn:BSU01690" /db_xref="EnsemblGenomes-Tr:CAB11945" /db_xref="GOA:Q45581" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="PDB:2O3F" /db_xref="SubtiList:BG11569" /db_xref="UniProtKB/Swiss-Prot:Q45581" /translation="MATGGLAIIQSMKHKLPPSERKLADYILAHPHKAIESTVNEISA LANSSDAAVIRLCKSLGLKGFQDLKMRVAGDLAKPTFQGYRDIVPHEPLPSISEKTAG NAIQAIQDTSDLMDYKELERAVSLLLKAHTVHFIGLGASGIVAKDAQQKWLRIHKQAT AFTDTHLVASLIANADKDDIVFAISFSGETQEIVELFAMAKEKGITTISLTQFSQTSV SALADVPLYTAHSNEALIRSAATSSRLAQLFIIDVLFLGMAAEQYETTTGYIDKTRAA IQSMRIK*" gene complement(191183..192034) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" CDS complement(192051..192965) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" /EC_number="4.2.1.126" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15983044, 20400549, 16452451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lactyl ether N-acetylmuramic-6-phosphate acid etherase" /protein_id="NP_388051.1" /db_xref="EnsemblGenomes-Gn:BSU01700" /db_xref="EnsemblGenomes-Tr:CAB11946" /db_xref="GOA:Q45582" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005486" /db_xref="InterPro:IPR005488" /db_xref="SubtiList:BG11570" /db_xref="UniProtKB/Swiss-Prot:Q45582" /translation="MSEPLNLHRLTTESRNSQTVEIHKANTLGILKMINNEDMKVAAA VQEVLPDIKTAVDCAYESFQNGGRLIYTGAGTSGRLGVMDAVECPPTYSVSPDQVIGI MAGGPEAFLQAAEGIEDSEEAGAEDLRNIQLTSNDTVIAIAASGRTPYAAGALRYARK VGAHTIALTCNENSAISKDADHSIEVVVGPEAITGSTRMKAATAHKMILNMISTAVMV KIGKVYENLMVDVNVSNKKLKERAISIIQSLTNASYDTARYTLEQADHHVKTAIVMLK TSTDQKQAQTLLDEANGFIDKAIEHYHP*" gene complement(192051..192965) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" promotor_-10 complement(192996..193014) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(193009) /Source="Nicolas_upshifts" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" promotor_-35 complement(193030..193037) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(193075..193557) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_388052.2" /db_xref="EnsemblGenomes-Gn:BSU01710" /db_xref="EnsemblGenomes-Tr:CAB11947" /db_xref="GOA:Q45583" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11571" /db_xref="UniProtKB/Swiss-Prot:Q45583" /translation="MTQDISLSFYKPEHLPELQSFTLTNDDKRFTSLPKEVLSQALGI QDRYPVVILKDDLPVGFFILHASKETLASYSNNPFALLLSSLSLTAVHHGKGYAKKAM LLLPAFVSGYFPWCDEIILAVNHLNIRAKHLYMKSGFLDKGRRRIGPLGEQLILHHFL *" gene complement(193075..193557) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" CDS complement(193570..194025) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388053.2" /db_xref="EnsemblGenomes-Gn:BSU01720" /db_xref="EnsemblGenomes-Tr:CAB11948" /db_xref="InterPro:IPR007553" /db_xref="SubtiList:BG11572" /db_xref="UniProtKB/Swiss-Prot:Q45584" /translation="MILVSSCLGGIECRYNGSHAASEKIRKLVDEKKAVMACPELLGG FSTPREPAEIIGGTGEDVLNGTAKIVTASGEDVTELYMEGAAKTLAYAKEINASAVIL KENSPSCGSGFIYNGTFSGKKITGSGVTAALLKQAGYRVISENELNDIL*" gene complement(193570..194025) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" promotor_-10 complement(194051..194070) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(194072) /Source="Nicolas_upshifts" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" promotor_-35 complement(194085..194086) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 194145..194152 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" promotor_-10 194167..194186 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" upshifts 194178 /Source="Nicolas_upshifts" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" tRNA 194205..194279 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 194205..194279 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" tRNA 194283..194358 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 194283..194358 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" tRNA 194363..194435 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 194363..194435 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" tRNA 194458..194542 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 194458..194542 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" tRNA 194547..194621 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 194547..194621 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" downshifts 194624 /Source="Nicolas_upshifts" /id="D61" /incds=0 /nref=10 /ntot=91 /MaxReadThrough="4.25215" /MaxDrop="3.84626" /score="25.5087424" /energy="-11.4" /TU="U118" /idTUdmin="U118" /TUdmin="-176" /isTUend="FALSE" S_feature 194669..194786 /Source="Nicolas_S_feature" /locus_tag="new_194669_194786" /HighExp="Paraq, BMM, H2O2, Heat, G180, G135, Oxctl, G150, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S67" promotor_-35 194787..194796 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" upshifts 194788 /Source="Nicolas_upshifts" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" promotor_-10 194808..194823 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" CDS 194849..195412 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11866510, 15130127, 16629676, 21542858, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11866510, 15130127, 16629676, 21542858, 28319136, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor W" /protein_id="NP_388054.1" /db_xref="EnsemblGenomes-Gn:BSU01730" /db_xref="EnsemblGenomes-Tr:CAB11949" /db_xref="GOA:Q45585" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014294" /db_xref="InterPro:IPR036388" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11573" /db_xref="UniProtKB/Swiss-Prot:Q45585" /translation="MEMMIKKRIKQVKKGDQDAFADIVDIYKDKIYQLCYRMLGNVHE AEDIAQEAFIRAYVNIDSFDINRKFSTWLYRIATNLTIDRIRKKKPDYYLDAEVAGTE GLTMYSQIVADGVLPEDAVVSLELSNTIQQKILKLPDKYRTVIVLKYIDELSLIEIGE ILNIPVGTVKTRIHRGREALRKQLRDL*" gene 194849..195412 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" CDS 195426..196052 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15130127, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 28319136, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(W) factor" /protein_id="NP_388055.1" /db_xref="EnsemblGenomes-Gn:BSU01740" /db_xref="EnsemblGenomes-Tr:CAB11950" /db_xref="GOA:Q45588" /db_xref="InterPro:IPR027383" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11574" /db_xref="UniProtKB/Swiss-Prot:Q45588" /translation="MSCPEQIVQLMHMHLDGDILPKDEHVLNEHLETCEKCRKHFYEM EKSIALVRSTSHVEAPADFTANVMAKLPKEKKRASVKRWFRTHPVIAAAAVFIILMGG GFFNSWHNDHNFSVSKQPNLVVHNHTVTVPEGETVKGDVTVKNGKLIIKGKIDGDVTV VNGEKYMASAGQVTGQIEEINQLFDWTWYKMKSAGKSVLDAFNPNGEE*" gene 195426..196052 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" downshifts complement(195844) /Source="Nicolas_upshifts" /id="D62" /incds=1 /nref=2 /ntot=181 /MaxReadThrough="1.52124" /MaxDrop="3.24828" /score="0.305471631" /energy="-6.9" /TU="NA" /idTUdmin="U120" /TUdmin=0 /isTUend="TRUE" promotor_no_box complement(196002..196102) /Source="Nicolas_upshift_promotors" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts 196032 /Source="Nicolas_upshifts" /id="D63" /incds=0 /nref=251 /ntot=269 /MaxReadThrough="4.26924" /MaxDrop="8.34597" /score="7.39786279" /energy="-10.8" /TU="U119" /idTUdmin="U119" /TUdmin="-88" /isTUend="FALSE" upshifts complement(196042) /Source="Nicolas_upshifts" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 196101..196108 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-35" promotor_-10 196123..196142 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-10" S_feature 196132..196212 /Source="Nicolas_S_feature" /locus_tag="new_196132_196212" /HighExp="dia5, Diami, H2O2, dia15, G135, Cold, G180, Paraq, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA" /TUlongPSig="1, 1" /label="S68" upshifts 196132 /Source="Nicolas_upshifts" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" CDS 196213..197034 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" /EC_number="2.7.7.85" /function="16.13: Shape" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase" /protein_id="NP_388056.2" /db_xref="EnsemblGenomes-Gn:BSU01750" /db_xref="EnsemblGenomes-Tr:CAB11951" /db_xref="GOA:Q45589" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR034701" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG11577" /db_xref="UniProtKB/Swiss-Prot:Q45589" /translation="MAFEDIPFLQYLGNAVDILLVWYVIYKLIMVIRGTKAVQLLKGI VVIVLVRMASQYLGLSTLQWLMDQAITWGFLAIIIIFQPELRRALEQLGRGRFFSRSG TPVEEAQQKTIEAITKAINYMAKRRIGALLTIERDTGMGDYIETGIPLNAKVSSELLI NIFIPNTPLHDGAVIMKNNEIAAAACYLPLSESPFISKELGTRHRAAVGISEVTDSLT IIVSEETGGVSVAKNGDLHRELTEEALKEMLEAEFKKNTRDTSSNRWYWRGKKNG*" gene 196213..197034 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" CDS 197027..198478 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" /experiment="publication(s) with functional evidences, PMID:16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of diadenylate cyclase activity" /protein_id="NP_388057.2" /db_xref="EnsemblGenomes-Gn:BSU01760" /db_xref="EnsemblGenomes-Tr:CAB11952" /db_xref="GOA:O34659" /db_xref="InterPro:IPR012505" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12703" /db_xref="UniProtKB/Swiss-Prot:O34659" /translation="MDKFLNNRWAVKIIALLFALLLYVAVNSNQAPTPKKPGESFFPT STTDEATLTDIPVKAYYDDENYVVTGVPQTVNVTIKGSTSAVKKARQTKNFEIYADME HLKTGTHKVELKAKNVSDGLTISINPSVTTVTIQERTTKSFPVEVEYYNKSKMKKGYS PEQPIVSPKNVQITGSKNVIDNISLVKASVNLENADETIEKEAKVTVYDKDGNALPVD VEPSVIKITVPVTSPSKKVPFKIERTGSLPDGVSIANIESSPSEVTVYGSQDVLDSLE FIDGVSLDLSKINKDSDIEADIPLPDGVKKISPSKVTLHIEVDSEADQKFENVPIKTV GLSSSQNIEFLDPESQAIDVTAKGSPTNINKLKKSDIELYVNVSDLEDGEHSVKLEVN GPQNVTWSLGRKNAKIKLTSKKSNTSTNDNSSNTSGNQDTDKQTNDQKNNQQEDTKNT DKNNNDQNQDGNKDQNQDQDEDESTANSQSSSE*" gene 197027..198478 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" CDS 198497..199843 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" /EC_number="5.4.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10671448, 10913078, 12089032, 21154411, 26240071, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671448, 10913078, 12089032, 21154411, 26240071, 27074767; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoglucosamine mutase" /protein_id="NP_388058.1" /db_xref="EnsemblGenomes-Gn:BSU01770" /db_xref="EnsemblGenomes-Tr:CAB11953" /db_xref="GOA:O34824" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR006352" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG12704" /db_xref="UniProtKB/Swiss-Prot:O34824" /translation="MGKYFGTDGVRGVANSELTPELAFKVGRFGGYVLTKDKQRPKVL IGRDTRISGHMLEGALVAGLLSIGAEVMRLGVISTPGVSYLTKAMDAEAGVMISASHN PVQDNGIKFFGGDGFKLSDEQEAEIERLMDEPEDKLPRPVGADLGLVNDYFEGGQKYL QFLKQTADEDFTGIHVALDCANGATSSLATHLFADLDADVSTMGTSPNGLNINDGVGS THPEALSAFVKEKNADLGLAFDGDGDRLIAVDEKGNIVDGDQIMYICSKHLKSEGRLK DDTVVSTVMSNLGFYKALEKEGIKSVQTAVGDRYVVEAMKKDGYNVGGEQSGHLIFLD YNTTGDGLLSAIMLMNTLKATGKPLSELAAEMQKFPQLLVNVRVTDKYKVEENEKVKA VISEVEKEMNGDGRILVRPSGTEPLVRVMAEAKTKELCDEYVNRIVEVVRSEMGLE*" gene 198497..199843 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" downshifts 199838 /Source="Nicolas_upshifts" /id="D64" /incds=0 /nref=126 /ntot=216 /MaxReadThrough="5.32721" /MaxDrop="5.02497" /score="13.5044076" /energy="-17.5" /TU="U121" /idTUdmin="U121" /TUdmin="-110" /isTUend="FALSE" promotor_-35 199862..199870 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 199878 /Source="Nicolas_upshifts" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" promotor_-10 199884..199903 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 199930..199935 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 199951..199970 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 199957 /Source="Nicolas_upshifts" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" misc_feature 200001..200017 /Source="Nicolas_upshift_promotors" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 200014 /Source="Nicolas_upshifts" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" misc_RNA 200017..200187 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" /product="riboswitch and ribozyme (GlmS-glucosamine-6-P)" /experiment="publication(s) with functional evidences, PMID:16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261; Product type n: RNA" gene 200017..200187 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" S_feature 200188..200276 /Source="Nicolas_S_feature" /locus_tag="new_200188_200276" /HighExp="M40t90, M0t90, M9-stat, Lbstat, T2.30H, T2.0H, T3.0H, T1.30H, T1.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.498, 0.999, 0.754" /TUlongSig="SigA, SigWXY, SigA" /TUlongPSig="1, 1, 1" /label="S69" CDS 200277..202079 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" /EC_number="2.6.1.16" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15029187, 17114942, 17283212, 17322533, 23874669; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine-D-fructose-6-phosphate amidotransferase" /protein_id="NP_388059.1" /db_xref="EnsemblGenomes-Gn:BSU01780" /db_xref="EnsemblGenomes-Tr:CAB11954" /db_xref="GOA:P0CI73" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005855" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR035466" /db_xref="InterPro:IPR035490" /db_xref="SubtiList:BG10948" /db_xref="UniProtKB/Swiss-Prot:P0CI73" /translation="MCGIVGYIGQLDAKEILLKGLEKLEYRGYDSAGIAVANEQGIHV FKEKGRIADLREVVDANVEAKAGIGHTRWATHGEPSYLNAHPHQSALGRFTLVHNGVI ENYVQLKQEYLQDVELKSDTDTEVVVQVIEQFVNGGLETEEAFRKTLTLLKGSYAIAL FDNDNRETIFVAKNKSPLLVGLGDTFNVVASDAMAMLQVTNEYVELMDKEMVIVTDDQ VVIKNLDGDVITRASYIAELDASDIEKGTYPHYMLKETDEQPVVMRKIIQTYQDENGK LSVPGDIAAAVAEADRIYIIGCGTSYHAGLVGKQYIEMWANVPVEVHVASEFSYNMPL LSKKPLFIFLSQSGETADSRAVLVQVKALGHKALTITNVPGSTLSREADYTLLLHAGP EIAVASTKAYTAQIAVLAVLASVAADKNGINIGFDLVKELGIAANAMEALCDQKDEME MIAREYLTVSRNAFFIGRGLDYFVCVEGALKLKEISYIQAEGFAGGELKHGTIALIEQ GTPVFALATQEHVNLSIRGNVKEVAARGANTCIISLKGLDDADDRFVLPEVNPALAPL VSVVPLQLIAYYAALHRGCDVDKPRNLAKSVTVE*" gene 200277..202079 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" S_feature complement(201802..202546) /Source="Nicolas_S_feature" /locus_tag="new_201802_202546_c" /HighExp="S8, S7, S6, S5, S4, BC, S3, Sw, C30, LoTm" /AntisenseName="glmS" /AntisenseCor="4.5056549205256403E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S70" downshifts 202065 /Source="Nicolas_upshifts" /id="D65" /incds=0 /nref=260 /ntot=277 /MaxReadThrough="3.18134" /MaxDrop="7.61794" /score="13.5044076" /energy="-17.5" /TU="NA" /idTUdmin="U122" /TUdmin=2 /isTUend="TRUE" CDS 202126..202266 /gene="ybbU" /locus_tag="BSU_01790" /old_locus_tag="BSU01790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513939.1" /translation="MSKSERTSTVEKWIKEVDGTGPDYRSTMAIDLRCFLIRSVNQVK RH*" gene 202126..202266 /gene="ybbU" /locus_tag="BSU_01790" /old_locus_tag="BSU01790" CDS complement(202547..203458) /gene="alkA" /locus_tag="BSU_01800" /old_locus_tag="BSU01800" /EC_number="3.2.2.21" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7565865, 8376346, 16468998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7565865, 8376346, 16468998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-3-methyladenine glycosylase; prophage 1 region" /protein_id="NP_388061.1" /db_xref="EnsemblGenomes-Gn:BSU01800" /db_xref="EnsemblGenomes-Tr:CAB11956" /db_xref="GOA:P37878" /db_xref="InterPro:IPR000035" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR012904" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR037046" /db_xref="SubtiList:BG10165" /db_xref="UniProtKB/Swiss-Prot:P37878" /translation="MTWHEVNDVIVITLPEIFDMNANLGYLTREKNECMYEIENNIIT KVIAIGEIRSLVQVSVINNKQMIVQFLNDSRPVEQWKREEIVKYIHEWFDLDNDLTPF YEMAKADPLLKMPARKFYGLRVIGIPDLFEALCWGVLGQQINLAFAYSLKKQFVEAFG DSIEWNGKKYWVFPPYERIARLTPTDLADIKMTVKKSEYIIGIARLMASGELSREKLM KMNFKDAEKNLIKIRGIGPWTANYVLMRCLRFPTAFPIDDVGLIHSIKILRNMNRKPT KDEILEISVPWKEWQSYATFYLWRVLY*" gene complement(202547..203458) /gene="alkA" /locus_tag="BSU_01800" /old_locus_tag="BSU01800" misc_feature complement(203505..203524) /Source="Nicolas_upshift_promotors" /id="U125" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.947052947052947" /psig="0.963036963036963" /xcortree=772 /SigmaFactorBS="aaaaaataaggtggttagaatgtaatagcaagataacaaaat gagtaaagatgattaTGTGATAAACTAATTTCAACcagcgtgagttttcttataatta t" /listShort="alkA, S70" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(203521) /Source="Nicolas_upshifts" /id="U125" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.947052947052947" /psig="0.963036963036963" /xcortree=772 /SigmaFactorBS="aaaaaataaggtggttagaatgtaatagcaagataacaaaat gagtaaagatgattaTGTGATAAACTAATTTCAACcagcgtgagttttcttataatta t" /listShort="alkA, S70" /GFF_Attribute="listLong" promotor_-35 203570..203576 /Source="Nicolas_upshift_promotors" /id="U126" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.994005994005994" /xcortree=376 /SigmaFactorBS="ttgttatcttgctattacattctaaccACCTTATttttttct atttatGAGGTTATAGTGTAGTTATCaagaatgctaaacgggagtagataaaaatggc c" /listShort="adaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 203591..203610 /Source="Nicolas_upshift_promotors" /id="U126" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.994005994005994" /xcortree=376 /SigmaFactorBS="ttgttatcttgctattacattctaaccACCTTATttttttct atttatGAGGTTATAGTGTAGTTATCaagaatgctaaacgggagtagataaaaatggc c" /listShort="adaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 203603 /Source="Nicolas_upshifts" /id="U126" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.994005994005994" /xcortree=376 /SigmaFactorBS="ttgttatcttgctattacattctaaccACCTTATttttttct atttatGAGGTTATAGTGTAGTTATCaagaatgctaaacgggagtagataaaaatggc c" /listShort="adaA" /GFF_Attribute="listLong" CDS 203729..204364 /gene="adaA" /locus_tag="BSU_01810" /old_locus_tag="BSU01810" /EC_number="2.1.1.63" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1744039, 2120677, 7565865, 8376346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744039, 2120677, 7565865, 8376346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylphosphotriester-DNA alkyltransferase and transcriptional regulator (AraC/XylS family)" /protein_id="NP_388062.1" /db_xref="EnsemblGenomes-Gn:BSU01810" /db_xref="EnsemblGenomes-Tr:CAB11957" /db_xref="GOA:P19219" /db_xref="InterPro:IPR004026" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR016220" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR035451" /db_xref="SubtiList:BG10166" /db_xref="UniProtKB/Swiss-Prot:P19219" /translation="MPDSINNGHKESHDHRISNDAEMITDEKWQAIINNDAAYNNQFF YAVKSTGIFCKPSCKSRVPKKENVCIFPNTEQALRANFRPCKRCKPTNEKMPDSEWVD LITEYIDKNFTEKLTLESLADICHGSPYHMHRTFKKIKGITLVEYIQQVRVHAAKKYL IQTNKAIGDIAICVGIANAPYFITLFKKKTGQTPARFRQMSKMEETYNGNK*" gene 203729..204364 /gene="adaA" /locus_tag="BSU_01810" /old_locus_tag="BSU01810" CDS 204351..204890 /gene="adaB" /locus_tag="BSU_01820" /old_locus_tag="BSU01820" /EC_number="2.1.1.63" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1744039, 2120677, 7565865, 8376346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744039, 2120677, 7565865, 8376346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O6-methylguanine-DNA methyltransferase; prophage1 region" /protein_id="NP_388063.1" /db_xref="EnsemblGenomes-Gn:BSU01820" /db_xref="EnsemblGenomes-Tr:CAB11958" /db_xref="GOA:P19220" /db_xref="InterPro:IPR001497" /db_xref="InterPro:IPR008332" /db_xref="InterPro:IPR014048" /db_xref="InterPro:IPR036217" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036631" /db_xref="SubtiList:BG10167" /db_xref="UniProtKB/Swiss-Prot:P19220" /translation="METNKPTLYWSLLMFKDWNFYIASTLKGLVFVGSQNKPIEELFE WARKRFPGSLLVEDDDKLEPYAVEITQYLEGKRKNFTVPVEYAGTQFQLAVWNALCEI PYGQTKSYSDIANDINKPAAVRAVGAAIGANPVLITVPCHRVIGKNGSLTGYRGGFEM KTLLLDLEKRASSEMDVPH*" gene 204351..204890 /gene="adaB" /locus_tag="BSU_01820" /old_locus_tag="BSU01820" S_feature 204891..204975 /Source="Nicolas_S_feature" /locus_tag="new_204891_204975" /HighExp="Sw, BC, S8, S6, S7, S3, G135, S4, G180, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.77593299999999998" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S71" promotor_-35 204954..204961 /Source="Nicolas_upshift_promotors" /id="U127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.886113886113886" /psig="0.976023976023976" /xcortree=2989 /SigmaFactorBS="ttcttttagaggaaagtaaagaccagtttactgataaACTTG ACAacttttaaaatttaGCATATCTTATACGTAACTTaataatcgatgcagatgttta t" /listShort="S72, S73, ndhF, ybcC, S74, ybcF, ybcH, ybcI, S75, ybzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 204976..204995 /Source="Nicolas_upshift_promotors" /id="U127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.886113886113886" /psig="0.976023976023976" /xcortree=2989 /SigmaFactorBS="ttcttttagaggaaagtaaagaccagtttactgataaACTTG ACAacttttaaaatttaGCATATCTTATACGTAACTTaataatcgatgcagatgttta t" /listShort="S72, S73, ndhF, ybcC, S74, ybcF, ybcH, ybcI, S75, ybzH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 204977..205210 /Source="Nicolas_S_feature" /locus_tag="new_204977_205210" /HighExp="HiOs, Heat, HiTm, MG 150, dia15, MG-0.2, Lbtran, GM-0.2, M9-stat, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.976" /TUlongSig="NA" /TUlongPSig="NA" /label="S72" upshifts 204977 /Source="Nicolas_upshifts" /id="U127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.886113886113886" /psig="0.976023976023976" /xcortree=2989 /SigmaFactorBS="ttcttttagaggaaagtaaagaccagtttactgataaACTTG ACAacttttaaaatttaGCATATCTTATACGTAACTTaataatcgatgcagatgttta t" /listShort="S72, S73, ndhF, ybcC, S74, ybcF, ybcH, ybcI, S75, ybzH" /GFF_Attribute="listLong" downshifts 205167 /Source="Nicolas_upshifts" /id="D66" /incds=0 /nref=60 /ntot=223 /MaxReadThrough="6.74927" /MaxDrop="5.18296" /score="13.5044076" /energy="-17.5" /TU="U127" /idTUdmin="U126" /TUdmin=1344 /isTUend="FALSE" S_feature 205212..205408 /Source="Nicolas_S_feature" /locus_tag="new_205212_205408" /HighExp="Heat, G135, G180, UNK1, S8, C30, Gly, GM-0.2, G150, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.976" /TUlongSig="NA" /TUlongPSig="NA" /label="S73" CDS 205409..206926 /gene="ndhF" /locus_tag="BSU_01830" /old_locus_tag="BSU01830" /EC_number="1.6.-.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10658656, 15849754, 16850406, 17015645, 6816592, 7565865; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative NADH dehydrogenase; prophage 1 region" /protein_id="NP_388064.1" /db_xref="EnsemblGenomes-Gn:BSU01830" /db_xref="EnsemblGenomes-Tr:CAB11959" /db_xref="GOA:P39755" /db_xref="InterPro:IPR001516" /db_xref="InterPro:IPR001750" /db_xref="SubtiList:BG10949" /db_xref="UniProtKB/Swiss-Prot:P39755" /translation="MLVSLSLSSLLTLFFIMLMASGISGLLFLHPRVPLSFVRIHIGI LALPLLVSLLILANSGVSGNVGPWHLDSLACLMTFFVLAIGFIIQRFSVRYLMGDRSY RKYFTLFTFTTGAASMTWLSGDLRLMVLFWGATLVGLTLLIRLNSAWQVASEAAKISG RLFLLSWFSLFFAMMWLFHATGQWQLSLVVTNESLAGLGEWERTGIQLLIVLAVIIPA AQWPFQRWLVESIVAPTPVSAIMHAGLVNAGGIILTRFSPLFHGGIASIILLLLASIS VLIGTGISLVQVDYKRQLVGSTIGQMGFMLIQCALGAYIAAIIHLILHGLFKATLFLQ AGSAVGRHEVSTRTNERTSYLWVMAGRILSLVIGVAFWLTAPGDGYHLISALILGWSL SVSWDQLVAFGEGRIGRIAGLTVLGGAALVYFIIHHLFYKWLHTTIFQSVQPPMSAVM IVVCLLLFGSALGTWVARHRSSVFFAVLYLWLVRLGEAKPKSVESHPDYLKQYIS*" gene 205409..206926 /gene="ndhF" /locus_tag="BSU_01830" /old_locus_tag="BSU01830" CDS 206941..209556 /gene="ybcC" /locus_tag="BSU_01845" /old_locus_tag="BSU01845" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="conserved transmembrane protein coupled to NADH-ubiquinone oxidoreductase chain 5 homolog; prophage 1 region" /protein_id="NP_388065.2" /db_xref="EnsemblGenomes-Gn:BSU01845" /db_xref="EnsemblGenomes-Tr:CAB11960" /db_xref="InterPro:IPR018752" /db_xref="SubtiList:BG12706" /db_xref="UniProtKB/Swiss-Prot:O34688" /translation="MGITSVLTKDNVKKIDTDIDVQERDLNVFITSASRVIAPLWPIS TFAARNPWMGLENQPFDQVASWLKNTRDVDIYPSASMIRSAKNKGEIDEDFVEMGLQR WLDSHSYHIPRDVAERFCHAALKLDPLPSDLLSSHELEKLVSECSGLDHIENVFMQPL SSYIENQDGERLVNILDHHVIKWSKLYLDDSQAGWTMPNREEGFYRAWQHLIQYDPAL SKKQRERVKGWPKEAHLALQEALFALEIPESEIQTYLEGHLLSLPGWAGMMLWRSQQS SHEHALLTEYLAVRISMEWALIKPYLPLTNERSKKTISIAPLIAAWIHWGGLTLEEWS QMTASEQNEYLSFAYSFDEKLRKKLWLEAWEQTYTDRLSQKIISKQRETGREKSALAQ LAFCIDVRSEPFRRQLEKEGPFETIGIAGFFGVPIATCELGSKHSHASLPIIQKPQNK IKEFADEDVFKKYNQRKQAIHSLSHTFKTMKQNALSSLLLPELSGPWLTLQMAARSFV PRKAGRFIRNLREAWLRKPDTKLSLHHDATEAEIPVGFTDEEKVNYARQALKMMGLTE NIAPLVVICGHGSQSTNNPYSAALDCGACGGAAGGFNARVLAALCNLSEVREALLAEG IKIPEDTVFAAAEHNTTVDELHWLYVPELSEAAQEAFEQIEAVMPKVRHHVNAERLAQ LPNFQSKLKNPKAEANRFAEDWSEIRPEWGLARNAAFIIGKRELTQDCDLEGRAFLHN YDWKQDESGELLANIIVGPGTVAQWINLQYYASTVAPHYYGSGNKATQTVTAGLGVMQ GNASDLLAGLPWQSVMESDHEAYHSPLRLLILIQAPREYVERLLNHDSAFLQKVQNGW VRLASLDPEGCWESW*" gene 206941..209556 /gene="ybcC" /locus_tag="BSU_01845" /old_locus_tag="BSU01845" S_feature 209557..209632 /Source="Nicolas_S_feature" /locus_tag="new_209557_209632" /HighExp="Heat, G180, G135, C30, GM-0.2, UNK1, GM-0.1, BMM, G150, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.976" /TUlongSig="NA" /TUlongPSig="NA" /label="S74" CDS 209633..210160 /gene="ybcF" /locus_tag="BSU_01860" /old_locus_tag="BSU01860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme; prophage 1 region" /protein_id="NP_388067.1" /db_xref="EnsemblGenomes-Gn:BSU01860" /db_xref="EnsemblGenomes-Tr:CAB11962" /db_xref="GOA:O34823" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG12708" /db_xref="UniProtKB/Swiss-Prot:O34823" /translation="MNVNQNKKVLFLTDIENGLEPILQEATNTSAENMLTIQSYGASI SHPYGEIMRSVIFAIYQEDVEEIFVVGTKDKKTSAGNGLTQLETMKDKIQTLDYLFQN CKPEFLGGTVDEWLNENSSDTIEKSVDMIRHHPLVPSYVKVRGLFVNHKGGKPSIAEV PDVKTGQAMPDHCLS*" gene 209633..210160 /gene="ybcF" /locus_tag="BSU_01860" /old_locus_tag="BSU01860" CDS 210224..210514 /gene="ybcH" /locus_tag="BSU_01870" /old_locus_tag="BSU01870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function; prophage 1 region" /protein_id="NP_388068.1" /db_xref="EnsemblGenomes-Gn:BSU01870" /db_xref="EnsemblGenomes-Tr:CAB11963" /db_xref="SubtiList:BG12709" /db_xref="UniProtKB/Swiss-Prot:O34795" /translation="MSANLTDFVTKTIEEMNSFDRENMECIKKLIRKAIDFYHLKSYE EVEETHSGNVRFLHVHSMMEENMLSKMIVVTRNGKTDLDIEGVYEGYVVREY*" gene 210224..210514 /gene="ybcH" /locus_tag="BSU_01870" /old_locus_tag="BSU01870" CDS 210572..210946 /gene="ybcI" /locus_tag="BSU_01880" /old_locus_tag="BSU01880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; prophage 1 region" /protein_id="NP_388069.1" /db_xref="EnsemblGenomes-Gn:BSU01880" /db_xref="EnsemblGenomes-Tr:CAB11964" /db_xref="InterPro:IPR018745" /db_xref="SubtiList:BG12710" /db_xref="UniProtKB/Swiss-Prot:O34380" /translation="MKKSKGSIESEISKSITQWEKDYLGRGSVSVKTDILRDMIIVNL KGILTPAEYVVCGSKEGMLSIKQTRSELVESGIEGLKDIILKITGEKVKSFHTDLSSR TGERVMVFKLCNDLEKNLEKIL*" gene 210572..210946 /gene="ybcI" /locus_tag="BSU_01880" /old_locus_tag="BSU01880" S_feature 210947..211412 /Source="Nicolas_S_feature" /locus_tag="new_210947_211412" /HighExp="Heat, G135, G180, C30, S8, Etha, S7, GM-0.1, GM-0.2, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.976" /TUlongSig="NA" /TUlongPSig="NA" /label="S75" promotor_-10 complement(211327..211345) /Source="Nicolas_upshift_promotors" /id="U128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=214 /SigmaFactorBS="aatccgttttttggatatatttaattaaaGGTTTATctctga ctaattccGTGAAATGAAACTGAAGACagcatatcaattttgttcaccgcttaaattt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(211335) /Source="Nicolas_upshifts" /id="U128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=214 /SigmaFactorBS="aatccgttttttggatatatttaattaaaGGTTTATctctga ctaattccGTGAAATGAAACTGAAGACagcatatcaattttgttcaccgcttaaattt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(211360..211366) /Source="Nicolas_upshift_promotors" /id="U128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=214 /SigmaFactorBS="aatccgttttttggatatatttaattaaaGGTTTATctctga ctaattccGTGAAATGAAACTGAAGACagcatatcaattttgttcaccgcttaaattt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 211393..211400 /Source="Nicolas_upshift_promotors" /id="U129" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=2370 /SigmaFactorBS="tcagagataaacctttaattaaatatatccaaaaaacggATT GACATatcgaaatataaCGATATAATAATCGATATGGaaccaattgaagtattcaaag c" /listShort="ybzH, S76, ybcL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 211413..211432 /Source="Nicolas_upshift_promotors" /id="U129" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=2370 /SigmaFactorBS="tcagagataaacctttaattaaatatatccaaaaaacggATT GACATatcgaaatataaCGATATAATAATCGATATGGaaccaattgaagtattcaaag c" /listShort="ybzH, S76, ybcL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 211414 /Source="Nicolas_upshifts" /id="U129" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=2370 /SigmaFactorBS="tcagagataaacctttaattaaatatatccaaaaaacggATT GACATatcgaaatataaCGATATAATAATCGATATGGaaccaattgaagtattcaaag c" /listShort="ybzH, S76, ybcL" /GFF_Attribute="listLong" CDS 211429..211731 /gene="ybzH" /locus_tag="BSU_01889" /old_locus_tag="BSU01889" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (ArsR family); prophage 1 region" /protein_id="YP_003097670.1" /db_xref="EnsemblGenomes-Gn:BSU01889" /db_xref="EnsemblGenomes-Tr:CAX52540" /db_xref="GOA:C0H3S9" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3S9" /translation="MEPIEVFKALSNESRLQILQWLKEPDRHFAPHEGIDMNTIGVCV SQITDKLKMTQSTASQYLTILLRAGLIKAERIGKYTYYKRDEEAIGKLADFLKTEI*" gene 211429..211731 /gene="ybzH" /locus_tag="BSU_01889" /old_locus_tag="BSU01889" downshifts 211724 /Source="Nicolas_upshifts" /id="D67" /incds=0 /nref=175 /ntot=256 /MaxReadThrough="5.31372" /MaxDrop="5.98354" /score="13.6598797" /energy="-10.8" /TU="U129" /idTUdmin="U127" /TUdmin=25 /isTUend="FALSE" S_feature 211769..211858 /Source="Nicolas_S_feature" /locus_tag="new_211769_211858" /HighExp="dia5, Diami, C30, Heat, dia15, T2.0H, S8, S1, Cold, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S76" CDS 211859..213031 /gene="ybcL" /locus_tag="BSU_01890" /old_locus_tag="BSU01890" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15812018, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter; prophage 1 region" /protein_id="NP_388070.1" /db_xref="EnsemblGenomes-Gn:BSU01890" /db_xref="EnsemblGenomes-Tr:CAB11965" /db_xref="GOA:O34663" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12711" /db_xref="UniProtKB/Swiss-Prot:O34663" /translation="MSNTWKIYILAIVSFLVGTSEYIISGILDQIAHTLGITLAAAGQ LITIFSLVYALSTPVLMALTASMDRRKLMMYALGLFVFGNVLAFVLPGYGWFIAARII MAMGAGVVVVTALTIAAKIASEGKQGSAIATVVMGFTASLIIGVPLGRMIAVALGWKS VFGAIALLGLIAMVVIFFTLPYTEGDKPVPLLQQLALFKKRKVAMGLSITFFWLGGYS VAYTYLSPYLLNISGINGKLLSGVLLIFGIASLVGSKFGGYSTDKWGVPFTLVGGMTL HIVTLILLSLVTHSYIGVLVILILWSFAAWSTGPTQQFHLATIEPEMSGVLLSMNQSM MQFAMAVGAGIGGVFVENVSLASITWVGALGVMIAIIASLLIFNSQPKQALKDINQ*" gene 211859..213031 /gene="ybcL" /locus_tag="BSU_01890" /old_locus_tag="BSU01890" promotor_-35 212376..212383 /Source="Nicolas_upshift_promotors" /id="U130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.541458541458541" /psig="0.978021978021978" /xcortree=2180 /SigmaFactorBS="atttggagccattgctttgttgggattgatcgcaaTGGTCGT TattttctttactcTTCCGTATACTGAAGGGGATaagcctgtgcctttgcttcaacag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 212397..212416 /Source="Nicolas_upshift_promotors" /id="U130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.541458541458541" /psig="0.978021978021978" /xcortree=2180 /SigmaFactorBS="atttggagccattgctttgttgggattgatcgcaaTGGTCGT TattttctttactcTTCCGTATACTGAAGGGGATaagcctgtgcctttgcttcaacag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 212401 /Source="Nicolas_upshifts" /id="U130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.541458541458541" /psig="0.978021978021978" /xcortree=2180 /SigmaFactorBS="atttggagccattgctttgttgggattgatcgcaaTGGTCGT TattttctttactcTTCCGTATACTGAAGGGGATaagcctgtgcctttgcttcaacag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 213016 /Source="Nicolas_upshifts" /id="D68" /incds=0 /nref=8 /ntot=59 /MaxReadThrough="0.16425" /MaxDrop="4.4712" /score="19.9212489" /energy="-11" /TU="NA" /idTUdmin="U129" /TUdmin="-3" /isTUend="TRUE" CDS 213155..213469 /gene="ybcM" /locus_tag="BSU_01900" /old_locus_tag="BSU01900" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388071.1" /db_xref="EnsemblGenomes-Gn:BSU01900" /db_xref="EnsemblGenomes-Tr:CAB11983" /db_xref="GOA:O31421" /db_xref="SubtiList:BG12712" /db_xref="UniProtKB/Swiss-Prot:O31421" /translation="MRFLKALPRRAEVQYDCLDRTLETQENVNLNIRVNVKEVATWGV NTCIISLKGLDNADDRFVLPEVNTALALFPLSIAADCLLMLPCISVVMSISSVMKSVT VE*" gene 213155..213469 /gene="ybcM" /locus_tag="BSU_01900" /old_locus_tag="BSU01900" misc_feature 213273..213274 /Source="Nicolas_upshift_promotors" /id="U131" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.908091908091908" /psig="0.014985014985015" /xcortree=18 /SigmaFactorBS="aacacaagagaacgtaaacctgaacatccgcgtaaacgtcaa ggaagttgCCacttggggagtaaacacttgcatcatctcgctgaaaggcctagacaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 213283 /Source="Nicolas_upshifts" /id="U131" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.908091908091908" /psig="0.014985014985015" /xcortree=18 /SigmaFactorBS="aacacaagagaacgtaaacctgaacatccgcgtaaacgtcaa ggaagttgCCacttggggagtaaacacttgcatcatctcgctgaaaggcctagacaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 213349 /Source="Nicolas_upshifts" /id="D69" /incds=1 /nref=5 /ntot=15 /MaxReadThrough="0.469730000000001" /MaxDrop="5.4933" /score="-8.96893905" /energy="-9.8" /TU="NA" /idTUdmin="U131" /TUdmin=0 /isTUend="TRUE" promotor_-35 213850..213857 /Source="Nicolas_upshift_promotors" /id="U132" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig="0.984015984015984" /xcortree=479 /SigmaFactorBS="atactaattaatgtaatttttaggataatatacaaaatccCC CTTACTtcgacaattgcaaTCTGGTATTATCGTATCGCAtgggagctatgtcaataga c" /listShort="S77, skfA, skfB, skfC, skfE, skfF, skfG, skfH, S78, S79, ybdG, ybdJ, ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 213870 /Source="Nicolas_upshifts" /id="U132" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig="0.984015984015984" /xcortree=479 /SigmaFactorBS="atactaattaatgtaatttttaggataatatacaaaatccCC CTTACTtcgacaattgcaaTCTGGTATTATCGTATCGCAtgggagctatgtcaataga c" /listShort="S77, skfA, skfB, skfC, skfE, skfF, skfG, skfH, S78, S79, ybdG, ybdJ, ybdK, ybzI" /GFF_Attribute="listLong" promotor_-10 213871..213890 /Source="Nicolas_upshift_promotors" /id="U132" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig="0.984015984015984" /xcortree=479 /SigmaFactorBS="atactaattaatgtaatttttaggataatatacaaaatccCC CTTACTtcgacaattgcaaTCTGGTATTATCGTATCGCAtgggagctatgtcaataga c" /listShort="S77, skfA, skfB, skfC, skfE, skfF, skfG, skfH, S78, S79, ybdG, ybdJ, ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 213878..213940 /Source="Nicolas_S_feature" /locus_tag="new_213878_213940" /HighExp="M9-stat, T5.0H, T3.0H, T2.30H, T4.0H, T3.30H, T1.30H, T1.0H, T0.0H, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.984" /TUlongSig="NA" /TUlongPSig="NA" /label="S77" CDS 213941..214108 /gene="skfA" /locus_tag="BSU_01910" /old_locus_tag="BSU01910" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15812018, 16816204, 17069462, 17184776, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15812018, 16816204, 17069462, 17184776, 26284661; Product type f: factor" /codon_start=1 /transl_table=11 /product="sporulation killing factor A" /protein_id="NP_388072.1" /db_xref="EnsemblGenomes-Gn:BSU01910" /db_xref="EnsemblGenomes-Tr:CAB11984" /db_xref="GOA:O31422" /db_xref="InterPro:IPR030919" /db_xref="SubtiList:BG12713" /db_xref="UniProtKB/Swiss-Prot:O31422" /translation="MKRNQKEWESVSKKGLMKPGGTSIVKAAGCMGCWASKSIAMTRV CALPHPAMRAI*" gene 213941..214108 /gene="skfA" /locus_tag="BSU_01910" /old_locus_tag="BSU01910" downshifts complement(213954) /Source="Nicolas_upshifts" /id="D70" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="0.99059" /MaxDrop="3.89647" /score="2.42246888" /energy="-3.5" /TU="NA" /idTUdmin="U134" /TUdmin=2289 /isTUend="FALSE" downshifts 214098 /Source="Nicolas_upshifts" /id="D71" /incds=0 /nref=24 /ntot=172 /MaxReadThrough="8.08284" /MaxDrop="7.24265" /score="-7.12226565" /energy="-13" /TU="U132" /idTUdmin="U131" /TUdmin=749 /isTUend="FALSE" CDS 214175..215407 /gene="skfB" /locus_tag="BSU_01920" /old_locus_tag="BSU01920" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15812018, 16816204, 17069462, 17184776, 18307109, 23282011, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15812018, 16816204, 17069462, 17184776, 18307109, 23282011, 26284661; Product type f: factor" /codon_start=1 /transl_table=11 /product="synthesis of sporulation killing factor A" /protein_id="NP_388073.2" /db_xref="EnsemblGenomes-Gn:BSU01920" /db_xref="EnsemblGenomes-Tr:CAB11985" /db_xref="GOA:O31423" /db_xref="InterPro:IPR000385" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023885" /db_xref="InterPro:IPR030915" /db_xref="InterPro:IPR034395" /db_xref="InterPro:IPR034481" /db_xref="SubtiList:BG12714" /db_xref="UniProtKB/Swiss-Prot:O31423" /translation="MSYDRVKDFDLPELAVHLQPHGAVMIDRKSMFYFRLSGRGAQLA FLLSKNKNLHKTARIWEIMKKEEMSADQLKEELSAHPFTEAWTEGLLDQPLHVSGSLD SYLPISCTLQLTNACNLSCSFCYASSGKPYPEELSSEQWILVMQKLAAHGVADITLTG GEAKLIKGFKELVVVASSLFTNVNVFSNGLNWRDEEVELLSHLGNVSVQISIDGMDNT HDQLRGRKGGFKESMNTIKKLSEANIPVIVAMTINESNADEVSDVVEQCANAGAFIFR AGKTLSVGRATEGFKALDIDFEEMVQIQLREARHKWGDRLNIIDWEHEESSFTTDFCT PGYLAWYIRADGYVTPCQLEDLPLGHILEDSMADIGSPARLLQLKCEAKNCKCIGKIE LSEPDLPFQKEVKAGIQE*" gene 214175..215407 /gene="skfB" /locus_tag="BSU_01920" /old_locus_tag="BSU01920" CDS 215404..216894 /gene="skfC" /locus_tag="BSU_01935" /old_locus_tag="BSU01935" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15812018, 15849754, 16816204, 16850406, 17069462, 17184776, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15812018, 15849754, 16816204, 16850406, 17069462, 17184776, 26284661; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sporulation killing factor biosynthesis and export" /protein_id="YP_003097671.1" /db_xref="EnsemblGenomes-Gn:BSU01935" /db_xref="EnsemblGenomes-Tr:CAX52541" /db_xref="GOA:O31425" /db_xref="InterPro:IPR003675" /db_xref="UniProtKB/Swiss-Prot:O31425" /translation="MNSLSLVFWSILAVVGLLLFIKFKPPTIASLLLSKDEAKEISIQ FIKEFVGIDVENWDFYSVYWYDHDTVNKLHHLGILKKNRKVLYDVGLVESWRVRFVHQ NQSFVVGVNANREITFFYADVPKKTLSGKFEQVSPETLKQRLMASPDGLWSRANMTGT GKKEEDFREVSTYWYIAEAGDIRLKVTVELQGGRISYIGTEQEILTDQMSKVIRDEQV ESTFGVSGMLGSALAMILAILILVFMDVQTSIIFSLVLGLLIIICQSLTLKEDIQLTI VNAYDARMSVKTVSLLGILSTLLTGLLTGFVVFICSLAGNALAGDFGWKTFEQPIVQI FYGIGAGLISLGVTSLLFNLLEKKQYLRISPELSNRTVFLSGFTFRQGLNMSIQSSIG EEVIYRLLMIPVIWWMSGNILISIIVSSFLWAVMHQVTGYDPRWIRWLHLFIFGCFLG VLFIKFGFICVLVAHFIHNLVLVCMPLWQFKLQKHMHHDQPKHTSL*" gene 215404..216894 /gene="skfC" /locus_tag="BSU_01935" /old_locus_tag="BSU01935" promotor_-35 216301..216309 /Source="Nicolas_upshift_promotors" /id="U133" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=434 /SigmaFactorBS="caaaacggtcagtttattaggtattttgtctacacttcttAC AGGATTAttaacaggattTGTAGTATTTATATGTTCAttggcaggaaatgcgcttgct g" /listShort="skfE, skfF, skfG, skfH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(216318..216337) /Source="Nicolas_upshift_promotors" /id="U134" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1365 /SigmaFactorBS="gttgttcaaacgttttccatccaaaatcaccaGCAAGCGCAT ttcctgccaatgAACATATAAATACTACAAATcctgttaataatcctgtaagaagtgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 216321..216339 /Source="Nicolas_upshift_promotors" /id="U133" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=434 /SigmaFactorBS="caaaacggtcagtttattaggtattttgtctacacttcttAC AGGATTAttaacaggattTGTAGTATTTATATGTTCAttggcaggaaatgcgcttgct g" /listShort="skfE, skfF, skfG, skfH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 216321 /Source="Nicolas_upshifts" /id="U133" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=434 /SigmaFactorBS="caaaacggtcagtttattaggtattttgtctacacttcttAC AGGATTAttaacaggattTGTAGTATTTATATGTTCAttggcaggaaatgcgcttgct g" /listShort="skfE, skfF, skfG, skfH" /GFF_Attribute="listLong" upshifts complement(216331) /Source="Nicolas_upshifts" /id="U134" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1365 /SigmaFactorBS="gttgttcaaacgttttccatccaaaatcaccaGCAAGCGCAT ttcctgccaatgAACATATAAATACTACAAATcctgttaataatcctgtaagaagtgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(216350..216359) /Source="Nicolas_upshift_promotors" /id="U134" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1365 /SigmaFactorBS="gttgttcaaacgttttccatccaaaatcaccaGCAAGCGCAT ttcctgccaatgAACATATAAATACTACAAATcctgttaataatcctgtaagaagtgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 216913..217632 /gene="skfE" /locus_tag="BSU_01950" /old_locus_tag="BSU01950" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26284661; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sporulation killing factor biosynthesis and export; ABC transporter (binding protein)" /protein_id="NP_388077.1" /db_xref="EnsemblGenomes-Gn:BSU01950" /db_xref="EnsemblGenomes-Tr:CAB11989" /db_xref="GOA:O31427" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12718" /db_xref="UniProtKB/Swiss-Prot:O31427" /translation="MQLMQVQNLSKCYRNGDGVEHLSFSIQRGEIVALLGPNGAGKTT TIRCLTGLYKPDKGDILIEGSPPGDINVQKKVALIPDQPYLYPALTAAEHIQFRARGY HPGKKDVKERVYHALKEVHLEEKANQLCGQLSRGQKQRVVLAGAIVQDALLYILDEPT VGLDIPSKQWLSNWLKTKTDQGCSAFVSTHSLEFVIETADRVILIRDGKLMQDLYVPQ FEEQAEWRKEVIRLLGEWSDE*" gene 216913..217632 /gene="skfE" /locus_tag="BSU_01950" /old_locus_tag="BSU01950" CDS 217697..219040 /gene="skfF" /locus_tag="BSU_01960" /old_locus_tag="BSU01960" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15812018, 15849754, 16816204, 16850406, 17069462, 17184776, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15812018, 15849754, 16816204, 16850406, 17069462, 17184776, 26284661; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sporulation killing factor biosynthesis and export; ABC transporter (permease)" /protein_id="NP_388078.2" /db_xref="EnsemblGenomes-Gn:BSU01960" /db_xref="EnsemblGenomes-Tr:CAB11990" /db_xref="GOA:O31428" /db_xref="InterPro:IPR030920" /db_xref="SubtiList:BG12719" /db_xref="UniProtKB/Swiss-Prot:O31428" /translation="MPFLIMLLFVGAIGFQVSFVSRSTTWDMSIAGWVLTGVFILYTA FGLFSNRLPSQMADIIWLYGTATSFSKVVYSVLFFSVTWKALLWIISAIFGDVLIVLL SGDHINLLGRSIIFVGLFFIAEVWLMSVSCARTVKKMKRVYVLVFLLMLGIYSICLYR FFFLQHSSGIWESIARFISGVGLVFDTLSPLYVVVFIGIITVSFMTIAFTSRQVEMKE SLVKEAEFWEEFQERQFGSGQIIQKPKTTWWGLQGLNGIWSFLWLELLLFKKYLFFHS IHTVMLSGVFYVVIFMYPEWFYLLFFLIVSAVMLSSYYSGIVRHSQSGTLHLFPGALW KKIIILELTNTVWLYILYCVSITFMAVGNLVYWYIYGLGIYIWFMTIRLFAFTHTNRN DIKLSLPQYYKSFFMALGLSGICLYVIHLLTADWYTLVVVVCIGSLSWCLFYRFR*" gene 217697..219040 /gene="skfF" /locus_tag="BSU_01960" /old_locus_tag="BSU01960" CDS 219087..219602 /gene="skfG" /locus_tag="BSU_01970" /old_locus_tag="BSU01970" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15812018, 16816204, 17069462, 17184776, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15812018, 16816204, 17069462, 17184776, 26284661; Product type ph : phenotype" /codon_start=1 /transl_table=11 /product="sporulation killing factor biosynthesis and export" /protein_id="NP_388079.2" /db_xref="EnsemblGenomes-Gn:BSU01970" /db_xref="EnsemblGenomes-Tr:CAB11991" /db_xref="GOA:O31429" /db_xref="InterPro:IPR016024" /db_xref="SubtiList:BG12720" /db_xref="UniProtKB/Swiss-Prot:O31429" /translation="MNSNGDKLSLSVQNLANTNEITIVQAIGELKKSGKDAIPVLVEA LKEEGSLCNIAAAVLGEFGEDASEAAEELSCLLKSHAEDTRMAAAISLMRIGKPSLPF VIKIAQESEGQSCFWASWCIAWIDPSCIEPKMYKCLKYEHEHPSGIVAPFAAEEALGK LIAFQLKDKED*" gene 219087..219602 /gene="skfG" /locus_tag="BSU_01970" /old_locus_tag="BSU01970" CDS 219607..220032 /gene="skfH" /locus_tag="BSU_01980" /old_locus_tag="BSU01980" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15812018, 16816204, 17069462, 17184776, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15812018, 16816204, 17069462, 17184776, 26284661; Product type ph : phenotype" /codon_start=1 /transl_table=11 /product="sibling killing effect; sporulation killing factor biosynthesis and export" /protein_id="NP_388080.2" /db_xref="EnsemblGenomes-Gn:BSU01980" /db_xref="EnsemblGenomes-Tr:CAB11992" /db_xref="GOA:O31430" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12721" /db_xref="UniProtKB/Swiss-Prot:O31430" /translation="MKDEQMLTEWPSHLPWLNQSQNDFTFPSDTYLLLYFWSMSCPNC HQLTDKVLQDIKDMNVKVIGVHVPYIEEEKSMEVVLTYALDRGLAIPIVLDQNYEIVT TCHVQGIPSFCLLSQYGQIITKTMGDVGWDKMLKKIAGL*" gene 219607..220032 /gene="skfH" /locus_tag="BSU_01980" /old_locus_tag="BSU01980" S_feature 220033..220103 /Source="Nicolas_S_feature" /locus_tag="new_220033_220103" /HighExp="T4.0H, T5.0H, Pyr, T3.30H, S2, G/S, LoTm, T3.0H, M9-stat, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.984" /TUlongSig="NA" /TUlongPSig="NA" /label="S78" downshifts 220060 /Source="Nicolas_upshifts" /id="D72" /incds=0 /nref=22 /ntot=127 /MaxReadThrough="4.07672" /MaxDrop="3.58139" /score="5.89945455" /energy="-8.8" /TU="U132" /idTUdmin="U133" /TUdmin=0 /isTUend="TRUE" S_feature 220105..220278 /Source="Nicolas_S_feature" /locus_tag="new_220105_220278" /HighExp="LoTm, T5.0H, T4.0H, T3.30H, Pyr, T-2.40H, T3.0H, T-5.40H, S2, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.984" /TUlongSig="NA" /TUlongPSig="NA" /label="S79" CDS 220279..221256 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase/transferase" /protein_id="NP_388081.2" /db_xref="EnsemblGenomes-Gn:BSU01990" /db_xref="EnsemblGenomes-Tr:CAB11993" /db_xref="GOA:O31431" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12722" /db_xref="UniProtKB/Swiss-Prot:O31431" /translation="MKTLWKVLKIVFVSLAALVLLVSVSVFIYHHFQLNKEAALLKGK GTVVDVDGKKMNVYQEGSGKDTFVFMSGSGIAAPAYEMKGLYSKFSKENKIAVVDRAG YGYSEVSHDDRDIDTVLEQTRKALMKSGNKPPYILMPHSISGIEAMYWAQKYPKEIKA IIAMDIGLPQQYVTYKLSGVDRLKVRGFHLLTSIGFHRFIPSAVYNPEVIRQSFLTDE EKEIYKAINFKQFFNADMEHELLQSYQNGSKSVNLPAPKETPVLILDAVSDQNRHSKY AIQNRKDYEAFAAQFNTADIKELRGTHSIYLYQPDQIYKLSMEFMRKVR*" gene 220279..221256 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" CDS 221258..221929 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component system response regulator [YbdK]" /protein_id="NP_388082.1" /db_xref="EnsemblGenomes-Gn:BSU02000" /db_xref="EnsemblGenomes-Tr:CAB11994" /db_xref="GOA:O31432" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12723" /db_xref="UniProtKB/Swiss-Prot:O31432" /translation="MKGYRILIVEDDVMIGDLLQKILQREGYRVIWKTDGADVLSVIQ KVDLVIMDVMLPGEDGYQMSAKIKKLGLGIPVIFLSARNDMDSKLQGLQIGEDYMVKP FDPRELLLRMRNMLEHHYGTFTQIKHLYIDAVTKKVFNESLHDEVLFTAIERKIFFYL YENRDSILTKEHFFEYLWQLEDRNPNIVNVHIKKIRAKINDQAGEMIENIYGEGYRLN TVVKK*" gene 221258..221929 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" promotor_-35 221823..221829 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 221843..221862 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 221861 /Source="Nicolas_upshifts" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" CDS 221950..222912 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component system sensor histidine kinase [YbdJ]" /protein_id="NP_388083.1" /db_xref="EnsemblGenomes-Gn:BSU02010" /db_xref="EnsemblGenomes-Tr:CAB11995" /db_xref="GOA:O31433" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12724" /db_xref="UniProtKB/Swiss-Prot:O31433" /translation="MLLFTAVISVPMLLLAVSVLMSVIYDSMFKPMNHGMPFHRSFAY PAMIVVFLISLLLLAFLFSKSIHSLLHKINLLNQTIRHLASDQRVPDKIEVKRADEIG ELIKSVNLLIERTTYRELELRQQEEIKKELLQKLRHDINTPLTALRLQLFYLEDQCHG QAVFESLYQQIEYISELTNEFNLYSAETLESSYIVNEEVRLNELLETAVKKWDYLYSM SGIELHYKPADQDVIWMSNTLWMERLFDNIFQNTLRHSKAKKMEVTIEHGDVFIRDDG IGFDRNESSEGLGLKIIEDTCRLLAITYELHTNDNGTGFLFSKE*" gene 221950..222912 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" promotor_-35 222924..222926 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 222942..222961 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 222945 /Source="Nicolas_upshifts" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" CDS 222971..223234 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097672.1" /db_xref="EnsemblGenomes-Gn:BSU02019" /db_xref="EnsemblGenomes-Tr:CAX52542" /db_xref="UniProtKB/Swiss-Prot:C0H3T1" /translation="MNIICLKKSSKRLSTSQAVLVTDIADTGITAAAGADIIAATAAV RAKEDTTTVMAAVIVTNAGATAAVNPKKVLVPLLGQGFFYVTD*" gene 222971..223234 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" downshifts 223175 /Source="Nicolas_upshifts" /id="D73" /incds=0 /nref=120 /ntot=235 /MaxReadThrough="2.82444" /MaxDrop="4.652" /score="22.3698707" /energy="-12.1" /TU="U135" /idTUdmin="U136" /TUdmin="-6" /isTUend="TRUE" CDS complement(223219..223989) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" /EC_number="2.7.11.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21304896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative protein kinase" /protein_id="NP_388085.1" /db_xref="EnsemblGenomes-Gn:BSU02030" /db_xref="EnsemblGenomes-Tr:CAB11997" /db_xref="GOA:O31435" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG12726" /db_xref="UniProtKB/Swiss-Prot:O31435" /translation="MALKLLKKLLFDRPLKNGVILNHQYKIEECLGMGGYGLVYLCTD ILAQTPYVLKQLRPTKAKKEKEKVRFQQEIKLLKNIHHPQIPGFIDEFIIDGQAYYVM QFIEGENIEELLFFRKQPFTELMALQLISQLLEIIEYLHDRLIFHSDIRTPNIIINDG RLCLIDFGLAKQLTPEEMEEIKVRKQDDFFDLGETLLFLLYSQYKGKKKKNGTWLEEL TLTKEVTLLLKRLLGIEEEYQHTASIREDLNRAIQSVT*" gene complement(223219..223989) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" CDS complement(224075..224932) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16794953; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388086.1" /db_xref="EnsemblGenomes-Gn:BSU02040" /db_xref="EnsemblGenomes-Tr:CAB11998" /db_xref="SubtiList:BG12727" /db_xref="UniProtKB/Swiss-Prot:O31436" /translation="MVKKWLIQFAVMLSVLSTFTYSASAVGVTAITGNNSFDTAMPIG YWKYKNIDTTILEAGQDEAYFTFTANKGEKVYMRSTYQSAYTGMKIEIYDKNRIPVSQ GTEVINPNTFSSFIYANADAQNTTDTFYVKVSRGTYTGNMYFTLSIEDRIKSGSGTFQ FSGVAENKGNTSLSPSGSDSSVIKVDLTNQSGIPRDAIVTRVQTTATQTPSQGNTRHL IMTSENNEWSRALVNSSTSGSYDISLSDQLSVAKVWSFKYNTLATARSTMSNVKAKID YEYDVTKQF*" gene complement(224075..224932) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" downshifts complement(224097) /Source="Nicolas_upshifts" /id="D74" /incds=0 /nref=95 /ntot=184 /MaxReadThrough="1.56932" /MaxDrop="4.95806" /score="36.4950689" /energy="-11.9" /TU="NA" /idTUdmin="U137" /TUdmin="-4" /isTUend="TRUE" promotor_-10 complement(224146..224165) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(224179..224188) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(224181) /Source="Nicolas_upshifts" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(224945..224964) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(224970) /Source="Nicolas_upshifts" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" promotor_-35 complement(224979..224986) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 225000..225007 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-35" promotor_-10 225021..225039 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-10" upshifts 225023 /Source="Nicolas_upshifts" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" CDS 225064..226248 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388087.1" /db_xref="EnsemblGenomes-Gn:BSU02050" /db_xref="EnsemblGenomes-Tr:CAB11999" /db_xref="InterPro:IPR032617" /db_xref="SubtiList:BG12728" /db_xref="UniProtKB/Swiss-Prot:O31437" /translation="MRLNRQFIRTQLIAQNILSKNAPAKRENATENPAAVLEKAYSRL KSQSSTGGINQFNYSKTSVSGNSGTFSKVYQSANDRTVTDTGEETVIQSQNPYESESD IRIKILDEKYSRMNAINKTKSDPLGYIKDKYQNSKSPYFRSDLSAAERQAAYDNETEW LFKGKAQNYNLQDAVFRNVTFHGEVEAENEKVYQRGQVNQQLQVLLNRNHIHIPEGTE LTFTITPIDYQVRVSGTDDQDLIKQIEQVLQSGDNSKELFLHIMKSQSSDSAQFSEEA YKKYQAAREMYEVTGYHLKDLEVIDGRYVTPEGRDLMDVYKEELEKDPVQKQTASYAI SYYRSELSKIAEAGYNAIPDFILSIDYSNGSLRDVGQSKSYGTGDTGWLEALKRQTGV NY*" gene 225064..226248 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" downshifts 226234 /Source="Nicolas_upshifts" /id="D75" /incds=0 /nref=107 /ntot=207 /MaxReadThrough="2.98334" /MaxDrop="4.9582" /score="-3.87053033" /energy="-8.3" /TU="U139" /idTUdmin="U139" /TUdmin="-181" /isTUend="FALSE" promotor_-35 226402..226408 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 226422..226441 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 226436..226565 /Source="Nicolas_S_feature" /locus_tag="new_226436_226565" /HighExp="Glu, LoTm, M9-stat, G135, GM-0.2, T-0.40H, Fru, UNK1, MG 120, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD" /TUlongPSig=1 /label="S80" upshifts 226436 /Source="Nicolas_upshifts" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" CDS 226566..227954 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388088.1" /db_xref="EnsemblGenomes-Gn:BSU02060" /db_xref="EnsemblGenomes-Tr:CAB12000" /db_xref="GOA:P54425" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11505" /db_xref="UniProtKB/Swiss-Prot:P54425" /translation="MANKELKRGLGARHIQMIALGGTIGVGLFMGSASTISWTGPSVL LAYAICGIFIFFIMRAMGEMLYVEPSTGSFATFGHQYIHPMAGYITAWSNWFQWIIVG MSEIIAVGSYTKYWFPDLPAWIPGIVAMVILGAANLISVKSFGEFEFWFAMIKIVTII LMIIAGIGIIFFGFGNGGDAIGLSNLWSHGGFFAGGFSGFFFALSLVIAAYQGVELIG ITAGEAKDPQNTLRNAIQSIIWRILIFYIGAIFVIVTVYPWDELNSLGSPFVSTFSKI GITAAAGIINFVVITAAMSGCNSGIFSAGRMLYTLGVNGQAPKFFKKISRNGVPLYGT IAVLIGLAVGVVLNYIAPPKIFVYVYSASVLPGMIPWFIILISHIGFRKAKGAALDKH PFKMPFAPFTNYLTIAFLLMVLVGMWFNDDTRISLIVGVIFLALVVISYYVFGIGKRT QANLTKSEQAAE*" gene 226566..227954 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" downshifts 227962 /Source="Nicolas_upshifts" /id="D76" /incds=0 /nref=121 /ntot=219 /MaxReadThrough="2.32902" /MaxDrop="5.72049" /score="28.6554212" /energy="-8.5" /TU="NA" /idTUdmin="U140" /TUdmin="-15" /isTUend="TRUE" promotor_-35 228000..228006 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 228020..228031 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 228021 /Source="Nicolas_upshifts" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" CDS 228066..228314 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9016963" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9016963; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific SASP protein" /protein_id="NP_388089.1" /db_xref="EnsemblGenomes-Gn:BSU02070" /db_xref="EnsemblGenomes-Tr:CAB12001" /db_xref="GOA:P54379" /db_xref="InterPro:IPR020255" /db_xref="SubtiList:BG11504" /db_xref="UniProtKB/Swiss-Prot:P54379" /translation="MDVTLGYLRESLSNHLENEVCQRICKKMLAKRYANEEEFVKDLD DNEMSFLNHVLEKEIKYAQNEQDQKRAKELNEVYELLL*" gene 228066..228314 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" CDS 228331..228522 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388090.1" /db_xref="EnsemblGenomes-Gn:BSU02080" /db_xref="EnsemblGenomes-Tr:CAB12002" /db_xref="InterPro:IPR035314" /db_xref="SubtiList:BG11506" /db_xref="UniProtKB/Swiss-Prot:P54426" /translation="MGAIERSGYTFQPEFSVVRQNGAIHVYHQGEFVEEIEFEFNGEY PDHDLIEELVNHYCFEHEI*" gene 228331..228522 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" downshifts 228504 /Source="Nicolas_upshifts" /id="D77" /incds=0 /nref=17 /ntot=40 /MaxReadThrough="0.194030000000001" /MaxDrop="4.779" /score="29.4617878" /energy="-15.6" /TU="NA" /idTUdmin="U141" /TUdmin="-1" /isTUend="TRUE" CDS complement(228549..229352) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" /EC_number="3.5.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14742199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14742199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported beta-lactamase" /protein_id="NP_388091.1" /db_xref="EnsemblGenomes-Gn:BSU02090" /db_xref="EnsemblGenomes-Tr:CAB12003" /db_xref="GOA:P54427" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR002137" /db_xref="InterPro:IPR012338" /db_xref="PDB:5E2F" /db_xref="SubtiList:BG11507" /db_xref="UniProtKB/Swiss-Prot:P54427" /translation="MKKWIYVVLVLSIAGIGGFSVHAASSAHEKHLNVSKMNVDDEFK DTDGTFILHDLQKDQTFVYNRKRANQRQTPQSTFKVVNALIGLQVKAVRDEYDVKRWD GVKREFESWNRDHTLGSAMRESAIWYYQALARDIGEERMKTWLHTLSYGNEDISGGID QFWLQSSLTISPLEQETFLEKLAKEELPFDKPVMKIVKRMMIQEEGDHYTLYGKTGTR LTDMGLGWFVGFIKTEHGSYVFVTNVDDSGTKAKNITVDILKKYGLITS*" gene complement(228549..229352) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" promotor_-10 complement(229374..229392) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(229382) /Source="Nicolas_upshifts" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" promotor_-35 complement(229403..229411) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 229466..229472 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 229487..229505 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 229493 /Source="Nicolas_upshifts" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" CDS 229525..230778 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" /EC_number="1.11.2.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10529095, 12519760, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10529095, 12519760, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid beta-hydroxylating cytochrome P450" /protein_id="NP_388092.1" /db_xref="EnsemblGenomes-Gn:BSU02100" /db_xref="EnsemblGenomes-Tr:CAB12004" /db_xref="GOA:O31440" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002401" /db_xref="InterPro:IPR036396" /db_xref="PDB:1IZO" /db_xref="PDB:2ZQJ" /db_xref="PDB:2ZQX" /db_xref="SubtiList:BG12729" /db_xref="UniProtKB/Swiss-Prot:O31440" /translation="MNEQIPHDKSLDNSLTLLKEGYLFIKNRTERYNSDLFQARLLGK NFICMTGAEAAKVFYDTDRFQRQNALPKRVQKSLFGVNAIQGMDGSAHIHRKMLFLSL MTPPHQKRLAELMTEEWKAAVTRWEKADEVVLFEEAKEILCRVACYWAGVPLKETEVK ERADDFIDMVDAFGAVGPRHWKGRRARPRAEEWIEVMIEDARAGLLKTTSGTALHEMA FHTQEDGSQLDSRMAAIELINVLRPIVAISYFLVFSALALHEHPKYKEWLRSGNSRER EMFVQEVRRYYPFGPFLGALVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPDEF RPERFAEREENLFDMIPQGGGHAEKGHRCPGEGITIEVMKASLDFLVHQIEYDVPEQS LHYSLARMPSLPESGFVMSGIRRKS*" gene 229525..230778 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" misc_feature 229837..229844 /Source="Nicolas_upshift_promotors" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 229847 /Source="Nicolas_upshifts" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 230771 /Source="Nicolas_upshifts" /id="D78" /incds=0 /nref=5 /ntot=36 /MaxReadThrough="2.65245" /MaxDrop="6.12325" /score="-7.42298703" /energy="-14.7" /TU="NA" /idTUdmin="U143" /TUdmin=0 /isTUend="TRUE" CDS complement(230819..231079) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388093.1" /db_xref="EnsemblGenomes-Gn:BSU02110" /db_xref="EnsemblGenomes-Tr:CAB12005" /db_xref="SubtiList:BG12754" /db_xref="UniProtKB/Swiss-Prot:O31441" /translation="MKQKLLLSGLAVSTVGITSYLLKDPSNRQKAREFIHSMKMKITK QPDMETFPVDKAGHPDPQDIEDNKMVSEGSMYPVQYYDEKKK*" gene complement(230819..231079) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" downshifts complement(230838) /Source="Nicolas_upshifts" /id="D79" /incds=0 /nref=155 /ntot=247 /MaxReadThrough="3.63752" /MaxDrop="7.83539" /score="8.86703843" /energy="-12.4" /TU="U145" /idTUdmin="U145" /TUdmin="-387" /isTUend="FALSE" promotor_-10 complement(231109..231127) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(231118) /Source="Nicolas_upshifts" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" promotor_-35 complement(231141..231147) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 231271..231278 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 231288 /Source="Nicolas_upshifts" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" promotor_-10 231294..231313 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 231348..232967 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/amino acid transporter" /protein_id="NP_388094.2" /db_xref="EnsemblGenomes-Gn:BSU02120" /db_xref="EnsemblGenomes-Tr:CAB12006" /db_xref="GOA:Q45577" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12730" /db_xref="UniProtKB/Swiss-Prot:Q45577" /translation="MNQLHRRMGTFSLMMVGLGSMIGSGWLFGAWRAAQIAGPAAIIS WVIGMVVILFIALSYSELGSMFPEAGGMVKYTQYSHGSFIGFIAGWANWIAIVSVIPV EAVASVQYMSSWPWEWAKWTSGLVKNGTLTGEGLAFASVLLLIYFLLNYWTVNLFSKA NSLITIFKIIIPGLTIGALLFVGFHGENFTGGQSIAPNGWASVLTAVATSGIVFAFNG FQSPINMAGEAKNPGKSIPIAVVGSLFVATVIYVLLQIAFIGAVNPSDIAHGWSHLNF NSPFADLAIALNINWLVIVLYADAFVSPSGTGITYTATTSRMIYGMEKNKYMPSIFGK LHPIYGVPRQAMFFNLIVSFIFLFLFRGWGVLAEIISVATLISYITGPITVMTLRRTG KDLYRPLRLKGLNVIAPLGFIFASLVLYWARWPLTGQVLFIILIGLPIYFYYQAKAKW KGFGRNFKAGVWMVFYLLAMMVISYLGSDKFGGLNVIHYGWDMVLIAMVSLVFYVWAL KSGYQTEYLKDAKEINSQLLNGQSEAAAGKE*" gene 231348..232967 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" downshifts 232950 /Source="Nicolas_upshifts" /id="D80" /incds=0 /nref=183 /ntot=273 /MaxReadThrough="0.8051" /MaxDrop="6.79949" /score="24.7668372" /energy="-12.2" /TU="NA" /idTUdmin="U146" /TUdmin="-21" /isTUend="TRUE" CDS complement(233014..233895) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10913081, 21966272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 21966272; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted glycerophosphoryl diester phosphodiesterase" /protein_id="NP_388095.1" /db_xref="EnsemblGenomes-Gn:BSU02130" /db_xref="EnsemblGenomes-Tr:CAB12007" /db_xref="GOA:P37965" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="PDB:5T91" /db_xref="PDB:5T9B" /db_xref="PDB:5T9C" /db_xref="SubtiList:BG10646" /db_xref="UniProtKB/Swiss-Prot:P37965" /translation="MRKNRILALFVLSLGLLSFMVTPVSAASKGNLLSPDRILTVAHR GASGYVPEHTILSYETAQKMKADFIELDLQMTKDGKLIVMHDEKLDRTTNGMGWVKDH TLADIKKLDAGSWFNEAYPEKAKPQYVGLKVPTLEEVLDRFGKHANYYIETKSPDTYP GMEEKLIASLQKHKLLGKHSKPGQVIIQSFSKESLVKVHQLQPNLPTVQLLEAKQMAS MTDAALEEIKTYAVGAGPDYKALNQENVRMIRSHGLLLHPYTVNNEADMHRLLDWGVT GVFTNYPDLFHKVKKGY*" gene complement(233014..233895) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" downshifts complement(233025) /Source="Nicolas_upshifts" /id="D81" /incds=0 /nref=61 /ntot=107 /MaxReadThrough="2.31368" /MaxDrop="7.76277" /score="9.56390732" /energy="-11.4" /TU="NA" /idTUdmin="U147" /TUdmin=0 /isTUend="TRUE" upshifts complement(233938) /Source="Nicolas_upshifts" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" promotor_-10 complement(233947..233963) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(233972..233978) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(233994..235328) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8012593, 11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012593, 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate permease" /protein_id="NP_388096.1" /db_xref="EnsemblGenomes-Gn:BSU02140" /db_xref="EnsemblGenomes-Tr:CAB12008" /db_xref="GOA:P37948" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR005267" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR021159" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10645" /db_xref="UniProtKB/Swiss-Prot:P37948" /translation="MLNIFKPAPHIERLDDSKMDAAYKRLRLQVFIGIFIGYAGYYLL RKNFAFAIPYLQEQGFSKTELGLVLAAVSIAYGFSKFIMGMVSDRCNPRYFLATGLFL SAIVNILFVSMPWVTSSVTIMFIFMFINGWFQGMGWPPCGRTMAHWFSISERGTKMSI WNVAHNIGGGILAPLVTLGIAMFVTWKSVFFFPAIIAIIISFLIVLLVRDTPQSCGLP PIEEYRNDYPKHAFKNQEKELTTKEILFQYVLNNKFLWYIAFANVFVYFVRYGVVDWA PTYLTEAKGFSPEDSRWSYFLYEYAGIPGTILCGWISDRFFKSRRAPAGVLFMAGVFI AVLVYWLNPAGNPLVDNIALISIGFLIYGPVMLIGLQAIDLAPKKAAGTAAGLTGFFG YIGGSAFANAIMGFVVDRFNWNGGFIMLISSCILAIVFLALTWNTGKRAEHV*" gene complement(233994..235328) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" promotor_-35 234976..234985 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 234998..235624 /Source="Nicolas_S_feature" /locus_tag="new_234998_235624" /HighExp="S6, S8, S7, S5, BT, B36, G/S, C30, Pyr, B60" /AntisenseName="glpT" /AntisenseCor="-5.0958691169636701E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S81" promotor_-10 234998..235017 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 234998 /Source="Nicolas_upshifts" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" S_feature complement(235329..235401) /Source="Nicolas_S_feature" /locus_tag="new_235329_235401_c" /HighExp="G150, Oxctl, Paraq, S0, Diami, H2O2, Lbexp, dia5, dia0, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.042, 0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S82" promotor_no_box complement(235361..235461) /Source="Nicolas_upshift_promotors" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(235401) /Source="Nicolas_upshifts" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" S_feature complement(235403..235489) /Source="Nicolas_S_feature" /locus_tag="new_235403_235489_c" /HighExp="G150, Oxctl, S0, Diami, Lbexp, dia5, Paraq, dia0, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S83" promotor_-10 complement(235479..235498) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(235493) /Source="Nicolas_upshifts" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" promotor_-35 complement(235511..235518) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 235625..235873 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388097.1" /db_xref="EnsemblGenomes-Gn:BSU02150" /db_xref="EnsemblGenomes-Tr:CAB12009" /db_xref="GOA:O31442" /db_xref="InterPro:IPR020258" /db_xref="SubtiList:BG12731" /db_xref="UniProtKB/Swiss-Prot:O31442" /translation="MDELDIAFFILPLGIMLLSIVGTCICKNPYLMPMLSLVISLVLT FTIFNQSFLGWAVVYSLVSLALSYITLIVVRKRKESGN*" gene 235625..235873 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" promotor_-35 235897..235904 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 235904 /Source="Nicolas_upshifts" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" promotor_-10 235920..235939 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 235965..236882 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator with acetyltransferase domain" /protein_id="NP_388098.1" /db_xref="EnsemblGenomes-Gn:BSU02160" /db_xref="EnsemblGenomes-Tr:CAB12010" /db_xref="GOA:O31443" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12732" /db_xref="UniProtKB/Swiss-Prot:O31443" /translation="MKTRESSVGLKFRKFNRFYTNVLGFLNEHIYDSPFSLTETRILF EIYNTPNCTAKALQDKLGLDRGYVSRIVKQFEKEDLIYKQRSKDDARHHYIFVTETGK TIYKKLEEKANEQVELMLKVINQKEQHKLAEAMAEIEAILSQSLSARASEISIRDYFL SEDLQLLIEKQRQFYAEAHGWDDTFLAYLQETFDADIEKIWIAESGGKFAGSVGLVKH DEKTVQLRWFLVDADFRGRGLGTQLLEHLVAYCQDMKFDRIFLWTVSTMAEARPLYKK FGFRISEVKQEAPLWGQQLTEERWDLELS*" gene 235965..236882 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" CDS 236879..238129 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carboxylate transporter" /protein_id="NP_388099.1" /db_xref="EnsemblGenomes-Gn:BSU02170" /db_xref="EnsemblGenomes-Tr:CAB12011" /db_xref="GOA:O31444" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12733" /db_xref="UniProtKB/Swiss-Prot:O31444" /translation="MKRLHYAWIIVSVTFLILLAVQGVRLSFGAFVEPWERQFSIDRS TISLISTVSFIVYGISQPVIGRLVDKWGARAVLAWSALLTGVSIFLTYLVTSPWQLFL LYGLGVSLGVGGASNVAASVLVVNWFSKKRGLAFGIMEAGFGAGQMLLVPGSLMLIHW FSWKLTVVVLGLLLIVIVFPAALLMLRNNPSEKNTEPIGGLAASEKETAPKTTALSVA GMFRMRQFWFLIFPFLICGFTTVGLMDTHLIPFSHDHGFSTTVTSAAVSLLAGFNIAG ILLSGIVADRWSSRKILCILYAVRALSIVILIYSHEPYLLLAFAILFGLVDFATVAPT QMLATQYFQNYSIGLMIGWLSLAHQIGSALGAYVPGVIYTVTGEYTLAFYLSIGMLVL ASVMNVMLREPAAVTRDSAAVVDK*" gene 236879..238129 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" downshifts 238119 /Source="Nicolas_upshifts" /id="D82" /incds=0 /nref=57 /ntot=187 /MaxReadThrough="1.17226" /MaxDrop="5.55429" /score="12.1347284" /energy="-9.5" /TU="NA" /idTUdmin="U151" /TUdmin=0 /isTUend="TRUE" CDS complement(238164..238448) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminal end)" /db_xref="EnsemblGenomes-Gn:BSU02180" /db_xref="EnsemblGenomes-Tr:CAB12012" /db_xref="GOA:O31445" /db_xref="PSEUDO:CAB12012.2" /db_xref="SubtiList:BG12734" /db_xref="UniProtKB/Swiss-Prot:O31445" /translation="MNHCLHSNTLAKIVCTVTLITLYFYFFSTRFNELIELAVQMFFA LIGLFWVFIVSPFSRKVQISERFKQKSENARIVGMIDFVLEQKYKKSISE*" gene complement(238164..238448) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /pseudo downshifts complement(238217) /Source="Nicolas_upshifts" /id="D83" /incds=0 /nref=4 /ntot=189 /MaxReadThrough="2.49989" /MaxDrop="3.7302" /score="13.7144473" /energy="-12.6" /TU="U153" /idTUdmin="U153" /TUdmin="-22" /isTUend="TRUE" CDS complement(238354..238476) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function YbfE (N-terminal fragment)" /db_xref="PSEUDO:SOX90538.1" /translation="MLNQLKVFFSEPLLTFKHTCQNRMYCDINNVILLFFQHSF*" gene complement(238354..238476) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /pseudo S_feature complement(238449..238569) /Source="Nicolas_S_feature" /locus_tag="new_238449_238569_c" /HighExp="Lbexp, dia0, LBGexp, G150, Mt0, H2O2, dia5, M0t45, G135, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, Sig-" /TUshortPSig="0.899, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S84" promotor_-10 complement(238554..238572) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(238569) /Source="Nicolas_upshifts" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" S_feature complement(238571..238643) /Source="Nicolas_S_feature" /locus_tag="new_238571_238643_c" /HighExp="Lbexp, dia0, LBGexp, HPh, G150, H2O2, dia5, Mt0, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S85" promotor_-35 complement(238589..238594) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(238644..239555) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388101.1" /db_xref="EnsemblGenomes-Gn:BSU02190" /db_xref="EnsemblGenomes-Tr:CAB12013" /db_xref="GOA:O31446" /db_xref="SubtiList:BG12735" /db_xref="UniProtKB/Swiss-Prot:O31446" /translation="MKNDQIVFEKTKNIAHDINQMQNQQEIIDYLFRQDSLTLNQLKH YYSEPSLPLQFLVKVAVLCMFISMTLASFLFIQAKEVFTNTILSDISPAVFSIFTVIC IFMTYTKIIKKGNKNKGKASLNQRSEFYEKNKLINTILYKKYKMDQQNIQANKHTASD NEDSMNFSAVLNHVLTISKNDKELLGYLDTRDNAMLSQLKAYFSTRPFSLPHYMSLMF CGSIIVVYATSLFSGQINYIDIPHIFIFLLLIIFLKILIDLIKLLNISRKGQLHTVLH FAQRAEYLRMRGVIDFILTERYNKKIM*" gene complement(238644..239555) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" S_feature complement(239556..239643) /Source="Nicolas_S_feature" /locus_tag="new_239556_239643_c" /HighExp="LBGexp, Lbexp, G150, dia5, dia0, G135, Oxctl, H2O2, Mt0, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S86" CDS complement(239644..241842) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pepdidoglycan binding protein" /protein_id="NP_388102.1" /db_xref="EnsemblGenomes-Gn:BSU02200" /db_xref="EnsemblGenomes-Tr:CAB12014" /db_xref="GOA:O31447" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG12736" /db_xref="UniProtKB/Swiss-Prot:O31447" /translation="MVDEMVLITQQWLNDTYSGKHGYNPVEESGKTGWDTIYGLTRAL QIELGISEPADNFGPTTQRLFKPLKRQAPDSKPSNMNFILQGALWCKGFNPGGFTGVF YEKTENAVKEFQKAAGLTTQDGIVTTLIMKALLDMSAFKLVSGGDSRIRQIQQNLNRD YNDYIGLMPCDGLYGRDTNKALIYALQKEEGMSTSVANGFFGNGTTSLCPTLTPGDSR TGFVLIVQYALYCNGKSFDPGEFDGKYGVGVVSAVKAFQEFMCLPQTGYADMPTIKAL LSSSGDTTRTASACDTATIITAEKAQTLRNNGYKTVGRYLTGNVRTSSGLTSKALTSK ELAVILDAGLKVFPIYQDGGYESSYFVKDQGTRDAYSAASAARRLGFPSGTTIYFAVD FDAYDYEVTDKIIPYFQEIKSAFTKMQTFSTAPKYEIGVYGPRNICIRTSEAGLTKYS FVANMSTGFSGNLGYPMPNNWAFDQFYEGTIGSGSGSIGIDKDGYSGRDSGASNVNPP SDPVYDARLRTLTDILSTIPALENLTSLANAMFEFDTTETIFTSPELDIILSTSLLAT IPSEGSPNTITITNGKPGAYITGLLGDTQTSLTASQIDSYQNLLNSLSLSVRNGYLEV YVNPTAESLNIQIKIYTPDIPVGDNVTTGLTTTITFKIKTYKGVPVTSPESELALDWP SYDQYLFPVVGVAALLLIGNMGSDLTNNKGVKVATALSAMLLAIFAYYTS*" gene complement(239644..241842) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" misc_feature complement(241877..241895) /Source="Nicolas_upshift_promotors" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(241889) /Source="Nicolas_upshifts" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" CDS complement(241917..242837) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388103.1" /db_xref="EnsemblGenomes-Gn:BSU02210" /db_xref="EnsemblGenomes-Tr:CAB12015" /db_xref="GOA:O31448" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12737" /db_xref="UniProtKB/Swiss-Prot:O31448" /translation="MNIQRETSGHIAAIVTILIWGTTFISTKVLLADFSPMEILFYRF LMGFIALILVRPNMIPFRNWRQELLFAGAGLFGVTLYFLLENIALTYTYASNVGMIVS IIPMITAVLAHFLLEGEKLRLTFLIGFISALIGLLLITFNGNVVLRLNPLGDIMAAGA ALVFGGYSIFMKKLSAYEYHIIELTQRVFLYGLLFMVPALFLFDFHFDLSRFSSASNI LNMLFLGIGASALCFATWNYSVGVLGAVKSSAYIYMVPVITIAASVLILHENMTWIAL LGGALTLLGLYISELKPKAKLLENGCKMDA*" gene complement(241917..242837) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" CDS complement(242834..243661) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family, cupin family)" /protein_id="NP_388104.1" /db_xref="EnsemblGenomes-Gn:BSU02220" /db_xref="EnsemblGenomes-Tr:CAB12016" /db_xref="GOA:O31449" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12738" /db_xref="UniProtKB/Swiss-Prot:O31449" /translation="MQNETRTLQLDPHLHIEAYRFKGIMQKFPNHFHDYYVIGFIEKG QRYLACQDQEYIINPGDLLLFNPRDTHSCEQIDGRTLDYRCINVMPDIMEKAVKEITG SGHLPYFSQHVLFRHELTASLQELHILISEEKQALRKEELFLHLLEELIRHYSDVTFL SSVPEPSDEVKMVCEFLEEHYAENVTLNDLSELTGWSKYHLLRSFTKQKGITPNSYME TIRINQAKKLLEQGVRPIDAAFQTGFSDQSHMTKFFKRQVGLTPKQYMKIFEKELHR* " gene complement(242834..243661) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" misc_feature complement(243688..243707) /Source="Nicolas_upshift_promotors" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(243695) /Source="Nicolas_upshifts" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" promotor_-35 243835..243838 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 243853..243872 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 243858 /Source="Nicolas_upshifts" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" CDS 243892..245046 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" /EC_number="2.1.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496533; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase 2" /protein_id="NP_388105.1" /db_xref="EnsemblGenomes-Gn:BSU02230" /db_xref="EnsemblGenomes-Tr:CAB12017" /db_xref="GOA:P39771" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005862" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10924" /db_xref="UniProtKB/Swiss-Prot:P39771" /translation="MYQSKKVLLLGSGELGKEVVIEAQRLGVQTVAVDSYEHAPAMQV AHNSYVVDMLDPEQIRTIIEKENPDLIVPEVEAIATDELLKLEEEGFHVIPNARAAKL TMDREGIRRLAAETLGLATAGYEFANTYDEFIQAAAQIGFPCVVKPLMSSSGKGQSVC RSEADLESCWETAMEGGRVKNGRVIVEEFIPFESEITLLTVRAVNGTAFCEPIGHVQK DGDYIESWQPHDMTEQQIEEAKHIAKTITDELGGYGLFGVELFLAKDRVYFSEVSPRP HDTGLVTLVTQNLSEFALHVRAILGFPITEITQLSPGASRPLKAPEELADYTVEGLEN ALAVPKTQVRVFGKPITKAGRRMAVALSAADSVETARENAKKALDQLILK*" gene 243892..245046 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" downshifts 245027 /Source="Nicolas_upshifts" /id="D84" /incds=0 /nref=100 /ntot=189 /MaxReadThrough="2.6996" /MaxDrop="5.22319" /score="39.2561117" /energy="-15.1" /TU="NA" /idTUdmin="U155" /TUdmin=0 /isTUend="TRUE" promotor_-35 245107..245112 /Source="Nicolas_upshift_promotors" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="promotor_-35" upshifts 245121 /Source="Nicolas_upshifts" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" promotor_-10 245127..245145 /Source="Nicolas_upshift_promotors" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="promotor_-10" promotor_-35 245161..245168 /Source="Nicolas_upshift_promotors" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 245183..245202 /Source="Nicolas_upshift_promotors" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 245183 /Source="Nicolas_upshifts" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" CDS 245190..246131 /gene="mpr" /locus_tag="BSU_02240" /old_locus_tag="BSU02240" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15205417, 15375126, 21819557, 25666135; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular glutamyl-endopeptidase" /protein_id="NP_388106.1" /db_xref="EnsemblGenomes-Gn:BSU02240" /db_xref="EnsemblGenomes-Tr:CAB12018" /db_xref="GOA:P39790" /db_xref="InterPro:IPR000126" /db_xref="InterPro:IPR001254" /db_xref="InterPro:IPR008256" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR018114" /db_xref="InterPro:IPR028301" /db_xref="SubtiList:BG10690" /db_xref="UniProtKB/Swiss-Prot:P39790" /translation="MKLVPRFRKQWFAYLTVLCLALAAAVSFGVPAKAAENPQTSVSN TGKEADATKNQTSKADQVSAPYEGTGKTSKSLYGGQTELEKNIQTLQPSSIIGTDERT RISSTTSFPYRATVQLSIKYPNTSSTYGCTGFLVNPNTVVTAGHCVYSQDHGWASTIT AAPGRNGSSYPYGTYSGTMFYSVKGWTESKDTNYDYGAIKLNGSPGNTVGWYGYRTTN SSSPVGLSSSVTGFPCDKTFGTMWSDTKPIRSAETYKLTYTTDTYGCQSGSPVYRNYS DTGQTAIAIHTNGGSSYNLGTRVTNDVFNNIQYWANQ*" gene 245190..246131 /gene="mpr" /locus_tag="BSU_02240" /old_locus_tag="BSU02240" CDS 246094..246492 /gene="ybfJ" /locus_tag="BSU_02250" /old_locus_tag="BSU02250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388107.1" /db_xref="EnsemblGenomes-Gn:BSU02250" /db_xref="EnsemblGenomes-Tr:CAB12019" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR019730" /db_xref="SubtiList:BG12739" /db_xref="UniProtKB/Swiss-Prot:O31451" /translation="MYSTIFNIGQINKYSKLAIFMSILFLCGCSSQTHSSQKETTIPV TLHVEDAKGLPVEGVQVTIVKAPSSDEEPSTEIGEILGKTDKNGDIKWDTGRKGDYSV ALTKGETSVTHHISLTEDKKDHAIPLVFKE*" gene 246094..246492 /gene="ybfJ" /locus_tag="BSU_02250" /old_locus_tag="BSU02250" promotor_-10 complement(246186..246200) /Source="Nicolas_upshift_promotors" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(246196) /Source="Nicolas_upshifts" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(246216..246221) /Source="Nicolas_upshift_promotors" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 246479 /Source="Nicolas_upshifts" /id="D85" /incds=0 /nref=19 /ntot=51 /MaxReadThrough="3.50775" /MaxDrop="5.06025" /score="29.4582027" /energy="-15.4" /TU="U156" /idTUdmin="U157" /TUdmin=0 /isTUend="TRUE" promotor_-35 246548..246555 /Source="Nicolas_upshift_promotors" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 246570..246589 /Source="Nicolas_upshift_promotors" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 246583..246657 /Source="Nicolas_S_feature" /locus_tag="new_246583_246657" /HighExp="Cold, LoTm, S0, aero, ferm, T-4.40H, nit, T-5.40H, T-0.40H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.973" /label="S87" upshifts 246583 /Source="Nicolas_upshifts" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" CDS 246658..247548 /gene="cesB" /locus_tag="BSU_02260" /old_locus_tag="BSU02260" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11389736, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11389736, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enantioselective carboxylesterase" /protein_id="NP_388108.1" /db_xref="EnsemblGenomes-Gn:BSU02260" /db_xref="EnsemblGenomes-Tr:CAB12020" /db_xref="GOA:O31452" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:4CCY" /db_xref="SubtiList:BG12740" /db_xref="UniProtKB/Swiss-Prot:O31452" /translation="MIQDSMQFAAVESGLRFYQAYDQSLSLWPIESEAFYVSTRFGKT HIIASGPKDAPSLILLHGGLFSSAMWYPNIAAWSSQFRTYAVDIIGDKNKSIPSAAME TRADFAEWMKDVFDSLGLETAHLAGLSLGGSHIVNFLLRAPERVERAVVISPAEAFIS FHPDVYKYAAELTGARGAESYIKWITGDSYDLHPLLQRQIVAGVEWQDEQRSLKPTEN GFPYVFTDQELKSIQVPVLLMFGEHEAMYHQQMAFERASVLVPGIQAEIVKNAGHLLS LEQPEYVNQRVLSFLCGGIK*" gene 246658..247548 /gene="cesB" /locus_tag="BSU_02260" /old_locus_tag="BSU02260" promotor_-35 246892..246899 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 246908 /Source="Nicolas_upshifts" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" promotor_-10 246913..246931 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 247549..247743 /Source="Nicolas_S_feature" /locus_tag="new_247549_247743" /HighExp="Cold, LBGstat, Paraq, Oxctl, H2O2, dia15, G135, Diami, Lbexp, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.867, 1" /TUlongSig="SigEF" /TUlongPSig="0.973" /label="S88" CDS 247744..248277 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" /EC_number="2.7.8.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 15743965, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 15743965, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine synthase" /protein_id="NP_388109.1" /db_xref="EnsemblGenomes-Gn:BSU02270" /db_xref="EnsemblGenomes-Tr:CAB12021" /db_xref="GOA:P39823" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004533" /db_xref="SubtiList:BG11012" /db_xref="UniProtKB/Swiss-Prot:P39823" /translation="MNYIPCMITIGNFICGLLAIHSLLYHNIHSAVLFIFTGMFLDFF DGMAARKLNAVSDMGRELDSFADLVTFGVAPSMLAYSVALYTLPFIGILCALTYSICG MLRLSKFNIEQSKLPTFIGMPIPFAGMCLVILSFTYNPILLAIGTCGLSYLMVSKIKF PHFKKHAAENLESGRWN*" gene 247744..248277 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" CDS 248268..248756 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 14762009, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane phosphatase" /protein_id="NP_388110.1" /db_xref="EnsemblGenomes-Gn:BSU02280" /db_xref="EnsemblGenomes-Tr:CAB12022" /db_xref="GOA:O31453" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG12741" /db_xref="UniProtKB/Swiss-Prot:O31453" /translation="MELVQQLIADYGYLAIFLMLVLGIVGLPIPDEVMMTVVGYFTHT DVLNYELSILISFVGALLGMLISYMIGRKAGRPFIDKYGKWVGLKEKRMMKVEKWMKK YGPYSLILGYFIPGVRHVTCYFSGIGKMDLKTYVAFAAIGAFLWCFVFITIGRVIGII HV*" gene 248268..248756 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" CDS 248749..249540 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" /EC_number="4.1.1.65" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 9422599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 9422599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine decarboxylase; 32 kDa precursor processed into a 29 kDa protein" /protein_id="NP_388111.1" /db_xref="EnsemblGenomes-Gn:BSU02290" /db_xref="EnsemblGenomes-Tr:CAB12023" /db_xref="GOA:P39822" /db_xref="InterPro:IPR003817" /db_xref="InterPro:IPR033177" /db_xref="InterPro:IPR033178" /db_xref="SubtiList:BG11013" /db_xref="UniProtKB/Swiss-Prot:P39822" /translation="MFNTAVKILYRSLIELTNHRLSSYLIKGFCESKISKPVIPLFSK HFRLNWDDVDGTAADYGSLSELFIRQINLERRPVSKEAHAVVSPVDGVVQTVGIINPN QTFTVKGKDYSFAELTGCKSADHQYNGGYFVVLYLSPRHYHRFHSPISCRYQKLAELG NRSYPVNQLGLKYGKDVLSKNYRFVYELNSGSRNVLMIPVGAMNINSIVQTNTRTELE IGEELGYFSFGSTVILVFEKDAFQPSAHLAEGQEVQVGELIGYEE*" gene 248749..249540 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" downshifts 249515 /Source="Nicolas_upshifts" /id="D86" /incds=0 /nref=101 /ntot=236 /MaxReadThrough="3.18138" /MaxDrop="4.25536" /score="-2.98360164" /energy="-8" /TU="U159" /idTUdmin="U160" /TUdmin=0 /isTUend="TRUE" CDS 249595..249873 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388112.1" /db_xref="EnsemblGenomes-Gn:BSU02300" /db_xref="EnsemblGenomes-Tr:CAB12024" /db_xref="SubtiList:BG12742" /db_xref="UniProtKB/Swiss-Prot:O31454" /translation="MEKQIISWITDYQNTGDEAVLRQVREVCWPIVEAVLQEKVMDDE QANNLREKGIERFPFIISKYQADVQLPVETFLQNTYRFYFHQVMRESS*" gene 249595..249873 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" promotor_-35 249916..249925 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 249934 /Source="Nicolas_upshifts" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" promotor_-10 249938..249953 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 249979..251319 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_388113.1" /db_xref="EnsemblGenomes-Gn:BSU02310" /db_xref="EnsemblGenomes-Tr:CAB12025" /db_xref="GOA:O31455" /db_xref="InterPro:IPR007815" /db_xref="SubtiList:BG12743" /db_xref="UniProtKB/Swiss-Prot:O31455" /translation="MKRMIVRMTLPLLIVCLAFSSFSASARAASEEKYWDHWIERHAQ PLDASNASNKDLRFLKKVLKGKRIVQLGETTHGAGEINATKVRMIKYLHEELGYDVLA FESGFPDTNASYLNMDQLTPKSTMKNSIYAVWHTEDVVELFDYMKEQKEKGDPLILTG FDIQSMKNSFNVAATQWVKAVDPEKAELLSQSENDFSTLVTDSNTFDEFSQKKEKLVK NYQKLIKFTKTHASELKENLPKEPKAYEMFMHSLQLRIDVMETYMLEEMKEKLEEYPE NIEDFSFFMRDRMMAEQFQWVADTLYPKKKIIVWGHNYHLRKQNTKMIKDWVQLNGPN MGDYLPERLKKQTYTIGIYAYSGASLDSSDNKTVKPVTSPPPSGSLEALLKAADRPAV FVDFLHTKNKKGTSWMYTPRTALYWGYMEEQMILKEQYDGVIWLEHITPSVIIK*" gene 249979..251319 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" downshifts 251319 /Source="Nicolas_upshifts" /id="D87" /incds=0 /nref=12 /ntot=60 /MaxReadThrough="3.64301" /MaxDrop="6.34998" /score="14.4442651" /energy="-13.3" /TU="U161" /idTUdmin="U162" /TUdmin="-1122" /isTUend="FALSE" upshifts 251385 /Source="Nicolas_upshifts" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" misc_feature 251388..251407 /Source="Nicolas_upshift_promotors" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 251427..252314 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388114.1" /db_xref="EnsemblGenomes-Gn:BSU02320" /db_xref="EnsemblGenomes-Tr:CAB12026" /db_xref="GOA:O31456" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12744" /db_xref="UniProtKB/Swiss-Prot:O31456" /translation="MYYEKAVQKTINWIESHLHEQISNEDIVNVSSFSKFHFHRIFQK EVGMSVASYIRLRRLANAAAALLYTDHRIIDIALYYQFESQEAFTRTFKKMYHMPPGA YRTFMKRFTSKKEESYMEKKMKGWVLSGSHPFQFEMGIDRENVHQGKASGYLKSTMVQ DIGEFATMMQQFKADRYLGKRLRLSSFIKTKGVQHFASLWMRVDSAADDVLQFDNMSN RPITGTTNWNHYAIVLDVPENSAVISFGVQLSGPGQVWMDHVVFEEVDESVPSTNLEM PGELLDEPVNLSFEEELQK*" gene 251427..252314 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" S_feature 252315..252458 /Source="Nicolas_S_feature" /locus_tag="new_252315_252458" /HighExp="T0.30H, T-1.40H, T0.0H, T-1.10H, Salt, aero, ferm, T-0.40H, T-2.40H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.838, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S89" promotor_-35 252430..252437 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 252451..252470 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 252460 /Source="Nicolas_upshifts" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" CDS 252514..253482 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with rhodanese domain" /protein_id="NP_388115.1" /db_xref="EnsemblGenomes-Gn:BSU02330" /db_xref="EnsemblGenomes-Tr:CAB12027" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR020936" /db_xref="InterPro:IPR022111" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG12745" /db_xref="UniProtKB/Swiss-Prot:O31457" /translation="MEKQYRVLLYYKYVPIEDPEAFREQHLAFCKELGLLGRILVSSE GINGTVSGTVEQTEKYMETMKADPRFADMVFKIDEAEGHAFKKIFVRHKKELVTLRLE DDVDPNETTGQHLKPAEFYEKMQDPNTIVIDARNDYEYDLGHFRGAVRPDIEAFRELP EWIEEHKDMLEGKKILTYCTGGVRCEKFSGWLVKQGFEDVAQLDGGIVTYGKDPEVQG KLWDGQCYVFDERISVPVNRVEHVIVGKDYFTGEPCERYVNCANPSCNKKMICTPENE YKYMRSCSHECRTNPRNLYVKEHNMTEEEVNARLAAIETEDHAAAE*" gene 252514..253482 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" promotor_-10 complement(253336..253354) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(253353) /Source="Nicolas_upshifts" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(253370..253375) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 253479 /Source="Nicolas_upshifts" /id="D88" /incds=0 /nref=238 /ntot=271 /MaxReadThrough="2.06825" /MaxDrop="7.49655" /score="4.11635522" /energy="-7.8" /TU="U163" /idTUdmin="U161" /TUdmin=4 /isTUend="TRUE" downshifts complement(253518) /Source="Nicolas_upshifts" /id="D89" /incds=0 /nref=59 /ntot=147 /MaxReadThrough="0.54212" /MaxDrop="6.33244" /score="2.56774646" /energy="-7.5" /TU="NA" /idTUdmin="U165" /TUdmin=11 /isTUend="TRUE" CDS complement(253518..254762) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7751298, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7751298, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/glutamate symport protein" /protein_id="NP_388116.1" /db_xref="EnsemblGenomes-Gn:BSU02340" /db_xref="EnsemblGenomes-Tr:CAB12028" /db_xref="GOA:P39817" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11015" /db_xref="UniProtKB/Swiss-Prot:P39817" /translation="MKKLIAFQILIALAVGAVIGHFFPDFGMALRPVGDGFIRLIKMI VVPIVFSTIVIGAAGSGSMKKMGSLGIKTIIWFEVITTLVLGLGLLLANVLKPGVGLD LSHLAKKDIHELSGYTDKVVDFKQMILDIIPTNIIDVMARNDLLAVIFFAILFGVAAA GIGKASEPVMKFFESTAQIMFKLTQIVMVTAPIGVLALMAASVGQYGIELLLPMFKLV GTVFLGLFLILFVLFPLVGLIFQIKYFEVLKMIWDLFLIAFSTTSTETILPQLMDRME KYGCPKRVVSFVVPSGLSLNCDGSSLYLSVSCIFLAQAFQVDMTLSQQLLMMLVLVMT SKGIAAVPSGSLVVLLATANAVGLPAEGVAIIAGVDRVMDMARTGVNVPGHAIACIVV SKWEKAFRQKEWVSANSQTESI*" gene complement(253518..254762) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" promotor_-10 complement(254796..254814) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(254805) /Source="Nicolas_upshifts" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" promotor_-35 complement(254825..254833) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(254833..254851) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(254849) /Source="Nicolas_upshifts" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" promotor_-35 complement(254867..254872) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(254907..256802) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" /EC_number="2.7.1.193" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10627040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucosamine-specific enzyme IICBA component" /protein_id="NP_388117.1" /db_xref="EnsemblGenomes-Gn:BSU02350" /db_xref="EnsemblGenomes-Tr:CAB12029" /db_xref="GOA:P39816" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11014" /db_xref="UniProtKB/Swiss-Prot:P39816" /translation="MFKKAFQILQQLGRALMTPVAVLPAAGLLLRFGDKDLLNIPIIK DAGGVVFDNLPLIFAVGVAIGLAGGEGVAGLAAVIGYLILTVTLDNMGKLLGLQPPYE GAEHLIDMGVFGGIIIGLLAAYLYKRFSSIELHPVLGFFSGKRFVPIITSVSSLVIGV IFSFVWPLIQNGINAASSLIADSTVGLFFYATIYRLLIPFGLHHIFYTPFYFMMGEYT DPSTGNTVTGDLTRFFAGDPTAGRFMMGDFPYMIFCLPAVALAIIHTARPEKKKMISG VMISAALTSMLTGITEPVEFSFLFVAPVLYLINSILAGVIFVVCDLFHVRHGYTFSGG GIDYVLNYGLSTNGWVVIPVGIVFAFIYYYLFRFAILKWNLKTPGRETDEDGQNEEKA PVAKDQLAFHVLQALGGQQNIANLDACITRLRVTVHQPSQVCKDELKRLGAVGVLEVN NNFQAIFGTKSDALKDDIKTIMAGGVPATAAALDTVTDKPLKPDSDETFIYPIKGETV SLGDVPDQVFSEKMMGEGFAIIPSEGKVVAPADGEIVSIFPTKHAIGFMSAGGTEILI HVGIDTVKLNGEGFEAHVTSGQAVKQGELLLTFDLNYIKQHAASAITPVIFTNTSEED LKHIQMK*" gene complement(254907..256802) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" downshifts complement(254923) /Source="Nicolas_upshifts" /id="D90" /incds=0 /nref=56 /ntot=192 /MaxReadThrough="1.9947" /MaxDrop="6.51864" /score="5.87664177" /energy="-12.1" /TU="NA" /idTUdmin="U168" /TUdmin="-8" /isTUend="TRUE" misc_feature 256668..256687 /Source="Nicolas_upshift_promotors" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 256685 /Source="Nicolas_upshifts" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(256823..257572) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" /EC_number="3.5.99.6" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:23667565, 27002132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 27002132; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate deaminase" /protein_id="NP_388118.1" /db_xref="EnsemblGenomes-Gn:BSU02360" /db_xref="EnsemblGenomes-Tr:CAB12030" /db_xref="GOA:O31458" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="SubtiList:BG12746" /db_xref="UniProtKB/Swiss-Prot:O31458" /translation="MKILIAEHYEELCKLSAAIIKEQIQAKKDAVLGLATGSTPVGLY KQLISDYQAGEIDFSKVTTFNLDEYAGLSPSHPQSYNHFMHEHLFQHINMQPDHIHIP QGDNPQLEAACKVYEDLIRQAGGIDVQILGIGANGHIGFNEPGSDFEDRTRVVKLSES TIQANARFFGGDPVLVPRLAISMGIKTIMEFSKHIVLLASGEEKADAIQKMAEGPVTT DVPASILQKHNHVTVIADYKAAQKLKSASFS*" gene complement(256823..257572) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" S_feature 257545..257726 /Source="Nicolas_S_feature" /locus_tag="new_257545_257726" /HighExp="H2O2, T1.30H, G135, dia15, G150, G180, LBGstat, T2.0H, T0.30H, M9-stat" /AntisenseName="nagBB" /AntisenseCor="0.458837556034909" /AntisenseRegPval="-14.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S90" S_feature complement(257573..257643) /Source="Nicolas_S_feature" /locus_tag="new_257573_257643_c" /HighExp="S1, Diami, MG 5, MG t5, dia5, MG 15, MG 10, LPhT, Paraq, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S91" promotor_-10 complement(257632..257651) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(257647) /Source="Nicolas_upshifts" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" promotor_-35 complement(257667..257674) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 257713..257720 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 257728 /Source="Nicolas_upshifts" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" promotor_-10 257733..257752 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 257791..258498 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23667565, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator-GlcN6P (GntR family)" /protein_id="NP_388119.1" /db_xref="EnsemblGenomes-Gn:BSU02370" /db_xref="EnsemblGenomes-Tr:CAB12031" /db_xref="GOA:O31459" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12747" /db_xref="UniProtKB/Swiss-Prot:O31459" /translation="MTALYSVIKFKIIELIKSGKYQANDQLPTESEFCEQYDVSRTTV RLALQQLELEGYIKRIQGKGTFVSAAKIQTPIPHKITSFAEQMRGLRSESKVLELVVI PADHSIAELLKMKENEPVNKLVRVRYAEGEPLQYHTSYIPWKAAPGLAQEECTGSLFE LLRTKYNIEISRGTESIEPILTDETISGHLLTNVGAPAFLSESLTYDKNEEVVEYAQI ITRGDRTKFTVEQSYHS*" gene 257791..258498 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" promotor_-35 258464..258465 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 258481..258495 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 258491 /Source="Nicolas_upshifts" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" CDS 258532..258807 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12897008, 23667565" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (B. subtilis-specific)" /protein_id="NP_388120.1" /db_xref="EnsemblGenomes-Gn:BSU02380" /db_xref="EnsemblGenomes-Tr:CAB12032" /db_xref="GOA:O31460" /db_xref="InterPro:IPR012867" /db_xref="SubtiList:BG12748" /db_xref="UniProtKB/Swiss-Prot:O31460" /translation="MFLFTNGKVLWGAVIAAFILSIVFYPFLPTQMPIHYDVANSPDL TVNKLAGTVMLPVLMVVFAWARKINWQFVFAVYILLICHIVVLCLAL*" gene 258532..258807 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" promotor_-10 complement(258590..258608) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(258596) /Source="Nicolas_upshifts" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(258623..258629) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 258799 /Source="Nicolas_upshifts" /id="D91" /incds=0 /nref=20 /ntot=130 /MaxReadThrough="2.42422" /MaxDrop="3.75723" /score="4.58454735" /energy="-9.4" /TU="NA" /idTUdmin="U169" /TUdmin=0 /isTUend="TRUE" promotor_-35 258850..258854 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 258870..258889 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 258876 /Source="Nicolas_upshifts" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" S_feature 258887..259015 /Source="Nicolas_S_feature" /locus_tag="new_258887_259015" /HighExp="T2.30H, S5, T2.0H, T1.30H, M9-stat, T3.0H, T3.30H, S4, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S92" CDS 259016..260086 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15060025, 15102328, 20332210, 23429746" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15060025, 15102328, 20332210, 23429746; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucine-valine aminotransferase / aromatic amino acid aminotransferase" /protein_id="NP_388121.1" /db_xref="EnsemblGenomes-Gn:BSU02390" /db_xref="EnsemblGenomes-Tr:CAB12033" /db_xref="GOA:O31461" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG12749" /db_xref="UniProtKB/Swiss-Prot:O31461" /translation="MNKLIEREKTVYYKEKPDPSSLGFGQYFTDYMFVMDYEEGIGWH HPRIAPYAPLTLDPSSSVFHYGQAVFEGLKAYRTDDGRVLLFRPDQNIKRLNRSCERM SMPPLDEELVLEALTQLVELEKDWVPKEKGTSLYIRPFVIATEPSLGVKASRSYTFMI VLSPVGSYYGDDQLKPVRIYVEDEYVRAVNGGVGFAKTAGNYAASLQAQRKANELGYD QVLWLDAIEKKYVEEVGSMNIFFVINGEAVTPALSGSILSGVTRASAIELIRSWGIPV REERISIDEVYAASARGELTEVFGTGTAAVVTPVGELNIHGKTVIVGDGQIGDLSKKL YETITDIQLGKVKGPFNWTVEV*" gene 259016..260086 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" downshifts 260075 /Source="Nicolas_upshifts" /id="D92" /incds=0 /nref=124 /ntot=245 /MaxReadThrough="1.34575" /MaxDrop="6.88046" /score="13.1364544" /energy="-9.4" /TU="NA" /idTUdmin="U172" /TUdmin=0 /isTUend="TRUE" CDS complement(260123..261535) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid permease" /protein_id="NP_388122.1" /db_xref="EnsemblGenomes-Gn:BSU02400" /db_xref="EnsemblGenomes-Tr:CAB12034" /db_xref="GOA:O31462" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12750" /db_xref="UniProtKB/Swiss-Prot:O31462" /translation="MNSAHNKNETTFQRSMKSRHLFMLSLGGVIGTGLFLSSGYTIQQ AGPAGTILAYLVGAGIVYLVMLCLGELSVAMPVTGAFHTYAAKYIGPGTGFTVAWLYW LTWTVALGSEFTAAGLLMQRWFPHTSVWMWSAVFALFIFLLNAFSVKFFAESEFWFSS IKVLAIVLFILLGGSAMFGIIPIKGGEAAPMLSNFTAEGGLFPNGFVPILMTMLSVNF AFSGTELIGIAAGESVDPDKTIPKAIKTTVWRLSLFFVGTIFVLSGLIPIQDAGVIKS PFVAVFDRVGVPYAADIMNFVILTAILSAANSGLYASSRMLWSLSKEKTLHPTFAKLT SKGTPFNALVFSMIGGILSLLSSVFAPDTVYVVLVSISGFAVVVVWMGIAASQFMFRK RYIEAGNKVTDLKYRTPLYPFVPIAAFLLCLASVVGIAFDPNQRIALYCGVPFMAICY AIYYVKNRKSQPAADMTHSK*" gene complement(260123..261535) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" downshifts complement(260140) /Source="Nicolas_upshifts" /id="D93" /incds=0 /nref=43 /ntot=166 /MaxReadThrough="0.37503" /MaxDrop="5.92001" /score="6.94246417" /energy="-9.4" /TU="NA" /idTUdmin="U173" /TUdmin="-11" /isTUend="TRUE" S_feature complement(261536..261647) /Source="Nicolas_S_feature" /locus_tag="new_261536_261647_c" /HighExp="BMM, S1, MG 45, MG 60, UNK1, MG t5, MG 10, MG 90, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S93" promotor_-10 complement(261620..261639) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(261647) /Source="Nicolas_upshifts" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" promotor_-35 complement(261654..261661) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(261656..262603) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11267663, 15995196, 17264075; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homocysteine methylase using (R,S)AdoMet" /protein_id="NP_388123.1" /db_xref="EnsemblGenomes-Gn:BSU02410" /db_xref="EnsemblGenomes-Tr:CAB12035" /db_xref="GOA:O31463" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR017226" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG12751" /db_xref="UniProtKB/Swiss-Prot:O31463" /translation="MNPIQHILDTYPLIVLDGAMATELERKGCNLNDSLWSAKILMEE PELIKQVHTDYFAAGADCAITASYQSTFEGFAARGLSEAEARRLIELSVSIAAEARDE FWSLEENRLNRPKPIIAASIGPYGAYLADGSEYRGNYAISEDELIEFHRPRMKALIEA GADVLACETIPCLTEAKAIVRLLKEFPETYAWISFSAKDGLHISDGTPAADCASWLDE HRQIAALGINCTPLQHIPSLIEELKKNTSKPIIVYPNSGEQYDPETKTWNGAACAESY GASARTWHEKGARLIGGCCRTKPENIQEIAAWARSLKTT*" gene complement(261656..262603) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" promotor_-10 complement(262641..262660) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-10" upshifts complement(262658) /Source="Nicolas_upshifts" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" promotor_-35 complement(262675..262682) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-35" CDS complement(262732..264168) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 15995196, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine transporter" /protein_id="NP_388124.2" /db_xref="EnsemblGenomes-Gn:BSU02420" /db_xref="EnsemblGenomes-Tr:CAB12036" /db_xref="GOA:O31464" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12752" /db_xref="UniProtKB/Swiss-Prot:O31464" /translation="MQQILEHIVGIANDLLWSKLLIVLLLSFGIYFTFRLKFLQVRML KEMVRVLREGAASRSKNSISPFQAFCISMAARVGTGNITGIAIAIALGGPGAIFWMWI IAIIGSASSFVESTLAQIYKVKDVNGFRGGPAYYMEKGLNKRWMGALFAVLITLSFGI VFNSVQSNTVSLAFENAFGTNRLTLGLILIAVFGTIIFGGVKRIAKLAESIVVVLAVL YIGVAFFVIFSNITQLPGVLALIVKNAFGFDQAAGGALGAALMQGVRRGIFSNEAGMG SAPNAAATATTSHPVKQGLIQAFGVLTDTLVICTSTAFIILFSDAYHTPGLSGIALTQ ASLSSHVGSWASGFLAILILLFGFCALIGNYYYGETNIGFLNKSKKLIFVYRIGVLAM IVFGCVAKVQLVWDLADLFMGLMVIVNLIAIFLLSKVVFTALKDYTRQKKAGKDPVFY KDVLKNHNGIECWPVSDTKTDTHNKQIS*" gene complement(262732..264168) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" downshifts complement(262747) /Source="Nicolas_upshifts" /id="D94" /incds=0 /nref=3 /ntot=3 /MaxReadThrough="0.598370000000001" /MaxDrop="4.3935" /score="-7.90227391" /energy="-11.4" /TU="NA" /idTUdmin="U174" /TUdmin="-1078" /isTUend="FALSE" CDS complement(264191..265174) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15995196, 18459799, 20050917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995196, 18459799, 20050917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutaminase" /protein_id="NP_388125.1" /db_xref="EnsemblGenomes-Gn:BSU02430" /db_xref="EnsemblGenomes-Tr:CAB12037" /db_xref="GOA:O31465" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="PDB:1MKI" /db_xref="PDB:2OSU" /db_xref="PDB:3AGF" /db_xref="PDB:3BRM" /db_xref="SubtiList:BG12753" /db_xref="UniProtKB/Swiss-Prot:O31465" /translation="MKELIKEHQKDINPALQLHDWVEYYRPFAANGQSANYIPALGKV NDSQLGICVLEPDGTMIHAGDWNVSFTMQSISKVISFIAACMSRGIPYVLDRVDVEPT GDAFNSIIRLEINKPGKPFNPMINAGALTIASILPGESAYEKLEFLYSVMETLIGKRP RIHEEVFRSEWETAHRNRALAYYLKETNFLEAEVEETLEVYLKQCAMESTTEDIALIG LILAHDGYHPIRHEQVIPKDVAKLAKALMLTCGMYNASGKYAAFVGVPAKSGVSGGIM ALVPPSARREQPFQSGCGIGIYGPAIDEYGNSLTGGMLLKHMAQEWELSIF*" gene complement(264191..265174) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" promotor_-10 complement(265268..265285) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 265273..265292 /Source="Nicolas_upshift_promotors" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(265275) /Source="Nicolas_upshifts" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts 265279 /Source="Nicolas_upshifts" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(265301..265308) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 265476..266708 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196, 17001076, 21435182, 23461034, 25691471; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [GlnL] forglutamine degradation" /protein_id="NP_388126.2" /db_xref="EnsemblGenomes-Gn:BSU02440" /db_xref="EnsemblGenomes-Tr:CAB12038" /db_xref="GOA:P40758" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10871" /db_xref="UniProtKB/Swiss-Prot:P40758" /translation="MLITVPLAGELKFYPLNEEFRVSFGAPVFFFFLSLLRHVPAVLP GFLTGAAVFIFRVFLELWGGGHNGLTPILYDQASGFFFYMTYACLFSILKANRFRERP IMLGFIGFMIEVVSDCVELTVQFLIFHTVVTPEKITDIAVIAISHTFIVMSFYSVLKL YETQSREKQTRQQHEHMLMIVSNLYEETVHLKKTLKTTEKVTNDSYQLYREMKGKDVQ LSGRILRLAGEIHEVKKDNQRIFAGLSKLISNESLRDYMRASDLLQLVIRMNEKYAEA LGKQIDFYCSIEGEHDEYHVFIVLSIINNLTANAVEAMDEEGMVSLRLRKPNESMVEF QVEDNGPGISEKIGDIVFDPGFTSKYDEFGTPSTGIGLSYVKEIVTELEGDITFDNQQ RGVVFAIRLPVRHLIQKG*" gene 265476..266708 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" CDS 266719..267663 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [GlnJ] for glutamine utilisation" /protein_id="NP_388127.1" /db_xref="EnsemblGenomes-Gn:BSU02450" /db_xref="EnsemblGenomes-Tr:CAB12039" /db_xref="GOA:P40759" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013972" /db_xref="SubtiList:BG10872" /db_xref="UniProtKB/Swiss-Prot:P40759" /translation="MRFFIADDDRAVRSILRQIIEDEDLGEAAGEADDGSQVEGHMLQ FKQIDILLIDLLMPGRDGIETIRQIQNTYSGKIVMISQVEAKEMVGEAYSLGIEYFIH KPINRIEIVTVLQKVKERIELEHSIGAIQHSLSRLVNRTERKARPQQKSDSGLKEAGT FLLSELGMMGEGGAHDLMAVLQYLAEHEQSEPHEKQSPSLKQIFTQVAVRKLGTGASQ TEVNREMKASEQRIRRAIIHSLHHFASLGTTDFSNPKFETYASKFFDFPVVSQKMKEL QSKDAKPLAPARINMKKFIHVFFLEAKLLHETMKQRRI*" gene 266719..267663 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" downshifts 267640 /Source="Nicolas_upshifts" /id="D95" /incds=0 /nref=45 /ntot=191 /MaxReadThrough="1.43757" /MaxDrop="3.64091" /score="2.73020459" /energy="-6.2" /TU="NA" /idTUdmin="U177" /TUdmin="-484" /isTUend="FALSE" promotor_-35 267760..267767 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 267772..267889 /Source="Nicolas_S_feature" /locus_tag="new_267772_267889" /HighExp="Sw, BC, M40t90, Etha, MG-0.2, HiTm, HiOs, G135, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S94" upshifts 267772 /Source="Nicolas_upshifts" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" promotor_-10 267781..267800 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 267890..268816 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" /EC_number="4.2.1.41" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5-dehydro-4-deoxyglucarate dehydratase" /protein_id="NP_388128.2" /db_xref="EnsemblGenomes-Gn:BSU02460" /db_xref="EnsemblGenomes-Tr:CAB12040" /db_xref="GOA:P42235" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017655" /db_xref="SubtiList:BG11158" /db_xref="UniProtKB/Swiss-Prot:P42235" /translation="MSRIRKAPAGILGFPVAPFNTQGKLEEEALFQNIEFLLNEGLEA IFIACGSGEFQSLSQKEYEQMVEVAVSAAGGKVPVYTGVGGNLSTALDWAQLSEKKGA DGYLILPPYLVHGEQEGLYQYAKTIIESTDLNAILYQRDNAVLSVEQIKRLTECEQLV GVKDGVGNMDLNINLVYTIGDRLGWLNGMPMAEVTMPAYLPIGFHSYSSAISNYIPHI SRMFYDALKNGNDELVKELYRHVILPINDIRKQRKGYAVSLIKAGMEIMGLNVRNTAR PPVGPVEKDHYQQLEAILKQAADRFPKKAATV*" gene 267890..268816 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" CDS 268846..270312 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" /EC_number="1.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674, 17202142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,5-dioxovalerate dehydrogenase (alpha-ketoglutaric semialdehyde dehydrogenase)" /protein_id="NP_388129.1" /db_xref="EnsemblGenomes-Gn:BSU02470" /db_xref="EnsemblGenomes-Tr:CAB12041" /db_xref="GOA:P42236" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11159" /db_xref="UniProtKB/Swiss-Prot:P42236" /translation="MSVITEQNTYLNFINGEWVKSQSGDMVKVENPADVNDIVGYVQN STAEDVERAVTAANEAKTAWRKLTGAERGQYLYKTADIMEQRLEEIAACATREMGKTL PEAKGETARGIAILRYYAGEGMRKTGDVIPSTDKDALMFTTRVPLGVVGVISPWNFPV AIPIWKMAPALVYGNTVVIKPATETAVTCAKIIACFEEAGLPAGVINLVTGPGSVVGQ GLAEHDGVNAVTFTGSNQVGKIIGQAALARGAKYQLEMGGKNPVIVADDADLEAAAEA VITGAFRSTGQKCTATSRVIVQSGIYERFKEKLLQRTKDITIGDSLKEDVWMGPIASK NQLDNCLSYIEKGKQEGASLLIGGEKLENGKYQNGYYVQPAIFDNVTSEMTIAQEEIF GPVIALIKVDSIEEALNIANDVKFGLSASIFTENIGRMLSFIDEIDAGLVRINAESAG VELQAPFGGMKQSSSHSREQGEAAKDFFTAIKTVFVKP*" gene 268846..270312 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" CDS 270396..271763 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12044674, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucarate transporter" /protein_id="NP_388130.2" /db_xref="EnsemblGenomes-Gn:BSU02480" /db_xref="EnsemblGenomes-Tr:CAB12042" /db_xref="GOA:P42237" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11160" /db_xref="UniProtKB/Swiss-Prot:P42237" /translation="MKKDFASVTPAGKKTSVRWFIVFMLFLVTSINYADRATLSITGD SVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQ GAIGFFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQY FAIVIFSPLMGWLTHSFGWHSVFVVMGIAGILLAVIWLKTVYEPKKHPKVNEAELAYI EQGGGLISMDDSKSKQETESKWPYIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVY LVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGRSLTFARKVPIIAGMLL SCSMIVCNYTDSAWLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGN IASITTPIIIGYIVNATGSFNGALVFVGANAIAAILSYLLLVGPIKRVVLKKQEQDPD QSLPV*" gene 270396..271763 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" CDS 271800..273167 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" /EC_number="4.2.1.40" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772161, 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucarate dehydratase" /protein_id="NP_388131.2" /db_xref="EnsemblGenomes-Gn:BSU02490" /db_xref="EnsemblGenomes-Tr:CAB12043" /db_xref="GOA:P42238" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR017653" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR034598" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11161" /db_xref="UniProtKB/Swiss-Prot:P42238" /translation="MSSPIQEQVQKEKRSNIPSISEMKVIPVAGHDSMLLNLSGAHSP FFTRNIVILTDSSGNQGVGEVPGGEHIRRTLELSEPLVVGKSIGAYQAILQTVRKQFG DQDRGGRGNQTFDLRTTVHAVTALEAALLDLLGKFLQEPVAALLGEGKQRDEVKMLGY LFYIGDRNRTTLPYQSDEQSDCAWFRLRHEEALTPEAIVRLAESAQERYGFQDFKLKG GVLRGEEEIEAVTALSKRFPEARITLDPNGAWSLEEAIALCKGKQDVLAYAEDPCGDE NGYSAREVMAEFRRATGLPTATNMIATDWREMGHAIQLHAVDIPLADPHFWTMQGSVR VAQMCHDWGLTWGSHSNNHFDISLAMFTHVAAAAPGRITAIDTHWIWQDGQRLTKQPF EISSGCVKVPDKPGLGVDIDMEQVEKAHEIYRKMNLGARNDAIPMQFLISNWEFDRKR PCLVR*" gene 271800..273167 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" promotor_-35 273181..273188 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-35" promotor_-10 273203..273220 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-10" upshifts 273206 /Source="Nicolas_upshifts" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" CDS 273237..273938 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12044674" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_388132.2" /db_xref="EnsemblGenomes-Gn:BSU02500" /db_xref="EnsemblGenomes-Tr:CAB12044" /db_xref="GOA:P42239" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11162" /db_xref="UniProtKB/Swiss-Prot:P42239" /translation="MYEGLEDLKVDTVNRKTLAKQVIERIVHLLSSGQLRAGDKLPTE MELMDILHVSRPVLREALSSLETLGVITRKTRGGTYFNDKIGMQPFSVMLALATDNLP AIIEARMALELGLVTIAAEKINEEELQRLQKTIDDIANSTDNHYGEADKEFHRIIALS ANNPVVEGMIQSLLITHAKIDSQIPYRERDVTVEYHKKIYDALAKRDPYKAHYHMYEH LKFVRDKILKGMDEK*" gene 273237..273938 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" downshifts 273888 /Source="Nicolas_upshifts" /id="D96" /incds=0 /nref=1 /ntot=35 /MaxReadThrough="3.59234" /MaxDrop="2.3923" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1694" /isTUend="FALSE" downshifts 273932 /Source="Nicolas_upshifts" /id="D97" /incds=0 /nref=1 /ntot=82 /MaxReadThrough="3.21794" /MaxDrop="2.49226" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1650" /isTUend="FALSE" CDS 274029..275561 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" /EC_number="4.2.1.42" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772162; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-galactarate dehydratase" /protein_id="NP_388133.2" /db_xref="EnsemblGenomes-Gn:BSU02510" /db_xref="EnsemblGenomes-Tr:CAB12045" /db_xref="GOA:P42240" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR017654" /db_xref="SubtiList:BG11163" /db_xref="UniProtKB/Swiss-Prot:P42240" /translation="MAMNLRKNQAPLYIKVHEIDNTAIIVNDGGLPKGTVFSCGLVLE EDVPQGHKVALTDLNQGDEIVRYGEVIGFADETIKRGSWIREALVRMPAPPALDDLPL ANRVPQPRPPLEGYTFEGYRNADGSAGTKNILGITTSVQCVVGVLDYAVKRIKEELLP KYPNVDDVVPLHHQYGCGVAINAPDAVIPIRTIQNLAKHPNFGGEVMVIGLGCEKLLP ERIASENDDDILSLQDHRGFAAMIQSILEMAEERLIRLNSRTRVSCPVSDLVIGLQCG GSDAFSGVTANPAVGYAADLLVRAGATVLFSEVTEVRDAIHLLTPRAVSEEVGQSLIK EMKWYDSYLRRGDADRSANPSPGNKKGGLSNVVEKALGSVAKSGTSPISGVLGPGERA KQKGLLFAATPASDFVCGTLQLAAGMNLQVFTTGRGTPYGLAAAPVLKVSTRHSLSEH WADLIDINAGRIATGEASIEDVGWEIFRTILDVASGRKQTWADRWGLHNDLCLFNPAP VT*" gene 274029..275561 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" promotor_-35 275573..275576 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 275591..275610 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 275603..275837 /Source="Nicolas_S_feature" /locus_tag="new_275603_275837" /HighExp="LoTm, Sw, BC, BI, B60, B36, T3.30H, T5.0H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.50265400000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S95" upshifts 275603 /Source="Nicolas_upshifts" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" CDS 275838..276758 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_388134.1" /db_xref="EnsemblGenomes-Gn:BSU02520" /db_xref="EnsemblGenomes-Tr:CAB12046" /db_xref="GOA:P42242" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG11165" /db_xref="UniProtKB/Swiss-Prot:P42242" /translation="MTNLNEKQLITEIVGLARSQGLTVHSENAQLNETGMDFQVVFAK DDTGMPWVLRKPRRSDVVERASAEGITLAFLRANLTADVPDWRIHTPELIAYPMLKGT PAAGIDLEQKQYVWNMDHQPPSDDFVRTLADILAELHGTDQISAGQSGIEVIRPEDFR QMTADSMVDVKNKLGVSTTLWERWQKWVDDDAYWPGFSSLIHGDLHPPHILIDQNGRV TGLLDWTEAKVADPAKDFVLYQTIFGEKETARLLEYYDQAGGRIWAKMQEHISEMQAA YPVEIAKLALQTQQEEHINMALEALGVTSD*" gene 275838..276758 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" promotor_-35 276760..276767 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 276782..276801 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 276792 /Source="Nicolas_upshifts" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" misc_RNA 276815..277062 /gene="tboW" /locus_tag="BSU_misc_RNA_6" /product="T-box riboswitch specific of tryptophan tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 10706627, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 10706627, 12165569, 12547201; Product type n: RNA" gene 276815..277062 /gene="tboW" /locus_tag="BSU_misc_RNA_6" downshifts 277031 /Source="Nicolas_upshifts" /id="D98" /incds=0 /nref=225 /ntot=264 /MaxReadThrough="2.36361" /MaxDrop="6.52913" /score="36.5571172" /energy="-16.6" /TU="NA" /idTUdmin="U179" /TUdmin="-3" /isTUend="TRUE" CDS 277160..277321 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-TRAP regulator" /protein_id="NP_388135.1" /db_xref="EnsemblGenomes-Gn:BSU02530" /db_xref="EnsemblGenomes-Tr:CAB12047" /db_xref="GOA:O31466" /db_xref="InterPro:IPR031538" /db_xref="InterPro:IPR036410" /db_xref="PDB:2BX9" /db_xref="PDB:2KO8" /db_xref="PDB:2ZP8" /db_xref="PDB:2ZP9" /db_xref="SubtiList:BG12776" /db_xref="UniProtKB/Swiss-Prot:O31466" /translation="MVIATDDLEVACPKCERAGEIEGTPCPACSGKGVILTAQGYTLL DFIQKHLNK*" gene 277160..277321 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" promotor_no_box 277238..277338 /Source="Nicolas_upshift_promotors" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 277298 /Source="Nicolas_upshifts" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 277342..278280 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10706627, 15063849, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative tryptophan or indole exporter" /protein_id="NP_388136.1" /db_xref="EnsemblGenomes-Gn:BSU02540" /db_xref="EnsemblGenomes-Tr:CAB12048" /db_xref="GOA:P42243" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG11166" /db_xref="UniProtKB/Swiss-Prot:P42243" /translation="MRAEEQSKIREAAAGTIFLLIGTVCFASKSIWIKWAYQMGAEPD AVLLYRQLLAVPLFWLIFLIYRPPMPDGKKKGDLWKACGAGVFCFFLSPLLDFIGLNH VSAMVERILLMSYPLFVFGFTACRDRKMSSIQDLFAVLAVMFGLFLALGGWNAELFQA NMIGAVFILLSSAVYAGYLVLSGHLVHQIGGIRLNAYGMTAAGAAMMLYTGIKSAAGM NTPMAAYPLSMYGLFAVIAVVTTVIPFVLMLEGIKRIGAQRAAAISMAGPILTIFYGA LFLGERLGLIQVIGCGGVFFVITGMEYRKLKTGKKE*" gene 277342..278280 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" downshifts 277386 /Source="Nicolas_upshifts" /id="D99" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="3.05417" /MaxDrop="3.72787" /score="0.773303272" /energy="-9" /TU="NA" /idTUdmin="U181" /TUdmin=0 /isTUend="TRUE" misc_feature 278303..278322 /Source="Nicolas_upshift_promotors" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 278308..278376 /Source="Nicolas_S_feature" /locus_tag="new_278308_278376" /HighExp="C90, dia5, Lbtran, Lbexp, LBGexp, SMM, dia0, dia15, BMM, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S96" upshifts 278308 /Source="Nicolas_upshifts" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" CDS 278377..279057 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YcbM]" /protein_id="NP_388137.2" /db_xref="EnsemblGenomes-Gn:BSU02550" /db_xref="EnsemblGenomes-Tr:CAB12049" /db_xref="GOA:P42244" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11167" /db_xref="UniProtKB/Swiss-Prot:P42244" /translation="MLVEDDHSISEMVDHYLTKEGFGIVHAFDGEEGIRLFQQGSYDL VLLDIMLPKLNGMDFLKIIREKSNIPVLMISAKDGDVDKALGLGFGADDYIAKPFSMI ELTARVKAAIRRATQYSAEEPAVNKVIRIHQLAIDIDNVSVLKNGEPLQLTSTEWQLL CLFASNPKKVFTKEQIYRSVWNEEYFDDQNIINVHMRRLREKIEDDPSSPQYIKTLWG IGYKLGEF*" gene 278377..279057 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" CDS 279059..279994 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YcbL]" /protein_id="NP_388138.2" /db_xref="EnsemblGenomes-Gn:BSU02560" /db_xref="EnsemblGenomes-Tr:CAB12050" /db_xref="GOA:P42245" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11168" /db_xref="UniProtKB/Swiss-Prot:P42245" /translation="MTVLWVAAVIALACLNVIQFIMKKKRDGNLAYTADQLSYMLSRD SAGQILLPTDDHALKDLLVNINLIVENRQQISAQFAKTEQSMKRMLTNMSHDLKTPLT VILGYIEAIQSDPNMPDEERERLLGKLRQKTNELIQMINSFFDLAKLESEDKEIPITK VHMNDICKRNILHYYDAVQSKGFQAAIDIPDTPVYAQANEEALDRILQNLLSNAIQYG AAGKLIGLTLSYDERNIAITVWDRGKGISETDQQRVFERLYTLEESRNKAFQGSGLGL TITKRLTEKMGGIISVQSKPYERTAFTITLKRMTY*" gene 279059..279994 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" CDS 280086..281009 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388139.2" /db_xref="EnsemblGenomes-Gn:BSU02570" /db_xref="EnsemblGenomes-Tr:CAB12051" /db_xref="GOA:P42246" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11169" /db_xref="UniProtKB/Swiss-Prot:P42246" /translation="MTYIVQTNGLTKTYQGKEVVSNVSMHIKKGEIYGFLGPNGAGKT TIMKMLTSLVKPTSGEIIILGNKFTHTSYEVLGNIGSMIEYPIFYENLTAEENLDLHC EYMGYHNKKAIQEVLDMVNLKQIDKKPVKTFSLGMKQRLGIARAILTKPDLLILDEPV NGLDPLGIKKIRQLFQVLSKEYGMTLLISSHLLGEIEQIADTIGVIRDGRLLEEVSME DVRGQNTEYIELVTPNQTRACFVLEKELQLTNFKILNEKTIRIYEAEASQAAISKALI LNDVDIESMNKKYTSLEDYFIKLINGNSISA*" gene 280086..281009 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" S_feature complement(280556..281740) /Source="Nicolas_S_feature" /locus_tag="new_280556_281740_c" /HighExp="Etha, Sw, Gly, B36, LoTm, B60, GM 150, Salt, C30, ferm" /AntisenseName="ycbO" /AntisenseCor="-0.38911425676406203" /AntisenseRegPval="-10.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S97" CDS 281028..281714 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven exporter" /protein_id="NP_388140.3" /db_xref="EnsemblGenomes-Gn:BSU02580" /db_xref="EnsemblGenomes-Tr:CAB12052" /db_xref="GOA:P42247" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11170" /db_xref="UniProtKB/Swiss-Prot:P42247" /translation="MNLIRIELRKMKMGWYIRGALIANVIIMGFMWLISYSEKADGGV SFQSTDEAFLIIGTFVRAVFIVFGAVLIVKLVISEYKNKTILVMFTYPISRKKLLTAK LMIAGGLTFITILLSNILIAAGFFWLNSICHFIPGELTSEIISQQAVKMAVFAFGAAG TSLVPIFFGMRRHSVPATIISSVVIVMLISSTSPGFSISSVVYIPLSLAAFGLFFSYM AIRNADKQDA*" gene 281028..281714 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" CDS complement(281675..281809) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513940.1" /translation="MARSIILKQEQTHNGKAGADSIGLLYILGAFVYASCLSAFLIAM *" gene complement(281675..281809) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" downshifts 281709 /Source="Nicolas_upshifts" /id="D100" /incds=0 /nref=8 /ntot=120 /MaxReadThrough="1.13131" /MaxDrop="3.44039" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin="-1166" /isTUend="FALSE" CDS complement(281769..282155) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22582280; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative inner integral membrane protein" /protein_id="NP_388141.1" /db_xref="EnsemblGenomes-Gn:BSU02590" /db_xref="EnsemblGenomes-Tr:CAB12053" /db_xref="GOA:P42248" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG11171" /db_xref="UniProtKB/Swiss-Prot:P42248" /translation="MTHVKALAIKGIMTIIVLYLVLGLGFGFTFGDTLLMTIVLGVIS YLLGDLYVLPKWNNMIATLADFGLAFLVIWLMGMPLSMGMTGGEVALAALFGAIVMAI GEYCFHFYMMSKEIGKKHYLETRTDS*" gene complement(281769..282155) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" downshifts complement(281785) /Source="Nicolas_upshifts" /id="D101" /incds=0 /nref=148 /ntot=217 /MaxReadThrough="6.64196" /MaxDrop="7.40353" /score="13.8182557" /energy="-15.6" /TU="U183" /idTUdmin="U185" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(282181..282199) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(282200) /Source="Nicolas_upshifts" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" promotor_-35 complement(282213..282219) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(282233..283231) /Source="Nicolas_S_feature" /locus_tag="new_282233_283231_c" /HighExp="GM 150, T0.30H, C30, T1.30H, T1.0H, T-0.40H, T-3.40H, T2.0H, T2.30H, T-4.40H" /AntisenseName="cwlJ" /AntisenseCor="0.11463160303596701" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S98" downshifts complement(282276) /Source="Nicolas_upshifts" /id="D102" /incds=0 /nref=3 /ntot=10 /MaxReadThrough="5.23914" /MaxDrop="3.14515" /score="13.8182557" /energy="-15.6" /TU="U185,U187" /idTUdmin="U185" /TUdmin="-491" /isTUend="FALSE" promotor_-35 282412..282417 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 282431 /Source="Nicolas_upshifts" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" promotor_-10 282433..282451 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(282445) /Source="Nicolas_upshifts" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" promotor_-10 complement(282447..282461) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(282467) /Source="Nicolas_upshifts" /id="D103" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="5.64474" /MaxDrop="3.76775" /score="13.8182557" /energy="-15.6" /TU="U187" /idTUdmin="U185" /TUdmin="-682" /isTUend="FALSE" promotor_-35 complement(282469..282473) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 282469..282897 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore cortex cell wall hydrolase" /protein_id="NP_388142.2" /db_xref="EnsemblGenomes-Gn:BSU02600" /db_xref="EnsemblGenomes-Tr:CAB12054" /db_xref="GOA:P42249" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG11172" /db_xref="UniProtKB/Swiss-Prot:P42249" /translation="MAVVRATSADVDLMARLLRAEAEGEGKQGMLLVGNVGINRLRAN CSDFKGLRTIRQMIYQPHAFEAVTHGYFYQRARDSERALARRSINGERRWPAKFSLWY FRPQGDCPAQWYNQPFVARFKSHCFYQPTAETCENVYNTF*" gene 282469..282897 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" downshifts 282876 /Source="Nicolas_upshifts" /id="D104" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.30044" /MaxDrop="5.89045" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin=1 /isTUend="TRUE" promotor_-35 282942..282948 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 282961..282980 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 282963 /Source="Nicolas_upshifts" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" CDS 283003..283734 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388143.2" /db_xref="EnsemblGenomes-Gn:BSU02610" /db_xref="EnsemblGenomes-Tr:CAB12055" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR019303" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG11173" /db_xref="UniProtKB/Swiss-Prot:P42250" /translation="MATIDLQKKSVKIVLEKKQLTKVTARVGLVLDITGSMRPLYKNG TVQNVVERILAVADQFDDNGLLDVWVYDNEFSRLKPVSEKDFSGYVDREILNNDRLHK FGRNDEPPVMKDVLRKYVTEEPSSYPAFIVFINDGGCKKSIKPIIEASSDKPVFWQFV GIGNGNFDFLNKLDTLEGRVIDNTNFLHIEEIDRISDDELYDALLAEFPFWLKEAKEK GIVREQEPPAEKPKKKGFFSRLFSK*" gene 283003..283734 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" promotor_-10 complement(283205..283224) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(283231) /Source="Nicolas_upshifts" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" promotor_-35 complement(283238..283245) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 283652 /Source="Nicolas_upshifts" /id="D105" /incds=1 /nref=9 /ntot=148 /MaxReadThrough="1.70712" /MaxDrop="3.61288" /score="25.6672471" /energy="-14.1" /TU="NA" /idTUdmin="U186" /TUdmin=7 /isTUend="TRUE" CDS 283816..283992 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097673.1" /db_xref="EnsemblGenomes-Gn:BSU02619" /db_xref="EnsemblGenomes-Tr:CAX52543" /db_xref="UniProtKB/Swiss-Prot:C0H3T2" /translation="MGGLQTTGYAENASFSQLSACFSSRLVREDLFLMFSAYNQFTLL HSRLTMISYNGDDQ*" gene 283816..283992 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" promotor_-35 283944..283950 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 283957..283974 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 283968 /Source="Nicolas_upshifts" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" CDS 284011..285762 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted phosphodiesterase (endo-hydrolysis at non-specific sites throughout the cell wall teichoic acid polymer)" /protein_id="NP_388144.2" /db_xref="EnsemblGenomes-Gn:BSU02620" /db_xref="EnsemblGenomes-Tr:CAB12056" /db_xref="GOA:P42251" /db_xref="InterPro:IPR008963" /db_xref="InterPro:IPR018946" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR032093" /db_xref="PDB:2YEQ" /db_xref="SubtiList:BG11174" /db_xref="UniProtKB/Swiss-Prot:P42251" /translation="MAYDSRFDEWVQKLKEESFQNNTFDRRKFIQGAGKIAGLSLGLT IAQSVGAFEVNAAPNFSSYPFTLGVASGDPLSDSVVLWTRLAPDPLNGGGMPKQAVPV KWEVAKDEHFRKIVRKGTEMAKPSLAHSVHVEADGLEPNKVYYYRFKTGHELSPVGKT KTLPAPGANVPQMTFAFASCQQYEHGYYTAYKHMAKEKLDLVFHLGDYIYEYGPNEYV SKTGNVRTHNSAEIITLQDYRNRHAQYRSDANLKAAHAAFPWVVTWDDHEVENNYANK IPEKGQSVEAFVLRRAAAYQAYYEHMPLRISSLPNGPDMQLYRHFTYGNLASFNVLDT RQYRDDQANNDGNKPPSDESRNPNRTLLGKEQEQWLFNNLGSSTAHWNVLAQQIFFAK WNFGTSASPIYSMDSWDGYPAQRERVINFIKSKNLNNVVVLTGDVHASWASNLHVDFE KTSSKIFGAEFVGTSITSGGNGADKRADTDQILKENPHIQFFNDYRGYVRCTVTPHQW KADYRVMPFVTEPGAAISTRASFVYQKDQTGLRKVSSTTIQGGVKQSDEVEEDRFFSH NKAHEKQMIKKRAKITN*" gene 284011..285762 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" promotor_-10 complement(284065..284080) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(284071) /Source="Nicolas_upshifts" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(284093..284102) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 285775..285987 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867413, 15554971, 16678787, 19049517, 21479530, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867413, 15554971, 16678787, 19049517, 21479530, 27984091; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388145.2" /db_xref="EnsemblGenomes-Gn:BSU02630" /db_xref="EnsemblGenomes-Tr:CAB12057" /db_xref="GOA:O31467" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR003998" /db_xref="InterPro:IPR006312" /db_xref="PDB:2L16" /db_xref="SubtiList:BG12777" /db_xref="UniProtKB/Swiss-Prot:O31467" /translation="MFSNIGIPGLILIFVIALIIFGPSKLPEIGRAAGRTLLEFKSAT KSLVSGDEKEEKSAELTAVKQDKNAG*" gene 285775..285987 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" S_feature 285988..286047 /Source="Nicolas_S_feature" /locus_tag="new_285988_286047" /HighExp="LPhT, BI, Paraq, C90, H2O2, M40t90, C30, M0t90, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0569" /TUlongSig="NA" /TUlongPSig="NA" /label="S99" CDS 286048..286776 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16698798, 19049517, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16698798, 19049517, 27984091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388146.2" /db_xref="EnsemblGenomes-Gn:BSU02640" /db_xref="EnsemblGenomes-Tr:CAB12058" /db_xref="GOA:P42252" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG11175" /db_xref="UniProtKB/Swiss-Prot:P42252" /translation="MDKKETHLIGHLEELRRRIIVTLAAFFLFLITAFLFVQDIYDWL IRDLDGKLAVLGPSEILWVYMMLSGICAIAASIPVAAYQLWRFVAPALTKTERKVTLM YIPGLFALFLAGISFGYFVLFPIVLSFLTHLSSGHFETMFTADRYFRFMVNLSLPFGF LFEMPLVVMFLTRLGILNPYRLAKARKLSYFLLIVVSILITPPDFISDFLVMIPLLVL FEVSVTLSAFVYKKRMREETAAAA*" gene 286048..286776 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" downshifts complement(286056) /Source="Nicolas_upshifts" /id="D106" /incds=0 /nref=4 /ntot=146 /MaxReadThrough="1.2763" /MaxDrop="3.13944" /score="-9.00478071" /energy="-8.5" /TU="NA" /idTUdmin="U190" /TUdmin="-6" /isTUend="TRUE" CDS complement(286773..287420) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" /EC_number="3.4.19.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1362573, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1362573, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrrolidone-carboxylate (pyroglutamate) peptidase" /protein_id="NP_388147.1" /db_xref="EnsemblGenomes-Gn:BSU02650" /db_xref="EnsemblGenomes-Tr:CAB12059" /db_xref="GOA:P28618" /db_xref="InterPro:IPR000816" /db_xref="InterPro:IPR016125" /db_xref="InterPro:IPR029762" /db_xref="InterPro:IPR033693" /db_xref="InterPro:IPR033694" /db_xref="InterPro:IPR036440" /db_xref="SubtiList:BG10873" /db_xref="UniProtKB/Swiss-Prot:P28618" /translation="MRKKVLITGFDPFDKETVNPSWEAAKRLNGFETEEAIITAEQIP TVFRSALDTLRQAIQKHQPDIVICVGQAGGRMQITPERVAINLADARIPDNEGHQPID EEISPDGPAAYWTRLPVKRMTAKMKEHGIPAAVSYTAGTFVCNYLFYGLMDHISRTSP HIRGGFIHIPYIPQQTIDKTAPSLSLDTIVRALRIAAVTAAQYDEDVKSPGGTLH*" gene complement(286773..287420) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" promotor_-10 complement(287435..287454) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 287448..287454 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(287449) /Source="Nicolas_upshifts" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" promotor_-10 287469..287488 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(287469..287473) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 287471 /Source="Nicolas_upshifts" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" CDS 287499..288611 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase (PLP-dependent)" /protein_id="NP_388148.2" /db_xref="EnsemblGenomes-Gn:BSU02660" /db_xref="EnsemblGenomes-Tr:CAB12060" /db_xref="GOA:P42253" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG11176" /db_xref="UniProtKB/Swiss-Prot:P42253" /translation="MEHLPEQYRQLFPTLQTHTMLASCSQSALAEPVSRAIQDYYDSL LYKGTNWKEAIEKTEFARNEFAKLIGAEPDEVAIVPSVSDALVSVASSLTAFGKKHVV YTDMDFPAVPHVWQAHSDYTVSVIPSIDGVLPLEQYETHISDETVLTCVPHVHYRDGY VQDIKAIAEISQRKGSLLFVDAYQSAGHIPIDVKEWGVDMLAAGTRKYLLGIPGVAFL YVRKELADALKPKASAWFGRESGFDGAYAKVARRFQTGTPAFISVYAAAAALSLLNHI GVSHIRDHVKTICADAVQYAAEKGLQLAAAQGGIQPGMVAIRDERASETAGLLKKKKV ICAPRENVIRLAPHFYNTKEEMRHAIDEIAAKTIHK*" gene 287499..288611 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" upshifts complement(287845) /Source="Nicolas_upshifts" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(287848..287867) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(287883..287887) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 288605 /Source="Nicolas_upshifts" /id="D107" /incds=0 /nref=45 /ntot=226 /MaxReadThrough="1.10091" /MaxDrop="4.52742" /score="6.75687898" /energy="-14" /TU="NA" /idTUdmin="U191" /TUdmin=814 /isTUend="FALSE" CDS complement(288653..290092) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 17483215; Product type t: transporter" /codon_start=1 /transl_table=11 /product="flavonoid efflux transporter; drug-export protein" /protein_id="NP_388149.1" /db_xref="EnsemblGenomes-Gn:BSU02670" /db_xref="EnsemblGenomes-Tr:CAB12061" /db_xref="GOA:O35018" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12613" /db_xref="UniProtKB/Swiss-Prot:O35018" /translation="MILETTAKASQQYKVMPIMISLLLAGFIGMFSETALNIALTDLM KELNITAATVQWLTTGYLLVLGILVPVSGLLLQWFTTRQLFTVSLIFSILGTFIAALA PSFSFLLAARIVQALGTGLLLPLMFNTILVIFPPHKRGAAMGTIGLVIMFAPAIGPTF SGLVLEHLNWHWIFWISLPFLVLALVFGIAYMQNVSETTKPKIDVLSIILSTIGFGGI VFGFSNAGEGSGGWSSPTVIVSLIVGVVGLILFSIRQLTMKQPMMNLRAFKYPMFILG VIMVFICMMVILSSMLLLPMYLQGGLVLTAFASGLVLLPGGILNGFMSPVTGRLFDKY GPKWLVIPGFVIVTVVLWFFSNVTTTSTAVLIIILHTCLMIGISMIMMPAQTNGLNQL PREFYPDGTAIMNTLQQMAGAIGTAVAVSIMAAGQHDYMSTVKNPADPAVIPQALTAG VQHAFVFAMIVAIIGLIGAFFMKRVKVDH*" gene complement(288653..290092) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" downshifts complement(288660) /Source="Nicolas_upshifts" /id="D108" /incds=0 /nref=162 /ntot=245 /MaxReadThrough="0.65833" /MaxDrop="6.75228" /score="18.3484535" /energy="-14" /TU="U193" /idTUdmin="U193" /TUdmin="-23" /isTUend="FALSE" CDS complement(290132..290698) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12718394, 15317768, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12718394, 15317768, 17483215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of lmrAB and yxaGH operons (flavonoid and antibiotic resistance)" /protein_id="NP_388150.1" /db_xref="EnsemblGenomes-Gn:BSU02680" /db_xref="EnsemblGenomes-Tr:CAB12062" /db_xref="GOA:O34619" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12612" /db_xref="UniProtKB/Swiss-Prot:O34619" /translation="MSYGDSREKILSAATRLFQLQGYYGTGLNQIIKESGAPKGSLYY HFPGGKEQLAIEAVNEMKEYIRQKIADCMEACTDPAEGIQAFLKELSCQFSCTEDIEG LPVGLLAAETSLKSEPLREACHEAYKEWASVYEEKLRQTGCSESRAKEASTVVNAMIE GGILLSLTAKNSTPLLHISSCIPDLLKR*" gene complement(290132..290698) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" promotor_-10 complement(290736..290755) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(290750) /Source="Nicolas_upshifts" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" promotor_-35 complement(290770..290777) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 290852..290858 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 290874..290891 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 290880 /Source="Nicolas_upshifts" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" CDS 290915..292042 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" /EC_number="3.5.1.1" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11914346, 17686772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346, 17686772; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-asparaginase 2 (putative lipoprotein)" /protein_id="NP_388151.1" /db_xref="EnsemblGenomes-Gn:BSU02690" /db_xref="EnsemblGenomes-Tr:CAB12063" /db_xref="GOA:O34482" /db_xref="InterPro:IPR004550" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG12755" /db_xref="UniProtKB/Swiss-Prot:O34482" /translation="MKKQRMLVLFTALLFVFTGCSHSPETKESPKEKAQTQKVSSASA SEKKDLPNIRILATGGTIAGADQSKTSTTEYKAGVVGVESLIEAVPEMKDIANVSGEQ IVNVGSTNIDNKILLKLAKRINHLLASDDVDGIVVTHGTDTLEETAYFLNLTVKSDKP VVIVGSMRPSTAISADGPSNLYNAVKVAGAPEAKGKGTLVVLNDRIASARYVTKTNTT TTDTFKSEEMGFVGTIADDIYFNNEITRKHTKDTDFSVSNLDELPQVDIIYGYQNDGS YLFDAAVKAGAKGIVFAGSGNGSLSDAAEKGADSAVKKGVTVVRSTRTGNGVVTPNQD YAEKDLLASNSLNPQKARMLLMLALTKTNDPQKIQAYFNEY*" gene 290915..292042 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" downshifts 292015 /Source="Nicolas_upshifts" /id="D109" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="1.70459" /MaxDrop="4.27333" /score="23.2201078" /energy="-7.6" /TU="NA" /idTUdmin="U194" /TUdmin=0 /isTUend="TRUE" promotor_-35 292139..292145 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 292159..292178 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 292159 /Source="Nicolas_upshifts" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" CDS 292205..292843 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8396026, 15812018, 18053819, 11029590, 24827611, 28963005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8396026, 15812018, 18053819, 11029590, 24827611, 28963005; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="secreted alkaliphilic lipase" /protein_id="NP_388152.1" /db_xref="EnsemblGenomes-Gn:BSU02700" /db_xref="EnsemblGenomes-Tr:CAB12064" /db_xref="GOA:P37957" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="PDB:1I6W" /db_xref="PDB:1ISP" /db_xref="PDB:1R4Z" /db_xref="PDB:1R50" /db_xref="PDB:1T2N" /db_xref="PDB:1T4M" /db_xref="PDB:2QXT" /db_xref="PDB:2QXU" /db_xref="PDB:3D2A" /db_xref="PDB:3D2B" /db_xref="PDB:3D2C" /db_xref="PDB:3QMM" /db_xref="PDB:3QZU" /db_xref="PDB:5CRI" /db_xref="PDB:5CT4" /db_xref="PDB:5CT5" /db_xref="PDB:5CT6" /db_xref="PDB:5CT8" /db_xref="PDB:5CT9" /db_xref="PDB:5CTA" /db_xref="PDB:5CUR" /db_xref="SubtiList:BG10679" /db_xref="UniProtKB/Swiss-Prot:P37957" /translation="MKFVKRRIIALVTILMLSVTSLFALQPSAKAAEHNPVVMVHGIG GASFNFAGIKSYLVSQGWSRDKLYAVDFWDKTGTNYNNGPVLSRFVQKVLDETGAKKV DIVAHSMGGANTLYYIKNLDGGNKVANVVTLGGANRLTTGKALPGTDPNQKILYTSIY SSADMIVMNYLSRLDGARNVQIHGVGHIGLLYSSQVNSLIKEGLNGGGQNTN*" gene 292205..292843 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" downshifts 292829 /Source="Nicolas_upshifts" /id="D110" /incds=0 /nref=15 /ntot=117 /MaxReadThrough="4.54554" /MaxDrop="4.10395" /score="23.2201078" /energy="-7.6" /TU="U195" /idTUdmin="U194" /TUdmin=814 /isTUend="FALSE" S_feature 292874..293464 /Source="Nicolas_S_feature" /locus_tag="new_292874_293464" /HighExp="M9-tran, GM 150, LoTm, MG 150, GM 120, aero, T-1.40H, M/G, S2, GM 90" /AntisenseName="yczC" /AntisenseCor="3.5651747957185502E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S100" CDS complement(292881..293264) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_388153.1" /db_xref="EnsemblGenomes-Gn:BSU02710" /db_xref="EnsemblGenomes-Tr:CAB12065" /db_xref="GOA:O31469" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG12778" /db_xref="UniProtKB/Swiss-Prot:O31469" /translation="MELAGFMLRACALLLDVIIAAAVILAAGFTFGDGSAGVIIVAIL MLIVYPLLMPLTNWKGTLGKKIIGLQIVRDETYKKISFPQAIVRYLIAWVHVFSRLIY LTAAFTKKKQTVHDMAAKTIVLKAE*" gene complement(292881..293264) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" downshifts complement(292905) /Source="Nicolas_upshifts" /id="D111" /incds=0 /nref=4 /ntot=94 /MaxReadThrough="0.85389" /MaxDrop="2.7858" /score="15.0330092" /energy="-12.1" /TU="NA" /idTUdmin="U196" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(293294..293313) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(293301) /Source="Nicolas_upshifts" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" promotor_-35 complement(293327..293334) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 293436..293439 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 293455..293474 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 293466 /Source="Nicolas_upshifts" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" CDS 293499..294575 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388154.1" /db_xref="EnsemblGenomes-Gn:BSU02720" /db_xref="EnsemblGenomes-Tr:CAB12066" /db_xref="GOA:O34478" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR007889" /db_xref="InterPro:IPR036915" /db_xref="SubtiList:BG12756" /db_xref="UniProtKB/Swiss-Prot:O34478" /translation="MGKVKRNAPCPCGSGKKYKKCCGSKVVDFPAELAAKEAKQIQED LVEYAFTVHRESISGFINQHDFLSAMDRQTKDISVFNLGIWGIFFHPLAGEKTIFEEY LQKKGDSITRPKTREIVESWQSMTPALLLLKDLKEGIIHFEDVITAKQFEVEMDASNQ DLPPVGSLILGYPIHEAEKAEFFMQFTIFPVKRTEALISKVKKYADAAVKDGKTPEDF MKQEFNNVLFALLAEKDEEPQAEKAEVSTVEWANDLEKETAAAIEEGMSGEEYPTELI PAVIDIWKTFCEKKSPVIRKPEAFAAAVEYYVNAISLNGASVSQAKLAKKYGVSASTI SSRYKEIESTLQDEADRFAQALSS*" gene 293499..294575 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" downshifts 294569 /Source="Nicolas_upshifts" /id="D112" /incds=0 /nref=60 /ntot=248 /MaxReadThrough="1.55048" /MaxDrop="5.18328" /score="33.0000484" /energy="-12.9" /TU="NA" /idTUdmin="U197" /TUdmin=2 /isTUend="TRUE" CDS complement(294615..295571) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [NatR]" /protein_id="NP_388155.1" /db_xref="EnsemblGenomes-Gn:BSU02730" /db_xref="EnsemblGenomes-Tr:CAB12067" /db_xref="GOA:P70954" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR032834" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11997" /db_xref="UniProtKB/Swiss-Prot:P70954" /translation="MITLFQCLYLILFSFICYQGAAAFSHSTAASWLAAALGAAAAGL YIWNTKRVWKHCSSGLCAWIAVIQVMSVGVVLIGTDIMPVLCVIAIFAGCEGLRIGQS ALQARLSDQIDKLTQAEQHANQMLIDVRSRNHDTMKHITAIKSAQPKADTQAYIQNWA DQYSQYDRFLKGENAYVAGVLYDFLEKARASNVSVSLHMHTPLSSLPFSPADQVSLVG NILENALDSAAEAREKAEIKLETSLRSGLYVLTCENSTPGMDPKVLDTIYQSFGRSTK NGAHEGMGTYIIQKLVKGAFGRLDFTYRHPIFRLEIKIPFQK*" gene complement(294615..295571) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" downshifts complement(294643) /Source="Nicolas_upshifts" /id="D113" /incds=0 /nref=1 /ntot=129 /MaxReadThrough="0.86926" /MaxDrop="2.67125" /score="14.02819" /energy="-12.9" /TU="NA" /idTUdmin="U198" /TUdmin=176 /isTUend="FALSE" CDS complement(295584..296285) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [NatK]" /protein_id="NP_388156.1" /db_xref="EnsemblGenomes-Gn:BSU02740" /db_xref="EnsemblGenomes-Tr:CAB12068" /db_xref="GOA:P70955" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11998" /db_xref="UniProtKB/Swiss-Prot:P70955" /translation="MVKVGLVDDYRVDLEKLEAIVSRMQDVEIVFSTDSAKEAYRRVK NGDIDLLLADIEMPHMSGYELADLIKSHSLDVDVIFVTGHGGYAVHAFDLNVHDYIMK PYYADRLAASFDRYLKKKTETSLNGRILIKQKSEMHVLQKKDIIFAERTGRSTTIVTT AEEVQTYQTLNDIKGDLPEKDFLRSHRSFIINIHYIKHFSAYTKHSFTVSFEGTSKKA MITKQQLDYFQNYYF*" gene complement(295584..296285) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" promotor_-10 complement(296309..296328) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(296315) /Source="Nicolas_upshifts" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" promotor_-35 complement(296344..296347) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 296365..296368 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 296384..296403 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 296394 /Source="Nicolas_upshifts" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" CDS 296429..297169 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10356997, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388157.1" /db_xref="EnsemblGenomes-Gn:BSU02750" /db_xref="EnsemblGenomes-Tr:CAB12069" /db_xref="GOA:P46903" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11338" /db_xref="UniProtKB/Swiss-Prot:P46903" /translation="MITLTDCSRRFQDKKKVVKAVRDVSLTIEKGEVVGILGENGAGK TTMLRMIASLLEPSQGVITVDGFDTVKQPAEVKQRIGVLFGGETGLYDRMTAKENLQY FGRLYGLNRHEIKARIEDLSKRFGMRDYMNRRVGGFSKGMRQKVAIARALIHDPDIIL FDEPTTGLDITSSNIFREFIQQLKREQKTILFSSHIMEEVQALCDSVIMIHSGEVIYR GALESLYESERSEDLNYIFMSKLVRGIS*" gene 296429..297169 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" CDS 297170..298330 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10356997, 15849754, 16850406, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 15849754, 16850406, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (permease)" /protein_id="NP_388158.1" /db_xref="EnsemblGenomes-Gn:BSU02760" /db_xref="EnsemblGenomes-Tr:CAB12070" /db_xref="GOA:P46904" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11339" /db_xref="UniProtKB/Swiss-Prot:P46904" /translation="MLSHIYKKEMIDALRDRKTILLTILVPMIMMLGLVFFYESMLSD KGEQYTLAVGHSLPPALESKLNEIDEISVKTFAKPEEAVDEGKADAYLNVPKEFDSYV NSMTPFKVDVYGNSIDQGSSNAMQLVQSALDQYKNEIVQQRLTNKHIDQSVIQPFTIQ QKEADEEKGTSAIMLSAILPMLILTSIVSGAMPIALDIMAGEKDRKSIEALLLTPVSR NKVLVGKWLAVSTFGVASGVFALVFLILSTVLFTENLKTAFQLGDHMWSVIGASALII VLSALLISAMELFISIMSSSVKEAQSYMSLVVFLPVFPMFFIFSKAPNQFDLSYFLIP FLNLHALFKQLLFGMVDPATILSTSGTIAVLIAIFFLLARACFLKDKWVLPK*" gene 297170..298330 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" promotor_-35 298381..298389 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 298401..298419 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 298401 /Source="Nicolas_upshifts" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" CDS 298466..299398 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" /EC_number="1.-.-.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322186, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ion channel associated aldo-keto reductase" /protein_id="NP_388159.1" /db_xref="EnsemblGenomes-Gn:BSU02770" /db_xref="EnsemblGenomes-Tr:CAB12071" /db_xref="GOA:P46905" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11340" /db_xref="UniProtKB/Swiss-Prot:P46905" /translation="MDQTRTLGKTKLKVKRIGFGANAVGGHNLFPNLNDETGKDLVRT ALDGGVNFIDTAFIYGLGRSEELIGEVVQERGVRNELIIATKGAHKEVDGSIELDNSR EFLRSEVEKSLKRLKTDYIDLYYVHFPDGKTPLAEVAGTLKELKDEGKIKAIGASNLD YQQLQDFNADGYLEVFQAEYSLIQRDAEKELLPYCEKQGISFIPYFPLASGLLTGKFT QDTVFDDFRKDKPQFQGETFIHNLKKVDKLKAVAEEKQADTAHVALAWLLTRPAIDAI IPGAKRPEQLQDNLKTLNIELTEDEVNFISDIFK*" gene 298466..299398 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" CDS complement(299438..300502) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 22496484; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in swarming behaviour" /protein_id="NP_388160.1" /db_xref="EnsemblGenomes-Gn:BSU02780" /db_xref="EnsemblGenomes-Tr:CAB12072" /db_xref="GOA:O34538" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="InterPro:IPR031343" /db_xref="PDB:4R4G" /db_xref="SubtiList:BG12757" /db_xref="UniProtKB/Swiss-Prot:O34538" /translation="MFQKKTYAVFLILLLMMFTAACSGSKTSAEKKESETEKSSDIAQ VKIKDVSYTLPSKYDKSTSDDQLVLKVNVAVKNTGKDPLNVDSMDFTLYQGDTKMSDT DPEDYSEKLQGSTINADKSVEGNLFFVVDKGKQYELNYTPESYGDKKPKSVTFKIDGK DKKILATADKLQDSAKALSAYVDVLLFGKDNADFEKITGANKNEIVNDFNESAKDGYL SASGLSSTYADSKALDNIVNGIKEGLSKNSSIQAKTTSISKDEAIVEATVKPVDASSL SDRIEDKVKDYYSKNSSASYEEAVKYALQVYPEEFKKLGPASSEKTVEVKMKKNDIDQ WQLDMDDYRAAELVEAFIKE*" gene complement(299438..300502) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" downshifts complement(299439) /Source="Nicolas_upshifts" /id="D114" /incds=0 /nref=198 /ntot=222 /MaxReadThrough="0.57029" /MaxDrop="8.85093" /score="27.0612397" /energy="-13.7" /TU="NA" /idTUdmin="U201" /TUdmin=0 /isTUend="TRUE" S_feature complement(300503..300693) /Source="Nicolas_S_feature" /locus_tag="new_300503_300693_c" /HighExp="S5, S4, MG 45, MG 15, MG-0.2, MG 25, MG-0.1, MG 10, S3, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S101" CDS complement(300525..300656) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513941.1" /translation="MTKEGGVSRKSGENREKRTDFFGYMMLIHSKRSISQRQKTPLS* " gene complement(300525..300656) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" promotor_-10 complement(300678..300697) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(300698) /Source="Nicolas_upshifts" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" promotor_-35 complement(300712..300719) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 300830..302248 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388161.1" /db_xref="EnsemblGenomes-Gn:BSU02790" /db_xref="EnsemblGenomes-Tr:CAB12073" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12758" /db_xref="UniProtKB/Swiss-Prot:O34621" /translation="MKGAAFVKKEGLKQKALEIGRVPTHLKLEIEDYGGDDKRAHFCW ADPQDENTGIIVELGPDGELESLSRDIEPESGERLSEEKLEDIMRQFVETHHPGALSA FVREENDRAYGDKVRFSYVQMEAGLPLPMSGFMADVSLSGEIVYFRYYGEAGSIIKPK RVADVEEALAFIKKDVEFDLLFEVLHRSVYKNGDDQPHLVYEPEGRAITVPADLVQEE QAVDDDDDYREPESFPLPLFEGIREKADPDSMIGIENGFVKEREADLGDGRIGIVWRN PDDPVYQPADKSMDSWFKGRTHQVLKTIYNKETGKLEGVMSFMEKKGPLTVTLAECEK IALRFLFALFPNADQYFRIRYDEKDEEENAVAGFTFEAHCHGVPLRFGQIRICVSRQT GYITVYMGPDIDPNKLATIDPVPAISVEQAKSIFWQHFKVELGWEREYGDDEEHSYRL VYKPVYPHFIDAHTGEPVFSIW*" gene 300830..302248 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" promotor_-10 complement(302291..302309) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(302299) /Source="Nicolas_upshifts" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(302323..302330) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 302355..302434 /Source="Nicolas_S_feature" /locus_tag="new_302355_302434" /HighExp="ferm, M40t45, M0t45, Lbstat, S0, nit, LBGtran, Lbtran, G135, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S102" upshifts 302355 /Source="Nicolas_upshifts" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" promotor_-35 302357..302363 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-35" promotor_-10 302378..302395 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-10" CDS 302435..303796 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388162.1" /db_xref="EnsemblGenomes-Gn:BSU02800" /db_xref="EnsemblGenomes-Tr:CAB12074" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12759" /db_xref="UniProtKB/Swiss-Prot:O34772" /translation="MVNKQLKKKAQEIGNVPTHYELEIEDYDQKQKKYGQAYFIWKDP KDPEKHITVELRNDGALLTFSTTVHSETDKKLPDAELKLTALQFAAANHPGTFMNFHF QGKEERGQHIRFVYTKMELGLPIPNSGFLIDMTRSGQIVHFLYYGEGHKAEVPTEFVA KEKVVSHYLNTMSFELMYDVIDGEQEPRLVYEPILPGYSYPADVDEIVPDQHIADERI ENTAPLPPLQNKEEVDIFALLGFTSDMQKVSERDFGEQIGSTWRRGAAPERKDLSIGS YFETRNKNTIKMKTDKRTGKLKAALSFMDWRNNLQCSTEECQEIALQFLYALYPRAAE FFRVNPVRIDERGRVRNHFSVWYKGVPLRFGAARIIVNPETGLIDAFMAPDIEPEQLE AINHRPDVSAEEAKEAFLAAFDVKLEWQPDFTAGSDQHCKLVYKPVYPSYIDAHIRKK KRL*" gene 302435..303796 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" S_feature 303797..304377 /Source="Nicolas_S_feature" /locus_tag="new_303797_304377" /HighExp="ferm, M0t45, G135, G180, H2O2, M40t45, G150, Paraq, S0, nit" /AntisenseName="cwlK" /AntisenseCor="0.27553388443794402" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S103" CDS complement(303804..304307) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17588176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17588176; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="murein L,D:-endopeptidase" /protein_id="NP_388163.1" /db_xref="EnsemblGenomes-Gn:BSU02810" /db_xref="EnsemblGenomes-Tr:CAB12075" /db_xref="GOA:O34360" /db_xref="InterPro:IPR009045" /db_xref="SubtiList:BG12760" /db_xref="UniProtKB/Swiss-Prot:O34360" /translation="MNLPAKTFVILCILFLLDLCFSYIRHEWHSQNALQDMPVPSDLH PIVKQNADALKAAAANKGIDVVITEGFRSFKEQDELYKQGRTKKGNIVTYARGGESYH NYGLAIDFALQKKDGSIIWDMEYDGNQNGKSDWLEVVEIAKTLGFEWGGDWKRFKDYP HLEMIPN*" gene complement(303804..304307) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" S_feature complement(304308..304389) /Source="Nicolas_S_feature" /locus_tag="new_304308_304389_c" /HighExp="Cold, T0.30H, LBGstat, C30, T-0.40H, T1.0H, T1.30H, H2O2, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S104" upshifts 304379 /Source="Nicolas_upshifts" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" promotor_-10 complement(304381..304400) /Source="Nicolas_upshift_promotors" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 304382..304401 /Source="Nicolas_upshift_promotors" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(304390) /Source="Nicolas_upshifts" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" promotor_-35 complement(304413) /Source="Nicolas_upshift_promotors" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 304430..305551 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16816200; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388164.1" /db_xref="EnsemblGenomes-Gn:BSU02820" /db_xref="EnsemblGenomes-Tr:CAB12076" /db_xref="GOA:O34327" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:4GYO" /db_xref="SubtiList:BG12663" /db_xref="UniProtKB/Swiss-Prot:O34327" /translation="MRAKIPSEEVAVKLNEWYKLIRAFEADQAEALKQEIEYDLEDME ENQDLLLYFSLMEFRHRIMLDKLMPVKDSDTKPPFSDMLNEIESNQQKLTGLLEYYFY YFRGMYEFKQKNFILAIDHYKHAEEKLEYVEDEIEKAEFLFKVAEVYYHIKQTYFSMN YASQALDIYTKYELYGRRRVQCEFIIAGNLTDVYHHEKALTHLCSALEHARQLEEAYM IAAAYYNVGHCKYSLGDYKEAEGYFKTAAAIFEEHNFQQAVQAVFSLTHIYCKEGKYD KAVEAYDRGIKSAAEWEDDMYLTKFRLIHELYLGSGDLNVLTECFDLLESRQLLADAE DLLHDTAERFNQLEHYESAAFFYRRLMNIKKKLAEQRFQ*" gene 304430..305551 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" downshifts 305545 /Source="Nicolas_upshifts" /id="D115" /incds=0 /nref=88 /ntot=228 /MaxReadThrough="3.8438" /MaxDrop="5.06867" /score="32.2653577" /energy="-13.2" /TU="U204" /idTUdmin="U204" /TUdmin="-66" /isTUend="FALSE" promotor_-35 305592..305598 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 305613..305631 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 305616 /Source="Nicolas_upshifts" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" CDS 305658..306434 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388165.1" /db_xref="EnsemblGenomes-Gn:BSU02830" /db_xref="EnsemblGenomes-Tr:CAB12077" /db_xref="GOA:P80869" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12761" /db_xref="UniProtKB/Swiss-Prot:P80869" /translation="MYKDLTGKTAIVTGSSKGIGKAIAERFGKEKMNVVVNYHSDPSG ADETLEIIKQNGGKAVSVEADVSKEEGIQALLDTALEHFGTLDVMVNNSGFNGVEAMP HEMSLEDWQRVIDVNVTGTFLGAKAALNHMMKNNIKGNVLNISSVHQQIPRPVNVQYS TSKGGIKMMTETLALNYADKGIRVNAIAPGTIATESNVDTKKEESRQKQLKKIPMKAF GKPEEVAAAAAWLVSEEASYVTGATLFVDGGMTLYPSQLE*" gene 305658..306434 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" downshifts complement(305665) /Source="Nicolas_upshifts" /id="D116" /incds=0 /nref=10 /ntot=23 /MaxReadThrough="0.31912" /MaxDrop="4.8095" /score="0.506500496" /energy="-5.8" /TU="NA" /idTUdmin="U205" /TUdmin="-1914" /isTUend="FALSE" CDS 306459..308144 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544224; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oligo-carbohydrate hydrolase" /protein_id="NP_388166.1" /db_xref="EnsemblGenomes-Gn:BSU02840" /db_xref="EnsemblGenomes-Tr:CAB12078" /db_xref="GOA:O34364" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12762" /db_xref="UniProtKB/Swiss-Prot:O34364" /translation="MKTDWWKDAVVYQIYPRSFQDSNGDGIGDLRGIISRLDYIKELG ADVIWICPIYPSPNVDYGYDVTNHKAIMDSYGTMDDFHELLDQVHQRGLKLVMDFVLN HTSVEHPWFKEAELDKNSKYRSYYYWRPGTKNGPPTDWLSNYGCPVWQYEEHTGEYYL HMNAVKQADLNWENPEVRQAVYDMMKFWLDKGVDGLRIDQLHLISKKEYLPSYEDYIN QQAEPKPFQPNGERIHDYLKEITDEVFSHYDVMSVGEVGSVTPEEGLKYTGTDKHELN MIFHFQHMELDQQPGKEHWDLKPLELSDLKSVLTKWQKKLEHQGWNTLFWCNHDQPRI VSRFGDDGEYRKASAKMLAAVIYFMKGTPYIYQGEEIGMTNAPFTRIEDYKDIQTINM YHKRVFEKGYDPNDVMRSILAKSRDHARTPMQWNSGKNAGFTDGTPWLKVNPNFTAIN VEEAQGDPDSVLNYYKKLISLRKQYADLMKGSFDLLLPDDPQLFVYMRENSKQQLLSV NNFSKEQAVFQWPKNCGKAQASLLLSNYNNDDLDDEMVFRPYESRVYLLDKTN*" gene 306459..308144 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" promotor_no_box 307399..307499 /Source="Nicolas_upshift_promotors" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 307459 /Source="Nicolas_upshifts" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 307525 /Source="Nicolas_upshifts" /id="D117" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.77365" /MaxDrop="2.18547" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=1914 /isTUend="FALSE" downshifts 308141 /Source="Nicolas_upshifts" /id="D118" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="5.8252" /MaxDrop="5.18702" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=2530 /isTUend="FALSE" promotor_-35 308235..308242 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 308258..308277 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 308264 /Source="Nicolas_upshifts" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" CDS 308332..309291 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9379902, 12426338, 14730579, 21813502; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="Zn(II)-binding lipoprotein" /protein_id="NP_388167.1" /db_xref="EnsemblGenomes-Gn:BSU02850" /db_xref="EnsemblGenomes-Tr:CAB12079" /db_xref="GOA:O34966" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="PDB:2O1E" /db_xref="SubtiList:BG12763" /db_xref="UniProtKB/Swiss-Prot:O34966" /translation="MFKKWSGLFVIAACFLLVAACGNSSTKGSADSKGDKLHVVTTFY PMYEFTKQIVKDKGDVDLLIPSSVEPHDWEPTPKDIANIQDADLFVYNSEYMETWVPS AEKSMGQGHAVFVNASKGIDLMEGSEEEHEEHDHGEHEHSHAMDPHVWLSPVLAQKEV KNITAQIVKQDPDNKEYYEKNSKEYIAKLQDLDKLYRTTAKKAEKKEFITQHTAFGYL AKEYGLKQVPIAGLSPDQEPSAASLAKLKTYAKEHNVKVIYFEEIASSKVADTLASEI GAKTEVLNTLEGLSKEEQDKGLGYIDIMKQNLDALKDSLLVKS*" gene 308332..309291 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" promotor_-35 308887..308893 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 308907..308926 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 308911 /Source="Nicolas_upshifts" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" downshifts 309263 /Source="Nicolas_upshifts" /id="D119" /incds=0 /nref=140 /ntot=250 /MaxReadThrough="6.07181" /MaxDrop="5.15011" /score="8.99106569" /energy="-15.9" /TU="U206,U208,U209" /idTUdmin="U206" /TUdmin="-1562" /isTUend="FALSE" CDS 309347..310042 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Zn(II) transporter (ATP-binding protein)" /protein_id="NP_388168.1" /db_xref="EnsemblGenomes-Gn:BSU02860" /db_xref="EnsemblGenomes-Tr:CAB12080" /db_xref="GOA:O34946" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12764" /db_xref="UniProtKB/Swiss-Prot:O34946" /translation="MNLVSLKDIVFGYSHTPVLDKVSLDIESGEFVGITGPNGASKST LIKVMLGMLKPWEGTVTISKRNTEGKRLTIGYVPQQISSFNAGFPSTVLELVQSGRYT KGKWFKRLNEEDHLEVEKALKMVEMWDLRHRKIGDLSGGQKQKICIARMLASNPDLLM LDEPTTAVDYDSRKGFYEFMHHLVKNHNRTVVMVTHEQNEVQQFLDKVIRLERGEKGG WKCLTWNSCDELF*" gene 309347..310042 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" CDS 310000..310842 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity Zn(II) ABC transporter (permease)" /protein_id="NP_388169.1" /db_xref="EnsemblGenomes-Gn:BSU02870" /db_xref="EnsemblGenomes-Tr:CAB12081" /db_xref="GOA:O34610" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12765" /db_xref="UniProtKB/Swiss-Prot:O34610" /translation="MEMFDLEFMRRAFLAGGMIAVMAPILGVYLVLRRQALMADTLSH ISLSGVAIGFFLSTNITAASIVVVTIGAIGIEYMRRAYRTYSEVSIAILMAAGLSFAM FLISLSKGTANMSIDQYLFGSLVTVNQQQVYIISIITLLILLYFIVLRRPLYLLTFDE ATAKTSGINTNVLSLSFSIVTGLAISVIIPIIGVLLVSALLVLPAAFAIRIAKGFNMV FITAILISLFSVFTGLTSSYQLGTPPGPSITLLLIVLLLIGFAVQGVWTFIKKEAQRK KRSR*" gene 310000..310842 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" downshifts 310829 /Source="Nicolas_upshifts" /id="D120" /incds=0 /nref=168 /ntot=266 /MaxReadThrough="2.4865" /MaxDrop="6.44929" /score="27.8218406" /energy="-13.6" /TU="NA" /idTUdmin="U206" /TUdmin=4 /isTUend="TRUE" CDS complement(310880..311875) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16428414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative luciferase-like monooxygenase" /protein_id="NP_388170.2" /db_xref="EnsemblGenomes-Gn:BSU02880" /db_xref="EnsemblGenomes-Tr:CAB12082" /db_xref="GOA:O34504" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12766" /db_xref="UniProtKB/Swiss-Prot:O34504" /translation="MIHLSILDQAPVSKGESPVTTLQHSVELAQLSEQWGYKRYWFAE HHSTKGLASTAPEIMIARIAAQTNTIRVGSGGVLLPQYSPFKVAETFRQLEALYPNRI DLGVGRSPGGTTKTRLALTDGVKKSLTEFNRQLQDVSYFLTDSLPPDHPYAGIKAAPL IGTAPELWVLGLGENSARRAAHQGIGYVFGHFINPERGENAFRIYRESFRPSAHFSNP SALFTIFVICAKTDEEAEELALSQDLWLLRVGKGLDSRVPSIEEAKAHPYTASDKKLI EENRKRMVIGSPTTVKQQLLDLTGCYETNEIMVLCNVFDFEAKKESYERLAELFL*" gene complement(310880..311875) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" promotor_-35 311831..311838 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-35" promotor_-10 311853..311872 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-10" S_feature 311859..312061 /Source="Nicolas_S_feature" /locus_tag="new_311859_312061" /HighExp="Diami, Etha, dia5, Salt, H2O2, dia15, Paraq, T-0.40H, T0.30H, G135" /AntisenseName="yceB" /AntisenseCor="0.84300534435872998" /AntisenseRegPval="-73.099999999999994" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S105" upshifts 311859 /Source="Nicolas_upshifts" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" promotor_-10 complement(311907..311926) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(311915) /Source="Nicolas_upshifts" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" promotor_-35 complement(311941..311948) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 312045..312054 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 312063..312158 /Source="Nicolas_S_feature" /locus_tag="new_312063_312158" /HighExp="T0.0H, T-0.40H, T-1.10H, T0.30H, Salt, T1.0H, Etha, T-1.40H, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S106" upshifts 312063 /Source="Nicolas_upshifts" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" promotor_-10 312067..312082 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 312159..312758 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388171.1" /db_xref="EnsemblGenomes-Gn:BSU02890" /db_xref="EnsemblGenomes-Tr:CAB12083" /db_xref="GOA:P81100" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12767" /db_xref="UniProtKB/Swiss-Prot:P81100" /translation="MAISLEKGQRIDLTKGKAGLSKLMVGLGWDPVSSGGGFFSKLLG GGGPNIDCDASVLMLENGKFTDKKNLIYFGNLKSRCGGVQHTGDNLTGDGAGDDEQIM IDLDKVPGNIDKLVFVVNIYDCVRRKQDFGMIQNAFIRVVDQSNHEEMLKYNLRDNYA GRTSLITAEIYRSGSEWKFAAVGEGTNDTRLEDIISRYV*" gene 312159..312758 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" CDS 312780..313361 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388172.1" /db_xref="EnsemblGenomes-Gn:BSU02900" /db_xref="EnsemblGenomes-Tr:CAB12084" /db_xref="GOA:P80875" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12768" /db_xref="UniProtKB/Swiss-Prot:P80875" /translation="MTISLAKGQKVDLTKTNPGLSKVVVGLGWDTNKYDGGHDFDLDS SVFLLDAAGKCASPNDFIFYNQLEGGNGSVVHSGDNLTGAGEGDDENVKVNLSAVPAN IDKISFVITIHDAEARSQNFGQVSNAFVRIVNEETNEELIRYDLAEDFSIETAIIAGE LYRHNGEWKFSAIGSGYQGGLARIATDYGLQVG*" gene 312780..313361 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" CDS 313396..313974 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388173.1" /db_xref="EnsemblGenomes-Gn:BSU02910" /db_xref="EnsemblGenomes-Tr:CAB12085" /db_xref="GOA:O34384" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12769" /db_xref="UniProtKB/Swiss-Prot:O34384" /translation="MAIQLSKGQRIDLTKTNPGLTKAVIGLGWDTNKYSGGHDFDLDA SAFLVDAHDNCVNDLDFVFYNNLEHPSGGVIHTGDNRTGEGDGDDEQIIVDFSKIPAH IEKIGITVTIHDAEARSQNFGQVSNAFVRVVDEETQNELLRFDLGEDFSIETAVVVCE LYRHGGEWKFNAIGSGFSGGLAALCRNYGLQV*" gene 313396..313974 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" CDS 314025..314798 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 24366250; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative stress adaptation transporter (tellurite resistance)" /protein_id="NP_388174.1" /db_xref="EnsemblGenomes-Gn:BSU02920" /db_xref="EnsemblGenomes-Tr:CAB12086" /db_xref="GOA:O34447" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="SubtiList:BG12770" /db_xref="UniProtKB/Swiss-Prot:O34447" /translation="MDFLHHILSTYASFFDWKMWGEVLTDPVSWGLIGSLVVLEGLLS ADNALVLAVMVKHLPEKQRKKALTYGLFGAYIFRFIFIGLGMLLIKFWWIKVLGALYL AWLVIKHFWIGEKEEEADGMKKNSWMVRTFGIFWATVISVELMDLAFSVDSILAAFAV SEKVWVLLIGGMLGILMMRTVAKVFLVLIDKIPELENTAFVLIGIIALKMAGSAFHYE MPHSVFFIIIIAAFAVTLIIHYINKQKQVREQTAASKEE*" gene 314025..314798 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" downshifts 314785 /Source="Nicolas_upshifts" /id="D121" /incds=0 /nref=46 /ntot=239 /MaxReadThrough="6.82513" /MaxDrop="4.0674" /score="4.0495978" /energy="-8.2" /TU="U212" /idTUdmin="U210" /TUdmin=2728 /isTUend="FALSE" CDS 314883..316496 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxic compound adaptation protein (tellurite resistance)" /protein_id="NP_388175.1" /db_xref="EnsemblGenomes-Gn:BSU02930" /db_xref="EnsemblGenomes-Tr:CAB12087" /db_xref="InterPro:IPR025647" /db_xref="SubtiList:BG12771" /db_xref="UniProtKB/Swiss-Prot:O34809" /translation="MRQEELTIHKALPADGDWKSLLFQPLPERDHYETAQGLSFSRLA GQILGTPIDETDYYNELYELSVNDRITILSETLDKTIEPETFQKLQHIHSINQKEKGL SVSRFVAFLDGEKLIAKHSNPLMHRHLRKALMTLLHTFADSHEKGLNHPDFRRVLLDV SKFSLNHLNPWLEKTDIEREMPKVVWYGDATKSQLYFLYYLMLVGCDVLLFHPAGTDQ LALVDPKQELGFTEKLPDVSELQPFPKEKPDRKSTVAYRSTKEIEHVLNHEESMLYKP WQFRDHTPVSVTLKTTYDELFLITKERAFIRPNFKADKHSIEIPNVFAKIMGVSKDNK EYWNRLHTLADYQETEMVRSFPFTEEIKSNYQFHYSHALDQEGNIDPDKLMASNVWQY KQLPAGVQTAIAKTISRMCRYPRLKALHQEQVKDVQIYLFKQTTNLPANLLKLIQMFD YAQTVPKLVLYHTEMSGGLTRSDAAALLFLNEIGIDIIIYNPPGHQDIEQFIEEDQYD IHWLDDMVFQQDYKEPSLVKRLFRTITQK*" gene 314883..316496 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" CDS 316512..317603 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative reactive oxygen species resistance protein" /protein_id="NP_388176.1" /db_xref="EnsemblGenomes-Gn:BSU02940" /db_xref="EnsemblGenomes-Tr:CAB12088" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG12772" /db_xref="UniProtKB/Swiss-Prot:O34833" /translation="MTTENQNPLVLDKNEEISQQKADDIRLQLRQEPEVKRLAQQIDV KNQMELLEYGKEPAVEISKFSDRILGMMKTTSVTDSGTMLTQLGKIMDRFDKNDFDEP KGLMAKIFKRGGSMIEKIFKKYQTLGGEIEKIHVEISKYKDEMTKTNYTLDEMYENNI KYYMELEKYVVAGQMKLEEMQSILPSYEEKAASGNQLAQMQLDTLRNGIQALEERVYD LDMARMVALQTAPQIRLLQRGNAKLIGKINSAFIITIPIFKNGIIQAVTVKRQKLVAD SMSELDRRTNEMLKRNAENISSQSVEIARMAGRPSIDIETIESSWNTIVSGMQETKQI EEENKRLREDGARRIAQLQDNIKKAALQQ*" gene 316512..317603 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" downshifts 317577 /Source="Nicolas_upshifts" /id="D122" /incds=0 /nref=85 /ntot=228 /MaxReadThrough="4.46836" /MaxDrop="4.05585" /score="-6.59172775" /energy="-17.5" /TU="U212" /idTUdmin="U212" /TUdmin="-1322" /isTUend="FALSE" promotor_-35 317657..317664 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 317679..317698 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 317687 /Source="Nicolas_upshifts" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" CDS 317725..318927 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18276644, 21953179" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18276644, 21953179; Product type t: transporter" /codon_start=1 /transl_table=11 /product="niacin permease" /protein_id="NP_388177.1" /db_xref="EnsemblGenomes-Gn:BSU02950" /db_xref="EnsemblGenomes-Tr:CAB12089" /db_xref="GOA:O34691" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12773" /db_xref="UniProtKB/Swiss-Prot:O34691" /translation="MGKQQPISQRKLLGVAGLGWLFDAMDVGILSFIIAALHVEWNLS PEEMKWIGSVNSIGMAAGAFLFGLLADRIGRKKVFIITLLCFSIGSGISAFVTSLSAF LILRFVIGMGLGGELPVASTLVSEAVVPEKRGRVIVLLESFWAVGWLAAALISYFVIP SFGWQAALLLTALTAFYALYLRTSLPDSPKYESLSAKKRSMWENVKSVWARQYIRPTV MLSIVWFCVVFSYYGMFLWLPSVMLLKGFSMIQSFEYVLLMTLAQLPGYFSAAWLIEK AGRKWILVVYLIGTAGSAYFFGTADSLSLLLTAGVLLSFFNLGAWGVLYAYTPEQYPT AIRATGSGTTAAFGRIGGIFGPLLVGTLAARHISFSVIFSIFCIAILLAVACILIMGK ETKQTELE*" gene 317725..318927 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" downshifts 318907 /Source="Nicolas_upshifts" /id="D123" /incds=0 /nref=8 /ntot=184 /MaxReadThrough="4.1968" /MaxDrop="3.48367" /score="13.0427769" /energy="-10.6" /TU="U213" /idTUdmin="U212" /TUdmin=8 /isTUend="TRUE" CDS complement(319180..320352) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carbohydrate transporter (possibly exporter)" /protein_id="NP_388178.1" /db_xref="EnsemblGenomes-Gn:BSU02960" /db_xref="EnsemblGenomes-Tr:CAB12090" /db_xref="GOA:O34724" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12774" /db_xref="UniProtKB/Swiss-Prot:O34724" /translation="MNRIWLFFSVMFVIGTDTFLLSPLLPLLQDQFHVSTDLSGWMVS AYALGYALFAFIAGPISDRLNRKTVMLWGLAGFIVSTFLCGIAPSFAAMCLFRFAAGV SAAFVTPQIWASIPVIVQPSQIIKGMGIATAGLAASQMLGLPIGGFLASFTWHTPFFV LSACSLILLLILAAVMPGIRPSEPLARPSIVNPYRELFSLPKTSVILLAYFLFQTGNF ASFSFLGTWLSADYHLTVSQIGAAMLVLGLGNMLGSLIGSRVSEKLGMFKTLISGMLL MGALYFALPFFPNLFLVEAGFFLTFFTAGIIFPLMMGVFQSIAPNARGTIASLSNAAM YAGTTVGTSIAGFLYQSTQHFGAVTGFTAILFILSMTLYQTISKTGKRQSTARAQL*" gene complement(319180..320352) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" downshifts complement(319195) /Source="Nicolas_upshifts" /id="D124" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="2.6211" /MaxDrop="2.7452" /score="9.21991741" /energy="-12.6" /TU="NA" /idTUdmin="U214" /TUdmin=0 /isTUend="TRUE" CDS complement(320421..320723) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (ArsR family)" /protein_id="NP_388179.1" /db_xref="EnsemblGenomes-Gn:BSU02970" /db_xref="EnsemblGenomes-Tr:CAB12091" /db_xref="GOA:O34464" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12775" /db_xref="UniProtKB/Swiss-Prot:O34464" /translation="MYYSFMTMKQSDDQIRAQIFKALSDESRLAIIRTLYVSGKELSC GEVGEKCNIVKTTASYHFKTLREAGLTATRKDSRTKYVSLREDTFQTYLPGFLETL*" gene complement(320421..320723) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" downshifts complement(320449) /Source="Nicolas_upshifts" /id="D125" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="5.67096" /MaxDrop="6.89889" /score="2.01231069" /energy="-4.8" /TU="U214" /idTUdmin="U214" /TUdmin="-1254" /isTUend="FALSE" promotor_-10 complement(320706..320725) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(320725) /Source="Nicolas_upshifts" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" promotor_-35 complement(320739..320745) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 320972..320991 /Source="Nicolas_upshift_promotors" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 320972 /Source="Nicolas_upshifts" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" CDS 321013..322269 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(ATP-binding protein)" /protein_id="NP_388180.2" /db_xref="EnsemblGenomes-Gn:BSU02980" /db_xref="EnsemblGenomes-Tr:CAB12092" /db_xref="GOA:P46920" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11370" /db_xref="UniProtKB/Swiss-Prot:P46920" /translation="MSVDEKPIKIKVEKVSKIFGKQTKKAVQMLANGKTKKEILKATG STVGVNQADFEVYDGEIFVIMGLSGSGKSTLVRMLNRLIEPTAGNIYIDGDMITNMSK DQLREVRRKKISMVFQKFALFPHRTILENTEYGLELQGVDKQERQQKALESLKLVGLE GFEHQYPDQLSGGMQQRVGLARALTNDPDILLMDEAFSALDPLIRKDMQDELLDLHDN VGKTIIFITHDLDEALRIGDRIVLMKDGNIVQIGTPEEILMNPSNEYVEKFVEDVDLS KVLTAGHIMKRAETVRIDKGPRVALTLMKNLGISSIYAVDKQKKLLGVIYASDAKKAA ESDLSLQDILNTEFTTVPENTYLTEIFDVVSDANIPIAVVDEKQRMKGIVVRGALIGA LAGNNEYINAEGTNEQTQDPSAQEVK*" gene 321013..322269 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" downshifts complement(321021) /Source="Nicolas_upshifts" /id="D126" /incds=0 /nref=108 /ntot=175 /MaxReadThrough="2.83797" /MaxDrop="5.18503" /score="2.01231069" /energy="-4.8" /TU="NA" /idTUdmin="U214" /TUdmin="-1826" /isTUend="FALSE" CDS 322271..323119 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752321, 15849754, 16225868, 16645306, 16850406, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752321, 15849754, 16225868, 16645306, 16850406, 25012968; Product type t : transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(permease)" /protein_id="NP_388181.1" /db_xref="EnsemblGenomes-Gn:BSU02990" /db_xref="EnsemblGenomes-Tr:CAB12093" /db_xref="GOA:P46921" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11371" /db_xref="UniProtKB/Swiss-Prot:P46921" /translation="MDRLPRIPLADIIDRFVDWITMTFGGFFDGIANGLAAFVNGIVT GLGFIPSILLTIIFAALAWWISTRGIALFTLIGFLLIDYLGYWDPMLQTLALVLTSVI ISIVVGVPIGIWASQKETVRRIVTPILDLMQTMPAFVYLLPAIFFFNIGVVPGVVASV IFAMPPTIRMTVLGIKQVPADLIEATEAFGSTTAQRLFKVQLPLATKTILAGINQSIM LALSMVVIAAMVGAPGLGSEVYSAVTQLKTGVGVEAGIAIVIVAITLDRITQNIKVKK KSRGNA*" gene 322271..323119 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" CDS 323119..324000 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporterABC transporter (glycine betaine-binding lipoprotein)" /protein_id="NP_388182.1" /db_xref="EnsemblGenomes-Gn:BSU03000" /db_xref="EnsemblGenomes-Tr:CAB12094" /db_xref="GOA:P46922" /db_xref="InterPro:IPR007210" /db_xref="PDB:2B4L" /db_xref="PDB:2B4M" /db_xref="PDB:3CHG" /db_xref="SubtiList:BG11372" /db_xref="UniProtKB/Swiss-Prot:P46922" /translation="MLKKIIGIGVSAMLALSLAACGSENDENASAAEQVNKTIIGIDP GSGIMSLTDKAMKDYDLNDWTLISASSAAMTATLKKSYDRKKPIIITGWTPHWMFSRY KLKYLDDPKQSYGSAEEIHTITRKGFSKEQPNAAKLLSQFKWTQDEMGEIMIKVEEGE KPAKVAAEYVNKHKDQIAEWTKGVQKVKGDKINLAYVAWDSEIASTNVIGKVLEDLGY EVTLTQVEAGPMWTAIATGSADASLSAWLPNTHKAYAAKYKGKYDDIGTSMTGVKMGL VVPQYMKNVNSIEDLKK*" gene 323119..324000 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" downshifts 323981 /Source="Nicolas_upshifts" /id="D127" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="0.74967" /MaxDrop="8.21394" /score="33.6263027" /energy="-12.2" /TU="NA" /idTUdmin="U215" /TUdmin=0 /isTUend="TRUE" downshifts complement(324013) /Source="Nicolas_upshifts" /id="D128" /incds=0 /nref=2 /ntot=62 /MaxReadThrough="4.29566" /MaxDrop="3.9514" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-220" /isTUend="FALSE" CDS complement(324038..325189) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8768514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388183.2" /db_xref="EnsemblGenomes-Gn:BSU03010" /db_xref="EnsemblGenomes-Tr:CAB12095" /db_xref="GOA:P54983" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11789" /db_xref="UniProtKB/Swiss-Prot:P54983" /translation="MQKLSEEMKQTIMDIFEHLHANPEVSWKEYETTSFLKQKLEDLG CRTRTFSDCTGVVGEIGSGSPVVAVRADIDALWQEVNGTFRANHSCGHDSHMTMALGT LMLLKKQPELPKGTIRFIFQPAEEKGGGALKMIEEGVLDDIDYLYGVHVRPIQETQNG RCAPSILHGSSQHIEGTIIGEEAHGARPHLGKNSIEIAAFLVHKLGLIHIDPQIPHTV KMTKLQAGGESSNIIPGKASFSLDLRAQTNEAMEALIAETERACEAAAAAFGAKIELH KEHSLPAATQNKEAEAIMAEAITEIIGAERLDDPLVTTGGEDFHFYAVKVPNLKTTML GLGCGLQPGLHHPHMTFDRNAMFTGIHILANAVLKTFQKAESLAAANAS*" gene complement(324038..325189) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" downshifts complement(324057) /Source="Nicolas_upshifts" /id="D129" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="4.33606" /MaxDrop="3.5225" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-264" /isTUend="FALSE" S_feature complement(325190..325277) /Source="Nicolas_S_feature" /locus_tag="new_325190_325277_c" /HighExp="Etha, T1.30H, M9-stat, T2.30H, S1, T3.30H, T5.0H, T4.0H, Sw, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S107" promotor_-35 325245..325252 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-35" promotor_-10 complement(325264..325283) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 325267..325286 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-10" upshifts complement(325277) /Source="Nicolas_upshifts" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" upshifts 325280 /Source="Nicolas_upshifts" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" promotor_-35 complement(325296..325302) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 325339..326772 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21747963, 21764931; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative branched chain amino acid permease" /protein_id="NP_388184.2" /db_xref="EnsemblGenomes-Gn:BSU03020" /db_xref="EnsemblGenomes-Tr:CAB12096" /db_xref="GOA:P55908" /db_xref="InterPro:IPR018385" /db_xref="SubtiList:BG11999" /db_xref="UniProtKB/Swiss-Prot:P55908" /translation="MSMPAAETQPKKKRMTFKMPDAYVLLFMIAFICAIASYIVPAGE FDRVTKGDVTTAVPGSYHSIEQSPVRLISFFTSLQDGMVGSAPIIFLILFTGGTIAIL EKTGAINGLIYNVISKFRTKQLLFICIVGALFSILGTTGIVVNSVIGFIPIGLIVARS LKWDAVAGAAVIYIGCYAGFNSTILSPSPLGLSQSIAELPLFSGIGLRVVIYICFLLS SIIYIYLYTRKLKKSKDASVLGTDWFPAAGMGEAGKEEDQSVPFTVRHKLILAVAGLS LVGFLYGALKLGWSDSQMAATFIFISVLAGLIGGLAANDIAKTFITGCQSLVYGALIV GMARSISVILENGKLLDTVVNALASLLDGFSPIAGAIGMYIASALLHFLISSGSGEAV VFIPILAPLADLMGITRQVAVEAVMLGEGVVNCVNPTSGVLMAVLAASGIPYVKWLRF MVPLALIWFLIGLVFIVIGVMINWGPF*" gene 325339..326772 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" promotor_-35 326077..326085 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 326097..326115 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 326116 /Source="Nicolas_upshifts" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 326754 /Source="Nicolas_upshifts" /id="D130" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="3.53497" /MaxDrop="3.31444" /score="12.0135493" /energy="-15.6" /TU="U217" /idTUdmin="U218" /TUdmin=0 /isTUend="TRUE" promotor_-35 326815..326822 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 326837..326856 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 326846 /Source="Nicolas_upshifts" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" CDS 326888..327469 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406, 22720735; Producttype m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_388185.2" /db_xref="EnsemblGenomes-Gn:BSU03030" /db_xref="EnsemblGenomes-Tr:CAB12097" /db_xref="SubtiList:BG12000" /db_xref="UniProtKB/Swiss-Prot:P55909" /translation="MNNLRNRLSGVNGKNKRVKEKEQKIWSEIGMIAGAFALLDVIIR GIMFEFPFKEWAASLVFLFIIILYYCIRAAASGMLMPRIDTKEELQKRVKQQRIESIA VAFAVVVLTMYDRGIPHTFFAWLKMILLFIVCGGVLFLLRYVIVKLAYRRAVKEEIKK KSSFLFGKRGKRSQFRAAFFIGTLICIHSAKLF*" gene 326888..327469 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" upshifts 327282 /Source="Nicolas_upshifts" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" misc_feature 327286..327290 /Source="Nicolas_upshift_promotors" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 327445..327452 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 327467..327486 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 327480..327617 /Source="Nicolas_S_feature" /locus_tag="new_327480_327617" /HighExp="BC, M0t90, M40t90, S2, M9-stat, T4.0H, Sw, T3.30H, Lbtran, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.999, 0.242, 0.999" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S108" upshifts 327480 /Source="Nicolas_upshifts" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" CDS 327618..329597 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" /EC_number="3.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3117969, 9353930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3117969, 9353930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-amylase" /protein_id="NP_388186.2" /db_xref="EnsemblGenomes-Gn:BSU03040" /db_xref="EnsemblGenomes-Tr:CAB12098" /db_xref="GOA:P00691" /db_xref="InterPro:IPR006046" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR031319" /db_xref="InterPro:IPR031965" /db_xref="PDB:1BAG" /db_xref="PDB:1UA7" /db_xref="SubtiList:BG10473" /db_xref="UniProtKB/Swiss-Prot:P00691" /translation="MFAKRFKTSLLPLFAGFLLLFHLVLAGPAAASAETANKSNELTA PSIKSGTILHAWNWSFNTLKHNMKDIHDAGYTAIQTSPINQVKEGNQGDKSMSNWYWL YQPTSYQIGNRYLGTEQEFKEMCAAAEEYGIKVIVDAVINHTTSDYAAISNEVKSIPN WTHGNTQIKNWSDRWDVTQNSLLGLYDWNTQNTQVQSYLKRFLDRALNDGADGFRFDA AKHIELPDDGSYGSQFWPNITNTSAEFQYGEILQDSASRDAAYANYMDVTASNYGHSI RSALKNRNLGVSNISHYASDVSADKLVTWVESHDTYANDDEESTWMSDDDIRLGWAVI ASRSGSTPLFFSRPEGGGNGVRFPGKSQIGDRGSALFEDQAITAVNRFHNVMAGQPEE LSNPNGNNQIFMNQRGSHGVVLANAGSSSVSINTATKLPDGRYDNKAGAGSFQVNDGK LTGTINARSVAVLYPDDIAKAPHVFLENYKTGVTHSFNDQLTITLRADANTTKAVYQI NNGPETAFKDGDQFTIGKGDPFGKTYTIMLKGTNSDGVTRTEKYSFVKRDPASAKTIG YQNPNHWSQVNAYIYKHDGSRVIELTGSWPGKPMTKNADGIYTLTLPADTDTTNAKVI FNNGSAQVPGQNQPGFDYVLNGLYNDSGLSGSLPH*" gene 327618..329597 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" downshifts 329611 /Source="Nicolas_upshifts" /id="D131" /incds=0 /nref=57 /ntot=131 /MaxReadThrough="1.64783" /MaxDrop="6.55823" /score="-8.82332571" /energy="-3.4" /TU="U221" /idTUdmin="U219" /TUdmin=0 /isTUend="TRUE" promotor_-35 329677..329684 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 329694 /Source="Nicolas_upshifts" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" promotor_-10 329698..329717 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 329774..330739 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" /EC_number="1.1.1.27" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10809684, 16207915, 19383131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 16207915, 19383131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lactate dehydrogenase" /protein_id="NP_388187.2" /db_xref="EnsemblGenomes-Gn:BSU03050" /db_xref="EnsemblGenomes-Tr:CAB12099" /db_xref="GOA:P13714" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011304" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR018177" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="PDB:3PQD" /db_xref="PDB:3PQE" /db_xref="PDB:3PQF" /db_xref="SubtiList:BG19003" /db_xref="UniProtKB/Swiss-Prot:P13714" /translation="MMNKHVNKVALIGAGFVGSSYAFALINQGITDELVVIDVNKEKA MGDVMDLNHGKAFAPQPVKTSYGTYEDCKDADIVCICAGANQKPGETRLELVEKNLKI FKGIVSEVMASGFDGIFLVATNPVDILTYATWKFSGLPKERVIGSGTTLDSARFRFML SEYFGAAPQNVHAHIIGEHGDTELPVWSHANVGGVPVSELVEKNDAYKQEELDQIVDD VKNAAYHIIEKKGATYYGVAMSLARITKAILHNENSILTVSTYLDGQYGADDVYIGVP AVVNRGGIAGITELNLNEKEKEQFLHSAGVLKNILKPHFAEQKVN*" gene 329774..330739 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" CDS 330771..332396 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10809684, 15849754, 16428414, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 15849754, 16428414, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_388188.2" /db_xref="EnsemblGenomes-Gn:BSU03060" /db_xref="EnsemblGenomes-Tr:CAB12100" /db_xref="GOA:P55910" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG12001" /db_xref="UniProtKB/Swiss-Prot:P55910" /translation="MWEQLYDPFGNEYVSALVALTPILFFLLALTVLKMKGILAAFLT LAVSFFVSVWAFHMPVEKAISSVLLGIGSGLWPIGYIVLMAVWLYKIAVKTGKFTIIR SSIAGISPDQRLQLLLIGFCFNAFLEGAAGFGVPIAISAALLVELGFKPLKAAALCLI ANAASGAFGAIGIPVITGAQIGDLSALELSRTLMWTLPMISFLIPFLLVFLLDRMKGI KQTWPALLVVSGGYTAVQTLTMAVLGPELANILAALFSMGGLALFLRKWQPKEIYREE GAGDAGEKKAYRAADIAKAWSPFYILTAAITIWSLPAFKALFQEGGLLYQSTLLFKMP FLHQQIMKMPPIAPSAMPLDAVFKVDLLSATGTAILAAVIVTGLFSKKFSSRDAFASL KETGKELWVPIMTICFVMGFANLANFAGLSSSIGLALAKTGDLFPFVSPVLGWIGVFI TGSVVSNNALFGHLQVVTGAQIGAGSDLLLAANTAGGVMAKLVSPQSIAIAAAAVGQT GKESKLFKRTVAYSLILLLIICIWTFILARLGV*" gene 330771..332396 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" downshifts 330777 /Source="Nicolas_upshifts" /id="D132" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="8.56142" /MaxDrop="2.8862" /score="-8.82332571" /energy="-3.4" /TU="U222" /idTUdmin="U221" /TUdmin=1144 /isTUend="FALSE" downshifts 332383 /Source="Nicolas_upshifts" /id="D133" /incds=0 /nref=51 /ntot=118 /MaxReadThrough="2.31168" /MaxDrop="7.73065" /score="39.575264" /energy="-15.6" /TU="NA" /idTUdmin="U222" /TUdmin=0 /isTUend="TRUE" CDS complement(332441..333979) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9023234, 15489457, 15849754, 16850406, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023234, 15489457, 15849754, 16850406, 21690368; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_388189.2" /db_xref="EnsemblGenomes-Gn:BSU03070" /db_xref="EnsemblGenomes-Tr:CAB12101" /db_xref="GOA:P96712" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12002" /db_xref="UniProtKB/Swiss-Prot:P96712" /translation="MDTTTAKQASTKFVVLGLLLGILMSAMDNTIVATAMGNIVADLG SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLIFFLIGSALCGIAQTMNQ LIIFRAIQGIGGGALLPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGAIIT DSISWHWVFYINVPIGALSLFFIIRYYKESLEHRKQKIDWGGAITLVVSIVCLMFALE LGGKTYDWNSIQIIGLFIVFAVFFIAFFIVERKAEEPIISFWMFKNRLFATAQILAFL YGGTFIILAVFIPIFVQAVYGSSATSAGFILTPMMIGSVIGSMIGGIFQTKASFRNLM LISVIAFFIGMLLLSNMTPDTARVWLTVFMMISGFGVGFNFSLLPAASMNDLEPRFRG TANSTNSFLRSFGMTLGVTIFGTVQTNVFTNKLNDAFSGMKGSAGSGAAQNIGDPQEI FQAGTRSQIPDAILNRIIDAMSSSITYVFLLALIPIVLAAVTILFMGKARVKTTAEMT KKAN*" gene complement(332441..333979) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" downshifts complement(332459) /Source="Nicolas_upshifts" /id="D134" /incds=0 /nref=70 /ntot=182 /MaxReadThrough="1.04964" /MaxDrop="4.53635" /score="30.8374042" /energy="-15.6" /TU="NA" /idTUdmin="U225" /TUdmin=0 /isTUend="TRUE" promotor_no_box complement(333033..333133) /Source="Nicolas_upshift_promotors" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(333073) /Source="Nicolas_upshifts" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 333993..333997 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 334013..334032 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 334027 /Source="Nicolas_upshifts" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" promotor_-10 complement(334059..334078) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(334062) /Source="Nicolas_upshifts" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" CDS 334092..334556 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388190.2" /db_xref="EnsemblGenomes-Gn:BSU03080" /db_xref="EnsemblGenomes-Tr:CAB12102" /db_xref="GOA:O31472" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12003" /db_xref="UniProtKB/Swiss-Prot:O31472" /translation="MSTRNSRSELEKTAVQLFRKLGTRTVLFHQAAAQALGLFPTDLK SADILNEAGPMTAGELGKKTGLSTGSVTALVDRLEKAGYVAREKDPNDRRRVVIVPLT ASKKHIKDLFRPLSESTMDLCREYTEEELELIFSFVGKAADIMEEELERLKQ*" gene 334092..334556 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" promotor_-35 complement(334093..334099) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 334566..334571 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 334587..334605 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 334597 /Source="Nicolas_upshifts" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" CDS 334630..335259 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid export permease" /protein_id="NP_388191.1" /db_xref="EnsemblGenomes-Gn:BSU03090" /db_xref="EnsemblGenomes-Tr:CAB12103" /db_xref="GOA:P94381" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG12004" /db_xref="UniProtKB/Swiss-Prot:P94381" /translation="MNIFLSYIVLGLSLSAPVGPVNAAQIDKGIKNGFWHAWIFGLGA MTADGLYMLFIYFGLSQFLTAPFVKTFLWLFGFFVLTYTGIETLKNVREPMDVRSSRG KPSYRKTFASGFLISLSNPLSILFWLGIYGSILAKTAEAYNMNQLLIYSSGIMIGILI WDFCMAITASTFRNLLHEKLLRGLTGIAGVSLLVFGFYFGYQGIKQLLG*" gene 334630..335259 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" promotor_-35 335270..335279 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 335293..335312 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 335301 /Source="Nicolas_upshifts" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" CDS 335329..336090 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (similar to phage protein)" /protein_id="NP_388192.2" /db_xref="EnsemblGenomes-Gn:BSU03100" /db_xref="EnsemblGenomes-Tr:CAB12104" /db_xref="InterPro:IPR014988" /db_xref="SubtiList:BG12005" /db_xref="UniProtKB/Swiss-Prot:P94382" /translation="MVNGIYTKSFLERIQEELPEWQRIAFELLAETLGDDADTFPCIP GRQAFLTDQLRIAFAGDPRENRTAEELAPLLAEYGKISRDTGKYASLVVLFDTPEDLA EHYSIEAYEELFWRFLNRLSHQDEKEWPEDIPADPEHYKWEFCFDGEPYFILCATPGH EARRSRSFPFFMVTFQPRWVFDDLNGSTAFGRNMSRLIRSRLEAYDQAPIHPQLGWYG GKDNREWKQYFLRDDEKQVSKCPFSYLKNMFNKMK*" gene 335329..336090 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" S_feature complement(335729..336091) /Source="Nicolas_S_feature" /locus_tag="new_335729_336091_c" /HighExp="S8, S7, S5, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="ycgG" /AntisenseCor="0.73875580854115197" /AntisenseRegPval="-46.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S109" downshifts 336087 /Source="Nicolas_upshifts" /id="D135" /incds=0 /nref=21 /ntot=174 /MaxReadThrough="1.53211" /MaxDrop="4.92685" /score="6.36985882" /energy="-8.6" /TU="NA" /idTUdmin="U227" /TUdmin="-6" /isTUend="TRUE" CDS complement(336092..337432) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid transporter" /protein_id="NP_388193.2" /db_xref="EnsemblGenomes-Gn:BSU03110" /db_xref="EnsemblGenomes-Tr:CAB12105" /db_xref="GOA:P94383" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12006" /db_xref="UniProtKB/Swiss-Prot:P94383" /translation="MSQTKKDQPKGNLAWWQLSLIGVGCTIGTGFFLGSSIAIVKSGF SVLLSFLIAGIGTYFVFEQLAKLSAKQPEKGSFCAYARKAFGKWAGFSNGWVYWTSEM LITGSQLTAISLFTKHWFPQVPLWVFASIYAVLGLLIIFTGLSVFEKTENVLAVIKTA AIFMFIVIAILALCGILSGGNHGIHVPNKTSEFFPYGAMGLWTGLIYAFYAFGGIEVM GLMAVHLKKPEEASKSGKLMLATLAIIYIISIGLALLLVPLHTFTEQDSPFITSLKGY NLEIILDIFNGIFIIAGFSTLVASLFAVTTLLCTMADDGDAPKCFTLKEGKKICWPAL GLTFAGLVLSIILSLVLPKNIYEHMTTAAGLMLLYTWLFILFSSKKLTDPEGMGKTQI YLAMVLIAAAVSGTLFEKSSRPGFFVSIGFLVIIAIVTMIYQKKQGHKDRPASP*" gene complement(336092..337432) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" promotor_-10 complement(337459..337470) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(337469) /Source="Nicolas_upshifts" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" promotor_-35 complement(337485..337491) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 337511..337517 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 337525 /Source="Nicolas_upshifts" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" promotor_-10 337532..337543 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 337562..338158 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 16433904, 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388194.3" /db_xref="EnsemblGenomes-Gn:BSU03120" /db_xref="EnsemblGenomes-Tr:CAB12106" /db_xref="InterPro:IPR018959" /db_xref="SubtiList:BG12007" /db_xref="UniProtKB/Swiss-Prot:O31473" /translation="MTQQYIVEPKKGLGLKLKKGQILKVVDVEGQQVADFVAYHAKDF YEHLDQGATIDANHSIHVKVNDHLYSNLYKPMLTLIEDTVGKHDLLLPACRPDMNRLL YGKQKDEFQDTCYDNMNRALEQFGVPKPHMHYPFAIFMNTVLDEKGNLSVETPLSNAG DYVRLRAEMDLIVAFSSCPIEKGKCNGDSVTSIRVEVS*" gene 337562..338158 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" promotor_-35 338166..338173 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 338187..338287 /Source="Nicolas_S_feature" /locus_tag="new_338187_338287" /HighExp="dia15, LBGtran, dia5, Etha, dia0, LBGexp, M0t45, Lbexp, Diami, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S110" promotor_-10 338187..338206 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 338187 /Source="Nicolas_upshifts" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" downshifts complement(338283) /Source="Nicolas_upshifts" /id="D136" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="1.2989" /MaxDrop="4.67402" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=1562 /isTUend="FALSE" CDS 338288..339106 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" /EC_number="6.3.1.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7890752, 9271869, 12682299, 19204287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7890752, 9271869, 12682299, 19204287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ammonium-dependent NAD+ synthetase" /protein_id="NP_388195.1" /db_xref="EnsemblGenomes-Gn:BSU03130" /db_xref="EnsemblGenomes-Tr:CAB12107" /db_xref="GOA:P08164" /db_xref="InterPro:IPR003694" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022926" /db_xref="PDB:1EE1" /db_xref="PDB:1FYD" /db_xref="PDB:1IFX" /db_xref="PDB:1IH8" /db_xref="PDB:1KQP" /db_xref="PDB:1NSY" /db_xref="PDB:2NSY" /db_xref="SubtiList:BG10694" /db_xref="UniProtKB/Swiss-Prot:P08164" /translation="MSMQEKIMRELHVKPSIDPKQEIEDRVNFLKQYVKKTGAKGFVL GISGGQDSTLAGRLAQLAVESIREEGGDAQFIAVRLPHGTQQDEDDAQLALKFIKPDK SWKFDIKSTVSAFSDQYQQETGDQLTDFNKGNVKARTRMIAQYAIGGQEGLLVLGTDH AAEAVTGFFTKYGDGGADLLPLTGLTKRQGRTLLKELGAPERLYLKEPTADLLDEKPQ QSDETELGISYDEIDDYLEGKEVSAKVSEALEKRYSMTEHKRQVPASMFDDWWK*" gene 338288..339106 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" downshifts 339088 /Source="Nicolas_upshifts" /id="D137" /incds=0 /nref=144 /ntot=271 /MaxReadThrough="2.68866" /MaxDrop="6.24927" /score="20.6612287" /energy="-14.1" /TU="U230" /idTUdmin="U230" /TUdmin="-65" /isTUend="FALSE" CDS complement(339156..339749) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1624425, 7766032, 15131133, 27315722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624425, 7766032, 15131133, 27315722; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATP-binding tunicamycin resistance protein" /protein_id="NP_388196.2" /db_xref="EnsemblGenomes-Gn:BSU03140" /db_xref="EnsemblGenomes-Tr:CAB12108" /db_xref="GOA:P12921" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10456" /db_xref="UniProtKB/Swiss-Prot:P12921" /translation="MIIWINGAFGSGKTQTAFELHRRLNPSYVYDPEKMGFALRSMVP QEIAKDDFQSYPLWRAFNYSLLASLTDTYRGILIVPMTIVHPEYFNEIIGRLRQEGRI VHHFTLMASKETLLKRLRTRAEGKNSWAAKQIDRCVEGLSSPIFEDHIQTDNLSIQDV AENIAARAELPLDPDTRGSLRRFADRLMVKLNHIRIK*" gene complement(339156..339749) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" downshifts complement(339163) /Source="Nicolas_upshifts" /id="D138" /incds=0 /nref=10 /ntot=143 /MaxReadThrough="0.60282" /MaxDrop="3.74815" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=682 /isTUend="FALSE" promotor_-10 complement(339764..339783) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(339779) /Source="Nicolas_upshifts" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(339798..339801) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(339807..339955) /Source="Nicolas_S_feature" /locus_tag="new_339807_339955_c" /HighExp="S4, S3, S6, S5, S7, BT, S8, LoTm, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S111" promotor_-35 339857..339864 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 339877..339896 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 339879..339987 /Source="Nicolas_S_feature" /locus_tag="new_339879_339987" /HighExp="Diami, BMM, GM 15, GM 25, GM 120, GM 60, GM 10, G180, GM 45, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S112" upshifts 339881 /Source="Nicolas_upshifts" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" promotor_-10 complement(339949..339967) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 339955..339962 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(339965) /Source="Nicolas_upshifts" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" promotor_-10 339977..339996 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(339983..339988) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 339989 /Source="Nicolas_upshifts" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" CDS 340025..340585 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" /EC_number="2.7.1.71" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 170268, 7612934, 27339308; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate kinase" /protein_id="NP_388197.2" /db_xref="EnsemblGenomes-Gn:BSU03150" /db_xref="EnsemblGenomes-Tr:CAB12109" /db_xref="GOA:P37944" /db_xref="InterPro:IPR000623" /db_xref="InterPro:IPR023000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031322" /db_xref="SubtiList:BG10457" /db_xref="UniProtKB/Swiss-Prot:P37944" /translation="MNAKRAIPVRERNIVLIGFMGVGKTTIGQLVAKKLYRDFIDIDQ QIEKDFNMSIPEIFEKKGEDFFRKTEKEYILDICHHKRFKIVSLGGGSFKQEEIRNCC LENCLVLHLDLSWENWKQRADLLIESRPVLHNRSMDEMEQLFNERKVIYDKHNSKVAT DNLSPEEVADYIVETLKIGWDLYQPM*" gene 340025..340585 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" downshifts 340562 /Source="Nicolas_upshifts" /id="D139" /incds=0 /nref=21 /ntot=239 /MaxReadThrough="2.07607" /MaxDrop="4.67156" /score="44.9099474" /energy="-13.1" /TU="NA" /idTUdmin="U232" /TUdmin=1 /isTUend="TRUE" CDS complement(340613..341374) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388198.2" /db_xref="EnsemblGenomes-Gn:BSU03160" /db_xref="EnsemblGenomes-Tr:CAB12110" /db_xref="GOA:O31474" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XXL" /db_xref="PDB:2GLU" /db_xref="SubtiList:BG12008" /db_xref="UniProtKB/Swiss-Prot:O31474" /translation="MTNETPFSKNAEMYRDEKVFAEGEDLGLMIKTAECRAEHRVLDI GAGAGHTALAFSPYVQECIGVDATKEMVEVASSFAQEKGVENVRFQQGTAESLPFPDD SFDIITCRYAAHHFSDVRKAVREVARVLKQDGRFLLVDHYAPEDPVLDEFVNHLNRLR DPSHVRESSLSEWQAMFSANQLAYQDIQKWNLPIQYDSWIKRGGTPADREKQIITHLN HASDEARDTFCITLNQNGQPISFCLKAILIQGIKR*" gene complement(340613..341374) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" downshifts complement(340637) /Source="Nicolas_upshifts" /id="D140" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.31391" /MaxDrop="3.85249" /score="18.9843263" /energy="-13.1" /TU="NA" /idTUdmin="U235" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(341406..341425) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 341407..341414 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(341412) /Source="Nicolas_upshifts" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" promotor_-10 341429..341448 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(341440..341445) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 341441 /Source="Nicolas_upshifts" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" CDS 341492..342466 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_388199.2" /db_xref="EnsemblGenomes-Gn:BSU03170" /db_xref="EnsemblGenomes-Tr:CAB12111" /db_xref="GOA:P94387" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12009" /db_xref="UniProtKB/Swiss-Prot:P94387" /translation="MDIKVMEYAAEIARRQSFTKAAEHLHIAQPSLSQQIKKLEAELG LTLFHRSHGSVTLTPHGRRFIEKAEDIIRSRDDLLREMQERSQGIGHKLSIGIPAVTG RYLFPPLLKQFLARYPHVEVQLVEKDPVSLEKMTAKGEVDLSVLSLPIEDERLSITPL LTEPVVLAVPKEKQRWMPPELVALIEKALEEDEGRQPCVPIDMVRNVPFILLKEGFGF RRTVLDLCAESGFKPNAAFKTSHIETAQSLVANGLGVTMAPNMVRRDKDPGVIYLSIQ SAPSRTLVFVFLKNRYVSLTAQAFMELSRESLKQTFDEGCLGNKDENI*" gene 341492..342466 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" S_feature 342467..342537 /Source="Nicolas_S_feature" /locus_tag="new_342467_342537" /HighExp="Diami, dia5, dia15, S1, dia0, C90, LBGexp, Heat, Lbexp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S113" CDS 342538..343494 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" /EC_number="3.1.1.41" /EC_number="3.1.1.72" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12842474, 19837798, 21382014" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12842474, 19837798, 21382014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acetyl xylan esterase-cephalosporin C deacetylase" /protein_id="NP_388200.1" /db_xref="EnsemblGenomes-Gn:BSU03180" /db_xref="EnsemblGenomes-Tr:CAB12112" /db_xref="GOA:P94388" /db_xref="InterPro:IPR008391" /db_xref="InterPro:IPR029058" /db_xref="PDB:1L7A" /db_xref="PDB:1ODS" /db_xref="PDB:1ODT" /db_xref="SubtiList:BG11919" /db_xref="UniProtKB/Swiss-Prot:P94388" /translation="MQLFDLPLDQLQTYKPEKTAPKDFSEFWKLSLEELAKVQAEPDL QPVDYPADGVKVYRLTYKSFGNARITGWYAVPDKEGPHPAIVKYHGYNASYDGEIHEM VNWALHGYATFGMLVRGQQSSEDTSISPHGHALGWMTKGILDKDTYYYRGVYLDAVRA LEVISSFDEVDETRIGVTGGSQGGGLTIAAAALSDIPKAAVADYPYLSNFERAIDVAL EQPYLEINSFFRRNGSPETEVQAMKTLSYFDIMNLADRVKVPVLMSIGLIDKVTPPST VFAAYNHLETKKELKVYRYFGHEYIPAFQTEKLAFFKQHLKG*" gene 342538..343494 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" promotor_-35 342953..342959 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 342974..342985 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 342981 /Source="Nicolas_upshifts" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" S_feature 343495..343573 /Source="Nicolas_S_feature" /locus_tag="new_343495_343573" /HighExp="dia5, dia15, Diami, dia0, B36, S1, MG 10, BT, B60, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S114" promotor_-35 343548..343553 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 343570..343588 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 343575 /Source="Nicolas_upshifts" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" CDS 343578..344360 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388201.1" /db_xref="EnsemblGenomes-Gn:BSU03190" /db_xref="EnsemblGenomes-Tr:CAB12113" /db_xref="InterPro:IPR018775" /db_xref="SubtiList:BG12010" /db_xref="UniProtKB/Swiss-Prot:P94389" /translation="MKQRIIDELKRIEQSYGVKIVYAVESGSRAWGFPSQDSDYDVRF IYVPKKEWYFSIEQERDVIEEPIHDLLDISGWELRKTLRLFKKSNPPLLEWLSSDIVY YEAFTTAEQLRKLRTEAFKPEASVYHYINMARRNVKDYLQGQEVKIKKYFYVLRPILA CQWIEKHGTIPPMDFTVLMNELVAEPELKAEMETLLERKRRGEELDLEARIDVIHQFI ETEIERIMEAAKELKAEKKDMTSELNRLLLNTVEEVWKDGGS*" gene 343578..344360 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" downshifts 344325 /Source="Nicolas_upshifts" /id="D141" /incds=0 /nref=11 /ntot=63 /MaxReadThrough="3.94077" /MaxDrop="4.37398" /score="0.421649027" /energy="-5.9" /TU="U238" /idTUdmin="U236" /TUdmin=2 /isTUend="TRUE" S_feature 344370..344497 /Source="Nicolas_S_feature" /locus_tag="new_344370_344497" /HighExp="S5, S6, S8, S4, S7, B36, B60, BT, S3, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S115" promotor_-35 344474..344478 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 344493..344512 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 344499 /Source="Nicolas_upshifts" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" CDS 344551..345462 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" /EC_number="1.5.5.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17536821, 2118500, 21840319, 22139509, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17536821, 2118500, 21840319, 22139509, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline oxidase" /protein_id="NP_388202.1" /db_xref="EnsemblGenomes-Gn:BSU03200" /db_xref="EnsemblGenomes-Tr:CAB12114" /db_xref="GOA:P94390" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG12011" /db_xref="UniProtKB/Swiss-Prot:P94390" /translation="MITRDFFLFLSKSGFLNKMARNWGSRVAAGKIIGGNDFNSSIPT IRQLNSQGLSVTVDHLGEFVNSAEVARERTEECIQTIATIADQELNSHVSLKMTSLGL DIDMDLVYENMTKILQTAEKHKIMVTIDMEDEVRCQKTLDIFKDFRKKYEHVSTVLQA YLYRTEKDIDDLDSLNPFLRLVKGAYKESEKVAFPEKSDVDENYKKIIRKQLLNGHYT AIATHDDKMIDFTKQLAKEHGIANDKFEFQMLYGMRSQTQLSLVKEGYNMRVYLPYGE DWYGYFMRRLAERPSNIAFAFKGMTKK*" gene 344551..345462 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" CDS 345479..347026 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 17183215, 21840319, 22139509, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 17183215, 21840319, 22139509, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-pyrroline-5-carboxylate dehydrogenase" /protein_id="NP_388203.2" /db_xref="EnsemblGenomes-Gn:BSU03210" /db_xref="EnsemblGenomes-Tr:CAB12115" /db_xref="GOA:P94391" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12012" /db_xref="UniProtKB/Swiss-Prot:P94391" /translation="MTTPYKHEPFTNFQDQNNVEAFKKALATVSEYLGKDYPLVINGE RVETEAKIVSINPADKEEVVGRVSKASQEHAEQAIQAAAKAFEEWRYTSPEERAAVLF RAAAKVRRRKHEFSALLVKEAGKPWNEADADTAEAIDFMEYYARQMIELAKGKPVNSR EGEKNQYVYTPTGVTVVIPPWNFLFAIMAGTTVAPIVTGNTVVLKPASATPVIAAKFV EVLEESGLPKGVVNFVPGSGAEVGDYLVDHPKTSLITFTGSREVGTRIFERAAKVQPG QQHLKRVIAEMGGKDTVVVDEDADIELAAQSIFTSAFGFAGQKCSAGSRAVVHEKVYD QVLERVIEITESKVTAKPDSADVYMGPVIDQGSYDKIMSYIEIGKQEGRLVSGGTGDD SKGYFIKPTIFADLDPKARLMQEEIFGPVVAFCKVSDFDEALEVANNTEYGLTGAVIT NNRKHIERAKQEFHVGNLYFNRNCTGAIVGYHPFGGFKMSGTDSKAGGPDYLALHMQA KTISEMF*" gene 345479..347026 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" promotor_-35 346450..346456 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 346470..346489 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 346478 /Source="Nicolas_upshifts" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" promotor_-35 346561..346567 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 346580..346599 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 346589 /Source="Nicolas_upshifts" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" misc_feature 347025..347029 /Source="Nicolas_upshift_promotors" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 347027..347149 /Source="Nicolas_S_feature" /locus_tag="new_347027_347149" /HighExp="S1, T2.0H, T2.30H, Lbstat, aero, HiOs, BC, Sw, LPh, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52312199999999998" /TUshortSig="Sig-, SigA, SigA, SigA, SigEF" /TUshortPSig="0.249, 1, 0.994, 0.922, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S116" upshifts 347029 /Source="Nicolas_upshifts" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" CDS 347150..348571 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline permease" /protein_id="NP_388204.2" /db_xref="EnsemblGenomes-Gn:BSU03220" /db_xref="EnsemblGenomes-Tr:CAB12116" /db_xref="GOA:P94392" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12013" /db_xref="UniProtKB/Swiss-Prot:P94392" /translation="MLLIGYFAYKRTSNLTDYMLGGRSLGPAVTALSAGAADMSGWLL MGLPGAMFSTGLSGAWIVIGLCLGAWANWLYVAPRLRTYTEKAGNSITIPGFLENRFG DQTKLLRLFSGIVILVFFTFYVSSGMVSGGVLFNSILGMDYHTGLWIVTGVVVAYTLF GGFLAVSWTDFVQGIIMFAALILVPIVTFFHTGGAGDTVAEIRSVDPDMFNIFKGTSV LGIISLFAWGLGYFGQPHIIVRFMAITSVKEIKRARRIGMGWMILSAVGAVLTGLGGI AYYHQRGMTLKDPETIFIQLGNILFHPIITGFLISAILAAIMSTISSQLLVTSSSLVE DLYKSMFRRSASDKELVFLGRLAVLAVSIVALVLAWEKNNTILGLVSYAWAGFGASFG PVVLLSLFWKRMTKWGALAGMIVGAATVIIWANAGLSDFLYEMIPGFAASLLSVFFVS ILTQAPSQAVTDQFNDYQDTMSQ*" gene 347150..348571 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" S_feature complement(347670..349525) /Source="Nicolas_S_feature" /locus_tag="new_347670_349525_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, C30, T4.0H, Lbstat" /AntisenseName="ycgP" /AntisenseCor="0.143781082577395" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.679" /TUlongSig="NA" /TUlongPSig="NA" /label="S117" downshifts 348551 /Source="Nicolas_upshifts" /id="D142" /incds=0 /nref=21 /ntot=160 /MaxReadThrough="5.09597" /MaxDrop="4.17771" /score="5.89792272" /energy="-15.9" /TU="U239,U240,U242" /idTUdmin="U238" /TUdmin=4 /isTUend="TRUE" S_feature 348596..348692 /Source="Nicolas_S_feature" /locus_tag="new_348596_348692" /HighExp="S1, LPh, T2.0H, HPh, aero, Lbstat, LoTm, T2.30H, Cold, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.249, 0.994, 0.922" /TUlongSig="NA" /TUlongPSig="NA" /label="S118" promotor_-35 348663..348670 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 348685..348704 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 348694 /Source="Nicolas_upshifts" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" CDS 348724..349959 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21840319, 21964733, 22139509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21840319, 21964733, 22139509; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of proline degradationoperon" /protein_id="NP_388205.2" /db_xref="EnsemblGenomes-Gn:BSU03230" /db_xref="EnsemblGenomes-Tr:CAB12117" /db_xref="GOA:P94393" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12014" /db_xref="UniProtKB/Swiss-Prot:P94393" /translation="MEELLERVFSFSDVDKLIDFISYELQKPVILESADFFLLAYNSY YINHFDSANQQTIFSKKCPVQIFERFLKDGIIEKLKTEPEPFRVNKIESIGLNQRVVV SAKHKGEVMGYIWIQELDQNLTDEELDFLYETSFHVGKIIYKTNKLKQEKEEKAEDLI KRAIYQQFTSEKELRREAERINTVLPSMFSVVILHAANGDGEAVEDLKENIRSYLNLR DKVSHVLTIESNIVIVVASFSQKSSVSSAASEFINKLLTHFHFQKIPTPIYIGIGNEY NHLLKLGKSYTEALEVIKAAEITGNQENIPYEYAKLGIYRYLESIEQKNEFLEYENKD LALLKAKDEESSTELLKTLEIYLLNNCKTKPAAEQLFIHQNTLNYRIKQITEMTSIDL SDFRTRCQLYLDLMLMKKK*" gene 348724..349959 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" promotor_-10 complement(349518..349536) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(349535) /Source="Nicolas_upshifts" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" promotor_-35 complement(349550..349557) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(349943) /Source="Nicolas_upshifts" /id="D143" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="0.0291099999999993" /MaxDrop="3.08474" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=66 /isTUend="FALSE" CDS complement(349996..350853) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388206.1" /db_xref="EnsemblGenomes-Gn:BSU03240" /db_xref="EnsemblGenomes-Tr:CAB12118" /db_xref="GOA:P94394" /db_xref="InterPro:IPR015402" /db_xref="SubtiList:BG12015" /db_xref="UniProtKB/Swiss-Prot:P94394" /translation="MFRLLVLMGFTFFFYHLHASGNLTKYINMKYAYLSFIAIFLLAI LTAVQAYLFIKSPEKSGHHHDHDCGCGHDHEHDHEQNKPFYQRYLIYVVFLFPLVSGI FFPIATLDSSIVKTKGFSFKAMESGDHYSQTQYLRPDASLYYAQDSYDKQMKQLFNKY SSKKEISLTDDDFLKGMETIYNYPGEFLGRTIEFHGFAYKGNAINKNQLFVLRFGIIH CIADSGVYGMLVEFPKDMDIKDDEWIHIKGTLASEYYQPFKSTLPVVKVTDWNTIKKP DDPYVYRGF*" gene complement(349996..350853) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" downshifts complement(350009) /Source="Nicolas_upshifts" /id="D144" /incds=0 /nref=48 /ntot=167 /MaxReadThrough="1.97725" /MaxDrop="4.53007" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=0 /isTUend="TRUE" CDS complement(350858..351742) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388207.1" /db_xref="EnsemblGenomes-Gn:BSU03250" /db_xref="EnsemblGenomes-Tr:CAB12119" /db_xref="GOA:P94395" /db_xref="InterPro:IPR005524" /db_xref="SubtiList:BG12016" /db_xref="UniProtKB/Swiss-Prot:P94395" /translation="MTAQSSFLQLNSIFISILIEAIPFILIGVILSGIIQMFVSEEMI ARIMPKNRFLAVLFGALAGVLFPACECGIIPITRRLLLKGVPLHAGVAFMLTAPIINP IVLFSTYIAFGNRWSVVFYRGGLALAVSLIIGVILSYQFKDNQLLKPDEPGHHHHHHG TLLQKLGGTLRHAIDEFFSVGKYLIIGAFIAAAMQTYVKTSTLLAIGQNDVSSSLVMM GLAFVLSLCSEVDAFIASSFSSTFSLGSLIAFLVFGAMVDIKNLLMMLAAFKKRFVFL LITYIVVIVLAGSLLVKG*" gene complement(350858..351742) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" upshifts complement(351794) /Source="Nicolas_upshifts" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" promotor_-10 complement(351799..351812) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(351827..351835) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(351842..352696) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" /EC_number="3.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic hydrocarbon hydrolase" /protein_id="NP_388208.1" /db_xref="EnsemblGenomes-Gn:BSU03260" /db_xref="EnsemblGenomes-Tr:CAB12120" /db_xref="GOA:P94396" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12017" /db_xref="UniProtKB/Swiss-Prot:P94396" /translation="MKRRVETITFDGGTLEYSVTGKGTPILVMHGGHSNCYEEFGYTA LIEQGYSIITPSRPGYGRTSKEIGKSLANACRFYVKLLDHLQIESVHVIAISAGGPSG ICFASHYPERVNTLTLQSAVTKEWLTPKDTEYKLGEILFRPPVEKWIWKLISSLNNAF PRLMFRAMSPQFSTLPFQRIKSLMNEKDIEAFRKMNSRQRSGEGFLIDLSQTAAVSLK DLQAIICPVLIMQSVYDGLVDLSHAHHAKEHIRGAVLCLLHSWGHLIWLGKEAAETGS ILLGFLES*" gene complement(351842..352696) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" promotor_-10 complement(352715..352734) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-10" upshifts complement(352735) /Source="Nicolas_upshifts" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" promotor_-35 complement(352749..352752) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-35" misc_feature 352786..352805 /Source="Nicolas_upshift_promotors" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(352786..352804) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 352793..352857 /Source="Nicolas_S_feature" /locus_tag="new_352793_352857" /HighExp="B60, Lbexp, LBGexp, dia0, B36, HiOs, GM 15, GM 10, Salt, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S119" upshifts 352794 /Source="Nicolas_upshifts" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" upshifts complement(352803) /Source="Nicolas_upshifts" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(352820..352825) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 352858..353868 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" /EC_number="1.18.1.-" /EC_number="1.8.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16672620, 25826316" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 25826316; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Fur-regulated NADPH:ferredoxin oxidoreductase" /protein_id="NP_388209.1" /db_xref="EnsemblGenomes-Gn:BSU03270" /db_xref="EnsemblGenomes-Tr:CAB12121" /db_xref="GOA:O31475" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12018" /db_xref="UniProtKB/Swiss-Prot:O31475" /translation="MAENQEVYDVTIIGGGPIGLFTAFYCGMRELKTKVIEFLPKLGG KVSLFFPEKIIRDIGGIPGIAGKQLIEQLKEQAATFDPDIVLNQRVTGFERLDDGTIV LTGSEGKKHYTRTVILACGMGTLEVNEFDSEDAARYAGKNLHYGVEKLDAFKGKRVVI SGGGDTAVDWANELEPIAASVTVVHRREEFGGMESSVTKMKQSSVRVLTPYRLEQLNG DEEGIKSVTVCHTESGQRKDIEIDELIINHGFKIDLGPMMEWGLEIEEGRVKADRHMR TNLPGVFVAGDAAFYESKLRLIAGGFTEGPTAVNSAKAYLDPKAENMAMYSTHHKKLV HK*" gene 352858..353868 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" S_feature 353869..356316 /Source="Nicolas_S_feature" /locus_tag="new_353869_356316" /HighExp="B60, Lbexp, GM 10, GM 25, HiOs, GM 15, dia0, GM 45, LBGexp, H2O2" /AntisenseName="nasF" /AntisenseCor="-0.30348565853404702" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S120" CDS complement(353900..355351) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" /EC_number="2.1.1.107" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9765565, 10217486, 15028686" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765565, 10217486, 15028686; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrin-III C-methyltransferase" /protein_id="NP_388210.1" /db_xref="EnsemblGenomes-Gn:BSU03280" /db_xref="EnsemblGenomes-Tr:CAB12122" /db_xref="GOA:P42437" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR012409" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG11098" /db_xref="UniProtKB/Swiss-Prot:P42437" /translation="MIMKNGIVYFVGAGPGDPGLLTIKGKQALKEADVILYDRLANPK LLEFASPDCQFIYCGKLPNRHFMKQKEINALLVEKALNGLTVVRLKGGDPSVFGRVGE EADALHEHGIRYEMVPGITSGIAAPLYAGIPVTHRDFASSFAMITAHDKSLKGTPNLD WEGLARSVQTLVFYMGVKNLSYICQQLISYGKSPSVPVIVIQWGTWGRQRSVKGTLEN IQQKVQEHQITNPAIIVIGDIVNFQTHSWFESKPLIGRHLMVVTHGEDEDPLADKLRD SGADLIEWPKWRTENMPVNEEILRKIGTFEDVFFTSRRAVCEFFRALASQKIDIRQLT AKLSAASEQAKTELEKRGFLVTAIQPDSEKRLVVGSRHAVENMQKHESCSFYITHENV IDDRFTHMIQRTISESPLHMVICPNKLSVQQLINGGEQIGILPEPSASRPPIVCIGDD SAAGIYGFTAVQEQDELLAFIHNQHAEKKLLHT*" gene complement(353900..355351) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" downshifts complement(353904) /Source="Nicolas_upshifts" /id="D145" /incds=0 /nref=131 /ntot=230 /MaxReadThrough="1.40657" /MaxDrop="6.58881" /score="10.9556399" /energy="-11.7" /TU="NA" /idTUdmin="U250" /TUdmin="-1" /isTUend="TRUE" CDS complement(355412..355732) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 15028686, 9765565, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 15028686, 9765565, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388211.1" /db_xref="EnsemblGenomes-Gn:BSU03290" /db_xref="EnsemblGenomes-Tr:CAB12123" /db_xref="GOA:P42436" /db_xref="InterPro:IPR012748" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11097" /db_xref="UniProtKB/Swiss-Prot:P42436" /translation="MVNKDVTKVCIGKIEELPEQLGKTVYIEDKELAVFKLSDGSIRA IENRCPHKGGVLAEGIVSGQYVFCPMHDWKISLEDGIVQEPDHGCVKTYETLIEGEHV YLVY*" gene complement(355412..355732) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" promotor_-35 355583..355588 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 355602..355606 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 355609 /Source="Nicolas_upshifts" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(355641) /Source="Nicolas_upshifts" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" promotor_-10 complement(355643..355662) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(355676..355683) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(355764..358181) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565, 16428414, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565, 16428414, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388212.1" /db_xref="EnsemblGenomes-Gn:BSU03300" /db_xref="EnsemblGenomes-Tr:CAB12124" /db_xref="GOA:P42435" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11096" /db_xref="UniProtKB/Swiss-Prot:P42435" /translation="MGKKQLVLVGNGMAGVRAIEEILSVAKDEFQITIFGAEPHPNYN RILLSKVLQGDTDIKDITLNDWDWYEENNIQLYTNETVIKVDTENKTVITDADRIQPY DELILATGSVPFILPIPGADKKGVTAFRDIKDTDTMLAASKQYKKAAVIGGGLLGLEA ARGLLNLGMDVSVIHLAPFLMERQLDATAGRLLQNELEKQGMTFLLEKQTEEIVGDDR VEGLRFKDGTSIEADLVVMAVGIRPNTTLGAESGIPVNRGIIVNDYMQTEIPHIYAVG ECAEHRGIAYGLVAPLYEQAKVLAKHMCGIETKPYEGSVLSTQLKVSGVEVFSAGDFN ESEEKKAIKVFDEQDGIYKKIVLRGNQIVGAVLFGDSSEGNRLFSMIQKEADISETSK ISILQPLSQEAGTSITAAMSDDEIICGCNGVSKGAIIQAIQEKGCSSTDEIKACTGAS RSCGGCKPLVEEILQHTLGSDFDASAQKEAICGCTTLSRDEVVEEIKAKGLSHTREVM NVLGWKTPEGCSKCRPALNYYLGMINPTKYEDDRTSRFVNERMHANIQKDGTYSVVPR MYGGVTNSTDLRKIADVVDKYEIPLVKMTGGQRIDLIGVKKEDLPKVWEDLDMPSGYA YGKTLRTVKTCVGEQFCRFGTQDSMALGIALEKKFEGLNTPHKVKMAVSACPRNCAES GIKDLGVVGIDGGWELYVGGNGGTHLRAGDLLMKVKTNEEVLEYAGAYLQYYRETANY LERTSAWLERVGLSHVQSVLNDPEKRQELNGRMNETLSVHKDPWKDFLEDKQTSKELF ENVVTTS*" gene complement(355764..358181) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" promotor_-10 complement(358206..358225) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(358220) /Source="Nicolas_upshifts" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" promotor_-35 complement(358237..358243) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(358303..360435) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" /EC_number="1.7.99.4" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (catalytic subunit)" /protein_id="NP_388213.2" /db_xref="EnsemblGenomes-Gn:BSU03310" /db_xref="EnsemblGenomes-Tr:CAB12125" /db_xref="GOA:P42434" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="SubtiList:BG11095" /db_xref="UniProtKB/Swiss-Prot:P42434" /translation="MTERLLRYFRDKQQDVQSEKTYDTQCPFCSMQCKMQLVEQTIVT RKKYTAIGIDNPTTQGRLCIKGMNAHQHALNSSRITRPLLKKNGEFMPVSWEEALNHI KDQVTMIQTEHGHDAMAVYGSASITNEEAYLLGKFARVGLQTKYIDYNGRLCMSAAAT AANQTFGADRGLTNPLSDIPHTRVIILAGTNIAECQPTIMPYFEKAKENGAYFIAIDP RETATTKIADLHLKIKPGTDAALANGLVKIIIDEQLINEDFIQSRTNGFEELKQHTDS LDLNDIAEQTSVSLVDIRKAAVKFAKETSGMLFTARGIEQQTDGTAAVKGFLNMVLIT GKIGKPYSGYGAITGQGNGQGAREHGQKADQLPGYRSIENEEHRAHIAKVWGIHQDEL PRKGVSAYEMMEKINDGDIKGLFLMCSNPAVSSPNANLVKKALRRLTFFVAIDLFISE TAKYADVILPASSYLEDEGTMTNVEGRVTLREASRPCPGEAKHDWQIICDLASALGKG RYFSYTSAEDIFNELREASRGGIADYSGISYGRLRREGGIHWPCPESDHPGTGRLFTE SFAHPDQKAALSVIPNEPPVPKEKPTADYPLYLTTGRVMSHYLTGVQTRKSAALAARH FESFMEIHPQTAATYNIEDRVLVKIESPRGSITVRSKLSEQIRKDTVFVPIHWADAQN VNDLIGEALDPACKMPGFKVCAVRIIPI*" gene complement(358303..360435) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" CDS complement(360442..362757) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" /EC_number="1.7.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (electron transfer subunit NasB)" /protein_id="NP_388214.2" /db_xref="EnsemblGenomes-Gn:BSU03320" /db_xref="EnsemblGenomes-Tr:CAB12126" /db_xref="GOA:P42433" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11094" /db_xref="UniProtKB/Swiss-Prot:P42433" /translation="MKKQRLVLAGNGMAGIRCIEEVLKLNRHMFEIVIFGSEPHPNYN RILLSSVLQGEASLDDITLNSKDWYDKHGITLYTGETVIQIDTDQQQVITDRKRTLSY DKLIVATGSSPHILPIPGADKKGVYGFRTIEDCQALMNMAQHFQKAAVIGAGLLGLEA AVGLQHLGMDVSVIHHSAGIMQKQLDQTAARLLQTELEQKGLTFLLEKDTVSISGATK ADRIHFKDGSSLKADLIVMAAGVKPNIELAVSAGIKVNRGIIVNDFMQTSEPNIYAVG ECAEHNGTVYGLVAPLYEQGKALASHICGVPCEEYQGSAPSAALKIAGIDVWSAGKIQ EDERTTSIKIYDEQAGVYKKALFVDDKLAGVILFGDTRDKQRLLDSLLKQRDISIAKK QIIEPETSGPLFESMPSSETICQCNTVTKGAIEDAVHTNSLTTVEEVKHCTKATGSCG GCKPLVEDLLRYMTNSEYTKPASTPSFCSCTDFTEDDIIAELQRRPFTNPAEVMNQLD WKTKNGCSTCVPAIQYYLEMLYPGFVQPEPATEETCILIPQMYGGRTNAEQLRTIANI IEAYSIPDVSITHGQRLKLSGIKPADLPNMKKDLKMPVYTNEHRHALQSIKACTCGQN RSIQQLAAQIERQLEMLPLPAPISISLSCETDCTEAALQDVGAIRTQAGWDIHIGGVR GTHARSGALFCVTENEDSTAGMIKGLIQYYRETAHYLEGVHQWIDRLGIVHIREVLFE EDLRAQLLESLQTDLSLIQNPTVETGAYKKG*" gene complement(360442..362757) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" promotor_no_box complement(362776..362876) /Source="Nicolas_upshift_promotors" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(362816) /Source="Nicolas_upshifts" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" promotor_-35 362859..362866 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 362880..362899 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 362892 /Source="Nicolas_upshifts" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" CDS 362937..364142 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7868621, 12823818, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative nitrate transporter" /protein_id="NP_388215.2" /db_xref="EnsemblGenomes-Gn:BSU03330" /db_xref="EnsemblGenomes-Tr:CAB12127" /db_xref="GOA:P42432" /db_xref="InterPro:IPR004737" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11093" /db_xref="UniProtKB/Swiss-Prot:P42432" /translation="MKLSELKTSGHPLTLLCSFLYFDVSFMIWVMLGALGVYISQDFG LSPFEKGLVVAVPILSGSVFRIILGILTDRIGPKKTAVIGMLVTMIPLLWGTFGGRSL TELYAIGILLGVAGASFAVALPMASRWYPPHLQGLAMGIAGAGNSGTLFATLFGPRLA EQFGWHIVMGIALIPLLIVFILFVSMAKDSPAQPSPQPLKSYLHVFGQKETWFFCLLY SVTFGGFVGLSSFLSIFFVDQYQLSKIHAGDFVTLCVAAGSFFRPVGGLISDRVGGTK VLSVLFVIVALCMAGVSSLPSLSMVIVLLFVGMMGLGMGNGAVFQLVPQRFRKEIGMV TGIVGAAGGIGGFFLPNILGSLKQMTGTYAIGFITFSCIALLAFALVLAAGYYWRKSW SAESSPADV*" gene 362937..364142 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" downshifts 364127 /Source="Nicolas_upshifts" /id="D146" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.02479" /MaxDrop="3.6823" /score="39.2612286" /energy="-11.9" /TU="NA" /idTUdmin="U253" /TUdmin=0 /isTUend="TRUE" promotor_-35 364186..364192 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-35" promotor_-10 364207..364226 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-10" upshifts 364215 /Source="Nicolas_upshifts" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" CDS 364259..365173 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12426338, 17032654, 19767425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12426338, 17032654, 19767425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_388216.2" /db_xref="EnsemblGenomes-Gn:BSU03340" /db_xref="EnsemblGenomes-Tr:CAB12128" /db_xref="GOA:P94398" /db_xref="InterPro:IPR003801" /db_xref="InterPro:IPR022838" /db_xref="SubtiList:BG12019" /db_xref="UniProtKB/Swiss-Prot:P94398" /translation="MNQHTLLPKKTERLQYFGSVSPIKGEKPVEKEKMKDLQNIRKDY FFDIQHVGVANVSHPVTITSAMMPAEQTTAANFTMTCNLPRNQKGINMSRLTELLQVY HQNGWILSFSSLQQFTKELAENMDTSSATVEVRFPWFFERKSPKLEKAGLMHADIFMS VTYRKDQPFKQRAGISAKVTTLCPCSKEISEYSAHNQRGTVSIWADIHPAASLPSDVK ADLLHAAESNASARLHPVLKRPDEKAVTETAYENPRFVEDLARLIAADLFELEWVSAF EIECRNEESIHLHDAYAKLCFSKEVDKI*" gene 364259..365173 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" CDS 365170..365754 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12426338, 20013255; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative Zn(2+)-dependent division lipoprotein (schizosome)" /protein_id="NP_388217.2" /db_xref="EnsemblGenomes-Gn:BSU03350" /db_xref="EnsemblGenomes-Tr:CAB12129" /db_xref="GOA:C0SP99" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG12020" /db_xref="UniProtKB/Swiss-Prot:C0SP99" /translation="MKLSLFIIAVLMPVILLSACSDHAEEHASINTKKTVENITDVRK TAKTSIDWTKPSGGEYPDIKQKHVWIDVNVKEQKAYIKEGSNTIYTMMISSGLDQTKD DATPKGTFYVEPERGEWFFSEGYQEGAEYWVSWKNHGEFLFHSVPMTKDQKVIKTEAE KLGTKASHGCIRLTIPDAKWVYENIPEHTKVVIS*" gene 365170..365754 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" promotor_-35 365765..365772 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 365786..365805 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 365796 /Source="Nicolas_upshifts" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" CDS 365850..366035 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097674.1" /db_xref="EnsemblGenomes-Gn:BSU03359" /db_xref="EnsemblGenomes-Tr:CAX52544" /db_xref="UniProtKB/Swiss-Prot:C0H3U7" /translation="MKSGKASIKDLAVGKGKDLRWGKGLNAVGVFTDLEIGRQREMSA KSCSTPLYIRRSIQFKS*" gene 365850..366035 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" CDS 366063..367256 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249; Product type t: transporter" /codon_start=1 /transl_table=11 /product="zinc metallochaperone with NTPase activity" /protein_id="NP_388218.1" /db_xref="EnsemblGenomes-Gn:BSU03360" /db_xref="EnsemblGenomes-Tr:CAB12130" /db_xref="GOA:P94400" /db_xref="InterPro:IPR003495" /db_xref="InterPro:IPR011629" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036627" /db_xref="SubtiList:BG12021" /db_xref="UniProtKB/Swiss-Prot:P94400" /translation="MKKIPVTVLSGYLGAGKTTLLNSILQNREGLKIAVIVNDMSEVN IDAGLVKQEGGLSRTDEKLVEMSNGCICCTLREDLLIEVEKLAKDGRFDYIVIESTGI SEPIPVAQTFSYIDEEMGIDLTKFCQLDTMVTVVDANRFWHDYQSGESLLDRKEALGE KDEREIADLLIDQIEFCDVLILNKCDLVSEQELEQLENVLRKLQPRARFIRSVKGNVK PQEILHTGLFNFEEASGSAGWIQELTAGHAEHTPETEEYGISSFVYKRRLPFHSTRFY RWLDQMPKNVVRAKGIVWCASHNNLALLMSQAGPSVTIEPVSYWVAALPKLEQEQVKQ QEPEILEEWDPEFGDRLTQLVFIGTDLDEETITKELDQCLLTEYEFDSDWSLFEDPFK WKLNQ*" gene 366063..367256 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" downshifts 367248 /Source="Nicolas_upshifts" /id="D147" /incds=0 /nref=26 /ntot=45 /MaxReadThrough="5.12378" /MaxDrop="5.8275" /score="15.6427627" /energy="-9.2" /TU="U255" /idTUdmin="U255" /TUdmin="-792" /isTUend="FALSE" S_feature 367293..368962 /Source="Nicolas_S_feature" /locus_tag="new_367293_368962" /HighExp="Etha, B60, Cold, Heat, B36, C30, BMM, S6, C90, S2" /AntisenseName="yckB" /AntisenseCor="-0.170121935628575" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S121" CDS complement(367305..367985) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aminoacid ABC transporter (permease subunit)" /protein_id="NP_388219.1" /db_xref="EnsemblGenomes-Gn:BSU03370" /db_xref="EnsemblGenomes-Tr:CAB12131" /db_xref="GOA:P42399" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11177" /db_xref="UniProtKB/Swiss-Prot:P42399" /translation="MINSIQWEYIFNTKLAIESFPYVIKGIGYTLLISFVSMFAGTVI GLFISLARMSKLALLRWPAKLYISFMRGVPILVILFILYFGFPYIGIEFSAVTAALIG FSLNSAAYIAEINRSAISSVEKGQWEAASSLGLSYWQTMRGIILPQSIRIALPPLANV LLDLIKASSLAAMITVPELLQHAKIIGGREFDYMTMYILTALIYWAICSIAAVFQNIL EKKYAHYV*" gene complement(367305..367985) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" downshifts complement(367311) /Source="Nicolas_upshifts" /id="D148" /incds=0 /nref=101 /ntot=231 /MaxReadThrough="0.41655" /MaxDrop="6.18136" /score="40.1548023" /energy="-12.6" /TU="NA" /idTUdmin="U256" /TUdmin="-9" /isTUend="TRUE" CDS complement(367995..368858) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23038252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="amino acid ABC transporter (binding lipoprotein subunit)" /protein_id="NP_388220.1" /db_xref="EnsemblGenomes-Gn:BSU03380" /db_xref="EnsemblGenomes-Tr:CAB12132" /db_xref="GOA:P42400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="PDB:2IEE" /db_xref="SubtiList:BG11178" /db_xref="UniProtKB/Swiss-Prot:P42400" /translation="MKSFMHSKAVIFSFTMAFFLILAACSGKNEADSKDTGWEQIKDK GKIVVATSGTLYPTSYHDTDSGSDKLTGYEVEVVREAAKRLGLKVEFKEMGIDGMLTA VNSGQVDAAANDIDVTKDREEKFAFSTPYKYSYGTAIVRKDDLSGIKTLKDLKGKKAA GAATTVYMEVARKYGAKEVIYDNATNEQYLKDVANGRTDVILNDYYLQTLALAAFPDL NITIHPDIKYMPNKQALVMKKSNAALQKKMNEALKEMSKDGSLTKLSKQFFNKADVSK KIDADVQDVDL*" gene complement(367995..368858) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" promotor_-10 complement(368880..368899) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(368892) /Source="Nicolas_upshifts" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" S_feature complement(368894..371728) /Source="Nicolas_S_feature" /locus_tag="new_368894_371728_c" /HighExp="GM 150, T-4.40H, G/S, Pyr, S2, C30, T-5.40H, C90, T-3.40H, T0.30H" /AntisenseName="bglC" /AntisenseCor="-0.37749573319969598" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, Sig-" /TUshortPSig="0.248, 0.994, 0.0879" /TUlongSig="SigD" /TUlongPSig=1 /label="S122" promotor_-35 complement(368914..368921) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 368931..368937 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 368952..368970 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 368964..369186 /Source="Nicolas_S_feature" /locus_tag="new_368964_369186" /HighExp="Etha, Salt, B60, Sw, B36, Gly, Heat, S6, Cold, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99896700000000005" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S123" upshifts 368964 /Source="Nicolas_upshifts" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" CDS 369020..369217 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513942.1" /translation="MSKDECQTYQGNACESEGCSRPVTHLCQYRKKWSRGMKPIFRIN LSLADAPKAYDIFDEKENGNI*" gene 369020..369217 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" promotor_-35 369155..369160 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 369176..369194 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 369188 /Source="Nicolas_upshifts" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" CDS 369236..369691 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral membrane protein of unknown function" /protein_id="NP_388221.1" /db_xref="EnsemblGenomes-Gn:BSU03390" /db_xref="EnsemblGenomes-Tr:CAB12133" /db_xref="GOA:P42401" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11179" /db_xref="UniProtKB/Swiss-Prot:P42401" /translation="MNIYKPAGFWIRLGAALLDYIIVSVPLLLIYWLITGKDPNDSMF ISLVVLLYSILLPMFWRGYLIGKRICGIRIVKKDGSQVSLLTMFLRVIVAGLVYCITF GLGLIASLILIAVREDKRTLHDLIAGTYVTYATPGEEELNADEEIRKSE*" gene 369236..369691 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" downshifts 369666 /Source="Nicolas_upshifts" /id="D149" /incds=0 /nref=40 /ntot=193 /MaxReadThrough="1.14817" /MaxDrop="5.48303" /score="23.1539807" /energy="-9.8" /TU="NA" /idTUdmin="U257" /TUdmin="-2" /isTUend="TRUE" promotor_-35 369714..369720 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 369727 /Source="Nicolas_upshifts" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" promotor_-10 369734..369745 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 369773..370105 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388222.1" /db_xref="EnsemblGenomes-Gn:BSU03400" /db_xref="EnsemblGenomes-Tr:CAB12134" /db_xref="InterPro:IPR024485" /db_xref="SubtiList:BG11180" /db_xref="UniProtKB/Swiss-Prot:P42402" /translation="MKRITINIITMFIAAAVISLTGTAEAAEKQQQSPANVTLTDQQK KEIEQLEAEILKKRKDVISKYVQYGILPKERGEHIKNHLDKHFEMMKQNGFVPKHHPH PHKFEKRH*" gene 369773..370105 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" downshifts 370086 /Source="Nicolas_upshifts" /id="D150" /incds=0 /nref=20 /ntot=44 /MaxReadThrough="2.48743" /MaxDrop="4.3022" /score="-1.40416926" /energy="-11.8" /TU="NA" /idTUdmin="U259" /TUdmin=0 /isTUend="TRUE" promotor_-35 370191..370198 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 370214..370233 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 370218 /Source="Nicolas_upshifts" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" CDS 370259..371692 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916, 18069788" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916, 18069788; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_388223.1" /db_xref="EnsemblGenomes-Gn:BSU03410" /db_xref="EnsemblGenomes-Tr:CAB12135" /db_xref="GOA:P42403" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11181" /db_xref="UniProtKB/Swiss-Prot:P42403" /translation="MIHQHPESFPKHFLWGSASAAYQIEGAWNEDGKGPSVWDVFTKI PGKTFKGTNGEIAVDHYHRFKEDVALMAEMGLKAYRFSVSWPRVFPKGKGEINEAGLA FYDSLIDELLSHHIEPVLTLYHWDLPQALMDEYGGFESRNIIEDFNHYCITLYKRFGD RVKYWVTLNEQNYNFNHGFITAMHPPGVKDRKRFYEANHIAFLANAKAIESFREYVPE GKIGPSFAYSPAYPLSSHPEDILAFENAEEFTNNWWLDMYCWGTYPQIPFRCLEKQGW APTIEAGDMDLLAKGKPDFVGVNYYQTITYERNPLDGVSEGKMNTTGQKGTNQETGIP GVFKTKKNPHLTTSNWDWTIDPIGLRIGLRRITSRYQLPVFITENGLGEFDKVEDGTV QDDYRIDYLRSHLEQCRQAISDGVDLIGYCSWSFTDLLSWLNGYQKRYGFVYVNRDEE STSDLKRLKKKSFYWYQDVIKTNGESL*" gene 370259..371692 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" downshifts 371670 /Source="Nicolas_upshifts" /id="D151" /incds=0 /nref=12 /ntot=61 /MaxReadThrough="1.51167" /MaxDrop="4.6748" /score="18.0928088" /energy="-15.9" /TU="NA" /idTUdmin="U260" /TUdmin=0 /isTUend="TRUE" CDS complement(371729..372127) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11359569, 11814663, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11359569, 11814663, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the DNA degrading activity of NucA (competence)" /protein_id="NP_388224.1" /db_xref="EnsemblGenomes-Gn:BSU03420" /db_xref="EnsemblGenomes-Tr:CAB12136" /db_xref="GOA:P12669" /db_xref="InterPro:IPR020354" /db_xref="PDB:4MQD" /db_xref="SubtiList:BG10839" /db_xref="UniProtKB/Swiss-Prot:P12669" /translation="MIKSWKPQELSISYHQFTVFQKDSTPPVMDWTDEAIEKGYAAAD GAISFEAQRNTKAFILFRLNSSETVNSYEKKVTVPFHVTENGIHIESIMSKRLSFDLP KGDYQLTCWTVPAEMSDLHADTYIIDAVSV*" gene complement(371729..372127) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" promotor_no_box complement(372124..372224) /Source="Nicolas_upshift_promotors" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" /label="promotor_no_box" CDS complement(372154..372603) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2841296, 7746143, 11359569, 11814663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2841296, 7746143, 11359569, 11814663; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease" /protein_id="NP_388225.3" /db_xref="EnsemblGenomes-Gn:BSU03430" /db_xref="EnsemblGenomes-Tr:CAB12137" /db_xref="GOA:P12667" /db_xref="InterPro:IPR029476" /db_xref="SubtiList:BG10838" /db_xref="UniProtKB/Swiss-Prot:P12667" /translation="MNITTDIIKTILLVIVIIAAAAVGLIKGDFFSADQKTSQTKEYD ETMAFPSDRYPETAKHIKDAINEGHSEVCTIDRDGAEERREQSLKDVPSKKGYDRDEW PMAMCKEGGEGASVEYISPADNRGAGSWVGHRLTDYPDGTKVLFTIQ*" gene complement(372154..372603) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" upshifts complement(372164) /Source="Nicolas_upshifts" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" promotor_-10 complement(372618..372637) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(372626) /Source="Nicolas_upshifts" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" S_feature complement(372628..372770) /Source="Nicolas_S_feature" /locus_tag="new_372628_372770_c" /HighExp="C30, Diami, M40t45, Cold, Lbstat, T0.30H, M0t90, dia15, C90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD" /TUshortPSig="0.0879, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S124" promotor_-35 complement(372651..372658) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(372771..374492) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7704255, 7921238, 15187186, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704255, 7921238, 15187186, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein (plant colonization)" /protein_id="NP_388226.2" /db_xref="EnsemblGenomes-Gn:BSU03440" /db_xref="EnsemblGenomes-Tr:CAB12138" /db_xref="GOA:P39209" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="SubtiList:BG10790" /db_xref="UniProtKB/Swiss-Prot:P39209" /translation="MLIKRFKMKLGTKILCLVFVVILLFSASVGTVMLKEITESMKQM ATEKAKGDLALSSTYIDDVMSGDWQVKNNKLYKGQTQINGNEDIVDLLGEKTGDTITI FQGDTRVATNVMKNGERAVGTQASSEVIAAVLKKGKRFYGQADVAGSSYQTAYMPLKD QNGNIIGMLYTGANQSILASLTQSLFTQFAIVLVIVIMVSVILVLVFTRKINKRLNAL KSAFESAGNGDMTIEVSDKTGDELSELSVYYNKMRMKLNDTIQTVQQSALQLASASQQ LSAGAEETNQASEKITEAVQQIANGAQDQITRIENSESSLKQASADIRDISANTAAIA DKGQLAQSKADIGQKEIANVQAQMDAIHQSIQKSGEIIHQLDGRSKQIEQILSVITQI ADQTNLLALNAAIEAARAGEQGKGFAVVADEVRKLAEESQQSAGQISKLIIEIQKDMN RSARSVEHVKTEAAEGVTMIQRTRDAFKEIAAATGEISAEISDLSASVTNISASAHQI NDSFAANTADIKESTKNTRQAAALTEEQFAAMEEITAASETLSQLAEELTGIISQFKM INQAENG*" gene complement(372771..374492) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" promotor_-35 372783..372790 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 372801..375944 /Source="Nicolas_S_feature" /locus_tag="new_372801_375944" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, T4.0H, T0.0H, T-0.40H" /AntisenseName="tlpC" /AntisenseCor="-0.40398083053643302" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S125" upshifts 372801 /Source="Nicolas_upshifts" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" promotor_-10 372805..372824 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box complement(372806..372906) /Source="Nicolas_upshift_promotors" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" /label="promotor_no_box" upshifts complement(372846) /Source="Nicolas_upshifts" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" promotor_-10 complement(374516..374534) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-10" upshifts complement(374531) /Source="Nicolas_upshifts" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" promotor_-35 complement(374548..374555) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-35" CDS complement(374603..375160) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" /EC_number="5.3.1.27" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-3-hexuloisomerase (PHI)" /protein_id="NP_388227.1" /db_xref="EnsemblGenomes-Gn:BSU03450" /db_xref="EnsemblGenomes-Tr:CAB12139" /db_xref="GOA:P42404" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR017552" /db_xref="PDB:1M3S" /db_xref="PDB:1VIV" /db_xref="SubtiList:BG11182" /db_xref="UniProtKB/Swiss-Prot:P42404" /translation="MKTTEYVAEILNELHNSAAYISNEEADQLADHILSSHQIFTAGA GRSGLMAKSFAMRLMHMGFNAHIVGEILTPPLAEGDLVIIGSGSGETKSLIHTAAKAK SLHGIVAALTINPESSIGKQADLIIRMPGSPKDQSNGSYKTIQPMGSLFEQTLLLFYD AVILKLMEKKGLDSETMFTHHANLE*" gene complement(374603..375160) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" downshifts complement(374606) /Source="Nicolas_upshifts" /id="D152" /incds=0 /nref=51 /ntot=130 /MaxReadThrough="1.98332" /MaxDrop="6.56052" /score="42.3682356" /energy="-15.4" /TU="NA" /idTUdmin="U266" /TUdmin=0 /isTUend="TRUE" CDS complement(375166..375798) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" /EC_number="4.1.2.43" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hexulose-6-phosphate synthase (HPS)" /protein_id="NP_388228.1" /db_xref="EnsemblGenomes-Gn:BSU03460" /db_xref="EnsemblGenomes-Tr:CAB12140" /db_xref="GOA:P42405" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017553" /db_xref="SubtiList:BG11183" /db_xref="UniProtKB/Swiss-Prot:P42405" /translation="MELQLALDLVNIPEAIELVKEVEQYIDVVEIGTPVVINEGLRAV KEIKEAFPQLKVLADLKIMDAGGYEIMKASEAGADIITVLGATDDATIKGAVEEAKKQ KKKILVDMINVKDIESRAKEIDALGVDYICVHTGYDLQAEGKNSFEELTTIKNTVKNA KTAIAGGIKLDTLPEVIQQKPDLVIVGGGITSAADKAETASKMKQLIVQG*" gene complement(375166..375798) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" promotor_-10 complement(375824..375843) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(375839) /Source="Nicolas_upshifts" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" promotor_-35 complement(375858..375861) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 375922..375925 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 375940..375959 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 375946 /Source="Nicolas_upshifts" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" CDS 376032..376394 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15978081, 26973631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15978081, 26973631; Product type r: regulator" /codon_start=1 /transl_table=11 /product="positive regulator of hxlAB expression (formaldehyde sensing)" /protein_id="NP_388229.2" /db_xref="EnsemblGenomes-Gn:BSU03470" /db_xref="EnsemblGenomes-Tr:CAB12141" /db_xref="GOA:P42406" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11184" /db_xref="UniProtKB/Swiss-Prot:P42406" /translation="MSRMDDKRFNCEKELTLAVIGGKWKMLILWHLGKEGTKRFNELK TLIPDITQKILVNQLRELEQDMIVHREVYPVVPPKVEYSLTPHGESLMPILEAMYEWG KGYMELIDIDKNVMKESL*" gene 376032..376394 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" downshifts 376378 /Source="Nicolas_upshifts" /id="D153" /incds=0 /nref=14 /ntot=154 /MaxReadThrough="3.13609" /MaxDrop="3.66949" /score="20.4643411" /energy="-9.6" /TU="U267" /idTUdmin="U263" /TUdmin="-2" /isTUend="TRUE" promotor_-35 376641..376644 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 376659..376678 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 376667..376967 /Source="Nicolas_S_feature" /locus_tag="new_376667_376967" /HighExp="HiOs, T-1.10H, T5.0H, T4.0H, T-1.40H, S2, M9-stat, T3.30H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.20585600000000001" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S126" upshifts 376667 /Source="Nicolas_upshifts" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" CDS 376968..387731 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388230.2" /db_xref="EnsemblGenomes-Gn:BSU03480" /db_xref="EnsemblGenomes-Tr:CAB12142" /db_xref="GOA:P27206" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR013321" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10168" /db_xref="UniProtKB/Swiss-Prot:P27206" /translation="MEITFYPLTDAQKRIWYTEKFYPHTSISNLAGIGKLVSADAIDY VLVEQAIQEFIRRNDAMRLRLRLDENGEPVQYISEYRPVDIKHTDTTEDPNAIEFISQ WSREETKKPLPLYDCDLFRFSLFTIKENEVWFYANVHHVISDGISMNILGNAIMHIYL ELASGSETKEGISHSFIDHVLSEQEYAQSKRFEKDKAFWNKQFESVPELVSLKRNASA GGSLDAERFSKDVPEALHQQILSFCEANKVSVLSVFQSLLAAYLYRVSGQNDVVTGTF MGNRTNAKEKQMLGMFVSTVPLRTNIDGGQAFSEFVKDRMKDLMKTLRHQKYPYNLLI NDLRETKSSLTKLFTVSLEYQVMQWQKEEDLAFLTEPIFSGSGLNDVSIHVKDRWDTG KLTIDFDYRTDLFSREEINMICERMITMLENALTHPEHTIDELTLISDAEKEKLLARA GGKSVSYRKDMTIPELFQEKAELLSDHPAVVFEDRTLSYRTLHEQSARIANVLKQKGV GPDSPVAVLIERSERMITAIMGILKAGGAYVPIDPGFPAERIQYILEDCGADFILTES KVAAPEADAELIDLDQAIEEGAEESLNADVNARNLAYIIYTSGTTGRPKGVMIEHRQV HHLVESLQQTIYQSGSQTLRMALLAPFHFDASVKQIFASLLLGQTLYIVPKKTVTNGA ALTAYYRKNSIEATDGTPAHLQMLAAAGDFEGLKLKHMLIGGEGLSSVVADKLLKLFK EAGTAPRLTNVYGPTETCVDASVHPVIPENAVQSAYVPIGKALGNNRLYILDQKGRLQ PEGVAGELYIAGDGVGRGYLHLPELTEEKFLQDPFVPGDRMYRTGDVVRWLPDGTIEY LGREDDQVKVRGYRIELGEIEAVIQQAPDVAKAVVLARPDEQGNLEVCAYVVQKPGSE FAPAGLREHAARQLPDYMVPAYFTEVTEIPLTPSGKVDRRKLFALEVKAVSGTAYTAP RNETEKAIAAIWQDVLNVEKAGIFDNFFETGGHSLKAMTLLTKIHKETGIEIPLQFLF EHPTITALAEEADHRESKAFAVIEPAEKQEHYPLSLAQQRTYIVSQFEDAGVGYNMPA AAILEGPLDIQKLERAFQGLIRRHESLRTSFVLENSTPRQKIHDSVDFNIEMIERGGR SDEAIMASFVRTFDLAKAPLFRIGLLGLEENRHMLLFDMHHLISDGVSIGIMLEELAR IYKGEQLPDLRLQYKDYAVWQSRQAAEGYKKDQAYWKEVFAGELPVLQLLSDYPRPPV QSFEGDRVSIKLDAGVKDRLNRLAEQNGATLYMVMLSAYYTLLSKYTGQDDIIVGTPS AGRNHSDTEGIIGMFVNTLAIRSEVKQNETFTQLISRVRKRVLDAFSHQDYPFEWLVE DLNIPRDVSRHPLFDTMFSLQNATEGIPAVGDLSLSVQETNFKIAKFDLTVQARETDE GIEIDVDYSTKLFKQSTADRLLTHFARLLEDAAADPEKPISEYKLLSEEEAASQIQQF NPGRTPYPKDKTIVQLFEEQAANTPDHTALQYEGESLTYRELNERANRLARGILSLGA GEGRTAAVLCERSMDMIVSILAVLKSGSAYVPIDPEHPIQRMQHFFRDSGAKVLLTQR KLKALAEEAEFKGVIVLADEEESYHADARNLALPLDSAAMANLTYTSGTTGTPKGNIV THANILRTVKETNYLSITEQDTILGLSNYVFDAFMFDMFGSLLNGAKLVLIPKETVLD MARLSRVIERENISILMITTALFHLLVDLNPACLSTLRKIMFGGERASVEHVRKALQT VGKGKLLHMYGPSESTVFATYHPVDELEEHTLSVPIGKPVSNTEVYILDRTGHVQPAG IAGELCVSGEGLVKGYYNRPELTEEKFVPHPFTSGERMYKTGDLARWLPNGDIEFIGR IDHQVKIRGQRIELGEIEHQLQTHDRVQESVVLAVDQGAGDKLLCAYYVGEGDISSQE MREHAAKDLPAYMVPAVFIQMDELPLTGNGKIDRRALPIPDANVSRGVSYVAPRNGTE QKVADIWAQVLQAEQVGAYDHFFDIGGHSLAGMKMLALVHQELGVELSLKDLFQSPTV EGLAQVIASAEKGTAASISPAEKQDTYPVSSPQKRMYVLQQLEDAQTSYNMPAVLRLT GELDVERLNSVMQQLMQRHEALRTTFEIKDGETVQRIWEEAECEIAYFEAPEEETERI VSEFIKPFKIDQLPLFRIGLIKHSDTEHVLLFDMHHIISDGASVGVLIEELSKLYDGE TLEPLRIQYKDYAVWQQQFIQSELYKKQEEHWLKELDGELPVLTLPTDYSRPAVQTFE GDRIAFSLEAGKADALRRLAKETDSTLYMVLLASYSAFLSKISGQDDIIVGSPVAGRS QADVSRVIGMFVNTLALRTYPKGEKTFADYLNEVKETALSAFDAQDYPLEDLIGNVQV QRDTSRNPLFDAVFSMQNANIKDLTMKGIQLEPHPFERKTAKFDLTLTADETDGGLTF VLEYNTALFKQETIERWKQYWMELLDAVTGNPNQPLSSLSLVTETEKQALLEAWKGKA LPVPTDKTVHQLFEETAQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDD RVGVLTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISV PDSYTGDVILLDGSRTILSLPLDENDEENPETAVTAENLAYMIYTSGTTGQPKGVMVE HHALVNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIEEAIRLD IVRLNDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNY GPTENTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLA RGYLNREDETAKRFVADPFVPGERMYRTGDLVKWTGGGIEYIGRIDQQVKVRGYRIEL SEIEVQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPESADIEALKSALKETLPDYMIP AFWVTLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEV GVTDNFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQ GPVEGEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDAL RMVYREGQEDVIQYNRGLEAASAQLEVIQIEGQAADYEDRIEREAERLQSSIDLQEGG LLKAGLFQAEDGDHLLLAIHHLVVDGVSWRILLEDFAAVYTQLEQGNEPVLPQKTHSF AEYAERLQDFANSKAFLKEKEYWRQLEEQAVAAKLPKDRESGDQRMKHTKTIEFSLTA EETEQLTTKVHEAYHTEMNDILLTAFGLAMKEWTGQDRVSVHLEGHGREEIIEDLTIS RTVGWFTSMYPMVLDMKHADDLGYQLKQMKEDIRHVPNKGVGYGILRYLTAPEHKEDV AFSIQPDVSFNYLGQFDEMSDAGLFTRSELPSGQSLSPETEKPNALDVVGYIENGKLT MSLAYHSLEFHEKTVQTFSDSFKAHLLRIIEHCLSQDGTELTPSDLGDDDLTLDELDK LMEIF*" gene 376968..387731 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" CDS 387744..398495 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388231.2" /db_xref="EnsemblGenomes-Gn:BSU03490" /db_xref="EnsemblGenomes-Tr:CAB12143" /db_xref="GOA:Q04747" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10169" /db_xref="UniProtKB/Swiss-Prot:Q04747" /translation="MSKKSIQKVYALTPMQEGMLYHAMLDPHSSSYFTQLELGIHGAF DLEIFEKSVNELIRSYDILRTVFVHQQLQKPRQVVLAERKTKVHYEDISHADENRQKE HIERYKQDVQRQGFNLAKDILFKVAVFRLAADQLYLVWSNHHIMMDGWSMGVLMKSLF QNYEALRAGRTPANGQGKPYSDYIKWLGKQDNEEAESYWSERLAGFEQPSVLPGRLPV KKDEYVNKEYSFTWDETLVARIQQTANLHQVTGPNLFQAVWGIVLSKYNFTDDVIFGT VVSGRPSEINGIETMAGLFINTIPVRVKVERDAAFADIFTAVQQHAVEAERYDYVPLY EIQKRSALDGNLLNHLVAFENYPLDQELENGSMEDRLGFSIKVESAFEQTSFDFNLIV YPGKTWTVKIKYNGAAFDSAFIERTAEHLTRMMEAAVDQPAAFVREYGLVGDEEQRQI VEVFNSTKAELPEGMAVHQVFEEQAKRTPASTAVVYEGTKLTYRELNAAANRLARKLV EHGLQKGETAAIMNDRSVETVVGMLAVLKAGAAYVPLDPALPGDRLRFMAEDSSVRMV LIGNSYTGQAHQLQVPVLTLDIGFEESEAADNLNLPSAPSDLAYIMYTSGSTGKPKGV MIEHKSILRLVKNAGYVPVTEEDRMAQTGAVSFDAGTFEVFGALLNGAALYPVKKETL LDAKQFAAFLREQSITTMWLTSPLFNQLAAKDAGMFGTLRHLIIGGDALVPHIVSKVK QASPSLSLWNGYGPTENTTFSTSFLIDREYGGSIPIGKPIGNSTAYIMDEQQCLQPIG APGELCVGGIGVARGYVNLPELTEKQFLEDPFRPGERIYRTGDLARWLPDGNIEFLGR IDNQVKVRGFRIELGEIETKLNMAEHVTEAAVIIRKNKADENEICAYFTADREVAVSE LRKTLSQSLPDYMVPAHLIQMDSLPLTPNGKINKKELPAPQSEAVQPEYAAPKTESEK KLAEIWEGILGVKAGVTDNFFMIGGHSLKAMMMTAKIQEHFHKEVPIKVLFEKPTIQE LALYLEENESKEEQTFEPIRQASYQQHYPVSPAQRRMYILNQLGQANTSYNVPAVLLL EGEVDKDRLENAIQQLINRHEILRTSFDMIDGEVVQTVHKNISFQLEAAKGREEDAEE IIKAFVQPFELNRAPLVRSKLVQLEEKRHLLLIDMHHIITDGSSTGILIGDLAKIYQG ADLELPQIHYKDYAVWHKEQTNYQKDEEYWLDVFKGELPILDLPADFERPAERSFAGE RVMFGLDKQITAQIKSLMAETDTTMYMFLLAAFNVLLSKYASQDDIIVGSPTAGRTHP DLQGVPGMFVNTVALRTAPAGDKTFAQFLEEVKTASLQAFEHQSYPLEELIEKLPLTR DTSRSPLFSVMFNMQNMEIPSLRLGDLKISSYSMLHHVAKFDLSLEAVEREEDIGLSF DYATALFKDETIRRWSRHFVNIIKAAAANPNVRLSDVDLLSSAETAALLEERHMTQIT EATFAALFEKQAQQTPDHSAVKAGGNLLTYRELDEQANQLAHHLRAQGAGNEDIVAIV MDRSAEVMVSILGVMKAGAAFLPIDPDTPEERIRYSLEDSGAKFAVVNERNMTAIGQY EGIIVSLDDGKWRNESKERPSSISGSRNLAYVIYTSGTTGKPKGVQIEHRNLTNYVSW FSEEAGLTENDKTVLLSSYAFDLGYTSMFPVLLGGGELHIVQKETYTAPDEIAHYIKE HGITYIKLTPSLFHTIVNTASFAKDANFESLRLIVLGGEKIIPTDVIAFRKMYGHTEF INHYGPTEATIGAIAGRVDLYEPDAFAKRPTIGRPIANAGALVLNEALKLVPPGASGQ LYITGQGLARGYLNRPQLTAERFVENPYSPGSLMYKTGDVVRRLSDGTLAFIGRADDQ VKIRGYRIEPKEIETVMLSLSGIQEAVVLAVSEGGLQELCAYYTSDQDIEKAELRYQL SLTLPSHMIPAFFVQVDAIPLTANGKTDRNALPKPNAAQSGGKALAAPETALEESLCR IWQKTLGIEAIGIDDNFFDLGGHSLKGMMLIANIQAELEKSVPLKALFEQPTVRQLAA YMEASAVSGGHQVLKPADKQDMYPLSSAQKRMYVLNQLDRQTISYNMPSVLLMEGELD ISRLRDSLNQLVNRHESLRTSFMEANGEPVQRIIEKAEVDLHVFEAKEDEADQKIKEF IRPFDLNDAPLIRAALLRIEAKKHLLLLDMHHIIADGVSRGIFVKELALLYKGEQLPE PTLHYKDFAVWQNEAEQKERMKEHEAYWMSVLSGELPELDLPLDYARPPVQSFKGDTI RFRTGSETAKAVEKLLAETGTTLHMVLHAVFHVFLSKISGQRDIVIGSVTAGRTNADV QDMPGMFVNTLALRMEAKEQQTFAELLELAKQTNLSALEHQEYPFEDLVNQLDLPRDM SRNPLFNVMVTTENPDKEQLTLQNLSISPYEAHQGTSKFDLTLGGFTDENGIGLQLEY ATDLFAKETAEKWSEYVLRLLKAVADNPNQPLSSLLLVTETEKQALLEAWKGKALPVP TDKTVHQLFEETVQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDDRVGV LTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISVPDSY TGDVILLDGSRTILSLPLDENDEGNPETAVTAENLAYMIYTSGTTGQPKGVMVEHHAL VNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIDEAIRLDIVRL NDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNYGPTE NTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLARGYL NREDETAKRFVADPFVPGERMYRTGDLVKWVNGGIEYIGRIDQQVKVRGYRIELSEIE VQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPETADIEALKSTLKETLPDYMIPAFWV TLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEVGVTD NFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQGPVE GEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDALRMVY REENGDIVQVYKPIGESKVSFEIVDLYGSDEEMLRSQIKLLANKLQSSLDLRNGPLLK AEQYRTEAGDHLLIAVHHLVVDGVSWRILLEDFASGYMQAEKEESLVFPQKTNSFKDW AEELAAFSQSAHLLQQAEYWSQIAAEQVSPLPKDCETEQRIVKDTSSVLCELTAEDTK HLLTDVHQPYGTEINDILLSALGLTMKEWTKGAKIGINLEGHGREDIIPNVNISRTVG WFTAQYPVVLDISDADASAVIKTVKENLRRIPDKGVGYGILRYFTETAETKGFTPEIS FNYLGQFDSEVKTDFFEPSAFDMGRQVSGESEALYALSFSGMIRNGRFVLSCSYNEKE FERATVEEQMERFKENLLMLIRHCTEKEDKEFTPSDFSAEDLEMDEMGDIFDMLEENL K*" gene 387744..398495 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" CDS 390880..391020 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10361283, 16554821, 8752331, 9696775, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 16554821, 8752331, 9696775, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of genetic competence" /protein_id="NP_388232.1" /db_xref="EnsemblGenomes-Gn:BSU03500" /db_xref="EnsemblGenomes-Tr:CAB12144" /db_xref="GOA:P80355" /db_xref="InterPro:IPR035139" /db_xref="SubtiList:BG11045" /db_xref="UniProtKB/Swiss-Prot:P80355" /translation="MNRSGKHLISSIILYPRPSGECISSISLDKQTQATTSPLYFCWR EK*" gene 390880..391020 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" CDS 398532..402359 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388233.2" /db_xref="EnsemblGenomes-Gn:BSU03510" /db_xref="EnsemblGenomes-Tr:CAB12145" /db_xref="GOA:Q08787" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="PDB:1JMK" /db_xref="PDB:2VSQ" /db_xref="SubtiList:BG10170" /db_xref="UniProtKB/Swiss-Prot:Q08787" /translation="MSQFSKDQVQDMYYLSPMQEGMLFHAILNPGQSFYLEQITMKVK GSLNIKCLEESMNVIMDRYDVFRTVFIHEKVKRPVQVVLKKRQFHIEEIDLTHLTGSE QTAKINEYKEQDKIRGFDLTRDIPMRAAIFKKAEESFEWVWSYHHIILDGWCFGIVVQ DLFKVYNALREQKPYSLPPVKPYKDYIKWLEKQDKQASLRYWREYLEGFEGQTTFAEQ RKKQKDGYEPKELLFSLSEAETKAFTELAKSQHTTLSTALQAVWSVLISRYQQSGDLA FGTVVSGRPAEIKGVEHMVGLFINVVPRRVKLSEGITFNGLLKRLQEQSLQSEPHQYV PLYDIQSQADQPKLIDHIIVFENYPLQDAKNEESSENGFDMVDVHVFEKSNYDLNLMA SPGDEMLIKLAYNENVFDEAFILRLKSQLLTAIQQLIQNPDQPVSTINLVDDREREFL LTGLNPPAQAHETKPLTYWFKEAVNANPDAPALTYSGQTLSYRELDEEANRIARRLQK HGAGKGSVVALYTKRSLELVIGILGVLKAGAAYLPVDPKLPEDRISYMLADSAAACLL THQEMKEQAAELPYTGTTLFIDDQTRFEEQASDPATAIDPNDPAYIMYTSGTTGKPKG NITTHANIQGLVKHVDYMAFSDQDTFLSVSNYAFDAFTFDFYASMLNAARLIIADEHT LLDTERLTDLILQENVNVMFATTALFNLLTDAGEDWMKGLRCILFGGERASVPHVRKA LRIMGPGKLINCYGPTEGTVFATAHVVHDLPDSISSLPIGKPISNASVYILNEQSQLQ PFGAVGELCISGMGVSKGYVNRADLTKEKFIENPFKPGETLYRTGDLARWLPDGTIEY AGRIDDQVKIRGHRIELEEIEKQLQEYPGVKDAVVVADRHESGDASINAYLVNRTQLS AEDVKAHLKKQLPAYMVPQTFTFLDELPLTTNGKVNKRLLPKPDQDQLAEEWIGPRNE MEETIAQIWSEVLGRKQIGIHDDFFALGGHSLKAMTAASRIKKELGIDLPVKLLFEAP TIAGISAYLKNGGSDGLQDVTIMNQDQEQIIFAFPPVLGYGLMYQNLSSRLPSYKLCA FDFIEEEDRLDRYADLIQKLQPEGPLTLFGYSAGCSLAFEAAKKLEEQGRIVQRIIMV DSYKKQGVSDLDGRTVESDVEALMNVNRDNEALNSEAVKHGLKQKTHAFYSYYVNLIS TGQVKADIDLLTSGADFDMPEWLASWEEATTGVYRVKRGFGTHAEMLQGETLDRNAEI LLEFLNTQTVTVS*" gene 398532..402359 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" CDS 402388..403116 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388234.1" /db_xref="EnsemblGenomes-Gn:BSU03520" /db_xref="EnsemblGenomes-Tr:CAB12146" /db_xref="GOA:Q08788" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR012223" /db_xref="InterPro:IPR029058" /db_xref="PDB:2K2Q" /db_xref="PDB:2RON" /db_xref="SubtiList:BG10171" /db_xref="UniProtKB/Swiss-Prot:Q08788" /translation="MSQLFKSFDASEKTQLICFPFAGGYSASFRPLHAFLQGECEMLA AEPPGHGTNQTSAIEDLEELTDLYKQELNLRPDRPFVLFGHSMGGMITFRLAQKLERE GIFPQAVIISAIQPPHIQRKKVSHLPDDQFLDHIIQLGGMPAELVENKEVMSFFLPSF RSDYRALEQFELYDLAQIQSPVHVFNGLDDKKCIRDAEGWKKWAKDITFHQFDGGHMF LLSQTEEVAERIFAILNQHPIIQP*" gene 402388..403116 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" downshifts 403098 /Source="Nicolas_upshifts" /id="D154" /incds=0 /nref=196 /ntot=261 /MaxReadThrough="4.65721" /MaxDrop="6.48992" /score="24.9581454" /energy="-11.1" /TU="U268" /idTUdmin="U268" /TUdmin="-1339" /isTUend="FALSE" promotor_-35 403154..403161 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 403164 /Source="Nicolas_upshifts" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" promotor_-10 403173..403192 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 403217..404443 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15849754, 16850406, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter" /protein_id="NP_388235.2" /db_xref="EnsemblGenomes-Gn:BSU03530" /db_xref="EnsemblGenomes-Tr:CAB12147" /db_xref="GOA:Q08791" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10172" /db_xref="UniProtKB/Swiss-Prot:Q08791" /translation="MRTSPRMKWFVLLFTFVFAIGMNSFRNSFQFFMLPMADAFHADR SLISVSVSIFMITTGIVQFFVGFFIDRFSVRKIMALGAVCISASFLVLPYSPNVHVFS AIYGVLGGIGYSCAVGVTTQYFISCWFDTHKGLALAILTNANSAGLLLLSPIWAAAPY HAGWQSTYTILGIVMAAVLLPLLVFGMKHPPHAQAETVKKSYDWRGFWNVMKQSRLIH ILYFGVFTCGFTMGIIDAHLVPILKDAHVSHVNGMMAAFGAFIIIGGLLAGWLSDLLG SRSVMLSILFFIRLLSLICLLIPILGIHHSDLWYFGFILLFGLSYTGVIPLTAASISE SYQTGLIGSLLGINFFIHQVAGALSVYAGGLFFDMTHGYLLIVAVCIVFVGLSAVIEL VPFLDKQKAKETHHSI*" gene 403217..404443 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" downshifts 404437 /Source="Nicolas_upshifts" /id="D155" /incds=0 /nref=15 /ntot=198 /MaxReadThrough="2.67601" /MaxDrop="4.06773" /score="7.33278866" /energy="-13.2" /TU="NA" /idTUdmin="U268" /TUdmin=0 /isTUend="TRUE" CDS complement(404458..405015) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 21965396" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388236.1" /db_xref="EnsemblGenomes-Gn:BSU03540" /db_xref="EnsemblGenomes-Tr:CAB12148" /db_xref="GOA:Q08793" /db_xref="InterPro:IPR025588" /db_xref="SubtiList:BG10173" /db_xref="UniProtKB/Swiss-Prot:Q08793" /translation="MIQYASESINLPGEITFKDVREIFFYQIAKISCFYFLLFCAIFA AVNFINGWPRIVYGSDALNLFMNSMLIIVMSVLFTLLLLLLLYVKFSRAYKKNERMKS KRTYTLNQEGIRICSKKYDLIFNWDEITAVFEYKNIFRVNTSSGQYIAIPKHFFHSEE EMNRFKEIILKNTETKKLKFKKDQH*" gene complement(404458..405015) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" promotor_no_box complement(404473..404573) /Source="Nicolas_upshift_promotors" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts complement(404495) /Source="Nicolas_upshifts" /id="D156" /incds=0 /nref=46 /ntot=241 /MaxReadThrough="0.9216" /MaxDrop="4.25654" /score="8.42655219" /energy="-14.3" /TU="U270" /idTUdmin="U271" /TUdmin=18 /isTUend="TRUE" upshifts complement(404513) /Source="Nicolas_upshifts" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(405044..405063) /Source="Nicolas_upshift_promotors" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(405046) /Source="Nicolas_upshifts" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" CDS complement(405069..406007) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388237.2" /db_xref="EnsemblGenomes-Gn:BSU03550" /db_xref="EnsemblGenomes-Tr:CAB12149" /db_xref="GOA:Q08794" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10174" /db_xref="UniProtKB/Swiss-Prot:Q08794" /translation="MVKHQQTPAYIAAILYSFIIGLSFLFVKIALQTAEPFDILAHRF TIAFAAATVPILFGWVKLSIRVKDVIDILPLALLYPALFFSFQAFGLVYSSSSEAGII QAAIPIFTMVFAAYVLKERPTWTQKGFTVLSVAGVMFIFVMKGVDVESASLKGSLLIL LSALSSAMYNTAARKMTQRFKLTELTYIMSAIGFVVFNAIALVRHGAAGTVGTYFLPF REPGFVLAIVYLGVLSSLVTSFLSNYTLSRIEAFKMSAFNHVSTIVTMIAGFVILNES LAWYHLAGAVCIMIGVVGSNINLEKKTKRPGMPAKK*" gene complement(405069..406007) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" promotor_-10 complement(406046..406064) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(406053) /Source="Nicolas_upshifts" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(406080..406085) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 406131..407465 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 26585522; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388238.1" /db_xref="EnsemblGenomes-Gn:BSU03560" /db_xref="EnsemblGenomes-Tr:CAB12150" /db_xref="GOA:Q08792" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10175" /db_xref="UniProtKB/Swiss-Prot:Q08792" /translation="MEKYMSLLTRIEEMMQSTSYQEGDRLPSIRQLSARYQVSKSTVI RALQELEKRHLIYSVPKSGYYIVKKSGKSKSGQPGPIDFATSAPDPDVFPYLDFQHCI NKAIDTYKNDLFIYGTPKGLPSLIRVLRKLLATQQVFADERHIFITSGVQQALSLLCA MPFPNGKEKIAIEQPGYHLMVEQLETLGIPAIGVKRTEEGLDIAKVERLFQTESIKFF YTMPRFHNPLGCSLSERDKQELVRLAEAYDVYLVEDDYLGDLEENKKADPLYAYDLSS HVIYLKSFSKMMFPGLRVGAAVLPEALTDTFYAYKKLNDIDCSMISQAALEIYLKSGM YGRHKEKIRDSYKERSLRLHQAIRTHRQLGSGRFTFSSGQAPCMHTHLVLPQDLPASR VIHRLEKQGVLLEAIDRHYLSDYPKENLLKINISNVKTEDIERGVKLLMSHL*" gene 406131..407465 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" CDS complement(407460..407627) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="C-terminal part of 4'-phosphopantetheinyl transferase (Surfactin synthetase-activating enzyme)" /db_xref="PSEUDO:CAX52545.1" /translation="MRLHQDGQVSIELPDSHSPCYIKTYEVDPGYKMAVCAVHPDFPE DITMVSYEELL*" gene complement(407460..407627) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /pseudo CDS complement(407638..408135) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="N-terminal part of 4'-phosphopantetheinyl transferase (surfactin synthetase-activating enzyme)" /db_xref="GOA:P39135" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1QR0" /db_xref="PDB:2GE0" /db_xref="PDB:2GE1" /db_xref="PDB:4MRT" /db_xref="PSEUDO:CAB12151.2" /db_xref="SubtiList:BG10176" /db_xref="UniProtKB/Swiss-Prot:P39135" /translation="MKIYGIYMDRPLSQEENERFMSFISPEKREKCRRFYHKEDAHRT LLGDVLVRSVISRQYQLDKSDIRFSTQEYGKPCIPDLPDAHFNISHSGRWVICAFDSQ PIGIDIEKTKPISLEIAKRFFSKTEYSDLLAKDKDEQTDYFYHLWSMKESFIKQGRQR LIASA*" gene complement(407638..408135) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /pseudo misc_feature complement(408162..408181) /Source="Nicolas_upshift_promotors" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(408174) /Source="Nicolas_upshifts" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" CDS complement(408240..408887) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" /function="15.11: Biosynthesis of natural products" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17827323, 14762003, 16707694, 17827323, 25288929; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein regulating antibiotic production" /protein_id="NP_388240.2" /db_xref="EnsemblGenomes-Gn:BSU03580" /db_xref="EnsemblGenomes-Tr:CAB12152" /db_xref="GOA:O34927" /db_xref="SubtiList:BG12779" /db_xref="UniProtKB/Swiss-Prot:O34927" /translation="MKQELVLRWTFYFAGLIILAFGVSLTIEGKALGISPWDAFHYSL FQHFGLTVGQWSIIIGALIVGFTSLFTRAWPKIGALLNMVLIGVFIDFFNFILPALST YTGSIIVFSLGVVLIGYGVGVYVSAGLGAGPRDSLMMLITEKTGWNVQWVRNGMELTI LFAAWGMGGPIGFGTILTAILTGLILRFSLPQSIQLLNYAVARRTAAVKASPPVH*" gene complement(408240..408887) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" promotor_-10 complement(408916..408935) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(408919) /Source="Nicolas_upshifts" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" promotor_-35 complement(408951..408955) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(409056..409207) /Source="Nicolas_S_feature" /locus_tag="new_409056_409207_c" /HighExp="G180, G135, dia15, H2O2, Diami, S8, Oxctl, G150, LPhT, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S127" CDS complement(409208..409951) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 16513748, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 16513748, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (ATP-binding protein)" /protein_id="NP_388241.2" /db_xref="EnsemblGenomes-Gn:BSU03590" /db_xref="EnsemblGenomes-Tr:CAB12153" /db_xref="GOA:P39456" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11185" /db_xref="UniProtKB/Swiss-Prot:P39456" /translation="MLTVKGLNKSFGENEILKKIDMKIEKGKVIAILGPSGSGKTTLL RCLNALEIPNRGELAFDDFSIDFSKKVKQADILKLRRKSGMVFQAYHLFPHRTALENV MEGPVQVQKRNKEEVRKEAIQLLDKVGLKDKMDLYPFQLSGGQQQRVGIARALAIQPE LMLFDEPTSALDPELVGEVLKVIKDLANEGWTMVVVTHEIKFAQEVADEVIFIDGGVI VEQGPPEQIFSAPKEERTQRFLNRILNPL*" gene complement(409208..409951) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" downshifts complement(409264) /Source="Nicolas_upshifts" /id="D157" /incds=0 /nref=72 /ntot=232 /MaxReadThrough="4.60958" /MaxDrop="4.44283" /score="1.62131565" /energy="-12.6" /TU="U275" /idTUdmin="U276" /TUdmin=4 /isTUend="TRUE" CDS complement(409965..410669) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 15849754, 16850406, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 15849754, 16850406, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (permease)" /protein_id="NP_388242.1" /db_xref="EnsemblGenomes-Gn:BSU03600" /db_xref="EnsemblGenomes-Tr:CAB12154" /db_xref="GOA:P42200" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11186" /db_xref="UniProtKB/Swiss-Prot:P42200" /translation="MFLNNLPALTLGTAIPWDLVQQSFWPILSGGIYYTIPLTILSFI FGMILALITALARMSKVRPLRWVFSVYVSAIRGTPLLVQLFIIFYLFPAFNVTLDPFP SAVIAFSLNVGAYASEIIRASILSVPKGQWEAGYTIGMTHQKTLFRVILPQAFRVSIP PLSNTFISLIKDTSLASQILVAELFRKAQEIGARNLDQILVIYIEAAFIYWIICFLLS LVQHVIERRLDRYVAK*" gene complement(409965..410669) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" CDS complement(410656..411462) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (substrate-binding lipoprotein)" /protein_id="NP_388243.2" /db_xref="EnsemblGenomes-Gn:BSU03610" /db_xref="EnsemblGenomes-Tr:CAB12155" /db_xref="GOA:P42199" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11187" /db_xref="UniProtKB/Swiss-Prot:P42199" /translation="MKKALLALFMVVSIAALAACGAGNDNQSKDNAKDGDLWASIKKK GVLTVGTEGTYEPFTYHDKDTDKLTGYDVEVITEVAKRLGLKVDFKETQWDSMFAGLN SKRFDVVANQVGKTDREDKYDFSDKYTTSRAVVVTKKDNNDIKSEADVKGKTSAQSLT SNYNKLATNAGAKVEGVEGMAQALQMIQQGRVDMTYNDKLAVLNYLKTSGNKNVKIAF ETGEPQSTYFTFRKGSGEVVDQVNKALKEMKEDGTLSKISKKWFGEDVSK*" gene complement(410656..411462) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" promotor_-10 complement(411511..411530) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(411523) /Source="Nicolas_upshifts" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" promotor_-35 complement(411544..411551) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(411578..412450) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17295427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17295427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="HTH-type transcriptional regulator BsdA (LysR family)" /protein_id="NP_388244.1" /db_xref="EnsemblGenomes-Gn:BSU03620" /db_xref="EnsemblGenomes-Tr:CAB12156" /db_xref="GOA:P94403" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12022" /db_xref="UniProtKB/Swiss-Prot:P94403" /translation="MDIRQLRYFITIAQEQKITSAAKKLHMAQPPLSRQLKQLEDELG VVLFDRNKKKQMTLTYEGAVFLKRAKEILHRFEDAVIEVQELKEEVAGTLAVGSTIYC AALMLEKVTQIKERYPHLTFNIWENEPATLLELLESRQIDAAVTTTLIKSDTVQFKQL DDIPCVLVLSDEAGYPCGDTIKMVDIPSFPLILLRPVNGKGVYNQVMNEFHRLNLEPR IVCECHDSATLLSLVSSGFGASILPVTMIPVHMRNHVHTVHIENNPFIMTPAVMWRTD SYLPKPAQQFLDLF*" gene complement(411578..412450) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" promotor_-10 complement(412188..412206) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(412195) /Source="Nicolas_upshifts" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" promotor_-35 complement(412221..412227) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 412504..412511 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(412519..412538) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-10" promotor_-10 412525..412544 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(412525) /Source="Nicolas_upshifts" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" upshifts 412533 /Source="Nicolas_upshifts" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" CDS 412540..413154 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10919793, 15979273, 17295427, 18388975, 26083743, 26658822, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase-flavin prenyltransferase subunit" /protein_id="NP_388245.1" /db_xref="EnsemblGenomes-Gn:BSU03630" /db_xref="EnsemblGenomes-Tr:CAB12157" /db_xref="GOA:P94404" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR004507" /db_xref="InterPro:IPR032901" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG12023" /db_xref="UniProtKB/Swiss-Prot:P94404" /translation="MKAEFKRKGGGKVKLVVGMTGATGAIFGVRLLQWLKAAGVETHL VVSPWANVTIKHETGYTLQEVEQLATYTYSHKDQAAAISSGSFDTDGMIVAPCSMKSL ASIRTGMADNLLTRAADVMLKERKKLVLLTRETPLNQIHLENMLALTKMGTIILPPMP AFYNRPRSLEEMVDHIVFRTLDQFGIRLPEAKRWNGIEKQKGGA*" gene 412540..413154 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" promotor_-35 complement(412552..412559) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-35" CDS 413157..414578 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" /EC_number="4.1.1.61" /EC_number="4.1.1.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11029449, 15979273, 17295427, 18388975, 26658822, 26337367; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phenolic acid decarboxylase subunit;1,4-dihydroxy-2-naphtoate-heptaprenyl diphosphatedecarboxylase" /protein_id="NP_388246.1" /db_xref="EnsemblGenomes-Gn:BSU03640" /db_xref="EnsemblGenomes-Tr:CAB12158" /db_xref="GOA:P94405" /db_xref="InterPro:IPR002830" /db_xref="InterPro:IPR012349" /db_xref="InterPro:IPR032902" /db_xref="SubtiList:BG12024" /db_xref="UniProtKB/Swiss-Prot:P94405" /translation="MAYQDFREFLAALEKEGQLLTVNEEVKPEPDLGASARAASNLGD KSPALLFNNIYGYHNARIAMNVIGSWPNHAMMLGMPKDTPVKEQFFEFAKRYDQFPMP VKREETAPFHENEITEDINLFDILPLFRINQGDGGYYLDKACVISRDLEDPDNFGKQN VGIYRMQVKGKDRLGIQPVPQHDIAIHLRQAEERGINLPVTIALGCEPVITTAASTPL LYDQSEYEMAGAIQGEPYRIVKSKLSDLDVPWGAEVVLEGEIIAGEREYEGPFGEFTG HYSGGRSMPIIKIKRVYHRNNPIFEHLYLGMPWTECDYMIGINTCVPLYQQLKEAYPN EIVAVNAMYTHGLIAIVSTKTRYGGFAKAVGMRALTTPHGLGYCKMVIVVDEDVDPFN LPQVMWALSTKMHPKHDAVIIPDLSVLPLDPGSNPSGITHKMILDATTPVAPETRGHY SQPLDSPLTTKEWEQKLMDLMNK*" gene 413157..414578 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" CDS 414595..414822 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" /EC_number="4.1.1.91" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15979273, 17295427, 18388975, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase subunit" /protein_id="YP_003097675.1" /db_xref="EnsemblGenomes-Gn:BSU03651" /db_xref="EnsemblGenomes-Tr:CAX52546" /db_xref="GOA:C0H3U9" /db_xref="UniProtKB/Swiss-Prot:C0H3U9" /translation="MHTCPRCDSKKGEVMSKSPVEGAWEVYQCQTCFFTWRSCEPESI TNPEKYNPAFKIDPKETETAIEVPAVPERKA*" gene 414595..414822 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" CDS 414819..415283 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15979273, 18388975; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN-binding enzyme subunit" /protein_id="NP_388247.2" /db_xref="EnsemblGenomes-Gn:BSU03652" /db_xref="EnsemblGenomes-Tr:CAB12159" /db_xref="GOA:C0SPB5" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12025" /db_xref="UniProtKB/Swiss-Prot:C0SPB5" /translation="MIRVNCMSDRLFELLDGSCLNEKQHEAFVLQTVSEDGWPHAAMI SAGEIIALSRTDIRIALWKNTMTSANILRTGKAQFTAWWKGAAYYVKLECAPLPPLKD AEYERDRFSCRIVSVKEDVAKYADLTSGVRIQLHSPEEVLSRWKKTLEDLKR*" gene 414819..415283 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" downshifts 415264 /Source="Nicolas_upshifts" /id="D158" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="3.32586" /MaxDrop="3.88166" /score="45.8937489" /energy="-15.1" /TU="NA" /idTUdmin="U278" /TUdmin=0 /isTUend="TRUE" misc_feature 415290..415291 /Source="Nicolas_upshift_promotors" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 415291 /Source="Nicolas_upshifts" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 415350..416195 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388248.2" /db_xref="EnsemblGenomes-Gn:BSU03660" /db_xref="EnsemblGenomes-Tr:CAB12160" /db_xref="GOA:P94407" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12026" /db_xref="UniProtKB/Swiss-Prot:P94407" /translation="MERAGICHSDGFDLAYRIEGEGAPILVIGSAVYYPRLFSSDIKQ KYQWVFVDHRGFAKPKRELRAEDSRLDAVLADIERMRTFLQLEDVTILGHSGHAFMAL EYARTYPKQVRKVALFNTAPDNSEERQRKSESFFMETASLERKKRFEKDIENLPQDID KDPERRFVHMCIRAEAKSFYQERPHAAALWDGVFTNMPIIDELWGNTFARIDLLQRLA DVRMPVYIGLGRYDYLVAPVSLWDAVDGLYPHVDKVIFEKSGHQPMLEEPEAFDQSFR KWLDQ*" gene 415350..416195 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" CDS complement(416235..417713) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8458848, 11717292, 15849754, 16204487, 16850406, 17496096, 23144141, 25966844; Product type t: transporter" /codon_start=1 /transl_table=11 /product="di-tripeptide-proton ABC symporter" /protein_id="NP_388249.2" /db_xref="EnsemblGenomes-Gn:BSU03670" /db_xref="EnsemblGenomes-Tr:CAB12175" /db_xref="GOA:P94408" /db_xref="InterPro:IPR000109" /db_xref="InterPro:IPR005279" /db_xref="InterPro:IPR018456" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12027" /db_xref="UniProtKB/Swiss-Prot:P94408" /translation="MASIDNESIIKSVPQKGFFGHPRGLFTLFFTEFWERFSYYGMRA ILLYYLYTETVNGGLGFDKGTAVAIMSIYGSLVYMSTIIGGWLADRVFGTANTVFYGG IFIMFGHIALAYPGSSIAFYISMVLIIVGTGLLKPNVSSVVGDLYTKEDPRRDSGFSI FYMGINLGGLLAPLIVGTLGQKYNYHLGFGAAAVGMLLGLIVFALTRKKNLGLAGSNV PNPLSKKSAIGTGIGVIIVAIAVIISVQTGVLTIKRFIDLVSILGILIPVIYFIIMFT SKKADKTEKSRLAAYVPLFIGAVMFWAIQEQGATILAVYADERIRLSLGGFELQSSWF QSLNPLFVVIFAPIFAWLWMKLGKRQPSTPVKFSIGIILAGLSFIIMVFPAMQGKEAL VSPLWLVLSFLLVVLGELCLSPVGLSVTTKLAPAAFSAQTMSMWFLTNAAAQAINAQV AGLFDKIPETMYFGTIGLISIVLGGILLLLSPVIKRAMKGVL*" gene complement(416235..417713) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" downshifts complement(416243) /Source="Nicolas_upshifts" /id="D159" /incds=0 /nref=17 /ntot=90 /MaxReadThrough="1.40624" /MaxDrop="3.91827" /score="43.5753464" /energy="-21" /TU="NA" /idTUdmin="U281" /TUdmin=0 /isTUend="TRUE" promotor_-35 417740..417742 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(417741..417760) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 417751 /Source="Nicolas_upshifts" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 417759..417777 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(417761) /Source="Nicolas_upshifts" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" S_feature complement(417763..418267) /Source="Nicolas_S_feature" /locus_tag="new_417763_418267_c" /HighExp="S3, S4, LoTm, S5, S6, T5.0H, T4.0H, M9-stat, S8, T3.30H" /AntisenseName="yclG" /AntisenseCor="0.33937447534762299" /AntisenseRegPval="-7.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S128" promotor_-35 complement(417775..417782) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 417931..417940 /Source="Nicolas_upshift_promotors" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 417953..417972 /Source="Nicolas_upshift_promotors" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 417954 /Source="Nicolas_upshifts" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" CDS 417993..419747 /gene="yclG" /locus_tag="BSU_03680" /old_locus_tag="BSU03680" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative uronase" /protein_id="NP_388250.1" /db_xref="EnsemblGenomes-Gn:BSU03680" /db_xref="EnsemblGenomes-Tr:CAB12176" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR006633" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="InterPro:IPR024535" /db_xref="SubtiList:BG12028" /db_xref="UniProtKB/Swiss-Prot:P94409" /translation="MAEFILNAADFGVPRDGKTDSTERINQCLSTAVSKGYHTVWFPK GTYLIDATLGGDLNQRFRNAGIIVPGNLEIMMDPECIMKVIPNSSWGYSAFYVGKQEN ITISGGQIIGERDEHTYASAGIRSTHEWGFGICIEGCSNVVIDDVKISDFTGDGIIVS PRGLKTNQDYRTSEQIIIRRCEVRRSRRNNISITGCDMVTVEECLIEDAGTGNGTAPK FGIDIEGYGEGDVDYEEPINVSIRNNHFVGNVSSSVTNFNGYGILIEGNHSDNTISYG YGTQTVIKGNILRRPEDAAAAPRVGITGLGVSQGKETSDAVIAGNLITGFSTGIDVRG KSVLVTNNKISNFENTGILVYQSSDVKVDGNQIQNGLSETRRSIGLRAVLSDDIAFLN NCLIQVVDGVNVSGGNMIIKDNLLRKFSRGIWIAQGNAVIEGNTLNPDAFEAVPESYS VSVTNNAGAIIKNNTFKEFKNYPIYCSTSAKTSIIGNHLERSPLLVTIYISAGVHEIF DNTISVNRTAGNPIVIYLNGSAGSIISGNTINNLSAGTATAIQTNTSTNSKIIGNRIF KGTINKHSSDTIDGNMIV*" gene 417993..419747 /gene="yclG" /locus_tag="BSU_03680" /old_locus_tag="BSU03680" promotor_-10 complement(418264..418282) /Source="Nicolas_upshift_promotors" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(418277) /Source="Nicolas_upshifts" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" promotor_-35 complement(418298..418303) /Source="Nicolas_upshift_promotors" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 419738 /Source="Nicolas_upshifts" /id="D160" /incds=0 /nref=6 /ntot=21 /MaxReadThrough="0.325519999999999" /MaxDrop="4.9689" /score="4.29139266" /energy="-5.4" /TU="NA" /idTUdmin="U282" /TUdmin=7 /isTUend="TRUE" CDS complement(419763..419984) /gene="yczF" /locus_tag="BSU_03690" /old_locus_tag="BSU03690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388251.1" /db_xref="EnsemblGenomes-Gn:BSU03690" /db_xref="EnsemblGenomes-Tr:CAB12177" /db_xref="GOA:O31479" /db_xref="SubtiList:BG12780" /db_xref="UniProtKB/Swiss-Prot:O31479" /translation="MKILGVTGFILICLLAISVLMDMLQGFSLTKAVYNNMSSFKMTT FAEWVVLLFFVLVLVREMYVIYKSKKKNP*" gene complement(419763..419984) /gene="yczF" /locus_tag="BSU_03690" /old_locus_tag="BSU03690" promotor_-10 complement(420003..420014) /Source="Nicolas_upshift_promotors" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(420005) /Source="Nicolas_upshifts" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" promotor_-35 complement(420029..420035) /Source="Nicolas_upshift_promotors" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 420050..420056 /Source="Nicolas_upshift_promotors" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 420070..420081 /Source="Nicolas_upshift_promotors" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 420083 /Source="Nicolas_upshifts" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" CDS 420110..421744 /gene="gerKA" /locus_tag="BSU_03700" /old_locus_tag="BSU03700" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 16707705, 16740944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 16707705, 16740944; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388252.1" /db_xref="EnsemblGenomes-Gn:BSU03700" /db_xref="EnsemblGenomes-Tr:CAB12178" /db_xref="GOA:P49939" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG11392" /db_xref="UniProtKB/Swiss-Prot:P49939" /translation="MPLFSKRKNNTDSKDKQNTDERNQEQQQEKERPVLISPSLAKNI AETKKEVGSSSDVIIREIKIGEQDHVHLAVIYISGLVDNNTIHESLIDPLVQDESIQN THAIQQILEKTLPLGGVKAEKSWDKLFSELMLGNALIFADGHDEALICSTQGGEQRSI QEPSTQVSFRGPRQGFTESLQTNISMIRRYIKNPNLWVEKMKKGSVTNTDIALMYIQG ICDEKVLKEVKQRLEKIDIDSILESGYIEQLIEDETFTTFPTMYHTERPDVVAGNLLE GRFAIIVDGTPFVLIAPALFVQFFQSVEDYYSRFDIATSIRILRVLVFFISLVAPAVY VAATTFHQEMIPTQLLVVIAAQREIVPFPAVVEALTMEVAFEILREAGVRLPRVVGSA VSIVGALVIGQAAVQAGIVSPAMVIIVALTAIASFATPAFAMAISARLIRFIFIIASA VMGFYGLILGIIMMFVHLCSLRSFGVPYMSPLAPFSSQGVKDALFRVPWWADEKRPES VSKEDKVRQGKDQRPEPAASRGMVNKDLEEGDQNGT*" gene 420110..421744 /gene="gerKA" /locus_tag="BSU_03700" /old_locus_tag="BSU03700" CDS 421734..422957 /gene="gerKC" /locus_tag="BSU_03710" /old_locus_tag="BSU03710" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 16707705, 16740944, 19363077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 16707705, 16740944, 19363077; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388253.1" /db_xref="EnsemblGenomes-Gn:BSU03710" /db_xref="EnsemblGenomes-Tr:CAB12179" /db_xref="GOA:P49941" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG11394" /db_xref="UniProtKB/Swiss-Prot:P49941" /translation="MVRKCLLAVLMLLSVIVLPGCWDKRELTDLAIISAIGIDRTNDS NYVLHLQIINPGNVAGGLQGGGAGDRPPVSVYSIEGNNITEALRKASMKVSRRLYFAH TNLVVINEKLAKEEGLDFVLDNLDRDTEFRTTATFVVAHKTKAENIVKILTPIDKIPS NKVNKTLDFTEAQYGRVVKINIQDVLKTLAANTMAPVIPGYMMIGDDKKGVSMENTQA TDPKAILQADGLAVFDKAGYLKYWLEDDESVGAVWLMNKIQHTFINADWGKTKDAVSL QVTHQDTKLVPKMRNGRPYIHVKVSVEGIIDAVKYPFQLSDPKVLAAIEKALNKELEK EISHTVKKIKKNKIDFIGFGDTIYRKYPEQWEKMKDTWDKEYLPELPIDVKAETYIRR TGLRNNPIKHQFKDD*" gene 421734..422957 /gene="gerKC" /locus_tag="BSU_03710" /old_locus_tag="BSU03710" CDS 422982..424103 /gene="gerKB" /locus_tag="BSU_03720" /old_locus_tag="BSU03720" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 15849754, 16707705, 16740944, 16850406, 19363077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 15849754, 16707705, 16740944, 16850406, 19363077; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388254.1" /db_xref="EnsemblGenomes-Gn:BSU03720" /db_xref="EnsemblGenomes-Tr:CAB12180" /db_xref="GOA:P49940" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG11393" /db_xref="UniProtKB/Swiss-Prot:P49940" /translation="MEKARISIRQLFVMIIIFELGSSLLITPGSMAGRDAWIAVLLGC AIGLFLFYLYQGIYQCYPNSSPKEYMDDMLGTKLSWLFSFLYILYFAYIAARVLRDFG EMLLTFAYHDTPIIIVNALLMVVSIYAVRKGIEVLARAAELLFGAMYLLGAIGLVLII VSGTIDPHNLKPVLANGISPVLHSVFTQTMYVPFGEVVLFVMIFPNLNDRKDVKKMGM IAMAISGLIVALTVAINISVLDVDLTLRSQFPLLSTIQTIKVEEFLDRLDVFFMLALI IGGFFKVSLYLYATVVGTSTLFKEKNPSQLAYPMGLGILILSITIATNFSEHLNEGLN VVPLYIHLPFQLLFPLFLFIVAVWKKKRREKSKGEEAKK*" gene 422982..424103 /gene="gerKB" /locus_tag="BSU_03720" /old_locus_tag="BSU03720" downshifts 424087 /Source="Nicolas_upshifts" /id="D161" /incds=0 /nref=6 /ntot=58 /MaxReadThrough="2.55658" /MaxDrop="3.73002" /score="3.39927899" /energy="-10.5" /TU="NA" /idTUdmin="U285" /TUdmin=2200 /isTUend="FALSE" CDS complement(424208..424888) /gene="yclH" /locus_tag="BSU_03730" /old_locus_tag="BSU03730" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATPase component)" /protein_id="NP_388255.1" /db_xref="EnsemblGenomes-Gn:BSU03730" /db_xref="EnsemblGenomes-Tr:CAB12181" /db_xref="GOA:P94411" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12029" /db_xref="UniProtKB/Swiss-Prot:P94411" /translation="MSLLQFQQVGYWYKNKSQPLFQDINISFQKGKFYTIVGTSGTGK TTFLSLAGGLDAPKEGNILYDGKAVSKIGLTNFRNQYVSIVFQAYNLLPYMTALQNVT TAMEITGSKEKNKESYALDMLQKVGINEKQARQKVLTLSGGQQQRVSITRAFCCDTDL IVADEPTGNLDEDTSKEIVRLFQDLAHKEDKCVIMVTHDEQIAKVSDINIRLSRGSFT VKENVAVV*" gene complement(424208..424888) /gene="yclH" /locus_tag="BSU_03730" /old_locus_tag="BSU03730" CDS complement(424904..426364) /gene="yclI" /locus_tag="BSU_03740" /old_locus_tag="BSU03740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_388256.2" /db_xref="EnsemblGenomes-Gn:BSU03740" /db_xref="EnsemblGenomes-Tr:CAB12182" /db_xref="GOA:P94412" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG12030" /db_xref="UniProtKB/Swiss-Prot:P94412" /translation="MNFIKRAFWNMKAKKGKTLLQLFVFTVICVFVLSGLAIQSAAQK SSELARQELGGSVTLQVDRQKQMEKQQDSGEKRSFESTPIKVSDANKLAALDHVKSYN YTTSASANAGNFDAIESSSSSDSSSSSSSSNAKNSQGGGQGGPQMVQADLSIEGVIST ALVDDFSDGDSKITDGRAITKSDVGKKVTVINETLAEENDLSVGDSITIESATDEDTT VKLKIVGIYKTTSSGDDQAQNFSFLNPYNKLYTPYTATAALKGDDYKNTIDSAVYYMD DAKNMDTFVKAAKKTSIDFDTYTLNTNDQLYQQMVGPIENVASFSKNVVYLVSVAGAV ILGLIVMMSIRERKYEMGVLMAIGEKRWKLIGQFLTEILIVAVIAIGLASVTGNLVAN QLGNQLLSQQISSSTDSTQTASGQMPGGGGGMGGKMFGHSSSNVDVIDSLNVAVSMND MLILGGIGILIAIIATLLPSISVLRLHPKTILTKQE*" gene complement(424904..426364) /gene="yclI" /locus_tag="BSU_03740" /old_locus_tag="BSU03740" misc_feature 426534..426553 /Source="Nicolas_upshift_promotors" /id="U286" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.647352647352647" /psig="0.962037962037962" /xcortree=1584 /SigmaFactorBS="tctagttgatgaaataaaaactaacaattgtgaaacgcaaaa ccttctgtttaaaatGGTGCTATTATATAAAAAAGcatcaaaacaaccggaggatata a" /listShort="yclJ, yclK, S129, rapC, phrC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 426537 /Source="Nicolas_upshifts" /id="U286" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.647352647352647" /psig="0.962037962037962" /xcortree=1584 /SigmaFactorBS="tctagttgatgaaataaaaactaacaattgtgaaacgcaaaa ccttctgtttaaaatGGTGCTATTATATAAAAAAGcatcaaaacaaccggaggatata a" /listShort="yclJ, yclK, S129, rapC, phrC" /GFF_Attribute="listLong" CDS 426577..427260 /gene="yclJ" /locus_tag="BSU_03750" /old_locus_tag="BSU03750" /function="16.10: Respire" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15375128, 20512483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15375128, 20512483; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YclK] (possibly involved in arabinogalactan metabolism)" /protein_id="NP_388257.1" /db_xref="EnsemblGenomes-Gn:BSU03750" /db_xref="EnsemblGenomes-Tr:CAB12183" /db_xref="GOA:P94413" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12031" /db_xref="UniProtKB/Swiss-Prot:P94413" /translation="MKILMIEDNVSVCTMTEMFFFKEGFEAEFVHDGLEGYQRFTEEN WDLIILDIMLPSMDGVTICRKIRETSTVPIIMLTAKDTESDQVIGFEMGADDYVTKPF SPLTLVARIKAVIRRYKATGKAVIDEDMIETECFTINKKTREVLLNGEPVENLTPKEF DLLYYLVQNPRQVFSREQLLEQVWGYQFYGDERTVDVHIKRLRKKLASEDKPFLYTVW GVGYKFDED*" gene 426577..427260 /gene="yclJ" /locus_tag="BSU_03750" /old_locus_tag="BSU03750" CDS 427247..428668 /gene="yclK" /locus_tag="BSU_03760" /old_locus_tag="BSU03760" /function="16.3: Control" /function="16.10: Respire" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15375128, 20512483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15375128, 20512483; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YclJ]" /protein_id="NP_388258.1" /db_xref="EnsemblGenomes-Gn:BSU03760" /db_xref="EnsemblGenomes-Tr:CAB12184" /db_xref="GOA:P94414" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12032" /db_xref="UniProtKB/Swiss-Prot:P94414" /translation="MMKIKYLYQLLLSHISILILAFVIIISLFSHFVKEFAYQNKVEE LTSYAVQIANEFQSGQVDMRRLYPYQDILSTRKTQFIIFNEEQQPYFLPEGFHHPPRE QLKKSEWNKLKKGQTVTIRADGRFDDEVSLVAQPIFVQNEFKGAVLLISPISGVEQMV NQVNLYMFYAVISTLVITILVSWLLSKFHVKRIQKLREATDKVASGDYDIHLENSYGD EIGVLASDFNIMAKKLKQSRDEIERLEKRRRQFIADVSHELKTPLTTINGLVEGLNSH TIPEDKKDKCFSLISEETKRMLRLVKENLDYEKIRSQQITLNKLDVPLIEVFEIVKEH LQQQAEEKQNKLMIQVEDHVIVHADYDRFIQILVNITKNSIQFTQNGDIWLRGMEGYK ETIIEIEDTGIGIPKEDIEHIWERFYKADISRTNTAYGEYGLGLSIVRQLVEMHQGTV EIKSEEGKGTKFIIRLPLTAKQQ*" gene 427247..428668 /gene="yclK" /locus_tag="BSU_03760" /old_locus_tag="BSU03760" downshifts 428644 /Source="Nicolas_upshifts" /id="D162" /incds=0 /nref=20 /ntot=169 /MaxReadThrough="3.43905" /MaxDrop="4.91565" /score="13.4599201" /energy="-15" /TU="U286" /idTUdmin="U286" /TUdmin="-1427" /isTUend="FALSE" S_feature 428689..428793 /Source="Nicolas_S_feature" /locus_tag="new_428689_428793" /HighExp="Lbstat, nit, ferm, BI, M0t45, M40t45, M0t90, S0, S2, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.962" /TUlongSig="NA" /TUlongPSig="NA" /label="S129" misc_feature 428783..428802 /Source="Nicolas_upshift_promotors" /id="U287" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.986013986013986" /xcortree=678 /SigmaFactorBS="tcccgaaaacaaagattgcgtgtttttcgggttgggacggcc tataaaCATGATAAAATATGACATAAacagtttttgatgggagagggtgaaggaatga a" /listShort="rapC, phrC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 428795 /Source="Nicolas_upshifts" /id="U287" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.986013986013986" /xcortree=678 /SigmaFactorBS="tcccgaaaacaaagattgcgtgtttttcgggttgggacggcc tataaaCATGATAAAATATGACATAAacagtttttgatgggagagggtgaaggaatga a" /listShort="rapC, phrC" /GFF_Attribute="listLong" downshifts complement(428827) /Source="Nicolas_upshifts" /id="D163" /incds=0 /nref=2 /ntot=81 /MaxReadThrough="1.74985" /MaxDrop="4.10695" /score="1.47729412" /energy="-10.3" /TU="NA" /idTUdmin="U290" /TUdmin=1320 /isTUend="FALSE" CDS 428831..429979 /gene="rapC" /locus_tag="BSU_03770" /old_locus_tag="BSU03770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10464187, 12456319, 12897006, 12950917, 15968044, 19202088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464187, 12456319, 12897006, 12950917, 15968044, 19202088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388259.1" /db_xref="EnsemblGenomes-Gn:BSU03770" /db_xref="EnsemblGenomes-Tr:CAB12185" /db_xref="GOA:P94415" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11966" /db_xref="UniProtKB/Swiss-Prot:P94415" /translation="MKSGVIPSSAVGQKINEWYRYIRTFSVPDAEVLKAEIQQELKHM QHDSNLLLYYSLMEFRHQLMLDYLEPLEKLNIEDQPSLSELSRNIDSNQADLKGLLDY YVNFFRGMYEFDKREFISAITYYKQAEKKLSFVADHIERAEFYFKIAEAYYYMKQTYF SLINIKNAYEIYVEQETYNVRIIQCHFVFGVNLMDERNFEQAARHFKLALNMAQAEQK AQLVGRAYYNLGLCYYNQDLLDPAIDYFEKAVSTFESSRIVNSLPQAYFLITLIYYKQ GKHDKASEYHKRGYEYAKETDDADYAVKFEFLQSLYLDQPNEEGIERCFQYLKNKNMY ADIEDLALEVAKYYYEQKWFKLSASYFLQVEEARKQIQRSEGLYEIEI*" gene 428831..429979 /gene="rapC" /locus_tag="BSU_03770" /old_locus_tag="BSU03770" promotor_-35 429679..429684 /Source="Nicolas_upshift_promotors" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 429697 /Source="Nicolas_upshifts" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" promotor_-10 429701..429719 /Source="Nicolas_upshift_promotors" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 429841..429849 /Source="Nicolas_upshift_promotors" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 429861..429879 /Source="Nicolas_upshift_promotors" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 429873 /Source="Nicolas_upshifts" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" CDS 429963..430085 /gene="phrC" /locus_tag="BSU_03780" /old_locus_tag="BSU03780" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464187, 12456319, 12897006, 12950917, 16816200, 19202088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464187, 12456319, 12897006, 12950917, 16816200, 19202088; Product type r : regulator" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapC and competence and sporulation stimulating factor (CSF)" /protein_id="NP_388260.1" /db_xref="EnsemblGenomes-Gn:BSU03780" /db_xref="EnsemblGenomes-Tr:CAB12186" /db_xref="GOA:P94416" /db_xref="InterPro:IPR020243" /db_xref="InterPro:IPR025899" /db_xref="SubtiList:BG11959" /db_xref="UniProtKB/Swiss-Prot:P94416" /translation="MKLKSKLFVICLAAAAIFTAAGVSANAEALDFHVTERGMT*" gene 429963..430085 /gene="phrC" /locus_tag="BSU_03780" /old_locus_tag="BSU03780" downshifts 430072 /Source="Nicolas_upshifts" /id="D164" /incds=0 /nref=260 /ntot=275 /MaxReadThrough="3.24518" /MaxDrop="7.70367" /score="26.3182765" /energy="-14" /TU="NA" /idTUdmin="U286" /TUdmin=1 /isTUend="TRUE" downshifts complement(430140) /Source="Nicolas_upshifts" /id="D165" /incds=0 /nref=3 /ntot=64 /MaxReadThrough="0.60499" /MaxDrop="7.4475" /score="-1.25354129" /energy="-15.8" /TU="NA" /idTUdmin="U290" /TUdmin=7 /isTUend="TRUE" CDS complement(430185..430274) /gene="yczM" /locus_tag="BSU_03788" /old_locus_tag="BSU03788" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097676.1" /db_xref="EnsemblGenomes-Gn:BSU03788" /db_xref="EnsemblGenomes-Tr:CAX52547" /db_xref="GOA:C0H3V0" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3V0" /translation="MSGYGTSFALIVVLFILLIIVGTAFVGGY*" gene complement(430185..430274) /gene="yczM" /locus_tag="BSU_03788" /old_locus_tag="BSU03788" downshifts complement(430345) /Source="Nicolas_upshifts" /id="D166" /incds=0 /nref=25 /ntot=113 /MaxReadThrough="7.05273" /MaxDrop="3.3619" /score="32.1465401" /energy="-16.5" /TU="U290" /idTUdmin="U290" /TUdmin="-198" /isTUend="FALSE" CDS complement(430356..430469) /gene="yczN" /locus_tag="BSU_03789" /old_locus_tag="BSU03789" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore and germination protein" /protein_id="YP_003097677.1" /db_xref="EnsemblGenomes-Gn:BSU03789" /db_xref="EnsemblGenomes-Tr:CAX52548" /db_xref="GOA:C0H3V1" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3V1" /translation="MSGYSNGGGYGGISSFALIVVLFILLIIVGTAFVGGF*" gene complement(430356..430469) /gene="yczN" /locus_tag="BSU_03789" /old_locus_tag="BSU03789" promotor_-10 complement(430490..430509) /Source="Nicolas_upshift_promotors" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(430501) /Source="Nicolas_upshifts" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" promotor_-35 complement(430522..430531) /Source="Nicolas_upshift_promotors" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(430623..431987) /gene="thrD" /locus_tag="BSU_03790" /old_locus_tag="BSU03790" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2152900, 11471740, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2152900, 11471740, 27260660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate kinase III" /protein_id="NP_388261.1" /db_xref="EnsemblGenomes-Gn:BSU03790" /db_xref="EnsemblGenomes-Tr:CAB12187" /db_xref="GOA:P94417" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR035804" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG12033" /db_xref="UniProtKB/Swiss-Prot:P94417" /translation="MKVVKFGGSSLASGAQLDKVFHIVTSDPARKAVVVSAPGKHYAE DTKVTDLLIACAEQYLATGSAPELAEAVVERYALIANELQLGQSIIEKIRDDLFTLLE GDKSNPEQYLDAVKASGEDNNAKLIAAYFRYKGVKAEYVNPKDAGLFVTNEPGNAQVL PESYQNLYRLRERDGLIIFPGFFGFSKDGDVITFSRSGSDITGSILANGLQADLYENF TDVDAVYSVNPSFVENPKEISELTYREMRELSYAGFSVFHDEALIPAFRAGIPVQIKN TNNPSAEGTRVVSKRDNTNGPVVGIASDTGFCSIYISKYLMNREIGFGRRALQILEEH GLTYEHVPSGIDDMTIILRQGQMDAATERSVIKRIEEDLHADEVIVEHHLALIMVVGE AMRHNVGTTARAAKALSEAQVNIEMINQGSSEVSMMFGVKEAEERKAVQALYQEFFAG VLIS*" gene complement(430623..431987) /gene="thrD" /locus_tag="BSU_03790" /old_locus_tag="BSU03790" downshifts complement(430631) /Source="Nicolas_upshifts" /id="D167" /incds=0 /nref=23 /ntot=129 /MaxReadThrough="2.21842" /MaxDrop="4.81019" /score="44.9085917" /energy="-15" /TU="NA" /idTUdmin="U291" /TUdmin=0 /isTUend="TRUE" downshifts complement(430675) /Source="Nicolas_upshifts" /id="D168" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="5.53807" /MaxDrop="2.54279" /score="44.9085917" /energy="-15" /TU="U291" /idTUdmin="U291" /TUdmin="-44" /isTUend="FALSE" promotor_-10 complement(432023..432042) /Source="Nicolas_upshift_promotors" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(432039) /Source="Nicolas_upshifts" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" promotor_-35 complement(432057..432064) /Source="Nicolas_upshift_promotors" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 432178..432182 /Source="Nicolas_upshift_promotors" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 432198..432217 /Source="Nicolas_upshift_promotors" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 432210 /Source="Nicolas_upshifts" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" promotor_-35 432241..432248 /Source="Nicolas_upshift_promotors" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 432262..432281 /Source="Nicolas_upshift_promotors" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 432271..432371 /Source="Nicolas_S_feature" /locus_tag="new_432271_432371" /HighExp="LBGexp, Lbexp, G150, dia0, G135, H2O2, Paraq, dia15, G180, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S130" upshifts 432271 /Source="Nicolas_upshifts" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" CDS 432372..433322 /gene="pbtN" /locus_tag="BSU_03800" /old_locus_tag="BSU03800" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (permease)" /protein_id="NP_388262.1" /db_xref="EnsemblGenomes-Gn:BSU03800" /db_xref="EnsemblGenomes-Tr:CAB12188" /db_xref="GOA:P94418" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12034" /db_xref="UniProtKB/Swiss-Prot:P94418" /translation="MKLRYLFILLIILAVTSVFIGVEDLSPLDLFDLSKQEASTLFAS RLPRLISIVIAGLSMSICGLIMQQISRNKFVSPTTAGTMDWARLGILISLLLFTSASP LIKMLVAFVFALAGNFLFMKILERIKFNDTIFIPLVGLMLGNIVSSIATFIAYKYDLI QNVSSWLQGDFSLVVKGRYELLYLSIPLVIIAYVYADKFTLAGMGESFSVNLGLKYKR VVNIGLIIVSLITSLVILTVGMLPFLGLIIPNIVSIYRGDNLKSSLPHTVLLGAVFVL FCDILGRIIIFPYEISIGLMVGIIGSGIFLFMLLRRKAYA*" gene 432372..433322 /gene="pbtN" /locus_tag="BSU_03800" /old_locus_tag="BSU03800" CDS 433315..434262 /gene="pbtO" /locus_tag="BSU_03810" /old_locus_tag="BSU03810" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (permease)" /protein_id="NP_388263.1" /db_xref="EnsemblGenomes-Gn:BSU03810" /db_xref="EnsemblGenomes-Tr:CAB12189" /db_xref="GOA:P94419" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12035" /db_xref="UniProtKB/Swiss-Prot:P94419" /translation="MRNQMKIALLVGLAIVCIGLFLFYDLGNWDYTLPRRIKKVAAIV LTGGAIAFSTMIFQTITNNRILTPSILGLDSLYMLIQTGIIFLFGSANMVIMNKNINF IISVLLMILFSLVLYQIMFKGEGRNIFFLLLIGIVFGTLFSSLSSFMQMLIDPNEFQV VQDKMFASFNNINTDLLWLAFIIFLLTGVYVWRFTKFFDVLSLGREHAVNLGIDYDKV VKQMLIVVAILVSVSTALVGPIMFLGLLVVNLAREFLKTYKHSYLIAGSVFISIIALV GGQFVVEKVFTFSTTLSVIINFAGGIYFIYLLLKENKSW*" gene 433315..434262 /gene="pbtO" /locus_tag="BSU_03810" /old_locus_tag="BSU03810" CDS 434256..435014 /gene="pbtP" /locus_tag="BSU_03820" /old_locus_tag="BSU03820" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (ATP-binding protein)" /protein_id="NP_388264.1" /db_xref="EnsemblGenomes-Gn:BSU03820" /db_xref="EnsemblGenomes-Tr:CAB12190" /db_xref="GOA:P94420" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12036" /db_xref="UniProtKB/Swiss-Prot:P94420" /translation="MVEVRNVSKQYGGKVVLEETSVTIQKGKITSFIGPNGAGKSTLL SIMSRLIKKDSGEIYIDGQEIGACDSKELAKKMSILKQANQINIRLTIKDLVSFGRFP YSQGRLTEEDWVHINQALSYMKLEDIQDKYLDQLSGGQCQRAFIAMVIAQDTDYIFLD EPLNNLDMKHSVEIMKLLKRLVEELGKTIVIVIHDINFASVYSDYIVALKNGRIVKEG PPEEMIETSVLEEIYDMTIPIQTIDNQRIGVYFS*" gene 434256..435014 /gene="pbtP" /locus_tag="BSU_03820" /old_locus_tag="BSU03820" CDS 435036..435989 /gene="pbtQ" /locus_tag="BSU_03830" /old_locus_tag="BSU03830" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 19955416, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 19955416, 25355936; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (binding lipoprotein)" /protein_id="NP_388265.1" /db_xref="EnsemblGenomes-Gn:BSU03830" /db_xref="EnsemblGenomes-Tr:CAB12191" /db_xref="GOA:P94421" /db_xref="InterPro:IPR002491" /db_xref="InterPro:IPR033870" /db_xref="PDB:3GFV" /db_xref="SubtiList:BG12037" /db_xref="UniProtKB/Swiss-Prot:P94421" /translation="MKKFALLFIALVTAVVISACGNQSTSSKGSDTKKEQITVKHQLD KNGTKVPKNPKKVVVFDFGSLDTLDKLGLDDIVAGLPKQVLPKYLSKFKDDKYADVGS LKEPDFDKVAELDPDLIIISARQSESYKEFSKIAPTIYLGVDTAKYMESFKSDAETIG KIFDKEDKVKDELANIDHSIADVKKTAEKLNKNGLVIMANDGKISAFGPKSRYGLIHD VFGVAPADQNIKASTHGQSVSYEYISKTNPDYLFVIDRGTAIGETSSTKQVVENDYVK NVNAVKNGHVIYLDSATWYLSGGGLESMTQMIKEVKDGLEK*" gene 435036..435989 /gene="pbtQ" /locus_tag="BSU_03830" /old_locus_tag="BSU03830" downshifts 435972 /Source="Nicolas_upshifts" /id="D169" /incds=0 /nref=161 /ntot=280 /MaxReadThrough="3.87669" /MaxDrop="7.4722" /score="31.9942335" /energy="-13.8" /TU="U293" /idTUdmin="U292" /TUdmin=5 /isTUend="TRUE" CDS complement(436036..437454) /gene="ycnB" /locus_tag="BSU_03840" /old_locus_tag="BSU03840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 15855514, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388266.1" /db_xref="EnsemblGenomes-Gn:BSU03840" /db_xref="EnsemblGenomes-Tr:CAB12192" /db_xref="GOA:P94422" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12038" /db_xref="UniProtKB/Swiss-Prot:P94422" /translation="MNTSIEQKPFNRSVIVGILLAGAFVAILNQTLLITALPHIMRDF NVDANQAQWLTTSFMLTNGILIPITAFLIEKFTSRALLITAMSIFTAGTVVGAFAPNF PVLLTARIIQAAGAGIMMPLMQTVFLTIFPIEKRGQAMGMVGLVISFAPAIGPTLSGW AVEAFSWRSLFYIILPFAVIDLILASILMKNVTTLRKTQIDILSVILSTFGFGGLLYG FSSVGSYGWSSSTVLISLLVGVIALLLFITRQMKLKKPMLEFRVFTFGVFSLTTLLGT LVFALLIGTETILPLYTQNVRDVTAFDTGLMLLPGAVVMGFMSPIIGRIFDRVGGRGL AIAGFCIIFLTSLPFMQLTDHTSLAWIVVLYTVRLLGTAMIMMPVTTAGINALPRHLI PHGTAMNNTIRQVGGSIGTALLVSVMSNQAAHAGTTNVKHAALHGMNAAFIVAAVIAL VGFLLSFTLKKPQRPAEQQPAR*" gene complement(436036..437454) /gene="ycnB" /locus_tag="BSU_03840" /old_locus_tag="BSU03840" downshifts complement(436057) /Source="Nicolas_upshifts" /id="D170" /incds=0 /nref=8 /ntot=150 /MaxReadThrough="2.00954" /MaxDrop="5.13029" /score="17.5501827" /energy="-13.8" /TU="NA" /idTUdmin="U294" /TUdmin="-14" /isTUend="TRUE" CDS complement(437474..438352) /gene="ycnC" /locus_tag="BSU_03850" /old_locus_tag="BSU03850" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388267.2" /db_xref="EnsemblGenomes-Gn:BSU03850" /db_xref="EnsemblGenomes-Tr:CAB12193" /db_xref="GOA:P94423" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG12039" /db_xref="UniProtKB/Swiss-Prot:P94423" /translation="MLDKKTDILLAARKLFSEKDFTSVSMQAIAEECKMSKASIYKLF QSKEDLLLELLSFNQKQMVAAASRLQENTALTPEERLTQKVKMELEGFRRNQQFFNML TYGNPKLHNDRVKQHIHQTRSTIICWHRDSLIQAYGETILPFVWDLVIILHGMMREFL MLIKIEEKPLELDPIAEFIISTLNQIIKNRETRQSLLPPEAIELYIHSASSYKPKDKS VLLSESLKELHKGISSLSAADYDVDELTSAAAMLEEEAKKEEPRAFLLKSLIGYLEQT GVLTQPVSMLKTLLIT*" gene complement(437474..438352) /gene="ycnC" /locus_tag="BSU_03850" /old_locus_tag="BSU03850" S_feature complement(438353..438419) /Source="Nicolas_S_feature" /locus_tag="new_438353_438419_c" /HighExp="dia15, H2O2, Diami, Paraq, Oxctl, Cold, G180, Salt, BMM, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S131" promotor_-10 complement(438418..438437) /Source="Nicolas_upshift_promotors" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(438427) /Source="Nicolas_upshifts" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" promotor_-35 complement(438452..438458) /Source="Nicolas_upshift_promotors" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(438516..439265) /gene="nfrAB" /locus_tag="BSU_03860" /old_locus_tag="BSU03860" /EC_number="1.5.1.39" /EC_number="1.6.99.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16229462, 9836433, 20862523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16229462, 9836433, 20862523; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-FMN oxidoreductase (nitroreductase)" /protein_id="NP_388268.1" /db_xref="EnsemblGenomes-Gn:BSU03860" /db_xref="EnsemblGenomes-Tr:CAB12194" /db_xref="GOA:P94424" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR016446" /db_xref="InterPro:IPR029479" /db_xref="PDB:1ZCH" /db_xref="SubtiList:BG12040" /db_xref="UniProtKB/Swiss-Prot:P94424" /translation="MNEVIKSLTDHRSIRSYTDEPVAQEQLDQIIEAVQSAPSSINGQ QVTVITVQDKERKKKISELAGGQPWIDQAPVFLLFCADFNRAKIALEDLHDFKMEITN GLESVLVGAVDAGIALGTATAAAESLGLGTVPIGAVRGNPQELIELLELPKYVFPLSG LVIGHPADRSAKKPRLPQEAVNHQETYLNQDELTSHIQAYDEQMSEYMNKRTNGKETR NWSQSIASYYERLYYPHIREMLEKQGFKVEK*" gene complement(438516..439265) /gene="nfrAB" /locus_tag="BSU_03860" /old_locus_tag="BSU03860" downshifts complement(438529) /Source="Nicolas_upshifts" /id="D171" /incds=0 /nref=136 /ntot=243 /MaxReadThrough="2.08639" /MaxDrop="5.10745" /score="11.1864402" /energy="-18.6" /TU="NA" /idTUdmin="U296" /TUdmin=0 /isTUend="TRUE" CDS complement(439282..439569) /gene="ycnE" /locus_tag="BSU_03870" /old_locus_tag="BSU03870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17274596, 21454635; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AI-2 degrading enzyme" /protein_id="NP_388269.1" /db_xref="EnsemblGenomes-Gn:BSU03870" /db_xref="EnsemblGenomes-Tr:CAB12195" /db_xref="GOA:P94425" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12041" /db_xref="UniProtKB/Swiss-Prot:P94425" /translation="MIVLQAYIKVKPEKREEFLSEAQSLVQHSRAEEGNAQYDLFEKV GEENTFVMLEKWKDEAAMKFHNETAHFQGFVAKGKELLSAPLDVVRTELSE*" gene complement(439282..439569) /gene="ycnE" /locus_tag="BSU_03870" /old_locus_tag="BSU03870" promotor_-35 439535..439542 /Source="Nicolas_upshift_promotors" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 439556..439575 /Source="Nicolas_upshift_promotors" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 439575 /Source="Nicolas_upshifts" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(439613..439632) /Source="Nicolas_upshift_promotors" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(439629) /Source="Nicolas_upshifts" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" promotor_-35 complement(439646..439653) /Source="Nicolas_upshift_promotors" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 439674..439681 /Source="Nicolas_upshift_promotors" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 439686 /Source="Nicolas_upshifts" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" promotor_-10 439692..439711 /Source="Nicolas_upshift_promotors" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 439709..440023 /gene="yczG" /locus_tag="BSU_03880" /old_locus_tag="BSU03880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (ArsR family)" /protein_id="NP_388270.1" /db_xref="EnsemblGenomes-Gn:BSU03880" /db_xref="EnsemblGenomes-Tr:CAB12196" /db_xref="GOA:O31480" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12781" /db_xref="UniProtKB/Swiss-Prot:O31480" /translation="MNIPNHPETETLQLTKVLHALSDPLRLELVKQLAEAKEKTCSTC ADVQVAKSTLSHHFKVLRESGIAQVRIEGKRRYYSLRAEDLEKAFPGLLEAVLNVDQD RW*" gene 439709..440023 /gene="yczG" /locus_tag="BSU_03880" /old_locus_tag="BSU03880" downshifts 440015 /Source="Nicolas_upshifts" /id="D172" /incds=0 /nref=173 /ntot=262 /MaxReadThrough="0.52252" /MaxDrop="5.32898" /score="20.7855667" /energy="-7.4" /TU="NA" /idTUdmin="U297" /TUdmin=0 /isTUend="TRUE" CDS complement(440025..441464) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" /experiment="publication(s) with functional evidences, PMID:15223311, 24127574, 25388514, 27640111, 28348215, 28412355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223311, 24127574, 25388514, 27640111, 28348215, 28412355; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR/MocR family) with PLP binding site (GabR-GABA-PLP aldimine)" /protein_id="NP_388271.1" /db_xref="EnsemblGenomes-Gn:BSU03890" /db_xref="EnsemblGenomes-Tr:CAB12197" /db_xref="GOA:P94426" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4MGR" /db_xref="PDB:4N0B" /db_xref="PDB:4TV7" /db_xref="PDB:5T4J" /db_xref="PDB:5T4K" /db_xref="PDB:5X03" /db_xref="SubtiList:BG12042" /db_xref="UniProtKB/Swiss-Prot:P94426" /translation="MDITITLDRSEQADYIYQQIYQKLKKEILSRNLLPHSKVPSKRE LAENLKVSVNSVNSAYQQLLAEGYLYAIERKGFFVEELDMFSAEEHPPFALPDDLKEI HIDQSDWISFSHMSSDTDHFPIKSWFRCEQKAASRSYRTLGDMSHPQGIYEVRAAITR LISLTRGVKCRPEQMIIGAGTQVLMQLLTELLPKEAVYAMEEPGYRRMYQLLKNAGKQ VKTIMLDEKGMSIAEITRQQPDVLVTTPSHQFPSGTIMPVSRRIQLLNWAAEEPRRYI IEDDYDSEFTYDVDSIPALQSLDRFQNVIYMGTFSKSLLPGLRISYMVLPPELLRAYK QRGYDLQTCSSLTQLTLQEFIESGEYQKHIKKMKQHYKEKRERLITALEAEFSGEVTV KGANAGLHFVTEFDTRRTEQDILSHAAGLQLEIFGMSRFNLKENKRQTGRPALIIGFA RLKEEDIQEGVQRLFKAVYGHKKIPVTGD*" gene complement(440025..441464) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" promotor_-10 complement(440349..440360) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(440355) /Source="Nicolas_upshifts" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(440374..440380) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(441507..441526) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 441508..441515 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(441514) /Source="Nicolas_upshifts" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 441529..441548 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 441533 /Source="Nicolas_upshifts" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" promotor_-35 complement(441537..441544) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 441571..442881 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" /EC_number="2.6.1.19" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-aminobutyrate aminotransferase" /protein_id="NP_388272.1" /db_xref="EnsemblGenomes-Gn:BSU03900" /db_xref="EnsemblGenomes-Tr:CAB12198" /db_xref="GOA:P94427" /db_xref="InterPro:IPR004632" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12043" /db_xref="UniProtKB/Swiss-Prot:P94427" /translation="MSQTTASITTAQWQQKRDQFVSKGVSNGNRSLAVKGEGAELYDL DGRRFIDFAGAIGTLNVGHSHPKVVEAVKRQAEELIHPGFNVMMYPTYIELAEKLCGI APGSHEKKAIFLNSGAEAVENAVKIARKYTKRQGVVSFTRGFHGRTNMTMSMTSKVKP YKFGFGPFAPEVYQAPFPYYYQKPAGMSDESYDDMVIQAFNDFFIASVAPETVACVVM EPVQGEGGFIIPSKRFVQHVASFCKEHGIVFVADEIQTGFARTGTYFAIEHFDVVPDL ITVSKSLAAGLPLSGVIGRAEMLDAAAPGELGGTYAGSPLGCAAALAVLDIIEEEGLN ERSEEIGKIIEDKAYEWKQEFPFIGDIRRLGAMAAIEIVKDPDTREPDKTKAAAIAAY ANQNGLLLLTAGINGNIIRFLTPLVISDSLLNEGLSILEAGLRA*" gene 441571..442881 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" promotor_-35 442759..442765 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 442779..442797 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 442787 /Source="Nicolas_upshifts" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" promotor_-35 442883..442890 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 442905..442924 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 442914 /Source="Nicolas_upshifts" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" CDS 442950..444338 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" /EC_number="1.2.1.24" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate-semialdehyde dehydrogenase" /protein_id="NP_388273.1" /db_xref="EnsemblGenomes-Gn:BSU03910" /db_xref="EnsemblGenomes-Tr:CAB12199" /db_xref="GOA:P94428" /db_xref="InterPro:IPR010102" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="SubtiList:BG12044" /db_xref="UniProtKB/Swiss-Prot:P94428" /translation="MPDQLTVYNPATGEEIKTIPQQSATEVEEAIERSHQAFKTWSKT SANERTSLLKKWYELIVEHKEELADLITKENGKPYQEAVGEVLYGAGYIEWFAEEAKR VYGRTVPAPTTGKRIVVTRQPVGPVAAITPWNFPNAMITRKAAPALAAGCTFIIKPAP DTPLSAYELARLAYEAGIPKDVLQVVIGDGEEIGNVFTSSPKIRKITFTGSTPVGKIL MKNSADTVKHVSMELGGHAPLIVDEDADIDLAVEQAMASKYRNAGQTCVCANRLIVHE SIKDEFAAKLSEQVSKLKVGNGLEEGVNVGPIINKRGFEKIVSQIDDAVEKGAKVIAG GTYDRNDDKGCYFVNPTVLTDVDTSMNIMHEETFGPVAPIVTFSDIDEAIQLANDTPY GLAAYFFTENYRRGIYISENLEYGIIGWNDGGPSAVQAPFGGMKESGIGREGGSEGIE PYLETKYLSIGL*" gene 442950..444338 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" downshifts 444346 /Source="Nicolas_upshifts" /id="D173" /incds=0 /nref=107 /ntot=240 /MaxReadThrough="0.105510000000001" /MaxDrop="6.52053" /score="38.677658" /energy="-19.9" /TU="NA" /idTUdmin="U301" /TUdmin="-3" /isTUend="TRUE" promotor_-35 444396..444402 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 444416..444427 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 444417 /Source="Nicolas_upshifts" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" CDS 444461..445324 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438764, 15849754, 16850406, 19054326, 21564334, 27329749; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glucose uptake protein" /protein_id="NP_388274.1" /db_xref="EnsemblGenomes-Gn:BSU03920" /db_xref="EnsemblGenomes-Tr:CAB12200" /db_xref="GOA:P40420" /db_xref="InterPro:IPR010651" /db_xref="SubtiList:BG11066" /db_xref="UniProtKB/Swiss-Prot:P40420" /translation="MDLLLALLPALFWGSIVLFNVKLGGGPYSQTLGTTIGALIVSIV IYFFVQPVLSLRIFIVGIVSGLFWSLGQANQLKSIQLMGVSKTMPISTGMQLVSTSLF GVIVFREWSTPIAITLGVLALIFIIVGIILTSLEDKNDKKEGEPSNLKKGILILLVST LGYLVYVVVARLFNVSGWSALLPQAIGMVVGGLVLTYRHKPFNKYAIRNILPGLIWAG GNMFLFISQPRVGVATSFSLSQMGIVISTLGGIFILREKKTKRQLIAIAIGIILIIAA AVFLGIAKTNS*" gene 444461..445324 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" CDS 445344..446129 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" /EC_number="1.1.1.47" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2493633, 3141376, 6438057, 16912926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2493633, 3141376, 6438057, 16912926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="forespore glucose 1-dehydrogenase" /protein_id="NP_388275.1" /db_xref="EnsemblGenomes-Gn:BSU03930" /db_xref="EnsemblGenomes-Tr:CAB12201" /db_xref="GOA:P12310" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10545" /db_xref="UniProtKB/Swiss-Prot:P12310" /translation="MYPDLKGKVVAITGAASGLGKAMAIRFGKEQAKVVINYYSNKQD PNEVKEEVIKAGGEAVVVQGDVTKEEDVKNIVQTAIKEFGTLDIMINNAGLENPVPSH EMPLKDWDKVIGTNLTGAFLGSREAIKYFVENDIKGNVINMSSVHEVIPWPLFVHYAA SKGGIKLMTETLALEYAPKGIRVNNIGPGAINTPINAEKFADPKQKADVESMIPMGYI GEPEEIAAVAAWLASKEASYVTGITLFADGGMTQYPSFQAGRG*" gene 445344..446129 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" misc_feature 445449..445468 /Source="Nicolas_upshift_promotors" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 445449 /Source="Nicolas_upshifts" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 445537 /Source="Nicolas_upshifts" /id="D174" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.44884" /MaxDrop="2.47712" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U301" /TUdmin=1188 /isTUend="FALSE" downshifts 446131 /Source="Nicolas_upshifts" /id="D175" /incds=0 /nref=4 /ntot=40 /MaxReadThrough="2.7861" /MaxDrop="4.2307" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U303" /TUdmin="-836" /isTUend="FALSE" CDS complement(446174..446788) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19168619, 22904286, 27010565, 26822828; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative membrane protein involved in copper intake" /protein_id="NP_388276.1" /db_xref="EnsemblGenomes-Gn:BSU03940" /db_xref="EnsemblGenomes-Tr:CAB12202" /db_xref="GOA:P94431" /db_xref="InterPro:IPR012533" /db_xref="SubtiList:BG12045" /db_xref="UniProtKB/Swiss-Prot:P94431" /translation="MLKKIALTLCPAIVGSLLFFTAPASAHVSVKPAESAAGSWETYT MKVPSEKNLPTTKVVLKMPKDVEFQQYEPIPGWKVSTQKHDDKSVSVTWEATDGGIQE GQFQQFTFVAKNPDKAEEAAWDAYQYYKDGSIVEWTGDEDADTPHSITNITSAKQVTD EHGATKTEDDSENSGSSALDITAMVLSAAAIILSVAALVKKKRA*" gene complement(446174..446788) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" downshifts complement(446185) /Source="Nicolas_upshifts" /id="D176" /incds=0 /nref=95 /ntot=219 /MaxReadThrough="0.879290000000001" /MaxDrop="6.67627" /score="21.5633403" /energy="-16" /TU="NA" /idTUdmin="U305" /TUdmin=0 /isTUend="TRUE" CDS complement(446801..448426) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15101989, 15849754, 16850406, 19168619, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 15849754, 16850406, 19168619, 22904286, 23012364; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper import permease subunit" /protein_id="NP_388277.2" /db_xref="EnsemblGenomes-Gn:BSU03950" /db_xref="EnsemblGenomes-Tr:CAB12203" /db_xref="GOA:C0SP95" /db_xref="InterPro:IPR007348" /db_xref="InterPro:IPR008457" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR032693" /db_xref="InterPro:IPR032694" /db_xref="SubtiList:BG12046" /db_xref="UniProtKB/Swiss-Prot:C0SP95" /translation="MKRNRWWIILLLFLVFLPKTSFAHAYIVKSSPGENSELKSAPAQ VEIEFNEPVEEGFHYIKVYNSNGDRVDTDKTEIKKDNHHIMTVKLKKNLPKDVYRAEW NAVSADGHPVSGVIPFSIGKADGGFSSQKAADSALNPGTAADRAILYTALSLFIGTVF FHLFWYKGKSEQLVKRTRRILTGSIAALGLALLLQLPIQTKANAGGGWGSAFQPGYIR ETLFETAGGSIWIIQAALFVLLALSVIPAIRKNRFSSFGYWTAPLIFFFGLLLAKAFT GHAAVVEEKTVGILMDFLHLTSASIWVGGIAALVLLLSKEWRQPDKTLAWETVRRFSP WALTAVGVILFSGLLNGFFIIRSMDSLFHTAYGQALLVKSGLFVFMLVLGAIHFLLTR KQRRTGISRTLKAEWAIGIAVLITAAVFTSLPSPPEPAPEPFYQTKAIENGQSVSLSI SPNQPGKNVFELRVTDHNGDPVKNIQQITLTVYKTGLSGSENKSTFTLKEKTKGVFQD QNLSINEKGNWKIKVHGLTGDFNEINIMFTKTN*" gene complement(446801..448426) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" CDS complement(448461..449033) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 22904286, 23012364; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of copper intake (CutR-Cu(+))" /protein_id="NP_388278.1" /db_xref="EnsemblGenomes-Gn:BSU03960" /db_xref="EnsemblGenomes-Tr:CAB12204" /db_xref="GOA:P94433" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR008719" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12047" /db_xref="UniProtKB/Swiss-Prot:P94433" /translation="MLPINRQQHILKWLKEEGSLRISDISARFGVSEMTVYRDVNQLV QSNQVIKTAGGITLPVRTPQTDHMCSYCLKPVNQAHSVQLITVNQDIEQLCCAHCAFL RYADKTEEVSHLICRDFLLQTTVSAGSAYFVVNAELNLHCCQPQAIPFATLDHAERFQ KGFGGAVCTFDQALEDMLQDRKKRCTCTKK*" gene complement(448461..449033) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" promotor_-10 complement(449055..449074) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(449070) /Source="Nicolas_upshifts" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" promotor_-35 complement(449088..449095) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 449155..449174 /Source="Nicolas_upshift_promotors" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 449167 /Source="Nicolas_upshifts" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" CDS 449198..449551 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18307109, 27010565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative reductase or disulfide isomerase" /protein_id="NP_388279.1" /db_xref="EnsemblGenomes-Gn:BSU03970" /db_xref="EnsemblGenomes-Tr:CAB12205" /db_xref="GOA:P94434" /db_xref="SubtiList:BG12048" /db_xref="UniProtKB/Swiss-Prot:P94434" /translation="MKETPCPNCGKPLTGDMVRSSNVPCQFRCGHCRERLYEYKVSAP IMLVSLAAIVLLIYLLMLLRNAAGSVLPAVQHVPMAVFALVCAYPVFIVSERMIAKYV IQNGNIIYRGKRKGS*" gene 449198..449551 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" downshifts 449522 /Source="Nicolas_upshifts" /id="D177" /incds=0 /nref=136 /ntot=248 /MaxReadThrough="0.860829999999999" /MaxDrop="6.25982" /score="38.4886131" /energy="-13.4" /TU="NA" /idTUdmin="U306" /TUdmin="-19" /isTUend="TRUE" promotor_-35 449615..449622 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 449636..449655 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 449641 /Source="Nicolas_upshifts" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" S_feature 449651..449723 /Source="Nicolas_S_feature" /locus_tag="new_449651_449723" /HighExp="S0, dia5, Gly, G135, B60, T0.30H, BT, G180, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S132" CDS 449724..451160 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IICB component" /protein_id="NP_388280.2" /db_xref="EnsemblGenomes-Gn:BSU03981" /db_xref="EnsemblGenomes-Tr:CAB12206" /db_xref="GOA:P42956" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004718" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR029503" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11215" /db_xref="UniProtKB/Swiss-Prot:P42956" /translation="MQQQEQQQGGMKVKVQRFGSYLSGMIMPNIGAFIAWGIITALFI PAGWFPNEQLNTLVSPMITYLLPLLIAYTGGKMIYDHRGGVVGATAAIGVIVGSDIPM FLGAMIMGPLGGYLIKQTDKLFKDKVKQGFEMLINNFTAGIVGAALTILAFYAIGPVV LTLNKLLAAGVEVIVHANLLPVASVFVEPAKVLFLNNAINHGILSPIGIEQASQTGKS ILFLVEANPGPGLGILLAYMFFGKGSSKSTAPGAAIIHFFGGIHEIYFPYILMKPALI LAAIAGGASGLLTFTIFNAGLVAAASPGSIIALMAMTPRGGYFGVLAGVLVAAAVSFI VSAVILKSSKASEEDLAAATEKMQSMKGKKSQAAAALEAEQAKAEEASELSPESVNKI IFACDAGMGSSAMGASILRNKVKKAELDISVTNTAINNLPSDADIVITHKDLTDRAKA KLPNATHISVDNFLNSPKYDELIEKLKK*" gene 449724..451160 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" CDS 451185..451616 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IIA component" /protein_id="YP_003097678.1" /db_xref="EnsemblGenomes-Gn:BSU03982" /db_xref="EnsemblGenomes-Tr:CAX52549" /db_xref="GOA:C0H3V2" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR016152" /db_xref="UniProtKB/Swiss-Prot:C0H3V2" /translation="MQVLAKENIKLNQTVSSKEEAIKLAGQTLIDNGYVTEDYISKMF EREETSSTFMGNFIAIPHGTEEAKSEVLHSGISIIQIPEGVEYGEGNTAKVVFGIAGK NNEHLDILSNIAIICSEEENIERLISAKSEEDLIAIFNEVN*" gene 451185..451616 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" CDS 451618..452739 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" /EC_number="1.1.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 22014119, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 22014119, 23279188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannitol-1-phosphate 5-dehydrogenase" /protein_id="NP_388281.2" /db_xref="EnsemblGenomes-Gn:BSU03990" /db_xref="EnsemblGenomes-Tr:CAB12207" /db_xref="GOA:P42957" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023027" /db_xref="InterPro:IPR023028" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11216" /db_xref="UniProtKB/Swiss-Prot:P42957" /translation="MIALHFGAGNIGRGFIGALLHHSGYDVVFADVNETMVSLLNEKK EYTVELAEEGRSSEIIGPVSAINSGSQTEELYRLMNEAALITTAVGPNVLKLIAPSIA EGLRRRNTANTLNIIACENMIGGSSFLKKEIYSHLTEAEQKSVSETVGFPNSAVDRIV PIQHHEDPLKVSVEPFFEWVIDESGFKGKTPVINGALFVDDLTPYIERKLFTVNTGHA VTAYVGYQRGLKTVKEAIDHPEIRRVVHSALLETGDYLVKSYGFKQTEHEQYIKKIIG RFENPFISDDVTRVARSPLRKLGENDRLVGPAKKIKEPNALAEGIAAALRFDFTGDPE AVELQALIEEKGYSGVLQEVCGIQSHEPLHAIILKKLNQ*" gene 451618..452739 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" downshifts 452722 /Source="Nicolas_upshifts" /id="D178" /incds=0 /nref=46 /ntot=156 /MaxReadThrough="5.56503" /MaxDrop="4.72154" /score="32.3837677" /energy="-13.4" /TU="U307" /idTUdmin="U308" /TUdmin="-1254" /isTUend="FALSE" promotor_-35 452768..452771 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-35" promotor_-10 452787..452806 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-10" upshifts 452789 /Source="Nicolas_upshifts" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" CDS 452830..453894 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" /EC_number="1.1.1.93" /EC_number="1.1.1.83" /EC_number="4.1.1.73" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10568751, 12356321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tartrate dehydrogenase" /protein_id="NP_388282.3" /db_xref="EnsemblGenomes-Gn:BSU04000" /db_xref="EnsemblGenomes-Tr:CAB12208" /db_xref="GOA:P42958" /db_xref="InterPro:IPR011829" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG11222" /db_xref="UniProtKB/Swiss-Prot:P42958" /translation="MTMKQFEIAAIPGDGVGKEVVAAAEKVLHTAAEVHGGLSFSFTA FPWSCDYYLEHGKMMPEDGIHTLTQFEAVFLGAVGNPKLVPDHISLWGLLLKIRRELE LSINMRPAKQMAGITSPLLHPNDFDFVVIRENSEGEYSEVGGRIHRGDDEIAIQNAVF TRKATERVMRFAFELAKKRRSHVTSATKSNGIYHAMPFWDEVFQQTAADYSGIETSSQ HIDALAAFFVTRPETFDVIVASNLFGDILTDISSSLMGSIGIAPSANINPSGKYPSMF EPVHGSAPDIAGQGLANPIGQIWTAKLMLDHFGEEELGAKILDVMEQVTADGIKTRDI GGQSTTAEVTDEICSRLRKL*" gene 452830..453894 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" promotor_-35 453064..453072 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 453086..453105 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 453096 /Source="Nicolas_upshifts" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 453888 /Source="Nicolas_upshifts" /id="D179" /incds=0 /nref=7 /ntot=41 /MaxReadThrough="4.24123" /MaxDrop="4.42639" /score="9.70532694" /energy="-11.6" /TU="U307,U308" /idTUdmin="U308" /TUdmin="-88" /isTUend="FALSE" promotor_-35 453961..453968 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 453981..454000 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 453994 /Source="Nicolas_upshifts" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" CDS 454029..454592 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11856304, 14568161" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11856304, 14568161; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388283.1" /db_xref="EnsemblGenomes-Gn:BSU04010" /db_xref="EnsemblGenomes-Tr:CAB12209" /db_xref="GOA:P42959" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11223" /db_xref="UniProtKB/Swiss-Prot:P42959" /translation="MNAKTITLKKKRKIKTIVVLSIIMIAALIFTIRLVFYKPFLIEG SSMAPTLKDSERILVDKAVKWTGGFHRGDIIVIHDKKSGRSFVKRLIGLPGDSIKMKN DQLYINDKKVEEPYLKEYKQEVKESGVTLTGDFEVEVPSGKYFVMGDNRLNSLDSRNG MGMPSEDDIIGTESLVFYPFGEMRQAK*" gene 454029..454592 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" S_feature 454593..455317 /Source="Nicolas_S_feature" /locus_tag="new_454593_455317" /HighExp="G150, Oxctl, Lbexp, G135, Paraq, dia0, LBGexp, Mt0, G180, dia15" /AntisenseName="yczH" /AntisenseCor="0.134432865921808" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S133" CDS complement(454652..455260) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388284.2" /db_xref="EnsemblGenomes-Gn:BSU04020" /db_xref="EnsemblGenomes-Tr:CAB12210" /db_xref="GOA:O31482" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12782" /db_xref="UniProtKB/Swiss-Prot:O31482" /translation="MFPKPLVILAHEIYGVNSHMKKMGRLIKMAGYDVLTPNLLGEDE VYTLKEEKTAYEQFTKHERLKTGETIIQNVIRQNAGRHIFVIGFSVGATIAWKCSSMP EVSGSVCYYGSRIRDSLHHMPACPVLLFFPNYEPSFDVALLIKKLREKQHTHLEIYQF DALHGFANPDSVYFNRALFFKTLSIIKNGAESRLRTVSSSFF*" gene complement(454652..455260) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" misc_feature complement(455278..455297) /Source="Nicolas_upshift_promotors" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 455294..455300 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(455301) /Source="Nicolas_upshifts" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" promotor_-10 455313..455332 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 455319 /Source="Nicolas_upshifts" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" CDS 455346..455738 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16291680, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacyl-(acyl carrier protein) dehydratase" /protein_id="NP_388285.2" /db_xref="EnsemblGenomes-Gn:BSU04030" /db_xref="EnsemblGenomes-Tr:CAB12211" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11225" /db_xref="UniProtKB/Swiss-Prot:P42961" /translation="MNSLSLPHRYPFLFIDGVTDSEPGKHAAAYKLISENDWFITDTQ TEMPFSLVIEALAQTAAFTGITDENSLGLLSSVKKAEKLGEAVPGDRLDLTFEVTRNR RGFVFGHAKASVGEQPVAEAEIGIYIEK*" gene 455346..455738 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" downshifts 455715 /Source="Nicolas_upshifts" /id="D180" /incds=0 /nref=23 /ntot=189 /MaxReadThrough="1.8721" /MaxDrop="3.42324" /score="-5.4921522" /energy="-13.6" /TU="NA" /idTUdmin="U310" /TUdmin=0 /isTUend="TRUE" CDS complement(455771..455935) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097679.1" /db_xref="EnsemblGenomes-Gn:BSU04039" /db_xref="EnsemblGenomes-Tr:CAX52550" /db_xref="UniProtKB/Swiss-Prot:C0H3V3" /translation="MTEKKQQNKPNENPEHNDLTDPIPNEELKENMNDEKHKRQQRDN SQSERDYDTK*" gene complement(455771..455935) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" downshifts complement(455791) /Source="Nicolas_upshifts" /id="D181" /incds=0 /nref=101 /ntot=193 /MaxReadThrough="1.44096" /MaxDrop="6.55741" /score="22.582242" /energy="-10.6" /TU="NA" /idTUdmin="U313" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(455945..455963) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(455967) /Source="Nicolas_upshifts" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" promotor_-35 complement(455978..455984) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 455997..456004 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 456018..456037 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 456021 /Source="Nicolas_upshifts" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" CDS 456068..456817 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" /EC_number="3.1.3.-" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 26316208, 27435445, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase / 5' nucleotidase" /protein_id="NP_388286.2" /db_xref="EnsemblGenomes-Gn:BSU04040" /db_xref="EnsemblGenomes-Tr:CAB12212" /db_xref="GOA:P42962" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11226" /db_xref="UniProtKB/Swiss-Prot:P42962" /translation="MSVQREDVDIKLIAIDMDGTLLNDEQLISDENRKAIREAEDKGV YVVISTGRTLMTCRELAESLKLSSFLITANGSEIWDSNFNLVERKLLHTDHIQMMWDL RNKHNTNFWASTVNKVWRGEFPENITDHEWLKFGFDIEDDDIRNEVLEELRKNKELEI TNSSPTNIEVNALGINKAAALAKVTEKLGFTMENVMAMGDSLNDIAMIKEAGLGVAMG NAQDIVKETADYITDTNIEDGVAKAIRHWVL*" gene 456068..456817 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" downshifts 456794 /Source="Nicolas_upshifts" /id="D182" /incds=0 /nref=219 /ntot=253 /MaxReadThrough="3.23506" /MaxDrop="6.84998" /score="19.5535298" /energy="-11.7" /TU="NA" /idTUdmin="U314" /TUdmin="-21" /isTUend="TRUE" downshifts complement(456870) /Source="Nicolas_upshifts" /id="D183" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="0.52326" /MaxDrop="2.84763" /score="25.9755124" /energy="-11.7" /TU="NA" /idTUdmin="U313" /TUdmin="-1079" /isTUend="FALSE" promotor_-35 456900..456906 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 456920..456939 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 456926..457022 /Source="Nicolas_S_feature" /locus_tag="new_456926_457022" /HighExp="S1, Cold, S0, GM 5, BMM, MG 25, Lbtran, aero, GM 10, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S134" upshifts 456926 /Source="Nicolas_upshifts" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" CDS 457023..457796 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxoprolinase subunit A" /protein_id="NP_388287.3" /db_xref="EnsemblGenomes-Gn:BSU04050" /db_xref="EnsemblGenomes-Tr:CAB12213" /db_xref="GOA:P42963" /db_xref="InterPro:IPR005501" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG11227" /db_xref="UniProtKB/Swiss-Prot:P42963" /translation="MFQIDLNCDLGESFGAYKIGLDQDILEYVTSANIACGFHAGDPS VMRKTVALAAERGVKMGAHPGLPDLLGFGRRNMAISPEEAYDLVVYQIGALSGFLKAE GLHMQHVKPHGALYNMAAVDQKLSDAIAKAVYKVDPGLILFGLAESELVKAGERIGLQ TANEVFADRTYQSDGTLTPRSQPDALIESDDAAVTQVIKMVKEGAVKSQQGHDVSLKA DTVCIHGDGAHALTFAQKIRKQLKAAGIEVTAISEQRST*" gene 457023..457796 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" CDS 457811..459025 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9334321, 15849754, 16850406, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-oxoproline transporter" /protein_id="NP_388288.3" /db_xref="EnsemblGenomes-Gn:BSU04060" /db_xref="EnsemblGenomes-Tr:CAB12214" /db_xref="GOA:P42964" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG11228" /db_xref="UniProtKB/Swiss-Prot:P42964" /translation="MEQQKKTAGKKAGSWSLLMGAAFLMATSAIGPGFLTQTATFTNT LAASFGFVILISIILDIFAQTNVWRIIAVSGKRGQEIANMVLPGLGYFIAILVVLGGL AFNIGNIGGAGLGLQVLFGITPETGALISAVIAILIFVIKEAGKAMDRFTQIAGFVMI ILTVYVAATTAPPVGQAVANTFVPEHISIFAIVTLVGGTVGGYITFAGGHRLLDAGIK GKESIPQVTKSSVVGILITSVMRIALFLAVLGVVSKGLHIDESNPAASVFKLAAGNVG YKIFGLIMWSAAITSVIGAAYTSVSFFKTFSPKIEKNSRGIIIGFIVVSTLAFVTIGQ PAKILVLVGSLNGLILPIALGTLLVAAYKKNIVGDYKHPLWLTSTGALVVIVMAVMGI YTLCTQLPQLWS*" gene 457811..459025 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" CDS 459049..459822 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8186229, 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative D-5-oxoproline epimerase" /protein_id="NP_388289.3" /db_xref="EnsemblGenomes-Gn:BSU04070" /db_xref="EnsemblGenomes-Tr:CAB12215" /db_xref="GOA:P42966" /db_xref="InterPro:IPR009906" /db_xref="InterPro:IPR016938" /db_xref="SubtiList:BG11230" /db_xref="UniProtKB/Swiss-Prot:P42966" /translation="MAPKDVRALIREGKINGPTAGMSGGYAQANLVVLKKDLAFDFLL FCQRNQKPCPVLDVTEAGSPVPSLAAPDADIRTDFPKYRIYRHGILTEEVSDITPYWE DDFVGFLIGCSFSFEQALINNGIAVRHIDEGTNVSMYKTNIDCVPAGAFHGQMVVSMR PVPERLAVRAAQVTSRFPAVHGGPIHIGNPGAIGIRDLGKPDFGDAVSIRDGEVPVFW ACGVTPQAVAMNVKPEMVITHAPGHMLITDIRDESLAVL*" gene 459049..459822 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" CDS 459867..460589 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" /EC_number="3.5.2.9" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit B" /protein_id="NP_388290.2" /db_xref="EnsemblGenomes-Gn:BSU04080" /db_xref="EnsemblGenomes-Tr:CAB12216" /db_xref="GOA:P60495" /db_xref="InterPro:IPR003833" /db_xref="InterPro:IPR010016" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR029000" /db_xref="PDB:2KWA" /db_xref="PDB:2ZP2" /db_xref="SubtiList:BG11231" /db_xref="UniProtKB/Swiss-Prot:P60495" /translation="MTVRYQIEQLGDSAMMIRFGEEINEQVNGIVHAAAAYIEEQPFP GFIECIPAFTSLTVFYDMYEVYKHLPQGISSPFESVKRDVEERLAEIAEDYEVNRRIV EIPVCYGGEFGPDLEEVAKINQLSPEEVIDIHTNGEYVVYMLGFAPGFPFLGGMSKRI AAPRKSSPRPSIPAGSVGIAGLQTGVYPISTPGGWQLIGKTPLALFRPQENPPTLLRA GDIVKFVRISEKDYHAYKEESN*" gene 459867..460589 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" CDS 460592..461599 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit C" /protein_id="YP_054571.2" /db_xref="EnsemblGenomes-Gn:BSU04090" /db_xref="EnsemblGenomes-Tr:CAE01447" /db_xref="GOA:Q7WY77" /db_xref="InterPro:IPR003778" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG14193" /db_xref="UniProtKB/Swiss-Prot:Q7WY77" /translation="MKVLKPGLLTTVQDIGRTGYQKYGVLASGAMDTVSLRIANLLIG NGENEAGLEITMMGPGPSFHFSKQTLIAVTGADFTLRINDEEAPLWKPVLIKENSTVS FGPCKLGSRAYLAAAGGIEVPAVMESKSTYVRGSIGGLHGRALQKEDELNIGEMSALS QTILSRLSSQLGKQGFAAPKWSVSRGRFLPLKKNPVIRVLEGKQFAFFTEESKTRFYE EAFRVTPQSDRMGYRLKGEPLELKAPLEMVSEAVSFGTVQVPPDGNPIILLADRQTTG GYPRIAHIISADLPIVSQIMPGEHVQFEPVSLQEAEALAVEREQHIKELKTRMKMEWL T*" gene 460592..461599 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" downshifts 461085 /Source="Nicolas_upshifts" /id="D184" /incds=1 /nref=6 /ntot=27 /MaxReadThrough="5.04721" /MaxDrop="4.5277" /score="-7.2426149" /energy="-12.4" /TU="U315" /idTUdmin="U315" /TUdmin="-1975" /isTUend="FALSE" promotor_no_box 461179..461279 /Source="Nicolas_upshift_promotors" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 461239 /Source="Nicolas_upshifts" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" CDS 461615..462367 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9334321; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the pxp operon (IclR family)" /protein_id="NP_388291.2" /db_xref="EnsemblGenomes-Gn:BSU04100" /db_xref="EnsemblGenomes-Tr:CAB12217" /db_xref="GOA:P42968" /db_xref="InterPro:IPR005471" /db_xref="InterPro:IPR014757" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11214" /db_xref="UniProtKB/Swiss-Prot:P42968" /translation="MQNKNKTVVKSMALLNLFLHKPSLTLSELVSLTGMPKTSVHRMV SSLEEMGFLSRDASGAYSLGLVFLEFGQLVADRLDIRKIAKPVMEELCREVDEAVQLI MRDGNEAIYVEKIEGTQTVRLYTAIGRRSPLYAGACARSILSFLPREEIEAYIKQTEL ISIGSGTITDPEKLLQEIDASVQNGYTVSYSELENYTAAIGAPIFNHERQVAAGISIA GFEARFTEDRLPYLTEKVKDAALQISRKIGYT*" gene 461615..462367 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" promotor_-35 462365..462374 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 462388..462407 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 462398 /Source="Nicolas_upshifts" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" CDS 462431..463072 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" /EC_number="3.1.1.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 17220230, 20057119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 17220230, 20057119; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat phospholipase B" /protein_id="NP_388292.1" /db_xref="EnsemblGenomes-Gn:BSU04110" /db_xref="EnsemblGenomes-Tr:CAB12218" /db_xref="GOA:P42969" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11232" /db_xref="UniProtKB/Swiss-Prot:P42969" /translation="MVLRYTALGDSLTTGRGSGLFSPGFVQRFGDMMEADLKTRTAIN IFARSGLNTEEILGLLSYPYVQKCIRDADMITITGCGNDLIDSVLAYQTSKDETIFSR VSAHCHENFEKMIAKVAEIKGENPSPYAIRVFNLYNPFPEIDIAGKWITSFNSHLETL ASAPHVKIADAYSIFKGKEQEYLSFDGVHPNSKGYQAMAEAVHKLGYKELSVS*" gene 462431..463072 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" downshifts 463058 /Source="Nicolas_upshifts" /id="D185" /incds=0 /nref=106 /ntot=223 /MaxReadThrough="0.550230000000001" /MaxDrop="6.63515" /score="26.7371783" /energy="-11.8" /TU="NA" /idTUdmin="U315" /TUdmin="-2" /isTUend="TRUE" S_feature complement(463070..463495) /Source="Nicolas_S_feature" /locus_tag="new_463070_463495_c" /HighExp="S1, Sw, BC, S2, Lbtran, M0t90, LPhT, BI, M40t45, C90" /AntisenseName="yczI" /AntisenseCor="-0.57558682544748696" /AntisenseRegPval="-24.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S135" downshifts complement(463115) /Source="Nicolas_upshifts" /id="D186" /incds=0 /nref=171 /ntot=252 /MaxReadThrough="1.91715" /MaxDrop="5.13764" /score="6.4765859" /energy="-11.8" /TU="NA" /idTUdmin="U319" /TUdmin="-1" /isTUend="TRUE" promotor_-35 463148..463154 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 463168..463187 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 463169 /Source="Nicolas_upshifts" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" CDS 463245..463490 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388293.1" /db_xref="EnsemblGenomes-Gn:BSU04120" /db_xref="EnsemblGenomes-Tr:CAB12219" /db_xref="GOA:P42970" /db_xref="InterPro:IPR025018" /db_xref="SubtiList:BG12783" /db_xref="UniProtKB/Swiss-Prot:P42970" /translation="MFRIFKMSFAVIIIILALIAFNYTEHTSVIQSVMLVFLGAVMFM QGLEERKKENDGSGAFNIYTAVFVWSVSLIGFTLHII*" gene 463245..463490 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" S_feature 463491..463901 /Source="Nicolas_S_feature" /locus_tag="new_463491_463901" /HighExp="T5.0H, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, M9-stat, T-4.40H, T-3.40H" /AntisenseName="yczJ" /AntisenseCor="-0.20847541933848601" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S136" CDS complement(463496..463783) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388294.1" /db_xref="EnsemblGenomes-Gn:BSU04130" /db_xref="EnsemblGenomes-Tr:CAB12220" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12784" /db_xref="UniProtKB/Swiss-Prot:O31484" /translation="MVREAAMLHIKEGLEQEFEDAFRQAAPIISGMKGYITHSLSKCM EETHKYLLLVEWETLEDHTEGFRGSSEYQEWKALLHRFYTPFPTVEHFQDV*" gene complement(463496..463783) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" misc_feature complement(463804..463823) /Source="Nicolas_upshift_promotors" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(463820) /Source="Nicolas_upshifts" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" promotor_-35 463877..463881 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 463898..463917 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 463903 /Source="Nicolas_upshifts" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" CDS 463934..465940 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8830698, 10648534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830698, 10648534; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="penicillin-binding lipoprotein 3; transpeptidase" /protein_id="NP_388295.1" /db_xref="EnsemblGenomes-Gn:BSU04140" /db_xref="EnsemblGenomes-Tr:CAB12221" /db_xref="GOA:P42971" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR007887" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR032710" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11234" /db_xref="UniProtKB/Swiss-Prot:P42971" /translation="MLKKCILLVFLCVGLIGLIGCSKTDSPEDRMEAFVKQWNDQQFD DMYQSLTKDVKKEISKKDFVNRYKAIYEQAGVKNLKVTAGEVDKDDQDNKTMKHIPYK VSMNTNAGKVSFKNTAVLKLEKTDDEESWNIDWDPSFIFKQLADDKTVQIMSIEPKRG QIYDKNGKGLAVNTDVPEIGIVPGELGDKKEKVIKELAKKLDLTEDDIKKKLDQGWVK DDSFVPLKKVKPDQEKLVSEATSLQGVTRTNVSSRYYPYGEKTAHLTGYVRAITAEEL KKKKEGTYSDTSNIGIAGLENVYEDKLRGTTGWKIYVPQTGEVIAEKKAKDGEDLHLT IDIKTQMKLYDELKDDSGAAVALQPKTGETLALVSAPSYDPNGFIFGWSDKEWKKLNK DKNNPFSAKFNKTYAPGSTIKPIAAAIGIKNGTLKADEKKTIKGKEWQKDSSWGGYSV TRVSERLQQVDLENALITSDNIYFAQNALDMGADTFTKGLKTFGFSEDVPYEFPIQKS SIANDKLDSDILLADTGYGQGQMQMSPLHLATAYTPFVDNGDLVKPTLIKKDSQTADV WHKQVVTKEGAADITKGLKGVVEDERGSAYQPVVKGITVAGKTGTAELKTSKDDKDGT ENGWFVGYDYENKDLLVAMMIQNVQDRGGSHYVVEKAKKQFQSN*" gene 463934..465940 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" S_feature 465941..466041 /Source="Nicolas_S_feature" /locus_tag="new_465941_466041" /HighExp="LBGstat, T5.0H, M0t45, T3.30H, S0, LBGtran, Oxctl, T4.0H, C30, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.946, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S137" CDS 466042..466944 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388296.1" /db_xref="EnsemblGenomes-Gn:BSU04150" /db_xref="EnsemblGenomes-Tr:CAB12222" /db_xref="GOA:P42972" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11235" /db_xref="UniProtKB/Swiss-Prot:P42972" /translation="MQRIQLAEDLQFSRVIHGLWRLNEWNYSDAELLSLIEWCIDHGI TTFDHADIYGGYTCEKLFGNALALSPGLRENIELVTKCGIVLESPERPAHRSHHYNTS KSHILASVEQSLMNLRTDYIDMLLIHRPDPLMDPEGVAEAFQALKCSGKVRYFGVSNF KDHQYRMLESYLPEKLVTNQIELSAYELENMLDGTLNLCQEKRIPPMAWSPLAGGKVF TENTDKDRRVRTALESVQGEIGAASLDEVMYAWLYTHPAGIMPIVGSGKRERISAAIN ALSYKLDQDQWFRIFTAVQGYDIP*" gene 466042..466944 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" downshifts 466924 /Source="Nicolas_upshifts" /id="D187" /incds=0 /nref=48 /ntot=206 /MaxReadThrough="3.20352" /MaxDrop="4.57855" /score="1.36962171" /energy="-10.6" /TU="U320" /idTUdmin="U318" /TUdmin="-8" /isTUend="TRUE" promotor_-35 467017..467024 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 467038..467057 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 467042..467129 /Source="Nicolas_S_feature" /locus_tag="new_467042_467129" /HighExp="S0, Gly, BC, Lbstat, S2, M9-stat, G135, dia5, T0.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S138" upshifts 467042 /Source="Nicolas_upshifts" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" CDS 467130..469214 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188, 24196428, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188, 24196428, 26159071; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, PTS-dependent activator" /protein_id="NP_388297.1" /db_xref="EnsemblGenomes-Gn:BSU04160" /db_xref="EnsemblGenomes-Tr:CAB12223" /db_xref="GOA:P96574" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG12049" /db_xref="UniProtKB/Swiss-Prot:P96574" /translation="MYMTAREQKLLKHLLLQNRYITVTELAELMQVSTRTIHRELKSI KPLMETVGLTLDKQPGKGLKAVGSPEGKQKLLTDLSYEQHEYSADERKLLILCSLLES QEPVKLYTLAHDLQVTNATVSYDLDELEKWISPFGLTLIRKRGFGIQLIGPENAKRKI VGNLIVNRLDIQMFLEAVELNIKGKTDSSEKMFGVVSKGELLKMERILFQLKEKIAFS LSDSSYIALVVHLTYAIERIKLGETITMEQNELEELMNAKEYSSALEIAGELERAFGV TIPEAEVGYITIHLRSANRKYKTEYKAQEIELETALQTKRLIAFISDKIRMDLTKNYS LYEGLIAHLEPAVSRIKENIEIYNPMKEQIKRDYFLLYMAIEEGVEKYFPGMSFSDDE IAFIVLHFGSALEIKKEEAKVKALVVCSSGIGSSKMLASRLKKELPEIESFDMSSLIE LKGKDVQAYDMIVSTVPIPYENIDYIMVSPLLNEEDANQVKQYIKRKIPLILNKKRSS KEEAQQADVPDMLEAAESIGRYMEVIQDVLRHFTLAQLKTNPDHSMLLLELFQQLKKD GLIRDPEKAAVCLAEREKQGGLGIPGTNMALYHLKNDEIVLPFFKMFDLSTPYEVDGM DGNTLRMTRILVMMAPGSLSAEGSEILSAISSAIIESGESMAGFQEEGGQELYQRLNR IFFTWMKEKNIL*" gene 467130..469214 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" downshifts 469201 /Source="Nicolas_upshifts" /id="D188" /incds=0 /nref=107 /ntot=220 /MaxReadThrough="1.91059" /MaxDrop="5.63565" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U321" /TUdmin="-19" /isTUend="TRUE" promotor_-35 469243..469249 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 469263..469281 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 469275 /Source="Nicolas_upshifts" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" S_feature 469286..469367 /Source="Nicolas_S_feature" /locus_tag="new_469286_469367" /HighExp="Etha, S5, S6, ferm, S8, nit, S7, BT, Salt, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S139" promotor_-35 469329..469336 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 469350..469369 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 469369 /Source="Nicolas_upshifts" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" CDS 469426..470937 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA ligase" /protein_id="NP_388298.2" /db_xref="EnsemblGenomes-Gn:BSU04170" /db_xref="EnsemblGenomes-Tr:CAB12224" /db_xref="GOA:P96575" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG12050" /db_xref="UniProtKB/Swiss-Prot:P96575" /translation="METLQHLILHDMPNSEEIEAVKSGDHTLTYKGYRKRINQLANAM LQKGIQKGDRVALLCKNGHPASTVMFAALEIGAVVVPVSWQLKPYEMTGILKASEPKA MFYGAEFKEILDEVLPELSSLCVTMETGTAYETSAEFEALFAGPDHLPETEMVSPDDT ALLMFTSGTTGNPKRCMITHGGIYRYVKKSNSSIARMKGLRFLACHPIYHTSALICIM LGTFAETTFVFTKDQDPVHMLKVIEEEKIQTVMALPVFYTYLLEAWEKHQTDLSSLVI LMTGGTKVPSSLISRYLDIGIPLAHGYGSTEAWGISTWTPDMGMDKAASAGKPVAGVK VKVEDPLTGEELPQGEIGEIVVHTPFLFKGYEDNPEATAKVLQNGWFRTGDSGYVDED GFIFITGRYKDVIIYGGDNVYPDQVEEVIQQIPGILETAVVGIPDPLYGEKPKAFIVK NGGQRITEEDVIAFCKERLSAYKIPEVEFVNELPKNNLGKVKKDVLRNQAVHS*" gene 469426..470937 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" downshifts 470921 /Source="Nicolas_upshifts" /id="D189" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.57376" /MaxDrop="3.70168" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U323" /TUdmin=73 /isTUend="FALSE" CDS complement(470957..471502) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388299.1" /db_xref="EnsemblGenomes-Gn:BSU04180" /db_xref="EnsemblGenomes-Tr:CAB12225" /db_xref="GOA:P96576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12051" /db_xref="UniProtKB/Swiss-Prot:P96576" /translation="MIAGYIMAAENQTLNQWTINQLGITRGDSILEVGFGPGYCMQQM LKREKDVHLHGIDVSEAMLKLAARRVKPKGVRLIQGSIETFPLPASFYDKVISVNNYT IWNDQTKGIKQIYRALKPGGKAAITMQPREADASPEKTKSFGRQMIADFKAAGFEDID IQFKNIKPELSVCATAKKPAT*" gene complement(470957..471502) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" downshifts complement(470990) /Source="Nicolas_upshifts" /id="D190" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="1.44039" /MaxDrop="3.73662" /score="-9.35066962" /energy="-11.5" /TU="NA" /idTUdmin="U324" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(471569..471587) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(471583) /Source="Nicolas_upshifts" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" promotor_-35 complement(471602..471608) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 471644..471650 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-35" upshifts 471662 /Source="Nicolas_upshifts" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" promotor_-10 471665..471683 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-10" CDS 471709..472569 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528, 21520290, 28197687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase" /protein_id="NP_388300.1" /db_xref="EnsemblGenomes-Gn:BSU04190" /db_xref="EnsemblGenomes-Tr:CAB12226" /db_xref="GOA:P80873" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12052" /db_xref="UniProtKB/Swiss-Prot:P80873" /translation="MANYPKELPAQTQSRQPGIESEMNPSPVYEYEDYKGADKLKGKV ALITGGDSGIGRAVSVAYAKEGADIAIVYKDEHEDAEETKKRVEQEGVKCLLIAGDVG EEEFCNEAVEKTVKELGGLDILVNNAGEQHPKESIKDITSEQLHRTFKTNFYSQFYLT KKAIDYLKPGSAIINTTSINPYVGNPTLIDYTATKGAINAFTRTMAQALVKDGIRVNA VAPGPIWTPLIPATFPEETVAQFGQDTPMGRPGQPVEHVGCYVLLASDESSYMTGQTL HVNGGNFVTT*" gene 471709..472569 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" CDS 472585..473088 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" /EC_number="5.3.1.15" /experiment="publication(s) with functional evidences, PMID:10220166, 15805528, 21421786, 21520290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15805528, 21421786, 21520290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lyxose ketol isomerase" /protein_id="NP_388301.1" /db_xref="EnsemblGenomes-Gn:BSU04200" /db_xref="EnsemblGenomes-Tr:CAB12227" /db_xref="GOA:P96578" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:2Y0O" /db_xref="SubtiList:BG12053" /db_xref="UniProtKB/Swiss-Prot:P96578" /translation="MGITKEEVNSYYQKAGIVLTDEEVDQIQLMDYGLGKERKVGLQL FVYVNTDRYCSKELVLFPGQTCPEHRHPPVDGQEGKQETFRCRYGKVYLYVEGEKTPL PKVLPPQEDREHYTVWHEIELEPGGQYTIPPNTKHWFQAGEEGAVVTEMSSTSTDKHD IFTDPRI*" gene 472585..473088 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" downshifts 473069 /Source="Nicolas_upshifts" /id="D191" /incds=0 /nref=16 /ntot=26 /MaxReadThrough="4.81615" /MaxDrop="6.21035" /score="29.8440619" /energy="-15.5" /TU="U325" /idTUdmin="U325" /TUdmin="-683" /isTUend="FALSE" promotor_-35 473117..473124 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 473138..473157 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 473140 /Source="Nicolas_upshifts" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" CDS 473174..473725 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" /EC_number="2.3.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15468321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal protein N-acetyltransferase" /protein_id="NP_388302.1" /db_xref="EnsemblGenomes-Gn:BSU04210" /db_xref="EnsemblGenomes-Tr:CAB12228" /db_xref="GOA:P96579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1NSL" /db_xref="SubtiList:BG12054" /db_xref="UniProtKB/Swiss-Prot:P96579" /translation="MFTCKVNEHITIRLLEPKDAERLAELIIQNQQRLGKWLFFAENP SSADTYRETIIPDWRRQYADLNGIEAGLLYDGSLCGMISLHNLDQVNRKAEIGYWIAK EFEGKGIITAACRKLITYAFEELELNRVAICAAVGNEKSRAVPERIGFLEEGKARDGL YVNGMHHDLVYYSLLKREWEGEK*" gene 473174..473725 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" promotor_-35 473740..473746 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 473761..473779 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 473774 /Source="Nicolas_upshifts" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" CDS 473803..474225 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_388303.1" /db_xref="EnsemblGenomes-Gn:BSU04220" /db_xref="EnsemblGenomes-Tr:CAB12229" /db_xref="GOA:P80238" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG19017" /db_xref="UniProtKB/Swiss-Prot:P80238" /translation="MNQQDIKQKVLDVLDHHKVGSLATVQKGKPHSRYMTFFHDGLTI YTPTSKETHKAEEIENNPNVHILLGYDCEGFGDAYVEVAGKAKINNSAELKDKIWSSK LERWFDGKDDPNLVILEIEPEDIRLMNAGEKTPVSLEL*" gene 473803..474225 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" promotor_-35 474230..474238 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 474249..474268 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 474268..474634 /Source="Nicolas_S_feature" /locus_tag="new_474268_474634" /HighExp="Etha, Salt, Cold, Sw, B60, Gly, M9-stat, LPhT, B36, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.999, 1" /TUlongSig="SigB" /TUlongPSig=1 /label="S140" upshifts 474268 /Source="Nicolas_upshifts" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" promotor_no_box complement(474294..474394) /Source="Nicolas_upshift_promotors" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" misc_RNA complement(474329..474597) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" /product="small regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 23457461" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 23457461; Product type n: RNA" gene complement(474329..474597) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" upshifts complement(474334) /Source="Nicolas_upshifts" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 474591 /Source="Nicolas_upshifts" /id="D192" /incds=0 /nref=124 /ntot=275 /MaxReadThrough="2.67264" /MaxDrop="7.35087" /score="29.9942993" /energy="-12" /TU="NA" /idTUdmin="U326" /TUdmin=3 /isTUend="TRUE" promotor_-35 474671..474680 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 474693..474708 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 474698 /Source="Nicolas_upshifts" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" CDS 474731..475540 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_388304.1" /db_xref="EnsemblGenomes-Gn:BSU04230" /db_xref="EnsemblGenomes-Tr:CAB12230" /db_xref="GOA:P96581" /db_xref="InterPro:IPR021260" /db_xref="SubtiList:BG12055" /db_xref="UniProtKB/Swiss-Prot:P96581" /translation="MHVITTQVLFIFCFLLLIHSIETLAYATRLSGARVGFIASALSL FNVMVIVSRMSNMVQQPFTGHLIDDAGKNALAIVGEQFRFLIFGSTVGTILGIILLPS FVALFSRAIIHLAGGGGSVFQVFRKGFSKQGFKNALSYLRLPSISYVKGFHMRLIPKR LFVINMLITSIYTIGVLSALYAGLLAPERSTTAVMASGLINGIATMLLAIFVDPKVSV LADDVAKGKRSYIYLKWTSVTMVTSRVAGTLLAQLMFIPGAYYIAWLTKWF*" gene 474731..475540 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" downshifts 475521 /Source="Nicolas_upshifts" /id="D193" /incds=0 /nref=5 /ntot=103 /MaxReadThrough="2.92236" /MaxDrop="3.54247" /score="15.7032536" /energy="-14.9" /TU="U330" /idTUdmin="U327" /TUdmin=911 /isTUend="FALSE" CDS complement(475584..475874) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388305.1" /db_xref="EnsemblGenomes-Gn:BSU04240" /db_xref="EnsemblGenomes-Tr:CAB12231" /db_xref="GOA:O31485" /db_xref="InterPro:IPR023845" /db_xref="SubtiList:BG12807" /db_xref="UniProtKB/Swiss-Prot:O31485" /translation="MLHTPIGRLRTMGFIEGMSLLILLFIAMPLKYWAGLPLAVTIVG SVHGGLFILYLLVLAYATFSVKWPLKWSAAGFIAAFVPFGNFLYDRGLRNYK*" gene complement(475584..475874) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" downshifts complement(475588) /Source="Nicolas_upshifts" /id="D194" /incds=0 /nref=235 /ntot=260 /MaxReadThrough="1.23465" /MaxDrop="7.74945" /score="10.1798531" /energy="-14.9" /TU="NA" /idTUdmin="U332" /TUdmin=0 /isTUend="TRUE" misc_feature complement(475902..475921) /Source="Nicolas_upshift_promotors" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 475902..475920 /Source="Nicolas_upshift_promotors" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 475908 /Source="Nicolas_upshifts" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(475918) /Source="Nicolas_upshifts" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" promotor_-35 475996..476003 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 476017..476036 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 476021 /Source="Nicolas_upshifts" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" CDS 476059..476493 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9341680, 10606655, 10913073, 12458218, 16407330, 16528101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341680, 10606655, 10913073, 12458218, 16407330, 16528101; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388306.1" /db_xref="EnsemblGenomes-Gn:BSU04250" /db_xref="EnsemblGenomes-Tr:CAB12232" /db_xref="GOA:P96582" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2CFX" /db_xref="SubtiList:BG12056" /db_xref="UniProtKB/Swiss-Prot:P96582" /translation="MKLDQIDLNIIEELKKDSRLSMRELGRKIKLSPPSVTERVRQLE SFGIIKQYTLEVDQKKLGLPVSCIVEATVKNADYERFKSYIQTLPNIEFCYRIAGAAC YMLKINAESLEAVEDFINKTSPYAQTVTHVIFSEIDTKNGRG*" gene 476059..476493 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" promotor_-35 476490..476493 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 476502 /Source="Nicolas_upshifts" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" promotor_-10 476510..476529 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 476558..478741 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" /EC_number="5.99.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16192570, 16556226; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase III" /protein_id="NP_388307.1" /db_xref="EnsemblGenomes-Gn:BSU04260" /db_xref="EnsemblGenomes-Tr:CAB12233" /db_xref="GOA:P96583" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005738" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR034144" /db_xref="SubtiList:BG11979" /db_xref="UniProtKB/Swiss-Prot:P96583" /translation="MSKTVVLAEKPSVGRDLARVLKCHKKGNGYLEGDQYIVTWALGH LVTLADPEGYGKEFQSWRLEDLPIIPEPLKLVVIKKTGKQFNAVKSQLTRKDVNQIVI ATDAGREGELVARWIIEKANVRKPIKRLWISSVTDKAIKEGFQKLRSGKEYENLYHSA VARAEADWIVGINATRALTTKFNAQLSCGRVQTPTLAMIAKREADIQAFTPVPYYGIR AAVDGMTLTWQDKKSKQTRTFNQDVTSRLLKNLQGKQAVVAELKKTAKKSFAPALYDL TELQRDAHKRFGFSAKETLSVLQKLYEQHKLVTYPRTDSRFLSSDIVPTLKDRLEGME VKPYAQYVSQIKKRGIKSHKGYVNDAKVSDHHAIIPTEEPLVLSSLSDKERKLYDLIA KRFLAVLMPAFEYEETKVIAEIGGETFTAKGKTVQSQGWKAVYDMAEEDDEQEDDRDQ TLPALQKGDTLAVRTLTETSGQTKPPARFNEGTLLSAMENPSAFMQGEEKGLVKTLGE TGGLGTVATRADIIEKLFNSFLIEKKGQDIFITSKGKQLLQLVPEDLKSPALTAEWEQ KLSAIAAGKLKSAVFIKDMKAYAHQTVKEIKNSSQTFRHDNITGTACPECGKMMLKVN GKRGTMLVCQDRECGSRKTIARKTNARCPNCHKRMELRGQGEGQTFACVCGHREKLSV FEKRKNKDKARATKRDVSSYMKKQNKDEPINNALAEQLKKLGLDK*" gene 476558..478741 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" downshifts 478724 /Source="Nicolas_upshifts" /id="D195" /incds=0 /nref=133 /ntot=245 /MaxReadThrough="3.22367" /MaxDrop="6.18597" /score="23.5229393" /energy="-10.4" /TU="U334" /idTUdmin="U333" /TUdmin=0 /isTUend="TRUE" promotor_-35 478790..478796 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 478811..478829 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 478812..478943 /Source="Nicolas_S_feature" /locus_tag="new_478812_478943" /HighExp="Etha, Salt, Heat, Cold, H2O2, G180, LPhT, Oxctl, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S141" upshifts 478812 /Source="Nicolas_upshifts" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" CDS 478944..480032 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15661000, 26078454, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15661000, 26078454, 27897378; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="glycosyl hydrolase lipoprotein" /protein_id="NP_388308.1" /db_xref="EnsemblGenomes-Gn:BSU04270" /db_xref="EnsemblGenomes-Tr:CAB12234" /db_xref="GOA:O31486" /db_xref="InterPro:IPR008928" /db_xref="SubtiList:BG12057" /db_xref="UniProtKB/Swiss-Prot:O31486" /translation="MRHVLIAVILFFLSIGLSAGCAEAGNKTQNQSATEVNASPLQPA EYFIYHNLMNDKGLIKTDFSDQPSYLSESLGLWMEFLLSKNDAPHFQDQYQHLTDSFL MSNHLVTWKIQNGQASGTNALIDDMRIMLSLDQAAAKWGRSDYAQTARDIGTSLKTYN MNNGFFTDFYDSQAASKDVTLSYVMPDALAVLKKNGIIDEETEQRNANVLYSAPLKNG FLPKTYSSETKEYTYDSEINLIDQLYAAWHLPEGDEKASVLADWIKQEFQKNGKLYGR YSAYTKEPAVQYESPSVYALAVLFLTKQHENSSVIKAIYDRMNDFEIHDPVKSYYGGY MSGTQTHSFDNLLPLLAERKLFNENIIQ*" gene 478944..480032 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" CDS 480013..480864 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23893111, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111, 27897378; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic-di-GMP receptor" /protein_id="NP_388309.1" /db_xref="EnsemblGenomes-Gn:BSU04280" /db_xref="EnsemblGenomes-Tr:CAB12235" /db_xref="GOA:P96585" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG12058" /db_xref="UniProtKB/Swiss-Prot:P96585" /translation="MKISFSESQKLFAYFSGLIAALSLFIYYVSAQQSEGALILCITF GVIAAGIWFGPIYALAVTLIVLFVLGTLMMFFQTGQTSLFPAEEGLRMLVVWGIALLL FSFISGRIHDITAELRRSMTRLQSEIKSYVAVDRVTGFDNKQRMKLELSEEIKRAERY GNSFVFLLLHMHYFKEFKSLYGEKETDRLFQYVGQQIRTSVRETDKKFRPSDERIGIV LTHTPAEHMPAVLTKLKKQLDTYQLENGKYVSLTFHVCYLPYRNDIQTADQFLEELEN EMMMNEL*" gene 480013..480864 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" CDS 480875..482584 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27897378; Product type ph :phenotype" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388310.1" /db_xref="EnsemblGenomes-Gn:BSU04290" /db_xref="EnsemblGenomes-Tr:CAB12236" /db_xref="GOA:O31487" /db_xref="InterPro:IPR018763" /db_xref="SubtiList:BG12059" /db_xref="UniProtKB/Swiss-Prot:O31487" /translation="MLCVMMLLFSAIASFPVSAQAKDQDAGILIIYSTLDGKESSQVK MLDLLAGHFTSHVTVKKDSDVEASDFKGKDHVIYYGQTKRKLSQKLLSLISGVKKPVV AIGYNAGQISQFSGLSLARKENVFQVHSRSEKADVSLESGLNVLSVSGLKGTALYTFK ADEGTTHSFIWKTKKGNVYIGLTNLLNDNLIVAKQLREAFGEKAGTTLLYLRLEDISP MSDEKLLLQAGTYLHKRHIPFILAVIPVYLNPETGDKVYLSNQPKMVKVLKKLQSMGG SIIVHGYTHAYRYSETGEGFEFWDAKADQPITSGNAEDPPSILEKEQDFPNEQAYHSY LEPFREKEETYTKQKLTRAIEDLTSSGLYPLAFEAPHYTMSEYGYQIASQYFTSIFGQ VQLSSTTWKTSGAPPFVTAPSMLHGMTLYPETIGFVDTSKQNPLGEMEEHISQMIDFE GGVAGGFYHPYLGMKYLPELVDQMERIPDSEWLDLKKTKQTVKTDKVEIHTSGDGTIQ VKNGVSPIYEFFDHHRQTPLEKALWILSAVVLLFVIMFVSYTFYLRATLKKRIFKERR SLG*" gene 480875..482584 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" CDS 482577..483839 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" /EC_number="2.4.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378, 28296273; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase associated to biofilm formation" /protein_id="NP_388311.1" /db_xref="EnsemblGenomes-Gn:BSU04300" /db_xref="EnsemblGenomes-Tr:CAB12237" /db_xref="GOA:P96587" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12060" /db_xref="UniProtKB/Swiss-Prot:P96587" /translation="MGNTLFFISLSLIWVMLLYHMFLMQGGFRHYMTFERNIPKWREN MKELPKVSVLIPAHNEEVVIRQTLKAMVNLYYPKDRLEIIVVNDNSSDRTGDIVNEFS EKYDFIKMVITKPPNAGKGKSSALNSGFAESNGDVICVYDADNTPEKMAVYYLVLGLM NDEKAGAVVGKFRVINAAKTLLTRFINIETICFQWMAQGGRWKWFKIATIPGTNFAIR RSIIEKLGGWDDKALAEDTELTIRVYNLGYHIRFFPAAITWEQEPETWKVWWRQRTRW ARGNQYVVLKFLAQFFKLKRKRIIFDLFYFFFTYFLFFFGVIMSNAIFVVNLFYDLHL SVGFLAMILWILAFFLFMTEVMITLSIEKTEMNKQNFFIVFLMYFTYSQAWIVLVIYS LFVEIKHRLFKQEVKWYKTERYNQHKSG*" gene 482577..483839 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" CDS 483845..485956 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative regulator of exopolysaccharide synthesis" /protein_id="NP_388312.1" /db_xref="EnsemblGenomes-Gn:BSU04310" /db_xref="EnsemblGenomes-Tr:CAB12238" /db_xref="GOA:O31488" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR018513" /db_xref="SubtiList:BG12061" /db_xref="UniProtKB/Swiss-Prot:O31488" /translation="MKQIMIFLTSFMLLAMTGQTALAKDVQVSGSLLGKSSQEQAKQQ VLTSELITLYGSKDSAELTYQIPAGASSGNQQLVIEYEASNLLISPSSLTVVIDDEPV KTLKLDGDSKRKTVKLNLNKSQSAQGYHNVSLKFYGVMKEGVCVRQDTSGNWIKIYPD SRLTLADSSEAKGTSLDHYPYPFAQSGNTAEETAIVIPDNPSSAEIEAAVKTEGYLKT VDSSVSIAYVTESELKKIDKPTIVIGVDKHWNGKVKKLLKQAGLQAKGENLLLAERVL KAEGKQQPVLFAQAASEDALTKKISVMTDQTYTGQLSGDTLSISKLQQTEKKESDKLT LENFGAGDITIGADKTSSAHYFYPASAVLDENQSAKLSLKLKKSETIQASTAENESAS QAAELKVMINGQPHSVRLDELGKEDKNGFYHVTVKVDPKLLQKNRYIDIQFVTTGLKE NNPCNTTDEEKWVFIDKNSTLSYAIKGMSPSADFQEWPLPYAGNQDQTTLIVLPDTVS QSKLEELSLVTESFGNEAQHSYTVKKSSDVTANDAKGRNLIFIGGINQFSLLKEKSSD LLVPQEKNGSFDVSSFEMLNETTKQVVFTQASVWDSRYTMAVFAPSKGDGTAVTKEII SYLNSNDESATVLNETNSQQVFTNHQQLKSETNSSDAEQPTQDHSQKWMYIGVLALIM VVAAVFIWIAVRRKKRKTDTE*" gene 483845..485956 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" downshifts 485940 /Source="Nicolas_upshifts" /id="D196" /incds=0 /nref=18 /ntot=91 /MaxReadThrough="0.438479999999999" /MaxDrop="4.36576" /score="34.1370207" /energy="-9.9" /TU="NA" /idTUdmin="U336" /TUdmin="-4598" /isTUend="FALSE" promotor_-35 486053..486060 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 486075..486094 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 486082 /Source="Nicolas_upshifts" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" misc_RNA 486092..486235 /gene="swaO" /locus_tag="BSU_misc_RNA_7" /product="ATP-, cyclic di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 20511502, 23086297, 25086507, 25086509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 20511502, 23086297, 25086507, 25086509; Product type n: RNA" /function="16.3: Control" gene 486092..486235 /gene="swaO" /locus_tag="BSU_misc_RNA_7" downshifts 486233 /Source="Nicolas_upshifts" /id="D197" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="7.43698" /MaxDrop="5.83561" /score="30.4392599" /energy="-14.7" /TU="U336" /idTUdmin="U336" /TUdmin="-4305" /isTUend="FALSE" S_feature 486278..486431 /Source="Nicolas_S_feature" /locus_tag="new_486278_486431" /HighExp="LPhT, LBGstat, LPh, T-1.10H, T-0.40H, G135, G180, T-1.40H, G150, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S142" CDS 486432..488255 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cyclic di-AMP controlled transporter of potassium" /protein_id="NP_388313.1" /db_xref="EnsemblGenomes-Gn:BSU04320" /db_xref="EnsemblGenomes-Tr:CAB12239" /db_xref="GOA:P96589" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12062" /db_xref="UniProtKB/Swiss-Prot:P96589" /translation="MYHSIKRFLIGKPLKSQAAGEQKLTKLKALAMLSSDALSSVAYG TEQILIILATISAAAFWYSIPIAVGVLILLLALILSYRQIIYAYPQGGGAYIVSKENL GEKPGLIAGGSLLVDYILTVAVSISAGTDAITSAFPALHDYHVPIAIFLVLVIMILNL RGLSESASILAYPVYLFVVALLVLIAVGLFKLMTGQIDQPAHHTSLGTPVAGITLFLL LKAFSSGCSALTGVEAISNAIPAFKNPPARNAARTLAMMGILLAILFSGITVLAYGYG TAPKPDETVVSQIASETFGRNVFYYVIQGVTSLILVLAANTGFSAFPQLAFNLARDQY MPRMFTVRGDRLGFSNGIIFLGFASIVLIILFGGQTEHLIPLYAVGVFIPFTLSQTGM CMKWIKQKPKGWIGKMLINSCGALISFMVLSILFVTKFNVVWPVLIFMPIVVLLFFAI KNHYTAVGEQLRIVDKEPEEIKGTVVIVPVAGVTTVVQKSIHYAKSLSDQVIAVHVSF DREQEKKFEKRWEELNNGVRLVTLHSSYRSLVHPFDKFLETVEAKAKKEQFSVMVLFP QFITKKRWHTILHNQSAFLLRVRLFWKKDIMVATLPYHFKK*" gene 486432..488255 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" downshifts 488247 /Source="Nicolas_upshifts" /id="D198" /incds=0 /nref=50 /ntot=181 /MaxReadThrough="3.55206" /MaxDrop="4.7232" /score="6.00201196" /energy="-13.9" /TU="U336" /idTUdmin="U336" /TUdmin="-2291" /isTUend="FALSE" CDS 488314..488763 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" /EC_number="3.6.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576788, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NTP pyrophosphohydrolase" /protein_id="NP_388314.1" /db_xref="EnsemblGenomes-Gn:BSU04330" /db_xref="EnsemblGenomes-Tr:CAB12240" /db_xref="GOA:P96590" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11956" /db_xref="UniProtKB/Swiss-Prot:P96590" /translation="MYTQGAFVIVLNESQQILLVKRKDVPLWDLPGGRVDPGESAEEA AVREILEETGYNAALSAKIGVYQRPKFQDEQHLFFGSITGGQAMADGTETAGLKWVSP GRLPLFMVPNRKRQINDFKNGAQDVNVTVKDSGLLAAIDLLKRRLGK*" gene 488314..488763 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" promotor_-35 488776..488782 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 488797..488815 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 488798 /Source="Nicolas_upshifts" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" CDS 488830..490554 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" /EC_number="1.2.3.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291680, 16513748, 10220166, 23611909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-phosphate generating pyruvate oxidase" /protein_id="NP_388315.1" /db_xref="EnsemblGenomes-Gn:BSU04340" /db_xref="EnsemblGenomes-Tr:CAB12241" /db_xref="GOA:P96591" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12063" /db_xref="UniProtKB/Swiss-Prot:P96591" /translation="MAHKTAGQAMTELLEQWGVDHVYGIPGDSINEFIEELRHERNQL KFIQTRHEEVAALAAAAEAKLTGKIGVCLSIAGPGAVHLLNGLYDAKADGAPVLAIAG QVSSGEVGRDYFQEIKLEQMFEDVAVFNREVHSAESLPDLLNQAIRTAYSKKGVAVLS VSDDLFAEKIKREPVYTSPVYIEGNLEPKKEQLVTCAQYINNAKKPIILAGQGMKKAK RELLEFADKAAAPIVVTLPAKGVVPDKHPHFLGNLGQIGTKPAYEAMEECDLLIMLGT SFPYRDYLPDDTPAIQLDSDPAKIGKRYPVTAGLVCDSALGLRELTEYIERKEDRRFL NACTEHMQHWWNEIEKDETEATTPLKPQQVVARLQEAAADDAVLSVDVGTVTVWMARH FKMNANQDFIVSSWLATMGCGLPGAIAASLSEPERQAIAVCGDGGFSMVMQDLPTAVK YKLPITVVILNNENLGMIEYEQQVKGNIDYVTKLQNVDYAAFAESCGAKGIKVTKAEE LAPAFHEALHSDQPVVVDVMIGNEPPLPGKITYGQAKGFSKYMLKNFFENQKFEMPSL KKSLKRLF*" gene 488830..490554 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" S_feature complement(489666..490525) /Source="Nicolas_S_feature" /locus_tag="new_489666_490525_c" /HighExp="H2O2, Paraq, G180, G150, Oxctl, Diami, dia15, G135, C30, dia5" /AntisenseName="ydaP" /AntisenseCor="-5.0529608261635599E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S143" S_feature complement(490527..490638) /Source="Nicolas_S_feature" /locus_tag="new_490527_490638_c" /HighExp="dia5, M0t45, S0, S2, S1, Paraq, GM 120, Lbstat, MG 5, UNK1" /AntisenseName="ydaP" /AntisenseCor="1.7026698118644101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S144" downshifts 490538 /Source="Nicolas_upshifts" /id="D199" /incds=0 /nref=50 /ntot=166 /MaxReadThrough="5.18566" /MaxDrop="6.66568" /score="7.55338633" /energy="-5.3" /TU="U337" /idTUdmin="U336" /TUdmin=0 /isTUend="TRUE" CDS complement(490546..490749) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513943.1" /translation="MIRISMQGQMHLPLKQDAFVLLSVSSMAKSVPNTYTDHFMNSNM LKIHLFPKKKKKTRALRAPVFLK*" gene complement(490546..490749) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" downshifts complement(490570) /Source="Nicolas_upshifts" /id="D200" /incds=0 /nref=5 /ntot=55 /MaxReadThrough="4.75809" /MaxDrop="8.06239" /score="11.2659249" /energy="-9.1" /TU="U338,U340,U341" /idTUdmin="U338" /TUdmin="-110" /isTUend="FALSE" promotor_no_box complement(490598..490698) /Source="Nicolas_upshift_promotors" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 490607..490612 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 490629..490647 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(490638) /Source="Nicolas_upshifts" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" S_feature 490639..490854 /Source="Nicolas_S_feature" /locus_tag="new_490639_490854" /HighExp="Etha, S4, S8, S5, C30, S7, B60, S6, Salt, B36" /AntisenseName="ydzK" /AntisenseCor="3.8830946787094797E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigB" /TUshortPSig="0.914, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S145" upshifts 490639 /Source="Nicolas_upshifts" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" S_feature complement(490705..490776) /Source="Nicolas_S_feature" /locus_tag="new_490705_490776_c" /HighExp="Sw, B60, dia15, dia5, BI, Etha, BC, M9-stat, C90, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S146" downshifts complement(490748) /Source="Nicolas_upshifts" /id="D201" /incds=0 /nref=21 /ntot=191 /MaxReadThrough="5.39949" /MaxDrop="5.81865" /score="3.34912028" /energy="-20.3" /TU="U340,U341" /idTUdmin="U343" /TUdmin=0 /isTUend="TRUE" CDS complement(490777..491043) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_003097680.1" /db_xref="EnsemblGenomes-Gn:BSU04359" /db_xref="EnsemblGenomes-Tr:CAX52551" /db_xref="GOA:C0H3V4" /db_xref="UniProtKB/Swiss-Prot:C0H3V4" /translation="MSVFILFYLWIVPIVIGILCSVAAHKSKGKMRVAPGIAMIVLSI ISLITAFTAGHTNFHVFIGGMFLFGTFLVGSAFPFFFGLKKKEK*" gene complement(490777..491043) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" promotor_-10 complement(491059..491078) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(491077) /Source="Nicolas_upshifts" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" promotor_-35 complement(491090..491097) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(491147..492424) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton-coupled manganese transporter" /protein_id="NP_388317.1" /db_xref="EnsemblGenomes-Gn:BSU04360" /db_xref="EnsemblGenomes-Tr:CAB12243" /db_xref="GOA:P96593" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG12065" /db_xref="UniProtKB/Swiss-Prot:P96593" /translation="MMNKDITAQSPRSKAVQDALDGKIRGFRGLLPFLGPAFIAAIAY IDPGNFATNISAGSKYGYMLLWVILFSNIMALLIQSLSAKLGIATGKNLPEVAREEFP KPVSIGLWIQGELVIIATDLAEFIGAALGLYLLFGIPMLEASIIAAIGSFAILELQRR GYRSLEAGIAGMLFVVVIAFALQTFFAKPDAVSVMKGLFVPAFHGTDSVLLAAGILGA TVMPHAIYLHSALTQRRVVGKTDAERKKIFRFEFIDILIAMLIAGAINASMLIVAAAL FFKNGLFVEDLDVAFQQFGHLVSPMSAALFGIGLLVAGLSSSSVGTLSGDVIMQGFIN YRIPLYVRRFITIIPPILIIASGVNPTTALVLSQVVLSFGIAFALIPLIMFTSNKRIM GSLINAKWITVVSWLIAVLIVALNVFLIVDTFR*" gene complement(491147..492424) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" downshifts complement(491166) /Source="Nicolas_upshifts" /id="D202" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="5.8826" /MaxDrop="4.8109" /score="28.3182556" /energy="-9.6" /TU="U341,U343" /idTUdmin="U342" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(492486..492505) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(492498) /Source="Nicolas_upshifts" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" S_feature complement(492500..492577) /Source="Nicolas_S_feature" /locus_tag="new_492500_492577_c" /HighExp="S6, S8, S7, Etha, S5, Salt, BT, Heat, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB" /TUshortPSig="1, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S147" promotor_-35 complement(492518..492525) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(492561..492580) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(492577) /Source="Nicolas_upshifts" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" promotor_-35 complement(492594..492603) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(492654..492911) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388318.1" /db_xref="EnsemblGenomes-Gn:BSU04370" /db_xref="EnsemblGenomes-Tr:CAB12244" /db_xref="GOA:P96594" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG12066" /db_xref="UniProtKB/Swiss-Prot:P96594" /translation="MLSFLVSLVVAIVIGLIGSAIVGNRLPGGIFGSMIAGLIGAWIG HGLLGTWGPSLAGFAIFPAIIGAAIFVFLLGLIFRGLRKEA*" gene complement(492654..492911) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" downshifts complement(492662) /Source="Nicolas_upshifts" /id="D203" /incds=0 /nref=7 /ntot=33 /MaxReadThrough="4.70076" /MaxDrop="4.7213" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1496" /isTUend="FALSE" downshifts complement(492728) /Source="Nicolas_upshifts" /id="D204" /incds=1 /nref=2 /ntot=69 /MaxReadThrough="7.55545" /MaxDrop="2.8244" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1562" /isTUend="FALSE" CDS complement(492989..493441) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388319.1" /db_xref="EnsemblGenomes-Gn:BSU04380" /db_xref="EnsemblGenomes-Tr:CAB12245" /db_xref="InterPro:IPR018691" /db_xref="SubtiList:BG12067" /db_xref="UniProtKB/Swiss-Prot:P96595" /translation="MPWSMKDYPASLKNLEKPVRKKAIDIANAMIDEGYEEGRAIPIA TSKAKEWAENASTDEIDDFLTHDDETERDADPSSGSGPELMNKAEHVIKHKKGWAVKA EGAKRVSEIKDTKKEAIERAKEIAAHKGTEVIVHLADGSVQRKIKTGS*" gene complement(492989..493441) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" promotor_-10 complement(493460..493478) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(493477) /Source="Nicolas_upshifts" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" promotor_-35 complement(493492..493498) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 493510 /Source="Nicolas_upshifts" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" misc_feature 493518..493537 /Source="Nicolas_upshift_promotors" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 493559..494377 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388320.1" /db_xref="EnsemblGenomes-Gn:BSU04390" /db_xref="EnsemblGenomes-Tr:CAB12246" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG12068" /db_xref="UniProtKB/Swiss-Prot:P96596" /translation="MPTERKEDLHQQLKEIEKWEKDQQKVWFWEKLSRLPFQLLDKLT PEFIQKKIGKLLDEVGSFVQTGGQYLTSEKQIIRMFQKKLPEEIFESLEDIRKAPLPV MDEIAEGMGKNRTNAATVQGATTGVGGVFTLAADIPAVLGLSLKTLQDIAVAYGYDPK EKKERVFIVKCLQLTSADVVGKRSILQELKHYDQDRTYKNVASQIQGWREVVLGYRDT FGWKKLFQIVPVAGMVFGAAANRSTLNDITETGMMLYKKRRILERLKETEREME*" gene 493559..494377 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" downshifts 494368 /Source="Nicolas_upshifts" /id="D205" /incds=0 /nref=118 /ntot=223 /MaxReadThrough="0.66117" /MaxDrop="4.41502" /score="5.38936313" /energy="-9.2" /TU="NA" /idTUdmin="U344" /TUdmin=0 /isTUend="TRUE" promotor_-35 494445..494451 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 494465..494483 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 494473 /Source="Nicolas_upshifts" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" CDS 494506..494877 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651322, 9669336, 9763714, 12562800, 21421783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651322, 9669336, 9763714, 12562800, 21421783; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein glucose starvation induced" /protein_id="NP_388321.1" /db_xref="EnsemblGenomes-Gn:BSU04400" /db_xref="EnsemblGenomes-Tr:CAB12247" /db_xref="InterPro:IPR019626" /db_xref="SubtiList:BG10826" /db_xref="UniProtKB/Swiss-Prot:P26907" /translation="MADNNKMSREEAGRKGGETTSKNHDKEFYQEIGQKGGEATSKNH DKEFYQEIGEKGGEATSKNHDKEFYQEIGEKGGEATSENHDKEFYQEIGRKGGEATSK NHDKEFYQEIGSKGGNARNND*" gene 494506..494877 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" downshifts complement(494510) /Source="Nicolas_upshifts" /id="D206" /incds=0 /nref=1 /ntot=25 /MaxReadThrough="1.50212" /MaxDrop="4.6705" /score="-7.76438364" /energy="-14.2" /TU="NA" /idTUdmin="U346" /TUdmin=0 /isTUend="TRUE" downshifts 494894 /Source="Nicolas_upshifts" /id="D207" /incds=0 /nref=153 /ntot=219 /MaxReadThrough="3.75525" /MaxDrop="8.3301" /score="39.7307477" /energy="-16.6" /TU="U345" /idTUdmin="U345" /TUdmin="-24" /isTUend="FALSE" upshifts complement(494928) /Source="Nicolas_upshifts" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(494931..494934) /Source="Nicolas_upshift_promotors" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 494956..494963 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 494975..494994 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 494982 /Source="Nicolas_upshifts" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" CDS 495009..495350 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme; cupin family" /protein_id="NP_388322.1" /db_xref="EnsemblGenomes-Gn:BSU04410" /db_xref="EnsemblGenomes-Tr:CAB12248" /db_xref="GOA:P96597" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR019780" /db_xref="SubtiList:BG12069" /db_xref="UniProtKB/Swiss-Prot:P96597" /translation="MSKMQNLLAIANEVKEKHANFSISEVNDHCVRLAVFTGEYDWHH HPDSDELFIVLEGELLIDFKDKETAVLKANDSLLIPKGTVHRTRSYVRTVNLCVEHKQ AETVIIEEQPC*" gene 495009..495350 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" CDS 495344..495703 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388323.1" /db_xref="EnsemblGenomes-Gn:BSU04420" /db_xref="EnsemblGenomes-Tr:CAB12249" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR032555" /db_xref="SubtiList:BG12070" /db_xref="UniProtKB/Swiss-Prot:P96598" /translation="MLIKKMICEVDAANAEAFAKAQSQWEALSHISGFIKQAGGWRKT IDEPLTAEIISVWENREAYDHFMENEHDSIYEENDQKAVILSIEVTVYEEDKPFVHDL LHNPDIRYEPNWTVLKA*" gene 495344..495703 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" S_feature complement(495406..495699) /Source="Nicolas_S_feature" /locus_tag="new_495406_495699_c" /HighExp="Etha, Salt, M9-stat, C30, Heat, Sw, B60, S8, C90, UNK1" /AntisenseName="ydbC" /AntisenseCor="0.16172626521480701" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S148" downshifts 495644 /Source="Nicolas_upshifts" /id="D208" /incds=0 /nref=2 /ntot=130 /MaxReadThrough="1.8663" /MaxDrop="2.67081" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=0 /isTUend="TRUE" downshifts 495688 /Source="Nicolas_upshifts" /id="D209" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="0.252220000000001" /MaxDrop="2.61185" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=44 /isTUend="FALSE" CDS complement(495740..496561) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" /EC_number="1.11.1.6" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15231799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative manganese-containing catalase" /protein_id="NP_388324.1" /db_xref="EnsemblGenomes-Gn:BSU04430" /db_xref="EnsemblGenomes-Tr:CAB12250" /db_xref="GOA:P80878" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR027407" /db_xref="SubtiList:BG12071" /db_xref="UniProtKB/Swiss-Prot:P80878" /translation="MFKHTKMLQHPAKPDRPDPLFAKKMQEILGGQFGEISVAMQYLF QGWNTRGNEKYKDLLMDTATEELGHVEMIATMIARLLEDAPLDQQEKAAEDPVIGSIL GGMNPHHAIVSGLGAMPESSTGVPWSGGYIVASGNLLADFRANLNAESQGRLQVARLF EMTDDKGVKDMLSFLLARDTMHQNQWLAAIKELEAQEGPVVPGTFPKALEKQEFSHQL INFSEGEVSAEQNWLNEKAPDGEAFEYVKEAKTFGEKPELKPAPPFVHNTLPGRE*" gene complement(495740..496561) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" downshifts complement(495744) /Source="Nicolas_upshifts" /id="D210" /incds=0 /nref=62 /ntot=214 /MaxReadThrough="4.23505" /MaxDrop="6.82771" /score="-6.55917314" /energy="-13.1" /TU="U348" /idTUdmin="U348" /TUdmin="-310" /isTUend="FALSE" promotor_-10 complement(496583..496601) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(496604) /Source="Nicolas_upshifts" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" promotor_-35 complement(496615..496621) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(496646..497698) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:1809844, 10708364, 11566984, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1809844, 10708364, 11566984, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane bound C4-dicarboxylate binding sensor protein" /protein_id="NP_388325.1" /db_xref="EnsemblGenomes-Gn:BSU04440" /db_xref="EnsemblGenomes-Tr:CAB12251" /db_xref="GOA:P96600" /db_xref="InterPro:IPR004682" /db_xref="InterPro:IPR018389" /db_xref="SubtiList:BG12072" /db_xref="UniProtKB/Swiss-Prot:P96600" /translation="MKSLLACLALMIAGIATALFIGFHDHTGNKKIVYDDDQEGLQDQ IVFKFSHVVAENTPKGLAANKFADLVNEKSGGKIKIEVFPNGSLYSDIEEIEALQNGD VQFIAPSTSKLGMLSPEWGVLDLPYAFTDYNAVKKGLNGSIGTQLFDSLKKNQLKGLA YWTNGFKQITTNQGPVKTPDDLKGQDLRIMQSDVIEDQFKLLGATPHQESFNSTFQLL ENNVVDGEENTISNIYSKKFYNVQDYLTISSHGYLGYAVMTDEHFWKAQTPETRRILT EAMKETTEWNETYAEQMNKEQLEEIKKNSAIHIYELSDKEKQEWMKRLDPVYRQYEPI FGRELIRELLELRKDS*" gene complement(496646..497698) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" promotor_-35 496958..496965 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 496980..497767 /Source="Nicolas_S_feature" /locus_tag="new_496980_497767" /HighExp="LBGstat, Diami, T-0.40H, T0.0H, T0.30H, Heat, UNK1, GM-0.1, MG 90, Fru" /AntisenseName="dctB" /AntisenseCor="0.64205060306327899" /AntisenseRegPval="-31.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S149" promotor_-10 496980..496999 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 496981 /Source="Nicolas_upshifts" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" promotor_-10 complement(497711..497730) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(497716) /Source="Nicolas_upshifts" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" promotor_-35 complement(497744..497751) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 497768..499375 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388326.1" /db_xref="EnsemblGenomes-Gn:BSU04450" /db_xref="EnsemblGenomes-Tr:CAB12252" /db_xref="GOA:P96601" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12073" /db_xref="UniProtKB/Swiss-Prot:P96601" /translation="MNKKKLSIRWKITILSYILVIFSFLIGGIVLIGNIQHTEERELK KRLMNTARTVSEMTEVKEALARKKQTEAVRHAVEEIRMINEADYIVVMDMNHIRYTHP VSTSIGKKSEGADEEAAFAEHIYFSEAKGEIGTAVRAFYPVKDQDLNQIGVVLVGKTL PGIADILLHLKRDIAFIVVLTLGFGLAGSFLLARHIKKQMFQLEPHEIVRMYEERTAT FHSMNEGVIAIDNRLVITIFNEKAKQIFEVQGDLIGKVIWEVLKDSRLPEIVERNKAV YNEEIRVSGKVIMSSRIPIVMKKKVIGAVAIFQDRTEAAKMAEELTGVRNFVEALRVQ NHEHMNKLHTIAGLIQLGKSEKALQLAFQASTEQENVTEFLHRSIQNDAAAGLLLSKI RRGRELGIAVHIDENSSLQQFPEHVDQHDIVVLLGNLIENAFGSFETVQSEDKRIDIS IEQTDDILAILIEDNGCGIEPTHMPRLYDKGFTVNKTGGTGYGLYLVKQIIDKGSGTI EVDSHAGQGTSFSIVFPMKGEEAQHGS*" gene 497768..499375 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" CDS 499365..500045 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388327.1" /db_xref="EnsemblGenomes-Gn:BSU04460" /db_xref="EnsemblGenomes-Tr:CAB12253" /db_xref="GOA:P96602" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12074" /db_xref="UniProtKB/Swiss-Prot:P96602" /translation="MARKEWKVLLIEDDPMVQEVNKDFITTVKGVTVCATAGNGEEGM KLIKEEQPDLVILDVYMPKKDGIKTLQEIRKQKLEVDVIVVSAAKDKETISLMLQNGA VDYILKPFKLERMRQALEKYKQYKQKIEANDTLSQEQLDAILNIPQQAVQDLPKGLNH FTMNEVTAFLKQQTASLSAEEVAKALGIARVTARRYLDYLEKTGIIKLDVQYGGVGRP VNRYVLKG*" gene 499365..500045 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" S_feature 500046..500120 /Source="Nicolas_S_feature" /locus_tag="new_500046_500120" /HighExp="Sw, Diami, Mt0, G150, BI, Lbstat, M40t45, Lbtran, Mal, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S150" promotor_-35 500087..500094 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 500109..500126 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 500122 /Source="Nicolas_upshifts" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" CDS 500166..501431 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480; Product type t: transporter" /codon_start=1 /transl_table=11 /product="C4-dicarboxylate transport protein" /protein_id="NP_388328.1" /db_xref="EnsemblGenomes-Gn:BSU04470" /db_xref="EnsemblGenomes-Tr:CAB12254" /db_xref="GOA:P96603" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR023954" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12075" /db_xref="UniProtKB/Swiss-Prot:P96603" /translation="MKLFKNLTVQVITAVIIGVIVGLVWPDVGKEMKPLGDTFINAVK MVIAPIIFFTIVLGIAKMGDMKKVGKVGGKAFIYFEVVTTLALIIGLFVVNIMKPGAG LDYSKLEKGDVSQYTQNGGQGIDWIEFITHIVPSNMVDAFAKGDILQVLFFSILFGVG LAALGEKGKSVIDFFDKVSHVFFKIIGYIMRAAPIGAFGAMAYTIGHFGLDSIKPLAS LMMSVYITMFLFVFVALNIICKLYGFSLWNYLRFIKDELLIVLGTSSSESVLPRMMDK MERYGCSKSVVGLVIPTGYSFNLDGTSIYLSMATVFLAQVFGVDLSIGQQITIILVLM LTSKGAAGVTGSGFIVLASTLSALQVIPLEGLALLLGVDRFMSEGRAIVNLIGNGIAT IIVAKSENEFDEAKSIEAVEGMKKMKTAV*" gene 500166..501431 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" downshifts 501424 /Source="Nicolas_upshifts" /id="D211" /incds=0 /nref=175 /ntot=235 /MaxReadThrough="3.99042" /MaxDrop="7.04798" /score="45.0636559" /energy="-12.6" /TU="NA" /idTUdmin="U351" /TUdmin=0 /isTUend="TRUE" downshifts complement(501478) /Source="Nicolas_upshifts" /id="D212" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.588190000000001" /MaxDrop="3.06255" /score="19.3433396" /energy="-12.6" /TU="NA" /idTUdmin="U350" /TUdmin="-4818" /isTUend="FALSE" misc_feature 501515..501532 /Source="Nicolas_upshift_promotors" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 501517 /Source="Nicolas_upshifts" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" CDS 501579..502631 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388329.1" /db_xref="EnsemblGenomes-Gn:BSU04480" /db_xref="EnsemblGenomes-Tr:CAB12255" /db_xref="GOA:P96604" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG12076" /db_xref="UniProtKB/Swiss-Prot:P96604" /translation="MAALVKFFQHPGVRRFSIFVVLTGVLYLFKSMINLILLTFIFTF LMDRLELVVRQFVSQFFRVSQRVVITFLYMLLAVLLTVGGFVFYPVVAAQIQQLVKQI KHIAYHPDSIPFFDEITSVFGDINISSYVKEGFNVVYTYLADISTFGLQVVMALILSM FFLFEKKRLSEFMAKFKTSKLRVFYEEIAFFGSKFARTFGKVLEAQFIIALVNCILTF IALWIMHFPQLFGLSIMVFFLGLIPVAGVVISLIPLSIIAYSTGGGMYVLYIVLVIFA IHAIETYFLNPKLMSAKTELPIFFTFTVLIFSEHFFGIWGLIIGIPIFVFLLDILDVT NKEDRSKGPRENSDKK*" gene 501579..502631 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" S_feature 502632..502875 /Source="Nicolas_S_feature" /locus_tag="new_502632_502875" /HighExp="S8, S5, S6, LoTm, S7, S3, LBGstat, LBGexp, Paraq, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.87223499999999998" /TUshortSig="Sig-" /TUshortPSig="0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S151" downshifts 502832 /Source="Nicolas_upshifts" /id="D213" /incds=0 /nref=6 /ntot=45 /MaxReadThrough="6.05001" /MaxDrop="3.52626" /score="17.6400305" /energy="-12.4" /TU="U352" /idTUdmin="U351" /TUdmin=1408 /isTUend="FALSE" CDS 502908..503834 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding subunit)" /protein_id="NP_388330.1" /db_xref="EnsemblGenomes-Gn:BSU04490" /db_xref="EnsemblGenomes-Tr:CAB12256" /db_xref="GOA:P96605" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12077" /db_xref="UniProtKB/Swiss-Prot:P96605" /translation="MAEPILHIEGLDKKIGSKQILKQISMDVMEGEIIGLLGPNGSGK TTLIRIIVGLLKQNSGSVTISGFQHDTEFEKAMEAVGAIVENPEFYPYLTGWENLKHF ANMHKKIADERLDEVVERVGLTSAIHDKVKTYSLGMRQRLGIAQAILHRPKLLILDEP TNGLDPAGMKDFRDHIKELAEMEGTAVLFATHLLREVEDLCDRVIIIQKGEIKAEVSL QGTDQTTEKAIIEVQPQEKALNWLTGNQYQAESQDGTIVVEVAKENIPELNRSLVGQD LNVFSITPYTQSLEDEFIKATTAHQEEGEELV*" gene 502908..503834 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" CDS 503854..504594 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux ABC-transporter (permease subunit)" /protein_id="NP_388331.1" /db_xref="EnsemblGenomes-Gn:BSU04500" /db_xref="EnsemblGenomes-Tr:CAB12257" /db_xref="GOA:P96606" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12078" /db_xref="UniProtKB/Swiss-Prot:P96606" /translation="MKLFNRKVTLVSLILMAVFQFFMALIIKRIVISAGTDENFIGYL SYTPSLNILLQALTIVIAATIVSMEFDKKTIKFLLIRPVKRQKVFWSKLITVVMVSFY LYLAYYILALLFGLLFFGTSVTAESKTLLVNTLALIGSNWLEAVMMGLFGLLCSSLFR NSAVAVVVSFVVLYGASTLVQLMKLFENKWGSFLLFANTDFTQYRSGETALFSGMTPL FSIGILIIHAIFFIVVGWWCFCKRDVRV*" gene 503854..504594 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" misc_feature 504653..504672 /Source="Nicolas_upshift_promotors" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 504658 /Source="Nicolas_upshifts" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" CDS 504689..505024 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17928292; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative glyco-prenyl flippase subunit" /protein_id="NP_388332.1" /db_xref="EnsemblGenomes-Gn:BSU04510" /db_xref="EnsemblGenomes-Tr:CAB12258" /db_xref="GOA:P96607" /db_xref="SubtiList:BG12079" /db_xref="UniProtKB/Swiss-Prot:P96607" /translation="MRNFITALPIVLLLGFSFVSFMFQFEHLVYFRLALGLFSLVGLY MIYKMKTGIRYFIIYLYASWIVLAAVTAFEEPIFSSFFFGGLVMTMGYLTYMLIYLGM KQDRDANPV*" gene 504689..505024 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" downshifts 504999 /Source="Nicolas_upshifts" /id="D214" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="5.33473" /MaxDrop="5.39081" /score="25.8152101" /energy="-18.4" /TU="U352,U353" /idTUdmin="U352" /TUdmin="-1177" /isTUend="FALSE" S_feature 505044..505113 /Source="Nicolas_S_feature" /locus_tag="new_505044_505113" /HighExp="ferm, nit, S2, S0, Gly, M0t45, M0t90, Lbstat, M/G, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.99, 0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S152" promotor_-35 505079..505086 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 505100..505119 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 505114 /Source="Nicolas_upshifts" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" CDS 505152..506297 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA dehydrogenase" /protein_id="NP_388333.1" /db_xref="EnsemblGenomes-Gn:BSU04520" /db_xref="EnsemblGenomes-Tr:CAB12259" /db_xref="GOA:P96608" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013107" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG12080" /db_xref="UniProtKB/Swiss-Prot:P96608" /translation="MSLFIQNDQQRQWMEKIGRIADEFQQTAAEDDEQGRFPAEKIQK LRDAGYTALTLPASHGGGGISVYDMLLFQERLARGDAPTALSIGWHLSVIGELGEGNS WDEDVFAFVAKEVQNGAVINRAATEAKTGSPTRGGRPGTHAVKKDGKWAVNGRKTFTT MSQALDYFLVTAWIEDKQTTGVFLIHKDDPGLSIEETWDMMAMRATGSHDLVLNEVML DENKLVELLQGPRGAKPNGWLLHIPAIYLGVAQAARDYAVQFASEYSPNSLNGPIKNV PAVQQRTGEMELELLNARHFLFHIAQLYDDPVRRPHLTSELGAAKHIVTNAALSVVDK AMRIVGAKSLERTNPLQRYYRDVRAGLHNPPMDDAVIHKLAAEAFES*" gene 505152..506297 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" downshifts 506279 /Source="Nicolas_upshifts" /id="D215" /incds=0 /nref=13 /ntot=123 /MaxReadThrough="2.90782" /MaxDrop="4.20573" /score="9.48525091" /energy="-7" /TU="NA" /idTUdmin="U353" /TUdmin="-7" /isTUend="TRUE" CDS complement(506322..506501) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" /experiment="publication(s) with functional evidences, PMID:12354229, 16428414, 18697947, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16428414, 18697947, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="NP_388334.1" /db_xref="EnsemblGenomes-Gn:BSU04530" /db_xref="EnsemblGenomes-Tr:CAB12260" /db_xref="GOA:P96609" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG12081" /db_xref="UniProtKB/Swiss-Prot:P96609" /translation="MNTNMSGGRRSMPKRKVKTYQQLIQENKEAIMGNPKLMNVIYDR IDRKHQKNLQEQNNT*" gene complement(506322..506501) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" downshifts complement(506340) /Source="Nicolas_upshifts" /id="D216" /incds=0 /nref=158 /ntot=207 /MaxReadThrough="2.35872" /MaxDrop="6.38199" /score="26.3317207" /energy="-7" /TU="NA" /idTUdmin="U355" /TUdmin=0 /isTUend="TRUE" CDS complement(506455..506619) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513944.1" /db_xref="EnsemblGenomes-Gn:BSU04536" /db_xref="EnsemblGenomes-Tr:CCQ48594" /db_xref="InterPro:IPR025072" /db_xref="UniProtKB/TrEMBL:L8ECQ9" /translation="MTPQSAEIRKKQLIHLLIQNGIYKKSKRHLYELSLTELESEYKH VRRAPEHAEA*" gene complement(506455..506619) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" S_feature complement(506502..506670) /Source="Nicolas_S_feature" /locus_tag="new_506502_506670_c" /HighExp="B60, nit, B36, Lbexp, GM 15, GM 10, dia0, S2, GM 25, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99141199999999996" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S153" promotor_-10 complement(506662..506681) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(506672) /Source="Nicolas_upshifts" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" promotor_-35 complement(506696..506703) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 506811..506816 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 506832..506850 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 506836 /Source="Nicolas_upshifts" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" CDS 506866..507738 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cation efflux system" /protein_id="NP_388335.1" /db_xref="EnsemblGenomes-Gn:BSU04540" /db_xref="EnsemblGenomes-Tr:CAB12261" /db_xref="GOA:P96610" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12082" /db_xref="UniProtKB/Swiss-Prot:P96610" /translation="MERTENLKKGEKGALLNIFAYVILAVVKLVIGILYHSEALRADG LNNGTDIVASVAVLIGLRISQRPADSDHPYGHYRAETISSLVASFIMMAVGIEVLIGG GKAIAGGTTETPNLIAAWTALGSAVFMYGIYLYNKRLAASIKSSALMAAAKDSRSDAF VSAGAFIGVFSSQLKLPWVDPVTAFIIGIIICKTAWDIFKDASHSLTDGFHLKDLEPY KQTVGRIENVHRLKDVKARYLGSTVHIEMVITVDPKLTVEEGHGVADEVEDKIKHEHD VTHVHVHVEPDDIK*" gene 506866..507738 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" promotor_-35 507102..507111 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 507124..507139 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 507127 /Source="Nicolas_upshifts" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" S_feature complement(507683..507752) /Source="Nicolas_S_feature" /locus_tag="new_507683_507752_c" /HighExp="LPhT, dia15, dia5, Diami, Etha, Lbtran, LBGtran, LBGstat, Mt0, M0t45" /AntisenseName="ydbO" /AntisenseCor="0.18463882527998399" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S154" downshifts complement(507726) /Source="Nicolas_upshifts" /id="D217" /incds=0 /nref=145 /ntot=242 /MaxReadThrough="3.07579" /MaxDrop="6.00116" /score="9.69023537" /energy="-12.3" /TU="U359" /idTUdmin="U359" /TUdmin="-198" /isTUend="FALSE" S_feature 507739..508088 /Source="Nicolas_S_feature" /locus_tag="new_507739_508088" /HighExp="Salt, Paraq, G135, ferm, Oxctl, T-0.40H, G150, Lbexp, T3.0H, T2.30H" /AntisenseName="ydbP" /AntisenseCor="-0.27800721625230801" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S155" CDS complement(507753..508073) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388336.1" /db_xref="EnsemblGenomes-Gn:BSU04550" /db_xref="EnsemblGenomes-Tr:CAB12262" /db_xref="GOA:P96611" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12083" /db_xref="UniProtKB/Swiss-Prot:P96611" /translation="MKKITTNEQFNELIQSDKEIIVKFYADWCPDCTRMNMFIGDILE EYNQNDWYELNKDELPDLAEKYQVMGIPSLLIFKNGEKTAHLHSANAKTPEEVTEFLS EHIS*" gene complement(507753..508073) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" promotor_-35 508069..508073 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 508082..508096 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 508090..508247 /Source="Nicolas_S_feature" /locus_tag="new_508090_508247" /HighExp="Lbexp, dia0, LBGexp, H2O2, Paraq, Oxctl, G180, Salt, M0t45, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigWXY" /TUshortPSig="0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S156" upshifts 508090 /Source="Nicolas_upshifts" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" promotor_-10 complement(508094..508113) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(508109) /Source="Nicolas_upshifts" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" promotor_-35 complement(508127..508134) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-35" CDS 508248..509312 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" /EC_number="6.3.2.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8662022, 12682299, 22407814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine ligase A" /protein_id="NP_388337.1" /db_xref="EnsemblGenomes-Gn:BSU04560" /db_xref="EnsemblGenomes-Tr:CAB12263" /db_xref="GOA:P96612" /db_xref="InterPro:IPR000291" /db_xref="InterPro:IPR005905" /db_xref="InterPro:IPR011095" /db_xref="InterPro:IPR011127" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11932" /db_xref="UniProtKB/Swiss-Prot:P96612" /translation="MYGGKSAEHNVSLQTALAVIKALNTEKFDIHPIYITEKGEWVRG ARLTEPVSNVKMLQFEQGGSAFSPAALNQEMFPQEASQQNEAIDVVFPLLHGPNGEDG TIQGMLELLNIPYVGNGVLASSAGMDKVVMKHLFAQVGLAQAKYAAFLKKDWTRSPKE SCEEVEQELGYPCFVKPANLGSSVGISKCRNREELQKAFELAFQYDRKVVVEEGINGR EIEIGVLGNDDPKCSVVGEIAPKTDFYDYKAKYEDGDTDLMIPAIVTDEEYATISDMA IKAFKAIDGSGLVRADFFLTADGEVLINEVNTMPGFTPFSMFPLLWKEAGVEYADLIE QLVELAKERHAEKQLIKHTF*" gene 508248..509312 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" downshifts 509300 /Source="Nicolas_upshifts" /id="D218" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="5.68418" /MaxDrop="2.53103" /score="3.92144467" /energy="-9.6" /TU="U357,U358" /idTUdmin="U356" /TUdmin=2310 /isTUend="FALSE" CDS 509384..510757 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" /EC_number="6.3.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-D-alanyl-D-alanine ligase" /protein_id="NP_388338.1" /db_xref="EnsemblGenomes-Gn:BSU04570" /db_xref="EnsemblGenomes-Tr:CAB12264" /db_xref="GOA:P96613" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005863" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG12084" /db_xref="UniProtKB/Swiss-Prot:P96613" /translation="MIKRTVKNIAEMVKGTLANPQYEQTVIHGVATDTRKLEQHQLFI PLKGERFDGHSFVEQAFEAGVAAVLWDRSVPNPPENHAVILVDDTLTALQQLAKAYLQ ELGTRVIGVTGSNGKTTTKDMIHAVLGTQYRVHKTGGNFNNHIGLPLTVLAMPENTEI AVLEMGMSAKGEIDLLSRLANPDAAVITNIGESHMQDLGSREGIAEAKLEIINGLKED GVLIYIGDEPLLQNAYSCQTKTYGTGTHNDYQLQDVSQSEEGTHFTIKGIENTFFIPI LGKHNVMNAMAAIAAGAYFGIAPEDAAKGLSGLKVTGMRLELIKTDSGLSIINDAYNA SPTSMKAAIQLTESLEGYGKKMLVLGDMLELGDLEETFHKECGAVISPDKIDRVFTYG KLGAFIAEGALKHFEKDRVSHYTEKKDLLQAVKENASKGDLILFKASRGMKLEEIVKD LIESPLS*" gene 509384..510757 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" promotor_-35 510788..510794 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 510808..510819 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 510818 /Source="Nicolas_upshifts" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" misc_feature 510861..510880 /Source="Nicolas_upshift_promotors" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 510862..511036 /Source="Nicolas_S_feature" /locus_tag="new_510862_511036" /HighExp="Cold, ferm, nit, G135, S5, LBGexp, G150, S8, S7, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.76694499999999999" /TUshortSig="SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S157" upshifts 510862 /Source="Nicolas_upshifts" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" promotor_-35 511004..511011 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 511026..511045 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 511038..511105 /Source="Nicolas_S_feature" /locus_tag="new_511038_511105" /HighExp="Cold, G150, T-3.40H, HPh, Salt, LPh, G180, G135, Oxctl, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S158" upshifts 511038 /Source="Nicolas_upshifts" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" CDS 511157..512641 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16352840, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352840, 27965645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_388339.2" /db_xref="EnsemblGenomes-Gn:BSU04580" /db_xref="EnsemblGenomes-Tr:CAB12265" /db_xref="GOA:P96614" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030880" /db_xref="SubtiList:BG12085" /db_xref="UniProtKB/Swiss-Prot:P96614" /translation="MTITFQDFNLSSDLMKAINRMGFEEATPIQAQTIPLGLSNKDVI GQAQTGTGKTAAFGIPLVEKINPESPNIQAIVIAPTRELAIQVSEELYKIGQDKRAKV LPIYGGQDIGRQIRALKKNPNIIVGTPGRLLDHINRRTIRLNNVNTVVMDEADEMLNM GFIDDIESILSNVPSEHQTLLFSATMPAPIKRIAERFMTEPEHVKVKAKEMTVSNIQQ FYLEVQERKKFDTLTRLLDIQSPELAIVFGRTKRRVDELAEALNLRGYAAEGIHGDLT QAKRMVALRKFKEGAIEVLVATDVAARGLDISGVTHVYNFDVPQDPESYVHRIGRTGR AGKTGMAMTFITPREKSMLRAIEQTTKRKMDRMKEPTLDEALEGQQQVTVERLRTTIS ENNLNFYMTAAAELLEDHDAVTVVAAAIKMATKEPDDTPVRLTDEAPMVSKRYKNQRS SKRRDGQGGGYRGGKGKSNNRSSYDKKRSNDRRSSGDRRQKKSY*" gene 511157..512641 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" downshifts 512634 /Source="Nicolas_upshifts" /id="D219" /incds=0 /nref=309 /ntot=313 /MaxReadThrough="1.91428" /MaxDrop="8.13079" /score="26.104757" /energy="-13.1" /TU="NA" /idTUdmin="U358" /TUdmin="-10" /isTUend="TRUE" S_feature 512754..512813 /Source="Nicolas_S_feature" /locus_tag="new_512754_512813" /HighExp="Etha, LBGexp, G180, Cold, Lbtran, dia0, G150, BMM, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S159" promotor_-35 512754..512763 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 512756 /Source="Nicolas_upshifts" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" promotor_-10 512775..512790 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 512814..513293 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388340.1" /db_xref="EnsemblGenomes-Gn:BSU04590" /db_xref="EnsemblGenomes-Tr:CAB12266" /db_xref="GOA:P96615" /db_xref="InterPro:IPR005182" /db_xref="SubtiList:BG12086" /db_xref="UniProtKB/Swiss-Prot:P96615" /translation="MREQPKNQISPDGLKVWRLQEIIISAVCLLIVIAVAVLSYYFHW PYWISGVLGAVWLLGSIVTVFIIPKVRHKVWRYEVHEHEIDIQSGIFVVTRVIVPMVR VQHVDTSQGPLLKKYNLATVKISTAATVHSIPALEMEEADRLRDSISRLARVTDDDV* " gene 512814..513293 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" CDS 513283..514764 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388341.1" /db_xref="EnsemblGenomes-Gn:BSU04600" /db_xref="EnsemblGenomes-Tr:CAB12267" /db_xref="GOA:P96616" /db_xref="InterPro:IPR005182" /db_xref="InterPro:IPR014529" /db_xref="SubtiList:BG12087" /db_xref="UniProtKB/Swiss-Prot:P96616" /translation="MMSEPKRLHPVAVILNLCHTIIQTIKNIILPFFFVYIVNSNHTV RFYGAIALGVLFIWLVAASIIKWRRFTYRIEDDEFRIEEGLFVTKKRYISIDRIQTMN TSAGLVQQIFKLVKLQIETAGGGKEAEAVLSAISVEEAERIKEAVFKKKAQRRENELD EERLEAEEELDPSVEVQEHYRMNAKELLMAASTSGGIGVIISAVFALISQLDEVLPMD WLFDKFSFLQHASIGIYAVLIFIGLFIAWIFSIAGMMFRYANFQIIKKEQELVISRGI IEKHQVTIPLRKIQAIKIKENIIRQLFGFVTVSIVSAGGGDREKEEGALTILFPMIHK KKLPHMLRTFTPEYTLEENCRRLPRRALKRYLFRSVIFSLFLIIPLCIFFQPWGYLSV ILLPIELLFGYLAYKEAAWTINGDRLQLTSRFIGRTTAIVLKKRMQVCKFSQSYFQKK GRLYTISTSVKSSSHMEELTVRDVGEEDAAFILKWYSYEKADG*" gene 513283..514764 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" downshifts 514734 /Source="Nicolas_upshifts" /id="D220" /incds=0 /nref=6 /ntot=162 /MaxReadThrough="4.90913" /MaxDrop="3.0931" /score="48.2239319" /energy="-17.1" /TU="U363" /idTUdmin="U364" /TUdmin="-638" /isTUend="FALSE" S_feature 514779..515106 /Source="Nicolas_S_feature" /locus_tag="new_514779_515106" /HighExp="Salt, T0.30H, G135, T1.0H, T1.30H, G150, G180, Oxctl, T-0.40H, aero" /AntisenseName="ydcA" /AntisenseCor="-0.25636523135066602" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S160" downshifts complement(514788) /Source="Nicolas_upshifts" /id="D221" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="0.258529999999999" /MaxDrop="3.15455" /score="-3.74867023" /energy="-8.8" /TU="NA" /idTUdmin="U365" /TUdmin=220 /isTUend="FALSE" CDS complement(515016..515615) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" /EC_number="3.4.21.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15616571, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative rhomboid protease" /protein_id="NP_388342.1" /db_xref="EnsemblGenomes-Gn:BSU04610" /db_xref="EnsemblGenomes-Tr:CAB12268" /db_xref="GOA:P96617" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG12088" /db_xref="UniProtKB/Swiss-Prot:P96617" /translation="MFIRTENFQTFIRLYPVVTFILALQAVLWLFFSLPAHSVVLWRD TVTGYNLGVANGEWWRLITPILLHAGFTHLLFNSMSIFLFAPALERMLGKARFLLVYA GSGIIGNIGTYVTEPLDYVHVGASGAIFGLFGVYLFMVLFRNELIGQEHSKMIITLLA FAVLMSFINSNINMMAHLFGLCGGFLLSFLCVQKKERRY*" gene complement(515016..515615) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" promotor_-35 515076..515081 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 515094..515113 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 515108..515709 /Source="Nicolas_S_feature" /locus_tag="new_515108_515709" /HighExp="Salt, G135, G150, T0.30H, G180, T1.0H, T1.30H, H2O2, Paraq, Oxctl" /AntisenseName="ydcA" /AntisenseCor="-0.11975373672841701" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S161" upshifts 515108 /Source="Nicolas_upshifts" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" misc_feature complement(515639..515658) /Source="Nicolas_upshift_promotors" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(515650) /Source="Nicolas_upshifts" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" CDS 515710..516075 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" /EC_number="2.7.8.7" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11489886, 11525165, 11867633, 12682299, 12926246, 15955059, 16597923; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="holo-acyl carrier protein synthase (phosphopantetheinyl transferase)" /protein_id="NP_388343.1" /db_xref="EnsemblGenomes-Gn:BSU04620" /db_xref="EnsemblGenomes-Tr:CAB12269" /db_xref="GOA:P96618" /db_xref="InterPro:IPR002582" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1F7L" /db_xref="PDB:1F7T" /db_xref="PDB:1F80" /db_xref="SubtiList:BG12089" /db_xref="UniProtKB/Swiss-Prot:P96618" /translation="MIYGIGLDITELKRIASMAGRQKRFAERILTRSELDQYYELSEK RKNEFLAGRFAAKEAFSKAFGTGIGRQLSFQDIEIRKDQNGKPYIICTKLSQAAVHVS ITHTKEYAAAQVVIERLSS*" gene 515710..516075 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" promotor_-35 516078..516083 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-35" S_feature 516099..516240 /Source="Nicolas_S_feature" /locus_tag="new_516099_516240" /HighExp="S3, S4, BT, LoTm, S5, T5.0H, M9-stat, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S162" promotor_-10 516099..516117 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-10" upshifts 516099 /Source="Nicolas_upshifts" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" CDS 516241..517257 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388344.2" /db_xref="EnsemblGenomes-Gn:BSU04630" /db_xref="EnsemblGenomes-Tr:CAB12270" /db_xref="GOA:P96619" /db_xref="InterPro:IPR029046" /db_xref="SubtiList:BG12090" /db_xref="UniProtKB/Swiss-Prot:P96619" /translation="MKKVRKSFVLLLTGLLAVLILSACGQKTQQDIVAGLDEKAKEYT SYKAKAKMTIETGSEPQVYNVEIWHKKPSLYRVYLENPKKDQNQVILRNENGVFVLTP SLNKSFRFQSDWPNNSSQVYLFESLVKDVQNDSDAVFTAKEKKYVFETKTNYQHNKML PTQEITFNKKDMSPSSVKVMDTDRKVMVKVEFSSFEFNKQFDKESFDEKKNMTLSQMD VATSAKPSDTFAVKTPLELPLGVKLLEEKDISTEDGKRIIMTYGGEKSFTLIQEKAQI AKASSSVTLNGEPVNLGYTIGALSDASLSWTYDGVDYLLSSKDLSKEEMVTVAKSMQG QSSK*" gene 516241..517257 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" downshifts 517242 /Source="Nicolas_upshifts" /id="D222" /incds=0 /nref=193 /ntot=256 /MaxReadThrough="3.39815" /MaxDrop="6.13946" /score="22.0391647" /energy="-9.5" /TU="U366" /idTUdmin="U363" /TUdmin=0 /isTUend="TRUE" promotor_-35 517302..517309 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 517323..517342 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 517330 /Source="Nicolas_upshifts" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" CDS 517372..518541 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" /EC_number="5.1.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2835089, 12682299, 15043879, 18399999, 25227915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine racemase" /protein_id="NP_388345.1" /db_xref="EnsemblGenomes-Gn:BSU04640" /db_xref="EnsemblGenomes-Tr:CAB12271" /db_xref="GOA:P10725" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10950" /db_xref="UniProtKB/Swiss-Prot:P10725" /translation="MSTKPFYRDTWAEIDLSAIKENVSNMKKHIGEHVHLMAVVKANA YGHGDAETAKAALDAGASCLAVAILDEAISLRKKGLKAPILVLGAVPPEYVAIAAEYD VTLTGYSVEWLQEAARHTKKGSLHFHLKVDTGMNRLGVKTEEEVQNVMAILDRNPRLK CKGVFTHFATADEKERGYFLMQFERFKELIAPLPLKNLMVHCANSAAGLRLKKGFFNA VRFGIGMYGLRPSADMSDEIPFQLRPAFTLHSTLSHVKLIRKGESVSYGAEYTAEKDT WIGTVPVGYADGWLRKLKGTDILVKGKRLKIAGRICMDQFMVELDQEYPPGTKVTLIG RQGDEYISMDEIAGRLETINYEVACTISSRVPRMFLENGSIMEVRNPLLQVNISN*" gene 517372..518541 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" promotor_-35 518470..518475 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 518490..518508 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 518496 /Source="Nicolas_upshifts" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" promotor_-35 518571..518574 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 518590..518609 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 518591 /Source="Nicolas_upshifts" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" CDS 518657..518938 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antitoxin EndoAI" /protein_id="NP_388346.1" /db_xref="EnsemblGenomes-Gn:BSU04650" /db_xref="EnsemblGenomes-Tr:CAB12272" /db_xref="GOA:P96621" /db_xref="InterPro:IPR002145" /db_xref="InterPro:IPR010985" /db_xref="InterPro:IPR013321" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12091" /db_xref="UniProtKB/Swiss-Prot:P96621" /translation="MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAY VSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAECEAETTVERLVSGG*" gene 518657..518938 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" CDS 518943..519293 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 21897862, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 21897862, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease toxin" /protein_id="NP_388347.1" /db_xref="EnsemblGenomes-Gn:BSU04660" /db_xref="EnsemblGenomes-Tr:CAB12273" /db_xref="GOA:P96622" /db_xref="InterPro:IPR003477" /db_xref="InterPro:IPR011067" /db_xref="PDB:1NE8" /db_xref="PDB:4MDX" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12092" /db_xref="UniProtKB/Swiss-Prot:P96622" /translation="MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIV AAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQIRTIDKQRLTDKITHLDDEMMDK VDEALQISLALIDF*" gene 518943..519293 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" S_feature complement(519083..519559) /Source="Nicolas_S_feature" /locus_tag="new_519083_519559_c" /HighExp="Etha, Gly, Sw, S8, C30, S6, LBGstat, T0.30H, S7, Salt" /AntisenseName="ndoA" /AntisenseCor="-0.36117231948253697" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigK" /TUshortPSig="1, 1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S163" downshifts complement(519126) /Source="Nicolas_upshifts" /id="D223" /incds=1 /nref=6 /ntot=171 /MaxReadThrough="3.51096" /MaxDrop="3.79912" /score="-8.86444162" /energy="-10.2" /TU="U372" /idTUdmin="U371" /TUdmin="-4" /isTUend="TRUE" downshifts 519273 /Source="Nicolas_upshifts" /id="D224" /incds=0 /nref=143 /ntot=254 /MaxReadThrough="5.57908" /MaxDrop="5.74865" /score="29.7721113" /energy="-8.9" /TU="U367,U368,U369" /idTUdmin="U366" /TUdmin=799 /isTUend="FALSE" promotor_-35 519327..519334 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 519348..519367 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 519356 /Source="Nicolas_upshifts" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" CDS 519408..520232 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome); positive regulation of sigma(B) activity in response to salt and heat stress" /protein_id="NP_388348.1" /db_xref="EnsemblGenomes-Gn:BSU04670" /db_xref="EnsemblGenomes-Tr:CAB12274" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR014792" /db_xref="InterPro:IPR036513" /db_xref="PDB:2BNL" /db_xref="SubtiList:BG11090" /db_xref="UniProtKB/Swiss-Prot:P42409" /translation="MMSNQTVYQFIAENQNELLQLWTDTLKELSEQESYQLTDQVYEN ISKEYIDILLLSVKDENAAESQISELALRAVQIGLSMKFLATALAEFWKRLYTKMNDK RLPDQESTELIWQIDRFFSPINTEIFNQYSISWEKTVSLQKIALQELSAPLIPVFENI TVMPLVGTIDTERAKRIMENLLNGVVKHRSQVVLIDITGVPVVDTMVAHHIIQASEAV RLVGAKCLLAGIRPEIAQTIVNLGIDLSQVITKNTLQKGIQTALEMTDRKIVSLGE*" gene 519408..520232 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" promotor_-10 complement(519542..519560) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(519559) /Source="Nicolas_upshifts" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" S_feature complement(519561..520160) /Source="Nicolas_S_feature" /locus_tag="new_519561_520160_c" /HighExp="Etha, Sw, Gly, S6, S8, S7, B60, Salt, BT, M9-stat" /AntisenseName="rsbRA" /AntisenseCor="-0.53924606340364201" /AntisenseRegPval="-21" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S164" promotor_-35 complement(519574..519581) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(520149..520167) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(520160) /Source="Nicolas_upshifts" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" S_feature complement(520162..520750) /Source="Nicolas_S_feature" /locus_tag="new_520162_520750_c" /HighExp="S6, S8, S7, BT, C30, S5, G135, C90, Gly, Fru" /AntisenseName="rsbS" /AntisenseCor="-0.57706416777859804" /AntisenseRegPval="-24.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S165" promotor_-35 complement(520181..520187) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 520237..520602 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 23320651, 28271471; Product type f : factor" /codon_start=1 /transl_table=11 /product="antagonist of RsbT" /protein_id="NP_388349.1" /db_xref="EnsemblGenomes-Gn:BSU04680" /db_xref="EnsemblGenomes-Tr:CAB12275" /db_xref="GOA:P42410" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11091" /db_xref="UniProtKB/Swiss-Prot:P42410" /translation="MRHPKIPILKLYNCLLVSIQWELDDQTALTFQEDLLNKIYETGA NGVVIDLTSVDMIDSFIAKVLGDVITMSKLMGAKVVLTGIQPAVAVTLIELGIALEEI ETALDLEQGLETLKRELGE*" gene 520237..520602 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" CDS 520606..521007 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine-threonine kinase; controlsthe activity of the anxiosome (stressosome)" /protein_id="NP_388350.1" /db_xref="EnsemblGenomes-Gn:BSU04690" /db_xref="EnsemblGenomes-Tr:CAB12276" /db_xref="GOA:P42411" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11092" /db_xref="UniProtKB/Swiss-Prot:P42411" /translation="MNDQSCVRIMTEWDIVAARQLGRNVAKELGFGTVDQARITTAIS ELARNIYLYAGKGQIGIEQVADRGKKGLKIIAEDQGPGIPDIRKVMEDGFSTSGGLGA GLPGVKRLMDEFSLNSVAGEGTEIQAIKWLR*" gene 520606..521007 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" promotor_-10 complement(520748..520767) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(520765) /Source="Nicolas_upshifts" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" promotor_-35 complement(520781..520790) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 521019..522026 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 17303566, 21979936, 28461450" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 17303566, 21979936, 28461450; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine phosphatase; controls the activity of the anxiosome (stressosome)" /protein_id="NP_388351.1" /db_xref="EnsemblGenomes-Gn:BSU04700" /db_xref="EnsemblGenomes-Tr:CAB12277" /db_xref="GOA:P40399" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014787" /db_xref="InterPro:IPR017944" /db_xref="InterPro:IPR036457" /db_xref="PDB:1W53" /db_xref="PDB:2J6Y" /db_xref="PDB:2J6Z" /db_xref="PDB:2J70" /db_xref="SubtiList:BG11057" /db_xref="UniProtKB/Swiss-Prot:P40399" /translation="MDFREVIEQRYHQLLSRYIAELTETSLYQAQKFSRKTIEHQIPP EEIISIHRKVLKELYPSLPEDVFHSLDFLIEVMIGYGMAYQEHQTLRGIQQEIKSEIE IAANVQQTLLGTKVPQEEALDIGAISVPAKQMSGDYYHFVKDKESINIAIADVIGKGI PAALCMSMIKYAMDSLPETGIHPSQVLKNLNRVVEQNVDASMFITMFYANYNMDKHQF TYASAGHEPGFYYSQKDNTFYDLEAKGLVLGISQDYDYKQFDQHLEKGDMIVLFSDGV TECRTENGFLERPDLQKLIEEHMCSSAQEMVKNIYDSLLKLQDFQLHDDFTLIVLRRK V*" gene 521019..522026 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" promotor_-35 522020..522026 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 522041..522059 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 522047 /Source="Nicolas_upshifts" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" CDS 522088..522417 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677; Product type f: factor" /codon_start=1 /transl_table=11 /product="anti-anti-sigma factor (antagonist of RsbW)" /protein_id="NP_388352.1" /db_xref="EnsemblGenomes-Gn:BSU04710" /db_xref="EnsemblGenomes-Tr:CAB12278" /db_xref="GOA:P17903" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR003658" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG10733" /db_xref="UniProtKB/Swiss-Prot:P17903" /translation="MNINVDVKQNENDIQVNIAGEIDVYSAPVLREKLVPLAEQGADL RICLKDVSYMDSTGLGVFVGTFKMVKKQGGSLKLENLSERLIRLFDITGLKDIIDISA KSEGGVQ*" gene 522088..522417 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" CDS 522414..522896 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 21979936, 27977677; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine kinase and anti-sigma factor (inhibitory sigma-B binding protein)" /protein_id="NP_388353.1" /db_xref="EnsemblGenomes-Gn:BSU04720" /db_xref="EnsemblGenomes-Tr:CAB12279" /db_xref="GOA:P17904" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010193" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10734" /db_xref="UniProtKB/Swiss-Prot:P17904" /translation="MKNNADYIEMKVPAQPEYVGIIRLTLSGVASRMGYTYDEIEDLK IAVSEACTNAVQHAYKEDKNGEVSIRFGVFEDRLEVIVADEGDSFDFDQKQQDLGPYT PSHTVDQLSEGGLGLYLMETLMDEVRVQNHSGVTVAMTKYLNGERVDHDTTIKNYETN *" gene 522414..522896 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" CDS 522862..523650 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-37 factor (sigma(B))" /protein_id="NP_388354.2" /db_xref="EnsemblGenomes-Gn:BSU04730" /db_xref="EnsemblGenomes-Tr:CAB12280" /db_xref="GOA:P06574" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014288" /db_xref="InterPro:IPR014322" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10735" /db_xref="UniProtKB/Swiss-Prot:P06574" /translation="MTQPSKTTKLTKDEVDRLISDYQTKQDEQAQETLVRVYTNLVDM LAKKYSKGKSFHEDLRQVGMIGLLGAIKRYDPVVGKSFEAFAIPTIIGEIKRFLRDKT WSVHVPRRIKELGPRIKMAVDQLTTETQRSPKVEEIAEFLDVSEEEVLETMEMGKSYQ ALSVDHSIEADSDGSTVTILDIVGSQEDGYERVNQQLMLQSVLHVLSDREKQIIDLTY IQNKSQKETGDILGISQMHVSRLQRKAVKKLREALIEDPSMELM*" gene 522862..523650 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" CDS 523650..524249 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine phosphatase" /protein_id="NP_388355.1" /db_xref="EnsemblGenomes-Gn:BSU04740" /db_xref="EnsemblGenomes-Tr:CAB12281" /db_xref="GOA:P17906" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR036457" /db_xref="PDB:3W40" /db_xref="PDB:3W41" /db_xref="PDB:3W42" /db_xref="PDB:3W43" /db_xref="PDB:3W44" /db_xref="PDB:3W45" /db_xref="SubtiList:BG10736" /db_xref="UniProtKB/Swiss-Prot:P17906" /translation="MIQVEENEHIQTLVYQLNKEGKSICGDSFFMKADDKELICAVAD GLGSGSLANESSAAIKDLVENYASEDVESIIERCNQAMKNKRGATASILKINFEQRQF TYCSVGNVRFILHSPSGESFYPLPISGYLSGKPQKYKTHTATYEKGSKFIIHTDGLNV PDIRSHLKKGQSVEEISNSLKMYTTSRKDDLTYILGQLS*" gene 523650..524249 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" downshifts 524235 /Source="Nicolas_upshifts" /id="D225" /incds=0 /nref=267 /ntot=278 /MaxReadThrough="2.46753" /MaxDrop="7.92167" /score="1.26147577" /energy="-6" /TU="NA" /idTUdmin="U369" /TUdmin="-3" /isTUend="TRUE" promotor_-35 524293..524299 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 524314..524333 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 524326 /Source="Nicolas_upshifts" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 524360..524476 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513945.1" /translation="MWNYEYTAIADVDVGKPGTVIRKQKQWINGRRVLHQIL*" gene 524360..524476 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" CDS 524492..524785 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388356.1" /db_xref="EnsemblGenomes-Gn:BSU04750" /db_xref="EnsemblGenomes-Tr:CAB12282" /db_xref="SubtiList:BG12093" /db_xref="UniProtKB/Swiss-Prot:P96623" /translation="MERKEHCFCKEKQFSYGLSMWRNIGRFLSWSTCPHSNVIMEFFH VLQKQKEDLCITYGIVLEGAEAKKWGEIIGTELSKDMPTAVSRLVHLYGGVIK*" gene 524492..524785 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" promotor_-35 524753..524761 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 524773..524792 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 524782..525222 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388357.1" /db_xref="EnsemblGenomes-Gn:BSU04760" /db_xref="EnsemblGenomes-Tr:CAB12283" /db_xref="InterPro:IPR002740" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR022996" /db_xref="SubtiList:BG12094" /db_xref="UniProtKB/Swiss-Prot:P96624" /translation="MNTNYWIGVVSEQHVLKGAAGGFAQLCHGKKAPLAKMKEGDWLI YYSPRDAYPDGKLLRSFTAIGKVKSGNIYPYQMAPNFIPYRLDIDYYPCHKIGFYDIK SKLEFVQETKHLGFLFRRGHFEISKKDFLTIAQAMGVNISGMAL*" gene 524782..525222 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" upshifts 524788 /Source="Nicolas_upshifts" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" S_feature complement(525021..528076) /Source="Nicolas_S_feature" /locus_tag="new_525021_528076_c" /HighExp="S6, S8, S7, S5, B36, S4, B60, BT, Pyr, C30" /AntisenseName="ydcI" /AntisenseCor="-0.61304426345041496" /AntisenseRegPval="-28.4" /CDS_PredictionProba="0.40759499999999999" /TUshortSig="SigK" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S166" CDS 525206..525649 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12088660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388358.1" /db_xref="EnsemblGenomes-Gn:BSU04770" /db_xref="EnsemblGenomes-Tr:CAB12284" /db_xref="GOA:P96625" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12095" /db_xref="UniProtKB/Swiss-Prot:P96625" /translation="MEWHSKFSGPNTSPGFLLWQATQSWQRKVGKALAEFDLTHVQFV LLTSCKYMIAHGETVTQKKLASFSQTNIMMVSEVVRTLEKKGFIERSKNPQDKREVLL SLTEIGGEKVTAALPIVEKIDQAFFAAAMKKENFLSGLQELLKHE*" gene 525206..525649 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" downshifts 525624 /Source="Nicolas_upshifts" /id="D226" /incds=0 /nref=11 /ntot=147 /MaxReadThrough="2.17786" /MaxDrop="3.86856" /score="21.3746204" /energy="-6.8" /TU="NA" /idTUdmin="U376" /TUdmin=0 /isTUend="TRUE" promotor_-35 525680..525681 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-35" promotor_-10 525697..525716 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-10" upshifts 525697 /Source="Nicolas_upshifts" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" CDS 525743..527902 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755871, 12910271, 15383836, 16282592; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA helicase transcriptional accessory protein" /protein_id="NP_388359.2" /db_xref="EnsemblGenomes-Gn:BSU04780" /db_xref="EnsemblGenomes-Tr:CAB12285" /db_xref="GOA:O31489" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018974" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR023319" /db_xref="InterPro:IPR023323" /db_xref="InterPro:IPR032639" /db_xref="SubtiList:BG12096" /db_xref="UniProtKB/Swiss-Prot:O31489" /translation="METSALLKQQIAKEIGLSQKHVESVIRLLEDGNTVPFIARYRKE QTGSMDEVQIQTISERWQYIQNLNQRKEEVIRLIAEQDKLTDNLKRKIEQSVKLQEVE DLYRPYKQKRKTKATVAKSKGLEPLADYILTLPQDDHLAATADQYISEEKEVFTREEA IEGAKHIIAEQISDEPTFRKWIRQETFKRGTIKSAAGKSADTDEKNVYEMYYEYEEPI AKVVPHRVLAMNRGEKEDILKVAIEPPADHIKAYLEKQIIKNRSTSVREILQETIEDS YKRLIQPAIEREIRKELSEKADEQAIHIFSENLRKLLLQPPMKGKTVLGVDPAFRTGC KLAVSDETGKVLKIDVIYPHAPVNKTKEAHEKVKKILEQYQVEMVAIGNGTASRETEQ FIVNVLRDMPRKIYYVIVNEAGASVYSASELAREEFPDLKVEERSAVSIARRLQDPLA ELVKIDPKSVGVGQYQHDVSQKRLNESLRFVVETVVNQVGVNVNTASAALLQYVAGLS KSVAGNVVKKREEIGKFSNRKELKDIPRLGAKTYEQCIGFLRVQEGTEPLDRTGIHPE SYKETKALLKKLGLSTEHIGTAELKDKINQLALSETAKELGIGEITLKDICEQLTRPE RDPRDKVPKPLLKTDVLQLEDLKEGMELQGTVRNVVDFGAFVDIGVKQDGLVHISKLS NQFVKHPLDVVSVGDIVTVWVDGVDVQKGRVSLSMVK*" gene 525743..527902 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" misc_feature 527890..527909 /Source="Nicolas_upshift_promotors" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 527912..528128 /Source="Nicolas_S_feature" /locus_tag="new_527912_528128" /HighExp="Cold, Etha, LBGstat, dia5, LPhT, T4.0H, dia15, T3.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S167" upshifts 527912 /Source="Nicolas_upshifts" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" CDS complement(527912..528025) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" /function="16.3: Control" /function="16.6: Maintain" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:22463703, 26387458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22463703, 26387458; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor allowing degradation of SpoIVA by ClpXP" /protein_id="YP_009513946.1" /translation="MPNWLKKQMQKAFLEKDNYQIKLLNQCWYFYRKKHCS*" gene complement(527912..528025) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" promotor_-10 complement(528065..528084) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(528082) /Source="Nicolas_upshifts" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" promotor_-35 complement(528099..528107) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-35" CDS 528129..528581 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388360.1" /db_xref="EnsemblGenomes-Gn:BSU04790" /db_xref="EnsemblGenomes-Tr:CAB12286" /db_xref="GOA:P96628" /db_xref="InterPro:IPR006640" /db_xref="InterPro:IPR023524" /db_xref="InterPro:IPR035240" /db_xref="SubtiList:BG12098" /db_xref="UniProtKB/Swiss-Prot:P96628" /translation="MDNKELQKLTEDISETYFKKPFRHQALFNDRLKTTGGRYLLTSH NIELNRKYLIEHGREELIGIIKHELCHYHLHLEGKGYKHRDRDFRMLLQQVNAPRFCT PLKKKAENKKTYMYICTTCGQQYIKKRAMNPDRYRCGKCRGKIKRIFS*" gene 528129..528581 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" promotor_-35 528587..528593 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 528608..528627 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 528616..528703 /Source="Nicolas_S_feature" /locus_tag="new_528616_528703" /HighExp="C30, LBGstat, Cold, UNK1, GM 25, GM 120, GM 15, Heat, T-3.40H, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S168" upshifts 528616 /Source="Nicolas_upshifts" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" downshifts complement(528648) /Source="Nicolas_upshifts" /id="D227" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="2.50342" /MaxDrop="3.97305" /score="8.78044068" /energy="-9.2" /TU="NA" /idTUdmin="U381" /TUdmin=704 /isTUend="FALSE" tRNA 528704..528778 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 528704..528778 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" tRNA 528783..528873 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 528783..528873 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" tRNA 528903..528974 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 528903..528974 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" tRNA 528986..529060 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 528986..529060 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" tRNA 529087..529162 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 529087..529162 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" tRNA 529174..529255 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 529174..529255 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" downshifts 529320 /Source="Nicolas_upshifts" /id="D228" /incds=0 /nref=3 /ntot=136 /MaxReadThrough="6.94232" /MaxDrop="3.5424" /score="34.987622" /energy="-13.7" /TU="U380" /idTUdmin="U378" /TUdmin=0 /isTUend="TRUE" tRNA 529336..529422 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu (GAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 529336..529422 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" downshifts 529409 /Source="Nicolas_upshifts" /id="D229" /incds=0 /nref=82 /ntot=235 /MaxReadThrough="4.38481" /MaxDrop="5.23398" /score="34.987622" /energy="-13.7" /TU="U380" /idTUdmin="U378" /TUdmin=89 /isTUend="FALSE" S_feature 529454..530352 /Source="Nicolas_S_feature" /locus_tag="new_529454_530352" /HighExp="Cold, G180, G135, Paraq, Oxctl, C30, G150, H2O2, Fru, Lbexp" /AntisenseName="ydcL" /AntisenseCor="-0.23338643759911901" /AntisenseRegPval="-4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S169" downshifts complement(529477) /Source="Nicolas_upshifts" /id="D230" /incds=0 /nref=96 /ntot=231 /MaxReadThrough="2.93365" /MaxDrop="6.05127" /score="8.78044068" /energy="-9.2" /TU="U381" /idTUdmin="U381" /TUdmin="-125" /isTUend="FALSE" CDS complement(529505..530611) /gene="ydcL" /locus_tag="BSU_04800" /old_locus_tag="BSU04800" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22505685; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: integrase" /protein_id="NP_388361.1" /db_xref="EnsemblGenomes-Gn:BSU04800" /db_xref="EnsemblGenomes-Tr:CAB12287" /db_xref="GOA:P96629" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR013762" /db_xref="SubtiList:BG12099" /db_xref="UniProtKB/Swiss-Prot:P96629" /translation="MSVKKLENGQYQVDVSFGFDPITGERIRTRPVASTRKEALELEA KLRREFQEERARKSRSVSFPTLISIYLASCEIDSKPNYYQNQKYIINKHISDYFLKSD IQKITHREITDFRKHLMETGLSNKSVNNIMTSLSKIFDTAVHEEILKRNPCDNVKRLP LTRKKMKFWRPEEFKKFISLIPQDQLLFKTFYTVAFLTGLRCGEMLALQWKDIDKILL EIDVHKSCTWLDGQFVVTTPKTKNSIRRVSINKKLLKLLERWKEAQEELFNELGIRHS HDTYIFQYKDTPSRKDIFSRKIKYFCKDSDLTPIRLHDFRHSHVALLIHQGEDYITIK ERLGHGSVKTTIDVYGHLYPNKQKEMADKLDDLL*" gene complement(529505..530611) /gene="ydcL" /locus_tag="BSU_04800" /old_locus_tag="BSU04800" CDS complement(530624..531133) /gene="immA" /locus_tag="BSU_04810" /old_locus_tag="BSU04810" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:18761623, 21036995, 22505685" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18761623, 21036995, 22505685; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: site-specific protease cleaving ImmR" /protein_id="NP_388362.1" /db_xref="EnsemblGenomes-Gn:BSU04810" /db_xref="EnsemblGenomes-Tr:CAB12288" /db_xref="GOA:P96630" /db_xref="InterPro:IPR010359" /db_xref="SubtiList:BG12100" /db_xref="UniProtKB/Swiss-Prot:P96630" /translation="MITIYTSKGIKHKVQSVIKTHGTNNVYEICDIQKIYILKNDLGQ ANGLLQHDKATDQYLIHINENLQHQQFVIAHELGHYFLHKRLNTFKVVNCSKVLKDKL EHQASLFASELILTDKMLNEALPYIQGFSKEQIAAYFNVPSFVTDYKLSQIGSFSNRI YSHEISAFG*" gene complement(530624..531133) /gene="immA" /locus_tag="BSU_04810" /old_locus_tag="BSU04810" downshifts complement(530936) /Source="Nicolas_upshifts" /id="D231" /incds=1 /nref=12 /ntot=39 /MaxReadThrough="6.14325" /MaxDrop="3.22989" /score="17.0287275" /energy="-11.8" /TU="U381" /idTUdmin="U384" /TUdmin=1518 /isTUend="FALSE" CDS complement(531130..531513) /gene="immR" /locus_tag="BSU_04820" /old_locus_tag="BSU04820" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8083175, 17511812, 22505685" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8083175, 17511812, 22505685; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: transcriptional regulator(Xre family)" /protein_id="NP_388363.1" /db_xref="EnsemblGenomes-Gn:BSU04820" /db_xref="EnsemblGenomes-Tr:CAB12289" /db_xref="GOA:P96631" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR027910" /db_xref="SubtiList:BG12101" /db_xref="UniProtKB/Swiss-Prot:P96631" /translation="MSLGKRLKEARQKAGYTQKEAAEKLNIGNNNLSNYERDYRDPDT DTLLKLSNLYNVSTDYLLGKDEVSKKNETDLLNKTINEAIQELKDEDTLLFMNDGEFD EETARLVKKALKNGIKFIDELKKKE*" gene complement(531130..531513) /gene="immR" /locus_tag="BSU_04820" /old_locus_tag="BSU04820" promotor_-10 complement(531542..531561) /Source="Nicolas_upshift_promotors" /id="U381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=3028 /SigmaFactorBS="tagaattatttatttaacttataggtgaaatTAATGAATtct ccaaaaaatgtTGTTATTATTTTTATAAAAAtcaactctttgtgaaatggatgataaa a" /listShort="immR, immA, ydcL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(531554) /Source="Nicolas_upshifts" /id="U381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=3028 /SigmaFactorBS="tagaattatttatttaacttataggtgaaatTAATGAATtct ccaaaaaatgtTGTTATTATTTTTATAAAAAtcaactctttgtgaaatggatgataaa a" /listShort="immR, immA, ydcL" /GFF_Attribute="listLong" promotor_-35 complement(531576..531583) /Source="Nicolas_upshift_promotors" /id="U381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=3028 /SigmaFactorBS="tagaattatttatttaacttataggtgaaatTAATGAATtct ccaaaaaatgtTGTTATTATTTTTATAAAAAtcaactctttgtgaaatggatgataaa a" /listShort="immR, immA, ydcL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 531713..531720 /Source="Nicolas_upshift_promotors" /id="U382" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2860 /SigmaFactorBS="tgttcaaaaaaatacactttaaggtgaattttgTGTTGACTt acacgaaaaggagTTTTATAATAAAGTTAATTCacaaagagttgagttaacgaggagg t" /listShort="sacV, ydzL, ydcO, S171, ydcP, ydcQ, ydcR" /listLong="S172, ydcS, ydcT, yddA, yddB, yddC, yddD, yddE, yddF, yddG, yddH, yddI, yddJ" /label="promotor_-35" promotor_-10 531735..531754 /Source="Nicolas_upshift_promotors" /id="U382" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2860 /SigmaFactorBS="tgttcaaaaaaatacactttaaggtgaattttgTGTTGACTt acacgaaaaggagTTTTATAATAAAGTTAATTCacaaagagttgagttaacgaggagg t" /listShort="sacV, ydzL, ydcO, S171, ydcP, ydcQ, ydcR" /listLong="S172, ydcS, ydcT, yddA, yddB, yddC, yddD, yddE, yddF, yddG, yddH, yddI, yddJ" /label="promotor_-10" upshifts 531740 /Source="Nicolas_upshifts" /id="U382" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2860 /SigmaFactorBS="tgttcaaaaaaatacactttaaggtgaattttgTGTTGACTt acacgaaaaggagTTTTATAATAAAGTTAATTCacaaagagttgagttaacgaggagg t" /listShort="sacV, ydzL, ydcO, S171, ydcP, ydcQ, ydcR" /listLong="S172, ydcS, ydcT, yddA, yddB, yddC, yddD, yddE, yddF, yddG, yddH, yddI, yddJ" CDS 531787..531981 /gene="xis" /locus_tag="BSU_04830" /old_locus_tag="BSU04830" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3269394, 17511812, 22505685, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3269394, 17511812, 22505685, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: excisionase" /protein_id="NP_388364.1" /db_xref="EnsemblGenomes-Gn:BSU04830" /db_xref="EnsemblGenomes-Tr:CAB12290" /db_xref="GOA:O31490" /db_xref="SubtiList:BG12670" /db_xref="UniProtKB/Swiss-Prot:O31490" /translation="MKGEFLTARDIQKILGVKQAKSYDIIRTLNAQMKEEGYMVIQGK VSRAKFEECYCYKGPKSQTG*" gene 531787..531981 /gene="xis" /locus_tag="BSU_04830" /old_locus_tag="BSU04830" CDS 531978..532238 /gene="ydzL" /locus_tag="BSU_04839" /old_locus_tag="BSU04839" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22505685, 26013486; Product type h:extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: conserved protein of unknown function" /protein_id="YP_003097681.1" /db_xref="EnsemblGenomes-Gn:BSU04839" /db_xref="EnsemblGenomes-Tr:CAX52552" /db_xref="UniProtKB/Swiss-Prot:C0H3V5" /translation="MIFINIDITNSFMKEAVPLARQMEGDWIARMKIALNSVIINHYL NLPLTIENVNELLRKGVSYRRICKHYGIGRKDIEKLRQSSVV*" gene 531978..532238 /gene="ydzL" /locus_tag="BSU_04839" /old_locus_tag="BSU04839" CDS 532292..532552 /gene="ydcO" /locus_tag="BSU_04840" /old_locus_tag="BSU04840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22505685, 26013486; Product type h:extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: conserved protein of unknown function" /protein_id="NP_388365.1" /db_xref="EnsemblGenomes-Gn:BSU04840" /db_xref="EnsemblGenomes-Tr:CAB12291" /db_xref="SubtiList:BG12102" /db_xref="UniProtKB/Swiss-Prot:P96632" /translation="MKIRVNATIITDVEALKADKDLNHFKDYATCETFVVDADNHLKA NEEISELLKGWDWWCIWSTRPLSKKDNQVFTLYNDDLYNLCR*" gene 532292..532552 /gene="ydcO" /locus_tag="BSU_04840" /old_locus_tag="BSU04840" S_feature complement(532412..532652) /Source="Nicolas_S_feature" /locus_tag="new_532412_532652_c" /HighExp="T5.0H, T4.0H, T3.0H, Lbstat, T3.30H, T2.0H, Cold, Gly, S2, T2.30H" /AntisenseName="ydcO" /AntisenseCor="0.131178357364787" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S170" promotor_-35 532578..532585 /Source="Nicolas_upshift_promotors" /id="U383" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.99000999000999" /xcortree=2861 /SigmaFactorBS="tgtcgataggagtgtttgttccttgaaaactacaTATAGACA aaaaaagcgccttgACGAATGATCATCAAGAACGccggaaaataaaaactagacactt t" /listShort="S171, ydcP, ydcQ, ydcR, S172, ydcS, ydcT, yddA, yddB, yddC, yddD, yddE, yddF, yddG, yddH, yddI, yddJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(532583..532642) /gene="sncO" /locus_tag="BSU_misc_RNA_65" /product="ICEBs1 mobile element: conserved small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796, 22505685" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796, 22505685; Product type n: RNA" gene complement(532583..532642) /gene="sncO" /locus_tag="BSU_misc_RNA_65" promotor_-10 532600..532619 /Source="Nicolas_upshift_promotors" /id="U383" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.99000999000999" /xcortree=2861 /SigmaFactorBS="tgtcgataggagtgtttgttccttgaaaactacaTATAGACA aaaaaagcgccttgACGAATGATCATCAAGAACGccggaaaataaaaactagacactt t" /listShort="S171, ydcP, ydcQ, ydcR, S172, ydcS, ydcT, yddA, yddB, yddC, yddD, yddE, yddF, yddG, yddH, yddI, yddJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 532604..532921 /Source="Nicolas_S_feature" /locus_tag="new_532604_532921" /HighExp="T0.30H, T0.0H, T1.0H, T1.30H, T-0.40H, T2.0H, HiOs, T2.30H, MG 120, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.99, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S171" upshifts 532604 /Source="Nicolas_upshifts" /id="U383" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.99000999000999" /xcortree=2861 /SigmaFactorBS="tgtcgataggagtgtttgttccttgaaaactacaTATAGACA aaaaaagcgccttgACGAATGATCATCAAGAACGccggaaaataaaaactagacactt t" /listShort="S171, ydcP, ydcQ, ydcR, S172, ydcS, ydcT, yddA, yddB, yddC, yddD, yddE, yddF, yddG, yddH, yddI, yddJ" /GFF_Attribute="listLong" promotor_-10 complement(532637..532656) /Source="Nicolas_upshift_promotors" /id="U384" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78021978021978" /psig="0.987012987012987" /xcortree=3113 /SigmaFactorBS="tttaaagtgattgctgttcatcactcaaatactcaCGCATGA CatttcaacaagaaTACCGTATAATAAAAGTGTCtagtttttattttccggcgttctt g" /listShort="S170" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(532652) /Source="Nicolas_upshifts" /id="U384" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78021978021978" /psig="0.987012987012987" /xcortree=3113 /SigmaFactorBS="tttaaagtgattgctgttcatcactcaaatactcaCGCATGA CatttcaacaagaaTACCGTATAATAAAAGTGTCtagtttttattttccggcgttctt g" /listShort="S170" /GFF_Attribute="listLong" promotor_-35 complement(532670..532677) /Source="Nicolas_upshift_promotors" /id="U384" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78021978021978" /psig="0.987012987012987" /xcortree=3113 /SigmaFactorBS="tttaaagtgattgctgttcatcactcaaatactcaCGCATGA CatttcaacaagaaTACCGTATAATAAAAGTGTCtagtttttattttccggcgttctt g" /listShort="S170" /GFF_Attribute="listLong" /label="promotor_-35" CDS 532758..532886 /locus_tag="BSU_04849" /old_locus_tag="BSU04849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 22505685" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: hypothetical protein" /protein_id="YP_009513947.1" /translation="MMAIISLLGCHEGVKPLATDKRQDGYRTGANQKHKIEINVLL*" gene 532758..532886 /locus_tag="BSU_04849" /old_locus_tag="BSU04849" CDS 532922..533302 /gene="helP" /locus_tag="BSU_04850" /old_locus_tag="BSU04850" /experiment="publication(s) with functional evidences, PMID:22505685, 23326247, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22505685, 23326247, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: helicase processivity factor" /protein_id="NP_388366.1" /db_xref="EnsemblGenomes-Gn:BSU04850" /db_xref="EnsemblGenomes-Tr:CAB12292" /db_xref="InterPro:IPR010365" /db_xref="SubtiList:BG12103" /db_xref="UniProtKB/Swiss-Prot:P96633" /translation="MNLNFIVPDINMTFGDMKFMGLNRERYVYDRENNKRTDVLESRI YNIASAVQGGQIEVTIPEYAGAKEIPPFADIELKNPKISAMATSQRDSTYANVMWKLE ADDIVVKGGSSVKPAAATGGNEKK*" gene 532922..533302 /gene="helP" /locus_tag="BSU_04850" /old_locus_tag="BSU04850" CDS 533338..534780 /gene="conQ" /locus_tag="BSU_04860" /old_locus_tag="BSU04860" /experiment="publication(s) with functional evidences, PMID:17511812, 22505685, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17511812, 22505685, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: coupling conjugation protein VirD4" /protein_id="NP_388367.1" /db_xref="EnsemblGenomes-Gn:BSU04860" /db_xref="EnsemblGenomes-Tr:CAB12293" /db_xref="GOA:P96634" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12104" /db_xref="UniProtKB/Swiss-Prot:P96634" /translation="MSDFLNKRFWKYRGKRIRPYMRNNVKLAGAIIFVPVFLLSMFLF WREQLIHFDLSQVIKNFEWNVPLIIKSVLCSVLIAVGSIVASYFLLFDSYKKILHRQK IAKMIFSNKFYEKENVKVRKIFSNETDSKEKITYFPRMYYQVKNNHIYIRIAMDMSRF QNRFLDLGKDLENGLFCDLVDKQMEEGFVCFKLLYDVKKNRISIDDAVAENGVLPLMK HISWQFDKLPHMLIAGGTGGGKTYFMLTIIKACVGLGADVRILDPKNADLADLEEVLP KKVYSQKNGILMCLRKSVDGMMERMDEMKQMSNYKTGENYAYLGLKPVFIFFDEYVAF MDLLDMKERNEALSYMKQLVMLGRQAGYFLVLGAQRPDAKYLADGIRDQFSFRVSLGL MSDTGYGMMFGDVEKAYVNKKETGRGYANVGTGSVLEFYSPIVPKGYDFMSSIKNALV GVEGAQATAVASGSVSDQTASGEGVSEANG*" gene 533338..534780 /gene="conQ" /locus_tag="BSU_04860" /old_locus_tag="BSU04860" CDS 534773..535831 /gene="nicK" /locus_tag="BSU_04870" /old_locus_tag="BSU04870" /experiment="publication(s) with functional evidences, PMID:17511812, 17693500, 22505685, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17511812, 17693500, 22505685, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: DNA relaxase" /protein_id="NP_388368.1" /db_xref="EnsemblGenomes-Gn:BSU04870" /db_xref="EnsemblGenomes-Tr:CAB12294" /db_xref="GOA:P96635" /db_xref="InterPro:IPR003491" /db_xref="SubtiList:BG12105" /db_xref="UniProtKB/Swiss-Prot:P96635" /translation="MDELKQPPHANRGVVIVKEKNEAVESPLVSMVDYIRVSFKTHDV DRIIEEVLHLSKDFMTEKQSGFYGYVGTYELDYIKVFYSAPDDNRGVLIEMSGQGCRQ FESFLECRKKTWYDFFQDCMQQGGSFTRFDLAIDDKKTYFSIPELLKKAQKGECISRF RKSDFNGSFDLSDGITGGTTIYFGSKKSEAYLCFYEKNYEQAEKYNIPLEELGDWNRY ELRLKNERAQVAIDALLKTKDLTLIAMQIINNYVRFVDADENITREHWKTSLFWSDFI GDVGRLPLYVKPQKDFYQKSRNWLRNSCAPTMKMVLEADEHLGKTDLSDMIAEAELAD KHKKMLDVYMADVADMVV*" gene 534773..535831 /gene="nicK" /locus_tag="BSU_04870" /old_locus_tag="BSU04870" downshifts 534776 /Source="Nicolas_upshifts" /id="D232" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="5.48512" /MaxDrop="3.25403" /score="-9.5933493" /energy="-23.1" /TU="U382,U383" /idTUdmin="U382" /TUdmin="-176" /isTUend="FALSE" S_feature 535832..536095 /Source="Nicolas_S_feature" /locus_tag="new_535832_536095" /HighExp="T0.30H, T1.0H, T1.30H, T0.0H, T2.0H, T2.30H, T-0.40H, T3.0H, T3.30H, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="SigA" /TUlongPSig=1 /label="S172" CDS 536096..536365 /gene="ydcS" /locus_tag="BSU_04880" /old_locus_tag="BSU04880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22505685; Product type h :extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: conserved protein of unknown function" /protein_id="NP_388369.1" /db_xref="EnsemblGenomes-Gn:BSU04880" /db_xref="EnsemblGenomes-Tr:CAB12295" /db_xref="SubtiList:BG12106" /db_xref="UniProtKB/Swiss-Prot:P96636" /translation="MHNVNLLNQAGLENALESVGCLDIVEDLIEKMQEYVLYHTETAE RFAIDIFTVVNNYTKKVHAIFNVLENEDGETNVKNVEFEVMHFTE*" gene 536096..536365 /gene="ydcS" /locus_tag="BSU_04880" /old_locus_tag="BSU04880" promotor_-10 complement(536156..536175) /Source="Nicolas_upshift_promotors" /id="U385" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.956043956043956" /psig="0.998001998001998" /xcortree=2065 /SigmaFactorBS="aatctttcggcagtttcggtatgatacaaaacataTTCCTGC AtcttttctattaaaTCTTCTACAATATCTAAACAgccaactgattccaaagcatttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(536172) /Source="Nicolas_upshifts" /id="U385" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.956043956043956" /psig="0.998001998001998" /xcortree=2065 /SigmaFactorBS="aatctttcggcagtttcggtatgatacaaaacataTTCCTGC AtcttttctattaaaTCTTCTACAATATCTAAACAgccaactgattccaaagcatttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(536190..536197) /Source="Nicolas_upshift_promotors" /id="U385" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.956043956043956" /psig="0.998001998001998" /xcortree=2065 /SigmaFactorBS="aatctttcggcagtttcggtatgatacaaaacataTTCCTGC AtcttttctattaaaTCTTCTACAATATCTAAACAgccaactgattccaaagcatttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 536404..536670 /gene="ydcT" /locus_tag="BSU_04890" /old_locus_tag="BSU04890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22505685; Product type h :extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: conserved protein of unknown function" /protein_id="NP_388370.1" /db_xref="EnsemblGenomes-Gn:BSU04890" /db_xref="EnsemblGenomes-Tr:CAB12296" /db_xref="SubtiList:BG12107" /db_xref="UniProtKB/Swiss-Prot:P96637" /translation="MFNINLLNQARLESDLDSLGCLDIAEELIEKMMEDVFYSDVAQR IIVQTLAVINNANAKLQATFNILEDEDMETDERSVEFEGISYYE*" gene 536404..536670 /gene="ydcT" /locus_tag="BSU_04890" /old_locus_tag="BSU04890" CDS 536687..536995 /gene="yddA" /locus_tag="BSU_04900" /old_locus_tag="BSU04900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22505685; Product type h :extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: conserved protein of unknown function" /protein_id="NP_388371.1" /db_xref="EnsemblGenomes-Gn:BSU04900" /db_xref="EnsemblGenomes-Tr:CAB12297" /db_xref="SubtiList:BG12108" /db_xref="UniProtKB/Swiss-Prot:P96638" /translation="MSAVDKRFKSLGFNVGIPSLVFVRSLSRDCMLVVEGERVKGFAE YRYTFYKTRYLPDGRMTSLKVYMENQSIKRVLHRVASFLSFLERTKQIEQKECEKVAQ *" gene 536687..536995 /gene="yddA" /locus_tag="BSU_04900" /old_locus_tag="BSU04900" CDS 536985..538049 /gene="conB" /locus_tag="BSU_04910" /old_locus_tag="BSU04910" /experiment="publication(s) with functional evidences, PMID:22505685, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22505685, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: subunit of the conjugation machinery VirB8" /protein_id="NP_388372.1" /db_xref="EnsemblGenomes-Gn:BSU04910" /db_xref="EnsemblGenomes-Tr:CAB12298" /db_xref="GOA:O31491" /db_xref="InterPro:IPR024735" /db_xref="InterPro:IPR035628" /db_xref="SubtiList:BG12109" /db_xref="UniProtKB/Swiss-Prot:O31491" /translation="MLNKEIGSDKKEESFFRSAFQKLKRIERPEKDKQKVPRDRSKLI AVTLWSCVGSLLFICLLAVLLSINTRSQLNDMKDETNKPTNDDKQKISVTAAENFLSG FINEYMNVKNDQESIEKRMQSLESYMVKQEDNHFEDEERFNVDGLKGDRELKGYSLYN VKEGDKNSLFQYKVTYENLYPVEKEVEKEVKDGKKKKKVKEKVKTNEKYEKQMLLNIP VTNKGDSFAVSAVPYFTQIYDLKGDIAFKGKEETRDEYAGEKKESIESFLQNFFEKYA SEKKEEMVYMMKKPEALEGNLLFGEVQSVKIFETKKGFEVFCAVRFKEKENDIPVNEK FSLEITENSGQFYVNKLKHQ*" gene 536985..538049 /gene="conB" /locus_tag="BSU_04910" /old_locus_tag="BSU04910" misc_feature 537523..537530 /Source="Nicolas_upshift_promotors" /id="U386" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.454545454545455" /xcortree=1489 /SigmaFactorBS="tgaaagaaggtgataaaaacagcctttttcaatataaggtca catatgaaaatctatACCCTGTAgaaaaggaagttgaaaaagaagttaaagacggaaa g" /listShort="yddC, yddD, yddE, yddF, yddG, yddH, yddI" /listLong="yddJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 537526 /Source="Nicolas_upshifts" /id="U386" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.454545454545455" /xcortree=1489 /SigmaFactorBS="tgaaagaaggtgataaaaacagcctttttcaatataaggtca catatgaaaatctatACCCTGTAgaaaaggaagttgaaaaagaagttaaagacggaaa g" /listShort="yddC, yddD, yddE, yddF, yddG, yddH, yddI" /listLong="yddJ" downshifts 537614 /Source="Nicolas_upshifts" /id="D233" /incds=1 /nref=1 /ntot=15 /MaxReadThrough="6.32422" /MaxDrop="3.45679" /score="-2.67923628" /energy="-7.8" /TU="U383,U386" /idTUdmin="U382" /TUdmin=2662 /isTUend="FALSE" CDS 538061..538309 /gene="conC" /locus_tag="BSU_04920" /old_locus_tag="BSU04920" /function="18: Unknown function" /experiment="publication(s) with functional evidences, PMID:22505685, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22505685, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: subunit of the conjugation machinery" /protein_id="NP_388373.1" /db_xref="EnsemblGenomes-Gn:BSU04920" /db_xref="EnsemblGenomes-Tr:CAB12299" /db_xref="GOA:P96640" /db_xref="SubtiList:BG12110" /db_xref="UniProtKB/Swiss-Prot:P96640" /translation="MDFMNFFILGADLPTLGGVKGWASDVVIQFITIVVMFIAAKNLM KLKMGGIIFVCCIGSAVTWVIKHWSEFSGWINALMEKL*" gene 538061..538309 /gene="conC" /locus_tag="BSU_04920" /old_locus_tag="BSU04920" CDS 538322..538846 /gene="conD" /locus_tag="BSU_04930" /old_locus_tag="BSU04930" /experiment="publication(s) with functional evidences, PMID:22505685, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22505685, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: subunit of the conjugation machinery" /protein_id="NP_388374.1" /db_xref="EnsemblGenomes-Gn:BSU04930" /db_xref="EnsemblGenomes-Tr:CAB12300" /db_xref="GOA:P96641" /db_xref="InterPro:IPR025608" /db_xref="SubtiList:BG12111" /db_xref="UniProtKB/Swiss-Prot:P96641" /translation="MGRLVFNYRKAMREPKKIQQLTENYSLPFAVELIPAINYFIFVG LCFGFWYGVRMIFPHAFDNSYVIVIFGIPFFLTMLVTKIKPEGKNIYIYFFDFAKYYF FIKLPQKKYCNDRKIDLSNEKQIEFRKLVKVVDYSNETKNAYEGNTQEFAVNKNGRRV GVLPNKKQFDSYAK*" gene 538322..538846 /gene="conD" /locus_tag="BSU_04930" /old_locus_tag="BSU04930" CDS 538734..541229 /gene="conE" /locus_tag="BSU_04940" /old_locus_tag="BSU04940" /experiment="publication(s) with functional evidences, PMID:19734305, 19943900, 22505685, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19734305, 19943900, 22505685, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: VirB4-like ATPase" /protein_id="NP_388375.3" /db_xref="EnsemblGenomes-Gn:BSU04940" /db_xref="EnsemblGenomes-Tr:CAB12301" /db_xref="GOA:P96642" /db_xref="InterPro:IPR016628" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12112" /db_xref="UniProtKB/Swiss-Prot:P96642" /translation="MRLKTPMKAIHKNLLLTRTGDVWAYYRIKSNSIPMQNKEKVESY KKKWQHLFEEITSYEDFHLMMYPSEYELEKRFKDLETDIAADAMDVARYYNEETVRLL EQRLGRLTKYDFILGVKLKSSLVNISVELKDNILSFFNTATDTVVKMLGWEQNVSTSF FEKYEEVEETLANIMASVRGERLSETEMTYINRYHFVRGLKHQTNEESEIKDVRSITN TIIDPTDPSVLHLHSDQDEGYSAFVVIDEFLHNMSESDLFYEAQSLPFPVEVQMKIQT ESKSITKPALNLKRQQLKEEQKEQQSTGDRSDVSTVTSATMIRHLQDEIKKEDVHVMN WLSVIVVHGKTKKECVGKATIVKRHLKGAGITCRLPVADQLNLFYKMLPGEKLDITDK NWIQKTTQDGVAESLFAVNSDIGSKIGFFLGWVDRFQEHTDLESAIMSSRDFVLFHPF LANQQLKGSKTRSPHCLITGDTGNGKSYLAKLIFNYISMLNIKSLYIDPKKEMRKWIQ RVLNDEYIRENFPLYIAHLEKYNYITLDHENTHNWGALDPISFLPPMKAKELVQVIFE QVYDFKGKDDINTAFLRATSEVIDAKQKGEQVGSLDIIRKMQSHPEEAVQKAGDYLNE VVSDSILKLCIHDGSNPALSLEKRITILEVENMDLPDHAERLENYTISQLKSSAVMFA LGKFCELFGMNQDEQTVEFIDEAWIFTTSQQGKKVERQMRRIGRSYNNAEYFISQSTK DALKEEDSGNFGVAFAFDEPNEREEVLKWMNMEVTKDNKKMMESMFQGQCLFKDYYGR TSKISIECLFEEWQGALKTVEKKAVAYAEEKYL*" gene 538734..541229 /gene="conE" /locus_tag="BSU_04940" /old_locus_tag="BSU04940" CDS 541248..541574 /gene="yddF" /locus_tag="BSU_04950" /old_locus_tag="BSU04950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19943900, 22505685, 26013486; Producttype h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: conserved protein of unknown function" /protein_id="NP_388376.1" /db_xref="EnsemblGenomes-Gn:BSU04950" /db_xref="EnsemblGenomes-Tr:CAB12302" /db_xref="InterPro:IPR015055" /db_xref="SubtiList:BG12113" /db_xref="UniProtKB/Swiss-Prot:P96643" /translation="MEIAFLNSLVVTSPGFYKAEKITLDEVKQWLKHYDGRYKSFIGH KSTAQFLQKLLGIRIEQNRKTFRHMKYQKAICFSLYERYPENVLLTQRDLEKARYQFY LLTRLD*" gene 541248..541574 /gene="yddF" /locus_tag="BSU_04950" /old_locus_tag="BSU04950" CDS 541578..544025 /gene="conG" /locus_tag="BSU_04960" /old_locus_tag="BSU04960" /experiment="publication(s) with functional evidences, PMID:19943900, 22505685, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19943900, 22505685, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: VirB6 subunit of the conjugation machinery" /protein_id="NP_388377.1" /db_xref="EnsemblGenomes-Gn:BSU04960" /db_xref="EnsemblGenomes-Tr:CAB12303" /db_xref="GOA:P96644" /db_xref="InterPro:IPR000515" /db_xref="SubtiList:BG12114" /db_xref="UniProtKB/Swiss-Prot:P96644" /translation="MVVMKKKRILIVSAIVLLFLTVASAVTVFSADGDTTTQPKVEKA GGVELKVKRFPISRYQANNEASDDLIKGAFVGLTNVTFSFAGNIVRVVDTGMDILYNL QPIDEFANSITNVSKTVYKTLKKNFGEALFIFTCAYVVYLFCVRGSVKEAMRRSILFI CVMVIGGLWMSNAGYYMKVLNALSVEAQGKLLTAGNGLVGIVQDEGNFADSSAIEKGK EMEGTVAVMRNLYFDIALMKPFLIVNFDETSEKKINEEDTDKGGLNRIDKLLSYKLSE DGEKDKKDYIKETEIDDYKNESMTSGNVFNQLGESFIAVVASIVIGIPFLALAFFNFL LQVVALVIVFFVPFAFILAYVPQLAYSGFVTLGRLGSVYLLKAMLGVIVLFVYVTCFI VDKLIPPNGFGMYLLNVAVLASILWIGFHKRDAIIKFVTAGKVVSVDNNMMENMRQNI VQPAWEQAKKIGGVWGNGGGVFTDFTKHFGGRKDGSNADGVTGAPSGGGNSPSGTAMG YDNTHAISRTPQKETANGIANHNSRSLKRNPQTLSKEQEKQKQKEAFANAKENKQQSH LARLRKDGINSPMLKDALNEGNEDLSKRAPILQDKKDESARTDQKEYVEQLLKQPNNQ QQTDDASLQHEEESTSNRAPVLQENEKDTERTDQKAYIYDEQNQNLETDQQQDFEVQK DDSVSNSEPVAQEKTAEIKRSDQKVMMNQPEPQLGFESPQSTKVENQPIANNERKIRP SEPAKVHSDGIRVDEKQAVAPAENKTVSREKQPSSQTIKRTEQSVNSFDQVSLNEIAR RSSSKVEDRLRRDERTR*" gene 541578..544025 /gene="conG" /locus_tag="BSU_04960" /old_locus_tag="BSU04960" CDS 544022..545011 /gene="cwlT" /locus_tag="BSU_04970" /old_locus_tag="BSU04970" /experiment="publication(s) with functional evidences, PMID:18305117, 22505685, 24532767, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18305117, 22505685, 24532767, 26013486; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: two-domain autolysin withN-acetylmuramidase and DL-endopeptidase activity VirB1" /protein_id="NP_388378.1" /db_xref="EnsemblGenomes-Gn:BSU04970" /db_xref="EnsemblGenomes-Tr:CAB12304" /db_xref="GOA:P96645" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG12115" /db_xref="UniProtKB/Swiss-Prot:P96645" /translation="MISKKVVLPLVFSAPFIFFFVLCIVVVMTISRENQVGDDFIGGG DGEYETVGIAPEVERFRAVFEKYARQEGVFDQVNIIMALTMQESGGRSLDIMQSSESI GLPPNSITDPERSIEVGIKHFKKVFKQAGGDVRLTLQAYNFGSGFIDYVKKNGGKYTK KLALDFSRLQAFKMGWKSYGDPSYVDHVMRYVKGSDKNVKPVKGSMDFYETVMKEALK YEGQPYAWGGSNPETGFDCSGLVQWSFAKAGITLPRTAQEQHGATKKISEKEATAGDL VFFGGTYEGKAITHVGIYVGNGRMFNSNDSGIQYSDLKSGYWRDHLVSFGRIK*" gene 544022..545011 /gene="cwlT" /locus_tag="BSU_04970" /old_locus_tag="BSU04970" CDS 545026..545532 /gene="yddI" /locus_tag="BSU_04980" /old_locus_tag="BSU04980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22505685; Product type h :extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: conserved protein of unknown function" /protein_id="NP_388379.1" /db_xref="EnsemblGenomes-Gn:BSU04980" /db_xref="EnsemblGenomes-Tr:CAB12305" /db_xref="GOA:P96646" /db_xref="SubtiList:BG12116" /db_xref="UniProtKB/Swiss-Prot:P96646" /translation="MKTHIAWASACLLLVMLTGFFTIGQQTYKIEKLKDKNEVLSEKI KELNHIESTSSASENKAFFEAFFNYSDIDIRYETVKKHTTGKGFDYAFPSRSDQKHTV SVQSELLSLESYSKPLDESHELFLNIVEVATTANSVTTNQVLIVQTTMKKEKDGWLVD NVQVKGNG*" gene 545026..545532 /gene="yddI" /locus_tag="BSU_04980" /old_locus_tag="BSU04980" promotor_-35 545535..545541 /Source="Nicolas_upshift_promotors" /id="U387" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.464535464535465" /psig="0.997002997002997" /xcortree=555 /SigmaFactorBS="ataatgtgcaggttaagggaaatggataaaaGGTGGAAaaga tcaatttgtTTGTTTATACTAAATATTGAaaaaggaggtaatgtttattttgaaaaac c" /listShort="yddJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 545555..545574 /Source="Nicolas_upshift_promotors" /id="U387" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.464535464535465" /psig="0.997002997002997" /xcortree=555 /SigmaFactorBS="ataatgtgcaggttaagggaaatggataaaaGGTGGAAaaga tcaatttgtTTGTTTATACTAAATATTGAaaaaggaggtaatgtttattttgaaaaac c" /listShort="yddJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 545564 /Source="Nicolas_upshifts" /id="U387" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.464535464535465" /psig="0.997002997002997" /xcortree=555 /SigmaFactorBS="ataatgtgcaggttaagggaaatggataaaaGGTGGAAaaga tcaatttgtTTGTTTATACTAAATATTGAaaaaggaggtaatgtttattttgaaaaac c" /listShort="yddJ" /GFF_Attribute="listLong" CDS 545595..545975 /gene="yddJ" /locus_tag="BSU_04990" /old_locus_tag="BSU04990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: putative lipoprotein of unknown function" /protein_id="NP_388380.1" /db_xref="EnsemblGenomes-Gn:BSU04990" /db_xref="EnsemblGenomes-Tr:CAB12306" /db_xref="InterPro:IPR028075" /db_xref="SubtiList:BG12117" /db_xref="UniProtKB/Swiss-Prot:P96647" /translation="MKNLFIFLSLMMMFVLTACGGSKYDDAIDDVISQYKEHKGNDTE INIKRENAIVRVYEGGKYIQFAFYMPDNSSRELTTFKYYEKFGDKYEKMTDMPGNGEN DRLGLSKKTPDYEEVKGEETELEE*" gene 545595..545975 /gene="yddJ" /locus_tag="BSU_04990" /old_locus_tag="BSU04990" downshifts 545952 /Source="Nicolas_upshifts" /id="D234" /incds=0 /nref=167 /ntot=245 /MaxReadThrough="2.07932" /MaxDrop="5.51482" /score="8.08816145" /energy="-14.7" /TU="NA" /idTUdmin="U383" /TUdmin=0 /isTUend="TRUE" downshifts complement(546028) /Source="Nicolas_upshifts" /id="D235" /incds=0 /nref=51 /ntot=228 /MaxReadThrough="3.21157" /MaxDrop="4.80215" /score="-2.66780619" /energy="-18.7" /TU="U388" /idTUdmin="U388" /TUdmin="-110" /isTUend="FALSE" S_feature complement(546051..546165) /Source="Nicolas_S_feature" /locus_tag="new_546051_546165_c" /HighExp="LPhT, Lbtran, Mt0, HiTm, Lbexp, M40t45, M0t45, HPh, dia0, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S173" downshifts complement(546094) /Source="Nicolas_upshifts" /id="D236" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="5.69722" /MaxDrop="4.64006" /score="-2.66780619" /energy="-18.7" /TU="U388" /idTUdmin="U388" /TUdmin="-176" /isTUend="FALSE" CDS complement(546166..546966) /gene="yddK" /locus_tag="BSU_05000" /old_locus_tag="BSU05000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22505685; Product type h :extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: conserved protein of unknown function" /protein_id="NP_388381.1" /db_xref="EnsemblGenomes-Gn:BSU05000" /db_xref="EnsemblGenomes-Tr:CAB12307" /db_xref="GOA:P96648" /db_xref="InterPro:IPR000157" /db_xref="InterPro:IPR035897" /db_xref="SubtiList:BG12118" /db_xref="UniProtKB/Swiss-Prot:P96648" /translation="MDTLKKLKFEANGIIGVLLDYSREPVLTNIIDQFRTSLESNDIE LIRYSLEQLKTWYARNRNEIYKNEFVFNEFEHHETENKIKKFLDELPVVDETEKSSIT HFSSDQNRELEKKIFISHSSKDKIVCNAFVELLEDIGVSSEDIIYTSSPYHGIPGDED IFEYLKKHLFKGAYVFYMLSDNYYDSVYCLNEMGATWVNSNNCSTFILPGFKGEIKGV IDKNKKAFSLEEPIDLFNLKEKILRMYDLTLEDKKWERIKAKFNTKLK*" gene complement(546166..546966) /gene="yddK" /locus_tag="BSU_05000" /old_locus_tag="BSU05000" promotor_-10 complement(547011..547030) /Source="Nicolas_upshift_promotors" /id="U388" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2317 /SigmaFactorBS="tttatgaattacccaaacaatccagactgctttaaaataaGT AGttagaataggagtctATGTTATATAATTAGATATGaaatgtttacaaacaatggat t" /listShort="yddK, S173" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(547029) /Source="Nicolas_upshifts" /id="U388" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2317 /SigmaFactorBS="tttatgaattacccaaacaatccagactgctttaaaataaGT AGttagaataggagtctATGTTATATAATTAGATATGaaatgtttacaaacaatggat t" /listShort="yddK, S173" /GFF_Attribute="listLong" promotor_-35 complement(547046..547049) /Source="Nicolas_upshift_promotors" /id="U388" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2317 /SigmaFactorBS="tttatgaattacccaaacaatccagactgctttaaaataaGT AGttagaataggagtctATGTTATATAATTAGATATGaaatgtttacaaacaatggat t" /listShort="yddK, S173" /GFF_Attribute="listLong" /label="promotor_-35" CDS 547306..548481 /gene="rapI" /locus_tag="BSU_05010" /old_locus_tag="BSU05010" /EC_number="3.1.-.-" /experiment="publication(s) with functional evidences, PMID:16105942, 22505685, 23526881" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16105942, 22505685, 23526881; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: response regulator aspartate phosphatase" /protein_id="NP_388382.1" /db_xref="EnsemblGenomes-Gn:BSU05010" /db_xref="EnsemblGenomes-Tr:CAB12308" /db_xref="GOA:P96649" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:4I1A" /db_xref="SubtiList:BG12119" /db_xref="UniProtKB/Swiss-Prot:P96649" /translation="MRGVFLDKDKIPYDLVTKKLNEWYTSIKNDQVEQAEIIKTEVEK ELLNMEENQDALLYYQLLEFRHEIMLSYMKSKEIEDLNNAYETIKEIEKQGQLTGMLE YYFYFFKGMYEFRRKELISAISAYRIAESKLSEVEDEIEKAEFFFKVSYVYYYMKQTY FSMNYANRALKIFREYEEYAVQTVRCQFIVAGNLIDSLEYERALEQFLKSLEISKESN IEHLIAMSHMNIGICYDELKEYKKASQHLILALEIFEKSKHSFLTKTLFTLTYVEAKQ QNYNVALIYFRKGRFIADKSDDKEYSAKFKILEGLFFSDGETQLIKNAFSYLASRKMF ADVENFSIEVADYFHEQGNLMLSNEYYRMSIEARRKIKKGEIIDENQPDSIGSSDFK* " gene 547306..548481 /gene="rapI" /locus_tag="BSU_05010" /old_locus_tag="BSU05010" promotor_-35 548161..548168 /Source="Nicolas_upshift_promotors" /id="U389" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=2790 /SigmaFactorBS="aacaaaattataatgttgctttgatatacTTTAGGAAagggc gatttattGCCGATAAAAGTGATGATAaggaatactcagcgaaattcaaaatattaga g" /listShort="phrI, yddM, S174" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 548182..548200 /Source="Nicolas_upshift_promotors" /id="U389" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=2790 /SigmaFactorBS="aacaaaattataatgttgctttgatatacTTTAGGAAagggc gatttattGCCGATAAAAGTGATGATAaggaatactcagcgaaattcaaaatattaga g" /listShort="phrI, yddM, S174" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 548192 /Source="Nicolas_upshifts" /id="U389" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=2790 /SigmaFactorBS="aacaaaattataatgttgctttgatatacTTTAGGAAagggc gatttattGCCGATAAAAGTGATGATAaggaatactcagcgaaattcaaaatattaga g" /listShort="phrI, yddM, S174" /GFF_Attribute="listLong" promotor_-35 548389..548395 /Source="Nicolas_upshift_promotors" /id="U390" /multdbtbs="SigH" /comp="M8" /sig="SigGF" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=882 /SigmaFactorBS="agtcgctgattattttcatgaacaaggaaatttaatgctctc taatgaatattatCGTATGAgtattgaagcaagaCGAAAAATTAAAaaaggggagatt a" /listShort="phrI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 548394 /Source="Nicolas_upshifts" /id="U390" /multdbtbs="SigH" /comp="M8" /sig="SigGF" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=882 /SigmaFactorBS="agtcgctgattattttcatgaacaaggaaatttaatgctctc taatgaatattatCGTATGAgtattgaagcaagaCGAAAAATTAAAaaaggggagatt a" /listShort="phrI" /GFF_Attribute="listLong" promotor_-10 548410..548421 /Source="Nicolas_upshift_promotors" /id="U390" /multdbtbs="SigH" /comp="M8" /sig="SigGF" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=882 /SigmaFactorBS="agtcgctgattattttcatgaacaaggaaatttaatgctctc taatgaatattatCGTATGAgtattgaagcaagaCGAAAAATTAAAaaaggggagatt a" /listShort="phrI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 548438..548557 /gene="phrI" /locus_tag="BSU_05020" /old_locus_tag="BSU05020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16816200, 21908671, 22505685" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16816200, 21908671, 22505685; Product type r: regulator" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: secreted regulator of theactivity of phosphatase RapI" /protein_id="NP_388383.1" /db_xref="EnsemblGenomes-Gn:BSU05020" /db_xref="EnsemblGenomes-Tr:CAB12309" /db_xref="SubtiList:BG12645" /db_xref="UniProtKB/Swiss-Prot:O31492" /translation="MKISRILLAAVILSSVFSITYLQSDHNTEIKVAADRVGA*" gene 548438..548557 /gene="phrI" /locus_tag="BSU_05020" /old_locus_tag="BSU05020" downshifts 548555 /Source="Nicolas_upshifts" /id="D237" /incds=0 /nref=46 /ntot=227 /MaxReadThrough="4.14733" /MaxDrop="5.8523" /score="15.7846721" /energy="-10.4" /TU="U389" /idTUdmin="U390" /TUdmin="-15" /isTUend="TRUE" CDS 548710..549651 /gene="yddM" /locus_tag="BSU_05030" /old_locus_tag="BSU05030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22505685; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: putative helicase" /protein_id="NP_388384.1" /db_xref="EnsemblGenomes-Gn:BSU05030" /db_xref="EnsemblGenomes-Tr:CAB12310" /db_xref="GOA:P96650" /db_xref="SubtiList:BG12120" /db_xref="UniProtKB/Swiss-Prot:P96650" /translation="MGENMFKKEKVTEYIWTILIPTIITFIISWVGSYYNGTSTVSIG QPTKVSGQYITPINISPYHDIKELRITFPQKLDVKQISSNEPINVKSDKNNIGVESNS TFEIAKIVENNSVQLLITTQKKLNDKEIRIDKNGNNISVNYESQIVNPAKKQLINLII TSSIYFIMLNILALIMNKRWDKYYAKMKNEIKEFEDNAKDLDKKSKKKSEELSELRKT LNQAFEETDRIKYHEKKKQILLLAKLNDYKKELTFWRNTIRKVLYELPDGDKKADKLI GTVTSSLKTYGTVEKNEHDYESLKVAAALLNDSDKRS*" gene 548710..549651 /gene="yddM" /locus_tag="BSU_05030" /old_locus_tag="BSU05030" S_feature 549652..549910 /Source="Nicolas_S_feature" /locus_tag="new_549652_549910" /HighExp="HPh, S1, Gly, LoTm, LPh, MG 120, GM-0.1, aero, S2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.80510899999999996" /TUshortSig="SigD" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S174" S_feature complement(549923..550239) /Source="Nicolas_S_feature" /locus_tag="new_549923_550239_c" /HighExp="Diami, dia15, dia5, HPh, Etha, H2O2, Cold, LPh, C90, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S175" downshifts 549952 /Source="Nicolas_upshifts" /id="D238" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="0.144629999999999" /MaxDrop="3.58923" /score="4.45688042" /energy="-12.2" /TU="NA" /idTUdmin="U389" /TUdmin=84 /isTUend="FALSE" downshifts complement(549984) /Source="Nicolas_upshifts" /id="D239" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.31925" /MaxDrop="3.67068" /score="-2.66780619" /energy="-18.7" /TU="NA" /idTUdmin="U391" /TUdmin=0 /isTUend="TRUE" CDS complement(550240..551259) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" /EC_number="1.14.14.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_388385.1" /db_xref="EnsemblGenomes-Gn:BSU05040" /db_xref="EnsemblGenomes-Tr:CAB12311" /db_xref="GOA:P96651" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12121" /db_xref="UniProtKB/Swiss-Prot:P96651" /translation="MKKFDISVLSVAPLRQGETMKQGIDSAVSLAKAVDNMGYKRIWF AEHHNHDAYASAATVSIVQHILANTKDIRVGSGGIMLPNHSPLIVAEQFGTLETLYPN RVDLALGRAPGTDQKTADVIRRSNHNGVFFFEREVNDILRFVGDKSVQGEVRAYPGIG THVPVFVLGSSTDSAEIAAKLGLPYAFGAQFSPHSMEEALSIYRENFQPSSYLQEPYV IACINVIAAESIDEASFISASHLQVYIDIYTNNLSKLIPPTENFLESLSQFELEILHS RLGYTIMGDRETIRRELIDFQQMYHADELIVLSNIYELSKEIQSYEILKQVVDELFKK RMEQL*" gene complement(550240..551259) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" promotor_-10 complement(550935..550954) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(550948) /Source="Nicolas_upshifts" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" promotor_-35 complement(550969..550976) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 551048..551052 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 551069..551088 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 551073 /Source="Nicolas_upshifts" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" S_feature 551074..551518 /Source="Nicolas_S_feature" /locus_tag="new_551074_551518" /HighExp="dia15, dia5, H2O2, G180, G135, Paraq, HPh, LBGexp, Lbexp, G150" /AntisenseName="yddN" /AntisenseCor="0.70327972625798696" /AntisenseRegPval="-40.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S176" CDS 551519..551929 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388386.1" /db_xref="EnsemblGenomes-Gn:BSU05050" /db_xref="EnsemblGenomes-Tr:CAB12312" /db_xref="GOA:P96652" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12122" /db_xref="UniProtKB/Swiss-Prot:P96652" /translation="MIDEIDKKILDELSKNSRLTMKKLGEKVHLTAPATASRVVKLID NGIIKGCSIEVNQVKLGFSIHAFLNIYIEKIHHQPYLAFIETQDNYVINNYKVSGDGC YLLECKFPSNEVLDQFLNDLNKHANYKVSIVIGK*" gene 551519..551929 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" S_feature 551930..551999 /Source="Nicolas_S_feature" /locus_tag="new_551930_551999" /HighExp="dia15, dia5, H2O2, HPh, G180, G135, LBGtran, Paraq, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S177" downshifts 551956 /Source="Nicolas_upshifts" /id="D240" /incds=0 /nref=45 /ntot=194 /MaxReadThrough="2.99689" /MaxDrop="3.6808" /score="-1.98969146" /energy="-15.7" /TU="U392" /idTUdmin="U392" /TUdmin="-350" /isTUend="FALSE" CDS complement(552052..552501) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388387.1" /db_xref="EnsemblGenomes-Gn:BSU05060" /db_xref="EnsemblGenomes-Tr:CAB12313" /db_xref="GOA:P96653" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12123" /db_xref="UniProtKB/Swiss-Prot:P96653" /translation="MQIDSIDFQILQLLNKNARIQWKEIGEKIHMTGQAVGNRIKKME DNGIIKAYSIVVDELKMGFSFTAFVFFFMNAYMHDDLLKFIATRNEISEAHRVSGDAC YLLKVTVHSQEVLNHLLNDLLKYGNYQLYLSIKEVKKHYNTSLMSDE*" gene complement(552052..552501) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" CDS 552616..553158 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388388.1" /db_xref="EnsemblGenomes-Gn:BSU05070" /db_xref="EnsemblGenomes-Tr:CAB12314" /db_xref="GOA:P96654" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12124" /db_xref="UniProtKB/Swiss-Prot:P96654" /translation="MTTALLVIDIQNDYFPNGKMALTNPEKAAQNAAKLLSHFRNTGA PVFHVQHITEGNIAHFFHPNTEGVEIHESVRPLEKETVIVKHMPNSFFNTDLNGKLQE EGVKELVVCGMMSHMCIDATVRSAVEHGYVCQVVEDACATTTLQIEDKIVPAEHVHYA FMAALNGVYATVKTTEAFLK*" gene 552616..553158 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" promotor_-35 553631..553635 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 553652..553671 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 553661 /Source="Nicolas_upshifts" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" CDS 553711..554475 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388389.1" /db_xref="EnsemblGenomes-Gn:BSU05080" /db_xref="EnsemblGenomes-Tr:CAB12315" /db_xref="GOA:P96655" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12125" /db_xref="UniProtKB/Swiss-Prot:P96655" /translation="MNITQIRNATIVVKYANKKFLIDPMLAEKGTYATFPETIRQDLF NPLVSLPTSIDNILDGVDAVIVTHLHLDHFDDVAKNVLPKNIKMFVQNEADAKEVKAS GFKNVEVLHQDTVFEGIQLVKTKGEHGRGEELLNLMGDVCGLVFKHPSEKVLYVAGDT VWYDAIEDEIHTHQPEIIVVNGGDNQRLDLGSLIMGKEDIYEVHKAAPHAKIISVHME AVNHWTLSREELKNFSKEKGFSSNILVPEDGESYTF*" gene 553711..554475 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" CDS 554669..555979 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388390.1" /db_xref="EnsemblGenomes-Gn:BSU05090" /db_xref="EnsemblGenomes-Tr:CAB12316" /db_xref="GOA:P96656" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12126" /db_xref="UniProtKB/Swiss-Prot:P96656" /translation="MVMTKKDTNISTQQPLWLQGYIDSPEKQNQLYKKTLKILIFSQI FGGAGLGAGITVGALLAQDMIGSENVAGIPTALFTFGSAVAALLIGASSQRFGRRAGL AGGFLIGGLGAIGVIIAALINSVALLFVSLLIYGAGMASNLQVRYAGTDLANEKQRAT AASMALVSTTLGAVVGPNLVNTMGEFADSIGVPNLAGPFIMSGAAFIIAGIILLIFLR PDPLFVSTAIANAEKKDDKVQIGGSLKNPAIDKKGIMVGAVIMILAQLIMTAIMTMTP VHMGHHGHGLSEVGLVIGLHIAAMYLPSPLTGLLVDKFGRTTMAIASGATLLAAGLVA AIAPADSLSLLILALVLLGVGWNFGLLTGTALIIDSTHPSLRAKTQGTFDVLLALSGA AGGALSGMVVAHSSYTILSISGAVLSLLLIPVVIWYFRRIQEKA*" gene 554669..555979 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" S_feature 556002..556561 /Source="Nicolas_S_feature" /locus_tag="new_556002_556561" /HighExp="S8, C30, Cold, BMM, C90, GM 25, MG 15, M/G, LPh, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S178" CDS 556562..556738 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved phage protein of unknown function" /protein_id="YP_003097682.1" /db_xref="EnsemblGenomes-Gn:BSU05099" /db_xref="EnsemblGenomes-Tr:CAX52553" /db_xref="GOA:Q9K3A9" /db_xref="UniProtKB/Swiss-Prot:Q9K3A9" /translation="MNNKKNIFDIVMYIIFGVLSLFLVAKTDYGTGVLVFVAILYLAV IAYKIKQVFSNSDS*" gene 556562..556738 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" CDS 556763..557449 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported phage protein" /protein_id="NP_388391.1" /db_xref="EnsemblGenomes-Gn:BSU05100" /db_xref="EnsemblGenomes-Tr:CAB12317" /db_xref="SubtiList:BG12127" /db_xref="UniProtKB/Swiss-Prot:P96657" /translation="MRKKRVITCVMAASLTLGSLLPAGYASAKEDSKTTPSYEELALH YKMKSEKISSNGKLVEIEYVSGNETHKVQMNGNNHTVKVDGIEQKGLNFEYDENVAKR TNYENNNLKSNEFTTQAAKPKKGYHYVGTLSGHTKAAKNALSVTMSLVGIVPGLGWGS KAATILFSYWAKEQIPDAYYKYDLYEKGAMTDSWYQYATVQFFEDKAHKKKMGKPWTS TPAKVDLPNS*" gene 556763..557449 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" promotor_-35 557791..557795 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-35" promotor_-10 557810..557829 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-10" upshifts 557818 /Source="Nicolas_upshifts" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" CDS 557873..558058 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097683.1" /db_xref="EnsemblGenomes-Gn:BSU05109" /db_xref="EnsemblGenomes-Tr:CAX52554" /db_xref="GOA:C0H3V7" /db_xref="UniProtKB/Swiss-Prot:C0H3V7" /translation="MRWSKWFNVFCIVALGSIYGYKLFTNQEVSTTRLIIASVIVLWN IVGLFSKESVKQAQQAN*" gene 557873..558058 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" downshifts 558057 /Source="Nicolas_upshifts" /id="D241" /incds=0 /nref=9 /ntot=125 /MaxReadThrough="3.39785" /MaxDrop="3.7067" /score="-6.31330934" /energy="-12.8" /TU="U394" /idTUdmin="U394" /TUdmin="-1068" /isTUend="FALSE" CDS 558408..559001 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" /experiment="publication(s) with functional evidences, PMID:24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase III homolog, deglycase" /protein_id="NP_388392.1" /db_xref="EnsemblGenomes-Gn:BSU05110" /db_xref="EnsemblGenomes-Tr:CAB12318" /db_xref="GOA:P96658" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="PDB:3F5D" /db_xref="SubtiList:BG12128" /db_xref="UniProtKB/Swiss-Prot:P96658" /translation="MKKALFLILDQYADWEGVYLASALNQREDWSVHTVSLDPIVSSI GGFKTSVDYIIGLEPANFNLLVMIGGDSWSNDNKKLLHFVKTAFQKNIPIAAICGAVD FLAKNGLLNNHSHTGNFVYLWKDYKQYKPISSFVEKQAVRDKNLVTANGTAPIEFTNL ILEMIDFDTPENIEKMMYMNRYGFYHFCDKYGNPFVD*" gene 558408..559001 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" promotor_-35 559114..559121 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 559135..559154 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 559146..559263 /Source="Nicolas_S_feature" /locus_tag="new_559146_559263" /HighExp="B60, LoTm, T5.0H, T3.30H, M9-stat, BI, BC, C90, T3.0H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S179" upshifts 559146 /Source="Nicolas_upshifts" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" downshifts complement(559181) /Source="Nicolas_upshifts" /id="D242" /incds=0 /nref=10 /ntot=93 /MaxReadThrough="1.86628" /MaxDrop="4.19111" /score="25.1917407" /energy="-12.9" /TU="NA" /idTUdmin="U396" /TUdmin=328 /isTUend="FALSE" CDS 559264..559464 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9379903, 9914312, 9920884, 10517332, 11591689, 12427936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379903, 9914312, 9920884, 10517332, 11591689, 12427936; Product type f : factor" /codon_start=1 /transl_table=11 /product="cold-shock protein" /protein_id="NP_388393.1" /db_xref="EnsemblGenomes-Gn:BSU05120" /db_xref="EnsemblGenomes-Tr:CAB12319" /db_xref="GOA:P39158" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11024" /db_xref="UniProtKB/Swiss-Prot:P39158" /translation="MEQGTVKWFNAEKGFGFIERENGDDVFVHFSAIQSDGFKSLDEG QKVSFDVEQGARGAQAANVQKA*" gene 559264..559464 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" S_feature complement(559362..560150) /Source="Nicolas_S_feature" /locus_tag="new_559362_560150_c" /HighExp="LoTm, B60, Cold, M9-stat, LPhT, B36, Sw, BC, S8, Salt" /AntisenseName="cspC" /AntisenseCor="0.39074308987975698" /AntisenseRegPval="-10.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S180" downshifts 559367 /Source="Nicolas_upshifts" /id="D243" /incds=1 /nref=19 /ntot=179 /MaxReadThrough="8.05368" /MaxDrop="3.4464" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=242 /isTUend="FALSE" downshifts 559468 /Source="Nicolas_upshifts" /id="D244" /incds=0 /nref=65 /ntot=246 /MaxReadThrough="5.78621" /MaxDrop="5.83905" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=343 /isTUend="FALSE" misc_RNA complement(559532..559610) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" /product="putative small conserved untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" gene complement(559532..559610) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" CDS complement(560151..560612) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26849219; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for repair and outgrowth of heat damaged spores" /protein_id="NP_388394.1" /db_xref="EnsemblGenomes-Gn:BSU05130" /db_xref="EnsemblGenomes-Tr:CAB12320" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG12129" /db_xref="UniProtKB/Swiss-Prot:P96659" /translation="MFQIGDNIVYPMHGAGIIEAIEEKEFLEEKQQYYVIRMSISNMT VMIPTSKILSSNIRPVTDILALKHIMHIFQHGESDRLLPWKQRYKINTDKIKTGEIQE GAEVVRDLMRMKKEKALNASEKKMLDNAYEFLISELEVIKGITEKQIKSFG*" gene complement(560151..560612) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" S_feature 560621..561166 /Source="Nicolas_S_feature" /locus_tag="new_560621_561166" /HighExp="Cold, G135, S8, G180, LoTm, S7, G150, HPh, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S181" upshifts complement(560664) /Source="Nicolas_upshifts" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" promotor_-10 complement(560671..560690) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(560706..560713) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 561133 /Source="Nicolas_upshifts" /id="D245" /incds=0 /nref=7 /ntot=141 /MaxReadThrough="0.289110000000001" /MaxDrop="4.3701" /score="26.1823933" /energy="-9.5" /TU="NA" /idTUdmin="U395" /TUdmin=864 /isTUend="FALSE" CDS complement(561180..561416) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388395.1" /db_xref="EnsemblGenomes-Gn:BSU05140" /db_xref="EnsemblGenomes-Tr:CAB12321" /db_xref="GOA:O31493" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12808" /db_xref="UniProtKB/Swiss-Prot:O31493" /translation="MYLGIVSTACAFLLWNHGLQLLNASSGGLFFFFQPLVGTLLGWI LLGEQIGGTFWIGSFLILSGVLLVIKEKEKEVKS*" gene complement(561180..561416) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" CDS complement(561514..562389) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388396.1" /db_xref="EnsemblGenomes-Gn:BSU05150" /db_xref="EnsemblGenomes-Tr:CAB12322" /db_xref="GOA:P96660" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG12130" /db_xref="UniProtKB/Swiss-Prot:P96660" /translation="MKNFVIDQNLKELTEHRTVELPVACYKTTINQNINGYIPLHWHD EIQFVLILKGIALFQINEEKIEVHEGDGLFINSGYLHMAEEKEGSDCTYICLNVSPHF VLSQELYSSYVQPYMFSTNLPYLFLAGNQQWAKNILDAVKKINQLIQQKTSLYEIDIT MQLTLMWKNLVVNGFQLEYDQSEMIKSHRMKQMLNWIHLHYVEKITLEDIAKAGQLSR SECCRYFKRMLNKTPLRYVMDYRIQKSLLLLQHPESNVTEVSYQVGFNSTSYFISKFQ QAMNMTPLSYKKMNS*" gene complement(561514..562389) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" CDS 562502..563461 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388397.1" /db_xref="EnsemblGenomes-Gn:BSU05160" /db_xref="EnsemblGenomes-Tr:CAB12323" /db_xref="GOA:P96661" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12131" /db_xref="UniProtKB/Swiss-Prot:P96661" /translation="MNTSNRRMGLFYVITGATCWGIGGTVAKKLFQEYQIDVNWLVTT RLLTAGMLLLMLQLFRKDRSQVIEVWKHKASAGQLLIFGLLGMLAVQYTYMASIQHGN AAVATLLQYLSPVIVIIYTLLRKQTVLTKQDIITVVLALVGCFFLLTNGSMSQLSVPA AAVVWGVLSGFAAAFYTLYAVGLLNKFDSLVVVGWAMIIGGFALGFIHPPWQLDFQRL TAEAYAYILFVILFGTMIAFWFFIKSLESLSPKETSLLGSLEPLSAVVTTVVWLKAPF GSFQWIGAICIIGITLILALHKEPSMESEKSILKIRNHANRDI*" gene 562502..563461 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" upshifts complement(562523) /Source="Nicolas_upshifts" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" misc_feature complement(562527..562546) /Source="Nicolas_upshift_promotors" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(563614..564486) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388398.1" /db_xref="EnsemblGenomes-Gn:BSU05170" /db_xref="EnsemblGenomes-Tr:CAB12324" /db_xref="GOA:P96662" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12132" /db_xref="UniProtKB/Swiss-Prot:P96662" /translation="MDLLKSMNRALKYIEENLTNDIDFQEAAKLAFCSEYHFKRMFSF LAGISLSEYIRRRRLTLAAFELKDSNVKVIDIAIKYGYNSPDSFARAFQNLHGINPSK ARFNGHSLKAYPRMTFQLTIKGGNEMNYRIEEKEAFRIVGIKKRVPIIFKGINPEIAS MWESLDEKAINKLKELSNVAPSGLISASTNFSEGRTEENGELDHYIGAATTKRCPDNF SRLEVPASTWAVFESIGPFPDTLQEVWGRIYSEWFPSSNYEQIEGPEILWNEHKDVTS PSFKSEIWIPITKK*" gene complement(563614..564486) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" promotor_-10 complement(564579..564584) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(564586..564587) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(564591) /Source="Nicolas_upshifts" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 564660..564666 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 564674 /Source="Nicolas_upshifts" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" promotor_-10 564680..564699 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 564713..566101 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388399.2" /db_xref="EnsemblGenomes-Gn:BSU05180" /db_xref="EnsemblGenomes-Tr:CAB12325" /db_xref="GOA:P96663" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12133" /db_xref="UniProtKB/Swiss-Prot:P96663" /translation="MPINSFENYPMSWKPSIDKAEKPIYKALAGQLEQDILNGVLLPG TKLPPQRELADYLDLNVSTISKAFKVCELKGLLSATVGSGTFVSYDALSNAYLLEDTK PTHLIEMGAILPDHASYEPLLYQLKNMVHEEDYEKWFSYGRAGESLWQKDAAVKLIQR GGFETSVDHILFANGGQNAIAATLASLCKPGDRIGVDHHTYPGLKTVASLLSVQIVPI KSENDEMSPESLEYACKNENIKGLYLIPDYHNPTTSFMSVENRRMVADIVKKYNLFVI EDASYHLLNKNPLPALASFAPQQVIHIASLSKSLAPGLRLAYVAVPRQYKEPISKALY NLNITVSPLLAELTARTIVSNQFEVLIESHREQTIRRNQLVNRYVAGYTCLGVETGIF RWLLLPGKMSGAEFEELAARLGVQVYAAERFVVGNSCPERAVRVSVCAPKTLEELEQG LMILRRLLDDLT*" gene 564713..566101 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" downshifts 566077 /Source="Nicolas_upshifts" /id="D246" /incds=0 /nref=2 /ntot=61 /MaxReadThrough="0.91547" /MaxDrop="3.65963" /score="12.298375" /energy="-12.2" /TU="NA" /idTUdmin="U399" /TUdmin=176 /isTUend="FALSE" CDS 566211..567503 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388400.1" /db_xref="EnsemblGenomes-Gn:BSU05190" /db_xref="EnsemblGenomes-Tr:CAB12326" /db_xref="GOA:P96664" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12134" /db_xref="UniProtKB/Swiss-Prot:P96664" /translation="MMLDKDSVKAIDVQTASLQSYISSPEKQKSLYKRTLFVVSISQI FGGAGLAAGVTVGALIAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGL SAGFMIGGLGAIGVIMAAIINSIFLLFISLLIYGAGTATNLQARYAGTDLANHKQRAT AVSITMVFTTFGAVAGPSLVNVMGDFALSIGVPSLAGPFILAAAAYMLAGVVLFIMLR PDPLVIARTIEAANEEPGDKGHLAATEHTENKKGIIVGATVMVLTQIVMVAIMTMTPV HMRHHGHDLGAVGLVIGFHIGAMYLPSLVTGVLVDRLGRTAMAISSGTTLLLAGVIAA FAPGESMILLVIALSLLGLGWNFGLISGTALIVDSTDTATRAKTQGTVDVLIALSGAA GGALSGMIVAGSSYLALSLIGGILSLLLIPVVVWSRGR*" gene 566211..567503 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" promotor_-35 567512..567518 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 567533..567552 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 567540 /Source="Nicolas_upshifts" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" S_feature 567551..567661 /Source="Nicolas_S_feature" /locus_tag="new_567551_567661" /HighExp="LoTm, T4.0H, T3.30H, T2.30H, T3.0H, T2.0H, T1.30H, T5.0H, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S182" CDS 567662..568108 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388401.1" /db_xref="EnsemblGenomes-Gn:BSU05200" /db_xref="EnsemblGenomes-Tr:CAB12327" /db_xref="GOA:P96665" /db_xref="SubtiList:BG12135" /db_xref="UniProtKB/Swiss-Prot:P96665" /translation="MNHIKWLSDLKKAGLLALGKGVITLLKRFSLVIVTLMMSIVVVL AAAKESPGDHVISFDEPIILMISIGIVVFLLIPPLVMSFFGNLVVRIISGVYQCFIVF TFLGLIPIGFLIPNGFLTILVSIAGTLVSIASVAVTLCIGKNKKDI*" gene 567662..568108 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" downshifts 568137 /Source="Nicolas_upshifts" /id="D247" /incds=0 /nref=200 /ntot=251 /MaxReadThrough="2.56495" /MaxDrop="6.50538" /score="-1.7193297" /energy="-4.5" /TU="NA" /idTUdmin="U400" /TUdmin="-8" /isTUend="TRUE" promotor_-35 568188..568195 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 568210..568229 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 568211 /Source="Nicolas_upshifts" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" CDS 568345..568938 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16390439" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388402.1" /db_xref="EnsemblGenomes-Gn:BSU05210" /db_xref="EnsemblGenomes-Tr:CAB12328" /db_xref="InterPro:IPR014922" /db_xref="InterPro:IPR016786" /db_xref="SubtiList:BG12136" /db_xref="UniProtKB/Swiss-Prot:P96666" /translation="MTNSRTNPKVDEFLSKAKKWKEEFEKLRTIILDCELTEDFKWMH PCYTYHNKNIVLIHGFKEYCALLFHKGVLLQDTDGILIQQTENVQAARQIRFTNVQEI NELENILKAYIHEAIEVEKAGLKVDVNKNIELNIPEELQNKFDEIPALKIAFEALTPG RQRAYTLYFSQAKQSKTRESRVEKYVQKILDGKGLKD*" gene 568345..568938 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" downshifts 568981 /Source="Nicolas_upshifts" /id="D248" /incds=0 /nref=2 /ntot=40 /MaxReadThrough="1.63432" /MaxDrop="2.96785" /score="2.93671425" /energy="-6.9" /TU="NA" /idTUdmin="U401" /TUdmin=0 /isTUend="TRUE" downshifts complement(569057) /Source="Nicolas_upshifts" /id="D249" /incds=0 /nref=1 /ntot=64 /MaxReadThrough="2.19009" /MaxDrop="2.9369" /score="-1.28013562" /energy="-6.9" /TU="NA" /idTUdmin="U403" /TUdmin=0 /isTUend="TRUE" promotor_-35 569070..569077 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 569091 /Source="Nicolas_upshifts" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 569092..569111 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(569290..569949) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388403.1" /db_xref="EnsemblGenomes-Gn:BSU05220" /db_xref="EnsemblGenomes-Tr:CAB12329" /db_xref="GOA:P96667" /db_xref="SubtiList:BG12137" /db_xref="UniProtKB/Swiss-Prot:P96667" /translation="MKKRRKICYCNTALLLMILLAGCTDSKDGEAQQPSNQASAVQTD EKHTEPEESTKIRKDEAEPITESEESATKAANDTSSAEEKSKEDNVLAAYSSEKIEYA RVWLQLGPNQEIDELNVRHIAAGEPINPNDDTSASYPENVTQLAGSRLVDGSVTYHGN GDGTIHVYNVPLRWDSADDIEKGVMREVTESIIKNRKTVYVDTGDDEKIKRLIDIMMI H*" gene complement(569290..569949) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" promotor_-10 complement(569998..570017) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(570005) /Source="Nicolas_upshifts" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" promotor_-35 complement(570029..570034) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(570371..571234) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388404.1" /db_xref="EnsemblGenomes-Gn:BSU05230" /db_xref="EnsemblGenomes-Tr:CAB12330" /db_xref="GOA:P96668" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12138" /db_xref="UniProtKB/Swiss-Prot:P96668" /translation="MNKTTNGWINGFIGVLIFSGSLPATRLAVSDFDPLFLTVCRAAI AGVLAGGLLLIFRQQHPAKRDLISLLVVAFGVVIGFPLLTALALQHVTSAHAIVFIGL LPLATAVFGVLRGGERPRPVFWIFSAAGSLLVAGFALIQGGGSSPLGDAYMLASIVVC GLGYAEGAKLSRRLGNWQVISWALVLSLPLMLPLSFFFTPDSWSAIGVPALLSLAYVS LFSMLIGFVFWYRGLAQGGIAAVGQLQLLQPFFGLLLASVILHEKVGWALVAVNIAVI MCVAAARRFAK*" gene complement(570371..571234) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" promotor_-35 571277..571283 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 571298..571317 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(571299..571318) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 571313 /Source="Nicolas_upshifts" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(571323) /Source="Nicolas_upshifts" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(571333..571340) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 571389..572780 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" /function="16.3: Control" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388405.1" /db_xref="EnsemblGenomes-Gn:BSU05240" /db_xref="EnsemblGenomes-Tr:CAB12331" /db_xref="GOA:P96669" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12139" /db_xref="UniProtKB/Swiss-Prot:P96669" /translation="MDITPFLNRTLDIPLYQQLYRYFKENMHRGRIQKGMKLPSKRLL ANQLSISQTTVERAYEQLAAEGYIVSKPRSGWFADYHDSDFAYDRMPSTTPIQQEAEE NKQWIDFHYGNVDSSYFPFSAWRKSMVNSLDQYGHELYRPGHVLGEFELRTLIAEYLY QSRGVHCGPEQVIIGAGNPILLQILCQVFEPNISIGYEDPGYPRARKIFEANRMNIVP IPVDDEGICIQKIKEQQPNLVYVTPSHQFTLGTIMTINRRIQLLKWAAENQSFIIEDD YDGEFRYTGQPVPSLQGLDQHNRVIYMGTFSKSLLPSLRISYMILPSPLLKKGHEITS LYKQTVSCHSQLTLAEFIKNGEWQKHINRMRKLYRKKRAIVLEAVQRELGEHVRIRGE NSGLRILLDVYLPFGEKELIEKAKKHGVKIYPVSLSYQHHPPTKTVSLGFAGVSESDI REGIKKLKAAWKI*" gene 571389..572780 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" promotor_-35 572908..572915 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-35" promotor_-10 572926..572945 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-10" upshifts 572940 /Source="Nicolas_upshifts" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" CDS 572974..573399 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1556068, 26349822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase" /protein_id="NP_388406.1" /db_xref="EnsemblGenomes-Gn:BSU05250" /db_xref="EnsemblGenomes-Tr:CAB12332" /db_xref="InterPro:IPR002539" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12140" /db_xref="UniProtKB/Swiss-Prot:P96670" /translation="MKLDEFTIGQVFKTKSLKVSKDDIMRFAGEFDPQYMHVDEEKAS KGRFNGIIASGIQTLAISFKLWIEEGFYGDDIIAGTEMNHMTFIKPVYPDDELFTIVE VLDKQPKRNELGILTVLLSTYNQKEVKVFEGELSVLIKR*" gene 572974..573399 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" S_feature 573400..574654 /Source="Nicolas_S_feature" /locus_tag="new_573400_574654" /HighExp="G135, H2O2, G150, HiOs, G180, Cold, Paraq, UNK1, MG 15, LBGexp" /AntisenseName="ydeN" /AntisenseCor="0.40423774227585801" /AntisenseRegPval="-11.3" /CDS_PredictionProba="0.127641" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S183" CDS complement(573452..574024) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15159570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alpha/beta hydrolase" /protein_id="NP_388407.1" /db_xref="EnsemblGenomes-Gn:BSU05260" /db_xref="EnsemblGenomes-Tr:CAB12333" /db_xref="GOA:P96671" /db_xref="InterPro:IPR010662" /db_xref="InterPro:IPR029058" /db_xref="PDB:1UXO" /db_xref="SubtiList:BG12141" /db_xref="UniProtKB/Swiss-Prot:P96671" /translation="MTKQVYIIHGYRASSTNHWFPWLKKRLLADGVQADILNMPNPLQ PRLEDWLDTLSLYQHTLHENTYLVAHSLGCPAILRFLEHLQLRKQLGGIILVSGFAKS LPTLQMLDEFTQGSFDHQKIIESAKHRAVIASKDDQIVPFSFSKDLAQQIDAALYEVQ HGGHFLEDEGFTSLPIVYDVLTSYFSKETR*" gene complement(573452..574024) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" downshifts complement(573457) /Source="Nicolas_upshifts" /id="D250" /incds=0 /nref=16 /ntot=160 /MaxReadThrough="1.96868" /MaxDrop="3.80195" /score="2.50673989" /energy="-11.3" /TU="NA" /idTUdmin="U407" /TUdmin=0 /isTUend="TRUE" S_feature complement(574025..574105) /Source="Nicolas_S_feature" /locus_tag="new_574025_574105_c" /HighExp="dia15, dia5, Diami, Etha, LPhT, Lbtran, Heat, H2O2, Sw, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S184" CDS complement(574106..574435) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388408.1" /db_xref="EnsemblGenomes-Gn:BSU05270" /db_xref="EnsemblGenomes-Tr:CAB12334" /db_xref="GOA:O31494" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12809" /db_xref="UniProtKB/Swiss-Prot:O31494" /translation="MNSLCRSKQAPFEYTLSLIGGKWKMRILYELGCEKTMRYGELKR AMPFITHKMLSAQLKELQTDGLIHRSEVSHTPLKVEYSLSDRGRSLYPLIDEMCKWGM AQGGPHM*" gene complement(574106..574435) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" misc_feature complement(574452..574471) /Source="Nicolas_upshift_promotors" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(574469) /Source="Nicolas_upshifts" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" misc_feature 574643..574662 /Source="Nicolas_upshift_promotors" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 574656 /Source="Nicolas_upshifts" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" CDS 574690..575562 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388409.1" /db_xref="EnsemblGenomes-Gn:BSU05280" /db_xref="EnsemblGenomes-Tr:CAB12335" /db_xref="GOA:P96672" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12142" /db_xref="UniProtKB/Swiss-Prot:P96672" /translation="MNTPKKHKKFKAKMILQIIMVIIGGIIAAYGLETVLIPNSVSDG GVTGLSIVGSQLFNLPLGILIAVINIPFVWLGYKQIGKSFALLSIIGIVSLAAGTSFF HHTPAIIEGDTLLITVVGGIILGFGMGLALRNGGALDGIDMLAVLLSRKLPFGTSDLI LFLNLFVFIFVSTVFGLQGALLSVIAYYIASKVIHVVEEGLSGSKTFQIITTQPELMV ETIRDQLGRSATYKEAYGGFSHEKFKEITCVINRLEETKLKEIINDIDKTAFVTVYDV AEVKGSNFRNLNHH*" gene 574690..575562 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" downshifts 575449 /Source="Nicolas_upshifts" /id="D251" /incds=1 /nref=7 /ntot=181 /MaxReadThrough="3.84278" /MaxDrop="2.68681" /score="15.0132064" /energy="-12.2" /TU="U408" /idTUdmin="U408" /TUdmin="-198" /isTUend="FALSE" downshifts 575647 /Source="Nicolas_upshifts" /id="D252" /incds=0 /nref=54 /ntot=208 /MaxReadThrough="1.19842" /MaxDrop="3.77294" /score="15.0132064" /energy="-12.2" /TU="NA" /idTUdmin="U408" /TUdmin=0 /isTUend="TRUE" CDS complement(575712..576098) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388410.1" /db_xref="EnsemblGenomes-Gn:BSU05290" /db_xref="EnsemblGenomes-Tr:CAB12336" /db_xref="GOA:P96673" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12143" /db_xref="UniProtKB/Swiss-Prot:P96673" /translation="MRNRKLGIDYSSDDFEGCPVETTLDIIGGKWKGILLYHLIDGKK RFNEFRKLYPKITQRMLTLQLRELERDGVIHREVYKQVPPKVEYSLTEFGRTLEPVIL HMKDWGEKYKDRIDKLEAARKAEDKI*" gene complement(575712..576098) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" downshifts complement(575724) /Source="Nicolas_upshifts" /id="D253" /incds=0 /nref=29 /ntot=191 /MaxReadThrough="0.85093" /MaxDrop="4.4837" /score="-9.3516261" /energy="-12.9" /TU="NA" /idTUdmin="U409" /TUdmin="-1" /isTUend="TRUE" S_feature complement(576099..576163) /Source="Nicolas_S_feature" /locus_tag="new_576099_576163_c" /HighExp="Diami, dia5, Salt, dia15, Etha, Heat, G180, HiOs, LBGexp, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S185" promotor_-35 576151..576158 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(576152..576171) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(576165) /Source="Nicolas_upshifts" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" promotor_-10 576172..576191 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 576175 /Source="Nicolas_upshifts" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" promotor_-35 complement(576186..576193) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 576209..576802 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" /EC_number="1.6.99.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase involved in regulating potassium efflux" /protein_id="NP_388411.1" /db_xref="EnsemblGenomes-Gn:BSU05300" /db_xref="EnsemblGenomes-Tr:CAB12337" /db_xref="GOA:P96674" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12144" /db_xref="UniProtKB/Swiss-Prot:P96674" /translation="MDHMKTLVLVVHPNIESSRINKKWKEAVLSEPDVTVHDLYEKYR DQPIDVEFEQQQLLAHDRIVFQFPLYWYSSPPLLKQWFDEVFTFGWAHGPGGNKLKGK EWVTAMSIGSPEHSYQAGGYNLFSISELTKPFQASAHLVGMTYLPSFAEYRANTISDQ EIAESANRYVKHITNIELNPKVRLQRYLKQLESVDLT*" gene 576209..576802 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" CDS complement(576946..578133) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388412.1" /db_xref="EnsemblGenomes-Gn:BSU05310" /db_xref="EnsemblGenomes-Tr:CAB12338" /db_xref="GOA:P96675" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12145" /db_xref="UniProtKB/Swiss-Prot:P96675" /translation="MANGNKQAGQRISPSLTLLLATACGIIVANLYYAQPLVGLISKA IGLSPSGAGLIVTLTQIGYVAGLLFLVPLGDIIENKKLIVVSLLLSAAALTLTAFVKH GTLFLAAAFFVGLGSIAAQVLVPFASYLASDAARGRVVGNVMSGLLLGIMLSRPISSL VADIWGWNAIFALSAVVSVILAIVLSKVLPARKPTANTNYTALLGSMWKLLRTTPVLR RRAIYHAFVFGAFSLFWTTVPLLLSGPDFHFSQKAIALYALVGIAGAVTAPIGGRLAD RGLTRLATGIALGVVVVSLLLPLMIQSSSPVGITVLVAAAILLDMGVSANLVLSQRAI FSLAPEIRSRLNGLFMAIFFLGGAIGSSIGGWAYASGGWSTALWIGIAFPVIALLYFI TEK*" gene complement(576946..578133) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" promotor_-35 578269..578273 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 578287 /Source="Nicolas_upshifts" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" promotor_-10 578288..578307 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 578337..578933 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15944459; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388413.1" /db_xref="EnsemblGenomes-Gn:BSU05320" /db_xref="EnsemblGenomes-Tr:CAB12339" /db_xref="GOA:P96676" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011075" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12146" /db_xref="UniProtKB/Swiss-Prot:P96676" /translation="MQSKRGRPRDEGTHKAILSAAYDLLLEKGFDAVTVDKIAERAKV SKATIYKWWSNKAAVIMDSFLSTATDRLPVPDTGSSVQDIVTHATNLARFLTSREGTV IKELIGAGQLDEKLAEEYRTRFFQPRRLQAKGLLEKGIQKGELRENLDIEVSIDLIYG PIFYRLLITGDEVNDSYVRDLVMNAFKGVQATSATESM*" gene 578337..578933 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" CDS 579047..579232 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097684.1" /db_xref="EnsemblGenomes-Gn:BSU05329" /db_xref="EnsemblGenomes-Tr:CAX52555" /db_xref="UniProtKB/Swiss-Prot:C0H3V9" /translation="MSKKKSFNREYITSYYYIPFHRLEQGFYTSMEYRKVGVFKQQGK IDGHYVGVMAMEKILAM*" gene 579047..579232 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" downshifts 579211 /Source="Nicolas_upshifts" /id="D254" /incds=0 /nref=5 /ntot=123 /MaxReadThrough="1.06987" /MaxDrop="2.89833" /score="-5.04743481" /energy="-6.3" /TU="NA" /idTUdmin="U411" /TUdmin=0 /isTUend="TRUE" promotor_-35 579344..579347 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 579354..579540 /Source="Nicolas_S_feature" /locus_tag="new_579354_579540" /HighExp="LBGstat, G180, LBGexp, G135, Paraq, G150, Oxctl, dia0, Diami, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S186" upshifts 579354 /Source="Nicolas_upshifts" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" promotor_-10 579362..579381 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 579541..579876 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15948947, 16430705" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16430705; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (metals sensing ArsR-SmtB repressors family)" /protein_id="NP_388414.1" /db_xref="EnsemblGenomes-Gn:BSU05330" /db_xref="EnsemblGenomes-Tr:CAB12340" /db_xref="GOA:P96677" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12147" /db_xref="UniProtKB/Swiss-Prot:P96677" /translation="MTIDVAAMTRCLKTLSDQTRLIMMRLFLEQEYCVCQLVDMFEMS QPAISQHLRKLKNAGFVNEDRRGQWRYYSINGSCPEFDTLQLILHQIDQEDELLNHIK QKKTQACCQ*" gene 579541..579876 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" CDS 579889..581196 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12950922, 14970228, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arsenite/antimonite/H+ antiporter" /protein_id="NP_388415.1" /db_xref="EnsemblGenomes-Gn:BSU05340" /db_xref="EnsemblGenomes-Tr:CAB12341" /db_xref="GOA:P96678" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12148" /db_xref="UniProtKB/Swiss-Prot:P96678" /translation="MTSMILAVFIFLLTLVLVIWQPKNLSIGWSACGGAVLALIAGVV NFHDVLTVTGIVWNATLAFVAIILISLILDNIGFFEWAALHMAKAAKGYGVRMFVYVS LLGAIVAALFANDGAALILTPIVLAMVRALHFNEKLVFPFIIASGFIADTTSLPFVVS NLVNIVSADYFHITFIDYASRMVVPYLFSLLASIIVLYLFFRKSIPKRYDLTEVKKPV EAIKDQNMFRLSWYILGLLLIGYFASEFFSIPVSVVAGSIAIIFLIAAQKSPAVHTKK VVKEAPWAIVFFSIGMYVVVYGVRNAGLTDVLSDVIQAAADQGLFAGTIGMGFIAAIL SSIMNNLPTVMIDALAIAGTDTHGMMREALIYANVIGSDLGPKITPIGSLATLLWLHV LSHKGMKISWGTYFKTGIILTIPTLLITLVGLYIWLLIIHSCF*" gene 579889..581196 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" CDS 581228..581332 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; N-terminal part of ydzS" /translation="CTGNSCRSQMAEGWGRKYLGAKWNVYSAGIEAQG*" gene 581228..581332 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /pseudo CDS 581341..581454 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; C-terminal part of ydzS" /translation="AVKAMKEAGIDISNQTSEKFDDPAKAHGTEEVFPKGP*" gene 581341..581454 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /pseudo promotor_-35 581640..581648 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 581659..581677 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 581676 /Source="Nicolas_upshifts" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 581694..582479 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388416.1" /db_xref="EnsemblGenomes-Gn:BSU05350" /db_xref="EnsemblGenomes-Tr:CAB12342" /db_xref="GOA:P96679" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR027365" /db_xref="SubtiList:BG12149" /db_xref="UniProtKB/Swiss-Prot:P96679" /translation="MSVLQELTKKKYSSLKTMFDDKYCPTFVYSILDQTIPGAVYADD QTFPKSFFIGTESGIYFIAGDQGNRDFHDFIAGYYEEQVKSSKRFTLFSSSDTWDSVL KPILKDDLNQMRRAAFSYQPKSFKKTLQLPKGLVLKRIDEDIISHSTAFNSAYYEEYW NSVSQFASKGFGFAVLHGNHVVSECTSIFLGHNRAEMDIYTLEEYRGLGLAYCVANRF IAFCMENGIVPSWDCDICNNSSIALAAKLGFKTVTEYTIYYSG*" gene 581694..582479 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" downshifts 581741 /Source="Nicolas_upshifts" /id="D255" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="2.67554" /MaxDrop="5.08398" /score="39.1565399" /energy="-19.2" /TU="NA" /idTUdmin="U413" /TUdmin=0 /isTUend="TRUE" downshifts 582489 /Source="Nicolas_upshifts" /id="D256" /incds=0 /nref=2 /ntot=90 /MaxReadThrough="0.161840000000001" /MaxDrop="3.51451" /score="-0.169292431" /energy="-13.6" /TU="NA" /idTUdmin="U413" /TUdmin=748 /isTUend="FALSE" CDS complement(582536..583456) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid exporter" /protein_id="NP_388417.1" /db_xref="EnsemblGenomes-Gn:BSU05360" /db_xref="EnsemblGenomes-Tr:CAB12343" /db_xref="GOA:P96680" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12150" /db_xref="UniProtKB/Swiss-Prot:P96680" /translation="MRKKTVQIMISHSLMIGLWASAFPGIRAGLEGYTPEHLALFRLL IGSMALLLFAVLTQMRLPDLKDIPAIFLLGFLGFAFYHILLNIGEKTVSAGVASLLVT TAPIFSAMLSRLFYKEHFGFTKWLGSMISLLGVLLIAFGAGDFTYSMSGILVILLAAF SESIYFVFQARYIKKYGFIPFVTFTIWGGTIPMLVFLPGLGEEMMNASISATLSIVYL GLLPTVIPYFALAYVTSFVGASEATLSLYVTPALALIISWLWIGEIPTLLSLLGGVVT VGGVCFTYLKVNKMNKIFITHFSAKRVKKL*" gene complement(582536..583456) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" CDS 583589..585037 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388418.1" /db_xref="EnsemblGenomes-Gn:BSU05370" /db_xref="EnsemblGenomes-Tr:CAB12344" /db_xref="GOA:P96681" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12151" /db_xref="UniProtKB/Swiss-Prot:P96681" /translation="MSFPEEKKMKKLPKYRQIVHFIKEKIGNGEWPIGSKIPSQRTLA KDFQVNRSTVITALEELMADGLIEGTMGKGTVVINNTWTLMAKNSAPDWDQYVTSGIQ MPSRKIVQEINQSESNTDLIQLSKGELSAEIFPLAVMKEMMGKVSQHMEAFGYEEPKG YLPLREALSNYLKTIGINVSSSSILIVSGALQALQLISMGLLQRGSTVYLDQPSYLYS LHVFQSAGMKLTGLPMDNEGLLPENVHLTRGERGRAILYTNPCFHNPTGILMSKKRRE EILAVSENTQLPIIEDDIYRELWIDEIPPYPIKTIDKNGHVLYIGSLSKTLSPGLRIG WIVGPEPVIERLSDIKMQTDYGSSSLSQRVAAEWFTSGHYQQHVEKVRQQLKVRRELA LSALETHLKEVATWNIPKGGFFVWIKILPSISMKLLYTKALSKGILINLGSIYAQEKG NYIRLSYAYASLEDLQKGIYELGLMIKELASR*" gene 583589..585037 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" CDS complement(585155..585778) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavoprotein" /protein_id="NP_388419.1" /db_xref="EnsemblGenomes-Gn:BSU05380" /db_xref="EnsemblGenomes-Tr:CAB12345" /db_xref="GOA:P96682" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12152" /db_xref="UniProtKB/Swiss-Prot:P96682" /translation="MDIKKQDTRRFKEIKPKIMYYGTSTFLLTTLNEDGTTNISPMSS SWALGHYIILGVGLGGKAIDNLERHKECVINLPGPDLWENVERISSYSGKKSIPPLKK QIGFTYKKEKYEAAGLTPLQSKTVSPTRIKECPIQIEAEVKHIRLPEYESSFAIVETQ ALHFHAEESIILDENHINPSKWSPLIYNFRHYFGLGREVGKTFRSET*" gene complement(585155..585778) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" promotor_-10 complement(585802..585821) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 585810..585817 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(585821) /Source="Nicolas_upshifts" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" promotor_-10 585832..585851 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 585834 /Source="Nicolas_upshifts" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" promotor_-35 complement(585836..585842) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 585868..586548 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388420.1" /db_xref="EnsemblGenomes-Gn:BSU05390" /db_xref="EnsemblGenomes-Tr:CAB12346" /db_xref="GOA:P96683" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12153" /db_xref="UniProtKB/Swiss-Prot:P96683" /translation="MNPNIAKISSLLSDPSRSSILLSLMDGRIHPAGELAYLANIKPQ TASFHLNKLLEAKLISVEKHGRHRYYRLADSDAANVIEQLLHIAPKAKVKSLKESKEK KDLHFARTCYDHLAGYVGVQMAHSLVEQGMLKKVDLNFEVTSEGALFFSKLGINEEQQ RNKRRAFARCCLDWSERQHHIAGALGNALLVRMLEEEWIVRMPKTRAIRITQSGKIAF EKHLNVKI*" gene 585868..586548 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" downshifts 586581 /Source="Nicolas_upshifts" /id="D257" /incds=0 /nref=113 /ntot=245 /MaxReadThrough="0.50202" /MaxDrop="4.24716" /score="-7.74889591" /energy="-4.5" /TU="U415" /idTUdmin="U415" /TUdmin="-22" /isTUend="TRUE" CDS complement(586628..587071) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388421.1" /db_xref="EnsemblGenomes-Gn:BSU05400" /db_xref="EnsemblGenomes-Tr:CAB12347" /db_xref="GOA:P96684" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR004675" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG12154" /db_xref="UniProtKB/Swiss-Prot:P96684" /translation="MSQRVSYYEIAPEGMKIMMDMEKYTKQSSINRTTRELIKIRVSQ MNGCAFCIDMHTSDARKMGETEQRIYCLHAWNECDFYSPEEKAALELSEHITLIPSKR VPDELYHRVREHYDEEQYVDLVLIINQINSWNRISIAMGNRAASK*" gene complement(586628..587071) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" downshifts complement(586633) /Source="Nicolas_upshifts" /id="D258" /incds=0 /nref=10 /ntot=187 /MaxReadThrough="1.76648" /MaxDrop="3.73786" /score="0.225628164" /energy="-10.8" /TU="NA" /idTUdmin="U416" /TUdmin=2 /isTUend="TRUE" promotor_-10 complement(587094..587113) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(587118) /Source="Nicolas_upshifts" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" promotor_-35 complement(587127..587134) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(587157..587336) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097685.1" /db_xref="EnsemblGenomes-Gn:BSU05408" /db_xref="EnsemblGenomes-Tr:CAX52558" /db_xref="GOA:C0H3W0" /db_xref="UniProtKB/Swiss-Prot:C0H3W0" /translation="MNMYWFLGALLYFLIGTYIFIRVTRDSQSGSWILLALAAPLIIA GYPYFYSKKLLSKRR*" gene complement(587157..587336) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" CDS complement(587333..587476) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097686.1" /db_xref="EnsemblGenomes-Gn:BSU05409" /db_xref="EnsemblGenomes-Tr:CAX52559" /db_xref="UniProtKB/Swiss-Prot:C0H3W1" /translation="MKSIDLTILSLKRKGIRTEKVLKNQNPDRLSHMTDKNAQPKSKE KEE*" gene complement(587333..587476) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" promotor_-35 587427..587429 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 587445..587464 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 587461 /Source="Nicolas_upshifts" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 587744..588967 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YdfI]" /protein_id="NP_388422.1" /db_xref="EnsemblGenomes-Gn:BSU05410" /db_xref="EnsemblGenomes-Tr:CAB12348" /db_xref="GOA:P96685" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12155" /db_xref="UniProtKB/Swiss-Prot:P96685" /translation="MLIRNPFKDKYYSHDRRALNMLALRVPGLAFILMIYIASIVLQF VSGGWSILLLYAFTILIAIFALLHWHSYRWVKKRVILYFAVQGLITFALANLMTGFFI LVIIGLYAFLIGQIIGMADRRRTFLILYLLLLLVINSAYHLHKGEVLHFIVIAAPIMI VIITYAATFFAQVDEKIKAQLTLERLELAHQQVEQLTLQNERQRMARDLHDTLAQGLV SLNMQLDAIHVHLAKGNTERAKEIIQQSMKRVKSTIADARSAIDDLRSKSEEIGVLKE RITSLMDHFIESTGMACLLDYRLHQVLDVRTAENCYYIIGECMTNAAKHAEAKTIWIS IWDDEKGRLHLTVKDNGKGFDVEKGKKKRGHYGLLGIQERVRAINGQFNIKSTKLKGT QIEITVPIQGEMQDE*" gene 587744..588967 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" CDS 588960..589601 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YdfH]" /protein_id="NP_388423.1" /db_xref="EnsemblGenomes-Gn:BSU05420" /db_xref="EnsemblGenomes-Tr:CAB12349" /db_xref="GOA:P96686" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12156" /db_xref="UniProtKB/Swiss-Prot:P96686" /translation="MNKVLIVDDHLVVREGLKLLIETNDQYTIIGEAENGKVAVRLAD ELEPDIILMDLYMPEMSGLEAIKQIKEKHDTPIIILTTYNEDHLMIEGIELGAKGYLL KDTSSETLFHTMDAAIRGNVLLQPDILKRLQEIQFERMKKQRNETQLTEKEVIVLKAI AKGLKSKAIAFDLGVSERTVKSRLTSIYNKLGANSRTEAVTIAMQKGILTIDN*" gene 588960..589601 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" downshifts 589595 /Source="Nicolas_upshifts" /id="D259" /incds=0 /nref=5 /ntot=147 /MaxReadThrough="1.15378" /MaxDrop="2.65603" /score="8.33575703" /energy="-6.4" /TU="NA" /idTUdmin="U419" /TUdmin="-176" /isTUend="FALSE" promotor_-10 complement(589628..589647) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(589649) /Source="Nicolas_upshifts" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(589661..589668) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 589709..589714 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 589717..591891 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941986; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative proton metabolite efflux transporter" /protein_id="NP_388424.1" /db_xref="EnsemblGenomes-Gn:BSU05430" /db_xref="EnsemblGenomes-Tr:CAB12350" /db_xref="GOA:P96687" /db_xref="InterPro:IPR000731" /db_xref="InterPro:IPR004869" /db_xref="SubtiList:BG12157" /db_xref="UniProtKB/Swiss-Prot:P96687" /translation="MSKMLYTLGGWVARNRIKAICAWIVVLVAAIGLAVTLKPSFSED MSIPDTPSEKAMDVIQKEFPHGPDKGSIRVIFGAGDGEKLTGKPAKKAIEDTFKEISK DDSVDSIASPFVTGTIAKDGTVAYADIQYKSSADDIKDYSIKHLKDSLKMADDEGLQT ELSGDVPGAEMEIGGVSEIVGIILAFVVLAITFGSLLIAGLPILTALIGLGVSIGLVL IGTQVFDIASVSLSLAGMIGLAVGIDYALFIFTKHRQFLGEGIQKNESIARAVGTAGS AVVFAGLTVIVALCGLTVVNIPFMSAMGLTAGLSVLMAVLASITLVPAVLSIAGKRMI PKSNKKIEKQSTETNVWGRFVTKNPIMLSVCSILILIVISIPSMHLELGLPDAGMKAK DNPDRRAYDLLAEGFGEGFNGQLTIVADATNATENKAEAFADAVKEIKGLDHVASVTP AMPNKEGNFAIITVVPETGPNDVTTKDLVHDVRSLSDKNGVDLLVTGSTAVNIDISDR LNDAIPVFAVLIVGFAFVLLTIVFRSLLVPLVAVAGFMLTMTATLGICVFVLQDGNLI DFFKIPEKGPILAFLPILSIGILFGLAMDYQVFLVSRMREEYVKTNNPVQAIQAGLKH SGPVVTAAGLIMIFVFAGFIFAGEASIKANGLALSFGVLFDAFIVRMTLIPSVMKLMG NAAWYLPKWLDKIIPNVDIEGHQLTKEIQPEIDHEQKKQISV*" gene 589717..591891 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" upshifts 589727 /Source="Nicolas_upshifts" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" promotor_-10 589729..589747 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(590793..590811) /Source="Nicolas_upshift_promotors" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(590793) /Source="Nicolas_upshifts" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(591895..592302) /Source="Nicolas_S_feature" /locus_tag="new_591895_592302_c" /HighExp="Paraq, H2O2, Oxctl, aero, LBGexp, dia15, GM 150, M/G, ferm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S187" promotor_-35 591912..591916 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 591926 /Source="Nicolas_upshifts" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 591929..591948 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(591940) /Source="Nicolas_upshifts" /id="D260" /incds=0 /nref=22 /ntot=134 /MaxReadThrough="-0.100210000000001" /MaxDrop="3.637" /score="4.29161871" /energy="-8.8" /TU="NA" /idTUdmin="U422" /TUdmin="-3" /isTUend="TRUE" CDS complement(592303..593205) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7765103, 22248594, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7765103, 22248594, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase NP" /protein_id="NP_388425.1" /db_xref="EnsemblGenomes-Gn:BSU05440" /db_xref="EnsemblGenomes-Tr:CAB12351" /db_xref="GOA:P96688" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:2R11" /db_xref="SubtiList:BG11957" /db_xref="UniProtKB/Swiss-Prot:P96688" /translation="MSNHSSSIPELSDNGIRYYQTYNESLSLWPVRCKSFYISTRFGQ THVIASGPEDAPPLVLLHGALFSSTMWYPNIADWSSKYRTYAVDIIGDKNKSIPENVS GTRTDYANWLLDVFDNLGIEKSHMIGLSLGGLHTMNFLLRMPERVKSAAILSPAETFL PFHHDFYKYALGLTASNGVETFLNWMMNDQNVLHPIFVKQFKAGVMWQDGSRNPNPNA DGFPYVFTDEELRSARVPILLLLGEHEVIYDPHSALHRASSFVPDIEAEVIKNAGHVL SMEQPTYVNERVMRFFNAETGISR*" gene complement(592303..593205) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" S_feature complement(593206..593301) /Source="Nicolas_S_feature" /locus_tag="new_593206_593301_c" /HighExp="nit, ferm, aero, LoTm, M/G, GM 150, Diami, Paraq, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S188" promotor_-10 complement(593281..593300) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(593301) /Source="Nicolas_upshifts" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" promotor_-35 complement(593314..593321) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(593407..594096) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10200972, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388426.1" /db_xref="EnsemblGenomes-Gn:BSU05450" /db_xref="EnsemblGenomes-Tr:CAB12352" /db_xref="GOA:P96689" /db_xref="InterPro:IPR007563" /db_xref="SubtiList:BG12158" /db_xref="UniProtKB/Swiss-Prot:P96689" /translation="MFGTIFNTVMIIAGSIIGGIFKKGIKDEYQDILMQAMGFAAVAL GINAITQHLPDSKYPILFIVSLAIGGLLGQIINLELRFNKLVNKFSKSNLAEGLSTAV LLFCIGSLSILGPVEAALHGDYTYLLTNGMLDGITSIVLASTFGFGIAAAALVLFSWQ GSIYLFAQVMESAINTDLINEITIVGGILILSSGLSILGIKKFKTLNLLPSLLIPPVV IFVIHAFGLRF*" gene complement(593407..594096) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" CDS complement(594186..594998) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of efflux transporter" /protein_id="NP_388427.1" /db_xref="EnsemblGenomes-Gn:BSU05460" /db_xref="EnsemblGenomes-Tr:CAB12353" /db_xref="GOA:P96690" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12159" /db_xref="UniProtKB/Swiss-Prot:P96690" /translation="MKEFFSIGEVSKLFNVKISALRYYDEIGLLKPEYKDEQTNYRYY STQQFERLDTIKYLRALGLPINKLLDFYNSQNTNTLLHLLKSQQVEIDRKKKELERIE RKISRRITHIEDAVNMPLHQISKIKLPAMRVAYLQHEYVLGHDIEHSLAELRTHLNVN EDIFIGKIGLSISAANVKAKQFDKYSSIFMILEDENEKTSSEIIFPSREYLQIRFKGS HPEAEPYYKKLLAYMKEHHYEVAGDSIEITLIDYGITNNLDNYVTEILLPIK*" gene complement(594186..594998) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" promotor_-10 complement(595027..595046) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(595040) /Source="Nicolas_upshifts" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" promotor_-35 complement(595062..595069) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(595109..596002) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="primary Mn(II) efflux pump" /protein_id="NP_388428.2" /db_xref="EnsemblGenomes-Gn:BSU05470" /db_xref="EnsemblGenomes-Tr:CAB12354" /db_xref="GOA:C0SP78" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12160" /db_xref="UniProtKB/Swiss-Prot:C0SP78" /translation="MASEREQISRKVALIALIANLILMAGKVFFGLVGDSEAVFADGI HSAADVVASIAVLAVIGISNKPPDQDHPFGHGKAEVISEAIVGIILVIVSVYILIEAI LSFVKGPSVPQYSALFAALISYVAKEILYRYSIKQGKKWNSKAIIAIAYDHKGDIVAS LAAFIGVLLAIIGNSRGWSYLLYADAIASAIVAYLIFKISMELIRPSVDVLMEKSVDP ELIEEYKAVIFQCDQVKRIDRIRAREHGHYKLLDVRLSLDHDLTIKQGHDIAREIRNE IKRQFSDVEEVLIHVNPYFEE*" gene complement(595109..596002) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" downshifts complement(595129) /Source="Nicolas_upshifts" /id="D261" /incds=0 /nref=23 /ntot=121 /MaxReadThrough="1.07979" /MaxDrop="4.0938" /score="12.079524" /energy="-6.2" /TU="NA" /idTUdmin="U424" /TUdmin="-2" /isTUend="TRUE" S_feature complement(596003..596095) /Source="Nicolas_S_feature" /locus_tag="new_596003_596095_c" /HighExp="LPh, HPh, LPhT, UNK1, MG t5, MG 5, MG 15, BMM, GM 120, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S189" promotor_-10 complement(596076..596095) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(596093) /Source="Nicolas_upshifts" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" promotor_-35 complement(596111..596118) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 596284..596291 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 596306..596325 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 596312 /Source="Nicolas_upshifts" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" CDS 596478..597098 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388429.1" /db_xref="EnsemblGenomes-Gn:BSU05480" /db_xref="EnsemblGenomes-Tr:CAB12355" /db_xref="GOA:P96692" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="PDB:3BEM" /db_xref="SubtiList:BG12161" /db_xref="UniProtKB/Swiss-Prot:P96692" /translation="MAEFTHLVNERRSASNFLSGHPITKEDLNEMFELVALAPSAFNL QHTKYVTVLDQDVKEKLKQAANGQYKVVSSSAVLLVLGDKQAYQQAADIYEGLKVLGI LNKQEYDHMVQDTVSFYENRGEQFKRDEAIRNASLSAMMFMLSAKEKGWDTCPMIGFD AEAVKRILNIDDQFEVVMMITIGKEKTESRRPRGYRKPVNEFVEYM*" gene 596478..597098 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" promotor_-35 596822..596828 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 596833 /Source="Nicolas_upshifts" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" promotor_-10 596842..596860 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 597114..598052 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" /EC_number="1.13.11.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dioxygenase" /protein_id="NP_388430.1" /db_xref="EnsemblGenomes-Gn:BSU05490" /db_xref="EnsemblGenomes-Tr:CAB12356" /db_xref="GOA:P96693" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:3OAJ" /db_xref="SubtiList:BG12162" /db_xref="UniProtKB/Swiss-Prot:P96693" /translation="MAKKTMGIHHITAIVGHPQENTDFYAGVLGLRLVKQTVNFDDPG TYHLYFGNEGGKPGTIITFFPWAGARQGVIGDGQVGVTSYVVPKGAMAFWEKRLEKFN VPYTKIERFGEQYVEFDDPHGLHLEIVEREEGEANTWTFGEVTPDVAIKGFGGATLLS EQPDKTADLLENIMGLERVGKEGDFVRYRSAGDIGNVIDLKLTPIGRGQMGAGTVHHI AWRANDDEDQLDWQRYIASHGYGVTPVRDRNYFNAIYFREHGEILFEIATDPPGFAHD ETQETMGEKLMLPVQYEPHRTQIEQGLLPFEVRELD*" gene 597114..598052 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" promotor_-35 598040..598043 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 598058..598077 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 598065..598153 /Source="Nicolas_S_feature" /locus_tag="new_598065_598153" /HighExp="Etha, BT, S6, S7, S8, G/S, GM 10, Gly, GM 15, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB, SigA" /TUshortPSig="0.658, 0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S190" upshifts 598065 /Source="Nicolas_upshifts" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" CDS 598154..598543 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15306018, 15849754, 16850406, 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound oxidoreductase" /protein_id="NP_388431.1" /db_xref="EnsemblGenomes-Gn:BSU05500" /db_xref="EnsemblGenomes-Tr:CAB12357" /db_xref="GOA:P96694" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12163" /db_xref="UniProtKB/Swiss-Prot:P96694" /translation="MEDAGLLLIRIMIGVVFLFYGTQKLFGWFGGYGIKGTGQWFESI GVKPGNVAAALSGLGELVSGILFILGVFLPLGAAIITIIMLGAIVKVHGAKGFANGAG GFEYNLVLIAVSIGVALIGSGAYALHF*" gene 598154..598543 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" downshifts 598534 /Source="Nicolas_upshifts" /id="D262" /incds=0 /nref=3 /ntot=91 /MaxReadThrough="1.0642" /MaxDrop="3.85597" /score="-8.69038499" /energy="-9.3" /TU="NA" /idTUdmin="U427" /TUdmin=29 /isTUend="FALSE" misc_feature 598657..598676 /Source="Nicolas_upshift_promotors" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 598659..598728 /Source="Nicolas_S_feature" /locus_tag="new_598659_598728" /HighExp="Diami, dia5, H2O2, dia15, Etha, S8, Paraq, Salt, LPhT, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S191" upshifts 598659 /Source="Nicolas_upshifts" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" CDS 598729..599067 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388432.1" /db_xref="EnsemblGenomes-Gn:BSU05510" /db_xref="EnsemblGenomes-Tr:CAB12358" /db_xref="GOA:P96695" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12164" /db_xref="UniProtKB/Swiss-Prot:P96695" /translation="MKEMTGLHSLVSIENFIKQHKFSFIYISRPGCTVCHAVLPQLRI VLDQFPNIKLGHINADDVAEVAGRFSVFTVPVLLLFIDGTEFLREARFVHFEQLEQKL KRVYRLYEGE*" gene 598729..599067 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" downshifts 599055 /Source="Nicolas_upshifts" /id="D263" /incds=0 /nref=9 /ntot=28 /MaxReadThrough="1.76745" /MaxDrop="4.78737" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=0 /isTUend="TRUE" CDS complement(599107..599343) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="NP_388433.1" /db_xref="EnsemblGenomes-Gn:BSU05520" /db_xref="EnsemblGenomes-Tr:CAB12359" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12810" /db_xref="UniProtKB/Swiss-Prot:O31496" /translation="MRSQINISNLTINGMTQNANTDIGQNLQNSHTANSKNYGVNFTL GDYSPSHSIIISASCDNDTSDQGQVDNPSSPSEE*" gene complement(599107..599343) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" downshifts complement(599131) /Source="Nicolas_upshifts" /id="D264" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.87679" /MaxDrop="2.5881" /score="9.38580075" /energy="-6" /TU="NA" /idTUdmin="U430" /TUdmin=418 /isTUend="FALSE" promotor_-35 599155..599161 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 599176..599187 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 599187 /Source="Nicolas_upshifts" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(599344..599505) /Source="Nicolas_S_feature" /locus_tag="new_599344_599505_c" /HighExp="BT, B36, S8, S7, G135, S5, S6, G180, Pyr, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S192" S_feature complement(599509..599874) /Source="Nicolas_S_feature" /locus_tag="new_599509_599874_c" /HighExp="BT, B36, S8, S7, S6, G/S, S5, Pyr, B60, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigGF, SigK" /TUshortPSig="0.994, 0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S193" downshifts complement(599549) /Source="Nicolas_upshifts" /id="D265" /incds=0 /nref=26 /ntot=52 /MaxReadThrough="2.64253" /MaxDrop="4.6761" /score="8.29803249" /energy="-12.4" /TU="NA" /idTUdmin="U430" /TUdmin=0 /isTUend="TRUE" CDS complement(599875..600105) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="YP_003097687.1" /db_xref="EnsemblGenomes-Gn:BSU05529" /db_xref="EnsemblGenomes-Tr:CAX52560" /db_xref="InterPro:IPR019618" /db_xref="UniProtKB/Swiss-Prot:C0H3W2" /translation="MMKFPVYIHSISGNSVFNNGFAVSISPFSVSKTTEGSGGSNTGL VFESNALSQTSSANQAQNVTYAIQELLSKLLA*" gene complement(599875..600105) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" downshifts 600089 /Source="Nicolas_upshifts" /id="D266" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.08051" /MaxDrop="3.36374" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=1034 /isTUend="FALSE" promotor_-10 complement(600126..600145) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(600143) /Source="Nicolas_upshifts" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" S_feature complement(600145..600228) /Source="Nicolas_S_feature" /locus_tag="new_600145_600228_c" /HighExp="S8, S5, S7, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK" /TUshortPSig="0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S194" promotor_-35 complement(600159..600168) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(600229..600906) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_388434.1" /db_xref="EnsemblGenomes-Gn:BSU05530" /db_xref="EnsemblGenomes-Tr:CAB12360" /db_xref="GOA:P96696" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12165" /db_xref="UniProtKB/Swiss-Prot:P96696" /translation="MNRLPFGYIKLRLAGRKANPMTNLIHHWSGGSMNFTWESLVLIV AGVILLRISGRKSIAQMTSTQTVVMISIGTIIVQPIIEYSLFKTLIAAAIFTSTLIVM EWIQMKSNTIEKMLTGKAKIVIENGQLHIENLKKMRLTADQLEMQLRLHGVTAIQDVK IATLEANGQLGIELTDDAKPLTVRDLKKLIHPDFINKDGQAQSGNQNIFDEVGKKNKK NVPKKLH*" gene complement(600229..600906) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" promotor_-10 complement(600877..600888) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(600891) /Source="Nicolas_upshifts" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" promotor_-35 complement(600903..600909) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(600907..601740) /Source="Nicolas_S_feature" /locus_tag="new_600907_601740_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, nit, B60" /AntisenseName="ydfS" /AntisenseCor="0.65823831974361602" /AntisenseRegPval="-34.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S195" promotor_-35 600922..600927 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 600942..600953 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 600947 /Source="Nicolas_upshifts" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" CDS 601019..601726 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388435.1" /db_xref="EnsemblGenomes-Gn:BSU05540" /db_xref="EnsemblGenomes-Tr:CAB12361" /db_xref="GOA:P96697" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12166" /db_xref="UniProtKB/Swiss-Prot:P96697" /translation="MIELEVVIRTVASFGLLLIAERILGKQTISQMTIFDFIAAITLG AIAAGLAYNTSIKPHNMAISFSIFVLTIFLISFLSIKNRKLRKFFAGDPTVLIQNGKI LESNMRKMRYTLDYLNQQLREKEIFNIEEVLFAILETNGQLTVLRKPQFRHVTKQDLM IAVNQEQRLPIELIMDGEIIENNLKQNRLTESWLLEELRKRDIKVKETVYAVLLGNGD IYVDQYKDHISVPMDKE*" gene 601019..601726 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" CDS complement(601741..602172) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11150673; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_388436.1" /db_xref="EnsemblGenomes-Gn:BSU05550" /db_xref="EnsemblGenomes-Tr:CAB12362" /db_xref="GOA:P96698" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG12167" /db_xref="UniProtKB/Swiss-Prot:P96698" /translation="MDFEKIRKWLEITNEYKQSDFWTNVLKYKAPEHFFDSEASTFVY DFYQDEEYNFIIVEMPGVYEEELTIRLLSKTQLLIKGTITPVFPAEMEVLRERYYGEI ERIIQLPEAAETHLLQIQLLNGLLHISYPRQVETVAFNKGL*" gene complement(601741..602172) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" CDS complement(602185..602427) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388437.1" /db_xref="EnsemblGenomes-Gn:BSU05560" /db_xref="EnsemblGenomes-Tr:CAB12363" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12168" /db_xref="UniProtKB/Swiss-Prot:P96699" /translation="MPYQINIANIKINGVTQNGNIDVGPTVHNSHTANSKYFGANFSL GDLSPTSSLLNTGNIDSDVSDQDQIGNPSAPISNQI*" gene complement(602185..602427) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" CDS complement(602441..602713) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388438.1" /db_xref="EnsemblGenomes-Gn:BSU05570" /db_xref="EnsemblGenomes-Tr:CAB12364" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12169" /db_xref="UniProtKB/Swiss-Prot:P96700" /translation="MPSTVINLYYLKINSISGNGSITIGEAAYNSPTNNQKSQGTNSS FGDTSPTESVMENFLNDPDVNDQTSIGNSDTSNVNAPPIAPPPILD*" gene complement(602441..602713) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" promotor_-10 complement(602735..602754) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(602739) /Source="Nicolas_upshifts" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" promotor_-35 complement(602768..602777) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 602932..602939 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 602955..602974 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 602963 /Source="Nicolas_upshifts" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" CDS 603012..603599 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388439.1" /db_xref="EnsemblGenomes-Gn:BSU05580" /db_xref="EnsemblGenomes-Tr:CAB12365" /db_xref="GOA:P96701" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12170" /db_xref="UniProtKB/Swiss-Prot:P96701" /translation="MKSKGVESRKRLLKAAANEFSVRGFHDAKVSEIVKKAGFTQPSF YLYFQSKEAIFAELITDFHSRVRKLTESLLLENGLNTEDVSKRVLLAVETVFQFLDED KDLTKIGFFLNPEAKQMKKDLAMVLKENLEAEQRLGYFHSELDMETVAECLVGMIEHL TESFLLTGIKDPASLAAEVVNLLIYGMLPKGNDVR*" gene 603012..603599 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" CDS 603596..603940 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388440.1" /db_xref="EnsemblGenomes-Gn:BSU05590" /db_xref="EnsemblGenomes-Tr:CAB12366" /db_xref="GOA:P96702" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12171" /db_xref="UniProtKB/Swiss-Prot:P96702" /translation="MISIMMKVSLAVFMLAGGIIKVSRVPFQVEHWRHYQYPLWFLTV TGILEIAGALAMTAGIWNRYAAIGAGVLFVVLMAGAIHAHMFRARQSVIMAIQAMICL IVSIMIIMGSYT*" gene 603596..603940 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" S_feature 603941..604102 /Source="Nicolas_S_feature" /locus_tag="new_603941_604102" /HighExp="Salt, Diami, dia15, dia5, aero, H2O2, SMMPr, Etha, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S196" CDS 604103..604576 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" /EC_number="2.3.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388441.1" /db_xref="EnsemblGenomes-Gn:BSU05600" /db_xref="EnsemblGenomes-Tr:CAB12367" /db_xref="GOA:P96703" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12172" /db_xref="UniProtKB/Swiss-Prot:P96703" /translation="MAFTLEDMTEEEFEAFRGMSVQNFAKQNITSGTWTEKEAFEKSE QAYENMIPNGRDSSNHYFWNITNDQGERMGWLWLYADPLHPQKEAFIYSFGLYEAFRG KGLAQLALQTLDERARELGAERLALHVFAHNETAVYLYQKMGYAMTNIRMRKQLC*" gene 604103..604576 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" S_feature 604577..605269 /Source="Nicolas_S_feature" /locus_tag="new_604577_605269" /HighExp="Salt, H2O2, dia15, aero, T-2.40H, Diami, T-3.40H, T-1.40H, T-4.40H, T-0.40H" /AntisenseName="vmlR" /AntisenseCor="-7.1224465259194999E-2" /AntisenseRegPval="-0.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S197" downshifts complement(604719) /Source="Nicolas_upshifts" /id="D267" /incds=0 /nref=4 /ntot=88 /MaxReadThrough="0.39199" /MaxDrop="3.39645" /score="18.2783449" /energy="-8.8" /TU="NA" /idTUdmin="U436" /TUdmin=0 /isTUend="TRUE" CDS complement(604736..606379) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16109936, 22226636, 24687494, 25891423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16109936, 22226636, 24687494, 25891423; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding cassette efflux transporter" /protein_id="NP_388442.1" /db_xref="EnsemblGenomes-Gn:BSU05610" /db_xref="EnsemblGenomes-Tr:CAB12368" /db_xref="GOA:P39115" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG10767" /db_xref="UniProtKB/Swiss-Prot:P39115" /translation="MKEIVTLTNVSYEVKDQTVFKHVNASVQQGDIIGIIGKNGAGKS TLLHLIHNDLAPAQGQILRKDIKLALVEQETAAYSFADQTPAEKKLLEKWHVPLRDFH QLSGGEKLKARLAKGLSEDADLLLLDEPTNHLDEKSLQFLIQQLKHYNGTVILVSHDR YFLDEAATKIWSLEDQTLIEFKGNYSGYMKFREKKRLTQQREYEKQQKMVERIEAQMN GLASWSEKAHAQSTKKEGFKEYHRVKAKRTDAQIKSKQKRLEKELEKAKAEPVTPEYT VRFSIDTTHKTGKRFLEVQNVTKAFGERTLFKNANFTIQHGEKVAIIGPNGSGKTTLL NIILGQETAEGSVWVSPSANIGYLTQEVFDLPLEQTPEELFENETFKARGHVQNLMRH LGFTAAQWTEPIKHMSMGERVKIKLMAYILEEKDVLILDEPTNHLDLPSREQLEETLS QYSGTLLAVSHDRYFLEKTTNSKLVISNNGIEKQLNDVPSERNEREELRLKLETERQE VLGKLSFMTPNDKGYKELDQAFNELTKRIKELDHQDKKD*" gene complement(604736..606379) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" S_feature complement(606414..606611) /Source="Nicolas_S_feature" /locus_tag="new_606414_606611_c" /HighExp="BC, Sw, B60, B36, LoTm, S7, HiOs, S4, BI, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S198" promotor_-35 606428..606430 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 606447..606465 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 606451 /Source="Nicolas_upshifts" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts complement(606457) /Source="Nicolas_upshifts" /id="D268" /incds=0 /nref=210 /ntot=265 /MaxReadThrough="3.59768" /MaxDrop="6.27457" /score="29.5863709" /energy="-11.8" /TU="U436" /idTUdmin="U437" /TUdmin=242 /isTUend="FALSE" downshifts 606577 /Source="Nicolas_upshifts" /id="D269" /incds=0 /nref=35 /ntot=150 /MaxReadThrough="1.71902" /MaxDrop="4.95368" /score="-7.23582918" /energy="-13.3" /TU="NA" /idTUdmin="U435" /TUdmin="-2" /isTUend="TRUE" promotor_-10 complement(606603..606622) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(606615) /Source="Nicolas_upshifts" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" promotor_-35 complement(606635..606642) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(606698) /Source="Nicolas_upshifts" /id="D270" /incds=0 /nref=92 /ntot=203 /MaxReadThrough="2.22553" /MaxDrop="5.71399" /score="18.9878298" /energy="-13.3" /TU="NA" /idTUdmin="U437" /TUdmin=1 /isTUend="TRUE" CDS complement(606699..608075) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16109936, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388443.1" /db_xref="EnsemblGenomes-Gn:BSU05620" /db_xref="EnsemblGenomes-Tr:CAB12369" /db_xref="GOA:P96704" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12173" /db_xref="UniProtKB/Swiss-Prot:P96704" /translation="MTDDMTKDNINQQTLQRGLKNRHIQLIAIGGAIGTGLFLGSGKS IHFAGPSILFAYMITGIICFLIMRSLGELLLSNLNYHSFVDFVQDYLGDMAAFITGWT YWFCWISIAMADLTAVGLYTQYWLPGVPQWVPGLIALIILLIMNLATVKLFGELEFWF ALIKVIAILALIVIGLVMIFKGFSTSSGVSSFTNLWSHGGLFPNGMHGFILSFQMVVF AFVGIELVGLTAGETENPEKVIPKAINNIPVRVLLFYIGALLVIMSIYPWDIINPSES PFVQVFVAVGIVGAASIINFVVLTSAASACNSAVFSTSRMVYSLAKDHNAPESMAKLT QRKVPRNALFFSAIVILIGVTLNYIMPEGVFTLITSISTVCFIYIWGITVICHMKYRK TRPELAKTNKFKLPLYPFTNYLILAFLAFVLVVLALAQDTRVSLFVTPVWFILLIVIY KVRKAKHQ*" gene complement(606699..608075) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" misc_feature complement(608125..608144) /Source="Nicolas_upshift_promotors" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(608140) /Source="Nicolas_upshifts" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" CDS complement(608246..608764) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1847907, 3110138, 12644484, 16267290, 22059487; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nuclease inhibitor" /protein_id="NP_388444.1" /db_xref="EnsemblGenomes-Gn:BSU05630" /db_xref="EnsemblGenomes-Tr:CAB12370" /db_xref="GOA:Q02886" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG10539" /db_xref="UniProtKB/Swiss-Prot:Q02886" /translation="MSDFAFKLYEYNVWANQQIFNRLKELPKEIYHQEIQSVFPSISH VLSHVYLSDLGWIEVFSGKTLSDALALAEQLKEQTEAKEIEEMEDLFLRLSERYILFL QQKEQLNKPLQIQNPSSGIMKTTVSELLPHVVNHGTYHRGNITAMLRQAGYASAPTDY GLYLFMTKTEKA*" gene complement(608246..608764) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" downshifts complement(608260) /Source="Nicolas_upshifts" /id="D271" /incds=0 /nref=35 /ntot=176 /MaxReadThrough="2.77148" /MaxDrop="6.32316" /score="16.2748201" /energy="-15" /TU="NA" /idTUdmin="U438" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(608790..608809) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(608809) /Source="Nicolas_upshifts" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" promotor_-35 complement(608825..608828) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 608846..608853 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 608868..608887 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 608886 /Source="Nicolas_upshifts" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" CDS 608933..609391 /gene="ydgG" /locus_tag="BSU_05640" /old_locus_tag="BSU05640" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_388445.1" /db_xref="EnsemblGenomes-Gn:BSU05640" /db_xref="EnsemblGenomes-Tr:CAB12371" /db_xref="GOA:P96705" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12174" /db_xref="UniProtKB/Swiss-Prot:P96705" /translation="MNEQKLCQAINLFVEVLLEGTEFVHREINQDVFKHISREQADLL KILKVKGPTSPGSLAMYQNVHKSAISNRLKKLLEKGLVQWDDCPEKSDRRSKLINITP SGEHILEELDSAIFNALKPLIDDIDEEHLHSIIEIFTILKSKFKGGDSAE*" gene 608933..609391 /gene="ydgG" /locus_tag="BSU_05640" /old_locus_tag="BSU05640" CDS 609388..612045 /gene="ydgH" /locus_tag="BSU_05650" /old_locus_tag="BSU05650" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941986; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_388446.1" /db_xref="EnsemblGenomes-Gn:BSU05650" /db_xref="EnsemblGenomes-Tr:CAB12372" /db_xref="GOA:P96706" /db_xref="InterPro:IPR000731" /db_xref="InterPro:IPR004869" /db_xref="SubtiList:BG12175" /db_xref="UniProtKB/Swiss-Prot:P96706" /translation="MRAIIKFKWAIAAIVLALTVVLSLFSPNLTELANQKGQAQLPAD AVSERANAILKQAGEDNNSISVVFTLDNAIKKETENQLRIIIDKIKKIDGVEEVTSPL SAEKEVKDQLMSKDKKTVLMPVTITGSDKKAEKIADEIYQIVPDDLTAYITGASLINQ DFAHSSEEGLKKTEVITVCLIIGLLLIVFRSVVTPFIPIVVVGFSYLISQSILGILVY NVDFPISTFTQTFLVAILFGIGTDYCILLLTRFREELANGHDKKEAALIAYRTGGKTL FISGFAVLIGFSALGFAKFAIFQSAVGVAVGVGILMIILYTLLPLFMVTLGEKLFWPS KKVLSHSDNKLWAFLGRHSVARPFLFIVITVVITLPFILTYDDQISFDSTAEISSDYK SIKALEAIKDGFGEGKAFPINVVVKGDKDLTTADTIPYLGNISKAIEKVDHVDSVMTI TQPTGKKIKDLYIDNQLGSVSDGLDKTVKGIADVQSGLTDIENGLNQMAGQTGSASNG GSGGSLGDAADGLGKINQQLQLVSKQISQTGNTAQTVQQLTAISGQLGQIQTGLEQAN QQLSGQQAQAGTLTESLKKLSEGVKSANEGLTKVSDGITASSDILEDMSKSPTVRDTG IFIPDQVMKDKDFKKSIDQYSFADGKGVQLSVVLDSNPYSEQAITTINQIKKAVANEV DGTPLENAQIVYGGVTSMNADLKELSTTDFSRTMVIMIIGLFIVLTILFRSMIMPIYM IASLLLTYYTSISITELIFVNGLGNAGVSWAVPFFSFVILIALGVDYSIFLLDRFKEE VHLGIEQGVVRSMSKMGSVIITAAIILAGTFAAMMPSGVNTLMQVASVIIIGLLLYGL VILPLFIPAIIATFGEGNWWPFGRKKGKE*" gene 609388..612045 /gene="ydgH" /locus_tag="BSU_05650" /old_locus_tag="BSU05650" downshifts 612166 /Source="Nicolas_upshifts" /id="D272" /incds=0 /nref=3 /ntot=27 /MaxReadThrough="0.245049999999999" /MaxDrop="4.45167" /score="13.780898" /energy="-13.9" /TU="NA" /idTUdmin="U439" /TUdmin=22 /isTUend="TRUE" CDS complement(612191..612820) /gene="ydgI" /locus_tag="BSU_05660" /old_locus_tag="BSU05660" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26415543; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nitroreductase of unidentified specificity (reduces 5-(aziridin-1-yl)-2,4-dinitrobenzamide prodrug)" /protein_id="NP_388447.1" /db_xref="EnsemblGenomes-Gn:BSU05660" /db_xref="EnsemblGenomes-Tr:CAB12385" /db_xref="GOA:P96707" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG12176" /db_xref="UniProtKB/Swiss-Prot:P96707" /translation="MIKTNDFMEIMKGRRSIRNYDPAVKISKEEMTEILEEATTAPSS VNAQPWRFLVIDSPEGKEKLAPLASFNQTQVTTSSAVIAVFADMNNADYLEEIYSKAV ELGYMPQEVKDRQIAALTAHFEKLPAQVNRETILIDGGLVSMQLMLTARAHGYDTNPI GGYDKENIAETFGLDKERYVPVMLLSIGKAADEGYASYRLPIDTIAEWK*" gene complement(612191..612820) /gene="ydgI" /locus_tag="BSU_05660" /old_locus_tag="BSU05660" downshifts complement(612195) /Source="Nicolas_upshifts" /id="D273" /incds=0 /nref=21 /ntot=184 /MaxReadThrough="2.66406" /MaxDrop="6.06581" /score="21.7451043" /energy="-16.6" /TU="NA" /idTUdmin="U440" /TUdmin=3 /isTUend="TRUE" CDS complement(612836..613330) /gene="ydgJ" /locus_tag="BSU_05670" /old_locus_tag="BSU05670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_388448.1" /db_xref="EnsemblGenomes-Gn:BSU05670" /db_xref="EnsemblGenomes-Tr:CAB12386" /db_xref="GOA:P96708" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12177" /db_xref="UniProtKB/Swiss-Prot:P96708" /translation="MTCQSLIYQLIVLTGKKGWVLASFCSEEAEILYQLQGVNKVIGV KFEACTGISQSRLELLTLLYHADEISQSDLQKKVNIDSAAVTRHLKQLESKGMVSRRR KPEDNRITLVRLTDQGRERIESSKKEKERFMKEMLANVSAEERRLLIDVLARMRNNIN NIEA*" gene complement(612836..613330) /gene="ydgJ" /locus_tag="BSU_05670" /old_locus_tag="BSU05670" promotor_-10 complement(613322..613341) /Source="Nicolas_upshift_promotors" /id="U440" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1967 /SigmaFactorBS="ttatgcgctgggaggttgttcaaaagtgcaaatggCTTGCAa gatgaaatcaatcgTTGTATATTAATTGACGTGTcaatcattgatatatcaattaata g" /listShort="ydgJ, ydgI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(613337) /Source="Nicolas_upshifts" /id="U440" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1967 /SigmaFactorBS="ttatgcgctgggaggttgttcaaaagtgcaaatggCTTGCAa gatgaaatcaatcgTTGTATATTAATTGACGTGTcaatcattgatatatcaattaata g" /listShort="ydgJ, ydgI" /GFF_Attribute="listLong" promotor_-35 complement(613357..613362) /Source="Nicolas_upshift_promotors" /id="U440" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1967 /SigmaFactorBS="ttatgcgctgggaggttgttcaaaagtgcaaatggCTTGCAa gatgaaatcaatcgTTGTATATTAATTGACGTGTcaatcattgatatatcaattaata g" /listShort="ydgJ, ydgI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 613528..613530 /Source="Nicolas_upshift_promotors" /id="U441" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=2606 /SigmaFactorBS="ttcggaatatcactttgccggcccgtgctcaagcggCTTtca caggctgaaagtTATGATACAATATACAAATGtttcacagcttcaatccatagttgga g" /listShort="S199, ydgK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 613546..613565 /Source="Nicolas_upshift_promotors" /id="U441" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=2606 /SigmaFactorBS="ttcggaatatcactttgccggcccgtgctcaagcggCTTtca caggctgaaagtTATGATACAATATACAAATGtttcacagcttcaatccatagttgga g" /listShort="S199, ydgK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 613552..613640 /Source="Nicolas_S_feature" /locus_tag="new_613552_613640" /HighExp="H2O2, G180, G135, Diami, Paraq, Oxctl, G150, LBGexp, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S199" upshifts 613552 /Source="Nicolas_upshifts" /id="U441" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=2606 /SigmaFactorBS="ttcggaatatcactttgccggcccgtgctcaagcggCTTtca caggctgaaagtTATGATACAATATACAAATGtttcacagcttcaatccatagttgga g" /listShort="S199, ydgK" /GFF_Attribute="listLong" CDS 613641..614849 /gene="ydgK" /locus_tag="BSU_05680" /old_locus_tag="BSU05680" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388449.1" /db_xref="EnsemblGenomes-Gn:BSU05680" /db_xref="EnsemblGenomes-Tr:CAB12387" /db_xref="GOA:P96709" /db_xref="InterPro:IPR004812" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12178" /db_xref="UniProtKB/Swiss-Prot:P96709" /translation="MLHNPTGKERLALAFLLGMLAILGPLNIDMYLPSFPEIAKDLSA SASLVQLSLTACLVGLTIGQLIVGPVSDAQGRRKPLLICIFLFALSSLFCALSPNITT LVAARFLQGFTASAGLVLSRAIVRDVFTGRELSKFFSLLMVITAVAPMVAPMTGGAIL LLPFATWHTIFHVLMIIGFLLVLLIALRLKETLPLEKRIPSSIGTSVKTMGSLLKDRS FMGYALTVGFIHGGSFAYVSGTPFVYQDIYGVSPQVFSILFGINGLAIISGSFIIGRF GGIIHEKSLLRIAVITAMIATAVLLTMTMIHGPLATLVISIFIYMITIGMVLTSTFTL AMEKQGHRAGSASALLGMLPLLLGSIVSPLVGINETTAVPMGAIMFVTAVIGSLAFFG LTKERVGQNS*" gene 613641..614849 /gene="ydgK" /locus_tag="BSU_05680" /old_locus_tag="BSU05680" downshifts 614828 /Source="Nicolas_upshifts" /id="D274" /incds=0 /nref=23 /ntot=112 /MaxReadThrough="0.507390000000001" /MaxDrop="3.27202" /score="25.806679" /energy="-7.5" /TU="NA" /idTUdmin="U441" /TUdmin=0 /isTUend="TRUE" CDS complement(614885..615622) /gene="ydhB" /locus_tag="BSU_05690" /old_locus_tag="BSU05690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388450.2" /db_xref="EnsemblGenomes-Gn:BSU05690" /db_xref="EnsemblGenomes-Tr:CAB12388" /db_xref="GOA:O05493" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG12179" /db_xref="UniProtKB/Swiss-Prot:O05493" /translation="MLIILVMFLLGIILGFIGAGGAGFVIALLTLLFHIPIHTALGTS LAGMAFTSLSGAYSHYREGNIQMKIGLIVGGFAAVGSFFGAKLTSFIPADLLHYLTAG MLFLSAILILIRLFILKEKAQVNQSTLSTYTRAVILGIAAGVLSGTFGIGSAPFIQIG LMIMLNLSIRHSVGTTMLVIIPLAVGGGIGYITEGFVDYVLLVKVLVGTMCGAYVGAK FTNLMPKVVLKSAIFLTPAIAGLLLLF*" gene complement(614885..615622) /gene="ydhB" /locus_tag="BSU_05690" /old_locus_tag="BSU05690" S_feature complement(615623..615761) /Source="Nicolas_S_feature" /locus_tag="new_615623_615761_c" /HighExp="T0.30H, T1.30H, T1.0H, T-0.40H, T2.0H, T0.0H, LBGstat, T2.30H, T-1.10H, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.108111" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S200" promotor_-10 complement(615749..615768) /Source="Nicolas_upshift_promotors" /id="U442" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.773226773226773" /psig="0.999000999001" /xcortree=1711 /SigmaFactorBS="atataacagatggtaatgggaagcaacaaactGCCTTGTCag atccctgaattTGAGGTACGATATGTTTGCTgaacgacggtcgacggactactggcaa c" /listShort="S200, ydhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(615761) /Source="Nicolas_upshifts" /id="U442" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.773226773226773" /psig="0.999000999001" /xcortree=1711 /SigmaFactorBS="atataacagatggtaatgggaagcaacaaactGCCTTGTCag atccctgaattTGAGGTACGATATGTTTGCTgaacgacggtcgacggactactggcaa c" /listShort="S200, ydhB" /GFF_Attribute="listLong" promotor_-35 complement(615782..615789) /Source="Nicolas_upshift_promotors" /id="U442" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.773226773226773" /psig="0.999000999001" /xcortree=1711 /SigmaFactorBS="atataacagatggtaatgggaagcaacaaactGCCTTGTCag atccctgaattTGAGGTACGATATGTTTGCTgaacgacggtcgacggactactggcaa c" /listShort="S200, ydhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 615793..615800 /Source="Nicolas_upshift_promotors" /id="U443" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.999000999001" /xcortree=1978 /SigmaFactorBS="atcgtacctcaaattcagggatctgacaaggcagtTTGTTGC TtcccattaccatcTGTTATATGATTTTGATGAAgaaaagcccttgaatatattcaaa a" /listShort="ydhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 615814..615833 /Source="Nicolas_upshift_promotors" /id="U443" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.999000999001" /xcortree=1978 /SigmaFactorBS="atcgtacctcaaattcagggatctgacaaggcagtTTGTTGC TtcccattaccatcTGTTATATGATTTTGATGAAgaaaagcccttgaatatattcaaa a" /listShort="ydhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 615818 /Source="Nicolas_upshifts" /id="U443" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.999000999001" /xcortree=1978 /SigmaFactorBS="atcgtacctcaaattcagggatctgacaaggcagtTTGTTGC TtcccattaccatcTGTTATATGATTTTGATGAAgaaaagcccttgaatatattcaaa a" /listShort="ydhC" /GFF_Attribute="listLong" CDS 615871..616545 /gene="ydhC" /locus_tag="BSU_05700" /old_locus_tag="BSU05700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_388451.1" /db_xref="EnsemblGenomes-Gn:BSU05700" /db_xref="EnsemblGenomes-Tr:CAB12389" /db_xref="GOA:O05494" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12180" /db_xref="UniProtKB/Swiss-Prot:O05494" /translation="MDDFKLDKPTPYYLQFYNQLKKMIFNGTFKPGERINETQLAKSF GVSRSPIREAMRLLEKDGLLKADDRNGFSITSLTAKDVDEIYKIRIPLEQLAVELVID EADEEELTILEKQLEETEKAIHNGTEDTEIIRLNQKFHELLVDFSHNRHLKNLLEHVN DLIHFCRILNYTGDHRAETILREHRRIFEEVKKKNKEAAKQHVLAHFNHDCEHLKHVL EEGKEN*" gene 615871..616545 /gene="ydhC" /locus_tag="BSU_05700" /old_locus_tag="BSU05700" promotor_-35 616604..616609 /Source="Nicolas_upshift_promotors" /id="U444" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1131 /SigmaFactorBS="agcagaacccttggtatttttttatgtattcacCACATAtct aagaggccccgtTAATAAGATTTTATGATGGtttgactaacgaataatgggggttaaa t" /listShort="ydhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 616625..616643 /Source="Nicolas_upshift_promotors" /id="U444" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1131 /SigmaFactorBS="agcagaacccttggtatttttttatgtattcacCACATAtct aagaggccccgtTAATAAGATTTTATGATGGtttgactaacgaataatgggggttaaa t" /listShort="ydhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 616631 /Source="Nicolas_upshifts" /id="U444" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1131 /SigmaFactorBS="agcagaacccttggtatttttttatgtattcacCACATAtct aagaggccccgtTAATAAGATTTTATGATGGtttgactaacgaataatgggggttaaa t" /listShort="ydhD" /GFF_Attribute="listLong" CDS 616672..617934 /gene="spoL" /locus_tag="BSU_05710" /old_locus_tag="BSU05710" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11011148, 12177332; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore cortex lytic enzyme" /protein_id="NP_388452.2" /db_xref="EnsemblGenomes-Gn:BSU05710" /db_xref="EnsemblGenomes-Tr:CAB12390" /db_xref="GOA:O05495" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="PDB:3CZ8" /db_xref="SubtiList:BG12181" /db_xref="UniProtKB/Swiss-Prot:O05495" /translation="MFIHIVGPGDSLFSIGRRYGASVDQIRGVNGLDETNIVPGQALL IPLYVYTVQPRDTLTAIAAKAFVPLERLRAANPGISPNALQAGAKITIPSISNYIAGT LSFYVLRNPDLDRELINDYAPYSSSISIFEYHIAPNGDIANQLNDAAAIETTWQRRVT PLATITNLTSGGFSTEIVHQVLNNPTARTNLVNNIYDLVSTRGYGGVTIDFEQVSAAD RDLFTGFLRQLRDRLQAGGYVLTIAVPAKTSDNIPWLRGYDYGGIGAVVNYMFIMAYD WHHAGSEPGPVAPITEIRRTIEFTIAQVPSRKIIIGVPLYGYDWIIPYQPGTVASAIS NQNAIERAMRYQAPIQYSAEYQSPFFRYSDQQGRTHEVWFEDVRSMSRKMQIVREYRL QAIGAWQLTLGFTPGPWLLRKFFTIRKV*" gene 616672..617934 /gene="spoL" /locus_tag="BSU_05710" /old_locus_tag="BSU05710" downshifts 617908 /Source="Nicolas_upshifts" /id="D275" /incds=0 /nref=33 /ntot=81 /MaxReadThrough="2.3134" /MaxDrop="5.20337" /score="15.7593331" /energy="-7.1" /TU="NA" /idTUdmin="U444" /TUdmin=0 /isTUend="TRUE" promotor_-35 618006..618013 /Source="Nicolas_upshift_promotors" /id="U445" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.999000999001" /xcortree=1616 /SigmaFactorBS="taagtccagagcagcagaatagttcattcatttgtACCTTGC AtgggttgtgttccCATTTTACGATTAGTAGTAGtctgatcaaacaaagagtcagaat a" /listShort="ydhE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 618027..618046 /Source="Nicolas_upshift_promotors" /id="U445" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.999000999001" /xcortree=1616 /SigmaFactorBS="taagtccagagcagcagaatagttcattcatttgtACCTTGC AtgggttgtgttccCATTTTACGATTAGTAGTAGtctgatcaaacaaagagtcagaat a" /listShort="ydhE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 618031 /Source="Nicolas_upshifts" /id="U445" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.999000999001" /xcortree=1616 /SigmaFactorBS="taagtccagagcagcagaatagttcattcatttgtACCTTGC AtgggttgtgttccCATTTTACGATTAGTAGTAGtctgatcaaacaaagagtcagaat a" /listShort="ydhE" /GFF_Attribute="listLong" CDS 618095..619282 /gene="ydhE" /locus_tag="BSU_05720" /old_locus_tag="BSU05720" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20639339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_388453.2" /db_xref="EnsemblGenomes-Gn:BSU05720" /db_xref="EnsemblGenomes-Tr:CAB12391" /db_xref="GOA:O05496" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="SubtiList:BG12182" /db_xref="UniProtKB/Swiss-Prot:O05496" /translation="MKTVLILNFPAEGHVNPTLGITKAFSDKGYDVHYISTEKYKKRL EAAGATVHLHRDLLRTTPIHVGSPNGILDFVKIHIKTSLDILQIVKDLSKSIQFDFVY YDKFGAGELVRDYLDIPGVSSSASFLFGEEHLKILPLHPESGAPLELDQECEDLLAKM KETYGVAPKNLVQFMNNKGELNVVYTSRYFQPESDRFGDECLFIGPSFPKRAEKTDFP IEQLKDEKVIYISMGTVLDHTEDFFNLCIDAFSGFNGKVVIAAGEKADLTKLKQAPEN FIIAPYVPQLEVLEQSDVFITHGGMNSVNEGIHFSVPLVVMPHDKDQPMVAQRLSELH AGYVISKDEVNAQILKQAVDEVLRNDQYTAGIKKINQSFKECMDMEEVMERIDELIRQ KNK*" gene 618095..619282 /gene="ydhE" /locus_tag="BSU_05720" /old_locus_tag="BSU05720" downshifts 619294 /Source="Nicolas_upshifts" /id="D276" /incds=0 /nref=17 /ntot=224 /MaxReadThrough="1.77672" /MaxDrop="5.25325" /score="-6.36206618" /energy="-12.6" /TU="NA" /idTUdmin="U445" /TUdmin=1 /isTUend="TRUE" CDS complement(619321..620031) /gene="ydhF" /locus_tag="BSU_05730" /old_locus_tag="BSU05730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913081, 11557812; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative phosphate-starvation lipoprotein" /protein_id="NP_388454.1" /db_xref="EnsemblGenomes-Gn:BSU05730" /db_xref="EnsemblGenomes-Tr:CAB12392" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="SubtiList:BG12183" /db_xref="UniProtKB/Swiss-Prot:O05497" /translation="MRRILSILVFAIMLAGCSSNASTEKQHAGGEKTVKAEPQSTSSQ KDSTDDYQPNSQVTDDRTLHKVGQTFSDDKGKAVLKDIKQVNKTYKIGDVELTVKEMK LIHLRPDYSMIDYFHELTHDEEFDFVKVFVDIKNTSTKKVNVAPIALMKTNTGETFDW NKDIYLEELNGELEGGAEKSGNLGFIVNASSGHAHDKAADAEKKTKEIKWIEITTSDV FDHNHKKISDAQKIKIKF*" gene complement(619321..620031) /gene="ydhF" /locus_tag="BSU_05730" /old_locus_tag="BSU05730" downshifts complement(619347) /Source="Nicolas_upshifts" /id="D277" /incds=0 /nref=11 /ntot=36 /MaxReadThrough="4.05808" /MaxDrop="4.7318" /score="13.7192471" /energy="-12.6" /TU="NA" /idTUdmin="U446" /TUdmin=0 /isTUend="TRUE" CDS complement(620097..621485) /gene="phoB" /locus_tag="BSU_05740" /old_locus_tag="BSU05740" /EC_number="3.1.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9335276, 10913081, 16030210, 16491025, 26382712, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9335276, 10913081, 16030210, 16491025, 26382712, 27226549; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alkaline phosphatase III (promiscuous, heptaprenylglyceryl phosphate is a substrate)" /protein_id="NP_388455.2" /db_xref="EnsemblGenomes-Gn:BSU05740" /db_xref="EnsemblGenomes-Tr:CAB12393" /db_xref="GOA:P19405" /db_xref="InterPro:IPR001952" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR018299" /db_xref="SubtiList:BG10697" /db_xref="UniProtKB/Swiss-Prot:P19405" /translation="MKKFPKKLLPIAVLSSIAFSSLASGSVPEASAQEKKKGNQDEIK NVIVLIGDGMGVSYTSAYRYLKDNKKTKVVEPTAFDQYLVGQQTTYPDDPEQNVTDSA AAATAMSAGIKTYNNAIAVDNDGSEAKTVLEAAKEKGKATGLVATSEITHATPASFGS HDHSRKNMNSIADDYFDEMVNGKHKIDVLLGGGKSNFDRKDRNLIKEFKKAGYSYVDD RKDMLKNKDSQVLGLFADGGLPKKIDRTKDIPSLKDMTNTAIKKLNKDKDGFFLMVEG SQIDWAGHDNDIVGAMSEMEDFEQAYKAAIDFAKKDKHTLVVATADHSTGGYSIGADG IYNWFSEPIKAAKRTPDFMAEKIADGADVEKTLKTYIDQKKLALTKAEIQSVEEAAKS KEVLDIDNAIENIFNKRSHTGWTTGGHTGEDVPVYAYGPSSETFAGQIDNTEIAKNVF KALQYNIKINDK*" gene complement(620097..621485) /gene="phoB" /locus_tag="BSU_05740" /old_locus_tag="BSU05740" promotor_-10 complement(621542..621559) /Source="Nicolas_upshift_promotors" /id="U446" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.982017982017982" /psig="0.011988011988012" /xcortree=9 /SigmaFactorBS="ggtgccagttcattattcttgtaaatccaaTCTTTAAAatcg atTAATACTAGCTTAACAGTttaaaaatataattgggttgtcattgagattcatctat a" /listShort="phoB, ydhF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(621543) /Source="Nicolas_upshifts" /id="U446" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.982017982017982" /psig="0.011988011988012" /xcortree=9 /SigmaFactorBS="ggtgccagttcattattcttgtaaatccaaTCTTTAAAatcg atTAATACTAGCTTAACAGTttaaaaatataattgggttgtcattgagattcatctat a" /listShort="phoB, ydhF" /GFF_Attribute="listLong" S_feature complement(621545..621613) /Source="Nicolas_S_feature" /locus_tag="new_621545_621613_c" /HighExp="S6, S4, S5, S3, S7, LoTm, S8, T5.0H, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S201" promotor_-35 complement(621566..621573) /Source="Nicolas_upshift_promotors" /id="U446" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.982017982017982" /psig="0.011988011988012" /xcortree=9 /SigmaFactorBS="ggtgccagttcattattcttgtaaatccaaTCTTTAAAatcg atTAATACTAGCTTAACAGTttaaaaatataattgggttgtcattgagattcatctat a" /listShort="phoB, ydhF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(621603..621621) /Source="Nicolas_upshift_promotors" /id="U447" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1157 /SigmaFactorBS="tattcctccaatttatttctttagtactatcgctctttcCTT CTAaaacttctcataaaaGAATAACCATTATTTAAGGgtgccagttcattattcttgt a" /listShort="S201, phoB, ydhF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(621621) /Source="Nicolas_upshifts" /id="U447" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1157 /SigmaFactorBS="tattcctccaatttatttctttagtactatcgctctttcCTT CTAaaacttctcataaaaGAATAACCATTATTTAAGGgtgccagttcattattcttgt a" /listShort="S201, phoB, ydhF" /GFF_Attribute="listLong" promotor_-35 complement(621637..621642) /Source="Nicolas_upshift_promotors" /id="U447" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1157 /SigmaFactorBS="tattcctccaatttatttctttagtactatcgctctttcCTT CTAaaacttctcataaaaGAATAACCATTATTTAAGGgtgccagttcattattcttgt a" /listShort="S201, phoB, ydhF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 621690..621697 /Source="Nicolas_upshift_promotors" /id="U448" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.642357642357642" /psig="0.997002997002997" /xcortree=1887 /SigmaFactorBS="tagtactaaagaaataaattggaggaatagatactggCCGTG GATaggcggactgaaaTCTGCTATAGTCGCATAGAAgcaacccgcttacatcttgaac a" /listShort="S202, ydhG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 621711..621730 /Source="Nicolas_upshift_promotors" /id="U448" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.642357642357642" /psig="0.997002997002997" /xcortree=1887 /SigmaFactorBS="tagtactaaagaaataaattggaggaatagatactggCCGTG GATaggcggactgaaaTCTGCTATAGTCGCATAGAAgcaacccgcttacatcttgaac a" /listShort="S202, ydhG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 621713..621846 /Source="Nicolas_S_feature" /locus_tag="new_621713_621846" /HighExp="Diami, dia15, H2O2, Paraq, Oxctl, HPh, G180, G135, LPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S202" upshifts 621713 /Source="Nicolas_upshifts" /id="U448" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.642357642357642" /psig="0.997002997002997" /xcortree=1887 /SigmaFactorBS="tagtactaaagaaataaattggaggaatagatactggCCGTG GATaggcggactgaaaTCTGCTATAGTCGCATAGAAgcaacccgcttacatcttgaac a" /listShort="S202, ydhG" /GFF_Attribute="listLong" CDS 621847..622218 /gene="fra" /locus_tag="BSU_05750" /old_locus_tag="BSU05750" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:20087498, 21744456, 25826316" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20087498, 21744456, 25826316; Product type f: factor" /codon_start=1 /transl_table=11 /product="frataxin; iron/sulfur chaperone" /protein_id="NP_388456.1" /db_xref="EnsemblGenomes-Gn:BSU05750" /db_xref="EnsemblGenomes-Tr:CAB12394" /db_xref="GOA:Q797E6" /db_xref="InterPro:IPR014922" /db_xref="PDB:2OC6" /db_xref="SubtiList:BG12184" /db_xref="UniProtKB/Swiss-Prot:Q797E6" /translation="MDVFSEYLAGIADPFHRERTEEVLTWIKNKYPNLHTEIKWNQPM FTDHGTFIIGFSVSKKHLAVAPEKVTIAHVEDDIVKAGYDYTEQLIRIPWNGPVDYTL LEKMIEFNILDKADCSTFWRK*" gene 621847..622218 /gene="fra" /locus_tag="BSU_05750" /old_locus_tag="BSU05750" downshifts 622197 /Source="Nicolas_upshifts" /id="D278" /incds=0 /nref=9 /ntot=150 /MaxReadThrough="2.88587" /MaxDrop="3.59127" /score="28.8500849" /energy="-8.1" /TU="NA" /idTUdmin="U448" /TUdmin=0 /isTUend="TRUE" downshifts complement(622292) /Source="Nicolas_upshifts" /id="D279" /incds=0 /nref=9 /ntot=187 /MaxReadThrough="1.63268" /MaxDrop="2.98181" /score="0.51805655" /energy="-13" /TU="NA" /idTUdmin="U450" /TUdmin=2 /isTUend="TRUE" CDS complement(622293..622790) /gene="ydhH" /locus_tag="BSU_05760" /old_locus_tag="BSU05760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388457.1" /db_xref="EnsemblGenomes-Gn:BSU05760" /db_xref="EnsemblGenomes-Tr:CAB12395" /db_xref="GOA:O05500" /db_xref="InterPro:IPR032545" /db_xref="SubtiList:BG12185" /db_xref="UniProtKB/Swiss-Prot:O05500" /translation="MSSHYKYPLIFTAFLLIAFCLIFFSYHLIHHVRLEYPNWQGESK DQNWEAVFTKNEDAPNEYSGKLYWIGDTIEIDNTYLESLIVKKDDEVLLSSDTEIPMH DYAGGTFSDGSAKEKSVSFLERLDEHELEGHDITIEVKWKQGNHYSASQLTLNEKTLF DEKQQ*" gene complement(622293..622790) /gene="ydhH" /locus_tag="BSU_05760" /old_locus_tag="BSU05760" CDS complement(622808..623290) /gene="ydhI" /locus_tag="BSU_05770" /old_locus_tag="BSU05770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388458.1" /db_xref="EnsemblGenomes-Gn:BSU05770" /db_xref="EnsemblGenomes-Tr:CAB12396" /db_xref="GOA:O05501" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12186" /db_xref="UniProtKB/Swiss-Prot:O05501" /translation="MMIIIPNNEIAKHMLTDFFAKHWGTPEMAISSGIFRCDELDGFA AVNESGEIIGCITYTIDGKDCEIISLDSMIENKGIGTALLQQVEEKAKHAHCQRIKLI TTNDNVNAIAFYQKRGYQFAAVFPNAVEKARRLKPEIPEVAENGILIRDEILFSKVID *" gene complement(622808..623290) /gene="ydhI" /locus_tag="BSU_05770" /old_locus_tag="BSU05770" promotor_-35 622963..622970 /Source="Nicolas_upshift_promotors" /id="U449" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2430 /SigmaFactorBS="gaattgatagcctctcttttgataaaacgctatcgCATTTAC AttatcattcgttgTGATAAGCTTTATTCGTTGAcaatgtgcatgtttagccttctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 622984..623003 /Source="Nicolas_upshift_promotors" /id="U449" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2430 /SigmaFactorBS="gaattgatagcctctcttttgataaaacgctatcgCATTTAC AttatcattcgttgTGATAAGCTTTATTCGTTGAcaatgtgcatgtttagccttctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 622988 /Source="Nicolas_upshifts" /id="U449" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2430 /SigmaFactorBS="gaattgatagcctctcttttgataaaacgctatcgCATTTAC AttatcattcgttgTGATAAGCTTTATTCGTTGAcaatgtgcatgtttagccttctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(623319..623338) /Source="Nicolas_upshift_promotors" /id="U450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=2264 /SigmaFactorBS="atatcgctgatttccatgccgtcacctcaacatCTATttttt ttgttatatATTGTTTATATTGATAGTACatatgcaatctttcaatagaggagtgtta t" /listShort="ydhI, ydhH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(623329) /Source="Nicolas_upshifts" /id="U450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=2264 /SigmaFactorBS="atatcgctgatttccatgccgtcacctcaacatCTATttttt ttgttatatATTGTTTATATTGATAGTACatatgcaatctttcaatagaggagtgtta t" /listShort="ydhI, ydhH" /GFF_Attribute="listLong" promotor_-35 complement(623353..623356) /Source="Nicolas_upshift_promotors" /id="U450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=2264 /SigmaFactorBS="atatcgctgatttccatgccgtcacctcaacatCTATttttt ttgttatatATTGTTTATATTGATAGTACatatgcaatctttcaatagaggagtgtta t" /listShort="ydhI, ydhH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 623373..624350 /gene="ydhJ" /locus_tag="BSU_05780" /old_locus_tag="BSU05780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent phosphohydrolase" /protein_id="NP_388459.1" /db_xref="EnsemblGenomes-Gn:BSU05780" /db_xref="EnsemblGenomes-Tr:CAB12397" /db_xref="GOA:O05502" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG12187" /db_xref="UniProtKB/Swiss-Prot:O05502" /translation="MEISDIIYGQHHIDGVLEELIKSAPVQRLKGIYQGGASFLVNRK WNVTRYEHSIGVMLLIKKLGGTIEEQIAGLLHDVSHTAFSHVVDVVFENQAEDYHENI FQQVIVHSEIPDILQKHGYHTEELLSDDSRWTLLEQPAPELCADRTDYTLRDMYRYGH INLHEAQTFLDHLIVRNGRMFPDSIEAAEWFVSVYYKEVIDFFLNPVNVYGYEYLARA LKAALRHDVISAEDLLKTDQEVLNILRASKNEEVLSLLTSIHPGIQVIEDDIQYDFHQ KKKMRLIDPSIFLDDKWIKSSGVSEKVRKMGEAAYQKAKKGVYIKILKQ*" gene 623373..624350 /gene="ydhJ" /locus_tag="BSU_05780" /old_locus_tag="BSU05780" downshifts 624330 /Source="Nicolas_upshifts" /id="D280" /incds=0 /nref=2 /ntot=92 /MaxReadThrough="2.31799" /MaxDrop="3.19063" /score="28.8500849" /energy="-8.1" /TU="NA" /idTUdmin="U451" /TUdmin="-770" /isTUend="FALSE" promotor_-35 624377..624383 /Source="Nicolas_upshift_promotors" /id="U451" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=176 /SigmaFactorBS="agtaattgccgcctgacagcggctttttttaTGTTTGGcttt gcaaacaaagGGGAATAGGACAAACTGCGggaacgctttatgagaatatcagcgtatt t" /listShort="ydhK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 624398..624416 /Source="Nicolas_upshift_promotors" /id="U451" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=176 /SigmaFactorBS="agtaattgccgcctgacagcggctttttttaTGTTTGGcttt gcaaacaaagGGGAATAGGACAAACTGCGggaacgctttatgagaatatcagcgtatt t" /listShort="ydhK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 624406 /Source="Nicolas_upshifts" /id="U451" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=176 /SigmaFactorBS="agtaattgccgcctgacagcggctttttttaTGTTTGGcttt gcaaacaaagGGGAATAGGACAAACTGCGggaacgctttatgagaatatcagcgtatt t" /listShort="ydhK" /GFF_Attribute="listLong" promotor_-35 624442..624449 /Source="Nicolas_upshift_promotors" /id="U452" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.434565434565435" /psig="0.98001998001998" /xcortree=1765 /SigmaFactorBS="ataggacaaactgcgggaacgctttatgagaatatcagcgTA TTTACAtaccgttcgggggTATAGTATTATCGAGAGGGCatgttttcattgtctgcgg g" /listShort="ydhK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 624462 /Source="Nicolas_upshifts" /id="U452" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.434565434565435" /psig="0.98001998001998" /xcortree=1765 /SigmaFactorBS="ataggacaaactgcgggaacgctttatgagaatatcagcgTA TTTACAtaccgttcgggggTATAGTATTATCGAGAGGGCatgttttcattgtctgcgg g" /listShort="ydhK" /GFF_Attribute="listLong" promotor_-10 624463..624482 /Source="Nicolas_upshift_promotors" /id="U452" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.434565434565435" /psig="0.98001998001998" /xcortree=1765 /SigmaFactorBS="ataggacaaactgcgggaacgctttatgagaatatcagcgTA TTTACAtaccgttcgggggTATAGTATTATCGAGAGGGCatgttttcattgtctgcgg g" /listShort="ydhK" /GFF_Attribute="listLong" /label="promotor_-10" CDS 624492..625109 /gene="ydhK" /locus_tag="BSU_05790" /old_locus_tag="BSU05790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388460.1" /db_xref="EnsemblGenomes-Gn:BSU05790" /db_xref="EnsemblGenomes-Tr:CAB12398" /db_xref="InterPro:IPR011438" /db_xref="PDB:2KY9" /db_xref="PDB:4FIB" /db_xref="PDB:4MDW" /db_xref="SubtiList:BG12188" /db_xref="UniProtKB/Swiss-Prot:O05503" /translation="MSAGKSYRKKMKQRRMNMKISKYALGILMLSLVFVLSACGNNNS TKESTHDNHSDSSTHEEMDHSGSADVPEGLQESKNPKYKVGSQVIINTSHMKGMKGAE ATVTGAYDTTAYVVSYTPTNGGQRVDHHKWVIQEEIKDAGDKTLQPGDQVILEASHMK GMKGATAEIDSAEKTTVYMVDYTSTTSGEKVKNHKWVTEDELSAK*" gene 624492..625109 /gene="ydhK" /locus_tag="BSU_05790" /old_locus_tag="BSU05790" downshifts 625096 /Source="Nicolas_upshifts" /id="D281" /incds=0 /nref=62 /ntot=212 /MaxReadThrough="1.07295" /MaxDrop="7.27889" /score="30.3859931" /energy="-11.4" /TU="U452" /idTUdmin="U451" /TUdmin="-4" /isTUend="TRUE" CDS complement(625125..626291) /gene="pbuE" /locus_tag="BSU_05800" /old_locus_tag="BSU05800" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12923093, 15849754, 16850406, 17935948, 25573585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923093, 15849754, 16850406, 17935948, 25573585; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine efflux transporter" /protein_id="NP_388461.2" /db_xref="EnsemblGenomes-Gn:BSU05800" /db_xref="EnsemblGenomes-Tr:CAB12399" /db_xref="GOA:Q797E3" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12189" /db_xref="UniProtKB/Swiss-Prot:Q797E3" /translation="MNFKVFLLAASTIAVGLVELIVGGILPQIANDLDISIVSAGQLI SVFALGYAVSGPLLLALTAKIERKRLYLIALFVFFLSNLVAYFSPNFATLMVSRVLAA MSTGLIVVLSLTIAPKIVAPEYRARAIGIIFMGFSSAIALGVPLGILISDSFGWRILF LGIGLLALISMLIISIFFERIPAEKMIPFREQLKTIGNLKIASSHLVTMFTLAGHYTL YAYFAPFLEETLHLSSFWVSICYFLFGISAVCGGPFGGALSDRLGSFKSILLVTGSFA IIMFLLPLSTSSMIFFLPVMVIWGLLSWSLAPAQQSYLIEIAPDSSDIQQSFNTSALQ VGIALGSAIGGVVLDQTGTVVSTAWCGGSIVIIAVLFAFISLTRPVQTAKKSSL*" gene complement(625125..626291) /gene="pbuE" /locus_tag="BSU_05800" /old_locus_tag="BSU05800" downshifts complement(625154) /Source="Nicolas_upshifts" /id="D282" /incds=0 /nref=40 /ntot=58 /MaxReadThrough="2.22188" /MaxDrop="4.89202" /score="36.362851" /energy="-12.4" /TU="NA" /idTUdmin="U453" /TUdmin=0 /isTUend="TRUE" misc_RNA complement(626346..626446) /gene="aswA" /locus_tag="BSU_misc_RNA_8" /product="adenine riboswitch" /experiment="publication(s) with functional evidences, PMID:14718920, 16201765, 19603494, 20022916, 21283784, 23087247, 25573585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14718920, 16201765, 19603494, 20022916, 21283784, 23087247, 25573585; Product type n: RNA" gene complement(626346..626446) /gene="aswA" /locus_tag="BSU_misc_RNA_8" downshifts complement(626387) /Source="Nicolas_upshifts" /id="D283" /incds=0 /nref=38 /ntot=127 /MaxReadThrough="5.85661" /MaxDrop="6.06248" /score="33.0784595" /energy="-19.4" /TU="U453" /idTUdmin="U453" /TUdmin="-1233" /isTUend="FALSE" promotor_-10 complement(626456..626475) /Source="Nicolas_upshift_promotors" /id="U453" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2453 /SigmaFactorBS="tatttttttccggttcaccgttttataaatttttcTATGGaa gattcattcataaTGTGGTACACTCATCAACGGaaacgaatcaattaaatagctatta t" /listShort="NA, pbuE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(626470) /Source="Nicolas_upshifts" /id="U453" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2453 /SigmaFactorBS="tatttttttccggttcaccgttttataaatttttcTATGGaa gattcattcataaTGTGGTACACTCATCAACGGaaacgaatcaattaaatagctatta t" /listShort="NA, pbuE" /GFF_Attribute="listLong" promotor_-35 complement(626491..626495) /Source="Nicolas_upshift_promotors" /id="U453" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2453 /SigmaFactorBS="tatttttttccggttcaccgttttataaatttttcTATGGaa gattcattcataaTGTGGTACACTCATCAACGGaaacgaatcaattaaatagctatta t" /listShort="NA, pbuE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 626554..626561 /Source="Nicolas_upshift_promotors" /id="U454" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=1575 /SigmaFactorBS="aaaaaaatatgattatatttattttataaaagTATAGACAtt taaaattaaatGACTATAATAATCAATGTAAgcgttttaataacaggggggatagcag t" /listShort="gmuB, gmuA, gmuC, gmuD, S203, gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 626575..626594 /Source="Nicolas_upshift_promotors" /id="U454" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=1575 /SigmaFactorBS="aaaaaaatatgattatatttattttataaaagTATAGACAtt taaaattaaatGACTATAATAATCAATGTAAgcgttttaataacaggggggatagcag t" /listShort="gmuB, gmuA, gmuC, gmuD, S203, gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 626582 /Source="Nicolas_upshifts" /id="U454" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=1575 /SigmaFactorBS="aaaaaaatatgattatatttattttataaaagTATAGACAtt taaaattaaatGACTATAATAATCAATGTAAgcgttttaataacaggggggatagcag t" /listShort="gmuB, gmuA, gmuC, gmuD, S203, gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" CDS 626622..626933 /gene="gmuB" /locus_tag="BSU_05810" /old_locus_tag="BSU05810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18177310; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligo-alpha-mannoside phosphotransferase system enzyme IIB" /protein_id="NP_388462.1" /db_xref="EnsemblGenomes-Gn:BSU05810" /db_xref="EnsemblGenomes-Tr:CAB12400" /db_xref="GOA:O05505" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR013012" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG12190" /db_xref="UniProtKB/Swiss-Prot:O05505" /translation="MKKILLACSSGMSTSLLVTKMKEYAQSIGEEAEIWAVGQDKAKE DMRKADAVLIGPQMSFLKSELQKEADQYNIQVEVIDMMAYGMADGKKAYEQALSLMVN Q*" gene 626622..626933 /gene="gmuB" /locus_tag="BSU_05810" /old_locus_tag="BSU05810" CDS 626933..627265 /gene="gmuA" /locus_tag="BSU_05820" /old_locus_tag="BSU05820" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligo-alpha-mannoside phosphotransferase system enzyme IIA" /protein_id="NP_388463.2" /db_xref="EnsemblGenomes-Gn:BSU05820" /db_xref="EnsemblGenomes-Tr:CAB12401" /db_xref="GOA:O05506" /db_xref="InterPro:IPR003188" /db_xref="InterPro:IPR036542" /db_xref="SubtiList:BG12191" /db_xref="UniProtKB/Swiss-Prot:O05506" /translation="MEQMKITNLTDEQISFQLILHSGNARSCIIQSLRAYKEGKKDEA DALIAKAEQDLSAAHDIHFQMIQKESGGEATAFSLLLMHAEDHLMSTLSMKELVKEML DLFKTKNI*" gene 626933..627265 /gene="gmuA" /locus_tag="BSU_05820" /old_locus_tag="BSU05820" CDS 627284..628612 /gene="gmuC" /locus_tag="BSU_05830" /old_locus_tag="BSU05830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 18177310; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligo-alpha-mannoside phosphotransferase system enzyme IIC" /protein_id="NP_388464.1" /db_xref="EnsemblGenomes-Gn:BSU05830" /db_xref="EnsemblGenomes-Tr:CAB12402" /db_xref="GOA:O05507" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG12192" /db_xref="UniProtKB/Swiss-Prot:O05507" /translation="MFEKISQFLVPIAGRLNNNRYLQVLRDAFMLAFPLTIFGSIFVV LTNLPFLNKIMNASMLTSFQSHFGIASTATMGIMSVFVVFGIGYYLSKSYQVEAVFGG AIALVSFLLLTPFIIQPETGDAITGVIPVDRLGAKGMFLGMITAFLSGEIYRRIVQKN LTIKMPAGVPPAVAKSFAALIPAFITLTVFLLINVMVTLFFKTNMHDVIYHAIQAPLV GLGSGIIPTLIAVFFIQILWFFGLHGQIIINSVMDPIWNTLQVENLSAYTAGKEIPHI ISKPFMEIYTVGMGGTGMTLAIVFTILIFMKSRQMKQVSKLGLAPGIFNVNEPIIFGL PIVMNPIIIVPWVLAPMVVTLVTYLAMSAGLVPPPTGVTVPWTVPLFINGIMATNSIM GGVMQLINLLIVFVIWFPFLKAMDKLNLAKEKEQAVQETAAQQNDNSIKM*" gene 627284..628612 /gene="gmuC" /locus_tag="BSU_05830" /old_locus_tag="BSU05830" CDS 628630..630027 /gene="gmuD" /locus_tag="BSU_05840" /old_locus_tag="BSU05840" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916, 18177310" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916, 18177310; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannoside-phospho-beta-d-glucosidase" /protein_id="NP_388465.1" /db_xref="EnsemblGenomes-Gn:BSU05840" /db_xref="EnsemblGenomes-Tr:CAB12403" /db_xref="GOA:O05508" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="SubtiList:BG12193" /db_xref="UniProtKB/Swiss-Prot:O05508" /translation="MAHTEQYRFPKDFWWGSSASATQMEGAADRDGKGQNIWDYWFEK EPHRFFDHVGPADTSQFYDNYKEDIRLMKELGHNSFRMSISWSRLIPNGTGEINDKAA DFYNNVIDELIANGIEPFVNLFHFDMPMALQKIGGWVNRETVDAYENYARTCFRLFGG RVKKWFTHNEPIVPVEGGYLYDFHYPNKVDFKEAVQVGFHTMLSSARAIQAYREMKQD GKIGIILNLTPSYPRSSHPADVKAGEIADAFFNRSFLDPSVKGEFPKELVDILKHEGF MPDYNAEDLDIIKKNTVDLLGVNYYQPRRVKAKEHLPNPDAPFLPDRYFDPYVMPGRK MNPHRGWEIYEKGVYDILINLKENYGNIECFISENGMGVEGEERFRDEQGIIQDDYRI EFIKEHLKWIHRAIQEGSNVKGYHLWTFMDNWSWTNAYKNRYGFVSVNLEKDGERTVK KSGKWFKEVAEHSGF*" gene 628630..630027 /gene="gmuD" /locus_tag="BSU_05840" /old_locus_tag="BSU05840" S_feature 630028..630114 /Source="Nicolas_S_feature" /locus_tag="new_630028_630114" /HighExp="G150, T0.30H, T1.0H, M40t90, T1.30H, Mt0, M0t90, Lbexp, dia0, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S203" promotor_-35 630092..630099 /Source="Nicolas_upshift_promotors" /id="U455" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig="0.997002997002997" /xcortree=640 /SigmaFactorBS="aatcatcataacgaatagagatgacgaaaatccgcaACATTG ATgaaatagggaaaaGAACTTATGATATCCGTAAAagcttatgtgatatcaaacagct g" /listShort="gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 630113..630132 /Source="Nicolas_upshift_promotors" /id="U455" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig="0.997002997002997" /xcortree=640 /SigmaFactorBS="aatcatcataacgaatagagatgacgaaaatccgcaACATTG ATgaaatagggaaaaGAACTTATGATATCCGTAAAagcttatgtgatatcaaacagct g" /listShort="gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 630116 /Source="Nicolas_upshifts" /id="U455" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig="0.997002997002997" /xcortree=640 /SigmaFactorBS="aatcatcataacgaatagagatgacgaaaatccgcaACATTG ATgaaatagggaaaaGAACTTATGATATCCGTAAAagcttatgtgatatcaaacagct g" /listShort="gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" CDS 630170..630883 /gene="gmuR" /locus_tag="BSU_05850" /old_locus_tag="BSU05850" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18177310" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18177310; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_388466.1" /db_xref="EnsemblGenomes-Gn:BSU05850" /db_xref="EnsemblGenomes-Tr:CAB12404" /db_xref="GOA:O05509" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12194" /db_xref="UniProtKB/Swiss-Prot:O05509" /translation="MNKYEIIANEMRNRIKNNVYPIDQPIPDEVSLAKEFNSSRMTMK RALDNLVAEGLLFRKRGHGTFIIQSAIQDDHVHVVSNEILGLTNLLKDKKIKSKVIQF EVQFPTEEVAAHLSIDQKTPVYYVVRLRIVEGEPYVLEKTYMPTHLIPGINDDVLHDS IYNHITNVLQLKIAGTHRKIRACKSDHIDQQHLGCKQDDPILEVEHVGFLDTGIPFEY SFSRHRHDKFVVTSVNIRR*" gene 630170..630883 /gene="gmuR" /locus_tag="BSU_05850" /old_locus_tag="BSU05850" CDS 630912..631811 /gene="gmuE" /locus_tag="BSU_05860" /old_locus_tag="BSU05860" /EC_number="2.7.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15018644, 18177310, 21185308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15018644, 18177310, 21185308; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ROK fructokinase; glucomannan utilization protein E" /protein_id="NP_388467.1" /db_xref="EnsemblGenomes-Gn:BSU05860" /db_xref="EnsemblGenomes-Tr:CAB12405" /db_xref="GOA:O05510" /db_xref="InterPro:IPR000600" /db_xref="PDB:1XC3" /db_xref="PDB:3LM9" /db_xref="PDB:3OHR" /db_xref="SubtiList:BG12195" /db_xref="UniProtKB/Swiss-Prot:O05510" /translation="MLGGIEAGGTKFVCAVGREDGTIIDRIEFPTKMPDETIEKVIQY FSQFSLQAIGIGSFGPVDNDKTSQTYGTITATPKAGWRHYPFLQTVKNEMKIPVGFST DVNAAALGEFLFGEAKGLDSCLYITIGTGIGAGAIVEGRLLQGLSHPEMGHIYIRRHP DDVYQGKCPYHGDCFEGLASGPAIEARWGKKAADLSDIAQVWELEGYYIAQALAQYIL ILAPKKIILGGGVMQQKQVFSYIYQYVPKIMNSYLDFSELSDDISDYIVPPRLGSNAG IIGTLVLAHQALQAEAASGEVRS*" gene 630912..631811 /gene="gmuE" /locus_tag="BSU_05860" /old_locus_tag="BSU05860" CDS 631808..632755 /gene="gmuF" /locus_tag="BSU_05870" /old_locus_tag="BSU05870" /EC_number="5.3.1.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10704478, 18177310, 3017192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphohexomutase; cupin family" /protein_id="NP_388468.1" /db_xref="EnsemblGenomes-Gn:BSU05870" /db_xref="EnsemblGenomes-Tr:CAB12406" /db_xref="GOA:O05511" /db_xref="InterPro:IPR001250" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014628" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG12196" /db_xref="UniProtKB/Swiss-Prot:O05511" /translation="MTHPLFLEPVFKERLWGGTKLRDAFGYAIPSQKTGECWAVSAHA HGSSSVKNGPLAGKTLDQVWKDHPEIFGFPDGKVFPLLVKLLDANMDLSVQVHPDDDY AKLHENGDLGKTECWYIIDCKDDAELILGHHASTKEEFKQRIESGDWNGLLRRIKIKP GDFFYVPSGTLHALCKGTLVLEIQQNSDTTYRVYDYDRCNDQGQKRTLHIEKAMEVIT IPHIDKVHTPEVKEVGNAEIIVYVQSDYFSVYKWKISGRAAFPSYQTYLLGSVLSGSG RIINNGIQYECNAGSHFILPAHFGEFTIEGTCEFMISHP*" gene 631808..632755 /gene="gmuF" /locus_tag="BSU_05870" /old_locus_tag="BSU05870" CDS 632774..633862 /gene="gmuG" /locus_tag="BSU_05880" /old_locus_tag="BSU05880" /EC_number="3.2.1.78" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2694961, 7727534, 18177310, 28101462, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2694961, 7727534, 18177310, 28101462, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported mannan endo-1,4-beta-mannosidase" /protein_id="NP_388469.2" /db_xref="EnsemblGenomes-Gn:BSU05880" /db_xref="EnsemblGenomes-Tr:CAB12407" /db_xref="GOA:O05512" /db_xref="InterPro:IPR000805" /db_xref="InterPro:IPR016714" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR022790" /db_xref="PDB:2WHK" /db_xref="PDB:3CBW" /db_xref="SubtiList:BG12197" /db_xref="UniProtKB/Swiss-Prot:O05512" /translation="MFKKHTISLLIIFLLASAVLAKPIEAHTVSPVNPNAQQTTKTVM NWLAHLPNRTENRVLSGAFGGYSHDTFSMAEADRIRSATGQSPAIYGCDYARGWLETA NIEDSIDVSCNGDLMSYWKNGGIPQISLHLANPAFQSGHFKTPITNDQYKKILDSSTV EGKRLNAMLSKIADGLQELENQGVPVLFRPLHEMNGEWFWWGLTSYNQKDNERISLYK QLYKKIYHYMTDTRGLDHLIWVYSPDANRDFKTDFYPGASYVDIVGLDAYFQDAYSIN GYDQLTALNKPFAFTEVGPQTANGSFDYSLFINAIKQKYPKTIYFLAWNDEWSAAVNK GASALYHDSWTLNKGEIWNGDSLTPIVE*" gene 632774..633862 /gene="gmuG" /locus_tag="BSU_05880" /old_locus_tag="BSU05880" downshifts 633856 /Source="Nicolas_upshifts" /id="D284" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="1.56881" /MaxDrop="2.87204" /score="7.63230089" /energy="-5.4" /TU="NA" /idTUdmin="U454" /TUdmin=0 /isTUend="TRUE" CDS complement(633923..634651) /gene="ydhUc" /locus_tag="BSU_05890" /old_locus_tag="BSU05890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; C-terminal part of YhdU" /db_xref="SubtiList:BG12198" /translation="FFQSSNFRGKQKQYRDLLRGIFLEEIAHVELVQNTINALLDESG GEGVGSQGTDQAPLDEAVKHANPHHYIIGAQSSLPVDAGGNPWNGSWVYNHGNLITDL LDNLLLESTGVLQKTRIYEMSSNQTFRETLAFLIVRDNAHQNAFAKALETLGVEWAKL LPVPNYDINKYPECRKYVELGYHNTHFNFRLDETRISEIYQGKSPSRNGGELQVIDPP AGFPVPVLPEIPNEHSPGLGDMNA*" gene complement(633923..634651) /gene="ydhUc" /locus_tag="BSU_05890" /old_locus_tag="BSU05890" /pseudo downshifts complement(633973) /Source="Nicolas_upshifts" /id="D285" /incds=0 /nref=13 /ntot=37 /MaxReadThrough="1.1517" /MaxDrop="5.0503" /score="0.317473754" /energy="-17.6" /TU="NA" /idTUdmin="U456" /TUdmin=3 /isTUend="TRUE" CDS complement(634582..634776) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; N-terminal part of YhdU" /translation="MYYYKEELINIIKPDKPDPAAAKVLQEILGGHYGEMRTMMQFFS KALISEESRNSTAICFAAFF*" gene complement(634582..634776) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /pseudo promotor_-10 complement(634809..634820) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(634817) /Source="Nicolas_upshifts" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" promotor_-35 complement(634834..634840) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 634895..634902 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 634916..634935 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box 634918..635018 /Source="Nicolas_upshift_promotors" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 634920 /Source="Nicolas_upshifts" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" downshifts complement(634966) /Source="Nicolas_upshifts" /id="D286" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="2.24619" /MaxDrop="4.20389" /score="11.9939391" /energy="-9" /TU="NA" /idTUdmin="U456" /TUdmin="-990" /isTUend="FALSE" upshifts 634978 /Source="Nicolas_upshifts" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" promotor_-35 634986..634993 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 635007..635026 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 635022..635109 /Source="Nicolas_S_feature" /locus_tag="new_635022_635109" /HighExp="LBGstat, C30, Cold, Heat, Oxctl, T-1.10H, T-0.40H, T-1.40H, UNK1, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.96, 0.0919, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S204" upshifts 635022 /Source="Nicolas_upshifts" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" tRNA 635110..635186 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 635110..635186 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" tRNA 635200..635273 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(UCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 635200..635273 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" rRNA 635433..636987 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 635433..636987 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" rRNA 637155..640082 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 637155..640082 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" rRNA 640138..640254 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 640138..640254 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" tRNA 640268..640344 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 640268..640344 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" tRNA 640405..640481 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 640405..640481 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" downshifts 640478 /Source="Nicolas_upshifts" /id="D287" /incds=0 /nref=38 /ntot=211 /MaxReadThrough="6.00554" /MaxDrop="5.14761" /score="7.63230089" /energy="-5.4" /TU="NA" /idTUdmin="U460" /TUdmin="-3784" /isTUend="FALSE" promotor_-35 640582..640586 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 640602..640621 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 640606 /Source="Nicolas_upshifts" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" CDS 640662..641639 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" /EC_number="2.7.4.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-monophosphate kinase" /protein_id="NP_388471.1" /db_xref="EnsemblGenomes-Gn:BSU05900" /db_xref="EnsemblGenomes-Tr:CAB12409" /db_xref="GOA:O05514" /db_xref="InterPro:IPR006283" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10693" /db_xref="UniProtKB/Swiss-Prot:O05514" /translation="MDEFDLIHSITPRTIHHSSVDVGIGDDAALYTAKHGVQEIVCVD TMVEDVHFKLHYSSPEDIGYKALAVNISDIAAMGGIPKFYLVSLAVPSKWTESEIKAM YEGMNELAKLYHMDLIGGDTVSTADKLVVTVTVIGEIEKGQACLRSLAKPNDIVFVTG EIGSSAAGLSLLLEETNPQNSSVETDYFIHRHKRPEPRVSVGRLCSIFKRAALNDVSD GLASELNEIAEASCVSIEIVESMLPIHSDLPKLHPNWKEWALFGGEDFELTGTVSNEE WEVLKQECAALHLPITKIGYVREKTKSKVILKTDQTSMILEKKGYNHFK*" gene 640662..641639 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" CDS 641654..642130 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; ADP binding protein" /protein_id="NP_388472.1" /db_xref="EnsemblGenomes-Gn:BSU05910" /db_xref="EnsemblGenomes-Tr:CAB12410" /db_xref="GOA:O05515" /db_xref="InterPro:IPR003442" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12199" /db_xref="UniProtKB/Swiss-Prot:O05515" /translation="MKQLKWRTVNPEETKAIAKLTAAFAKPGDVLTLEGDLGAGKTTF TKGFAEGLGITRIVNSPTFTIIKEYNDGVLPLYHMDVYRMEDESEDLGLDEYFHGQGV CLVEWAHLIEEQLPQERLQIVIKRAGDDEREITFTAVGNRYEMLCEELSRHDNISN*" gene 641654..642130 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" CDS 642111..642800 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; protease involved in TsaD function" /protein_id="NP_388473.1" /db_xref="EnsemblGenomes-Gn:BSU05920" /db_xref="EnsemblGenomes-Tr:CAB12411" /db_xref="GOA:O05516" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR022496" /db_xref="SubtiList:BG12200" /db_xref="UniProtKB/Swiss-Prot:O05516" /translation="MTILAIDTSNYTLGIALLREDTVIAEYITYLKKNHSVRAMPAVH SLLNDCDMAPQDLSKIVVAKGPGSYTGVRIGVTLAKTLAWSLDIPISAVSSLETLAAN GRHFDGLISPIFDARRGQVYTGLYQYKNGLLEQVVPDQNVMLADWLEMLKEKDRPVLF LGHDTSLHKQMIEDVLGTKGFIGTAAQHNPRPSELAFLGKEKEAADVHGLVPDYLRLA EAEAKWIESQK*" gene 642111..642800 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" CDS 642810..643265 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" /EC_number="2.3.1.267" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2828880; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein S18 alanine N-acetyltransferase" /protein_id="NP_388474.1" /db_xref="EnsemblGenomes-Gn:BSU05930" /db_xref="EnsemblGenomes-Tr:CAB12412" /db_xref="GOA:O05517" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR006464" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12201" /db_xref="UniProtKB/Swiss-Prot:O05517" /translation="MKTKAAVRNMRLEDIDHVYEIEASSFTSPWTKDSFYHELLENPY AHYLVIEKDGHLAGYCGIWIVMDDAQITNIAIKPEYRGQSLGETLFRSAVELCKEKDA RRLSLEVRVSNHPAQGLYKKFGMQPGGIRKNYYTDNGEDALIMWVTINE*" gene 642810..643265 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" CDS 643258..644298 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11073929, 12682299, 9743119, 20824107, 21625506, 21873492, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; glycation binding protein" /protein_id="NP_388475.1" /db_xref="EnsemblGenomes-Gn:BSU05940" /db_xref="EnsemblGenomes-Tr:CAB12413" /db_xref="GOA:O05518" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR017860" /db_xref="InterPro:IPR017861" /db_xref="InterPro:IPR022450" /db_xref="SubtiList:BG12202" /db_xref="UniProtKB/Swiss-Prot:O05518" /translation="MSEQKDMYVLGIETSCDETAAAIVKNGKEIISNVVASQIESHKR FGGVVPEIASRHHVEQITLVIEEAFRKAGMTYSDIDAIAVTEGPGLVGALLIGVNAAK ALSFAYNIPLVGVHHIAGHIYANRLVEDIVFPALALVVSGGHTELVYMKEHGSFEVIG ETLDDAAGEAYDKVARTMGLPYPGGPQIDKLAEKGNDNIPLPRAWLEEGSYNFSFSGL KSAVINTLHNASQKGQEIAPEDLSASFQNSVIDVLVTKTARAAKEYDVKQVLLAGGVA ANRGLRAALEKEFAQHEGITLVIPPLALCTDNAAMIAAAGTIAFEKGIRGAYDMNGQP GLELTSYQSLTR*" gene 643258..644298 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" downshifts 644262 /Source="Nicolas_upshifts" /id="D288" /incds=0 /nref=39 /ntot=222 /MaxReadThrough="3.15518" /MaxDrop="4.65228" /score="3.97936019" /energy="-10.1" /TU="NA" /idTUdmin="U460" /TUdmin=0 /isTUend="TRUE" CDS complement(644528..646456) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11916677, 16109936, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388476.2" /db_xref="EnsemblGenomes-Gn:BSU05950" /db_xref="EnsemblGenomes-Tr:CAB12414" /db_xref="GOA:O05519" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12203" /db_xref="UniProtKB/Swiss-Prot:O05519" /translation="MMILQVNQLSKSFGADTILNNIKLEVRNRDRIAIVGRNGAGKST LLKIIAGQLSYEKGEIIKPKDITMGYLAQHTGLDSKLTIKEELLTVFDHLKAMEKEMR AMEEKMAAADPGELESIMKTYDRLQQEFKDKGGYQYEADVRSVLHGLGFSHFDDSTQV QSLSGGQKTRLALGKLLLTQPDLLILDEPTNHLDIDTLTWLEHYLQGYSGAILIVSHD RYFLDKVVNQVYEVSRAESKKYHGNYSAYLDQKAAQYEKDLKMYEKQQDEIAKLQDFV DRNLARASTTKRAQSRRKQLERMDVMSKPLGDEKSANFHFDITKQSGNEVLRVQDLTI SYENQPPLLTEVSFMLTRGESAALVGPNGIGKSTLLKTLIDTLKPDQGTISYGSNVSV GYYDQEQAELTSSKRVLDELWDEYPGLPEKEIRTCLGNFLFSGDDVLKPVHSLSGGEK ARLALAKLMLQKANFLILDEPTNHLDLDSKEVLENALIDYPGTLLFVSHDRYFINRIA TRVLELSSSHIEEYLGDYDYYTEKKTEQLELEKMNQQEETDKTPATVKSDSKRSYEEE KEWKKKERQRLRRIEEIETTVQTIEENISRNDELLCDPEVYQDHEKVQAIHADNEKLN QELESLLSEWEELSTEED*" gene complement(644528..646456) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" downshifts complement(644545) /Source="Nicolas_upshifts" /id="D289" /incds=0 /nref=170 /ntot=266 /MaxReadThrough="1.32926" /MaxDrop="5.81869" /score="16.702581" /energy="-12.6" /TU="NA" /idTUdmin="U463" /TUdmin="-9" /isTUend="TRUE" misc_feature 646208..646227 /Source="Nicolas_upshift_promotors" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 646218 /Source="Nicolas_upshifts" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" S_feature 646220..646409 /Source="Nicolas_S_feature" /locus_tag="new_646220_646409" /HighExp="Diami, H2O2, dia5, Paraq, G135, G180, G150, Cold, dia15, BC" /AntisenseName="ydiF" /AntisenseCor="0.47406689574609401" /AntisenseRegPval="-15.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S205" promotor_-35 646374..646381 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 646395..646414 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 646411..646581 /Source="Nicolas_S_feature" /locus_tag="new_646411_646581" /HighExp="Diami, dia5, dia15, H2O2, Etha, G180, G150, Oxctl, Mt0, Paraq" /AntisenseName="ydiF" /AntisenseCor="0.63697451027099605" /AntisenseRegPval="-31.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S206" upshifts 646411 /Source="Nicolas_upshifts" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" promotor_-10 complement(646476..646495) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(646488) /Source="Nicolas_upshifts" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" promotor_-35 complement(646509..646516) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 646582..647094 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" /EC_number="4.6.1.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10903949, 16632608, 18607082, 20606263, 25941396, 26575208; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdenum cofactor biosynthesis protein C" /protein_id="NP_388477.1" /db_xref="EnsemblGenomes-Gn:BSU05960" /db_xref="EnsemblGenomes-Tr:CAB12415" /db_xref="GOA:O05520" /db_xref="InterPro:IPR002820" /db_xref="InterPro:IPR023045" /db_xref="InterPro:IPR036522" /db_xref="SubtiList:BG12204" /db_xref="UniProtKB/Swiss-Prot:O05520" /translation="MNGFSHFNEQGRAQMVDISEKSSTVRTAAAVSSVHMKNEVYEKI QSHDIGKGDVLAVAQVAGIMAAKQTSNIIPMCHPLSLSGVDISFDWKIKEAEVILHIK AQVKTKGSTGVEMEALTSASVCALTVYDMCKALDKGMVIGPTFLLEKTGGKNGDFKRE LSEYNLEDQK*" gene 646582..647094 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" CDS 647091..647738 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription repressor of cydABCD and yjlC-ndh expression" /protein_id="NP_388478.1" /db_xref="EnsemblGenomes-Gn:BSU05970" /db_xref="EnsemblGenomes-Tr:CAB12416" /db_xref="GOA:O05521" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR009718" /db_xref="InterPro:IPR022876" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2VT2" /db_xref="PDB:2VT3" /db_xref="SubtiList:BG12205" /db_xref="UniProtKB/Swiss-Prot:O05521" /translation="MNKDQSKIPQATAKRLPLYYRFLKNLHASGKQRVSSAELSDAVK VDSATIRRDFSYFGALGKKGYGYNVDYLLSFFRKTLDQDEMTDVILIGVGNLGTAFLH YNFTKNNNTKISMAFDINESKIGTEVGGVPVYNLDDLEQHVKDESVAILTVPAVAAQS ITDRLVALGIKGILNFTPARLNVPEHIRIHHIDLAVELQSLVYFLKHYSVLEEIE*" gene 647091..647738 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" promotor_no_box 647568..647668 /Source="Nicolas_upshift_promotors" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 647628 /Source="Nicolas_upshifts" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" CDS 647760..647933 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388479.1" /db_xref="EnsemblGenomes-Gn:BSU05980" /db_xref="EnsemblGenomes-Tr:CAB12417" /db_xref="GOA:O05522" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG12206" /db_xref="UniProtKB/Swiss-Prot:O05522" /translation="MPIGPGSLAVIAIVALIIFGPKKLPELGKAAGDTLREFKNATKG LTSDEEEKKKEDQ*" gene 647760..647933 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" CDS 647940..648704 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11007775, 15187182, 15849754, 16850406, 19049517, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007775, 15187182, 15849754, 16850406, 19049517, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388480.1" /db_xref="EnsemblGenomes-Gn:BSU05990" /db_xref="EnsemblGenomes-Tr:CAB12418" /db_xref="GOA:O05523" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG12207" /db_xref="UniProtKB/Swiss-Prot:O05523" /translation="MTRMKVNQMSLLEHIAELRKRLLIVALAFVVFFIAGFFLAKPII VYLQETDEAKQLTLNAFNLTDPLYVFMQFAFIIGIVLTSPVILYQLWAFVSPGLYEKE RKVTLSYIPVSILLFLAGLSFSYYILFPFVVDFMKRISQDLNVNQVIGINEYFHFLLQ LTIPFGLLFQMPVILMFLTRLGIVTPMFLAKIRKYAYFTLLVIAALITPPELLSHMMV TVPLLILYEISILISKAAYRKAQKSSAADRDVSSGQ*" gene 647940..648704 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" downshifts 648684 /Source="Nicolas_upshifts" /id="D290" /incds=0 /nref=151 /ntot=251 /MaxReadThrough="4.01237" /MaxDrop="6.80817" /score="19.4098216" /energy="-12.7" /TU="NA" /idTUdmin="U461" /TUdmin=0 /isTUend="TRUE" CDS complement(648742..648933) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388481.1" /db_xref="EnsemblGenomes-Gn:BSU06000" /db_xref="EnsemblGenomes-Tr:CAB12419" /db_xref="GOA:O05524" /db_xref="InterPro:IPR025426" /db_xref="SubtiList:BG12208" /db_xref="UniProtKB/Swiss-Prot:O05524" /translation="MRNPVVWGMIYFAVGCIFTYLAASSPGSMWSFYSILLMVFAAYN ISISFKMFAFSFKIKKNQK*" gene complement(648742..648933) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" downshifts complement(648759) /Source="Nicolas_upshifts" /id="D291" /incds=0 /nref=211 /ntot=258 /MaxReadThrough="0.81338" /MaxDrop="6.43897" /score="25.5376889" /energy="-12.7" /TU="NA" /idTUdmin="U467" /TUdmin="-21" /isTUend="TRUE" CDS complement(648930..649664) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" /EC_number="3.4.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_388482.1" /db_xref="EnsemblGenomes-Gn:BSU06010" /db_xref="EnsemblGenomes-Tr:CAB12420" /db_xref="GOA:O05525" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG12209" /db_xref="UniProtKB/Swiss-Prot:O05525" /translation="MRKQYWFIILTYIIMQFSALIAIPLLFKFGYAGGQPTDENMLHA QGLWSVISFIACLVVVLLILRTVPKETLRNGQKDSIGLSILWAIAGFFIALFSQGIAG SIEYYVFGIGRESENTQAILDVIQAVPLMIIVSSIVGPILEEIIFRKIIFGALYEKTN FFFAGLISSVIFGIVHADLKHLLLYTAMGFTFAFLYARTKRIWVPIFAHLMMNTFVVI MQLEPVRNYLEQQSTQMQLIIGGLFL*" gene complement(648930..649664) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" promotor_-35 649322..649327 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 649342..649360 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 649344 /Source="Nicolas_upshifts" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 649663..649664 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-35" promotor_-10 649674..649688 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-10" upshifts 649696 /Source="Nicolas_upshifts" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" promotor_-10 complement(649701..649720) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 649718..649826 /Source="Nicolas_S_feature" /locus_tag="new_649718_649826" /HighExp="S4, S5, H2O2, S3, S8, S6, Diami, Oxctl, G180, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.238" /TUlongSig="NA" /TUlongPSig="NA" /label="S207" upshifts complement(649721) /Source="Nicolas_upshifts" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" promotor_-35 complement(649734..649739) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 649800..649806 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 649820..649839 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 649828..649902 /Source="Nicolas_S_feature" /locus_tag="new_649828_649902" /HighExp="HiTm, Etha, dia15, Heat, C90, dia5, LoTm, Lbexp, H2O2, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S208" upshifts 649828 /Source="Nicolas_upshifts" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" CDS 649903..650187 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11407116, 17031040, 9303302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11407116, 17031040, 9303302; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin small subunit" /protein_id="NP_388483.2" /db_xref="EnsemblGenomes-Gn:BSU06020" /db_xref="EnsemblGenomes-Tr:CAB12421" /db_xref="GOA:P28599" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR018369" /db_xref="InterPro:IPR020818" /db_xref="InterPro:IPR037124" /db_xref="SubtiList:BG10422" /db_xref="UniProtKB/Swiss-Prot:P28599" /translation="MLKPLGDRVVIELVESEEKTASGIVLPDSAKEKPQEGKIVAAGS GRVLESGERVALEVKEGDRIIFSKYAGTEVKYEGTEYLILRESDILAVIG*" gene 649903..650187 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" CDS 650234..651868 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9303302, 11407116, 17031040, 17420574, 22268681" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 11407116, 17031040, 17420574, 22268681; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin large subunit" /protein_id="NP_388484.1" /db_xref="EnsemblGenomes-Gn:BSU06030" /db_xref="EnsemblGenomes-Tr:CAB12422" /db_xref="GOA:P28598" /db_xref="InterPro:IPR001844" /db_xref="InterPro:IPR002423" /db_xref="InterPro:IPR018370" /db_xref="InterPro:IPR027409" /db_xref="InterPro:IPR027410" /db_xref="InterPro:IPR027413" /db_xref="SubtiList:BG10423" /db_xref="UniProtKB/Swiss-Prot:P28598" /translation="MAKEIKFSEEARRAMLRGVDALADAVKVTLGPKGRNVVLEKKFG SPLITNDGVTIAKEIELEDAFENMGAKLVAEVASKTNDVAGDGTTTATVLAQAMIREG LKNVTAGANPVGVRKGMEQAVAVAIENLKEISKPIEGKESIAQVAAISAADEEVGSLI AEAMERVGNDGVITIEESKGFTTELEVVEGMQFDRGYASPYMVTDSDKMEAVLDNPYI LITDKKITNIQEILPVLEQVVQQGKPLLLIAEDVEGEALATLVVNKLRGTFNAVAVKA PGFGDRRKAMLEDIAVLTGGEVITEDLGLDLKSTQIAQLGRASKVVVTKENTTIVEGA GETDKISARVTQIRAQVEETTSEFDREKLQERLAKLAGGVAVIKVGAATETELKERKL RIEDALNSTRAAVEEGIVSGGGTALVNVYNKVAAVEAEGDAQTGINIVLRALEEPIRQ IAHNAGLEGSVIVERLKNEEIGVGFNAATGEWVNMIEKGIVDPTKVTRSALQNAASVA AMFLTTEAVVADKPEENGGGAGMPDMGGMGGMGGMM*" gene 650234..651868 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" S_feature 651869..651961 /Source="Nicolas_S_feature" /locus_tag="new_651869_651961" /HighExp="HiTm, Etha, dia15, Heat, Diami, dia5, C90, S1, S2, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S209" downshifts 651918 /Source="Nicolas_upshifts" /id="D292" /incds=0 /nref=228 /ntot=267 /MaxReadThrough="6.24882" /MaxDrop="5.77437" /score="-6.71161833" /energy="-16.3" /TU="U468" /idTUdmin="U466" /TUdmin=2112 /isTUend="FALSE" CDS complement(651956..652084) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); C-terminal part of YdzT; defective prophage 3" /translation="EAGVGIKEIQQQFGHSDINTTMDIYAHMTANMEKRSPNSLVN*" gene complement(651956..652084) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /pseudo S_feature 651963..653431 /Source="Nicolas_S_feature" /locus_tag="new_651963_653431" /HighExp="H2O2, Heat, dia15, Diami, S1, G135, G150, S2, G180, dia5" /AntisenseName="ydzT" /AntisenseCor="-2.9485116084752801E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="0.23100000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S210" CDS complement(652087..652245) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52563.1" /translation="MIYQDSSFIFEREDGHPQLRKVIETRLKRLLKKAGIKRMSPPTL LGIPIPPY*" gene complement(652087..652245) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /pseudo CDS complement(652290..652418) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52564.1" /translation="MISQVTKTLYTPNNQIEKYQLLTPKTTGSVDIVRIDETMSIY*" gene complement(652290..652418) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /pseudo CDS complement(652511..652720) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52565.1" /translation="MYEDRTLELNEQYSHNCLGGIHACGRMIFRKAKTQGIIKMNPTG DFQLPKKQQSIGKRGADTFSKARSI*" gene complement(652511..652720) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /pseudo CDS complement(652713..653018) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); N-terminal part of YdzT; defective prophage 3" /db_xref="PSEUDO:CAX52566.1" /translation="MELSYLLGIDPLTKKRLEISKGRFKTKKEAPVAARHVELQNDNG TFIKESDMPFKTFAKGWLKIYNRSGVKISSVRASEKKMMHFIAVLGQYPISKTQKNV* " gene complement(652713..653018) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /pseudo CDS 653432..653812 /gene="ydiM" /locus_tag="BSU_06040" /old_locus_tag="BSU06040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein; prophage 3 region" /protein_id="NP_388485.1" /db_xref="EnsemblGenomes-Gn:BSU06040" /db_xref="EnsemblGenomes-Tr:CAB12423" /db_xref="SubtiList:BG12785" /db_xref="UniProtKB/Swiss-Prot:O34672" /translation="MLSDNNFVSETLENVQYLLPGAKVIKLRGYSRAHKVYTIAKSPV EKWKVAAGLSGSEIAILIRKGHWIGASIPAGGIVIDIDDSKQGELVKGLLDAQNFHCH CIRTLMGGSLFLRITNMGKRKLNK*" gene 653432..653812 /gene="ydiM" /locus_tag="BSU_06040" /old_locus_tag="BSU06040" S_feature 653813..654070 /Source="Nicolas_S_feature" /locus_tag="new_653813_654070" /HighExp="H2O2, dia15, S1, Heat, G150, Diami, G135, G180, S2, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.1454" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S211" CDS 654071..654343 /gene="ydzU" /locus_tag="BSU_06048" /old_locus_tag="BSU06048" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein; prophage 3 region" /protein_id="YP_003097688.1" /db_xref="EnsemblGenomes-Gn:BSU06048" /db_xref="EnsemblGenomes-Tr:CAX52567" /db_xref="UniProtKB/Swiss-Prot:C0H3W7" /translation="MKAWKVEPYEISKAMELIYKYLLLDKKDFSLEEFYKLTIYAIKW KLEQAQFPLYLESTKKSHQNVIPQPFKIKGNVLYKTVIKNSGDFEE*" gene 654071..654343 /gene="ydzU" /locus_tag="BSU_06048" /old_locus_tag="BSU06048" CDS 654333..654692 /gene="ydzV" /locus_tag="BSU_06049" /old_locus_tag="BSU06049" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type h : extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage terminase (fragment); defective prophage 3" /db_xref="PSEUDO:CAX52568.1" /translation="MKNSSSWRVGVIHPFKKLSNIERNSVHYELASNDNGREKKDIVP ASVISPSGSCFSLADNGLVEKEGQKMKLTERQRRFCDFFTETRNTTEATRLAGNKGKN LNRVASQNLSKLDIQTI*" gene 654333..654692 /gene="ydzV" /locus_tag="BSU_06049" /old_locus_tag="BSU06049" /pseudo S_feature 654693..655136 /Source="Nicolas_S_feature" /locus_tag="new_654693_655136" /HighExp="H2O2, dia15, S1, G180, G135, G150, Heat, Diami, S2, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S212" CDS 654978..655193 /gene="ydiN" /locus_tag="BSU_06050" /old_locus_tag="BSU06050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative N-terminus of restriction enzyme; defective prophage 3" /db_xref="PSEUDO:SOX90546.1" /translation="MIKFSVILGMIRCSLTHITTKNTVNALKRMIYPKQKPSFFHEFK VLYKLLKKFCIKGIMIKNIRSCMGYFL*" gene 654978..655193 /gene="ydiN" /locus_tag="BSU_06050" /old_locus_tag="BSU06050" /pseudo promotor_-35 655123..655129 /Source="Nicolas_upshift_promotors" /id="U469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig="0.997002997002997" /xcortree=1874 /SigmaFactorBS="agcaaaaaccttcattctttcatgaatttaaagtattatata agcTACTGAAaaagttttgtataAAAGGTATAATGATAAAGAAcattcgttcttgtat g" /listShort="S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 655138..655222 /Source="Nicolas_S_feature" /locus_tag="new_655138_655222" /HighExp="Diami, H2O2, dia5, dia15, Salt, M40t45, G180, G150, G135, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S213" upshifts 655138 /Source="Nicolas_upshifts" /id="U469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig="0.997002997002997" /xcortree=1874 /SigmaFactorBS="agcaaaaaccttcattctttcatgaatttaaagtattatata agcTACTGAAaaagttttgtataAAAGGTATAATGATAAAGAAcattcgttcttgtat g" /listShort="S213, ydiO, ydiP" /GFF_Attribute="listLong" promotor_-10 655143..655162 /Source="Nicolas_upshift_promotors" /id="U469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig="0.997002997002997" /xcortree=1874 /SigmaFactorBS="agcaaaaaccttcattctttcatgaatttaaagtattatata agcTACTGAAaaagttttgtataAAAGGTATAATGATAAAGAAcattcgttcttgtat g" /listShort="S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 655223..656506 /gene="bsuMA" /locus_tag="BSU_06060" /old_locus_tag="BSU06060" /EC_number="2.1.1.37" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11751814, 12682299, 16014871, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751814, 12682299, 16014871, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-methyltransferase (cytosine-specific); prophage 3 region" /protein_id="NP_388487.1" /db_xref="EnsemblGenomes-Gn:BSU06060" /db_xref="EnsemblGenomes-Tr:CAB12425" /db_xref="GOA:O34939" /db_xref="InterPro:IPR001525" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12787" /db_xref="UniProtKB/Swiss-Prot:O34939" /translation="MTNFILNENKQLSLAIEDENIENFYIDGTDLVRKIIRRSGSGVT SRVPVLSTQDLENKNLHELYDESWLRMKNRPNTELTTESINIADLFSGCGGLSLGVWE ACRALGINPRFSFACDLNEAALSVYEKNFSPDFSLNESIEKHINGELGAPLTVEEQRI KDKVKKIDFILAGPPCQGHSDLNNHTRRKDPRNALLMRVSRVIELFQPSSVLVENVPG IIHDKSGSFKEFKNHLKTQGYYFDEIVLNAEKLGVSQARRRYFIFASKTPVSSLNQIN EFYSTNSRPISWAISDLVENVGDDIFNTASEHSLENKRRIEYLFENNLFELPNSERPD CHRLKPHSYKSVYGRMYWDRPAPTITRGFGSTGQGRFVHSLLKRTITPHEAARIQFFP DFFNFGDLRRRQYQDVIGNAVPSKLSYLLALHQLR*" gene 655223..656506 /gene="bsuMA" /locus_tag="BSU_06060" /old_locus_tag="BSU06060" CDS 656528..657697 /gene="bsuMB" /locus_tag="BSU_06070" /old_locus_tag="BSU06070" /EC_number="2.1.1.37" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11751814, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751814, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-methyltransferase (cytosine-specific); defective prophage 3" /protein_id="NP_388488.1" /db_xref="EnsemblGenomes-Gn:BSU06070" /db_xref="EnsemblGenomes-Tr:CAB12426" /db_xref="GOA:O34680" /db_xref="InterPro:IPR001525" /db_xref="InterPro:IPR018117" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR031303" /db_xref="SubtiList:BG12788" /db_xref="UniProtKB/Swiss-Prot:O34680" /translation="MKVVSLFSGIGGIELGLHQSGHTTEIFCEVDPLAKAVLSKNFPG VKIEDDINEIRELPSCDLVAAGFPCQDLSQAGGKEGIDGSRSGLVKKLFELIEKKEHA NRPPWILIENVPYMLRLNRGKAMSYLTSVLSELGYTWAYRTVDARCFGLPQRRHRVIL LASLFEDPKDVIFSQDHSEPDLDGKPSVVDHSNYYGFYWTEGLRGVGWAREAVPPIKC GSSVGIASPPAVWSPYEDIVGTINIRDAERLQGFPEDWTNITTETGKDIKEGARWRLV GNAVSVRVSKWIGENLSQPKGSISDFEGELVTKTWPSAAWGYGDKKYKVPVSKWVANT EQIAISEFLNHPLKPLSARALNGFLGRAARCTNVNYSDEFINSLERCKDRQLQKV*" gene 656528..657697 /gene="bsuMB" /locus_tag="BSU_06070" /old_locus_tag="BSU06070" downshifts 657703 /Source="Nicolas_upshifts" /id="D293" /incds=0 /nref=237 /ntot=257 /MaxReadThrough="2.10319" /MaxDrop="7.17612" /score="34.7238204" /energy="-15.1" /TU="NA" /idTUdmin="U468" /TUdmin=0 /isTUend="TRUE" downshifts complement(657777) /Source="Nicolas_upshifts" /id="D294" /incds=0 /nref=26 /ntot=183 /MaxReadThrough="2.48582" /MaxDrop="4.12737" /score="11.0887998" /energy="-15.6" /TU="NA" /idTUdmin="U471" /TUdmin=2 /isTUend="TRUE" CDS complement(657793..658062) /gene="ydzWc" /locus_tag="BSU_06073" /old_locus_tag="BSU06073" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative phosphoglucomutase; C-terminal part of YdzW; defective prophage 3" /db_xref="PSEUDO:CAX52569.1" /translation="MNLASFGSVKVTTVEDYLTGIERLWKALRNSWAFHSQMFLNVFL KSDPWMCLRLSGTEPKIKFYFRVDESLAETRNPQRIEKEFMELVE*" gene complement(657793..658062) /gene="ydzWc" /locus_tag="BSU_06073" /old_locus_tag="BSU06073" /pseudo CDS complement(658019..658189) /gene="ydzWmc" /locus_tag="BSU_06074" /old_locus_tag="BSU06074" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative phosphoglucomutase; internal part of YdzW" /translation="MSLYEALLSIEEYGYFQEGLRSLTLKGKEGAELIQQTLAAFRSE FGQLWFRQGYHC*" gene complement(658019..658189) /gene="ydzWmc" /locus_tag="BSU_06074" /old_locus_tag="BSU06074" /pseudo CDS complement(658120..658605) /gene="ydzWmb" /locus_tag="BSU_06076" /old_locus_tag="BSU06076" /EC_number="5.4.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative phosphoglucomutase; internal part of YdzW" /translation="LIATDPDADRLGIAVKNENGEYTVLTGNQTEPLLLHYILTQIKK KGTLPSNGIVLKTIVTSELGREVATSFRVETIGVLTGFKFIARKINGYYKTGEHNFLF GYEESYGYLIGDFVRDKDAVQTDVLAVEVCAYYKKKGFHYTKLSLVLKNMATFRKACA H*" gene complement(658120..658605) /gene="ydzWmb" /locus_tag="BSU_06076" /old_locus_tag="BSU06076" /pseudo promotor_-35 658470..658473 /Source="Nicolas_upshift_promotors" /id="U470" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.997002997002997" /xcortree=3091 /SigmaFactorBS="aatcgttttaagaacgatcccattagatggaagtgttcCTTT cttttttatttgggTTAAGATATAGTGGAGCAGAagtggctcggtttgatttccggtt a" /listShort="S214" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 658488..658507 /Source="Nicolas_upshift_promotors" /id="U470" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.997002997002997" /xcortree=3091 /SigmaFactorBS="aatcgttttaagaacgatcccattagatggaagtgttcCTTT cttttttatttgggTTAAGATATAGTGGAGCAGAagtggctcggtttgatttccggtt a" /listShort="S214" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 658492 /Source="Nicolas_upshifts" /id="U470" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.997002997002997" /xcortree=3091 /SigmaFactorBS="aatcgttttaagaacgatcccattagatggaagtgttcCTTT cttttttatttgggTTAAGATATAGTGGAGCAGAagtggctcggtttgatttccggtt a" /listShort="S214" /GFF_Attribute="listLong" S_feature 658495..658899 /Source="Nicolas_S_feature" /locus_tag="new_658495_658899" /HighExp="Cold, LoTm, C30, T0.30H, HPh, Gly, S0, LPh, UNK1, T1.0H" /AntisenseName="ydzW" /AntisenseCor="0.298083403528066" /AntisenseRegPval="-6.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S214" CDS complement(658615..658758) /gene="ydzW" /locus_tag="BSU_06077" /old_locus_tag="BSU06077" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative phosphomannomutase; internal part of YdzW" /db_xref="PSEUDO:CAX52572.1" /translation="MALAAMNYKHVAVGKEQEQPALCFPLSPVQMLKNMPRLSWPSGK AAN*" gene complement(658615..658758) /gene="ydzW" /locus_tag="BSU_06077" /old_locus_tag="BSU06077" /pseudo CDS complement(658813..659010) /gene="ydzW" /locus_tag="BSU_06078" /old_locus_tag="BSU06078" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative phosphoglucomutase; internal part of YdzW" /translation="FAVRHLHGFAGIVVTASHNPPEYNGYKVYGPDGGQLPPSKGPDQ NIAQRWTRHTLNYFRKLKYLR*" gene complement(658813..659010) /gene="ydzW" /locus_tag="BSU_06078" /old_locus_tag="BSU06078" /pseudo CDS complement(658968..659129) /gene="ydzWma" /locus_tag="BSU_06079" /old_locus_tag="BSU06079" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative phosphomannomutase; internal part of YdzW" /translation="DIYTLRKVSAGLAAFIMEAARTLASSAYVFESLRPTTVLSLQYV TFMVLPVLL*" gene complement(658968..659129) /gene="ydzWma" /locus_tag="BSU_06079" /old_locus_tag="BSU06079" /pseudo CDS complement(659114..659221) /gene="ydzWn" /locus_tag="BSU_06083" /old_locus_tag="BSU06083" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative phosphomannomutase; N-terminal part of YdzW; defective prophage 3" /translation="MRKTWKMLFIRNLGYGTGGMRGEIGAGTNRMTSIR*" gene complement(659114..659221) /gene="ydzWn" /locus_tag="BSU_06083" /old_locus_tag="BSU06083" /pseudo S_feature complement(659222..659341) /Source="Nicolas_S_feature" /locus_tag="new_659222_659341_c" /HighExp="LoTm, T4.0H, BC, T5.0H, M9-stat, T3.30H, S2, T3.0H, Sw, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 0.977" /TUlongSig="NA" /TUlongPSig="NA" /label="S215" promotor_-10 complement(659332..659351) /Source="Nicolas_upshift_promotors" /id="U471" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.321678321678322" /psig="0.993006993006993" /xcortree=2932 /SigmaFactorBS="caagagcactcgatttatgtcagaaagtcgtCGTTcgaaaac ctctagacTATATTATAATGAACAATAAtgttattttattgtaggtcaatcataggct g" /listShort="S215, ydzW, ydzW, ydzW, ydzW, ydzW, ydzW, ydzW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(659341) /Source="Nicolas_upshifts" /id="U471" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.321678321678322" /psig="0.993006993006993" /xcortree=2932 /SigmaFactorBS="caagagcactcgatttatgtcagaaagtcgtCGTTcgaaaac ctctagacTATATTATAATGAACAATAAtgttattttattgtaggtcaatcataggct g" /listShort="S215, ydzW, ydzW, ydzW, ydzW, ydzW, ydzW, ydzW" /GFF_Attribute="listLong" S_feature complement(659343..659558) /Source="Nicolas_S_feature" /locus_tag="new_659343_659558_c" /HighExp="LBGstat, T0.30H, M9-stat, T1.0H, T1.30H, Lbtran, T2.0H, LBGtran, T2.30H, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.11296" /TUshortSig="SigA" /TUshortPSig="0.977" /TUlongSig="NA" /TUlongPSig="NA" /label="S216" promotor_-35 complement(659367..659370) /Source="Nicolas_upshift_promotors" /id="U471" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.321678321678322" /psig="0.993006993006993" /xcortree=2932 /SigmaFactorBS="caagagcactcgatttatgtcagaaagtcgtCGTTcgaaaac ctctagacTATATTATAATGAACAATAAtgttattttattgtaggtcaatcataggct g" /listShort="S215, ydzW, ydzW, ydzW, ydzW, ydzW, ydzW, ydzW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 659535..659541 /Source="Nicolas_upshift_promotors" /id="U473" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig=1 /xcortree=2344 /SigmaFactorBS="taccaattcgatatttgaattggtctctcaaacaaTTCCATC ctctttatttatTATGATACAATTATATTAATtagaaaatacatacatattagcttgt g" /listShort="ydiR, ydiS, ydjA, S217, S218, ydjB, S219, ydjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(659544..659563) /Source="Nicolas_upshift_promotors" /id="U472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.458541458541459" /psig="0.977022977022977" /xcortree=3186 /SigmaFactorBS="tttacccccataaaatcacacaagctaatatgtatgtATTTt ctaattaatataaTTGTATCATAATAAATAAAGaggatggaattgtttgagagaccaa t" /listShort="S216, S215, ydzW, ydzW, ydzW, ydzW, ydzW, ydzW" /listLong="ydzW" /label="promotor_-10" promotor_-10 659554..659573 /Source="Nicolas_upshift_promotors" /id="U473" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig=1 /xcortree=2344 /SigmaFactorBS="taccaattcgatatttgaattggtctctcaaacaaTTCCATC ctctttatttatTATGATACAATTATATTAATtagaaaatacatacatattagcttgt g" /listShort="ydiR, ydiS, ydjA, S217, S218, ydjB, S219, ydjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(659558) /Source="Nicolas_upshifts" /id="U472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.458541458541459" /psig="0.977022977022977" /xcortree=3186 /SigmaFactorBS="tttacccccataaaatcacacaagctaatatgtatgtATTTt ctaattaatataaTTGTATCATAATAAATAAAGaggatggaattgtttgagagaccaa t" /listShort="S216, S215, ydzW, ydzW, ydzW, ydzW, ydzW, ydzW" /listLong="ydzW" upshifts 659560 /Source="Nicolas_upshifts" /id="U473" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig=1 /xcortree=2344 /SigmaFactorBS="taccaattcgatatttgaattggtctctcaaacaaTTCCATC ctctttatttatTATGATACAATTATATTAATtagaaaatacatacatattagcttgt g" /listShort="ydiR, ydiS, ydjA, S217, S218, ydjB, S219, ydjC" /GFF_Attribute="listLong" promotor_-35 complement(659578..659581) /Source="Nicolas_upshift_promotors" /id="U472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.458541458541459" /psig="0.977022977022977" /xcortree=3186 /SigmaFactorBS="tttacccccataaaatcacacaagctaatatgtatgtATTTt ctaattaatataaTTGTATCATAATAAATAAAGaggatggaattgtttgagagaccaa t" /listShort="S216, S215, ydzW, ydzW, ydzW, ydzW, ydzW, ydzW" /listLong="ydzW" /label="promotor_-35" CDS 659623..660564 /gene="bsuRA" /locus_tag="BSU_06090" /old_locus_tag="BSU06090" /EC_number="3.1.21.4" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11751814, 15728999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751814, 15728999; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type-2 restriction enzyme BsuMI component BsuRA (YdiR); prophage region 3" /protein_id="NP_388490.1" /db_xref="EnsemblGenomes-Gn:BSU06090" /db_xref="EnsemblGenomes-Tr:CAB12428" /db_xref="GOA:O35025" /db_xref="SubtiList:BG12790" /db_xref="UniProtKB/Swiss-Prot:O35025" /translation="MTFIKRLEDAYETLLGNYPAGVSSTSTSKYNEIRKIVSEAFLIG ENEVYVTGTSRRISNLDTRFAQGNQRNKHTRMAVAFISIPSVDDSELDELIIRTRNSA ITTSSKFCNGEERGTIFDGILLFLVFEGETKVYPLAFLVFENDFELKEKAEELIPGIE LKEYPRANQSPAQENNKSAKNEDEESAKSYVVFLDIEEDGSIVEFVEDKDKTYRIGDM IWTASHTNGSSAITRRLEVIEVVENLVVCKIKHKYNEPVDKNSLLKFVNIEQDLISFL DLHPNVQNGSEGFVSGDIVDENATTSSDDLPEDFENN*" gene 659623..660564 /gene="bsuRA" /locus_tag="BSU_06090" /old_locus_tag="BSU06090" CDS 660596..661627 /gene="bsuRB" /locus_tag="BSU_06100" /old_locus_tag="BSU06100" /EC_number="3.1.21.4" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11751814" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type-2 restriction enzyme BsuMI component BsuRB (YdiS); prophage region 3" /protein_id="NP_388491.1" /db_xref="EnsemblGenomes-Gn:BSU06100" /db_xref="EnsemblGenomes-Tr:CAB12429" /db_xref="GOA:O34885" /db_xref="InterPro:IPR011704" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12791" /db_xref="UniProtKB/Swiss-Prot:O34885" /translation="MEISKQTSDLLLSLEKKKGTLPKFSVLRSIPRNRIIYGAPGTGK SNYLEREVGKIFGDNPYVFTRVTFFPGYTYGQFIGAYKPVPIYKKLSGEEEIFSSNFR DKMENFEPMIDYQFVPGPFIDVLIKALKNRYTNFILIIEEINRANAASVFGDIFQLLD RNKNGESDYPVTFGPDIMNYLARNGIKDEMIKLPSNFFIWATMNNADQGVLPLDTAFK RRWSFEYLELEKYRKAVDSWKLSLRYKGHNKVIMWNDFRDIINKRLKGKVPEDKLLGP FFLKESELWNQNVFKNKLLYYLKEDVFKHNPTIDFLNASTFSELIEKYDGSDNIFTFD IDDSSFVSD*" gene 660596..661627 /gene="bsuRB" /locus_tag="BSU_06100" /old_locus_tag="BSU06100" CDS 661630..663027 /gene="bsuRC" /locus_tag="BSU_06110" /old_locus_tag="BSU06110" /EC_number="3.1.21.4" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11751814" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type-2 restriction enzyme BsuMI component BsuRC (YdjA); prophage region 3" /protein_id="NP_388492.1" /db_xref="EnsemblGenomes-Gn:BSU06110" /db_xref="EnsemblGenomes-Tr:CAB12430" /db_xref="GOA:O34303" /db_xref="InterPro:IPR018579" /db_xref="SubtiList:BG12792" /db_xref="UniProtKB/Swiss-Prot:O34303" /translation="MDKSSKFFFEDQKYNKERIVRVLGGNLALLKSKGILYEDSSGDL IFNYVGVISNGRNVIFILPKYCNRHLDEHSKRTLFNKLLKIFKKYSGLNKSRESDYFV SELDSDEVSDFMIADYLLNDFSLNGYYQKKFTEYEIDGEGIIDWSKTVNEITPVFSKG VPYYFSTYNEVVQKDEYHLIVKIHKWALSKYFNDFGVILGFTGLEFDKSCDGMKILDY ADFFGSVINKEIVNTYVDRDVKLLKALKTAIDREENQFSKRPTLSLYGTKYFHRVWEE VCKTVFSHVNEYVKKISRPNWINFTDIEVNKEKKTLEPDIIKAFEYRSKEYFLILDAK YYNINFDGKKLEGNPGVEDITKQLLYDKALEKLSRGKTKHNAFLFPSSNSTNTFKVFG SVDFDFLDIAAVTLVYISAEQVYNLYLENKTFSTDDLFKFVSEINKSKKRHSVITSTL YGNMFLFTKRLSDKN*" gene 661630..663027 /gene="bsuRC" /locus_tag="BSU_06110" /old_locus_tag="BSU06110" S_feature 663028..663224 /Source="Nicolas_S_feature" /locus_tag="new_663028_663224" /HighExp="Lbtran, C90, M40t45, HPh, M0t45, LBGtran, aero, Lbstat, BI, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S217" downshifts 663181 /Source="Nicolas_upshifts" /id="D295" /incds=0 /nref=3 /ntot=131 /MaxReadThrough="5.36465" /MaxDrop="3.0162" /score="7.16368756" /energy="-18.1" /TU="U473" /idTUdmin="U473" /TUdmin="-1364" /isTUend="FALSE" downshifts 663243 /Source="Nicolas_upshifts" /id="D296" /incds=0 /nref=5 /ntot=69 /MaxReadThrough="4.58628" /MaxDrop="3.49698" /score="7.16368756" /energy="-18.1" /TU="U473" /idTUdmin="U473" /TUdmin="-1302" /isTUend="FALSE" S_feature 663288..663600 /Source="Nicolas_S_feature" /locus_tag="new_663288_663600" /HighExp="dia15, Diami, H2O2, Paraq, dia5, LBGstat, G180, Oxctl, LBGexp, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S218" CDS 663601..663936 /gene="ydjB" /locus_tag="BSU_06120" /old_locus_tag="BSU06120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein; prophage region 3" /protein_id="NP_388493.1" /db_xref="EnsemblGenomes-Gn:BSU06120" /db_xref="EnsemblGenomes-Tr:CAB12431" /db_xref="SubtiList:BG12793" /db_xref="UniProtKB/Swiss-Prot:O34778" /translation="MLNIKSDRIMTSDPQKFTVDGVRFFQQYLNKIRPDAMEIDNLII NSDIIKEDLIVHVSKMIDRLALYDLHRKRSIDKHFSAAFTVDINDREEFYSANIADVS IDLNESSGV*" gene 663601..663936 /gene="ydjB" /locus_tag="BSU_06120" /old_locus_tag="BSU06120" S_feature 663937..664318 /Source="Nicolas_S_feature" /locus_tag="new_663937_664318" /HighExp="H2O2, dia15, G135, Paraq, G180, G150, Diami, Oxctl, LBGexp, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S219" CDS 664319..664669 /gene="ydjC" /locus_tag="BSU_06130" /old_locus_tag="BSU06130" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; prophage region 3" /protein_id="NP_388494.1" /db_xref="EnsemblGenomes-Gn:BSU06130" /db_xref="EnsemblGenomes-Tr:CAB12432" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12794" /db_xref="UniProtKB/Swiss-Prot:O34715" /translation="MVSIFYANRLSYSIWNTIPGKYIREELEQNGVTYNELIKYWDIT DPSQALPKVNKDNVLLISAKHDQYIDLKDADYLWESWGRPTRYVYNCGHSGIVLCRKK LANDTLSFIREKLV*" gene 664319..664669 /gene="ydjC" /locus_tag="BSU_06130" /old_locus_tag="BSU06130" downshifts 664545 /Source="Nicolas_upshifts" /id="D297" /incds=1 /nref=1 /ntot=71 /MaxReadThrough="1.89703" /MaxDrop="2.58458" /score="-4.72838456" /energy="-13.9" /TU="NA" /idTUdmin="U473" /TUdmin=0 /isTUend="TRUE" CDS complement(664775..667264) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11118449, 11390381, 12897001" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11118449, 11390381, 12897001; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the glucitol operon" /protein_id="NP_388495.1" /db_xref="EnsemblGenomes-Gn:BSU06140" /db_xref="EnsemblGenomes-Tr:CAB12433" /db_xref="GOA:P39143" /db_xref="InterPro:IPR002182" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR024123" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10178" /db_xref="UniProtKB/Swiss-Prot:P39143" /translation="MAELENRKQFAQMLAPGVKTLKLHPDYKVRRKKNEKTGQSYIDK IALQLGVSPNTIKSWIGQMGANYIPGRIDDGKLFGMIWIILEKTDLDIEWLTDLLEAT TIPVIKPALPVWAASCLKKAKILRKDGLFGAPSEGEIENVVKRLFHDRPGQETNALTE QPITHNLPSRWSGRFIGRSFDMEAIRQWMLSPSPVCLITGWAGMGKTTIALEAAYSCV DDTSVWPAFNSIIWVSADWKGLSFSDFLNTIAYQLGRKEQIDKSINVKRFVVRNALAN YTREKPILLIVDSIDTAERDIHEFITSLPQGVKVLLTARENVKQTYRESFGEMTAIQL SGLDQTDAHEFFQQEVHHCLQTCNLPRKREKLEQLLHLSSDLKNEFISATAGNPKAMA LSIAYMSDDDIPAQQLIHELGKAGYSLLELFEFLFGRTWDRCNEDTRKLWQTLCFFSK PPDEKSLAAAAGLDARRFHYAMEQMRSYALIQPERSQGRTQYLAHQTVVAYGEQHLSE QHEYEKEARNRWAHYYIDYAETHLKREQPNSIYWSYLLGRNLDQMKQEWPNILKVIQW ASETEQKEILIELITRISHFLSRINLPLRIEYGRKAADAAHHLGQHTREAYFRIDTSG WALMEVNDLDGALQQIEAGLKILEQSDAHDAYDLKVWGHALKARLFLKDGQQEKAETI LNEIENQPISPTIQHRVLLVRGDLSFARGYHVEAIQLYEAANEISSTYGGEKTIEAYF NLGVAYVKCDQFEKAEEAFEQMLYDKHNANQVELIYYHYGMAQLLYRKGEKTKAVESN QKAIRLIDSWEPAIGIRGEVERLARATKENE*" gene complement(664775..667264) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" downshifts complement(664797) /Source="Nicolas_upshifts" /id="D298" /incds=0 /nref=56 /ntot=209 /MaxReadThrough="0.69715" /MaxDrop="4.256" /score="0.285109352" /energy="-13.9" /TU="NA" /idTUdmin="U474" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(667278..667297) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(667304) /Source="Nicolas_upshifts" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" promotor_-35 complement(667311..667318) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 667367..667368 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 667383..667465 /Source="Nicolas_S_feature" /locus_tag="new_667383_667465" /HighExp="Lbstat, BI, M40t90, Mt0, M0t90, dia5, dia0, Lbexp, Lbtran, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.848" /TUlongSig="NA" /TUlongPSig="NA" /label="S220" upshifts 667383 /Source="Nicolas_upshifts" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" promotor_-10 667384..667403 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 667466..668527 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" /EC_number="1.1.1.14" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1460002, 8195086, 8195087, 12897001, 19784641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1460002, 8195086, 8195087, 12897001, 19784641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucitol (sorbitol) dehydrogenase" /protein_id="NP_388496.1" /db_xref="EnsemblGenomes-Gn:BSU06150" /db_xref="EnsemblGenomes-Tr:CAB12434" /db_xref="GOA:Q06004" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10177" /db_xref="UniProtKB/Swiss-Prot:Q06004" /translation="MTHTVPQNMKAAVMHNTREIKIETLPVPDINHDEVLIKVMAVGI CGSDLHYYTNGRIGNYVVEKPFILGHECAGEIAAVGSSVDQFKVGDRVAVEPGVTCGR CEACKEGRYNLCPDVQFLATPPVDGAFVQYIKMRQDFVFLIPDSLSYEEAALIEPFSV GIHAAARTKLQPGSTIAIMGMGPVGLMAVAAAKAFGAGTIIVTDLEPLRLEAAKKMGA THIINIREQDALEEIKTITNDRGVDVAWETAGNPAALQSALASVRRGGKLAIVGLPSQ NEIPLNVPFIADNEIDIYGIFRYANTYPKGIEFLASGIVDTKHLVTDQYSLEQTQDAM ERALQFKNECLKVMVYPNR*" gene 667466..668527 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" CDS 668601..669992 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897001, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+-glucitol symporter; prophage region 3" /protein_id="NP_388497.1" /db_xref="EnsemblGenomes-Gn:BSU06160" /db_xref="EnsemblGenomes-Tr:CAB12435" /db_xref="GOA:O34368" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12795" /db_xref="UniProtKB/Swiss-Prot:O34368" /translation="MIGTEKVTALKAKHQSKSSTGLSWFERIGYGFGDMSYNIIFQFV NAYLLFYYTDVGGIQPAVIATLFLVVRVLDAIFDPIMGLILDKTNTRWGKARPYLLWV AFPFALFTFLCFTTPHFGETGNMVYAYVTYILLGMSFSMQTIPVNSLTGRMTNSVEER TVLTTTRMILVYIGILLSISCATPLATAIGGEDQAFGFQMTALIYAAVSIVLNLFSFF TVRERIQPKKRKKQGIKKTLSVLFKNKPLLMLISSFLAFAIGFNIKLSTMVYYFTYNV NHKEFVFMGTVLFFGAALISNLFIPFFSEKWGRKQVMIITAALSLISYAGLHFTPYSS IPLIFIWLFASGFFTTPLNTLAWGMVADCVDYAEWKTGIRADGVVISSMSFINKLGVA LAGSFSAIYLGIAGYVANTDQTVASLNAIKNMNALIPGFFILLSIILIAFYPLTEKRY KHIISELEQRSAR*" gene 668601..669992 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" promotor_-35 670019..670026 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 670040..670059 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 670045 /Source="Nicolas_upshifts" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" CDS 670087..671049 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26483775, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar kinase (ribokinase family); prophage region 3" /protein_id="NP_388498.1" /db_xref="EnsemblGenomes-Gn:BSU06170" /db_xref="EnsemblGenomes-Tr:CAB12436" /db_xref="GOA:O34768" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12796" /db_xref="UniProtKB/Swiss-Prot:O34768" /translation="MRSHSVVCIGELLIDFFCTDVDVDLMEGRQFLKSAGGAPANVSA AIAKLGGDAAFSGKVGKDPFGYFLKRTLDAVHVDTSMLVMDEKAPTTLAFVSLKQNGE RDFVFNRGADALFTLEDIDQEKLNEAKILHFGSATALLSDPFCSAYLRLMSIAKDNGQ FISFDPNYREDLWRGRVSEFVSVAKKAIAVSDFVKVSDEELEIISGVKDHEKGVAILH EIGANIVAVTLGKSGTLLSNGKDREIIPSIPVTSIDSTGAGDAFVGAALYQLANTDQI QSVDADFVKLREIVAFANKVGALVCTKIGAIDALPSLDEIGVSL*" gene 670087..671049 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" downshifts 671034 /Source="Nicolas_upshifts" /id="D299" /incds=0 /nref=86 /ntot=213 /MaxReadThrough="2.99546" /MaxDrop="4.52045" /score="16.4550614" /energy="-14" /TU="NA" /idTUdmin="U475" /TUdmin="-1" /isTUend="TRUE" promotor_-35 671174..671183 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 671190 /Source="Nicolas_upshifts" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" promotor_-10 671196..671211 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 671245..671928 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11454200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11454200; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage shock protein A homolog regulator; prophage region 3" /protein_id="NP_388499.1" /db_xref="EnsemblGenomes-Gn:BSU06180" /db_xref="EnsemblGenomes-Tr:CAB12437" /db_xref="GOA:P54617" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG12797" /db_xref="UniProtKB/Swiss-Prot:P54617" /translation="MSIIGRFKDIMSANINALLDKAENPEKMVDQYLRNMNSDLAKVK AETAAVMAEEQRAKREYHECQADMEKMESYAMKALQAGNESDARKFLERKTSLESKLS ELQAANQIAATNAAQMRKMHDKLVSDIGELEARKNMIKAKWAVAKTQERMNKLGASVS STSQSMSAFGRMEDKVNKALDQANAMAELNSAPQDDMADLSAKYDTGGSSQVDDELAA LKAKMMLDK*" gene 671245..671928 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" S_feature 671929..671993 /Source="Nicolas_S_feature" /locus_tag="new_671929_671993" /HighExp="Salt, S0, aero, T-0.40H, T-1.40H, SMMPr, T-1.10H, T0.0H, Cold, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S221" CDS 671994..673019 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" /function="16.5: Explore" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage replication protein; prophage region 3" /protein_id="NP_388500.1" /db_xref="EnsemblGenomes-Gn:BSU06190" /db_xref="EnsemblGenomes-Tr:CAB12438" /db_xref="GOA:O34434" /db_xref="InterPro:IPR013137" /db_xref="SubtiList:BG12798" /db_xref="UniProtKB/Swiss-Prot:O34434" /translation="MIISYKCPNCGSDMAFDSETGSLSCSSCGRQDNIESLPKENIAA RFSDDEAKEYQCKNCGAVLITEAETTATTCSFCGGAAILADRLSGHLAPAKVIPFTIS KQEAEQAFRKWCKKGLLTPRGFMSADRIKSITGMYIPFWMFDLNSEVQVRANCTRVHQ YEEGDYICTETEHFEAFRDINLDYLKIPVDASEKMKDELMDKLEPYSYEELKDFQTAY LAGYIAEKYNYTDEELFPRAKEKISSYIDSYIHSTFSGYTSVNVRDKHIHTKNVNSFY VLLPVWMVSYDYERAEHIFAMNGQTGKVVGKPPISRGKVAAWFSGIAGGTFLALKLVS LMMGGGF*" gene 671994..673019 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" CDS 673019..673783 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; prophage region 3" /protein_id="NP_388501.1" /db_xref="EnsemblGenomes-Gn:BSU06200" /db_xref="EnsemblGenomes-Tr:CAB12439" /db_xref="GOA:O35004" /db_xref="InterPro:IPR007621" /db_xref="SubtiList:BG12799" /db_xref="UniProtKB/Swiss-Prot:O35004" /translation="MRGFFGKAIFVVLAVFIMMPLLGIEAVRASELQQHVYDRAHLLS KAEIGKLESLSAKLGAKRDTDFIIITTKSTNGEDIADYTGDFYDRYGKGSTAILTIDM TNREVFIAGFKKAEQYLDNSRLNSIRNTISSDLSNENYFEAFETYIQLSYKDMGIKPG VNPDNIFFTWWFQLIAAIAVGGIAVSIMLYHAGGKVTVNGSTYMDQRTSDVIDQYDTY IRTTVTRERKPSDKDSGSDGGVTKGGTSYSGSRGSF*" gene 673019..673783 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" CDS 673814..674785 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388502.1" /db_xref="EnsemblGenomes-Gn:BSU06210" /db_xref="EnsemblGenomes-Tr:CAB12440" /db_xref="InterPro:IPR033880" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG12800" /db_xref="UniProtKB/Swiss-Prot:O34789" /translation="MSFFRNQLANVVEWEEFRDDMIFYKWNNREIKKGSRLIIRPGQD AVFLNNGRVEGVFQDDGDYDIESEIIPFLSTLKGFKFGFNSGMRAEVLFVNTKEFTVR WGTKQAINIPAAGMPGGMPIRANGTFNFKVQDYISLIDKIAGVKDQYFVEDIKTRIIS ILDQLLMKWITREGKDMFNLQANAFDIAKGIQEDLDMQLISDGMTVTGFQIMSFNYPQ EVQDMITKNASYGMVGDVNRYQQISMTDGMASGKMSGSGAASDMAGMMMGMNMANQMM NQMNQNQQAQSSGPQSTGSGSKPNFCPNCGTKTGEANFCPNCGQKLV*" gene 673814..674785 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" downshifts 674775 /Source="Nicolas_upshifts" /id="D300" /incds=0 /nref=180 /ntot=247 /MaxReadThrough="2.71622" /MaxDrop="5.81579" /score="16.72046" /energy="-11.1" /TU="U477" /idTUdmin="U477" /TUdmin="-44" /isTUend="FALSE" downshifts 674819 /Source="Nicolas_upshifts" /id="D301" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="2.13813" /MaxDrop="3.25329" /score="16.72046" /energy="-11.1" /TU="NA" /idTUdmin="U477" /TUdmin=0 /isTUend="TRUE" CDS complement(674832..675857) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane associated potassium channel; prophage region 3" /protein_id="NP_388503.1" /db_xref="EnsemblGenomes-Gn:BSU06220" /db_xref="EnsemblGenomes-Tr:CAB12441" /db_xref="GOA:O34733" /db_xref="InterPro:IPR013099" /db_xref="SubtiList:BG12801" /db_xref="UniProtKB/Swiss-Prot:O34733" /translation="MNEGYIIAGLLLLTAGMIDFLWTTLWLESGAGPITRCLSAWLWK GCRKISGDHAKVLSMAGPLLLCLTLVIWISLFWSGWVLIYSSDPHSLMETQSKEPASW SDRIYFSGYVMFTLGNGDLAPNGGLWKLVTIIETAQGLLTITFSVTYLISVLSAVNQK RSFAQSVLSLGHDGTEIVHNAWNGKDFHDIDFLLVAASSELGKLTAQHNAFPILHFYH STQHQESSIIAVAVLDEALTIFKYGIPEQYQPNQLHIKEARSSIKNYLDTVHTAYIHP AEQAPPEPDISKLQQSGIPALSKQTFQIAVNSIKERRQLLLGIIQAGARKWPVQEQAI GNAYSPK*" gene complement(674832..675857) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" promotor_-10 complement(675889..675908) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(675907) /Source="Nicolas_upshifts" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" promotor_-35 complement(675922..675928) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 676117..676124 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 676137 /Source="Nicolas_upshifts" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" S_feature 676139..676441 /Source="Nicolas_S_feature" /locus_tag="new_676139_676441" /HighExp="M0t90, M40t90, Lbtran, T0.30H, BI, T1.0H, M9-stat, S1, T1.30H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.28450700000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S222" promotor_-10 676139..676158 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 676442..677863 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11807058, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807058, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="myo-inositol transporter" /protein_id="NP_388504.1" /db_xref="EnsemblGenomes-Gn:BSU06230" /db_xref="EnsemblGenomes-Tr:CAB12442" /db_xref="GOA:O34718" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12802" /db_xref="UniProtKB/Swiss-Prot:O34718" /translation="MNKQGNQMSFLRTIILVSTFGGLLFGYDTGVLNGALPYMGEPDQ LNLNAFTEGLVTSSLLFGAALGAVFGGRMSDFNGRRKNILFLAVIFFISTIGCTFAPN VTVMIISRFVLGIAVGGASVTVPAYLAEMSPVESRGRMVTQNELMIVSGQLLAFVFNA ILGTTMGDNSHVWRFMLVIASLPALFLFFGMIRMPESPRWLVSKGRKEDALRVLKKIR DEKRAAAELQEIEFAFKKEDQLEKATFKDLSVPWVRRIVFIGLGIAIVQQITGVNSIM YYGTEILRNSGFQTEAALIGNIANGVISVLATFVGIWLLGRVGRRPMLMTGLIGTTTA LLLIGIFSLVLEGSPALPYVVLSLTVTFLAFQQGAISPVTWLMLSEIFPLRLRGLGMG VTVFCLWMVNFAVSFTFPILLAAIGLSTTFFIFVGLGICSVLFVKRFLPETKGLSLEQ LEENFRAYDHSGAKKDSGAEVIG*" gene 676442..677863 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" downshifts 677855 /Source="Nicolas_upshifts" /id="D302" /incds=0 /nref=11 /ntot=24 /MaxReadThrough="2.82455" /MaxDrop="8.02371" /score="11.3880907" /energy="-11.2" /TU="NA" /idTUdmin="U479" /TUdmin=0 /isTUend="TRUE" downshifts complement(677911) /Source="Nicolas_upshifts" /id="D303" /incds=0 /nref=242 /ntot=272 /MaxReadThrough="1.00274" /MaxDrop="9.32541" /score="13.6781112" /energy="-11.2" /TU="NA" /idTUdmin="U482" /TUdmin="-2" /isTUend="TRUE" CDS complement(677911..678951) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" /EC_number="1.1.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12469342, 18820069, 24525333, 26428232, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12469342, 18820069, 24525333, 26428232, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin reductase/2,3-butanediol dehydrogenase" /protein_id="NP_388505.1" /db_xref="EnsemblGenomes-Gn:BSU06240" /db_xref="EnsemblGenomes-Tr:CAB12443" /db_xref="GOA:O34788" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12803" /db_xref="UniProtKB/Swiss-Prot:O34788" /translation="MKAARWHNQKDIRIEHIEEPKTEPGKVKIKVKWCGICGSDLHEY LGGPIFIPVDKPHPLTNETAPVTMGHEFSGEVVEVGEGVENYKVGDRVVVEPIFATHG HQGAYNLDEQMGFLGLAGGGGGFSEYVSVDEELLFKLPDELSYEQGALVEPSAVALYA VRSSKLKAGDKAAVFGCGPIGLLVIEALKAAGATDIYAVELSPERQQKAEELGAIIVD PSKTDDVVAEIAERTGGGVDVAFEVTGVPVVLRQAIQSTTIAGETVIVSIWEKGAEIH PNDIVIKERTVKGIIGYRDIFPAVLSLMKEGYFSADKLVTKKIVLDDLIEEGFGALIK EKSQVKILVRPN*" gene complement(677911..678951) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" promotor_-35 678491..678500 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 678514..678533 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 678515..679050 /Source="Nicolas_S_feature" /locus_tag="new_678515_679050" /HighExp="C30, Gly, S6, C90, S8, BT, S7, Sw, Fru, Lbstat" /AntisenseName="bdhA" /AntisenseCor="-0.174163895138467" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S223" upshifts 678515 /Source="Nicolas_upshifts" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" S_feature complement(678952..679246) /Source="Nicolas_S_feature" /locus_tag="new_678952_679246_c" /HighExp="Lbtran, BI, T1.0H, M40t90, LBGstat, LoTm, T0.30H, LPhT, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S224" misc_feature 679051..679070 /Source="Nicolas_upshift_promotors" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 679052..679349 /Source="Nicolas_S_feature" /locus_tag="new_679052_679349" /HighExp="G180, Paraq, Oxctl, H2O2, G135, G150, MG 5, C30, UNK1, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S225" upshifts 679052 /Source="Nicolas_upshifts" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" misc_feature complement(679241..679255) /Source="Nicolas_upshift_promotors" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(679246) /Source="Nicolas_upshifts" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" promotor_-35 679329 /Source="Nicolas_upshift_promotors" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 679348..679367 /Source="Nicolas_upshift_promotors" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 679351 /Source="Nicolas_upshifts" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" CDS 679390..679761 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" /experiment="publication(s) with functional evidences, PMID:17581128, 20487291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17581128, 20487291; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein involved in cell wall metabolism" /protein_id="NP_388506.1" /db_xref="EnsemblGenomes-Gn:BSU06250" /db_xref="EnsemblGenomes-Tr:CAB12444" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG11036" /db_xref="UniProtKB/Swiss-Prot:P40775" /translation="MLKKVILAAFILVGSTLGAFSFSSDASAKHVNGNITWYNGVGKK GSSGKKLGHWDCATKIGFDVPRNGTKIRAYAKAKPKKVITVYKNDVGRMPNAVLDVSP KAFKALGYPLSKGKVAGHYSY*" gene 679390..679761 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" downshifts 679747 /Source="Nicolas_upshifts" /id="D304" /incds=0 /nref=5 /ntot=52 /MaxReadThrough="5.74148" /MaxDrop="2.8439" /score="-1.55787542" /energy="-7.4" /TU="U483" /idTUdmin="U481" /TUdmin=418 /isTUend="FALSE" CDS 679827..680873 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388507.1" /db_xref="EnsemblGenomes-Gn:BSU06260" /db_xref="EnsemblGenomes-Tr:CAB12445" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12804" /db_xref="UniProtKB/Swiss-Prot:O34353" /translation="MKKRIILLLAVIIAAAAAGVAFYVAKDKGHEKAADVSVNTESGD ELLVSITDTDLLTKYYENDKVIHEEKLTSYPAFALDQKQQVLYYTGNNEQNEMRLFKL DLKSHKKTMLYKGAESADSLFLSKDRSTIYFRLGKADESNFRIAAFDLKTKKYKNLYP AANDQDDTVSSFFYNQKNDSFALLHYSVEEDYKKTDEANEKGIDPEPTTIHFAEGRQN KFNELKSLNQFISDIAVSDDDKRILFTSYTQKGTEQTASIQMLNADTKKYESIISNQK SFKLLIDAQPQFSKDGKNIYFLAEAKGAKKLKDETGREAKVRTIYSYSLENKTFKKVW ENPNGIINSFFVIN*" gene 679827..680873 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" downshifts 680847 /Source="Nicolas_upshifts" /id="D305" /incds=0 /nref=41 /ntot=177 /MaxReadThrough="1.73572" /MaxDrop="4.49184" /score="21.8200083" /energy="-13.9" /TU="NA" /idTUdmin="U483" /TUdmin=0 /isTUend="TRUE" CDS complement(680907..681065) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097689.1" /db_xref="EnsemblGenomes-Gn:BSU06269" /db_xref="EnsemblGenomes-Tr:CAX52576" /db_xref="GOA:O24817" /db_xref="UniProtKB/Swiss-Prot:O24817" /translation="MISNQQQKDLKKRAAFKKLNVAMNSYVELLFLSVPLIHIFKWLG SLALHLIH*" gene complement(680907..681065) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" downshifts complement(680923) /Source="Nicolas_upshifts" /id="D306" /incds=0 /nref=23 /ntot=155 /MaxReadThrough="0.7906" /MaxDrop="3.61386" /score="9.10659473" /energy="-10.1" /TU="NA" /idTUdmin="U487" /TUdmin=0 /isTUend="TRUE" S_feature complement(681122..681254) /Source="Nicolas_S_feature" /locus_tag="new_681122_681254_c" /HighExp="LoTm, S8, S5, S6, S4, B36, S7, Cold, B60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigWXY" /TUshortPSig="0.994, 1, 1" /TUlongSig="SigK" /TUlongPSig="0.994" /label="S226" downshifts complement(681165) /Source="Nicolas_upshifts" /id="D307" /incds=0 /nref=57 /ntot=272 /MaxReadThrough="3.03092" /MaxDrop="6.46708" /score="5.41743429" /energy="-8.4" /TU="U484,U486,U487" /idTUdmin="U484" /TUdmin="-22" /isTUend="TRUE" CDS complement(681255..681464) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28197687" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388508.1" /db_xref="EnsemblGenomes-Gn:BSU06270" /db_xref="EnsemblGenomes-Tr:CAB12446" /db_xref="InterPro:IPR025916" /db_xref="SubtiList:BG12805" /db_xref="UniProtKB/Swiss-Prot:O34759" /translation="MSYYNKRNQEPLPKEDVSTWECTKEDCNGWTRKNFASSDTPLCP LCGSKMVDGIRSLVNLQNNSQTKTS*" gene complement(681255..681464) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" promotor_-10 complement(681497..681516) /Source="Nicolas_upshift_promotors" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(681508) /Source="Nicolas_upshifts" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" promotor_-35 complement(681533) /Source="Nicolas_upshift_promotors" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(681547..682362) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9987136; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacrylate hydrolase" /protein_id="NP_388509.1" /db_xref="EnsemblGenomes-Gn:BSU06280" /db_xref="EnsemblGenomes-Tr:CAB12447" /db_xref="GOA:O34592" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12806" /db_xref="UniProtKB/Swiss-Prot:O34592" /translation="MPYIILEDQTRLYYETHGSGTPILFIHGVLMSGQFFHKQFSVLS ANYQCIRLDLRGHGESDKVLHGHTISQYARDIREFLNAMELDHVVLAGWSMGAFVVWD YLNQFGNDNIQAAVIIDQSASDYQWEGWEHGPFDFDGLKTAMHAIQTDPLPFYESFIQ NMFAEPPAETETEWMLAEILKQPAAISSTILFNQTAADYRGTLQNINVPALLCFGEDK KFFSTAAGEHLRSNIPNATLVTFPKSSHCPFLEEPDAFNSTLLSFLDGVIGKS*" gene complement(681547..682362) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" promotor_-35 682189..682198 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 682211..682230 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 682211 /Source="Nicolas_upshifts" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(682375..683364) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388510.1" /db_xref="EnsemblGenomes-Gn:BSU06290" /db_xref="EnsemblGenomes-Tr:CAB12448" /db_xref="InterPro:IPR025062" /db_xref="SubtiList:BG12210" /db_xref="UniProtKB/Swiss-Prot:O34803" /translation="MLTHDLHEKTKHYISIYAELKTKLKWKVSHDQILMLISSAYIVN KREFDFQRFYDLSSYIKSNIGSFSTLNSHHRFTVASILDIHFQHEAKQTFQTFIDVYN EMVKLGYKRDMFTYLSALILLTGKSETTNQKEQMNMGLAVYQQMKKNHYFLTSTQNVP LAVLLGENGKGLQALQKAETCYQLLAANGFKKGQYLHQVSHILALQSEKEPEMLVSAC KQIYQSITESVKKTKDYHYPDLALLTFLEEPDIKTVLCITDELNQEKAFKWQKEMNFK IAVSLYLSEHMEKNLLMESGLYTAIETVIQAQQAAATAAIISSTAASHTHDGN*" gene complement(682375..683364) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" promotor_-10 complement(683229..683247) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(683237) /Source="Nicolas_upshifts" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" promotor_-35 complement(683263..683268) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(683386..683401) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(683407) /Source="Nicolas_upshifts" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" promotor_-35 complement(683413..683422) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(683462..685003) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" /EC_number="1.3.3.5" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="outer spore coat copper-dependent promiscuous laccase" /protein_id="NP_388511.1" /db_xref="EnsemblGenomes-Gn:BSU06300" /db_xref="EnsemblGenomes-Tr:CAB12449" /db_xref="GOA:P07788" /db_xref="InterPro:IPR001117" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011706" /db_xref="InterPro:IPR011707" /db_xref="PDB:1GSK" /db_xref="PDB:1OF0" /db_xref="PDB:1W6L" /db_xref="PDB:1W6W" /db_xref="PDB:1W8E" /db_xref="PDB:2BHF" /db_xref="PDB:2WSD" /db_xref="PDB:2X87" /db_xref="PDB:2X88" /db_xref="PDB:3ZDW" /db_xref="PDB:4A66" /db_xref="PDB:4A67" /db_xref="PDB:4A68" /db_xref="PDB:4AKO" /db_xref="PDB:4AKP" /db_xref="PDB:4AKQ" /db_xref="PDB:4Q89" /db_xref="PDB:4Q8B" /db_xref="PDB:4YVN" /db_xref="PDB:4YVU" /db_xref="SubtiList:BG10490" /db_xref="UniProtKB/Swiss-Prot:P07788" /translation="MTLEKFVDALPIPDTLKPVQQSKEKTYYEVTMEECTHQLHRDLP PTRLWGYNGLFPGPTIEVKRNENVYVKWMNNLPSTHFLPIDHTIHHSDSQHEEPEVKT VVHLHGGVTPDDSDGYPEAWFSKDFEQTGPYFKREVYHYPNQQRGAILWYHDHAMALT RLNVYAGLVGAYIIHDPKEKRLKLPSDEYDVPLLITDRTINEDGSLFYPSAPENPSPS LPNPSIVPAFCGETILVNGKVWPYLEVEPRKYRFRVINASNTRTYNLSLDNGGDFIQI GSDGGLLPRSVKLNSFSLAPAERYDIIIDFTAYEGESIILANSAGCGGDVNPETDANI MQFRVTKPLAQKDESRKPKYLASYPSVQHERIQNIRTLKLAGTQDEYGRPVLLLNNKR WHDPVTETPKVGTTEIWSIINPTRGTHPIHLHLVSFRVLDRRPFDIARYQESGELSYT GPAVPPPPSEKGWKDTIQAHAGEVLRIAATFGPYSGRYVWHCHILEHEDYDMMRPMDI TDPHK*" gene complement(683462..685003) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" downshifts complement(683475) /Source="Nicolas_upshifts" /id="D308" /incds=0 /nref=46 /ntot=93 /MaxReadThrough="2.97674" /MaxDrop="5.60726" /score="22.3755425" /energy="-9.1" /TU="U488" /idTUdmin="U488" /TUdmin="-66" /isTUend="FALSE" promotor_-10 complement(685034..685053) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-10" upshifts complement(685048) /Source="Nicolas_upshifts" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" promotor_-35 complement(685067..685076) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-35" CDS complement(685155..686564) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16547045, 16850406, 8951816, 9677314, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16547045, 16850406, 8951816, 9677314, 24142252; Product type t : transporter" /codon_start=1 /transl_table=11 /product="gamma-aminobutyrate (GABA) permease; proline permease" /protein_id="NP_388512.2" /db_xref="EnsemblGenomes-Gn:BSU06310" /db_xref="EnsemblGenomes-Tr:CAB12450" /db_xref="GOA:P46349" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="InterPro:IPR011265" /db_xref="SubtiList:BG11328" /db_xref="UniProtKB/Swiss-Prot:P46349" /translation="MNQSQSGLKKELKTRHMTMISIAGVIGAGLFVGSGSVIHSTGPG AVVSYALAGLLVIFIMRMLGEMSAVNPTSGSFSQYAHDAIGPWAGFTIGWLYWFFWVI VIAIEAIAGAGIIQYWFHDIPLWLTSLILTIVLTLTNVYSVKSFGEFEYWFSLIKVVT IIAFLIVGFAFIFGFAPGSEPVGFSNLTGKGGFFPEGISSVLLGIVVVIFSFMGTEIV AIAAGETSNPIESVTKATRSVVWRIIVFYVGSIAIVVALLPWNSANILESPFVAVLEH IGVPAAAQIMNFIVLTAVLSCLNSGLYTTSRMLYSLAERNEAPRRFMKLSKKGVPVQA IVAGTFFSYIAVVMNYFSPDTVFLFLVNSSGAIALLVYLVIAVSQLKMRKKLEKTNPE ALKIKMWLFPFLTYLTIIAICGILVSMAFIDSMRDELLLTGVITGIVLISYLVFRKRK VSEKAAANPVTQQQPDILP*" gene complement(685155..686564) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" downshifts complement(685169) /Source="Nicolas_upshifts" /id="D309" /incds=0 /nref=124 /ntot=216 /MaxReadThrough="3.22899" /MaxDrop="5.0359" /score="18.985683" /energy="-13.5" /TU="U489" /idTUdmin="U489" /TUdmin="-110" /isTUend="FALSE" CDS complement(686602..686889) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097690.1" /db_xref="EnsemblGenomes-Gn:BSU06319" /db_xref="EnsemblGenomes-Tr:CAX52577" /db_xref="UniProtKB/Swiss-Prot:C0H3X2" /translation="MIHPPQKNSDEGTLFLSSNLFAPPKIPSNPRTPVLLAFYRIVNI TQNHTANKKRNIFSTHSLKAQTKHYKFEISWYIFLHEFSTNCIFMIEFQLS*" gene complement(686602..686889) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" misc_feature complement(686605..686624) /Source="Nicolas_upshift_promotors" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(686619) /Source="Nicolas_upshifts" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" promotor_-35 686895..686902 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 686918..686937 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 686919 /Source="Nicolas_upshifts" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" CDS 686962..687834 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="secondary Mn(II) exporter, promiscuous" /protein_id="NP_388513.1" /db_xref="EnsemblGenomes-Gn:BSU06320" /db_xref="EnsemblGenomes-Tr:CAB12451" /db_xref="GOA:P46348" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG11329" /db_xref="UniProtKB/Swiss-Prot:P46348" /translation="MERYDELKKGESGALVSIAAYLVLSAIKLIIGYLFHSEALTADG LNNTTDIIASVAVLIGLRISQKPPDEDHPYGHFRAETIASLIASFIMMVVGLQVLFSA GESIFSAKQETPDMIAAWTAAGGAVLMLIVYRYNKRLAKKVKSQALLAAAADNKSDAF VSIGTFIGIVAAQFHLAWIDTVTAFVIGLLICKTAWDIFKESSHSLTDGFDIKDISAY KQTIEKISGVSRLKDIKARYLGSTVHVDVVVEVSADLNITESHDIANEIERRMKEEHA IDYSHVHMEPLEQK*" gene 686962..687834 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" downshifts 687799 /Source="Nicolas_upshifts" /id="D310" /incds=0 /nref=2 /ntot=88 /MaxReadThrough="1.72291" /MaxDrop="2.86431" /score="24.8167732" /energy="-10.2" /TU="U490" /idTUdmin="U490" /TUdmin="-22" /isTUend="TRUE" downshifts complement(688074) /Source="Nicolas_upshifts" /id="D311" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="0.65827" /MaxDrop="3.33542" /score="-0.424989042" /energy="-12.9" /TU="NA" /idTUdmin="U489" /TUdmin="-3015" /isTUend="FALSE" misc_feature 688128..688147 /Source="Nicolas_upshift_promotors" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 688138 /Source="Nicolas_upshifts" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" CDS 688184..689146 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21907250, 26933057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative MoxR-like ATPase" /protein_id="NP_388514.2" /db_xref="EnsemblGenomes-Gn:BSU06330" /db_xref="EnsemblGenomes-Tr:CAB12452" /db_xref="GOA:P94474" /db_xref="InterPro:IPR011703" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12211" /db_xref="UniProtKB/Swiss-Prot:P94474" /translation="MAYQEDLHPLLGKAVEHINRVMVGKRDIAILSLAALLAKGHVLL EDVPGVGKTMMVRALAKSIGADFKRIQFTPDLLPSDVTGVSIYNAKTMEFEYRPGPIM GNIVLADEINRTSPKTQSALLEAMEEGSVTVDGHTMQLADPFFVMATQNPVEYEGTYP LPEAQLDRFLFKLRMGYPSFNEELDVLSLQEKSHPIETLEPVIAKEDFIFLQREVQNV RADDSIKEYIVEIVQKTRQHPSVQLGVSPRGSIALMKAAQAYALLHHRDYVIPDDIQY LAPFTLPHRMMLHPEAKFEGIQAEAIVREIMSAVKVPVQRSAVR*" gene 688184..689146 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" CDS 689146..690342 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388515.2" /db_xref="EnsemblGenomes-Gn:BSU06340" /db_xref="EnsemblGenomes-Tr:CAB12453" /db_xref="InterPro:IPR002881" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12212" /db_xref="UniProtKB/Swiss-Prot:P94475" /translation="MNKKWQWLVYGWKLIILTLLTAAVFSYAMFQGGFVSWFLFYAFL PFVLYAGLLALYPLRSFQASRQMDKTQLHAGDRLGVTVTLRRKLPFPLMYMVIEDCLP EGIESLNRDGAAAKRLVFPWFKRSMTMSYELARVPRGEHHFHSVRVRTGDVLGLIEKT AFFELDDTLFVYPFYQRFSYQVNERHQEDGVSGSSPIHQHHSSVAASVRNYQPGDRFA ALDWKTSARRSQLMTKEFEPSRSKNLFLLMDRFSSDAFEEVVSVTASILHSVLKNGAG AGLASIGKEKNIFPIQEGDQHFKHMLRHLAIAHCDAADPISRYAREELGKPSVRQADQ VVVTGQLTEDMLHLAEIGGGRVTVILAKEKDAELSQAENVMIERMMKRQIRVRIMRGG RVSRVV*" gene 689146..690342 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" CDS 690364..692577 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388516.2" /db_xref="EnsemblGenomes-Gn:BSU06350" /db_xref="EnsemblGenomes-Tr:CAB12454" /db_xref="GOA:P94476" /db_xref="InterPro:IPR002931" /db_xref="InterPro:IPR025403" /db_xref="InterPro:IPR036985" /db_xref="SubtiList:BG12213" /db_xref="UniProtKB/Swiss-Prot:P94476" /translation="MPHDDHKGSRLSLLLFYFLAFLLLWEWLRPLDSFTETKHTGFFS VFIGLTFLLTFFRMRWFVTVPFCVIFTLISIHILFYQGSIFDLSWVSSFLQDVYLNIT LIQSGQWNDMIPSFRTLLFFVLLWLLVYLLHYWVIYQRRILFFFLMTVAYITILDTFT PYDATFAVIRIVLIGFFMLGLLYLERIKLMERITLPKTSVLKWFLPLSVLVLAATGFG LAAPKSEPAWPDPVPFLKKITHQDRVSAGESKIGYGNHDESLGGPFQQDATPVFTWQG KERTYFRVETKDTYTGKGWIETDTGMSYQLSNGKVENLWFDHKVATERRTVRVKVDKH YGYNHLMYPIGAETIQPKQAVSLEMNGNTEQISPISEQAGEIRNMGNYTVTYNSPVYK LDELRKVKVRKNSEEYTFSDRYMQLPDSLPERVRTLAIKLTQDHDNMFDKVKAVEDYL GSNAFTYETENVTIPKNDEDYVDQFLFETKMGYCDNFSSAMVVLLRSAGIPARWVKGY TSGEYKEAGNKNGSIYEVTNNNAHSWVEVYFPEQGWVTFEPTKGFTNPAQFTSSDTKD SGSDSSSSPKKAKEKQKEEKKQPQKEEKQKEKREPAVSKKPSASHTNAGAGLYAALAV LAVLLVAAVLLYVFRSLWIPVFAVRKLKRRSDQHAFFEAYGALLKQLKRKGLPKRDSE TLRDYAKRIDEKYDIEDMSKLTLSYERALYRNEDSSALWNDSRELWENLIKRRWS*" gene 690364..692577 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" promotor_-35 692572..692579 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 692594..692613 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 692610..692739 /Source="Nicolas_S_feature" /locus_tag="new_692610_692739" /HighExp="G180, Oxctl, G135, LBGexp, G150, Paraq, C30, LPh, MG 25, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63292099999999996" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S227" upshifts 692610 /Source="Nicolas_upshifts" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" CDS 692740..694281 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" /EC_number="6.3.5.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1312531, 21856856; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP synthetase" /protein_id="NP_388517.2" /db_xref="EnsemblGenomes-Gn:BSU06360" /db_xref="EnsemblGenomes-Tr:CAB12455" /db_xref="GOA:P29727" /db_xref="InterPro:IPR001674" /db_xref="InterPro:IPR004739" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022955" /db_xref="InterPro:IPR025777" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10647" /db_xref="UniProtKB/Swiss-Prot:P29727" /translation="MTKLVNEMILVLDFGSQYNQLITRRIREFGVYSELHPHTLTAEE IKKMNPKGIILSGGPNSVYDENSFRCDEKIFELDIPVLGICYGMQLMTHYLGGKVEAA SQREYGKANIRIEGTPDLFRDLPNEQVVWMSHGDLVVEVPEGFTVDATSHHCPNSAMS KADKKWYGVQFHPEVRHSEYGNDLLKNFVFGVCECEGEWSMENFIEIEMQKIRETVGD KQVLCALSGGVDSSVVAVLIHKAIGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFNMNV IKVDAKDRFLNKLKGVSDPEQKRKIIGNEFIYVFDDEADKLKGIDYLAQGTLYTDIIE SGTATAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGTELGIPDEIVWRQPFP GPGLGIRVLGEVTEEKLEIVRESDAILREEIANHGLERDIWQYFTVLPDIRSVGVMGD ARTYDYTIGIRAVTSIDGMTSDWARIPWDVLEVISTRIVNEVKHINRVVYDITSKPPA TIEWE*" gene 692740..694281 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" downshifts 694267 /Source="Nicolas_upshifts" /id="D312" /incds=0 /nref=247 /ntot=268 /MaxReadThrough="2.12151" /MaxDrop="7.3702" /score="22.5795134" /energy="-18.5" /TU="NA" /idTUdmin="U492" /TUdmin=0 /isTUend="TRUE" promotor_-35 694388..694392 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-35" promotor_-10 694408..694427 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-10" upshifts 694418 /Source="Nicolas_upshifts" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" misc_RNA 694425..694527 /gene="gswC" /locus_tag="BSU_misc_RNA_9" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" gene 694425..694527 /gene="gswC" /locus_tag="BSU_misc_RNA_9" downshifts 694553 /Source="Nicolas_upshifts" /id="D313" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="8.01916" /MaxDrop="4.7859" /score="24.3821572" /energy="-11.3" /TU="U493" /idTUdmin="U492" /TUdmin=286 /isTUend="FALSE" CDS 694662..695984 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3110131, 11591660, 12923093, 15849754, 16850406, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 11591660, 12923093, 15849754, 16850406, 19446032; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_388518.1" /db_xref="EnsemblGenomes-Gn:BSU06370" /db_xref="EnsemblGenomes-Tr:CAB12456" /db_xref="GOA:O34987" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG12811" /db_xref="UniProtKB/Swiss-Prot:O34987" /translation="MKTFFQFDELGTSYRNEIIGGLTTFLSMAYILFVNPITLALESV KDFPEALRIDQGAVFTATALASAAGCILMGLIARYPIAIAPGMGLNAFFAFSVVLGMG ISWQAALSGVFISGLIFVALSLTGFREKIINAIPPELKLAVGAGIGLFITFVGLQGSG IITANPSTLVTIGNIHSGPVLLTIFGVIVTVILMVLRVNAGVFIGMLLTAVAGMIFGL VPVPTQIIGSVPSLAPTFGQAWIHLPDIFSVQMLIVILTFLFVGFFDTAGTLVAVATQ AGLMKENKLPRAGRALLADSSSIVIGAVLGTSTTTSYVESSSGVAAGARSGFAAIVTG ILFLLATFFSPLLSVVTSNVTAPALIIVGALMVAPLGKIAWDKFEVAVPAFLTMIMMP LTYSIATGIAIGFIFYPITMVCKGKAKEVHPIMYGLFVVFILYFIFLK*" gene 694662..695984 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" downshifts 695962 /Source="Nicolas_upshifts" /id="D314" /incds=0 /nref=47 /ntot=153 /MaxReadThrough="4.18958" /MaxDrop="4.86237" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-86" /isTUend="FALSE" downshifts 696005 /Source="Nicolas_upshifts" /id="D315" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="3.09696" /MaxDrop="3.87785" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-43" /isTUend="FALSE" promotor_-35 696034..696043 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 696054..696194 /Source="Nicolas_S_feature" /locus_tag="new_696054_696194" /HighExp="T1.30H, T1.0H, T2.0H, T0.30H, B60, T2.30H, T-0.40H, T0.0H, T3.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S228" upshifts 696054 /Source="Nicolas_upshifts" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" promotor_-10 696056..696071 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 696195..696998 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388519.2" /db_xref="EnsemblGenomes-Gn:BSU06380" /db_xref="EnsemblGenomes-Tr:CAB12457" /db_xref="GOA:O34341" /db_xref="SubtiList:BG12812" /db_xref="UniProtKB/Swiss-Prot:O34341" /translation="MTEERKETFEEEINQSERIDADEEPLSRMSRKASRQSKQKQKQK QKPRQERGESTVKDKLASVWAAINRYCGFAFSILKSPAKTVVTDGFSHYKYGLISMLI FSIIFSIGNWFQLKASWNRPLGFGERHHAFYDGFLVVLVYLLIFFAVMVFAIWAVSRY MMKQKVTFREAAAVLGSLLVPVIAVSILWLIFAIVNIPMLTVLFTVLILFSIFFIIAL YVQRVYQAAQDAPIDYIYCVFAVVAIALLFTAVTWPFISEYITASLIPL*" gene 696195..696998 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" downshifts 696983 /Source="Nicolas_upshifts" /id="D316" /incds=0 /nref=218 /ntot=263 /MaxReadThrough="1.47691" /MaxDrop="7.03926" /score="33.0377004" /energy="-10.7" /TU="NA" /idTUdmin="U494" /TUdmin=0 /isTUend="TRUE" promotor_-35 697066..697073 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 697087..697106 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 697093..697156 /Source="Nicolas_S_feature" /locus_tag="new_697093_697156" /HighExp="B60, S2, S7, S8, Lbstat, nit, S4, BC, BT, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S229" upshifts 697093 /Source="Nicolas_upshifts" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" CDS 697157..697324 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388520.3" /db_xref="EnsemblGenomes-Gn:BSU06390" /db_xref="EnsemblGenomes-Tr:CAB12458" /db_xref="InterPro:IPR025072" /db_xref="SubtiList:BG12813" /db_xref="UniProtKB/Swiss-Prot:O34904" /translation="MADVLRRAINQKKQFLKTKLLLSEFYQGRGEQLADYTLSELEKE YKSLQKMKKEI*" gene 697157..697324 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" downshifts 697331 /Source="Nicolas_upshifts" /id="D317" /incds=0 /nref=64 /ntot=163 /MaxReadThrough="2.85884" /MaxDrop="5.66286" /score="29.2645456" /energy="-9" /TU="NA" /idTUdmin="U495" /TUdmin="-2" /isTUend="TRUE" promotor_-35 697375..697381 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 697396..697414 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 697399..697485 /Source="Nicolas_S_feature" /locus_tag="new_697399_697485" /HighExp="Etha, Gly, M9-stat, Sw, B60, S4, S6, LPhT, S3, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S230" upshifts 697399 /Source="Nicolas_upshifts" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" promotor_-35 697464..697471 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 697485..697504 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 697487 /Source="Nicolas_upshifts" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" CDS 697538..698092 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388521.2" /db_xref="EnsemblGenomes-Gn:BSU06400" /db_xref="EnsemblGenomes-Tr:CAB12459" /db_xref="GOA:O34624" /db_xref="InterPro:IPR019264" /db_xref="InterPro:IPR022930" /db_xref="SubtiList:BG12814" /db_xref="UniProtKB/Swiss-Prot:O34624" /translation="MMQTILSNGIAMVLIILIINIVYVSFFTIRMILTLKGQRYLAAG ISTIEILVYVTGLSLVLDNLDQIQNVIAYALGYGLGVIVGMKIEEKLALGYIMVNVIT KELDLDLPKQLREKGYGVTNWVAGGLEGDRTALQILTPRRYELQLYDTIKTLDSKAFI IAYEPKTIHGGFWVKAVKKRRIKE*" gene 697538..698092 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" CDS 698092..698289 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388523.1" /db_xref="EnsemblGenomes-Gn:BSU06410" /db_xref="EnsemblGenomes-Tr:CAB12461" /db_xref="InterPro:IPR025930" /db_xref="SubtiList:BG12816" /db_xref="UniProtKB/Swiss-Prot:O34700" /translation="MAKPKKKKFEVTEQQTIDAVLQQMKEEGYLPVRRMEEPIFMEKK ENGSIQIVPCGKKIVFEGKLI*" gene 698092..698289 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" downshifts 698279 /Source="Nicolas_upshifts" /id="D318" /incds=0 /nref=2 /ntot=91 /MaxReadThrough="2.80904" /MaxDrop="2.65424" /score="17.462689" /energy="-17.6" /TU="U496" /idTUdmin="U497" /TUdmin=0 /isTUend="TRUE" promotor_-35 698335..698342 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 698357..698376 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 698359 /Source="Nicolas_upshifts" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" misc_RNA 698369..698471 /gene="gswD" /locus_tag="BSU_misc_RNA_10" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" gene 698369..698471 /gene="gswD" /locus_tag="BSU_misc_RNA_10" S_feature 698472..698611 /Source="Nicolas_S_feature" /locus_tag="new_698472_698611" /HighExp="MG 10, MG 15, MG t5, BMM, MG 25, MG 5, HPh, GM 45, GM 90, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S231" CDS 698612..699100 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" /EC_number="5.4.99.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12787499, 16138311, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide mutase" /protein_id="NP_388524.1" /db_xref="EnsemblGenomes-Gn:BSU06420" /db_xref="EnsemblGenomes-Tr:CAB12462" /db_xref="GOA:P12044" /db_xref="InterPro:IPR000031" /db_xref="InterPro:IPR024694" /db_xref="InterPro:IPR033747" /db_xref="InterPro:IPR035893" /db_xref="SubtiList:BG10700" /db_xref="UniProtKB/Swiss-Prot:P12044" /translation="MQPLVGIIMGSTSDWETMKHACDILDELNVPYEKKVVSAHRTPD FMFEYAETARERGIKVIIAGAGGAAHLPGMTAAKTTLPVIGVPVQSKALNGMDSLLSI VQMPGGVPVATTSIGKAGAVNAGLLAAQILSAFDEDLARKLDERRENTKQTVLESSDQ LV*" gene 698612..699100 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" CDS 699093..700235 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" /EC_number="6.3.4.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8998996, 9683488, 21931218, 25372694; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide synthase" /protein_id="NP_388525.2" /db_xref="EnsemblGenomes-Gn:BSU06430" /db_xref="EnsemblGenomes-Tr:CAB12463" /db_xref="GOA:P12045" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005875" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10701" /db_xref="UniProtKB/Swiss-Prot:P12045" /translation="MSKQIIYPGAVIGIIGGGQLGKMMAVSAKQMGYKVAVVDPVKDS PCGQVADVEITAHYNDREAIRKLAEISDIITYEFENIDYDALHWLKDHAYLPQGSELL LITQNRETEKKAIQSAGCEVAPYSIVKTKNELKQAVQELRLPAVLKTCRGGYDGKGQF VIKEEAQMEQAAALLEHGTCILESWVSFKMELSVIVVRSVNGEISTFPTAENIHHNNI LFQSIVPARVEKGIQQKAADLAVKLADELNLVGPLAVEMFLTEDGELLVNELAPRPHN SGHYTLDLCETSQFEQHIRAVCGLPLGKTDLLKPGMMVNLLGDEVKLVEEDPELLKEA KLYIYGKHEIKKGRKMGHITFMKQPEDEWIQEITNKWMNRDGGQAE*" gene 699093..700235 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" CDS 700232..701527 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" /EC_number="4.3.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9622500, 9683488, 9890879, 11063569, 12787499; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate lyase" /protein_id="NP_388526.1" /db_xref="EnsemblGenomes-Gn:BSU06440" /db_xref="EnsemblGenomes-Tr:CAB12464" /db_xref="GOA:P12047" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004769" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR019468" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="PDB:1F1O" /db_xref="SubtiList:BG10702" /db_xref="UniProtKB/Swiss-Prot:P12047" /translation="MIERYSRPEMSAIWTDENRFQAWLEVEILACEAWAELGVIPKED VKVMRENASFDINRILEIEKDTRHDVVAFTRAVSESLGEERKWVHYGLTSTDVVDTAL SYLLKQANDILLKDLERFVDIIKEKAKEHKYTVMMGRTHGVHAEPTTFGLKLALWHEE MKRNLERFKQAKAGIEVGKISGAVGTYANIDPFVEQYVCEKLGLKAAPISTQTLQRDR HADYMATLALIATSIEKFAVEIRGLQKSETREVEEFFAKGQKGSSAMPHKRNPIGSEN MTGMARVIRGYMMTAYENVPLWHERDISHSSAERIILPDATIALNYMLNRFSNIVKNL TVFPENMKRNMDRTLGLIYSQRVLLALIDTGLTREEAYDTVQPKAMEAWEKQVPFREL VEAEEKITSRLSPEKIADCFDYNYHLKNVDLIFERLGLA*" gene 700232..701527 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" promotor_-10 complement(700537..700556) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(700558) /Source="Nicolas_upshifts" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(700571..700578) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 701601..702326 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" /EC_number="6.3.2.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2495272, 9683488, 10784038, 12787499, 26118696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole succinocarboxamide synthetase" /protein_id="NP_388527.1" /db_xref="EnsemblGenomes-Gn:BSU06450" /db_xref="EnsemblGenomes-Tr:CAB12465" /db_xref="GOA:P12046" /db_xref="InterPro:IPR001636" /db_xref="InterPro:IPR018236" /db_xref="InterPro:IPR028923" /db_xref="InterPro:IPR033934" /db_xref="SubtiList:BG10703" /db_xref="UniProtKB/Swiss-Prot:P12046" /translation="MNIVKNELLYEGKAKKIYKTDDENTLYVVYKDSATAFNGEKKAE ISGKGRLNNEISSLIFKHLHAKGINNHFIERISETEQLIKKVTIVPLEVVVRNVVAGS MSKRLGIPEGTELEQPIIEFYYKDDALGDPLITEDHIWLLKAATPEQVETIKSITTIV NEELQSIFDDCHVRLIDFKLEFGLDAEGQVLLADEISPDTCRLWDKETNEKLDKDLFR RNLGSLTDAYEEIFNRLGGIHHV*" gene 701601..702326 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" CDS 702319..702573 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10784038, 12787499" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10784038, 12787499; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for phosphoribosylformylglycinamidine synthetase activity" /protein_id="NP_388528.1" /db_xref="EnsemblGenomes-Gn:BSU06460" /db_xref="EnsemblGenomes-Tr:CAB12466" /db_xref="GOA:P12049" /db_xref="InterPro:IPR003850" /db_xref="InterPro:IPR036604" /db_xref="PDB:1T4A" /db_xref="PDB:1TWJ" /db_xref="SubtiList:BG10704" /db_xref="UniProtKB/Swiss-Prot:P12049" /translation="MYKVKVYVSLKESVLDPQGSAVQHALHSMTYNEVQDVRIGKYME LTIEKSDRDLDVLVKEMCEKLLANTVIEDYRYEVEEVVAQ*" gene 702319..702573 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" CDS 702570..703253 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301530, 15301532, 10784038, 9683488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301530, 15301532, 10784038, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit I" /protein_id="NP_388529.1" /db_xref="EnsemblGenomes-Gn:BSU06470" /db_xref="EnsemblGenomes-Tr:CAB12467" /db_xref="GOA:P12041" /db_xref="InterPro:IPR010075" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10706" /db_xref="UniProtKB/Swiss-Prot:P12041" /translation="MKFAVIVLPGSNCDIDMYHAVKDELGHEVEYVWHEETSLDGFDG VLIPGGFSYGDYLRCGAIARFANIMPAVKQAAAEGKPVLGVCNGFQILQELGLLPGAM RRNKDLKFICRPVELIVQNDETLFTASYEKGESITIPVAHGEGNFYCDDETLATLKEN NQIAFTYGSNINGSVSDIAGVVNEKGNVLGMMPHPERAVDELLGSADGLKLFQSIVKN WRETHVTTA*" gene 702570..703253 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" CDS 703237..705465 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301532, 10784038, 9683488, 21671997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301532, 10784038, 9683488, 21671997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit II" /protein_id="NP_388530.2" /db_xref="EnsemblGenomes-Gn:BSU06480" /db_xref="EnsemblGenomes-Tr:CAB12468" /db_xref="GOA:P12042" /db_xref="InterPro:IPR010074" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10705" /db_xref="UniProtKB/Swiss-Prot:P12042" /translation="MSLLLEPSKEQIKEEKLYQQMGVSDDEFALIESILGRLPNYTEI GIFSVMWSEHCSYKNSKPILRKFPTSGERVLQGPGEGAGIVDIGDNQAVVFKIESHNH PSALEPYQGAATGVGGIIRDVFSMGARPIAVLNSLRFGELTSPRVKYLFEEVVAGIAG YGNCIGIPTVGGEVQFDSSYEGNPLVNAMCVGLINHEDIKKGQAKGVGNTVMYVGAKT GRDGIHGATFASEEMSDSSEEKRSAVQVGDPFMEKLLLEACLEVIQCDALVGIQDMGA AGLTSSSAEMASKAGSGIEMNLDLIPQRETGMTAYEMMLSESQERMLLVIERGREQEI IDIFDKYDLEAVSVGHVTDDKMLRLTHKGEVVCELPVDALAEEAPVYHKPSQEPAYYR EFLETDVPAPQIEDANEMLKALLQQPTIASKEWVYDQYDYMVRTNTVVAPGSDAGVLR IRGTKKALAMTTDCNARYLYLDPEVGGKIAVAEAARNIICSGAEPLAVTDNLNFGNPE KPEIFWQIEKAADGISEACNVLSTPVIGGNVSLYNESNGTAIYPTPVIGMVGLIEDTA HITTQHFKQAGDLVYVIGETKPEFAGSELQKMTEGRIYGKAPQIDLDVELSRQKALLD AIKKGFVQSAHDVSEGGLGVAIAESVMTTENLGANVTVEGEAALLFSESQSRFVVSVK KEHQAAFEATVKDAVHIGEVTADGILAIQNQDGQQMIHAQTKELERVWKGAIPCLLKS KA*" gene 703237..705465 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" downshifts complement(703485) /Source="Nicolas_upshifts" /id="D319" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="0.69202" /MaxDrop="3.99287" /score="-6.56256716" /energy="-16.7" /TU="NA" /idTUdmin="U499" /TUdmin="-3147" /isTUend="FALSE" CDS 705441..706871 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" /EC_number="2.4.2.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 10049369, 12787499, 16321950, 17981983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 10049369, 12787499, 16321950, 17981983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine phosphoribosylpyrophosphate amidotransferase" /protein_id="NP_388531.2" /db_xref="EnsemblGenomes-Gn:BSU06490" /db_xref="EnsemblGenomes-Tr:CAB12469" /db_xref="GOA:P00497" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005854" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR035584" /db_xref="PDB:1AO0" /db_xref="PDB:1GPH" /db_xref="SubtiList:BG10707" /db_xref="UniProtKB/Swiss-Prot:P00497" /translation="MLAEIKGLNEECGVFGIWGHEEAPQITYYGLHSLQHRGQEGAGI VATDGEKLTAHKGQGLITEVFQNGELSKVKGKGAIGHVRYATAGGGGYENVQPLLFRS QNNGSLALAHNGNLVNATQLKQQLENQGSIFQTSSDTEVLAHLIKRSGHFTLKDQIKN SLSMLKGAYAFLIMTETEMIVALDPNGLRPLSIGMMGDAYVVASETCAFDVVGATYLR EVEPGEMLIINDEGMKSERFSMNINRSICSMEYIYFSRPDSNIDGINVHSARKNLGKM LAQESAVEADVVTGVPDSSISAAIGYAEATGIPYELGLIKNRYVGRTFIQPSQALREQ GVRMKLSAVRGVVEGKRVVMVDDSIVRGTTSRRIVTMLREAGATEVHVKISSPPIAHP CFYGIDTSTHEELIASSHSVEEIRQEIGADTLSFLSVEGLLKGIGRKYDDSNCGQCLA CFTGKYPTEIYQDTVLPHVKEAVLTK*" gene 705441..706871 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" S_feature 706872..706972 /Source="Nicolas_S_feature" /locus_tag="new_706872_706972" /HighExp="MG 15, MG 25, MG 10, MG 5, aero, S0, MG t5, Gly, LPh, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S232" CDS 706973..708013 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" /EC_number="6.3.3.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10508786, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole synthetase" /protein_id="NP_388532.2" /db_xref="EnsemblGenomes-Gn:BSU06500" /db_xref="EnsemblGenomes-Tr:CAB12470" /db_xref="GOA:P12043" /db_xref="InterPro:IPR004733" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10708" /db_xref="UniProtKB/Swiss-Prot:P12043" /translation="MSEAYKNAGVDIEAGYEAVKRMKKHVERTKRLGVMGSLGGFGGM FDLSELSYQKPVLISGTDGVGTKLKLAFSMDKHDTIGVDAVAMCVNDVLAQGAEPLFF LDYLAVGKADPVKIEQIVQGVAEGCEQSGSALVGGETAEMPGLYTADEYDIAGFSVGV AEKDEIVTGEKIEEGHLLIGLSSSGLHSNGFSLVRKVLLDDAELDLDTTYEPFERPLG EELLEPTRIYVKPVLAAVKSGKIDGMAHVTGGGFIENIPRMLPEGLSAEIDHGSWPIP PIFSFLQEYGKLKEEDMFNVFNMGIGFVLAVKEEHLTDVIGTLESHGEKAYLIGRVKK GEGVTFGGAALS*" gene 706973..708013 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" CDS 708010..708597 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" /EC_number="2.1.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10569930, 12787499, 19574646; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase" /protein_id="NP_388533.2" /db_xref="EnsemblGenomes-Gn:BSU06510" /db_xref="EnsemblGenomes-Tr:CAB12471" /db_xref="GOA:P12040" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR004607" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG10709" /db_xref="UniProtKB/Swiss-Prot:P12040" /translation="MKKFAVFASGNGSNFEAIVTRLKEENWDASAALLVCDKPQAKVI ERAEAFHIPSFAFEPKSYENKAAFEQAIIEQLRLHEVELIALAGYMRLIGDTLLQAYG GKIINIHPSLLPAFPGIDAVGQAFRAGVKVAGITVHYVDEGMDTGPIIAQKAIEIDEH DTLETIEQRIHKLEHKWYPSVIKQLLGLNNRGEKA*" gene 708010..708597 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" misc_feature 708020..708034 /Source="Nicolas_upshift_promotors" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 708029 /Source="Nicolas_upshifts" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" promotor_-10 complement(708296..708314) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(708303) /Source="Nicolas_upshifts" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(708330..708335) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 708594..710132 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" /EC_number="2.1.2.3" /EC_number="3.5.4.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12787499, 1937050, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused phosphoribosylaminoimidazole carboxy formyl formyltransferase; inosine-monophosphate cyclohydrolase" /protein_id="NP_388534.2" /db_xref="EnsemblGenomes-Gn:BSU06520" /db_xref="EnsemblGenomes-Tr:CAB12472" /db_xref="GOA:P12048" /db_xref="InterPro:IPR002695" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024051" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10710" /db_xref="UniProtKB/Swiss-Prot:P12048" /translation="MTIKRALISVSDKTNLVPFVKELTELGVEVISTGGTKKLLQENG VDVIGISEVTGFPEIMDGRLKTLHPNIHGGLLAVRGNEEHMAQINEHGIQPIDLVVVN LYPFKETISKEDVTYEEAIENIDIGGPGMLRAASKNHQDVTVIVDPADYSPVLNQIKE EGSVSLQKKRELAAKVFRHTAAYDALIADYLTNVVGEKEPEQFTVTFEKKQSLRYGEN PHQEATFYQTALPVKGSIAQAEQLHGKELSYNNIKDADAAVQIVREFTEPAAVAVKHM NPCGVGTGKTIAEAFDRAFEADKTSIFGGIIALNREVDKATAEALHNIFLEIIIAPSF SQEALDVLTAKKNLRLLTLDVSAAVQKEKQLTSVQGGLLIQDLDMHGFDDAEISIPTK REPNEQEWEDLKLAWKVVKHVKSNAIVLAKDNMTVGVGAGQMNRVGSAKIAIEQAGEK AKGSALGSDAYFPMPDTVEEAAKAGVTAIIQPGGSIRDEDSIKKADEYGIAMVFTGIR HFKH*" gene 708594..710132 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" CDS 710148..711416 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" /EC_number="6.3.4.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 12787499, 16321950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide synthetase" /protein_id="NP_388535.1" /db_xref="EnsemblGenomes-Gn:BSU06530" /db_xref="EnsemblGenomes-Tr:CAB12473" /db_xref="GOA:P12039" /db_xref="InterPro:IPR000115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR020559" /db_xref="InterPro:IPR020560" /db_xref="InterPro:IPR020561" /db_xref="InterPro:IPR020562" /db_xref="InterPro:IPR037123" /db_xref="PDB:2XCL" /db_xref="PDB:2XD4" /db_xref="SubtiList:BG10711" /db_xref="UniProtKB/Swiss-Prot:P12039" /translation="MNVLIIGKGGREHTLAWKAAQSSLVENVFAAPGNDGMAASAQLV NIEESDHAGLVSFAKQNQVGLTIVGPEVPLIEGLVDEFEKAGLHVFGPSKAAAIIEGS KQFAKDLMKKYDIPTAEYETFTSFDEAKAYVQEKGAPIVIKADGLAAGKGVTVAMTEE EAIACLHDFLEDEKFGDASASVVIEEYLSGEEFSLMAFVKGEKVYPMVIAQDHKRAFD GDKGPNTGGMGAYSPVPQISEETVRHAVETIVKPAAKAMVQEGRSFTGVLYAGLMLTE NGSKVIEFNARFGDPETQVVLPRMESDLVQVLLDLLDDKEVDLRWKDTAAVSVVLASE GYPESYAKGTPIGSLAAETEQVVVFHAGTKAEGGEFVTNGGRVANVTAFDETFEAARD RVYKAVDEIFKPGLFFRKDIGARALKAAQK*" gene 710148..711416 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" downshifts 711401 /Source="Nicolas_upshifts" /id="D320" /incds=0 /nref=140 /ntot=249 /MaxReadThrough="2.77191" /MaxDrop="5.90939" /score="30.0999687" /energy="-11.4" /TU="NA" /idTUdmin="U500" /TUdmin=6 /isTUend="TRUE" CDS complement(711456..711875) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388536.2" /db_xref="EnsemblGenomes-Gn:BSU06540" /db_xref="EnsemblGenomes-Tr:CAB12474" /db_xref="GOA:O31497" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019885" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12874" /db_xref="UniProtKB/Swiss-Prot:O31497" /translation="MDDTDLQILSHLQRNGRLTMVELGKLVGLSSPSAAERVRKLEDK GVITGYSANICYEKLNKHVTAFILMEPKSCKHYAAFATSHPDVAENHRITGMYSYVTK VVTESVHTLEDFIDTSMAHGKPTTLVVLSSSSCHPAF*" gene complement(711456..711875) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" misc_feature complement(711945..711964) /Source="Nicolas_upshift_promotors" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(711954) /Source="Nicolas_upshifts" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" CDS 712019..713293 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26319875, 27723097, 24678831; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_388537.2" /db_xref="EnsemblGenomes-Gn:BSU06550" /db_xref="EnsemblGenomes-Tr:CAB12475" /db_xref="GOA:O34560" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12817" /db_xref="UniProtKB/Swiss-Prot:O34560" /translation="MLPELQRSITWIQGTALTIGAVLGCGILILPSVTADTAGPASLF VWVFMSFLSFFLVGTLARLVKIAPSAGGITAYVQLAFQKKAGAILGWIMLGSVPIGVP IIALTGAHYVSYITEAADWQITLIAGCMLAISILLHMRGIQLSANISTLVICVIVFLL VTSIAVSLPHVTIAEFKPFLPHGWSAAGSVSVMIFFSFVGWEMITPLAEEFHRPEKDV PLSLFLAASCVAGLYIMLSFVTVGTHSYGENGEIASLAMLISKGAGESGVYVTVCLAL FITFATIHANIAGFSRMVYALAREGHIPVFFGKLSATKRTPIRVLTAMAAVFGLVLAA HGLFQIDLTTLLKGPSAAFIASYICTMAAALKLLGRRDIGWWMALGAFVACAVIYSFS GWALLYPAVLAAAGYFYMKTKGGHKKKLDHVL*" gene 712019..713293 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" downshifts 713242 /Source="Nicolas_upshifts" /id="D321" /incds=0 /nref=4 /ntot=64 /MaxReadThrough="0.796809999999999" /MaxDrop="2.92696" /score="1.68718502" /energy="-14.2" /TU="NA" /idTUdmin="U498" /TUdmin=1825 /isTUend="FALSE" CDS complement(713308..713535) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097691.1" /db_xref="EnsemblGenomes-Gn:BSU06559" /db_xref="EnsemblGenomes-Tr:CAX52578" /db_xref="GOA:C0H3X3" /db_xref="InterPro:IPR021309" /db_xref="UniProtKB/Swiss-Prot:C0H3X3" /translation="MKPNISLINAVFRIACGLTIMSAASAKFTKKPWCRMHLFYIFMG AMKAGSGILRFCPVTYMFQHSDSGNNEHQNG*" gene complement(713308..713535) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" downshifts complement(713319) /Source="Nicolas_upshifts" /id="D322" /incds=0 /nref=29 /ntot=46 /MaxReadThrough="0.14199" /MaxDrop="6.82335" /score="34.1397958" /energy="-13.9" /TU="NA" /idTUdmin="U504" /TUdmin=0 /isTUend="TRUE" S_feature complement(713536..713956) /Source="Nicolas_S_feature" /locus_tag="new_713536_713956_c" /HighExp="S8, S7, S5, S6, S4, ferm, nit, BT, Pyr, T5.0H" /AntisenseName="yerA" /AntisenseCor="0.38264258041500998" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S233" promotor_-35 713603..713608 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 713619 /Source="Nicolas_upshifts" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" promotor_-10 713622..713641 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 713664..715406 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23109554; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenine deaminase YerA" /protein_id="NP_388538.1" /db_xref="EnsemblGenomes-Gn:BSU06560" /db_xref="EnsemblGenomes-Tr:CAB12476" /db_xref="GOA:O34909" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG12829" /db_xref="UniProtKB/Swiss-Prot:O34909" /translation="MSERTFNWKNKDIRAQVDVVDSKLLPTLLLRNALVLNPYVKQWL KKNIWIYQDRIVYVGHELPNRAEEIHTIDCEGKYIVPGYIEPHAHPFQIYNPQTLAEY VSQYGTTTFVNDNLFLLLQSGKKKALTILNELKKQPVQYFWWSRYDLQTEVLNEDHVL PFDVRKQWIEHPDVIQGGEMTGWPRLVDGDDLMLHCMQATKKQRKRIEGHFPGASDKT LTKMKLFGADCDHEAMTGDEVMRRLELGYYVSLRNSSIRPDVRKILQELHEKGFRYYD HFFYTTDGATPNFYKGGMTNELIRIALEEGVPAIDAYNMASFNIAKYYQMDDYLGVVG PGRLASLNILEDPLNPNPVTVLSKGTILRENGCDLKAFTKTDWHKGGLVPLELSYDMT MDDLQFSMPMGVKMRNAVIMEPYMIEIDNSMEQLSFDHDESYLTMLDRHGKWRVNTMI KGFASSVQGFVSSFTTTGDIVAIGKNKADMLLAFARMKEIGGGIVLAENGNILHEIPL ALCGCASSEAYEDVLEKEQKLRDLLTERGYEFCDPIYTLLFLQSTHLPYIRITPRGIF DVMKKTVLFPSIMR*" gene 713664..715406 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" promotor_-10 complement(713941..713952) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(713956) /Source="Nicolas_upshifts" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" promotor_-35 complement(713966..713972) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 713987 /Source="Nicolas_upshifts" /id="D323" /incds=1 /nref=13 /ntot=109 /MaxReadThrough="7.92321" /MaxDrop="3.44855" /score="1.68718502" /energy="-14.2" /TU="U503" /idTUdmin="U498" /TUdmin=2570 /isTUend="FALSE" promotor_-35 715380..715386 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 715398 /Source="Nicolas_upshifts" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" promotor_-10 715399..715418 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 715433..716428 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12073041; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388539.1" /db_xref="EnsemblGenomes-Gn:BSU06570" /db_xref="EnsemblGenomes-Tr:CAB12477" /db_xref="GOA:O34968" /db_xref="InterPro:IPR021416" /db_xref="InterPro:IPR023158" /db_xref="InterPro:IPR035328" /db_xref="PDB:2PSB" /db_xref="SubtiList:BG12830" /db_xref="UniProtKB/Swiss-Prot:O34968" /translation="MKKWMTVCALCFVFFLLVSCQQKDAVPDTAKKLKAPLTGLKTEQ KVTERRPVAVVVNNHPKARPQSGLSKADIVIEALAEGQITRFLAIFQSQMPETVGPVR SAREYFVTLSNGFDSIFVHHGWSPGAKKQLESGAADYMNGLDFDGSLFWRADFSKPPH NSYTSYDYIKKAAEQKGYKLKQETNPLLFQTSDAKPANESYNVRVDYGTNNVTNLVEY NYDKKAEFYTRSSDGVITTDRETGKPVAMQNIFIVEASHHIIDQDGRRDIDLESGGKG LLFQHGNVIETDWKQVNGRIVPVKDGKWLPFVPGKTWINIVPDLDAASISKGEGV*" gene 715433..716428 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" CDS 716431..716745 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor-histidine operons" /protein_id="NP_388540.1" /db_xref="EnsemblGenomes-Gn:BSU06580" /db_xref="EnsemblGenomes-Tr:CAB12478" /db_xref="GOA:Q7BVT7" /db_xref="InterPro:IPR000831" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013368" /db_xref="SubtiList:BG12831" /db_xref="UniProtKB/Swiss-Prot:Q7BVT7" /translation="MQIDKLRGKELDQLFNSILSLKDLEECYRFFDDLCTINEIQSLA QRLEVARMLREGNTYHKIETETGASTATISRVKRCLNYGNDAYEMALDRVKETETESS SK*" gene 716431..716745 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" downshifts 716608 /Source="Nicolas_upshifts" /id="D324" /incds=1 /nref=1 /ntot=25 /MaxReadThrough="7.1005" /MaxDrop="2.3494" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-374" /isTUend="FALSE" downshifts 716750 /Source="Nicolas_upshifts" /id="D325" /incds=0 /nref=78 /ntot=262 /MaxReadThrough="3.58776" /MaxDrop="5.59364" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-232" /isTUend="FALSE" CDS complement(716780..718357) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" /EC_number="1.4.1.13" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15805528, 17114254, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative osmotic shock glutamate synthase subunit (flavoprotein subunit, ferredoxin-dependent)" /protein_id="NP_388541.1" /db_xref="EnsemblGenomes-Gn:BSU06590" /db_xref="EnsemblGenomes-Tr:CAB12479" /db_xref="GOA:O34849" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024188" /db_xref="InterPro:IPR027283" /db_xref="SubtiList:BG12832" /db_xref="UniProtKB/Swiss-Prot:O34849" /translation="METIIIALIAFIIGIIAIPIVLFAWIYIKDEKQQEHSILRNYPV IGRFRYILEKIGPELRQYLYSNDNEEQPFSRKEYEQTVISGKYKSRMMGFGSVRDFDK PGYYIRNAMFPKQREEMHVNQTPKIETQIYKMDADNLFKRKEHAEHIKADPYFLHPDD VQVIGEHTCEKPFYVKGLVGQSAMSYGSLGERAVTALSKGLHLAGGTWMNTGEGGLSE YHLKGGADIICQIGPGLFGVRKRNGEFSWEEFKRKSRIDQIKAFELKLAQGAKTRGGH VDGAKVSEEVADIRNVEPGKSIDSPNRFYEFSNPPEMLDFIEKLRDVGQKPVGIKLVA GHPEELHELFSHMQKSGKHPDFITIDGSEGGTGASFYELADTVGLPIMTALPIVDTLL KQYGLRSQLKIFASGKLLTPDKIAVALALGADFVNIARGMMFSVGCIRALVCHTNTCP AGVATTDPKLQKALSVEEKQHRVCNYVISLREGLFNLAAAAGINSPIHFSKEHVVYRK EDGSIINIDNLIHQFVS*" gene complement(716780..718357) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" downshifts complement(716794) /Source="Nicolas_upshifts" /id="D326" /incds=0 /nref=7 /ntot=24 /MaxReadThrough="2.99325" /MaxDrop="5.6389" /score="34.8793815" /energy="-15.8" /TU="U506" /idTUdmin="U506" /TUdmin="-88" /isTUend="FALSE" promotor_-10 complement(718371..718390) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(718390) /Source="Nicolas_upshifts" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" promotor_-35 complement(718405..718411) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 718554..718557 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 718571 /Source="Nicolas_upshifts" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" promotor_-10 718574..718593 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 718622..719308 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16377641, 21761520, 21214173, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16377641, 21761520, 21214173, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heptaprenylglyceryl-phosphate synthase" /protein_id="NP_388542.1" /db_xref="EnsemblGenomes-Gn:BSU06600" /db_xref="EnsemblGenomes-Tr:CAB12480" /db_xref="GOA:O34790" /db_xref="InterPro:IPR008205" /db_xref="PDB:1VIZ" /db_xref="PDB:3VZX" /db_xref="PDB:3VZY" /db_xref="PDB:3VZZ" /db_xref="PDB:3W00" /db_xref="SubtiList:BG12833" /db_xref="UniProtKB/Swiss-Prot:O34790" /translation="MYDVTEWKHVFKLDPNKDLPDEQLEILCESGTDAVIIGGSDGVT EDNVLRMMSKVRRFLVPCVLEVSAIEAIVPGFDLYFIPSVLNSKNADWIVGMHQKAMK EYGELMSMEEIVAEGYCIANPDCKAAALTEADADLNMDDIVAYARVSELLQLPIFYLE YSGVLGDIEAVKKTKAVLETSTLFYGGGIKDAETAKQYAEHADVIVVGNAVYEDFDRA LKTVAAVKGE*" gene 718622..719308 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" CDS 719370..721589 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 12682299, 14594837, 16267290, 26070154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_388543.1" /db_xref="EnsemblGenomes-Gn:BSU06610" /db_xref="EnsemblGenomes-Tr:CAB12481" /db_xref="GOA:O34580" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR005751" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG12834" /db_xref="UniProtKB/Swiss-Prot:O34580" /translation="MNYISNQLLSGLNPVQQEAVKTTDGPLLLMAGAGSGKTRVLTHR IAYLMAEKHVAPWNILAITFTNKAAREMKERVESILGPGADDIWISTFHSMCVRILRR DIDRIGINRNFSILDTADQLSVIKGILKERNLDPKKFDPRSILGTISSAKNELTEPEE FSKVAGGYYDQVVSDVYADYQKKLLKNQSLDFDDLIMTTIKLFDRVPEVLEFYQRKFQ YIHVDEYQDTNRAQYMLVKQLAERFQNLCVVGDSDQSIYRWRGADITNILSFEKDYPN ASVILLEQNYRSTKRILRAANEVIKNNSNRKPKNLWTENDEGIKISYYRGDNEFGEGQ FVAGKIHQLHSTGKRKLSDIAILYRTNAQSRVIEETLLKAGLNYNIVGGTKFYDRKEI KDILAYLRLVSNPDDDISFTRIVNVPKRGVGATSLEKIASYAAINGLSFFQAIQQVDF IGVSAKAANALDSFRQMIENLTNMQDYLSITELTEEILDKTEYREMLKAEKSIEAQSR LENIDEFLSVTKNFEQKSEDKTLVAFLTDLALIADIDQLDQKEEESGGKDAITLMTLH AAKGLEFPVVFLMGLEEGVFPHSRSLMEEAEMEEERRLAYVGITRAEQELYLTNAKMR TLFGRTNMNPESRFIAEIPDDLLENLNEKKETRATSARKMQPRRGPVSRPVSYASKTG GDTLNWAVGDKAGHKKWGTGTVVSVKGEGEGTELDIAFPSPVGVKRLLAAFAPIEKQ* " gene 719370..721589 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" CDS 721613..723619 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" /EC_number="6.5.1.2" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:164915, 11095673, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 164915, 11095673, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ligase (NAD-dependent)" /protein_id="NP_388544.1" /db_xref="EnsemblGenomes-Gn:BSU06620" /db_xref="EnsemblGenomes-Tr:CAB12482" /db_xref="GOA:O31498" /db_xref="InterPro:IPR001357" /db_xref="InterPro:IPR001679" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004149" /db_xref="InterPro:IPR004150" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013839" /db_xref="InterPro:IPR013840" /db_xref="InterPro:IPR018239" /db_xref="InterPro:IPR033136" /db_xref="InterPro:IPR036420" /db_xref="SubtiList:BG12835" /db_xref="UniProtKB/Swiss-Prot:O31498" /translation="MDKETAKQRAEELRRTINKYSYEYYTLDEPSVPDAEYDRLMQEL IAIEEEHPDLRTPDSPTQRVGGAVLEAFQKVTHGTPMLSLGNAFNADDLRDFDRRVRQ SVGDDVAYNVELKIDGLAVSLRYEDGYFVRGATRGDGTTGEDITENLKTIRNIPLKMN RELSIEVRGEAYMPKRSFEALNEERIKNEEEPFANPRNAAAGSLRQLDPKIAAKRNLD IFVYSIAELDEMGVETQSQGLDFLDELGFKTNQERKKCGSIEEVITLIDELQAKRADL PYEIDGIVIKVDSLDQQEELGFTAKSPRWAIAYKFPAEEVVTKLLDIELNVGRTGVIT PTAILEPVKVAGTTVSRASLHNEDLIKEKDIRILDKVVVKKAGDIIPEVVNVLVDQRT GEEKEFSMPTECPECGSELVRIEGEVALRCINPECPAQIREGLIHFVSRNAMNIDGLG ERVITQLFEENLVRNVADLYKLTKERVIQLERMGEKSTENLISSIQKSKENSLERLLF GLGIRFIGSKAAKTLAMHFESLENLKKASKEELLAVDEIGEKMADAVITYFHKEEMLE LLNELQELGVNTLYKGPKKVKAEDSDSYFAGKTIVLTGKLEELSRNEAKAQIEALGGK LTGSVSKNTDLVIAGEAAGSKLTKAQELNIEVWNEEQLMGELKK*" gene 721613..723619 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" CDS 723635..724825 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388545.1" /db_xref="EnsemblGenomes-Gn:BSU06630" /db_xref="EnsemblGenomes-Tr:CAB12483" /db_xref="GOA:O34629" /db_xref="InterPro:IPR011426" /db_xref="SubtiList:BG12836" /db_xref="UniProtKB/Swiss-Prot:O34629" /translation="MKKTLALAATAAVLMLSACSSGFGGEKEEEITQKTAKSSEKAIV PKYNISDSYYKMVLPFKAGKARGLTTEQLNTRLDIDEFETGLMRLAQDSFSTDDYLFQ EGQYLDEDTVLSWLARKKTGSDLKKAEKEDKNFKNEGLNPALPSSGSTEEKNESSPIY LASMLEHDYLVRKDKNSIQLGGVMIGLALNSVYYYREKTGDPQKEVEIKDSTLRQQGE KIAQEVINRLRKKDNLKNVPITVALYKQASKTSIVPGNFIAKTEVKAGSTDISNWDDI NEKYVFYPADTTTAEKYPDDTEVFKRFKNSIEEYFPNYTGVVGTALYENDEMKKMKID IPMQFYGKSEVVAFTQFLTGEVMDYYSKSSVDVEVNITSSDGQEAVIIRNAGDKEPTV HIYD*" gene 723635..724825 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" misc_feature complement(723830..723834) /Source="Nicolas_upshift_promotors" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(723834) /Source="Nicolas_upshifts" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 724862..724881 /Source="Nicolas_upshift_promotors" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 724870..724986 /Source="Nicolas_S_feature" /locus_tag="new_724870_724986" /HighExp="LoTm, B60, Lbstat, B36, BI, M9-stat, T1.30H, ferm, T3.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S234" upshifts 724870 /Source="Nicolas_upshifts" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" downshifts complement(724934) /Source="Nicolas_upshifts" /id="D327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="1.21197" /MaxDrop="3.77048" /score="18.5253059" /energy="-17.7" /TU="NA" /idTUdmin="U511" /TUdmin=1122 /isTUend="FALSE" CDS 724987..725997 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase" /protein_id="NP_388546.1" /db_xref="EnsemblGenomes-Gn:BSU06640" /db_xref="EnsemblGenomes-Tr:CAB12484" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG12837" /db_xref="UniProtKB/Swiss-Prot:O34640" /translation="MLDVHKDIKKIFHEEQVLAEAAARYGFSKDQVRFLADAENYVYE CMKDNQPYILKITHTIRRSSDYMMGEMEWLRHLAIGGISVAKPLPSLNGKDVEAVPDG NGGSFLLRVYEKAPGQKVDESDWNETLFYELGRYTGSMHSLTKSYKLSNPAFKRQEWD EEEQLKLRKYVPEDQIKVFQQADSLMNELRRLPKSQDNYGLVHADLHHGNFNWDHGKI TAFDFDDIGYNWFVNDISILLYNVLWYPVVPYDDKAAFTEEFMTHFMKGYWEENELDP AWLMIIPDFLRLRHMLIYGLLHQMFDLNTIGEEEKEMLAGFRRDIENGTPITAFDFSA LV*" gene 724987..725997 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" promotor_no_box complement(725004..725104) /Source="Nicolas_upshift_promotors" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(725044) /Source="Nicolas_upshifts" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 725980 /Source="Nicolas_upshifts" /id="D328" /incds=0 /nref=137 /ntot=253 /MaxReadThrough="3.07041" /MaxDrop="5.10987" /score="12.7441524" /energy="-17" /TU="NA" /idTUdmin="U507" /TUdmin=0 /isTUend="TRUE" S_feature 726024..726828 /Source="Nicolas_S_feature" /locus_tag="new_726024_726828" /HighExp="B60, B36, LoTm, M9-stat, Cold, T1.30H, T0.30H, ferm, Lbstat, LBGstat" /AntisenseName="sapB" /AntisenseCor="-0.57665624439942198" /AntisenseRegPval="-24.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S235" CDS complement(726035..726733) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 410907, 9043134, 14708580, 27350030, 28181542; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative magnesium transporter" /protein_id="NP_388547.1" /db_xref="EnsemblGenomes-Gn:BSU06650" /db_xref="EnsemblGenomes-Tr:CAB12485" /db_xref="GOA:Q45514" /db_xref="InterPro:IPR003416" /db_xref="SubtiList:BG11845" /db_xref="UniProtKB/Swiss-Prot:Q45514" /translation="MLLSWYIDPDILLKLGIATLIGMVIGLERELKNKPLGLKTCIVI AVSSCMLTIVSINAAYHFPKYYRIMMDPLRLPAQIISGVGFIGAGVILRKSNDVISGL TTSAMIWGAAGLGLATGAGFYKEAFASLLFILISVEFLPWVVRKIGPDRLQEKDIRIR MSLSDKDKMTEILKEMKRRDIKAHSVRIDDLGEKDFPIMEVKVRVHKNRYTTDVYYDI KAIEGVVGVKCDTL*" gene complement(726035..726733) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" downshifts complement(726056) /Source="Nicolas_upshifts" /id="D329" /incds=0 /nref=26 /ntot=129 /MaxReadThrough="2.5379" /MaxDrop="3.83708" /score="20.8493264" /energy="-16.2" /TU="NA" /idTUdmin="U511" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(726753..726771) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(726774) /Source="Nicolas_upshifts" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" promotor_-35 complement(726787..726792) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(726840..728318) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline transporter" /protein_id="NP_388548.1" /db_xref="EnsemblGenomes-Gn:BSU06660" /db_xref="EnsemblGenomes-Tr:CAB12486" /db_xref="GOA:O06493" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12641" /db_xref="UniProtKB/Swiss-Prot:O06493" /translation="MSIEIIISLGIYFIAMLLIGWYAFKKTTDINDYMLGGRGLGPFV TALSAGAADMSGWMLMGVPGAMFATGLSTLWLALGLTIGAYSNYLLLAPRLRAYTEAA DDAITIPDFFDKRFQHSSSLLKIVSALIIMIFFTLYTSSGMVSGGRLFESAFGADYKL GLFLTTAVVVLYTLFGGFLAVSLTDFVQGAIMFAALVLVPIVAFTHVGGVAPTFHEID AVNPHLLDIFKGASVISIISYLAWGLGYYGQPHIIVRFMAIKDIKDLKPARRIGMSWM IITVLGSVLTGLIGVAYAHKFGVAVKDPEMIFIIFSKILFHPLITGFLLSAILAAIMS SISSQLLVTASAVTEDLYRSFFRRKASDKELVMIGRLSVLVIAVIAVLLSLNPNSTIL DLVGYAWAGFGSAFGPAILLSLYWKRMNEWGALAAMIVGAATVLIWITTGLAKSTGVY EIIPGFILSMIAGIIVSMITKRPAKASYRLFGVMEKLLKRKK*" gene complement(726840..728318) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" downshifts complement(726854) /Source="Nicolas_upshifts" /id="D330" /incds=0 /nref=43 /ntot=142 /MaxReadThrough="5.35634" /MaxDrop="4.34381" /score="9.43100511" /energy="-13.8" /TU="U512,U513" /idTUdmin="U511" /TUdmin="-798" /isTUend="FALSE" upshifts complement(727706) /Source="Nicolas_upshifts" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" misc_feature complement(727709..727722) /Source="Nicolas_upshift_promotors" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(728319..728449) /Source="Nicolas_S_feature" /locus_tag="new_728319_728449_c" /HighExp="Salt, HiOs, Etha, Gly, MG 25, MG 45, M9-exp, MG t5, MG 15, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.954" /TUlongSig="NA" /TUlongPSig="NA" /label="S236" promotor_-10 complement(728440..728458) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(728449) /Source="Nicolas_upshifts" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" promotor_-35 complement(728473..728479) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 728580..728583 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 728598..728731 /Source="Nicolas_S_feature" /locus_tag="new_728598_728731" /HighExp="G180, G150, LBGexp, Oxctl, Paraq, dia0, G135, Lbexp, H2O2, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S237" upshifts 728598 /Source="Nicolas_upshifts" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" promotor_-10 728600..728619 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 728732..729022 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9342321, 11445070, 12682299, 25005615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9342321, 11445070, 12682299, 25005615; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit C)" /protein_id="NP_388549.1" /db_xref="EnsemblGenomes-Gn:BSU06670" /db_xref="EnsemblGenomes-Tr:CAB12487" /db_xref="GOA:O06492" /db_xref="InterPro:IPR003837" /db_xref="InterPro:IPR036113" /db_xref="SubtiList:BG12838" /db_xref="UniProtKB/Swiss-Prot:O06492" /translation="MSRISIEEVKHVAHLARLAITEEEAKMFTEQLDSIISFAEELNE VNTDNVEPTTHVLKMKNVMREDEAGKGLPVEDVMKNAPDHKDGYIRVPSILD*" gene 728732..729022 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" CDS 729038..730495 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit A)" /protein_id="NP_388550.1" /db_xref="EnsemblGenomes-Gn:BSU06680" /db_xref="EnsemblGenomes-Tr:CAB12488" /db_xref="GOA:O06491" /db_xref="InterPro:IPR000120" /db_xref="InterPro:IPR004412" /db_xref="InterPro:IPR020556" /db_xref="InterPro:IPR023631" /db_xref="InterPro:IPR036928" /db_xref="SubtiList:BG12839" /db_xref="UniProtKB/Swiss-Prot:O06491" /translation="MSLFDHKITELKQLIHKKEIKISDLVDESYKRIQAVDDKVQAFL ALDEERARAYAKELDEAVDGRSEHGLLFGMPIGVKDNIVTKGLRTTCSSKILENFDPI YDATVVQRLQDAEAVTIGKLNMDEFAMGSSTENSAYKLTKNPWNLDTVPGGSSGGSAA AVAAGEVPFSLGSDTGGSIRQPASFCGVVGLKPTYGRVSRYGLVAFASSLDQIGPITR TVEDNAFLLQAISGVDKMDSTSANVDVPDFLSSLTGDIKGLKIAVPKEYLGEGVGKEA RESVLAALKVLEGLGATWEEVSLPHSKYALATYYLLSSSEASANLARFDGIRYGYRTD NADNLIDLYKQTRAEGFGNEVKRRIMLGTFALSSGYYDAYYKKAQKVRTLIKKDFEDV FEKYDVIVGPTTPTPAFKIGENTKDPLTMYANDILTIPVNLAGVPGISVPCGLADGLP LGLQIIGKHFDESTVYRVAHAFEQATDHHKAKPEL*" gene 729038..730495 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" CDS 730509..731939 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit B)" /protein_id="NP_388551.2" /db_xref="EnsemblGenomes-Gn:BSU06690" /db_xref="EnsemblGenomes-Tr:CAB12489" /db_xref="GOA:O30509" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR004413" /db_xref="InterPro:IPR006075" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR017958" /db_xref="InterPro:IPR017959" /db_xref="InterPro:IPR018027" /db_xref="InterPro:IPR023168" /db_xref="SubtiList:BG12840" /db_xref="UniProtKB/Swiss-Prot:O30509" /translation="MNFETVIGLEVHVELKTKSKIFSSSPTPFGAEANTQTSVIDLGY PGVLPVLNKEAVEFAMKAAMALNCEIATDTKFDRKNYFYPDNPKAYQISQFDKPIGEN GWIEIEVGGKTKRIGITRLHLEEDAGKLTHTGDGYSLVDFNRQGTPLVEIVSEPDIRT PEEAYAYLEKLKSIIQYTGVSDCKMEEGSLRCDANISLRPIGQEEFGTKTELKNLNSF AFVQKGLEHEEKRQEQVLLSGGVIQQETRRYDEATKKTILMRVKEGSDDYRYFPEPDL VELYIDDEWKERVKASIPELPDERRKRYIEELGLPAYDAMVLTLTKEMADFFEETVQK GAEAKQASNWLMGEVSAYLNAEQKELADVALTPEGLAGMIKLIEKGTISSKIAKKVFK ELIEKGGDAEKIVKEKGLVQISDEGVLLKLVTEALDNNPQSIEDFKNGKDRAIGFLVG QIMKASKGQANPPMVNKILLEEIKKR*" gene 730509..731939 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" downshifts 731920 /Source="Nicolas_upshifts" /id="D331" /incds=0 /nref=257 /ntot=266 /MaxReadThrough="1.62334" /MaxDrop="8.77378" /score="26.1218607" /energy="-9.6" /TU="NA" /idTUdmin="U514" /TUdmin=0 /isTUend="TRUE" CDS complement(731954..732823) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388552.1" /db_xref="EnsemblGenomes-Gn:BSU06700" /db_xref="EnsemblGenomes-Tr:CAB12490" /db_xref="GOA:O31500" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG12841" /db_xref="UniProtKB/Swiss-Prot:O31500" /translation="MNEKKERIIKTSIRLFAKKGFAATTIQEIASECGISKGAFYLHF KSKEALLLSACEYYIGMSMNKMKNIEEDLAGKPPKEVLKKQIGAQFEDFRDHKDFIVL LLTENIIPENQEIKQYFYKVTMETDKLYRNALLVSYGEGIERYVADLSIMARGIVHSY MNVMVFNGELNIDAEEISAFIIERLDDLVQGLSRSALNPIVSKDIFNPMPAGKDQLLE DIQKVKENSTLPEDITVSLDVIEEELTQDKPRKPIIKGMLSNLAGTNDKEVERLRALI LSLSQFDHKKSSL*" gene complement(731954..732823) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" downshifts complement(731996) /Source="Nicolas_upshifts" /id="D332" /incds=0 /nref=122 /ntot=211 /MaxReadThrough="2.21801" /MaxDrop="4.89305" /score="32.2694333" /energy="-11.4" /TU="NA" /idTUdmin="U517" /TUdmin=0 /isTUend="TRUE" promotor_-35 732613..732618 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-35" promotor_-10 732634..732652 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-10" upshifts 732646 /Source="Nicolas_upshifts" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" S_feature complement(732824..732898) /Source="Nicolas_S_feature" /locus_tag="new_732824_732898_c" /HighExp="C30, S1, T3.0H, T4.0H, Salt, T5.0H, T2.0H, T3.30H, MG 150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S238" promotor_-35 732876..732883 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(732892..732911) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 732898 /Source="Nicolas_upshifts" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" promotor_-10 732899..732918 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(732905) /Source="Nicolas_upshifts" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" promotor_-35 complement(732926..732933) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-35" CDS 732955..736113 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11709341, 15066026, 15941986, 25366377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11709341, 15066026, 15941986, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter involved in surfactin self-resistance" /protein_id="NP_388553.2" /db_xref="EnsemblGenomes-Gn:BSU06710" /db_xref="EnsemblGenomes-Tr:CAB12491" /db_xref="GOA:O31501" /db_xref="InterPro:IPR001036" /db_xref="InterPro:IPR027463" /db_xref="SubtiList:BG12842" /db_xref="UniProtKB/Swiss-Prot:O31501" /translation="MNHVINFVLKNKFAVWLMTIIVTAAGLYAGMNMKQESIPDVNMP YLTISTTYPGATPSQVADEVTKPVEQAVQNLDGVSVVTSTSYENASSVMIEYDYEKDM DKAKTEAAEALENVNLPDDAKDPEISRYSLNSFPILTLSVSSDKDNLQELTKQVEDSL VSKLEGIEGVASVQVSGQQVEEVEFSFKEDKLKEYGLDEDTVKQVIQGSDVTTPLGLY TFGNEEKSVVVSGDIETIKDLKNMRIPTASASSAGSSAASQAGAQSAQAAQSAQAAAQ VQQSASTAVPTVKLSDIATIKDVKKAESVSRTNGKDSIGINIVKANDANTVEVADDVK AELKKFKEDHKGFNYSATLDMAEPITQSVDTMLSKAIFGAIFAIVIILLFLRDIKSTL ISVVSIPLSLLIALLVLQQLDITLNIMTLGAMTVAIGRVVDDSIVVIENIYRRMRLKD EPLRGKALVREATKEMFKPIMSSTIVTIAVFLPLALVGGQIGELFIPFALTIVFALAA SLVISITLVPMLAHSLFKKSLTGAPIKAKEHKPGRLANIYKKVLNWALSHKWITSIIA VLMLLGSLFLVPLIGASYLPSEEEKTMQLTYSPEPGETKKEAENEAEKAEKILLDRKH VDTVQYSLGSGSPLAGGDSNGALFYIKYESDTPDFDKEKDNVLKEIQKQSDRGEWKSQ DFSSSGNNNELTYYVYGDSENDIKDTVKDIEKIMKDEKDLKNVNSGLSSTYDEYTFVA DQEKLSKLGLTASQISQALMSQTSQEPLTTVKKDGKELDVNIKTEKDEYKSVKDLENK KITSATGQEVKIGDVAKVKEGSTSDTVSKRDGKVYADVTGEVTSDNVTAVSAAIQKKI DKLDHPDNVSIDTGGVSADIADSFTKLGLAMLAAIAIVYLVLVITFGGALAPFAILFS LPFTVIGALVGLYVSGETISLNAMIGMLMLIGIVVTNAIVLIDRVIHKEAEGLSTREA LLEAGSTRLRPILMTAIATIGALIPLALGFEGGSQVISKGLGVTVIGGLISSTLLTLL IVPIVYEVLAKFRKKKPGTEEE*" gene 732955..736113 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" downshifts 736100 /Source="Nicolas_upshifts" /id="D333" /incds=0 /nref=76 /ntot=243 /MaxReadThrough="3.70478" /MaxDrop="4.6624" /score="-3.65521193" /energy="-12.7" /TU="U516" /idTUdmin="U516" /TUdmin="-110" /isTUend="FALSE" promotor_-35 736352..736355 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 736370..736389 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 736378 /Source="Nicolas_upshifts" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" CDS 736436..737347 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" /EC_number="2.7.1.107" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12682299, 17535816, 22224599, 24700682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12682299, 17535816, 22224599, 24700682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diacylglycerol kinase" /protein_id="NP_388554.1" /db_xref="EnsemblGenomes-Gn:BSU06720" /db_xref="EnsemblGenomes-Tr:CAB12492" /db_xref="GOA:O31502" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG12843" /db_xref="UniProtKB/Swiss-Prot:O31502" /translation="MKRARIIYNPTSGREIFKKHLAQVLQKFEQAGYETSTHATTCAG DATHAAKEAALREFDLIIAAGGDGTINEVVNGLAPLDNRPTLGVIPVGTTNDFARALG IPREDILKAADTVINGVARPIDIGQVNGQYFINIAGGGRLTELTYDVPSKLKTMLGQL AYYLKGMEMLPSLRPTEVEIEYDGKLFQGEIMLFLVTLTNSVGGFEKLAPDSSLNDGM FDLMILKKANLAEFIRVATMALRGEHINDQHIIYTKANRVKVNVSEKMQLNLDGEYGG MLPGEFVNLYRHIHVVMPKEKAEQLDD*" gene 736436..737347 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" S_feature 737348..737602 /Source="Nicolas_S_feature" /locus_tag="new_737348_737602" /HighExp="H2O2, Oxctl, Paraq, G180, Cold, C30, G150, G135, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S239" CDS 737603..738982 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" /EC_number="2.1.1.189" /EC_number="2.1.1.190" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21824914" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21824914; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyltransferase of m5U747 and m5U1939 in 23S RNA" /protein_id="NP_388555.1" /db_xref="EnsemblGenomes-Gn:BSU06730" /db_xref="EnsemblGenomes-Tr:CAB12493" /db_xref="GOA:O31503" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12826" /db_xref="UniProtKB/Swiss-Prot:O31503" /translation="MKMKPPVEKNEYYDVTFEDLTHEGAGVAKVQGFPIFVPNALPEE KAQIKVTRVKKGFAFGRLIELKEESPHRTDAPCPIYKQCGGCQLQHMTYEGQLLFKQK QVKDVLERIGKLDLSKVTVHPTLGMEDPWNYRNKAQVPVGEREGGLVAGFYQQRSHDI IDMSACLIQQSKNDEAVQAVKDICANYGVKAYNEERHKGWLRHIMVRYGVVTGEMMIV FITRTSDFPHKAKIIEDITAQFPHVKSIVQNINPNKTNVIFGNETNVIWGEEYIYDLI GDVKFAISARSFYQVNPEQTKVLYDKALEYAELQGEETVIDAYCGIGTISLFLAKQAK KVYGVEIVPEAIEDAKRNAELNGNTNAEFAVGEAETVIPKWYEEGITADTLVVDPPRK GCDEALLRTIVEMKPKRVVYVSCNPGTLARDLRVLEDGGYVTREVQPVDMFPHTNHVE CCVLIKLKE*" gene 737603..738982 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" S_feature 738983..739575 /Source="Nicolas_S_feature" /locus_tag="new_738983_739575" /HighExp="Cold, H2O2, G135, G150, Oxctl, G180, C30, Paraq, LPh, HPh" /AntisenseName="yefB" /AntisenseCor="0.24913678485492899" /AntisenseRegPval="-4.4000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S240" CDS complement(738995..739897) /gene="yefB" /locus_tag="BSU_06740" /old_locus_tag="BSU06740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1779754, 1762151; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase / invertase; HGT island" /protein_id="NP_388556.1" /db_xref="EnsemblGenomes-Gn:BSU06740" /db_xref="EnsemblGenomes-Tr:CAB12494" /db_xref="GOA:O34574" /db_xref="InterPro:IPR011109" /db_xref="InterPro:IPR025827" /db_xref="SubtiList:BG12827" /db_xref="UniProtKB/Swiss-Prot:O34574" /translation="MYNEGVTSPSQLARKKNATDKWHGSSIRKILENPHYTGTLQQCR EYRPSVTSKRRRSVNLENQIIIEKSHEPIIPLEDFLIVQEILITRKRRRPQAEVHLFT NTAVCKDCRRSMHFKKNRKGYVCGSYNKHGLKACSDHYVSEIDLTDKVITNLNKIYLK FSKENYFKELSEKALKYKEKIESKIIEINEKLNDKKRDKSNLVISLANGVISKEDYQL AINITNEDISNFETTLHQLSKDLEFQKIEKEIIDFKKSLDKFMKEGTLTPEMLHLLVD EIEVHANGTIEINYRFREPTVPSA*" gene complement(738995..739897) /gene="yefB" /locus_tag="BSU_06740" /old_locus_tag="BSU06740" downshifts 739532 /Source="Nicolas_upshifts" /id="D334" /incds=1 /nref=1 /ntot=30 /MaxReadThrough="4.70474" /MaxDrop="2.82299" /score="-8.81916201" /energy="-8.8" /TU="U518" /idTUdmin="U516" /TUdmin=3322 /isTUend="FALSE" S_feature 739577..739877 /Source="Nicolas_S_feature" /locus_tag="new_739577_739877" /HighExp="H2O2, Cold, G180, G135, G150, Paraq, Oxctl, C30, LPh, LBGexp" /AntisenseName="yefB" /AntisenseCor="0.202214664414261" /AntisenseRegPval="-3.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S241" CDS 739878..740213 /gene="yefC" /locus_tag="BSU_06750" /old_locus_tag="BSU06750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative resolvase; HGT island" /protein_id="NP_388557.2" /db_xref="EnsemblGenomes-Gn:BSU06750" /db_xref="EnsemblGenomes-Tr:CAB12495" /db_xref="GOA:O35034" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG12828" /db_xref="UniProtKB/Swiss-Prot:O35034" /translation="MTPSLYNPLAIASKPFPAIYSEKILIFTIFSAFAEFERDMIVER TQEGKMLAKQNPDFREGRPKKFTKQQINHALTLLENHSYKQVEDMTGISVSTLVRAKK KKAAEAING*" gene 739878..740213 /gene="yefC" /locus_tag="BSU_06750" /old_locus_tag="BSU06750" S_feature 740214..740287 /Source="Nicolas_S_feature" /locus_tag="new_740214_740287" /HighExp="G180, H2O2, G150, Cold, G135, Paraq, Oxctl, C30, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S242" CDS 740288..742927 /gene="yeeA" /locus_tag="BSU_06760" /old_locus_tag="BSU06760" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative restriction type II methylase; HGT island" /protein_id="NP_388558.1" /db_xref="EnsemblGenomes-Gn:BSU06760" /db_xref="EnsemblGenomes-Tr:CAB12496" /db_xref="GOA:O31504" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12818" /db_xref="UniProtKB/Swiss-Prot:O31504" /translation="MALIDLEDKIAEIVNREDHSDFLYELLGVYDVPRATITRLKKGN QNLTKRVGEVHLKNKVWFKEAKKGKLFDALIDIEQQVEYLSAKPRYLLVTDYDGVLAK DTKTLEALDVKFEELPQYFDFFLAWKGIEKVEFEKENPADIKAAERFARIYDVLRKEN NIIETNRGLDLFLIRLLFCFFAEDTDIFKRNSFTNLIKTLTEEDGSNLNKLFADLFIV LDKNERDDVPSYLKEFPYVNGQLFTEPHTELEFSAKSRKLIIECGELLNWAKINPDIF GSMIQAVASEESRSYLGMHYTSVPNIMKVIKPLFLDKLNQSFLDAYDDYTKLENLLTR IGKIKFFDPACGSGNFLIITYKELRRMEINIIKRLQELLGEYLYVPSVTLSQFYGIEI EDFAHDVAKLSLWIAEHQMNEELKNEVHNAVRPTLPLHTAGDIRCANAIRVEWTEVCP AQGSEEVYVFGNPPYLGSKKQNKEHKSDMLSIFGKVKNGKMLDYISAWFYFGAKYAST TNAKVAFVSTNSVTQGEQVSILWNELFKFGIQINFAYKSFKWANNAKNNAAVIVVIVG FGPLDTKVNKYLFVDETKKLVSNISPYLTDGENILVSSRTKPISDLPKLHFGNMPNDG GGLLFTITEYTDAINKYPELVPYFKKFIGSVEFINGGLRYCLWLNEAKYEKIKSNPLI QERISISKNHREKSTDKGTNKLALTPWKFRDTHETTNYSIVVPSVSSENRFYIPMGLA GADTILSNLIYVIYDAEIYLLGILMSRMHMTWVKAVAGRLKTDYRYSAGLCYNTFPIP ELSTRRKNEIEEAILEILDLREEQGGTLAELYNPSTMPIELKVAHEKLDGIVERAYRQ KQFESDEERLEVLLKLYQEMTER*" gene 740288..742927 /gene="yeeA" /locus_tag="BSU_06760" /old_locus_tag="BSU06760" CDS 742939..744738 /gene="yeeB" /locus_tag="BSU_06770" /old_locus_tag="BSU06770" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA helicase / endonuclease; HGT island" /protein_id="NP_388559.2" /db_xref="EnsemblGenomes-Gn:BSU06770" /db_xref="EnsemblGenomes-Tr:CAB12497" /db_xref="GOA:O34469" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12819" /db_xref="UniProtKB/Swiss-Prot:O34469" /translation="MENIIEINYNQTGKSKKTNEYGMREMQARAFEKRNSQYLLVKAP PASGKSRALMFIGLDKLINQGLRKVIVAVPERSIGSSFKNTDLKSYGFFENWKVDPRN NLTVGGDNSKVKSFVRFMESDDQVLICTHSTLRFAFEKIDDKAFDNCLLAIDEFHHVS ADVNSRLGELLRSIIHNSSAHIVAMTGSYFRGDSVPILLPEDEELFDKVTYSYYEQLD GYEYLKGFGIGYHFYQGQYTSAINEVLDTNKKTIVHIPNVNSGESTKDKYDEVGKILD MIGEVEYQDDDTGIIYVKRHSDGKTLKIADLVDDQVGRENVVAYLRNIEALDDLDIII ALGMAKEGFDWPFCEHTLTVGYRGSLTEIVQIIGRCTRDSYNKTYAQFTNLIAMPDAK DEVVTYTVNTMLKAISASLLMEQVLTPDFKFKRRRNESEKSSTTGELFVKGLKEPSTE NVKKIIENDINDLKAKIMQDSQVQKTFSGEVDPKVLNKVLIPKVIQKVYPNLSDEEIE EVRQHVVLDTVMKGAKSEVVGSKEFIRMADKFINIEDLDINLIDSINPFQKAFEVLSK ELNSPVLKLIQETIDAKRINFDEDELVFIWPKV*" gene 742939..744738 /gene="yeeB" /locus_tag="BSU_06770" /old_locus_tag="BSU06770" promotor_-10 complement(743179..743194) /Source="Nicolas_upshift_promotors" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(743194) /Source="Nicolas_upshifts" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(743206..743215) /Source="Nicolas_upshift_promotors" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 744739..744850 /Source="Nicolas_S_feature" /locus_tag="new_744739_744850" /HighExp="Cold, G180, G135, G150, H2O2, Paraq, HPh, LPh, Oxctl, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S243" CDS 744851..745999 /gene="yeeC" /locus_tag="BSU_06780" /old_locus_tag="BSU06780" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="NP_388560.2" /db_xref="EnsemblGenomes-Gn:BSU06780" /db_xref="EnsemblGenomes-Tr:CAB12498" /db_xref="InterPro:IPR018306" /db_xref="SubtiList:BG12820" /db_xref="UniProtKB/Swiss-Prot:O34352" /translation="MASNRYHSINEIMESQLFYQITTPPKKTQKAQYDPEVEKFLEII EFVKENGREPQKVPTDLTERSLASRLIGIRKDPDRMEYLKEYDEIGLLEVRSKELTIP KISSIDDILKSGLSALLGDNLNNDITRSIFDTSSLQKVTTMPEYVAKRKKIKDFGKFE ELFKKCHKEITEGKRKILTFKNEQDIQSNSFYILKGVLLYVEDVGERKKAKGKTNARL RCIFENGTESDMLLRSLSAELYKHGRRVTDNEDTLLDNVREDDVSTGFIYVLKSLSTD PQISSIKNLYKIGFTTGSVENRIRNAENQSTYLYAPVEIVTTYQVFNMNASKFETAIH HALANNNLDVSILGANGKMLVPKEWFVVTLEDLQAVIDEIVMMVHLYD*" gene 744851..745999 /gene="yeeC" /locus_tag="BSU_06780" /old_locus_tag="BSU06780" S_feature 746000..747189 /Source="Nicolas_S_feature" /locus_tag="new_746000_747189" /HighExp="Cold, G135, H2O2, G180, G150, LPh, C30, HPh, BMM, Paraq" /AntisenseName="yeeD" /AntisenseCor="-0.41772847620445203" /AntisenseRegPval="-12.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S244" CDS complement(746261..746566) /gene="yeeD" /locus_tag="BSU_06790" /old_locus_tag="BSU06790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="NP_388561.1" /db_xref="EnsemblGenomes-Gn:BSU06790" /db_xref="EnsemblGenomes-Tr:CAB12499" /db_xref="SubtiList:BG12821" /db_xref="UniProtKB/Swiss-Prot:O34950" /translation="MTVRKELIKQINLTITVIKTINQKNPTPMVKNILKRYEEAKEFI LQSSDGKFEEDLSKVRNKLDTLTRAYLESANDYMNPMLKEMHKTEKLLKEYDETTQS* " gene complement(746261..746566) /gene="yeeD" /locus_tag="BSU_06790" /old_locus_tag="BSU06790" CDS complement(746633..746839) /gene="yezA" /locus_tag="BSU_06800" /old_locus_tag="BSU06800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="hypothetical protein; HGT island" /protein_id="NP_388562.1" /db_xref="EnsemblGenomes-Gn:BSU06800" /db_xref="EnsemblGenomes-Tr:CAB12500" /db_xref="GOA:O31505" /db_xref="InterPro:IPR000290" /db_xref="InterPro:IPR035900" /db_xref="SubtiList:BG12872" /db_xref="UniProtKB/Swiss-Prot:O31505" /translation="MDKLTKEELIFLVKELMNPTLDDEKVSEYLDLLEKNVPYPAPSD LIFWSNEDYTAEQVVKIALNYKDE*" gene complement(746633..746839) /gene="yezA" /locus_tag="BSU_06800" /old_locus_tag="BSU06800" CDS complement(747079..747534) /gene="yezG" /locus_tag="BSU_06811" /old_locus_tag="BSU06811" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="YP_003097692.1" /db_xref="EnsemblGenomes-Gn:BSU06811" /db_xref="EnsemblGenomes-Tr:CAX52579" /db_xref="InterPro:IPR006728" /db_xref="InterPro:IPR036170" /db_xref="UniProtKB/Swiss-Prot:C0H3X4" /translation="MQDLYQLIGEKLNDIIPGEWTKIYLYAEVLDDSTMVLFHFRTPE NNQIIYSQDIPSHYNVSKDIFKTLLRELRELFEELRTEHRNNNDDVWTNLTLTLDRSG EFQLDYNYDDILASELDGYERIAIWEYKNLGILPEDEDDKEFVISYLGL*" gene complement(747079..747534) /gene="yezG" /locus_tag="BSU_06811" /old_locus_tag="BSU06811" downshifts complement(747092) /Source="Nicolas_upshifts" /id="D335" /incds=0 /nref=41 /ntot=213 /MaxReadThrough="4.42275" /MaxDrop="5.23695" /score="10.2582155" /energy="-11.7" /TU="U520,U521" /idTUdmin="U520" /TUdmin="-529" /isTUend="FALSE" CDS complement(747554..749563) /gene="yeeF" /locus_tag="BSU_06812" /old_locus_tag="BSU06812" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein; HGT island" /protein_id="NP_388563.2" /db_xref="EnsemblGenomes-Gn:BSU06812" /db_xref="EnsemblGenomes-Tr:CAB12501" /db_xref="GOA:O31506" /db_xref="InterPro:IPR006829" /db_xref="SubtiList:BG12822" /db_xref="UniProtKB/Swiss-Prot:O31506" /translation="MKVFEAKTLLSEATDRAKEYKELRTQMVNLRKALKGVADLSDSE FSGKGASNIKAFYHDHVGVADQWIDYIDMKIAFFNSIAGAAEDKGLSDAYIEESFLEH ELANANKKSKSIMSEQKKAMKDILNDIDDILPLDLFSTETFKDELADANDKRKKTLEK LDALDEDLKTEYALSEPNEQFIKSDFQKLQEATGKGKNATPIHYNAKAYRESDIHKKK GDIEKRTEAYLKIKKEEAKEREIEKLKERLKNYDYADADEFYEMAKTIGYENLTAEQQ RYFTQIENTRELEAGFKGVAVGLYDSGKDAVVGLWDMVTDPGGTVEAITGAMAHPIKT YEAISAAIEESYQKDMVNGDTYSRARWVSYAVGTVVTSIVGTKGVGAVSKTGTAAKVT TKVKTAASKSATAQKAITVSKQTVDHIKQKVNTGIEVSKKHVKTKLNQIGDLTLADIL PYHPRHDLVPAGVPYNAVNGVTLKEGLQKFAKVILPKPYGTSSSGRRTPAPHVPPVTV KYGEHFARWSRKKVLKPNIIYKTKEGYTYTTDNYGRITSVKADLQLGEAKRNQYAQTN AGKPQDRKPDDDGGHLIATQFKGSGQFDNIVPMNSQINRSGGKWYEMEQEWAKALSKK PPKKVAVQIEPVYSGDSLRPSYFDVTYKIGSRKEISVSIKNQPGG*" gene complement(747554..749563) /gene="yeeF" /locus_tag="BSU_06812" /old_locus_tag="BSU06812" promotor_-10 complement(747921..747940) /Source="Nicolas_upshift_promotors" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(747928) /Source="Nicolas_upshifts" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" promotor_-35 complement(747953..747958) /Source="Nicolas_upshift_promotors" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(749590..749609) /Source="Nicolas_upshift_promotors" /id="U521" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig="0.994005994005994" /xcortree=2985 /SigmaFactorBS="atgactcatttttccaccaaaacacgttctcacccccacctt atcccgaccCGTGGTAAAATTTTGATATTgagcgaacaaaagaagggaaatggtcatg a" /listShort="yeeF, yezG, yezA, yeeD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(749600) /Source="Nicolas_upshifts" /id="U521" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig="0.994005994005994" /xcortree=2985 /SigmaFactorBS="atgactcatttttccaccaaaacacgttctcacccccacctt atcccgaccCGTGGTAAAATTTTGATATTgagcgaacaaaagaagggaaatggtcatg a" /listShort="yeeF, yezG, yezA, yeeD" /GFF_Attribute="listLong" CDS 749775..750797 /gene="yeeG" /locus_tag="BSU_06820" /old_locus_tag="BSU06820" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative phage receptor protein" /protein_id="NP_388564.2" /db_xref="EnsemblGenomes-Gn:BSU06820" /db_xref="EnsemblGenomes-Tr:CAB12502" /db_xref="GOA:O31507" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12823" /db_xref="UniProtKB/Swiss-Prot:O31507" /translation="MTKKRITFGLLVLMVCVILFVLYVQLRNKDSIPVQSSAIHPEED RIFFIYSNPFIKESVLLSTSTGERFNRRTFKVADVPYIQTKSYASTDLVLLAEHEPFY YTLEKDVIKEHPLSDPFAFWYEGKDVTIEAYNVDTTGNEIHINDRKTKKEYTLTLPPL VTMGASDENFIYIIQSMSIYVIDRKTEEMIETLSLASYADQFADSEEFIVASSDHKLT VIEKGTWKTTYIAYPEDLEYADTVYYDKESGSFYVAYEDKEGGANLLEYGEDFSIHTY SLKFPYMEAKFKGNLLYIVAQEEHKKGIGGYVGVFDIHSKEMLYQFDLPEEQVKVQDF VVVDNK*" gene 749775..750797 /gene="yeeG" /locus_tag="BSU_06820" /old_locus_tag="BSU06820" promotor_-35 750897..750904 /Source="Nicolas_upshift_promotors" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="promotor_-35" promotor_-10 750918..750937 /Source="Nicolas_upshift_promotors" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="promotor_-10" upshifts 750919 /Source="Nicolas_upshifts" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" CDS 750959..752089 /gene="rapH" /locus_tag="BSU_06830" /old_locus_tag="BSU06830" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16553878, 21908671" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 21908671; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388565.2" /db_xref="EnsemblGenomes-Gn:BSU06830" /db_xref="EnsemblGenomes-Tr:CAB12503" /db_xref="GOA:Q59HN8" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:3Q15" /db_xref="SubtiList:BG11031" /db_xref="UniProtKB/Swiss-Prot:Q59HN8" /translation="MSQAIPSSRVGVKINEWYKMIRQFSVPDAEILKAEVEQDIQQME EDQDLLIYYSLMCFRHQLMLDYLEPGKTYGNRPTVTELLETIETPQKKLTGLLKYYSL FFRGMYEFDQKEYVEAIGYYREAEKELPFVSDDIEKAEFHFKVAEAYYHMKQTHVSMY HILQALDIYQNHPLYSIRTIQSLFVIAGNYDDFKHYDKALPHLEAALELAMDIQNDRF IAISLLNIANSYDRSGDDQMAVEHFQKAAKVSREKVPDLLPKVLFGLSWTLCKAGQTQ KAFQFIEEGLDHITARSHKFYKELFLFLQAVYKETVDERKIHDLLSYFEKKNLHAYIE ACARSAAAVFESSCHFEQAAAFYRKVLKAQEDILKGECLYAY*" gene 750959..752089 /gene="rapH" /locus_tag="BSU_06830" /old_locus_tag="BSU06830" CDS 752079..752252 /gene="phrH" /locus_tag="BSU_06839" /old_locus_tag="BSU06839" /experiment="publication(s) with functional evidences, PMID:16553878, 21908671" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 21908671; Product type r: regulator" /codon_start=1 /transl_table=11 /product="hexapeptide (TDRNTT) inhibitor of regulatory cascade" /protein_id="YP_003097693.1" /db_xref="EnsemblGenomes-Gn:BSU06839" /db_xref="EnsemblGenomes-Tr:CAX52580" /db_xref="GOA:Q59HN7" /db_xref="UniProtKB/Swiss-Prot:Q59HN7" /translation="MPIKKKVMMCLAVTLVFGSMSFPTLTNSGGFKESTDRNTTYIDH SPYKLSDQKKALS*" gene 752079..752252 /gene="phrH" /locus_tag="BSU_06839" /old_locus_tag="BSU06839" downshifts 752207 /Source="Nicolas_upshifts" /id="D336" /incds=0 /nref=3 /ntot=66 /MaxReadThrough="5.5891" /MaxDrop="2.9063" /score="14.5772672" /energy="-7.6" /TU="U522" /idTUdmin="U522" /TUdmin="-901" /isTUend="FALSE" S_feature 752253..752357 /Source="Nicolas_S_feature" /locus_tag="new_752253_752357" /HighExp="S2, G/S, T2.30H, GM 150, T3.0H, T2.0H, S1, T-4.40H, T-2.40H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S245" promotor_-35 752324..752331 /Source="Nicolas_upshift_promotors" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 752346..752365 /Source="Nicolas_upshift_promotors" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 752359 /Source="Nicolas_upshifts" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" CDS 752412..753131 /gene="yeeI" /locus_tag="BSU_06840" /old_locus_tag="BSU06840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA integrase or transcriptional regulator" /protein_id="NP_388566.3" /db_xref="EnsemblGenomes-Gn:BSU06840" /db_xref="EnsemblGenomes-Tr:CAB12504" /db_xref="GOA:O31509" /db_xref="InterPro:IPR002876" /db_xref="InterPro:IPR017856" /db_xref="InterPro:IPR026562" /db_xref="InterPro:IPR026564" /db_xref="InterPro:IPR029072" /db_xref="SubtiList:BG12824" /db_xref="UniProtKB/Swiss-Prot:O31509" /translation="MGRKWNNIKEKKASKDANTSRIYAKFGREIYVAAKQGEPDPESN QALKVVLERAKTYSVPKNIIERAIEKAKGGAEENYDELRYEGFGPNGSMIIVDALTNN VNRTAPEVRAAFGKNGGNMGVSGSVAYMFDATAVIGVEGKTADEALEILMEADVDVRD ILEEDDSAIVYAEPDQFHAVQEAFKNAGVEEFTVAELTMLAQSEVTLPDDAKEQFEKL IDALEDLEDVQQVYHNVDLGE*" gene 752412..753131 /gene="yeeI" /locus_tag="BSU_06840" /old_locus_tag="BSU06840" downshifts complement(752414) /Source="Nicolas_upshifts" /id="D337" /incds=0 /nref=3 /ntot=70 /MaxReadThrough="1.42969" /MaxDrop="3.99424" /score="-5.23712559" /energy="-7.6" /TU="NA" /idTUdmin="U520" /TUdmin="-5851" /isTUend="FALSE" promotor_-35 752989..752996 /Source="Nicolas_upshift_promotors" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 753010..753029 /Source="Nicolas_upshift_promotors" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 753020 /Source="Nicolas_upshifts" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" downshifts 753113 /Source="Nicolas_upshifts" /id="D338" /incds=0 /nref=223 /ntot=271 /MaxReadThrough="4.94236" /MaxDrop="5.19148" /score="31.0415099" /energy="-11.4" /TU="U523,U524" /idTUdmin="U522" /TUdmin=5 /isTUend="TRUE" promotor_-35 753200..753209 /Source="Nicolas_upshift_promotors" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 753223..753242 /Source="Nicolas_upshift_promotors" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 753226 /Source="Nicolas_upshifts" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" promotor_-10 complement(753230..753248) /Source="Nicolas_upshift_promotors" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(753250) /Source="Nicolas_upshifts" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(753264..753269) /Source="Nicolas_upshift_promotors" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 753265..753702 /gene="cotK" /locus_tag="BSU_06850" /old_locus_tag="BSU06850" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 19060142, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 19060142, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore inner coat protein" /protein_id="NP_388567.2" /db_xref="EnsemblGenomes-Gn:BSU06850" /db_xref="EnsemblGenomes-Tr:CAB12505" /db_xref="GOA:O31510" /db_xref="SubtiList:BG12825" /db_xref="UniProtKB/Swiss-Prot:O31510" /translation="MTDTRHMYGGPGFGHYQGFGIGHPGYGMQSTGYPGYGMYGGHPG YGMQGYPDHGIHGGVGGYPGYGGYGGYPSGGYGGSPGTGSYPSMHHENDGHHHYYHHH HDGKDNLHHHHHHVGKDNHHHHHDGHYGHHHHHMGHWGKDGYK*" gene 753265..753702 /gene="cotK" /locus_tag="BSU_06850" /old_locus_tag="BSU06850" downshifts complement(753272) /Source="Nicolas_upshifts" /id="D339" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.62645" /MaxDrop="3.26146" /score="-5.23712559" /energy="-7.6" /TU="NA" /idTUdmin="U520" /TUdmin="-6709" /isTUend="FALSE" downshifts 753702 /Source="Nicolas_upshifts" /id="D340" /incds=0 /nref=82 /ntot=208 /MaxReadThrough="2.37564" /MaxDrop="8.21113" /score="17.7046271" /energy="-9" /TU="U525" /idTUdmin="U523" /TUdmin=0 /isTUend="TRUE" promotor_-35 753762..753769 /Source="Nicolas_upshift_promotors" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 753785..753804 /Source="Nicolas_upshift_promotors" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 753790 /Source="Nicolas_upshifts" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" CDS 753817..754401 /gene="yezE" /locus_tag="BSU_06860" /old_locus_tag="BSU06860" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR family)" /protein_id="YP_054572.1" /db_xref="EnsemblGenomes-Gn:BSU06860" /db_xref="EnsemblGenomes-Tr:CAE01448" /db_xref="GOA:Q7WY76" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG14194" /db_xref="UniProtKB/Swiss-Prot:Q7WY76" /translation="MGRNKEFDTALVLHRAIEVFGEYGYEGTSLQDLLSHLGIARQSL YDTYGTKRDLFLSAVKSYLEGKNAAVMERLEAPGSVKEAIRDIFQEGVNALRDPERAK ACYIINSAIEQIPHDPELARYFERQSKQLEDAFYHGLLRAKDQGELNGEDTDISALAR YLNQSRLSLTFIAKVTADMDRLQDHVDVSLSVLD*" gene 753817..754401 /gene="yezE" /locus_tag="BSU_06860" /old_locus_tag="BSU06860" downshifts 754382 /Source="Nicolas_upshifts" /id="D341" /incds=0 /nref=26 /ntot=216 /MaxReadThrough="2.43615" /MaxDrop="3.31193" /score="17.7046271" /energy="-9" /TU="NA" /idTUdmin="U527" /TUdmin="-2" /isTUend="TRUE" CDS 754480..754923 /gene="yesE" /locus_tag="BSU_06870" /old_locus_tag="BSU06870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388568.1" /db_xref="EnsemblGenomes-Gn:BSU06870" /db_xref="EnsemblGenomes-Tr:CAB12506" /db_xref="InterPro:IPR009959" /db_xref="InterPro:IPR032710" /db_xref="PDB:1S5A" /db_xref="SubtiList:BG12844" /db_xref="UniProtKB/Swiss-Prot:O31511" /translation="MLMNEFEKACETLRKFMAYMLEKDMKSWTELWDENAVFEFPYAP EGSPKRIEGKAAIYDYIKDYPKQIHLSSFTAPTVYRSADSNTVIAEFQCDGHVIETGL PYRQSYISVIETRDGRIVRYRDYWNPLVVKEAFGGSFLQTEESGK*" gene 754480..754923 /gene="yesE" /locus_tag="BSU_06870" /old_locus_tag="BSU06870" CDS 754920..755780 /gene="yesF" /locus_tag="BSU_06880" /old_locus_tag="BSU06880" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21494745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388569.1" /db_xref="EnsemblGenomes-Gn:BSU06880" /db_xref="EnsemblGenomes-Tr:CAB12507" /db_xref="GOA:O31512" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR008030" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11808" /db_xref="UniProtKB/Swiss-Prot:O31512" /translation="MMKQNPILITGGTGTVGSRIASRLIKLGYRVRIASRKKGALADA EYVYFNWKYASSFTPALEQVKQIYLVAPVGVFDPAPYVLPFLKEAKRLGAKRVVMQSA SVVSENGPVFGALHQAVREFPEWTVLRPSYFMQNFINVQHRMSIQTEGRITTASGEGK LGFIDADDIAETAVRALIDDVPHQTHHILTGPEALSYAEAAEIIGAAAGRRVEHVSIS RSELQHKMEAGGLPADYAHFMAKLDEAISHGAEHRVTDTVKRVTGKEPRSLSEFAAAH AAYWTSFWTE*" gene 754920..755780 /gene="yesF" /locus_tag="BSU_06880" /old_locus_tag="BSU06880" promotor_-35 755842..755847 /Source="Nicolas_upshift_promotors" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 755863..755881 /Source="Nicolas_upshift_promotors" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 755863 /Source="Nicolas_upshifts" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" promotor_-10 complement(755885..755899) /Source="Nicolas_upshift_promotors" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(755890) /Source="Nicolas_upshifts" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(755907..755911) /Source="Nicolas_upshift_promotors" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 755907..756155 /gene="cotJA" /locus_tag="BSU_06890" /old_locus_tag="BSU06890" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the inner spore coat" /protein_id="NP_388570.1" /db_xref="EnsemblGenomes-Gn:BSU06890" /db_xref="EnsemblGenomes-Tr:CAB12508" /db_xref="InterPro:IPR020256" /db_xref="SubtiList:BG11799" /db_xref="UniProtKB/Swiss-Prot:Q45536" /translation="MKDMQPFTPVKSYTPFHSRFDPCPPIGKKYYRTPPNLYMTFQPE HMEQFSPMEALRKGTLWKDLYDFYENPYRGGDAHGKKG*" gene 755907..756155 /gene="cotJA" /locus_tag="BSU_06890" /old_locus_tag="BSU06890" CDS 756139..756402 /gene="cotJB" /locus_tag="BSU_06900" /old_locus_tag="BSU06900" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the inner spore coat" /protein_id="NP_388571.2" /db_xref="EnsemblGenomes-Gn:BSU06900" /db_xref="EnsemblGenomes-Tr:CAB12509" /db_xref="InterPro:IPR016571" /db_xref="InterPro:IPR024207" /db_xref="SubtiList:BG11800" /db_xref="UniProtKB/Swiss-Prot:Q45537" /translation="MAKKVDAEYYRQLEQIQAADFVLVELSLYLNTHPHDEDALKQFN QYSGYSRHLKRQFESSYGPLLQFGNSPAGKDWDWGKGPWPWQV*" gene 756139..756402 /gene="cotJB" /locus_tag="BSU_06900" /old_locus_tag="BSU06900" CDS 756417..756986 /gene="cotJC" /locus_tag="BSU_06910" /old_locus_tag="BSU06910" /EC_number="1.11.1.6" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7768848, 9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7768848, 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="enzyme component of the inner spore coat" /protein_id="NP_388572.1" /db_xref="EnsemblGenomes-Gn:BSU06910" /db_xref="EnsemblGenomes-Tr:CAB12510" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG11801" /db_xref="UniProtKB/Swiss-Prot:Q45538" /translation="MWVYEKKLQYPVKVSTCNPTLAKYLIEQYGGADGELAAALRYLN QRYTIPDKVIGLLTDIGTEEFAHLEMIATMVYKLTKDATPEQLREAGLGDHYVNHDSA LFYHNAAGVPFTASYIQAKGDPIADLYEDIAAEEKARATYQWLIDISDDPDLNDSLRF LREREIVHSMRFREAVEILKEERDKKKIF*" gene 756417..756986 /gene="cotJC" /locus_tag="BSU_06910" /old_locus_tag="BSU06910" S_feature 756987..757065 /Source="Nicolas_S_feature" /locus_tag="new_756987_757065" /HighExp="S4, S5, S3, S7, S6, B36, LoTm, BT, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S246" promotor_-35 757038..757043 /Source="Nicolas_upshift_promotors" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 757058..757077 /Source="Nicolas_upshift_promotors" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 757067 /Source="Nicolas_upshifts" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" CDS 757111..757653 /gene="yesJ" /locus_tag="BSU_06920" /old_locus_tag="BSU06920" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388573.1" /db_xref="EnsemblGenomes-Gn:BSU06920" /db_xref="EnsemblGenomes-Tr:CAB12511" /db_xref="GOA:O31513" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11809" /db_xref="UniProtKB/Swiss-Prot:O31513" /translation="MTAFKIENETIADGFYACPAVYEDAESITGLLVRTAEWLRDRGS NQWSGLLKGQDIHDITGSIEKGHVFVFKKDEELAAVVMLLPAPSEWDRTLWGDDGHEE SIYLHRLAVSRRFAGQGLGARVLQWAETGIHFPEKTRIRLDCVADSDALHSFYRRMGY EFMGADASGYHLFEKEITAE*" gene 757111..757653 /gene="yesJ" /locus_tag="BSU_06920" /old_locus_tag="BSU06920" downshifts 757620 /Source="Nicolas_upshifts" /id="D342" /incds=0 /nref=104 /ntot=251 /MaxReadThrough="3.04389" /MaxDrop="4.5316" /score="8.56782582" /energy="-5.8" /TU="U528" /idTUdmin="U530" /TUdmin=2 /isTUend="TRUE" CDS 757676..757978 /gene="yesK" /locus_tag="BSU_06930" /old_locus_tag="BSU06930" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_388574.2" /db_xref="EnsemblGenomes-Gn:BSU06930" /db_xref="EnsemblGenomes-Tr:CAB12512" /db_xref="GOA:O31514" /db_xref="InterPro:IPR025434" /db_xref="SubtiList:BG12845" /db_xref="UniProtKB/Swiss-Prot:O31514" /translation="MSFSKREAGDVWSILFVTGIVTACLFAGVSVLMRMRFPDKSRPE WMLAGLIVLGVFAIWYSLVYVRGWEGAALGMLGFNVIFGAIAGYLIDKAIRRYRKR*" gene 757676..757978 /gene="yesK" /locus_tag="BSU_06930" /old_locus_tag="BSU06930" promotor_-35 758021..758029 /Source="Nicolas_upshift_promotors" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 758040..758058 /Source="Nicolas_upshift_promotors" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 758046 /Source="Nicolas_upshifts" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" CDS 758093..758722 /gene="yesL" /locus_tag="BSU_06940" /old_locus_tag="BSU06940" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25441682; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease or sensor of a three componentsystem for pectin and rhamnogalacturonan transport anddegradation" /protein_id="NP_388575.1" /db_xref="EnsemblGenomes-Gn:BSU06940" /db_xref="EnsemblGenomes-Tr:CAB12513" /db_xref="GOA:O31515" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG12846" /db_xref="UniProtKB/Swiss-Prot:O31515" /translation="MLMIHSVANGLNHFCTWVMRLAYLNVLWILFSLAGLVVFGLMPA TAAMFTVAREWAKGNTDAPVFSVFFRTFKKEWRASQILGLIVVTAALFLFADMRIAAQ MDQPVLVNVFVSISLIFAFVVLYVFPVFSHFDVKIREVLSISFFIAFSRPAVTLLMAA GAVGVLCLVLFHVTFLLFFSGSLLSLILTKLSFKAFRSMDQRQEKEKAA*" gene 758093..758722 /gene="yesL" /locus_tag="BSU_06940" /old_locus_tag="BSU06940" CDS 758719..760452 /gene="yesM" /locus_tag="BSU_06950" /old_locus_tag="BSU06950" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 23436677, 25441682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 23436677, 25441682; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YesN]" /protein_id="NP_388576.1" /db_xref="EnsemblGenomes-Gn:BSU06950" /db_xref="EnsemblGenomes-Tr:CAB12514" /db_xref="GOA:O31516" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR033479" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12847" /db_xref="UniProtKB/Swiss-Prot:O31516" /translation="MKKRVAGWYRRMKIKDKLFVFLSLIMAVSFLFVYSGVQYAFHVY DEQIYRKSSEVLRMSSERIEDELKKIEDVSYEIITDEQIQRILSMQNRDDTYDQYQMK QELWDQLAGYASDEKYIDSIHVIDARGSEYSAGSSSSDLLQQEQEEVFKRAKAKSGRN LWMTLGGSDPVLISARQIRSYHQLSLNGLGMVLIQVNVKQMIRDVPKDWGDSVGDIMI ADQGGNLVYTAHASAHVPEAAKETLKHPGYDLIKKNGKRYFISYLQSSYQNWSYYNVI PFDQMFAKISFMKTVIGTCFLLFFCVVLLFGRKIANSITEPIEQLVTAMKSVQHSGIE AGVSLSLPEHTQDEAGMLNRHFTVMMKRINELMEENVEKQLIIKETELKALQAQINPH FLYNTLESINWLAKANQQKQISKMVESLGFLLRNSIHMKKDIVTIQEEADIVRHYMTI QRFRFEERLKFTLDIDDEVKHCLIPKLTLQPLAENAIQYALEPFTRPCAIRIQAKKAK GCVCITVEDNGPGMDGRILESTGGRGIGLWNIRERISLTFGEPYGLRIHSEHEKGTRI VITIPCRNEVV*" gene 758719..760452 /gene="yesM" /locus_tag="BSU_06950" /old_locus_tag="BSU06950" CDS 760452..761558 /gene="yesN" /locus_tag="BSU_06960" /old_locus_tag="BSU06960" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:25441682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25441682; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YesM]" /protein_id="NP_388577.1" /db_xref="EnsemblGenomes-Gn:BSU06960" /db_xref="EnsemblGenomes-Tr:CAB12515" /db_xref="GOA:O31517" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12848" /db_xref="UniProtKB/Swiss-Prot:O31517" /translation="MYKILLADDERIILDGMAGIIEWESLGASLIGKAQNGHEAYEKI VHKQPHIVITDVKMPGMDGLELIKKVSAVSPSVQFIVLSGFGEFEYAKEAMKYGVKHY LLKPCNEQQIISSLEEIIAELKRQDVHKKKTAHLKHELDHIRSFAADQYLEGLIAGVA QLSPPPSLAGKKIRLLILKGEQSIDAAAREALGSALTAVCSSGEWTVLAVEENAAEKV AEVFADRKMAISQAGELRHAGQLFRDTAEASGDLHGSAVISKMIRLIADELGNPNLSL KWAAKDMLFMNPDYLGKLFKQETGEKFSQYVTRVRLEHAMKQMKIRRDVSVSEIAEEI GFGDNPKYFSLVFKKYTGLTPSEFRRKQGGASAG*" gene 760452..761558 /gene="yesN" /locus_tag="BSU_06960" /old_locus_tag="BSU06960" downshifts 761512 /Source="Nicolas_upshifts" /id="D343" /incds=0 /nref=4 /ntot=43 /MaxReadThrough="0.271749999999999" /MaxDrop="3.41261" /score="3.12085441" /energy="-10.3" /TU="NA" /idTUdmin="U531" /TUdmin=1408 /isTUend="FALSE" promotor_-35 761597..761600 /Source="Nicolas_upshift_promotors" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 761615..761634 /Source="Nicolas_upshift_promotors" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 761622 /Source="Nicolas_upshifts" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 761662..762945 /gene="yesO" /locus_tag="BSU_06970" /old_locus_tag="BSU06970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 25658435" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 25658435; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="pectin degradation byproducts (rhamnose oligosaccharides)-binding lipoprotein" /protein_id="NP_388578.2" /db_xref="EnsemblGenomes-Gn:BSU06970" /db_xref="EnsemblGenomes-Tr:CAB12516" /db_xref="PDB:4R6K" /db_xref="SubtiList:BG12849" /db_xref="UniProtKB/Swiss-Prot:O31518" /translation="MKKICYVLLSLVCVFLFSGCSAGEEASGKKEDVTLRIAWWGGQP RHDYTTKVIELYEKKNPHVHIEAEFANWDDYWKKLAPMSAAGQLPDVIQMDTAYLAQY GKKNQLEDLTPYTKDGTIDVSSIDENMLSGGKIDNKLYGFTLGVNVLSVIANEDLLKK AGVSINQENWTWEDYEKLAYDLQEKAGVYGSNGMHPPDIFFPYYLRTKGERFYKEDGT GLAYQDDQLFVDYFERQLRLVKAKTSPTPDESAQIKGMEDDFIVKGKSAITWNYSNQY LGFARLTDSPLSLYLPPEQMQEKALTLKPSMLFSIPKSSEHKKEAAKFINFFVNNEEA NQLIKGERGVPVSDKVADAIKPKLNEEETNIVEYVETASKNISKADPPEPVGSAEVIK LLKDTSDQILYQKVSPEKAAKTFRKKANEILERNN*" gene 761662..762945 /gene="yesO" /locus_tag="BSU_06970" /old_locus_tag="BSU06970" CDS 762942..763871 /gene="rhgP" /locus_tag="BSU_06980" /old_locus_tag="BSU06980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691; Product type t: transporter" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan permease" /protein_id="NP_388579.1" /db_xref="EnsemblGenomes-Gn:BSU06980" /db_xref="EnsemblGenomes-Tr:CAB12517" /db_xref="GOA:O31519" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12850" /db_xref="UniProtKB/Swiss-Prot:O31519" /translation="MTGNGADAMKKSRSIRKDNLAGYAFISPFIIGFLCFTVIPMGAS LFLSFTSYDLFTAPKWIGLDNFKEMFTGDEKYWQSLKVTFTYVLAGVPLRLGFALFIA VILNNAAKGTAIYRTLFYLPSIIGGSVAVAIMWRNIFGNDGVINALLFFVGIDQKILW YQNPTSALWTLILLSVWQFGSSMLIFLAGLKNIPSSYLEAASVDGANRVQRFFKITLP ILTPIIFFNLVMQTISAFMTFTPAYIISKGEGGPLDGTLLYSLYLFQRAFNYFQMGYA SAMAWVMLVIVGLITLILFKTSSYWVHYESKEE*" gene 762942..763871 /gene="rhgP" /locus_tag="BSU_06980" /old_locus_tag="BSU06980" CDS 763875..764765 /gene="rhgQ" /locus_tag="BSU_06990" /old_locus_tag="BSU06990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691; Product type t: transporter" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan permease" /protein_id="NP_388580.1" /db_xref="EnsemblGenomes-Gn:BSU06990" /db_xref="EnsemblGenomes-Tr:CAB12518" /db_xref="GOA:O31520" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12851" /db_xref="UniProtKB/Swiss-Prot:O31520" /translation="MEPVNQPVREAPVFERKKAGRVSPKRILFHVFTATLAVLLLYPV IWLFVSSFKESASIFTTSHSLIPDPFILSNYAEGWKGIAGQPFLTFIKNSAIIVGLST IGAVMSSAVIAYGFARIPFKGKKFWFACMMGTLMLPHEVLMIPQYIMFAKLDWLNSFK PIVVPQFFGHAFFIFLMIQFIRTIPEELDEAARIDGCGRFACFWRIILPLIAPALATS AIFSFYWKWEELIQPLLYLNKPELYPVSLALKLFLDTESASNWGAMFAMSAVSLLPVI LVFFLFQKYIVQGISTTGLK*" gene 763875..764765 /gene="rhgQ" /locus_tag="BSU_06990" /old_locus_tag="BSU06990" CDS 764781..765815 /gene="rhgH" /locus_tag="BSU_07000" /old_locus_tag="BSU07000" /EC_number="3.2.1.172" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan hydrolase" /protein_id="NP_388581.1" /db_xref="EnsemblGenomes-Gn:BSU07000" /db_xref="EnsemblGenomes-Tr:CAB12519" /db_xref="GOA:O31521" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR010905" /db_xref="SubtiList:BG12852" /db_xref="UniProtKB/Swiss-Prot:O31521" /translation="MAQLIFDEEKVTSVIDRIVKRTFQMDFAWDWPGGVAFYGVAEAY EATENEEYINLLKTWVDEQLEDGLPPLSINGVSIGHTLLFLHKVTGDDVYLETAAEMA EYVLHKAPRFGEGILQHTVNAAEYVFPEQAWADTLMMAGLFMLRIGRVMEREDYFEDG LRQFHGHEDVLQDPVTNLYYHAWDNKAQNHLSGIYWGRANGWAALTMAKALPLIEVTH PSFMIIDGSLRDQLSALVRLQDESGLWHTILDDPDSYLEVSASAGIASALMSSGKLYT KYVQKSLAAILDAVEEDGRVSRVSAGTAVMKNAEGYKQVPYKRIQGWGQGLALTFLAD VLKTKKRLYQ*" gene 764781..765815 /gene="rhgH" /locus_tag="BSU_07000" /old_locus_tag="BSU07000" CDS 765838..768123 /gene="rhgR" /locus_tag="BSU_07010" /old_locus_tag="BSU07010" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19651770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19651770; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AraC/XylS family)" /protein_id="NP_388582.1" /db_xref="EnsemblGenomes-Gn:BSU07010" /db_xref="EnsemblGenomes-Tr:CAB12520" /db_xref="GOA:O31522" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG12853" /db_xref="UniProtKB/Swiss-Prot:O31522" /translation="MKKQPQQKERVSRWKGTYFKRNFVFILLIACIPGLLTGGAIYFL SIDKVEKELQRSHETQVAREVSRMDEKLGVLELALTQMAYDSSLMNGLAERDLEKDFT FSYQLTKKLFLLRDQQPLIEQASIFLNSPRPLVLSPEYSALTEQEALRKYRSLLASDH SIYWKRSGNQAMLIQLIPGAAEKPFGAIMLAVDPKEMESILQSLSPYPDGSALLLDQN REVLFHEGEKDFEKTLLHEIKKQPAENGHFQMEWKGKVYSVSFGEMNRMHQQWTFVSA APLSAITAPMVFLSKVIIVMLVICIGLAVCMTWYASKKIYRPIQHLLGLFTGGEKKTW QASGQDEFKWIEKRWQDLSLESRKLQQQLLRQTPHMKKSFLQHLLQSDFYYDNEESLR FRMEEAGWNIGGNVFHVLDLQVTGLRCEKSIFREGDEQLAVFTLTNIAEELAAKRVFQ LSILDIGRLSVTVLVMKTNSSDLKAYITELARQFGDVTGLCLTSTLSSKTERVTEIPS LFQDVKCGKSRRKFANRDQVIDLQADFPRDEQFAPYYPFELEKQIVQTIRLERKQEAK ELIDGCMKELSEKAAIDRHVHSALIQLFSRIQEDILHSGLNPSELFQHRNPFLDISEL REPNEAAAWLMDVVVTPYLSKLEGRKNRQQKQLAERVIAMIHEQYMADISLESCADAL GMNSYTLSKAFKQVTGINFIDYVTQIRIEKAKELLVNTNKKIHDVSEEVGYRHNYFNR IFKKQVGMPPGVFRQMYQETP*" gene 765838..768123 /gene="rhgR" /locus_tag="BSU_07010" /old_locus_tag="BSU07010" CDS 768137..768835 /gene="rhgT" /locus_tag="BSU_07020" /old_locus_tag="BSU07020" /EC_number="3.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 17957779" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 17957779; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan acetylesterase" /protein_id="NP_388583.1" /db_xref="EnsemblGenomes-Gn:BSU07020" /db_xref="EnsemblGenomes-Tr:CAB12521" /db_xref="GOA:O31523" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12854" /db_xref="UniProtKB/Swiss-Prot:O31523" /translation="MMKKPIQVFLAGDSTVSDCPPHEAPMAGWGQVFGQLFSEGVLVR NHAKGGASTNSFVEEGRLQAIAEHITQGDYLLIQFGHNDQKPRGTKPYSTFQQFLTLF ADTAREKGAHPVFVTSVQRRRFDENGRIEHTLGEYPDAMKALAKELDVPVIDLLAKTK VLYEAYGPEESKRLFVWFQPNEHPNYPDGIEDNTHFSEKGAMEVAKLVAEGIEELGLP LKDHLVSREGKEHV*" gene 768137..768835 /gene="rhgT" /locus_tag="BSU_07020" /old_locus_tag="BSU07020" CDS 768828..769490 /gene="yesU" /locus_tag="BSU_07030" /old_locus_tag="BSU07030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388584.1" /db_xref="EnsemblGenomes-Gn:BSU07030" /db_xref="EnsemblGenomes-Tr:CAB12522" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR015305" /db_xref="PDB:1OQ1" /db_xref="SubtiList:BG12855" /db_xref="UniProtKB/Swiss-Prot:O31524" /translation="MYKEGACLYRNPLRSKSDVKDWRMEGGGQISFDDHSLHLSHVQD EAHFVFWCPETFPDGIIVTWDFSPIEQPGLCMLFFAAAGIRGEDLFDPSLRKRTGTYP EYHSGDINALHLSYFRRKYAEERAFRTCNLRKSRGFHLAAMGADPLPSPDDADSPYRM KLIKDKGYVHFSINGLPILEWMDDGSTYGPVLTKGKIGFRQMAPMKAVYRDFAVHQAV RR*" gene 768828..769490 /gene="yesU" /locus_tag="BSU_07030" /old_locus_tag="BSU07030" CDS 769487..770113 /gene="yesV" /locus_tag="BSU_07040" /old_locus_tag="BSU07040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17449691; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane component" /protein_id="NP_388585.1" /db_xref="EnsemblGenomes-Gn:BSU07040" /db_xref="EnsemblGenomes-Tr:CAB12523" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG12856" /db_xref="UniProtKB/Swiss-Prot:O31525" /translation="MKTTVTDALYAGCEAVVKIAWLNGLWLLFTLLGGVLFGWAPSTA AMCAVIRKWLMGQKDVPIFSLFLDTYKKEFLKVNAIGLAFSALLLILSANYHYFSAST NWLSFAVTSCTLLAGLLYIIALMYVFPLYVHYQLPLRKYIPQALLFGAMRPLTTGCML IGCGFVLYLLYTLPGLIPFYGPCLFGLVLMFFALRGFQKTEAQHHQAG*" gene 769487..770113 /gene="yesV" /locus_tag="BSU_07040" /old_locus_tag="BSU07040" CDS 770234..772096 /gene="rhgW" /locus_tag="BSU_07050" /old_locus_tag="BSU07050" /EC_number="4.2.2.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19193638" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19193638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan endolyase" /protein_id="NP_388586.1" /db_xref="EnsemblGenomes-Gn:BSU07050" /db_xref="EnsemblGenomes-Tr:CAB12524" /db_xref="GOA:O31526" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR034641" /db_xref="PDB:2Z8R" /db_xref="PDB:2Z8S" /db_xref="PDB:2ZUX" /db_xref="SubtiList:BG12857" /db_xref="UniProtKB/Swiss-Prot:O31526" /translation="MRRSCLMIRRRKRMFTAVTLLVLLVMGTSVCPVKAEGAARQMEA LNRGLVAVKTDGGIFVSWRFLGTENASVLFNVYRDGQKLNAAPVKTTNYVDKNGSAGS TYTVRAVVNGTEQPASEKASVWAQPYHSVPLDKPAGGTTPKGESYTYSANDASVGDVD GDGQYELILKWDPSNSKDNSQDGYTGDVLIDAYKLDGTKLWRINLGKNIRAGAHYTQF MVYDLDGDGKAEVAMKTADGTKDGTGKVIGNANADYRNEQGRVLSGPEYLTVFQGSTG KELVTANFEPARGNVSDWGDSYGNRVDRFLAGIAYLDGQRPSLIMTRGYYAKTMLVAY NFRDGKLSKLWTLDSSKSGNEAFAGQGNHNLSIADVDGDGKDEIIFGSMAVDHDGKGM YSTGLGHGDALHTGDLDPGRPGLEVFQVHEDKNAKYGLSFRDAATGKILWGVYAGKDV GRGMAADIDPRYPGQEVWANGSLYSAKGVKIGSGVPSSTNFGIWWDGDLLREQLDSNR IDKWDYQNGVSKNMLTASGAAANNGTKATPTLQADLLGDWREEVVWRTEDSSALRIYT TTIPTEHRLYTLMHDPVYRLGIAWQNIAYNQPPHTSFFLGDGMAEQPKPNMYTP*" gene 770234..772096 /gene="rhgW" /locus_tag="BSU_07050" /old_locus_tag="BSU07050" promotor_no_box 770274..770374 /Source="Nicolas_upshift_promotors" /id="U533" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.000999000999001" /xcortree=1487 /SigmaFactorBS="tgtttaccgctgttacgttgctggtcttgttggtgatgggaa cctctgtatgtcctgtgaaagctgaaggggcagcgcggcagatggaagcgctgaaccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 770334 /Source="Nicolas_upshifts" /id="U533" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.000999000999001" /xcortree=1487 /SigmaFactorBS="tgtttaccgctgttacgttgctggtcttgttggtgatgggaa cctctgtatgtcctgtgaaagctgaaggggcagcgcggcagatggaagcgctgaaccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(770872) /Source="Nicolas_upshifts" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(770873..770892) /Source="Nicolas_upshift_promotors" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(770905..770914) /Source="Nicolas_upshift_promotors" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 772142..773980 /gene="rhgX" /locus_tag="BSU_07060" /old_locus_tag="BSU07060" /EC_number="4.2.2.24" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19193638" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19193638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan exolyase" /protein_id="NP_388587.1" /db_xref="EnsemblGenomes-Gn:BSU07060" /db_xref="EnsemblGenomes-Tr:CAB12525" /db_xref="GOA:O31527" /db_xref="InterPro:IPR013517" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR034641" /db_xref="PDB:2ZUY" /db_xref="SubtiList:BG12858" /db_xref="UniProtKB/Swiss-Prot:O31527" /translation="MKPKKRQMEYLTRGLIAVQTEQGVFVSWRFLGTDHETTAFHLYR DGKRITRDPIAESTNFLDQNGTADSVYQVAAVNKGREEKLSKKARVWQENVLEVPLAK PEGGVTPDGKPYTYSANDASVGDIDGDGEYEMILKWDPSNSKDNAHDGYTGEVLIDAY KLDGTFLWRINLGRNIRAGAHYTQFMVYDLDGDGKAEIAMKTADGTTDGKGHIIGDEQ ADFRNEQGRILSGPEYLTVFKGETGEALTTVEYEPPRGKLEDWGDGYGNRMDRFLAGT AYLDGERPSLVMARGYYTRTVLVAYDFRNGRLKKRWVFDSNQPGHEAYAGQGNHSLSV ADVDGDGKDEIIYGAMAVDHDGTGLYSTGLGHGDAMHVGDLDPSRKGLEVFQVHEDAT KPYGLSLRDAGTGEILWGVHAGTDVGRGMAAHIDPSYKGSLVWGIDPPGNDGMSYGLF TSKGEKISDKAPSSANFAIWWDGDLVRELLDHDWDGTIGRPKIEKWDAENGCLKTIFQ PAGVLSNNGTKGNPVLQANLFGDWREEVIWRTEDSSALRIYTTTHLTRHCFYTLMHDP VYRLGIAWQNTAYNQPPHTSFYLGTGMKKPPKPALYIAGSKAEAPL*" gene 772142..773980 /gene="rhgX" /locus_tag="BSU_07060" /old_locus_tag="BSU07060" CDS 774138..774791 /gene="yesY" /locus_tag="BSU_07070" /old_locus_tag="BSU07070" /EC_number="3.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan acetylesterase" /protein_id="NP_388588.1" /db_xref="EnsemblGenomes-Gn:BSU07070" /db_xref="EnsemblGenomes-Tr:CAB12526" /db_xref="GOA:O31528" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12859" /db_xref="UniProtKB/Swiss-Prot:O31528" /translation="MANHIYLAGDSTVQTYGDSTNQGGWGQFLGSHLPEHIQVINRAI GGRSSKTFVEEGRLQAILDVIEPDDWLFVQMGHNDASKNKPERYTEPYTTYKQYLKQY IAGAREKGAHPLLITPVARFHYENGVFLNDFPDYCIAMKQTAAEENVQLIDLMEKSLA FFTEKGEEKVYTYFMISEGINDYTHFTKKGANEMAKLVAKGIKELGLPLTESIIKER* " gene 774138..774791 /gene="yesY" /locus_tag="BSU_07070" /old_locus_tag="BSU07070" CDS 774799..776790 /gene="rhgZ" /locus_tag="BSU_07080" /old_locus_tag="BSU07080" /EC_number="3.2.1.67" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17056685, 17449691, 17485082" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17056685, 17449691, 17485082; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-galacturonidase" /protein_id="NP_388589.1" /db_xref="EnsemblGenomes-Gn:BSU07080" /db_xref="EnsemblGenomes-Tr:CAB12527" /db_xref="GOA:O31529" /db_xref="InterPro:IPR003476" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013738" /db_xref="InterPro:IPR013739" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12860" /db_xref="UniProtKB/Swiss-Prot:O31529" /translation="MRKLYHGACYYPELWDEETIQQDIDIMREVGVNVVRIGEFAWSV MEPEEGKIDVGFFKEIIARLYDSGIETIMCTPTPTPPIWFSHGRPERMHANEKREIMG HGSRQHACTNNPYFRKKAAIITTAIAKELGRLPGLIGWQLDNEFKCHVAECMCETCLR LWHDWLKNRYGVIERLNEAWGTDVWSETYQTFEQVPQPGPAPFLHHASLRTMYQLFSM EMIASFADEQAKIIRCYSDAPITHNGSVMFSVDNERMFQNLDFASYDTYASQENASAF LLNCDLWRNLKQGRPFWILETSPSYAASLESSAYPHADGYLQAEAVSSYALGSQGFCY WLWRQQRSGSEISHGSVLSAWGEPTIGYQNVLAVERARKEIEPIILSTEPVQAEAAMT YSDRAKAFIKTEPHRGLRHRSLVTHFYERILNTGIHRDLIPEGAPLDGYRLLFTPFVP YLSSEFIKKASAFAEAGGIWITGPLTGGRTCEHTIHTDCGLGELEKTSGIKTLFTFPM NENVNTGKAFGITAPLGLWSAVFDTESGNTLGTVEAGPGAGHAFLTERNYGEGKIVML GSLPSGKEGDAMLEALVRHYAEEAVISSRSDVTPGTIVAPRIGENGLVWIVVNMDGKG GSVTLPESGTDLLTHRLEKAGRLAVGPHEYRVIQFDNHS*" gene 774799..776790 /gene="rhgZ" /locus_tag="BSU_07080" /old_locus_tag="BSU07080" CDS 776834..779407 /gene="yetA" /locus_tag="BSU_07090" /old_locus_tag="BSU07090" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388590.2" /db_xref="EnsemblGenomes-Gn:BSU07090" /db_xref="EnsemblGenomes-Tr:CAB12528" /db_xref="SubtiList:BG12861" /db_xref="UniProtKB/Swiss-Prot:O31530" /translation="MKKIKWLSGQPKVTSGVTWGMPWKKGELKKGDRLALMNENAETR YVQSEPSAYWPDGSIKWTKHAAVFGGQENQSFTVHKREVPQPTESLSILETEHDIQVD TGALVCTIHKTGSDFIQSLQINGKPIAAGGRLVAIRETRKESAAKMVLLHERSVSFIK RAAIEQSGPVKAVVKIEGVHVLHKTYEEWLPFVIRLTFYAGLSEIGLVHTQLIDRSGK LEFVKGLGIEFDLFLEGEPYNRHFRFAGEKGMYKEPAQLFGTRKFNERYPLYEKQING EMLSPDEEHKEWFAHGTQNAVWDDVKIVQDSSDHYSLSKRTGKDYAWVGMLHGSRAKG LCYAGGKNGGVALGLRYFFEKYPSALEITGLAGSRPKMTIWLWPPDGEAMDLRHYTGN THVASAYEGFDEMRSDPTGIANTNEISLACFSHMPSDEVLNALADKWQAPPLIVCEPD VYYESKALGVWSIIDTSHPLKKELEEQLDAAFLFYKKEVEQRRWYGFWHYGDVMHTYD PIRHMWRYDLGGYAWQNNELVPTLWLWQAFFRSGREDIFRMAEAMTRHTSETDSFHLG EYAGLGSRHNVVHWGCGCKEARISMAGLHKFYYYLTGDDRTGDLLTEVKDADYALVKT DPMRAFYEKGKHPTHARTGPDWAAFCSNWLAEWERTENSEYLKKIETGINCLKRLPLR LLSGPTFEYDPATSMLHHMGDGIAGGYHMIIAFGAPQVWMELAELLDDWEWEDMLSEF GEFYTLSDEEKRKKSGGALHDGHFHWPMFAAGMTAYAARKKQDPHLAAKAWNLLLEDK LSHTPLPIKPERIETWTQLEELPWVTTNTVSQWCLNVIAALELIGDSLPAKKETSGKK G*" gene 776834..779407 /gene="yetA" /locus_tag="BSU_07090" /old_locus_tag="BSU07090" promotor_-10 complement(778156..778174) /Source="Nicolas_upshift_promotors" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(778169) /Source="Nicolas_upshifts" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(778190..778195) /Source="Nicolas_upshift_promotors" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 779529..781037 /gene="lplA" /locus_tag="BSU_07100" /old_locus_tag="BSU07100" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921237; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein transporter binding protein for alpha-galacturonides" /protein_id="NP_388591.1" /db_xref="EnsemblGenomes-Gn:BSU07100" /db_xref="EnsemblGenomes-Tr:CAB12529" /db_xref="GOA:P37966" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG10434" /db_xref="UniProtKB/Swiss-Prot:P37966" /translation="MKIRMRKKWMALPLAAMMIAGCSHSETSNSASGSKDTIKIMAPL LSPESPSDKSPSLKALEKYTGKEIKVTWVPDSSYNDKFNIVMASGEMPHAIVIKDKSA GFIKSVKAGAFWELSPYLKDYKNLSQADEKILKNSSVNGEVYGIYRTRDLIRACMIIR TDWLKNVGLDMPETLDDFYEVLKAFKEKDPDGNGKDDTYGMVVPKWMGLGNGSPWDVL QIWFGAPNRYGVENGKLIPDFTTKEYMDALTFFKKLYDEGLINKDFAVMDSAKWNDPV VKGKAGVIVDTGSRASQIQSAMEEADESNKDIIDIVGSLEGPNGKRTFPTSGYSGMIT IPKSSVKTEKELKEVLSFLDKMNDKEAQILTNNGVKGRNYELKDGVFTSLEKNNKSLL YEHEGLAQFSMSIPKSEYYIEDQKTKLFQHRKDIITEGEKIAVFNPAESLVSDVYTQK GAQLDNIILDARTQFIIGEIDEKGFDDAVELWKKSGGNELMKDLNKLYQSSK*" gene 779529..781037 /gene="lplA" /locus_tag="BSU_07100" /old_locus_tag="BSU07100" CDS 781092..782048 /gene="lplB" /locus_tag="BSU_07110" /old_locus_tag="BSU07110" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10869078, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) for alpha-galacturonides" /protein_id="NP_388592.1" /db_xref="EnsemblGenomes-Gn:BSU07110" /db_xref="EnsemblGenomes-Tr:CAB12530" /db_xref="GOA:P39128" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10435" /db_xref="UniProtKB/Swiss-Prot:P39128" /translation="METVPKKRDAPVLTAGKGISWMAALKRDKWLYLLLIPGLLYFLI FKYLPMWGVLIAFKDYSPYLGFWKSEWVGFDYFKDFFMNPDFFRLLRNTLMLASLDLL FAFPAPLILALLLNEVRKAVYKRCIQTFIYVPHFVSWTIVVSITFVFFTVDTGVINKL IMSLTGEQISFLSDADWFRPMIVMQSIWKETGWGTILFLAALATVDQEQYEAAIMDGA GRFRRMWHITLPAIRSTIIVLLILRIGSFLNLGFEQVYLMTNSLNRSVADIFDTYVYM MGITQGAYSYSTAVGLFKSVVGIILIFGANYIAKKFDQEGLF*" gene 781092..782048 /gene="lplB" /locus_tag="BSU_07110" /old_locus_tag="BSU07110" downshifts complement(781366) /Source="Nicolas_upshifts" /id="D344" /incds=1 /nref=1 /ntot=8 /MaxReadThrough="1.59638" /MaxDrop="4.19822" /score="13.9744253" /energy="-20.3" /TU="NA" /idTUdmin="U538" /TUdmin=2068 /isTUend="FALSE" promotor_no_box complement(781392..781492) /Source="Nicolas_upshift_promotors" /id="U536" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.002997002997003" /xcortree=1476 /SigmaFactorBS="ggtacgtaaataaaggtttggatacatcttttatacacggcc tttcttacctcattcaaaagcagagccaaaatgagaggcgcgggaaaggcaaacaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(781432) /Source="Nicolas_upshifts" /id="U536" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.002997002997003" /xcortree=1476 /SigmaFactorBS="ggtacgtaaataaaggtttggatacatcttttatacacggcc tttcttacctcattcaaaagcagagccaaaatgagaggcgcgggaaaggcaaacaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 782062..782949 /gene="lplC" /locus_tag="BSU_07120" /old_locus_tag="BSU07120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10869078, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) for alpha-galacturonides" /protein_id="NP_388593.1" /db_xref="EnsemblGenomes-Gn:BSU07120" /db_xref="EnsemblGenomes-Tr:CAB12531" /db_xref="GOA:P39129" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10857" /db_xref="UniProtKB/Swiss-Prot:P39129" /translation="MAEIHTMHNTKAGRVFDVCNILFLGGVGAITILPFLYIIAGSFA TEAELAQRSFFIFPKTFTLDAYKYVFSTPTFLRSMGVSIFITVVGTAVQLFFTFTMAY PLAKRHVKGRNLLLNLVIFSMLFSGGMIPTYLVVKSLGLLDTYWALILPMAINPFNLI IIKNFFQQLPRELEESAKIDGCSEIGVFWRIALPLSKPVIATFALFYAVGIWNDFFHA LLYINDSAKWPLQMVLRQVTILSDLTATNGDTMQNAVPPEQGIKLAVIVIATLPILAV YPFLQKHFAKGMLIGSVKG*" gene 782062..782949 /gene="lplC" /locus_tag="BSU_07120" /old_locus_tag="BSU07120" promotor_-35 782696..782701 /Source="Nicolas_upshift_promotors" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 782717..782735 /Source="Nicolas_upshift_promotors" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 782720 /Source="Nicolas_upshifts" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" CDS 782958..784298 /gene="lplD" /locus_tag="BSU_07130" /old_locus_tag="BSU07130" /EC_number="3.2.1.67" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:23416295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23416295; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-galacturonidase" /protein_id="NP_388594.1" /db_xref="EnsemblGenomes-Gn:BSU07130" /db_xref="EnsemblGenomes-Tr:CAB12532" /db_xref="GOA:P39130" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="PDB:3FEF" /db_xref="SubtiList:BG10858" /db_xref="UniProtKB/Swiss-Prot:P39130" /translation="MFHISTLDQIKIAYIGGGSQGWARSLMSDLSIDERMSGTVALYD LDFEAAQKNEVIGNHSGNGRWRYEAVSTLKKALSAADIVIISILPGSLDDMEVDVHLP ERCGIYQSVGDTVGPGGIIRGLRAVPIFAEIARAIRDYAPESWVINYTNPMSVCTRVL YKVFPGIKAIGCCHEVFGTQKLLAEMVTERLGIEVPRREDIRVNVLGINHFTWITKAS YRHIDLLPIFREFSAHYGESGYELEGECWRDSVFCSAHRVAFDLFETYGAIPAAGDRH LAEFLPGPYLKQPEVWKFHLTPISFRKQDRAEKRQETERLIVQQRGVAEKASGEEGVN IIAALLGLGELVTNVNMPNQGQVLNLPIQAIVETNAFITRNRVQPILSGALPKGVEML AARHISNQEAVADAGLTKDTGLAFQAFLNDPLVQIDRSDAEQLFNDMLQCIMQS*" gene 782958..784298 /gene="lplD" /locus_tag="BSU_07130" /old_locus_tag="BSU07130" S_feature complement(783392..785083) /Source="Nicolas_S_feature" /locus_tag="new_783392_785083_c" /HighExp="H2O2, dia15, Paraq, Lbexp, LBGexp, Salt, LPhT, GM 25, G150, dia0" /AntisenseName="yetF" /AntisenseCor="-0.25986434675098202" /AntisenseRegPval="-4.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S247" S_feature 784299..784380 /Source="Nicolas_S_feature" /locus_tag="new_784299_784380" /HighExp="S5, S4, S6, S3, S7, S8, BT, LoTm, B36, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S248" CDS 784381..785076 /gene="yetF" /locus_tag="BSU_07140" /old_locus_tag="BSU07140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388595.1" /db_xref="EnsemblGenomes-Gn:BSU07140" /db_xref="EnsemblGenomes-Tr:CAB12533" /db_xref="GOA:O31533" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="PDB:3C6F" /db_xref="SubtiList:BG12862" /db_xref="UniProtKB/Swiss-Prot:O31533" /translation="MGNYLSVAVELVCGLGILFIILKLLGKTQFSQITPFDFISALIL GELVGNAVYDHEIKIKEIIFASLLWGVLIYIIEFITQKMKSSRKFLEGEPNIVIRKGE LQYKVMKKNKIDINQLQSLLRQAGSFSIQEVEYAILETNGMVSVLPKSDFDKPTNKDL QIPSKSVSLPITLIIDGEIVRDNLKEAGVDEQWLKQELKKKNIDKTEDVLFAEWHKNK PLYTVTYEQSRST*" gene 784381..785076 /gene="yetF" /locus_tag="BSU_07140" /old_locus_tag="BSU07140" downshifts 785074 /Source="Nicolas_upshifts" /id="D345" /incds=0 /nref=2 /ntot=24 /MaxReadThrough="1.32891" /MaxDrop="3.45213" /score="-0.176154378" /energy="-7.1" /TU="NA" /idTUdmin="U537" /TUdmin=0 /isTUend="TRUE" CDS complement(785113..785439) /gene="hmoA" /locus_tag="BSU_07150" /old_locus_tag="BSU07150" /EC_number="1.14.14.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:20180905, 21764939, 21873409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20180905, 21764939, 21873409; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heme-degrading monooxygenase" /protein_id="NP_388596.2" /db_xref="EnsemblGenomes-Gn:BSU07150" /db_xref="EnsemblGenomes-Tr:CAB12534" /db_xref="GOA:O31534" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12863" /db_xref="UniProtKB/Swiss-Prot:O31534" /translation="MFVQLRKMTVKEGFADKVIERFSAEGIIEKQEGLIDVTVLEKNV RRGDEEVVVMIRWESEDHWKQWEKSDAHIAGHKANKGKPKPDYLISTEVSMYHVRAVK QGTYNQ*" gene complement(785113..785439) /gene="hmoA" /locus_tag="BSU_07150" /old_locus_tag="BSU07150" downshifts complement(785128) /Source="Nicolas_upshifts" /id="D346" /incds=0 /nref=194 /ntot=248 /MaxReadThrough="4.01189" /MaxDrop="6.29183" /score="9.23596913" /energy="-9.1" /TU="U538" /idTUdmin="U539" /TUdmin=0 /isTUend="TRUE" downshifts 785426 /Source="Nicolas_upshifts" /id="D347" /incds=1 /nref=1 /ntot=45 /MaxReadThrough="1.96802" /MaxDrop="3.46057" /score="-7.34187128" /energy="-5" /TU="NA" /idTUdmin="U537" /TUdmin=352 /isTUend="FALSE" promotor_-10 complement(785462..785481) /Source="Nicolas_upshift_promotors" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(785480) /Source="Nicolas_upshifts" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" promotor_-35 complement(785496..785503) /Source="Nicolas_upshift_promotors" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(785543..785905) /gene="yetH" /locus_tag="BSU_07160" /old_locus_tag="BSU07160" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase/dioxygenase" /protein_id="NP_388597.1" /db_xref="EnsemblGenomes-Gn:BSU07160" /db_xref="EnsemblGenomes-Tr:CAB12535" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12864" /db_xref="UniProtKB/Swiss-Prot:O31535" /translation="MIKQIGTVAVYVEDQQKAKQFWTEKVGFDIAADHPMGPEASWLE VAPKGAETRLVIYPKAMMKGSEQMKASIVFECEDIFGTYEKMKTNGVEFLGEPNQMEW GTFVQFKDEDGNVFLLKE*" gene complement(785543..785905) /gene="yetH" /locus_tag="BSU_07160" /old_locus_tag="BSU07160" promotor_-10 complement(785928..785947) /Source="Nicolas_upshift_promotors" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="promotor_-10" upshifts complement(785942) /Source="Nicolas_upshifts" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" promotor_-35 complement(785960..785966) /Source="Nicolas_upshift_promotors" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="promotor_-35" S_feature complement(785976..786536) /Source="Nicolas_S_feature" /locus_tag="new_785976_786536_c" /HighExp="S8, S6, S7, S5, BT, B36, G/S, B60, Pyr, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99999400000000005" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S249" downshifts complement(786008) /Source="Nicolas_upshifts" /id="D348" /incds=0 /nref=38 /ntot=47 /MaxReadThrough="0.395850000000001" /MaxDrop="8.2984" /score="45.4672528" /energy="-13.7" /TU="NA" /idTUdmin="U540" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(786519..786538) /Source="Nicolas_upshift_promotors" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(786536) /Source="Nicolas_upshifts" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" promotor_-35 complement(786552..786561) /Source="Nicolas_upshift_promotors" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 786624..786631 /Source="Nicolas_upshift_promotors" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 786640 /Source="Nicolas_upshifts" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" promotor_-10 786644..786663 /Source="Nicolas_upshift_promotors" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 786689..787270 /gene="yetI" /locus_tag="BSU_07170" /old_locus_tag="BSU07170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11157946; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="putative paralog of RsbR; N-terminal part of YetI" /db_xref="SubtiList:BG12865" /translation="MNIDQLLYQYIIDNTADITEKWFSLRCQLKGELYSASHLSEETK TLLTEQHTFTNITIASAFLEDQTDFQENMTKWAQNVAKNRVEQDVQVHEVVEAISNSR ISFWDAVATFIKENQEIVTNEDADRWNRIVNQSFDKLIIEFSEQYQKFMLMRLTSQQE LISELGCPVISIADGIGILPLIGSIDTKRHRSF*" gene 786689..787270 /gene="yetI" /locus_tag="BSU_07170" /old_locus_tag="BSU07170" /pseudo CDS 787264..787560 /gene="yetI" /locus_tag="BSU_07180" /old_locus_tag="BSU07180" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11157946; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="putative paralog of RsbR; C-terminal part of YetI" /db_xref="GOA:O31537" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="PSEUDO:CAB12537.2" /db_xref="SubtiList:BG12873" /db_xref="UniProtKB/Swiss-Prot:O31537" /translation="MLETVPVRCVERKITSLVVDLSGVPIVDTMVAQQLYNLSKTLFL LGVKAVFSGIRPDVAQTSIQLGLDFSEYETYGTLKQALENMGVRCIVEELEENK*" gene 787264..787560 /gene="yetI" /locus_tag="BSU_07180" /old_locus_tag="BSU07180" /pseudo downshifts 787552 /Source="Nicolas_upshifts" /id="D349" /incds=0 /nref=114 /ntot=215 /MaxReadThrough="1.06939" /MaxDrop="4.8053" /score="16.356572" /energy="-21.2" /TU="NA" /idTUdmin="U541" /TUdmin="-8" /isTUend="TRUE" promotor_-35 787631..787638 /Source="Nicolas_upshift_promotors" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 787652..787671 /Source="Nicolas_upshift_promotors" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 787660 /Source="Nicolas_upshifts" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" CDS 787715..787882 /gene="yezD" /locus_tag="BSU_07190" /old_locus_tag="BSU07190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388600.1" /db_xref="EnsemblGenomes-Gn:BSU07190" /db_xref="EnsemblGenomes-Tr:CAB12538" /db_xref="InterPro:IPR018743" /db_xref="SubtiList:BG12875" /db_xref="UniProtKB/Swiss-Prot:O31538" /translation="MVSKSTIDPEVIEKIISSLETLDFGTVQITVHDSQITQIEKIEK HRFSLKRKESK*" gene 787715..787882 /gene="yezD" /locus_tag="BSU_07190" /old_locus_tag="BSU07190" promotor_-35 787924..787931 /Source="Nicolas_upshift_promotors" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 787947..787966 /Source="Nicolas_upshift_promotors" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 787948 /Source="Nicolas_upshifts" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" CDS 787992..788636 /gene="calJ" /locus_tag="BSU_07200" /old_locus_tag="BSU07200" /function="7.4: Cations and iron carrying compounds" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 16086852, 24904158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 16086852, 24904158; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pH-sensitive calcium-leak permease (di-aspartyl pH sensor)" /protein_id="NP_388601.1" /db_xref="EnsemblGenomes-Gn:BSU07200" /db_xref="EnsemblGenomes-Tr:CAB12539" /db_xref="GOA:O31539" /db_xref="InterPro:IPR006214" /db_xref="PDB:4PGR" /db_xref="PDB:4PGS" /db_xref="PDB:4PGU" /db_xref="PDB:4PGV" /db_xref="PDB:4PGW" /db_xref="PDB:4TKQ" /db_xref="SubtiList:BG12866" /db_xref="UniProtKB/Swiss-Prot:O31539" /translation="MQATVHESKQSIMQRILTVFVFTLLIATVGLFIGQFVPVALMLP LSILEVAMIILAFWMRRRKAVGYAFVYTFAFVSGITLFPIVSHYASIAGAYVVLEAFG STFVIFAVLGTIGAKMKKDLSFLWSFLLVAVLALAVVGIFNIFSPLNSAAMMAYSVIG TIVFSLYILYDLNQIKHRHITEDLIPVMALSLYLDFINLFINLLRFFGILSSDD*" gene 787992..788636 /gene="calJ" /locus_tag="BSU_07200" /old_locus_tag="BSU07200" downshifts 788572 /Source="Nicolas_upshifts" /id="D350" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="6.69003" /MaxDrop="2.5446" /score="-1.46791202" /energy="-10.7" /TU="U542,U543" /idTUdmin="U541" /TUdmin=1012 /isTUend="FALSE" downshifts 788616 /Source="Nicolas_upshifts" /id="D351" /incds=0 /nref=7 /ntot=127 /MaxReadThrough="5.33515" /MaxDrop="3.71552" /score="-1.46791202" /energy="-10.7" /TU="U542,U543" /idTUdmin="U542" /TUdmin="-990" /isTUend="FALSE" CDS 788636..789628 /gene="yetK" /locus_tag="BSU_07210" /old_locus_tag="BSU07210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388602.1" /db_xref="EnsemblGenomes-Gn:BSU07210" /db_xref="EnsemblGenomes-Tr:CAB12540" /db_xref="GOA:O31540" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12867" /db_xref="UniProtKB/Swiss-Prot:O31540" /translation="MKKRLSLDRRFLPYIKKAGGVLVKKQMGAYVSLAAAMAIVGSSV VVGKLMVERIPVFLSSGLRFLIASVVLLMLLFCIEKGFPALTKKDVFVLLVQSFTGVF LFSICLLYGVQYTTGTESGILTSTTPMLIGILSFFLLREKIEKKTLIGILLAVCGVMA INLFGAGSQDGTPHALFGNMLIIAAVIGEALFTLMAKLLSPHISALAISTFVSLFGFL FFLPFALFEASSFDYSVPTVLDWSYVLYYALFVTVLAFYLWYSGVTKVPAGVSGIFTS VLPVSAVILSGVILKEPFEFVHFIGIACVIGGIFVTVIKKKQPDAYPAAEEKTL*" gene 788636..789628 /gene="yetK" /locus_tag="BSU_07210" /old_locus_tag="BSU07210" downshifts 789562 /Source="Nicolas_upshifts" /id="D352" /incds=1 /nref=1 /ntot=18 /MaxReadThrough="4.14475" /MaxDrop="2.73453" /score="21.8095329" /energy="-10.7" /TU="U542,U543" /idTUdmin="U542" /TUdmin="-44" /isTUend="FALSE" downshifts 789606 /Source="Nicolas_upshifts" /id="D353" /incds=0 /nref=94 /ntot=214 /MaxReadThrough="0.120229999999999" /MaxDrop="4.45909" /score="21.8095329" /energy="-10.7" /TU="NA" /idTUdmin="U542" /TUdmin=0 /isTUend="TRUE" CDS complement(789652..790155) /gene="flvL" /locus_tag="BSU_07220" /old_locus_tag="BSU07220" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19329649, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19329649, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (FlvL-flavonoids)" /protein_id="NP_388603.1" /db_xref="EnsemblGenomes-Gn:BSU07220" /db_xref="EnsemblGenomes-Tr:CAB12541" /db_xref="GOA:O31541" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12868" /db_xref="UniProtKB/Swiss-Prot:O31541" /translation="MELKHLPKYKHITEHAETYANIDAGSLELFLSLFDISKKMNHVM EHYFAGRGLSEGKFKILMLLFDAKDHRLSPTELAKRSNVTKATITGLLDGLARDGFVS RRHHTEDKRKISIELTTEGKARLEQFLPGHFSKISAVMENYSDEEKDMFVKMLGDLFE RLSVFKD*" gene complement(789652..790155) /gene="flvL" /locus_tag="BSU_07220" /old_locus_tag="BSU07220" promotor_-10 complement(790180..790199) /Source="Nicolas_upshift_promotors" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(790188) /Source="Nicolas_upshifts" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" promotor_-35 complement(790213..790220) /Source="Nicolas_upshift_promotors" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 790318..791427 /gene="flvM" /locus_tag="BSU_07230" /old_locus_tag="BSU07230" /EC_number="1.14.13.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25209494; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavin-dependent hydroxylase/monooxygenase acting on salicylate derivatives" /protein_id="NP_388604.1" /db_xref="EnsemblGenomes-Gn:BSU07230" /db_xref="EnsemblGenomes-Tr:CAB12542" /db_xref="GOA:O06489" /db_xref="InterPro:IPR002938" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12869" /db_xref="UniProtKB/Swiss-Prot:O06489" /translation="MKHMLIAGGGIGGLSAAISLRKAGFSVTLCEAASENRKTGAGIL QPQNALAVLKELGVFEDCCKHGFQTEWFKTFDEQGNLLFQVSESFLDDSLPGRNNILR KTLNDILMKHAEAVGVDIKWGKKVVAYEETAESVTALCEDGEKMQADILAGFDGIHSV VRDKMLQKETEKEHLGMGAWRFYIELPDYTFEDATFMYRSGDTQIGVVPLAQHAGYVF VLQPCTSDYWDEEDTRFDRVKEILSGFRGLDFVTKHMSKQHPVIFNKLEQVAVQEPWH KGRVIIGGDAAHAGAPTLAQGAAMAIEDAIVLAEELQNHADHETALQAYYKRRAPRAL KVQNLSSEIVRRRLKGEPGAEELIGECYAVLREGY*" gene 790318..791427 /gene="flvM" /locus_tag="BSU_07230" /old_locus_tag="BSU07230" downshifts 791410 /Source="Nicolas_upshifts" /id="D354" /incds=0 /nref=7 /ntot=67 /MaxReadThrough="0.0953400000000002" /MaxDrop="5.1482" /score="13.261567" /energy="-12.6" /TU="NA" /idTUdmin="U542" /TUdmin=1804 /isTUend="FALSE" CDS complement(791462..792532) /gene="yetN" /locus_tag="BSU_07240" /old_locus_tag="BSU07240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388605.1" /db_xref="EnsemblGenomes-Gn:BSU07240" /db_xref="EnsemblGenomes-Tr:CAB12543" /db_xref="InterPro:IPR025006" /db_xref="InterPro:IPR025012" /db_xref="SubtiList:BG12870" /db_xref="UniProtKB/Swiss-Prot:O06490" /translation="MDFEIRFLSFYVIQVEGKDEQANKQFKHFQTLDTGEFEESELKD FLDGELKKIVKRKADRHPQSEQVPTKIGHFIVEPGHELDSNPNYNMFNRARLAETKED FNELSEQFVRTYLDTSAVRGGVFLVASAVPRKYFDESFVFIMKCDFEPKVARISDASS LIKKVEMAITTKNMKSIQYPYMPEEGMVEEGELKIHQASHARYFEDFLKFVEYGESMP EIMKNQVMNMVQEHVYETFEDNSEELKQFEHDIEIWEASEKREIQERLDTHQVIEASA QIIEHTPEAQLKMKVGETEIKGLLADFGDSIHLAKVNGRYVALIEAETISFEKGSSPV EFYKPEGLHEVIERIRNKTEQD*" gene complement(791462..792532) /gene="yetN" /locus_tag="BSU_07240" /old_locus_tag="BSU07240" downshifts complement(791486) /Source="Nicolas_upshifts" /id="D355" /incds=0 /nref=45 /ntot=180 /MaxReadThrough="0.83729" /MaxDrop="4.28938" /score="0.323038441" /energy="-11.6" /TU="NA" /idTUdmin="U545" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(792563..792582) /Source="Nicolas_upshift_promotors" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(792589) /Source="Nicolas_upshifts" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" promotor_-35 complement(792597..792604) /Source="Nicolas_upshift_promotors" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 792612..792618 /Source="Nicolas_upshift_promotors" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 792633..792651 /Source="Nicolas_upshift_promotors" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 792642 /Source="Nicolas_upshifts" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" CDS 792682..795867 /gene="cypD" /locus_tag="BSU_07250" /old_locus_tag="BSU07250" /EC_number="1.6.2.4" /EC_number="1.14.14.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11574077, 2544578, 21048857, 26452461; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional P-450/NADPH-P450 reductase 1" /protein_id="NP_388606.1" /db_xref="EnsemblGenomes-Gn:BSU07250" /db_xref="EnsemblGenomes-Tr:CAB12544" /db_xref="GOA:O08394" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12871" /db_xref="UniProtKB/Swiss-Prot:O08394" /translation="MKETSPIPQPKTFGPLGNLPLIDKDKPTLSLIKLAEEQGPIFQI HTPAGTTIVVSGHELVKEVCDEERFDKSIEGALEKVRAFSGDGLFTSWTHEPNWRKAH NILMPTFSQRAMKDYHEKMVDIAVQLIQKWARLNPNEAVDVPGDMTRLTLDTIGLCGF NYRFNSYYRETPHPFINSMVRALDEAMHQMQRLDVQDKLMVRTKRQFRYDIQTMFSLV DSIIAERRANGDQDEKDLLARMLNVEDPETGEKLDDENIRFQIITFLIAGHETTSGLL SFATYFLLKHPDKLKKAYEEVDRVLTDAAPTYKQVLELTYIRMILNESLRLWPTAPAF SLYPKEDTVIGGKFPITTNDRISVLIPQLHRDRDAWGKDAEEFRPERFEHQDQVPHHA YKPFGNGQRACIGMQFALHEATLVLGMILKYFTLIDHENYELDIKQTLTLKPGDFHIS VQSRHQEAIHADVQAAEKAAPDEQKEKTEAKGASVIGLNNRPLLVLYGSDTGTAEGVA RELADTASLHGVRTKTAPLNDRIGKLPKEGAVVIVTSSYNGKPPSNAGQFVQWLQEIK PGELEGVHYAVFGCGDHNWASTYQYVPRFIDEQLAEKGATRFSARGEGDVSGDFEGQL DEWKKSMWADAIKAFGLELNENADKERSTLSLQFVRGLGESPLARSYEASHASIAENR ELQSADSDRSTRHIEIALPPDVEYQEGDHLGVLPKNSQTNVSRILHRFGLKGTDQVTL SASGRSAGHLPLGRPVSLHDLLSYSVEVQEAATRAQIRELASFTVCPPHRRELEELSA EGVYQEQILKKRISMLDLLEKYEACDMPFERFLELLRPLKPRYYSISSSPRVNPRQAS ITVGVVRGPAWSGRGEYRGVASNDLAERQAGDDVVMFIRTPESRFQLPKDPETPIIMV GPGTGVAPFRGFLQARDVLKREGKTLGEAHLYFGCRNDRDFIYRDELERFEKDGIVTV HTAFSRKEGMPKTYVQHLMADQADTLISILDRGGRLYVCGDGSKMAPDVEAALQKAYQ AVHGTGEQEAQNWLRHLQDTGMYAKDVWAGI*" gene 792682..795867 /gene="cypD" /locus_tag="BSU_07250" /old_locus_tag="BSU07250" downshifts 795854 /Source="Nicolas_upshifts" /id="D356" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.31156" /MaxDrop="2.91666" /score="9.17315362" /energy="-9.8" /TU="NA" /idTUdmin="U546" /TUdmin=44 /isTUend="FALSE" promotor_-35 795917..795922 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 795938..795956 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 795959 /Source="Nicolas_upshifts" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" promotor_-35 795987..795990 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 796007..796026 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 796008..796313 /Source="Nicolas_S_feature" /locus_tag="new_796008_796313" /HighExp="H2O2, Paraq, Oxctl, Cold, Heat, LBGexp, G180, G150, HPh, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.841" /TUlongSig="NA" /TUlongPSig="NA" /label="S250" upshifts 796008 /Source="Nicolas_upshifts" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" CDS 796314..798233 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11544192, 15187182, 17434969, 17483484, 21255105, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="exported glycerol phosphate lipoteichoic acid synthetase and anion-binding protein" /protein_id="NP_388607.2" /db_xref="EnsemblGenomes-Gn:BSU07260" /db_xref="EnsemblGenomes-Tr:CAB12545" /db_xref="GOA:Q797B3" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG12980" /db_xref="UniProtKB/Swiss-Prot:Q797B3" /translation="MKKLFSYKLSFFVLAVILFWAKTYLSYKTEFNLGVKGTTQEILL IFNPFSSAVFFLGLALLAKGRKSAIIMLIIDFLMTFVLYANILFYRFFDDFLTFPNIK QSGNVGNMGDGIFSIMAGHDIFYFLDIIILIAVLIWRPELKEYKMKKRFASLVILSGI ALFFINLHYAEKDRPQLLTRTFDRNYIVKYLGLYNYTIYDGVQTAQTETQRAYASSDD LTSVENYTTSHYAKPNAEYFGSAKGKNIIKIHLESFQSFLIDYKLNGEEVTPFLNKLA HGGEDVTYFDNFFHQTGQGKTSDAELTMDNSIFGLPEGSAFVTKGENTYQSLPAILDQ KEGYTSAVLHGDYKSFWNRDQIYKHIGYDKFFDASTYDMSDENVINMGLKDKPFFTES IPKLESLKQPFYAHLITLTNHYPFNLDEKDASLKKATTGDNTVDSYFQTARYLDEALE QFFKELKEAGLYDNSVIMIYGDHNGISENHNRAMKEILGKEITDYQNAQNQRVPLMIR VPGKKGGVNHTYGGEIDVMPTLLHLEGIDSQKYINFGTDLFSKDHDDTVAFRNGDFVT PKYTSVDNIIYDTKTGEKLKANEETKNLKTRVNQQLSLSDSVLYKDLLRFHKLNDFKA VDPSDYHYGKEKEIK*" gene 796314..798233 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" downshifts 798232 /Source="Nicolas_upshifts" /id="D357" /incds=0 /nref=103 /ntot=261 /MaxReadThrough="1.69168" /MaxDrop="7.8227" /score="37.7648461" /energy="-24" /TU="NA" /idTUdmin="U547" /TUdmin=2 /isTUend="TRUE" promotor_-35 798321..798330 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 798340..798468 /Source="Nicolas_S_feature" /locus_tag="new_798340_798468" /HighExp="BT, B36, S8, S7, G/S, Pyr, B60, S6, Glucon, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S251" upshifts 798340 /Source="Nicolas_upshifts" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" promotor_-10 798344..798363 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(798394) /Source="Nicolas_upshifts" /id="D358" /incds=0 /nref=2 /ntot=6 /MaxReadThrough="1.80969" /MaxDrop="4.63324" /score="20.6569889" /energy="-23.4" /TU="NA" /idTUdmin="U552" /TUdmin=4928 /isTUend="FALSE" CDS 798469..799233 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" /EC_number="2.7.7.33" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15634670, 16357223, 26577401" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15634670, 16357223, 26577401; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate cytidylyltransferase (sporulation)" /protein_id="NP_388608.1" /db_xref="EnsemblGenomes-Gn:BSU07270" /db_xref="EnsemblGenomes-Tr:CAB12546" /db_xref="GOA:O06486" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR013446" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12979" /db_xref="UniProtKB/Swiss-Prot:O06486" /translation="MKAVILCGGKGTRMSEVTNDIPKPLAMIGGKPILWHIMKIYQYY GVNEFILLLGYKGEKIKEYFLDYEWKHNSLTLDSSTGEVQMLGQPETWKITFLETGVD TLTAGRILQAKDYIGDETFLLTYGDGLANINLFHLISYHQTKGAAATVTGIDKVSQFG TLTVEDGMAKTFSEKTSSDGIINGGFFVLSPKVFDYLPKDGNTMFEDEPLKNLAKDGE LAVYRHYGFWTAIDTYKNLLEVNKMWNQGQQVWKVW*" gene 798469..799233 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" CDS 799240..800208 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CDP-sugar-dehydratase/epimerase" /protein_id="NP_388609.2" /db_xref="EnsemblGenomes-Gn:BSU07280" /db_xref="EnsemblGenomes-Tr:CAB12547" /db_xref="GOA:O06485" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12978" /db_xref="UniProtKB/Swiss-Prot:O06485" /translation="MSFWKNKNVFVTGCTGLLGSYLVKELIEQGANVTGLVRDHVPQS NLYQGEHIKKMNIVRGSLEDLAVIERALGEYEIDTVFHLAAQAIVGVANRNPISTFEA NILGTWNILEACRKHPLIKRVIVASSDKAYGDQENLPYDENMPLQGKHPYDVSKSCAD LISHTYFHTYGLPVCITRCGNLYGGGDLNFNRIIPQTIQLVLNGEAPEIRSDGTFVRD YFYIEDAVQAYLLLAEKMEENNLAGEAFNFSNEIQLTVLELVEKILKKMNSNLKPKVL NQGSNEIKHQYLSAEKARKLLNWTPAYTIDEGLEKTIEWYTEFFKK*" gene 799240..800208 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" CDS 800232..801143 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_388610.1" /db_xref="EnsemblGenomes-Gn:BSU07290" /db_xref="EnsemblGenomes-Tr:CAB12548" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12977" /db_xref="UniProtKB/Swiss-Prot:O06484" /translation="MTSAYCTVLSKGRLYQAVALFKSLEQVDQDSPIFILCMDEDTHR VLQKLKMKQLNLVPVAALENELLLKLKETRDQSEYCWTMKPIFLQAVLNSNPELERVT YIDGDLFFYADPSPIFENQPDCSVLLSRGDIVIPSFEKEQIDMLQRLLGRYNSGFISF KHDDAGTDCLEWWKERCLEECKNAPGEGKFGDQGYLDYMSELFPNVCDITTPGVNIGH WNYGQHTFSWKDGRIVLEDGSPLIFYHFSGYRIVSINEIKQIHETTRTDLPFVHELYQ ETLPHIIQHMQTLDPEFNGFASKDDNK*" gene 800232..801143 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" promotor_-35 801021..801030 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 801043..801062 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 801046 /Source="Nicolas_upshifts" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" CDS 801172..802350 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388611.1" /db_xref="EnsemblGenomes-Gn:BSU07300" /db_xref="EnsemblGenomes-Tr:CAB12549" /db_xref="GOA:O06483" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12976" /db_xref="UniProtKB/Swiss-Prot:O06483" /translation="MKASVIIPAYNSKERLYNSLLSLNQQECDEEFEVIVADNGSEDG TLSMLESFQADFPLIFTRIKENRGIAYGRNQALRNARGDILIFHDSDMLAAKDLVAKH IKAHENEENLVVCGLFWKRIYSFYYERFEEEHKEQLAKLTGEMPKKDKQKLLEEADIK NGSFLDKSFDLDTDFIDVLKKILDEYGDDLKGYHMPWRFFITNNSSVKRKHVVDLGLF DEGIVRYGFEDYDLGIRLHQAGLTFRLRRDIVSVHQEHPSNCKSVDDIRANIAYMCDK YNNIRSLDVHLAFNGPFPPDMTNRIMADIQKLLESQKYDMLLNLFLELLHVVKERNID PDWRKKSPRVTAKSFDLQTVRKLLPKAKKKLGVNDFANALYALVNDLLHVDLRSLDVV *" gene 801172..802350 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" promotor_-35 801891..801897 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 801912..801931 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 801926 /Source="Nicolas_upshifts" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 802351..803286 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388612.1" /db_xref="EnsemblGenomes-Gn:BSU07310" /db_xref="EnsemblGenomes-Tr:CAB12550" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12975" /db_xref="UniProtKB/Swiss-Prot:O31542" /translation="MSTFHFSTIVSRTHIFKLMPMIHSLHEHCDDFHLYVLCVDQKAY ELLQHVPWEHVTFVQLHEMEDPELLKAKSNRTFHEYCWTLKPAFLFHVMSKWDDAEYF AHMDTDLFFFSDPARIFAENPTASLYLTDHRNSPRFMSYYDRTGRFNTGFVGAGNTKE AYEAVWQWRQDCIEFCTVEMDTERKTYGDQRYVEKWPEQFKGVHVVKSIGANTALWNI ENYKVGQKDGRVYIDETPLIFYHFSGFTLVTEKEFNLCWYYRIEDEATIKMIYMPYIL NLKRWIDEIQSAFPDFADGFIPKHAVPDTHFIQLD*" gene 802351..803286 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" downshifts 803158 /Source="Nicolas_upshifts" /id="D359" /incds=1 /nref=1 /ntot=52 /MaxReadThrough="5.41459" /MaxDrop="2.6465" /score="34.8532284" /energy="-15.2" /TU="U549,U550" /idTUdmin="U549" /TUdmin="-110" /isTUend="FALSE" downshifts 803268 /Source="Nicolas_upshifts" /id="D360" /incds=0 /nref=2 /ntot=30 /MaxReadThrough="2.32849" /MaxDrop="5.65066" /score="34.8532284" /energy="-15.2" /TU="NA" /idTUdmin="U549" /TUdmin=0 /isTUend="TRUE" downshifts complement(803309) /Source="Nicolas_upshifts" /id="D361" /incds=0 /nref=158 /ntot=249 /MaxReadThrough="1.15199" /MaxDrop="4.97014" /score="32.9697757" /energy="-15.2" /TU="NA" /idTUdmin="U552" /TUdmin=13 /isTUend="TRUE" CDS complement(803317..804546) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388613.1" /db_xref="EnsemblGenomes-Gn:BSU07320" /db_xref="EnsemblGenomes-Tr:CAB12551" /db_xref="GOA:O06481" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12974" /db_xref="UniProtKB/Swiss-Prot:O06481" /translation="MAIAAPLKEKTVQKPGTTVYPILIIIGICHMLNDSLQAVIPAMF PILERSMSLTFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPVGLTASMLGILG LAFAPSFITILCCVFFIGLGSAIFHPEGSRVAYMAAGTKRGLAQSIYQVGGNSGQAMA PLITALILVPLGQFGAVWFTLVAALAVMFLMYIAKWYASRLGSLAQKSGKQKKTAENT AITKSVVSALIIIIFLIFARSWYTSAIGNFYTFYAMDTYHVSIQQAQSYIFVFLLFGA IGTFLGGPLADRFGKRFVILGSLLCSAPLAIVLPFAGPVLAYGVLALIGLVLMSSFSV TVVYAQELVPGKIGTMSGLTVGLAFGMGAIGAVALGALIDAAGLTPTMIAIAFLPVLG ILAFLLPSDQKLREWHS*" gene complement(803317..804546) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" promotor_-10 complement(804575..804594) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(804593) /Source="Nicolas_upshifts" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" promotor_-35 complement(804610..804617) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(804657..805364) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine nucleotide phosphatase (promiscuous)" /protein_id="NP_388614.1" /db_xref="EnsemblGenomes-Gn:BSU07330" /db_xref="EnsemblGenomes-Tr:CAB12552" /db_xref="GOA:O06480" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR011951" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3ED5" /db_xref="PDB:3I76" /db_xref="SubtiList:BG12973" /db_xref="UniProtKB/Swiss-Prot:O06480" /translation="MKRYRTLLFDVDDTILDFQAAEALALRLLFEDQNIPLTNDMKAQ YKTINQGLWRAFEEGKMTRDEVVNTRFSALLKEYGYEADGALLEQKYRRFLEEGHQLI DGAFDLISNLQQQFDLYIVTNGVSHTQYKRLRDSGLFPFFKDIFVSEDTGFQKPMKEY FNYVFERIPQFSAEHTLIIGDSLTADIKGGQLAGLDTCWMNPDMKPNVPEIIPTYEIR KLEELYHILNIENTVSC*" gene complement(804657..805364) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" downshifts complement(804686) /Source="Nicolas_upshifts" /id="D362" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="2.75071" /MaxDrop="4.28644" /score="1.09492978" /energy="-15.7" /TU="NA" /idTUdmin="U553" /TUdmin=0 /isTUend="TRUE" misc_feature complement(805387..805406) /Source="Nicolas_upshift_promotors" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(805410) /Source="Nicolas_upshifts" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" CDS complement(805456..806841) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12022921, 15849754, 16850406, 17114254, 18632116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 15849754, 16850406, 17114254, 18632116; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methylthioribose permease" /protein_id="NP_388615.1" /db_xref="EnsemblGenomes-Gn:BSU07340" /db_xref="EnsemblGenomes-Tr:CAB12553" /db_xref="GOA:Q797A7" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12972" /db_xref="UniProtKB/Swiss-Prot:Q797A7" /translation="MSSLFRKKPLETLSAQSKSKSLARTLSAFDLTLLGIGCVIGTGI FVITGTVAATGAGPALIISFILAGLACALAAFCYAEFSSSIPISGSVYSYSYVTLGEL LAFLIGWDLMLEYVIALSAVATGWSSYFQSLLAGFNLHIPAALTGAPGSMAGAVFNLP AAVIILLITAIVSRGVKESTRFNNVIVLMKIAIILLFIIVGIGYVKPDNWSPFMPFGM KGVILSAATVFFAYLGFDAVSNASEEVKNPQKNMPVGIISALAVCTVLYIAVSLVLTG MMPYAKLNVGDPVSFALKFVGQDAVAGIISVGAIIGITTVMLALLYAQVRLTFAMSRD GLLPGLFAKVHPSFKTPFRNTWLTGIVAAGIAGFINLGTLAHLVNMGTLAAFTVISIA VIVLRKKHPEIKASFRVPFVPVVPIISAGICLWFMYSLPGVTWLSFVIWIAVGTLVYF LYSRKHSLLNK*" gene complement(805456..806841) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" downshifts complement(805478) /Source="Nicolas_upshifts" /id="D363" /incds=0 /nref=8 /ntot=91 /MaxReadThrough="3.68565" /MaxDrop="4.73728" /score="31.1617384" /energy="-15.4" /TU="U554" /idTUdmin="U554" /TUdmin="-770" /isTUend="FALSE" promotor_-10 complement(806890..806909) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(806907) /Source="Nicolas_upshifts" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" promotor_-35 complement(806924..806931) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 807009..807016 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 807024 /Source="Nicolas_upshifts" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" promotor_-10 807030..807048 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 807091..808548 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" /EC_number="1.2.1.67" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15033535, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vanillin dehydrogenase" /protein_id="NP_388616.1" /db_xref="EnsemblGenomes-Gn:BSU07350" /db_xref="EnsemblGenomes-Tr:CAB12554" /db_xref="GOA:O06478" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12971" /db_xref="UniProtKB/Swiss-Prot:O06478" /translation="MFQYEELNKQFIGGKWQEGSSPNVLENKNPYTQKTFTTFRKATA DDVDEAYRAAALAKKKWDAVNPFEKRTILEKAVTYIEENEEAIIYLIMEELGGTRLKA AFEIGLVKNIIKEAATFPIRMEGKILPSTIDGKENRLYRVPAGVVGVISPFNFPFFLS MKSVAPALGAGNGVVLKPHEETPICGGTLIAKIFENAGIPAGLLNVVVTDIAEIGDSF VEHPVPRIISFTGSTKVGSYIGQLAMKHFKKPLLELGGNSAFIVLEDADIEYAVNAAV FSRFTHQGQICMSANRVLVHSSIYDKFLELYQAKVESLKVGDPMDPDTIIGPLINSRQ TDGLMKTVEQAIEEGAVPVKLGGFNGTIVEPTILKDVKPFMSIAKEELFGPVVSFMKF DSEDEAVDIANETPFGLSGAVHTSNLERGVAFAKRIETGMIHVNDTTINDEPNVAFGG EKQSGLGRLNGEWSLEEFTTLKWISVQHEKRSFPY*" gene 807091..808548 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" promotor_-10 complement(807884..807903) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(807898) /Source="Nicolas_upshifts" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(807916..807925) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 808562..809422 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="chemotaxis sensory transducer (sensed target unknown)" /protein_id="NP_388617.1" /db_xref="EnsemblGenomes-Gn:BSU07360" /db_xref="EnsemblGenomes-Tr:CAB12555" /db_xref="GOA:O06477" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="SubtiList:BG12970" /db_xref="UniProtKB/Swiss-Prot:O06477" /translation="MELTINTEKETADILDAFIKVAPYLNSLVQDDITIGIYDTEKLL VNIPAKTFSLNVKAGDPLQEGDIITDAIRSNQKKTSMVPKELFGFPLIARAIPLHDEN GRVIGGVGLGTSLEESSKLHDVAESLSAVVEQTAAAISDISESINGFSTQMSGISSQA KKVSESAGEIADISVTVKGISDQSNLLGLNAAIEAARAGESGKGFSVVADEIRKLATH SKENVGQIDQITKKIHSLLKGLEESIESINQHTDGQAAAVEQISATMQEISGSAQHLA KMAEKALEEE*" gene 808562..809422 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" downshifts 809406 /Source="Nicolas_upshifts" /id="D364" /incds=0 /nref=208 /ntot=237 /MaxReadThrough="2.9987" /MaxDrop="6.02377" /score="31.9989755" /energy="-16.7" /TU="U555" /idTUdmin="U555" /TUdmin="-22" /isTUend="TRUE" promotor_-35 809490..809497 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 809511..809530 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 809516 /Source="Nicolas_upshifts" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" CDS 809557..811446 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" /EC_number="3.6.3.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10715006, 16109936, 18848624, 19948254, 24389465, 24389466; Product type r : regulator" /codon_start=1 /transl_table=11 /product="putative energy-dependent translational throttleA" /protein_id="NP_388618.1" /db_xref="EnsemblGenomes-Gn:BSU07370" /db_xref="EnsemblGenomes-Tr:CAB12556" /db_xref="GOA:O06476" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12969" /db_xref="UniProtKB/Swiss-Prot:O06476" /translation="MSILKAENLYKTYGDKTLFDHISFHIEENERIGLIGPNGTGKST LLKVIAGLESIEEGEITKSGSVQVEFLHQDPELPAGQTVLEHIYSGESAVMKTLREYE KALYELGKDPENEQRQKHLLAAQAKMDANNAWDANTLAKTVLSKLGVNDVTKPVNELS GGQKKRVAIAKNLIQPADLLILDEPTNHLDNETIEWLEGYLSQYPGAVMLVTHDRYFL NRVTNRIYELERGSLYTYKGNYEVFLEKRAEREAQAEQKETKRQNLLRRELAWLRRGA KARSTKQKARIDRVETLKEQTGPQSSGSLDFAIGSHRLGKQVIEAENVMIAYDGRMLV DRFNELVIPGERIGIIGPNGIGKTTLLNALAGRHTPDGGDITIGQTVRIGYYTQDHSE MNGELKVIDYIKETAEVVKTADGDMITAEQMLERFLFPRSMQQTYIRKLSGGEKRRLY LLQVLMQEPNVLFLDEPTNDLDTETLSVLEDYIDQFPGVVITVSHDRYFLDRVVDRLI VFEGNGVISRFQGSYSDYMEESKAKKAAPKPAAEEKTAEAEPKKKRKKLSYKDQLEWD GIEDKIAQLEEKHEQLEADIAAAGSDFGKIQELMAEQAKTAEELEAAMDRWTELSLMI EELES*" gene 809557..811446 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" downshifts 811430 /Source="Nicolas_upshifts" /id="D365" /incds=0 /nref=2 /ntot=134 /MaxReadThrough="2.98669" /MaxDrop="2.72484" /score="30.3267801" /energy="-13.8" /TU="U557" /idTUdmin="U557" /TUdmin="-572" /isTUend="FALSE" misc_feature 811510..811529 /Source="Nicolas_upshift_promotors" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 811518 /Source="Nicolas_upshifts" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" CDS 811569..812015 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26483775" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388619.1" /db_xref="EnsemblGenomes-Gn:BSU07380" /db_xref="EnsemblGenomes-Tr:CAB12557" /db_xref="GOA:O06475" /db_xref="InterPro:IPR019723" /db_xref="SubtiList:BG12968" /db_xref="UniProtKB/Swiss-Prot:O06475" /translation="MTWAIVMLILMSLVKIVLTCLPTGVIEWLLGKFEVHAKLSDENA SLSLDGKRLEGAEKQKVIDQFNEAIFLEKYYIYPGDEERYLHPENGGTPLVIDTKKGK KDVKLFVYRYDDHIDVVKQYKKKVIAYRVLSESLQKESLSVAGSLA*" gene 811569..812015 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" downshifts complement(811571) /Source="Nicolas_upshifts" /id="D366" /incds=0 /nref=48 /ntot=154 /MaxReadThrough="1.16717" /MaxDrop="4.57866" /score="0.689181271" /energy="-10.2" /TU="NA" /idTUdmin="U559" /TUdmin=1 /isTUend="TRUE" promotor_-10 complement(811655..811658) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(811660) /Source="Nicolas_upshifts" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(811676..811677) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 812002 /Source="Nicolas_upshifts" /id="D367" /incds=0 /nref=254 /ntot=267 /MaxReadThrough="3.12706" /MaxDrop="7.87026" /score="13.6774886" /energy="-8" /TU="U558" /idTUdmin="U557" /TUdmin=0 /isTUend="TRUE" promotor_-35 812078..812085 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 812099..812118 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 812111 /Source="Nicolas_upshifts" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" CDS 812140..812562 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family) of metal(copper) efflux transporter expression" /protein_id="NP_388620.1" /db_xref="EnsemblGenomes-Gn:BSU07390" /db_xref="EnsemblGenomes-Tr:CAB12558" /db_xref="GOA:O06474" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG12967" /db_xref="UniProtKB/Swiss-Prot:O06474" /translation="MEWMKIDQVAKRSGLTKRTIRFYEEIGLIPAPKRTDGGVRLYSE DDMEELEKVISTKEVLGFSLQELQHFMETSRQLELNKEGYLLSLDPKERKEKLEEIQE TLNHQLDLIDEKIRTFQSFKERLQGMKGKAERAIQSIE*" gene 812140..812562 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" downshifts 812398 /Source="Nicolas_upshifts" /id="D368" /incds=1 /nref=2 /ntot=135 /MaxReadThrough="4.24358" /MaxDrop="2.69696" /score="13.6774886" /energy="-8" /TU="U560" /idTUdmin="U558" /TUdmin=308 /isTUend="FALSE" CDS 812628..813818 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14663075, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="metal (copper) efflux transporter" /protein_id="NP_388621.1" /db_xref="EnsemblGenomes-Gn:BSU07400" /db_xref="EnsemblGenomes-Tr:CAB12559" /db_xref="GOA:O06473" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12966" /db_xref="UniProtKB/Swiss-Prot:O06473" /translation="MDKTTQVNQKTGLLSQPKAVWAVAFACVISFMGIGLVDPILPAI AAQLHASPSEVSLLFTSYLLVTGFMMFFSGAISSRIGAKWTLILGLIFIIVFAGLGGS SSSIAQLVGYRGGWGLGNALFISTALAVIVGVSVGGSAQAIILYEAALGLGISVGPLA GGELGSISWRAPFFGVSVLMFIALIAISFMLPKLPKPAKRVGVFDAMKALKYKGLLTM AVSAFLYNFGFFILLAYSPFVLDLDEHGLGYVFFGWGLLLAITSVFTAPLVHKALGTV RSLVVLFIAFAAILVIMGIWTDHQTLIITCIVVAGAVLGMVNTIMTTAVMGSAPVERS IASSAYSSVRFIGGALAPWIAGMLSEHFTASTPYTVGGIVVFVGMLVLLMGRKHLAGI KAGH*" gene 812628..813818 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" downshifts complement(813882) /Source="Nicolas_upshifts" /id="D369" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="-0.0437700000000003" /MaxDrop="2.92105" /score="-8.93016606" /energy="-11.6" /TU="NA" /idTUdmin="U562" /TUdmin=528 /isTUend="FALSE" CDS 814109..814264 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388622.1" /db_xref="EnsemblGenomes-Gn:BSU07410" /db_xref="EnsemblGenomes-Tr:CAB12560" /db_xref="SubtiList:BG12965" /db_xref="UniProtKB/Swiss-Prot:O06472" /translation="MDKAKPDEYDQKCLETLYQYIHSVMKNSFSRSSGLPLGKMRRIL SCLPKES*" gene 814109..814264 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" CDS complement(814384..815940) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" /EC_number="3.6.3.-" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 16109936, 16684363, 22333191, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388623.2" /db_xref="EnsemblGenomes-Gn:BSU07420" /db_xref="EnsemblGenomes-Tr:CAB12571" /db_xref="GOA:O34512" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12964" /db_xref="UniProtKB/Swiss-Prot:O34512" /translation="MSILSVKDLSHGFGDRAIFNNVSFRLLKGEHVGLIGANGEGKST FMNIITGKLEPDEGKVEWSKNVRVGYLDQHTVLEKGKSIRDVLKDAFHYLFAMEEEMN EIYNKMGEADPDELEKLLEEVGVIQDALTNNDFYVIDSKVEEIARGLGLSDIGLERDV TDLSGGQRTKVLLAKLLLEKPEILLLDEPTNYLDEQHIEWLKRYLQEYENAFILISHD IPFLNSVINLIYHVENQELTRYVGDYHQFMEVYEVKKQQLEAAYKKQQQEVAELKDFV ARNKARVSTRNMAMSRQKKLDKMDMIELAAEKPKPEFHFKPARTSGKLIFETKDLVIG YDSPLSRPLNLRMERGQKIALYGANGIGKTTLLKSLLGEIQPLEGSVERGEHIYTGYF EQEVKETNNNTCIEEVWSEFPSYTQYEIRAALAKCGLTTKHIESRVSVLSGGEKAKVR LCKLINSETNLLVLDEPTNHLDADAKEELKRALKEYKGSILLISHEPDFYMDIATETW NCESWTTKVL*" gene complement(814384..815940) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" downshifts complement(814408) /Source="Nicolas_upshifts" /id="D370" /incds=0 /nref=173 /ntot=264 /MaxReadThrough="0.35675" /MaxDrop="5.82627" /score="21.7805812" /energy="-12" /TU="NA" /idTUdmin="U562" /TUdmin=2 /isTUend="TRUE" promotor_-35 815770..815776 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 815791..815802 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 815808 /Source="Nicolas_upshifts" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" promotor_-10 complement(815990..816009) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(815994) /Source="Nicolas_upshifts" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" promotor_-35 complement(816025..816029) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 816050..816053 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 816069..816088 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 816072 /Source="Nicolas_upshifts" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" CDS 816113..817243 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11976317; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_388624.1" /db_xref="EnsemblGenomes-Gn:BSU07430" /db_xref="EnsemblGenomes-Tr:CAB12572" /db_xref="GOA:O34750" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12963" /db_xref="UniProtKB/Swiss-Prot:O34750" /translation="MTQTWPFLHNAQSFIQENWNASGFQKPTPVQEQAAQLIMDGKDV IAESPTGTGKTLAYALPVLERIKPEQKHPQAVILAPSRELVMQIFQVIQDWKAGSELR AASLIGGANVKKQVEKLKKHPHIIVGTPGRVFELIKAKKLKMHEVKTIVLDETDQLVL PEHRETMKQIIKTTLRDRQLLCFSATLKKETEDVLRELAQEPEVLKVQRSKAEAGKVK HQYLICDQRDKVKLLQKLSRLEGMQALVFVRDIGNLSVYAEKLAYHHVELGVLHSEAK KMERAKIIATFEDGEFPLLLATDIAARGLDIENLPYVIHADIPDEDGYVHRSGRTGRA GKEGNVLSLVTKLEESKLKKMAKKLGVELSEAVYAGGKLKTK*" gene 816113..817243 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" downshifts 817226 /Source="Nicolas_upshifts" /id="D371" /incds=0 /nref=43 /ntot=133 /MaxReadThrough="2.93747" /MaxDrop="4.41385" /score="23.4253604" /energy="-5.9" /TU="NA" /idTUdmin="U563" /TUdmin="-12" /isTUend="TRUE" CDS 817311..817757 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388625.1" /db_xref="EnsemblGenomes-Gn:BSU07440" /db_xref="EnsemblGenomes-Tr:CAB12573" /db_xref="GOA:O34536" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12962" /db_xref="UniProtKB/Swiss-Prot:O34536" /translation="MASIDRFQVMQEPELKILEHWFENEDTRRRMDGMLLLDEWYARV NKDKHDTVIMAYDGQLPAGMVVIEFGEERTYIGLIVNPLYRLKGYGKQILQKLMTEPD FTSVREWVACIEEDNRISLACFQAAGFTLEDTEPDEDGFLTLILRN*" gene 817311..817757 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" CDS complement(817810..818829) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388626.1" /db_xref="EnsemblGenomes-Gn:BSU07450" /db_xref="EnsemblGenomes-Tr:CAB12574" /db_xref="GOA:O34812" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12961" /db_xref="UniProtKB/Swiss-Prot:O34812" /translation="MTASQQQIQLARRPQGIPVHEDFRFETIPVPEPKQGEVLVKTLY VSVDPYMRGRMQDTKSYVEPFALDKALSGGVIAEVVSDGNHLKKGDIVIGNLSWQEFS AVSESALRKIDTSLAPASAYLGILGMTGLTAYFGLLDIGRPKEGETVVVSGAAGAVGS TVGQIAKIKGARVVGIAGSDEKIDYLKQELQFDEAINYKTADDIQKALQNACPDGVDV YFDNVGGPISDAVMNLLNEFARIPVCGAISSYNAESEADDMGPRVQSKLIKTKSLMQG FIVSDYSDRFSEGAKQLAEWLKAGKLHYEETITEGFENIPDAFLGLFKGENKGKQLIK VSDPS*" gene complement(817810..818829) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" downshifts complement(817820) /Source="Nicolas_upshifts" /id="D372" /incds=0 /nref=183 /ntot=252 /MaxReadThrough="2.26899" /MaxDrop="5.73395" /score="20.8047206" /energy="-12.8" /TU="NA" /idTUdmin="U564" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(818850..818869) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(818854) /Source="Nicolas_upshifts" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" S_feature complement(818856..819310) /Source="Nicolas_S_feature" /locus_tag="new_818856_819310_c" /HighExp="S2, S1, Pyr, T4.0H, T0.0H, T-2.40H, T3.30H, T-1.40H, T-0.40H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S252" promotor_-35 complement(818882..818889) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 818948..818955 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 818969..818988 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 818976..820073 /Source="Nicolas_S_feature" /locus_tag="new_818976_820073" /HighExp="Etha, dia5, Diami, C30, dia15, T5.0H, S8, T3.0H, M0t90, LPhT" /AntisenseName="yfmI" /AntisenseCor="0.135213889213362" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S253" upshifts 818976 /Source="Nicolas_upshifts" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" CDS complement(819311..820531) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388627.1" /db_xref="EnsemblGenomes-Gn:BSU07460" /db_xref="EnsemblGenomes-Tr:CAB12575" /db_xref="GOA:O34440" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12960" /db_xref="UniProtKB/Swiss-Prot:O34440" /translation="MSKGYYSILFSQTTTNLGFSLYTMVVISFLFKMTNSTTIASMVT LISIIFRIFGSAILPLITIRLKLPLTIIISQLIQMLLLICLFYALLRTYSNQTLILVF IIISCISFFNGWFSPLKSAIIGEIISPDRRVKANGLLSTVDQTFQFVGWSLGGLIIAF LGEGYTIILTIFLLFTSLLSLLFCLPHGHANSVIREKNSPNKSIVSGWRYLFSQKKLR TIIIMDLIESWAGMIWIGSVSLAFVNEVLHKGESWWGFINGAYYLGSMIGGFIIYKLS ERFQNKLINFMLIGAVSYGSLTLIYGFISNSYLALILVLFMGPAYILRDLTQETLIQN ITTEQTRINIMSARSSLVQFIFMFSILAIGAISDFLGVRLVYVSAGILLLVSAIYGFS QLQFKKKVNKHISF*" gene complement(819311..820531) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" promotor_-10 complement(820568..820587) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(820575) /Source="Nicolas_upshifts" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" promotor_-35 complement(820603..820610) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 820629..820636 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 820648..820823 /Source="Nicolas_S_feature" /locus_tag="new_820648_820823" /HighExp="LoTm, T-1.10H, T-0.40H, S3, M9-stat, T0.0H, T-1.40H, BC, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.98260400000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S254" upshifts 820648 /Source="Nicolas_upshifts" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" promotor_-10 820651..820670 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 820780 /Source="Nicolas_upshifts" /id="D373" /incds=0 /nref=34 /ntot=117 /MaxReadThrough="8.67835" /MaxDrop="8.45742" /score="4.02328636" /energy="-13.7" /TU="U567" /idTUdmin="U565" /TUdmin=748 /isTUend="FALSE" CDS 820867..822330 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388629.1" /db_xref="EnsemblGenomes-Gn:BSU07480" /db_xref="EnsemblGenomes-Tr:CAB12577" /db_xref="InterPro:IPR005532" /db_xref="InterPro:IPR016187" /db_xref="SubtiList:BG12958" /db_xref="UniProtKB/Swiss-Prot:O34722" /translation="MTLLMQDHKSIYNKDIEILIEVEELITSVPENKKNDFKSLIDNR IMTLLNKIQHPVAAENVFGMCIAYPNTYIRYRLIDFVEKWVPYFSAVETIINLTQDPD DLVSFKAMDVCANHKIEESVAYLSSIIDDVRESISYPKKPVGLGAQKVLSTLLDIFGV EKHEELVMLKNYFDQNGILPNNFDFEEKIPQSLIEEFEKTEEDGMILIPGGFFEFGLN ENEIPDKTFNWKDAVPRQKVWLPPFFIDKYPVTNKDYDIFTEFIEENGHIFCHPNEPQ NKQHRRNTYWDDRYLDNHPVTGIDFYDAFAYARYKGKELPTEFQWEKAARGEKGNVWP WGDKFDPAKVQYAGSLYNEPITSLKSWRENLLKAHADKELNHLTSDIFEQNGESPYGV CGMIGGTWEWTRSELKTKRAFHPIFENVPFNSVNSFAVLKGGSFFSHPGLMFPSFRAK DIPFCRHNEMGIRCVKNIPVYKIRESINGPITNKAIY*" gene 820867..822330 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" S_feature complement(821232..822902) /Source="Nicolas_S_feature" /locus_tag="new_821232_822902_c" /HighExp="H2O2, C30, Salt, Lbstat, dia15, LPhT, dia5, Paraq, HiOs, Diami" /AntisenseName="yfmG" /AntisenseCor="-0.58045119682782798" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S255" S_feature 822331..822824 /Source="Nicolas_S_feature" /locus_tag="new_822331_822824" /HighExp="LoTm, T0.0H, T-1.40H, T-0.40H, T-2.40H, T-1.10H, Pyr, T-3.40H, SMMPr, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S256" promotor_-35 822812..822817 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 822826..826091 /Source="Nicolas_S_feature" /locus_tag="new_822826_826091" /HighExp="LoTm, Pyr, B36, T3.30H, T2.0H, T-0.40H, T2.30H, B60, T4.0H, T3.0H" /AntisenseName="yfmE" /AntisenseCor="-0.61640022790163695" /AntisenseRegPval="-28.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.982, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S257" upshifts 822826 /Source="Nicolas_upshifts" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" promotor_-10 822833..822851 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(822903..823703) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16672620, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (ATP-binding protein)" /protein_id="NP_388630.1" /db_xref="EnsemblGenomes-Gn:BSU07490" /db_xref="EnsemblGenomes-Tr:CAB12578" /db_xref="GOA:O34510" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12957" /db_xref="UniProtKB/Swiss-Prot:O34510" /translation="MGKLAADQLTLSYDSTVIIDGVDLKIEEGKITALIGANGCGKST ILKSLARLMAPKSGTVLLEGKDIHRQPSKEVAKKLAILPQSPQAPEGLTVEELCYFGR HPHKKLLSKHTQEDHDMVEWALEATGMIELKDRTLDALSGGQRQRAWISMALAQGTDL LLLDEPTTYLDISHQIEVLELLKKLNRDHGRTVVMVLHDLNQAAQYADYLISVLDGKI YNAGTPEDVFTQPFFREVFGLECCIMRSPIDQKPMCLPTGLCPKLRAK*" gene complement(822903..823703) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" CDS complement(823716..824717) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16672620, 16850406, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388631.1" /db_xref="EnsemblGenomes-Gn:BSU07500" /db_xref="EnsemblGenomes-Tr:CAB12579" /db_xref="GOA:O34832" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12956" /db_xref="UniProtKB/Swiss-Prot:O34832" /translation="MKKTTRKQKRPLLAILILAVILIVLSVISIGIGALYISPDAVVT NLLGLDHSFEFIIQQYRLPRIILAILAGAGLAAAGAILQGVIRNPLASPDVVGISKGS GLAAMAVILIFPESPVYVLPFSAFAGAAIIAVLLLMIARKKSIQPSSLALSGIALGAV CHAGMQYMMVKFPGDVNAALIWLTGSLWGRNWEEVKLLAPWLLILFPIVCILIPKLDL MSLGDELAQGLGENANRLRFILIFTAVALAGSCVAVVGSIGFIGLLAPHIARRLTGEK AKYLLPASALIGAIILLIADTLGRGIMPPVEIPAGILTAVIGAPYFLYLLKFEARKQ* " gene complement(823716..824717) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" promotor_-10 complement(824303..824322) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(824315) /Source="Nicolas_upshifts" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" promotor_-35 complement(824337..824344) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(824714..825715) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388632.1" /db_xref="EnsemblGenomes-Gn:BSU07510" /db_xref="EnsemblGenomes-Tr:CAB12580" /db_xref="GOA:O34933" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12955" /db_xref="UniProtKB/Swiss-Prot:O34933" /translation="MYHSAKRRSSSRLMMFIIALIIFIFGLGLNLSVGASDISIIDSL KYLFVWDGSKEQLIISTLRLPRTLIGVFVGASLAVAGALMQAMTRNPLASPQIFGVNA GASLFVVASLVILPASPYSSVIFAFAGAAAGGAIVYMIASSGGMTPVKLALSGMAVHL FLSSMTQAIIILNESGEDVLYWMTGAIDGSNWQDVITIAPFSVIGIGLALVFSGSVSV LGLGDETAKGLGQNMNGIRILISLIILILSGASVAVAGPIGFVGLLVPHIVRKLIGEH YQYVLPFSALFGAILLVYADVLARWIAFPYESPVGIVTAIIGTPFFLYLARKGRNLK* " gene complement(824714..825715) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" misc_feature complement(825785..825804) /Source="Nicolas_upshift_promotors" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(825787..826734) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (binding lipoprotein)" /protein_id="NP_388633.1" /db_xref="EnsemblGenomes-Gn:BSU07520" /db_xref="EnsemblGenomes-Tr:CAB12581" /db_xref="GOA:O34348" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12954" /db_xref="UniProtKB/Swiss-Prot:O34348" /translation="MRTYSNKLIAIMSVLLLACLIVSGCSSSQNNNGSGKSESKDSRV IHDEEGKTTVSGTPKRVVVLELSFLDAVHNLGITPVGIADDNKKDMIKKLVGSSIDYT SVGTRSEPNLEVISSLKPDLIIADAERHKNIYKQLKKIAPTIELKSREATYDETIDSF TTIAKALNKEDEGKEKLAEHKKVINDLKAELPKDENRNIVLGVARADSFQLHTSSSYD GEIFKMLGFTHAVKSDNAYQEVSLEQLSKIDPDILFISANEGKTIVDEWKTNPLWKNL KAVKNGQVYDADRDTWTRFRGIKSSETSAKDVLKKVYNK*" gene complement(825787..826734) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" downshifts complement(825806) /Source="Nicolas_upshifts" /id="D374" /incds=0 /nref=41 /ntot=211 /MaxReadThrough="4.92983" /MaxDrop="4.53674" /score="-3.64310934" /energy="-13.9" /TU="U570,U573,U574" /idTUdmin="U570" /TUdmin="-198" /isTUend="FALSE" upshifts complement(825806) /Source="Nicolas_upshifts" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" promotor_-35 826061..826066 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 826082..826100 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 826093..826718 /Source="Nicolas_S_feature" /locus_tag="new_826093_826718" /HighExp="LoTm, B36, S5, S6, S4, S7, S8, S3, BT, B60" /AntisenseName="yfmC" /AntisenseCor="-0.52042999587715499" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S258" upshifts 826093 /Source="Nicolas_upshifts" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" misc_feature 826714..826733 /Source="Nicolas_upshift_promotors" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 826720..827251 /Source="Nicolas_S_feature" /locus_tag="new_826720_827251" /HighExp="LoTm, B36, S5, S4, S7, S6, S8, B60, S3, BT" /AntisenseName="yfmB" /AntisenseCor="-6.4915194654100006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.997, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S259" upshifts 826720 /Source="Nicolas_upshifts" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" promotor_-10 complement(826776..826795) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(826783) /Source="Nicolas_upshifts" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" promotor_-35 complement(826809..826816) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(826843..827211) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25651892" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388634.1" /db_xref="EnsemblGenomes-Gn:BSU07530" /db_xref="EnsemblGenomes-Tr:CAB12582" /db_xref="InterPro:IPR021579" /db_xref="PDB:2EUC" /db_xref="SubtiList:BG12953" /db_xref="UniProtKB/Swiss-Prot:O34626" /translation="MQYFSPEQQYNAWIVSDLVKQIFHKRAGCSPGIHELAVFAEEHF HIDIDFVFSIIMNIGDIEFALTDEIEKKLSGYLSTLLPYVTADMFETSKANAHAFLSR RHGNAAYHLFVSDDAFMRKQ*" gene complement(826843..827211) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" S_feature complement(827212..827324) /Source="Nicolas_S_feature" /locus_tag="new_827212_827324_c" /HighExp="Etha, BC, Sw, M9-stat, T3.30H, T1.30H, T3.0H, T5.0H, T2.30H, T2.0H" /AntisenseName="yfmA" /AntisenseCor="5.8024036419347599E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S260" promotor_-10 complement(827313..827332) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-10" upshifts complement(827324) /Source="Nicolas_upshifts" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" promotor_-35 complement(827344..827351) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-35" promotor_-35 827392..827398 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 827412..827430 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 827412 /Source="Nicolas_upshifts" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" CDS 827455..827802 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12089032; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heat stress induced protein" /protein_id="NP_388636.1" /db_xref="EnsemblGenomes-Gn:BSU07550" /db_xref="EnsemblGenomes-Tr:CAB12584" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG19020" /db_xref="UniProtKB/Swiss-Prot:P80241" /translation="MKPVVKEYTNDEQLMKDVEELQKMGVAKEDVYVLAHDDDRTERL ADNTNANTIGAKETGFKHAVGNIFNKKGDELRNKIHEIGFSEDEAAQFEKRLDEGKVL LFVTDNEKVKAWA*" gene 827455..827802 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" downshifts complement(827456) /Source="Nicolas_upshifts" /id="D375" /incds=0 /nref=6 /ntot=28 /MaxReadThrough="1.00082" /MaxDrop="4.87687" /score="-3.31058364" /energy="-3.6" /TU="NA" /idTUdmin="U570" /TUdmin="-1848" /isTUend="FALSE" downshifts 827798 /Source="Nicolas_upshifts" /id="D376" /incds=0 /nref=56 /ntot=197 /MaxReadThrough="6.41566" /MaxDrop="7.61596" /score="-1.88723414" /energy="-5.6" /TU="U575" /idTUdmin="U567" /TUdmin=0 /isTUend="TRUE" S_feature 827843..827923 /Source="Nicolas_S_feature" /locus_tag="new_827843_827923" /HighExp="Etha, Salt, B36, LoTm, Heat, B60, M9-stat, S8, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S261" misc_feature 827924..827943 /Source="Nicolas_upshift_promotors" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 827925 /Source="Nicolas_upshifts" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" CDS 827993..829255 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8262178, 12823818, 27447541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8262178, 12823818, 27447541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pectate lyase" /protein_id="NP_388637.1" /db_xref="EnsemblGenomes-Gn:BSU07560" /db_xref="EnsemblGenomes-Tr:CAB12585" /db_xref="GOA:P39116" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="PDB:1BN8" /db_xref="PDB:2BSP" /db_xref="PDB:2NZM" /db_xref="PDB:2O04" /db_xref="PDB:2O0V" /db_xref="PDB:2O0W" /db_xref="PDB:2O17" /db_xref="PDB:2O1D" /db_xref="PDB:3KRG" /db_xref="PDB:5AMV" /db_xref="SubtiList:BG10840" /db_xref="UniProtKB/Swiss-Prot:P39116" /translation="MKKVMLATALFLGLTPAGANAADLGHQTLGSNDGWGAYSTGTTG GSKASSSNVYTVSNRNQLVSALGKETNTTPKIIYIKGTIDMNVDDNLKPLGLNDYKDP EYDLDKYLKAYDPSTWGKKEPSGTQEEARARSQKNQKARVMVDIPANTTIVGSGTNAK VVGGNFQIKSDNVIIRNIEFQDAYDYFPQWDPTDGSSGNWNSQYDNITINGGTHIWID HCTFNDGSRPDSTSPKYYGRKYQHHDGQTDASNGANYITMSYNYYHDHDKSSIFGSSD SKTSDDGKLKITLHHNRYKNIVQRAPRVRFGQVHVYNNYYEGSTSSSSYPFSYAWGIG KSSKIYAQNNVIDVPGLSAAKTISVFSGGTALYDSGTLLNGTQINASAANGLSSSVGW TPSLHGSIDASANVKSNVINQAGAGKLN*" gene 827993..829255 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" downshifts 829250 /Source="Nicolas_upshifts" /id="D377" /incds=0 /nref=139 /ntot=203 /MaxReadThrough="3.61256" /MaxDrop="5.92635" /score="1.82127533" /energy="-8.2" /TU="U575,U576" /idTUdmin="U576" /TUdmin="-176" /isTUend="FALSE" promotor_-35 829308..829311 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 829326..829345 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 829334 /Source="Nicolas_upshifts" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" CDS 829382..830818 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12949159, 15849754, 16850406, 25651892, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949159, 15849754, 16850406, 25651892, 28436820; Product type t : transporter" /codon_start=1 /transl_table=11 /product="malate (2-oxoglutarate) transporter" /protein_id="NP_388638.1" /db_xref="EnsemblGenomes-Gn:BSU07570" /db_xref="EnsemblGenomes-Tr:CAB12586" /db_xref="GOA:O34726" /db_xref="InterPro:IPR001898" /db_xref="InterPro:IPR030676" /db_xref="SubtiList:BG12951" /db_xref="UniProtKB/Swiss-Prot:O34726" /translation="MASEKDAGKQSAVKLVPLLITVAVGLIIWFIPAPSGLEPKAWHL FAIFVATIIGFISKPLPMGAIAIFALAVTALTGTLSIEDTLSGFGNKTIWLIVIAFFI SRGFIKTGLGARISYVFVQKFGKKTLGLSYSLLFSDLILSPAIPSNTARAGGIIFPII RSLSETFGSSPANGTERKIGAFLLKTGFQGNLITSAMFLTAMAANPLIAKLAHDVAGV DLTWTSWAIAAIVPGLVSLIITPLVIYKLYPPEIKETPDAAKIATEKLKEMGPFKKSE LSMVIVFLLVLVLWIFGGSFNIDATTTALIGLAVLLLSQVLTWDDIKKEQGAWDTLTW FAALVMLANFLNELGMVSWFSNAMKSSVSGFSWIVAFIILIVVYYYSHYFFASATAHI SAMYSAFLAVVVAAGAPPLLAALSLAFISNLFGSTTHYGSGAAPVFFGAGYIPQGKWW SIGFILSIVHIIVWLVIGGLWWKVLGIW*" gene 829382..830818 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" downshifts 830810 /Source="Nicolas_upshifts" /id="D378" /incds=0 /nref=56 /ntot=132 /MaxReadThrough="2.39993" /MaxDrop="5.36125" /score="40.3051497" /energy="-9.7" /TU="NA" /idTUdmin="U577" /TUdmin="-2" /isTUend="TRUE" misc_feature 830909..830928 /Source="Nicolas_upshift_promotors" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 830920 /Source="Nicolas_upshifts" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" CDS 830945..832573 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388639.1" /db_xref="EnsemblGenomes-Gn:BSU07580" /db_xref="EnsemblGenomes-Tr:CAB12587" /db_xref="GOA:O34427" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12576" /db_xref="UniProtKB/Swiss-Prot:O34427" /translation="MVKKRFHFSLQTKIMGLIAALLVFVIGVLTITLAVQHTQGERRQ AEQLAVQTARTISYMPPVKELIERKDGHAAQTQEVIEQMKEQTGAFAIYVLNEKGDIR SASGKSGLKKLERSREILFGGSHVSETKADGRRVIRGSAPIIKEQKGYSQVIGSVSVD FLQTETEQSIKKHLRNLSVIAVLVLLLGFIGAAVLAKSIRKDTLGLEPHEIAALYRER NAMLFAIREGIIATNREGVVTMMNVSAAEMLKLPEPVIHLPIDDVMPGAGLMSVLEKG EMLPNQEVSVNDQVFIINTKVMNQGGQAYGIVVSFREKTELKKLIDTLTEVRKYSEDL RAQTHEFSNKLYAILGLLELGEYDEAIDLIKEEYAIQNEQHDLLFHNIHSQQVQAILL GKISKASEKKVKLVIDENSSLAPLPAHIGLSHLITIIGNLIDNAFEAVAEQSVKEVLF FITDMGHDIVIEVSDTGPGVPPEKIEAVFERGYSSKGMRRGYGLANVKDSVRELGGWI ELANQKTGGAVFTVFIPKEKQRGNPFDSHRDCGG*" gene 830945..832573 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" CDS 832545..833225 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388640.1" /db_xref="EnsemblGenomes-Gn:BSU07590" /db_xref="EnsemblGenomes-Tr:CAB12588" /db_xref="GOA:O34534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR028141" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12577" /db_xref="UniProtKB/Swiss-Prot:O34534" /translation="MIHIAIAEDDFRVAQIHERLIKQLDGFKIIGKAANAKETLALLK EHKADLLLLDIYMPDELGTALIPDIRSRFPEVDIMIITAATETRHLQEALRAGIAHYL IKPVTADKFRQVLLQYKEKRKLLMSQPEVSQSMIDHIFGNGVKTALPAEDLPTGINSI TLRKIKEALQTASEGLTAEELGEKMGASRTTARRYAEYLVSKEEARAELEYGIIGRPE RKYYLAAD*" gene 832545..833225 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" CDS 833228..834187 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11029430; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative tricarboxylate transporter component" /protein_id="NP_388641.2" /db_xref="EnsemblGenomes-Gn:BSU07600" /db_xref="EnsemblGenomes-Tr:CAB12589" /db_xref="GOA:O34439" /db_xref="InterPro:IPR005064" /db_xref="SubtiList:BG12950" /db_xref="UniProtKB/Swiss-Prot:O34439" /translation="MKKSIILLNILLIFMQGDIRQAAAPRLPDGPIEIVVPAEPSGGW DVTAQAIQSVLRQKQIVKDDVHIVYKSGGGGEKGWKYVNKSSKQTISMTSSLILSNDL LGQSKLKMSDFTPLAILSKEWQTVALPKGSALTNGKDVLNEINMHPGKVRIGFAPGFG NDDQLSFVRAADMYGIDPFDIQFSQYDSSEQLIQALIRHEIEAASMTLSEAKPYERNG DITLAAVTSDKRLPGFPNVPTWKEQGIPFVFSHWRGILGPKNMSEEEISYWDQALKKV TSSPEWKRKINEQDWESFYLNSRETKRFLEEQSAFYQSIMTGN*" gene 833228..834187 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" downshifts 834156 /Source="Nicolas_upshifts" /id="D379" /incds=0 /nref=76 /ntot=211 /MaxReadThrough="1.1681" /MaxDrop="6.31244" /score="10.4510496" /energy="-6.5" /TU="NA" /idTUdmin="U578" /TUdmin=0 /isTUend="TRUE" promotor_-35 834279..834286 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 834299..834318 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 834310..834382 /Source="Nicolas_S_feature" /locus_tag="new_834310_834382" /HighExp="M9-stat, SMMPr, SMM, T0.0H, LoTm, T1.0H, Pyr, T1.30H, Cold, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S262" upshifts 834310 /Source="Nicolas_upshifts" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" CDS 834383..835684 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="transporter of divalent metal ions/citrate complexes" /protein_id="NP_388642.1" /db_xref="EnsemblGenomes-Gn:BSU07610" /db_xref="EnsemblGenomes-Tr:CAB12590" /db_xref="GOA:P55069" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11832" /db_xref="UniProtKB/Swiss-Prot:P55069" /translation="MLAILGFLMMLVFMALIMTKRLSVLTALVLTPIVFALIAGFGFT EVGDMMISGIQQVAPTAVMIMFAILYFGIMIDTGLFDPMVGKILSMVKGDPLKIVVGT AVLTMLVALDGDGSTTYMITTSAMLPLYLLLGIRPIILAGIAGVGMGIMNTIPWGGAT PRAASALGVDPAELTGPMIPVIASGMLCMVAVAYVLGKAERKRLGVIELKQPANANEP AAAVEDEWKRPKLWWFNLLLTLSLIGCLVSGKVSLTVLFVIAFCIALIVNYPNLEHQR QRIAAHSSNVLAIGSMIFAAGVFTGILTGTKMVDEMAISLVSMIPEQMGGLIPAIVAL TSGIFTFLMPNDAYFYGVLPILSETAVAYGVDKVEIARASIIGQPIHMLSPLVPSTHL LVGLVGVSIDDHQKFALKWAVLAVIVMTAIALLIGAISISV*" gene 834383..835684 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" promotor_-35 835681..835687 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 835701..835712 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 835702 /Source="Nicolas_upshifts" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" CDS 835740..836534 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10972810, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388643.1" /db_xref="EnsemblGenomes-Gn:BSU07620" /db_xref="EnsemblGenomes-Tr:CAB12591" /db_xref="GOA:O34409" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12949" /db_xref="UniProtKB/Swiss-Prot:O34409" /translation="MSDPYMPLTSVRSGAGFEAAKGVHGLTVQIANVYFIQLPSEPHS FVLIDAGMPQSAGVIVNEAKQRFGEGFQLKAIILTHGHFDHIGAIEEILEHWDVPVYI HSREMPYVTGKEDYPPARPDSKSGLVAKLSPLFPRHSIDISSHVQALPEDGSVPFLDE WMWIATPGHTPGHISLFRDDGRVLVAGDAVITVEQEKMADVLIQKQELHGPPAYFTPD TETAAESILKLAGLEPEALLTGHGIPMTGKNFRSDLTELANRLSSI*" gene 835740..836534 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" downshifts 836510 /Source="Nicolas_upshifts" /id="D380" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="0.0114999999999998" /MaxDrop="3.05232" /score="38.3109333" /energy="-11.8" /TU="NA" /idTUdmin="U580" /TUdmin=132 /isTUend="FALSE" promotor_-35 836589..836592 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 836607..836626 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 836620 /Source="Nicolas_upshifts" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" CDS 836653..837744 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" /EC_number="1.14.13.39" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11856757, 12220171, 16172391, 25643072, 25826316, 26062720" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11856757, 12220171, 16172391, 25643072, 25826316, 26062720; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nitric-oxide synthase" /protein_id="NP_388644.2" /db_xref="EnsemblGenomes-Gn:BSU07630" /db_xref="EnsemblGenomes-Tr:CAB12592" /db_xref="GOA:O34453" /db_xref="InterPro:IPR004030" /db_xref="InterPro:IPR017142" /db_xref="InterPro:IPR036119" /db_xref="PDB:1M7V" /db_xref="PDB:1M7Z" /db_xref="PDB:2AMO" /db_xref="PDB:2AN0" /db_xref="PDB:2AN2" /db_xref="PDB:2FBZ" /db_xref="PDB:2FC1" /db_xref="PDB:2FC2" /db_xref="PDB:4D3I" /db_xref="PDB:4D3J" /db_xref="PDB:4D3K" /db_xref="PDB:4D3M" /db_xref="PDB:4D3N" /db_xref="PDB:4D3O" /db_xref="PDB:4D3T" /db_xref="PDB:4D3U" /db_xref="PDB:4D3V" /db_xref="PDB:4D7H" /db_xref="PDB:4D7I" /db_xref="PDB:4D7J" /db_xref="PDB:4LWA" /db_xref="PDB:4LWB" /db_xref="PDB:4UG5" /db_xref="PDB:4UG6" /db_xref="PDB:4UG7" /db_xref="PDB:4UG8" /db_xref="PDB:4UG9" /db_xref="PDB:4UGA" /db_xref="PDB:4UGB" /db_xref="PDB:4UGC" /db_xref="PDB:4UGD" /db_xref="PDB:4UGE" /db_xref="PDB:4UGF" /db_xref="PDB:4UGG" /db_xref="PDB:4UGH" /db_xref="PDB:4UGI" /db_xref="PDB:4UGJ" /db_xref="PDB:4UGK" /db_xref="PDB:4UGL" /db_xref="PDB:4UGM" /db_xref="PDB:4UGN" /db_xref="PDB:4UGO" /db_xref="PDB:4UGP" /db_xref="PDB:4UGQ" /db_xref="PDB:4UGR" /db_xref="PDB:4UGS" /db_xref="PDB:4UGT" /db_xref="PDB:4UGU" /db_xref="PDB:4UGV" /db_xref="PDB:4UGW" /db_xref="PDB:4UGX" /db_xref="PDB:4UGY" /db_xref="PDB:4UQR" /db_xref="PDB:4UQS" /db_xref="PDB:5G65" /db_xref="PDB:5G66" /db_xref="PDB:5G67" /db_xref="PDB:5G68" /db_xref="PDB:5G69" /db_xref="PDB:5G6A" /db_xref="PDB:5G6B" /db_xref="PDB:5G6C" /db_xref="PDB:5G6D" /db_xref="PDB:5G6E" /db_xref="PDB:5G6F" /db_xref="PDB:5G6G" /db_xref="PDB:5G6H" /db_xref="PDB:5G6I" /db_xref="PDB:5G6J" /db_xref="PDB:5G6K" /db_xref="PDB:5G6L" /db_xref="PDB:5G6M" /db_xref="PDB:5G6N" /db_xref="PDB:5G6O" /db_xref="PDB:5G6P" /db_xref="PDB:5G6Q" /db_xref="SubtiList:BG12948" /db_xref="UniProtKB/Swiss-Prot:O34453" /translation="MEEKEILWNEAKAFIAACYQELGKEEEVKDRLADIKSEIDLTGS YVHTKEELEHGAKMAWRNSNRCIGRLFWNSLNVIDRRDVRTKEEVRDALFHHIETATN NGKIRPTITIFPPEEKGEKQVEIWNHQLIRYAGYESDGERIGDPASCSLTAACEELGW RGERTDFDLLPLIFRMKGDEQPVWYELPRSLVIEVPITHPDIEAFSDLELKWYGVPII SDMKLEVGGIHYNAAPFNGWYMGTEIGARNLADEKRYDKLKKVASVIGIAADYNTDLW KDQALVELNKAVLHSYKKQGVSIVDHHTAASQFKRFEEQEEEAGRKLTGDWTWLIPPI SPAATHIFHRSYDNSIVKPNYFYQDKPYE*" gene 836653..837744 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" CDS complement(837735..838010) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" /EC_number="3.6.1.7" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:20447399" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20447399; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphatase" /protein_id="NP_388645.1" /db_xref="EnsemblGenomes-Gn:BSU07640" /db_xref="EnsemblGenomes-Tr:CAB12593" /db_xref="GOA:O35031" /db_xref="InterPro:IPR001792" /db_xref="InterPro:IPR017968" /db_xref="InterPro:IPR020456" /db_xref="InterPro:IPR036046" /db_xref="PDB:2FHM" /db_xref="PDB:2HLT" /db_xref="PDB:2HLU" /db_xref="PDB:3BR8" /db_xref="SubtiList:BG12947" /db_xref="UniProtKB/Swiss-Prot:O35031" /translation="MLQYRIIVDGRVQGVGFRYFVQMEADKRKLAGWVKNRDDGRVEI LAEGPENALQSFVEAVKNGSPFSKVTDISVTESRSLEGHHRFSIVYS*" gene complement(837735..838010) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" S_feature 837745..838076 /Source="Nicolas_S_feature" /locus_tag="new_837745_838076" /HighExp="C90, BI, Paraq, LBGexp, Oxctl, M0t45, G150, M40t45, G135, H2O2" /AntisenseName="yflL" /AntisenseCor="0.38657275217332299" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S263" promotor_-10 complement(838024..838043) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(838038) /Source="Nicolas_upshifts" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" promotor_-35 complement(838058..838065) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 838077..838742 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11886751; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative sulfur carrier" /protein_id="NP_388646.1" /db_xref="EnsemblGenomes-Gn:BSU07650" /db_xref="EnsemblGenomes-Tr:CAB12594" /db_xref="GOA:O34542" /db_xref="InterPro:IPR005163" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="SubtiList:BG12946" /db_xref="UniProtKB/Swiss-Prot:O34542" /translation="MKQERYSVLSLNLGKPQTLEYDGKKIETGIMKRPAKSAVMLYRE NFEGDGQADLVNHGGPDKAVCVYPAEHYPFWEEFLSRPLSNAAFGENLTVAGLTEENV CIGDVFRLDEAVVQVSQPRQPCVKLAKKFGVKEMVLKVQQTGYTGFYFRVLEEGRVSP GANLELLSRGEKGISVQFANRINYHDAKNLTAIERILSEAALSESWRASFMKKKDRLL PVE*" gene 838077..838742 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" CDS complement(838783..838920) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388647.1" /db_xref="EnsemblGenomes-Gn:BSU07660" /db_xref="EnsemblGenomes-Tr:CAB12595" /db_xref="InterPro:IPR022580" /db_xref="SubtiList:BG12945" /db_xref="UniProtKB/Swiss-Prot:O34345" /translation="MHYGSKGWYVAELKKQGITHHEGRKLQSYKTYFLANLLESKKKQ S*" gene complement(838783..838920) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" downshifts complement(838797) /Source="Nicolas_upshifts" /id="D381" /incds=0 /nref=136 /ntot=260 /MaxReadThrough="0.0927600000000002" /MaxDrop="8.10929" /score="29.8336543" /energy="-14.8" /TU="NA" /idTUdmin="U583" /TUdmin="-11" /isTUend="TRUE" S_feature complement(838921..839051) /Source="Nicolas_S_feature" /locus_tag="new_838921_839051_c" /HighExp="S4, S7, S8, S6, S5, S3, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.967, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S264" promotor_-10 complement(839037..839055) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 839047..839052 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(839051) /Source="Nicolas_upshifts" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" S_feature 839062..840126 /Source="Nicolas_S_feature" /locus_tag="new_839062_840126" /HighExp="S8, S6, S5, S7, S4, S3, BT, B36, C90, T5.0H" /AntisenseName="mapB" /AntisenseCor="-0.26446079057314398" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S265" upshifts 839063 /Source="Nicolas_upshifts" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" promotor_-10 839068..839086 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(839071..839076) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(839077..839232) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388648.1" /db_xref="EnsemblGenomes-Gn:BSU07670" /db_xref="EnsemblGenomes-Tr:CAB12596" /db_xref="GOA:O34905" /db_xref="SubtiList:BG12944" /db_xref="UniProtKB/Swiss-Prot:O34905" /translation="MWFIIFGIIFFIEGIIMTVYGVKKKNGMLTYIGIVFAIMTFGVV MIKLTGH*" gene complement(839077..839232) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" S_feature complement(839233..839338) /Source="Nicolas_S_feature" /locus_tag="new_839233_839338_c" /HighExp="Etha, Salt, Diami, dia15, H2O2, Cold, G135, Paraq, LPhT, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S266" CDS complement(839339..839653) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1070366, 1266368; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388649.1" /db_xref="EnsemblGenomes-Gn:BSU07680" /db_xref="EnsemblGenomes-Tr:CAB12597" /db_xref="InterPro:IPR021637" /db_xref="PDB:3D0W" /db_xref="SubtiList:BG12943" /db_xref="UniProtKB/Swiss-Prot:O34306" /translation="MNRDQEKIQIENEMNAMHGTIKEDILKDFEEFKGYLKKQVNRGK KLGLDDGKLVKSAAILGDYLAKHEEPQNGEEMLLQELWSVADEDEKEHLAQLLVKLVD KQ*" gene complement(839339..839653) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" S_feature complement(839654..839734) /Source="Nicolas_S_feature" /locus_tag="new_839654_839734_c" /HighExp="dia5, dia15, Diami, LBGtran, LPhT, H2O2, Etha, Lbtran, M40t45, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S267" CDS complement(839735..840484) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase B" /protein_id="NP_388650.1" /db_xref="EnsemblGenomes-Gn:BSU07690" /db_xref="EnsemblGenomes-Tr:CAB12598" /db_xref="GOA:O34484" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG12942" /db_xref="UniProtKB/Swiss-Prot:O34484" /translation="MIVTNDQELEGLKKIGRIVALAREEMKRKAEPGMSTKDLDLIGK AVLDEHGAVSAPEKEYDFPGVTCISVNDEVAHGIPSTSKILKAGDLVNIDISAEFGGF YSDTGISFVLGEGEERLHKLCQCAENAFQKGLQQAKAGKRQNQIGRAVYHEARSQGFT VIKTLTGHGIGRSLHEAPNHIMNYYDPFDNALFKNGTVIALEPFISTKAETIVEAGDG WTFKTPDKSMVAQVEHTIVITKDEPIILTKL*" gene complement(839735..840484) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" promotor_-10 complement(840513..840532) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(840526) /Source="Nicolas_upshifts" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" S_feature complement(840528..841664) /Source="Nicolas_S_feature" /locus_tag="new_840528_841664_c" /HighExp="S6, S8, S7, S5, BT, C30, Paraq, B36, G180, Pyr" /AntisenseName="nagP" /AntisenseCor="0.180776000778922" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S268" promotor_-35 complement(840544..840552) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 840595..840596 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 840616..840635 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 840619 /Source="Nicolas_upshifts" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" CDS 840656..842014 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 8246840; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) N-acetylglucosamine-specific enzyme IICB component" /protein_id="NP_388651.1" /db_xref="EnsemblGenomes-Gn:BSU07700" /db_xref="EnsemblGenomes-Tr:CAB12599" /db_xref="GOA:O34521" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010974" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG12941" /db_xref="UniProtKB/Swiss-Prot:O34521" /translation="MLSFLQKLGKSFMLPIAVLPAVGIILALGREDVFNIPFVYQAGT AVFDHLPLIFAIGIAIGISKDSNGAAGLSGAISYLMLDAATKTIDKTNNMAVFGGIIA GLIAGYTYNRFKDTKLPEYLGFFSGRRLVPILTAIITIILAGIFGVVWPPIQSCINSF GEWMLGLGGIGAGIFGLFNRLLIPLGLHHVLNNIFWFQFGEYNGVTGDLARFFAKDPT AGTYMTGFFPIMMFGLPAACLAMVVTAKPSKRKATAGMMIGFALTAFITGITEPIEFA FMFLSPLLYAVHAVLTGLSLFIVNWLGIRSGFSFSAGAIDYVLSYGIAEKPLLLLLVG ICYAAVYFIVFYVLIKALNLKTPGREDDDVDEVLDENTVQDVNENIMLKGLGGKENLQ TIDHCATRLRLTVKDTALVDEALLKKAGAKGVVKSGGQSVQVIIGPNVEFAAEELRAA VK*" gene 840656..842014 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" promotor_-10 complement(841650..841669) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(841664) /Source="Nicolas_upshifts" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" promotor_-35 complement(841683..841692) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 841900 /Source="Nicolas_upshifts" /id="D382" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="3.67421" /MaxDrop="3.12268" /score="44.7832762" /energy="-16.9" /TU="U586" /idTUdmin="U586" /TUdmin="-88" /isTUend="FALSE" downshifts 842010 /Source="Nicolas_upshifts" /id="D383" /incds=0 /nref=2 /ntot=87 /MaxReadThrough="2.54331" /MaxDrop="3.17508" /score="44.7832762" /energy="-16.9" /TU="NA" /idTUdmin="U586" /TUdmin=22 /isTUend="TRUE" CDS complement(842047..843996) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10658653, 21255105" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658653, 21255105; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_388652.1" /db_xref="EnsemblGenomes-Gn:BSU07710" /db_xref="EnsemblGenomes-Tr:CAB12600" /db_xref="GOA:O34952" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="PDB:2W8D" /db_xref="SubtiList:BG12940" /db_xref="UniProtKB/Swiss-Prot:O34952" /translation="MKTFIKERGLAFFLIAVVLLWIKTYVGYVLNFNLGIDNTIQKIL LFVNPLSSSLFFLGFGLLFKKKLQQTAIIVIHFLMSFLLYANIVYYRFFNDFITIPVI MQAKTNGGQLGDSAFSLMRPTDAFYFIDTIILIILAIKVNKPAETSSKKSFRIIFASS ILVFLINLAVAESDRPELLTRSFDRNYLVKYLGTYNFTIYDAVQNIKSNSQRALADSS DVTEVENYMKANYDVPNNVYFGKAEGKNVIYVSLESLQSFIIDYKIDGKEVTPFLNKL AHDNETFYFDNFFHQTGQGKTSDAEFMMENSLYPLAQGSVFVNKAQNTLQSVPAILKS KNYTSATFHGNTQTFWNRNEMYKAEGIDKFFDSAYYDMNEENTKNYGMKDKPFFKESM PLLESLPQPFYTKFITLSNHFPFGMDEGDTDFPAGDFGDSVVDNYFQSAHYLDQSIEQ FFNDLKKDGLYDKSIIVMYGDHYGISENHNKAMAKVLGKDEITDYDNAQLQRVPLFIH AAGVKGEKVHKYAGDVDVAPTILHLLGVDTKDYLMSGSDILSKEHREVIPFRNGDFIS PKYTKISGKYYDTKTGKELDESEVDKSEDSLVKKELEMSDKIINGDLLRFYEPKGFKK VNPSDYDYTKHDEDSSETSKDNEDK*" gene complement(842047..843996) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" downshifts complement(842064) /Source="Nicolas_upshifts" /id="D384" /incds=0 /nref=219 /ntot=250 /MaxReadThrough="1.71031" /MaxDrop="6.08461" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U589" /TUdmin=0 /isTUend="TRUE" promotor_-35 843106..843112 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 843128..843146 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 843132..844096 /Source="Nicolas_S_feature" /locus_tag="new_843132_844096" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, S8, B60, BC, S7" /AntisenseName="yflE" /AntisenseCor="-0.385555454026206" /AntisenseRegPval="-10.199999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S269" upshifts 843132 /Source="Nicolas_upshifts" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" S_feature complement(843997..844071) /Source="Nicolas_S_feature" /locus_tag="new_843997_844071_c" /HighExp="Paraq, H2O2, LBGexp, G150, G135, G180, Lbexp, C30, LPhT, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S270" promotor_-10 complement(844048..844067) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(844071) /Source="Nicolas_upshifts" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" S_feature complement(844073..844595) /Source="Nicolas_S_feature" /locus_tag="new_844073_844595_c" /HighExp="S3, LoTm, S7, S4, S5, S8, S6, M9-stat, C30, Pyr" /AntisenseName="yflD" /AntisenseCor="0.24383322556613099" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S271" promotor_-35 complement(844083..844087) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 844097..844234 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388653.1" /db_xref="EnsemblGenomes-Gn:BSU07720" /db_xref="EnsemblGenomes-Tr:CAB12601" /db_xref="SubtiList:BG12939" /db_xref="UniProtKB/Swiss-Prot:O34489" /translation="MREKVAKNAVESTFRFDITKCKTRYLSRNKGIKWYIENCMIKYK V*" gene 844097..844234 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" upshifts 844212 /Source="Nicolas_upshifts" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" misc_feature 844213..844232 /Source="Nicolas_upshift_promotors" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 844253..844645 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388655.2" /db_xref="EnsemblGenomes-Gn:BSU07735" /db_xref="EnsemblGenomes-Tr:CAB12603" /db_xref="InterPro:IPR018961" /db_xref="SubtiList:BG12937" /db_xref="UniProtKB/Swiss-Prot:O34887" /translation="MDFSHIVSEDKIKRAIKDGDFQNLPGMGKPLPKDDAAHLPESLR MGYRILKNAGMAEDEGALKKELMTIDHLIEKCYDEKEREQLIRKKSEKQLLLDKLVDK KGMFSKPASAFYKNKVYDRLGRNRPSSS*" gene 844253..844645 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" promotor_-10 complement(844593..844611) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(844608) /Source="Nicolas_upshifts" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" promotor_-35 complement(844627..844632) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 844714..844720 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 844735..844753 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 844735 /Source="Nicolas_upshifts" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" CDS 844770..846185 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid transporter" /protein_id="NP_388656.1" /db_xref="EnsemblGenomes-Gn:BSU07750" /db_xref="EnsemblGenomes-Tr:CAB12604" /db_xref="GOA:O34708" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12936" /db_xref="UniProtKB/Swiss-Prot:O34708" /translation="MERLLVWIEHISDWLWGPPLIILLTGTGLYFTILLKGFQFRYPL YIFKQTIGSVGKKPKGEGTVTPLQALTSALSSTIGAANIVGVPAAIMFGGPGAVFWMW LIALFAMAIKFSESVLAVHYREKNEQGEYVGGPMYYITKGLRMKWLGVFFSVALIVEL IPSIMVQGNSVSVSLAETFSFNKIYAGIGIAFLIGLVVIGGVKRIGKVTEFVVPLMAG AYAGAGLLIVLMNLSSVPAFFSLVFSNAFTSSSAVGGFAGAALAETVRWGFARGLYSN EAGMGTAPIAHAAAMTDHPVRQGFWSVIGIVIDTLIICTTTAFIVLASGVWTGKNASN DPAALTTAAFQHYFGSGGGYFVSVSLVFFVVSTIMVVIFYGVKQAEFLFGRLAGHVIK FVYLAAIIIGAAGGAKAIWGVLDLALVFIVVPNVIALLLLSRKVKALYTEFFTSEQYY LKDIRKTKQKPVYPTKEAKNS*" gene 844770..846185 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" downshifts complement(844771) /Source="Nicolas_upshifts" /id="D385" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="0.76492" /MaxDrop="4.20973" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U593" /TUdmin=22 /isTUend="TRUE" promotor_no_box complement(844797..844897) /Source="Nicolas_upshift_promotors" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(844837) /Source="Nicolas_upshifts" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(846182..847258) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406, 23625846; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane transporter" /protein_id="NP_388657.1" /db_xref="EnsemblGenomes-Gn:BSU07760" /db_xref="EnsemblGenomes-Tr:CAB12605" /db_xref="GOA:O34573" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG12935" /db_xref="UniProtKB/Swiss-Prot:O34573" /translation="MDKTSAYQGLFFGALYTLAVGLKHAPILMIESAKQNAWHSYILG VVIVIPALWLMHRLMKKHQDKNIYELLSDSSPIAGRIIILLFSLYFLLINAHDIRFFI NLINILFLPRTPMAVLGGVIIFVAICIAREGKETLTRMAQIFLFPFGILVLFLPFTLA TQIELQNLTPVFEGLIPYLQSGYYAFGTMGELIILPLLFSNRSVPLKYTIFAILLGAL LLAVMLFSSISVFGPNLTSTFFDPAYMVIRQIRITDFLDRSDLIIAAFWIPVIMVKIA GSLYIVVYGLSFLHSKIDPKAMYTPTGMFSVVCGFWFFLNTNQLIDFNRIKPIINVVI SLLLPLLIYLIIKSKALFGAKAKH*" gene complement(846182..847258) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" S_feature 846186..849552 /Source="Nicolas_S_feature" /locus_tag="new_846186_849552" /HighExp="Salt, Sw, Etha, LoTm, B36, Heat, LPhT, BC, T0.30H, H2O2" /AntisenseName="yfkR" /AntisenseCor="-1.3937740774571999E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.952" /label="S272" CDS complement(847282..847482) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative spore germination D protein" /protein_id="NP_388658.1" /db_xref="EnsemblGenomes-Gn:BSU07770" /db_xref="EnsemblGenomes-Tr:CAB12606" /db_xref="GOA:O35036" /db_xref="SubtiList:BG12934" /db_xref="UniProtKB/Swiss-Prot:O35036" /translation="MISYIVQTLIVCIAIYAYEWKNFRSANNLTKWAFSLLIAGSAFL WIYMRVNPLLPRLGHLFKYIPF*" gene complement(847282..847482) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" CDS complement(847498..848652) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388659.1" /db_xref="EnsemblGenomes-Gn:BSU07780" /db_xref="EnsemblGenomes-Tr:CAB12607" /db_xref="GOA:O35028" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG12933" /db_xref="UniProtKB/Swiss-Prot:O35028" /translation="MKKTIYKCVLPLLICILLTGCWDRTEINDIAFVVSSAIDKKKDQ YRVAMQIPLVGQLGGQTGGGGGTAGSKTWYVDSASGTTIREANNKLQTSLSRTINTSH RRTVIIGEDMARDGVAPVFDILTRNPQNRLTALILVSRGEARDILNTDVQLEQFPAEM IRELAIIATSRPVFLSRFMSDLVEIGSDPYAPVISASKTKPGGKGKSNLKIDGLAIFK KDRLMDIFKDEHMTAALMLLNQARQPEFIVDLPNQMGQASIQLQKSNASFHAAEKNGK LSMTIEIRAKGIIMENQSTYETRENDQYYIIQKALNRTIKKDVISTVHRLQKLKADPA GFQDRTIRSTATTKNLLKKEWEEVYKDMEVHVVPIVTIEQGGVLYKTISH*" gene complement(847498..848652) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" CDS complement(848633..850174) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388660.1" /db_xref="EnsemblGenomes-Gn:BSU07790" /db_xref="EnsemblGenomes-Tr:CAB12608" /db_xref="GOA:O34486" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG12932" /db_xref="UniProtKB/Swiss-Prot:O34486" /translation="MNKRDKALQLIKELEDNQDRPISPNLKENLENLTLLTEGCSDIV FRQFDFGNGLCGFIVYIEGIVKSEHIQDHALRPFLMHLTDQIDEHEEALQNTLSISSV ALETSMSKVAASIIEGNAVLFADGHSKGLILNIKGGQRRSIEEPITESTIRGSREGFT ESLRVNTALVRFRVKTFQLKMISFKIGTKTKTDVVLAYIDGLADPKVIDKAKKRIKKI KIDAVLESGYIEEFIEDDTYSPFPQLQYTERPDTVAAQLLEGRFAIFTDNTPFVLTGP ITFWQLMQASEDYYERYLMSNLIRWLRYMFLFVALYLPAIYVAVITYHQDLMPTNLMF SVASAREPIPFPAIIEALIMEISFEALREAGVRLPKTIGQTVSILGALVIGTAAVEAG IVSAPMVIIVSLTGIASFTIPRFNLAISIRMLRFPLMFLASIFGIFGIMLGTIILVLH LCKLQSFGIPYLSGISPFKRDEVKDIFVRAPWWTMTRRPGTYSRGNGQKGAKREDPKD EENNI*" gene complement(848633..850174) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" promotor_-10 complement(850224..850235) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(850227) /Source="Nicolas_upshifts" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" promotor_-35 complement(850249..850255) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 850284..850291 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 850306..850325 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 850313 /Source="Nicolas_upshifts" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" downshifts complement(850359) /Source="Nicolas_upshifts" /id="D386" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="1.35091" /MaxDrop="3.57201" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U596" /TUdmin=0 /isTUend="TRUE" CDS 850367..851779 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" /EC_number="2.7.1.201" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 8755887, 8917076, 8969503, 18977770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 8755887, 8917076, 8969503, 18977770; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) trehalose-specific enzyme IIBC component" /protein_id="NP_388661.1" /db_xref="EnsemblGenomes-Gn:BSU07800" /db_xref="EnsemblGenomes-Tr:CAB12609" /db_xref="GOA:P39794" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011296" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11009" /db_xref="UniProtKB/Swiss-Prot:P39794" /translation="MGELNKSARQIVEAVGGAENIAAATHCVTRLRFALIDESKVDQE MLDQIDVVKGSFSTNGQFQVVIGQGTVNKVYAELVKETGIGESTKDEVKKASEKNMNP LQRAVKTLADIFIPILPAIVTAGLLMGINNILTAEGIFFSTKSIVQVYPQWADLANMI NLIAGTAFTFLPALIGWSAVKRFGGNPLLGIVLGVMLVHPDLLNAWGYGAAEQSGEIP VWNLFGLEVQKVGYQGQVLPILLASYMLAKIEVFLTKRTPEGIQLLVVAPITLLLTGF ASFIIIGPITFAIGNVLTSGLISVFGSFAALGGLLYGGFYSALVITGMHHTFLAVDLQ LIGSKLGGTFLWPMLALSNIAQGSAALAMMFIVKDEKQKGLSLTSGISAYLGITEPAI FGVNLRYRFPFIIAMVSSGLAGMYISSQGVLASSVGVGGVPGIFSIMSQYWGAFAIGM AIVLIVPFAGTYAYARFKHK*" gene 850367..851779 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" promotor_no_box complement(850385..850485) /Source="Nicolas_upshift_promotors" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(850425) /Source="Nicolas_upshifts" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 851850..853535 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" /EC_number="3.2.1.93" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651129, 7751281, 8755887, 8917076, 9701821, 26894535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651129, 7751281, 8755887, 8917076, 9701821, 26894535; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="trehalose-6-phosphate hydrolase" /protein_id="NP_388662.1" /db_xref="EnsemblGenomes-Gn:BSU07810" /db_xref="EnsemblGenomes-Tr:CAB12610" /db_xref="GOA:P39795" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR012769" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="SubtiList:BG11010" /db_xref="UniProtKB/Swiss-Prot:P39795" /translation="MKTEQTPWWKKAVVYQIYPKSFNDTTGNGVGDLNGIIEKLDYLK TLQVDVLWLTPIYDSPQHDNGYDIRDYYSIYPEYGTMEDFERLVSEAHKRDLKVVMDL VVNHTSTEHKWFREAISSIDSPYRDFYIWKKPQENGSVPTNWESKFGGSAWELDEASG QYYLHLFDVTQADLNWENEEVRKHVYDMMHFWFEKGIDGFRLDVINLISKDQRFPNAE EGDGRSFYTDGPRVHEFLHEMNEKVFSHYDSMTVGEMSSTTVDHCIRYTNPDNKELDM TFSFHHLKVDYPNGEKWALAPFDFLKLKEILSDWQTGMHAGGGWNALFWCNHDQPRVV SRYGDDGAYRVKSAKMLATAIHMMQGTPYIYQGEELGMTNPKFTDISSYRDVESLNMY HAFKEKGMADQDITAILQAKSRDNSRTPVQWDATENGGFTTGTPWIPVAGNYREINAE AALRDQNSVFYHYQKLIQIRKMYDIVTEGTYEIIAKDDPNIFAYLRHGSNEKLLVINN FYGTEAAFTLPDSLAPDEWKAEVLLTNDEAREGLQNMTLRPYESIVYRLTKPC*" gene 851850..853535 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" promotor_-10 complement(852156..852171) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(852163) /Source="Nicolas_upshifts" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(852184..852193) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 853508..853512 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 853528..853547 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 853531 /Source="Nicolas_upshifts" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" CDS 853556..854272 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755887, 9829827, 17705272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755887, 9829827, 17705272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TreR-trehalose)" /protein_id="NP_388663.1" /db_xref="EnsemblGenomes-Gn:BSU07820" /db_xref="EnsemblGenomes-Tr:CAB12611" /db_xref="GOA:P39796" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR012770" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OGG" /db_xref="SubtiList:BG11011" /db_xref="UniProtKB/Swiss-Prot:P39796" /translation="MKVNKFITIYKDIAQQIEGGRWKAEEILPSEHELTAQYGTSRET VRKALHMLAQNGYIQKIRGKGSVVLNREKMQFPVSGLVSFKELAQTLGKETKTTVHKF GLEPPSELIQKQLRANLDDDIWEVIRSRKIDGEHVILDKDYFFRKHVPHLTKEICENS IYEYIEGELGLSISYAQKEIVAEPCTDEDRELLDLRGYDHMVVVRNYVFLEDTSLFQY TESRHRLDKFRFVDFARRGK*" gene 853556..854272 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" downshifts 854265 /Source="Nicolas_upshifts" /id="D387" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="6.58905" /MaxDrop="4.05981" /score="24.6748216" /energy="-11.1" /TU="U595,U598" /idTUdmin="U595" /TUdmin="-792" /isTUend="FALSE" promotor_-35 854347..854350 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 854366..854385 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 854375 /Source="Nicolas_upshifts" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" CDS 854412..855077 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" /EC_number="1.5.1.39" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15252706, 20727918, 20862523, 22238377, 26415543" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 20727918, 20862523, 22238377, 26415543; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H-flavin oxidoreductase (nitroreductase)" /protein_id="NP_388664.1" /db_xref="EnsemblGenomes-Gn:BSU07830" /db_xref="EnsemblGenomes-Tr:CAB12612" /db_xref="GOA:O34475" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="InterPro:IPR033878" /db_xref="SubtiList:BG12931" /db_xref="UniProtKB/Swiss-Prot:O34475" /translation="MADLKTQILDAYNFRHATKEFDPNKKVSDSDFEFILETGRLSPS SLGLEPWKFVVVQNPEFREKLREYTWGAQKQLPTASHFVLILARTAKDIKYNADYIKR HLKEVKQMPQDVYEGYLSKTEEFQKNDLHLLESDRTLFDWASKQTYIALGNMMTAAAQ IGVDSCPIEGFQYDHIHRILEEEGLLENGSFDISVMVAFGYRVRDPRPKTRSAVEDVV KWV*" gene 854412..855077 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" downshifts 855058 /Source="Nicolas_upshifts" /id="D388" /incds=0 /nref=180 /ntot=269 /MaxReadThrough="0.70079" /MaxDrop="6.77615" /score="34.5750428" /energy="-16.9" /TU="NA" /idTUdmin="U595" /TUdmin=1 /isTUend="TRUE" CDS complement(855114..859502) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" /EC_number="3.1.4.16" /EC_number="3.1.3.5" /EC_number="3.1.3.6" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14688230, 16291680, 21800427, 21906378, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported 2',3'-cyclic-nucleotide 2'-phosphodiesterase, 2' (or 3') nucleotidase and 5' nucleotidase" /protein_id="NP_388665.1" /db_xref="EnsemblGenomes-Gn:BSU07840" /db_xref="EnsemblGenomes-Tr:CAB12613" /db_xref="GOA:O34313" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="PDB:3GVE" /db_xref="SubtiList:BG12930" /db_xref="UniProtKB/Swiss-Prot:O34313" /translation="MRIQKRRTHVENILRILLPPIMILSLILPTPPIHAEESAAPQVH LSILATTDIHANMMDYDYYSDKETADFGLARTAQLIQKHREQNPNTLLVDNGDLIQGN PLGEYAVKYQKDDIISGTKTHPIISVMNALKYDAGTLGNHEFNYGLDFLDGTIKGADF PIVNANVKTTSGENRYTPYVINEKTLIDENGNEQKVKVGYIGFVPPQIMTWDKKNLEG QVQVQDIVESANETIPKMKAEGADVIIALAHTGIEKQAQSSGAENAVFDLATKTKGID AIISGHQHGLFPSAEYAGVAQFNVEKGTINGIPVVMPSSWGKYLGVIDLKLEKADGSW KVADSKGSIESIAGNVTSRNETVTNTIQQTHQNTLEYVRKPVGKTEADINSFFAQVKD DPSIQIVTDAQKWYAEKEMKDTEYKNLPILSAGAPFKAGGRNGANYYTNIPAGDLAIK NVGDLYLYDNTVQIVKLTGSEVKDWLEMSAGQFNQIDPAKGGDQALLNENFRSYNFDV IDGVTYQVDVTKPAKYNENGKVINADSSRIINLSYEGKPISPSQEFLVVTNNYRASGG GGFPHLTSDKIVHGSAVENRQVLMDYIIEQKTVNPKADNNWSIAPVSGTNLTFESSLL AKPFADKADDVAYVGKSANEGYGVYKLQFDDDSNPDPPKDGLWDLTVMHTNDTHAHLD DAARRMTKINEVRSETNHNILLDAGDVFSGDLYFTKWNGLADLKMMNMMGYDAMTFGN HEFDKGPTVLSDFLSGNSATVDPANRYHFEAPEFPIVSANVDVSNEPKLKSFVKKPQT FTAGEKKEAGIHPYILLDVDGEKVAVFGLTTEDTATTSSPGKSIVFNDAFETAQNTVK AIQEEEKVNKIIALTHIGHNRDLELAKKVKGIDLIIGGHTHTLVDKMEVVNNEEPTIV AQAKEYGQFLGRVDVAFDEKGVVQTDKSNLSVLPIDEHTEENPEAKQELDQFKNELED VKNEKVGYTDVALDGQREHVRTKETNLGNFIADGMLAKAKEAAGARIAITNGGGIRAG IDKGDITLGEVLNVMPFGNTLYVADLTGKQIKEALEQGLSNVENGGGAFPQVAGIEYT FTLNNKPGHRVLEVKIESPNGDKVAINTDDTYRVATNNFVGAGGDGYSVFTEASHGED LGYVDYEIFTEQLKKLGNKVSPKVEGRIKEVFLPTKQKDGSWTLDEDKFAIYAKNANT PFVYYGIHEGSQEKPINLKVKKDQVKLLKERESDPSLTMFNYWYSMKMPMANLKTADT AIGIKSTGELDVSLSDVYDFTVKQKGKEIKSFKEPVQLSLRMFDIEEAHNPAIYHVDR KKKAFTKTGHGSVDDDMVTGYTNHFSEYTILNSGSNNKPPAFPSDQPTGGDDGNHGGG SDKPGGKQPTDGNGGNDTPPGTQPTNGSGGNGSGGSGTDGPAGGLLPDTATSMYSILL AGFLISALGTAMYLHQRRKQNRANQA*" gene complement(855114..859502) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" downshifts complement(855133) /Source="Nicolas_upshifts" /id="D389" /incds=0 /nref=155 /ntot=229 /MaxReadThrough="1.00159" /MaxDrop="7.08591" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U600" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(859535..859554) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(859552) /Source="Nicolas_upshifts" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" promotor_-35 complement(859569..859572) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 859679..859685 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 859699..859717 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 859702 /Source="Nicolas_upshifts" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" CDS 859745..860263 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="general stress protein 18; deglycase" /protein_id="NP_388666.1" /db_xref="EnsemblGenomes-Gn:BSU07850" /db_xref="EnsemblGenomes-Tr:CAB12614" /db_xref="GOA:P80876" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12929" /db_xref="UniProtKB/Swiss-Prot:P80876" /translation="MGKKIAVVLTYYFEDSEYTEPAKAFKEAGHELTVIEKEKGKTVK GKQGTAEVTVDASIDDVNSSDFDALLIPGGFSPDQLRADDRFVQFTKAFMTDKKPVFA ICHGPQLLINAKALDGRKATGYTSIRVDMENAGADVVDKEVVVCQDQLVTSRTPDDIP AFNRESLALLEK*" gene 859745..860263 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" downshifts 860249 /Source="Nicolas_upshifts" /id="D390" /incds=0 /nref=35 /ntot=153 /MaxReadThrough="8.02255" /MaxDrop="6.97573" /score="42.2080398" /energy="-12.9" /TU="U601" /idTUdmin="U601" /TUdmin="-3542" /isTUend="FALSE" downshifts complement(860293) /Source="Nicolas_upshifts" /id="D391" /incds=0 /nref=22 /ntot=199 /MaxReadThrough="1.59285" /MaxDrop="3.61098" /score="31.1923457" /energy="-11.1" /TU="NA" /idTUdmin="U602" /TUdmin=10 /isTUend="TRUE" S_feature 860294..861944 /Source="Nicolas_S_feature" /locus_tag="new_860294_861944" /HighExp="Etha, S6, S8, S5, S7, Gly, Salt, LoTm, S4, Diami" /AntisenseName="yfkL" /AntisenseCor="-0.52109661167911703" /AntisenseRegPval="-19.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S273" CDS complement(860303..861493) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16828913, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="efflux transporter" /protein_id="NP_388667.1" /db_xref="EnsemblGenomes-Gn:BSU07860" /db_xref="EnsemblGenomes-Tr:CAB12615" /db_xref="GOA:O34597" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12928" /db_xref="UniProtKB/Swiss-Prot:O34597" /translation="MQTTSIKTASGMYINYFFLGMVNIILASNMSSLTKQWNTDPTGI SYVIAAIGFGKLLTYGISGVLSDKIGRKPLVVASAGIMAVFLVGIPLSPSYELAFVFA LLAGVANSAMDAGTYPALTELFPSASGSANVLVKAFMSVGAALLPLLITFLADHSMFY GFAFYLPAAVYLLNIIYLSTLSFPKKHKKPTNSGQQESPVFLSEPVFQKEGTALIIIG FTSTALFTVSQIWLPSYAQKAAGLAESASVQLLSYYSIGSLASVLLLAVLLNRWVKPV FITLLYPIITLCTLAVMLTVHIPVVLDITAFFLGFSTAGVFQITITLMTELFWKRKGT VTGIVATASSLASILLPIATGLIAKAGGIAHIFIFDFGIAVIGTAAAAFLYYRYKKLT GAQA*" gene complement(860303..861493) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" S_feature complement(861494..861585) /Source="Nicolas_S_feature" /locus_tag="new_861494_861585_c" /HighExp="C90, MG 10, BMM, MG-0.2, MG t5, MG 5, MG-0.1, UNK1, HPh, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S274" CDS complement(861586..861801) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388668.1" /db_xref="EnsemblGenomes-Gn:BSU07870" /db_xref="EnsemblGenomes-Tr:CAB12616" /db_xref="InterPro:IPR009507" /db_xref="SubtiList:BG12927" /db_xref="UniProtKB/Swiss-Prot:O35019" /translation="MSSPNTETLTQMIEEISQKLNMLNVGVIKAEDFSDEKIEDLTYL HRMVMKKESFSPSEMQAIAQELASLRK*" gene complement(861586..861801) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" downshifts complement(861645) /Source="Nicolas_upshifts" /id="D392" /incds=0 /nref=1 /ntot=131 /MaxReadThrough="3.65318" /MaxDrop="2.45155" /score="16.183887" /energy="-11.6" /TU="U602" /idTUdmin="U602" /TUdmin="-1342" /isTUend="FALSE" promotor_-10 complement(861833..861852) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(861847) /Source="Nicolas_upshifts" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" promotor_-35 complement(861867..861868) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 861914..861921 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 861936..861955 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 861946 /Source="Nicolas_upshifts" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" CDS 862004..862474 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" /EC_number="3.1.3.48" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-tyrosine-phosphatase" /protein_id="NP_388669.1" /db_xref="EnsemblGenomes-Gn:BSU07880" /db_xref="EnsemblGenomes-Tr:CAB12617" /db_xref="GOA:O35016" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:4ETM" /db_xref="SubtiList:BG12926" /db_xref="UniProtKB/Swiss-Prot:O35016" /translation="MISVLFVCLGNICRSPMAEAIFRDLAAKKGLEGKIKADSAGIGG WHIGNPPHEGTQEILRREGISFDGMLARQVSEQDLDDFDYIIAMDAENIGSLRSMAGF KNTSHIKRLLDYVEDSDLADVPDPYYTGNFEEVCQLIKTGCEQLLASIQKEKQL*" gene 862004..862474 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" CDS 862492..862812 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388670.1" /db_xref="EnsemblGenomes-Gn:BSU07890" /db_xref="EnsemblGenomes-Tr:CAB12618" /db_xref="SubtiList:BG12925" /db_xref="UniProtKB/Swiss-Prot:O34418" /translation="MNNERLMLKGIFLGAAAGAALSLLHKPTRQACGMRWLTCKHKLS LYKSNPELLKNTVITKVDEAKKLARTLSKEVDFVNQQVKELKKTTPQVMELVQETKEH FSKK*" gene 862492..862812 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" CDS 862836..863663 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222749, 12794188, 15849754, 16850406, 15764599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease BN" /protein_id="NP_388671.1" /db_xref="EnsemblGenomes-Gn:BSU07900" /db_xref="EnsemblGenomes-Tr:CAB12619" /db_xref="GOA:O34437" /db_xref="InterPro:IPR017039" /db_xref="SubtiList:BG12924" /db_xref="UniProtKB/Swiss-Prot:O34437" /translation="MSFLKELFSRYTLHEGQSKSAELAYFFLLSLFPFLIFMLTLTAY LPLSTDDVLGVIEQYAPASAMSLVESITHQTLNNRNGGLLSFGIIAALWSASNGMNAI VRSLNHAYDVEENRSFIIVRLTSIFLTIAMVFTILVALLLPVFGREIGRLASDFVGAS DLFLSVWAAIRWGVSPLVLLIVFSALYVIAPNKKLSLRFVMPGAVFATIGWIIVSTLF SFYVSTFANYSATYGSIGGIIVLMIWFYLSGILIILGGEINALLHKRKKLPDENPYH* " gene 862836..863663 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" promotor_-35 863642..863648 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 863663..863674 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 863681..863837 /Source="Nicolas_S_feature" /locus_tag="new_863681_863837" /HighExp="S8, Etha, S6, Salt, S7, S5, ferm, nit, BT, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99976299999999996" /TUshortSig="SigGF, SigA, SigB" /TUshortPSig="0.974, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S275" upshifts 863681 /Source="Nicolas_upshifts" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" downshifts complement(863713) /Source="Nicolas_upshifts" /id="D393" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.22239" /MaxDrop="3.61507" /score="-5.45682213" /energy="-3" /TU="NA" /idTUdmin="U606" /TUdmin=440 /isTUend="FALSE" downshifts 863812 /Source="Nicolas_upshifts" /id="D394" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="1.4253" /MaxDrop="6.85849" /score="25.8200126" /energy="-17.9" /TU="NA" /idTUdmin="U603" /TUdmin="-1" /isTUend="TRUE" CDS complement(863862..865037) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388672.1" /db_xref="EnsemblGenomes-Gn:BSU07910" /db_xref="EnsemblGenomes-Tr:CAB12620" /db_xref="GOA:O34929" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12923" /db_xref="UniProtKB/Swiss-Prot:O34929" /translation="MSRFHFFILVLLVSISGFSQGMLLPVISIIFETNGESAAINGLH ATGLYIGVLLASPFMEAPLRKLGFKPLIVMGGSIVILSLFGFIWLQSVWVWFLLRLFI GIGDHMLHFSTQTWVTSMSSKQNRGRNLSIYGLSFGLGFAAGPFMVPLVKLSPSLPFI VSGCISLFAWLFVFFLQNAYPETSPHETKSDNSFRRFYQAMLFGWVAFMPTFGYGFLE TALNGSFPVYALRLGISVDAVAIILPAFAIGSIIFQFPLGILSDKYGRRNVLLVILLT GALCFFIAGVFPSPYVIGGCFFIAGMAVGSTFTLGISYMTDLLPPHLLPAGNLLCGIT FSLGSILGPVAGGWYMQTFESANLFYFITLTLSSVWLALVLGKPKSWSPAETYSSSS* " gene complement(863862..865037) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" downshifts complement(863867) /Source="Nicolas_upshifts" /id="D395" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="0.37084" /MaxDrop="3.28031" /score="3.2266059" /energy="-14.1" /TU="NA" /idTUdmin="U606" /TUdmin=286 /isTUend="FALSE" promotor_-35 864474..864480 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 864496..864514 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 864500..865153 /Source="Nicolas_S_feature" /locus_tag="new_864500_865153" /HighExp="Etha, M9-stat, Salt, Sw, Gly, B60, Heat, LPhT, HiTm, T0.30H" /AntisenseName="yfkF" /AntisenseCor="-0.18505347560608301" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S276" upshifts 864500 /Source="Nicolas_upshifts" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" promotor_-10 complement(865062..865081) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(865077) /Source="Nicolas_upshifts" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" promotor_-35 complement(865095..865102) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 865143..865148 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 865155 /Source="Nicolas_upshifts" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" promotor_-10 865163..865181 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 865205..866260 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19543710, 23798403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19543710, 23798403; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+/Ca2+ antiporter" /protein_id="NP_388673.1" /db_xref="EnsemblGenomes-Gn:BSU07920" /db_xref="EnsemblGenomes-Tr:CAB12621" /db_xref="GOA:O34840" /db_xref="InterPro:IPR004713" /db_xref="InterPro:IPR004798" /db_xref="InterPro:IPR004837" /db_xref="PDB:4KJR" /db_xref="PDB:4KJS" /db_xref="SubtiList:BG12922" /db_xref="UniProtKB/Swiss-Prot:O34840" /translation="MNRIFFILVAAGVPLSVIGSLMHWPSAVLFAVYCVTIIALASYM GRATESLSIIAGPRIGGLLNATFGNAVELIISLFALKEGLTGIVLASLTGSVLGNLLL VAGLSFFVGGLKYKRQEFNIHDARHNSGLLIFAIIVAFVIPEVFSVGMGNASKLNLSI GISIIMILLYVAALYFKLVTHRGVYQPNNAAQTEEEEEPEWSGKVATIVLFAATIVVA YISENLVHTFHSVAEQFGWSELFIGVIIVAIVGNAAEHASAIIMAFKNKMDIAVEIAV GSTLQIAMFVAPVLVICSIFFPTSMPLVFTLPELVAMVSAVLLMIAISNDGDSNWFEG ATLLAAYVIMAIGFFLL*" gene 865205..866260 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" promotor_-35 866274..866280 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 866295..866306 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 866299 /Source="Nicolas_upshifts" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" CDS 866331..867125 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19543710" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388674.1" /db_xref="EnsemblGenomes-Gn:BSU07930" /db_xref="EnsemblGenomes-Tr:CAB12622" /db_xref="InterPro:IPR025548" /db_xref="SubtiList:BG12921" /db_xref="UniProtKB/Swiss-Prot:O34579" /translation="MMKKLFHSTLIVLLFFSFFGVQPIHAKKQFKVPNSVASISKENT YPNASQDQPMLQPSKLAKELLDHSEVKIENPHLIKMLNESNISGTPLAVGYRATIFLG KWALGYESNETVANWEYKKINTNRADNRGGKETAEMHYAQEQQYRVKGGLTAKVPNAE DVKSMMMQKAMKKTNLPLAFETVIGAGTKRDQIYKVAPKKIGYLHAYAPAVNEKGKVT YGEVYLVLKGNKRKLVVKNVTSQGIGAWIPVQDHVTFGFQLSSLPR*" gene 866331..867125 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" downshifts 867113 /Source="Nicolas_upshifts" /id="D396" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="0.82657" /MaxDrop="5.7252" /score="28.7014976" /energy="-9.5" /TU="NA" /idTUdmin="U605" /TUdmin=0 /isTUend="TRUE" CDS complement(867164..868006) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17665170, 18310427, 19252899; Product type t: transporter" /codon_start=1 /transl_table=11 /product="mechanosensitive ion channel" /protein_id="NP_388675.1" /db_xref="EnsemblGenomes-Gn:BSU07940" /db_xref="EnsemblGenomes-Tr:CAB12623" /db_xref="GOA:O35043" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="SubtiList:BG12920" /db_xref="UniProtKB/Swiss-Prot:O35043" /translation="MRMKETLTEIFQNKIVDILLVAVILWIGVFIINRLVQLFFKRTD FIEEKKEKTIESLVRSVTQYTATIGFIFYVISLFVHDFGKILAGAGVAGIVIGFGAQS LIKDVLAGVFLIYERQLHKGDYVTVNNLFNGTVEEIGLRSLQIREWSGKLLTISNGEV RQIENYNIDFMRITESFLISFKEDPDRVYSVLEEACDMLNEELRDSLKRDEFGNPTEP FQIHGITALNKINRGVEFTVKGMVKDDDYFSASLAVRRVLVRQLYQNNVQMLEEAVRI ERTQ*" gene complement(867164..868006) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" downshifts complement(867166) /Source="Nicolas_upshifts" /id="D397" /incds=0 /nref=58 /ntot=230 /MaxReadThrough="1.96922" /MaxDrop="4.8789" /score="23.5281308" /energy="-9.8" /TU="NA" /idTUdmin="U609" /TUdmin=1 /isTUend="TRUE" CDS complement(868007..869128) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative Fe-S oxidoreductase, radical SAM superfamily" /protein_id="NP_388677.2" /db_xref="EnsemblGenomes-Gn:BSU07955" /db_xref="EnsemblGenomes-Tr:CAB12625" /db_xref="GOA:O34400" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014866" /db_xref="InterPro:IPR031004" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG12918" /db_xref="UniProtKB/Swiss-Prot:O34400" /translation="MTQNTKLRPITPEFDPWEAYMDVDQYGDMQLTNVEFTTTTLCNM RCEHCAVGYTLQPKDPNALPIDLLLKRLEEIPRLRSISITGGEPMLSLKSVKEYVVPL LKYAHERGVRTQINSNLTLDIERYEWIIPYLDVLHISHNWGTVEDFAEIGFAMMDRKP TFEQRARYFEKMIENSRTLVDAGVMVSAETMLNKRTLPHIEHIHRQITEDMKCQRHEV HPMYPSDFASALESLSLKEMRQAIHRLLDIRDENTWMLFGTLPFYACSPDEDDQKLLR RLRAAKNVTVRNDPDGRSRLNVNIFDGNIIVTDFGDTPPLGNIQTDSLPSAYEKWRET KLAKELSCHCPNVRCLGPNVLVKNSYYQDTDFTKRQARS*" gene complement(868007..869128) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" promotor_-10 complement(869169..869188) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(869187) /Source="Nicolas_upshifts" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" promotor_-35 complement(869204..869208) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 869216..869223 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 869237..869256 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 869247 /Source="Nicolas_upshifts" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" CDS 869273..869458 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388678.1" /db_xref="EnsemblGenomes-Gn:BSU07970" /db_xref="EnsemblGenomes-Tr:CAB12626" /db_xref="SubtiList:BG12916" /db_xref="UniProtKB/Swiss-Prot:O35041" /translation="MGNAVNNKDQQIDYLKNRLDMFMNVIDSLDPEATDVEDIDRLIS MLDDLEAKYERFKKDWE*" gene 869273..869458 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" downshifts 869437 /Source="Nicolas_upshifts" /id="D398" /incds=0 /nref=15 /ntot=177 /MaxReadThrough="3.03457" /MaxDrop="3.24661" /score="14.1645187" /energy="-6.4" /TU="U610" /idTUdmin="U610" /TUdmin="-559" /isTUend="FALSE" promotor_-35 869501..869507 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 869513 /Source="Nicolas_upshifts" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" promotor_-10 869522..869533 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 869559..870350 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 15687192" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 15687192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported peptidoglycan N-acetylmuramic acid deacetylase" /protein_id="NP_388679.1" /db_xref="EnsemblGenomes-Gn:BSU07980" /db_xref="EnsemblGenomes-Tr:CAB12627" /db_xref="GOA:O34928" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014235" /db_xref="PDB:1NY1" /db_xref="PDB:1W17" /db_xref="PDB:1W1A" /db_xref="PDB:1W1B" /db_xref="SubtiList:BG12915" /db_xref="UniProtKB/Swiss-Prot:O34928" /translation="MKWMCSICCAAVLLAGGAAQAEAVPNEPINWGFKRSVNHQPPDA GKQLNSLIEKYDAFYLGNTKEKTIYLTFDNGYENGYTPKVLDVLKKHRVTGTFFVTGH FVKDQPQLIKRMSDEGHIIGNHSFHHPDLTTKTADQIQDELDSVNEEVYKITGKQDNL YLRPPRGVFSEYVLKETKRLGYQTVFWSVAFVDWKINNQKGKKYAYDHMIKQAHPGAI YLLHTVSRDNAEALDDAITDLKKQGYTFKSIDDLMFEKEMRLPSL*" gene 869559..870350 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" downshifts 870348 /Source="Nicolas_upshifts" /id="D399" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.12067" /MaxDrop="3.4013" /score="14.4741934" /energy="-10.2" /TU="NA" /idTUdmin="U611" /TUdmin=22 /isTUend="TRUE" CDS complement(870388..871248) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative beta-hydroxyacid dehydrogenase" /protein_id="NP_388680.2" /db_xref="EnsemblGenomes-Gn:BSU07990" /db_xref="EnsemblGenomes-Tr:CAB12628" /db_xref="GOA:O34969" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12914" /db_xref="UniProtKB/Swiss-Prot:O34969" /translation="MKIAVIGLGNMGQPIARNVLQAGYELTVYNRTKQKTEDLVTEGA QAADTPRLAAKSADIVITMLADDDSVSTVTFGEDGLLEGLAENGIHISMSTISVEFSE KLAAAHAEKGQFFLAAPVLGRPDAAAKAALRIITAGPAEAKQAAKPLLDSLSQQIFDV GEESKTANAAKISINFLLVSMLEALSESFLMMEKYGLEQKQFLEIASALFGSPVYQNY GTIMAEQKFEPAGFKMSLGLKDTNLALAAAKRVSANLPLAELAKSHFESGIEKGFGDL DWAALIKCIK*" gene complement(870388..871248) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" downshifts complement(870402) /Source="Nicolas_upshifts" /id="D400" /incds=0 /nref=15 /ntot=193 /MaxReadThrough="2.61589" /MaxDrop="3.98341" /score="-1.3382901" /energy="-12.1" /TU="NA" /idTUdmin="U612" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(871268..871287) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(871282) /Source="Nicolas_upshifts" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" promotor_-35 complement(871303..871306) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(871347..872306) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563871, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="divalent cation (octahedral coordination) transporter" /protein_id="NP_388681.1" /db_xref="EnsemblGenomes-Gn:BSU08000" /db_xref="EnsemblGenomes-Tr:CAB12629" /db_xref="GOA:O31543" /db_xref="InterPro:IPR002523" /db_xref="InterPro:IPR004488" /db_xref="SubtiList:BG12913" /db_xref="UniProtKB/Swiss-Prot:O31543" /translation="MINITAITTEHQLLKNIPIERVEQPDIAWYWVDFYGPEDTETAL LRDFFHFHPLAIEDCFQHMQRPKLDHYDGYRFYVIHALNKETLETEEVDIFQGEKFVV TFHLHETPGIAKVRERLYASPDILKKGPGHISYMIMDQLVDEYFPLVYKIEDRLNEIE ESRPHKTYGTLMNEVFDLRTDLLHLRRTIIPMRDLLYRILSLDHVKEQRETKAYFSDI YDHLLKLSEIVESNRDMTSDLRDSYVTLNSNRMNAIMMTLTIVSTIFIPLTFIAGVYG MNFDFMPELHWKYGYFAVLGLMAALVIGMLIWFVHKGWFNIFK*" gene complement(871347..872306) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" downshifts complement(871370) /Source="Nicolas_upshifts" /id="D401" /incds=0 /nref=137 /ntot=224 /MaxReadThrough="2.29296" /MaxDrop="4.2496" /score="10.2736001" /energy="-7.5" /TU="NA" /idTUdmin="U613" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(872317..872336) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(872320) /Source="Nicolas_upshifts" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" promotor_-35 complement(872352..872355) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 872367..872371 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 872385..872404 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 872394 /Source="Nicolas_upshifts" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" CDS 872425..873288 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" /EC_number="3.2.2.21" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA-3-methyladenine glycosylase" /protein_id="NP_388682.1" /db_xref="EnsemblGenomes-Gn:BSU08010" /db_xref="EnsemblGenomes-Tr:CAB12630" /db_xref="GOA:O31544" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG12912" /db_xref="UniProtKB/Swiss-Prot:O31544" /translation="MWKEKVSVTPPYHFDRVLDRLSLDPLNAVDREAREVRVPIRNQA GDVCIVKVQALGHAGEPEFLVSGETDQGEMMKEIKRIFQWENHLQHVLDHFSKTSLSA IFEEHAGTPLVLDYSVYNCMMKCIIHQQLNLSFAYTLTERFVHAFGEQKDGVWCYPKP ETIAELDYQDLRDLQFSMRKAEYTIDTSRMIAEGTLSLSELPHMADEDIMKKLIKIRG IGPWTVQNVLMFGLGRPNLFPLADIGLQNAIKRHFQLDDKPAKDVMLAMSKEWEPYLS YASLYLWRSIE*" gene 872425..873288 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" S_feature 873289..873401 /Source="Nicolas_S_feature" /locus_tag="new_873289_873401" /HighExp="BC, M40t90, LBGtran, C90, M9-stat, M0t90, Lbtran, Sw, M40t45, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S277" CDS 873402..874802 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methyltransferase" /protein_id="NP_388683.1" /db_xref="EnsemblGenomes-Gn:BSU08020" /db_xref="EnsemblGenomes-Tr:CAB12631" /db_xref="GOA:O31545" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12911" /db_xref="UniProtKB/Swiss-Prot:O31545" /translation="MNQQKKQAPVELKVGQTFPLTIKRLGINGEGVGYFKKKVVFVPG ALPGEEVVVQATKVQPKFSEGRIKKIRKASEHRVAPPCPVYEQCGGCQLQHLAYSQQL REKRDIVIQSLERHTKFKVENMEIKETIGMDNPWNYRNKSQFQIGRSQSGSIIAGLYG LDSHDIVPIKDCIVQHPATNKTTGIVRRILEDFNVSVYNERKRKGDVRTIVTRVGFET GEVQVVLVTAKETLPHKEEIVKAIQKRLPEVKSIIQNVNGAKTSVIFGEKTKQLAGKT VIQEVLGDVSFELSARAFFQLNPEQTVKLYDEVKKAAQLTGKEKVVDAYCGVGTIGMW VADGAKEVRGMDVIKESIDDAKKNAKKHGMANATYVTGTAEHWLPKWTKEGFRPDVVI VDPPRTGCDSTFLDTIKKVKPKRFVYVSCNPSTLAKDLQTLSKDYRVDYIQPVDMFPQ TAHVEAVARLVLKSSN*" gene 873402..874802 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" downshifts 874814 /Source="Nicolas_upshifts" /id="D402" /incds=0 /nref=198 /ntot=251 /MaxReadThrough="1.18186" /MaxDrop="5.19313" /score="11.8630961" /energy="-12.6" /TU="NA" /idTUdmin="U614" /TUdmin=0 /isTUend="TRUE" promotor_-35 875108..875115 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 875131..875150 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 875137 /Source="Nicolas_upshifts" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" S_feature 875144..875427 /Source="Nicolas_S_feature" /locus_tag="new_875144_875427" /HighExp="M9-stat, T1.30H, T0.30H, T2.0H, LoTm, T3.0H, T3.30H, T1.0H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69102300000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S278" CDS 875428..875694 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097694.1" /db_xref="EnsemblGenomes-Gn:BSU08029" /db_xref="EnsemblGenomes-Tr:CAX52581" /db_xref="GOA:C0H3X6" /db_xref="InterPro:IPR025627" /db_xref="UniProtKB/Swiss-Prot:C0H3X6" /translation="MDKVYKRSWFQTFLAFLVSQLYFNFVELTGWGPKYREMNGFPAN IVELDFFQTYLSFYDNPWFNIITVFLGVFTIIQIITGITKDIRN*" gene 875428..875694 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" promotor_-10 complement(875642..875661) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(875660) /Source="Nicolas_upshifts" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(875676..875679) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 875695..876176 /Source="Nicolas_S_feature" /locus_tag="new_875695_876176" /HighExp="G180, Paraq, H2O2, G135, Oxctl, G150, C30, LoTm, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S279" promotor_-35 876147..876150 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 876167..876186 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 876178..876425 /Source="Nicolas_S_feature" /locus_tag="new_876178_876425" /HighExp="H2O2, G180, Paraq, G150, G135, Oxctl, dia15, LBGstat, LBGexp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S280" upshifts 876178 /Source="Nicolas_upshifts" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" CDS 876426..877403 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" /EC_number="1.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 25902496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase 2" /protein_id="NP_388684.1" /db_xref="EnsemblGenomes-Gn:BSU08030" /db_xref="EnsemblGenomes-Tr:CAB12632" /db_xref="GOA:O31546" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG12910" /db_xref="UniProtKB/Swiss-Prot:O31546" /translation="MTENFWRELPRPFFVLAPMEDVTDVVFRHVVSEAGRPDVFFTEF TNSESYCHPDGKDSVRGRLTFTEDEQPIVAHIWGDKPENFRKMSIGMAELGFKGLDIN MGCPVPNVAGNGKGSGLICRPAVAAELIQAAKAGGLPVSVKTRLGYTDVDEWREWLTH ILKQDIANLSIHLRTRAEMSKVDAHWELIPEIKKLRDEVAPDTLLTINGDIPDRQTGL KLAEQYGVDGIMIGRGIFTNPFAFEKEPKEHSSKELLDLLRLHLDLHDEYSKEEARPY KPLPRFFKIYLRGFRGASELRNQCMNTKSTDEVRALLDDFERKYLDGIE*" gene 876426..877403 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" S_feature 877404..877496 /Source="Nicolas_S_feature" /locus_tag="new_877404_877496" /HighExp="G135, G180, Paraq, G150, H2O2, LBGexp, aero, dia0, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S281" downshifts 877453 /Source="Nicolas_upshifts" /id="D403" /incds=0 /nref=86 /ntot=218 /MaxReadThrough="3.30163" /MaxDrop="4.0519" /score="11.8630961" /energy="-12.6" /TU="U617" /idTUdmin="U618" /TUdmin="-1211" /isTUend="FALSE" promotor_-35 877537..877543 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 877555..877574 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 877564 /Source="Nicolas_upshifts" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" CDS 877599..878051 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388685.1" /db_xref="EnsemblGenomes-Gn:BSU08040" /db_xref="EnsemblGenomes-Tr:CAB12633" /db_xref="SubtiList:BG12909" /db_xref="UniProtKB/Swiss-Prot:O31547" /translation="MKRLCIIPCGKKKIWDVQPDAGPVRAEDAYLSPFHQACERYAKT FFDEWVILSAKHGFLRPDDLVSGNYDVTFGTGHPEIMTADELRRQFHEKGFSDIEELV MLGGKKYRSVLNAVIGEHQHISWPLSSYKGIGYMLQALNRAVEEKHEL*" gene 877599..878051 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" CDS 878081..878770 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388686.1" /db_xref="EnsemblGenomes-Gn:BSU08050" /db_xref="EnsemblGenomes-Tr:CAB12634" /db_xref="InterPro:IPR020523" /db_xref="SubtiList:BG11034" /db_xref="UniProtKB/Swiss-Prot:P40773" /translation="MKKLVFGLLAIVLFGCGLYIYHVWFGDPFSKNAAEQKLVSYVKQ TYPKKEIKITNGVYNAKTSEYVFEATSQSHRYPMCTKGFLHPKVTCDGIEEAYTESVA KHVNEEATKAIEADLKKAVPRFIKADAALSIENGQFTLDTKWNKKLAEKAPMSMTIQL DASGLSKTDAAKMAETVRKTLNEKGYTYSNGTIDCMQKDGDGGIGYVKYSIDFLSKAA IQSNDAEELGS*" gene 878081..878770 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" downshifts 878775 /Source="Nicolas_upshifts" /id="D404" /incds=0 /nref=31 /ntot=205 /MaxReadThrough="0.02745" /MaxDrop="3.61164" /score="23.9796437" /energy="-9" /TU="NA" /idTUdmin="U617" /TUdmin=1 /isTUend="TRUE" misc_feature 878947..878965 /Source="Nicolas_upshift_promotors" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 878954 /Source="Nicolas_upshifts" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" CDS 879002..880003 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109, 22714279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109, 22714279; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent alpha subunit)" /protein_id="NP_388687.1" /db_xref="EnsemblGenomes-Gn:BSU08060" /db_xref="EnsemblGenomes-Tr:CAB12635" /db_xref="GOA:O31404" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12558" /db_xref="UniProtKB/Swiss-Prot:O31404" /translation="MKLLKREGLSLTEEKALWMYQKMLEIRGFEDKVHELFAQGVLPG FVHLYAGEEAVAVGVCAHLHDGDSITSTHRGHGHCIAKGCDLDGMMAEIFGKATGLCK GKGGSMHIADLDKGMLGANGIVGGGFTLACGSALTAKYKQTKNVSVCFFGDGANNQGT FHEGLNLAAVWNLPVVFVAENNGYGEATPFEYASACDSIADRAAAYNMPGVTVDGKDI LAVYQAAEEAIERARNGGGPSLIECMTYRNYGHFEGDAQTYKTKDERVEHLEEKDAIQ GFKNYLLKETDANKLSDIEQRVSESIEKAVSFSEDSPYPKDSELLTDVYVSYEKGGM* " gene 879002..880003 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" CDS 880007..881035 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 10368162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 10368162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent beta subunit)" /protein_id="NP_388688.1" /db_xref="EnsemblGenomes-Gn:BSU08070" /db_xref="EnsemblGenomes-Tr:CAB12636" /db_xref="GOA:O34591" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG12559" /db_xref="UniProtKB/Swiss-Prot:O34591" /translation="MARVISMSDAINEAMKLAMRKDENVLLIGEDVAGGAAVDHLQDD EAWGGVLGVTKGLVQEFGRTRVLDTPISEAGYMGAAMAAASTGLRPIAELMFNDFIGT CFDQVINQGAKFRYMFGGKAQVPITVRTTYGAGFRAAAQHSQSLYGLFTSIPGLKTVV PSNPYDAKGLLLAAIEDNDPVFFFEDKTSYNMKGEVPEDYYTIPLGKADIKREGNDVT LFAVGKQVNTALEAAAQLSERGIEAEVLDPRSLSPLDEDAIFTSLEKTNRLIIIDEAN PRCSIATDIAALVADKGFDLLDAPIKRITAPHTPVPFSPVLEDQYLPTPDKIVSVTLE LLGEPALN*" gene 880007..881035 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" CDS 881049..882245 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" /EC_number="2.3.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E2 component (dihydrolipoamide acetyltransferase)" /protein_id="NP_388689.1" /db_xref="EnsemblGenomes-Gn:BSU08080" /db_xref="EnsemblGenomes-Tr:CAB12637" /db_xref="GOA:O31550" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG12560" /db_xref="UniProtKB/Swiss-Prot:O31550" /translation="MAVKVVMPKLGMAMKQGEVSIWNKKVGDPVEKGESIASIQSEKI EMEIEAPEKGTLIDIKVKEGEEVPPGTAICYIGDANESVQEEAGAPVAEDNMPQAVQP VKQENKPAASKKDRMKISPVARKIAEKAGLDLKQLKGTGPGGRIVKDDVTKALAEQKK DQAKPVSEQKAQEIPVTGMRKVIAARMQESLANSAQLTITMKADITKLATLQKQLSPT AEERYGTKLTITHFVSRAAVLALQAHPVLNSFYQNERIITHPHVHLGMAVALENGLVV PVIRHAEKLSLIELAQSISENAKKAREGRAGSEELQGSTFSITNLGAFGVEHFTPILN PPETGILGIGASYDTPVYQGEEIVRSTILPLSLTFDHRACDGAPAAAFLKAMKTYLEE PAALIL*" gene 881049..882245 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" downshifts complement(881050) /Source="Nicolas_upshifts" /id="D405" /incds=0 /nref=8 /ntot=46 /MaxReadThrough="0.481579999999999" /MaxDrop="4.16582" /score="-0.0231058321" /energy="-9.9" /TU="NA" /idTUdmin="U623" /TUdmin=4796 /isTUend="FALSE" CDS 882266..883642 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" /EC_number="1.8.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E3 component (dihydrolipoamide dehydrogenase)" /protein_id="NP_388690.1" /db_xref="EnsemblGenomes-Gn:BSU08090" /db_xref="EnsemblGenomes-Tr:CAB12638" /db_xref="GOA:O34324" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12561" /db_xref="UniProtKB/Swiss-Prot:O34324" /translation="MTLAIIGGGPAGYAAAVSAAQQGRNVLLIDKGKLGGTCLNEGCI PTKSLLESANVLDKIKHADSFGIELPAGAISVDWSKMQSRKQQVVSQLVQGVQYLMKK NQIQVVKGTASFLSERKLLIEGENGKEIREADQVLIASGSEPIELPFAPFDGEWILDS KDALSLSEIPSSLVIVGGGVIGCEYAGLFARLGSQVTIIETADRLIPAEDEDIARLFQ EKLEEDGVEVHTSSRLGRVDQTAKTAIWKSGQREFKTKADYVLVAIGRKPRLDGLQLE QAGVDFSPKGIPVNGHMQTNVPHIYACGDAIGGIQLAHAAFHEGIIAASHASGRDVKI NEKHVPRCIYTSPEIACIGMTERQARSIYGDVKIGEFSFSANGKALIKQQAEGKVKIM AEPEFGEIVGVSMIGPDVTELIGQAAAIMNGEMTADMAEHFIAAHPTLSETLHEALLS TIGLAVHA*" gene 882266..883642 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" downshifts 883636 /Source="Nicolas_upshifts" /id="D406" /incds=0 /nref=27 /ntot=56 /MaxReadThrough="5.75671" /MaxDrop="5.6153" /score="27.0133719" /energy="-14.7" /TU="U619" /idTUdmin="U619" /TUdmin="-2156" /isTUend="FALSE" promotor_-35 883689..883696 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 883709..883728 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 883717 /Source="Nicolas_upshifts" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" CDS 883758..885575 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" /experiment="publication(s) with functional evidences, PMID:11274109, 16944132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 16944132; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AcoR-acetoin)" /protein_id="NP_388691.1" /db_xref="EnsemblGenomes-Gn:BSU08100" /db_xref="EnsemblGenomes-Tr:CAB12639" /db_xref="GOA:O31551" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG11790" /db_xref="UniProtKB/Swiss-Prot:O31551" /translation="MNSVPNDLQTWKRFVKDGVLDEARLRKRIAESWHRCKKAEVNPY LEKGPKVLQQTELDQQSKKHSFFLTTAKPYLEKLLPAIKEMEMMALLIDSDGVVLALD GHPRALYEAKRINFVEGACWTETAVGTNAIGTALHISEPVAIQGSEHYSIASHLWNCS AAPIHHEDGSLAGVIDISCPAAGAHPHMLGIATAIAYAAERELAAKSREKELELISRF GERAASSVPMVLCNTKQHIISASMPIRTSMPDWQGRHLYELKERGYSIENAVTIGDGG TCFYLSEQKKKKAFRFNGVIGQSGRSQAMLMHLERAAATDASVCLSGETGTGKEVAAR ALHENSERRHGPFVAVNCGAIPSDLIESELFGYAEGAFTGAKRNGYKGAFQKANQGTL FLDEIGEISHSMQVALLRVLQERKITPIGGTKEIPVDIRVIAATHCDLRELAENGKIR EDLFYRLHVYPIELPPLRDRTEDIPDLFEYYKQKNHWPGDLPSDFCNVLKQWKWPGNI RELFNVFERLSIRFPDGRLRDESLPALLEAAGLPASSAEKKPAAAGVLTFREQIQKDM MIKALESAKGNVSQAAKISGIPRSTFYKRLKKFNLSAES*" gene 883758..885575 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" promotor_-35 885576..885582 /Source="Nicolas_upshift_promotors" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 885594 /Source="Nicolas_upshifts" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" promotor_-10 885597..885608 /Source="Nicolas_upshift_promotors" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 885629..885808 /gene="sspH" /locus_tag="BSU_08110" /old_locus_tag="BSU08110" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_388692.1" /db_xref="EnsemblGenomes-Gn:BSU08110" /db_xref="EnsemblGenomes-Tr:CAB12640" /db_xref="GOA:O31552" /db_xref="InterPro:IPR012610" /db_xref="SubtiList:BG12917" /db_xref="UniProtKB/Swiss-Prot:O31552" /translation="MNIQRAKEIVESPDMKKVTYNGVPIYIQHVNEETGTARIYPLDE PQEEHEVQLNSLKED*" gene 885629..885808 /gene="sspH" /locus_tag="BSU_08110" /old_locus_tag="BSU08110" downshifts 885792 /Source="Nicolas_upshifts" /id="D407" /incds=0 /nref=96 /ntot=181 /MaxReadThrough="1.9176" /MaxDrop="6.06509" /score="5.08326573" /energy="-12" /TU="NA" /idTUdmin="U619" /TUdmin=0 /isTUend="TRUE" CDS complement(885844..886173) /gene="yfjF" /locus_tag="BSU_08120" /old_locus_tag="BSU08120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388693.1" /db_xref="EnsemblGenomes-Gn:BSU08120" /db_xref="EnsemblGenomes-Tr:CAB12641" /db_xref="GOA:O31553" /db_xref="InterPro:IPR003844" /db_xref="SubtiList:BG12908" /db_xref="UniProtKB/Swiss-Prot:O31553" /translation="MMLITILLFLAAGLAEIGGGYLVWLWLREAKPAGYGIAGALILI VYGILPTFQSFPSFGRVYAAYGGVFIVLAVLWGWLVDRKTPDLYDWIGAFICLIGVCV ILFAPRG*" gene complement(885844..886173) /gene="yfjF" /locus_tag="BSU_08120" /old_locus_tag="BSU08120" downshifts complement(885858) /Source="Nicolas_upshifts" /id="D408" /incds=0 /nref=96 /ntot=245 /MaxReadThrough="2.05328" /MaxDrop="6.2642" /score="34.1179702" /energy="-15.8" /TU="NA" /idTUdmin="U623" /TUdmin="-12" /isTUend="TRUE" CDS complement(886223..886681) /gene="yfjE" /locus_tag="BSU_08130" /old_locus_tag="BSU08130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388694.1" /db_xref="EnsemblGenomes-Gn:BSU08130" /db_xref="EnsemblGenomes-Tr:CAB12642" /db_xref="GOA:O31554" /db_xref="InterPro:IPR035324" /db_xref="SubtiList:BG12907" /db_xref="UniProtKB/Swiss-Prot:O31554" /translation="MSEALTFESKYALLYLGGGLLAMIYGLITFFMAFPAFTSRGNVI FTIKTGPSGEIFLRKRSVLFSEVKRLYMGRHQYSLKGIFFEDIIIEKTDGKIVRIPTW NIITNPLFFEAVERYILPHLNEEAQNNWISQFTEVQRKAYLKEFENHPKL*" gene complement(886223..886681) /gene="yfjE" /locus_tag="BSU_08130" /old_locus_tag="BSU08130" S_feature complement(886682..886774) /Source="Nicolas_S_feature" /locus_tag="new_886682_886774_c" /HighExp="BI, BC, S2, Sw, HiOs, HiTm, S5, ferm, S4, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S282" CDS complement(886775..887332) /gene="yfjD" /locus_tag="BSU_08140" /old_locus_tag="BSU08140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388695.1" /db_xref="EnsemblGenomes-Gn:BSU08140" /db_xref="EnsemblGenomes-Tr:CAB12643" /db_xref="GOA:O31555" /db_xref="InterPro:IPR035324" /db_xref="SubtiList:BG12906" /db_xref="UniProtKB/Swiss-Prot:O31555" /translation="MKNQEIIEVKSKMFLRIWAFVGSAGMGLACLWLFYMGITFQTKY YLLAIPAGFLFTLFCLYLFIIFFPAFTPRGNTIFRIKTGKNGEVFTDKVSVTFTDIKK IEMSRHKFSLKGIFQEDILIQTVDQKTIRIPTWNIIPNPLFFEAVERYILPHLNEEAK SNWIGQFTDIQRSAYLKEFENHPKL*" gene complement(886775..887332) /gene="yfjD" /locus_tag="BSU_08140" /old_locus_tag="BSU08140" promotor_-35 887198..887203 /Source="Nicolas_upshift_promotors" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 887211 /Source="Nicolas_upshifts" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" promotor_-10 887218..887236 /Source="Nicolas_upshift_promotors" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 887222..887809 /Source="Nicolas_S_feature" /locus_tag="new_887222_887809" /HighExp="S4, S5, S6, S3, S8, S7, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="yfjC" /AntisenseCor="9.3643586039105595E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S283" CDS complement(887364..888131) /gene="yfjC" /locus_tag="BSU_08150" /old_locus_tag="BSU08150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388696.1" /db_xref="EnsemblGenomes-Gn:BSU08150" /db_xref="EnsemblGenomes-Tr:CAB12644" /db_xref="SubtiList:BG12905" /db_xref="UniProtKB/Swiss-Prot:O31556" /translation="MKQFTISIEELLFCFYSEGFFEQGMALKQAYFPEIEDEQLGALF EAACRSLLAKDAAEYRNHQYRLKDEYCPFIHVLNDADYTVKLSKFNGQGAEQNVSCHV SKFGTYSHELLFDEQVHRITKMESSEGLLAKTDEFLHIIDTEDKRESIVTLTSNEFEK LLEGASDNPSYLKEFLEKHDHQEDVTRFANDLALRKGKMDTLMRLAYGKDNTPEVADM AFVLPGAHHTWLVTGITQNEFSILPAHKDVVNQIISK*" gene complement(887364..888131) /gene="yfjC" /locus_tag="BSU_08150" /old_locus_tag="BSU08150" CDS complement(888143..889366) /gene="yfjB" /locus_tag="BSU_08160" /old_locus_tag="BSU08160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388697.1" /db_xref="EnsemblGenomes-Gn:BSU08160" /db_xref="EnsemblGenomes-Tr:CAB12645" /db_xref="SubtiList:BG12904" /db_xref="UniProtKB/Swiss-Prot:O31557" /translation="MSGNIAVDPDKLEQLANDVVTELTDMENKYKDLHVELGQMILQC DPRYSSCFSGVGDAWSSGKALVTKLSDNEIFIRKTGDKFVEQDDILRKLYNAYDKYGT MTSLTALMLTQGKYYGLGLTKFVKQPSGLHTAQHSKLLLDISRAVDSSRYQKAARVLL NPKYLLKKTNRPFSDLVHKKFTKYFPQDTVDFSNSVRSYTKGFLNEAGVRSTLKDVGK TGLRFAKGNAITATLITGATETFGAGVKIAENYAKYQDKPEVLKRENAKAVGNAVNNT IFVAGGATAGAVIGGAIGSFAGPVGTVLLGAAGSYIGGVVGEQIAKYTAGFAEKAALK LKEPIHAVVDTAKKGLESAGKVVKSVNDGIDAANKSIHKGIDSAKKGMEKAKKTADSL IHGATHFLKGKFSFG*" gene complement(888143..889366) /gene="yfjB" /locus_tag="BSU_08160" /old_locus_tag="BSU08160" CDS complement(889372..889686) /gene="yfjA" /locus_tag="BSU_08170" /old_locus_tag="BSU08170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388698.1" /db_xref="EnsemblGenomes-Gn:BSU08170" /db_xref="EnsemblGenomes-Tr:CAB12646" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12903" /db_xref="UniProtKB/Swiss-Prot:O31558" /translation="MDSYKVIELANKYSAAAEEVRSSKMLLESRLSALGDAWQGKARD SFDQDFEETKAAYDQFEQELLETSQELKAAAVKIEERKAEIARMEELERKAREERHKL GR*" gene complement(889372..889686) /gene="yfjA" /locus_tag="BSU_08170" /old_locus_tag="BSU08170" promotor_-10 complement(889734..889753) /Source="Nicolas_upshift_promotors" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(889747) /Source="Nicolas_upshifts" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" promotor_-35 complement(889768..889771) /Source="Nicolas_upshift_promotors" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 889978..889997 /Source="Nicolas_upshift_promotors" /id="U624" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.258741258741259" /psig="0.684315684315684" /xcortree=342 /SigmaFactorBS="cactaaagttgatcaaatgacctaagtgcgccaaacgtgtta cgggacgagctatctCATGGTATAAATGGAATTGTaaacgttatcaaggaggtcgtca t" /listShort="malA, malR, malP, malQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 889981 /Source="Nicolas_upshifts" /id="U624" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.258741258741259" /psig="0.684315684315684" /xcortree=342 /SigmaFactorBS="cactaaagttgatcaaatgacctaagtgcgccaaacgtgtta cgggacgagctatctCATGGTATAAATGGAATTGTaaacgttatcaaggaggtcgtca t" /listShort="malA, malR, malP, malQ" /GFF_Attribute="listLong" CDS 890022..891371 /gene="malA" /locus_tag="BSU_08180" /old_locus_tag="BSU08180" /EC_number="3.2.1.122" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9765262, 10329789, 11489864, 15341727, 15670594, 16707683, 17676871, 20698522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765262, 10329789, 11489864, 15341727, 15670594, 16707683, 17676871, 20698522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-alpha-glucosidase" /protein_id="NP_388699.1" /db_xref="EnsemblGenomes-Gn:BSU08180" /db_xref="EnsemblGenomes-Tr:CAB12647" /db_xref="GOA:P54716" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="PDB:1U8X" /db_xref="SubtiList:BG11839" /db_xref="UniProtKB/Swiss-Prot:P54716" /translation="MKKKSFSIVIAGGGSTFTPGIVLMLLDHLEEFPIRKLKLYDNDK ERQDRIAGACDVFIREKAPDIEFAATTDPEEAFTDVDFVMAHIRVGKYAMRALDEQIP LKYGVVGQETCGPGGIAYGMRSIGGVLEILDYMEKYSPDAWMLNYSNPAAIVAEATRR LRPNSKILNICDMPVGIEDRMAQILGLSSRKEMKVRYYGLNHFGWWTSIQDQEGNDLM PKLKEHVSQYGYIPKTEAEAVEASWNDTFAKARDVQAADPDTLPNTYLQYYLFPDDMV KKSNPNHTRANEVMEGREAFIFSQCDMITREQSSENSEIKIDDHASYIVDLARAIAYN TGERMLLIVENNGAIANFDPTAMVEVPCIVGSNGPEPITVGTIPQFQKGLMEQQVSVE KLTVEAWAEKSFQKLWQALILSKTVPNARVARLILEDLVEANKDFWPELDQSPTRIS* " gene 890022..891371 /gene="malA" /locus_tag="BSU_08180" /old_locus_tag="BSU08180" misc_feature 891400..891419 /Source="Nicolas_upshift_promotors" /id="U625" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3083 /SigmaFactorBS="cttgatcaaagcccaacccgcatatcataaatgaaattcccc cattttcgaatctgtaATTGTATATAATAGAAAGAAaatggggggatctgatatgcag c" /listShort="malR, malP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 891402 /Source="Nicolas_upshifts" /id="U625" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3083 /SigmaFactorBS="cttgatcaaagcccaacccgcatatcataaatgaaattcccc cattttcgaatctgtaATTGTATATAATAGAAAGAAaatggggggatctgatatgcag c" /listShort="malR, malP" /GFF_Attribute="listLong" CDS 891436..892200 /gene="malR" /locus_tag="BSU_08190" /old_locus_tag="BSU08190" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489864, 16707683, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489864, 16707683, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the Mal operon" /protein_id="NP_388700.1" /db_xref="EnsemblGenomes-Gn:BSU08190" /db_xref="EnsemblGenomes-Tr:CAB12648" /db_xref="GOA:P54717" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11847" /db_xref="UniProtKB/Swiss-Prot:P54717" /translation="MQLEELINQHYSKLNDNDFHILKYILNHKHTCYHLGIDALAKAC SVSRSSILRLAQKLGFSGYSEFRVFLKWEDQPEEGESMSFEKLLDDIEANLKFLRTKD MTDMCQLIDAADRIFVYGSGNAQKICARDLQRMFIPRHRYLILIEDTNEFNLMRDDFK VNDLFIIISLSGETPELIPQARMLSAKGIPFISITNLKNNVLAQLTPHNLYATSKPVT LSDRTEIVAFAPFFLVGEALFRAYVDYKEAEKNDNE*" gene 891436..892200 /gene="malR" /locus_tag="BSU_08190" /old_locus_tag="BSU08190" promotor_-10 complement(891580..891594) /Source="Nicolas_upshift_promotors" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(891610..891616) /Source="Nicolas_upshift_promotors" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(891610) /Source="Nicolas_upshifts" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 892215..893798 /gene="malP" /locus_tag="BSU_08200" /old_locus_tag="BSU08200" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) maltose-specificenzyme IICB component" /protein_id="NP_388701.1" /db_xref="EnsemblGenomes-Gn:BSU08200" /db_xref="EnsemblGenomes-Tr:CAB12649" /db_xref="GOA:P54715" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010975" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11848" /db_xref="UniProtKB/Swiss-Prot:P54715" /translation="MMQKIQRFGSAMFVPVLLFAFAGIIVGISTLFKNKTLMGPLADP DGFWYQCWYIIEQGGWTVFNQMPLLFAIGIPVALAKKAQARACLEALTVYLTFNYFVS AILTVWGGAFGVDMNQEVGGTSGLTMIAGIKTLDTNIIGAIFISSIVVFLHNRYFDKK LPDFLGIFQGSTYIVMISFFIMIPIALAVSYIWPMVQSGIGSLQSFLVASGAVGVWIY TFLERILIPTGLHHFIYTPFIYGPAVAEGGIVTYWAQHLGEYSQSAKPLKELFPQGGF ALHGNSKIFGIPGIALAFYVTAKKEKKKLVAGLLIPVTLTAIVAGITEPIEFTFLFIS PFLFAVHAVLAATMSTVMYMAGVVGNMGGGLIEAVTLNWIPLFGSHGMTYVYQILIGL SFTAIYFFVFRFLILKFNIATPGREKDEQQETKLYSKKEYRERKNKDETASAAETADD TAFLYIEALGGKDNITEVTNCATRLRVSVKDETKVEPDSVFRALGAHGVVRNGKAFQV IIGLSVPQMRERVEKILNQ*" gene 892215..893798 /gene="malP" /locus_tag="BSU_08200" /old_locus_tag="BSU08200" downshifts 893778 /Source="Nicolas_upshifts" /id="D409" /incds=0 /nref=23 /ntot=46 /MaxReadThrough="3.26652" /MaxDrop="4.69656" /score="8.65399085" /energy="-10.9" /TU="U624" /idTUdmin="U625" /TUdmin=836 /isTUend="FALSE" promotor_-35 893827..893834 /Source="Nicolas_upshift_promotors" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 893849..893868 /Source="Nicolas_upshift_promotors" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 893857 /Source="Nicolas_upshifts" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" CDS 893904..895625 /gene="yfiB" /locus_tag="BSU_08210" /old_locus_tag="BSU08210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative xenobiotic ABC transporter subunit (ATP-binding protein)" /protein_id="NP_388702.1" /db_xref="EnsemblGenomes-Gn:BSU08210" /db_xref="EnsemblGenomes-Tr:CAB12650" /db_xref="GOA:P54718" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11849" /db_xref="UniProtKB/Swiss-Prot:P54718" /translation="MQKALSFLKPYSLLAGIALILMLTELAVELMQPLLIAKIIDDGI LKQDLRHVWIWGTVMIGLTVLSFAAGMLNSFYAAHVSQSFSYDTRKGLFQKIQSFSYS TFGQFSSSSYITRLTNDVTQVQNMIFMSLRFMLRAPLMIAGGIVLSLAVNVKLGFFLL VTIPILILFLLWVLRKGGALFRSVQKRLDQVNTIMQENLIAIKLIKALLRGSHEVKRF IKANTRLMEKTVSAFQLVEFTMPVLMLLMNLCILLILWAGSYSITSGSTQVGDVVAII NYATRITGALSMFPFLIMIFTRAKASGDRIGEVLETEGDEREEGTISDRLSGRIEFQH VSFRYPEMDREALRNVSFSAKPRETIAILGATGSGKSTLFQLIPRLYQPDSGRIYIDE KPVQDIPAEGLRRQIGYVPQEVLLFSGTIKENIAWGKENASLDEIMDAAKLAQIHETI LKLPNGYDTVLGQRGVNLSGGQKQRISIARALIRKPAILLLDDSTSALDLQTEAKLLE AISTYHCTTLIITQKITTAMKADQILLLEDGELIEKGTHSELLSESQLYKRIYESQFG REGSESC*" gene 893904..895625 /gene="yfiB" /locus_tag="BSU_08210" /old_locus_tag="BSU08210" CDS 895619..897433 /gene="yfiC" /locus_tag="BSU_08220" /old_locus_tag="BSU08220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388703.1" /db_xref="EnsemblGenomes-Gn:BSU08220" /db_xref="EnsemblGenomes-Tr:CAB12651" /db_xref="GOA:P54719" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11850" /db_xref="UniProtKB/Swiss-Prot:P54719" /translation="MLKDIRKPFQYPKLPIDKKEGAKKRAKAKDTKGTLRRIWSYLAE RKGLLILVMLMVVISAIFGLLGPFVIGKAIDHFIVGKTVSGLIPVLLLLLAIYIIQSL SLWFQNYWMITISQGTVFRMRSELFTHLHELPIPFFDKQRHGELMSRVTNDIENVSST LNTSVIQILSSVITFVGTIAVMLYMSPLLTLITLTIIPVMAASLKWITNRTGKLFKEQ QKNLGDLNGYIEESVSGAKVIKAYSREKQITAEFLEKNAALKTSGFWAQTISGFIPKV MNSLNNLSFTMIAAIGGLFALKGWISIGSIVVFAEYSRQFTRPLNDLANQFNTMLSAI AGAERVFDVLDEKEEREDEKNAVHQPIQTGSIEFRDVSFGYDKGQQTLKHLQFTVPAG QSIAFVGPTGAGKTTVTNLLARFYEPNDGKILIDGTDIKTLTRASLRKNMGFVLQDSF LFQGTIRENIRYGRLDASDQEVEAAAKTANAHSFIERLPKGYDTVLTQNGSGISQGQK QLISIARAVLADPVLLILDEATSNIDTVTEVNIQEALARLMEGRTSVIIAHRLNTIQR ADQIVVLKNGEMIEKGSHDELIRQKGFYSDLYESQFEK*" gene 895619..897433 /gene="yfiC" /locus_tag="BSU_08220" /old_locus_tag="BSU08220" downshifts 897408 /Source="Nicolas_upshifts" /id="D410" /incds=0 /nref=103 /ntot=190 /MaxReadThrough="2.4559" /MaxDrop="5.61906" /score="24.4395842" /energy="-11" /TU="NA" /idTUdmin="U627" /TUdmin=0 /isTUend="TRUE" promotor_-35 897515..897522 /Source="Nicolas_upshift_promotors" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 897536..897555 /Source="Nicolas_upshift_promotors" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 897540 /Source="Nicolas_upshifts" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" CDS 897588..897992 /gene="catD" /locus_tag="BSU_08230" /old_locus_tag="BSU08230" /EC_number="1.13.11.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16872404, 16850406, 17407181, 20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16872404, 16850406, 17407181, 20639328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catechol-2,3-dioxygenase membrane subunit" /protein_id="NP_388704.1" /db_xref="EnsemblGenomes-Gn:BSU08230" /db_xref="EnsemblGenomes-Tr:CAB12652" /db_xref="GOA:P54720" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG11851" /db_xref="UniProtKB/Swiss-Prot:P54720" /translation="MNKSFEIGTLLLRVITGIIFFVHGLSKFQGMEGTIQFFGSIGLP SFMAYVIAAIELIGGVLVFFGLATRIVGVLFALTLIGAIITVKLKAPFMGNAEFDYLL LLTSIHLALTGSRFLALDPFVFKGKKNGNVSA*" gene 897588..897992 /gene="catD" /locus_tag="BSU_08230" /old_locus_tag="BSU08230" CDS 898010..898867 /gene="catE" /locus_tag="BSU_08240" /old_locus_tag="BSU08240" /EC_number="1.13.11.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17407181, 16872404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 16872404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catechol-2,3-dioxygenase subunit" /protein_id="NP_388705.2" /db_xref="EnsemblGenomes-Gn:BSU08240" /db_xref="EnsemblGenomes-Tr:CAB12653" /db_xref="GOA:P54721" /db_xref="InterPro:IPR000486" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11852" /db_xref="UniProtKB/Swiss-Prot:P54721" /translation="MTSIHEDTHIGYAKLTIRSLERSLQFYCNVIGFQVLKKTDRQAE LTADGKRVLLILEENPSAVVLPERSVTGLYHFAILLPDRKELGIALARLIEHGIAIGH GDHAVSEALYLSDPDGNGIEMYADRPRSTWQRDREGNYVMTTTAVDIEGLLEEAGDER KTSLPNDTIIGHIHLHVSDLKEAKAFYTDVLGFDIVGNYAGMSALFVSAGGYHHHIGL NIWAGRNAPPKPTNASGLDYYTVVLPHQEELDLVANRVKHAGYSIEETENSFRVKDPV SGAYITFVI*" gene 898010..898867 /gene="catE" /locus_tag="BSU_08240" /old_locus_tag="BSU08240" downshifts 898854 /Source="Nicolas_upshifts" /id="D411" /incds=0 /nref=4 /ntot=21 /MaxReadThrough="0.66359" /MaxDrop="3.74886" /score="50.8573531" /energy="-19.7" /TU="NA" /idTUdmin="U628" /TUdmin=16 /isTUend="TRUE" CDS 898961..899905 /gene="yfiF" /locus_tag="BSU_08250" /old_locus_tag="BSU08250" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family; cupin family)" /protein_id="NP_388706.1" /db_xref="EnsemblGenomes-Gn:BSU08250" /db_xref="EnsemblGenomes-Tr:CAB12654" /db_xref="GOA:P54722" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11853" /db_xref="UniProtKB/Swiss-Prot:P54722" /translation="MELNHLVTGKIALNQYVHRLEQKDVSFYVHYWGAMTNHYNTLLH KHSFYEICYVVRGEGYYLEGDRTYPLREQTIFLSKPEHLHQIKSETGLFLFYVAFELS EDQSSAEWIKVMEEVKQSPFITMQLKDGEPPGLLWKTLMLQAAQPVNAFDKEILSHLS HALILSLIQTFLPYAQRPKQKQPIHTSSALLTEVKLHIKDNLSQPLKLTDVASHFHIS GRHLSRLFAAELGVSYSEFVQNEKINKAAELLKSTNLSIKEIAEEIGFSVHYFTRVFS AKIGSSPGLFRSLYKDSKMTAFQINKPFQKIEQAKPHE*" gene 898961..899905 /gene="yfiF" /locus_tag="BSU_08250" /old_locus_tag="BSU08250" downshifts complement(899772) /Source="Nicolas_upshifts" /id="D412" /incds=1 /nref=1 /ntot=2 /MaxReadThrough="-0.20031" /MaxDrop="3.51831" /score="-4.19869956" /energy="-9.5" /TU="NA" /idTUdmin="U632" /TUdmin=9372 /isTUend="FALSE" promotor_no_box complement(899820..899920) /Source="Nicolas_upshift_promotors" /id="U629" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.533466533466533" /psig="0.034965034965035" /xcortree=1481 /SigmaFactorBS="tcatttcaggacatcttattcgtgcggcttggcctgttcgat tttttgaaaaggtttattgatttgaaatgcggtcatttttgagtctttataaagggag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(899860) /Source="Nicolas_upshifts" /id="U629" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.533466533466533" /psig="0.034965034965035" /xcortree=1481 /SigmaFactorBS="tcatttcaggacatcttattcgtgcggcttggcctgttcgat tttttgaaaaggtttattgatttgaaatgcggtcatttttgagtctttataaagggag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 900080..901528 /gene="yfiG" /locus_tag="BSU_08260" /old_locus_tag="BSU08260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar/proton transporter" /protein_id="NP_388707.1" /db_xref="EnsemblGenomes-Gn:BSU08260" /db_xref="EnsemblGenomes-Tr:CAB12655" /db_xref="GOA:P54723" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11854" /db_xref="UniProtKB/Swiss-Prot:P54723" /translation="MSTKKKEAVIGKESLAHKGLLRTITLVSTFGGLLFGYDTGVING ALPFMATAGQLNLTPVTEGLVASSLLLGAAFGAMFGGRLSDRHGRRKTILYLALLFIA ATLGCTFSPNASVMIAFRFLLGLAVGCASVTVPTFLAEISPAERRGRIVTQNELMIVI GQLLAYTFNAIIGSTMGESANVWRYMLVIATLPAVVLWFGMLIVPESPRWLAAKGRMG DALRVLRQIREDSQAQQEIKEIKHAIEGTAKKAGFHDFQEPWIRRILFIGIGIAIVQQ ITGVNSIMYYGTEILREAGFQTEAALIGNIANGVISVIAVIFGIWLLGKVRRRPMLII GQIGTMTALLLIGILSIVLEGTPALPYVVLSLTILFLAFQQTAISTVTWLMLSEIFPM HVRGLGMGISTFCLWTANFLIGFTFPILLNHIGMSATFFIFVAMNILAILFVKKYVPE TKGRSLEQLEHSFRQYGRRADQEIQNQTTHLS*" gene 900080..901528 /gene="yfiG" /locus_tag="BSU_08260" /old_locus_tag="BSU08260" CDS 901555..902496 /gene="yfiH" /locus_tag="BSU_08270" /old_locus_tag="BSU08270" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar-phosphate epimerase/isomerase" /protein_id="NP_388708.1" /db_xref="EnsemblGenomes-Gn:BSU08270" /db_xref="EnsemblGenomes-Tr:CAB12656" /db_xref="InterPro:IPR011418" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11855" /db_xref="UniProtKB/Swiss-Prot:P54724" /translation="MKLSYVTDSLGHLPFEDMLNFAAKLGIDTLEMTTGGWSPAPHLN LDELLQSSEKRKEFSQALEKRNMTLCALNCSGNPLDPGELGKSHRDITDKTMELAGLL GVKKVIMMSGLPAGGPDDKVPNWITYTVSWPPVLKDILNYQWEDVAIPYWKKLVKKAE ACGVGKIALENFSSQLVYNPETLFRLRNAVGPMVGLNLDPSHLLWMGADPIIAARELG SAIHHVHGKDVRIERYLSAVNGLLETKEVTDPANRAWNYVAVGCGQDLQWWKEFFSVV KMMGYEGEVSLEMEDLTMSPEAGIRTSVEALKQTISQ*" gene 901555..902496 /gene="yfiH" /locus_tag="BSU_08270" /old_locus_tag="BSU08270" CDS 902506..903687 /gene="yfiI" /locus_tag="BSU_08280" /old_locus_tag="BSU08280" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26438878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388709.1" /db_xref="EnsemblGenomes-Gn:BSU08280" /db_xref="EnsemblGenomes-Tr:CAB12657" /db_xref="GOA:P94437" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12214" /db_xref="UniProtKB/Swiss-Prot:P94437" /translation="MMLNGERIISKPLRWAMVGGGRLSQVGYKHRIGALRDNTAFQLT AGAFDIDAERGKDFGVNLGVDAERCYPNYQTMFAEEAKRQDGIEVVSIATPNGTHYEI CKAALEAGVHVICEKPLFFTSAEGQEIKALAEKKGKIVGVTYGFSGNQMLLQMRAMIE QGMIGDIRVVDLQYTHGFCATDEGEKISAAQKWRVDPAIAGPSFVLGDLSTHTYYMSQ LIMPKMKIKELLCDRQSFVGSRAPLEDNAHVLMHYENGAVGTMWTSSINAGCMDGHRI RIVGSKASIEWWDSKPNELTYEVQGEPGQTLVRGMPYLDDVCNADERLGALHSEGLSE AWANIYLKFAIAIDAKNREDEEILNNLVYPDIDAGIEGIRWIENCVRSANQGSVWVEF K*" gene 902506..903687 /gene="yfiI" /locus_tag="BSU_08280" /old_locus_tag="BSU08280" downshifts 903677 /Source="Nicolas_upshifts" /id="D413" /incds=0 /nref=40 /ntot=113 /MaxReadThrough="0.88387" /MaxDrop="5.80704" /score="14.819468" /energy="-13" /TU="NA" /idTUdmin="U630" /TUdmin="-2003" /isTUend="FALSE" promotor_-35 903747..903753 /Source="Nicolas_upshift_promotors" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 903768..903787 /Source="Nicolas_upshift_promotors" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 903786 /Source="Nicolas_upshifts" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" CDS 903811..905013 /gene="linJ" /locus_tag="BSU_08290" /old_locus_tag="BSU08290" /function="16.12: Sense" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11717295, 12618459, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12618459, 28461449; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LinK] (linearmycin resistance, biofilm formation)" /protein_id="NP_388710.1" /db_xref="EnsemblGenomes-Gn:BSU08290" /db_xref="EnsemblGenomes-Tr:CAB12658" /db_xref="GOA:P94438" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12215" /db_xref="UniProtKB/Swiss-Prot:P94438" /translation="MKALFFTRMFTLMVSCLMYLSIVKEDNWFGYVFIAAGAAMYAAN HVLLTKETNAIWFCLIDIAIGFSFGFIFPGTGLFIIMLCPVAVAFFLRGFPKRTAWSV LCLSSILFLTVLIRTYAMFGNEFVIDHLTSMTFVVFCGVVGKLIRKLLDAQDTAKQQF QELTESHLALSAAHQELHLYAKQVEELTAIYERNRMAREIHDTVGHKMTALLVQLQLL REWQKRDSQKADETVGVCETLAREALDDVRLSVRTLQTENDPSLIESLKQLTEDFCKN AGVTTEFAVSGDPAIIPLSLHPTLIRTVQEALTNAKRHGGAAACSIQLACTTDSISLV IKDDGKGNPEAALGFGLLNMKKRAAEHGGMIRFESERDQGFTVNAEFSLANKKWSFGP VQQKESLS*" gene 903811..905013 /gene="linJ" /locus_tag="BSU_08290" /old_locus_tag="BSU08290" CDS 905010..905672 /gene="linK" /locus_tag="BSU_08300" /old_locus_tag="BSU08300" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12618459, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12618459, 28461449; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LinJ] (linearmycin resistance, biofilm formation)" /protein_id="NP_388711.1" /db_xref="EnsemblGenomes-Gn:BSU08300" /db_xref="EnsemblGenomes-Tr:CAB12659" /db_xref="GOA:P94439" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12216" /db_xref="UniProtKB/Swiss-Prot:P94439" /translation="MIKIIITDDQDIVREGLASLLQLREELDVIATARNGQEAFEKAK ELEPDIVLMDIRMPVSNGVEGTKLITSSLPSVKVLMLTTFKDSALIAEALEEGASGYL LKDMSADTIVKAVMTVHSGGMVLPPELTAQMLNEWKREKQLKGINEIEKPNELLDLTE REIEVLAELGYGLNNKEIAEKLYITEGTVKNHVSNIISKLAVRDRTQAAIYSVRYGVS VF*" gene 905010..905672 /gene="linK" /locus_tag="BSU_08300" /old_locus_tag="BSU08300" downshifts 905680 /Source="Nicolas_upshifts" /id="D414" /incds=0 /nref=114 /ntot=229 /MaxReadThrough="-0.0105699999999995" /MaxDrop="4.23231" /score="20.4785449" /energy="-7.6" /TU="NA" /idTUdmin="U630" /TUdmin=0 /isTUend="TRUE" CDS 905816..906751 /gene="bifL" /locus_tag="BSU_08310" /old_locus_tag="BSU08310" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) biofilm formation" /protein_id="NP_388712.2" /db_xref="EnsemblGenomes-Gn:BSU08310" /db_xref="EnsemblGenomes-Tr:CAB12660" /db_xref="GOA:P94440" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12217" /db_xref="UniProtKB/Swiss-Prot:P94440" /translation="MLQAENIKKAYGKKTIVKGISFSLKKGESFGLLGPNGAGKSTTI SMISGLVPHDSGNITVGGYVIGKETAKAKQKIGIVPQEIALYPTLTAHENLMFWGKMY GLTHGEAKKRAAEVLEYVGLTERAKDKIETFSGGMKRRINIGAALMHKPELLIMDEPT VGIDPQSRNHILETVKQLNETGMTVIYTSHYMEEVEFLCDRIGIIDQGEMIAIGTKTD LCSRLGGDTIIQLTVSGINEAFLVAIRSLAHVNDVTVHELELKIDISAAHHEKVVTSL LAEATAHHINLLSLQVQEPNLERLFLNLTGRTLRD*" gene 905816..906751 /gene="bifL" /locus_tag="BSU_08310" /old_locus_tag="BSU08310" CDS 906764..907954 /gene="bifM" /locus_tag="BSU_08320" /old_locus_tag="BSU08320" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) biofilm formation" /protein_id="NP_388713.1" /db_xref="EnsemblGenomes-Gn:BSU08320" /db_xref="EnsemblGenomes-Tr:CAB12661" /db_xref="GOA:P94441" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12218" /db_xref="UniProtKB/Swiss-Prot:P94441" /translation="MKKSIWIAWKDVKIRITDRKGFMMLILMPLILTCILGAALGSVV DGGSRIDDIKVGYIQSDQSDTANMFTKDVLKKMKSIKVTKVGSKDKMKKLIDEKKIDV GIVIPNHWEAGKTSAVVNAAPDQTLKSSIIETAASSFIEQYKAVKEAASGSMDYISKT EAVKQGKLDPAQFAEKLAKTLEKETGDKLTIAEKSVGSKAVTSFQYYSAAMLCMFMLF HITVGAKSFLQEKDTETLARMLMTPAQKSVILFGKWLGTYLFAIIQFFIFLIVTINVF GVDWGGNLLLVSVLGLSYAAAVSGISMLLASCISDMKTADAIGGFGIQLLAVLGGSML PLYQFPDVLQSVSKAVPNRWALDGFLSLMEGGGWADLQKPVLLFAAIGFCSLVIGIRR LHTR*" gene 906764..907954 /gene="bifM" /locus_tag="BSU_08320" /old_locus_tag="BSU08320" CDS 907968..909125 /gene="bifN" /locus_tag="BSU_08330" /old_locus_tag="BSU08330" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) biofilm formation" /protein_id="NP_388714.1" /db_xref="EnsemblGenomes-Gn:BSU08330" /db_xref="EnsemblGenomes-Tr:CAB12662" /db_xref="GOA:P94442" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12219" /db_xref="UniProtKB/Swiss-Prot:P94442" /translation="MKKILAICGIELSLIFKKPQNYLIMFAAPLLLTFVFGSMLSGND DKVRLAIVDQDDTILSQHYIRQLKAHDDMYVFENMSESKASEKLKQKKIAGIIVISRS FQTQLEKGKHPELIFRHGPELSEAPMVKQYAESALATLNIQVTAAKTASQTAGENWKA AYKTVFAKKHEDIVPAVTRQTLSDKKEGAEASDTASRAAGFSILFVMLTMMGAAGTIL EARKNGVWSRLLTASVSRAEIGAGYVLSFFVIGWIQFGILLLSTHWLFGINWGNPAAV IVLVSLFLLTVVGIGLMIAANVRTPEQQLAFGNLFVIATCMVSGMYWPIDIEPKFMQS IAEFLPQKWAMSGLTEIIANGARVTDILGICGILLAFAAITFAAGLKALRA*" gene 907968..909125 /gene="bifN" /locus_tag="BSU_08330" /old_locus_tag="BSU08330" promotor_-35 908079..908084 /Source="Nicolas_upshift_promotors" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 908099..908117 /Source="Nicolas_upshift_promotors" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 908100 /Source="Nicolas_upshifts" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(909123..909197) /Source="Nicolas_S_feature" /locus_tag="new_909123_909197_c" /HighExp="LoTm, Sw, C90, HiOs, BC, MG 45, UNK1, Fru, S1, BI" /AntisenseName="yfiN" /AntisenseCor="-6.3486715356968801E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S284" downshifts complement(909166) /Source="Nicolas_upshifts" /id="D415" /incds=0 /nref=90 /ntot=257 /MaxReadThrough="1.41433" /MaxDrop="6.01369" /score="13.7314837" /energy="-11.5" /TU="U632" /idTUdmin="U632" /TUdmin="-22" /isTUend="TRUE" CDS complement(909198..909746) /gene="padR" /locus_tag="BSU_08340" /old_locus_tag="BSU08340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of phenolic acid decarboxylase" /protein_id="NP_388715.1" /db_xref="EnsemblGenomes-Gn:BSU08340" /db_xref="EnsemblGenomes-Tr:CAB12663" /db_xref="GOA:P94443" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR018309" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12220" /db_xref="UniProtKB/Swiss-Prot:P94443" /translation="MRVLKYAILGLLRKGELSGYDITSYFKEELGQFWSAKHSQIYPE LKKLTDEGFITFRTTIQGTKLEKKMYTLTDSGKQELHDWLIRHQPIPETVKDEFMLKA YFISCLSRQEASDLFKDQLQKRQAKLSDLQGSYEKLMASAEPMSFSSPDFGHYLVLTK ALEREKNYVSWLESILAMIDKD*" gene complement(909198..909746) /gene="padR" /locus_tag="BSU_08340" /old_locus_tag="BSU08340" S_feature complement(909747..909826) /Source="Nicolas_S_feature" /locus_tag="new_909747_909826_c" /HighExp="LoTm, Cold, G180, GM-0.2, Oxctl, T5.0H, GM 25, T3.30H, MG 60, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S285" promotor_-10 complement(909815..909834) /Source="Nicolas_upshift_promotors" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(909826) /Source="Nicolas_upshifts" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" promotor_-35 complement(909848..909853) /Source="Nicolas_upshift_promotors" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 909949..909952 /Source="Nicolas_upshift_promotors" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 909968..909987 /Source="Nicolas_upshift_promotors" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 909975 /Source="Nicolas_upshifts" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" CDS 910019..910651 /gene="estB" /locus_tag="BSU_08350" /old_locus_tag="BSU08350" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11029590, 10913700, 21574267" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11029590, 10913700, 21574267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted esterase / acylglycerol lipase" /protein_id="NP_388716.1" /db_xref="EnsemblGenomes-Gn:BSU08350" /db_xref="EnsemblGenomes-Tr:CAB12664" /db_xref="GOA:Q79F14" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11951" /db_xref="UniProtKB/Swiss-Prot:Q79F14" /translation="MKKVLMAFIICLSLILSVLAAPPSGAKAESVHNPVVLVHGISGA SYNFFAIKNYLISQGWQSNKLYAIDFYDKTGNNLNNGPQLASYVDRVLKETGAKKVDI VAHSMGGANTLYYIKYLGGGNKIQNVVTLGGANGLVSSTALPGTDPNQKILYTSIYSL NDQIVINSLSRLQGARNIQLYGIGHIGLLSNSQVNGYIKEGLNGGGLNTN*" gene 910019..910651 /gene="estB" /locus_tag="BSU_08350" /old_locus_tag="BSU08350" downshifts 910630 /Source="Nicolas_upshifts" /id="D416" /incds=0 /nref=7 /ntot=100 /MaxReadThrough="0.87881" /MaxDrop="2.6151" /score="0.223019698" /energy="-8.5" /TU="NA" /idTUdmin="U633" /TUdmin=88 /isTUend="FALSE" promotor_-35 910766..910771 /Source="Nicolas_upshift_promotors" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 910785..910804 /Source="Nicolas_upshift_promotors" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 910795 /Source="Nicolas_upshifts" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" CDS 910840..911928 /gene="icaC" /locus_tag="BSU_08360" /old_locus_tag="BSU08360" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 24776724, 25935415, 27303652; Product type t : transporter" /codon_start=1 /transl_table=11 /product="acetyl-glucosamine metabolite exporter componentinvolved in biofilm formation" /protein_id="NP_388717.1" /db_xref="EnsemblGenomes-Gn:BSU08360" /db_xref="EnsemblGenomes-Tr:CAB12665" /db_xref="GOA:O31559" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG12893" /db_xref="UniProtKB/Swiss-Prot:O31559" /translation="MQIKEIFMIRCISCLSVVLLHIISMVLMLQAEALADISHTVDSF RTLLMFSTPAFIFISEFLLARSYPDGVPDGFLKKRGKVIFVPFLFIAAIDALLMTSAM GGEVTFLAFVQKYLANVFLGNFIGYFILVIFQFYMLHMMFHEYLKKASPKWVLSISFV VTAAYLGYFSAASPAPASEEGGAFPFFWVPFAGWLFYFCLAYYCGKEYKRFLALLNQY RWVVYGAAIASGALVVTVSYVGEIGMISSKRPDIMLYSTSMIFLCFHLFSKMKHVPKI MMFISNYSFSIYLLHAYFMIIGYVLLLNMPEIPAVPAVLLLFAVCTAGPIMTSWALNK FKYGYLFVGKIYQPKQKKVTVEVRDHAG*" gene 910840..911928 /gene="icaC" /locus_tag="BSU_08360" /old_locus_tag="BSU08360" S_feature complement(911330..911718) /Source="Nicolas_S_feature" /locus_tag="new_911330_911718_c" /HighExp="S6, S8, S7, S5, LBGstat, H2O2, Mt0, Cold, G180, LPhT" /AntisenseName="yfiQ" /AntisenseCor="0.36913176163336098" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.976" /TUlongSig="NA" /TUlongPSig="NA" /label="S286" upshifts complement(911718) /Source="Nicolas_upshifts" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" promotor_-10 complement(911720..911739) /Source="Nicolas_upshift_promotors" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(911752..911760) /Source="Nicolas_upshift_promotors" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(911964..912581) /gene="yfiR" /locus_tag="BSU_08370" /old_locus_tag="BSU08370" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16862575" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16862575; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388718.1" /db_xref="EnsemblGenomes-Gn:BSU08370" /db_xref="EnsemblGenomes-Tr:CAB12666" /db_xref="GOA:O31560" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1RKT" /db_xref="SubtiList:BG12894" /db_xref="UniProtKB/Swiss-Prot:O31560" /translation="MSPKVTKEHKDKRQAEILEAAKTVFKRKGFELTTMKDVVEESGF SRGGVYLYFSSTEEMFRRIIETGLDEGLRKLDKSAEHQSVWASISSYLDELTEGLRDV ADTLAPVQFEYLVTAWRNEERRQYLEKRYDLFVERFSRLLQKGIDQGEFQPVQPLATI AKFFLNMNDGIIQNALYFDEEKADVSGLAESAKLYLKTVLQADEK*" gene complement(911964..912581) /gene="yfiR" /locus_tag="BSU_08370" /old_locus_tag="BSU08370" downshifts complement(911982) /Source="Nicolas_upshifts" /id="D417" /incds=0 /nref=29 /ntot=209 /MaxReadThrough="2.44114" /MaxDrop="4.07715" /score="22.1532141" /energy="-17.1" /TU="NA" /idTUdmin="U636" /TUdmin=0 /isTUend="TRUE" CDS complement(912547..913800) /gene="yfiS" /locus_tag="BSU_08380" /old_locus_tag="BSU08380" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811639, 15849754, 16850406, 16862575; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388719.1" /db_xref="EnsemblGenomes-Gn:BSU08380" /db_xref="EnsemblGenomes-Tr:CAB12667" /db_xref="GOA:O31561" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12895" /db_xref="UniProtKB/Swiss-Prot:O31561" /translation="MEKPLFRNQKGLMTLLASQTISSLGDWLHILAVLTLAAFQLHAS PLDMSLLMMSFALPVIVLGPVSGLLADRFDRKTIMFLSEIGRALTVISCVYVSELWQL YVLLSVQSCFSSLFLPAKNGKLKELAPEAHIQQAVSVSSIIDNSSKIFGPALGGTLIA AFSIHSVFYINAGAFFLSAVILFFLPRDAFLQKANTPQEKTAALTSIKEGLQFLKRMP LLLTGLLTACVVLFVLQIGDSQAIILIRSFSGAPPELAGWCMAVSGAGMLLTAAITGR RRITSYLLYFSAGTLLLGLATGGAPFLSGMGIAGITLFIFAFFIMGAAFGLVHIPFQI LVQTTVPVDYSGRVFGAIQSATTLASILGMAGGGVLAEWIGVSLAFLVCGCLLIMIGL ITLIGKKIAESRRYLVTKSNKGAQG*" gene complement(912547..913800) /gene="yfiS" /locus_tag="BSU_08380" /old_locus_tag="BSU08380" promotor_-10 complement(912608..912627) /Source="Nicolas_upshift_promotors" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(912620) /Source="Nicolas_upshifts" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" promotor_-35 complement(912641..912648) /Source="Nicolas_upshift_promotors" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(913834..913853) /Source="Nicolas_upshift_promotors" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(913852) /Source="Nicolas_upshifts" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(913868..913875) /Source="Nicolas_upshift_promotors" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 913879..913898 /Source="Nicolas_upshift_promotors" /id="U638" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.98901098901099" /xcortree=3204 /SigmaFactorBS="atgacactagtgtcgtttttaattgtatgggaaaaagacaca atatacaatctttTTCTTGTAAAATAAAGGAGAagattgaatagaagggagaacattc a" /listShort="yfiT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 913884 /Source="Nicolas_upshifts" /id="U638" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.98901098901099" /xcortree=3204 /SigmaFactorBS="atgacactagtgtcgtttttaattgtatgggaaaaagacaca atatacaatctttTTCTTGTAAAATAAAGGAGAagattgaatagaagggagaacattc a" /listShort="yfiT" /GFF_Attribute="listLong" CDS 913924..914460 /gene="bstA" /locus_tag="BSU_08390" /old_locus_tag="BSU08390" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15581359, 22059487, 24821014, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15581359, 22059487, 24821014, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol S-transferase" /protein_id="NP_388720.1" /db_xref="EnsemblGenomes-Gn:BSU08390" /db_xref="EnsemblGenomes-Tr:CAB12668" /db_xref="GOA:O31562" /db_xref="InterPro:IPR023774" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="PDB:1RXQ" /db_xref="SubtiList:BG12896" /db_xref="UniProtKB/Swiss-Prot:O31562" /translation="MTSVNLSYPIGEYKPRESISKEQKDKWIQVLEEVPAKLKQAVEV MTDSQLDTPYRDGGWTVRQVVHHLADSHMNSYIRFKLSLTEETPAIRPYDEKAWSELK DSKTADPSGSLALLQELHGRWTALLRTLTDQQFKRGFYHPDTKEIITLENALGLYVWH SHHHIAHITELSRRMGWS*" gene 913924..914460 /gene="bstA" /locus_tag="BSU_08390" /old_locus_tag="BSU08390" CDS complement(914457..916013) /gene="yfiU" /locus_tag="BSU_08400" /old_locus_tag="BSU08400" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388721.1" /db_xref="EnsemblGenomes-Gn:BSU08400" /db_xref="EnsemblGenomes-Tr:CAB12669" /db_xref="GOA:O31563" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12897" /db_xref="UniProtKB/Swiss-Prot:O31563" /translation="MSEALTEQKSQKWAISLFTIGVFMAALDNGIISAALTTINESFS VSPSWGSWGITLYTLGLSVSVPIVGKLSDRYGRKKLFLIEVCLFGLGSLLVALSQSFP LFLISRLIQALGGGGIFIIGSSHILATLPKEKQGKALGLLGAMNGMAAVLGPNIGSFL LDWTGSWHWLFLINLPIAVLLVVFGACFIAETKAPEAKRLDAAGIFLLSLSILAVMYG MTNLDGANLLHSLGNPEVYGCIIFGILCFAALISYEKRVEMRGGDPILAYSLLRNHMF QRTLIIGLLSGGLLAAVIFIPSYVEQYLGVPAAKAGYWMTPLALASGIGAWLGGALTD KKGPVKTVILSGIISCAGFALFPLWVTEKWEFVIASVAAGIGFGFLLGAPLNVLVSEA AKTNKGTALGTLSLVRQIGLTLAPTLYAGFITAGFDQIGDEINSRLSDSGYSEKAMQM IPEIDSSEVSSLQEQIERIPVPEVKTAISDAIHASVASGYDHLYAAAAVVSLLVIAAI SIPAFRRQKR*" gene complement(914457..916013) /gene="yfiU" /locus_tag="BSU_08400" /old_locus_tag="BSU08400" promotor_-10 complement(916035..916053) /Source="Nicolas_upshift_promotors" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(916052) /Source="Nicolas_upshifts" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(916069..916072) /Source="Nicolas_upshift_promotors" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(916124..916606) /gene="yfiV" /locus_tag="BSU_08410" /old_locus_tag="BSU08410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18990441; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_388722.1" /db_xref="EnsemblGenomes-Gn:BSU08410" /db_xref="EnsemblGenomes-Tr:CAB12670" /db_xref="GOA:O31564" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12898" /db_xref="UniProtKB/Swiss-Prot:O31564" /translation="MEYNLHDTTVLNENILSSEEREIWVLYMKVLTSAGLGDVSEWMK LDMSMPQMKVLMLLNNHGTLKVSDIAEKMGASLSNTTGLLDRLEKSGFVKRSHSEEDR RSVVVQLTENAKKIFRGLYEKGHLKLKRSLELLSPEEKQAVYEGLSILSRALENAKKE *" gene complement(916124..916606) /gene="yfiV" /locus_tag="BSU_08410" /old_locus_tag="BSU08410" downshifts complement(916140) /Source="Nicolas_upshifts" /id="D418" /incds=0 /nref=58 /ntot=177 /MaxReadThrough="1.47849" /MaxDrop="4.15907" /score="27.2704527" /energy="-14.2" /TU="NA" /idTUdmin="U640" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(916631..916650) /Source="Nicolas_upshift_promotors" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(916647) /Source="Nicolas_upshifts" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" promotor_-35 complement(916665..916671) /Source="Nicolas_upshift_promotors" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 916692..916699 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 916713..916732 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 916721 /Source="Nicolas_upshifts" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" CDS 916778..919348 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" /EC_number="2.3.2.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol lysyltransferase involved in tRNA-dependent lysinylation of phospholipids" /protein_id="YP_003097695.1" /db_xref="EnsemblGenomes-Gn:BSU08425" /db_xref="EnsemblGenomes-Tr:CAX52582" /db_xref="GOA:C0H3X7" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022791" /db_xref="InterPro:IPR024320" /db_xref="UniProtKB/Swiss-Prot:C0H3X7" /translation="MLIKKNALSILKIVFPIAVLLFVIYQSKKELTNLSFKRTLMVIN GLERTDLFMLVLIGLLAVAAMSLYDYVLKYSLRLSITNGKVFRVSWIANSFNNVLGFG GLAGVGLRMMFYKEHTKDHKALVKGIAWLTSSMLLGLSVFSIFVAARVLPVDEVIHEK PWLWAVVIGFALILPLSLAVSKIKDRKAGDEENADKVKNPIFAYIGASVVEWLMAGTV IYFALFAMGIHADIRYVFGVFVIAAIGGMISLVPGGFGSFDLLFLLGMEQLGYHQEAI VTSIVLYRLAYSFIPFILGLFFAAGDLTENTMKRLETNPRIAPAIETTNVLLVVQRAV LVRILQGSLSLIVFVAGLIVLASVSLPIDRLTVIPHIPRPALLLFNGLSLSSALILLI LPIELYKRTKRSYTMAITALVGGFVFSFLKGLNISAIFVLPMIIVLLVLLKKQFVREQ ASYTLGQLIFAVALFTVALFNYNLIAGFIWDRMKKVLRHEYFVHSTSHITHATIMAII IVPLFFLIFTVVYHKRTKPIGEKADPERLAAFLNEKGGNALSHLGFLGDKRFYFSSDG NALLLFGKIARRLVVLGDPSGQRESFPLVLEEFLNEAHQKGFSVLFYQIEREDMALYH DFGYNFFKLGEEAYVDLNTFTLTGKKKAGLRAINNRFEREEYTFHVDHPPFSDAFLEE LKQISDEWLGSKKEKGFSLGFFDPSYLQKAPIAYMKNAEGEIVAFANVMPMYQEGEIS VDLMRYRGDAPNGIMDALFIRMFLWAKEEGCTSFNMGMAPLANVGTAFTSFWSERFAA VIFNNVRYMYSFSGLRAFKEKYKPEWRGKYLAYRKNRSLSVTMFLVTRLIGKSKKDSV *" gene 916778..919348 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" downshifts 919319 /Source="Nicolas_upshifts" /id="D419" /incds=0 /nref=121 /ntot=252 /MaxReadThrough="1.79352" /MaxDrop="5.78159" /score="49.2396824" /energy="-16.1" /TU="NA" /idTUdmin="U641" /TUdmin=0 /isTUend="TRUE" CDS complement(919366..920343) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12354229, 19254027, 24606332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter binding lipoprotein" /protein_id="NP_388725.1" /db_xref="EnsemblGenomes-Gn:BSU08440" /db_xref="EnsemblGenomes-Tr:CAB12673" /db_xref="GOA:O31567" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12901" /db_xref="UniProtKB/Swiss-Prot:O31567" /translation="MKKHISMLFVFLMAVMVLSACNSSESSSNSEVSSSKTRTVKHAM GTSDNIPANPKRIVVLTNEGTEALLALGIKPVGAVKSWKGDPWYDYLKDDMKGVKNVG LETEPNVEAIAELKPDLIIGNKVRQEKIYDQLNAIAPTVFAESLAGNWKDNLTLYANA VNKADKGKEVIADFDKRVSDLKNKLGDQTNKTVSVVRFLSGESRIYYTDSFPGIILDQ LGFKRPEKQVELFKKQKDQFTFSTDSKESIPDMDADVLFYFTYKADNAKENEKWANQW TSSSLWKNLKAVKSGNAHEVDDVVWTTAGGIKAANYLLDDIETYFLKTK*" gene complement(919366..920343) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" downshifts complement(919377) /Source="Nicolas_upshifts" /id="D420" /incds=0 /nref=165 /ntot=248 /MaxReadThrough="1.28876" /MaxDrop="7.70135" /score="35.2605181" /energy="-16.1" /TU="NA" /idTUdmin="U643" /TUdmin="-4" /isTUend="TRUE" promotor_-35 920358..920365 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(920370..920389) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 920380..920399 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 920382..920473 /Source="Nicolas_S_feature" /locus_tag="new_920382_920473" /HighExp="dia0, Lbexp, LBGexp, H2O2, G150, GM 10, Oxctl, dia15, Paraq, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S287" upshifts 920382 /Source="Nicolas_upshifts" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" upshifts complement(920387) /Source="Nicolas_upshifts" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" promotor_-35 complement(920404..920411) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-35" CDS 920474..921475 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388726.1" /db_xref="EnsemblGenomes-Gn:BSU08450" /db_xref="EnsemblGenomes-Tr:CAB12674" /db_xref="GOA:O31568" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12902" /db_xref="UniProtKB/Swiss-Prot:O31568" /translation="MICKKASSKWIVLVCLIFILLTAVCASVVYGYTGTSWRQVYQAF TSFNGTNEHVIIKDVRLPRALVATVVGASLAAAGALMQALTKNPLASPGIFGINAGAG FFIVAGSFFLHIQSPQALVWSSFLGAAFTAAIVYAAGSLGREGLTPIKLTLAGAAMAA MFSSLTQGLLSVNELELAQVLFWLTGSVQGRSLDLLMTMFPYAAAALVICFFLGQKIN LLVMGEDVAKGLGQKTGLLKFVMALCVVMLAGSAVAIAGPISFIGIIIPHFARFVVGN DYRWVLPFSAVLGAILLVCADIGARYIIMPQEVPVGVMTAIIGMPVFVYIARRGAKL* " gene 920474..921475 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" CDS 921472..922503 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388727.1" /db_xref="EnsemblGenomes-Gn:BSU08460" /db_xref="EnsemblGenomes-Tr:CAB12675" /db_xref="GOA:O31569" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12876" /db_xref="UniProtKB/Swiss-Prot:O31569" /translation="MKLRFGVTAAEKKAWIVFLVLLGLTAAVLIISAGLGQRFIPPWD VAKTFFGAGSKLDELMIMSFRMPRILTALCAGVCLAAAGAILQGLVRNPLASPDIIGI TGGAAVAVVLLMMFFSDRSSSLTISLSWLPAAAFIGASAVGLIVYLLAYKNGASTFRL VLIGIGFSMSAQAMTTLLMIKGPIYRASQANVYITGSVYGSNWQHVKIAIILSVILLF ICFVALKNMNIQVLGEDIAAGAGSAVQRNRFFLLLLSTALTGCAVSVAGTIGFVGLMA PHIARRLVGSSYGALLPASALIGALLVLTADIVGRTLFAPVEVPAGVFTAAIGAPYFI YLLYKTRNS*" gene 921472..922503 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" downshifts 922484 /Source="Nicolas_upshifts" /id="D421" /incds=0 /nref=24 /ntot=154 /MaxReadThrough="3.26686" /MaxDrop="4.27732" /score="19.6751667" /energy="-12.8" /TU="NA" /idTUdmin="U642" /TUdmin="-3" /isTUend="TRUE" promotor_-35 922554..922556 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 922572..922591 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 922575 /Source="Nicolas_upshifts" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" CDS 922618..923499 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" /EC_number="5.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative isomerase" /protein_id="NP_388728.1" /db_xref="EnsemblGenomes-Gn:BSU08470" /db_xref="EnsemblGenomes-Tr:CAB12676" /db_xref="GOA:O31570" /db_xref="InterPro:IPR003719" /db_xref="SubtiList:BG12877" /db_xref="UniProtKB/Swiss-Prot:O31570" /translation="MKEAEVLKYEAFTSSPGKGNPAGVVLQGDDYTEDEMQIIAERAG YSETSFIRKSESADLELRYFTPGHEMNLCGHATVASLYALCEKGMLESGKTYSIQTKA GILPVKISEKDGRIHITLEQASPQFKPFTGDRKKLADALGITDEDFHEDLPIVFGSTG IWTAIVPLKSLEASKKMVPDNKQFPEVLVDLPKASVHPFTFETVHPDSDLHGRHFSSP YSGTIEDPVTGTASGVMGAYMKHYGNAEQHKFIIEQGQEIGKDGKVEIEMNEAGGHVK VNMTGTAVYSETRILKI*" gene 922618..923499 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" promotor_-35 923510..923517 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 923533..923552 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 923542 /Source="Nicolas_upshifts" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" CDS 923587..924171 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" /EC_number="1.6.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 22287527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (nitroreductase family)" /protein_id="NP_388729.1" /db_xref="EnsemblGenomes-Gn:BSU08480" /db_xref="EnsemblGenomes-Tr:CAB12677" /db_xref="GOA:O31571" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR026021" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG12878" /db_xref="UniProtKB/Swiss-Prot:O31571" /translation="MPQTEQIHQHSVLRDIIRSRRSIRKFKQEPVPSAVILDMLETAK YAPNHRVTEPWRFIYVSSETGKANLINTFAAFSKKSKPDMTEEKLQNFKNTLGRVPGF LLVVFQEDENERARDDDFAATSSLIQNLQLLAWEKGIGMVWKSGKILYDKEVHQAFGL QDNERFAAIIQTGYPDEAPEVKKRTPIRDRFTEM*" gene 923587..924171 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" downshifts 924158 /Source="Nicolas_upshifts" /id="D422" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="3.27483" /MaxDrop="6.40857" /score="21.7703837" /energy="-18.2" /TU="U645" /idTUdmin="U644" /TUdmin="-1" /isTUend="TRUE" CDS complement(924210..924401) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388730.1" /db_xref="EnsemblGenomes-Gn:BSU08490" /db_xref="EnsemblGenomes-Tr:CAB12678" /db_xref="InterPro:IPR025435" /db_xref="SubtiList:BG12879" /db_xref="UniProtKB/Swiss-Prot:O31572" /translation="MGRNHIHKNRDKNKQKLPQVPDALKRETDGVYEEYSTELADADD REAQERAKAADNRAKKKSR*" gene complement(924210..924401) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" downshifts complement(924228) /Source="Nicolas_upshifts" /id="D423" /incds=0 /nref=65 /ntot=197 /MaxReadThrough="0.436919999999999" /MaxDrop="8.51174" /score="30.1998663" /energy="-18.2" /TU="NA" /idTUdmin="U649" /TUdmin=7 /isTUend="TRUE" upshifts complement(924433) /Source="Nicolas_upshifts" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" promotor_-10 complement(924436..924447) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(924462..924468) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(924468..924578) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388731.1" /db_xref="EnsemblGenomes-Gn:BSU08500" /db_xref="EnsemblGenomes-Tr:CAB12679" /db_xref="InterPro:IPR025437" /db_xref="SubtiList:BG12880" /db_xref="UniProtKB/Swiss-Prot:O31573" /translation="MEKKREKHQQGANLKKMQEVLYSGEFKKAEKAAKRK*" gene complement(924468..924578) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" promotor_-10 complement(924607..924618) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(924609) /Source="Nicolas_upshifts" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" promotor_-35 complement(924633..924639) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(924633..925544) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotide-or NAD-binding protein" /protein_id="NP_388732.1" /db_xref="EnsemblGenomes-Gn:BSU08510" /db_xref="EnsemblGenomes-Tr:CAB12680" /db_xref="GOA:O31574" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR010099" /db_xref="InterPro:IPR013549" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12881" /db_xref="UniProtKB/Swiss-Prot:O31574" /translation="MNIAMTGGTGFLGQHLTGVLTRQGHHVYILSRNARETEQKNMTY VQWLSEGAAPEQELPHIDVWINLAGKSIFGRWTEKTKQHILSSRINATREVQRLIQKQ KEKPKTLIQASAVGIYGTSLEKTFTEDSATSDEDFLSHTAHLWEKEGQHIEAMGIRTV YARFGVMLGEKGALPLMILPYKFLAGGTIGTGRQWLSWIHVEDAAQMIRYAVENAGIS GPMNVTAPNPVDMKQFGKTIARVKHRPHWLPVPEFFLSKALGEMSLLIVKGQRALPKK AITSGFRFTYSDLEFALSQLIADRKTV*" gene complement(924633..925544) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" promotor_-35 925430..925433 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 925450..925469 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 925460..925632 /Source="Nicolas_S_feature" /locus_tag="new_925460_925632" /HighExp="LBGstat, Lbtran, T1.30H, T2.0H, T2.30H, M9-stat, T1.0H, T3.0H, Sw, G180" /AntisenseName="yfhF" /AntisenseCor="-5.3501479327985699E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S288" upshifts 925460 /Source="Nicolas_upshifts" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" promotor_-10 complement(925566..925584) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(925580) /Source="Nicolas_upshifts" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" promotor_-35 complement(925598..925604) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 925633..926427 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" /function="16.3: Control" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8946165, 10869079, 12547390, 23284295, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8946165, 10869079, 12547390, 23284295, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulatory protein RecX" /protein_id="NP_388733.1" /db_xref="EnsemblGenomes-Gn:BSU08520" /db_xref="EnsemblGenomes-Tr:CAB12681" /db_xref="GOA:O31575" /db_xref="InterPro:IPR003783" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12882" /db_xref="UniProtKB/Swiss-Prot:O31575" /translation="MPFITKISTQKKNTERFNIFLDDKYAFSVDADVLVKFELKKGKE LDDLDIIEIQYGDEVKKGFNRALDFLSYRMRSTKEVEDHLKKKETSPPVIAEVIHRLN DYKYLNDQEFAAAYVSTHKKTNGKGPDVLFRELRAKGIDDDTIKEALSSFSFEDQTRE AVKHVEKLLKKDKKLSTKELKQRAQLQLQRKGFSFDVISAAMDQIEYENDEDTEKEAL RLHAEKAFRKYRYDGSYESAMKVKQFLFRKGFSLDLIEQLLQEEEY*" gene 925633..926427 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" CDS 926429..926743 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388734.1" /db_xref="EnsemblGenomes-Gn:BSU08530" /db_xref="EnsemblGenomes-Tr:CAB12682" /db_xref="InterPro:IPR014938" /db_xref="InterPro:IPR036289" /db_xref="PDB:1SF9" /db_xref="SubtiList:BG12883" /db_xref="UniProtKB/Swiss-Prot:O31576" /translation="MEKRYSQMTPHELNTEIALLSEKARKAEQHGIINELAVLERKIT MAKAYLLNPEDYSPGETYRVENTEDEFTISYLNGVFAWGYRTSSPQQEEALPISVLQE KE*" gene 926429..926743 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" S_feature complement(926651..926919) /Source="Nicolas_S_feature" /locus_tag="new_926651_926919_c" /HighExp="S8, S6, S5, S7, C30, S4, nit, ferm, BT, G135" /AntisenseName="yfhH" /AntisenseCor="-0.53569713251514905" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S289" downshifts 926733 /Source="Nicolas_upshifts" /id="D424" /incds=0 /nref=71 /ntot=206 /MaxReadThrough="2.93348" /MaxDrop="5.2859" /score="24.7235138" /energy="-11.6" /TU="NA" /idTUdmin="U648" /TUdmin=0 /isTUend="TRUE" promotor_-35 926817..926822 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 926838..926857 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 926843 /Source="Nicolas_upshifts" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" CDS 926886..928079 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388735.1" /db_xref="EnsemblGenomes-Gn:BSU08540" /db_xref="EnsemblGenomes-Tr:CAB12683" /db_xref="GOA:O31577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12884" /db_xref="UniProtKB/Swiss-Prot:O31577" /translation="MSIKNPSVKFIIFVLMICTFSIGYTEYAVMGILTSIANDFHIQV SSAGLLVTAYAASVCLTGPLVTIISVKLPRKPVLLGLMAIFILSNLMSALAPNFAVLA ISRILSASIHGAFFAIAMVFASEMVPPEKRAAAAASMNGGLTVALMLGVPFGSYLGDV LNWRAVFSIITALGVIGFLGLMAAVPNRKPKVIPMLMNEWGVFKHKQVLFSFAITILG YSGVFIAYTFIEPILRHSAGFSTVGITGALFAYGLGGVAGNFFAGKVPLPLLTRTMIG VMIGLIGVLAVFPYIAIYPAAAIVATFLFGACAFGTPPLLQTKVISSSEGGTTIAAAV SVSAFNLANALGAWIGGMILNGTGSYSWLFAGGALMTACGLVLSTFAHLSEKKSVYEY QVNKG*" gene 926886..928079 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" S_feature 928080..928314 /Source="Nicolas_S_feature" /locus_tag="new_928080_928314" /HighExp="G180, Paraq, C30, Oxctl, H2O2, G135, G150, S8, Heat, LBGstat" /AntisenseName="sspK" /AntisenseCor="1.9886505145521101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S290" CDS complement(928112..928264) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054573.1" /db_xref="EnsemblGenomes-Gn:BSU08550" /db_xref="EnsemblGenomes-Tr:CAE01449" /db_xref="GOA:Q7WY75" /db_xref="InterPro:IPR012611" /db_xref="SubtiList:BG14175" /db_xref="UniProtKB/Swiss-Prot:Q7WY75" /translation="MVRNKEKGFPYENENKFQGEPRAKDDYASKRADGSINQHPQERM RASGKR*" gene complement(928112..928264) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" downshifts complement(928129) /Source="Nicolas_upshifts" /id="D425" /incds=0 /nref=24 /ntot=45 /MaxReadThrough="2.36419" /MaxDrop="4.9889" /score="20.2715496" /energy="-12.3" /TU="NA" /idTUdmin="U652" /TUdmin=0 /isTUend="TRUE" promotor_-35 928293..928300 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 928314..928333 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 928316..928388 /Source="Nicolas_S_feature" /locus_tag="new_928316_928388" /HighExp="dia5, LPhT, Diami, dia15, Etha, T0.30H, H2O2, LBGstat, BC, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S291" upshifts 928316 /Source="Nicolas_upshifts" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" promotor_-10 complement(928323..928334) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(928333) /Source="Nicolas_upshifts" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" promotor_-35 complement(928349..928355) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 928389..928658 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388736.1" /db_xref="EnsemblGenomes-Gn:BSU08560" /db_xref="EnsemblGenomes-Tr:CAB12684" /db_xref="InterPro:IPR026952" /db_xref="SubtiList:BG12885" /db_xref="UniProtKB/Swiss-Prot:O31578" /translation="MNMYIEKLTNLLLEKNEMISYIQAKTWVELLWSDFEATYAKAGH AYQGEKMTEKIVTQWIENYGGQLHLFQSSRNDVNDYLNQSRGLLH*" gene 928389..928658 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" downshifts 928647 /Source="Nicolas_upshifts" /id="D426" /incds=0 /nref=62 /ntot=233 /MaxReadThrough="2.9538" /MaxDrop="5.3621" /score="19.3423239" /energy="-10.6" /TU="NA" /idTUdmin="U650" /TUdmin=0 /isTUend="TRUE" promotor_-35 928736..928742 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 928757 /Source="Nicolas_upshifts" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" promotor_-10 928758..928776 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 928803..929321 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388737.1" /db_xref="EnsemblGenomes-Gn:BSU08570" /db_xref="EnsemblGenomes-Tr:CAB12685" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12886" /db_xref="UniProtKB/Swiss-Prot:O31579" /translation="MKKKQVMLALTAAAGLGLTALHSAPAAKAAPLHDISVSMPSSDT YIIKAGKLNVRTEPNHEGDILGTVSSEQKVKVDRFVNADWAQIHFKGKKAYISTHFLM KTASQAKTTKQTAFYTPTPENGKAKQLSSGTEVTILGWGFSENGGFDFTWAFVDYGGV KGYIHTKDLQMR*" gene 928803..929321 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" S_feature 929322..929389 /Source="Nicolas_S_feature" /locus_tag="new_929322_929389" /HighExp="Etha, Sw, Salt, M9-stat, B60, B36, Gly, LoTm, BC, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S292" promotor_-35 929357..929366 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-35" promotor_-10 929378..929393 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-10" upshifts 929391 /Source="Nicolas_upshifts" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" CDS 929406..929738 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor for peptide SdpC immunity" /protein_id="NP_388738.1" /db_xref="EnsemblGenomes-Gn:BSU08580" /db_xref="EnsemblGenomes-Tr:CAB12686" /db_xref="GOA:O31580" /db_xref="InterPro:IPR025962" /db_xref="SubtiList:BG12887" /db_xref="UniProtKB/Swiss-Prot:O31580" /translation="MTGLVGGGLMIIAGILIKLFPPKSINSVYGYRTRRSMSDQRLWN EANRYSASLMILSGLVIAGMGLLLGSNLFILQLILLIAACVITFMLTEKRLKIMTHSQ GGDRSGRS*" gene 929406..929738 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" CDS 929725..930585 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" /EC_number="3.3.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16597997, 20941576" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16597997, 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stress induced epoxide hydrolase" /protein_id="NP_388739.1" /db_xref="EnsemblGenomes-Gn:BSU08590" /db_xref="EnsemblGenomes-Tr:CAB12687" /db_xref="GOA:O31581" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12888" /db_xref="UniProtKB/Swiss-Prot:O31581" /translation="MDGVKCQFVNTNGITLHVAAAGREDGPLIVLLHGFPEFWYGWKN QIKPLVDAGYRVIAPDQRGYNLSDKPEGIDSYRIDTLRDDIIGLITQFTDEKAIVIGH DWGGAVAWHLASTRPEYLEKLIAINIPHPHVMKTVTPLYPPQWLKSSYIAYFQLPDIP EASLRENDYDTLDKAIGLSDRPALFTSEDVSRYKEAWKQPGALTAMLNWYRALRKGSL AEKPSYETVPYRMIWGMEDRFLSRKLAKETERHCPNGHLIFVDEASHWINHEKPAIVN QLILEYLKNQ*" gene 929725..930585 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" downshifts 930583 /Source="Nicolas_upshifts" /id="D427" /incds=0 /nref=27 /ntot=191 /MaxReadThrough="5.0793" /MaxDrop="4.1326" /score="3.7712168" /energy="-8.4" /TU="U653,U654" /idTUdmin="U654" /TUdmin="-132" /isTUend="FALSE" promotor_-35 930643..930649 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 930663..930674 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 930671..930735 /Source="Nicolas_S_feature" /locus_tag="new_930671_930735" /HighExp="Etha, S5, M9-stat, T0.30H, Sw, T-0.40H, B60, S8, B36, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S293" upshifts 930671 /Source="Nicolas_upshifts" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" promotor_-10 complement(930693..930712) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(930702) /Source="Nicolas_upshifts" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 930718..930724 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(930726..930727) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 930737..930817 /Source="Nicolas_S_feature" /locus_tag="new_930737_930817" /HighExp="M9-stat, LBGexp, Lbexp, T0.30H, dia0, T1.30H, T1.0H, LBGtran, Paraq, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF, SigB" /TUshortPSig="1, 0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S294" upshifts 930737 /Source="Nicolas_upshifts" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" promotor_-10 930739..930757 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 930818..931807 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" /EC_number="2.4.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8921856, 9636707, 23632331; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bactoprenol glycosyl transferase, phageorigin" /protein_id="NP_388740.1" /db_xref="EnsemblGenomes-Gn:BSU08600" /db_xref="EnsemblGenomes-Tr:CAB12688" /db_xref="GOA:Q45539" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11834" /db_xref="UniProtKB/Swiss-Prot:Q45539" /translation="MKQGLISIIIPSYNEGYNVKLIHESLKKEFKNIHYDYEIFFIND GSVDDTLQQIKDLAATCSRVKYISFSRNFGKEAAILAGFEHVQGEAVIVMDADLQHPT YLLKEFIKGYEEGYDQVIAQRNRKGDSFVRSLLSSMYYKFINKAVEVDLRDGVGDFRL LSRQAVNALLKLSEGNRFSKGLFCWIGFDQKIVFYENVERKNGTSKWSFSSLFNYGMD GVVSFNHKPLRLCFYTGIFILLLSIIYIIATFVKILTNGISVPGYFTIISAVLFLGGV QLLSLGIIGEYIGRIYYETKKRPHYLIKEANIPNKDLPETNELKSMRRLTKMH*" gene 930818..931807 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" upshifts complement(930967) /Source="Nicolas_upshifts" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(930972..930976) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(930993..930997) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 931808..931878 /Source="Nicolas_S_feature" /locus_tag="new_931808_931878" /HighExp="LPhT, Heat, Etha, LBGexp, M9-stat, LBGtran, Lbexp, Sw, dia0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigB" /TUshortPSig="1, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S295" CDS 931879..934464 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23632331; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388741.2" /db_xref="EnsemblGenomes-Gn:BSU08610" /db_xref="EnsemblGenomes-Tr:CAB12689" /db_xref="GOA:O31582" /db_xref="InterPro:IPR018580" /db_xref="SubtiList:BG12889" /db_xref="UniProtKB/Swiss-Prot:O31582" /translation="MKRKHIMIYAASLLVSVLAHAFFVKEWAEGRYMTGPGDGLAQMI VFKKLLFDQYTHGNFFYNYSFGLGGGTFSQLGYYFSASFLFLAVSAAVWLLQAVQLIG ETDTLFWAESAVFISIFKLSLIIFTSASVFHYLLKHRAASFTGAVLYGVSIIYFRHEA YWEFFTDTMVWLPLLVLGAEKIIRERRPAWFIVACSLTLINNFYFAYINLIFIGIYVL FRWLIRLEPHEEKRWIQIRLFLVSGFISFGISAAAFVPVVYGFLNNLRPPYSQKIEWL NFDDNILFSSRIIIVPAAFLLFLFIISFYKNRVFRLFAGLSLLFILFHFSPYAASVFN GFSAPQNRFEYVLAFTIAGAAAAGLSQLSELKRKELLPAAAVVLLLYLYHIQRYKLDI WKPANESILLLLLMTIAALFAAAFAKKRAKMAVYGIIILSSLFVANSYQKYALSEGGD LDSVTKEYLTSEEYRGRESSELIRRLQKEDDDPLMRIDWMNGVRNNTPIIYGFNGFSA YSSILNKDLLAFYWNDLSIDMGRESVSRYASLGDRANLYSLLYGKYYMTEKTNEASVP YGFKKHLETEHYAVYENQYMLPFVKTADAIYSESELDRLPALAKEQAMLKGIILKDPS GKTEQTPKPSNLITKSDITAKQAQYQNGLLTVTGENGGELIITPKQPSSAPGDYYVSF YLKSKAKDKGFTLKVNDYVTTRKSNKSIYKTGVNNITVRVPKSGHISINLPKGTYELR NIALYEENYQTLKNAVMQNKTEKADKLNWNKNRLTFSYHLSKDQYIMLPIPYEKGWEL KINGKTQKIEKADYAFIGFKAQKGDNHIELTYYPPYFKISAIISLVSLLLAVFYIRRK KPGSI*" gene 931879..934464 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" downshifts 934433 /Source="Nicolas_upshifts" /id="D428" /incds=0 /nref=63 /ntot=217 /MaxReadThrough="2.13267" /MaxDrop="4.17784" /score="2.41489488" /energy="-13.3" /TU="NA" /idTUdmin="U657" /TUdmin="-1" /isTUend="TRUE" CDS complement(934457..935440) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10463184, 10524235, 15849754, 16850406, 24237659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_388742.1" /db_xref="EnsemblGenomes-Gn:BSU08620" /db_xref="EnsemblGenomes-Tr:CAB12690" /db_xref="GOA:O31583" /db_xref="InterPro:IPR007404" /db_xref="SubtiList:BG12890" /db_xref="UniProtKB/Swiss-Prot:O31583" /translation="MDTGTHVVMGIALGGIATLDPVVGSDPAMAHAVMIATLAGSQAP DIDTVLKLKNNAVYIRNHRGFTHSIPAVLFWSVIIPAILYLFYPQADFLHLWLWTLLA VVLHVFVDIFNAYGTQAIRPFSKKWVALGLINTFDPFIFISHLAAIAIWYAGGSPGIT FLSLYIILVGYYLVRLIMQLRIKRKLHEMIHDEIESIIISPTMKFRQWRIAVTTAHAF YVGRSMEGHVVILDTFNRVPVPETDVMHAAKQDDNIAAFLSFSPVYRWEVDTFKDHYE VRFIDLRYRSKGHYPFVAIVHIGHDLTIRSSYTGWIFSEEKLQKKLKLGSI*" gene complement(934457..935440) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" downshifts complement(934491) /Source="Nicolas_upshifts" /id="D429" /incds=0 /nref=28 /ntot=200 /MaxReadThrough="2.65266" /MaxDrop="4.43244" /score="25.5564412" /energy="-17.5" /TU="NA" /idTUdmin="U661" /TUdmin="-3" /isTUend="TRUE" promotor_-35 934914..934923 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 934936..934955 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 934940 /Source="Nicolas_upshifts" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(935441..935588) /Source="Nicolas_S_feature" /locus_tag="new_935441_935588_c" /HighExp="Diami, dia15, M9-stat, dia5, Etha, H2O2, S6, Salt, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S296" promotor_-35 935545..935549 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 935565..935584 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 935572 /Source="Nicolas_upshifts" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" S_feature 935578..935655 /Source="Nicolas_S_feature" /locus_tag="new_935578_935655" /HighExp="H2O2, G150, G180, LBGstat, dia15, Diami, Oxctl, Paraq, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S297" promotor_-10 complement(935586..935605) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(935588) /Source="Nicolas_upshifts" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" promotor_-35 complement(935620..935627) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 935656..936765 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" /EC_number="3.2.2.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10463184, 20971907, 21954439, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10463184, 20971907, 21954439, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="A/G-specific adenine glycosylase or DNA-(apurinic or apyrimidinic site) lyase" /protein_id="NP_388743.1" /db_xref="EnsemblGenomes-Gn:BSU08630" /db_xref="EnsemblGenomes-Tr:CAB12691" /db_xref="GOA:O31584" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR005760" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR029119" /db_xref="SubtiList:BG12891" /db_xref="UniProtKB/Swiss-Prot:O31584" /translation="MNVLEDKLKQKDIQQFRDDLISWFEREQRVLPWREDQDPYKVWV SEVMLQQTRVETVIPYFLRFVEQFPTVEALADADEEKVLKAWEGLGYYSRVRNLQSAV KEVKQEYGGIVPPDEKDFGGLKGVGPYTKGAVLSIAYNKPIPAVDGNVMRVMSRILSI WDDIAKPKTRTIFEDAIRAFISKEKPSEFNQGLMELGALICTPKSPSCLLCPVQQHCS AFEEGTERELPVKSKKKKPGIKTMAAIVLTDEDGQVYIHKRPSKGLLANLWEFPNLET QKGIKTEREQLIAFLENEYGIQADISDLQGVVEHVFTHLVWNISVFFGKVKQVSDTSK LKKVTKEELEQFAFPVSHQKIWKMAGEAAAISAAP*" gene 935656..936765 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" promotor_-35 936602..936606 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 936622..936641 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 936634 /Source="Nicolas_upshifts" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" S_feature 936766..937078 /Source="Nicolas_S_feature" /locus_tag="new_936766_937078" /HighExp="H2O2, G150, dia15, G135, G180, Oxctl, Paraq, dia0, LBGexp, Lbexp" /AntisenseName="yfhS" /AntisenseCor="-0.72611377663365595" /AntisenseRegPval="-44.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S298" CDS complement(936773..936997) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10463184" /codon_start=1 /transl_table=11 /product="conserved protein related to sporulation" /protein_id="NP_388744.1" /db_xref="EnsemblGenomes-Gn:BSU08640" /db_xref="EnsemblGenomes-Tr:CAB12692" /db_xref="SubtiList:BG12892" /db_xref="UniProtKB/Swiss-Prot:O31585" /translation="MYVGRDMSELNMVSKKDWKNSELAYFHHAFQQIMPYLNEEGQSK YRELTQEIEARGGMKRNEADYSHGTRVSYD*" gene complement(936773..936997) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" promotor_-10 complement(937027..937038) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(937029) /Source="Nicolas_upshifts" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" promotor_-35 complement(937052..937058) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 937079..937831 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" /EC_number="1.3.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 12440970, 17329825, 21185310" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 12440970, 17329825, 21185310; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase III" /protein_id="NP_388745.1" /db_xref="EnsemblGenomes-Gn:BSU08650" /db_xref="EnsemblGenomes-Tr:CAB12693" /db_xref="GOA:P71079" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIC" /db_xref="PDB:3OID" /db_xref="SubtiList:BG12221" /db_xref="UniProtKB/Swiss-Prot:P71079" /translation="MEQNKCALVTGSSRGVGKAAAIRLAENGYNIVINYARSKKAALE TAEEIEKLGVKVLVVKANVGQPAKIKEMFQQIDETFGRLDVFVNNAASGVLRPVMELE ETHWDWTMNINAKALLFCAQEAAKLMEKNGGGHIVSISSLGSIRYLENYTTVGVSKAA LEALTRYLAVELSPKQIIVNAVSGGAIDTDALKHFPNREDLLEDARQNTPAGRMVEIK DMVDTVEFLVSSKADMIRGQTIIVDGGRSLLV*" gene 937079..937831 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" promotor_-35 937848..937854 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 937869..937880 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 937870 /Source="Nicolas_upshifts" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" promotor_-10 complement(937877..937891) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(937898) /Source="Nicolas_upshifts" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(937900..937904) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 937900..938154 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1744043, 7592342, 9540829, 19542328, 23314362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744043, 7592342, 9540829, 19542328, 23314362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (gamma-type SASP)" /protein_id="NP_388746.1" /db_xref="EnsemblGenomes-Gn:BSU08660" /db_xref="EnsemblGenomes-Tr:CAB12694" /db_xref="GOA:P07784" /db_xref="InterPro:IPR006341" /db_xref="SubtiList:BG10789" /db_xref="UniProtKB/Swiss-Prot:P07784" /translation="MANSNNFSKTNAQQVRKQNQQSAAGQGQFGTEFASETNAQQVRK QNQQSAGQQGQFGTEFASETDAQQVRQQNQSAEQNKQQNS*" gene 937900..938154 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" downshifts 938152 /Source="Nicolas_upshifts" /id="D430" /incds=0 /nref=261 /ntot=269 /MaxReadThrough="1.59207" /MaxDrop="8.74804" /score="9.25353719" /energy="-9.5" /TU="NA" /idTUdmin="U660" /TUdmin=0 /isTUend="TRUE" downshifts complement(938177) /Source="Nicolas_upshifts" /id="D431" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.21036" /MaxDrop="5.14076" /score="-9.78320441" /energy="-7.1" /TU="NA" /idTUdmin="U663" /TUdmin="-1687" /isTUend="FALSE" CDS 938243..938587 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388747.1" /db_xref="EnsemblGenomes-Gn:BSU08670" /db_xref="EnsemblGenomes-Tr:CAB12695" /db_xref="InterPro:IPR025572" /db_xref="SubtiList:BG12222" /db_xref="UniProtKB/Swiss-Prot:P71080" /translation="MSQRVCFMEIEMIKGGNVYTFIRLKEEPMTEFEKLVSEQMKTMD KLLDLQSELDRCKQIEAELRHLERDARLRGIQAEIAVKRKHLADIQDMFQKQTEQVIR SYRSSEKPSSFV*" gene 938243..938587 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" promotor_-35 938250..938258 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 938269..938287 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 938271 /Source="Nicolas_upshifts" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" downshifts 938570 /Source="Nicolas_upshifts" /id="D432" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.84572" /MaxDrop="3.29993" /score="13.9694142" /energy="-11.5" /TU="U666" /idTUdmin="U660" /TUdmin=418 /isTUend="FALSE" promotor_-35 938626..938633 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 938647..938666 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 938656..938730 /Source="Nicolas_S_feature" /locus_tag="new_938656_938730" /HighExp="Etha, dia15, dia5, Diami, Salt, H2O2, BC, T5.0H, Cold, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S299" upshifts 938656 /Source="Nicolas_upshifts" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" CDS 938731..939261 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19383706, 22333191; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding factor" /protein_id="NP_388748.3" /db_xref="EnsemblGenomes-Gn:BSU08680" /db_xref="EnsemblGenomes-Tr:CAB12696" /db_xref="InterPro:IPR007295" /db_xref="InterPro:IPR016882" /db_xref="InterPro:IPR035930" /db_xref="SubtiList:BG12223" /db_xref="UniProtKB/Swiss-Prot:Q796Z1" /translation="MGYPKEGETIQIHSYKHNGLIHRIWNETTILKSTEMCVIGANDR TMVTESDGRTWITREPAICYFHARQWFNVIGMLREDGVHYYCNISSPFAYDGEAIKYI DYDLDVKVFPDMTYNILDEDEYDDHRKAMNYPKEIDSILRDYLNTLLHWIHQRQGPFA PEFVDMWYERYLRYTK*" gene 938731..939261 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" downshifts 939252 /Source="Nicolas_upshifts" /id="D433" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="6.10669" /MaxDrop="3.97335" /score="-5.22328881" /energy="-7" /TU="U667" /idTUdmin="U666" /TUdmin=0 /isTUend="TRUE" CDS 939349..941091 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388749.2" /db_xref="EnsemblGenomes-Gn:BSU08690" /db_xref="EnsemblGenomes-Tr:CAB12697" /db_xref="GOA:P71082" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12224" /db_xref="UniProtKB/Swiss-Prot:P71082" /translation="MGVMKRYMQFVKPYKKQIFVTVLIGIVKFSIPLALPLLLKYVVD DIIQGGGTASDKTTSLFTIMAIMFALFLILRPPVEYYRQYFAQWTASKVLYDIRAKLF DHIQKLSLRFYANTRTGEVISRVINDVEQTKDFVITGLMNIWLDMLTILIVISIMLTL DVKLTLISIVLFPLYGISVKYFYGRLRKLTRERSQALAQVQGHLHERIQGMPVIRSFA IEDHEQAQFNEKNGHFLDKAIRHTNWNAKTFAVVNTITDLAPLIVIACAGYFVINGPL TVGTMVAFVGYIDRMYNPVRRLINSSTTLTQSIASMDRVFEFIDEPYELTDKPNAIKA DQIRGGVEFQNVSFQYEKDKENILHDVSLKVNRGETVALVGMSGGGKSTLVSLIPRFY DVTSGRLLIDGTDIRDYEARSLRNQVGMVLQDTFLFSETIRENIAIGKPDATLEEIIE AAKAANAHEFIMSFPEGYETRVGERGVKLSGGQKQRISIARVFLKNPPLLILDEATSA LDLESEHYIQEAMDKLAKDRTTFVVAHRLSTITHADKIVVMENGTIIEIGTHDELMDY ESQYKHLFTIQNLN*" gene 939349..941091 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" downshifts 941078 /Source="Nicolas_upshifts" /id="D434" /incds=0 /nref=87 /ntot=233 /MaxReadThrough="2.54676" /MaxDrop="5.20475" /score="22.3853226" /energy="-14.1" /TU="NA" /idTUdmin="U667" /TUdmin=0 /isTUend="TRUE" CDS complement(941168..942229) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388750.1" /db_xref="EnsemblGenomes-Gn:BSU08700" /db_xref="EnsemblGenomes-Tr:CAB12698" /db_xref="GOA:P71083" /db_xref="InterPro:IPR010343" /db_xref="SubtiList:BG12225" /db_xref="UniProtKB/Swiss-Prot:P71083" /translation="MKLGARIFKTGIAITLALYLASWIGLPAPIFAGIAAIFAIQPSI YRSFLIIIDQVQANIIGAVIATVFGLIFGPSPIMIGLTAVIVITIMLKLKIEHTISIA LVTVIAILESAGDDFLMFALIRTSTVILGVLSSFIVNLVFLPPKYETKLIHNTVENTE EIMKWIRLSMRQSTEHSILKEDIEKLKEKMIKLDQTYLLYKEERSYFKKTTYVKSRKL VLFRQAIITANRALDTLKKLHRLENEIYHMPEEFQETLTEELDYLLYWHERILMRFVG KIKPHDDAVEEGIRYKQLLTKSFLKNQQNTDEELIDYNMLNIMASAVEYREQLEHLET LITSFQTYHPKDCEIETEE*" gene complement(941168..942229) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" downshifts complement(941179) /Source="Nicolas_upshifts" /id="D435" /incds=0 /nref=181 /ntot=254 /MaxReadThrough="1.1413" /MaxDrop="7.13599" /score="26.0617552" /energy="-9.4" /TU="NA" /idTUdmin="U668" /TUdmin="-3" /isTUend="TRUE" S_feature complement(942230..942320) /Source="Nicolas_S_feature" /locus_tag="new_942230_942320_c" /HighExp="G180, Oxctl, Paraq, C30, G150, LBGexp, LPhT, S4, G135, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S300" promotor_-10 complement(942318..942337) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(942327) /Source="Nicolas_upshifts" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" promotor_-35 complement(942352..942359) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(942449..943738) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231799, 19930658; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde aminotransferase, classIII aminotransferase" /protein_id="NP_388751.3" /db_xref="EnsemblGenomes-Gn:BSU08710" /db_xref="EnsemblGenomes-Tr:CAB12699" /db_xref="GOA:P71084" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11943" /db_xref="UniProtKB/Swiss-Prot:P71084" /translation="MHTKSIELHNEALQHIVGGVNSPSRSYKAVGGGSPVAMEKASGA YFWDVDGNKYIDYLAAYGPIITGHAHPHITEAIKKAAENGVLYGTPTKHEVTFAKMLK EAIPAMDKVRFVNSGTEAVMTTIRVARAYTGRTKIIKFAGCYHGHSDLVLVAAGSGPS TLGTPDSAGVPKSIANEVITVPFNDIDSYKAALEKWGSEIAAVLVEPIVGNFGIVEPK EGFLEQVNELTHNAGALVIYDEVITAFRFMYGGAQDLLQVKPDLTALGKIIGGGLPIG AYGGKQEIMEQVAPLGPAYQAGTMAGNPASILSGIACLEVLKEKGVYEKLDHLGAMLE EGILKHAETHGITITVNRLKGALTVYFSDEKVENYEQAERSDGETFSTFFKLMLERGI NLAPSKYEAWFITTAHTEQDIKDTLTAVEDAFKHLKN*" gene complement(942449..943738) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" downshifts complement(942452) /Source="Nicolas_upshifts" /id="D436" /incds=0 /nref=235 /ntot=258 /MaxReadThrough="2.54961" /MaxDrop="5.8522" /score="29.5551149" /energy="-11" /TU="NA" /idTUdmin="U669" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(943766..943785) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(943785) /Source="Nicolas_upshifts" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" S_feature complement(943787..944498) /Source="Nicolas_S_feature" /locus_tag="new_943787_944498_c" /HighExp="LoTm, M9-stat, B60, S8, C30, Cold, B36, T1.30H, Etha, T2.0H" /AntisenseName="ygaF" /AntisenseCor="-0.29702219161000198" /AntisenseRegPval="-6.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S301" promotor_-35 complement(943797..943802) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 943831..943838 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 943852..943871 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 943852 /Source="Nicolas_upshifts" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" CDS 943891..944364 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" /EC_number="1.11.1.15" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10644761, 11349039, 12950915, 21910476, 26723255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin with versatile activity" /protein_id="YP_054574.1" /db_xref="EnsemblGenomes-Gn:BSU08720" /db_xref="EnsemblGenomes-Tr:CAB12700" /db_xref="GOA:Q796Y8" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12226" /db_xref="UniProtKB/Swiss-Prot:Q796Y8" /translation="MTIEIGQKAPDLELKGDHGETVKLSDYKGKYIVLYFYPKDMTPG CTTEACDFRDSHESFAELDAVIIGVSPDSQEKHGKFKEKHNLPFLLLVDDEHKLAEAF DVWKLKKNFGKEYMGIERSTFLIDKEGRLIKEWRKVKVKDHVAEALQTLKDMSEK*" gene 943891..944364 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" promotor_-35 944401..944408 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 944423..944442 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 944429 /Source="Nicolas_upshifts" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" CDS 944487..944924 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1580225, 16541078, 16925555, 22194458, 27935957, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1580225, 16541078, 16925555, 22194458, 27935957, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Fur family)" /protein_id="NP_388753.1" /db_xref="EnsemblGenomes-Gn:BSU08730" /db_xref="EnsemblGenomes-Tr:CAB12701" /db_xref="GOA:P71086" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FE3" /db_xref="PDB:2RGV" /db_xref="PDB:3F8N" /db_xref="SubtiList:BG12227" /db_xref="UniProtKB/Swiss-Prot:P71086" /translation="MAAHELKEALETLKETGVRITPQRHAILEYLVNSMAHPTADDIY KALEGKFPNMSVATVYNNLRVFRESGLVKELTYGDASSRFDFVTSDHYHAICENCGKI VDFHYPGLDEVEQLAAHVTGFKVSHHRLEIYGVCQECSKKENH*" gene 944487..944924 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" downshifts 944906 /Source="Nicolas_upshifts" /id="D437" /incds=0 /nref=149 /ntot=247 /MaxReadThrough="3.98479" /MaxDrop="7.52234" /score="1.62878623" /energy="-12.3" /TU="U670,U671" /idTUdmin="U670" /TUdmin="-66" /isTUend="FALSE" CDS complement(944959..945312) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_054575.1" /db_xref="EnsemblGenomes-Gn:BSU08740" /db_xref="EnsemblGenomes-Tr:CAE01450" /db_xref="GOA:Q7WY74" /db_xref="InterPro:IPR020912" /db_xref="SubtiList:BG14192" /db_xref="UniProtKB/Swiss-Prot:Q7WY74" /translation="MAKYSSKINKIRTFALSLVFVGFIIMYIGIFFKESVLLSSLFMI LGLLSIGLSTVVYFWIGMLSTKAVRVICPGCDKETKVLGVVDMCMHCREPLTLDKGLE GKEFDESYNKKKMSK*" gene complement(944959..945312) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" downshifts 944972 /Source="Nicolas_upshifts" /id="D438" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="2.62283" /MaxDrop="4.13562" /score="-4.23596421" /energy="-12.5" /TU="NA" /idTUdmin="U670" /TUdmin=0 /isTUend="TRUE" downshifts complement(944982) /Source="Nicolas_upshifts" /id="D439" /incds=0 /nref=182 /ntot=253 /MaxReadThrough="4.02571" /MaxDrop="6.23378" /score="9.51667757" /energy="-14.2" /TU="NA" /idTUdmin="U673" /TUdmin=0 /isTUend="TRUE" promotor_-35 945308..945312 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-35" promotor_-10 945320..945334 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-10" misc_feature complement(945324..945343) /Source="Nicolas_upshift_promotors" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 945324..945415 /Source="Nicolas_S_feature" /locus_tag="new_945324_945415" /HighExp="Cold, C30, H2O2, Etha, dia15, G135, Paraq, C90, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S302" upshifts 945324 /Source="Nicolas_upshifts" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" upshifts complement(945334) /Source="Nicolas_upshifts" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" promotor_-35 945392..945395 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-35" promotor_-10 945410..945429 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-10" S_feature 945417..945519 /Source="Nicolas_S_feature" /locus_tag="new_945417_945519" /HighExp="BMM, Cold, LBGstat, C30, Oxctl, LBGexp, Paraq, G180, Lbexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.996, 0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S303" upshifts 945417 /Source="Nicolas_upshifts" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" CDS 945520..946404 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388755.1" /db_xref="EnsemblGenomes-Gn:BSU08750" /db_xref="EnsemblGenomes-Tr:CAB12703" /db_xref="InterPro:IPR029348" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10951" /db_xref="UniProtKB/Swiss-Prot:Q04385" /translation="MENLLRPIYQERASHPNTLAVIMIERRNKTSSLTDNFDAALLVI VKDADEPVFIKHYEFDHQTASLHVVTDSQIQEWILLGTNRRIIDWIVNGRVLFDRNEY VVELIDRLNTFPFAERKLKIGLEYGKLIRRYVEGKAFFEANQFLDAYNAVVHALHHLA RIEVIDRGFHPETTVWSQVRQMEPQVYKLYSELIESHESLEKRLELLFLANDFLIHSK AEIGSAHLFEVMKEKDIWQFGELLQHHDLKHFTQDLGVMLDYLTEKGLINVCQIETKG QAVYHRGYSFKKGVDSDS*" gene 945520..946404 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" promotor_-35 946387..946394 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 946408..946427 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 946423..946695 /Source="Nicolas_S_feature" /locus_tag="new_946423_946695" /HighExp="LBGstat, Oxctl, C30, Paraq, GM 120, H2O2, HPh, G150, LPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.106881" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="Sig-" /TUlongPSig="0.0739" /label="S304" upshifts 946423 /Source="Nicolas_upshifts" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" downshifts complement(946456) /Source="Nicolas_upshifts" /id="D440" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="2.70619" /MaxDrop="3.85046" /score="4.43428373" /energy="-7.8" /TU="NA" /idTUdmin="U673" /TUdmin="-1474" /isTUend="FALSE" rRNA 946696..948250 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 946696..948250 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" rRNA 948418..951345 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 948418..951345 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" S_feature 951346..951431 /Source="Nicolas_S_feature" /locus_tag="new_951346_951431" /HighExp="G135, C30, Oxctl, Paraq, LBGstat, dia0, HiTm, Fru, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S305" promotor_-35 951407..951414 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 951428..951447 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 951433 /Source="Nicolas_upshifts" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" rRNA 951457..951572 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 951457..951572 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" tRNA 951582..951656 /gene="asnTA" /locus_tag="BSU_tRNA_29" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="asparagine transfer RNA (GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 951582..951656 /gene="asnTA" /locus_tag="BSU_tRNA_29" tRNA 951662..951753 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 951662..951753 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" downshifts 951749 /Source="Nicolas_upshifts" /id="D441" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="7.64297" /MaxDrop="4.37505" /score="-9.7424199" /energy="-11" /TU="U676" /idTUdmin="U677" /TUdmin="-1562" /isTUend="FALSE" tRNA 951788..951859 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 951788..951859 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" tRNA 951869..951944 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 951869..951944 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" tRNA 951954..952030 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 951954..952030 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" tRNA 952042..952118 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 952042..952118 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" tRNA 952131..952206 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Phe(GAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 952131..952206 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" tRNA 952212..952284 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 952212..952284 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" tRNA 952307..952391 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GUA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 952307..952391 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" tRNA 952397..952470 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" /product="tRNA-Trp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Trp(CCA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 952397..952470 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" tRNA 952495..952570 /gene="trnD-His" /locus_tag="BSU_tRNA_39" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="transfer RNA-His(GUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 952495..952570 /gene="trnD-His" /locus_tag="BSU_tRNA_39" tRNA 952580..952651 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 952580..952651 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" tRNA 952701..952775 /gene="glyTB" /locus_tag="BSU_tRNA_41" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="glycine transfer RNA (GCC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 952701..952775 /gene="glyTB" /locus_tag="BSU_tRNA_41" tRNA 952781..952851 /gene="cysTA" /locus_tag="BSU_tRNA_42" /product="tRNA-Cys" /inference="profile:tRNAscan:1.23" /note="cysteine tRNA (GCA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 952781..952851 /gene="cysTA" /locus_tag="BSU_tRNA_42" tRNA 952859..952947 /gene="leuTA" /locus_tag="BSU_tRNA_43" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine RNA (UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 952859..952947 /gene="leuTA" /locus_tag="BSU_tRNA_43" S_feature 952948..953024 /Source="Nicolas_S_feature" /locus_tag="new_952948_953024" /HighExp="Paraq, C30, Oxctl, G180, G135, Heat, BMM, LBGexp, dia15, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S306" downshifts 952981 /Source="Nicolas_upshifts" /id="D442" /incds=0 /nref=18 /ntot=231 /MaxReadThrough="5.36857" /MaxDrop="5.05259" /score="16.6649124" /energy="-8.9" /TU="U676" /idTUdmin="U677" /TUdmin="-330" /isTUend="FALSE" S_feature 953026..953194 /Source="Nicolas_S_feature" /locus_tag="new_953026_953194" /HighExp="Heat, Paraq, BMM, Oxctl, H2O2, Cold, G180, Pyr, C30, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S307" promotor_-35 953151..953158 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 953157 /Source="Nicolas_upshifts" /id="D443" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.84674" /MaxDrop="3.439" /score="35.1424037" /energy="-12.4" /TU="U676" /idTUdmin="U677" /TUdmin="-154" /isTUend="FALSE" promotor_-10 953172..953191 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 953196 /Source="Nicolas_upshifts" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" tRNA 953213..953294 /gene="leuTB" /locus_tag="BSU_tRNA_44" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine tRNA(CAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 953213..953294 /gene="leuTB" /locus_tag="BSU_tRNA_44" promotor_-10 complement(953230..953247) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(953233) /Source="Nicolas_upshifts" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(953268..953273) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(953303) /Source="Nicolas_upshifts" /id="D444" /incds=0 /nref=5 /ntot=151 /MaxReadThrough="1.64364" /MaxDrop="6.28675" /score="7.71223568" /energy="-12.4" /TU="NA" /idTUdmin="U679" /TUdmin=18 /isTUend="TRUE" CDS complement(953373..954149) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9795118, 22142536, 26625291, 28234965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9795118, 22142536, 26625291, 28234965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="protein involved in the control of the cell cycle as a function of the environment" /protein_id="NP_388756.2" /db_xref="EnsemblGenomes-Gn:BSU08760" /db_xref="EnsemblGenomes-Tr:CAB12704" /db_xref="GOA:P71088" /db_xref="InterPro:IPR009776" /db_xref="InterPro:IPR014756" /db_xref="PDB:5CL2" /db_xref="SubtiList:BG12229" /db_xref="UniProtKB/Swiss-Prot:P71088" /translation="MSFFKKLAASAGIGAAKVDTILEKDAYFPGEEVQGTVHVKGGKI AQDIRYIDLQLSTRYVIVKDDEEHRKYATIHSFRVTGSFTIQPGEEHQFPFTFTLPLD TPITVGKVEVAVVTDLDIQGGIDKSDHDRIFVEAHPWIENVLEAIENLGFRLNEADCE QAPYFQRRLPFVQEFEFVPTSGYYRQMLDELELIFLLDEDGLEIIFEVDRRARGLRGW LEEMYNDGEQLVRVRFSQSELEDTEELEEVLEEILDQYAE*" gene complement(953373..954149) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" downshifts complement(953387) /Source="Nicolas_upshifts" /id="D445" /incds=0 /nref=9 /ntot=131 /MaxReadThrough="6.06864" /MaxDrop="6.58787" /score="6.75662782" /energy="-7" /TU="U679" /idTUdmin="U679" /TUdmin="-66" /isTUend="FALSE" promotor_-10 complement(954176..954191) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(954198) /Source="Nicolas_upshifts" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" promotor_-35 complement(954204..954213) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 954233..954239 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 954254..954265 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 954257 /Source="Nicolas_upshifts" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" CDS 954291..954494 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388757.2" /db_xref="EnsemblGenomes-Gn:BSU08770" /db_xref="EnsemblGenomes-Tr:CAB12705" /db_xref="SubtiList:BG12981" /db_xref="UniProtKB/Swiss-Prot:O31586" /translation="MEVNKESLVADELHRMFLAGELQITVEEDINNISERLRNGDLSL DRLSGEDVFIKETVNEALRRVEQ*" gene 954291..954494 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" downshifts 954477 /Source="Nicolas_upshifts" /id="D446" /incds=0 /nref=22 /ntot=97 /MaxReadThrough="1.47004" /MaxDrop="5.47861" /score="15.4081475" /energy="-18.2" /TU="NA" /idTUdmin="U676" /TUdmin=0 /isTUend="TRUE" downshifts complement(954553) /Source="Nicolas_upshifts" /id="D447" /incds=0 /nref=10 /ntot=35 /MaxReadThrough="1.31339" /MaxDrop="4.8918" /score="26.0684119" /energy="-18.2" /TU="NA" /idTUdmin="U681" /TUdmin=0 /isTUend="TRUE" CDS complement(954579..954851) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="YP_003097696.1" /db_xref="EnsemblGenomes-Gn:BSU08779" /db_xref="EnsemblGenomes-Tr:CAX52583" /db_xref="GOA:C0H3X8" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="UniProtKB/Swiss-Prot:C0H3X8" /translation="MYRSKKQSQILSYQELLKKQRRWFPIEQSLCPKDILDLLTTIKT SINKYTVATTATENPHIRRALHDQLDTAVYLHDELSDLLLEKGWLG*" gene complement(954579..954851) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" promotor_-10 complement(954810..954828) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(954817) /Source="Nicolas_upshifts" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" promotor_-35 954832..954839 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-35" promotor_-35 complement(954845..954850) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 954852..954871 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-10" upshifts 954860 /Source="Nicolas_upshifts" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" CDS 954893..955585 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase" /protein_id="NP_388758.2" /db_xref="EnsemblGenomes-Gn:BSU08780" /db_xref="EnsemblGenomes-Tr:CAB12706" /db_xref="GOA:P71089" /db_xref="InterPro:IPR005320" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12230" /db_xref="UniProtKB/Swiss-Prot:P71089" /translation="MKQIIAMGGGGFSMEPDNLSLDQYILNQSKREQPRICFLPTASG DSQNYIQRFYHAFQTLDCVPSHLSLFKPPSSDLVSFVMEMDVIYVGGGNTRNLLVLWK EWGLDHILREAWKNGVVVAGISAGAICWFEEGVTDSAGPLTSLKSLGFLQGSFCPHYD GEKDRRPAYHQLISNKFLCSGYAADDGAALHFINDQLFQTVSSRSGAKAYRVMMAEHE IAEIPLPVKYLG*" gene 954893..955585 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" promotor_-35 955614..955618 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(955617..955636) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(955629) /Source="Nicolas_upshifts" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 955632..955651 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(955651..955658) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA 955655..955762 /gene="tswD" /locus_tag="BSU_misc_RNA_11" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" gene 955655..955762 /gene="tswD" /locus_tag="BSU_misc_RNA_11" upshifts 955662 /Source="Nicolas_upshifts" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" downshifts 955793 /Source="Nicolas_upshifts" /id="D448" /incds=0 /nref=13 /ntot=48 /MaxReadThrough="8.09735" /MaxDrop="5.74046" /score="17.5556194" /energy="-12.4" /TU="U684" /idTUdmin="U682" /TUdmin=152 /isTUend="FALSE" CDS 955895..957667 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" /EC_number="4.1.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8432721, 9370266, 10382260, 16291685, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8432721, 9370266, 10382260, 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine synthase" /protein_id="NP_388759.2" /db_xref="EnsemblGenomes-Gn:BSU08790" /db_xref="EnsemblGenomes-Tr:CAB12707" /db_xref="GOA:P45740" /db_xref="InterPro:IPR002817" /db_xref="InterPro:IPR025747" /db_xref="SubtiList:BG11246" /db_xref="UniProtKB/Swiss-Prot:P45740" /translation="MQNNSVQQANISIMSSFSGSKKVYVEGSSSDIQVPMREIALSPT TGSFGEEENAPVRVYDTSGPYTDPEVTINIQEGLKPLRQKWITERGDVEEYEGRAIKP EDNGYKKAKPNVSYPGLKRKPLRAKAGQNVTQMHYAKKGIITPEMEFIAIREHVSPEF VRDEVASGRAIIPSNINHPESEPMIIGRNFHVKINANIGNSAVTSSIEEEVEKMTWAI RWGADTMMDLSTGKDIHTTREWIIRNCPVPVGTVPIYQALEKVNGVAEDLTWEIYRDT LIEQAEQGVDYFTIHAGVLLRYVPLTAKRTTGIVSRGGAIMAQWCLAHHQESFLYTHF EEICEIMKMYDIAFSLGDGLRPGSIADANDEAQFAELETLGELTQIAWKHDVQVMIEG PGHVPMHKIKENVDKQMDICKEAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWYGTAM LCYVTPKEHLGLPNRDDVREGVITYKIAAHAADLAKGHPGAQIRDDALSKARFEFRWR DQFNLSLDPERALEYHDETLPAEGAKTAHFCSMCGPKFCSMRISQDIRDYAKKNDLSE AEAINKGLKEKAKEFVDTGSNLYQ*" gene 955895..957667 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" downshifts 957643 /Source="Nicolas_upshifts" /id="D449" /incds=0 /nref=166 /ntot=257 /MaxReadThrough="5.77069" /MaxDrop="5.3684" /score="25.2366359" /energy="-15.3" /TU="U684" /idTUdmin="U684" /TUdmin="-946" /isTUend="FALSE" S_feature 957688..958613 /Source="Nicolas_S_feature" /locus_tag="new_957688_958613" /HighExp="HiOs, GM-0.1, GM 45, GM 60, GM-0.2, BMM, MG 90, T-5.40H, MG 15, MG 25" /AntisenseName="ygaK" /AntisenseCor="-9.7288827054566707E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="SigA" /TUlongPSig=1 /label="S308" CDS complement(957705..959060) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" /EC_number="1.21.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8972604; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FAD-dependent oxido-reductase" /protein_id="NP_388760.2" /db_xref="EnsemblGenomes-Gn:BSU08800" /db_xref="EnsemblGenomes-Tr:CAB12708" /db_xref="GOA:Q796Y5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12231" /db_xref="UniProtKB/Swiss-Prot:Q796Y5" /translation="MEKTKLTGRIVTRDDPDYNEARTNINLSLERYPDIIVFCQNKQD ALNALKWARENRVPFRIRGGRHSYENFSLLNNGLVIDLSEMKKITVNQDKKLAYIEAG AELGEVYRTLWQYGLTLPAGTIANVGLTGLTLGGGIGLLTRAAGLTCDSLVQLEMIVA DEKEGADLITVSCSNHPDLFWASQGGGGGNFGIVTSMTFKAVPISQVSIFSITWGWDD FEEVYNTWQNWAPYTDDRLTSSIEFWPKEVNRIEALGQFVGPKTELKKLLKPLLKAGS PTSGMVKTTPFIEAVTFFNSPGGNQPQKMKRSGSFIEKPLSERAISTIKHFLEHAPNQ NASVWQQALGGAAGRVAPDQTAFYYRDAIIAQEYLTNWTSPGEKRQNVRWIEGLRTSL SKETMGDYVNWPDIEIRNWPRTYYGENVERLRRVKTTYDPENVFRFEQSIPPLRRSLF F*" gene complement(957705..959060) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" promotor_-10 complement(959088..959107) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(959105) /Source="Nicolas_upshifts" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" promotor_-35 complement(959121..959130) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 959178..959184 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 959199..959218 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 959227 /Source="Nicolas_upshifts" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" CDS 959311..959508 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1479343, 2108127, 8323536, 16321961" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1479343, 2108127, 8323536, 16321961; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (repressor of ScoC)" /protein_id="NP_388761.2" /db_xref="EnsemblGenomes-Gn:BSU08810" /db_xref="EnsemblGenomes-Tr:CAB12709" /db_xref="GOA:P21344" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG10747" /db_xref="UniProtKB/Swiss-Prot:P21344" /translation="MGVKKEKGRKRFRKRKTYGNQILPLELLIEKNKREIINSAELME EIYMKIDEKHTQCVTKYKKTR*" gene 959311..959508 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" CDS complement(959535..960986) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" /EC_number="1.11.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 12486061, 16535198, 22194458, 27935957" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12486061, 16535198, 22194458, 27935957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vegetative catalase 1" /protein_id="NP_388762.2" /db_xref="EnsemblGenomes-Gn:BSU08820" /db_xref="EnsemblGenomes-Tr:CAB12710" /db_xref="GOA:P26901" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG10849" /db_xref="UniProtKB/Swiss-Prot:P26901" /translation="MSSNKLTTSWGAPVGDNQNSMTAGSRGPTLIQDVHLLEKLAHFN RERVPERVVHAKGAGAHGYFEVTNDVTKYTKAAFLSEVGKRTPLFIRFSTVAGELGSA DTVRDPRGFAVKFYTEEGNYDIVGNNTPVFFIRDAIKFPDFIHTQKRDPKTHLKNPTA VWDFWSLSPESLHQVTILMSDRGIPATLRHMHGFGSHTFKWTNAEGEGVWIKYHFKTE QGVKNLDVNTAAKIAGENPDYHTEDLFNAIENGDYPAWKLYVQIMPLEDANTYRFDPF DVTKVWSQKDYPLIEVGRMVLDRNPENYFAEVEQATFSPGTLVPGIDVSPDKMLQGRL FAYHDAHRYRVGANHQALPINRARNKVNNYQRDGQMRFDDNGGGSVYYEPNSFGGPKE SPEDKQAAYPVQGIADSVSYDHYDHYTQAGDLYRLMSEDERTRLVENIVNAMKPVEKE EIKLRQIEHFYKADPEYGKRVAEGLGLPIKKDS*" gene complement(959535..960986) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" downshifts complement(959545) /Source="Nicolas_upshifts" /id="D450" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="1.32399" /MaxDrop="8.8938" /score="25.1548262" /energy="-8.3" /TU="NA" /idTUdmin="U688" /TUdmin=0 /isTUend="TRUE" promotor_-35 960963..960969 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 960984..961003 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 960987 /Source="Nicolas_upshifts" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" promotor_-10 complement(961004..961023) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 961009..961338 /Source="Nicolas_S_feature" /locus_tag="new_961009_961338" /HighExp="S8, C30, S7, S6, BT, C90, B36, S4, S5, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.528" /TUlongSig="NA" /TUlongPSig="NA" /label="S309" upshifts complement(961023) /Source="Nicolas_upshifts" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" promotor_-35 complement(961037..961044) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(961082..961100) /Source="Nicolas_upshift_promotors" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(961107) /Source="Nicolas_upshifts" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" downshifts 961295 /Source="Nicolas_upshifts" /id="D451" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="5.89897" /MaxDrop="4.66837" /score="39.0049465" /energy="-19.7" /TU="U687" /idTUdmin="U686" /TUdmin=1936 /isTUend="FALSE" CDS 961394..962161 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (ATP-bindingprotein)" /protein_id="NP_388763.3" /db_xref="EnsemblGenomes-Gn:BSU08830" /db_xref="EnsemblGenomes-Tr:CAB12711" /db_xref="GOA:P97027" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017875" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12232" /db_xref="UniProtKB/Swiss-Prot:P97027" /translation="MAVTISIKEKAFVQEGRKNTVLENIELSIAPGEFLTLIGPSGCG KSTLLKIIAGLDSEYDGSVEINGRSVTAPGIQQGFIFQEHRLFPWLTVEQNIAADLNL KDPKVKQKVDELIEIVRLKGSEKAYPRELSGGMSQRVAIARALLREPEVLLLDEPFGA LDAFTRKHLQDVLLDIWRKKKTTMILVTHDIDESVYLGNELAILKAKPGKIHKLMPIH LAYPRNRTTPDFQAIRQRVLSEFEKTEDLEYAEGSGI*" gene 961394..962161 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" CDS 962179..963177 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type f: factor" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (binding lipoprotein)" /protein_id="NP_388764.1" /db_xref="EnsemblGenomes-Gn:BSU08840" /db_xref="EnsemblGenomes-Tr:CAB12712" /db_xref="GOA:P40400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR010067" /db_xref="InterPro:IPR015168" /db_xref="SubtiList:BG10656" /db_xref="UniProtKB/Swiss-Prot:P40400" /translation="MKKGLIVLVAVIFLLAGCGANGASGDHKQLKEIRIGIQQSLSPL LIAKEKGWFEDAFEKEGIKVKWVEFQSGPPQFEGLAADKLDFSQVGNSPVIAGQAAGI DFKEIGLSQDGLKANGILVNQNSGIQDVKGLKGKKIAVAKGSSGFDFLYKALDQVGLS ANDVTIIQLQPDEAASAFENGSVDAWSIWEPYLSLETMKHGAKILVNGESTDLYSPGF TLVRTKFSEEHPDEVVRFLKVFNKAVVWQKEHLDEAADLYSDIKDLDKKVVENVLKNT EPLNEIISDDIVKAQQETADFQFRTKAIDKKIDVKDVVDNTFIKKALEEHSSGGDQ*" gene 962179..963177 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" CDS 963174..964004 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11390694, 15849754, 16513748, 16850406, 16885442, 9782504" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15849754, 16513748, 16850406, 16885442, 9782504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (permease)" /protein_id="NP_388765.1" /db_xref="EnsemblGenomes-Gn:BSU08850" /db_xref="EnsemblGenomes-Tr:CAB12713" /db_xref="GOA:P40401" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10657" /db_xref="UniProtKB/Swiss-Prot:P40401" /translation="MMKAEAAGSLPKTNAEAVRKKPGRKRYGWMKGLLLPAVIIAIWQ VIGGLGVVSATVLPTPVTIVLTFKELILSGELFGHLQISIYRAALGFLLGAGLGLMIG ILAGFSKRTELYLDPSLQMLRTVPHLAVTPLFILWFGFDEVSKILLIALGAFFPVYIN TFNGIRGVDAKLFEVARVLEFKWHQQISKVILPAALPNILLGIRLSLGIAWLGLVVAE LMGSSSGVGYMIMDARQFSQTNKVFAGIIIFAVVGKLTDSFVRLLERKLLKWRNSYEG *" gene 963174..964004 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" CDS 964027..965157 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" /EC_number="1.14.14.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9782504, 11390694, 16513748, 16885442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMNH2-dependent aliphatic sulfonate monooxygenase" /protein_id="NP_388766.2" /db_xref="EnsemblGenomes-Gn:BSU08860" /db_xref="EnsemblGenomes-Tr:CAB12714" /db_xref="GOA:P40402" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019911" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10658" /db_xref="UniProtKB/Swiss-Prot:P40402" /translation="MEILWFIPTHGDARYLGSESDGRTADHLYFKQVAQAADRLGYTG VLLPTGRSCEDPWLTASALAGETKDLKFLVAVRPGLMQPSLAARMTSTLDRISDGRLL INVVAGGDPYELAGDGLFISHDERYEATDEFLTVWRRLLQGETVSYEGKHIKVENSNL LFPPQQEPHPPIYFGGSSQAGIEAAAKHTDVYLTWGEPPEQVKEKIERVKKQAAKEGR SVRFGIRLHVIARETEQEAWEAAERLISHLDDDTIAKAQAALSRYDSSGQQRMAVLHQ GDRTKLEISPNLWAGIGLVRGGAGTALVGDPQTIADRIAEYQALGIESFIFSGYPHLE EAYYFAELVFPLLPFENDRTRKLQNKRGEAVGNTYFVKEKNA*" gene 964027..965157 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" misc_feature 965184..965203 /Source="Nicolas_upshift_promotors" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 965190 /Source="Nicolas_upshifts" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" CDS 965261..965797 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur-related oxidoreductase" /protein_id="NP_388767.1" /db_xref="EnsemblGenomes-Gn:BSU08870" /db_xref="EnsemblGenomes-Tr:CAB12715" /db_xref="SubtiList:BG12233" /db_xref="UniProtKB/Swiss-Prot:P97028" /translation="MLSACGHSKQMEIKAADISDLEKNRMDVAASQAFTAEAVNIGEG ISSADMYIEHYQKGKLVERFGPVRADYSEEKTDTIQFVYFENEEGEGKNKHTTIHFGI VDKQGTIAADSSVKRDDSTTQEMTQNISSPEPITFEKPALIGSSIRGTDETMHTSEHK KELIKHQDALLYYVELHH*" gene 965261..965797 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" S_feature 965798..965868 /Source="Nicolas_S_feature" /locus_tag="new_965798_965868" /HighExp="B36, BT, B60, Etha, S5, Heat, S2, BMM, S4, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25357200000000002" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S310" promotor_-35 965838..965845 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 965859..965878 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 965870 /Source="Nicolas_upshifts" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" CDS 965909..966178 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12904577, 17163968, 19648245, 20208344, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="alternative ribosomal protein S14" /protein_id="NP_388768.1" /db_xref="EnsemblGenomes-Gn:BSU08880" /db_xref="EnsemblGenomes-Tr:CAB12716" /db_xref="GOA:O31587" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023036" /db_xref="SubtiList:BG13085" /db_xref="UniProtKB/Swiss-Prot:O31587" /translation="MAKKSKVAKELKRQQLVEQYAGIRRELKEKGDYEALSKLPRDSA PGRLHNRCMVTGRPRAYMRKFKMSRIAFRELAHKGQIPGVKKASW*" gene 965909..966178 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" promotor_-35 965981..965985 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 966008..966024 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 966024 /Source="Nicolas_upshifts" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 966165 /Source="Nicolas_upshifts" /id="D452" /incds=0 /nref=41 /ntot=70 /MaxReadThrough="3.14088" /MaxDrop="6.23701" /score="18.4402235" /energy="-10.1" /TU="U692" /idTUdmin="U691" /TUdmin="-13" /isTUend="TRUE" CDS complement(966196..966669) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388769.1" /db_xref="EnsemblGenomes-Gn:BSU08890" /db_xref="EnsemblGenomes-Tr:CAB12717" /db_xref="GOA:P97029" /db_xref="SubtiList:BG12234" /db_xref="UniProtKB/Swiss-Prot:P97029" /translation="MSMKTKAAFHLVLFGLACWALISYFEASEGIASFFGTKSGGMVF DLNLTPFILFVAASAVYLYLQKKSRPARKQLLLPDEFEEQDEREQMMTAKACRASYIA VYFSLPAAAVLLIFYPLFQSRIPFFPIIIVFIIMIIQHLSYVISFKKNEKNSGAL*" gene complement(966196..966669) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" downshifts complement(966232) /Source="Nicolas_upshifts" /id="D453" /incds=0 /nref=105 /ntot=235 /MaxReadThrough="1.59724" /MaxDrop="4.17785" /score="7.33161195" /energy="-10.1" /TU="NA" /idTUdmin="U693" /TUdmin=0 /isTUend="TRUE" CDS complement(966671..966871) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative HTH-type transcriptional regulator" /protein_id="YP_003097697.1" /db_xref="EnsemblGenomes-Gn:BSU08899" /db_xref="EnsemblGenomes-Tr:CAX52584" /db_xref="GOA:C0H3X9" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="UniProtKB/Swiss-Prot:C0H3X9" /translation="MKNKVKELRARFGYSQEKLGETVGVTRQTVAAIEKGDYVPSLLL ALKICKAFSMKMEDVFWLEEEN*" gene complement(966671..966871) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" promotor_-10 complement(966900..966919) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(966914) /Source="Nicolas_upshifts" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" promotor_-35 complement(966932..966939) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 966995..967000 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 967014..967033 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 967014 /Source="Nicolas_upshifts" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" tRNA 967065..967138 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(TCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 967065..967138 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" S_feature 967139..967321 /Source="Nicolas_S_feature" /locus_tag="new_967139_967321" /HighExp="G135, G180, Oxctl, G150, Paraq, H2O2, C30, HPh, LPh, LBGexp" /AntisenseName="yhzB" /AntisenseCor="0.42714037049296899" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S311" CDS complement(967229..967852) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388771.1" /db_xref="EnsemblGenomes-Gn:BSU08900" /db_xref="EnsemblGenomes-Tr:CAB12718" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG13086" /db_xref="UniProtKB/Swiss-Prot:O31588" /translation="MNIKLDSVITERAAGLHAAAVIYENIEVGSSPQMLKGRLRLFQE SLFFDYADGGISDESFVKEWQKLFKQLNPSFEGETTPMEDMLVPISKEQFMESKDSAH DTIDFFALKYSLPIMIYDAGKLHEPVRISLGEKENILLFSDENGIFGDFKNSVNHYPV SNETKNMLQIIFFPPSIEKSSAVNLLSSLTKMFEQIHGGTHTVHWLT*" gene complement(967229..967852) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" downshifts complement(967244) /Source="Nicolas_upshifts" /id="D454" /incds=0 /nref=25 /ntot=165 /MaxReadThrough="2.50849" /MaxDrop="4.62652" /score="-8.52782087" /energy="-7.9" /TU="NA" /idTUdmin="U695" /TUdmin=0 /isTUend="TRUE" downshifts 967278 /Source="Nicolas_upshifts" /id="D455" /incds=0 /nref=1 /ntot=88 /MaxReadThrough="4.14204" /MaxDrop="2.36986" /score="16.0836885" /energy="-15.5" /TU="U694" /idTUdmin="U692" /TUdmin=1078 /isTUend="FALSE" S_feature 967323..967934 /Source="Nicolas_S_feature" /locus_tag="new_967323_967934" /HighExp="G180, G135, G150, Paraq, Oxctl, H2O2, LBGstat, Cold, LBGexp, S6" /AntisenseName="yhzB" /AntisenseCor="0.28959466335762701" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S312" promotor_-10 complement(967876..967895) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(967897) /Source="Nicolas_upshifts" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" promotor_-35 complement(967909..967916) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 967935..969095 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" /EC_number="1.17.99.-" /function="10.3: tRNA and rRNA base modification" /experiment="publication(s) with functional evidences, PMID:8830270, 21502530, 26230193, 27638883, 28128549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830270, 21502530, 26230193, 27638883, 28128549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epoxyqueuosine reductase" /protein_id="NP_388772.2" /db_xref="EnsemblGenomes-Gn:BSU08910" /db_xref="EnsemblGenomes-Tr:CAB12719" /db_xref="GOA:P97030" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR004453" /db_xref="InterPro:IPR013542" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="PDB:5D08" /db_xref="PDB:5D0A" /db_xref="PDB:5D0B" /db_xref="PDB:5T8Y" /db_xref="SubtiList:BG12236" /db_xref="UniProtKB/Swiss-Prot:P97030" /translation="MNVYQLKEELIEYAKSIGVDKIGFTTADTFDSLKDRLILQESLG YLSGFEEPDIEKRVTPKLLLPKAKSIVAIALAYPSRMKDAPRSTRTERRGIFCRASWG KDYHDVLREKLDLLEDFLKSKHEDIRTKSMVDTGELSDRAVAERAGIGFSAKNCMITT PEYGSYVYLAEMITNIPFEPDVPIEDMCGSCTKCLDACPTGALVNPGQLNAQRCISFL TQTKGFLPDEFRTKIGNRLYGCDTCQTVCPLNKGKDFHLHPEMEPDPEIAKPLLKPLL AISNREFKEKFGHVSGSWRGKKPIQRNAILALAHFKDASALPELTELMHKDPRPVIRG TAAWAIGKIGDPAYAEELEKALEKEKDEEAKLEIEKGIELLKASGMTKQGLS*" gene 967935..969095 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" downshifts 969104 /Source="Nicolas_upshifts" /id="D456" /incds=0 /nref=9 /ntot=123 /MaxReadThrough="5.29174" /MaxDrop="3.3561" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U694" /TUdmin=0 /isTUend="TRUE" misc_feature 969121..969133 /Source="Nicolas_upshift_promotors" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 969126 /Source="Nicolas_upshifts" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" CDS 969162..970097 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388773.1" /db_xref="EnsemblGenomes-Gn:BSU08920" /db_xref="EnsemblGenomes-Tr:CAB12720" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG11811" /db_xref="UniProtKB/Swiss-Prot:O31589" /translation="MAGGVSLKYILEQLAEERLGFLVNGHAMRQESQVGDLKVMERKK KLLEKRKVDIIKAKAKAVINHVRVEDDGTTCLSYTIHYEYVCKEQDDSLYIEEHIEER MAFLYDHILISDQEIAKKPAGFHEGTSIIDYSEAEEEREAFGRAFQYDRLGAVQYAEK FWNKRNPAYKNFSDNCTNFISQCLHAGGAPMRGHPNRGSGWWMKQSSWSYSWTVAHSM KMYLSNSKAGLRAVRVKSAEELMPGDVICYDFEGDGRFNHTTIVVAKDKGNMPLVNAQ TYDSRMRYWSYEDSTAYTPSIRYAFFHIVDDTTKE*" gene 969162..970097 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" downshifts complement(969180) /Source="Nicolas_upshifts" /id="D457" /incds=0 /nref=2 /ntot=17 /MaxReadThrough="2.06584" /MaxDrop="3.33944" /score="-3.35852865" /energy="-6" /TU="NA" /idTUdmin="U695" /TUdmin="-1936" /isTUend="FALSE" promotor_-35 970081..970084 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 970099 /Source="Nicolas_upshifts" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" promotor_-10 970100..970119 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 970135..970617 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" /EC_number="2.1.1.207" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 20855540; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (cytidine(34)-2'-O)-methyltransferase" /protein_id="NP_388774.2" /db_xref="EnsemblGenomes-Gn:BSU08930" /db_xref="EnsemblGenomes-Tr:CAB12721" /db_xref="GOA:O31590" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR016914" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG11802" /db_xref="UniProtKB/Swiss-Prot:O31590" /translation="MNIVALHVVLYQPEIPANTGNIARTCAATNTTLHLIRPLGFSTD DKMLKRAGLDYWEFVNVVYHDSLEELFEAYKKGKFFFITKFGQQPHTSFDYTDLDEDY FFVFGRETSGLPKDLIQNNMDRCLRLPMTEHVRSLNLSNTAAILVYEALRQQNYRDLK *" gene 970135..970617 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" downshifts 970600 /Source="Nicolas_upshifts" /id="D458" /incds=0 /nref=203 /ntot=259 /MaxReadThrough="4.6846" /MaxDrop="7.03587" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U696" /TUdmin=0 /isTUend="TRUE" CDS 970667..971383 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="NP_388775.1" /db_xref="EnsemblGenomes-Gn:BSU08940" /db_xref="EnsemblGenomes-Tr:CAB12722" /db_xref="InterPro:IPR025063" /db_xref="SubtiList:BG12237" /db_xref="UniProtKB/Swiss-Prot:P97032" /translation="MLCFVFGLNNVTVLCYNVPIKGAGLMEEQLISKKELLERTSISY GQLYRWKRKNLIPEEWFIRKSTFTGQETFFPREEILKRISMIQKMKENLSLDEMREML SPKMKDVSMTADELLHKGLVSRPALEAYSEDGGSPVFSSSDLLSLFVLEGLLQSGNVS LAEAKMAAEVLKKHDTEEIEKQTELIVLRKLGVTTCFIAAAADSILFESSVKVVERVD LLKASEELKTTFMQEGHQWM*" gene 970667..971383 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" promotor_-35 970687..970694 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 970709..970728 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 970710 /Source="Nicolas_upshifts" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" CDS 971374..972087 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388776.1" /db_xref="EnsemblGenomes-Gn:BSU08950" /db_xref="EnsemblGenomes-Tr:CAB12723" /db_xref="InterPro:IPR007607" /db_xref="SubtiList:BG10802" /db_xref="UniProtKB/Swiss-Prot:P39132" /translation="MDVVEKLVINGSGSSKGGTFQSVEINGSGTVAGDVECDTFSFNG NGKADGSVKAKAVTISGSGKIHGDVEAESIRMNGTGFIQGEVSAKQLKIAGSSTFGGT VKADGIDISGKAVMEADCETETFQSEGKCKISGLLNADQVIIKLSAGESYAREIGCRH LQVTCRKGMLTLLRLMPQPVLTAELIEGDVIELTNTKAKTVRGNKVIIGPDCQIETVE YSGDYTCDPSASVETSTKL*" gene 971374..972087 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" CDS 972099..972806 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388777.2" /db_xref="EnsemblGenomes-Gn:BSU08960" /db_xref="EnsemblGenomes-Tr:CAB12724" /db_xref="SubtiList:BG10803" /db_xref="UniProtKB/Swiss-Prot:P39133" /translation="METTKLGNLKLYGAGHAAGGAYHNVSIKGEGIVGEGLSAVGCRI YGTGLFLGKAETERLRVLGESECKGDLTAGKINIYGTMKVSGSLQFDRFNLKGQTEIG GNMTGESCDVKGKLSVIGDCETEMFHVTGCVDVSGLLNSGEIKLGLSHDISHVQEIGG TTITVKRRASFFSRKKGKLIADVIEGDRVYLENTEAAVVRGKEVIIGPGCSIGTIEYE YKCECDPHSQIKEKTKL*" gene 972099..972806 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" downshifts 972690 /Source="Nicolas_upshifts" /id="D459" /incds=1 /nref=1 /ntot=127 /MaxReadThrough="4.34704" /MaxDrop="2.64409" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-110" /isTUend="FALSE" downshifts 972734 /Source="Nicolas_upshifts" /id="D460" /incds=1 /nref=2 /ntot=35 /MaxReadThrough="4.02504" /MaxDrop="3.21894" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-66" /isTUend="FALSE" downshifts 972800 /Source="Nicolas_upshifts" /id="D461" /incds=0 /nref=2 /ntot=41 /MaxReadThrough="1.06365" /MaxDrop="3.74046" /score="45.497414" /energy="-15.3" /TU="NA" /idTUdmin="U698" /TUdmin=0 /isTUend="TRUE" S_feature complement(972833..973008) /Source="Nicolas_S_feature" /locus_tag="new_972833_973008_c" /HighExp="M9-stat, BC, S4, T0.30H, LoTm, Lbstat, S2, BT, HiOs, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99846699999999999" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S313" downshifts complement(972876) /Source="Nicolas_upshifts" /id="D462" /incds=0 /nref=63 /ntot=220 /MaxReadThrough="3.38525" /MaxDrop="4.33005" /score="18.2489321" /energy="-13.5" /TU="U699" /idTUdmin="U699" /TUdmin="-198" /isTUend="FALSE" promotor_-10 complement(973000..973019) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(973008) /Source="Nicolas_upshifts" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" promotor_-35 complement(973034..973041) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 973073..973078 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 973094..973112 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 973094 /Source="Nicolas_upshifts" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" CDS 973156..975051 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8626065, 12662922, 25983726, 27806131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8626065, 12662922, 25983726, 27806131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine protein kinase (involved in sporulation)" /protein_id="NP_388778.1" /db_xref="EnsemblGenomes-Gn:BSU08970" /db_xref="EnsemblGenomes-Tr:CAB12725" /db_xref="GOA:P39134" /db_xref="InterPro:IPR010650" /db_xref="InterPro:IPR013153" /db_xref="InterPro:IPR016230" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10804" /db_xref="UniProtKB/Swiss-Prot:P39134" /translation="MDILKKIEKYREEEQRLKWEGTFADYLEIIKENPMVAQSAHSRV FNMIKDSGIEEIDGRKKYSFFDRELFGLEESLERLVEEYFHPAAKRLDVRKRILLLMG PVSGGKSTLVTMLKKGLEAYTLTDNGAVYAIKGCPMHEDPLHLIPHHLRDDFYREYGI RIEGSLSPLNVMRLEEEYGGRIEDVKVERIFFSEDKRTGIGTFSPSDPKSQDIADLTG SIDFSTIAEYGSESDPRAYRFDGELNKANRGMMEFQEMLKCDEKFLWHLLSLTQEGNF KAGRFALISADELIVAHTNETEYRSFISNKKNEALHSRIIVMPVPYNLKVSEEERIYE KMIAESDVADVHIAPHTLKVAAMFSILTRLKEPKRSDIDLVKKMRLYDGESVEGYNSV DVEDMKKEYNDEGMSGIDPRYVINRISSTIIRKNMESINSLDVLRSLKEGLDQHPSIS SEDRERYLNFISAARKEYDDIAKKEVQKAFVYSYEESAKTLMDNYLDNVEAYCNKNKL RDPLTGEEMNPDEKLMRSIEEQIGISENAKKAFREEILIRISAYARKGKRFDYNSHER LREAIQKKLFADLKDVVKITTSTKTPDEQQLKKVNEVVARLIDEHGYNSTSANELLKY VGSLLNR*" gene 973156..975051 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" promotor_no_box 973598..973698 /Source="Nicolas_upshift_promotors" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 973658 /Source="Nicolas_upshifts" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 973724 /Source="Nicolas_upshifts" /id="D463" /incds=1 /nref=5 /ntot=18 /MaxReadThrough="7.33384" /MaxDrop="5.65132" /score="45.497414" /energy="-15.3" /TU="U700" /idTUdmin="U701" /TUdmin=0 /isTUend="TRUE" downshifts 975044 /Source="Nicolas_upshifts" /id="D464" /incds=0 /nref=11 /ntot=57 /MaxReadThrough="6.19375" /MaxDrop="4.381" /score="-0.497429548" /energy="-10.6" /TU="U700" /idTUdmin="U703" /TUdmin="-528" /isTUend="FALSE" promotor_-35 975108..975113 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 975129..975147 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 975132..975230 /Source="Nicolas_S_feature" /locus_tag="new_975132_975230" /HighExp="S6, S7, S5, S8, S4, S3, BT, LoTm, B36, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.971, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S314" upshifts 975132 /Source="Nicolas_upshifts" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" CDS 975231..976409 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11988534, 12662922, 14523133, 25983726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 12662922, 14523133, 25983726; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination" /protein_id="NP_388779.1" /db_xref="EnsemblGenomes-Gn:BSU08980" /db_xref="EnsemblGenomes-Tr:CAB12726" /db_xref="InterPro:IPR006698" /db_xref="InterPro:IPR014230" /db_xref="SubtiList:BG11238" /db_xref="UniProtKB/Swiss-Prot:P45742" /translation="MSQNDSGHFLISEENWSLHRKGFDDQQRHQKKVQEAIKNNLPDL VTEESIIMSNGKDVVKIPIRSLDEYKIRYNYDKNKHVGQGDGESQVGDVVARDGSDKK QGPGKGQGAGDQAGEDYYEAEVSLMDLEEALFKELELPNLQQKERDNIIHTDIEFNDI RKTGLTGNIDKKRTMMSAFKRNAMSGKPSFYPIYPEDLKYKTWNDITKPESKAVVLAM MDTSGSMGVWEKYMARSFFFWMTRFLRTKYETVEIEFIAHHTEARVVSEEDFFSKGES GGTICSSVYRKSLELIDEKYNPARYNIYPFHFSDGDNLTSDNARCVKLVNDIMKKANL FCYGEVNQYNRHSTLMSAYKNVKDEKFKYYILKQKSDVFQALKNFFRNEESGVSHQFS *" gene 975231..976409 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" promotor_-35 975429..975432 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 975447..975466 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 975451 /Source="Nicolas_upshifts" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts complement(975692) /Source="Nicolas_upshifts" /id="D465" /incds=1 /nref=1 /ntot=23 /MaxReadThrough="2.79078" /MaxDrop="2.94521" /score="-7.1109433" /energy="-11.2" /TU="NA" /idTUdmin="U699" /TUdmin="-3014" /isTUend="FALSE" downshifts 976388 /Source="Nicolas_upshifts" /id="D466" /incds=0 /nref=63 /ntot=180 /MaxReadThrough="1.86673" /MaxDrop="8.19565" /score="27.3980811" /energy="-5.6" /TU="NA" /idTUdmin="U702" /TUdmin=2 /isTUend="TRUE" promotor_-35 976496..976503 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 976518..976537 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 976518 /Source="Nicolas_upshifts" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" CDS 976569..977033 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)induced by acid stress" /protein_id="NP_388780.1" /db_xref="EnsemblGenomes-Gn:BSU08990" /db_xref="EnsemblGenomes-Tr:CAB12727" /db_xref="GOA:O31592" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13003" /db_xref="UniProtKB/Swiss-Prot:O31592" /translation="MTESERALLTFEQLFDTSRAIYKKQKKILEIVLEPFDITVLQYL LMFKIHQSGSTPLSKLAMSLDLKPASVTRMTDILYKRQLMNRYDSPDDRRIVMIQLTE EGEELIEKAAVQYAKMGAGLYQKLDTSQLQYLRKLAGSLTKLAEGCSEKSGN*" gene 976569..977033 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" promotor_-35 976858..976864 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 976879..976897 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 976892 /Source="Nicolas_upshifts" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" promotor_-35 977042..977048 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 977062..977073 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 977068 /Source="Nicolas_upshifts" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" CDS 977069..977734 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane fusion protein; putative exporter subunit (benzoate transcriptome)" /protein_id="NP_388781.1" /db_xref="EnsemblGenomes-Gn:BSU09000" /db_xref="EnsemblGenomes-Tr:CAB12728" /db_xref="GOA:O31593" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG13004" /db_xref="UniProtKB/Swiss-Prot:O31593" /translation="MIEDETKGENKMNRGRLILTNIIGLIVVLAIIAGGAYYYYQSTN YVKTDEAKVAGDMAAITAPAAGKVSDWDLDEGKTVKKGDTVAKIKGEQTVDVKSIMDG TIVKNEVKNGQTVQAGTTIAQTIDMDNLYITANIKETDIADIEVGNSVDVVVDGDPDT TFDGTVEEIGYATNSTFDMLPSTNSSGNYTKVTQKVPVKISIKNPSDKVLPGMNASVK ISE*" gene 977069..977734 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" CDS 977775..979373 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter (benzoate transcriptome)" /protein_id="NP_388782.1" /db_xref="EnsemblGenomes-Gn:BSU09010" /db_xref="EnsemblGenomes-Tr:CAB12729" /db_xref="GOA:P54585" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11579" /db_xref="UniProtKB/Swiss-Prot:P54585" /translation="MATGKEKNAKNPMSLLIVLMAGLFLAILNQTLLNVAMPHLMTEF GVSATTIQWLTTGYMLVNGVLIPLSAFLITRFGQRSLFLVAMFCFTLGTLVCGIAPNF STMLIGRLIQAVGGGILQPLVMTTILLIFPPESRGKGMGIFGLAMMFAPAVGPTLSGW IIEHYTWRIMFYGLVPIGAIVIIVAFFIFKNMVEPQKIKLDTLGAILSIVGFASLLYG VSEAGSDGWTDPIVLSTVIIGAIAIVAFVVQQLRHDDPMLDFRVFKYDIFSLSSVINI IITVALYTGMFLLPIYLQNLVGFTALQSGLLLLPGAIVMLIMSPISGILFDKFGPRPL AIIGLLVTVVTTYQYTQLTIDTPYTHIMLIYSIRAFGMSLLMMPVMTAGMNQLPARLN SHGTAMSNTLRQISGSIGTSLITTIYTNRTTFHYSQIADKTSTADPNFLHAFQNAVSN LMVNMNVSYDTAKTYVYSHIYKHASLDSNVMGINDAFMWATLFCVAGLILSIFLRDVR KDKLRKKKKEELSLLPAPKEAKES*" gene 977775..979373 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" CDS 979396..979926 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" /EC_number="1.6.5.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15754243, 18041955, 17951395, 19665595, 20011599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:quinone oxidoreductase associated to benzoate stress" /protein_id="NP_388783.1" /db_xref="EnsemblGenomes-Gn:BSU09020" /db_xref="EnsemblGenomes-Tr:CAB12730" /db_xref="GOA:P54586" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11580" /db_xref="UniProtKB/Swiss-Prot:P54586" /translation="MKIYVVYDSEGEHTKVLAEAIAEGARENDAAEVFIDHVDQADIR KLKDMDAIIWGCPGHFGTISSGLKTWIDRLGYLWAEGELINKVGAVFCTTATTHGGLE MTMHNLITPMFHQGMIVVGLPGNVPENALYGSYYGAGVTCPVDSDELMSEEGIQLGRA LGRRVSQVTGNLTAGQ*" gene 979396..979926 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" CDS 979939..980313 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical membrane protein" /protein_id="NP_388784.1" /db_xref="EnsemblGenomes-Gn:BSU09030" /db_xref="EnsemblGenomes-Tr:CAB12731" /db_xref="GOA:P54587" /db_xref="SubtiList:BG11581" /db_xref="UniProtKB/Swiss-Prot:P54587" /translation="MAIIIAIIAAVIVIAALITFNVRNASPGPEKQEATDRIAPPEEE KNEAHYPAEARAAEHTPSVVKNDSPKEKRDTMGDDIYRQALQKFKHSDEVHAEEEVTE ESDKMQDRSYRDALLSMKNKKK*" gene 979939..980313 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" downshifts 980302 /Source="Nicolas_upshifts" /id="D467" /incds=0 /nref=32 /ntot=145 /MaxReadThrough="1.78742" /MaxDrop="5.9171" /score="13.777309" /energy="-14.4" /TU="NA" /idTUdmin="U704" /TUdmin=0 /isTUend="TRUE" CDS 980313..980468 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388785.1" /db_xref="EnsemblGenomes-Gn:BSU09040" /db_xref="EnsemblGenomes-Tr:CAB12732" /db_xref="SubtiList:BG11582" /db_xref="UniProtKB/Swiss-Prot:P54588" /translation="MKKANPFTHAGLPFLLFPSIMFLSNKSMEYVVFHLDLVYYVTHT PRIFSGR*" gene 980313..980468 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" promotor_-35 980403..980409 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 980424..980443 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 980434 /Source="Nicolas_upshifts" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" CDS 980473..981234 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane orphan protein" /protein_id="NP_388786.1" /db_xref="EnsemblGenomes-Gn:BSU09050" /db_xref="EnsemblGenomes-Tr:CAB12733" /db_xref="GOA:P54589" /db_xref="SubtiList:BG11583" /db_xref="UniProtKB/Swiss-Prot:P54589" /translation="MNSFLGLLKKDIKLSRMWLLVWICGIIFLLGTGHIIASRTKEPL VIFGFFVAVAFFLLFLSPVFVFYHLRKEGKSQLWLYNPNGGLWLFSSKLAASLLYQFV IQLALTAYGIWMYHMLSVKNLLEHQVDITSTVALLNMYGLISSLDMSVTVIVFWTVFH SLRNWRGMRWAAMVLLVAMWLFFDEYIISPLVESQKHFWPVTVYCNFDFHFHNVWRLE LKPIHLSVLGFPIAIVITFLLLIMASKLLDRKVEV*" gene 980473..981234 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" promotor_-10 complement(980786..980804) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(980800) /Source="Nicolas_upshifts" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(980820..980825) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 981237..981602 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_388787.1" /db_xref="EnsemblGenomes-Gn:BSU09060" /db_xref="EnsemblGenomes-Tr:CAB12734" /db_xref="GOA:P54590" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11584" /db_xref="UniProtKB/Swiss-Prot:P54590" /translation="MDNQFQSSKPIYLQIADQIFYRLVRKELLPGDKLPSVREMAIQT KVNPNTIQRTYSEMERLGIVETRRGQGTFIAEKAEIVDELKDKLTREVLEGFVKQMKE LGLTKEEMLEGIKTFTEGG*" gene 981237..981602 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" CDS 981604..982302 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter ATP-binding protein" /protein_id="NP_388788.1" /db_xref="EnsemblGenomes-Gn:BSU09070" /db_xref="EnsemblGenomes-Tr:CAB12735" /db_xref="GOA:P54591" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11585" /db_xref="UniProtKB/Swiss-Prot:P54591" /translation="MEIKLEHVSKKYGRHTAVNDVSITLSSGRIYGLIGPNGSGKSTT LKMMAGLLFPTSGFVKVDEEQVTREMVRQTAYLTELDMFYPHFTVKDMVNFYQSQFPD FHTEQVYKLLNEMQLNPEKKIKKLSKGNRGRLKIVLALARRADVILLDEPFSGLDPMV RDSIVNSLVSYIDFEQQIVVIATHEIDEIETLLDEVIILANGEKVAQREVEDIREQEG MSVLQWFKSKMEVC*" gene 981604..982302 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" CDS 982319..983236 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7476193, 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388789.1" /db_xref="EnsemblGenomes-Gn:BSU09080" /db_xref="EnsemblGenomes-Tr:CAB12736" /db_xref="GOA:P54592" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11586" /db_xref="UniProtKB/Swiss-Prot:P54592" /translation="MKTVLELKNVTKNIRGRTIIDDLSFTIREGEVFGFLGPNGAGKT TTIRMMVGLMKLSKGDVLICGQSITKEYAKAIKHIGAIVENPELYKFLSGYKNLQQFA RMVKGVTKEKIDEVVELVGLTDRIHDKVKTYSLGMRQRLGLAQCLLHDPKVLILDEPT NGLDPAGIREIRDHLKKLTRERGMAVIVSSHLLSEMELMCDRIAILQKGKLIDIQNVK DENIDENDTYFFQVEQPSEAATVLNQYDLLSKTNGVEIKLAKEEVPAVIELLVMQQIR IYEVKVITKSLEDRFLEMTGETKEEVQHA*" gene 982319..983236 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" CDS 983229..984170 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 15870467, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_388790.1" /db_xref="EnsemblGenomes-Gn:BSU09090" /db_xref="EnsemblGenomes-Tr:CAB12737" /db_xref="GOA:P54593" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11587" /db_xref="UniProtKB/Swiss-Prot:P54593" /translation="MLNLIYNEWLKIFSRAGTWVMIGILGLTMVGFAFLANHFSAGES NSHWKQELQAQNAELKKEIKEDPSLKDGYKETITLNDYRIEHNIPSDTGYTVWSYVTD SANFTILTGLFTIIIAAGIVANEFNWGTIKLLMIRPLSRFQILMSKYITVLLFGLLLL LILFIGSTLLGLIFFGTGGETAANIHLIYKDGHVIEQNMMGHLATTYLSESVSALMVA TMAFMLSAVFRNSSLAVGFSIFLLVAGTTATAFIAAKFDWAKYILFANVDLTQYVDGT PLIKGMTMTFSLVMLAIYFIIFLLLAFGIFMKRDIAN*" gene 983229..984170 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" downshifts 984152 /Source="Nicolas_upshifts" /id="D468" /incds=0 /nref=43 /ntot=186 /MaxReadThrough="2.67567" /MaxDrop="4.46232" /score="20.0218504" /energy="-13.6" /TU="NA" /idTUdmin="U707" /TUdmin=0 /isTUend="TRUE" CDS complement(984262..984465) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12493834, 16352840, 22128343, 25851716" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12493834, 16352840, 22128343, 25851716; Product type f: factor" /codon_start=1 /transl_table=11 /product="major cold-shock protein, RNA helicase co-factor, RNA co-chaperone" /protein_id="NP_388791.1" /db_xref="EnsemblGenomes-Gn:BSU09100" /db_xref="EnsemblGenomes-Tr:CAB12738" /db_xref="GOA:P32081" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="PDB:1CSP" /db_xref="PDB:1CSQ" /db_xref="PDB:1NMF" /db_xref="PDB:1NMG" /db_xref="PDB:2ES2" /db_xref="PDB:2F52" /db_xref="PDB:2I5L" /db_xref="PDB:2I5M" /db_xref="PDB:3PF4" /db_xref="PDB:3PF5" /db_xref="SubtiList:BG10824" /db_xref="UniProtKB/Swiss-Prot:P32081" /translation="MLEGKVKWFNSEKGFGFIEVEGQDDVFVHFSAIQGEGFKTLEEG QAVSFEIVEGNRGPQAANVTKEA*" gene complement(984262..984465) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" downshifts complement(984276) /Source="Nicolas_upshifts" /id="D469" /incds=0 /nref=169 /ntot=281 /MaxReadThrough="5.28215" /MaxDrop="9.14889" /score="33.2405587" /energy="-13.1" /TU="U710" /idTUdmin="U710" /TUdmin="-48" /isTUend="FALSE" S_feature complement(984466..984593) /Source="Nicolas_S_feature" /locus_tag="new_984466_984593_c" /HighExp="BC, C90, GM 15, BI, T-1.10H, UNK1, S1, Sw, nit, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S315" misc_feature 984553..984564 /Source="Nicolas_upshift_promotors" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 984570 /Source="Nicolas_upshifts" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(984582..984601) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(984593) /Source="Nicolas_upshifts" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" S_feature complement(984595..985733) /Source="Nicolas_S_feature" /locus_tag="new_984595_985733_c" /HighExp="C30, G180, G150, Oxctl, G135, Paraq, HPh, LPh, dia0, Lbexp" /AntisenseName="yhcJ" /AntisenseCor="0.25433958616302499" /AntisenseRegPval="-4.5999999999999996" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S316" promotor_-35 complement(984615..984620) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 984760..984767 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 984782..984800 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 984789 /Source="Nicolas_upshifts" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" S_feature 984790..984900 /Source="Nicolas_S_feature" /locus_tag="new_984790_984900" /HighExp="Diami, dia15, dia5, H2O2, Salt, C90, Paraq, UNK1, T-4.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S317" CDS 984901..985731 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_388792.2" /db_xref="EnsemblGenomes-Gn:BSU09110" /db_xref="EnsemblGenomes-Tr:CAB12739" /db_xref="GOA:P54594" /db_xref="InterPro:IPR004872" /db_xref="SubtiList:BG11588" /db_xref="UniProtKB/Swiss-Prot:P54594" /translation="MKKWLICSFVLVLLVSFTACSPSAEHESIKIGIAESDGAIWNYI AQKAEEAGLDIQLIPFSDYAESDIALANKEIDANAFQTISYFQSFTEKYKLNLAPLGT TYITPMGIYSKRYERIRDISRGAVVSVPDKAFDFGRALTVLQEAGLLTLKNGFNGTGS VDMIKDNPRHLKLKAVRQQDAVSGADVFVMKPSEAKKAGLNPKKHTLKSGGLMSEEEM NLIVVRAEDQDREALQTILELYQADDTAAFIEKEYQGDLVPAFLPLKRLSDWKNEFEH *" gene 984901..985731 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" downshifts 985690 /Source="Nicolas_upshifts" /id="D470" /incds=0 /nref=38 /ntot=203 /MaxReadThrough="2.83059" /MaxDrop="3.90173" /score="-4.94928928" /energy="-7.3" /TU="NA" /idTUdmin="U711" /TUdmin="-3" /isTUend="TRUE" CDS complement(985734..986813) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_388793.1" /db_xref="EnsemblGenomes-Gn:BSU09120" /db_xref="EnsemblGenomes-Tr:CAB12740" /db_xref="GOA:P54595" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG11589" /db_xref="UniProtKB/Swiss-Prot:P54595" /translation="MLKELFVNLTILITFNYLFTHLFKERLVHKKDSISFQAVKGLAC GLLGVILMVFGFTYQHSIIDLRNIPIMIAALYGGWVSTATALAMITAGRLLITMNTSA LYSVIIICIAAIPSLIVSRRKKVQLKHAFYLLIITNSLISFSFYFLIDLHSYELHLYF WIISIAGGMLSLYIIDHETNAHLLFKQYKFQAHFDFLTGVYNRRKFEETTKALYQQAA DTPHFQFALIYMDIDHFKTINDQYGHHEGDQVLKELGLRLKQTIRNTDPAARIGGEEF AVLLPNCSLDKAARIAERIRSTVSDAPIVLTNGDELSVTISLGAAHYPNNTEQPGSLP ILADQMLYKAKETGRNRVCFSEKKE*" gene complement(985734..986813) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" promotor_-10 complement(986823..986842) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-10" upshifts complement(986844) /Source="Nicolas_upshifts" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" promotor_-35 complement(986858..986862) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-35" promotor_-35 986920..986927 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 986941..986960 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 986947 /Source="Nicolas_upshifts" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" CDS 986986..988377 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12193636, 15262924, 15849754, 16513748, 16850406, 19508281" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 15262924, 15849754, 16513748, 16850406, 19508281; Product type t : transporter" /codon_start=1 /transl_table=11 /product="(sodium)-cystine symporter" /protein_id="NP_388794.1" /db_xref="EnsemblGenomes-Gn:BSU09130" /db_xref="EnsemblGenomes-Tr:CAB12741" /db_xref="GOA:P54596" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11590" /db_xref="UniProtKB/Swiss-Prot:P54596" /translation="METLLVVLHVFILFLLILGLFVMQKKHVSFSKRVFTALGLGIVF GFALQLIYGPTSNIVIQTADWFNIAGGGYVKLLQMVVMPLVFISILGAFTKLKLTKNL GKISGLIIGILVATTAVAAAVGIASALSFDLQAIQVDQGSTELSRGQELQQKSEDMTA KTLPQQIVELLPGNPFLDFTGARPTSTIAVVIFAAFLGVAFLGVKHKQPEQAETFKKL VDAVYAIVMRVVTLILRLTPYGVLAIMTKTIATSDLDSILKLGMFVIASYAALITMFI IHLLLLTFSGLNPVIYLKKAVPVLVFAFTSRSSAGALPLNIKTQRSMGVPEGIANFAG SFGLSIGQNGCAGIYPAMLAMMIAPTVGQNPFDPVFIITVIAVVAISSFGVAGVGGGA TFAALLVLSSLNMPVALAGLLISIEPLIDMGRTALNVSGSMTSGLITSKVTKEIDQGA FHDQSRVIEAEEA*" gene 986986..988377 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" S_feature complement(988013..988416) /Source="Nicolas_S_feature" /locus_tag="new_988013_988416_c" /HighExp="S8, S6, Etha, S5, S7, S4, ferm, nit, Salt, S3" /AntisenseName="tcyP" /AntisenseCor="-0.40132140065468203" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S318" downshifts 988356 /Source="Nicolas_upshifts" /id="D471" /incds=0 /nref=58 /ntot=164 /MaxReadThrough="2.37899" /MaxDrop="5.34563" /score="19.9118074" /energy="-12.8" /TU="NA" /idTUdmin="U713" /TUdmin="-21" /isTUend="TRUE" CDS complement(988417..988872) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21625606" /codon_start=1 /transl_table=11 /product="expressed protein of unknown function" /protein_id="NP_388795.1" /db_xref="EnsemblGenomes-Gn:BSU09140" /db_xref="EnsemblGenomes-Tr:CAB12742" /db_xref="SubtiList:BG11591" /db_xref="UniProtKB/Swiss-Prot:P54597" /translation="MLFNQRRGISPAALIIGSTMLITALSPQIRQRISGFITGQMNRR NSENNTFDASNVGNMVKQAFSGSSGSSGDNQDRSQHQSQRQNGRQHQHAGQQQPQHQH TQSQTRQTETAAKKRQPHYAEPIHFEQNAMNVMDDNTMMEMLEDLEPGR*" gene complement(988417..988872) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" promotor_-10 complement(988887..988905) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(988915) /Source="Nicolas_upshifts" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" promotor_-35 complement(988920..988926) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 988964..988970 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 988984..988995 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 988988 /Source="Nicolas_upshifts" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" CDS 989022..989591 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9611260, 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_388796.2" /db_xref="EnsemblGenomes-Gn:BSU09150" /db_xref="EnsemblGenomes-Tr:CAB12743" /db_xref="GOA:P54598" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG11592" /db_xref="UniProtKB/Swiss-Prot:P54598" /translation="MFGKKQVLASVLLIPLLMTGCGVADQGEGRRDNNDVRNVNYRNP ANDDMRNVNNRDNVDNNVNDNVNNNRVNDDNNNDRKLEVADEAADKVTDLKEVKHADI IVAGNQAYVAVVLTNGNKGAVENNLKKKIAKKVRSTDKNIDNVYVSANPDFVERMQGY GKRIQNGDPIAGLFDEFTQTVQRVFPNAE*" gene 989022..989591 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" promotor_-35 989218..989224 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 989235 /Source="Nicolas_upshifts" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 989238..989249 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 989566 /Source="Nicolas_upshifts" /id="D472" /incds=0 /nref=26 /ntot=183 /MaxReadThrough="1.84697" /MaxDrop="7.80159" /score="33.0647397" /energy="-12.9" /TU="NA" /idTUdmin="U715" /TUdmin="-21" /isTUend="TRUE" promotor_-35 989634..989643 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 989657..989676 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 989667 /Source="Nicolas_upshifts" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" CDS 989712..990680 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein (sporulation germination island)" /protein_id="NP_388797.2" /db_xref="EnsemblGenomes-Gn:BSU09165" /db_xref="EnsemblGenomes-Tr:CAB12744" /db_xref="SubtiList:BG11593" /db_xref="UniProtKB/Swiss-Prot:P54599" /translation="MRDGIGKRAASALFLCGVLVMLAVSSAIVSSAMYILSFPGQASG ITKEQVTKHMKKESFKQADIYYTSKEKSLLPLTKETLEYAVSINQIMIGYSNQKPIDI IFFPNEKQMEAYSGLLDVVGFYSEREQLIGLLPEEKKKLLEGDEVAVYLYQRLLIHEY SHHAFHQKLKELETDPDEFPLWFHEGLSEWIANYELLIDPITFSVVPFDRLQTDRDWQ EARAEYDTDVYLQSFYMIDELTDKYGKDIISEMIKETAKKGDFEKGFKSATKESLDQF EKDFKKKFEKNSAALDSIYPMPLLLVKSLLTHSALCRRHLSLGRGE*" gene 989712..990680 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" downshifts 990556 /Source="Nicolas_upshifts" /id="D473" /incds=1 /nref=28 /ntot=62 /MaxReadThrough="1.51621" /MaxDrop="5.75619" /score="6.21571271" /energy="-16.1" /TU="NA" /idTUdmin="U717" /TUdmin="-1" /isTUend="TRUE" CDS complement(990612..991265) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_388799.1" /db_xref="EnsemblGenomes-Gn:BSU09180" /db_xref="EnsemblGenomes-Tr:CAB12746" /db_xref="GOA:P54601" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG11595" /db_xref="UniProtKB/Swiss-Prot:P54601" /translation="MDQFNQQQQSQMNKGIPGKPHKNHGGHEMFDMHEVLSGTLTVLD QFMMLRQFCKDQELLNILDRQHQFITSQYNITAECFKTGSEPSQKTATYMMKEDNQTV YGMQPSQPKKPVQSMNDIDDSIISRQMLCAIKAQASMLTMASLEMTNPAVRRVLSAQI QEYVEMAFEIFLYQNKHGYYQVPQLDAQDMEQLRNSFAPAQGQMPPTQGGMGQQGLH* " gene complement(990612..991265) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" downshifts complement(990629) /Source="Nicolas_upshifts" /id="D474" /incds=0 /nref=15 /ntot=57 /MaxReadThrough="4.13099" /MaxDrop="4.95733" /score="8.67086892" /energy="-12.9" /TU="U718" /idTUdmin="U718" /TUdmin="-546" /isTUend="FALSE" promotor_-10 complement(991296..991307) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(991298) /Source="Nicolas_upshifts" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" promotor_-35 complement(991322..991328) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 991337..991345 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 991348..995001 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15292138, 21800427, 22020651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292138, 21800427, 22020651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="non specific extracellular Ca2+-dependent endonuclease cleaving RNA and DNA" /protein_id="NP_388800.1" /db_xref="EnsemblGenomes-Gn:BSU09190" /db_xref="EnsemblGenomes-Tr:CAB12747" /db_xref="GOA:P54602" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR019948" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR035437" /db_xref="InterPro:IPR035451" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG11596" /db_xref="UniProtKB/Swiss-Prot:P54602" /translation="MLSVEMISRQNRCHYVYKGGNMMRRILHIVLITALMFLNVMYTF EAVKAAEPQQPISIEKAIQQKEGQALVEGYAVGQAVSPQHYKLTSPFSNDYNVALADR KNKTSPEHILPVQIPSAFRSQFGLQTNPLLLGKKITVQGKLENYFNTTGLKNVQSMNV TDDTKTPPAEQQVTINEARGRLNEEVTIKGIITADQNAIGGGKLSTFLQDETGGINIY SPSPEQFPELKEGMDVTVTGKITSYQGLKEIVPNSSGIKINQSNQSLPAPKHLTINEL INGSLGDQYEGRLVKLTAFVSSIPSSPAGGGYNVTMIDDDHHAMTLRVMNETGVINEL DEGKWYEFTGVLSRYQTFQLLPRKSADLKLLEEQPAPPSAEGEYEGIVDRVVDGDTIH LKSPVLGTTKIRFVNVDAPETYHTPKNDADENQLRFGKKASDYLKTVLSPGDKITVKV GSEAKDSYGRLLGQVITESGSNVNLELVKNGYAPTYFIWPVDNEEDYQQFQAAVAAAK KDQKGIWNENDPLMEMPFEFRAREQGKGLTRYVGDSSNKTYVQPADWKKIAVENRIFF ASASEAESAGYKKRQTAPQEHVPLRILSMNDLHGKIDQQYELDLDGNGTVDGTFGRMD YAAAYLKEKKAEKKNSLIVHAGDMIGGSSPVSSLLQDEPTVELMEDIGFDVGTVGNHE FDEGTDELLRILNGGDHPKGTSGYDGQNFPLVCANCKMKSTGEPFLPAYDIINVEGVP VAFIGVVTQSAAGMVMPEGIKNIEFTDEATAVNKAAEELKKKGVKAIAVLAHMSAEQN GNAITGESADLANKTDSEIDVIFAAHNHQVVNGEVNGKLIVQAFEYGKAIGVVDVEID KTTKDIVKKSAEIVYVDQSKIEPDVSASAILKKYETIAEPIISEVVGEAAVDMEGGYS NDGDTPLGNLIADGMRAAMKTDFALMNGGGIREALKKGPITWGDLYNIQPFGNVLTKL EIKGKDLREIINAQISPVFGPDYSISGFTYTWDKETGKAVDMKMADGTEIQPDATYTL TVNNFMATATGAKYQPIGLLGKNPVTGPEDLEATVEYVKSFDEPIAYTKEGRIKLAEA SDIEDPVTEDPITEEPGDDPGTEDPIKEDPRPGEDLPDIKETPGTAPVHQLPPSAISR FNEIPINNTKTADTANSISTLPLQTETAESGSDHQLPDTSAGYYNFMVIGAAVTLSGT YLYVRRKRSASRT*" gene 991348..995001 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" promotor_-10 991356..991374 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 991371 /Source="Nicolas_upshifts" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" CDS 994998..995594 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" /EC_number="3.4.22.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12823805, 21800427, 22020651, 25038633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12823805, 21800427, 22020651, 25038633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sortase A" /protein_id="NP_388801.1" /db_xref="EnsemblGenomes-Gn:BSU09200" /db_xref="EnsemblGenomes-Tr:CAB12748" /db_xref="GOA:P54603" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG11597" /db_xref="UniProtKB/Swiss-Prot:P54603" /translation="MKKVIPLFIIAAGLVIAGYGGFKLIDTNTKTEQTLKEAKLAAKK PQEASGTKNSTDQAKNKASFKPETGQASGILEIPKINAELPIVEGTDADDLEKGVGHY KDSYYPDENGQIVLSGHRDTVFRRTGELEKGDQLRLLLSYGEFTYEIVKTKIVDKDDT SIITLQHEKEELILTTCYPFSYVGNAPKRYIIYGKRVT*" gene 994998..995594 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" downshifts 995573 /Source="Nicolas_upshifts" /id="D475" /incds=0 /nref=142 /ntot=248 /MaxReadThrough="0.9984" /MaxDrop="5.92245" /score="-4.06268332" /energy="-8.8" /TU="NA" /idTUdmin="U719" /TUdmin=0 /isTUend="TRUE" CDS complement(995624..996532) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" /EC_number="5.4.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9814761, 15044829; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA pseudouridine synthase" /protein_id="NP_388802.2" /db_xref="EnsemblGenomes-Gn:BSU09210" /db_xref="EnsemblGenomes-Tr:CAB12749" /db_xref="GOA:P54604" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11598" /db_xref="UniProtKB/Swiss-Prot:P54604" /translation="MNQKGRGLEILINEKQDGQWLFSVLKTALKASKPVIQDWMSHQQ IKVNHESVLNNMIVKKGDRVFIDLQESEASSVIPEYGELDILFEDNHMLIINKPAGIA THPNEDGQTGTLANLIAYHYQINGETCKVRHVHRLDQDTSGAIVFAKHRLAHAILDQQ LEKKTLKRTYTAIAEGKLRTKKGTINSPIGRDRSHPTRRRVSPGGQTAVTHFKVMASN AKERLSLVELELETGRTHQIRVHLASLGHPLTGDSLYGGGSKLLNRQALHANKVQAVH PITDELIVAEAPFPADMKNLCRTYFS*" gene complement(995624..996532) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" promotor_-35 996588..996596 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(996589..996600) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(996595) /Source="Nicolas_upshifts" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" S_feature complement(996597..997083) /Source="Nicolas_S_feature" /locus_tag="new_996597_997083_c" /HighExp="S8, dia15, Diami, H2O2, G180, G150, dia5, Paraq, Oxctl, S7" /AntisenseName="yhcU" /AntisenseCor="0.69394173601478304" /AntisenseRegPval="-39.200000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S319" upshifts 996607 /Source="Nicolas_upshifts" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" promotor_-10 996610..996629 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(996614..996620) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 996643..997038 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388803.2" /db_xref="EnsemblGenomes-Gn:BSU09220" /db_xref="EnsemblGenomes-Tr:CAB12750" /db_xref="InterPro:IPR020355" /db_xref="SubtiList:BG11599" /db_xref="UniProtKB/Swiss-Prot:P54605" /translation="MARKVIDVRIVNAATAEQESFIKELSMELIHDVFPLYFSELDIQ RFKKKGVLSLNNHYYQGTLKEAFQIMACLQMIHIILTKPSPHSDLSDQAIFEKNSKML NDFGIYFPFAFSDFQKKTNKAFFGQRRLI*" gene 996643..997038 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" misc_feature complement(997069..997088) /Source="Nicolas_upshift_promotors" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(997083) /Source="Nicolas_upshifts" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" promotor_-35 997123..997129 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 997138 /Source="Nicolas_upshifts" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" promotor_-10 997143..997154 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(997153..997167) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(997167) /Source="Nicolas_upshifts" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(997175..997179) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 997175..997597 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CBS containing enzyme (sporulation-/ germination-related)" /protein_id="NP_388804.1" /db_xref="EnsemblGenomes-Gn:BSU09230" /db_xref="EnsemblGenomes-Tr:CAB12751" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG11600" /db_xref="UniProtKB/Swiss-Prot:P54606" /translation="MSSVKDTMTTQVATVSPNQTIQEAASLMKQHNVGAIPVVEQGVL KGMLTDRDIALRTTAQGRDGQTPVSEVMSTELVSGNPNMSLEDASQLMAQHQIRRLPI VDQNNLVGIVALGDLAVNQMSNESAGSALTNISHQNIH*" gene 997175..997597 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" promotor_no_box complement(997501..997601) /Source="Nicolas_upshift_promotors" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(997541) /Source="Nicolas_upshifts" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 997575 /Source="Nicolas_upshifts" /id="D476" /incds=0 /nref=50 /ntot=61 /MaxReadThrough="2.62549" /MaxDrop="7.03747" /score="-2.59023198" /energy="-12.1" /TU="NA" /idTUdmin="U723" /TUdmin=0 /isTUend="TRUE" downshifts complement(997607) /Source="Nicolas_upshifts" /id="D477" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="0.0992700000000006" /MaxDrop="3.96142" /score="-9.32793172" /energy="-9.1" /TU="NA" /idTUdmin="U724" /TUdmin="-506" /isTUend="FALSE" promotor_-35 997647..997654 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 997668..997687 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 997676 /Source="Nicolas_upshifts" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" CDS 997724..998386 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" /EC_number="3.1.3.18" /EC_number="3.1.3.68" /EC_number="3.1.3.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16990279, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphoglycolate phosphatase / glycerol-3-phosphate phosphatase / 2-deoxyglucose-6-phosphatase" /protein_id="NP_388805.1" /db_xref="EnsemblGenomes-Gn:BSU09240" /db_xref="EnsemblGenomes-Tr:CAB12752" /db_xref="GOA:P54607" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11601" /db_xref="UniProtKB/Swiss-Prot:P54607" /translation="MIKALIFDFDGLILDTETHEYEVLQEIFEEHGSVLPLSVWGKVI GTAAGFRPFEYLEEQIGKKLNHEELTQLRRERFAKRMESEKARPGVEAYLNAAKDLGL KIGLASSSDYKWVSGHLKQIGLFDDFEVIQTADDVEEVKPNPELYLLAAKNLGVSPAE CLAFEDSVNGSIAAKRAGMKCVIVPNKVTGTLMFEDYDHRLESMAEMELALLLDHLNS QN*" gene 997724..998386 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" CDS 998402..999943 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" /EC_number="3.5.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26337367, 26808445, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388806.2" /db_xref="EnsemblGenomes-Gn:BSU09250" /db_xref="EnsemblGenomes-Tr:CAB12753" /db_xref="GOA:P54608" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR001110" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG11602" /db_xref="UniProtKB/Swiss-Prot:P54608" /translation="MSEKLDLTRFEKKMVIRNIEEKDIDKIIDLQKDCFPGMEPWKRE HLISHLEHFPEGQFCAEFEGEIIGSCSSLLINFDEYDDRHTWQDITDDGYITNHNPDG LNMYGIEVMVHPKYRRMKIGHRLYEARKDLARRLNLKSIIIGGRIPNYHKYAEEMTAR EYVEQVTRHQIYDPVLSFQLMNGFTLMRINPNYLPDDTASIKYATLMEWNNVDYLPQQ TKRYYKSAFPVRICVIQYEMKKIYSFEEFANQVEYYVDVASDARSDFAVFPEIFTTQL MSFLEERSPSLAVQRITEYTEDYISLFTDLAVKYNVNIIGGSHFVEEEGKIYNIAYLF RRDGTIEKQYKLHITPNERKWWGISAGDQVRVFDTDCGKIAIQICYDIEFPELARIAA DKGAKIIFTPFCTEDRQGYLRVRYCSQARAVENQIYTVISGTVGNLPQTENMDIQYAQ SGIFAPSDFEFARDGIVGETNPNIEMVVIGDVDLEILRRQRQNGTVRQLKDRRRDIYH IQYKK*" gene 998402..999943 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" downshifts 999926 /Source="Nicolas_upshifts" /id="D478" /incds=0 /nref=57 /ntot=238 /MaxReadThrough="4.24486" /MaxDrop="5.06754" /score="24.7413026" /energy="-10.5" /TU="U726" /idTUdmin="U726" /TUdmin="-224" /isTUend="FALSE" CDS 1000027..1000218 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52585.1" /translation="MYSGCALWSFCIFAISYIIQKTARLHIAIAMAVQVVSSATFIST MLSIVTLPVLLWKLHPLSS*" gene 1000027..1000218 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /pseudo promotor_-35 1000249..1000256 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-35" promotor_-10 1000271..1000290 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-10" S_feature 1000282..1000363 /Source="Nicolas_S_feature" /locus_tag="new_1000282_1000363" /HighExp="M40t90, M0t90, T0.30H, LBGstat, BC, Lbstat, M9-stat, Lbtran, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S320" upshifts 1000282 /Source="Nicolas_upshifts" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" CDS 1000364..1001716 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11082195, 23610425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminotransferase" /protein_id="NP_388807.2" /db_xref="EnsemblGenomes-Gn:BSU09260" /db_xref="EnsemblGenomes-Tr:CAB12754" /db_xref="GOA:P33189" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10184" /db_xref="UniProtKB/Swiss-Prot:P33189" /translation="MEMMGMENIQQNQGLKQKDEQFVWHAMKGAHQADSLIAQKAEGA WVTDTDGRRYLDAMSGLWCVNIGYGRKELAEAAYEQLKELPYYPLTQSHAPAIQLAEK LNEWLGGDYVIFFSNSGSEANETAFKIARQYHLQNGDHSRYKFISRYRAYHGNTLGAL SATGQAQRKYKYEPLSQGFLHAAPPDIYRNPDDADTLESANEIDRIMTWELSETIAGV IMEPIITGGGILMPPDGYMKKVEDICRRHGALLICDEVICGFGRTGEPFGFMHYGVKP DIITMAKGITSAYLPLSATAVKRDIFEAYQGEAPYDRFRHVNTFGGSPAACALALKNL QIMEDEQLIQRSRDLGAKLLGELQALREHPAVGDVRGKGLLIGIELVKDKLTKEPADA AKVNQVVAACKEKGLIIGKNGDTVAGYNNVIQLAPPFCLTEEDLSFIVKTVKESFQTI *" gene 1000364..1001716 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" CDS 1001744..1002322 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11929549, 23610425, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 23610425, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate responding transcriptionantiterminator" /protein_id="NP_388808.1" /db_xref="EnsemblGenomes-Gn:BSU09270" /db_xref="EnsemblGenomes-Tr:CAB12755" /db_xref="GOA:P30300" /db_xref="InterPro:IPR006699" /db_xref="InterPro:IPR035928" /db_xref="SubtiList:BG10185" /db_xref="UniProtKB/Swiss-Prot:P30300" /translation="MMSFHNQPILPAIRNMKQFDEFLNSSFSYGVILDIHLGQLKGVI KEAQKHGKNMMVHVDLIQGIKHDEYGAEFICQDIKPAGIISTRSNVIAKAKQKKIYAI QRLFLLDTSAMEKSMEFIGKHKPDFIEVLPGIVPSLIQEIKEKTGIPIFAGGFIRTEE DVEQALKAGAVAVTTSNTKLWKKYENFLTESD*" gene 1001744..1002322 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" promotor_-35 1002317..1002324 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1002339..1002358 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1002350 /Source="Nicolas_upshifts" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" downshifts 1002365 /Source="Nicolas_upshifts" /id="D479" /incds=0 /nref=3 /ntot=39 /MaxReadThrough="8.20986" /MaxDrop="2.99328" /score="6.07464219" /energy="-10" /TU="U727,U728" /idTUdmin="U726" /TUdmin=2215 /isTUend="FALSE" S_feature 1002410..1002500 /Source="Nicolas_S_feature" /locus_tag="new_1002410_1002500" /HighExp="Diami, T0.30H, G150, Oxctl, Gly, Paraq, dia5, BC, B60, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S321" CDS 1002501..1003325 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycerol permease" /protein_id="NP_388809.1" /db_xref="EnsemblGenomes-Gn:BSU09280" /db_xref="EnsemblGenomes-Tr:CAB12756" /db_xref="GOA:P18156" /db_xref="InterPro:IPR000425" /db_xref="InterPro:IPR022357" /db_xref="InterPro:IPR023271" /db_xref="SubtiList:BG10186" /db_xref="UniProtKB/Swiss-Prot:P18156" /translation="MTAFWGEVIGTMLLIIFGAGVCAGVNLKKSLSFQSGWIVVVFGW GLGVAMAAYAVGGISGAHLNPALTIALAFVGDFPWKEVPVYIAAQMIGAIIGAVIIYL HYLPHWKSTDDPAAKLGVFSTGPSIPHTFANVLSEVIGTFVLVLGILAIGANQFTEGL NPLIVGFLIVAIGISLGGTTGYAINPARDLGPRIAHAFLPIPGKGSSNWKYAWVPVVG PILGGSFGGVFYNAAFKGHITSSFWIVSVILVVVLLGLYVYTKSHSAKTLSNSKYI*" gene 1002501..1003325 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" CDS 1003344..1004834 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" /EC_number="2.7.1.30" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9972264, 10920256, 11929549, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol kinase (sn-glycerol-3-phosphate generating)" /protein_id="NP_388810.2" /db_xref="EnsemblGenomes-Gn:BSU09290" /db_xref="EnsemblGenomes-Tr:CAB12757" /db_xref="GOA:P18157" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005999" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10187" /db_xref="UniProtKB/Swiss-Prot:P18157" /translation="METYILSLDQGTTSSRAILFNKEGKIVHSAQKEFTQYFPHPGWV EHNANEIWGSVLAVIASVISESGISASQIAGIGITNQRETTVVWDKDTGSPVYNAIVW QSRQTSGICEELREKGYNDKFREKTGLLIDPYFSGTKVKWILDNVEGAREKAEKGELL FGTIDTWLIWKMSGGKAHVTDYSNASRTLMFNIYDLKWDDELLDILGVPKSMLPEVKP SSHVYAETVDYHFFGKNIPIAGAAGDQQSALFGQACFEEGMGKNTYGTGCFMLMNTGE KAIKSEHGLLTTIAWGIDGKVNYALEGSIFVAGSAIQWLRDGLRMFQDSSLSESYAEK VDSTDGVYVVPAFVGLGTPYWDSDVRGSVFGLTRGTTKEHFIRATLESLAYQTKDVLD AMEADSNISLKTLRVDGGAVKNNFLMQFQGDLLNVPVERPEINETTALGAAYLAGIAV GFWKDRSEIANQWNLDKRFEPELEEEKRNELYKGWQKAVKAAMAFK*" gene 1003344..1004834 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" promotor_-35 1004145..1004151 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 1004166..1004185 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-10" upshifts 1004176 /Source="Nicolas_upshifts" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" S_feature 1004835..1004923 /Source="Nicolas_S_feature" /locus_tag="new_1004835_1004923" /HighExp="Sw, Etha, Salt, G150, Gly, Diami, T0.30H, B60, BC, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S322" downshifts 1004880 /Source="Nicolas_upshifts" /id="D480" /incds=0 /nref=34 /ntot=91 /MaxReadThrough="7.63856" /MaxDrop="5.2045" /score="21.1943866" /energy="-28.7" /TU="U728,U729" /idTUdmin="U727" /TUdmin=0 /isTUend="TRUE" promotor_no_box 1004886..1004986 /Source="Nicolas_upshift_promotors" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1004946 /Source="Nicolas_upshifts" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" CDS 1004975..1006642 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" /EC_number="1.1.3.21" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2127799, 8825777, 9595668, 10633102, 18946204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2127799, 8825777, 9595668, 10633102, 18946204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate oxidase (FAD-dependent)" /protein_id="NP_388811.2" /db_xref="EnsemblGenomes-Gn:BSU09300" /db_xref="EnsemblGenomes-Tr:CAB12758" /db_xref="GOA:P18158" /db_xref="InterPro:IPR000447" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR031656" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10188" /db_xref="UniProtKB/Swiss-Prot:P18158" /translation="MMNHQFSSLERDRMLTDMTKKTYDLFIIGGGITGAGTALDAASR GMKVALSEMQDFAAGTSSRSTKLVHGGLRYLKQFEVKMVAEVGKERAIVYENGPHVTT PEWMLLPFHKGGTFGSFTTSIGLRVYDFLAGVKKSERRSMLSAKETLQKEPLVKKDGL KGGGYYVEYRTDDARLTIEVMKEAVKFGAEPVNYSKVKELLYEKGKAVGVLIEDVLTK KEYKVYAKKIVNATGPWVDQLREKDHSKNGKHLQHTKGIHLVFDQSVFPLKQAVYFDT PDGRMVFAIPREGKTYVGTTDTVYKEALEHPRMTTEDRDYVIKSINYMFPELNITAND IESSWAGLRPLIHEEGKDPSEISRKDEIWTSDSGLITIAGGKLTGYRKMAEHIVDLVR DRLKEEGEKDFGPCKTKNMPISGGHVGGSKNLMSFVTAKTKEGIAAGLSEKDAKQLAI RYGSNVDRVFDRVEALKDEAAKRNIPVHILAEAEYSIEEEMTATPADFFVRRTGRLFF DINWVRTYKDAVIDFMSERFQWDEQAKNKHTENLNKLLHDAVVPLEQ*" gene 1004975..1006642 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" promotor_-35 1006404..1006409 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 1006424..1006442 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-10" upshifts 1006433 /Source="Nicolas_upshifts" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" promotor_-35 1006487..1006493 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1006508 /Source="Nicolas_upshifts" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" promotor_-10 1006509..1006527 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1006610 /Source="Nicolas_upshifts" /id="D481" /incds=0 /nref=13 /ntot=60 /MaxReadThrough="6.57605" /MaxDrop="4.31183" /score="11.5542287" /energy="-11.4" /TU="U728,U729,U730,U731,U732" /idTUdmin="U729" /TUdmin="-118" /isTUend="FALSE" S_feature 1006655..1006728 /Source="Nicolas_S_feature" /locus_tag="new_1006655_1006728" /HighExp="G150, Etha, Oxctl, H2O2, Gly, Diami, Paraq, Salt, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF, Sig-, SigB, SigA" /TUshortPSig="1, 0.995, 0.155, 1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S323" promotor_-35 1006710..1006717 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1006730 /Source="Nicolas_upshifts" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" promotor_-10 1006731..1006750 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1006774..1008519 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" /EC_number="5.4.2.2" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15640167, 17662947, 24097947, 26735940, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15640167, 17662947, 24097947, 26735940, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-phosphoglucomutase" /protein_id="NP_388812.2" /db_xref="EnsemblGenomes-Gn:BSU09310" /db_xref="EnsemblGenomes-Tr:CAB12759" /db_xref="GOA:P18159" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG10189" /db_xref="UniProtKB/Swiss-Prot:P18159" /translation="MTWRKSYERWKQTEHLDLELKERLIELEGDEQALEDCFYKDLEF GTGGMRGEIGAGTNRMNIYTVRKASAGFAAYISKQGEEAKKRGVVIAYDSRHKSPEFA MEAAKTLATQGIQTYVFDELRPTPELSFAVRQLNAYGGIVVTASHNPPEYNGYKVYGD DGGQLPPKEADIVIEQVNAIENELTITVDEENKLKEKGLIKIIGEDIDKVYTEKLTSI SVHPELSEEVDVKVVFTPLHGTANKPVRRGLEALGYKNVTVVKEQELPDSNFSTVTSP NPEEHAAFEYAIKLGEEQNADILIATDPDADRLGIAVKNDQGKYTVLTGNQTGALLLH YLLSEKKKQGILPDNGVVLKTIVTSEIGRAVASSFGLDTIDTLTGFKFIGEKIKEYEA SGQYTFQFGYEESYGYLIGDFARDKDAIQAALLAVEVCAFYKKQGMSLYEALINLFNE YGFYREGLKSLTLKGKQGAEQIEAILASFRQNPPQKMAGKQVVTAEDYAVSKRTLLTE SKEEAIDLPKSNVLKYFLEDGSWFCLRPSGTEPKVKFYFAVKGSSLEDSEKRLAVLSE DVMKTVDEIVESTAK*" gene 1006774..1008519 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" downshifts 1008508 /Source="Nicolas_upshifts" /id="D482" /incds=0 /nref=227 /ntot=264 /MaxReadThrough="4.80136" /MaxDrop="5.89896" /score="26.7163878" /energy="-13" /TU="U732,U733" /idTUdmin="U728" /TUdmin="-6" /isTUend="TRUE" S_feature 1008553..1008622 /Source="Nicolas_S_feature" /locus_tag="new_1008553_1008622" /HighExp="Etha, H2O2, B36, dia15, Paraq, G150, LoTm, S8, Oxctl, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S324" misc_feature 1008624..1008643 /Source="Nicolas_upshift_promotors" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1008624 /Source="Nicolas_upshifts" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" CDS 1008668..1009807 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YhcZ]" /protein_id="NP_388813.1" /db_xref="EnsemblGenomes-Gn:BSU09320" /db_xref="EnsemblGenomes-Tr:CAB12760" /db_xref="GOA:O07527" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13005" /db_xref="UniProtKB/Swiss-Prot:O07527" /translation="MSKTRMEKLKTLKTIAETLNQGHDIKATLDEVLKELLSLTNLQS GWIFLIEEDGSYTLAADAYLPPALSRKEKVLMCEGECYCLTKFNNGGLRKAANIMNCK RIESAENLHCFDTEGITHHATVPLEDGDRRFGLLNVAAAGKTMFDEEELHLLESVAFQ IGTAIQRMRLSEYQQKNALLMERNRLAQELHDSVNQMLFSVSLTAKAAKTLTKDENLQ QMIDFIQNLSQDALAEMKALIWQLRPGGLEKGLAEAIKSYGALIGLKIIFTQKGCPVL TDEQEHMLWRVVQEALNNCKKHAGTDTAYVSLTASLCHAELDIIDHGAGFRYEAHAGL PSLGIKGMKERAEKAGAKFWIESALGTGTKLSIRLPLKSRKGGAV*" gene 1008668..1009807 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" CDS 1009804..1010448 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YhcY]" /protein_id="NP_388814.1" /db_xref="EnsemblGenomes-Gn:BSU09330" /db_xref="EnsemblGenomes-Tr:CAB12761" /db_xref="GOA:O07528" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13006" /db_xref="UniProtKB/Swiss-Prot:O07528" /translation="MKIVIADDHHVVRKGLRFFFATQDDIEVVGEAATGLEALRVIEE TKPDLVLMDLSMPEMDGIQAIKKAIQQFPDTNIIVLTSYSDQEHVIPALQAGAKAYQL KDTEPEELVKTRQVHGGEYKLSTAIMPHVLTHMKNQHDPEKEKYYQLTRREKDVLTEI ANGKSNKEIAAALFISEKTVKTHVSNLLAKLEVADRTQAALFAVKYNLNGEISK*" gene 1009804..1010448 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" CDS 1010445..1010969 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" /EC_number="1.7.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15184374, 16816187, 20639339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidoreductase, NAD(P)H-FMN and ferric iron reductase (azoreductase)" /protein_id="NP_388815.1" /db_xref="EnsemblGenomes-Gn:BSU09340" /db_xref="EnsemblGenomes-Tr:CAB12762" /db_xref="GOA:O07529" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1NNI" /db_xref="PDB:2GSW" /db_xref="PDB:3GFQ" /db_xref="PDB:3GFR" /db_xref="PDB:3GFS" /db_xref="SubtiList:BG13007" /db_xref="UniProtKB/Swiss-Prot:O07529" /translation="MNMLVINGTPRKHGRTRIAASYIAALYHTDLIDLSEFVLPVFNG EAEQSELLKVQELKQRVTKADAIVLLSPEYHSGMSGALKNALDFLSSEQFKYKPVALL AVAGGGKGGINALNNMRTVMRGVYANVIPKQLVLDPVHIDVENATVAENIKESIKELV EELSMFAKAGNPGV*" gene 1010445..1010969 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" downshifts 1010934 /Source="Nicolas_upshifts" /id="D483" /incds=0 /nref=72 /ntot=215 /MaxReadThrough="2.90096" /MaxDrop="4.78561" /score="27.1269177" /energy="-17.2" /TU="NA" /idTUdmin="U734" /TUdmin=0 /isTUend="TRUE" CDS complement(1010984..1011226) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388816.1" /db_xref="EnsemblGenomes-Gn:BSU09350" /db_xref="EnsemblGenomes-Tr:CAB12763" /db_xref="InterPro:IPR025431" /db_xref="SubtiList:BG13008" /db_xref="UniProtKB/Swiss-Prot:O07530" /translation="MDYADYDKALYYTHRSQWDNLLILMVRTEDDLLSKRIEHFLHAY HFEQDYAVLEKMLYSLLRYIDHATELTYEDQIALLT*" gene complement(1010984..1011226) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" downshifts complement(1011005) /Source="Nicolas_upshifts" /id="D484" /incds=0 /nref=39 /ntot=84 /MaxReadThrough="-0.0235599999999998" /MaxDrop="7.78706" /score="12.0066876" /energy="-17.2" /TU="NA" /idTUdmin="U735" /TUdmin="-17" /isTUend="TRUE" promotor_-10 complement(1011262..1011273) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1011273) /Source="Nicolas_upshifts" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" promotor_-35 complement(1011287..1011294) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1011361..1011367 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1011381..1011392 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1011391 /Source="Nicolas_upshifts" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" CDS 1011427..1011750 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388817.1" /db_xref="EnsemblGenomes-Gn:BSU09360" /db_xref="EnsemblGenomes-Tr:CAB12764" /db_xref="InterPro:IPR024987" /db_xref="SubtiList:BG13009" /db_xref="UniProtKB/Swiss-Prot:O07531" /translation="MKSLPYTIALLFCGLIIVSMAAKGHSTDTDESVQKWEQLAWSKI QDEYKGASFSDYAYMGRTEVNDQQTKDVFRVTVRQKDDTFSVRAEVYFHPVTNHMISI NVFRL*" gene 1011427..1011750 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" S_feature 1011751..1013617 /Source="Nicolas_S_feature" /locus_tag="new_1011751_1013617" /HighExp="S8, S5, S7, S6, S4, C30, Sw, ferm, S3, BC" /AntisenseName="lytF" /AntisenseCor="-0.65564579825076796" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S325" CDS complement(1011792..1013258) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10206711, 14594841, 18761694, 18761696, 23091053, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10206711, 14594841, 18761694, 18761696, 23091053, 25288647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamate-meso-diaminopimelate muropeptidase (major autolysin, vegetative)" /protein_id="NP_388818.2" /db_xref="EnsemblGenomes-Gn:BSU09370" /db_xref="EnsemblGenomes-Tr:CAB12776" /db_xref="GOA:O07532" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13010" /db_xref="UniProtKB/Swiss-Prot:O07532" /translation="MKKKLAAGLTASAIVGTTLVVTPAEAATIKVKSGDSLWKLAQTY NTSVAALTSANHLSTTVLSIGQTLTIPGSKSSTSSSTSSSTTKKSGSSVYTVKSGDSL WLIANEFKMTVQELKKLNGLSSDLIRAGQKLKVSGTVSSSSSSSKKSNSNKSSSSSSK SSSNKSSSSSSSTGTYKVQLGDSLWKIANKVNMSIAELKVLNNLKSDTIYVNQVLKTK SSGSDTSSKDNSSKSNQTSATTKYTVKSGDSLWKIANNYNLTVQQIRNINNLKSDVLY VGQVLKLTGKASSGSSSSSSSSSNASSGTTTTYTVKSGDSLWVIAQKFNVTAQQIREK NNLKTDVLQVGQKLVISGKASSSSSSGSSNTTSSTSAKINTMISAAKAQLGVPYRWGG TTPSGFDCSGFIYYVLNKVTSVSRLTAAGYWNTMKSVSQPAVGDFVFFSTYKAGPSHV GIYLGNGEFINANDSGVVISNMNNSYWKQRYLGAKRYF*" gene complement(1011792..1013258) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" downshifts complement(1011804) /Source="Nicolas_upshifts" /id="D485" /incds=0 /nref=121 /ntot=216 /MaxReadThrough="2.34529" /MaxDrop="4.33563" /score="24.6732339" /energy="-14.2" /TU="NA" /idTUdmin="U737" /TUdmin="-1" /isTUend="TRUE" downshifts complement(1011891) /Source="Nicolas_upshifts" /id="D486" /incds=1 /nref=1 /ntot=87 /MaxReadThrough="5.73069" /MaxDrop="2.6306" /score="24.6732339" /energy="-14.2" /TU="U737" /idTUdmin="U737" /TUdmin="-88" /isTUend="FALSE" promotor_-10 complement(1013298..1013316) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1013310) /Source="Nicolas_upshifts" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" promotor_-35 complement(1013330..1013337) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1013411..1013851) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033; Product type r: regulator" /codon_start=1 /transl_table=11 /product="NO-dependent activator of the ResDE regulon (Fe-S NO binding site)" /protein_id="NP_388819.1" /db_xref="EnsemblGenomes-Gn:BSU09380" /db_xref="EnsemblGenomes-Tr:CAB12777" /db_xref="GOA:O07573" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13011" /db_xref="UniProtKB/Swiss-Prot:O07573" /translation="MKLTNYTDYSLRVLIFLAAERPGELSNIKQIAETYSISKNHLMK VIYRLGQLGYVETIRGRGGGIRLGMDPEDINIGEVVRKTEDDFNIVECFDANKNLCVI SPVCGLKHVLNEALLAYLAVLDKYTLRDLVKNKEDIMKLLKMKE*" gene complement(1013411..1013851) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" downshifts complement(1013441) /Source="Nicolas_upshifts" /id="D487" /incds=0 /nref=205 /ntot=265 /MaxReadThrough="3.11158" /MaxDrop="6.87147" /score="5.96186156" /energy="-7.8" /TU="U739" /idTUdmin="U740" /TUdmin="-10" /isTUend="TRUE" promotor_-35 1013839..1013845 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1013859..1013870 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1013861..1013971 /Source="Nicolas_S_feature" /locus_tag="new_1013861_1013971" /HighExp="S8, S7, S4, Sw, S5, S6, BC, B60, nit, Pyr" /AntisenseName="ygxB" /AntisenseCor="-0.211236686077168" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.904" /TUlongSig="NA" /TUlongPSig="NA" /label="S326" upshifts 1013861 /Source="Nicolas_upshifts" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" promotor_-10 complement(1013873..1013892) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1013889) /Source="Nicolas_upshifts" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" promotor_-35 complement(1013904..1013910) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1013930 /Source="Nicolas_upshifts" /id="D488" /incds=0 /nref=10 /ntot=68 /MaxReadThrough="1.05981" /MaxDrop="6.25571" /score="22.5171081" /energy="-11.6" /TU="NA" /idTUdmin="U738" /TUdmin=3 /isTUend="TRUE" CDS complement(1013958..1015616) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388820.1" /db_xref="EnsemblGenomes-Gn:BSU09390" /db_xref="EnsemblGenomes-Tr:CAB12778" /db_xref="GOA:P37874" /db_xref="InterPro:IPR008910" /db_xref="SubtiList:BG10181" /db_xref="UniProtKB/Swiss-Prot:P37874" /translation="MYEPARQKMIVSLGQEKIPPAHSSVCLLDKWVNTHHTTKKERYQ LNVADVFSSYLSKLPNVIIALLVLLIGWAIAKIIEKAVYKGLSKTKIDDKLFAGKKPS RYSSEKVISKVVYFIALIIVFILFFNILHLTTVASPFVSMLSAIAAAIPSVLKAGLIL LLGWAAASVLSFLVKKIGMKLNTSDKLRKWNLVSEGKDIHQAVNTASQIVFYLVLLVF LPGVLSSLKISGISGPFTNMMESVLAFLPKLFAAALIVLIGWLVARLVRDIITNFLAS IGTERFAARMGLSIYLKDTSLSAVIGTIAYVLIMIPVVISALDQLDVAGISKPAVSML NTILNMLPNIMIAIVLVLAGIWAGKWVKSMVSGLLHRAGFDSVLGKMGMEAGTPAKLS LSQVVGMIAQIIVILLFTAEALQIVRLHFLVEIATGIIAYLPNVLVAVFILGLGLYAG ELVRKVLASMIKGQEFKSLAPIAKYTIIALAFFMALDQLGVAATIVNSAFIIVLSGFA LAFGLSFGLGGKDFASRYLSTFERKMQNTEIEKNRKNQNPPNDM*" gene complement(1013958..1015616) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" downshifts complement(1013963) /Source="Nicolas_upshifts" /id="D489" /incds=0 /nref=6 /ntot=40 /MaxReadThrough="8.34865" /MaxDrop="5.55332" /score="-5.46969987" /energy="-14.5" /TU="U740" /idTUdmin="U740" /TUdmin="-532" /isTUend="FALSE" promotor_-10 complement(1015507..1015525) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1015527) /Source="Nicolas_upshifts" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" promotor_-35 complement(1015539..1015545) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1015588..1015593 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1015609..1015627 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1015622 /Source="Nicolas_upshifts" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" CDS 1015647..1017053 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8144469, 14680823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8144469, 14680823; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation, conserved in non sporulating bacteria" /protein_id="NP_388821.1" /db_xref="EnsemblGenomes-Gn:BSU09400" /db_xref="EnsemblGenomes-Tr:CAB12779" /db_xref="GOA:P37875" /db_xref="InterPro:IPR007390" /db_xref="SubtiList:BG10182" /db_xref="UniProtKB/Swiss-Prot:P37875" /translation="MNAEEKKGLQRAIEEITEIAKGFGLDFYPMRYEICPAEIIYTFG AYGMPTRFSHWSFGKQFHKMKLHYDLGLSKIYELVINSDPCYAFLLDSNSLIQNKLIV AHVLAHCDFFKNNCRFQNTKRDMVESMAATAERIKHYEQVHGIKEVESFLDAILSIQE HIDPSLVRPKLQWSVDDEEEEIEEAATPYDDLWSLDEKKPKKQVKKSKKPFPPRPEKD ILLFIEEHSRELEPWQRDILTMMREEMLYFWPQLETKIMNEGWASYWHQRIIRELDLT SDEAIEFAKLNAGVVQPSKTGINPYYLGLKIFEDIEKRYNNPTEEMKKMGVQPDSGRE KMFEVREIESDISFIRNYLTKELVMREDLYLFQKQGRDYKIIDKQWKSVRDQLVSMRV NGGFPYLTVNDGDYMKNNELYIKHWYEGIELDLKYLEKVLPYLFQLWGRSVHIESVLE DKEVMFSYDGKGVHRRYL*" gene 1015647..1017053 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" downshifts 1017033 /Source="Nicolas_upshifts" /id="D490" /incds=0 /nref=43 /ntot=84 /MaxReadThrough="1.30719" /MaxDrop="6.74388" /score="26.4488835" /energy="-11.5" /TU="NA" /idTUdmin="U741" /TUdmin=0 /isTUend="TRUE" CDS complement(1017083..1018468) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" /EC_number="3.1.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8830275, 10913081, 12897025, 16491025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830275, 10913081, 12897025, 16491025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkaline phosphatase A" /protein_id="NP_388822.2" /db_xref="EnsemblGenomes-Gn:BSU09410" /db_xref="EnsemblGenomes-Tr:CAB12780" /db_xref="GOA:P19406" /db_xref="InterPro:IPR001952" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR018299" /db_xref="SubtiList:BG10183" /db_xref="UniProtKB/Swiss-Prot:P19406" /translation="MKKMSLFQNMKSKLLPIAAVSVLTAGIFAGAELQQTEKASAKKQ DKAEIRNVIVMIGDGMGTPYIRAYRSMKNNGDTPNNPKLTEFDRNLTGMMMTHPDDPD YNITDSAAAGTALATGVKTYNNAIGVDKNGKKVKSVLEEAKQQGKSTGLVATSEINHA TPAAYGAHNESRKNMDQIANSYMDDKIKGKHKIDVLLGGGKSYFNRKDRNLTKEFKQA GYSYVTTKQALKKNKDQQVLGLFADGGLAKALDRDSKTPSLKDMTVSAIDRLNQNKKG FFLMVEGSQIDWAAHDNDTVGAMSEVKDFEQAYKAAIEFAKKDKHTLVIATADHTTGG FTIGANGEKNWHAEPILSAKKTPEFMAKKISEGKPVKDVLARYANLKVTSEEIKSVEA AAQADKSKGASKAIIKIFNTRSNSGWTSTDHTGEEVPVYAYGPGKEKFRGLINNTDQA NIIFKILKTGK*" gene complement(1017083..1018468) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" downshifts complement(1017109) /Source="Nicolas_upshifts" /id="D491" /incds=0 /nref=51 /ntot=178 /MaxReadThrough="1.90638" /MaxDrop="5.795" /score="22.2126775" /energy="-13.2" /TU="NA" /idTUdmin="U742" /TUdmin=0 /isTUend="TRUE" upshifts complement(1018495) /Source="Nicolas_upshifts" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" S_feature complement(1018497..1020028) /Source="Nicolas_S_feature" /locus_tag="new_1018497_1020028_c" /HighExp="Etha, Salt, B60, Heat, M9-stat, T5.0H, T0.30H, T4.0H, T3.30H, T2.30H" /AntisenseName="lytE" /AntisenseCor="-0.65081062481616203" /AntisenseRegPval="-33.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="0.966, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S327" misc_feature complement(1018505..1018516) /Source="Nicolas_upshift_promotors" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1018624..1018631 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1018644..1018663 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1018650..1018937 /Source="Nicolas_S_feature" /locus_tag="new_1018650_1018937" /HighExp="T-5.40H, Cold, LoTm, T-4.40H, UNK1, T5.0H, GM-0.1, T3.30H, S1, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S328" upshifts 1018650 /Source="Nicolas_upshifts" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" promotor_-35 1018900..1018903 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1018918..1018937 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1018939 /Source="Nicolas_upshifts" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" CDS 1018998..1020002 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 16950129, 9457885, 21541672, 22139507, 27002131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 16950129, 9457885, 21541672, 22139507, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cell wall dl-endopeptidase; phosphatase-associated protein (major autolysin)" /protein_id="NP_388823.2" /db_xref="EnsemblGenomes-Gn:BSU09420" /db_xref="EnsemblGenomes-Tr:CAB12781" /db_xref="GOA:P54421" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11406" /db_xref="UniProtKB/Swiss-Prot:P54421" /translation="MKKQIITATTAVVLGSTLFAGAASAQSIKVKKGDTLWDLSRKYD TTISKIKSENHLRSDIIYVGQTLSINGKSTSSKSSSSSSSSSTYKVKSGDSLWKISKK YGMTINELKKLNGLKSDLLRVGQVLKLKGSTSSSSSSSSKVSSSSTSTYKVKSGDSLS KIASKYGTTVSKLKSLNGLKSDVIYVNQVLKVKGTSTSSSKPASSSSSSSSKTSSTSL NVSKLVSDAKALVGTPYKWGGTTTSGFDCSGFIWYVLNKQTSVGRTSTAGYWSSMKSI ASPSVGDFVFFTTYKSGPSHMGIYIGNNSFIHAGSDGVQISSLNNSYWKPRYLGAKRF *" gene 1018998..1020002 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" downshifts 1019864 /Source="Nicolas_upshifts" /id="D492" /incds=1 /nref=1 /ntot=117 /MaxReadThrough="6.89938" /MaxDrop="2.1687" /score="26.3320532" /energy="-9.8" /TU="U743,U744" /idTUdmin="U743" /TUdmin="-132" /isTUend="FALSE" downshifts 1019994 /Source="Nicolas_upshifts" /id="D493" /incds=0 /nref=53 /ntot=190 /MaxReadThrough="3.64545" /MaxDrop="6.08377" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin="-2" /isTUend="TRUE" upshifts complement(1020028) /Source="Nicolas_upshifts" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" promotor_-10 complement(1020035..1020050) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1020040 /Source="Nicolas_upshifts" /id="D494" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="2.99" /MaxDrop="3.76174" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin=44 /isTUend="FALSE" promotor_-35 complement(1020062..1020071) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1020073..1020948) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8045899, 10869065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045899, 10869065; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator CitR (LysR family)" /protein_id="NP_388824.2" /db_xref="EnsemblGenomes-Gn:BSU09430" /db_xref="EnsemblGenomes-Tr:CAB12782" /db_xref="GOA:P39127" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10853" /db_xref="UniProtKB/Swiss-Prot:P39127" /translation="MDFKWLHTFVTAAKYENFRKTAETLFLSQPTVTVHIKQLEKEIS CKLFERKGRQIQLTDEGRAYLPYALRLLDDYENSMAELHRVRQGYSQTLQLAVSPLIA DTVLPSVMKRYTAMNTETEMAVTIFESAEIASLIKAGEADIGLSCLKVQSSSLSCHCL YKDPVVLVAPPDKRFIEDNEIDAKEVLEQYLLLTHNHPDYWDDLLRQVRMTFPFVRTM KVTQTHITKRFIKEGLGVSFLPLSTVKRELAEKQMIRIPYQSVQLPYAGAYAIALYEN KKEKKFLDFLSHFHF*" gene complement(1020073..1020948) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" promotor_-35 1021001..1021002 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1021014..1021033) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-10" promotor_-10 1021019..1021038 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1021020) /Source="Nicolas_upshifts" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" upshifts 1021029 /Source="Nicolas_upshifts" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" promotor_-35 complement(1021048..1021053) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-35" CDS 1021057..1022157 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:4211224, 8045898, 8045899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4211224, 8045898, 8045899; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase I" /protein_id="NP_388825.2" /db_xref="EnsemblGenomes-Gn:BSU09440" /db_xref="EnsemblGenomes-Tr:CAB12783" /db_xref="GOA:P39119" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR016143" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="PDB:2C6X" /db_xref="SubtiList:BG10854" /db_xref="UniProtKB/Swiss-Prot:P39119" /translation="MVHYGLKGITCVETSISHIDGEKGRLIYRGHHAKDIALNHSFEE AAYLILFGKLPSTEELQVFKDKLAAERNLPEHIERLIQSLPNNMDDMSVLRTVVSALG ENTYTFHPKTEEAIRLIAITPSIIAYRKRWTRGEQAIAPSSQYGHVENYYYMLTGEQP SEAKKKALETYMILATEHGMNASTFSARVTLSTESDLVSAVTAALGTMKGPLHGGAPS AVTKMLEDIGEKEHAEAYLKEKLEKGERLMGFGHRVYKTKDPRAEALRQKAEEVAGND RDLDLALHVEAEAIRLLEIYKPGRKLYTNVEFYAAAVMRAIDFDDELFTPTFSASRMV GWCAHVLEQAENNMIFRPSAQYTGAIPEEVLS*" gene 1021057..1022157 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" promotor_-35 1022168..1022174 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1022189..1022207 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1022194 /Source="Nicolas_upshifts" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" CDS 1022231..1023100 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 18643936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)-dependent dehydrogenase" /protein_id="NP_388826.1" /db_xref="EnsemblGenomes-Gn:BSU09450" /db_xref="EnsemblGenomes-Tr:CAB12784" /db_xref="GOA:O07575" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13012" /db_xref="UniProtKB/Swiss-Prot:O07575" /translation="MNPMDRQTEGQEPQHQDRQPGIESKMNPLPLSEDEDYRGSGKLK GKVAIITGGDSGIGRAAAIAFAKEGADISILYLDEHSDAEETRKRIEKENVRCLLIPG DVGDENHCEQAVQQTVDHFGKLDILVNNAAEQHPQDSILNISTEQLEKTFRTNIFSMF HMTKKALPHLQEGCAIINTTSITAYEGDTALIDYSSTKGAIVSFTRSMAKSLADKGIR VNAVAPGPIWTPLIPATFPEEKVKQHGLDTPMGRPGQPVEHAGAYVLLASDESSYMTG QTIHVNGGRFIST*" gene 1022231..1023100 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" downshifts 1023108 /Source="Nicolas_upshifts" /id="D495" /incds=0 /nref=27 /ntot=130 /MaxReadThrough="8.65426" /MaxDrop="6.48064" /score="18.1511963" /energy="-8.2" /TU="U748" /idTUdmin="U747" /TUdmin=9 /isTUend="TRUE" promotor_-35 1023185..1023188 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1023200 /Source="Nicolas_upshifts" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" promotor_-10 1023203..1023222 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 1023248..1023267 /Source="Nicolas_upshift_promotors" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1023253..1023349 /Source="Nicolas_S_feature" /locus_tag="new_1023253_1023349" /HighExp="Etha, T2.30H, T-0.40H, T2.0H, T1.30H, S1, GM-0.2, T3.0H, T-1.40H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.27332800000000002" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.522, 0.998, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S329" upshifts 1023253 /Source="Nicolas_upshifts" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" CDS 1023350..1024747 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16621821, 16850406, 21097623, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16621821, 16850406, 21097623, 25645558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid transporter or methylthioribose-degradation metabolite exporter" /protein_id="NP_388827.1" /db_xref="EnsemblGenomes-Gn:BSU09460" /db_xref="EnsemblGenomes-Tr:CAB12785" /db_xref="GOA:O07576" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004758" /db_xref="SubtiList:BG13013" /db_xref="UniProtKB/Swiss-Prot:O07576" /translation="MKGSVFRKKSIQDLIAATSGEKSLKRELGAFDLTLLGIGAIIGT GIFVLTGTGAVTAGPGLTISFVVAALACLFAALSYAEFASSVPVSGSVYTFTYATLGE LMAFIIGWDLILEYMLAVSAVSVGWSGYFQSFLSGLGIHLPVALTAAPGAVKGTFTLF NLPAFVIVMAITYLLYLGIKESKRVNNIMVILKILVVLLFIAVAAVYVKPHNWQPFMP MGFGGVFSAAALVFFAFIGFDAVSSAAEETKNPAKDLPKGIIFSLLVCTILYVTVSAI MTGVIPFAQFAGVDHPVSLVLQSAGQNWVAGIIDIGAVLGMTTVMLVMLYGQTRVMFA MSRDGLVPGSLSKVHPKHKTPYVATWFFGTMSALLGSLVPLDELAKLVNIGTLSAFVL ISVAVIVLRKKQPDLPRAFKCPGVPVIPGLAILFCLFLILNLGWVTIVRFLVWLLIGL VIYFLYSRKHSKLNQ*" gene 1023350..1024747 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" downshifts 1024727 /Source="Nicolas_upshifts" /id="D496" /incds=0 /nref=116 /ntot=188 /MaxReadThrough="3.41176" /MaxDrop="5.29633" /score="5.08283681" /energy="-12.3" /TU="U748,U749" /idTUdmin="U750" /TUdmin=0 /isTUend="TRUE" promotor_-35 1024808..1024812 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1024828..1024847 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1024835 /Source="Nicolas_upshifts" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" CDS 1024865..1026220 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_388828.1" /db_xref="EnsemblGenomes-Gn:BSU09470" /db_xref="EnsemblGenomes-Tr:CAB12786" /db_xref="GOA:O07577" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13014" /db_xref="UniProtKB/Swiss-Prot:O07577" /translation="MSEQKPVQWASKIGFVMAAAGSAIGLGAIWKFPYVAGTNGGGAF FLIFVLFTILLGYPLLVGEFIFGRRNQTNAIDAYKKEAPRSAWFLTGWIGVAACFLVL SFYSVIGGWILLYIVKTASGSLSGLSQAQYGALFASIIQNPVQTLAAQLVFMALTVLV VARGVQKGIERVSAVMMPILFLLFILLVLRSLTLNGAMEGVKFLLVPHFGDLTPESIL FALGQAFFTLTLGVSVMVTYSSYLPKTQNIPRSAASIVLMNIIVTLLAGLAIFPAVFS FGFQPNEGPTLLFTVLPAVFEQLPFGTLFFIGFLVAFLFAALTSAFSMVEIIVATIGK GDEKKRKKLSWTSGLLIFLVGIPCCLSYGVLSDVHLFGKTFFDIADFTVSNVLMPSGA LLISLFIPLKISKSELLAEMRNGSNAGKAFFYTWFYLLRFIVPLAIIIVFLNLIGILS F*" gene 1024865..1026220 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" downshifts 1026201 /Source="Nicolas_upshifts" /id="D497" /incds=0 /nref=184 /ntot=244 /MaxReadThrough="1.73756" /MaxDrop="6.09379" /score="40.1809389" /energy="-14.8" /TU="NA" /idTUdmin="U751" /TUdmin=0 /isTUend="TRUE" CDS complement(1026255..1027664) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388829.1" /db_xref="EnsemblGenomes-Gn:BSU09480" /db_xref="EnsemblGenomes-Tr:CAB12787" /db_xref="GOA:O07578" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13015" /db_xref="UniProtKB/Swiss-Prot:O07578" /translation="MDITPFLDKKSKTPLYEQLYTFFKQEISHARITKGTRLPSKRRL SSLLDVSTATIERAYEQLTAEGYVKSKPKIGWFAAEVEPGFPTAPDHFQQSVQPGLHQ KNAPAIDFHQGSVDPTLFPFNAWRKSIVKSLDRYSGSFHTSGDPQGEYELRHMIARFV RLSRGVNCEPGQIIIGAGTTVLLQNLCLSLKPGTKIGFEEPGFHRSRRMFEANHMDVT PICSDAEGVLPDELYRQNPYLMYTTPSHQFPIGTIMTITRRQELLAWAAETNSFIIED DYDGEFRYSGHPIPSLQGLDPNGRVIYLGTFSKSLLPSLRLSFMIVPPELMEPIQNNV QLMKQTVSAHSQLALADFIETGEWQKHINRMRSLYRKKHAVLLEAIRSELGNTVEILG KNSGLHILLRLLFPASEEEAIQAAADHGVTLYPVSPSYIEQTPFTSVLIGYGGLSEED IRLGIQKLKTAWAPLISSY*" gene complement(1026255..1027664) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" promotor_-35 1027713..1027716 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1027731..1027750 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1027733 /Source="Nicolas_upshifts" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" promotor_-10 complement(1027735..1027754) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1027747) /Source="Nicolas_upshifts" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" promotor_-35 complement(1027770..1027774) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1027774..1028202 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388830.1" /db_xref="EnsemblGenomes-Gn:BSU09490" /db_xref="EnsemblGenomes-Tr:CAB12788" /db_xref="GOA:O07579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13016" /db_xref="UniProtKB/Swiss-Prot:O07579" /translation="MIHMKQLTSKEEWAESYPIMSELRTELDIETYLQRLEACVQKES YMLFALYENTAIRALCGALPRVSIHKGEHLWIADLVTTAPCRSKGYGKMLLDYASDWA RKAGLGFVSLSSGLQRKDAHRFYTDKMGFTIESYLFRKPV*" gene 1027774..1028202 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" downshifts 1028181 /Source="Nicolas_upshifts" /id="D498" /incds=0 /nref=46 /ntot=213 /MaxReadThrough="1.42962" /MaxDrop="4.77191" /score="24.6412105" /energy="-12.1" /TU="NA" /idTUdmin="U752" /TUdmin=0 /isTUend="TRUE" CDS complement(1028233..1028523) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388831.1" /db_xref="EnsemblGenomes-Gn:BSU09500" /db_xref="EnsemblGenomes-Tr:CAB12789" /db_xref="GOA:O07580" /db_xref="InterPro:IPR020496" /db_xref="SubtiList:BG13017" /db_xref="UniProtKB/Swiss-Prot:O07580" /translation="MELVRIFKEHNVFGWISVGTAVLSLLLLNLAIISNVTFYSYQML PFAMAAVPFGVVELFIKRGRTGPGLLGVILNLFVIICVYTIVSVDTNLQFGF*" gene complement(1028233..1028523) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" downshifts complement(1028257) /Source="Nicolas_upshifts" /id="D499" /incds=0 /nref=44 /ntot=229 /MaxReadThrough="2.66153" /MaxDrop="4.72865" /score="26.7359231" /energy="-11.1" /TU="NA" /idTUdmin="U754" /TUdmin=0 /isTUend="TRUE" CDS complement(1028511..1029587) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388832.1" /db_xref="EnsemblGenomes-Gn:BSU09510" /db_xref="EnsemblGenomes-Tr:CAB12790" /db_xref="GOA:O07581" /db_xref="InterPro:IPR025672" /db_xref="InterPro:IPR029101" /db_xref="SubtiList:BG13018" /db_xref="UniProtKB/Swiss-Prot:O07581" /translation="MMNEEFKKRFDQYKNGEMSDQEMTAFEEELEKLEVYQELIDSEL EDDNDWDLSISPEKQKAILAYGKRKSYLRISVLAVISTLMILPLCTLGSYLYYGMGGK HSTGNEFMETAAVTVALTMPNVLVDTSGLKSQVKLFGMNTEFPLQKQIGTKTAAVGNE RVEMFYNKVKAPAVNYYDLEVNKTGHYFTHPSNKSEQTTAKAEKTLSTLPEGTVSEVY LSYDRAYPTKDVYNKFKGYDVSFLWNAIETEKNTNKTASTEPLGYPGKDSKFLAALNT KGKSNGDQFINALKFMSKHEKWAQVISKRKDLNVDNRLDYVEKNGVNVYGSVVTGPTK EIQRMLKNKSVKSANVGEVELWNW*" gene complement(1028511..1029587) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" CDS complement(1029577..1030068) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14651641, 14769884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14651641, 14769884; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma(M))" /protein_id="NP_388833.1" /db_xref="EnsemblGenomes-Gn:BSU09520" /db_xref="EnsemblGenomes-Tr:CAB12791" /db_xref="GOA:O07582" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13019" /db_xref="UniProtKB/Swiss-Prot:O07582" /translation="MTIDEIYQMYMNDVYRFLLSMTKDKHLAEDLLQETFMRAYIHIH SYDHSKVKPWLFQVARNAFIDYVRKHKKEVTISDDLIGSLFQNAVQSPAHQVEIKEVL TGYMSELPDNYREALTLYYLKELNYKEASHIMNISEANFKSVLFRARQRLKALYNRGV NDE*" gene complement(1029577..1030068) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" S_feature complement(1030069..1030171) /Source="Nicolas_S_feature" /locus_tag="new_1030069_1030171_c" /HighExp="Cold, LBGstat, H2O2, G180, Paraq, Oxctl, G135, HPh, dia15, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S330" promotor_-10 complement(1030160..1030179) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1030171) /Source="Nicolas_upshifts" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" promotor_-35 complement(1030193..1030196) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1030209..1030215 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1030226 /Source="Nicolas_upshifts" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" promotor_-10 1030230..1030248 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1030259) /Source="Nicolas_upshifts" /id="D500" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="2.13683" /MaxDrop="4.59517" /score="8.96845329" /energy="-10.2" /TU="NA" /idTUdmin="U757" /TUdmin=1804 /isTUend="FALSE" CDS 1030265..1031260 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10220166, 15019785, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15019785, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldo/keto reductase specific for NADPH; protectsagainst methylglyoxal" /protein_id="NP_388834.1" /db_xref="EnsemblGenomes-Gn:BSU09530" /db_xref="EnsemblGenomes-Tr:CAB12792" /db_xref="GOA:P80874" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:1PZ1" /db_xref="SubtiList:BG13020" /db_xref="UniProtKB/Swiss-Prot:P80874" /translation="MEYTSIADTGIEASRIGLGTWAIGGTMWGGTDEKTSIETIRAAL DQGITLIDTAPAYGFGQSEEIVGKAIKEYGKRDQVILATKTALDWKNNQLFRHANRAR IVEEVENSLKRLQTDYIDLYQVHWPDPLVPIEETAEVMKELYDAGKIRAIGVSNFSIE QMDTFRAVAPLHTIQPPYNLFEREMEESVLPYAKDNKITTLLYGSLCRGLLTGKMTEE YTFEGDDLRNHDPKFQKPRFKEYLSAVNQLDKLAKTRYGKSVIHLAVRWILDQPGADI ALWGARKPGQLEALSEITGWTLNSEDQKDINTILENTISDPVGPEFMAPPTREEI*" gene 1030265..1031260 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" downshifts 1031239 /Source="Nicolas_upshifts" /id="D501" /incds=0 /nref=59 /ntot=160 /MaxReadThrough="6.85446" /MaxDrop="4.90106" /score="10.4379759" /energy="-11.8" /TU="U755" /idTUdmin="U756" /TUdmin="-770" /isTUend="FALSE" promotor_-35 1031322..1031325 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1031340..1031359 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1031345 /Source="Nicolas_upshifts" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" CDS 1031395..1031994 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" /EC_number="2.3.1.51" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1557036, 17557823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1557036, 17557823; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-acylglycerol-phosphate (1-acyl-G3P) acyltransferase" /protein_id="NP_388835.1" /db_xref="EnsemblGenomes-Gn:BSU09540" /db_xref="EnsemblGenomes-Tr:CAB12793" /db_xref="GOA:O07584" /db_xref="InterPro:IPR002123" /db_xref="InterPro:IPR004552" /db_xref="SubtiList:BG13021" /db_xref="UniProtKB/Swiss-Prot:O07584" /translation="MYKFCANALKVILSLRGGVKVYNKENLPADSGFVIACTHSGWVD VITLGVGILPYQIHYMAKKELFQNKWIGSFLKKIHAFPVDRENPGPSSIKTPIKLLKE GEIVGIFPSGTRTSEDVPLKRGAVTIAQMGKAPLVPAAYQGPSSGKELFKKGKMKLII GEPLHQADFAHLPSKERLAAMTEALNQRIKELENKLDQL*" gene 1031395..1031994 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" downshifts 1032009 /Source="Nicolas_upshifts" /id="D502" /incds=0 /nref=189 /ntot=245 /MaxReadThrough="6.36101" /MaxDrop="7.07164" /score="-7.3088084" /energy="-6.1" /TU="U755" /idTUdmin="U756" /TUdmin=0 /isTUend="TRUE" S_feature 1032054..1034008 /Source="Nicolas_S_feature" /locus_tag="new_1032054_1034008" /HighExp="Cold, C30, S8, T-4.40H, Sw, Fru, S0, S7, HPh, G135" /AntisenseName="yhdP" /AntisenseCor="-0.46228251493795502" /AntisenseRegPval="-14.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S331" CDS complement(1032063..1033397) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" /function="16.1: Circulate" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 25182490; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative magnesium efflux pump" /protein_id="NP_388836.1" /db_xref="EnsemblGenomes-Gn:BSU09550" /db_xref="EnsemblGenomes-Tr:CAB12794" /db_xref="GOA:O07585" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13022" /db_xref="UniProtKB/Swiss-Prot:O07585" /translation="MDIVNLILVAVLIALTAFFVASEFAIIRIRGSRIDQLIAEGNKA AIAVKKVTTHLDEYLSACQLGITLTSIGLGVLGESTIERLLHPLFVQMNVPGSLSHVI SFIFAYAIITFLHVVVGELAPKTVAIQKAEAVSMLFAKPLIWFYRIAFPFIWLLNNSA RLLTKAFGLETVSENELAHSEEELRIILSESYKSGEINQSEFKYVNKIFEFDDRLAKE IMIPRTEIVSLPHDIKISEMMDIIQIEKYTRYPVEEGDKDNIIGVINIKEVLTACISG EVSVDSTISQFVNPIIHVIESAPIQDLLVKMQKERVHMAILSDEYGGTAGLVTVEDII EEIVGEIRDEFDIDEISEIRKIGEGHYILDGKVLIDQVNDLLGIHLENEEVDTIGGWF LTQKYDVEKDDSIIEEGCEFIINEIDGHHVAYIEVKKLQEEELLETANQQEA*" gene complement(1032063..1033397) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" downshifts complement(1032082) /Source="Nicolas_upshifts" /id="D503" /incds=0 /nref=284 /ntot=315 /MaxReadThrough="1.96991" /MaxDrop="7.22379" /score="11.1466394" /energy="-9.1" /TU="NA" /idTUdmin="U757" /TUdmin="-19" /isTUend="TRUE" CDS complement(1033458..1033889) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 18048925" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 18048925; Product type r: regulator" /codon_start=1 /transl_table=11 /product="indirect copper efflux transcriptional regulator" /protein_id="NP_388837.1" /db_xref="EnsemblGenomes-Gn:BSU09560" /db_xref="EnsemblGenomes-Tr:CAB12795" /db_xref="GOA:O07586" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13023" /db_xref="UniProtKB/Swiss-Prot:O07586" /translation="MVGRDIDGAETYRISELAALAGVTKRTVDYYTNLGLLTPARSCS NYRYYDENALKRLIFIVDCKKQRLALSDIKDRLENQFPSSAKLDDEIGNLALEIDHMN QNISGILHRFERLKPEDRDKLKSKLPPEKLAVFQSFMLLLS*" gene complement(1033458..1033889) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" promotor_-10 complement(1033901..1033920) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1033911) /Source="Nicolas_upshifts" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" promotor_-35 complement(1033935..1033941) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(1033937..1034037) /Source="Nicolas_upshift_promotors" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 1033972..1033979 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-35" upshifts complement(1033977) /Source="Nicolas_upshifts" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 1033993..1034012 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-10" upshifts 1034010 /Source="Nicolas_upshifts" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" CDS 1034046..1035227 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965, 15103638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_388838.1" /db_xref="EnsemblGenomes-Gn:BSU09570" /db_xref="EnsemblGenomes-Tr:CAB12796" /db_xref="GOA:O07587" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13024" /db_xref="UniProtKB/Swiss-Prot:O07587" /translation="MKLAGLSREVEENLNKGSWIRKLFDEGARLKKEFGEDQVFDFSL GNPIVEPPEAFKRALIEEAEKGSHGYIQNQGLLAAREKVAQFLGSRFEADFSAERIVM TVGAGGALNVALKSIVNPGEEVIILAPYFAEYKLYIENYGGKAVSCPLTSRFEIDIEA VRQSITPQTKGLILNTPHNPTGTVLSQKNIDDLGALLKEIEEKSGQTIYVLFDEPYSQ LIYDEELANPFQSYHRVILASSFSKDLGIAGERLGYIGLDSRMPDADLLINAFVYCNR TLGFVNAPVMMQRAVARMDDLRVDASAYKERRDLMVDILKEAGFEFEMPKGGFFVFPK SPIEDEVAFCVHAAQKYKLLIVPSSGFGMSGHFRLSFSVPIEQIKNSRDIFISLYKDF A*" gene 1034046..1035227 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" downshifts 1035212 /Source="Nicolas_upshifts" /id="D504" /incds=0 /nref=12 /ntot=180 /MaxReadThrough="2.81766" /MaxDrop="3.37889" /score="-5.8634451" /energy="-9.1" /TU="U759" /idTUdmin="U759" /TUdmin="-163" /isTUend="FALSE" S_feature 1035257..1035395 /Source="Nicolas_S_feature" /locus_tag="new_1035257_1035395" /HighExp="Etha, S1, BMM, S2, Cold, MG 45, MG 25, C90, T-5.40H, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S332" misc_feature 1035391..1035410 /Source="Nicolas_upshift_promotors" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1035397..1035553 /Source="Nicolas_S_feature" /locus_tag="new_1035397_1035553" /HighExp="M9-stat, B60, T4.0H, T3.0H, LoTm, S5, T5.0H, S4, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S333" upshifts 1035397 /Source="Nicolas_upshifts" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" CDS 1035554..1036939 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388840.1" /db_xref="EnsemblGenomes-Gn:BSU09590" /db_xref="EnsemblGenomes-Tr:CAB12798" /db_xref="GOA:O07589" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13026" /db_xref="UniProtKB/Swiss-Prot:O07589" /translation="MDDIDSLILIGVLIALTAFFVASEFAIVRVRRSRIDQLITEGNK RAILARRVITDLDEYLSASQLGITLTSIGLGVLGEPAFERLLHPLFEPLGLPDSVSHA VSFAVAYGLITFLHVVVGELAPKTVAIQKAEQLTLLIAGPLRLFYLLLFPFIWILNGS ARLLCGMFGLKPASEHDGSHSEEELRMLLSESLKNGEINPSEYKYVNKIFEFDNRIAK EIMIPRKEMAAVSTEMTMAEMLEVMLKEKYTRWPVTDGDKDSVLGLVNTKHLFSDLLF MTEEERMKMTIHPYVRPVIEVIETIPVHDLLIKMQRERIHMAILSDEYGGTSGLVTTE DILEEIVGEIRDEFDEDEQPLIQKLGDGHYVMDGKVRIDQVNSLLGASIQEDVDTIGG LILKENIDIEAGESIRIGSYTIKVLKMDGRLIKQIDIKEEAGNTTGITAHHKLPLPEP VMLNSATLSEK*" gene 1035554..1036939 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" downshifts 1036829 /Source="Nicolas_upshifts" /id="D505" /incds=1 /nref=120 /ntot=240 /MaxReadThrough="5.11037" /MaxDrop="3.79021" /score="19.6985636" /energy="-10.5" /TU="U760" /idTUdmin="U760" /TUdmin="-86" /isTUend="FALSE" downshifts 1036915 /Source="Nicolas_upshifts" /id="D506" /incds=0 /nref=129 /ntot=245 /MaxReadThrough="1.68999" /MaxDrop="6.12682" /score="19.6985636" /energy="-10.5" /TU="NA" /idTUdmin="U760" /TUdmin=0 /isTUend="TRUE" CDS complement(1036953..1037309) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 17196979, 22194412, 27824896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fluoride efflux channel component A" /protein_id="NP_388841.1" /db_xref="EnsemblGenomes-Gn:BSU09600" /db_xref="EnsemblGenomes-Tr:CAB12799" /db_xref="GOA:O07590" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13027" /db_xref="UniProtKB/Swiss-Prot:O07590" /translation="MTLAGIFIGGGLGAMLRFWLGNVITAKTKGLSLPIGILTVNILG ALGLGIFTGLHVANASVSLIIGTGFFGAFTTFSTFSVETIQLLMAKRVKESILYIVLT LCGSLFAFWCGWTITI*" gene complement(1036953..1037309) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" CDS complement(1037306..1037701) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" /function="16.1: Circulate" /function="16.4: Excrete" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 22194412, 27824896; Product type t : transporter" /codon_start=1 /transl_table=11 /product="subunit of fluoride efflux transporter" /protein_id="NP_388842.1" /db_xref="EnsemblGenomes-Gn:BSU09610" /db_xref="EnsemblGenomes-Tr:CAB12800" /db_xref="GOA:O07591" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13028" /db_xref="UniProtKB/Swiss-Prot:O07591" /translation="MKIYSAVFIGGALGACLRYGLNLWIHTGQFPAATWLENAAGSLL LGILTGFFMIGAKRPLLSAFLGTGFCGGFTTMSTFSKETVMLLQGQPSLALLYVAASL ISGIIFALIGVFVGRRIAGIQQRKGLQEK*" gene complement(1037306..1037701) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" CDS complement(1037688..1038419) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" /EC_number="3.1.4.46" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8012593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycerophosphodiester phosphodiesterase" /protein_id="NP_388843.1" /db_xref="EnsemblGenomes-Gn:BSU09620" /db_xref="EnsemblGenomes-Tr:CAB12801" /db_xref="GOA:O07592" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG13029" /db_xref="UniProtKB/Swiss-Prot:O07592" /translation="MYIIAHRGASGYAPENTIAAFDLAVKMNADMIELDVQLTKDRQI VVIHDDRVDRTTNGSGFVKDFTLEELQKLDAGSWYGPAFQGERIPTLEAVLKRYHKKI GLLIELKGHPSQVGIEEEVGQLLGQFSFSINNIVQSFQFRSVQRFRELYPSIPTAVIT RPNFGMLSRNQMKAFRSFANYVNIKHTRLNRLMIGSINKNGLNIFAWTVNNQKTAAKL QAMGVDGIVTDYPDFIIKDGKHENI*" gene complement(1037688..1038419) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" misc_feature complement(1038444..1038463) /Source="Nicolas_upshift_promotors" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1038465) /Source="Nicolas_upshifts" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" promotor_-35 1038512..1038520 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1038529 /Source="Nicolas_upshifts" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" promotor_-10 1038534..1038549 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1038543..1038616 /Source="Nicolas_S_feature" /locus_tag="new_1038543_1038616" /HighExp="S5, S4, S6, S7, S8, S3, B60, Pyr, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.563" /TUlongSig="NA" /TUlongPSig="NA" /label="S334" promotor_-35 1038603..1038604 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1038618 /Source="Nicolas_upshifts" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" promotor_-10 1038620..1038639 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1038653..1038760 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388844.1" /db_xref="EnsemblGenomes-Gn:BSU09630" /db_xref="EnsemblGenomes-Tr:CAB12802" /db_xref="InterPro:IPR035384" /db_xref="SubtiList:BG13030" /db_xref="UniProtKB/Swiss-Prot:O07593" /translation="MGKGRIRVEERIKAETDAEMQKATLLDQTQTKKGK*" gene 1038653..1038760 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" S_feature 1038761..1038814 /Source="Nicolas_S_feature" /locus_tag="new_1038761_1038814" /HighExp="Sw, BC, LPhT, HiOs, S4, HiTm, S5, B36, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S335" downshifts 1038785 /Source="Nicolas_upshifts" /id="D507" /incds=0 /nref=177 /ntot=225 /MaxReadThrough="0.97838" /MaxDrop="7.47175" /score="21.9742676" /energy="-14.5" /TU="NA" /idTUdmin="U762" /TUdmin=0 /isTUend="TRUE" misc_feature 1038865..1038884 /Source="Nicolas_upshift_promotors" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1038871 /Source="Nicolas_upshifts" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" CDS 1038909..1040024 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" /function="16.8: Protect" /function="16.12: Sense" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12077558, 15849754, 16850406, 17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12077558, 15849754, 16850406, 17665170, 18310427, 19252899; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small conductance mechano-sensitive channel" /protein_id="NP_388845.1" /db_xref="EnsemblGenomes-Gn:BSU09640" /db_xref="EnsemblGenomes-Tr:CAB12803" /db_xref="GOA:O07594" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR006686" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13031" /db_xref="UniProtKB/Swiss-Prot:O07594" /translation="MPDYLQQYFTLDNIIQIGISLAILLVFLILRKLFTRYFFNLLFN LTNRPKTEIFKQVVLAFDKPARWFFVALGLFLAIRYSPFLDEQMPVISKIYRSLIVAL LCWGLCNLTATSSFIFHKVNQRFELDMDDILAPFLSKLLRFVIIALSVSVIAQEFNYD VNGFVAGLGLGGLAFALAAKDTISNFFGGIIIITEKPFTIGDWVETSTVTGSVEDITF RSTRFRTAQGALVTVPNSTLSMEAITNWTRMTKRQITFSIHVSYATPIENLERSIHSL RTMLLEHEGVDNEIIMVNFDTFADSYYNLFFNFYTKTTVWAENLNIREDINYKIIEIL GAEGVQFAYPGQMVVVKQKHESDQFQVNLNKEEKERA*" gene 1038909..1040024 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" downshifts 1040004 /Source="Nicolas_upshifts" /id="D508" /incds=0 /nref=5 /ntot=141 /MaxReadThrough="3.45709" /MaxDrop="3.93891" /score="2.31392404" /energy="-12.3" /TU="U764" /idTUdmin="U764" /TUdmin="-783" /isTUend="FALSE" misc_feature 1040061..1040080 /Source="Nicolas_upshift_promotors" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1040061 /Source="Nicolas_upshifts" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" CDS 1040094..1040837 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16768447, 19136592, 26708127, 27987242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16768447, 19136592, 26708127, 27987242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirtuin NAD-dependent deacetylase" /protein_id="NP_388846.1" /db_xref="EnsemblGenomes-Gn:BSU09650" /db_xref="EnsemblGenomes-Tr:CAB12804" /db_xref="GOA:O07595" /db_xref="InterPro:IPR003000" /db_xref="InterPro:IPR026590" /db_xref="InterPro:IPR028628" /db_xref="InterPro:IPR029035" /db_xref="SubtiList:BG13032" /db_xref="UniProtKB/Swiss-Prot:O07595" /translation="METFKSILHEAQRIVVLTGAGMSTESGIPDFRSAGGIWTEDASR MEAMSLDYFLSYPRLFWPKFKELFQMKMSGSFEPNEGHLLLAELEKQGKQVDIFTQNI DGLHKKAGSRHVYELHGSIQTAACPACGARYDLPHLLEREVPECTAAGNNGDICGTVL KTDVVLFGDAVMHFDTLYEKLDQADLLLVIGTSLEVAPARFVPEDASLIPGMKKVIIN LEPTYCDSLFDMVIHQKIGEFARSLGMKK*" gene 1040094..1040837 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" downshifts 1040809 /Source="Nicolas_upshifts" /id="D509" /incds=0 /nref=3 /ntot=82 /MaxReadThrough="1.93149" /MaxDrop="2.85561" /score="9.76884826" /energy="-9.2" /TU="NA" /idTUdmin="U765" /TUdmin=0 /isTUend="TRUE" CDS complement(1040861..1041709) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polysaccharide deacetylase" /protein_id="NP_388847.1" /db_xref="EnsemblGenomes-Gn:BSU09660" /db_xref="EnsemblGenomes-Tr:CAB12805" /db_xref="GOA:O07596" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG13046" /db_xref="UniProtKB/Swiss-Prot:O07596" /translation="MRQTRGEASPSAVSLAFKFASLAVLCVLLLLMVILGYSNSSTKA KEVTVTTNGQLRDEKESLKLKNDSPDLLIKHLQTKQNMGDKTVYLTFDDGPSAVTTRL LDVLKSADVKATFFMLSPRMNEFKQAVKRAEKEGHALGLHGVTHNNRLFYQTPTSPLK EMQEARDTLQDITGYKTDLVRTPYGSKPSLTASQIRNLEKDGFVYWDWTIDSMDWKYR NSQYVTAVLQQLENMEHSSSSRPNVILMHDLPATVNALPVLINKLKEKGYSFGVLEDT MVPVHE*" gene complement(1040861..1041709) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" downshifts complement(1040885) /Source="Nicolas_upshifts" /id="D510" /incds=0 /nref=126 /ntot=242 /MaxReadThrough="2.03966" /MaxDrop="4.72968" /score="-7.82934513" /energy="-9.2" /TU="NA" /idTUdmin="U767" /TUdmin=0 /isTUend="TRUE" promotor_-35 1041705..1041710 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1041710..1041809) /Source="Nicolas_S_feature" /locus_tag="new_1041710_1041809_c" /HighExp="Cold, T3.0H, T2.30H, T3.30H, T4.0H, T2.0H, HPh, C30, T1.30H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S336" promotor_-10 1041726..1041744 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1041728 /Source="Nicolas_upshifts" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" S_feature 1041733..1041928 /Source="Nicolas_S_feature" /locus_tag="new_1041733_1041928" /HighExp="S5, S4, S6, S3, S7, S8, LoTm, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S337" promotor_-10 complement(1041798..1041817) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1041812) /Source="Nicolas_upshifts" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" promotor_-35 complement(1041832..1041835) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1041927..1041946 /Source="Nicolas_upshift_promotors" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1041930..1041993 /Source="Nicolas_S_feature" /locus_tag="new_1041930_1041993" /HighExp="BC, T2.30H, T3.0H, T3.30H, T4.0H, T5.0H, T2.0H, T1.30H, S4, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S338" upshifts 1041930 /Source="Nicolas_upshifts" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" CDS 1041994..1042842 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" /EC_number="2.6.1.21" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9003455, 17005988; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine aminotransferase" /protein_id="NP_388848.1" /db_xref="EnsemblGenomes-Gn:BSU09670" /db_xref="EnsemblGenomes-Tr:CAB12806" /db_xref="GOA:O07597" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005784" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG13045" /db_xref="UniProtKB/Swiss-Prot:O07597" /translation="MKVLVNGRLIGRSEASIDLEDRGYQFGDGIYEVIRVYKGVLFGL REHAERFFRSAAEIGISLPFSIEDLEWDLQKLVQENAVSEGAVYIQTTRGVAPRKHQY EAGLEPQTTAYTFTVKKPEQEQAYGVAAITDEDLRWLRCDIKSLNLLYNVMTKQRAYE AGAFEAILLRDGVVTEGTSSNVYAVINGTVRTHPANRLILNGITRMNILGLIEKNGIK LDETPVSEEELKQAEEIFISSTTAEIIPVVTLDGQSIGSGKPGPVTKQLQAAFQESIQ QAASIS*" gene 1041994..1042842 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" downshifts 1042833 /Source="Nicolas_upshifts" /id="D511" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="2.27201" /MaxDrop="6.88888" /score="21.6239924" /energy="-11.5" /TU="U768" /idTUdmin="U766" /TUdmin=0 /isTUend="TRUE" CDS complement(1042885..1044246) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735849, 11274110, 15849754, 16850406, 17937670" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735849, 11274110, 15849754, 16850406, 17937670; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_388849.1" /db_xref="EnsemblGenomes-Gn:BSU09680" /db_xref="EnsemblGenomes-Tr:CAB12807" /db_xref="GOA:O07553" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG13044" /db_xref="UniProtKB/Swiss-Prot:O07553" /translation="MDSQKKLTFPLAVGLFIFMLCIIISCLFLLHVEPHIPLFLSVVM LSAAALWFGFPWKSIEKGIVDGIKNGVQPIIVLALIGILIGAWMYSGAIPTMTVYALS FIEPSHLLLTALFSCMIISTLVGSSLTTVSTIGVALIGVASAAGVPLEWTAGAVICGA CFGDKMSPMSDTTNFAAGIGEIPIFEHIRHMMGTTIPALLITVVLFYFLGSSVSADAA STDNIQQVITGIKDAANVTPWALLSPLLVVLLAMKRVSVIPVLTAGIISSGILTAIFV PYSSLQAFMTALQNGTTFETDNEAAAKIINRGGLQSMMGSVSLIMIAFALGGLMEKIG LISALLEGVMKGIRSKGRLVAATVCSSIGVNLATGEQYLSILIPGQSFKSLYDKRNIQ RKFLTRSLEDGGTLINPLIPWGVSGAFMASALGVPVIDYIPFTFFLYISPMISILIGF VKK*" gene complement(1042885..1044246) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" downshifts complement(1042909) /Source="Nicolas_upshifts" /id="D512" /incds=0 /nref=7 /ntot=77 /MaxReadThrough="0.50034" /MaxDrop="3.60175" /score="1.04025421" /energy="-11.5" /TU="NA" /idTUdmin="U769" /TUdmin=22 /isTUend="TRUE" S_feature complement(1044247..1044317) /Source="Nicolas_S_feature" /locus_tag="new_1044247_1044317_c" /HighExp="B60, G135, Etha, LBGexp, G150, Diami, Paraq, G180, H2O2, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S339" misc_feature complement(1044290..1044309) /Source="Nicolas_upshift_promotors" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1044317) /Source="Nicolas_upshifts" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" CDS complement(1044373..1044873) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" /function="16.12: Sense" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 16159758, 27464829; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein, UspA family" /protein_id="NP_388850.2" /db_xref="EnsemblGenomes-Gn:BSU09690" /db_xref="EnsemblGenomes-Tr:CAB12808" /db_xref="GOA:O07552" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13043" /db_xref="UniProtKB/Swiss-Prot:O07552" /translation="MFHADRIIVAFDGSENSKKALLTAIDLAKTVNAAITVAHSHDMK DNQTVIDPPRPAAEASYISGGMTSVPDPLISDVTSPEPMIYEDRTEEVIAEARMMLNE QQADGDIDILEGDPAESIIEHANRISADMIVTGSRDQNRLKKLIFGSVSEKLSAKSDI PVLIVK*" gene complement(1044373..1044873) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" downshifts complement(1044405) /Source="Nicolas_upshifts" /id="D513" /incds=0 /nref=10 /ntot=63 /MaxReadThrough="4.74071" /MaxDrop="5.69273" /score="4.44189378" /energy="-12.2" /TU="U770" /idTUdmin="U770" /TUdmin="-1320" /isTUend="FALSE" promotor_-10 complement(1044895..1044913) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1044915) /Source="Nicolas_upshifts" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" promotor_-35 complement(1044928..1044934) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1044952..1044959 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1044967..1045036 /Source="Nicolas_S_feature" /locus_tag="new_1044967_1045036" /HighExp="C90, M9-stat, BC, T1.30H, T3.30H, Sw, T5.0H, GM 15, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S340" upshifts 1044968 /Source="Nicolas_upshifts" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" promotor_-10 1044974..1044993 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1045037..1045198 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" /experiment="publication(s) with functional evidences, PMID:25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25217586; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator leader peptide" /protein_id="NP_388851.1" /db_xref="EnsemblGenomes-Gn:BSU09700" /db_xref="EnsemblGenomes-Tr:CAB12809" /db_xref="SubtiList:BG13042" /db_xref="UniProtKB/Swiss-Prot:O07551" /translation="MFIKQFHIGAANLLFCFRERFFRSDRALKSAVRNISVKKGMELT LHAFFIYKI*" gene 1045037..1045198 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" downshifts 1045128 /Source="Nicolas_upshifts" /id="D514" /incds=1 /nref=29 /ntot=180 /MaxReadThrough="5.31538" /MaxDrop="4.59672" /score="25.6910195" /energy="-14.4" /TU="U771" /idTUdmin="U768" /TUdmin=2273 /isTUend="FALSE" S_feature 1045199..1045317 /Source="Nicolas_S_feature" /locus_tag="new_1045199_1045317" /HighExp="LPhT, S7, S6, T-1.10H, Sw, LBGstat, S5, T-0.40H, S8, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S341" CDS 1045318..1047075 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388852.1" /db_xref="EnsemblGenomes-Gn:BSU09710" /db_xref="EnsemblGenomes-Tr:CAB12810" /db_xref="GOA:O07550" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13041" /db_xref="UniProtKB/Swiss-Prot:O07550" /translation="MFSVLKKLGWFFKAYWLRYTIAIVLLLAVNVIEMFPPKLLGNAI DDMKAGAFTAEGLLFYIGIFFVLTAAVYIMSYFWMHQLFGGANLMEKILRTKLMGHLL TMSPPFYEKNRTGDLMARGTNDLQAVSLTTGFGILTLVDSTMFMMTIFLTMGFLISWK LTFAAIIPLPVMAIAISLYGSKIHERFTEAQNAFGALNDRVLESVSGVRVIRAYVQET NDVRRFNEMTADVYQKNMKVAFIDSLFEPTVKLLVGASYLIGLGYGAFLVFRNELTLG ELVSFNVYLGMMIWPMFAIGELINVMQRGNASLDRVNETLSYETDVTDPKQPADLKEP GDIVFSHVSFTYPSSTSDNLQDISFTVRKGQTVGIAGKTGSGKTTIIKQLLRQYPPGE GSITFSGVPIQQIPLDRLRGWIGYVPQDHLLFSRTVKENILYGKQDATDKEVQQAIAE AHFEKDLHMLPSGLETMVGEKGVALSGGQKQRISIARALMANPEILILDDSLSAVDAK TEAAIIKNIRENRKGKTTFILTHRLSAVEHADLILVMDGGVIAERGTHQELLANNGWY REQYERQQLFTAEEGGAGA*" gene 1045318..1047075 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" CDS 1047072..1049093 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding subunit)" /protein_id="NP_388853.1" /db_xref="EnsemblGenomes-Gn:BSU09720" /db_xref="EnsemblGenomes-Tr:CAB12811" /db_xref="GOA:O07549" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13040" /db_xref="UniProtKB/Swiss-Prot:O07549" /translation="MKIGKTLWRYALLYRKLLITAVLLLTVAVGAELTGPFIGKKMID DHILGIEKTWYEAAEKDKNAVQFHGVSYVREDRLQEPVSKAKEAHIYQVGMAFYFVDQ AVSFDGNRTVSDGKLTITNGDKSRAYAAEKLTKQELFQFYQPEIKGMVLLICLYGGLL VFSVFFQYGQHYLLQMSANRIIQKMRQDVFSHIQKMPIRYFDNLPAGKVVARITNDTE AIRDLYVTVLSTFVTSGIYMFGIFTALFLLDVKLAFVCLAIVPIIWLWSVIYRRYASY YNQKIRSINSDINAKMNESIQGMTIIQAFRHQKETMREFEELNESHFYFQNRMLNLNS LMSHNLVNVIRNLAFVCLIWHFGGASLNAAGIVSIGVLYAFVDYLNRLFQPITGIVNQ FSKLELARVSAGRVFELLEEKNTEEAGEPAKERALGRVEFRDVSFAYQEGEEVLKHIS FTAQKGETVALVGHTGSGKSSILNLLFRFYDAQKGDVLIDGKSIYNMSRQELRSHMGI VLQDPYLFSGTIGSNVSLDDERMTEEEIKNALRQVGAEPLLKKLPKGINEPVIEKGST LSSGERQLISFARALAFDPAILILDEATAHIDTETEAVIQKALDVVKQGRTTFVIAHR LSTIRNADQILVLDKGEIVERGNHEELMALEGQYYQMYELQKGQKHSIA*" gene 1047072..1049093 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" downshifts 1049081 /Source="Nicolas_upshifts" /id="D515" /incds=0 /nref=69 /ntot=230 /MaxReadThrough="0.741399999999999" /MaxDrop="5.11492" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U771" /TUdmin=0 /isTUend="TRUE" CDS complement(1049142..1049762) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-flavin oxidoreductase" /protein_id="NP_388854.1" /db_xref="EnsemblGenomes-Gn:BSU09730" /db_xref="EnsemblGenomes-Tr:CAB12812" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13039" /db_xref="UniProtKB/Swiss-Prot:O07548" /translation="MKIALLGASGRVGQAFLTQAAADERFDIFALIRSQHADLPLSKD RTVMGNARRLEDVKKIMENAEIVISCLGTDGDDTLSTAMAHILSVMEEQHIKRLITIG TAGILDSRYEPGKYRFETNESKRKQTRAAKEHAKVYEMLKESSLDWTIICPTYLPDGT ATGVYRTERNVLPEGGTSISVGDTADFLYRELVTGEYVGNRVGLAY*" gene complement(1049142..1049762) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" downshifts complement(1049157) /Source="Nicolas_upshifts" /id="D516" /incds=0 /nref=19 /ntot=169 /MaxReadThrough="1.82652" /MaxDrop="3.00293" /score="-0.293143554" /energy="-10.9" /TU="NA" /idTUdmin="U772" /TUdmin=0 /isTUend="TRUE" promotor_no_box 1049747..1049847 /Source="Nicolas_upshift_promotors" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(1049776..1049795) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1049791) /Source="Nicolas_upshifts" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" CDS complement(1049801..1049926) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388855.1" /db_xref="EnsemblGenomes-Gn:BSU09740" /db_xref="EnsemblGenomes-Tr:CAB12813" /db_xref="SubtiList:BG13038" /db_xref="UniProtKB/Swiss-Prot:O07547" /translation="MSFITIVNWELVQFVSVSMIHEYVSHRSVYLYRYSFPRCSN*" gene complement(1049801..1049926) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" upshifts 1049807 /Source="Nicolas_upshifts" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1049810..1049813) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1049940..1049959) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1049949) /Source="Nicolas_upshifts" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" promotor_-35 complement(1049973..1049982) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1050005 /Source="Nicolas_upshifts" /id="D517" /incds=0 /nref=6 /ntot=22 /MaxReadThrough="0.352760000000001" /MaxDrop="4.67633" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U773" /TUdmin=88 /isTUend="FALSE" CDS complement(1050031..1050234) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:3009398, 9572981, 16707666, 19659696, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009398, 9572981, 16707666, 19659696, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (beta-type SASP)" /protein_id="NP_388856.1" /db_xref="EnsemblGenomes-Gn:BSU09750" /db_xref="EnsemblGenomes-Tr:CAB12814" /db_xref="GOA:P04832" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10787" /db_xref="UniProtKB/Swiss-Prot:P04832" /translation="MANQNSSNDLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRANG SVGGEITKRLVSFAQQQMGGRVQ*" gene complement(1050031..1050234) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" downshifts complement(1050036) /Source="Nicolas_upshifts" /id="D518" /incds=0 /nref=72 /ntot=93 /MaxReadThrough="1.27819" /MaxDrop="8.55895" /score="22.2113888" /energy="-16" /TU="NA" /idTUdmin="U776" /TUdmin=1 /isTUend="TRUE" S_feature complement(1050235..1050345) /Source="Nicolas_S_feature" /locus_tag="new_1050235_1050345_c" /HighExp="S8, S5, S7, S6, S4, G/S, Pyr, ferm, BT, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S342" promotor_no_box 1050275..1050375 /Source="Nicolas_upshift_promotors" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1050335 /Source="Nicolas_upshifts" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(1050351) /Source="Nicolas_upshifts" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" promotor_-10 complement(1050355..1050366) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1050381..1050387) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1050443..1050661) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation / germination island)" /protein_id="NP_388857.1" /db_xref="EnsemblGenomes-Gn:BSU09760" /db_xref="EnsemblGenomes-Tr:CAB12815" /db_xref="InterPro:IPR017263" /db_xref="SubtiList:BG13037" /db_xref="UniProtKB/Swiss-Prot:O07546" /translation="MAVMISHFSWKPLFPKEKLPGWKISFYYKGTHYEGIYHKSGEIE WGDLFPARADEPALTNEIHELMLFHIYD*" gene complement(1050443..1050661) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" downshifts complement(1050477) /Source="Nicolas_upshifts" /id="D519" /incds=0 /nref=5 /ntot=83 /MaxReadThrough="0.43384" /MaxDrop="3.42951" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U777" /TUdmin=110 /isTUend="FALSE" promotor_-10 complement(1050702..1050721) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1050719) /Source="Nicolas_upshifts" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" promotor_-35 complement(1050735..1050742) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1050811..1052172) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" /function="16.5: Explore" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15231775, 25035995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 25035995; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat associated protein" /protein_id="NP_388858.2" /db_xref="EnsemblGenomes-Gn:BSU09770" /db_xref="EnsemblGenomes-Tr:CAB12816" /db_xref="GOA:O07545" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13036" /db_xref="UniProtKB/Swiss-Prot:O07545" /translation="MNPKRFLIGIDKTSENTLFLPSSLKQDGLLHAAFGTKVVRCHVA YRRHLEQTVLLSENLFHELLLPHRSRADILIHDHTVHIGPLVGIFTAGFTVSLERPFK DRSLFFSKLVTLHEQAGGYCFVFGAHQINWEEGTIEGLLYRENGWEKKIVPLPNVVYD RLPNRKIEDSLLLQHTKKRLIDEYQIPWFNKTFFNKWNVHQLLEKDPRTAPFLPRSEL TPSVELIDELCGAYKKVYIKPANGALGTGIYQLTRTDGGLTVKHTNDAKTFTSIDYSD AASFLAEFQKHHNPSDFLIQQGVDLIEFQGKPADFRVHTNKNRKGKWTVTAIAVKISG KNSITTHLSNGGTVKTLAEVYDDPAERVEVIKKLSAAALTASHVLHDHIEGFIGEIGF DFGIDQNGKVWMFEANSRPGRSIFSHPNLHHVDSLTKRRSFEYASYLSEKAITSPEAL WPS*" gene complement(1050811..1052172) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" downshifts complement(1050829) /Source="Nicolas_upshifts" /id="D520" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.33323" /MaxDrop="3.7968" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U779" /TUdmin=0 /isTUend="TRUE" downshifts complement(1050873) /Source="Nicolas_upshifts" /id="D521" /incds=1 /nref=2 /ntot=45 /MaxReadThrough="5.29177" /MaxDrop="3.36501" /score="37.4339943" /energy="-11.8" /TU="U779" /idTUdmin="U779" /TUdmin="-44" /isTUend="FALSE" CDS complement(1052162..1053253) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231775, 25035995; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat associated protein, subunit C" /protein_id="NP_388859.1" /db_xref="EnsemblGenomes-Gn:BSU09780" /db_xref="EnsemblGenomes-Tr:CAB12817" /db_xref="GOA:O07544" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13035" /db_xref="UniProtKB/Swiss-Prot:O07544" /translation="MITLGFMSLSRQHEADYSAELAKRAPEFGIRFIRFTPFDISPDT LRVKASVYHSASSTWNETEMAIPDYIYDRCFYGKDSHSQKAKPIVEWLKKYPKTEFIG RGLPDKWTVLHDLQQHSVINPYIPETIKVSRYEQIHSFLSKEKACILKPAFGAGGRGV ILLKLGKKNITATYHIGKDKQTKTFSNQTSFKTWCKKVLQHQYLLQPYLNIQDKEQYP CDIRLFMEKNEAGEWNTVGKAVRRGYKHGLLANLSGGSDALTFDSWFEDIPKKQQVVL LDDVFSITQSVPYYLDERYGPLFELGLDICLAKDGRIWILDINSKPGRKSILRVSPEQ KEQLYTCPLKRCQYLFSEQSQKGVLPRES*" gene complement(1052162..1053253) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" promotor_-10 complement(1052577..1052591) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1052589) /Source="Nicolas_upshifts" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1052605..1052613) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1053254..1053359) /Source="Nicolas_S_feature" /locus_tag="new_1053254_1053359_c" /HighExp="S4, B36, S5, S6, S7, S8, B60, S3, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S343" promotor_-10 complement(1053343..1053361) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1053363) /Source="Nicolas_upshifts" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" promotor_-35 complement(1053377..1053382) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1053425..1053432 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1053447..1053466 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1053458 /Source="Nicolas_upshifts" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" CDS 1053520..1054653 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16684363" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388860.1" /db_xref="EnsemblGenomes-Gn:BSU09790" /db_xref="EnsemblGenomes-Tr:CAB12818" /db_xref="GOA:O07543" /db_xref="InterPro:IPR007383" /db_xref="InterPro:IPR016991" /db_xref="SubtiList:BG13034" /db_xref="UniProtKB/Swiss-Prot:O07543" /translation="MGIAGTFIFMIVIGAAIGAVTNHLAIQMLFRPYKAYYLFGKRVP FTPGLIPRRRDELAKQMGLMVVNHLLTPEGIKKRLVSDAAKTQALRVGEQLIQKLSLS EVTVKEALEKAGMKRPEKAADAWISSWTDDKLHELFRQYGDQSLKELVPIEVQEKLEE KIPMISGYILSRSVRYFESDEGKIRLGNMIDDFLKERGMLGSMVQLFLGNSSLADRVL PELLKFLRNEETNKLLSDLLKNEWGKLREYTFNEADEKWNAKALIFSLKRRVLQAFST APFFNNTIGTLTVRYESELTQQMLPALLDKLLEGISSNLESVLKRLRLEEIVKEQVDQ FPVERLEEMVLSISKKEFKMITYLGGLLGGIIGAIQALFVILF*" gene 1053520..1054653 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" S_feature 1054654..1054745 /Source="Nicolas_S_feature" /locus_tag="new_1054654_1054745" /HighExp="S4, S5, S6, BT, S3, S7, dia15, B36, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S344" CDS 1054746..1055099 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19429628, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388861.1" /db_xref="EnsemblGenomes-Gn:BSU09800" /db_xref="EnsemblGenomes-Tr:CAB12819" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="PDB:2OEE" /db_xref="SubtiList:BG13033" /db_xref="UniProtKB/Swiss-Prot:O07542" /translation="MAVNFYDVAYDLENALRGSEEFTRLKNLYDEVNADESAKRMFEN FRDVQLRLQQKQMAGEEITQEEVTQAQKTVALVQQHEKISQLMEAEQRMSMLIGELNK IIMKPLEELYGSVEG*" gene 1054746..1055099 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" downshifts 1055087 /Source="Nicolas_upshifts" /id="D522" /incds=0 /nref=159 /ntot=259 /MaxReadThrough="1.55668" /MaxDrop="5.9901" /score="24.5275597" /energy="-12.3" /TU="NA" /idTUdmin="U780" /TUdmin=0 /isTUend="TRUE" CDS complement(1055143..1056216) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290, 22933559" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388862.1" /db_xref="EnsemblGenomes-Gn:BSU09810" /db_xref="EnsemblGenomes-Tr:CAB12820" /db_xref="GOA:O07541" /db_xref="InterPro:IPR011989" /db_xref="InterPro:IPR014825" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR021133" /db_xref="SubtiList:BG13002" /db_xref="UniProtKB/Swiss-Prot:O07541" /translation="MADLKEIYNEELISQLIHHVRSSYPDFNKNRFLDTLRLEDWPEL TLKERMRRVTVSLYETLPKQYVEALTILRDTAPHFKGLSGILFPDYVEQYGLAHWEES IKALESFTQYSTSEFAVRPFLLLDQEKMIAQLLAWSEHKNEHVRRLASEGSRPRLPWG KSIPALKSDPSPVLPILEKLMQDESLYVRKSVANNLNDISKTHPHLLRKVADQWYGTH PHTDWIIKHAYRTLLKKGDKQALALFGYENADSIQLHDLTCQPKRIVIGESLEFSFYI HSDRDQKVRIEYAIDFVKARGQRHQKVFKITETNIRKNETKSYTRIQSFKDLTTRKHY KGIHTLSVIINGEVKDSLDFQVC*" gene complement(1055143..1056216) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" downshifts complement(1055250) /Source="Nicolas_upshifts" /id="D523" /incds=1 /nref=16 /ntot=173 /MaxReadThrough="3.78071" /MaxDrop="3.586" /score="4.43596345" /energy="-12.3" /TU="U781" /idTUdmin="U781" /TUdmin="-109" /isTUend="FALSE" promotor_-10 complement(1056238..1056257) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1056250) /Source="Nicolas_upshifts" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" promotor_-35 complement(1056271..1056278) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1056353..1056360 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1056373 /Source="Nicolas_upshifts" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" promotor_-10 1056375..1056394 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1056384..1056537 /Source="Nicolas_S_feature" /locus_tag="new_1056384_1056537" /HighExp="M9-stat, BC, T0.30H, T1.30H, Lbstat, T1.0H, T3.30H, T2.0H, T3.0H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S345" downshifts 1056494 /Source="Nicolas_upshifts" /id="D524" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="7.40404" /MaxDrop="2.6506" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-1056" /isTUend="FALSE" S_feature 1056539..1056622 /Source="Nicolas_S_feature" /locus_tag="new_1056539_1056622" /HighExp="M9-stat, B60, T2.0H, T1.30H, T0.30H, T2.30H, T3.0H, T1.0H, Lbtran, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S346" downshifts 1056579 /Source="Nicolas_upshifts" /id="D525" /incds=0 /nref=70 /ntot=231 /MaxReadThrough="4.88371" /MaxDrop="4.4099" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-971" /isTUend="FALSE" promotor_-35 1056635..1056640 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1056656..1056674 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1056665 /Source="Nicolas_upshifts" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" CDS 1056702..1057568 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388864.2" /db_xref="EnsemblGenomes-Gn:BSU09830" /db_xref="EnsemblGenomes-Tr:CAB12822" /db_xref="GOA:O07539" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR036412" /db_xref="PDB:3DNP" /db_xref="SubtiList:BG13000" /db_xref="UniProtKB/Swiss-Prot:O07539" /translation="MSKQLLALNIDGALLRSNGKIHQATKDAIEYVKKKGIYVTLVTN RHFRSAQKIAKSLKLDAKLITHSGAYIAEKIDAPFFEKRISDDHTFNIVQVLESYQCN IRLLHEKYSIGNKKKVNSNLLGKALIHPSDPIFYPVQFVESLSDLLMDEPVSAPVIEV YTEHDIQHDITETITKAFPAVDVIRVNDEKLNIVPKGVSKEAGLALVASELGLSMDDV VAIGHQYDDLPMIELAGLGVAMGNAVPEIKRKADWVTRSNDEQGVAYMMKEYFRMQQR KGFLDKFHMKRV*" gene 1056702..1057568 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" downshifts 1057550 /Source="Nicolas_upshifts" /id="D526" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="3.99904" /MaxDrop="4.7771" /score="15.7706912" /energy="-16.6" /TU="U783" /idTUdmin="U782" /TUdmin=0 /isTUend="TRUE" promotor_-35 1057613..1057616 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1057631..1057650 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1057639 /Source="Nicolas_upshifts" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" CDS 1057680..1059185 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" /EC_number="1.3.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10498703, 21255303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498703, 21255303; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_388865.1" /db_xref="EnsemblGenomes-Gn:BSU09840" /db_xref="EnsemblGenomes-Tr:CAB12823" /db_xref="GOA:Q796V8" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023995" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG12999" /db_xref="UniProtKB/Swiss-Prot:Q796V8" /translation="MQIKIEGIHDDRLHRPLQNIANLFYEECELAYGGEEPADFVISL ALSQTDEHVTVSGEVKGTGIKEQHTKFFSPDMTEKEAFKQVKNTISYVYLNLLQAHTG ITQKWGILTGIRPTKLLHKKLQSGMSKEQAHAELKKDYLIHDEKIMLMQEIVDRQLAA VPDLYRVKDEVSIYIGIPFCPTKCAYCTFPAYAIQGQAGRVGSFLWGLHYEMQKIGEW LKEHDVKVTTIYFGGGTPTSITAEEMDLLYEEMVRSFPDVKNIREITVEAGRPDTITE EKLAVLNKYDIDRISINPQSYENETLKAIGRHHTVEETIEKYHLSRQHGMNNINMDLI IGLPGEGVKEFRHSLSETEKLMPESLTVHTLSFKRASEMTRNKHKYKVAGREEVSQMM EDAVAWTKEHGYVPYYLYRQKNILGNLENVGYSLPGQESIYNIMIMEEVQTIIGIGCG AASKFIDRDTGKITHFANPKDPKSYNERFEHYTDEKIKYLEQIFEKTTKQH*" gene 1057680..1059185 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" downshifts 1059155 /Source="Nicolas_upshifts" /id="D527" /incds=0 /nref=113 /ntot=234 /MaxReadThrough="0.523269999999999" /MaxDrop="5.05369" /score="38.1573779" /energy="-14.4" /TU="NA" /idTUdmin="U783" /TUdmin="-1" /isTUend="TRUE" CDS complement(1059203..1060420) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7934942, 14987767, 15849754, 15919996, 16850406, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934942, 14987767, 15849754, 15919996, 16850406, 24330391; Product type t : transporter" /codon_start=1 /transl_table=11 /product="proton/potassium antiporter; methylglyoxal resistance" /protein_id="NP_388866.2" /db_xref="EnsemblGenomes-Gn:BSU09850" /db_xref="EnsemblGenomes-Tr:CAB12825" /db_xref="GOA:O07536" /db_xref="InterPro:IPR006153" /db_xref="SubtiList:BG12997" /db_xref="UniProtKB/Swiss-Prot:O07536" /translation="MDHLVFEVGTALVLVAIASVIANKIKFSIIPFLIVLGMLVGPHA PKMGIIDLTFIQSSEIIEFFGRMGVLFLLFYLGLEFSVGKLIKSGKSIAVGGTIYILI NFSLGLLYGFITGFSFLEVLILAGVITISSSAIVAKVLVDLKRTANPETELILGIIMF EDIFLAVYLSVVSGLILGDATSVGSALLSILIAFGYMLLFFIAARKLPPLLNKLLDIR SNEVFIIVIFAALFFIAGFSETIHVAEAIGALLLGLVFSETEHSDRIEHLVVPFRDFF GAMFFFSFGLSIDPFSLGEAVWLALGAVILTILGNFIAGMVAGRRAGLSHKASSNIGL TIVSRGEFSIIVANLGIAGGLSATLKPFAALYVLILAILGPLVTKESKRIYRLLNKVF KWKPEVQPAKKQG*" gene complement(1059203..1060420) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" downshifts complement(1059209) /Source="Nicolas_upshifts" /id="D528" /incds=0 /nref=154 /ntot=249 /MaxReadThrough="1.74386" /MaxDrop="6.8685" /score="8.64654688" /energy="-14.4" /TU="NA" /idTUdmin="U785" /TUdmin=1 /isTUend="TRUE" CDS complement(1060427..1060924) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388867.1" /db_xref="EnsemblGenomes-Gn:BSU09860" /db_xref="EnsemblGenomes-Tr:CAB12826" /db_xref="GOA:O07535" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG12996" /db_xref="UniProtKB/Swiss-Prot:O07535" /translation="MNIKENDLPGIGKKFEIETRSHEKMTIIIHDDGRREIYRFNDRD PDELLSNISLDDSEARQIAAILGGMVYKPQALESIEMAFSDLIIEWFKVEKGAKSIGR TLGELDVRQNYDVTVIAIIKHNQEKLLNPGADSIIEENDTLVLSGERKHLKKLIHDFL SGEGV*" gene complement(1060427..1060924) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" CDS complement(1060988..1061326) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388868.1" /db_xref="EnsemblGenomes-Gn:BSU09870" /db_xref="EnsemblGenomes-Tr:CAB12827" /db_xref="GOA:O07534" /db_xref="SubtiList:BG12995" /db_xref="UniProtKB/Swiss-Prot:O07534" /translation="MRREERNMDKLLISFLLSLFMVYFPPSDVVLPSQFEASTDSYVP MSSYPQETQSAKTPSPGSMHPAELIKEYSPLAQSVRQLSVKPLDEPLINRLEKALAVP VKYQSNYLRI*" gene complement(1060988..1061326) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" promotor_-10 complement(1061338..1061357) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1061362) /Source="Nicolas_upshifts" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" promotor_-35 complement(1061371..1061378) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1061398..1061405 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1061420..1061439 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1061430 /Source="Nicolas_upshifts" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" CDS 1061491..1062258 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22961985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase / isomerase" /protein_id="NP_388869.3" /db_xref="EnsemblGenomes-Gn:BSU09880" /db_xref="EnsemblGenomes-Tr:CAB12828" /db_xref="GOA:O07533" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12994" /db_xref="UniProtKB/Swiss-Prot:O07533" /translation="MEFVQYACNGAVAEIILNRPDAHHALNEQMLSELKEAVEMAAAS EALIVLLRGSGKGFSAGGDIRMMTSEHDPDQFKRLMDTIEAVTLNLYQMKKVTIAAIH GAAAGLGLSLALCADIVLAEKNAVLAMNFIGIGLVPDGGGHYLLKKRIGEAKAKKLIW SGKKLSASEAADMGLLDGTFAGDPAEGARPIIETLLASPLLAMIETKGIFQSLQIEEL KKVLSLERSAQERMRRTKDHQEGIRAFLEKREPKFQA*" gene 1061491..1062258 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" downshifts 1062259 /Source="Nicolas_upshifts" /id="D529" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="1.78111" /MaxDrop="4.66019" /score="-8.79921781" /energy="-7.5" /TU="NA" /idTUdmin="U786" /TUdmin=0 /isTUend="TRUE" CDS complement(1062279..1062464) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097698.1" /db_xref="EnsemblGenomes-Gn:BSU09889" /db_xref="EnsemblGenomes-Tr:CAX52586" /db_xref="InterPro:IPR025544" /db_xref="UniProtKB/Swiss-Prot:C0H3Y1" /translation="MADYFLTVFDPSGNTLVNEQFEAEHEEAAKTHGEALLKEKELHS HTHRLVNAAGKLILFHR*" gene complement(1062279..1062464) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" promotor_-10 complement(1062500..1062518) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1062511) /Source="Nicolas_upshifts" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" promotor_-35 complement(1062529..1062537) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1062538..1062541 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1062556..1062575 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1062566 /Source="Nicolas_upshifts" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" CDS 1062591..1063487 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 12374817; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388870.2" /db_xref="EnsemblGenomes-Gn:BSU09890" /db_xref="EnsemblGenomes-Tr:CAB12829" /db_xref="GOA:C0SPB4" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12993" /db_xref="UniProtKB/Swiss-Prot:C0SPB4" /translation="MLTIDHVTKTFGDYKAVDGLDLDIPEQQMFGLLGANGAGKTTTF RMILGLLSITEGSISWKGRPVNYHISNKIGYLPEERGLYPKMKVRDQLVYLARLKGME KREAVKELGTWLERFNITDYENKKVEELSKGNQQKIQFISAVLHKPELLILDEPFSGL DPVNVELLKEAVISLKNSGVSILFSSHRMEHVEELCENLCILQKGKPVVQGKLKEIKR SFGKKNVTIHSDDDLRFLQSHEGILQWKETADGVKLQIANEDISQEIFAMLQGKGFIR KFELEEPSLHDIFIEKVGAVYE*" gene 1062591..1063487 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" CDS 1063480..1064739 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent exporter (ABC permease)" /protein_id="NP_388871.2" /db_xref="EnsemblGenomes-Gn:BSU09900" /db_xref="EnsemblGenomes-Tr:CAB12830" /db_xref="GOA:O07523" /db_xref="SubtiList:BG12992" /db_xref="UniProtKB/Swiss-Prot:O07523" /translation="MNKFWIMLSHTYKNKIMAKSFIISTVITVLLVLVVTNLESIISL FQGDDAKEKIAVVDETNELYPVFSKQLKAVDTDGDLDVKLSKQSEDEVTKQVKDESLD GMLIIKRDEKGTISGTYKALTISDESTYQTLQQALTQTKTAVGTAELGVSQETISSLY APVTVGQKALKEGAKSEEELGQTVGLVYIMLFVIYFSVIMYASMIAMEVATEKSSRVM EILISSMPPIQQMFAKLLGIGLVGITQLAIIIGAGSLSLKLNQKSETASSVGGFLNLT DVSATTVIYAVIFFLLGYFLYATLAAFLGSVVSRIEDVQQTITPMTLLVVAGFMIAMF GLNAPDAGFITVTSFIPFFTPMIMFLRVGMLDIPFWQAAVGIGITLLTIVILAVIGAR IYKGGVLIYGNSSAFKAIKQALRLAKN*" gene 1063480..1064739 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" downshifts 1064723 /Source="Nicolas_upshifts" /id="D530" /incds=0 /nref=19 /ntot=187 /MaxReadThrough="2.50232" /MaxDrop="3.26822" /score="8.93460501" /energy="-12.8" /TU="NA" /idTUdmin="U788" /TUdmin=0 /isTUend="TRUE" promotor_-35 1064787..1064794 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1064806..1064825 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1064811 /Source="Nicolas_upshifts" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" CDS 1064846..1066072 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA repair exonuclease" /protein_id="NP_388872.1" /db_xref="EnsemblGenomes-Gn:BSU09910" /db_xref="EnsemblGenomes-Tr:CAB12831" /db_xref="GOA:O07522" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR014576" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12991" /db_xref="UniProtKB/Swiss-Prot:O07522" /translation="MLTDLTFIHAADLHLDSPFYGISHLPEPIFARIKESTFASVRHM IDAAVREHVDFILLAGDLFDEANRSLKAQLFLKKQFERLRECGISVYVIFGNHDHLGG EWTPIEWPENVHIFSSAVPEEKSFFKEGRRIASIYGFSYQARALMENQAARYRRSTDA PFHIGMLHGTLSGSEGHDPYCPFTHDDLVKSGMDYWALGHIHKRQVLSAEHPAVIYPG NTQARHIKETGDKGYYLVHVTNGDISYEFQRAHDVLWEKAAVDVTEAKNMTALFQMVE DTFSKLRKKGSPVCVRLVLQGTAPEWLLEAPKGTLDEFLEALQEQEAEEERFVWPLRL DDETENEANLTNLDPFFGGLFEDIDRSDLSDVLEGLERHPVYRRHADRFSQEEVKEIK EQAQIILKRQLKVLDT*" gene 1064846..1066072 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" downshifts complement(1065547) /Source="Nicolas_upshifts" /id="D531" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="0.0165100000000002" /MaxDrop="3.62411" /score="-5.83060322" /energy="-15.2" /TU="NA" /idTUdmin="U787" /TUdmin="-3300" /isTUend="FALSE" CDS 1066077..1068968 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16267290, 19906728, 21517913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267290, 19906728, 21517913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATPase involved in DNA double strand break repair and recombination" /protein_id="NP_388873.1" /db_xref="EnsemblGenomes-Gn:BSU09920" /db_xref="EnsemblGenomes-Tr:CAB12832" /db_xref="GOA:O08455" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12990" /db_xref="UniProtKB/Swiss-Prot:O08455" /translation="MTALRIISLHIYQYGKFSNRTFDFSASPVQVIYGLNEAGKTTMM SFIESMLFGFPKTKKYEPKTGGVYGGVLEAEHPEYGVLKIERTKGTAEKLSVYTEKGE VKQGDVLKQLFQGTDRSLYKAIYSFDVFGLQEIHAFNRDKIGEFLLFSSLFGAEAVSK LDSRLTKESERLYKPNGRNPQLNQELETLKQLAVKLKQAEAEEAGYHQLLEEKRTLEA RLAAAETELKETAGHIRMIEGAIERKPLLNEKATLEQVIAEFPEHAGQFPADGLHQLE KYESHLHPKSAQLEALRVKMAELDKQRQKLIPDKELLAKETLIQELSAAFHMYQSWGE QLAAIQAQLRQTSAQTAAGLEQLNKTDENELLNMNTSYDYEWQLQQAVQQYVQARDRK RQLDETFELARQELEDAEKAVRAASSAILENSQRKDKEAALRAYDETQGQHQEQAKLR EQLTFFERQQAKQKKTVIAAGMLFIVLFSLLQQWIPAISFGAALIVYWLVSGKSSSRN SRETRQPMTDISPAEAEMLREALWEDDRNKQHLLTQRAALQQKEAAYERVIQQFEQWE AEMAPSFTQVERFMNELGFKEDPSFLLDAYSLMKDVKKEVKKKHELTIEAGRLKKHRR TFEERVSMLLPVNQSQDISISDALHTLRKNIEREKEIEKQKKEIETDIHYTKEQMLEL EQEIQYFHAQIEQLFAAAAAKDRDAFFAIAAISRQLKDTENKLHHVNAQLQGGYPEEL ELADSNTLSELKDKQFVENERKERLTEEIEQLRSQIALLSVKQEQLEASGMVSDLKLQ TEMQKERVKETAKKWASIQMVKQVIRNKLERHKKIELPRLLETAGEFFRPLTDGNYQT IYFSETDDSIMVMHRDGTVYHAEELSQGTCEQLYTAIRFALAVTRQGESKLPFQLDDS FVHFDQERLKRVLHVLYDLSEGGRQILYFTCHEHVKDAFHSSQIIHLVS*" gene 1066077..1068968 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" promotor_-35 1067358..1067363 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1067379..1067397 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1067385 /Source="Nicolas_upshifts" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" promotor_-35 1068976..1068981 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1068996..1069015 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1069011 /Source="Nicolas_upshifts" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" CDS 1069042..1069986 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 16267290, 19553197, 19880604" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 16267290, 19553197, 19880604; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3'-5' exonuclease" /protein_id="NP_388874.1" /db_xref="EnsemblGenomes-Gn:BSU09930" /db_xref="EnsemblGenomes-Tr:CAB12833" /db_xref="GOA:O07521" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020873" /db_xref="SubtiList:BG12989" /db_xref="UniProtKB/Swiss-Prot:O07521" /translation="MAKGIMLHEVGEQVDQYLLIKSSTKGIASNGKPFLTLMLQDQSG DIEAKLWDAKQSDEVTYAPQTIVKVVGDVHHYRGRTQLKLRNIRPVSEQENVNIDDFL ETAPIPKNEMMDTITQYIFEMKNPNIQRITRFLVKKHEAEFMDYPAATKNHHEFVSGL AYHVVSMLNLAKAIADLYPSLDRDLLYAGVILHDLGKVKELSGPVSTSYTVEGNLLGH ISIMVTELSKAAEELQIDSEEVLILQHLILSHHGKAEWGSPKPPMVKEAEILHYIDNL DAKMNMMDRALERVKPGEYTERVFALENRSFYKPTFHK*" gene 1069042..1069986 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" downshifts 1069964 /Source="Nicolas_upshifts" /id="D532" /incds=0 /nref=183 /ntot=261 /MaxReadThrough="3.02818" /MaxDrop="5.88173" /score="6.06919899" /energy="-15.8" /TU="NA" /idTUdmin="U789" /TUdmin=5 /isTUend="TRUE" promotor_-35 1070045..1070050 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1070066..1070084 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1070069 /Source="Nicolas_upshifts" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" CDS 1070111..1070323 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523133; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="sporulation factor" /protein_id="NP_388875.1" /db_xref="EnsemblGenomes-Gn:BSU09940" /db_xref="EnsemblGenomes-Tr:CAB12834" /db_xref="GOA:O07520" /db_xref="InterPro:IPR025428" /db_xref="SubtiList:BG12988" /db_xref="UniProtKB/Swiss-Prot:O07520" /translation="MLFFPWWVYLCIVGIIFSAYKLVAAAKEEEKVDQAFIEKEGQIY MERMEKERERRSSQQHEEENQNHSIA*" gene 1070111..1070323 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" downshifts 1070316 /Source="Nicolas_upshifts" /id="D533" /incds=0 /nref=8 /ntot=158 /MaxReadThrough="2.03283" /MaxDrop="6.60832" /score="62.1892984" /energy="-22" /TU="NA" /idTUdmin="U792" /TUdmin=5 /isTUend="TRUE" downshifts complement(1070354) /Source="Nicolas_upshifts" /id="D534" /incds=0 /nref=97 /ntot=260 /MaxReadThrough="0.90997" /MaxDrop="9.00938" /score="52.3375501" /energy="-22" /TU="NA" /idTUdmin="U793" /TUdmin=11 /isTUend="TRUE" CDS complement(1070364..1071242) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12634326, 12682299, 14976191, 16516208, 25525259, 26711778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12634326, 12682299, 14976191, 16516208, 25525259, 26711778; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molecular chaperone lipoprotein" /protein_id="NP_388876.1" /db_xref="EnsemblGenomes-Gn:BSU09950" /db_xref="EnsemblGenomes-Tr:CAB12835" /db_xref="GOA:P24327" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR023059" /db_xref="InterPro:IPR027304" /db_xref="PDB:1ZK6" /db_xref="PDB:4WO7" /db_xref="SubtiList:BG10464" /db_xref="UniProtKB/Swiss-Prot:P24327" /translation="MKKIAIAAITATSILALSACSSGDKEVIAKTDAGDVTKGELYTN MKKTAGASVLTQLVQEKVLDKKYKVSDKEIDNKLKEYKTQLGDQYTALEKQYGKDYLK EQVKYELLTQKAAKDNIKVTDADIKEYWEGLKGKIRASHILVADKKTAEEVEKKLKKG EKFEDLAKEYSTDSSASKGGDLGWFAKEGQMDETFSKAAFKLKTGEVSDPVKTQYGYH IIKKTEERGKYDDMKKELKSEVLEQKLNDNAAVQEAVQKVMKKADIEVKDKDLKDTFN TSSTSNSTSSSSSNSK*" gene complement(1070364..1071242) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" downshifts complement(1070552) /Source="Nicolas_upshifts" /id="D535" /incds=1 /nref=10 /ntot=127 /MaxReadThrough="7.54458" /MaxDrop="3.5906" /score="52.3375501" /energy="-22" /TU="U793" /idTUdmin="U793" /TUdmin="-187" /isTUend="FALSE" promotor_-10 complement(1071280..1071299) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1071304) /Source="Nicolas_upshifts" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" promotor_-35 complement(1071313..1071320) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1071340..1071349 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1071361 /Source="Nicolas_upshifts" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" promotor_-10 1071362..1071381 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1071398..1071412) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1071399) /Source="Nicolas_upshifts" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1071402..1071488 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:20156992, 21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20156992, 21670523; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="spore assembly and germination protein" /protein_id="YP_003097699.1" /db_xref="EnsemblGenomes-Gn:BSU09958" /db_xref="EnsemblGenomes-Tr:CAX52587" /db_xref="GOA:C0H3Y2" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Y2" /translation="MSGGYSNGFALLVVLFILLIIVGAAYIY*" gene 1071402..1071488 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" promotor_-35 complement(1071421..1071425) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1071489..1071740 /Source="Nicolas_S_feature" /locus_tag="new_1071489_1071740" /HighExp="S8, S7, S6, BT, G/S, B36, Pyr, S5, B60, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S347" CDS 1071613..1071699 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore and germination protein" /protein_id="YP_009513948.1" /db_xref="EnsemblGenomes-Gn:BSU09959" /db_xref="EnsemblGenomes-Tr:CCQ48595" /db_xref="GOA:L8EBJ6" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/TrEMBL:L8EBJ6" /translation="MGEVFAGGFALLVVLFILLIIIGASWLY*" gene 1071613..1071699 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" downshifts 1071697 /Source="Nicolas_upshifts" /id="D536" /incds=0 /nref=28 /ntot=50 /MaxReadThrough="4.67734" /MaxDrop="4.7906" /score="14.3797211" /energy="-17.6" /TU="U794" /idTUdmin="U794" /TUdmin="-506" /isTUend="FALSE" S_feature complement(1071709..1071971) /Source="Nicolas_S_feature" /locus_tag="new_1071709_1071971_c" /HighExp="LBGtran, LBGstat, LPhT, LBGexp, HPh, dia15, T0.30H, dia0, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S348" S_feature 1071742..1072225 /Source="Nicolas_S_feature" /locus_tag="new_1071742_1072225" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, Glucon, G/S, C90" /AntisenseName="yhaJ" /AntisenseCor="-0.22462434208606599" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S349" downshifts complement(1071752) /Source="Nicolas_upshifts" /id="D537" /incds=0 /nref=153 /ntot=265 /MaxReadThrough="1.32339" /MaxDrop="6.55635" /score="34.7913848" /energy="-17.6" /TU="NA" /idTUdmin="U796" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(1071964..1071983) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1071971) /Source="Nicolas_upshifts" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" S_feature complement(1071973..1072041) /Source="Nicolas_S_feature" /locus_tag="new_1071973_1072041_c" /HighExp="Paraq, G180, C30, LBGexp, Oxctl, G135, Lbexp, Heat, G150, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29568499999999998" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S350" promotor_-35 complement(1071997..1072002) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1072042..1072560) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009, 21670523, 25651892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme" /protein_id="NP_388878.2" /db_xref="EnsemblGenomes-Gn:BSU09965" /db_xref="EnsemblGenomes-Tr:CAB12837" /db_xref="GOA:O07518" /db_xref="InterPro:IPR021683" /db_xref="SubtiList:BG12986" /db_xref="UniProtKB/Swiss-Prot:O07518" /translation="MNCWKTINLMKDYGAVRIILTAVCFMILVFISTFLAFELLRPGT SLSDEYVSLFGGLLVVILFVHKVIHVLPIICKKRKIEKKFYILRMRTWKRIPKTTMLI SLVSPFLLITPVLFYAALAFPNHAHYFCMISGIHAGYCLPDFLLALKLIKAPKTAFID QEADGLDILVEK*" gene complement(1072042..1072560) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" promotor_-35 1072347..1072355 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1072367..1072385 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1072380 /Source="Nicolas_upshifts" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1072591..1072610) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1072609) /Source="Nicolas_upshifts" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" promotor_-35 complement(1072626..1072632) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1072709..1072712 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1072727..1072746 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1072732 /Source="Nicolas_upshifts" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" CDS 1072768..1073109 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388879.1" /db_xref="EnsemblGenomes-Gn:BSU09980" /db_xref="EnsemblGenomes-Tr:CAB12838" /db_xref="InterPro:IPR015058" /db_xref="InterPro:IPR035945" /db_xref="PDB:1SED" /db_xref="SubtiList:BG12985" /db_xref="UniProtKB/Swiss-Prot:O07517" /translation="MDSMDHRIERLEYYIQLLVKTVDMDRYPFYALLIDKGLSKEEGE AVMRICDELSEELATQKAQGFVTFDKLLALFAGQLNEKLDVHETIFALYEQGLYQELM EVFIDIMKHFD*" gene 1072768..1073109 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" S_feature complement(1072963..1073105) /Source="Nicolas_S_feature" /locus_tag="new_1072963_1073105_c" /HighExp="BC, S1, Sw, S2, S3, S8, S5, S4, S6, S7" /AntisenseName="yhaI" /AntisenseCor="5.4889858269512502E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S351" downshifts complement(1073006) /Source="Nicolas_upshifts" /id="D538" /incds=1 /nref=39 /ntot=209 /MaxReadThrough="2.89899" /MaxDrop="4.77791" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-374" /isTUend="FALSE" CDS complement(1073106..1073717) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of extracellular protease production, sporulation and bacilysin production (MarR family)" /protein_id="NP_388880.1" /db_xref="EnsemblGenomes-Gn:BSU09990" /db_xref="EnsemblGenomes-Tr:CAB12839" /db_xref="GOA:P11065" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR023488" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FXA" /db_xref="SubtiList:BG10659" /db_xref="UniProtKB/Swiss-Prot:P11065" /translation="MNRVEPPYDVKEALVFTQKMAQLSKALWKSIEKDWQQWLKPYDL NINEHHILWIAYQLNGASISEIAKFGVMHVSTAFNFSKKLEERGYLRFSKRLNDKRNT YVQLTEEGTEVFWSLLEEFDPTRNAVFKGSQPLYHLFGKFPEVAEMMCMIRHIYGDDF MEIFETSLTNIDNDFESVNGKLKKKAKDSAADEPAEELEPVNS*" gene complement(1073106..1073717) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" S_feature 1073110..1073875 /Source="Nicolas_S_feature" /locus_tag="new_1073110_1073875" /HighExp="Lbstat, Etha, T0.30H, Gly, M0t90, M40t90, M40t45, M0t45, H2O2, dia15" /AntisenseName="scoC" /AntisenseCor="-0.46322626361720198" /AntisenseRegPval="-15" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S352" downshifts complement(1073182) /Source="Nicolas_upshifts" /id="D539" /incds=1 /nref=1 /ntot=81 /MaxReadThrough="5.81117" /MaxDrop="2.1632" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-550" /isTUend="FALSE" promotor_-35 1073713..1073717 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1073725..1073738 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1073737 /Source="Nicolas_upshifts" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1073742..1073761) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-10" upshifts complement(1073765) /Source="Nicolas_upshifts" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" promotor_-35 complement(1073776..1073779) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-35" downshifts 1073832 /Source="Nicolas_upshifts" /id="D540" /incds=0 /nref=1 /ntot=124 /MaxReadThrough="3.007" /MaxDrop="2.86547" /score="17.8486533" /energy="-7.1" /TU="U799,U800" /idTUdmin="U799" /TUdmin="-22" /isTUend="TRUE" CDS complement(1073895..1074251) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11429463; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein; acid tolerance protein" /protein_id="NP_388881.1" /db_xref="EnsemblGenomes-Gn:BSU10000" /db_xref="EnsemblGenomes-Tr:CAB12840" /db_xref="GOA:O07516" /db_xref="InterPro:IPR024623" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12984" /db_xref="UniProtKB/Swiss-Prot:O07516" /translation="MASGRSLLTGLFVGGIIGGAAVLLTAPSSGKQLREKMKTNYDSF EETIKRLKSDGLALKDQLIKAAKESTDVIKDVGGELQTSIKKWQEEIKPHQQDLQKEI ADIEEKIRQLEKTLQN*" gene complement(1073895..1074251) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" downshifts complement(1073899) /Source="Nicolas_upshifts" /id="D541" /incds=0 /nref=254 /ntot=287 /MaxReadThrough="1.65317" /MaxDrop="7.37381" /score="10.8990112" /energy="-7.9" /TU="NA" /idTUdmin="U804" /TUdmin=9 /isTUend="TRUE" promotor_-35 1074328..1074333 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1074334..1074353) /Source="Nicolas_upshift_promotors" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1074348) /Source="Nicolas_upshifts" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" promotor_-10 1074349..1074367 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1074349 /Source="Nicolas_upshifts" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" S_feature complement(1074350..1074613) /Source="Nicolas_S_feature" /locus_tag="new_1074350_1074613_c" /HighExp="Etha, Salt, HiTm, Heat, Diami, Sw, Gly, S1, MG 10, MG 60" /AntisenseName="yhzF" /AntisenseCor="-0.69425315975357205" /AntisenseRegPval="-39.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S353" CDS 1074381..1074572 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="membrane protein of unknown function" /protein_id="YP_003097700.1" /db_xref="EnsemblGenomes-Gn:BSU10009" /db_xref="EnsemblGenomes-Tr:CAX52588" /db_xref="GOA:C0H3Y3" /db_xref="UniProtKB/Swiss-Prot:C0H3Y3" /translation="MSVFLIVLSCITLAFASGAVYYIKLLSQAASYPPKRVIRQKALV CSTGTAFTLCLIFFTKLLA*" gene 1074381..1074572 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" S_feature 1074573..1076008 /Source="Nicolas_S_feature" /locus_tag="new_1074573_1076008" /HighExp="S3, S8, S4, S6, S7, T5.0H, C30, S5, T4.0H, T3.30H" /AntisenseName="trpP" /AntisenseCor="-0.20038256384636899" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S354" CDS complement(1074646..1075164) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735881, 14702295, 15849754, 16850406, 16879415, 17114263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735881, 14702295, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="tryptophan transporter or sensor" /protein_id="NP_388882.2" /db_xref="EnsemblGenomes-Gn:BSU10010" /db_xref="EnsemblGenomes-Tr:CAB12841" /db_xref="GOA:O07515" /db_xref="InterPro:IPR031360" /db_xref="SubtiList:BG12983" /db_xref="UniProtKB/Swiss-Prot:O07515" /translation="MKTKELVIMALFAAIGAALHSIIPPFLGGMKPDMMLIMMFMGIL LFPRVQNVLVIGIVTGIISALTTAFPAGQIPNIIDKPVSAFLFFSLFLLFRKSRKTGA AAVLTVIGTILSGIVFLSSALLIVGLPGGFAALFAAVVLPAAVLNTISMIIIYPIVQT ILRRSSFMEAAK*" gene complement(1074646..1075164) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" downshifts complement(1074658) /Source="Nicolas_upshifts" /id="D542" /incds=0 /nref=105 /ntot=253 /MaxReadThrough="6.00956" /MaxDrop="4.62812" /score="24.5949542" /energy="-12.8" /TU="U804,U805,U806" /idTUdmin="U804" /TUdmin="-750" /isTUend="FALSE" S_feature complement(1075165..1075252) /Source="Nicolas_S_feature" /locus_tag="new_1075165_1075252_c" /HighExp="C90, B60, S1, GM 15, MG 45, MG-0.2, Etha, Lbtran, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S355" promotor_-10 complement(1075244..1075263) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1075252) /Source="Nicolas_upshifts" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" promotor_-35 complement(1075277..1075284) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1075289..1076368) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" /EC_number="2.6.1.52" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4337849, 16233211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4337849, 16233211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine aminotransferase" /protein_id="NP_388883.1" /db_xref="EnsemblGenomes-Gn:BSU10020" /db_xref="EnsemblGenomes-Tr:CAB12842" /db_xref="GOA:P80862" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR022278" /db_xref="SubtiList:BG12673" /db_xref="UniProtKB/Swiss-Prot:P80862" /translation="MERTTNFNAGPAALPLEVLQKAQKEFIDFNESGMSVMELSHRSK EYEAVHQKAKSLLIELMGIPEDYDILFLQGGASLQFSMLPMNFLTPEKTAHFVMTGAW SEKALAETKLFGNTSITATSETDNYSYIPEVDLTDVKDGAYLHITSNNTIFGTQWQEF PNSPIPLVADMSSDILSRKIDVSKFDVIYGGAQKNLGPSGVTVVIMKKSWLQNENANV PKILKYSTHVKADSLYNTPPTFAIYMLSLVLEWLKENGGVEAVEQRNEQKAQVLYSCI DESNGFYKGHARKDSRSRMNVTFTLRDDELTKTFVQKAKDAKMIGLGGHRSVGGCRAS IYNAVSLEDCEKLAAFMKKFQQENE*" gene complement(1075289..1076368) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" misc_feature complement(1076407..1076426) /Source="Nicolas_upshift_promotors" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1076418) /Source="Nicolas_upshifts" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" S_feature complement(1076420..1076501) /Source="Nicolas_S_feature" /locus_tag="new_1076420_1076501_c" /HighExp="Etha, dia15, H2O2, LBGtran, G135, G180, dia5, G150, Lbexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S356" CDS complement(1076515..1076952) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" /EC_number="3.6.1.29" /EC_number="3.6.1.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579061, 15703176, 16934294, 17217311, 26181368, 28516732; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous Hit-family phosphohydrolase, adenosine phosphoramidase" /protein_id="NP_388884.1" /db_xref="EnsemblGenomes-Gn:BSU10030" /db_xref="EnsemblGenomes-Tr:CAB12843" /db_xref="GOA:O07513" /db_xref="InterPro:IPR001310" /db_xref="InterPro:IPR011146" /db_xref="InterPro:IPR019808" /db_xref="InterPro:IPR036265" /db_xref="PDB:1Y23" /db_xref="SubtiList:BG12607" /db_xref="UniProtKB/Swiss-Prot:O07513" /translation="MHCAENCIFCKIIAGDIPSAKVYEDEHVLAFLDISQVTKGHTLV IPKTHIENVYEFTDELAKQYFHAVPKIARAIRDEFEPIGLNTLNNNGEKAGQSVFHYH MHIIPRYGKGDGFGAVWKTHADDYKPEDLQNISSSIAKRLASS*" gene complement(1076515..1076952) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" downshifts complement(1076546) /Source="Nicolas_upshifts" /id="D543" /incds=0 /nref=187 /ntot=248 /MaxReadThrough="4.31506" /MaxDrop="5.61862" /score="-0.366845751" /energy="-8.6" /TU="U806" /idTUdmin="U807" /TUdmin=4 /isTUend="TRUE" promotor_-10 complement(1076985..1077004) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1076999) /Source="Nicolas_upshifts" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" downshifts 1077002 /Source="Nicolas_upshifts" /id="D544" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.3752" /MaxDrop="3.02008" /score="-3.56654132" /energy="-13.3" /TU="NA" /idTUdmin="U803" /TUdmin=1034 /isTUend="FALSE" promotor_-35 complement(1077018..1077025) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1077024..1077320) /Source="Nicolas_S_feature" /locus_tag="new_1077024_1077320_c" /HighExp="S7, S8, S6, S5, BT, ferm, nit, G/S, S4, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S357" downshifts complement(1077067) /Source="Nicolas_upshifts" /id="D545" /incds=0 /nref=40 /ntot=72 /MaxReadThrough="3.07347" /MaxDrop="7.69075" /score="9.88617558" /energy="-14.2" /TU="U807" /idTUdmin="U807" /TUdmin="-517" /isTUend="FALSE" promotor_-10 complement(1077318..1077329) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1077324) /Source="Nicolas_upshifts" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" promotor_-35 complement(1077344..1077350) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1077380..1077387 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1077401..1077420 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1077410 /Source="Nicolas_upshifts" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" CDS 1077440..1078183 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 11807061, 18599827, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 11807061, 18599827, 26735940; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein)" /protein_id="NP_388885.1" /db_xref="EnsemblGenomes-Gn:BSU10040" /db_xref="EnsemblGenomes-Tr:CAB12844" /db_xref="GOA:P55339" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11516" /db_xref="UniProtKB/Swiss-Prot:P55339" /translation="MSLLSVKDLTGGYTRNPVLKNVSFTLEPNQIVGLIGLNGAGKST TIRHIIGLMDPHKGSIELNGKTFAEDPEGYRSQFTYIPETPVLYEELTLMEHLELTAM AYGLSKETMEKRLPPLLKEFRMEKRLKWFPAHFSKGMKQKVMIMCAFLAEPALYIIDE PFLGLDPLAINALLERMNEAKKGGASVLMSTHILATAERYCDSFIILHNGEVRARGTL SELREQFGMKDAALDDLYLELTKEDAGHE*" gene 1077440..1078183 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" CDS 1078176..1079402 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease subunit)" /protein_id="NP_388886.1" /db_xref="EnsemblGenomes-Gn:BSU10050" /db_xref="EnsemblGenomes-Tr:CAB12845" /db_xref="GOA:P55340" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG11517" /db_xref="UniProtKB/Swiss-Prot:P55340" /translation="MNNMLDIWQSRLQEHIKETRTYMKYMLNDHLVIVLIFFLAGAAS WYSKWIRDIPAHFPSFWVMAVLFSLVLTSSYVRTLLKEADLVFLLPLEAKMEPYLKQA FVYSYVSQLFPLIALSIVAMPLYFAVTPGASLVSYAAVFVQLLLLKAWNQVMEWRTTF QNDRSMKRMDVIIRFAANTLVLYFVFQSVYMYALLVYVIMAVLYLYMSSAAKRKTFKW ESHIESELRRKQRFYRIANLFTDVPHLRKQAKRRAYLDFLLRLVPFEQRKTFAYMFTR AFLRSSDYLGILVRLTIVFALIIMYVSASPLIAAVLTVFAIFITGIQLLPLFGHFDHL ALQELYPVQKETKLKSYFSLLKTALSIQALLMSVASAYAAGLTGFLYALIGSAVLIFV VLPAYMTTRLKKHGKL*" gene 1078176..1079402 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" promotor_-10 complement(1078735..1078753) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1078750) /Source="Nicolas_upshifts" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1078769..1078774) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1079422..1080132 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8581172, 10027970; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388887.1" /db_xref="EnsemblGenomes-Gn:BSU10060" /db_xref="EnsemblGenomes-Tr:CAB12846" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG11518" /db_xref="UniProtKB/Swiss-Prot:P55341" /translation="MTDNQLLMQEALEWKMHFLRKDSMFERFSKRVQTKVNERIPEKI HTVVTESVKKMVEATMAGSNIITYKKDTSALSLSEKNELAKKTIVSYQKVAAAEGVGT GAGGIFLSIADFPLLLSIKMKCLFTLSSIYGFDVKDAQERIFLLLVFQLAFSSDDGRK SLFSVIENWETEKKSIDWRVFQQEYRDYIDVVKLFQLLPGVGAAVGGIANYKLLAQLG ETARHVFHLRILKETAGE*" gene 1079422..1080132 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" downshifts 1080096 /Source="Nicolas_upshifts" /id="D546" /incds=0 /nref=78 /ntot=231 /MaxReadThrough="1.36097" /MaxDrop="4.78417" /score="28.5337351" /energy="-14.6" /TU="NA" /idTUdmin="U808" /TUdmin="-8" /isTUend="TRUE" CDS complement(1080150..1081340) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" /EC_number="3.5.1.-" /experiment="publication(s) with functional evidences, PMID:23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl amino acid acetylase, promiscuous activity" /protein_id="NP_388888.2" /db_xref="EnsemblGenomes-Gn:BSU10070" /db_xref="EnsemblGenomes-Tr:CAB12847" /db_xref="GOA:O07598" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12982" /db_xref="UniProtKB/Swiss-Prot:O07598" /translation="MSISTLQKEINKQLDGCFEEMVEIRRHFHMYPELSFQEEKTAAF IASYYESLGVPIRTNVGGRGVLANIEGSEPGPTVALRADFDALPIQDEKDVPYASKVP GVMHACGHDGHTAALLAVAKVLHQNRHELKGTFVMIHQHAEEYYPGGAKPMIDDGCLE NTDVIFGTHLWATEPLGTILCRPGAVMAAADRFTIKVFGKGGHGAHPHDTKDAVLIGS QIVSSLQHIVSRKVNPIQSAVISTGSFIADNPFNVIADQAVLIGTARSFDENVRDILE KEIEAVVKGICSMHGASYEYTYEQGYPAVVNHPAETNHLVSTAKNTEGVQQVIDGEPQ MGGEDFAYYLQNVKGTFFFTGAAPEQPERVYSHHHPKFDINEKAMLTAAKVLAGAAIT YHQL*" gene complement(1080150..1081340) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" downshifts complement(1080160) /Source="Nicolas_upshifts" /id="D547" /incds=0 /nref=11 /ntot=162 /MaxReadThrough="3.12546" /MaxDrop="4.15559" /score="-4.78420642" /energy="-14.6" /TU="U810" /idTUdmin="U811" /TUdmin="-2" /isTUend="TRUE" downshifts complement(1080225) /Source="Nicolas_upshifts" /id="D548" /incds=1 /nref=25 /ntot=206 /MaxReadThrough="4.92378" /MaxDrop="3.21645" /score="-4.78420642" /energy="-14.6" /TU="U810,U811" /idTUdmin="U811" /TUdmin="-67" /isTUend="FALSE" promotor_-10 complement(1081364..1081383) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1081385) /Source="Nicolas_upshifts" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" promotor_-35 complement(1081397..1081402) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1081413..1082804) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 12107147; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_388889.1" /db_xref="EnsemblGenomes-Gn:BSU10080" /db_xref="EnsemblGenomes-Tr:CAB12848" /db_xref="GOA:O07599" /db_xref="SubtiList:BG13047" /db_xref="UniProtKB/Swiss-Prot:O07599" /translation="MMEVGILPVHVLYVFFIGAIILFMLLRKDTTFISLFGIFIISLW ASHSLSASVSSLFHSFIYAAGELLPTIFIICFIVSMSDLLTKTGINEAMISPFASLVR GPVTAYWLIGGLMFAISLFFWPSPGVALIGAVLLPAAARAGLTPLAAAMAMNLFGHGF ALSGDFVIQAAPKLTADAAGIPVGDVVSASIPLVLIMGVTTTTAAFIMIQRERKKQEH PTSFSPVLSGEQDNSLYLPKRLRSILAFLIPLAFLADIACMLLFNLQGNDATALIGGS AICILFTVHFFVYKHKGLEKITGYFIDGFKFGFKVFGPVIPIAAFFYLGDSGYESILG TSLPKGSHGIVNDLGIALSHMMPMSKELAATALTAAGAITGLDGSGFSGISLAGSIAK LFSSALHADPAILTALGQISAIWVGGGTLVPWALIPAAAICKVDPFELARKNFIPVAI GLLVTTLAAVMML*" gene complement(1081413..1082804) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" promotor_-10 complement(1082815..1082834) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1082820) /Source="Nicolas_upshifts" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" promotor_-35 complement(1082847..1082856) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1082870..1083184) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388890.1" /db_xref="EnsemblGenomes-Gn:BSU10090" /db_xref="EnsemblGenomes-Tr:CAB12849" /db_xref="SubtiList:BG10426" /db_xref="UniProtKB/Swiss-Prot:P38048" /translation="MKHTCPVCGFKDWLNRHMIMKAIILMKSARAAVFSSDLMSTRCS TRITHIEPSESIIAYRKNWLAEGCVIFSPECFPKHLQKANRGLRHHLIEQLKQINVHL PS*" gene complement(1082870..1083184) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" CDS complement(1083229..1083729) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" /EC_number="1.14.99.48" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21873409, 22531134, 24582752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21873409, 22531134, 24582752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heme-degrading monooxygenase" /protein_id="NP_388891.1" /db_xref="EnsemblGenomes-Gn:BSU10100" /db_xref="EnsemblGenomes-Tr:CAB12850" /db_xref="GOA:P38049" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:4OZ5" /db_xref="SubtiList:BG10427" /db_xref="UniProtKB/Swiss-Prot:P38049" /translation="MKVYITYGTADFLKTIVQKHPSENILLMQGQENAILIHETNGDT VFQAPHAYEVIDQVGEIKHPGFAVLNNIAVTQEGRPLFENRFKNRAGKVENEPGFEAI RVLRPLDSDTYVILTLWETESAFQDWQQSGSYKEAHKKRDTSAGIDTTSIFSRPSYVT TYFAVE*" gene complement(1083229..1083729) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" downshifts complement(1083256) /Source="Nicolas_upshifts" /id="D549" /incds=0 /nref=145 /ntot=254 /MaxReadThrough="3.45185" /MaxDrop="5.6374" /score="15.5142908" /energy="-14.8" /TU="U812" /idTUdmin="U812" /TUdmin="-546" /isTUend="FALSE" promotor_-10 complement(1083742..1083761) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1083744..1083748 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1083763) /Source="Nicolas_upshifts" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" promotor_-10 1083764..1083783 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1083765 /Source="Nicolas_upshifts" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" promotor_-35 complement(1083778..1083779) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1083796..1083802 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1083817..1083828 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1083822 /Source="Nicolas_upshifts" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" CDS 1083851..1085995 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8335642, 11567005, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8335642, 11567005, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2C (1F class) required for spore germination" /protein_id="NP_388892.2" /db_xref="EnsemblGenomes-Gn:BSU10110" /db_xref="EnsemblGenomes-Tr:CAB12851" /db_xref="GOA:P38050" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10428" /db_xref="UniProtKB/Swiss-Prot:P38050" /translation="MFKIKKKKLFIPIIILVLTAFLALIGYISIIFLGHYVIDEKKLI LHASSKIVDQNGDEVASLYTENREPVSINEIPKQVREAFIAVEDKRFYEHHGIDAKSV GRAVYRDILAGGKVEGGSTITQQLAKNIFLTHDKTFLRKTKEVIIAINLERDYSKDKL LEMYLNQLYFGHGVYGIQAASHYYFNKEVKDLTVSEGAVLAAIPKAPSTYSPILHPDK NKERRDTILGMMNDQGYISAKEAVTAQGRTLGLHVKKQSETPWFDSYIDLVIKEAEDK YSISGEQLLQGGYTIKVPLDSKLQKTAYQVMKEGSYYPGTDQNAEGSAVFINNKTGGV EAAIGGRDYTSKGYNRVTAVRQPGSTFKPLAVYGPAMQEKKFKPYSLLKDELQSYGDY TPKNYDSRYEGEVTMSDAITYSKNAPAVWTLNEIGVETGKSYLKANGIDIPDEGLALA LGGLEKGVSPLQLAGAFHTFAANGTYTEPFFISSIIDEDGETIADHKEEGKRVFSKQT SWNMTRMLQQVVKKGTATSGTYHGDLAGKTGSTSYTGVSGATKDAWFAGYTPKITGAV WMGYDKTDQNHYLKAGSSYPTRLFKDILTQAGETGHVFTKPKNVKELESPIELKPVKT LTADYTFKAAGLFTIELKWDAQEDDRAVYRIYVNKDGEETLLDSVEGKGSYEIPYANL FSGASYKIVPYNTQTKREGEGTDYVQPKLFSS*" gene 1083851..1085995 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" promotor_-10 complement(1083895..1083906) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1083898) /Source="Nicolas_upshifts" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1083920..1083926) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1086032..1086038 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1086052..1086071 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1086062 /Source="Nicolas_upshifts" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" CDS 1086117..1087178 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" /EC_number="4.1.1.37" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 17122346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 17122346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III decarboxylase" /protein_id="NP_388893.1" /db_xref="EnsemblGenomes-Gn:BSU10120" /db_xref="EnsemblGenomes-Tr:CAB12852" /db_xref="GOA:P32395" /db_xref="InterPro:IPR000257" /db_xref="InterPro:IPR006361" /db_xref="PDB:2INF" /db_xref="SubtiList:BG10429" /db_xref="UniProtKB/Swiss-Prot:P32395" /translation="MSKRETFNETFLKAARGEKADHTPVWYMRQAGRSQPEYRKLKEK YGLFEITHQPELCAYVTRLPVEQYGVDAAILYKDIMTPLPSIGVDVEIKNGIGPVIDQ PIRSLADIEKLGQIDPEQDVPYVLETIKLLVNEQLNVPLIGFSGAPFTLASYMIEGGP SKNYNKTKAFMYSMPDAWNLLMSKLADMIIVYVKAQIEAGAKAIQIFDSWVGALNQAD YRTYIKPVMNRIFSELAKENVPLIMFGVGASHLAGDWHDLPLDVVGLDWRLGIDEARS KGITKTVQGNLDPSILLAPWEVIEQKTKEILDQGMESDGFIFNLGHGVFPDVSPEVLK KLTAFVHEYSQNKKMGQYS*" gene 1086117..1087178 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" CDS 1087250..1088182 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" /EC_number="4.99.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferrochelatase" /protein_id="NP_388894.1" /db_xref="EnsemblGenomes-Gn:BSU10130" /db_xref="EnsemblGenomes-Tr:CAB12853" /db_xref="GOA:P32396" /db_xref="InterPro:IPR001015" /db_xref="InterPro:IPR019772" /db_xref="InterPro:IPR033644" /db_xref="InterPro:IPR033659" /db_xref="PDB:1AK1" /db_xref="PDB:1C1H" /db_xref="PDB:1C9E" /db_xref="PDB:1DOZ" /db_xref="PDB:1FJI" /db_xref="PDB:1LD3" /db_xref="PDB:1N0I" /db_xref="PDB:2AC2" /db_xref="PDB:2AC4" /db_xref="PDB:2H1V" /db_xref="PDB:2H1W" /db_xref="PDB:2HK6" /db_xref="PDB:2Q2N" /db_xref="PDB:2Q2O" /db_xref="PDB:2Q3J" /db_xref="PDB:3GOQ" /db_xref="PDB:3M4Z" /db_xref="SubtiList:BG10430" /db_xref="UniProtKB/Swiss-Prot:P32396" /translation="MSRKKMGLLVMAYGTPYKEEDIERYYTHIRRGRKPEPEMLQDLK DRYEAIGGISPLAQITEQQAHNLEQHLNEIQDEITFKAYIGLKHIEPFIEDAVAEMHK DGITEAVSIVLAPHFSTFSVQSYNKRAKEEAEKLGGLTITSVESWYDEPKFVTYWVDR VKETYASMPEDERENAMLIVSAHSLPEKIKEFGDPYPDQLHESAKLIAEGAGVSEYAV GWQSEGNTPDPWLGPDVQDLTRDLFEQKGYQAFVYVPVGFVADHLEVLYDNDYECKVV TDDIGASYYRPEMPNAKPEFIDALATVVLKKLGR*" gene 1087250..1088182 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" CDS 1088197..1089609 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" /EC_number="1.3.3.4" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9217019, 9784236, 10498703, 20543190" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9217019, 9784236, 10498703, 20543190; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous protoporphyrinogen IX and coproporphyrinogen III oxidase" /protein_id="NP_388895.1" /db_xref="EnsemblGenomes-Gn:BSU10140" /db_xref="EnsemblGenomes-Tr:CAB12854" /db_xref="GOA:P32397" /db_xref="InterPro:IPR002937" /db_xref="InterPro:IPR004572" /db_xref="InterPro:IPR036188" /db_xref="PDB:3I6D" /db_xref="SubtiList:BG10431" /db_xref="UniProtKB/Swiss-Prot:P32397" /translation="MSDGKKHVVIIGGGITGLAAAFYMEKEIKEKNLPLELTLVEASP RVGGKIQTVKKDGYIIERGPDSFLERKKSAPQLVKDLGLEHLLVNNATGQSYVLVNRT LHPMPKGAVMGIPTKIAPFVSTGLFSLSGKARAAMDFILPASKTKDDQSLGEFFRRRV GDEVVENLIEPLLSGIYAGDIDKLSLMSTFPQFYQTEQKHRSLILGMKKTRPQGSGQQ LTAKKQGQFQTLSTGLQTLVEEIEKQLKLTKVYKGTKVTKLSHSGSCYSLELDNGVTL DADSVIVTAPHKAAAGMLSELPAISHLKNMHSTSVANVALGFPEGSVQMEHEGTGFVI SRNSDFAITACTWTNKKWPHAAPEGKTLLRAYVGKAGDESIVDLSDNDIINIVLEDLK KVMNINGEPEMTCVTRWHESMPQYHVGHKQRIKELREALASAYPGVYMTGASFEGVGI PDCIDQGKAAVSDALTYLFS*" gene 1088197..1089609 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" downshifts 1088200 /Source="Nicolas_upshifts" /id="D550" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="7.68191" /MaxDrop="2.667" /score="28.7532434" /energy="-11.6" /TU="U813,U816" /idTUdmin="U814" /TUdmin=0 /isTUend="TRUE" downshifts 1089586 /Source="Nicolas_upshifts" /id="D551" /incds=0 /nref=195 /ntot=254 /MaxReadThrough="2.9859" /MaxDrop="6.7703" /score="28.7532434" /energy="-11.6" /TU="NA" /idTUdmin="U813" /TUdmin=0 /isTUend="TRUE" promotor_-35 1089670..1089677 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1089691..1089710 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1089696 /Source="Nicolas_upshifts" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" CDS 1089755..1090330 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15944459, 23695570; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown target" /protein_id="NP_388896.1" /db_xref="EnsemblGenomes-Gn:BSU10150" /db_xref="EnsemblGenomes-Tr:CAB12855" /db_xref="GOA:P32398" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10432" /db_xref="UniProtKB/Swiss-Prot:P32398" /translation="MSIDRKKLILEAATKSFTQFGYKATTMDLVAKLANVGKGTIYTF FKNKEELFDEIFTTLLKEMKQKADEAMEPSLPFHENVHRALFAILEFRKTHQLTIKIF QENAEIGTMAVQEVIQKMERSILSYIKSKIEDGIKSGAIKPCDPELTAFVMLKLYIAL IFDWEKQHPPLDKETIAGLLELYVVKGLSAN*" gene 1089755..1090330 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" promotor_-35 1090074..1090077 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1090092 /Source="Nicolas_upshifts" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" promotor_-10 1090094..1090113 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1090331..1090400 /Source="Nicolas_S_feature" /locus_tag="new_1090331_1090400" /HighExp="G135, G150, G180, BI, Salt, Etha, Cold, Heat, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.731, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S358" CDS 1090401..1092728 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576783; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting protein" /protein_id="NP_388897.1" /db_xref="EnsemblGenomes-Gn:BSU10160" /db_xref="EnsemblGenomes-Tr:CAB12856" /db_xref="GOA:P32399" /db_xref="InterPro:IPR017500" /db_xref="InterPro:IPR017501" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR023908" /db_xref="SubtiList:BG10433" /db_xref="UniProtKB/Swiss-Prot:P32399" /translation="MNTIRSQWKDIVTSKKLLIPIIAILFVPLIYSGVFLKAYWDPYG TVDQLPVVVVNQDKGATYEGEKLQIGDDLVKELKDNNNFDWHFSNDLDQSLKDLLNQK YYLVVEIPEDFSKNASTVLDKNPKKLDLKYHTNAGSNYVGATIGEKAIDKLKASVSKE VTEQYTKVIFDNFKDIAKGLSDASSGAKKIDDGTKDAKNGSAQLKENLAKLKESTATI SDKTAQLADGAAQVTSGIQSLDSSLGKFQDSSNQIYDKSSQLAAGSGELTSKMNELLA GLQNVQKGTPNLTNGLDQLNSKVQEGSEKAAKAEKIINALDLTKLETAVNNLEKSETA MKEFKKQLTDFENSLKNRDQAFKNVINSSDFLTAEQKSQLINSVEKKLPQVDAPDFDQ ILSQLPTADQLPDIATIKSSLEDVKAQVAQVKAMPEATSKLYNGAKTIQDAIDRLTEG ADKIYNGSQKLTDGQTKLTAGIGEYNKQFAKAKAGSEQLVTGSSQVSGGLFKLLDGSK QVQSGSSKLADGSASLDTGLGKLLDGTGELSSKLKDAADQTGDIDADDQTYGMFADPV KTKDDAIHSVPNYGTGLTPYILSMGLYVGGIMLTVVFPLKEASGRPRNGFEWFFSKFN VMMLVGIIQSLIVATVLLLGIGLEVESTWRFYVFTIITSLAFLAIIQFLATTMGNPGR FIAVIILVLQLGASGGTFPLELLPNFYQVIHGALPMTYSINGFRAVISNGDFGYMWQM AGVLIGIALVMIALSITYFTMLSRKEETSEEQPAS*" gene 1090401..1092728 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" downshifts 1092710 /Source="Nicolas_upshifts" /id="D552" /incds=0 /nref=65 /ntot=211 /MaxReadThrough="0.57274" /MaxDrop="5.58483" /score="-4.79013797" /energy="-7.3" /TU="NA" /idTUdmin="U817" /TUdmin=0 /isTUend="TRUE" CDS complement(1092770..1093747) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 21383089, 21542858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 21383089, 21542858; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 2" /protein_id="NP_388898.1" /db_xref="EnsemblGenomes-Gn:BSU10170" /db_xref="EnsemblGenomes-Tr:CAB12857" /db_xref="GOA:O07600" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13048" /db_xref="UniProtKB/Swiss-Prot:O07600" /translation="MSKAKITAIGTYAPSRRLTNADLEKIVDTSDEWIVQRTGMRERR IADEHQFTSDLCIEAVKNLKSRYKGTLDDVDMILVATTTSDYAFPSTACRVQEYFGWE STGALDINATCAGLTYGLHLANGLITSGLHQKILVIAGETLSKVTDYTDRTTCVLFGD AAGALLVERDEETPGFLASVQGTSGNGGDILYRAGLRNEINGVQLVGSGKMVQNGREV YKWAARTVPGEFERLLHKAGLSSDDLDWFVPHSANLRMIESICEKTPFPIEKTLTSVE HYGNTSSVSIVLALDLAVKAGKLKKDQIVLLFGFGGGLTYTGLLIKWGM*" gene complement(1092770..1093747) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" downshifts complement(1092783) /Source="Nicolas_upshifts" /id="D553" /incds=0 /nref=21 /ntot=217 /MaxReadThrough="1.99012" /MaxDrop="7.90433" /score="-9.17544275" /energy="-7.3" /TU="NA" /idTUdmin="U819" /TUdmin="-19" /isTUend="TRUE" promotor_-10 complement(1093761..1093780) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1093779) /Source="Nicolas_upshifts" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" promotor_-35 complement(1093794..1093800) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1093806..1093814 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1093825..1093843 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1093832 /Source="Nicolas_upshifts" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" CDS 1093874..1094650 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388899.1" /db_xref="EnsemblGenomes-Gn:BSU10180" /db_xref="EnsemblGenomes-Tr:CAB12858" /db_xref="GOA:O07601" /db_xref="InterPro:IPR011397" /db_xref="SubtiList:BG13049" /db_xref="UniProtKB/Swiss-Prot:O07601" /translation="MVSQEAVVFLALSGAIAFLLPIGLIVWFKRKYGASLKVFFIGAL TFFVFAQLLEGGVHVYVLQVNEMTKEAMQHPLWYGIYGCLMAGIFEECGRYLMMRFFM KRHHTWADGLAFGAGHGGLEAILITGLSSISLIVYAFAINSGTFEQLLVNGDVKQALL PIQEQLLHTPSYEWMLGGIERISAIAVQIGLSLLVLYAVKNRRPLFLLYSILLHALFN VPAVLYQRGIIEHAAAVEIIVALIAALSVYWIVKAKRVFQ*" gene 1093874..1094650 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" S_feature complement(1094366..1094987) /Source="Nicolas_S_feature" /locus_tag="new_1094366_1094987_c" /HighExp="B36, BT, B60, Pyr, S8, G/S, G135, Mal, M/G, Glucon" /AntisenseName="yhfC" /AntisenseCor="-0.12937903461570099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="0.51248700000000003" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S359" S_feature 1094651..1095022 /Source="Nicolas_S_feature" /locus_tag="new_1094651_1095022" /HighExp="Lbstat, S2, M0t90, M40t90, HiOs, SMMPr, T-2.40H, Etha, Lbtran, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.48518699999999998" /TUshortSig="SigH" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S360" promotor_-10 complement(1094965..1094984) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1094986) /Source="Nicolas_upshifts" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" promotor_-35 complement(1094998..1095007) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1095000..1095007 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1095022..1095041 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1095024 /Source="Nicolas_upshifts" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" CDS 1095063..1096103 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15713475, 15743956; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminopeptidase" /protein_id="NP_388901.1" /db_xref="EnsemblGenomes-Gn:BSU10200" /db_xref="EnsemblGenomes-Tr:CAB12860" /db_xref="GOA:O07603" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13051" /db_xref="UniProtKB/Swiss-Prot:O07603" /translation="MTSVRKTMELIKELVSIPSPTGNTYEVINYIESLLKEWKVETVR NHKGGLIATLPGRDTSRHRMLTAHVDTLGAMVKEIKADGRLKIDLIGGFRYNSIEGEY CQIETASGKMYTGTILMHQTSVHVYKDAGKAERNQENMEIRLDEPVHCRKDTEELGIG VGDFVSFDPRVEITSSGFIKSRHLDDKASVALLLRLIHEIQTEDIELPYTTHFLISNN EEIGYGGNSNIPPETVEYLAVDMGAIGDGQATDEYSVSICVKDASGPYHYQLRKHLVQ LAEKHHIDYKLDIYPYYGSDASAAIKSGHDIVHGLIGPGIDASHAFERTHKSSLRHTA KLLYYYVQSPMV*" gene 1095063..1096103 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" CDS 1096116..1096523 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11157739, 14517985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding PUA-containing enzyme" /protein_id="NP_388902.1" /db_xref="EnsemblGenomes-Gn:BSU10210" /db_xref="EnsemblGenomes-Tr:CAB12861" /db_xref="InterPro:IPR007374" /db_xref="InterPro:IPR009326" /db_xref="InterPro:IPR015947" /db_xref="SubtiList:BG13052" /db_xref="UniProtKB/Swiss-Prot:O07604" /translation="MKIYKLKSTFGWEGDDGLGEQLIQQILAGEKSATCAPKSLYSKD ELRDVYQTAGQLVTVYDKHDNPRCNIKVTDVFETTFGAPDMRLVKGEGNGDRIEEFQE DHRMAWAELIKSGELELNEDTVLITELFVLVKD*" gene 1096116..1096523 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" downshifts 1096494 /Source="Nicolas_upshifts" /id="D554" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="0.87656" /MaxDrop="5.21108" /score="22.0862441" /energy="-20.3" /TU="U822" /idTUdmin="U822" /TUdmin="-23" /isTUend="FALSE" CDS complement(1096560..1097849) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/sodium-glutamate (aspartate) symport permease" /protein_id="NP_388903.1" /db_xref="EnsemblGenomes-Gn:BSU10220" /db_xref="EnsemblGenomes-Tr:CAB12862" /db_xref="GOA:O07605" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12595" /db_xref="UniProtKB/Swiss-Prot:O07605" /translation="MKRIKFGLATQIFVGLILGVIVGVIWYGNPALPTYLQPIGDLFL RLIKMIVIPIVVSSLIIGVAGAGNGKQVGKLGFRTILYFEIITTFAIILGLALANIFH PGTGVNIHEAQKSDISQYVETEKEQSNKSVAETFLHIVPTNFFQSLVEGDLLAIICFT VLFALGISAIGERGKPVLAFFEGVSHAMFHVVNLVMKVAPFGVFALIGVTVSKFGLGS LISLGKLVGLVYVALAFFLIVIFGIVAKIAGISIFKFLAYMKDEILLAFSTSSSETVL PRIMEKMEKIGCPKGIVSFVIPIGYTFNLDGSVLYQSIAALFLAQVYGIDLTIWHQIT LVLVLMVTSKGMAAVPGTSFVVLLATLGTIGVPAEGLAFIAGVDRIMDMARTVVNLTG NALAAVVMSKWEGMFNPAKAETVMSQSKTEQNATISG*" gene complement(1096560..1097849) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" downshifts complement(1096590) /Source="Nicolas_upshifts" /id="D555" /incds=0 /nref=226 /ntot=280 /MaxReadThrough="2.99263" /MaxDrop="7.79183" /score="48.7726082" /energy="-21.9" /TU="U823" /idTUdmin="U824" /TUdmin=3 /isTUend="TRUE" S_feature complement(1097850..1097950) /Source="Nicolas_S_feature" /locus_tag="new_1097850_1097950_c" /HighExp="C90, LoTm, LBGexp, Cold, UNK1, BC, dia5, Lbexp, S1, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S361" promotor_-10 complement(1097949..1097968) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1097950) /Source="Nicolas_upshifts" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" S_feature complement(1097952..1098088) /Source="Nicolas_S_feature" /locus_tag="new_1097952_1098088_c" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, T2.30H, T5.0H, Cold, T2.0H, S0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S362" promotor_-35 complement(1097983..1097989) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1098120..1098260) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388904.1" /db_xref="EnsemblGenomes-Gn:BSU10230" /db_xref="EnsemblGenomes-Tr:CAB12863" /db_xref="InterPro:IPR025432" /db_xref="SubtiList:BG13053" /db_xref="UniProtKB/Swiss-Prot:O07606" /translation="MVMLGKITEFFRNLPSKKCAECGKKIEEQHECYGNICNDCIKVN DL*" gene complement(1098120..1098260) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" downshifts complement(1098133) /Source="Nicolas_upshifts" /id="D556" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.70702" /MaxDrop="4.73949" /score="28.7665297" /energy="-13.6" /TU="U824" /idTUdmin="U824" /TUdmin="-1540" /isTUend="FALSE" promotor_-10 complement(1098279..1098298) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1098298) /Source="Nicolas_upshifts" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" promotor_-35 complement(1098311..1098318) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1098342..1098348 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1098362..1098381 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1098365 /Source="Nicolas_upshifts" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" CDS 1098412..1099146 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388905.1" /db_xref="EnsemblGenomes-Gn:BSU10240" /db_xref="EnsemblGenomes-Tr:CAB12864" /db_xref="GOA:O07607" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13054" /db_xref="UniProtKB/Swiss-Prot:O07607" /translation="MKVTVIGCYGGFPAANEATSGYLFQSGDYSLLVDCGSAVLSKLF GYVPAEKLDAVVLSHYHHDHIADIGPLQFAKQVGSFLGKGEHTLPIYGHDADIEQFQK LTYKTHTKGIAYQPDQPLTAGPFTITFLKTIHPVTCYAMRITDGSHTVVYTADSSYQD SFIPFSKDADLLISECNFYADQDGTSAGHMNSLEAGRIAKEAGAGELLLTHLPHFGVH DNLRKEAKTVFNGEVNIAKSGFVWEG*" gene 1098412..1099146 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" CDS 1099159..1100154 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" /EC_number="6.3.1.20" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoate-protein ligase" /protein_id="NP_388906.1" /db_xref="EnsemblGenomes-Gn:BSU10250" /db_xref="EnsemblGenomes-Tr:CAB12865" /db_xref="GOA:O07608" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004562" /db_xref="InterPro:IPR019491" /db_xref="SubtiList:BG13055" /db_xref="UniProtKB/Swiss-Prot:O07608" /translation="MLFIDNQNINDPRINLAIEEYCVKHLDPEQQYLLFYVNQPSIII GKNQNTIEEINTKYVEENGIIVVRRLSGGGAVYHDLGNLNFSFITKDDGDSFHNFKKF TEPVIQALHQLGVEAELSGRNDIVVDGRKISGNAQFATKGRIFSHGTLMFDSAIDHVV SALKVKKDKIESKGIKSIRSRVANISEFLDDKMTTEEFRSHLLRHIFNTNDVGNVPEY KLTEKDWETIHQISKERYQNWDWNYGRSPKFNLNHSKRYPVGSIDLHLEVKKGKIEDC KIFGDFFGVGDVSEIENLLVGKQYERSVIADVLEGVNLKHYFGNITKEDFLDLIY*" gene 1099159..1100154 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" CDS 1100219..1100863 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11790741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-binding epimerase / hydratase" /protein_id="NP_388907.1" /db_xref="EnsemblGenomes-Gn:BSU10260" /db_xref="EnsemblGenomes-Tr:CAB12866" /db_xref="GOA:O07609" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13056" /db_xref="UniProtKB/Swiss-Prot:O07609" /translation="MKVFLIGANGQIGQRLVSLFQDNPDHSIRAMVRKEEQKASLEAA GAEAVLANLEGSPEEIAAAAKGCDAIIFTAGSGGSTGYDKTLLVDLDGAAKAIEAAAI AGIKRFIMVSALQAHNRENWNEALKPYYVAKHYADKILEASGLTYTIIRPGGLRNEPG TGTVSAAKDLERGFISRDDVAKTVIASLDEKNTENRAFDLTEGDTPIAEALKKL*" gene 1100219..1100863 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" downshifts 1100851 /Source="Nicolas_upshifts" /id="D557" /incds=0 /nref=239 /ntot=258 /MaxReadThrough="0.56809" /MaxDrop="6.84076" /score="18.2092404" /energy="-10" /TU="NA" /idTUdmin="U825" /TUdmin=0 /isTUend="TRUE" promotor_-35 1100891..1100894 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1100909..1100928 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1100916 /Source="Nicolas_upshifts" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" CDS 1100980..1102521 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long-chain fatty-acid-CoA ligase (degradative)" /protein_id="NP_388908.2" /db_xref="EnsemblGenomes-Gn:BSU10270" /db_xref="EnsemblGenomes-Tr:CAB12867" /db_xref="GOA:O07610" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020459" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13057" /db_xref="UniProtKB/Swiss-Prot:O07610" /translation="MNLVSKLEETASEKPDSIACRFKDHMMTYQELNEYIQRFADGLQ EAGMEKGDHLALLLGNSPDFIIAFFGALKAGIVVVPINPLYTPTEIGYMLTNGDVKAI VGVSQLLPLYESMHESLPKVELVILCQTGEAEPEAADPEVRMKMTTFAKILRPTSAAK QNQEPVPDDTAVILYTSGTTGKPKGAMLTHQNLYSNANDVAGYLGMDERDNVVCALPM FHVFCLTVCMNAPLMSGATVLIEPQFSPASVFKLVKQQQATIFAGVPTMYNYLFQHEN GKKDDFSSIRLCISGGASMPVALLTAFEEKFGVTILEGYGLSEASPVTCFNPFDRGRK PGSIGTSILHVENKVVDPLGRELPAHQVGELIVKGPNVMKGYYKMPMETEHALKDGWL YTGDLARRDEDGYFYIVDRKKDMIIVGGYNVYPREVEEVLYSHPDVKEAVVIGVPDPQ SGEAVKGYVVPKRSGVTEEDIMQHCEKHLAKYKRPAAITFLDDIPKNATGKMLRRALR DILPQ*" gene 1100980..1102521 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" downshifts 1102501 /Source="Nicolas_upshifts" /id="D558" /incds=0 /nref=5 /ntot=108 /MaxReadThrough="2.74134" /MaxDrop="3.72638" /score="15.3712924" /energy="-10.4" /TU="NA" /idTUdmin="U826" /TUdmin=0 /isTUend="TRUE" CDS complement(1102560..1102955) /gene="yhfM" /locus_tag="BSU_10280" /old_locus_tag="BSU10280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388909.1" /db_xref="EnsemblGenomes-Gn:BSU10280" /db_xref="EnsemblGenomes-Tr:CAB12868" /db_xref="SubtiList:BG13058" /db_xref="UniProtKB/Swiss-Prot:O07611" /translation="MKKIVAAIVVIGLVFIAFFYLYSRSGDVYQSVDADLITLSSSGQ EDIEIEKRQHVKDMLDIMNQGKQVKTEKTSAPDYEGTIKFHKDRYDSFRLWIDGSQQA VFLKDGTYYKLSKNDTKALLNIIKKEAKD*" gene complement(1102560..1102955) /gene="yhfM" /locus_tag="BSU_10280" /old_locus_tag="BSU10280" downshifts complement(1102577) /Source="Nicolas_upshifts" /id="D559" /incds=0 /nref=46 /ntot=89 /MaxReadThrough="0.75539" /MaxDrop="6.88759" /score="17.4775611" /energy="-10.4" /TU="NA" /idTUdmin="U827" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1102975..1102986) /Source="Nicolas_upshift_promotors" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1102979) /Source="Nicolas_upshifts" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" promotor_-35 complement(1103001..1103007) /Source="Nicolas_upshift_promotors" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1103040..1103043 /Source="Nicolas_upshift_promotors" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1103051 /Source="Nicolas_upshifts" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" promotor_-10 1103058..1103077 /Source="Nicolas_upshift_promotors" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1103104..1104384 /gene="yhfN" /locus_tag="BSU_10290" /old_locus_tag="BSU10290" /EC_number="3.4.24.84" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9015299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane metalloprotease" /protein_id="NP_388910.1" /db_xref="EnsemblGenomes-Gn:BSU10290" /db_xref="EnsemblGenomes-Tr:CAB12869" /db_xref="GOA:P40769" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR027057" /db_xref="InterPro:IPR032456" /db_xref="SubtiList:BG11029" /db_xref="UniProtKB/Swiss-Prot:P40769" /translation="MRKWIAAAGLAYVLYGLFFYWYFFLSGDSAIPEAVKGTQADPAS FMKPSELAVAEQYSNVKNFLFFIGVPLDWFLFFVLLVSGVSKKIKKWIEAAVPFRFLQ TVGFVFVLSLITTLVTLPLDWIGYQVSLDYNISTQTTASWAKDQVISFWISFPIFTLC VLVFYWLIKRHEKKWWLYAWLLTVPFSLFLFFIQPVIIDPLYNDFYPLKNKELESKIL ELADEANIPADHVYEVNMSEKTNALNAYVTGIGANKRIVLWDTTLNKLDDSEILFIMG HEMGHYVMKHVYIGLAGYLLVSLAGFYVIDKLYKRTVRLTRSMFHLEGRHDLAALPLL LLLFSVLSFAVTPFSNAVSRYQENKADQYGIELTENREAAVKTFQDLAVTGLSQVDPP VLVKIFRGSHPSIMERIQHAEKEENAPEHQDADK*" gene 1103104..1104384 /gene="yhfN" /locus_tag="BSU_10290" /old_locus_tag="BSU10290" promotor_-10 complement(1103531..1103550) /Source="Nicolas_upshift_promotors" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1103545) /Source="Nicolas_upshifts" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1103566..1103571) /Source="Nicolas_upshift_promotors" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1104371 /Source="Nicolas_upshifts" /id="D560" /incds=0 /nref=2 /ntot=57 /MaxReadThrough="3.82026" /MaxDrop="3.6342" /score="6.45541384" /energy="-12.7" /TU="U828" /idTUdmin="U828" /TUdmin="-132" /isTUend="FALSE" downshifts complement(1104421) /Source="Nicolas_upshifts" /id="D561" /incds=0 /nref=129 /ntot=219 /MaxReadThrough="-0.11848" /MaxDrop="9.02627" /score="-6.76069514" /energy="-7.8" /TU="NA" /idTUdmin="U830" /TUdmin=4 /isTUend="TRUE" CDS complement(1104423..1105568) /gene="aprE" /locus_tag="BSU_10300" /old_locus_tag="BSU10300" /EC_number="3.4.21.62" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine alkaline protease (Ca(2+)-dependent subtilisin E)" /protein_id="NP_388911.2" /db_xref="EnsemblGenomes-Gn:BSU10300" /db_xref="EnsemblGenomes-Tr:CAB12870" /db_xref="GOA:P04189" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR009020" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="PDB:1SCJ" /db_xref="PDB:3WHI" /db_xref="SubtiList:BG10190" /db_xref="UniProtKB/Swiss-Prot:P04189" /translation="MRSKKLWISLLFALTLIFTMAFSNMSAQAAGKSSTEKKYIVGFK QTMSAMSSAKKKDVISEKGGKVQKQFKYVNAAAATLDEKAVKELKKDPSVAYVEEDHI AHEYAQSVPYGISQIKAPALHSQGYTGSNVKVAVIDSGIDSSHPDLNVRGGASFVPSE TNPYQDGSSHGTHVAGTIAALNNSIGVLGVAPSASLYAVKVLDSTGSGQYSWIINGIE WAISNNMDVINMSLGGPTGSTALKTVVDKAVSSGIVVAAAAGNEGSSGSTSTVGYPAK YPSTIAVGAVNSSNQRASFSSAGSELDVMAPGVSIQSTLPGGTYGAYNGTSMATPHVA GAAALILSKHPTWTNAQVRDRLESTATYLGNSFYYGKGLINVQAAAQ*" gene complement(1104423..1105568) /gene="aprE" /locus_tag="BSU_10300" /old_locus_tag="BSU10300" S_feature complement(1105569..1105635) /Source="Nicolas_S_feature" /locus_tag="new_1105569_1105635_c" /HighExp="BC, T5.0H, LoTm, Sw, T4.0H, T3.30H, S1, T3.0H, S2, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S363" promotor_-10 complement(1105624..1105643) /Source="Nicolas_upshift_promotors" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1105641) /Source="Nicolas_upshifts" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" promotor_-35 complement(1105659..1105663) /Source="Nicolas_upshift_promotors" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1105948..1105955 /Source="Nicolas_upshift_promotors" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="promotor_-35" promotor_-10 1105970..1105989 /Source="Nicolas_upshift_promotors" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="promotor_-10" upshifts 1105972 /Source="Nicolas_upshifts" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" CDS 1106003..1106452 /gene="yhfO" /locus_tag="BSU_10310" /old_locus_tag="BSU10310" /EC_number="2.3.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388912.1" /db_xref="EnsemblGenomes-Gn:BSU10310" /db_xref="EnsemblGenomes-Tr:CAB12871" /db_xref="GOA:O07614" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13059" /db_xref="UniProtKB/Swiss-Prot:O07614" /translation="MNIRQAKTSDAAAIAPLFNQYREFYRQASDLQGAEAFLKARLEN HESVILIAEENGEFIGFTQLYPTFSSVSMKRIYILNDLFVVPHARTKGAGGRLLSAAK DYAGQNGAKCLTLQTEHHNRKARSLYEQNGYEEDTGFVHYCLNVPAK*" gene 1106003..1106452 /gene="yhfO" /locus_tag="BSU_10310" /old_locus_tag="BSU10310" promotor_-35 1106468..1106475 /Source="Nicolas_upshift_promotors" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1106490..1106509 /Source="Nicolas_upshift_promotors" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1106497 /Source="Nicolas_upshifts" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" CDS 1106524..1107516 /gene="yhfP" /locus_tag="BSU_10320" /old_locus_tag="BSU10320" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9643546, 12057962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388913.1" /db_xref="EnsemblGenomes-Gn:BSU10320" /db_xref="EnsemblGenomes-Tr:CAB12872" /db_xref="GOA:O07615" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR014188" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="PDB:1TT7" /db_xref="PDB:1Y9E" /db_xref="SubtiList:BG13060" /db_xref="UniProtKB/Swiss-Prot:O07615" /translation="MSTLFQALQAEKNADDVSVHVKTISTEDLPKDGVLIKVAYSGIN YKDGLAGKAGGNIVREYPLILGIDAAGTVVSSNDPRFAEGDEVIATSYELGVSRDGGL SEYASVPGDWLVPLPQNLSLKEAMVYGTAGFTAALSVHRLEQNGLSPEKGSVLVTGAT GGVGGIAVSMLNKRGYDVVASTGNREAADYLKQLGASEVISREDVYDGTLKALSKQQW QGAVDPVGGKQLASLLSKIQYGGSVAVSGLTGGGEVPATVYPFILRGVSLLGIDSVYC PMDVRAAVWERMSSDLKPDQLLTIVDREVSLEETPGALKDILQNRIQGRVIVKL*" gene 1106524..1107516 /gene="yhfP" /locus_tag="BSU_10320" /old_locus_tag="BSU10320" downshifts 1107517 /Source="Nicolas_upshifts" /id="D562" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="4.4421" /MaxDrop="2.9095" /score="14.183693" /energy="-15.3" /TU="U831,U832" /idTUdmin="U831" /TUdmin="-154" /isTUend="FALSE" S_feature 1107562..1107672 /Source="Nicolas_S_feature" /locus_tag="new_1107562_1107672" /HighExp="Etha, dia15, LoTm, Salt, H2O2, LBGexp, Diami, Paraq, dia5, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S364" promotor_-35 1107650..1107657 /Source="Nicolas_upshift_promotors" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1107673..1107692 /Source="Nicolas_upshift_promotors" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1107674 /Source="Nicolas_upshifts" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" CDS 1107733..1108704 /gene="yhfQ" /locus_tag="BSU_10330" /old_locus_tag="BSU10330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16672620, 20147287; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III) siderophore-binding lipoprotein" /protein_id="NP_388914.2" /db_xref="EnsemblGenomes-Gn:BSU10330" /db_xref="EnsemblGenomes-Tr:CAB12873" /db_xref="GOA:C0SP94" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG13061" /db_xref="UniProtKB/Swiss-Prot:C0SP94" /translation="MKKTLIILTVLLLSVLTAACSSSSGNQNSKEHKVAVTHDLGKTN VPEHPKRVVVLELGFIDTLLDLGITPVGVADDNKAKQLINKDVLKKIDGYTSVGTRSQ PSMEKIASLKPDLIIADTTRHKKVYDQLKKIAPTIALNNLNADYQDTIDASLTIAKAV GKEKEMEKKLTAHEEKLSETKQKISANSQSVLLIGNTNDTIMARDENFFTSRLLTQVG YRYAISTSGNSDSSNGGDSVNMKMTLEQLLKTDPDVIILMTGKTDDLDADGKRPIEKN VLWKKLKAVKNGHVYHVDRAVWSLRRSVDGANAILDELQKEMPAAKK*" gene 1107733..1108704 /gene="yhfQ" /locus_tag="BSU_10330" /old_locus_tag="BSU10330" downshifts 1108683 /Source="Nicolas_upshifts" /id="D563" /incds=0 /nref=172 /ntot=251 /MaxReadThrough="2.22013" /MaxDrop="5.6726" /score="27.9181244" /energy="-10.9" /TU="NA" /idTUdmin="U833" /TUdmin=0 /isTUend="TRUE" CDS complement(1108736..1109317) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10869096, 11827481, 12870714, 17693564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869096, 11827481, 12870714, 17693564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase; putative (phosphoglycerate) mutase" /protein_id="NP_388915.1" /db_xref="EnsemblGenomes-Gn:BSU10340" /db_xref="EnsemblGenomes-Tr:CAB12874" /db_xref="GOA:O07617" /db_xref="InterPro:IPR001345" /db_xref="InterPro:IPR013078" /db_xref="InterPro:IPR029033" /db_xref="SubtiList:BG13062" /db_xref="UniProtKB/Swiss-Prot:O07617" /translation="MTAVCLVRHGETDWNLQQKCQGKTDIPLNATGERQARETGEYVK DFSWDIIVTSPLKRAKRTAEIINEYLHLPIVEMDDFKERDYGDAEGMPLEERTKRYPD NIYPNMETLEELTDRLMGGLAKVNQAYPNKKVLIVAHGAAIHALLTEISGGDPELQST RLVNACLSNIEFAEEKWRIKDYNINSHLSGFIK*" gene complement(1108736..1109317) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" downshifts complement(1108759) /Source="Nicolas_upshifts" /id="D564" /incds=0 /nref=218 /ntot=256 /MaxReadThrough="1.23197" /MaxDrop="6.359" /score="28.9228703" /energy="-10.9" /TU="NA" /idTUdmin="U834" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1109341..1109360) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1109353) /Source="Nicolas_upshifts" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" promotor_-35 complement(1109376..1109379) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1109388..1110482) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" /EC_number="2.3.1.9" /experiment="publication(s) with functional evidences, PMID:12368242, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acetyltransferase" /protein_id="NP_388916.1" /db_xref="EnsemblGenomes-Gn:BSU10350" /db_xref="EnsemblGenomes-Tr:CAB12875" /db_xref="GOA:O07618" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG13063" /db_xref="UniProtKB/Swiss-Prot:O07618" /translation="MNAVIVDAKRTIFGNQNGLLKPFLPEDLAAPIIRCLSRKLEDQV DEVILGNATGRGGNLARLSALQAGLPLSVPGMTIDRQCGSGLEAVRYACSLIQAGAGT MYIAGGSESSSQSPFSERARFSPDAIGDPDMGIAAEYTAARYSISRSMQDEYALLSHQ RSRNAHDEGFYREEVVALGELETDEAFLKTRPIEAIIPRAKPVFDTSSGTVTAANSSG IADGAAALLVMEEEKAAALGLKPVLRFIGSAVSGIHPNFPPAAPVVAIRQLLHTHDVT PDDIDLFEINEAFAVKICVCSQELGIPFSKINVRGGALALGHPYGASGAALVTRLFYE AKRRPDCQYAVAAIGSGGGIGLALLFEVLA*" gene complement(1109388..1110482) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" CDS complement(1110479..1111918) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12368242, 28032445, 28414710; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative long-chain fatty-acid-CoA ligase (proofreading for biotin synthesis)" /protein_id="NP_388917.1" /db_xref="EnsemblGenomes-Gn:BSU10360" /db_xref="EnsemblGenomes-Tr:CAB12876" /db_xref="GOA:O07619" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13064" /db_xref="UniProtKB/Swiss-Prot:O07619" /translation="MTITHTYSSTAETSPGRVAIQTESEQITYHDWDRLVSQTANWLR SQPSMPNRVAILLPNSLAFLQLFAGAAAAGCTAIPIDTRWSPAECKERLSISNADLVV TLAFFKNKLTDSQTPVVLLDNCMADISEAAADPLPTIDPEHPFYMGFTSGSTGKPKAF TRSHRSWMESFTCTETDFSISSDDKVLIPGALMSSHFLYGAVSTLFLGGTVCLLKKFS PAKAKEWLCRESISVLYTVPTMTDALARIEGFPDSPVKIISSGADWPAESKKKLAAAW PHLKLYDFYGTSELSFVTFSSPEDSKRKPHSAGRPFHNVRIEIRNAGGERCQPGEIGK IFVKSPMRFSGYVNGSTPDEWMTVDDMGYVDEEGFLYISGRENGMIVYGGLNIFPEEI ERVLLACPEVESAAVVGIPDEYWGEIAVAVILGNANARTLKAWCKQKLASYKIPKKWV FADSLPETSSGKIARSRVKKWLEESVQYK*" gene complement(1110479..1111918) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" CDS complement(1111925..1112485) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12368242, 15849754, 16850406, 18931129, 23709504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="biotin transporter" /protein_id="NP_388918.1" /db_xref="EnsemblGenomes-Gn:BSU10370" /db_xref="EnsemblGenomes-Tr:CAB12877" /db_xref="GOA:O07620" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13065" /db_xref="UniProtKB/Swiss-Prot:O07620" /translation="MLKLIDMMHIAIFTALMAVLGFMPPLFLSFTPVPITLQTLGVML AGSILRPKSAFLSQLVFLLLVAFGAPLLPGGRGGFGVFFGPSAGFLIAYPLASWLISL AANRLRKVTVLRLFFTHIVFGIIFIYLLGIPVQAFIMHIDLSQAAFMSLAYVPGDLIK AAVSAFLAIKITQALSLSDTMFTKGG*" gene complement(1111925..1112485) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" misc_feature complement(1111935..1111954) /Source="Nicolas_upshift_promotors" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1111949) /Source="Nicolas_upshifts" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" promotor_-10 complement(1112510..1112529) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1112524) /Source="Nicolas_upshifts" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" promotor_-35 complement(1112544..1112551) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1112620..1113918) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="heme-based dioxygen sensor" /protein_id="NP_388919.1" /db_xref="EnsemblGenomes-Gn:BSU10380" /db_xref="EnsemblGenomes-Tr:CAB12878" /db_xref="GOA:O07621" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR009050" /db_xref="PDB:1OR4" /db_xref="PDB:1OR6" /db_xref="SubtiList:BG13066" /db_xref="UniProtKB/Swiss-Prot:O07621" /translation="MLFKKDRKQETAYFSDSNGQQKNRIQLTNKHADVKKQLKMVRLG DAELYVLEQLQPLIQENIVNIVDAFYKNLDHESSLMDIINDHSSVDRLKQTLKRHIQE MFAGVIDDEFIEKRNRIASIHLRIGLLPKWYMGAFQELLLSMIDIYEASITNQQELLK AIKATTKILNLEQQLVLEAFQSEYNQTRDEQEEKKNLLHQKIQETSGSIANLFSETSR SVQELVDKSEGISQASKAGTVTSSTVEEKSIGGKKELEVQQKQMNKIDTSLVQIEKEM VKLDEIAQQIEKIFGIVTGIAEQTNLLSLNASIESARAGEHGKGFAVVANEVRKLSED TKKTVSTVSELVNNTNTQINIVSKHIKDVNELVSESKEKMTQINRLFDEIVHSMKISK EQSGKIDVDLQAFLGGLQEVSRAVSHVAASVDSLVILTEE*" gene complement(1112620..1113918) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" downshifts complement(1112631) /Source="Nicolas_upshifts" /id="D565" /incds=0 /nref=209 /ntot=243 /MaxReadThrough="2.70691" /MaxDrop="6.97357" /score="5.86442746" /energy="-6.9" /TU="NA" /idTUdmin="U837" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1113972..1113990) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1113975) /Source="Nicolas_upshifts" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" promotor_-35 complement(1114004..1114010) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1114057..1115586) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with Rieske [2Fe-2S] center" /protein_id="NP_388920.1" /db_xref="EnsemblGenomes-Gn:BSU10390" /db_xref="EnsemblGenomes-Tr:CAB12879" /db_xref="GOA:O07622" /db_xref="InterPro:IPR005805" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG13067" /db_xref="UniProtKB/Swiss-Prot:O07622" /translation="MANQHFAKEAPETYWKTSTDLPSFPALQEDTECDVTIIGGGITG ITTAYELTKRGFRVVLIEANQVLNGTTAHTTAKVTAQHDMIYDEFIRHFGLNHARLYY EANQNAIDYIKGIVDEHQIDCEWIEQDAYLYTANENAVQKIHTEHEAYTKLGIERDLI KDLPIPLGSKLALVMKNQAQFHPLQYLKALLEQIVQKGGRIYEETVALDIKKGERPEV VTKSRHAIKSRFIICCSHFPFYDGGGLYAARMYSDRSYVLAIKPKIEYPEGMYLSIDQ PSVALRYTVVNGEKLILFSGVSHKTGQGKAMSTHYETLRQLAESTIGIESIPYYWSTQ DLVTIDKIPFIGPMSENEDNILVATGFKKWGMTSSAVAATLLSDLVEKKENPYESIFT PSRFHLNPGLQKVISYNADVAKHLIKGKLEKPDVQFEDISPGEGKAVTINGRRAGAFR DETGCLHLVDTTCTHLGCEVEWNDSEHTWDCPCHGSRFKPSGEVVEGPAIKPLKQIDL D*" gene complement(1114057..1115586) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" promotor_-10 complement(1115613..1115631) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1115623) /Source="Nicolas_upshifts" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" promotor_-35 1115642..1115647 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1115646..1115651) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1115659 /Source="Nicolas_upshifts" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" promotor_-10 1115663..1115681 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1115698..1116555 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18643936, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388921.1" /db_xref="EnsemblGenomes-Gn:BSU10400" /db_xref="EnsemblGenomes-Tr:CAB12880" /db_xref="GOA:P40397" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11058" /db_xref="UniProtKB/Swiss-Prot:P40397" /translation="MANQKKKTLPPQHQNQQPGFEYLMDPRPVFDKPKKAKKLEGKTA IITGGDSGIGRAVSVLFAKEGANVVIVYLNEHQDAEETKQYVEKEGVKCLLIAGDVGD EAFCNDVVGQASQVFPSIDILVNNAAEQHVQPSIEKITSHQLIRTFQTNIFSMFYLTK AVLPHLKKGSSIINTASITAYKGNKTLIDYSATKGAIVTFTRSLSQSLVQQGIRVNAV APGPIWTPLIPASFAAKDVEVFGSDVPMERPGQPVEVAPSYLYLASDDSTYVTGQTIH VNGGTIVNG*" gene 1115698..1116555 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" downshifts 1116537 /Source="Nicolas_upshifts" /id="D566" /incds=0 /nref=10 /ntot=36 /MaxReadThrough="2.65833" /MaxDrop="4.80135" /score="-8.69335909" /energy="-4.5" /TU="NA" /idTUdmin="U839" /TUdmin=0 /isTUend="TRUE" CDS complement(1116583..1116816) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388922.1" /db_xref="EnsemblGenomes-Gn:BSU10410" /db_xref="EnsemblGenomes-Tr:CAB12881" /db_xref="InterPro:IPR014957" /db_xref="SubtiList:BG13087" /db_xref="UniProtKB/Swiss-Prot:O31594" /translation="MKEKKSYTELMKSRNTQKTKEFDVTMTDIYIQMVLDESLYNRRL AMLTDQINKALDEKDKDAFLTLSKEYAALKQSE*" gene complement(1116583..1116816) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" downshifts complement(1116616) /Source="Nicolas_upshifts" /id="D567" /incds=0 /nref=191 /ntot=247 /MaxReadThrough="3.34616" /MaxDrop="7.00218" /score="21.4902337" /energy="-12.3" /TU="U841" /idTUdmin="U844" /TUdmin="-3" /isTUend="TRUE" promotor_-10 complement(1116833..1116852) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1116836..1116837 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1116836 /Source="Nicolas_upshifts" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" promotor_-10 1116840..1116855 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1116855) /Source="Nicolas_upshifts" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" S_feature complement(1116857..1117712) /Source="Nicolas_S_feature" /locus_tag="new_1116857_1117712_c" /HighExp="Salt, Etha, C30, Heat, S8, LPhT, Gly, C90, S7, UNK1" /AntisenseName="comK" /AntisenseCor="-5.68778941053006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S365" promotor_-35 complement(1116867..1116874) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1117039..1117046 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-35" promotor_-10 1117058..1117077 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-10" upshifts 1117064 /Source="Nicolas_upshifts" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" CDS 1117109..1117687 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence transcription factor (CTF)" /protein_id="NP_388923.1" /db_xref="EnsemblGenomes-Gn:BSU10420" /db_xref="EnsemblGenomes-Tr:CAB12882" /db_xref="GOA:P40396" /db_xref="InterPro:IPR010461" /db_xref="SubtiList:BG11059" /db_xref="UniProtKB/Swiss-Prot:P40396" /translation="MSQKTDAPLESYEVNGATIAVLPEEIDGKICSKIIEKDCVFYVN MKPLQIVDRSCRFFGSSYAGRKAGTYEVTKISHKPPIMVDPSNQIFLFPTLSSTRPQC GWISHVHVKEFKATEFDDTEVTFSNGKTMELPISYNSFENQVYRTAWLRTKFQDRIDH RVPKRQEFMLYPKEERTKMIYDFILRELGERY*" gene 1117109..1117687 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" S_feature 1117688..1117833 /Source="Nicolas_S_feature" /locus_tag="new_1117688_1117833" /HighExp="GM 150, C30, T-4.40H, T-3.40H, GM 120, M9-tran, T-2.40H, C90, G/S, T-1.10H" /AntisenseName="yhxD" /AntisenseCor="-0.229484184862048" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S366" CDS complement(1117734..1118633) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388924.1" /db_xref="EnsemblGenomes-Gn:BSU10430" /db_xref="EnsemblGenomes-Tr:CAB12883" /db_xref="GOA:P40398" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11060" /db_xref="UniProtKB/Swiss-Prot:P40398" /translation="MSDSNLTNPIKAFFHDEFPEQYQEPPGLQKNMKPVPDCGEKSYK GSGKLTGRKALVTGGDSGIGRAAAIAYAREGADVAINYLPEEQPDAEEVKELIEAEGR KAVLIPGDLSDESFCQDLVKQSHHELGGLDVLALVAGKQQAVENIEDLPTEQIYKTFE VNVFSLYWVVKAALPYLPEGASIITTTSVEGYNPSPMLLDYAATKNAIIGFTVGLGKQ LASKGIRVNSVAPGPIWTPLQISGGQPTENIPKFGQGTPPAPLNRAGQPVELADVYVF LASENSSYVTSQVYGITGGIPTA*" gene complement(1117734..1118633) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" downshifts complement(1117757) /Source="Nicolas_upshifts" /id="D568" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="4.95535" /MaxDrop="4.1467" /score="-2.68458203" /energy="-14.6" /TU="U844" /idTUdmin="U844" /TUdmin="-1144" /isTUend="FALSE" promotor_-35 1117820..1117823 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1117835 /Source="Nicolas_upshifts" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 1117841..1117845 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1117879 /Source="Nicolas_upshifts" /id="D569" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="5.45904" /MaxDrop="5.6543" /score="-8.69335909" /energy="-4.5" /TU="U842" /idTUdmin="U843" /TUdmin=0 /isTUend="TRUE" S_feature 1117924..1118790 /Source="Nicolas_S_feature" /locus_tag="new_1117924_1118790" /HighExp="GM 150, C30, T-4.40H, C90, T-3.40H, T-2.40H, G/S, T-5.40H, M9-tran, nit" /AntisenseName="yhxD" /AntisenseCor="-0.32746434250834699" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S367" promotor_-10 complement(1118660..1118678) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1118677) /Source="Nicolas_upshifts" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" promotor_-35 complement(1118693..1118699) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1118767..1118774 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1118789..1118808 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1118792 /Source="Nicolas_upshifts" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" CDS 1118850..1119119 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388925.1" /db_xref="EnsemblGenomes-Gn:BSU10440" /db_xref="EnsemblGenomes-Tr:CAB12884" /db_xref="InterPro:IPR008613" /db_xref="SubtiList:BG13068" /db_xref="UniProtKB/Swiss-Prot:O07555" /translation="MKKAAAVLLSLGLVFGFSYGAGHVAEAKTKVKVYKNCKELNKVY KGGVARTSKVKNKGGKTKYKPYVSKALYDANKNKDRDKDLIACER*" gene 1118850..1119119 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" downshifts 1119111 /Source="Nicolas_upshifts" /id="D570" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.67325" /MaxDrop="7.59695" /score="27.4895724" /energy="-11.2" /TU="NA" /idTUdmin="U845" /TUdmin=0 /isTUend="TRUE" downshifts complement(1119159) /Source="Nicolas_upshifts" /id="D571" /incds=0 /nref=11 /ntot=113 /MaxReadThrough="2.40747" /MaxDrop="4.60953" /score="20.2036192" /energy="-11.2" /TU="NA" /idTUdmin="U846" /TUdmin=6 /isTUend="TRUE" CDS complement(1119162..1120631) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite cotransporter" /protein_id="NP_388926.1" /db_xref="EnsemblGenomes-Gn:BSU10450" /db_xref="EnsemblGenomes-Tr:CAB12885" /db_xref="GOA:O07556" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13069" /db_xref="UniProtKB/Swiss-Prot:O07556" /translation="MNAALIIIFGVLLLSIFLGIRAQKGKDMNLEQWTVGGRGFGTVF VFLLMAGEIYTTFTFLGGSGWAYGKGGPAFYIIAYGCLAYILSYWLLPAVWTYAKQHK LMSQSDFFTKKYNSPLLGILVSLVGIAALIPYLVLQLKGLGLIVSETSYGKITPTAAI WIGAVSITVYVMVSGIHGSAWISVVKDIMILVVVLFLGVYLPIHYYGGFQDMFQQIET AKPGFLTLPESGQSVAWFSSTVLLTALGFYMWPHTFSASYSAENPKVFRKNAIIMPLY QLVLLFVLFVGFAAILQVPDLNGADGDLSLLRLSLQAFDPWFVGIIGAAGLLTALVPG SMILMSASTLFAKNVYKVIAPRTTEQQVSALAKFLVPVIALISVYFTFKGGNTIVTLL LMGYSLVTQLFPALLFSLLKHNMVTKQGAFAGIIAGVGAVTYITMTETTIGTLFPALP QAAKDLNVGIVALLLNITVMMAVSLMTRKAKSAAADQAA*" gene complement(1119162..1120631) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" CDS complement(1120628..1120828) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388927.1" /db_xref="EnsemblGenomes-Gn:BSU10460" /db_xref="EnsemblGenomes-Tr:CAB12886" /db_xref="GOA:O07557" /db_xref="InterPro:IPR021741" /db_xref="SubtiList:BG13070" /db_xref="UniProtKB/Swiss-Prot:O07557" /translation="MKLIHVLAALPFIGILLGIPFANKVTPYVFGMPFILAYIVMWAL LTSALMAIVYVLDKENKKEEAE*" gene complement(1120628..1120828) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" S_feature complement(1120829..1120947) /Source="Nicolas_S_feature" /locus_tag="new_1120829_1120947_c" /HighExp="S1, Etha, HiOs, MG 120, LoTm, T-5.40H, S2, GM-0.1, GM-0.2, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S368" promotor_-10 complement(1120930..1120949) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1120947) /Source="Nicolas_upshifts" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" promotor_-35 complement(1120962..1120969) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1121035) /Source="Nicolas_upshifts" /id="D572" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.99656" /MaxDrop="2.67326" /score="20.2036192" /energy="-11.2" /TU="U848" /idTUdmin="U848" /TUdmin="-374" /isTUend="FALSE" CDS complement(1121036..1121398) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388928.1" /db_xref="EnsemblGenomes-Gn:BSU10470" /db_xref="EnsemblGenomes-Tr:CAB12887" /db_xref="GOA:O07558" /db_xref="SubtiList:BG13071" /db_xref="UniProtKB/Swiss-Prot:O07558" /translation="MPNLQEEIYDLIERALFLPMAITIFNRDLAGIEESTLKLKHPYK QLISESLKIAQKDLMEVRKELRKRKIAIRETERDEAFTLYTFVIDGYEENHRYFNPRI REQVSELLTYYLFAPDRL*" gene complement(1121036..1121398) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" promotor_-35 1121236..1121241 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1121257..1121275 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1121258 /Source="Nicolas_upshifts" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" S_feature 1121267..1121506 /Source="Nicolas_S_feature" /locus_tag="new_1121267_1121506" /HighExp="S6, S4, S8, S5, LoTm, B36, S3, S7, BT, B60" /AntisenseName="yhjD" /AntisenseCor="0.24202608585419999" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S369" promotor_-10 complement(1121428..1121447) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1121446) /Source="Nicolas_upshifts" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" promotor_-35 complement(1121462..1121469) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1121488..1121495 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1121508 /Source="Nicolas_upshifts" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" promotor_-10 1121509..1121528 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1121550..1122173 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388929.1" /db_xref="EnsemblGenomes-Gn:BSU10480" /db_xref="EnsemblGenomes-Tr:CAB12888" /db_xref="GOA:O07559" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13072" /db_xref="UniProtKB/Swiss-Prot:O07559" /translation="MLEHFLSYLTQEHLTELFQSYRAFGPLIAVLLPLIEAFLPFLPL IVFVVANTNSFGLWEGFILSWAGSTAGSILVFLIVRQYGQRKLLGFIRSHPSVRKLML WVERHGFGPMFLLLCFPFTPSAAVNVVAGLSRIGTRPFILAAASGKLVMIFMISFIGY DLHALITQPIRTVIAVLVITVLWYVGKKVERYLHVRASQREHDGGRQ*" gene 1121550..1122173 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" CDS 1122175..1122681 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" /EC_number="3.4.21.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9325333, 9694797, 11309398, 12897006, 14568161, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 9694797, 11309398, 12897006, 14568161, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388930.1" /db_xref="EnsemblGenomes-Gn:BSU10490" /db_xref="EnsemblGenomes-Tr:CAB12889" /db_xref="GOA:O07560" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG12674" /db_xref="UniProtKB/Swiss-Prot:O07560" /translation="MKKRFWFLAGVVSVVLAIQVKNAVFIDYKVEGVSMNPTFQEGNE LLVNKFSHRFKTIHRFDIVLFKGPDHKVLIKRVIGLPGETIKYKDDQLYVNGKQVAEP FLKHLKSVSAGSHVTGDFSLKDVTGTSKVPKGKYFVVGDNRIYSFDSRHFGPIREKNI VGVISDAE*" gene 1122175..1122681 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" downshifts 1122674 /Source="Nicolas_upshifts" /id="D573" /incds=0 /nref=131 /ntot=250 /MaxReadThrough="0.63331" /MaxDrop="4.58282" /score="-7.37718733" /energy="-7.1" /TU="NA" /idTUdmin="U847" /TUdmin=0 /isTUend="TRUE" promotor_-35 1122732..1122739 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1122753..1122772 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1122762..1122861 /Source="Nicolas_S_feature" /locus_tag="new_1122762_1122861" /HighExp="LBGstat, LBGexp, Lbtran, C90, dia0, Lbexp, HPh, dia5, aero, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S370" upshifts 1122762 /Source="Nicolas_upshifts" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" CDS 1122862..1124361 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" /EC_number="1.14.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7678243, 15121720; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic compound monooxygenase/hydroxylase" /protein_id="NP_388931.1" /db_xref="EnsemblGenomes-Gn:BSU10500" /db_xref="EnsemblGenomes-Tr:CAB12890" /db_xref="GOA:O07561" /db_xref="InterPro:IPR002938" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13073" /db_xref="UniProtKB/Swiss-Prot:O07561" /translation="MMMKYEAVIIGGGPVGFMLASELAIAGVGTCVIERLEKPVPHSK ALTLHPRTLELLEMRGILERFVSKGSKIPTGHFSMLDTRLDFSGLDTSCPYTLLLPQS KTEKLLEDHARSLGTEVFRGAEALAVTQNGEAVQTIFKDRDGSVRTITSKFAVGADGA GSTVRKQAKIEFPGTDSTVTAALGDVVLLSPPPSGVLSLCTKEGGVMIVPLSPDRYRV VVISPYRTQTPKDVPVTEEELKADLLRICGTDFGLTDPSWMSRFGNAARQAKRYRDGR IFLAGDAAHIHFPAGGQGLNVGLQDAMNLGWKLAAAIKGSAPSWLLDSYHDERHPAAE GLLRNTEAQTKLIDFTQAGLHLRSMMSELLAFPDVNRYVAGQISALDVRYEADRTMPP NRLNGARLPDMKLILSDGNSERLYSFLQNGTFVLLSLRQEADDHIEVKGLRTVTASLA EPNEKLRNVHTILIRPDGHVAWAVDASAPDCSEVIQKGISRWFSVTSRV*" gene 1122862..1124361 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" promotor_-35 1124369..1124376 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1124388 /Source="Nicolas_upshifts" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" promotor_-10 1124390..1124409 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1124438..1124965 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388932.1" /db_xref="EnsemblGenomes-Gn:BSU10510" /db_xref="EnsemblGenomes-Tr:CAB12891" /db_xref="GOA:Q796S4" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13074" /db_xref="UniProtKB/Swiss-Prot:Q796S4" /translation="MNTDHTKRNLFELYAELIHQQEKWEGLIKAFLSDELRKLDVEHG SKSQLTMTEIHVLSCVGDNEPINVTSIAEKMNTTKATVSRISTKLLGAGFLHRTQLSD NKKEVYFRLTPAGKKLHSLHKYYHQKAEQRFLSFFDRYTEEEILFAERLFRDLVTKWY PSSEEIEGGLPSIFK*" gene 1124438..1124965 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" downshifts 1124927 /Source="Nicolas_upshifts" /id="D574" /incds=0 /nref=8 /ntot=128 /MaxReadThrough="1.1509" /MaxDrop="3.41655" /score="11.3050978" /energy="-9.9" /TU="NA" /idTUdmin="U851" /TUdmin=8 /isTUend="TRUE" S_feature complement(1124979..1125122) /Source="Nicolas_S_feature" /locus_tag="new_1124979_1125122_c" /HighExp="B36, B60, T0.30H, LBGstat, T1.30H, T1.0H, LPhT, LBGtran, Diami, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S371" downshifts complement(1125017) /Source="Nicolas_upshifts" /id="D575" /incds=0 /nref=4 /ntot=72 /MaxReadThrough="1.20458" /MaxDrop="5.06167" /score="27.254423" /energy="-9.9" /TU="NA" /idTUdmin="U855" /TUdmin=0 /isTUend="TRUE" CDS complement(1125123..1126328) /gene="glcP" /locus_tag="BSU_10520" /old_locus_tag="BSU10520" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9457850, 15849754, 16850406, 17056753, 19087206" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9457850, 15849754, 16850406, 17056753, 19087206; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glucose/mannose:H+ symporter (recent HGT island)" /protein_id="NP_388933.1" /db_xref="EnsemblGenomes-Gn:BSU10520" /db_xref="EnsemblGenomes-Tr:CAB12892" /db_xref="GOA:O07563" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13075" /db_xref="UniProtKB/Swiss-Prot:O07563" /translation="MLRGTYLFGYAFFFTVGIIHISTGSLTPFLLEAFNKTTDDISVI IFFQFTGFLSGVLIAPLMIKKYSHFRTLTLALTIMLVALSIFFLTKDWYYIIVMAFLL GYGAGTLETTVGSFVIANFESNAEKMSKLEVLFGLGALSFPLLINSFIDINNWFLPYY CIFTFLFVLFVGWLIFLSKNREYAKNANQQVTFPDGGAFQYFIGDRKKSKQLGFFVFF AFLYAGIETNFANFLPSIMINQDNEQISLISVSFFWVGIIIGRILIGFVSRRLDFSKY LLFSCSCLIVLLIAFSYISNPILQLSGTFLIGLSIAGIFPIALTLASIIIQKYVDEVT SLFIASASFGGAIISFLIGWSLNQDTILLTMGIFTTMAVILVGISVKIRRTKTEDPIS LENKASKTQ*" gene complement(1125123..1126328) /gene="glcP" /locus_tag="BSU_10520" /old_locus_tag="BSU10520" promotor_-35 1125818..1125823 /Source="Nicolas_upshift_promotors" /id="U852" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1194 /SigmaFactorBS="tctcggttcttagacaagaaaattaaccaccctaCGAATAgg acgaataaaaaggtGAATATACAGTAATATGGTaaaaaccagttattgatatctatga a" /listShort="S372" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1125840..1125858 /Source="Nicolas_upshift_promotors" /id="U852" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1194 /SigmaFactorBS="tctcggttcttagacaagaaaattaaccaccctaCGAATAgg acgaataaaaaggtGAATATACAGTAATATGGTaaaaaccagttattgatatctatga a" /listShort="S372" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1125843..1126369 /Source="Nicolas_S_feature" /locus_tag="new_1125843_1126369" /HighExp="S4, S5, S6, S8, S7, S3, T5.0H, M9-stat, LBGstat, T4.0H" /AntisenseName="glcP" /AntisenseCor="-0.155079396671681" /AntisenseRegPval="-2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S372" upshifts 1125844 /Source="Nicolas_upshifts" /id="U852" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1194 /SigmaFactorBS="tctcggttcttagacaagaaaattaaccaccctaCGAATAgg acgaataaaaaggtGAATATACAGTAATATGGTaaaaaccagttattgatatctatga a" /listShort="S372" /GFF_Attribute="listLong" downshifts 1126327 /Source="Nicolas_upshifts" /id="D576" /incds=0 /nref=6 /ntot=59 /MaxReadThrough="2.40974" /MaxDrop="3.26024" /score="9.68585629" /energy="-9.4" /TU="NA" /idTUdmin="U852" /TUdmin=0 /isTUend="TRUE" CDS complement(1126400..1127452) /gene="ntdC" /locus_tag="BSU_10530" /old_locus_tag="BSU10530" /EC_number="1.1.1.-" /function="16.8: Protect" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14612444, 17056753, 23586652, 28353336" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612444, 17056753, 23586652, 28353336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose), glucose-6-P 3-dehydrogenase; kanosamine biosynthesis (recent HGT island)" /protein_id="NP_388934.2" /db_xref="EnsemblGenomes-Gn:BSU10530" /db_xref="EnsemblGenomes-Tr:CAB12893" /db_xref="GOA:O07564" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13076" /db_xref="UniProtKB/Swiss-Prot:O07564" /translation="MKKIGIIGAGGIARAHATALSTIKNAELVGVYDINQQNAESFVK TFGGKSFENVDELIDASEGLIVASPNFCHKEHALQALGKHKHVLCEKPMAISLEEASI MKDTAERLSVRASMGFNYRYLSYVNILKSLIINNELGNILSIKVHFKKNSALRRKKFT WRDDANSKKTSGSLGDLGIHLIDMVWYLFESDFITESVRAKMNTNVKTKEDKQVLVDD YAEIYGQLKNKVFVNIITSKCSVPEDCGFSIEVVGHKKEFKYHTGNPHVYKLIDGLNV VDCPVPQSLLNDPPNEFYGWADSFRSELINWIASTQNDWVEIPSFSDGFRSQEVLEMF FEKDSNSQPMSVSAVN*" gene complement(1126400..1127452) /gene="ntdC" /locus_tag="BSU_10530" /old_locus_tag="BSU10530" CDS complement(1127466..1128314) /gene="ntdB" /locus_tag="BSU_10540" /old_locus_tag="BSU10540" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14612444, 17056753, 23586652" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612444, 17056753, 23586652; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha, beta-trehalose);kanosamine-6-phosphate phosphatase (recent HGT island)" /protein_id="NP_388935.2" /db_xref="EnsemblGenomes-Gn:BSU10540" /db_xref="EnsemblGenomes-Tr:CAB12894" /db_xref="GOA:O07565" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR006380" /db_xref="InterPro:IPR036412" /db_xref="PDB:3GYG" /db_xref="SubtiList:BG13077" /db_xref="UniProtKB/Swiss-Prot:O07565" /translation="MLLSKKSEYKTLSTVEHPQYIVFCDFDETYFPHTIDEQKQQDIY ELEDYLEQKSKDGELIIGWVTGSSIESILDKMGRGKFRYFPHFIASDLGTEITYFSEH NFGQQDNKWNSRINEGFSKEKVEKLVKQLHENHNILLNPQTQLGKSRYKHNFYYQEQD EINDKKNLLAIEKICEEYGVSVNINRCNPLAGDPEDSYDVDFIPIGTGKNEIVTFMLE KYNLNTERAIAFGDSGNDVRMLQTVGNGYLLKNATQEAKNLHNLITDSEYSKGITNTL KKLIGS*" gene complement(1127466..1128314) /gene="ntdB" /locus_tag="BSU_10540" /old_locus_tag="BSU10540" CDS complement(1128286..1129611) /gene="ntdA" /locus_tag="BSU_10550" /old_locus_tag="BSU10550" /EC_number="2.6.1.-" /function="16.5: Explore" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14612444, 17056753, 19087206, 23586652, 24097983, 24509311, 28353336" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612444, 17056753, 19087206, 23586652, 24097983, 24509311, 28353336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha, beta-trehalose);3-oxo-glucose-6-phosphate:glutamate aminotransferase; kanosamine aminotransferase (recent HGT island)" /protein_id="NP_388936.1" /db_xref="EnsemblGenomes-Gn:BSU10550" /db_xref="EnsemblGenomes-Tr:CAB12895" /db_xref="GOA:O07566" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:4K2B" /db_xref="PDB:4K2I" /db_xref="PDB:4K2M" /db_xref="SubtiList:BG13078" /db_xref="UniProtKB/Swiss-Prot:O07566" /translation="MQKQVKISGKSKENMSLLKHLKGDVQGKELVIEDSIVNERWKQV LKEKIDIEHDLFNYQKNREISKVPFLPVDRLITNDEVEDILNTLTEVLPTGKFTSGPY LEQFEKVLSTYLHKRYVIATSSGTDAIMIGLLALGLNPGDEVIMPANSFSATENAVLA SGGVPIYVDINPQTFCIDPDKIEEAITPYTKFILPVHLYGKHSDMQHIRQIANRYKLK VIEDACQGIGLTDLGKYADITTLSFNPYKNFGVCGKAGAIATDNEELAKKCIQFSYHG FEVNVKNKKVINFGFNSKMDNLQAAIGLERMKYLSLNNFKRLFLADRYITQLAELQNK GYIELPELSEDHVWHLFPIKVRTEDRADIMTKLNEDFGVQTDVYYPILSHMQKTPLVQ DKYAGLQLVHTEKAHSQVLHLPLYPSFTLEEQDRVMEGLFHVIKQEIGV*" gene complement(1128286..1129611) /gene="ntdA" /locus_tag="BSU_10550" /old_locus_tag="BSU10550" promotor_-35 1128455..1128460 /Source="Nicolas_upshift_promotors" /id="U853" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1031 /SigmaFactorBS="cctgcatacttgtcctgtactaaaggagtttttTGCATAtga gaaagtattggaTAATATACATCTGTTTGAAcaccaaaatcttcatttaatttagtca t" /listShort="S373, S374, yhjM" /listLong="S375" /label="promotor_-35" promotor_-10 1128476..1128494 /Source="Nicolas_upshift_promotors" /id="U853" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1031 /SigmaFactorBS="cctgcatacttgtcctgtactaaaggagtttttTGCATAtga gaaagtattggaTAATATACATCTGTTTGAAcaccaaaatcttcatttaatttagtca t" /listShort="S373, S374, yhjM" /listLong="S375" /label="promotor_-10" S_feature 1128482..1129270 /Source="Nicolas_S_feature" /locus_tag="new_1128482_1129270" /HighExp="S4, S3, S5, S6, S7, T5.0H, M9-stat, S8, Pyr, G/S" /AntisenseName="ntdA" /AntisenseCor="-0.29559566742128002" /AntisenseRegPval="-6.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S373" upshifts 1128482 /Source="Nicolas_upshifts" /id="U853" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1031 /SigmaFactorBS="cctgcatacttgtcctgtactaaaggagtttttTGCATAtga gaaagtattggaTAATATACATCTGTTTGAAcaccaaaatcttcatttaatttagtca t" /listShort="S373, S374, yhjM" /listLong="S375" promotor_-35 1129246..1129253 /Source="Nicolas_upshift_promotors" /id="U854" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.776223776223776" /psig="0.998001998001998" /xcortree=2928 /SigmaFactorBS="ataaacctatcataatagcatcggttccactgctGGTTGCAA ttacataccttttaTGTAAATATGTAGATAAAACtttttcgaattgctctaaataggg a" /listShort="S374, yhjM, S375" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1129268..1129287 /Source="Nicolas_upshift_promotors" /id="U854" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.776223776223776" /psig="0.998001998001998" /xcortree=2928 /SigmaFactorBS="ataaacctatcataatagcatcggttccactgctGGTTGCAA ttacataccttttaTGTAAATATGTAGATAAAACtttttcgaattgctctaaataggg a" /listShort="S374, yhjM, S375" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1129272..1129714 /Source="Nicolas_S_feature" /locus_tag="new_1129272_1129714" /HighExp="T4.0H, T3.0H, T2.30H, HiOs, T3.30H, T2.0H, T5.0H, T1.30H, LoTm, T-1.10H" /AntisenseName="ntdA" /AntisenseCor="-0.101471720232752" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.998, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S374" upshifts 1129272 /Source="Nicolas_upshifts" /id="U854" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.776223776223776" /psig="0.998001998001998" /xcortree=2928 /SigmaFactorBS="ataaacctatcataatagcatcggttccactgctGGTTGCAA ttacataccttttaTGTAAATATGTAGATAAAACtttttcgaattgctctaaataggg a" /listShort="S374, yhjM, S375" /GFF_Attribute="listLong" promotor_-10 complement(1129646..1129665) /Source="Nicolas_upshift_promotors" /id="U855" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.849150849150849" /psig="0.97902097902098" /xcortree=1578 /SigmaFactorBS="gcatattttcccttccttaaaaaagttgttgaCATGTTACcg atttcagaaacTAGGATAAATTTGTAATAAAtttttagattataaaatcattggaggt a" /listShort="ntdA, ntdB, ntdC, glcP, S371" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1129658) /Source="Nicolas_upshifts" /id="U855" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.849150849150849" /psig="0.97902097902098" /xcortree=1578 /SigmaFactorBS="gcatattttcccttccttaaaaaagttgttgaCATGTTACcg atttcagaaacTAGGATAAATTTGTAATAAAtttttagattataaaatcattggaggt a" /listShort="ntdA, ntdB, ntdC, glcP, S371" /GFF_Attribute="listLong" promotor_-35 complement(1129679..1129686) /Source="Nicolas_upshift_promotors" /id="U855" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.849150849150849" /psig="0.97902097902098" /xcortree=1578 /SigmaFactorBS="gcatattttcccttccttaaaaaagttgttgaCATGTTACcg atttcagaaacTAGGATAAATTTGTAATAAAtttttagattataaaatcattggaggt a" /listShort="ntdA, ntdB, ntdC, glcP, S371" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1129715..1130704 /gene="ntdR" /locus_tag="BSU_10560" /old_locus_tag="BSU10560" /experiment="publication(s) with functional evidences, PMID:14612444, 17056753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612444, 17056753; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the ntd operon (NtdR-NTD) (recent HGT island)" /protein_id="NP_388937.1" /db_xref="EnsemblGenomes-Gn:BSU10560" /db_xref="EnsemblGenomes-Tr:CAB12896" /db_xref="GOA:O07567" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13079" /db_xref="UniProtKB/Swiss-Prot:O07567" /translation="MPTIDEIAKLCNVSKTTVSRVLNNHPYVSKEKRDMILKAINELD YTPNYLARNFRRNKTQTIALSVPSIDHPFFAQLIKGVSHEVLFKNYKVIVFQTFYDKQ TELELLELLKHKEVDGIILGTLENEWDQISPFLKYGPILLCNEYHHSADITIIGYDEF EAAYMGVVHLIERGHKKIGFCFDTPYSEAQCQRKEGYLKALQDYNLHHRSEWIFGEMF NIEDGFRVFHKIKDLKDRPSAIFTGNDQVAAGIIKQAMKNGFKVPEDLAVIGFDNQLI CQVVTPTITTIDIPVIELGQQAVLKIIESISGNASLNRRIIKLPTKLIIREST*" gene 1129715..1130704 /gene="ntdR" /locus_tag="BSU_10560" /old_locus_tag="BSU10560" S_feature 1130705..1131082 /Source="Nicolas_S_feature" /locus_tag="new_1130705_1131082" /HighExp="T4.0H, T5.0H, T3.30H, T2.0H, HiOs, T2.30H, T3.0H, LoTm, T1.30H, Pyr" /AntisenseName="yhjN" /AntisenseCor="-5.0383887616073E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig="0.997" /label="S375" S_feature complement(1130759..1130917) /Source="Nicolas_S_feature" /locus_tag="new_1130759_1130917_c" /HighExp="B60, Sw, Cold, B36, BI, GM 15, GM 10, C30, GM 25, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S376" downshifts complement(1130802) /Source="Nicolas_upshifts" /id="D577" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="3.07371" /MaxDrop="4.24831" /score="-1.9470655" /energy="-7.1" /TU="U856" /idTUdmin="U856" /TUdmin="-66" /isTUend="FALSE" CDS complement(1130918..1132072) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (recentHGT island)" /protein_id="NP_388938.1" /db_xref="EnsemblGenomes-Gn:BSU10570" /db_xref="EnsemblGenomes-Tr:CAB12897" /db_xref="GOA:O07568" /db_xref="InterPro:IPR007820" /db_xref="InterPro:IPR017516" /db_xref="SubtiList:BG13080" /db_xref="UniProtKB/Swiss-Prot:O07568" /translation="MKKDENLLKDLWFIAISAAGGFILSLTGISIGWMIGTLIVACCL AMIRPAWLMMAPDQKGINRRWLALGQMILGIELGQKLNLSVLSVLKDHWFSVGVMLIL SILLAMLSGYVLWRFSKTDMMTSFVGTAPGGLSAMPSIAQEVGANTAIVSLVQMMRVL LVVLSIPFLVILIYTKQDRTASAAAETISSATTDFRLAPVLWTVILILAAWGACKAAK FLKFPAPWLLGSMLGVAIVHVGGAAVTGHDMTAWWLSQANHVSQVFLGATIGSKMYKS MFAGVTRIIIVGFVSSVGLIAAMFLSAVIVSELTGISLITSVLAFAPGGIAEMATTSV TLHADSTFVVAVQVIRVILVIALLPPFYRLLHHLHGEKKDKKSSISGSSA*" gene complement(1130918..1132072) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" S_feature complement(1132073..1132144) /Source="Nicolas_S_feature" /locus_tag="new_1132073_1132144_c" /HighExp="Cold, GM 15, GM 10, dia15, BC, BI, Salt, B60, Sw, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S377" promotor_-10 complement(1132127..1132146) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1132143) /Source="Nicolas_upshifts" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" promotor_-35 complement(1132160..1132165) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1132179..1133384) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease (recent HGT island)" /protein_id="NP_388939.1" /db_xref="EnsemblGenomes-Gn:BSU10580" /db_xref="EnsemblGenomes-Tr:CAB12898" /db_xref="GOA:O07569" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13081" /db_xref="UniProtKB/Swiss-Prot:O07569" /translation="MLTSFHSIKSRYTAPVRLRFFGELLTSLTGAMMGPFMVLYLHEQ LNGSIMMPMLIISLQPFADIFLTLAAGRVTDRLGRRTAILTALLLQSAAMTGFVFAEH AYVFAILYVMNGIGRSLYIPASRAQIAESTPESRRSEVFAVINAIYSTGLTAGPLVGM LLYNHNPVWIFALDAAALFIYFLIAALKLPETKPLHPAVTPKMSASFTIYRPVLLLLL LSLPISMLYAQTETTYRLFSKNMFSDYLSMLTIYSAAKALFSCVLQVPLVKGTEKLSM KTILFITYICYSLAAAGFACSTSLTMLLVTAAVMTVGESIGLTHIQTFISKLAPPHLL GRFYAVYGLHWDISRSIGPLAGGLILTSFGGEVIFYALAVCLLTAGLSLTYTIEKLEH KVIRKVNRL*" gene complement(1132179..1133384) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" misc_feature 1133405..1133424 /Source="Nicolas_upshift_promotors" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1133410 /Source="Nicolas_upshifts" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1133498..1135225 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcription factor" /protein_id="NP_388940.1" /db_xref="EnsemblGenomes-Gn:BSU10590" /db_xref="EnsemblGenomes-Tr:CAB12899" /db_xref="GOA:O07570" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR025370" /db_xref="InterPro:IPR030678" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13082" /db_xref="UniProtKB/Swiss-Prot:O07570" /translation="MKLIEHYVALVKTGCAEYGQMNEMTLTEIADCLFCTERNAKLIL HKLENSNWIIRESGAGRGRKSKIAFLRRPEELLLQTAKEYTMSGKLKKAKELLQQYQS AFPGLQNEYNMWLSEVFGFVTETGENGAKDVLRLFITPESVSSLDPCQIFLRSEGHFV KQIFDTLFTFDSDMQEPKPHLVHGWEEVGKKQWRFFLRKGVLFHNGQPLTSRDVAFTF QRFLELADNPYKWLLHGVKQVLEKGPYCVELILDKPNALLPYALCDERLSILPAEQGG GKNGTGPFQMNQQHSGMLVLEANERYFKGRPYLDRVEFVFSEQAGEMNGFTIQEKQTC PEQQTVFDERHVQYLSLNLKKKGPLQHRSFRKALRLLISSERLVREAGGHRRIPVTSF LHPSPFEWEGVSPSELLKKSGYEGETIVLYTFSETDHREDAEWIQNICAQHGIRLTLQ FCDAADLRRPEIVQMADIIHDSATFYQDSEFGFLHLLLSENSFLYQHLSEKLTQICSG MTERMFSMPDRCSRINILRDIDRQMIQELNAIPLYQNVLQVTSSKNVKGLVLDEEGWI DLYSVWLSK*" gene 1133498..1135225 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" promotor_-35 1134811..1134818 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1134833..1134852 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1134840 /Source="Nicolas_upshifts" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(1135255..1135581) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12625841; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative metal-chelating cysteine-rich protein of unknown function" /protein_id="NP_388941.1" /db_xref="EnsemblGenomes-Gn:BSU10600" /db_xref="EnsemblGenomes-Tr:CAB12900" /db_xref="InterPro:IPR005560" /db_xref="PDB:5FIG" /db_xref="SubtiList:BG13083" /db_xref="UniProtKB/Swiss-Prot:O07571" /translation="MEQYSEACIEACIDCMKACNHCFTKCLEESVQHHLSGCIRLDRE CADICALAVKAMQTDSPFMKEICALCADICEACGTECGKHDHDHCQACAKACFTCAEQ CRSMAA*" gene complement(1135255..1135581) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" CDS complement(1135699..1136136) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22078549, 22882546; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative electron carrier protein (putative sporulation gene)" /protein_id="NP_388942.1" /db_xref="EnsemblGenomes-Gn:BSU10610" /db_xref="EnsemblGenomes-Tr:CAB12901" /db_xref="GOA:O07572" /db_xref="InterPro:IPR003251" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13084" /db_xref="UniProtKB/Swiss-Prot:O07572" /translation="MHYSYYPYPVPYREDPVLIRNLQKAINGEFSAIQCYRKLAELAH SDEVRKQIEEIRRDEIRHLREFSTLYGSITGKHIMPKQTEECPDNFTRGLDAAFKDEQ ETVDFYLRAAEETSNLKAKGVFTRAARDEQNHAVWFLYYLMER*" gene complement(1135699..1136136) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" downshifts complement(1135708) /Source="Nicolas_upshifts" /id="D578" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.72767" /MaxDrop="3.86885" /score="16.2430017" /energy="-11.5" /TU="U859" /idTUdmin="U859" /TUdmin="-440" /isTUend="FALSE" promotor_-10 complement(1136167..1136186) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1136187) /Source="Nicolas_upshifts" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" promotor_-35 complement(1136199..1136208) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1136256..1136263 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1136277..1136296 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1136289 /Source="Nicolas_upshifts" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" CDS 1136320..1139820 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit B)" /protein_id="NP_388943.2" /db_xref="EnsemblGenomes-Gn:BSU10620" /db_xref="EnsemblGenomes-Tr:CAB12902" /db_xref="GOA:P23477" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014140" /db_xref="InterPro:IPR027417" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10465" /db_xref="UniProtKB/Swiss-Prot:P23477" /translation="MGAEFLVGRSGSGKTKLIINSIQDELRRAPFGKPIIFLVPDQMT FLMEYELAKTPDMGGMIRAQVFSFSRLAWRVLQHTGGMSRPFLTSTGVQMLLRKLIEE HKQEFKVYQKASDKSGFTAQVERMLTEFKRYCLEPEDIRRMAESGTASEYRGERVLSE KLHDLSILYQQMEKSLADQYLHSEDYLTLLAEHIPLAEDIKGAHIYVDGFYQFTPQEF RVLEQLMVHAEHITFSLTADKPSYEREPHELELFRMTGKTYYRLHQKAKELNLDITYK ELSGTERHTKTPELAHLEAQYEARPAIPYAEKQEALTVMQAANRRAELEGIAREIHAL VREKGYRYKDVAILARQPEDYKDMVKEVFADYEIPYFIDGKASMLNHPLIEFIRSSLD VLKGNWRYEAVFRCVKTELLFPLNEPKAKVREQVDQLENYCIAYGIKGDRWTKGDRFQ YRRFVSLDDDFAQTDQEIEMENMLNDTRDWIVPPLFQLQKRMKKAKTVQEKAEALYRY LEETDVPLKLDQERQRAEDDGRIIEAQQHQQAWDAVIQLLEEFVEMMGDDEISLDLFQ QMIEAGAESLTFSLIPPALDQVFVGNMDLSRMYGTSCTFVLGANDGVLPARPDENGVL SDDDREWLKTIGVELSSGGRERLLDEHFLIYMAFSSPSDRLYVSYPIADAEGKTLLPS MIVKRLEELFPHHKERLLTNEPEQVSDEEQLMYVVNKSVAQSFTASQLRLWTREYDIS DVWWSTYNVLMSEQDRLQSKKLFSSLFFRNEVKQLERSVSRQLYGERIQGSVSRMETF NACPFSHFASHGLHLKERQFFKLEAPDIGQLFHSSLKLISDRLREQKLDWRDLTKEQC ELFSYDAVERLAPKLQKEILLSSNRHYYVKEKLQKIVTRVSGILSEHAKASGFVPIGL ELGFGGKGPLPPLTFQLKNGCTMELVGRIDRVDKAESSKGLLLRIVDYKSSDKGLDLA EVYYGLALQMLTYLDLSITHSADWLGMRATPAGVLYFHIHDPMIQSNLPLGLDEIEQE IFKKFKMKGLLLGDQEVVRLMDTTLQEGRSNIINAGLKKDGSLRSDSAAVGEKEFDLL TKHVRRTFQEAGEQITDGRVSIEPYKMKNKTPCTYCAFKSVCQFDESLEENEYRPLKA EKDKTILEWIKKEADGNEHS*" gene 1136320..1139820 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" CDS 1139807..1143505 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit A)" /protein_id="NP_388944.2" /db_xref="EnsemblGenomes-Gn:BSU10630" /db_xref="EnsemblGenomes-Tr:CAB12903" /db_xref="GOA:P23478" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR011335" /db_xref="InterPro:IPR011604" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014152" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10466" /db_xref="UniProtKB/Swiss-Prot:P23478" /translation="MNIPKPADSTWTDDQWNAIVSTGQDILVAAAAGSGKTAVLVERM IRKITAEENPIDVDRLLVVTFTNASAAEMKHRIAEALEKELVQRPGSLHIRRQLSLLN RASISTLHSFCLQVLKKYYYLIDLDPGFRIADQTEGELIGDEVLDELFEDEYAKGEKA FFELVDRYTTDRHDLDLQFLVKQVYEYSRSHPNPEAWLESFVHLYDVSEKSAIEELPF YQYVKEDIAMVLNGAKEKLLRALELTKAPGGPAPRADNFLDDLAQIDELIQHQDDFSE LYKRVPAVSFKRAKAVKGDEFDPALLDEATDLRNGAKKLLEKLKTDYFTRSPEQHLKS LAEMKPVIETLVQLVISYGKRFEAAKQEKSIIDFSDLEHYCLAILTAENDKGEREPSE AARFYQEQFHEVLVDEYQDTNLVQESILQLVTSGPEETGNLFMVGDVKQSIYRFRLAE PLLFLSKYKRFTESGEGTGRKIDLNKNFRSRADILDSTNFLFKQLMGGKIGEVDYDEQ AELKLGAAYPDNDETETELLLIDNAEDTDASEEAEELETVQFEAKAIAKEIRKLISSP FKVYDGKKKTHRNIQYRDIVILLRSMPWAPQIMEELRAQGIPVYANLTSGYFEAVEVA VALSVLKVIDNPYQDIPLASVLRSPIVGADENELSLIRLENKKAPYYEAMKDYLAAGD RSDELYQKLNTFYGHLQKWRAFSKNHSVSELIWEVYRDTKYMDYVGGMPGGKQRQANL RVLYDRARQYESTAFRGLFRFLRFIERMQERGDDLGTARALSEQEDVVRLMTIHSSKG LEFPVVFVAGLGRNFNMMDLNKSYLLDKELGFGTKYIHPQLRISYPTLPLIAMKKKMR RELLSEELRVLYVALTRAKEKLFLIGSCKDHQKQLAKWQASASQTDWLLPEFDRYQAR TYLDFIGPALARHRDLGDLAGVPAHADISGHPARFAVQMIHSYDLLDDDLEERMEEKS ERLEAIRRGEPVPGSFAFDEKAREQLSWTYPHQEVTQIRTKQSVSEIKRKREYEDEYS GRAPVKPADGSILYRRPAFMMKKGLTAAEKGTAMHTVMQHIPLSHVPSIEEAEQTVHR LYEKELLTEEQKDAIDIEEIVQFFHTEIGGQLIGAKWKDREIPFSLALPAKEIYPDAH EADEPLLVQGIIDCLYETEDGLYLLDYKSDRIEGKFQHGFEGAAPILKKRYETQIQLY TKAVEQIAKTKVKGCALYFFDGGHILTL*" gene 1139807..1143505 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" S_feature 1143506..1143576 /Source="Nicolas_S_feature" /locus_tag="new_1143506_1143576" /HighExp="H2O2, C90, Heat, LBGtran, dia15, HiTm, Diami, C30, Lbtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S378" CDS 1143577..1144752 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7968921, 8493111, 16780573" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7968921, 8493111, 16780573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair exonuclease" /protein_id="NP_388945.3" /db_xref="EnsemblGenomes-Gn:BSU10640" /db_xref="EnsemblGenomes-Tr:CAB12904" /db_xref="GOA:P23479" /db_xref="InterPro:IPR004593" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR026843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG10467" /db_xref="UniProtKB/Swiss-Prot:P23479" /translation="MRILHTADWHLGKTLEGRSRLSEQADVLDELNTIVKDEQIDAIV MAGDAFDTVNPPALAEQLFYESLSALSDRGKRPIVVIAGNHDNPDRLSAASPLTHENG IHLIGYPTTEPIHIEVPSAGELLAVGALAYPSEARLNEVLSDTFDEKLLRDHYDVKIR QAFEHMTSRFRTDAVKIAASHIYVAGGNQTDSERPIEVGGAYTVAAESLPADAAYVAL GHLHRPQTIKRARTLARYSGSPLAYSFSEAGYAKSVTIVDAKPGEEATWQEVLLSSGK PLVKWKAANGLSEVYSWLDEGRDQNAWIDLEIRVADQLSLEEIHRLRKAHPGFIHIRP VFEEQNKDRERIEVKHVSIEDRFKKFYEKQTGGAVPDEEMVKLFLELASGVEEEDAK* " gene 1143577..1144752 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" CDS 1144749..1148141 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 19906728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 19906728; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ATP-dependent repair enzyme" /protein_id="NP_388946.2" /db_xref="EnsemblGenomes-Gn:BSU10650" /db_xref="EnsemblGenomes-Tr:CAB12905" /db_xref="GOA:O06714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13088" /db_xref="UniProtKB/Swiss-Prot:O06714" /translation="MKPIALSIKGLHSFREEQTIDFEGLSGAGVFGIFGPTGSGKSSI LDAMTLALYGKVERAANNTHGILNHAEDTLSVSFTFALQTNHQISYKVERVFKRTDEM KVKTALCRFIEIKDEHTVLADKASEVNKRVEELLGLTIDDFTRAVVLPQGKFAEFLSL KGAERRHMLQRLFNLEQYGDRLVKKLRRQAQEANARKNEMLAEQSGLGEASSEAVEQA EKVLEQAEARLEAMRKNRDQAKERFTEHQEIWNVQKEKSTYEEEEKRLAEEQPHIDSM QKRLLEAETAAALKPYADRYAEAIQHEEQAEKEQTLAQKDLADRTAFFQQKHEEYEAW RQHKSEKEPELLAKQEQLSRLQEIEIKLSEAKQEEERKKADLRQKEEALQSVMNELET VTDRLTRGQNRQTELKQQLKSLQVTSDERKSCQQAAEMALRIRQTEEQIKKEKKRSEE LNLVLQKMNEEKNTLVQKTEAEENNIIQAYEAVQTVYHLVCETERSLTRMTEEARKSQ HTLHLQREKARVALLTKELAQKLTAGKPCPVCGSTDHDPSASVHETYEADSHLEEDIK RTDVLLTEAAALSQEILSAKIMLEEQSARFIEQCPFLQTIQAQNLEAAASFEHQPVYE AFETAKFEWKRIKQDILSVKTRMAQMIGAYQESLKKAEQLNEKIGFEKREADRIESII SELQSSMDSSLNMFKEAFQNQSVDEAEKWQQAIEEKDRAAEECEKRIEKSIAFLAEHE AQKEKLRESGHRLEREKLELHYAAERIKSVIADYEHELGDYAKGDSIQIKLRSVQQDL KLLKEKEQSLYEELQSAQMKLNQAKSRASASELTLQEAKGRLEKAKAAWLEHTKNTSI TRTEEVEQSLIPADELEKMKTGIDQFMDKLKQNAANLKRVAEILAGRALSESEWNETV AALQEAEDAFGAAIEEKGAAAKALAVIRDHHKRFNEIEAELKKWQMHIDRLDKLQAVF KGNTFVEFLAEEQLESVARDASARLSMLTRQRYAIEVDSEGGFVMRDDANGGVRRPVS SLSGGETFLTSLSLALALSAQIQLRGEYPLQFFFLDEGFGTLDQDLLDTVVTALEKLQ SDNLAVGVISHVQELRARLPKKLIVHPAEPSGRGTRVSLELM*" gene 1144749..1148141 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" promotor_-35 1147396..1147402 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1147417..1147428 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1147424 /Source="Nicolas_upshifts" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" S_feature complement(1147493..1148466) /Source="Nicolas_S_feature" /locus_tag="new_1147493_1148466_c" /HighExp="S6, S8, S7, BT, C30, B36, S5, C90, Pyr, B60" /AntisenseName="yisB" /AntisenseCor="0.19649597897587401" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="SigK" /TUlongPSig="0.992" /label="S379" CDS 1148155..1148457 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 22984257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 22984257; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="HNH nuclease-like essential for DNA repair" /protein_id="NP_388947.1" /db_xref="EnsemblGenomes-Gn:BSU10660" /db_xref="EnsemblGenomes-Tr:CAB12906" /db_xref="SubtiList:BG13089" /db_xref="UniProtKB/Swiss-Prot:O06715" /translation="MAKQIAGICELCGRSDVQLTEHHLTPKEEGGTFLPTAMLCIPCH KQIHALYTNQELAVRLNGMAELRSDPELARFVKWIRKQPPEKLIKTKKSNERKKKK*" gene 1148155..1148457 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" downshifts 1148437 /Source="Nicolas_upshifts" /id="D579" /incds=0 /nref=230 /ntot=269 /MaxReadThrough="1.42126" /MaxDrop="6.71114" /score="0.317490594" /energy="-14.3" /TU="NA" /idTUdmin="U861" /TUdmin=1 /isTUend="TRUE" CDS complement(1148494..1148712) /gene="gerPF" /locus_tag="BSU_10670" /old_locus_tag="BSU10670" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007, 20161744" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007, 20161744; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388948.2" /db_xref="EnsemblGenomes-Gn:BSU10670" /db_xref="EnsemblGenomes-Tr:CAB12907" /db_xref="GOA:O06716" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13090" /db_xref="UniProtKB/Swiss-Prot:O06716" /translation="MPAIVGPIAINSISGGVVNFGDSFYLSPKSSSKSALGSGAGNTG DFLLLNNAVNATNYIDPDVNDQDMVGNG*" gene complement(1148494..1148712) /gene="gerPF" /locus_tag="BSU_10670" /old_locus_tag="BSU10670" downshifts complement(1148511) /Source="Nicolas_upshifts" /id="D580" /incds=0 /nref=40 /ntot=66 /MaxReadThrough="3.93344" /MaxDrop="5.39228" /score="13.5435041" /energy="-15.3" /TU="U863" /idTUdmin="U863" /TUdmin="-989" /isTUend="FALSE" CDS complement(1148744..1149145) /gene="gerPE" /locus_tag="BSU_10680" /old_locus_tag="BSU10680" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388949.1" /db_xref="EnsemblGenomes-Gn:BSU10680" /db_xref="EnsemblGenomes-Tr:CAB12908" /db_xref="GOA:O06717" /db_xref="InterPro:IPR024496" /db_xref="SubtiList:BG13091" /db_xref="UniProtKB/Swiss-Prot:O06717" /translation="MLKRISRIRLVKFNSLGIASVFQVGDTNEIDMSVKVFAVQRSLS TFYHNEGSFNKKEYQIFQQQAVKPLPETGVQSAFCHEVPAIYVRSIKIQGVSASSVLH AGSASLIRGDARLKHIRQIQSPRSQSPAKNI*" gene complement(1148744..1149145) /gene="gerPE" /locus_tag="BSU_10680" /old_locus_tag="BSU10680" CDS complement(1149145..1149321) /gene="gerPD" /locus_tag="BSU_10690" /old_locus_tag="BSU10690" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388950.1" /db_xref="EnsemblGenomes-Gn:BSU10690" /db_xref="EnsemblGenomes-Tr:CAB12909" /db_xref="GOA:O06718" /db_xref="InterPro:IPR017257" /db_xref="SubtiList:BG13092" /db_xref="UniProtKB/Swiss-Prot:O06718" /translation="MIFTVINRSLEVGDIRMNGVSSSSVFHIGDTESIYLSSIFDTPP ESLIIGPFAPLAPE*" gene complement(1149145..1149321) /gene="gerPD" /locus_tag="BSU_10690" /old_locus_tag="BSU10690" CDS complement(1149318..1149935) /gene="gerPC" /locus_tag="BSU_10700" /old_locus_tag="BSU10700" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388951.1" /db_xref="EnsemblGenomes-Gn:BSU10700" /db_xref="EnsemblGenomes-Tr:CAB12910" /db_xref="GOA:O06719" /db_xref="InterPro:IPR019673" /db_xref="SubtiList:BG13093" /db_xref="UniProtKB/Swiss-Prot:O06719" /translation="MYDQSVSSYLQNLNSFVQQQAIHIQQLERQLKEIQTEMNTMKQR PATTIERVEYKFDQLKIERLDGTLNIGLNPTDPNSVQNFDVSQSTPQIGMMQQEESAQ LMQQIRQNVDMYLTEEIPDILEQLENQYDSRLDDTNRHHVIEDIRKQMDSRIHYYMSH IKKEENTPPAQYAEHIAEHVKRDVIRAVEHFLEHIPSEMKGDEQA*" gene complement(1149318..1149935) /gene="gerPC" /locus_tag="BSU_10700" /old_locus_tag="BSU10700" CDS complement(1149958..1150191) /gene="gerPB" /locus_tag="BSU_10710" /old_locus_tag="BSU10710" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388952.2" /db_xref="EnsemblGenomes-Gn:BSU10710" /db_xref="EnsemblGenomes-Tr:CAB12911" /db_xref="GOA:O06720" /db_xref="InterPro:IPR024255" /db_xref="SubtiList:BG13094" /db_xref="UniProtKB/Swiss-Prot:O06720" /translation="MNFYINQTIQINYLRLESISNSSILQIGSAGSIKSLSNLYNTGS YVEPAPEVSGSGQPLQLQEPDTGSLVPLQPPGR*" gene complement(1149958..1150191) /gene="gerPB" /locus_tag="BSU_10710" /old_locus_tag="BSU10710" CDS complement(1150206..1150427) /gene="gerPA" /locus_tag="BSU_10720" /old_locus_tag="BSU10720" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388953.1" /db_xref="EnsemblGenomes-Gn:BSU10720" /db_xref="EnsemblGenomes-Tr:CAB12912" /db_xref="GOA:O06721" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13095" /db_xref="UniProtKB/Swiss-Prot:O06721" /translation="MPAIVGAFKINAIGTSGVVHIGDCITISPQAQVRTFAGAGSFNT GDSLKVMNYQNATNVYDNDAVDQPIVANA*" gene complement(1150206..1150427) /gene="gerPA" /locus_tag="BSU_10720" /old_locus_tag="BSU10720" S_feature complement(1150428..1150514) /Source="Nicolas_S_feature" /locus_tag="new_1150428_1150514_c" /HighExp="S6, S8, S7, S5, BT, B36, B60, G/S, Pyr, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="SigK" /TUlongPSig="0.992" /label="S380" promotor_-35 1150442..1150448 /Source="Nicolas_upshift_promotors" /id="U862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.733266733266733" /xcortree=136 /SigmaFactorBS="aaacgctccgacaatggccggcatacgagcacatccttTGTT GAAaaattaaaaaaagACAGGTAAAGTGAAATGACAattccgatttcaattgggctat t" /listShort="S381, S385" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1150462..1150481 /Source="Nicolas_upshift_promotors" /id="U862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.733266733266733" /xcortree=136 /SigmaFactorBS="aaacgctccgacaatggccggcatacgagcacatccttTGTT GAAaaattaaaaaaagACAGGTAAAGTGAAATGACAattccgatttcaattgggctat t" /listShort="S381, S385" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1150464..1151119 /Source="Nicolas_S_feature" /locus_tag="new_1150464_1151119" /HighExp="Salt, BC, Sw, S8, Heat, M9-stat, S7, Etha, BMM, Lbtran" /AntisenseName="yisI" /AntisenseCor="3.97396613023396E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="0.17396" /TUshortSig="SigA" /TUshortPSig="0.733" /TUlongSig="NA" /TUlongPSig="NA" /label="S381" upshifts 1150464 /Source="Nicolas_upshifts" /id="U862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.733266733266733" /xcortree=136 /SigmaFactorBS="aaacgctccgacaatggccggcatacgagcacatccttTGTT GAAaaattaaaaaaagACAGGTAAAGTGAAATGACAattccgatttcaattgggctat t" /listShort="S381, S385" /GFF_Attribute="listLong" promotor_-10 complement(1150501..1150520) /Source="Nicolas_upshift_promotors" /id="U863" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1293 /SigmaFactorBS="ttcacaaagagccgatatgtccccttaaaattTCTCTCACAC atatgtgcgtttGTCATAAGCTATCGTGAATAgcccaattgaaatcggaattgtcatt t" /listShort="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1150514) /Source="Nicolas_upshifts" /id="U863" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1293 /SigmaFactorBS="ttcacaaagagccgatatgtccccttaaaattTCTCTCACAC atatgtgcgtttGTCATAAGCTATCGTGAATAgcccaattgaaatcggaattgtcatt t" /listShort="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /GFF_Attribute="listLong" S_feature complement(1150516..1150645) /Source="Nicolas_S_feature" /locus_tag="new_1150516_1150645_c" /HighExp="S6, S8, S7, T5.0H, T3.30H, T4.0H, S5, T3.0H, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S382" promotor_-35 complement(1150533..1150542) /Source="Nicolas_upshift_promotors" /id="U863" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1293 /SigmaFactorBS="ttcacaaagagccgatatgtccccttaaaattTCTCTCACAC atatgtgcgtttGTCATAAGCTATCGTGAATAgcccaattgaaatcggaattgtcatt t" /listShort="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1150647..1150849) /Source="Nicolas_S_feature" /locus_tag="new_1150647_1150849_c" /HighExp="T5.0H, T4.0H, T3.30H, S6, M9-stat, T3.0H, S8, S7, T2.30H, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.976, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S383" downshifts complement(1150690) /Source="Nicolas_upshifts" /id="D581" /incds=0 /nref=13 /ntot=116 /MaxReadThrough="3.97434" /MaxDrop="3.59184" /score="13.5435041" /energy="-15.3" /TU="U865" /idTUdmin="U864" /TUdmin=0 /isTUend="TRUE" CDS complement(1150850..1151020) /gene="pchI" /locus_tag="BSU_10730" /old_locus_tag="BSU10730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11679073, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11679073, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Spo0A-P phosphatase (iron-metabolism related)" /protein_id="NP_388954.1" /db_xref="EnsemblGenomes-Gn:BSU10730" /db_xref="EnsemblGenomes-Tr:CAB12913" /db_xref="GOA:O06722" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG13096" /db_xref="UniProtKB/Swiss-Prot:O06722" /translation="MNSKIEEMRITLIETAQKYGMNSKETIQCSQELDILLNTRIKEE MIFGRYLENSRM*" gene complement(1150850..1151020) /gene="pchI" /locus_tag="BSU_10730" /old_locus_tag="BSU10730" misc_feature complement(1151064..1151083) /Source="Nicolas_upshift_promotors" /id="U864" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.386613386613387" /psig="0.976023976023976" /xcortree=2921 /SigmaFactorBS="gcttttttagtcaaattgacgaaaggcaaccttttgagccaa aaTAGGTTATACTAACGATATCctgtatttatatcaaaataaaatctagaattggaga t" /listShort="yisI, S383" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1151067) /Source="Nicolas_upshifts" /id="U864" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.386613386613387" /psig="0.976023976023976" /xcortree=2921 /SigmaFactorBS="gcttttttagtcaaattgacgaaaggcaaccttttgagccaa aaTAGGTTATACTAACGATATCctgtatttatatcaaaataaaatctagaattggaga t" /listShort="yisI, S383" /GFF_Attribute="listLong" S_feature complement(1151069..1151165) /Source="Nicolas_S_feature" /locus_tag="new_1151069_1151165_c" /HighExp="S6, S8, S7, S5, BT, Pyr, G/S, Glucon, SMMPr, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S384" downshifts 1151076 /Source="Nicolas_upshifts" /id="D582" /incds=0 /nref=3 /ntot=54 /MaxReadThrough="4.52913" /MaxDrop="3.35342" /score="12.6645711" /energy="-10.3" /TU="U862" /idTUdmin="U862" /TUdmin="-176" /isTUend="FALSE" S_feature 1151121..1151285 /Source="Nicolas_S_feature" /locus_tag="new_1151121_1151285" /HighExp="Salt, S8, S7, BC, Heat, H2O2, Sw, Oxctl, MG-0.2, MG-0.1" /AntisenseName="yisJ" /AntisenseCor="0.24461808844813801" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.733" /TUlongSig="NA" /TUlongPSig="NA" /label="S385" CDS complement(1151166..1152089) /gene="yisJ" /locus_tag="BSU_10740" /old_locus_tag="BSU10740" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein, CotH paralog" /protein_id="NP_388955.1" /db_xref="EnsemblGenomes-Gn:BSU10740" /db_xref="EnsemblGenomes-Tr:CAB12914" /db_xref="GOA:O06723" /db_xref="InterPro:IPR014867" /db_xref="SubtiList:BG13097" /db_xref="UniProtKB/Swiss-Prot:O06723" /translation="MERVHLFFHREQLKRKGTAKGLFVTDRSVSPILLTQRDRAEKAS YEISWEKSLLGERTLFLNAEQDDPSLMRRRLAYCFFDQIGVPAPVASYSFLTINGQPE GIYLNIKNHQPAGKRSYGVKTADPRVPLSLFNNDSSAFLHEFFILIRTAGDDELAERI KLYLDVKLFFLWLIGNTCTNQGFYYTFCLNESGRLYVSPMETRSLAVQEWYEEDPLLT KGKTLSSRLLSIPAFRSQYHTLMKNVLKRSFTIERLSPLINEWHLDICQSAADDPFIK KSPFQIEKEQTNILREIEERQDFLQAHLARL*" gene complement(1151166..1152089) /gene="yisJ" /locus_tag="BSU_10740" /old_locus_tag="BSU10740" promotor_-10 complement(1152111..1152130) /Source="Nicolas_upshift_promotors" /id="U865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1372 /SigmaFactorBS="aaatccctttttctcaattccgttttcatTTCGTTTCAGgac gggcttgctcTACATATCATACAAATGTCGttttgagaaggaggaaagaatatggagc g" /listShort="yisJ, S384, yisI, S383, S382" /listLong="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /label="promotor_-10" upshifts complement(1152122) /Source="Nicolas_upshifts" /id="U865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1372 /SigmaFactorBS="aaatccctttttctcaattccgttttcatTTCGTTTCAGgac gggcttgctcTACATATCATACAAATGTCGttttgagaaggaggaaagaatatggagc g" /listShort="yisJ, S384, yisI, S383, S382" /listLong="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" promotor_-35 complement(1152144..1152153) /Source="Nicolas_upshift_promotors" /id="U865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1372 /SigmaFactorBS="aaatccctttttctcaattccgttttcatTTCGTTTCAGgac gggcttgctcTACATATCATACAAATGTCGttttgagaaggaggaaagaatatggagc g" /listShort="yisJ, S384, yisI, S383, S382" /listLong="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /label="promotor_-35" promotor_-35 1152173..1152181 /Source="Nicolas_upshift_promotors" /id="U866" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=553 /SigmaFactorBS="cccgtcctgaaacgaaatgaaaacggaattgagaaAAAGGGA TTtcagcattcgaCAGAGAATACATGAAGGAGcattctgatttaaaagatgatggagg a" /listShort="yisK, S386, yisL" /listLong="wprA" /label="promotor_-35" promotor_-10 1152193..1152211 /Source="Nicolas_upshift_promotors" /id="U866" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=553 /SigmaFactorBS="cccgtcctgaaacgaaatgaaaacggaattgagaaAAAGGGA TTtcagcattcgaCAGAGAATACATGAAGGAGcattctgatttaaaagatgatggagg a" /listShort="yisK, S386, yisL" /listLong="wprA" /label="promotor_-10" upshifts 1152198 /Source="Nicolas_upshifts" /id="U866" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=553 /SigmaFactorBS="cccgtcctgaaacgaaatgaaaacggaattgagaaAAAGGGA TTtcagcattcgaCAGAGAATACATGAAGGAGcattctgatttaaaagatgatggagg a" /listShort="yisK, S386, yisL" /listLong="wprA" CDS 1152244..1153149 /gene="mblK" /locus_tag="BSU_10750" /old_locus_tag="BSU10750" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16847875, 27215790, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16847875, 27215790, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydrolase/isomerase involved in remodelling the bacterial envelope" /protein_id="NP_388956.1" /db_xref="EnsemblGenomes-Gn:BSU10750" /db_xref="EnsemblGenomes-Tr:CAB12915" /db_xref="GOA:O06724" /db_xref="InterPro:IPR011234" /db_xref="InterPro:IPR036663" /db_xref="SubtiList:BG13098" /db_xref="UniProtKB/Swiss-Prot:O06724" /translation="MKFATGELYNRMFVGLIIDDEKIMDLQKAEKKLFELETIPGSLI ECIAEGDKFVAHARQLAEWAKKPNDELGSFMYSLSEVKLHAPIPKPSKNIICIGKNYR DHAIEMGSEADIPEHPMVFTKSPVTVTGHGDIVKSHEEVTSQLDYEGELAVVIGKSGT RISKEDAYDHVFGYTIVNDITARDLQKRHKQFFIGKSLDTTCPMGPVLVHKSSIQEPE RLKVETRVNGELRQSGSASDMIFSIPELIETLSKGMTLEAGDIIATGTPSGVGKGFTP PKFLRSGDKIDITIDPIGTLSNQIG*" gene 1152244..1153149 /gene="mblK" /locus_tag="BSU_10750" /old_locus_tag="BSU10750" S_feature 1153150..1153230 /Source="Nicolas_S_feature" /locus_tag="new_1153150_1153230" /HighExp="S2, Lbstat, S1, Etha, SMMPr, M0t90, M40t90, LoTm, T-4.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S386" promotor_-35 1153200..1153203 /Source="Nicolas_upshift_promotors" /id="U867" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=2462 /SigmaFactorBS="gacccgcccgttttttctgataatcatcTTTGtgacagagga caagttCATGGTACTATAAGTGGGGTaatttatctgatagggggaacatatatgacac a" /listShort="yisL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1153220..1153239 /Source="Nicolas_upshift_promotors" /id="U867" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=2462 /SigmaFactorBS="gacccgcccgttttttctgataatcatcTTTGtgacagagga caagttCATGGTACTATAAGTGGGGTaatttatctgatagggggaacatatatgacac a" /listShort="yisL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1153232 /Source="Nicolas_upshifts" /id="U867" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=2462 /SigmaFactorBS="gacccgcccgttttttctgataatcatcTTTGtgacagagga caagttCATGGTACTATAAGTGGGGTaatttatctgatagggggaacatatatgacac a" /listShort="yisL" /GFF_Attribute="listLong" CDS 1153265..1153621 /gene="yisL" /locus_tag="BSU_10760" /old_locus_tag="BSU10760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27215790; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388957.1" /db_xref="EnsemblGenomes-Gn:BSU10760" /db_xref="EnsemblGenomes-Tr:CAB12916" /db_xref="GOA:O06725" /db_xref="InterPro:IPR010899" /db_xref="SubtiList:BG13099" /db_xref="UniProtKB/Swiss-Prot:O06725" /translation="MTHLHITTWVVALILLFVSYSLYSSGSAKGAKITHMILRLFYIL IILTGAELFVRFANWNGEYAGKMILGIITIGLMEMLLIRKKKEKSTGGLWVGFVIVLL LTVLLGLHLPIGFQLF*" gene 1153265..1153621 /gene="yisL" /locus_tag="BSU_10760" /old_locus_tag="BSU10760" downshifts 1153518 /Source="Nicolas_upshifts" /id="D583" /incds=1 /nref=1 /ntot=44 /MaxReadThrough="4.28837" /MaxDrop="2.46999" /score="41.4247437" /energy="-11.7" /TU="U866,U867" /idTUdmin="U867" /TUdmin="-88" /isTUend="FALSE" downshifts 1153609 /Source="Nicolas_upshifts" /id="D584" /incds=0 /nref=17 /ntot=162 /MaxReadThrough="3.06092" /MaxDrop="3.41506" /score="41.4247437" /energy="-11.7" /TU="U866" /idTUdmin="U867" /TUdmin=3 /isTUend="TRUE" upshifts 1153742 /Source="Nicolas_upshifts" /id="U868" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.486513486513487" /psig="0.732267732267732" /xcortree=2782 /SigmaFactorBS="atattccaaatcatttaaaataaccttaaaattccctgtaag cggtatctcgtcctatgaaatTATGATACCTTCAAGGAGATtcattattttgcaggag g" /listShort="wprA" /GFF_Attribute="listLong" misc_feature 1153745..1153764 /Source="Nicolas_upshift_promotors" /id="U868" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.486513486513487" /psig="0.732267732267732" /xcortree=2782 /SigmaFactorBS="atattccaaatcatttaaaataaccttaaaattccctgtaag cggtatctcgtcctatgaaatTATGATACCTTCAAGGAGATtcattattttgcaggag g" /listShort="wprA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1153789..1156473 /gene="wprA" /locus_tag="BSU_10770" /old_locus_tag="BSU10770" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9004506, 9675284, 10336490, 15205417, 17269748, 21636651, 23180473, 25313396" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9004506, 9675284, 10336490, 15205417, 17269748, 21636651, 23180473, 25313396; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall-associated protease" /protein_id="NP_388958.1" /db_xref="EnsemblGenomes-Gn:BSU10770" /db_xref="EnsemblGenomes-Tr:CAB12917" /db_xref="GOA:P54423" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034084" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG11846" /db_xref="UniProtKB/Swiss-Prot:P54423" /translation="MKRRKFSSVVAAVLIFALIFSLFSPGTKAAAAGAIDQAAALENG KEQTGAMKEPEQVKWYKVTPGATDIQKNSHMALTVKSDSVLNVSVYPSKEKALKDETF EMYRSFTAEDGKSEVIFPYAWSGPYYVKVEYLGEEEPEDGGTAEAAAEAKYTIGYKGT KKQPSDLEEEEACPVEMSVDQKKSGKGILDKLRSIRDEQLSQTAEGKELTSLYYKAAP FIVAKLALNKTARNEIYQDLVTLKPLFDDVSENGASSSYKVTEKDQKAINRLYDKALQ SVPSFLKEEIKKQADRLNMKQLQGKTAGAILTENNIAAKSEVQTTKVIFKVKDNKSLS SVHNEMKGFSASAQSKKDISNVKKAKKLFDNLYSFELPKDEKQNGAYTASAKRVKSAA ATLSKMSNVEFAEPVQEYKSLANDIQYPYQWPLKNNGENGGVKNADVKYEPANTLLSK RKLNDTLIAVVDTGVDSTLADLKGKVRTDLGHNFVGRNNNAMDDQGHGTHVAGIIAAQ SDNGYSMTGLNAKAKIIPVKVLDSAGSGDTEQIALGIKYAADKGAKVINLSLGGGYSR VLEFALKYAADKNVLIAAASGNDGENALSYPASSKYVMSVGATNRMDMTADFSNYGKG LDISAPGSDIPSLVPNGNVTYMSGTSMATPYAAAAAGLLFAQNPKLKRTEVEDMLKKT ADDISFESVDGGEEELYDDYGDPIEIPKTPGVDWHSGYGRLNVMKAVSAADLQLKVNK LESTQTAVRGSAKEGTLIEVMNGKKKLGSAKAGKDNAFKVNIATQKQDQVLYLKATKG DAKTSYKVVVVKGKPSGTPKVNAVKTKDTAVKGKANSKAMIRVKNKSKKVIASAKADA KGTFSVKIKKQKAGTVLYVTAVDTDKKESKEAKVVVEK*" gene 1153789..1156473 /gene="wprA" /locus_tag="BSU_10770" /old_locus_tag="BSU10770" downshifts complement(1153957) /Source="Nicolas_upshifts" /id="D585" /incds=1 /nref=2 /ntot=155 /MaxReadThrough="0.14981" /MaxDrop="3.98572" /score="9.01750245" /energy="-8" /TU="NA" /idTUdmin="U869" /TUdmin=2563 /isTUend="FALSE" downshifts 1156465 /Source="Nicolas_upshifts" /id="D586" /incds=0 /nref=239 /ntot=267 /MaxReadThrough="1.55031" /MaxDrop="8.31576" /score="36.3638154" /energy="-12.3" /TU="NA" /idTUdmin="U868" /TUdmin="-1" /isTUend="TRUE" CDS complement(1156504..1157091) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388959.1" /db_xref="EnsemblGenomes-Gn:BSU10780" /db_xref="EnsemblGenomes-Tr:CAB12918" /db_xref="InterPro:IPR024488" /db_xref="SubtiList:BG12239" /db_xref="UniProtKB/Swiss-Prot:O06727" /translation="MKKKETAWMKRKQLLYTEERKWEYGTILIEDGICLIENGEGDIL LADSLQHSPIWIHHKGKWEQAGFQDKLVLACGAENISLSGGERIRYEKSVKRPLMALL DSLDDETFLAFLQHLHSFGLSVFDCVFSYNKGVFSNTSAGQGVSFYHFSNDTAQCAMQ HHYNYSSEGTGDRFEWTASNGKRSIMYTAVQRGRK*" gene complement(1156504..1157091) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" promotor_-10 complement(1157106..1157125) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1157125) /Source="Nicolas_upshifts" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" promotor_-35 complement(1157141..1157143) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1157146..1157152 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1157164 /Source="Nicolas_upshifts" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" promotor_-10 1157167..1157185 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1157170..1157236 /Source="Nicolas_S_feature" /locus_tag="new_1157170_1157236" /HighExp="S6, S5, S7, S8, B36, S4, BT, G/S, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S387" CDS 1157237..1159081 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" /EC_number="6.3.5.4" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (sporulation related)" /protein_id="NP_388960.2" /db_xref="EnsemblGenomes-Gn:BSU10790" /db_xref="EnsemblGenomes-Tr:CAB12919" /db_xref="GOA:O05272" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG12240" /db_xref="UniProtKB/Swiss-Prot:O05272" /translation="MCGITGWVDFKKQLVQEKQTMDRMTDTLSKRGPDDSNVWGEHHV LFGHKRLAVVDIEGGRQPMACTYKGDTYTIIYNGELYNTEDLRKELRARGHQFERTSD TEVLLHSYIEWQEDCVDHLNGIFAFAVWDEKRNLLFAARDRLGVKPFFYTKEGSSFLF GSEIKAILAHPDIKARVDRTGLSEIFGLGPSRTPGTGIFKGIKEIRPAHALTFSKDGL NIWRYWNVESEKHTDSFDDTVANVRSLFQDAVTRQLVSDVPVCTFLSGGLDSSAITAI AAGHFEKEGKAPLHTYSIDYEENDKYFQASAFQPNDDGPWIEKMTEAFGTTHHKCVIS QKDLVDHLEEAVLVKDLPGMADVDSSLLWFCREIKKDFVVSLSGECADEIFGGYPWFH TADVESGFPWMRSTEERIKLLSDSWQKKLNLKEYVNAKYEETLAETPLLDGETGVDKA RRQLFYLNMLWFMTNLLDRKDRMSMGASLEVRVPFADHRLVEYVWNIPWEMKMHDNRE KGILRKALEGILPDDILYRKKSPYPKTHHPEYTKGVSEWLKTIRSQKDSVLHTLLDRK QLDQLLETEGSSFKVPWFGQLMKGPQLIAHLAQIHTWFEAYRIDIDER*" gene 1157237..1159081 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" S_feature 1159082..1159149 /Source="Nicolas_S_feature" /locus_tag="new_1159082_1159149" /HighExp="S6, S5, S7, B36, BT, S8, S4, B60, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S388" downshifts 1159106 /Source="Nicolas_upshifts" /id="D587" /incds=0 /nref=12 /ntot=43 /MaxReadThrough="3.29969" /MaxDrop="4.67478" /score="3.55879494" /energy="-14.8" /TU="U870" /idTUdmin="U870" /TUdmin="-550" /isTUend="FALSE" CDS complement(1159211..1159690) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation related)" /protein_id="YP_054576.1" /db_xref="EnsemblGenomes-Gn:BSU10800" /db_xref="EnsemblGenomes-Tr:CAE01451" /db_xref="GOA:Q7WY73" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="PDB:2QE9" /db_xref="SubtiList:BG14187" /db_xref="UniProtKB/Swiss-Prot:Q7WY73" /translation="MMKFFEYNWQVRDQWFTWCHQLTTEELLKNRLGGVENILYTLFH IIDVEYSWIRAIQGKEDIAVQFADYQTLNKVKSLSNTFRTEIIDVLQTHSDQIKDELV SVPWETGVLYTRDEILHHIIAHEIHHIGQLSVWARELKLSPVSASFIGRTLKPIHSY* " gene complement(1159211..1159690) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" upshifts complement(1159710) /Source="Nicolas_upshifts" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" promotor_-10 complement(1159714..1159732) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1159743..1159751) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1159882..1159886 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1159899 /Source="Nicolas_upshifts" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" promotor_-10 1159901..1159920 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1159922..1160746 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" /EC_number="3.6.1.27" /experiment="publication(s) with functional evidences, PMID:23295493, 25308276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23295493, 25308276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate phosphatase" /protein_id="NP_388961.1" /db_xref="EnsemblGenomes-Gn:BSU10810" /db_xref="EnsemblGenomes-Tr:CAB12920" /db_xref="GOA:O06728" /db_xref="InterPro:IPR002060" /db_xref="InterPro:IPR008949" /db_xref="PDB:3WE9" /db_xref="SubtiList:BG12241" /db_xref="UniProtKB/Swiss-Prot:O06728" /translation="MIHRSEKMKEIKEAYQQCGQIVGEYAPACFKALSYLPLKQRQAS WAVLSFCHTAASADEKVLPAFEAKADHVYQRTNNGKQHLWKAFDHAYRTFTLESEPFR EFIAAQKEDAKPYDDLDELLMYAYRTGGAAGLMLLPILTRRKQDQLKQAAVSLGLAIQ LVRFLSDLGTDQQKNRIPRQVMQQFGYTEADLQKGTVNKAFTMTWEYIAFEAEAYLEE CQDALPLFPQYSQKTVKAALHLHRAVLEKIRAKQHDVFQYHFALTETEVKQILSDI*" gene 1159922..1160746 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" promotor_-35 1160134..1160140 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1160155..1160173 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1160162 /Source="Nicolas_upshifts" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature 1160756..1162206 /Source="Nicolas_S_feature" /locus_tag="new_1160756_1162206" /HighExp="Salt, Etha, Sw, Cold, G150, G180, G135, LBGtran, Heat, Paraq" /AntisenseName="yisQ" /AntisenseCor="0.19511630802652" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S389" CDS complement(1160776..1162143) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na(+)-driven efflux transporter" /protein_id="NP_388962.1" /db_xref="EnsemblGenomes-Gn:BSU10820" /db_xref="EnsemblGenomes-Tr:CAB12921" /db_xref="GOA:O07940" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG12242" /db_xref="UniProtKB/Swiss-Prot:O07940" /translation="MKQAVFKSTALKKPADKTFSLFSLTWPIFIEVSLYMFMGNADTL MLSQYSDNSVAAVGVSNQILNLIIVMFSFIATGTTVIISQFLGSRQKKEAMEVAYVSI GANFFISLAISAVVFFAAVPLLHMMGLSDALMPDAKVFLQVVGGLSFIQALIMTFSAI LKSYGYTKDTMFVTIGMNILNIAGNFVVIFGLFGFPVLGVAGVAMSTSIARVIGLIAM IVIVNKRIQLKMSLKKVFHMHKEHLRKLLKIGIPSAGEQLSYNLSQMIVTYFIAIMGA QALTTKVYTQNITMFILLFGTAISQGTQILIGRYIGGKQFDAAYERCMKSLYWALGIA AATSVLMTIFSKDLIGLFTQSPDIIATASLLIAMTIILEPGRSFNVIIINSLRAAGDA KFPVYMAMISMWGIGLPLAYLFGIHLGFGLAGIWISFIADEWVRGILMYRRWRSRIWI QKGMA*" gene complement(1160776..1162143) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" promotor_-35 1162175..1162182 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1162196..1162215 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1162208 /Source="Nicolas_upshifts" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" CDS 1162267..1163130 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388963.1" /db_xref="EnsemblGenomes-Gn:BSU10830" /db_xref="EnsemblGenomes-Tr:CAB12922" /db_xref="GOA:P40331" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11064" /db_xref="UniProtKB/Swiss-Prot:P40331" /translation="MPRILFTVPPFPVFIAAGEGVFKKGETHVKRVFSVFDLIYVKQG TLYITENETSFSVEGGEYILLSPGLEHYGTKGSDEATSYYWLHFDEHRYEFTAKGGSN WSELQQEKGSFEELARYGLALPRKGKVQRPQFMAQQFEKLIDYSAENSDLPLRKQILF EELMLHLQKEAFQIPSAKERVAWEAARYLQEHYKEKTTIKDLSLALHYHQDYVSRCMQ QVLGVTPAQYTNRVRMTEAKRLLSSTNDKMGVIAETVGMEDPTYFSKLFKQIEGISPI EYRKIVSRKVQ*" gene 1162267..1163130 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" CDS 1163148..1164161 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8407808, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8407808, 23504016, 28693424; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of iolX (LacI family)" /protein_id="NP_388964.1" /db_xref="EnsemblGenomes-Gn:BSU10840" /db_xref="EnsemblGenomes-Tr:CAB12923" /db_xref="GOA:P37947" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10847" /db_xref="UniProtKB/Swiss-Prot:P37947" /translation="MKTTIYDVAKAAGVSITTVSRVINNTGRISDKTRQKVMNVMNEM AYTPNVHAAALTGKRTNMIALVAPDISNPFYGELAKSIEERADELGFQMLICSTDYDP KKETKYFSVLKQKKVDGIIFATGIESHDSMSALEEIASEQIPIAMISQDKPLLPMDIV VIDDVRGGYEAAKHLLSLGHTNIACIIGDGSTTGEKNRIKGFRQAMEEAGVPIDESLI IQTRFSLESGKEEAGKLLDRNAPTAIFAFNDVLACAAIQAARIRGIKVPDDLSIIGFD NTILAEMAAPPLTTVAQPIKEMGRSVIELLAEAIEGKRKAKQKIVLPPELVVRHSTSP LNT*" gene 1163148..1164161 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" downshifts 1164144 /Source="Nicolas_upshifts" /id="D588" /incds=0 /nref=13 /ntot=204 /MaxReadThrough="0.51227" /MaxDrop="3.29173" /score="25.1260914" /energy="-9.6" /TU="NA" /idTUdmin="U874" /TUdmin=22 /isTUend="TRUE" promotor_-35 1164213..1164220 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1164235..1164254 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1164254..1164369 /Source="Nicolas_S_feature" /locus_tag="new_1164254_1164369" /HighExp="Lbstat, M40t90, M0t90, BI, G150, dia0, Mt0, Lbexp, Lbtran, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S390" upshifts 1164254 /Source="Nicolas_upshifts" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" CDS 1164370..1165398 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" /EC_number="1.1.1.370" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11160890, 20133360, 23109554, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 20133360, 23109554, 23504016, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NAD(+))" /protein_id="NP_388965.1" /db_xref="EnsemblGenomes-Gn:BSU10850" /db_xref="EnsemblGenomes-Tr:CAB12924" /db_xref="GOA:P40332" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11065" /db_xref="UniProtKB/Swiss-Prot:P40332" /translation="MEHQVRCAVLGLGRLGYYHAKNLVTSVPGAKLVCVGDPLKGRAE QVARELGIEKWSEDPYEVLEDPGIDAVIIVTPTSTHGDMIIKAAENGKQIFVEKPLTL SLEESKAASEKVKETGVICQVGFMRRFDPAYADAKRRIDAGEIGKPIYYKGFTRDQGA PPAEFIKHSGGIFIDCSIHDYDIARYLLGAEITSVSGHGRILNNPFMEQYGDVDQALT YIEFDSGAAGDVEASRTSPYGHDIRAEVIGTEGSIFIGTLRHQHVTILSAKGSSFDII PDFQTRFHEAYCLELQHFAECVRNGKTPIVTDIDATINLEVGIAATNSFRNGMPVQLD VKRAYTGM*" gene 1164370..1165398 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" downshifts 1165420 /Source="Nicolas_upshifts" /id="D589" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="0.33001" /MaxDrop="3.45406" /score="8.69111487" /energy="-13.4" /TU="NA" /idTUdmin="U875" /TUdmin=0 /isTUend="TRUE" CDS complement(1165449..1165958) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25651892; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative enzyme regulator of activity" /protein_id="NP_388966.2" /db_xref="EnsemblGenomes-Gn:BSU10860" /db_xref="EnsemblGenomes-Tr:CAB12925" /db_xref="GOA:O07939" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG12243" /db_xref="UniProtKB/Swiss-Prot:O07939" /translation="MTDAKQFYDYHSWANKKIFTHIENLPEETAYQEVKSVFPSVSDV LLHMCRADYIWLNVLSGVAYQEIIDSAGKLQSAQGNMAAIKQHAAELESQYHDFFSRQ TDLEQTFTMQHPKLGTLESTYADTILHVVNHGTYHRGNVTAMLRQLDHSGVPTDYMYY LYEKRESKG*" gene complement(1165449..1165958) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" downshifts complement(1165468) /Source="Nicolas_upshifts" /id="D590" /incds=0 /nref=81 /ntot=251 /MaxReadThrough="-0.0416600000000003" /MaxDrop="7.15629" /score="27.2292301" /energy="-13.4" /TU="NA" /idTUdmin="U876" /TUdmin="-16" /isTUend="TRUE" promotor_-10 complement(1165971..1165989) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1165987) /Source="Nicolas_upshifts" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" promotor_-35 complement(1166001..1166009) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1166008..1166670) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid related metabolite efflux transporter" /protein_id="NP_388967.1" /db_xref="EnsemblGenomes-Gn:BSU10870" /db_xref="EnsemblGenomes-Tr:CAB12926" /db_xref="GOA:O06730" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG13100" /db_xref="UniProtKB/Swiss-Prot:O06730" /translation="MTISLMIEKKCERSFFSMNAIIHGIVLAFGLILPLGVQNVFIFQ QGALQKHIWRALPAVISASVCDTLLIVLAVAGVSVIVQELPVFETVMMAGGFLFLLYM GWVTWNIRPNTSQNEKHTFTPKKQAAFAAAVSLLNPHAILDTIGVIGTSSLQYSGLEK WLFMAACIAVSWIWFISLAIAGRLFQTIDTSGRLMLIVNKCSAAVMWAAAGYFGVSLF CN*" gene complement(1166008..1166670) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" promotor_-35 1166689..1166695 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1166709..1166728 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1166718 /Source="Nicolas_upshifts" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" CDS 1166737..1168191 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 19383706; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388968.2" /db_xref="EnsemblGenomes-Gn:BSU10880" /db_xref="EnsemblGenomes-Tr:CAB12927" /db_xref="GOA:Q796Q6" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13101" /db_xref="UniProtKB/Swiss-Prot:Q796Q6" /translation="MTLSQWQPSRKSDVPLHRQIEQYMKDKILHGEWAVGTKIPSQRT LADMFQVNRSTVTAAIDELTSQGLLEGRKGGGTKVVNSTWSVLTAEPPLDWSDYVRSG IHRANSSIIQAINQNEPRADIIRLGTGELSPDLVPADTIGRMFQQINPGVLSLGYEQP KGNRQLREAVADHLKGKKIHVSPSAILIVSGALQALQLISIGLLKRDSVILTEKPSYL QSLHVFQSAGMRLRGLPMDDEGVKAGLVSSNRKQYGGQLLYTIPSFHNPTGTVMSEQR RKEIISLSKKEQMPIIEDDAYGDLWFEEKPPQPLKAMDHEGNILYLGAFSKTVSPGLR IGWLAGPEPVIERLADIKMQTDYGSSGLSQWAAAEWLSQGYYEEHLTWVRRKLKERRD AAVHFLERYAGDIATWRIPAGGFYIWVTFHKNLPVSRFFYELLKRQVLVNPGYIYDGE DRNSIRLSYSYASLGDLETGIKAAAETARRLMMS*" gene 1166737..1168191 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" S_feature complement(1168046..1168198) /Source="Nicolas_S_feature" /locus_tag="new_1168046_1168198_c" /HighExp="Diami, Sw, C90, LBGstat, dia15, Paraq, dia5, BC, M40t45, Oxctl" /AntisenseName="yisV" /AntisenseCor="0.69858995161852" /AntisenseRegPval="-40" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S391" downshifts complement(1168081) /Source="Nicolas_upshifts" /id="D591" /incds=1 /nref=2 /ntot=84 /MaxReadThrough="2.36735" /MaxDrop="2.81041" /score="-5.131548" /energy="-17.3" /TU="NA" /idTUdmin="U879" /TUdmin="-11" /isTUend="TRUE" CDS complement(1168199..1168837) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388970.1" /db_xref="EnsemblGenomes-Gn:BSU10890" /db_xref="EnsemblGenomes-Tr:CAB12929" /db_xref="InterPro:IPR001646" /db_xref="SubtiList:BG13103" /db_xref="UniProtKB/Swiss-Prot:O06733" /translation="MNKIAIQKPNIPENLQTADFHDAVTQDDVISMHLFEDCTICGED IERLCVEKTVFRNVVFIDVSFRHIELTDVIFEKCDLSNADFSGAVIHRTSVKQSKMVG MNVAEATLRNVSFEECHGHFSSFSYSNMKQVRFDHCALMQSECSDTVLQQTHFDGCEL EGASFTGTSLQNMDISTCRFEQLHVSLDKLKGCKIAPEHAIAFARALGAVIV*" gene complement(1168199..1168837) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" S_feature complement(1168838..1168972) /Source="Nicolas_S_feature" /locus_tag="new_1168838_1168972_c" /HighExp="Diami, dia15, dia5, C90, BC, Paraq, LBGstat, Lbtran, HiOs, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S392" promotor_-35 1168886..1168891 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1168907..1168925 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1168908 /Source="Nicolas_upshifts" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" S_feature 1168918..1169042 /Source="Nicolas_S_feature" /locus_tag="new_1168918_1169042" /HighExp="S6, S5, S8, S7, S4, BT, B36, S3, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S393" promotor_-10 complement(1168958..1168977) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1168972) /Source="Nicolas_upshifts" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" promotor_-35 complement(1168992..1168999) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1169043..1169849 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl hydrolase or peroxidase" /protein_id="NP_388971.1" /db_xref="EnsemblGenomes-Gn:BSU10900" /db_xref="EnsemblGenomes-Tr:CAB12930" /db_xref="GOA:O06734" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13104" /db_xref="UniProtKB/Swiss-Prot:O06734" /translation="MGHYIKTEEHVTLFVEDIGHGRPIIFLHGWPLNHKMFEYQMNEL PKRGFRFIGVDLRGYGQSDRPWEGYDYDTMADDVKAVIYTLQLENAILAGFSMGGAIA IRYMARHEGADVDKLILLSAAAPAFTKRPGYPYGMRKQDIDDMIELFKADRPKTLADL GKQFFEKKVSPELRQWFLNLMLEASSYGTIHSGIALRDEDLRKELAAIKVPTLILHGR KDRIAPFDFAKELKRGIKQSELVPFANSGHGAFYEEKEKINSLIAQFSNS*" gene 1169043..1169849 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" downshifts 1169842 /Source="Nicolas_upshifts" /id="D592" /incds=0 /nref=4 /ntot=24 /MaxReadThrough="2.64682" /MaxDrop="5.60718" /score="8.70914085" /energy="-6.5" /TU="NA" /idTUdmin="U878" /TUdmin=0 /isTUend="TRUE" CDS complement(1169877..1170476) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" /EC_number="2.7.1.25" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenylylsulfate kinase" /protein_id="NP_388972.1" /db_xref="EnsemblGenomes-Gn:BSU10910" /db_xref="EnsemblGenomes-Tr:CAB12931" /db_xref="GOA:O06735" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13105" /db_xref="UniProtKB/Swiss-Prot:O06735" /translation="MTHNPNIIWHPAAISKSDRQSLNGHKSCVLWFTGLSGSGKSVLA NAVDEKLYRKGIQSYVLDGDNIRHGLNKDLGFQTGDRIENIRRIGEVAKLFVDSGQMI LTAFISPFREDRDMVRALFPKGEFFEIYVKCPLHVCEQRDPKGLYKKARNGEIKHFTG IDSPYEAPLSPDFIIESDQTSISDGADLIINALQNRGII*" gene complement(1169877..1170476) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" downshifts complement(1169896) /Source="Nicolas_upshifts" /id="D593" /incds=0 /nref=35 /ntot=44 /MaxReadThrough="1.69999" /MaxDrop="6.8011" /score="17.1506785" /energy="-7.3" /TU="NA" /idTUdmin="U880" /TUdmin=0 /isTUend="TRUE" CDS complement(1170473..1171642) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" /EC_number="2.7.7.4" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfate adenylyltransferase" /protein_id="NP_388973.2" /db_xref="EnsemblGenomes-Gn:BSU10920" /db_xref="EnsemblGenomes-Tr:CAB12932" /db_xref="GOA:O06736" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13106" /db_xref="UniProtKB/Swiss-Prot:O06736" /translation="MNGNEPHGGVLINRCDPACHFEGCACQAELDQLALSDLELIAIG GYSPLTGFLGEKDYHSVVKEMRLANGLPWSLPITLPVGEKTARQLSAGDHVKLVKDGV TYGMITVTDIYQPDKTQEALSVFKTNDPAHPGVKKLLARPDYYIGGPITVSSLPDKSF EQFYATPAETRAAFQKLGWKTIVGFQTRNPVHRAHEYIQKTALETVDGLLLHPLVGET KSDDIPSDIRMESYQALLNHYYPKDRVMLSVFPAAMRYAGPREAIFHALVRKNYGCTH FIVGRDHAGVGSYYGTYDAQNIFQSFTEEELGIKPLFFEHSFYCRKCGNMGTSKTCPH SPRDHIHLSGTKVRELLRQGKKPPKEFSRPEVAAVLIKGLHQQPVAIKQNSGELQ*" gene complement(1170473..1171642) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" S_feature complement(1171643..1171754) /Source="Nicolas_S_feature" /locus_tag="new_1171643_1171754_c" /HighExp="S6, S7, S8, BT, S5, B36, G/S, Pyr, SMMPr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S394" CDS complement(1171755..1172465) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospho-adenylylsulfate reductase" /protein_id="NP_388974.2" /db_xref="EnsemblGenomes-Gn:BSU10930" /db_xref="EnsemblGenomes-Tr:CAB12933" /db_xref="GOA:O06737" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13107" /db_xref="UniProtKB/Swiss-Prot:O06737" /translation="MNETITYDTWNDMLSKQITDQLIDELDVLKWAYRTYGEKIVYAC SFGAEGMVLLDLISKINKNAHIIFLDTGLHFQETYELIETVKERYPGFAIQMLEPELS LTEQGTKYGGELWKHNPNLCCQLRKIEPLKKHLSGMTAWISGLRRDQSPTRKHIQYVN LDQKFELIKICPLIHWTWDDVWTYIRLHNLPYNKLHDQHYPSIGCEMCTLPSPDPNDE RAGRWAGREKTECGLHQE*" gene complement(1171755..1172465) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" promotor_-10 complement(1172509..1172528) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1172531) /Source="Nicolas_upshifts" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" promotor_-35 complement(1172541..1172550) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1172580..1172589 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1172603..1172622 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1172614 /Source="Nicolas_upshifts" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" CDS 1172650..1173336 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" /EC_number="3.1.3.71" /function="15.7: Sporulation and germination" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3346220, 11830598, 15383836, 16341843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho,3-sulfolactate phosphatase (sporulation related)" /protein_id="NP_388975.1" /db_xref="EnsemblGenomes-Gn:BSU10940" /db_xref="EnsemblGenomes-Tr:CAB12934" /db_xref="GOA:O06738" /db_xref="InterPro:IPR005238" /db_xref="InterPro:IPR036702" /db_xref="SubtiList:BG13108" /db_xref="UniProtKB/Swiss-Prot:O06738" /translation="MPIAIYQGHHHSLAPADINIVIDVIRAFTVAHYAFIGGAKEILL VRTADEAFALKDTYPDYVLTGEEKGVGISGFDLDNSPKRMAGQNMTDKSLIQKTTNGV TAALGALNAKHLFVTGFSNAKTTAQHVKKLVANDCVINIVASHPSGDDDMACAEYIKG IIEGTNVVTAAEAIERIKGSSVAEKFFDCRQPLFDSEDIVYCTKELTGDFVMKVKQDG EVPTIERVII*" gene 1172650..1173336 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" CDS 1173333..1174091 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" /EC_number="4.4.1.19" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11830598, 15014443, 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho-3-sulfolactate synthase" /protein_id="NP_388976.1" /db_xref="EnsemblGenomes-Gn:BSU10950" /db_xref="EnsemblGenomes-Tr:CAB12935" /db_xref="GOA:O06739" /db_xref="InterPro:IPR003830" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036112" /db_xref="PDB:1U83" /db_xref="SubtiList:BG13109" /db_xref="UniProtKB/Swiss-Prot:O06739" /translation="MNDFSLELPVRTNKPRETGQSILIDNGYPLQFFKDAIAGASDYI DFVKFGWGTSLLTKDLEEKISTLKEHDITFFFGGTLFEKYVSQKKVNEFHRYCTYFGC EYIEISNGTLPMTNKEKAAYIADFSDEFLVLSEVGSKDAELASRQSSEEWLEYIVEDM EAGAEKVITEARESGTGGICSSSGDVRFQIVDDIISSDIDINRLIFEAPNKTLQQGFI QKIGPNVNLANIPFHDAIALETLRLGLRSDTFFL*" gene 1173333..1174091 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" downshifts 1174088 /Source="Nicolas_upshifts" /id="D594" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="2.37654" /MaxDrop="4.17689" /score="-1.32868938" /energy="-17.6" /TU="NA" /idTUdmin="U881" /TUdmin=0 /isTUend="TRUE" CDS complement(1174136..1174765) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26335199; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388977.1" /db_xref="EnsemblGenomes-Gn:BSU10960" /db_xref="EnsemblGenomes-Tr:CAB12936" /db_xref="GOA:O06740" /db_xref="InterPro:IPR003740" /db_xref="SubtiList:BG13110" /db_xref="UniProtKB/Swiss-Prot:O06740" /translation="MAELLMKAKLTFMIVVGGVLQGLGMSLFLFPHDIPTGGAAGIAV LLHYLFQIPHGFSVWAVNVSMLFTALKWLEMRTFTGTLASITVTSVSVLIFDAVFPDI TSNLWLDLASGAVLLGLGIGLLYKYKISNGGFGALALMISIYRGGNPGTILLIMNCII FMVTASIIDWGIVIQALICQVISTRVIDFIYNIRLTSLPYLTPMYRHKK*" gene complement(1174136..1174765) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" promotor_-10 complement(1174799..1174817) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1174816) /Source="Nicolas_upshifts" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" promotor_-35 complement(1174832..1174837) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1174861..1175976) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 11747447, 27994575; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enolase superfamily enzyme (isomerase /dehydratase)" /protein_id="NP_388978.1" /db_xref="EnsemblGenomes-Gn:BSU10970" /db_xref="EnsemblGenomes-Tr:CAB12937" /db_xref="GOA:O06741" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR036849" /db_xref="PDB:2GDQ" /db_xref="PDB:2GGE" /db_xref="SubtiList:BG13111" /db_xref="UniProtKB/Swiss-Prot:O06741" /translation="MKIVRIETFPLFHRLEKPYGDANGFKRYRTCYLIRIITESGIDG WGECVDWLPALHVGFTKRIIPFLLGKQAGSRLSLVRTIQKWHQRAASAVSMALTEIAA KAADCSVCELWGGRYREEIPVYASFQSYSDSPQWISRSVSNVEAQLKKGFEQIKVKIG GTSFKEDVRHINALQHTAGSSITMILDANQSYDAAAAFKWERYFSEWTNIGWLEEPLP FDQPQDYAMLRSRLSVPVAGGENMKGPAQYVPLLSQRCLDIIQPDVMHVNGIDEFRDC LQLARYFGVRASAHAYDGSLSRLYALFAQACLPPWSKMKNDHIEPIEWDVMENPFTDL VSLQPSKGMVHIPKGKGIGTEINMEIVNRYKWDGSAY*" gene complement(1174861..1175976) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" downshifts complement(1174890) /Source="Nicolas_upshifts" /id="D595" /incds=0 /nref=11 /ntot=42 /MaxReadThrough="1.81817" /MaxDrop="4.27426" /score="13.5713023" /energy="-14.5" /TU="NA" /idTUdmin="U883" /TUdmin=0 /isTUend="TRUE" CDS complement(1175985..1177253) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 14762009, 15109717, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388979.1" /db_xref="EnsemblGenomes-Gn:BSU10980" /db_xref="EnsemblGenomes-Tr:CAB12938" /db_xref="GOA:Q796Q1" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13112" /db_xref="UniProtKB/Swiss-Prot:Q796Q1" /translation="MESSKQNNGMTIVAIGSIPLILTLGNSMLIPILPKMKSELHLSQ FQVSLVITVFSLIAAFAIPIVGYLADRFSRKVIIIPCLILYGAGGLLAGFAAGFFDNA YPWVMAGRALQGIGAAGTGPIAMALTGDLFKGAQESKVLGLVEASNGMGKVLSPIIGS LIALLVWYGAFFAFPVFCIISIVLTWIFIKEKKKEKEPPPIGQYAKGLLSVFKHEGRW LFTAYLAGATCLFTLFGILFYLSDVLEKTYDTDGVKKGLILAIPLLVMCVTSYTTGSK IGQKQSLMKKLIVLGLAFMTVSYAALSFIENLVLFISVLVLSSIGSGLVLPCVNSFIT GAVGKERRGFVTSLYGSVRFLGVAIGPPIFGRLMQWSRPGMFLSIAGLTLVVGILVMM LIHVKQNNEETKEKEDPKMAGNRLQPAEER*" gene complement(1175985..1177253) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" promotor_-10 complement(1177279..1177290) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1177288) /Source="Nicolas_upshifts" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" promotor_-35 complement(1177304..1177310) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1177365..1178213) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388980.1" /db_xref="EnsemblGenomes-Gn:BSU10990" /db_xref="EnsemblGenomes-Tr:CAB12939" /db_xref="GOA:O06743" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13113" /db_xref="UniProtKB/Swiss-Prot:O06743" /translation="MDVVDELIKLHEEHVSGLLRLCGQAGWPDYGEQELKLLVQQGRF FGYQNVSGDIISCIGLFLFGRLTSIGLVIVDKEYQRLGLGRRMVNACITQTDENTAIR LCATKEGLPLYEKAGFHTAGSVRKYSCHSFQPYTKKLDAELTSFREQDFHDLTAADLA AFGGDRSNLLQQLISASCECIIARNQDGQLIGYGLSVQTPANLKFGPIIAPSSDVAAQ IITRLAAGKQGPMRIDIPSEHTSLHDSLIEMGFHKDDEPPILFYQKKAPIQNGHLYAL ISQALG*" gene complement(1177365..1178213) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" downshifts complement(1177376) /Source="Nicolas_upshifts" /id="D596" /incds=0 /nref=34 /ntot=209 /MaxReadThrough="2.34135" /MaxDrop="3.51892" /score="14.8688564" /energy="-11.7" /TU="NA" /idTUdmin="U884" /TUdmin=0 /isTUend="TRUE" CDS complement(1178218..1178667) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388981.2" /db_xref="EnsemblGenomes-Gn:BSU11000" /db_xref="EnsemblGenomes-Tr:CAB12940" /db_xref="GOA:O06744" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13114" /db_xref="UniProtKB/Swiss-Prot:O06744" /translation="MLEVKTISVEDTYEIRHRILRPHQSIEQCKYKEDHAEGSFHLGV FYDGTLISIASFSPQSQPLLTEASAYRLRGMATLEGYRDQKAGSTLIKHAEHKLAESG VQAVWCNARHHVKGYYAKLGWKELGEPFDIPGIGNHIVMYKTLRTSR*" gene complement(1178218..1178667) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" promotor_-10 complement(1178688..1178707) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1178702) /Source="Nicolas_upshifts" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" promotor_-35 complement(1178723..1178724) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1178757..1180595) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" /EC_number="1.5.1.20" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 17264075, 20421295, 20951706, 26233166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional homocysteine S-methyltransferase using (R,S)AdoMet and methylenetetrahydrofolate reductase [NAD(P)H]" /protein_id="NP_388982.1" /db_xref="EnsemblGenomes-Gn:BSU11010" /db_xref="EnsemblGenomes-Tr:CAB12941" /db_xref="GOA:O06745" /db_xref="InterPro:IPR003171" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR029041" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG13115" /db_xref="UniProtKB/Swiss-Prot:O06745" /translation="MGLLEDLQRQVLIGDGAMGTLLYSYGIDRCFEELNISKPEEIQR IHKAYVEAGANIIQTNTYGANYIKLSRHGLEDDIKKMNQEAVKIARASAGDAYVLGTM GGIRTFNKNAYSLDEIKRSFREQLYLLLHEEPDGLLLETYYDLEEAREVLKIARKETD LPIMLNVSMHEQGVLQDGTPLSDALRSIADLGADIVGINCRLGPYHMIEALSEVPIFD DVFLSVYPNSSLPSLEEGRLVYETDDTYFQNSASEFRKQGARIIGGCCGTTPNHIRAM AEAVGGLAPITEKEVKTRAKEFISVHHERTEPGLDEIAAKKRSIIVELDPPKKLSFDK FLSAAAELKEAGIDALTLADNSLATPRISNVACGALVKQQLDMRSLVHITCRDRNIIG LQSHLMGLDTLGLNDVLAITGDPSKIGDFPGATSVYDLTSFDLIRLIKQFNEGLSLSG KPLGKKTNFSVAAAFNPNVRHLDKAVKRLEKKIDCGADYFVSQPVYSEQQLVDIHNET KHLKTPIYIGIMPLTSSRNAEFIHNEIPGIKLSDTIREKMAHAGEDKEKQKAEGLAIA RSLLDTACELFNGIYLITPFLRSDLTAELTSYIQQKDEQRQNIFLH*" gene complement(1178757..1180595) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" downshifts complement(1178784) /Source="Nicolas_upshifts" /id="D597" /incds=0 /nref=14 /ntot=91 /MaxReadThrough="3.04289" /MaxDrop="4.13744" /score="12.9586126" /energy="-16.2" /TU="U885" /idTUdmin="U885" /TUdmin="-66" /isTUend="FALSE" downshifts complement(1180677) /Source="Nicolas_upshifts" /id="D598" /incds=0 /nref=47 /ntot=128 /MaxReadThrough="8.00128" /MaxDrop="5.61487" /score="22.3754155" /energy="-7.3" /TU="U885,U887" /idTUdmin="U887" /TUdmin="-1079" /isTUend="FALSE" misc_RNA complement(1180685..1180802) /gene="mswK" /locus_tag="BSU_misc_RNA_12" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" gene complement(1180685..1180802) /gene="mswK" /locus_tag="BSU_misc_RNA_12" promotor_-10 complement(1180854..1180873) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" upshifts complement(1180868) /Source="Nicolas_upshifts" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" promotor_-35 complement(1180888..1180895) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS complement(1180909..1181400) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12943362, 25329577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA or cyclic d-GMP binding protein" /protein_id="NP_388983.1" /db_xref="EnsemblGenomes-Gn:BSU11020" /db_xref="EnsemblGenomes-Tr:CAB12942" /db_xref="InterPro:IPR007551" /db_xref="InterPro:IPR035570" /db_xref="InterPro:IPR035571" /db_xref="InterPro:IPR036183" /db_xref="SubtiList:BG13116" /db_xref="UniProtKB/Swiss-Prot:O06746" /translation="MAKESSFDIVSKVELPEVQNAIQIALKEISTRYDFKGSKSDISL DKEELVLVSDDEFKLSQLKDVLVSKLIKRNVPTKNIDYGKVENASGGTVRQRAKLVQG IDKDNAKKINTIIKNSGLKVKSQVQDDQVRVTGKNKDDLQQIISAVRGADLPIDVQFI NFR*" gene complement(1180909..1181400) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" promotor_-35 1181418..1181421 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1181424..1181443) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" promotor_-10 1181436..1181455 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1181437 /Source="Nicolas_upshifts" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" upshifts complement(1181442) /Source="Nicolas_upshifts" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" promotor_-35 complement(1181458..1181465) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS 1181499..1182395 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20399190; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA-binding protein" /protein_id="NP_388984.1" /db_xref="EnsemblGenomes-Gn:BSU11030" /db_xref="EnsemblGenomes-Tr:CAB12943" /db_xref="GOA:O06747" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014464" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13117" /db_xref="UniProtKB/Swiss-Prot:O06747" /translation="MLTKSAENKRNRKDDSMRPGQQLTLSIDHQTDFGYFLTDGEDTI LLHNSEMTEDIEDRDEVEVFIYVDQQERLAATMKIPIISADEYGWVEVVDKVEDMGVF VDVGLSKDALVATEHLPPYEDVWPQKGDKLYCMLKVTNRGRMFAKPAPEDIISELFTD ASEDLMNKELTGTVYRLIASGSFVITDDGIRCFIHPSERKEEPRLGSRVTGRVIQVKE DGSVNLSLLPRKQDAMSVDAECILTYMRMRNGAMPYSDKSQPDDIRERFNMSKAAFKR ALGHLMKNGKVYQENGWTYEKK*" gene 1181499..1182395 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" downshifts 1182382 /Source="Nicolas_upshifts" /id="D599" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="1.78082" /MaxDrop="6.73614" /score="40.361011" /energy="-21.5" /TU="NA" /idTUdmin="U886" /TUdmin=0 /isTUend="TRUE" CDS complement(1182448..1183032) /gene="yitM" /locus_tag="BSU_11040" /old_locus_tag="BSU11040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11557812" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388985.1" /db_xref="EnsemblGenomes-Gn:BSU11040" /db_xref="EnsemblGenomes-Tr:CAB12944" /db_xref="GOA:O06748" /db_xref="InterPro:IPR023888" /db_xref="SubtiList:BG13118" /db_xref="UniProtKB/Swiss-Prot:O06748" /translation="MKKAFLVFLSVVLVTTVFLVKQQESVAQAKQLEYSGEEIFKGFV FAQGEVGKQLPEVFNKAMTDKLNTKQAKAFANQVVADIKKEDADFFDNLKKAVYSKDA LKVDELLKKAGQIVEEKVEAAKEIAASKDDTSRVQAELVNTVDTANYFYYVSYVAAAG ALILIILAIDITPIAISDNVDREMAIRTLVDELN*" gene complement(1182448..1183032) /gene="yitM" /locus_tag="BSU_11040" /old_locus_tag="BSU11040" downshifts complement(1182458) /Source="Nicolas_upshifts" /id="D600" /incds=0 /nref=68 /ntot=158 /MaxReadThrough="1.3386" /MaxDrop="7.40935" /score="10.143892" /energy="-21.5" /TU="NA" /idTUdmin="U888" /TUdmin=0 /isTUend="TRUE" CDS complement(1183029..1183958) /gene="yitO" /locus_tag="BSU_11055" /old_locus_tag="BSU11055" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11557812, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein with HTTM domain" /protein_id="NP_388987.2" /db_xref="EnsemblGenomes-Gn:BSU11055" /db_xref="EnsemblGenomes-Tr:CAB12946" /db_xref="GOA:O06750" /db_xref="InterPro:IPR011020" /db_xref="InterPro:IPR023894" /db_xref="SubtiList:BG13120" /db_xref="UniProtKB/Swiss-Prot:O06750" /translation="MLENIKQTITRWDERNPWTNVYGLARSIIALSSLLTLLINHPSL IMKPASGISSYPACKMNLSLFCLGENNYMMLNLFRWVCIAILVLVVIGWRPRITGVLH WYVSYSLQSSLIVIDGGEQAAAVMTFLLLPITLTDPRKWHWSTRPIEGKRTLGKITAF ISYFVIRIQVAVLYFHSTVAKLSQQEWVDGTAVYYFAQEKTIGFNGFFQALTKPIVTS PFVVIPTWGTLLVQIVIFAALFAPKKHWRLILIIAVFMHEIFAVMLGLISFSIIMAGI LILYLTPIDSTIQFTYIRRLLWNKKHKKGEVSV*" gene complement(1183029..1183958) /gene="yitO" /locus_tag="BSU_11055" /old_locus_tag="BSU11055" misc_feature complement(1183114) /Source="Nicolas_upshift_promotors" /id="U888" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.232767232767233" /psig="0.63936063936064" /xcortree=2974 /SigmaFactorBS="agtcatgctgggcctcatcagtttttcgattatcatggccgg cattttgatattgtatctcaCtcctatcgattccacgattcaatttacatatattcgc a" /listShort="yitM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1183116) /Source="Nicolas_upshifts" /id="U888" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.232767232767233" /psig="0.63936063936064" /xcortree=2974 /SigmaFactorBS="agtcatgctgggcctcatcagtttttcgattatcatggccgg cattttgatattgtatctcaCtcctatcgattccacgattcaatttacatatattcgc a" /listShort="yitM" /GFF_Attribute="listLong" CDS complement(1183943..1184479) /gene="yitP" /locus_tag="BSU_11070" /old_locus_tag="BSU11070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 6289325, 11557812" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388988.1" /db_xref="EnsemblGenomes-Gn:BSU11070" /db_xref="EnsemblGenomes-Tr:CAB12947" /db_xref="GOA:O06751" /db_xref="InterPro:IPR023902" /db_xref="SubtiList:BG13121" /db_xref="UniProtKB/Swiss-Prot:O06751" /translation="MQKSISFFVIFSILWGSLFLFSIIGSLGTTPIPLTKDSKFLMSS ILPQGWGFFSKNPRDTAIGLYEAENASAKVRWPNMRADNLFGLYRYGRSQGVEMGVIY SQVGKEQWTACKEKDLGACKSKAKTVQLKTPAPRPLLCGSYYLTKEDIVPWSYSKYTP SSYQVKSIVKVVISCSKT*" gene complement(1183943..1184479) /gene="yitP" /locus_tag="BSU_11070" /old_locus_tag="BSU11070" promotor_-10 complement(1184515..1184534) /Source="Nicolas_upshift_promotors" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1184529) /Source="Nicolas_upshifts" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" promotor_-35 complement(1184549..1184552) /Source="Nicolas_upshift_promotors" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1184620..1184627 /Source="Nicolas_upshift_promotors" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1184642..1184661 /Source="Nicolas_upshift_promotors" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1184645 /Source="Nicolas_upshifts" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" CDS 1184657..1185004 /gene="yizB" /locus_tag="BSU_11079" /old_locus_tag="BSU11079" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="YP_003097701.1" /db_xref="EnsemblGenomes-Gn:BSU11079" /db_xref="EnsemblGenomes-Tr:CAX52589" /db_xref="GOA:C0H3Y4" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3Y4" /translation="MKTNQVNDRWIVQFRKGIFELAILSLLRSKPMYGYELTSSLKTT SALAISEGAIYPILKRMTEKGWIEFFWEDSLDGPKRKYYKMTQKGEEMLKERLEKYLE THQALLSLSGDLL*" gene 1184657..1185004 /gene="yizB" /locus_tag="BSU_11079" /old_locus_tag="BSU11079" CDS 1185001..1185588 /gene="yitQ" /locus_tag="BSU_11080" /old_locus_tag="BSU11080" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23504016" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388989.2" /db_xref="EnsemblGenomes-Gn:BSU11080" /db_xref="EnsemblGenomes-Tr:CAB12948" /db_xref="GOA:O06752" /db_xref="SubtiList:BG13122" /db_xref="UniProtKB/Swiss-Prot:O06752" /translation="MNGQLIIDRYMEELNAELANMPDVERENAIDELKGHITAFVQDR IKAGLSEEELQEAVESEFSHPKELAELMMGDGGETKRRRSLLGKSWISVLLIVTIIAL PLLPSDFRHLPLAVYLMVLAGYVWKRKKLVMFAGVRKNKMRSQKEIVKISRVGAVYLL FLAVVLLLSPFLNALVVLLLIAVSCAAFFLFLNIK*" gene 1185001..1185588 /gene="yitQ" /locus_tag="BSU_11080" /old_locus_tag="BSU11080" CDS 1185608..1185901 /gene="yitR" /locus_tag="BSU_11090" /old_locus_tag="BSU11090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388990.1" /db_xref="EnsemblGenomes-Gn:BSU11090" /db_xref="EnsemblGenomes-Tr:CAB12949" /db_xref="GOA:O06753" /db_xref="InterPro:IPR017259" /db_xref="SubtiList:BG13123" /db_xref="UniProtKB/Swiss-Prot:O06753" /translation="MEISINYLLIVIALLFFVVAYFVGIKKQTWMLAGFNEARIRDKD RLARIAGYFFLNSGLFILLNSFISFQGQEQLIPPLILAYGAGVIIYVNKKLVE*" gene 1185608..1185901 /gene="yitR" /locus_tag="BSU_11090" /old_locus_tag="BSU11090" downshifts 1185881 /Source="Nicolas_upshifts" /id="D601" /incds=0 /nref=119 /ntot=240 /MaxReadThrough="1.96008" /MaxDrop="5.72545" /score="2.11183863" /energy="-12.6" /TU="NA" /idTUdmin="U890" /TUdmin=0 /isTUend="TRUE" downshifts 1185925 /Source="Nicolas_upshifts" /id="D602" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="0.34732" /MaxDrop="3.0285" /score="2.11183863" /energy="-12.6" /TU="NA" /idTUdmin="U890" /TUdmin=44 /isTUend="FALSE" CDS 1186037..1187653 /gene="nprB" /locus_tag="BSU_11100" /old_locus_tag="BSU11100" /EC_number="3.4.24.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1917867, 16672610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1917867, 16672610; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular neutral protease B" /protein_id="NP_388991.1" /db_xref="EnsemblGenomes-Gn:BSU11100" /db_xref="EnsemblGenomes-Tr:CAB12950" /db_xref="GOA:P39899" /db_xref="InterPro:IPR001570" /db_xref="InterPro:IPR011096" /db_xref="InterPro:IPR013856" /db_xref="InterPro:IPR023612" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG10691" /db_xref="UniProtKB/Swiss-Prot:P39899" /translation="MRNLTKTSLLLAGLCTAAQMVFVTHASAEESIEYDHTYQTPSYI IEKSPQKPVQNTTQKESLFSYLDKHQTQFKLKGNANSHFRVSKTIKDPKTKQTFFKLT EVYKGIPIYGFEQAVAMKENKQVKSFFGKVHPQIKDVSVTPSISEKKAIHTARRELEA SIGKIEYLDGEPKGELYIYPHDGEYDLAYLVRLSTSEPEPGYWHYFIDAKNGKVIESF NAIHEAAGTGIGVSGDEKSFDVTEQNGRFYLADETRGKGINTFDAKNLNETLFTLLSQ LIGYTGKEIVSGTSVFNEPAAVDAHANAQAVYDYYSKTFGRDSFDQNGARITSTVHVG KQWNNAAWNGVQMVYGDGDGSKFKPLSGSLDIVAHEITHAVTQYSAGLLYQGEPGALN ESISDIMGAMADRDDWEIGEDVYTPGIAGDSLRSLEDPSKQGNPDHYSNRYTGTEDYG GVHINSSIHNKAAYLLAEGGVHHGVQVEGIGREASEQIYYRALTYYVTASTDFSMMKQ AAIEAANDLYGEGSKQSASVEKAYEAVGIL*" gene 1186037..1187653 /gene="nprB" /locus_tag="BSU_11100" /old_locus_tag="BSU11100" downshifts 1187641 /Source="Nicolas_upshifts" /id="D603" /incds=0 /nref=2 /ntot=55 /MaxReadThrough="0.278770000000001" /MaxDrop="3.08544" /score="2.81939887" /energy="-8.6" /TU="NA" /idTUdmin="U890" /TUdmin=1760 /isTUend="FALSE" CDS complement(1187700..1188551) /gene="fakBB" /locus_tag="BSU_11110" /old_locus_tag="BSU11110" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25002480, 26774272, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid kinase fatty acid binding subunit B" /protein_id="NP_388992.1" /db_xref="EnsemblGenomes-Gn:BSU11110" /db_xref="EnsemblGenomes-Tr:CAB12951" /db_xref="GOA:P70945" /db_xref="InterPro:IPR003797" /db_xref="SubtiList:BG12244" /db_xref="UniProtKB/Swiss-Prot:P70945" /translation="MTVHLIADSATDLPRSYFEEKGIGFIPLRVSLGDKEFEDAVTIH ADQIFEAMQNGETPKTSQASPQTIKNVFLQYAETGDPALYIAFSSGLSGTYQTAVMIA NEVKEEFPDFDLRVIDSKCASLGYGLAVRHAADLCINGNTIQEIETSVKNFCSQLEHI FTVDDLTYLARGGRISKTSAFVGGLLNIKPLLQMEDGKLVPLEKIRGQKKLFKRIIEL MKERGDDWSNQTVGISYAANKEKATDMKHLIEEAFKPKEIIMHPISSAIGSHAGPGTL AIFFLRK*" gene complement(1187700..1188551) /gene="fakBB" /locus_tag="BSU_11110" /old_locus_tag="BSU11110" downshifts complement(1187717) /Source="Nicolas_upshifts" /id="D604" /incds=0 /nref=209 /ntot=263 /MaxReadThrough="0.727580000000001" /MaxDrop="6.86927" /score="-1.24586831" /energy="-7.7" /TU="NA" /idTUdmin="U892" /TUdmin=0 /isTUend="TRUE" promotor_-35 1188098..1188105 /Source="Nicolas_upshift_promotors" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1188120..1188139 /Source="Nicolas_upshift_promotors" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1188125..1188650 /Source="Nicolas_S_feature" /locus_tag="new_1188125_1188650" /HighExp="G180, Paraq, G135, G150, Oxctl, C30, H2O2, LBGstat, LBGexp, Lbexp" /AntisenseName="yitS" /AntisenseCor="-0.45830528686941202" /AntisenseRegPval="-14.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S395" upshifts 1188127 /Source="Nicolas_upshifts" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" promotor_-10 complement(1188592..1188611) /Source="Nicolas_upshift_promotors" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1188615) /Source="Nicolas_upshifts" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" promotor_-35 1188629..1188634 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1188631) /Source="Nicolas_upshift_promotors" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1188649..1188667 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1188652 /Source="Nicolas_upshifts" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" CDS 1188689..1189531 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23419162, 23824080; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388993.1" /db_xref="EnsemblGenomes-Gn:BSU11120" /db_xref="EnsemblGenomes-Tr:CAB12952" /db_xref="GOA:P39803" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG10850" /db_xref="UniProtKB/Swiss-Prot:P39803" /translation="MVLDQTKKLLIVIIGALLNAAGLNLFLIPADVYASGFTGVAQLL SSVVDQYAPFYISTGTLLFLLNIPVGILGWLKVGKSFTVYSILSVALTTLFMGILPET SLSHDILLNAVFGGVISAVGIGLTLKYGASTGGLDIVAMVLAKWKDKPVGTYFFILNG IIILTAGLLQGWEKALYTLVTLYVTTRVIDAIHTRHMKLTAMIVTKKADEIKEAIYGK MVRGITTVPAKGAFTNEQKEMMIIVITRYELYDLEKIVKEVDPKAFTNIVQTTGIFGF FRKD*" gene 1188689..1189531 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" promotor_-35 1189184..1189192 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1189203..1189221 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1189203 /Source="Nicolas_upshifts" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" S_feature 1189532..1189645 /Source="Nicolas_S_feature" /locus_tag="new_1189532_1189645" /HighExp="Etha, S8, Sw, M9-stat, S7, BC, Gly, S6, Salt, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigB, SigA" /TUshortPSig="0.968, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S396" CDS 1189646..1190005 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8226659, 24555072" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226659, 24555072; Product type f: factor" /codon_start=1 /transl_table=11 /product="intracellular proteinase inhibitor BsuPI" /protein_id="NP_388994.1" /db_xref="EnsemblGenomes-Gn:BSU11130" /db_xref="EnsemblGenomes-Tr:CAB12953" /db_xref="GOA:P39804" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR020481" /db_xref="PDB:3ISY" /db_xref="SubtiList:BG10852" /db_xref="UniProtKB/Swiss-Prot:P39804" /translation="MENQEVVLSIDAIQEPEQIKFNMSLKNQSERAIEFQFSTGQKFE LVVYDSEHKERYRYSKEKMFTQAFQNLTLESGETYDFSDVWKEVPEPGTYEVKVTFKG RAENLKQVQAVQQFEVK*" gene 1189646..1190005 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" downshifts 1189994 /Source="Nicolas_upshifts" /id="D605" /incds=0 /nref=34 /ntot=224 /MaxReadThrough="1.36729" /MaxDrop="5.6855" /score="43.7575824" /energy="-15.6" /TU="NA" /idTUdmin="U893" /TUdmin="-1" /isTUend="TRUE" CDS complement(1190036..1190233) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; genus orphan" /protein_id="YP_003097702.1" /db_xref="EnsemblGenomes-Gn:BSU11139" /db_xref="EnsemblGenomes-Tr:CAX52590" /db_xref="InterPro:IPR024217" /db_xref="UniProtKB/Swiss-Prot:C0H3Y5" /translation="MRNELFQQAKSFVQQAVMVTNGFEEGDQEQAILRAKNAVSSAYA NSTDAERQQLHQFQNQLDKLQ*" gene complement(1190036..1190233) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" downshifts complement(1190049) /Source="Nicolas_upshifts" /id="D606" /incds=0 /nref=150 /ntot=257 /MaxReadThrough="1.42333" /MaxDrop="8.284" /score="2.35557074" /energy="-17.3" /TU="NA" /idTUdmin="U895" /TUdmin=0 /isTUend="TRUE" S_feature complement(1190234..1190430) /Source="Nicolas_S_feature" /locus_tag="new_1190234_1190430_c" /HighExp="S8, S6, S5, S7, nit, ferm, BT, G/S, Pyr, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99834599999999996" /TUshortSig="SigGF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S397" upshifts complement(1190430) /Source="Nicolas_upshifts" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" promotor_-10 complement(1190432..1190443) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1190458..1190464) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1190490..1191302) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25012491, 26316208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase (promiscuous)" /protein_id="NP_388995.1" /db_xref="EnsemblGenomes-Gn:BSU11140" /db_xref="EnsemblGenomes-Tr:CAB12954" /db_xref="GOA:P70947" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12245" /db_xref="UniProtKB/Swiss-Prot:P70947" /translation="METKPYLIALDLDGTLLKDDKTISENTLHTIQRLKDDGHYVCIS TGRPYRSSSMYYQQMELTTPIVNFNGAFVHHPQDDSWGRYHTSLPLDVVKQLVDISES YNVHNVLAEVIDDVYFHYHDEHLIDAFNMNTTNVTVGDLRENLGEDVTSVLIHAKEED VPAIRSYLSDVHAEVIDHRRWAAPWHVIEIIKSGMNKAVGLQKISDYYGVPRERIIAF GDEDNDLEMLEFAGCGVAMGNGIDAVKQIANRTTATNEEDGVARFLKEYFSL*" gene complement(1190490..1191302) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" promotor_-10 complement(1191340..1191359) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1191360..1191367 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1191360) /Source="Nicolas_upshifts" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" promotor_-35 complement(1191373..1191380) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1191379..1191398 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1191381 /Source="Nicolas_upshifts" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" CDS 1191423..1192190 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28293230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxylesterase" /protein_id="NP_388996.1" /db_xref="EnsemblGenomes-Gn:BSU11150" /db_xref="EnsemblGenomes-Tr:CAB12955" /db_xref="GOA:P70948" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12246" /db_xref="UniProtKB/Swiss-Prot:P70948" /translation="MIQIENQTVSGIPFLHIVKEENRHRAVPLVIFIHGFTSAKEHNL HIAYLLAEKGFRAVLPEALHHGERGEEMAVEELAGHFWDIVLNEIEEIGVLKNHFEKE GLIDGGRIGLAGTSMGGITTLGALTAYDWIKAGVSLMGSPNYVELFQQQIDHIQSQGI EIDVPEEKVQQLMKRLELRDLSLQPEKLQQRPLLFWHGAKDKVVPYAPTRKFYDTIKS HYSEQPERLQFIGDENADHKVPRAAVLKTIEWFETYL*" gene 1191423..1192190 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" promotor_-35 1192199..1192205 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1192219 /Source="Nicolas_upshifts" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" promotor_-10 1192220..1192239 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1192254..1192562 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9209063; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein involved in Fe-S cluster assembly, PaaD-like" /protein_id="NP_388997.1" /db_xref="EnsemblGenomes-Gn:BSU11160" /db_xref="EnsemblGenomes-Tr:CAB12956" /db_xref="InterPro:IPR002744" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG12247" /db_xref="UniProtKB/Swiss-Prot:P70949" /translation="MEEALKENIMGALEQVVDPELGVDIVNLGLVYDVDMDEDGLTHI TMTLTSMGCPLAPIIVDEVKKALADLPEVKDTEVHIVWNPPWTRDKMSRYAKIALGIQ *" gene 1192254..1192562 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" downshifts 1192547 /Source="Nicolas_upshifts" /id="D607" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="5.65659" /MaxDrop="4.5598" /score="14.9971829" /energy="-14.7" /TU="U897,U898" /idTUdmin="U897" /TUdmin="-2244" /isTUend="FALSE" S_feature 1192592..1192857 /Source="Nicolas_S_feature" /locus_tag="new_1192592_1192857" /HighExp="Etha, dia15, dia5, H2O2, LoTm, Salt, S6, Diami, S8, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S398" CDS 1192858..1194288 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16956367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN/FAD-binding oxidoreductase" /protein_id="NP_388999.3" /db_xref="EnsemblGenomes-Gn:BSU11170" /db_xref="EnsemblGenomes-Tr:CAB12958" /db_xref="GOA:Q796P5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12249" /db_xref="UniProtKB/Swiss-Prot:Q796P5" /translation="MKKKLLAFALCTGAYAALFAYSVNSEQKTATSEMTDVSRLMPVK IKQTVKGQEEEMLIDTVKEANRKNIKISIAGAQHSMGGHTYYEDGIVLDMTGYNKILS LDQEKKTIRVQSGATWNDIQKYVNPYGLAVKVMQSQNIFTIGGSLSANAHGRDIRYGS LIDTVKSFRLLKADGMIITVTPKDDLFTAVIGGYGLFGVILDVTLELTDDELYVMKTE KMNYSTYSDYFSKHVKGNPDVRMHLARISTAKKGFLKDMYVTNYVLANHQDQLSSYSE LKEDEYTGATKFALGLSRRYEWGRNWLWDTQQSYFLSQNGTEISRNNVMRSESKFLEY ENNDNTDVLQEYFVPVKEYGSYIDDLRQTLSDEDLNLLNITIRYVQKNEKADLSYAKD DMFSLVLLINEGFSKEDQADTARIIRRMTDVAIKHGGSYYLPYMTYQTKAQMRQAYPK SEAFFQKKRTYDPDERFMNYFYQRYK*" gene 1192858..1194288 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" CDS 1194333..1194827 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transport protein" /protein_id="NP_389000.1" /db_xref="EnsemblGenomes-Gn:BSU11180" /db_xref="EnsemblGenomes-Tr:CAB12959" /db_xref="GOA:P70952" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12250" /db_xref="UniProtKB/Swiss-Prot:P70952" /translation="MFFASSLIFPFYILFVKNIGSSYTQFGFSYGLFGLSGALIYPLL GRLSERFDSRYFLLLNSWGMAVLLLYVPHIGSVVQVYIVQVLLGLFGAMQKHGEKVLI ANFTDSGERGKKIGNYHFWTAVFSAAAIMLGGFLADFFTVQMIFYASSILYFLSGLMM MKTG*" gene 1194333..1194827 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" downshifts 1194791 /Source="Nicolas_upshifts" /id="D608" /incds=0 /nref=49 /ntot=208 /MaxReadThrough="1.74762" /MaxDrop="4.22077" /score="34.1294744" /energy="-13.2" /TU="NA" /idTUdmin="U897" /TUdmin=0 /isTUend="TRUE" promotor_-35 1194965..1194972 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1194971 /Source="Nicolas_upshifts" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" promotor_-10 1194986..1195005 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1195034..1196071 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" /EC_number="1.2.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate gamma-semialdehyde dehydrogenase" /protein_id="NP_389001.2" /db_xref="EnsemblGenomes-Gn:BSU11190" /db_xref="EnsemblGenomes-Tr:CAB12960" /db_xref="GOA:P23715" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR000706" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR023013" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10191" /db_xref="UniProtKB/Swiss-Prot:P23715" /translation="MKIGIVGATGYGGTELVRILSHHPHAEECILYSSSGEGNVYSEG YPHLTGLADQQLKPIDMNTIKHEIDIMFLAAPPGVSSELTPKLADAGITVIDLSGDLR IKEPAEYEKWYKRTAAPKAVIQEAVYGLAELNQLQIQQAKLIANPGCFPTAVLLGLAP LAQKKLLDESFVIVDAKTGVSGAGRKASMGTHFSELNDNFKIYKVNEHQHTPEIEQAL NEWQPGLGPITFSAHLVPMTRGIMATMYTRLTCDLTADDLHDLYSEFYQDSYFVRVRP KGQYPQTKEVYGSNFCDIAVTLDERTNRVTIVSVIDNLMKGAAGQAVQNFNLMNGWNE ETGLTITPIYP*" gene 1195034..1196071 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" CDS 1196091..1197311 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" /EC_number="2.3.1.1" /EC_number="2.3.1.35" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8025667, 10931207, 16409639, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8025667, 10931207, 16409639, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine acetyltransferase; amino-acid acetyltransferase" /protein_id="NP_389002.2" /db_xref="EnsemblGenomes-Gn:BSU11200" /db_xref="EnsemblGenomes-Tr:CAB12961" /db_xref="GOA:P36843" /db_xref="InterPro:IPR002813" /db_xref="InterPro:IPR016117" /db_xref="SubtiList:BG10192" /db_xref="UniProtKB/Swiss-Prot:P36843" /translation="MIQLSEDQIVKVTGDVSSPKGFQAKGVHCGLRYSKKDLGVIISE TPAVSAAVYTQSHFQAAPIKVTQDSLKHGPTLKAVIVNSAIANACTGEQGLKDAYTMR ESFASQLGIEPELVAVSSTGVIGEHLDMEKIHAGIELLKETPAGSGDFEEAILTTDTV IKQTCYELAIGGKTVTIGGAAKGSGMIHPNMATMLGFVTTDAAIEEKALQKALREITD VSFNQITVDGETSTNDMVLVMANGCAENECLTEDHPDWPVFKKALLLTCEDLAKEIAR DGEGATKLIEAQVQGAKNNLDANVIAKKIVGSNLVKTAVYGTDANWGRIIGAIGHSAA QVTAEEVEVYLGGQCLFKNNEPQPFSESIAKEYLEGDEITIVIKMAEGDGNGRAWGCD LTYDYIKINASYRT*" gene 1196091..1197311 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" CDS 1197326..1198102 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" /EC_number="2.7.2.8" /experiment="publication(s) with functional evidences, PMID:3005232, 8473852" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3005232, 8473852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate 5-phosphotransferase (acetylglutamate kinase)" /protein_id="NP_389003.1" /db_xref="EnsemblGenomes-Gn:BSU11210" /db_xref="EnsemblGenomes-Tr:CAB12962" /db_xref="GOA:P68729" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR004662" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10193" /db_xref="UniProtKB/Swiss-Prot:P68729" /translation="MKKTIVFKCGGSVIRELSEEFYQNLKELRASGWKLAIVHGGGPE ITNMLKRLNIKTEFSGGQRKTTKPVLEVAEMVLSGSVNKFFVAELAKHGLRAAGISGK DGGLLEADYLDPETYGEVGEIKKVDASMVNALMENGIIPVIAPLSMTSDCKTLNVNAD LAASAVAGALEADKLMFVTDVDGIMKEKQRLDVLTPKEIQMLIKQEVITGGMIPKVNS ALSALSDQVSEVMIVNGKGSFFAEQTFQGTKIVKAKEAVS*" gene 1197326..1198102 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" CDS 1198099..1199256 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" /EC_number="2.6.1.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17012789; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylornithine aminotransferase" /protein_id="NP_389004.2" /db_xref="EnsemblGenomes-Gn:BSU11220" /db_xref="EnsemblGenomes-Tr:CAB12963" /db_xref="GOA:P36839" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10194" /db_xref="UniProtKB/Swiss-Prot:P36839" /translation="MSSLFQTYGRWDIDIKKAKGTYVEDQNGKTYLDFIQGIAVSNLG HCHEAVTEAVKKQLDSVWHVSNLFQNSLQEQAAQKLAAHSAGDLVFFCNSGAEANEGA IKLARKATGKTKIITFLQSFHGRTYAGMAATGQDKIKTGFGPMLGGFHYLPYNDPSAF KALGEEGDIAAVMLETVQGEGGVNPASAEFLSAVQSFCKEKQALLIIDEIQTGIGRTG KGFAYEHFGLSPDIITVAKGLGNGFPVGAVIGKKQLGEAFTPGSHGTTFGGNMLAMAA VNATLQIVFQPDFLQEAADKGAFLKEQLEAELKSPFVKQIRGKGLMLGIECDGPVADI IAELQTLGLLVLPAGPNVIRLLPPLTVTKDEIAEAVSKLKQAIAHHSAVNQ*" gene 1198099..1199256 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" CDS 1199327..1200388 /gene="carA" /locus_tag="BSU_11230" /old_locus_tag="BSU11230" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 230177, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 230177, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(small subunit)" /protein_id="NP_389005.2" /db_xref="EnsemblGenomes-Gn:BSU11230" /db_xref="EnsemblGenomes-Tr:CAB12964" /db_xref="GOA:P36838" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10195" /db_xref="UniProtKB/Swiss-Prot:P36838" /translation="MEGYLVLEDGTSFSGELDGHENCTGEAVFFTGMTGYQEVLTDPS YKGQIIVFTYPLIGNYGINEKDFESKKPQVKAAVVYEACDHFSHYEAVYSLKEYLQKW NIPLLTHVDTRAVVKKIRANGTMGATVTASKEGAEIALQPENVAEQASAQEISTFGDG NKHIALIDFGYKKSIASSLVKRGCKVTVVPYQQMEAVYNIKPDGIVLSNGPGDPKAIQ PYLGKIKSIISRFPTLGICLGHQLIALAFGGNTFKLPFGHRGANHPVIDRKTKRVFMT SQNHSYVVDEQSINEEELTIRFHHVNDTSVEGLAHKKLPVMSVQFHPEAHPGPAESEW IFDDYLKNVIPARREIAHA*" gene 1199327..1200388 /gene="carA" /locus_tag="BSU_11230" /old_locus_tag="BSU11230" misc_feature complement(1200222..1200241) /Source="Nicolas_upshift_promotors" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1200232) /Source="Nicolas_upshifts" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1200381..1203473 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(large subunit)" /protein_id="NP_389006.3" /db_xref="EnsemblGenomes-Gn:BSU11240" /db_xref="EnsemblGenomes-Tr:CAB12965" /db_xref="GOA:P18185" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR036897" /db_xref="SubtiList:BG10196" /db_xref="UniProtKB/Swiss-Prot:P18185" /translation="MPKDTSISSILVIGSGPIIIGQAAEFDYSGTQGCIALKEEGYRV ILVNSNPATIMTDEAFADEIYFEPLTAESLTAIIKKERPDGLLANLGGQTALNLAVEL EETGVLKEHGVKLLGTSVETIQKGEDREKFRSLMNELKQPVPESEIVDNEADALHFAE SIGFPVIIRPAYTLGGKGGGIAPDKEAFTAMIKQALLASPINQCLVEKSIAGFKEIEY EVMRDSNNTCITVCNMENIDPVGVHTGDSIVVAPSQTLTDEDYQMLRTASLTIISALD VVGGCNIQFALDPFSKQYYVIEVNPRVSRSSALASKATGYPIAKMAAKLAVGYTLDEL KNPLTGSTYASFEPALDYVIVKFPRWPFDKFKNADRKLGTKMKATGEVMAIERNLEAA IQKAAASLELKNIGTHLPELSGLSIDTLWDLAITPDDRRFFVVMELLSRSVSIDDIHE KTKIDPFFLHTFDNIIKLENRLMEAGSDLSFELLKKAKEKGFSDATIASLISKTEEEV RALRKEMGITPSFKIVDTCAAEFDAKTNYFYSTYFGETDGDISRKEKKRALIIGSGPI RIGQGVEFDYSAVHGVLTLQELGFETIMINNNPETVSTDYEIADRLYFEPMTTEHIVN VAEQENIDFAIVQFGGQTAINAAEALEKAGITLLGTSFQTLDVLEDRDQFYQLLDELG LKHAKGEIAYTKEEAASKASEIGYPVLIRPSYVIGGMGMIIVDSQAQLSQLLNDEDSM PYPILIDQYVSGKEVEIDLISDGEEVFIPTYTEHIERAGVHSGDSFAILPGPSITSGL QQGMKDAAQKIARKLSFKGIMNIQFVIDNGNILVLEVNPRASRTVPVVSKVMGVPMIP LATRLLAGASLKDLNPAVQNHHGVAVKFPVFSSHAIQDVDVKLGPEMKSTGEGMCVAY DSNSALKKIYTRVWSQKGSIYLQNVPEDVKELAENAGFTIHEGTFASWMEQEGNSLHI NLSGSEEARKERLEAMTHGIPVFTEEETVRAFLQSGSGHPQPVSLKDLYKKEVASCTQ *" gene 1200381..1203473 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" CDS 1203461..1204420 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" /EC_number="2.1.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3099126, 6409881, 8025667, 9346304, 16585758, 26443366" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3099126, 6409881, 8025667, 9346304, 16585758, 26443366; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ornithine carbamoyltransferase" /protein_id="NP_389007.1" /db_xref="EnsemblGenomes-Gn:BSU11250" /db_xref="EnsemblGenomes-Tr:CAB12966" /db_xref="GOA:P18186" /db_xref="InterPro:IPR002292" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR024904" /db_xref="InterPro:IPR036901" /db_xref="SubtiList:BG10197" /db_xref="UniProtKB/Swiss-Prot:P18186" /translation="MHTVTQTSLYGKDLLTLKDLSEEDINALLAEAGELKQNKIQPIF HGKTLAMIFEKSSTRTRVSFEAGMAQLGGSALFLSQKDLQLGRGETVADTAKVLSGYV DAIMIRTFEHEKVEELAKEADIPVINGLTDKYHPCQALADLLTIKEIKGKLKGVKVAY IGDGNNVAHSLMIGCAKMGCDISIASPKGYEVLDEAAEAAKTYALQSGSSVTLTDDPI EAVKDADVIYSDVFTSMGQEAEEQERLAVFAPYQVNAALVSHAKPDYTFLHCLPAHRE EEVTAEIIDGPNSAVFQQAENRLHVQKALLKAILYKGESSKNC*" gene 1203461..1204420 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" downshifts 1204383 /Source="Nicolas_upshifts" /id="D609" /incds=0 /nref=141 /ntot=268 /MaxReadThrough="4.29547" /MaxDrop="7.69347" /score="22.2660758" /energy="-11.1" /TU="U899" /idTUdmin="U899" /TUdmin="-305" /isTUend="FALSE" S_feature complement(1204423..1204697) /Source="Nicolas_S_feature" /locus_tag="new_1204423_1204697_c" /HighExp="G135, G180, Cold, LBGexp, G150, B60, LoTm, Paraq, Oxctl, H2O2" /AntisenseName="yjzC" /AntisenseCor="-0.37122740772860502" /AntisenseRegPval="-9.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S399" promotor_-35 1204448..1204454 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1204456) /Source="Nicolas_upshifts" /id="D610" /incds=0 /nref=33 /ntot=166 /MaxReadThrough="1.19008" /MaxDrop="5.22155" /score="16.2777759" /energy="-11.2" /TU="NA" /idTUdmin="U902" /TUdmin=0 /isTUend="TRUE" promotor_-10 1204469..1204480 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1204490 /Source="Nicolas_upshifts" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" CDS 1204506..1204685 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25859258" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389008.1" /db_xref="EnsemblGenomes-Gn:BSU11260" /db_xref="EnsemblGenomes-Tr:CAB12967" /db_xref="InterPro:IPR025549" /db_xref="SubtiList:BG13223" /db_xref="UniProtKB/Swiss-Prot:O34585" /translation="MGQQHQFRPGQKAPNNGVYVEIGETGSMVKNPQKVHLSAGEMFP ETSNHNRLWTYKRKP*" gene 1204506..1204685 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" downshifts 1204695 /Source="Nicolas_upshifts" /id="D611" /incds=0 /nref=19 /ntot=53 /MaxReadThrough="0.25116" /MaxDrop="5.67653" /score="4.8153862" /energy="-10.9" /TU="NA" /idTUdmin="U899" /TUdmin=7 /isTUend="TRUE" CDS complement(1204731..1204916) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19775244" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19775244; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore targeted protein" /protein_id="NP_389009.1" /db_xref="EnsemblGenomes-Gn:BSU11270" /db_xref="EnsemblGenomes-Tr:CAB12968" /db_xref="GOA:O34713" /db_xref="InterPro:IPR021324" /db_xref="SubtiList:BG13224" /db_xref="UniProtKB/Swiss-Prot:O34713" /translation="MRYIIAFIWTFLLSHMACYLVASMNSVTYNFKTSSVIAVVLYVL IMVLAEIMPMNKNASQH*" gene complement(1204731..1204916) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" downshifts complement(1204742) /Source="Nicolas_upshifts" /id="D612" /incds=0 /nref=215 /ntot=261 /MaxReadThrough="3.91391" /MaxDrop="6.26103" /score="9.62656276" /energy="-10.9" /TU="U902" /idTUdmin="U902" /TUdmin="-286" /isTUend="FALSE" promotor_-10 complement(1204945..1204964) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1204962) /Source="Nicolas_upshifts" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" promotor_-35 complement(1204975..1204982) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1205017..1205023 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1205035..1205054 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1205040 /Source="Nicolas_upshifts" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 1205097..1205106 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1205106 /Source="Nicolas_upshifts" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" promotor_-10 1205119..1205138 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1205165..1205899 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 18582593" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389010.1" /db_xref="EnsemblGenomes-Gn:BSU11280" /db_xref="EnsemblGenomes-Tr:CAB12969" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13124" /db_xref="UniProtKB/Swiss-Prot:O35001" /translation="MGITERYFQLGTEHNVIHLPYRPNGFGIFILGDRTHFVGHDSSF WQQHYGRNQLLSMLMNEGYTLFNSNLFGRHWGAEKAVTYAKQLIHSVLKQEILNPKIH ILAEGMGALVADELLRFSPDHIRSAAMLNPCLDLQAHYESEKENKFFYKQFLKEVSKS YGISEKEAEAIRYKTIQSYPSGVPVHIWQRMTGAPYPYSVHAEVFKEKQQKQGSPVDM TFHLFEHPSRIYASICKFFHSHEKEL*" gene 1205165..1205899 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" S_feature complement(1205658..1206260) /Source="Nicolas_S_feature" /locus_tag="new_1205658_1206260_c" /HighExp="S8, S6, S7, C30, BT, S4, S5, Pyr, S3, C90" /AntisenseName="yjaV" /AntisenseCor="0.66207512383157796" /AntisenseRegPval="-34.6" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.468" /TUlongSig="NA" /TUlongPSig="NA" /label="S400" promotor_-35 1205880..1205885 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1205898 /Source="Nicolas_upshifts" /id="D613" /incds=0 /nref=6 /ntot=47 /MaxReadThrough="5.56163" /MaxDrop="4.5381" /score="1.90624641" /energy="-10" /TU="U904,U905" /idTUdmin="U904" /TUdmin="-945" /isTUend="FALSE" upshifts 1205898 /Source="Nicolas_upshifts" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" promotor_-10 1205901..1205919 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1205981..1206538 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P) binding enzyme" /protein_id="NP_389011.2" /db_xref="EnsemblGenomes-Gn:BSU11290" /db_xref="EnsemblGenomes-Tr:CAB12970" /db_xref="SubtiList:BG13125" /db_xref="UniProtKB/Swiss-Prot:O34959" /translation="MESTLIVGADEFFGLSLCERMMDEGIHVDVVLAETEDKMRQMYL EERLMWLGRNELFRQLEHIGDQNYDTICIQFGSFLPLDQYDSPYILVYEEDRKEWDKR EKTGSEKTVILPKMYGPWKEETEEDGYYTNDVADELLRFLLEPSRHSKDQLFELQVTE KTSKEEAKTKIIEWKRQFSSIFDKY*" gene 1205981..1206538 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" promotor_-10 complement(1206240..1206259) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1206260) /Source="Nicolas_upshifts" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" promotor_-35 complement(1206274..1206278) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1206545..1206552 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 1206567..1206586 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 1206579 /Source="Nicolas_upshifts" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" CDS 1206629..1207582 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1203607, 21622736, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1203607, 21622736, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="positive regulator of comK" /protein_id="NP_389012.2" /db_xref="EnsemblGenomes-Gn:BSU11300" /db_xref="EnsemblGenomes-Tr:CAB12971" /db_xref="GOA:O32436" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13126" /db_xref="UniProtKB/Swiss-Prot:O32436" /translation="MITRLVMIFSVLLLLSGCGQTPFKGKIEKVGMLFPDTINDLVWG TKGYKGLLNIQSKYNVDVYYKEGVKTEEDIINAIEDFHKRGVNLLYGHGSEYAEVFNL VGEDYPDMEFVISNAKAKADNVTSVHFSGEAMGFFGGMTAAHMSKTNQVGVIASFTWQ PEVDGFIKGAKYENPDIEVNTKYTDHWDDDTTAVKLYQKMKNEGADVVYPAGDGYNVP VIQQIKKDGLYAIGYVTDQSDLGENTVLTSTVQNVDKAYEIIAEQFNKGTLEGGDHYY DLNTGVVEMGTFSPLVDQDFQQRIAKLIKTYNKTGELPKNE*" gene 1206629..1207582 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" promotor_-35 1207246..1207250 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 1207266..1207285 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 1207279 /Source="Nicolas_upshifts" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" CDS 1207597..1207788 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10940045; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative late competence gene" /protein_id="NP_389013.1" /db_xref="EnsemblGenomes-Gn:BSU11310" /db_xref="EnsemblGenomes-Tr:CAB12972" /db_xref="GOA:O32437" /db_xref="InterPro:IPR024558" /db_xref="SubtiList:BG13221" /db_xref="UniProtKB/Swiss-Prot:O32437" /translation="MQHEKSLEFLQIAMKYLPEAKEQLEKSGIELSMEAIQPFMNLFT TVMAEAYELGKSDAKSETE*" gene 1207597..1207788 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" downshifts 1207767 /Source="Nicolas_upshifts" /id="D614" /incds=0 /nref=32 /ntot=192 /MaxReadThrough="4.56858" /MaxDrop="3.45953" /score="-7.49795364" /energy="-10.4" /TU="U907,U908" /idTUdmin="U905" /TUdmin=0 /isTUend="TRUE" S_feature 1207812..1208152 /Source="Nicolas_S_feature" /locus_tag="new_1207812_1208152" /HighExp="H2O2, C30, G135, Paraq, G180, G150, Oxctl, Cold, dia15, LPh" /AntisenseName="yjzB" /AntisenseCor="-0.34349942363230701" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S401" CDS complement(1207818..1208057) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" /experiment="publication(s) with functional evidences, PMID:16391061, 22171814, 27227299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16391061, 22171814, 27227299; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389014.1" /db_xref="EnsemblGenomes-Gn:BSU11320" /db_xref="EnsemblGenomes-Tr:CAB12973" /db_xref="SubtiList:BG13222" /db_xref="UniProtKB/Swiss-Prot:O34891" /translation="MQLDVFSRMMFGDAAKPTEEKEEEQQEEVSQVSQTNDEETINYM HIMDQIGSIMNSLDQIKPALKELAPMLSAIKKKIM*" gene complement(1207818..1208057) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" downshifts complement(1207834) /Source="Nicolas_upshifts" /id="D615" /incds=0 /nref=21 /ntot=48 /MaxReadThrough="1.43519" /MaxDrop="5.47891" /score="-7.75082002" /energy="-10.4" /TU="NA" /idTUdmin="U909" /TUdmin="-13" /isTUend="TRUE" promotor_-10 complement(1208070..1208089) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1208091) /Source="Nicolas_upshifts" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" promotor_-35 complement(1208103..1208112) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1208118..1208125 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1208140..1208159 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1208154 /Source="Nicolas_upshifts" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" CDS 1208222..1209160 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 11959561, 21542858, 25196128" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 11959561, 21542858, 25196128; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 1" /protein_id="NP_389015.1" /db_xref="EnsemblGenomes-Gn:BSU11330" /db_xref="EnsemblGenomes-Tr:CAB12974" /db_xref="GOA:O34746" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13127" /db_xref="UniProtKB/Swiss-Prot:O34746" /translation="MKAGILGVGRYIPEKVLTNHDLEKMVETSDEWIRTRTGIEERRI AADDVFSSHMAVAAAKNALEQAEVAAEDLDMILVATVTPDQSFPTVSCMIQEQLGAKK ACAMDISAACAGFMYGVVTGKQFIESGTYKHVLVVGVEKLSSITDWEDRNTAVLFGDG AGAAVVGPVSDDRGILSFELGADGTGGQHLYLNEKRHTIMNGREVFKFAVRQMGESCV NVIEKAGLSKEDVDFLIPHQANIRIMEAARERLELPVEKMSKTVHKYGNTSAASIPIS LVEELEAGKIKDGDVVVMVGFGGGLTWGAIAIRWGR*" gene 1208222..1209160 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" promotor_-35 1208299..1208308 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1208317 /Source="Nicolas_upshifts" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" promotor_-10 1208320..1208335 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1209183..1210424 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" /EC_number="2.3.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11325930, 12682299, 16436705, 18384517, 21542858, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325930, 12682299, 16436705, 18384517, 21542858, 28196402; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase II (involved in pimelate synthesis)" /protein_id="NP_389016.1" /db_xref="EnsemblGenomes-Gn:BSU11340" /db_xref="EnsemblGenomes-Tr:CAB12975" /db_xref="GOA:O34340" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR017568" /db_xref="InterPro:IPR018201" /db_xref="InterPro:IPR020841" /db_xref="PDB:4LS5" /db_xref="PDB:4LS6" /db_xref="PDB:4LS7" /db_xref="PDB:4LS8" /db_xref="SubtiList:BG13128" /db_xref="UniProtKB/Swiss-Prot:O34340" /translation="MTKKRVVVTGLGALSPLGNDVDTSWNNAINGVSGIGPITRVDAE EYPAKVAAELKDFNVEDYMDKKEARKMDRFTQYAVVAAKMAVEDADLNITDEIAPRVG VWVGSGIGGLETLESQFEIFLTKGPRRVSPFFVPMMIPDMATGQISIALGAKGVNSCT VTACATGTNSIGDAFKVIQRGDADVMVTGGTEAPLTRMSFAGFSANKALSTNPDPKTA SRPFDKNRDGFVMGEGAGIIVLEELEHALARGAKIYGEIVGYGSTGDAYHITAPAQDG EGGARAMQEAIKDAGIAPEEIDYINAHGTSTYYNDKYETMAIKTVFGEHAHKLAVSST KSMTGHLLGAAGGIEAIFSILAIKEGVIPPTINIQTPDEECDLDYVPDEARRQELNYV LSNSLGFGGHNATLIFKKYQS*" gene 1209183..1210424 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" promotor_-10 complement(1209397..1209415) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1209405) /Source="Nicolas_upshifts" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1209431..1209436) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1210275 /Source="Nicolas_upshifts" /id="D616" /incds=1 /nref=1 /ntot=89 /MaxReadThrough="7.03006" /MaxDrop="2.1101" /score="54.6350161" /energy="-18.5" /TU="U910,U911" /idTUdmin="U911" /TUdmin="-132" /isTUend="FALSE" downshifts 1210408 /Source="Nicolas_upshifts" /id="D617" /incds=0 /nref=246 /ntot=274 /MaxReadThrough="0.58964" /MaxDrop="7.80446" /score="54.6350161" /energy="-18.5" /TU="NA" /idTUdmin="U911" /TUdmin=1 /isTUend="TRUE" promotor_-35 1210449..1210458 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-35" promotor_-10 1210471..1210490 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-10" upshifts 1210473 /Source="Nicolas_upshifts" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" promotor_-35 1210485..1210493 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1210500..1211285 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389017.1" /db_xref="EnsemblGenomes-Gn:BSU11350" /db_xref="EnsemblGenomes-Tr:CAB12992" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13129" /db_xref="UniProtKB/Swiss-Prot:O31596" /translation="MSVEQTYSWLRKAGSIDDLAHYIIPLFSGAEKKNWKGILGHLQH HGMFKNIKEGIQTVSKLKEKGFYGHIQKEEQYLKNKWQGPDVPIVTLPVDERNRRIRL EFGSKSGLAFQDKMFLFLSSDLDFGSVSALMTHEYHHVCRLGHLTKEEKDVTLLDTII MEGLAEYAVYERFGRSQTAEWTTWYTPEQLQALYEKKIAPHRDIKRDNRLFPQLLFGK GYQPKMLGYAVGFNIVKKYLTASKASTADGLSIPAETFLDAML*" gene 1210500..1211285 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" promotor_-10 1210505..1210523 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1210517 /Source="Nicolas_upshifts" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature 1211286..1211370 /Source="Nicolas_S_feature" /locus_tag="new_1211286_1211370" /HighExp="S6, S5, S8, S7, BT, S4, S3, B36, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S402" promotor_-10 complement(1211302..1211320) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1211319) /Source="Nicolas_upshifts" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1211335..1211340) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1211338..1211345 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1211360..1211379 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1211372..1211476 /Source="Nicolas_S_feature" /locus_tag="new_1211372_1211476" /HighExp="LoTm, T4.0H, T3.0H, T5.0H, T3.30H, T2.30H, M9-stat, S1, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S403" upshifts 1211372 /Source="Nicolas_upshifts" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" CDS 1211477..1212463 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389018.1" /db_xref="EnsemblGenomes-Gn:BSU11360" /db_xref="EnsemblGenomes-Tr:CAB12993" /db_xref="GOA:P42064" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11085" /db_xref="UniProtKB/Swiss-Prot:P42064" /translation="MSTLLEVNNLKTYFFRKKEPIPAVDGVDFHISKGETVALVGESG SGKSITSLSIMGLVQSSGGKIMDGSIKLEDKDLTSFTENDYCKIRGNEVSMIFQEPMT SLNPVLTIGEQITEVLIYHKNMKKKEARQRAVELLQMVGFSRAEQIMKEYPHRLSGGM RQRVMIAIALSCNPKLLIADEPTTALDVTIQAQVLELMKDLCQKFNTSILLITHDLGV VSEAADRVIVMYCGQVVENATVDDLFLEPLHPYTEGLLTSIPVIDGEIDKLNAIKGSV PTPDNLPPGCRFAPRCPKAMDKCWTNQPSLLTHKSGRTVRCFLYEEEGAEQS*" gene 1211477..1212463 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" CDS 1212460..1213449 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389019.2" /db_xref="EnsemblGenomes-Gn:BSU11370" /db_xref="EnsemblGenomes-Tr:CAB12994" /db_xref="GOA:P42065" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11086" /db_xref="UniProtKB/Swiss-Prot:P42065" /translation="MTAANQETILELRDVKKYFPIRSGLFQRKVGDVKAVDGVSFSLK KGETLGIVGESGCGKSTAGRTMIRLYKPTEGQILFKGQDISNLSEEKLRKSVRKNIQM VFQDPFASLNPRKTLRSIIKEPFNTHNMYTMRERNEKVEELLARVGLHPSFAGRYPHE FSGGQRQRIGIARALTLNPELIIADEPVSALDVSIQAQVINLMEELQEEFNLTYLFIS HDLSVVRHISDRVGVMYLGKMMELTGKHELYDNPLHPYTQALLSSVPVTRKRGSVKRE RIVLKGELPSPANPPKGCVFHTRCPVAKPICKEQIPEFKEAAPSHFVACHLYS*" gene 1212460..1213449 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" misc_feature 1213455..1213461 /Source="Nicolas_upshift_promotors" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1213460..1213536 /Source="Nicolas_S_feature" /locus_tag="new_1213460_1213536" /HighExp="T2.0H, S1, M9-stat, T5.0H, T3.0H, T1.30H, S2, M0t90, T2.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="SigK" /TUlongPSig=1 /label="S404" upshifts 1213460 /Source="Nicolas_upshifts" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" CDS 1213537..1214028 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15588833, 25355936; Product type rc: receptor" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); N-terminal part of AppA" /translation="MKRRKTALMMLSVLMVLAIFLSACSGSKSSNSSAKKSAGKPQQG GDLVVGSIGEPTLFNSLYSTDDASTDIENMLYSFLTKTDEKLNVKLSLAESIKELDGG LAYDVKIKKGVKFHDGKELTADDVVFTYSVPLSKDYKGERGSTYEMLKSVEKKAITKS CLS*" gene 1213537..1214028 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /pseudo CDS 1214001..1215167 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7997159, 15588833, 26728191; Product type lp: lipoprotein" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); C-terminal part of AppA" /translation="GDYEVLFKLKYKDGNFYNNALDSTAILPKHILGNVPIADLEENE FNRKKPIGSGPFKFKEWKQGQYIKLEANDDYFEGRPYLDTVTYKVIPDANAAVAQLQA GDINFFNVPATDYKTAEKFNNLKIVTDLALSYVYIGWNEKNELFKDKKVRQALTTALD RESIVSQVLDGDGEVAYIPESPLSWNYPKDIDVPKFEYNEKKAKQMLAEAGWKDTNGD GILDKDGKKFSFTLKTNQGNKVREDIAVVVQEQLKKIGIEVKTQIVEWSALVEQMNPP NWDFDAMVMGWSLSTFPDQYDIFHSSQIKKGLNYVWYKNAEADKLMKDAKSISDRKQY SKEYEQIYQKIAEDQPYTFLYYPNNHMAMPENLEGYKYHPKRDLYNIEKWWLAK*" gene 1214001..1215167 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /pseudo downshifts 1215158 /Source="Nicolas_upshifts" /id="D618" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="7.71397" /MaxDrop="3.11667" /score="-1.00317393" /energy="-13.3" /TU="U916,U917" /idTUdmin="U913" /TUdmin=1715 /isTUend="FALSE" CDS 1215243..1216193 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389021.2" /db_xref="EnsemblGenomes-Gn:BSU11390" /db_xref="EnsemblGenomes-Tr:CAB12996" /db_xref="GOA:P42062" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11088" /db_xref="UniProtKB/Swiss-Prot:P42062" /translation="MAAYIIRRTLMSIPILLGITILSFVIMKAAPGDPMTLMMDPKIS QADREQFIEKYGLNDPQYVQYLKWLGNMVQGDFGTSIVRKGTPVSELIMARLPNTLLL MLVSTILALMISIPFGVLSAKRPYSKIDYGITFTSFIGLAIPNFWFGLILIMVLSVNL GWFPTGGVETLNTEFNIFDRIHHLILPAFVLATADMAGLTRYTRSNMLDVLNQDYIRT ARAKGFKENRVLFKHGLRNALLPVITIFGLMIPSFIGGSVVVEQIFTWPGLGKLFVDS AFQRDYPVIMAMTVISAVLVVVGNLIADILYAIVDPRIEY*" gene 1215243..1216193 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" CDS 1216210..1217121 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389022.1" /db_xref="EnsemblGenomes-Gn:BSU11400" /db_xref="EnsemblGenomes-Tr:CAB12997" /db_xref="GOA:P42063" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11089" /db_xref="UniProtKB/Swiss-Prot:P42063" /translation="MSELQTTPSPEIRLKENISKKPETMTKIFWEKFSKNKLAILGAV ILFIIIMSAVFAPLIAPYPQEQQSLLDKYKAPGLEHLMGTDKFGRDIFSRILYGARVS LLVGFASVVGSILIGTVLGALAGYFRGIVDAVIMRVVDIVLSIPDIFLLITLVTIFKP GVDKLILIFCLTGWTTTARLVRGEFLSLRSREYVLAAKTIGTKTHKIIFSHILPNALG PIIVSATLKVGSVILAESALSYLGFGIQPPIASWGNMLQDAQNFTVMIQAWWYPLFPG LFILMTVLCFNFVGDGLRDALDPKNIK*" gene 1216210..1217121 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" downshifts 1217135 /Source="Nicolas_upshifts" /id="D619" /incds=0 /nref=62 /ntot=188 /MaxReadThrough="5.13927" /MaxDrop="5.50153" /score="22.0028545" /energy="-11.6" /TU="U916,U917" /idTUdmin="U916" /TUdmin="-923" /isTUend="FALSE" S_feature 1217180..1217287 /Source="Nicolas_S_feature" /locus_tag="new_1217180_1217287" /HighExp="LoTm, S1, S2, BT, T3.30H, T4.0H, T5.0H, T3.0H, Glu, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S405" promotor_-35 1217260..1217265 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1217281..1217299 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1217289 /Source="Nicolas_upshifts" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" CDS 1217326..1218078 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717292, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation nucleic acid binding protein" /protein_id="NP_389023.1" /db_xref="EnsemblGenomes-Gn:BSU11410" /db_xref="EnsemblGenomes-Tr:CAB12998" /db_xref="InterPro:IPR020909" /db_xref="SubtiList:BG13130" /db_xref="UniProtKB/Swiss-Prot:O31597" /translation="MLFLHDVWVNWFEGEENGYNVCHFHEWRKEDTVELLDQVPLLRV PSVLFHYIENDLSELPKGLLEDVHQKSYIRKNHERTKLEYCFVVTDGIGILAVDTIGY TIPVRKSRLIPRQEQLVYEMVKDVEPETYEFEPKKLESSKEYHILSLAPEHVRGLTRK ERQIKQLMFMALDQLKGLKNRAEIGYWYTEWNPHMYEQIKRMSFEEIWDMLYNETIEG WSDKHLAFCENLIKGQPFFEKLWEMENESKVN*" gene 1217326..1218078 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" downshifts 1218058 /Source="Nicolas_upshifts" /id="D620" /incds=0 /nref=32 /ntot=112 /MaxReadThrough="1.07428" /MaxDrop="6.2264" /score="22.0028545" /energy="-11.6" /TU="NA" /idTUdmin="U916" /TUdmin=0 /isTUend="TRUE" CDS complement(1218113..1219105) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" /EC_number="6.1.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8950174, 10706627, 12682299, 24572018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8950174, 10706627, 12682299, 24572018; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophanyl-tRNA synthetase" /protein_id="NP_389024.1" /db_xref="EnsemblGenomes-Gn:BSU11420" /db_xref="EnsemblGenomes-Tr:CAB12999" /db_xref="GOA:P21656" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002306" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024109" /db_xref="PDB:3PRH" /db_xref="SubtiList:BG10799" /db_xref="UniProtKB/Swiss-Prot:P21656" /translation="MKQTIFSGIQPSGSVTLGNYIGAMKQFVELQHDYNSYFCIVDQH AITVPQDRLELRKNIRNLAALYLAVGLDPEKATLFIQSEVPAHAQAGWMMQCVAYIGE LERMTQFKDKSKGNEAVVSGLLTYPPLMAADILLYGTDLVPVGEDQKQHLELTRNLAE RFNKKYNDIFTIPEVKIPKVGARIMSLNDPLKKMSKSDPNQKAYITLLDEPKQLEKKI KSAVTDSEGIVKFDKENKPGVSNLLTIYSILGNTTIEELEAKYEGKGYGEFKGDLAEV VVNALKPIQDRYYELIESEELDRILDEGAERANRTANKMLKKMENAMGLGRKRR*" gene complement(1218113..1219105) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" downshifts complement(1218134) /Source="Nicolas_upshifts" /id="D621" /incds=0 /nref=224 /ntot=255 /MaxReadThrough="1.77115" /MaxDrop="6.72647" /score="27.6275522" /energy="-11.6" /TU="U919" /idTUdmin="U919" /TUdmin="-22" /isTUend="TRUE" misc_RNA complement(1219164..1219378) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" /product="T-box riboswitch specific of tryptophan tRNA" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" gene complement(1219164..1219378) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" downshifts complement(1219212) /Source="Nicolas_upshifts" /id="D622" /incds=0 /nref=37 /ntot=127 /MaxReadThrough="6.8472" /MaxDrop="5.13001" /score="25.1445248" /energy="-19" /TU="U919" /idTUdmin="U919" /TUdmin="-1100" /isTUend="FALSE" misc_feature complement(1219397..1219416) /Source="Nicolas_upshift_promotors" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1219410) /Source="Nicolas_upshifts" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" promotor_-35 1219665..1219672 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1219686..1219848 /Source="Nicolas_S_feature" /locus_tag="new_1219686_1219848" /HighExp="S1, T3.0H, T3.30H, T2.30H, T4.0H, T5.0H, LoTm, T2.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S406" promotor_-10 1219687..1219706 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1219687 /Source="Nicolas_upshifts" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" CDS 1219849..1221486 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (binding lipoprotein)" /protein_id="NP_389025.1" /db_xref="EnsemblGenomes-Gn:BSU11430" /db_xref="EnsemblGenomes-Tr:CAB13000" /db_xref="GOA:P24141" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10771" /db_xref="UniProtKB/Swiss-Prot:P24141" /translation="MKKRWSIVTLMLIFTLVLSACGFGGSGSNGEGKKDSKGKTTLNI NIKTEPFSLHPGLANDSVSGGVIRQTFEGLTRINADGEPEEGMASKIETSKDGKTYTF TIRDGVKWSNGDPVTAQDFEYAWKWALDPNNESQYAYQLYYIKGAEAANTGKGSLDDV AVKAVNDKTLKVELNNPTPYFTELTAFYTYMPINKKIAEKNKKWNTNAGDDYVSNGPF KMTAWKHSGSITLEKNDQYWDKDKVKLKKIDMVMINNNNTELKKFQAGELDWAGMPLG QLPTESLPTLKKDGSLHVEPIAGVYWYKFNTEAKPLDNVNIRKALTYSLDRQSIVKNV TQGEQIPAMAAVPPTMKGFEDNKEGYFKDNDVKTAKEYLEKGLKEMGLSKASDLPKIK LSYNTDDAHAKIAQAVQEMWKKNLGVDVELDNSEWNVYIDKLHSQDYQIGRMGWLGDF NDPINFLELFRDKNGGNNDTGWENPEFKKLLNQSQTETDKTKRAELLKKAEGIFIDEM PVAPIYFYTDTWVQDENLKGVIMPGTGEVYFRNAYFK*" gene 1219849..1221486 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" downshifts 1221380 /Source="Nicolas_upshifts" /id="D623" /incds=1 /nref=8 /ntot=166 /MaxReadThrough="6.94127" /MaxDrop="3.3677" /score="-4.2761508" /energy="-15.6" /TU="U920" /idTUdmin="U916" /TUdmin=3322 /isTUend="FALSE" S_feature 1221487..1221593 /Source="Nicolas_S_feature" /locus_tag="new_1221487_1221593" /HighExp="S1, LoTm, T4.0H, BT, T3.30H, T3.0H, T5.0H, M0t90, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S407" CDS 1221594..1222529 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 17600541, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 17600541, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389026.1" /db_xref="EnsemblGenomes-Gn:BSU11440" /db_xref="EnsemblGenomes-Tr:CAB13001" /db_xref="GOA:P24138" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10772" /db_xref="UniProtKB/Swiss-Prot:P24138" /translation="MLKYIGRRLVYMIITLFVIVTVTFFLMQAAPGGPFSGEKKLPPE IEANLNAHYGLDKPLFVQYVSYLKSVAMWDFGPSFKYKGQSVNDLISSGFPVSFTLGA EAILLALALGVLFGVIAALYHNKWQDYTVAILTIFGISVPSFIMAAVLQYVFSMKLGL FPVAGWDSWAYTFLPSIALASMPMAFIARLSRSSMIEVLNSDYIRTAKAKGLSRPAVT VRHAIRNALLPVVTYMGPMAAQVLTGSFIIETIFGIPGLGAHFVNSITNRDYTVIMGV TVFFSVILLLCVLIVDVLYGIIDPRIKLSKAKKGA*" gene 1221594..1222529 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" promotor_-10 complement(1221637..1221656) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1221654) /Source="Nicolas_upshifts" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1221672..1221678) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1222533..1223450 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 26782429" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 26782429; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389027.1" /db_xref="EnsemblGenomes-Gn:BSU11450" /db_xref="EnsemblGenomes-Tr:CAB13002" /db_xref="GOA:P24139" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10773" /db_xref="UniProtKB/Swiss-Prot:P24139" /translation="MQNIPKNMFEPAAANAGDAEKISKKSLSLWKDAMLRFRSNKLAM VGLIIIVLIILMAIFAPMFSRYDYSTTNLLNADKPPSKDHWFGTDDLGRDIFVRTWVG ARISIFIGVAAAVLDLLIGVIWGSISGFRGGRTDEIMMRIADILWAVPSLLMVILLMV VLPKGLFTIIIAMTITGWINMARIVRGQVLQLKNQEYVLASQTLGAKTSRLLFKHIVP NAMGSILVTMTLTVPTAIFTEAFLSYLGLGVPAPLASWGTMASDGLPALTYYPWRLFF PAGFICITMFGFNVVGDGLRDALDPKLRK*" gene 1222533..1223450 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" CDS 1223455..1224531 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 19202088, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 19202088, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389028.1" /db_xref="EnsemblGenomes-Gn:BSU11460" /db_xref="EnsemblGenomes-Tr:CAB13003" /db_xref="GOA:P24136" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10774" /db_xref="UniProtKB/Swiss-Prot:P24136" /translation="MIRVTRLLEVKDLAISFKTYGGEVQAIRGVNFHLDKGETLAIVG ESGSGKSVTSQAIMKLIPMPPGYFKRGEILFEGKDLVPLSEKEMQNVRGKEIGMIFQD PMTSLNPTMKVGKQITEVLFKHEKISKEAAKKRAVELLELVGIPMPEKRVNQFPHEFS GGMRQRVVIAMALAANPKLLIADEPTTALDVTIQAQILELMKDLQKKIDTSIIFITHD LGVVANVADRVAVMYAGQIVETGTVDEIFYDPRHPYTWGLLASMPTLESSGEEELTAI PGTPPDLTNPPKGDAFALRSSYAMKIDFEQEPPMFKVSDTHYVKSWLLHPDAPKVEPP EAVKAKMRKLANTFEKPVLVREVE*" gene 1223455..1224531 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" CDS 1224533..1225450 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 7997159, 11401703, 23133654, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 7997159, 11401703, 23133654, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389029.1" /db_xref="EnsemblGenomes-Gn:BSU11470" /db_xref="EnsemblGenomes-Tr:CAB13004" /db_xref="GOA:P24137" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10775" /db_xref="UniProtKB/Swiss-Prot:P24137" /translation="MTEKLLEIKHLKQHFVTPRGTVKAVDDLSFDIYKGETLGLVGES GCGKSTTGRSIIRLYEATDGEVLFNGENVHGRKSRKKLLEFNRKMQMIFQDPYASLNP RMTVADIIAEGLDIHKLAKTKKERMQRVHELLETVGLNKEHANRYPHEFSGGQRQRIG IARALAVDPEFIIADEPISALDVSIQAQVVNLMKELQKEKGLTYLFIAHDLSMVKYIS DRIGVMYFGKLVELAPADELYENPLHPYTKSLLSAIPLPDPDYERNRVRQKYDPSVHQ LKDGETMEFREVKPGHFVMCTEAEFKAFS*" gene 1224533..1225450 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" downshifts 1225420 /Source="Nicolas_upshifts" /id="D624" /incds=0 /nref=21 /ntot=196 /MaxReadThrough="1.58906" /MaxDrop="5.17491" /score="28.2861081" /energy="-15.2" /TU="NA" /idTUdmin="U920" /TUdmin="-8" /isTUend="TRUE" promotor_-35 1225500..1225503 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1225516 /Source="Nicolas_upshifts" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 1225518..1225537 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1225557..1226774 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563878, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_389030.2" /db_xref="EnsemblGenomes-Gn:BSU11480" /db_xref="EnsemblGenomes-Tr:CAB13005" /db_xref="GOA:O31600" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13131" /db_xref="UniProtKB/Swiss-Prot:O31600" /translation="MQFLHNKNVFALLLSQSFQSLAGVLVTIVLMVRIYQMTDSVFLA GLILSFMSFASIAASFCVSPVLRILGFKKVLAGANLLRAVFIILMAYSVTHHGQAFFW ITLLFVFCFSFAGAFFQPARFALLPIIVPKKQYVKANGVISLSNQLFLTAGWGLGGLL TYAVPFELVVGAAICLFVLSGASISVLHVNEEEAAGTAETASVRSIWKDLMIIPIVRD ITVMDMLEALAGSVWSSAILLAFTAAVLHETEVWWGMFNASYFIGAIVGSVIAIRFSS FFERNMGYAIMFSSLVMSALTLLFSFSPVPFLCALACAAMGPFYQVRDICQETMLQEV IPEQKRIGIMAAKNAILTPWSGVTYSIMGLVADAAGAKIAFIAAAALYIMTFLIALAQ PRLVHYRRENRVQ*" gene 1225557..1226774 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" promotor_-35 1226827..1226836 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-35" promotor_-10 1226849..1226864 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-10" S_feature 1226858..1226937 /Source="Nicolas_S_feature" /locus_tag="new_1226858_1226937" /HighExp="Etha, B60, M9-stat, T0.30H, Salt, T3.0H, T1.0H, T4.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S408" upshifts 1226858 /Source="Nicolas_upshifts" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" CDS 1226938..1227516 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17158660, 17158663, 21815947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol oxidation management factor; putative acetyltransferase" /protein_id="NP_389031.2" /db_xref="EnsemblGenomes-Gn:BSU11490" /db_xref="EnsemblGenomes-Tr:CAB13006" /db_xref="GOA:O31601" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13132" /db_xref="UniProtKB/Swiss-Prot:O31601" /translation="MNWYEKLSEYFPIEEMKSKAHMEALLKERSDIYHKDEGKHHILM FAEFDSFIFVDYLYVSKDARGQGLGGKLIAKLKKKNKPILLEVEPVDEDDTDTEKRLR FYQREHFKHAQSIGYRRRSLATNEVNKMEILYWSPKTESEEEILEAMKQTYENIHTYK DEKWYGESYEKTDEVLEIIDEEKQKNIFDQLS*" gene 1226938..1227516 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" S_feature 1227517..1227631 /Source="Nicolas_S_feature" /locus_tag="new_1227517_1227631" /HighExp="B60, Etha, Salt, T0.30H, M9-stat, LoTm, Gly, T1.0H, B36, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S409" promotor_-10 complement(1227568..1227587) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1227572) /Source="Nicolas_upshifts" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1227601..1227608) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1227634..1227647 /Source="Nicolas_upshift_promotors" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1227634 /Source="Nicolas_upshifts" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" CDS 1227697..1228092 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="redox-sensitive regulator" /protein_id="NP_389032.1" /db_xref="EnsemblGenomes-Gn:BSU11500" /db_xref="EnsemblGenomes-Tr:CAB13007" /db_xref="GOA:O31602" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR023731" /db_xref="InterPro:IPR036249" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG13133" /db_xref="UniProtKB/Swiss-Prot:O31602" /translation="MVTLYTSPSCTSCRKARAWLEEHEIPFVERNIFSEPLSIDEIKQ ILRMTEDGTDEIISTRSKVFQKLNVNVESMPLQDLYRLINEHPGLLRRPIIIDEKRLQ VGYNEDEIRRFLPRKVRSFQLREAQRLAN*" gene 1227697..1228092 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" promotor_no_box complement(1227928..1228028) /Source="Nicolas_upshift_promotors" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1227968) /Source="Nicolas_upshifts" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1228090 /Source="Nicolas_upshifts" /id="D625" /incds=0 /nref=263 /ntot=269 /MaxReadThrough="4.34531" /MaxDrop="8.0579" /score="7.42972561" /energy="-8.8" /TU="U923" /idTUdmin="U925" /TUdmin=0 /isTUend="TRUE" S_feature 1228135..1228924 /Source="Nicolas_S_feature" /locus_tag="new_1228135_1228924" /HighExp="B60, B36, Etha, M9-stat, Salt, H2O2, Paraq, Cold, G180, G135" /AntisenseName="yjbE" /AntisenseCor="-0.18634010398760401" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S410" CDS complement(1228135..1228791) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389033.1" /db_xref="EnsemblGenomes-Gn:BSU11510" /db_xref="EnsemblGenomes-Tr:CAB13008" /db_xref="GOA:O31603" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022301" /db_xref="SubtiList:BG13134" /db_xref="UniProtKB/Swiss-Prot:O31603" /translation="MEHDYLISLLVIVGIDLILGGDNAVVIAMASRHLPDKQRQQAII LGTFIAVAMRIGLTSAAVYLLNIPFLQCAGGIFLLYLGYQLLIEKKDTKHIKSSTSLW RAIRTIVLADLFMSLDNVIAVAGASHGEFSLVVIGLCVSVPVIIWGSKLIHIALEKIP LLIYAGSGLLAYTGGEMIVRDKKLSLFMAQHGTVETLLPILTVAFVILASIYYQQVEK *" gene complement(1228135..1228791) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" promotor_-10 complement(1228821..1228839) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1228836) /Source="Nicolas_upshifts" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" promotor_-35 complement(1228854..1228859) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1228897..1228904 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1228918..1228937 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1228926..1229067 /Source="Nicolas_S_feature" /locus_tag="new_1228926_1229067" /HighExp="B60, Diami, Etha, dia5, LPhT, M9-stat, T5.0H, T3.0H, dia15, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S411" upshifts 1228926 /Source="Nicolas_upshifts" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" CDS 1228961..1229101 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513949.1" /translation="MVKVKMWTEWVKCSKVQLIGSLDVPSTSYIEGKVGKWKLKELTS IQ*" gene 1228961..1229101 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" CDS 1229068..1229724 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10361283, 10447896, 16525504, 19801546, 21435029, 23595989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 10447896, 16525504, 19801546, 21435029, 23595989; Product type f : factor" /codon_start=1 /transl_table=11 /product="adaptor protein controlling oligomerization of the AAA+ protein ClpC" /protein_id="NP_389034.1" /db_xref="EnsemblGenomes-Gn:BSU11520" /db_xref="EnsemblGenomes-Tr:CAB13009" /db_xref="GOA:P37958" /db_xref="InterPro:IPR008681" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3JTP" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="SubtiList:BG10680" /db_xref="UniProtKB/Swiss-Prot:P37958" /translation="MEIERINEHTVKFYMSYGDIEDRGFDREEIWYNRERSEELFWEV MDEVHEEEEFAVEGPLWIQVQALDKGLEIIVTKAQLSKDGQKLELPIPEDKKQEPASE DLDALLDDFQKEEQAVNQEEKEQKLQFVLRFGDFEDVISLSKLNVNGSKTTLYSFENR YYLYVDFCNMTDEEVENQLSILLEYATESSISIHRLEEYGKLIISEHALETIKKHFAS *" gene 1229068..1229724 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" downshifts 1229714 /Source="Nicolas_upshifts" /id="D626" /incds=0 /nref=120 /ntot=308 /MaxReadThrough="5.41786" /MaxDrop="7.67172" /score="32.2431225" /energy="-11.8" /TU="U928" /idTUdmin="U928" /TUdmin="-774" /isTUend="FALSE" CDS complement(1229719..1229841) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513950.1" /translation="MINSCSLYFLLVYMFLIFHISKMAFSCIKKTDFRKEIGLL*" gene complement(1229719..1229841) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" S_feature 1229759..1229848 /Source="Nicolas_S_feature" /locus_tag="new_1229759_1229848" /HighExp="Etha, M9-stat, B60, dia15, T0.30H, Diami, C30, H2O2, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S412" promotor_-35 1229827..1229835 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1229846..1229864 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1229850..1229914 /Source="Nicolas_S_feature" /locus_tag="new_1229850_1229914" /HighExp="Etha, G/S, GM 150, T-4.40H, S2, T-2.40H, Pyr, C90, M9-tran, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.876, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S413" upshifts 1229850 /Source="Nicolas_upshifts" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" CDS 1229915..1231036 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10438773, 17630974, 23046409, 26880300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438773, 17630974, 23046409, 26880300; Product type s: structure" /codon_start=1 /transl_table=11 /product="protein involved in establishment of DNA transport in competence" /protein_id="NP_389035.1" /db_xref="EnsemblGenomes-Gn:BSU11530" /db_xref="EnsemblGenomes-Tr:CAB13010" /db_xref="GOA:O31604" /db_xref="InterPro:IPR010330" /db_xref="InterPro:IPR021176" /db_xref="SubtiList:BG13135" /db_xref="UniProtKB/Swiss-Prot:O31604" /translation="MFHLLGAQQNQKLKRRRFFCPVCGGELAVKLGLQKAPHFAHKQN KSCAIDIEPESAYHLEGKRQLYVWLKTQRASPILEPYIRTINQRPDVMARIKEHMLAV EYQCATIAPDVFQKRTEGFKQEGIIPQWIMGYSRLKRTASSFYQLSTFHWQFINASPY RELICYCPERRSFLRLSHIIPFYTNHSYSSVQTIPIHRAGAGDLFFTEPKPSIQYSGW TKAIHRFRHKPHRFNSKETNRLRLLFYEKRQTPFSFLPTEVFVPVRKGAVFKSPVFVW QGFLYLFMTDLGGKRAPIRFSAVLQQCKLHIHNKNIALRSECSEECLSEAVKQYIDFL CKKGFLRETQKEVYVLNQPAGGIHSMQDLIERDRSCFIE*" gene 1229915..1231036 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" promotor_-35 1230690..1230696 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" upshifts 1230708 /Source="Nicolas_upshifts" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" promotor_-10 1230711..1230729 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" promotor_-35 1230922..1230930 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" promotor_-10 1230942..1230960 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" upshifts 1230949 /Source="Nicolas_upshifts" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" promotor_-35 1231030..1231036 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1231051..1231062 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1231060 /Source="Nicolas_upshifts" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" CDS 1231083..1233095 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11741842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11741842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoendopeptidase F" /protein_id="NP_389036.2" /db_xref="EnsemblGenomes-Gn:BSU11540" /db_xref="EnsemblGenomes-Tr:CAB13011" /db_xref="GOA:O31605" /db_xref="InterPro:IPR001567" /db_xref="InterPro:IPR004438" /db_xref="InterPro:IPR013647" /db_xref="SubtiList:BG13136" /db_xref="UniProtKB/Swiss-Prot:O31605" /translation="MKGTKGKVFRVFTAFLAFVLFITAYDLTKGSEKPEDIHNTSLLR NSCFFNWLESKKTRGITMAEEKKANQLPDRSEVKAEDTWRLEDIFPSDEAWNKEFQAV KELIPNLSKYKGKLADSADHLYEALTYQDKVMERLGRLYTYAHMRSDQDTGNSFYQGL NDKAGNLYTQAASATAYLVPEILSIEEDKLQQFILEKEELKLYSHAIEEITKERPHVL SEKEEALLAEASEVLGSSSNTFSVLNNADITFPSIKDEDGNEKQITHGNFINFLESEN REVRKNAFDAVYKTYGQYKNTMATTLSGTVKKDNFYARVKKYKSAREAALSNNSIPEE VYDNLVKTINKHLPLLHRYIALRKKVLELDEVHIYDLYTPLVKDAGMKVTYEEAKDYM LKGLAPLGEEYASILKEGLENRWVDVYENKGKRNGAYSSGAYGTNPYILMNWHNNVNN LFTLVHEFGHSVHSYYTRKHQPYPYGNYSIFVAEVASTTNEALLGEYLLNNLEDEKQR LYILNHMLEGFRGTVFRQTMFAEFEHLIHTKAQEGEPLTPELLTNVYYDLNKKYFGDG MVIDKEIGLEWSRIPHFYYNYYVYQYATGYSAAQALSSQILKEGKPAVDRYIDFLKAG SSQYPIDVLKKAGVDMTSPEPIEAACKMFEEKLDEMEELLMKVKQS*" gene 1231083..1233095 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" promotor_-35 1231158..1231165 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-35" promotor_-10 1231180..1231199 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-10" upshifts 1231192 /Source="Nicolas_upshifts" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" downshifts 1233042 /Source="Nicolas_upshifts" /id="D627" /incds=0 /nref=98 /ntot=339 /MaxReadThrough="4.70576" /MaxDrop="5.74441" /score="19.0969124" /energy="-15.2" /TU="U933" /idTUdmin="U931" /TUdmin=2 /isTUend="TRUE" S_feature 1233096..1233397 /Source="Nicolas_S_feature" /locus_tag="new_1233096_1233397" /HighExp="Etha, dia15, Diami, B60, M9-stat, S8, M0t90, dia5, B36, T0.30H" /AntisenseName="yizD" /AntisenseCor="-1.29003203536192E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="SigH, SigB" /TUlongPSig="0.999, 0.999" /label="S414" CDS complement(1233133..1233300) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097703.1" /db_xref="EnsemblGenomes-Gn:BSU11549" /db_xref="EnsemblGenomes-Tr:CAX52593" /db_xref="GOA:C0H3Y6" /db_xref="UniProtKB/Swiss-Prot:C0H3Y6" /translation="MMSTLISIVCIAVFFCLNILGMMHMLPLYITSPLLFLSILFTLY RLNHRKTFKGF*" gene complement(1233133..1233300) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" downshifts complement(1233146) /Source="Nicolas_upshifts" /id="D628" /incds=0 /nref=8 /ntot=61 /MaxReadThrough="1.527" /MaxDrop="5.54041" /score="-4.56163992" /energy="-15.2" /TU="NA" /idTUdmin="U934" /TUdmin="-8" /isTUend="TRUE" promotor_-10 complement(1233320..1233338) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1233336) /Source="Nicolas_upshifts" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" promotor_-35 complement(1233354..1233359) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1233390..1233397 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1233399..1233524 /Source="Nicolas_S_feature" /locus_tag="new_1233399_1233524" /HighExp="B36, T-1.10H, nit, T-0.40H, M9-tran, LoTm, Pyr, Etha, Salt, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.883" /TUlongSig="SigA, SigH, SigB" /TUlongPSig="0.926, 0.999, 0.999" /label="S415" upshifts 1233399 /Source="Nicolas_upshifts" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" misc_RNA 1233405..1233543 /gene="roxS" /locus_tag="BSU_misc_RNA_67" /product="small regulatory RNA (NO regulated)" /experiment="publication(s) with functional evidences, PMID:19682248, 19786493, 20511587, 20525796, 25643072, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682248, 19786493, 20511587, 20525796, 25643072, 28436820; Product type n : RNA" gene 1233405..1233543 /gene="roxS" /locus_tag="BSU_misc_RNA_67" promotor_-10 1233412..1233431 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1233481 /Source="Nicolas_upshifts" /id="D629" /incds=0 /nref=96 /ntot=135 /MaxReadThrough="3.50613" /MaxDrop="9.07209" /score="5.30186633" /energy="-11.6" /TU="U935" /idTUdmin="U933" /TUdmin=89 /isTUend="FALSE" CDS complement(1233614..1234513) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiol management effector of SpxA degradation" /protein_id="NP_389037.2" /db_xref="EnsemblGenomes-Gn:BSU11550" /db_xref="EnsemblGenomes-Tr:CAB13012" /db_xref="GOA:O31606" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13137" /db_xref="UniProtKB/Swiss-Prot:O31606" /translation="MTNYQHELYFAHCHGHPKKPLEIYMFVDPLCPECWSLEPVIKKL KIRYGRFFTLRIIASASLTALNKKRKKHLLAEAWEKIASRSGMSCDGNVWFEQDQPLS SPYMAALAFKAAELQGRKAGMQFLRNMQESLFVSKKNITDENVLLEIAENTSLDLEEF KKDLHSQSAVKALQCDMKIAAEMDVSVNPTLTFFNTQHEDEGLKVPGSYSYDVYEEIL FEMLGDEPKPSETPPLECFIEYFRFVASKEIALVYDLSLEEVEKEMKKLAFAKKVAKV EAKHGMFWKSLSTYSDEYQSCEK*" gene complement(1233614..1234513) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" downshifts complement(1233645) /Source="Nicolas_upshifts" /id="D630" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="3.70729" /MaxDrop="5.65601" /score="17.9327625" /energy="-13.3" /TU="U937" /idTUdmin="U937" /TUdmin="-89" /isTUend="FALSE" promotor_-35 1233849..1233854 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1233861 /Source="Nicolas_upshifts" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" promotor_-10 1233870..1233888 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1233877..1235778 /Source="Nicolas_S_feature" /locus_tag="new_1233877_1235778" /HighExp="S6, S4, S5, S8, S3, S7, BT, B36, C30, T5.0H" /AntisenseName="yjbH" /AntisenseCor="-0.61019541931037402" /AntisenseRegPval="-28.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S416" CDS complement(1234510..1234908) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15866723, 17293416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol management oxidoreductase component" /protein_id="NP_389038.1" /db_xref="EnsemblGenomes-Gn:BSU11560" /db_xref="EnsemblGenomes-Tr:CAB13013" /db_xref="GOA:O31607" /db_xref="InterPro:IPR001486" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR019795" /db_xref="PDB:1UX8" /db_xref="SubtiList:BG13138" /db_xref="UniProtKB/Swiss-Prot:O31607" /translation="MGQSFNAPYEAIGEELLSQLVDTFYERVASHPLLKPIFPSDLTE TARKQKQFLTQYLGGPPLYTEEHGHPMLRARHLPFPITNERADAWLSCMKDAMDHVGL EGEIREFLFGRLELTARHMVNQTEAEDRSS*" gene complement(1234510..1234908) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" S_feature complement(1234909..1235088) /Source="Nicolas_S_feature" /locus_tag="new_1234909_1235088_c" /HighExp="Diami, dia5, dia15, Etha, H2O2, C90, LoTm, Heat, Salt, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.999" /label="S417" promotor_-10 complement(1235080..1235099) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1235088) /Source="Nicolas_upshifts" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" promotor_-35 complement(1235111..1235118) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1235163..1235708) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" /EC_number="3.2.1.-" /EC_number="3.2.1.17" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:20609359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20609359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional muramidase and murein lytic transglycosylase" /protein_id="NP_389039.1" /db_xref="EnsemblGenomes-Gn:BSU11570" /db_xref="EnsemblGenomes-Tr:CAB13014" /db_xref="GOA:O31608" /db_xref="InterPro:IPR000189" /db_xref="InterPro:IPR008258" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13139" /db_xref="UniProtKB/Swiss-Prot:O31608" /translation="MLNSANTTAPSLLSAYGLNSYTSSNSGSVTKAAESTETAVADSA SNKHEANQIRSGDFSIDSAIKKAADKYGVDEKLIRAVIKQESGFNAKAVSGAGAMGLM QLMPSTASSLGVSNPLDPQQNVEGGTKYLKQMLDKYDGNVSMALAAYNAGPGNVDRYG GIPPFQETQNYVKKITSVYYA*" gene complement(1235163..1235708) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" downshifts complement(1235187) /Source="Nicolas_upshifts" /id="D631" /incds=0 /nref=101 /ntot=222 /MaxReadThrough="4.1014" /MaxDrop="5.00847" /score="6.97790581" /energy="-9.1" /TU="U938,U939" /idTUdmin="U938" /TUdmin="-90" /isTUend="FALSE" S_feature complement(1235709..1235911) /Source="Nicolas_S_feature" /locus_tag="new_1235709_1235911_c" /HighExp="T0.30H, Gly, C90, GM 10, GM 45, M0t90, Lbstat, C30, Lbtran, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S418" CDS complement(1235912..1236484) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9642185, 12456267, 16905149, 20509597, 26904951, 27881678; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative RNA/thiamine triphosphatase" /protein_id="NP_389040.1" /db_xref="EnsemblGenomes-Gn:BSU11580" /db_xref="EnsemblGenomes-Tr:CAB13015" /db_xref="GOA:O31609" /db_xref="InterPro:IPR009195" /db_xref="InterPro:IPR023577" /db_xref="InterPro:IPR033469" /db_xref="SubtiList:BG13140" /db_xref="UniProtKB/Swiss-Prot:O31609" /translation="MSQEIEIEFKNMLTKQEFKNIASALQLTEKDFTDQKNHYFDTDS FALKQKHAALRIRRKNGKYVLTLKEPADVGLLETHQQLSEVSDLAGFSVPEGPVKDQL HKLQIDTDAIQYFGSLATNRAEKETEKGLIVLDHSRYLNKEDYEIEFEAADWHEGRQA FEKLLQQFSIPQRETKNKILRFYEEKRKSI*" gene complement(1235912..1236484) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" promotor_-10 complement(1236057..1236075) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1236066) /Source="Nicolas_upshifts" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" promotor_-35 complement(1236088..1236095) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" promotor_-10 complement(1236513..1236532) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1236530) /Source="Nicolas_upshifts" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" promotor_-35 1236546..1236549 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1236547..1236554) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" upshifts 1236562 /Source="Nicolas_upshifts" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" promotor_-10 1236565..1236584 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1236609..1236977 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389041.1" /db_xref="EnsemblGenomes-Gn:BSU11590" /db_xref="EnsemblGenomes-Tr:CAB13016" /db_xref="InterPro:IPR020908" /db_xref="SubtiList:BG13141" /db_xref="UniProtKB/Swiss-Prot:O31610" /translation="MQNRIEILNATLSDDQLRLACQTEGNEAERKPSGQMLVDSDHFA FVYILELADSFEYVIIKEHVWPELKQAHAQKIPVVLEAGDQTIELAGLHEELEYLLEN IKDNANYGEEMEEKVKRVFL*" gene 1236609..1236977 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" CDS 1237006..1237641 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" /EC_number="2.7.6.5" /function="16.1: Circulate" /function="16.14: Store" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 24163341, 25331430, 26825398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 24163341, 25331430, 26825398; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_389042.1" /db_xref="EnsemblGenomes-Gn:BSU11600" /db_xref="EnsemblGenomes-Tr:CAB13017" /db_xref="GOA:O31611" /db_xref="InterPro:IPR007685" /db_xref="PDB:5DEC" /db_xref="PDB:5DED" /db_xref="PDB:5F2V" /db_xref="SubtiList:BG13142" /db_xref="UniProtKB/Swiss-Prot:O31611" /translation="MDDKQWERFLVPYRQAVEELKVKLKGIRTLYEYEDDHSPIEFVT GRVKPVASILEKARRKSIPLHEIETMQDIAGLRIMCQFVDDIQIVKEMLFARKDFTVV DQRDYIAEHKESGYRSYHLVVLYPLQTVSGEKHVLVEIQIRTLAMNFWATIEHSLNYK YSGNIPEKVKLRLQRASEAASRLDEEMSEIRGEVQEAQAAFSRKKKGSEQQ*" gene 1237006..1237641 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" CDS 1237660..1238460 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" /EC_number="2.7.1.23" /function="16.14: Store" /function="16.7: Manage energy" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12897004, 16233726, 16511117, 18720024, 24048943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12897004, 16233726, 16511117, 18720024, 24048943; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase (quinolate activated)" /protein_id="NP_389043.1" /db_xref="EnsemblGenomes-Gn:BSU11610" /db_xref="EnsemblGenomes-Tr:CAB13018" /db_xref="GOA:O31612" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13143" /db_xref="UniProtKB/Swiss-Prot:O31612" /translation="MKFAVSSKGDQVSDTLKSKIQAYLLDFDMELDENEPEIVISVGG DGTLLYAFHRYSDRLDKTAFVGVHTGHLGFYADWVPHEIEKLVLAIAKTPYHTVEYPL LEVIVTYHENEREERYLALNECTIKSIEGSLVADVEIKGQLFETFRGDGLCLSTPSGS TAYNKALGGAIIHPSIRAIQLAEMASINNRVFRTVGSPLLLPSHHDCMIKPRNEVDFQ VTIDHLTLLHKDVKSIRCQVASEKVRFARFRPFPFWKRVQDSFIGKGE*" gene 1237660..1238460 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" CDS 1238523..1239374 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" /EC_number="5.4.99.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389044.1" /db_xref="EnsemblGenomes-Gn:BSU11620" /db_xref="EnsemblGenomes-Tr:CAB13019" /db_xref="GOA:O31613" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG13144" /db_xref="UniProtKB/Swiss-Prot:O31613" /translation="MTVKEYAGELGISKRLLTDIKFGGGDLQINGEHVTVKYVLKEGD LLIVKFPEEQVSETLLAEPVPLDILYEDEHVLVINKQPYVSSIPSREHPSGSIANGII DHYQTTGVRATVHLVTRLDRDTSGIMLVAKHRFAHSILSSAQKNGLVKRRYAAVVHGR MAQMEGTVDAPIGRHPDSIIERTVTPDGQKAVTHFYVTCANDDMTSVALQLETGRTHQ IRVHMSYLGHPLCGDTLYGGTRQEIGRQALHSEHLSFIHPLTQENMRFHAPLPQDMSK LIKGENH*" gene 1238523..1239374 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" downshifts 1239333 /Source="Nicolas_upshifts" /id="D632" /incds=0 /nref=203 /ntot=256 /MaxReadThrough="0.25796" /MaxDrop="5.73002" /score="21.4914497" /energy="-12.8" /TU="NA" /idTUdmin="U940" /TUdmin=0 /isTUend="TRUE" CDS complement(1239387..1240121) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" /EC_number="3.6.1.17" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12059787, 16740944, 21092197, 23824080, 28516732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12059787, 16740944, 21092197, 23824080, 28516732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphorylated protein phosphatase E and diadenosine-polyphosphate hydrolase" /protein_id="NP_389045.1" /db_xref="EnsemblGenomes-Gn:BSU11630" /db_xref="EnsemblGenomes-Tr:CAB13020" /db_xref="GOA:O31614" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR023937" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13145" /db_xref="UniProtKB/Swiss-Prot:O31614" /translation="MAYDIISDIHGCYDEMTALIQKLGYTIKNGVPVHEEGRVLVFAG DLTDRGPKSIEVIRFVAGAYEKGAVRYVPGNHCNKLYRYLKGNPVKVMHGLETTAAEL EELSKDEKKSVSEQFMKLYETAPLYDILHNGELVVAHAGIRADDIGKYTRRVKDFVLY GDVTGETYPDGRPIRRDWAAAYNGKAWVVYGHTPVKEPRKVNRTINIDTGCVFGNQLT GFRFPEIETVSVPSSLPYDESRFRPI*" gene complement(1239387..1240121) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" downshifts complement(1239409) /Source="Nicolas_upshifts" /id="D633" /incds=0 /nref=22 /ntot=152 /MaxReadThrough="1.18091" /MaxDrop="3.57735" /score="3.24324561" /energy="-12.8" /TU="NA" /idTUdmin="U938" /TUdmin="-4312" /isTUend="FALSE" promotor_-35 1240243..1240247 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-35" promotor_-10 1240264..1240283 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-10" upshifts 1240278 /Source="Nicolas_upshifts" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" S_feature 1240279..1240355 /Source="Nicolas_S_feature" /locus_tag="new_1240279_1240355" /HighExp="H2O2, Diami, dia15, Paraq, Oxctl, Heat, G180, Salt, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S419" CDS 1240356..1242200 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 21742892, 24330391; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gated K+/H+ antiporter" /protein_id="NP_389046.1" /db_xref="EnsemblGenomes-Gn:BSU11640" /db_xref="EnsemblGenomes-Tr:CAB13021" /db_xref="GOA:O31615" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13146" /db_xref="UniProtKB/Swiss-Prot:O31615" /translation="MAHTSVASLVVVLIVAFLTPILLHRFKLSIPVVVAEIIMGLIIG KSGLNLVVEGDTWLQTLSMLGFIFLMFLSGLEIDFSSFEKGKKKQFLPNGKEAPNTFA AASVIFVGIFILSLLLSYGFVLAGFIQNAFLMTLIISTISLGVVVPTLKEERIMNSNI GQIILLVAVIADLATMILLAVFSSLYGEDSGNMWLLMILFAAGVVLYFFGRVFKHRSF VQSMSKGTIQIGTRAIFTLIIVLVALSESLGAENILGAFLAGVLVSLLSPNKELVQQL DSFGYGFLIPIFFVMVGVKLDIWTLFQDKTILIMIPLLLLALLVSKIIPVMYLKKWYD NRTIFASGFLLTSTLSLVIAAATIGQQLHVISTNMSGALILVAVIASIFTPICFKKLY KREEQPEEKKTITFIGANQMTLPVTLELPEEEYDVRVVHVYQENAEEKLSESVFAVET ISDYEHETLESLGIFETDILVVATGNEDMNADIALLAKDKGTERVIASVGSPEHEAAL KEQGISIFSILLSTKTLLRALIEAPGVMKLLTNQESSLYQINMENSKYDGVILREFPL TGDVIFVRIFRGVDSIVPHGDTRLKLGDRLIVTGSRGYVTDLKKTLEG*" gene 1240356..1242200 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" misc_feature complement(1240683..1240702) /Source="Nicolas_upshift_promotors" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1240707) /Source="Nicolas_upshifts" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 1242202..1242209 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-35" promotor_-10 1242223..1242242 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-10" upshifts 1242229 /Source="Nicolas_upshifts" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" misc_RNA 1242262..1242370 /gene="tswA" /locus_tag="BSU_misc_RNA_14" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" gene 1242262..1242370 /gene="tswA" /locus_tag="BSU_misc_RNA_14" downshifts 1242365 /Source="Nicolas_upshifts" /id="D634" /incds=0 /nref=20 /ntot=84 /MaxReadThrough="7.67021" /MaxDrop="5.27759" /score="34.8346124" /energy="-12.5" /TU="U943" /idTUdmin="U941" /TUdmin="-4" /isTUend="TRUE" CDS 1242449..1243159 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" /EC_number="3.5.99.2" /function="4.11: Thiamine" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 17618314, 18054064, 24311574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 17618314, 18054064, 24311574; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiaminase II" /protein_id="NP_389047.1" /db_xref="EnsemblGenomes-Gn:BSU11650" /db_xref="EnsemblGenomes-Tr:CAB13022" /db_xref="GOA:P25052" /db_xref="InterPro:IPR004305" /db_xref="InterPro:IPR016084" /db_xref="InterPro:IPR027574" /db_xref="PDB:1TO9" /db_xref="PDB:1TYH" /db_xref="PDB:1YAF" /db_xref="PDB:1YAK" /db_xref="PDB:2QCX" /db_xref="SubtiList:BG10791" /db_xref="UniProtKB/Swiss-Prot:P25052" /translation="MKFSEECRSAAAEWWEGSFVHPFVQGIGDGTLPIDRFKYYVLQD SYYLTHFAKVQSFGAAYAKDLYTTGRMASHAQGTYEAEMALHREFAELLEISEEERKA FKPSPTAYSYTSHMYRSVLSGNFAEILAALLPCYWLYYEVGEKLLHCDPGHPIYQKWI GTYGGDWFRQQVEEQINRFDELAENSTEEVRAKMKENFVISSYYEYQFWGMAYRKEGW SDSAIKEVEECGASRHNG*" gene 1242449..1243159 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" CDS 1243134..1243751 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" /EC_number="5.3.99.10" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 21534620" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 21534620; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiazole tautomerase" /protein_id="NP_389048.1" /db_xref="EnsemblGenomes-Gn:BSU11660" /db_xref="EnsemblGenomes-Tr:CAB13023" /db_xref="GOA:P25053" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR036206" /db_xref="PDB:1YAD" /db_xref="PDB:3QH2" /db_xref="SubtiList:BG10792" /db_xref="UniProtKB/Swiss-Prot:P25053" /translation="MELHAITDDSKPVEELARIIITIQNEVDFIHIRERSKSAADILK LLDLIFEGGIDKRKLVMNGRVDIALFSTIHRVQLPSGSFSPKQIRARFPHLHIGRSVH SLEEAVQAEKEDADYVLFGHVFETDCKKGLEGRGVSLLSDIKQRISIPVIAIGGMTPD RLRDVKQAGADGIAVMSGIFSSAEPLEAARRYSRKLKEMRYEKAL*" gene 1243134..1243751 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" CDS 1243735..1244844 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" /EC_number="1.4.3.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9827558, 11744710, 12627963, 15105420, 19751796, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9827558, 11744710, 12627963, 15105420, 19751796, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="FAD-dependent glycine oxidase" /protein_id="NP_389049.1" /db_xref="EnsemblGenomes-Gn:BSU11670" /db_xref="EnsemblGenomes-Tr:CAB13024" /db_xref="GOA:O31616" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR012727" /db_xref="InterPro:IPR036188" /db_xref="PDB:1NG3" /db_xref="PDB:1NG4" /db_xref="PDB:1RYI" /db_xref="PDB:3IF9" /db_xref="SubtiList:BG13147" /db_xref="UniProtKB/Swiss-Prot:O31616" /translation="MKRHYEAVVIGGGIIGSAIAYYLAKENKNTALFESGTMGGRTTS AAAGMLGAHAECEERDAFFDFAMHSQRLYKGLGEELYALSGVDIRQHNGGMFKLAFSE EDVLQLRQMDDLDSVSWYSKEEVLEKEPYASGDIFGASFIQDDVHVEPYFVCKAYVKA AKMLGAEIFEHTPVLHVERDGEALFIKTPSGDVWANHVVVASGVWSGMFFKQLGLNNA FLPVKGECLSVWNDDIPLTKTLYHDHCYIVPRKSGRLVVGATMKPGDWSETPDLGGLE SVMKKAKTMLPAIQNMKVDRFWAGLRPGTKDGKPYIGRHPEDSRILFAAGHFRNGILL APATGALISDLIMNKEVNQDWLHAFRIDRKEAVQI*" gene 1243735..1244844 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" CDS 1244844..1245044 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 14567704, 14757766, 15489164, 22616866, 26443755; Product type c : carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier for synthesis of hydroxyethylthiazole phosphate" /protein_id="NP_389050.1" /db_xref="EnsemblGenomes-Gn:BSU11680" /db_xref="EnsemblGenomes-Tr:CAB13025" /db_xref="GOA:O31617" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010035" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="PDB:1TYG" /db_xref="SubtiList:BG13148" /db_xref="UniProtKB/Swiss-Prot:O31617" /translation="MLQLNGKDVKWKKDTGTIQDLLASYQLENKIVIVERNKEIIGKE RYHEVELCDRDVIEIVHFVGGG*" gene 1244844..1245044 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" CDS 1245041..1245811 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" /EC_number="2.8.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14567704, 14757766, 15489164, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14567704, 14757766, 15489164, 22938038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="hydroxyethylthiazole phosphate synthetase (thiamine biosynthesis)" /protein_id="NP_389051.1" /db_xref="EnsemblGenomes-Gn:BSU11690" /db_xref="EnsemblGenomes-Tr:CAB13026" /db_xref="GOA:O31618" /db_xref="InterPro:IPR008867" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033983" /db_xref="PDB:1TYG" /db_xref="PDB:1XM3" /db_xref="SubtiList:BG13149" /db_xref="UniProtKB/Swiss-Prot:O31618" /translation="MSMLTIGGKSFQSRLLLGTGKYPSFDIQKEAVAVSESDILTFAV RRMNIFEASQPNFLEQLDLSKYTLLPNTAGASTAEEAVRIARLAKASGLCDMIKVEVI GCSRSLLPDPVETLKASEQLLEEGFIVLPYTSDDVVLARKLEELGVHAIMPGASPIGS GQGILNPLNLSFIIEQAKVPVIVDAGIGSPKDAAYAMELGADGVLLNTAVSGADDPVK MARAMKLAVEAGRLSYEAGRIPLKQYGTASSPGEGLPV*" gene 1245041..1245811 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" CDS 1245808..1246818 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" /EC_number="2.7.7.73" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14567704, 14757766, 15489164, 16388576, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14567704, 14757766, 15489164, 16388576, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate transferase and sulfur transferase (thiamine biosynthesis)" /protein_id="NP_389052.1" /db_xref="EnsemblGenomes-Gn:BSU11700" /db_xref="EnsemblGenomes-Tr:CAB13027" /db_xref="GOA:O31619" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13150" /db_xref="UniProtKB/Swiss-Prot:O31619" /translation="MTGRYSRQELFAPIGPSGQKKLKEARAVIIGAGALGTASAEMLV RAGVGSVKIADRDYVEWSNLQRQQLYTEDDVKKEMPKAAAAERRLRSINSDVDVTGLV MDVTAENIFELIRDASIIVDAADNFETRLIVNDAAVKEGIPFLYGACVGSYGLTFTVV PGSTPCLHCLLDALPIGGATCDTAGIISPAVLQVAVFQVTDALKLLTGEECEPVLRSF DLWKNERSEVRAASLKHDACPSCGTKDFPFLSYENQTKAAVLCGRNTVQIRSSITKEA DLEALAGQLRQAGLEVAANPYLISCRSDDMKMVLFRDGRALIHGTNDIARAKSIYHKW IG*" gene 1245808..1246818 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" CDS 1246837..1247652 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" /EC_number="2.7.4.7" /EC_number="2.7.1.49" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14973012, 16952958, 17012797, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14973012, 16952958, 17012797, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine kinase, 4-amino-5-hydroxymethyl-2-methylpyrimidine and 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate kinase" /protein_id="NP_389053.1" /db_xref="EnsemblGenomes-Gn:BSU11710" /db_xref="EnsemblGenomes-Tr:CAB13028" /db_xref="GOA:O31620" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13151" /db_xref="UniProtKB/Swiss-Prot:O31620" /translation="MSIYKALTIAGSDSGGGAGIQADIKTFQELDVFGMSAITAVTAQ NTLGVHGVHPLTVETLRQQIDAVAEDLRPDAVKTGMLWNADMIEEVARKIDEYGFNRV IVDPVMIAKGGASLLRDESVATLKELLIPRSYAITPNVPEAETLTGMTISSLDDRKKA AEQLVKMGAQHVIIKGGHQPEDNHITDLLFDGSMFMQITHPYINTKHTHGTGCTFAAA LTAQTAKGDSIHQAFEVAANFVREAVENTLGIGSGHGPTNHFAFKRNSLNTSR*" gene 1246837..1247652 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" downshifts 1247626 /Source="Nicolas_upshifts" /id="D635" /incds=0 /nref=128 /ntot=172 /MaxReadThrough="3.33485" /MaxDrop="5.0154" /score="3.40314581" /energy="-14.8" /TU="U943" /idTUdmin="U943" /TUdmin="-89" /isTUend="FALSE" promotor_-35 1247699..1247705 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1247718..1247737 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1247728 /Source="Nicolas_upshifts" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" CDS 1247788..1248564 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" /EC_number="1.3.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 15105103, 21185310, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 15105103, 21185310, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase" /protein_id="NP_389054.2" /db_xref="EnsemblGenomes-Gn:BSU11720" /db_xref="EnsemblGenomes-Tr:CAB13029" /db_xref="GOA:P54616" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR014358" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIF" /db_xref="PDB:3OIG" /db_xref="SubtiList:BG13152" /db_xref="UniProtKB/Swiss-Prot:P54616" /translation="MNFSLEGRNIVVMGVANKRSIAWGIARSLHEAGARLIFTYAGER LEKSVHELAGTLDRNDSIILPCDVTNDAEIETCFASIKEQVGVIHGIAHCIAFANKEE LVGEYLNTNRDGFLLAHNISSYSLTAVVKAARPMMTEGGSIVTLTYLGGELVMPNYNV MGVAKASLDASVKYLAADLGKENIRVNSISAGPIRTLSAKGISDFNSILKDIEERAPL RRTTTPEEVGDTAAFLFSDMSRGITGENLHVDSGFHITAR*" gene 1247788..1248564 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" downshifts 1248553 /Source="Nicolas_upshifts" /id="D636" /incds=0 /nref=229 /ntot=313 /MaxReadThrough="3.12901" /MaxDrop="6.64182" /score="33.5478109" /energy="-11.8" /TU="U944" /idTUdmin="U944" /TUdmin="-416" /isTUend="FALSE" promotor_-35 1248612..1248617 /Source="Nicolas_upshift_promotors" /id="U945" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=1095 /SigmaFactorBS="tcaagcaatcccgaatagggattgcttttttatttCTTCTGa ttttcagctttctgTCATATAGATAGAATATGAcacaatcggagggatgaagatgtct a" /listShort="cotO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1248633..1248651 /Source="Nicolas_upshift_promotors" /id="U945" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=1095 /SigmaFactorBS="tcaagcaatcccgaatagggattgcttttttatttCTTCTGa ttttcagctttctgTCATATAGATAGAATATGAcacaatcggagggatgaagatgtct a" /listShort="cotO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1248637 /Source="Nicolas_upshifts" /id="U945" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=1095 /SigmaFactorBS="tcaagcaatcccgaatagggattgcttttttatttCTTCTGa ttttcagctttctgTCATATAGATAGAATATGAcacaatcggagggatgaagatgtct a" /listShort="cotO" /GFF_Attribute="listLong" promotor_-10 complement(1248649..1248663) /Source="Nicolas_upshift_promotors" /id="U946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.001998001998002" /xcortree=1241 /SigmaFactorBS="gagcggttttttatccgcgtttcttttcttattaGACATctt catcCCTCCGATTGTGTCAtattctatctatatgacagaaagctgaaaatcagaagaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1248649) /Source="Nicolas_upshifts" /id="U946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.001998001998002" /xcortree=1241 /SigmaFactorBS="gagcggttttttatccgcgtttcttttcttattaGACATctt catcCCTCCGATTGTGTCAtattctatctatatgacagaaagctgaaaatcagaagaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1248665..1249348 /gene="cotO" /locus_tag="BSU_11730" /old_locus_tag="BSU11730" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16321932" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore outer coat protein" /protein_id="NP_389055.1" /db_xref="EnsemblGenomes-Gn:BSU11730" /db_xref="EnsemblGenomes-Tr:CAB13030" /db_xref="GOA:O31622" /db_xref="InterPro:IPR025439" /db_xref="SubtiList:BG13153" /db_xref="UniProtKB/Swiss-Prot:O31622" /translation="MKMSNKKRNADKKPLMYIVQPDYAETTRSSMQEIVIKRKADKPA PPKAEEKPAYHEKQQEEAVAQDVLQEDQKPAAEPVSQQTQEAREPENIKSQEEQKAEP QAVEETVEHEPPKAEKKEEPALEARKPEKEPEAVHSADKAEEKAPPARKVKKPMSKMT IHEKIDFLTKLPHNMPRALCLIEANGRTYRGVIVGRRNDSVLLRTTGNGAPTELAIDD ITSLHPLGF*" gene 1248665..1249348 /gene="cotO" /locus_tag="BSU_11730" /old_locus_tag="BSU11730" promotor_-35 complement(1248671..1248675) /Source="Nicolas_upshift_promotors" /id="U946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.001998001998002" /xcortree=1241 /SigmaFactorBS="gagcggttttttatccgcgtttcttttcttattaGACATctt catcCCTCCGATTGTGTCAtattctatctatatgacagaaagctgaaaatcagaagaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1249343 /Source="Nicolas_upshifts" /id="D637" /incds=0 /nref=4 /ntot=40 /MaxReadThrough="3.37645" /MaxDrop="4.6587" /score="18.0229289" /energy="-13.4" /TU="U945" /idTUdmin="U945" /TUdmin="-66" /isTUend="FALSE" downshifts 1249431 /Source="Nicolas_upshifts" /id="D638" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.44926" /MaxDrop="4.55934" /score="18.0229289" /energy="-13.4" /TU="NA" /idTUdmin="U945" /TUdmin=22 /isTUend="TRUE" CDS complement(1249442..1249888) /gene="cotZ" /locus_tag="BSU_11740" /old_locus_tag="BSU11740" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331, 19933362, 26341943, 27320701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331, 19933362, 26341943, 27320701; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein (insoluble fraction, crust layer)" /protein_id="NP_389056.1" /db_xref="EnsemblGenomes-Gn:BSU11740" /db_xref="EnsemblGenomes-Tr:CAB13031" /db_xref="GOA:Q08312" /db_xref="InterPro:IPR019593" /db_xref="SubtiList:BG10499" /db_xref="UniProtKB/Swiss-Prot:Q08312" /translation="MSQKTSSCVREAVENIEDLQNAVEEDCPTGCHSKLLSVSHSLGD TVPFAIFTSKSTPLVAFGNVGELDNGPCFNTVFFRVERVHGSCATLSLLIAFDEHKHI LDFTDKDTVCEVFRLEKTNYCIEVDLDCFCAINCLNPRLINRTHHH*" gene complement(1249442..1249888) /gene="cotZ" /locus_tag="BSU_11740" /old_locus_tag="BSU11740" downshifts complement(1249463) /Source="Nicolas_upshifts" /id="D639" /incds=0 /nref=7 /ntot=50 /MaxReadThrough="8.44444" /MaxDrop="7.17581" /score="2.03943557" /energy="-9.3" /TU="U949" /idTUdmin="U950" /TUdmin=0 /isTUend="TRUE" S_feature complement(1249889..1250015) /Source="Nicolas_S_feature" /locus_tag="new_1249889_1250015_c" /HighExp="S8, S7, S6, BT, S5, B36, G/S, Pyr, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigEF" /TUshortPSig="1, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S420" CDS complement(1250016..1250504) /gene="cotY" /locus_tag="BSU_11750" /old_locus_tag="BSU11750" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331, 14766913, 26341943, 26821119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331, 14766913, 26341943, 26821119; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="outer spore coat protein (crust layer, insolublefraction)" /protein_id="NP_389057.1" /db_xref="EnsemblGenomes-Gn:BSU11750" /db_xref="EnsemblGenomes-Tr:CAB13032" /db_xref="GOA:Q08311" /db_xref="InterPro:IPR019593" /db_xref="SubtiList:BG10498" /db_xref="UniProtKB/Swiss-Prot:Q08311" /translation="MSCGKTHGRHENCVCDAVEKILAEQEAVEEQCPTGCYTNLLNPT IAGKDTIPFLVFDKKGGLFSTFGNVGGFVDDMQCFESIFFRVEKLCDCCATLSILRPV DVKGDTLSVCHPCDPDFFGLEKTDFCIEVDLGCFCAIQCLSPELVDRTSPHKDKKHHH NG*" gene complement(1250016..1250504) /gene="cotY" /locus_tag="BSU_11750" /old_locus_tag="BSU11750" promotor_-35 1250184..1250190 /Source="Nicolas_upshift_promotors" /id="U947" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.53046953046953" /psig="0.653346653346653" /xcortree=1630 /SigmaFactorBS="agggtggcaaacacttaaggtATCGCCTttgacatcgaccgg GCGTAAAATAGACAGTGTTGcacagcaatcgcataatttttcgacgcggaagaaaatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1250205..1250224 /Source="Nicolas_upshift_promotors" /id="U947" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.53046953046953" /psig="0.653346653346653" /xcortree=1630 /SigmaFactorBS="agggtggcaaacacttaaggtATCGCCTttgacatcgaccgg GCGTAAAATAGACAGTGTTGcacagcaatcgcataatttttcgacgcggaagaaaatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1250223 /Source="Nicolas_upshifts" /id="U947" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.53046953046953" /psig="0.653346653346653" /xcortree=1630 /SigmaFactorBS="agggtggcaaacacttaaggtATCGCCTttgacatcgaccgg GCGTAAAATAGACAGTGTTGcacagcaatcgcataatttttcgacgcggaagaaaatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 1250500..1250504 /Source="Nicolas_upshift_promotors" /id="U948" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.002997002997003" /xcortree=1244 /SigmaFactorBS="tctcatgccggccatgggtttttccgcagCTCATtgatttca GCTCCTTCTTTATAGggtatttgactttagtccttaacaacatatgtacccgtgcccc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1250513..1250527 /Source="Nicolas_upshift_promotors" /id="U948" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.002997002997003" /xcortree=1244 /SigmaFactorBS="tctcatgccggccatgggtttttccgcagCTCATtgatttca GCTCCTTCTTTATAGggtatttgactttagtccttaacaacatatgtacccgtgcccc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1250531 /Source="Nicolas_upshifts" /id="U948" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.002997002997003" /xcortree=1244 /SigmaFactorBS="tctcatgccggccatgggtttttccgcagCTCATtgatttca GCTCCTTCTTTATAGggtatttgactttagtccttaacaacatatgtacccgtgcccc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1250541..1250560) /Source="Nicolas_upshift_promotors" /id="U949" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1280 /SigmaFactorBS="tattttccaagcatatgatgaatatatagacgttcACCCACA CCAagtggggcacgggTACATATGTTGTTAAGGACTaaagtcaaataccctataaaga a" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1250558) /Source="Nicolas_upshifts" /id="U949" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1280 /SigmaFactorBS="tattttccaagcatatgatgaatatatagacgttcACCCACA CCAagtggggcacgggTACATATGTTGTTAAGGACTaaagtcaaataccctataaaga a" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" promotor_-35 complement(1250574..1250583) /Source="Nicolas_upshift_promotors" /id="U949" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1280 /SigmaFactorBS="tattttccaagcatatgatgaatatatagacgttcACCCACA CCAagtggggcacgggTACATATGTTGTTAAGGACTaaagtcaaataccctataaaga a" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1250590..1250608) /Source="Nicolas_upshift_promotors" /id="U950" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1006 /SigmaFactorBS="cttgtcctctaggacctaaaagcagagctaaaaacgctCTGC TTtttcttattttccaaGCATATGATGAATATATAGacgttcacccacaccaagtggg g" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1250607) /Source="Nicolas_upshifts" /id="U950" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1006 /SigmaFactorBS="cttgtcctctaggacctaaaagcagagctaaaaacgctCTGC TTtttcttattttccaaGCATATGATGAATATATAGacgttcacccacaccaagtggg g" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" promotor_-35 complement(1250624..1250629) /Source="Nicolas_upshift_promotors" /id="U950" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1006 /SigmaFactorBS="cttgtcctctaggacctaaaagcagagctaaaaacgctCTGC TTtttcttattttccaaGCATATGATGAATATATAGacgttcacccacaccaagtggg g" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1250641 /Source="Nicolas_upshifts" /id="D640" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="1.28604" /MaxDrop="4.18677" /score="-9.76125107" /energy="-10.4" /TU="NA" /idTUdmin="U948" /TUdmin=22 /isTUend="TRUE" CDS complement(1250656..1251174) /gene="cotX" /locus_tag="BSU_11760" /old_locus_tag="BSU11760" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331, 10400595, 10788508, 12031481, 19304857, 26821119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331, 10400595, 10788508, 12031481, 19304857, 26821119; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (insoluble fraction)" /protein_id="NP_389058.1" /db_xref="EnsemblGenomes-Gn:BSU11760" /db_xref="EnsemblGenomes-Tr:CAB13033" /db_xref="GOA:Q08313" /db_xref="InterPro:IPR011428" /db_xref="SubtiList:BG10500" /db_xref="UniProtKB/Swiss-Prot:Q08313" /translation="MESRPYSWVALDPDCDHPLDDKEKDKEKHERKCHCDVCCNGNGF FGNDNAFIDQDLAQANLNKQVSDETIIIRDSCDINVTSTDVQAVTSVVTALNAAVVTA TLTSIADGVIAELVAQDLLQLTANKQVNRQKLLIECSRGVNVTTVDADIATLISTATN TLVAILVITLVL*" gene complement(1250656..1251174) /gene="cotX" /locus_tag="BSU_11760" /old_locus_tag="BSU11760" downshifts complement(1250680) /Source="Nicolas_upshifts" /id="D641" /incds=0 /nref=76 /ntot=102 /MaxReadThrough="1.79219" /MaxDrop="8.69761" /score="18.5755652" /energy="-10.4" /TU="U952" /idTUdmin="U952" /TUdmin="-29" /isTUend="FALSE" downshifts 1250685 /Source="Nicolas_upshifts" /id="D642" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="1.2156" /MaxDrop="3.69222" /score="-9.76125107" /energy="-10.4" /TU="NA" /idTUdmin="U948" /TUdmin=66 /isTUend="FALSE" S_feature complement(1251175..1251272) /Source="Nicolas_S_feature" /locus_tag="new_1251175_1251272_c" /HighExp="S8, S7, S6, BT, B36, G/S, Pyr, S5, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.748" /TUlongSig="SigK" /TUlongPSig="0.98" /label="S421" CDS complement(1251273..1251590) /gene="cotW" /locus_tag="BSU_11770" /old_locus_tag="BSU11770" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8509331, 19304857, 21665972, 25872412" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8509331, 19304857, 21665972, 25872412; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (outemost layer)" /protein_id="NP_389059.1" /db_xref="EnsemblGenomes-Gn:BSU11770" /db_xref="EnsemblGenomes-Tr:CAB13034" /db_xref="GOA:Q08310" /db_xref="SubtiList:BG10497" /db_xref="UniProtKB/Swiss-Prot:Q08310" /translation="MSDNDKFKEELAKLPEVDPMTKMLVQNIFSKHGVTKDKMKKVSD EEKEMLLNLVKDLQAKSQALIENQKKKKEEAAAQEQKNTKPLSRREQLIEQIRQRRKN DNN*" gene complement(1251273..1251590) /gene="cotW" /locus_tag="BSU_11770" /old_locus_tag="BSU11770" CDS complement(1251631..1252017) /gene="cotV" /locus_tag="BSU_11780" /old_locus_tag="BSU11780" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (insoluble fraction)" /protein_id="NP_389060.1" /db_xref="EnsemblGenomes-Gn:BSU11780" /db_xref="EnsemblGenomes-Tr:CAB13035" /db_xref="GOA:Q08309" /db_xref="InterPro:IPR011428" /db_xref="SubtiList:BG10496" /db_xref="UniProtKB/Swiss-Prot:Q08309" /translation="MSFEEKVESLHPAIFEQLSSEFEQQIEVIDCENITIDTSHITAA LSIQAFVTTMIIVATQLVIADEDLADAVASEILILDSSQIKKRTIIKIINSRNIKITL SADEIITFVQILLQVLNSILSELDVL*" gene complement(1251631..1252017) /gene="cotV" /locus_tag="BSU_11780" /old_locus_tag="BSU11780" promotor_-35 1252013..1252017 /Source="Nicolas_upshift_promotors" /id="U951" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.005994005994006" /xcortree=1245 /SigmaFactorBS="ttgctcaaatattgcagggtgcagggattcgactttttcttc aaatGACATaaccttcACTCCTTTCTTATCCatactctatataatgcaaatggggtgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1252025..1252039 /Source="Nicolas_upshift_promotors" /id="U951" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.005994005994006" /xcortree=1245 /SigmaFactorBS="ttgctcaaatattgcagggtgcagggattcgactttttcttc aaatGACATaaccttcACTCCTTTCTTATCCatactctatataatgcaaatggggtgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1252027 /Source="Nicolas_upshifts" /id="U951" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.005994005994006" /xcortree=1245 /SigmaFactorBS="ttgctcaaatattgcagggtgcagggattcgactttttcttc aaatGACATaaccttcACTCCTTTCTTATCCatactctatataatgcaaatggggtgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1252037..1252056) /Source="Nicolas_upshift_promotors" /id="U952" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.748251748251748" /psig="0.748251748251748" /xcortree=1351 /SigmaFactorBS="catgaattgtatcttgtccggcagaaaattggttatttttat taTtCcGctctgcaccccattTGCATTATATAGAGTATGGAtaagaaaggagtgaagg t" /listShort="cotV, cotW, S421, cotX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1252059) /Source="Nicolas_upshifts" /id="U952" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.748251748251748" /psig="0.748251748251748" /xcortree=1351 /SigmaFactorBS="catgaattgtatcttgtccggcagaaaattggttatttttat taTtCcGctctgcaccccattTGCATTATATAGAGTATGGAtaagaaaggagtgaagg t" /listShort="cotV, cotW, S421, cotX" /GFF_Attribute="listLong" S_feature complement(1252061..1252565) /Source="Nicolas_S_feature" /locus_tag="new_1252061_1252565_c" /HighExp="S8, S6, S7, BT, S5, B36, Pyr, C30, G/S, nit" /AntisenseName="yjcA" /AntisenseCor="0.69838474492609404" /AntisenseRegPval="-39.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S422" promotor_-35 complement(1252075) /Source="Nicolas_upshift_promotors" /id="U952" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.748251748251748" /psig="0.748251748251748" /xcortree=1351 /SigmaFactorBS="catgaattgtatcttgtccggcagaaaattggttatttttat taTtCcGctctgcaccccattTGCATTATATAGAGTATGGAtaagaaaggagtgaagg t" /listShort="cotV, cotW, S421, cotX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1252114..1252119 /Source="Nicolas_upshift_promotors" /id="U953" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1132 /SigmaFactorBS="aataaaaataaccaattttctgccggacaagatacaaTTCAT GaagaatagggttttgGCATATATGTGAAGGGATCatgattggcaaaggagtgaacga g" /listShort="yjcA, S423" /listLong="yjzK, yjcZ, S424, spoVIF, S425" /label="promotor_-35" promotor_-10 1252135..1252153 /Source="Nicolas_upshift_promotors" /id="U953" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1132 /SigmaFactorBS="aataaaaataaccaattttctgccggacaagatacaaTTCAT GaagaatagggttttgGCATATATGTGAAGGGATCatgattggcaaaggagtgaacga g" /listShort="yjcA, S423" /listLong="yjzK, yjcZ, S424, spoVIF, S425" /label="promotor_-10" upshifts 1252137 /Source="Nicolas_upshifts" /id="U953" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1132 /SigmaFactorBS="aataaaaataaccaattttctgccggacaagatacaaTTCAT GaagaatagggttttgGCATATATGTGAAGGGATCatgattggcaaaggagtgaacga g" /listShort="yjcA, S423" /listLong="yjzK, yjcZ, S424, spoVIF, S425" CDS 1252177..1252533 /gene="yjcA" /locus_tag="BSU_11790" /old_locus_tag="BSU11790" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523132, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523132, 15849754, 16850406; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protein" /protein_id="NP_389061.1" /db_xref="EnsemblGenomes-Gn:BSU11790" /db_xref="EnsemblGenomes-Tr:CAB13036" /db_xref="GOA:O31623" /db_xref="InterPro:IPR010773" /db_xref="SubtiList:BG13154" /db_xref="UniProtKB/Swiss-Prot:O31623" /translation="MVINGLTIVLLSLAVFRLARLLVFDTIMAPLRSLFHEEKEEKDA DGNIETYIVIKGTGVRAFIGELLSCYWCTGVWCAGFLILCQAVIPQAAQWLILLLAIA GLAGIIETLVSKWLQE*" gene 1252177..1252533 /gene="yjcA" /locus_tag="BSU_11790" /old_locus_tag="BSU11790" promotor_-35 1252543..1252552 /Source="Nicolas_upshift_promotors" /id="U955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1353 /SigmaFactorBS="gctcgtatcaaaatggctgcaagaataaggcgttaccACCAG CAACTttctgtcagaataCGCATAAAGTAGCATATAtgacataaggaaaggaagggga c" /listShort="S423, yjzK" /listLong="yjcZ, S424, spoVIF, S425" /label="promotor_-35" promotor_-10 complement(1252550..1252569) /Source="Nicolas_upshift_promotors" /id="U954" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1256 /SigmaFactorBS="atgatgctgattcatttttgtccccttcctttcCTTATGTCA TatatgctactttaTGCGTATTCTGACAGAAAGTtgctggtggtaacgccttattctt g" /listShort="S422" /listLong="cotV, cotW, S421, cotX" /label="promotor_-10" CDS complement(1252558..1252791) /locus_tag="BSU_11798" /old_locus_tag="BSU11798" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="protein remnant" /db_xref="PSEUDO:SOX90549.1" /translation="MLSETASLKKQKTGVLRFLCQAIEAFSFYFRTRSLSFLSFLIDT MNLYMEIFGKVYDADSFLSPSFPYVIYATLCVF*" gene complement(1252558..1252791) /locus_tag="BSU_11798" /old_locus_tag="BSU11798" /pseudo upshifts complement(1252565) /Source="Nicolas_upshifts" /id="U954" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1256 /SigmaFactorBS="atgatgctgattcatttttgtccccttcctttcCTTATGTCA TatatgctactttaTGCGTATTCTGACAGAAAGTtgctggtggtaacgccttattctt g" /listShort="S422" /listLong="cotV, cotW, S421, cotX" S_feature 1252566..1252752 /Source="Nicolas_S_feature" /locus_tag="new_1252566_1252752" /HighExp="S8, S6, S7, BT, S5, B36, S4, S3, G/S, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.26970100000000002" /TUshortSig="SigK, SigEF" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S423" promotor_-10 1252566..1252583 /Source="Nicolas_upshift_promotors" /id="U955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1353 /SigmaFactorBS="gctcgtatcaaaatggctgcaagaataaggcgttaccACCAG CAACTttctgtcagaataCGCATAAAGTAGCATATAtgacataaggaaaggaagggga c" /listShort="S423, yjzK" /listLong="yjcZ, S424, spoVIF, S425" /label="promotor_-10" upshifts 1252566 /Source="Nicolas_upshifts" /id="U955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1353 /SigmaFactorBS="gctcgtatcaaaatggctgcaagaataaggcgttaccACCAG CAACTttctgtcagaataCGCATAAAGTAGCATATAtgacataaggaaaggaagggga c" /listShort="S423, yjzK" /listLong="yjcZ, S424, spoVIF, S425" promotor_-35 complement(1252583..1252592) /Source="Nicolas_upshift_promotors" /id="U954" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1256 /SigmaFactorBS="atgatgctgattcatttttgtccccttcctttcCTTATGTCA TatatgctactttaTGCGTATTCTGACAGAAAGTtgctggtggtaacgccttattctt g" /listShort="S422" /listLong="cotV, cotW, S421, cotX" /label="promotor_-35" downshifts complement(1252609) /Source="Nicolas_upshifts" /id="D643" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="3.12564" /MaxDrop="4.58782" /score="-6.14331629" /energy="-6.8" /TU="NA" /idTUdmin="U954" /TUdmin="-528" /isTUend="FALSE" downshifts 1252709 /Source="Nicolas_upshifts" /id="D644" /incds=0 /nref=3 /ntot=32 /MaxReadThrough="5.73879" /MaxDrop="3.6919" /score="33.8150878" /energy="-6.8" /TU="U953,U955" /idTUdmin="U953" /TUdmin="-66" /isTUend="FALSE" upshifts complement(1252763) /Source="Nicolas_upshifts" /id="U956" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.284715284715285" /psig="0.032967032967033" /xcortree=768 /SigmaFactorBS="ctcattcacttttatccccccgcttatgatatatgctgagcg agaCCGCCTCGttaaaaaaacaaaaaaccggagttctccggtttctttgccaggctat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 1252764..1252773 /Source="Nicolas_upshift_promotors" /id="U957" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1288 /SigmaFactorBS="gaaaccggagaactccggttttttgttTTTTTAACGAggcgg tctcgctcAGCATATATCATAAGCGGGGggataaaagtgaatgagtttgaaaaatgga t" /listShort="yjzK, yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1252771..1252778) /Source="Nicolas_upshift_promotors" /id="U956" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.284715284715285" /psig="0.032967032967033" /xcortree=768 /SigmaFactorBS="ctcattcacttttatccccccgcttatgatatatgctgagcg agaCCGCCTCGttaaaaaaacaaaaaaccggagttctccggtttctttgccaggctat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1252787..1252806 /Source="Nicolas_upshift_promotors" /id="U957" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1288 /SigmaFactorBS="gaaaccggagaactccggttttttgttTTTTTAACGAggcgg tctcgctcAGCATATATCATAAGCGGGGggataaaagtgaatgagtttgaaaaatgga t" /listShort="yjzK, yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1252797 /Source="Nicolas_upshifts" /id="U957" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1288 /SigmaFactorBS="gaaaccggagaactccggttttttgttTTTTTAACGAggcgg tctcgctcAGCATATATCATAAGCGGGGggataaaagtgaatgagtttgaaaaatgga t" /listShort="yjzK, yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" CDS 1252815..1253021 /gene="yjzK" /locus_tag="BSU_11799" /old_locus_tag="BSU11799" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097704.1" /db_xref="EnsemblGenomes-Gn:BSU11799" /db_xref="EnsemblGenomes-Tr:CAX52594" /db_xref="UniProtKB/Swiss-Prot:C0H3Y7" /translation="MNEFEKWIEGRYEPHEQKQKEHEDTMGSIRKDLDAFDKAGLEFE DEIEELAEKTEALLKKHQAQYDQS*" gene 1252815..1253021 /gene="yjzK" /locus_tag="BSU_11799" /old_locus_tag="BSU11799" CDS 1252858..1253073 /gene="yjcB" /locus_tag="BSU_11800" /old_locus_tag="BSU11800" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523132; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protein" /protein_id="YP_009513951.1" /translation="MNKSKKSMKTRWAVSEKTWMHLIKPVWNLKMRLKSWLKKRRPYL KNIKLNMINRKSANALCEYPSRSQQLT*" gene 1252858..1253073 /gene="yjcB" /locus_tag="BSU_11800" /old_locus_tag="BSU11800" promotor_-35 1253045..1253054 /Source="Nicolas_upshift_promotors" /id="U958" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1409 /SigmaFactorBS="tcaatcgtaaatccgcaaacgccctatgcgaatATCCAAGCC GatcccagcagctCACATAGTGTATAGAGAGTAaaggaggtgcttatctatgggcttt g" /listShort="yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1253067..1253086 /Source="Nicolas_upshift_promotors" /id="U958" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1409 /SigmaFactorBS="tcaatcgtaaatccgcaaacgccctatgcgaatATCCAAGCC GatcccagcagctCACATAGTGTATAGAGAGTAaaggaggtgcttatctatgggcttt g" /listShort="yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1253072 /Source="Nicolas_upshifts" /id="U958" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1409 /SigmaFactorBS="tcaatcgtaaatccgcaaacgccctatgcgaatATCCAAGCC GatcccagcagctCACATAGTGTATAGAGAGTAaaggaggtgcttatctatgggcttt g" /listShort="yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" promotor_-10 complement(1253079..1253093) /Source="Nicolas_upshift_promotors" /id="U959" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=690 /SigmaFactorBS="gccataacagccgccgccgtagccgccgccgaatccgtatcc aaagCCCATagataagcaCCTCCTTTACTCTCTatacactatgtgagctgctgggatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1253093) /Source="Nicolas_upshifts" /id="U959" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=690 /SigmaFactorBS="gccataacagccgccgccgtagccgccgccgaatccgtatcc aaagCCCATagataagcaCCTCCTTTACTCTCTatacactatgtgagctgctgggatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1253103..1253107) /Source="Nicolas_upshift_promotors" /id="U959" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=690 /SigmaFactorBS="gccataacagccgccgccgtagccgccgccgaatccgtatcc aaagCCCATagataagcaCCTCCTTTACTCTCTatacactatgtgagctgctgggatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1253103..1253252 /gene="yjcZ" /locus_tag="BSU_11809" /old_locus_tag="BSU11809" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523132, 20156992, 21670523; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097705.1" /db_xref="EnsemblGenomes-Gn:BSU11809" /db_xref="EnsemblGenomes-Tr:CAX52595" /db_xref="GOA:C0H3Y8" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Y8" /translation="MGFGYGFGGGYGGGCYGGYAGGYGGGYGSTFVLLVVLFILLIIV GASFF*" gene 1253103..1253252 /gene="yjcZ" /locus_tag="BSU_11809" /old_locus_tag="BSU11809" downshifts 1253193 /Source="Nicolas_upshifts" /id="D645" /incds=0 /nref=4 /ntot=29 /MaxReadThrough="8.16203" /MaxDrop="4.48861" /score="1.53429015" /energy="-22.4" /TU="U957,U958" /idTUdmin="U955" /TUdmin=110 /isTUend="FALSE" S_feature 1253253..1253384 /Source="Nicolas_S_feature" /locus_tag="new_1253253_1253384" /HighExp="S7, BT, S8, B36, S6, G/S, Pyr, B60, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigK" /TUshortPSig="1, 0.971" /TUlongSig="SigK, SigEF" /TUlongPSig="0.999, 1" /label="S424" CDS 1253385..1253639 /gene="spoVIF" /locus_tag="BSU_11810" /old_locus_tag="BSU11810" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523132, 14702409, 20435725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523132, 14702409, 20435725; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protein needed for heat resistance" /protein_id="NP_389063.2" /db_xref="EnsemblGenomes-Gn:BSU11810" /db_xref="EnsemblGenomes-Tr:CAB13038" /db_xref="GOA:O31625" /db_xref="InterPro:IPR025942" /db_xref="SubtiList:BG13156" /db_xref="UniProtKB/Swiss-Prot:O31625" /translation="MDNQFFKNIEKKTGVKMQDVMNLAGSLQNANFKDENTVRSVINR VAQMANRRVPKELEDKIVESITSGKEKLDFGTISKMMDNK*" gene 1253385..1253639 /gene="spoVIF" /locus_tag="BSU_11810" /old_locus_tag="BSU11810" downshifts 1253624 /Source="Nicolas_upshifts" /id="D646" /incds=0 /nref=40 /ntot=79 /MaxReadThrough="5.66609" /MaxDrop="5.8411" /score="7.68851688" /energy="-10.7" /TU="U957,U958" /idTUdmin="U955" /TUdmin=541 /isTUend="FALSE" downshifts complement(1253643) /Source="Nicolas_upshifts" /id="D647" /incds=0 /nref=3 /ntot=9 /MaxReadThrough="3.12148" /MaxDrop="4.34051" /score="24.4726468" /energy="-14.3" /TU="NA" /idTUdmin="U961" /TUdmin=88 /isTUend="FALSE" S_feature 1253669..1254769 /Source="Nicolas_S_feature" /locus_tag="new_1253669_1254769" /HighExp="S8, S6, S7, B36, S5, C30, BT, dia15, Diami, H2O2" /AntisenseName="yjcD" /AntisenseCor="-0.210610370451118" /AntisenseRegPval="-3.3" /CDS_PredictionProba="0.18426200000000001" /TUshortSig="SigK, SigK" /TUshortPSig="1, 0.971" /TUlongSig="SigK, SigEF" /TUlongPSig="0.999, 1" /label="S425" CDS complement(1253713..1255992) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544244, 16014871, 17114254, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent DNA helicase (sporulationassociated)" /protein_id="NP_389064.3" /db_xref="EnsemblGenomes-Gn:BSU11820" /db_xref="EnsemblGenomes-Tr:CAB13039" /db_xref="GOA:O31626" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG13157" /db_xref="UniProtKB/Swiss-Prot:O31626" /translation="MKCARLNDRIIHLHTYSREHYQFLFEEGIKGHLFCSHCGKPVLL RLNIADPPEFIHRQPGDFPACEEACEPKPSKEGKKEDDQESGVIRLPKGKAIAADPSP AVTEWHRPRSIKPGTPFVPKTIEPDTSLFPSVGLNTDQLKAVTETEGPLLVLAGAGSG KTRVLTARAAHMIEHLGIPPENMLLVTFTTKAVAEMKERMANQYGLQPAKVRRIVTGT FHSLFYKILYHSNSAKWNGEHLLKMEWQREQYIKKALYEEGIDEKESPVDQALQQIGF WKNTYVPNERIPLKDEWEKQVYRLYEHYERQKKEHSQFDFDDMASACYELFIERPDLL EQYQSRFTYILIDEFQDINPVQYKIMQMLASPEQNLCCVGDDDQSIYAFRGSNPSFIL DFQKDYPGAKTIYLTANYRSTHPIVSSADIVVKKNKNRYAKTLEAARDDIQVPVLFYP YDEEEEATMVVSDIKEKIQNGASPEDFAVLYRTNSGGRAIYERLHQSSIPYTADRGVQ SFYSRRIVRQILAYLYASQNEDDTEAIKHLLPALFLKQSALNTLKALSITEDCTMIKA LAKLPDLKPFQLDKIKKIVPFFASLRTMKPVEAITFAEGKMGFSEYLKKRGNEGNKLE KGSDDLRDIKVVAKKFKTIPDFLAHVDHMRAAEKNRTDEHGVQLMTIHRSKGLEFKTV YVLGTVDGSIPHDFSLETARKGDEAALEEERRLLYVAMTRAKQHLYLSCPANRRGKTA NRSRFLYPLLQKARQPLHH*" gene complement(1253713..1255992) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" downshifts complement(1253731) /Source="Nicolas_upshifts" /id="D648" /incds=0 /nref=61 /ntot=171 /MaxReadThrough="2.59869" /MaxDrop="4.36061" /score="24.4726468" /energy="-14.3" /TU="NA" /idTUdmin="U961" /TUdmin=0 /isTUend="TRUE" S_feature complement(1255867..1256041) /Source="Nicolas_S_feature" /locus_tag="new_1255867_1256041_c" /HighExp="G180, G135, G150, H2O2, Paraq, Oxctl, LBGexp, dia15, dia0, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S426" promotor_-35 1255920..1255928 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1255939..1255957 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1255943..1256078 /Source="Nicolas_S_feature" /locus_tag="new_1255943_1256078" /HighExp="S4, S5, S3, S6, S7, S8, M9-stat, T4.0H, T3.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S427" upshifts 1255943 /Source="Nicolas_upshifts" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" promotor_-10 complement(1256029..1256048) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1256040) /Source="Nicolas_upshifts" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" promotor_-35 1256056..1256062 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1256064..1256068) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1256077..1256095 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1256080 /Source="Nicolas_upshifts" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" CDS 1256109..1256363 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11976315, 23155385" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097706.1" /db_xref="EnsemblGenomes-Gn:BSU11839" /db_xref="EnsemblGenomes-Tr:CAX52596" /db_xref="UniProtKB/Swiss-Prot:C0H3Y9" /translation="MIYAGQIQNQQYAQYANRTIGHKQDYAGTEKISYVPFQRVYKEL EKQQENQTAAERKVNEMKRKRSLYKRLREKGMGTYINRYV*" gene 1256109..1256363 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" downshifts 1256339 /Source="Nicolas_upshifts" /id="D649" /incds=0 /nref=101 /ntot=248 /MaxReadThrough="3.69482" /MaxDrop="7.80206" /score="5.37568515" /energy="-6.1" /TU="U962" /idTUdmin="U960" /TUdmin=0 /isTUend="TRUE" downshifts complement(1256429) /Source="Nicolas_upshifts" /id="D650" /incds=0 /nref=78 /ntot=283 /MaxReadThrough="3.21062" /MaxDrop="7.8562" /score="-4.05705392" /energy="-6.1" /TU="U963" /idTUdmin="U963" /TUdmin="-36" /isTUend="FALSE" CDS complement(1256436..1256858) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389066.1" /db_xref="EnsemblGenomes-Gn:BSU11840" /db_xref="EnsemblGenomes-Tr:CAB13041" /db_xref="GOA:O31628" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1Q2Y" /db_xref="SubtiList:BG13159" /db_xref="UniProtKB/Swiss-Prot:O31628" /translation="MKAVIAKNEEQLKDAFYVREEVFVKEQNVPAEEEIDELENESEH IVVYDGEKPVGAGRWRMKDGYGKLERICVLKSHRSAGVGGIIMKALEKAAADGGASGF ILNAQTQAVPFYKKHGYRVLSEKEFLDAGIPHLQMMKD*" gene complement(1256436..1256858) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" CDS complement(1256862..1257377) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12466548, 16511078, 17012785, 18473364, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA ligase or phosphoesterase" /protein_id="NP_389067.1" /db_xref="EnsemblGenomes-Gn:BSU11850" /db_xref="EnsemblGenomes-Tr:CAB13042" /db_xref="GOA:O31629" /db_xref="InterPro:IPR009097" /db_xref="InterPro:IPR022932" /db_xref="PDB:2D4G" /db_xref="SubtiList:BG13160" /db_xref="UniProtKB/Swiss-Prot:O31629" /translation="MKYGIVLFPSKKLQDLANSYRKRYDPSYSLIPPHLTLRASFECA EEKADQLVSHLRNIAKESHPLVLKMTKYSSFAPVNNVIYIKAEPTEELKTLNEKLYTG VLAGEQEYNFVPHVTVGQNLSDDEHSDVLGQLKMQEVSHEEIVDRFHLLYQLENGSWT VYETFLLGRGE*" gene complement(1256862..1257377) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" CDS complement(1257414..1258136) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative stress-related hydrolase" /protein_id="NP_389068.1" /db_xref="EnsemblGenomes-Gn:BSU11860" /db_xref="EnsemblGenomes-Tr:CAB13043" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13161" /db_xref="UniProtKB/Swiss-Prot:O31630" /translation="MAPKNGTVQEKKFFSKELNEEMTLLVYLPSNYSPLYKYHVIIAQ DGHDYFRLGRIGRQVEELLSKREIDRSIIIGVPYKDVKERRNTYHPEGSKFSAYKRFI AHELVPFADDEYPTYQIGYGRTLIGDSLGATVSLMTALDYPNMFGNIIMQSPYVDKHV LEAVKQSDDIKHLSIYHQIGTKETDVHTTDGNILDFTEPNRELKQLLEKKLSDYDFEP FDGDHKWTYWQPLITPALKKML*" gene complement(1257414..1258136) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" misc_feature complement(1258175..1258194) /Source="Nicolas_upshift_promotors" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1258196) /Source="Nicolas_upshifts" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" promotor_-35 1258245..1258252 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1258267..1258286 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1258271 /Source="Nicolas_upshifts" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" misc_RNA 1258304..1258424 /gene="mswA" /locus_tag="BSU_misc_RNA_15" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" gene 1258304..1258424 /gene="mswA" /locus_tag="BSU_misc_RNA_15" downshifts 1258429 /Source="Nicolas_upshifts" /id="D651" /incds=0 /nref=8 /ntot=59 /MaxReadThrough="7.71668" /MaxDrop="5.0477" /score="31.1477774" /energy="-15.2" /TU="U964" /idTUdmin="U962" /TUdmin=2024 /isTUend="FALSE" CDS 1258492..1259613 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" /EC_number="2.5.1.49" /EC_number="2.5.1.48" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-synthase and O-acetylhomoserine thiolyase" /protein_id="NP_389069.1" /db_xref="EnsemblGenomes-Gn:BSU11870" /db_xref="EnsemblGenomes-Tr:CAB13044" /db_xref="GOA:O31631" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13162" /db_xref="UniProtKB/Swiss-Prot:O31631" /translation="MSQHVETKLAQIGNRSDEVTGTVSAPIYLSTAYRHRGIGESTGF DYVRTKNPTRQLVEDAIANLENGARGLAFSSGMAAIQTIMALFKSGDELIVSSDLYGG TYRLFENEWKKYGLTFHYDDFSDEDCLRSKITPNTKAVFVETPTNPLMQEADIEHIAR ITKEHGLLLIVDNTFYTPVLQRPLELGADIVIHSATKYLGGHNDLLAGLVVVKDERLG EEMFQHQNAIGAVLPPFDSWLLMRGMKTLSLRMRQHQANAQELAAFLEEQEEISDVLY PGKGGMLSFRLQKEEWVNPFLKALKTICFAESLGGVESFITYPATQTHMDIPEEIRIA NGVCNRLLRFSVGIEHAEDLKEDLKQALCQVKEGAVSFE*" gene 1258492..1259613 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" CDS 1259606..1260778 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" /EC_number="4.4.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 11948165, 15760717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 11948165, 15760717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-lyase" /protein_id="NP_389070.1" /db_xref="EnsemblGenomes-Gn:BSU11880" /db_xref="EnsemblGenomes-Tr:CAB13045" /db_xref="GOA:O31632" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13163" /db_xref="UniProtKB/Swiss-Prot:O31632" /translation="MSKHNWTLETQLVHNPFKTDGGTGAVSVPIQHASTFHQSSFEEF GAYDYSRSGTPTRTALEETIAALEGGTRGFAFSSGMAAISTAFLLLSQGDHVLVTEDV YGGTFRMVTEVLTRFGIEHTFVDMTDRNEVARSIKPNTKVIYMETPSNPTLGITDIKA VVQLAKENGCLTFLDNTFMTPALQRPLDLGVDIVLHSATKFLSGHSDVLSGLAAVKDE ELGKQLYKLQNAFGAVLGVQDCWLVLRGLKTLQVRLEKASQTAQRLAEFFQKHPAVKR VYYPGLADHPGAETHKSQSTGAGAVLSFELESKEAVKKLVENVSLPVFAVSLGAVESI LSYPATMSHAAMPKEEREKRGITDGLLRLSVGVEHADDLEHDFEQALKEIAPVSVR*" gene 1259606..1260778 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" downshifts 1260761 /Source="Nicolas_upshifts" /id="D652" /incds=0 /nref=108 /ntot=205 /MaxReadThrough="4.73188" /MaxDrop="5.54268" /score="4.00424187" /energy="-9.2" /TU="U964" /idTUdmin="U964" /TUdmin="-1474" /isTUend="FALSE" misc_feature 1260795..1260813 /Source="Nicolas_upshift_promotors" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1260805 /Source="Nicolas_upshifts" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" S_feature 1260806..1262335 /Source="Nicolas_S_feature" /locus_tag="new_1260806_1262335" /HighExp="MG 5, MG t5, MG 10, BMM, GM 25, MG 15, Glu, GM 15, GM 45, GM 10" /AntisenseName="yjcK" /AntisenseCor="0.123731990206979" /AntisenseRegPval="-1.4" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.671, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S428" CDS complement(1260811..1261356) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" /EC_number="2.3.1.267" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2828880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal-protein-alanine N-acetyltransferase" /protein_id="NP_389071.1" /db_xref="EnsemblGenomes-Gn:BSU11890" /db_xref="EnsemblGenomes-Tr:CAB13046" /db_xref="GOA:O31633" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13164" /db_xref="UniProtKB/Swiss-Prot:O31633" /translation="MLKGKTIYVRPLEVTDAEENLGLQSENRDFFEQFSMIRADDYYT VEGQRKRITEYQERLEKDEEYHFGIFTASDDRLIGTVSLFQIIRGALQTAFIGYFLDK AHNGKGIMTEAVRLVVDYAFHELKLHRIEAGVMPRNLGSMRVLEKAGFHKEGIARKNV KINGVWEDHQVLAILNPDDEQ*" gene complement(1260811..1261356) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" downshifts complement(1260832) /Source="Nicolas_upshifts" /id="D653" /incds=0 /nref=14 /ntot=127 /MaxReadThrough="0.4032" /MaxDrop="4.23858" /score="-7.12102596" /energy="-7.3" /TU="NA" /idTUdmin="U966" /TUdmin="-17" /isTUend="TRUE" CDS complement(1261426..1262616) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein; possibly aquaporin-related" /protein_id="NP_389072.1" /db_xref="EnsemblGenomes-Gn:BSU11900" /db_xref="EnsemblGenomes-Tr:CAB13047" /db_xref="GOA:O31634" /db_xref="InterPro:IPR008537" /db_xref="SubtiList:BG13165" /db_xref="UniProtKB/Swiss-Prot:O31634" /translation="MHSLISSDDVWVLWGFIAVWAAVSIGLEQRFKWASAVSGAIIAL AGAMVFTNVGVLPVESPVYDTVWSYVVPLAIPLLLFQINVRQIFKESRRLLFIFLISS VGTVLGSILAFFLLKQHIPYLDKIGGMISASYIGGGVNFAAMAAKFETPGEYVSATVV ADNFMMALLFFILISIPALKWFQRHYAMPFEEKVKADGNSGNSAESYWKRKDISLKDI AFNAGAAFALVAVSMKVSGYFKSIFSHPLLTGTLGDQYLVLTSLTVLIIFLFPRFFER LNGSQELGTFLIYLFFVVIGIPADLRLIVTNAPLILLFVFIIAISNLAVSLAAGKLFR VRLEEILLAVNATVGGPTTAAAMAIAKGWRELVAPIMLVGTLGYLIGNYVGTFMGNWF SSFL*" gene complement(1261426..1262616) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" promotor_-10 complement(1262642..1262661) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1262646) /Source="Nicolas_upshifts" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" promotor_-35 complement(1262676..1262683) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1262710..1262717 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1262721 /Source="Nicolas_upshifts" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" promotor_-10 1262731..1262750 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-10" tRNA 1262789..1262861 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="valine tRNA (GAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 1262789..1262861 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" promotor_-10 complement(1262803..1262820) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1262817) /Source="Nicolas_upshifts" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1262841..1262847) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1262851 /Source="Nicolas_upshifts" /id="D654" /incds=0 /nref=17 /ntot=80 /MaxReadThrough="4.64061" /MaxDrop="5.10012" /score="20.8247903" /energy="-9.1" /TU="U967" /idTUdmin="U965" /TUdmin=550 /isTUend="FALSE" S_feature complement(1262876..1263611) /Source="Nicolas_S_feature" /locus_tag="new_1262876_1263611_c" /HighExp="M9-stat, Lbstat, M0t90, Pyr, T0.30H, M40t90, C30, S1, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S429" S_feature 1262896..1264544 /Source="Nicolas_S_feature" /locus_tag="new_1262896_1264544" /HighExp="Cold, C30, G135, G180, G150, Oxctl, Fru, HPh, Glu, UNK1" /AntisenseName="yjcM" /AntisenseCor="0.46809452811910301" /AntisenseRegPval="-15.3" /CDS_PredictionProba="0.27514300000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S430" downshifts complement(1262905) /Source="Nicolas_upshifts" /id="D655" /incds=0 /nref=29 /ntot=192 /MaxReadThrough="1.23936" /MaxDrop="3.57085" /score="-4.98447688" /energy="-7.9" /TU="NA" /idTUdmin="U970" /TUdmin=0 /isTUend="TRUE" S_feature complement(1263613..1263701) /Source="Nicolas_S_feature" /locus_tag="new_1263613_1263701_c" /HighExp="aero, HPh, M0t45, SMM, dia0, GM 150, Mal, M/G, Mt0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S431" downshifts complement(1263656) /Source="Nicolas_upshifts" /id="D656" /incds=0 /nref=34 /ntot=148 /MaxReadThrough="4.13737" /MaxDrop="4.5557" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-751" /isTUend="FALSE" CDS complement(1263702..1264931) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20011599" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389073.1" /db_xref="EnsemblGenomes-Gn:BSU11910" /db_xref="EnsemblGenomes-Tr:CAB13048" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG13166" /db_xref="UniProtKB/Swiss-Prot:O31635" /translation="MKKELLASLVLCLSLSPLVSTNEVFAATTNKETKENVSITNEIG YEKVKDMLEQQKYDFEHNTPLAHPKESKLTDSDEGVLLYSALSKVDKQKFHEFTYDID DVKTSEKNNKLIVEAYITRNFVFGVEKVTTSLGDNIKLEIPKTTSNKQSSQSTNTSNL SFSQVKNSSNQLNVIPLSNSSKQLNVTQLNNSSSTLQYENDEEYSSDVKLDEFLKKYK QEVKNDDKEEVKSEDKPVSMNFNAANSNQLTVTATSVKGYSGYAAMKYAEKYALKPNK NYKYYKDKDCTNFVSQALRAGRMPYFKEWKPYTDAWVNAGAFRSYILKAGGIKMKTVS DTYSNVKLGDVYHYDYHNKIGLRYADGWMDHTAIVTSRANMKLYVSYHSTNRLNVPRE YVTSKEGGKRYVSSIRN*" gene complement(1263702..1264931) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" downshifts complement(1263824) /Source="Nicolas_upshifts" /id="D657" /incds=1 /nref=4 /ntot=143 /MaxReadThrough="5.58558" /MaxDrop="3.45178" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-919" /isTUend="FALSE" downshifts 1264501 /Source="Nicolas_upshifts" /id="D658" /incds=1 /nref=1 /ntot=48 /MaxReadThrough="3.19343" /MaxDrop="1.98614" /score="26.2462772" /energy="-24.7" /TU="NA" /idTUdmin="U967" /TUdmin=0 /isTUend="TRUE" S_feature complement(1264932..1265017) /Source="Nicolas_S_feature" /locus_tag="new_1264932_1265017_c" /HighExp="aero, SMM, T-3.40H, MG 150, Lbexp, SMMPr, GM 90, C90, nit, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S432" promotor_-35 1264972..1264979 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1264994..1265013 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1265003..1265022) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1265007 /Source="Nicolas_upshifts" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" upshifts complement(1265021) /Source="Nicolas_upshifts" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" promotor_-35 complement(1265035..1265041) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1265057..1265377 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389074.1" /db_xref="EnsemblGenomes-Gn:BSU11920" /db_xref="EnsemblGenomes-Tr:CAB13049" /db_xref="SubtiList:BG13167" /db_xref="UniProtKB/Swiss-Prot:O31636" /translation="MKKKTKIILSLLAALIVILIVLPVLSPVVFTASSEKGAIRHEIY KRGYPYQSYFAVLQKREGDNESGNLYYVNWLDWKDETGQTPHLCYSKKSSDGEYEVSC GTGP*" gene 1265057..1265377 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" downshifts 1265387 /Source="Nicolas_upshifts" /id="D659" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="3.73892" /MaxDrop="4.41989" /score="26.2462772" /energy="-24.7" /TU="U969" /idTUdmin="U967" /TUdmin=886 /isTUend="FALSE" S_feature 1265432..1265529 /Source="Nicolas_S_feature" /locus_tag="new_1265432_1265529" /HighExp="LoTm, B60, Cold, B36, T3.30H, T3.0H, T4.0H, T2.0H, Sw, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S433" CDS 1265530..1265661 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097707.1" /db_xref="EnsemblGenomes-Gn:BSU11928" /db_xref="EnsemblGenomes-Tr:CAX52597" /db_xref="UniProtKB/Swiss-Prot:C0H3Z0" /translation="MKQSKKKPSQKQHERLDRFWQQMMNTNMQTLRRGKGGAYKRRK* " gene 1265530..1265661 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" CDS 1265677..1265850 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097708.1" /db_xref="EnsemblGenomes-Gn:BSU11929" /db_xref="EnsemblGenomes-Tr:CAX52598" /db_xref="UniProtKB/Swiss-Prot:C0H3Z1" /translation="MMKNGFAYKNGKLVNIFCGKEELYNELKAFLVKTFSINVKEVSR PSIYRRTKSKQLE*" gene 1265677..1265850 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" CDS 1265887..1266348 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative DNA binding protein; phage island" /protein_id="NP_389075.1" /db_xref="EnsemblGenomes-Gn:BSU11930" /db_xref="EnsemblGenomes-Tr:CAB13050" /db_xref="GOA:O31637" /db_xref="InterPro:IPR013324" /db_xref="SubtiList:BG13168" /db_xref="UniProtKB/Swiss-Prot:O31637" /translation="MTDQMIAWEIEEWIRDYKFMLREIKRLNRVLNKVDFISTKLTAT YGEEAGMPRGSAGVSQAELRQMDRRERRLHKYESIVHYLDNAMEHIEEEKHRIVYDCM MEGMSYTAIANHLDCSRDTIRKIKTAIIGNIVNKVKEANFLQYLNSFKSAV*" gene 1265887..1266348 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" promotor_-35 1266319..1266326 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-35" promotor_-10 1266341..1266360 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-10" S_feature 1266349..1266589 /Source="Nicolas_S_feature" /locus_tag="new_1266349_1266589" /HighExp="LoTm, B60, Cold, B36, Diami, S8, dia15, C30, dia5, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.12525800000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S434" upshifts 1266349 /Source="Nicolas_upshifts" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" promotor_-35 1266562..1266569 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1266583..1266601 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1266591 /Source="Nicolas_upshifts" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" CDS 1266614..1267117 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein: phage island" /protein_id="NP_389076.1" /db_xref="EnsemblGenomes-Gn:BSU11940" /db_xref="EnsemblGenomes-Tr:CAB13051" /db_xref="GOA:O31638" /db_xref="SubtiList:BG13169" /db_xref="UniProtKB/Swiss-Prot:O31638" /translation="MKKQKNNKKKNIEKRNIEKRNIEEKNNEDLEELENAIYTYHKKE LLAFFLEKTRIGHDKEEYKRFQSLLYKLDIECLEFAISRFSHIDIIHDHSKYVPAFIP LFAAYLTMFFNFYEKHWGALSFAAGTIAAIVWIIAVERKHRNQAISIMKIFEQVKERK VKDRSKD*" gene 1266614..1267117 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" CDS 1267129..1267413 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389077.1" /db_xref="EnsemblGenomes-Gn:BSU11950" /db_xref="EnsemblGenomes-Tr:CAB13052" /db_xref="InterPro:IPR018597" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HGC" /db_xref="SubtiList:BG13170" /db_xref="UniProtKB/Swiss-Prot:O31639" /translation="MNKDKLRYAILKEIFEGNTPLSENDIGVTEDQFDDAVNFLKREG YIIGVHYSDDRPHLYKLGPELTEKGENYLKENGTWSKAYKTIKEIKDWIK*" gene 1267129..1267413 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" downshifts 1267383 /Source="Nicolas_upshifts" /id="D660" /incds=0 /nref=215 /ntot=271 /MaxReadThrough="1.63272" /MaxDrop="7.26386" /score="22.0381158" /energy="-7.2" /TU="NA" /idTUdmin="U969" /TUdmin=0 /isTUend="TRUE" upshifts complement(1267415) /Source="Nicolas_upshifts" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(1267426..1267429) /Source="Nicolas_upshift_promotors" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1267574..1268101 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7489895, 7704261; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phage-related nucleic acid binding terminase small subunit; phage island" /protein_id="NP_389078.1" /db_xref="EnsemblGenomes-Gn:BSU11960" /db_xref="EnsemblGenomes-Tr:CAB13053" /db_xref="GOA:O31640" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010332" /db_xref="SubtiList:BG13171" /db_xref="UniProtKB/Swiss-Prot:O31640" /translation="MAEKHIQAYKDYVKGMKYKDLAEKYGVSVNTIKSWKQRHGWERK KGAPIEKSVHTKKGGQPGNKNALGNNGGAPQKNQNAVTHGFFSKFLPEETLEIMEEIQ ERSPADMIWDQIQIQYAAILRAQKIMFVSDKEEMIKELKKKRSLISEVSEIEDGLVIS FSTWFRYRLYSETNT*" gene 1267574..1268101 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" promotor_-35 1268248..1268253 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1268266..1268285 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1268269 /Source="Nicolas_upshifts" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" CDS 1268275..1268592 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389079.1" /db_xref="EnsemblGenomes-Gn:BSU11970" /db_xref="EnsemblGenomes-Tr:CAB13054" /db_xref="GOA:O31641" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:1Q8B" /db_xref="SubtiList:BG13172" /db_xref="UniProtKB/Swiss-Prot:O31641" /translation="MKSHKMMGGGISMHYITACLKIISDKDLNEIMKEFKKLEEETNK EEGCITFHAYPLEPSERKIMLWEIWENEEAVKIHFTKKHTIDVQKQELTEVEWLMKSN VND*" gene 1268275..1268592 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" S_feature 1268593..1268828 /Source="Nicolas_S_feature" /locus_tag="new_1268593_1268828" /HighExp="dia5, H2O2, dia15, dia0, Lbexp, Lbtran, C90, Oxctl, S1, aero" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S435" CDS 1268829..1269584 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2243795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-carrier protein oxidoreductase; phage island" /protein_id="NP_389080.1" /db_xref="EnsemblGenomes-Gn:BSU11980" /db_xref="EnsemblGenomes-Tr:CAB13055" /db_xref="GOA:O31642" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13173" /db_xref="UniProtKB/Swiss-Prot:O31642" /translation="MSHSQEKIALITGASSQGDIGTAICRKLASQGIHIFFTHWNSDT AWIEEFQQEILRMGVRCEAMKIDLSDAHAAFTIHEKISDKLGYPSILINNAAHSASDN YVSLDAKSLDEHYAVNMRSNFLLCVEFARRFKKSNLISGRIINMTSGQDLGPLPGELA YAATKGAISAFTRSLSQELAPLGITVNAVNPGPTDSTWMTDEIRNFLSPKFPMGRIGT PDDAARMIAFLASDEAEWITGQIIHSEGGFIRG*" gene 1268829..1269584 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" S_feature 1269585..1269672 /Source="Nicolas_S_feature" /locus_tag="new_1269585_1269672" /HighExp="C90, S1, dia0, dia5, Mt0, Lbexp, Gly, H2O2, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S436" downshifts 1269629 /Source="Nicolas_upshifts" /id="D661" /incds=0 /nref=89 /ntot=238 /MaxReadThrough="2.66489" /MaxDrop="5.39812" /score="-0.84766737" /energy="-14.2" /TU="NA" /idTUdmin="U974" /TUdmin="-20" /isTUend="TRUE" S_feature complement(1269672..1269732) /Source="Nicolas_S_feature" /locus_tag="new_1269672_1269732_c" /HighExp="Lbstat, BI, BT, nit, S2, ferm, B60, B36, M0t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S437" downshifts complement(1269703) /Source="Nicolas_upshifts" /id="D662" /incds=0 /nref=80 /ntot=134 /MaxReadThrough="1.9707" /MaxDrop="7.43843" /score="-5.56180712" /energy="-14.2" /TU="NA" /idTUdmin="U975" /TUdmin=0 /isTUend="TRUE" CDS complement(1269733..1270080) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16291680; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported protein; phage island" /protein_id="NP_389081.1" /db_xref="EnsemblGenomes-Gn:BSU11990" /db_xref="EnsemblGenomes-Tr:CAB13056" /db_xref="InterPro:IPR003343" /db_xref="InterPro:IPR008964" /db_xref="SubtiList:BG13174" /db_xref="UniProtKB/Swiss-Prot:O31643" /translation="MNFKKTVVSALSISALALSVSGVASAHEINSTPTEVKNISISPT HVIKIQDYNLPLKVGETYSVKNNSATRYWTDNQKVAEVDQNGLVTAKSKGKATITLFK GTAVFGKVYVTVY*" gene complement(1269733..1270080) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" promotor_-10 complement(1270112..1270130) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1270125) /Source="Nicolas_upshifts" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" S_feature complement(1270127..1270583) /Source="Nicolas_S_feature" /locus_tag="new_1270127_1270583_c" /HighExp="T1.30H, T2.0H, T2.30H, T3.0H, M9-stat, T1.0H, Lbstat, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S438" promotor_-35 complement(1270141..1270149) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1270543..1270561 /Source="Nicolas_upshift_promotors" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1270555 /Source="Nicolas_upshifts" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" promotor_-10 complement(1270561..1270580) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1270583) /Source="Nicolas_upshifts" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" promotor_-35 complement(1270594..1270601) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1270631..1272577 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10438772, 10960106, 23551403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438772, 10960106, 23551403; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional DNA-binding activator" /protein_id="NP_389082.2" /db_xref="EnsemblGenomes-Gn:BSU12000" /db_xref="EnsemblGenomes-Tr:CAB13057" /db_xref="GOA:O31644" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG13175" /db_xref="UniProtKB/Swiss-Prot:O31644" /translation="MEYINTRQKEILYLLLSEPDDYLVVQDFADRVQCSEKTIRNDLK VIEDYLNEHSHAQLIRKPGLGVYLHIEEQERTWLSQQLHTEHFSSRQRSDKERMLHIA YDLLMNPKPVSAKDIAARHFVNRSSIKKDLYAVEEWLKRFDLTLVSRQRLGLKVEGNE RNKRKALARISDLIHNTAFTSQFIKSKFLHYEVDFVTKEIKSLQKKHSLYFTDETFES LLLHTLLMVRRIKMKQPISLSPKEMAAVKKKKEYQWTFACLQRLEPVFAIRFPEEEAV YLTLHILGGKVRYPLQTEENLENAVLPKVVGHLINRVSELKMMDFHKDQDLINGLNIH LNTVLQRLSYDLSVANPMLNDIKKMYPYLFHLIIDVLEDINQTFDLHIPEEEAAYLTL HFQAAIERMQGSSETHKKAVIVCHMGIGMSQLLRTKIERKYHQIAVMACIAKADLKDY IKKHEDIDLVISTIALENITVPHIVVSPLLEPGEEKKLSAFIRQLGESHRQKQKTFQM LNNTTPFLVFLQQEAEHRYKLIEQLATALFEKGYVDKDYAVHAVMREKMSATNIGSGI AIPHANAKFIKQSAIAIATLKEPLEWGNEKVSLVFMLAVKHEDQTMTKQLFSELSYLS EQPAFVQKLTKETNVMTFLSHLDY*" gene 1270631..1272577 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" downshifts 1272553 /Source="Nicolas_upshifts" /id="D663" /incds=0 /nref=3 /ntot=35 /MaxReadThrough="4.64475" /MaxDrop="3.79938" /score="28.4199725" /energy="-9.1" /TU="U976" /idTUdmin="U976" /TUdmin="-110" /isTUend="FALSE" promotor_-35 1272653..1272656 /Source="Nicolas_upshift_promotors" /id="U978" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.936063936063936" /xcortree=1565 /SigmaFactorBS="tttattaccggaacctatggtaaaaaaagcGATTttaatgag ctgatttCGGTATACAGTTGAGACAAGatcttattattcacactttaaaggaggtttc c" /listShort="manP, manA, S439, S440, yjdF, yjdI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1272672..1272691 /Source="Nicolas_upshift_promotors" /id="U978" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.936063936063936" /xcortree=1565 /SigmaFactorBS="tttattaccggaacctatggtaaaaaaagcGATTttaatgag ctgatttCGGTATACAGTTGAGACAAGatcttattattcacactttaaaggaggtttc c" /listShort="manP, manA, S439, S440, yjdF, yjdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1272683 /Source="Nicolas_upshifts" /id="U978" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.936063936063936" /xcortree=1565 /SigmaFactorBS="tttattaccggaacctatggtaaaaaaagcGATTttaatgag ctgatttCGGTATACAGTTGAGACAAGatcttattattcacactttaaaggaggtttc c" /listShort="manP, manA, S439, S440, yjdF, yjdI" /GFF_Attribute="listLong" upshifts complement(1272695) /Source="Nicolas_upshifts" /id="U979" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.748251748251748" /psig="0.14985014985015" /xcortree=304 /SigmaFactorBS="tcggacaagatgtaatcgctaacagtttcataggaaaCCTCC TTTAAAGTGTgaataataagatcttgtctcaactgtataccgaaatcagctcattaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(1272704..1272718) /Source="Nicolas_upshift_promotors" /id="U979" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.748251748251748" /psig="0.14985014985015" /xcortree=304 /SigmaFactorBS="tcggacaagatgtaatcgctaacagtttcataggaaaCCTCC TTTAAAGTGTgaataataagatcttgtctcaactgtataccgaaatcagctcattaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1272725..1274677 /gene="manP" /locus_tag="BSU_12010" /old_locus_tag="BSU12010" /EC_number="2.7.1.191" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10627040, 10960106, 23551403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627040, 10960106, 23551403; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannose-specificenzyme IIBCA component" /protein_id="NP_389083.2" /db_xref="EnsemblGenomes-Gn:BSU12010" /db_xref="EnsemblGenomes-Tr:CAB13058" /db_xref="GOA:O31645" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR003353" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004715" /db_xref="InterPro:IPR006327" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="PDB:2R48" /db_xref="SubtiList:BG13176" /db_xref="UniProtKB/Swiss-Prot:O31645" /translation="MKLLAITSCPNGIAHTYMAAENLQKAADRLGVSIKVETQGGIGV ENKLTEEEIREADAIIIAADRSVNKDRFIGKKLLSVGVQDGIRKPEELIQKALNGDIP VYRSATKSESGNHQEKKQNPIYRHLMNGVSFMVPFIVVGGLLIAVALTLGGEKTPKGL VIPDDSFWKTIEQIGSASFSFMIPILAGYIAYSIADKPGLVPGMIGGYIAATGSFYDS ASGAGFLGGIIAGFLAGYAALWIKKLKVPKAIQPIMPIIIIPVFASLIVGLAFVFLIG APVAQIFASLTVWLAGMKGSSSILLALILGAMISFDMGGPVNKVAFLFGSAMIGEGNY EIMGPIAVAICIPPIGLGIATFLGKRKFEASQREMGKAAFTMGLFGITEGAIPFAAQD PLRVIPSIMAGSMTGSVIAMIGNVGDRVAHGGPIVAVLGAVDHVLMFFIAVIAGSLVT ALFVNVLKKDITASPVLSETAPTSAPSEAAAANEIKQPIQSQKAEMSEFKKLTDIISP ELIEPNLSGETSDDIIDELIQKLSRRGALLSESGFKQAILNREQQGTTAIGMNIAIPH GKSEAVREPSVAFGIKRSGVDWNSLDGSEAKLIFMIAVPKESGGNQHLKILQMLSRKL MDDNYRERLLSVQTTEEAYKLLEEIE*" gene 1272725..1274677 /gene="manP" /locus_tag="BSU_12010" /old_locus_tag="BSU12010" CDS 1274692..1275639 /gene="manA" /locus_tag="BSU_12020" /old_locus_tag="BSU12020" /EC_number="5.3.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960106, 7934877, 20862359, 23551403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960106, 7934877, 20862359, 23551403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannose-6 phosphate isomerase; cupin family" /protein_id="NP_389084.1" /db_xref="EnsemblGenomes-Gn:BSU12020" /db_xref="EnsemblGenomes-Tr:CAB13059" /db_xref="GOA:O31646" /db_xref="InterPro:IPR001250" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014628" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG13177" /db_xref="UniProtKB/Swiss-Prot:O31646" /translation="MTTEPLFFKPVFKERIWGGTALADFGYTIPSQRTGECWAFAAHQ NGQSVVQNGMYKGFTLSELWEHHRHLFGQLEGDRFPLLTKILDADQDLSVQVHPNDEY ANIHENGELGKTECWYIIDCQKDAEIIYGHNATTKEELTTMIERGEWDELLRRVKVKP GDFFYVPSGTVHAIGKGILALETQQNSDTTYRLYDYDRKDAEGKLRELHLKKSIEVIE VPSIPERHTVHHEQIEDLLTTTLIECAYFSVGKWNLSGSASLKQQKPFLLISVIEGEG RMISGEYVYPFKKGDHMLLPYGLGEFKLEGYAECIVSHL*" gene 1274692..1275639 /gene="manA" /locus_tag="BSU_12020" /old_locus_tag="BSU12020" S_feature 1275640..1275738 /Source="Nicolas_S_feature" /locus_tag="new_1275640_1275738" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, H2O2, dia5, Fru, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15168699999999999" /TUshortSig="SigA" /TUshortPSig="0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S439" promotor_-35 1275713..1275719 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1275734..1275753 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1275740..1275808 /Source="Nicolas_S_feature" /locus_tag="new_1275740_1275808" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, dia5, Fru, H2O2, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S440" upshifts 1275740 /Source="Nicolas_upshifts" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" CDS 1275809..1276291 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20139185" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389085.1" /db_xref="EnsemblGenomes-Gn:BSU12030" /db_xref="EnsemblGenomes-Tr:CAB13060" /db_xref="InterPro:IPR016787" /db_xref="SubtiList:BG13178" /db_xref="UniProtKB/Swiss-Prot:O31647" /translation="MSVTFPSSGCPSFFNIFYEEGIVMKLTIYYDGQFWVGVVEVVDN GKLRAFRHLFGKEPRDSEVLEFVHNQLLNMMAQAEQEGVRLQGRRQKKINPKRLQRQV SKELKNAGVTSKAQEAIKLELEARKQKKKQIMKEQREHVKEQRYMLKKQKAKKKHRGK *" gene 1275809..1276291 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" downshifts 1276271 /Source="Nicolas_upshifts" /id="D664" /incds=0 /nref=220 /ntot=267 /MaxReadThrough="5.32805" /MaxDrop="7.35641" /score="7.68574519" /energy="-10.2" /TU="U978" /idTUdmin="U980" /TUdmin=1 /isTUend="TRUE" CDS complement(1276337..1276843) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389086.1" /db_xref="EnsemblGenomes-Gn:BSU12040" /db_xref="EnsemblGenomes-Tr:CAB13061" /db_xref="GOA:O31648" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13179" /db_xref="UniProtKB/Swiss-Prot:O31648" /translation="MVLLETNRLRLQTIDIPLLDAASKQDHQAIKELGYETNGEWPNS DFFEAIPYFREILVKNNGTKGFDSWIIVKKDNYEIVGGTGFLGDPDENGMIEIGFATN KSHRRKGYCVEAAQKLINWALSRETVSRITARCEHDNLGSQKTLEKLGFILNHKSAEY KHWIYVTK*" gene complement(1276337..1276843) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" downshifts complement(1276361) /Source="Nicolas_upshifts" /id="D665" /incds=0 /nref=13 /ntot=154 /MaxReadThrough="2.51872" /MaxDrop="4.09551" /score="15.8830125" /energy="-9.9" /TU="NA" /idTUdmin="U984" /TUdmin=7 /isTUend="TRUE" misc_feature complement(1276868..1276887) /Source="Nicolas_upshift_promotors" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1276874) /Source="Nicolas_upshifts" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" S_feature complement(1276876..1277061) /Source="Nicolas_S_feature" /locus_tag="new_1276876_1277061_c" /HighExp="S5, S4, S7, S6, S8, B36, LoTm, S3, B60, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.289238" /TUshortSig="SigEF, SigWXY" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S441" CDS complement(1277062..1277457) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389087.2" /db_xref="EnsemblGenomes-Gn:BSU12050" /db_xref="EnsemblGenomes-Tr:CAB13062" /db_xref="SubtiList:BG13180" /db_xref="UniProtKB/Swiss-Prot:O31649" /translation="MYHYFYGPALIPYFSHTHNPQRSPDFSERQRRREITLTVDGFVP PSSTEDLGDGFYSYAWTNQQVINPGEYLVCHLEGRDINVINGGFTPRDTAPLYAVASF PRRRNQWVIIIHNPVQTQRAISLYLIAKR*" gene complement(1277062..1277457) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" promotor_-10 complement(1277480..1277498) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1277493) /Source="Nicolas_upshifts" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" S_feature complement(1277495..1278195) /Source="Nicolas_S_feature" /locus_tag="new_1277495_1278195_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, S0, T2.0H, Salt, T2.30H, T-1.10H" /AntisenseName="yjdI" /AntisenseCor="-0.383915151906285" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S442" promotor_-35 complement(1277513..1277518) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1277601..1277608 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1277622..1277641 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1277633 /Source="Nicolas_upshifts" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" CDS 1277686..1278165 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22128149; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cys-tRNApro deacetylase; tRNA editing" /protein_id="NP_389088.1" /db_xref="EnsemblGenomes-Gn:BSU12060" /db_xref="EnsemblGenomes-Tr:CAB13063" /db_xref="GOA:O31650" /db_xref="InterPro:IPR004369" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG13181" /db_xref="UniProtKB/Swiss-Prot:O31650" /translation="MAKKMAKTNAVRLIEQQNISYEVLGYKTDGQPVDGISVAEKIGY SLKYVYKTLVAAAGTNHYYVFVVPVAEELDVKKAAKVTGEKKIEMIAMKELLAVTGYL RGGCSPIGMKKLFPTYIDASAETLDFIIVSAGKIGMQLKLAPQDLARSCDAAFAEIV* " gene 1277686..1278165 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" downshifts 1278164 /Source="Nicolas_upshifts" /id="D666" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="2.68858" /MaxDrop="3.19616" /score="-5.52314972" /energy="-12.5" /TU="NA" /idTUdmin="U978" /TUdmin=0 /isTUend="TRUE" CDS complement(1278205..1278399) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097709.1" /db_xref="EnsemblGenomes-Gn:BSU12069" /db_xref="EnsemblGenomes-Tr:CAX52599" /db_xref="InterPro:IPR025234" /db_xref="UniProtKB/Swiss-Prot:C0H3Z2" /translation="MKEYEFVRVELSTMRRRPKEDYQQIIHDYAKRGWRFVQIFAPSI DGYGAAAYFEIIFERDAEKA*" gene complement(1278205..1278399) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" downshifts complement(1278240) /Source="Nicolas_upshifts" /id="D667" /incds=0 /nref=6 /ntot=144 /MaxReadThrough="7.83072" /MaxDrop="2.95935" /score="-6.07514027" /energy="-7" /TU="U984" /idTUdmin="U987" /TUdmin=220 /isTUend="FALSE" promotor_-10 complement(1278413..1278428) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1278429) /Source="Nicolas_upshifts" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" promotor_-35 complement(1278440..1278449) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1278565..1278894) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389089.1" /db_xref="EnsemblGenomes-Gn:BSU12070" /db_xref="EnsemblGenomes-Tr:CAB13064" /db_xref="GOA:O31651" /db_xref="InterPro:IPR016508" /db_xref="InterPro:IPR025440" /db_xref="SubtiList:BG13182" /db_xref="UniProtKB/Swiss-Prot:O31651" /translation="MKGIFLVVQLGFSIMVFLFLAAVNWYQGSELVSDRFDWNYTAKL SKLLNGIDAVSSPKQISQLDFFIYSAKHYPVMSALMIISFLYVLAALFLLIYSVKCNK QEIHLDC*" gene complement(1278565..1278894) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" promotor_-10 complement(1278931..1278950) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1278944) /Source="Nicolas_upshifts" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" S_feature complement(1278946..1279513) /Source="Nicolas_S_feature" /locus_tag="new_1278946_1279513_c" /HighExp="S8, S6, nit, S7, ferm, S2, S5, M9-tran, M/G, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.987, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S443" promotor_-35 complement(1278965..1278970) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1278998..1279002 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1279018..1279037 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1279022..1279523 /Source="Nicolas_S_feature" /locus_tag="new_1279022_1279523" /HighExp="LBGstat, C30, HPh, Oxctl, dia15, Paraq, T0.30H, C90, LBGtran, LPh" /AntisenseName="ctaO" /AntisenseCor="-0.43946575370083102" /AntisenseRegPval="-13.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S444" upshifts 1279022 /Source="Nicolas_upshifts" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" CDS complement(1279514..1280503) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10675592, 15491161, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10675592, 15491161, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor protoheme IX farnesyltransferase 1 (heme Osynthase)" /protein_id="NP_389090.2" /db_xref="EnsemblGenomes-Gn:BSU12080" /db_xref="EnsemblGenomes-Tr:CAB13065" /db_xref="GOA:O31652" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG13183" /db_xref="UniProtKB/Swiss-Prot:O31652" /translation="MQFWGRRLFLENTRDSAAISETKYIKASNRVTIYDFIKLAKPGI IISNSIAAFGGFWIAFASAEKTLTGLAFLMTMVTAMLGTAFVMASGTVYNNYFDRHMD AKMARTRSRASVTGKMPPAMILTYGSVLGIAGLAMLYSLNPLTAFLGLAAFIFYAIIY TVWVKRTSVWSTFVGSFPGAAPPLMGYCAVTGDFSMTAVLLYTIMFLWQPPHFWAIGI RRKEEYRAAGVPLLPVVKGNHVTKIKMMQYIAVLVPVTLLFPFSLGTGHISPFYFLAA LVLGGIWIKKSIKGFKTDDDVKWAKDMFVYSLIYFCLLFFIMMIDSFMMFLIR*" gene complement(1279514..1280503) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" promotor_-10 complement(1280504..1280523) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-10" upshifts complement(1280507) /Source="Nicolas_upshifts" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" promotor_-35 complement(1280537..1280542) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-35" CDS complement(1280626..1280874) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1391045, 1917883, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1391045, 1917883, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner coat)" /protein_id="NP_389091.2" /db_xref="EnsemblGenomes-Gn:BSU12090" /db_xref="EnsemblGenomes-Tr:CAB13066" /db_xref="GOA:P11863" /db_xref="SubtiList:BG10495" /db_xref="UniProtKB/Swiss-Prot:P11863" /translation="MDYPLNEQSFEQITPYDERQPYYYPRPRPPFYPPYYYPRPYYPF YPFYPRPPYYYPRPRPPYYPWYGYGGGYGGGYGGGYGY*" gene complement(1280626..1280874) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" downshifts complement(1280636) /Source="Nicolas_upshifts" /id="D668" /incds=0 /nref=37 /ntot=82 /MaxReadThrough="5.73194" /MaxDrop="6.23577" /score="25.0951218" /energy="-8.4" /TU="U989" /idTUdmin="U990" /TUdmin=2 /isTUend="TRUE" promotor_-35 1280870..1280874 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1280883..1280897 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1280892 /Source="Nicolas_upshifts" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1280899..1280918) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1280908) /Source="Nicolas_upshifts" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" promotor_-35 complement(1280932..1280941) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1280989..1280996 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1281003..1281022) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1281010..1281029 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1281012) /Source="Nicolas_upshifts" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" upshifts 1281023 /Source="Nicolas_upshifts" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" S_feature 1281024..1281127 /Source="Nicolas_S_feature" /locus_tag="new_1281024_1281127" /HighExp="Heat, T0.30H, T1.0H, ferm, Diami, dia5, T1.30H, M9-stat, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S445" promotor_-35 complement(1281036..1281043) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1281128..1282531 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 17878218, 22277649" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 17878218, 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid deacetylase" /protein_id="NP_389092.1" /db_xref="EnsemblGenomes-Gn:BSU12100" /db_xref="EnsemblGenomes-Tr:CAB13067" /db_xref="GOA:O34798" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR017219" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="SubtiList:BG13184" /db_xref="UniProtKB/Swiss-Prot:O34798" /translation="MLAKRIKWFHVLIAVVCVVGLIGFFHNHSLKKETVMNKVRTDSQ YGNVEIATLVNDGKTFNYAVNYPVFKNEKMDSALKRFAEKEVRQFQKETKDVDQEHTT KRNELNVDYKIVHYAKQTVAIVFNEYKYIGGAHGQTVKKTFNYDFSKQAFLSIDDIFK EDADYLHKLSLIAYHELKKNKDIAADDALLKEGTAPKKENFSRFAIKEDYIELYFDTY QVAAGYLGEQSIAIKKSLLKDILKEQYIDKAKNKNKIKEQKPKHEVISLPKEETVDPN QKVIALTFDDGPNPATTNQILDSLKKYKGHATFFVLGSRVQYYPETLIRMLKEGNEVG NHSWSHPLLTRLSVKEALKQINDTQDIIEKISGYRPTLVRPPYGGINDELRSQMKMDV ALWDVDPEDWKDRNKKTIVDRVMNQAGDGRTILIHDIYRTSADAADEIIKKLTDQGYQ LVTVSQLEEVKKQREAK*" gene 1281128..1282531 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" downshifts 1282520 /Source="Nicolas_upshifts" /id="D669" /incds=0 /nref=173 /ntot=238 /MaxReadThrough="1.38483" /MaxDrop="6.60322" /score="39.935002" /energy="-13.8" /TU="NA" /idTUdmin="U991" /TUdmin=0 /isTUend="TRUE" CDS complement(1282571..1283044) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389093.1" /db_xref="EnsemblGenomes-Gn:BSU12110" /db_xref="EnsemblGenomes-Tr:CAB13068" /db_xref="InterPro:IPR021224" /db_xref="SubtiList:BG13185" /db_xref="UniProtKB/Swiss-Prot:O34554" /translation="MKRLFMKASLVLFAVVFVFAVKGAPAKAETHAYDGKSPYYNDCA SSGSTKKSSNLVNASNQVIGVVELKFSSTCKTAWAKITMNNTLTSGYEANAEITRNTD GKRYNCDSAGGNGKAVAGQKSCYTPMVYDLDPRTSYAFGKYSGPNLNVWATTGSY*" gene complement(1282571..1283044) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" downshifts complement(1282575) /Source="Nicolas_upshifts" /id="D670" /incds=0 /nref=33 /ntot=176 /MaxReadThrough="2.25434" /MaxDrop="5.38548" /score="20.5383759" /energy="-13.8" /TU="NA" /idTUdmin="U992" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(1283066..1283084) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1283084) /Source="Nicolas_upshifts" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" promotor_-35 complement(1283099..1283104) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1283169..1283336) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389094.1" /db_xref="EnsemblGenomes-Gn:BSU12120" /db_xref="EnsemblGenomes-Tr:CAB13069" /db_xref="InterPro:IPR025906" /db_xref="SubtiList:BG13186" /db_xref="UniProtKB/Swiss-Prot:O34438" /translation="MDIPALSVAMHQASLAQNVNIALTKKRLDTAQQNADQTLKMIQH PTLGQTIDVKA*" gene complement(1283169..1283336) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" downshifts complement(1283172) /Source="Nicolas_upshifts" /id="D671" /incds=0 /nref=109 /ntot=232 /MaxReadThrough="3.53249" /MaxDrop="4.93218" /score="-9.08395816" /energy="-13.9" /TU="U993" /idTUdmin="U993" /TUdmin="-576" /isTUend="FALSE" promotor_-10 complement(1283348..1283366) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1283357) /Source="Nicolas_upshifts" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" promotor_-35 complement(1283379..1283386) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1283463..1284362 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389095.2" /db_xref="EnsemblGenomes-Gn:BSU12130" /db_xref="EnsemblGenomes-Tr:CAB13070" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13187" /db_xref="UniProtKB/Swiss-Prot:O34458" /translation="MNLVMEKTFEQYEKLFSMEEQKREDVFRYTMMRPFEKMWTAIQV PLKAKEPNGYDVIMAAKMLGYLDVRDAESGQKALQILKESHVSETAESALRQCIFFAE REQLRVNAKEIKFGLYIADPNKLQLQKGYCGFGGIPGFIHVWINPNSYNLPRIPSIIA HEFHHNVRFSYIDFHHGSVSVGDYLVIEGLAESFARELFGTERLGPWVTRFDHEDLQY SIDVINEVLDVKGFSEVSRYMFGDPIANDQGFKPAGLSAFAGYAVGYHAVQSFMNQHH ITISEATRLDAKTIISQCGLFST*" gene 1283463..1284362 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" CDS complement(1284371..1284769) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_389096.1" /db_xref="EnsemblGenomes-Gn:BSU12140" /db_xref="EnsemblGenomes-Tr:CAB13071" /db_xref="GOA:O35027" /db_xref="InterPro:IPR021257" /db_xref="SubtiList:BG13188" /db_xref="UniProtKB/Swiss-Prot:O35027" /translation="MKRNRWIYAVFTILIIGLGLGSRAFSSVLPDTLNTYLGDSLWAA MIFTGCGFLFRKLKTMITGIISLSFCFVIEFSQLYHAEWIDQIRDTSLGGLVLGYGFL WSDIEAYTIGIAACAAIELLVLGIKKRRCM*" gene complement(1284371..1284769) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" downshifts complement(1284401) /Source="Nicolas_upshifts" /id="D672" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.86089" /MaxDrop="2.52307" /score="23.8106216" /energy="-10.1" /TU="U994,U995" /idTUdmin="U995" /TUdmin="-243" /isTUend="FALSE" promotor_-10 complement(1284798..1284817) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1284817) /Source="Nicolas_upshifts" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" promotor_-35 complement(1284832..1284839) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1284870..1285445) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1580552" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389097.1" /db_xref="EnsemblGenomes-Gn:BSU12150" /db_xref="EnsemblGenomes-Tr:CAB13072" /db_xref="InterPro:IPR025453" /db_xref="PDB:4YGT" /db_xref="SubtiList:BG13189" /db_xref="UniProtKB/Swiss-Prot:O34960" /translation="MKKTMSAITAAAAVTSCFTGFGAASFSAPAKAAAQTNTLSENTN QSAAELVKNLYNTAYKGEMPQQAQGLTINKSTKGDVHAAFGEPERPVGGDNRFDLYHW NMGQPGYGFSYHKDMTISEIRYFGTGVERQLNLGGVTPEVLQKQLGPVNRVLTVPFTD EIDYVYDTGRYELHFVIGTDQTADHVNLKAK*" gene complement(1284870..1285445) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" downshifts complement(1284885) /Source="Nicolas_upshifts" /id="D673" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.38565" /MaxDrop="3.9021" /score="23.8106216" /energy="-10.1" /TU="U995" /idTUdmin="U995" /TUdmin="-727" /isTUend="FALSE" promotor_-10 complement(1285464..1285482) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1285479) /Source="Nicolas_upshifts" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" promotor_-35 complement(1285496..1285502) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1285520..1285526 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1285541..1285559 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1285542 /Source="Nicolas_upshifts" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" CDS 1285591..1288548 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" /EC_number="1.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdoenzyme; putative formate dehydrogenase" /protein_id="NP_389098.1" /db_xref="EnsemblGenomes-Gn:BSU12160" /db_xref="EnsemblGenomes-Tr:CAB13073" /db_xref="GOA:O34720" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG13190" /db_xref="UniProtKB/Swiss-Prot:O34720" /translation="MAGKKTITINGVEMEASEEQTVLQLLNNSSIEVPQVCYHPSLGP IETCDTCIVSINGELKRSCSAELKDGDVIDTLSPDVKKAQVIGMDKILYNHELYCTVC DYNNGGCEIHNTVKEMKINHQSIPFDHKPYHKDESHPFYRYDPDQCILCGRCVEACQD VQVTETLTIDWERKRPRVIWDNDVPINESSCVSCGHCSTVCPCNAMMEKGMEGEAGYL TGINNETLRPMIEITKGVETGYGSILAISDMESAMRDERIKKTKTVCTYCGVGCSFDV WTKGRDILKVEPQEEAPANGISTCVKGKFGWDFVNSEERLTKPLIREGDHFREAEWEE ALLLIASKFTELKEAFGPDSLAFITSSKCTNEESYLMQKLARGVIGTNNVDNCSRYCQ SPATAGLFRTVGYGGDSGSITDIAQADLVLIIGSNTSESHPVLSTRIKRAHKLRGQKV IVADIRKHEMAERSDLFVQPRAGSDIVWLNAIAKYLIENGKADERFLRERVNGRDEYV KSLAPYTLEYAEEKTGIDQETLIQMAEMIGQADSVCALWAMGVTQHIGGSDTSTAISN LLLVTGNYGKPGAGSYPLRGHNNVQGASDFGSMPDRLPGYEKVTDEQVRQKYERVWGV PLPKEPGMTNHEMIEKIHSGQLKAMYVKGEEMGLVDSNINHVHAAYEKLDFFVVQDIF LSRTAEFADVVLPASPSLEKEGTFTNTERRIQRLYQVFEPLGESKPDWQIIMEVANKL GAGWLYEHPADIMEEAAKLSPIYAGVTYERLEGYNSLQWPVNADGKDSPLLFTERFPF PDGKAILYPVQWTEPKEFGEEYDIHVNNGRLLEHFHEGNLTYKSKGISEKTPEVFLEI SPELAAERGIQDGTLVRLTSPFGNVKVKCLITDRVKGKEVYLPMNDSGEAAINLLTGS HADKDTDTPAYKETSAKMEILKHDGISPLPKINHRNGNPQPQIGVQVHKKWARKDYIF PGDAVKRGMGHNG*" gene 1285591..1288548 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" CDS 1288541..1289101 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389099.1" /db_xref="EnsemblGenomes-Gn:BSU12170" /db_xref="EnsemblGenomes-Tr:CAB13074" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13191" /db_xref="UniProtKB/Swiss-Prot:O34681" /translation="MAKAIKRIQKIEVTEEDQRKRDLREIEDALIDHKEAILETLHML GHMNERGVLPLLRGLFGQGDKVLDILVKKADTEETANTLKNLLLLFGTLGMLDVKQLE PLILKVNAGVASAVEQKNSEEKTGYFDIIRSLKDPEINKSITLLFSFLKGMGQDTKEL ERTTQPPEHQKHHQEPREKRGMNKRD*" gene 1288541..1289101 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" downshifts 1289094 /Source="Nicolas_upshifts" /id="D674" /incds=0 /nref=18 /ntot=84 /MaxReadThrough="5.25706" /MaxDrop="6.46184" /score="20.7921843" /energy="-15" /TU="U996" /idTUdmin="U996" /TUdmin="-819" /isTUend="FALSE" S_feature 1289139..1289257 /Source="Nicolas_S_feature" /locus_tag="new_1289139_1289257" /HighExp="Etha, Salt, Heat, S8, M9-stat, S7, LPhT, G135, C30, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S446" promotor_-35 1289235..1289238 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1289254..1289273 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1289259 /Source="Nicolas_upshifts" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" CDS 1289298..1289939 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389100.1" /db_xref="EnsemblGenomes-Gn:BSU12180" /db_xref="EnsemblGenomes-Tr:CAB13075" /db_xref="GOA:O34725" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="PDB:3CFU" /db_xref="SubtiList:BG13192" /db_xref="UniProtKB/Swiss-Prot:O34725" /translation="MKKVLLLLFVLTIGLALSACSQSSDASEKEKPKEKKSQEELEKE LDKELKKGGEPKTKKDDQIHKIGETFKAGHTNFTVNKVDRVQKGEYMNVGGAVNEETK TIKDDEERLIIEVTMENIGEDSISYNFIGFDLRDKNDQSVRPVFSIEEKGRILMGGTL VSGKKVTGVLSYVIPKGEQKHYTLVYNPFLADTNSSNTEERVKDDIDYLVKLD*" gene 1289298..1289939 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" downshifts complement(1289307) /Source="Nicolas_upshifts" /id="D675" /incds=0 /nref=7 /ntot=57 /MaxReadThrough="2.5769" /MaxDrop="3.81596" /score="-9.34186213" /energy="-3" /TU="NA" /idTUdmin="U998" /TUdmin=1386 /isTUend="FALSE" downshifts 1289912 /Source="Nicolas_upshifts" /id="D676" /incds=0 /nref=24 /ntot=186 /MaxReadThrough="4.29897" /MaxDrop="3.4683" /score="19.6571267" /energy="-17" /TU="U997" /idTUdmin="U996" /TUdmin="-1" /isTUend="TRUE" CDS 1290018..1290644 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" /EC_number="3.6.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12483591, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ADP-ribose pyrophosphatase" /protein_id="NP_389101.2" /db_xref="EnsemblGenomes-Gn:BSU12190" /db_xref="EnsemblGenomes-Tr:CAB13076" /db_xref="GOA:C0SPC3" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG13193" /db_xref="UniProtKB/Swiss-Prot:C0SPC3" /translation="MIKVQTKWLERAQRIRAIAQAGLAFSKDVYDRERYEELMKLSAE MMADYSEKDIEVITDLWQGEKGYPTPKADVRGAVFRENQILLVREKHDELWSLPGGFC EIGLSPAENVVKEIKEESGYDTEPSRLLAVLDSHKHSHPPQPYHYYKIFIACSMTDGQ GETGIETNHAAFFPEDRLPPLSPKRNTPSQLSMLFDFLRHPDKKTIFD*" gene 1290018..1290644 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" downshifts 1290646 /Source="Nicolas_upshifts" /id="D677" /incds=0 /nref=97 /ntot=202 /MaxReadThrough="0.597580000000001" /MaxDrop="6.62023" /score="12.2319602" /energy="-7" /TU="NA" /idTUdmin="U997" /TUdmin=7 /isTUend="TRUE" downshifts complement(1290649) /Source="Nicolas_upshifts" /id="D678" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.18907" /MaxDrop="3.31161" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=44 /isTUend="FALSE" CDS complement(1290675..1290953) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 14563871" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389102.1" /db_xref="EnsemblGenomes-Gn:BSU12200" /db_xref="EnsemblGenomes-Tr:CAB13077" /db_xref="SubtiList:BG13194" /db_xref="UniProtKB/Swiss-Prot:O34679" /translation="MAAQTDYKKQVVGILLSLAFVLFVFSFSERHEKPLVEGKKQENW HTVVDKASVKIYGSRLVEENKLKQKLGHKQADSILTLLKLANEKHITL*" gene complement(1290675..1290953) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" downshifts complement(1290693) /Source="Nicolas_upshifts" /id="D679" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="1.96302" /MaxDrop="5.98058" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1290982..1290993) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1290995..1291001) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1291001) /Source="Nicolas_upshifts" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" S_feature complement(1291003..1291419) /Source="Nicolas_S_feature" /locus_tag="new_1291003_1291419_c" /HighExp="S6, S7, S8, S5, BT, C30, Pyr, G/S, C90, B36" /AntisenseName="yjiB" /AntisenseCor="-0.25565388711625397" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S447" upshifts 1291171 /Source="Nicolas_upshifts" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" misc_feature 1291172..1291191 /Source="Nicolas_upshift_promotors" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1291189..1291343 /Source="Nicolas_S_feature" /locus_tag="new_1291189_1291343" /HighExp="BC, T5.0H, T4.0H, C90, Sw, T3.30H, Lbstat, Diami, dia5, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.995811" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S448" CDS 1291344..1292534 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25587700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25587700; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP109B1, monooxygenase" /protein_id="NP_389103.1" /db_xref="EnsemblGenomes-Gn:BSU12210" /db_xref="EnsemblGenomes-Tr:CAB13078" /db_xref="GOA:O34374" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:4RM4" /db_xref="SubtiList:BG13195" /db_xref="UniProtKB/Swiss-Prot:O34374" /translation="MNVLNRRQALQRALLNGKNKQDAYHPFPWYESMRKDAPVSFDEE NQVWSVFLYDDVKKVVGDKELFSSCMPQQTSSIGNSIINMDPPKHTKIRSVVNKAFTP RVMKQWEPRIQEITDELIQKFQGRSEFDLVHDFSYPLPVIVISELLGVPSAHMEQFKA WSDLLVSTPKDKSEEAEKAFLEERDKCEEELAAFFAGIIEEKRNKPEQDIISILVEAE ETGEKLSGEELIPFCTLLLVAGNETTTNLISNAMYSILETPGVYEELRSHPELMPQAV EEALRFRAPAPVLRRIAKRDTEIGGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIRR HPNPHIAFGHGIHFCLGAPLARLEANIALTSLISAFPHMECVSITPIENSVIYGLKSF RVKM*" gene 1291344..1292534 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" promotor_-10 complement(1291417..1291436) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1291419) /Source="Nicolas_upshifts" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" promotor_-35 complement(1291450..1291459) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1292557..1293735 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 24893262, 27444326; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyphenols TDP-rhamnosyltransferase, promiscuous" /protein_id="NP_389104.1" /db_xref="EnsemblGenomes-Gn:BSU12220" /db_xref="EnsemblGenomes-Tr:CAB13079" /db_xref="GOA:O34539" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG13196" /db_xref="UniProtKB/Swiss-Prot:O34539" /translation="MKKYHISMINIPAYGHVNPTLALVEKLCEKGHRVTYATTEEFAP AVQQAGGEALIYHTSLNIDPKQIREMMEKNDAPLSLLKESLSILPQLEELYKDDQPDL IIYDFVALAGKLFAEKLNVPVIKLCSSYAQNESFQLGNEDMLKKIREAEAEFKAYLEQ EKLPAVSFEQLAVPEALNIVFMPKSFQIQHETFDDRFCFVGPSLGERKEKESLLIDKD DRPLMLISLGTAFNAWPEFYKMCIKAFRDSSWQVIMSVGKTIDPESLEDIPANFTIRQ SVPQLEVLEKADLFISHGGMNSTMEAMNAGVPLVVIPQMYEQELTANRVDELGLGVYL PKEEVTVSSLQEAVQAVSSDQELLSRVKNMQKDVKEAGGAERAAAEIEAFMKKSAVPQ *" gene 1292557..1293735 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" CDS complement(1293776..1293964) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="YP_003097710.1" /db_xref="EnsemblGenomes-Gn:BSU12229" /db_xref="EnsemblGenomes-Tr:CAX52600" /db_xref="UniProtKB/Swiss-Prot:C0H3Z3" /translation="METKKEEYETKGYDTSIVYEFNEYPDARSGRCDNCDYTLFKSSV KGGKFLRECRRCGMKKNI*" gene complement(1293776..1293964) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" downshifts complement(1293792) /Source="Nicolas_upshifts" /id="D680" /incds=0 /nref=94 /ntot=231 /MaxReadThrough="-0.1433" /MaxDrop="5.1712" /score="13.0160925" /energy="-9.5" /TU="NA" /idTUdmin="U1001" /TUdmin=3 /isTUend="TRUE" promotor_-10 complement(1293990..1294009) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1293993) /Source="Nicolas_upshifts" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" promotor_-35 complement(1294023..1294029) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1294051..1294058 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1294073..1294092 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1294084 /Source="Nicolas_upshifts" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" promotor_-10 complement(1294099..1294118) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1294103) /Source="Nicolas_upshifts" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1294133..1294140) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1294138..1294950 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389105.1" /db_xref="EnsemblGenomes-Gn:BSU12230" /db_xref="EnsemblGenomes-Tr:CAB13080" /db_xref="GOA:O34394" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG13197" /db_xref="UniProtKB/Swiss-Prot:O34394" /translation="MGKGLLGKRVAIGGSRKTEEISTIIEKQGGIPVIRPLQGTVYLA EKQVEPDLRTFAEEKADWVIFTTGIGLETLVDMAEKIGLKDEFLQAIRQAKAACRGYK TLSALKKLGITPEASDEDGTTRGLIRSLEPHDFSGKTVMVQLHGEKAPALMAFLEEKG ASVLPILPYQHIPPEEETVERLCRELMNDEVDAVCFTTAIQVRSLFDFAKGRGYINEV KKVFEERAIAAAVGKVTAEALREEGITRLLAPEIERMGAMIVELAKYYEEKE*" gene 1294138..1294950 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" downshifts 1294929 /Source="Nicolas_upshifts" /id="D681" /incds=0 /nref=196 /ntot=254 /MaxReadThrough="3.61369" /MaxDrop="5.73094" /score="10.6328997" /energy="-14.5" /TU="U1002" /idTUdmin="U1002" /TUdmin="-22" /isTUend="TRUE" CDS complement(1294996..1295748) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_389106.1" /db_xref="EnsemblGenomes-Gn:BSU12240" /db_xref="EnsemblGenomes-Tr:CAB13081" /db_xref="GOA:O34684" /db_xref="InterPro:IPR005226" /db_xref="SubtiList:BG13198" /db_xref="UniProtKB/Swiss-Prot:O34684" /translation="MDYLSLSLTMIFVLIALFLSKSFKAGVEKDMIIATIRAAVQLLI IGYVLSLIFRGDHPVFILLMVLLMLAVAAQNVIKRKKNTIGSFWRVFAALAIVEIVTQ GILLSLHIIPLTARYVIPISGMVIGNSMVLSSLFLNRLNSEVGVRKEEIQLILSLGGT PKQSIQRILTSAMKMSMIPTLESQKTLGLVQLPGMMTGQILAGADPIQAVRFQLLIVF TTMASAALTCVILSVLTYPSLFTVHQQLKQNE*" gene complement(1294996..1295748) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" downshifts complement(1295005) /Source="Nicolas_upshifts" /id="D682" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="0.924970000000001" /MaxDrop="3.5673" /score="13.1058081" /energy="-12.8" /TU="NA" /idTUdmin="U1001" /TUdmin="-1210" /isTUend="FALSE" CDS complement(1295748..1296500) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389107.1" /db_xref="EnsemblGenomes-Gn:BSU12250" /db_xref="EnsemblGenomes-Tr:CAB13082" /db_xref="GOA:O34756" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13199" /db_xref="UniProtKB/Swiss-Prot:O34756" /translation="MEANDQTQNIPAISFRSVRKSYKQDGQTYDVLQDVTGDIQQGAI VAVLGPSGSGKSTLLSMCNLMRTPDSGEVNIYGKEVREWNVNELRRTAALAFQSAPVL DGTVRDNLSLVQRLHQSQLYSPEKLASLAGLPPELLDRSARDLSGGQRQRLSLARTLS NPSSILLLDEITSALDPVSALEIEELIKRQHQEKKWTVMWVTHNMEQAKRIADTIWFM ADGRLLEIAETDTFFSAPQHEAAKEFLKGGTR*" gene complement(1295748..1296500) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" CDS complement(1296620..1297594) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14627822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389108.1" /db_xref="EnsemblGenomes-Gn:BSU12260" /db_xref="EnsemblGenomes-Tr:CAB13083" /db_xref="GOA:O34428" /db_xref="InterPro:IPR032713" /db_xref="SubtiList:BG13200" /db_xref="UniProtKB/Swiss-Prot:O34428" /translation="MKAIVIGILASLFFAVTFILNRAMELSGGSWLWSSSLRFIFMVP FLCLIVIMRGTFTPLLLEMRKKPFYWIKWSFVGFVLFYAPITFAAAYGPGWLIAGTWQ ITIVAGVLLSPLFYVKQDMPGGPQLIRQKIPLVSLGTSVIILIGAALIQLQHAESLSG RMLLFSVLPVVIAAFAYPLGNRRMLEEYGGRLDTFQRVLGMTLASLPFWLILAAYGWW SDGLPTASQTVQSFIVAVSSGIIATVLFFWATDMVRDNPQKLAAVEATQSGEVIFALL GEIVLLSGVFPSLLSFAGLFIIIAGMMLHTFASQPRKPKKKAQSNLTA*" gene complement(1296620..1297594) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" downshifts complement(1296655) /Source="Nicolas_upshifts" /id="D683" /incds=0 /nref=1 /ntot=95 /MaxReadThrough="1.84381" /MaxDrop="2.54799" /score="4.80318278" /energy="-14.5" /TU="NA" /idTUdmin="U1004" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1297615..1297634) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1297641) /Source="Nicolas_upshifts" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" S_feature complement(1297643..1300149) /Source="Nicolas_S_feature" /locus_tag="new_1297643_1300149_c" /HighExp="Lbstat, S2, M0t90, nit, BT, M40t90, ferm, BC, C30, Gly" /AntisenseName="ndh" /AntisenseCor="-0.74506751931257098" /AntisenseRegPval="-48.1" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S449" promotor_-35 complement(1297649..1297656) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1297677..1297683 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1297698..1297716 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1297701 /Source="Nicolas_upshifts" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" CDS 1297726..1298223 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10704478" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; cupin family" /protein_id="NP_389109.1" /db_xref="EnsemblGenomes-Gn:BSU12270" /db_xref="EnsemblGenomes-Tr:CAB13084" /db_xref="GOA:O34612" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014500" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG13201" /db_xref="UniProtKB/Swiss-Prot:O34612" /translation="MERETQTYFFPDDGRIPNHPDFPLVVYQNALKDTGLAERIVTRH GWSNSWSGSVFPYHHYHSNTHEVLIALRREAVIQFGGEKGAAIPFKSGDAVVIPAGVG HKKLSSSPDFTVLGAYPGGVQYDMKTGKPNEREEAVKQIKQAALPANDPITGKREPLL EIWVK*" gene 1297726..1298223 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" S_feature 1298224..1298337 /Source="Nicolas_S_feature" /locus_tag="new_1298224_1298337" /HighExp="Etha, M9-stat, B60, Salt, Gly, LPhT, Heat, Sw, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S450" promotor_-35 1298317..1298321 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1298337..1298356 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1298339..1298611 /Source="Nicolas_S_feature" /locus_tag="new_1298339_1298611" /HighExp="LBGtran, dia5, Lbexp, LBGexp, dia0, HPh, aero, LPh, BMM, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S451" upshifts 1298339 /Source="Nicolas_upshifts" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" CDS 1298612..1299034 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16513748, 17015645, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389110.1" /db_xref="EnsemblGenomes-Gn:BSU12280" /db_xref="EnsemblGenomes-Tr:CAB13085" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13202" /db_xref="UniProtKB/Swiss-Prot:O34633" /translation="MPETIDQTNASVSQSQQDLIDQLLKPEVQESLTVLVDQLPKLTE LVNILTKSYDFAQSVATDEVLKSDTVGAITEILEPVKETAKEVAATAIEAKDRAEASN ETIGLFGLLRMLKDPQAQKLFRFANSYLEVMNERENQK*" gene 1298612..1299034 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" CDS 1299074..1300252 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" /EC_number="1.6.99.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6816592, 16513748, 17015645, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6816592, 16513748, 17015645, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH dehydrogenase" /protein_id="NP_389111.1" /db_xref="EnsemblGenomes-Gn:BSU12290" /db_xref="EnsemblGenomes-Tr:CAB13086" /db_xref="GOA:P80861" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13203" /db_xref="UniProtKB/Swiss-Prot:P80861" /translation="MSKHIVILGAGYGGVLSALTVRKHYTKEQARVTVVNKYPTHQII TELHRLAAGNVSEKAVAMPLEKLFKGKDIDLKIAEVSSFSVDKKEVALADGSTLTYDA LVVGLGSVTAYFGIPGLEENSMVLKSAADANKVFQHVEDRVREYSKTKNEADATILIG GGGLTGVELVGELADIMPNLAKKYGVDHKEIKLKLVEAGPKILPVLPDDLIERATASL EKRGVEFLTGLPVTNVEGNVIDLKDGSKVVANTFVWTGGVQGNPLVGESGLEVNRGRA TVNDFLQSTSHEDVFVAGDSAVYFGPDGRPYPPTAQIAWQMGELIGYNLFAYLEGKTL ETFKPVNSGTLASLGRKDAVAIIGANSTPLKGLPASLMKEASNVRYLTHIKGLFSLAY *" gene 1299074..1300252 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" promotor_no_box 1300083..1300183 /Source="Nicolas_upshift_promotors" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(1300141..1300159) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1300143 /Source="Nicolas_upshifts" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(1300149) /Source="Nicolas_upshifts" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" promotor_-35 complement(1300171..1300179) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1300251 /Source="Nicolas_upshifts" /id="D684" /incds=0 /nref=220 /ntot=278 /MaxReadThrough="2.01042" /MaxDrop="8.69373" /score="30.6421047" /energy="-23.1" /TU="NA" /idTUdmin="U1005" /TUdmin="-2" /isTUend="TRUE" promotor_-35 1300360..1300367 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1300382..1300401 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1300407 /Source="Nicolas_upshifts" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" CDS 1300450..1301871 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" /EC_number="5.3.1.12" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galacturonate isomerase" /protein_id="NP_389112.1" /db_xref="EnsemblGenomes-Gn:BSU12300" /db_xref="EnsemblGenomes-Tr:CAB13087" /db_xref="GOA:O34808" /db_xref="InterPro:IPR003766" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13204" /db_xref="UniProtKB/Swiss-Prot:O34808" /translation="MEPFMGKNFLLKNETAVSLYHNYAKDMPIIDYHCHLSPKEIYEN KTFQNITEAWLYGDHYKWRIMRANGIEETYITGDAPDEEKFMAWAKTVPMAIGNPLYN WTHLELQRFFGIYEILNEKSGSAIWKQTNKLLKGEGFGARDLIVKSNVKVVCTTDDPV DSLEYHLLLKEDKDFPVSVLPGFRPDKGLEINREGFPEWVQALEDAAAISITTYDEFL KALEKRVRFFHSAGGRVSDHAIDTMVFAETTKEEAGRIFSDRLQGTEVSCEDEKKFKT YTLQFLCGLYAELDWAMQFHINALRNTNTKMMKRLGPDTGYDSMNDEEIAKPLYKLLN SVEMKNQLPKTILYSLNPNDNYVIASMINSFQDGITPGKIQFGTAWWFNDTKDGMLDQ MKALSNVGLFSRFIGMLTDSRSFLSYTRHEYFRRIVCNLIGEWVENGEVPRDMELLGS IVQGICYDNAKHYFQFQEEKANV*" gene 1300450..1301871 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" CDS 1301939..1303318 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+:altronate/mannonate symporter" /protein_id="NP_389113.1" /db_xref="EnsemblGenomes-Gn:BSU12310" /db_xref="EnsemblGenomes-Tr:CAB13088" /db_xref="GOA:O34961" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13205" /db_xref="UniProtKB/Swiss-Prot:O34961" /translation="MRTELANKVVSVETEKRLSLKEKMSYGFGDFGNGFMFDLGQIYL LKYFTDVAGIPAAMAGGIFLVSKLFAAITDPIVGSSIDYRKNIGKRGKFRPYLLIGSI VLAVLTVLIFLSPNVSTTGKLIYAYASYMIWGIGYSFVNIPYGSLGAAMTQNSEDRTS ISTFRQIGSLGALFITSVAVMPLLVKFDNPKVGYPVVMGLFAALGVFWFYICYRNCKE RIIISEAPKEKLTLSSVVKTFITNKPLLTLVLMTIFSISAYNIKSAMLVYFAQYNLGN VELMAYMNFIIIGSSFLGVVFLPKLVKMFGKKRTAMIGFGISVAADLINFMLPSNVYV FTILASIAFIGISIPNGITWALVSDIIDYGEWKSGERKEATTYSLFNFSRKLAQSLSG FLSGIGLGIIGYVPNAVQTAQALIGIKALLLLYPAIALALAMFIIGFLYKLTDQQHAQ IVQDLHQKS*" gene 1301939..1303318 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" promotor_-10 complement(1302458..1302477) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1302463) /Source="Nicolas_upshifts" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1302491..1302498) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1303343 /Source="Nicolas_upshifts" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" misc_feature 1303353..1303360 /Source="Nicolas_upshift_promotors" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1303355..1303422 /Source="Nicolas_S_feature" /locus_tag="new_1303355_1303422" /HighExp="S4, S5, S6, S3, S8, S7, T5.0H, T4.0H, T3.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S452" CDS 1303423..1304436 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655, 16788182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389114.1" /db_xref="EnsemblGenomes-Gn:BSU12320" /db_xref="EnsemblGenomes-Tr:CAB13089" /db_xref="GOA:O34736" /db_xref="InterPro:IPR003767" /db_xref="InterPro:IPR036111" /db_xref="SubtiList:BG13206" /db_xref="UniProtKB/Swiss-Prot:O34736" /translation="MKTITIAAEEAKELVWQKLDGAGLNERDAEKVADVLVHADLRNV HSHGVLHTEHYVNRLLAGGINPGAQPVFKETGPVTGVLDGDDGFGHVNCDMAMDHAID MAKKKGVGMVTAVNSSHCGALSYFVQKAADEKLIGMAMTHTDSIVVPFGGRTPILGTN PIAYGVPAKHKKPFILDMATSKVAFGKILQAREEGKEIPEGWGVDENGEAVTDPDKVV SLSTFGGPKGYGLSIVVDVFSGLLAGAAFGPHIAKMYNGLDQKRKLGHYVCAINPSFF TDWDTFLEQMDAMIDELQQSPPAVGFERVYVPGEIEQLHEERNKKNGISIARSVYEFL KSR*" gene 1303423..1304436 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" CDS 1304442..1305461 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389115.1" /db_xref="EnsemblGenomes-Gn:BSU12330" /db_xref="EnsemblGenomes-Tr:CAB13090" /db_xref="GOA:O35045" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13207" /db_xref="UniProtKB/Swiss-Prot:O35045" /translation="MKAVQVRKAYDLVTAEVKKPVLSKDDEVLVKVKRVGICGSDMHI YHGTNPLATLPRVIGHEVTGQVEAVGANVQSLKPGDHVVIEPISYCGSCYACRKGRPN VCAKLSVFGVHEDGGMREYIVLPERQLHAVSKDLPWEEAVMAEPYTIGAQAVWRGQVE KGDTVLIQGAGPIGICVLKMAKLAGAAVMMTDLNNERLAFAKENGADAVVNVQAEHVA ERVLEWTGNEGANVVIDAVCLPETFALSIEAVSPAGHVVVLGFDERAAQISQLPITKK EVTITGSRLQTNQFPKVVELLNGGRLMHNGLVTHTFSVDDVHHAFQFIKEHPDQVRKA VITFD*" gene 1304442..1305461 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" CDS 1305486..1306565 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" /EC_number="4.2.1.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9579062, 9882655, 10368143, 25145794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-mannonate dehydratase" /protein_id="NP_389116.1" /db_xref="EnsemblGenomes-Gn:BSU12340" /db_xref="EnsemblGenomes-Tr:CAB13091" /db_xref="GOA:O34346" /db_xref="InterPro:IPR004628" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG13208" /db_xref="UniProtKB/Swiss-Prot:O34346" /translation="MNMTFRWYGRGNDTVTLEYVKQIPGVKGIVWALHQKPVGDVWEK EEIRAETEYIQSYGFHAEVVESVNVHEAIKLGNEERGRYIENYKQTIRNLAGFGVKVI CYNFMPVFDWTRTDMFRPLEDGSTALFFEKAKVESLDPQELIRTVEEASDMTLPGWEP EKLARIKELFAAYRTVDEEKLWDNLSFFLQEILPVAEAYGVQMAIHPDDPPWPIFGLP RIITGEASYKKLRAISDSPSNCITLCTGSMGANPANDMVEIAKTYAGIAPFSHIRNVK IYENGDFIETSHLTKDGSINIQGVMEELHKQDYEGYVRPDHGRHLWGEQCRPGYGLYD RALGIMYLNGLWDAYEAMAKKEVGI*" gene 1305486..1306565 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" CDS 1306562..1307398 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" /EC_number="1.1.1.57" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructuronate reductase" /protein_id="NP_389117.1" /db_xref="EnsemblGenomes-Gn:BSU12350" /db_xref="EnsemblGenomes-Tr:CAB13092" /db_xref="GOA:O34896" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13209" /db_xref="UniProtKB/Swiss-Prot:O34896" /translation="MIPLHENLAGKTAVITGGSGVLCSAMARELARHGMKVAILNRTA EKGQAVVKEITAAGGTACAVAADVLDRMSLERAKEDILGQFGAVDLLINGAGGNHPDA ITDVETYEEAGEGQSFFDMDERGFLTVFSTNFTGAFLASQVFGKELLKADSPAIINLS SMSAYSPMTKVPAYSAAKASINNFTMWMAVHFAETGLRVNAIAPGFFLTKQNHDLLIN QDGTFTSRSHKIIAGTPMKRFGKPEDLLGTLLWLADESYSGFVTGITVPVDGGFMAYS GV*" gene 1306562..1307398 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" CDS 1307446..1308714 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8320243, 9579062, 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="hexuronate transporter" /protein_id="NP_389118.1" /db_xref="EnsemblGenomes-Gn:BSU12360" /db_xref="EnsemblGenomes-Tr:CAB13093" /db_xref="GOA:O34456" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13210" /db_xref="UniProtKB/Swiss-Prot:O34456" /translation="MFSKDKLPVILFLFLAGVINYLDRSALSIAAPFIQDDLTLSATQ MGLIFSSFSIGYAIFNFLGGVASDRYGAKLTLFVAMVVWSLFSGAVALAFGFVSLLII RILFGMGEGPLSATINKMVNNWFPPTQRASVIGVTNSGTPLGGAISGPIVGMIAVAFS WKVSFVLIMIIGLIWAVLWFKFVKEKPQETIKEAPAIKAETSPGEKIPLTFYLKQKTV LFTAFAFFAYNYILFFFLTWFPSYLVDERGLSVESMSVITVIPWILGFIGLAAGGFVS DYVYKKTARKGVLFSRKVVLVTCLFSSAVLIGFAGLVATTAGAVTLVALSVFFLYLTG AIYWAVIQDVVDQNNVGSVGGFMHFLANTAGIIGPALTGFIVDQTGTFSGAFLLAGGL AVFASLAVIRFVRPIIGKPAGTEAENPVSY*" gene 1307446..1308714 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" promotor_-35 1308658..1308661 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1308677..1308681 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1308679 /Source="Nicolas_upshifts" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" misc_feature 1308747..1308766 /Source="Nicolas_upshift_promotors" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1308747 /Source="Nicolas_upshifts" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" CDS 1308802..1309803 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9579062, 9882655" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9579062, 9882655; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_389119.1" /db_xref="EnsemblGenomes-Gn:BSU12370" /db_xref="EnsemblGenomes-Tr:CAB13094" /db_xref="GOA:Q9JMQ1" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13211" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ1" /translation="MVTIKDIAKLANVSHTTVSRALNNSPYIKEHTKKKILELAEQLN YTPNVNAKSLAMQKSHTIGLFFTSITNGTSHSFFADTIKGVNQAISEDYNLYVRGIDD LKNYDSVTPMRYDGIILMSQSDIDNSFIYHIREKNIPLVVLNRDIDDRTITNILSNDK EGSQEAVEYFIQSGHQDIAIIEGIEGFKSSQQRKEGYLSALIQHHIPIKHEYSVKGQY DMESGFQAMERLLALPNPPTAVFCSNDDMAIGAMNAIFAKGLRVPDDISVIGFDDIGF SQYITPRLSTVKRPVEKISVLGAQKLLSLISEPETKAEKILENTEFMVRDSVRRLTT* " gene 1308802..1309803 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" promotor_no_box complement(1309485..1309585) /Source="Nicolas_upshift_promotors" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1309525) /Source="Nicolas_upshifts" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1309779 /Source="Nicolas_upshifts" /id="D685" /incds=0 /nref=2 /ntot=132 /MaxReadThrough="2.47166" /MaxDrop="3.11543" /score="12.2153519" /energy="-7.4" /TU="NA" /idTUdmin="U1011" /TUdmin=0 /isTUend="TRUE" CDS 1309880..1311322 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" /EC_number="1.1.1.58" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tagaturonate reductase (altronate oxidoreductase)" /protein_id="NP_389120.1" /db_xref="EnsemblGenomes-Gn:BSU12380" /db_xref="EnsemblGenomes-Tr:CAB13095" /db_xref="GOA:O34354" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023668" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13212" /db_xref="UniProtKB/Swiss-Prot:O34354" /translation="MQKLNKNVYDHYTQYPEKILQFGEGNFLRGFIDWQIDQLNQHTD FNGSVAVVQPRGSEKIKRLNEQDGLYTLFLQGMKDGEAVNEHMIINSISRGIDLFSDY EAYKELASSERLRFIISNTTEAGIVCDEKDRLEDRPQKTFPGKLTAFLYFRYQAFKGD QTKGCVLIPCELIENNGEKLRETVLHYAHLWKLEEGFTQWIHEANTFCNSLVDRIVPG FPVDSIDEITADLGYQDDLIVVGEQYYLWVIEGPDWIGKELPFAAAGLHTKIVSDLTP YRTKKVRILNGAHTAMTPVALLYGLKTVRDAVEHPEVGRFIRELIDDEILPVLKMEGL SQYADDVLNRFKNPYIKHYLESIALNAISKFKTRNLPTLKEYAEQKGQLPERLVFSFS ALLYFYHDNETLQDDPAVLQFFKEVWCQEDGDMLRIASRVLGEQRLWGADLNEIPKLT DRVAVYLNHIHELGMQRALEQYCIQGGEVR*" gene 1309880..1311322 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" CDS 1311319..1312812 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" /EC_number="4.2.1.7" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="altronate dehydratase" /protein_id="NP_389121.2" /db_xref="EnsemblGenomes-Gn:BSU12390" /db_xref="EnsemblGenomes-Tr:CAB13096" /db_xref="GOA:O34673" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="SubtiList:BG13213" /db_xref="UniProtKB/Swiss-Prot:O34673" /translation="MKSFIKIHKQDNVLLALRDIQKGERLHAYGVSIEVKDDIKRGHK IALQSIKENDSIVKYGFPIGHASQDISIGEHIHVHNTKTNLSDIQLYSYTPRFDENPY SNENRTFKGFRRENGDAGVRNELWIVPTVGCVNGIAEKMLQRFVRETGDIAPFDNVLV LKHQYGCSQLGDDHENTKQILLNAIRHPNAGGVLVLGLGCENNELARMKEALQDVNLK RVKFLESQSVTDEMEAGVALLKEIHEAAKGDKREDIPLSELKIGLKCGGSDGFSGITA NPLLGRFSDYLIAQGGSTVLTEVPEMFGAETILMQRAANEEVFHKIVDLINDFKQYFI KHDQPVYENPSPGNKAGGISTLEDKSLGCTQKAGISPVTDVLKYGEVLKTKGLTLLSA PGNDLIASSALAAAGCQIVLFTTGRGTPFGTFVPTVKVATNTELYEAKPHWIDFNAGL LAEDDVHEEYVLREFIHYMIEVASGQLVNHEKNDFKELAIFKSGVTL*" gene 1311319..1312812 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" CDS complement(1312851..1313615) /gene="yjnA" /locus_tag="BSU_12400" /old_locus_tag="BSU12400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389122.1" /db_xref="EnsemblGenomes-Gn:BSU12400" /db_xref="EnsemblGenomes-Tr:CAB13097" /db_xref="GOA:O34578" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13214" /db_xref="UniProtKB/Swiss-Prot:O34578" /translation="MSVSIILMGLFVGALVGLTGVGGAALLTPLLIVLGINPSIAVGT DLVYNSITKLFGVASHWRQKTINFKLVKYLAIGSIPSASLAIGILHLFPAFHQHQEEI IKHALGYVLTLVAISIIVRLFLDRKLRPNRWQLMPLENKRALTILIGVVFGFIVGLTS IGSGSLFAIAMIYLFNMKASQIVGTDIAHAFLLVTAAGILNASFGSVDYMLAANLLLG SIPGVLIGSHLSPRFSPRPLQFIMASIILVSGLKLI*" gene complement(1312851..1313615) /gene="yjnA" /locus_tag="BSU_12400" /old_locus_tag="BSU12400" downshifts complement(1312870) /Source="Nicolas_upshifts" /id="D686" /incds=0 /nref=96 /ntot=170 /MaxReadThrough="1.34004" /MaxDrop="4.60564" /score="6.47747687" /energy="-11.3" /TU="NA" /idTUdmin="U1015" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(1313644..1313663) /Source="Nicolas_upshift_promotors" /id="U1015" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.378621378621379" /psig="0.995004995004995" /xcortree=1735 /SigmaFactorBS="aatttcaagcaactaacgtgcaaaaattcaaaaaatttAATT GATtaacgcgtcctaaTCATATATAATCTGATAAAAatagtcgggttttcaggaggcc t" /listShort="yjnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1313661) /Source="Nicolas_upshifts" /id="U1015" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.378621378621379" /psig="0.995004995004995" /xcortree=1735 /SigmaFactorBS="aatttcaagcaactaacgtgcaaaaattcaaaaaatttAATT GATtaacgcgtcctaaTCATATATAATCTGATAAAAatagtcgggttttcaggaggcc t" /listShort="yjnA" /GFF_Attribute="listLong" S_feature complement(1313663..1313744) /Source="Nicolas_S_feature" /locus_tag="new_1313663_1313744_c" /HighExp="S6, S8, S7, S5, BT, G/S, B36, Pyr, B60, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S453" promotor_-35 complement(1313677..1313683) /Source="Nicolas_upshift_promotors" /id="U1015" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.378621378621379" /psig="0.995004995004995" /xcortree=1735 /SigmaFactorBS="aatttcaagcaactaacgtgcaaaaattcaaaaaatttAATT GATtaacgcgtcctaaTCATATATAATCTGATAAAAatagtcgggttttcaggaggcc t" /listShort="yjnA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1313727..1313746) /Source="Nicolas_upshift_promotors" /id="U1016" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1284 /SigmaFactorBS="cttttttttgcgcctttagtacttctcgatttcgtCCAGACA CTCattatagggcaaaTGAATAGAGATATTGAGCATaccaaaatttcaagcaactaac g" /listShort="S453, yjnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1313744) /Source="Nicolas_upshifts" /id="U1016" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1284 /SigmaFactorBS="cttttttttgcgcctttagtacttctcgatttcgtCCAGACA CTCattatagggcaaaTGAATAGAGATATTGAGCATaccaaaatttcaagcaactaac g" /listShort="S453, yjnA" /GFF_Attribute="listLong" promotor_-35 complement(1313760..1313769) /Source="Nicolas_upshift_promotors" /id="U1016" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1284 /SigmaFactorBS="cttttttttgcgcctttagtacttctcgatttcgtCCAGACA CTCattatagggcaaaTGAATAGAGATATTGAGCATaccaaaatttcaagcaactaac g" /listShort="S453, yjnA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1313837) /Source="Nicolas_upshifts" /id="D687" /incds=0 /nref=192 /ntot=236 /MaxReadThrough="2.6067" /MaxDrop="6.40442" /score="13.4353262" /energy="-7.4" /TU="NA" /idTUdmin="U1017" /TUdmin=0 /isTUend="TRUE" CDS complement(1313840..1314304) /gene="yjoA" /locus_tag="BSU_12410" /old_locus_tag="BSU12410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20497499; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative DNA-binding protein" /protein_id="NP_389123.1" /db_xref="EnsemblGenomes-Gn:BSU12410" /db_xref="EnsemblGenomes-Tr:CAB13098" /db_xref="GOA:O34334" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="PDB:3DKA" /db_xref="SubtiList:BG13215" /db_xref="UniProtKB/Swiss-Prot:O34334" /translation="MCQSNQIVSHFLSHRNVTNELAEKISKDHYSYKPAETSMSAEEL VKHILTSFHLFANVIKEGNASPFQNKQEETETDLNVLAKTYTEKTVAILEQLTEEQLD REIDLTSAFGRKVTGRALLQLAMEHEIHHKGNLFVYVREMGHTELPFYQQRM*" gene complement(1313840..1314304) /gene="yjoA" /locus_tag="BSU_12410" /old_locus_tag="BSU12410" promotor_-10 complement(1314336..1314355) /Source="Nicolas_upshift_promotors" /id="U1017" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.985014985014985" /xcortree=1796 /SigmaFactorBS="ttgacatagcattttgtttcatcccacagcatatTACTTGTG aattcataaccgtTGATATAGGATTTCATTGCAccatttatttttacatatggaggag a" /listShort="yjoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1314350) /Source="Nicolas_upshifts" /id="U1017" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.985014985014985" /xcortree=1796 /SigmaFactorBS="ttgacatagcattttgtttcatcccacagcatatTACTTGTG aattcataaccgtTGATATAGGATTTCATTGCAccatttatttttacatatggaggag a" /listShort="yjoA" /GFF_Attribute="listLong" promotor_-35 complement(1314369..1314376) /Source="Nicolas_upshift_promotors" /id="U1017" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.985014985014985" /xcortree=1796 /SigmaFactorBS="ttgacatagcattttgtttcatcccacagcatatTACTTGTG aattcataaccgtTGATATAGGATTTCATTGCAccatttatttttacatatggaggag a" /listShort="yjoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1314390..1314399 /Source="Nicolas_upshift_promotors" /id="U1018" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1674 /SigmaFactorBS="tcaacggttatgaattcacaagtaatatgctgtgggaTGAAA CAAAAtgctatgtcaaTCGTATATATAACGTTcacaaaacatgaaatggagtataaac a" /listShort="yjoB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1314411..1314426 /Source="Nicolas_upshift_promotors" /id="U1018" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1674 /SigmaFactorBS="tcaacggttatgaattcacaagtaatatgctgtgggaTGAAA CAAAAtgctatgtcaaTCGTATATATAACGTTcacaaaacatgaaatggagtataaac a" /listShort="yjoB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1314413 /Source="Nicolas_upshifts" /id="U1018" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1674 /SigmaFactorBS="tcaacggttatgaattcacaagtaatatgctgtgggaTGAAA CAAAAtgctatgtcaaTCGTATATATAACGTTcacaaaacatgaaatggagtataaac a" /listShort="yjoB" /GFF_Attribute="listLong" CDS 1314453..1315724 /gene="yjoB" /locus_tag="BSU_12420" /old_locus_tag="BSU12420" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14757246" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14757246; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="informational ATPase possibly involved in protein degradation" /protein_id="NP_389124.1" /db_xref="EnsemblGenomes-Gn:BSU12420" /db_xref="EnsemblGenomes-Tr:CAB13099" /db_xref="GOA:O34703" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13216" /db_xref="UniProtKB/Swiss-Prot:O34703" /translation="MTNIPFIYQYEEKENERAAAGYGTFGYLITRIEETLYDQYGVFY ELYASDDPNTEYWELLVEDVRSGSLEPEHVAYIFEKLEKKTFAYDEDEKEPDYTVHKS IRNSVYAYPEKGVAFARIPYFQDGSIMSFDCLFAVNDEKMRAFLEGVRPRLWEKSKRK VTVFTDGDGGTSREQEAIVREVQRSQVIMNPLLKKEIYRSIDQFFHSDKSFYQTYDIP YKRGILLYGPPGNGKTTLVKSIAGSIDAPVAYWQITEFTSSETIEEVFQAARRLAPAV LVIEDIDSMPEDVRSFFLNTLDGATSKEGLFLIGTTNYPEEIDPGLMNRAGRFDRAYE IGLPDEELRLEYMKMRGFGIFLSEGEIKNAAKLTEGFSFAQLGELYVSSALQWHQEGN HHIETMVKDMTGEQRKSQRGSWMERNKVGFH*" gene 1314453..1315724 /gene="yjoB" /locus_tag="BSU_12420" /old_locus_tag="BSU12420" downshifts 1315697 /Source="Nicolas_upshifts" /id="D688" /incds=0 /nref=31 /ntot=186 /MaxReadThrough="2.4959" /MaxDrop="3.90459" /score="20.8794231" /energy="-13" /TU="NA" /idTUdmin="U1018" /TUdmin=0 /isTUend="TRUE" promotor_-35 1315803..1315810 /Source="Nicolas_upshift_promotors" /id="U1019" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig="0.998001998001998" /xcortree=469 /SigmaFactorBS="ttgcggttagccgaaattcgacaattgcggttattttgcgTT CTTCTTtttcttgtaaaTATGATAAAATATGACATATctcgggtaattcaaaaggggg g" /listShort="rapA, phrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1315822..1315841 /Source="Nicolas_upshift_promotors" /id="U1019" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig="0.998001998001998" /xcortree=469 /SigmaFactorBS="ttgcggttagccgaaattcgacaattgcggttattttgcgTT CTTCTTtttcttgtaaaTATGATAAAATATGACATATctcgggtaattcaaaaggggg g" /listShort="rapA, phrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1315823 /Source="Nicolas_upshifts" /id="U1019" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig="0.998001998001998" /xcortree=469 /SigmaFactorBS="ttgcggttagccgaaattcgacaattgcggttattttgcgTT CTTCTTtttcttgtaaaTATGATAAAATATGACATATctcgggtaattcaaaaggggg g" /listShort="rapA, phrA" /GFF_Attribute="listLong" upshifts complement(1315846) /Source="Nicolas_upshifts" /id="U1020" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.001998001998002" /xcortree=720 /SigmaFactorBS="ccgacataagaggacggaatcgtctgcttcaTCCTCaattaa tcCCCCCTTTTGAATTAcccgagatatgtcatattttatcatatttacaagaaaaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1315848..1315862) /Source="Nicolas_upshift_promotors" /id="U1020" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.001998001998002" /xcortree=720 /SigmaFactorBS="ccgacataagaggacggaatcgtctgcttcaTCCTCaattaa tcCCCCCTTTTGAATTAcccgagatatgtcatattttatcatatttacaagaaaaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1315869..1317005 /gene="rapA" /locus_tag="BSU_12430" /old_locus_tag="BSU12430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11587784, 15805512, 15916600, 22267516, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11587784, 15805512, 15916600, 22267516, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_389125.1" /db_xref="EnsemblGenomes-Gn:BSU12430" /db_xref="EnsemblGenomes-Tr:CAB13100" /db_xref="GOA:Q00828" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG10652" /db_xref="UniProtKB/Swiss-Prot:Q00828" /translation="MRMKQTIPSSYVGLKINEWYTHIRQFHVAEAERVKLEVEREIED MEEDQDLLLYYSLMEFRHRVMLDYIKPFGEDTSQLEFSELLEDIEGNQYKLTGLLEYY FNFFRGMYEFKQKMFVSAMMYYKRAEKNLALVSDDIEKAEFAFKMAEIFYNLKQTYVS MSYAVQALETYQMYETYTVRRIQCEFVIAGNYDDMQYPERALPHLELALDLAKKEGNP RLISSALYNLGNCYEKMGELQKAAEYFGKSVSICKSEKFDNLPHSIYSLTQVLYKQKN DAEAQKKYREGLEIARQYSDELFVELFQFLHALYGKNIDTESVSHTFQFLEEHMLYPY IEELAHDAAQFYIENGQPEKALSFYEKMVHAQKQIQRGDCLYEI*" gene 1315869..1317005 /gene="rapA" /locus_tag="BSU_12430" /old_locus_tag="BSU12430" promotor_-35 complement(1315871..1315875) /Source="Nicolas_upshift_promotors" /id="U1020" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.001998001998002" /xcortree=720 /SigmaFactorBS="ccgacataagaggacggaatcgtctgcttcaTCCTCaattaa tcCCCCCTTTTGAATTAcccgagatatgtcatattttatcatatttacaagaaaaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1316995..1317129 /gene="phrA" /locus_tag="BSU_12440" /old_locus_tag="BSU12440" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1378051, 10629174, 11587784, 16816200, 17666034, 19380751, 20238180, 22267516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1378051, 10629174, 11587784, 16816200, 17666034, 19380751, 20238180, 22267516; Product type f: factor" /codon_start=1 /transl_table=11 /product="secreted inhibitor of the activity of phosphatase RapA (quorum sensing)" /protein_id="NP_389126.1" /db_xref="EnsemblGenomes-Gn:BSU12440" /db_xref="EnsemblGenomes-Tr:CAB13101" /db_xref="SubtiList:BG10653" /db_xref="UniProtKB/Swiss-Prot:Q00829" /translation="MKSKWMSGLLLVAVGFSFTQVMVHAGETANTEGKTFHIAARNQT *" gene 1316995..1317129 /gene="phrA" /locus_tag="BSU_12440" /old_locus_tag="BSU12440" downshifts 1317127 /Source="Nicolas_upshifts" /id="D689" /incds=0 /nref=257 /ntot=265 /MaxReadThrough="2.54197" /MaxDrop="9.28084" /score="10.6385823" /energy="-17" /TU="U1019" /idTUdmin="U1019" /TUdmin="-22" /isTUend="TRUE" CDS complement(1317157..1317414) /gene="yjpA" /locus_tag="BSU_12450" /old_locus_tag="BSU12450" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15779043; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389127.2" /db_xref="EnsemblGenomes-Gn:BSU12450" /db_xref="EnsemblGenomes-Tr:CAB13102" /db_xref="InterPro:IPR005545" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG13217" /db_xref="UniProtKB/Swiss-Prot:O34446" /translation="MYTYLMLTMRTEKFNQEHVAGHYEFLDRLQAEKRLKMFGPFSDA TGGAYVIEADSLEEAAEIGHADPLVASGSSELTIKEWKLKK*" gene complement(1317157..1317414) /gene="yjpA" /locus_tag="BSU_12450" /old_locus_tag="BSU12450" downshifts complement(1317178) /Source="Nicolas_upshifts" /id="D690" /incds=0 /nref=201 /ntot=255 /MaxReadThrough="0.7939" /MaxDrop="6.43836" /score="0.0520712077" /energy="-3.2" /TU="NA" /idTUdmin="U1021" /TUdmin=0 /isTUend="TRUE" misc_feature complement(1317428..1317447) /Source="Nicolas_upshift_promotors" /id="U1021" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3193 /SigmaFactorBS="ggtggcattcgtaggacgaaaagctcatatcatctatcaccg taatatggataaaTGTGTTAAACTGAAGTTCACggagggtctgaatatgtatacatat t" /listShort="yjpA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1317442) /Source="Nicolas_upshifts" /id="U1021" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3193 /SigmaFactorBS="ggtggcattcgtaggacgaaaagctcatatcatctatcaccg taatatggataaaTGTGTTAAACTGAAGTTCACggagggtctgaatatgtatacatat t" /listShort="yjpA" /GFF_Attribute="listLong" misc_feature 1317486..1317504 /Source="Nicolas_upshift_promotors" /id="U1022" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1524 /SigmaFactorBS="agtttaacacatttatccatattacggtgatagatgatatga gcttttcGTCCTACGAATGCCACCTAtttatgaaaaaagaaaaggagagatgataggt g" /listShort="xlyB" /listLong="yjqB, yjqC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1317497 /Source="Nicolas_upshifts" /id="U1022" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1524 /SigmaFactorBS="agtttaacacatttatccatattacggtgatagatgatatga gcttttcGTCCTACGAATGCCACCTAtttatgaaaaaagaaaaggagagatgataggt g" /listShort="xlyB" /listLong="yjqB, yjqC" CDS 1317535..1318488 /gene="xlyB" /locus_tag="BSU_12460" /old_locus_tag="BSU12460" /EC_number="3.5.1.28" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8760915, 9555893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760915, 9555893; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_389128.1" /db_xref="EnsemblGenomes-Gn:BSU12460" /db_xref="EnsemblGenomes-Tr:CAB13103" /db_xref="GOA:O34391" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR002502" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="InterPro:IPR036505" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG12699" /db_xref="UniProtKB/Swiss-Prot:O34391" /translation="MSIPVKKNLVSEAKYALKCPNAMSAEYITIHNTANDASAANEIS YMIGNTSSTSFHFAVDDQEVIQGLPLNRNAWHTGDGTNGPGNRKSIGVEICYSKSGGP KYEAAEALAISFVAQLLKERGWGIDRVRKHQDWSGKYCPHRILSEGRWDQVKAAIEKE LNGGVSAKKAAVSSSASEYHVKKGDTLSGIAASHGASVKTLQSINHITDPNHIKIGQV IKLPQTASASKSHAASSYPLPSGVIKVTSPLTQGTKVKQVQTALAALYFYPDKGAKNH GVDGVYGPKTANAVKRFQSVSGLTADGIYGPKTKAKMEEKL*" gene 1317535..1318488 /gene="xlyB" /locus_tag="BSU_12460" /old_locus_tag="BSU12460" promotor_no_box 1318383..1318483 /Source="Nicolas_upshift_promotors" /id="U1023" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.013986013986014" /xcortree=1484 /SigmaFactorBS="cccgaaaacagctaatgcagtgaaacgttttcagtctgtcag cggtttaacggctgatgggatttacggtccgaaaacgaaagcgaagatggaggaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1318443 /Source="Nicolas_upshifts" /id="U1023" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.013986013986014" /xcortree=1484 /SigmaFactorBS="cccgaaaacagctaatgcagtgaaacgttttcagtctgtcag cggtttaacggctgatgggatttacggtccgaaaacgaaagcgaagatggaggaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1318492 /Source="Nicolas_upshifts" /id="D691" /incds=0 /nref=8 /ntot=146 /MaxReadThrough="3.91295" /MaxDrop="4.29119" /score="10.6385823" /energy="-17" /TU="U1022" /idTUdmin="U1023" /TUdmin="-17" /isTUend="TRUE" downshifts complement(1318497) /Source="Nicolas_upshifts" /id="D692" /incds=0 /nref=2 /ntot=163 /MaxReadThrough="2.88318" /MaxDrop="3.60856" /score="14.6077768" /energy="-16" /TU="U1024" /idTUdmin="U1024" /TUdmin="-22" /isTUend="TRUE" CDS complement(1318528..1318905) /gene="yjqA" /locus_tag="BSU_12470" /old_locus_tag="BSU12470" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; conserved hypothetical protein" /protein_id="NP_389129.1" /db_xref="EnsemblGenomes-Gn:BSU12470" /db_xref="EnsemblGenomes-Tr:CAB13104" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG13218" /db_xref="UniProtKB/Swiss-Prot:O34593" /translation="MGFIDGLLGNASTLSTAAVQEELAHILLEGEKVEAAFKLVRDLI VFTDKRLILVDKQGITGKKTEFQSIPYKSISRFSVETAGRFDLDSELKIWISGAELPA VSKQFKKDESIYDIQKVLAAVCM*" gene complement(1318528..1318905) /gene="yjqA" /locus_tag="BSU_12470" /old_locus_tag="BSU12470" promotor_-10 complement(1318925..1318944) /Source="Nicolas_upshift_promotors" /id="U1024" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.304695304695305" /psig="0.993006993006993" /xcortree=2203 /SigmaFactorBS="cccctttaccagtcagcaccagtttactctactcatCTATGA AtgaaaacctttttTATAGTATGATTTGATAGAAtacgcagaggaggtatatgatggg g" /listShort="yjqA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1318940) /Source="Nicolas_upshifts" /id="U1024" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.304695304695305" /psig="0.993006993006993" /xcortree=2203 /SigmaFactorBS="cccctttaccagtcagcaccagtttactctactcatCTATGA AtgaaaacctttttTATAGTATGATTTGATAGAAtacgcagaggaggtatatgatggg g" /listShort="yjqA" /GFF_Attribute="listLong" promotor_-35 1318950..1318954 /Source="Nicolas_upshift_promotors" /id="U1025" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.522477522477522" /psig="0.993006993006993" /xcortree=2682 /SigmaFactorBS="tcctctgcgtattctatcaaatcatactataaaaaaGGTTTt cattcatagatgagTAGAGTAAACTGGTGCTGACtggtaaaggggggcgttcaagatg g" /listShort="yjqB, yjqC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1318958..1318964) /Source="Nicolas_upshift_promotors" /id="U1024" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.304695304695305" /psig="0.993006993006993" /xcortree=2203 /SigmaFactorBS="cccctttaccagtcagcaccagtttactctactcatCTATGA AtgaaaacctttttTATAGTATGATTTGATAGAAtacgcagaggaggtatatgatggg g" /listShort="yjqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1318970..1318989 /Source="Nicolas_upshift_promotors" /id="U1025" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.522477522477522" /psig="0.993006993006993" /xcortree=2682 /SigmaFactorBS="tcctctgcgtattctatcaaatcatactataaaaaaGGTTTt cattcatagatgagTAGAGTAAACTGGTGCTGACtggtaaaggggggcgttcaagatg g" /listShort="yjqB, yjqC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1318974 /Source="Nicolas_upshifts" /id="U1025" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.522477522477522" /psig="0.993006993006993" /xcortree=2682 /SigmaFactorBS="tcctctgcgtattctatcaaatcatactataaaaaaGGTTTt cattcatagatgagTAGAGTAAACTGGTGCTGACtggtaaaggggggcgttcaagatg g" /listShort="yjqB, yjqC" /GFF_Attribute="listLong" CDS 1319011..1319613 /gene="pghB" /locus_tag="BSU_12480" /old_locus_tag="BSU12480" /EC_number="3.4.19.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8760915, 15466572, 26158264; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; gamma-polyglutamate hydrolase" /protein_id="NP_389130.1" /db_xref="EnsemblGenomes-Gn:BSU12480" /db_xref="EnsemblGenomes-Tr:CAB13105" /db_xref="InterPro:IPR008585" /db_xref="SubtiList:BG13219" /db_xref="UniProtKB/Swiss-Prot:O34785" /translation="MEDMYDSFAALSASESEYRIIYEEKNGSELIVLGPHGGRIEPGV SELVRAFSDRCSIYLFEGLKQRNNRSLHLTSIRFDEPLALEKVNDHHYALAFHGYYDP KIPHTLVGGADRKKAKLICERLNEAGFSAELTNEKDRLAGVHPNNIVNRTKREMGLQL EVSTAQRNALFRNFGCRDKSYIQNDLFDRYVEAVKLGFYT*" gene 1319011..1319613 /gene="pghB" /locus_tag="BSU_12480" /old_locus_tag="BSU12480" promotor_-35 1319625..1319634 /Source="Nicolas_upshift_promotors" /id="U1026" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1363 /SigmaFactorBS="cttggcttttatacataaaactagacgggACCTGCACGGttg gcctattccTTCATACGCTGGGGTTGTGCgaaagtgtggggaggaatgattcatgttt t" /listShort="yjqC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1319640..1320569) /Source="Nicolas_S_feature" /locus_tag="new_1319640_1320569_c" /HighExp="M40t90, M40t45, H2O2, Cold, LBGstat, Etha, Sw, T0.30H, Heat, T1.0H" /AntisenseName="yjqC" /AntisenseCor="-0.110813865274572" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S454" promotor_-10 1319647..1319666 /Source="Nicolas_upshift_promotors" /id="U1026" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1363 /SigmaFactorBS="cttggcttttatacataaaactagacgggACCTGCACGGttg gcctattccTTCATACGCTGGGGTTGTGCgaaagtgtggggaggaatgattcatgttt t" /listShort="yjqC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1319656 /Source="Nicolas_upshifts" /id="U1026" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1363 /SigmaFactorBS="cttggcttttatacataaaactagacgggACCTGCACGGttg gcctattccTTCATACGCTGGGGTTGTGCgaaagtgtggggaggaatgattcatgttt t" /listShort="yjqC" /GFF_Attribute="listLong" CDS 1319690..1320526 /gene="xpdC" /locus_tag="BSU_12490" /old_locus_tag="BSU12490" /EC_number="1.11.1.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8760915, 15466572, 22752169, 27362423; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; manganese-containing peroxidase" /protein_id="NP_389131.2" /db_xref="EnsemblGenomes-Gn:BSU12490" /db_xref="EnsemblGenomes-Tr:CAB13106" /db_xref="GOA:O34423" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR027407" /db_xref="SubtiList:BG13220" /db_xref="UniProtKB/Swiss-Prot:O34423" /translation="MFYHIKELQYQAKPAHPDPVYAKKLQEVLGGQFGEISVMMQYLF QGFNCRADAKYKDLLYDVGTEEIGHVEMLATMISRLLDNAPADVQEDAYKSNPAIAAV MSGMNPQHAIVSGLGAMASDSEGYPWNAKYIISSGNLLADFRANLNAEAQGRLQVTRL YAMTDDPGVRDMLSFLIARDTYHQNMWYAAIKELEERERDIVVPTTFPRELEKQEVSY DLFNFSRGDESSQGRWAHGEAFDGRGEFRYIPAPIAFASAPHLKPAPMWLHNTVPPMS KC*" gene 1319690..1320526 /gene="xpdC" /locus_tag="BSU_12490" /old_locus_tag="BSU12490" downshifts 1320514 /Source="Nicolas_upshifts" /id="D693" /incds=0 /nref=4 /ntot=53 /MaxReadThrough="2.02835" /MaxDrop="3.83938" /score="0.0878183333" /energy="-20.1" /TU="NA" /idTUdmin="U1026" /TUdmin=0 /isTUend="TRUE" CDS complement(1320570..1321166) /gene="xkdA" /locus_tag="BSU_12500" /old_locus_tag="BSU12500" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8760915, 16267290, 22933559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760915, 16267290, 22933559; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; putative peptidase" /protein_id="NP_389132.3" /db_xref="EnsemblGenomes-Gn:BSU12500" /db_xref="EnsemblGenomes-Tr:CAB13107" /db_xref="InterPro:IPR010359" /db_xref="SubtiList:BG10993" /db_xref="UniProtKB/Swiss-Prot:P39780" /translation="MGDYLSHLEEYVKNLYGRLGITSPHHIDMLKIAKDLDIWVHFED MGSMMVKYDGMYSIVLNQKKSREEQWEDFGHELCHVLKHAGNHFQMNKLFRELQEFQA NQFMYHFCVPTFMLLQMELPQWRSQALATIAAVFRVTKEFADKRLDMFERRKAGIQFQ KRLAYLLSHKRPNAYEEGDQQHLQVAEEKALYHIGKNI*" gene complement(1320570..1321166) /gene="xkdA" /locus_tag="BSU_12500" /old_locus_tag="BSU12500" S_feature complement(1321205..1321328) /Source="Nicolas_S_feature" /locus_tag="new_1321205_1321328_c" /HighExp="HiTm, MG 10, MG 5, MG-0.1, MG 25, GM 120, MG 45, GM 15, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S455" downshifts complement(1321248) /Source="Nicolas_upshifts" /id="D694" /incds=0 /nref=10 /ntot=151 /MaxReadThrough="4.55391" /MaxDrop="3.62157" /score="-8.64059763" /energy="-7.9" /TU="U1027" /idTUdmin="U1027" /TUdmin="-1582" /isTUend="FALSE" CDS complement(1321329..1321670) /gene="xre" /locus_tag="BSU_12510" /old_locus_tag="BSU12510" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8083175, 20889742" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8083175, 20889742; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX transcriptional regulator" /protein_id="NP_389133.1" /db_xref="EnsemblGenomes-Gn:BSU12510" /db_xref="EnsemblGenomes-Tr:CAB13108" /db_xref="GOA:P23789" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG10994" /db_xref="UniProtKB/Swiss-Prot:P23789" /translation="MIGGRLKSLRGKRTQEEIASHIGVSRARYSHYENGRSEPDYDTL QKLADYFQVTTDYLLTGKDKKSDDDMFSDPDLQLAYRDMQDFSPESKQQAIEFINYLK EKEKNRKPKNK*" gene complement(1321329..1321670) /gene="xre" /locus_tag="BSU_12510" /old_locus_tag="BSU12510" promotor_-10 complement(1321702..1321721) /Source="Nicolas_upshift_promotors" /id="U1027" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.448551448551449" /psig="0.999000999001" /xcortree=3029 /SigmaFactorBS="tcaagttatttttgatactttttttatcataaCTTTATTttg atacattttGTATCTATAATCATAAGTAAcgtagggagtttaaaaaagagaggtcata g" /listShort="xre, S455, xkdA, S454" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1321712) /Source="Nicolas_upshifts" /id="U1027" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.448551448551449" /psig="0.999000999001" /xcortree=3029 /SigmaFactorBS="tcaagttatttttgatactttttttatcataaCTTTATTttg atacattttGTATCTATAATCATAAGTAAcgtagggagtttaaaaaagagaggtcata g" /listShort="xre, S455, xkdA, S454" /GFF_Attribute="listLong" promotor_-35 complement(1321734..1321740) /Source="Nicolas_upshift_promotors" /id="U1027" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.448551448551449" /psig="0.999000999001" /xcortree=3029 /SigmaFactorBS="tcaagttatttttgatactttttttatcataaCTTTATTttg atacattttGTATCTATAATCATAAGTAAcgtagggagtttaaaaaagagaggtcata g" /listShort="xre, S455, xkdA, S454" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1321768..1321771 /Source="Nicolas_upshift_promotors" /id="U1028" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1519 /SigmaFactorBS="tcaaaataaagttatgataaaaaaagtatcaaaaataaCTTG atgatacagaatgtATCGTTTATACTTGGTAACAtccgatacaaaatgtatcaaaaaa g" /listShort="yjzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1321786..1321805 /Source="Nicolas_upshift_promotors" /id="U1028" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1519 /SigmaFactorBS="tcaaaataaagttatgataaaaaaagtatcaaaaataaCTTG atgatacagaatgtATCGTTTATACTTGGTAACAtccgatacaaaatgtatcaaaaaa g" /listShort="yjzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1321790 /Source="Nicolas_upshifts" /id="U1028" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1519 /SigmaFactorBS="tcaaaataaagttatgataaaaaaagtatcaaaaataaCTTG atgatacagaatgtATCGTTTATACTTGGTAACAtccgatacaaaatgtatcaaaaaa g" /listShort="yjzJ" /GFF_Attribute="listLong" CDS 1321848..1322027 /gene="yjzJ" /locus_tag="BSU_12519" /old_locus_tag="BSU12519" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; conserved hypothetical protein" /protein_id="YP_003097711.1" /db_xref="EnsemblGenomes-Gn:BSU12519" /db_xref="EnsemblGenomes-Tr:CAX52601" /db_xref="UniProtKB/Swiss-Prot:C0H3Z4" /translation="MYPIQIVFSENPIDQRHLGQSGGTISFTACGLPVFHFETQEQFQ AYMMLKGEAAYNEKR*" gene 1321848..1322027 /gene="yjzJ" /locus_tag="BSU_12519" /old_locus_tag="BSU12519" CDS 1322014..1322850 /gene="xkdB" /locus_tag="BSU_12520" /old_locus_tag="BSU12520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="phage PBSX; conserved hypothetical protein" /protein_id="NP_389134.2" /db_xref="EnsemblGenomes-Gn:BSU12520" /db_xref="EnsemblGenomes-Tr:CAB13109" /db_xref="GOA:P39781" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10995" /db_xref="UniProtKB/Swiss-Prot:P39781" /translation="MKNDKSYPFPTYSGLLNSEHYDKIGPALWLFLWFISSTTKEIEK DGVSWGIVLGHKPLKAREMAAVFGVSEKTVRRWLELLENHDYIKAVRAPYGLMISVKH SKKFSFRSDNTVHGSLKERPFSPQTPDTNDRTDIDKTNKYTAADDAVDHIAKRFTQLR SAQEGRTVYPSSRDYQAIARIVAIGVPVTQTIKWLEECFQAFENRRTAASETIKAFRY CSKFIEDRFFAQQAKKNAAIQHERMKKHDKTNNRTDFGRAEKRETSITGGQTGRIRRK QV*" gene 1322014..1322850 /gene="xkdB" /locus_tag="BSU_12520" /old_locus_tag="BSU12520" CDS 1322750..1323550 /gene="xkdC" /locus_tag="BSU_12530" /old_locus_tag="BSU12530" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; putative DNA binding protein" /protein_id="NP_389135.2" /db_xref="EnsemblGenomes-Gn:BSU12530" /db_xref="EnsemblGenomes-Tr:CAB13110" /db_xref="GOA:P39782" /db_xref="InterPro:IPR002611" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10996" /db_xref="UniProtKB/Swiss-Prot:P39782" /translation="MTKRTIEQILDELRRGRRPLLADKPAESDASRYDCLRCKDQGGY LVRQNGLEVWTMCSCMAERKVKRLLGASEITHAFRQLGFKEFRTEGKPQAIKDAFECT KEYVADYEQIKDCRKNSIALLGQPGSGKTHLLTAAANELMRTCYVPVIYFPFVEGFTD LKNDFALLEAKLNRMKQADVLFIDDLFKPVNGKPRATDWQLEQMYSVLNYRYLNHKPI LLSSELTIEGLVRVDEALGTRIYEMCSDYLVIIKGAAYELNHRLEGVR*" gene 1322750..1323550 /gene="xkdC" /locus_tag="BSU_12530" /old_locus_tag="BSU12530" CDS 1323550..1323717 /gene="ykzK" /locus_tag="BSU_12539" /old_locus_tag="BSU12539" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; conserved hypothetical protein" /protein_id="YP_003097712.1" /db_xref="EnsemblGenomes-Gn:BSU12539" /db_xref="EnsemblGenomes-Tr:CAX52602" /db_xref="UniProtKB/Swiss-Prot:C0H3Z5" /translation="MCKLCQTKKVIVEHTGIGVVFHPCPNCRSGTDLTPVIQKLEQML TAGKARLNIYD*" gene 1323550..1323717 /gene="ykzK" /locus_tag="BSU_12539" /old_locus_tag="BSU12539" CDS 1323802..1324152 /gene="xkdD" /locus_tag="BSU_12540" /old_locus_tag="BSU12540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; conserved hypothetical protein" /protein_id="NP_389136.1" /db_xref="EnsemblGenomes-Gn:BSU12540" /db_xref="EnsemblGenomes-Tr:CAB13111" /db_xref="SubtiList:BG10997" /db_xref="UniProtKB/Swiss-Prot:P39783" /translation="MKVLAKTKQAEKSPAPWRAVPCGDTKPIYIYSAYSEEEKERFPY SNGRLIAAVFDLSSYSQKSNASLMAAAPELLEASKAALDFLKGNSIHSKERIIQLLEK AEASAAPKRGGNKT*" gene 1323802..1324152 /gene="xkdD" /locus_tag="BSU_12540" /old_locus_tag="BSU12540" CDS 1324149..1324355 /gene="xtrA" /locus_tag="BSU_12550" /old_locus_tag="BSU12550" /experiment="publication(s) with functional evidences, PMID:8760915" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760915; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; conserved protein of unknown function" /protein_id="NP_389137.1" /db_xref="EnsemblGenomes-Gn:BSU12550" /db_xref="EnsemblGenomes-Tr:CAB13112" /db_xref="InterPro:IPR035530" /db_xref="SubtiList:BG11559" /db_xref="UniProtKB/Swiss-Prot:P54344" /translation="MIHPKKLLHIDSVTLKSQLEDGKIRVIIVDGIKQEAWITEAPEH GKTLVETRKGDLARVEFEIGYKLN*" gene 1324149..1324355 /gene="xtrA" /locus_tag="BSU_12550" /old_locus_tag="BSU12550" CDS 1324471..1324980 /gene="xpf" /locus_tag="BSU_12560" /old_locus_tag="BSU12560" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8083174, 25176138; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; putative RNA polymerase PBSX sigma factor-like" /protein_id="NP_389138.1" /db_xref="EnsemblGenomes-Gn:BSU12560" /db_xref="EnsemblGenomes-Tr:CAB13113" /db_xref="GOA:P39784" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10998" /db_xref="UniProtKB/Swiss-Prot:P39784" /translation="MQDLLFEYKRTLKQTRIQYKPLAEADESVLSAEELKDKKIIRNM ITDLEYVTEWLEKGRQPGIRRAIDRRDVYQRLMIKDPRIIESFSSAMMFEPDGQVSEE DRDRIREALALLTDREKEMFLLHKVECFSYERIADLLGVKKSTVQTTIKRASLKMQRQ QEEMNRSLA*" gene 1324471..1324980 /gene="xpf" /locus_tag="BSU_12560" /old_locus_tag="BSU12560" misc_feature 1324987..1325005 /Source="Nicolas_upshift_promotors" /id="U1029" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1522 /SigmaFactorBS="agacagcaggaagaaatgaatcgatcacttgcctgaaagctt GTCATACGTTTGCCACCTAtaagtgaatagagcatgacactaagcggctggctgatca g" /listShort="S456, xtmA, xtmB, xkdE, xkdF, xkdG, ykzL, xkdH, xkdI, xkdJ, ykzM, xkdK, xkdM, S457, xkdN, xkzB, xkdO, xkdP, xkdQ, xkdR, xkdS, xkdT, xkdU, xkzA, xkdV, xkdW, xkdX, xepA, xhlA, xhlB, xlyA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1325005..1325095 /Source="Nicolas_S_feature" /locus_tag="new_1325005_1325095" /HighExp="HPh, M40t90, LPh, MG 120, MG 150, MG 90, LBGexp, MG 60, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.467804" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S456" upshifts 1325005 /Source="Nicolas_upshifts" /id="U1029" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1522 /SigmaFactorBS="agacagcaggaagaaatgaatcgatcacttgcctgaaagctt GTCATACGTTTGCCACCTAtaagtgaatagagcatgacactaagcggctggctgatca g" /listShort="S456, xtmA, xtmB, xkdE, xkdF, xkdG, ykzL, xkdH, xkdI, xkdJ, ykzM, xkdK, xkdM, S457, xkdN, xkzB, xkdO, xkdP, xkdQ, xkdR, xkdS, xkdT, xkdU, xkzA, xkdV, xkdW, xkdX, xepA, xhlA, xhlB, xlyA" /GFF_Attribute="listLong" CDS 1325096..1325893 /gene="xtmA" /locus_tag="BSU_12570" /old_locus_tag="BSU12570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8083174; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; prophage terminase (small subunit)" /protein_id="NP_389139.1" /db_xref="EnsemblGenomes-Gn:BSU12570" /db_xref="EnsemblGenomes-Tr:CAB13114" /db_xref="GOA:P39785" /db_xref="InterPro:IPR005335" /db_xref="InterPro:IPR018925" /db_xref="SubtiList:BG10999" /db_xref="UniProtKB/Swiss-Prot:P39785" /translation="MKTQQREQALAIYQQHQGKITNRAIADTIGVSAKTIGIWKKQDK WKEALFSASKNEQKQRPINNDELNERQRLFCLYYVKSFNATQSAIKAGYSPDSAHVTG SRLLKNEKVAAEIRRIKKEMVNEMFIEAMDVLQVYIKIAFADITDYVTFGKKEVQAVG KSGPLFDEDDNPIMKEISFVDVKDSGLVDGTIVTEAKLGKEGIAIKLADKMKALEKLS LYFDLFPDQFKQKIENEKLKLAKQKAEKTDDSQEPIEIMIKRKERKS*" gene 1325096..1325893 /gene="xtmA" /locus_tag="BSU_12570" /old_locus_tag="BSU12570" CDS 1325890..1327191 /gene="xtmB" /locus_tag="BSU_12580" /old_locus_tag="BSU12580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17945256, 19347993; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; prophage terminase (large subunit)" /protein_id="NP_389140.1" /db_xref="EnsemblGenomes-Gn:BSU12580" /db_xref="EnsemblGenomes-Tr:CAB13115" /db_xref="GOA:P39786" /db_xref="InterPro:IPR006437" /db_xref="InterPro:IPR035412" /db_xref="InterPro:IPR035413" /db_xref="SubtiList:BG11000" /db_xref="UniProtKB/Swiss-Prot:P39786" /translation="MIVKEINPHFEDYVFNWEQTYQFLVGGYGSSKSYHTALKIVLKL LKEKRTALVIREVFDTHRDSTFALFQEVIEELGLTKAVASLSSPLQLRFHNGSRIMFK GMDNPAKLKSVHNISLIWIEECSEVKYEGFKELIGRLRHPELKLHMICTTNPVGTSNW TYRHFFRDERKKRFVLDDSELYEKRTIVKGDTYYHHSTANDNLFLPESYVKQLDGLKE YDPDLYRIARKGRFGVNGIRVLPQFEVLPHDQVKKCIAAISKPIFRTGMDFGFEESYN AVVRLAVDPEKKYLYIYWEYYQNKMTDDRTAEELREFIETQELIKADSAEPKSIQYFR QQGFRMVGARKFPGSRLQYTKKVKRFKKIFCSDRCENVIYELETLTYAKDKNGALIED EFTIDPHTLSAIWYALDDYEVADMKETAHKRMRPNRERRRS*" gene 1325890..1327191 /gene="xtmB" /locus_tag="BSU_12580" /old_locus_tag="BSU12580" CDS 1327195..1328682 /gene="xkdE" /locus_tag="BSU_12590" /old_locus_tag="BSU12590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23027764, 23419885; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; phage capsid portal protein" /protein_id="NP_389141.2" /db_xref="EnsemblGenomes-Gn:BSU12590" /db_xref="EnsemblGenomes-Tr:CAB13116" /db_xref="InterPro:IPR006430" /db_xref="InterPro:IPR006944" /db_xref="InterPro:IPR016753" /db_xref="SubtiList:BG11540" /db_xref="UniProtKB/Swiss-Prot:P54325" /translation="MHNQTVRATVFKANAAAPQTKQIYEDDFSELYGEDIIAPPYNII ELKTIAEYSTILQQCIDAYRVNITGFGFDVEYTFDVNASDVDQAKKKRAEKDWARLEA FYKCLHFDESAEMILGYAIEDREKTGNGFMEVLRDGAGKPAGIEYLDVKYMRVCGAGE PVEVSFVYEENGKMKRIKRQKRFRKYVQMINGKKVFFKEYGDPRKMDIRTGEYVNTLA EKYQANEAIHLKIGSGVYGVPRWIGNIVNLYGARKAEELNFMYFKQGRHVPAAITVEN GMLSEASYRELQEYMNDLEGVENAHKFLLIEAEGIAKEKDLHGGEDITPVSVEIKSLA EILQNDALFLEYDEKSRNKLRSAFRLPPLYTGEAQEYNRATADTARKITEEQVFQPER KTLVNKLNTLLLPELNIHDVRLTLKGPDFRDPLEIAKVLGPFITAGAVSPNDLRDLAG RVLGKTLEEWPEDIYKRPAGQDAEKTNLAALMQELKESIEDIKTS*" gene 1327195..1328682 /gene="xkdE" /locus_tag="BSU_12590" /old_locus_tag="BSU12590" promotor_-35 1328204..1328213 /Source="Nicolas_upshift_promotors" /id="U1030" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1235 /SigmaFactorBS="gaaatcaaatctttggctgaaattcTCCAAAACGAcgccttg tttctTGAATACGATGAAAAAAGCAgaaataagctgcgttccgcgttccgtctccccc c" /listShort="xkdF, xkdG, ykzL, xkdH, xkdI, xkdJ, ykzM, xkdK, xkdM, S457, xkdN, xkzB, xkdO, xkdP, xkdQ, xkdR, xkdS, xkdT, xkdU, xkzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1328226..1328245 /Source="Nicolas_upshift_promotors" /id="U1030" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1235 /SigmaFactorBS="gaaatcaaatctttggctgaaattcTCCAAAACGAcgccttg tttctTGAATACGATGAAAAAAGCAgaaataagctgcgttccgcgttccgtctccccc c" /listShort="xkdF, xkdG, ykzL, xkdH, xkdI, xkdJ, ykzM, xkdK, xkdM, S457, xkdN, xkzB, xkdO, xkdP, xkdQ, xkdR, xkdS, xkdT, xkdU, xkzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1328239 /Source="Nicolas_upshifts" /id="U1030" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1235 /SigmaFactorBS="gaaatcaaatctttggctgaaattcTCCAAAACGAcgccttg tttctTGAATACGATGAAAAAAGCAgaaataagctgcgttccgcgttccgtctccccc c" /listShort="xkdF, xkdG, ykzL, xkdH, xkdI, xkdJ, ykzM, xkdK, xkdM, S457, xkdN, xkzB, xkdO, xkdP, xkdQ, xkdR, xkdS, xkdT, xkdU, xkzA" /GFF_Attribute="listLong" CDS 1328702..1329529 /gene="xkdF" /locus_tag="BSU_12600" /old_locus_tag="BSU12600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; conserved hypothetical protein" /protein_id="NP_389142.2" /db_xref="EnsemblGenomes-Gn:BSU12600" /db_xref="EnsemblGenomes-Tr:CAB13117" /db_xref="InterPro:IPR027924" /db_xref="SubtiList:BG11541" /db_xref="UniProtKB/Swiss-Prot:P54326" /translation="MARELRNAKISFVSYVDKAANQTEFFFTKSAEPPSFEKKVRLFT KSEQDEQKLVYGIVYEPDVPDAHGDFMTAEEIEKAAHGFLAEAREIDINHSFEGGTGV VVESYVAPDDFMIGSKRITKGSWVLVTRASDEVWEQIKAGIITGYSMAGTADVYEEEP VEKAGFFSVFKQMLADKTGKETEEMRKEDMKESFEHALYPLLKRLERIEKNTDTEEKP EQTGDDERLKKLVEDMLAPLIERIEALEKARGASKQTADDTGGNTEQVKKSIWSGLL* " gene 1328702..1329529 /gene="xkdF" /locus_tag="BSU_12600" /old_locus_tag="BSU12600" CDS 1329555..1330490 /gene="xkdG" /locus_tag="BSU_12610" /old_locus_tag="BSU12610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897825; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; putative phage chromosome binding protein" /protein_id="NP_389143.1" /db_xref="EnsemblGenomes-Gn:BSU12610" /db_xref="EnsemblGenomes-Tr:CAB13118" /db_xref="GOA:P54327" /db_xref="InterPro:IPR024455" /db_xref="SubtiList:BG11542" /db_xref="UniProtKB/Swiss-Prot:P54327" /translation="MRNQEIIRKAEMSLSALKSGGLMNPAQASAFIRMVQNTPTIFSE SRVIQMENDSQKFEKIGFGQRILRAAQEGKALSNDELTVPTTSTVQLNTKEVIAEINI TYDTLENNIEKDGLQQTIMQILAERAAVDIEELIVNGDTASADPYLAQLDGIRKQAVS HIVDMNGEELSRATFKKGLKAVPPKYLRIPQEFRFYTSHGLEVEWKDRVADRQTNLGD QAVQGGLSTAFGVPVKGVSNIQPYTVGEGDAQYDASDIILTHPKNIILGFSRNIRIEV DKDIRSRKFIIVLTAKLDSKFEEEDACAKLINVKE*" gene 1329555..1330490 /gene="xkdG" /locus_tag="BSU_12610" /old_locus_tag="BSU12610" CDS 1330512..1330895 /gene="ykzL" /locus_tag="BSU_12619" /old_locus_tag="BSU12619" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; conserved hypothetical protein" /protein_id="YP_003097713.1" /db_xref="EnsemblGenomes-Gn:BSU12619" /db_xref="EnsemblGenomes-Tr:CAX52603" /db_xref="InterPro:IPR013514" /db_xref="InterPro:IPR036558" /db_xref="UniProtKB/Swiss-Prot:C0H3Z6" /translation="MLIEPTDVASYSVYDRVKNRPEELLAQDIIEAEAEAALITGHRF EDSLYDPLPGKVKLALVKLAQYFALVNSDESASSSYQYEKMGDYSYTVSGEGRIQRPE VYHLLEEFIKPGYVPESSRLKVRSL*" gene 1330512..1330895 /gene="ykzL" /locus_tag="BSU_12619" /old_locus_tag="BSU12619" CDS 1330892..1331248 /gene="xkdH" /locus_tag="BSU_12620" /old_locus_tag="BSU12620" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; conserved hypothetical protein" /protein_id="NP_389144.1" /db_xref="EnsemblGenomes-Gn:BSU12620" /db_xref="EnsemblGenomes-Tr:CAB13119" /db_xref="InterPro:IPR024556" /db_xref="PDB:3F3B" /db_xref="SubtiList:BG11543" /db_xref="UniProtKB/Swiss-Prot:P54328" /translation="MSYRQMLIHRCDIYHEAAQAPSAGRFGIPADRLQPVISYPDTPD EQDVPCYFTEKTQQLIQEEPDQTVYHSFLVHFPLSADIRVNDKIIWENHKYILKLPKR IRHHHWEVVAVRDESL*" gene 1330892..1331248 /gene="xkdH" /locus_tag="BSU_12620" /old_locus_tag="BSU12620" CDS 1331245..1331730 /gene="xkdI" /locus_tag="BSU_12630" /old_locus_tag="BSU12630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; conserved hypothetical protein" /protein_id="NP_389145.1" /db_xref="EnsemblGenomes-Gn:BSU12630" /db_xref="EnsemblGenomes-Tr:CAB13120" /db_xref="InterPro:IPR010064" /db_xref="SubtiList:BG11544" /db_xref="UniProtKB/Swiss-Prot:P54329" /translation="MKIAGLKQLNTALKEAASGGFSRQASRWLEECGQDFLEIVQSEL ISTQTIDTEKLLSSFEKGAEDNLWIVQSGGLSLEVGTQLDYASFLNDGHWTSKQDVRW VPGRFQGSRFIYDPAASTGMALKRKWIPGTGYWDHALLLYEQLFEKSLESKLRQWLKK L*" gene 1331245..1331730 /gene="xkdI" /locus_tag="BSU_12630" /old_locus_tag="BSU12630" CDS 1331743..1332183 /gene="xkdJ" /locus_tag="BSU_12640" /old_locus_tag="BSU12640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; conserved hypothetical protein" /protein_id="NP_389146.1" /db_xref="EnsemblGenomes-Gn:BSU12640" /db_xref="EnsemblGenomes-Tr:CAB13121" /db_xref="SubtiList:BG11545" /db_xref="UniProtKB/Swiss-Prot:P54330" /translation="MNSETGSIMAFLYSRWSVPIYERELPDHFQVPSLYVPPPSVFEE TDTVSTFKKTYSLNVKLFHLDSVQALDEADRLADAIREARNMIPLLSESGEKTGDMVR ISQIETRVGDRGEAAMVIRWSSRYYYHKTEQPVLQDIDMNSGVK*" gene 1331743..1332183 /gene="xkdJ" /locus_tag="BSU_12640" /old_locus_tag="BSU12640" CDS 1332187..1332405 /gene="ykzM" /locus_tag="BSU_12649" /old_locus_tag="BSU12649" /function="17.2: Prophage functions" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; conserved hypothetical protein" /protein_id="YP_003097714.1" /db_xref="EnsemblGenomes-Gn:BSU12649" /db_xref="EnsemblGenomes-Tr:CAX52604" /db_xref="UniProtKB/Swiss-Prot:C0H3Z7" /translation="MSKDKQQKKAVHTKSREALFDTADLIKHAKELFGVKPDILQGAL FGVDQPRMTKSEANQLIQTFLTKEVMSS*" gene 1332187..1332405 /gene="ykzM" /locus_tag="BSU_12649" /old_locus_tag="BSU12649" CDS 1332402..1333802 /gene="xkdK" /locus_tag="BSU_12650" /old_locus_tag="BSU12650" /function="17.2: Prophage functions" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; conserved hypothetical protein" /protein_id="NP_389147.2" /db_xref="EnsemblGenomes-Gn:BSU12650" /db_xref="EnsemblGenomes-Tr:CAB13122" /db_xref="InterPro:IPR020287" /db_xref="InterPro:IPR035089" /db_xref="InterPro:IPR035326" /db_xref="SubtiList:BG11546" /db_xref="UniProtKB/Swiss-Prot:P54331" /translation="MNGGTFTTGKEKERAGIYFNFKTTAQERVSLSERGTVALPVASS WGEAKTFVSISSVEDLNKKVGLSIDDPSLLLLREAKKNAKTVLMYRLTEGVRASADIA EGVKATAVYGGTKGNDIIIRINQNVLDANSFDVTTYMDESEVDKQTVKKAEELTANGY VTFTGTGDLSSTIPLTGSEGDTAAETLNASAGIRLSGGTDKAPVNSDYTDFLAAAETE SFDVIALPVAEGDQLKATFAAFIKRLRDGQGQKVQGVTANYAGDYEGIINVTEGVLLE DGTEVTPDKATAWVAGASAGATFNQSLTFVEYEGAVDVLHRLDHDTIVERLGKGEFLF TFDARDKSVSVEKDINSLVTFTAEKNKKFAKNKIVRVLDAVNNDLTRELKALIKSRKG SGSDIPASEDGLQYVKTMITQYMTTLQDAGGITGFDSDEDITISMNEDRDGFLIDLAV QPVDAAEKFYFNVEVN*" gene 1332402..1333802 /gene="xkdK" /locus_tag="BSU_12650" /old_locus_tag="BSU12650" CDS 1333804..1334247 /gene="xkdM" /locus_tag="BSU_12660" /old_locus_tag="BSU12660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="phage PBSX; conserved hypothetical protein" /protein_id="NP_389148.1" /db_xref="EnsemblGenomes-Gn:BSU12660" /db_xref="EnsemblGenomes-Tr:CAB13123" /db_xref="InterPro:IPR018989" /db_xref="PDB:2GUJ" /db_xref="PDB:5LI2" /db_xref="SubtiList:BG11547" /db_xref="UniProtKB/Swiss-Prot:P54332" /translation="MALKAQNTISGKEGRLFLDGEEMAHIKTFEANVEKNKSEVNIMG RRMTGHKTTGANGTGTATFYKVTSKFVLLMMDYVKKGSDPYFTLQAVLDDQSSGRGTE RVTLYDVNFDSAKIASLDVDSEALEEEVPFTFEDFDVPEKLSDTF*" gene 1333804..1334247 /gene="xkdM" /locus_tag="BSU_12660" /old_locus_tag="BSU12660" S_feature 1334248..1334338 /Source="Nicolas_S_feature" /locus_tag="new_1334248_1334338" /HighExp="M40t90, HPh, LPh, MG 120, MG 150, MG 90, MG 60, Gly, dia0, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, Sig-" /TUshortPSig="0.999, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S457" CDS 1334339..1334785 /gene="xkdN" /locus_tag="BSU_12671" /old_locus_tag="BSU12671" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; conserved hypothetical protein" /protein_id="NP_389149.2" /db_xref="EnsemblGenomes-Gn:BSU12671" /db_xref="EnsemblGenomes-Tr:CAB13124" /db_xref="InterPro:IPR014986" /db_xref="SubtiList:BG11548" /db_xref="UniProtKB/Swiss-Prot:P54333" /translation="MSEKNENVYDLSFFMPGKTIEAEEIKVPISKRFVDKKGNVIPFI LKPITTERIDELEKENTTFKNVKGRGRVKDLDSQRFYARIAIESTIYPDFRSKDLREA YKTADPVEVAKRVLSVGGEYANWLNKAIEINGFEDDLEDLEEEAKN*" gene 1334339..1334785 /gene="xkdN" /locus_tag="BSU_12671" /old_locus_tag="BSU12671" CDS 1334815..1334964 /gene="xkzB" /locus_tag="BSU_12672" /old_locus_tag="BSU12672" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; conserved hypothetical protein" /protein_id="YP_003097715.1" /db_xref="EnsemblGenomes-Gn:BSU12672" /db_xref="EnsemblGenomes-Tr:CAX52605" /db_xref="UniProtKB/Swiss-Prot:C0H3Z8" /translation="MYYAMHELHYSPSQLLELYEAPKHFKALLFGLIGYKLDLLEKES RRGGN*" gene 1334815..1334964 /gene="xkzB" /locus_tag="BSU_12672" /old_locus_tag="BSU12672" CDS 1334966..1338964 /gene="xkdO" /locus_tag="BSU_12680" /old_locus_tag="BSU12680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20665904; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; putative tape measure protein" /protein_id="NP_389150.2" /db_xref="EnsemblGenomes-Gn:BSU12680" /db_xref="EnsemblGenomes-Tr:CAB13125" /db_xref="InterPro:IPR008258" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG11549" /db_xref="UniProtKB/Swiss-Prot:P54334" /translation="MAKLTARFDLEDKVSKKLKRIHKGFQEVEKKVKTINRQIKISIR AEDQAFYRLRKINDYIILKFAKSLEIKVVLDDQVTSKLDAIERKLKRLPKETKLTVSL VDRTAAAYKKIKKMLSNQKLSFLLIPDDKVTSTVKRIIGYIKKNLKNGYTVKLKVIDE ITKTVNRLTALLRKFEKTYYVKVVVKTKISDKINKKESLINKETSKKESDKSSDKGSD KNSDQKPGWVGKIKGWLKDWWTKSAWPWIKDTLNEIGKAFLDRFKERLIEKLKNDVFD KIIDKILGPQKKDDSGENSDTDKKVLNRNTGGNCCCDCCEGGISPGTKNKKTYRKKKS PTKAPNRTLKVPGEVIRRRQSGTPAESAPRTSGSKLKNWLGGLKSLGKDSSKLGKAFR GMGKAVPYVGSALAVFDLAGINKDNAGEKVGSIGGRIAGAEAGATAGAEAGATIGSFV GPEGTAIGGAIGGIGGGLVGGIGGEEAGKNIGKMFDTSKLKESISNSLFNKEWWSGKW NSISDTANGAITWIEDTWSKVSTWFDQYVFTPIYNVAVPVINFIVGLFAYAWDGILAV WNIVYPWFKDNVWDPISGAVTNVATTIWTGLCNAWTVISGIWSTVSTWFMDNVWNPVS EAVTTAATWIWSKINDAWTIISNIWTGVSNWFYDNVWNPIVKKVEDIKTSIKEKFDDA RKFFEDAWDGIETWFNEHVKDPLVKVSEKIAEKFQWLFDLKDSVGGFVAKVIHRGEEV THLKKKPIKKDSKEKKTSSKPTTNNIFAQSPSNNNMTVFQQALDQNATGGYITKPTIS WIGEAGKEFVIPVDNNRGRGKMLLSQAASKLGMQVVDDMGAASSSGGSPASVSGGAAV SPLSGTASPVMNTANLTGQASTLGQQFSEGFGKGISDQPVKMEDWKKKNINTPFTQMI SASPNYGKQMVSGYAKGQSGTATGTDGFLQSKVKTPFQATVSKSSSWGTGTVKGFAQG QNSTQTGTAQYVSTHVDKPFLRSKDTSNSWGSGLIGNFVTGMNSKSSEVKQAAKDMAK RVEQAFREELDIHSPSRVMMSLGRFASVGVVKGLDSVDVKKYAEKQAGSLAAAYSGMG AVGGNVKQWLMAAIMATKTPLSWLSGLMTIAQYESGGNPNSINLWDSNAKAGNPSQGL MQTVPTTFNAHKAPGMGNIRNPIHNAAAAIGYIKSRYGSIDNVPGIKSLKRGGPYVGY ANGGLITKEQIARVGEGNKREWIIPEERGIRGRYLLQRAAQALGMEVTDPSQSQQSEL SSGQVSAVTSASRPTAAVSGSKEIYIQFNGDQHFHNGQDAESLAAKIKQALIDELQKD INIGTKGVVAFD*" gene 1334966..1338964 /gene="xkdO" /locus_tag="BSU_12680" /old_locus_tag="BSU12680" promotor_-10 complement(1335370..1335388) /Source="Nicolas_upshift_promotors" /id="U1031" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=2788 /SigmaFactorBS="gatgacctttagttttactgtgtatccgttTTTCAAATtttt cttaatataACCGATAATCCTTTTAACTgtagaagtaaccttgtcatctggaatcaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1335379) /Source="Nicolas_upshifts" /id="U1031" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=2788 /SigmaFactorBS="gatgacctttagttttactgtgtatccgttTTTCAAATtttt cttaatataACCGATAATCCTTTTAACTgtagaagtaaccttgtcatctggaatcaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1335402..1335409) /Source="Nicolas_upshift_promotors" /id="U1031" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=2788 /SigmaFactorBS="gatgacctttagttttactgtgtatccgttTTTCAAATtttt cttaatataACCGATAATCCTTTTAACTgtagaagtaaccttgtcatctggaatcaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1336396 /Source="Nicolas_upshifts" /id="D695" /incds=1 /nref=1 /ntot=43 /MaxReadThrough="6.12795" /MaxDrop="2.89794" /score="11.201424" /energy="-12.1" /TU="U1029,U1030" /idTUdmin="U1030" /TUdmin="-6645" /isTUend="FALSE" promotor_-10 complement(1336610..1336622) /Source="Nicolas_upshift_promotors" /id="U1032" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.887112887112887" /psig="0.887112887112887" /xcortree=951 /SigmaFactorBS="aaccacgggtagacaatgttccatactgccaatatgccatcc caGGCATAGgcaaacaatcctaCTATAAAATTAATtacaggtacagcaacattatata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1336626) /Source="Nicolas_upshifts" /id="U1032" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.887112887112887" /psig="0.887112887112887" /xcortree=951 /SigmaFactorBS="aaccacgggtagacaatgttccatactgccaatatgccatcc caGGCATAGgcaaacaatcctaCTATAAAATTAATtacaggtacagcaacattatata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1336636..1336642) /Source="Nicolas_upshift_promotors" /id="U1032" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.887112887112887" /psig="0.887112887112887" /xcortree=951 /SigmaFactorBS="aaccacgggtagacaatgttccatactgccaatatgccatcc caGGCATAGgcaaacaatcctaCTATAAAATTAATtacaggtacagcaacattatata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1338957..1339616 /gene="xkdP" /locus_tag="BSU_12690" /old_locus_tag="BSU12690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; putative murein binding protein" /protein_id="NP_389151.2" /db_xref="EnsemblGenomes-Gn:BSU12690" /db_xref="EnsemblGenomes-Tr:CAB13126" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11550" /db_xref="UniProtKB/Swiss-Prot:P54335" /translation="MTKSVYEFWISQGKDKLRLPVLPDQLSISNTVQNETVKVAKFGD LTFIDEQGAKEISFSSFFPKKYSPIAEYQNFPSPENAITKIEKWMKAKKPVQFLITGT KVNLTCSIEGFSYSEGQQDIGDRSFDIQLKEYKTASPRKIKQKKKTKAKRPSKAAPKT YTVKKGDTLWDIAGRFYGNSTQWRKIWNANKTAMIKRSKRNIRQPGHWIFPGQKLKIP Q*" gene 1338957..1339616 /gene="xkdP" /locus_tag="BSU_12690" /old_locus_tag="BSU12690" CDS 1339632..1340609 /gene="xkdQ" /locus_tag="BSU_12700" /old_locus_tag="BSU12700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; conserved hypothetical protein" /protein_id="NP_389152.1" /db_xref="EnsemblGenomes-Gn:BSU12700" /db_xref="EnsemblGenomes-Tr:CAB13127" /db_xref="SubtiList:BG11551" /db_xref="UniProtKB/Swiss-Prot:P54336" /translation="MIELFVIKDTEWLELVAESVSLEGHRYQAPRSIEATIVTKQGDQ TYYSVSEGDTVLFKWKGKELFRGIVFARTPDEHTLAFSAYDMLQYLVKNQDMYVFSNQ RADQIIRRIASDFQIPTTSIANTGHTIKSLVIKNDTTLYDIILKALKQTKSQTGRHYQ LYSEKGKLGLRAWPDPSEVWVLETGVNITGYQYSTSINDTATRVVLRRQKDNKTYKAS AKDSSGLNKYGVLQYTETVTDDINQAQLQQRADVRLAEKKGVKKELKNIQAVGIPEVQ SGLPVYISIPEAGIKKTYWVDTDRHEFKGTKHTMTIDVVEKNTMPEGVS*" gene 1339632..1340609 /gene="xkdQ" /locus_tag="BSU_12700" /old_locus_tag="BSU12700" CDS 1340609..1340875 /gene="xkdR" /locus_tag="BSU_12710" /old_locus_tag="BSU12710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; conserved hypothetical protein" /protein_id="NP_389153.1" /db_xref="EnsemblGenomes-Gn:BSU12710" /db_xref="EnsemblGenomes-Tr:CAB13128" /db_xref="InterPro:IPR022555" /db_xref="SubtiList:BG11552" /db_xref="UniProtKB/Swiss-Prot:P54337" /translation="MRLSEAIKHLAVGAVDAESPVELLPAEVVSVSPVEIKLKENSKL IIPEDAIIIPKRMQSGGDDALEPGDRLMTAALTGGQSFFILDKV*" gene 1340609..1340875 /gene="xkdR" /locus_tag="BSU_12710" /old_locus_tag="BSU12710" CDS 1340932..1341357 /gene="xkdS" /locus_tag="BSU_12720" /old_locus_tag="BSU12720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; conserved hypothetical protein" /protein_id="NP_389154.1" /db_xref="EnsemblGenomes-Gn:BSU12720" /db_xref="EnsemblGenomes-Tr:CAB13129" /db_xref="InterPro:IPR020288" /db_xref="SubtiList:BG11553" /db_xref="UniProtKB/Swiss-Prot:P54338" /translation="MALTPEVEFEDIEVESEVIETSQTYKIDFENGRITNELITGLEA IRQFVYIALQTERYAYSIYSHNVGNELQDVLTDHETTDAYKKMEIPRLIEEALVYDDR ISAVTDFEIEKQGDAFHVSFVVETDEGTLEIEEVIGEDV*" gene 1340932..1341357 /gene="xkdS" /locus_tag="BSU_12720" /old_locus_tag="BSU12720" CDS 1341350..1342396 /gene="xkdT" /locus_tag="BSU_12730" /old_locus_tag="BSU12730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18077713; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; putative base plate assembly protein" /protein_id="NP_389155.1" /db_xref="EnsemblGenomes-Gn:BSU12730" /db_xref="EnsemblGenomes-Tr:CAB13130" /db_xref="InterPro:IPR006949" /db_xref="SubtiList:BG11554" /db_xref="UniProtKB/Swiss-Prot:P54339" /translation="MFEDQTFEAIMERMLNSISADIDTREGSVIYNALAPAAAELAKS YIWLDTVLELVFSDTAQGEFLDRRAAEAGIERTAATKAVRAGEFTSGVTIPVGSRFYV DNLYFQYTADGTLICETPGEAGNANLTGRNLLSLDTIPGLETAIVKEILIPGREEEGD DSLRERYFTRVRREAVSANKMHYKEWAEEVDGVGKAKIFPLWNGEGTVKIVVTNANLE PASPILIQKVKDYIDPEPGQGEGQAPIGAVVTVESAVWKEVEISAEVLPEINHSIDEV KSEIEEGVLNFFKKMAFEDNVIRLSQINNIVYNSPSVSDYSNIQINGTSENLVLSDVE IPKLGQVKIIEQTR*" gene 1341350..1342396 /gene="xkdT" /locus_tag="BSU_12730" /old_locus_tag="BSU12730" CDS 1342380..1342958 /gene="xkdU" /locus_tag="BSU_12740" /old_locus_tag="BSU12740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; conserved hypothetical protein" /protein_id="NP_389156.1" /db_xref="EnsemblGenomes-Gn:BSU12740" /db_xref="EnsemblGenomes-Tr:CAB13131" /db_xref="InterPro:IPR018755" /db_xref="SubtiList:BG11555" /db_xref="UniProtKB/Swiss-Prot:P54340" /translation="MSKQDDMRAYLPPFLTSLKEMAELLKAEAPEFDKQNDSIFDLTD QLFVPTATWGLSRWEKILNVPRESGDTDEIRRLRLISKMSNIPPITYRAIEQAVNRFL KNPSAQVRLLPGEYRFNVDINVDDLQHMNELIEAIENMKPAHLAYTLRGGLNETLRIK DTVILNHRRYRTASELKVGYSVTLNNNEVVLT*" gene 1342380..1342958 /gene="xkdU" /locus_tag="BSU_12740" /old_locus_tag="BSU12740" CDS 1342955..1343227 /gene="xkzA" /locus_tag="BSU_12749" /old_locus_tag="BSU12749" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; conserved hypothetical protein" /protein_id="YP_003097716.1" /db_xref="EnsemblGenomes-Gn:BSU12749" /db_xref="EnsemblGenomes-Tr:CAX52606" /db_xref="UniProtKB/Swiss-Prot:C0H3Z9" /translation="MISTIYRERTAADLKSRIDHVLLNGQKTEIVELAIDGATVTVLT KREEDIKHIETVQIFDELGNVITERKTDLDVSENRTLDFRFTFEVV*" gene 1342955..1343227 /gene="xkzA" /locus_tag="BSU_12749" /old_locus_tag="BSU12749" CDS 1343230..1345293 /gene="xkdV" /locus_tag="BSU_12750" /old_locus_tag="BSU12750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; conserved hypothetical protein" /protein_id="NP_389158.1" /db_xref="EnsemblGenomes-Gn:BSU12750" /db_xref="EnsemblGenomes-Tr:CAB13132" /db_xref="InterPro:IPR008983" /db_xref="SubtiList:BG11556" /db_xref="UniProtKB/Swiss-Prot:P54341" /translation="MAYEEKTDWLPDDPINEDDVNRWEKGIKDAHTDLAAHKNDMNNP HNTTKAQIGLGNVDNVQQASKTEFNEHNHDSTRHITSVERDEWNAKETPAGAQYKADQ AEANAKAYTDNFAARRDNPNQVTKAQVGLGNVENVKQASLADFDAHLSNSKVHVSEGE RNKWNAAQLIKLTGDDGKRIQLQDGTDILTLSSGFYCAVGQSVVNNPVEGDAAWYNYD IVEGGSGRKTIVAYQSWGSMMWIGMVHTDGEFRGWKQIATTDFIDRVQTELDLHENDK TNPHSVTKQQVGLGNVENVKQETPDGAQKKADTALNQSKDYTNSTAFITRPLNSITDA NDLNLPPGTYRLDTNYMNANPVLQNQFPLNDNRTGLLIIYPSANKWATRQDWFSISTK TLYTRVAVNGTDYSGWYILENSEGSQNKADKALADAKNYVETNYTNQKLTVLTGSNAI QDARISGNDYKYGITFMDIGANNTTGYPLTYGFVKNEKHSNYRFTQYFYGNADTTSGS YDHVGTWIRHWWADSGWTAWQKISGFAHANIGTTGRQALIKGENNKIKYNRIIKDSHK LFDTKNNRFVASHAGMHLVSASLYIENTERYSNFELYVYVNGTKYKLMNQFRMPTPSN NSDNEFNATVTGSVTVPLDAGDYVEIYVYVGYSGDVTRYVTDSNGALNYFDVLELGGR NYPRV*" gene 1343230..1345293 /gene="xkdV" /locus_tag="BSU_12750" /old_locus_tag="BSU12750" CDS 1345305..1345634 /gene="xkdW" /locus_tag="BSU_12760" /old_locus_tag="BSU12760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; conserved hypothetical protein" /protein_id="NP_389159.1" /db_xref="EnsemblGenomes-Gn:BSU12760" /db_xref="EnsemblGenomes-Tr:CAB13133" /db_xref="InterPro:IPR019094" /db_xref="InterPro:IPR035950" /db_xref="PDB:2HG7" /db_xref="SubtiList:BG11557" /db_xref="UniProtKB/Swiss-Prot:P54342" /translation="MILYDAIMYKYPNAVSRKDFELRNDGNGSYIEKWNLRAPLPTQA ELETWWEELQKNPPYEPPDQVELLAQELSQEKLARKQLEELNKTLGNELSDIKLSLLS LKGDYAE*" gene 1345305..1345634 /gene="xkdW" /locus_tag="BSU_12760" /old_locus_tag="BSU12760" CDS 1345631..1345795 /gene="xkdX" /locus_tag="BSU_12770" /old_locus_tag="BSU12770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; conserved hypothetical protein" /protein_id="NP_389160.1" /db_xref="EnsemblGenomes-Gn:BSU12770" /db_xref="EnsemblGenomes-Tr:CAB13134" /db_xref="InterPro:IPR010022" /db_xref="SubtiList:BG11558" /db_xref="UniProtKB/Swiss-Prot:P54343" /translation="MNYWVLALYYEWATTDMVKQALAYEDCSIQDLAEGVNKKLITAD QYKEITGKAM*" gene 1345631..1345795 /gene="xkdX" /locus_tag="BSU_12770" /old_locus_tag="BSU12770" CDS 1345839..1346678 /gene="xepA" /locus_tag="BSU_12780" /old_locus_tag="BSU12780" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7921239, 9555893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921239, 9555893; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; lytic exoenzyme" /protein_id="NP_389161.2" /db_xref="EnsemblGenomes-Gn:BSU12780" /db_xref="EnsemblGenomes-Tr:CAB13135" /db_xref="SubtiList:BG10959" /db_xref="UniProtKB/Swiss-Prot:P39797" /translation="MVKYQYEFPLDKAGKAGAVKPYRGGKNDFVTPVSNLSGVAEILT NAALKATEAYSQLGQDRLGAVLISKVKGWAYADREGTLFIEESDNNNVWTTTAAVNVA AGVLTATDWVYLSKRYYRFRYVNGNLQQSEFVLYQSVGAGEMDVRVNEKTPLQIDFAE NQTHDGRLKVEARKTFDFVFHENAESASEGAALPVDGAAHLLVEVYGTAEMSEVKFWG KSVSGQKLPIRGVKTDDATTASSTLGKAEAWAFDIKGFKEIIMEIISITGGTLSVKGT AVS*" gene 1345839..1346678 /gene="xepA" /locus_tag="BSU_12780" /old_locus_tag="BSU12780" misc_feature 1346685..1346703 /Source="Nicolas_upshift_promotors" /id="U1033" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.018981018981019" /xcortree=1520 /SigmaFactorBS="tatcaccggcggtactctttcggtaaaagggaccgcggtttc ataatagtctCGGCCCTCGGAAGGGAGGTgatctgcatgtgaaggaggagtgagagat g" /listShort="xhlA, xhlB, xlyA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1346693 /Source="Nicolas_upshifts" /id="U1033" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.018981018981019" /xcortree=1520 /SigmaFactorBS="tatcaccggcggtactctttcggtaaaagggaccgcggtttc ataatagtctCGGCCCTCGGAAGGGAGGTgatctgcatgtgaaggaggagtgagagat g" /listShort="xhlA, xhlB, xlyA" /GFF_Attribute="listLong" CDS 1346731..1347000 /gene="xhlA" /locus_tag="BSU_12790" /old_locus_tag="BSU12790" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7921239, 9555893, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921239, 9555893, 22720735; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; putative enzyme" /protein_id="NP_389162.1" /db_xref="EnsemblGenomes-Gn:BSU12790" /db_xref="EnsemblGenomes-Tr:CAB13136" /db_xref="GOA:P39798" /db_xref="InterPro:IPR019715" /db_xref="SubtiList:BG10960" /db_xref="UniProtKB/Swiss-Prot:P39798" /translation="MQQEADVNVFQQDLADMKGEHKALEQRVSALERVSDRQDQQIMT LNEKLNKIEENTTWIKRTITGAIITAVSTGIIGGAIAIMYSLLQH*" gene 1346731..1347000 /gene="xhlA" /locus_tag="BSU_12790" /old_locus_tag="BSU12790" CDS 1347013..1347276 /gene="xhlB" /locus_tag="BSU_12800" /old_locus_tag="BSU12800" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:2110147, 9555893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110147, 9555893; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; holin" /protein_id="NP_389163.1" /db_xref="EnsemblGenomes-Gn:BSU12800" /db_xref="EnsemblGenomes-Tr:CAB13137" /db_xref="GOA:Q99163" /db_xref="InterPro:IPR006479" /db_xref="SubtiList:BG10961" /db_xref="UniProtKB/Swiss-Prot:Q99163" /translation="MNTFDKGTVIRTVLLLIALINQTMLMLGKSPLDIQEEQVNQLAD ALYSAGSIAFTIGTTLAAWFKNNYVTEKGKKQRDLLRDNNLTK*" gene 1347013..1347276 /gene="xhlB" /locus_tag="BSU_12800" /old_locus_tag="BSU12800" CDS 1347289..1348182 /gene="xlyA" /locus_tag="BSU_12810" /old_locus_tag="BSU12810" /EC_number="3.5.1.28" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7921239, 9555893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921239, 9555893; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_389164.1" /db_xref="EnsemblGenomes-Gn:BSU12810" /db_xref="EnsemblGenomes-Tr:CAB13138" /db_xref="GOA:P39800" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR002502" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="InterPro:IPR036505" /db_xref="InterPro:IPR036779" /db_xref="PDB:3HMB" /db_xref="PDB:3RDR" /db_xref="SubtiList:BG10962" /db_xref="UniProtKB/Swiss-Prot:P39800" /translation="MVNIIQDFIPVGANNRPGYAMTPLYITVHNTANTAVGADAAAHA RYLKNPDTTTSWHFTVDDTEIYQHLPLNENGWHAGDGNGSGNRASIGIEICENADGDF AKATANAQWLIKTLMAEHNISLANVVPHKYWSGKECPRKLLDTWDSFKAGIGGGGSQT YVVKQGDTLTSIARAFGVTVAQLQEWNNIEDPNLIRVGQVLIVSAPSAAEKPELYPLP DGIIQLTTPYTSGEHVFQVQRALAALYFYPDKGAVNNGIDGVYGPKTADAVARFQSVN GLTADGIYGPATKEKIAAQLS*" gene 1347289..1348182 /gene="xlyA" /locus_tag="BSU_12810" /old_locus_tag="BSU12810" downshifts 1348191 /Source="Nicolas_upshifts" /id="D696" /incds=0 /nref=29 /ntot=162 /MaxReadThrough="3.77255" /MaxDrop="5.00305" /score="30.9009227" /energy="-12.5" /TU="U1029,U1033" /idTUdmin="U1029" /TUdmin="-152" /isTUend="FALSE" S_feature complement(1348200..1348403) /Source="Nicolas_S_feature" /locus_tag="new_1348200_1348403_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.798" /TUlongSig="NA" /TUlongPSig="NA" /label="S458" CDS complement(1348219..1348356) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type r: regulator" /codon_start=1 /transl_table=11 /product="three component toxin / antitoxin / antitoxin SpoIISABC, antitoxin C" /protein_id="YP_009513952.1" /translation="MSGDTVKKLVRRVKFVDYGRFGLSGYSLRVRERSAGIIKKLKKK K*" gene complement(1348219..1348356) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" downshifts complement(1348243) /Source="Nicolas_upshifts" /id="D697" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="2.75573" /MaxDrop="4.3776" /score="24.0186344" /energy="-12.5" /TU="U1034" /idTUdmin="U1035" /TUdmin=0 /isTUend="TRUE" CDS complement(1348442..1348612) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptotic control system component B (antitoxin B)" /protein_id="NP_389165.1" /db_xref="EnsemblGenomes-Gn:BSU12820" /db_xref="EnsemblGenomes-Tr:CAB13139" /db_xref="GOA:O34800" /db_xref="InterPro:IPR025897" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12678" /db_xref="UniProtKB/Swiss-Prot:O34800" /translation="MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKEN ERLIDEYKRKKA*" gene complement(1348442..1348612) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" downshifts complement(1348448) /Source="Nicolas_upshifts" /id="D698" /incds=0 /nref=6 /ntot=86 /MaxReadThrough="4.69899" /MaxDrop="3.0872" /score="24.0186344" /energy="-12.5" /TU="U1034,U1035" /idTUdmin="U1035" /TUdmin="-205" /isTUend="FALSE" CDS complement(1348612..1349358) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptosis factor (ABC toxin/antitoxin/antitoxin system)" /protein_id="NP_389166.1" /db_xref="EnsemblGenomes-Gn:BSU12830" /db_xref="EnsemblGenomes-Tr:CAB13140" /db_xref="GOA:O34853" /db_xref="InterPro:IPR025940" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12677" /db_xref="UniProtKB/Swiss-Prot:O34853" /translation="MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLL FVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAFIFLSAYVKKLAGSELETDTREI LEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSD SIVTEFDYLLFTSLTSIYDLVLPIEEEGEG*" gene complement(1348612..1349358) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" promotor_-10 complement(1349193..1349212) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1349210) /Source="Nicolas_upshifts" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" promotor_-35 complement(1349228..1349235) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1349384..1349402) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1349397) /Source="Nicolas_upshifts" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" promotor_-35 complement(1349418..1349423) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1349468..1350469) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10784039, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative low-affinity inorganic phosphate transporter" /protein_id="NP_389167.2" /db_xref="EnsemblGenomes-Gn:BSU12840" /db_xref="EnsemblGenomes-Tr:CAB13141" /db_xref="GOA:O34436" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13226" /db_xref="UniProtKB/Swiss-Prot:O34436" /translation="MDILLILTILIVICALAFDFINGFHDTANAIATSVSTKALKPRH AIILAAVMNFVGAMTFTGVAKTITKDIVDPYTLENGSVVILAALLAAIAWNLITWYYG IPSSSSHAIIGAIAGAAIAAAGFAALNYKGFIKIIEALILSPIIAFVLGFILYSIVKL IFKDSNLAKTNKQFRRVQIVTAALQSYTHGTNDAQKAMGIITMALITANLHTSANDIP TWVQFACATAMGLGTSIGGWKIIKTVGGKIMKIRPVNGVSADLTGAAIIFGATFIHLP VSTTHVISSSILGVGASHRVKGVNWGTAKRMLITWVITLPISATLGAIAYFILNMIF* " gene complement(1349468..1350469) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" downshifts complement(1349497) /Source="Nicolas_upshifts" /id="D699" /incds=0 /nref=205 /ntot=253 /MaxReadThrough="3.49591" /MaxDrop="5.81942" /score="21.8061263" /energy="-11" /TU="U1036,U1038" /idTUdmin="U1037" /TUdmin=0 /isTUend="TRUE" CDS complement(1350482..1351099) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696772, 14563871; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PitB transporter accessory protein" /protein_id="NP_389168.1" /db_xref="EnsemblGenomes-Gn:BSU12850" /db_xref="EnsemblGenomes-Tr:CAB13142" /db_xref="InterPro:IPR018445" /db_xref="SubtiList:BG13225" /db_xref="UniProtKB/Swiss-Prot:O34454" /translation="MIRRKKDKFSLLLTEIAKNIDETAEYFVNFKVTNQTTLKEFADT LKEYETKGDNHVHVMIKELNKAFITPIEREDILQLTNSLDDVLDGIEHFSAMMEIFSI TSSDEHIDKFSGYIRECAKEILITIELLAENRLKDIQPHAIKIKEYEHSCDNLHRKSL KNLFGNETDPIKVIQYREIYETLEEIADSCQSVANNLETIIMKNA*" gene complement(1350482..1351099) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" promotor_-10 complement(1351135..1351154) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1351137) /Source="Nicolas_upshifts" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" S_feature complement(1351139..1351236) /Source="Nicolas_S_feature" /locus_tag="new_1351139_1351236_c" /HighExp="H2O2, Etha, dia15, Diami, Paraq, Heat, dia5, Salt, LBGstat, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.972, 0.987" /TUlongSig="SigA" /TUlongPSig="0.992" /label="S459" promotor_-35 complement(1351170..1351174) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1351216..1351235) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1351236) /Source="Nicolas_upshifts" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" promotor_-35 complement(1351250..1351257) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1351281..1351300) /Source="Nicolas_upshift_promotors" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1351293) /Source="Nicolas_upshifts" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" CDS complement(1351375..1352691) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17344220, 19419962, 20610400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17344220, 19419962, 20610400; Product type t : transporter" /codon_start=1 /transl_table=11 /product="serine / threonine exchanger" /protein_id="NP_389169.1" /db_xref="EnsemblGenomes-Gn:BSU12860" /db_xref="EnsemblGenomes-Tr:CAB13143" /db_xref="GOA:O34739" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG13227" /db_xref="UniProtKB/Swiss-Prot:O34739" /translation="MHTEDNGLKKEIGLLFALTLVIGTIIGSGVFMKPGAVLAYSGDS KMALFAWLLGGILTLAGGLTIAEIGTQIPKTGGLYTYLEEVYGEFWGFLCGWVQIIIY GPAIIGALGLYFGSLMANLFGWGSGLSKVIGIIAVLFLCVINIIGTKYGGFVQTLTTI GKLIPIACIIVFGLWKGDQHIFTAVNESISDMNFGAAILATLFAYDGWILLAALGGEM KNPEKLLPRAMTGGLLIVTAIYIFINFALLHILSANEIVTLGENATSTAATMLFGSIG GKLISVGIIVSIFGCLNGKVLSFPRVSFAMAERKQLPFAEKLSHVHPSFRTPWIAISF QIALALIMMLISNPDKLSEISIFMIYIFYVMAFFAVFILRKRAKGEKRAYSVPLYPFM PILAIAGSFFVLGSTLITDTMSCGLSILIGLAGLPVYYGMKKRKAS*" gene complement(1351375..1352691) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" downshifts complement(1351390) /Source="Nicolas_upshifts" /id="D700" /incds=0 /nref=3 /ntot=92 /MaxReadThrough="3.59461" /MaxDrop="3.97157" /score="23.3119204" /energy="-14.4" /TU="U1039" /idTUdmin="U1039" /TUdmin="-88" /isTUend="FALSE" promotor_-10 complement(1352738..1352757) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-10" upshifts complement(1352754) /Source="Nicolas_upshifts" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" promotor_-35 complement(1352772..1352775) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-35" promotor_-35 1352974..1352981 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1352996..1353015 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1353008..1353079 /Source="Nicolas_S_feature" /locus_tag="new_1353008_1353079" /HighExp="Etha, dia15, Salt, Heat, dia5, Diami, H2O2, M9-stat, MG 25, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.964" /TUlongSig="NA" /TUlongPSig="NA" /label="S460" upshifts 1353008 /Source="Nicolas_upshifts" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" CDS 1353080..1354030 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" /EC_number="1.13.11.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17407181, 17725564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 17725564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroquinone-specific extradiol dioxygenase" /protein_id="NP_389170.1" /db_xref="EnsemblGenomes-Gn:BSU12870" /db_xref="EnsemblGenomes-Tr:CAB13144" /db_xref="GOA:O34689" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13228" /db_xref="UniProtKB/Swiss-Prot:O34689" /translation="MKVNGIHHVSALTADAQKNLDFYKKVLGLKLVKKSVNQDEPTMY HLFYGDEVANPGTELTFFEIPRIAPFHAGTNSISSIGLRVPGTEALHYWKERFEEQQV THSGISKRAGRDILAFQDHEGQRLVLTADEEGKGYGLPVKQSGIPEEFSFRGLGPVEL TVPYAEPTLHVLTNILGFTEISREPVEGQGTAVILESGEGGAATEIHLIERNDLPRER QGKGSVHHVAFRVRDEEELAGWHRIISREGFSNSGIVERYYFKALYFREPNGILFELS TDGPGFMVDENLDELGQTIALPPYLEHRRAEIEAKLKPIQ*" gene 1353080..1354030 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" downshifts 1354018 /Source="Nicolas_upshifts" /id="D701" /incds=0 /nref=95 /ntot=231 /MaxReadThrough="0.70251" /MaxDrop="5.11652" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1040" /TUdmin="-2" /isTUend="TRUE" CDS 1354131..1354277 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513953.1" /translation="MLIGRNGLKPFANMGDWYGMASAKILSLFINSLFIFACYTISKL DKKE*" gene 1354131..1354277 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" CDS 1354285..1356435 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane glycosyl transferase" /protein_id="NP_389171.2" /db_xref="EnsemblGenomes-Gn:BSU12880" /db_xref="EnsemblGenomes-Tr:CAB13145" /db_xref="GOA:O34575" /db_xref="SubtiList:BG13229" /db_xref="UniProtKB/Swiss-Prot:O34575" /translation="MEKKKRELDIVLLLILLASAFLNIYNIWKDDTVNPYYTAAVTSM MQSFHNFFYASFDAAGFITVDKPPVTYQIQTISALIFGMHGWSVILPQALAGVGSVLL MYLLIKPTFGKTAARIASFVMACTPIAVAVARTNNVDALLVFFLLLATWLLFKAIRKG KLIWLLAAFFVVGVGFNTKMLQAYMILPAFLLFYLIAANATIKKKIVSLVSALAVLAA VSLSWPLIVDNIPASKRPYIGSSQTNSVLELAFGYNGIQRLTGQNSGGGQGAPNKDAS KEMSSSDNTQAPPNQSSSNSSSSDGKSSNGNMAAPPSNGQMPSGGQGGPPSGGDGGQG GPGGDGGKGGTGTGSKMQSGSGMFGTGTPGPLRLFQQELSDQISWLLPFAIFGIAGLL IAGARERRRLSVEQKETVFWVAWLVPIAGFFSVAEFFHHYYLIMLAPPIAALVGAGWV ALVHLYRNQTGWKAWLLPGAIIATTGFELFILRNYNDQIGVGWSIGVGVIGVLSAIAL LLFKQRQKPFSYYVSLAALLALLVMPMYWASTPLLYGGNSSLPETGPQLASMSGKGMG MSDATVNEKLIKYLEENNSGAEYLFATTDSNTAAPYIIKTKKAVMAIGGYSGSDPAIT LTQFKKLVKEGKVKYFLASGMGRGGNNDIVEWVEKNGKEVASEKWQSSSDQKTENTDS ADTSSSKASGENGKMGGPGGMNQSATLYELHADE*" gene 1354285..1356435 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" promotor_no_box 1355174..1355274 /Source="Nicolas_upshift_promotors" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1355234 /Source="Nicolas_upshifts" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1355322 /Source="Nicolas_upshifts" /id="D702" /incds=1 /nref=4 /ntot=10 /MaxReadThrough="0.56615" /MaxDrop="4.44711" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1041" /TUdmin=0 /isTUend="TRUE" CDS 1356447..1357418 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" /EC_number="2.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389172.2" /db_xref="EnsemblGenomes-Gn:BSU12890" /db_xref="EnsemblGenomes-Tr:CAB13146" /db_xref="GOA:O34319" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13230" /db_xref="UniProtKB/Swiss-Prot:O34319" /translation="MSRHIQYSIVVPVYNEELVIHETYQRLKEVMDQTKENYELLFVN DGSKDRSIEILREHSLIDPRVKIIDFSRNFGHQIAITAGMDYAQGNAIVVIDADLQDP PELILEMIEKWKEGYEVVYAVRTKRKGETFFKKQTAAMFYRLLSGMTDIDIPIDTGDF RLMDRKVCDEMKRLKEKNPFVRGLVSWVGFKQTAVEYVRDERLAGETKYPLKKMLKLS MDGITTFSHKPLKLASYAGILMSGTGFLYMFIVLYLKLFTDSTITGWSSLIVIQLLFS GIVLLILGVIGEYIGRIYDEAKDRPLYIVQKSYGIENKRLYRDQHMS*" gene 1356447..1357418 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" S_feature complement(1356775..1357416) /Source="Nicolas_S_feature" /locus_tag="new_1356775_1357416_c" /HighExp="T-0.40H, T0.0H, Salt, T0.30H, T-1.10H, C30, T-1.40H, S0, H2O2, T1.0H" /AntisenseName="ykcC" /AntisenseCor="9.6017422892053297E-4" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S461" downshifts complement(1357461) /Source="Nicolas_upshifts" /id="D703" /incds=0 /nref=9 /ntot=114 /MaxReadThrough="4.36795" /MaxDrop="4.15844" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=489 /isTUend="FALSE" S_feature complement(1357486..1357852) /Source="Nicolas_S_feature" /locus_tag="new_1357486_1357852_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T0.0H, T2.30H, T-0.40H, T3.0H, Salt, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99893799999999999" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S462" downshifts complement(1357529) /Source="Nicolas_upshifts" /id="D704" /incds=0 /nref=17 /ntot=157 /MaxReadThrough="6.61192" /MaxDrop="3.74411" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=421 /isTUend="FALSE" promotor_-10 complement(1357832..1357847) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1357852) /Source="Nicolas_upshifts" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" promotor_-35 complement(1357859..1357868) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1357936..1359285) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" /EC_number="3.4.21.107" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 11555295, 12823817, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 11555295, 12823817, 24362423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound serine protease Do, quality control protease and chaperone (heat-shock protein)" /protein_id="NP_389173.2" /db_xref="EnsemblGenomes-Gn:BSU12900" /db_xref="EnsemblGenomes-Tr:CAB13147" /db_xref="GOA:O34358" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG12608" /db_xref="UniProtKB/Swiss-Prot:O34358" /translation="MDNYRDENRTKGNENEVFLTKENDQSASYSARNVIHDQEKKKRG FGWFRPLLGGVIGGSLALGIYTFTPLGDHDSQDTAKQSSSQQQTQSVTATSTSSESKK SSSSSSAFKSEDSSKISDMVEDLSPAIVGITNLQAQSNSSLFGSSSSDSSEDTESGSG SGVIFKKENGKAYIITNNHVVEGASSLKVSLYDGTEVTAKLVGSDSLTDLAVLQISDD HVTKVANFGDSSDLRTGETVIAIGDPLGKDLSRTVTQGIVSGVDRTVSMSTSAGETSI NVIQTDAAINPGNSGGPLLNTDGKIVGINSMKISEDDVEGIGFAIPSNDVKPIAEELL SKGQIERPYIGVSMLDLEQVPQNYQEGTLGLFGSQLNKGVYIREVASGSPAEKAGLKA EDIIIGLKGKEIDTGSELRNILYKDAKIGDTVEVKILRNGKEMTKKIKLDQKEEKTS* " gene complement(1357936..1359285) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" downshifts complement(1357950) /Source="Nicolas_upshifts" /id="D705" /incds=0 /nref=198 /ntot=244 /MaxReadThrough="2.95586" /MaxDrop="5.35972" /score="30.7234179" /energy="-19.9" /TU="NA" /idTUdmin="U1044" /TUdmin=0 /isTUend="TRUE" promotor_-35 1359325..1359332 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-35" promotor_-10 complement(1359337..1359356) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1359345 /Source="Nicolas_upshifts" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" promotor_-10 1359347..1359366 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-10" upshifts complement(1359355) /Source="Nicolas_upshifts" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" S_feature complement(1359357..1359439) /Source="Nicolas_S_feature" /locus_tag="new_1359357_1359439_c" /HighExp="Etha, dia5, S8, S6, T2.0H, T3.30H, dia15, T5.0H, BC, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.682" /TUlongSig="NA" /TUlongPSig="NA" /label="S463" promotor_-35 complement(1359367..1359374) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1359396..1359402 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1359417..1359436 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1359420 /Source="Nicolas_upshifts" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" promotor_-10 complement(1359422..1359441) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1359439) /Source="Nicolas_upshifts" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" CDS 1359454..1360272 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" /EC_number="1.5.1.2" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redundant pyrroline-5-carboxylate reductase" /protein_id="NP_389174.1" /db_xref="EnsemblGenomes-Gn:BSU12910" /db_xref="EnsemblGenomes-Tr:CAB13148" /db_xref="GOA:Q00777" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10841" /db_xref="UniProtKB/Swiss-Prot:Q00777" /translation="MEQIGLIGYGSMADMIARQLLKHEQIKENELFIETRTKGERLRA LMSDYPNVSADPLENWANTCQLILICVPPLHVIETMRRLYPYVNRNTHIVSIAAGVPL RLLEAETEAGISRVIPAITSEAEAGISLVVHSEALAAEKKERLNELLSVFSRVREIKE SNLDVASNLTSSAPGFIAAIFEELALSAVRNSSLSKEEAFDFLIHSLYGTGKMLIEKN MSFEETLERVATKGGITGEGAEVIHASVPDVFDEVFERTLRKYELLTEQVGKQT*" gene 1359454..1360272 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" promotor_-35 complement(1359457..1359460) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1360250 /Source="Nicolas_upshifts" /id="D706" /incds=0 /nref=90 /ntot=220 /MaxReadThrough="1.3818" /MaxDrop="4.43155" /score="-5.08770006" /energy="-5.3" /TU="NA" /idTUdmin="U1045" /TUdmin=0 /isTUend="TRUE" promotor_-35 1360329..1360336 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1360351..1360370 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1360355 /Source="Nicolas_upshifts" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" CDS 1360401..1361225 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11069674, 11473256, 19340926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069674, 11473256, 19340926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-aminopeptidase" /protein_id="NP_389175.2" /db_xref="EnsemblGenomes-Gn:BSU12920" /db_xref="EnsemblGenomes-Tr:CAB13149" /db_xref="GOA:P26902" /db_xref="InterPro:IPR007035" /db_xref="InterPro:IPR027476" /db_xref="InterPro:IPR033824" /db_xref="InterPro:IPR036177" /db_xref="PDB:1HI9" /db_xref="SubtiList:BG10842" /db_xref="UniProtKB/Swiss-Prot:P26902" /translation="MKLYMSVDMEGISGLPDDTFVDSGKRNYERGRLIMTEEANYCIA EAFNSGCTEVLVNDSHSKMNNLMVEKLHPEADLISGDVKPFSMVEGLDDTFRGALFLG YHARASTPGVMSHSMIFGVRHFYINDRPVGELGLNAYVAGYYDVPVLMVAGDDRAAKE AEELIPNVTTAAVKQTISRSAVKCLSPAKAGRLLTEKTAFALQNKDKVKPLTPPDRPV LSIEFANYGQAEWANLMPGTEIKTGTTTVQFQAKDMLEAYQAMLVMTELAMRTSFC*" gene 1360401..1361225 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" CDS 1361242..1362168 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389176.1" /db_xref="EnsemblGenomes-Gn:BSU12930" /db_xref="EnsemblGenomes-Tr:CAB13150" /db_xref="GOA:P26903" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10843" /db_xref="UniProtKB/Swiss-Prot:P26903" /translation="MARYMIKRFWAMAATILVITTLTFVLMKVIPGSPFNEERGTNEA VQKNLEAYYHLDDPLIFQYIFYLKSIITFDFGPSIKKPSDSVNDMLERGFPVSFELGM TAIVIAVISGLVLGVIAALRRNGFLDYAAMSLAVLGISIPNFILATLLIQQFAVNLKL FPAATWTSPIHMVLPTAALAVGPMAIIARLTRSSMVEVLTQDYIRTAKAKGLSPFKII VKHALRNALMPVITVLGTLVASILTGSFVIEKIFAIPGMGKYFVESINQRDYPVIMGT TVFYSVILIIMLFLVDLAYGLLDPRIKLHKKG*" gene 1361242..1362168 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" CDS 1362174..1363136 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389177.1" /db_xref="EnsemblGenomes-Gn:BSU12940" /db_xref="EnsemblGenomes-Tr:CAB13151" /db_xref="GOA:P26904" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10844" /db_xref="UniProtKB/Swiss-Prot:P26904" /translation="MNLPVQTDERQPEQHNQVPDEWFVLNQEKNREADSVKRPSLSYT QDAWRRLKKNKLAMAGLFILLFLFVMAVIGPFLSPHSVVRQSLTEQNLPPSADHWFGT DELGRDVFTRTWYGARISLFVGVMAALIDFLIGVIYGGVAGYKGGRIDSIMMRIIEVL YGLPYLLVVILLMVLMGPGLGTIIVALTVTGWVGMARIVRGQVLQIKNYEYVLASKTF GAKTFRIIRKNLLPNTMGAIIVQMTLTVPAAIFAESFLSFLGLGIQAPFASWGVMAND GLPTILSGHWWRLFFPAFFISLTMYAFNVLGDGLQDALDPKLRR*" gene 1362174..1363136 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" promotor_-35 1362868..1362873 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1362889..1362907 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1362890 /Source="Nicolas_upshifts" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" CDS 1363141..1364148 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7536291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7536291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (ATP-binding subunit)" /protein_id="NP_389178.1" /db_xref="EnsemblGenomes-Gn:BSU12950" /db_xref="EnsemblGenomes-Tr:CAB13152" /db_xref="GOA:P26905" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10845" /db_xref="UniProtKB/Swiss-Prot:P26905" /translation="MEKVLSVQNLHVSFTTYGGTVQAVRGVSFDLYKGETFAIVGESG CGKSVTSQSIMGLLPPYSAKVTDGRILFKNKDLCRLSDKEMRGIRGADISMIFQDPMT ALNPTLTVGDQLGEALLRHKKMSKKAARKEVLSMLSLVGIPDPGERLKQYPHQFSGGM RQRIVIAMALICEPDILIADEPTTALDVTIQAQILELFKEIQRKTDVSVILITHDLGV VAQVADRVAVMYAGKMAEIGTRKDIFYQPQHPYTKGLLGSVPRLDLNGAELTPIDGTP PDLFSPPPGCPFAARCPNRMVVCDRVYPGQTIRSDSHTVNCWLQDQRAEHAVLSGDAK D*" gene 1363141..1364148 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" CDS 1364151..1365800 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7783641, 8793880, 11390694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783641, 8793880, 11390694; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (dipeptide-binding lipoprotein)" /protein_id="NP_389179.2" /db_xref="EnsemblGenomes-Gn:BSU12960" /db_xref="EnsemblGenomes-Tr:CAB13153" /db_xref="GOA:P26906" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10846" /db_xref="UniProtKB/Swiss-Prot:P26906" /translation="MKRGKRMKRVKKLWGMGLALGLSFALMGCTANEQAGKEGSHDKA KTSGEKVLYVNNENEPTSFDPPIGFNNVSWQPLNNIMEGLTRLGKDHEPEPAMAEKWS VSKDNKTYTFTIRENAKWTNGDPVTAGDFEYAWKRMLDPKKGASSAFLGYFIEGGEAY NSGKGKKDDVKVTAKDDRTLEVTLEAPQKYFLSVVSNPAYFPVNEKVDKDNPKWFAES DTFVGNGPFKLTEWKHDDSITMEKSDTYWDKDTVKLDKVKWAMVSDRNTDYQMFQSGE LDTAYVPAELSDQLLDQDNVNIVDQAGLYFYRFNVNMEPFQNENIRKAFAMAVDQEEI VKYVTKNNEKPAHAFVSPGFTQPDGKDFREAGGDLIKPNESKAKQLLEKGMKEENYNK LPAITLTYSTKPEHKKIAEAIQQKLKNSLGVDVKLANMEWNVFLEDQKALKFQFSQSS FLPDYADPISFLEAFQTGNSMNRTGWANKEYDQLIKQAKNEADEKTRFSLMHQAEELL INEAPIIPVYFYNQVHLQNEQVKGIVRHPVGYIDLKWADKN*" gene 1364151..1365800 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" downshifts 1365794 /Source="Nicolas_upshifts" /id="D707" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="6.73127" /MaxDrop="3.5888" /score="22.838155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-4469" /isTUend="FALSE" CDS 1365888..1366847 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" /EC_number="3.4.17.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10428950, 15101989, 18535144, 20944232, 24123814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="muropeptide L,D-carboxypeptidase" /protein_id="NP_389180.2" /db_xref="EnsemblGenomes-Gn:BSU12970" /db_xref="EnsemblGenomes-Tr:CAB13154" /db_xref="GOA:O34851" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13231" /db_xref="UniProtKB/Swiss-Prot:O34851" /translation="MKGVFSLNYKPKALNKGDTVGVIAPASPPDPKKLDTALLFLEEL GLQVKLGKALKNQHGYLAGQDDERLADLHEMFRDDEVKAVLCACGGFGTGRIAAGIDF SLIRKHPKIFWGYSDITFLHTAIHQNTGLVTFHGPMLSTDIGLDDVHPLTKASYKQLF QETEFTYTEELSPLTELVPGKAEGELVGGNLSLLTSTLGTPFEIDTRGKLLFIEDIDE EPYQIDRMLNQLKMGGKLTDAAGILVCDFHNCVPVKREKSLSLEQVLEDYIISAGRPA LRGFKIGHCSPSIAVPIGAKAAMNTAEKTAVIEAGVSEGALKT*" gene 1365888..1366847 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" CDS 1366844..1367944 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" /EC_number="5.1.1.20" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11747447, 11747448, 15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11747447, 11747448, 15101989; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-Ala-D/L-Glu epimerase" /protein_id="NP_389181.1" /db_xref="EnsemblGenomes-Gn:BSU12980" /db_xref="EnsemblGenomes-Tr:CAB13155" /db_xref="GOA:O34508" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:1JPM" /db_xref="PDB:1TKK" /db_xref="SubtiList:BG13232" /db_xref="UniProtKB/Swiss-Prot:O34508" /translation="MKIIRIETSRIAVPLTKPFKTALRTVYTAESVIVRITYDSGAVG WGEAPPTLVITGDSMDSIESAIHHVLKPALLGKSLAGYEAILHDIQHLLTGNMSAKAA VEMALYDGWAQMCGLPLYQMLGGYRDTLETDYTVSVNSPEEMAADAENYLKQGFQTLK IKVGKDDIATDIARIQEIRKRVGSAVKLRLDANQGWRPKEAVTAIRKMEDAGLGIELV EQPVHKDDLAGLKKVTDATDTPIMADESVFTPRQAFEVLQTRSADLINIKLMKAGGIS GAEKINAMAEACGVECMVGSMIETKLGITAAAHFAASKRNITRFDFDAPLMLKTDVFN GGITYSGSTISMPGKPGLGIIGAALLKGEKEQ*" gene 1366844..1367944 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" CDS 1367941..1368831 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989, 20944232" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 20944232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamyl-L-diaminoacid endopeptidase" /protein_id="NP_389182.2" /db_xref="EnsemblGenomes-Gn:BSU12990" /db_xref="EnsemblGenomes-Tr:CAB13156" /db_xref="GOA:O35010" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG13233" /db_xref="UniProtKB/Swiss-Prot:O35010" /translation="MMHTVISAVANIWTAPDSPRPSDQFMLQPTVMIRDWLERMTYDE RLGLCTDNVIQTQVLFGEKVLVTAEQGEWVSVIVPSQPSRKDPRGYPGWMKKYQLEKT KPIHTQHDVMISKPAAFLYRSNGEKEIELSFLTVLPLIAKENGYFKVSTVFGERFVRQ SDAVPVSQQKGTAEDIIQTGAFFLGLPYLWGGISGFGFDCSGFMYSIFKANGYSIPRD AGDQAKAGKGVPLDDMKAGDLLFFAYEEGKGAIHHVGLYVGGGKMLHSPKTGKSIEIL TLTETIYEKELCAVRRCFSE*" gene 1367941..1368831 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" CDS 1368844..1369833 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cell wall oligopeptide ABC transporter (ATP binding protein)" /protein_id="NP_389183.2" /db_xref="EnsemblGenomes-Gn:BSU13000" /db_xref="EnsemblGenomes-Tr:CAB13157" /db_xref="GOA:C0SP98" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13234" /db_xref="UniProtKB/Swiss-Prot:C0SP98" /translation="MRRLPLLEVSQLKMHFDAGKKRTVKAVDGVTFQIREGETFGLVG ESGCGKSTLGRVLMRLYQPTEGSVTYRGTNLHALSEKEQFAFNRKLQMIFQDPYASLN PRMTVREIILEPMEIHNLYNTHKARLLVVDELLEAVGLHPDFGSRYPHEFSGGQRQRI GIARALSLNPEFIVADEPISALDVSVQAQVVNLLKRLQKEKGLTFLFIAHDLSMVKHI SDRIGVMYLGHMMEITESGTLYREPLHPYTKALLSSIPIPDPELEDKRERILLKGELP SPVNPPSGCVFRTRCPEAMPECGESRPQLQEIEPGRFVACHLYRNAETKEKVR*" gene 1368844..1369833 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" S_feature complement(1369127..1369854) /Source="Nicolas_S_feature" /locus_tag="new_1369127_1369854_c" /HighExp="Etha, S7, Gly, M40t90, C30, H2O2, M0t90, dia15, T1.0H, S8" /AntisenseName="ykfD" /AntisenseCor="-6.3474114158352593E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S464" downshifts 1369823 /Source="Nicolas_upshifts" /id="D708" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="5.08319" /MaxDrop="3.1399" /score="-3.10371155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-440" /isTUend="FALSE" S_feature 1369868..1371036 /Source="Nicolas_S_feature" /locus_tag="new_1369868_1371036" /HighExp="T3.30H, T4.0H, T3.0H, T5.0H, T2.30H, T2.0H, S1, M9-stat, T1.30H, HiOs" /AntisenseName="ykgB" /AntisenseCor="-0.33524952291190102" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S465" CDS complement(1369876..1370925) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" /EC_number="3.1.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22960854, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconolactonase" /protein_id="NP_389184.1" /db_xref="EnsemblGenomes-Gn:BSU13010" /db_xref="EnsemblGenomes-Tr:CAB13158" /db_xref="GOA:O34499" /db_xref="InterPro:IPR011048" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019405" /db_xref="SubtiList:BG13236" /db_xref="UniProtKB/Swiss-Prot:O34499" /translation="MTKYIGYVGTYTKGGSEGIYSFELDTEKKALSEPKLAAKLGNPT YVATNKNNTILYSIEKADGQGGVAAYQIDKNSGELTFLNHQLIDGPSPCHVSVDDQNQ FVLTANYHSGKVHVFPVQEDGSLQSPVSEAAHTGKGPHERQEKPHTHYAGFTPEHNYV VAVDLGIDKLYTYKLKDGVLTESGSHSFAPGAGPRHIAFHPKEKYAYVMTELSNEVIA LEYNPTAGEFREIQVVSAIPDDFTDNSQGSAIHVTQDGRFVYVANRGHDSIAVFEVNQ YSGELAFVERVSTEGNWPRDFVFDPTEGFLVASNEETGNLVLFERDKETGRLTLLPST VSVPYPVCVKFLHQV*" gene complement(1369876..1370925) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" downshifts complement(1369899) /Source="Nicolas_upshifts" /id="D709" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="5.12776" /MaxDrop="6.0668" /score="24.6986564" /energy="-15.6" /TU="U1050" /idTUdmin="U1049" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1370952..1370971) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1370963) /Source="Nicolas_upshifts" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" promotor_-35 complement(1370986..1370993) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1371015..1371875) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" /EC_number="3.5.3.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27258038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N(G),N(G)-dimethylarginine dimethylaminohydrolase" /protein_id="NP_389185.2" /db_xref="EnsemblGenomes-Gn:BSU13020" /db_xref="EnsemblGenomes-Tr:CAB13159" /db_xref="GOA:O34497" /db_xref="InterPro:IPR033199" /db_xref="SubtiList:BG13235" /db_xref="UniProtKB/Swiss-Prot:O34497" /translation="MDVSIPKSQHKTVCRTEYGTLQKVILCKPEHMTIKDVINETQKH FEDDNIHVKTANDQHSRLVEALRSHNVEVVLLPVRDGLPEQVFTRDIGFVIGEKAFLS SMTEPIRQGEEAVIKDFFHSQGISYTRMLDTSIEGGDVIIDDDIVYVGISQRTDISAI GQLEEALPEYTIVPVKLHEKFLHLDCVFNIISESEALIYSQAIEPDAADMLAKRYDLI EVPEDEQFTLGTNVLSIGKKTIISLPGNRHVNQQLSKRGYHIIEIDLSEIIKSGGSFR CCTMPLIRGE*" gene complement(1371015..1371875) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" promotor_-10 complement(1371900..1371918) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1371917) /Source="Nicolas_upshifts" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" promotor_-35 complement(1371934..1371940) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1371949..1371956 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1371970..1371989 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1371977 /Source="Nicolas_upshifts" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" CDS 1372035..1372553 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" /EC_number="3.1.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12426338, 18247525, 24623648, 24722906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acyl-CoA thioesterase" /protein_id="NP_389186.2" /db_xref="EnsemblGenomes-Gn:BSU13030" /db_xref="EnsemblGenomes-Tr:CAB13160" /db_xref="GOA:P49851" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR033120" /db_xref="SubtiList:BG11417" /db_xref="UniProtKB/Swiss-Prot:P49851" /translation="METPETRFCKESKVVKTSRVFPLDTNNHNTLFGGKLMSYIDDIA SISAARHCRRETVTASMDSVDFLKPIGQKDSVCLESYVTWVGTSSMEVFVKVIKEHLM TGERELAATSFLTFVALDSNGKPVPVPRVVPETEEEIMLHNTAVQRANERKNRKRHSQ ALANALGTDKPW*" gene 1372035..1372553 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" downshifts 1372544 /Source="Nicolas_upshifts" /id="D710" /incds=0 /nref=34 /ntot=265 /MaxReadThrough="4.66856" /MaxDrop="4.77681" /score="24.0889455" /energy="-10.9" /TU="U1051" /idTUdmin="U1051" /TUdmin="-1436" /isTUend="FALSE" promotor_-35 1372618..1372624 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-35" S_feature 1372636..1372742 /Source="Nicolas_S_feature" /locus_tag="new_1372636_1372742" /HighExp="Etha, S5, S6, S8, nit, S7, ferm, S4, dia15, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S466" upshifts 1372636 /Source="Nicolas_upshifts" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" promotor_-10 1372638..1372649 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-10" promotor_-35 1372717..1372720 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1372736..1372755 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1372744 /Source="Nicolas_upshifts" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" CDS 1372792..1373991 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044; Product type c: carrier" /codon_start=1 /transl_table=11 /product="flavohemoglobin" /protein_id="NP_389187.1" /db_xref="EnsemblGenomes-Gn:BSU13040" /db_xref="EnsemblGenomes-Tr:CAB13161" /db_xref="GOA:P49852" /db_xref="InterPro:IPR000971" /db_xref="InterPro:IPR001221" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR008333" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023950" /db_xref="SubtiList:BG11418" /db_xref="UniProtKB/Swiss-Prot:P49852" /translation="MLDNKTIEIIKSTVPVLQQHGETITGRFYDRMFQDHPELLNIFN QTNQKKKTQRTALANAVIAAAANIDQLGNIIPVVKQIGHKHRSIGIKPEHYPIVGKYL LIAIKDVLGDAATPDIMQAWEKAYGVIADAFIGIEKDMYEQAEEQAGGWKEYKPFVIA KKERESKEITSFYLKPEDSKPLPEFQAGQYISIKVRIPDSEYTHIRQYSLSDMPGKDY YRISVKKDGVVSSYLHDGLQEGDSIEISAPAGDFVLDHASQKDLVLISAGVGITPMIS MLKTSVSKQPERQILFIHAAKNSEYHALRHEVEEAAKHSAVKTAFVYREPTEEDRAGD LHFHEGQIDQQFLKELIANTDADYYICGSPSFITAMHKLVSELGSAPESIHYELFGPQ LSLAQSV*" gene 1372792..1373991 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" downshifts 1373980 /Source="Nicolas_upshifts" /id="D711" /incds=0 /nref=10 /ntot=59 /MaxReadThrough="6.06442" /MaxDrop="4.19301" /score="11.2868967" /energy="-9.3" /TU="U1053" /idTUdmin="U1051" /TUdmin=0 /isTUend="TRUE" S_feature 1374025..1374396 /Source="Nicolas_S_feature" /locus_tag="new_1374025_1374396" /HighExp="nit, B36, B60, Etha, BI, M40t90, LBGtran, M0t90, BT, S6" /AntisenseName="ykzH" /AntisenseCor="7.6554747052539299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="SigGF" /TUlongPSig="0.998" /label="S467" CDS complement(1374068..1374292) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389188.1" /db_xref="EnsemblGenomes-Gn:BSU13050" /db_xref="EnsemblGenomes-Tr:CAB13162" /db_xref="SubtiList:BG13336" /db_xref="UniProtKB/Swiss-Prot:O31653" /translation="MKNQKSNTLWPFDLPLAPQPEGYQQQTIDRLAGLELRMKQLIRA IEVNNELLRTMQEQQNRVCTNGSGSVIVRM*" gene complement(1374068..1374292) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" promotor_-35 1374372..1374378 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1374392..1374403 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1374398 /Source="Nicolas_upshifts" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" CDS 1374437..1375168 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389189.1" /db_xref="EnsemblGenomes-Gn:BSU13060" /db_xref="EnsemblGenomes-Tr:CAB13163" /db_xref="GOA:P49853" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG11419" /db_xref="UniProtKB/Swiss-Prot:P49853" /translation="MLWMVWVFLLKPVIVFSIAYILFRLAGKKAVSQMNNFDLLLTFA IGTIISEPILTSKLPMSIYYAGAFLVLYLIMSKLSLSNKWRWLLVVSPTVLIRNGDID ERGLRKERLTVNELLGKLREKGYADPADIDLAIIEETGEVSVIPKEEARAVQVRDLNM EAERNFIPIPLILDGEILDHNLKYLQKNRSWLFEKLEEKGYSPKLLSSIILGTMNARG DISLDLNTANEPQHDPYLYKPGNNN*" gene 1374437..1375168 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" downshifts 1375146 /Source="Nicolas_upshifts" /id="D712" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="2.84532" /MaxDrop="4.44655" /score="17.2468985" /energy="-7.2" /TU="U1053" /idTUdmin="U1054" /TUdmin=0 /isTUend="TRUE" promotor_-35 1375207..1375215 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1375226..1375244 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1375234 /Source="Nicolas_upshifts" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" CDS 1375260..1375787 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389190.1" /db_xref="EnsemblGenomes-Gn:BSU13070" /db_xref="EnsemblGenomes-Tr:CAB13164" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG11420" /db_xref="UniProtKB/Swiss-Prot:P49854" /translation="MKDLSIRNDMAPTVSLLYSAVEENSLRLASIVSHMTHSELYYKG RCQTKNSTAQLLHHITNVDIRWVWRIKENRIPDHIEQAYGPMTDESGRLPEPVNQPDL DELLKRHQHVVEKLKSVCFTLTENALNQPLSFEGDTATIRWGIWHMADHNRYHQAHIE ALKKEWKQDVAKYER*" gene 1375260..1375787 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" CDS 1375777..1376295 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389191.1" /db_xref="EnsemblGenomes-Gn:BSU13080" /db_xref="EnsemblGenomes-Tr:CAB13165" /db_xref="GOA:P49855" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11421" /db_xref="UniProtKB/Swiss-Prot:P49855" /translation="MNAKTKLVTDRIRLRCMEDRDQATLFGLLFNDPDVMTYYSGLKD KRQTREWVNWNQRNEKGYGVSLWIAEDKRTGEFLGQCGIVPQQIENQTVMEIGYMFAR RHWGNGYAQEAARACLDYGFNERQFGKMAALIDPGNKASIRVAEKIGMHYSKTIRKWN KPIAVYERKSYN*" gene 1375777..1376295 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" promotor_-35 1376289..1376296 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-35" promotor_-10 1376310..1376329 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-10" upshifts 1376313 /Source="Nicolas_upshifts" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" misc_RNA 1376328..1376439 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" /product="guanidine-sensing riboswitch (binds free guanidinium)" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17908319, 21317561, 27989440, 28001368, 28017522, 28107646, 28212758; Product type n: RNA" gene 1376328..1376439 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" downshifts 1376402 /Source="Nicolas_upshifts" /id="D713" /incds=0 /nref=205 /ntot=246 /MaxReadThrough="3.70824" /MaxDrop="6.58389" /score="30.3456563" /energy="-18.5" /TU="U1056" /idTUdmin="U1056" /TUdmin="-789" /isTUend="FALSE" CDS 1376517..1376855 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389192.1" /db_xref="EnsemblGenomes-Gn:BSU13090" /db_xref="EnsemblGenomes-Tr:CAB13166" /db_xref="GOA:P49856" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11422" /db_xref="UniProtKB/Swiss-Prot:P49856" /translation="MKWGLVVLAAVFEVVWVIGLKHADSALTWSGTAIGIIFSFYLLM KATHSLPVGTVYAVFTGLGTAGTVLSEIVLFHEPVGWPKLLLIGVLLIGVIGLKLVTQ DETEEKGGEA*" gene 1376517..1376855 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" CDS 1376855..1377172 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389193.1" /db_xref="EnsemblGenomes-Gn:BSU13100" /db_xref="EnsemblGenomes-Tr:CAB13167" /db_xref="GOA:P49857" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11423" /db_xref="UniProtKB/Swiss-Prot:P49857" /translation="MLHWISLLCAGCLEMAGVALMNQYAKEKSVKWVLLIIVGFAASF SLLSYAMETTPMGTAYAVWTGIGTAGGALIGILFYKEQKDAKRIFFIALILCSAVGLK ILS*" gene 1376855..1377172 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" promotor_-35 1377172..1377175 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1377191..1377210 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1377203 /Source="Nicolas_upshifts" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" CDS 1377243..1378145 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" /EC_number="3.5.1.10" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8226647, 24108189; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formyltetrahydrofolate hydrolase" /protein_id="NP_389194.2" /db_xref="EnsemblGenomes-Gn:BSU13110" /db_xref="EnsemblGenomes-Tr:CAB13168" /db_xref="GOA:O34990" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004810" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG13237" /db_xref="UniProtKB/Swiss-Prot:O34990" /translation="MKSYMTQRLDEYRDGNEDKGRLLVSCPDQPGIVSAVSAFLFEHG ANIIESNQYTTDPEGGRFFLRIEFDCAGIREKKSSLQAAFASVAEKFDMTWSLTLASE LKRVAIFVSKELHCLHELIWEWQTGNLMAEIAVVISNHEEARELVERLNIPFHYMKAN KDIRAEVEKKQLELLEQYDVDVIVLARYMQILTPDFVSAHPNRIINIHHSFLPAFIGA NPYKRAYERGVKLIGATSHYVTNDLDEGPIIEQDIERVDHRDNAEALKNIGRTIERSV LARAVKWHLEDRVIVHENKTIVFN*" gene 1377243..1378145 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" downshifts 1378136 /Source="Nicolas_upshifts" /id="D714" /incds=0 /nref=91 /ntot=226 /MaxReadThrough="3.55628" /MaxDrop="5.02155" /score="16.8011006" /energy="-13.1" /TU="U1057" /idTUdmin="U1056" /TUdmin=945 /isTUend="FALSE" promotor_-35 1378192..1378198 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1378204 /Source="Nicolas_upshifts" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" promotor_-10 1378212..1378231 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1378233..1378443 /gene="pswB" /locus_tag="BSU_misc_RNA_17" /product="T-box riboswitch specific of proline tRNA" /experiment="publication(s) with functional evidences, PMID:11917026, 12749771, 19932103, 21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11917026, 12749771, 19932103, 21233158; Product type n: RNA" /function="16.3: Control" gene 1378233..1378443 /gene="pswB" /locus_tag="BSU_misc_RNA_17" downshifts 1378401 /Source="Nicolas_upshifts" /id="D715" /incds=0 /nref=4 /ntot=52 /MaxReadThrough="6.91996" /MaxDrop="3.8361" /score="29.5878921" /energy="-17.6" /TU="U1057,U1058" /idTUdmin="U1056" /TUdmin=1210 /isTUend="FALSE" CDS 1378496..1379593 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" /EC_number="2.7.2.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21233158, 21784929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21233158, 21784929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389195.2" /db_xref="EnsemblGenomes-Gn:BSU13120" /db_xref="EnsemblGenomes-Tr:CAB13169" /db_xref="GOA:P39820" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10963" /db_xref="UniProtKB/Swiss-Prot:P39820" /translation="MKKQRIVVKIGSSSLTNSKGSIDEAKIREHVQAISVLKKAGHEM ILITSGAVAAGFSSLGYPSRPVTIKGKQAAAAVGQTLLMQQYMNQFKQYSLTPGQILL TRNDFSKRERYRNAYATIMELLERGVIPIINENDSTSVEELTFGDNDMLSALVSGLIH ADQLMILTDINGLYDANPNENPEAKRFDYLPEITPELLGYAGSAGSKVGTGGMKSKLL ATQTALSLGVKVFIGTGSGEQKLADILDGRGDGTYIGDKELSSVNNTRQWIQFHSPIS GEIIIDAGAEEAMIHNGSSLLPAGVVGVNGSFPKGAVVEVRGPGGVIGKGQTHYSSEE IMEAKGKRSDELDFEKTFEVIHRNDWVNVKD*" gene 1378496..1379593 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" promotor_-35 1378683..1378685 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1378687..1378691 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1378687 /Source="Nicolas_upshifts" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" CDS 1379605..1380852 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" /EC_number="1.2.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21784929, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21784929, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-glutamyl phosphate reductase" /protein_id="NP_389196.2" /db_xref="EnsemblGenomes-Gn:BSU13130" /db_xref="EnsemblGenomes-Tr:CAB13170" /db_xref="GOA:P39821" /db_xref="InterPro:IPR000965" /db_xref="InterPro:IPR012134" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR020593" /db_xref="SubtiList:BG10964" /db_xref="UniProtKB/Swiss-Prot:P39821" /translation="MSEVSVKAKLAKEAAAEMIMKTTAEKDEALSLIANGLRKELDFL LAENAKDIVNGKENGLTPDIIDRLSLDEKRIRDIADAVELLIDLADPIGDSLETIEKE NGLFIEKIRVPLGVVGMIYEARPNVTVDAATLCLKTGNAVVLRGSSSAIHSNKALVSV IYRALEQSALPIHAVQLIEDTSRETAKELFTLNDGLDVLIPRGGKKLIDLVVRESTVP VLETGAGNCHIFIDETAKPQMAEKVVVNAKTQRPSVCNAIESLLIHKAWARQHGKELL DQLENAGVEIRGDELVCELHPSSKQASKEDWETEFLAPVLSVKTVENVQEAVKHIQQY GTNHSEAILTENDKNAVYFQTAVDAAAVYHNASTRFTDGFEFGYGAEIGISTQKLHAR GPMGLPALTSTKYIIKGTGQIRE*" gene 1379605..1380852 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" downshifts 1380843 /Source="Nicolas_upshifts" /id="D716" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="4.1607" /MaxDrop="6.017" /score="11.118012" /energy="-11" /TU="U1058" /idTUdmin="U1059" /TUdmin=0 /isTUend="TRUE" promotor_-35 1380914..1380921 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1380936..1380955 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1380945 /Source="Nicolas_upshifts" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" CDS 1380978..1381403 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11418552, 17502599, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418552, 17502599, 21749987, 24184231; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin" /protein_id="NP_389197.1" /db_xref="EnsemblGenomes-Gn:BSU13140" /db_xref="EnsemblGenomes-Tr:CAB13171" /db_xref="GOA:O34762" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="SubtiList:BG13238" /db_xref="UniProtKB/Swiss-Prot:O34762" /translation="MSQPLFTATVSAVGGREGKVISSDRVLELDVAMPGTPRAKKLEK ATNPEQLFAAGYAACFDSALQLVARTERVKVETEVTANVSLLKDEADQGYKLGVTLQV KGEGVSASELEALVKKAHGVCPYSKATSGNIDVTLEVAE*" gene 1380978..1381403 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" downshifts 1381392 /Source="Nicolas_upshifts" /id="D717" /incds=0 /nref=57 /ntot=174 /MaxReadThrough="0.0429100000000009" /MaxDrop="3.90314" /score="30.9245751" /energy="-16.6" /TU="NA" /idTUdmin="U1060" /TUdmin="-1" /isTUend="TRUE" CDS complement(1381434..1381877) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11983871, 17502599, 18363800, 20094649, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11983871, 17502599, 18363800, 20094649, 21749987, 24184231; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator sensing organic peroxides" /protein_id="NP_389198.1" /db_xref="EnsemblGenomes-Gn:BSU13150" /db_xref="EnsemblGenomes-Tr:CAB13172" /db_xref="GOA:O34777" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1Z91" /db_xref="PDB:1Z9C" /db_xref="SubtiList:BG13239" /db_xref="UniProtKB/Swiss-Prot:O34777" /translation="MENKFDHMKLENQLCFLLYASSREMTKQYKPLLDKLNITYPQYL ALLLLWEHETLTVKKMGEQLYLDSGTLTPMLKRMEQQGLITRKRSEEDERSVLISLTE DGALLKEKAVDIPGTILGLSKQSGEDLKQLKSALYTLLETLHQKN*" gene complement(1381434..1381877) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" downshifts complement(1381468) /Source="Nicolas_upshifts" /id="D718" /incds=0 /nref=105 /ntot=232 /MaxReadThrough="-0.17111" /MaxDrop="4.73026" /score="34.7008532" /energy="-16.6" /TU="NA" /idTUdmin="U1061" /TUdmin=1 /isTUend="TRUE" promotor_-10 complement(1381904..1381923) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1381910) /Source="Nicolas_upshifts" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" promotor_-35 complement(1381938..1381941) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1381959..1381965 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1381979..1381997 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1381985 /Source="Nicolas_upshifts" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" CDS 1382020..1382430 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9696771, 11418552, 18084074" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696771, 11418552, 18084074; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="organic hydroperoxide resistance reductase B" /protein_id="NP_389199.1" /db_xref="EnsemblGenomes-Gn:BSU13160" /db_xref="EnsemblGenomes-Tr:CAB13173" /db_xref="GOA:P80242" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="PDB:2BJO" /db_xref="SubtiList:BG19021" /db_xref="UniProtKB/Swiss-Prot:P80242" /translation="MALFTAKVTARGGRAGHITSDDGVLDFDIVMPNAKKEGQTGTNP EQLFAAGYAACFGGALEHVAKEQNIEIDSEIEGQVSLMKDESDGGFKIGVTLVVNTKD LDREKAQELVNAAHEFCPYSKATRGNVDVKLELK*" gene 1382020..1382430 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" downshifts 1382408 /Source="Nicolas_upshifts" /id="D719" /incds=0 /nref=7 /ntot=145 /MaxReadThrough="8.17185" /MaxDrop="4.0663" /score="17.6512157" /energy="-12.1" /TU="U1062" /idTUdmin="U1062" /TUdmin="-855" /isTUend="FALSE" CDS 1382457..1382627 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097717.1" /db_xref="EnsemblGenomes-Gn:BSU13169" /db_xref="EnsemblGenomes-Tr:CAX52607" /db_xref="UniProtKB/Swiss-Prot:C0H400" /translation="MFFGVGHAGRAQIYDKTSEKRLKHAFKPKVTDEAGGWHGVCRAE LRVYAVLYLHRA*" gene 1382457..1382627 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" S_feature 1382628..1383305 /Source="Nicolas_S_feature" /locus_tag="new_1382628_1383305" /HighExp="Etha, Salt, M9-stat, Sw, B60, LPhT, B36, Heat, Gly, BC" /AntisenseName="guaD" /AntisenseCor="-5.7732597431508298E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S468" CDS complement(1382677..1383147) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" /EC_number="3.5.4.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11101664, 15180998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101664, 15180998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanine deaminase" /protein_id="NP_389200.1" /db_xref="EnsemblGenomes-Gn:BSU13170" /db_xref="EnsemblGenomes-Tr:CAB13174" /db_xref="GOA:O34598" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1TIY" /db_xref="PDB:1WKQ" /db_xref="SubtiList:BG13240" /db_xref="UniProtKB/Swiss-Prot:O34598" /translation="MNHETFLKRAVTLACEGVNAGIGGPFGAVIVKDGAIIAEGQNNV TTSNDPTAHAEVTAIRKACKVLGAYQLDDCILYTSCEPCPMCLGAIYWARPKAVFYAA EHTDAAEAGFDDSFIYKEIDKPAEERTIPFYQVTLTEHLSPFQAWRNFANKKEY*" gene complement(1382677..1383147) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" downshifts complement(1382701) /Source="Nicolas_upshifts" /id="D720" /incds=0 /nref=25 /ntot=112 /MaxReadThrough="0.698199999999999" /MaxDrop="4.30578" /score="-6.41557266" /energy="-13.5" /TU="NA" /idTUdmin="U1063" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1383169..1383188) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1383185) /Source="Nicolas_upshifts" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" S_feature complement(1383187..1383294) /Source="Nicolas_S_feature" /locus_tag="new_1383187_1383294_c" /HighExp="BMM, MG 10, MG 15, MG 5, MG t5, GM 25, B36, Gly, B60, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.044, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S469" promotor_-35 complement(1383204..1383207) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1383263 /Source="Nicolas_upshifts" /id="D721" /incds=0 /nref=9 /ntot=34 /MaxReadThrough="0.95942" /MaxDrop="5.95076" /score="15.2916843" /energy="-11.5" /TU="NA" /idTUdmin="U1062" /TUdmin=0 /isTUend="TRUE" CDS complement(1383320..1385608) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" /EC_number="2.1.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cobalamin-independent methionine synthase" /protein_id="NP_389201.2" /db_xref="EnsemblGenomes-Gn:BSU13180" /db_xref="EnsemblGenomes-Tr:CAB13175" /db_xref="GOA:P80877" /db_xref="InterPro:IPR002629" /db_xref="InterPro:IPR006276" /db_xref="InterPro:IPR013215" /db_xref="SubtiList:BG12616" /db_xref="UniProtKB/Swiss-Prot:P80877" /translation="MTTIKTSNLGFPRIGLNREWKKALEAYWKGSTDKDTFLKQIDEL FLSAVKTQIDQQIDVVPVSDFTQYDHVLDTAVSFNWIPKRFRHLTDATDTYFAIARGI KDAVSSEMTKWFNTNYHYIVPEYDESIEFRLTRNKQLEDYRRIKQEYGVETKPVIVGP YTFVTLAKGYEPSEAKAIQKRLVPLYVQLLKELEEEGVKWVQIDEPALVTASSEDVRG AKELFESITSELSSLNVLLQTYFDSVDAYEELISYPVQGIGLDFVHDKGRNLEQLKTH GFPTDKVLAAGVIDGRNIWKADLEERLDAVLDILSIAKVDELWIQPSSSLLHVPVAKH PDEHLEKDLLNGLSYAKEKLAELTALKEGLVSGKAAISEEIQQAKADIQALKQFATGA NSEQKKELEQLTDKDFKRPIPFEERLALQNESLGLPLLPTTTIGSFPQSAEVRSARQK WRKAEWSDEQYQNFINAETKRWIDIQEELELDVLVHGEFERTDMVEYFGEKLAGFAFT KYAWVQSYGSRCVRPPVIYGDVEFIEPMTVKDTVYAQSLTSKHVKGMLTGPVTILNWS FPRNDISRKEIAFQIGLALRKEVKALEDAGIQIIQVDEPALREGLPLKTRDWDEYLTW AAEAFRLTTSSVKNETQIHTHMCYSNFEDIVDTINDLDADVITIEHSRSHGGFLDYLK NHPYLKGLGLGVYDIHSPRVPSTEEMYNIIVDALAVCPTDRFWVNPDCGLKTRQQEET VAALKNMVEAAKQARAQQTQLV*" gene complement(1383320..1385608) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" downshifts complement(1383339) /Source="Nicolas_upshifts" /id="D722" /incds=0 /nref=212 /ntot=239 /MaxReadThrough="5.25958" /MaxDrop="7.50935" /score="29.3354648" /energy="-11.5" /TU="U1064,U1065" /idTUdmin="U1063" /TUdmin="-638" /isTUend="FALSE" S_feature complement(1385609..1385671) /Source="Nicolas_S_feature" /locus_tag="new_1385609_1385671_c" /HighExp="MG 15, MG 5, MG t5, BMM, T-1.40H, MG 25, MG 10, GM 25, Mal, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.044, 1, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S470" promotor_no_box complement(1385631..1385731) /Source="Nicolas_upshift_promotors" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1385671) /Source="Nicolas_upshifts" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" misc_RNA complement(1385736..1385891) /gene="mswB" /locus_tag="BSU_misc_RNA_18" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762, 22543867" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762, 22543867; Product type n : RNA" /function="16.3: Control" gene complement(1385736..1385891) /gene="mswB" /locus_tag="BSU_misc_RNA_18" downshifts complement(1385737) /Source="Nicolas_upshifts" /id="D723" /incds=0 /nref=55 /ntot=106 /MaxReadThrough="8.12248" /MaxDrop="6.4813" /score="24.0596293" /energy="-16.2" /TU="U1065,U1066" /idTUdmin="U1066" /TUdmin="-308" /isTUend="FALSE" promotor_-10 complement(1385924..1385943) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1385936) /Source="Nicolas_upshifts" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" S_feature complement(1385938..1386023) /Source="Nicolas_S_feature" /locus_tag="new_1385938_1386023_c" /HighExp="BT, BC, B36, M9-stat, T5.0H, S3, S6, T4.0H, S5, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S471" promotor_-35 complement(1385959..1385966) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1386024..1386983) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" /EC_number="3.4.21.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3087947, 14680823, 23569278" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3087947, 14680823, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="intracellular serine protease" /protein_id="NP_389202.1" /db_xref="EnsemblGenomes-Gn:BSU13190" /db_xref="EnsemblGenomes-Tr:CAB13176" /db_xref="GOA:P11018" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG10674" /db_xref="UniProtKB/Swiss-Prot:P11018" /translation="MNGEIRLIPYVTNEQIMDVNELPEGIKVIKAPEMWAKGVKGKNI KVAVLDTGCDTSHPDLKNQIIGGKNFTDDDGGKEDAISDYNGHGTHVAGTIAANDSNG GIAGVAPEASLLIVKVLGGENGSGQYEWIINGINYAVEQKVDIISMSLGGPSDVPELK EAVKNAVKNGVLVVCAAGNEGDGDERTEELSYPAAYNEVIAVGSVSVARELSEFSNAN KEIDLVAPGENILSTLPNKKYGKLTGTSMAAPHVSGALALIKSYEEESFQRKLSESEV FAQLIRRTLPLDIAKTLAGNGFLYLTAPDELAEKAEQSHLLTL*" gene complement(1386024..1386983) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" S_feature complement(1386984..1387035) /Source="Nicolas_S_feature" /locus_tag="new_1386984_1387035_c" /HighExp="BT, B36, BC, T5.0H, M9-stat, T0.30H, T3.30H, T3.0H, T4.0H, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S472" promotor_-10 complement(1387028..1387047) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1387040) /Source="Nicolas_upshifts" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" promotor_-35 complement(1387061..1387067) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1387152..1387155 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1387168 /Source="Nicolas_upshifts" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" promotor_-10 1387171..1387190 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1387206..1388039 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_389203.1" /db_xref="EnsemblGenomes-Gn:BSU13200" /db_xref="EnsemblGenomes-Tr:CAB13177" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12609" /db_xref="UniProtKB/Swiss-Prot:O34860" /translation="MKLNEKLYAFFSEHVEQMAEEWIETMEESDPNSLYALHNATVTE ELKEQDREFYRHLNYMYVLPEKQFLEEFQEWVIELTNDQKHLDTPVQYVIREFMRNRR LYTKYFEKFAEENESAFEPGEKQKWADLIVKVFDFTIYTFVDHAEMNAKQQLNAQREM ILELSSPVITLSKSTALLPLVGDIDTERAKFILENTLQACAKRRVEHLLIDLSGVVVV DTMVAHQIFKLIEALNLIGVRSTLSGIRPEIAQTAVQLGIDFSNITIKTNLAQALNYH Q*" gene 1387206..1388039 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" downshifts 1388015 /Source="Nicolas_upshifts" /id="D724" /incds=0 /nref=219 /ntot=254 /MaxReadThrough="3.01586" /MaxDrop="6.07238" /score="22.2655638" /energy="-12.1" /TU="NA" /idTUdmin="U1067" /TUdmin=0 /isTUend="TRUE" CDS complement(1388070..1388834) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, transmembrane T component" /protein_id="NP_389204.1" /db_xref="EnsemblGenomes-Gn:BSU13210" /db_xref="EnsemblGenomes-Tr:CAB13178" /db_xref="GOA:O34572" /db_xref="InterPro:IPR003339" /db_xref="SubtiList:BG13248" /db_xref="UniProtKB/Swiss-Prot:O34572" /translation="MKQPLHLINPTVKAAAVFCCVVMLSFIYNPYTPACFYIIIVAGV LLAAGIPLKKWLLFTIPFLILAFGCVWTAAVFGKVPTTPDNFLFQAGPISINSDNVSV GISLGFRILCFSALSMMFVFTTDPILFMLSLVQQCRLSPKLAYGVIAGFRFLPLLKDE VQLIQQAHKIRGGAAESGIINKISALKRYTIPLLASAIRKAERTALAMESKGFTGSRN RTYYRTLSVNRRDWVFFCLVLLLFAGSFLVSLCFAS*" gene complement(1388070..1388834) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" downshifts complement(1388091) /Source="Nicolas_upshifts" /id="D725" /incds=0 /nref=143 /ntot=164 /MaxReadThrough="0.824010000000001" /MaxDrop="6.67697" /score="34.7739353" /energy="-12.1" /TU="NA" /idTUdmin="U1069" /TUdmin=0 /isTUend="TRUE" CDS complement(1388809..1390452) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine ABC transporter (ATP-binding subunit)" /protein_id="NP_389205.2" /db_xref="EnsemblGenomes-Gn:BSU13220" /db_xref="EnsemblGenomes-Tr:CAB13179" /db_xref="GOA:O34362" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13249" /db_xref="UniProtKB/Swiss-Prot:O34362" /translation="MQAFDELLTVEQLSFSYEEDEKPVFQDISFELQKGECVLLLGPS GCGKSSLALCLNGLYPEACDGIQSGHVFLFQKPVTDAETSETITQHAGVVFQDPDQQF CMLTVEDEIAFGLENLQIPKEEMTEKINAVLEKLRITHLKEKMISTLSGGQKQKVALA CILAMEPELIILDEPTSLLDPFSAREFVHLMKDLQREKGFSLLVIEHQLDEWAPWIER TIVLDKSGKKALDGLTKNLFQHEAETLKKLGIAIPKVCHLQEKLSMPFTLSKEMLFKE PIPAGHVKKKKAPSGESVLEVSSLSFARGQQAIFKDISFSLREGSLTALVGPNGTGKS TLLSVLASLMKPQSGKILLYDQPLQKYKEKELRKRMGFVFQNPEHQFVTDTVYDELLF GQKANAETEKKAQHLLQRFGLAHLADHHPFAISQGQKRRLSVATMLMHDVKVLLLDEP TFGQDARTAAECMEMIQRIKAEGTAVLMITHDMELVSSYADSVLVLHDTGLAFDGSPA QLFSQETGLVQKAKLTLPLLYEWMAFQEEVRDEATVTSH*" gene complement(1388809..1390452) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" CDS complement(1390439..1391038) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 27447050, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 27447050, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, permease component" /protein_id="NP_389206.2" /db_xref="EnsemblGenomes-Gn:BSU13230" /db_xref="EnsemblGenomes-Tr:CAB13180" /db_xref="GOA:O34738" /db_xref="InterPro:IPR017195" /db_xref="PDB:5EDL" /db_xref="SubtiList:BG13250" /db_xref="UniProtKB/Swiss-Prot:O34738" /translation="MKSWKVKEIVIMSVISIVFAVVYLLFTHFGNVLAGMFGPIAYEP IYGIWFIVSVIAAYMIRKPGAALVSEIIAALVECLLGNPSGPMVIVIGIVQGLGAEAV FLATRWKAYSLPVLMLAGMGSSVASFIYDLFVSGYAAYSPGYLLIMLVIRLISGALLA GLLGKAVSDSLAYTGVLNGMALGKELKKKRKRASEHASL*" gene complement(1390439..1391038) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" CDS complement(1391040..1391642) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15451668, 16291685, 16356850, 20471400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15451668, 16291685, 16356850, 20471400; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiamine-binding protein (oxidation stress protein)" /protein_id="NP_389207.1" /db_xref="EnsemblGenomes-Gn:BSU13240" /db_xref="EnsemblGenomes-Tr:CAB13181" /db_xref="GOA:O34911" /db_xref="InterPro:IPR011522" /db_xref="InterPro:IPR015835" /db_xref="InterPro:IPR029756" /db_xref="PDB:1S7H" /db_xref="PDB:1S99" /db_xref="PDB:1SBR" /db_xref="SubtiList:BG13251" /db_xref="UniProtKB/Swiss-Prot:O34911" /translation="MEHICGTSRIAGFRFSLYPMTDDFISVIKSALKKTDTSKVWTKT DHISTVLRGSIDHVFDAAKAIYLHAANSEQHIVMNGTFSIGCPGDTQGDTYLSKGDKR VNEDAVRGLKAEAPCQFALYPMNEPDYMGLIMEAVDIAKAQGTFVQGVHYASELDGDA HDVFSTLEAVFRMAEQQTNHITMTVNLSANSPSRKNRKQG*" gene complement(1391040..1391642) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" downshifts complement(1391720) /Source="Nicolas_upshifts" /id="D726" /incds=0 /nref=28 /ntot=88 /MaxReadThrough="7.47395" /MaxDrop="5.73297" /score="19.7469386" /energy="-10.9" /TU="U1069" /idTUdmin="U1069" /TUdmin="-3629" /isTUend="FALSE" misc_RNA complement(1391739..1391851) /gene="tswB" /locus_tag="BSU_misc_RNA_19" /product="thiamine pyrophosphate riboswitch" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" gene complement(1391739..1391851) /gene="tswB" /locus_tag="BSU_misc_RNA_19" promotor_-35 1391852..1391855 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1391866..1391885) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1391871..1391890 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1391882 /Source="Nicolas_upshifts" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(1391887) /Source="Nicolas_upshifts" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" promotor_-35 complement(1391900..1391907) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1391953..1392639 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YkoH]" /protein_id="NP_389208.1" /db_xref="EnsemblGenomes-Gn:BSU13250" /db_xref="EnsemblGenomes-Tr:CAB13182" /db_xref="GOA:O34903" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13252" /db_xref="UniProtKB/Swiss-Prot:O34903" /translation="MEKGHILIVEDEEKIARVLQLELEYEGYSVTIKHNGTEGLDAAA EGGYSLVLLDVMLPGLSGLEVLRRLRKTDSQTPVILLTARDSIPDKVTGLDIGANDYV TKPFEIEELLARIRAALRQNGTKTEDIGTFLTYDDLRVNEKTREVRRGDKEVELTPRE FDLLVYMLKHPQQVLTREQILSSVWGFDYIGDTNVVDVYIRYIRKKLDYPYEKQLIHT IRGVGYAIKG*" gene 1391953..1392639 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" CDS 1392643..1394007 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YkoG]" /protein_id="NP_389209.1" /db_xref="EnsemblGenomes-Gn:BSU13260" /db_xref="EnsemblGenomes-Tr:CAB13183" /db_xref="GOA:O34638" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13253" /db_xref="UniProtKB/Swiss-Prot:O34638" /translation="MKLKTKIHLYTSISLLILLILVHTAVYLIFSSALTSKDAARLAD ETDNIAEALRAAETEGVALQDMLQAYLPANGMVRVVNGDQKAVMTITKEKAYKDFPLS FHSGETADVRKPDGKLFAEAAVPVIWTDGQVVSLQLVERLENTEESLFLLKIILIAAS AAVCIASFFAGSLLARRIINPIRRLMITMKDIQRDKEFKTISLEGQSNDELYQMGLTF NEMAMMLKEHYDKQQQFVQDASHELKTPLTIIESYSSLMKRWGAKKPEVLEESIEAIH SEAVHMKKLTNQLLALAKSHQGLEVDLKTIDLIKAARAVMQTLQSVYQRDILLETDKE SLLVKADEERIKQLLTILLDNAIKYSEKPIEMSAGTRNGRPFLSVRDEGIGIPEEHIP HLFERFYRADEARNRKTGGTGLGLSIAKQIADEHGIELSVKSKPGQGTAVTMQFSEQN GGGR*" gene 1392643..1394007 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" CDS 1394004..1394684 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295; Product type m : membranecomponent" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389210.1" /db_xref="EnsemblGenomes-Gn:BSU13270" /db_xref="EnsemblGenomes-Tr:CAB13184" /db_xref="GOA:O34551" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13254" /db_xref="UniProtKB/Swiss-Prot:O34551" /translation="MTKTIKTVSFAAAAILVVIICTFLIIRQTHENVLSKETVVKKVE ASYEGKVTKATQSKDKKTYDITLENPKGTYFVKADAISADILSMNRVKAVNPSAMTEK EAEHLALERVPGTVKKQTRQSQVATYTIQKEDGKTYEVKVDMQAKTVLSADQISSKDQ QKTPITKKEAKTIAERKTGGTADDADLEESEGTLIFEVDVDLPDNKEATVKINAYTGK VANIVYED*" gene 1394004..1394684 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" promotor_-35 1394713..1394718 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1394734..1394752 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1394737 /Source="Nicolas_upshifts" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" CDS 1394776..1395288 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17209068; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389211.1" /db_xref="EnsemblGenomes-Gn:BSU13280" /db_xref="EnsemblGenomes-Tr:CAB13185" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13255" /db_xref="UniProtKB/Swiss-Prot:O35012" /translation="MLKKKWMVGLLAGCLAAGGFSYNAFATENNENRQASSKTDALTE QEAEAIAKTVVDGTVEDIDRDLYNGKEVYEVEIEKEGEDYDVYVDIHTKQALNDPLKE KAEQVAITKEEAEEIALKQTGGTVTESKLDEDDGAYIYEMEIQTKQGTETEFEISAKD GRIIKQEIDD*" gene 1394776..1395288 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" downshifts 1395274 /Source="Nicolas_upshifts" /id="D727" /incds=0 /nref=52 /ntot=228 /MaxReadThrough="3.74302" /MaxDrop="6.03059" /score="28.1760649" /energy="-13.7" /TU="U1070" /idTUdmin="U1070" /TUdmin="-198" /isTUend="FALSE" promotor_-35 1395319..1395325 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1395339..1395350 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1395340 /Source="Nicolas_upshifts" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" CDS 1395371..1395508 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389212.1" /db_xref="EnsemblGenomes-Gn:BSU13290" /db_xref="EnsemblGenomes-Tr:CAB13186" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG13332" /db_xref="UniProtKB/Swiss-Prot:O34405" /translation="MEKKEEQYINQAEYVPHPTKEGEYALFLHETYHLLSEDDETQTT E*" gene 1395371..1395508 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" downshifts 1395481 /Source="Nicolas_upshifts" /id="D728" /incds=0 /nref=7 /ntot=31 /MaxReadThrough="1.81189" /MaxDrop="3.56977" /score="-4.52149284" /energy="-5.9" /TU="NA" /idTUdmin="U1070" /TUdmin=9 /isTUend="TRUE" promotor_-35 1395567..1395574 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1395588..1395607 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1395590..1395909 /Source="Nicolas_S_feature" /locus_tag="new_1395590_1395909" /HighExp="LBGstat, LBGtran, M40t45, MG 25, Mt0, Salt, MG 45, LPhT, BMM, MG t5" /AntisenseName="ykzO" /AntisenseCor="-0.16301119751811899" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S473" upshifts 1395590 /Source="Nicolas_upshifts" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" misc_RNA 1395622..1395775 /gene="swmG" /locus_tag="BSU_misc_RNA_68" /product="magnesium riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 17803910, 21315082, 28455443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 17803910, 21315082, 28455443; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" gene 1395622..1395775 /gene="swmG" /locus_tag="BSU_misc_RNA_68" promotor_-35 1395887..1395896 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1395909..1395928 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1395911..1396012 /Source="Nicolas_S_feature" /locus_tag="new_1395911_1396012" /HighExp="LBGstat, LBGtran, M40t45, Mt0, LPhT, Paraq, MG t5, MG 25, MG 60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99773400000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.876, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S474" upshifts 1395911 /Source="Nicolas_upshifts" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" CDS 1396013..1397368 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 22970223, 24415722, 24968120, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 22970223, 24415722, 24968120, 25182490; Product type t : transporter" /codon_start=1 /transl_table=11 /product="magnesium transporter" /protein_id="NP_389213.1" /db_xref="EnsemblGenomes-Gn:BSU13300" /db_xref="EnsemblGenomes-Tr:CAB13187" /db_xref="GOA:O34442" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006667" /db_xref="InterPro:IPR006668" /db_xref="InterPro:IPR006669" /db_xref="InterPro:IPR036739" /db_xref="SubtiList:BG13256" /db_xref="UniProtKB/Swiss-Prot:O34442" /translation="MVQNMTYDELILRIIILLRDGKIRDFRSVIDELQPYDMAFIFKE MPEKHRARYLSYLTVDDITDMIGELEREFQLVVLNKVGKTKATLAMNKMDNDDLAQLL EEMDEELKEQLLSSMEASESKAVQLLMNYPADSAGRMMTNRYVWIPQHYTVKDAVVKL KSFAEIAESINYLYVINESKQLVGVLSYRDLILGEPEEKVQDLMFTRVISADALQDQE EVARLIERYDFLAIPVVEENNVLVGIVTVDDIIDVVIREADEDYEKFAASGKDITFDT KAYVAAYRRLPWLILLLFIGLISGSIISYFEDALKQVVALAFFMPMVSGMTGNTGTQS LAVVIRGLSKEEMNKKTIVRLIFREFRTSIFIGAVCSVLIAIVSIIWQGNALLGFVVA SSLFLTLIIGTMSGTIIPIILHKLKVDPAIASGPLITTLNDILSLLIYFGIATAFIHS L*" gene 1396013..1397368 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" downshifts 1397359 /Source="Nicolas_upshifts" /id="D729" /incds=0 /nref=160 /ntot=239 /MaxReadThrough="1.02063" /MaxDrop="7.38933" /score="-4.14569718" /energy="-8.9" /TU="NA" /idTUdmin="U1072" /TUdmin="-4" /isTUend="TRUE" CDS complement(1397411..1397743) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen sensing transcriptional regulator" /protein_id="NP_389214.1" /db_xref="EnsemblGenomes-Gn:BSU13310" /db_xref="EnsemblGenomes-Tr:CAB13188" /db_xref="GOA:Q45666" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG11805" /db_xref="UniProtKB/Swiss-Prot:Q45666" /translation="MTTEDHSYKDKKVISIGIVSELTGLSVRQIRYYEERKLIYPQRS SRGTRKYSFADVERLMDIANKREDGVQTAEILKDMRKKEQMLKNDPQVRKKMLEGQLN AHFRYKNR*" gene complement(1397411..1397743) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" promotor_-10 complement(1397759..1397778) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1397769) /Source="Nicolas_upshifts" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" S_feature complement(1397771..1398159) /Source="Nicolas_S_feature" /locus_tag="new_1397771_1398159_c" /HighExp="M9-stat, BC, LoTm, T1.30H, T0.30H, T2.0H, S8, C30, T4.0H, T2.30H" /AntisenseName="ykzB" /AntisenseCor="-3.3870578787867499E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.92" /TUlongSig="NA" /TUlongPSig="NA" /label="S475" promotor_-35 complement(1397794..1397799) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 1397831..1397931 /Source="Nicolas_upshift_promotors" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1397891 /Source="Nicolas_upshifts" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" CDS 1397938..1398093 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389215.1" /db_xref="EnsemblGenomes-Gn:BSU13320" /db_xref="EnsemblGenomes-Tr:CAB13189" /db_xref="SubtiList:BG13330" /db_xref="UniProtKB/Swiss-Prot:O34923" /translation="MEEEKAVSLAKEIIELDIKRDEMLETFMQLAGEQAFQLLRSVQN GQYRKSS*" gene 1397938..1398093 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" promotor_-35 1398102..1398109 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1398116..1398133 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1398133 /Source="Nicolas_upshifts" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" promotor_-10 complement(1398144..1398163) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1398159) /Source="Nicolas_upshifts" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" promotor_-35 complement(1398177..1398183) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1398181..1398363 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389216.1" /db_xref="EnsemblGenomes-Gn:BSU13330" /db_xref="EnsemblGenomes-Tr:CAB13190" /db_xref="SubtiList:BG13257" /db_xref="UniProtKB/Swiss-Prot:O34763" /translation="MSNLLKSALEKERRHYSEKLYQIGVYNKEVMNKMTISELRKEYA YFFRSITNHKNYPYTR*" gene 1398181..1398363 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" downshifts 1398331 /Source="Nicolas_upshifts" /id="D730" /incds=0 /nref=2 /ntot=8 /MaxReadThrough="3.83398" /MaxDrop="4.6651" /score="19.6832496" /energy="-11.2" /TU="U1076" /idTUdmin="U1075" /TUdmin=0 /isTUend="TRUE" promotor_-35 1398388..1398396 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1398407..1398425 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1398413..1398495 /Source="Nicolas_S_feature" /locus_tag="new_1398413_1398495" /HighExp="T3.0H, M9-stat, T1.30H, T2.30H, Lbstat, T3.30H, Lbtran, S2, T4.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, Sig-" /TUshortPSig="0.996, 0.00699" /TUlongSig="NA" /TUlongPSig="NA" /label="S476" upshifts 1398413 /Source="Nicolas_upshifts" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" CDS 1398496..1398960 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_389217.1" /db_xref="EnsemblGenomes-Gn:BSU13340" /db_xref="EnsemblGenomes-Tr:CAB13191" /db_xref="GOA:O34949" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13258" /db_xref="UniProtKB/Swiss-Prot:O34949" /translation="MMRLSFNEEEVERAMNLYRVFARAFKSVSEHSIRDSKEHGFNPT EFAVLELLYTRGPQKLQQIGSRLLLVSGNVTYVIDKLERNGFLVREQDPKDKRSVYAH LTDKGNEYLDKIYPIHALRIARAFSGLSPDEQDQLIVLLKKAGIHSQHLLFR*" gene 1398496..1398960 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" downshifts 1398945 /Source="Nicolas_upshifts" /id="D731" /incds=0 /nref=70 /ntot=210 /MaxReadThrough="2.86787" /MaxDrop="5.38705" /score="24.8730632" /energy="-9.8" /TU="U1078" /idTUdmin="U1078" /TUdmin="-112" /isTUend="FALSE" CDS complement(1398975..1400096) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389218.2" /db_xref="EnsemblGenomes-Gn:BSU13350" /db_xref="EnsemblGenomes-Tr:CAB13192" /db_xref="GOA:C0SPB9" /db_xref="InterPro:IPR009695" /db_xref="SubtiList:BG13259" /db_xref="UniProtKB/Swiss-Prot:C0SPB9" /translation="MKNILIFPFLSISTGHHHVADALQAELESQGLAAEKIDIFSHSY RRLEKLSSVAYLKWIQYFPKTYSGIYRLLACGEFQHDKRYFMYEWLFTQQMRHILQEK QPDIAFCTHALPSYLLNRLKPEYPNLTVVNVYTDFFVNQLWGRKNIDYHFVPSTEVKK QLISEGIDQNNIYLTGIPVHQNFEMESADTLQHHPPYTIIITGGSMGVGGILKWVQEL SPGGKILYKILCGRNEKLYSYVKSLHHPLIEAIPYLHSKAEMNRLYEQATGIMTKPGG VTISECLQKRLPVFIYHALPGQEEMNLNLLHERKLVTDMRNWDMQKAEEYIAAFFQSN EQMKEYKKHVNGYLGEMSDRKIKDVLKRIIWKQKNTLLK*" gene complement(1398975..1400096) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" promotor_-35 1399384..1399392 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1399406..1399425 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1399409..1400187 /Source="Nicolas_S_feature" /locus_tag="new_1399409_1400187" /HighExp="S6, S8, S7, S5, BT, B36, S4, S3, Pyr, G/S" /AntisenseName="ykoN" /AntisenseCor="0.84084970563549499" /AntisenseRegPval="-72.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S477" upshifts 1399409 /Source="Nicolas_upshifts" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" promotor_-10 complement(1400125..1400136) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1400145) /Source="Nicolas_upshifts" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1400151..1400157) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1400188..1400739 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389219.2" /db_xref="EnsemblGenomes-Gn:BSU13360" /db_xref="EnsemblGenomes-Tr:CAB13193" /db_xref="SubtiList:BG13260" /db_xref="UniProtKB/Swiss-Prot:O34495" /translation="MKTCFLSIWRVVDPIYFFFSRLSLIDNDQKSVFRVRLTKYKGHH VVLSDGTHIRKNDVLVKIHLHNIKLIRELQSIESAVRKGIIIYQKVYQSMPLLLDYIN NHKKSEKIKGIIGITMLDKGVERLGFDVITPVNPFYRCFKKVSHVPILYLTSKPVSLR HLPNSSYLFISKEKLQKTYQKKD*" gene 1400188..1400739 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" downshifts 1400707 /Source="Nicolas_upshifts" /id="D732" /incds=0 /nref=4 /ntot=25 /MaxReadThrough="3.31887" /MaxDrop="3.7149" /score="-2.92393792" /energy="-7" /TU="U1079" /idTUdmin="U1079" /TUdmin="-242" /isTUend="FALSE" CDS complement(1400767..1401579) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metallophosphoesterase" /protein_id="NP_389220.1" /db_xref="EnsemblGenomes-Gn:BSU13370" /db_xref="EnsemblGenomes-Tr:CAB13194" /db_xref="GOA:O35040" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13261" /db_xref="UniProtKB/Swiss-Prot:O35040" /translation="MFTILLSLAILVFVPFLYKANRNTKDVKVNTISIDQKDGLPARK KLNILHLSDLHLENISVSPEELYHLTKDQPVDIIALTGDFLDRKRNIPKLAGYLNALQ KLKPAYGMYAVFGNHDYVLKEEDFQRLKRVLEENGCITLQNEHVRIETAAGPVNIIGI DDYSTNRSNITGSYQSLENGYHLVLTHDPNIILDMKDVHYDYLLSGHFHGGQIHWPKP YHLVKMGKLVRMNMIKGLHYHHDKPFYISEGLGQTGVNIRVGSRPEVTFHQI*" gene complement(1400767..1401579) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" promotor_-10 complement(1401539..1401558) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1401553) /Source="Nicolas_upshifts" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1401572..1401577) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1401680..1401686 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1401697..1401771 /Source="Nicolas_S_feature" /locus_tag="new_1401697_1401771" /HighExp="S5, S6, S7, S4, S8, T5.0H, ferm, nit, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S478" upshifts 1401697 /Source="Nicolas_upshifts" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" promotor_-10 1401700..1401711 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1401772..1403466 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389221.1" /db_xref="EnsemblGenomes-Gn:BSU13380" /db_xref="EnsemblGenomes-Tr:CAB13195" /db_xref="GOA:O34830" /db_xref="SubtiList:BG13262" /db_xref="UniProtKB/Swiss-Prot:O34830" /translation="MLRLMRQQKKETYYLWIALFLLLLYVSPLFILKEDAHIRVHDNL DSNIAWYKVLADSGEIVGKVDAAIPQIINGLPRDAFGTEWSGIVWLHAFFSSMTAYAI SQTVTRVVAFFGMYVLLKKHIIPEPKAAFIRIGVSLAFALTPFWPSGMLSTLGYPLAL WAFLNIRKGDISWREWLTLGLLPLYSSFVLGFFFFLAGMACFWLYDAITKRRWNLMFL GSIAFMTSIYLFVEYRLVYSMLFEHAPMHRIEFISSRHDVWHSLRLSIKNFVYGHNHV MTVHTVVILPILMVVFAALLFKRNRTKPENVYLFLCVLNYGLSLWYAFWFNKIWAVPK QKFAFLAEFNFARFHFLRPLVIYVSFALALYLIWRMGKGWKWLVYAAVAAQLMVLAPF NEEYTYGVHYNAPTFREFYASEQFKEIKEYIGRPQDSYRVASIGLHPSIAQYNGFYTL DTYNNLYPLSYKYEFRKIIEKELEKNSRLKQYFDEWGSRCYLFVDELGKRYDFKKNSK KTINNLQLNTDVFKKMGGRYIFSSVPIMNAEQNHLALVKTFDHKDSAWRIYLYETR*" gene 1401772..1403466 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" CDS 1403479..1404492 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" /EC_number="2.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389222.1" /db_xref="EnsemblGenomes-Gn:BSU13390" /db_xref="EnsemblGenomes-Tr:CAB13196" /db_xref="GOA:O34755" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13263" /db_xref="UniProtKB/Swiss-Prot:O34755" /translation="MKQSQPVLTIVVPCFNEEEVFQETSHQLTEVVDDLIEEKLIAED SKILFVDDGSKDRTWALIAMESIRNKKVTGLKLACNVGHQKALLAGLHKAKNRSDCVI SIDADLQDDISVIRDFMLKYHEGCEIVYGVRRSRKTDTFFKRTTALGFYRLMNKLGIK LIYNHADFRLMNKRSLEELERYPEANLFLRGIVPMIGFKSAEVLYDRKERFAGKTKYP LKKMLSFAFNGITSFSVAPIRFFTLLGFVLFFLSAVAGIGAFIQKLLGHTNAGWASLI ISIWFLGGLQLMGIGIIGEYIGTIFSEVKRRPKYAIDIDLYNEQLSPLQRQEKERLEK KYS*" gene 1403479..1404492 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" downshifts 1404477 /Source="Nicolas_upshifts" /id="D733" /incds=0 /nref=13 /ntot=35 /MaxReadThrough="0.53349" /MaxDrop="4.80671" /score="19.4012674" /energy="-13.7" /TU="NA" /idTUdmin="U1082" /TUdmin=8 /isTUend="TRUE" CDS complement(1404518..1406353) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" /EC_number="6.5.1.1" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12215643, 16497325, 17293412, 23691176, 25355514, 26826709" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12215643, 16497325, 17293412, 23691176, 25355514, 26826709; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit; 5'-2-deoxyribose-5-phosphate (dRP) lyase" /protein_id="NP_389223.1" /db_xref="EnsemblGenomes-Gn:BSU13400" /db_xref="EnsemblGenomes-Tr:CAB13197" /db_xref="GOA:O34398" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR014143" /db_xref="InterPro:IPR014145" /db_xref="InterPro:IPR014146" /db_xref="InterPro:IPR033652" /db_xref="SubtiList:BG13264" /db_xref="UniProtKB/Swiss-Prot:O34398" /translation="MAFTMQPVLTSSPPIGAEWRYEVKYDGYRCILRIHSSGVTLTSR NGVELSSTFPEITQFAKTAFQHLEKELPLTLDGEIVCLVNPCRADFEHLQVRGRLKRP DKIQESANARPCCFLAFDLLERSGEDVTLLSYLDRKKSLRELISAAKLPASPDPYAKE TIQSIPCYDHFDQLWEMVIKYDGEGIVAKKTNSKWLEKKRSSDWLKYKNFKQAYVCIT GFNPNNGFLTVSVLKNGIMTPIASVSHGMRDEEKSAIREIMEQHGHQTPSGEFTLEPS ICAAVQYLTILQGTLREVSFIGFEFQMDWTECTYAQVIRHSKPVHPKLQFTSLDKIIF EKNKKTKEDFIQYMIEVSDYLLPFLKNRAVTVIRYPHGSRSESFFQKNKPDYAPDFVQ SFYDGSHEHIVCEDMSTLLWLCNQLALEFHVPFQTIKSRRPAEIVIDLDPPSRDDFLM AVQAANELKRLLDSFGITSYPKLSGNKGIQLYIPLSPEAFTYEETRQFTQLIAEYCTN AFPELFTTERLIKNRHCKLYLDYLQHAEGKTIICPYSTRGNELGTVAAPLYWHEVQSS LTPALFTIDTVIDRIKKQGCPFFDFYRNPQDEPLSAILHQLKKKS*" gene complement(1404518..1406353) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" downshifts complement(1404567) /Source="Nicolas_upshifts" /id="D734" /incds=0 /nref=10 /ntot=54 /MaxReadThrough="0.67916" /MaxDrop="5.08051" /score="-8.48510187" /energy="-13.7" /TU="NA" /idTUdmin="U1083" /TUdmin=0 /isTUend="TRUE" CDS complement(1406357..1407292) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11095673, 12215643, 16497325, 16780573, 23691176, 25355514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11095673, 12215643, 16497325, 16780573, 23691176, 25355514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit Ku; AP/deoxyribose 5'-phosphate (5'-dRP)-lyase" /protein_id="NP_389224.1" /db_xref="EnsemblGenomes-Gn:BSU13410" /db_xref="EnsemblGenomes-Tr:CAB13198" /db_xref="GOA:O34859" /db_xref="InterPro:IPR006164" /db_xref="InterPro:IPR009187" /db_xref="InterPro:IPR016194" /db_xref="SubtiList:BG13265" /db_xref="UniProtKB/Swiss-Prot:O34859" /translation="MNRTPSLHTKEKKGFIDMHTMWKGSISFGLVNIPIKLYAATEDK DIKLRSLHKEDHAPIKYEKVCTNCEKTLSPDEIVKGYEYVKGKYVVLTDEDLKSLKQE HEEKAVEIVDFVQLQEIDPIYFNRSYFVGPGDNGTKAYTLLREALRSTGKIGIANMTI RSKQQLAILRVYENCIVMESIHYPDEVRSAAQVPGVPDQSNVNDKELQTAITLIDELT AKFEPEKYEDTYRQALLQRVNDKLENKETAVTPDKAPPREDVIDLVSALQASIDRTRR PNRETPAAAPAQAAEPKGAGDKKQKTTRKKASGTS*" gene complement(1406357..1407292) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" promotor_-10 complement(1407263..1407274) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1407273) /Source="Nicolas_upshifts" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" promotor_-35 complement(1407289..1407295) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1407329..1409731) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11728710, 17010156, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11728710, 17010156, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="YP_054577.2" /db_xref="EnsemblGenomes-Gn:BSU13420" /db_xref="EnsemblGenomes-Tr:CAB13199" /db_xref="GOA:O34311" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR005330" /db_xref="InterPro:IPR029787" /db_xref="InterPro:IPR035919" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG13266" /db_xref="UniProtKB/Swiss-Prot:O34311" /translation="MEIHVTYNTTLICLSILIACTASYISLELSRKVTINTGLKSKIW LIGGSLIMGFGIWSMHFVGMMAVHMEMPMEYEFMPLMAAIGASVSGSFVSLYFVSRHI LTYYRLLTGSVVLGASIASMHYIGMSAISRVMIIYEPILFTVSIIIAIAASFVSLKIF FDLAVKKHSEHLIFYKGVSSIVMGIGISGMHYTGMLAATFHKDMAPPGSHMEVQTFHW SIFVTLIIFCIQTLLLFSSHADRKFIKQSERIKDNEQRFQSLIVHNIDAIFILSLEGD IISSNHAGEEMISKFGFSMHDWRNYTSLKVKRLFEQVKKDKQAMNSDSDLITEKGQFH LNITLIPVEVNQELDSIYVICKDMTKQYKAEKEIHRMAHYDSLTDLPNRRHAISHLTK VLNREHSLHYNTVVFFLDLNRFKVINDALGHNVGDQLLQFAAKRLSSVVPDNGFIARL GGDEFIIILTDANTGTGEADVLARKIIQKFKKPFKIQDHTLVTSVSIGIAISPKDGTD GLELMKKADMAMYAAKERNKSKYRYYSFSIGNKETVKLNQEMVLREAIENDRFVLHYQ PQFSVKKQKMTGAEALIRLVTPDGQLRPPGEFIGVAEETGLIIDIGKWIIDEACKQAR IWHDKGYDLSVAINISARQFQSKDLIPLIKDTLNKYQLPPQLLEVEVTESMTMDNLNH SKKVLSSLTELGIRISIDDFGTGHSSLSYLKDFPIHRLKIDKSFIDDIQTHPKSEQIT GAIIAMGHQLSLQVIAEGVENAAQKQLLFEKGCDHLQGFFFSRPIPPEQFEQFIIEQP SQ*" gene complement(1407329..1409731) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" downshifts complement(1407361) /Source="Nicolas_upshifts" /id="D735" /incds=0 /nref=13 /ntot=101 /MaxReadThrough="1.93589" /MaxDrop="3.26543" /score="6.55794882" /energy="-9" /TU="NA" /idTUdmin="U1084" /TUdmin=0 /isTUend="TRUE" S_feature complement(1409579..1409781) /Source="Nicolas_S_feature" /locus_tag="new_1409579_1409781_c" /HighExp="Cold, GM 25, GM 10, GM 45, GM 15, GM-0.2, GM-0.1, GM 5, GM 90, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S479" promotor_-10 complement(1409770..1409788) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1409781) /Source="Nicolas_upshifts" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" promotor_-35 complement(1409802..1409809) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1409848..1409855 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1409869..1409888 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1409881 /Source="Nicolas_upshifts" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" CDS 1409912..1410577 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23687963; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389226.1" /db_xref="EnsemblGenomes-Gn:BSU13430" /db_xref="EnsemblGenomes-Tr:CAB13200" /db_xref="GOA:O34908" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13267" /db_xref="UniProtKB/Swiss-Prot:O34908" /translation="MIHKHETRELVAIEELVMSWIEAFKSLSYFGIFLALSIEFIPAE VVLPLAGYWVSKGDMTLAGVVLAGSLGGVAGPLTLYWIGRYGGRPFLERFGKYLFIKP EALDKSDNFFKKHGGFVAFSGRFLPGIRTLISIPCGIAKMNVWVFSLYTFIAMLPITF VYVYLGVKLGENWKAVGSILDQYMLPIGIAILALFLLYLLMKKRKKRTHSEQLSVFLK NKR*" gene 1409912..1410577 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" promotor_-10 complement(1410446..1410465) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1410463) /Source="Nicolas_upshifts" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1410479..1410488) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1410572..1410579 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1410594..1410613 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1410607 /Source="Nicolas_upshifts" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" misc_RNA 1410633..1410766 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" /product="manganese ion riboswitch" /experiment="publication(s) with functional evidences, PMID:25794618, 25794619" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25794618, 25794619; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" gene 1410633..1410766 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" CDS 1410654..1411628 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15096624, 15849754, 16850406, 25794618, 25794619; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative manganese-related ion transporter" /protein_id="NP_389227.1" /db_xref="EnsemblGenomes-Gn:BSU13440" /db_xref="EnsemblGenomes-Tr:CAB13201" /db_xref="GOA:O34997" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13268" /db_xref="UniProtKB/Swiss-Prot:O34997" /translation="MYSGNKVVISWIVSIGFVGMPEFMSSKTFALCRQRSFLHGPAGI RSDEEKENNFFGRVSFMDAALLLEYGWVLLVLIGLEGILAADNALVMAVMVKHLPEEK RKKALFYGLAGAFVLRFGSLFAISFLVNVWQVQAIGAIYLLYISASHLLKRYVFKKED THKETKQSGFWPTVLKVELADIAFAVDSILAAVALAVTLPGTSLPKIGGLDGGQFLVI LAGGIIGLVIMRFAASMFVKLLKERPSLETAAFVIVGWVGVKLALYTLAHRDIAVVSE HFIHSGTWKLIFWGVLAAIAVCGWFMSGGKKQPEGAQNEQKNSTRERA*" gene 1410654..1411628 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" downshifts 1410717 /Source="Nicolas_upshifts" /id="D736" /incds=1 /nref=38 /ntot=211 /MaxReadThrough="5.00041" /MaxDrop="4.46498" /score="15.8563987" /energy="-15" /TU="U1085,U1087" /idTUdmin="U1085" /TUdmin="-902" /isTUend="FALSE" downshifts 1411616 /Source="Nicolas_upshifts" /id="D737" /incds=0 /nref=16 /ntot=175 /MaxReadThrough="2.59801" /MaxDrop="4.20782" /score="24.4740487" /energy="-13.7" /TU="NA" /idTUdmin="U1085" /TUdmin="-3" /isTUend="TRUE" promotor_-35 1411738..1411746 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1411760..1411768 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1411770 /Source="Nicolas_upshifts" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" S_feature 1411773..1411859 /Source="Nicolas_S_feature" /locus_tag="new_1411773_1411859" /HighExp="M9-stat, T1.30H, T1.0H, T0.30H, T2.0H, T2.30H, HiTm, M0t90, T3.0H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29969800000000002" /TUshortSig="SigI" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S480" promotor_-35 1411832..1411839 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1411853..1411872 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1411861 /Source="Nicolas_upshifts" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" CDS 1411892..1412647 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma factor (heat stress responsive)" /protein_id="NP_389228.1" /db_xref="EnsemblGenomes-Gn:BSU13450" /db_xref="EnsemblGenomes-Tr:CAB13218" /db_xref="GOA:O31654" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014244" /db_xref="InterPro:IPR014284" /db_xref="SubtiList:BG13269" /db_xref="UniProtKB/Swiss-Prot:O31654" /translation="MKPVLSLLFKLGKKKQTLEKAVESIQKGNKDLQNELIQQYKPFI AKTVSSVCKRYIDEKDDEFSIGLIAFNEAIEKYSPEKGNSLLAFAELIIKRKVIDYIR KEARSAQNINIDLQEGDDQESSQSLIEAELSIDEYRRQIEQEQRREEILYFQKQLKDY GLSFKELLENSPKHTDARQNAIKVAMTLVEHEELAAILYTKKQLPVKQLEQLVSVSRK TIERNRKYIIAMCIIITGDYIYLKDYLKGVLHS*" gene 1411892..1412647 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" CDS 1412644..1413789 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17185538, 23199363, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17185538, 23199363, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="sigmaI modulating factor" /protein_id="NP_389229.1" /db_xref="EnsemblGenomes-Gn:BSU13460" /db_xref="EnsemblGenomes-Tr:CAB13219" /db_xref="GOA:O31655" /db_xref="InterPro:IPR024449" /db_xref="SubtiList:BG13272" /db_xref="UniProtKB/Swiss-Prot:O31655" /translation="MRRGIIVEKNKKFVTLLTPDGQFLKAKNDRHSYEIGEEIMLPSE TRMGRRASFFDFFKLRPFKMGIFTMTAIMLFIFIVLPVFSNNKAYAYMTIDINPSVEM ALNSDYEVIELTPLNDEGQKVVNDIDDWEKTDFKKVIDDIITDCSEHGYVKKSKEILI STVYENTEDNTYKKAVKKQLNDVTEKYKTTYRMESLESDMQTREKAKKEGVSTGSYIK SNEKNDNKDIKDDSSKPSGEEDQKSDENEDENTDQTDTQDSKQGDNEQLNDADSGDQK EEKADDQIDDSDKDKKIKESDENTNTEKDGDHEQTPIQDPQDKGNENNGADKGQSQYH RDWNNGEQGKNRSSSRRDNASDRRNPNGYSSDNHSAKNEDSPSAPGE*" gene 1412644..1413789 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" S_feature 1413790..1414949 /Source="Nicolas_S_feature" /locus_tag="new_1413790_1414949" /HighExp="HiTm, G135, G180, C30, G150, Cold, S8, MG 25, H2O2, Lbstat" /AntisenseName="ykrK" /AntisenseCor="0.122248209149143" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigI" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S481" CDS complement(1413800..1413994) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:3009397, 3112127, 3121585, 9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009397, 3112127, 3121585, 9852018; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_389230.1" /db_xref="EnsemblGenomes-Gn:BSU13470" /db_xref="EnsemblGenomes-Tr:CAB13220" /db_xref="GOA:P04833" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10788" /db_xref="UniProtKB/Swiss-Prot:P04833" /translation="MASRNKLVVPGVEQALDQFKLEVAQEFGVNLGSDTVARANGSVG GEMTKRLVQQAQSQLNGTTK*" gene complement(1413800..1413994) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" downshifts complement(1413807) /Source="Nicolas_upshifts" /id="D738" /incds=0 /nref=24 /ntot=36 /MaxReadThrough="1.67859" /MaxDrop="4.68215" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1090" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1414037..1414048) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1414047) /Source="Nicolas_upshifts" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" promotor_-35 complement(1414063..1414069) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1414125..1414826) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22447908, 23042994" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22447908, 23042994; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of quality control" /protein_id="NP_389231.1" /db_xref="EnsemblGenomes-Gn:BSU13480" /db_xref="EnsemblGenomes-Tr:CAB13221" /db_xref="InterPro:IPR014975" /db_xref="SubtiList:BG13273" /db_xref="UniProtKB/Swiss-Prot:O31656" /translation="MNIFKLSRTDMVRLLYSLKGQGEHSPLDILVQSANMSAEKAANH LEIPEFLTRYERKKQKKEYGLSTNEIVELGNLCELTSLKSTAIQNWVKRDIKDLIGHP ELGKKYSIEQAVILLIVRDLKSIYDFEHIRAILKVAFNTISDRSDDVISPIAYYESCA YVLDAIHHQDTPSMKESNLQEIAEQETERLRHRFEELNDSQWLKIRQIIAITVLSILT FHIQATAHKMTADIL*" gene complement(1414125..1414826) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" downshifts complement(1414159) /Source="Nicolas_upshifts" /id="D739" /incds=0 /nref=174 /ntot=231 /MaxReadThrough="2.96889" /MaxDrop="5.30355" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1091" /TUdmin=0 /isTUend="TRUE" S_feature complement(1414827..1414907) /Source="Nicolas_S_feature" /locus_tag="new_1414827_1414907_c" /HighExp="LBGtran, dia0, LBGexp, Lbexp, Oxctl, G180, M0t45, C90, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S482" promotor_-10 complement(1414899..1414918) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1414907) /Source="Nicolas_upshifts" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" promotor_-35 1414923..1414930 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1414932..1414939) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1414944..1414963 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1414951 /Source="Nicolas_upshifts" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" CDS 1414997..1415893 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11860552, 12081643, 16076848, 16573693, 22447908, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane protease" /protein_id="NP_389232.1" /db_xref="EnsemblGenomes-Gn:BSU13490" /db_xref="EnsemblGenomes-Tr:CAB13222" /db_xref="GOA:O31657" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR022919" /db_xref="SubtiList:BG13274" /db_xref="UniProtKB/Swiss-Prot:O31657" /translation="MAKRIFLFILTNILVLTTIGIVLSVLSSVTGVGTYFTADGGIDP MALLVFSLVVGFVGSFTSLAISRWMAKTMMGVRVLNPKKHSLSYEEQQLVDRVHRLSR SAGLTKMPEVGIYRSPEVNAFATGPSKRRSLVAVSSGLLEQMDDAAVEGVLAHEVAHI TNGDMVTMTLLQGIVNTFVVFLSRIAAWIASRFVKEDLAPIVHFIAMIIFQIVFSILG SLVVFAYSRHREFHADRGGADLAGKDKMIHALRTLKSYSSRILEDDQTAVQTLKINGK KRSSLFSTHPDLDERIRRLEAK*" gene 1414997..1415893 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" downshifts 1415887 /Source="Nicolas_upshifts" /id="D740" /incds=0 /nref=203 /ntot=268 /MaxReadThrough="3.02778" /MaxDrop="6.27746" /score="38.5173589" /energy="-13.4" /TU="NA" /idTUdmin="U1092" /TUdmin=0 /isTUend="TRUE" promotor_-35 1415998..1416002 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1416018..1416037 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1416022 /Source="Nicolas_upshifts" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" CDS 1416067..1417416 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" /EC_number="3.6.3.12" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 23963175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 23963175; Product type t : transporter" /codon_start=1 /transl_table=11 /product="K+-transporting ATPase" /protein_id="NP_389233.1" /db_xref="EnsemblGenomes-Gn:BSU13500" /db_xref="EnsemblGenomes-Tr:CAB13223" /db_xref="GOA:O31658" /db_xref="InterPro:IPR003445" /db_xref="SubtiList:BG13275" /db_xref="UniProtKB/Swiss-Prot:O31658" /translation="MRLKFGKLIQALSPAQLIALYYFLAVTVAVILLSLPAAHKPGAD WTFIDALFTAVSSVSVTGLTVVDTADTFSTIGIFILAFVLQFGGIGIMTLGTFIWLIM GKRIGLKERKLIMVDQNQSQFSGIVNLMKQVLFLILWIEFFGGLILGTYFLTYYDSYQ EAYLHGFFASISATTNGGFDITGNSMIPFRHDYFVQFITMLLIIFGAIGFPVLVEVKD FLFSKHRRYPFTLFTKITTITFGSLVLFGAIGIFALEANHAFAGKSWHDILFLSLFQS TATRSGGLATIDISQLSDSTLFFICALMFIGASPSSVGGGIRTTTFALNLLALFHFAR GNKAVKVFKRELHPADLMKSLVVTMMAILLVFGATLILTITEKHSLLELLFEVCSAFG TTGLSLGITADLSSVGKCVIMIVMFIGRIGILTFLYLIGRKEIEANYHYPKERVIIG* " gene 1416067..1417416 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" downshifts 1417404 /Source="Nicolas_upshifts" /id="D741" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="0.838800000000001" /MaxDrop="4.37717" /score="20.0478288" /energy="-10.7" /TU="NA" /idTUdmin="U1093" /TUdmin="-1" /isTUend="TRUE" promotor_-35 1417465..1417471 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1417485..1417496 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1417493..1417560 /Source="Nicolas_S_feature" /locus_tag="new_1417493_1417560" /HighExp="S8, S6, S7, S5, ferm, nit, BT, B36, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S483" upshifts 1417493 /Source="Nicolas_upshifts" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" CDS 1417561..1417716 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097718.1" /db_xref="EnsemblGenomes-Gn:BSU13509" /db_xref="EnsemblGenomes-Tr:CAX52609" /db_xref="UniProtKB/Swiss-Prot:C0H402" /translation="MKRKAEVNEAIKNNNTPTESMDPNSYKTQYHDDPNFRGANRNSK QGQQGGM*" gene 1417561..1417716 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" CDS 1417719..1417895 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389234.1" /db_xref="EnsemblGenomes-Gn:BSU13510" /db_xref="EnsemblGenomes-Tr:CAB13224" /db_xref="SubtiList:BG13333" /db_xref="UniProtKB/Swiss-Prot:O31659" /translation="MKKNRHSRDMQNHKKPMNKKVLEEEFSSELGDYNAGKIIETLEV TKPEKKKEKNKKQQ*" gene 1417719..1417895 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" promotor_no_box 1417785..1417885 /Source="Nicolas_upshift_promotors" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1417845 /Source="Nicolas_upshifts" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1417891 /Source="Nicolas_upshifts" /id="D742" /incds=0 /nref=56 /ntot=112 /MaxReadThrough="2.40289" /MaxDrop="8.38761" /score="26.5107018" /energy="-19.7" /TU="NA" /idTUdmin="U1094" /TUdmin=2 /isTUend="TRUE" CDS complement(1417938..1418960) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" /EC_number="2.3.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative integral membrane protein; putative acyltransferase" /protein_id="NP_389235.1" /db_xref="EnsemblGenomes-Gn:BSU13520" /db_xref="EnsemblGenomes-Tr:CAB13225" /db_xref="GOA:O31660" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG13276" /db_xref="UniProtKB/Swiss-Prot:O31660" /translation="MSKSRDSYFDNAKFLLIFLVVFGHILRSFINDNHFMLYLYKFIY TFHMPAFILVSGYFAKGFKRAGYVKKLAVKLIIPYLIFQIIYSVFYYIMQDESMANVN PIDPQWSLWFLVSLFFWNLLLYPFSKLSKQWALFVSCGIAVLIGYLDFVSSTLSLSRT FVFLPMFLVGFYLNKHHFDLLRSKRGKQIALGVLAAVFVICWGIDFDYSFLFGSKPYS SFGDVTLVSGLSRIGWYVLAFGATFSFLALVPQKRYFFTKWGTRTFYVYLLHGFIIKT LRQVGLEDWLTDYQSLVILLLLTAALTSVLSSNFVKTVAQPFIELRMTSLLQFVRGTG KNAYLK*" gene complement(1417938..1418960) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" downshifts complement(1417961) /Source="Nicolas_upshifts" /id="D743" /incds=0 /nref=11 /ntot=58 /MaxReadThrough="2.29259" /MaxDrop="3.64731" /score="30.4184602" /energy="-16.9" /TU="NA" /idTUdmin="U1096" /TUdmin=92 /isTUend="FALSE" promotor_-10 complement(1419005..1419024) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1419021) /Source="Nicolas_upshifts" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" promotor_-35 complement(1419036..1419042) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1419149..1419157 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1419165 /Source="Nicolas_upshifts" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" promotor_-10 1419168..1419186 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1419213..1421429 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11069677, 12169614, 16166384, 25701730" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 12169614, 16166384, 25701730; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_389236.1" /db_xref="EnsemblGenomes-Gn:BSU13530" /db_xref="EnsemblGenomes-Tr:CAB13226" /db_xref="GOA:O31661" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13277" /db_xref="UniProtKB/Swiss-Prot:O31661" /translation="METLGVQTNSELREELNRLKEENARLKKELNQHQVIVNNTLDAI FICDNEMRIVQANEATERMLQVDSEDLKKRSVLDFLFSIPKDELNLSVKKFFKKGFLW KEVPIRLDCGATKYIEFLAKRGIGEDFFFVVMRDISSKKILEREFSMNEQLFKDLFDR AVDGIVLFDKDGGFIDANLSFCKSFEINHNELSHLSLYEFIDSGSRKDFDNIWKALNR KGKAKGELPVKLRSGVQKLFEFTITSNIISGFYMSIMRDITEKRSMELQLFKSEERFR EIFENAMDAIIIWSNDGRIVKANQSACKIFELPMNLLLKRKLCDFLVDSQQKYSITKR KYAKYGEIREELLFQMGNGQFKELEFTSKRTILENQHLTILRNVSDRKRMEKELRESE LKFRKVFNGSMDGNVLFDNQYRIIDANPLASHILGLSHEEIKQHSLLDIISAYEIENL ASPARQINFDEMDNEIPFLLSSGDNRKLEFSFKRNIIQNMNLAIFKDVTERKELEERL RKSDTLHVVGELAAGIAHEIRNPMTALKGFIQLLKGSVEGDYALYFNVITSELKRIES IITEFLILAKPQAIMYEEKHVTQIMRDTIDLLNAQANLSNVQMQLDLIDDIPPIYCEP NQLKQVFINILKNAIEVMPDGGNIFVTIKALDQDHVLISLKDEGIGMTEDKLKRLGEP FYTTKERGTGLGLMVSYKIIEEHQGEIMVESEEGKGTVFHITLPVRQNAEERRNDE*" gene 1419213..1421429 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" S_feature complement(1421204..1422144) /Source="Nicolas_S_feature" /locus_tag="new_1421204_1422144_c" /HighExp="Pyr, Glucon, C30, Glu, Mal, M/G, G/S, Heat, Fru, B36" /AntisenseName="ogt" /AntisenseCor="-0.33210294457391598" /AntisenseRegPval="-7.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S484" promotor_-35 1421282..1421289 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1421304..1421323 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1421306 /Source="Nicolas_upshifts" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" CDS 1421426..1421923 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" /EC_number="2.1.1.63" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2105461, 2308822, 2359121, 2506524, 7565865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105461, 2308822, 2359121, 2506524, 7565865; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O6-alkylguanine DNA alkyltransferase" /protein_id="NP_389237.1" /db_xref="EnsemblGenomes-Gn:BSU13540" /db_xref="EnsemblGenomes-Tr:CAB13227" /db_xref="GOA:P11742" /db_xref="InterPro:IPR001497" /db_xref="InterPro:IPR008332" /db_xref="InterPro:IPR014048" /db_xref="InterPro:IPR023546" /db_xref="InterPro:IPR036217" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036631" /db_xref="SubtiList:BG10848" /db_xref="UniProtKB/Swiss-Prot:P11742" /translation="MNYYTTAETPLGELIIAEEEDRITRLFLSQEDWVDWKETVQNTE HKETPNLAEAKQQLQEYFAGERKTFSLPLSQKGTPFQQKVWQALERIPYGESRSYADI AAAVGSPKAVRAVGQANKRNDLPIFVPCHRVIGKNSALTGYAGSKTEIKAFLLNIERI SYKEK*" gene 1421426..1421923 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" S_feature 1421924..1422163 /Source="Nicolas_S_feature" /locus_tag="new_1421924_1422163" /HighExp="Lbstat, S2, BT, BC, LPhT, dia15, LBGstat, M0t90, M9-stat, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.981549" /TUshortSig="SigA, SigH" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S485" CDS 1422013..1422138 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513954.1" /translation="MKPSRSEKLAVFAELFVKLHILSSAQKDEIINVNKKKQKNR*" gene 1422013..1422138 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" downshifts 1422131 /Source="Nicolas_upshifts" /id="D744" /incds=0 /nref=80 /ntot=239 /MaxReadThrough="1.90528" /MaxDrop="5.2481" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin="-4" /isTUend="TRUE" CDS complement(1422172..1423233) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" /EC_number="5.3.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14551435, 15102328, 16511105, 17690466, 18156470" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14551435, 15102328, 16511105, 17690466, 18156470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose-1-phosphate isomerase (methionine salvage pathway)" /protein_id="NP_389238.1" /db_xref="EnsemblGenomes-Gn:BSU13550" /db_xref="EnsemblGenomes-Tr:CAB13228" /db_xref="GOA:O31662" /db_xref="InterPro:IPR000649" /db_xref="InterPro:IPR005251" /db_xref="InterPro:IPR011559" /db_xref="InterPro:IPR027363" /db_xref="PDB:2YRF" /db_xref="PDB:2YVK" /db_xref="SubtiList:BG13278" /db_xref="UniProtKB/Swiss-Prot:O31662" /translation="MTHSFAVPRSVEWKETAITILNQQKLPDETEYLELTTKEDVFDA IVTLKVRGAPAIGITAAFGLALAAKDIETDNVTEFRRRLEDIKQYLNSSRPTAINLSW ALERLSHSVENAISVNEAKTNLVHEAIQIQVEDEETCRLIGQNALQLFKKGDRIMTIC NAGSIATSRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLI TDSMAAHTMKEKQISAVIVGADRIAKNGDTANKIGTYGLAILANAFDIPFFVAAPLST FDTKVKCGADIPIEERDPEEVRQISGVRTAPSNVPVFNPAFDITPHDLISGIITEKGI MTGNYEEEIEQLFKGEKVH*" gene complement(1422172..1423233) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" downshifts complement(1422189) /Source="Nicolas_upshifts" /id="D745" /incds=0 /nref=261 /ntot=286 /MaxReadThrough="4.47312" /MaxDrop="7.97339" /score="34.04363" /energy="-17.1" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-418" /isTUend="FALSE" CDS complement(1423241..1424434) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" /EC_number="2.7.1.100" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:210167, 11545674, 15102328, 17522047, 23649237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 210167, 11545674, 15102328, 17522047, 23649237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose kinase (methionine salvage pathway, promiscuous)" /protein_id="NP_389239.2" /db_xref="EnsemblGenomes-Gn:BSU13560" /db_xref="EnsemblGenomes-Tr:CAB13229" /db_xref="GOA:O31663" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR009212" /db_xref="InterPro:IPR011009" /db_xref="PDB:2OLC" /db_xref="PDB:2PU8" /db_xref="PDB:2PUI" /db_xref="PDB:2PUL" /db_xref="PDB:2PUN" /db_xref="PDB:2PUP" /db_xref="SubtiList:BG13279" /db_xref="UniProtKB/Swiss-Prot:O31663" /translation="MGVTKTPLYETLNESSAVALAVKLGLFPSKSTLTCQEIGDGNLN YVFHIYDQEHDRALIIKQAVPYAKVVGESWPLTIDRARIESSALIRQGEHVPHLVPRV FYSDTEMAVTVMEDLSHLKIARKGLIEGENYPHLSQHIGEFLGKTLFYSSDYALEPKV KKQLVKQFTNPELCDITERLVFTDPFFDHDTNDFEEELRPFVEKLWNNDSVKIEAAKL KKSFLTSAETLIHGDLHTGSIFASEHETKVIDPEFAFYGPIGFDVGQFIANLFLNALS RDGADREPLYEHVNQVWETFEETFSEAWQKDSLDVYANIDGYLTDTLSHIFEEAIGFA GCELIRRTIGLAHVADLDTIVPFDKRIGRKRLALETGTAFIEKRSEFKTITDVIELFK LLVKE*" gene complement(1423241..1424434) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" downshifts 1423301 /Source="Nicolas_upshifts" /id="D746" /incds=1 /nref=1 /ntot=51 /MaxReadThrough="3.02938" /MaxDrop="3.49719" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin=1166 /isTUend="FALSE" downshifts complement(1424521) /Source="Nicolas_upshifts" /id="D747" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="8.61071" /MaxDrop="3.05641" /score="27.7981655" /energy="-17.6" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-2750" /isTUend="FALSE" misc_RNA complement(1424527..1424683) /gene="mswC" /locus_tag="BSU_misc_RNA_20" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="12: Regulatory functions" gene complement(1424527..1424683) /gene="mswC" /locus_tag="BSU_misc_RNA_20" promotor_-10 complement(1424718..1424737) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1424719) /Source="Nicolas_upshifts" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" promotor_-35 complement(1424753..1424760) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1424763..1424766 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1424767..1425546) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" /EC_number="3.5.1.3" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12022921, 19464248, 19596042, 21288482, 23944997, 24387040; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ketoglutaramate omega-amidase" /protein_id="NP_389240.1" /db_xref="EnsemblGenomes-Gn:BSU13570" /db_xref="EnsemblGenomes-Tr:CAB13230" /db_xref="GOA:O31664" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG13280" /db_xref="UniProtKB/Swiss-Prot:O31664" /translation="MKWTISCLQFDISYGKPSENIKKAEFFIEKESKHADVLVLPELW TTGYDLANLDELADEDGRSAQSWLKKTAKKHGVHIVAGSVAVRKNSDVYNTMYIADKE GQIIKEYRKAHLFQLMDEHLYLSAGSEDGYFELDGVKSSGLICYDIRFPEWIRKHTTK GANVLFISAEWPLPRLDHWKSLLIARAIENQCFVAACNCTGSNPDNEFAGHSLIIDPW GRVLAEGGREEGIVRAEIDLQESAEVRESIPVFDDIRKDLY*" gene complement(1424767..1425546) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" promotor_-10 1424782..1424801 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1424791 /Source="Nicolas_upshifts" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 1425239..1425246 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-35" promotor_-10 1425259..1425278 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-10" upshifts 1425274 /Source="Nicolas_upshifts" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" S_feature 1425281..1425598 /Source="Nicolas_S_feature" /locus_tag="new_1425281_1425598" /HighExp="LoTm, S8, C30, BC, S7, B36, B60, T2.0H, Sw, UNK1" /AntisenseName="mtnU" /AntisenseCor="0.77659263363209297" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S486" promotor_-35 1425568..1425575 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1425576..1425595) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1425590..1425609 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1425590) /Source="Nicolas_upshifts" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" upshifts 1425600 /Source="Nicolas_upshifts" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" promotor_-35 complement(1425611..1425618) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1425641..1426837 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" /EC_number="2.6.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15102328, 23429746, 24387040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15102328, 23429746, 24387040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine-glutamine aminotransferase" /protein_id="NP_389241.1" /db_xref="EnsemblGenomes-Gn:BSU13580" /db_xref="EnsemblGenomes-Tr:CAB13231" /db_xref="GOA:O31665" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13281" /db_xref="UniProtKB/Swiss-Prot:O31665" /translation="MKFEQSHVLKELPKQFFASLVQKVNRKLAEGHDVINLGQGNPDQ PTPEHIVEEMKRAVADPENHKYSSFRGSYRLKSAAAAFYKREYGIDLDPETEVAVLFG GKAGLVELPQCLLNPGDTILVPDPGYPDYWSGVTLAKAKMEMMPLVKDRAFLPDYSSI TAEIREQAKLMYLNYPNNPTGAVATSEFFEDTVRFAAENGICVVHDFAYGAVGFDGCK PLSFLQTEGAKDIGIEIYTLSKTYNMAGWRVGFAVGNASVIEAINLYQDHMFVSLFRA TQEAAAEALLADQTCVAEQNARYESRRNAWITACREIGWDVTAPAGSFFAWLPVPEGY TSEQFSDLLLEKANVAVAAGNGFGEYGEGYVRVGLLTSEERLKEAAYRIGKLNLFTQK SIDKTL*" gene 1425641..1426837 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" promotor_-35 1426819..1426826 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1426841..1426860 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1426860 /Source="Nicolas_upshifts" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" misc_RNA 1426876..1426976 /gene="mswD" /locus_tag="BSU_misc_RNA_21" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="16.3: Control" gene 1426876..1426976 /gene="mswD" /locus_tag="BSU_misc_RNA_21" downshifts 1426975 /Source="Nicolas_upshifts" /id="D748" /incds=0 /nref=49 /ntot=190 /MaxReadThrough="7.27369" /MaxDrop="4.19981" /score="-1.80590532" /energy="-10.7" /TU="U1103,U1104" /idTUdmin="U1101" /TUdmin=110 /isTUend="FALSE" CDS 1427061..1428278 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" /EC_number="5.3.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 16737967, 18403380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 16737967, 18403380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2,3-diketo-5-methylthiopentyl-1-phosphate enolase (DK-MTP-1-P enolase)" /protein_id="NP_389242.2" /db_xref="EnsemblGenomes-Gn:BSU13590" /db_xref="EnsemblGenomes-Tr:CAB13232" /db_xref="GOA:O31666" /db_xref="InterPro:IPR000685" /db_xref="InterPro:IPR017443" /db_xref="InterPro:IPR017717" /db_xref="InterPro:IPR033966" /db_xref="InterPro:IPR036376" /db_xref="InterPro:IPR036422" /db_xref="PDB:2ZVI" /db_xref="SubtiList:BG13282" /db_xref="UniProtKB/Swiss-Prot:O31666" /translation="MSELLATYLLTEPGADTEKKAEQIATGLTVGSWTDLPLVKQEQM QKHKGRVIKVEEREGTAASEKQAVITIAYPEINFSQDIPALLTTVFGKLSLDGKIKLI DLHFSEAFKRALPGPKFGVYGIRKLLGEFERPLLMSIFKGVIGRDLSDIKEQLRQQAL GGVDLIKDDEIFFETGLAPFETRIAEGKQILKETYEQTGHKTLYAVNLTGRTADLKDK ARRAAELGADALLFNVFAYGLDVMQGLAEDPEIPVPIMAHPAVSGAFTSSPFYGFSHA LLLGKLNRYCGADFSLFPSPYGSVALPRADALAIHEECVREDAFNQTFAVPSAGIHPG MVPLLMRDFGIDHIINAGGGVHGHPNGAQGGGRAFRAIIDAVLEAQPIDEKAEQCKDL KLALDKWGKAEAV*" gene 1427061..1428278 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" CDS 1428275..1428982 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" /EC_number="3.1.3.87" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 17654724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 17654724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxy-3-keto-5-methylthiopentenyl-1- phosphatephosphatase (HK-MTPenyl-1-P phosphatase)" /protein_id="NP_389243.1" /db_xref="EnsemblGenomes-Gn:BSU13600" /db_xref="EnsemblGenomes-Tr:CAB13233" /db_xref="GOA:O31667" /db_xref="InterPro:IPR006384" /db_xref="InterPro:IPR017718" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:2FEA" /db_xref="SubtiList:BG13283" /db_xref="UniProtKB/Swiss-Prot:O31667" /translation="MTTRKPFIICDFDGTITMNDNIINIMKTFAPPEWMALKDGVLSK TLSIKEGVGRMFGLLPSSLKEEITSFVLEDAKIREGFREFVAFINEHEIPFYVISGGM DFFVYPLLEGIVEKDRIYCNHASFDNDYIHIDWPHSCKGTCSNQCGCCKPSVIHELSE PNQYIIMIGDSVTDVEAAKLSDLCFARDYLLNECREQNLNHLPYQDFYEIRKEIENVK EVQEWLQNKNAGESSLK*" gene 1428275..1428982 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" CDS 1428940..1429569 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" /EC_number="4.2.1.109" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 18391471, 23285211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 18391471, 23285211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase)" /protein_id="NP_389244.1" /db_xref="EnsemblGenomes-Gn:BSU13610" /db_xref="EnsemblGenomes-Tr:CAB13234" /db_xref="GOA:O31668" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR017714" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG13284" /db_xref="UniProtKB/Swiss-Prot:O31668" /translation="MAAKQERWRELAEVKRELAERDWFPATSGNLSIKVTDEPLTFLV TASGKDKRKETVEDFLLVDQNGEPAESGHSLKPSAETLLHTHLYNKTNAGCCLHVHTV NNNVISELYGDQKKITFKGQEIIKALGLWEENAEVTVPIIENPAHIPTLAALFAEEIS EDSGAVLIRNHGITAWGKTAFEAKRVLEAYEFLFSYHLKLKTLEHQLVK*" gene 1428940..1429569 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" CDS 1429584..1430120 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" /EC_number="1.13.11.54" /EC_number="1.13.11.53" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acireductone dioxygenase (Ni2+ or Fe2+-requiring)" /protein_id="NP_389245.1" /db_xref="EnsemblGenomes-Gn:BSU13620" /db_xref="EnsemblGenomes-Tr:CAB13235" /db_xref="GOA:O31669" /db_xref="InterPro:IPR004313" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR023956" /db_xref="SubtiList:BG13285" /db_xref="UniProtKB/Swiss-Prot:O31669" /translation="MATIRIHDEANTTIENQEEVASFLDSQEVIYEQWDITRLPEHLS EKYDLTEEEKQQILDTFETEIKDISTRRGYKAQDVISLSDSNPKLDELLENFKREHHH TDDEVRFIVSGHGIFVIQGQDGTFFDVRLNPGDLISVPENIRHYFTLQEDRKVVAVRI FVTTEGWVPIYEKDSVNQ*" gene 1429584..1430120 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" S_feature complement(1429967..1430160) /Source="Nicolas_S_feature" /locus_tag="new_1429967_1430160_c" /HighExp="Lbstat, Cold, LBGstat, T0.30H, M9-stat, B60, ferm, T1.30H, LPhT, M0t90" /AntisenseName="mtnD" /AntisenseCor="-0.31139057410816301" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S487" downshifts 1430120 /Source="Nicolas_upshifts" /id="D749" /incds=0 /nref=179 /ntot=227 /MaxReadThrough="1.58976" /MaxDrop="6.10661" /score="35.4563733" /energy="-14.9" /TU="NA" /idTUdmin="U1103" /TUdmin="-1" /isTUend="TRUE" CDS complement(1430161..1430481) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389246.1" /db_xref="EnsemblGenomes-Gn:BSU13630" /db_xref="EnsemblGenomes-Tr:CAB13236" /db_xref="GOA:O31670" /db_xref="InterPro:IPR010652" /db_xref="SubtiList:BG13308" /db_xref="UniProtKB/Swiss-Prot:O31670" /translation="MKKKKAIMLGAAGGKAILKRKNRKKCIQHITTFFQMLRDWRNGD YPRSQVKTLLLLTAAILYIVMPLDIIPDVILGLGFIDDAAVLGLIWTLIKKELSQYEK WRLQ*" gene complement(1430161..1430481) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" downshifts complement(1430219) /Source="Nicolas_upshifts" /id="D750" /incds=0 /nref=5 /ntot=148 /MaxReadThrough="4.05831" /MaxDrop="2.74575" /score="18.5455371" /energy="-11.3" /TU="U1106" /idTUdmin="U1106" /TUdmin="-220" /isTUend="FALSE" S_feature complement(1430482..1430571) /Source="Nicolas_S_feature" /locus_tag="new_1430482_1430571_c" /HighExp="Lbstat, M9-stat, B60, T0.30H, LBGstat, M0t90, T1.0H, S2, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S488" promotor_-35 1430507..1430513 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1430528..1430546 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1430538 /Source="Nicolas_upshifts" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" S_feature 1430539..1430623 /Source="Nicolas_S_feature" /locus_tag="new_1430539_1430623" /HighExp="Etha, Gly, BC, Salt, Sw, B60, LoTm, M9-stat, LPhT, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S489" promotor_-10 complement(1430553..1430572) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1430570) /Source="Nicolas_upshifts" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" promotor_-35 complement(1430587..1430590) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1430597..1430604 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1430619..1430638 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1430625..1430683 /Source="Nicolas_S_feature" /locus_tag="new_1430625_1430683" /HighExp="Etha, Gly, Sw, BC, LoTm, B36, T3.30H, Salt, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S490" upshifts 1430625 /Source="Nicolas_upshifts" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" downshifts complement(1430681) /Source="Nicolas_upshifts" /id="D751" /incds=0 /nref=3 /ntot=61 /MaxReadThrough="0.87927" /MaxDrop="3.53961" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1106" /TUdmin="-682" /isTUend="FALSE" CDS 1430684..1430941 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15057450, 15916600, 17001075, 19332814, 22524514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15057450, 15916600, 17001075, 19332814, 22524514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="negative regulatory phosphatase acting on Spo0A-P (sporulation)" /protein_id="NP_389247.1" /db_xref="EnsemblGenomes-Gn:BSU13640" /db_xref="EnsemblGenomes-Tr:CAB13237" /db_xref="GOA:P05043" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG10769" /db_xref="UniProtKB/Swiss-Prot:P05043" /translation="MGGSSEQERLLVSIDEKRKLMIDAARKQGFTGHDTIRHSQELDC LINEYHQLMQENEHSQGIQGLVKKLGLWPRRDVMPAYDANK*" gene 1430684..1430941 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" downshifts 1430935 /Source="Nicolas_upshifts" /id="D752" /incds=0 /nref=7 /ntot=169 /MaxReadThrough="4.39402" /MaxDrop="3.59614" /score="0.224700481" /energy="-5.9" /TU="U1105,U1107" /idTUdmin="U1105" /TUdmin="-440" /isTUend="FALSE" CDS 1431027..1431458 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative small membrane protein" /protein_id="NP_389248.1" /db_xref="EnsemblGenomes-Gn:BSU13650" /db_xref="EnsemblGenomes-Tr:CAB13238" /db_xref="GOA:P06630" /db_xref="SubtiList:BG10770" /db_xref="UniProtKB/Swiss-Prot:P06630" /translation="MKELAILITEMVNQFHDAFISLCGIFGIHLTDKEMHFWVIGIFG IFFFGVTHAVFTWLSKWSMTALSFIYTVTVIIVIVFAIEIQQKVTGRGNMEFLDATEG IKGFLVFFMFFLLLKMLLRFIKILFSGRPASKSNGNARSRR*" gene 1431027..1431458 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" CDS complement(1431486..1433006) /gene="kinD" /locus_tag="BSU_13660" /old_locus_tag="BSU13660" /EC_number="2.7.13.3" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11069677, 11673427, 16166384, 10411754, 21622736, 22074846, 22716461, 23569226" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 11673427, 16166384, 10411754, 21622736, 22074846, 22716461, 23569226; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidine kinase phosphorylating Spo0A" /protein_id="NP_389249.1" /db_xref="EnsemblGenomes-Gn:BSU13660" /db_xref="EnsemblGenomes-Tr:CAB13239" /db_xref="GOA:O31671" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:4JGO" /db_xref="PDB:4JGP" /db_xref="PDB:4JGQ" /db_xref="PDB:4JGR" /db_xref="SubtiList:BG13309" /db_xref="UniProtKB/Swiss-Prot:O31671" /translation="MLERCKLKILKGACGRVKLYIILVVIPAIVISFFVYEKEKDTIA AEHKQEASVLLNLHRNKINYLIGETMARMTSLSIAIDRPVDIKKMQSILEKTFDSEPR FSGLYFLNAKGDVTASTTELKTKVNLADRSFFIKAKETKKTVISDSYSSRITGQPIFT ICVPVLDSKRNVTDYLVAAIQIDYLKNLINLLSPDVYIEVVNQDGKMIFASGQASHAE DQKPVSGYLDDISWNMKVYPNPVTIEELSKSLVLPLSCIIVLLNILFILVLYYLLKRQ TQLERSENEAQKLELIGTLAASTAHEIRNPLTGISGFIQLLQKKYKGEEDQLYFSIIE QEIKRINQIVSEFLVLGKPTAEKWELNSLQDIIGEIMPIIYSEGNLYNVEVELQYLTE QPLLVKCTKDHIKQVILNVAKNGLESMPEGGKLTISLGALDKKAIIKVVDNGEGISQE MLDHIFLPFVTSKEKGTGLGLVVCKRIVLMYGGSIHIESEVRRGTEVTITLPVSAS*" gene complement(1431486..1433006) /gene="kinD" /locus_tag="BSU_13660" /old_locus_tag="BSU13660" downshifts complement(1431498) /Source="Nicolas_upshifts" /id="D753" /incds=0 /nref=106 /ntot=227 /MaxReadThrough="0.62895" /MaxDrop="5.24795" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1109" /TUdmin="-3" /isTUend="TRUE" promotor_-35 1432207..1432213 /Source="Nicolas_upshift_promotors" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1432227..1432238 /Source="Nicolas_upshift_promotors" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1432233 /Source="Nicolas_upshifts" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(1433014..1433033) /Source="Nicolas_upshift_promotors" /id="U1109" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2145 /SigmaFactorBS="aagcttgccaacatctttttctaatttttttggttatttttt cttattaaagaagaagaaacAATGATATAATACCTCTAATcaggtgtatgttggagcg a" /listShort="kinD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1433035) /Source="Nicolas_upshifts" /id="U1109" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2145 /SigmaFactorBS="aagcttgccaacatctttttctaatttttttggttatttttt cttattaaagaagaagaaacAATGATATAATACCTCTAATcaggtgtatgttggagcg a" /listShort="kinD" /GFF_Attribute="listLong" promotor_-35 1433133..1433140 /Source="Nicolas_upshift_promotors" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1433155..1433174 /Source="Nicolas_upshift_promotors" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1433157 /Source="Nicolas_upshifts" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" CDS 1433199..1433636 /gene="mhqR" /locus_tag="BSU_13670" /old_locus_tag="BSU13670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17725564, 17962296, 18282125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17725564, 17962296, 18282125; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family)" /protein_id="NP_389250.1" /db_xref="EnsemblGenomes-Gn:BSU13670" /db_xref="EnsemblGenomes-Tr:CAB13240" /db_xref="GOA:O31672" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13310" /db_xref="UniProtKB/Swiss-Prot:O31672" /translation="MTEKSLKLFIVLSRAYRSINDHMNKHIHKHGLNPTEFAVLELLY HKGDQPLQQIGDKILLASGSITYVVDKLEQKELLIRKASPTDRRVTFAQITEKGIGLL NDIFPDHAAEIDEMISVLSEEEVEMCTEMLKRVGLNAKQFHNK*" gene 1433199..1433636 /gene="mhqR" /locus_tag="BSU_13670" /old_locus_tag="BSU13670" downshifts 1433619 /Source="Nicolas_upshifts" /id="D754" /incds=0 /nref=210 /ntot=257 /MaxReadThrough="1.20686" /MaxDrop="5.47215" /score="1.59181784" /energy="-8.9" /TU="U1110" /idTUdmin="U1110" /TUdmin="-22" /isTUend="TRUE" CDS complement(1433676..1434461) /gene="motB" /locus_tag="BSU_13680" /old_locus_tag="BSU13680" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16095621, 18566286, 24296669, 24771657, 25273986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16095621, 18566286, 24296669, 24771657, 25273986; Product type f: factor" /codon_start=1 /transl_table=11 /product="motility protein B; MotB component of the H+-coupled stator flagellum complex" /protein_id="NP_389251.1" /db_xref="EnsemblGenomes-Gn:BSU13680" /db_xref="EnsemblGenomes-Tr:CAB13241" /db_xref="GOA:P28612" /db_xref="InterPro:IPR006665" /db_xref="InterPro:IPR025713" /db_xref="InterPro:IPR036737" /db_xref="SubtiList:BG10689" /db_xref="UniProtKB/Swiss-Prot:P28612" /translation="MARKKKKKHEDEHVDESWLVPYADILTLLLALFIVLYASSSIDA AKFQMLSKSFNEVFTGGTGVLDYSSVTPPENESDGIDEVKKEKEEKEKNKKEKEKAAD QEELENVKSQVEKFIKDKKLEHQLETKMTSEGLLITIKDSIFFDSGKATIRKEDVPLA KEISNLLVINPPRNIIISGHTDNMPIKNSEFQSNWHLSVMRAVNFMGLLIENPKLDAK VFSAKGYGEYKPVASNKTAEGRSKNRRVEVLILPRGAAETNEK*" gene complement(1433676..1434461) /gene="motB" /locus_tag="BSU_13680" /old_locus_tag="BSU13680" downshifts complement(1433695) /Source="Nicolas_upshifts" /id="D755" /incds=0 /nref=224 /ntot=246 /MaxReadThrough="3.05351" /MaxDrop="6.69306" /score="21.3673767" /energy="-12.4" /TU="U1111" /idTUdmin="U1111" /TUdmin="-88" /isTUend="FALSE" downshifts complement(1434157) /Source="Nicolas_upshifts" /id="D756" /incds=1 /nref=1 /ntot=19 /MaxReadThrough="8.03566" /MaxDrop="4.69358" /score="21.3673767" /energy="-12.4" /TU="U1111" /idTUdmin="U1111" /TUdmin="-550" /isTUend="FALSE" CDS complement(1434433..1435245) /gene="motA" /locus_tag="BSU_13690" /old_locus_tag="BSU13690" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16095621, 18566286, 24296669, 24771657, 25273986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16095621, 18566286, 24296669, 24771657, 25273986; Product type f: factor" /codon_start=1 /transl_table=11 /product="motility protein A; MotA component of the H+-coupled stator flagellum complex" /protein_id="NP_389252.1" /db_xref="EnsemblGenomes-Gn:BSU13690" /db_xref="EnsemblGenomes-Tr:CAB13242" /db_xref="GOA:P28611" /db_xref="InterPro:IPR000540" /db_xref="InterPro:IPR002898" /db_xref="SubtiList:BG10688" /db_xref="UniProtKB/Swiss-Prot:P28611" /translation="MDKTSLIGIILAFVALSVGMVLKGVSFSALANPAAILIIIAGTI SAVVIAFPTKEIKKVPTLFRVLFKENKQLTIEELIPMFSEWAQLARREGLLALEASIE DVDDAFLKNGLSMAVDGQSAEFIRDIMTEEVEAMEDRHQAGAAIFTQAGTYAPTLGVL GAVIGLIAALSHMDNTDELGHAISAAFVATLLGIFTGYVLWHPFANKLKRKSKQEVKL REVMIEGVLSVLEGQAPKVIEQKLLMYLPAKDRLKFAEQGEAQNGEKKEEEA*" gene complement(1434433..1435245) /gene="motA" /locus_tag="BSU_13690" /old_locus_tag="BSU13690" promotor_-10 complement(1435276..1435294) /Source="Nicolas_upshift_promotors" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1435292) /Source="Nicolas_upshifts" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" promotor_-35 complement(1435308..1435315) /Source="Nicolas_upshift_promotors" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1435383..1435605) /Source="Nicolas_S_feature" /locus_tag="new_1435383_1435605_c" /HighExp="Diami, dia15, dia5, Heat, Etha, LPhT, H2O2, C30, G135, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.93062599999999995" /TUshortSig="SigA" /TUshortPSig="0.671" /TUlongSig="NA" /TUlongPSig="NA" /label="S491" downshifts complement(1435415) /Source="Nicolas_upshifts" /id="D757" /incds=0 /nref=5 /ntot=12 /MaxReadThrough="0.48394" /MaxDrop="4.60081" /score="30.9355071" /energy="-15.4" /TU="NA" /idTUdmin="U1112" /TUdmin="-4" /isTUend="TRUE" CDS complement(1435628..1437727) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease (class III stress gene)" /protein_id="NP_389253.1" /db_xref="EnsemblGenomes-Gn:BSU13700" /db_xref="EnsemblGenomes-Tr:CAB13243" /db_xref="GOA:O31673" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="SubtiList:BG12578" /db_xref="UniProtKB/Swiss-Prot:O31673" /translation="MRCQHCHQNEATIRLNMQINSVHKQMVLCETCYNELTRKPSMSM GPQSFGFPFEQAFQPKEQSAAKQSEKKGLLDELAQNITNGAKAGLIDPVIGRDDEVAR VIEILNRRNKNNPVLIGEPGVGKTAIAEGLALKIAEGDVPNKLKNKELYLLDVASLVA NTGIRGQFEERMKQLITELKERKNVILFIDEIHLLVGAGSAEGSMDAGNILKPALARG ELQVIGATTLKEYRQIEKDAALERRFQPVMVQEPSIEQAILILQGIKDKYEAYHGVTF SDEAIKACVTLSSRYIQDRHLPDKAIDLLDEAGSKANLLIDELNDEDAAERLTAIEAE KTKALEEENYELAAKLRDEELALEKKLNSSSAHTAVTVEAEHIQEIVEQKTGIPVGKL QADEQTKMKELEAKLHERVIGQEAAVQKVAKAVRRSRAGLKSKNRPVGSFLFVGPTGV GKTELSKTLADELFGTKDAIIRLDMSEYMEKHAVSKIIGSPPGYVGHEEAGQLTEKVR RNPYSIVLLDEIEKAHPDVQHMFLQIMEDGRLTDSQGRTVSFKDTVIIMTSNAGAGEK QTKVGFQSDDSVIEEQTLIDSLSMFFKPEFLNRFDSIIEFRSLEKEHLVKIVSLLLGE LEETLAERGISLNVTDEAKEKIAELGYHPSFGARPLRRTIQEWVEDEMTDLLLDNGEI TSFHVILEDDKIKVRAK*" gene complement(1435628..1437727) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" downshifts complement(1435650) /Source="Nicolas_upshifts" /id="D758" /incds=0 /nref=27 /ntot=132 /MaxReadThrough="4.1802" /MaxDrop="6.07862" /score="41.2563375" /energy="-13.6" /TU="U1112" /idTUdmin="U1112" /TUdmin="-239" /isTUend="FALSE" S_feature complement(1437728..1437978) /Source="Nicolas_S_feature" /locus_tag="new_1437728_1437978_c" /HighExp="dia5, Heat, Diami, LPhT, dia15, H2O2, HiTm, S2, Cold, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.671" /TUlongSig="NA" /TUlongPSig="NA" /label="S492" promotor_no_box complement(1437938..1438038) /Source="Nicolas_upshift_promotors" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1437978) /Source="Nicolas_upshifts" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" promotor_-35 1438014..1438019 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1438029 /Source="Nicolas_upshifts" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" promotor_-10 1438035..1438053 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1438092..1439135 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389254.1" /db_xref="EnsemblGenomes-Gn:BSU13710" /db_xref="EnsemblGenomes-Tr:CAB13244" /db_xref="GOA:O31674" /db_xref="SubtiList:BG13311" /db_xref="UniProtKB/Swiss-Prot:O31674" /translation="MEQSKGSASQLAFVYVGTVVGAGFATGREIVEFFLKFGWFGFFG ILVSGGMFTLLGAKLMIISKRINAKSYQEMNIFLFGATAGRIINVFMLFVLLGVTSVM LSGAGALFEEQLGMSAQIGMLITIGLSLIVMTRGVKGIFGVNVFVVPLLIIFSMIVVA DSFIFSESRNAAQWVWPHRWDWLLSAVSYGALNLSLAQAVLVPLANEMSSEKVIKKGA LIGGTMLTIVLSASFLSLSTLPDVFLYDIPMAQVVYLFARSVHLIYLLIIFGEVFTSV IGNLYGLEKQVQSFLPVKSKYIFAAIMITAYITSQIGYGRLISTIYPLFGYVSLAFIG ALLCKKAPRRRSL*" gene 1438092..1439135 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" S_feature 1439136..1439227 /Source="Nicolas_S_feature" /locus_tag="new_1439136_1439227" /HighExp="S3, LoTm, S4, S5, BT, M9-stat, S6, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S493" promotor_-35 1439204..1439208 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1439225..1439244 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1439229 /Source="Nicolas_upshifts" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" misc_RNA 1439274..1439318 /gene="qswA" /locus_tag="BSU_misc_RNA_22" /product="preQ1 riboswitch" /experiment="publication(s) with functional evidences, PMID:17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311; Product type n: RNA" /function="16.3: Control" gene 1439274..1439318 /gene="qswA" /locus_tag="BSU_misc_RNA_22" downshifts 1439295 /Source="Nicolas_upshifts" /id="D759" /incds=0 /nref=11 /ntot=17 /MaxReadThrough="7.29177" /MaxDrop="4.09959" /score="21.1398563" /energy="-9.5" /TU="U1114" /idTUdmin="U1113" /TUdmin=0 /isTUend="TRUE" S_feature 1439340..1439447 /Source="Nicolas_S_feature" /locus_tag="new_1439340_1439447" /HighExp="Paraq, ferm, G180, LBGstat, Diami, H2O2, LPhT, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S494" CDS 1439448..1440107 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" /EC_number="6.3.4.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14660578, 16199558, 17384645, 18491386, 19354300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14660578, 16199558, 17384645, 18491386, 19354300; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pre-queuosine 0 synthase" /protein_id="NP_389255.1" /db_xref="EnsemblGenomes-Gn:BSU13720" /db_xref="EnsemblGenomes-Tr:CAB13245" /db_xref="GOA:O31675" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018317" /db_xref="PDB:3BL5" /db_xref="SubtiList:BG13312" /db_xref="UniProtKB/Swiss-Prot:O31675" /translation="MKKEKAIVVFSGGQDSTTCLLWALKEFEEVETVTFHYNQRHSQE VEVAKSIAEKLGVKNHLLDMSLLNQLAPNALTRNDIEIEVKDGELPSTFVPGRNLVFL SFASILAYQIGARHIITGVCETDFSGYPDCRDEFVKSCNVTVNLAMEKPFVIHTPLMW LNKAETWKLADELGALDFVKNNTLTCYNGIIADGCGECPACHLRSKGYEEYMVMKGER A*" gene 1439448..1440107 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" CDS 1440100..1440549 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" /EC_number="4.1.2.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 18259064, 19231875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 18259064, 19231875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-carboxy-5,6,7,8-tetrahydropterin synthase; queuosine biosynthesis" /protein_id="NP_389256.1" /db_xref="EnsemblGenomes-Gn:BSU13730" /db_xref="EnsemblGenomes-Tr:CAB13246" /db_xref="GOA:O31676" /db_xref="InterPro:IPR007115" /db_xref="SubtiList:BG13313" /db_xref="UniProtKB/Swiss-Prot:O31676" /translation="MHKLLSQIYPQAQHPYSFELNKDMHISAAHFIPRESAGACSRVH GHTYTVNITVAGDELDDSGFLVNFSVLKKLVHGNYDHTLLNDHEDFSQDDRYSLPTTE VVAKTIYDNVQAYLDTLENKPTCVQVFVRETPTSYCVYRPKKGGLNG*" gene 1440100..1440549 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" CDS 1440542..1441273 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" /EC_number="4.3.99.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 19354300, 23194065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 19354300, 23194065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-carboxy-7-deazaguanine synthase" /protein_id="NP_389257.1" /db_xref="EnsemblGenomes-Gn:BSU13740" /db_xref="EnsemblGenomes-Tr:CAB13247" /db_xref="GOA:O31677" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR017742" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR024924" /db_xref="PDB:5TGS" /db_xref="PDB:5TH5" /db_xref="SubtiList:BG13314" /db_xref="UniProtKB/Swiss-Prot:O31677" /translation="MAKGIPVLEIFGPTIQGEGMVIGQKTMFVRTAGCDYSCSWCDSA FTWDGSAKKDIRWMTAEEIFAELKDIGGDAFSHVTISGGNPALLKQLDAFIELLKENN IRAALETQGTVYQDWFTLIDDLTISPKPPSSKMVTNFQKLDHILTSLQENDRQHAVSL KVVIFNDEDLEFAKTVHKRYPGIPFYLQVGNDDVHTTDDQSLIAHLLGKYEALVDKVA VDAELNLVRVLPQLHTLLWGNKRGV*" gene 1440542..1441273 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" CDS 1441291..1441788 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" /EC_number="1.7.1.13" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent 7-cyano-7-deazaguanine reductase" /protein_id="NP_389258.1" /db_xref="EnsemblGenomes-Gn:BSU13750" /db_xref="EnsemblGenomes-Tr:CAB13248" /db_xref="GOA:O31678" /db_xref="InterPro:IPR016856" /db_xref="InterPro:IPR029500" /db_xref="PDB:4F8B" /db_xref="PDB:4FGC" /db_xref="PDB:5UDG" /db_xref="SubtiList:BG13315" /db_xref="UniProtKB/Swiss-Prot:O31678" /translation="MTTRKESELEGVTLLGNQGTNYLFEYAPDVLESFPNKHVNRDYF VKFNCPEFTSLCPKTGQPDFATIYISYIPDEKMVESKSLKLYLFSFRNHGDFHEDCMN IIMNDLIELMDPRYIEVWGKFTPRGGISIDPYTNYGKPGTKYEKMAEYRMMNHDLYPE TIDNR*" gene 1441291..1441788 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" S_feature 1441789..1442065 /Source="Nicolas_S_feature" /locus_tag="new_1441789_1442065" /HighExp="Paraq, ferm, LPhT, C30, G135, G180, LBGstat, Oxctl, G150, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S495" downshifts 1442023 /Source="Nicolas_upshifts" /id="D760" /incds=0 /nref=200 /ntot=247 /MaxReadThrough="1.17154" /MaxDrop="6.60953" /score="11.1883045" /energy="-7.8" /TU="NA" /idTUdmin="U1114" /TUdmin=0 /isTUend="TRUE" downshifts complement(1442033) /Source="Nicolas_upshifts" /id="D761" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.54726" /MaxDrop="2.16508" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=110 /isTUend="FALSE" S_feature complement(1442102..1442346) /Source="Nicolas_S_feature" /locus_tag="new_1442102_1442346_c" /HighExp="Diami, dia5, LPhT, Etha, Salt, dia15, Heat, HiTm, C30, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15795400000000001" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S496" downshifts complement(1442143) /Source="Nicolas_upshifts" /id="D762" /incds=0 /nref=47 /ntot=193 /MaxReadThrough="2.13712" /MaxDrop="5.08206" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=0 /isTUend="TRUE" CDS complement(1442347..1442703) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HGT island)" /protein_id="NP_389259.1" /db_xref="EnsemblGenomes-Gn:BSU13760" /db_xref="EnsemblGenomes-Tr:CAB13249" /db_xref="GOA:O31679" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13316" /db_xref="UniProtKB/Swiss-Prot:O31679" /translation="MKKFSCGFEVTKEVIGGKWKGLVLYFLMNGPKRTSELKRIIPNI TQKMLIQTLRELEASGLVSRKMYNQVPPKVEYSSTELGESLKPILQELCQWGGYYAEQ EYAEGEYEIVQPEQLS*" gene complement(1442347..1442703) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" misc_feature complement(1442734..1442753) /Source="Nicolas_upshift_promotors" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1442751) /Source="Nicolas_upshifts" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" promotor_-35 1442769 /Source="Nicolas_upshift_promotors" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1442788..1442806 /Source="Nicolas_upshift_promotors" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1442793 /Source="Nicolas_upshifts" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" CDS 1442872..1443618 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018, 26494135; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (HGT island)" /protein_id="NP_389260.1" /db_xref="EnsemblGenomes-Gn:BSU13770" /db_xref="EnsemblGenomes-Tr:CAB13250" /db_xref="GOA:O31680" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13317" /db_xref="UniProtKB/Swiss-Prot:O31680" /translation="MGKFEGKIALVTGGTSGIGLATAQKFVNEGAYVYITGRRQNELD KAVNQIGKNVTGVQGDISKLEDLDKLYDIIKQEKGKLDILFANAGIGNFLPLGEITEE QVDRTFDINVKGTIFTVQKALSLFPDKVGSIIVTGSTAGSIGNPAFSVYGASKAALRA LVRNWILDLKGTEIRVNVVSPGGILTPAYDELFGDALEEVLENSRNTVPAGKVGTPEE VANAVSFLASDESSYLTGVELFVDGGLAQV*" gene 1442872..1443618 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" downshifts 1443673 /Source="Nicolas_upshifts" /id="D763" /incds=0 /nref=19 /ntot=146 /MaxReadThrough="0.723690000000001" /MaxDrop="4.37163" /score="1.34631843" /energy="-9.1" /TU="NA" /idTUdmin="U1116" /TUdmin=0 /isTUend="TRUE" promotor_-35 1444021..1444029 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1444043..1444062 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1444047 /Source="Nicolas_upshifts" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" CDS 1444099..1445298 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11011148, 16683018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16683018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein (HGT island)" /protein_id="NP_389261.1" /db_xref="EnsemblGenomes-Gn:BSU13780" /db_xref="EnsemblGenomes-Tr:CAB13251" /db_xref="GOA:O31681" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13318" /db_xref="UniProtKB/Swiss-Prot:O31681" /translation="MKILFLESHPMWLYGLPNGFREAGHTVMISGPVSRENITEMIDE FKPDLIVSMGWTPEHSREKQAWIRNATKKVNIPLVYWATEDPLHTQNFTIPLIKKMKP DFVFTVTPSLCKTYESMGIKAAHLDFAFHESIHHQIKPLAKYSCDIAVVANAYPNFLE EHPEVFRSSSLKTLIRPLIRKGIRIDFWGRNWEKMSKYIGREIPRNWIHGYLDYTEAY KVYSSAKIIIGLQNCESQLTQRTYEILGSGGFLLTSDTPAVRGKFKPGRDLIVSSSPK ETLEKVKYYLNHDSERKKIQINGKKAVKNDSYRHRAERMLEVLKSRGIIRNLGETIHY VDVLKEKYVIHHVTPGETLSIIASKYNVSLQQLMELNHFKSDQIYAGQIIKIREKLFR NINNKLF*" gene 1444099..1445298 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" promotor_-35 1444181..1444187 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1444202..1444220 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1444208 /Source="Nicolas_upshifts" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" promotor_-35 1445267..1445269 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1445289..1445307 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1445301 /Source="Nicolas_upshifts" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" CDS 1445314..1445541 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative peptidoglycan binding protein" /protein_id="YP_003097719.1" /db_xref="EnsemblGenomes-Gn:BSU13789" /db_xref="EnsemblGenomes-Tr:CAX52610" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="UniProtKB/Swiss-Prot:C0H403" /translation="MKGKIPKIRNQANKVKRTPRYMEFPVTYEVYHVESGDTLWTIAK SFEIPVQQLMNLNKLSSDRIYPGQIIKIRER*" gene 1445314..1445541 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" misc_feature complement(1445391..1445410) /Source="Nicolas_upshift_promotors" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1445399) /Source="Nicolas_upshifts" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature 1445542..1445637 /Source="Nicolas_S_feature" /locus_tag="new_1445542_1445637" /HighExp="BT, S8, B36, S7, Etha, S6, G/S, LBGstat, Pyr, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigK" /TUshortPSig="0.602, 0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S497" CDS 1445638..1446336 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /EC_number="3.2.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative sporulation-specific glycosylase (HGT island)" /db_xref="EnsemblGenomes-Gn:BSU13790" /db_xref="EnsemblGenomes-Tr:CAB13252" /db_xref="GOA:O31682" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAB13252.1" /db_xref="SubtiList:BG13319" /db_xref="UniProtKB/Swiss-Prot:O31682" /translation="MFQMSYYYSGLGWDFIQHVDQTNGVLNVVSPDFFYIRKDGSLLL RSANPDVIKALHRRKLKVVPFLSNHWDQDLGRFALMNRVLLAKQISHAIEELDLDGVN IDIENLTEKDRNLFTDFIRLVRKSIPRHKEVSVAVAANPFGWTKGWHGSYDYEYLAKY ADYLMVMAYDESRLAGPTASVGWVEKSIQYVLTQKISPQKLVLGLPFYGRCWMEGQSA SQAIPLYLVVSKKA*" gene 1445638..1446336 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /pseudo S_feature complement(1446289..1447115) /Source="Nicolas_S_feature" /locus_tag="new_1446289_1447115_c" /HighExp="H2O2, M40t90, S8, M40t45, LPhT, Sw, Cold, LBGstat, C30, dia15" /AntisenseName="ykzR" /AntisenseCor="0.170402182980955" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="0.38670900000000002" /TUshortSig="SigA" /TUshortPSig="0.986" /TUlongSig="NA" /TUlongPSig="NA" /label="S498" CDS 1446317..1446568 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative spore-specific glycosyl hydrolase" /db_xref="EnsemblGenomes-Gn:BSU13799" /db_xref="EnsemblGenomes-Tr:CAX52611" /db_xref="GOA:C0H404" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAX52611.1" /db_xref="UniProtKB/Swiss-Prot:C0H404" /translation="MLVKRHSGTIIFDTKSQSPKAIFTVNHDKKGPLPSGTYTLWFEN EQSLRAKIKLAQKYNLKGLGSWSLGQEDASVWNTVFKNI*" gene 1446317..1446568 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /pseudo misc_feature 1446818..1446833 /Source="Nicolas_upshift_promotors" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1446841..1447052 /Source="Nicolas_S_feature" /locus_tag="new_1446841_1447052" /HighExp="Diami, S8, dia15, G180, HPh, C30, Paraq, H2O2, Salt, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.516" /TUlongSig="NA" /TUlongPSig="NA" /label="S499" upshifts 1446841 /Source="Nicolas_upshifts" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" downshifts 1447017 /Source="Nicolas_upshifts" /id="D764" /incds=0 /nref=2 /ntot=72 /MaxReadThrough="2.59168" /MaxDrop="2.74537" /score="-4.38958816" /energy="-9" /TU="NA" /idTUdmin="U1121" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1447104..1447123) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1447126) /Source="Nicolas_upshifts" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" promotor_-35 complement(1447139..1447146) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1447191..1447198 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1447213..1447232 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1447215 /Source="Nicolas_upshifts" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" CDS 1447251..1447541 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="NP_389263.1" /db_xref="EnsemblGenomes-Gn:BSU13800" /db_xref="EnsemblGenomes-Tr:CAB13253" /db_xref="InterPro:IPR021596" /db_xref="InterPro:IPR023105" /db_xref="PDB:2JN9" /db_xref="SubtiList:BG13320" /db_xref="UniProtKB/Swiss-Prot:O31683" /translation="MKTLRLNNVTLEMAAYQEESEPKRKIAFTLNVTSETYHDIAVLL YEKTFNVEVPERDLAFRGEMTNYSTSLTNLYEPGAVSEFYIEITEIDKNADS*" gene 1447251..1447541 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" S_feature complement(1447578..1447661) /Source="Nicolas_S_feature" /locus_tag="new_1447578_1447661_c" /HighExp="Etha, dia5, Salt, SMMPr, Lbtran, dia15, Heat, S4, HiOs, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S500" downshifts complement(1447621) /Source="Nicolas_upshifts" /id="D765" /incds=0 /nref=216 /ntot=257 /MaxReadThrough="2.80569" /MaxDrop="6.83857" /score="21.3524751" /energy="-9.9" /TU="U1124" /idTUdmin="U1126" /TUdmin=0 /isTUend="TRUE" CDS complement(1447662..1447847) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (HGT island)" /protein_id="NP_389264.2" /db_xref="EnsemblGenomes-Gn:BSU13810" /db_xref="EnsemblGenomes-Tr:CAB13254" /db_xref="InterPro:IPR018690" /db_xref="SubtiList:BG13321" /db_xref="UniProtKB/Swiss-Prot:O31684" /translation="MKIAKVGNVIEFKNGLTGVVEKVNENSVIVDVTIMDNYRDLELD SLTVVNHKNYKIIRDSY*" gene complement(1447662..1447847) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" promotor_-10 complement(1447880..1447899) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1447891) /Source="Nicolas_upshifts" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" S_feature complement(1447893..1448237) /Source="Nicolas_S_feature" /locus_tag="new_1447893_1448237_c" /HighExp="S4, S8, S6, S5, S3, T5.0H, LoTm, S7, T4.0H, BT" /AntisenseName="ykzS" /AntisenseCor="-0.65556958045860303" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S501" promotor_-35 complement(1447913..1447920) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1447946..1447951 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1447967..1447986 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1447974 /Source="Nicolas_upshifts" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" CDS 1448013..1448207 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="YP_003097721.1" /db_xref="EnsemblGenomes-Gn:BSU13819" /db_xref="EnsemblGenomes-Tr:CAX52612" /db_xref="UniProtKB/Swiss-Prot:C0H405" /translation="MRPEEITEMIEQLRTGAINELRVQKEHFLDFRAVLSKQDDFKHF RGIAQQGGDVIFQYLEQPRS*" gene 1448013..1448207 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" downshifts 1448183 /Source="Nicolas_upshifts" /id="D766" /incds=0 /nref=6 /ntot=124 /MaxReadThrough="3.66738" /MaxDrop="3.03929" /score="5.82604583" /energy="-10.6" /TU="U1125" /idTUdmin="U1123" /TUdmin=682 /isTUend="FALSE" promotor_-10 complement(1448228..1448246) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1448244) /Source="Nicolas_upshifts" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" promotor_-35 complement(1448263..1448268) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1448506..1449132 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12177332, 12950927, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall hydrolase related to spore cortex-lytic enzymes" /protein_id="NP_389265.1" /db_xref="EnsemblGenomes-Gn:BSU13820" /db_xref="EnsemblGenomes-Tr:CAB13255" /db_xref="GOA:O31685" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG13322" /db_xref="UniProtKB/Swiss-Prot:O31685" /translation="MTTKFTALAVFLLCFMPAAKIEHTQASLLSAKKTKHEEAKWLTH IDRNTNESFPSLSADKDKKIKPIKLSAHTEKKEKDKPDKTNDEKETYTQSEKELLSRL VHAEAKGESYKGKVAVASVVLNRTEKKGFPDTIRGVIYQKNAFEPVANGSINQKPDKE SIEAAEEALSSKNRETDAIFFYNPKTASDNWIRSRKIVEKIGRHVFAV*" gene 1448506..1449132 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" downshifts 1449063 /Source="Nicolas_upshifts" /id="D767" /incds=1 /nref=1 /ntot=17 /MaxReadThrough="0.932830000000001" /MaxDrop="1.92264" /score="9.80914166" /energy="-11.9" /TU="NA" /idTUdmin="U1125" /TUdmin=44 /isTUend="FALSE" promotor_-35 1449189..1449194 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1449201 /Source="Nicolas_upshifts" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" promotor_-10 1449210..1449228 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1449250..1450587 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15686839, 15849754, 16850406, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15686839, 15849754, 16850406, 19648239; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore membrane protein involved in germination" /protein_id="NP_389266.1" /db_xref="EnsemblGenomes-Gn:BSU13830" /db_xref="EnsemblGenomes-Tr:CAB13256" /db_xref="GOA:O31686" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="SubtiList:BG13323" /db_xref="UniProtKB/Swiss-Prot:O31686" /translation="MNRFVKGIILLSIAAFFAECLEFVVNMILARELGEHGMGLYMSI LPTIFLIIVIASLELPISISKFIAESNPKLHESMLRHAFRMTAIFTAFSTAAASIALP FIPVFDTYHPFIKGIVIGLIPVVAFTSIARGYFMGVQKMGKIAIANVLKKIIQLLCLF LFFQWYSFELDMAVLISLFVLVVSDVVVLVYLYSQFIMARRALSGQQHIHLRGKDVRK RLLAVSIPTTGLRIFHAVVNAIEPFLVKGALLAAGVAGTAAIDQYGMLAGVAVTIGSF PAFIAHSLMVVMIPSISEAYALSQYDIVLKRLKQSIFITLGYGIPAVWVMFQFAGPLT HLFFHSPEAQYYLQLLWPYFLFHLFVMPLQACLIGMGFVKEAFYHNVWSHIVALSMMY VLGSMENLQMLGIILGMNTGMILLTSLHYATICKALKVSVFLTGGTRTPRIEG*" gene 1449250..1450587 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" CDS 1450638..1451135 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15292147, 15322369, 15342593, 19144642, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292147, 15322369, 15342593, 19144642, 28383125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific thiol-disulfide oxidoreductase (SpoVD maturation)" /protein_id="NP_389267.1" /db_xref="EnsemblGenomes-Gn:BSU13840" /db_xref="EnsemblGenomes-Tr:CAB13257" /db_xref="GOA:O31687" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:3ERW" /db_xref="SubtiList:BG13324" /db_xref="UniProtKB/Swiss-Prot:O31687" /translation="MLTKRLLTIYIMLLGLIAWFPGAAQAEEKQPAVPAVFLMKTIEG EDISIPNKGQKTILHFWTSWCPPCKKELPQFQSFYDAHPSDSVKLVTVNLVNSEQNQQ VVEDFIKANKLTFPIVLDSKGELMKEYHIITIPTSFLLNEKGEIEKTKIGPMTAEQLK EWTEE*" gene 1450638..1451135 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" promotor_-35 1450984..1450990 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1450999 /Source="Nicolas_upshifts" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 1451005..1451023 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1451109 /Source="Nicolas_upshifts" /id="D768" /incds=0 /nref=36 /ntot=164 /MaxReadThrough="1.89069" /MaxDrop="4.34947" /score="14.1388498" /energy="-11.3" /TU="NA" /idTUdmin="U1127" /TUdmin=0 /isTUend="TRUE" promotor_-35 1451230..1451236 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1451247..1451266 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1451259 /Source="Nicolas_upshifts" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" S_feature 1451263..1451370 /Source="Nicolas_S_feature" /locus_tag="new_1451263_1451370" /HighExp="LBGstat, C90, Lbstat, BC, Cold, T0.30H, Etha, Lbtran, LBGtran, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S502" CDS 1451371..1453284 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029044, 12180919, 15802251, 21813502, 26261021, 26566138" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12180919, 15802251, 21813502, 26261021, 26566138; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Fe(II) efflux transporter possibly involved in copper(II) uptake" /protein_id="NP_389268.1" /db_xref="EnsemblGenomes-Gn:BSU13850" /db_xref="EnsemblGenomes-Tr:CAB13258" /db_xref="GOA:O31688" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13325" /db_xref="UniProtKB/Swiss-Prot:O31688" /translation="MNEQVIVQRDPHEPLKTDKREKNWAQHAELIAALVSGALILAGW LLSGYQVLSIILFLLAFVIGGFAKAKEGIEETLESKTLNVELLMIFAAIGSALIGYWA EGAILIFIFSLSGALETYTMNKSSRDLTSLMQLEPEEATLMVNGETKRVPVSDLQAGD MIVIKPGERVAADGIIESGSTSLDESALTGESMPVEKNTGDTVFTGTVNRNGSLTVRV TKANEDSLFRKIIKLVESAQNSVSPAQAFIERFENAYVKGVLIAVALLLFVPHFALGW SWSETFYRAMVFMVVASPCALVASIMPAALSLISNGARNGMLVKGSVFLEQLGSVQMI AFDKTGTVTKGQPAVETIRIAEGFSEAEVLEAVYAIETQSSHPLAQAITAYAESRGVN QSGYISIEETSGFGVMAEVSGAKWKVGKAGFIGEEMAAQFMKQTASDVIQSGHTIVFV KKDDQIAGCIALKDQIRPEAKEVMEELNRLGIKTAMLTGDHEDTAQAIAKEAGMTTVV AECLPDQKVNEIKRLKEEFGTIAMVGDGINDAPALKAADVGIAMGGGTDVALETADMV LMKNDLKKLVNMCRLSRKMNRIIKQNIVFSLAVICLLICANFLQAMELPFGVIGHEGS TILVILNGLRLLK*" gene 1451371..1453284 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" promotor_-10 complement(1451520..1451539) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1451537) /Source="Nicolas_upshifts" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1451552..1451561) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1451688..1451707) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1451713) /Source="Nicolas_upshifts" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1451721..1451727) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1453265 /Source="Nicolas_upshifts" /id="D769" /incds=0 /nref=62 /ntot=148 /MaxReadThrough="2.05978" /MaxDrop="6.90668" /score="30.2111295" /energy="-18" /TU="NA" /idTUdmin="U1129" /TUdmin=0 /isTUend="TRUE" downshifts complement(1453341) /Source="Nicolas_upshifts" /id="D770" /incds=0 /nref=74 /ntot=208 /MaxReadThrough="0.83751" /MaxDrop="4.23141" /score="34.2342147" /energy="-18" /TU="NA" /idTUdmin="U1132" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1453552..1453571) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1453561) /Source="Nicolas_upshifts" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1453585..1453592) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1453636..1453655 /Source="Nicolas_upshift_promotors" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1453646 /Source="Nicolas_upshifts" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" CDS 1453691..1454782 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7770058, 23144141" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7770058, 23144141; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Xaa-Pro Xaa-Pro-Xaa di-tri-peptidase used in osmoprotection" /protein_id="NP_389269.1" /db_xref="EnsemblGenomes-Gn:BSU13860" /db_xref="EnsemblGenomes-Tr:CAB13259" /db_xref="GOA:O31689" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG13326" /db_xref="UniProtKB/Swiss-Prot:O31689" /translation="MNRIQRVSSWLKEAGHTAAFIHTKENVFYLTGFYTEPHERLMGL FIFQEEEPFFVCPGMEAGQARNAGWNHEIIGYADHENPWELIEKALKKRNISIHMLAV EKDSISLSRAEQLKHATGGAQFVSAEETLNQFRLIKDDNEIRLLKEAAKLADYGVEVG TAALREGISEVEVLAQIEYELKKKGIQGMSFSTMVLFGEKSGQPHGNPGTATLKKGDF VLFDLGVILDGYCSDITRTFAYKTINPKQEAIYETVLQAEKAAIEASKPGVRIGDLDL TARGIIEKAGYGDYFPHRLGHGLGISVHEYPSMSQANDTLLQEGMVYTIEPGIYVPEI GGVRIEDDVHVTKDGAVALTQYPKDLIIL*" gene 1453691..1454782 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" downshifts 1454431 /Source="Nicolas_upshifts" /id="D771" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.10599" /MaxDrop="5.06339" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1166 /isTUend="FALSE" downshifts 1454761 /Source="Nicolas_upshifts" /id="D772" /incds=0 /nref=2 /ntot=52 /MaxReadThrough="5.66039" /MaxDrop="2.56719" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1496 /isTUend="FALSE" S_feature complement(1454795..1455013) /Source="Nicolas_S_feature" /locus_tag="new_1454795_1455013_c" /HighExp="B60, B36, C30, G135, LBGstat, S8, Lbstat, C90, Etha, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.92748200000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S503" S_feature 1454806..1455063 /Source="Nicolas_S_feature" /locus_tag="new_1454806_1455063" /HighExp="dia15, dia5, Etha, M0t90, M40t90, Lbstat, H2O2, G150, Mt0, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S504" promotor_-10 complement(1455000..1455019) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1455013) /Source="Nicolas_upshifts" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" promotor_-35 complement(1455035..1455042) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1455064..1456029 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LacI family)" /protein_id="NP_389270.1" /db_xref="EnsemblGenomes-Gn:BSU13870" /db_xref="EnsemblGenomes-Tr:CAB13260" /db_xref="GOA:O31690" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13327" /db_xref="UniProtKB/Swiss-Prot:O31690" /translation="MANIKDIAEKAGVSVTTVSRVINNHPYVSEDKRKRVFEAMESLE YTRNIHAVHLSKGFSNMIGVVLPTVNLPYFAELIAGIADAAAESGVHLSLFQTNYEVQ KEIFALSQLKQRQVDGLIFCSKALADEKLMEWEGPILLCQNSDNARFPTISIPHQEAF RNGLDYLIAKGHKKIAICLARKKGMNSHFRIKAYKEALEEIGEAFREDWVIEKAITIN DGKALFHKWNTWKEKPTAIFVANDQVSAGLFLEAKNQRVSVPDELAILSVDNHEISQA LGITTIDIQTREMGKQAFAILEKRIQGQPIERKVLDYRLIERSTV*" gene 1455064..1456029 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" promotor_-35 1456047..1456054 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-35" promotor_-10 1456069..1456088 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-10" upshifts 1456081 /Source="Nicolas_upshifts" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" CDS 1456092..1456958 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10974121, 14527945, 15155854, 17074746, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974121, 14527945, 15155854, 17074746, 22750856; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_389271.2" /db_xref="EnsemblGenomes-Gn:BSU13880" /db_xref="EnsemblGenomes-Tr:CAB13261" /db_xref="GOA:O31691" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:3GWH" /db_xref="PDB:3RIO" /db_xref="PDB:3UFE" /db_xref="SubtiList:BG12593" /db_xref="UniProtKB/Swiss-Prot:O31691" /translation="MTKELRIVNGSFTVKKVLNNNVLIASHHKYSEVVLIGKGIGFGK KQDDVIEDKGYDKMFILKDEKEQKQFKKLLDYVDEKLVDISNDVIYHISNRTNHSLNE HIHIALTDHIAFAIKRQQQGFDMKNPFLMETQSLYPEEYQIAKEVIDMINEKAGLCLP EGEIGFIALHIHSALTNRPLSEVNQHSQLMAQLVEVIEDSFQMKVNKESVNYLRLIRH IRFTIERIKKEEPTKEPEKLMLLLKNEYPLCYNTAWKLIKILQQTLKKPVHEAEAVYL TLHLYRLTNKIS*" gene 1456092..1456958 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" promotor_-35 1456813..1456817 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1456834..1456853 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1456842 /Source="Nicolas_upshifts" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" downshifts 1456960 /Source="Nicolas_upshifts" /id="D773" /incds=0 /nref=1 /ntot=30 /MaxReadThrough="9.01653" /MaxDrop="3.09921" /score="-5.18621526" /energy="-6.2" /TU="U1133,U1135,U1136" /idTUdmin="U1135" /TUdmin="-220" /isTUend="FALSE" misc_RNA 1457005..1457156 /gene="gswA" /locus_tag="BSU_misc_RNA_88" /product="riboswitch regulating ptsGHI expression via GlcTbinding" /experiment="publication(s) with functional evidences, PMID:15155854, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15155854, 22750856; Product type n: RNA" S_feature 1457005..1457156 /Source="Nicolas_S_feature" /locus_tag="new_1457005_1457156" /HighExp="LBGexp, G150, C30, G135, G180, MG 90, dia0, Lbexp, dia15, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.988, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S505" gene 1457005..1457156 /gene="gswA" /locus_tag="BSU_misc_RNA_88" promotor_-35 1457134..1457140 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1457154..1457165 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1457158 /Source="Nicolas_upshifts" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" CDS 1457187..1459286 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" /EC_number="2.7.1.199" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucose-specificenzyme IICBA component" /protein_id="NP_389272.1" /db_xref="EnsemblGenomes-Gn:BSU13890" /db_xref="EnsemblGenomes-Tr:CAB13262" /db_xref="GOA:P20166" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="PDB:1AX3" /db_xref="PDB:1GPR" /db_xref="SubtiList:BG10198" /db_xref="UniProtKB/Swiss-Prot:P20166" /translation="MFKALFGVLQKIGRALMLPVAILPAAGILLAIGNAMQNKDMIQV LHFLSNDNVQLVAGVMESAGQIVFDNLPLLFAVGVAIGLANGDGVAGIAAIIGYLVMN VSMSAVLLANGTIPSDSVERAKFFTENHPAYVNMLGIPTLATGVFGGIIVGVLAALLF NRFYTIELPQYLGFFAGKRFVPIVTSISALILGLIMLVIWPPIQHGLNAFSTGLVEAN PTLAAFIFGVIERSLIPFGLHHIFYSPFWYEFFSYKSAAGEIIRGDQRIFMAQIKDGV QLTAGTFMTGKYPFMMFGLPAAALAIYHEAKPQNKKLVAGIMGSAALTSFLTGITEPL EFSFLFVAPVLFAIHCLFAGLSFMVMQLLNVKIGMTFSGGLIDYFLFGILPNRTAWWL VIPVGLGLAVIYYFGFRFAIRKFNLKTPGREDAAEETAAPGKTGEAGDLPYEILQAMG DQENIKHLDACITRLRVTVNDQKKVDKDRLKQLGASGVLEVGNNIQAIFGPRSDGLKT QMQDIIAGRKPRPEPKTSAQEEVGQQVEEVIAEPLQNEIGEEVFVSPITGEIHPITDV PDQVFSGKMMGDGFAILPSEGIVVSPVRGKILNVFPTKHAIGLQSDGGREILIHFGID TVSLKGEGFTSFVSEGDRVEPGQKLLEVDLDAVKPNVPSLMTPIVFTNLAEGETVSIK ASGSVNREQEDIVKIEK*" gene 1457187..1459286 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" promotor_-35 1459304..1459308 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1459324..1459343 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1459335 /Source="Nicolas_upshifts" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" CDS 1459384..1459650 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="histidine-containing phosphocarrier protein of the phosphotransferase system (PTS) (HPr protein)" /protein_id="NP_389273.1" /db_xref="EnsemblGenomes-Gn:BSU13900" /db_xref="EnsemblGenomes-Tr:CAB13263" /db_xref="GOA:P08877" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR001020" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1JEM" /db_xref="PDB:1KKL" /db_xref="PDB:1KKM" /db_xref="PDB:1SPH" /db_xref="PDB:2FEP" /db_xref="PDB:2HID" /db_xref="PDB:2HPR" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10200" /db_xref="UniProtKB/Swiss-Prot:P08877" /translation="MAQKTFKVTADSGIHARPATVLVQTASKYDADVNLEYNGKTVNL KSIMGVMSLGIAKGAEITISASGADENDALNALEETMKSEGLGE*" gene 1459384..1459650 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" CDS 1459650..1461362 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" /EC_number="2.7.3.9" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106335, 11902727, 15155854, 15670601, 25355936, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106335, 11902727, 15155854, 15670601, 25355936, 26159071; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) enzyme I" /protein_id="NP_389274.2" /db_xref="EnsemblGenomes-Gn:BSU13910" /db_xref="EnsemblGenomes-Tr:CAB13264" /db_xref="GOA:P08838" /db_xref="InterPro:IPR000121" /db_xref="InterPro:IPR006318" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR008731" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018274" /db_xref="InterPro:IPR023151" /db_xref="InterPro:IPR024692" /db_xref="InterPro:IPR036618" /db_xref="SubtiList:BG10201" /db_xref="UniProtKB/Swiss-Prot:P08838" /translation="MQELKGIGASAGIAIAKAYRLEEPDLTVEKKNISDSEAEVSRFD EAIARSKEELEKIKEHALKELGQDKADIFSAHLLVLSDPELLNPVKEKISTDSVNAEF ALKETSSMFVTMFESMDNEYMKERAADIRDVTKRVTGHLLGVEIPNPSMISEEVIIVA EDLTPSDTAQLNREFVKGFTTDIGGRTSHSAIMARSLEIPAVVGTKAATGTIQNGVTV IVDGINGDVIIDPSAETVKEYEEKHNAYLAQKAEWAKLVNEPTVSKDGHHVELAANIG TPDDVKGVLENGGEAVGLYRTEFLYMGRDQLPTEDEQFDAYKTVLERMEGKSVVVRTL DIGGDKELPYLQLPKEMNPFLGYRAIRLCLEEQEIFRTQLRALLRASTYGNLKIMFPM IATVNEFKEAKAILLEEKEKLVKAGQAVSDDIEVGMMVEIPSTAVIADQFAKEVDFFS IGTNDLIQYTMAADRMNERVSYLYQPYNPAILRLITLVIEAAHKEGKWVGMCGEMAGD EIAIPILLGLGLDEFSMSATSILPARTQISKLSKQEAESFKEKILSMSTTEEVVAFVK ETFK*" gene 1459650..1461362 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" downshifts 1461349 /Source="Nicolas_upshifts" /id="D774" /incds=0 /nref=116 /ntot=277 /MaxReadThrough="5.0255" /MaxDrop="5.64321" /score="21.2608168" /energy="-12.3" /TU="U1136,U1138" /idTUdmin="U1133" /TUdmin=11 /isTUend="TRUE" promotor_-35 1461402..1461408 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1461423..1461434 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1461426 /Source="Nicolas_upshifts" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" CDS 1461453..1461692 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9009064, 9323362, 10629212" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9009064, 9323362, 10629212; Product type r: regulator" /codon_start=1 /transl_table=11 /product="TRAP-like transcriptional negative regulator of spore photoproduct lyase" /protein_id="NP_389275.1" /db_xref="EnsemblGenomes-Gn:BSU13920" /db_xref="EnsemblGenomes-Tr:CAB13265" /db_xref="GOA:P37955" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG10202" /db_xref="UniProtKB/Swiss-Prot:P37955" /translation="MSNQFNAGDTVYVIYRNPHAANVAHIKEAEIVHHPYHEGELSLF IYETYHPFAEDDAVFASYEEAKSLYKELFDIDPYE*" gene 1461453..1461692 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" S_feature complement(1461473..1462812) /Source="Nicolas_S_feature" /locus_tag="new_1461473_1462812_c" /HighExp="T4.0H, T3.30H, T3.0H, S3, S1, T2.0H, T2.30H, S2, T5.0H, S4" /AntisenseName="splB" /AntisenseCor="-0.193138593783996" /AntisenseRegPval="-2.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S506" CDS 1461770..1462798 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" /EC_number="4.1.99.14" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore photoproduct (thymine dimer) lyase" /protein_id="NP_389276.1" /db_xref="EnsemblGenomes-Gn:BSU13930" /db_xref="EnsemblGenomes-Tr:CAB13266" /db_xref="GOA:P37956" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023897" /db_xref="InterPro:IPR034560" /db_xref="SubtiList:BG10203" /db_xref="UniProtKB/Swiss-Prot:P37956" /translation="MQNPFVPQLVYIEPRALEYPLGQELQDKFENMGIEIRETTSHNQ VRNIPGKNHLQQYRNAKSTLVIGVRKTLKFDSSKPSAEYAIPFATGCMGHCHYCYLQT TMGSKPYIRTYVNVEEILDQADKYMKERAPEFTRFEASCTSDIVGIDHLTHTLKRAIE HFGQSDLGKLRFVTKFHHVDHLLDAKHNGKTRFRFSINADYVIKNFEPGTSPLDKRIE AAVKVAKAGYPLGFIVAPIYIHEGWEEGYRHLFEKLDAALPQDVRHDITFELIQHRFT KPAKRVIEKNYPKTKLELDEEKRRYKWGRYGIGKYIYQKDEEHALREALESYIDTFFP NAKIEYFT*" gene 1461770..1462798 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" downshifts 1462768 /Source="Nicolas_upshifts" /id="D775" /incds=0 /nref=5 /ntot=113 /MaxReadThrough="0.352" /MaxDrop="3.95383" /score="15.9223136" /energy="-13.2" /TU="NA" /idTUdmin="U1136" /TUdmin=0 /isTUend="TRUE" CDS complement(1462813..1463493) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase / amidohydrolase" /protein_id="NP_389277.2" /db_xref="EnsemblGenomes-Gn:BSU13940" /db_xref="EnsemblGenomes-Tr:CAB13267" /db_xref="GOA:Q796K9" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12252" /db_xref="UniProtKB/Swiss-Prot:Q796K9" /translation="MIILKQMYVHDGRKFEALTIRNYTETDIERLISLQEECFPPPFP QELLWSEDQLASHIKTFPEGALCALINGRIIGSMTALIVQFEPDSPDHTWAQATDNGS IKNHEPHGNTLYVVDISVSPHYRKLGIGKWLMNTMYELTVDKRLERLLGGGRIPLYYK YAHEISAVQYVEDVMEGRKNDPVLSFLLRCGRSPIRVVSNYLEDKESLNYGVLMEWKN VFYKKASC*" gene complement(1462813..1463493) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" promotor_-10 complement(1463503..1463522) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1463526) /Source="Nicolas_upshifts" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" promotor_-35 complement(1463537..1463544) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1463578..1463585 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-35" promotor_-10 1463599..1463617 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-10" upshifts 1463605 /Source="Nicolas_upshifts" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" CDS 1463628..1465595 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9721285, 11722727, 12603740, 15317802, 23038252, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9721285, 11722727, 12603740, 15317802, 23038252, 27899502; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_389278.2" /db_xref="EnsemblGenomes-Gn:BSU13950" /db_xref="EnsemblGenomes-Tr:CAB13268" /db_xref="GOA:P54576" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG11533" /db_xref="UniProtKB/Swiss-Prot:P54576" /translation="MFKKLHMKIAVFVSIMLIITVVLLMLSSYLTLKPMITEDGKNTT QNVTQSLEQNIELQLKSYAISLSRLANGELTHTFVTKPSKEASRLFHDDIKQIKDNDD YVAMAYIGTAKKEMFTYPKADFAEDYDPTSRPWYKLAAETPDQVVWTEPYKDVVTGDM IVTASKAILDRQKVIGVASYDLKLSAIQSMVNKQKVPYKGFAFLADASGNLLAHPSNQ GKNISKDQTLQTIASEKKGIQDVNGKMVVYQTIGETGWKVGTQFDTDQLMWISDKMNR ANLWISLIALIITIILSYFLAKTITGPIQQLIVKTKAVSAGDLTVRAESKSKDEVGIL TRDFNLMVENMKEMVEQVRLSSGKVSDTSEQLTAVAAETNETSGQIAKAIEEVAAGAS EQASEVETINEKSESLSTKIRQIAEEAGGIKERSKSSEDASYKGLDALGQLLMKSNEA NMETKKVETMLLDLENQTKNIEEVVTAISNISDQTNLLALNASIEAARAGESGRGFAV VADEVRKLAEQSALSTKHISETVKLIQLETKEASHAMVEASRMNDEQNSAIHETGEVL NTITAEMQSLVQGIDHIYAEIQRMSEEQLAISEAIQSISAISQESAAAAEEVNASTDE QLVTLDKVKHSTETLKHASQELMNTIAKFTL*" gene 1463628..1465595 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" misc_feature complement(1464068..1464083) /Source="Nicolas_upshift_promotors" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1464080) /Source="Nicolas_upshifts" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1465566 /Source="Nicolas_upshifts" /id="D776" /incds=0 /nref=134 /ntot=209 /MaxReadThrough="3.05506" /MaxDrop="5.75836" /score="24.6367658" /energy="-12.1" /TU="U1141" /idTUdmin="U1141" /TUdmin="-89" /isTUend="FALSE" promotor_-35 1465639..1465641 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1465657..1465676 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1465667 /Source="Nicolas_upshifts" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" downshifts complement(1465709) /Source="Nicolas_upshifts" /id="D777" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="2.29647" /MaxDrop="4.49503" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=946 /isTUend="FALSE" CDS 1465733..1466599 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" /EC_number="1.1.1.60" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:20941576, 24390483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20941576, 24390483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacid dehydrogenase (acts on 3-hydroxypropionate with NADP)" /protein_id="NP_389279.1" /db_xref="EnsemblGenomes-Gn:BSU13960" /db_xref="EnsemblGenomes-Tr:CAB13269" /db_xref="GOA:O34948" /db_xref="InterPro:IPR002204" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13328" /db_xref="UniProtKB/Swiss-Prot:O34948" /translation="MKKTIGFIGLGVMGKSMASHILNDGHPVLVYTRTKEKAESILQK GAIWKDTVKDLSKEADVIITMVGYPSDVEEVYFGSNGIIENAKEGAYLIDMTTSKPSL AKKIAEAAKEKALFALDAPVSGGDIGAQNGTLAIMVGGEKEAFEACMPIFSLMGENIQ YQGPAGSGQHTKMCNQIAIAAGMIGVAEAMAYAQKSGLEPENVLKSITTGAAGSWSLS NLAPRMLQGNFEPGFYVKHFIKDMGIALEEAELMGEEMPGLSLAKSLYDKLAAQGEEN SGTQSIYKLWVK*" gene 1465733..1466599 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" downshifts 1466579 /Source="Nicolas_upshifts" /id="D778" /incds=0 /nref=239 /ntot=266 /MaxReadThrough="2.14032" /MaxDrop="8.18847" /score="41.1703019" /energy="-14.5" /TU="NA" /idTUdmin="U1143" /TUdmin=0 /isTUend="TRUE" CDS complement(1466638..1467411) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389280.2" /db_xref="EnsemblGenomes-Gn:BSU13970" /db_xref="EnsemblGenomes-Tr:CAB13270" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR014258" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13329" /db_xref="UniProtKB/Swiss-Prot:O31398" /translation="MKKAFILSAAAAVGLFTFGGVQQASAKELSCQPVVTVKTGNTVQ NMSLNDAVKKLHINTNIKTLNAANEKEMKQLLQKHAKQSNVKVQDVQKTETAKPAQKT TEKAAADQNTASKAPATAEKTNTTTSAPSSVSAYEKKVVELTNAERQKQGLKPLQIDE TLSKSARAKSQDMKDKNYFDHQSPTYGSPFDMMKSFGISYKTAGENIAKGQKTPEEVV KAWMNSEGHRKNILNPNFTHIGVGYVESGSIWTQQFIGK*" gene complement(1466638..1467411) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" downshifts complement(1466655) /Source="Nicolas_upshifts" /id="D779" /incds=0 /nref=31 /ntot=168 /MaxReadThrough="1.32532" /MaxDrop="5.28625" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=0 /isTUend="TRUE" misc_feature complement(1467443..1467462) /Source="Nicolas_upshift_promotors" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1467453) /Source="Nicolas_upshifts" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" misc_feature 1467686..1467705 /Source="Nicolas_upshift_promotors" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1467699 /Source="Nicolas_upshifts" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" S_feature 1467701..1467804 /Source="Nicolas_S_feature" /locus_tag="new_1467701_1467804" /HighExp="T4.0H, T3.30H, T3.0H, Etha, T5.0H, T2.30H, LoTm, B60, T2.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S507" CDS 1467748..1469862 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12896990, 23199363" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12896990, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding enzyme for formation of rod-shaped peptidoglycan cell wall" /protein_id="NP_389281.2" /db_xref="EnsemblGenomes-Gn:BSU13980" /db_xref="EnsemblGenomes-Tr:CAB13271" /db_xref="GOA:Q796K8" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13286" /db_xref="UniProtKB/Swiss-Prot:Q796K8" /translation="MTEIGREPKKKSKGNRAIRMNLFFLAVFVLFTALIFKLGVVQIV EGEQHEEDAEKSNAKTAYYPAPRGKMYDRNQKVAVDNQSVPEIVYVSTSSTKTEDKIK TAKRLASFIHIDTEFLKERDLRDYWIAAHPKKAAALLKESESNLKGDQAYKLQIERVP DQELKAIQQDDEEMETAAIYTRFSSGNAYEPQIVKAMNPNKSNSNGKNGALLDEKKNS SQRPKNDLTYDEISIVSEHLEELPGIDIVNDWTRKYPYDKTLYSVFGGVTTPDQGLLS DRKDFYLTRGYANNDRVGKSYLEYQYEEYLNSHKEKVEYVEDNKGNVVSQKTIDKGSR GYDLQLSFDMELQAKVEKIIEEEVRNSRARGNYMLDRAFAVMMDPNNGDILSMAGKKI DLKTNKIEDYAIGAFTTQYEMGSAVKGATVLAGYQDGIPHYKYYIDAPMLLGTNLIKK SYTNMGTINELTALQKSSNVYMFNVAMHIAGVTYKPHGSLPADQNDLLKMRNYYSQFG LGVKTGIDLPQESAGMQTTPKTVGGLILDLAIGQYDTYTPLQMAQYISVIANGGYRVQ PRIVTSIHKPGKKDQLGKAIEHRKPKVLNKINNSESDLKQVQTGMKLVTSSGTAKNTF TEDVSGKTGTAETFYYGTNRNWWGKKTYNLTFVGYYPSKKPKVAFSVVVPSVDDDDKI NKIIAKRAIHAYAELEKKHSKK*" gene 1467748..1469862 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" promotor_-10 complement(1469041..1469059) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1469053) /Source="Nicolas_upshifts" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1469075..1469080) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1469843 /Source="Nicolas_upshifts" /id="D780" /incds=0 /nref=139 /ntot=246 /MaxReadThrough="3.36066" /MaxDrop="5.01597" /score="-1.2500858" /energy="-12" /TU="U1145" /idTUdmin="U1145" /TUdmin="-1862" /isTUend="FALSE" promotor_-35 1469935..1469943 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1469955..1469973 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1469967 /Source="Nicolas_upshifts" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" CDS 1470026..1471846 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation-specific ATP-dependent protein histidine kinase" /protein_id="NP_389282.1" /db_xref="EnsemblGenomes-Gn:BSU13990" /db_xref="EnsemblGenomes-Tr:CAB13272" /db_xref="GOA:P16497" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013655" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:2VLG" /db_xref="SubtiList:BG10204" /db_xref="UniProtKB/Swiss-Prot:P16497" /translation="MEQDTQHVKPLQTKTDIHAVLASNGRIIYISANSKLHLGYLQGE MIGSFLKTFLHEEDQFLVESYFYNEHHLMPCTFRFIKKDHTIVWVEAAVEIVTTRAER TEREIILKMKVLEEETGHQSLNCEKHEIEPASPESTTYITDDYERLVENLPSPLCISV KGKIVYVNSAMLSMLGAKSKDAIIGKSSYEFIEEEYHDIVKNRIIRMQKGMEVGMIEQ TWKRLDGTPVHLEVKASPTVYKNQQAELLLLIDISSRKKFQTILQKSRERYQLLIQNS IDTIAVIHNGKWVFMNESGISLFEAATYEDLIGKNIYDQLHPCDHEDVKERIQNIAEQ KTESEIVKQSWFTFQNRVIYTEMVCIPTTFFGEAAVQVILRDISERKQTEELMLKSEK LSIAGQLAAGIAHEIRNPLTAIKGFLQLMKPTMEGNEHYFDIVFSELSRIELILSELL MLAKPQQNAVKEYLNLKKLIGEVSALLETQANLNGIFIRTSYEKDSIYINGDQNQLKQ VFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTKE KGTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFPKK*" gene 1470026..1471846 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" CDS complement(1471857..1473038) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" /EC_number="2.6.1.83" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 14523133, 14627808, 19948795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 14523133, 14627808, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-L,L-diaminopimelate aminotransferase" /protein_id="NP_389283.2" /db_xref="EnsemblGenomes-Gn:BSU14000" /db_xref="EnsemblGenomes-Tr:CAB13273" /db_xref="GOA:P16524" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10205" /db_xref="UniProtKB/Swiss-Prot:P16524" /translation="MEHLLNPKAREIEISGIRKFSNLVAQHEDVISLTIGQPDFFTPH HVKAAAKKAIDENVTSYTPNAGYLELRQAVQLYMKKKADFNYDAESEIIITTGASQAI DAAFRTILSPGDEVIMPGPIYPGYEPIINLCGAKPVIVDTTSHGFKLTARLIEDALTP NTKCVVLPYPSNPTGVTLSEEELKSIAALLKGRNVFVLSDEIYSELTYDRPHYSIATY LRDQTIVINGLSKSHSMTGWRIGFLFAPKDIAKHILKVHQYNVSCASSISQKAALEAV TNGFDDALIMREQYKKRLDYVYDRLVSMGLDVVKPSGAFYIFPSIKSFGMTSFDFSMA LLEDAGVALVPGSSFSTYGEGYVRLSFACSMDTLREGLDRLELFVLKKREAMQTINNG V*" gene complement(1471857..1473038) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" downshifts complement(1471891) /Source="Nicolas_upshifts" /id="D781" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="1.89632" /MaxDrop="6.70715" /score="-6.17975559" /energy="-4.7" /TU="NA" /idTUdmin="U1148" /TUdmin=0 /isTUend="TRUE" misc_feature complement(1473066..1473085) /Source="Nicolas_upshift_promotors" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1473082) /Source="Nicolas_upshifts" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" promotor_-10 complement(1473114..1473132) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1473126) /Source="Nicolas_upshifts" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" S_feature complement(1473128..1473196) /Source="Nicolas_S_feature" /locus_tag="new_1473128_1473196_c" /HighExp="M9-stat, Lbtran, Lbstat, T3.30H, T3.0H, T2.30H, M0t90, T4.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S508" promotor_-35 complement(1473147..1473152) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1473190..1473209) /Source="Nicolas_upshift_promotors" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1473196) /Source="Nicolas_upshifts" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" CDS complement(1473240..1473401) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097722.1" /db_xref="EnsemblGenomes-Gn:BSU14009" /db_xref="EnsemblGenomes-Tr:CAX52613" /db_xref="UniProtKB/Swiss-Prot:C0H406" /translation="MGTLVIFKENEMTVLEDISEETYLNMKKESADLQEEHPPYLIWH EDLHFDYGY*" gene complement(1473240..1473401) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" promotor_-10 complement(1473424..1473443) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1473437) /Source="Nicolas_upshifts" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" promotor_-35 complement(1473457..1473464) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1473538..1473545 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1473557 /Source="Nicolas_upshifts" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" promotor_-10 1473558..1473576 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1473605..1474516 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11553614, 12864845, 14731274, 14993307, 26844549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11553614, 12864845, 14731274, 14993307, 26844549; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling protein and response regulator for CheAactivity in response to attractants (chemotaxis)" /protein_id="NP_389284.1" /db_xref="EnsemblGenomes-Gn:BSU14010" /db_xref="EnsemblGenomes-Tr:CAB13274" /db_xref="GOA:P37599" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024181" /db_xref="InterPro:IPR036061" /db_xref="SubtiList:BG10823" /db_xref="UniProtKB/Swiss-Prot:P37599" /translation="MSLQQYEILLDSGTNELEIVKFGVGENAFGINVMKVREIIQPVE VTSVPHSHQHVEGMIKLRGEILPVISLFSFFGVEPEGSKDEKYIVTEFNKRKIVFHVG SVSQIHRVSWEAIEKPTSLNQGMERHLTGIIKLEDLMIFLPDYEKIIYDIESDSGVDT YNMHTEGFDERRTDKKLIIVEDSPLLMRLLQDELKEAGYNNIASFENGKEAYEYIMNL AENETDLSKQIDMIITDIEMPKMDGHRLTKLLKENPKSSDVPVMIFSSLITDDLRHRG EVVGADEQISKPEISDLIKKVDTYVIE*" gene 1473605..1474516 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" downshifts complement(1473610) /Source="Nicolas_upshifts" /id="D782" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="1.14523" /MaxDrop="3.62759" /score="-8.29055697" /energy="-7.7" /TU="NA" /idTUdmin="U1154" /TUdmin=968 /isTUend="FALSE" promotor_-35 1474059..1474067 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1474081..1474098 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1474084 /Source="Nicolas_upshifts" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1474501 /Source="Nicolas_upshifts" /id="D783" /incds=0 /nref=188 /ntot=251 /MaxReadThrough="4.61331" /MaxDrop="6.23797" /score="15.4598573" /energy="-13.1" /TU="U1152" /idTUdmin="U1153" /TUdmin="-1" /isTUend="TRUE" CDS complement(1474560..1475024) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of transcription factor ComK function via modulation of mRNA stability" /protein_id="NP_389285.1" /db_xref="EnsemblGenomes-Gn:BSU14020" /db_xref="EnsemblGenomes-Tr:CAB13275" /db_xref="InterPro:IPR025552" /db_xref="SubtiList:BG11202" /db_xref="UniProtKB/Swiss-Prot:P42430" /translation="MDDHAYTKDLQPTVENLSKAVYTVNRHAKTAPNPKYLYLLKKRA LQKLVKEGKGKKIGLHFSKNPRFSQQQSDVLISIGDYYFHMPPTKEDFEHLPHLGTLN QSYRNPKAQMSLTKAKHLLQEYVGMKEKPLVPNRQQPAYHKPVFKKLGESYF*" gene complement(1474560..1475024) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" downshifts complement(1474578) /Source="Nicolas_upshifts" /id="D784" /incds=0 /nref=212 /ntot=260 /MaxReadThrough="2.67186" /MaxDrop="6.66359" /score="16.1985615" /energy="-13.1" /TU="NA" /idTUdmin="U1154" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1475054..1475073) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1475064) /Source="Nicolas_upshifts" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" promotor_-35 complement(1475088..1475095) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1475150..1476442) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389286.2" /db_xref="EnsemblGenomes-Gn:BSU14030" /db_xref="EnsemblGenomes-Tr:CAB13276" /db_xref="GOA:O31695" /db_xref="InterPro:IPR004751" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13287" /db_xref="UniProtKB/Swiss-Prot:O31695" /translation="MDIFKNRNFVRLFFAALASQMGTTVGNMAFAFFLLDRFSSQPSY TTLAELMYSLPTIFVFLIVGVVADRFDRKKVAENCDWIRAGLTVVLFFTLFTGNIPLV FCILFIRSAVTKFFFPAENSLVQAILPKEHYAKAAGLNQMLFSIFMVFGVGIGAFMYN TIGIEGAIILDFVSFIISGLLIRSCRIPKEARQPNGAFSWRKTSVKDSINDFREGILY ILKNKLLASLIFGFFIFGFVNGGFAVLPMFTMKYGLAPDRYEWHTSVFTIALGFGLLA GSVIGTLISKKVKPHFLMSIPIFIAGLLIFVLGYTNILWVYYAAAFALGMCIGPINIA IGGWMPKIVHPKLMGRVSGMQDPFMMFAQSLTLGLVALLFPKFVSNIDYLYYGMGVII LLVFIFYFIALPKYSAQAVEVNVQEAFQEQPKKKARSV*" gene complement(1475150..1476442) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" downshifts complement(1475172) /Source="Nicolas_upshifts" /id="D785" /incds=0 /nref=37 /ntot=206 /MaxReadThrough="4.24449" /MaxDrop="4.31411" /score="3.5676583" /energy="-14.2" /TU="U1155" /idTUdmin="U1156" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1476466..1476485) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-10" upshifts complement(1476470) /Source="Nicolas_upshifts" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" promotor_-35 complement(1476501..1476505) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-35" CDS complement(1476518..1477012) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11011148, 16287140, 23832002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16287140, 23832002; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="murein L,D-transpeptidase" /protein_id="NP_389287.1" /db_xref="EnsemblGenomes-Gn:BSU14040" /db_xref="EnsemblGenomes-Tr:CAB13277" /db_xref="GOA:O34816" /db_xref="InterPro:IPR005490" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="PDB:1Y7M" /db_xref="PDB:2MTZ" /db_xref="PDB:3ZQD" /db_xref="PDB:4A1I" /db_xref="PDB:4A1J" /db_xref="PDB:4A1K" /db_xref="PDB:4A52" /db_xref="SubtiList:BG13288" /db_xref="UniProtKB/Swiss-Prot:O34816" /translation="MLTYQVKQGDTLNSIAADFRISTAALLQANPSLQAGLTAGQSIV IPGLPDPYTIPYHIAVSIGAKTLTLSLNNRVMKTYPIAVGKILTQTPTGEFYIINRQR NPGGPFGAYWLSLSKQHYGIHGTNNPASIGKAVSKGCIRMHNKDVIELASIVPNGTRV TINR*" gene complement(1476518..1477012) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" promotor_-10 complement(1477028..1477047) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1477044) /Source="Nicolas_upshifts" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" promotor_-35 complement(1477061..1477070) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1477069..1477929) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22767609, 24140208" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22767609, 24140208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported metallophosphoesterase (Mn2+ and Zn2+)" /protein_id="NP_389288.2" /db_xref="EnsemblGenomes-Gn:BSU14050" /db_xref="EnsemblGenomes-Tr:CAB13278" /db_xref="GOA:O34870" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR019546" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13289" /db_xref="UniProtKB/Swiss-Prot:O34870" /translation="MKKMSRRQFLKGMFGALAAGALTAGGGYGYARYLEPHMIETTEH TIKSSLIPHGFDGFKIVQFSDAHLSDYFTLEDLKTVILTINESKPDLIVFTGDIIDNP DTYQHHQAVIPLLRKLNAPFGKLCIYGNHDHGGYGTAVYKSLMTAGGFTVYRNGYQTL SLADGSKIEIASLDDLMLGNPDYEGTLSRLSDRLFSILLVHEPDAALKTTDYPVNLQL SGHTHGGQIQLPFYGPIITPPYGKVYTEGMYQTGSTHIYVNRGLGMTRLPLRFLAKPE ITVFTLKSTN*" gene complement(1477069..1477929) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" misc_feature complement(1477950..1477969) /Source="Nicolas_upshift_promotors" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1477963) /Source="Nicolas_upshifts" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" promotor_-35 1478000..1478007 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-35" promotor_-10 1478023..1478042 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-10" upshifts 1478036 /Source="Nicolas_upshifts" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" CDS 1478072..1478836 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" /EC_number="1.3.1.34" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2,4-dienoyl-CoA reductase" /protein_id="NP_389289.1" /db_xref="EnsemblGenomes-Gn:BSU14060" /db_xref="EnsemblGenomes-Tr:CAB13279" /db_xref="GOA:O34717" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13290" /db_xref="UniProtKB/Swiss-Prot:O34717" /translation="MEKKAVIITGGSSGMGKAMAKKQAELGWHVMVTGRNHEALEETK KEIQTFEGQVACFQMDVRSDSAASDMIKEAVKAFGRLDALINNAAGNFICPAEKLTPN GWKAVIEIVLNGTFFCSQAAARHWIDQKQQGVILNMAATYAWGAGAGVVHSAAAKAGV LSLTRTLAVEWGSKYGIRTNAIAPGPIERTGGAEKLFESEKAMARTMNSVPLGRLGTP EEIAALAAFLLSDEASYINGDCITMDGGQWLNPYPF*" gene 1478072..1478836 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" S_feature 1478837..1478985 /Source="Nicolas_S_feature" /locus_tag="new_1478837_1478985" /HighExp="T0.30H, T1.0H, B60, Sw, BC, LoTm, M9-stat, S8, S7, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S509" misc_feature 1478966..1478984 /Source="Nicolas_upshift_promotors" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1478987..1479136 /Source="Nicolas_S_feature" /locus_tag="new_1478987_1479136" /HighExp="T0.30H, M40t90, T1.0H, B60, BC, Sw, LPh, LoTm, M9-stat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0, 0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S510" upshifts 1478987 /Source="Nicolas_upshifts" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" downshifts complement(1479034) /Source="Nicolas_upshifts" /id="D786" /incds=0 /nref=3 /ntot=49 /MaxReadThrough="1.82681" /MaxDrop="3.39884" /score="-0.170855674" /energy="-4.8" /TU="NA" /idTUdmin="U1157" /TUdmin="-2542" /isTUend="FALSE" CDS 1479137..1480867 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall-binding protein" /protein_id="YP_003097723.1" /db_xref="EnsemblGenomes-Gn:BSU14071" /db_xref="EnsemblGenomes-Tr:CAX52614" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="UniProtKB/Swiss-Prot:O34320" /translation="MDEMVLLTQEWLNETYKGKSGYNSIEENGKTGWKTMYALTRALQ LELGITQTSDSFGPTTLRKLKELGPISTSTNSKKNIVKIIQGALYCKGYGPGGLTGTF GQGTKEAIAEMQLHMGLSKTDGVVTPKVFKALLNMDSYILLNGASEKVRSIQQWLNNK YYNRENFYFMPCDGLYSRDTQKSLVYAIQYEEGLSDSIANGNFGPTTQRLIPVLRIGE TDEKNSFIHLFQAALIFNGYNVPFDGVYSESVRSKVKAFQSFAKLQQSGTADFQTWAS LLVSTGDPNRKGVACDSITQITSDRAESLKRAGYKIVGRYLTNAPGSTLNKKIQPGEL ETILKSGLNVFPIYQTYGGATNYFNKEQGKKDAFAAYKAAKEYGFKNNTVIYFAVDYD AYGNDLNNNIIPHFEGINEIMNGFLGSTYKIGIYAPRNVCTIVSKKGLAFASFVSGMS TGFSGNLGYPLPYNWAFDQISTITVGNGSGMIEIDNDICSGLDNGVNTINIVPSENKK FFDQIDVLYETAEKYAQMQSDLNNGVKKTQLANELVAQYLRKDDYKGWKWVPTAGQID PIYREWAVKR*" gene 1479137..1480867 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" CDS 1480933..1481451 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097724.1" /db_xref="EnsemblGenomes-Gn:BSU14072" /db_xref="EnsemblGenomes-Tr:CAX52615" /db_xref="UniProtKB/Swiss-Prot:C0H408" /translation="MATYNAIIYSGGYSQTLRDFAGWTGDLLTTIQDMKLHAQEFNSP YDAAMKIIGNMYQFSLDDLFSDVDAINLANKTSVGANAQPLNIAIRDYYSNNDCMNRF TQFVNNRFDGSLDKIFSEAEYYLNTNLDPVVVPIRLAFKRAFDVEDYSEEIGKITAQA FRDVIEKKMISE*" gene 1480933..1481451 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" downshifts 1481449 /Source="Nicolas_upshifts" /id="D787" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.57306" /MaxDrop="3.8585" /score="8.20824413" /energy="-13" /TU="U1158,U1159" /idTUdmin="U1158" /TUdmin="-682" /isTUend="FALSE" promotor_-35 1481494..1481499 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1481512..1481531 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1481515 /Source="Nicolas_upshifts" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" CDS 1481547..1482095 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389291.1" /db_xref="EnsemblGenomes-Gn:BSU14080" /db_xref="EnsemblGenomes-Tr:CAB13281" /db_xref="GOA:O31696" /db_xref="SubtiList:BG13292" /db_xref="UniProtKB/Swiss-Prot:O31696" /translation="MKKLLKKLVVLFLSSLVIIFNVWYFIICAFSPEYYQNTNLTSNE IIRFEKLYHIDFPDETKFIKAREYLAGPGGDTSAVLYVSLPTKRVEKVLSDYTYMKIN YTDNVGSMYGVDVSKSVAGLTTLTFGTYDKKGTFYNMKHDDDWMYKGTDWNLYFWTAA SYNAVIFVFVLVIVKQMNKILN*" gene 1481547..1482095 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" S_feature 1482096..1482247 /Source="Nicolas_S_feature" /locus_tag="new_1482096_1482247" /HighExp="HiOs, LPhT, Salt, T0.0H, HiTm, T-0.40H, Fru, T-1.10H, LPh, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S511" CDS 1482248..1483471 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19244251, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative cyclic-di-GMP receptor (no phosphodiesterase activity)" /protein_id="NP_389292.1" /db_xref="EnsemblGenomes-Gn:BSU14090" /db_xref="EnsemblGenomes-Tr:CAB13282" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR018842" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035919" /db_xref="PDB:2BAS" /db_xref="PDB:2W27" /db_xref="SubtiList:BG13293" /db_xref="UniProtKB/Swiss-Prot:O35014" /translation="MLDPLDILTNIDDVLPYYQAIFSAEEQKVVGYEVLGRILADSEI QSLGPFFLDAGIPEEYKLEVDNRIIRQALDRFLEADSDLLIFMNQDANLLMLDHGESF LELLKEYEAKGIELHRFVLEITEHNFEGDIEQLYHMLAYYRTYGIKIAVDNIGKESSN LDRIALLSPDLLKIDLQALKVSQPSPSYEHVLYSISLLARKIGAALLYEDIEANFQLQ YAWRNGGRYFQGYYLVSPSETFLERDVLKQRLKTEFHQFITHEKKKLETVYEHSEQFY KRVHQAVTSLRKNNLSSDDDFIKKLAEELTDCSFRIYMCDEEGDQLTGNVFKQDGEWI YQPEYAEKNWSWRPYFLENIMRMRNLRKGFFSDLYSDLETGEMIRTFSYPMDDQMYLF IDLPYSYLYEQDGLI*" gene 1482248..1483471 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" promotor_-10 complement(1483434..1483452) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1483444) /Source="Nicolas_upshifts" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1483450 /Source="Nicolas_upshifts" /id="D788" /incds=0 /nref=132 /ntot=229 /MaxReadThrough="3.48305" /MaxDrop="4.61382" /score="32.6727777" /energy="-7.5" /TU="U1159" /idTUdmin="U1160" /TUdmin="-1" /isTUend="TRUE" promotor_-35 complement(1483467..1483472) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1483520..1483527 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1483539..1483640 /Source="Nicolas_S_feature" /locus_tag="new_1483539_1483640" /HighExp="B36, B60, nit, Pyr, BI, HiOs, T-0.40H, S5, GM 15, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S512" upshifts 1483539 /Source="Nicolas_upshifts" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" promotor_-10 1483542..1483561 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" misc_RNA 1483557..1483640 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" /product="regulatory RNA controlling iron-dependent metabolism" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629, 24576839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629, 24576839; Product type n: RNA" /function="12: Regulatory functions" gene 1483557..1483640 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" downshifts 1483597 /Source="Nicolas_upshifts" /id="D789" /incds=0 /nref=61 /ntot=192 /MaxReadThrough="6.41968" /MaxDrop="7.54463" /score="16.5898261" /energy="-8.8" /TU="U1159,U1162" /idTUdmin="U1159" /TUdmin="-74" /isTUend="FALSE" promotor_-35 1483651..1483656 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1483671..1483955 /Source="Nicolas_S_feature" /locus_tag="new_1483671_1483955" /HighExp="S4, H2O2, S5, Paraq, B60, nit, GM 10, B36, GM 25, GM 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147452" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S513" upshifts 1483671 /Source="Nicolas_upshifts" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" promotor_-10 1483673..1483691 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-10" promotor_-35 1483932..1483938 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" promotor_-10 1483952..1483963 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" S_feature 1483957..1484044 /Source="Nicolas_S_feature" /locus_tag="new_1483957_1484044" /HighExp="S5, S4, H2O2, B60, Paraq, nit, B36, GM 10, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigEF, SigA" /TUshortPSig="0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S514" upshifts 1483957 /Source="Nicolas_upshifts" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" misc_feature 1484033..1484052 /Source="Nicolas_upshift_promotors" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1484046 /Source="Nicolas_upshifts" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" CDS 1484117..1484356 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16387657, 18436958; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-specific modification enzyme subunit" /protein_id="NP_389293.1" /db_xref="EnsemblGenomes-Gn:BSU14100" /db_xref="EnsemblGenomes-Tr:CAB13283" /db_xref="InterPro:IPR014904" /db_xref="PDB:2FFG" /db_xref="SubtiList:BG13294" /db_xref="UniProtKB/Swiss-Prot:O34588" /translation="MSQLMGIITRLQSLQETAEAANEPMQRYFEVNGEKICSVKYFEK NQTFELTVFQKGEKPNTYPFDNIDMVSIEIFELLQ*" gene 1484117..1484356 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" S_feature 1484357..1484465 /Source="Nicolas_S_feature" /locus_tag="new_1484357_1484465" /HighExp="H2O2, LoTm, G135, Paraq, G180, LBGexp, G150, Oxctl, dia0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S515" CDS 1484466..1484984 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16165328, 24464998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding enzyme component" /protein_id="NP_389294.1" /db_xref="EnsemblGenomes-Gn:BSU14110" /db_xref="EnsemblGenomes-Tr:CAB13284" /db_xref="InterPro:IPR007405" /db_xref="SubtiList:BG13295" /db_xref="UniProtKB/Swiss-Prot:O34776" /translation="MADSFLFYNLSEAQMTFQDVMERLKAFVQKDPRSSYVLSIGTDS QVYRDYTKFITALHLHRTGKGAWGCLKNHTVDRPIHSLREKISLETAYSQETAAHILD GHLMDITDLLLPFTGEGADLTFEVHLDIGKKGLTKDLIQEMTGRITSMGIEAKIKPDS YTAFSYANRFTK*" gene 1484466..1484984 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" promotor_-35 1485021..1485028 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1485042..1485061 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1485056 /Source="Nicolas_upshifts" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" CDS 1485118..1485315 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18840696, 24534728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18840696, 24534728; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of AbrB repressor" /protein_id="NP_389295.1" /db_xref="EnsemblGenomes-Gn:BSU14120" /db_xref="EnsemblGenomes-Tr:CAB13285" /db_xref="GOA:O31697" /db_xref="InterPro:IPR025446" /db_xref="PDB:2LZF" /db_xref="SubtiList:BG13334" /db_xref="UniProtKB/Swiss-Prot:O31697" /translation="MRMSLIGERFTEEEQKLLLNILINHEYAIELLSSEINDIETGTK NVDGTTYKKLVTLYDRFRFEN*" gene 1485118..1485315 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" downshifts 1485311 /Source="Nicolas_upshifts" /id="D790" /incds=0 /nref=114 /ntot=265 /MaxReadThrough="5.72556" /MaxDrop="4.65809" /score="2.45376472" /energy="-6.8" /TU="U1165,U1166" /idTUdmin="U1162" /TUdmin=12 /isTUend="TRUE" S_feature 1485356..1485452 /Source="Nicolas_S_feature" /locus_tag="new_1485356_1485452" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, M0t90, T1.0H, T5.0H, T2.30H, T1.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.23094000000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S516" CDS 1485453..1485896 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11985717; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA-binding protein" /protein_id="NP_389296.1" /db_xref="EnsemblGenomes-Gn:BSU14130" /db_xref="EnsemblGenomes-Tr:CAB13286" /db_xref="PDB:1YAV" /db_xref="SubtiList:BG13296" /db_xref="UniProtKB/Swiss-Prot:O31698" /translation="MISLQSDQLLEATVGQFMIEADKVAHVQVGNNLEHALLVLTKTG YTAIPVLDPSYRLHGLIGTNMIMNSIFGLERIEFEKLDQITVEEVMLTDIPRLHINDP IMKGFGMVINNGFVCVENDEQVFEGIFTRRVVLKELNKHIRSLNK*" gene 1485453..1485896 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" S_feature 1485897..1486004 /Source="Nicolas_S_feature" /locus_tag="new_1485897_1486004" /HighExp="M0t90, M40t90, M9-stat, T1.0H, T3.30H, T3.0H, T4.0H, S2, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S517" promotor_-35 1485972..1485977 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1485992..1486011 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1486006 /Source="Nicolas_upshifts" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" CDS 1486045..1486926 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14636591, 16352834, 16395550, 23139400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14636591, 16352834, 16395550, 23139400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of citB and citZ" /protein_id="NP_389297.1" /db_xref="EnsemblGenomes-Gn:BSU14140" /db_xref="EnsemblGenomes-Tr:CAB13287" /db_xref="GOA:O34827" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13297" /db_xref="UniProtKB/Swiss-Prot:O34827" /translation="MQLQELHMLVVLAEELNMRKAAERLFVSQPALSQRLQTIEKAWG TKIFLRSQKGLTVTPAGEKIIQFANDVTLEQERIRENIDELEGEIHGTLKLAVASIIG QHWLPKVLKTYVEKYPNAKISLITGWSSEMLKSLYEDQVHIGIIRGNPEWKGRKDYLM TDHLYLVDTEISCIEDIAHTERPFIQFKSDSTYFQEIQHWWHQKFKTSPKQTILVDQI ETCKQMALHGIGYAILPSVTLQNEDKVNKMPLLDMKGHPIGRDTWLLGYEPAFELKQV QAFVQVIKDMLDQENPF*" gene 1486045..1486926 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" downshifts 1486905 /Source="Nicolas_upshifts" /id="D791" /incds=0 /nref=168 /ntot=242 /MaxReadThrough="1.76921" /MaxDrop="5.2505" /score="37.6563581" /energy="-8.3" /TU="NA" /idTUdmin="U1165" /TUdmin=0 /isTUend="TRUE" promotor_-35 1486961..1486968 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1486983..1487002 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1486988 /Source="Nicolas_upshifts" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" CDS 1487038..1487514 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin (acts in lipid desaturation)" /protein_id="NP_389298.1" /db_xref="EnsemblGenomes-Gn:BSU14150" /db_xref="EnsemblGenomes-Tr:CAB13288" /db_xref="GOA:O34737" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13298" /db_xref="UniProtKB/Swiss-Prot:O34737" /translation="MAKALITYASMSGNTEDIAFIIKDTLQEYELDIDCVEINDMDAS CLTSYDYVLIGTYTWGDGDLPYEAEDFFEEVKQIQLNGLKTACFGSGDYSYPKFCEAV NLFNVMLQEAGAAVYQETLKIELAPETDEDVESCRAFARGFLAWADYMNKEKIHVS*" gene 1487038..1487514 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" CDS 1487504..1488397 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12354229, 24214949" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389299.1" /db_xref="EnsemblGenomes-Gn:BSU14160" /db_xref="EnsemblGenomes-Tr:CAB13289" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG13299" /db_xref="UniProtKB/Swiss-Prot:O34879" /translation="MFHKGATAVTASAFSGYFVAVQREGIFHYSLEQGWRKLFRLKSK IHCISYIGPYLFGVGEKGTVIRSADEGKTWTMSSFPTNATVWAITGRNNGFVCAHGKH CIYVSDDFGVSWRVAKPFAEFHNPPVIRSLCLHGGNLFIGTQIHEYFGGIWAYDIKRD TVQVVKKEKNRMTASMLVFNENWLVAAMGSVKGKHGAVTVRNLLNGEEFTIQSSMIRN EESFLDLSEDDGIIYVTTTQDENGFSRIYQVDLEARSLKWFDTIKGHGWRVANQKENF FCAGLYECKFVQPYEVSAMIH*" gene 1487504..1488397 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" CDS 1488413..1488868 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin" /protein_id="NP_389300.2" /db_xref="EnsemblGenomes-Gn:BSU14170" /db_xref="EnsemblGenomes-Tr:CAB13290" /db_xref="GOA:O34589" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001226" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13300" /db_xref="UniProtKB/Swiss-Prot:O34589" /translation="MAKILLVYATMSGNTEAMADLIEKGLQEALAEVDRFEAMDIDDA QLFTDYDHVIMGTYTWGDGDLPDEFLDLVEDMEEIDFSGKTCAVFGSGDTAYEFFCGA VDTLEAKIKERGGDIVLPSVKIENNPEGEEEEELINFGRQFAKKSGCAV*" gene 1488413..1488868 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" promotor_-10 complement(1488684..1488703) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1488697) /Source="Nicolas_upshifts" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1488717..1488725) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1488862 /Source="Nicolas_upshifts" /id="D792" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="6.48855" /MaxDrop="3.75748" /score="20.7202933" /energy="-9" /TU="U1168" /idTUdmin="U1165" /TUdmin=1957 /isTUend="FALSE" promotor_-35 1488907..1488914 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1488928..1488947 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1488929 /Source="Nicolas_upshifts" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" CDS 1488973..1489683 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" /EC_number="2.3.1.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5411754, 10368155, 11910040, 12682299, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5411754, 10368155, 11910040, 12682299, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetrahydrodipicolinate N-acetyltransferase" /protein_id="NP_389301.2" /db_xref="EnsemblGenomes-Gn:BSU14180" /db_xref="EnsemblGenomes-Tr:CAB13291" /db_xref="GOA:O34981" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR013710" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR019873" /db_xref="SubtiList:BG13301" /db_xref="UniProtKB/Swiss-Prot:O34981" /translation="MKMMDANEIISFIQNSTKSTPVKVYVKGELEGINFGESAKAFIN GNTGVVFGEWSEIQTAIEENQSKIEDYVVENDRRNSAIPMLDLKNIKARIEPGAIIRD QVEIGDNAVIMMGASINIGSVIGEGTMIDMNVVLGGRATVGKNCHIGAGSVLAGVIEP PSAKPVVIEDDVVIGANAVVLEGVTVGKGAVVAAGAIVVNDVEPYTVVAGTPAKKIKD IDEKTKGKTEIKQELRQL*" gene 1488973..1489683 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" downshifts complement(1488982) /Source="Nicolas_upshifts" /id="D793" /incds=0 /nref=60 /ntot=165 /MaxReadThrough="1.03272" /MaxDrop="4.75802" /score="28.9046709" /energy="-15" /TU="NA" /idTUdmin="U1171" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1489092..1489096) /Source="Nicolas_upshift_promotors" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1489092) /Source="Nicolas_upshifts" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1489114) /Source="Nicolas_upshift_promotors" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1489753..1490877 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" /EC_number="3.5.1.47" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14627808, 17093042, 24261876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14627808, 17093042, 24261876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-diaminopimelate deacetylase" /protein_id="NP_389302.1" /db_xref="EnsemblGenomes-Gn:BSU14190" /db_xref="EnsemblGenomes-Tr:CAB13292" /db_xref="GOA:O34916" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR023905" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13302" /db_xref="UniProtKB/Swiss-Prot:O34916" /translation="MKIEELIAIRRDLHRIPELGFQEFKTQQYLLNVLEQYPQDRIEI EKWRTGLFVKVNGTAPEKMLAYRADIDALSIEEQTGLPFASEHHGNMHACGHDLHMTI ALGIIDHFVHHPVKHDLLFLFQPAEEGPGGAEPMLESDVLKKWQPDFITALHIAPELP VGTIATKSGLLFANTSELVIDLEGKGGHAAYPHLAEDMVVAASTLVTQLQTIISRNTD PLDSAVITVGTITGGSAQNIIAETAHLEGTIRTLSEESMKQVKERIEDVVKGIEIGFR CKGKVTYPSVYHQVYNTSGLTEEFMSFVAEHQLATVIEAKEAMTGEDFGYMLKKYPGF MFWLGADSEHGLHHAKLNPDENAIETAVHVMTGYFSVYAN*" gene 1489753..1490877 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" promotor_-35 1490889..1490895 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1490909..1490920 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1490911 /Source="Nicolas_upshifts" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" promotor_-10 complement(1490915..1490929) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1490939..1490943) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1490939..1491184 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389303.1" /db_xref="EnsemblGenomes-Gn:BSU14200" /db_xref="EnsemblGenomes-Tr:CAB13293" /db_xref="InterPro:IPR005370" /db_xref="SubtiList:BG13303" /db_xref="UniProtKB/Swiss-Prot:O34783" /translation="MAKKIGIEQSLSDVEAALKEKGYDVVMMKSPADAQGCDCCVVTG LDNNVQGIADTVTQAPVITASGMTAEEICSEVESRIQ*" gene 1490939..1491184 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" upshifts complement(1490940) /Source="Nicolas_upshifts" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1491172 /Source="Nicolas_upshifts" /id="D794" /incds=0 /nref=238 /ntot=269 /MaxReadThrough="3.49553" /MaxDrop="5.88829" /score="3.56597112" /energy="-9.9" /TU="U1172" /idTUdmin="U1168" /TUdmin=0 /isTUend="TRUE" S_feature 1491217..1492167 /Source="Nicolas_S_feature" /locus_tag="new_1491217_1492167" /HighExp="S4, S5, S6, S3, S7, S8, LoTm, BT, B36, G135" /AntisenseName="ykuT" /AntisenseCor="-0.479447808227356" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S518" CDS complement(1491221..1492024) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" /function="16.6: Maintain" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12626684, 17665170, 18310427, 19252899, 21150093" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12626684, 17665170, 18310427, 19252899, 21150093; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small-conductance mechanosensitive channel" /protein_id="NP_389304.2" /db_xref="EnsemblGenomes-Gn:BSU14210" /db_xref="EnsemblGenomes-Tr:CAB13294" /db_xref="GOA:O34897" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13304" /db_xref="UniProtKB/Swiss-Prot:O34897" /translation="MDFIKQYDWAGLITNAGVLLIKLAIMILLYFIVRSLGMKIIKHL FAKFEEQNSLSIGRAHTLRSLTLNIFAYTLIFIFFVMVLDLFHYDPSALLAGAGIVGL AVGFGAQGLVSDIVTGFFILLEKQLDVGDYITVSTFDGIVEQVGLRTTQIRSFDGTLH YIPNRNITNVSNHSRGTMQALVDIKVPAERNIDEMIHILQQVCDETAAALPQIKEGPN VIGIQELGTSEIVIRVIAKTENMEQWRVERVLRKEIKNAFDRAFPKETE*" gene complement(1491221..1492024) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" downshifts complement(1491233) /Source="Nicolas_upshifts" /id="D795" /incds=0 /nref=16 /ntot=131 /MaxReadThrough="1.65551" /MaxDrop="4.4361" /score="29.0050313" /energy="-9.9" /TU="NA" /idTUdmin="U1174" /TUdmin="-7" /isTUend="TRUE" promotor_-10 complement(1492075..1492094) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1492084) /Source="Nicolas_upshifts" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" promotor_-35 complement(1492108..1492115) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1492140..1492147 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-35" promotor_-10 1492162..1492181 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-10" S_feature 1492169..1492260 /Source="Nicolas_S_feature" /locus_tag="new_1492169_1492260" /HighExp="LPhT, Salt, Etha, M9-stat, M0t90, T4.0H, T5.0H, S4, Heat, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S519" upshifts 1492169 /Source="Nicolas_upshifts" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" CDS 1492261..1492803 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" /EC_number="1.11.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:22938038, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22938038, 27683249; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biofilm-specific peroxidase; 2-cys peroxiredoxin" /protein_id="NP_389305.1" /db_xref="EnsemblGenomes-Gn:BSU14220" /db_xref="EnsemblGenomes-Tr:CAB13295" /db_xref="GOA:O34564" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13305" /db_xref="UniProtKB/Swiss-Prot:O34564" /translation="MAERMVGKQAPRFEMEAVLASKEFGKVSLEENMKNDKWTVLFFY PMDFTFVCPTEITAMSDRYDEFEDLDAEVIGVSTDTIHTHLAWINTDRKENGLGQLKY PLAADTNHEVSREYGVLIEEEGVALRGLFIINPEGELQYQTVFHNNIGRDVDETLRVL QALQTGGLCPANWKPGQKTL*" gene 1492261..1492803 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" CDS 1492875..1493321 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" /EC_number="1.8.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15937154, 16132829, 16418167" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 16132829, 16418167; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_389306.2" /db_xref="EnsemblGenomes-Gn:BSU14230" /db_xref="EnsemblGenomes-Tr:CAB13296" /db_xref="GOA:O31699" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:2B5X" /db_xref="PDB:2B5Y" /db_xref="SubtiList:BG13306" /db_xref="UniProtKB/Swiss-Prot:O31699" /translation="MKLRQPMPELTGEKAWLNGEVTREQLIGEKPTLIHFWSISCHLC KEAMPQVNEFRDKYQDQLNVVAVHMPRSEDDLDPGKIKETAAEHDITQPIFVDSDHAL TDAFENEYVPAYYVFDKTGQLRHFQAGGSGMKMLEKRVNRVLAETE*" gene 1492875..1493321 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" downshifts 1493329 /Source="Nicolas_upshifts" /id="D796" /incds=0 /nref=58 /ntot=211 /MaxReadThrough="3.11112" /MaxDrop="4.73023" /score="10.8864177" /energy="-5.4" /TU="U1175" /idTUdmin="U1172" /TUdmin=0 /isTUend="TRUE" promotor_-35 1493714..1493721 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1493734 /Source="Nicolas_upshifts" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" promotor_-10 1493736..1493755 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1493787..1494362 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 27902860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 27902860; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of comK" /protein_id="NP_389307.1" /db_xref="EnsemblGenomes-Gn:BSU14240" /db_xref="EnsemblGenomes-Tr:CAB13297" /db_xref="GOA:O34857" /db_xref="SubtiList:BG13307" /db_xref="UniProtKB/Swiss-Prot:O34857" /translation="MFNEREALRLRLEQLNEAEVKVIREYQIERDKIYAKLRELDRNG SPSEIKKDFRSEKKPDSLPVLAELAAQEIRSYQPQSQQQSVQPQLQSISSLPAGIPDG TTRRRRGTARPGSKAAKLREAAIKTLKRHNAAIKSSELQKEIEKESGLEIPNMTTFMQ SLIKMYPEVKKPYRGQYILEGEIESAESANE*" gene 1493787..1494362 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" downshifts 1494340 /Source="Nicolas_upshifts" /id="D797" /incds=0 /nref=246 /ntot=258 /MaxReadThrough="1.77207" /MaxDrop="6.35121" /score="17.7584572" /energy="-9" /TU="NA" /idTUdmin="U1176" /TUdmin=0 /isTUend="TRUE" CDS complement(1494403..1495368) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" /experiment="publication(s) with functional evidences, PMID:8990290, 15383836, 15743949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 15383836, 15743949; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein cse15" /protein_id="NP_389308.1" /db_xref="EnsemblGenomes-Gn:BSU14250" /db_xref="EnsemblGenomes-Tr:CAB13298" /db_xref="GOA:O31700" /db_xref="SubtiList:BG12251" /db_xref="UniProtKB/Swiss-Prot:O31700" /translation="MKRSGPFFHDVSQENLYLKSELSRCHKLISELEASYFHQKNNKL LKENTDMKEKLQQLSAELTHMSTKEKHASHTSQTLHQIRAELLDKIVVLQELLSAETY KRRAEIEEKHKLHIAKVKIEEENKNLHKRISELQASIEQEQNALLQAKQQAELIKAEN GRLKEQMVEKEYQLKHIKIEVDHMKDRIIETKERLLDIEKTKEKLFHETIISYKRQLD ESDAWIASHFADIDGGTKQKEKTEEEAPAAYAQPNHVETILEDVTKQIHVLQKQLAHA QSSDQAKSHTIEELKNRAAEEKPYQKWVYKLNLEKENKPSQKKPQ*" gene complement(1494403..1495368) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" downshifts complement(1494416) /Source="Nicolas_upshifts" /id="D798" /incds=0 /nref=47 /ntot=67 /MaxReadThrough="2.24884" /MaxDrop="5.5936" /score="3.60334458" /energy="-7.2" /TU="NA" /idTUdmin="U1178" /TUdmin=0 /isTUend="TRUE" promotor_-35 1494712..1494713 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1494731..1494750 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1494737..1495461 /Source="Nicolas_S_feature" /locus_tag="new_1494737_1495461" /HighExp="dia15, Diami, dia5, H2O2, G135, G150, G180, LBGexp, Paraq, Lbexp" /AntisenseName="yknT" /AntisenseCor="-0.36512493899072102" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S520" upshifts 1494737 /Source="Nicolas_upshifts" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" promotor_-10 complement(1495389..1495407) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1495410) /Source="Nicolas_upshifts" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" promotor_-35 complement(1495422..1495427) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1495448..1495454 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1495464 /Source="Nicolas_upshifts" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" promotor_-10 1495468..1495487 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1495505..1496104 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" /EC_number="2.7.7.77" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10978347; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein A" /protein_id="NP_389309.1" /db_xref="EnsemblGenomes-Gn:BSU14260" /db_xref="EnsemblGenomes-Tr:CAB13299" /db_xref="GOA:O31701" /db_xref="InterPro:IPR013482" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12621" /db_xref="UniProtKB/Swiss-Prot:O31701" /translation="MKHVNVLLAGGASRRFGEPKAFVKWKGRMLYECAKEALGEQTVI ISRPEFIDRFQENGENEVYQDAEPFQGMGPLAGIYTAFKKTDGDLYTVLSCDTPLIQR RTMLELKRLMIAGADAVVPISDGQVQPLIAIYHKRIMPVLYDQLSEKRLRISDLLGRI SVCYVQAENIGANPAEFININTRDDFSCLEEKSNSLKRD*" gene 1495505..1496104 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" CDS 1496155..1497174 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" /EC_number="2.7.7.80" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17223713; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin biosynthesis adenylyltransferase" /protein_id="NP_389310.1" /db_xref="EnsemblGenomes-Gn:BSU14270" /db_xref="EnsemblGenomes-Tr:CAB13300" /db_xref="GOA:O31702" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG12624" /db_xref="UniProtKB/Swiss-Prot:O31702" /translation="MEERYSRQIRFKQIGEEGQKRLADSHVLIVGAGALGTAGAEGLS RAGVGTITIIDRDYVEWSNLQRQQLYTESDAKLRMPKAMAAKEHLSAINSEIHIEAYV TEGTAETLEPLIEKADVVIDATDNFETRMLINDLAQKTKTPWVYGACVSSQGMFMTVI PGETPCLSCLFEQIPVGGATCDTAGIIPPAVHIVSAYQQAEALKLLTGQKEAIQRGFV TFDVWNNSHMKINVNHVRREECPSCGANAVYPYLQDWNTPKAAVLCGRDTVQVRSESL KRIPKQELIKRLKTIGKVEANAFLLHIFYEDFRIVIFNDGRALVHGTNDVKEANSVLA RVIGL*" gene 1496155..1497174 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" CDS 1497192..1498484 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" /EC_number="2.10.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11428898, 12006571, 18959753, 21206014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdate to molybdopterin ligation enzyme" /protein_id="NP_389311.1" /db_xref="EnsemblGenomes-Gn:BSU14280" /db_xref="EnsemblGenomes-Tr:CAB13301" /db_xref="GOA:O31703" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR005110" /db_xref="InterPro:IPR005111" /db_xref="InterPro:IPR036135" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036688" /db_xref="SubtiList:BG12623" /db_xref="UniProtKB/Swiss-Prot:O31703" /translation="MLEKRTPIPVDEAVRRVCHFQKQGETEWVALEDSLHRFLAEDIT ADHHVPAFDRSPYDGFAVRACDTAEASRENPVRFEVIDHIGAGAVSEKELGPFQAVRI MTGAQIPEGADAVVMIELTQAFEENGKSFMSLKRRFQTGDNISKTGEDAQKGSVLLTK GTRVTPGVTALLATFGYASVPVVRKPVVGIIATGTELLNVSDPLEPGKIRNSNASMVY AQAIEAGATPLYLGKISDELDKSFAAVKEAMKKVDFLITTGGVSVGDFDFLPAIYEKL GADVLFNKVAMRPGSVTTVAHANDMLLFGLSGNPSACYVGFELFVKPIIQTWLLNETP HSICAEAVLTKDFPKPNPFTRFVRALVHHQEGKLLATPVGLDKSSSVTSLADANAFII LPGGTRGYESGRTVQVLLIREENGSEWPWSVLSRSSKL*" gene 1497192..1498484 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" CDS 1498445..1498966 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9219527, 12682065, 12719427; Product type c: carrier" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein B" /protein_id="NP_389312.1" /db_xref="EnsemblGenomes-Gn:BSU14290" /db_xref="EnsemblGenomes-Tr:CAB13302" /db_xref="GOA:O31704" /db_xref="InterPro:IPR004435" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12622" /db_xref="UniProtKB/Swiss-Prot:O31704" /translation="MALVRPFPIVQVVGFQNSGKTTFIERILEKASEQGVHLGCLKHH GHGGEPQTLTEGKDTDRYKAAGADVTAVEGAGVLQLTARRNWDLARLIELYQFLETDC LLIEGFKKAPYPKVVILSEKEDLEALQAVNIIAIIYRKKEHMTEHQGLPVFHADDPVA VDFVLSQLKGESA*" gene 1498445..1498966 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" CDS 1498966..1499439 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" /EC_number="2.8.1.12" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 18092812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (large subunit)" /protein_id="NP_389313.1" /db_xref="EnsemblGenomes-Gn:BSU14300" /db_xref="EnsemblGenomes-Tr:CAB13303" /db_xref="GOA:O31705" /db_xref="InterPro:IPR003448" /db_xref="InterPro:IPR036563" /db_xref="SubtiList:BG12620" /db_xref="UniProtKB/Swiss-Prot:O31705" /translation="MERFEITKTPINTENIIKKVEKREAGAITTFIGTVREWTNGKRT VRLEYEAYEPMAVQMLAQIGAEIEEKWEGASAAITHRIGVLDIGEAAVVIAVSSPHRK AAYEANEYAIERIKQIVPIWKKEIWEDGEQWIGDQLETTAYPNGKPDLSEGEQHD*" gene 1498966..1499439 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" CDS 1499432..1499665 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 17223713, 19946146; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (small subunit)" /protein_id="NP_389314.1" /db_xref="EnsemblGenomes-Gn:BSU14310" /db_xref="EnsemblGenomes-Tr:CAB13304" /db_xref="GOA:O31706" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010034" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="SubtiList:BG12619" /db_xref="UniProtKB/Swiss-Prot:O31706" /translation="MIKILLFAGLAEQAGTQAIEIDMEQATTDEIKASLKEQYGLESI DTAMIAVNESYVKENTSVSSGDTVAIIPPVSGG*" gene 1499432..1499665 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" downshifts 1499644 /Source="Nicolas_upshifts" /id="D799" /incds=0 /nref=87 /ntot=240 /MaxReadThrough="1.14308" /MaxDrop="5.73073" /score="32.0123217" /energy="-16.9" /TU="NA" /idTUdmin="U1177" /TUdmin=2 /isTUend="TRUE" promotor_-35 1499710..1499715 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-35" promotor_-10 1499732..1499750 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-10" upshifts 1499740 /Source="Nicolas_upshifts" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" S_feature 1499752..1499838 /Source="Nicolas_S_feature" /locus_tag="new_1499752_1499838" /HighExp="S4, S5, S3, T5.0H, T4.0H, Pyr, S6, T3.30H, M9-stat, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S521" promotor_-35 1499828..1499831 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1499840 /Source="Nicolas_upshifts" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 1499846..1499865 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1499889..1501646 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389315.1" /db_xref="EnsemblGenomes-Gn:BSU14320" /db_xref="EnsemblGenomes-Tr:CAB13305" /db_xref="GOA:O31707" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13241" /db_xref="UniProtKB/Swiss-Prot:O31707" /translation="METFKRLKMYYWPYRKVFMWSLLAMLLMTAITVVYPIILQITID EIVLGRQYQLAAWVSLGFIAVMVLKGMATFFHQYLGDMFGIKSVYRLRNGLYEKLQRL SFSYYDNAKTGDLMSRLTADVEGLRFFLSYGLAELIRFGLLVAISLSVMFYYSVPLTL VTIAVLPFLAVAVYRFDKRVHPAFRGIRKSFAKLNTKVQENISGINTVKSLSREDFQI STFNKANAEYRAQYLQTSSIWSAYFPLMEFIGNTCIVALLSYGGYLVMQNQLNPGELV AFFSLVNYMMWPIMNLGFVINMFSQAKASGERLLDILEKEEDITDHPHALHKQKLTGD VHFKNVSLAYGKEQTNALCNVSFEANSGKVIGLLGPTGSGKSSVTQLLTRFYSPVGGM ITIDHKPITDYSLKTLRSNIGVVLQESFLFSSTIRSNISYGRPDASMEDVIEAAKRAQ AHNFIMELPDGYDTMLGERGMGLSGGQKQRIAIARAICLNPSILILDDATSAVDMQTE HSIQLALKEVMKNRTTFIVAHRISSLKHADEILVFNKGRIRERGTHHELLEKGGYYKK IYDLQYRDVKMINEPHEVG*" gene 1499889..1501646 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" CDS 1501658..1503472 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389316.1" /db_xref="EnsemblGenomes-Gn:BSU14330" /db_xref="EnsemblGenomes-Tr:CAB13306" /db_xref="GOA:O31708" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13242" /db_xref="UniProtKB/Swiss-Prot:O31708" /translation="MKQAKKQGVLERFYYSSDEIIEKPFNWAQMWRLLSYVKPYRKTI LPLSFLTVLIGTAVKLVIPILIGVYVLDQAITGRNSELLIQLIFIISGLYVLNYAANV LRIRWMNQLGQHVIYDLRQHLFTHVQRLSHRFFDQRSAGSILVRIMNDINSLQELFTS GVINLLTDLLLLAGVIIILFTLSPELTIAIMVTLPIMFFISTSLRKKIRRSWQTVRLK QSKLNSHLNESIQGIRVTQAFTQEEENMAYFDGVNQENYESWREATRKNAMFRPLVEM TNAIGTAVLIWYGATLIMNETITIGVFVSFAFYLGMFWEPISRLGQVYNQLLMGMASS ERIFEFLDEQPNVKEKPNAIHNEKINGEISFEEVEFSYDEKRKALHAVSFSIPAGSTL ALVGHTGSGKTTIANLISRFYDAAGGTIKIDGIPIKDLSLASLRSQISIVLQDTFIFS GTIMENIRFGRPNASDEEVMKASQAVGADEFISDLAEGYATEVEERGSVLSAGQRQLI SFARALLADPAIIILDEATASIDTETEVKIQQALKTLLKGRTAVMIAHRLSTIRDADR IIVLDHGRKIEEGNHDQLLAKGGIYAGLVKAQYSTAIE*" gene 1501658..1503472 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" promotor_-10 complement(1502095..1502114) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1502105) /Source="Nicolas_upshifts" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1502129..1502136) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1503523..1503532 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1503544..1503559 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1503548 /Source="Nicolas_upshifts" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" CDS 1503582..1504277 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of permease exporting the starvation-induced killing protein" /protein_id="NP_389317.1" /db_xref="EnsemblGenomes-Gn:BSU14340" /db_xref="EnsemblGenomes-Tr:CAB13307" /db_xref="GOA:O31709" /db_xref="InterPro:IPR006977" /db_xref="SubtiList:BG13243" /db_xref="UniProtKB/Swiss-Prot:O31709" /translation="METNVEKNSGTATEKPSLFGVITSPSVQFERIRERPAVWGPLLI VAAIIIVGAVLQSLGTDYSELLKSQDTQGLSAEQMETVATITKFGGMAGAIIGGIAAL FIAPLIYWLCVKVSGGVTTYKKMLSLSLFVSLISSLGLLVNGIVAFTTDVNPLYSTTS LAGIIPSDGALASVLNTFEIFSIWSFVLLAIGLHKTGGISKKAGWISAIILFGILVVF SLFSGLINSVAGA*" gene 1503582..1504277 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" CDS 1504282..1505415 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11544226, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544226, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein" /protein_id="NP_389318.1" /db_xref="EnsemblGenomes-Gn:BSU14350" /db_xref="EnsemblGenomes-Tr:CAB13308" /db_xref="GOA:O31710" /db_xref="InterPro:IPR006143" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG13244" /db_xref="UniProtKB/Swiss-Prot:O31710" /translation="MKKVWIGIGIAVIVALFVGINIYRSAAPTSGSAGKEVQTGSVEE NEISSTVMVPGTLKFSNEQYVFYEADKGTLEDIKVKEGDKVKKGTALVTYTNEQLSLE KEQNQLTSESNRLQIDQIQEKLKALDSKERELEKQVGKKEAEKQIESERTELQMQKKT AEIELKQTELQRQSLANRVSDLEVKSEIEGTVISVNQEAASKKSDIQEPVIHIGNPKD LVVSGKLSEYDTLKVKKGQKVTLTSDVIQGKTWKGTVSAVGLVPDQQESAAAQGTEQA VQYPLQVKIKGNLPEGKPGFKFIMNIETDKRKANTLPSKAVKKEDDQYYVYTVKDGKA KRVDVKIGEVTDDLTEIKEGLTQDDQVILNPSDQVTDGMEVKS*" gene 1504282..1505415 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" CDS 1505416..1506108 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein (ATP-binding protein)" /protein_id="NP_389319.1" /db_xref="EnsemblGenomes-Gn:BSU14360" /db_xref="EnsemblGenomes-Tr:CAB13309" /db_xref="GOA:O31711" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13245" /db_xref="UniProtKB/Swiss-Prot:O31711" /translation="MIQLSNVRKSYQIGKETFDVLHSIDLDIHQGEYVSIMGPSGSGK STIMNIIGCLDRPTSGTYQLDGEDISSYKDKELAAVRNRSIGFVFQQFQLLPRLNAKK NVELPMIYSGIGKKERQERAERALEKVGLADRMLHMPNELSGGQKQRVAIARAIVNEP KLILADEPTGALDTKTSEAIMDQFTALNAEGTTIVLVTHEPEVADCTNRIVMVRDGNI VPASSGQRSVGE*" gene 1505416..1506108 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" CDS 1506105..1507298 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703, 22720735, 27243566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703, 22720735, 27243566; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease subunit exporting Sporulation-Delaying Protein" /protein_id="NP_389320.1" /db_xref="EnsemblGenomes-Gn:BSU14370" /db_xref="EnsemblGenomes-Tr:CAB13310" /db_xref="GOA:O31712" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR005085" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13246" /db_xref="UniProtKB/Swiss-Prot:O31712" /translation="MSLLENIRMALSSVLAHKMRSILTMLGIIIGVGSVIVVVAVGQG GEQMLKQSISGPGNTVELYYMPSDEELASNPNAAAESTFTENDIKGLKGIEGIKQVVA STSESMKARYHEEETDATVNGINDGYMNVNSLKIESGRTFTDNDFLAGNRVGIISQKM AKELFDKTSPLGEVVWINGQPVEIIGVLKKVTGLLSFDLSEMYVPFNMMKSSFGTSDF SNVSLQVESADDIKSAGKEAAQLVNDNHGTEDSYQVMNMEEIAAGIGKVTAIMTTIIG SIAGISLLVGGIGVMNIMLVSVTERTREIGIRKSLGATRGQILTQFLIESVVLTLIGG LVGIGIGYGGAALVSAIAGWPSLISWQVVCGGVLFSMLIGVIFGMLPANKAAKLDPIE ALRYE*" gene 1506105..1507298 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" downshifts 1507276 /Source="Nicolas_upshifts" /id="D800" /incds=0 /nref=79 /ntot=210 /MaxReadThrough="3.49546" /MaxDrop="4.46952" /score="36.2703425" /energy="-12.1" /TU="U1183" /idTUdmin="U1183" /TUdmin="-396" /isTUend="FALSE" promotor_-35 1507347..1507353 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1507367..1507378 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1507375 /Source="Nicolas_upshifts" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" promotor_-35 1507420..1507427 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-35" promotor_-10 1507442..1507461 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-10" S_feature 1507447..1507538 /Source="Nicolas_S_feature" /locus_tag="new_1507447_1507538" /HighExp="UNK1, LPh, HPh, Fru, G180, MG 5, C30, G135, MG t5, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigWXY" /TUshortPSig="0.967, 0.86, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S522" upshifts 1507447 /Source="Nicolas_upshifts" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" promotor_-35 1507502..1507509 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1507523..1507542 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1507540 /Source="Nicolas_upshifts" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" CDS 1507578..1508333 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563858; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (DeoR family)" /protein_id="NP_389321.1" /db_xref="EnsemblGenomes-Gn:BSU14380" /db_xref="EnsemblGenomes-Tr:CAB13311" /db_xref="GOA:O31713" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12589" /db_xref="UniProtKB/Swiss-Prot:O31713" /translation="MLTPERHQLIIDQIEKHDVVKIQELINLTNASESTIRRDLSTLE ERGFLKRVHGGAAKLSDIRLEPDMLEKSSKNLHDKLKIAEKAASLLEEGDCIYLDAGT TTLHMIDFMDKTKDIVVVTNGVMHIDALIRKEISFYLLGGYVKHRTGAIIGGASLVAM DQYRFDKSFLGTNGVHTEAGFTTPDPDEALLKQKAIKQAKHAYVLADPSKFGEISFSA FAGIGDATIITTDAEELTFDNYQEKTVVKVVKP*" gene 1507578..1508333 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" upshifts complement(1507726) /Source="Nicolas_upshifts" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1507728..1507730) /Source="Nicolas_upshift_promotors" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1507748) /Source="Nicolas_upshift_promotors" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1508330..1509241 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" /EC_number="2.7.1.56" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 168069, 14563858, 24328040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1-phosphate kinase" /protein_id="NP_389322.1" /db_xref="EnsemblGenomes-Gn:BSU14390" /db_xref="EnsemblGenomes-Tr:CAB13312" /db_xref="GOA:O31714" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR017583" /db_xref="InterPro:IPR022463" /db_xref="InterPro:IPR023314" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12588" /db_xref="UniProtKB/Swiss-Prot:O31714" /translation="MIYTVTLNPSVDYIVHVEDFTVGGLNRSSYDTKYPGGKGINVSR LLKRHHVASKALGFVGGFTGEYIKTFLREENLETAFSEVKGDTRINVKLKTGDETEIN GQGPTISDEDFKAFLEQFQSLQEGDIVVLAGSIPSSLPHDTYEKIAEACKQQNARVVL DISGEALLKATEMKPFLMKPNHHELGEMFGTAITSVEEAVPYGKKLVEQGAEHVIVSM AGDGALLFTNEAVYFANVPKGKLVNSVGAGDSVVAGFLAGISKQLPLEEAFRLGVTSG SATAFSEELGTEEFVQQLLPEVKVTRL*" gene 1508330..1509241 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" CDS 1509256..1511163 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" /EC_number="2.7.1.202" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:118007, 200418" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 118007, 200418; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIABC component" /protein_id="NP_389323.1" /db_xref="EnsemblGenomes-Gn:BSU14400" /db_xref="EnsemblGenomes-Tr:CAB13313" /db_xref="GOA:P71012" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003353" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004715" /db_xref="InterPro:IPR006327" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="PDB:2R4Q" /db_xref="SubtiList:BG11938" /db_xref="UniProtKB/Swiss-Prot:P71012" /translation="MKITELLTKHTIKLNIESKEKENVIDEMVTVLDKAGKLNDRQAY KEAILNRESQSSTGIGEGIAIPHAKTASVINPAIAFGRSKDGVDYESLDGQPAHLVFM IAATEGANNTHLEALSRLSTLLMREEIRKQLLEAESEDAIIDIINQHDKDDDEEEEEE EAAPAPAGKGKILAVTACPTGIAHTFMAADALKEKAKELGVEIKVETNGSSGIKHKLT AQEIEDAPAIIVAADKQVEMERFKGKRVLQVPVTAGIRRPQELIEKAMNQDAPIYQGS GGGSAASNDDEEAKGKSGSGIGNTFYKHLMSGVSNMLPFVVGGGILVAISFFWGIHSA DPNDPSYNTFAAALNFIGGDNALKLIVAVLAGFIAMSIADRPGFAPGMVGGFMATQAN AGFLGGLIAGFLAGYVVILLKKVFTFIPQSLDGLKPVLIYPLFGIFITGVLMQFVVNT PVAAFMNFLTNWLESLGTGNLVLMGIILGGMMAIDMGGPLNKAAFTFGIAMIDAGNYA PHAAIMAGGMVPPLGIALATTIFRNKFTQRDREAGITCYFMGAAFVTEGAIPFAAADP LRVIPAAVVGAAVAGGLTEFFRVTLPAPHGGVFVAFITNHPMLYLLSIVIGAVVMAII LGIVKKPVTEK*" gene 1509256..1511163 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" downshifts 1511148 /Source="Nicolas_upshifts" /id="D801" /incds=0 /nref=133 /ntot=228 /MaxReadThrough="3.99928" /MaxDrop="5.27169" /score="11.7516734" /energy="-11.4" /TU="U1185" /idTUdmin="U1186" /TUdmin=0 /isTUend="TRUE" promotor_-35 1511232..1511239 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1511250..1511269 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1511253 /Source="Nicolas_upshifts" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" CDS 1511308..1511889 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11283286, 11807061, 12897006, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11283286, 11807061, 12897006, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_389324.1" /db_xref="EnsemblGenomes-Gn:BSU14410" /db_xref="EnsemblGenomes-Tr:CAB13314" /db_xref="GOA:P71013" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11977" /db_xref="UniProtKB/Swiss-Prot:P71013" /translation="MTEEKNTNTEKTAKKKTNTYLEWGKAIVIAVLLALLIRHFLFEP YLVEGSSMYPTLHDGERLFVNKTVNYIGELKRGDIVIINGETSKIHYVKRLIGKPGET VQMKDDTLYINGKKVAEPYLSKNKKEAEKLGVSLTGDFGPVKVPKGKYFVMGDNRLNS MDSRNGLGLIAEDRIVGTSKFVFFPFNEMRQTK*" gene 1511308..1511889 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" downshifts 1511874 /Source="Nicolas_upshifts" /id="D802" /incds=0 /nref=90 /ntot=226 /MaxReadThrough="3.7981" /MaxDrop="6.13957" /score="5.03270493" /energy="-9.8" /TU="U1188" /idTUdmin="U1188" /TUdmin="-44" /isTUend="FALSE" downshifts 1511918 /Source="Nicolas_upshifts" /id="D803" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.6676" /MaxDrop="3.60225" /score="5.03270493" /energy="-9.8" /TU="NA" /idTUdmin="U1188" /TUdmin=0 /isTUend="TRUE" CDS complement(1511923..1512192) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389325.1" /db_xref="EnsemblGenomes-Gn:BSU14420" /db_xref="EnsemblGenomes-Tr:CAB13315" /db_xref="GOA:O31715" /db_xref="SubtiList:BG13247" /db_xref="UniProtKB/Swiss-Prot:O31715" /translation="MRLLTLTEYCLLIFFTGFYLAVTGFTAKDIGLYIGIALIYIFSH IFSKRLLEKRGKENKQVHLFFSVLAIIGSVFITVLCIALVASFSK*" gene complement(1511923..1512192) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" downshifts complement(1511928) /Source="Nicolas_upshifts" /id="D804" /incds=0 /nref=38 /ntot=254 /MaxReadThrough="2.08491" /MaxDrop="5.70938" /score="11.210199" /energy="-9.8" /TU="U1189" /idTUdmin="U1189" /TUdmin="-44" /isTUend="FALSE" S_feature complement(1512193..1512258) /Source="Nicolas_S_feature" /locus_tag="new_1512193_1512258_c" /HighExp="LoTm, Gly, Lbstat, Sw, Cold, C30, HPh, S0, T0.30H, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S523" misc_feature complement(1512239..1512258) /Source="Nicolas_upshift_promotors" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1512258) /Source="Nicolas_upshifts" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" promotor_-35 1512311..1512318 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1512329..1512348 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1512333 /Source="Nicolas_upshifts" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" CDS 1512373..1513995 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10816464, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_389326.1" /db_xref="EnsemblGenomes-Gn:BSU14430" /db_xref="EnsemblGenomes-Tr:CAB13316" /db_xref="GOA:O31716" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG13270" /db_xref="UniProtKB/Swiss-Prot:O31716" /translation="MIAVNNVSLRFADRKLFEDVNIKFTPGNCYGLIGANGAGKSTFL KVLSGEIEPQTGDVHMSPGERLAVLKQNHFEYEEYEVLKVVIMGHKRLYEVMQEKDAI YMKPDFSDEDGIRAAELEGEFAELNGWEAESEAAILLKGLGISEDLHTKKMADLGGSE KVKVLLAQALFGKPDVLLLDEPTNHLDLQAIQWLEEFLINFENTVIVVSHDRHFLNKV CTHIADLDFNKIQIYVGNYDFWYESSQLALKLSQEANKKKEEQIKQLQEFVARFSANA SKSKQATSRKKLLEKITLDDIKPSSRRYPYVNFTPEREIGNDVLRVEGLTKTIDGVKV LDNVSFIMNREDKIAFTGRNELAVTTLFKIISGEMEADSGTFKWGVTTSQAYFPKDNS EYFEGSDLNLVDWLRQYSPHDQSESFLRGFLGRMLFSGEEVHKKANVLSGGEKVRCML SKAMLSGANILILDEPTNHLDLESITALNNGLISFKGAMLFTSHDHQFVQTIANRIIE ITPNGIVDKQMSYDEFLENADVQKKLTELYAE*" gene 1512373..1513995 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" downshifts 1513983 /Source="Nicolas_upshifts" /id="D805" /incds=0 /nref=45 /ntot=239 /MaxReadThrough="5.13671" /MaxDrop="3.6227" /score="17.6386925" /energy="-7.6" /TU="U1190" /idTUdmin="U1190" /TUdmin="-993" /isTUend="FALSE" CDS 1514052..1514963 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 15966718, 17229734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate reductase" /protein_id="NP_389327.1" /db_xref="EnsemblGenomes-Gn:BSU14440" /db_xref="EnsemblGenomes-Tr:CAB13317" /db_xref="GOA:O31717" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13271" /db_xref="UniProtKB/Swiss-Prot:O31717" /translation="MKFLVVGAGGVGGYIGGRLSEKGNDVTFLVRQKRAEQLKKTGLV IHSEKGNVSFQPELISAGETGQFDVVIIASKAYSLGQVIEDVKPFIHQESVIIPFLNG YRHYEQLFAAFSKEQVLGGLCFIESALDNKGEIHHTSASHRFVFGEWNGERTERIRAL EEAFSGVKAEVIISGHIEKDIWKKYLFIAAQAGITTLFQRPLGPILATEAGRHTAQTL IGEICTVLRKEGVPADPALEEESFRTMTSMSYHMKSSMLRDMENGQTTEGDHLHGFLI EKAKRLSLAAPVLETVYANLQMYEAEK*" gene 1514052..1514963 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" downshifts 1514968 /Source="Nicolas_upshifts" /id="D806" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="2.04919" /MaxDrop="4.55439" /score="11.4959806" /energy="-9.6" /TU="NA" /idTUdmin="U1190" /TUdmin="-8" /isTUend="TRUE" CDS complement(1514997..1516229) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" /EC_number="3.4.11.24" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9362117, 16088219, 22808738" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9362117, 16088219, 22808738; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase" /protein_id="NP_389328.1" /db_xref="EnsemblGenomes-Gn:BSU14450" /db_xref="EnsemblGenomes-Tr:CAB13318" /db_xref="GOA:P39762" /db_xref="InterPro:IPR000787" /db_xref="InterPro:IPR035097" /db_xref="SubtiList:BG10986" /db_xref="UniProtKB/Swiss-Prot:P39762" /translation="MDSFSQKLNTYAQLAVEVGVNVQKGQYVVVNASTDVRDFVRLIV KHAYEKGAKNVTVNWQDDEVAKLKYELAPFEAFEEYPEWEAKGREELAKNGAAFISVV SSNPDLLKGIDSKRIAAFQKAAGKALHTYRQYIQSDKVSWTVVGAASAGWAHKVFPGK SEEEAIHLLWEEIFKATRVNEDNPVQAWINHDQNLHEKVDHLNERHYAALHYQAEGTD LTIKLPRKHVWAGAGSVNESGHEFMANMPTEEVFTLPQKDGVDGVVSSTKPLSYGGNI IENFTLTFENGRIVDIKAEKGEDILKELVETDEGSHYLGEVALVPYDSPISQSNILFY NTLFDENASNHLAIGSAYAFNIEGGKQMSREELVKEGLNESITHVDFMIGSKDMNIDG ITADGKREPIFRNGNWAF*" gene complement(1514997..1516229) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" downshifts complement(1515008) /Source="Nicolas_upshifts" /id="D807" /incds=0 /nref=215 /ntot=254 /MaxReadThrough="1.34101" /MaxDrop="5.7635" /score="40.7811053" /energy="-9.6" /TU="NA" /idTUdmin="U1191" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1516247..1516266) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1516271) /Source="Nicolas_upshifts" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" promotor_-35 complement(1516281..1516286) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1516339..1516473) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389329.1" /db_xref="EnsemblGenomes-Gn:BSU14460" /db_xref="EnsemblGenomes-Tr:CAB13319" /db_xref="InterPro:IPR035379" /db_xref="SubtiList:BG11812" /db_xref="UniProtKB/Swiss-Prot:Q45492" /translation="MLRDLGRRVAIAAILSGIILGGMSISLANMPHSPAGGTVKLNHP *" gene complement(1516339..1516473) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" downshifts complement(1516350) /Source="Nicolas_upshifts" /id="D808" /incds=0 /nref=51 /ntot=151 /MaxReadThrough="3.10365" /MaxDrop="5.04142" /score="-2.2377884" /energy="-9.1" /TU="U1192" /idTUdmin="U1193" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1516495..1516513) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1516506) /Source="Nicolas_upshifts" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" S_feature complement(1516508..1516573) /Source="Nicolas_S_feature" /locus_tag="new_1516508_1516573_c" /HighExp="HiTm, C30, Lbstat, MG-0.2, BC, G135, MG 15, MG 10, MG-0.1, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S524" promotor_-35 complement(1516529..1516534) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1516574..1517581) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16950129, 19643765, 19659933, 21091501, 21636651, 26091431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950129, 19643765, 19659933, 21091501, 21636651, 26091431; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_389330.1" /db_xref="EnsemblGenomes-Gn:BSU14470" /db_xref="EnsemblGenomes-Tr:CAB13320" /db_xref="GOA:P39763" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10987" /db_xref="UniProtKB/Swiss-Prot:P39763" /translation="MFQSTEIGIDLGTANILVYSKNKGIILNEPSVVAVDTTTKAVLA IGADAKNMIGKTPGKIVAVRPMKDGVIADYDMTTDLLKHIMKKAAKSIGMSFRKPNVV VCTPSGSTAVERRAISDAVKNCGAKNVHLIEEPVAAAIGADLPVDEPVANVVVDIGGG TTEVAIISFGGVVSCHSIRIGGDQLDEDIVSFVRKKYNLLIGERTAEQVKMEIGHALI EHIPEAMEIRGRDLVTGLPKTIMLQSNEIQDAMRESLLHILEAIRATLEDCPPELSGD IVDRGVILTGGGALLNGIKEWLTEEIVVPVHVAQNPLESVAIGTGRSLEVIDKLQKAI K*" gene complement(1516574..1517581) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" upshifts complement(1517627) /Source="Nicolas_upshifts" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" promotor_-10 complement(1517628..1517636) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1517650..1517658) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1517768..1517777 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-35" upshifts 1517789 /Source="Nicolas_upshifts" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" promotor_-10 1517790..1517805 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-10" S_feature 1517792..1517864 /Source="Nicolas_S_feature" /locus_tag="new_1517792_1517864" /HighExp="Lbexp, dia5, LBGexp, dia0, Lbtran, Mt0, Oxctl, Paraq, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S525" CDS 1517865..1518143 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16159768, 17720793, 19767430, 20817675, 20844865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159768, 17720793, 19767430, 20817675, 20844865; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389331.1" /db_xref="EnsemblGenomes-Gn:BSU14480" /db_xref="EnsemblGenomes-Tr:CAB13321" /db_xref="GOA:P39758" /db_xref="InterPro:IPR007159" /db_xref="PDB:2FY9" /db_xref="PDB:2RO3" /db_xref="SubtiList:BG10988" /db_xref="UniProtKB/Swiss-Prot:P39758" /translation="MKSIGVVRKVDELGRIVMPIELRRALDIAIKDSIEFFVDGDKII LKKYKPHGVCLMTGEITSENKEYGNGKITLSPEGAQLLLEEIQAALKE*" gene 1517865..1518143 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" downshifts 1518141 /Source="Nicolas_upshifts" /id="D809" /incds=0 /nref=61 /ntot=238 /MaxReadThrough="4.68201" /MaxDrop="5.62457" /score="7.91393519" /energy="-11" /TU="U1194" /idTUdmin="U1194" /TUdmin="-135" /isTUend="FALSE" S_feature complement(1518175..1519804) /Source="Nicolas_S_feature" /locus_tag="new_1518175_1519804_c" /HighExp="S6, S8, S5, LoTm, S4, S7, S3, C30, T5.0H, BT" /AntisenseName="kinC" /AntisenseCor="-0.76370141168998495" /AntisenseRegPval="-51.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S526" S_feature 1518186..1518290 /Source="Nicolas_S_feature" /locus_tag="new_1518186_1518290" /HighExp="Oxctl, Lbexp, LBGexp, H2O2, dia0, Paraq, G180, G150, G135, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S527" downshifts complement(1518198) /Source="Nicolas_upshifts" /id="D810" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.833919999999999" /MaxDrop="3.11258" /score="8.02057524" /energy="-11" /TU="NA" /idTUdmin="U1196" /TUdmin=0 /isTUend="TRUE" promotor_-35 1518272..1518279 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1518291..1518310 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1518292 /Source="Nicolas_upshifts" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" CDS 1518333..1519619 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" /EC_number="2.7.13.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-responsive histidine kinase regulating cannibalism and biofilm formation" /protein_id="NP_389332.1" /db_xref="EnsemblGenomes-Gn:BSU14490" /db_xref="EnsemblGenomes-Tr:CAB13322" /db_xref="GOA:P39764" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10989" /db_xref="UniProtKB/Swiss-Prot:P39764" /translation="MRKYQARIISIILAMIFIMFWDYLFYFIGKNPINWPVDIVYTAV TLVSVWMLAYYIDEKQQLVKKMKDNEWKYKQLSEEKNRIMDNLQEIVFQTNAKGEITY LNQAWASITGFSISECMGTMYNDYFIKEKHVADHINTQIQNKASSGMFTAKYVTKNGT IFWGEVHYKLYYDRDDQFTGSLGTMSDITERKEAEDELIEINERLARESQKLSITSEL AAGIAHEVRNPLTSVSGFLQIMKTQYPDRKDYFDIIFSEIKRIDLVLSELLLLAKPQA ITFKTHQLNEILKQVTTLLDTNAILSNIVIEKNFKETDGCMINGDENQLKQVFINIIK NGIEAMPKGGVVTISTAKTASHAVISVKDEGNGMPQEKLKQIGKPFYSTKEKGTGLGL PICLRILKEHDGELKIESEAGKGSVFQVVLPLKSDS*" gene 1518333..1519619 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" CDS 1519635..1520468 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" /EC_number="2.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28537416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative gamma-glutamylcyclotransferase (bacillithiol degradation)" /protein_id="NP_389333.1" /db_xref="EnsemblGenomes-Gn:BSU14500" /db_xref="EnsemblGenomes-Tr:CAB13323" /db_xref="GOA:P39759" /db_xref="InterPro:IPR009288" /db_xref="InterPro:IPR013024" /db_xref="InterPro:IPR036568" /db_xref="PDB:2QIK" /db_xref="SubtiList:BG10990" /db_xref="UniProtKB/Swiss-Prot:P39759" /translation="MNSLLFVYGTLRKHEKNHHLLAQSACINEQARTKGSLFAAKEGP TVVFNDEDEGYIYGEVYEADELCIHKLDQFFQGYHKQTVFVETDVGIKIALIYFMNKD GCAGFTKISSGDWKEHQMISKSKNPIYYFAYGSCMDNARFQKAGVDHYFQDPVGRAVL KGYTTRFTLKREDGSRADMLEDGGTTEGVLYRIPYSALSYLYKREGVESLTYRPAFVD VEAGGRHYKDCLTFLVLQKEAEIAPPQHYQIEIERGAELYLSPEFTEKLKRHMNSLPK G*" gene 1519635..1520468 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" promotor_-10 complement(1519801..1519819) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1519816) /Source="Nicolas_upshifts" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" promotor_-35 complement(1519835..1519840) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1520531..1521196 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 22720735, 23963175, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 22720735, 23963175, 28420751; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_389334.1" /db_xref="EnsemblGenomes-Gn:BSU14510" /db_xref="EnsemblGenomes-Tr:CAB13324" /db_xref="GOA:P39760" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG10991" /db_xref="UniProtKB/Swiss-Prot:P39760" /translation="MKKEFAVIGLGRFGGSICKALSEEGVEVMAMDIDEDKVNEYAKI ASHAVIGDSTDESVLKNLGLRNFDHVIVAIGENIQASILTTLILKELGVHTITVKAQN DYHEKVLSKIGADHIVHPERDMAKRIAHNIVSNNVLDYLELSEEHSLVEIVANSRLAG NTLLDLDIRAKYGINIVAIKRGKEVIVSPLATEVIHQEDILIVIGSVTDISRFEKRVL HTK*" gene 1520531..1521196 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" downshifts 1521180 /Source="Nicolas_upshifts" /id="D811" /incds=0 /nref=191 /ntot=256 /MaxReadThrough="3.15176" /MaxDrop="5.50828" /score="4.60161255" /energy="-8.2" /TU="U1195" /idTUdmin="U1195" /TUdmin="-22" /isTUend="TRUE" promotor_-35 1521287..1521293 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1521308..1521327) /Source="Nicolas_upshift_promotors" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1521308..1521327 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1521320 /Source="Nicolas_upshifts" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" upshifts complement(1521322) /Source="Nicolas_upshifts" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1521351..1523084 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 8550522, 17183219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 8550522, 17183219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine deaminase" /protein_id="NP_389335.2" /db_xref="EnsemblGenomes-Gn:BSU14520" /db_xref="EnsemblGenomes-Tr:CAB13325" /db_xref="GOA:P39761" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11044" /db_xref="UniProtKB/Swiss-Prot:P39761" /translation="MNKEALVNRLNASAKRQKADIVIKNGKIMDVYNQEWIYEDIAIT DGVIVGLGEYEGENIIDAEGQMIVPGFIDGHVHIESSMVTPIEFAKAVLPHGVTTVVT DPHEIANVSGEKGIEFMLEQARHTPLNIHFMLPSSVPAASFERSGAILKAADLKPFYE EEEVLGLAEVMDYVSVQQAEKDMVQKLLDARVAGKRIDGHLAGLSTDLINIYRTAFVL NDHEVTSKEEALDRIRRGMYVMMREGSVAKNTLNVLPAVNEKNARRFFFCTDDKHVDD LLSEGSVNHQVKMAIQAGLNPFLAYQLGSLNAAECYGLDTKGAIAPGFDADLLFVSDL ENVTVTMTMVKGQTVAEDSKAVYQDHASTAAPDQALLDSVKLAAPLNKQDFHMPIDSE QQINVIQIIPNQLETRLVQVPAPVAREFEPDTELDLLKIAVVERHKGLKETGLGVVKG FGFKSGAIATTISHDSHNIIAVGTNDEDIAAAVNKLQEIGGGLTIIKNGEELHSVPLP IAGLLSDQSAEQVNQSLLTLHDKLSLIGFTGGFNPFLTLSFLALPVIPDIKMTTTGLF DVKSFQHISLQ*" gene 1521351..1523084 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" S_feature complement(1522479..1523083) /Source="Nicolas_S_feature" /locus_tag="new_1522479_1523083_c" /HighExp="Etha, C30, C90, dia15, LBGexp, Cold, dia5, S8, G180, S7" /AntisenseName="adeC" /AntisenseCor="-9.8927927273806792E-3" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S528" downshifts 1523073 /Source="Nicolas_upshifts" /id="D812" /incds=0 /nref=51 /ntot=223 /MaxReadThrough="1.93923" /MaxDrop="6.63088" /score="44.3452043" /energy="-19.5" /TU="NA" /idTUdmin="U1197" /TUdmin="-21" /isTUend="TRUE" CDS complement(1523118..1524785) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease J1" /protein_id="NP_389336.1" /db_xref="EnsemblGenomes-Gn:BSU14530" /db_xref="EnsemblGenomes-Tr:CAB13326" /db_xref="GOA:Q45493" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR001587" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="PDB:3ZQ4" /db_xref="SubtiList:BG11813" /db_xref="UniProtKB/Swiss-Prot:Q45493" /translation="MKFVKNDQTAVFALGGLGEIGKNTYAVQFQDEIVLIDAGIKFPE DELLGIDYVIPDYTYLVKNEDKIKGLFITHGHEDHIGGIPYLLRQVNIPVYGGKLAIG LLRNKLEEHGLLRQTKLNIIGEDDIVKFRKTAVSFFRTTHSIPDSYGIVVKTPPGNIV HTGDFKFDFTPVGEPANLTKMAEIGKEGVLCLLSDSTNSENPEFTMSERRVGESIHDI FRKVDGRIIFATFASNIHRLQQVIEAAVQNGRKVAVFGRSMESAIEIGQTLGYINCPK NTFIEHNEINRMPANKVTILCTGSQGEPMAALSRIANGTHRQISINPGDTVVFSSSPI PGNTISVSRTINQLYRAGAEVIHGPLNDIHTSGHGGQEEQKLMLRLIKPKFFMPIHGE YRMQKMHVKLATDCGIPEENCFIMDNGEVLALKGDEASVAGKIPSGSVYIDGSGIGDI GNIVLRDRRILSEEGLVIVVVSIDMDDFKISAGPDLISRGFVYMRESGDLINDAQELI SNHLQKVMERKTTQWSEIKNEITDTLAPFLYEKTKRRPMILPIIMEV*" gene complement(1523118..1524785) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" downshifts complement(1523128) /Source="Nicolas_upshifts" /id="D813" /incds=0 /nref=149 /ntot=269 /MaxReadThrough="4.3738" /MaxDrop="8.12983" /score="37.2074215" /energy="-19.5" /TU="U1199" /idTUdmin="U1200" /TUdmin="-2" /isTUend="TRUE" CDS complement(1524791..1525000) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" /function="9.2: DNA-dependent RNA polymerase" /experiment="publication(s) with functional evidences, PMID:18289874, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18289874, 24187087; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega 1 subunit of RNA polymerase" /protein_id="NP_389337.1" /db_xref="EnsemblGenomes-Gn:BSU14540" /db_xref="EnsemblGenomes-Tr:CAB13327" /db_xref="InterPro:IPR009907" /db_xref="SubtiList:BG13335" /db_xref="UniProtKB/Swiss-Prot:O31718" /translation="MIYKVFYQEKADEVPVREKTDSLYIEGVSERDVRTKLKEKKFNI EFITPVDGAFLEYEQQSENFKVLEL*" gene complement(1524791..1525000) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" promotor_-10 complement(1525037..1525056) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1525059) /Source="Nicolas_upshifts" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" S_feature complement(1525061..1525238) /Source="Nicolas_S_feature" /locus_tag="new_1525061_1525238_c" /HighExp="S5, S8, S7, S6, S4, ferm, nit, T5.0H, HiTm, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97062099999999996" /TUshortSig="SigGF" /TUshortPSig="0.828" /TUlongSig="NA" /TUlongPSig="NA" /label="S529" promotor_-35 complement(1525071..1525074) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1525239) /Source="Nicolas_upshifts" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" promotor_-10 complement(1525241..1525252) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1525266..1525272) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1525311..1525318 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1525332..1525351 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1525348 /Source="Nicolas_upshifts" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" CDS 1525386..1526159 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389338.1" /db_xref="EnsemblGenomes-Gn:BSU14550" /db_xref="EnsemblGenomes-Tr:CAB13328" /db_xref="GOA:Q45494" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11814" /db_xref="UniProtKB/Swiss-Prot:Q45494" /translation="MDSKLIFFDIDGTIYDHDKNIPESTRKTVAELQRQGHHVFIASG RSPFLVKPILEELGIHSFISYNGQFVVFENQVIYKNPLPENAIRRLLKQADEGKHPVV FMAEDTMKATVADHPHVLEGIGSLKTDYPETDDLFYEGKEIFQLLLFCQDEEEKAYAA FPEFDLVRWHELSTDVLPHGGSKAEGIKKVIERLPFDIGDTYAFGDGLNDLQMIEYVG TGVAMGNAVPELKEIADFVTKPVDEDGIAYAVKELGLLK*" gene 1525386..1526159 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" downshifts 1526130 /Source="Nicolas_upshifts" /id="D814" /incds=0 /nref=184 /ntot=249 /MaxReadThrough="2.83896" /MaxDrop="6.20802" /score="28.5519453" /energy="-15.4" /TU="U1201" /idTUdmin="U1201" /TUdmin="-22" /isTUend="TRUE" CDS complement(1526195..1526749) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11429456, 16207374, 23944997, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16207374, 23944997, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-cysteine deformylase (promiscuous)" /protein_id="NP_389339.1" /db_xref="EnsemblGenomes-Gn:BSU14560" /db_xref="EnsemblGenomes-Tr:CAB13329" /db_xref="GOA:Q45495" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11815" /db_xref="UniProtKB/Swiss-Prot:Q45495" /translation="MITMENIVRDGHPALRETAEPVELPPTDAEKQQLADMIEFVKNS QNPELAEKYKLRPGVGLAAPQINIKKRMIAVHAEDASGKLYSYALFNPKIVSHSVEKS YLTSGEGCLSVDEAIPGYVPRYARIRVKGTTLEGENIDIRLKGFPAIVFQHEIDHLNG VMFYDHIDKENPFKEPENAIAIER*" gene complement(1526195..1526749) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" downshifts complement(1526206) /Source="Nicolas_upshifts" /id="D815" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="1.87469" /MaxDrop="5.89844" /score="28.3817715" /energy="-15.4" /TU="NA" /idTUdmin="U1202" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1526771..1526790) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1526781) /Source="Nicolas_upshifts" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" promotor_-35 complement(1526805..1526812) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1526834 /Source="Nicolas_upshifts" /id="D816" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="0.95601" /MaxDrop="4.18336" /score="0.455865843" /energy="-17.1" /TU="NA" /idTUdmin="U1201" /TUdmin=682 /isTUend="FALSE" downshifts complement(1526858) /Source="Nicolas_upshifts" /id="D817" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.11854" /MaxDrop="8.20445" /score="-8.94821426" /energy="-15.3" /TU="NA" /idTUdmin="U1204" /TUdmin="-14" /isTUend="TRUE" CDS complement(1526859..1527017) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin (toxin I motif)" /protein_id="YP_003097725.1" /db_xref="EnsemblGenomes-Gn:BSU14569" /db_xref="EnsemblGenomes-Tr:CAX52616" /db_xref="GOA:C0H409" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H409" /translation="MYGYGYGGGCCSYGGYGYGGCGYGYGRTFALIVVLFILLIIVGA AYLGGGCC*" gene complement(1526859..1527017) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" CDS complement(1526924..1527067) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin" /protein_id="YP_009513955.1" /db_xref="EnsemblGenomes-Gn:BSU14568" /db_xref="EnsemblGenomes-Tr:CCQ48596" /db_xref="UniProtKB/TrEMBL:L8E9Z2" /translation="MPTYKGSGVIKRGGYVICMDMVTAEAAAVMVVTDMVAADMATAA PLR*" gene complement(1526924..1527067) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" promotor_-35 1527013..1527017 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1527018..1527086) /Source="Nicolas_S_feature" /locus_tag="new_1527018_1527086_c" /HighExp="S8, S7, BT, S6, G/S, B36, Pyr, S5, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S530" promotor_-10 1527027..1527041 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1527054 /Source="Nicolas_upshifts" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1527070..1527089) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1527099) /Source="Nicolas_upshifts" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" promotor_-35 complement(1527102..1527111) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1527173..1527180 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1527194..1527213 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1527198 /Source="Nicolas_upshifts" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" CDS 1527231..1527902 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16684363, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389340.2" /db_xref="EnsemblGenomes-Gn:BSU14570" /db_xref="EnsemblGenomes-Tr:CAB13330" /db_xref="GOA:P21884" /db_xref="InterPro:IPR019454" /db_xref="InterPro:IPR036785" /db_xref="SubtiList:BG10206" /db_xref="UniProtKB/Swiss-Prot:P21884" /translation="MKDAIKRRPGIKIGAFCAMALILTGCMGQDPVDSLHHSLEKAAE SEKPFQEEQNTLKELEAKENQLYDSVMKLNMDDYKKIVALSNKALENVSKREEHLKLE NDSMKKSETEFEEAKTSAEHIKEKDIKEKADAAANHMEKRYTSYGTMYKEYKKALELN KKLYMQLKDKDLTRDDLDQQIDKVNASYEKILKYSGEFNEQTEKYNKAREDLYDAAGY RVKKS*" gene 1527231..1527902 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" promotor_-35 1527570..1527579 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1527592..1527610 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1527604 /Source="Nicolas_upshifts" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1527849 /Source="Nicolas_upshifts" /id="D818" /incds=0 /nref=96 /ntot=244 /MaxReadThrough="3.9299" /MaxDrop="6.03956" /score="20.6110953" /energy="-9.9" /TU="U1205" /idTUdmin="U1206" /TUdmin=3 /isTUend="TRUE" promotor_-35 1528077..1528082 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1528099..1528118 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1528100..1528325 /Source="Nicolas_S_feature" /locus_tag="new_1528100_1528325" /HighExp="nit, MG-0.1, Diami, MG-0.2, ferm, dia5, Lbexp, dia0, Paraq, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S531" upshifts 1528100 /Source="Nicolas_upshifts" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" misc_feature complement(1528104..1528123) /Source="Nicolas_upshift_promotors" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1528120) /Source="Nicolas_upshifts" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1528224..1528232) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1528230) /Source="Nicolas_upshifts" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1528246..1528254) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1528326..1529441 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" /EC_number="1.2.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 alpha subunit)" /protein_id="NP_389341.1" /db_xref="EnsemblGenomes-Gn:BSU14580" /db_xref="EnsemblGenomes-Tr:CAB13331" /db_xref="GOA:P21881" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR017596" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10207" /db_xref="UniProtKB/Swiss-Prot:P21881" /translation="MAAKTKKAIVDSKKQFDAIKKQFETFQILNEKGEVVNEAAMPDL TDDQLKELMRRMVFTRVLDQRSISLNRQGRLGFYAPTAGQEASQIATHFALEKEDFVL PGYRDVPQLIWHGLPLYQAFLFSRGHFRGNQMPDDVNALSPQIIIGAQYIQTAGVALG LKKRGKKAVAITYTGDGGASQGDFYEGINFAGAYKAPAIFVVQNNRYAISTPVEKQSA AETIAQKAVAAGIVGVQVDGMDPLAVYAATAEARERAINGEGPTLIETLTFRYGPHTM AGDDPTKYRTKEIENEWEQKDPLVRFRAFLENKGLWSEEEEAKVIEDAKEEIKQAIKK ADAEPKQKVTDLMKIMYEKMPHNLEEQFEIYTQKESK*" gene 1528326..1529441 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" CDS 1529445..1530422 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" /EC_number="1.2.4.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 9891797, 10735853, 11976308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 9891797, 10735853, 11976308; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 beta subunit)" /protein_id="NP_389342.1" /db_xref="EnsemblGenomes-Gn:BSU14590" /db_xref="EnsemblGenomes-Tr:CAB13332" /db_xref="GOA:P21882" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10208" /db_xref="UniProtKB/Swiss-Prot:P21882" /translation="MAQMTMIQAITDALRTELKNDENVLVFGEDVGVNGGVFRATEGL QKEFGEDRVFDTPLAESGIGGLALGLGLNGFRPVMEIQFFGFVYEVMDSVSGQMARMR YRSGGRWTSPVTIRSPFGGGVHTPELHADSLEGLVAQQPGIKVVIPSTPYDAKGLLIS AIRDNDPVVFLEHMKLYRSFRQEVPEEEYTIELGKADVKREGTDLSIITYGAMVHESL KAADELEKDGISAEVVDLRTVSPLDIDTIIASVEKTGRAIVVQEAQKQAGIAANVVAE INDRAILSLEAPVLRVAAPDTVFPFSQAESVWLPNHKDVLETARKVLEF*" gene 1529445..1530422 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" S_feature 1530423..1530536 /Source="Nicolas_S_feature" /locus_tag="new_1530423_1530536" /HighExp="G150, LBGexp, MG-0.1, G180, C30, Diami, Oxctl, G135, ferm, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S532" promotor_-10 complement(1530457..1530476) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1530474) /Source="Nicolas_upshifts" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1530491..1530494) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1530537..1531865 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" /EC_number="2.3.1.12" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (dihydrolipoamide acetyltransferase E2 subunit)" /protein_id="NP_389343.1" /db_xref="EnsemblGenomes-Gn:BSU14600" /db_xref="EnsemblGenomes-Tr:CAB13333" /db_xref="GOA:P21883" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10209" /db_xref="UniProtKB/Swiss-Prot:P21883" /translation="MAFEFKLPDIGEGIHEGEIVKWFVKPNDEVDEDDVLAEVQNDKA VVEIPSPVKGKVLELKVEEGTVATVGQTIITFDAPGYEDLQFKGSDESDDAKTEAQVQ STAEAGQDVAKEEQAQEPAKATGAGQQDQAEVDPNKRVIAMPSVRKYAREKGVDIRKV TGSGNNGRVVKEDIDSFVNGGAQEAAPQETAAPQETAAKPAAAPAPEGEFPETREKMS GIRKAIAKAMVNSKHTAPHVTLMDEVDVTNLVAHRKQFKQVAADQGIKLTYLPYVVKA LTSALKKFPVLNTSIDDKTDEVIQKHYFNIGIAADTEKGLLVPVVKNADRKSVFEISD EINGLATKAREGKLAPAEMKGASCTITNIGSAGGQWFTPVINHPEVAILGIGRIAEKA IVRDGEIVAAPVLALSLSFDHRMIDGATAQNALNHIKRLLNDPQLILMEA*" gene 1530537..1531865 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" promotor_-35 1530681..1530688 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1530703..1530722 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1530706 /Source="Nicolas_upshifts" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" CDS 1531870..1533282 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" /EC_number="1.8.1.4" /EC_number="1.2.1.25" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 6815422, 9352926, 9588797, 12682299, 21856851" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 6815422, 9352926, 9588797, 12682299, 21856851; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="dihydrolipoamide dehydrogenase E3 subunit of both pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes" /protein_id="NP_389344.1" /db_xref="EnsemblGenomes-Gn:BSU14610" /db_xref="EnsemblGenomes-Tr:CAB13334" /db_xref="GOA:P21880" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10210" /db_xref="UniProtKB/Swiss-Prot:P21880" /translation="MVVGDFPIETDTLVIGAGPGGYVAAIRAAQLGQKVTVVEKATLG GVCLNVGCIPSKALINAGHRYENAKHSDDMGITAENVTVDFTKVQEWKASVVNKLTGG VAGLLKGNKVDVVKGEAYFVDSNSVRVMDENSAQTYTFKNAIIATGSRPIELPNFKYS ERVLNSTGALALKEIPKKLVVIGGGYIGTELGTAYANFGTELVILEGGDEILPGFEKQ MSSLVTRRLKKKGNVEIHTNAMAKGVEERPDGVTVTFEVKGEEKTVDADYVLITVGRR PNTDELGLEQVGIEMTDRGIVKTDKQCRTNVPNIYAIGDIIEGPPLAHKASYEGKIAA EAIAGEPAEIDYLGIPAVVFSEPELASVGYTEAQAKEEGLDIVAAKFPFAANGRALSL NETDGFMKLITRKEDGLVIGAQIAGASASDMISELSLAIEGGMTAEDIAMTIHAHPTL GEITMEAAEVAIGSPIHIVK*" gene 1531870..1533282 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" downshifts 1533279 /Source="Nicolas_upshifts" /id="D819" /incds=0 /nref=241 /ntot=268 /MaxReadThrough="1.82289" /MaxDrop="9.27853" /score="33.2247807" /energy="-12.1" /TU="NA" /idTUdmin="U1207" /TUdmin="-1" /isTUend="TRUE" CDS complement(1533327..1533701) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1936936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1936936; Product type s : structure" /codon_start=1 /transl_table=11 /product="small peptidoglycan-associated lipoprotein" /protein_id="NP_389345.1" /db_xref="EnsemblGenomes-Gn:BSU14620" /db_xref="EnsemblGenomes-Tr:CAB13335" /db_xref="GOA:P39910" /db_xref="SubtiList:BG10211" /db_xref="UniProtKB/Swiss-Prot:P39910" /translation="MRYRAVFPMLIIVFALSGCTLSTINPMKKSRIDNIHHTQILFFS DENQIDQEAPYYDALLDLEKDYPEQIDKMKVYDKKEGWEDEIETVPTLMVVDQRHVVV KIEGCVKKKEDIIKPLQHVLSK*" gene complement(1533327..1533701) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" downshifts complement(1533375) /Source="Nicolas_upshifts" /id="D820" /incds=0 /nref=26 /ntot=132 /MaxReadThrough="1.54024" /MaxDrop="3.69756" /score="4.23955997" /energy="-12.1" /TU="NA" /idTUdmin="U1212" /TUdmin=3 /isTUend="TRUE" misc_feature complement(1533732..1533751) /Source="Nicolas_upshift_promotors" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1533742) /Source="Nicolas_upshifts" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" promotor_-35 1533905..1533910 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-35" promotor_-10 1533926..1533944 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-10" upshifts 1533936 /Source="Nicolas_upshifts" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" S_feature 1533940..1534049 /Source="Nicolas_S_feature" /locus_tag="new_1533940_1534049" /HighExp="S4, S5, S7, S6, S8, S3, BT, G/S, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S533" downshifts complement(1533972) /Source="Nicolas_upshifts" /id="D821" /incds=0 /nref=4 /ntot=18 /MaxReadThrough="1.96608" /MaxDrop="3.4036" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=308 /isTUend="FALSE" promotor_-35 1534033..1534040 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1534051 /Source="Nicolas_upshifts" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" promotor_-10 1534055..1534074 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1534070..1534280 /gene="srrA" /locus_tag="BSU_misc_RNA_70" /product="small regulatory RNA and messenger RNA (argininemetabolism)" /experiment="publication(s) with functional evidences, PMID:16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348; Product type n: RNA" /function="16.3: Control" gene 1534070..1534280 /gene="srrA" /locus_tag="BSU_misc_RNA_70" CDS 1534120..1534239 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16164558, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 20444087, 27449348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of GapA synthesis" /protein_id="YP_003097726.1" /db_xref="EnsemblGenomes-Gn:BSU14629" /db_xref="EnsemblGenomes-Tr:CAX52617" /db_xref="InterPro:IPR025236" /db_xref="UniProtKB/Swiss-Prot:C0H410" /translation="MGTIVCQDCNEAIHYFEDEKVTTLYGTCCGQCQCPVDEE*" gene 1534120..1534239 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" downshifts complement(1534126) /Source="Nicolas_upshifts" /id="D822" /incds=0 /nref=6 /ntot=35 /MaxReadThrough="3.43398" /MaxDrop="4.36472" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=154 /isTUend="FALSE" downshifts 1534226 /Source="Nicolas_upshifts" /id="D823" /incds=0 /nref=59 /ntot=171 /MaxReadThrough="5.69396" /MaxDrop="7.24152" /score="51.2534618" /energy="-16.8" /TU="U1214" /idTUdmin="U1213" /TUdmin=0 /isTUend="TRUE" S_feature 1534271..1535874 /Source="Nicolas_S_feature" /locus_tag="new_1534271_1535874" /HighExp="M9-stat, M0t90, B60, M40t90, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T0.30H" /AntisenseName="speA" /AntisenseCor="-0.33575411980382203" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.998" /label="S534" CDS complement(1534279..1535751) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" /EC_number="4.1.1.19" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 19114526, 19255484, 20876533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 19114526, 19255484, 20876533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine decarboxylase" /protein_id="NP_389346.1" /db_xref="EnsemblGenomes-Gn:BSU14630" /db_xref="EnsemblGenomes-Tr:CAB13336" /db_xref="GOA:P21885" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10212" /db_xref="UniProtKB/Swiss-Prot:P21885" /translation="MSQHETPLYTGLKKHASRQPVQFHIPGHKKGAGMDPEFRQFIGE NALSIDLINIEPLDDLHAPKGIIKQAQDLAAEAFGADHTFFSVQGTSGAIMTMVMAVC GPGDKIIIPRNVHKSIMTAIVFSGAVPIFIHPEIDNELGISHGITLESAKRALTEHPD AKGLLVINPTYFGVAADLKSIVELAHSFDVPVLVDEAHGVHIHFHDELPLSAMQAGAD IAATSVHKLGGSLTQSSILNMREGLVSKDRVQSILSMLTTTSTSYLLLASLDVARKRL ATEGRQLAEETLKLANQTRDRLNQIEGIYCVGSEILGSKAAYSYDPTKLIISVKSLGL TGHDVEKWLRESFNIEVELSDLYNILCIFTPGDSQNDADRLVEALTEIAQQMSEQDVT HQQTEVLLPEIPLLAMTPRDAFYANTEVIPLKEASGRIIAEFVMVYPPGIPIFIPGEI ITEENISYIFKNLDAGLPVQGPEDSTLHMIRVIKEQKAIQ*" gene complement(1534279..1535751) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" downshifts complement(1534297) /Source="Nicolas_upshifts" /id="D824" /incds=0 /nref=62 /ntot=198 /MaxReadThrough="3.88498" /MaxDrop="6.76978" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin="-17" /isTUend="TRUE" S_feature complement(1535752..1535847) /Source="Nicolas_S_feature" /locus_tag="new_1535752_1535847_c" /HighExp="Paraq, G180, LBGexp, Oxctl, G150, G135, C30, H2O2, BMM, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S535" promotor_-10 complement(1535830..1535849) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1535847) /Source="Nicolas_upshifts" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" promotor_-35 1535854..1535857 /Source="Nicolas_upshift_promotors" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1535864..1535871) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1535872..1535891 /Source="Nicolas_upshift_promotors" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1535876 /Source="Nicolas_upshifts" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" CDS 1535936..1536202 /gene="yktA" /locus_tag="BSU_14640" /old_locus_tag="BSU14640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19429628, 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389347.1" /db_xref="EnsemblGenomes-Gn:BSU14640" /db_xref="EnsemblGenomes-Tr:CAB13337" /db_xref="InterPro:IPR007920" /db_xref="InterPro:IPR023324" /db_xref="SubtiList:BG11816" /db_xref="UniProtKB/Swiss-Prot:Q45497" /translation="MEYQYPMNEDWTTEEAVDVIAFFQQVELAYEKGADREELLKAYR RFKEIVPGKAEEKKLCGEFEEQSTYSPYRTVKQARESDHAKIKM*" gene 1535936..1536202 /gene="yktA" /locus_tag="BSU_14640" /old_locus_tag="BSU14640" downshifts 1536184 /Source="Nicolas_upshifts" /id="D825" /incds=0 /nref=105 /ntot=250 /MaxReadThrough="2.62284" /MaxDrop="5.09814" /score="40.0811023" /energy="-16.1" /TU="NA" /idTUdmin="U1214" /TUdmin=0 /isTUend="TRUE" CDS complement(1536235..1536873) /gene="yktB" /locus_tag="BSU_14650" /old_locus_tag="BSU14650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25643072" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389348.1" /db_xref="EnsemblGenomes-Gn:BSU14650" /db_xref="EnsemblGenomes-Tr:CAB13338" /db_xref="InterPro:IPR009403" /db_xref="PDB:2A8E" /db_xref="SubtiList:BG11817" /db_xref="UniProtKB/Swiss-Prot:Q45498" /translation="MTQMRFTEEDFNTFTIEGLDARMEVLKETVRPKLTALGEHFAPT LSALTGDEMFPHVAKHARRSVNPPADSWVAFANSKRGYKKLPHFQIGLWESHVFVWFA IIYESPIKEEYGKLLEVNQETITKNIPDSFVWSADHTKPGVHKQSEMDKEQLKTLFER LQTVKKAELLCGIQLQKEEVLNMNNQEFLQRIDDAFKQLAFLYRLTQKVTQA*" gene complement(1536235..1536873) /gene="yktB" /locus_tag="BSU_14650" /old_locus_tag="BSU14650" downshifts complement(1536260) /Source="Nicolas_upshifts" /id="D826" /incds=0 /nref=184 /ntot=257 /MaxReadThrough="2.62959" /MaxDrop="6.54203" /score="26.7765804" /energy="-14.5" /TU="U1217" /idTUdmin="U1217" /TUdmin="-22" /isTUend="TRUE" promotor_-10 complement(1536894..1536913) /Source="Nicolas_upshift_promotors" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1536918) /Source="Nicolas_upshifts" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" promotor_-35 complement(1536928..1536932) /Source="Nicolas_upshift_promotors" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1536943..1536949 /Source="Nicolas_upshift_promotors" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1536964..1536982 /Source="Nicolas_upshift_promotors" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1536965 /Source="Nicolas_upshifts" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" promotor_-35 1537003..1537012 /Source="Nicolas_upshift_promotors" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1537025..1537044 /Source="Nicolas_upshift_promotors" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1537029..1537112 /Source="Nicolas_S_feature" /locus_tag="new_1537029_1537112" /HighExp="Etha, S7, M9-stat, S6, S8, BT, Gly, Salt, B60, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB" /TUshortPSig="0.987, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S536" upshifts 1537029 /Source="Nicolas_upshifts" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" CDS 1537113..1537301 /gene="ykzI" /locus_tag="BSU_14660" /old_locus_tag="BSU14660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved general stress protein" /protein_id="NP_389349.1" /db_xref="EnsemblGenomes-Gn:BSU14660" /db_xref="EnsemblGenomes-Tr:CAB13339" /db_xref="SubtiList:BG13337" /db_xref="UniProtKB/Swiss-Prot:O31719" /translation="MRQVVKEGFKEEKNNRVAVWRLEVDYELATLYEAMQKENEEQIE QSKNKLERLRKEWIRLNG*" gene 1537113..1537301 /gene="ykzI" /locus_tag="BSU_14660" /old_locus_tag="BSU14660" downshifts complement(1537118) /Source="Nicolas_upshifts" /id="D827" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="1.50398" /MaxDrop="3.97385" /score="26.7765804" /energy="-14.5" /TU="NA" /idTUdmin="U1220" /TUdmin=0 /isTUend="TRUE" downshifts 1537294 /Source="Nicolas_upshifts" /id="D828" /incds=0 /nref=13 /ntot=45 /MaxReadThrough="7.33866" /MaxDrop="6.12123" /score="-8.73613673" /energy="-8.1" /TU="U1218,U1219" /idTUdmin="U1219" /TUdmin="-628" /isTUend="FALSE" upshifts complement(1537316) /Source="Nicolas_upshifts" /id="U1220" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.616383616383616" /psig="0.105894105894106" /xcortree=118 /SigmaFactorBS="agcaaggaaaatgaaaaatatcccttctcacgtaaaaacgaa ccattcaTGCGgttcgttttcactatcgcttttttacccgttaagacgaatccattct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(1537324..1537327) /Source="Nicolas_upshift_promotors" /id="U1220" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.616383616383616" /psig="0.105894105894106" /xcortree=118 /SigmaFactorBS="agcaaggaaaatgaaaaatatcccttctcacgtaaaaacgaa ccattcaTGCGgttcgttttcactatcgcttttttacccgttaagacgaatccattct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1537371..1537374 /Source="Nicolas_upshift_promotors" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1537391..1537410 /Source="Nicolas_upshift_promotors" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1537394 /Source="Nicolas_upshifts" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" CDS 1537441..1538238 /gene="suhB" /locus_tag="BSU_14670" /old_locus_tag="BSU14670" /EC_number="3.1.3.-" /EC_number="3.1.3.25" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11914086, 16682444, 22333191, 27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914086, 16682444, 22333191, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inositol monophosphatase / 5' nucleotidase (purine nucleoside monophosphate)" /protein_id="NP_389350.1" /db_xref="EnsemblGenomes-Gn:BSU14670" /db_xref="EnsemblGenomes-Tr:CAB13340" /db_xref="GOA:Q45499" /db_xref="InterPro:IPR000760" /db_xref="InterPro:IPR020550" /db_xref="InterPro:IPR020583" /db_xref="InterPro:IPR033942" /db_xref="SubtiList:BG11818" /db_xref="UniProtKB/Swiss-Prot:Q45499" /translation="MTNWTEIDEIAKKWIREAGARITQSMHESLTIETKSNPNDLVTN IDKETEKFFIDRIQETFPGHRILGEEGQGDKIHSLEGVVWIIDPIDGTMNFVHQQRNF AISIGIFENGEGKIGLIYDVVHDELYHAFSGRGAYMNETKLAPLKETVIEEAILAINA TWVTENRRIDQSVLAPLVKRVRGTRSYGSAALELANVAAGRIDAYITMRLAPWDYAAG CVLLNEVGGTYTTIEGEPFTFLENHSVLAGNPSIHKTIFEEYLHARK*" gene 1537441..1538238 /gene="suhB" /locus_tag="BSU_14670" /old_locus_tag="BSU14670" CDS 1538264..1538692 /gene="ykzC" /locus_tag="BSU_14680" /old_locus_tag="BSU14680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544224; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_389351.1" /db_xref="EnsemblGenomes-Gn:BSU14680" /db_xref="EnsemblGenomes-Tr:CAB13341" /db_xref="GOA:O31720" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13331" /db_xref="UniProtKB/Swiss-Prot:O31720" /translation="MLEKLAEAHPVWKEEEFGDKDAEDYIISYSMYNGSWLVWEKDGM PVAVSYHLEWSPSNGKPWLGTVLIDPAEEKKGHAKMIIEQISKLLRAKHKAMFAGVPI ERREWILFLSQCGFEQLKTEKDEKGKSFMILVKPLAEAAV*" gene 1538264..1538692 /gene="ykzC" /locus_tag="BSU_14680" /old_locus_tag="BSU14680" downshifts 1538649 /Source="Nicolas_upshifts" /id="D829" /incds=0 /nref=80 /ntot=232 /MaxReadThrough="4.50069" /MaxDrop="4.3098" /score="-9.99315734" /energy="-11.8" /TU="U1218,U1221" /idTUdmin="U1218" /TUdmin="-153" /isTUend="FALSE" S_feature 1538693..1539646 /Source="Nicolas_S_feature" /locus_tag="new_1538693_1539646" /HighExp="H2O2, dia15, Diami, Paraq, G180, G135, G150, dia5, Heat, LBGexp" /AntisenseName="yktD" /AntisenseCor="-1.5120906229522399E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="0.117724" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S537" downshifts complement(1538768) /Source="Nicolas_upshifts" /id="D830" /incds=0 /nref=4 /ntot=85 /MaxReadThrough="0.88821" /MaxDrop="3.44773" /score="19.9363134" /energy="-12.8" /TU="NA" /idTUdmin="U1222" /TUdmin=0 /isTUend="TRUE" CDS complement(1538770..1539684) /gene="yktD" /locus_tag="BSU_14690" /old_locus_tag="BSU14690" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17928718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AdoMet-dependent methyltransferase" /protein_id="NP_389352.1" /db_xref="EnsemblGenomes-Gn:BSU14690" /db_xref="EnsemblGenomes-Tr:CAB13342" /db_xref="GOA:Q45500" /db_xref="InterPro:IPR007213" /db_xref="InterPro:IPR011610" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11819" /db_xref="UniProtKB/Swiss-Prot:Q45500" /translation="MRKNESSLTSLISAFARAYHSRYDTPLIFDDFIAKDLINEKEFI DISKNMIQEISFFNKEIAERLQNDPEKILKWVAQIQLSPTPLARASYCEKVLHNELIL GAKQYVILGAGLDTFCFRHPELENSLQVFEVDHPATQQLKKNKLKDANLTIPGHLHFV PMDFTKTFSYDPLLDEGFKNTKTFFSLLGVSYYVTREENASLISNLFSHVPPGSSIVF DYADETLFTAKGTSNRVEHMVKMAAASGEPMKSCFTYQEIEHLLESSGLLIYEHLSPD DINDLFFSNRKDNLSAFETIHYIHAVKK*" gene complement(1538770..1539684) /gene="yktD" /locus_tag="BSU_14690" /old_locus_tag="BSU14690" promotor_-10 complement(1539750..1539769) /Source="Nicolas_upshift_promotors" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1539758) /Source="Nicolas_upshifts" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" promotor_-35 complement(1539784..1539791) /Source="Nicolas_upshift_promotors" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1540036..1541601) /gene="nprE" /locus_tag="BSU_14700" /old_locus_tag="BSU14700" /EC_number="3.4.24.28" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2128597, 6090407, 8436952, 15205417, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2128597, 6090407, 8436952, 15205417, 26728191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular neutral metalloprotease" /protein_id="NP_389353.1" /db_xref="EnsemblGenomes-Gn:BSU14700" /db_xref="EnsemblGenomes-Tr:CAB13343" /db_xref="GOA:P68736" /db_xref="InterPro:IPR001570" /db_xref="InterPro:IPR011096" /db_xref="InterPro:IPR013856" /db_xref="InterPro:IPR023612" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG10448" /db_xref="UniProtKB/Swiss-Prot:P68736" /translation="MGLGKKLSVAVAASFMSLSISLPGVQAAEGHQLKENQTNFLSKN AIAQSELSAPNDKAVKQFLKKNSNIFKGDPSKRLKLVESTTDALGYKHFRYAPVVNGV PIKDSQVIVHVDKSDNVYAVNGELHNQSAAKTDNSQKVSSEKALALAFKAIGKSPDAV SNGAAKNSNKAELKAIETKDGSYRLAYDVTIRYVEPEPANWEVLVDAETGSILKQQNK VEHAAATGSGTTLKGATVPLNISYEGGKYVLRDLSKPTGTQIITYDLQNRQSRLPGTL VSSTTKTFTSSSQRAAVDAHYNLGKVYDYFYSNFKRNSYDNKGSKIVSSVHYGTQYNN AAWTGDQMIYGDGDGSFFSPLSGSLDVTAHEMTHGVTQETANLIYENQPGALNESFSD VFGYFNDTEDWDIGEDITVSQPALRSLSNPTKYNQPDNYANYRNLPNTDEGDYGGVHT NSGIPNKAAYNTITKLGVSKSQQIYYRALTTYLTPSSTFKDAKAALIQSARDLYGSTD AAKVEAAWNAVGL*" gene complement(1540036..1541601) /gene="nprE" /locus_tag="BSU_14700" /old_locus_tag="BSU14700" promotor_-10 complement(1541636..1541655) /Source="Nicolas_upshift_promotors" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1541647) /Source="Nicolas_upshifts" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" promotor_-35 complement(1541669..1541676) /Source="Nicolas_upshift_promotors" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1541886..1543826 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16501307" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389354.1" /db_xref="EnsemblGenomes-Gn:BSU14710" /db_xref="EnsemblGenomes-Tr:CAB13344" /db_xref="GOA:O07625" /db_xref="SubtiList:BG13338" /db_xref="UniProtKB/Swiss-Prot:O07625" /translation="MLFVLELFSHYVLHFERYFILSRQSTLLIQWSIVVLAGLYLLVH HPKINRQRTMFLAGVILRIVLLAGVSVELIHQVQSTNFTSAYLREDGKELLPLLHFLL YGYVLLTAFHYMLMPRDHGGKGKFYTFDLAVVSLPIVQMIFSFFSYWKEYPDGMEPIA FVFLFFIITLPIALNVVFFKLYWRTDKILLGLFYTLIIGLLVLLLAPYPNQISKDYGA VMPYTIYLAMAGFLMSYHLFQKSGKVYVRVNKWVTMAVMVFFVLLLNPIYNIGTAAFA VSKPANVHDSFNFVGEHISSEKAEQILKSFFPTDETLYLHDTNMDVHYFYSFESKGYK AEVDEVSQLIRNYEYLQKAHGKKLTNQEYKRKSIAFLERHGRVLHKDHIETKVSQEDG QTVVRIYLKNQLHKKDHADDGAVFYWEKETLMGFSEDPSIYQLDSLLHVHITEQDIHD KVEQMFTALNISKQPYQITDIESDSLLGSMVRVETKVGIVLEFEGESGCLHSLSLPMK KNISMANSRLQHQILSIFDARGSEKKKKSSQGDMVMYTDSSKTYEFVEAQGQLNVYVY SDTPDQSFPYTYRNGTLAYEKVASLYQDVIYKKRMRPIIVQRGDERHYAWLIIIQPFG SNRHDAYVVDGETQEVKSLYES*" gene 1541886..1543826 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" CDS 1543816..1544085 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 16501307" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389355.1" /db_xref="EnsemblGenomes-Gn:BSU14720" /db_xref="EnsemblGenomes-Tr:CAB13345" /db_xref="GOA:O07626" /db_xref="SubtiList:BG13339" /db_xref="UniProtKB/Swiss-Prot:O07626" /translation="MNHKEKESVFVDLYDLYKEGELEDESMEWMKQHESLFQKNAEDL KSKTCLKRSPGAEEESQIRYMKVYLSSMYICFILLAIWMTVWFYF*" gene 1543816..1544085 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" promotor_-35 1544051..1544055 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1544069..1544088 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1544082 /Source="Nicolas_upshifts" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" CDS 1544085..1544606 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF-type sigma factor" /protein_id="NP_389356.1" /db_xref="EnsemblGenomes-Gn:BSU14730" /db_xref="EnsemblGenomes-Tr:CAB13346" /db_xref="GOA:O07627" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13340" /db_xref="UniProtKB/Swiss-Prot:O07627" /translation="MKHRDSIEDLYRQYYQEILNYLFRRTHHLETAKDLAQDTFVKAL NGLASFRGHSSIRTWLYTIAHHTFINWYRRDVKYQFTEISKNEGLTQTTYDQPEQYLS RTVKSETLRQELLKLKDQHQSVLILREFQELSYEEIAEILGWSLSKVNTTLHRARLEL KKNMTKSREEERI*" gene 1544085..1544606 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" CDS 1544603..1544896 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-SigP(YlaC) sigma factor" /protein_id="NP_389357.1" /db_xref="EnsemblGenomes-Gn:BSU14740" /db_xref="EnsemblGenomes-Tr:CAB13347" /db_xref="GOA:O07628" /db_xref="InterPro:IPR027383" /db_xref="SubtiList:BG13341" /db_xref="UniProtKB/Swiss-Prot:O07628" /translation="MTCFLVRDLLPLYLEGDCKRETEHVIEEHLKMCSSCRDMYDTMA EPFELESEQAVEEAYLPEEELRFKQRYYGLLIMKAACWFGAAVAMMLIIKLLI*" gene 1544603..1544896 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" CDS complement(1544936..1545547) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389358.1" /db_xref="EnsemblGenomes-Gn:BSU14750" /db_xref="EnsemblGenomes-Tr:CAB13348" /db_xref="SubtiList:BG13342" /db_xref="UniProtKB/Swiss-Prot:O07629" /translation="MKKTFVKKAMLTTAAMTSAALLTFGPDAASAKTPVDNTAVQLQH QASTNEDLNTFIDILNQCIYEQDGVYYFDSEKAVELGMTKEEAQVIATLWESTSEFFS IVSQCVYLEDGNYKFDTEKAVELGFTEKEALALEQFFSAVSLKIHILQAAIVLQDDVY SYDKDAALQAGATPLQADVYEKLFSALSQEQLAAIYDMIHPQA*" gene complement(1544936..1545547) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" downshifts complement(1544950) /Source="Nicolas_upshifts" /id="D831" /incds=0 /nref=44 /ntot=184 /MaxReadThrough="1.37453" /MaxDrop="4.23106" /score="20.8244305" /energy="-11.7" /TU="NA" /idTUdmin="U1225" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1545579..1545598) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1545588) /Source="Nicolas_upshifts" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" promotor_-35 complement(1545613..1545616) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1545803) /Source="Nicolas_upshifts" /id="D832" /incds=0 /nref=18 /ntot=138 /MaxReadThrough="2.72081" /MaxDrop="5.25382" /score="5.78870736" /energy="-8.3" /TU="NA" /idTUdmin="U1226" /TUdmin="-17" /isTUend="TRUE" CDS complement(1545820..1546008) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389359.1" /db_xref="EnsemblGenomes-Gn:BSU14760" /db_xref="EnsemblGenomes-Tr:CAB13349" /db_xref="GOA:O07630" /db_xref="InterPro:IPR035211" /db_xref="SubtiList:BG13343" /db_xref="UniProtKB/Swiss-Prot:O07630" /translation="MKKMNWLLLLFAFAAVFSIMLIGVFIAEKSPAGIIASIVLVCAV MGGGFTLKKKMREQGLLD*" gene complement(1545820..1546008) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" downshifts complement(1545874) /Source="Nicolas_upshifts" /id="D833" /incds=0 /nref=9 /ntot=204 /MaxReadThrough="4.38484" /MaxDrop="3.2214" /score="5.78870736" /energy="-8.3" /TU="U1226" /idTUdmin="U1226" /TUdmin="-88" /isTUend="FALSE" promotor_-10 complement(1546030..1546049) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1546047) /Source="Nicolas_upshifts" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" promotor_-35 complement(1546062..1546069) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1546075..1546094 /Source="Nicolas_upshift_promotors" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1546082 /Source="Nicolas_upshifts" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" CDS 1546121..1547959 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11683274, 12399512, 9642082, 25135187, 26283392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-associated GTPase" /protein_id="NP_389360.1" /db_xref="EnsemblGenomes-Gn:BSU14770" /db_xref="EnsemblGenomes-Tr:CAB13350" /db_xref="GOA:O07631" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006298" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035651" /db_xref="SubtiList:BG13344" /db_xref="UniProtKB/Swiss-Prot:O07631" /translation="MKLRNDLRNIAIIAHVDHGKTTLVDQLLHQAGTFRANEQVAERA MDSNDLERERGITILAKNTAINYKDTRINILDTPGHADFGGEVERIMKMVDGVVLVVD AYEGCMPQTRFVLKKALEQNLNPVVVVNKIDRDFARPEEVIDEVLDLFIELDANEEQL EFPVVYASAINGTASLDPKQQDENMEALYETIIKHVPAPVDNAEEPLQFQVALLDYND YVGRIGIGRVFRGTMKVGQQVSLMKLDGTAKSFRVTKIFGFQGLKRVEIEEAKAGDLV AVSGMEDINVGETVCPVDHQDPLPVLRIDEPTLQMTFVVNNSPFAGREGKYVTARKIE ERLQSQLQTDVSLRVEPTASPDAWVVSGRGELHLSILIENMRREGYELQVSKPEVIIK EIDGVRCEPVERVQIDVPEEHTGSVMESMGARKGEMVDMINNGNGQVRLIFTVPSRGL IGYSTEFLSLTRGFGILNHTFDSYQPMQAGQVGGRRQGVLVSMENGKATSYGIQGIED RGVIFVEPGTEVYEGMIVGEHNRDNDLVVNVSKMKQQTNVRSATKDQTTTIKKARIMS LEESLEYLNEDEYCEVTPESIRLRKKILNKNEREKAAKKKKTAGLS*" gene 1546121..1547959 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" CDS 1548016..1548333 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unkown function" /protein_id="NP_389361.1" /db_xref="EnsemblGenomes-Gn:BSU14780" /db_xref="EnsemblGenomes-Tr:CAB13351" /db_xref="GOA:O07632" /db_xref="InterPro:IPR025620" /db_xref="SubtiList:BG13345" /db_xref="UniProtKB/Swiss-Prot:O07632" /translation="MNDVSERLSFFAALYQVDRQPAAGMWLLYGTIFVLAVIVFKLGF AKRLPVLKSAVVYVFLALGCTVLTFLGVFLPVAEGLVVAALILIIYKIRLYQSKKGQS AKS*" gene 1548016..1548333 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" downshifts 1548307 /Source="Nicolas_upshifts" /id="D834" /incds=0 /nref=241 /ntot=297 /MaxReadThrough="2.76511" /MaxDrop="7.50514" /score="29.8701447" /energy="-12.5" /TU="NA" /idTUdmin="U1227" /TUdmin="-21" /isTUend="TRUE" downshifts complement(1548382) /Source="Nicolas_upshifts" /id="D835" /incds=0 /nref=240 /ntot=265 /MaxReadThrough="0.672690000000001" /MaxDrop="7.03405" /score="10.4340016" /energy="-12.5" /TU="NA" /idTUdmin="U1228" /TUdmin=0 /isTUend="TRUE" CDS complement(1548389..1548598) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389362.1" /db_xref="EnsemblGenomes-Gn:BSU14790" /db_xref="EnsemblGenomes-Tr:CAB13352" /db_xref="InterPro:IPR019241" /db_xref="SubtiList:BG13346" /db_xref="UniProtKB/Swiss-Prot:O07633" /translation="MMRVKCSICDKIETIDDDTLIAKRLRNRPIHTYMCQECHDRIAK KTEERLKTGKFTFHPGQQKKEKVKK*" gene complement(1548389..1548598) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" misc_feature complement(1548612..1548631) /Source="Nicolas_upshift_promotors" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1548627) /Source="Nicolas_upshifts" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" CDS complement(1548681..1549310) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_389363.1" /db_xref="EnsemblGenomes-Gn:BSU14800" /db_xref="EnsemblGenomes-Tr:CAB13353" /db_xref="GOA:O07634" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13347" /db_xref="UniProtKB/Swiss-Prot:O07634" /translation="MRILFIIIQLTLILSACAYQQGKQGQNVEKESTRQQETKPIHVK DTTQETKDNGTRTDIAKHLVSVAEKNPDVKDATAVVLGGYAVVGIDVDDTLDRSKVET IKYSVAQALKNDRYGANAVVIADPDTVSRLREMSREISEGHPVTGILDELAAIVGRVL PEVPNDVIDNEDEPQTKQQNDQLNRKQQQEMEKEQNDQSDHHMKKNNND*" gene complement(1548681..1549310) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" downshifts complement(1548712) /Source="Nicolas_upshifts" /id="D836" /incds=0 /nref=57 /ntot=112 /MaxReadThrough="1.90936" /MaxDrop="5.8475" /score="3.85709048" /energy="-7.2" /TU="NA" /idTUdmin="U1229" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1549212..1549230) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1549218) /Source="Nicolas_upshifts" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1549242..1549250) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1549345..1549356) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1549350) /Source="Nicolas_upshifts" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" promotor_-35 1549362..1549367 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-35" promotor_-35 complement(1549371..1549377) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1549383..1549401 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-10" upshifts 1549383 /Source="Nicolas_upshifts" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" S_feature 1549384..1549464 /Source="Nicolas_S_feature" /locus_tag="new_1549384_1549464" /HighExp="S3, S5, S4, S8, S6, S7, LoTm, T5.0H, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S538" CDS 1549465..1550793 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12762842, 17114254; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phosphate starvation inducible protein" /protein_id="NP_389364.1" /db_xref="EnsemblGenomes-Gn:BSU14810" /db_xref="EnsemblGenomes-Tr:CAB13354" /db_xref="GOA:O07635" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG13348" /db_xref="UniProtKB/Swiss-Prot:O07635" /translation="MSKIYVLDTNVLLQDPNAIFSFEENEVVIPAVVLEEVDSKKRYM DEVGRNARHVSKLIDALRQKGRLHEHVPLDTGGTLRIELNHRSFHQLQEIFIEKTNDN RILAVAKNLSLEEETKENGRPVILVSKDVLVRVKADAIGLLAEDFLNDRVVDNDEMYS GYKDLYISQQLFSSFYGKNQISVNDVKQHAFYPNQFALMKDELGGSSSAVGIADKTGT VLKRLVFDDEHIWGIRPKNVQQTMALELLLREDIPLVTLIGKAGTGKTLLALAAGLLQ TEDLGIYKKLVVARPIVPVGKDIGYLPGEKEEKLKPWMQPIFDNLEFLFNAKKPGELD AILAGIGSIQVEALTYIRGRSIPDQFIIIDEAQNLTRHEVKTLLTRVGEGSKIVLMGD PEQIDHPYLDSLNNGLAYVVERFKGQPISGSVKLLKGERSGLAQLAADLL*" gene 1549465..1550793 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" S_feature complement(1550649..1550796) /Source="Nicolas_S_feature" /locus_tag="new_1550649_1550796_c" /HighExp="M40t90, M0t90, dia15, Lbtran, dia5, Etha, Mt0, Gly, LBGtran, LPhT" /AntisenseName="ylaK" /AntisenseCor="-0.66426410013570203" /AntisenseRegPval="-34.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S539" downshifts complement(1550692) /Source="Nicolas_upshifts" /id="D837" /incds=1 /nref=6 /ntot=67 /MaxReadThrough="3.81309" /MaxDrop="3.44499" /score="3.85709048" /energy="-7.2" /TU="U1232" /idTUdmin="U1232" /TUdmin="-198" /isTUend="FALSE" S_feature 1550794..1551384 /Source="Nicolas_S_feature" /locus_tag="new_1550794_1551384" /HighExp="S3, S4, S6, S5, S8, S7, BT, B36, LoTm, T5.0H" /AntisenseName="ylaL" /AntisenseCor="-0.79954210237955903" /AntisenseRegPval="-60.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S540" CDS complement(1550797..1551282) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389365.1" /db_xref="EnsemblGenomes-Gn:BSU14820" /db_xref="EnsemblGenomes-Tr:CAB13355" /db_xref="GOA:O07636" /db_xref="InterPro:IPR020229" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13349" /db_xref="UniProtKB/Swiss-Prot:O07636" /translation="MSVIQVKGNVTYPITIDPSVWIFDDRKFSFDRKGDSQDTYLQSA GDESDLDPERVIREGRIAPPTLKTEKQYEKQKLMNGSFAMRLGTVLKNAEPNSSATQC VFVTSSGKAAVSLETALNSIVHFSEAGKPIQEGGPVHIYFEDPVHHKQPITDVKEIEI I*" gene complement(1550797..1551282) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" promotor_-10 complement(1551294..1551313) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1551322) /Source="Nicolas_upshifts" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" promotor_-35 complement(1551328..1551335) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1551385..1552314 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:18459799" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18459799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine amidohydrolase; glutaminase" /protein_id="NP_389366.1" /db_xref="EnsemblGenomes-Gn:BSU14830" /db_xref="EnsemblGenomes-Tr:CAB13356" /db_xref="GOA:O07637" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="SubtiList:BG13350" /db_xref="UniProtKB/Swiss-Prot:O07637" /translation="MVCQHNDELEALVKKAKKVTDKGEVASYIPALAKADKHDLSVAI YYSNNVCLSAGDVEKTFTLQSISKVLSLALVLMEYGKDKVFSYVGQEPTGDPFNSIIK LETVNPSKPLNPMINAGALVVTSLIRGRTVKERLDYLLSFIRRLTNNQEITYCREVAE SEYSTSMINRAMCYYMKQYGIFEDDVEAVMDLYTKQCAIEMNSLDLAKIGSVFALNGR HPETGEQVISKDVARICKTFMVTCGMYNASGEFAIKVGIPAKSGVSGGIMGISPYDFG IGIFGPALDEKGNSIAGVKLLEIMSEMYRLSIF*" gene 1551385..1552314 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" misc_feature 1551899..1551918 /Source="Nicolas_upshift_promotors" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1551908 /Source="Nicolas_upshifts" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" promotor_-35 1552338..1552341 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1552356..1552375 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1552364 /Source="Nicolas_upshifts" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" CDS 1552412..1552693 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12682299, 16880555, 17005971,17469204" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389367.1" /db_xref="EnsemblGenomes-Gn:BSU14840" /db_xref="EnsemblGenomes-Tr:CAB13357" /db_xref="InterPro:IPR009983" /db_xref="InterPro:IPR036270" /db_xref="SubtiList:BG13351" /db_xref="UniProtKB/Swiss-Prot:O07638" /translation="MASEMIVDHRQKAFELLKVDAEKILKLIRVQMDNLTMPQCPLYE EVLDTQMFGLSREIDFAVRLGLVDEKDGKDLLYTLERELSALHDAFTAK*" gene 1552412..1552693 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" downshifts 1552682 /Source="Nicolas_upshifts" /id="D838" /incds=0 /nref=72 /ntot=227 /MaxReadThrough="5.3857" /MaxDrop="6.58793" /score="2.26145837" /energy="-6.9" /TU="U1234" /idTUdmin="U1231" /TUdmin=328 /isTUend="FALSE" promotor_-35 1552756..1552759 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1552772..1552898 /Source="Nicolas_S_feature" /locus_tag="new_1552772_1552898" /HighExp="S1, T5.0H, T4.0H, HiOs, T3.30H, T3.0H, Etha, Heat, T2.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="0.619, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S541" upshifts 1552772 /Source="Nicolas_upshifts" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" promotor_-10 1552777..1552783 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1552899..1554110 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9622350, 12626683, 15849754, 16850406, 21386816, 27895631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 12626683, 15849754, 16850406, 21386816, 27895631; Product type t : transporter" /codon_start=1 /transl_table=11 /product="cell-division protein; transporter of lipid-linked cell wall precursors" /protein_id="NP_389368.1" /db_xref="EnsemblGenomes-Gn:BSU14850" /db_xref="EnsemblGenomes-Tr:CAB13358" /db_xref="GOA:O07639" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG13352" /db_xref="UniProtKB/Swiss-Prot:O07639" /translation="MLKKMLKSYDYSLIFAIVLLCGFGLVMVYSSSMITAVSRYGVSS NFFFMRQLFALIAGGALFILMALFPYKALAHQKFQKGILLVSVLALISLFVFGHVAGN AQSWFKIGGMSIQPGEFVKLVVILYLAAVYAKKQSYIDHLLTGVAPPVVMTLIICGLI AMQPDFGTAMIIGLIATCMILCSGFSGKTLVRLVILGGIVFILVSPIIYLNQDKILTE GRLARFESLEDPFKYANSSGLQVINSYYAISSGGIFGLGLGESIQKYGYLPESHTDFI MAVIAEELGIFGVLFVIFLLGFVVIKGFYIARKCEDPFGSLLAIGISSMIAIQSFINL GGVSGLIPITGVTLPFISYGGSSLVLLLGSMGILANISMFVKYSENKKKKEPLAPKGM KKKQLKKTVYL*" gene 1552899..1554110 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" promotor_-35 1554120..1554124 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1554139..1554158 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1554158 /Source="Nicolas_upshifts" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" CDS 1554185..1557631 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" /EC_number="6.4.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6425269, 15134465, 20081037, 20097852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate carboxylase" /protein_id="NP_389369.1" /db_xref="EnsemblGenomes-Gn:BSU14860" /db_xref="EnsemblGenomes-Tr:CAB13359" /db_xref="GOA:Q9KWU4" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR003379" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR005930" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG12660" /db_xref="UniProtKB/Swiss-Prot:Q9KWU4" /translation="MSQQSIQKVLVANRGEIAIRIFRACTELNIRTVAVYSKEDSGSY HRYKADEAYLVGEGKKPIDAYLDIEGIIDIAKRNKVDAIHPGYGFLSENIHFARRCEE EGIVFIGPKSEHLDMFGDKVKAREQAEKAGIPVIPGSDGPAETLEAVEQFGQANGYPI IIKASLGGGGRGMRIVRSESEVKEAYERAKSEAKAAFGNDEVYVEKLIENPKHIEVQV IGDKQGNVVHLFERDCSVQRRHQKVIEVAPSVSLSPELRDQICEAAVALAKNVNYINA GTVEFLVANNEFYFIEVNPRVQVEHTITEMITGVDIVQTQILVAQGHSLHSKKVNIPE QKDIFTIGYAIQSRVTTEDPQNDFMPDTGKIMAYRSGGGFGVRLDTGNSFQGAVITPY YDSLLVKLSTWALTFEQAAAKMVRNLQEFRIRGIKTNIPFLENVAKHEKFLTGQYDTS FIDTTPELFNFPKQKDRGTKMLTYIGNVTVNGFPGIGKKEKPAFDKPLGVKVDVDQQP ARGTKQILDEKGAEGLANWVKEQKSVLLTDTTFRDAHQSLLATRIRSHDLKKIANPTA ALWPELFSMEMWGGATFDVAYRFLKEDPWKRLEDLRKEVPNTLFQMLLRSSNAVGYTN YPDNVIKEFVKQSAQSGIDVFRIFDSLNWVKGMTLAIDAVRDTGKVAEAAICYTGDIL DKNRTKYDLAYYTSMAKELEAAGAHILGIKDMAGLLKPQAAYELVSALKETIDIPVHL HTHDTSGNGIYMYAKAVEAGVDIIDVAVSSMAGLTSQPSASGFYHAMEGNDRRPEMNV QGVELLSQYWESVRKYYSEFESGMKSPHTEIYEHEMPGGQYSNLQQQAKGVGLGDRWN EVKEMYRRVNDMFGDIVKVTPSSKVVGDMALYMVQNNLTEKDVYEKGESLDFPDSVVE LFKGNIGQPHGGFPEKLQKLILKGQEPITVRPGELLEPVSFEAIKQEFKEQHNLEISD QDAVAYALYPKVFTDYVKTTESYGDISVLDTPTFFYGMTLGEEIEVEIERGKTLIVKL ISIGEPQPDATRVVYFELNGQPREVVIKDESIKSSVQERLKADRTNPSHIAASMPGTV IKVLAEAGTKVNKGDHLMINEAMKMETTVQAPFSGTIKQVHVKNGEPIQTGDLLLEIE KA*" gene 1554185..1557631 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" promotor_-10 complement(1557197..1557215) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1557217) /Source="Nicolas_upshifts" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1557231..1557236) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1557611 /Source="Nicolas_upshifts" /id="D839" /incds=0 /nref=20 /ntot=213 /MaxReadThrough="5.5667" /MaxDrop="6.03063" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin="-1" /isTUend="TRUE" downshifts 1557656 /Source="Nicolas_upshifts" /id="D840" /incds=0 /nref=2 /ntot=51 /MaxReadThrough="4.21552" /MaxDrop="4.9051" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=44 /isTUend="FALSE" downshifts complement(1557688) /Source="Nicolas_upshifts" /id="D841" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="2.24992" /MaxDrop="3.11732" /score="10.1921506" /energy="-11.8" /TU="NA" /idTUdmin="U1238" /TUdmin=330 /isTUend="FALSE" downshifts 1557700 /Source="Nicolas_upshifts" /id="D842" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="3.6246" /MaxDrop="4.10361" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=88 /isTUend="FALSE" CDS complement(1558034..1558954) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" /EC_number="1.3.-.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12206660, 15491161, 15849754, 16321940, 16850406, 26592143" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12206660, 15491161, 15849754, 16321940, 16850406, 26592143; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heme-A synthase" /protein_id="NP_389370.1" /db_xref="EnsemblGenomes-Gn:BSU14870" /db_xref="EnsemblGenomes-Tr:CAB13360" /db_xref="GOA:P12946" /db_xref="InterPro:IPR003780" /db_xref="InterPro:IPR023755" /db_xref="SubtiList:BG10213" /db_xref="UniProtKB/Swiss-Prot:P12946" /translation="MNKALKALGVLTTFVMLIVLIGGALVTKTGSGQGCGRQWPLCHG RFFPELNPASIIEWSHRFASGISIILVLSLAFWSWRKITPIFRETTFLAIMSIIFLFL QALLGALAVVFGSNALIMALHFGISLISFASVLILTLLIFEADKSVRTLVKPLQIGKK MQFHMIGILIYSYIVVYTGAYVRHTESSLACPNVPLCSPLNNGLPTQFHEWVQMGHRA AALLLFVWIIVAAVHAITSYKDQKQIFWGWISCLIFITLQALSGIMIVYSELALGFAL AHSFFIACLFGVLCYFLLLIARFRYESRQS*" gene complement(1558034..1558954) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" downshifts complement(1558040) /Source="Nicolas_upshifts" /id="D843" /incds=0 /nref=126 /ntot=238 /MaxReadThrough="2.72676" /MaxDrop="5.67271" /score="28.8671863" /energy="-15.3" /TU="U1238" /idTUdmin="U1238" /TUdmin="-22" /isTUend="TRUE" promotor_-10 complement(1558994..1559013) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1559009) /Source="Nicolas_upshifts" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" promotor_-35 complement(1559027..1559034) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1559089..1559096 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1559110..1559129 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1559111..1559216 /Source="Nicolas_S_feature" /locus_tag="new_1559111_1559216" /HighExp="LBGstat, M0t90, Lbstat, BC, T0.30H, T1.30H, B60, M9-stat, M40t90, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S542" upshifts 1559111 /Source="Nicolas_upshifts" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" S_feature 1559218..1559308 /Source="Nicolas_S_feature" /locus_tag="new_1559218_1559308" /HighExp="LBGstat, M0t90, LPhT, BC, UNK1, BI, Lbexp, LBGtran, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S543" upshifts 1559218 /Source="Nicolas_upshifts" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" promotor_-35 1559224..1559227 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1559242..1559258 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1559309..1560226 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protoheme IX farnesyltransferase 2" /protein_id="NP_389371.1" /db_xref="EnsemblGenomes-Gn:BSU14880" /db_xref="EnsemblGenomes-Tr:CAB13361" /db_xref="GOA:P24009" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG10214" /db_xref="UniProtKB/Swiss-Prot:P24009" /translation="MANSRILNDTAIDGQIEETTAWKDFLSLIKIGIVNSNLITTFTG MWLALHISGLSFLGNINTVLLTLIGSSLIIAGSCAINNWYDRDIDHLMERTKVRPTVT GKIQPSQALWSGILLVALGLIMLLMTTVMAAVIGFIGVFTYVVLYTMWTKRRYTINTV VGSVSGAVPPLIGWTAVEGNIGVVAWVLFMILFIWQIPHFLALAIKKTEDYRAANIPM LPVVYGFEVTKRQIIVWVACLMPLPFFLGSLGLPIVILGLLLNIGWLILGLMGFRSKN IMKWATQMFVYSLNYMTIYFVAMVVLTLF*" gene 1559309..1560226 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" downshifts 1560255 /Source="Nicolas_upshifts" /id="D844" /incds=0 /nref=33 /ntot=75 /MaxReadThrough="8.35391" /MaxDrop="5.6457" /score="0.893081758" /energy="-11.8" /TU="U1239,U1240" /idTUdmin="U1236" /TUdmin=1719 /isTUend="FALSE" upshifts 1560274 /Source="Nicolas_upshifts" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" misc_feature 1560275..1560280 /Source="Nicolas_upshift_promotors" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1560334..1560339 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1560354..1560372 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1560362..1560465 /Source="Nicolas_S_feature" /locus_tag="new_1560362_1560465" /HighExp="Lbstat, M0t90, M40t90, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, Sig-, SigA, SigA" /TUshortPSig="0.451, 0.407, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S544" upshifts 1560362 /Source="Nicolas_upshifts" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" CDS 1560466..1561536 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 9829923, 9882689, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 9829923, 9882689, 27503613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit II)" /protein_id="NP_389372.1" /db_xref="EnsemblGenomes-Gn:BSU14890" /db_xref="EnsemblGenomes-Tr:CAB13362" /db_xref="GOA:P24011" /db_xref="InterPro:IPR001505" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR014222" /db_xref="InterPro:IPR034236" /db_xref="InterPro:IPR036257" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10215" /db_xref="UniProtKB/Swiss-Prot:P24011" /translation="MVKHWRLILLLALVPLLLSGCGKPFLSTLKPAGEVADKQYDLTV LSTLIMVVVVAVVSVIFFYVIVRFRRSRVGENTIPKQVEGNKFLEITWTVIPILLLII LVIPVVLYTLELADTSPMDKKGRKAEDALVVNVRANLYWWEFEYPDYGIITSQELIVP TDQRVYFNLKASDVKHSFWIPSVGGKLDTNTDNENKFFLTFDSKRSKEAGDMFFGKCA ELCGPSHALMDFKVKTMSAKEFQGWTKEMKNYKSTAESDLAKQGEELFKEKNCLSCHA VEPNDKRAEAARTAPNLATFGERTKVAGVKEANKENVKAWLKDPDSIKPGNKMTGTYP KLSDSETNALYEYLKGLKAESK*" gene 1560466..1561536 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" CDS 1561569..1563437 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit I)" /protein_id="NP_389373.2" /db_xref="EnsemblGenomes-Gn:BSU14900" /db_xref="EnsemblGenomes-Tr:CAB13363" /db_xref="GOA:P24010" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014241" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10216" /db_xref="UniProtKB/Swiss-Prot:P24010" /translation="MLNALTEKRTRGSMLWDYLTTVDHKKIAILYLVAGGFFFLVGGI EAMFIRIQLAKPENAFLSAQAYNEVMTMHGTTMIFLAAMPLLFALMNAVVPLQIGARD VSFPFLNALGFWLFFFGGIFLNLSWFLGGAPDAGWTSYASLSLHSKGHGIDFFVLGLQ ISGLGTLIAGINFLATIINMRAPGMTYMRLPLFTWTTFVASALILFAFPPLTVGLALM MLDRLFGTNFFNPELGGNTVIWEHLFWIFGHPEVYILILPAFGIFSEVIPVFARKRLF GYSSMVFAIVLIGFLGFMVWVHHMFTTGLGPIANAIFAVATMAIAIPTGIKIFNWLLT IWGGNVKYTTAMLYAVSFIPSFVLGGVTGVMLAAAAADYQFHDTYFVVAHFHYVIIGG VVFGLLAGVHFWWPKMFGKILHETMGKISFVLFFIGFHLTFFIQHFVGLMGMPRRVYT FLPGQGLETGNLISTIGAFFMAAAVILLLVNVIWTSVKGEYVGADPWHDGRTLEWTVS SPPPEYNFKQLPFVRGLDPLWIEKQAGHKSMTPAEPVDDIHMPNGSILPLIISFGLFV AAFGLLYRSDYAWGLPVIFIGLGITFITMLLRSVIDDHGYHIHKEELPNDDKGVKA*" gene 1561569..1563437 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" CDS 1563437..1564060 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit III)" /protein_id="NP_389374.1" /db_xref="EnsemblGenomes-Gn:BSU14910" /db_xref="EnsemblGenomes-Tr:CAB13364" /db_xref="GOA:P24012" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10217" /db_xref="UniProtKB/Swiss-Prot:P24012" /translation="MQVQEKFTAETFPASPEKVTLEGKNKFLGFWLFLGGETVLFASL FATFLALRNSNAGDPPTTEMFDVTLVFIATMLLLTSSLTSVYAMYHMKNFSFGKMQLW LGITILLGAGFLGLEIYEFKHYTHEFGFTITSSALGSAFYTLVGTHGAHVAFGLMWIS TLMIRNAKRGLNLYTAPKFYVASLYWHFIDVVWVFIFTVVYLMGMVG*" gene 1563437..1564060 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" CDS 1564063..1564395 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit IV)" /protein_id="NP_389375.1" /db_xref="EnsemblGenomes-Gn:BSU14920" /db_xref="EnsemblGenomes-Tr:CAB13365" /db_xref="GOA:P24013" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014257" /db_xref="SubtiList:BG10218" /db_xref="UniProtKB/Swiss-Prot:P24013" /translation="MVDKKSRGHINSDLEFKKKKHAREMKYQVLSFGLMIGLTIVAFL TVATDGVGSWFTIPFIILLAAIQVIFQLYYFMHMNQKGHEAPALFLYSGVFVAFITVL AFVTIIWW*" gene 1564063..1564395 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" CDS 1564422..1565315 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" /function="16.10: Respire" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14766920, 15849754, 16305244, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14766920, 15849754, 16305244, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome aa(3) assembly factor" /protein_id="NP_389376.1" /db_xref="EnsemblGenomes-Gn:BSU14930" /db_xref="EnsemblGenomes-Tr:CAB13366" /db_xref="GOA:O34329" /db_xref="InterPro:IPR014108" /db_xref="InterPro:IPR019108" /db_xref="SubtiList:BG12579" /db_xref="UniProtKB/Swiss-Prot:O34329" /translation="MNQLEIFGFRAMWSPYLFCILLGITALYLYFYRRMSSKPNRITG KEMVCFLSAMLFLYAAEGSPVDLLGHIMFSAHMVQMAVLYLVVPPLLIAGIPAWLWEK IIFRPSIKPVFSFFTTPLIALLLFNGIFSLYHVPLIFDTVKTDPFYHTLITWLIFVLA FFMWWPLVHKVERLRQLSGLMKLGYIMADGMLLTPACALIMFSGAPLYATYTDPALWA EAMRLCVPADMMGQVPLTGPEMLNTLPLLEDQQLGAVMMKIIQEIVYGTFLAVIFFQW VKKEREKDGQEEPPYIQQTIS*" gene 1564422..1565315 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" downshifts 1565290 /Source="Nicolas_upshifts" /id="D845" /incds=0 /nref=121 /ntot=229 /MaxReadThrough="1.94099" /MaxDrop="5.91271" /score="4.35633365" /energy="-13.3" /TU="NA" /idTUdmin="U1239" /TUdmin=0 /isTUend="TRUE" CDS complement(1565347..1565709) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389377.1" /db_xref="EnsemblGenomes-Gn:BSU14940" /db_xref="EnsemblGenomes-Tr:CAB13367" /db_xref="InterPro:IPR014967" /db_xref="InterPro:IPR036491" /db_xref="SubtiList:BG13353" /db_xref="UniProtKB/Swiss-Prot:O34743" /translation="MLKFTESGLEGVKAELSWLDDLMESKGLIRAGQWDYERVTYDKK FSTIEGTFYLRIQGIAAEGDVGSGRAVIQLMSPLLGKHYYPHGVEYGETEEFPVQVVT KSKALIQDIANMLKTVQM*" gene complement(1565347..1565709) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" downshifts complement(1565366) /Source="Nicolas_upshifts" /id="D846" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="1.00586" /MaxDrop="6.68145" /score="-3.42191479" /energy="-11.2" /TU="NA" /idTUdmin="U1244" /TUdmin=0 /isTUend="TRUE" promotor_-35 1565702..1565706 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1565715..1565728 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1565733..1565752) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1565737..1565848 /Source="Nicolas_S_feature" /locus_tag="new_1565737_1565848" /HighExp="S7, S8, S4, S3, S6, S5, T5.0H, T4.0H, BC, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.368" /TUlongSig="NA" /TUlongPSig="NA" /label="S545" upshifts 1565737 /Source="Nicolas_upshifts" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" upshifts complement(1565745) /Source="Nicolas_upshifts" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" promotor_-35 complement(1565767..1565774) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1565849..1566295 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389378.2" /db_xref="EnsemblGenomes-Gn:BSU14950" /db_xref="EnsemblGenomes-Tr:CAB13368" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG13354" /db_xref="UniProtKB/Swiss-Prot:O34682" /translation="MTKIKDLMTADLQYCTVLDNVYEAAVKMKDANVGAIPVVDEDGE TLVGIVTDRDLVLRGIAIKKPNSQKITDAMTEKPVSVEEDASVDEVLHLMASHQLRRI PVTKNKKLTGIVTLGDLSLSEQTNERAGSALSDISEGDNREEGFFH*" gene 1565849..1566295 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" promotor_-35 1565881..1565888 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1565900..1565919 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1565905 /Source="Nicolas_upshifts" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" promotor_-35 1566304..1566311 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1566325..1566344 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1566336 /Source="Nicolas_upshifts" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" CDS 1566379..1567419 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389379.1" /db_xref="EnsemblGenomes-Gn:BSU14960" /db_xref="EnsemblGenomes-Tr:CAB13369" /db_xref="GOA:O34586" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR029410" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13355" /db_xref="UniProtKB/Swiss-Prot:O34586" /translation="MKNILRAMVILLIICGTYVLFIQYGSVPEKKSNDSEPQVSNEEA QSGKRIHMPTSGLLSFMGKHADEVTKKLGEPERIDPSAYDYDWWVYNQGKDQYIQIGV LNNKVVTLFASGNDINAKPFKIGESTGEVFKTTQVAPFVNVEYKGNSYRFEFSEEDIN TRPTVKVGKMYVQLYMDKFEGKLSSIRAFDAQTFVKQRPYEVVYRGELIKPKAVSDEK WKKIQTTSEKQILDLTNVIRVKHGLAKLEWDQPTAEVAFGHSEDMKENNYFSHVSKKY GSLKDRLEEGHVDFQQAGENIAYNYVDGPAAVEGWLNSEGHRKALLNSDYTHLGVGVD RKYYTQNFIKRW*" gene 1566379..1567419 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" promotor_-10 complement(1567342..1567360) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1567347) /Source="Nicolas_upshifts" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1567376..1567381) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1567399 /Source="Nicolas_upshifts" /id="D847" /incds=0 /nref=84 /ntot=252 /MaxReadThrough="1.59604" /MaxDrop="4.17709" /score="-1.16631837" /energy="-8.1" /TU="NA" /idTUdmin="U1243" /TUdmin="-4" /isTUend="TRUE" promotor_-35 1567583..1567592 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1567606..1567625 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1567620 /Source="Nicolas_upshifts" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" CDS 1567651..1568049 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19775244, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related protein (coat)" /protein_id="NP_389380.1" /db_xref="EnsemblGenomes-Gn:BSU14970" /db_xref="EnsemblGenomes-Tr:CAB13370" /db_xref="InterPro:IPR025953" /db_xref="SubtiList:BG13356" /db_xref="UniProtKB/Swiss-Prot:O34880" /translation="MANQHANHSINDFKQFVKKHPKLIKEVRKEQRSWQDVYENWVLF GESDPIWDPYREPEEASEAVPETPQKNDFVSKMVTAVKKMDVNQMNEQINKMSQSISS LQSLLNTFSGSGQKHSQPGSGQHPFSFRKD*" gene 1567651..1568049 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" downshifts complement(1567655) /Source="Nicolas_upshifts" /id="D848" /incds=0 /nref=2 /ntot=11 /MaxReadThrough="2.37349" /MaxDrop="4.0378" /score="40.2648817" /energy="-14.3" /TU="NA" /idTUdmin="U1247" /TUdmin="-374" /isTUend="FALSE" CDS 1568065..1568304 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389381.1" /db_xref="EnsemblGenomes-Gn:BSU14980" /db_xref="EnsemblGenomes-Tr:CAB13371" /db_xref="InterPro:IPR025613" /db_xref="SubtiList:BG13357" /db_xref="UniProtKB/Swiss-Prot:O34958" /translation="MRKEVQEYILANEERKRFIREQPIWYRRLSRKPDDLSSFQLEMM NFYEKTIPHRVNQFTNGIQMAQMMMQMFQAMRTKD*" gene 1568065..1568304 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" downshifts 1568283 /Source="Nicolas_upshifts" /id="D849" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="2.09257" /MaxDrop="4.65792" /score="-7.8200921" /energy="-5.1" /TU="NA" /idTUdmin="U1248" /TUdmin=0 /isTUend="TRUE" promotor_-35 1568371..1568378 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1568389..1568408 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1568394 /Source="Nicolas_upshifts" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" CDS 1568420..1568869 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex controlling RNase Y (RicAFTcomplex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389382.1" /db_xref="EnsemblGenomes-Gn:BSU14990" /db_xref="EnsemblGenomes-Tr:CAB13372" /db_xref="GOA:O34412" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="SubtiList:BG13358" /db_xref="UniProtKB/Swiss-Prot:O34412" /translation="MYATMESVRLQSEAQQLAEMILQSETAENYRNCYKRLQEDEEAG RIIRSFIKIKEQYEDVQRFGKYHPDYREISRKMREIKRELDLNDKVADFKRAENELQS ILDEVSVEIGTAVSEHVKVPTGNPYFDGLSSCGGGCGSGGSCGCKVS*" gene 1568420..1568869 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" downshifts 1568855 /Source="Nicolas_upshifts" /id="D850" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="5.95111" /MaxDrop="2.83" /score="-4.2014677" /energy="-11.5" /TU="U1249" /idTUdmin="U1248" /TUdmin=572 /isTUend="FALSE" CDS 1568924..1569196 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10712692, 21532344, 22333191" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389383.1" /db_xref="EnsemblGenomes-Gn:BSU15000" /db_xref="EnsemblGenomes-Tr:CAB13373" /db_xref="GOA:O34658" /db_xref="InterPro:IPR016979" /db_xref="SubtiList:BG13359" /db_xref="UniProtKB/Swiss-Prot:O34658" /translation="MENRRQGMVVYLHSLKQSKMLRKFGNVHYVSKRLKYVVLYCDMD QIEKTMDKIASYSFVKKVEPSYKPFLKLEFESKLDKAKEYDYKIGI*" gene 1568924..1569196 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" S_feature complement(1569001..1569224) /Source="Nicolas_S_feature" /locus_tag="new_1569001_1569224_c" /HighExp="S8, S7, S4, S5, S6, S3, C30, BT, G135, C90" /AntisenseName="ylbG" /AntisenseCor="-0.668594452827031" /AntisenseRegPval="-35.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S546" misc_RNA 1569199..1569319 /gene="csfG" /locus_tag="BSU_misc_RNA_23" /product="sporulation-specific regulatory RNA" /experiment="publication(s) with functional evidences, PMID:21532344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21532344; Product type n: RNA" /function="15.7: Sporulation and germination" gene 1569199..1569319 /gene="csfG" /locus_tag="BSU_misc_RNA_23" S_feature complement(1569226..1569349) /Source="Nicolas_S_feature" /locus_tag="new_1569226_1569349_c" /HighExp="S3, S8, S7, G/S, S4, S5, Pyr, S6, B36, BT" /AntisenseName="NA" /AntisenseCor="-0.69279578575099399" /AntisenseRegPval="-39.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S547" downshifts complement(1569269) /Source="Nicolas_upshifts" /id="D851" /incds=0 /nref=61 /ntot=131 /MaxReadThrough="3.9368" /MaxDrop="7.78892" /score="40.2648817" /energy="-14.3" /TU="U1250" /idTUdmin="U1250" /TUdmin="-228" /isTUend="FALSE" S_feature 1569320..1569425 /Source="Nicolas_S_feature" /locus_tag="new_1569320_1569425" /HighExp="H2O2, Paraq, Oxctl, G180, G135, G150, Cold, C30, Diami, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S548" promotor_-10 complement(1569350..1569362) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1569357) /Source="Nicolas_upshifts" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" promotor_-35 complement(1569377..1569383) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1569406..1569410 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-35" promotor_-10 1569426..1569445 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-10" S_feature 1569427..1569518 /Source="Nicolas_S_feature" /locus_tag="new_1569427_1569518" /HighExp="H2O2, G135, Oxctl, Paraq, G180, dia0, G150, Lbexp, LBGexp, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S549" upshifts 1569427 /Source="Nicolas_upshifts" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" CDS 1569519..1570073 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" /EC_number="2.1.1.171" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 17389639, 22535590, 22649054; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m2G966 methyltransferase" /protein_id="NP_389384.2" /db_xref="EnsemblGenomes-Gn:BSU15010" /db_xref="EnsemblGenomes-Tr:CAB13374" /db_xref="GOA:O34331" /db_xref="InterPro:IPR004398" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13360" /db_xref="UniProtKB/Swiss-Prot:O34331" /translation="MRVISGSKKGRSLKAVAGTSTRPTTDKVKESIFNMIGPYFDGGR GLDLFAGSGGLGIEALSRGFEHCIFVDRDFKAIQTVKSNLKTLELTKHAQVYRNDAER ALHAAAKRETGFRGIFLDPPYKEQKLKALLTLIDEYQMLEEDGFIVAEHDREVELPET VGDLVMTRKETYGLTGVAIYKKRG*" gene 1569519..1570073 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" CDS 1570078..1570563 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" /EC_number="2.7.7.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10480925, 10939241, 16014871, 21912874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphopantetheine adenylyltransferase" /protein_id="NP_389385.1" /db_xref="EnsemblGenomes-Gn:BSU15020" /db_xref="EnsemblGenomes-Tr:CAB13375" /db_xref="GOA:O34797" /db_xref="InterPro:IPR001980" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="PDB:1O6B" /db_xref="SubtiList:BG13361" /db_xref="UniProtKB/Swiss-Prot:O34797" /translation="MASIAVCPGSFDPVTYGHLDIIKRGAHIFEQVYVCVLNNSSKKP LFSVEERCELLREVTKDIPNITVETSQGLLIDYAKRKNAKAILRGLRAVSDFEYEMQG TSVNRVLDESIETFFMMTNNQYSFLSSSIVKEVARYNGSVSEFVPPEVELALQQKFRQ G*" gene 1570078..1570563 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" downshifts 1570530 /Source="Nicolas_upshifts" /id="D852" /incds=0 /nref=26 /ntot=196 /MaxReadThrough="3.45558" /MaxDrop="3.85134" /score="13.7782945" /energy="-7.8" /TU="U1249,U1251" /idTUdmin="U1251" /TUdmin="-1296" /isTUend="FALSE" CDS complement(1570574..1571800) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15849754, 16850406, 28945739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15849754, 16850406, 28945739; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipicolinic acid transporter (to the spore)" /protein_id="NP_389386.1" /db_xref="EnsemblGenomes-Gn:BSU15030" /db_xref="EnsemblGenomes-Tr:CAB13376" /db_xref="GOA:O34765" /db_xref="InterPro:IPR011642" /db_xref="InterPro:IPR014226" /db_xref="SubtiList:BG13362" /db_xref="UniProtKB/Swiss-Prot:O34765" /translation="MNLSKINTLLIASFFLFLTATVISHPQASFEASKTGLSMWWEVV FPSLLPFFILSELLIGFGIVRFVGVLLEPFMRPIFRVPGVGGFVLAMGMASGNPAGAK LTARLRQENQISRVEAERLASFTNSSNPLFIFGAVAVGFFQNASLGILLASAHYLGNL AVGLTMRSYGRKEEQHLRRKKTIPFPSVKDALHALHTARLAEKRPLGKILGDAVTSSV QTLLMVGGFIILFSVFNRLLSVVQLTDVLSVFTKGALTLFQLPTQLDIPLLSGMFEIT LGSKLVSETDVSLLQKAIIVSFILGFSGFSVQAQVAGILSETDIRFKPFFIARLLQGV YAAVFVMLLWKPLYTAWHDPYQYVFKSLNSSDMSTAFINGWNLLVQIGPAVTLCALFT YIIIFSYRLTNGTKKG*" gene complement(1570574..1571800) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" S_feature 1570575..1571849 /Source="Nicolas_S_feature" /locus_tag="new_1570575_1571849" /HighExp="H2O2, G135, Paraq, G150, G180, Oxctl, LBGexp, dia0, dia15, Mt0" /AntisenseName="ylbJ" /AntisenseCor="-0.54237424349391605" /AntisenseRegPval="-21.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S550" S_feature complement(1571801..1571902) /Source="Nicolas_S_feature" /locus_tag="new_1571801_1571902_c" /HighExp="LoTm, S3, S4, S5, T5.0H, M9-stat, T4.0H, S6, BT, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S551" promotor_-35 1571824..1571831 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1571843..1571862 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1571851..1571980 /Source="Nicolas_S_feature" /locus_tag="new_1571851_1571980" /HighExp="Etha, dia15, dia5, Diami, H2O2, Lbtran, LBGtran, Paraq, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S552" upshifts 1571851 /Source="Nicolas_upshifts" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" promotor_-10 complement(1571897..1571915) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1571912) /Source="Nicolas_upshifts" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" promotor_-35 complement(1571932..1571937) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1571981..1572763 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389387.1" /db_xref="EnsemblGenomes-Gn:BSU15040" /db_xref="EnsemblGenomes-Tr:CAB13377" /db_xref="GOA:O34731" /db_xref="InterPro:IPR001423" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG13363" /db_xref="UniProtKB/Swiss-Prot:O34731" /translation="MAKPKIGLALGSGGARGLAHLGVLSSLHKHQIEVDMIAGSSMGA LVGSFYAAGHDVATMKKVAKAFKRRLYADYTVPKLGFLKGDRVRQLVHAYTFGKPIEE LQIPLGIVACDLQTGEKIVFRKGSVSDAVRASISIPGIFIPQRLDGRLLVDGAVVDRI PVSVVKDMGADIIIASDVSRVRKTETAVHIFDVIMQSMDILQNELVRHQTIAADIMIR PSLETYSSSSFANIEEMISAGEEATNRMISKIRKEIENWEGS*" gene 1571981..1572763 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" promotor_-35 1572543..1572549 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1572563..1572574 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1572574 /Source="Nicolas_upshifts" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" CDS 1572765..1573790 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradative enzyme" /protein_id="NP_389388.2" /db_xref="EnsemblGenomes-Gn:BSU15050" /db_xref="EnsemblGenomes-Tr:CAB13378" /db_xref="GOA:O34470" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR036034" /db_xref="PDB:2KJP" /db_xref="SubtiList:BG13364" /db_xref="UniProtKB/Swiss-Prot:O34470" /translation="MLRKKHFSWMLVILILIAVLSFIKLPYYITKPGEATELASLIKV EGGYPEKGSLSLMTVKVGPANPFTYVWAKMHPYYEIVPDESIKEEGESDKEYMKRQLQ MMKSSQENAVIAAYQKAGKKVSYSFNGIYASSVVENMPAKGKIEVGDKIISADGKNYQ SAEKLIDYISSKKAGDKVTLKIEREEKEKRVTLTLKQFPDEPDRAGIGVSLYTDRNVK VEPDIDFEIENIGGPSAGLMMSLEIYNQLTKPDETKGYDIAGTGTIDVDGKVGPIGGI DQKVVAADKAGKDIFFAPNQNGASNSDYKNAVKTAKDIDSNMKIVPVDTMQDAIDYLN KLKAKST*" gene 1572765..1573790 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" downshifts 1573674 /Source="Nicolas_upshifts" /id="D853" /incds=1 /nref=59 /ntot=235 /MaxReadThrough="2.38639" /MaxDrop="3.52503" /score="19.0874959" /energy="-11.5" /TU="NA" /idTUdmin="U1249" /TUdmin=0 /isTUend="TRUE" CDS complement(1573807..1575054) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 19215769; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative component of the degradosome" /protein_id="NP_389389.1" /db_xref="EnsemblGenomes-Gn:BSU15060" /db_xref="EnsemblGenomes-Tr:CAB13379" /db_xref="InterPro:IPR008513" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13365" /db_xref="UniProtKB/Swiss-Prot:O34513" /translation="MKAVGLVVEYNPFHNGHLYHAQTAKLQTGCDTAVAVMSGHFLQR GEPAVVSKWARTKMALQSGVDLVIELPYLYAVQKADIFARGSVSILNELECEALFFGS ENGDIKPFLETAQLIDEHKHILNDRIKEELKKGASYPAAAAIAFSSILHTESALDLSK PNNILGYQYVTSILTGGYPMKPYTTARISSDYHDADLPEGENHIASATSIRKAMIGQN LEACLRFLPAASARELAAYRKSFGLWHTPESYFSYLKYSLSTVTARELQQVYEVEEGL EHRIIRSIRKSSSYQEFMELLKTKRYTWTRLQRMNTHILTRTKKQDMQKLLDNDKAPY IRLLGMTKKGQAYLSEKKKALSVPLVSKLSSFSHPALDLDVKASRIYSLPIEEPLRTE FDLQEYGHAPIRYDEDEQHFLNV*" gene complement(1573807..1575054) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" downshifts complement(1573834) /Source="Nicolas_upshifts" /id="D854" /incds=0 /nref=8 /ntot=182 /MaxReadThrough="1.58661" /MaxDrop="3.70777" /score="4.49214865" /energy="-11.5" /TU="NA" /idTUdmin="U1257" /TUdmin=775 /isTUend="FALSE" promotor_-35 1574971..1574977 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-35" promotor_-10 1574991..1575002 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-10" upshifts 1574995 /Source="Nicolas_upshifts" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" CDS complement(1575051..1575236) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein,of unknown function" /protein_id="YP_003097727.1" /db_xref="EnsemblGenomes-Gn:BSU15069" /db_xref="EnsemblGenomes-Tr:CAX52618" /db_xref="UniProtKB/Swiss-Prot:C0H411" /translation="MIIAFKIVFVNIFSLQHNAAIEVSLTAEYAMHTLKTKIRRKSFH LQMYHTFLNIARKAEKI*" gene complement(1575051..1575236) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" promotor_-35 1575069..1575073 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-35" promotor_-10 1575089..1575108 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-10" S_feature 1575098..1575233 /Source="Nicolas_S_feature" /locus_tag="new_1575098_1575233" /HighExp="Cold, LoTm, Diami, Paraq, H2O2, Oxctl, G180, dia5, G135, LBGexp" /AntisenseName="ylzH" /AntisenseCor="-9.1134498265910996E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S553" upshifts 1575098 /Source="Nicolas_upshifts" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" promotor_-10 complement(1575127..1575146) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1575137) /Source="Nicolas_upshifts" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" promotor_-35 complement(1575160..1575167) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1575204..1575211 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1575225..1575244 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1575235 /Source="Nicolas_upshifts" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" CDS 1575264..1575782 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11700356, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389390.1" /db_xref="EnsemblGenomes-Gn:BSU15070" /db_xref="EnsemblGenomes-Tr:CAB13380" /db_xref="InterPro:IPR003772" /db_xref="SubtiList:BG13366" /db_xref="UniProtKB/Swiss-Prot:O34445" /translation="MKWTIYQLHQMPKQSFEFDETVELNELTKLNSDIRRISPVRVKG RADIKSKQVSFDFTISGEMLLPCSRTLVDVPYPFEISTKELFIFHHTDDIEDDDVHIV EDDTIDITPIVKEEILLEIPMQIFCESEQEKGAAPQEGKDWQVISEEDKKNQVDPRLA ALEKLLKQDDES*" gene 1575264..1575782 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" CDS 1575804..1575983 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L32" /protein_id="NP_389391.1" /db_xref="EnsemblGenomes-Gn:BSU15080" /db_xref="EnsemblGenomes-Tr:CAB13381" /db_xref="GOA:O34687" /db_xref="InterPro:IPR002677" /db_xref="InterPro:IPR011332" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12668" /db_xref="UniProtKB/Swiss-Prot:O34687" /translation="MAVPFRRTSKMKKRLRRTHFKLNVPGMTECPSCGEMKLSHRVCK ACGSYNGKDINVKSN*" gene 1575804..1575983 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" downshifts 1575963 /Source="Nicolas_upshifts" /id="D855" /incds=0 /nref=232 /ntot=266 /MaxReadThrough="5.64002" /MaxDrop="7.70407" /score="53.0065581" /energy="-17.1" /TU="U1258" /idTUdmin="U1256" /TUdmin=0 /isTUend="TRUE" upshifts complement(1576006) /Source="Nicolas_upshifts" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(1576010..1576013) /Source="Nicolas_upshift_promotors" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1576064..1576069 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1576085..1576103 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1576086 /Source="Nicolas_upshifts" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" CDS 1576129..1576710 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15621419, 20435725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15621419, 20435725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="DNA-binding regulator" /protein_id="NP_389392.1" /db_xref="EnsemblGenomes-Gn:BSU15090" /db_xref="EnsemblGenomes-Tr:CAB13382" /db_xref="GOA:O34549" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017930" /db_xref="SubtiList:BG13367" /db_xref="UniProtKB/Swiss-Prot:O34549" /translation="MTITRQDAWTQDEDLLLAEVVLRHIREGGTQLSAFEEVGRALTR TAAACGFRWNSYVRKQYQSGIELAKKQRKELRKQIGVHSVNMPNSMKQTASASSEGKR DLSIQDVIQFLEQFKETPSAQEFQLEREKLKEQIQSLQKELEDLRSENQTLRNQLEMT EEDYKALIDIMDRARKMVVSKEDGRMKKAAQET*" gene 1576129..1576710 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" downshifts 1576711 /Source="Nicolas_upshifts" /id="D856" /incds=0 /nref=56 /ntot=139 /MaxReadThrough="2.70626" /MaxDrop="5.6861" /score="-7.71867756" /energy="-12.8" /TU="U1260" /idTUdmin="U1258" /TUdmin=0 /isTUend="TRUE" CDS complement(1576767..1577249) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389393.2" /db_xref="EnsemblGenomes-Gn:BSU15100" /db_xref="EnsemblGenomes-Tr:CAB13383" /db_xref="GOA:O34468" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017274" /db_xref="PDB:2PR1" /db_xref="SubtiList:BG13368" /db_xref="UniProtKB/Swiss-Prot:O34468" /translation="MTKVERLLINYKTLEEFKKFKEYGIQELSMLEELQDNIIENDST SPFYGIYFGDKLVARMSLYQVNGKSNPYFDNRQDYLELWKLEVLPGYQNRGYGRALVE FAKSFKMPIRTNPRMKSAEFWNKMNFKTVKYDMARDKGENPLIWHPDMDREMTPGESA *" gene complement(1576767..1577249) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" downshifts complement(1576786) /Source="Nicolas_upshifts" /id="D857" /incds=0 /nref=90 /ntot=231 /MaxReadThrough="3.90092" /MaxDrop="6.59996" /score="14.5482917" /energy="-14.5" /TU="U1261" /idTUdmin="U1261" /TUdmin="-615" /isTUend="FALSE" downshifts 1577239 /Source="Nicolas_upshifts" /id="D858" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="3.3013" /MaxDrop="4.42908" /score="-7.71867756" /energy="-12.8" /TU="NA" /idTUdmin="U1260" /TUdmin=418 /isTUend="FALSE" promotor_-10 complement(1577272..1577291) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1577291) /Source="Nicolas_upshifts" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" promotor_-35 complement(1577305..1577312) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1577349..1577355 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-35" promotor_-10 1577367..1577386 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-10" upshifts 1577369 /Source="Nicolas_upshifts" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" CDS 1577409..1578305 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1844812, 10736170, 23894131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1844812, 10736170, 23894131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate 2-reductase" /protein_id="NP_389394.1" /db_xref="EnsemblGenomes-Gn:BSU15110" /db_xref="EnsemblGenomes-Tr:CAB13384" /db_xref="GOA:O34661" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="PDB:3EGO" /db_xref="SubtiList:BG13369" /db_xref="UniProtKB/Swiss-Prot:O34661" /translation="MKIGIIGGGSVGLLCAYYLSLYHDVTVVTRRQEQAAAIQSEGIR LYKGGEEFRADCSADTSINSDFDLLVVTVKQHQLQSVFSSLERIGKTNILFLQNGMGH IHDLKDWHVGHSIYVGIVEHGAVRKSDTAVDHTGLGAIKWSAFDDAEPDRLNILFQHN HSDFPIYYETDWYRLLTGKLIVNACINPLTALLQVKNGELLTTPAYLAFMKLVFQEAC RILKLENEEKAWERVQAVCGQTKENRSSMLVDVIGGRQTEADAIIGYLLKEASLQGLD AVHLEFLYGSIKALERNTNKVF*" gene 1577409..1578305 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" CDS 1578376..1579995 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" /EC_number="6.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16169927, 19578333, 20308541, 20799687, 25496067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16169927, 19578333, 20308541, 20799687, 25496067; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate glucosamine cysteine ligase" /protein_id="NP_389395.2" /db_xref="EnsemblGenomes-Gn:BSU15120" /db_xref="EnsemblGenomes-Tr:CAB13385" /db_xref="GOA:P55342" /db_xref="InterPro:IPR011199" /db_xref="PDB:4WBD" /db_xref="SubtiList:BG11424" /db_xref="UniProtKB/Swiss-Prot:P55342" /translation="MQLTELSIKNQNVFVQHYIDGKEEMSSFFDYSIHHKDMWRERLE DLSSRFFAREELAAYLTSYHNKFGSSAMQSAIEKLKDPSSAAVVGGQQAGLLTGPLYT IHKIISIIVLAKQQEKELQVPVIPIFWVAGEDHDLDEINFVHTSEENGPVKKKLPQSY WKKSSAASTSLDQEKCAAWIDDVFAAFEETDHTNTLLDNVKRCLRESVTFTDFFELLI ADLFQEEGLVLLNSGDPGIKKLETAMFQKILRENDELARAVSDQQAFMRQAGYKPIIE SGKEQANLFYEYEDERFLIEKDNGRFVIKELDLGWTRDELHTHMEEHPERFSNNVVTR PLMQEFLIPTLAFIAGPGEINYWGELKQAFAVMGFKMPPVMPRLNITILERHIEKKLA ERNISLQDAIERGTENQRETYFERQIPEEFTAVMDQAKSQIEAIHKTVRQEALKVDQS LEPLLLKNAAFIQDQLQFLERTVMKRIEEKEGYVLKDYERIQNSIKPLLAPQERIWNI MYYLNRYGPKFFTTFKNLPFSFQNQHQVVKL*" gene 1578376..1579995 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" downshifts 1579967 /Source="Nicolas_upshifts" /id="D859" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="3.87099" /MaxDrop="3.76832" /score="34.9463932" /energy="-8.3" /TU="U1262" /idTUdmin="U1262" /TUdmin="-66" /isTUend="FALSE" promotor_-35 1580029..1580032 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1580047..1580120 /Source="Nicolas_S_feature" /locus_tag="new_1580047_1580120" /HighExp="M9-stat, T5.0H, T3.0H, Lbstat, Lbtran, T2.30H, T1.30H, M0t90, T1.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="SigA" /TUlongPSig=1 /label="S554" promotor_-10 1580047..1580066 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1580047 /Source="Nicolas_upshifts" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" downshifts complement(1580104) /Source="Nicolas_upshifts" /id="D860" /incds=0 /nref=17 /ntot=137 /MaxReadThrough="3.30554" /MaxDrop="4.47473" /score="-9.92306593" /energy="-12" /TU="NA" /idTUdmin="U1264" /TUdmin=1149 /isTUend="FALSE" CDS 1580121..1580552 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" /function="16.13: Shape" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10572301, 15939023, 16511046, 24659771, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of RsmH and transcriptional regulator" /protein_id="NP_389396.1" /db_xref="EnsemblGenomes-Gn:BSU15130" /db_xref="EnsemblGenomes-Tr:CAB13386" /db_xref="GOA:P55343" /db_xref="InterPro:IPR003444" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR020603" /db_xref="InterPro:IPR035642" /db_xref="InterPro:IPR035644" /db_xref="SubtiList:BG11425" /db_xref="UniProtKB/Swiss-Prot:P55343" /translation="MFMGEYQHTIDAKGRMIVPAKFREGLGEQFVLTRGLDQCLFGYP MHEWKQIEEKLKALPLTKKDARAFTRFFFSGATECELDKQGRVNIASSLLNYAKLEKE CVVIGVSNRIELWSKVIWEQYTEEQEDSFAEIAENMIGFDI*" gene 1580121..1580552 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" CDS 1580622..1581557 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" /EC_number="2.1.1.199" /function="16.6: Maintain" /function="16.13: Shape" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9294438, 9721276, 10572301, 16849811, 19965768, 20924196, 22561317, 27711192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m4C1402 methyltransferase" /protein_id="NP_389397.1" /db_xref="EnsemblGenomes-Gn:BSU15140" /db_xref="EnsemblGenomes-Tr:CAB13387" /db_xref="GOA:Q07876" /db_xref="InterPro:IPR002903" /db_xref="InterPro:IPR023397" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10219" /db_xref="UniProtKB/Swiss-Prot:Q07876" /translation="MFQHKTVLLRETVDGLNIKPDGTYVDCTLGGAGHSTYLLQQLSE KGRLIAFDQDDTALQHAKEVLSDYKGQLILIKSNFRYLKEYLNEQGVTEVDGILFDLG VSSPQLDTPERGFSYHHDAPLDMRMDQSATLSAKEVVNEWRYEDLVRIFFKYGEEKFS KQIARKIEEARMKSPIQTTGQLVDLIKDAIPAPARRSGGHPAKRVFQAIRIAVNDELR VFEEALEQAIEVLKPGGRVSVITFHSLEDRICKTTFKEKSSLPELPPGLPVIPEEFEP ELKLITRKPITASQEELEENNRARSAKLRIAEKRK*" gene 1580622..1581557 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" S_feature complement(1581224..1582676) /Source="Nicolas_S_feature" /locus_tag="new_1581224_1582676_c" /HighExp="Salt, Sw, B60, Etha, M9-stat, Gly, C30, LPhT, BC, B36" /AntisenseName="ftsL" /AntisenseCor="-0.195961042435877" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S555" CDS 1581597..1581950 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein" /protein_id="NP_389398.1" /db_xref="EnsemblGenomes-Gn:BSU15150" /db_xref="EnsemblGenomes-Tr:CAB13388" /db_xref="GOA:Q07867" /db_xref="InterPro:IPR011922" /db_xref="SubtiList:BG10220" /db_xref="UniProtKB/Swiss-Prot:Q07867" /translation="MSNLAYQPEKQQRHAISPEKKVIVKKRASITLGEKVLLVLFAAA VLSVSLLIVSKAYAAYQTNIEVQKLEEQISSENKQIGDLEKSVADLSKPQRIMDIAKK NGLNLKDKKVKNIQE*" gene 1581597..1581950 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" CDS 1581947..1584097 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8636036, 10411726, 12682299, 14731276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636036, 10411726, 12682299, 14731276; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2B" /protein_id="NP_389399.2" /db_xref="EnsemblGenomes-Gn:BSU15160" /db_xref="EnsemblGenomes-Tr:CAB13389" /db_xref="GOA:Q07868" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10221" /db_xref="UniProtKB/Swiss-Prot:Q07868" /translation="MIQMPKKNKFMNRGAAILSICFALFFFVILGRMAYIQITGKANG EVLATKATEQHEKKRTIEASRGSILDRKGKVIAEDTATYKLIAILDKKMTTDVKHPQH VVNKEKTAEALSKVINLDKADILDILNKDAKQVEFGSAGRDITYSQKQKIEKMKLPGI SFLRDTKRYYPNGVFASNLIGYAEVDEETNEISGAMGLEKVLDKYLKERDGYVTYESD KSGWELPNSKNKITAPKNGDNVYLTIDQKIQTFLEDSMTKVAQKYNPKKIMAAVVDPK TGKVLAMGQRPSFDPNKRDVTNYYNDLISYAYEPGSTMKIFTLAAAMQENVFNANEKY KSGTFEVGGAPVKDHNNGVGWGPTTYHDGVLRSSNVAFAKLAKEKLGYDRLNQYLHKF NFYQKTGIDLPGEVSSKINFKYEFDKASTAYGQASAVTPIQQIQAATAIANDGKMMKP YVIDHIVDPDKDKTIYQNKPESAGTPISASTAKKVRDILGEVVTSKIGTGQAYKIEGF DVAGKTGTAQIAGKGGYLDGTDNYIFSFMGMAPKDDPELLIYVAVQQPQLKAGQSSSD PVSEIFNPTMKNSLHYLNIEPTEKSDSDKEETKAQTMPDLTDQTVAAAQKKAKEENLT PIVIGSDVAVKEQYPKADEEVLTNQKVFLKTGGKIKMPDMTGWSRREVLQYGELAGIH IEVSGQGYAVSQSVKKDKEIKDKTVIKVKFKNPD*" gene 1581947..1584097 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" promotor_-10 complement(1582657..1582675) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1582676) /Source="Nicolas_upshifts" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" promotor_-35 complement(1582690..1582696) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1584080 /Source="Nicolas_upshifts" /id="D861" /incds=0 /nref=237 /ntot=257 /MaxReadThrough="1.141" /MaxDrop="6.28059" /score="3.41058446" /energy="-7.4" /TU="NA" /idTUdmin="U1263" /TUdmin="-1" /isTUend="TRUE" promotor_-35 1584152..1584157 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-35" promotor_-10 1584173..1584191 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-10" upshifts 1584173 /Source="Nicolas_upshifts" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" CDS 1584214..1586154 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8244929, 8289242, 9006059, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8244929, 8289242, 9006059, 28383125; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transpeptidase penicillin-binding protein" /protein_id="NP_389400.2" /db_xref="EnsemblGenomes-Gn:BSU15170" /db_xref="EnsemblGenomes-Tr:CAB13390" /db_xref="GOA:Q03524" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR011927" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10222" /db_xref="UniProtKB/Swiss-Prot:Q03524" /translation="MRVSNVTVRKRLLFVLLFGVIVFLIIDTRLGYVQFVMGEKLTSL AKDSWSRNLPFEPERGEILDRNGVKLATNKSAPTVFVVPRQVQNPMKTSKQLAAVLNM SEEKVYKHVTKKASIEKITPEGRKISNEKAKEIKALDLKGVYVAEDSIRHYPFGSFLS HVLGFAGIDNQGLLGLEAYYDDDLKGEKGSVKFYTDAKGKKMPDEADDYTPPKDGLDM KLTVDSKVQTIMERELDNAEAKYHPDGMIAVAMNPKNGEILGMSSRPDFDPADYQSVD PSVYNRNLPVWSTYEPGSTFKIITLAAALEEQKVNLKRDQFYDKGHAEVDGARLRCWK RGGHGLQTYLEVVQNSCNPGFVELGERLGKEKLFKYIKDFGFGQKTGIDLQGEGTGIL FPLERVGPVEQATTAFGQGVSVTPIQQVAAVSAAVNGGTLYTPYIAKEWIDPVTKKTV KKQSPIAKKQVISEETSKQIRYALESVVAEGTGRNAFVEGYRVGGKTGTAQKVKDGKY LENNHIVSFIGFAPADDPSLVVYVAVDNPKGTIQFGGTVAAPIVGNIMRDSLPELGVK PRKNQIEKKYQWNDTKTIEVPNVVGMSVSDLESLLVNLNVDASGKGSKIVKQSPAAGT KVKEGSKIRVYLTEEDEKEAAD*" gene 1584214..1586154 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" promotor_-35 1585950..1585956 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-35" promotor_-10 1585971..1585979 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-10" upshifts 1585977 /Source="Nicolas_upshifts" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" downshifts 1586127 /Source="Nicolas_upshifts" /id="D862" /incds=0 /nref=19 /ntot=91 /MaxReadThrough="4.23549" /MaxDrop="4.37308" /score="-3.90592085" /energy="-13.6" /TU="U1265,U1266" /idTUdmin="U1265" /TUdmin="-91" /isTUend="FALSE" S_feature 1586172..1586239 /Source="Nicolas_S_feature" /locus_tag="new_1586172_1586239" /HighExp="C30, G180, G135, ferm, MG 15, G150, MG 45, MG-0.1, MG 10, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S556" promotor_-35 1586209..1586213 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1586229..1586248 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" S_feature 1586241..1586329 /Source="Nicolas_S_feature" /locus_tag="new_1586241_1586329" /HighExp="G180, G150, LBGexp, Paraq, G135, Oxctl, C30, dia0, Cold, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S557" upshifts 1586241 /Source="Nicolas_upshifts" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" CDS 1586330..1587814 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" /EC_number="6.3.2.13" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8436954, 10520745, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate-2, 6-diaminopimelate ligase" /protein_id="NP_389401.1" /db_xref="EnsemblGenomes-Gn:BSU15180" /db_xref="EnsemblGenomes-Tr:CAB13391" /db_xref="GOA:Q03523" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005761" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10223" /db_xref="UniProtKB/Swiss-Prot:Q03523" /translation="MKLTKLLTYLTTEPSVNDSQDPEITSIEMDSREVKKGSLFVCVK GYTVDGHDFAQKAVENGAAAIVAEREVDVNVPVIIVRQSLRALSVLSDAFYGQPTKKL QLIGITGTNGKTSTTHMVDEILKKAGKRTGLIGTMYMKIGDETLPVKNTTPESVTLQK TFKKMNDKHVDTAIMEVSSHALSLGRVHGCDYDIAVFTNLTQDHLDYHKTMDEYRHAK SLLFSQLGGAFNHEHPKRAVLNADDEASAYFEKVTAAHISTYGIKNDADVMAKNISIT AQGTSFDLVTNKGTKHITMSLVGQFNVYNVLAAVATCIAAGIPFEIITEAVEELHGVR GRFELVNQQQEFPVIVDYAHTPDSLENVLETCRDMTEGKLFVVVGCGGDRDKTKRPKM AKIAVELADEPIFTSDNPRSEDPRAILRDMEAGVENAYYHSIANREQAIFFAIANAKK GDVVLIAGKGHETYQQIGNETFDFDDAEVAARAIVELNKNKTNS*" gene 1586330..1587814 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" S_feature 1587815..1587925 /Source="Nicolas_S_feature" /locus_tag="new_1587815_1587925" /HighExp="G180, G135, G150, C30, Oxctl, dia0, LBGexp, MG 25, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S558" CDS 1587926..1588900 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" /EC_number="2.7.8.13" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phospho-N-acetylmuramoyl-pentapeptide undecaprenyl phosphate (C55P) transferase" /protein_id="NP_389402.2" /db_xref="EnsemblGenomes-Gn:BSU15190" /db_xref="EnsemblGenomes-Tr:CAB13392" /db_xref="GOA:Q03521" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR003524" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG10224" /db_xref="UniProtKB/Swiss-Prot:Q03521" /translation="MLEQVILFTILMGFLISVLLSPILIPFLRRLKFGQSIREEGPKS HQKKSGTPTMGGVMIILSIIVTTIVMTQKFSEISPEMVLLLFVTLGYGLLGFLDDYIK VVMKRNLGLTSKQKLIGQIIIAVVFYAVYHYYNFATDIRIPGTDLSFDLGWAYFILVL FMLVGGSNAVNLTDGLDGLLSGTAAIAFGAFAILAWNQSQYDVAIFSVAVVGAVLGFL VFNAHPAKVFMGDTGSLALGGAIVTIAILTKLEILLVIIGGVFVIETLSVILQVISFK TTGKRIFKMSPLHHHYELVGWSEWRVVVTFWAAGLLLAVLGIYIEVWL*" gene 1587926..1588900 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" CDS 1588901..1590256 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" /EC_number="6.3.2.9" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1765076, 9218784, 10966819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate ligase" /protein_id="NP_389403.1" /db_xref="EnsemblGenomes-Gn:BSU15200" /db_xref="EnsemblGenomes-Tr:CAB13393" /db_xref="GOA:Q03522" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005762" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10225" /db_xref="UniProtKB/Swiss-Prot:Q03522" /translation="MENDQFLQKQHFLILGLAKSGYAAASILHEKGIYVAVNDQKPFE ENEPAQKLSEKGIEVVCGEHPVSLFDQHQITILIKNPGIPYENIMVQEAEKRGIPVWT EIELAYYLTSAKFIGITGSNGKTTTTTLIYEMLKADSQKALIAGNIGTVASEVAYHAD GDEWIVTELSSFQLMGTHAFRPEISLILNVFDAHLDYHHTRENYEKAKQKVYLHQTAS DKAIVNQDDETVVRLAEAGKAEIVPFSVSKTLEQGAYVKDSMIMFNGEAILPLEEVVL PGAHNLENILAAIAVVKTAGASNEAVKKVLTSFTGVKHRLQYVTTVNGRKFYNDSKAT NILATSKALSAFDKPVILLAGGLDRGNGFDDLKPYMKHVKAVLTFGQTAPKLEKLGNE LGIQHVKRVDNVEQAVSAAFALSNEGDVILLSPACASWDQFKTFEERGDMFIDAVHML K*" gene 1588901..1590256 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" promotor_-35 1590080..1590085 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-35" promotor_-10 1590101..1590119 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-10" upshifts 1590111 /Source="Nicolas_upshifts" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" CDS 1590317..1591417 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:2509435, 9622350, 15849754, 16484183, 16850406, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509435, 9622350, 15849754, 16484183, 16850406, 27312048; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="factor for spore cortex peptidoglycan synthesis (stage V sporulation)" /protein_id="NP_389404.1" /db_xref="EnsemblGenomes-Gn:BSU15210" /db_xref="EnsemblGenomes-Tr:CAB13394" /db_xref="GOA:P07373" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR013437" /db_xref="InterPro:IPR013438" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10226" /db_xref="UniProtKB/Swiss-Prot:P07373" /translation="MTTKKTSPDLLLVIITLLLLTIGLIMVYSASAVWADYKFDDSFF FAKRQLLFAGIGVIAMFFIMNVDYWTWRTWSKLLMVICFFLLVLVLIPGVGMVRNGSR SWIGVGAFSIQPSEFMKLAMIAFLAKFLSEKQKNITSFRRGFVPALGIVFSAFLIIMC QPDLGTGTVMVGTCIVMIFVAGARIAHFVFLGLIGLSGFVGLVLSAPYRIKRITSYLN PWEDPLGSGFQIIQSLYAVGPGGLFGMGLGQSRQKFFYLPEPQTDFIFAILSEELGFI GGTLILLLFSVLLWRGIRIALGAPDLYGSFVAVGIISMIAIQVMINIGVVTGLIPVTG ITLPFLSYGGSSLTLMLMAVGVLLNVSRYSRY*" gene 1590317..1591417 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" S_feature 1591418..1591539 /Source="Nicolas_S_feature" /locus_tag="new_1591418_1591539" /HighExp="G180, C30, G135, G150, Oxctl, Paraq, LBGexp, dia0, S3, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-" /TUshortPSig="0.569, 1, 0.436" /TUlongSig="NA" /TUlongPSig="NA" /label="S559" CDS 1591540..1592631 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" /EC_number="2.4.1.227" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9244290, 11042447, 12538870, 12682299, 12813070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9244290, 11042447, 12538870, 12682299, 12813070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine-N-acetylmuramyl- (pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase" /protein_id="NP_389405.2" /db_xref="EnsemblGenomes-Gn:BSU15220" /db_xref="EnsemblGenomes-Tr:CAB13395" /db_xref="GOA:P37585" /db_xref="InterPro:IPR004276" /db_xref="InterPro:IPR006009" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10227" /db_xref="UniProtKB/Swiss-Prot:P37585" /translation="MRIAISGGGTGGHIYPALAFIKEVQRRHPNVEFLYIGTENGLEK KIVERENIPFRSIEITGFKRKLSFENVKTVMRFLKGVKKSKSYLAEFKPDAVIGTGGY VCGPVVYAAAKMGIPTIVHEQNSLPGITNKFLSKYVNKVAICFEEAKSHFPSEKVVFT GNPRASEVVSIKTGRSLAEFGLSEDKKTVLIFGGSRGAAPINRAVIDMQDVLKTRDYQ VLYITGEVHYEKVMNELKSKGAADNMVTKPFLHQMPEYLKAIDVIVARAGATTIAEIT ALGIPSVLIPSPYVTANHQEVNARSLGQHDAAIVLKETELSGEKLIEALDRIVLNEQT LKEMSERTKSLGVPDAAARLYSVLEELKK*" gene 1591540..1592631 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" promotor_-35 1592020..1592029 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1592042..1592057 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1592047 /Source="Nicolas_upshifts" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" promotor_no_box 1592053..1592153 /Source="Nicolas_upshift_promotors" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1592113 /Source="Nicolas_upshifts" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" CDS 1592663..1593574 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" /EC_number="1.3.1.98" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11327854, 12682299, 16484183, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylenolpyruvoylglucosamine reductase" /protein_id="NP_389406.1" /db_xref="EnsemblGenomes-Gn:BSU15230" /db_xref="EnsemblGenomes-Tr:CAB13396" /db_xref="GOA:P18579" /db_xref="InterPro:IPR003170" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR011601" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036635" /db_xref="SubtiList:BG10228" /db_xref="UniProtKB/Swiss-Prot:P18579" /translation="MEKVIQELKEREVGKVLANEPLANHTTMKIGGPADVLVIPSSVD AVKDIMDVIKKYDVKWTVIGRGSNLLVLDEGIRGVVIKLGAGLDHLELEGEQVTVGGG YSVVRLATSLSKKGLSGLEFAAGIPGSVGGAVYMNAGAHGSDMSEILVKAHILFEDGT IEWLTNEQMDFSYRTSVLQKKRPGVCLEAVLQLEQKDKESIVQQMQSNKDYRKNTQPY SSPCAGSIFRNPLPNHAGNLVEKAGLKGYQIGGAKISEMHGNFIVNAGGASAKDVLDL IDHVKKTIREKYEIDMHTEVEIIGGNR*" gene 1592663..1593574 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" downshifts 1593592 /Source="Nicolas_upshifts" /id="D863" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="5.78428" /MaxDrop="2.8642" /score="-7.67573434" /energy="-7.4" /TU="U1267,U1268,U1269,U1270" /idTUdmin="U1266" /TUdmin=1809 /isTUend="FALSE" CDS 1593704..1594495 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389407.1" /db_xref="EnsemblGenomes-Gn:BSU15240" /db_xref="EnsemblGenomes-Tr:CAB13397" /db_xref="GOA:P16655" /db_xref="InterPro:IPR005548" /db_xref="InterPro:IPR013685" /db_xref="InterPro:IPR026580" /db_xref="InterPro:IPR034746" /db_xref="SubtiList:BG10229" /db_xref="UniProtKB/Swiss-Prot:P16655" /translation="MNPGQDREKIVNIEERIPKIKEQRKQKANRRLISFIMLFFIMVL IIVYLQTPISKVSTISVTGNENVSKKEIIDLSDINSGDTEFWSLDKQKTEKKIQQNKL VKKAEISKSLPNKINIAIEEYKAIAYLEKDDVYYEVLENGSVLPNEVTPDDAGPILVN WTNAKKRSQMAKQLDALSNSLKQSISEIYYTPVKMDENRIKLYMNDGYVVTASIKTFA DRMKTYPSIISQLSSNKKGIIHLEVATYFEEFGKNDKAAKKEDEN*" gene 1593704..1594495 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" CDS 1594492..1595187 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389408.2" /db_xref="EnsemblGenomes-Gn:BSU15250" /db_xref="EnsemblGenomes-Tr:CAB13398" /db_xref="GOA:C0SPA3" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11490" /db_xref="UniProtKB/Swiss-Prot:C0SPA3" /translation="MRGKSAVLLSLIMLIAGFLISFSFQMTKENNKSAAETEEWKKEY ALRDELLKQEKENKKFEKELYQKQNKVRQAENKLKKEKSEYYNVLEDTEKYRMYIGEV GVQGEGVEVTLEDASYIPEGENVNSYIVHESHIFQVVNELYISGAAAVAVNGQRLTHD SYIKCNGPVVTVDGVQHPAPFTVSAIGDPDVLLPSLNIAGGLIDQLSMDHISVSAEKE KNVQMKPILKTKE*" gene 1594492..1595187 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" CDS 1595210..1595917 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183, 18179421" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389409.2" /db_xref="EnsemblGenomes-Gn:BSU15260" /db_xref="EnsemblGenomes-Tr:CAB13399" /db_xref="GOA:Q45544" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11489" /db_xref="UniProtKB/Swiss-Prot:Q45544" /translation="MKIKRSFISISVLMVIFGLMISVQFNSLKHPKVRDTRDMWDIRE ELTSEQKKQEKLLAEINKYDKLLNSYSQTKEMTKETALNNTLQSLKKTAGMTDITGSG IVITISPLFSESLTGEPIENPPPDLLKKLINELNSYGAEHISINERRVVNHTVIRDIN GTTKIDGYALDDYPLTVKVLAKDPDMLHSRVKGSGLEDLFASENLALKAGKSESKLTL KAYDRPLDVQQLKLLKD*" gene 1595210..1595917 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" CDS 1595935..1596300 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1569582, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (small basic protein)" /protein_id="NP_389410.1" /db_xref="EnsemblGenomes-Gn:BSU15270" /db_xref="EnsemblGenomes-Tr:CAB13400" /db_xref="GOA:P28265" /db_xref="InterPro:IPR009709" /db_xref="SubtiList:BG10230" /db_xref="UniProtKB/Swiss-Prot:P28265" /translation="MWLPVLGLVLGIAIGLMTNLTIPSEYSNYLSLAVLAALDTLIGG IRAHLQGTYDEMVFVSGFFFNIILAISLAFLGVHLGVDLYLAGIFAFGVRLFQNIAVI RRNLLTKWTLSKKNKKNVI*" gene 1595935..1596300 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" promotor_-35 1596152..1596155 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1596171..1596190 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1596187 /Source="Nicolas_upshifts" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" S_feature 1596301..1596473 /Source="Nicolas_S_feature" /locus_tag="new_1596301_1596473" /HighExp="T3.0H, T2.30H, S2, T3.30H, Lbtran, T4.0H, T5.0H, T1.30H, S1, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigWXY, SigA" /TUshortPSig="0.989, 0.0739, 1, 1" /TUlongSig="SigEF, Sig-" /TUlongPSig="0.569, 0.436" /label="S560" CDS 1596474..1597796 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein essential for Z-ring assembly" /protein_id="NP_389411.2" /db_xref="EnsemblGenomes-Gn:BSU15280" /db_xref="EnsemblGenomes-Tr:CAB13401" /db_xref="GOA:P28264" /db_xref="InterPro:IPR003494" /db_xref="InterPro:IPR020823" /db_xref="SubtiList:BG10231" /db_xref="UniProtKB/Swiss-Prot:P28264" /translation="MNNNELYVSLDIGTSNTKVIVGEMTDDSLNIIGVGNVPSEGLKK GSIVDIDETVHSIRKAFDQAERMVGFPLRKAIVGVNGNYINIQDTNGVVAVSSENKEI QVEDVRRVMEAAQVVSVPHEQLIVDVIPKQFIVDGRDEITDPKKMLGVRLEVEGTLIT GSKTILHNLLRCVERAGIEITDICLQPLAAGSAALSKDEKNLGVALIDIGGGSTTIAV FQNGHLTSTRVIPLGGENITKDISIGLRTSTEEAERVKKQLGHAYYDEASEDEIFEVT VIGTNQKQTFTQQEAANIIEARVEEILEIVSEELRSMGITDLPGGFVLTGGQAAMPGV MSLAQDVLQNNVRVASPNYIGVRDPQYMTGVGLIQFACRNARIQGRKIGFKMPEEAIQ EIAVSSSEEQEQHHHQNEVQQRPKGKQKTQAEHNKQSKMKKLLSMFWE*" gene 1596474..1597796 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" upshifts complement(1596681) /Source="Nicolas_upshifts" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1596685..1596689) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1596704..1596708) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1597832..1598980 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389412.2" /db_xref="EnsemblGenomes-Gn:BSU15290" /db_xref="EnsemblGenomes-Tr:CAB13402" /db_xref="GOA:P17865" /db_xref="InterPro:IPR000158" /db_xref="InterPro:IPR003008" /db_xref="InterPro:IPR008280" /db_xref="InterPro:IPR018316" /db_xref="InterPro:IPR020805" /db_xref="InterPro:IPR024757" /db_xref="InterPro:IPR036525" /db_xref="InterPro:IPR037103" /db_xref="PDB:2RHH" /db_xref="PDB:2RHJ" /db_xref="PDB:2RHL" /db_xref="PDB:2RHO" /db_xref="PDB:2VAM" /db_xref="PDB:2VXY" /db_xref="PDB:4U39" /db_xref="SubtiList:BG10232" /db_xref="UniProtKB/Swiss-Prot:P17865" /translation="MLEFETNIDGLASIKVIGVGGGGNNAVNRMIENEVQGVEYIAVN TDAQALNLSKAEVKMQIGAKLTRGLGAGANPEVGKKAAEESKEQIEEALKGADMVFVT AGMGGGTGTGAAPVIAQIAKDLGALTVGVVTRPFTFEGRKRQLQAAGGISAMKEAVDT LIVIPNDRILEIVDKNTPMLEAFREADNVLRQGVQGISDLIATPGLINLDFADVKTIM SNKGSALMGIGIATGENRAAEAAKKAISSPLLEAAIDGAQGVLMNITGGTNLSLYEVQ EAADIVASASDQDVNMIFGSVINENLKDEIVVTVIATGFIEQEKDVTKPQRPSLNQSI KTHNQSVPKREPKREEPQQQNTVSRHTSQPADDTLDIPTFLRNRNKRG*" gene 1597832..1598980 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" downshifts 1598954 /Source="Nicolas_upshifts" /id="D864" /incds=0 /nref=226 /ntot=389 /MaxReadThrough="2.85051" /MaxDrop="7.70428" /score="34.7919519" /energy="-13.7" /TU="U1267,U1271" /idTUdmin="U1269" /TUdmin="-5" /isTUend="TRUE" S_feature 1599179..1599282 /Source="Nicolas_S_feature" /locus_tag="new_1599179_1599282" /HighExp="T5.0H, BC, T4.0H, T3.30H, T3.0H, S2, BT, M9-stat, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.953" /TUlongSig="SigA, SigWXY, SigA, Sig-" /TUlongPSig="0.989, 1, 1, 0.436" /label="S561" upshifts 1599179 /Source="Nicolas_upshifts" /id="U1273" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.953046953046953" /xcortree=486 /SigmaFactorBS="tttttatcattttcatatatatggaaattgaatgacatgaaa cgacaatatctgtaattcagATTGTCTACAGTTAATATACagcgatgttctgacaaac c" /listShort="S561, bpr" /GFF_Attribute="listLong" misc_feature 1599181..1599200 /Source="Nicolas_upshift_promotors" /id="U1273" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.953046953046953" /xcortree=486 /SigmaFactorBS="tttttatcattttcatatatatggaaattgaatgacatgaaa cgacaatatctgtaattcagATTGTCTACAGTTAATATACagcgatgttctgacaaac c" /listShort="S561, bpr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1599283..1603584 /gene="bpr" /locus_tag="BSU_15300" /old_locus_tag="BSU15300" /EC_number="3.4.21.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1368833, 1938892, 2106512, 2108961, 15205417, 15375126, 18194340, 18414485, 26497454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1368833, 1938892, 2106512, 2108961, 15205417, 15375126, 18194340, 18414485, 26497454; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillopeptidase F" /protein_id="NP_389413.1" /db_xref="EnsemblGenomes-Gn:BSU15300" /db_xref="EnsemblGenomes-Tr:CAB13403" /db_xref="GOA:P16397" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR008757" /db_xref="InterPro:IPR008969" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR012103" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR033857" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="SubtiList:BG10233" /db_xref="UniProtKB/Swiss-Prot:P16397" /translation="MRKKTKNRLISSVLSTVVISSLLFPGAAGASSKVTSPSVKKELQ SAESIQNKISSSLKKSFKKKEKTTFLIKFKDLANPEKAAKAAVKKAKSKKLSAAKTEY QKRSAVVSSLKVTADESQQDVLKYLNTQKDKGNADQIHSYYVVNGIAVHASKEVMEKV VQFPEVEKVLPNEKRQLFKSSSPFNMKKAQKAIKATDGVEWNVDQIDAPKAWALGYDG TGTVVASIDTGVEWNHPALKEKYRGYNPENPNEPENEMNWYDAVAGEASPYDDLAHGT HVTGTMVGSEPDGTNQIGVAPGAKWIAVKAFSEDGGTDADILEAGEWVLAPKDAEGNP HPEMAPDVVNNSWGGGSGLDEWYRDMVNAWRAADIFPEFSAGNTDLFIPGGPGSIANP ANYPESFATGATDINKKLADFSLQGPSPYDEIKPEISAPGVNIRSSVPGQTYEDGWDG TSMAGPHVSAVAALLKQANASLSVDEMEDILTSTAEPLTDSTFPDSPNNGYGHGLVNA FDAVSAVTDGLGKAEGQVSVEGDDQEPPVYQHEKVTEAYEGGSLPLTLTAEDNVSVTS VKLSYKLDQGEWTEITAKRISGDHLKGTYQAEIPDIKGTKLSYKWMIHDFGGHVVSSD VYDVTVKPSITAGYKQDFETAPGGWVASGTNNNWEWGVPSTGPNTAASGEKVYGTNLT GNYANSANMNLVMPPIKAPDSGSLFLQFKSWHNLEDDFDYGYVFVLPEGEKNWEQAGV YNGKTSSWTDEEIDLSAYKGQNIQVMFNLQSDESIAKEGWYIDDVVLSDKSAGKTVKK NKLGVEKPSGKQKKKPVNPKKAKPSANTAVKHQNKAIQPQVLPLKAQVSVVETGKSTY SDQSTGQYTLKHKAGDYTLMAEAYGYQSKTQKVSLKTDQTTQANFTLEEMKKGTLKGT VINKTTGEPVTGASVYVVEDAAVEPAMTNDKGEYMLEAYEGAYTIKVAAPGYYSDEFS VELKGDVTKETALKPFVGYPGEIAYDDGTAENANSYFAAGNGWAVKMTLADGKDKGML TGGLFRFWDTEFPDPGGTEFKVEVYDATGKDGAPGKKIAGPFNAEALRNGEWTKVDLS SKGIMVDKDFYLVYIQSKPDPYSPGLAMDETGQNSGRNWQYIDGKWQPGDKADGNYMI RALVDYEAAVPEITSPTDKSYTNKDSVTVKGNASPGTTVHIYNGEKEAGETKAAADGT FHAGIILNKGENELTATASTDNGTTDASSPITVTLDQEKPELTLDNPKDGGKTNKETL TVKGAVSDDNLKDVKVNGKKATVADGSYSARILLENGRNEIKVIATDLAGNKTTKKTV IDVNFDKPVISGLIPGEDKNLKAGESVKIAFSSAEDLDATFTIRMPLTNARASVQNAT ELPLREISPGRYEGYWTATSSIKAKGAKVEVIVRDDYGNETRKTANGKLNMNTEN*" gene 1599283..1603584 /gene="bpr" /locus_tag="BSU_15300" /old_locus_tag="BSU15300" downshifts 1603581 /Source="Nicolas_upshifts" /id="D865" /incds=0 /nref=73 /ntot=169 /MaxReadThrough="0.90839" /MaxDrop="8.78054" /score="38.0577497" /energy="-11.4" /TU="NA" /idTUdmin="U1273" /TUdmin=1 /isTUend="TRUE" S_feature complement(1603592..1604734) /Source="Nicolas_S_feature" /locus_tag="new_1603592_1604734_c" /HighExp="S8, S6, S7, S5, LoTm, S4, B36, T5.0H, BT, B60" /AntisenseName="spoIIGA" /AntisenseCor="0.71080549463714104" /AntisenseRegPval="-42" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.579" /TUlongSig="NA" /TUlongPSig="NA" /label="S562" downshifts complement(1603634) /Source="Nicolas_upshifts" /id="D866" /incds=0 /nref=5 /ntot=22 /MaxReadThrough="2.36451" /MaxDrop="3.61596" /score="22.1321546" /energy="-9.6" /TU="NA" /idTUdmin="U1275" /TUdmin=0 /isTUend="TRUE" S_feature 1603712..1603778 /Source="Nicolas_S_feature" /locus_tag="new_1603712_1603778" /HighExp="M9-stat, T5.0H, S4, LoTm, T3.30H, T3.0H, B60, S3, S5, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.534" /TUlongSig="NA" /TUlongPSig="NA" /label="S563" upshifts 1603714 /Source="Nicolas_upshifts" /id="U1274" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.282717282717283" /psig="0.534465534465534" /xcortree=966 /SigmaFactorBS="gcagatttccctgaaaaattgtattttcctctcaacattaat tgacagactttcccacagaGCTTGCTTTATACTTATGAAgcaagaaggggaacagcgt g" /listShort="S563, spoIIGA, sigE, S564, sigG, S565" /listLong="ylmA, NA, thiQ" misc_feature 1603715..1603734 /Source="Nicolas_upshift_promotors" /id="U1274" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.282717282717283" /psig="0.534465534465534" /xcortree=966 /SigmaFactorBS="gcagatttccctgaaaaattgtattttcctctcaacattaat tgacagactttcccacagaGCTTGCTTTATACTTATGAAgcaagaaggggaacagcgt g" /listShort="S563, spoIIGA, sigE, S564, sigG, S565" /listLong="ylmA, NA, thiQ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature complement(1603732..1603744) /Source="Nicolas_upshift_promotors" /id="U1275" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.185814185814186" /xcortree=1053 /SigmaFactorBS="caaatgacatctaaatagattttcacatctgactcctttctt tcttgcctcacgctgttcCCCTTCTTGCTTCataagtataaagcaagctctgtgggaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1603744) /Source="Nicolas_upshifts" /id="U1275" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.185814185814186" /xcortree=1053 /SigmaFactorBS="caaatgacatctaaatagattttcacatctgactcctttctt tcttgcctcacgctgttcCCCTTCTTGCTTCataagtataaagcaagctctgtgggaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1603779..1604708 /gene="spoIIGA" /locus_tag="BSU_15310" /old_locus_tag="BSU15310" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7585939, 7729420, 9573195, 9663680, 10498732, 15849754, 16850406, 18378688, 21362630, 22111992" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7585939, 7729420, 9573195, 9663680, 10498732, 15849754, 16850406, 18378688, 21362630, 22111992; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protease processing pro-sigma-E" /protein_id="NP_389414.1" /db_xref="EnsemblGenomes-Gn:BSU15310" /db_xref="EnsemblGenomes-Tr:CAB13405" /db_xref="GOA:P13801" /db_xref="InterPro:IPR005081" /db_xref="SubtiList:BG10234" /db_xref="UniProtKB/Swiss-Prot:P13801" /translation="MKIYLDVIWLLNFCFDALLLLLTAFILKRHVKKRRLVGGAFIGS SIVLLMFTPFSPIVEHPAGKLAFSVVIVVVTFGFKRFRFFFQNLFSFYFATFLMGGGI IGAHSLLQSNSIVQNGVMITNQTGFGDPISWLFIVGGFPALWFFSKRRIEDIETKNIQ YEERVSVQADLGSQTLHVRGLIDSGNQLYDPLTKTPVMIIYIDKLEPIFGTAETMIIR NTDPLEAIEQLDDSFRFLDKMRLIPYRGVGQQNQFLLCVKPDHVTIMTKEEMISADKC LIGISTTKLSADGEFDAIIHPKMLSGKAVKHVS*" gene 1603779..1604708 /gene="spoIIGA" /locus_tag="BSU_15310" /old_locus_tag="BSU15310" promotor_-10 complement(1604723..1604742) /Source="Nicolas_upshift_promotors" /id="U1276" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.57942057942058" /xcortree=1054 /SigmaFactorBS="gtcaaccgtaatttcagttttttcatcttcctctccCTTCta aatgtcacgccgTTTGAGTATGATAAGTAACGgacatttgcgaacattatgaaacgtg t" /listShort="S562" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1604736) /Source="Nicolas_upshifts" /id="U1276" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.57942057942058" /xcortree=1054 /SigmaFactorBS="gtcaaccgtaatttcagttttttcatcttcctctccCTTCta aatgtcacgccgTTTGAGTATGATAAGTAACGgacatttgcgaacattatgaaacgtg t" /listShort="S562" /GFF_Attribute="listLong" promotor_-35 complement(1604757..1604760) /Source="Nicolas_upshift_promotors" /id="U1276" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.57942057942058" /xcortree=1054 /SigmaFactorBS="gtcaaccgtaatttcagttttttcatcttcctctccCTTCta aatgtcacgccgTTTGAGTATGATAAGTAACGgacatttgcgaacattatgaaacgtg t" /listShort="S562" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1604771..1605490 /gene="sigE" /locus_tag="BSU_15320" /old_locus_tag="BSU15320" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1581961, 7708009, 8464402, 15187183, 20802044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1581961, 7708009, 8464402, 15187183, 20802044; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma-29 factor (sigma-E)" /protein_id="NP_389415.2" /db_xref="EnsemblGenomes-Gn:BSU15320" /db_xref="EnsemblGenomes-Tr:CAB13406" /db_xref="GOA:P06222" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014200" /db_xref="InterPro:IPR014284" /db_xref="SubtiList:BG10235" /db_xref="UniProtKB/Swiss-Prot:P06222" /translation="MKKLKLRLTHLWYKLLMKLGLKSDEVYYIGGSEALPPPLSKDEE QVLLMKLPNGDQAARAILIERNLRLVVYIARKFENTGINIEDLISIGTIGLIKAVNTF NPEKKIKLATYASRCIENEILMYLRRNNKIRSEVSFDEPLNIDWDGNELLLSDVLGTD DDIITKDIEANVDKKLLKKALEQLNEREKQIMELRFGLVGEEEKTQKDVADMMGISQS YISRLEKRIIKRLRKEFNKMV*" gene 1604771..1605490 /gene="sigE" /locus_tag="BSU_15320" /old_locus_tag="BSU15320" S_feature 1605491..1605580 /Source="Nicolas_S_feature" /locus_tag="new_1605491_1605580" /HighExp="T5.0H, S3, M9-stat, T4.0H, S4, LoTm, S2, B60, B36, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.534" /TUlongSig="NA" /TUlongPSig="NA" /label="S564" promotor_-35 1605564..1605570 /Source="Nicolas_upshift_promotors" /id="U1277" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.923076923076923" /psig="0.923076923076923" /xcortree=1135 /SigmaFactorBS="cagggatttcctgatttcgacagtttttcggtctgagtgcag TGCATATttttcccacccaaGGAGATACTTAAcgttgtacagcagctcctgtagggag g" /listShort="sigG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1605582 /Source="Nicolas_upshifts" /id="U1277" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.923076923076923" /psig="0.923076923076923" /xcortree=1135 /SigmaFactorBS="cagggatttcctgatttcgacagtttttcggtctgagtgcag TGCATATttttcccacccaaGGAGATACTTAAcgttgtacagcagctcctgtagggag g" /listShort="sigG" /GFF_Attribute="listLong" promotor_-10 1605584..1605595 /Source="Nicolas_upshift_promotors" /id="U1277" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.923076923076923" /psig="0.923076923076923" /xcortree=1135 /SigmaFactorBS="cagggatttcctgatttcgacagtttttcggtctgagtgcag TGCATATttttcccacccaaGGAGATACTTAAcgttgtacagcagctcctgtagggag g" /listShort="sigG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1605630..1606412 /gene="sigG" /locus_tag="BSU_15330" /old_locus_tag="BSU15330" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15187183, 15256570, 16166546, 16497325, 17015665, 21935351" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187183, 15256570, 16166546, 16497325, 17015665, 21935351; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma factor(sigma-G)" /protein_id="NP_389416.1" /db_xref="EnsemblGenomes-Gn:BSU15330" /db_xref="EnsemblGenomes-Tr:CAB13407" /db_xref="GOA:P19940" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014212" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014322" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10236" /db_xref="UniProtKB/Swiss-Prot:P19940" /translation="MSRNKVEICGVDTSKLPVLKNEEMRKLFRQLQDEGDDSAREKLV NGNLRLVLSVIQRFNNRGEYVDDLFQVGCIGLMKSIDNFDLSHNVKFSTYAVPMIIGE IRRYLRDNNPIRVSRSLRDIAYKALQVRERLISETSKEPTAEDIAKVLEVPHEEIVFA LDAIQDPVSLFEPIYNDGGDPIYVMDQISDERNTDSQWIEELALKEGMRRLNDREKMI LRKRFFQGKTQMEVAEEIGISQAQVSRLEKAAIKQMNKNIHQ*" gene 1605630..1606412 /gene="sigG" /locus_tag="BSU_15330" /old_locus_tag="BSU15330" S_feature 1606413..1606501 /Source="Nicolas_S_feature" /locus_tag="new_1606413_1606501" /HighExp="LoTm, S7, S8, BT, S6, S4, G/S, S3, S2, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.534" /TUlongSig="NA" /TUlongPSig="NA" /label="S565" promotor_-35 1606466..1606473 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1606486..1606505 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1606503 /Source="Nicolas_upshifts" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" CDS 1606560..1607354 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683, 18083814; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389417.2" /db_xref="EnsemblGenomes-Gn:BSU15340" /db_xref="EnsemblGenomes-Tr:CAB13408" /db_xref="GOA:O31723" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13370" /db_xref="UniProtKB/Swiss-Prot:O31723" /translation="MILQLDNVSLKRNGKWILKDIHWKVEEKENWVLYGLNGAGKTAL LNMLCSYYFPTSGEMQVLGHEFGKTELGEKLRRKIGLVSAALQQKLYPADSAFEIALS GAYASIGLYETPSKETREKAIGLLEDLGAIEYADRRYETLSQGEKQRALIARALMADP ELLILDEPVTGLDFIAREKLLDTITYIANKENAPSILYVTHHAEEILPVFDKALLLKQ GEVFGSGEIKEMLTDQILSAFFDTPIHVLWNQDRPFLTRAEPITNA*" gene 1606560..1607354 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" promotor_-35 1607272..1607275 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-35" promotor_-10 1607290..1607309 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-10" upshifts 1607298 /Source="Nicolas_upshifts" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" misc_RNA 1607367..1607468 /gene="tswE" /locus_tag="BSU_misc_RNA_24" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" gene 1607367..1607468 /gene="tswE" /locus_tag="BSU_misc_RNA_24" downshifts 1607455 /Source="Nicolas_upshifts" /id="D867" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="5.58534" /MaxDrop="4.3688" /score="-2.39598083" /energy="-7.1" /TU="U1278,U1279" /idTUdmin="U1274" /TUdmin=971 /isTUend="FALSE" CDS 1607556..1608836 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" /EC_number="3.5.1.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17618314" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17618314; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-4-amino-5-aminomethyl-2- methylpyrimidinedeformylase" /protein_id="NP_389418.2" /db_xref="EnsemblGenomes-Gn:BSU15350" /db_xref="EnsemblGenomes-Tr:CAB13409" /db_xref="GOA:O31724" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13371" /db_xref="UniProtKB/Swiss-Prot:O31724" /translation="MDQQIYSLQKKVEEHKEELIQLAKTLISYQTPAPPARNTEGIQS WIAGYLNELGFSIDKWDVYPGDPNVVGKLKGTDSADYYSLIINGHVDVAEVKEDEEWK HDPFHPIEKNGLLIGRGASDMKGGMACVLFAVKLIREASIELPGDLILQSVIGEEVGE AGTLECCKRGYHADFAIVADTSDMHIQGQGGVITGWIEIKSSQTFHDGTRRNMIHAGG GTFGASAIEKMAKIIAGLGELERHWSIMKSYPGFKPGTNTINPAVIEGGRHAAFIADE CRLWITVHFYPNETHDQVAAEIEDYVNRLSDSDIWLRENRPVFKWGGSSMIEDRGEIF PALEVDPGHPGVLALTASHQKVKRECPIIDVSQSVTDGGWLYDAGIPCVIYGPGDLHN AHSVNEKVSIEQLVEYTKIILDFIISWCSRKKEQ*" gene 1607556..1608836 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" misc_feature complement(1608777..1608793) /Source="Nicolas_upshift_promotors" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1608782) /Source="Nicolas_upshifts" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 1608857..1608862 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-35" promotor_-10 1608878..1608896 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-10" upshifts 1608882 /Source="Nicolas_upshifts" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" CDS 1608919..1609164 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" /experiment="publication(s) with functional evidences, PMID:12429060, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12429060, 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="essential sporulation protein" /protein_id="NP_389419.1" /db_xref="EnsemblGenomes-Gn:BSU15360" /db_xref="EnsemblGenomes-Tr:CAB13410" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13372" /db_xref="UniProtKB/Swiss-Prot:O31725" /translation="MISISEFQVKDVVNVSNGKKLGSIGDIDINVTTGKIQAIILGGN GKVLGFFGKEEELVIPWRNIVKIGEDVILVRLSEPHA*" gene 1608919..1609164 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" promotor_-35 1609080..1609088 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1609099..1609117 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1609107 /Source="Nicolas_upshifts" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" S_feature 1609165..1609275 /Source="Nicolas_S_feature" /locus_tag="new_1609165_1609275" /HighExp="T3.0H, S2, S1, T4.0H, T3.30H, T5.0H, T2.0H, BC, Gly, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34150000000000003" /TUshortSig="SigH, SigEF, SigA, SigA" /TUshortPSig="1, 0.998, 0.976, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S566" misc_feature 1609267..1609286 /Source="Nicolas_upshift_promotors" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1609277 /Source="Nicolas_upshifts" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" CDS 1609327..1610163 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16498617, 19737354; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved protein with laccase domain" /protein_id="NP_389420.1" /db_xref="EnsemblGenomes-Gn:BSU15370" /db_xref="EnsemblGenomes-Tr:CAB13411" /db_xref="GOA:O31726" /db_xref="InterPro:IPR003730" /db_xref="InterPro:IPR011324" /db_xref="SubtiList:BG13373" /db_xref="UniProtKB/Swiss-Prot:O31726" /translation="MNTYHPFSLTTPSTLMIQDWAQTNQNNKEVIAGFTTKNGGVSQK PFESLNTGLHVHDKDADVVKNREYIADMFNTDLQSWVFADQTHDNRVQKVTQRDRGKG AREYHTALKATDGIYTNEKNVFLALCFADCVPLFFYDPVKSLVGVAHAGWKGTVKQIG REMVKQWTEKEGSNPSDIYAVIGPSISGACYTVDDRVMDAVRALPVSADLAANQTAKA QYQLDLKELNRLILMDSGLASEQISVSGLCTESEPSLFYSHRRDQGKTGRMMSFIGMK EA*" gene 1609327..1610163 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" CDS 1610170..1610862 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14526035, 24097949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PLP-containing enzyme" /protein_id="NP_389421.1" /db_xref="EnsemblGenomes-Gn:BSU15380" /db_xref="EnsemblGenomes-Tr:CAB13412" /db_xref="GOA:O31727" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR011078" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG13374" /db_xref="UniProtKB/Swiss-Prot:O31727" /translation="MRVVDNLRHINERINEACNRSGRSSDEVTVIAVTKYVSPERAQE AVDAGITCLGENRDAELLRKQELMKGNPEWHFIGSLQSRKAKSVVNSVSYIHSLDRLS LAKEIEKRAEGTVRCFVQVNTSLEPSKHGMKKEEVIPFIQELSGFEHILVAGLMTMAP LTDDQDQIRSCFRSLRELRDQVQKLNQPNAPCTELSMGMSNDFEIAIEEGATYIRIGS SLVGNETGGVQQ*" gene 1610170..1610862 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" CDS 1610859..1611314 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14526035, 16420366, 16796675, 18782755, 22912848, 24218584" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526035, 16420366, 16796675, 18782755, 22912848, 24218584; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division machinery factor" /protein_id="NP_389422.3" /db_xref="EnsemblGenomes-Gn:BSU15390" /db_xref="EnsemblGenomes-Tr:CAB13413" /db_xref="GOA:O31728" /db_xref="InterPro:IPR007561" /db_xref="InterPro:IPR023052" /db_xref="PDB:3ZIH" /db_xref="PDB:3ZII" /db_xref="SubtiList:BG13375" /db_xref="UniProtKB/Swiss-Prot:O31728" /translation="MSMKNKLKNFFSMEDEEYEYEYIETERESHEEHEQKEKPAYNGN KPAGKQNVVSLQSVQKSSKVVLSEPRVYAEAQEIADHLKNRRAVVVNLQRIQHDQAKR IVDFLSGTVYAIGGDIQRIGSDIFLCTPDNVDVSGTISELISEDEHQRW*" gene 1610859..1611314 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" CDS 1611321..1611593 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14526035, 19966467, 20359373; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, distribution of nucleoids and osmotic tolerance" /protein_id="NP_389423.1" /db_xref="EnsemblGenomes-Gn:BSU15400" /db_xref="EnsemblGenomes-Tr:CAB13414" /db_xref="GOA:O31729" /db_xref="InterPro:IPR003425" /db_xref="SubtiList:BG13376" /db_xref="UniProtKB/Swiss-Prot:O31729" /translation="MILYQVFSVLSLLITIYSFALIIYIFMSWVPSTRETAVGRFLAS ICEPYLEPFRKIIPPIAMLDISPIVAILVLRFATTGLWGLYRMIAF*" gene 1611321..1611593 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" downshifts 1611582 /Source="Nicolas_upshifts" /id="D868" /incds=0 /nref=16 /ntot=97 /MaxReadThrough="6.19839" /MaxDrop="4.93537" /score="-6.17078585" /energy="-15.2" /TU="U1278,U1281,U1282,U1283" /idTUdmin="U1281" /TUdmin="-1452" /isTUend="FALSE" CDS 1611654..1612427 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10093218, 14526035, 21141807; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, RNA-binding fold" /protein_id="NP_389424.1" /db_xref="EnsemblGenomes-Gn:BSU15410" /db_xref="EnsemblGenomes-Tr:CAB13415" /db_xref="GOA:P71020" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11856" /db_xref="UniProtKB/Swiss-Prot:P71020" /translation="MSDIYQHFRKDERAFIDQALEWKRIVQEQYRMKLTDFLDPREQV ILSAVTGQADVGLAFSGGYDRAERKRAILFPEYITPEESDFELQAFNVRYADKFVSVD HRSLLGALMGIGLKRQKFGDIVFSETAVQLIVSADTADFVAAQLTQAGKAAVSLEKID LSDLNIPAVDVEIRDDTVSSLRLDAVCASMSRQSRQKSQTLVKNGLVKVNWKVVEDPS YIVAEGDMLSIRGFGRCSLTKIEGKTKKDKWRVTFERQK*" gene 1611654..1612427 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" promotor_-35 1612143..1612150 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1612164..1612182 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1612187 /Source="Nicolas_upshifts" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" S_feature 1612428..1612520 /Source="Nicolas_S_feature" /locus_tag="new_1612428_1612520" /HighExp="C90, M0t90, C30, GM-0.1, Glucon, MG 5, GM 45, GM 5, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigH, SigEF, SigA" /TUshortPSig="0.973, 1, 1, 0.998, 0.989" /TUlongSig="SigA" /TUlongPSig="0.976" /label="S567" CDS 1612521..1613015 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389425.1" /db_xref="EnsemblGenomes-Gn:BSU15420" /db_xref="EnsemblGenomes-Tr:CAB13416" /db_xref="GOA:P71021" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR019933" /db_xref="PDB:2WUJ" /db_xref="PDB:2WUK" /db_xref="SubtiList:BG11835" /db_xref="UniProtKB/Swiss-Prot:P71021" /translation="MPLTPNDIHNKTFTKSFRGYDEDEVNEFLAQVRKDYEIVLRKKT ELEAKVNELDERIGHFANIEETLNKSILVAQEAAEDVKRNSQKEAKLIVREAEKNADR IINESLSKSRKIAMEIEELKKQSKVFRTRFQMLIEAQLDLLKNDDWDHLLEYEVDAVF EEKE*" gene 1612521..1613015 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" promotor_-35 1613028..1613035 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1613049..1613068 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1613056 /Source="Nicolas_upshifts" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" misc_RNA 1613078..1613304 /gene="iswA" /locus_tag="BSU_misc_RNA_25" /product="T-box riboswitch specific of isoleucine tRNA" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" gene 1613078..1613304 /gene="iswA" /locus_tag="BSU_misc_RNA_25" downshifts 1613271 /Source="Nicolas_upshifts" /id="D869" /incds=0 /nref=43 /ntot=100 /MaxReadThrough="7.76706" /MaxDrop="5.97038" /score="48.8352635" /energy="-19.4" /TU="U1278,U1282,U1283,U1284,U1285" /idTUdmin="U1281" /TUdmin=237 /isTUend="FALSE" CDS 1613357..1616122 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" /EC_number="6.1.1.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16697013, 17043414, 17095543, 28139725; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucyl-tRNA synthetase" /protein_id="NP_389426.2" /db_xref="EnsemblGenomes-Gn:BSU15430" /db_xref="EnsemblGenomes-Tr:CAB13417" /db_xref="GOA:Q45477" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002301" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023585" /db_xref="InterPro:IPR033708" /db_xref="SubtiList:BG11792" /db_xref="UniProtKB/Swiss-Prot:Q45477" /translation="MDFKDTLLMPKTDFPMRGNLPNREPDIQKKWEEEDIYRLVQERT KDRPKFVLHDGPPYANGDIHMGHALNKILKDFIVRYKSMSGYNAPYVPGWDTHGLPIE TALTKNKKVNRKEMSVAEFRKLCEEYAWKQIEGQREQFKRLGVRGDWENPYVTLKPEY EAQQIRVFGEMAKRGYIYKGLKPVNWSPSSESALAEAEIEYQDKRSASIYVAFGVKDG KGVLENGERIIIWTTTPWTIPANLGISVHPDLEYSVIAVGEDRFVVASALVENVASAC GFDQYEVTRTVKGKDLENIIAEHPLYGRDSLVMLGEHVTTDAGTGCVHTAPGHGEDDF IIGQKYGLDVLCPVDEKGVMTSEAPGFEGMFYDDANKAITQQLDEKGALVKLEFITHS YPHDWRTKKPTIFRATAQWFASIKDFRSDLLDAIKETKWVPEWGEQRLHNMVRDRGDW CISRQRAWGVPIPVFYAENGEPVITDETIEHVSELFRQHGSNIWFEKEAKDLLPEGFT HPGSPNGTFTKEQDIMDVWFDSGSSHQAVLEERDDLVRPADLYLEGSDQYRGWFNSSL STAVAVTGKAPYKGVLSHGFALDGEGRKMSKSIGNVVVPAKVMKQLGADILRLWVSSV DYQADVRVSDAILKQVAEVYRKIRNTFRFLHGNLFDFDPKTNAVAVEDLREVDQYMLI KLNKLIDKVKKAYDEYEFAVVYHSIHNFCTIELSSFYLDFAKDIVYIEHADHPDRRSM QTVFYETLLALVKLSAPILPHTADELWSHLTFVEEQSVQLTDMPETITVPNSEATEEK FDRFMALRDDVLKALETARNEKIIGKSLEANLKLYPNKENKELLASIKENLSQLFIVS ELTISEENEAPNDAQSFATGKIAVEKAEGEMCERSRVISKDVGANPKYPTLSLRNAEI VEKYYQK*" gene 1613357..1616122 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" downshifts 1616113 /Source="Nicolas_upshifts" /id="D870" /incds=0 /nref=233 /ntot=261 /MaxReadThrough="2.6695" /MaxDrop="6.91924" /score="40.2175565" /energy="-13.9" /TU="NA" /idTUdmin="U1278" /TUdmin="-1" /isTUend="TRUE" downshifts complement(1616168) /Source="Nicolas_upshifts" /id="D871" /incds=0 /nref=6 /ntot=17 /MaxReadThrough="1.29709" /MaxDrop="3.66645" /score="13.8608728" /energy="-15.6" /TU="NA" /idTUdmin="U1275" /TUdmin="-12534" /isTUend="FALSE" promotor_-35 1616203..1616209 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-35" promotor_-10 1616224..1616235 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-10" upshifts 1616224 /Source="Nicolas_upshifts" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" CDS 1616267..1616641 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15496987, 23123912, 23678950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15496987, 23123912, 23678950; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related RNA polymerase-binding factor" /protein_id="NP_389427.2" /db_xref="EnsemblGenomes-Gn:BSU15440" /db_xref="EnsemblGenomes-Tr:CAB13418" /db_xref="GOA:Q45478" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR016841" /db_xref="InterPro:IPR020458" /db_xref="SubtiList:BG11795" /db_xref="UniProtKB/Swiss-Prot:Q45478" /translation="MNDQLTAIYTELLLMKEELQSRLFEYSCFQVSTSPQAAINQKQK ATLIYHIKEELQDVLLALSKIENGTFGYCEETGAPIPLAKLAVLPTARTANDFLYSVQ FEKKTLPIWKSTDIEYGQALYE*" gene 1616267..1616641 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" promotor_-35 1616673..1616677 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" upshifts 1616692 /Source="Nicolas_upshifts" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" promotor_-10 1616693..1616712 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" CDS 1616744..1617208 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" /EC_number="3.4.23.36" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9880550, 9882689, 10497172, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880550, 9882689, 10497172, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="signal peptidase II" /protein_id="NP_389428.1" /db_xref="EnsemblGenomes-Gn:BSU15450" /db_xref="EnsemblGenomes-Tr:CAB13419" /db_xref="GOA:Q45479" /db_xref="InterPro:IPR001872" /db_xref="SubtiList:BG11793" /db_xref="UniProtKB/Swiss-Prot:Q45479" /translation="MLYYMIALLIIAADQLTKWLVVKNMELGQSIPIIDQVFYITSHR NTGAAWGILAGQMWFFYLITTAVIIGIVYYIQRYTKGQRLLGVALGLMLGGAIGNFID RAVRQEVVDFIHVIIVNYNYPIFNIADSSLCVGVMLLFIQMLLDSGKKKKEQ*" gene 1616744..1617208 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" CDS 1617210..1618121 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15078091, 15928344, 17188032, 17937767, 18032607, 20817755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389429.3" /db_xref="EnsemblGenomes-Gn:BSU15460" /db_xref="EnsemblGenomes-Tr:CAB13420" /db_xref="GOA:Q45480" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11796" /db_xref="UniProtKB/Swiss-Prot:Q45480" /translation="MNQIDITASEEQKSERIDKFLASTENDWSRTQVQQWVKDGQVVV NGSAVKANYKIQPGDQVTVTVPEPEALDVLAEPMDLDIYYEDQDVLVVNKPRGMVVHP APGHLTGTLVNGLMAHCTDLSGINGVMRPGIVHRIDKDTSGLLMVAKNDMAHESLVNQ LVNKTVTRKYTAVVHGLISHDDGTIDAPIGRDKKDRQSMTVTRDGKNAVTHFHVLERF QDFTLVECQLETGRTHQIRVHMKYIGFPLAGDPKYGPRKTIDFNGQALHAGVLGFDHP RTGEYVEFEAPLPEDMAELIENLRKNG*" gene 1617210..1618121 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" promotor_-35 1618116..1618123 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" promotor_-10 1618138..1618157 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" upshifts 1618152 /Source="Nicolas_upshifts" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" misc_RNA 1618161..1618277 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" gene 1618161..1618277 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" CDS 1618304..1618849 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" /EC_number="2.4.2.9" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7798145, 9932459, 12482852, 15716449, 17322189, 18678934" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 9932459, 12482852, 15716449, 17322189, 18678934; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional attenuator and uracil phosphoribosyltransferase activity" /protein_id="NP_389430.1" /db_xref="EnsemblGenomes-Gn:BSU15470" /db_xref="EnsemblGenomes-Tr:CAB13421" /db_xref="GOA:P39765" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR023050" /db_xref="InterPro:IPR029057" /db_xref="PDB:1A3C" /db_xref="PDB:1A4X" /db_xref="PDB:4P82" /db_xref="SubtiList:BG10712" /db_xref="UniProtKB/Swiss-Prot:P39765" /translation="MNQKAVILDEQAIRRALTRIAHEMIERNKGMNNCILVGIKTRGI YLAKRLAERIEQIEGNPVTVGEIDITLYRDDLSKKTSNDEPLVKGADIPVDITDQKVI LVDDVLYTGRTVRAGMDALVDVGRPSSIQLAVLVDRGHRELPIRADYIGKNIPTSKSE KVMVQLDEVDQNDLVAIYENE*" gene 1618304..1618849 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" downshifts complement(1618498) /Source="Nicolas_upshifts" /id="D872" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="1.85132" /MaxDrop="2.50006" /score="0.812637138" /energy="-7" /TU="NA" /idTUdmin="U1275" /TUdmin="-14864" /isTUend="FALSE" downshifts 1618840 /Source="Nicolas_upshifts" /id="D873" /incds=0 /nref=13 /ntot=149 /MaxReadThrough="8.16191" /MaxDrop="3.4492" /score="16.3570883" /energy="-11.5" /TU="U1287,U1288" /idTUdmin="U1286" /TUdmin=704 /isTUend="FALSE" misc_RNA 1618853..1618970 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" gene 1618853..1618970 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" CDS 1619023..1620330 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8206848, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uracil permease" /protein_id="NP_389431.2" /db_xref="EnsemblGenomes-Gn:BSU15480" /db_xref="EnsemblGenomes-Tr:CAB13422" /db_xref="GOA:P39766" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR029935" /db_xref="SubtiList:BG10992" /db_xref="UniProtKB/Swiss-Prot:P39766" /translation="MSKKKVNLGVRDVPTPFSWVSFSLQHLFAMFGSTILVPKLVGMS PAVALVTSGIGTLAYLLITKGQIPAYLGSSFAFISPIILVKATGGPGAAMVGAFLAGL VYGLIALLIRQLGTGWLMKILPPVVVGPVIIVIGLGLASTAVNMAMYADPNASELVYS LKHFSVAGVTLAITIICAIFLRGFLSLIPVLIGIIGGYLFALTQGIVNFQPVLDAKWF AVPEFIIPFKDYSPSVTLGIAAAMVPVAFVTMSEHIGHQMVLSKVVGQDFIKKPGLHR SIMGDSVATILASLIGGPPTTTYGENIGVLAITRVFSVFVIGGAAVIALCFGFIGKIS ALISSVPSAVMGGVSFLLFGIIASSGLRMLIDNKIDYENNRNLIITSVILVIGVGGAF IQVSQGGFQVSGMALAAIVGVILNLILPQAKEEQADTSEQHHI*" gene 1619023..1620330 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" misc_RNA 1620331..1620445 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" gene 1620331..1620445 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" CDS 1620476..1621390 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" /EC_number="2.1.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8535162, 16321950, 21663747" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8535162, 16321950, 21663747; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate carbamoyltransferase" /protein_id="NP_389432.2" /db_xref="EnsemblGenomes-Gn:BSU15490" /db_xref="EnsemblGenomes-Tr:CAB13423" /db_xref="GOA:P05654" /db_xref="InterPro:IPR002082" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR036901" /db_xref="PDB:2AT2" /db_xref="PDB:3R7D" /db_xref="PDB:3R7F" /db_xref="PDB:3R7L" /db_xref="SubtiList:BG10713" /db_xref="UniProtKB/Swiss-Prot:P05654" /translation="MKHLTTMSELSTEEIKDLLQTAQELKSGKTDNQLTGKFAANLFF EPSTRTRFSFEVAEKKLGMNVLNLDGTSTSVQKGETLYDTIRTLESIGVDVCVIRHSE DEYYEELVSQVNIPILNAGDGCGQHPTQSLLDLMTIYEEFNTFKGLTVSIHGDIKHSR VARSNAEVLTRLGARVLFSGPSEWQDEENTFGTYVSMDEAVESSDVVMLLRIQNERHQ SAVSQEGYLNKYGLTVERAERMKRHAIIMHPAPVNRGVEIDDSLVESEKSRIFKQMKN GVFIRMAVIQRALQTNVKRGEAAYVISH*" gene 1620476..1621390 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" CDS 1621374..1622660 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" /EC_number="3.5.2.3" /function="2: Purines, pyrimidines, nucleosides, and nucleotides" /experiment="publication(s) with functional evidences, PMID:7516791, 16522191, 21045288" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7516791, 16522191, 21045288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotase" /protein_id="NP_389433.2" /db_xref="EnsemblGenomes-Gn:BSU15500" /db_xref="EnsemblGenomes-Tr:CAB13424" /db_xref="GOA:P25995" /db_xref="InterPro:IPR002195" /db_xref="InterPro:IPR004722" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10714" /db_xref="UniProtKB/Swiss-Prot:P25995" /translation="MSYLIKNGWILNENGEKTQADIRVTGETITAIGKLDATDNETVI DAKGLLVSPGFVDLHVHFREPGGEKKETIETGAKAAARGGYTTVAAMPNTRPVPDTKE QMEWVQNRIKETSCVRVLPYASITIRQIGDEMTNFEALKEAGAFAFTDDGVGIQTAGM MYEAMKRAAAIDKAIVAHCEDNSLIYGGSVHEGTFSKANGLNGIPSVCESVHIARDVL LAEAANCHYHVCHISTKESVRVVRDAKKAGIRVTAEVSPHHLLLCDEDIPGLDTNYKM NPPLRSPEDRAALIEGLLDGTIDFIATDHAPHTEEEKNTEMKLAPFGIVGLETAFPLL YTHFVKNGSWSLKQLIDYMTIKPCEAFGLPYGTLQTGQAADITLIDLEKEAVIDKETF LSKGKNTPFNGISCTGWPVATIAAGKLAYEEGRLVK*" gene 1621374..1622660 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" CDS 1622657..1623751 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1709162, 11390694, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (small subunit, glutaminase subunit)" /protein_id="NP_389434.1" /db_xref="EnsemblGenomes-Gn:BSU15510" /db_xref="EnsemblGenomes-Tr:CAB13425" /db_xref="GOA:P25993" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10715" /db_xref="UniProtKB/Swiss-Prot:P25993" /translation="MKRRLVLENGAVFEGEAFGSLEHNMGEVVFNTGMTGYQEILSDP SYCGQIVTLTYPLIGNYGINRDDFESITPFVKGLIIKELCELPSNWRSAYTLDEYLKM KNIPGLQGIDTRKLTRMIRTAGALKGTFASSDEDIEAVLKRLNETELPRNQVSQVSAK TAYPSPGRGKRIVLVDFGMKHGILRELNKRKCDVIVVPYNITAEEVLQLKPDGIMLSN GPGDPKDVPEAIEMIKGVLGKVPLFGICLGHQLFALACGANTEKMKFGHRGSNHPVKE LATGKVALTSQNHGYTVSSISKTELEVTHIAINDDTIEGLKHKTLPAFTVQYHPEASP GPEDANHLFDRFIEMIETTEKEGEAVCQNA*" gene 1622657..1623751 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" CDS 1623736..1626951 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 216664, 6120161, 10732707, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (large subunit)" /protein_id="NP_389435.1" /db_xref="EnsemblGenomes-Gn:BSU15520" /db_xref="EnsemblGenomes-Tr:CAB13426" /db_xref="GOA:P25994" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR033937" /db_xref="InterPro:IPR036897" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10716" /db_xref="UniProtKB/Swiss-Prot:P25994" /translation="MPKRVDINKILVIGSGPIIIGQAAEFDYAGTQACLALKEEGYEV ILVNSNPATIMTDTEMADRVYIEPLTPEFLTRIIRKERPDAILPTLGGQTGLNLAVEL SERGVLAECGVEVLGTKLSAIQQAEDRDLFRTLMNELNEPVPESEIIHSLEEAEKFVS QIGFPVIVRPAYTLGGTGGGICSNETELKEIVENGLKLSPVHQCLLEKSIAGYKEIEY EVMRDSQDHAIVVCNMENIDPVGIHTGDSIVVAPSQTLSDREYQLLRNVSLKLIRALG IEGGCNVQLALDPDSFQYYIIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLSLDEM MNPVTGKTYAAFEPALDYVVSKIPRWPFDKFESANRKLGTQMKATGEVMAIGRTLEES LLKAVRSLEADVYHLELKDAADISDELLEKRIKKAGDERLFYLAEAYRRGYTVEDLHE FSAIDVFFLHKLFGIVQFEKELKANAGDTDVLRRAKELGFSDQYISREWKMKESELYS LRKQAGIAPVFKMVDTCAAEFESETPYFYSTYEEENESVVTDKKSVMVLGSGPIRIGQ GVEFDYATVHSVWAIKQAGYEAIIVNNNPETVSTDFSISDKLYFEPLTIEDVMHIIDL EQPMGVVVQFGGQTAINLADELSARGVKILGTSLEDLDRAEDRDKFEQALGELGVPQP LGKTATSVNQAVSIASDIGYPVLVRPSYVLGGRAMEIVYHEEELLHYMKNAVKINPQH PVLIDRYLTGKEIEVDAVSDGETVVIPGIMEHIERAGVHSGDSIAVYPPQSLTEDIKK KIEQYTIALAKGLNIVGLLNIQFVLSQGEVYVLEVNPRSSRTVPFLSKITGIPMANLA TKIILGQKLAAFGYTEGLQPEQQGVFVKAPVFSFAKLRRVDITLGPEMKSTGEVMGKD STLEKALYKALIASGIQIPNYGSVLLTVADKDKEEGLAIAKRFHAIGYNILATEGTAG YLKEASIPAKVVGKIGQDGPNLLDVIRNGEAQFVINTLTKGKQPARDGFRIRRESVEN GVACLTSLDTAEAILRVLESMTFRADQMPAVNTNQEAAVTI*" gene 1623736..1626951 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" CDS 1626948..1627718 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" /EC_number="1.3.98.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:169225, 10545205, 11188687, 15299876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 169225, 10545205, 11188687, 15299876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (electron transfer subunit)" /protein_id="NP_389436.1" /db_xref="EnsemblGenomes-Gn:BSU15530" /db_xref="EnsemblGenomes-Tr:CAB13427" /db_xref="GOA:P25983" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR012165" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR019480" /db_xref="InterPro:IPR023455" /db_xref="InterPro:IPR037117" /db_xref="SubtiList:BG10717" /db_xref="UniProtKB/Swiss-Prot:P25983" /translation="MKKAYLTVCSNQQIADRVFQMVLKGELVQGFTTPGQFLHLKVSE AVTPLLRRPISIADVNFEKNEVTIIYRVDGEGTRLLSLKQQGELVDVLGPLGNGFPVN EVQPGKTALLVGGGVGVPPLQELSKRLIEKGVNVIHVLGFQSAKDVFYEEECRQYGDT YVATADGSYGETGFVTDVIKRKKLEFDILLSCGPTPMLKALKQEYAHKEVYLSMEERM GCGIGACFACVCHTNESETSYVKVCLDGPVFKAQEVAL*" gene 1626948..1627718 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" CDS 1627718..1628653 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" /EC_number="1.3.1.15" /experiment="publication(s) with functional evidences, PMID:4380263, 10545205" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4380263, 10545205; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (catalytic subunit)" /protein_id="NP_389437.1" /db_xref="EnsemblGenomes-Gn:BSU15540" /db_xref="EnsemblGenomes-Tr:CAB13428" /db_xref="GOA:P25996" /db_xref="InterPro:IPR001295" /db_xref="InterPro:IPR005720" /db_xref="InterPro:IPR012135" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024920" /db_xref="InterPro:IPR033888" /db_xref="SubtiList:BG10718" /db_xref="UniProtKB/Swiss-Prot:P25996" /translation="MLEVKLPGLDLKNPIIPASGCFGFGKEFSRFYDLSCLGAIMIKA TTKEPRFGNPTPRVAETGAGMLNAIGLQNPGLDSVLHHELPWLEQFDTPIIANVAGSQ VDDYVEVAEHISKAPNVHALELNISCPNVKTGGIAFGTNPEMAADLTKAVKEVSDVPV YVKLSPNVANITEIALAIEEAGADGLTMINTLIGMRLDLKTGKPILANKTGGLSGPAV KPVAIRMVYEVSQMVNIPIIGMGGVQTAEDALEFLLAGASAVAVGTANFVNPFACPEI IEQLPSVLLQYGYQSIEECIGRSWNHEKQPAHHRA*" gene 1627718..1628653 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" CDS 1628622..1629341 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" /EC_number="4.1.1.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10681442, 11390694, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10681442, 11390694, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotidine 5'-phosphate decarboxylase" /protein_id="NP_389438.1" /db_xref="EnsemblGenomes-Gn:BSU15550" /db_xref="EnsemblGenomes-Tr:CAB13429" /db_xref="GOA:P25971" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014732" /db_xref="InterPro:IPR018089" /db_xref="PDB:1DBT" /db_xref="SubtiList:BG10719" /db_xref="UniProtKB/Swiss-Prot:P25971" /translation="MKNNLPIIALDFASAEETLAFLAPFQQEPLFVKVGMELFYQEGP SIVKQLKERNCELFLDLKLHDIPTTVNKAMKRLASLGVDLVNVHAAGGKKMMQAALEG LEEGTPAGKKRPSLIAVTQLTSTSEQIMKDELLIEKSLIDTVVHYSKQAEESGLDGVV CSVHEAKAIYQAVSPSFLTVTPGIRMSEDAANDQVRVATPAIAREKGSSAIVVGRSIT KAEDPVKAYKAVRLEWEGIKS*" gene 1628622..1629341 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" CDS 1629320..1629970 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" /EC_number="2.4.2.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9305779, 22447609, 23405251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotate phosphoribosyltransferase" /protein_id="NP_389439.1" /db_xref="EnsemblGenomes-Gn:BSU15560" /db_xref="EnsemblGenomes-Tr:CAB13430" /db_xref="GOA:P25972" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR004467" /db_xref="InterPro:IPR023031" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10720" /db_xref="UniProtKB/Swiss-Prot:P25972" /translation="MGGNQILKQIIAKHLLDIQAVFLRPNEPFTWASGILSPIYCDNR LTLSFPEVRNDVASGISKLVKEHFPEAEMIAGTATAGIPHAALAADHLNLPMCYVRSK PKAHGKGNQIEGAVQEGQKTVVIEDLISTGGSVLEACAALQAAGCEVLGVVSIFTYGL PKAEEAFAKAELPYYSLTDYDTLTEVALENGNIHSDDLKKLQTWKRNPESKDWFKK*" gene 1629320..1629970 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" downshifts 1629972 /Source="Nicolas_upshifts" /id="D874" /incds=0 /nref=17 /ntot=184 /MaxReadThrough="3.91018" /MaxDrop="5.49939" /score="33.4515727" /energy="-9" /TU="U1287,U1288" /idTUdmin="U1287" /TUdmin="-115" /isTUend="FALSE" S_feature 1630017..1630089 /Source="Nicolas_S_feature" /locus_tag="new_1630017_1630089" /HighExp="Cold, Gly, MG 5, S0, LPh, M/G, GM 60, MG t5, Mal, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S568" promotor_-35 1630069..1630076 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1630090..1630109 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1630091 /Source="Nicolas_upshifts" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" misc_RNA 1630115..1630220 /gene="mswE" /locus_tag="BSU_misc_RNA_29" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" gene 1630115..1630220 /gene="mswE" /locus_tag="BSU_misc_RNA_29" S_feature 1630221..1630381 /Source="Nicolas_S_feature" /locus_tag="new_1630221_1630381" /HighExp="MG 10, B60, MG 5, MG t5, M9-exp, MG 25, MG 60, MG 15, GM 90, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S569" CDS 1630382..1631083 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10094622, 11004190, 12072441, 16267287, 18456801" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 11004190, 12072441, 16267287, 18456801; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(phospho)adenosine phosphosulfate reductase" /protein_id="NP_389440.1" /db_xref="EnsemblGenomes-Gn:BSU15570" /db_xref="EnsemblGenomes-Tr:CAB13431" /db_xref="GOA:P94498" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11930" /db_xref="UniProtKB/Swiss-Prot:P94498" /translation="MLTYDNWEEPTITFPEDDPYKGALSVLKWAYGHYGDQLVYACSF GIEGIVLIDLIYKVKKDAEIVFLDTGLHFKETYETIERVKERYPGLNIILKKPDLTLE EQAEEHGDKLWEREPNQCCYLRKVVPLREALSGHPAWLSGLRRDQGPSRANTNFLNKD EKFKSVKVCPLIHWTWKDIWRYTSRNELDYNPLHDQGYPSIGCAPCTSPAFTAEDLRS GRWNGMAKTECGLHE*" gene 1630382..1631083 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" CDS 1631095..1632159 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 10784039, 11004190, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 10784039, 11004190, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfate permease" /protein_id="NP_389441.1" /db_xref="EnsemblGenomes-Gn:BSU15580" /db_xref="EnsemblGenomes-Tr:CAB13432" /db_xref="GOA:O34734" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13377" /db_xref="UniProtKB/Swiss-Prot:O34734" /translation="MELAAILFSLFFAMNIGASGAAASMGVAYGSGAIKKKTYALILC AVGVFAGAVIGGGEVVKTISSGIIPEQTITLTIVCIIIGAAALSLFTANLLGIPLSTS EVTVGAVVGVGVAYKVLFVNNLLIIVSFWVFVPLFAFGFTYFVSKLFRYFKIEVKSSK KQKILGIVLLVAGFFEAFSAGMNNVANAVGPLVAAGVLDVGKGTLYGGAFVALGALLL GRRVLETNGKKITRFSKGEGILLSGTGAGLVIISSVFGMPVPLAQVTSSSIIGIGMAK NGPNVFHKQVVQTMLKVWIVSPFLSLSISYLLVSLFLKADYYSIFIMVSVLLAAGGAI SLTKAIRKERRSVHEQGGGI*" gene 1631095..1632159 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" CDS 1632208..1633356 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" /EC_number="2.7.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 11004190, 11274114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfate adenylyltransferase" /protein_id="NP_389442.1" /db_xref="EnsemblGenomes-Gn:BSU15590" /db_xref="EnsemblGenomes-Tr:CAB13433" /db_xref="GOA:O34764" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13378" /db_xref="UniProtKB/Swiss-Prot:O34764" /translation="MSLAPHGGTLVNRVDESYDVSGIQKEIELDLISFADLELIGIGA YSPIEGFFNEKDYVSVVENMRLSSGVVWSLPITLPVDAQKAAELSLGETVKLTYEGET YGVIQIEDLYVPDKQKEAVNVYKTDEQEHPGVKKLFSRGNTYVGGPITLIKKASKQFP EFTFEPSETRRQFAEKGWETIVGFQTRNPVHRAHEYIQKTALETVDGLFLNPLVGETK SDDIPADVRMESYQVLLDHYYPKDRVFLGVFLAAMRYAGPREAIFHALVRKNYGCTHF IVGRDHAGVGDYYGTYEAQELFDTFKPEELGITPLKFEHSFFCKKCGNMGTAKTCPHG REHHVILSGTKVRGMLRDGVLPPAEFSRKEVVEVLIKGMKKKEEVGVS*" gene 1632208..1633356 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" upshifts complement(1632297) /Source="Nicolas_upshifts" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1632309..1632313) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1632331..1632332) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1633369..1633962 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" /EC_number="2.7.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1332767, 10094622, 11004190, 19067028, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylylsulfate kinase" /protein_id="NP_389443.1" /db_xref="EnsemblGenomes-Gn:BSU15600" /db_xref="EnsemblGenomes-Tr:CAB13434" /db_xref="GOA:O34577" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13379" /db_xref="UniProtKB/Swiss-Prot:O34577" /translation="MTNRDIVWHEASITKEEYQQKNKHKSSILWLTGLSGSGKSTIAN AAARELFEQGYQVIVLDGDNIRHGLNRDLGFSDEDRKENIRRIGEVAKLFVQQGTIVI TAFISPFREDRQQVRELVEAGEFNEVYIKCDLDICEQRDPKGLYKKARNGEIPFFTGI DSPYEEPEAPELVLDSGQHDREACKNQLIEFVKQKLS*" gene 1633369..1633962 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" S_feature 1633963..1634060 /Source="Nicolas_S_feature" /locus_tag="new_1633963_1634060" /HighExp="MG 10, B36, MG 5, MG t5, B60, MG 15, MG 90, MG-0.2, MG 60, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S570" CDS 1634061..1634834 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" /EC_number="2.1.1.107" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1906874, 11004190, 10094622, 19154787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III and precorrin-1 C-methyltransferase" /protein_id="NP_389444.1" /db_xref="EnsemblGenomes-Gn:BSU15610" /db_xref="EnsemblGenomes-Tr:CAB13435" /db_xref="GOA:O34744" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG13380" /db_xref="UniProtKB/Swiss-Prot:O34744" /translation="MGKVYIVGAGPGDPDLLTIKALKAIEKADVILYDRLVNKEILQY AKEQADLIYCGKLPDFHTMKQETINRFLVKYAQKGKMVVRLKGGDPFVFGRGGEEAEC LSENGIPFEIIPGITSGIAAAAYAGIPVTHRDAGSNVAFVTGHYKKEEDFEEKWKALA TGIDTLVIYMGIKNVQQIERKLLENGRDGSTPAAFIHWGTTDKQKSVFCTVDTLSETV IKENITNPSLIVIGNVVNYHYKLEWFESELKKQDLSEAL*" gene 1634061..1634834 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" promotor_-35 1634739..1634746 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1634761..1634780 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1634762 /Source="Nicolas_upshifts" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" CDS 1634837..1635622 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" /EC_number="4.99.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirohydrochlorin ferrochelatase" /protein_id="NP_389445.1" /db_xref="EnsemblGenomes-Gn:BSU15620" /db_xref="EnsemblGenomes-Tr:CAB13436" /db_xref="GOA:O34632" /db_xref="InterPro:IPR002762" /db_xref="SubtiList:BG13381" /db_xref="UniProtKB/Swiss-Prot:O34632" /translation="MKQAILYVGHGSRVKKAQQEAAAFLEGCKAHISVPVQEISFLEL QEPTIETGFEACVKQGATHIAVVPLLLLTAAHAKHDIPEEIVRVASRYPSVRISYGKP IGIDEEVVKAVYHRMKDIGVPYENARVVLIGRGSSDPDVKRDVTGIANLLQEMVPVKE VIPCFLTACGPNYKEVFSELEKDDGITTFIVPYLLFTGMLMNEIEREVQKLKAHNPNV YLSSYIGFHPHVKNAFLNRVRETAANSEGQFDFDGGSYASAAH*" gene 1634837..1635622 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" CDS 1635603..1636091 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" /EC_number="1.3.1.76" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752, 18588505; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="precorrin-2 dehydrogenase" /protein_id="NP_389446.1" /db_xref="EnsemblGenomes-Gn:BSU15630" /db_xref="EnsemblGenomes-Tr:CAB13437" /db_xref="GOA:O34813" /db_xref="InterPro:IPR006367" /db_xref="InterPro:IPR028161" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13382" /db_xref="UniProtKB/Swiss-Prot:O34813" /translation="MLPLHISLEKKKVVIAGGGSIALRRLKTVISEGADITLVSPDVE PEIKQMAEERRIKWEKRTIEKEDYLNAFFIIAATDNAAVNKEIAQSASPFQLVNCVSD AELGNVYMPKIVKRGHVTVSVSTSGASPKHTKELAENVDKLIDGDFVAEVNRLYQMRR KK*" gene 1635603..1636091 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" downshifts 1636071 /Source="Nicolas_upshifts" /id="D875" /incds=0 /nref=256 /ntot=267 /MaxReadThrough="2.85828" /MaxDrop="8.90139" /score="26.5923498" /energy="-16.6" /TU="U1289" /idTUdmin="U1291" /TUdmin=0 /isTUend="TRUE" downshifts complement(1636118) /Source="Nicolas_upshifts" /id="D876" /incds=0 /nref=149 /ntot=238 /MaxReadThrough="1.71588" /MaxDrop="5.36964" /score="15.559144" /energy="-16.6" /TU="NA" /idTUdmin="U1292" /TUdmin=7 /isTUend="TRUE" CDS complement(1636131..1637849) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11238985, 17586671, 24646681, 28294433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA modification protein" /protein_id="NP_389447.1" /db_xref="EnsemblGenomes-Gn:BSU15640" /db_xref="EnsemblGenomes-Tr:CAB13438" /db_xref="InterPro:IPR008532" /db_xref="SubtiList:BG13383" /db_xref="UniProtKB/Swiss-Prot:O34693" /translation="MHMSFDGMFTYGMTHELNEKIMGGRITKIHQPYKHDVIFHIRAK GKNQKLLLSAHPSYSRVHITAQAYENPSEPPMFCMLLRKHIEGGFIEKIEQAGLDRIM IFHIKSRNEIGDETVRKLYVEIMGRHSNIILTDAAENVIIDGLKHLSPSMNSYRTVLP GQDYKLPPAQDKISPLEASEDDILRHLSFQEGRLDKQIVDHFSGVSPLFAKEAVHRAG LANKVTLPKALLALFAEVKEHRFIPNITTVNGKEYFYLLELTHLKGEARRFDSLSELL DRFYFGKAERDRVKQQAQDLERFVVNERKKNANKIKKLEKTLEYSENAKEFQLYGELL TANLYMLKKGDKQAEVINYYDEESPTITIPLNPNKTPSENAQAYFTKYQKAKNSVAVV EEQIRLAQEEIEYFDQLIQQLSSASPRDISEIREELVEGKYLRPKQQKGQKKQKPHNP VLETYESTSGLTILVGKNNRQNEYLTTRVAARDDIWLHTKDIPGSHVVIRSSEPDEQT IMEAATIAAYFSKAKDSSSVPVDYTKIRHVKKPNGAKPGFVTYDSQHTVFVTPDADTV IKLKKS*" gene complement(1636131..1637849) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" promotor_-10 complement(1637871..1637890) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1637885..1637890 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-35" upshifts complement(1637885) /Source="Nicolas_upshifts" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" promotor_-35 complement(1637903..1637908) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1637906..1637924 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-10" upshifts 1637910 /Source="Nicolas_upshifts" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" CDS 1637965..1640637 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12161109, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12161109, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="P-type calcium transport ATPase (sporulation)" /protein_id="NP_389448.1" /db_xref="EnsemblGenomes-Gn:BSU15650" /db_xref="EnsemblGenomes-Tr:CAB13439" /db_xref="GOA:O34431" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR004014" /db_xref="InterPro:IPR005782" /db_xref="InterPro:IPR006068" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13384" /db_xref="UniProtKB/Swiss-Prot:O34431" /translation="MKFHEMGQTDLLEATNTSMKQGLTEKEVKKRLDKHGPNELQEGK KTSALLLFFAQFKDFMVLVLLAATLISGFLGEYVDAVAIIAIVFVNGILGFFQERRAE QSLQALKELSTPHVMALREGSWTKIPSKELVPGDIVKFTSGDRIGADVRIVEARSLEI EESALTGESIPVVKHADKLKKPDVSLGDITNMAFMGTIVTRGSGVGVVVGTGMNTAMG KIADMLESAGTLSTPLQRRLEQLGKILIVVALLLTVLVVAVGVIQGHDLYSMFLAGVS LAVAAIPEGLPAIVTVALSLGVQRMIKQKSIVRKLPAVETLGCASIICSDKTGTMTQN KMTVTHVWSGGKTWRVAGAGYEPKGSFTLNEKEISVNEHKPLQQMLLFGALCNNSNIE KRDGEYVLDGDPTEGALLTAARKGGFSKEFVESNYRVIEEFPFDSARKMMTVIVENQD RKRYIITKGAPDVLMQRSSRIYYDGSAALFSNERKAETEAVLRHLASQALRTIAVAYR PIKAGETPSMEQAEKDLTMLGLSGIIDPPRPEVRQAIKECREAGIKTVMITGDHVETA KAIAKDLRLLPKSGKIMDGKMLNELSQEELSHVVEDVYVFARVSPEHKLKIVKAYQEN GHIVAMTGDGVNDAPAIKQADIGVSMGITGTDVAKEASSLVLVDDNFATIKSAIKEGR NIYENIRKFIRYLLASNVGEILVMLFAMLLALPLPLVPIQILWVNLVTDGLPAMALGM DQPEGDVMKRKPRHPKEGVFARKLGWKVVSRGFLIGVATILAFIIVYHRNPENLAYAQ TIAFATLVLAQLIHVFDCRSETSVFSRNPFQNLYLIGAVLSSILLMLVVIYYPPLQPI FHTVAITPGDWMLVIGMSAIPTFLLAGSLLTRKK*" gene 1637965..1640637 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" promotor_-10 complement(1639370..1639389) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1639381) /Source="Nicolas_upshifts" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1639404..1639411) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1640643..1640662 /Source="Nicolas_upshift_promotors" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1640646..1640719 /Source="Nicolas_S_feature" /locus_tag="new_1640646_1640719" /HighExp="LPhT, LBGstat, T3.0H, H2O2, T3.30H, Salt, B60, Lbexp, UNK1, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.994, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S571" upshifts 1640646 /Source="Nicolas_upshifts" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" CDS 1640720..1641595 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389449.1" /db_xref="EnsemblGenomes-Gn:BSU15660" /db_xref="EnsemblGenomes-Tr:CAB13440" /db_xref="InterPro:IPR005229" /db_xref="InterPro:IPR013527" /db_xref="InterPro:IPR013551" /db_xref="SubtiList:BG13385" /db_xref="UniProtKB/Swiss-Prot:O34441" /translation="MIRSMTGFGSASKTQDDLSVSVELKSVNYRFKEVNARLPRPLLY FEDKLKQTILQHIQRGRIELFVSVDSDMLVEKRLEIDWPLLDEFVAAARDMKKRYQLS AEPDVMDFFKLDHVVQVHEEQTQNDKLEALIIDAAEEAVKGLCEMREKEGLLLAKDCL MHIDQLEELVRETELLAADVVSRYRERLYARIKEWTEDVLDESRLVTECAIFADRSDI TEEITRLKSHFAQFRDILASGGAVGRKLDFLVQELNREANTIGSKANDHQITKLVVEM KSSIEKIKEQVQNIE*" gene 1640720..1641595 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" CDS 1641672..1641941 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116, 23396918, 23646920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116, 23396918, 23646920; Product type r: regulator" /codon_start=1 /transl_table=11 /product="essential sporulation DNA binding protein; regulator of biofilm formation" /protein_id="NP_570902.1" /db_xref="EnsemblGenomes-Gn:BSU15670" /db_xref="EnsemblGenomes-Tr:CAE01452" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG14185" /db_xref="UniProtKB/Swiss-Prot:Q7WY72" /translation="MTIKLINIGFGNIISANRMISIVSPESAPIKRMIQDARDRGMLI DATYGRRTRAVVVMDSDHIILSAVQPETVAHRLSVKEEIMDEGQG*" gene 1641672..1641941 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" misc_feature complement(1641752..1641756) /Source="Nicolas_upshift_promotors" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1641757) /Source="Nicolas_upshifts" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1641949..1642563 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" /EC_number="2.7.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17012781, 24722991" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17012781, 24722991; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanylate kinase" /protein_id="NP_389450.2" /db_xref="EnsemblGenomes-Gn:BSU15680" /db_xref="EnsemblGenomes-Tr:CAB13441" /db_xref="GOA:O34328" /db_xref="InterPro:IPR008144" /db_xref="InterPro:IPR008145" /db_xref="InterPro:IPR017665" /db_xref="InterPro:IPR020590" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13386" /db_xref="UniProtKB/Swiss-Prot:O34328" /translation="MKERGLLIVLSGPSGVGKGTVRQAIFSQEDTKFEYSISVTTRSP REGEVNGVDYFFKTRDEFEQMIADNKLLEWAEYVGNYYGTPVDYVEQTLQDGKDVFLE IEVQGALQVRNAFPEGLFIFLAPPSLSELKNRIVTRGTETDALIENRMKAAKAEIEMM DAYDYVVENDNVETACDKIKAIVLAEHLKRERVAPRYKKMLEVE*" gene 1641949..1642563 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" CDS 1642567..1642770 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12089032, 16159791, 17233676, 24476911, 25878038; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega subunit of RNA polymerase" /protein_id="NP_389451.1" /db_xref="EnsemblGenomes-Gn:BSU15690" /db_xref="EnsemblGenomes-Tr:CAB13442" /db_xref="GOA:O35011" /db_xref="InterPro:IPR003716" /db_xref="InterPro:IPR006110" /db_xref="InterPro:IPR012293" /db_xref="InterPro:IPR036161" /db_xref="SubtiList:BG13387" /db_xref="UniProtKB/Swiss-Prot:O35011" /translation="MLDPSIDSLMNKLDSKYTLVTVSARRAREMQIKKDQMIEHTISH KYVGKALEEIDAGLLSFEKEDRE*" gene 1642567..1642770 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" downshifts 1642759 /Source="Nicolas_upshifts" /id="D877" /incds=0 /nref=118 /ntot=257 /MaxReadThrough="5.65143" /MaxDrop="4.7291" /score="-8.13961715" /energy="-7.7" /TU="U1293,U1295" /idTUdmin="U1293" /TUdmin="-132" /isTUend="FALSE" CDS 1642851..1644071 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" /EC_number="4.1.1.36" /EC_number="6.3.2.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11278255, 11358972, 12140293, 14686929, 15530362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coenzyme A biosynthesis bifunctional protein CoaBC; phosphopantothenoylcysteine synthetase/decarboxylase" /protein_id="NP_389452.1" /db_xref="EnsemblGenomes-Gn:BSU15700" /db_xref="EnsemblGenomes-Tr:CAB13443" /db_xref="GOA:O35033" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR005252" /db_xref="InterPro:IPR007085" /db_xref="InterPro:IPR035929" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG13388" /db_xref="UniProtKB/Swiss-Prot:O35033" /translation="MLNNRNVLLCVSGGIAVYKACALTSKLVQAGANVKVIMTESACR FVSPLTFQALSRHEVYTDTFKEQNPSVISHIDAADWADLIIVAPATANVIGKLANGIA DDMLTTTLLAATAPVWIAPAMNVHMYDHPAVKRNISVLYQDGYCFIEPSEGYLACGYV GKGRLEEPENIVKLAEKHFAEETSAPLEGKHVVITAGPTREAIDPVRFFTNKSTGKMG YALAEAAVQLGARVILISGPVSLDQPKGLAEFIPVQSAADMREAVLSVYDASDIVIKT AAVADFTPKTVFDHKMKKQDGGMTLELKRTVDILKELGEKKKEQILVGFAAETQDIEH YARKKLAAKNLDLIVANDVKANGAGFGADTNIVTIFFKDGHKRELPIMSKLDVSFEIL QEIAALSKQTGERS*" gene 1642851..1644071 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" S_feature complement(1643910..1644485) /Source="Nicolas_S_feature" /locus_tag="new_1643910_1644485_c" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, B60, LPhT, HiTm, Heat" /AntisenseName="priA" /AntisenseCor="-5.1213364637925501E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S572" CDS 1644068..1646485 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10572298, 11917020, 12682299, 21170359, 22720735, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572298, 11917020, 12682299, 21170359, 22720735, 28527403; Product type f : factor" /codon_start=1 /transl_table=11 /product="primosomal replication factor Y (primosomal protein N')" /protein_id="NP_389453.1" /db_xref="EnsemblGenomes-Gn:BSU15710" /db_xref="EnsemblGenomes-Tr:CAB13444" /db_xref="GOA:P94461" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005259" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11963" /db_xref="UniProtKB/Swiss-Prot:P94461" /translation="MNFAEVIVDVSTKNIDRPFDYKIPDHLKGMIKTGMRVIVPFGPR KIQGFVTAVKEASDLSGKSVKEVEDLLDLTPVLTEELMILSSWLSDKTLSFKITALQA MLPAALKAKYEKELKIAHGADLPPQVERLFSETKTLLYSDIPDHETLKLIQRHVQKGD IDVTYKVAQKTNKKMVRHIQANASKEELAKQAEGLSRQAAKQQAILHFLISEPEGVKI PAAELCKKTDTSSATIKTLIQKGLLKESYEEVYRDPYQDKMFKKTEPLPLTDEQRAAF EPIRETLDSDEHKVFLLHGVTGSGKTEIYLQSIEKVLAKGKEAIVLVPEISLTPQMVN RFKGRFGSQVAVMHSGLSTGEKYDEWRKIHRKEVRLVVGARSAIFAPFENLGMIIIDE EHESSYKQEEMPRYHAKEVAIKRAEHHSCPVVLGSATPTLESYARAQKGVYELLSLKH RVNHRVMPEVSLVDMREELRNGNRSMFSVELMEKLEETIAKGEQAVLFLNKRGYSSFV MCRDCGYVPQCPHCDISMTYHRYGQRLKCHYCGHEEPVPHTCPECASEHIRFFGTGTQ RVEEELTKVLPSARVIRMDVDTTSRKGAHEKLLSAFGEGKADILLGTQMIAKGLDFPN VTLVGVLSADTTLHIPDFRSAEKTFQLLTQVSGRAGRHEKPGHVIIQTYTPSHYSIQL TKTHDYETFYQHEMAHRREQSYPPYYYLALVTVSHEEVAKAAVTAEKIAHFLKANCGA DTKILGPSASPIARIKDRYRYQCVIKYKQETQLSALLKKILEHYKREIEQKHVMISID MNPYMMM*" gene 1644068..1646485 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" promotor_-10 complement(1644481..1644499) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1644485) /Source="Nicolas_upshifts" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" promotor_-35 complement(1644513..1644519) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1646336..1646340 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1646356..1646375 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1646367 /Source="Nicolas_upshifts" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" CDS 1646512..1646994 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" /EC_number="3.5.1.88" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11429456, 16014871, 16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16014871, 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide deformylase" /protein_id="NP_389454.1" /db_xref="EnsemblGenomes-Gn:BSU15720" /db_xref="EnsemblGenomes-Tr:CAB13445" /db_xref="GOA:P94462" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11933" /db_xref="UniProtKB/Swiss-Prot:P94462" /translation="MAVKKVVTHPAEVLETPAETVTVFDKKLKKLLDDMYDTMLEMDG VGLAAPQIGILKRAAVVEIGDDRGRIDLVNPEILEKSGEQTGIEGCLSFPNVYGDVTR ADYVKVRAFNRQGKPFILEARGFLARAVQHEMDHLDGVLFTSKISKYYTEDELADMEG *" gene 1646512..1646994 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" CDS 1646999..1647952 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" /EC_number="2.1.2.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA formyltransferase" /protein_id="NP_389455.1" /db_xref="EnsemblGenomes-Gn:BSU15730" /db_xref="EnsemblGenomes-Tr:CAB13446" /db_xref="GOA:P94463" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR005793" /db_xref="InterPro:IPR005794" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036477" /db_xref="InterPro:IPR037022" /db_xref="SubtiList:BG11937" /db_xref="UniProtKB/Swiss-Prot:P94463" /translation="MTRIVFMGTPDFSVPVLRTLIEDGYEVVGVVTQPDRPKGRKKVL TPPPVKEEALRHGIPVLQPEKVRLTEEIEKVLALKPDLIVTAAFGQILPKELLDSPKY GCINVHASLLPELRGGAPIHYSILQGKKKTGITIMYMVEKLDAGDMISKVEVDIEETD NVGTLHDKLSVAGAKLLSETVPNVIAGSISPEKQDEEKATYAPNIKREQELLDWSRTG EELYNQIRGLNPWPVAYTTLNGQNLKIWASKKIAAPTTAEPGTVVAVEKEGIIVATGN ETALLLTELQPAGKKRMKGEDFVRGAHVEAGDVLGVNNEKN*" gene 1646999..1647952 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" CDS 1647939..1649282 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" /EC_number="2.1.1.176" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14656444, 23729652, 27698115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA-binding Sun protein; 16S rRNA m5C967 methyltransferase, S-adenosyl-L-methionine-dependent" /protein_id="NP_389456.1" /db_xref="EnsemblGenomes-Gn:BSU15740" /db_xref="EnsemblGenomes-Tr:CAB13447" /db_xref="GOA:P94464" /db_xref="InterPro:IPR001678" /db_xref="InterPro:IPR004573" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR018314" /db_xref="InterPro:IPR023267" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG12253" /db_xref="UniProtKB/Swiss-Prot:P94464" /translation="MKKTSVRDIALEALIKLEQNQAYSNLLLKSVIKSNELSDQNRGL LTELVYGTLQNKIALDYMLKPFINKPQKVKPWVIQLLRLSLYQMEYLEKIPDRAAIHE AVEIAKIRGHKGIASFVNGVLRSIQREGVPSFDAIEDPVRRLATETSHPEWLVKEWAD AYGFEAAEKICRIHLIPPKQTLRVNQMKADRAELLDQMAAEGIEVEKGDLAEDAVKLL KGTIAGTHFFQNGEVSIQDESSMLVARALDPKSDETVLDACAAPGGKSAHIAELMKNK GSVTSLDLHKHKVKLIKEAADRLGLTIIHAETMDARKAGETFENEQFDRILVDAPCSG FGVIRRKPDMKYTKKPDDSARLAEIQLSILREIAPLVKKGGTLVYSTCTMDRTENDEV IHAFIQEHPDFEPDLSLEKRLPEKVRPFVRDGRLQILPHYFGTDGFFICSMRKKG*" gene 1647939..1649282 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" CDS 1649286..1650377 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" /EC_number="2.1.1.192" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8973346, 18307109, 20184321, 21368151, 22891362, 27081063, 27902775; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2A2503 methyltransferase and tRNA A37 C2 methyltransferase" /protein_id="NP_389457.1" /db_xref="EnsemblGenomes-Gn:BSU15750" /db_xref="EnsemblGenomes-Tr:CAB13448" /db_xref="GOA:O34617" /db_xref="InterPro:IPR004383" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR027492" /db_xref="SubtiList:BG13389" /db_xref="UniProtKB/Swiss-Prot:O34617" /translation="MAELNKTKVRKELRTERPSIYSFELDEIKQWLTDNGEKPFRAAQ IFEWLYEKRVSSFEDMTNLSKDLREKLNTRFVLTTLKTAVKQTSQDGTMKFLFELHDG YTIETVLMRHEYGNSVCVTTQVGCRIGCTFCASTLGGLKRNLEAGEIVAQVVKVQKAL DETDERVSSVVIMGIGEPFDNFNEMLAFLKIINHDKGLNIGARHITVSTSGIIPKIYE FADQQMQINFAISLHAPNTEIRSRLMPINRAYKLPDLMEAVKYYINKTGRRISFEYGL FGGVNDQVEHAEELADLLEGVKCHVNLIPVNYVPERDYVRTPRDQIFAFEKTLKSRGV NVTIRREQGHDIDAACGQLRAKERQDETR*" gene 1649286..1650377 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" CDS 1650384..1651148 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" /EC_number="3.1.3.16" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 17693724, 22720735, 24390483, 25012659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 17693724, 22720735, 24390483, 25012659; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="multitarget phosphorylated protein phosphatase" /protein_id="NP_389458.1" /db_xref="EnsemblGenomes-Gn:BSU15760" /db_xref="EnsemblGenomes-Tr:CAB13449" /db_xref="GOA:O34779" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR015655" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG13390" /db_xref="UniProtKB/Swiss-Prot:O34779" /translation="MLTALKTDTGKIRQHNEDDAGIFKGKDEFILAVVADGMGGHLAG DVASKMAVKAMGEKWNEAETIPTAPSECEKWLIEQILSVNSKIYDHAQAHEECQGMGT TIVCALFTGKTVSVAHIGDSRCYLLQDDDFVQVTEDHSLVNELVRTGEISREDAEHHP RKNVLTKALGTDQLVSIDTRSFDIEPGDKLLLCSDGLTNKVEGTELKDILQSDSAPQE KVNLLVDKANQNGGEDNITAVLLELALQVEEGEDQC*" gene 1650384..1651148 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" downshifts 1650437 /Source="Nicolas_upshifts" /id="D878" /incds=0 /nref=5 /ntot=126 /MaxReadThrough="6.12318" /MaxDrop="3.8594" /score="-7.80200272" /energy="-10" /TU="U1295,U1298" /idTUdmin="U1300" /TUdmin="-4708" /isTUend="FALSE" CDS 1651142..1653088 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" /EC_number="2.7.11.1" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 18984160, 24390483, 25845974, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 18984160, 24390483, 25845974, 26102633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine/threonine kinase" /protein_id="NP_389459.1" /db_xref="EnsemblGenomes-Gn:BSU15770" /db_xref="EnsemblGenomes-Tr:CAB13450" /db_xref="GOA:O34507" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR008271" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13391" /db_xref="UniProtKB/Swiss-Prot:O34507" /translation="MLIGKRISGRYQILRVIGGGGMANVYLAEDIILDREVAIKILRF DYANDNEFIRRFRREAQSASSLDHPNIVSIYDLGEEDDIYYIVMEYVEGMTLKEYITA NGPLHPKEALNIMEQIVSAIAHAHQNQIVHRDIKPHNILIDHMGNIKVTDFGIATALS STTITHTNSVLGSVHYLSPEQARGGLATKKSDIYALGIVLFELLTGRIPFDGESAVSI ALKHLQAETPSAKRWNPSVPQSVENIILKATAKDPFHRYETAEDMEADIKTAFDADRL NEKRFTIQEDEEMTKAIPIIKDEELAKAAGEKEAEVTTAQENKTKKNGKRKKWPWVLL TICLVFITAGILAVTVFPSLFMPKDVKIPDVSGMEYEKAAGLLEKEGLQVDSEVLEIS DEKIEEGLMVKTDPKADTTVKEGATVTLYKSTGKAKTEIGDVTGQTVDQAKKALKDQG FNHVTVNEVNDEKNAGTVIDQNPSAGTELVPSEDQVKLTVSIGPEDITLRDLKTYSKE AASGYLEDNGLKLVEKEAYSDDVPEGQVVKQKPAAGTAVKPGNEVEVTFSLGPEKKPA KTVKEKVKIPYEPENEGDELQVQIAVDDADHSISDTYEEFKIKEPTERTIELKIEPGQ KGYYQVMVNNKVVSYKTIEYPKDE*" gene 1651142..1653088 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" promotor_-35 1652997..1653003 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1653017..1653035 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1653033 /Source="Nicolas_upshifts" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" CDS 1653103..1653999 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome biogenesis" /protein_id="NP_389460.1" /db_xref="EnsemblGenomes-Gn:BSU15780" /db_xref="EnsemblGenomes-Tr:CAB13451" /db_xref="GOA:O34530" /db_xref="InterPro:IPR004881" /db_xref="InterPro:IPR010914" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="InterPro:IPR031944" /db_xref="PDB:1T9H" /db_xref="SubtiList:BG13392" /db_xref="UniProtKB/Swiss-Prot:O34530" /translation="MPEGKIIKALSGFYYVLDESEDSDKVIQCRGRGIFRKNKITPLV GDYVVYQAENDKEGYLMEIKERTNELIRPPICNVDQAVLVFSAVQPSFSTALLDRFLV LVEANDIQPIICITKMDLIEDQDTEDTIQAYAEDYRNIGYDVYLTSSKDQDSLADIIP HFQDKTTVFAGQSGVGKSSLLNAISPELGLRTNEISEHLGRGKHTTRHVELIHTSGGL VADTPGFSSLEFTDIEEEELGYTFPDIREKSSSCKFRGCLHLKEPKCAVKQAVEDGEL KQYRYDHYVEFMTEIKDRKPRY*" gene 1653103..1653999 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" CDS 1654004..1654657 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" /EC_number="5.1.3.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 973353, 15755726, 16489742, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribulose-5-phosphate 3-epimerase" /protein_id="NP_389461.1" /db_xref="EnsemblGenomes-Gn:BSU15790" /db_xref="EnsemblGenomes-Tr:CAB13452" /db_xref="GOA:O34557" /db_xref="InterPro:IPR000056" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR026019" /db_xref="SubtiList:BG13393" /db_xref="UniProtKB/Swiss-Prot:O34557" /translation="MIKVAPSILSADFAALGNEIKDVEKGGADCIHIDVMDGHFVPNI TIGPLIVEAVRPVTDLPLDVHLMIEEPDRYIPAFAKAGADILSVHAEACPHLHRTIQL IKEQGVKAGVVLNPHTPVQVIEHVFDDLDLVLLMTVNPGFGGQKFIHSVLPKIKEVKR MADEKGKKDLLIEVDGGVNKETAPLVIEAGANLLVAGSAVYGQSDRKKAISEIRGSK* " gene 1654004..1654657 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" promotor_-35 1654655..1654664 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-35" promotor_-10 1654678..1654697 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-10" upshifts 1654683 /Source="Nicolas_upshifts" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" CDS 1654730..1655374 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" /EC_number="2.7.6.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14567704, 15150256, 16291685, 19490098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine pyrophosphokinase" /protein_id="NP_389462.1" /db_xref="EnsemblGenomes-Gn:BSU15800" /db_xref="EnsemblGenomes-Tr:CAB13453" /db_xref="GOA:O34664" /db_xref="InterPro:IPR006282" /db_xref="InterPro:IPR007371" /db_xref="InterPro:IPR007373" /db_xref="InterPro:IPR036371" /db_xref="InterPro:IPR036759" /db_xref="PDB:3LM8" /db_xref="SubtiList:BG13394" /db_xref="UniProtKB/Swiss-Prot:O34664" /translation="MKTINIVAGGPKNLIPDLTGYTDEHTLWIGVDKGTVTLLDAGII PVEAFGDFDSITEQERRRIEKAAPALHVYQAEKDQTDLDLALDWALEKQPDIIQIFGI TGGRADHFLGNIQLLYKGVKTNIKIRLIDKQNHIQMFPPGEYDIEKDENKRYISFIPF SEDIHELTLTGFKYPLNNCHITLGSTLCISNELIHSRGTFSFAKGILIMIRSTD*" gene 1654730..1655374 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" promotor_-35 1655135..1655141 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-35" upshifts 1655152 /Source="Nicolas_upshifts" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" promotor_-10 1655156..1655174 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-10" promotor_-35 1655265..1655270 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1655286..1655304 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1655299 /Source="Nicolas_upshifts" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" S_feature 1655375..1655445 /Source="Nicolas_S_feature" /locus_tag="new_1655375_1655445" /HighExp="S4, S5, S7, S8, S6, S3, B36, G/S, B60, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigB, SigA, SigA" /TUshortPSig="0.977, 0.548, 0.973, 1, 0.994" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S573" CDS 1655446..1655526 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for normal spore cortex and coatsynthesis (stage V sporulation)" /protein_id="NP_389463.1" /db_xref="EnsemblGenomes-Gn:BSU15810" /db_xref="EnsemblGenomes-Tr:CAB13454" /db_xref="GOA:P37817" /db_xref="InterPro:IPR012609" /db_xref="PDB:2MVH" /db_xref="PDB:2MVJ" /db_xref="SubtiList:BG10776" /db_xref="UniProtKB/Swiss-Prot:P37817" /translation="MKFYTIKLPKFLGGIVRAMLGSFRKD*" gene 1655446..1655526 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" downshifts 1655541 /Source="Nicolas_upshifts" /id="D879" /incds=0 /nref=178 /ntot=258 /MaxReadThrough="4.05442" /MaxDrop="7.745" /score="7.47691609" /energy="-16.9" /TU="U1301,U1302" /idTUdmin="U1295" /TUdmin=0 /isTUend="TRUE" S_feature 1655586..1655958 /Source="Nicolas_S_feature" /locus_tag="new_1655586_1655958" /HighExp="S4, S5, T5.0H, S3, S6, S8, S7, T4.0H, LoTm, T3.30H" /AntisenseName="rpmB" /AntisenseCor="-0.40376097579549802" /AntisenseRegPval="-11.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.977, 0.548" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S574" CDS complement(1655599..1655787) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8722036; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L28" /protein_id="NP_389464.1" /db_xref="EnsemblGenomes-Gn:BSU15820" /db_xref="EnsemblGenomes-Tr:CAB13455" /db_xref="GOA:P37807" /db_xref="InterPro:IPR001383" /db_xref="InterPro:IPR026569" /db_xref="InterPro:IPR034704" /db_xref="InterPro:IPR037147" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10777" /db_xref="UniProtKB/Swiss-Prot:P37807" /translation="MARKCVITGKKTTAGNNRSHAMNASKRTWGANLQKVRILVNGKP KKVYVSARALKSGKVERV*" gene complement(1655599..1655787) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" downshifts complement(1655615) /Source="Nicolas_upshifts" /id="D880" /incds=0 /nref=216 /ntot=298 /MaxReadThrough="2.59598" /MaxDrop="7.48719" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-20" /isTUend="TRUE" downshifts complement(1655661) /Source="Nicolas_upshifts" /id="D881" /incds=1 /nref=1 /ntot=18 /MaxReadThrough="7.6779" /MaxDrop="3.1786" /score="15.2403969" /energy="-14.3" /TU="U1303" /idTUdmin="U1303" /TUdmin="-66" /isTUend="FALSE" S_feature complement(1655788..1655880) /Source="Nicolas_S_feature" /locus_tag="new_1655788_1655880_c" /HighExp="HPh, LPh, HiOs, LBGexp, aero, G180, GM 15, dia0, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S575" promotor_-10 complement(1655862..1655881) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1655880) /Source="Nicolas_upshifts" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" promotor_-35 complement(1655897..1655900) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1655931..1655938 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1655953..1655971 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1655960 /Source="Nicolas_upshifts" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" promotor_-35 1655999..1656002 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1656017..1656036 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1656025 /Source="Nicolas_upshifts" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" CDS 1656064..1656426 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 17114254, 24178028, 28579978; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor involved in malonyl-CoA synthesis" /protein_id="NP_389465.1" /db_xref="EnsemblGenomes-Gn:BSU15830" /db_xref="EnsemblGenomes-Tr:CAB13456" /db_xref="InterPro:IPR005531" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG13395" /db_xref="UniProtKB/Swiss-Prot:O34318" /translation="MSIELRTKYGQIDISNEVIAMVAGGAAVDCYGIVGMASKNQIKD GLTEILRKENFSRGVQVRQEGEQIHIDMYIIVSYGTKISEVAHNVQTKVKYTVNQTIG LAVDSVNIYVQGVRVTNP*" gene 1656064..1656426 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" downshifts complement(1656277) /Source="Nicolas_upshifts" /id="D882" /incds=1 /nref=1 /ntot=143 /MaxReadThrough="1.75412" /MaxDrop="2.71497" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-682" /isTUend="FALSE" CDS 1656442..1658103 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16647083, 22333191, 22517742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme structurally related to dihydroxyacetone/glyceraldehyde kinase" /protein_id="NP_389466.1" /db_xref="EnsemblGenomes-Gn:BSU15840" /db_xref="EnsemblGenomes-Tr:CAB13457" /db_xref="GOA:O34751" /db_xref="InterPro:IPR004007" /db_xref="InterPro:IPR019986" /db_xref="InterPro:IPR033470" /db_xref="InterPro:IPR036117" /db_xref="SubtiList:BG13396" /db_xref="UniProtKB/Swiss-Prot:O34751" /translation="MSIRTLDGRTFAEMILAGAQNLSQNASAVDALNVFPVPDGDTGT NMNLSMTSGAREVEQMDTDDIGKVGSALSKGLLMGARGNSGVILSQLFRGFSKNIETK KEINALEFAAALQAGVDMAYKAVMKPVEGTILTVAKDAAKKAMILAEKETDITALMTA VTEEAEASLNRTPELLPVLKEVGVVDSGGKGLLCVYEGFLASLKGETVPQKAVLPSLD DMVSAEHHKSAQSMMNTEDIEFGFCTEVMVRLDQTKREFDEGTFRQDLSQFGDSLLVI ADESLAKVHIHAEEPGNVLNYAQHYGELIKIKIENMREQHTSIISQESKPADNETPPA KQPYGIVTVAMGEGIADLFKSIGASVVIEGGQTMNPSTEDIVDAVKSVNADTVFILPN NSNIIMAANQAASVVDEQVFVIPAKTVPQGMSALLAFNPDQEAEANEANMLSAIQQVK SGQVTFSVRDTHIDGKDIKKGDFMGILNGTIIGTSENQLSAAKMLLSEMIGEDDEIVT ILYGEDASQEEAEQLEAFLSEKYEEIEVEIHNGKQPLYSYIVSAE*" gene 1656442..1658103 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" S_feature 1658104..1658193 /Source="Nicolas_S_feature" /locus_tag="new_1658104_1658193" /HighExp="G135, G180, G150, LBGexp, Oxctl, Paraq, dia0, LPh, Lbexp, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37023200000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.991, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S576" promotor_-35 1658166..1658173 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-35" promotor_-10 1658187..1658206 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-10" upshifts 1658195 /Source="Nicolas_upshifts" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" CDS 1658242..1658904 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8385012, 9244285, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385012, 9244285, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (beta chain)" /protein_id="NP_389467.1" /db_xref="EnsemblGenomes-Gn:BSU15850" /db_xref="EnsemblGenomes-Tr:CAB13458" /db_xref="GOA:O34635" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004643" /db_xref="InterPro:IPR005131" /db_xref="InterPro:IPR029009" /db_xref="SubtiList:BG13397" /db_xref="UniProtKB/Swiss-Prot:O34635" /translation="MKYRSVFDIIGPVMIGPSSSHTAGAARIGRVARSLFGREPERII VSFYGSFAETYKGHGTDVAIIGGLLDFDTFDERIKTAIQIAEAKGIDIEFRVEDAVPV HPNTAKITISDEKGELELTGISIGGGKIEITELNGFELRLSGNHPAILVVHNDKFGTI AGVANVLAKFSINVGHMEVARKDIGQLALMTIEVDQNIDDHILDELSKLPNIIQVTKI AD*" gene 1658242..1658904 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" CDS 1658930..1659832 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2504697, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2504697, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (alpha chain)" /protein_id="NP_389468.1" /db_xref="EnsemblGenomes-Gn:BSU15860" /db_xref="EnsemblGenomes-Tr:CAB13459" /db_xref="GOA:O34607" /db_xref="InterPro:IPR004642" /db_xref="InterPro:IPR005130" /db_xref="SubtiList:BG13398" /db_xref="UniProtKB/Swiss-Prot:O34607" /translation="MFRNVKELIEITKEKQILISDVMIAQEMEVTEKTKEDIFQQMDH NLSVMEAAVQKGLEGVTSQTGLTGGDAVKLQAYIRSGKSLSGPLILDAVSKAVATNEV NAAMGTICATPTAGSAGVVPGTLFAVKEKLNPTREQMIRFLFTAGAFGFVVANNASIS GAAGGCQAEVGSASGMAAAAIVEMAGGTPEQSAEAMAITLKNMLGLVCDPVAGLVEVP CVKRNAMGASNAMIAADMALAGITSRIPCDEVIDAMYKIGQTMPTALRETGQGGLAAT PTGRELEKKIFGGALGSRETTSAN*" gene 1658930..1659832 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" CDS 1659810..1661858 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branch migrating ATP-dependent DNA helicase involved in DNA recombination and repair" /protein_id="NP_389469.1" /db_xref="EnsemblGenomes-Gn:BSU15870" /db_xref="EnsemblGenomes-Tr:CAB13460" /db_xref="GOA:O34942" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR004609" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033454" /db_xref="SubtiList:BG13399" /db_xref="UniProtKB/Swiss-Prot:O34942" /translation="MKQHQQTSIANIKGIGPETEKTLNELGIYDISDLLNYFPYRYDD YELRDLEEVKHDERVTVEGKVHSEPSLTYYGKKRNRLTFRLLVGHYLITAVCFNRPYL KKKLSLGSVVTVSGKWDKHRQTISVQELKNGPHQEDKSIEPVYSVKENVTVKMMRRFI QQALTQYADSLPDPLPEKLRKSYKLPDYYQALKAMHQPETREALKLARRRFVYEEFLL FQLKMQAFRKAEREQTQGIRQRFSNEELMRFIKSLPFPLTNAQSRVLREITADMSSPY RMNRLLQGDVGSGKTAVAAIALYAAILSGYQGALMVPTEILAEQHADSLVSLFEKWDV SVALLTSSVKGKRRKELLERLAAGEIDILVGTHALIQDEVEFKALSLVITDEQHRFGV EQRKKLRNKGQDPDVLFMTATPIPRTLAITVFGEMDVSVIDEMPAGRKRIETYWVKHD MLDRILAFVEKELKQGRQAYIICPLIEESDKLDVQNAIDVYNMLSDIFRGKWNVGLMH GKLHSDEKDQVMREFSANHCQILVSTTVVEVGVNVPNATIMVIYDADRFGLSQLHQLR GRVGRGEHQSFCILMADPKSETGKERMRIMSETNDGFELSEKDLELRGPGDFFGKKQS GMPEFKVADMVHDYRALETARQDAANLVASDAFWKEPEYAVLRDELLKSGVMDGEKLS *" gene 1659810..1661858 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" promotor_-35 1661894..1661901 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1661916..1661935 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1661922 /Source="Nicolas_upshifts" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" CDS 1661967..1662533 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12737802, 17962296, 20201588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12737802, 17962296, 20201588, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription factor controlling fatty acid and phospholipid metabolism (FapR-malonyl-Coa)" /protein_id="NP_389470.1" /db_xref="EnsemblGenomes-Gn:BSU15880" /db_xref="EnsemblGenomes-Tr:CAB13461" /db_xref="GOA:O34835" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR017275" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="PDB:2F3X" /db_xref="PDB:2F41" /db_xref="SubtiList:BG13400" /db_xref="UniProtKB/Swiss-Prot:O34835" /translation="MRRNKRERQELLQQTIQATPFITDEELAGKFGVSIQTIRLDRLE LSIPELRERIKNVAEKTLEDEVKSLSLDEVIGEIIDLELDDQAISILEIKQEHVFSRN QIARGHHLFAQANSLAVAVIDDELALTASADIRFTRQVKQGERVVAKAKVTAVEKEKG RTVVEVNSYVGEEIVFSGRFDMYRSKHS*" gene 1661967..1662533 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" CDS 1662547..1663548 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphate:acyl-ACP acyltransferase" /protein_id="NP_389471.1" /db_xref="EnsemblGenomes-Gn:BSU15890" /db_xref="EnsemblGenomes-Tr:CAB13462" /db_xref="GOA:P71018" /db_xref="InterPro:IPR003664" /db_xref="InterPro:IPR012281" /db_xref="PDB:1VI1" /db_xref="SubtiList:BG11843" /db_xref="UniProtKB/Swiss-Prot:P71018" /translation="MRIAVDAMGGDHAPKAVIDGVIKGIEAFDDLHITLVGDKTTIES HLTTTSDRITVLHADEVIEPTDEPVRAVRRKKNSSMVLMAQEVAENRADACISAGNTG ALMTAGLFIVGRIKGIDRPALAPTLPTVSGDGFLLLDVGANVDAKPEHLVQYAIMGSV YSQQVRGVTSPRVGLLNVGTEDKKGNELTKQTFQILKETANINFIGNVEARDLLDDVA DVVVTDGFTGNVTLKTLEGSALSIFKMMRDVMTSTLTSKLAAAVLKPKLKEMKMKMEY SNYGGASLFGLKAPVIKAHGSSDSNAVFHAIRQAREMVSQNVAALIQEEVKEEKTDE* " gene 1662547..1663548 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" CDS 1663567..1664520 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" /EC_number="2.3.1.39" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586097, 19850612" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586097, 19850612; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malonyl CoA:acyl carrier protein transacylase" /protein_id="NP_389472.1" /db_xref="EnsemblGenomes-Gn:BSU15900" /db_xref="EnsemblGenomes-Tr:CAB13463" /db_xref="GOA:P71019" /db_xref="InterPro:IPR004410" /db_xref="InterPro:IPR014043" /db_xref="InterPro:IPR016035" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR020801" /db_xref="InterPro:IPR024925" /db_xref="SubtiList:BG11836" /db_xref="UniProtKB/Swiss-Prot:P71019" /translation="MSKIAFLFPGQGSQFIGMGKELYEQVPAAKRLFDEADETLETKL SSLIFEGDAEELTLTYNAQPALLTTSIAVLEKFKESGITPDFTAGHSLGEYSALVAAG ALSFKDAVYTVRKRGEFMNEAVPAGEGAMAAILGMDAEALKQVTDKVTEEGNLVQLAN LNCPGQIVISGTAKGVELASELAKENGAKRAIPLEVSGPFHSELMKPAAEKLKEVLDA CDIKDADVPVISNVSADVMTEKADIKEKLIEQLYSPVRFEESINKLIAEGVTTFIEIG PGKVLSGLVKKVNRRLKTIAVSDPETIELAIQTLKEENDNA*" gene 1663567..1664520 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" CDS 1664513..1665253 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" /EC_number="1.1.1.100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12655455, 12682299, 19850612, 28126742" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12655455, 12682299, 19850612, 28126742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein reductase" /protein_id="NP_389473.1" /db_xref="EnsemblGenomes-Gn:BSU15910" /db_xref="EnsemblGenomes-Tr:CAB13464" /db_xref="GOA:P51831" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011284" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11535" /db_xref="UniProtKB/Swiss-Prot:P51831" /translation="MLNDKTAIVTGASRGIGRSIALDLAKSGANVVVNYSGNEAKANE VVDEIKSMGRKAIAVKADVSNPEDVQNMIKETLSVFSTIDILVNNAGITRDNLIMRMK EDEWDDVININLKGVFNCTKAVTRQMMKQRSGRIINVSSIVGVSGNPGQANYVAAKAG VIGLTKSSAKELASRNITVNAIAPGFISTDMTDKLAKDVQDEMLKQIPLARFGEPSDV SSVVTFLASEGARYMTGQTLHIDGGMVM*" gene 1664513..1665253 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" promotor_-35 1665284..1665288 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1665304..1665323 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1665309 /Source="Nicolas_upshifts" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" CDS 1665337..1665570 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 19850612, 27467752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 19850612, 27467752; Product type c: carrier" /codon_start=1 /transl_table=11 /product="acyl carrier protein" /protein_id="NP_389474.1" /db_xref="EnsemblGenomes-Gn:BSU15920" /db_xref="EnsemblGenomes-Tr:CAB13465" /db_xref="GOA:P80643" /db_xref="InterPro:IPR003231" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:1F80" /db_xref="PDB:1HY8" /db_xref="PDB:2X2B" /db_xref="SubtiList:BG11536" /db_xref="UniProtKB/Swiss-Prot:P80643" /translation="MADTLERVTKIIVDRLGVDEADVKLEASFKEDLGADSLDVVELV MELEDEFDMEISDEDAEKIATVGDAVNYIQNQQ*" gene 1665337..1665570 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" downshifts 1665551 /Source="Nicolas_upshifts" /id="D883" /incds=0 /nref=22 /ntot=197 /MaxReadThrough="8.12206" /MaxDrop="4.1545" /score="-8.42930766" /energy="-17.4" /TU="U1306,U1307,U1308" /idTUdmin="U1306" /TUdmin="-880" /isTUend="FALSE" promotor_no_box 1665579..1665679 /Source="Nicolas_upshift_promotors" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 1665639..1665709 /Source="Nicolas_S_feature" /locus_tag="new_1665639_1665709" /HighExp="LBGstat, dia5, Cold, LBGtran, C30, Diami, G135, LBGexp, G/S, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA, SigA" /TUshortPSig="0.031, 1, 1, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="0.991, 0.991" /label="S577" upshifts 1665639 /Source="Nicolas_upshifts" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" CDS 1665710..1666459 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" /EC_number="3.1.26.3" /experiment="publication(s) with functional evidences, PMID:11123676, 12682299, 16179796, 22412379, 23300471, 26883633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11123676, 12682299, 16179796, 22412379, 23300471, 26883633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease III" /protein_id="NP_389475.1" /db_xref="EnsemblGenomes-Gn:BSU15930" /db_xref="EnsemblGenomes-Tr:CAB13466" /db_xref="GOA:P51833" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR011907" /db_xref="InterPro:IPR014720" /db_xref="InterPro:IPR036389" /db_xref="SubtiList:BG11537" /db_xref="UniProtKB/Swiss-Prot:P51833" /translation="MSKHSHYKDKKKFYKKVEQFKEFQERISVHFQNEKLLYQAFTHS SYVNEHRKKPYEDNERLEFLGDAVLELTISRFLFAKYPAMSEGDLTKLRAAIVCEPSL VSLAHELSFGDLVLLGKGEEMTGGRKRPALLADVFEAFIGALYLDQGLEPVESFLKVY VFPKINDGAFSHVMDFKSQLQEYVQRDGKGSLEYKISNEKGPAHNREFEAIVSLKGEP LGVGNGRSKKEAEQHAAQEALAKLQKHHTKQ*" gene 1665710..1666459 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" downshifts 1666431 /Source="Nicolas_upshifts" /id="D884" /incds=0 /nref=78 /ntot=211 /MaxReadThrough="6.42554" /MaxDrop="5.70849" /score="-8.42930766" /energy="-17.4" /TU="U1307,U1308,U1309" /idTUdmin="U1306" /TUdmin=0 /isTUend="TRUE" promotor_-35 1666501..1666507 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1666519..1666538 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1666541 /Source="Nicolas_upshifts" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" CDS 1666560..1670120 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation SMC ATPase" /protein_id="NP_389476.2" /db_xref="EnsemblGenomes-Gn:BSU15940" /db_xref="EnsemblGenomes-Tr:CAB13467" /db_xref="GOA:P51834" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR010935" /db_xref="InterPro:IPR011890" /db_xref="InterPro:IPR024704" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036277" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5NMO" /db_xref="PDB:5NNV" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG11538" /db_xref="UniProtKB/Swiss-Prot:P51834" /translation="MFLKRLDVIGFKSFAERISVDFVKGVTAVVGPNGSGKSNITDAI RWVLGEQSARSLRGGKMEDIIFAGSDSRKRLNLAEVTLTLDNDDHFLPIDFHEVSVTR RVYRSGESEFLINNQPCRLKDIIDLFMDSGLGKEAFSIISQGKVEEILSSKAEDRRSI FEEAAGVLKYKTRKKKAENKLFETQDNLNRVEDILHELEGQVEPLKIQASIAKDYLEK KKELEHVEIALTAYDIEELHGKWSTLKEKVQMAKEEELAESSAISAKEAKIEDTRDKI QALDESVDELQQVLLVTSEELEKLEGRKEVLKERKKNAVQNQEQLEEAIVQFQQKETV LKEELSKQEAVFETLQAEVKQLRAQVKEKQQALSLHNENVEEKIEQLKSDYFELLNSQ ASIRNELQLLDDQMSQSAVTLQRLADNNEKHLQERHDISARKAACETEFARIEQEIHS QVGAYRDMQTKYEQKKRQYEKNESALYQAYQYVQQARSKKDMLETMQGDFSGFYQGVK EVLKAKERLGGIRGAVLELISTEQKYETAIEIALGASAQHVVTDDEQSARKAIQYLKQ NSFGRATFLPLSVIRDRQLQSRDAETAARHSSFLGVASELVTFDPAYRSVIQNLLGTV LITEDLKGANELAKLLGHRYRIVTLEGDVVNPGGSMTGGAVKKKNNSLLGRSRELEDV TKRLAEMEEKTALLEQEVKTLKHSIQDMEKKLADLRETGEGLRLKQQDVKGQLYELQV AEKNINTHLELYDQEKSALSESDEERKVRKRKLEEELSAVSEKMKQLEEDIDRLTKQK QTQSSTKESLSNELTELKIAAAKKEQACKGEEDNLARLKKELTETELALKEAKEDLSF LTSEMSSSTSGEEKLEEAAKHKLNDKTKTIELIALRRDQRIKLQHGLDTYERELKEMK RLYKQKTTLLKDEEVKLGRMEVELDNLLQYLREEYSLSFEGAKEKYQLETDPEEARKR VKLIKLAIEELGTVNLGSIDEFERVNERYKFLSEQKEDLTEAKNTLFQVIEEMDEEMT KRFNDTFVQIRSHFDQVFRSLFGGGRAELRLTDPNDLLHSGVEIIAQPPGKKLQNLNL LSGGERALTAIALLFSILKVRPVPFCVLDEVEAALDEANVFRFAQYLKKYSSDTQFIV ITHRKGTMEEADVLYGVTMQESGVSKVISVKLEETKEFVQ*" gene 1666560..1670120 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" S_feature complement(1670054..1671124) /Source="Nicolas_S_feature" /locus_tag="new_1670054_1671124_c" /HighExp="Cold, C30, Gly, T0.30H, Pyr, T-4.40H, G135, Lbstat, Fru, T-5.40H" /AntisenseName="ftsY" /AntisenseCor="-3.7172405649441298E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S578" CDS 1670140..1671129 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal recognition particle (docking protein)" /protein_id="NP_389477.1" /db_xref="EnsemblGenomes-Gn:BSU15950" /db_xref="EnsemblGenomes-Tr:CAB13468" /db_xref="GOA:P51835" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004390" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036225" /db_xref="SubtiList:BG11539" /db_xref="UniProtKB/Swiss-Prot:P51835" /translation="MSFFKKLKEKITKQTDSVSEKFKDGLEKTRNSFQNKVNDLVSRY RKVDEDFFEELEEVLISADVGFTTVMELIDELKKEVKRRNIQDPKEVQSVISEKLVEI YNSGDEQISELNIQDGRLNVILLVGVNGVGKTTTIGKLAHKMKQEGKSVVLAAGDTFR AGAIEQLEVWGERTGVPVIKQTAGSDPAAVIYDAVHAAKARNADVLICDTAGRLQNKV NLMKELEKVKRVIEREVPEAPHEVLLALDATTGQNAMAQAKEFSKATNVTGIALTKLD GTAKGGIVLAIRNELHIPVKLVGLGEKVDDLQEFDPESYVYGLFSDLVEKADD*" gene 1670140..1671129 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" downshifts 1671116 /Source="Nicolas_upshifts" /id="D885" /incds=0 /nref=220 /ntot=261 /MaxReadThrough="2.98458" /MaxDrop="6.84303" /score="49.5808683" /energy="-14.4" /TU="NA" /idTUdmin="U1307" /TUdmin="-1" /isTUend="TRUE" CDS complement(1671166..1671651) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535, 22287527" /codon_start=1 /transl_table=11 /product="conserved exported protein of unknown function" /protein_id="NP_389478.1" /db_xref="EnsemblGenomes-Gn:BSU15960" /db_xref="EnsemblGenomes-Tr:CAB13469" /db_xref="GOA:O31737" /db_xref="InterPro:IPR008969" /db_xref="InterPro:IPR008979" /db_xref="SubtiList:BG13401" /db_xref="UniProtKB/Swiss-Prot:O31737" /translation="MKKIGLLFMLCLAALFTIGFPAQQADAAEAPYKASITNISTDGG VYGKINYGQGQYWRVKYNITVSGKLLDQNGQPVPNAPVRFEADTKVGNTTQTASGTTD ANGTFEVPMYLGPAAGYYTYYTSVSVHYYDIIPFRVFSGESRLVSTDNSLYHFAYQVR R*" gene complement(1671166..1671651) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" downshifts complement(1671169) /Source="Nicolas_upshifts" /id="D886" /incds=0 /nref=139 /ntot=244 /MaxReadThrough="6.77251" /MaxDrop="6.10895" /score="32.8428224" /energy="-14.4" /TU="U1311" /idTUdmin="U1311" /TUdmin="-1076" /isTUend="FALSE" promotor_-10 complement(1671673..1671691) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1671689) /Source="Nicolas_upshifts" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" promotor_-35 complement(1671705..1671712) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1671754..1671760 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1671775..1671794 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1671777 /Source="Nicolas_upshifts" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1671828..1672160 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11274114, 24659773; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the signal recognition particle (SRP) protein-targeting pathway" /protein_id="NP_389479.1" /db_xref="EnsemblGenomes-Gn:BSU15970" /db_xref="EnsemblGenomes-Tr:CAB13470" /db_xref="GOA:P37104" /db_xref="InterPro:IPR007394" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10829" /db_xref="UniProtKB/Swiss-Prot:P37104" /translation="MSLEKTTRMNYLFDFYQSLLTSKQKSYMSLYYLDDFSLGEIAEE YEVSRQAVYDNIKRTEAMLEQYEEKLLLLKKFQERKEMFNKLKELASGSKEEEEITAL IEALEKLD*" gene 1671828..1672160 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" downshifts complement(1671831) /Source="Nicolas_upshifts" /id="D887" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="1.40385" /MaxDrop="4.6092" /score="32.8428224" /energy="-14.4" /TU="NA" /idTUdmin="U1311" /TUdmin="-1738" /isTUend="FALSE" CDS 1672174..1673514 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="signal recognition particle-like (SRP) GTPase" /protein_id="NP_389480.1" /db_xref="EnsemblGenomes-Gn:BSU15980" /db_xref="EnsemblGenomes-Tr:CAB13471" /db_xref="GOA:P37105" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004125" /db_xref="InterPro:IPR004780" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR022941" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036891" /db_xref="PDB:4UE4" /db_xref="SubtiList:BG10830" /db_xref="UniProtKB/Swiss-Prot:P37105" /translation="MAFEGLADRLQQTISKIRGKGKVSEQDVKEMMREVRLALLEADV NFKVVKDFVKKVSERAVGQDVMKSLTPGQQVIKVVQEELTELMGGEESKIAVAKRPPT VIMMVGLQGAGKTTTSGKLANLLRKKHNRKPMLVAADIYRPAAIKQLETLGKQLDMPV FSLGDQVSPVEIAKQAIEKAKEEHYDYVILDTAGRLHIDHELMDELTNVKEIANPEEI FLVVDSMTGQDAVNVAKSFNEQLGLTGVVLTKLDGDTRGGAALSIRAVTNTPIKFAGL GEKLDALEPFHPERMASRILGMGDVLTLIEKAQASVDEDKAKELEQKMRTMSFTLDDF LEQLGQVRNMGPLDELLQMMPGAGKMKGLKNIQVDEKQLNHVEAIIKSMTVLEKEQPD IINASRRKRIAKGSGTSVQEVNRLLKQFDEMKKMMKQMTNMSKGKKKGFKLPFM*" gene 1672174..1673514 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" S_feature 1673515..1673619 /Source="Nicolas_S_feature" /locus_tag="new_1673515_1673619" /HighExp="Cold, G135, C30, G180, LPhT, HPh, Paraq, LPh, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S579" CDS 1673620..1673892 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6419023, 12682299, 20034956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6419023, 12682299, 20034956; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S16 (BS17)" /protein_id="NP_389481.1" /db_xref="EnsemblGenomes-Gn:BSU15990" /db_xref="EnsemblGenomes-Tr:CAB13472" /db_xref="GOA:P21474" /db_xref="InterPro:IPR000307" /db_xref="InterPro:IPR020592" /db_xref="InterPro:IPR023803" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10831" /db_xref="UniProtKB/Swiss-Prot:P21474" /translation="MAVKIRLKRMGAKKSPFYRIVVADSRSPRDGRFIETVGTYNPVA KPAEVKIDEELALKWLQTGAKPSDTVRNLFSSQGIMEKFHNAKQGK*" gene 1673620..1673892 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" CDS 1673892..1674137 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735, 26483775; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_389482.1" /db_xref="EnsemblGenomes-Gn:BSU16000" /db_xref="EnsemblGenomes-Tr:CAB13473" /db_xref="GOA:O31738" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020627" /db_xref="SubtiList:BG13402" /db_xref="UniProtKB/Swiss-Prot:O31738" /translation="MTDQHLEDLIVHIVTPLVDHPDDIRVIREETDQKIALRLSVHKS DTGKVIGKQGRTAKAIRTAVFAAGVQSSKKVQFEIFD*" gene 1673892..1674137 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" downshifts 1674109 /Source="Nicolas_upshifts" /id="D888" /incds=0 /nref=41 /ntot=178 /MaxReadThrough="6.57974" /MaxDrop="4.803" /score="-7.01631592" /energy="-5.6" /TU="U1312" /idTUdmin="U1312" /TUdmin="-1804" /isTUend="FALSE" S_feature 1674154..1674258 /Source="Nicolas_S_feature" /locus_tag="new_1674154_1674258" /HighExp="G180, Oxctl, G150, G135, Paraq, LBGexp, H2O2, HPh, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S580" CDS 1674259..1674645 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389483.1" /db_xref="EnsemblGenomes-Gn:BSU16010" /db_xref="EnsemblGenomes-Tr:CAB13474" /db_xref="InterPro:IPR021297" /db_xref="SubtiList:BG13403" /db_xref="UniProtKB/Swiss-Prot:O31739" /translation="MQIIHRVAVMQVLTERSKEKLLASFAEKKQMLERECSQLYFQLR KHEKEQQNPNMIEQFKKAIEKRKDDIKIIDFQIAQVHTLPLGSELKEKEVDALLTIEA GDDWHEKTAANTIVIKDGKVIEIRQR*" gene 1674259..1674645 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" CDS 1674650..1675174 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15496525, 16014871, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="16S rRNA processing protein" /protein_id="NP_389484.1" /db_xref="EnsemblGenomes-Gn:BSU16020" /db_xref="EnsemblGenomes-Tr:CAB13475" /db_xref="GOA:O31740" /db_xref="InterPro:IPR002676" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR011961" /db_xref="InterPro:IPR027275" /db_xref="InterPro:IPR036976" /db_xref="SubtiList:BG13404" /db_xref="UniProtKB/Swiss-Prot:O31740" /translation="MTKRWFNVGKIVNTHGIKGEVRVISKTDFAEERYKPGNTLYLFM DGRNEPVEVTVNTHRLHKQFHLLQFKERQNLNEVEELKNAIIKVPEEELGELNEGEFY FHEIIGCEVFTEEGELIGKVKEILTPGANDVWVIGRKGKKDALIPYIESVVKHIDVRE KKIEIELMEGLIDE*" gene 1674650..1675174 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" CDS 1675171..1675902 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" /EC_number="2.1.1.228" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094308, 11532950, 12682299, 12773376, 15060037, 27881678, 28601227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(m1G37)methyltransferase" /protein_id="NP_389485.1" /db_xref="EnsemblGenomes-Gn:BSU16030" /db_xref="EnsemblGenomes-Tr:CAB13476" /db_xref="GOA:O31741" /db_xref="InterPro:IPR002649" /db_xref="InterPro:IPR016009" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG12687" /db_xref="UniProtKB/Swiss-Prot:O31741" /translation="MKIDFLTLFPEMFEGVLGSSILQKAQEKDAVQFQVVNFREYSDN KHNTVDDYPYGGGAGMVLKPQPVFDAVEDLTSKAAAAPRIILVCPQGERFTQKKAEQL AKEEHLLFICGHYEGYDERIREHLVTDEISIGDFVLTGGELPAMMIADSVVRLLPGVL GKEASHIEDSFSTGLLEHPHYTRPADYKGLKVPETLLSGNHAKIEEWRNKESIRRTYL RRPDLLKDHPLTEQQRKWISEWEKE*" gene 1675171..1675902 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" promotor_-35 1675908..1675915 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1675929..1675948 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1675933 /Source="Nicolas_upshifts" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" misc_RNA 1675981..1676022 /locus_tag="BSU_misc_RNA_30" /product="L19_leader" gene 1675981..1676022 /locus_tag="BSU_misc_RNA_30" CDS 1676042..1676389 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16272117, 27477481; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L19" /protein_id="NP_389486.2" /db_xref="EnsemblGenomes-Gn:BSU16040" /db_xref="EnsemblGenomes-Tr:CAB13477" /db_xref="GOA:O31742" /db_xref="InterPro:IPR001857" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR018257" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12667" /db_xref="UniProtKB/Swiss-Prot:O31742" /translation="MQKLIEDITKEQLRTDLPAFRPGDTLRVHVKVVEGNRERIQIFE GVVIKRRGGGISETFTVRKISYGVGVERTFPVHTPKIAKIEVVRYGKVRRAKLYYLRE LRGKAARIKEIRR*" gene 1676042..1676389 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" downshifts 1676391 /Source="Nicolas_upshifts" /id="D889" /incds=0 /nref=212 /ntot=274 /MaxReadThrough="6.00308" /MaxDrop="9.06015" /score="23.9942041" /energy="-12.6" /TU="U1313" /idTUdmin="U1312" /TUdmin=478 /isTUend="FALSE" promotor_-35 1676444..1676450 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1676463..1676531 /Source="Nicolas_S_feature" /locus_tag="new_1676463_1676531" /HighExp="Oxctl, G180, Paraq, G135, H2O2, LBGstat, dia15, G150, HPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.149563" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S581" upshifts 1676463 /Source="Nicolas_upshifts" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" promotor_-10 1676464..1676483 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1676532..1677380 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome biogenesis GTPase A" /protein_id="NP_389487.1" /db_xref="EnsemblGenomes-Gn:BSU16050" /db_xref="EnsemblGenomes-Tr:CAB13478" /db_xref="GOA:O31743" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016478" /db_xref="InterPro:IPR019991" /db_xref="InterPro:IPR023179" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="PDB:1PUJ" /db_xref="SubtiList:BG13405" /db_xref="UniProtKB/Swiss-Prot:O31743" /translation="MTIQWFPGHMAKARREVTEKLKLIDIVYELVDARIPMSSRNPMI EDILKNKPRIMLLNKADKADAAVTQQWKEHFENQGIRSLSINSVNGQGLNQIVPASKE ILQEKFDRMRAKGVKPRAIRALIIGIPNVGKSTLINRLAKKNIAKTGDRPGITTSQQW VKVGKELELLDTPGILWPKFEDELVGLRLAVTGAIKDSIINLQDVAVFGLRFLEEHYP ERLKERYGLDEIPEDIAELFDAIGEKRGCLMSGGLINYDKTTEVIIRDIRTEKFGRLS FEQPTM*" gene 1676532..1677380 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" promotor_-35 1677401..1677408 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1677421..1677439 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1677431 /Source="Nicolas_upshifts" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1677451..1678218 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" /EC_number="3.1.26.4" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10094689, 12475934, 23882084, 23937561, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094689, 12475934, 23882084, 23937561, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HII" /protein_id="NP_389488.1" /db_xref="EnsemblGenomes-Gn:BSU16060" /db_xref="EnsemblGenomes-Tr:CAB13479" /db_xref="GOA:O31744" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR022898" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12666" /db_xref="UniProtKB/Swiss-Prot:O31744" /translation="MNTLTVKDIKDRLQEVKDAQDPFIAQCENDPRKSVQTLVEQWLK KQAKEKALKEQWVNMTSYERLARNKGFRLIAGVDEVGRGPLAGPVVASAVILPEECEI LGLTDSKKLSEKKREEYYELIMKEALAVGIGIVEATVIDEINIYEASKMAMVKAIQDL SDTPDYLLVDAMTLPLDTAQASIIKGDAKSVSIAAGACIAKVTRDRMMSAYAETYPMY GFEKNKGYGTKEHLEALAAYGPTELHRKTFAPVQSFR*" gene 1677451..1678218 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" CDS 1678250..1679980 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389489.1" /db_xref="EnsemblGenomes-Gn:BSU16070" /db_xref="EnsemblGenomes-Tr:CAB13480" /db_xref="SubtiList:BG13406" /db_xref="UniProtKB/Swiss-Prot:O31745" /translation="MNIRNDVQKALQHLFGRTAVPQETSKVNEALNGEKRLLLGKVLR LLGDQHALIQVGNQTVQGKLETQLRPQAYYWFSYEKKTAEQTGRLQVVQSFDQNPKTI QDAAGKLLNAISVKTSNAALMMTGAMLKSKTPVTENDIKTAVRWMDTLPSQDTKKAVE TVLFALKRDLPIHSEILNGVHAVKSPVPLHQHVSQLLQAIDQNPQQSQMMSKLKEAVT VLLNSEIDVHAERLIDKLISLTDNTKAPSPTNTAGSRELSTPAGSPGKASLPIANHTA EQGSIQEEPVKTAADIPIKEARQLLVKLTESAEKNSLQIVKEAANWIKAAASSGDSKS LAASAVLQAAQVTDQEAEVFLKAVQQTAPHLADKADVLSFLSKVKTAIGARDEVAFIK AFEQGSAVTSGEMQSIKLALSALRASHEVAEPVKQEADQLFHKLNGQLFMQQDHPSYS QIVMSFPMFSKSGVQDMTVLFKGKKEADGKLDPSHCRLLFLLQLDTLKETVVDCLVQQ KVMTITIETDFELQAAIDPMVPALKQGLKEMGYSLSGVNAKKRVHTEEKASIDQYITS ISDQEVDVKI*" gene 1678250..1679980 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" upshifts complement(1679487) /Source="Nicolas_upshifts" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1679488..1679507) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1679522..1679529) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1679977..1680258 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative flagellar biosynthesis protein" /protein_id="NP_389490.1" /db_xref="EnsemblGenomes-Gn:BSU16080" /db_xref="EnsemblGenomes-Tr:CAB13481" /db_xref="GOA:O34867" /db_xref="InterPro:IPR004683" /db_xref="InterPro:IPR006135" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13407" /db_xref="UniProtKB/Swiss-Prot:O34867" /translation="MKEQTPIRKAVALHYDEQKDKAPRVIATGKGHVADNIIKEAKKA GVPIQEDRTLVELMRHLTVDDQIPEALYETVAEIFSFIYKLDESVKNKK*" gene 1679977..1680258 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" downshifts 1680090 /Source="Nicolas_upshifts" /id="D890" /incds=1 /nref=7 /ntot=136 /MaxReadThrough="4.03339" /MaxDrop="4.52065" /score="-6.81136789" /energy="-9.2" /TU="U1313,U1315" /idTUdmin="U1313" /TUdmin="-267" /isTUend="FALSE" S_feature 1680259..1680378 /Source="Nicolas_S_feature" /locus_tag="new_1680259_1680378" /HighExp="Cold, Lbstat, H2O2, Glu, Paraq, Mal, G135, GM 90, Oxctl, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S582" promotor_-35 1680350..1680357 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1680371..1680390 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1680380 /Source="Nicolas_upshifts" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1680431..1681588 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2548486, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (beta subunit)" /protein_id="NP_389491.1" /db_xref="EnsemblGenomes-Gn:BSU16090" /db_xref="EnsemblGenomes-Tr:CAB13482" /db_xref="GOA:P80886" /db_xref="InterPro:IPR005809" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013650" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017866" /db_xref="SubtiList:BG12680" /db_xref="UniProtKB/Swiss-Prot:P80886" /translation="MNIHEYQGKEVLRKYGVSVPEGKVAFTAEEAVESAKSLSSSVYV VKAQIHAGGRGKAGGVKIAKSLDEVKAYAEELLGKTLVTHQTGPDGQVIKRLLIEEGC DIKKEYYIGLVLDRATSRIVLMASEEGGTEIEEVAEKTPEKIKKAVIDPAVGLQGYQA REIAFAINIPKELVGKAAKFMLGLYKAFVEKDCSIAEINPLVVTGDGNVMALDAKLNF DSNALYRQKDIMEYRDLDEEDPKEIEASKYDLSYISLDGNIGCMVNGAGLAMSTMDII KHYGGEPANFLDVGGGATAEKVTEAFKIILSDQNVKGIFVNIFGGIMKCDVIAEGVVE ATRQVGLTLPLVVRLEGTNVDLGKKILSESGLNITSAESMADGAQKIVSLV*" gene 1680431..1681588 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" promotor_no_box complement(1680503..1680603) /Source="Nicolas_upshift_promotors" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1680543) /Source="Nicolas_upshifts" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1681617..1682519 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9643546, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (alpha subunit)" /protein_id="NP_389492.1" /db_xref="EnsemblGenomes-Gn:BSU16100" /db_xref="EnsemblGenomes-Tr:CAB13483" /db_xref="GOA:P80865" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR005810" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017440" /db_xref="InterPro:IPR033847" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12681" /db_xref="UniProtKB/Swiss-Prot:P80865" /translation="MSVFINKDTRVIVQGITGSTALFHTKQMLEYGTNIVGGVTPGKG GTEAEGVPVFNTVAEAVQTTGANASVIYVPAPFAADAIMEAVDAELDLVICITEHIPV LDMVKVKRFMEGKKTRLIGPNCPGVITPEECKIGIMPGYIHKKGHVGVVSRSGTLTYE AVHQLSEAGVGQSTAVGIGGDPVNGTNFIDVLKAFNEDPDTHAVIMIGEIGGTAEEEA AEWVKANMTKPVVGFIGGKTAPPGKRMGHAGAIISGGKGTADEKIKTLNACGIEVAET PSVMGETLIKVLKEKNLFETCKTH*" gene 1681617..1682519 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" downshifts 1682509 /Source="Nicolas_upshifts" /id="D891" /incds=0 /nref=94 /ntot=208 /MaxReadThrough="5.40077" /MaxDrop="4.8878" /score="9.51199539" /energy="-15" /TU="U1317" /idTUdmin="U1315" /TUdmin=2130 /isTUend="FALSE" CDS 1682580..1683473 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA processing Smf single strand binding protein" /protein_id="NP_389493.1" /db_xref="EnsemblGenomes-Gn:BSU16110" /db_xref="EnsemblGenomes-Tr:CAB13484" /db_xref="GOA:P39813" /db_xref="InterPro:IPR003488" /db_xref="SubtiList:BG11006" /db_xref="UniProtKB/Swiss-Prot:P39813" /translation="MDQAAVCLTICRINQLLSPSLLLKWWKADPSMSLTSPVLQTVTR DQIKAAALKNEIEQFYPKLPRVLAAYREQGINTIPISSKQYPFWLKSIYDPPAVLFAK GDMTLLSKGRKIGIVGTRNPTAYGKQVVNHLTKEICRKGWVIVSGLASGIDGMSHAAS IKAKGRTIGVIAGGFQHIYPRENLQLADHMAKHHILLSEHPPETKPQKWHFPMRNRII SGLSEGVIVVQGKEKSGSLITAYQALEQGREVFAVPGSLFDPYAGGPIKLIQQGAKAI WSAEDIFEELPERNVQYTEPF*" gene 1682580..1683473 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" promotor_-35 1683479..1683486 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1683501..1683520 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1683508..1683660 /Source="Nicolas_S_feature" /locus_tag="new_1683508_1683660" /HighExp="dia15, H2O2, G/S, Paraq, Diami, S1, Oxctl, LBGexp, C30, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.111279" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigD, SigA, SigA" /TUlongPSig="1, 1, 1" /label="S583" upshifts 1683508 /Source="Nicolas_upshifts" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1683661..1685736 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" /EC_number="5.99.1.2" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9580687, 12682299, 16585761, 23133654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9580687, 12682299, 16585761, 23133654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase I" /protein_id="NP_389494.1" /db_xref="EnsemblGenomes-Gn:BSU16120" /db_xref="EnsemblGenomes-Tr:CAB13485" /db_xref="GOA:P39814" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005733" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013498" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR028612" /db_xref="InterPro:IPR034149" /db_xref="SubtiList:BG11007" /db_xref="UniProtKB/Swiss-Prot:P39814" /translation="MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGV DIEQNFEPKYITIRGKGPVLKELKTAAKKAKKVYLAADPDREGEAIAWHLAHSLDLDL NSDCRVVFNEITKDAIKESFKHPRMINMDLVDAQQARRILDRLVGYKISPILWKKVKK GLSAGRVQSVALRLIIDREKEINDFKPEEYWTIDGTFLKGQETFEASFFGKNGKKLPL NSEADVKEILSQLKGNQYTVEKVTKKERKRNPALPFTTSTLQQEAARKLNFRAKKTMM IAQQLYEGIDLGREGTVGLITYMRTDSTRISNTAVDEAAAFIDQTYGKEFLGGKRKPA KKNENAQDAHEAIRPTSVLRKPSELKAVLGRDQMRLYKLIWERFVASQMAPAVLDTMS VDLTNNGLTFRANGSKVKFSGFMKVYVEGKDDQMEEKDRMLPDLQEGDTVLSKDIEPE QHFTQPPPRYTEARLVKTLEERGIGRPSTYAPTLDTIQRRGYVALDNKRFVPTELGQI VLDLIMEFFPEIINVEFTAKMERDLDHVEEGNTEWVKIIDNFYTDFEKRVKKAESEMK EVEIEPEYAGEDCELCSSPMVYKMGRYGKFLACSNFPDCRNTKPIVKQIGVKCPSCGE GNIVERKSKKKRVFYGCDRYPDCEFVSWDKPIERKCPKCGKMLVEKKLKKGIQVQCVE CDYKEEPQK*" gene 1683661..1685736 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" downshifts 1685706 /Source="Nicolas_upshifts" /id="D892" /incds=0 /nref=48 /ntot=173 /MaxReadThrough="5.66787" /MaxDrop="4.5486" /score="0.939045188" /energy="-13.2" /TU="U1319" /idTUdmin="U1317" /TUdmin="-19" /isTUend="TRUE" promotor_-35 1685768..1685773 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1685780 /Source="Nicolas_upshifts" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" promotor_-10 1685789..1685807 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1685812..1687119 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" /EC_number="2.1.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16027442, 21561081, 23095745, 23157377, 27825927, 28745052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16027442, 21561081, 23095745, 23157377, 27825927, 28745052; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA:m(5)U-54 methyltransferase" /protein_id="NP_389495.1" /db_xref="EnsemblGenomes-Gn:BSU16130" /db_xref="EnsemblGenomes-Tr:CAB13486" /db_xref="GOA:P39815" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004417" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11008" /db_xref="UniProtKB/Swiss-Prot:P39815" /translation="MNQQTVNVIGAGLAGSEAAWQLAKRGIQVKLYEMRPVKQTPAHH TDKFAELVCSNSLRSNTLANAVGVLKEEMRALDSAIIAAADECSVPAGGALAVDRHEF AASVTNRVKNHPNVTVINEEVTEIPEGPTIIATGPLTSESLSAQLKELTGEDYLYFYD AAAPIVEKDSLDMDKVYLKSRYDKGEAAYLNCPMTEEEFDRFHEALTSAETVPLKEFE KEIFFEGCMPIEVMAKRGKKTMLFGPMKPVGLEHPVTGKRPYAVVQLRQDDAAGTLYN IVGFQTHLKWGDQKEVLKLIPGLENVEIVRYGVMHRNTFINSPSLLKPTYQFKNRSDL FFAGQMTGVEGYVESAASGLVAGINAAKLVLGEELVIFPQETAIGSMAHYITTTNQKN FQPMNANFGLLKELPVKIKNKKERNEQYANRAIETIQTISKTI*" gene 1685812..1687119 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" promotor_-35 1687125..1687129 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1687146..1687165 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1687156 /Source="Nicolas_upshifts" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1687187..1688101 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" /function="16.9: Replicate" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11208805, 16553881, 16597952, 21239579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11208805, 16553881, 16597952, 21239579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_389496.1" /db_xref="EnsemblGenomes-Gn:BSU16140" /db_xref="EnsemblGenomes-Tr:CAB13487" /db_xref="GOA:P39776" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011931" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG10965" /db_xref="UniProtKB/Swiss-Prot:P39776" /translation="MENVKNFVKLFVEYLQIEKNYSQYTIVNYVDSIEEFETFLRVQG INGFEEAAYQDTRIFLTEAYEKGLSRRTISKKISALRSFYKFLMREKLIEENPFQLVH LPKQEKRIPKFLYQKELEELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITIND VDLFMDTVLVHGKGKKQRYIPFGSYAREALKVYMNSGRQCLLMKAKEPHDLLFVNQRG GPLTARGIRHILSGLVQKASSTLHIHPHMLRHTFATHLLNEGADLRSVQELLGHSNLS STQIYTHVSKEMLRNTYMSHHPRAFKKN*" gene 1687187..1688101 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" promotor_-35 1687226..1687230 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-35" upshifts 1687243 /Source="Nicolas_upshifts" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" promotor_-10 1687246..1687265 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-10" CDS 1688114..1688659 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" /EC_number="3.4.25.2" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (N-terminalserine protease)" /protein_id="NP_389497.1" /db_xref="EnsemblGenomes-Gn:BSU16150" /db_xref="EnsemblGenomes-Tr:CAB13488" /db_xref="GOA:P39070" /db_xref="InterPro:IPR001353" /db_xref="InterPro:IPR022281" /db_xref="InterPro:IPR023333" /db_xref="InterPro:IPR029055" /db_xref="PDB:1YYF" /db_xref="PDB:2Z3A" /db_xref="PDB:2Z3B" /db_xref="SubtiList:BG10966" /db_xref="UniProtKB/Swiss-Prot:P39070" /translation="MSSFHATTIFAVQHKGRSAMSGDGQVTFGQAVVMKHTARKVRKL FNGKVLAGFAGSVADAFTLFEKFEAKLEEYNGNLKRAAVELAKEWRSDKVLRKLEAML IVMNQDTLLLVSGTGEVIEPDDGILAIGSGGNYALAAGRALKKHAGESMSASEIARAA LETAGEICVYTNDQIILEELE*" gene 1688114..1688659 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" CDS 1688676..1690079 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (ATPase andchaperone)" /protein_id="NP_389498.1" /db_xref="EnsemblGenomes-Gn:BSU16160" /db_xref="EnsemblGenomes-Tr:CAB13489" /db_xref="GOA:P39778" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004491" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10967" /db_xref="UniProtKB/Swiss-Prot:P39778" /translation="MEKKPLTPRQIVDRLDQYIVGQQNAKKAVAVALRNRYRRSLLDE KLKDEVVPKNILMMGPTGVGKTEIARRIAKLSGAPFIKIEATKFTEVGYVGRDVESMV RDLVETSVRLIKEEKMNEVKEQAEENANKRIVRLLVPGKKKQSGVKNPFEMFFGGSQP NGEDEAESQEEANIEEKRKRMAHQLALGELEDYYVTVEVEEQQPSMFDMLQGSGMEQM GMNMQDALSGLMPKKKKRRKMTVREARKVLTNEEASKLIDMDEVGQEAVQRAEESGII FIDEIDKIAKNGGASSSADVSREGVQRDILPIVEGSTVVTKYGSVKTDHVLFIAAGAF HMAKPSDLIPELQGRFPIRVELNKLTVDDFVRILVEPDNALLKQYQALLQTEGISLEF SDEAIHKIAEVAYHVNQDTDNIGARRLHTILERLLEDLSFEAPDVTMEKITITPQYVE EKLGTIAKNKDLSQFIL*" gene 1688676..1690079 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" CDS 1690119..1690898 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, GTP and BCAA-dependent" /protein_id="NP_389499.1" /db_xref="EnsemblGenomes-Gn:BSU16170" /db_xref="EnsemblGenomes-Tr:CAB13490" /db_xref="GOA:P39779" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR013198" /db_xref="InterPro:IPR014154" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2B0L" /db_xref="PDB:2B18" /db_xref="PDB:2GX5" /db_xref="PDB:2HGV" /db_xref="PDB:5LNH" /db_xref="PDB:5LOE" /db_xref="PDB:5LOJ" /db_xref="PDB:5LOO" /db_xref="SubtiList:BG10968" /db_xref="UniProtKB/Swiss-Prot:P39779" /translation="MALLQKTRIINSMLQAAAGKPVNFKEMAETLRDVIDSNIFVVSR RGKLLGYSINQQIENDRMKKMLEDRQFPEEYTKNLFNVPETSSNLDINSEYTAFPVEN RDLFQAGLTTIVPIIGGGERLGTLILSRLQDQFNDDDLILAEYGATVVGMEILREKAE EIEEEARSKAVVQMAISSLSYSELEAIEHIFEELDGNEGLLVASKIADRVGITRSVIV NALRKLESAGVIESRSLGMKGTYIKVLNNKFLIELENLKSH*" gene 1690119..1690898 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" downshifts 1690873 /Source="Nicolas_upshifts" /id="D893" /incds=0 /nref=6 /ntot=130 /MaxReadThrough="5.35492" /MaxDrop="5.90286" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=0 /isTUend="TRUE" downshifts 1690917 /Source="Nicolas_upshifts" /id="D894" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="4.95658" /MaxDrop="4.85551" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=44 /isTUend="FALSE" promotor_-35 1691018..1691025 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1691038..1691056 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1691049..1691202 /Source="Nicolas_S_feature" /locus_tag="new_1691049_1691202" /HighExp="C30, GM 90, GM 25, Cold, GM 15, GM 10, MG 150, GM-0.2, LBGstat, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 0.994, 0.998" /TUlongSig="SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.999, 1, 1, 1" /label="S584" upshifts 1691049 /Source="Nicolas_upshifts" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" promotor_-35 1691177..1691184 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1691199..1691218 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1691204 /Source="Nicolas_upshifts" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1691278..1691667 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996, 17850253, 25843804; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389500.1" /db_xref="EnsemblGenomes-Gn:BSU16180" /db_xref="EnsemblGenomes-Tr:CAB13491" /db_xref="GOA:P24500" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006300" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10237" /db_xref="UniProtKB/Swiss-Prot:P24500" /translation="MSLFSGTIQNLENALSRADIKQKVITNNIANIDTPNYKAKKVSF QNLLDQESSRLEAIKTDYRHVDFSDTDSNYSIVASGDTSYQQNGNNVDVDKEMTELAQ NQINYQALVERMNGKFNSLKTVLTGGK*" gene 1691278..1691667 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" CDS 1691667..1692119 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389501.1" /db_xref="EnsemblGenomes-Gn:BSU16190" /db_xref="EnsemblGenomes-Tr:CAB13492" /db_xref="GOA:P24501" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006299" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10238" /db_xref="UniProtKB/Swiss-Prot:P24501" /translation="MTAFHSLNVSASALTAQRVRMDVVSSNLANMDTTRAKQVNGEWV PYRRKMVSLQSKGESFSSILNSQMSGSGNAGNGVKVSKITEDDSDFNLVYDPTDPDAN AEGYVQKPNVDPLKEMVDLVSSTRSYEANVTAMNATKGMLMKALEIGK*" gene 1691667..1692119 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" CDS 1692130..1692450 /gene="fliE" /locus_tag="BSU_16200" /old_locus_tag="BSU16200" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133968, 1551848, 1905667, 2544561, 9161424, 11133968, 15136044; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal body protein" /protein_id="NP_389502.1" /db_xref="EnsemblGenomes-Gn:BSU16200" /db_xref="EnsemblGenomes-Tr:CAB13493" /db_xref="GOA:P24502" /db_xref="InterPro:IPR001624" /db_xref="SubtiList:BG10239" /db_xref="UniProtKB/Swiss-Prot:P24502" /translation="MINAISPFQVQNTQNTQNATNQVNNSQKTDSSNQTSFSELLKNS ISSLNESQVASDNMTNALAAGKDVNLDEVMIAAQKASISLTAATEFRNKAVEAYQEIM RMQM*" gene 1692130..1692450 /gene="fliE" /locus_tag="BSU_16200" /old_locus_tag="BSU16200" downshifts complement(1692445) /Source="Nicolas_upshifts" /id="D895" /incds=0 /nref=1 /ntot=83 /MaxReadThrough="1.38909" /MaxDrop="2.66249" /score="0.0645368779" /energy="-7.4" /TU="NA" /idTUdmin="U1325" /TUdmin=2684 /isTUend="FALSE" CDS 1692496..1694106 /gene="fliF" /locus_tag="BSU_16210" /old_locus_tag="BSU16210" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1551848, 1905667, 2544561, 9161424, 11133968, 22670715, 24970213, 28089452; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal-body M-ring protein" /protein_id="NP_389503.1" /db_xref="EnsemblGenomes-Gn:BSU16210" /db_xref="EnsemblGenomes-Tr:CAB13494" /db_xref="GOA:P23447" /db_xref="InterPro:IPR000067" /db_xref="InterPro:IPR006182" /db_xref="InterPro:IPR013556" /db_xref="InterPro:IPR021157" /db_xref="SubtiList:BG10240" /db_xref="UniProtKB/Swiss-Prot:P23447" /translation="MNRTLMQMKNKTSEFWKNRSKLQKILMVSALAAIIIIGIIISVF ASNSKMAPLYKDLSAEEAGQIKEELDAKKVPNELSNGGTVISVPEDQVDSLKVQMAAE GLPKTGSIDYSFFGQNAGFGLTDNEFDMVKVKATQTELSNLINEMDGIKNSKVMINLP KDAVFVGEEQSAASASIVLQIQPGYTLDQSQINGLYHLVSKSVPNLKEDNIVIMDQNS TYYDKSDSDAGSYADSYSSQQGIKSQVEKDIQKHVQSLLGTMMGQDKVVVSVTADIDF TKENRTEDIVEPVDKENMEGIAVSAEKVSETYQGDGAANGGTAGTGEEDVTNYKADGE NTESGNYEKNSNKINYEVNRIHKEIAESPYKVRDLGIQVMVEPPDAKNTASLSTERQD DIQKILSTVVRTSLDKDETQNQNLSDADINNKIVVSVQPFDGKVNLDTNTEESSGIPL WAYIVGGVLIAAIIVLIIMLIRKKRAQEDEFEEYEYEVPQEPINLPDINEEENETAES VRRKQLEKMAKDKPEDFAKLLRSWLAED*" gene 1692496..1694106 /gene="fliF" /locus_tag="BSU_16210" /old_locus_tag="BSU16210" CDS 1694119..1695135 /gene="fliG" /locus_tag="BSU_16220" /old_locus_tag="BSU16220" /function="16.5: Explore" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1551848, 1905667, 2544561, 9161424, 10440379, 11133968, 28089452; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar motor switching and energizing component" /protein_id="NP_389504.1" /db_xref="EnsemblGenomes-Gn:BSU16220" /db_xref="EnsemblGenomes-Tr:CAB13495" /db_xref="GOA:P23448" /db_xref="InterPro:IPR000090" /db_xref="InterPro:IPR011002" /db_xref="InterPro:IPR023087" /db_xref="InterPro:IPR028263" /db_xref="InterPro:IPR032779" /db_xref="SubtiList:BG10241" /db_xref="UniProtKB/Swiss-Prot:P23448" /translation="MARRDQDKLTGKQKAAILMISLGLDVSASVYKHLTDEEIERLTL EISGVRSVDHQKKDEIIEEFHNIAIAQDYISQGGLSYARQVLEKALGEDKAENILNRL TSSLQVKPFDFARKAEPEQILNFIQQEHPQTMALILSYLDPVQAGQILSELNPEVQAE VARRIAVMDRTSPEIINEVERILEQKLSSAFTQDYTQTGGIEAVVEVLNGVDRGTEKT ILDSLEIQDPDLAEEIKKRMFVFEDIVTLDNRAIQRVIRDVENDDLLLSLKVASEEVK EIVFNNMSQRMVETFKEEMEFMGPVRLKDVEEAQSRIVSIVRKLEEAGEIVIARGGGD DIIV*" gene 1694119..1695135 /gene="fliG" /locus_tag="BSU_16220" /old_locus_tag="BSU16220" S_feature 1695136..1695253 /Source="Nicolas_S_feature" /locus_tag="new_1695136_1695253" /HighExp="Lbstat, C90, M0t90, M40t90, Lbtran, C30, LPhT, GM 90, M40t45, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigA" /TUshortPSig="0.998, 1, 0.998" /TUlongSig="SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.994, 1, 0.999, 1, 1, 1" /label="S585" promotor_no_box complement(1695199..1695299) /Source="Nicolas_upshift_promotors" /id="U1325" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.937062937062937" /psig="0.00999000999001" /xcortree=81 /SigmaFactorBS="ttgcctgctcagaaatccggtcagcttcctctttcactcggg ccataagcgcctccgggttctcttcagcctgcaaaaggtgagaatgatcaatacgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1695239) /Source="Nicolas_upshifts" /id="U1325" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.937062937062937" /psig="0.00999000999001" /xcortree=81 /SigmaFactorBS="ttgcctgctcagaaatccggtcagcttcctctttcactcggg ccataagcgcctccgggttctcttcagcctgcaaaaggtgagaatgatcaatacgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1695254..1695880 /gene="fliH" /locus_tag="BSU_16230" /old_locus_tag="BSU16230" /function="16.6: Maintain" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1828465, 12217691, 16522800, 17002279, 26916245; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar export apparatus subunit of cytoplasmic ATPase" /protein_id="NP_389505.2" /db_xref="EnsemblGenomes-Gn:BSU16230" /db_xref="EnsemblGenomes-Tr:CAB13496" /db_xref="GOA:P23449" /db_xref="InterPro:IPR018035" /db_xref="InterPro:IPR022524" /db_xref="SubtiList:BG10242" /db_xref="UniProtKB/Swiss-Prot:P23449" /translation="MARVKEEADRISEQANSHIENIRRQIEQEKNDWAAEKQKLIEEA KAEGFEQGVALGKAEAMKQYAELIGQANSITEMSRKAVEDKLEDANEEIVELAVALAK KVWQQKSDDKEAFLLLVQQVINEVKEYDDISIYVDPYYYETIFQQKDEIQQLLYKECR LGIYADEKAQKGTCYIETPFGRVDASVDTQLMQLKDKLLTALEAGAAE*" gene 1695254..1695880 /gene="fliH" /locus_tag="BSU_16230" /old_locus_tag="BSU16230" CDS 1695877..1697193 /gene="fliI" /locus_tag="BSU_16240" /old_locus_tag="BSU16240" /EC_number="3.6.3.14" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12787361, 16113269, 16780875, 17002279, 26916245; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="flagellar-specific ATPase subunit of export apparatus" /protein_id="NP_389506.2" /db_xref="EnsemblGenomes-Gn:BSU16240" /db_xref="EnsemblGenomes-Tr:CAB13497" /db_xref="GOA:P23445" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR000225" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005714" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR022425" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032463" /db_xref="SubtiList:BG10243" /db_xref="UniProtKB/Swiss-Prot:P23445" /translation="MKTQSLIDCIEMTDSYKRYGKVKRVIGLMIESKGPASSIGDLCL IYAKGQSGKVIKAEVVGFQEENILLMPYLEAASIAPGSIVEATGESLRVKVGTGLIGQ VIDAFGEPLDGKLLPKGLSPVSTEQSPPNPMKRPPIREKMGVGVRSIDSLLTVGKGQR IGIFAGSGVGKSTLMGMIAKQTEADLNVIALVGERGREVREFIEKDLGKEGLKRSIVV VATSDQPALMRLKAAYTATAIAEYFRDKGQNVMFMMDSVTRVAMAQREIGLAAGEPPT TKGYTPSVFAILPRLLERTGANEHGTITAFYTVLVDGDDMNEPIADTVRGILDGHIVL DRALANKGQFPAVNVLKSISRVMSNISTKQHLDAANKFRELLSTYQNSEDLINIGAYK RGSSREIDEAIQFYPQLIQFLKQGTDEPALLEESIAALTSLTGNEE*" gene 1695877..1697193 /gene="fliI" /locus_tag="BSU_16240" /old_locus_tag="BSU16240" CDS 1697196..1697639 /gene="fliJ" /locus_tag="BSU_16250" /old_locus_tag="BSU16250" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17088562, 26916245, 26984495, 27647891; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar synthesis rod subunit of export ATPase" /protein_id="NP_389507.1" /db_xref="EnsemblGenomes-Gn:BSU16250" /db_xref="EnsemblGenomes-Tr:CAB13498" /db_xref="GOA:P20487" /db_xref="InterPro:IPR012823" /db_xref="SubtiList:BG10245" /db_xref="UniProtKB/Swiss-Prot:P20487" /translation="MAYQFRFQKLLELKENEKDQSLSEYQQSVSEFENVAEKLYENMS KKELLEQNKEKKLKSGMSVQEMRHYQQFVSNLDNTIYHYQKLVIMKRNQMNQKQEILT EKNIEVKKFEKMREKQFKMFALEDKAAEMKEMDDISIKQFMIQGH*" gene 1697196..1697639 /gene="fliJ" /locus_tag="BSU_16250" /old_locus_tag="BSU16250" CDS 1697651..1698265 /gene="ylxF" /locus_tag="BSU_16260" /old_locus_tag="BSU16260" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17586671, 22307758; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative kinesin-like protein" /protein_id="NP_389508.2" /db_xref="EnsemblGenomes-Gn:BSU16260" /db_xref="EnsemblGenomes-Tr:CAB13499" /db_xref="GOA:P23454" /db_xref="InterPro:IPR006668" /db_xref="InterPro:IPR011002" /db_xref="SubtiList:BG10246" /db_xref="UniProtKB/Swiss-Prot:P23454" /translation="MSGKKKESGKFRSVLLIIILPLMFLLIAGGIVLWAAGINVLKPI QDAAAKTPVLKELVPETENKKGAASSKDSSNTAALEKTIKDQKSEISILNKDLETSKS EIDRLNQKIRSLEKTAEDQKKSSEDHTEGSADSKASSENDKVISVYKSMDSGKAAKII AQLKEQEALKILNGLSKKQLADILAKMTPEQAATYTEKIAASQE*" gene 1697651..1698265 /gene="ylxF" /locus_tag="BSU_16260" /old_locus_tag="BSU16260" CDS 1698278..1699741 /gene="fliK" /locus_tag="BSU_16270" /old_locus_tag="BSU16270" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16630628, 16949608, 28557186; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar hook-length control protein (ruler)" /protein_id="NP_389509.2" /db_xref="EnsemblGenomes-Gn:BSU16270" /db_xref="EnsemblGenomes-Tr:CAB13500" /db_xref="GOA:P23451" /db_xref="InterPro:IPR001635" /db_xref="InterPro:IPR021136" /db_xref="SubtiList:BG10247" /db_xref="UniProtKB/Swiss-Prot:P23451" /translation="MKLLELAGPLLQTTTGSAAKNMKSSQGVFQNWLMSEAGLKELSE QGKGTPNSEDQLLADALKKIGEWLNASPEDQDKQNADLLQTLSKLTGKQLDANALQML QNLLQAVESKMSGGTDQLLTETEKIFSEAKTALSANDSASDINGALKSDKEQSNQENE VSEPAKELIYIQMFISQLVEGNKLTDLGNGNEAHAIYQNGDQFLSALEKKGVSQQLIQ DLKQQIFTKAESSSKLYSMTASELKSFQSLMDQMSMLPQKGTKEWSLAESQLKAFLLS KSSESSQDFGKSVLTPLSQSSSSKNASDVSGSIQPVDSKSGLQMLFSGYRGIGGVQTL DLQQMSSDIPNAETKTVADQVINAWKQMKYTPFGRSTGSFTIRLNPEHLGFVTIKLTN ENGMFQSKIIASSQSAKELLEQHLPQLKQSLPNMAVQIDRFTLPVQSGDQPIYGQLAD EQKQQQEGQRQQRQKKQSNDFGDLLDEVSMVEMEEEE*" gene 1698278..1699741 /gene="fliK" /locus_tag="BSU_16270" /old_locus_tag="BSU16270" CDS 1699738..1700160 /gene="flgD" /locus_tag="BSU_16280" /old_locus_tag="BSU16280" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8157595, 14563871, 24748615; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar hook capping protein" /protein_id="NP_389510.1" /db_xref="EnsemblGenomes-Gn:BSU16280" /db_xref="EnsemblGenomes-Tr:CAB13501" /db_xref="GOA:P23455" /db_xref="InterPro:IPR005648" /db_xref="SubtiList:BG10248" /db_xref="UniProtKB/Swiss-Prot:P23455" /translation="MTSISSEYKLPEKTNTVSTNNSSLGKDEFLKILMTQVQNQDPLN PIDDKEFISQMATFSSLEQMMNLNTTMTQFVENQDPFTTYVDWMGKEVSWTDGKSATD KTGTVSSVKHFKGNYYLVLDDGTEISPANVMSVGQSSK*" gene 1699738..1700160 /gene="flgD" /locus_tag="BSU_16280" /old_locus_tag="BSU16280" CDS 1700182..1700976 /gene="flgE" /locus_tag="BSU_16290" /old_locus_tag="BSU16290" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15502333, 15510139, 27759043, 28120828, 28429800; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar hook protein" /protein_id="NP_389511.2" /db_xref="EnsemblGenomes-Gn:BSU16290" /db_xref="EnsemblGenomes-Tr:CAB13502" /db_xref="GOA:P23446" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR012836" /db_xref="InterPro:IPR019776" /db_xref="InterPro:IPR020013" /db_xref="SubtiList:BG10249" /db_xref="UniProtKB/Swiss-Prot:P23446" /translation="MLRSLYSGISGMKNFQTKLDVIGNNIANVNTVGFKKSRVTFKDM VSQTIAGGSAAGATIGGTNSKQIGLGSSSGTIDTIHSTSATQSTGRTLDLAIDGDGYF RIDTGDGTAYTRAGNFYLDNTGTLVTGDGYHVLNMNGGTIKIPTDAQSFSIGSDGKVS IVDAEGKTQDGGQIGIVTFANSDGLDKIGSNLYRESLNSGTASAANQPGDGGTGALKS GFLEMSNVDLTDEFTEMIVAQRGFQSNSKIITTSDEILQELVNLKR*" gene 1700182..1700976 /gene="flgE" /locus_tag="BSU_16290" /old_locus_tag="BSU16290" CDS 1701016..1701231 /gene="swrD" /locus_tag="BSU_16299" /old_locus_tag="BSU16299" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9168127, 29061663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9168127, 29061663; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar power transducer required for swarming" /protein_id="YP_003097728.1" /db_xref="EnsemblGenomes-Gn:BSU16299" /db_xref="EnsemblGenomes-Tr:CAX52619" /db_xref="InterPro:IPR009384" /db_xref="UniProtKB/Swiss-Prot:C0H412" /translation="MIKVTRLNGQPFTLNALFIEQIECFPDTTITLSNGKKFVVKEDE EAVLEKIAAFYRKIQIFAMDQGIEEPE*" gene 1701016..1701231 /gene="swrD" /locus_tag="BSU_16299" /old_locus_tag="BSU16299" CDS 1701228..1701650 /gene="fliL" /locus_tag="BSU_16300" /old_locus_tag="BSU16300" /function="16.5: Explore" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10439416, 12787361, 16166542, 23264580, 25714720, 28717192; Product type f : factor" /codon_start=1 /transl_table=11 /product="flagellar basal-body (stator) associated protein" /protein_id="NP_389512.1" /db_xref="EnsemblGenomes-Gn:BSU16300" /db_xref="EnsemblGenomes-Tr:CAB13503" /db_xref="GOA:P23452" /db_xref="InterPro:IPR005503" /db_xref="SubtiList:BG10250" /db_xref="UniProtKB/Swiss-Prot:P23452" /translation="MKKKLMIILLIILIVIGALGAAAYFVLGGKSEKSEAKKSIDEIV ASSVDVEEITTNLKSDNIIRLAIKLETDSDKSKEELEKRDFQVKDAVISLLADTNADQ IEGDKGKETFKKELKDKINSYLQEGKVEKVYITSFNLQ*" gene 1701228..1701650 /gene="fliL" /locus_tag="BSU_16300" /old_locus_tag="BSU16300" CDS 1701684..1702682 /gene="fliM" /locus_tag="BSU_16310" /old_locus_tag="BSU16310" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7787061, 16547037, 16796690, 16882724, 17015643, 17050923, 22720735, 28625846; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="flagellar motor switching and energizing component" /protein_id="NP_389513.1" /db_xref="EnsemblGenomes-Gn:BSU16310" /db_xref="EnsemblGenomes-Tr:CAB13504" /db_xref="GOA:P23453" /db_xref="InterPro:IPR001543" /db_xref="InterPro:IPR001689" /db_xref="InterPro:IPR028976" /db_xref="InterPro:IPR036429" /db_xref="SubtiList:BG10251" /db_xref="UniProtKB/Swiss-Prot:P23453" /translation="MSGEVLSQNEIDALLSAISTGEMDAEELKKEEKEKKVKVYDFKR ALRFSKDQIRSLTRIHDNFARLLTTHFSAQLRTYIHISVSSVDQVPYEEFIRSIPNMT ILNLFDVHPMEGRIMMEVNPTIAYTMMDRVMGGIGISHNKVDSLTEIETKIISNLFEN ALGNYKEAWQSIADIEPEMTEFEVNPQFVQMVSPNETVVVISLNTQIGEISGVINLCI PHIVLEPLIPKLSVHYWMQSDRNEPKPEETKSLEKRIMTAQIPVVAELGTSELTIEEF LSLEVGDCITLDKSVTDPLTVLVGDKPKFLGQAGRVNRKQAVQILDHDIRGEQDGE*" gene 1701684..1702682 /gene="fliM" /locus_tag="BSU_16310" /old_locus_tag="BSU16310" CDS 1702672..1703808 /gene="fliY" /locus_tag="BSU_16320" /old_locus_tag="BSU16320" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12920116, 16547037, 16796690, 16882724, 17015643, 17050923, 23226535, 23532838, 26195616" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12920116, 16547037, 16796690, 16882724, 17015643, 17050923, 23226535, 23532838, 26195616; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="flagellar motor switching and energizing phosphatase" /protein_id="NP_389514.1" /db_xref="EnsemblGenomes-Gn:BSU16320" /db_xref="EnsemblGenomes-Tr:CAB13505" /db_xref="GOA:P24073" /db_xref="InterPro:IPR001172" /db_xref="InterPro:IPR001543" /db_xref="InterPro:IPR007597" /db_xref="InterPro:IPR012826" /db_xref="InterPro:IPR028976" /db_xref="InterPro:IPR036429" /db_xref="SubtiList:BG10252" /db_xref="UniProtKB/Swiss-Prot:P24073" /translation="MENNRLSQDEIDALLNGTGSTLDEPEIPEVDDLSEMERDAIGEI GNISFGSSATALSTLLNQKVDITTPSVTVIPRSKISDAFPEPYVAIEVNYTEGFSGSN LLVVEQSDAAIIADLMIGGDGKGADPSLGEIHLSAVQEAMNQMMGSAATSMSTVFSKK IDISPPRVELLDVTEEKGTDRIPDDEMLVKVSFNLKVGELIDSSIMQLYPLTFAKDLI SSLMNSESAEEEETVQPEVTYEQPKEPVTPEPRIEPKQQQQPPKRQGTAKKAAPVQVS PVEFSAFDPNEAVQAPIHNLDMLLDIPLSITVELGRTKRSVKEILELSAGSIIELDKL AGEPVDILVNQRIVAKGEVVVIEENFGVRVTDILSQAERINNLK*" gene 1702672..1703808 /gene="fliY" /locus_tag="BSU_16320" /old_locus_tag="BSU16320" CDS 1703834..1704196 /gene="cheY" /locus_tag="BSU_16330" /old_locus_tag="BSU16330" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10196193, 12864845, 12920116, 14749334, 23226535, 28542702" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10196193, 12864845, 12920116, 14749334, 23226535, 28542702; Product type r : regulator" /codon_start=1 /transl_table=11 /product="regulator of chemotaxis and motility" /protein_id="NP_389515.1" /db_xref="EnsemblGenomes-Gn:BSU16330" /db_xref="EnsemblGenomes-Tr:CAB13506" /db_xref="GOA:P24072" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG10258" /db_xref="UniProtKB/Swiss-Prot:P24072" /translation="MAHRILIVDDAAFMRMMIKDILVKNGFEVVAEAENGAQAVEKYK EHSPDLVTMDITMPEMDGITALKEIKQIDAQARIIMCSAMGQQSMVIDAIQAGAKDFI VKPFQADRVLEAINKTLN*" gene 1703834..1704196 /gene="cheY" /locus_tag="BSU_16330" /old_locus_tag="BSU16330" CDS 1704211..1704870 /gene="fliZ" /locus_tag="BSU_16340" /old_locus_tag="BSU16340" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10791024, 1597417, 16513753, 24204316; Product type r: regulator" /codon_start=1 /transl_table=11 /product="flagellar regulatory protein" /protein_id="NP_389516.1" /db_xref="EnsemblGenomes-Gn:BSU16340" /db_xref="EnsemblGenomes-Tr:CAB13507" /db_xref="GOA:P35536" /db_xref="InterPro:IPR022781" /db_xref="SubtiList:BG10259" /db_xref="UniProtKB/Swiss-Prot:P35536" /translation="MKKSQYFIVFICFFVLFSVHPIAAAAADSDNSTVNEWFQKKDEK TADQSEQKKEKTTKTADETEGAAAPSVSAFDFVKMIFALLFVIVLIYGLVKLMNKRNR LLKPFQYVENIGGTSVGQNRSIQLIKVGKSVLVVGVGETIQLLKEIEDEKEIEVILSQ HEEAMSSKIEWQKFVKPLKSSEHQPQQKLPSFSKALKEQLEELKQNRSEGKKKGPRHH E*" gene 1704211..1704870 /gene="fliZ" /locus_tag="BSU_16340" /old_locus_tag="BSU16340" CDS 1704863..1705528 /gene="fliP" /locus_tag="BSU_16350" /old_locus_tag="BSU16350" /function="16.3: Control" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15516571, 15849754, 16850406, 22720735, 26244495, 27855178, 28559296; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389517.1" /db_xref="EnsemblGenomes-Gn:BSU16350" /db_xref="EnsemblGenomes-Tr:CAB13508" /db_xref="GOA:P35528" /db_xref="InterPro:IPR005837" /db_xref="InterPro:IPR005838" /db_xref="SubtiList:BG10260" /db_xref="UniProtKB/Swiss-Prot:P35528" /translation="MNEFINIFSSSDPENVSSTVKLLLLLTVFSVAPGILILMTCFTR IVIVLSFVRTSLATQSMPPNQVLIGLALFLTFFIMAPTFSEINKEALTPLMDNKISLD EAYTKAEEPIKEFMSKHTRQKDLALFMNYAKMDKPESLKDIPLTTMVPAFAISELKTA FQIGFMIFIPFLIIDMVVASVLMSMGMMMLPPVMISLPFKILLFVLVDGWYLIVKSLL QSF*" gene 1704863..1705528 /gene="fliP" /locus_tag="BSU_16350" /old_locus_tag="BSU16350" CDS 1705543..1705812 /gene="fliQ" /locus_tag="BSU_16360" /old_locus_tag="BSU16360" /function="16.5: Explore" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10234819, 15516571, 27855178; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389518.1" /db_xref="EnsemblGenomes-Gn:BSU16360" /db_xref="EnsemblGenomes-Tr:CAB13509" /db_xref="GOA:P35535" /db_xref="InterPro:IPR002191" /db_xref="InterPro:IPR006305" /db_xref="SubtiList:BG10261" /db_xref="UniProtKB/Swiss-Prot:P35535" /translation="MSSEFVISMAEKAVYVTLMISGPLLAIALLVGLIVSIFQATTQI QEQTLAFIPKIVAVLLALIFFGPWMLSTILSFTTELFSNLNRFAG*" gene 1705543..1705812 /gene="fliQ" /locus_tag="BSU_16360" /old_locus_tag="BSU16360" CDS 1705820..1706599 /gene="fliR" /locus_tag="BSU_16370" /old_locus_tag="BSU16370" /function="16.5: Explore" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15060055, 15516571, 15849754, 16850406, 28771474; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389519.2" /db_xref="EnsemblGenomes-Gn:BSU16370" /db_xref="EnsemblGenomes-Tr:CAB13510" /db_xref="GOA:P35537" /db_xref="InterPro:IPR002010" /db_xref="InterPro:IPR006303" /db_xref="SubtiList:BG10262" /db_xref="UniProtKB/Swiss-Prot:P35537" /translation="MNSIIDLFPAFLLVFIRISAFFVTIPLFGHRNVPAVHRIGFAFF LAVICFSTIDKPPSLEIDEHYMLLAFKEALVGLCLGLIAYMMIAAVQIAGSFIDFQMG FSIANVIDPQTGAQSPLIGQFIYTMALLFMLSVNAHHLLLDGIYYSFQYISVDQAFPN FGDEKFAYFIAKSFNAMFIIAFQMSAPVVASLFLVDLALGIVARTVPQLNVFVVGLPL KIAVSFIMLIVCMSVIFVVVRNVFSLTIETMRNLLALVGVS*" gene 1705820..1706599 /gene="fliR" /locus_tag="BSU_16370" /old_locus_tag="BSU16370" CDS 1706599..1707681 /gene="flhB" /locus_tag="BSU_16380" /old_locus_tag="BSU16380" /function="16.1: Circulate" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10234819, 16949608, 17050924, 17067800, 28557186, 28771466; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389520.1" /db_xref="EnsemblGenomes-Gn:BSU16380" /db_xref="EnsemblGenomes-Tr:CAB13511" /db_xref="GOA:P35538" /db_xref="InterPro:IPR006135" /db_xref="InterPro:IPR006136" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG10543" /db_xref="UniProtKB/Swiss-Prot:P35538" /translation="MKLRVDLQFFAGEKTEKATPKKRKDTRKKGQVAKSSDVNTAVSL LVIFLSLIAIGPYMRDRLLSFIETFYTESLTMKLSESNVHTLFVSLLKDMGMILAPIL LVALVAGVVSNYMQVGFLFSAEVIQPKLEKLDPIKGFKRIYSMRAIVELIKSILKIVV VGFAAFAVLWLHYGEILRLPLLTPEEALSFVSKLTLWMGLSGAGALLILAGLDYLYQR FDYEKNIKMSKQDIKDEYKKSEGDPIIKSKIKQRQREMAMRRMMQEVPKADVIITNPT HYAIALKYDEEKMDAPYIVAKGVDHLALKIRKIAKEHDVMMVENRPLARALYDQVEID QAVPEEFFKVLAEILAYVYKTKQKVY*" gene 1706599..1707681 /gene="flhB" /locus_tag="BSU_16380" /old_locus_tag="BSU16380" CDS 1707714..1709747 /gene="flhA" /locus_tag="BSU_16390" /old_locus_tag="BSU16390" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10234819, 15516571, 20534509, 28771466" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10234819, 15516571, 20534509, 28771466; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389521.2" /db_xref="EnsemblGenomes-Gn:BSU16390" /db_xref="EnsemblGenomes-Tr:CAB13512" /db_xref="GOA:P35620" /db_xref="InterPro:IPR001712" /db_xref="InterPro:IPR006301" /db_xref="InterPro:IPR025505" /db_xref="PDB:3MIX" /db_xref="SubtiList:BG10542" /db_xref="UniProtKB/Swiss-Prot:P35620" /translation="MSTRDLSVLISVVLIVAMLVIPFPPWLLSILIIINISLALIVLL TTMNMQEALQFSIFPSLLLLLTLFRLGLNVSTTRSILSHGEGGKVVETFGNFVVGGNV LVGLVVFIILIIIQFIVITKGAERVSEVAARFTLDAMPGKQMSIDADLNAGMITEQEA KHRREKVAREADFYGAMDGASKFVKGDAIAGIIIVMINIIFGIVIGMLQQGMSIQEAA SHFTMLTVGDGIVSQIPALLISTATGIVVTRAASEGNLGHDITGQLFAYPKLLYVAAA TIMLLGIFTPIGILLTGPLAGLLAFGAYTLSKSGKEKEEVDEILEEEAEVDELKSPES VVQLLHIDPIEFEFGYGLIPLADANQGGDLLDRIVMIRRQLALELGLVIPVVRIRDNI ALQPNEYRLKIKGNEVAKGELLLDHYLAMSPTPEDDLIEGIETVEPSFGLPAKWISEA VKDEADMLGYTVVDPASVVSTHITEKIKQHAHELIGRQETKQLIDHLKESYPVLVEEV TPNPLSVGDIQKVLAKLLKEKVSIRNLVTIFETLADYGKLTTDSDLLTEYTRQALAKQ ITAQFAKENEVLKVVTCSGRVEKAIADGVQQTEHGNYLSLEPDISESIVRSVAKEAEQ LSLRQETAILLCSPPVRMYVKQLLERYFPDLPVLSYNELEANVEVQSIGVVDI*" gene 1707714..1709747 /gene="flhA" /locus_tag="BSU_16390" /old_locus_tag="BSU16390" CDS 1709747..1710847 /gene="flhF" /locus_tag="BSU_16400" /old_locus_tag="BSU16400" /function="16.5: Explore" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1447978, 15317803, 16980502, 17565194, 17699634, 26195616, 27807433; Product type t: transporter" /codon_start=1 /transl_table=11 /product="GTPase involved in the export of flagella and number regulation" /protein_id="NP_389522.1" /db_xref="EnsemblGenomes-Gn:BSU16400" /db_xref="EnsemblGenomes-Tr:CAB13513" /db_xref="GOA:Q01960" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR020006" /db_xref="InterPro:IPR027417" /db_xref="PDB:2PX0" /db_xref="PDB:2PX3" /db_xref="PDB:3SYN" /db_xref="SubtiList:BG10544" /db_xref="UniProtKB/Swiss-Prot:Q01960" /translation="MKIKKFTAASMQEAALLIRKELGNEAVILNSKKIKKRKWFGLVN KPAVEVIAVLDQDFLEKKTPQKAAEPKQTLKTPVSSPKIEERTYPPQIPAQQELGDFS AYQSVLPEPLRKAEKLLQETGIKESTKTNTLKKLLRFSVEAGGLTEENVVGKLQEILC DMLPSADKWQEPIHSKYIVLFGSTGAGKTTTLAKLAAISMLEKHKKIAFITTDTYRIA AVEQLKTYAELLQAPLEVCYTKEEFQQAKELFSEYDHVFVDTAGRNFKDPQYIDELKE TIPFESSIQSFLVLSATAKYEDMKHIVKRFSSVPVNQYIFTKIDETTSLGSVFNILAE SKIGVGFMTNGQNVPEDIQTVSPLGFVRMLCR*" gene 1709747..1710847 /gene="flhF" /locus_tag="BSU_16400" /old_locus_tag="BSU16400" promotor_-10 complement(1710724..1710743) /Source="Nicolas_upshift_promotors" /id="U1326" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1367 /SigmaFactorBS="gcacattctggccgttagtcataaaCCCGACACCTatttttg attctgCCAGTATATTAAATACAGAAcctaaggaagtcgtttcatctattttcgtaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1710731) /Source="Nicolas_upshifts" /id="U1326" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1367 /SigmaFactorBS="gcacattctggccgttagtcataaaCCCGACACCTatttttg attctgCCAGTATATTAAATACAGAAcctaaggaagtcgtttcatctattttcgtaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1710757..1710766) /Source="Nicolas_upshift_promotors" /id="U1326" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1367 /SigmaFactorBS="gcacattctggccgttagtcataaaCCCGACACCTatttttg attctgCCAGTATATTAAATACAGAAcctaaggaagtcgtttcatctattttcgtaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1710838..1711734 /gene="flhG" /locus_tag="BSU_16410" /old_locus_tag="BSU16410" /function="16.5: Explore" /function="16.6: Maintain" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15361076, 25733861, 26411371" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15361076, 25733861, 26411371; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATPase affecting flagellar basal body localisation and number" /protein_id="NP_389523.1" /db_xref="EnsemblGenomes-Gn:BSU16410" /db_xref="EnsemblGenomes-Tr:CAB13514" /db_xref="GOA:P40742" /db_xref="InterPro:IPR025501" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033756" /db_xref="InterPro:IPR033875" /db_xref="PDB:3SYN" /db_xref="SubtiList:BG10254" /db_xref="UniProtKB/Swiss-Prot:P40742" /translation="MQMNRYDQAATLRAKMEKRERVLPMVYSQKAKTLAVISGKGGVG KSNITLNMALALQDKGKKVLLIDLDIGMGNIDILIGNSSSATIIDVLTDRKPLLQSLS VGPKGLRYISGGTGLDVMFQLDQRKWTFFANELSHALSQFDYVLFDMGAGLSKDQLPF ILSAEDILIITTPEPTAIMDAYSAVKHLVLTENKLSMKVAVNRCRDQKEGLDAFARLS RTIHMFLDVQVQFAGSVSDDVIVSKAVVEQVPFFIKSPQAKASRSVRILADALFEREE TRHKEDKQTFIEKLSSFLMRRA*" gene 1710838..1711734 /gene="flhG" /locus_tag="BSU_16410" /old_locus_tag="BSU16410" CDS 1711736..1712809 /gene="cheB" /locus_tag="BSU_16420" /old_locus_tag="BSU16420" /EC_number="3.1.1.61" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1738311, 10632876, 12123464, 21515776" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1738311, 10632876, 12123464, 21515776; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis proteins (MCP)-glutamate methylesterase" /protein_id="NP_389524.2" /db_xref="EnsemblGenomes-Gn:BSU16420" /db_xref="EnsemblGenomes-Tr:CAB13515" /db_xref="GOA:Q05522" /db_xref="InterPro:IPR000673" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR008248" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR035909" /db_xref="SubtiList:BG10255" /db_xref="UniProtKB/Swiss-Prot:Q05522" /translation="MIRVLVVDDSAFMRKMISDFLTEEKQIEVIGTARNGEEALKKIE LLKPDVITLDVEMPVMNGTDTLRKIIEIYNLPVIMVSSQTEKGKECTINCLEIGAFDF ITKPSGSISLDLYKIKEQLVERVVAAGLSGKRKRPVSQTVRPEPIVRAVVKPELSKPK PGTGRQIVCIGTSTGGPRALQKVIPKLPKDLNAPVVVVQHMPEGFTASLADRLNHLSD IQVKEAKDGEAALNGCVYIAPGGKNISVIKNSEGLQVVLDNHDTPSRHKPSADYLFRS VGKLTDYEKVAVIMTGMGSDGTAGLKDMLTAGNVKAIAESEESCVVYGMPKAAVKAGL IHEIKHVEDIAASITSCVKKERV*" gene 1711736..1712809 /gene="cheB" /locus_tag="BSU_16420" /old_locus_tag="BSU16420" CDS 1712815..1714833 /gene="cheA" /locus_tag="BSU_16430" /old_locus_tag="BSU16430" /EC_number="2.7.3.-" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:12094812, 12864845, 12920116, 15451661, 16045621, 21515776, 22355139" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12094812, 12864845, 12920116, 15451661, 16045621, 21515776, 22355139; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="chemotactic two-component sensor histidine kinase" /protein_id="NP_389525.2" /db_xref="EnsemblGenomes-Gn:BSU16430" /db_xref="EnsemblGenomes-Tr:CAB13516" /db_xref="GOA:P29072" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004105" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR008207" /db_xref="InterPro:IPR010808" /db_xref="InterPro:IPR035891" /db_xref="InterPro:IPR036061" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036641" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037006" /db_xref="InterPro:IPR037052" /db_xref="SubtiList:BG10256" /db_xref="UniProtKB/Swiss-Prot:P29072" /translation="MDMNQYLDVFIDESKEHLQTCNEKLLLLEKDPTDLQLVHDIFRA AHTLKGMSATMGYTDLAHLTHLLENVLDAIRNGDMEVTSDWLDILFEALDHLETMVQS IIDGGDGKRDISEVSAKLDVNGAHAESAASAEPAEAQSSASDWEYDEFERTVIQEAEE QGFKRYEIKISLNENCMLKAVRVYMVFEKLNEVGEVAKTIPSAEVLETEDFGTDFQVC FLTHQSAEDIEQLINGVSEIEHVEVIQGAPLTSAEKPEESKQEDSPAAAVPAKQEKQK QPAKNDEQAKHSAGGSKTIRVNIDRLDSLMNLFEELVIDRGRLEQIAKELEHNELTET VERMTRISGDLQSIILNMRMVPVETVFNRFPRMIRQLQKELNKKIELSIIGAETELDR TVIDEIGDPLVHLIRNSIDHGIEAPETRLQKGKPESGKVVLKAYHSGNHVFIEVEDDG AGLNRKKILEKALERGVITEKEAETLEDNQIYELIFAPGFSTADQISDISGRGVGLDV VKNKLESLGGSVSVKSAEGQGSLFSIQLPLTLSIISVLLIKLEEETFAIPISSIIETA VIDRKDILQTHDREVIDFRGHIVPVVYLKEEFKIEDTRKDAEQLHIIVVKKGDKPTAF VVDSFIGQQEVVLKSLGDYLTNVFAISGATILGDGEVALIIDCNALII*" gene 1712815..1714833 /gene="cheA" /locus_tag="BSU_16430" /old_locus_tag="BSU16430" CDS 1714855..1715325 /gene="cheW" /locus_tag="BSU_16440" /old_locus_tag="BSU16440" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12864845, 15451661, 1624415, 8169223, 8169224" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12864845, 15451661, 1624415, 8169223, 8169224; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulation of CheA activity in response to attractants (chemotaxis)" /protein_id="NP_389526.1" /db_xref="EnsemblGenomes-Gn:BSU16440" /db_xref="EnsemblGenomes-Tr:CAB13517" /db_xref="GOA:P39802" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR036061" /db_xref="SubtiList:BG10692" /db_xref="UniProtKB/Swiss-Prot:P39802" /translation="MTAEIKTGEKMIVFMVNGKEYAISVTQVKSIEKWQKPTRVPGVE PYICGVINLRGVVTPVIDLRKRLNLPEYEITDETRIIIIAYRDIEVGWIVDEANDVIT VHESEIESAPEGVQKDTDVSIEQIVKQENRLLNIIDANAVLDKESSQSAVPDQA*" gene 1714855..1715325 /gene="cheW" /locus_tag="BSU_16440" /old_locus_tag="BSU16440" CDS 1715344..1715973 /gene="cheC" /locus_tag="BSU_16450" /old_locus_tag="BSU16450" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12920116, 14749334, 14993307, 15546616, 16469702, 18990184, 22720735, 23226535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12920116, 14749334, 14993307, 15546616, 16469702, 18990184, 22720735, 23226535; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="signal terminating phosphatase of CheR-mediated methylation of methyl-accepting chemotaxis proteins (MCPs)" /protein_id="NP_389527.1" /db_xref="EnsemblGenomes-Gn:BSU16450" /db_xref="EnsemblGenomes-Tr:CAB13518" /db_xref="GOA:P40403" /db_xref="InterPro:IPR007597" /db_xref="InterPro:IPR028976" /db_xref="SubtiList:BG10749" /db_xref="UniProtKB/Swiss-Prot:P40403" /translation="MSIFNGIKEEQMDILREVGNIGAGHSASAMAQLLNRKIDMEVPF AKLLSFDELVDFFGGADVPVASIFLRMEGDLTGSMFFIMPFFQAEQFIRELIGNPDFD IEDLGEDHMSSSALHELGNILAGSYLTALADLTKLQLYPSVPEVSLDMFGAVISEGLM ELSQVGEHAIVVDTSIFDQSHQQELKAHMFMLPDYDSFEKLFVALGASL*" gene 1715344..1715973 /gene="cheC" /locus_tag="BSU_16450" /old_locus_tag="BSU16450" CDS 1715970..1716470 /gene="cheD" /locus_tag="BSU_16460" /old_locus_tag="BSU16460" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15546616, 16469702, 22720735, 23226535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15546616, 16469702, 22720735, 23226535; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sequence specific deamidase required for methylation of methyl-accepting chemotaxis proteins (MCPs) by CheR" /protein_id="NP_389528.1" /db_xref="EnsemblGenomes-Gn:BSU16460" /db_xref="EnsemblGenomes-Tr:CAB13519" /db_xref="GOA:P40404" /db_xref="InterPro:IPR005659" /db_xref="InterPro:IPR011324" /db_xref="SubtiList:BG10750" /db_xref="UniProtKB/Swiss-Prot:P40404" /translation="MSTTEAVVIKVGIADVKIARFPDTIRTSGLGSCVGLVLYDKEKQ TAGLVHVMLPDSTLSKTAELNRAKYADTAVQTTIDMLIEAGCRKFALKAKLAGGSEMF KFKSTNDLMKIGPRNVLAIKEQLSLFNIPIISEDTGGSSGRTIEFEPKSCMLHIRTVK QGEKTI*" gene 1715970..1716470 /gene="cheD" /locus_tag="BSU_16460" /old_locus_tag="BSU16460" CDS 1716493..1717257 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-28 factor (sigma-D)" /protein_id="NP_389529.1" /db_xref="EnsemblGenomes-Gn:BSU16470" /db_xref="EnsemblGenomes-Tr:CAB13520" /db_xref="GOA:P10726" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR012845" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10751" /db_xref="UniProtKB/Swiss-Prot:P10726" /translation="MQSLNYEDQVLWTRWKEWKDPKAGDDLMRRYMPLVTYHVGRISV GLPKSVHKDDLMSLGMLGLYDALEKFDPSRDLKFDTYASFRIRGAIIDGLRKEDWLPR TSREKTKKVEAAIEKLEQRYLRNVSPAEIAEELGMTVQDVVSTMNEGFFANLLSIDEK LHDQDDGENIQVMIRDDKNVPPEEKIMKDELIAQLAEKIHELSEKEQLVVSLFYKEEL TLTEIGQVLNLSTSRISQIHSKALFKLKNLLEKVIQ*" gene 1716493..1717257 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" promotor_-35 1717267..1717273 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" CDS 1717286..1717789 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15066026, 15175317, 19202088, 21736639, 26244495" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 15175317, 19202088, 21736639, 26244495; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling factor for flagellin transcription and translation" /protein_id="NP_389530.1" /db_xref="EnsemblGenomes-Gn:BSU16480" /db_xref="EnsemblGenomes-Tr:CAB13521" /db_xref="SubtiList:BG10752" /db_xref="UniProtKB/Swiss-Prot:P40405" /translation="MSTLLWLLSFMLHGVLLYAVIILYTRLAAVKETEKQQKQILEET ENTLAAFLLELKEENEKLIENKASSASQSDEESQKSGLQTSETYQERDPVQEAENLPE HIEGLITEVDRREELVNSEVQSFEDQVIELYEQGYSASQIAQKMKSGKTEIELFLKFR SKGVKDS*" gene 1717286..1717789 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" promotor_-10 1717288..1717299 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1717302 /Source="Nicolas_upshifts" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" promotor_-35 1717785..1717791 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1717806..1717825 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1717808..1717932 /Source="Nicolas_S_feature" /locus_tag="new_1717808_1717932" /HighExp="GM 45, GM 15, H2O2, M9-exp, LBGexp, C30, MG 90, GM-0.1, G135, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S586" upshifts 1717808 /Source="Nicolas_upshifts" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1717933..1718673 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9090122, 10675340, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S2" /protein_id="NP_389531.1" /db_xref="EnsemblGenomes-Gn:BSU16490" /db_xref="EnsemblGenomes-Tr:CAB13522" /db_xref="GOA:P21464" /db_xref="InterPro:IPR001865" /db_xref="InterPro:IPR005706" /db_xref="InterPro:IPR018130" /db_xref="InterPro:IPR023591" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19004" /db_xref="UniProtKB/Swiss-Prot:P21464" /translation="MSVISMKQLLEAGVHFGHQTRRWNPKMKRYIFTERNGIYIIDLQ KTVKKVEEAYNFTKNLAAEGGKILFVGTKKQAQDSVKEEAQRSGMYYVNQRWLGGTLT NFETIQKRIKRLKDIEKMQENGTFDVLPKKEVVQLKKELERLEKFLGGIKDMKDLPDA LFIIDPRKERIAVAEARKLNIPIIGIVDTNCDPDEIDVVIPANDDAIRAVKLLTSKMA DAILEAKQGEEEAEVAEETAPETETTTA*" gene 1717933..1718673 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" downshifts 1718655 /Source="Nicolas_upshifts" /id="D896" /incds=0 /nref=4 /ntot=61 /MaxReadThrough="9.04923" /MaxDrop="4.1312" /score="7.42766835" /energy="-14.3" /TU="U1324,U1328" /idTUdmin="U1323" /TUdmin=869 /isTUend="FALSE" S_feature 1718700..1718774 /Source="Nicolas_S_feature" /locus_tag="new_1718700_1718774" /HighExp="LPh, dia0, G150, G180, LBGexp, Lbexp, HPh, Oxctl, dia15, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S587" CDS 1718775..1719656 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6396082, 9244380, 9973356, 27624934; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor Ts" /protein_id="NP_389532.1" /db_xref="EnsemblGenomes-Gn:BSU16500" /db_xref="EnsemblGenomes-Tr:CAB13523" /db_xref="GOA:P80700" /db_xref="InterPro:IPR001816" /db_xref="InterPro:IPR009060" /db_xref="InterPro:IPR014039" /db_xref="InterPro:IPR018101" /db_xref="InterPro:IPR036402" /db_xref="SubtiList:BG19025" /db_xref="UniProtKB/Swiss-Prot:P80700" /translation="MAITAQQVKELREKTGAGMMDCKKALTETDGDMDKAIDLLREKG IAKAAKKADRIAAEGSTLIKTDGNKGVILEVNSETDFVAKNEGFKELLNTLADHLLAN TPADVEEAMGQKMENGSTVEEYITSAVAKIGEKITLRRFTVLTKDDSSAFGAYLHMGG RIGVLTVLNGTTDEETAKDIAMHVAAVNPRYISRDQVSEEETNHERQILTQQALQEGK PENIVAKMVEGRLNKFFEEICLLDQAFVKNPDEKVKQVIAAKNATVQTFVRYEVGEGI EKRQENFAEEVMNQVKK*" gene 1718775..1719656 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" S_feature 1719657..1719801 /Source="Nicolas_S_feature" /locus_tag="new_1719657_1719801" /HighExp="LBGexp, G150, LBGtran, G135, G180, LPh, Oxctl, dia0, Lbexp, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S588" CDS 1719802..1720524 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" /EC_number="2.7.4.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9862121, 12682299, 12869195, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9862121, 12682299, 12869195, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridylate kinase" /protein_id="NP_389533.2" /db_xref="EnsemblGenomes-Gn:BSU16510" /db_xref="EnsemblGenomes-Tr:CAB13524" /db_xref="GOA:O31749" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR011817" /db_xref="InterPro:IPR015963" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG12675" /db_xref="UniProtKB/Swiss-Prot:O31749" /translation="MEKPKYKRIVLKLSGEALAGEQGNGINPTVIQSIAKQVKEIAEL EVEVAVVVGGGNLWRGKTGSDLGMDRATADYMGMLATVMNSLALQDSLETLGIQSRVQ TSIEMRQVAEPYIRRKAIRHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEADVILM AKNNVDGVYNADPRKDESAVKYESLSYLDVLKDGLEVMDSTASSLCMDNDIPLIVFSI MEEGNIKRAVIGESIGTIVRGK*" gene 1719802..1720524 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" CDS 1720526..1721083 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9862121, 12480895, 12682299, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome recycling factor" /protein_id="NP_389534.1" /db_xref="EnsemblGenomes-Gn:BSU16520" /db_xref="EnsemblGenomes-Tr:CAB13525" /db_xref="GOA:P81101" /db_xref="InterPro:IPR002661" /db_xref="InterPro:IPR023584" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12587" /db_xref="UniProtKB/Swiss-Prot:P81101" /translation="MSKEVLTQTKEKMEKAIAAYQRELATVRAGRANPSLLDKVTVEY YGAQTPLNQLSSINVPEARMLVITPYDKTAIGDIEKAILKADLGLTPTSDGNMIRIAI PALTEERRKELVKVVKKYAEEAKVAVRNVRRDANDDLKKLEKNGDITEDELRASTEDV QKLTDEYVSKIDSVTKDKEKEIMEV*" gene 1720526..1721083 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" downshifts complement(1721030) /Source="Nicolas_upshifts" /id="D897" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="3.38183" /MaxDrop="3.17183" /score="-5.69560888" /energy="-4.8" /TU="NA" /idTUdmin="U1326" /TUdmin="-10739" /isTUend="FALSE" promotor_-35 1721072..1721075 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1721090..1721109 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1721108..1721213 /Source="Nicolas_S_feature" /locus_tag="new_1721108_1721213" /HighExp="G180, G135, T3.30H, Oxctl, G150, Cold, Paraq, C30, T3.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S589" upshifts 1721108 /Source="Nicolas_upshifts" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1721214..1721996 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" /EC_number="2.5.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15788389, 16014871, 22904278, 23840410, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15788389, 16014871, 22904278, 23840410, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate synthase" /protein_id="NP_389535.1" /db_xref="EnsemblGenomes-Gn:BSU16530" /db_xref="EnsemblGenomes-Tr:CAB13526" /db_xref="GOA:O31751" /db_xref="InterPro:IPR001441" /db_xref="InterPro:IPR018520" /db_xref="InterPro:IPR036424" /db_xref="SubtiList:BG13408" /db_xref="UniProtKB/Swiss-Prot:O31751" /translation="MLNILKNWKNQQTAASNLERYTKEDILKGEIPEHIAIIMDGNGR WAKKRSLPRIAGHHEGMKVVKRTTKLANELGVKVLTLYAFSTENWKRPKMEVDFLMKL PEEFLNTYLPELVEENVQVRIIGDETALPAHTLRAIEKAVQDTAQNDGMILNFALNYG GRTEIVSAAKSLAEKVKEGSLNIEDIDESLFSTYLMTESLQDPELLIRTSGEIRLSNF MLWQVAYSEFVFTDVLWPDFKEDHFLQALGEFQQRGRRFGGI*" gene 1721214..1721996 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" CDS 1722000..1722809 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" /EC_number="2.7.7.41" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 175832, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidate cytidylyltransferase (CDP-diglyceride synthase)" /protein_id="NP_389536.1" /db_xref="EnsemblGenomes-Gn:BSU16540" /db_xref="EnsemblGenomes-Tr:CAB13527" /db_xref="GOA:O31752" /db_xref="InterPro:IPR000374" /db_xref="SubtiList:BG12575" /db_xref="UniProtKB/Swiss-Prot:O31752" /translation="MVDMKQRILTGVLAAIVFLFLVIVGKLPFTILIYAMGSVALFEL LRMKKLKLVSLPGLIGLLLLWMFLLPSQYSFFEADGISKMEIALFAVLLLLTYTVLVK NTFTFDEVGFITLAAIYIGMCFHYFIEIRNLDQYGLTYIFYACVVIWSTDSGAYFVGK SLGKRKLWPEISPNKTVEGFAGGIVIALVLATIFQLVAQLPIPYIYLLLITLFLSVFG QLGDLVESALKRHYDVKDSGNILPGHGGILDRFDSFLFVMPFLYFLLALFS*" gene 1722000..1722809 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" promotor_-35 1722790..1722797 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1722812..1722831 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1722813 /Source="Nicolas_upshifts" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1722871..1724022 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" /EC_number="1.1.1.267" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15567415, 17458547, 21296950, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15567415, 17458547, 21296950, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-deoxy-D-xylulose-5-phosphate reductoisomerase" /protein_id="NP_389537.2" /db_xref="EnsemblGenomes-Gn:BSU16550" /db_xref="EnsemblGenomes-Tr:CAB13528" /db_xref="GOA:O31753" /db_xref="InterPro:IPR003821" /db_xref="InterPro:IPR013512" /db_xref="InterPro:IPR013644" /db_xref="InterPro:IPR026877" /db_xref="InterPro:IPR036169" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13409" /db_xref="UniProtKB/Swiss-Prot:O31753" /translation="MKNICLLGATGSIGEQTLDVLRAHQDQFQLVSMSFGRNIDKAVP MIEVFQPKFVSVGDLDTYHKLKQMSFSFECQIGLGEEGLIEAAVMEEVDIVVNALLGS VGLIPTLKAIEQKKTIALANKETLVTAGHIVKEHAKKYDVPLLPVDSEHSAIFQALQG EQAKNIERLIITASGGSFRDKTREELESVTVEDALKHPNWSMGAKITIDSATMMNKGL EVIEAHWLFDIPYEQIDVVLHKESIIHSMVEFHDKSVIAQLGTPDMRVPIQYALTYPD RLPLPDAKRLELWEIGSLHFEKADFDRFRCLQFAFESGKIGGTMPTVLNAANEVAVAA FLAGKIPFLAIEDCIEKALTRHQLLKKPSLADIQEVDKDTRGYVNSILT*" gene 1722871..1724022 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" CDS 1724029..1725297 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" /EC_number="3.4.24.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inner membrane zinc metalloprotease required forthe extracytoplasmic stress response mediated by sigma(W)" /protein_id="NP_389538.1" /db_xref="EnsemblGenomes-Gn:BSU16560" /db_xref="EnsemblGenomes-Tr:CAB13529" /db_xref="GOA:O31754" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR004387" /db_xref="InterPro:IPR008915" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG13410" /db_xref="UniProtKB/Swiss-Prot:O31754" /translation="MFVNTVIAFIIIFGTLVFFHELGHLLLAQRAGILCREFAIGFGP KIFSFKKNETVYTIRLLPVGGFVRMAGEDPEMIEVKPGYTVGLLFNKEDQVEKVIINQ KEKYPDALVIEVETADLEHDMKITGYEQGKEDELSSFTVSETSFFIVDGEEVQIAPYN RQFGSKPVWQRIKAIAAGPIMNFILAYVILVMLGLIQGVPSNEPMLGQLTDNGRAAEA GLKEGDYIQSINGEKMRSWTDIVSAVKENPEKEMDVAVKRDNKTLHISVTPEAVKDEN KKTIGRFGSYAPTEKGVLSAVAYGATSTVDVTKAILTNLSKLVTGQFKLDMLSGPVGI YDMTDQVAKTGIVNLFQFAAFLSINLGIVNLLPIPALDGGRLLFLFIEAIRGKPINRE KEAFVVFIGVAFLMLLMLVVTWNDIQRLFL*" gene 1724029..1725297 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" CDS 1725330..1727024 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" /EC_number="6.1.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16864571, 26886480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl-tRNA synthetase" /protein_id="NP_389539.1" /db_xref="EnsemblGenomes-Gn:BSU16570" /db_xref="EnsemblGenomes-Tr:CAB13530" /db_xref="GOA:O31755" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002316" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004500" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR023717" /db_xref="InterPro:IPR033730" /db_xref="InterPro:IPR036621" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12659" /db_xref="UniProtKB/Swiss-Prot:O31755" /translation="MRQSLTLIPTLREVPADAEAKSHQLLLRAGFIRQNTSGVYSYMP LAYKVIQNIQQIVREEMEKIDAVEMLMPALQQAETWQESGRWYTYGPELMRLKDRHGR EFALGATHEEVITSLVRDEVKSYKRLPLTLYQIQSKFRDEKRPRFGLLRGREFIMKDA YSFHASAESLDETYQKMYEAYSNIFARCGINVRPVIADSGAMGGKDTHEFMALSAIGE DTIAYSDESQYAANIEMAEVLHQEVPSDEEPKALEKVHTPNVKTIEELTAFLQVSAEA CIKSVLFKADDRFVLVLVRGDHEVNDIKVKNLLHAEVVELATHEEVIQQLGTEPGFVG PVGIHQDVEVYADQAVKAMVNAVAGANEGDHHYKNVNVNRDAQIKEFADLRFIKEGDP SPDGKGTIRFAEGIEVGQVFKLGTRYSEAMNATYLDENGRAQPMLMGCYGIGVSRTLS AIAEQHHDEKGLIWPKSVAPYDLHILALNMKNDGQRELAEKLYADLKAEGYEVLYDDR AERAGVKFADSDLIGLPIRITVGKRADEGIVEVKIRQTGESTEISVDELSAFISKQ*" gene 1725330..1727024 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" S_feature 1727025..1727132 /Source="Nicolas_S_feature" /locus_tag="new_1727025_1727132" /HighExp="G135, G180, G150, C30, Oxctl, H2O2, Paraq, LPh, LBGexp, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S590" CDS 1727133..1731446 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit)" /protein_id="NP_389540.1" /db_xref="EnsemblGenomes-Gn:BSU16580" /db_xref="EnsemblGenomes-Tr:CAB13531" /db_xref="GOA:P13267" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006308" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR024754" /db_xref="InterPro:IPR028112" /db_xref="InterPro:IPR029460" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG10263" /db_xref="UniProtKB/Swiss-Prot:P13267" /translation="MEQLSVNRRQFQILLQQINMTDDTFMTYFEHGEIKKLTIHKASK SWHFHFQFKSLLPFQIYDTLTTRLTQSFAHIAKVTSSIEVQDAEVSESIVQDYWSRCI EELQGISPPIISLLNQQKPKLKGNKLIVKTKTDTEAAALKNKYSSMIQAEYRQFGFPD LQLDAEIFVSEQEVQKFREQKLAEDQERAMQALIEMEKKDKESDEDQAPSGPLVIGYQ IKDNEEIRTLDSIMDEERRITVQGYVFDVETRELKSGRTLCIFKITDYTNSILIKMFA REKEDAALMKSLKKGMWVKARGSIQNDTFVRDLVMIANDVNEIKAKTREDSAPEGEKR VELHLHSPMSQMDAVTGIGKLVEQAKKWGHEAIALTDHAVVQSFPDAYSAAKKHGIKM IYGMEANLVDDGVPIAYNAAHRLLEEETYVVFDVETTGLSAVYDTIIELAAVKVKGGE IIDKFEAFANPHRPLSATIIELTGITDDMLQDAPDVVDVIRDFREWIGDDILVAHNAS FDMGFLNVAYKKLLEVEKAKNPVIDTLELGRFLYPEFKNHRLNTLCKKFDIELTQHHR AIYDTEATAYLLLKMLKDAAEKGIQYHDELNENMGQSNAYQRSRPYHATLLAVNSTGL KNLFKLVSLSHIHYFYRVPRIPRSQLEKYREGLLIGSACDRGEVFEGMMQKSPEEVED IASFYDYLEVQPPEVYRHLLELELVRDEKALKEIIANITKLGEKLNKPVVATGNVHYL NDEDKIYRKILISSQGGANPLNRHELPKVHFRTTDEMLEAFSFLGEEKAKEIVVTNTQ KVASLVDDIKPIKDDLYTPKIEGADEEIREMSYQRARSIYGEELPEIVEARIEKELKS IIGHGFAVIYLISHKLVKRSLDDGYLVGSRGSVGSSLVATLTEITEVNPLPPHYVCPE CQHSEFFNDGSVGSGFDLPDKTCPHCGTPLKKDGHDIPFETFLGFKGDKVPDIDLNFS GEYQPQAHNYTKVLFGEDNVYRAGTIGTVAEKTAYGYVKGYAGDNNLHMRGAEIDRLV QGCTGVKRTTGQHPGGIIVVPDYMDIYDFSPIQFPADATGSEWKTTHFDFHSIHDNLL KLDILGHDDPTVIRMLQDLSGIDPKTIPTDDPEVMKIFQGTESLGVTEEQIGCKTGTL GIPEFGTRFVRQMLEDTKPTTFSELVQISGLSHGTDVWLGNAQELIHNNICELSEVIG CRDDIMVYLIYQGLEPSLAFKIMEFVRKGKGLTPEWEEEMKNNNVPDWYIDSCKKIKY MFPKAHAAAYVLMAVRIAYFKVHHALLYYAAYFTVRADDFDIDTMIKGSTAIRAVMED INAKGLDASPKEKNLLTVLELALEMCERGYSFQKVDLYRSSATEFIIDGNSLIPPFNS IPGLGTNAALNIVKAREEGEFLSKEDLQKRGKVSKTILEYLDRHGCLESLPDQNQLSL F*" gene 1727133..1731446 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" S_feature 1731447..1731511 /Source="Nicolas_S_feature" /locus_tag="new_1731447_1731511" /HighExp="C30, G180, G135, Oxctl, G150, H2O2, Paraq, Cold, LBGstat, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S591" misc_RNA 1731457..1731674 /gene="surG" /locus_tag="BSU_misc_RNA_71" /product="small RNAs controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" gene 1731457..1731674 /gene="surG" /locus_tag="BSU_misc_RNA_71" promotor_-35 1731483..1731489 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-35" promotor_-10 1731504..1731515 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-10" S_feature 1731513..1731580 /Source="Nicolas_S_feature" /locus_tag="new_1731513_1731580" /HighExp="S7, S5, S4, S8, S6, S3, G180, C30, T5.0H, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S592" upshifts 1731513 /Source="Nicolas_upshifts" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" promotor_-35 1731563..1731569 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-35" S_feature 1731582..1731775 /Source="Nicolas_S_feature" /locus_tag="new_1731582_1731775" /HighExp="LoTm, Cold, HPh, G180, Paraq, Oxctl, T-5.40H, BMM, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S593" upshifts 1731582 /Source="Nicolas_upshifts" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" promotor_-10 1731583..1731602 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-10" CDS 1731776..1732246 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15257761, 16014871, 19150615, 20188109, 21529161; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome maturation factor" /protein_id="NP_389541.1" /db_xref="EnsemblGenomes-Gn:BSU16590" /db_xref="EnsemblGenomes-Tr:CAB13532" /db_xref="GOA:P32726" /db_xref="InterPro:IPR003728" /db_xref="InterPro:IPR028989" /db_xref="InterPro:IPR028998" /db_xref="InterPro:IPR035956" /db_xref="InterPro:IPR036847" /db_xref="SubtiList:BG10264" /db_xref="UniProtKB/Swiss-Prot:P32726" /translation="MSKKVTDTVQEMAQPIVDSLQLELVDIEFVKEGQSWFLRVFIDS DDGVDIEECAKVSEALSEKLDEADPISQNYFLEVSSPGAERPLKKKADFEKSLGKNVY IKTYEPIDGVKVFEGELAEFDGQTVTVEITIKTRKKRINIPYEKIANARLAVTF*" gene 1731776..1732246 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" downshifts complement(1732097) /Source="Nicolas_upshifts" /id="D898" /incds=1 /nref=3 /ntot=136 /MaxReadThrough="2.08299" /MaxDrop="3.17419" /score="-8.18111474" /energy="-9.2" /TU="NA" /idTUdmin="U1333" /TUdmin=0 /isTUend="TRUE" CDS 1732281..1733396 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15978071, 16707701, 16946247, 27571753, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15978071, 16707701, 16946247, 27571753, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="transcription translation coupling factor involved in Rho-dependent transcription termination" /protein_id="NP_389542.1" /db_xref="EnsemblGenomes-Gn:BSU16600" /db_xref="EnsemblGenomes-Tr:CAB13533" /db_xref="GOA:P32727" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR010213" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013735" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR025249" /db_xref="InterPro:IPR030842" /db_xref="InterPro:IPR036555" /db_xref="PDB:2MT4" /db_xref="SubtiList:BG10265" /db_xref="UniProtKB/Swiss-Prot:P32727" /translation="MSSELLDALTILEKEKGISKEIIIEAIEAALISAYKRNFNQAQN VRVDLNRETGSIRVFARKDVVDEVYDQRLEISIEEAQGIHPEYMVGDVVEIEVTPKDF GRIAAQTAKQVVTQRVREAERGVIYSEFIDREEDIMTGIVQRLDNKFIYVSLGKIEAL LPVNEQMPNESYKPHDRIKVYITKVEKTTKGPQIYVSRTHPGLLKRLFEIEVPEIYDG TVELKSVAREAGDRSKISVRTDDPDVDPVGSCVGPKGQRVQAIVNELKGEKIDIVNWS SDPVEFVANALSPSKVLDVIVNEEEKATTVIVPDYQLSLAIGKRGQNARLAAKLTGWK IDIKSETDARELGIYPRELEEDDEPLFTEPETAESDE*" gene 1732281..1733396 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" promotor_no_box complement(1732343..1732443) /Source="Nicolas_upshift_promotors" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1732383) /Source="Nicolas_upshifts" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1733410..1733685 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11679764, 12682299, 26771646, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular ruler co-factor for RNA; new fold" /protein_id="NP_389543.1" /db_xref="EnsemblGenomes-Gn:BSU16610" /db_xref="EnsemblGenomes-Tr:CAB13534" /db_xref="InterPro:IPR007393" /db_xref="InterPro:IPR035931" /db_xref="SubtiList:BG10266" /db_xref="UniProtKB/Swiss-Prot:P32728" /translation="MNKHKKIPLRKCVVTGEMKPKKELIRVVRSKEGEISVDPTGKKN GRGAYLTLDKECILAAKKKNTLQNQFQSQIDDQIFDELLELAEKVKK*" gene 1733410..1733685 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" CDS 1733687..1733989 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15130481, 15361074, 22355167, 26522935, 26771646" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130481, 15361074, 22355167, 26522935, 26771646; Product type f: factor" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein" /protein_id="NP_389544.1" /db_xref="EnsemblGenomes-Gn:BSU16620" /db_xref="EnsemblGenomes-Tr:CAB13535" /db_xref="GOA:P32729" /db_xref="InterPro:IPR004037" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7Q" /db_xref="SubtiList:BG10267" /db_xref="UniProtKB/Swiss-Prot:P32729" /translation="MSGMEWFPLLGLANRARKVVSGEDLVIKEIRNARAKLVLLTEDA SSNTAKKVTDKCNYYKVPYKKVESRAVLGRSIGKEARVVVAVTDQGFANKLISLLD*" gene 1733687..1733989 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" CDS 1734009..1736159 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1426242, 9588797, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1426242, 9588797, 12682299, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-2" /protein_id="NP_389545.1" /db_xref="EnsemblGenomes-Gn:BSU16630" /db_xref="EnsemblGenomes-Tr:CAB13536" /db_xref="GOA:P17889" /db_xref="InterPro:IPR000178" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006847" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR015760" /db_xref="InterPro:IPR023115" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036925" /db_xref="SubtiList:BG10268" /db_xref="UniProtKB/Swiss-Prot:P17889" /translation="MAKMRVYEYAKALNVSSKEILTALKNMDLEVNNHMAMLEEKAIK KLDAKYKKGGAAAKSQKPAETNKNKQPQGVNQQSAGNQPNKIRDGKKNDVQNNQFNKN KKNNNNKKNKRNNNNNKNQHQQKPVKPKKELPEKITFSGTLTVGALAEELGKEPSELI KKLMLLGVMATINQELDKDTIELIASEYGVETEEVIVLEETELEKYEEPDNEEDLEIR PPVVTIMGHVDHGKTTLLDSIRKTKVVEGEAGGITQHIGAYQIEENGKKITFLDTPGH AAFTTMRARGAEVTDITILVVAADDGVMPQTVEAINHAKAAEVPIIVAVNKIDKESAN PDRVMQELTEYGLVPEAWGGETIFVPLSALTGKGIDELVEMILLVSEVEELKANPNRQ AKGTVIEAELDKGRGSVATLLVQTGTLHVGDPIVVGNTFGRVRAMVNDIGRRVKTAGP STPVEITGLNDVPQAGDQFLVFKDEKTARSVGEARASKQLEEQRSDKAKLSLDDLFEQ IKQGDVKDINLIVKADVQGSAEALTAALQKIEVEGVKVKIIHTGVGAITESDIILASA SNAIVIGFNVRPDGNAKSTAEAENVDIRLHRIIYKVIDEIEAAMKGMLDPEYEEKVIG QVEVRQTFKVSKIGTIAGGYVTEGTITRDSGLRLIRDGVVIFEGEVDVLKRFKDDVKE VSQGYECGITIKKYNDIREGDILEAFVMQEIERT*" gene 1734009..1736159 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" promotor_-35 1736054..1736060 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1736069 /Source="Nicolas_upshifts" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" promotor_-10 1736075..1736093 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1736156..1736434 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of conserved protein" /db_xref="EnsemblGenomes-Gn:BSU16640" /db_xref="EnsemblGenomes-Tr:CAB13537" /db_xref="InterPro:IPR007546" /db_xref="InterPro:IPR036746" /db_xref="PSEUDO:CAB13537.1" /db_xref="SubtiList:BG10269" /db_xref="UniProtKB/Swiss-Prot:P32730" /translation="MIGFAECECIIYDAGSLKEKRAVLKRILTRVQNKFNVSISEIGY QDTWQRTSFGIAAVSSSRVQTEKELQRVLAFIDSFPEIERTITRTEWF*" gene 1736156..1736434 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /pseudo CDS 1736451..1736804 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12628255, 15185964, 17996707, 21102555, 21529161, 23293003, 23611982, 24671761, 25904134, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="pre-ribosomal (17S) RNA binding factor A" /protein_id="NP_389547.1" /db_xref="EnsemblGenomes-Gn:BSU16650" /db_xref="EnsemblGenomes-Tr:CAB13538" /db_xref="GOA:P32731" /db_xref="InterPro:IPR000238" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020053" /db_xref="InterPro:IPR023799" /db_xref="SubtiList:BG10270" /db_xref="UniProtKB/Swiss-Prot:P32731" /translation="MSMRANRVGEQMKKELGDIISRKLKDPRIGFLTVTDVRVSGDLQ IAKVYISVLGDEKKREEALKGLAKAKGFIRSEIGSRIRLRKTPEIEFEFDESIDYGNR IETLIHELHSEKPSE*" gene 1736451..1736804 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" downshifts 1736795 /Source="Nicolas_upshifts" /id="D899" /incds=0 /nref=9 /ntot=130 /MaxReadThrough="6.97196" /MaxDrop="5.80207" /score="-3.06560848" /energy="-13.8" /TU="U1331,U1332,U1334" /idTUdmin="U1331" /TUdmin="-308" /isTUend="FALSE" CDS 1736886..1737815 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" /EC_number="5.4.99.25" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7489483, 15987897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine 55 synthase" /protein_id="NP_389548.1" /db_xref="EnsemblGenomes-Gn:BSU16660" /db_xref="EnsemblGenomes-Tr:CAB13539" /db_xref="GOA:P32732" /db_xref="InterPro:IPR002501" /db_xref="InterPro:IPR014780" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR032819" /db_xref="SubtiList:BG10271" /db_xref="UniProtKB/Swiss-Prot:P32732" /translation="MVNGVLLLHKPVGMTSHDCVMKIRKLLKTKKVGHTGTLDPEVSG VLPICVGRATKIVEYLTEKSKTYDAEITLGFSTTTEDQTGETVETKPVNHDIDKADVE KVLNSLKGKQEQIPPMYSAVKVNGKKLYEYARAGIEVERPKRMITIEDIALTTEIKHH GETASFRFTVTCSKGTYVRTLAVMIGEKLGYPAHMSHLIRTASGDFSLDECFTFDELE AQAQSGTVEEHTVPIERALNHLPKWIISDTLAKKVENGALLETPEQFSEMTSGDRIAV FTESGTCLAIYFPHPAKKGLLKPAKVLMQKSEQ*" gene 1736886..1737815 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" promotor_-35 1737600..1737607 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1737621..1737640 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1737630 /Source="Nicolas_upshifts" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" CDS 1737834..1738784 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" /EC_number="2.7.1.26" /EC_number="2.7.7.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9473052, 10206712, 12456892, 15668000, 18156273, 21866869" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9473052, 10206712, 12456892, 15668000, 18156273, 21866869; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="bifunctional riboflavin kinase FAD synthase" /protein_id="NP_389549.1" /db_xref="EnsemblGenomes-Gn:BSU16670" /db_xref="EnsemblGenomes-Tr:CAB13540" /db_xref="GOA:P54575" /db_xref="InterPro:IPR002606" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015864" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11495" /db_xref="UniProtKB/Swiss-Prot:P54575" /translation="MKTIHITHPHHLIKEEQAKSVMALGYFDGVHLGHQKVIGTAKQI AEEKGLTLAVMTFHPHPSHVLGRDKEPKDLITPLEDKINQIEQLGTEVLYVVKFNEVF ASLSPKQFIDQYIIGLNVQHAVAGFDFTYGKYGKGTMKTMPDDLDGKAGCTMVEKLTE QDKKISSSYIRTALQNGDVELANVLLGQPYFIKGIVIHGDKRGRTIGFPTANVGLNNS YIVPPTGVYAVKAEVNGEVYNGVCNIGYKPTFYEKRPEQPSIEVNLFDFNQEVYGAAI KIEWYKRIRSERKFNGIKELTEQIEKDKQEAIRYFSNLRK*" gene 1737834..1738784 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" promotor_-35 1738817..1738823 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1738824..1738940 /Source="Nicolas_S_feature" /locus_tag="new_1738824_1738940" /HighExp="SMM, GM 15, Salt, T-4.40H, GM 45, T-5.40H, GM 60, MG 45, LPhT, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S594" upshifts 1738824 /Source="Nicolas_upshifts" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" promotor_-10 1738838..1738857 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1738941..1739210 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15627386, 8825778, 20418391, 22720735, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15627386, 8825778, 20418391, 22720735, 23611891; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S15 (BS18)" /protein_id="NP_389550.1" /db_xref="EnsemblGenomes-Gn:BSU16680" /db_xref="EnsemblGenomes-Tr:CAB13541" /db_xref="GOA:P21473" /db_xref="InterPro:IPR000589" /db_xref="InterPro:IPR005290" /db_xref="InterPro:IPR009068" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19010" /db_xref="UniProtKB/Swiss-Prot:P21473" /translation="MAITQERKNQLINEFKTHESDTGSPEVQIAILTDSINNLNEHLR THKKDHHSRRGLLKMVGKRRNLLTYLRNKDVTRYRELINKLGLRR*" gene 1738941..1739210 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" downshifts 1739193 /Source="Nicolas_upshifts" /id="D900" /incds=0 /nref=30 /ntot=154 /MaxReadThrough="8.65904" /MaxDrop="5.6648" /score="29.9198852" /energy="-10.2" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1331" /TUdmin=2090 /isTUend="FALSE" S_feature 1739238..1739323 /Source="Nicolas_S_feature" /locus_tag="new_1739238_1739323" /HighExp="Cold, LoTm, Oxctl, G180, H2O2, G150, dia15, Paraq, LPh, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S595" promotor_-35 1739304..1739307 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1739323..1739342 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1739325 /Source="Nicolas_upshifts" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" CDS 1739383..1741500 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" /EC_number="2.7.7.8" /EC_number="3.1.13.1" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polynucleotide phosphorylase (PNPase)" /protein_id="NP_389551.1" /db_xref="EnsemblGenomes-Gn:BSU16690" /db_xref="EnsemblGenomes-Tr:CAB13542" /db_xref="GOA:P50849" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR012162" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR015848" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="InterPro:IPR036456" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG11491" /db_xref="UniProtKB/Swiss-Prot:P50849" /translation="MGQEKHVFTIDWAGRTLTVETGQLAKQANGAVMIRYGDTAVLST ATASKEPKPLDFFPLTVNYEERLYAVGKIPGGFIKREGRPSEKAVLASRLIDRPIRPL FADGFRNEVQVISIVMSVDQNCSSEMAAMFGSSLALSVSDIPFEGPIAGVTVGRIDDQ FIINPTVDQLEKSDINLVVAGTKDAINMVEAGADEVPEEIMLEAIMFGHEEIKRLIAF QEEIVAAVGKEKSEIKLFEIDEELNEKVKALAEEDLLKAIQVHEKHAREDAINEVKNA VVAKFEDEEHDEDTIKQVKQILSKLVKNEVRRLITEEKVRPDGRGVDQIRPLSSEVGL LPRTHGSGLFTRGQTQALSVCTLGALGDVQILDGLGVEESKRFMHHYNFPQFSVGETG PMRGPGRREIGHGALGERALEPVIPSEKDFPYTVRLVSEVLESNGSTSQASICASTLA MMDAGVPIKAPVAGIAMGLVKSGEHYTVLTDIQGMEDALGDMDFKVAGTEKGVTALQM DIKIEGLSREILEEALQQAKKGRMEILNSMLATLSESRKELSRYAPKILTMTINPDKI RDVIGPSGKQINKIIEETGVKIDIEQDGTIFISSTDESGNQKAKKIIEDLVREVEVGQ LYLGKVKRIEKFGAFVEIFSGKDGLVHISELALERVGKVEDVVKIGDEILVKVTEIDK QGRVNLSRKAVLREEKEKEEQQS*" gene 1739383..1741500 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" downshifts 1741283 /Source="Nicolas_upshifts" /id="D901" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.05841" /MaxDrop="3.82025" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336,U1337" /idTUdmin="U1337" /TUdmin="-198" /isTUend="FALSE" downshifts 1741484 /Source="Nicolas_upshifts" /id="D902" /incds=0 /nref=192 /ntot=270 /MaxReadThrough="5.61214" /MaxDrop="6.82185" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1337" /TUdmin=3 /isTUend="TRUE" S_feature 1741529..1741617 /Source="Nicolas_S_feature" /locus_tag="new_1741529_1741617" /HighExp="G135, G180, G150, H2O2, Oxctl, LBGexp, Paraq, LoTm, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S596" CDS 1741618..1742577 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14679227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar deacetylase" /protein_id="NP_389552.1" /db_xref="EnsemblGenomes-Gn:BSU16700" /db_xref="EnsemblGenomes-Tr:CAB13543" /db_xref="GOA:P50850" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR010916" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014228" /db_xref="SubtiList:BG11492" /db_xref="UniProtKB/Swiss-Prot:P50850" /translation="MYKKFVPFAVFLFLFFVSFEMMENPHALDYIGAMKKDTVTVTAS KDPLYEELLQKAPEYEVKPQNARIDKVWKSIPGYNGLKVNIEQSYKKMKQHGKFREKD LVYSQVKPSVHLESLQPEPIYKGNPDKPMVAFLINVAWGNEYLEKMLPILQKHQVKAT FFLEGNWVRNNVQLAKKIAKDGHEIGNHSYNHPDMSKLTTGRISEQLDKTNEQIEQTI GVKPKWFAPPSGSFRKAVIDIAAEKQMGTVMWTVDTIDWQKPAPSVLQTRVLSKIHNG AMILMHPTDPTAESLEALITQIKDKGYALGTVTELMDETRLLK*" gene 1741618..1742577 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" promotor_-10 complement(1741686..1741694) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1741689) /Source="Nicolas_upshifts" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1741708..1741715) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1742181..1742186 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1742202..1742220 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1742207 /Source="Nicolas_upshifts" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" CDS 1742617..1743846 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10666719, 10974125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666719, 10974125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="specific processing protease" /protein_id="NP_389553.2" /db_xref="EnsemblGenomes-Gn:BSU16710" /db_xref="EnsemblGenomes-Tr:CAB13544" /db_xref="GOA:Q04805" /db_xref="InterPro:IPR001431" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG10779" /db_xref="UniProtKB/Swiss-Prot:Q04805" /translation="MIKRYTCQNGVRIVLENNPTVRSVAIGVWIGTGSRHETPEINGI SHFLEHMFFKGTSTKSAREIAESFDRIGGQVNAFTSKEYTCYYAKVLDEHANYALDVL ADMFFHSTFDENELKKEKNVVYEEIKMYEDAPDDIVHDLLSKATYGNHSLGYPILGTE ETLASFNGDSLRQYMHDYYTPDRVVISVAGNISDSFIKDVEKWFGSYEAKGKATGLEK PEFHTEKLTRKKETEQAHLCLGFKGLEVGHERIYDLIVLNNVLGGSMSSRLFQDVRED KGLAYSVYSYHSSYEDSGMLTIYGGTGANQLQQLSETIQETLATLKRDGITSKELENS KEQMKGSLMLSLESTNSKMSRNGKNELLLGKHKTLDEIINELNAVNLERVNGLARQLF TEDYALALISPSGNMPS*" gene 1742617..1743846 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" downshifts 1743835 /Source="Nicolas_upshifts" /id="D903" /incds=0 /nref=140 /ntot=219 /MaxReadThrough="1.31218" /MaxDrop="4.84427" /score="15.1952611" /energy="-12.6" /TU="NA" /idTUdmin="U1336" /TUdmin=0 /isTUend="TRUE" promotor_-35 1743875..1743880 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1743890 /Source="Nicolas_upshifts" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" promotor_-10 1743896..1743914 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1743924..1744181 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" /experiment="publication(s) with functional evidences, PMID:23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="PRC barrel protein involved in sporulation" /protein_id="NP_389554.1" /db_xref="EnsemblGenomes-Gn:BSU16720" /db_xref="EnsemblGenomes-Tr:CAB13545" /db_xref="GOA:Q04811" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG10780" /db_xref="UniProtKB/Swiss-Prot:Q04811" /translation="MRLSELSGKEIVDIKRAERLGVLGQTDLEINEQDGQITALLIPT VKWFGLRKQGHDIRVPWHHIQKIGSDMIILDVPEEMPPRQE*" gene 1743924..1744181 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" S_feature 1744182..1744236 /Source="Nicolas_S_feature" /locus_tag="new_1744182_1744236" /HighExp="S4, S3, S5, S6, S8, S7, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S597" downshifts 1744209 /Source="Nicolas_upshifts" /id="D904" /incds=0 /nref=41 /ntot=56 /MaxReadThrough="0.534319999999999" /MaxDrop="6.36032" /score="29.434739" /energy="-11.7" /TU="NA" /idTUdmin="U1340" /TUdmin=0 /isTUend="TRUE" promotor_-35 1744278..1744287 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-35" S_feature 1744297..1744366 /Source="Nicolas_S_feature" /locus_tag="new_1744297_1744366" /HighExp="S6, S8, S7, BT, B36, S5, G/S, Pyr, B60, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S598" upshifts 1744297 /Source="Nicolas_upshifts" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" promotor_-10 1744301..1744320 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-10" CDS 1744367..1745260 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" /EC_number="1.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit A" /protein_id="NP_389555.1" /db_xref="EnsemblGenomes-Gn:BSU16730" /db_xref="EnsemblGenomes-Tr:CAB13546" /db_xref="GOA:Q04809" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR014215" /db_xref="InterPro:IPR031629" /db_xref="InterPro:IPR036291" /db_xref="PDB:2RIR" /db_xref="SubtiList:BG10781" /db_xref="UniProtKB/Swiss-Prot:Q04809" /translation="MLTGLKIAVIGGDARQLEIIRKLTEQQADIYLVGFDQLDHGFTG AVKCNIDEIPFQQIDSIILPVSATTGEGVVSTVFSNEEVVLKQDHLDRTPAHCVIFSG ISNAYLENIAAQAKRKLVKLFERDDIAIYNSIPTVEGTIMLAIQHTDYTIHGSQVAVL GLGRTGMTIARTFAALGANVKVGARSSAHLARITEMGLVPFHTDELKEHVKDIDICIN TIPSMILNQTVLSSMTPKTLILDLASRPGGTDFKYAEKQGIKALLAPGLPGIVAPKTA GQILANVLSKLLAEIQAEEGK*" gene 1744367..1745260 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" CDS 1745263..1745865 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit B" /protein_id="NP_389556.1" /db_xref="EnsemblGenomes-Gn:BSU16740" /db_xref="EnsemblGenomes-Tr:CAB13547" /db_xref="GOA:Q04810" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR014214" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG10782" /db_xref="UniProtKB/Swiss-Prot:Q04810" /translation="MSSLKGKRIGFGLTGSHCTYEAVFPQIEELVNEGAEVRPVVTFN VKSTNTRFGEGAEWVKKIEDLTGYEAIDSIVKAEPLGPKLPLDCMVIAPLTGNSMSKL ANAMTDSPVLMAAKATIRNNRPVVLGISTNDALGLNGTNLMRLMSTKNIFFIPFGQDD PFKKPNSMVAKMDLLPQTIEKALMHQQLQPILVENYQGND*" gene 1745263..1745865 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" misc_feature 1745919..1745938 /Source="Nicolas_upshift_promotors" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1745919..1745990 /Source="Nicolas_S_feature" /locus_tag="new_1745919_1745990" /HighExp="S6, S7, S8, C90, S5, BT, MG 45, MG 5, SMM, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S599" upshifts 1745919 /Source="Nicolas_upshifts" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" CDS 1745991..1747031 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" /EC_number="1.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 12682299, 25355936, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 12682299, 25355936, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate-semialdehyde dehydrogenase" /protein_id="NP_389557.1" /db_xref="EnsemblGenomes-Gn:BSU16750" /db_xref="EnsemblGenomes-Tr:CAB13548" /db_xref="GOA:Q04797" /db_xref="InterPro:IPR000319" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR005986" /db_xref="InterPro:IPR012080" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10783" /db_xref="UniProtKB/Swiss-Prot:Q04797" /translation="MGRGLHVAVVGATGAVGQQMLKTLEDRNFEMDTLTLLSSKRSAG TKVTFKGQELTVQEASPESFEGVNIALFSAGGSVSQALAPEAVKRGAIVIDNTSAFRM DENTPLVVPEVNEADLHEHNGIIANPNCSTIQMVAALEPIRKAYGLNKVIVSTYQAVS GAGNEAVKELYSQTQAILNKEEIEPEIMPVKGDKKHYQIAFNAIPQIDKFQDNGYTFE EMKMINETKKIMHMPDLQVAATCVRLPIQTGHSESVYIEIDRDDATVEDIKNLLKEAP GVTLQDDPSQQLYPMPADAVGKNDVFVGRIRKDLDRANGFHLWVVSDNLLKGAAWNSV QIAESLKKLNLV*" gene 1745991..1747031 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" S_feature 1747032..1747122 /Source="Nicolas_S_feature" /locus_tag="new_1747032_1747122" /HighExp="S7, S6, S8, LBGtran, GM 120, dia15, Heat, LBGstat, GM 90, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S600" CDS 1747123..1748337 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1906928, 8098035" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906928, 8098035; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase I (alpha and beta subunits)" /protein_id="NP_389558.2" /db_xref="EnsemblGenomes-Gn:BSU16760" /db_xref="EnsemblGenomes-Tr:CAB13549" /db_xref="GOA:Q04795" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10784" /db_xref="UniProtKB/Swiss-Prot:Q04795" /translation="MKIIVQKFGGTSVKDDKGRKLALGHIKEAISEGYKVVVVVSAMG RKGDPYATDSLLGLLYGDQSAISPREQDLLLSCGETISSVVFTSMLLDNGVKAAALTG AQAGFLTNDQHTNAKIIEMKPERLFSVLANHDAVVVAGFQGATEKGDTTTIGRGGSDT SAAALGAAVDAEYIDIFTDVEGVMTADPRVVENAKPLPVVTYTEICNLAYQGAKVISP RAVEIAMQAKVPIRVRSTYSNDKGTLVTSHHSSKVGSDVFERLITGIAHVKDVTQFKV PAKIGQYNVQTEVFKAMANAGISVDFFNITPSEIVYTVAGNKTETAQRILMDMGYDPM VTRNCAKVSAVGAGIMGVPGVTSKIVSALSEKEIPILQSADSHTTIWVLVHEADMVPA VNALHEVFELSK*" gene 1747123..1748337 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" CDS 1748368..1749240 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" /EC_number="4.3.3.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 9298659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 9298659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-tetrahydrodipicolinate synthase" /protein_id="NP_389559.1" /db_xref="EnsemblGenomes-Gn:BSU16770" /db_xref="EnsemblGenomes-Tr:CAB13550" /db_xref="GOA:Q04796" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR005263" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020624" /db_xref="InterPro:IPR020625" /db_xref="SubtiList:BG10785" /db_xref="UniProtKB/Swiss-Prot:Q04796" /translation="MNFGNVSTAMITPFDNKGNVDFQKLSTLIDYLLKNGTDSLVVAG TTGESPTLSTEEKIALFEYTVKEVNGRVPVIAGTGSNNTKDSIKLTKKAEEAGVDAVM LVTPYYNKPSQEGMYQHFKAIAAETSLPVMLYNVPGRTVASLAPETTIRLAADIPNVV AIKEASGDLEAITKIIAETPEDFYVYSGDDALTLPILSVGGRGVVSVASHIAGTDMQQ MIKNYTNGQTANAALIHQKLLPIMKELFKAPNPAPVKTALQLRGLDVGSVRLPLVPLT EDERLSLSSTISEL*" gene 1748368..1749240 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" S_feature complement(1748711..1749895) /Source="Nicolas_S_feature" /locus_tag="new_1748711_1749895_c" /HighExp="S8, S6, S4, S5, S7, S3, LoTm, T5.0H, BT, C30" /AntisenseName="dapA" /AntisenseCor="0.13444126275526899" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S601" downshifts 1749247 /Source="Nicolas_upshifts" /id="D905" /incds=0 /nref=17 /ntot=99 /MaxReadThrough="6.0497" /MaxDrop="5.05122" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1341" /TUdmin=0 /isTUend="TRUE" promotor_-35 1749340..1749343 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1749357 /Source="Nicolas_upshifts" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" promotor_-10 1749359..1749378 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1749418..1751085 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual activity 5' exo-and endoribonuclease J2" /protein_id="NP_389560.2" /db_xref="EnsemblGenomes-Gn:BSU16780" /db_xref="EnsemblGenomes-Tr:CAB13551" /db_xref="GOA:O31760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13422" /db_xref="UniProtKB/Swiss-Prot:O31760" /translation="MKKKNTENVRIIALGGVGEIGKNLYVIEIDSDIFVVDAGLMHPE NEMLGIDVVIPDISYLIERADRVKAIFLTHGHDENIGGVFYLLNKLSVPVYGTKLTLA LLREKLKQYGHNRKTDLREIHSKSVITFESTKVSFFRTIHSIPDSVGVSFKTSLGSIV CTGDFKFDQTPALNQTCDIGEIAKIGNSGVLALLSDSANAERPGYTPSEAAVSGEISD ALYNSQNRVIIAVFASNINRIQQVIHAAAQNGRKIAVAGKNLQSVLQLARKLGYIEAD DELFISVQDVKKYPKREVAIITAGSQGEPLAALTRMANKAHKQLNIEEGDTVVIASTP IPGQELIYSKTVDLLARAGAQVIFAQKRVHVSGHGSQEELKLMINLLKPKYLIPVNGE YRMQKAHSKIAEETGMKRSDIFLIEKGDVVEFRGQNVKIGDKVPYGNILIDGLGVGDI GNIVLRDRRLLSQDGILIVVITLDKQKKHLVSGPEIITRGFVYVRESEGLIVQATELV RSIVTEATETSNVEWSTLKQAMRDALNQFLYEKTKRKPMIIPIIMEV*" gene 1749418..1751085 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" promotor_-10 complement(1749882..1749900) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1749899) /Source="Nicolas_upshifts" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" promotor_-35 complement(1749916..1749921) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1751073 /Source="Nicolas_upshifts" /id="D906" /incds=0 /nref=227 /ntot=263 /MaxReadThrough="4.0072" /MaxDrop="6.75416" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1343" /TUdmin=0 /isTUend="TRUE" promotor_-35 1751140..1751146 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-35" promotor_-10 1751160..1751171 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-10" upshifts 1751161 /Source="Nicolas_upshifts" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" CDS 1751201..1751938 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10455123, 15189290, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455123, 15189290, 23927687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein export-enhancing protease (spore outgrowth)" /protein_id="NP_389561.3" /db_xref="EnsemblGenomes-Gn:BSU16790" /db_xref="EnsemblGenomes-Tr:CAB13552" /db_xref="GOA:Q99171" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11055" /db_xref="UniProtKB/Swiss-Prot:Q99171" /translation="MDHRMENTEEERPEKNDAKDSIMNKIQQLGETTLPQLPQDTNIH CLTIIGQIEGHVQLPPQNKTTKYEHVIPQIVAIEQNPKIEGLLIILNTVGGDVEAGLA IAEMLASLSKPTVSIVLGGGHSIGVPIAVSCDYSYIAETATMTIHPVRLTGLVIGVPQ TFEYLDKMQERVVKFVTSHSNITEEKFKELMFSKGNLTRDIGTNVVGKDAVKYGLIDH AGGVGQAINKLNELIDEARKEEGRMIQ*" gene 1751201..1751938 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" CDS 1751935..1752147 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23927687; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of TepA activity (spore outgrowth)" /protein_id="YP_003097729.1" /db_xref="EnsemblGenomes-Gn:BSU16799" /db_xref="EnsemblGenomes-Tr:CAX52620" /db_xref="InterPro:IPR025619" /db_xref="UniProtKB/Swiss-Prot:C0H413" /translation="MILYTVMPQEIVFAEQNQETSAHEQIEYKGVPLLVEMKGNEAEV IQIMSTNPMHFLHPDISPGQKLKLNV*" gene 1751935..1752147 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" misc_feature 1752175..1752194 /Source="Nicolas_upshift_promotors" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1752189 /Source="Nicolas_upshifts" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" CDS 1752278..1754641 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11062134, 11778051, 12618465, 16430687, 17139259, 17322320, 18160039, 24297254, 24769697, 26452092; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore DNA directional translocase (motor ATPase)" /protein_id="NP_389562.3" /db_xref="EnsemblGenomes-Gn:BSU16800" /db_xref="EnsemblGenomes-Tr:CAB13553" /db_xref="GOA:P21458" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10763" /db_xref="UniProtKB/Swiss-Prot:P21458" /translation="MAKKKRKSRKKQAKQLNIKYELNGLLCIAISIIAILQLGVVGQT FIYLFRFFAGEWFILCLLGLLVLGVSLFWKKKTPSLLTRRKAGLYCIIASILLLSHVQ LFKNLTHKGSIESASVVRNTWELFLMDMNGSSASPDLGGGMIGALLFAASHFLFASTG SQIMAIVMILIGMILVTGRSLQETLKKWMSPIGRFIKEQWLAFIDDMKSFKSNMQSSK KTKAPSKKQKPARKKQQMEPEPPDEEGDYETVSPLIHSEPIISSFSDRNEEEESPVIE KRAEPVSKPLQDIQPETGDQETVSAPPMTFTELENKDYEMPSLDLLADPKHTGQQADK KNIYENARKLERTFQSFGVKAKVTQVHLGPAVTKYEVYPDVGVKVSKIVNLSDDLALA LAAKDIRIEAPIPGKSAIGIEVPNAEVAMVSLKEVLESKLNDRPDAKLLIGLGRNISG EAVLAELNKMPHLLVAGATGSGKSVCVNGIITSILMRAKPHEVKMMMIDPKMVELNVY NGIPHLLAPVVTDPKKASQALKKVVNEMERRYELFSHTGTRNIEGYNDYIKRANNEEG AKQPELPYIVVIVDELADLMMVASSDVEDSITRLSQMARAAGIHLIIATQRPSVDVIT GVIKANIPSRIAFSVSSQTDSRTILDMGGAEKLLGRGDMLFLPVGANKPVRVQGAFLS DDEVEKVVDHVITQQKAQYQEEMIPEETTETHSEVTDELYDEAVELIVGMQTASVSML QRRFRIGYTRAARLIDAMEERGVVGPYEGSKPREVLLSKEKYDELSS*" gene 1752278..1754641 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" S_feature 1754642..1754742 /Source="Nicolas_S_feature" /locus_tag="new_1754642_1754742" /HighExp="Cold, C30, G135, Lbstat, BC, G180, G150, S8, LoTm, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.109246" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S602" promotor_-35 1754703..1754710 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1754725..1754744 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1754743 /Source="Nicolas_upshifts" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" CDS 1754785..1755510 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family,possibly involved in biofilm formation)" /protein_id="NP_389563.1" /db_xref="EnsemblGenomes-Gn:BSU16810" /db_xref="EnsemblGenomes-Tr:CAB13554" /db_xref="GOA:O31761" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13423" /db_xref="UniProtKB/Swiss-Prot:O31761" /translation="MSTKADNRHLYLKVIERIKEDIKNGIYTEKEKLPSEFELSKKLG VSRATLREALRILEEEHVIIRRHGVGTFVHSKPLFLSGIEQLNSVTKMIEQANMTPGT IFLSSQVLMPSEDDTKRFHLAEGQELFYLERVRTADGQPIVYCIDKIPMNILPNSFSH QQESMFDLLEKNSGSVISYAVTDIEPIGYHDTISPVLECDPETALLLLKQTHYDQHDK PVLYSLNYFRADKFRFHVLRKRF*" gene 1754785..1755510 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" downshifts 1755497 /Source="Nicolas_upshifts" /id="D907" /incds=0 /nref=135 /ntot=256 /MaxReadThrough="4.863" /MaxDrop="4.01593" /score="16.3235883" /energy="-7.2" /TU="U1346,U1347" /idTUdmin="U1346" /TUdmin="-88" /isTUend="FALSE" promotor_-35 1755566..1755572 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1755585 /Source="Nicolas_upshifts" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" promotor_-10 1755587..1755598 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1755649..1756857 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" /function="7: Transport and binding proteins" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18502870, 27375568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18502870, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacillibactin exporter" /protein_id="NP_389564.2" /db_xref="EnsemblGenomes-Gn:BSU16825" /db_xref="EnsemblGenomes-Tr:CAB13555" /db_xref="GOA:O31762" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13424" /db_xref="UniProtKB/Swiss-Prot:O31762" /translation="MKNIIALSSVPLVMTLGNSMLIPVLPMMEKKLSVTSFQVSLIIT VYSVVAIICIPIAGYLSDRFGRKKILLPCLLIAGLGGAVAAFASTYMKNPYAMILAGR VLQGIGSAGAAPIVMPFIGDLFKGDDEKVSAGLGDIETANTSGKVLSPILGALLASWY WFVPFWFIPFFCLISFLLVLFLVAKPEEDEDAPAVSEFIKSVKKIFKQDGRWLYTVFI IGCVIMFLLFGVLFYLSDTLENKYAIDGVAKGGLLAIPLLFLSTSSFIAGKKIGKDKG RMKFCVVTGMILLTLSFIALWWNHSFYFLFVFLSFGGIGIGMALPALDALITEGIESE QCGTISSFYNSMRFIGVALGPPVFAALMSNANWIIFILSAFCSIVSLFLVLFTVDAKK SEEEKNLGTV*" gene 1755649..1756857 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" downshifts 1756815 /Source="Nicolas_upshifts" /id="D908" /incds=0 /nref=1 /ntot=32 /MaxReadThrough="1.34389" /MaxDrop="3.00655" /score="5.64651968" /energy="-6.7" /TU="NA" /idTUdmin="U1348" /TUdmin=0 /isTUend="TRUE" promotor_-35 1756926..1756933 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1756946..1756965 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1756968 /Source="Nicolas_upshifts" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" promotor_-35 1756980..1756983 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1756999..1757011 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1757013 /Source="Nicolas_upshifts" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" CDS 1757037..1758317 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metalloprotease" /protein_id="NP_389566.2" /db_xref="EnsemblGenomes-Gn:BSU16845" /db_xref="EnsemblGenomes-Tr:CAB13557" /db_xref="GOA:O31764" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="SubtiList:BG13426" /db_xref="UniProtKB/Swiss-Prot:O31764" /translation="MSYVNELKSKHGGLTAHIVKTEKFKTVSLIFKMLAPLTKDQVTK RALLPHVLLRGTKSHPKTAGLRSYLDELYGTSVSADLTKKGERHVITFRLEIPNEKYL KDQTPLLEKGLQLLAELVFSPALEGDAFQSQYVAQEKRTLKQRIQAVYDDKMRYSNLR LIQEMCKNDPYALHVNGEIDDVDDITAEQLYETYQSAIQKDQLDLYVVGDVDSNQVQS AIDKYFKTEERTLGMIENNHADEKVQPKEVIDEEDVKQGKLNIGYRTSITYTDQDYPA LQVFNGLFGGFSHSKLFINVREKASLAYYAASRIESFKGLLMVMSGIEVKNFEQAVSI IAEQFQAMKNGDFSEQDIAQTKAVIRNQVLETIDTAYGLSEFLYQQAAAQVEIPIEDF LANIENVTKEDIIKAGEKIQLDTTYFLKGTEGAS*" gene 1757037..1758317 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" CDS 1758314..1759600 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative processing protease" /protein_id="NP_389568.2" /db_xref="EnsemblGenomes-Gn:BSU16860" /db_xref="EnsemblGenomes-Tr:CAB13559" /db_xref="GOA:O31766" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG13428" /db_xref="UniProtKB/Swiss-Prot:O31766" /translation="MIKPIEYEQLQETLYHEKMSNGLDVYVLPKKGFNKTYAVFTTKY GSIDNRFVPLGKNEMVHVPDGIAHFLEHKLFEKADGDVFQDFSKQGASANAFTSFTRT AYLFSSTSNVERNLETLIDFVQDPYFTEKTVEKEKGIIGQEINMYDDNPDWRLYFGVI ENMYKEHPVRIDIAGTVESISHITKDLLYECYETFYHPSNMLLFIVGPVDPEAIISQV RENQGKKPYTDQPEIKREEVKEQEAVFRKEKEIKMNVQGPKCLVGLKSKNPFKLGKEL LKHELSMNLLLEALFGKSSAQYESLYEKGYIDETFSFDFTAEYGFGFAAIGGDTPEPD QLAEDISSMLLRAGELITAEKIELARKKKIGTFLKALNSPEYIANQFTRYAFLDMSLF DVVTVLEQITLEDVQNVIQEEIAADRLTVCKVVPKS*" gene 1758314..1759600 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" downshifts 1759450 /Source="Nicolas_upshifts" /id="D909" /incds=1 /nref=10 /ntot=159 /MaxReadThrough="5.673" /MaxDrop="3.16735" /score="1.51160893" /energy="-10.4" /TU="U1349,U1350" /idTUdmin="U1350" /TUdmin="-1256" /isTUend="FALSE" S_feature 1759601..1759654 /Source="Nicolas_S_feature" /locus_tag="new_1759601_1759654" /HighExp="Etha, dia15, H2O2, G135, G150, G180, Paraq, LBGexp, Oxctl, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.431, 0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S603" CDS 1759655..1760383 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15066026, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 28787546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="EF-P-5 aminopentanone reductase (EF-P repair enzyme), NADPH-dependent" /protein_id="NP_389569.2" /db_xref="EnsemblGenomes-Gn:BSU16870" /db_xref="EnsemblGenomes-Tr:CAB13560" /db_xref="GOA:O31767" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13429" /db_xref="UniProtKB/Swiss-Prot:O31767" /translation="MNKTALITGASGGIGKSISETLAARGYNLLLHYNTNQNAAAELA EKLSQMFGVNAEILQADLSAQDGADKLTSSIVQPIDAIVLNSGRSHFGLITDVDNATV QEMVQLHVASPYMLTRNLLPGMIRNKSGAIVAVSSIWGETGASCEVLYSMAKGAQHSF VKGLAKELAPSGIRVNAVAPGAVDTNMMNQFTPAEKEEIADEIPIGRLARPQEIADAT AFLLSEKASYITGQILSVNGGWHC*" gene 1759655..1760383 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" promotor_-35 1760399..1760405 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1760417 /Source="Nicolas_upshifts" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" promotor_-10 1760419..1760430 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1760430) /Source="Nicolas_upshifts" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1760441..1760455) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1760464..1760468) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1760464..1760721 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389570.1" /db_xref="EnsemblGenomes-Gn:BSU16880" /db_xref="EnsemblGenomes-Tr:CAB13561" /db_xref="InterPro:IPR021637" /db_xref="InterPro:IPR024702" /db_xref="SubtiList:BG13430" /db_xref="UniProtKB/Swiss-Prot:O31768" /translation="MSVLENWDSWKNFLGDRLNYAQDKGMSQDTITDLATEIGSYLAN EVESKNEQEKVLADLWSVASKDEQHAIANMMVKLVENNSTH*" gene 1760464..1760721 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" downshifts 1760706 /Source="Nicolas_upshifts" /id="D910" /incds=0 /nref=165 /ntot=250 /MaxReadThrough="4.58488" /MaxDrop="7.23574" /score="21.9507801" /energy="-8.7" /TU="U1349,U1351" /idTUdmin="U1350" /TUdmin=0 /isTUend="TRUE" downshifts complement(1760738) /Source="Nicolas_upshifts" /id="D911" /incds=0 /nref=2 /ntot=15 /MaxReadThrough="3.44398" /MaxDrop="3.96475" /score="-6.33040789" /energy="-7.2" /TU="NA" /idTUdmin="U1344" /TUdmin="-11987" /isTUend="FALSE" promotor_-35 1760779..1760782 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1760797..1760816 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1760797 /Source="Nicolas_upshifts" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" CDS 1760851..1761366 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; N-terminal part of YmfK" /db_xref="SubtiList:BG13431" /translation="MAKLEWYFEYEIQVNRPGLLGDISSLLGMLSINIVTINGVDLSR RGMLLRCRHIDQIKRLESILKTMETIKVTKLREPRLRDRLAVRHGRYIQRDADDKKTF RFERDELGLLVDFMAELFKKEGHKLIGIRGMPRVGKTESIVASSVCEQKVAVCVINLA EADDKKPADCR*" gene 1760851..1761366 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /pseudo CDS 1761302..1761640 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; C-terminal part of YmfK" /db_xref="SubtiList:BG13432" /translation="RWLFVSSTLLKQTIRSQLIADEYSTENVFIVDGIVSTRRGSERH LQLVREIMRLPATKVVEHPDIFVQNTEYTLDDFDYIIELRNDPDEVITYEHAEEPQMF DQSGFSSFDF*" gene 1761302..1761640 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /pseudo CDS 1761707..1762573 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 19164570, 22720735, 23879732, 27415800, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 19164570, 22720735, 23879732, 27415800, 27818647; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell shape determination factor" /protein_id="NP_389573.3" /db_xref="EnsemblGenomes-Gn:BSU16910" /db_xref="EnsemblGenomes-Tr:CAB13564" /db_xref="GOA:O31771" /db_xref="InterPro:IPR025194" /db_xref="SubtiList:BG13433" /db_xref="UniProtKB/Swiss-Prot:O31771" /translation="MSLDDLQAATKIQKRYLTALEEGNYDIIPGKFYVRAFIKQYAEA VGLDADQLFEEHKKDIPNTYHDDVSEKISGMNLQKEMPKPASKALELLPTILVILGVI VVIAIVYAIIQFANHKNSDDHNAASEKAITQSESKYEIPKDSTLKENQNNSSEKETDT KKETKENEDKKKENDSEKLEIKAAGTEGSLTTYEVSGADKIELELKASDSSWIRVRDE NSSSLKEGTLKKDETYKKDITDQKQVDIRTGYAPNLKIKINGKVLSYELDPKKVMAQT IKIVNKKEEKSS*" gene 1761707..1762573 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" promotor_no_box 1761770..1761870 /Source="Nicolas_upshift_promotors" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_no_box" upshifts 1761830 /Source="Nicolas_upshifts" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" downshifts 1762533 /Source="Nicolas_upshifts" /id="D912" /incds=0 /nref=1 /ntot=107 /MaxReadThrough="5.43253" /MaxDrop="2.8328" /score="21.9507801" /energy="-8.7" /TU="U1353,U1354" /idTUdmin="U1351" /TUdmin=0 /isTUend="TRUE" CDS 1762623..1763204 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" /EC_number="2.7.8.5" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15743965, 15849754, 16514141, 16850406, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15743965, 15849754, 16514141, 16850406, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase" /protein_id="NP_389574.2" /db_xref="EnsemblGenomes-Gn:BSU16920" /db_xref="EnsemblGenomes-Tr:CAB13565" /db_xref="GOA:P46322" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004570" /db_xref="SubtiList:BG11373" /db_xref="UniProtKB/Swiss-Prot:P46322" /translation="MFNLPNKITLARIALIPIFMIIMLAPFDWGRLEVGDESIPVAHL AGAILFIIASTTDWVDGYYARKLNLVTNFGKFLDPLADKLLVSAALIILVQFDLAPAW MVIVIISREFAVTGLRLVLAGTGEVVAANMLGKIKTWAQIIAVSALLLHNLPFELVSF PFADLALWVAVFFTVVSGWEYFSKNWEALKTSN*" gene 1762623..1763204 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" CDS 1763222..1764472 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438773, 11703670, 20480359; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence-damage inducible regulator" /protein_id="NP_389575.2" /db_xref="EnsemblGenomes-Gn:BSU16930" /db_xref="EnsemblGenomes-Tr:CAB13566" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008135" /db_xref="InterPro:IPR008136" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036653" /db_xref="SubtiList:BG11374" /db_xref="UniProtKB/Swiss-Prot:P46323" /translation="MEFPKKAEIIAVGSELLLGQIANTNAQFISKQLAEIGVNVFYHT AVGDNPERLKQVIRIAEERSDFIIFSGGLGPTKDDLTKETIANTLGRPLVLNDEAFQS IEDYFKRTKRTMSPNNRKQALVIEGSDVLANHFGMAPGMLTEHESRYYMLLPGPPSEL RPMFENEAKPLLLKKMGSNEKIVSTVLRFFGIGESQLEADLEDIIDAQTNPTIAPLAA DGEVTLRLTAKHADEKETERLLKETEAVILERVGEFFYGYDDTSLVKELSIACKEKGI TISAAESFTGGLFSEWLTDHSGASKLFAGGVVCYTNDVKQNVLGVKKETLDRFGAVSK ECASELAKGVQKLTGSDIGISFTGVAGPDAQEGHEPGHVFIGISANGKEEVHEFHFAG SRTGIRKRGAKYGCHLILKLLEQK*" gene 1763222..1764472 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" S_feature 1764473..1764599 /Source="Nicolas_S_feature" /locus_tag="new_1764473_1764599" /HighExp="LBGstat, LBGtran, G135, Lbstat, G150, C30, LBGexp, dia0, S0, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.016, 0.998" /TUlongSig="SigA" /TUlongPSig="0.987" /label="S604" promotor_-35 1764579..1764586 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1764601..1764620 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1764601 /Source="Nicolas_upshifts" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" CDS 1764645..1765691 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191; Product type f: factor" /codon_start=1 /transl_table=11 /product="multifunctional SOS repair factor" /protein_id="NP_389576.2" /db_xref="EnsemblGenomes-Gn:BSU16940" /db_xref="EnsemblGenomes-Tr:CAB13567" /db_xref="GOA:P16971" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013765" /db_xref="InterPro:IPR020584" /db_xref="InterPro:IPR020587" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR023400" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10721" /db_xref="UniProtKB/Swiss-Prot:P16971" /translation="MSDRQAALDMALKQIEKQFGKGSIMKLGEKTDTRISTVPSGSLA LDTALGIGGYPRGRIIEVYGPESSGKTTVALHAIAEVQQQGGQAAFIDAEHALDPVYA QKLGVNIEELLLSQPDTGEQALEIAEALVRSGAVDIVVVDSVAALVPKAEIEGDMGDS HVGLQARLMSQALRKLSGAINKSKTIAIFINQIREKVGVMFGNPETTPGGRALKFYSS VRLEVRRAEQLKQGNDVMGNKTKIKVVKNKVAPPFRTAEVDIMYGEGISKEGEIIDLG TELDIVQKSGSWYSYEEERLGQGRENAKQFLKENKDIMLMIQEQIREHYGLDNNGVVQ QQAEETQEELEFEE*" gene 1764645..1765691 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" downshifts 1765703 /Source="Nicolas_upshifts" /id="D913" /incds=0 /nref=201 /ntot=262 /MaxReadThrough="4.54659" /MaxDrop="9.405" /score="23.91264" /energy="-9.7" /TU="U1355" /idTUdmin="U1353" /TUdmin="-1" /isTUend="TRUE" S_feature 1765748..1765813 /Source="Nicolas_S_feature" /locus_tag="new_1765748_1765813" /HighExp="S7, S5, S8, S4, H2O2, C30, T5.0H, S6, ferm, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="Sig-, SigA, SigA" /TUlongPSig="0.016, 0.998, 0.987" /label="S605" promotor_-35 1765785..1765794 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1765807..1765822 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1765815 /Source="Nicolas_upshifts" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" CDS 1765859..1767034 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14762009, 15758244, 21856855" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762009, 15758244, 21856855; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding endopeptidase X (lysozyme resistance)" /protein_id="NP_389577.1" /db_xref="EnsemblGenomes-Gn:BSU16950" /db_xref="EnsemblGenomes-Tr:CAB13568" /db_xref="GOA:O31773" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="SubtiList:BG12642" /db_xref="UniProtKB/Swiss-Prot:O31773" /translation="MTSPTRRRTAKRRRRKLNKRGKLLFGLLAVMVCITIWNALHRNS EENEPSQETAAVSNTDQKKEVKKKTAKKSEEQIKTVDRNQKISNYLKEIGFSGTAMIV RNGEIVTNKGFGYADRKHYIQNNPLTSFYVGSSQKALIATAILQLEEKGKLQTSDPVS TYLPHFPNGQTITLKNLLTHTSGINGHIEGNGAITPDDLIKDIELQGIKRQPGVWDYK DSNYSVLAYIIAEVSGEPYEQYIKNHIFKPAGMTHAGFYKTYEKEPYPAVGYKMEGSK TVTPYIPDLSQLYGAGDIYMSAIDMYKFDQALIDGKLYSQKSYEKMFTPGSSSTYGMG FYVAPGSYSNHGVMPGFNILNSFSKSGQTIVILFSNIQNNAKLGQVNNKIYQLLNQE* " gene 1765859..1767034 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" S_feature 1767035..1767134 /Source="Nicolas_S_feature" /locus_tag="new_1767035_1767134" /HighExp="dia0, LBGexp, Lbexp, Oxctl, Paraq, H2O2, C30, G150, Mt0, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.54369999999999996" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA, Sig-, SigA, SigA" /TUlongPSig="1, 0.016, 0.998, 0.987" /label="S606" promotor_-35 1767108..1767115 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1767129..1767148 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" S_feature 1767136..1767309 /Source="Nicolas_S_feature" /locus_tag="new_1767136_1767309" /HighExp="M9-stat, T3.30H, BC, T2.0H, T3.0H, T-1.40H, T1.30H, T2.30H, T4.0H, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S607" upshifts 1767136 /Source="Nicolas_upshifts" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" CDS 1767310..1768872 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" /EC_number="3.1.26.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease Y" /protein_id="NP_389578.1" /db_xref="EnsemblGenomes-Gn:BSU16960" /db_xref="EnsemblGenomes-Tr:CAB13569" /db_xref="GOA:O31774" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR017705" /db_xref="InterPro:IPR022711" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG13420" /db_xref="UniProtKB/Swiss-Prot:O31774" /translation="MTPIMMVLISILLILLGLVVGYFVRKTIAEAKIAGARGAAEQIL EDAKRDAEALKKEALLEAKDEIHKLRIDAEQEVRERRNELQKQENRLLQKEENLDRKH EGIDKREAMLEKKDHSLNERQQHIEEMESKVDEMIRMQQSELERISSLTRDEAKQIIL ERVENELSHDIAIMTKETENRAKEEADKKAKNILSLALQRCAADHVAETTVSVVNLPN DEMKGRIIGREGRNIRTLETLTGIDLIIDDTPEAVILSGFDPIRRETARIALDKLVQD GRIHPARIEEMVEKSRREVDDYIREMGEQTTFEVGVHGLHPDLIKILGRLKFRTSYGQ NVLKHSMEVAFLAGLMASELGEDAKLAKRAGLLHDIGKAIDHEVEGSHVEIGVELATK YKEHPVVINSIASHHGDEEPTSIIAVLVAAADALSAARPGARSETLENYIRRLEKLEE ISESYEGVEKSFAIQAGREVRIMVKPDSINDLEAHRLARDIRKRIEDELDYPGHIKVT VIRETRAVEYAK*" gene 1767310..1768872 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" downshifts 1768849 /Source="Nicolas_upshifts" /id="D914" /incds=0 /nref=243 /ntot=268 /MaxReadThrough="5.32126" /MaxDrop="5.3789" /score="10.4712371" /energy="-9" /TU="U1357" /idTUdmin="U1357" /TUdmin="-1342" /isTUend="FALSE" CDS 1768941..1769735 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19376879, 21856853, 24163345, 26904951, 26906740" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19376879, 21856853, 24163345, 26904951, 26906740; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2'3' and 3'5' cyclic nucleotide monophosphates phosphodiesterase involved in biofilm formation" /protein_id="NP_389579.2" /db_xref="EnsemblGenomes-Gn:BSU16970" /db_xref="EnsemblGenomes-Tr:CAB13570" /db_xref="GOA:O31775" /db_xref="InterPro:IPR005235" /db_xref="InterPro:IPR029052" /db_xref="PDB:4B2O" /db_xref="SubtiList:BG13421" /db_xref="UniProtKB/Swiss-Prot:O31775" /translation="MRILFIGDVVGSPGRDMVKEYVPKLKTKYKPHFTIINGENAAHG KGLTEKIYHSLIQSGADAITMGNHTWDKKEIFDFIDDVPNLVRPANFPEGTPGKGITY VKANGKELAVINLQGRTFLPPLDDPFLKADELIAEAAKRTPYIFIDFHAEATSEKLAL GWYTDGRASAVVGTHTHVQTADNRILPKGTAYITDVGMTGPYDGILGMDRETIIKRFK TNLPVRFTVAEGKTTLSGVVIDIDDQTKKAVKIERILINDDHMFFE*" gene 1768941..1769735 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" promotor_-35 1769490..1769495 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1769511..1769529 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1769531 /Source="Nicolas_upshifts" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" promotor_-35 1769779..1769784 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-35" S_feature 1769795..1769934 /Source="Nicolas_S_feature" /locus_tag="new_1769795_1769934" /HighExp="T5.0H, LoTm, BT, B60, S8, M9-stat, S6, BC, B36, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="0.916, 0.91, 1" /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S608" upshifts 1769795 /Source="Nicolas_upshifts" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" promotor_-10 1769800..1769818 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-10" upshifts complement(1769827) /Source="Nicolas_upshifts" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1769838..1769851) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1769860..1769864) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1769871) /Source="Nicolas_upshifts" /id="D915" /incds=0 /nref=5 /ntot=35 /MaxReadThrough="1.51152" /MaxDrop="3.63977" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=10274 /isTUend="FALSE" CDS 1769935..1770195 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" /function="16.3: Control" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7559352, 16428420, 18562273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559352, 16428420, 18562273; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for dehydratation of the spore core and assembly of the coat (stage V sporulation)" /protein_id="NP_389580.1" /db_xref="EnsemblGenomes-Gn:BSU16980" /db_xref="EnsemblGenomes-Tr:CAB13571" /db_xref="GOA:P45693" /db_xref="InterPro:IPR007347" /db_xref="SubtiList:BG11245" /db_xref="UniProtKB/Swiss-Prot:P45693" /translation="MEILKVSAKSSPNSVAGALAGVLRERGAAEIQAIGAGALNQAVK AVAIARGFVAPSGVDLICIPAFTDIQIDGEERTAIKLIVEPR*" gene 1769935..1770195 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" downshifts 1770147 /Source="Nicolas_upshifts" /id="D916" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="8.31914" /MaxDrop="4.27515" /score="5.18548432" /energy="-12.5" /TU="U1357,U1358,U1359" /idTUdmin="U1357" /TUdmin="-44" /isTUend="FALSE" downshifts complement(1770179) /Source="Nicolas_upshifts" /id="D917" /incds=0 /nref=3 /ntot=15 /MaxReadThrough="1.16149" /MaxDrop="3.88837" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=9966 /isTUend="FALSE" downshifts 1770191 /Source="Nicolas_upshifts" /id="D918" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.08266" /MaxDrop="5.124" /score="5.18548432" /energy="-12.5" /TU="U1358,U1359" /idTUdmin="U1357" /TUdmin=0 /isTUend="TRUE" S_feature 1770236..1770410 /Source="Nicolas_S_feature" /locus_tag="new_1770236_1770410" /HighExp="S6, S8, S7, M9-stat, Lbstat, BT, S5, T1.30H, T2.0H, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.916, 0.91" /TUlongSig="SigA, SigWXY" /TUlongPSig="1, 1" /label="S609" promotor_-35 1770394..1770401 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1770412 /Source="Nicolas_upshifts" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" promotor_-10 1770416..1770435 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1770461..1771504 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" /EC_number="1.1.1.103" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8519804, 16817900, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine 3-dehydrogenase" /protein_id="NP_389581.1" /db_xref="EnsemblGenomes-Gn:BSU16990" /db_xref="EnsemblGenomes-Tr:CAB13572" /db_xref="GOA:O31776" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR004627" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12685" /db_xref="UniProtKB/Swiss-Prot:O31776" /translation="MQSGKMKALMKKDGAFGAVLTEVPIPEIDKHEVLIKVKAASICG TDVHIYNWDQWARQRIKTPYVFGHEFSGIVEGVGENVSSVKVGEYVSAETHIVCGECV PCLTGKSHVCTNTAIIGVDTAGCFAEYVKVPADNIWRNPADMDPSIASIQEPLGNAVH TVLESQPAGGTTAVIGCGPIGLMAVAVAKAAGASQVIAIDKNEYRLRLAKQMGATCTV SIEKEDPLKIVSALTSGEGADLVCEMSGHPSAIAQGLAMAANGGRFHILSLPEHPVTI DLTNKVVFKGLTIQGITGRKMFSTWRQVSQLISSNMIDLAPVITHQFPLEEFEKGFEL MRSGQCGKVILIP*" gene 1770461..1771504 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" CDS 1771517..1772695 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" /EC_number="2.3.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17146529, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-amino-3-ketobutyrate CoA ligase (glycine acetyl transferase)" /protein_id="NP_389582.1" /db_xref="EnsemblGenomes-Gn:BSU17000" /db_xref="EnsemblGenomes-Tr:CAB13573" /db_xref="GOA:O31777" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR010962" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12610" /db_xref="UniProtKB/Swiss-Prot:O31777" /translation="MTKEFEFLKAELNSMKENHTWQDIKQLESMQGPSVTVNHQKVIQ LSSNNYLGFTSHPRLINAAQEAVQQYGAGTGSVRTIAGTFTMHQELEKKLAAFKKTEA ALVFQSGFTTNQGVLSSILSKEDIVISDELNHASIIDGIRLTKADKKVYQHVNMSDLE RVLRKSMNYRMRLIVTDGVFSMDGNIAPLPDIVELAEKYDAFVMVDDAHASGVLGENG RGTVNHFGLDGRVHIQVGTLSKAIGVLGGYAAGSKVLIDYLRHKGRPFLFSTSHPPAV TAACMEAIDVLLEEPEHMERLWENTAYFKAMLVKMGLTLTKSETPILPILIGDEGVAK QFSDQLLSRGVFAQSIVFPTVAKGKARIRTIITAEHTKDELDQALDVIEKTAKELQLL *" gene 1771517..1772695 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" downshifts 1772677 /Source="Nicolas_upshifts" /id="D919" /incds=0 /nref=3 /ntot=25 /MaxReadThrough="5.75732" /MaxDrop="3.4918" /score="4.73069387" /energy="-12.5" /TU="U1361" /idTUdmin="U1359" /TUdmin=1936 /isTUend="FALSE" promotor_-35 1772775..1772778 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1772787 /Source="Nicolas_upshifts" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" promotor_-10 1772793..1772812 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1772843..1774372 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" /EC_number="2.8.4.3" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15175311, 18307109, 20472640, 20584901, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 18307109, 20472640, 20584901, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme for ms(2)i(6)A formation for tRNA modification" /protein_id="NP_389583.1" /db_xref="EnsemblGenomes-Gn:BSU17010" /db_xref="EnsemblGenomes-Tr:CAB13574" /db_xref="GOA:O31778" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006463" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="SubtiList:BG13418" /db_xref="UniProtKB/Swiss-Prot:O31778" /translation="MNEKQKLESGQVHPSDKKSEKDYSKYFEAVYIPPSLKDAKKRGK EAVTYHNDFKISEQFKGLGDGRKFYIRTYGCQMNEHDTEVMAGIFMALGYEATNSVDD ANVILLNTCAIRENAENKVFGELGHLKALKKNNPDLILGVCGCMSQEESVVNRILKKH PFVDMIFGTHNIHRLPELLSEAYLSKEMVVEVWSKEGDVIENLPKVRNGKIKGWVNIM YGCDKFCTYCIVPYTRGKERSRRPEDIIQEVRRLASEGYKEITLLGQNVNAYGKDFED MTYGLGDLMDELRKIDIPRIRFTTSHPRDFDDRLIEVLAKGGNLLDHIHLPVQSGSSE VLKLMARKYDRERYMELVRKIKEAMPNASLTTDIIVGFPNETDEQFEETLSLYREVEF DSAYTFIYSPREGTPAAKMKDNVPMRVKKERLQRLNALVNEISAKKMKEYEGKVVEVL VEGESKNNPDILAGYTEKSKLVNFKGPKEAIGKIVRVKIQQAKTWSLDGEMVGEAIEV K*" gene 1772843..1774372 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" CDS 1774374..1774805 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator for biofilm formation via regulation of RNase Y (RicAFT complex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389584.1" /db_xref="EnsemblGenomes-Gn:BSU17020" /db_xref="EnsemblGenomes-Tr:CAB13575" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR016783" /db_xref="InterPro:IPR023378" /db_xref="PDB:2PIH" /db_xref="SubtiList:BG13417" /db_xref="UniProtKB/Swiss-Prot:O31779" /translation="MTLYSKKDIVQQARNLAKMISETEEVDFFKRAEAQINENDKVST IVNQIKALQKQAVNLKHYEKHEALKQVEAKIDALQEELEEIPVIQEFRDSQMEVNDLL QLVAHTISNQVTNEIITSTGGDLLKGETGSKVKHSNNSCSL*" gene 1774374..1774805 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" downshifts 1774788 /Source="Nicolas_upshifts" /id="D920" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="0.9572" /MaxDrop="7.73043" /score="21.1260722" /energy="-10.3" /TU="NA" /idTUdmin="U1361" /TUdmin="-1" /isTUend="TRUE" promotor_-35 1774936..1774941 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1774957..1774975 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1774965..1775066 /Source="Nicolas_S_feature" /locus_tag="new_1774965_1775066" /HighExp="S3, S5, S8, S4, S6, S7, B36, BT, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S610" upshifts 1774965 /Source="Nicolas_upshifts" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" CDS 1775067..1775612 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenic spore protein" /protein_id="NP_389585.1" /db_xref="EnsemblGenomes-Gn:BSU17030" /db_xref="EnsemblGenomes-Tr:CAB13576" /db_xref="GOA:P14016" /db_xref="InterPro:IPR018901" /db_xref="SubtiList:BG10494" /db_xref="UniProtKB/Swiss-Prot:P14016" /translation="MSEYREIITKAVVAKGRKFTQCTNTISPEKKPSSILGGWIINHK YDAEKIGKTVEIEGYYDINVWYSYADNTKTEVVTERVKYVDVIKLRYRDNNYLDDEHE VIAKVLQQPNCLEVTISPNGNKIVVQAEREFLAEVVGETKVVVEVNPDWEEDDEEDWE DELDEELEDINPEFLVGDPEE*" gene 1775067..1775612 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" downshifts 1775606 /Source="Nicolas_upshifts" /id="D921" /incds=0 /nref=64 /ntot=97 /MaxReadThrough="4.37388" /MaxDrop="8.23792" /score="10.7927556" /energy="-12.6" /TU="U1363" /idTUdmin="U1363" /TUdmin="-745" /isTUend="FALSE" downshifts complement(1775613) /Source="Nicolas_upshifts" /id="D922" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="4.21458" /MaxDrop="3.44208" /score="12.3953461" /energy="-11.4" /TU="NA" /idTUdmin="U1366" /TUdmin=4532 /isTUend="FALSE" promotor_-35 1775670..1775673 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1775688..1775707 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1775692 /Source="Nicolas_upshifts" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" CDS 1775745..1778321 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" /function="16.5: Explore" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15375129, 16269814, 23998896, 26343983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 16269814, 23998896, 26343983; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA mismatch repair recognition factor" /protein_id="NP_389586.2" /db_xref="EnsemblGenomes-Gn:BSU17040" /db_xref="EnsemblGenomes-Tr:CAB13577" /db_xref="GOA:P49849" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR005748" /db_xref="InterPro:IPR007695" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR007860" /db_xref="InterPro:IPR007861" /db_xref="InterPro:IPR016151" /db_xref="InterPro:IPR017261" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036187" /db_xref="InterPro:IPR036678" /db_xref="SubtiList:BG11403" /db_xref="UniProtKB/Swiss-Prot:P49849" /translation="MAGYTPMIQQYLKIKAEHQDAFLFFRLGDFYEMFFEDAKKASQE LEITLTSRDGGAAEKIPMCGVPYHSASAYIEQLIKKGYKVAICEQTEDPKAAKGVVKR EVVQLITPGTVMDGKGIHESENNFIASVSACSNGYGLALSDLTTGENLAVLIERLEDV ISEIYSVGAREIVVSGSLDADTVAQLRERCGATISIEDGETDEHVTIIEHLNNEDITK TFLRLYTYLKRTQKRSLDHLQPVQVYELEEAMKIDLYSKRNLELTETIRSKNKKGSLL WLLDETKTAMGGRLLKQWIDRPLIRVNQIEERQEMVETLMSHFFEREDLRERLKEVYD LERLAGRVAFGNVNARDLIQLKESLKQVPGIKQLVASLAHDKAKERAKRIDPCGDVLE LLEEALYENPPLSVKEGNLIKDGYNQKLDEYRDASRNGKDWIARLEQQEREYTGIRSL KVGFNKVFGYYIEVTKANLHLLEEGRYERKQTLTNAERYITPELKEKEALILEAENNI CELEYELFTELREKVKQYIPRLQQLAKQMSELDALQCFATISENRHYTKPEFSKDEVE VIEGRHPVVEKVMDSQEYVPNNCMMGDNRQMLLITGPNMSGKSTYMRQIALISIMAQI GCFVPAKKAVLPIFDQIFTRIGAADDLISGQSTFMVEMLEAKNAIVNATKNSLILFDE IGRGTSTYDGMALAQAIIEYVHDHIGAKTLFSTHYHELTVLEDKLPQLKNVHVRAEEY NGTVVFLHQIKEGAADKSYGIHVAQLAELPGDLIARAQDILKELEHSGNKPEVPVQKP QVKEEPAQLSFFDEAEKPAETPKLSKKEKQVIDAFKSLNILDMTPLEAMNEMYKLQKK LH*" gene 1775745..1778321 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" CDS 1778337..1780220 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15375129, 22843852, 26343983, 26384423, 27369079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 22843852, 26343983, 26384423, 27369079; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA mismatch repair endonuclease" /protein_id="NP_389587.1" /db_xref="EnsemblGenomes-Gn:BSU17050" /db_xref="EnsemblGenomes-Tr:CAB13578" /db_xref="GOA:P49850" /db_xref="InterPro:IPR002099" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR013507" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR014762" /db_xref="InterPro:IPR014790" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020667" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037198" /db_xref="PDB:3GAB" /db_xref="PDB:3KDG" /db_xref="PDB:3KDK" /db_xref="SubtiList:BG11402" /db_xref="UniProtKB/Swiss-Prot:P49850" /translation="MAKVIQLSDELSNKIAAGEVVERPASVVKELVENAIDADSTVIE IDIEEAGLASIRVLDNGEGMENEDCKRAFRRHATSKIKDENDLFRVRTLGFRGEALPS IASVSHLEITTSTGEGAGTKLVLQGGNIISESRSSSRKGTEIVVSNLFFNTPARLKYM KTVHTELGNITDVVNRIALAHPEVSIRLRHHGKNLLQTNGNGDVRHVLAAIYGTAVAK KMLPLHVSSLDFEVKGYIALPEITRASRNYMSSVVNGRYIKNFPLVKAVHEGYHTLLP IGRHPITFIEITMDPILVDVNVHPSKLEVRLSKETELHDLIRDGIKDVFKQQQLIPSA QVPKKSAPAIKNEQQFITFDEKPPEKKVPEKSTAPSYSPMKLSSVVKEPVDAEEKLPP LQFDAPPIVDQEQTLEVSDVSAEQPETFEQECHEEQPQPASDRVPIMYPIGQMHGTYI LAQNENGLYIIDQHAAQERIKYEYFREKVGEVEPEVQEMIVPLTFHYSTNEALIIEQH KQELESVGVFLESFGSNSYIVRCHPAWFPKGEEAELIEEIIQQVLDSKNIDIKKLREE AAIMMSCKGSIKANRHLRNDEIKALLDDLRSTSDPFTCPHGRPIIIHHSTYEMEKMFK RVM*" gene 1778337..1780220 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" S_feature complement(1780123..1780617) /Source="Nicolas_S_feature" /locus_tag="new_1780123_1780617_c" /HighExp="M9-stat, LBGstat, LPhT, T2.0H, Lbstat, C30, T2.30H, M0t90, T1.30H, HiOs" /AntisenseName="mutL" /AntisenseCor="0.27126904061692803" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S611" downshifts 1780135 /Source="Nicolas_upshifts" /id="D923" /incds=1 /nref=216 /ntot=257 /MaxReadThrough="2.0064" /MaxDrop="5.37369" /score="33.4967163" /energy="-18.6" /TU="NA" /idTUdmin="U1364" /TUdmin=0 /isTUend="TRUE" downshifts complement(1780145) /Source="Nicolas_upshifts" /id="D924" /incds=1 /nref=3 /ntot=100 /MaxReadThrough="1.93338" /MaxDrop="2.7192" /score="27.1353816" /energy="-13.5" /TU="NA" /idTUdmin="U1366" /TUdmin=0 /isTUend="TRUE" promotor_-35 1780367..1780374 /Source="Nicolas_upshift_promotors" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1780389..1780408 /Source="Nicolas_upshift_promotors" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1780399..1780532 /Source="Nicolas_S_feature" /locus_tag="new_1780399_1780532" /HighExp="LoTm, T0.30H, T1.30H, M9-stat, T3.0H, BC, T1.0H, B60, B36, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99494800000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S612" upshifts 1780399 /Source="Nicolas_upshifts" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" misc_RNA complement(1780404..1780554) /gene="surX" /locus_tag="BSU_misc_RNA_89" /product="small untranslated RNA of unknown function" /note="Evidence 5: Unknown function; PubMedId : 20525796, 23155385" gene complement(1780404..1780554) /gene="surX" /locus_tag="BSU_misc_RNA_89" downshifts 1780489 /Source="Nicolas_upshifts" /id="D925" /incds=0 /nref=19 /ntot=136 /MaxReadThrough="3.45962" /MaxDrop="4.12444" /score="29.4045648" /energy="-15.3" /TU="U1365" /idTUdmin="U1364" /TUdmin=354 /isTUend="FALSE" CDS complement(1780618..1781073) /gene="ymzD" /locus_tag="BSU_17060" /old_locus_tag="BSU17060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="YP_054578.1" /db_xref="EnsemblGenomes-Gn:BSU17060" /db_xref="EnsemblGenomes-Tr:CAE01453" /db_xref="GOA:Q7WY71" /db_xref="InterPro:IPR025912" /db_xref="SubtiList:BG14188" /db_xref="UniProtKB/Swiss-Prot:Q7WY71" /translation="MNQKEQNEHSKDFNLRSKLIGIVSITFIAAIALAVIFGGFFFGM KGLFSILGITYASNQTLALFILACFAVGLIIDPLTKIISIILAKSLSLKKTALFAFIL YFISNLITICFADYFMQSIYIPDVLLVVISAFMAIIELAFDNQPNREAA*" gene complement(1780618..1781073) /gene="ymzD" /locus_tag="BSU_17060" /old_locus_tag="BSU17060" S_feature complement(1781074..1781165) /Source="Nicolas_S_feature" /locus_tag="new_1781074_1781165_c" /HighExp="LBGstat, M9-stat, T1.0H, T1.30H, T2.0H, M0t90, MG 150, LPhT, T3.0H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S613" promotor_-10 complement(1781153..1781172) /Source="Nicolas_upshift_promotors" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1781165) /Source="Nicolas_upshifts" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" promotor_-35 complement(1781189..1781192) /Source="Nicolas_upshift_promotors" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1781228..1781785) /gene="ymcC" /locus_tag="BSU_17070" /old_locus_tag="BSU17070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389588.1" /db_xref="EnsemblGenomes-Gn:BSU17070" /db_xref="EnsemblGenomes-Tr:CAB13579" /db_xref="GOA:O31780" /db_xref="SubtiList:BG13419" /db_xref="UniProtKB/Swiss-Prot:O31780" /translation="MNGIAWMIVFCEIAFWVVIVLGLAVRYVFKRHTLGLLFLALTPV IDLILLAATGVDLYRGASATAAHGIAAVYIGISIAYGKQMIQWADEKFQYYVTKKGTK PLKRFGMDHAKHGAKGWLRHVLAYLIGAGLLAGMIYFINDSSRTEALSGILKLWTVII GIDFLITASYFIWPKKEKASANLRS*" gene complement(1781228..1781785) /gene="ymcC" /locus_tag="BSU_17070" /old_locus_tag="BSU17070" promotor_-35 1781869..1781876 /Source="Nicolas_upshift_promotors" /id="U1367" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.404595404595405" /psig=1 /xcortree=3145 /SigmaFactorBS="ccatctttgtttttgtaacacaactgtattataaaAATTGCC CtctcatttttttCTTGTTACAATAAAGCTATGccaaaacaaattgaccatgagaaaa g" /listShort="pksA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1781889..1781908 /Source="Nicolas_upshift_promotors" /id="U1367" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.404595404595405" /psig=1 /xcortree=3145 /SigmaFactorBS="ccatctttgtttttgtaacacaactgtattataaaAATTGCC CtctcatttttttCTTGTTACAATAAAGCTATGccaaaacaaattgaccatgagaaaa g" /listShort="pksA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1781891..1781909) /Source="Nicolas_upshift_promotors" /id="U1368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1400 /SigmaFactorBS="gcgccacgttgcttctgcaatttgttttcttcttttCTCATG gtcaatttgttttgGCATAGCTTTATTGTAACAagaaaaaaatgagagggcaattttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1781894 /Source="Nicolas_upshifts" /id="U1367" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.404595404595405" /psig=1 /xcortree=3145 /SigmaFactorBS="ccatctttgtttttgtaacacaactgtattataaaAATTGCC CtctcatttttttCTTGTTACAATAAAGCTATGccaaaacaaattgaccatgagaaaa g" /listShort="pksA" /GFF_Attribute="listLong" upshifts complement(1781905) /Source="Nicolas_upshifts" /id="U1368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1400 /SigmaFactorBS="gcgccacgttgcttctgcaatttgttttcttcttttCTCATG gtcaatttgttttgGCATAGCTTTATTGTAACAagaaaaaaatgagagggcaattttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1781906..1782523 /gene="pksA" /locus_tag="BSU_17080" /old_locus_tag="BSU17080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17234808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17234808; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of bacillaene synthesis operon" /protein_id="NP_389589.1" /db_xref="EnsemblGenomes-Gn:BSU17080" /db_xref="EnsemblGenomes-Tr:CAB13580" /db_xref="GOA:O34381" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12647" /db_xref="UniProtKB/Swiss-Prot:O34381" /translation="MPKQIDHEKRRKQIAEATWRVILERGMEGASARNIAKEAGLSLG ALRHYFSTQDELLAFAMKLVQEKVTDRIKDIAVRDLLPKEKVLQILLEMVPTNEETIR EMEVWFAFTAYARHKKDMFDASHDGIFSGMRNLIAYLDESDLLKQNADKDIEAERLYA LVDGLALHAMLDPVRVNKDRIKRVIMQHVESICVEDTRETQKRHP*" gene 1781906..1782523 /gene="pksA" /locus_tag="BSU_17080" /old_locus_tag="BSU17080" promotor_-35 complement(1781924..1781929) /Source="Nicolas_upshift_promotors" /id="U1368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1400 /SigmaFactorBS="gcgccacgttgcttctgcaatttgttttcttcttttCTCATG gtcaatttgttttgGCATAGCTTTATTGTAACAagaaaaaaatgagagggcaattttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1782511 /Source="Nicolas_upshifts" /id="D926" /incds=0 /nref=121 /ntot=233 /MaxReadThrough="1.91611" /MaxDrop="4.92546" /score="24.8248143" /energy="-17.1" /TU="NA" /idTUdmin="U1367" /TUdmin=0 /isTUend="TRUE" misc_feature 1782630..1782649 /Source="Nicolas_upshift_promotors" /id="U1369" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95904095904096" /psig="0.999000999001" /xcortree=2952 /SigmaFactorBS="tttcaaagaacaaggatctctgaaaaaaatggaaaacaatca tgctgTTTGGTAAAGTGGAATGAAAgacggactgaggggtgaacactggtccatcgtt t" /listShort="S614, pksB, S615" /listLong="S616, pksC, S617, pksD, pksE, acpK, pksF, pksG, pksH, pksI, pksJ, pksL, pksM, pksN, pksR" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1782643..1782712 /Source="Nicolas_S_feature" /locus_tag="new_1782643_1782712" /HighExp="T3.0H, HiOs, T2.30H, T2.0H, BC, T3.30H, M9-tran, MG 150, M0t90, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S614" upshifts 1782643 /Source="Nicolas_upshifts" /id="U1369" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95904095904096" /psig="0.999000999001" /xcortree=2952 /SigmaFactorBS="tttcaaagaacaaggatctctgaaaaaaatggaaaacaatca tgctgTTTGGTAAAGTGGAATGAAAgacggactgaggggtgaacactggtccatcgtt t" /listShort="S614, pksB, S615" /listLong="S616, pksC, S617, pksD, pksE, acpK, pksF, pksG, pksH, pksI, pksJ, pksL, pksM, pksN, pksR" CDS 1782713..1783390 /gene="pksB" /locus_tag="BSU_17090" /old_locus_tag="BSU17090" /EC_number="3.1.2.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17234808, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase involved in bacillaene synthesis" /protein_id="NP_389590.1" /db_xref="EnsemblGenomes-Gn:BSU17090" /db_xref="EnsemblGenomes-Tr:CAB13581" /db_xref="GOA:O34769" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12648" /db_xref="UniProtKB/Swiss-Prot:O34769" /translation="MNLTYKVHPIKTRYQGWTNYCYIIEDIVSRSAIVVDPSWELSKI TTTLSELEAELKAVALTHSHYDHVNLVDPLTKMFNAQVYMSKKEIDYYQFRCRNLISL DDHQTISIGNTRAQCLLTPGHTAGGMCYLFSESIFTGDTVFTEGCGICEDDGSSAEEM FDSIQRIKSEVSPHVRVYPGHSFGKSPGHSIKDLYQHNIYFQIDKKEYFVKFRTRKNQ KGIFDFK*" gene 1782713..1783390 /gene="pksB" /locus_tag="BSU_17090" /old_locus_tag="BSU17090" S_feature 1783391..1783658 /Source="Nicolas_S_feature" /locus_tag="new_1783391_1783658" /HighExp="HiOs, T2.0H, M0t90, S2, S1, T4.0H, T-5.40H, Lbstat, M9-tran, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S615" CDS 1783500..1783766 /locus_tag="BSU_17099" /old_locus_tag="BSU17099" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513956.1" /translation="MKRIIMIWRPICNPGLFSYVLLYLLILYSSMEKSRKTMEQTVGK INLTDNIYRGYHQHEHATIYPVITIIKSYRSETHLLIGRVALRE*" gene 1783500..1783766 /locus_tag="BSU_17099" /old_locus_tag="BSU17099" promotor_-35 1783635..1783642 /Source="Nicolas_upshift_promotors" /id="U1370" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.993006993006993" /xcortree=556 /SigmaFactorBS="gcagaaaaacaatggagcaaactgtaggaaaaattAACTTGA CggataatatttacaGAGGTTACCATCAACATGAAcatgctactatttatccggtcat c" /listShort="S616, pksC, S617, pksD, pksE, acpK, pksF, pksG, pksH, pksI, pksJ, pksL, pksM, pksN, pksR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1783657..1783676 /Source="Nicolas_upshift_promotors" /id="U1370" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.993006993006993" /xcortree=556 /SigmaFactorBS="gcagaaaaacaatggagcaaactgtaggaaaaattAACTTGA CggataatatttacaGAGGTTACCATCAACATGAAcatgctactatttatccggtcat c" /listShort="S616, pksC, S617, pksD, pksE, acpK, pksF, pksG, pksH, pksI, pksJ, pksL, pksM, pksN, pksR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1783660..1783762 /Source="Nicolas_S_feature" /locus_tag="new_1783660_1783762" /HighExp="S2, M0t90, M9-stat, HiOs, Lbstat, BC, M40t90, T2.30H, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.62175899999999995" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S616" upshifts 1783660 /Source="Nicolas_upshifts" /id="U1370" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.993006993006993" /xcortree=556 /SigmaFactorBS="gcagaaaaacaatggagcaaactgtaggaaaaattAACTTGA CggataatatttacaGAGGTTACCATCAACATGAAcatgctactatttatccggtcat c" /listShort="S616, pksC, S617, pksD, pksE, acpK, pksF, pksG, pksH, pksI, pksJ, pksL, pksM, pksN, pksR" /GFF_Attribute="listLong" CDS 1783763..1784629 /gene="pksC" /locus_tag="BSU_17100" /old_locus_tag="BSU17100" /EC_number="2.3.1.39" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16707694, 16757561, 17234808, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707694, 16757561, 17234808, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malonyl-CoA-acyltransferase involved in bacillaene synthesis" /protein_id="NP_389591.1" /db_xref="EnsemblGenomes-Gn:BSU17100" /db_xref="EnsemblGenomes-Tr:CAB13582" /db_xref="GOA:O34825" /db_xref="InterPro:IPR004410" /db_xref="InterPro:IPR014043" /db_xref="InterPro:IPR016035" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR020801" /db_xref="InterPro:IPR024925" /db_xref="PDB:5DZ6" /db_xref="SubtiList:BG12649" /db_xref="UniProtKB/Swiss-Prot:O34825" /translation="MITYVFPGQGSQKQGMGSGLFDEFKELTDQADEILGYSIKRLCL ENPYSNLNKTQFTQPALYVVNALSYLKKIRDEEVKPDFVAGHSLGEYNALFAAEAFDF ETGLQLVRKRGELMSLISNGGMAAVMGLNEEQVAKALKEYHLHDVDIANVNAPYQIVI SGKKDEIEKAASLFETMTEVTMVLPLNVSGAFHSRYMNKAKEEFEEFLHAFYFSPPSI PVISNVYAKPYTYEFMKQTLADQINHSVKWTDSISYLMKKGHMEFEEVGPGNVLTGLI HRIKKDAEAMPR*" gene 1783763..1784629 /gene="pksC" /locus_tag="BSU_17100" /old_locus_tag="BSU17100" S_feature 1784630..1785132 /Source="Nicolas_S_feature" /locus_tag="new_1784630_1785132" /HighExp="S2, Lbstat, M0t90, M40t90, S1, T1.0H, HiOs, T2.30H, M9-tran, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S617" CDS 1785133..1786107 /gene="pksD" /locus_tag="BSU_17110" /old_locus_tag="BSU17110" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16707694, 17234808, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme involved in bacillaene synthesis" /protein_id="NP_389592.2" /db_xref="EnsemblGenomes-Gn:BSU17110" /db_xref="EnsemblGenomes-Tr:CAB13583" /db_xref="GOA:O34877" /db_xref="InterPro:IPR014043" /db_xref="InterPro:IPR016035" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR020801" /db_xref="SubtiList:BG12650" /db_xref="UniProtKB/Swiss-Prot:O34877" /translation="MNEPLVFMFSGQGSQYYHMGKELFKENTVFRQSMLEMDAIAARR IGTSIVEEIYHPGKRVSDPFDSILFSHPAIFMIEYSLYKVLEDRGIYPDYVLGSSLGE FAAAAVSGVSDAEDMLDCILEQAIIIQNSCDKGKMLAILDKPQLLNDHPQLFGNSELI SINYDSHFVISGEEDHIRKIMEDLKEKQILCQLLPVSYAFHSSLIDPAESAYAEFLRS KSFQKPSIPIVSSLTGSCLHVMDENFFWNAVRKPMMFREAIRYLESQHTCKFIDLGPS GTLAAFVKQLIPGDSADRCCSIITPFHQELKNLNTVEYFRTPERKFTR*" gene 1785133..1786107 /gene="pksD" /locus_tag="BSU_17110" /old_locus_tag="BSU17110" CDS 1786104..1788407 /gene="pksE" /locus_tag="BSU_17120" /old_locus_tag="BSU17120" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16707694, 17234808, 22720735, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme involved in bacillaene synthesis" /protein_id="NP_389593.3" /db_xref="EnsemblGenomes-Gn:BSU17120" /db_xref="EnsemblGenomes-Tr:CAB13584" /db_xref="GOA:O34787" /db_xref="InterPro:IPR004136" /db_xref="InterPro:IPR004410" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014043" /db_xref="InterPro:IPR014179" /db_xref="InterPro:IPR016035" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR020801" /db_xref="PDB:5DZ7" /db_xref="SubtiList:BG12651" /db_xref="UniProtKB/Swiss-Prot:O34787" /translation="MITYVFPGQGSQQKGMGQGLFEQYQHLTDQADQILGYSIEKLCT EKSYLDVNHTEYTQPALYVVNALSYLKRVEETGRKPDFAAGHSLGEYNALMAAGAFDF ETGLRLVKKRGELMGRITGGGMAAVIGLSKEQVTAVLEEHRLYDIDVANENTPQQIVI SGPKKEIEKARAVFENTKDVKLFHPLNVSGAFHSRYMNEAKQVFKQYIDSFQFAPLAI PVISNVYAEPYHQDRLKDTLSEQMDNTVKWTDSIRFLMGRGEMEFAEIGPGTVLTGLI HRIKNEAEPLTYIPKKNPAISAHLKEQRNVQAGITAESLGSAEFKQDYHLTYAYLAGG MYRGIASKEMVVKLSRAGMMGFFGTGGLSLKEVEDAIHAIQGELGKGQAYGINLVHNM KHTESEEKMIDLLLRNQVSIVEASAFLSVTPVLVRYRAKGVKRNQNGDVICSNRLIAK ISRPEVAESFLSPAPENMLQKLLGENKITMNEAELLRCIPMADDICVEADSGGHTDGG VAYSLMPAMTSLRDEMMKKYQYRKKIRVGAAGGIGTPEAAMAAFMLGADFILTGSINQ CTVEAATSDKVKDLLQQMNVQDTAYAPAGDMFESGSKVQVLKKGVFFPARANKLYELY QRYGSIRELDAKMLAQLEEKYFKRSIEDIYKDIALHYPAADIEKAEQNPKHKMALIFR WYFRYSSKLAISGSEHSKVDYQIHCGPALGAFNQWVKGSQLENWRNRHVDEIGKKLMT ETAVLLHERMQSMYQPSHETDNIKIKV*" gene 1786104..1788407 /gene="pksE" /locus_tag="BSU_17120" /old_locus_tag="BSU17120" CDS 1788469..1788717 /gene="acpK" /locus_tag="BSU_17130" /old_locus_tag="BSU17130" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16707694, 16757561, 17234808, 26284661; Product type c: carrier" /codon_start=1 /transl_table=11 /product="acyl-carrier protein involved in bacillaene synthesis" /protein_id="NP_570904.1" /db_xref="EnsemblGenomes-Gn:BSU17130" /db_xref="EnsemblGenomes-Tr:CAE01454" /db_xref="GOA:Q7PC63" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG14186" /db_xref="UniProtKB/Swiss-Prot:Q7PC63" /translation="MDKQRIFEVLITNICEVLPELDGHRFEPEDQLVELGADSVDRAE IITMVLEDLSLKIPRIELSGVKNIGELAEVLYDKVQSA*" gene 1788469..1788717 /gene="acpK" /locus_tag="BSU_17130" /old_locus_tag="BSU17130" CDS 1788695..1789942 /gene="pksF" /locus_tag="BSU_17140" /old_locus_tag="BSU17140" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16757561, 17234808, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16757561, 17234808, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="decarboxylase converting malonyl-S-AcpK to acetyl-S-AcpK for bacillaene-related polyketide synthesis" /protein_id="NP_389594.2" /db_xref="EnsemblGenomes-Gn:BSU17140" /db_xref="EnsemblGenomes-Tr:CAB13585" /db_xref="GOA:P40804" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020841" /db_xref="SubtiList:BG10925" /db_xref="UniProtKB/Swiss-Prot:P40804" /translation="MTKCNLPEVVVTGVGVTASIGQGKEDFASSLLSGRHAFDVMKRS GRQKDSRFIGAEIASLSYPDRLSKKMLRKASFSSRAALVTLTEAWEEAELDDADSSRI GLVVGGSNFQQRENFEVYERYQDRSGFISPAYGLSFMDSDLCGICTDQFGITGLAYTV GGASASGQLAVIHAIQQVLSGEVDTCIALGALMDLSYMECEALRALGAMGTDKYADEP ENACRPFDQNRDGFIYGESCGALVIERKETALRRGLKPYAALSGWSIKLDGNRNPDPS LEGEIHVIQKALERARLLPEDIDYINPHGTGSFIGDEIELKALRACRLSHAYINATKS ITGHGLSAAGIVEIISVLLQMKKSALHPSRNLDHPIDDSFHWVNEKSISYRIKNALSL SMGFGGMNTAVCIQNIEKCGGES*" gene 1788695..1789942 /gene="pksF" /locus_tag="BSU_17140" /old_locus_tag="BSU17140" CDS 1789943..1791205 /gene="pksG" /locus_tag="BSU_17150" /old_locus_tag="BSU17150" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16707694, 16757561, 17234808, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-S-AcpK beta-ketothioester bacillaene intermediate transferase" /protein_id="NP_389595.2" /db_xref="EnsemblGenomes-Gn:BSU17150" /db_xref="EnsemblGenomes-Tr:CAB13586" /db_xref="GOA:P40830" /db_xref="InterPro:IPR013528" /db_xref="InterPro:IPR013746" /db_xref="InterPro:IPR016039" /db_xref="PDB:4YXQ" /db_xref="PDB:4YXT" /db_xref="PDB:4YXV" /db_xref="SubtiList:BG10926" /db_xref="UniProtKB/Swiss-Prot:P40830" /translation="MVSAGIEAMNVFGGTAYLDVMELAKYRHLDTARFENLLMKEKAV ALPYEDPVTFGVNAAKPIIDALSEAEKDRIELLITCSESGIDFGKSLSTYIHEYLGLN RNCRLFEVKQACYSGTAGFQMAVNFILSQTSPGAKALVIASDISRFLIAEGGDALSED WSYAEPSAGAGAVAVLVGENPEVFQIDPGANGYYGYEVMDTCRPIPDSEAGDSDLSLM SYLDCCEQTFLEYQKRVPGANYQDTFQYLAYHTPFGGMVKGAHRTMMRKVAKVKTSGI ETDFLTRVKPGLNYCQRVGNIMGAALFLALASTIDQGRFDTPKRIGCFSYGSGCCSEF YSGITTPQGQERQRTFGIEKHLDRRYQLSMEEYELLFKGSGMVRFGTRNVKLDFEMIP GIMQSTQEKPRLFLEEISEFHRKYRWIS*" gene 1789943..1791205 /gene="pksG" /locus_tag="BSU_17150" /old_locus_tag="BSU17150" CDS 1791193..1791972 /gene="pksH" /locus_tag="BSU_17160" /old_locus_tag="BSU17160" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16707694, 16757561, 17234808, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-CoA hydratase for bacillaene biosynthesis" /protein_id="NP_389596.1" /db_xref="EnsemblGenomes-Gn:BSU17160" /db_xref="EnsemblGenomes-Tr:CAB13587" /db_xref="GOA:P40805" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="PDB:3HP0" /db_xref="SubtiList:BG10927" /db_xref="UniProtKB/Swiss-Prot:P40805" /translation="MDLVTYQTIKVRFQASVCYITFHRPEANNTINDTLIEECLQVLN QCETSTVTVVVLEGLPEVFCFGADFQEIYQEMKRGRKQASSQEPLYDLWMKLQTGPYV TISHVRGKVNAGGLGFVSATDIAIADQTASFSLSELLFGLYPACVLPFLIRRIGRQKA HYMTLMTKPISVQEASEWGLIDAFDAESDVLLRKHLLRLRRLNKKGIAHYKQFMSSLD HQVSRAKATALTANQDMFSDPQNQMGIIRYVETGQFPWEDQ*" gene 1791193..1791972 /gene="pksH" /locus_tag="BSU_17160" /old_locus_tag="BSU17160" CDS 1792012..1792761 /gene="pksI" /locus_tag="BSU_17170" /old_locus_tag="BSU17170" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16707694, 16757561, 17234808, 22720735, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="decarboxylase involved in bacillaene synthesis" /protein_id="NP_389597.2" /db_xref="EnsemblGenomes-Gn:BSU17170" /db_xref="EnsemblGenomes-Tr:CAB13588" /db_xref="GOA:P40802" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="PDB:4Q1G" /db_xref="PDB:4Q1H" /db_xref="PDB:4Q1I" /db_xref="PDB:4Q1J" /db_xref="PDB:4Q1K" /db_xref="SubtiList:BG10928" /db_xref="UniProtKB/Swiss-Prot:P40802" /translation="MTHSVVELIEIESAIIQVKMQDRTHKNAFSQELTDDLIQAFEYI RQNPKYKAVILTGYDNYFASGGTQEGLLRIQQGLTKFTDDNLYSLALDCEIPVIAAMQ GHGIGGGFVMGLFADIVILSRESVYTANFMKYGFTPGMGATFIVPKKLGFSLAQEILL NAGSYRGADLEKRGVPFKVLPRAEVLDYAVELAQELAEKPRNSLVTLKDHLVAPLRDQ LPRVIEQELMMHEKTFHHEEVKSRIKGLYGN*" gene 1792012..1792761 /gene="pksI" /locus_tag="BSU_17170" /old_locus_tag="BSU17170" CDS 1792806..1807937 /gene="pksJ" /locus_tag="BSU_17180" /old_locus_tag="BSU17180" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16707694, 17234808, 17827323, 26284661, 26268540; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyketide synthase of type I involved in nonribosomal synthesis of bacillaene" /protein_id="NP_389598.3" /db_xref="EnsemblGenomes-Gn:BSU17180" /db_xref="EnsemblGenomes-Tr:CAB13589" /db_xref="GOA:P40806" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR013968" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR018201" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020807" /db_xref="InterPro:IPR020841" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR032821" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036736" /db_xref="PDB:4J1Q" /db_xref="PDB:4J1S" /db_xref="PDB:4NA1" /db_xref="PDB:4NA2" /db_xref="PDB:4NA3" /db_xref="PDB:5KTK" /db_xref="SubtiList:BG10929" /db_xref="UniProtKB/Swiss-Prot:P40806" /translation="MRNNDNIRILTNPSVSHGEPLHISEKQPATIPEVLYRTATELGD TKGIIYLQPDGTEVYQSYRRLWDDGLRIAKGLRQSGLKAKQSVILQLGDNSQLLPAFW GCVLTGVVPAPLAVPPTYAESSSGTQKLKDAWTLLDKPAVITDRGMHQEMLDWAKEQG LEGFRAIIVEDLLSAEADTDWHQSSPEDLALLLLTSGSTGTPKAVMLNHRNIMSMVKG IIQMQGFTREDITFNWMPFDHVGGIGMLHLRDVYLGCQEINVSSETILMEPLKWLDWI DHYRASVTWAPNFAFGLVTDFAEEIKDKKWDLSSMRYMLNGGEAMVAKVGRRILELLE PHGLPADAIRPAWGMSETSSGVIFSHEFTRAGTSDDDHFVEIGSPIPGFSMRIVNDHN ELVEEGEIGRFQVSGLSVTSGYYQRPDLNESVFTEDGWFETGDLGFLRNGRLTITGRT KDAIIINGINYYSHAIESAVEELPEIETSYTAACAVRLGQNSTDQLAIFFVTSAKLND EQMSQLLRNIQSHVSQVIGVTPEYLLPVQKEEIPKTAIGKIQRTQLKTSFENGEFDHL LHKPNRMNDAVQDEGIQQADQVKRVREEIQKHLLTCLTEELHVSHDWVEPNANIQSLG VNSIKMMKLIRSIEKNYHIKLTAREIHQYPTIERLASYLSEHEDLSSLSADKKGTDTY KTEPERSQATFQPLSEVQKGLWTLQKMSPEKSAYHVPLCFKFSSGLHHETFQQAFGLV LNQHPILKHVIQEKDGVPFLKNEPALSIEIKTENISSLKESDIPAFLRKKVKEPYVKE NSPLVRVMSFSRSEQEHFLLVVIHHLIFDGVSSVTFIRSLFDTYQLLLKGQQPEKAVS PAIYHDFAAWEKNMLAGKDGVKHRTYWQKQLSGTLPNLQLPNVSASSVDSQFREDTYT RRLSSGFMNQVRTFAKEHSVNVTTVFLSCYMMLLGRYTGQKEQIVGMPAMVRPEERFD DAIGHFLNMLPIRSELNPADTFSSFISKLQLTILDGLDHAAYPFPKMVRDLNIPRSQA GSPVFQTAFFYQNFLQSGSYQSLLSRYADFFSVDFVEYIHQEGEYELVFELWETEEKM ELNIKYNTGLFDAASISAMFDHFVYVTEQAMLNPSQPLKEYSLLPEAEKQMILKTWNA TGKTYPYITFHELFEQQAKKTPDRAAVSYEGQTLTYRELDEKSTQLAIYLQAHGVGPD RLAGIYVDRSLDMLVGLLAILKAGGAYVPLDPSYPAERLEYMLEDSEVFITLTTSELV NTLSWNGVTTALLDQDWDEIAQTASDRKVLTRTVTPENLAYVIYTSGSTGKPKGVMIP HKALTNFLVSMGETPGLTAEDKMLAVTTYCFDIAALELFLPLIKGAHCYICQTEHTKD VEKLKRDIRAIKPTVMQATPATWKMLFYSGWENEESVKILCGGEALPETLKRYFLDTG SEAWNMFGPTETTIWSAVQRINVECSHATIGRPIANTQIYITDSQLAPVPAGVPGELC IAGDGVAKGYYKKEELTDSRFIDNPFEPGSKLYRTGDMARWLTGGRIEYIGRIDNQVK IRGFRIELGDIESRLSEHPGILECVVVADMDNLAAYYTAKHANASLTARELRHFVKNA LPAYMVPSYFIQLDHMPLTPNGKIDRNSLKNIDLSGEQLKQRQTSPKNIQDTVFTIWQ EVLKTSDIEWDDGFFDVGGDSLLAVTVADRIKHELSCEFSVTDLFEYSTIKNISQYIT EQRMGDASDHIPTDPAAHIEDQSTEMSDLPDYYDDSVAIIGISCEFPGAKNHDEFWEN LRDGKESIAFFNKEELQRFGISKEIAENADYVPAKASIDGKDRFDPSFFQISPKDAEF MDPQLRMLLTHSWKAIEDAGYAARQIPQTSVFMSASNNSYRALLPSDTTESLETPDGY VSWVLAQSGTIPTMISHKLGLRGPSYFVHANCSSSLIGLHSAYKSLLSGESDYALVGG ATLHTESNIGYVHQPGLNFSSDGHIKAFDASADGMIGGEGVAVVLLKKAADAVKDGDH IYALLRGIGVNNDGADKVGFYAPSVKGQADVVQQVMNQTKVQPESICYVEAHGTGTKL GDPIELAALTNVYRQYTNKTQFCGIGSVKTNIGHLDTAAGLAGCIKVVMSLYHQELAP SVNYKEPNPNTDLASSPFYVVDQKKTLSREIKTHRAALSSFGLGGTNTHAIFEQFKRD SDKGKIDGTCIVPISAKNKERLQEYAEDILAYLERRGFENSQLPDFAYTLQVGREAME HRVVFIADHVNELKQRLTDFINGNTAIEGCFQGSKHNAREVSWLTEDEDSAELIRKWM AKGKVNKLAEMWSKGAHIDWMQLYKGERPNRMSLPTYPFAKERYWPSQDDRKPVAQIS GNQTGIGSIHPLLHQNTSDFSEQKFSSVFTGDEFFLRDHVVRGKPVLPGVAYLEMAYA AINQAAGSEIGQDVRIRLNHTVWVQPVVVDRHSAQVDISLFPEEDGKITFDIYSTQED GDDPVIHSQGSAELASAAETPVADLTEMSRRCGKGKMSPDQFYEEGRSRGMFHGPAFQ GIKNVNIGNREVLAQLQLPEIVSGTNEQFVLHPSIMDSALQTATICIMQELTDQKLIL PFALEELEVIKGCSSSMWAYARLSDSDHSGGVVQKADIDVIDESGTVCVRIKGFSTRV LEGEVHTSKPSTRHERLMLEPVWEKQNEEREDEDLSYTEHIIVLFETERSVTDSIASH MKDARVITLNEAVGHIAERYQCYMQNIFELLQSKVRKLSAGRIIIQAIVPLEKEKQLF AGVSGLFKTAEIEFSKLTAQVIEIEKPEEMIDLHLKLKDDSRRPFDKQIRYEAGYRFV KGWREMVLPSADTLHMPWRDEGVYLITGGAGSLGLLFAKEIANRTGRSTIVLTGRSVL SEDKENELEALRSIGAEVVYREADVSDQHAVRHLLEEIKERYGTLNGIIHGAGSSKDR FIIHKTNEEFQEVLQPKVSGLLHVDECSKDFPLDFFIFFSSVSGCLGNAGQADYAAAN SFMDAFAEYRRSLAASKKRFGSTISFNWPLWEEGGMQVGAEDEKRMLKTTGMVPMPTD SGLKAFYQGIVSDKPQVFVMEGQLQKMKQKLLSAGSKAKRNDQRKADQDQGQTRKLEA ALIQMVGAILKVNTDDIDVNTELSEYGFDSVTFTVFTNKINEKFQLELTPTIFFEYGS VQSLAEYVVAAYQGEWNQDATAKGKDERTNLVHSLSSLEASLSNMVSAILKVNSEDID VNTELSEYGFDSVTFTVFTNKINEEFQLELTPTIFFEYGSLHSLAEYLTVEHGDTLVQ EREKPEGQEELQTKSSEAPKITSRRKRRFTQPIIAKAERNKKQAADFEPVAIVGISGR FPGAMDIDEFWKNLEEGKDSITEVPKDRWDWREHYGNPDTDVNKTDIKWGGFIDGVAE FDPLFFGISPREADYVDPQQRLLMTYVWKALEDAGCSPQSLSGTGTGIFIGTGNTGYK DLFHRANLPIEGHAATGHMIPSVGPNRMSYFLNIHGPSEPVETACSSSLVAIHRAVTA MQNGDCEMAIAGGVNTILTEEAHISYSKAGMLSTDGRCKTFSADANGYVRGEGVGMVM LKKLEDAERDGNHIYGVIRGTAENHGGRANTLTSPNPKAQADLLVRAYRQADIDPSTV TYIEAHGTGTELGDPIEINGLKAAFKELSNMRGESQPDVPDHRCGIGSVKSNIGHLEL AAGISGLIKVLLQMKHKTLVKSLHCETLNPYLQLTDSPFYIVQEKQEWKSVTDRDGNE LPRRAGISSFGIGGVNAHIVIEEYMPKANSEHTATEQPNVIVLSAKNKSRLIDRASQL LEVIRNKKYTDQDLHRIAYTLQVGREEMDERLACVAGTMQELEEKLQAFVDGKEETDE FFRGQSHRNKETQTIFTADEDMALALDAWIRKRKYAKLADLWVKGVSIQWNTLYGETK PRLISLPSYPFAKDHYWVPAKEHSERDKKELVNAIEDRAACFLTKQWSLSPIGSAVPG TRTVAILCCQETADLAAEVSSYFPNHLLIDVSRIENDQSDIDWKEFDGLVDVIGCGWD DEGRLDWIEWVQRLVEFGHKEGLRLLCVTKGLESFQNTSVRMAGASRAGLYRMLQCEY SHLISRHMDAEEVTDHRRLAKLIADEFYSDSYDAEVCYRDGLRYQAFLKAHPETGKAT EQSAVFPKDHVLLITGGTRGIGLLCARHFAECYGVKKLVLTGREQLPPREEWARFKTS NTSLAEKIQAVRELEAKGVQVEMLSLTLSDDAQVEQTLQHIKRTLGPIGGVIHCAGLT DMDTLAFIRKTSDDIQRVLEPKVSGLTTLYRHVCNEPLQFFVLFSSVSAIIPELSAGQ ADYAMANSYMDYFAEAHQKHAPIISVQWPNWKETGMGEVTNQAYRDSGLLSITNSEGL RFLDQIVSKKFGPVVLPAMANQTNWEPELLMKRRKPHEGGLQEAALQSPPARDIEEAD EVSKCDGLLSETQSWLIDLFTEELRIDREDFEIDGLFQDYGVDSIILAQVLQRINRKL EAALDPSILYEYPTIQRFADWLIGSYSERLSALFGGRISDASAPLENKIEAEASVPGK DRALTPQIQAPAILSPDSHAEGIAVVGLSCRFPGAETLESYWSLLSEGRSSIGPIPAE RWGCKTPYYAGVIDGVSYFDPDFFLLHEEDVRAMDPQALLVLEECLKLLYHAGYTPEE IKGKPVGVYIGGRSQHKPDEDSLDHAKNPIVTVGQNYLAANLSQFFDVRGPSVVVDTA CSSALVGMNMAIQALRGGDIQSAIVGGVSLLSSDASHRLFDRRGILSKHSSFHVFDER ADGVVLGEGVGMVMLKTVKQALEDGDIIYAVVKAASVNNDGRTAGPATPNLEAQKEVM KDALFKSGKKPEDISYLEANGSGSIVTDLLELKAIQSVYRSGHSSPLSLGSIKPNIGH PLCAEGIASFIKVVLMLKERRFVPFLSGEKEMAHFDQQKANITFSRALEKWTDSQPTA AINCFADGGTNAHVIVEAWEKDEKHAIKRSPISPPQLKKRMLSPGEPKLEAETSKMTA ANIWDTYEVEV*" gene 1792806..1807937 /gene="pksJ" /locus_tag="BSU_17180" /old_locus_tag="BSU17180" promotor_-10 complement(1797651..1797670) /Source="Nicolas_upshift_promotors" /id="U1371" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1370 /SigmaFactorBS="ttcttaaggctgtttctatctatctttccgttcgGAGTTAAC GGcatatgatcaagcTGAATAAAATAAGAAGGCACcatataggcaggcaaagcgtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1797667) /Source="Nicolas_upshifts" /id="U1371" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1370 /SigmaFactorBS="ttcttaaggctgtttctatctatctttccgttcgGAGTTAAC GGcatatgatcaagcTGAATAAAATAAGAAGGCACcatataggcaggcaaagcgtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1797684..1797693) /Source="Nicolas_upshift_promotors" /id="U1371" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1370 /SigmaFactorBS="ttcttaaggctgtttctatctatctttccgttcgGAGTTAAC GGcatatgatcaagcTGAATAAAATAAGAAGGCACcatataggcaggcaaagcgtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1807921..1821537 /gene="pksL" /locus_tag="BSU_17190" /old_locus_tag="BSU17190" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16707694, 16757561, 17234808, 22720735, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyketide synthase of type I (bacillaene synthesis)" /protein_id="NP_389600.3" /db_xref="EnsemblGenomes-Gn:BSU17190" /db_xref="EnsemblGenomes-Tr:CAB13602" /db_xref="GOA:Q05470" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR011254" /db_xref="InterPro:IPR013968" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR018201" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020807" /db_xref="InterPro:IPR020841" /db_xref="InterPro:IPR032821" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036736" /db_xref="PDB:5E1V" /db_xref="PDB:5E5N" /db_xref="PDB:5E6K" /db_xref="PDB:5ENY" /db_xref="PDB:5ERF" /db_xref="SubtiList:BG10698" /db_xref="UniProtKB/Swiss-Prot:Q05470" /translation="MRWRSNVKKITKQLTLSLKNPFIYHHVVYGQNVLPGLAYIDIIY QIFREHGFSCSELQLRNLSIYQPLTAEQDAVIVLNIQCAEKKEGQWQITAKGIEKRDG KEASEEKLYMKADMHADSPAIFEETLDLSQIKASAQNVVQLDDVYEQCRRQELVHSEY MKAKGCIYEEEDGVLLELSLGSEAMLHAEGFMFHPTLIDGSGVGANHLLTSLLKGEQR LYLPLFYESFSASALLQTDCMTRIKRSSVRREKELIYVTLEFFNASGEKVAELKNFTS KLVREAELISGKHQDAQETQMTRADTAERDKPADMVSSPVNSYSEAEQFVSQLIAEKI NKPVEQVEKQVGYYQMGLNSSGLLEVVETISDKIGESLSPTLLFEHTTIAELSAFLAE EYAEHFSAAGSLGQNERARVSDSINDHKTVEGSRPAPIEAAGDIAIIGLAGRYPKAAN IHEFWNNLKEGKDCVSEIPESRWDWQRLEGITSPSGKDISKWGGFIDDPDCFDPQFFR ITPREAETMDPQERLFLETCWETIEDAGYTPKTLAKPKGRNKRQHVGVFAGVMHKDYT LVGAEEASAENVFPLSLNYAQIANRVSYFCNFHGPSMAVDTVCSSSLTAVHLALESIR HGECDVALAGGVNLSLHPNKYMTYGVWDMFSTDGHCRTFGKDGDGYVPAEGIGAVLLK PLRQAEEDGDRIYAVIKGSAVNHVGTVSGISVPSPVSQADLIETCLEKTGIDPRTISY VEAHGTGTSLGDPIEIQGLVKAFRQYTQDRQFCSIGSVKSNIGHAESAAGISGLSKVA LQLHHQKLVPSLHSEELNPYVDFEKSPFYVQHETETWKQPVIKENGEDVPYPRRAGIS SFGATGSNAHIILEEHIPQAAEQDVSLSSDSDISAVIPLSARNQERLRVYAKRLLDFL HDGIQIRDLAYTLQVGREPMEERVSFLASGIQELSDQLKAFIEGRKAIQHCWKGRVSR GSEPSRPAESVHKLLEQRKLDQIAEQWANGSGVDWKLLYEGSKPKRISLPTYPFERVR YWVPKAEKKTDRSKQERHILHPLLHQNVSDISGVRFRSAFTGREFFLKDHVIKGEHVL PGAALLEMVRAAVERAAADQFPTGFRLRNIVWVRPFAVTEQQKDIDVRLYPEENGEIT FEICRDPESAEESPIVYGQGSAVLCEAGENPVINIEELKASYNGRTLSPFDCYEAYTE MGIHYGDSHRAIDSLYAGENGVLVKLTMPPVISDTEDHYILHPSMIDSAFQASIGLRL GGATSLEDRKAMLPFAIQDVRIFKGCEASMWARITYSEGSTAGDRMQKLDIDLCNEEG QVCVRLTSYSARVLETDQEGPSEANDTLLFEHIWEERAAERQELIEYDTYKVVVCDVG EQMESLQNHLDCTVLQHDTETIDERFEGYAIQLFEEIKQLMHSKTGGHTFIQVAVPAL DEPQLLSGLTGLLKTAELENPKLTGQLIEIETGMSAGELFEILEENRRYPRDTHIRHW QGKRFVSKWKEVSGEHLSADMPWKDKGVYLITGGAGGLGFIFATEIANQTNDAVVILT GRSPLDERKKKKLKALQKLGIQAIYRQADLADKQTVDALLKETQNVYGDLDGIIHSAG LIKDNFIMKKKKEEVQTVLAPKVAGLIHLDEATKDIPLDFFILFSSGAGAVGSAGQAD YAMANAFMNAFSEYRNGQAELHKRYGKTLSVCWPLWKDGGMQIDAETARMLKRETGMV AMETDRGIQALYHGWTSGKPQVLVASGVTDRIRAFLHETGHGKGQSHNIKKSSLNQEA EKADMIGEIDEEILREKAENYFKQVLSSVIKLPAGQIDAEAPLEDYGIDSIMIMHVTG QLEKVFGSLSKTLFFEYQDIRSLTRYFIDSRREKLLDILGFETGKPSVERKSEPEKQE IPVIPRKSGFLPLQDKEQKQVREKETEEIAIIGISGRYPQADNIDELWEKLRDGRDCI TEIPADRWDHSLYYDEDKDKPGKTYSKWGGFMKDVDKFDPQFFHISPREAKLMDPQER LFLQCVYETMEDAGYTREHLGRKRDAELGGSVGVYVGVMYEEYQLYGAQEQVRGRSLA LTGNPSSIANRVSYYFDFHGPSIALDTMCSSSLTAIHLACQSLQRGECEAAFAGGVNV SIHPNKYLMLGQNKFMSSKGRCESFGQGGDGYVPGEGVGAVLLKPLSKAVEDGDHIYG IIKGTAINHGGKTNGYSVPNPNAQADVIKKAFVEAKVDPRTVSYIEAHGTGTSLGDPI EITGLSKVFTQETDDKQFCAIGSAKSNIGHCESAAGIAGVTKVLLQMKYRQLAPSLHS NVLNPNIDFLNSPFKVQQELEEWKRPIISVNGKDIELPRIAGVSSFGAGGVNAHILIE EYAPEPVEERLPARKQPAVIVLSAKNEERLQKRAERLLHAIREQTYVEADLHRIAYTL QVGREAMKERLAFVAETMQELEEKLYECISGTENREYVYRGQVKSNKEAIAAFAADED MSKTIEAWLQKGKYAKVLDLWVRGLRIDWSTLYQDQKPRRISLPAYPFARDRYWIDVN AKAEEKRTEEPFAPVQPVIPKPSVDREASGKPANITLQPLMTNQDRLERVPSDTETET ITAEALCDELTAGLAEVLYMDQNEIDPDEAFIDIGMDSITGLEWIKAINKQYGTSLNV TKVYDYPTTRDFAVYLAHELSTQAGEKKQTETYTPIRQKTVVPAAKPANISLQPLEHH QPVQEEAEETIQYAAAEISASRQYTVAIETLHENLRESIADVLYMEPYEVDIDEAFID IGMDSITGLEWIKAVNKQYGTSFTVTRVYDYPTIRDFAEMLKSELGTHLDRKIEHTDS FEAAQQKPAASSHPKPAERPLQPVQHPIKKEHEKKTVPVLQDRPEDAIAIVGMSGRYP GARNVREYWDNLVHARNAIRDIPTSRWDVDKYYDPVLNKKGKVYCKSMGMLDDIEHFD PLFFNIPPSEAELMDPQHRIFLQEGYKAFEDAGYNARTLNEKKCGVYLGIMSNEYGVM LNRQSRANATGNSFAIAAARIPYFLNLKGPAIPIDTACSSSLVGTHLARQALINKEID MALVGGVSLYLTPESYMSMCEAGMLSPDGQCKAFDNGANGFVPGEGAGALVLKRLKDA EADRDHIYGIIIGSGINQDGKTNGITAPSAKSQMDLERDIYETYGIHPESISYVEMHG TGTKQGDPIELEALSTVFQEKTDKKQFCAIGSVKSNIGHTSAAAGVAGVQKVLLCMNH KTLVPTLNFTTPNEHFEFEHSPLYVNTELKPWETADGKPRRACVSSFGYSGTNAHIVI EEYQPEKRNDRLTKQHRSALFVLSAKKEKQLKAYAEAMKDFVTSNEDIDLEDMAYTLQ TGREAMDYRMAFLADSREMLIKALDDYLAEMPNGSIFAAHVKTKKSEIKLFETDHDAK ALLQTWIEKKRLEKVAELWVKGLQIDWNKLYGEYTPRRISLPAYPFAEEYYWLPTQEG EPETIATAMPQFELMPKRCFLRKQWQPCPIEPAEMTNQTVAILANEETMALAEELSAY FSTYRIFDSQELDRVSAADYEHVAGAIDLIGCGTSHEHSMGWINWLQKLIEQGRASKH HLTVLGVTKGLEAYANEGVLLSGASRAGLYRMLQSEYSHLTSRHADMECEASHEELAR LIAVEYYAKSTESEVCYRNGQRYRAYLTEQPAEAALSHKQVSFSTDKVLLITGGTRGL GLLCARHFVKTYGVKRLVLIGREELPPRDQWNSVKISSLAEKIKAVQELEDMGAQVQV LSLDLTDRVAVEQSLKTIHETMGAIGGVIHCAGMVNKQNPAFIRKSLEEIGQVLEPKV EGLQTLFDLLQDEPLAFFTLFSSVSAAIPALAAGQADYAMANAFMDYFAEAHQDKCPI VSIQWPNWKETGLGEVRSKALEQTGLISLTNDEGLQLLDQILSDRQYAVVLPAVPDTN VWKPDKLMQPSLPVEALSHPETKEQTSTRNLFPETVDWLVTLFSDELKIAAEDFETDE PFQEYGIDSIILAQLVQQMNQQLNGDIDPSILFEYPTIESFAHWLISKYDISAVLQPS VPEKQTPLKPQSAMKQKLVPEQRPQQISHEKTALLAEDIAIIGLSCRFPGAETLEEYW DLIRDGRSAIAPVPPERFGNSSSNYAGLIDEMNRFDHDFFMMSESDVRAMDPQALAVL EESLKLWYHAGYTEKEVKGMRAGVYIGGRSQHKPDPASLSKAKNPIVAGGQNYLAANI SQFFDLKGPSIVLDTACSSALVGLNMAIQALRSGDIEAAVVGGVSLLDADAHRMFHER GLLCDKPSFHIFDKRADGVILGEGVGMVLVKTVNQAVEDGDSIYAVIKAAAINNDGRT AGPSSPNLEAQKDVMLSALEKSGKKTEEISYLEANGSGSAVTDLLELKAIQSIYRSES KAPLGLGSVKPNIGHPLCAEGIASLIKVALMLKHRQLVPFLSGNENMPYFDIEKTDLY FSRSQAEWKETTPAAAINCFADGGTNAHLIIEGWRDSAERPIRRKPLPLPELNRQPVL IKPSAQNVQKKVHSDTGASKDMFWKTFK*" gene 1807921..1821537 /gene="pksL" /locus_tag="BSU_17190" /old_locus_tag="BSU17190" CDS 1821553..1834341 /gene="pksM" /locus_tag="BSU_17200" /old_locus_tag="BSU17200" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15480790, 16707694, 17234808, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15480790, 16707694, 17234808, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="trans AT polyketide synthase of type I involved in bacillaene synthesis" /protein_id="NP_389601.3" /db_xref="EnsemblGenomes-Gn:BSU17200" /db_xref="EnsemblGenomes-Tr:CAB13603" /db_xref="GOA:P40872" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR013217" /db_xref="InterPro:IPR013968" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR018201" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020807" /db_xref="InterPro:IPR020841" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR032821" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10931" /db_xref="UniProtKB/Swiss-Prot:P40872" /translation="MITEQLHISLNNPIMSNHKVYGQALLPGLAYIDLIYQVFQEHGY AYQELELKNLTIFYPLIADESYDIALTIHVSERKEGTWSIIIDGQKQHGESLSDKRQY VTADMHRKEQTAFAESIDLNQWKSTADRILNLDEIYEQCRSQELVHTGMMKAEGQIYE AKEGAVIDLAVGQEALRHSDAFLFHPTLIDGSGIGSSCLISDQTMYLPLYYESFSASE RLQKGCTARILSSSVRQKKELTYMTIEYFNSAGQKVAELKQFAGKSVRNMSAFHSAKE IQEERAAVSQNISRDYPAFEMYLRQLLAKQLERPAEQMDIHAGYYELGLDSSSLLTVV QEIGDKVGADLAPTLLFEFTTIAELAAHLADHYSIGEADDAVRQSPSPIDGVTSSPEI GEDIAIIGMAGRYPKAKNIQEFWEQLKAGTDCITEIPNSRWEWKESDGLDSPAGKPLS KWGGFIEEADCFDPQFFRISPREAEMMDPQERLFLETCWEAIEDAGYTPETIASPQGE NKRQHVGVFAGVMHKDYSLIGAEALSEHNPFPLSLNYAQIANRVSYYCNFHGPSMAVD TVCSSSLTAVHLAIESIRNGECEAALAGGVNLSLHPAKYISYGSVGMHSSDGYCHTFG KGGDGYVSGEGVGTVLLKPLRKAEQDGDRIYAVIKGSAINHVGKVSGITVPSPVAQAD VIEACLEKTGIDPRTISYVEAHGTGTSLGDPIEVQGLVKAFSRNTQDKQFCSIGSVKS NIGHAEAAAGISGLTKTVLQLHHKTLVPSLHSEELNPYLKLDQTPFFVQHETKEWEQP SFTENGVDVTYPRRAGLSSFGASGSNAHLILEEYIPAESHSETILTKNEEIVIPLSAR NKDRLQAYALKLLDFLSEDVNLLALAYTMQAGRVEMEERAAFIVKDIKDLTAKLRAFA NGEEEIEGCWTGRAKENQEAAGLASVNALNNNLIRDSEMMEMAKAWVQGKRVTWDDLY GDRKPLKISVPTYPFARERYWISVPEMKTSTVNHILHPLVHRNTSDFTEQRFSSVFTG TEFFLSDHVVQGQKILPGVAYLEMAREAAEKAAGDLDGEQRVVSLKDIVWVRPITIES EPKEIHIGLFPEDNGDISFDIYSSSEHKEEALTIHCQGRAVISDEAETSILNLSSIQT ECSLDTVTSEQCYAAFRKIGLDYGEGYQGIEKVYVGKDQLLAKISLPAFLKNDKQHFA LHPSLMDSAFHATVGFIVSSVNAAGQAQTLSLPFALQEVDIFSPCPEKIWSYIRYSSD SKAENKVRKYDIDLCDENGRVCVRMKGASMRALDGEQHSKPQLLTDSQLTGHTVMIPV WEPVSLEAEDNASFAGKRAVLCGAAEADRTFIKHHYPQISFVDIRPADDIEAIADKLQ AYGSIDHVLWIAPSHRGSIGSDGQEEAVLHLFKLVKACLQLGYGEKQLEWSLVTVQAQ PVTQHEAVQPAHASIHGLAGTMAKEYPHWKIRLLDLEKGCTWPVNHMFALPADRLGHA WAYRNQQWHQQQLIPYRSSLSGDTLYRKGGVYVVIGGAGYIGEAWSEYMIRRYQAQIV WIGRSQLNAAIQSKIDRLSALGPEPFYIAADAADKHSLQQAYEQVKKRHPHIHGIVHS AMVLFEQSLEKMKPEEFTAGLAAKIDVSIRMAQVFRQENVDFVLFFSSLVAHIKNVKQ SHYASGCTFADAFAHQLSQSWACPVKVMNWGYWGNSEAAEDEHYVQLMNQIGLGLIEP AEAMKALEALLSGPVSQTAFIHTTKPVAVEGVNQNEFITLYPEQPSADAESLMERLPT TGRFQRVTHEELDDLLYRLLLGQLQTAELFDGYTLSVERLQQYKTREFYGKWIRQSSE FLLQHGYLKKVGDSLVRKDQAEDIELLWLEWNAKKEKWLKDSETKAMVVLAEAMLQAL PDILTGKVPATDIMFPHSSMELVEGIYKHNQVADYFNKVLADTLLAYLDERLKHDPEA SIRIMEIGAGTGGTSAGIFEKLKPYQKHINEYCYTDLSKAFLLHAEKEYGAENPYLTY QLFDVEKPIDQQEFEAGGYDVVIAANVLHATKNIRQTLRHTKAVMKNNGMLLLNEMAG NSLFPHITFGLLEGWWLYEDPAVRIPGCPGLHPDSWKAALESEGFESVFFPAEAAHDL SHQIVAASSNGLVRRMMKNVILPEKVVSQASNQEPAYIHTIDSEEAGQSKHALLREKS TEYMKKLIGETLKIPAGKIESSEPLEKYGIDSIVVVQLTNTLRKEFDHVSSTLFFEYQ TIDALVEHFIKTKTEALMKLTGLDRQVQQHTPAESRTQSSQKPDQAAKRTRRFRKLGF SGEKETPTNTLASRDVAVIGISGRYPQAETAEDFWNNLKEGRNCIEEIPKDRWDWKAY YDKEKGKEGSIYTKWGGFIKDMDKFDPLFFQISPLEAERMDPQERLFLQTAYASIEDA GYTPDSLCSSRKIGVFAGVMNKNYPTGYGYWSIANRISYLLNFQGPSLAVDTACSSSL TAIHLALESIYSGSSDCAIAGGVNLVVDPVHYQNLSVMNMLSASDTCKSFGDDADGFV DGEGVGAIVLKPLQQAIADGDHIYGVIKASAINSGGKTNGYTVPNPHAQAQVIKEAIE RADIPARTISYLEAHGTGTALGDPIEIAGLTKAFEKDTQEKQFCAIGSSKSNIGHCES AAGIAGLTKILFQFKYGQIAPSLHAQRLNPNIEFSHTPFVVQQQLGEWKRPVIGGQEV PRRAGLSSFGAGGSNAHIILEEYIPRTGAQTPKDHPPALIVLSAKNMERLQEKAEQLL TAIKQKRYCETDLIRIAYTLQTGREAMEERLAFIAESLEDLERKLNDFIENKADSLYL DRIDDNKKALAVLSADEDTEKIIEAWMSKGKYTKLLDLWVKGLSFDWGMLYGTQTPVR ISLPAYPFAKERYWAPGAAKAPVSIEQDHDQQTEEPFKVMTFQEVWKEEPATLTSKRI KTLICFLTEREKQNAFASALKNVDQDTKVIFISQGEVYSKQSEYSYQIVRQEPVTFEK AFQSIKEELGEPDAILYMWPMEDKRCIKDHSCIVYLLQGMSAAKLHPSRLLLAGCFED SLDRSYLESWIGFERSLGLVLPHTKVTGIFQPAEQGSMDDWTRKVWAELQASTEQTVL YQNLKRYVNHIEQTTIQPDNSKLKSGGTYLITGGVGGLGYLFAKHLAKNYAANLILTG RSPFNDEKQKQIKELKDLGGEAMYAEADVSDPIAMGDCVKRGKDRFGAINGVIHAAGI ESDSAIFDKKIESFQRIIEPKINGTIALDEWLKNEDLDFMCYFSSSSAVLGDFGCCDY AIGNRFQMAYAQYRNELHNGKTFVINWPVWKDGGMKIGDEETTDMYLKSSGQRFLEAE EGIRMFEHILAQQDAQHLVIAGQPSRVSRFLGMTEPAIPEPATQAPLAQENKDEVKTL SIEKRLEHDLKEHIHTLLKISKDKLNLNKNWADFGFDSIYLAKFSNVLSKHFNIEVTP ALFFGYSTLQELISFFLTDHKELIEAFYRDDASEAQKPPEAYAVIPVALEPEASKKSI RQVHDEPIAIIGMSGRFPQADSVHELWDNLKNGKSCISDIPGERRDWGRANRDPEKAV PRWGAFLKDIDRFDPLFFQISPKEAESMDPRQRIFLEEAWHTFEDAGYMGDRIKGKSC GVYVGVEEGEYAHLTGDTDYINGTQNATLSARIAYALDLKGPNMALTAACSSGLVAIH QACSALRQGDCEMALAGGVSLNISHMSFEALTRAEMLSPNGQCKVFDQDANGLVPGEA VAAVLLKPLSKAIEDKDHIYGCIKASGVNYDGKTNGITAPNPFSQAELIENIYEKNEI NPLDIQYVMAHSTGSNLGDPLEVQALTSVFSKYTKQKQFCMISSIKPLIGHTFAASGT VALISMLMAMKNQIIPATHHCESENPYIPFKESPFVLCKENRSWIKKNQKPRMGTIST TGISGTNAHAVIEEYIPDDQPSTQRHQGSPQIFVISAQNDDRLQDAACRMIAYLEQNH NLSLPDVAYTLQVGRKAMEARLAIVANNQEQLVRKLKEYVEAMKNGGVSGQQRSLYTG YTEGILEEQDEAVLQALAKERNLENIAECWVKGYQIPWELLHDGDDVRMVSLPGYPFA RERYWISSGTQQSEAVKQHSQDMKTEIDEPNGKTHIQKIIVQFLARELGISEDRINFK RNFLDYGMDSILGRKLMRHIEKTTQLKMAGREILECQTVQALSDHLALKAEKQNHSAA AHHIKGTYTDEQIIGLMQEVALGKLDFKSVQNIIEGSKSYES*" gene 1821553..1834341 /gene="pksM" /locus_tag="BSU_17200" /old_locus_tag="BSU17200" CDS 1834409..1850875 /gene="pksN" /locus_tag="BSU_17210" /old_locus_tag="BSU17210" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16460000, 16707694, 17234808, 22720735, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="trans AT polyketide synthase of type I involved in bacillaene synthesis" /protein_id="NP_389602.3" /db_xref="EnsemblGenomes-Gn:BSU17210" /db_xref="EnsemblGenomes-Tr:CAB13604" /db_xref="GOA:O31782" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR013968" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR018201" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020807" /db_xref="InterPro:IPR020841" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR032821" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG12652" /db_xref="UniProtKB/Swiss-Prot:O31782" /translation="MKRQLKSPLSEGQKGLWMLQKMSPGMSAYNIPLCFRFSKPIHAE TFKKALLFVQRQYPVLASVIQEENGIPFQSVQLSKDLYFVEEDISAMKSADIMPFLKE KAKEPFQLEAGPLWRTHLFHRLEECIVLITIHHIIFDGVSMLTLISALFEAYQQLLNG IEPLQQPSTADYYDFVDWENRMLTGREGEEHLAYWKEQLSGSLPVLDLPADRPRSSAR KFKGQAYKSLLPHHLRNQIKSFARTNHVNESVVFLSIYKVLLHHYTKQKDIIVGVPTM GRQEDRFETLIGYFINMMAVRSKNIGSQPLTAFIRELQLTVAVGLDHAAFPFPALVRE LNVDRSAADSPVFQTAFLYQNFFQATGLQKVLEPYQTLGIEYIEDIRQEGEFELALEI YEQENETVLHLLYNPDLYELSSIESMMENYMKLAQHMMEDPSLPLEAYSLQLNQEQTS LLEQWNATGTNIANDKCIHEVFEEKAKQTPDAVAVMFEDRSLTYKEVDEKSTSVAVYL QHQGVRPEQPVGICAERSFDMIIGILGILKAGGAYVPLDPSFPQERLKYMLKDSQASI VLTQPNVHDRISGLTGSHVKAINIELACRNGYTDQQSSGLKREVKPEHLAYIIYTSGS TGEPKGVMVEHRSIMNTLNFLESHYPVTAEDAYLLKTNYVFDVSISELFGWFIGDGRL VILPPNGEKSPQLCMDYIETYKVTHINFVPAMLHVFLEMAKDNKRFTEDGPLKYMMVA GEAFPKVLVKKAVSLFTNCRVENIYGPTEASIYAAYFGCGKGDIASHHTPIGKPVSNT KIYIVDQHLKPVPIGKPGELCIAGAGLARGYFKKPGLTAEKFIDNPFESGTKLYKSGD SARWLPDGNIEYLGRIDSQVKIRGFRVELGAIETKLGEFPGILDQAVVVKQLEGHQQL AAYYTEESGHASANPKDLRLHLKSSLPEYMIPSHFIRLDELPLSPSGKVNRKELEKRE IVFNRRKPNHLQLTEIEDQVLRIWEETLKVSGFGPEDGFFDAGGDSLLAVAVAERIKK EFDCEFHVTELFEYSTIRAISEYILEMKNSDLAGTQNEDDHDDKKDGKYPKQKIPPYF DDSVAIVGISCQFPGAKNHHDFWNHIKEGKESIRFFSEEELRANGVPEELIQHPDYVP VQSVIEGKDLFDPGFFQISPKDAEYMDPQLRLLLLHSWKAIEDAGYVAKEIPATSVYM SASSNSYRTLLPKETTEGHESPDGYVSWVLAQSGTIPTMISHKLGLKGPSYFVHSNCS SSLVGLYQAYKSLTSGESQYALVGGATLHAQSAIGYVHQNGLNFSSDGHVKAFDASAD GMAGGEGVAVILLKKAVDAVKDGDHIYAIMRGIGINNDGAEKAGFYAPSVKGQTEVIQ HVLDTTKIHPETVSYIEAHGTGTKLGDPIEMSALNKVYKQYTDKTQFCGIGSVKTNIG HLDTAAGLAGCIKVAMSLYHNELAPTINCTEPNPDIKFESSPFYVVRERKSLEKHAGV HRAALSSFGLGGTNAHAIFEQYENISDAGAENEGNQPYIIPISAKNSERLQVYAKEML SYISQDEQRHFSLRDIAYTFQVGREAMDNRIVFIVNDLEEWKHQLEAFVTGKPLAEGC IQGEKTRMTSAEQLLGNAEADDMASSRISKEELRKLAEMWANGFHVEWRRLYPNIKPR RISLPTYPFAEERYWPESSTGAITTIEPSRLHPLVHHNTSVLSEQRFSSIFTGQEYFI AEHIIKGMAILPAAVTLEMARAAIEQGIGGLEDHETGIRLKNVVWVRPVVAGSEPVQV NIGLYDEDGGHIAYRMYGDPESADAEPVVYNQGKAELIQLKREKALDLSKIKKQCDQS KMDAASFYEGMIGADYGPGYKSVEAVYKGDGQLLAKLSLPESVAHTLGDYVLHPSVMD GALQAAEYLQNVVRAELSDTEDFKAALPFALEELEVFRQCVSDMWVYVQFNSKNKPGD LIQKVDIHLCDEHGMICVRLKGFSTRVMEADIQTEPSKINAETLLLQPVWQEQKAANS LAAKKYAEHLVFLCEYDHETRKQIEAAIEDVHVYSLEARPSSVDGRFHSYTEQVFKKV QEIIRTKPKDGILVQIVTSAEGEQQLFSGLTGLLKTACQENAKLTGQMIEVSSEESGE SIAGKLLENQMSSDSYVKYQNGTRYIADWREIKQAKGDGSKPWKDNGVYLISGGAGGL GHIFAKEIAEQTKNATVILAGRSPLSESKSKKLKELHSKGADITYRQTDVTNKIEVYQ LIDDIQKRYGRLNGILHSAGIIKDSYLVNKQAKDLHDVLAPKVKGLVYLDEASKDLPL DFFILFSSLSGSLGSIGQSDYAAANVFMDMYAGYRNRLADLSQRHGQTLSVNWPLWRD GGMQVDQETEKRLVQLAGIVPMRAEKGIQALYQALHSEANQVMVIEGDVQKIKQNMLA KNASAPMEKKEAEHMTEQINSIDADSLLDKVKAMLKREIAKLLKVKLETIDDHAEMTV YGFDSISMTEFTNHINRAYQLELTPTVFFDHPTIHAFGKHLSEEYQSVFAKTFAVRAV SAQLQPAAKQEQAVRAKAKRRRKQQVMLPNAIQSDAGPEPIAIVGISGIFPMAKDVEA YWNILKEGKDCMTEIPKDRWDWREYEGDPAKEVNKTNVKWGGFIDGIADFDPLFFGIS PREAEQMEPQQRLLLTYAWKAIEDAGYSAKRLSGTKTGVFIGTGNTGYSSLLSKANSA IEGSAAANTSPSVGPNRVSYFLNLHGPSEPVDTACSSSLVAIHHAISSIEEGTCDMAL AGGVNTIILPEVYISFDKAGALSKEGKCKTFSNQADGFAHGEGAGILFLKKLKAAEEA GDHIYGVIKGSAINHGGRAASLTTPNPKAQADVIQSAYQKAGIDPKTVTYIEAHGTGT ELGDPVEINGLKSAFKALGVNEGDTSANPYCGLGSVKTNIGHLSLAAGAAGVIKILLQ LKHKTLVKSLHCENVNPYIQLKNSPFYIVRETEEWKALKNEQGEELPRRAGVSSFGIG GVNAHVIIEEYIPEASDENIPSIAPEHPGIFVLSAKNEARLKEHAQQLADALDKQTYS DVNLARIAYTLQAGRDAMEERLGIISGSIEDLQKKLKDFAAEKSGVEDVFKGRIDKGT LQMLTEDEEIQEAVEKWMERGKYAKLLELWVKGLDVDWTKLYGENLPKRISLPTYPFA KDRYWISDHIEKSGSIDANQAASRLGGAVLHPLMHQNTSNLSEQRFSSIYTGEEFFLA DHVVKGQRILPGVAHLELARAAVEQAAEVQGVPRIMKLKNAVWVRPIVVEDQPQQVHI RLLPGENGEISYEIYGHSDVTGEQSIVYSQGSAVLNPAENLPAVDLQSLREQCQESHF SVNEVYDTYRMIGFEYGPAYRGVKKIYTAEQFVLAKLSLHPSAADTLSQYKMHPGLMD SALQASSILTGAGDNQLTLPFAVQELEVFGACSSEMWVYARYSQGSKATDKVQKRDMD ILDESGNVCVRMKGLSFRAAEGGSGSAESDQTLATLMFEEKWVPKDFKKESPEPHYER HIVMLCDMNGLSKDRIESRMTGAECIVLESFREGLAERFQDYAEQALETVQGLLKSRP QGNVLIQLLTSAQRKQYSFSGLSALLKTAGLENKKLIGQTIEIDSHENVESVIEKLKE NKRHTEDQHIKYEKGKRYINDLDEMQIDDREISMPWRDKGVYLITGGAGGLGFIFAKE IARQAEQPVLILTGRSALNADQQAELNELQQLGARAEYRQVDVTQTEAASELITSITS DYEDLNGVIHSAGLIKDNYLMSKTNEELTQVLAPKVKGLVNVDEATEHLALDFFILFS SISSVAGSAGQADYAMANAFMDSYAAYRNALVTAMYRHGQTLSINWPLWKEGGMRANK EIENMTLKNTGVTPMRTETGIQALYKGLAFGKDQVIVMEGFKDMMREKLTQKPSSDDV PMKTVQVRVTSEARMDQGNMFDHIQEVLKQTISQLLKIKPEEIDPDMEFNQYGFDSIT LTEFANTLNEKCKLDLTPTVFFEHATVYAFAGYLSEEYPNAFTAQTPAKAEVLMQPVE QNIKNMTFSTENRFVKPSVTPMQKEADHKPEPIAIVGMSGVFPKAKDVEEYWKNLSSG ADCITEVPKDRWDWQEYYGDPLKEANKTNVKWGGFIDEVADFDPLFFGISPLEAEQME PQQRLLMTYAWKAVEEAGHSARSLAGTKTGIFIGTGNTGYSSLLSNVDIEGSAAANMS PSAGPNRVSYFLNIHGPSEPIDTACSSSLVAIHHAVCAIENGNCEMAIAGGVNTVVTP QGHIAYDKAGALSKEGRCKTFSDKADGFAVSEGAGILFLKKLTAAERDGDHIYGVIKG SAVNHGGRANSLTTPNPKAQADVVKTAYEKAGIDPRTVTYIEAHGTGTELGDPVEING LKAAFKELYEKTGDPAVHGSHCGLGSAKTNIGHLSLAAGVAGVIKVLLQLKHKTLVKS LYSETVNPYIRLDDSPFYIVQESREWQALRDEAGRELPRRAGISSFGIGGVNAHVVIE EYIPKETTHPATAPAVTAQHPGIFILSAKDEDRLKDQARQLADFISKRSITARDLTDI AYTLQEGRDAMEERLGIIAVSTGDLLEKLNLFIEGGTNAKYMYRGRAEKGIAQTLRSD DEVQKTLNNSWEPHIYERLLDLWVKGMEIGWSKLYDGKQPKRISLPTYPFAKERYWIT DTKEEAAAHQTALKTVESAALHPLIHVNTSDLSEQRFSSAFTGAEFFFADHKVKGKPV MPGVAYLEMVHAAVTRAVRRTEDQQSVIHIKNVVWVQPIVADGQPVQVDISLNPQQDG EIAFNVYTEAAHNDRKIHCQGSASIRGAGDIPVQDISALQDQCSLSTLSHDQCYELFK AIGIDYGPGFQGIDRLYIGRNQALAELSLPAGVTHTLNEFVLHPSMADSALQASIGLK LNSGDEQLSLPFALQELEIFSPCTNKMWVSVTSRPNEDKIQRLDIDLCDEQGRVCVRI KGITSRLLEEGIQPPDGPTSLGNSKATLNGALLMAPIWDRVQLEKRSISPADERVVIL GGDDNSRKAVQREFPFAKELYIEPNASIHRITGQLEALGSFDHIVWMSPSRVTECEVG DEMIEAQDQGVIQMYRLIKAMLSLGYGQKEISWTIVTVNTQYVDQHDIVDPVDAGVHG LIGSMSKEYPNWQTKLIDVKKYEDLPLSQLLSLPADQEGNTWAYRNKIWHKLRLIPVH NNQPVHTKYKHGGVYVVIGGAGGIGEAWSEYMIRTYQAQIVWIGRRKKDAAIQSKLDR FARLGRAPYYIQADAANREELERAYETMKQTHREINGIIHSAIVLQDRSLMNMSEECF RNVLAAKVDVSVRMAQVFRHEPLDFVLFFSSVQSFARASGQSNYAAGCSFKDAFAQRL SQVWPCTVAVMNWSYWGSIGVVSSPDYQKRMAQAGIGSIEAPEAMEALELLLGGPLKQ LVMMKMANETNDEAEQTEETIEVYPETHGSAIQKLRSYHPGDNTKIQQLL*" gene 1834409..1850875 /gene="pksN" /locus_tag="BSU_17210" /old_locus_tag="BSU17210" CDS 1850890..1858521 /gene="pksR" /locus_tag="BSU_17220" /old_locus_tag="BSU17220" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10960106, 15480790, 16707694, 17234808, 22720735, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="trans AT polyketide synthase involved in nonribosomal synthesis of bacillaene" /protein_id="NP_389604.2" /db_xref="EnsemblGenomes-Gn:BSU17220" /db_xref="EnsemblGenomes-Tr:CAB13606" /db_xref="GOA:O31784" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR013217" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR018201" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020807" /db_xref="InterPro:IPR020841" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR032821" /db_xref="InterPro:IPR036736" /db_xref="PDB:4U3V" /db_xref="SubtiList:BG12654" /db_xref="UniProtKB/Swiss-Prot:O31784" /translation="MLNTEDILCKMLFAQLQSIGFFTESKSQPVLENFYGRWFEESQS ILERHQFLKRTENGHVPTRSIGTMSELWKEWNEQKFDLLQDNNMKAMVTLVETALKAL PEILTGKASATDILFPNSSMDLVEGVYKNNQVADYFNDVLADTLTAYLQERLKQEPEA KIRILEIGAGTGGTSAAVFQKLKAWQTHIKEYCYTDLSKAFLMHAENKYGPDNPYLTY KRFNVEEPASEQHIDAGGYDAVIAANVLHATKNIRQTLRNAKAVLKKNGLLLLNEISN HNIYSHLTFGLLEGWWLYEDPDLRIPGCPGLYPDTWKMVLESEGFRYVSFMAEQSHQL GQQIIAAESNGVVRQKKRTEAEEDPSHIQMNAEIDHSQESDSLIEQTAQFVKHTLAKS IKLSPERIHEDTTFEKYGIDSILQVNFIRELEKVTGELPKTILFEHNNTKELVEYLVK GHENKLRTALLKEKTKPAKNEAPLQTERTDPNKPFTFHTRRFVTEQEVTETQLANTEP LKIEKTSNLQGTHFNDSSTEDIAIIGVSGRYPMSNSLEELWGHLIAGDNCITEAPESR WRTSLLKTLSKDPKKPANKKRYGGFLQDIEAFDHQLFEVEQNRVMEMTPELRLCLETV WETFEDGGYTRTRLDKLRDDDGVGVFIGNMYNQYFWNIPSLEQAVLSSNGGDWHIANR VSHFFNLTGPSIAVSSACSSSLNAIHLACESLKLKNCSMAIAGGVNLTLDLSKYDSLE RANLLGSGNQSKSFGTGNGLIPGEGVGAVLLKPLSKAMEDQDHIYAVIKSSFANHSGG RQMYTAPDPKQQAKLIVKSIQQSGIDPETIGYIESAANGSALGDPIEVIALTNAFQQY TNKKQFCAIGSVKSNLGHLEAASGISQLTKVLLQMKKGTLVPTINAMPVNPNIKLEHT AFYLQEQTEPWHRLNDPETGKQLPRRSMINSFGAGGAYANLIIEEYMETAPEKEHIAP RQQEFTAVFSAKTKWSLLSYLENMQLFLEKEASLDIEPVVQALHRRNHNLEHRTAFTV ASTQELIEKLKVFRTSRESSLQQGIYTSFDLQPCAESASRDREINAAEQWAQGALIAF KEADIGNRTGWVHLPHYAFDHNTSFHFDVSSINEKSSDVEDNINQPVIQDQFTYDEPY VQGHVFNNERVLVGATYGSLAIEAFFNLFPEENSGRISKLSYISPIVIKQGETIELQA KPLQKDQVIELQIMYREPSSGLWKPAAIGQCGIGSFEPKKVNIENVKHSLTKLHHIDQ MYKTGNGPEWGELFKTITHLYRDHKSILAKIRLPQSGLANGHHYTVSPLMTNSAYLAI LSFLEQFDMTGGFLPFGINDIQFTKQTIKGDCWLLITLVKNTGDMLLFDVDVINESSE TVLHYSGYSLKQLRISNQRGNQNKAIKASNLKARIRSYVTDKLAVNMADPSKLSIAKA HIMDFGIDSSQLVALTREMEAETKIELNPTLFFEYPTIQELIDFFADKHEASFAQLFG EAHQQEERPAQIENQMKQIPAYETNTDKTIEHAADGIAIIGMSGQFPKANSVTEFWDN LVQGKNCVSEVPKERWDWRKYAAADKEGQSSLQWGGFIEGIGEFDPLFFGISPKEAAN MDPQEFLLLIHAWKAMEDAGLTGQVLSSRPTGVFVAAGNTDTAVVPSLIPNRISYALD VKGPSEYYEAACSSALVALHRAIQSIRNGECEQAIVGAVNLLLSPKGFIGFDSMGYLS EKGQAKSFQADANGFVRSEGAGVLIIKPLQKAIEDSDHIYSVIKGSGVSHGGRGMSLH APNPAGMKDAMLKAYQGAQIDPKTVTYIEAHGIASPLADAIEIEALKSGCSQLELELP QEVREEAPCYISSLKPSIGHGELVSGMAALMKVSMAMKHQTIPGISGFSSLNDQVSLK GTRFRVTAENQQWRDLSDDAGKKIPRRASINSYSFGGVNAHVILEEYIPLPKPPVSMS ENGAHIVVLSAKNQDRLKAIAQQQLDYVNKQQELSLQDYAYTLQTGREEMEDRLALVV RSKEELVIGLQACLAEKGDKLKSSVPVFSGNAENGSSDLEALLDGPLREMVIETLLSE NNLEKIAFCWTKGVQIPWEKLYQGKGARRIPLPTYPFEKRSCWNGFQAVENTPSVSQD ERINNSSDHHILANVLGMAPDELQFHKPLQQYGFDSISCIQLLQQLQSKVDPLIVLTE LQACHTVQDMMDLIAKKQEDTSLQNDQARTFPELIPLNDGKRGRPVFWFHGGVGGVEI YQQFAQKSQRPFYGIQARGFMTDSAPLHGIEQMASYYIEIIRSIQPEGPYDVGGYSLG GMIAYEVTRQLQSQGLAVKSMVMIDSPYRSETKENEASMKTSMLQTINTMLASIAKRE KFTDVLISREEVDISLEDEEFLSELIDLAKERGLNKPDKQIRAQAQQMMKTQRAYDLE SYTVKPLPDPETVKCYYFRNKSRSFFGDLDTYFTLSNEKEPFDQAAYWEEWERQIPHF HLVDVDSSNHFMILTEPKASTALLEFCEKLYSNRGVVNANFLKAFRKKHEAREEKETD ELVKR*" gene 1850890..1858521 /gene="pksR" /locus_tag="BSU_17220" /old_locus_tag="BSU17220" downshifts 1858510 /Source="Nicolas_upshifts" /id="D927" /incds=0 /nref=65 /ntot=216 /MaxReadThrough="0.92789" /MaxDrop="5.77685" /score="4.87908333" /energy="-14.6" /TU="NA" /idTUdmin="U1370" /TUdmin=1 /isTUend="TRUE" CDS complement(1858566..1859783) /gene="pksS" /locus_tag="BSU_17230" /old_locus_tag="BSU17230" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 17482575, 16707694, 17234808, 17886826, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 of bacillaene metabolism" /protein_id="NP_389605.2" /db_xref="EnsemblGenomes-Gn:BSU17230" /db_xref="EnsemblGenomes-Tr:CAB13607" /db_xref="GOA:O31785" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:4YZR" /db_xref="SubtiList:BG12655" /db_xref="UniProtKB/Swiss-Prot:O31785" /translation="MEKLMFHPHGKEFHHNPFSVLGRFREEEPIHRFELKRFGATYPA WLITRYDDCMAFLKDNRITRDVKNVMNQEQIKMLNVSEDIDFVSDHMLAKDTPDHTRL RSLVHQAFTPRTIENLRGSIEQIAEQLLDEMEKENKADIMKSFASPLPFIVISELMGI PKEDRSQFQIWTNAMVDTSEGNRELTNQALREFKDYIAKLIHDRRIKPKDDLISKLVH AEENGSKLSEKELYSMLFLLVVAGLETTVNLLGSGTLALLQHKKECEKLKQQPEMIAT AVEELLRYTSPVVMMANRWAIEDFTYKGHSIKRGDMIFIGIGSANRDPNFFENPEILN INRSPNRHISFGFGIHFCLGAPLARLEGHIAFKALLKRFPDIELAVAPDDIQWRKNVF LRGLESLPVSLSK*" gene complement(1858566..1859783) /gene="pksS" /locus_tag="BSU_17230" /old_locus_tag="BSU17230" downshifts complement(1858585) /Source="Nicolas_upshifts" /id="D928" /incds=0 /nref=123 /ntot=225 /MaxReadThrough="0.911470000000001" /MaxDrop="4.23567" /score="16.9796453" /energy="-16.8" /TU="NA" /idTUdmin="U1373" /TUdmin=0 /isTUend="TRUE" promotor_no_box complement(1859798..1859898) /Source="Nicolas_upshift_promotors" /id="U1372" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.53046953046953" /psig="0.297702297702298" /xcortree=1727 /SigmaFactorBS="ctaagatagatatatagttttagagacaggattacatttcaa atcattctgttttttgtaaactaattcagcaatttgattcatctatttaccctattag g" /listShort="pksS" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1859838) /Source="Nicolas_upshifts" /id="U1372" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.53046953046953" /psig="0.297702297702298" /xcortree=1727 /SigmaFactorBS="ctaagatagatatatagttttagagacaggattacatttcaa atcattctgttttttgtaaactaattcagcaatttgattcatctatttaccctattag g" /listShort="pksS" /GFF_Attribute="listLong" promotor_-10 complement(1859870..1859889) /Source="Nicolas_upshift_promotors" /id="U1373" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=3215 /SigmaFactorBS="gccgttttttcacttttttcgttcttctcccTATTGAATgac gcctaagatagATATATAGTTTTAGAGACAGgattacatttcaaatcattctgttttt t" /listShort="pksS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1859882) /Source="Nicolas_upshifts" /id="U1373" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=3215 /SigmaFactorBS="gccgttttttcacttttttcgttcttctcccTATTGAATgac gcctaagatagATATATAGTTTTAGAGACAGgattacatttcaaatcattctgttttt t" /listShort="pksS" /GFF_Attribute="listLong" S_feature complement(1859884..1859964) /Source="Nicolas_S_feature" /locus_tag="new_1859884_1859964_c" /HighExp="Salt, Etha, T-3.40H, T-0.40H, T-1.40H, LoTm, T-2.40H, S1, SMM, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.122" /TUlongSig="NA" /TUlongPSig="NA" /label="S618" promotor_-35 complement(1859904..1859911) /Source="Nicolas_upshift_promotors" /id="U1373" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=3215 /SigmaFactorBS="gccgttttttcacttttttcgttcttctcccTATTGAATgac gcctaagatagATATATAGTTTTAGAGACAGgattacatttcaaatcattctgttttt t" /listShort="pksS" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1860008) /Source="Nicolas_upshifts" /id="D929" /incds=0 /nref=24 /ntot=184 /MaxReadThrough="3.69744" /MaxDrop="5.18486" /score="-0.71313204" /energy="-20.1" /TU="U1374" /idTUdmin="U1375" /TUdmin=28 /isTUend="FALSE" CDS complement(1860014..1860370) /gene="ymzB" /locus_tag="BSU_17240" /old_locus_tag="BSU17240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11544224, 15805528, 20817675" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function involved in ethanol resistance" /protein_id="NP_389606.3" /db_xref="EnsemblGenomes-Gn:BSU17240" /db_xref="EnsemblGenomes-Tr:CAB13608" /db_xref="SubtiList:BG13435" /db_xref="UniProtKB/Swiss-Prot:O31786" /translation="MAHTNTQLSQWLESKVGQTLDIRKGELTHDEEISDLDQIVLHLQ KVAIRSTNHPDDYVAKEELVLEGEGTTFTEDGNVPLPQNAYEIPLLGELHIHQENEGL KVVTDRAVYTIDIQHS*" gene complement(1860014..1860370) /gene="ymzB" /locus_tag="BSU_17240" /old_locus_tag="BSU17240" misc_feature complement(1860430..1860443) /Source="Nicolas_upshift_promotors" /id="U1374" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.511488511488511" /psig="0.121878121878122" /xcortree=731 /SigmaFactorBS="ccgtacgctatatcaaggcactcaacagcgaactgtttcata cataaagagtGGGGCGGCTCTTTCccgtgtaaaagatgcagcaattgggaatagtatc g" /listShort="ymzB, S618, pksS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1860435) /Source="Nicolas_upshifts" /id="U1374" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.511488511488511" /psig="0.121878121878122" /xcortree=731 /SigmaFactorBS="ccgtacgctatatcaaggcactcaacagcgaactgtttcata cataaagagtGGGGCGGCTCTTTCccgtgtaaaagatgcagcaattgggaatagtatc g" /listShort="ymzB, S618, pksS" /GFF_Attribute="listLong" CDS complement(1860449..1861273) /gene="ymaE" /locus_tag="BSU_17250" /old_locus_tag="BSU17250" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20817675; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389607.2" /db_xref="EnsemblGenomes-Gn:BSU17250" /db_xref="EnsemblGenomes-Tr:CAB13609" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13413" /db_xref="UniProtKB/Swiss-Prot:O31787" /translation="MPYYICNTCGVQHAQTVDPPNSCLICEDERQYIHPDGQTWTTLE DMREKGNLQNILKKEEEHLYSIKTEPEFAIGQTAHLIQHKGFNVLWDCMTYLDQKTID QINELGGIQAIALSHPHYYSTQVEWAEAFQAPIYIHEDDKEWVTRPSNHIHFWSGETL NMKPGLDLYRLGGHFKGGAVLHWSKGNEGKGCLLTGDIITVAADRNWVSFMYSYPNLI PLPASKVEEIAAKVKPLQFNRLYNAFSKVVKENADESVQRSAVRYIKALNSELFHT*" gene complement(1860449..1861273) /gene="ymaE" /locus_tag="BSU_17250" /old_locus_tag="BSU17250" promotor_-10 complement(1861295..1861314) /Source="Nicolas_upshift_promotors" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1861311) /Source="Nicolas_upshifts" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" promotor_-35 complement(1861326..1861332) /Source="Nicolas_upshift_promotors" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1861384..1862712) /gene="aprX" /locus_tag="BSU_17260" /old_locus_tag="BSU17260" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10589719, 16267290, 17884659, 28693413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10589719, 16267290, 17884659, 28693413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkaline serine protease" /protein_id="NP_389608.1" /db_xref="EnsemblGenomes-Gn:BSU17260" /db_xref="EnsemblGenomes-Tr:CAB13610" /db_xref="GOA:O31788" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG12567" /db_xref="UniProtKB/Swiss-Prot:O31788" /translation="MFGYSMVQMVRANAHKLDWPLRETVLQLYKPFKWTPCFLHKFFE TKLQNRKKMSVIIEFEEGCHETGFQMAGEVLQKEKRSKLKSRFNKINCCSAEVTPSAL HSLLSECSNIRKVYLNREVKALLDTATEASHAKEVVRNGQTLTGKGVTVAVVDTGIYP HPDLEGRIIGFADMVNQKTEPYDDNGHGTHCAGDVASSGASSSGQYRGPAPEANLIGV KVLNKQGSGTLADIIEGVEWCIQYNEDNPDEPIDIMSMSLGGDALRYDHEQEDPLVRA VEEAWSAGIVVCVAAGNSGPDSQTIASPGVSEKVITVGALDDNNTASSDDDTVASFSS RGPTVYGKEKPDILAPGVNIISLRSPNSYIDKLQKSSRVGSQYFTMSGTSMATPICAG IAALILQQNPDLTPDEVKELLKNGTDKWKDEDPNIYGAGAVNAENSVPGQ*" gene complement(1861384..1862712) /gene="aprX" /locus_tag="BSU_17260" /old_locus_tag="BSU17260" downshifts complement(1861391) /Source="Nicolas_upshifts" /id="D930" /incds=0 /nref=13 /ntot=21 /MaxReadThrough="2.43809" /MaxDrop="5.8915" /score="10.5332562" /energy="-13" /TU="NA" /idTUdmin="U1376" /TUdmin=8 /isTUend="TRUE" promotor_-10 complement(1862735..1862754) /Source="Nicolas_upshift_promotors" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1862754) /Source="Nicolas_upshifts" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" promotor_-35 complement(1862768..1862776) /Source="Nicolas_upshift_promotors" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1862869..1862876 /Source="Nicolas_upshift_promotors" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1862884..1862903) /Source="Nicolas_upshift_promotors" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1862892..1862911 /Source="Nicolas_upshift_promotors" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1862895) /Source="Nicolas_upshifts" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" upshifts 1862898 /Source="Nicolas_upshifts" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" promotor_-35 complement(1862916..1862923) /Source="Nicolas_upshift_promotors" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1862937..1863014 /gene="ymzEn" /locus_tag="BSU_17266" /old_locus_tag="BSU17266" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; N-terminal part of YmzE" /translation="MNFYLHRSLESQMPISIIYEERRND*" gene 1862937..1863014 /gene="ymzEn" /locus_tag="BSU_17266" /old_locus_tag="BSU17266" /pseudo downshifts complement(1862939) /Source="Nicolas_upshifts" /id="D931" /incds=0 /nref=4 /ntot=7 /MaxReadThrough="1.51659" /MaxDrop="5.37668" /score="10.5332562" /energy="-13" /TU="NA" /idTUdmin="U1377" /TUdmin="-462" /isTUend="FALSE" CDS 1862992..1863168 /gene="ymzEc" /locus_tag="BSU_17267" /old_locus_tag="BSU17267" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; C-terminal part of YmzE" /db_xref="PSEUDO:CAX52622.1" /translation="MKKDGTISKRTIIVRQKSKTKIKAFCFSKQQIRTFLLDSILSCD FVRTNKQNLYSAGR*" gene 1862992..1863168 /gene="ymzEc" /locus_tag="BSU_17267" /old_locus_tag="BSU17267" /pseudo downshifts 1863149 /Source="Nicolas_upshifts" /id="D932" /incds=0 /nref=42 /ntot=207 /MaxReadThrough="4.03151" /MaxDrop="6.55778" /score="-0.929304655" /energy="-5.5" /TU="U1378" /idTUdmin="U1378" /TUdmin="-1496" /isTUend="FALSE" S_feature 1863194..1863382 /Source="Nicolas_S_feature" /locus_tag="new_1863194_1863382" /HighExp="H2O2, M40t90, C90, M40t45, C30, S8, HiOs, G135, T-4.40H, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S619" misc_feature 1863377..1863396 /Source="Nicolas_upshift_promotors" /id="U1379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.44955044955045" /psig=1 /xcortree=2371 /SigmaFactorBS="atcaattgattttttgaaaccgggaactttttcactgatgat attgtgtatacAATGGTAAGATAAAACCTATtggctaaacctcatataatgaaccgcg c" /listShort="ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1863384 /Source="Nicolas_upshifts" /id="U1379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.44955044955045" /psig=1 /xcortree=2371 /SigmaFactorBS="atcaattgattttttgaaaccgggaactttttcactgatgat attgtgtatacAATGGTAAGATAAAACCTATtggctaaacctcatataatgaaccgcg c" /listShort="ymaC, ymaD" /GFF_Attribute="listLong" CDS 1863448..1864155 /gene="pghC" /locus_tag="BSU_17270" /old_locus_tag="BSU17270" /EC_number="3.4.19.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 16267290, 26158264; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="gamma-polyglutamate hydrolase (phage origin)" /protein_id="NP_389609.1" /db_xref="EnsemblGenomes-Gn:BSU17270" /db_xref="EnsemblGenomes-Tr:CAB13611" /db_xref="GOA:O31789" /db_xref="InterPro:IPR008585" /db_xref="SubtiList:BG13411" /db_xref="UniProtKB/Swiss-Prot:O31789" /translation="MRRFLLNVILVLAIVLFLRYVHYSLEPEPSNQPDTYSNFSSLAE NESPADYDISYNEKKGSKVLIMSPHGGRIEGGVSELVRYFNNEYSTYLFEGLKSHDNQ TLHITSTNFDEPLAKKKIKEHQYVVAFHGYKGENKNTLVGGTDRKRAKMIVRALERRG FSAELASSKSGLAGLNAENINNQGETGLSIQLEISREQREAFFDDFYYKNRKYTKNSE FYAYVSAIKGVLEKEYS*" gene 1863448..1864155 /gene="pghC" /locus_tag="BSU_17270" /old_locus_tag="BSU17270" promotor_-35 1864166..1864172 /Source="Nicolas_upshift_promotors" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1864186..1864205 /Source="Nicolas_upshift_promotors" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1864190 /Source="Nicolas_upshifts" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" CDS 1864225..1864677 /gene="ymaD" /locus_tag="BSU_17280" /old_locus_tag="BSU17280" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290, 22904090, 25649915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peroxiredoxin-related protein" /protein_id="NP_389610.1" /db_xref="EnsemblGenomes-Gn:BSU17280" /db_xref="EnsemblGenomes-Tr:CAB13612" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019905" /db_xref="InterPro:IPR036102" /db_xref="SubtiList:BG13412" /db_xref="UniProtKB/Swiss-Prot:O31790" /translation="MADHHFYLKANWPGNRNDVGTIESGNLITSISIPKEMDGPGEGT NPDEMLLGAAATCYIITLAAMMERSGLEKEDLQMESEGIVNVTKGVFTYKKIIHRPSV VLKHDASQDDVALAHKLCKKAESSCMISRAIQGNVELQLEASVKLGGE*" gene 1864225..1864677 /gene="ymaD" /locus_tag="BSU_17280" /old_locus_tag="BSU17280" downshifts 1864665 /Source="Nicolas_upshifts" /id="D933" /incds=0 /nref=44 /ntot=182 /MaxReadThrough="1.35366" /MaxDrop="6.07534" /score="17.0193804" /energy="-12.1" /TU="NA" /idTUdmin="U1379" /TUdmin="-2" /isTUend="TRUE" CDS complement(1864691..1865044) /gene="ebrB" /locus_tag="BSU_17290" /old_locus_tag="BSU17290" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735876, 15849754, 16750162, 16850406, 18024586, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735876, 15849754, 16750162, 16850406, 18024586, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small toxic metabolite efflux transporter subunit" /protein_id="NP_389611.1" /db_xref="EnsemblGenomes-Gn:BSU17290" /db_xref="EnsemblGenomes-Tr:CAB13613" /db_xref="GOA:P0CW82" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12586" /db_xref="UniProtKB/Swiss-Prot:P0CW82" /translation="MRGLLYLALAIVSEVFGSTMLKLSEGFTQAWPIAGVIVGFLSAF TFLSFSLKTIDLSSAYATWSGVGTALTAIVGFLLFGETISLKGVFGLTLVIAGVVVLN QSKAHAEDKKQTACE*" gene complement(1864691..1865044) /gene="ebrB" /locus_tag="BSU_17290" /old_locus_tag="BSU17290" downshifts complement(1864732) /Source="Nicolas_upshifts" /id="D934" /incds=0 /nref=2 /ntot=45 /MaxReadThrough="0.84905" /MaxDrop="2.87924" /score="-2.89884673" /energy="-8.7" /TU="NA" /idTUdmin="U1381" /TUdmin="-11" /isTUend="TRUE" CDS complement(1865058..1865375) /gene="ebrA" /locus_tag="BSU_17300" /old_locus_tag="BSU17300" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735876, 11104814, 17516673, 18024586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735876, 11104814, 17516673, 18024586; Product type t: transporter" /codon_start=1 /transl_table=11 /product="small toxic metabolite efflux transporter subunit" /protein_id="NP_389612.1" /db_xref="EnsemblGenomes-Gn:BSU17300" /db_xref="EnsemblGenomes-Tr:CAB13614" /db_xref="GOA:P0CW80" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12585" /db_xref="UniProtKB/Swiss-Prot:P0CW80" /translation="MLIGYIFLTIAICSESIGAAMLKVSDGFKKWKPSALVVIGYSLA FYMLSLTLNHIPLSLSYATWSGAGTVLTTVIGVKWFKEDLNAKGLIGILLLLSGVVLL NWP*" gene complement(1865058..1865375) /gene="ebrA" /locus_tag="BSU_17300" /old_locus_tag="BSU17300" promotor_-10 complement(1865419..1865438) /Source="Nicolas_upshift_promotors" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1865427) /Source="Nicolas_upshifts" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" promotor_-35 complement(1865453..1865460) /Source="Nicolas_upshift_promotors" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1865512..1865787) /gene="ymaG" /locus_tag="BSU_17310" /old_locus_tag="BSU17310" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19775244, 19933362, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19775244, 19933362, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein; cell wall associated protein" /protein_id="NP_389613.2" /db_xref="EnsemblGenomes-Gn:BSU17310" /db_xref="EnsemblGenomes-Tr:CAB13615" /db_xref="GOA:O31793" /db_xref="SubtiList:BG13415" /db_xref="UniProtKB/Swiss-Prot:O31793" /translation="MNELEHFSPEDTRIFGRPFGFGRPFGFGRPFGFGYGFGRPGFGY GFGRPFGFFGGPFIGGLAGGLIGSALFNPYLYGGYPYYPYAPFPFYY*" gene complement(1865512..1865787) /gene="ymaG" /locus_tag="BSU_17310" /old_locus_tag="BSU17310" downshifts complement(1865513) /Source="Nicolas_upshifts" /id="D935" /incds=0 /nref=38 /ntot=44 /MaxReadThrough="0.28059" /MaxDrop="8.33353" /score="12.3408391" /energy="-11.5" /TU="NA" /idTUdmin="U1383" /TUdmin=0 /isTUend="TRUE" promotor_-35 1865783..1865788 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-35" promotor_-10 1865804..1865822 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-10" promotor_-10 complement(1865814..1865833) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1865824 /Source="Nicolas_upshifts" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" upshifts complement(1865827) /Source="Nicolas_upshifts" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" promotor_-35 complement(1865846..1865855) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1865876..1866289 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24098137, 25915524" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein of unknown function" /protein_id="NP_389614.2" /db_xref="EnsemblGenomes-Gn:BSU17320" /db_xref="EnsemblGenomes-Tr:CAB13616" /db_xref="InterPro:IPR024307" /db_xref="SubtiList:BG13414" /db_xref="UniProtKB/Swiss-Prot:O31794" /translation="MNTLGLYQSDWSKAPPHAHAYHVKTTREQGHYHLIEGFTQPANG SNTDQHTHYYTGITSFENGHFHRYYGISGPAIPLADGTHYHEIEETTYLAYNEPIEIQ YGGVVYDPGDDRRKTHRHTLKGKTREIVGNEPLGW*" gene 1865876..1866289 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" upshifts 1866340 /Source="Nicolas_upshifts" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" misc_feature 1866346..1866365 /Source="Nicolas_upshift_promotors" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1866389..1867333 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" /EC_number="2.5.1.75" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3045085, 11160115, 26735940, 28277934, 28471404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA isopentenylpyrophosphate transferase" /protein_id="NP_389615.2" /db_xref="EnsemblGenomes-Gn:BSU17330" /db_xref="EnsemblGenomes-Tr:CAB13617" /db_xref="GOA:O31795" /db_xref="InterPro:IPR018022" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12617" /db_xref="UniProtKB/Swiss-Prot:O31795" /translation="MNNTKQPVVILVGPTAVGKTNLSIQLAKSLNAEIISGDSMQIYK GMDIGTAKITEQEMEGVPHHLIDILDPQDSFSTADYQSLVRNKISEIANRGKLPMIVG GTGLYIQSVLYDYTFTEEANDPVFRESMQMAAEREGADFLHAKLAAADPEAAAAIHPN NTRRVIRALEILHTSGKTMSQHLKEQKRELLYNAVLIGLTMDRDTLYERINQRVDLMM QSGLLPEVKRLYDKNVRDCQSIQAIGYKELYAYFDGFVTLSDAVEQLKQNSRRYAKRQ LTWFRNKMQVTWFDMTPPVDMELKKKEIFTHIAGKLEL*" gene 1866389..1867333 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" promotor_-35 1867313..1867321 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-35" promotor_-10 1867332..1867350 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-10" upshifts 1867334 /Source="Nicolas_upshifts" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" CDS 1867373..1867594 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927; Product type f: factor" /codon_start=1 /transl_table=11 /product="Hfq RNA chaperone" /protein_id="NP_389616.1" /db_xref="EnsemblGenomes-Gn:BSU17340" /db_xref="EnsemblGenomes-Tr:CAB13618" /db_xref="GOA:O31796" /db_xref="InterPro:IPR005001" /db_xref="InterPro:IPR010920" /db_xref="PDB:3AHU" /db_xref="PDB:3HSB" /db_xref="SubtiList:BG13416" /db_xref="UniProtKB/Swiss-Prot:O31796" /translation="MKPINIQDQFLNQIRKENTYVTVFLLNGFQLRGQVKGFDNFTVL LESEGKQQLIYKHAISTFAPQKNVQLELE*" gene 1867373..1867594 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" downshifts complement(1867384) /Source="Nicolas_upshifts" /id="D936" /incds=0 /nref=3 /ntot=108 /MaxReadThrough="1.19472" /MaxDrop="3.56162" /score="-5.83707008" /energy="-5.2" /TU="NA" /idTUdmin="U1386" /TUdmin=22 /isTUend="TRUE" promotor_-10 complement(1867446..1867450) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1867450) /Source="Nicolas_upshifts" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1867465..1867470) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1867594 /Source="Nicolas_upshifts" /id="D937" /incds=0 /nref=26 /ntot=212 /MaxReadThrough="5.10866" /MaxDrop="4.06475" /score="17.2354231" /energy="-17" /TU="U1382,U1385" /idTUdmin="U1384" /TUdmin=0 /isTUend="TRUE" CDS 1867790..1868062 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389617.1" /db_xref="EnsemblGenomes-Gn:BSU17350" /db_xref="EnsemblGenomes-Tr:CAB13619" /db_xref="InterPro:IPR025448" /db_xref="PDB:3KVP" /db_xref="SubtiList:BG13436" /db_xref="UniProtKB/Swiss-Prot:O31797" /translation="MFESEAELRRIRIALVWIAVFLLFGACGNQDTIIETDNGNSDYE TPQPTSFPLEHNHFGVMEDGYIKIYEYNESRNEVKLKKEYADDELE*" gene 1867790..1868062 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" promotor_-35 1868078..1868085 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1868099..1868118 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1868101 /Source="Nicolas_upshifts" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" CDS 1868144..1868374 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389618.1" /db_xref="EnsemblGenomes-Gn:BSU17360" /db_xref="EnsemblGenomes-Tr:CAB13620" /db_xref="SubtiList:BG13434" /db_xref="UniProtKB/Swiss-Prot:O31798" /translation="MKHKVIVNHWEEICEDDSCYEYGTSIIVNGKELIREASIITALK AVLEEIGADVEIEETVESEKCCDSLRKKNLDY*" gene 1868144..1868374 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" S_feature 1868375..1868451 /Source="Nicolas_S_feature" /locus_tag="new_1868375_1868451" /HighExp="dia5, dia15, Diami, B60, G150, H2O2, LPhT, G180, G135, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S620" downshifts 1868408 /Source="Nicolas_upshifts" /id="D938" /incds=0 /nref=24 /ntot=61 /MaxReadThrough="7.47169" /MaxDrop="4.19691" /score="8.2587309" /energy="-16.9" /TU="U1385,U1387" /idTUdmin="U1385" /TUdmin="-132" /isTUend="FALSE" S_feature 1868453..1868560 /Source="Nicolas_S_feature" /locus_tag="new_1868453_1868560" /HighExp="G180, G150, G135, H2O2, dia15, Paraq, LBGexp, C30, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S621" promotor_-35 1868533..1868540 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1868554..1868573 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1868562 /Source="Nicolas_upshifts" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" CDS 1868617..1869009 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16885274, 21561096, 22443445, 23402532, 26507228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16885274, 21561096, 22443445, 23402532, 26507228; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-factor of ribonucleotide diphosphate reductase" /protein_id="NP_389619.1" /db_xref="EnsemblGenomes-Gn:BSU17370" /db_xref="EnsemblGenomes-Tr:CAB13621" /db_xref="GOA:P50618" /db_xref="InterPro:IPR004465" /db_xref="InterPro:IPR020852" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLJ" /db_xref="SubtiList:BG11426" /db_xref="UniProtKB/Swiss-Prot:P50618" /translation="MVQIIFDSKTGNVQRFVNKTGFQQIRKVDEMDHVDTPFVLVTYT TNFGQVPASTQSFLEKYAHLLLGVAASGNKVWGDNFAKSADTISRQYQVPILHKFELS GTSKDVELFTQEVERVVTKSSAKMDPVK*" gene 1868617..1869009 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" CDS 1868969..1871071 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (major subunit)" /protein_id="NP_389620.1" /db_xref="EnsemblGenomes-Gn:BSU17380" /db_xref="EnsemblGenomes-Tr:CAB13622" /db_xref="GOA:P50620" /db_xref="InterPro:IPR000788" /db_xref="InterPro:IPR008926" /db_xref="InterPro:IPR013346" /db_xref="InterPro:IPR013509" /db_xref="InterPro:IPR013554" /db_xref="InterPro:IPR026459" /db_xref="SubtiList:BG11404" /db_xref="UniProtKB/Swiss-Prot:P50620" /translation="MSQNQVPKWIQLNNEIMIQKDGKFQFDKDKEAVHSYFVDYINQN TVFFHNLKEKLDYLVENQYYEEEFLSLYSFEDIKEVFKTAYAKKFRFPSFMSAFKFYN DYALKTNDKKKILERYEDRISIVALFFANGDTEKAKEYVNLMINQEYQPSTPTFLNAG RKRRGELVSCFLLEVNDSLNDISRAIDISMQLSKLGGGVSLNLSKLRAKGEAIKDVEN ATKGVVGVMKLLDNAFRYADQMGQRQGSGAAYLNIFHRDINDFLDTKKISADEDVRVK TLSIGVVIPDKFVELAREDKAAYVFYPHTIYKEYGQHMDEMDMNEMYDKFVDNPRVKK EKINPRKLLEKLAMLRSESGYPYIMFQDNVNKVHANNHISKVKFSNLCSEVLQASQVS SYTDYDEEDEIGLDISCNLGSLNILNVMEHKSIEKTVKLATDSLTHVSETTDIRNAPA VRRANKAMKSIGLGAMNLHGYLAQNGIAYESPEARDFANTFFMMVNFYSIQRSAEIAK EKGETFDQYEGSTYATGEYFDKYVSTDFSPKYEKIANLFEGMHIPTTEDWKKLKAFVA EHGMYHSYRLCIAPTGSISYVQSSTASVMPIMERIEERTYGNSKTYYPMPGLASNNWF FYKEAYDMDMFKVVDMIATIQQHIDQGISFTLFLKDTMTTRDLNRIDLYAHHRGIKTI YYARTKDTGQDSCLSCVV*" gene 1868969..1871071 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" CDS 1871089..1872078 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (minor subunit)" /protein_id="NP_389621.1" /db_xref="EnsemblGenomes-Gn:BSU17390" /db_xref="EnsemblGenomes-Tr:CAB13623" /db_xref="GOA:P50621" /db_xref="InterPro:IPR000358" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR026494" /db_xref="InterPro:IPR030475" /db_xref="InterPro:IPR033909" /db_xref="PDB:4DR0" /db_xref="SubtiList:BG11405" /db_xref="UniProtKB/Swiss-Prot:P50621" /translation="MTKIYDAANWSKHEDDFTQMFYNQNVKQFWLPEEIALNGDLLTW KYLGKNEQDTYMKVLAGLTLLDTEQGNTGMPIVAEHVDGHQRKAVLNFMAMMENAVHA KSYSNIFMTLAPTETINEVFEWVKQNKYLQKKAQMIVGLYKAIQKDDEISLFKAMVAS VYLESFLFYSGFYYPLYFYGQGKLMQSGEIINLILRDEAIHGVYVGLLAQEIYNKQTE EKKAELREFAIDLLNQLYENELEYTEDLYDQVGLSHDVKKFIRYNANKALMNLGFDPY FEEEDINPIVLNGLNTKTKSHDFFSMKGNGYKKATVEPLKDDDFYFEDEKEQI*" gene 1871089..1872078 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" downshifts 1872038 /Source="Nicolas_upshifts" /id="D939" /incds=0 /nref=3 /ntot=106 /MaxReadThrough="6.49299" /MaxDrop="2.8143" /score="-8.26008921" /energy="-10.8" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-726" /isTUend="FALSE" S_feature complement(1872092..1872751) /Source="Nicolas_S_feature" /locus_tag="new_1872092_1872751_c" /HighExp="BT, B36, C30, Pyr, S8, G135, G/S, Glucon, B60, C90" /AntisenseName="ymaB" /AntisenseCor="-0.136438199650502" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S622" downshifts complement(1872107) /Source="Nicolas_upshifts" /id="D940" /incds=0 /nref=3 /ntot=8 /MaxReadThrough="2.78803" /MaxDrop="4.0424" /score="6.77419677" /energy="-10.8" /TU="NA" /idTUdmin="U1390" /TUdmin=7 /isTUend="TRUE" CDS 1872128..1872748 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885274, 21561096; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative cofactor involved in deoxyribonucleotide synthesis" /protein_id="NP_389622.1" /db_xref="EnsemblGenomes-Gn:BSU17400" /db_xref="EnsemblGenomes-Tr:CAB13624" /db_xref="GOA:P50619" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG11427" /db_xref="UniProtKB/Swiss-Prot:P50619" /translation="MGKMDEMILVAPRDDVFKKESLTFQGVYSEDSRVAEIMAQIEAA YREMRRGDAEEDPRFKQPIPYVVIKREDEVFLYERLAGGGESRLHNKLSLGFGGHMNA IEGAASFAEVLKLNTDRELEEELQINEEDKQAIVTLGLINDDENSVGKVHIGILSALQ LKPGAQVEVKEKEQIAGKWMKVSELKQDDIYNRLETWSQFVVDILE*" gene 1872128..1872748 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" downshifts 1872729 /Source="Nicolas_upshifts" /id="D941" /incds=0 /nref=130 /ntot=257 /MaxReadThrough="4.3301" /MaxDrop="6.0751" /score="31.3992458" /energy="-16.3" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-35" /isTUend="FALSE" promotor_-35 1872764..1872768 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1872786..1873153 /Source="Nicolas_S_feature" /locus_tag="new_1872786_1873153" /HighExp="dia15, G180, H2O2, G135, G150, Diami, Paraq, Oxctl, LBGexp, C30" /AntisenseName="cwlC" /AntisenseCor="-8.9131707018362205E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.231, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S623" upshifts 1872786 /Source="Nicolas_upshifts" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" promotor_-10 1872790..1872807 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1872796) /Source="Nicolas_upshifts" /id="D942" /incds=0 /nref=1 /ntot=53 /MaxReadThrough="7.25519" /MaxDrop="4.6417" /score="9.14776993" /energy="-8.9" /TU="U1390" /idTUdmin="U1390" /TUdmin="-682" /isTUend="FALSE" CDS complement(1872812..1873579) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" /EC_number="3.5.1.28" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10515909, 10945275, 10974124, 11375403, 16042392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10515909, 10945275, 10974124, 11375403, 16042392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (sporulation-specific)" /protein_id="NP_389623.2" /db_xref="EnsemblGenomes-Gn:BSU17410" /db_xref="EnsemblGenomes-Tr:CAB13625" /db_xref="GOA:Q06320" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="PDB:1X60" /db_xref="SubtiList:BG10825" /db_xref="UniProtKB/Swiss-Prot:Q06320" /translation="MVKIFIDPGHGGSDPGATGNGLQEKTLTLQIALALRTILTNEYE GVSLLLSRTSDQYVSLNDRTNAANNWGADFFLSIHVNSGGGTGFESYIYPDVGAPTTT YQSTIHSEVIQAVDFADRGKKTANFHVLRESAMPALLTENGFIDTVSDANKLKTSSFI QSLARGHANGLEQAFNLKKTSSSGLYKVQIGAFKVKANADSLASNAEAKGFDSIVLLK DGLYKVQIGAFSSKDNADTLAARAKNAGFDAIVILES*" gene complement(1872812..1873579) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" promotor_-10 complement(1873588..1873607) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1873611) /Source="Nicolas_upshifts" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" promotor_-35 complement(1873620..1873629) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1873733..1873738 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1873754..1873772 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1873754 /Source="Nicolas_upshifts" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 1874036..1874041 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-35" promotor_-10 1874058..1874076 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-10" S_feature 1874062..1874202 /Source="Nicolas_S_feature" /locus_tag="new_1874062_1874202" /HighExp="S4, S5, S6, S8, S3, B60, LoTm, S7, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.777" /TUlongSig="NA" /TUlongPSig="NA" /label="S624" upshifts 1874062 /Source="Nicolas_upshifts" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" CDS 1874203..1875171 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8464402, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8464402, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="mother cell sporulation ATPase" /protein_id="NP_389624.2" /db_xref="EnsemblGenomes-Gn:BSU17420" /db_xref="EnsemblGenomes-Tr:CAB13626" /db_xref="GOA:P27643" /db_xref="InterPro:IPR000641" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR014232" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11039" /db_xref="UniProtKB/Swiss-Prot:P27643" /translation="MLERAVTYKNNGQINIILNGQKQVLTNAEAEAEYQAALQKNEAK HGILKEIEKEMSALVGMEEMKRNIKEIYAWIFVNQKRAEQGLKVGKQALHMMFKGNPG TGKTTVARLIGKLFFEMNVLSKGHLIEAERADLVGEYIGHTAQKTRDLIKKSLGGILF IDEAYSLARGGEKDFGKEAIDTLVKHMEDKQHEFILILAGYSREMDHFLSLNPGLQSR FPISIDFPDYSVTQLMEIAKRMIDEREYQLSQEAEWKLKDYLMTVKSTTSPIKFSNGR FVRNVIEKSIRAQAMRLLMGDQYLKSDLMTIKSQDLSIKEEASGSA*" gene 1874203..1875171 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" downshifts 1875140 /Source="Nicolas_upshifts" /id="D943" /incds=0 /nref=5 /ntot=41 /MaxReadThrough="2.7881" /MaxDrop="5.20495" /score="22.9164064" /energy="-15.5" /TU="U1392" /idTUdmin="U1392" /TUdmin="-109" /isTUend="FALSE" promotor_-35 1875235..1875243 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-35" upshifts 1875250 /Source="Nicolas_upshifts" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" promotor_-10 1875254..1875273 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-10" CDS 1875304..1876566 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19824612, 26458047, 26733579, 26951678, 27398305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-splitting GTPase (also ATPase, rescuingstalled ribosomes, E-site binding)" /protein_id="NP_389625.2" /db_xref="EnsemblGenomes-Gn:BSU17430" /db_xref="EnsemblGenomes-Tr:CAB13627" /db_xref="GOA:P94478" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016496" /db_xref="InterPro:IPR025121" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030394" /db_xref="InterPro:IPR032305" /db_xref="SubtiList:BG12263" /db_xref="UniProtKB/Swiss-Prot:P94478" /translation="MNEQETIQEKAILVGCQLPHITDEHFENSMEELASLTKTADGKV LTSVTQKRNRADAATYIGKGKVEELKALVEELEADLLIFNDELSPSQLKSLATAIEVK MIDRTQLILDIFAKRARTREGKLQIELAQLQYALPRLTGQGINLSRQGGGIGARGPGE TKLETDRRHIRNRIHEINTQLSTVIRHRSRYRERRKKNGVLQIALVGYTNAGKSTWFN RLTSADSYEEDLLFATLDPMTRKMVLPSGYSVLLSDTVGFIQDLPTTLIAAFRSTLEE VKEADLILHLIDSSNEDYAGHEKTVLRLLEELEADDIPMLTAYNKRDQKLPDFIPTAG RDHIMVSAKFEDDAAAFKEAIQRYLRQELLTSFEAHVPASEGKLLSRIKSETMVDRFY FNEENEQYDISGYVQEEQSIIGELKKYM*" gene 1875304..1876566 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" CDS 1876584..1877849 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 24610841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_389626.2" /db_xref="EnsemblGenomes-Gn:BSU17440" /db_xref="EnsemblGenomes-Tr:CAB13628" /db_xref="GOA:P94479" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR009651" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12264" /db_xref="UniProtKB/Swiss-Prot:P94479" /translation="MFDTLTHGELLKKTAMEVEADIAGIHKQIEEISERNEWRVLQSY RKHKVSDTHFTPSTGYGYDDIGRDTLESIYADVFGGEAGLVRPQIISGTHAISIALFG VLRPGDELLYITGKPYDTLEEIVGVRGGENAGSLKDFQIGYNAVDLTKDGKIDYDAVA AAINPKTKVIGIQRSKGYANRPSFLISEIKEMIRFVKEINENLIVFVDNCYGEFVEEL EPCHVGADLMAGSLIKNPGGGLAKTGGYLVGKAKWIEACSYRMTSPGIGREAGASLYS LQEMYQGFFLAPHVVSQSLKGAVFTARFLEKLGFTSNPKWDAKRTDLIQSVEFSDREK MIAFCQAIQFASPINAHVTPYPAYMPGYEDDVIMAAGTFIQGASIELSADGPIRPPYV AYVQGGLTYSHVKNAICSAVDSLMQKQLI*" gene 1876584..1877849 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" promotor_-35 1877897..1877904 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-35" promotor_-10 1877919..1877938 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-10" upshifts 1877931 /Source="Nicolas_upshifts" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" CDS 1877959..1878366 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (nitrogen metabolism)" /protein_id="NP_389627.1" /db_xref="EnsemblGenomes-Gn:BSU17450" /db_xref="EnsemblGenomes-Tr:CAB13629" /db_xref="GOA:P37582" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4R4E" /db_xref="SubtiList:BG10424" /db_xref="UniProtKB/Swiss-Prot:P37582" /translation="MSDNIRRSMPLFPIGIVMQLTELSARQIRYYEENGLIFPARSEG NRRLFSFHDVDKLLEIKHLIEQGVNMAGIKQILAKAEAEPEQKQNEKTKKPMKHDLSD DELRQLLKNELMQAGRFQRGNTFRQGDMSRFFH*" gene 1877959..1878366 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" downshifts complement(1877965) /Source="Nicolas_upshifts" /id="D944" /incds=0 /nref=2 /ntot=82 /MaxReadThrough="1.78139" /MaxDrop="3.45896" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3816 /isTUend="FALSE" misc_feature 1878347..1878365 /Source="Nicolas_upshift_promotors" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1878372 /Source="Nicolas_upshifts" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" downshifts complement(1878425) /Source="Nicolas_upshifts" /id="D945" /incds=0 /nref=1 /ntot=72 /MaxReadThrough="1.70567" /MaxDrop="3.42395" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3356 /isTUend="FALSE" CDS 1878425..1879759 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" /EC_number="6.3.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine synthetase" /protein_id="NP_389628.1" /db_xref="EnsemblGenomes-Gn:BSU17460" /db_xref="EnsemblGenomes-Tr:CAB13630" /db_xref="GOA:P12425" /db_xref="InterPro:IPR001637" /db_xref="InterPro:IPR004809" /db_xref="InterPro:IPR008146" /db_xref="InterPro:IPR008147" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR027302" /db_xref="InterPro:IPR027303" /db_xref="InterPro:IPR036651" /db_xref="PDB:2FWX" /db_xref="PDB:4LNF" /db_xref="PDB:4LNI" /db_xref="PDB:4LNK" /db_xref="PDB:4LNN" /db_xref="PDB:4LNO" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG10425" /db_xref="UniProtKB/Swiss-Prot:P12425" /translation="MAKYTREDIEKLVKEENVKYIRLQFTDILGTIKNVEIPVSQLGK ALDNKVMFDGSSIEGFVRIEESDMYLYPDLNTFVIFPWTAEKGKVARFICDIYNPDGT PFEGDPRNNLKRILKEMEDLGFSDFNLGPEPEFFLFKLDEKGEPTLELNDKGGYFDLA PTDLGENCRRDIVLELEEMGFEIEASHHEVAPGQHEIDFKYAGAVRSCDDIQTFKLVV KTIARKHGLHATFMPKPLFGVNGSGMHCNLSLFKNGVNAFFDENADLQLSETAKHFIA GIVKHATSFTAVTNPTVNSYKRLVPGYEAPCYVAWSAQNRSPLIRIPASRGISTRVEV RSVDPAANPYLALSVLLAAGLDGIKNKLEAPAPIDRNIYVMSKEERMENGIVDLPATL AEALEEFKSNEVMVKALGEHLFEHFIEAKEIEWDMFRTQVHPWEREQYMSQY*" gene 1878425..1879759 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" downshifts 1879736 /Source="Nicolas_upshifts" /id="D946" /incds=0 /nref=266 /ntot=287 /MaxReadThrough="5.53201" /MaxDrop="7.28613" /score="29.7599306" /energy="-16.4" /TU="U1394,U1395" /idTUdmin="U1393" /TUdmin=1 /isTUend="TRUE" S_feature 1879781..1880041 /Source="Nicolas_S_feature" /locus_tag="new_1879781_1880041" /HighExp="Cold, BT, LBGtran, G135, G180, Etha, G150, LBGexp, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.777, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S625" promotor_-35 1880016..1880023 /Source="Nicolas_upshift_promotors" /id="U1396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig="0.997002997002997" /xcortree=3171 /SigmaFactorBS="agcaataataagatgagtaaggtagatgtttatCATTGACAt cataaccaaatgaATCCATAATTACGTTGAAATctaaatcaattttcaaaaaggagat t" /listShort="ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-35" promotor_-10 1880038..1880057 /Source="Nicolas_upshift_promotors" /id="U1396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig="0.997002997002997" /xcortree=3171 /SigmaFactorBS="agcaataataagatgagtaaggtagatgtttatCATTGACAt cataaccaaatgaATCCATAATTACGTTGAAATctaaatcaattttcaaaaaggagat t" /listShort="ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-10" upshifts 1880043 /Source="Nicolas_upshifts" /id="U1396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig="0.997002997002997" /xcortree=3171 /SigmaFactorBS="agcaataataagatgagtaaggtagatgtttatCATTGACAt cataaccaaatgaATCCATAATTACGTTGAAATctaaatcaattttcaaaaaggagat t" /listShort="ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" CDS 1880087..1880377 /gene="ynxB" /locus_tag="BSU_17470" /old_locus_tag="BSU17470" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; defective, phage region" /protein_id="NP_389629.1" /db_xref="EnsemblGenomes-Gn:BSU17470" /db_xref="EnsemblGenomes-Tr:CAB13631" /db_xref="GOA:P31844" /db_xref="SubtiList:BG11074" /db_xref="UniProtKB/Swiss-Prot:P31844" /translation="MKKLTIFSGGLGAVFSVLAQLFAVIDDSYTLGNLWFLGALAGII TMLASIQTNNKPVFSILLIASSVIGLLGTGLVYIIPTLFNIIIIYKFSKVSQ*" gene 1880087..1880377 /gene="ynxB" /locus_tag="BSU_17470" /old_locus_tag="BSU17470" S_feature 1880378..1880622 /Source="Nicolas_S_feature" /locus_tag="new_1880378_1880622" /HighExp="Cold, M9-stat, BC, B60, LPhT, T0.30H, LBGstat, LoTm, S4, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.49198399999999998" /TUshortSig="SigA, SigL, SigA" /TUshortPSig="0.997, 0.777, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S626" CDS 1880623..1880967 /gene="ynzF" /locus_tag="BSU_17480" /old_locus_tag="BSU17480" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; defective phage region" /protein_id="NP_389630.1" /db_xref="EnsemblGenomes-Gn:BSU17480" /db_xref="EnsemblGenomes-Tr:CAB13632" /db_xref="SubtiList:BG13469" /db_xref="UniProtKB/Swiss-Prot:O31799" /translation="MWKALSQLLKKQKNQSPSDEDYIQIPELEVKVLGMLHSINIDLV NVIAQAEKSKEFIGQIEGIWHSIANQFYSLAQGFENEDINKLSADLDHAAATWEAVAN KAKEFVTNSYQG*" gene 1880623..1880967 /gene="ynzF" /locus_tag="BSU_17480" /old_locus_tag="BSU17480" downshifts 1880945 /Source="Nicolas_upshifts" /id="D947" /incds=0 /nref=31 /ntot=125 /MaxReadThrough="3.06401" /MaxDrop="4.27622" /score="-0.54122646" /energy="-8.3" /TU="U1394,U1396" /idTUdmin="U1394" /TUdmin="-440" /isTUend="FALSE" CDS 1881098..1881349 /gene="ynzG" /locus_tag="BSU_17490" /old_locus_tag="BSU17490" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; defective phage region" /protein_id="NP_389631.1" /db_xref="EnsemblGenomes-Gn:BSU17490" /db_xref="EnsemblGenomes-Tr:CAB13633" /db_xref="SubtiList:BG13470" /db_xref="UniProtKB/Swiss-Prot:O31800" /translation="MLGINVEKSNENLIINWQLSKIEIPIKEINDVFLDPNYGGEEKS AVRIGFPYGSTDRVVIKTARNTYILFTTNPALIMSKIVS*" gene 1881098..1881349 /gene="ynzG" /locus_tag="BSU_17490" /old_locus_tag="BSU17490" promotor_-35 1881375..1881382 /Source="Nicolas_upshift_promotors" /id="U1397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=3172 /SigmaFactorBS="ttaataaacagtttatgtcccttttaaatTTATCTATtaatg ttctgTGTGGTAAAATTTAGTGAGAtgatttaaggaggaggagcatttatggaagaaa t" /listShort="S627, ynaB, ynaC, ynaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1881393..1881412 /Source="Nicolas_upshift_promotors" /id="U1397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=3172 /SigmaFactorBS="ttaataaacagtttatgtcccttttaaatTTATCTATtaatg ttctgTGTGGTAAAATTTAGTGAGAtgatttaaggaggaggagcatttatggaagaaa t" /listShort="S627, ynaB, ynaC, ynaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1881406..1881535 /Source="Nicolas_S_feature" /locus_tag="new_1881406_1881535" /HighExp="LoTm, Etha, LPhT, B60, M9-stat, T3.0H, T3.30H, Salt, T4.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.968584" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA" /TUlongPSig="0.997, 1, 1" /label="S627" upshifts 1881406 /Source="Nicolas_upshifts" /id="U1397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=3172 /SigmaFactorBS="ttaataaacagtttatgtcccttttaaatTTATCTATtaatg ttctgTGTGGTAAAATTTAGTGAGAtgatttaaggaggaggagcatttatggaagaaa t" /listShort="S627, ynaB, ynaC, ynaD" /GFF_Attribute="listLong" CDS 1881536..1881970 /gene="ynaB" /locus_tag="BSU_17500" /old_locus_tag="BSU17500" /function="17.2: Prophage functions" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; defective phage region" /protein_id="NP_389632.2" /db_xref="EnsemblGenomes-Gn:BSU17500" /db_xref="EnsemblGenomes-Tr:CAB13634" /db_xref="InterPro:IPR018958" /db_xref="SubtiList:BG12254" /db_xref="UniProtKB/Swiss-Prot:P94480" /translation="MEDATFHFKDPASPQEISDIEQKLGVTFPNDYKEFLLQHNGMEM FDGIEILSLEGIIEYNEVQDFPEGYVLIGYHFDGRYVIDTNKSKNGLGYMLYLDSIDD IEDAINLDSNFEIWFDMLVSLNGTKYWEVNPNLQEYYKLVSE*" gene 1881536..1881970 /gene="ynaB" /locus_tag="BSU_17500" /old_locus_tag="BSU17500" CDS 1882040..1882831 /gene="ynaC" /locus_tag="BSU_17510" /old_locus_tag="BSU17510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; defective phage region" /protein_id="NP_389633.1" /db_xref="EnsemblGenomes-Gn:BSU17510" /db_xref="EnsemblGenomes-Tr:CAB13635" /db_xref="SubtiList:BG12255" /db_xref="UniProtKB/Swiss-Prot:P94481" /translation="MTIYEQIKDALKNKINELVSPQEVKKTLQEKYGTNPDSIILSDY CYNRYNKGISFNKHLFEYMNRSSYKYLGENSLYTGLIFRKSKGEDKEVIVGEWVNGVK SLREASVTNNQINDQAEIISKEQLVNLYNEYNQILRYEMNVLNCKPTELRHLIGRIGE FICAIQTNGTLARQTNQHGFDVVSDGRRISVKTTAQSSGFISINKNTFYDFDDFFVVQ YVNDDFKVIFFGSKEEVQKISRIYGSQYEVEISLLKKLNKEYQLN*" gene 1882040..1882831 /gene="ynaC" /locus_tag="BSU_17510" /old_locus_tag="BSU17510" promotor_-10 complement(1882148..1882167) /Source="Nicolas_upshift_promotors" /id="U1398" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.702297702297702" /psig="0.988011988011988" /xcortree=382 /SigmaFactorBS="gaggtgcttattaaaagaaatccccttattaTACcggttata acaataaTCTGATAAAATAATGCTATCcggattagttccgtatttttcttgaagggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1882156) /Source="Nicolas_upshifts" /id="U1398" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.702297702297702" /psig="0.988011988011988" /xcortree=382 /SigmaFactorBS="gaggtgcttattaaaagaaatccccttattaTACcggttata acaataaTCTGATAAAATAATGCTATCcggattagttccgtatttttcttgaagggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1882183..1882185) /Source="Nicolas_upshift_promotors" /id="U1398" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.702297702297702" /psig="0.988011988011988" /xcortree=382 /SigmaFactorBS="gaggtgcttattaaaagaaatccccttattaTACcggttata acaataaTCTGATAAAATAATGCTATCcggattagttccgtatttttcttgaagggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1882827 /Source="Nicolas_upshifts" /id="D948" /incds=0 /nref=10 /ntot=182 /MaxReadThrough="4.47202" /MaxDrop="6.29359" /score="3.60743536" /energy="-14.4" /TU="U1397" /idTUdmin="U1397" /TUdmin="-836" /isTUend="FALSE" downshifts 1882893 /Source="Nicolas_upshifts" /id="D949" /incds=0 /nref=1 /ntot=65 /MaxReadThrough="3.36892" /MaxDrop="4.40772" /score="3.60743536" /energy="-14.4" /TU="U1397" /idTUdmin="U1397" /TUdmin="-770" /isTUend="FALSE" promotor_-35 1883104..1883112 /Source="Nicolas_upshift_promotors" /id="U1399" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.628371628371628" /psig="0.628371628371628" /xcortree=3199 /SigmaFactorBS="gcaatattgttgaataagaatagttttaaAGAGGTTATtgtt gtcttcaTATTGAAATAAAGATTAAGtatattagaggggagttgctttaatgcacata a" /listShort="ynaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1883124..1883142 /Source="Nicolas_upshift_promotors" /id="U1399" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.628371628371628" /psig="0.628371628371628" /xcortree=3199 /SigmaFactorBS="gcaatattgttgaataagaatagttttaaAGAGGTTATtgtt gtcttcaTATTGAAATAAAGATTAAGtatattagaggggagttgctttaatgcacata a" /listShort="ynaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1883135 /Source="Nicolas_upshifts" /id="U1399" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.628371628371628" /psig="0.628371628371628" /xcortree=3199 /SigmaFactorBS="gcaatattgttgaataagaatagttttaaAGAGGTTATtgtt gtcttcaTATTGAAATAAAGATTAAGtatattagaggggagttgctttaatgcacata a" /listShort="ynaD" /GFF_Attribute="listLong" CDS 1883166..1883678 /gene="ynaD" /locus_tag="BSU_17520" /old_locus_tag="BSU17520" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase; putative phage region" /protein_id="NP_389634.1" /db_xref="EnsemblGenomes-Gn:BSU17520" /db_xref="EnsemblGenomes-Tr:CAB13636" /db_xref="GOA:P94482" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12256" /db_xref="UniProtKB/Swiss-Prot:P94482" /translation="MHITTKRLLIREFEFKDWQAVYEYTSDSNVMKYIPEGVFTEEDA KAFVNKNKGDNAEKFPVILRDEDCLIGHIVFYKYFGEHTYEIGWVFNPNYQNKGYASE AAQAILEYGFKEMNLHRIIATCQPENIPSYRVMKKIGMRREGFFKKCIPKGNEWWDEY YYAILEEEWN*" gene 1883166..1883678 /gene="ynaD" /locus_tag="BSU_17520" /old_locus_tag="BSU17520" promotor_-35 1884125..1884131 /Source="Nicolas_upshift_promotors" /id="U1400" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.665334665334665" /psig="0.994005994005994" /xcortree=3213 /SigmaFactorBS="aaagtgaacctgccacagatgttcattatcttttagggggtt ccaaaaagaccgtattccTATCGATcgctcagagtgaaAATGGTATACTAAAGTTACA a" /listShort="S628, ynaE, S629, ynaF, ynaG, ynzI, S630, ynaI, S631" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1884125 /Source="Nicolas_upshifts" /id="U1400" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.665334665334665" /psig="0.994005994005994" /xcortree=3213 /SigmaFactorBS="aaagtgaacctgccacagatgttcattatcttttagggggtt ccaaaaagaccgtattccTATCGATcgctcagagtgaaAATGGTATACTAAAGTTACA a" /listShort="S628, ynaE, S629, ynaF, ynaG, ynzI, S630, ynaI, S631" /GFF_Attribute="listLong" promotor_-35 1884127..1884131 /Source="Nicolas_upshift_promotors" /id="U1401" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=3221 /SigmaFactorBS="aaaaagaccgtattcctaTCGATcgctcagagtgaaAATGGT ATACTAAAGTTACAatcacaggaaggaattacaatttttttagatctacataaaatca t" /listShort="S628, ynaE, S629, ynaF, ynaG, ynzI, S630, ynaI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1884145..1884164 /Source="Nicolas_upshift_promotors" /id="U1400" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.665334665334665" /psig="0.994005994005994" /xcortree=3213 /SigmaFactorBS="aaagtgaacctgccacagatgttcattatcttttagggggtt ccaaaaagaccgtattccTATCGATcgctcagagtgaaAATGGTATACTAAAGTTACA a" /listShort="S628, ynaE, S629, ynaF, ynaG, ynzI, S630, ynaI, S631" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1884145..1884164 /Source="Nicolas_upshift_promotors" /id="U1401" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=3221 /SigmaFactorBS="aaaaagaccgtattcctaTCGATcgctcagagtgaaAATGGT ATACTAAAGTTACAatcacaggaaggaattacaatttttttagatctacataaaatca t" /listShort="S628, ynaE, S629, ynaF, ynaG, ynzI, S630, ynaI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1884169..1884237 /Source="Nicolas_S_feature" /locus_tag="new_1884169_1884237" /HighExp="T1.30H, M9-stat, Lbtran, M0t90, T0.30H, T1.0H, T2.30H, Lbstat, T3.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S628" upshifts 1884169 /Source="Nicolas_upshifts" /id="U1401" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=3221 /SigmaFactorBS="aaaaagaccgtattcctaTCGATcgctcagagtgaaAATGGT ATACTAAAGTTACAatcacaggaaggaattacaatttttttagatctacataaaatca t" /listShort="S628, ynaE, S629, ynaF, ynaG, ynzI, S630, ynaI" /GFF_Attribute="listLong" CDS 1884238..1884879 /gene="ynaE" /locus_tag="BSU_17530" /old_locus_tag="BSU17530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389635.1" /db_xref="EnsemblGenomes-Gn:BSU17530" /db_xref="EnsemblGenomes-Tr:CAB13637" /db_xref="InterPro:IPR024976" /db_xref="SubtiList:BG12257" /db_xref="UniProtKB/Swiss-Prot:P94483" /translation="MNLIGYIEERFQNLELIPSIYNQWGTGIHFCLGENIYQLKANEE LNLKMFRIVYEQTSIIFNELFEQNDDIFLVTNMYKHKKKEKCIRKLKVYQPFLKCKNH LNQIMVKTYPYPFEINKAEEYEMQQFSLLCKPRDLRVTELLKAASNEDFPQKPKFGGY SIDYPDVFFVNITKDIIFFIYDDRGCEVIAHDFKRIRPLYEKYHDWVEEYKCM*" gene 1884238..1884879 /gene="ynaE" /locus_tag="BSU_17530" /old_locus_tag="BSU17530" S_feature 1884880..1884967 /Source="Nicolas_S_feature" /locus_tag="new_1884880_1884967" /HighExp="M0t90, Lbtran, Lbstat, T1.30H, S2, T1.0H, T0.30H, MG 150, M9-stat, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S629" CDS 1884968..1885321 /gene="ynaF" /locus_tag="BSU_17540" /old_locus_tag="BSU17540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; defective phage region" /protein_id="NP_389636.1" /db_xref="EnsemblGenomes-Gn:BSU17540" /db_xref="EnsemblGenomes-Tr:CAB13638" /db_xref="SubtiList:BG12258" /db_xref="UniProtKB/Swiss-Prot:P94484" /translation="MVLCDDERSAFLLVLDERLVDFDSQGGNHISVYLVTHFELSDQS YKDVLSFNDDLLGMEHNCSYAMDILSVKEELDFDFPFNMLAIKSYVQELIKMLGIDIT LPEMKERDFDKLSQN*" gene 1884968..1885321 /gene="ynaF" /locus_tag="BSU_17540" /old_locus_tag="BSU17540" CDS 1885365..1885640 /gene="ynaG" /locus_tag="BSU_17550" /old_locus_tag="BSU17550" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; defective phage region" /protein_id="NP_389637.1" /db_xref="EnsemblGenomes-Gn:BSU17550" /db_xref="EnsemblGenomes-Tr:CAB13639" /db_xref="GOA:P94485" /db_xref="SubtiList:BG12259" /db_xref="UniProtKB/Swiss-Prot:P94485" /translation="MNVKKAAAVFSITIPIISAILIINFFTGFMSIPWQGMPVFFPLL LSPIGIILAFVSIKTNKRCAVYGIVLNAIMFPFPFFWFIGGALLFGV*" gene 1885365..1885640 /gene="ynaG" /locus_tag="BSU_17550" /old_locus_tag="BSU17550" downshifts complement(1885741) /Source="Nicolas_upshifts" /id="D950" /incds=0 /nref=2 /ntot=57 /MaxReadThrough="1.74772" /MaxDrop="3.30031" /score="-7.48025946" /energy="-14.4" /TU="NA" /idTUdmin="U1402" /TUdmin=308 /isTUend="FALSE" CDS 1885753..1885917 /gene="ynzI" /locus_tag="BSU_17559" /old_locus_tag="BSU17559" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; defective phage region" /protein_id="YP_003097730.1" /db_xref="EnsemblGenomes-Gn:BSU17559" /db_xref="EnsemblGenomes-Tr:CAX52623" /db_xref="GOA:C0H415" /db_xref="UniProtKB/Swiss-Prot:C0H415" /translation="MDRKKDEIQRKYREQMREKKEREKEDGSSHTFEIVVVLAIIILM FFFNSVFKAF*" gene 1885753..1885917 /gene="ynzI" /locus_tag="BSU_17559" /old_locus_tag="BSU17559" S_feature 1885918..1886056 /Source="Nicolas_S_feature" /locus_tag="new_1885918_1886056" /HighExp="M0t90, Lbstat, S1, Lbtran, S2, M40t90, T1.30H, Glu, T1.0H, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S630" CDS 1886057..1886527 /gene="ynaI" /locus_tag="BSU_17560" /old_locus_tag="BSU17560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; defective phage region" /protein_id="NP_389638.3" /db_xref="EnsemblGenomes-Gn:BSU17560" /db_xref="EnsemblGenomes-Tr:CAB13640" /db_xref="SubtiList:BG12261" /db_xref="UniProtKB/Swiss-Prot:P94487" /translation="MKLYNEFINIAKTFNKELDIIPLLYGSLGLEKVTGLDFSPEDID LLIPLIFLEEKWEKLKKVMELHGYKMVDLHEHEFKKTNTKIGISYIEDLKPFADVDYN NLEIFEDGGAKYHLLTIDDYLKIYKKSLLDGYRRRKKNHKDQSKINILNKLIRN*" gene 1886057..1886527 /gene="ynaI" /locus_tag="BSU_17560" /old_locus_tag="BSU17560" S_feature 1886528..1887351 /Source="Nicolas_S_feature" /locus_tag="new_1886528_1887351" /HighExp="Lbstat, M0t90, S8, C30, Pyr, Lbtran, M40t90, S1, M/G, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S631" promotor_-10 complement(1886691..1886709) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1886709) /Source="Nicolas_upshifts" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1886725..1886730) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1887352..1888743 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16684115, 16850406, 17183216, 20406496; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+-xyloside symporter" /protein_id="NP_389639.2" /db_xref="EnsemblGenomes-Gn:BSU17570" /db_xref="EnsemblGenomes-Tr:CAB13641" /db_xref="GOA:P94488" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12262" /db_xref="UniProtKB/Swiss-Prot:P94488" /translation="MLSENVKKISMVEKVGYASGDFACNLIYATVSTYLLFFYTDVFG LSAAAAGTMFLVVRIIDALADPFIGTIVDRTNSRFGRFRPYLLFGAFPFVILAILCFT TPDFSDMGKLIYAYITYVGLSLTYTTINVPYGALTSAMTRNNQEVVSITSVRMLFANL GGLVVAFFVPLLAAYLSDTSGNESLGWQLTMGILGMIGGCLLIFCFKSTKERVTLQKS EEKIKFTDIFEQFRVNRPLVVLSIFFIIIFGVNSISNSVGIYYVTYNLEREDLVKWYG LIGSLPALVILPFIPRLHQFLGKKKLLNYALLLNIIGLLALLFVPPSNVYLILVCRLI AAAGSLTAGGYMWALIPETIEYGEYRTGKRMGGLIYAIIGFFFKFGMALGGVVPGLVL DKFGYVANQAQTPAALMGILITTTIIPVFLLVLALIDINFYNLDEKKYKNMVRELENR DKVYLDHIDDFKA*" gene 1887352..1888743 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" CDS 1888774..1890375 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" /EC_number="3.2.1.37" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2440680, 6413490, 7816035, 9286998, 9973552, 16684115, 28066362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylan beta-1,4-xylosidase" /protein_id="NP_389640.2" /db_xref="EnsemblGenomes-Gn:BSU17580" /db_xref="EnsemblGenomes-Tr:CAB13642" /db_xref="GOA:P94489" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="PDB:1YIF" /db_xref="SubtiList:BG11987" /db_xref="UniProtKB/Swiss-Prot:P94489" /translation="MKITNPVLKGFNPDPSICRAGEDYYIAVSTFEWFPGVQIHHSKD LVNWHLVAHPLQRVSQLDMKGNPNSGGVWAPCLSYSDGKFWLIYTDVKVVDGAWKDCH NYLVTCETINGDWSEPIKLNSSGFDASLFHDTDGKKYLLNMLWDHRIDRHSFGGIVIQ EYSDKEQKLIGKPKVIFEGTDRKLTEAPHLYHIGNYYYLLTAEGGTRYEHAATIARSA NIEGPYEVHPDNPILTSWHDPGNPLQKCGHASIVQTHTDEWYLAHLTGRPIHPDDDSI FQQRGYCPLGRETAIQKLYWKDEWPYVVGGKEGSLEVDAPSIPETIFEATYPEVDEFE DSTLNINFQTLRIPFTNELGSLTQAPNHLRLFGHESLTSTFTQAFVARRWQSLHFEAE TAVEFYPENFQQAAGLVNYYNTENWTALQVTHDEELGRILELTICDNFSFSQPLNNKI VIPREVKYVYLRVNIEKDKYYYFYSFNKEDWHKIDIALESKKLSDDYIRGGGFFTGAF VGMQCQDTSGNHIPADFRYFRYKEK*" gene 1888774..1890375 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" S_feature complement(1888890..1889195) /Source="Nicolas_S_feature" /locus_tag="new_1888890_1889195_c" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, S4, B36, BC" /AntisenseName="xynB" /AntisenseCor="6.2527836498644102E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S632" promotor_-10 complement(1889190..1889209) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1889195) /Source="Nicolas_upshifts" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" promotor_-35 complement(1889223..1889231) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1890373 /Source="Nicolas_upshifts" /id="D951" /incds=0 /nref=2 /ntot=53 /MaxReadThrough="1.32947" /MaxDrop="3.8449" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1400" /TUdmin=3190 /isTUend="FALSE" CDS complement(1890512..1891666) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1588910, 1719948, 2544559, 7559331; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389641.3" /db_xref="EnsemblGenomes-Gn:BSU17590" /db_xref="EnsemblGenomes-Tr:CAB13643" /db_xref="GOA:P94490" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11986" /db_xref="UniProtKB/Swiss-Prot:P94490" /translation="MDIADQTFVKKVNQKLLLKEILKNSPISRAKLSEMTGLNKSTVS SQVNTLMKESMVFEIGQGQSSGGRRPVMLVFNKKAGYSVGIDVGVDYINGILTDLEGT IVLDQYRHLESNSPEITKDILIDMIHHFITQMPQSPYGLIGIGICVPGLIDKDQKIVF TPNSNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIG IGVIINNHLYRGVSGFSGEMGHMTIDFNGPKCSCGNRGCWELYASEKALLKSLQTKEK KLSYQDIINLAHLNDIGTLNALQNFGFYLGIGLTNILNTFNPQAVILRNSIIESHPMV LNSMRSEVSSRVYSQLGNSYELLPSSLGQNAPALGMSSIVIDHFLDMITM*" gene complement(1890512..1891666) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" downshifts complement(1890515) /Source="Nicolas_upshifts" /id="D952" /incds=0 /nref=9 /ntot=198 /MaxReadThrough="2.56326" /MaxDrop="4.09398" /score="19.297583" /energy="-7.4" /TU="NA" /idTUdmin="U1405" /TUdmin=0 /isTUend="TRUE" S_feature complement(1891565..1891743) /Source="Nicolas_S_feature" /locus_tag="new_1891565_1891743_c" /HighExp="dia15, Etha, dia5, dia0, Cold, LBGstat, Lbexp, M0t45, Diami, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S633" promotor_-35 1891711..1891717 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1891726..1891745) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1891727..1891743 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1891737 /Source="Nicolas_upshifts" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(1891743) /Source="Nicolas_upshifts" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" promotor_-35 complement(1891760..1891763) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1891770..1891777 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1891792..1891811 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1891803..1891907 /Source="Nicolas_S_feature" /locus_tag="new_1891803_1891907" /HighExp="dia15, dia0, Lbexp, dia5, B60, Sw, G150, LPhT, Mt0, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S634" upshifts 1891804 /Source="Nicolas_upshifts" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" CDS 1891908..1893245 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" /EC_number="5.3.1.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7663444, 8132469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7663444, 8132469; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylose isomerase" /protein_id="NP_389642.2" /db_xref="EnsemblGenomes-Gn:BSU17600" /db_xref="EnsemblGenomes-Tr:CAB13644" /db_xref="GOA:P0CI80" /db_xref="InterPro:IPR001998" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR013452" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG10806" /db_xref="UniProtKB/Swiss-Prot:P0CI80" /translation="MAQSHSSSINYFGSANKVVYEGKDSTNPLAFKYYNPQEVIGGKT LKEHLRFSIAYWHTFTADGTDVFGAATMQRPWDHYKGMDLAKMRVEAAFEMFEKLDAP FFAFHDRDIAPEGSTLKETNQNLDMIMGMIKDYMRNSGVKLLWNTANMFTNPRFVHGA ATSCNADVFAYAAAQVKKGLETAKELGAENYVFWGGREGYETLLNTDLKFELDNLARF MHMAVDYAKEIGYTGQFLIEPKPKEPTTHQYDTDAATTIAFLKQYGLDNHFKLNLEAN HATLAGHTFEHELRMARVHGLLGSVDANQGHPLLGWDTDEFPTDLYSTTLAMYEILQN GGLGSGGLNFDAKVRRSSFEPDDLIYAHIAGMDAFARGLKVAHKLIEDRVFEDVIQHR YRSFTEGIGLEIIEGRANFHTLEQYALNHKSIKNESGRQEKLKAILNQYILEV*" gene 1891908..1893245 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" S_feature 1893246..1893320 /Source="Nicolas_S_feature" /locus_tag="new_1893246_1893320" /HighExp="dia0, dia15, Sw, Lbexp, dia5, B60, Mt0, M0t45, G150, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S635" downshifts 1893277 /Source="Nicolas_upshifts" /id="D953" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="4.89699" /MaxDrop="3.40404" /score="13.0570501" /energy="-10.2" /TU="U1406" /idTUdmin="U1406" /TUdmin="-1892" /isTUend="FALSE" CDS 1893396..1894895 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" /EC_number="2.7.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1660563, 8866023, 27467131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylulose kinase" /protein_id="NP_389643.1" /db_xref="EnsemblGenomes-Gn:BSU17610" /db_xref="EnsemblGenomes-Tr:CAB13645" /db_xref="GOA:P39211" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006000" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10807" /db_xref="UniProtKB/Swiss-Prot:P39211" /translation="MKYVIGIDLGTSAVKTILVNQNGKVCAETSKRYPLIQEKAGYSE QNPEDWVQQTIEALAELVSISNVQAKDIDGISYSGQMHGLVLLDQDRQVLRNAILWND TRTTPQCIRMTEKFGDHLLDITKNRVLEGFTLPKMLWVKEHEPELFKKTAVFLLPKDY VRFRMTGVIHTEYSDAAGTLLLHITRKEWSNDICNQIGISADICPPLVESHDCVGSLL PHVAAKTGLLEKTKVYAGGADNACGAIGAGILSSGKTLCSIGTSGVILSYEEEKERDF KGKVHFFNHGKKDSFYTMGVTLAAGYSLDWFKRTFAPNESFEQLLQGVEAIPIGANGL LYTPYLVGERTPHADSSIRGSLIGMDGAHNRKHFLRAIMEGITFSLHESIELFREAGK SVHTVVSIGGGAKNDTWLQMQADIFNTRVIKLENEQGPAMGAAMLAAFGSGWFESLEE CAEQFIREAAAFYPKAQNVQKYKTLFDLYKNIYTHTKDLNTALKSFRKN*" gene 1893396..1894895 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" S_feature 1894896..1895211 /Source="Nicolas_S_feature" /locus_tag="new_1894896_1895211" /HighExp="dia0, dia15, Lbexp, dia5, Mt0, M0t45, G150, Etha, Diami, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.51323200000000002" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S636" downshifts 1895169 /Source="Nicolas_upshifts" /id="D954" /incds=0 /nref=60 /ntot=197 /MaxReadThrough="0.61776" /MaxDrop="5.13425" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1406" /TUdmin=0 /isTUend="TRUE" CDS complement(1895378..1896013) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11584000" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11584000; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA nuclease, lipoprotein (phage origin)" /protein_id="NP_389644.1" /db_xref="EnsemblGenomes-Gn:BSU17620" /db_xref="EnsemblGenomes-Tr:CAB13646" /db_xref="GOA:P94492" /db_xref="InterPro:IPR002071" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR035437" /db_xref="SubtiList:BG12265" /db_xref="UniProtKB/Swiss-Prot:P94492" /translation="MKKILISMIAIVLSITLAACGSNHAAKNHSDSNGTEQVSQDTHS NEYNQTEQKAGTPHSKNQKKLVNVTLDRAIDGDTIKVIYNGKKDTVRYLLVDTPETKK PNSCVQPYGEDASKRNKELVNSGKLQLEFDKGDRRDKYGRLLAYVYVDGKSVQETLLK EGLARVAYVYEPNTKYIDQFRLDEQEAKSDKLSIWSKSGYVTNRGFNGCVK*" gene complement(1895378..1896013) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" promotor_-10 complement(1896050..1896069) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1896059) /Source="Nicolas_upshifts" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" promotor_-35 complement(1896084..1896091) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1896201..1896208 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1896223..1896242 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1896225..1896423 /Source="Nicolas_S_feature" /locus_tag="new_1896225_1896423" /HighExp="T0.30H, Lbtran, T1.0H, M9-stat, M0t90, T1.30H, M40t90, T2.0H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S637" upshifts 1896225 /Source="Nicolas_upshifts" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" CDS 1896424..1897839 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22900538, 23569278; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar transporter" /protein_id="NP_389645.2" /db_xref="EnsemblGenomes-Gn:BSU17630" /db_xref="EnsemblGenomes-Tr:CAB13647" /db_xref="GOA:P94493" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12266" /db_xref="UniProtKB/Swiss-Prot:P94493" /translation="MDMNEHRNRRLKLIMISATFGGLLFGYDTGVINGALPFMARPDQ LDLTPVTEGLVTSILLLGAAFGALLCGRLADRYGRRKMILNLSFLFFLASLGTALAPN VFIMAVFRFLLGLAVGGASAMVPAFLAEMAPHEKRGRMVTQNELMIVGGQFLAYVFNA ILGVTMANTGHVWRYMLVICAVPAIMLFASMLKVPESPRWLISKGKNSEALRVLKQIR EDKRAEAECREIQEAVEKDTALEKASLKDFSTPWLRRLLWIGIGVAIVNQITGVNSIM YYGTQILKESGFGTKAALIANIGNGLISVIAVIFGIWLVGKVRRRPILLIGLAGTTTA LLLIAIFSIVLDGSMALPYVVLSLTVLFLAFMQGCVGPVTWLVIAEIFPQRLRGLGSG ISVFFLWILNFVIGFAFPILLSSVGLSFTFFIFVALGVLAIGFVYKFMPETKGRTLEE LEEHFRSRHDHNTPEQSVIEV*" gene 1896424..1897839 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" downshifts 1897829 /Source="Nicolas_upshifts" /id="D955" /incds=0 /nref=13 /ntot=69 /MaxReadThrough="0.90595" /MaxDrop="4.35189" /score="15.579587" /energy="-8.6" /TU="NA" /idTUdmin="U1408" /TUdmin="-2" /isTUend="TRUE" downshifts complement(1897932) /Source="Nicolas_upshifts" /id="D956" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="1.08869" /MaxDrop="5.39832" /score="24.3759796" /energy="-9.3" /TU="NA" /idTUdmin="U1409" /TUdmin="-3" /isTUend="TRUE" CDS complement(1897941..1899125) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" /EC_number="5.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10348844, 18399999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10348844, 18399999; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanine racemase (minor activity)" /protein_id="NP_389646.1" /db_xref="EnsemblGenomes-Gn:BSU17640" /db_xref="EnsemblGenomes-Tr:CAB13648" /db_xref="GOA:P94494" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="PDB:5IRP" /db_xref="SubtiList:BG12267" /db_xref="UniProtKB/Swiss-Prot:P94494" /translation="MIKLCREVWIEVNLDAVKKNLRAIRRHIPHKSKIMAVVKANGYG HGSIEVARHALEHGASELAVASVEEGIVLRKAGITAPILVLGFTSLSCVKKSAAWNIT LSAFQVDWMKEANEILEKEASANRLAIHINVDTGMGRLGVRTKEELLEVVKALKASKF LRWTGIFTHFSTADEPDTTLTKLQHEKFISFLSFLKKQGIELPTVHMCNTAAAIAFPE FSADMIRLGIGLYGLYPSAYIKQLNLVKLEPALSLKARIAYVKTMRTEPRTVSYGATY IAEPNEVIATLPIGYADGYSRALSNRGFVLHRGKRVPVAGRVTMDMIMVSLGENGEGK QGDEVVIYGKQKGAEISVDEVAEMLNTINYEVVSTLSRRIPRFYIRDGEIFKVSTPVL YV*" gene complement(1897941..1899125) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" S_feature complement(1899126..1899205) /Source="Nicolas_S_feature" /locus_tag="new_1899126_1899205_c" /HighExp="S4, S5, S3, S6, S7, B36, BT, S8, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.908" /TUlongSig="NA" /TUlongPSig="NA" /label="S638" promotor_-10 complement(1899198..1899216) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1899209) /Source="Nicolas_upshifts" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" promotor_-35 complement(1899232..1899237) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1899517..1899524 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1899539..1899558 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1899547 /Source="Nicolas_upshifts" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" CDS 1899589..1900050 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative prophage protein" /protein_id="NP_389648.2" /db_xref="EnsemblGenomes-Gn:BSU17650" /db_xref="EnsemblGenomes-Tr:CAB13649" /db_xref="InterPro:IPR020216" /db_xref="SubtiList:BG12268" /db_xref="UniProtKB/Swiss-Prot:P94495" /translation="MNRGVSFQIPNEYGNFLWRILQPVEIANYRWQTSGESYFVVEGE LDDEELFHDYEIVEGAVFEQQLKTNQYYTIFVELKAFPYGKMVNQVNTYEEFADSDCE LVLLIADNSYVSIYCKNKNIIEKLYFNALQHDFEDVQFITDENDTRTSLTV*" gene 1899589..1900050 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" CDS 1900080..1900514 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" /EC_number="3.6.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11375514, 15939294, 16908222, 17169987, 21358047, 23897460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11375514, 15939294, 16908222, 17169987, 21358047, 23897460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="deoxyuridine 5'-triphosphate pyrophosphatase (phage origin)" /protein_id="NP_389649.1" /db_xref="EnsemblGenomes-Gn:BSU17660" /db_xref="EnsemblGenomes-Tr:CAB13650" /db_xref="GOA:O31801" /db_xref="InterPro:IPR029054" /db_xref="InterPro:IPR033704" /db_xref="InterPro:IPR036157" /db_xref="PDB:2XCD" /db_xref="PDB:2XCE" /db_xref="PDB:4AOO" /db_xref="PDB:4AOZ" /db_xref="PDB:4APZ" /db_xref="PDB:4B0H" /db_xref="SubtiList:BG13437" /db_xref="UniProtKB/Swiss-Prot:O31801" /translation="MTMQIKIKYLDETQTRISKIEQGDWIDLRAAEDVTIKKDEFKLV PLGVAMELPEGYEAHVVPRSSTYKNFGVIQTNSMGVIDESYKGDNDFWFFPAYALRDT EIKKGDRICQFRIMKKMPAVELVEVEHLGNEDRGGLGSTGTK*" gene 1900080..1900514 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" S_feature complement(1900263..1900568) /Source="Nicolas_S_feature" /locus_tag="new_1900263_1900568_c" /HighExp="LoTm, S5, T5.0H, S8, T4.0H, S4, S7, T3.30H, Cold, T-4.40H" /AntisenseName="yncF" /AntisenseCor="-0.40042805081531202" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S639" downshifts 1900361 /Source="Nicolas_upshifts" /id="D957" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.18195" /MaxDrop="2.2821" /score="0.171090809" /energy="-9.3" /TU="U1410" /idTUdmin="U1408" /TUdmin=2530 /isTUend="FALSE" S_feature 1900515..1901611 /Source="Nicolas_S_feature" /locus_tag="new_1900515_1901611" /HighExp="S8, G150, G180, dia0, G135, UNK1, MG 15, Lbexp, Fru, S7" /AntisenseName="cotU" /AntisenseCor="-0.266961200384908" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S640" S_feature complement(1900570..1900855) /Source="Nicolas_S_feature" /locus_tag="new_1900570_1900855_c" /HighExp="LoTm, dia5, dia15, T3.30H, T3.0H, T-4.40H, T4.0H, T5.0H, T-3.40H, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25207000000000002" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S641" downshifts complement(1900613) /Source="Nicolas_upshifts" /id="D958" /incds=0 /nref=2 /ntot=95 /MaxReadThrough="4.29622" /MaxDrop="2.9464" /score="11.6697365" /energy="-9.7" /TU="U1411" /idTUdmin="U1411" /TUdmin="-308" /isTUend="FALSE" promotor_-10 complement(1900850..1900869) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1900855) /Source="Nicolas_upshifts" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" promotor_-35 complement(1900881..1900886) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1901117) /Source="Nicolas_upshifts" /id="D959" /incds=0 /nref=17 /ntot=130 /MaxReadThrough="2.07509" /MaxDrop="8.56023" /score="11.6697365" /energy="-9.7" /TU="NA" /idTUdmin="U1412" /TUdmin=1 /isTUend="TRUE" CDS complement(1901117..1901377) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12562816, 18065538, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 18065538, 20023017; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389650.1" /db_xref="EnsemblGenomes-Gn:BSU17670" /db_xref="EnsemblGenomes-Tr:CAB13651" /db_xref="GOA:O31802" /db_xref="SubtiList:BG13471" /db_xref="UniProtKB/Swiss-Prot:O31802" /translation="MGYYKKYKEEYYTWKKTYYKKYYDNDKKHYDCDKYYDHDKKHYD YDKKYDDHDKKYYDDHDYHYEKKYYDDDDHYYDFVESYKKHH*" gene complement(1901117..1901377) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" promotor_-10 complement(1901398..1901417) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1901408) /Source="Nicolas_upshifts" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" promotor_-35 complement(1901430..1901439) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1901612..1901737 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein (putative phage origin)" /db_xref="PSEUDO:CAX52624.1" /translation="MNVMVKIQELYDVIFHTAFEGFRVRHQKQTAKPARNRSYKE*" gene 1901612..1901737 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /pseudo S_feature 1901738..1901854 /Source="Nicolas_S_feature" /locus_tag="new_1901738_1901854" /HighExp="G180, G135, G150, dia0, UNK1, S8, Lbexp, C90, MG 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S642" CDS 1901781..1901945 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein from phage origin" /protein_id="YP_009513957.1" /translation="MKLERIYFKESPIAHGQMTIDIEVKYNALNQKKLLEDLMCLDNF QFGIHKHLTI*" gene 1901781..1901945 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" promotor_-35 1901829..1901838 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1901852..1901871 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1901856..1902166 /Source="Nicolas_S_feature" /locus_tag="new_1901856_1902166" /HighExp="S7, S6, S8, S5, BT, G/S, Pyr, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.585202" /TUshortSig="SigK, SigA" /TUshortPSig="0.935, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S643" upshifts 1901856 /Source="Nicolas_upshifts" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" promotor_-35 1902147..1902154 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1902168..1902187 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1902168 /Source="Nicolas_upshifts" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" CDS 1902219..1903058 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:416889, 418407, 9648749, 10091656, 10574451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 416889, 418407, 9648749, 10091656, 10574451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase A (phage origin)" /protein_id="NP_389651.1" /db_xref="EnsemblGenomes-Gn:BSU17680" /db_xref="EnsemblGenomes-Tr:CAB13652" /db_xref="GOA:P0CI79" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="PDB:1B02" /db_xref="PDB:1BKO" /db_xref="PDB:1BKP" /db_xref="PDB:1BSF" /db_xref="PDB:1BSP" /db_xref="SubtiList:BG11190" /db_xref="UniProtKB/Swiss-Prot:P0CI79" /translation="MTQFDKQYNSIIKDIINNGISDEEFDVRTKWDSDGTPAHTLSVI SKQMRFDNSEVPILTTKKVAWKTAIKELLWIWQLKSNDVNDLNMMGVHIWDQWKQEDG TIGHAYGFQLGKKNRSLNGEKVDQVDYLLHQLKNNPSSRRHITMLWNPDELDAMALTP CVYETQWYVKHGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNI GDCHVYTRHIDNLKIQMEREQFEAPELWINPEVKDFYDFTIDDFKLINYKHGDKLLFE VAV*" gene 1902219..1903058 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" promotor_-10 complement(1902241..1902260) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1902262) /Source="Nicolas_upshifts" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1902275..1902278) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1903018 /Source="Nicolas_upshifts" /id="D960" /incds=0 /nref=6 /ntot=143 /MaxReadThrough="4.34299" /MaxDrop="3.3234" /score="1.39203037" /energy="-7.7" /TU="U1410,U1414" /idTUdmin="U1413" /TUdmin="-4" /isTUend="TRUE" downshifts complement(1903164) /Source="Nicolas_upshifts" /id="D961" /incds=0 /nref=6 /ntot=150 /MaxReadThrough="3.28185" /MaxDrop="3.73135" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1417" /TUdmin="-286" /isTUend="FALSE" S_feature complement(1903165..1903471) /Source="Nicolas_S_feature" /locus_tag="new_1903165_1903471_c" /HighExp="LBGstat, Lbstat, LoTm, B60, LPhT, M9-stat, T1.30H, B36, nit, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99924299999999999" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S644" CDS complement(1903181..1903468) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513958.1" /translation="MEHTGHSSFLQLFCLNLTLIRVEIGMKYEKTSLFGMILVIVALL ISIYFMCNTNALIPAGYDLAIHGIVISRTVMIAFTLYLVSKLGYFLLNKKD*" gene complement(1903181..1903468) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" downshifts complement(1903208) /Source="Nicolas_upshifts" /id="D962" /incds=0 /nref=2 /ntot=85 /MaxReadThrough="3.82042" /MaxDrop="6.47995" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1418" /TUdmin=308 /isTUend="FALSE" promotor_-35 1903295..1903303 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1903317..1903336 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1903319 /Source="Nicolas_upshifts" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" S_feature 1903330..1903490 /Source="Nicolas_S_feature" /locus_tag="new_1903330_1903490" /HighExp="S8, S6, S7, BT, S5, S4, S3, Pyr, G/S, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S645" downshifts 1903462 /Source="Nicolas_upshifts" /id="D963" /incds=0 /nref=13 /ntot=53 /MaxReadThrough="1.26429" /MaxDrop="5.75919" /score="7.35184753" /energy="-11.1" /TU="NA" /idTUdmin="U1416" /TUdmin=0 /isTUend="TRUE" CDS complement(1903511..1904233) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved exported protein" /protein_id="NP_389652.2" /db_xref="EnsemblGenomes-Gn:BSU17690" /db_xref="EnsemblGenomes-Tr:CAB13653" /db_xref="GOA:O31803" /db_xref="InterPro:IPR029143" /db_xref="PDB:4HFS" /db_xref="SubtiList:BG13438" /db_xref="UniProtKB/Swiss-Prot:O31803" /translation="MVKKVLIAGAVGTAVLFGTLSSGIPGLPAADAQVAKAASELPNG IGGRVYLNSTGAVFTAKIVLPETVKNNDSVSTPYIYSGFRATSGTEADIGLQYSKQYN VWKPLMKVGSKNEETYIEGKDKFTYNKGFRPGSTVQMTIYKNLSGNTRMTLWGTNNDG YTGRIITEIQGTNIGTISKWKTLATAAVSYESQRDAIKATFSTSFNNITIDNKAVTPV VDTQDFAKVSVAGNNVTISVNK*" gene complement(1903511..1904233) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" downshifts complement(1903516) /Source="Nicolas_upshifts" /id="D964" /incds=0 /nref=31 /ntot=133 /MaxReadThrough="5.62856" /MaxDrop="4.3658" /score="0.425084384" /energy="-11.1" /TU="U1417" /idTUdmin="U1418" /TUdmin=0 /isTUend="TRUE" misc_feature complement(1904258..1904277) /Source="Nicolas_upshift_promotors" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1904266) /Source="Nicolas_upshifts" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" S_feature complement(1904268..1904392) /Source="Nicolas_S_feature" /locus_tag="new_1904268_1904392_c" /HighExp="H2O2, dia15, S8, G180, G150, Paraq, Oxctl, LBGstat, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S646" CDS complement(1904393..1904749) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function (phage origin)" /protein_id="YP_003097731.1" /db_xref="EnsemblGenomes-Gn:BSU17699" /db_xref="EnsemblGenomes-Tr:CAX52625" /db_xref="GOA:C0H417" /db_xref="InterPro:IPR025621" /db_xref="UniProtKB/Swiss-Prot:C0H417" /translation="MYRNIVFYLILLCLFISVVMKSFEVIRTIANVICFIFVLLYFKD EMKTYSRKALAILSICFLFLVGICAFIILQGQTLMKRHLFFTGLETIAGILLIIVSLS ICTFILRKISNRLKRM*" gene complement(1904393..1904749) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" promotor_-10 complement(1904773..1904792) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1904790) /Source="Nicolas_upshifts" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" promotor_-35 complement(1904808..1904812) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1904989) /Source="Nicolas_upshifts" /id="D965" /incds=0 /nref=58 /ntot=194 /MaxReadThrough="0.902090000000001" /MaxDrop="9.00312" /score="34.0680178" /energy="-10.8" /TU="NA" /idTUdmin="U1419" /TUdmin="-21" /isTUend="TRUE" CDS complement(1904995..1905195) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389653.2" /db_xref="EnsemblGenomes-Gn:BSU17700" /db_xref="EnsemblGenomes-Tr:CAB13654" /db_xref="GOA:P07790" /db_xref="SubtiList:BG10492" /db_xref="UniProtKB/Swiss-Prot:P07790" /translation="MGYYKKYKEEYYTVKKTYYKKYYEYDKKDYDCDYDKKYDDYDKK YYDHDKKDYDYVVEYKKHKKHY*" gene complement(1904995..1905195) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" downshifts 1905178 /Source="Nicolas_upshifts" /id="D966" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="1.37504" /MaxDrop="5.08099" /score="-4.2739983" /energy="-8" /TU="NA" /idTUdmin="U1416" /TUdmin=1716 /isTUend="FALSE" promotor_-10 complement(1905217..1905236) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1905229) /Source="Nicolas_upshifts" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" promotor_-35 complement(1905249..1905258) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1905370..1905558) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10974125, 11007775, 26239117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974125, 11007775, 26239117; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_389654.1" /db_xref="EnsemblGenomes-Gn:BSU17710" /db_xref="EnsemblGenomes-Tr:CAB13655" /db_xref="GOA:O31804" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG13464" /db_xref="UniProtKB/Swiss-Prot:O31804" /translation="MELSFTKILVILFVGFLVFGPDKLPALGRAAGKALSEFKQATSG LTQDIRKNDSENKEDKQM*" gene complement(1905370..1905558) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" downshifts complement(1905386) /Source="Nicolas_upshifts" /id="D967" /incds=0 /nref=213 /ntot=254 /MaxReadThrough="3.38696" /MaxDrop="6.07983" /score="8.58114058" /energy="-11" /TU="U1420,U1421" /idTUdmin="U1420" /TUdmin="-374" /isTUend="FALSE" misc_feature complement(1905527..1905534) /Source="Nicolas_upshift_promotors" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1905540) /Source="Nicolas_upshifts" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" promotor_-10 complement(1905587..1905606) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1905605) /Source="Nicolas_upshifts" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" promotor_-35 complement(1905621..1905628) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1905637..1905774 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513959.1" /translation="MNILKPAQRRIHKTAAAEYNVQCHLPKKQEAGWINYVALPEMIQ T*" gene 1905637..1905774 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" promotor_-35 1905668..1905673 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1905688..1905706 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1905706..1905808 /Source="Nicolas_S_feature" /locus_tag="new_1905706_1905808" /HighExp="S3, S4, LoTm, BT, B36, S5, S7, S6, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.35884500000000003" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S647" upshifts 1905706 /Source="Nicolas_upshifts" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" CDS 1905809..1906207 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein of unknown function" /protein_id="NP_389655.1" /db_xref="EnsemblGenomes-Gn:BSU17720" /db_xref="EnsemblGenomes-Tr:CAB13656" /db_xref="SubtiList:BG13439" /db_xref="UniProtKB/Swiss-Prot:O31805" /translation="MRFTKVVGFLSVLGLAAVFPLTAQAEKAGTAGAGEWDKLGTYTY TYSSPTVYSTGGDFRVCLSGSTPFSVSLHLYEDDPGDNPDDYVGANYFSPGECHTFGS IGKFVDGSNNKAEFFVTDYSGKSKTVTFYD*" gene 1905809..1906207 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" S_feature 1906208..1907012 /Source="Nicolas_S_feature" /locus_tag="new_1906208_1907012" /HighExp="LoTm, S3, BT, S4, B36, S6, S5, S7, S8, T5.0H" /AntisenseName="yndB" /AntisenseCor="-0.559713635360228" /AntisenseRegPval="-22.9" /CDS_PredictionProba="0.91098199999999996" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S648" CDS complement(1906272..1906706) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" /experiment="publication(s) with functional evidences, PMID:20818668, 28160315" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20818668, 28160315; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of stress-related ATPase (flavonoid-sensing)" /protein_id="NP_389656.1" /db_xref="EnsemblGenomes-Gn:BSU17730" /db_xref="EnsemblGenomes-Tr:CAB13657" /db_xref="GOA:O31806" /db_xref="InterPro:IPR013538" /db_xref="InterPro:IPR023393" /db_xref="PDB:2KEW" /db_xref="PDB:2KTE" /db_xref="SubtiList:BG13440" /db_xref="UniProtKB/Swiss-Prot:O31806" /translation="MAQNNENALPDITKSITLEAPIQKVWETVSTSEGIAKWFMPNDF QLKEGQEFHLQSPFGPSPCKVLAVQAPTELSFEWDTEGWVVTFQLEDLGEKTGFTLIH SGWKEPNEVIGKANEKSSVVRGKMDGGWTGIVNERLRKAVEE*" gene complement(1906272..1906706) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" downshifts complement(1906288) /Source="Nicolas_upshifts" /id="D968" /incds=0 /nref=213 /ntot=253 /MaxReadThrough="1.7995" /MaxDrop="6.63594" /score="29.1580701" /energy="-7" /TU="NA" /idTUdmin="U1423" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1906736..1906755) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1906752) /Source="Nicolas_upshifts" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" promotor_-35 complement(1906769..1906776) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1907013..1907201 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846" /codon_start=1 /transl_table=11 /product="conserved protein involved in spore germination" /protein_id="NP_389657.2" /db_xref="EnsemblGenomes-Gn:BSU17740" /db_xref="EnsemblGenomes-Tr:CAB13658" /db_xref="SubtiList:BG13465" /db_xref="UniProtKB/Swiss-Prot:O31807" /translation="MLGKIKAAIDNSPGKPARILVSEKAFQQLEEEMRFVYVSKPKTI MGIPVEVSDQAESFKLEF*" gene 1907013..1907201 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" S_feature 1907202..1907287 /Source="Nicolas_S_feature" /locus_tag="new_1907202_1907287" /HighExp="LoTm, BT, S4, S6, S3, S8, S7, B36, S5, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S649" downshifts 1907246 /Source="Nicolas_upshifts" /id="D969" /incds=0 /nref=7 /ntot=89 /MaxReadThrough="2.20002" /MaxDrop="4.21414" /score="19.5879917" /energy="-11.9" /TU="NA" /idTUdmin="U1422" /TUdmin=0 /isTUend="TRUE" promotor_-35 1907316..1907322 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1907334..1907493 /Source="Nicolas_S_feature" /locus_tag="new_1907334_1907493" /HighExp="S8, S4, S6, S7, S5, S3, BT, ferm, LoTm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.95681300000000002" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S650" upshifts 1907334 /Source="Nicolas_upshifts" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" promotor_-10 1907336..1907347 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1907494..1909056 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10762253, 27208128; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_389658.1" /db_xref="EnsemblGenomes-Gn:BSU17750" /db_xref="EnsemblGenomes-Tr:CAB13659" /db_xref="GOA:O31808" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG13441" /db_xref="UniProtKB/Swiss-Prot:O31808" /translation="MMRWRNNQYKTQKQHKSDYSTAEKQDQDVLTGNIGYDLEHVKRK IGHNGDVHFRELEITQLHVKAALIFVEGLSDQDLINKGLSVLVMNQPNQVSDEISQSG KGILTSKQIKNQIVSIGDVIDSEKISDIVLNVFMGSTALLIDGIPQAFLLGTVKKQNR SIEEPLSEALVRGPRTGFTEELSTNTALLRQQGKNDQLTLQRFEVGTRLKKDLIIAYM NDIADPKVVEEVRKRVRGIEIDHLPESGYVEQLIEDNYLSPFPQVQSTERPDRVISGL MEGRVAILLDGTPFALIVPVTFSMMLQSPEDYYERWFPSSLIRLLRFIAAMITLFAPA LYISFISFHPGLIPTKLAISISGTRQGVPFPSLIEALFMEVAIEILREAGLRLPKPIG PAIGIVGGLIIGEAAVQAGIVSPIMVIVVALTAISSFAIPHYSTGIALRMLRFGAMFC AAVFGLFGVIMYYLLLSSHVVKLKSFGVPYASPAVPYHLKDWKDFVIRMPLLVMKRRP KMMNTDNTKRVK*" gene 1907494..1909056 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" promotor_-10 complement(1907797..1907816) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1907806) /Source="Nicolas_upshifts" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1907831..1907838) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1909086..1910177 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane protein" /protein_id="NP_389659.1" /db_xref="EnsemblGenomes-Gn:BSU17760" /db_xref="EnsemblGenomes-Tr:CAB13660" /db_xref="GOA:O31809" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG13442" /db_xref="UniProtKB/Swiss-Prot:O31809" /translation="MFSPTSKITTAQATIIIINYMLAAGVLTLPRTVTEQTQSPDGWI SVLLGGVLAVIAGMIIAKLSQQYPKETFYEYSRHIVGKWLGHLISIVFITYFLALGAF EVRVMSEIVDFFLLEGTPSWAIIMTVLWIGLYSITQGLDPIARLFEMIFPITVIIFLT IALMSLGIFEINNLRPVLGDGIMPVLRGVKTTNLSFTCSEIMFILVAFMKKPKNAVKA VVIGTGVVTSFYMITMIMVIGALSVEGVVTRTWPGLDLMRSFEIPGLIFERFESFLLV IWIMQLFATFIITFYAASLGVSQVFKKKPLSCMFGLLPVIYILSCMPKNENDVFILGD TVSHIALYIFGALPILLLVISKWRKRGEK*" gene 1909086..1910177 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" CDS 1910167..1911381 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 27208128; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative spore germination lipoprotein" /protein_id="NP_389660.1" /db_xref="EnsemblGenomes-Gn:BSU17770" /db_xref="EnsemblGenomes-Tr:CAB13661" /db_xref="GOA:O31810" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG13443" /db_xref="UniProtKB/Swiss-Prot:O31810" /translation="MKSKLKRQLPAMVIVCLLMICVTGCWSSREIEDLGLTFAIAIDK GKETNTEKELKEEGGSYPKKDNITLTYQFVNEKAAGAGTSGGGGSGQGAQKAYINISE TGDSLQQIGSEVALRRDREVFSPHLKVVVMSEDVLHTFPIDEMLDQFFRDNEIRLSCL VLSAKGEARDALQLKENGEIPAFRLIGLGENEHKVSRILPPMTLAKLIGKLHSGSSFL LQNVVAANGAVKYSGAAVINGKSKKMIGTLNEYETEGITWIRGEGKGGVVKSHDKKSQ QTLAYDINKIKSRIQPIVKGKDISFHVDIESEGDLVENWNTKEALDTQFIDRLETTIE NEVKKIVGQVLKKIQHDYKADVAGFDESFRLTYPHLWKRVKNNWDDTFSKADITYSVN VTITHFGTVKTQ*" gene 1910167..1911381 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" promotor_-35 1911459..1911466 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1911481..1911500 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1911492 /Source="Nicolas_upshifts" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" CDS 1911528..1912334 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11737947, 22333191, 27435445" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389661.1" /db_xref="EnsemblGenomes-Gn:BSU17780" /db_xref="EnsemblGenomes-Tr:CAB13662" /db_xref="GOA:O31811" /db_xref="SubtiList:BG13444" /db_xref="UniProtKB/Swiss-Prot:O31811" /translation="MRQKPIYVEIEMKSDLDTLWEYTQNPSLHKEWDLRFSNITYLNS QPCEKQKFLYETRVGFGLKVSGTGETVGVFNKCSSERSSSLAFGSDHPLSLIRHGSGY WKYIQRENGKMTFLTQYQYKTAYGLLGRWIDRLLFRPLLGWATAWSFDALRLWVEQNK HPKRFIRSAIIYVFMCLFFSLFWFYQGFAGVKTSILTGTAEIGLAILWLLPLKRKWII HGVQACIFAGFACLGSEIFMWVLLSVFSAASGALSLQLPSARRTKRKRKK*" gene 1911528..1912334 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" S_feature complement(1912142..1913240) /Source="Nicolas_S_feature" /locus_tag="new_1912142_1913240_c" /HighExp="S8, S6, S7, S5, T0.30H, T2.0H, GM 150, BT, T1.30H, T-4.40H" /AntisenseName="yndH" /AntisenseCor="-0.58089150558713998" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S651" CDS 1912339..1912956 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389662.1" /db_xref="EnsemblGenomes-Gn:BSU17790" /db_xref="EnsemblGenomes-Tr:CAB13663" /db_xref="InterPro:IPR025311" /db_xref="SubtiList:BG13445" /db_xref="UniProtKB/Swiss-Prot:O31812" /translation="MSSIYEKSIINYHLLHPKLQKRYQLDGSHTFSGTGTMSEISGGS FLVRMLLKLGVFFRCFFSERGKDIPFTIQNRTCLLKSQHTGIEWNRTFFFKGKKRFFD ALMIYDEKENRILDFFGKPHLLLSVLTFEASLDGSLTITSGKQWLLICGKRIPLPKWL TGTSEVCETFDEKKNCFTIEVHVQNTILGTLFFYKGTFQEEERES*" gene 1912339..1912956 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" CDS 1912953..1914593 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618455, 15849754, 16850406, 28615734; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389663.1" /db_xref="EnsemblGenomes-Gn:BSU17800" /db_xref="EnsemblGenomes-Tr:CAB13664" /db_xref="GOA:O31813" /db_xref="InterPro:IPR025450" /db_xref="SubtiList:BG13446" /db_xref="UniProtKB/Swiss-Prot:O31813" /translation="MKRNGIVSALCFIGFLAAEAPDISVAEALVLLSILFFVPGIFPF VFRQSPVRAAQFMENGLIQCYPVAAFFAVLALVTEVGGFALIWWMYTVFNALYAILRL WETKIHRIEETSVLFGLIYLAGGGFWFFAYAAHLQIMQFGPLIILLTAVHFHYSAFLI PIFNGLLGRTIRKHRMLYSWITWVILLSPLLIALGITYSKTLDVIAVSIYMAAIYLHA FLVFTAAFRTKTGTFLIRLSSAVLMITIAFSMIYSFGVFRQEVTLTINQMIWIHGFVN AFGVILPALIGWRIEDAKPFDADSVKTFSRIYGKRKIGEEFLANIQAENNARYSGLVD DMGSLRSKDFSPEKLAPLILSFYEQTIEYNIKAKVTWSTWFRPLAIIYEWFSRRIGQI HLSTNPDWYRMYSKIKGVHSKKDGRERVRAWIRTNEKNETIFTALYSVYRSNGEGYMN ISLPLPFSSMTGILKPYHHQEKLVLTSRRRKSRAGDEGIYLQTRAGTCPLPLSETFLI EAVHDNKLTAVHHMWLFGIKFLTVHYSITHINQPIERT*" gene 1912953..1914593 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" promotor_-10 complement(1913227..1913246) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1913240) /Source="Nicolas_upshifts" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" promotor_-35 complement(1913260..1913268) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1914233..1914999) /Source="Nicolas_S_feature" /locus_tag="new_1914233_1914999_c" /HighExp="T2.0H, T1.30H, T2.30H, GM 150, T3.30H, T1.0H, C30, T3.0H, T4.0H, T0.30H" /AntisenseName="yndK" /AntisenseCor="-0.33555507319526101" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S652" CDS 1914630..1914995 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage/plasmid replication protein" /protein_id="NP_389664.1" /db_xref="EnsemblGenomes-Gn:BSU17810" /db_xref="EnsemblGenomes-Tr:CAB13665" /db_xref="GOA:O31814" /db_xref="SubtiList:BG13447" /db_xref="UniProtKB/Swiss-Prot:O31814" /translation="MNCFKILHRIKTGKEGFMVFYISLFLILWLAAGFAVGMKQVYVD QLFDKAVIERLEKEANDHGHADRMIKQRVLYIAAVTVSGFISVYYEMKTIPQRRNIRK IEKNIMKLNQAKKRRMKRK*" gene 1914630..1914995 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" downshifts 1914972 /Source="Nicolas_upshifts" /id="D970" /incds=0 /nref=166 /ntot=243 /MaxReadThrough="2.62352" /MaxDrop="5.68917" /score="15.340233" /energy="-10.4" /TU="NA" /idTUdmin="U1426" /TUdmin=2226 /isTUend="FALSE" misc_RNA complement(1914992..1915272) /gene="surA" /locus_tag="BSU_misc_RNA_72" /product="small untranslated RNA controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" gene complement(1914992..1915272) /gene="surA" /locus_tag="BSU_misc_RNA_72" S_feature complement(1915001..1915132) /Source="Nicolas_S_feature" /locus_tag="new_1915001_1915132_c" /HighExp="B60, T2.0H, T1.30H, T1.0H, T2.30H, M9-stat, LoTm, S5, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.443, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S653" downshifts complement(1915044) /Source="Nicolas_upshifts" /id="D971" /incds=0 /nref=21 /ntot=129 /MaxReadThrough="4.91485" /MaxDrop="4.94426" /score="14.7738511" /energy="-10.4" /TU="U1429,U1431" /idTUdmin="U1429" /TUdmin="-22" /isTUend="TRUE" promotor_-35 1915092..1915101 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1915114..1915123) /Source="Nicolas_upshift_promotors" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1915115..1915134 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1915120 /Source="Nicolas_upshifts" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" S_feature 1915122..1915220 /Source="Nicolas_S_feature" /locus_tag="new_1915122_1915220" /HighExp="S8, S6, S7, BT, S5, G/S, B36, C30, Pyr, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52117199999999997" /TUshortSig="SigK" /TUshortPSig="0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S654" upshifts complement(1915132) /Source="Nicolas_upshifts" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" S_feature complement(1915134..1915264) /Source="Nicolas_S_feature" /locus_tag="new_1915134_1915264_c" /HighExp="T2.0H, T1.30H, M9-stat, T2.30H, T1.0H, B60, LoTm, T4.0H, T3.30H, T0.30H" /AntisenseName="yndL" /AntisenseCor="0.22331158442510801" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S655" CDS 1915221..1915979 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" /EC_number="3.4.19.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26158264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26158264; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage gamma-polyglutamate hydrolase" /protein_id="NP_389665.1" /db_xref="EnsemblGenomes-Gn:BSU17820" /db_xref="EnsemblGenomes-Tr:CAB13666" /db_xref="GOA:O31815" /db_xref="InterPro:IPR008585" /db_xref="SubtiList:BG13448" /db_xref="UniProtKB/Swiss-Prot:O31815" /translation="MKPAKVSLLRRLLHSLKHVDCNIAKRFPSTIKIVKLLMIFMVFT PISSIYAEDVYQNFEELKNNEDPSDYGVVTKETGSPVLVLAIHGGGIEGGTSEVAREL SKEYSMYLFEGLKSAGNSVLHITSTHFDEPRALKMTGNHEYVISLHGYAEEDQQIEVG GTDRVRAADLVEKLQHAGFPAVLLNMDHPHAGVSPNNIANKSKTGLSIQIEMSTGFRK SLFGIFSLKSRAVTQNERFYEFTEVMFRFLKNSY*" gene 1915221..1915979 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" promotor_-35 1915247 /Source="Nicolas_upshift_promotors" /id="U1430" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.211788211788212" /xcortree=1323 /SigmaFactorBS="gttgatttggacttagaggcggagtagatgaaaccggccaaa gtatccctgctCcGccgtttgctccattccttgaagcatgttgattgtaacatagcca a" /listShort="yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1915249 /Source="Nicolas_upshift_promotors" /id="U1430" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.211788211788212" /xcortree=1323 /SigmaFactorBS="gttgatttggacttagaggcggagtagatgaaaccggccaaa gtatccctgctCcGccgtttgctccattccttgaagcatgttgattgtaacatagcca a" /listShort="yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1915254 /Source="Nicolas_upshifts" /id="U1430" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.211788211788212" /xcortree=1323 /SigmaFactorBS="gttgatttggacttagaggcggagtagatgaaaccggccaaa gtatccctgctCcGccgtttgctccattccttgaagcatgttgattgtaacatagcca a" /listShort="yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" promotor_-10 complement(1915270..1915289) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1915271) /Source="Nicolas_upshifts" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" promotor_-35 complement(1915304..1915311) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1915794..1916005) /Source="Nicolas_S_feature" /locus_tag="new_1915794_1916005_c" /HighExp="S8, S5, S7, S6, S4, ferm, nit, BT, Pyr, G/S" /AntisenseName="yndL" /AntisenseCor="0.82198535504067005" /AntisenseRegPval="-66.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.515" /TUlongSig="NA" /TUlongPSig="NA" /label="S656" downshifts 1915958 /Source="Nicolas_upshifts" /id="D972" /incds=0 /nref=3 /ntot=23 /MaxReadThrough="4.17889" /MaxDrop="5.0493" /score="15.340233" /energy="-10.4" /TU="U1428,U1430" /idTUdmin="U1428" /TUdmin="-1540" /isTUend="FALSE" S_feature 1916003..1916622 /Source="Nicolas_S_feature" /locus_tag="new_1916003_1916622" /HighExp="S8, S6, S7, S5, C30, BT, G135, LBGstat, GM 150, M/G" /AntisenseName="yndM" /AntisenseCor="0.75549671487088998" /AntisenseRegPval="-50.2" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S657" CDS complement(1916006..1916545) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389666.1" /db_xref="EnsemblGenomes-Gn:BSU17830" /db_xref="EnsemblGenomes-Tr:CAB13667" /db_xref="GOA:O31816" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG13449" /db_xref="UniProtKB/Swiss-Prot:O31816" /translation="MTIMNGFELHYLSFVYAQEFSSKNNNLGGQMKHIIALASKIAFT LALLYVILDRVYHASFLSVMFIALFLGFVSYLSGDMLVLPRTNNITASLADFGLSFVI LWVFVLTQTRNDFSPFGAALLSAACLTVFEYFFHRYLLKNVLDENFRNELSARDNTLQ YQTEAADELFPETKEKHKE*" gene complement(1916006..1916545) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" promotor_-10 complement(1916546..1916560) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1916552) /Source="Nicolas_upshifts" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" promotor_-35 complement(1916574..1916580) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1916600..1916609 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1916622..1916637 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1916624 /Source="Nicolas_upshifts" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" CDS 1916663..1917097 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" /EC_number="2.5.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11244082, 16399398, 19763274, 23256780" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244082, 16399398, 19763274, 23256780; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="magnesium-dependent bacillithiol-transferase" /protein_id="NP_389667.1" /db_xref="EnsemblGenomes-Gn:BSU17840" /db_xref="EnsemblGenomes-Tr:CAB13668" /db_xref="GOA:O31817" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR022858" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13450" /db_xref="UniProtKB/Swiss-Prot:O31817" /translation="MEIKGINHLLFSVSHLDTSIDFYQKVFGAKLLVKGRTTAYFDMN GIWLALNEEPDIPRNDIKLSYTHIAFTIEDHEFEEMSAKLKRLHVNILPGRERDERDR KSIYFTDPDGHKFEFHTGTLQDRLRYYKQEKTHMHFYDETAF*" gene 1916663..1917097 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" CDS 1916955..1917302 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27144405" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513960.1" /translation="MNAIENQFILPTLTATNLNFIPEPFKTGFDITNKKKRICTFMMK RPFDSTTIFHIRLNLKKGVGGDFMFGEGFYPTCSTMPYLLNCTSDWVKVKLKYTLHYI LYEESELFYQMLN*" gene 1916955..1917302 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" S_feature 1917098..1917430 /Source="Nicolas_S_feature" /locus_tag="new_1917098_1917430" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T0.0H, T-1.10H, T2.30H, Salt, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.66836499999999999" /TUshortSig="SigWXY, Sig-, SigK" /TUshortPSig="1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S658" promotor_-35 1917389..1917398 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1917410..1917425 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1917432..1917610 /Source="Nicolas_S_feature" /locus_tag="new_1917432_1917610" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T-1.10H, T0.0H, T2.30H, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigWXY, Sig-, SigK" /TUshortPSig="0.99, 1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S659" upshifts 1917432 /Source="Nicolas_upshifts" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" misc_RNA 1917501..1917580 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" /product="putative conserved small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" gene 1917501..1917580 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" downshifts 1917567 /Source="Nicolas_upshifts" /id="D973" /incds=0 /nref=16 /ntot=188 /MaxReadThrough="2.99425" /MaxDrop="4.30173" /score="-1.31226475" /energy="-14.3" /TU="U1433" /idTUdmin="U1434" /TUdmin=3 /isTUend="TRUE" CDS complement(1917639..1918256) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the SOS regulon" /protein_id="NP_389668.1" /db_xref="EnsemblGenomes-Gn:BSU17850" /db_xref="EnsemblGenomes-Tr:CAB13669" /db_xref="GOA:P31080" /db_xref="InterPro:IPR006197" /db_xref="InterPro:IPR006199" /db_xref="InterPro:IPR006200" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR036286" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10678" /db_xref="UniProtKB/Swiss-Prot:P31080" /translation="MTKLSKRQLDILRFIKAEVKSKGYPPSVREIGEAVGLASSSTVH GHLARLETKGLIRRDPTKPRAIEILDEEVDIPQSQVVNVPVIGKVTAGSPITAVENIE EYFPLPDRMVPPDEHVFMLEIMGDSMIDAGILDKDYVIVKQQNTANNGEIVVAMTEDD EATVKRFYKEDTHIRLQPENPTMEPIILQNVSILGKVIGVFRTVH*" gene complement(1917639..1918256) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" downshifts complement(1917640) /Source="Nicolas_upshifts" /id="D974" /incds=0 /nref=186 /ntot=254 /MaxReadThrough="2.74616" /MaxDrop="7.90985" /score="8.16083322" /energy="-16.3" /TU="U1435" /idTUdmin="U1435" /TUdmin="-44" /isTUend="FALSE" promotor_-10 complement(1918280..1918299) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1918301) /Source="Nicolas_upshifts" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" promotor_-35 complement(1918313..1918320) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1918336..1918343 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1918355 /Source="Nicolas_upshifts" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" promotor_-10 1918357..1918376 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1918406..1918723 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12581363, 16267290, 16549676, 20400548, 20807205, 23728628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12581363, 16267290, 16549676, 20400548, 20807205, 23728628; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="NP_389669.1" /db_xref="EnsemblGenomes-Gn:BSU17860" /db_xref="EnsemblGenomes-Tr:CAB13670" /db_xref="GOA:Q45056" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR022887" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11820" /db_xref="UniProtKB/Swiss-Prot:Q45056" /translation="MIMSKESIIFVGLFTVILSAVILMLSYTSSGQELNQYVKIEVQQ GDTLWSIADQVADTKKINKNDFIEWVADKNQLQTSDIQPGDELVIPLKKKHQDAYELA TVR*" gene 1918406..1918723 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" promotor_-10 complement(1918423..1918441) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1918426) /Source="Nicolas_upshifts" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1918455..1918462) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1918742..1919395 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" /function="16.9: Replicate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12581363, 16267290, 17020588, 19060143, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase, resolvase" /protein_id="NP_389670.1" /db_xref="EnsemblGenomes-Gn:BSU17870" /db_xref="EnsemblGenomes-Tr:CAB13671" /db_xref="GOA:Q45057" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG11821" /db_xref="UniProtKB/Swiss-Prot:Q45057" /translation="MKALIYARVSTNKEQQETSLKRQEEELTAIAAENGMEVVKVISE KASGYEMDRDGVFELLDEIKNADIDVILVQDETRLGRGNAKIALLHCIYREGVKVYTT AHRGELELSEADSMVLEIVSIVEEYQRKIHNMKIRRGMKRAVKNGFKPQKNLKNQHGN SGKEKIEVPISEIVRLRANKLTFAEIAATLRGFGYDVSKATVHRRFQEYIENEETAE* " gene 1918742..1919395 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" promotor_-35 1919398..1919405 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-35" promotor_-10 1919419..1919438 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-10" upshifts 1919432 /Source="Nicolas_upshifts" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" CDS 1919459..1919692 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12581363, 16267290, 18431750,19306341, 22333191, 22933559, 23099262" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389671.1" /db_xref="EnsemblGenomes-Gn:BSU17880" /db_xref="EnsemblGenomes-Tr:CAB13672" /db_xref="GOA:O31818" /db_xref="InterPro:IPR009242" /db_xref="PDB:2HEP" /db_xref="PDB:2JVD" /db_xref="PDB:3BHP" /db_xref="SubtiList:BG13466" /db_xref="UniProtKB/Swiss-Prot:O31818" /translation="MISNAKIARINELAAKAKAGVITEEEKAEQQKLRQEYLKGFRSS MKNTLKSVKIIDPEGNDVTPEKLKREQRNNKLH*" gene 1919459..1919692 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" S_feature 1919693..1919828 /Source="Nicolas_S_feature" /locus_tag="new_1919693_1919828" /HighExp="M40t90, M40t45, dia15, C90, Etha, H2O2, T5.0H, Salt, dia5, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S660" promotor_-35 1919796..1919803 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-35" promotor_-10 1919817..1919836 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-10" upshifts 1919830 /Source="Nicolas_upshifts" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" CDS 1919861..1921864 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" /EC_number="2.2.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696621, 12682299, 12882400, 27739585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696621, 12682299, 12882400, 27739585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transketolase" /protein_id="NP_389672.1" /db_xref="EnsemblGenomes-Gn:BSU17890" /db_xref="EnsemblGenomes-Tr:CAB13673" /db_xref="GOA:P45694" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005478" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033247" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11247" /db_xref="UniProtKB/Swiss-Prot:P45694" /translation="MDTIEKKSVATIRTLSIDAIEKANSGHPGMPMGAAPMAYTLWTK FMNVSPANPGWFNRDRFVLSAGHGSALLYSMLHLSGFDLSIEDLKGFRQWGSKTPGHP EFGHTAGVDATTGPLGQGIAMAVGMAIAERHLAETYNRDSFNVVDHYTYSICGDGDLM EGISSEAASLAGHLQLGRLIVLYDSNDISLDGDLDRSFSENVKQRFEAMNWEVLYVED GNNIEELTAAIEKARQNEKKPTLIEVKTTIGFGSPNRAGTSGVHGAPLGKEESKLTKE AYAWTYEEDFYVPSEVYEHFAVAVKESGEKKEQEWNAQFAKYKEVYPELAEQLELAIK GELPKDWDQEVPVYEKGSSLASRASSGEVLNGLAKKIPFFVGGSADLAGSNKTTIKNA GDFTAVDYSGKNFWFGVREFAMGAALNGMALHGGLRVFGGTFFVFSDYLRPAIRLAAL MGLPVTYVFTHDSIAVGEDGPTHEPVEQLASLRAMPNLSLIRPADGNETAAAWKLAVQ STDHPTALVLTRQNLPTIDQTSEEALAGVEKGAYVVSKSKNETPDALLIASGSEVGLA IEAQAELAKENIDVSVVSMPSMDRFEKQSDEYKNEVLPADVKKRLAIEMGSSFGWGKY TGLEGDVLGIDRFGASAPGETIINEYGFSVPNVVNRVKALINK*" gene 1919861..1921864 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" misc_feature complement(1920065..1920084) /Source="Nicolas_upshift_promotors" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1920082) /Source="Nicolas_upshifts" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1921854 /Source="Nicolas_upshifts" /id="D975" /incds=0 /nref=230 /ntot=257 /MaxReadThrough="4.5478" /MaxDrop="6.66676" /score="16.4587041" /energy="-10.6" /TU="U1439" /idTUdmin="U1436" /TUdmin=0 /isTUend="TRUE" S_feature complement(1921866..1922524) /Source="Nicolas_S_feature" /locus_tag="new_1921866_1922524_c" /HighExp="Lbstat, C30, Salt, BC, S7, LPhT, S8, M0t90, T-0.40H, Glucon" /AntisenseName="yneE" /AntisenseCor="4.3891878649396997E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.604, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S661" upshifts 1921964 /Source="Nicolas_upshifts" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" misc_feature 1921965..1921984 /Source="Nicolas_upshift_promotors" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1922017..1922463 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" /experiment="publication(s) with functional evidences, PMID:19682252, 25041308, 22720735, 27489185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682252, 25041308, 22720735, 27489185; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor controlling DNA replication" /protein_id="NP_389673.1" /db_xref="EnsemblGenomes-Gn:BSU17900" /db_xref="EnsemblGenomes-Tr:CAB13674" /db_xref="GOA:P45707" /db_xref="InterPro:IPR019683" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG11248" /db_xref="UniProtKB/Swiss-Prot:P45707" /translation="MERHYYTYLIKEEFANHYFGRESVMFELFQDYHWTSLEKQQYEM TEKQIQYITQPIPILHMHQRLKMNLNKTDYRQLDYIYRIALPKAKGHATFMMKEHMIE IVASGDYEAETIFFEVLRKVSPCFLAMDFNSKRYGWLNPVKERNFV*" gene 1922017..1922463 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" misc_feature 1922487..1922506 /Source="Nicolas_upshift_promotors" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1922495 /Source="Nicolas_upshifts" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" promotor_-10 complement(1922506..1922523) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1922524) /Source="Nicolas_upshifts" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" promotor_-35 complement(1922542..1922546) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1922549..1922767 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_389674.1" /db_xref="EnsemblGenomes-Gn:BSU17910" /db_xref="EnsemblGenomes-Tr:CAB13675" /db_xref="GOA:P45708" /db_xref="InterPro:IPR005359" /db_xref="SubtiList:BG11249" /db_xref="UniProtKB/Swiss-Prot:P45708" /translation="MTLWVGILVGVVALLIGVALGFFIARKYMMSYLKKNPPINEQML RMMMMQMGMKPSQKKINQMMKAMNNQTK*" gene 1922549..1922767 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" downshifts 1922779 /Source="Nicolas_upshifts" /id="D976" /incds=0 /nref=243 /ntot=260 /MaxReadThrough="3.51446" /MaxDrop="7.54782" /score="0.133420982" /energy="-4.3" /TU="U1441,U1442" /idTUdmin="U1439" /TUdmin=287 /isTUend="FALSE" S_feature 1922824..1923123 /Source="Nicolas_S_feature" /locus_tag="new_1922824_1923123" /HighExp="S4, S3, S5, G180, S8, T5.0H, LoTm, G135, S6, S7" /AntisenseName="ynzD" /AntisenseCor="-0.33023056016157298" /AntisenseRegPval="-7.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S662" CDS complement(1922841..1923014) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11679073, 15187183, 17350627, 22303282, 23378509, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11679073, 15187183, 17350627, 22303282, 23378509, 27965289; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Spo0A-P phosphatase" /protein_id="NP_389675.1" /db_xref="EnsemblGenomes-Gn:BSU17920" /db_xref="EnsemblGenomes-Tr:CAB13676" /db_xref="GOA:O31819" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG13467" /db_xref="UniProtKB/Swiss-Prot:O31819" /translation="MIREHLLKEIEKKRAELLQIVMANGMTSHITIELSQELDHLLIQ YQKQRLRAVAGDE*" gene complement(1922841..1923014) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" downshifts complement(1922854) /Source="Nicolas_upshifts" /id="D977" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="4.0851" /MaxDrop="5.22565" /score="1.92055758" /energy="-4.3" /TU="U1444,U1446" /idTUdmin="U1444" /TUdmin="-88" /isTUend="FALSE" promotor_-10 complement(1923052..1923071) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1923059) /Source="Nicolas_upshifts" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" promotor_-35 complement(1923085..1923092) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1923094..1923102 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1923114..1923133) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1923114..1923132 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1923125..1923233 /Source="Nicolas_S_feature" /locus_tag="new_1923125_1923233" /HighExp="T4.0H, T3.30H, T3.0H, S2, Lbstat, T5.0H, T2.30H, S4, T-1.40H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA, SigA" /TUshortPSig="0.999, 1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S663" upshifts 1923125 /Source="Nicolas_upshifts" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" upshifts complement(1923126) /Source="Nicolas_upshifts" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" promotor_-35 complement(1923148..1923155) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1923234..1923941 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" /function="16.10: Respire" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16771673, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16771673, 16850406, 19682263; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome c-type biogenesis protein CcdA; thiol-disulfide oxido-reductase" /protein_id="NP_389676.1" /db_xref="EnsemblGenomes-Gn:BSU17930" /db_xref="EnsemblGenomes-Tr:CAB13677" /db_xref="GOA:P45706" /db_xref="InterPro:IPR003834" /db_xref="SubtiList:BG11240" /db_xref="UniProtKB/Swiss-Prot:P45706" /translation="MGDVNYFLTFGAGFLSFISPCCLPLYPAFLSYITGVSMDDVKTE KLLLQKRSLFHTLCFLLGFSVIFIALGYGTSFIGSLFRDYHDAIRQIGALLIILFGFI TLGVFRPEAMMKERRIHFKHKPSGFLGSVLIGMAFAAGWTPCTGPILAAVITLAGTNP GSAVPYMMLYVLGFAVPFLLLSFFITKLKWIRKNQLFIMKAGGVLMIVIGVLLFFNWM SLIIILLSDLFGGFTGF*" gene 1923234..1923941 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" promotor_-35 1923961..1923968 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1923980..1923999 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1923988 /Source="Nicolas_upshifts" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" CDS 1924030..1924392 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative response regulator (CheY homolog)" /protein_id="NP_389677.1" /db_xref="EnsemblGenomes-Gn:BSU17940" /db_xref="EnsemblGenomes-Tr:CAB13678" /db_xref="GOA:P45709" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11250" /db_xref="UniProtKB/Swiss-Prot:P45709" /translation="MTRVLVVDDAKFMRVKIREILEEANYIIAGEAADGEQAADLYKK LRPDLVTMDITMPVKNGIKALRDILTFDPKAKVIMCTAMRQQRIVTEAIELGAKDFIV KPFEETKVLEAVSRVMGH*" gene 1924030..1924392 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" promotor_-35 1924410..1924413 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1924428..1924447 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1924439 /Source="Nicolas_upshifts" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" CDS 1924471..1924962 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389678.1" /db_xref="EnsemblGenomes-Gn:BSU17950" /db_xref="EnsemblGenomes-Tr:CAB13679" /db_xref="GOA:P45710" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR031306" /db_xref="SubtiList:BG11251" /db_xref="UniProtKB/Swiss-Prot:P45710" /translation="MISMMIIVSSIIAVLMAVAVMVVRIKSSDKPVSPKKIILPPIFM STGALMFLFPVFWVTGAEFLEAFTLGVIFSIFLIKTSKFEIKNNEIYMKRSKAFVFIL VGLLVIRIVMKSILSTSIDYGALSGMFWILAFGMIVPWRIAMYLSYRKLHNELQSSNI QMN*" gene 1924471..1924962 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" downshifts 1924958 /Source="Nicolas_upshifts" /id="D978" /incds=0 /nref=110 /ntot=273 /MaxReadThrough="1.09905" /MaxDrop="5.9692" /score="16.4219082" /energy="-9.7" /TU="NA" /idTUdmin="U1445" /TUdmin=2 /isTUend="TRUE" CDS complement(1924993..1925421) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DynA" /protein_id="NP_389679.1" /db_xref="EnsemblGenomes-Gn:BSU17960" /db_xref="EnsemblGenomes-Tr:CAB13680" /db_xref="InterPro:IPR020203" /db_xref="SubtiList:BG11252" /db_xref="UniProtKB/Swiss-Prot:P45711" /translation="MLEGWFLWFILFWVIMMVVLLSIGGFFMFRKFLKRLPKEDGRSE LDWQDYYIENSRHLWNDENKQFLDELTAPVPELFRDAAKAKIAGKIGELALKEKVAKI DQQLMIKGYILATPKRDHTFLKRHLRDKKIDLEPYQTLLK*" gene complement(1924993..1925421) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" downshifts complement(1925010) /Source="Nicolas_upshifts" /id="D979" /incds=0 /nref=188 /ntot=245 /MaxReadThrough="1.60911" /MaxDrop="5.09033" /score="10.710816" /energy="-9.7" /TU="NA" /idTUdmin="U1449" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1925439..1925458) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1925451) /Source="Nicolas_upshifts" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" S_feature complement(1925453..1925538) /Source="Nicolas_S_feature" /locus_tag="new_1925453_1925538_c" /HighExp="S8, S6, S7, LBGstat, C30, dia15, S0, Cold, T1.0H, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.958, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S664" promotor_-35 complement(1925472..1925479) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1925509..1925518 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1925528..1925637 /Source="Nicolas_S_feature" /locus_tag="new_1925528_1925637" /HighExp="S8, BT, B36, S7, G/S, Pyr, B60, S6, Glucon, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S665" upshifts 1925528 /Source="Nicolas_upshifts" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" promotor_-10 1925531..1925550 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1925533..1925552) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1925538) /Source="Nicolas_upshifts" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" S_feature complement(1925540..1925623) /Source="Nicolas_S_feature" /locus_tag="new_1925540_1925623_c" /HighExp="S8, S6, S7, C30, BT, S5, Pyr, Glucon, BC, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S666" promotor_-35 complement(1925567..1925570) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1925594 /Source="Nicolas_upshifts" /id="D980" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="3.76639" /MaxDrop="5.34013" /score="5.70696998" /energy="-12.7" /TU="U1450" /idTUdmin="U1450" /TUdmin="-44" /isTUend="FALSE" CDS complement(1925655..1926047) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9068633, 11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068633, 11150673; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389680.1" /db_xref="EnsemblGenomes-Gn:BSU17970" /db_xref="EnsemblGenomes-Tr:CAB13681" /db_xref="GOA:Q45058" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11822" /db_xref="UniProtKB/Swiss-Prot:Q45058" /translation="MWRNASMNHSKRNDANDFDSMDEWLRQFFEDPFAWYDETLPIDL YETSQQYIIEADLTFLQPTQVTVTLSGCEFILTVKSSGQTFEKQMMLPFYFNDKNIQV ECENQILTVAVNKETEDGSSFSLQFPLS*" gene complement(1925655..1926047) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" downshifts complement(1925668) /Source="Nicolas_upshifts" /id="D981" /incds=0 /nref=20 /ntot=92 /MaxReadThrough="4.44864" /MaxDrop="4.9615" /score="11.5991121" /energy="-12.7" /TU="U1454" /idTUdmin="U1456" /TUdmin=486 /isTUend="FALSE" promotor_-35 1925890..1925895 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-35" promotor_-10 1925911..1925929 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-10" upshifts 1925915 /Source="Nicolas_upshifts" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" promotor_-35 1926025..1926029 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1926039..1926053 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1926054..1926073) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1926056 /Source="Nicolas_upshifts" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(1926069) /Source="Nicolas_upshifts" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" promotor_-35 complement(1926087..1926096) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1926128..1926274) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389681.1" /db_xref="EnsemblGenomes-Gn:BSU17980" /db_xref="EnsemblGenomes-Tr:CAB13682" /db_xref="GOA:P71032" /db_xref="InterPro:IPR012614" /db_xref="SubtiList:BG11921" /db_xref="UniProtKB/Swiss-Prot:P71032" /translation="MTNKNTSKDMHKNAPKGHNPGQPEPLSGSKKVKNRNHTRQKHNS SHDM*" gene complement(1926128..1926274) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" downshifts complement(1926149) /Source="Nicolas_upshifts" /id="D982" /incds=0 /nref=42 /ntot=61 /MaxReadThrough="1.80349" /MaxDrop="6.88836" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1456" /TUdmin=5 /isTUend="TRUE" CDS complement(1926306..1926452) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018, 10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018, 10806362; Product type s: structure" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389682.1" /db_xref="EnsemblGenomes-Gn:BSU17990" /db_xref="EnsemblGenomes-Tr:CAB13683" /db_xref="GOA:P71031" /db_xref="InterPro:IPR012613" /db_xref="SubtiList:BG11920" /db_xref="UniProtKB/Swiss-Prot:P71031" /translation="MVKRKANHVINGMNDAKSQGKGAGYIENDQLVLTEAERQNNKKR KTNQ*" gene complement(1926306..1926452) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" S_feature 1926452..1926585 /Source="Nicolas_S_feature" /locus_tag="new_1926452_1926585" /HighExp="S8, S7, S3, S6, LoTm, S4, S5, BT, Pyr, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S667" upshifts 1926452 /Source="Nicolas_upshifts" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 1926463..1926465 /Source="Nicolas_upshift_promotors" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(1926468..1926479) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1926482) /Source="Nicolas_upshifts" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" promotor_-35 complement(1926494..1926500) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1926575..1926582 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1926587..1926679 /Source="Nicolas_S_feature" /locus_tag="new_1926587_1926679" /HighExp="B60, M40t90, T0.0H, HiOs, T4.0H, T5.0H, T2.30H, M0t90, Sw, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S668" upshifts 1926587 /Source="Nicolas_upshifts" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" promotor_-10 1926597..1926616 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1926638) /Source="Nicolas_upshifts" /id="D983" /incds=0 /nref=1 /ntot=67 /MaxReadThrough="2.77282" /MaxDrop="4.02811" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1458" /TUdmin=0 /isTUend="TRUE" CDS 1926680..1929409 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" /EC_number="4.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate hydratase (bifunctional aconitase)" /protein_id="NP_389683.1" /db_xref="EnsemblGenomes-Gn:BSU18000" /db_xref="EnsemblGenomes-Tr:CAB13684" /db_xref="GOA:P09339" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR006249" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG10478" /db_xref="UniProtKB/Swiss-Prot:P09339" /translation="MANEQKTAAKDVFQARKTFTTNGKTYHYYSLKALEDSGIGKVSK LPYSIKVLLESVLRQVDGFVIKKEHVENLAKWGTAELKDIDVPFKPSRVILQDFTGVP AVVDLASLRKAMAAVGGDPDKINPEIPVDLVIDHSVQVDKAGTEDALAVNMDLEFERN AERYKFLSWAKKAFNNYQAVPPATGIVHQVNLEFLASVVHAIEEDGELVTYPDTLVGT DSHTTMINGIGVLGWGVGGIEAEAGMLGQPSYFPVPEVIGAKLVGKLPNGTTATDLAL KVTQVLREKGVVGKFVEFFGPGIAELPLADRATIANMAPEYGATCGFFPVDEEALNYL RLTGRDPEHIDVVEAYCRSNGLFYTPDAEDPQFTDVVEIDLSQIEANLSGPKRPQDLI PLSAMQETFKKQLVSPAGNQGFGLNAEEENKEIKFKLLNGEETVMKTGAIAIAAITSC TNTSNPYVLIGAGLVAKKAVELGLKVPNYVKTSLAPGSKVVTGYLVNSGLLPYMKELG FNLVGYGCTTCIGNSGPLSPEIEEAVAKNDLLITSVLSGNRNFEGRIHPLVKGNYLAS PPLVVAYALAGTVNINLKTDPIGVGKDGQNVYFNDIWPSMDEINALVKQTVTPELFRK EYETVFDDNKRWNEIETTDEALYKWDNDSTYIQNPPFFEEMSVEPGKVEPLKGLRVVG KFGDSVTTDHISPAGAIGKDTPAGKYLQEKGVSPRDFNSYGSRRGNHEVMMRGTFANI RIKNQIAPGTEGGFTTYWPTGEVTSIYDACMKYKEDKTGLVVLAGKDYGMGSSRDWAA KGTNLLGIRTVIAESFERIHRSNLVFMGVLPLQFKQGENADTLGLTGKEVIEVDVDET VRPRDLVTVRAINEDGNVTTFEAVVRFDSEVEIDYYRHGGILQMVLREKMKQS*" gene 1926680..1929409 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" misc_feature complement(1926700..1926704) /Source="Nicolas_upshift_promotors" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1926704) /Source="Nicolas_upshifts" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature 1929410..1929480 /Source="Nicolas_S_feature" /locus_tag="new_1929410_1929480" /HighExp="M9-stat, B60, M40t90, Glucon, M0t90, MG-0.2, Mal, T2.30H, MG-0.1, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S669" CDS 1929481..1929993 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15342593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane-bound proteins with a thioredoxin-like domain" /protein_id="NP_389684.1" /db_xref="EnsemblGenomes-Gn:BSU18010" /db_xref="EnsemblGenomes-Tr:CAB13685" /db_xref="GOA:O31820" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13451" /db_xref="UniProtKB/Swiss-Prot:O31820" /translation="MLKKWLAGILLIMLVGYTGWNLYQTYSKKEVGIQEGQQAPDFSL KTLSGEKSSLQDAKGKKVLLNFWATWCKPCRQEMPAMEKLQKEYADKLAVVAVNFTSA EKSEKQVRAFADTYDLTFPILIDKKGINADYNVMSYPTTYILDEKGVIQDIHVGTMTK KEMEQKLDLD*" gene 1929481..1929993 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" downshifts 1929950 /Source="Nicolas_upshifts" /id="D984" /incds=0 /nref=115 /ntot=218 /MaxReadThrough="3.76369" /MaxDrop="5.09954" /score="13.5401842" /energy="-6.9" /TU="U1457" /idTUdmin="U1457" /TUdmin="-726" /isTUend="FALSE" promotor_-35 1930019..1930025 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1930038 /Source="Nicolas_upshifts" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" promotor_-10 1930040..1930051 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1930074..1930199 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097732.1" /db_xref="EnsemblGenomes-Gn:BSU18019" /db_xref="EnsemblGenomes-Tr:CAX52626" /db_xref="InterPro:IPR025004" /db_xref="UniProtKB/Swiss-Prot:C0H418" /translation="MKKMRKRSFHELVMENKKELMTNTEYLNQLEEKLEQRFKQK*" gene 1930074..1930199 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" downshifts complement(1930092) /Source="Nicolas_upshifts" /id="D985" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.12259" /MaxDrop="3.48183" /score="-0.0160782027" /energy="-13.9" /TU="NA" /idTUdmin="U1462" /TUdmin=1298 /isTUend="FALSE" promotor_-35 1930213..1930219 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1930234..1930245 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1930236 /Source="Nicolas_upshifts" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" CDS 1930264..1930410 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054579.2" /db_xref="EnsemblGenomes-Gn:BSU18020" /db_xref="EnsemblGenomes-Tr:CAE01455" /db_xref="GOA:Q7WY69" /db_xref="InterPro:IPR012612" /db_xref="SubtiList:BG14179" /db_xref="UniProtKB/Swiss-Prot:Q7WY69" /translation="MGNNKKNGQPQYAPSHLGTKPVKYKANKGEKMHDTSGQRPIIMQ TKGE*" gene 1930264..1930410 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" CDS 1930447..1930698 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (thioredoxin-like protein)" /protein_id="NP_389685.1" /db_xref="EnsemblGenomes-Gn:BSU18030" /db_xref="EnsemblGenomes-Tr:CAB13686" /db_xref="GOA:Q45060" /db_xref="InterPro:IPR017524" /db_xref="SubtiList:BG11806" /db_xref="UniProtKB/Swiss-Prot:Q45060" /translation="MTKNQNQYQQPNPDDRSDNVEKLQDMVQNTIENIEEAEASMEFA SGEDKQRIKEKNARREQSIEAFRNEIQDESAARQNGYRS*" gene 1930447..1930698 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" downshifts 1930676 /Source="Nicolas_upshifts" /id="D986" /incds=0 /nref=41 /ntot=49 /MaxReadThrough="2.07653" /MaxDrop="7.06685" /score="32.1193211" /energy="-7" /TU="NA" /idTUdmin="U1457" /TUdmin=0 /isTUend="TRUE" promotor_-35 1930719..1930724 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1930738..1930757 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1930742..1930833 /Source="Nicolas_S_feature" /locus_tag="new_1930742_1930833" /HighExp="Etha, dia5, dia15, Diami, H2O2, G180, Salt, G150, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S670" upshifts 1930742 /Source="Nicolas_upshifts" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" CDS 1930834..1931199 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" /EC_number="3.1.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11959124, 11994151, 16294310, 18338382; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA thioesterase" /protein_id="YP_054580.1" /db_xref="EnsemblGenomes-Gn:BSU18040" /db_xref="EnsemblGenomes-Tr:CAB13687" /db_xref="GOA:Q45061" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR006684" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11823" /db_xref="UniProtKB/Swiss-Prot:Q45061" /translation="MGIVYHANYLVWMEVGRTALIKDLGFLYSDMEKKGVLSPVVDIN ISYKKPLHYGETAVVHTWIEDYNGFKTVYGYHIYNPAGELSIKATSSHICVDKESFKP IQFRKAFPDWHTAYEKAKK*" gene 1930834..1931199 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" CDS 1931215..1931514 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389687.1" /db_xref="EnsemblGenomes-Gn:BSU18050" /db_xref="EnsemblGenomes-Tr:CAB13688" /db_xref="SubtiList:BG11824" /db_xref="UniProtKB/Swiss-Prot:Q45062" /translation="MAFGVKREELNRWKQAVKRGEIAFLTHYWLDDRFPEAKTVTKAG CADIDKLVQWGAAYGLKKEWIHKKSEFPHFDLLGETQKYILEQENLTDHLIRFHL*" gene 1931215..1931514 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" downshifts 1931490 /Source="Nicolas_upshifts" /id="D987" /incds=0 /nref=55 /ntot=217 /MaxReadThrough="3.04989" /MaxDrop="5.5978" /score="-4.41102273" /energy="-6" /TU="NA" /idTUdmin="U1461" /TUdmin=0 /isTUend="TRUE" CDS complement(1931545..1931832) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 23176286" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389688.1" /db_xref="EnsemblGenomes-Gn:BSU18060" /db_xref="EnsemblGenomes-Tr:CAB13689" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR008326" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11825" /db_xref="UniProtKB/Swiss-Prot:Q45063" /translation="MNMTINEDALNWYKEELDLESGDQVRFFVRYGGCSNVQKGFSLG VAKDAPQEAGVTAEADGITFFIEESDLWYFDNHDLLVSYSEDADEPVFEYQ*" gene complement(1931545..1931832) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" downshifts complement(1931566) /Source="Nicolas_upshifts" /id="D988" /incds=0 /nref=216 /ntot=260 /MaxReadThrough="3.77766" /MaxDrop="7.20006" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-154" /isTUend="FALSE" downshifts complement(1931632) /Source="Nicolas_upshifts" /id="D989" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.5674" /MaxDrop="3.11178" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-220" /isTUend="FALSE" promotor_-10 complement(1931862..1931881) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1931874) /Source="Nicolas_upshifts" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" promotor_-35 complement(1931897..1931904) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1931920..1932501) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphate:glycerol-3-phosphate O-acyltransferase" /protein_id="NP_389689.1" /db_xref="EnsemblGenomes-Gn:BSU18070" /db_xref="EnsemblGenomes-Tr:CAB13690" /db_xref="GOA:Q45064" /db_xref="InterPro:IPR003811" /db_xref="SubtiList:BG11826" /db_xref="UniProtKB/Swiss-Prot:Q45064" /translation="MLIALLIILAYLIGSIPSGLIVGKLAKGIDIREHGSGNLGATNA FRTLGVKAGSVVIAGDILKGTLATALPFLMHVDIHPLLAGVFAVLGHVFPIFAKFKGG KAVATSGGVLLFYAPLLFITMVAVFFIFLYLTKFVSLSSMLTGIYTVIYSFFVHDTYL LIVVTLLTIFVIYRHRANIKRIINKTEPKVKWL*" gene complement(1931920..1932501) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" S_feature 1932502..1932632 /Source="Nicolas_S_feature" /locus_tag="new_1932502_1932632" /HighExp="C30, S8, S7, S5, S6, S4, BC, S3, T4.0H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S671" misc_feature complement(1932527..1932546) /Source="Nicolas_upshift_promotors" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1932544) /Source="Nicolas_upshifts" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" promotor_-35 1932617..1932620 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1932634 /Source="Nicolas_upshifts" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" promotor_-10 1932636..1932655 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1932671..1933078 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA-binding protein" /protein_id="NP_389690.1" /db_xref="EnsemblGenomes-Gn:BSU18080" /db_xref="EnsemblGenomes-Tr:CAB13691" /db_xref="GOA:Q45065" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11827" /db_xref="UniProtKB/Swiss-Prot:Q45065" /translation="MQNPSKAEIKEILQRSKRIAVVGLSDRPDRTSHMVSKAMQDAGY EIIPVNPTIDEALGVKAVSSLKEIDGPIDIVNVFRRSEQLPGVAEEFLETDAPVFWAQ QGLVNEEAYQMLKEKGRTVIMDLCIKVAHAVTK*" gene 1932671..1933078 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" downshifts 1933074 /Source="Nicolas_upshifts" /id="D990" /incds=0 /nref=63 /ntot=221 /MaxReadThrough="4.35976" /MaxDrop="5.49229" /score="-2.11194139" /energy="-6" /TU="U1464" /idTUdmin="U1461" /TUdmin=1584 /isTUend="FALSE" promotor_-35 1933140..1933143 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1933158..1933177 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1933162..1933476 /Source="Nicolas_S_feature" /locus_tag="new_1933162_1933476" /HighExp="H2O2, G150, G180, Etha, Oxctl, LBGexp, dia0, Lbexp, M40t45, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S672" upshifts 1933162 /Source="Nicolas_upshifts" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" CDS 1933477..1935444 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8969507, 9539793, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8969507, 9539793, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit B of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389691.2" /db_xref="EnsemblGenomes-Gn:BSU18090" /db_xref="EnsemblGenomes-Tr:CAB13692" /db_xref="GOA:Q59192" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005740" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11804" /db_xref="UniProtKB/Swiss-Prot:Q59192" /translation="MARKQQFDYNEDAIQVLEGLEAVRKRPGMYIGSTDARGLHHLVY EIVDNSVDEVLAGHGDHIIVKIHKDNSISVQDRGRGMPTGMHKLGKPTPEVILTVLHA GGKFGQGGYKTSGGLHGVGASVVNALSEWLTVTIERDGFVYQQRFENGGKPVTSLEKI GKTKKTGTLTHFKPDPTMFSTTTYNFETLSERLRESAFLLKGLKIELIDERNDQREVF YYENGIEAFVAYLNEEKDVLSEVVSFEGEHHSIEVDFAFQFNDGYSENILSFVNNVRT KDGGTHESGAKTAMTRAFNEYARKVALLKEKDKNLEGTDIREGLSAIISVRIPEELLQ FEGQTKGKLGTSEARSAVDAIVSEQLAYFLEENRDTATLLVKKAIKASQAREAARKAR EEARSGKKRKKSEATLSGKLTPAGSRNPAKNELYLVEGDSAGGSAKQGRDRRFQAVLP LRGKVINTEKAKLADIFKNEEINTIIHAIGGGVGADFSIDDINYDKIIIMTDADTDGA HIQVLLLTFFYRYMKPLIEHGKVFIALPPLYKVSKGSGKKEIIEYAWSDEEMGDVLKK VGKGYTIQRYKGLGEMNADQLWETTMNPESRTLVRVKIDDAARVERRVTTLMGDKVEP RRKWIEKNVAFGLDEESNILENENLSVAEEV*" gene 1933477..1935444 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" CDS 1935448..1937868 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9539793, 12682299, 16267290, 16272394, 24440393" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9539793, 12682299, 16267290, 16272394, 24440393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit A of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389692.2" /db_xref="EnsemblGenomes-Gn:BSU18100" /db_xref="EnsemblGenomes-Tr:CAB13693" /db_xref="GOA:Q45066" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005741" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="SubtiList:BG11803" /db_xref="UniProtKB/Swiss-Prot:Q45066" /translation="MSQPELFHDLPLEEVIGDRFGRYSKYIIQDRALPDARDGLKPVQ RRILYAMHTDGNTFDKNFRKAAKTVGNVIGNYHPHGDSSVYEAMVRMSQDWKVRNVLI EMHGNNGSIDGDPPAAMRYTEARLSPIASELLRDIDKNTVEFVPNFDDTSKEPVVLPA MFPNLLVNGSTGISAGYATDIPPHHLGEVIDAVIKRIQMPSCSVDELMEVIKGPDFPT GGIIQGVDGIRKAYETGKGKIIIRGKAEIETIRGGREQIVITEIPFEVNKANLVKKMD EFRIDKKVEGISEVRDETDRTGLRVVIELKKEADAKGILNFLYKNTDLQITYNFNMVA IHNRRPMLMSLPSILDAYIGHQKEVVTNRSVYELQKAKDRHHIVEGLMKALSILDEVI ATIRSSSDKRDAKNNLIAKYEFTEPQAEAIVSLQLYRLTNTDITALKEEAEELGKKIE ELESILSNDKKLLKVITNSLKALKKKYADTRRSVIEEKIEEIKINLEVMVASEDVYVT VTKDGYLKRTSQRSFAASNGQDFGMKDTDRMLHQFEMNTTDVLLLFTNKGSYIYCPVH QLPDIRWKDMGQHFSNLITIDRDETIVKAIPIKEFDPSAYLLFFTKNGMVKKTELTHY KAQRYSKALVALNLKGEDELIDVHVTNGESQIFMATHLGYGLWFGEDEVNVVGARAAG VKGINLKEDDFVVSGEILQQSDSIVLFTQRGAVKRMSLSEFEKTSRAKRGVVMLRELK KNPHRVVALFACGLEQRLMAETEKGDRKELQTKELRTNDRYSNGSFFFDEEESGKVTA VWRLHTEQ*" gene 1935448..1937868 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" downshifts 1937848 /Source="Nicolas_upshifts" /id="D991" /incds=0 /nref=227 /ntot=255 /MaxReadThrough="0.556700000000001" /MaxDrop="5.87714" /score="9.15080033" /energy="-14.6" /TU="NA" /idTUdmin="U1465" /TUdmin=0 /isTUend="TRUE" S_feature complement(1937876..1938065) /Source="Nicolas_S_feature" /locus_tag="new_1937876_1938065_c" /HighExp="LPhT, B60, Etha, B36, Gly, LoTm, Sw, BC, S8, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99806099999999998" /TUshortSig="SigA, SigA, SigK" /TUshortPSig="0.968, 0.994, 0.642" /TUlongSig="NA" /TUlongPSig="NA" /label="S673" CDS complement(1937915..1938091) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (C-terminus)" /db_xref="PSEUDO:SOX90559.1" /translation="MFNITRLCNENMRRLLNMLFILRMVILGLFSFTALNLFVWQGIE VIHAVTDLFTNHES*" gene complement(1937915..1938091) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /pseudo downshifts complement(1937919) /Source="Nicolas_upshifts" /id="D992" /incds=0 /nref=153 /ntot=267 /MaxReadThrough="0.609599999999999" /MaxDrop="7.72532" /score="38.0779167" /energy="-14.6" /TU="NA" /idTUdmin="U1467" /TUdmin=5 /isTUend="TRUE" CDS complement(1938066..1938476) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU18110" /db_xref="EnsemblGenomes-Tr:CAB13694" /db_xref="GOA:Q45067" /db_xref="PSEUDO:CAB13694.1" /db_xref="SubtiList:BG11828" /db_xref="UniProtKB/Swiss-Prot:Q45067" /translation="MDWGIIIKIFSNIKGGGDHLKKVTILKASILFLAIASFHLFSIP HAFDIGHHYKAVADQQEMHEMKAGQNADDEKKSITGAFTLTALWAMAVLLLTAESKST GYSRRRQRKKSFILAKFYQSSYFGKLHVQHHPIM*" gene complement(1938066..1938476) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /pseudo promotor_-10 complement(1938449..1938468) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1938452) /Source="Nicolas_upshifts" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" promotor_-35 complement(1938483..1938490) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1938517..1938536) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1938518) /Source="Nicolas_upshifts" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" promotor_-35 complement(1938551..1938558) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1938565..1938584) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1938576) /Source="Nicolas_upshifts" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" promotor_-35 complement(1938598..1938607) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1938824..1938829 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1938842..1938861 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1938847 /Source="Nicolas_upshifts" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" S_feature 1938860..1938924 /Source="Nicolas_S_feature" /locus_tag="new_1938860_1938924" /HighExp="Cold, G180, Oxctl, G135, LBGexp, G150, HPh, dia0, Lbexp, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S674" CDS 1938925..1940322 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8969507, 12823818, 15849754, 16850406, 22607086; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+/Na+:nitrogen-donor aminoacid symporter" /protein_id="NP_389694.1" /db_xref="EnsemblGenomes-Gn:BSU18120" /db_xref="EnsemblGenomes-Tr:CAB13695" /db_xref="GOA:Q45068" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG11798" /db_xref="UniProtKB/Swiss-Prot:Q45068" /translation="MESFFNSLINIPSDFIWKYLFYILIGLGLFFTIRFGFIQFRYFI EMFRIVGEKPEGNKGVSSMQAFFISAASRVGTGNLTGVALAIATGGPGAVFWMWVVAA VGMASSFVESTLAQLYKVRDGEDFRGGPAYYIQKGLGARWLGIVFAILITVSFGLIFN AVQTNTIAGALDGAFHVNKIVVAIVLAVLTAFIIFGGLKRVVAVSQLIVPVMAGIYIL IALFVVITNITAFPGVIATIVKNALGFEQVVGGGIGGIIVIGAQRGLFSNEAGMGSAP NAAATAHVSHPAKQGFIQTLGVFFDTFIICTSTAFIILLYSVTPKGDGIQVTQAALNH HIGGWAPTFIAVAMFLFAFSSVVGNYYYGETNIEFIKTSKTWLNIYRIAVIAMVVYGS LSGFQIVWDMADLFMGIMALINLIVIALLSNVAYKVYKDYAKQRKQGLDPVFKAKNIP GLKNAETWEDEKQEA*" gene 1938925..1940322 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" downshifts 1940311 /Source="Nicolas_upshifts" /id="D993" /incds=0 /nref=112 /ntot=203 /MaxReadThrough="3.44078" /MaxDrop="5.75319" /score="16.664707" /energy="-14.7" /TU="U1469" /idTUdmin="U1469" /TUdmin="-23" /isTUend="FALSE" downshifts 1940356 /Source="Nicolas_upshifts" /id="D994" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.22962" /MaxDrop="5.03444" /score="16.664707" /energy="-14.7" /TU="NA" /idTUdmin="U1469" /TUdmin=22 /isTUend="TRUE" S_feature complement(1940412..1941158) /Source="Nicolas_S_feature" /locus_tag="new_1940412_1941158_c" /HighExp="S6, S8, S7, S5, BT, C30, B36, S4, LoTm, B60" /AntisenseName="eglS" /AntisenseCor="0.42607634596628102" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S675" promotor_-35 1940535..1940542 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1940554 /Source="Nicolas_upshifts" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" promotor_-10 1940555..1940574 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1940625..1942124 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" /EC_number="3.2.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3024130, 7704256, 7710279, 15139916, 26907762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3024130, 7704256, 7710279, 15139916, 26907762; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-1,4-beta-glucanase" /protein_id="NP_389695.2" /db_xref="EnsemblGenomes-Gn:BSU18130" /db_xref="EnsemblGenomes-Tr:CAB13696" /db_xref="GOA:P10475" /db_xref="InterPro:IPR001547" /db_xref="InterPro:IPR001956" /db_xref="InterPro:IPR008965" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018087" /db_xref="InterPro:IPR036966" /db_xref="PDB:2L8A" /db_xref="PDB:3PZT" /db_xref="PDB:3PZU" /db_xref="PDB:3PZV" /db_xref="SubtiList:BG10437" /db_xref="UniProtKB/Swiss-Prot:P10475" /translation="MKRSISIFITCLLITLLTMGGMIASPASAAGTKTPVAKNGQLSI KGTQLVNRDGKAVQLKGISSHGLQWYGEYVNKDSLKWLRDDWGITVFRAAMYTADGGY IDNPSVKNKVKEAVEAAKELGIYVIIDWHILNDGNPNQNKEKAKEFFKEMSSLYGNTP NVIYEIANEPNGDVNWKRDIKPYAEEVISVIRKNDPDNIIIVGTGTWSQDVNDAADDQ LKDANVMYALHFYAGTHGQFLRDKANYALSKGAPIFVTEWGTSDASGNGGVFLDQSRE WLKYLDSKTISWVNWNLSDKQESSSALKPGASKTGGWRLSDLSASGTFVRENILGTKD STKDIPETPSKDKPTQENGISVQYRAGDGSMNSNQIRPQLQIKNNGNTTVDLKDVTAR YWYKAKNKGQNFDCDYAQIGCGNVTHKFVTLHKPKQGADTYLELGFKNGTLAPGASTG NIQLRLHNDDWSNYAQSGDYSFFKSNTFKTTKKITLYDQGKLIWGTEPN*" gene 1940625..1942124 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" promotor_-10 complement(1941157..1941176) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1941180) /Source="Nicolas_upshifts" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" promotor_-35 complement(1941190..1941199) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1942072 /Source="Nicolas_upshifts" /id="D995" /incds=0 /nref=1 /ntot=89 /MaxReadThrough="3.59763" /MaxDrop="3.67571" /score="6.04626297" /energy="-10.7" /TU="NA" /idTUdmin="U1470" /TUdmin=1210 /isTUend="FALSE" CDS 1942192..1942455 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389696.1" /db_xref="EnsemblGenomes-Gn:BSU18140" /db_xref="EnsemblGenomes-Tr:CAB13697" /db_xref="InterPro:IPR020302" /db_xref="SubtiList:BG11829" /db_xref="UniProtKB/Swiss-Prot:Q45069" /translation="MDEILKQYMVLYKKMSNMINGPDYPGKEKDIQHQKDQIEVYEKQ LQQGFSTDYDYDVFADSVIKCAYGDMTLEDLEAVYYGLTTPFF*" gene 1942192..1942455 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" downshifts complement(1942714) /Source="Nicolas_upshifts" /id="D996" /incds=0 /nref=4 /ntot=148 /MaxReadThrough="1.78569" /MaxDrop="4.04338" /score="32.2414244" /energy="-12.6" /TU="NA" /idTUdmin="U1472" /TUdmin=6 /isTUend="TRUE" CDS complement(1942714..1943982) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" /EC_number="3.2.1.136" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17028274, 25355936, 26559526, 28330222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17028274, 25355936, 26559526, 28330222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-xylanase" /protein_id="NP_389697.1" /db_xref="EnsemblGenomes-Gn:BSU18150" /db_xref="EnsemblGenomes-Tr:CAB13698" /db_xref="GOA:Q45070" /db_xref="InterPro:IPR001139" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR033452" /db_xref="PDB:3GTN" /db_xref="PDB:3KL0" /db_xref="PDB:3KL3" /db_xref="PDB:3KL5" /db_xref="SubtiList:BG11830" /db_xref="UniProtKB/Swiss-Prot:Q45070" /translation="MIPRIKKTICVLLVCFTMLSVMLGPGATEVLAASDVTVNVSAEK QVIRGFGGMNHPAWAGDLTAAQRETAFGNGQNQLGFSILRIHVDENRNNWYKEVETAK SAVKHGAIVFASPWNPPSDMVETFNRNGDTSAKRLKYNKYAAYAQHLNDFVTFMKNNG VNLYAISVQNEPDYAHEWTWWTPQEILRFMRENAGSINARVIAPESFQYLKNLSDPIL NDPQALANMDILGTHLYGTQVSQFPYPLFKQKGAGKDLWMTEVYYPNSDTNSADRWPE ALDVSQHIHNAMVEGDFQAYVWWYIRRSYGPMKEDGTISKRGYNMAHFSKFVRPGYVR IDATKNPNANVYVSAYKGDNKVVIVAINKSNTGVNQNFVLQNGSASNVSRWITSSSSN LQPGTNLTVSGNHFWAHLPAQSVTTFVVNR*" gene complement(1942714..1943982) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" S_feature complement(1943983..1944112) /Source="Nicolas_S_feature" /locus_tag="new_1943983_1944112_c" /HighExp="Lbstat, BC, M0t90, LBGstat, Sw, T2.0H, M40t90, BI, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99419599999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S676" CDS complement(1944113..1945654) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1938968, 17426966, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1938968, 17426966, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinoxylan arabinofuranohydrolase" /protein_id="NP_389698.1" /db_xref="EnsemblGenomes-Gn:BSU18160" /db_xref="EnsemblGenomes-Tr:CAB13699" /db_xref="GOA:Q45071" /db_xref="InterPro:IPR005084" /db_xref="InterPro:IPR006584" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR023296" /db_xref="PDB:3C7E" /db_xref="PDB:3C7F" /db_xref="PDB:3C7G" /db_xref="PDB:3C7H" /db_xref="PDB:3C7O" /db_xref="SubtiList:BG11807" /db_xref="UniProtKB/Swiss-Prot:Q45071" /translation="MRKKCSVCLWILVLLLSCLSGKSAYAATSTTIAKHIGNSNPLID HHLGADPVALTYNGRVYIYMSSDDYEYNSNGTIKDNSFANLNRVFVISSADMVNWTDH GAIPVAGANGANGGRGIAKWAGASWAPSIAVKKINGKDKFFLYFANSGGGIGVLTADS PIGPWTDPIGKPLVTPSTPGMSGVVWLFDPAVFVDDDGTGYLYAGGGVPGVSNPTQGQ WANPKTARVIKLGPDMTSVVGSASTIDAPFMFEDSGLHKYNGTYYYSYCINFGGTHPA DKPPGEIGYMTSSSPMGPFTYRGHFLKNPGAFFGGGGNNHHAVFNFKNEWYVVYHAQT VSSALFGAGKGYRSPHINKLVHNADGSIQEVAANYAGVTQISNLNPYNRVEAETFAWN GRILTEKSTAPGGPVNNQHVTSIQNGDWIAVGNADFGAGGARSFKANVASTLGGKIEV RLDSADGKLVGTLNVPSTGGAQTWREIETAVSGATGVHKVFFVFTGTGTGNLFNFDYW QFTQR*" gene complement(1944113..1945654) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" S_feature complement(1945655..1945976) /Source="Nicolas_S_feature" /locus_tag="new_1945655_1945976_c" /HighExp="M0t90, LBGstat, T1.30H, T2.30H, BC, M9-stat, T2.0H, T3.0H, T0.30H, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25588499999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S677" promotor_-10 complement(1945966..1945985) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1945977) /Source="Nicolas_upshifts" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" promotor_-35 complement(1946000..1946003) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1946203..1946210 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1946223..1946242 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1946230 /Source="Nicolas_upshifts" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1946249..1946695 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein possibly involved in arabinogalactan metabolism" /protein_id="NP_389699.1" /db_xref="EnsemblGenomes-Gn:BSU18170" /db_xref="EnsemblGenomes-Tr:CAB13700" /db_xref="GOA:O31821" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG13452" /db_xref="UniProtKB/Swiss-Prot:O31821" /translation="MTATRIFYEGRFVTLKEKIKTLGRFCTVGVGNTLIDFGVFFLLT ACHVSYLPAQICSYTAGIVNSYVWNRNWTFCVKRKADGKEIVRFLMINIAASGITFLL LYLFQNCGCSLLVSKLAATIGGMMMNFIGNRIWVFGDSLKNIQDQE*" gene 1946249..1946695 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" CDS 1946702..1947595 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" /EC_number="2.7.7.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8320212, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_389700.1" /db_xref="EnsemblGenomes-Gn:BSU18180" /db_xref="EnsemblGenomes-Tr:CAB13701" /db_xref="GOA:O31822" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13453" /db_xref="UniProtKB/Swiss-Prot:O31822" /translation="MRKKVRKAVIPAAGLGTRFLPATKAQPKEMLPIVDKPAIQYIVE EAAESGIEDILIITGRNKRSIEDHFDRSAELEFNLREKGKTETLKEMQQIADLANIHY IRQKEPLGLGHAVLCAEHFIGDEPFAVLLGDDIMVSETPALRQLMDVYDVYGTEVVGV QSVLPEDVSKYGIINTSGSQGHVYEVNDLVEKPSPEEAPSEIAVMGRYVLNSSIFSVL KTIGRGAGNEIQLTDALREVCRKEPIHARLLEGNRYDIGDKLGCFKASTEIGLMRPEM RSQLLAYLEDVIKRETKEMLR*" gene 1946702..1947595 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" misc_feature 1947212..1947231 /Source="Nicolas_upshift_promotors" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1947220 /Source="Nicolas_upshifts" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" CDS 1947668..1948264 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein, phosphatase or phosphate isomerase" /protein_id="NP_389701.1" /db_xref="EnsemblGenomes-Gn:BSU18190" /db_xref="EnsemblGenomes-Tr:CAB13702" /db_xref="GOA:O31823" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13454" /db_xref="UniProtKB/Swiss-Prot:O31823" /translation="MGSLISEILTWLTNMGYAGIAIGLMIEIIPSEIVLAYGGYMVSE GTIGFIGAIIAGVIGGTIAQIFIYWIGRYGGRPFLDKYGKYLLIKKHHIDMSENWFQK YGAGVVFSARFIPVVRHAISIPAGIARMPFLKFVVLTVLAIIPWSILFVYLGIQLGSQ WDDVENIAGTYTTPIMILAVVVIALYFVIKKRTAIFKR*" gene 1947668..1948264 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" downshifts 1948254 /Source="Nicolas_upshifts" /id="D997" /incds=0 /nref=191 /ntot=259 /MaxReadThrough="1.94273" /MaxDrop="5.58345" /score="15.4353025" /energy="-15" /TU="NA" /idTUdmin="U1474" /TUdmin=0 /isTUend="TRUE" CDS complement(1948313..1949512) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19553197, 22262096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19553197, 22262096; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoribonuclease (nanoRNase)" /protein_id="NP_389702.1" /db_xref="EnsemblGenomes-Gn:BSU18200" /db_xref="EnsemblGenomes-Tr:CAB13703" /db_xref="GOA:O31824" /db_xref="SubtiList:BG13455" /db_xref="UniProtKB/Swiss-Prot:O31824" /translation="MYHLYSHNDLDGVGCGIVAKLAFGKDVEIRYNSVNGLNAQVQYF LEKAKESNRQDALFITDLAVNEENEERLNEYVHAGGKVKLIDHHKTALHLNEHEWGFV QVEYDDGRLTSATSLLYGYLIENGFMKPTNALDQFTELVRQYDTWEWERYDQKQAKRL NDLFFLLSIDEFEAKMIQRLSTHDEFFFDDFEEKLLDLEDEKIERYLRRKKREMVQTF VHEHCVGIVHAESYHSELGNRLGKDNPHLDYIAILSMGSKRVSLRTIHDYIDVSEIAG RYGGGGHAKASGCSITDEVYELFVAEAFRIDPVRPDAFRNIYNLKGSANGSLYENRAQ MRFFLFPLDNEWNIQINGETQDETFAAFEEAEWFIKRNYAASLVRDEVFVAFLAENLK LANQHRK*" gene complement(1948313..1949512) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" S_feature complement(1949513..1949584) /Source="Nicolas_S_feature" /locus_tag="new_1949513_1949584_c" /HighExp="S5, S7, S4, S8, S6, ferm, nit, LBGstat, T5.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.977" /TUlongSig="NA" /TUlongPSig="NA" /label="S678" promotor_-10 complement(1949572..1949583) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1949584) /Source="Nicolas_upshifts" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" promotor_-35 complement(1949598..1949604) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1949682..1951217) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" /EC_number="6.4.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylcrotonoyl-CoA carboxylase subunit (leucinedegradation)" /protein_id="NP_389703.2" /db_xref="EnsemblGenomes-Gn:BSU18210" /db_xref="EnsemblGenomes-Tr:CAB13704" /db_xref="GOA:O31825" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13456" /db_xref="UniProtKB/Swiss-Prot:O31825" /translation="MLMDYEKERTERAERIRKGGAEKYHQSNREKGKLFVRERLSLLF DDDIELEDAFFAECMSDGLPADGVVTAIGKIGGQTVCVMANDSTVKAGSWGAKTVEKI IRIQEIAEKLNCPLIYLVDSAGARITDQINVFPGRRGAGRIFYNQVKLSGRIPQICLL FGPSAAGGAYIPAFCDIVVMVDGNASMYLGSPRMAEMVIGEKVSLEEMGGARMHCSIS GCGDILAETEEEAIQLVRAYLSYFPANFQEKAPIHEKRPPKHFETPLADVIPQNQNAP FDMHELIERVIDEDSFFEIKALFAPELLTGLARIHGQPVGIVANQPKVKGGVLFHDSA DKAAKFITLCDAFHIPLLFLADIPGFMIGTKVEQAGIIRHGAKMISAMSEATVPKLSV IVRKAYGAGLYAMAGPAFEPDCCLALPTAQIAVMGPEAAVNAVYAKKIAELPEEERAA FISSKREEYKEDINIYRLASEMIIDAVIPANSLRDELAKRLKAYMTKEMTFTNRKHPV YPV*" gene complement(1949682..1951217) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" downshifts complement(1949694) /Source="Nicolas_upshifts" /id="D998" /incds=0 /nref=18 /ntot=38 /MaxReadThrough="1.74923" /MaxDrop="5.31437" /score="-1.4478995" /energy="-11.8" /TU="NA" /idTUdmin="U1477" /TUdmin=0 /isTUend="TRUE" CDS complement(1951228..1952010) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" /EC_number="4.2.1.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglutaconyl-CoA hydratase (leucine degradation)" /protein_id="NP_389704.1" /db_xref="EnsemblGenomes-Gn:BSU18220" /db_xref="EnsemblGenomes-Tr:CAB13705" /db_xref="GOA:O34893" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG13457" /db_xref="UniProtKB/Swiss-Prot:O34893" /translation="MGDSILFTVKNEHMALITLNRPQAANALSAEMLRNLQMIIQEIE FNSNIRCVILTGTGEKAFCAGADLKERIKLKEDQVLESVSLIQRTAALLDALPQPVIA AINGSALGGGLELALACDLRIATEAAVLGLPETGLAIIPGAGGTQRLPRLIGRGKAKE FIYTGRRVTAHEAKEIGLVEHVTAPCDLMPKAEELAAAISANGPIAVRQAKFAINKGL ETDLATGLAIEQKAYEQTIPTKDRREGLQAFQEKRRAVYKGI*" gene complement(1951228..1952010) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" CDS complement(1952031..1952930) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" /EC_number="4.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 16330546, 19935659, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxymethylglutaryl-CoA lyase (leucine degradation)" /protein_id="NP_389705.1" /db_xref="EnsemblGenomes-Gn:BSU18230" /db_xref="EnsemblGenomes-Tr:CAB13706" /db_xref="GOA:O34873" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR013785" /db_xref="PDB:1YDO" /db_xref="SubtiList:BG13458" /db_xref="UniProtKB/Swiss-Prot:O34873" /translation="MPYPKKVTIKEVGPRDGLQNEPVWIATEDKITWINQLSRTGLSY IEITSFVHPKWIPALRDAIDVAKGIDREKGVTYAALVPNQRGLENALEGGINEACVFM SASETHNRKNINKSTSESLHILKQVNNDAQKANLTTRAYLSTVFGCPYEKDVPIEQVI RLSEALFEFGISELSLGDTIGAANPAQVETVLEALLARFPANQIALHFHDTRGTALAN MVTALQMGITVFDGSAGGLGGCPYAPGSSGNAATEDIVYMLEQMDIKTNVKLEKLLSA AKWIEEKMGKPLPSRNLQVFKSS*" gene complement(1952031..1952930) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" CDS complement(1952945..1953166) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type c: carrier" /codon_start=1 /transl_table=11 /product="methylcrotonyl-CoA carboxylase; biotinylated subunit (leucine degradation)" /protein_id="YP_003097733.1" /db_xref="EnsemblGenomes-Gn:BSU18239" /db_xref="EnsemblGenomes-Tr:CAX52627" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR011053" /db_xref="PDB:1Z6H" /db_xref="PDB:1Z7T" /db_xref="PDB:2B8F" /db_xref="PDB:2B8G" /db_xref="UniProtKB/Swiss-Prot:C0H419" /translation="MTVSIQMAGNLWKVHVKAGDQIEKGQEVAILESMKMEIPIVADR SGIVKEVKKKEGDFVNEGDVLLELSNSTQ*" gene complement(1952945..1953166) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" CDS complement(1953181..1954515) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" /EC_number="6.4.1.4" /EC_number="6.3.4.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7915138, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin carboxylase for subunit LdeHB of methylcrotonyl-CoA carboxylase" /protein_id="NP_389706.1" /db_xref="EnsemblGenomes-Gn:BSU18240" /db_xref="EnsemblGenomes-Tr:CAB13707" /db_xref="GOA:O34544" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG13459" /db_xref="UniProtKB/Swiss-Prot:O34544" /translation="MFTKVLIANRGEIAMRIIRTCSRLGIKTVAVYSEADKDAPHTKA ATEAYLIGESRVSESYLNIERIIKTAKKAKADAIHPGYGLLSENSRFAERCKQENIVF IGPSPDIIAKMGSKIEARKAMEAAGVPVVPGVSESLGDIEAACRTASQIGYPVMLKAS AGGGGIGMQRVENEEALKKAYEGNKKRAADFFGDGSMYIEKVIEHARHIEVQLLADQH GHTVHLFERDCSVQRRHQKVIEEAPSPFVDDELRMKIGQTAVKAAKAIGYTNAGTIEF IVDQKQNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLRIAAGHTLTFSQKDIQRNGHA IEVRIYAEDPKTFFPSPGTITAFSLPDQKGVRHECAVAKDSTVTPFYDPMIAKMIVKG QTRTEAIEKLETALRDYRVEGIKTNLPLLIQAAATKAFKEGDVTTDFLKQHL*" gene complement(1953181..1954515) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" CDS complement(1954525..1956174) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" /EC_number="6.2.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12535077, 15213221, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl-CoA synthetase" /protein_id="NP_389707.1" /db_xref="EnsemblGenomes-Gn:BSU18250" /db_xref="EnsemblGenomes-Tr:CAB13708" /db_xref="GOA:O31826" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13460" /db_xref="UniProtKB/Swiss-Prot:O31826" /translation="MAELIHSTIGRLLEQTADAYPDRDAVVYPDRNIRYTYAQFDSLC RQTAKGLMRMGIGKGDHVAIWASNISEWLAVQFATAKIGAVLVTVNTNYQAHELDYLL KQSDAAALIIMDSYRGTSYPDIVNSLIPELQEAKPGQLKSERYPFLKTLIYIGNKRLS GMYHWDDTEILAKTVTDAELEERMNSLDKDNVINMQYTSGTTGFPKGVMLTHFNVINN AANIAECMALTSQDRMCIPVPFFHCFGCVLGVLACVSVGAAMIPVQEFDPVTVLKTVE KEKCTVLHGVPTMFIAELHHPDFDAYDLSTLRTGIMAGSPCPSEVMKAVIERMGMKDI TIAYGQTEASPVITQTRANDSFIRRVETTGRALPHTEVKIVEPGTCQEVQRGMQGELC TRGYHVMKGYYKDKDATRKAINHDGWLFTGDLAVMDEDGYCRITGRLKDMLIRGGENI YPREIEEFLYQHPAVLDVQVVGVPDAKFGEEAAAWIKLKDGKSVSPDELKAYCKGKIA RHKIPRYVIFTDDYPMTASGKIQKYKLREKTIEMFNLSSSQ*" gene complement(1954525..1956174) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" promotor_no_box 1954574..1954674 /Source="Nicolas_upshift_promotors" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1954634 /Source="Nicolas_upshifts" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(1956218..1957360) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" /EC_number="1.3.8.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8655474, 17085570, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isovaleryl-CoA dehydrogenase (leucine degradation)" /protein_id="NP_389708.1" /db_xref="EnsemblGenomes-Gn:BSU18260" /db_xref="EnsemblGenomes-Tr:CAB13709" /db_xref="GOA:O34421" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG13461" /db_xref="UniProtKB/Swiss-Prot:O34421" /translation="MNFELTKEQQMVREMVKDFAKKEIAPHAEHVDQTGEFPMQTFKK MGELGLMGIPFPEEYGGSGGDTISYALAVEEVGKACGSTGLSYAAAVSLGASPLYYFG TEEQKQTHLTPLASGTALGSFGLTEPNAGSDAGGTQTKAISNGDEYVINGEKCWITNA SYARTVIVTAVTGKNKDGKNIISALIVPTDTPGLTITSPYDKMGVRGSNTAEILLEDV RVPAANLLGDPTKGFKQFLYTLDGGRISIAALAVGIAQAALDASLAYAKERKQFGQPI SSFQAIQFKLADMAMEIDLARQMVLKAAWLKDHNRPFTKEAAYAKLFASEMATRACNQ AIQIHGGSGYMKEYGVERMLRDAKLMEIGEGTSEIQRLVIARQLLK*" gene complement(1956218..1957360) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" promotor_-10 complement(1957379..1957397) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1957396) /Source="Nicolas_upshifts" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" promotor_-35 complement(1957413..1957418) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1957451..1957756) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389709.1" /db_xref="EnsemblGenomes-Gn:BSU18270" /db_xref="EnsemblGenomes-Tr:CAB13710" /db_xref="GOA:O34356" /db_xref="InterPro:IPR020509" /db_xref="SubtiList:BG13468" /db_xref="UniProtKB/Swiss-Prot:O34356" /translation="MLTDPAEEAFLPNFLLLGAGTALVLCLVFFLYQKLDQSQFAVIK LGIWGSAVGLLMDTISLWNLPLIFPALSKGQVIAFTIWMVCAYCMYLLIPLILSHKK* " gene complement(1957451..1957756) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" CDS complement(1957746..1957919) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513961.1" /translation="MNMEAVFGHLPLLESEKLVLNKNKIEEKHVQDVFYVFISSLVRC HIIFCAVRRCCVD*" gene complement(1957746..1957919) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" CDS complement(1958027..1959559) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative exported glycoside hydrolase" /protein_id="NP_389710.1" /db_xref="EnsemblGenomes-Gn:BSU18280" /db_xref="EnsemblGenomes-Tr:CAB13711" /db_xref="InterPro:IPR003790" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG13462" /db_xref="UniProtKB/Swiss-Prot:O35015" /translation="MKVCQKSIVRFLVSLIIGTFVISVPFMANAQSDRELRAVWIASV LNIDWPSKKGLSVKEQKQEYIKLLDDVQKMGMNAVIVQIKPTADAFYPSAYGPWSEYL TGVQGKDPGYDPLAFMIEETHKRNLEFHAWFNPYRITMNHTDLNKLSEDHPARKHPDW VAAYGNQLYYHPGIPEARDFIVKGIEEVVKHYDIDAVHMDDYFYPYKIAGQEFPDQAQ YEQYGKDAFSNIDDWRRDNVNQLVKQINQTIKAAKPYVKFGISPFGVWRNAADDPTGS NTKAGVRNYDDLYADTRHWIQEGDIDYIAPQIYWSIGFNAAAYDVLADWWSNEVKNRP VHLYIGQAAYKINNNFDPPWSDPEEYVRQITLNRQLELVKGSMHFSLKDLNKNPLGIK DSLSTDLYSKPALVPQMPWLDNTAPKKPKLTKVTEDKNGNLLQIKDHPSNQKTKETAY YAIYRAEGKKQRTLLATQRKTHEQQTFLDNTADPNKKYTYYVTSADRLHNESKASKRT TK*" gene complement(1958027..1959559) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" downshifts complement(1958038) /Source="Nicolas_upshifts" /id="D999" /incds=0 /nref=7 /ntot=27 /MaxReadThrough="2.27934" /MaxDrop="4.41371" /score="9.43133612" /energy="-8" /TU="NA" /idTUdmin="U1478" /TUdmin="-6" /isTUend="TRUE" promotor_-10 complement(1959594..1959613) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1959594) /Source="Nicolas_upshifts" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" promotor_-35 complement(1959626..1959635) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1959695..1960087) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28163698; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389711.1" /db_xref="EnsemblGenomes-Gn:BSU18290" /db_xref="EnsemblGenomes-Tr:CAB13712" /db_xref="GOA:O34506" /db_xref="InterPro:IPR010773" /db_xref="SubtiList:BG13463" /db_xref="UniProtKB/Swiss-Prot:O34506" /translation="MDRLSFLTFIMLILASYRLTHLIVFDKITEFIRKPFMKKKRIVD QNGHVDEKSVPASNFGYMLNCYWCAGVWCAILIGLGYLFLPRIAIPLIFILAIAGAQA ILETAVGVGVKLIDVLKSLQTMMNDKKS*" gene complement(1959695..1960087) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" downshifts complement(1959726) /Source="Nicolas_upshifts" /id="D1000" /incds=0 /nref=2 /ntot=18 /MaxReadThrough="0.581539999999999" /MaxDrop="2.96298" /score="5.25915686" /energy="-11.4" /TU="NA" /idTUdmin="U1479" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1960115..1960126) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1960122) /Source="Nicolas_upshifts" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" promotor_-35 complement(1960140..1960146) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1960198..1964037) /gene="ppsE" /locus_tag="BSU_18300" /old_locus_tag="BSU18300" /EC_number="2.3.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 12486459, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 12486459, 22720735, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nonribosomal plipastatin synthetase E" /protein_id="NP_389712.1" /db_xref="EnsemblGenomes-Gn:BSU18300" /db_xref="EnsemblGenomes-Tr:CAB13713" /db_xref="GOA:O31827" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020459" /db_xref="InterPro:IPR020802" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11962" /db_xref="UniProtKB/Swiss-Prot:O31827" /translation="MKKGADTMNTIKKIKNIYPLSHMQEGMLFHSFLRKEEGAYVEQS LFTIKGSLSYDWFQRSIQAIIDRHDIFRTVFLPHVPHLSGPRQVVMTEREFHLNSEDI SHLPTNDQNEYIERFKEKDKQKGFDLQKDMLMRISLFKTAKDEHVCIWSHHHILMDGW CLGIVMQEFMQIYQSIHAGKPLSLDPVRPYSTYISWLTNRDKEKAAAYWDTYLKNYSA PSPLPRVSDKETKESYHREDLIFSLNKPLTDKLKETAKQHGVTLATLIQAVWGVMLQQ YNRTDDVVFGAVVSGRPSEIPGVEQMIGLFINTIPIRIKTHQDETFHELLIRCQKEML EAEPFTCQPLFDIQANTALKQELIDHIIVFENYPLQQKIADSADQTDSPLQIDQVQVS EQSGYNFNLVVAPGEELVIKFSYNAFVYDAAWISCIKRQFTQALSTAAQHPHMPIADF SFLDATEKEQIVTQFNNTKTEYPKNHTIIDLFREQAEKTPDHTALVYGNMSISYKELD KRSNALARELIQKGFRKNETAGILAAHSPEFMISVLAVLKAGGAYLPLDAELPPERVS FMLEETQAKMLIVQKGLEQNAAFSGTCIISDAQGLMEENDIPINISSSPDDLAYIMYT SGSTGRPKGVMITNRNVVSLVRNSNYTSASGDDRFIMTGSISFDAVTFEMFGALLNGA SLHIIDKSTMLTPDRFGAYLLENDITVLFLTTALFNQLAQVRADMFRGLHTLYVGGEA LSPALMNAVRHACPDLALHNIYGPTENTTFSTFFEMKRDYAGPIPIGKPISNSTAYIL DTKGRLLPIGVPGELCVGGDGVAKGYLNRVDLTNAVFSPHPFLPGERIYRTGDLARWL PDGNLEYISRIDRQMKIRGKRIEPAEIEARLLEMEGVQEAAVTLREKDGEAQLYTHYV GDHKKTDTDFRADLARVLPDYMIPQHWVRVERMPLTGNGKIDRSALPIPENKPAKRQN IILPRNLVEEELANIWKQVLGVNTISIDDDFFAIGGHSLRALQVIHTLKHQQNIDIPI DFLFEHPTIAQLAEKLYSKQLTAANEQHVIKLNQHGAQNLFCFPPISGFGIYFKDLAL LLNEKAAVYGFHFIEQDTRIEQYVNCMTDIQPEGPYVLLGYSAGGNLAFEVAQAMERK GLEVSDFIIVDAYLKEQPLPIDTGNDESAAYLPEAVREKVMKKKRNYQEYWAQLLNEG HIKASIHFIEAGIHPETSGHTGLTKWEGACGNYSEYTGFGAHKDMLEGTYAEKNADII LDILEKITSNQVILHKR*" gene complement(1960198..1964037) /gene="ppsE" /locus_tag="BSU_18300" /old_locus_tag="BSU18300" downshifts complement(1960210) /Source="Nicolas_upshifts" /id="D1001" /incds=0 /nref=51 /ntot=190 /MaxReadThrough="0.85603" /MaxDrop="4.50208" /score="20.3407616" /energy="-16.7" /TU="NA" /idTUdmin="U1479" /TUdmin="-484" /isTUend="FALSE" CDS complement(1964045..1974856) /gene="ppsD" /locus_tag="BSU_18310" /old_locus_tag="BSU18310" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 16707694, 26284661, 28477175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 16707694, 26284661, 28477175; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nonribosomal plipastatin synthetase D involved in synthesis of plipastatin" /protein_id="NP_389713.2" /db_xref="EnsemblGenomes-Gn:BSU18310" /db_xref="EnsemblGenomes-Tr:CAB13714" /db_xref="GOA:P94459" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR013321" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11961" /db_xref="UniProtKB/Swiss-Prot:P94459" /translation="MTKANSIQDIYPLSYMQEGMLFHSLLQKDSQAYVEQASFTIEGK VNPQFFQNSINALVERHDIFRTIFISQNVSSPQQVVLRERNVIVLEEDITHLNEAEQS QFIEQWKEKDRDRGFHLQKDVLMRIALIQTGESQYSCIWTFHHIMMDGWCLSIVLKEF LHIYASYVNASPITLEPVQPYGKYIKWLMEQDKEQAVSYWDHYLSGHEQQTVLPKQKK TKGKSRQEHVTFSFSKEESSRLSELAAREEVTLSTIFHTIWGILLQKYNNNDDAVFGS VISGRPAEIEGIEHMVGLFINTMPVRVQGAKTPFLQLIKDMQKDRLAAEAYSYHPLYE IQSRSAVKQGLIDHILVFENYPVQQEIQMLNKQEHASDLFQIHNFTVADETNYSFYLM VAPGEEIHIKMNYDAEQHDRSFVLSVKEHLLNAVSQILNNPNLPPEEIDITTDTEKRQ LIGEITDQTPVYETIHAMFEKQAEKTPDAHAVIDQACSLTYRELNKAANRLARHLRMK GVVRQEPVAIMMERSAAFITGVLGILKAGGAIVPVDPHYPADRIRYILHDCGCSHVVS QAHLPSSLEDNYIITHPEDIESKVDGSNIKSVNNADDLLYMIYTSGTTGKPKGVQFEH RNMANLLKFEYTHSGIDFEADVLQFATPSFDVCYQEIFSALLKGGTLHIVPEAIKRDV PQLFAFINKHQTNIVFLPTAFIKMIFSERELANSFPDGVKHLIAAGEQLMISDLFQDV LRKRGIHLHNHYGPSETHVVSTYTIHPGDPIPELPPIGKPIGCTDLYILNHQKQLQPC GVPGELYISGASVARGYVNHDKLTSDKFSSDPFKPDVIMYRTGDLARRLEDGNIEYIG RADNQVKIRGYRIEPQEIEVTLMNHPDISEAAILIWQDQNGEHELCAYYCSVQKLNTI DLRSYMASELPEYMIPAKWIWVDSIPLTPNGKVDRAALPEPDASISGNPYTAPRNLLE AKLSQLFEDVLKNGHIGIQDNFFDNGGHSLKATVLMSRIAKEFHVQVSLKDIFAHPTV EGLALIIREAEQNLYAAIEPAEKRDTYPVSSAQKRIYVLQQLDEGVAYNMPAVLELEG ALDVAKLSAVCKELISRHEPLRTSFVSGADDEPVQRIHTEVPFTLSKETTIEGFVRPF DLSQAPLFRAGLIEVSNEKHVLLVDMHHIISDGVSVQLLIREFTDLYANRQLKPLRIQ YKDYAVWQQKFKKGDSYQKQETYWQQQFSGDLPILELPTDKRRPAERQFIGGKVTFQL DKEITARIKRLAHKNRSTLYMTLLALYSAFLSRLSGQDDIVIGSPIAGRPHADLEAVL GMFVNTLALRTRPAGNKTFEEFLKEVRQTALEAYEHQDYPFEELVDKLGVQREMSRNP LFDTTLVLQNMEQQKLKMNDVQLQWNDLEHPISKFDISLYVTEHDSELFCQFEYSTAL FEKETIQRWASLFTTLVEHTAASPETELDNIPILTKEEERDFIESCHLFEETGYSMNQ TLHYALEQQAEKTPDQAAVIFEDGVMTYKELNEQANRIAWELIGRGVKPETTVAIIGK RSPEMLLGIYGILKAGGAYLPIDPDYPEERISFLLEDSGTNILLLQSAGLHVPEFTGE IVYLNQTNSGLAHRLSNPNVDVLPQSLAYVIYTSGSTGMPKGVEIEHRSAVNFLNSLQ SRYQLKHSDMIMHKTSYSFDASIWELFWWPYAGASVYLLPQGGEKEPEVIAKAIEEQK ITAMHFVPSMLHAFLEHIKYRSVPIKTNRLKRVFSGGEQLGTHLVSRFYELLPNVSIT NSYGPTEATVEAAFFDCPPHEKLERIPIGKPVHHVRLYLLNQNQRMLPVGCIGELYIA GAGVARGYLNRPALTEERFLEDPFYPGERMYKTGDVARWLPDGNVEFLGRTDDQVKIR GYRIEPGEIEAALRSIEGVREAAVTVRTDSGEPELCAYVEGLQRNEVRAQLERLLPGY MVPAYMIEMEQWPVTPSGKLDRNALPAPGGAADAETYTAPRNVTEMKLSQLWEDVLKN GPVGIHDNFFDRGGHSLKATALVSRITKEFDVQVPLKDVFAHPTVEGLATVIREGTDS PYEAIKPAEKQETYPVSSAQKRIYVLQQLEDGGTGYNMPAVLELEGKLNPERMDRAFQ ELIKRHESLRTSFEQDEGGDPVQRIHDEVPFTLQTTVLGARTEQEAAAAFIKPFDLSQ APLFRAQIVKVSDERHLLLVDMHHIISDGVSVNILIQEFGELYNNRKLPALRIQYKDY AVWQEGFKTGDAYKMQEAYWLKQLEGELPVLDLPADHARPPVRSFAGDKVSFTLEPEV ASGLHKLARENGSTLYMVLLAAYTAFLSRLSGQEDIIVGSPIAGRPHKDLEPILGMFV NTLALRTRPEGGKPFVQYLQEVRETALEAFEHQNYPFEELVDKLELTRDMSRNPVFDA MLVVQNNDYEPLHLHDLQMKPAQVSHLVSKFDLTLQASEGDGNIHFLFEYSTALFEKT TIERWASHLTNVLSIIGKNPKVTLNHIDILTQEERHQLLNEFNTGQANQYGVQTISQL FEQQAARTPKASALVSGDKTLTYQELDEWSNGIARALRSRGVKPDTPVGIMMHRSFSM IASILGVWKAGGCYVPIDPEYPKERKRYILSDSGTKLLMTINEADLGVLADFEGEILT IESVEEDDKSPLPQMSSAHHLAYIIYTSGTTGRPKGVMVEHKGIANTLQWRRNAYAFN ETDTILQLFSFSFDGFITSMFTPLLSGAKAVLLHEEEAKDILAIKHQLSRQRITHMII VPVLYRALLDVVQPEDVKTLRVVTLAGEAADRELIARSLAICPHTELANEYGPTENSV ATTVMRHMEKQAYVSIGQPIDGTQVLILNSNHQLQPIGVAGELCIAGTGLARGYVNLP ELTERAFTQNPFKPEARMYRTGDAARWMADGTLEYLGRIDDQVKIRGYRVETKEIESV IRCIKGVKDAAVVAHVTASGQTELSAYVVTKPGLSTNAVRSELQNKLPVFMHPAFIEK LDSLPLSPNGKLDRGALPKPVYNHEGERPFLPPSSKMEQILADIWKEVLGAEKIGTAD SFFELGGDSIKALQVSARLHRIGKQMAVKDLFSHPTIQELAAYIRDSDTSSSQAAVEG DVQWSPVQKWFLSQDIKEKHHFNQSVMLHRSTSVQEDALRKTLKAITCHHDALRMVFT QNEQGKWDQYNRPLSHSDDALYGLQMIDLSAPDGTDGNRPYEPLIKRHVLDIQQKMDL KNGPLLQAGLFHTIDGDFLFLSAHHLVVDGISWRVLLEDLALGYRQAAGGEDIKLPPK TSSFKAYAKKLSDYAESQQLMKQLKYWREAEEYQTEALPFDQIDGTRAHEGQRSTISF TLNDKETAALLKDANSAYNTDTQDMLLASVILALRHWTNQSAFKLSLEGHGREDVLKG IDVSRTIGWFTAIYPLLIKLNADLPDSEESMVHVLKTTKDTLRRVPDKGFGYGVIKYL TPPGKKDINFTGAPEISFNYLGQFESGRTAEVPEEDAFSFSPLGAGGDISTTWNREQS LDISAIAAEGKLTVNMTYDNARFQRKTIEQLSETCRQFLLQLIEHCQNKSETEKTISD FDDQELTEDALQEIADMLSFH*" gene complement(1964045..1974856) /gene="ppsD" /locus_tag="BSU_18310" /old_locus_tag="BSU18310" promotor_-35 1967065..1967068 /Source="Nicolas_upshift_promotors" /id="U1480" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.696303696303696" /psig="0.87012987012987" /xcortree=1814 /SigmaFactorBS="cgtaacagcctccggctttccacacaccaagtatggatgCTA TcatactgaacgaacgaTGCATCATGATGCCTACTGGtgtgtccggcttaacacctcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1967085..1967104 /Source="Nicolas_upshift_promotors" /id="U1480" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.696303696303696" /psig="0.87012987012987" /xcortree=1814 /SigmaFactorBS="cgtaacagcctccggctttccacacaccaagtatggatgCTA TcatactgaacgaacgaTGCATCATGATGCCTACTGGtgtgtccggcttaacacctcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1967086 /Source="Nicolas_upshifts" /id="U1480" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.696303696303696" /psig="0.87012987012987" /xcortree=1814 /SigmaFactorBS="cgtaacagcctccggctttccacacaccaagtatggatgCTA TcatactgaacgaacgaTGCATCATGATGCCTACTGGtgtgtccggcttaacacctcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(1974881..1982548) /gene="ppsC" /locus_tag="BSU_18320" /old_locus_tag="BSU18320" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 16707694, 26284661, 28477175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 16707694, 26284661, 28477175; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="non-ribosomal plipastatin synthetase C involved in synthesis of plipastatin" /protein_id="NP_389714.1" /db_xref="EnsemblGenomes-Gn:BSU18320" /db_xref="EnsemblGenomes-Tr:CAB13715" /db_xref="GOA:P39847" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10972" /db_xref="UniProtKB/Swiss-Prot:P39847" /translation="MPQQPEIQDIYPLSFMQEGMLFHSLYDEQSRAYFEQASFTIHGQ LDLERFQKSMDAVFDRYDIFRTAFIYKNVAKPRQVVLKQRHCPIHIEDISHLNERDKE HCTEAFKEQDKSKGFDLQTDVLMRISILKWAPDHYVCIWSHHHILMDGWCLGIVIKDF LHIYQALGKGQLPDLPPVQPYGTYIKWLMQQDREEAAEYWKKRLQHFEKSTPLPKRTD QIPNGTLQQITFAIPEKETAELQKIAAASGATLNTVFQALWGIMLQKVNRSSDAVFGS VISGRPSELKDVENMVGLFINTIPIRAQSDSLSFSDLVRRMQKDMNEAEAYSYFPLYD IQAQSALKQELIDHIIVFENTPTQQEIEELNQAGSFDFSVKDFEMEEVTNYSCSVKVI PGRTLYVRIHFQTSAYQPSMMSEIKDYLLHMVSDVISDPSLPVSKMTLLDEDKTRKIV SQNNRTVSVSPEAPTLHGLFERQAAVTPERLAIRFSGGSLTYAELDMYASRLAAHLAA RGVTNESIVGVLSERSPDMLIAVLAVLKAGGAYLPLDPAYPKERLSYMLKDSGASLLL TQPGCSAPNFSGETLEVDMTSLECEEVKRHVSASVSDGSLAYVIYTSGSTGQPKGVAV EHRQAVSFLTGMQHQFRLSEDDIVMVKTSFSFDASVWQLFWWALSGASAYLLPPGWEK DSALIVQAIHQENVTTAHFIPAMLNSFLDQAEIERLSDRTSLKRVFAGGEPLAPRTAA RFASVLPQVSLIHGYGPTEATVDAAFYVLDPERDRDRLRIPIGKPVPGARLYVLDPHL AVQPSGVAGELYIAGAGVARGYLNRPALTEERFLEDPFYLGERMYKTGDVARWLPDGN VEFLGRTDDQVKIRGYRIEPGEIEAALRSIEGVREAAVTVRTDSGEPELCAYVEGLQR NEVRAQLQRLLPGYMVPAYMIEMEQWPVTPSGKLDRNALPAPGGAADAETYTAPRNVT EMKLSQLWEDVLKNGPVGIHDNFFDRGGHSLKATALVSRIAKEFDVQVPLKDVFAHPT VEGLATVIREGTDSPYEAIKPAEKQETYPVSSAQKRIYVLQQLEDGGTGYNMPAVLEL EGKLNLERMDRAFKELIKRHESLRTAFEQDAGGDPVQRIHDEVPFTLQTTVLGARTEE EAAAAFIKPFDLSQAPLFRAQIVKVSDERHLLLVDMHHIISDGVSVNILIREFGELYN NRKLPALRIQYKDYAVWQEGFKTGDAYKTQGAYWLKQLEGELPVLDLPADHARPPMRS FAGDKVSFTLDQEVTSGLYKLARENGSTLYMVLLAAYTAFLSRLSGQEDIIVGSPIAG RPHKDLEPILGMFVNTLALRTRPEGGKPFVQYLQEVRETAMEAFEHQDYPFEELVDKL ELTRDMSRNPLFDVMFVLQNMDQESLELDELCLKPAANNGHQTSKFDLTLYAQEQPRG LLTFQMEFSTDLYKKKTIEKWLQYFNNMLLSIIKDNKAALGTINILNEDEAHYLIHEL NRTKIDYPRNETISRLFEMQAEQTPNAVAIVSDTQVFTYEDLNSWANQIASVLQIKGV GPDSVVALLTGRTPELIAGMLGILKAGGAYLPIDSNLPVERIAYMLSDSRAALLLQSE KTEKRLLGIECEQIIIEDIQKQGEAKNVESSAGPHSLAYIIYTSGSTGKPKGVMIEQR SVIRLVKNSNYITFTPEDRLLMTSSIGFDVGSFEIFGPLLNGAALHLSDQQTFLDSHQ LKRYIEHQGITTIWLTSSLFNHLTEQNEQTFSQLKHLIIGGEALSPSHVNRIRNVCPE VSIWNGYGPTENTTFSTCLHIQKTYELSIPIGRPVGNSTAFILNQWGVLQPVGAVGEL CVGGDGVARGYLGRPDLTKEKFVPHPFAPGDRLYRTGDLARWLSDGTIEYVGRIDDQV KVRGYRVELGEIETALRQIDGVKEAAVLARTAQTGSKELFGYISVKAGTNAEQVRSLL ARSLPNYMIPAYIIEMETLPLTSNGKLNRKALPEPDVASKQTYIPPRNELEEQLALIW QEVLGIQRIGIEDSFFELGGDSIKALQVSARLGRYGLSLQVSDLFRHPKIKDLSPFIR KSERIIEQGPIQGDVPWTPVQQWFFSQDIEERHHFNQSVMLFHSGRLSENALRPALKK LAEHHDALRMVYRNDDRRWIQINQGIHESQLYSLRISDLSQSESGWETKIKQEVADLQ QSINLQEGPLLHAALFKTLTGDYLFLAIHHLVVDGVSWRILLEDLSAGYQQAAAGQTI QLPPKTDSYQEYARRIQEYAQSSKLIREEAYWRSVEEQQAAELPYEIPHHVNIDFSKR DSLSFSLTEADTAVLLQNVNHAYGTDTQDILLTAASLAICEWTGGSKLRIAMEGHGRE HILPELDISRTVGWFTSMYPALISFENHRDELGTSVKTVKDTLGRIPNKGVGYGMLKY LTHPENKSITFSKTPEISFNYLGQFNDIERQDTFRPSSLGSGKDITHTWKREQIIEMS AMAADKKLHFNLSYPPARFHRNTMEQLINRIEHFLLDIMKHCAGQQKAEKTLSDFSSQ SLTAEDLDSISSLVEEL*" gene complement(1974881..1982548) /gene="ppsC" /locus_tag="BSU_18320" /old_locus_tag="BSU18320" CDS complement(1982565..1990247) /gene="ppsB" /locus_tag="BSU_18330" /old_locus_tag="BSU18330" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 16707694, 26284661, 28477175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 16707694, 26284661, 28477175; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nonribosomal plipastatin synthetase B involved in synthesis of plipastatin" /protein_id="NP_389715.1" /db_xref="EnsemblGenomes-Gn:BSU18330" /db_xref="EnsemblGenomes-Tr:CAB13716" /db_xref="GOA:P39846" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10971" /db_xref="UniProtKB/Swiss-Prot:P39846" /translation="MAQSAQIQDIYPLSHMQEGMLFHSLMDFSSKAYIEQTSFTITGN LCVDSFQKSLNLLVSRYDIFRTIFIKEVPDLTGPQQVVLSNRELTVYREDISRLADQE QQTLIDAFMTKDREKGFDLQKDPLMRLALFDRGDSQYTCVWTHHHIIMDGWCLGIILK EFFSMYDSLKNNSPVQLGSTVPYSRYIEWLGEQDQEETAAYWSEYLKEYGNTASIPRI KRRTADGNYKADQVSFSLAPDMVEKLTEAAQNWGVTLNTLFMSIWGVLLHRYNAADDA VFGSVISGRPSAIDGIESMVGLFINTVPVRIRSAEGITFSSLVKAVQEDILSSEQHGY YPLYEIQNHSPLKQGLIDHIFVFENYPVQLHQALSVESENDEGALKLSDISMSEQTNY DFNIVIVPGESFYIKFSYNADVYEREEMLRIQGHLKQALDCILTNPDVAVSDINIVPP EEQQVIQLFNETERPYVNKTIPQLFEEQAHKTPEAAALKMGNECWTYRQLQVRANQIA HALIEKGVGSGDIVAVMMGRSMEMPAALLGIWKAGGAYMPLDPHFPAERLSFLLKDSQ AAQLLIEEDLISLIPPSYEGNTITIEHTESYQTEAPNMPPGDLAYLIYTSGTTGRPKG VLVDHHGIANTLQWRREEYSMTEQDISLHLFSYVFDGCVTSLFTPLLSGACVLLTTDD EAKDVLALKRKIARYKVSHMIIVPSLYRVLLEVMTADDAKSLRIVTFAGEAVTPDLLE LNQIICPSAELANEYGPTENSVATTILRHLNKKERITIGHPIRNTKVFVLHGNQMQPI GAAGELCISGAGLARGYYKQQELTQKAFSDHPFLEGERLYRTGDAGRFLPDGTIEYIG RFDDQVKIRGYRIELREIETVLRQAPGVKEAAVLARDVSAEEKELVAYIVPEKGNSLP DLYQHLAGTLPSYMIPASIINISQMPLTSSGKLDRFALPEPENNTSVTYMAPRTLIEA DLAHIWEDVLNKQHIGIRDDFFQLGGQSLKAAALVSRIHKKLNVELPLSEVFSYPTVE SMAVKLMSLKEHAFTQIEPADQRDVYPLSFSQKRLYALHQLADDSTGYNMPAVLELRG NLNRQRLRSVLTELVNRHEALRTVFVLDRDEPVQIIYPEMAFDLKELEMESEQMLESA IETFIKPFYLSSGPLFRACVITMGNNRGFLLLDMHHIIADGVSMSTLVQEFTDLYCGK ELPALNLHYKDFAVWQQEKHPKELYKKQEAYWLGQLGGSLPTLELPLDKTRPRLPDFR GGTIEVNIDKDMADELHRLMAETGTTLYMILLAVYSILLSKLSGQEDIVVGSPAAGRP HADLERVIGMFVNTLAMRSKPEGHKTFSSYLHDIRHLALTAYEHQDYPFEELADKLDT NREVNRNPLFDAMLVLQSSEDFRFEVPGLSISSVTPKHDISKFDLTLHAEEHLSGIRC RFEYSTALFEEETITQWASYFIELVKGVTADTEMRISNMQLLPAAERRLLLEKMGQYA AYPRNENIVSLFEKQVAQYPEHIAVVCGHSQLTYRDLNEKAERAAAMLIKQGVRTGDI VGLMLDRSPDMIIGVLSILKAGGAYLPIDPEYPKERISFMLNDSGAKLLLTERGLNKP ADYTGHILYIDECENNSIPADVNIEEIVTDQPAYVIYTSGTTGQPKGVIVEHRNVISL LKHQNLPFEFNHEDVWTLFHSYCFDFSVWEMFGALLNGSTLVVVSKETARDPQAFRLL LKKERVTVLNQTPTAFYGLMLEDQNHTDHLNIRYVIFGGEALQPGLLQSWNEKYPHTD LINMYGITETTVHVTFKKLSAADIAKNKSNIGRPLSTLQAHVMDAHMNLQPTGVPGEL YIGGEGVARGYLNRDELTADRFVSNPYLPGDRLYRTGDLAKRLSNGELEYLGRIDEQV KVRGHRIELGEIQAALLQYPMIKEAAVITRADEQGQTAIYAYMVIKDQQAANISDIRT YLKNALPDFMLPARMIQIDSIPVTVNGKLDQKALPEPEKQAYTADDISPRNEIETVMA EIWEELLNVDELGVSANFFKLGGDSIKALQVCARLKQRGFETTVREMFEHQTLGELSA RVRKDVRAIDQGPVEGEITWTPIQQWFFSQSLESHHFNQSVMIYRAERFDEAALRKVL KSLVTHHDALRIVCRHEDGRQVQINRGIDLSDEELYALELFDVKDSLTEARNTIEEAA SRMQEHIRLETGPLLHAGLFRTENGDHLFLTIHHLVVDAVSWRILFEDFSTAYKQAVS GESIKLPQKTDSYLTYSQRIADYSISRQVQREAAYWDECENRHIQPIPKDNDAASNTF KDTEVIDFELSRHHTELLLTAAHKAYSTEMNDILLTALGLALQKWTGNNQFKISMEGH GRESYLEDIDISRTVGWFTSIYPVWLDMRDSDHKDKEERLGHLIKQTKDMLHRIPHKG AGYGVLKYISKRWGSQKNSPEISFNYLGQFDQDIQSNAFEVSDIKPGNEISPNWERPY ALDISGAVSSGCLNMHIIYNRFQFEEKTIQTFSRHFKQTLENIIEHCTGKENQEWSAS DFTDEDLTLDELSEIMGAVNKL*" gene complement(1982565..1990247) /gene="ppsB" /locus_tag="BSU_18330" /old_locus_tag="BSU18330" downshifts complement(1986236) /Source="Nicolas_upshifts" /id="D1002" /incds=1 /nref=2 /ntot=18 /MaxReadThrough="4.83331" /MaxDrop="4.93461" /score="20.5621533" /energy="-10.2" /TU="U1481,U1483" /idTUdmin="U1481" /TUdmin="-5742" /isTUend="FALSE" upshifts complement(1986280) /Source="Nicolas_upshifts" /id="U1481" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.962037962037962" /psig="0.000999000999001" /xcortree=13 /SigmaFactorBS="agctaagcgggcaagaggatattgttgtcggttCGCCtgctg ccggaagaccgcACGCTgatctggagcgcgtcatcggaatgttcgtcaatacattggc g" /listShort="ppsC" /GFF_Attribute="listLong" promotor_-10 complement(1986282..1986286) /Source="Nicolas_upshift_promotors" /id="U1481" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.962037962037962" /psig="0.000999000999001" /xcortree=13 /SigmaFactorBS="agctaagcgggcaagaggatattgttgtcggttCGCCtgctg ccggaagaccgcACGCTgatctggagcgcgtcatcggaatgttcgtcaatacattggc g" /listShort="ppsC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1986304..1986307) /Source="Nicolas_upshift_promotors" /id="U1481" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.962037962037962" /psig="0.000999000999001" /xcortree=13 /SigmaFactorBS="agctaagcgggcaagaggatattgttgtcggttCGCCtgctg ccggaagaccgcACGCTgatctggagcgcgtcatcggaatgttcgtcaatacattggc g" /listShort="ppsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1986583..1986587 /Source="Nicolas_upshift_promotors" /id="U1482" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.993006993006993" /xcortree=1818 /SigmaFactorBS="ccagtaggcctcctgttttttgtatagctctttcgggtgctt cTCTTGctgccaaacagcaaaATCCTTATAATGCAGGTTTAaagctggcaactctttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1986600 /Source="Nicolas_upshifts" /id="U1482" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.993006993006993" /xcortree=1818 /SigmaFactorBS="ccagtaggcctcctgttttttgtatagctctttcgggtgctt cTCTTGctgccaaacagcaaaATCCTTATAATGCAGGTTTAaagctggcaactctttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 1986603..1986622 /Source="Nicolas_upshift_promotors" /id="U1482" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.993006993006993" /xcortree=1818 /SigmaFactorBS="ccagtaggcctcctgttttttgtatagctctttcgggtgctt cTCTTGctgccaaacagcaaaATCCTTATAATGCAGGTTTAaagctggcaactctttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1990272..1997957) /gene="ppsA" /locus_tag="BSU_18340" /old_locus_tag="BSU18340" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 14762003, 16707694, 26284661, 26268540" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 14762003, 16707694, 26284661, 26268540; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="non-ribosomal plipastatin synthetase A involved in synthesis of plipastatin" /protein_id="NP_389716.2" /db_xref="EnsemblGenomes-Gn:BSU18340" /db_xref="EnsemblGenomes-Tr:CAB13717" /db_xref="GOA:P39845" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10970" /db_xref="UniProtKB/Swiss-Prot:P39845" /translation="MSEHTYSLTHAQRRVWFTELLEPDTSICNLTACVKFKGNIELDT LEGALNHSISRNDAIRFQLLEGEELEPRLHLTEYKYYPLRIIDFSNVEMIEIEQWIQD QASIPFKLFNSPLFQFYLLRIDSHEVWLFAKFHHIIMDGISLNVMGNQIIDLYQKMKK KDPLPDQPEPSYLSYIEKESQYLQSPRFAKDRLFWTQTFEHPLEYHSLADQTSLQKQS TSASRDTIILSPDLEQTIRIFCEEHKINIISLFMASFYICISRITSKKDLAIGTYYGN RGSKAEKEMLGMFVSSLPIRITVDPDTDFLSFVRTIGREQLSVMRHQRFPYNLLVNEL RNEQKDLHNLIGISMQYQPLQWHNADDFDYETALYFSGYTANELSVQIQERIDNGTIQ LNFDYQNTLFSLEDIKRIQSHLLTILENALKHPHSFIRELDMTNTREKQKLLYEFNKT EAVSPKAFTLHGLFERQAAFTPERLAIRFSGGSLTYAELDMYASRLAAHLAARGVTNE SIVGVLSERSPDMLIAVLAVLKAGGAYLPLDPAYPKERLSYMLKDSGASLLLTQPGCS APNFSGETLEVDMTSLASEKAENHEFTPADGGSLAYVIYTSGSTGQPKGVAVEHRQAV SFLTGMQHQFPLSEDDIVMVKTSFSFDASVWQLFWWSLSGASAYLLPPGWEKDSALIV QAIHQENVTTAHFIPAMLNSFLDQAEIERLSDRTSLKRVFAGGEPLAPRTAARFASVL PQVSLIHGYGPTEATVDAAFYVLDPERDRDRLRIPIGKPVPGARLYVLDPHLAVQPSG VAGELYIAGAGVARGYLNRPALTEERFLEDPFYPGERMYKTGDVARWLPDGNVEFLGR TDDQVKIRGYRIEPGEIEAALRSIEGVREAAVTVRTDSGEPELCAYVEGLQRNEVRAQ LERLLPGYMVPAYMIEMEQWPVTPSGKLDRNALPAPGGAADAETYTAPRNVTEMKLSQ LWEDVLKNGPVGIHDNFFDRGGHSLKATALVSRIAKEFDVQVPLKDVFAHPTVEGLAT VIREGTDSPYEAIKPAEKQETYPVSSAQKRIYVLQQLEDGGTGYNMPAVLELEGKLNP ERMERAFKELIKRHESLRTSFEQDAGGDPVQRIHDEVPFTLQTTVLGERTEQEAAAAF IKPFDLSQAPLFRAQIVKISDERHLLLVDMHHIISDGVSVNILIREFGELYNNRNLPA LRIQYKDYAVWREGFKTGDAYKTQEAYWLKQLEGELPVLDLPADHARPPVRSFAGDKV SFTLDQEVASGLHKLARENGSTLYMVLLAAYTAFLSRLSGQEDIIVGSPIAGRPHKDL EPILGMFVNTLALRTRPEGGKPFVQYLQEVRETALEAFEHQDYPFEELVDKLELTRDM SRNPVFDAMFILQNVEKQDIDLREIKVRPANFAHHISLFDITLIATEISGSICCEMEF STEVFLKATIERWADHFIEFLHEALSTPETSLAQINILSDKEKQKIVFEFNKTQVEFA QKDIPFHRIFEAKAEENPEHIAVIDNETEISYRLLNERANRLARTLQNRKGPKPTVAV LAKRSIDAIVGVLAVMKAGGVYIPIDAHYPKARIEYILRDSGADILLLQRELKHLISN SPESEMSHIFLDDEGSFEESNCNLNLSPAPEEPVYIIYTSGTTGAPKGVIVTYQNFTH AALAWRQIYELDRKPVRLLQIASFSFDVFSGDLARTLTNGGTLIVCPDETRLEPAEIY KIIKSQRITVMESTPALIIPVMEYVYRNQFKLPDLDILILGSDMVKAQDFKTLTDRFG QSMRIINSYGVTEATIDSSFYETSMGGECTGDNVPIGSPLPNVHMYVLSQTDQIQPIG VAGELCIGGAGVAKGYHHKPDLTQMKFTENPFVSGERLYRTGDRACWLPNGTIRLLGR MDYQVKINGYRIETEEIESVLLQTGLVREAAVAVQHDKNGQAGLAAYIVPSDVNTNAL RAALTKELPAYMIPAYLIPLVNMPLTLNGKLDRNALPAPNNVLSRPYTAPVNDLQKTM AYIWEDVLSMSRVGIHDSFFELGGDSIKALQVAARLAAEGWSMTIRDLFRYSTIQELC GHITPLASQADQGPAEGEAELTPIQRRFFGQVHAFHYHYNQSVMLFSEKGFNANALHL ALRKITEHHDAIRMIFQRDQNGHVIQFNRGINHKDHELFGLYISDWTKASLERAHLDE KLAAEETVIQSKMNVEKGPLLQAGLFKTAEGDHLLIALHHLVIDGVSWRILLEDLAAA YQQALEKKEIQLPPKTDSYLSYADGLTQIAESKQLLSEKTYWQTILDAHTAFLPKDIE NVPDKLQMNSDAAAFVLSGDWTEKLLFETQQAYGTDANELLLTALGMALSEWTGHDQI VISTEGHGREGHVPNIDISRTVGWFTSIYPILLDMGIPEPFEDQLAYRIKTTKDMLRR VPNKGTGYGLLTHIGELRHKEPEVSFNYLGQFSEEKEVETFQLSYYQPRYEIAGERER EYELDINALITDGRLHVKAVYTQVFSKHSIECFMDRFHRHLIETIEHCSQKKAREKTL SDFSNKELTLSALSSIEDLVKDL*" gene complement(1990272..1997957) /gene="ppsA" /locus_tag="BSU_18340" /old_locus_tag="BSU18340" S_feature complement(1997958..1998066) /Source="Nicolas_S_feature" /locus_tag="new_1997958_1998066_c" /HighExp="T1.30H, T1.0H, T0.30H, S1, M0t90, T2.30H, LPhT, C90, LoTm, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S679" promotor_-10 complement(1998051..1998070) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1998066) /Source="Nicolas_upshifts" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" promotor_-35 complement(1998084..1998091) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1998340..1999815) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" /EC_number="3.4.16.4" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733705, 9864321, 11160090, 14731276, 17582436, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 9864321, 11160090, 14731276, 17582436, 19758330; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase" /protein_id="NP_389717.1" /db_xref="EnsemblGenomes-Gn:BSU18350" /db_xref="EnsemblGenomes-Tr:CAB13718" /db_xref="GOA:P39844" /db_xref="InterPro:IPR000667" /db_xref="InterPro:IPR012338" /db_xref="PDB:1W5D" /db_xref="PDB:2J9P" /db_xref="SubtiList:BG10969" /db_xref="UniProtKB/Swiss-Prot:P39844" /translation="MKKSIKLYVAVLLLFVVASVPYMHQAALAAEKQDALSGQIDKIL ADHPALEGAMAGITVRSAETGAVLYEHSGDTRMRPASSLKLLTAAAALSVLGENYSFT TEVRTDGTLKGKKLNGNLYLKGKGDPTLLPSDFDKMAEILKHSGVKVIKGNLIGDDTW HDDMRLSPDMPWSDEYTYYGAPISALTASPNEDYDAGTVIVEVTPNQKEGEEPAVSVS PKTDYITIKNDAKTTAAGSEKDLTIEREHGTNTITIEGSVPVDANKTKEWISVWEPAG YALDLFKQSLKKQGITVKGDIKTGEAPSSSDVLLSHRSMPLSKLFVPFMKLSNNGHAE VLVKEMGKVKKGEGSWEKGLEVLNSTLPEFGVDSKSLVLRDGSGISHIDAVSSDQLSQ LLYDIQDQSWFSAYLNSLPVAGNPDRMVGGTLRNRMKGTPAQGKVRAKTGSLSTVSSL SGYAETKSGKKLVFSILLNGLIDEEDGKDIEDQIAVILANQ*" gene complement(1998340..1999815) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" downshifts complement(1998352) /Source="Nicolas_upshifts" /id="D1003" /incds=0 /nref=126 /ntot=224 /MaxReadThrough="1.56173" /MaxDrop="5.81468" /score="20.5621533" /energy="-10.2" /TU="NA" /idTUdmin="U1484" /TUdmin="-16" /isTUend="TRUE" CDS complement(1999849..2000826) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" /EC_number="5.1.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9733705, 12753898, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 12753898, 19758330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldose 1-epimerase" /protein_id="NP_389718.1" /db_xref="EnsemblGenomes-Gn:BSU18360" /db_xref="EnsemblGenomes-Tr:CAB13719" /db_xref="GOA:P39840" /db_xref="InterPro:IPR008183" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR014718" /db_xref="PDB:3MWX" /db_xref="PDB:4BZE" /db_xref="PDB:4BZF" /db_xref="PDB:4BZG" /db_xref="PDB:4BZH" /db_xref="SubtiList:BG10253" /db_xref="UniProtKB/Swiss-Prot:P39840" /translation="MANFIEKITYLGTPAIKAGNEHLEMIVVPEWGSNVISLVDKTTN VQLLREPETAESFHDTPTLYGIPILFPPNRISDGTFSFRGRTYHFDINEKDKHNHLHG FLYHEKWNVVTTKQTDEGVIVETEIDLSELPHVQKQFPHHAVVRMTYTIKENTLFKHA TVMNKGKEAFPWGIGYHTTFIFPAESSLFSLTADQQWELDERLLPTGKLMDVPYKEAL HEGMDLRHKQLDDVFLSSYQKRGGENQAVIYHQHAHISIIYKADEQFKHWVVYNADGK QGYLCPEPYTWVTNAVNLDLPSSLTGLQVLEPGEETTAKSSITIELNHQ*" gene complement(1999849..2000826) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" promotor_-10 complement(2000855..2000873) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2000867) /Source="Nicolas_upshifts" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" promotor_-35 complement(2000885..2000893) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2000960..2002351) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven efflux transporter" /protein_id="NP_389719.2" /db_xref="EnsemblGenomes-Gn:BSU18370" /db_xref="EnsemblGenomes-Tr:CAB13720" /db_xref="GOA:O34474" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13548" /db_xref="UniProtKB/Swiss-Prot:O34474" /translation="METSQEPLVTQKKSKPSVWRSMSLFLVPLLLSNVLQSVGQLVGM MAVGRWLGVDAVAAVSSFFPLFFLLISFTIGIGSGSSILIGQAYGAKNEERLKAVVGT TLTFTFLLGVVLAVIGSIFTLDILRLMGTPENVIHVSANYARILFYAMPFMFLYFAYT TFLRGTGDSKTPFYTLIVSTVINIALLPVLILGMFGFPKLGIYGSAYATVISTIATFL VLMVYLRKRKHPLQFDKTVRRYLKMDKELLVLLLRLGVPASINMILVSLSEIAVISFV NHYGSNATAAYGVVNQVASYVQMPAVSLGIAVSIFAAQSIGANEFDRLKQVIRVGIWL NYIIGGVLIILIYVFSHQILSLFLTEQETLYIAHRLLMITLWSYLLFGNAQIISATMR ASGTVLWPTVISIFAIWGVEVPVAFVLSHYTKLEILGVWVGYPAAFAVSLLLIYGYYQ FVWKKKQITRLIQ*" gene complement(2000960..2002351) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" downshifts complement(2000974) /Source="Nicolas_upshifts" /id="D1004" /incds=0 /nref=74 /ntot=213 /MaxReadThrough="2.12119" /MaxDrop="5.14152" /score="31.8413544" /energy="-12.3" /TU="NA" /idTUdmin="U1486" /TUdmin=2 /isTUend="TRUE" downshifts 2001120 /Source="Nicolas_upshifts" /id="D1005" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="1.76262" /MaxDrop="3.63403" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1485" /TUdmin="-1452" /isTUend="FALSE" promotor_-35 2002141..2002147 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-35" promotor_-10 2002161..2002179 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-10" S_feature 2002172..2002505 /Source="Nicolas_S_feature" /locus_tag="new_2002172_2002505" /HighExp="M9-stat, Etha, Gly, S8, Sw, S7, B60, S6, Salt, C30" /AntisenseName="yoeA" /AntisenseCor="9.0133358617756607E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S680" upshifts 2002172 /Source="Nicolas_upshifts" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" S_feature complement(2002352..2002456) /Source="Nicolas_S_feature" /locus_tag="new_2002352_2002456_c" /HighExp="S8, LBGstat, Etha, Cold, S7, T-1.40H, S2, C90, nit, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.456" /TUlongSig="NA" /TUlongPSig="NA" /label="S681" promotor_no_box complement(2002416..2002516) /Source="Nicolas_upshift_promotors" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2002456) /Source="Nicolas_upshifts" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" promotor_-35 2002478..2002483 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2002499..2002517 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2002507 /Source="Nicolas_upshifts" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" promotor_-35 2002565..2002572 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2002585..2002604 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2002588 /Source="Nicolas_upshifts" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" CDS 2002637..2003182 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17483219, 17581128, 18761694, 22720735, 23091053" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483219, 17581128, 18761694, 22720735, 23091053; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of DL-endopeptidases involved in cell-separation" /protein_id="NP_389720.2" /db_xref="EnsemblGenomes-Gn:BSU18380" /db_xref="EnsemblGenomes-Tr:CAB13721" /db_xref="InterPro:IPR031841" /db_xref="PDB:2RSX" /db_xref="SubtiList:BG13549" /db_xref="UniProtKB/Swiss-Prot:O34841" /translation="MKKCLLFLTTIALILSLSTNAFAKNTSGDLSQKQALQLALSARE HFWNTMSGHNPKVKKAVCPSGTFEYQNLQYVYMCSDLGTKAKAVNYLTPIFTKTAIEK GFKDYHFTVSKGKLAVPIGDGDNLLNWKKSTAKLISKKGSTITYEFTVPTLDGSPSAK RKVTFVKENKKWKVNQFDAVI*" gene 2002637..2003182 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" downshifts 2003166 /Source="Nicolas_upshifts" /id="D1006" /incds=0 /nref=164 /ntot=264 /MaxReadThrough="4.38689" /MaxDrop="8.27665" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1487" /TUdmin=0 /isTUend="TRUE" tRNA complement(2003276..2003348) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2003276..2003348) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" downshifts complement(2003374) /Source="Nicolas_upshifts" /id="D1007" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="1.99821" /MaxDrop="3.03097" /score="3.94141467" /energy="-15.1" /TU="NA" /idTUdmin="U1489" /TUdmin=0 /isTUend="TRUE" CDS complement(2003401..2003946) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacteriophage integrase" /protein_id="NP_389721.2" /db_xref="EnsemblGenomes-Gn:BSU18390" /db_xref="EnsemblGenomes-Tr:CAB13722" /db_xref="GOA:O35009" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR013762" /db_xref="SubtiList:BG13550" /db_xref="UniProtKB/Swiss-Prot:O35009" /translation="MHIVQPIRSLEKIQEVKQYLLNKNKRDYFLFIFGINSALRISDI LPLQVKDVQNKDHLWATESKTKKKRKILILESLKQEIYEYTKDMKENEYLFKSVRTRK PISRIQAYRILREAAAACGLEEIGTHTLRKTFGYHFYQRTKDIAELQRILNHSSPSIT MRYIGIDEDTTRAAYKVFGGL*" gene complement(2003401..2003946) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" promotor_-10 complement(2003986..2004005) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2004000) /Source="Nicolas_upshifts" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" promotor_-35 complement(2004019..2004026) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2004262..2004492) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16880568; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excisionase" /protein_id="NP_389722.1" /db_xref="EnsemblGenomes-Gn:BSU18400" /db_xref="EnsemblGenomes-Tr:CAB13723" /db_xref="GOA:O34555" /db_xref="InterPro:IPR010093" /db_xref="SubtiList:BG13551" /db_xref="UniProtKB/Swiss-Prot:O34555" /translation="MYLTIEETAEYTNLSEDYIKSLVLEGKIRAVHDGEQFLIYKEQF KTHLEQLENYKALVQEILNEPIPEDIDVKDED*" gene complement(2004262..2004492) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" downshifts complement(2004276) /Source="Nicolas_upshifts" /id="D1008" /incds=0 /nref=193 /ntot=248 /MaxReadThrough="0.81591" /MaxDrop="5.75977" /score="19.8797745" /energy="-8.6" /TU="NA" /idTUdmin="U1490" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(2004518..2004537) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2004530) /Source="Nicolas_upshifts" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" promotor_-35 complement(2004549..2004555) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2004584..2004603) /Source="Nicolas_upshift_promotors" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2004594) /Source="Nicolas_upshifts" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 2004607..2004614 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2004628..2004647 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2004632 /Source="Nicolas_upshifts" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" CDS 2004677..2006440 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" /EC_number="2.3.2.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8763966, 23335395, 24279353, 26370226, 28120195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763966, 23335395, 24279353, 26370226, 28120195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound gamma-glutamyltranspeptidase" /protein_id="NP_389723.1" /db_xref="EnsemblGenomes-Gn:BSU18410" /db_xref="EnsemblGenomes-Tr:CAB13724" /db_xref="GOA:P54422" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="PDB:2V36" /db_xref="PDB:3A75" /db_xref="PDB:3WHQ" /db_xref="PDB:3WHR" /db_xref="PDB:3WHS" /db_xref="SubtiList:BG11838" /db_xref="UniProtKB/Swiss-Prot:P54422" /translation="MKRTWNVCLTALLSVLLVAGSVPFHAEAKKPPKSYDEYKQVDVG KDGMVATAHPLASEIGADVLKKGGNAIDAAVAIQFALNVTEPMMSGIGGGGFMMVYDG KTKDTTIIDSRERAPAGATPDMFLDENGKAIPFSERVTKGTAVGVPGTLKGLEEALDK WGTRSMKQLITPSIKLAEKGFPIDSVLAEAISDYQEKLSRTAAKDVFLPNGEPLKEGD TLIQKDLAKTFKLIRSKGTDAFYKGKFAKTLSDTVQDFGGSMTEKDLENYDITIDEPI WGDYQGYQIATTPPPSSGGIFLLQMLKILDHFNLSQYDVRSWEKYQLLAETMHLSYAD RASYAGDPEFVNVPLKGLLHPDYIKERQQLINLDQVNKKPKAGDPWKYQEGSANYKQV EQPKDKVEGQTTHFTVADRWGNVVSYTTTIEQLFGTGIMVPDYGVILNNELTDFDAIP GGANEVQPNKRPLSSMTPTILFKDDKPVLTVGSPGGATIISSVLQTILYHIEYGMELK AAVEEPRIYTNSMSSYRYEDGVPKDVLSKLNGMGHKFGTSPVDIGNVQSISIDHENGT FKGVADSSRNGAAIGINLKRK*" gene 2004677..2006440 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" downshifts 2006421 /Source="Nicolas_upshifts" /id="D1009" /incds=0 /nref=24 /ntot=49 /MaxReadThrough="1.41914" /MaxDrop="5.80171" /score="3.23845421" /energy="-10.4" /TU="NA" /idTUdmin="U1492" /TUdmin=0 /isTUend="TRUE" CDS complement(2006541..2007398) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17526699" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family)" /protein_id="NP_389724.1" /db_xref="EnsemblGenomes-Gn:BSU18420" /db_xref="EnsemblGenomes-Tr:CAB13725" /db_xref="GOA:O34685" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13552" /db_xref="UniProtKB/Swiss-Prot:O34685" /translation="MESGDLKIFQAVAREGSITKAAQMLNYVQSNVTARVHNLEEDLN IRLFHRTNRGMKLTAAGENLLQYADQVLSLLDQAEKSTRMSRQPKGPLRIGSLETMAV THLPEHAASFLRRFPEVDLSVNTADTHHLIQQVLDHKVDGAFVYGPVEHAAVRQLHVS HDELVLISSREGTAEDMLQQPMLFFGAGCSHRDRVKRLLEEAGIHNQKIIEFGTLEAI IKGVSAGMGTALLPKSAVDGSEHRTNVWIHQLPPSYQDLEIVFIYRKDFFITSAFQTF LDEINEMKR*" gene complement(2006541..2007398) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" promotor_-10 complement(2007444..2007463) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2007464) /Source="Nicolas_upshifts" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" promotor_-35 complement(2007477..2007484) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2007526..2008515 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 23873705; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389725.1" /db_xref="EnsemblGenomes-Gn:BSU18430" /db_xref="EnsemblGenomes-Tr:CAB13726" /db_xref="GOA:O35017" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13553" /db_xref="UniProtKB/Swiss-Prot:O35017" /translation="MKAVIHNGKAGLLGLSVQDVPSTKPGYGEVKVKLKSAGLNHRDL FLMKNKSEQDPHMILGSDGAGIIEEIGEGVKNVTVQTEVVIFPTLNWDLTENVPPVPE ILGGPSDGTLAEYVIIPSQNAIKKPAYLSWEEAGVLPLSALTAYRALFTKGQLKKGEH LLIPGIGSGVATYALFMAKAIGATVSVTSRSEEKRKKALKLGADYAFDSYSNWDEQLQ GKKIDVVLDSIGPALFSEYFRHVKPNGRIVSFGASSGDNLSFPVRSLFFPQVNVLGTS MGSGEEFQAMLAFIDKHKLRPVIDRIYPLEKACEAYKRMQEGRQFGNIGIVME*" gene 2007526..2008515 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" S_feature complement(2007582..2008540) /Source="Nicolas_S_feature" /locus_tag="new_2007582_2008540_c" /HighExp="T-4.40H, T-5.40H, Glu, GM 45, Glucon, GM-0.1, Gly, GM-0.2, UNK1, GM 90" /AntisenseName="yogA" /AntisenseCor="-0.49303153269799599" /AntisenseRegPval="-17.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S682" CDS complement(2008572..2010053) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3011766, 10651638, 11029411, 27223617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3011766, 10651638, 11029411, 27223617; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (small subunit, NADP-dependent)" /protein_id="NP_389726.2" /db_xref="EnsemblGenomes-Gn:BSU18440" /db_xref="EnsemblGenomes-Tr:CAB13727" /db_xref="GOA:O34399" /db_xref="InterPro:IPR006005" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR028261" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12594" /db_xref="UniProtKB/Swiss-Prot:O34399" /translation="MGKPTGFMEIKREKPAERDPLTRLKDWKEYSAPFSEEASKRQGA RCMDCGTPFCQIGADINGFTSGCPIYNLIPEWNDLVYRGRWKEALERLLKTNNFPEFT GRVCPAPCEGSCTLAISDPAVSIKNIERTIIDKGFENGWIQPRIPKKRTGKKVAIVGS GPAGLASADQLNQAGHSVTVFERADRAGGLLTYGIPNMKLEKGIVERRIKLLTQEGID FVTNTEIGVDITADELKEQFDAVILCTGAQKQRDLLIEGRDSKGVHYAMDYLTLATKS YLDSNFKDKQFIDAKGKDVIVIGGGDTGADCVATALRQKAKSVHQFGKHPKLPPARTN DNMWPEQPHVFTLEYAYEEAEAKFGRDPREYSIQTTKMVADKNGKLKELHTIQMEKVK NEHGKYEFRELPGTEKVWPAQLVFIAIGFEGTEQPLLKQFGVNSVNNKISAAYGDYQT NIDGVFAAGDARRGQSLIVWAINEGREVAREVDRYLMGSSVLP*" gene complement(2008572..2010053) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" downshifts complement(2008585) /Source="Nicolas_upshifts" /id="D1010" /incds=0 /nref=247 /ntot=279 /MaxReadThrough="3.292" /MaxDrop="7.52772" /score="10.4717228" /energy="-6.5" /TU="U1495" /idTUdmin="U1495" /TUdmin="-570" /isTUend="FALSE" CDS complement(2010070..2014632) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (large subunit, NADP-dependent)" /protein_id="NP_389727.2" /db_xref="EnsemblGenomes-Gn:BSU18450" /db_xref="EnsemblGenomes-Tr:CAB13728" /db_xref="GOA:P39812" /db_xref="InterPro:IPR002489" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR006982" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR036485" /db_xref="SubtiList:BG10811" /db_xref="UniProtKB/Swiss-Prot:P39812" /translation="MTYNQMPKAQGLYRPEFEHDACGIGLYAHLKGKQTHDIVKQGLK MLCQLDHRGGQGSDPDTGDGAGLLVQIPDAFFRKECKNINLPEKERYGVGMVFFSQKE DERKKIEKQINALIEQEGQVVLGWRTVPVNVGKIGTVAQKSCPFVRQVFIGASSDLKD NLSFERKLYVIRKQAENWGVTEGLDFYFASLSSQTIVYKGLLTPEQVDAFYSDLQDEA FVSAFALVHSRFSTNTFPTWERAHPNRYLVHNGEINTLRGNINWMRAREQQFVSESFG EDLNKILPILNADGSDSSILDNAFEFFVMAGRKPAHTAMMLIPEPWTENTHMSKEKRA FYEYHSSLMEPWDGPTAISFTDGKQIGAILDRNGLRPARYYVTKDDYIIFSSEVGVIE VEQENVLYKNRLEPGKMLLIDLEEGRIISDEEVKTQIATEYPYQKWLEEELVQVNPDP ESREEEQFSDLLTRQKAFGYTYEDIQKYLIPVIKEGKDPLGSMGNDAPLAVLSDRAQS LFNYFKQLFAQVTNPPIDAIREQLVTSTMTWLGAEGDLLHPSERNVRRIKLYTPVLSN EQFYALKTIVHPDLKSQKIDVLFSEDLERGLKDMFTQAEKAISQGVSLLILSDKKMNE RLTPIPPLLAVSALHQHLIRKGLRTKVSIIVESGEAREVHHFAALIGYGADAINPYLA YATYKQEIDEGRLDISYEEAVSKYGKSITEGVVKVMSKMGISTVQSYRGAQIFEAVGI SRDVIDRYFSGTASQLGGIDLQTIAEEAQRRHREAYQDDYSKTLEPGSDFQWRNGGEH HAFNPKTIHTLQWACRRNDYNLFKQYTKAADEERIGFLRNLFAFDGNRKPLKLEEVES AESIVKRFKTGAMSFGSLSKEAHEALAIAMNRLGGKSNSGEGGEDPKRFVPDENGDDR RSAIKQIASGRFGVKSHYLVNADELQIKMAQGAKPGEGGQLPGNKVYPWVADVRGSTP GVGLISPPPHHDIYSIEDLAQLIHDLKNANRDARISVKLVSKAGVGTIAAGVAKATAD VIVISGYDGGTGASPKTSIKHTGLPWELGLAEAHQTLMLNGLRDRVVLETDGKLMTGR DVVMAALLGAEEFGFATAPLVVLGCVMMRACHLDTCPVGVATQNPELRKKFMGDPDHI VNYMLFIAEEVREYMAALGFKTFDEMIGRTDVLHASERAKEHWKASQLDLSTLLYQPE GVRTFQSPQNHKIDQSLDITTILPAVQEAIESGKEADISIEINNTNRVAGTITGSEIS KRYGEEGLPEDTIKLHFTGSAGQSFGAFVPKGMTLYLDGDSNDYVGKGLSGGKIIVKS SEGFNSASDDNVIIGNVAFYGATSGEAYINGRAGERFAVRNSGVNVVVEGIGDHGCEY MTGGSVVVLGDVGKNFAAGMSGGIAYVLTEDVKAFKRKCNLEMILFESLEDEKEIQQI KAMLERHTAYTNSQKAEDLLDQWEDSVKKFVKVIPKNYKQMLASIEEQKAAGLSDEEA IMFAFEANTKPKQNTAASGQKQAVVQ*" gene complement(2010070..2014632) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" promotor_no_box 2013093..2013193 /Source="Nicolas_upshift_promotors" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2013153 /Source="Nicolas_upshifts" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2014633..2014704) /Source="Nicolas_S_feature" /locus_tag="new_2014633_2014704_c" /HighExp="SMM, T-5.40H, HiOs, MG 15, Glu, T-4.40H, MG 150, MG 60, UNK1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S683" promotor_-10 complement(2014684..2014703) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2014701..2014708 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2014704) /Source="Nicolas_upshifts" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" promotor_-35 complement(2014718..2014725) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2014720 /Source="Nicolas_upshifts" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" promotor_-10 2014723..2014742 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2014779..2015681 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2548995, 15150225, 17134717, 28294562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2548995, 15150225, 17134717, 28294562; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family) (GltC-glutamate)" /protein_id="NP_389728.2" /db_xref="EnsemblGenomes-Gn:BSU18460" /db_xref="EnsemblGenomes-Tr:CAB13729" /db_xref="GOA:P20668" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10810" /db_xref="UniProtKB/Swiss-Prot:P20668" /translation="MELRQLRYFMEVAEREHVSEAADHLHVAQSAISRQIANLEEELN VTLFEREGRNIKLTPIGKEFLIHVKTAMKAIDYAKEQIDEYLDPHRGTVKIGFPTSLA SQLLPTVISAFKEEYPHVEFLLRQGSYKFLIEAVRNRDIDLALLGPVPTNFSDITGKI LFTEKIYALVPLNHPLAKQKTVHLIDLRNDQFVLFPEGFVLREMAIDTCKQAGFAPLV STEGEDLDAIKGLVSAGMGVTLLPESTFAETTPRFTVKIPIEFPQVKRTVGIIKPKNR ELAPSANDFYEFVIQFFSKLEQYQ*" gene 2014779..2015681 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" downshifts 2015661 /Source="Nicolas_upshifts" /id="D1011" /incds=0 /nref=104 /ntot=241 /MaxReadThrough="2.84467" /MaxDrop="3.98111" /score="22.3639229" /energy="-13.6" /TU="NA" /idTUdmin="U1496" /TUdmin=0 /isTUend="TRUE" CDS complement(2015733..2016848) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" /EC_number="2.7.2.11" /function="16.8: Protect" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:11418582, 15804359, 21784929, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 15804359, 21784929, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389729.1" /db_xref="EnsemblGenomes-Gn:BSU18470" /db_xref="EnsemblGenomes-Tr:CAB13740" /db_xref="GOA:O07509" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG12658" /db_xref="UniProtKB/Swiss-Prot:O07509" /translation="MTPDTSMKRVVVKIGSSSLTSLHGEISIRKLEALVDQVVKLKDA GYEVILVSSGAVAAGYRKLGFIQRPEKLPEKQASASIGQGLLMEAYSKLFLAHGYVAS QILITRSDFSDEYRYNNVRNTMNVLLERGIIPIINENDTVTVNRLKFGDNDTLAAKVA GLIDADMLVILSDIDGLYDGNPRTNPEAKKIQRVSEITPDIEACAGDTGSIVGTGGMR SKLDAFKIVMASGIKGFLGQADAGDILYHAVHEQAEGTYFEAEGTLPLNQKEQWIAFN SGPEGEMILSDDCSRKITNGQSSLYLDGVQKIKGKFKSGSVVRLMDSKGTEIGLGIVN YSSVQLQEPEKKKELTNRALIDQEAFVCHVDFSLPVN*" gene complement(2015733..2016848) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" CDS complement(2016845..2017738) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21784929, 22139509, 25344233, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21784929, 22139509, 25344233, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase" /protein_id="NP_389730.2" /db_xref="EnsemblGenomes-Gn:BSU18480" /db_xref="EnsemblGenomes-Tr:CAB13741" /db_xref="GOA:P0CI77" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11049" /db_xref="UniProtKB/Swiss-Prot:P0CI77" /translation="MRTKKRTKEMLPIFDQKKVAFIGAGSMAEGMISGIVRANKIPKQ NICVTNRSNTERLTELELQYGIKGALPNQLCIEDMDVLILAMKPKDAENALSSLKSRI QPHQLILSVLAGITTSFIEQSLLNEQPVVRVMPNTSSMIGASATAIALGKYVSEDLKK LAEALLGCMGEVYTIQENQMDIFTGIAGSGPAYFYYLMEFIEKTGEEAGLDKQLSRSI GAQTLLGAAKMLMETGEHPEILRDNITSPNGTTAAGLQALKKSGGGEAISQAIKHAAK RSKEISEDIEKTAAPLSGVIK*" gene complement(2016845..2017738) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" promotor_-10 complement(2017743..2017762) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2017751 /Source="Nicolas_upshifts" /id="D1012" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="1.17009" /MaxDrop="3.27004" /score="-0.988973561" /energy="-13.3" /TU="NA" /idTUdmin="U1496" /TUdmin=2090 /isTUend="FALSE" upshifts complement(2017761) /Source="Nicolas_upshifts" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" promotor_-35 complement(2017776..2017782) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2017791..2017809) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2017809) /Source="Nicolas_upshifts" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" promotor_-35 complement(2017825..2017830) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2017886..2018254) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11313334, 15657033, 16822523, 17376071, 17521668, 24946150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11313334, 15657033, 16822523, 17376071, 17521668, 24946150; Product type f : factor" /codon_start=1 /transl_table=11 /product="replication terminator protein" /protein_id="NP_389731.1" /db_xref="EnsemblGenomes-Gn:BSU18490" /db_xref="EnsemblGenomes-Tr:CAB13742" /db_xref="GOA:P0CI76" /db_xref="InterPro:IPR003432" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1BM9" /db_xref="PDB:1F4K" /db_xref="PDB:1J0R" /db_xref="PDB:2DPD" /db_xref="PDB:2DPU" /db_xref="PDB:2DQR" /db_xref="PDB:2EFW" /db_xref="SubtiList:BG10738" /db_xref="UniProtKB/Swiss-Prot:P0CI76" /translation="MKEEKRSSTGFLVKQRAFLKLYMITMTEQERLYGLKLLEVLRSE FKEIGFKPNHTEVYRSLHELLDDGILKQIKVKKEGAKLQEVVLYQFKDYEAAKLYKKQ LKVELDRCKKLIEKALSDNF*" gene complement(2017886..2018254) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" promotor_-10 complement(2018289..2018307) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-10" upshifts complement(2018312) /Source="Nicolas_upshifts" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" S_feature complement(2018314..2018433) /Source="Nicolas_S_feature" /locus_tag="new_2018314_2018433_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, LBGtran, LoTm, LBGexp, G180, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S684" promotor_-35 complement(2018319..2018327) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-35" promotor_-10 complement(2018425..2018444) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2018433) /Source="Nicolas_upshifts" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" S_feature complement(2018435..2018531) /Source="Nicolas_S_feature" /locus_tag="new_2018435_2018531_c" /HighExp="Etha, dia15, LBGtran, LoTm, dia5, H2O2, LBGexp, M0t45, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S685" promotor_-35 complement(2018459..2018466) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2018554..2019270) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxido-reductase" /protein_id="NP_389732.1" /db_xref="EnsemblGenomes-Gn:BSU18500" /db_xref="EnsemblGenomes-Tr:CAB13743" /db_xref="GOA:P14802" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11048" /db_xref="UniProtKB/Swiss-Prot:P14802" /translation="MQSLQHKTALITGGGRGIGRATALALAKEGVNIGLIGRTSANVE KVAEEVKALGVKAAFAAADVKDADQVNQAVAQVKEQLGDIDILINNAGISKFGGFLDL SADEWENIIQVNLMGVYHVTRAVLPEMIERKAGDIINISSTAGQRGAAVTSAYSASKF AVLGLTESLMQEVRKHNIRVSALTPSTVASDMSIELNLTDGNPEKVMQPEDLAEYMVA QLKLDPRIFIKTAGLWSTNP*" gene complement(2018554..2019270) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" downshifts complement(2018576) /Source="Nicolas_upshifts" /id="D1013" /incds=0 /nref=109 /ntot=217 /MaxReadThrough="4.9568" /MaxDrop="5.08605" /score="27.1231718" /energy="-7.5" /TU="U1501" /idTUdmin="U1500" /TUdmin="-594" /isTUend="FALSE" promotor_-10 complement(2019308..2019327) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2019317) /Source="Nicolas_upshifts" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" promotor_-35 complement(2019343..2019346) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2019371..2019377 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2019391..2019409 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2019396 /Source="Nicolas_upshifts" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" CDS 2019421..2019726 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16513748, 17598888; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="transition-dependent and sulfur-related metabolism protein" /protein_id="NP_389733.1" /db_xref="EnsemblGenomes-Gn:BSU18510" /db_xref="EnsemblGenomes-Tr:CAB13744" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG11047" /db_xref="UniProtKB/Swiss-Prot:P28670" /translation="MIIVYISLAVLAVSIIFLGVTVIQNKKKIDPALKELSSVTQAMQ KQIEGLKTETELLTQKQKKIQQDVQIKKYTLQQTAAEVKEVPQAVKEVWQAGHFNSR* " gene 2019421..2019726 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" downshifts 2019710 /Source="Nicolas_upshifts" /id="D1014" /incds=0 /nref=6 /ntot=88 /MaxReadThrough="5.31272" /MaxDrop="3.8396" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin="-1473" /isTUend="FALSE" CDS 2019797..2020567 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 17598888, 19703276" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389734.1" /db_xref="EnsemblGenomes-Gn:BSU18520" /db_xref="EnsemblGenomes-Tr:CAB13745" /db_xref="InterPro:IPR020530" /db_xref="InterPro:IPR036895" /db_xref="SubtiList:BG11046" /db_xref="UniProtKB/Swiss-Prot:P28671" /translation="MIINRSCLKEFAEKVHFLPSSLTKSDLLTDPFRLHQENELGIYY SPHNEFINRDASLVIAGITPGFSQMKTAYETAAESLLQGGTLEQMAVDTKIAAGFSGS MRHNLITMLDLCGLPQAFGIQSAAKLFGELRHMLHTTSVIKYPVFIQQKNYTGYKPAI THSPILSTYAFGHFPAELNHVTGPALLIPLGKAAETVCETLIRQHSLQNLICLNGFPH PSGANGHRLKQFSKNKEQLERQIRSFAALVDFAIEKRK*" gene 2019797..2020567 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" promotor_-35 2020549..2020556 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2020568 /Source="Nicolas_upshifts" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" promotor_-10 2020571..2020590 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2020611..2021144 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 11717291, 17598888; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389735.2" /db_xref="EnsemblGenomes-Gn:BSU18530" /db_xref="EnsemblGenomes-Tr:CAB13746" /db_xref="GOA:O34569" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13472" /db_xref="UniProtKB/Swiss-Prot:O34569" /translation="MFPILETDRLILRQITDQDAEAIFACFSNDEVTRYYGLENMESI EQAISMIQTFAALYQEKRGIRWGIERRDTKELIGTIGFHALAQKHRRAEIGYEIIPEH WRNGFASEVISKVVSYGFSALGLSRIGAVVFTDNEASNRLLLKMGFQKEGVLRQYMYQ NGTPYDTNVYSIVKPRE*" gene 2020611..2021144 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" S_feature 2021145..2021230 /Source="Nicolas_S_feature" /locus_tag="new_2021145_2021230" /HighExp="Salt, Sw, B60, LoTm, B36, M9-stat, BC, Lbstat, HiTm, Etha" /AntisenseName="yoaB" /AntisenseCor="-0.17521117067018899" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S686" downshifts 2021187 /Source="Nicolas_upshifts" /id="D1015" /incds=0 /nref=6 /ntot=100 /MaxReadThrough="4.32682" /MaxDrop="3.67936" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin=4 /isTUend="TRUE" CDS complement(2021223..2022467) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12193636, 15849754, 16513748, 16850406, 28546427; Product type t : transporter" /codon_start=1 /transl_table=11 /product="negatively charged metabolite transporter" /protein_id="NP_389736.1" /db_xref="EnsemblGenomes-Gn:BSU18540" /db_xref="EnsemblGenomes-Tr:CAB13747" /db_xref="GOA:O34864" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13473" /db_xref="UniProtKB/Swiss-Prot:O34864" /translation="MLDKIGIPKRLAWGFLGVVLFMMGDGLEQGWLSPFLIENGLTVQ QSASIFSIYGIALAIASWFSGVCLEAFGAKRTMFMGLLFYVIGTAAFIVFGFEQLNLP VMYVTYFVKGLGYPLFAYSFLTWVIYRTPQSKLSTAVGWFWIAYCLGMFVFGAWYSSY AIKAFGYLNTLWSSIFWVCLGAFFALFINKDRFEKKKRKRSETAEELLKGVTILFTNP RVLTGGIIRIINSIGTYGFPVFLPMHMAQHGISTNVWLQIWGTIFLGNIVFNLIFGIV GDKFGWKNTVIWFGGVGCGIFTVLLYYAPVFSGGSLAVVSVIGFIWGGLLAGYVPIGA IVPTVAGKDKGAAMSVLNLAAGLSAFVGPALAWLFIGLVGAQGVVWIFAALYLASAVL TKCIHIPEEKAVKEETSPQYAS*" gene complement(2021223..2022467) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" S_feature 2021232..2021971 /Source="Nicolas_S_feature" /locus_tag="new_2021232_2021971" /HighExp="LoTm, Salt, Sw, S6, Etha, M9-stat, LPhT, B60, T2.0H, T2.30H" /AntisenseName="yoaB" /AntisenseCor="-0.18536963552729299" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S687" downshifts complement(2021237) /Source="Nicolas_upshifts" /id="D1016" /incds=0 /nref=32 /ntot=113 /MaxReadThrough="2.59019" /MaxDrop="4.97477" /score="29.0246554" /energy="-12.5" /TU="NA" /idTUdmin="U1504" /TUdmin=0 /isTUend="TRUE" S_feature complement(2022468..2022560) /Source="Nicolas_S_feature" /locus_tag="new_2022468_2022560_c" /HighExp="MG 10, MG 5, BMM, MG t5, MG 15, GM 25, HiTm, UNK1, GM 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S688" CDS complement(2022561..2024024) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10094622, 12193636, 16850406, 18039762, 21749987, 27795321, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxylated metabolite kinase" /protein_id="NP_389737.1" /db_xref="EnsemblGenomes-Gn:BSU18550" /db_xref="EnsemblGenomes-Tr:CAB13748" /db_xref="GOA:O34861" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG13474" /db_xref="UniProtKB/Swiss-Prot:O34861" /translation="MKKQKGYLVFDIGTGNARVAVVSVTGSVLTVEREDIEYSTETLY PDSRYFSPQVLWKQVMNLAKRALSRSCDIDIIGLTSTSQRQGIVLIDQNGNPFLGLPN IDNRGREWEAGIPDWEEIYSSTGRLPTALFSALKLYGLKQRQPSLWEKTASFTSISDW VTYQLSGILTYEPSQATETLLFDVKQNTWSEEMCDIFGFSPSILPPLVRAGTAIGTIA NEYASELGLSINAKVIAGGGDTQLAVKSTGAGLEDIVIVSGTTTPITKITEDHGDTKH KAWLNCHTDQGHWLVETNPGITGLNYQKLKQIFYPNETYEVMEEEISALAKEDHACVA ALGSYLSAEKNALTRGGFLFDAPLSAHLKRAHFVRAALEEIAFSIKWNFDILTEVTPF ERDYVWVCGGGFQSKALTQYIADLLQKKVYVQEGYHQASVVGAAVICNETFQLTEEMS ANVRVIEPKDCQIELALYEEWKQTQRFFSGSESKVLI*" gene complement(2022561..2024024) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" CDS complement(2024042..2025076) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10094622, 11390694, 12193636, 17012385, 18039762, 21749987, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-hydroxyacid dehydrogenase" /protein_id="NP_389738.1" /db_xref="EnsemblGenomes-Gn:BSU18560" /db_xref="EnsemblGenomes-Tr:CAB13749" /db_xref="GOA:O34815" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13475" /db_xref="UniProtKB/Swiss-Prot:O34815" /translation="MKNTMKRMFCSMTVLVTAPYNEEGRKELENLFGSVAYQSWKEQG RAYREDELIQLLKATNATGLITELDQVTDSVFASVPELSFVGVCRGMPSNVDVAAASK RGIPVFYTPGRNAQAVAEMFIGNVISFLRHTSASNQWLKDGEWDSDYLQAYVKFKGNE LTGKTVGMIGFGAVGQRIAKLLTAFDCKIKYYDPYIQDDHPLYEKASLKTVFSDSDIV SVHLPRTEETLGLIDRQYFDLMKESAIFVNTSRAVVVNREDLLFVLKEHKISGAILDV FYHEPPEESDYELISLPNVLATPHLAGATFEVEDHHVTILNKALKKWKGEKTLNIQTM YNKDALKTGG*" gene complement(2024042..2025076) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" S_feature complement(2025088..2025159) /Source="Nicolas_S_feature" /locus_tag="new_2025088_2025159_c" /HighExp="MG t5, MG 5, MG 10, BMM, GM 25, MG 15, Heat, GM 15, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S689" downshifts complement(2025131) /Source="Nicolas_upshifts" /id="D1017" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="7.78218" /MaxDrop="4.81701" /score="26.3160061" /energy="-11.4" /TU="U1504" /idTUdmin="U1507" /TUdmin=2727 /isTUend="FALSE" misc_RNA complement(2025160..2025251) /gene="mswF" /locus_tag="BSU_misc_RNA_31" /product="AdoMet riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" gene complement(2025160..2025251) /gene="mswF" /locus_tag="BSU_misc_RNA_31" promotor_-10 complement(2025279..2025298) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2025291) /Source="Nicolas_upshifts" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" promotor_-35 complement(2025313..2025320) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2025333..2025340 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2025354..2025373 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2025358 /Source="Nicolas_upshifts" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" CDS 2025400..2027442 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170332, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin cofactor oxido-reductase" /protein_id="NP_389739.2" /db_xref="EnsemblGenomes-Gn:BSU18570" /db_xref="EnsemblGenomes-Tr:CAB13750" /db_xref="GOA:C0SP82" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG13476" /db_xref="UniProtKB/Swiss-Prot:C0SP82" /translation="MRSFATQQNGIFKSVCSLDCPDQCGLLIHKKDGKIVKVQGDPDH PVTAGNICNKVRNMTERIYDEKRLTTPLKRTGAKGQAIFEPISWKEAIDTITSRWKQL IDEEGAESILPYSFYGNMGKLTAEGMDRRFFYRMGSSQLERTICSKAGSEGYKYTMGI SAGIDPEETVHTKLFIFWGINAVSTNMHQITIAQKARKKGAKIVVIDVHKNQTGRLAD WFIPIKPGTDSALALGIMHILFKENLHDEAFLSEYTVGYEELREHVKQYDPEKVSTIT GVSTEDIYRLAKMYGETSPSFIRIGNGPQHHDNGGMIVRTIACLPAITGQWLHTGGGA IKHNSGILEYNTNALQRPDLLKGRTPRSFNMNQLGRVLLETDPPIRSLFIYGTNPAVV APEANKVRQGLLREDLFTVVHDLFLTETAAYADIVLPATSAFENTDFYTSYWHHYIQL QQPVIERYGESKSNTEVFRLLAEAMGFTDQELKDSDEVLIRQALDHPDNPHLAEIDYD SLTKHSFMKAKREKPLFPGELPTPSGKIELYSEKMKQDGFPALPTYTPLVTDNEHPFM YVPGPNHNFLNSTFSNNEKHIKLEKTPKLFINTKDAEKHGIVDGAPVRIWNSRGECEL TAAVGEQVLPGVVVSQGLWADEQGKKQLVNALTPDRLSDMGGGATFFSGRVQIEKV*" gene 2025400..2027442 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" promotor_-35 2027450..2027459 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2027472..2027487 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2027475 /Source="Nicolas_upshifts" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" CDS 2027509..2027802 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389740.1" /db_xref="EnsemblGenomes-Gn:BSU18580" /db_xref="EnsemblGenomes-Tr:CAB13751" /db_xref="SubtiList:BG13477" /db_xref="UniProtKB/Swiss-Prot:O31829" /translation="MDVFLGIGIALAGYFIGEGLKQRNQTKGNEQNDIFLIKERDIYF YIGLFLGITTTEAKQLAGDMADLPYIEINGKKYVQKHMLKDWTFTLVEKHQGE*" gene 2027509..2027802 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" downshifts 2027782 /Source="Nicolas_upshifts" /id="D1018" /incds=0 /nref=97 /ntot=243 /MaxReadThrough="3.40762" /MaxDrop="4.1662" /score="-6.27063114" /energy="-3.9" /TU="U1506" /idTUdmin="U1505" /TUdmin=0 /isTUend="TRUE" S_feature complement(2027827..2028174) /Source="Nicolas_S_feature" /locus_tag="new_2027827_2028174_c" /HighExp="T0.30H, S0, T1.0H, aero, Etha, S8, SMMPr, T-0.40H, ferm, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S690" downshifts complement(2027858) /Source="Nicolas_upshifts" /id="D1019" /incds=0 /nref=43 /ntot=202 /MaxReadThrough="2.3171" /MaxDrop="4.25059" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1507" /TUdmin=0 /isTUend="TRUE" CDS complement(2028175..2028579) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 15849754, 16850406, 20011599, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative phage-related membrane protein" /protein_id="NP_389741.1" /db_xref="EnsemblGenomes-Gn:BSU18590" /db_xref="EnsemblGenomes-Tr:CAB13752" /db_xref="GOA:O31830" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG13478" /db_xref="UniProtKB/Swiss-Prot:O31830" /translation="MKKIASYYLMTLGLSSLTFGLLLGFYSFVMYGDMIIALFTAAIA LLYGFVVYGLFAVPLQMKLQKKARTFNVMYLLIYSVVAFIAAFLFFVINEPASIAWTL QSYFYYMLSIAAAVIYWLWDSLILYKRTASGV*" gene complement(2028175..2028579) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" S_feature complement(2028580..2028675) /Source="Nicolas_S_feature" /locus_tag="new_2028580_2028675_c" /HighExp="T0.30H, T1.0H, T0.0H, T-0.40H, S0, T-1.10H, T-1.40H, SMMPr, Salt, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S691" promotor_-10 complement(2028665..2028680) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2028665..2028784) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513962.1" /translation="MHFFHSRFGQSGEAFSASVLSNKRTSFLKPFISALRIAR*" gene complement(2028665..2028784) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" upshifts complement(2028675) /Source="Nicolas_upshifts" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" promotor_-35 complement(2028693..2028702) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2028780..2028786 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2028800..2028811 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2028811..2029019 /Source="Nicolas_S_feature" /locus_tag="new_2028811_2029019" /HighExp="S5, S8, S7, S6, S4, ferm, BT, nit, T5.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99998799999999999" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S692" upshifts 2028811 /Source="Nicolas_upshifts" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" CDS 2028854..2028976 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513963.1" /db_xref="EnsemblGenomes-Gn:BSU18596" /db_xref="EnsemblGenomes-Tr:CCQ48597" /db_xref="UniProtKB/TrEMBL:L8E9J0" /translation="MSKKGIQNSSIEQIRNDHETETAFKADDPKKHGSDPKRTK*" gene 2028854..2028976 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" CDS 2029020..2029313 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="YP_054581.1" /db_xref="EnsemblGenomes-Gn:BSU18600" /db_xref="EnsemblGenomes-Tr:CAE01456" /db_xref="InterPro:IPR025100" /db_xref="SubtiList:BG14189" /db_xref="UniProtKB/Swiss-Prot:Q7WY68" /translation="MTQKNGADRPDDYKRFSSLDKEYDFQQSIRSNTETESVNTETQT HNKENKNDTTDVAGKYFEPSDYKGSTQLEKGLAETHEQVSDDYFEGTIDQNLD*" gene 2029020..2029313 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" S_feature 2029314..2029407 /Source="Nicolas_S_feature" /locus_tag="new_2029314_2029407" /HighExp="S5, S8, S6, S7, S4, BT, ferm, nit, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S693" downshifts 2029364 /Source="Nicolas_upshifts" /id="D1020" /incds=0 /nref=14 /ntot=74 /MaxReadThrough="3.32407" /MaxDrop="3.87581" /score="-6.27063114" /energy="-3.9" /TU="U1508" /idTUdmin="U1506" /TUdmin="-2" /isTUend="TRUE" CDS complement(2029429..2031114) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting chemotaxis protein" /protein_id="NP_389742.2" /db_xref="EnsemblGenomes-Gn:BSU18610" /db_xref="EnsemblGenomes-Tr:CAB13753" /db_xref="GOA:C0SP89" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR007891" /db_xref="SubtiList:BG13479" /db_xref="UniProtKB/Swiss-Prot:C0SP89" /translation="MKVKTKLLGIISILVVSIIGIGGSSVFMISSTVKKNEELKDKME FQKEIKHIQYELTGLSNDERGFLITRDKEYDEGMKGKADDVLKSLDRVNDLIDEEKYQ SNIEDIKTSFTQYRALNQQVVTAYSSNPKKAETIHFGEERTIRKEGVAPAVNKLSDRL DQEVEDLKDEIQGNGKMSQSLIIIVTGISVILGIVLSIMLLKSIMVPLRSINKQLEEI AHGEADLTKKVIVKNKDEFGQLAQSFNSFTHSLTQIVKQISSSSEQVAASSEELSASA EESKSTSEHISRAMQMAADSNVKQSSMTEKSAESITELLDSISSVASNTGNIADLSSS MRDKAEIGSKSVNKMLDQMKFIDKSVDSAGNGLQTLVASTAEISDISSLITTISEQTN LLALNAAIEAARAGEQGKGFAVVAEEVRKLADETNKSANHIQSVVATIQNESIETVNN IKVVQENVSSGIVLSQETTGNFNEILNLVEQVTSQIQEVAAATQQLTSGVEVIQHTVH TLAAGTKETSANTEAVANSSQEQLHSMGEISYAAESLSQLAEELQTVINRFKY*" gene complement(2029429..2031114) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" downshifts complement(2029441) /Source="Nicolas_upshifts" /id="D1021" /incds=0 /nref=68 /ntot=193 /MaxReadThrough="2.22411" /MaxDrop="4.20676" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1509" /TUdmin="-21" /isTUend="TRUE" S_feature complement(2031115..2031202) /Source="Nicolas_S_feature" /locus_tag="new_2031115_2031202_c" /HighExp="Cold, C30, LBGstat, GM 90, GM 15, GM 45, GM 25, GM 60, GM 10, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115923" /TUshortSig="SigD" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S694" promotor_-10 complement(2031194..2031212) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2031202) /Source="Nicolas_upshifts" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" promotor_-35 complement(2031226..2031233) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2031371..2031380 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2031390 /Source="Nicolas_upshifts" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" promotor_-10 2031393..2031412 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2031439..2032890 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" /EC_number="1.14.14.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 4-hydroxyphenylacetate-3-hydroxylase" /protein_id="NP_389743.2" /db_xref="EnsemblGenomes-Gn:BSU18620" /db_xref="EnsemblGenomes-Tr:CAB13754" /db_xref="GOA:C0SPC0" /db_xref="InterPro:IPR004925" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR012687" /db_xref="InterPro:IPR024674" /db_xref="InterPro:IPR024719" /db_xref="InterPro:IPR036250" /db_xref="SubtiList:BG13480" /db_xref="UniProtKB/Swiss-Prot:C0SPC0" /translation="MGIINGKEFIDRLNKLENEIWYDGEKIKGNISEHPAFKGIIKTK SSLYELQTKDELIHEMTYCLPGDHNRIGLSYLQPKTKNDLKKRRTMIEHWARHTHGMM GRSPDYMNTVMMSFASSAELLKDKENCFPEHILDMYEQAAKHDLSFTHTFITPQVNRS QSYFGLSEKPISAKVIDRTEKGLMIHGARLLATQGGLTDEILVFSAPKFFFETDEAYA FSIPSNTKGVKFITRESFVLSDSSFNHPLSSRYEEMDSIVVFDHVLVPWNRVFFYDNV EAAKDFMTKSSFHAFTFHQVVIRQMIKIEFLLGVAQLLVDTINVSEYQHIQEKLSEII VGLETIKALIDKSENDAQLDEFGYMRPCLIPLQVISTIIPKLYPRFTEIIQLIGASGM VTLPTENAFDSEIREDLDQYLQATNTNAEERVKIFRLAWDLTMSSFGTRQTHYERYFF GDPIRISSRLYTSYPKQEQLNMIKTFLHADTEH*" gene 2031439..2032890 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" downshifts 2032866 /Source="Nicolas_upshifts" /id="D1022" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="2.84304" /MaxDrop="2.93575" /score="2.7297367" /energy="-12" /TU="U1510" /idTUdmin="U1510" /TUdmin="-22" /isTUend="TRUE" CDS complement(2032927..2033625) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 18971341, 26751268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 18971341, 26751268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular endoglucanase precursor (expansin)" /protein_id="NP_389744.1" /db_xref="EnsemblGenomes-Gn:BSU18630" /db_xref="EnsemblGenomes-Tr:CAB13755" /db_xref="GOA:O34918" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036749" /db_xref="InterPro:IPR036908" /db_xref="PDB:2BH0" /db_xref="PDB:3D30" /db_xref="PDB:4FER" /db_xref="PDB:4FFT" /db_xref="PDB:4FG2" /db_xref="PDB:4FG4" /db_xref="SubtiList:BG13481" /db_xref="UniProtKB/Swiss-Prot:O34918" /translation="MKKIMSAFVGMVLLTIFCFSPQASAAYDDLHEGYATYTGSGYSG GAFLLDPIPSDMEITAINPADLNYGGVKAALAGSYLEVEGPKGKTTVYVTDLYPEGAR GALDLSPNAFRKIGNMKDGKINIKWRVVKAPITGNFTYRIKEGSSRWWAAIQVRNHKY PVMKMEYEKDGKWINMEKMDYNHFVSTNLGTGSLKVRMTDIRGKVVKDTIPKLPESGT SKAYTVPGHVQFPE*" gene complement(2032927..2033625) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" downshifts complement(2032942) /Source="Nicolas_upshifts" /id="D1023" /incds=0 /nref=6 /ntot=95 /MaxReadThrough="0.66874" /MaxDrop="3.60414" /score="1.1918692" /energy="-7.7" /TU="NA" /idTUdmin="U1511" /TUdmin=132 /isTUend="FALSE" promotor_-10 complement(2033660..2033679) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2033679) /Source="Nicolas_upshifts" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" S_feature complement(2033681..2033894) /Source="Nicolas_S_feature" /locus_tag="new_2033681_2033894_c" /HighExp="G135, H2O2, G150, G180, LBGstat, dia15, LBGtran, Paraq, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S695" promotor_-35 complement(2033693..2033700) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2033895..2034572) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_389745.1" /db_xref="EnsemblGenomes-Gn:BSU18640" /db_xref="EnsemblGenomes-Tr:CAB13756" /db_xref="GOA:O34343" /db_xref="InterPro:IPR010699" /db_xref="SubtiList:BG13482" /db_xref="UniProtKB/Swiss-Prot:O34343" /translation="MTAAAYRNTLLSLLCLTAGIVDVIGYLSLGHVFTANMTGNIVLL GLAIGKSIQVTVFNSLTALIGFICGVIIATLMVGKAENTLWPSAVTKALALEAFILFV FACLSFYRAFVPVHILIILMSISMGIQTTAAKKLGIAGISSTVLTGTLASLLEDISGR LFFKKQKKTFLRDTVLRALAIILYCVGAIIVALAEPDFYHFIIWVPIVLIFGIMMTAK LKLSGEK*" gene complement(2033895..2034572) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" S_feature complement(2034573..2037062) /Source="Nicolas_S_feature" /locus_tag="new_2034573_2037062_c" /HighExp="LBGstat, G135, H2O2, G180, LBGtran, G150, dia15, Paraq, S0, Diami" /AntisenseName="pelB" /AntisenseCor="0.19898265589133701" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S696" CDS 2034745..2035782 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" /EC_number="4.2.2.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1731776, 2018526, 2185758, 7764549, 22695924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-pectin lyase" /protein_id="NP_389746.1" /db_xref="EnsemblGenomes-Gn:BSU18650" /db_xref="EnsemblGenomes-Tr:CAB13757" /db_xref="GOA:O34819" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12643" /db_xref="UniProtKB/Swiss-Prot:O34819" /translation="MKRLCLWFTVFSLFLVLLPGKALGAVDFPNTSTNGLLGFAGNAK NEKGISKTGTTGGKNGQIVYIQSVNDLKTHLGGSTPKILVLQNDLSASAKTTVTIGSN KTLVGSYAKKTLKNIYLTTSSAFGNVIFQNLTFEHSPQINGNNDIQLYLDSGMNYWID HVTFSGHSYNASGSDLDKLVYIGKSADYITISNSKFANHKYGLILGYPDDSQHQYDGY PHMTIANNYFENLYVRGPGLMRYGYFHVKNNYSNNFNQAITIATKAKIYSEYNYFGKG SEKGGILDDKGTGYFKDIGSYPSLNKQTSPLTSWNPGSNYSYRVQTPEYTKEFVTKYA GSQSTTLVFGY*" gene 2034745..2035782 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" promotor_-35 2035979..2035985 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2036000..2036011 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2036012 /Source="Nicolas_upshifts" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" CDS 2036039..2036722 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23945014, 26070154; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative SOS response associated protein; defective prophage 6" /protein_id="NP_389747.1" /db_xref="EnsemblGenomes-Gn:BSU18660" /db_xref="EnsemblGenomes-Tr:CAB13758" /db_xref="GOA:O34906" /db_xref="InterPro:IPR003738" /db_xref="InterPro:IPR036590" /db_xref="SubtiList:BG13483" /db_xref="UniProtKB/Swiss-Prot:O34906" /translation="MCGRFTLYSAFDDIIDQFDIDQFFPKGEYQPSYNVAPSQNILAI INDGSNNRLGKLRWGLIPPWAKDEKIGYKMINARAETITEKPAFRRPLVSKRCIIPAD SFYEWKRLDSKTKIPMRIKLKSSALFAFAGLYEKWSTHQGYPLYTCTIITTEPNEFMK DIHDRMPVILAHDHEKEWLNPKNTSPDYLQSLLLPYDADDMEAYQVSSLVNSPKNNSA ELLDAENHM*" gene 2036039..2036722 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" CDS complement(2037063..2037368) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative permease, phage-related; defective prophage 6" /protein_id="YP_003097734.1" /db_xref="EnsemblGenomes-Gn:BSU18669" /db_xref="EnsemblGenomes-Tr:CAX52628" /db_xref="GOA:C0H420" /db_xref="UniProtKB/Swiss-Prot:C0H420" /translation="MKALIFLSSLTAIGSSILGRWLGMLDDSYAVGDAWFIGVLAGLI SLLILIDSQTMTKNYIVSLSTILGILGVGFIYFPAAFINILLSITLDKQKKEDLHVR* " gene complement(2037063..2037368) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" S_feature complement(2037369..2037470) /Source="Nicolas_S_feature" /locus_tag="new_2037369_2037470_c" /HighExp="HiTm, LBGstat, LBGtran, T1.30H, T1.0H, T0.30H, M9-stat, Lbstat, M0t90, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S697" promotor_-10 complement(2037449..2037468) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2037470) /Source="Nicolas_upshifts" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" promotor_-35 complement(2037483..2037490) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2037498..2037600) /Source="Nicolas_S_feature" /locus_tag="new_2037498_2037600_c" /HighExp="S8, S6, S7, S5, BT, G/S, Pyr, B36, nit, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S698" downshifts complement(2037540) /Source="Nicolas_upshifts" /id="D1024" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="1.67639" /MaxDrop="3.95763" /score="-5.39979801" /energy="-8.3" /TU="NA" /idTUdmin="U1514" /TUdmin=0 /isTUend="TRUE" CDS complement(2037601..2038779) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11546787, 14697267, 14973022, 15628860, 25526893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11546787, 14697267, 14973022, 15628860, 25526893; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase (Mn2+-dependent); spore constituent" /protein_id="NP_389748.1" /db_xref="EnsemblGenomes-Gn:BSU18670" /db_xref="EnsemblGenomes-Tr:CAB13759" /db_xref="GOA:O34767" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="SubtiList:BG13484" /db_xref="UniProtKB/Swiss-Prot:O34767" /translation="MLLEQQPINHEDRNVPQPIRSDGAGAIDTGPRNIIRDIQNPNIF VPPVTDEGMIPNLRFSFSDAPMKLDHGGWSREITVRQLPISTAIAGVNMSLTAGGVRE LHWHKQAEWAYMLLGRARITAVDQDGRNFIADVGPGDLWYFPAGIPHSIQGLEHCEFL LVFDDGNFSEFSTLTISDWLAHTPKDVLSANFGVPENAFNSLPSEQVYIYQGNVPGSV ASEDIQSPYGKVPMTFKHELLNQPPIQMPGGSVRIVDSSNFPISKTIAAALVQIEPGA MRELHWHPNSDEWQYYLTGQGRMTVFIGNGTARTFDYRAGDVGYVPSNAGHYIQNTGT ETLWFLEMFKSNRYADVSLNQWMALTPKELVQSNLNAGSVMLDSLRKKKVPVVKYPGT *" gene complement(2037601..2038779) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" promotor_-10 complement(2038805..2038824) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2038824) /Source="Nicolas_upshifts" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" promotor_-35 complement(2038838..2038847) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2038902..2039390) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389749.1" /db_xref="EnsemblGenomes-Gn:BSU18680" /db_xref="EnsemblGenomes-Tr:CAB13760" /db_xref="InterPro:IPR032545" /db_xref="SubtiList:BG13485" /db_xref="UniProtKB/Swiss-Prot:O34985" /translation="MRKKNNIKKWLLIIAGFLIICIITLFVMVSGNKVKYEGSGKSGL WMSNLEKSDKTSIGPNYFLNLYWQGSKKEEKWTVVERITLYVDGEKYQDDNVDEYDLS EYTGDEMPGGGRMEDHISTFDYMPEDEVIGHDVLVKVEWRTGQKKQTEAIKLHKKPWY KK*" gene complement(2038902..2039390) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" downshifts complement(2038927) /Source="Nicolas_upshifts" /id="D1025" /incds=0 /nref=32 /ntot=201 /MaxReadThrough="0.50319" /MaxDrop="3.84714" /score="18.561323" /energy="-9.2" /TU="NA" /idTUdmin="U1514" /TUdmin="-1387" /isTUend="FALSE" CDS complement(2039415..2039570) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513964.1" /translation="MKQKMHLRAVIRFNLVFRKHFNLSQKFRQSSVRSLALSYFLFGN ILIVFSY*" gene complement(2039415..2039570) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" CDS complement(2039610..2040365) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389750.1" /db_xref="EnsemblGenomes-Gn:BSU18690" /db_xref="EnsemblGenomes-Tr:CAB13761" /db_xref="GOA:O34983" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR025685" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13486" /db_xref="UniProtKB/Swiss-Prot:O34983" /translation="MCYIEITKDNIEDNHICCALSTKQYEHAVNEKKRWLKARMDEGL VFYRLHERAKVFIEYLPANEAWVPINAPNFMYINCLWVSGRYKNNGHAKRLLDKCIAD AKACGMDGIIHIAGKKKLPYLSDKHFFEHMGFTLQDEAAPYFQLMALTWNGLADSPAF KSQVKSDSINEKGITIYYTAQCPFAVGMINDLRELTEKKGVQFQSIQLSSKEEAQKSP AIWTTFSVFFDGRFVTHEIMSINKFEKLLNTLA*" gene complement(2039610..2040365) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" promotor_-35 2040618..2040623 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2040639..2040657 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2040654 /Source="Nicolas_upshifts" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" CDS 2040673..2041029 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389751.1" /db_xref="EnsemblGenomes-Gn:BSU18700" /db_xref="EnsemblGenomes-Tr:CAB13762" /db_xref="SubtiList:BG13487" /db_xref="UniProtKB/Swiss-Prot:O31831" /translation="MVEKCYSCLICGYKGLIQNPLYKGEYQKTFDICPCCGFEFGYSE DHDVRLGFIVTPDHLIEAAFQLYRKQWLESGMVIAHPEDIPEELKNGNCLKFEVLLKQ LKKLNLDIENFEISGF*" gene 2040673..2041029 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" CDS complement(2040988..2041227) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (putative phage origin); putative defective prophage 6" /protein_id="YP_003097735.1" /db_xref="EnsemblGenomes-Gn:BSU18709" /db_xref="EnsemblGenomes-Tr:CAX52629" /db_xref="UniProtKB/Swiss-Prot:C0H421" /translation="MTVINDYREEPEEAFWILYPMGVKCLSMITKSLLNTNRDFVTDC AFQLNILLIMTVKPKQVQPVSSLKTANFKIFYVKI*" gene complement(2040988..2041227) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" S_feature 2041030..2041466 /Source="Nicolas_S_feature" /locus_tag="new_2041030_2041466" /HighExp="S8, S7, S4, S5, S6, S3, T5.0H, LoTm, BT, T4.0H" /AntisenseName="yozT" /AntisenseCor="0.93420248567111996" /AntisenseRegPval="-120.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S699" S_feature complement(2041228..2041329) /Source="Nicolas_S_feature" /locus_tag="new_2041228_2041329_c" /HighExp="S8, S7, S6, S5, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S700" CDS complement(2041330..2041827) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389752.2" /db_xref="EnsemblGenomes-Gn:BSU18710" /db_xref="EnsemblGenomes-Tr:CAB13763" /db_xref="SubtiList:BG13753" /db_xref="UniProtKB/Swiss-Prot:O31832" /translation="MKRVLFSVIVFTAVGFTFCQSKAHALTFTVLPITQKTDQWSVKV SEAKNVKEFTRPHKGEYQVYSLEVKNIGEKAATVDVQLYRNDPNSITRFSLFGCPDEN CVKPKEDSKMLAESLNDGSPLKFNHFMLADKASELEVVIIWTQKGQEGRNLKQTFKFT EDGVN*" gene complement(2041330..2041827) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" S_feature complement(2041828..2041927) /Source="Nicolas_S_feature" /locus_tag="new_2041828_2041927_c" /HighExp="S8, S7, S5, S6, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S701" CDS complement(2041928..2042839) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8631706; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor for cell wall maintenance or synthesis" /protein_id="NP_389753.1" /db_xref="EnsemblGenomes-Gn:BSU18720" /db_xref="EnsemblGenomes-Tr:CAB13764" /db_xref="InterPro:IPR007391" /db_xref="SubtiList:BG13488" /db_xref="UniProtKB/Swiss-Prot:O34611" /translation="MIQILITGLFLLAQPSEPQDSLTVTQQGRTIATVNREDFTMPLP GTPMVDYEKYSKFIKQLDQKVYREPINAVLNDHGSIVPGRVGYKLYQQAFMEKFYAYF YGQGPSKIEVPEMNIYPKVDSELLAHISTQQLGQYVTYFNSSNKSRSHNISLSAKAID NHVVFPNETFSFNQVVGMRTRNKGYKSAPIIVKGELSEGVGGGICQVSSTLFNAVDRA GLQIVQRYSHTRSVPYVPPGRDATVSWGGPDFRFQNQYNQPILIRAKRYGGSMIITLY SSDVINSRLRKIPKAPSRIPKEINAEQ*" gene complement(2041928..2042839) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" promotor_-10 complement(2042861..2042872) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2042863) /Source="Nicolas_upshifts" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" promotor_-35 complement(2042887..2042893) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2043123..2043130 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2043139 /Source="Nicolas_upshifts" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" promotor_-10 2043145..2043164 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2043186..2043668 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19493340; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin / antitoxin system" /protein_id="NP_389754.1" /db_xref="EnsemblGenomes-Gn:BSU18730" /db_xref="EnsemblGenomes-Tr:CAB13765" /db_xref="GOA:O31833" /db_xref="InterPro:IPR021354" /db_xref="SubtiList:BG13489" /db_xref="UniProtKB/Swiss-Prot:O31833" /translation="MNRMSTIFLKIALVLIGIPILALCIFLVPKVANYSAELFPNIAY IKYLVFIYLYVTAIPFYFALYQAFKLLSYIDKNKAFSGLSVRALKNIKYCAVTISIFY AAGMPVFYLMAEIDDAPGIIVIGLVIIFASMVIAVFAAVLQKLLKEAIDIKSENDLTV *" gene 2043186..2043668 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" CDS 2043678..2043932 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19493340; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin of a toxin / antitoxin system; putative transcriptional regulator" /protein_id="NP_389755.1" /db_xref="EnsemblGenomes-Gn:BSU18740" /db_xref="EnsemblGenomes-Tr:CAB13766" /db_xref="GOA:O31834" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG13754" /db_xref="UniProtKB/Swiss-Prot:O31834" /translation="MAIIINIDVMLAKRKMSVTELSERVGITMANLSILKNGKAKAIR LSTLEAICKALECQPGDILEYRSDEDTGFVKKKYEGSTEK*" gene 2043678..2043932 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" S_feature 2043933..2044037 /Source="Nicolas_S_feature" /locus_tag="new_2043933_2044037" /HighExp="LoTm, B60, Sw, G135, G180, B36, LBGstat, Cold, LBGtran, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S702" CDS 2044038..2044832 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389756.1" /db_xref="EnsemblGenomes-Gn:BSU18750" /db_xref="EnsemblGenomes-Tr:CAB13767" /db_xref="GOA:O34535" /db_xref="InterPro:IPR008535" /db_xref="SubtiList:BG13490" /db_xref="UniProtKB/Swiss-Prot:O34535" /translation="MRAIKQIVHFGWEQALSCLFPAVIFASLAITQIIPLPFLPRYDW LLIICVLMQLWMVRSGLETRDELKVITLFHLIGLALELFKVHMGSWSYPEEGYSKIFG VPLYSGFMYASVASYLCQAWRRLKVELVKWPSFFAVVPLAAAIYLNFFTHHFSIDIRW WLSGLVIIVFWQTWVTYEVNGARYRMPLALSFILIGFFIWIAENIATFFGAWKYPNQI DTWSLVHLGKVSSWLLLVIVSFLIVASLKQVKEQSPTKAEMDESFS*" gene 2044038..2044832 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" S_feature 2044833..2045843 /Source="Nicolas_S_feature" /locus_tag="new_2044833_2045843" /HighExp="LoTm, Cold, Sw, H2O2, B60, GM 10, S8, dia15, T2.30H, MG 60" /AntisenseName="yoaU" /AntisenseCor="-2.6976304882719598E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S703" CDS complement(2044956..2045828) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_389757.1" /db_xref="EnsemblGenomes-Gn:BSU18760" /db_xref="EnsemblGenomes-Tr:CAB13768" /db_xref="GOA:O34701" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13491" /db_xref="UniProtKB/Swiss-Prot:O34701" /translation="MVMNMNHLHIFVKVGEKLNITEAAKELFISQPAVSKAIKNLESS LQLKLLIRDKHHGLMLTDIGKEILLLARQMKGIESKIYQVANRENKLLNGKVKIGSFP AVSTNIMPQAIAAFRSNYPLIRIELIEGTSDQIKGWVEDRTVDIGIAASPFEPFENQL LCNDYMVAVIPPQRDELKLEKHVDLETYQDDLIFCKGGHEIAMSNAFSQYNIELKENL TVQNAETLINMVKNNLGIGIISNFTLSSVPHQLIKKDIFPRVTRDIGVIAHSFEEITP AAHEFVKVLKAVVI*" gene complement(2044956..2045828) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" CDS 2045929..2046807 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10844694, 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative modified amino acid or TCA compound efflux permease" /protein_id="NP_389758.1" /db_xref="EnsemblGenomes-Gn:BSU18770" /db_xref="EnsemblGenomes-Tr:CAB13769" /db_xref="GOA:O34416" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG13492" /db_xref="UniProtKB/Swiss-Prot:O34416" /translation="MVKVMLGIISVTLIWGYTWVAMKVGIHDIPPLLFSGLRLFIGAV PLFLILFIQRKKLSIQKEHLKSYIIMSLLMGLGYMGILTYGMQFVDSGKTSVLVYTMP IFVTVISHFSLNEKMNVYKTMGLVCGLFGLLFIFGKEMLNIDQSALFGELCVLVAALS WGIANVFSKLQFKHIDIIHMNAWHLMMGAVMLLVFSFIFEAVPSAEWTYQAVWSLLFN GLLSTGFTFVVWFWVLNQIQASKASMALMFVPVLALFFGWLQLHEQITINIILGALLI CCGIFMNTFTFSRRKV*" gene 2045929..2046807 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" S_feature complement(2046920..2046979) /Source="Nicolas_S_feature" /locus_tag="new_2046920_2046979_c" /HighExp="BC, T4.0H, M9-stat, S5, T5.0H, S4, S3, T3.0H, T3.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.167154" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S704" downshifts complement(2046955) /Source="Nicolas_upshifts" /id="D1026" /incds=0 /nref=55 /ntot=175 /MaxReadThrough="1.78313" /MaxDrop="5.17096" /score="15.465237" /energy="-12.3" /TU="NA" /idTUdmin="U1518" /TUdmin=0 /isTUend="TRUE" CDS complement(2046980..2047411) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm forming exported protein" /protein_id="NP_389759.1" /db_xref="EnsemblGenomes-Gn:BSU18780" /db_xref="EnsemblGenomes-Tr:CAB13770" /db_xref="SubtiList:BG13493" /db_xref="UniProtKB/Swiss-Prot:O34541" /translation="MKKMLMLAFTFLLALTIHVGEASAVIVKDEEKVSFTMTENEKWF MKSDDLNSNHWTSHFGYRFTIFDTEGCTINARIMRMTLSGYEITVSEKNFSGDHFDFS ATDRVETMPYKTHYLILTKDPDCGDVKVKGLYGFQFDQPEW*" gene complement(2046980..2047411) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" promotor_-10 complement(2047431..2047450) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2047439) /Source="Nicolas_upshifts" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" S_feature complement(2047441..2047674) /Source="Nicolas_S_feature" /locus_tag="new_2047441_2047674_c" /HighExp="S4, S3, S5, S7, S8, S6, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S705" promotor_-35 complement(2047464..2047470) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2047675..2047693) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2047675..2048307) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16181642; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor of the oxidative stress response" /protein_id="NP_389760.1" /db_xref="EnsemblGenomes-Gn:BSU18790" /db_xref="EnsemblGenomes-Tr:CAB13771" /db_xref="GOA:O34947" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13494" /db_xref="UniProtKB/Swiss-Prot:O34947" /translation="MQTRKVYLYVFHTMSDWEYGYLIAELNSGRYFKQDAASLKVVTV GVNKEMITTLGGLSIKPDISLDECTLGSQDLIILPGGNTWGEDIHQPILKKVGDALKL GTTIAAICGATLGLANEGYLNSRKHTSNDLDYMNMVCPNYKGETFYEKGPAVSDENLV TASGIAPLEFAVEVLKKLDVFAPDTLRSWYKLNKTQKPEYFFELMNTINR*" gene complement(2047675..2048307) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" upshifts complement(2047681) /Source="Nicolas_upshifts" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" promotor_-35 complement(2047709..2047714) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2048445..2048452 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2048467..2048486 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2048471 /Source="Nicolas_upshifts" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" CDS 2048533..2049453 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" /EC_number="3.5.2.6" /function="16.5: Explore" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7789815, 15187182, 16944130, 22211522, 25112476, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-lactamase precursor (putative hydrolase)" /protein_id="NP_389761.1" /db_xref="EnsemblGenomes-Gn:BSU18800" /db_xref="EnsemblGenomes-Tr:CAB13772" /db_xref="GOA:P39824" /db_xref="InterPro:IPR000871" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023650" /db_xref="SubtiList:BG11016" /db_xref="UniProtKB/Swiss-Prot:P39824" /translation="MKLKTKASIKFGICVGLLCLSITGFTPFFNSTHAEAKSIEDTNM ASCITNKKFVQLEKKFDARLGVYAIDIGSNKTIAYRPNERFAYASTYKVLAAAAVLKK NSIEKLNEVIHYSKDDLVTYSPITEKHLDTGMSLKEISEAAIRYSDNTAGNILLQQLG GPKGFEKSLKQIGDHVTKAKRFETDLNSAIPGDIRDTSTAKALATDLKAFTLDNTLTT DKRMILTDWMRGNATGDELIRAGAPIGWEVGDKSGAGSYGTRNDIAIVWPPNRAPIVV AILSNRFTKDANYDNALIAEAAKVVLNDLK*" gene 2048533..2049453 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" promotor_-10 complement(2048964..2048983) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2048979) /Source="Nicolas_upshifts" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2048998..2049005) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2049454..2050111 /Source="Nicolas_S_feature" /locus_tag="new_2049454_2050111" /HighExp="HiOs, S8, GM 25, GM 15, GM-0.1, C30, S2, S1, BC, GM 45" /AntisenseName="yobA" /AntisenseCor="8.9918765131424994E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S706" CDS complement(2049950..2050312) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389762.1" /db_xref="EnsemblGenomes-Gn:BSU18810" /db_xref="EnsemblGenomes-Tr:CAB13773" /db_xref="InterPro:IPR021598" /db_xref="PDB:2JQO" /db_xref="PDB:4QY7" /db_xref="SubtiList:BG13495" /db_xref="UniProtKB/Swiss-Prot:O31835" /translation="MPKIGVSLIVLIMLIIFLAGCNKNEQNGDETKMQSLVGYVVLKD NERAILITDTKAPGKEDYNLSEGQLMNKFKNNIVIVGLSEIDNTDDLKRGEKIKVWFH TRKESNPPSATIQKYELL*" gene complement(2049950..2050312) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" CDS complement(2050373..2050585) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type h : extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative phage protein" /db_xref="PSEUDO:CAX52630.1" /translation="MEVAIVNDSKDKYIYAGIQKEAAFNNIFESAKMSKRIISRATTC KYLRKNKKKVEELENEYAAVMNCKKK*" gene complement(2050373..2050585) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /pseudo promotor_-35 2050624..2050631 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2050646..2050665 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2050649 /Source="Nicolas_upshifts" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" CDS 2050689..2050952 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376821; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator from bacteriophage; putative defective prophage 6" /protein_id="NP_389763.1" /db_xref="EnsemblGenomes-Gn:BSU18820" /db_xref="EnsemblGenomes-Tr:CAB13774" /db_xref="SubtiList:BG13496" /db_xref="UniProtKB/Swiss-Prot:O31836" /translation="MKIRKILLSSALSFGMLISAVPALAAGTSSEVAVKNEEYDYDTI YRISPLPMDFQPTIEYNGYTYTLTRHYFDYSIGFYTAIYTKVV*" gene 2050689..2050952 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" downshifts 2050930 /Source="Nicolas_upshifts" /id="D1027" /incds=0 /nref=23 /ntot=100 /MaxReadThrough="0.60454" /MaxDrop="4.81085" /score="19.5390064" /energy="-8.7" /TU="NA" /idTUdmin="U1522" /TUdmin=3 /isTUend="TRUE" CDS complement(2051329..2053929) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" /EC_number="2.7.9.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PEP-dependent enzyme" /protein_id="NP_389764.1" /db_xref="EnsemblGenomes-Gn:BSU18830" /db_xref="EnsemblGenomes-Tr:CAB13775" /db_xref="GOA:O34309" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG12657" /db_xref="UniProtKB/Swiss-Prot:O34309" /translation="MSSLVLGLHEIEKTQLSLVGGKGLHLGELSKIQGIQVPEGFCVT TVGYQKAIEQNETLQVLLDQLTMLKVEDRDQIGNISRKIRQIIMEVDIPSDVVKAVAQ YLSQFGEEHAYAVRSSATAEDLPHASFAGQQDTYLNITGVDAILQHISKCWASLFTDR AVIYRMQNGFDHSQVYLSVIVQRMVFPQASGILFTADPITSNRKVLSIDAGFGLGEAL VSGLVSADCFKVQDGQIIDKRIATKKMAIYGRKEGGTETQQIDSDQQKAQTLTDEQIL QLARIGRQIEAHFGQPQDIEWCLARDTFYIVQSRPITTLFPIPEASDQENHVYISVGH QQMMTDPIKPLGLSFFLLTTVAPMRKAGGRLFVDVTHHLASPDSREVFLKGMGQHDQL LKDALMTIIKRRDFIKSIPNDKTAPNPSRGNADMPAQVENDPTIVSDLIESSQTSIEE LKQNIQTKSGSDLFRFILEDIQELKKILFNPKSSVLIRTAMNASLWINEKMNEWLGEK NAADTLSQSVPHNITSEMGLALLDVADVIRPYPEVIDYLQHVKDDNFLDELAKFDGGS KTRDAIYDYLSKYGMRCTGEIDITRTRWSEKPTTLVPMILNNIKNFEPNVGHRKFEQG RQEALKKEQELLDRLKQLPDGEQKAKETKRAIDIIRNFSGFREYPKYGMVNRYFVYKQ ALLKEAEQLIEAGVIHEKEDIYYLTFEELHEVVRTHKLDYQIISTRKDEYTLYEKLSP PRVITSDGEIVTGEYKRENLPAGAIVGLPVSSGVIEGRARVILNMEDADLEDGDILVT SFTDPSWTPLFVSIKGLVTEVGGLMTHGAVIAREYGLPAVVGVENAAKLIKDGQRIRV HGTEGYIEIF*" gene complement(2051329..2053929) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" S_feature complement(2053930..2054039) /Source="Nicolas_S_feature" /locus_tag="new_2053930_2054039_c" /HighExp="dia15, BC, S6, SMMPr, H2O2, S5, T-5.40H, S4, HPh, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S707" promotor_-35 2053955..2053962 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2053977..2053996 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2053985..2054612 /Source="Nicolas_S_feature" /locus_tag="new_2053985_2054612" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, S1, T2.30H, Heat, S2, T-5.40H, C30" /AntisenseName="xynA" /AntisenseCor="-0.30871986344497798" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S708" upshifts 2053985 /Source="Nicolas_upshifts" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" promotor_-10 complement(2054029..2054048) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2054039) /Source="Nicolas_upshifts" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" promotor_-35 complement(2054063..2054069) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2054085..2054544) /Source="Nicolas_S_feature" /locus_tag="new_2054085_2054544_c" /HighExp="S0, Lbstat, HiTm, dia0, ferm, Lbexp, T1.0H, M0t45, LBGtran, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S709" downshifts complement(2054127) /Source="Nicolas_upshifts" /id="D1028" /incds=0 /nref=87 /ntot=200 /MaxReadThrough="1.89557" /MaxDrop="5.26144" /score="1.97345986" /energy="-10.4" /TU="NA" /idTUdmin="U1525" /TUdmin=0 /isTUend="TRUE" downshifts complement(2054589) /Source="Nicolas_upshifts" /id="D1029" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="5.28207" /MaxDrop="3.16026" /score="1.97345986" /energy="-10.4" /TU="U1525" /idTUdmin="U1525" /TUdmin="-462" /isTUend="FALSE" CDS complement(2054599..2055240) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" /EC_number="3.2.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7704256, 8628241, 16517552, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704256, 8628241, 16517552, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-1,4-beta-xylanase" /protein_id="NP_389765.1" /db_xref="EnsemblGenomes-Gn:BSU18840" /db_xref="EnsemblGenomes-Tr:CAB13776" /db_xref="GOA:P18429" /db_xref="InterPro:IPR001137" /db_xref="InterPro:IPR013319" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018208" /db_xref="InterPro:IPR033119" /db_xref="InterPro:IPR033123" /db_xref="PDB:1AXK" /db_xref="PDB:1XXN" /db_xref="PDB:2B42" /db_xref="PDB:2B45" /db_xref="PDB:2B46" /db_xref="PDB:2DCY" /db_xref="PDB:2DCZ" /db_xref="PDB:2QZ3" /db_xref="PDB:2Z79" /db_xref="PDB:3EXU" /db_xref="PDB:3HD8" /db_xref="PDB:5K9Y" /db_xref="SubtiList:BG10808" /db_xref="UniProtKB/Swiss-Prot:P18429" /translation="MFKFKKNFLVGLSAALMSISLFSATASAASTDYWQNWTDGGGIV NAVNGSGGNYSVNWSNTGNFVVGKGWTTGSPFRTINYNAGVWAPNGNGYLTLYGWTRS PLIEYYVVDSWGTYRPTGTYKGTVKSDGGTYDIYTTTRYNAPSIDGDRTTFTQYWSVR QSKRPTGSNATITFSNHVNAWKSHGMNLGSNWAYQVMATEGYQSSGSSNVTVW*" gene complement(2054599..2055240) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" S_feature complement(2055241..2055358) /Source="Nicolas_S_feature" /locus_tag="new_2055241_2055358_c" /HighExp="S0, HiTm, T1.0H, Gly, Lbstat, SMMPr, Lbtran, LBGstat, SMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S710" promotor_-10 complement(2055335..2055354) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2055358) /Source="Nicolas_upshifts" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" promotor_-35 complement(2055368..2055370) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2055868..2056107) /gene="yozV" /locus_tag="BSU_18849" /old_locus_tag="BSU18849" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; putative defective prophage 6" /protein_id="YP_003097736.1" /db_xref="EnsemblGenomes-Gn:BSU18849" /db_xref="EnsemblGenomes-Tr:CAX52631" /db_xref="GOA:C0H423" /db_xref="InterPro:IPR007829" /db_xref="UniProtKB/Swiss-Prot:C0H423" /translation="MVSKKNKIVAALLAFFFGGLGIHKFYLGRVGQGILYILFCWTGI PSIIAFIEFIIFLCGSEEGFDQKYNFYYFQQQSKA*" gene complement(2055868..2056107) /gene="yozV" /locus_tag="BSU_18849" /old_locus_tag="BSU18849" downshifts complement(2055888) /Source="Nicolas_upshifts" /id="D1030" /incds=0 /nref=31 /ntot=127 /MaxReadThrough="3.22282" /MaxDrop="3.97488" /score="-1.08247697" /energy="-4.5" /TU="U1526" /idTUdmin="U1526" /TUdmin="-529" /isTUend="FALSE" misc_feature complement(2056147..2056166) /Source="Nicolas_upshift_promotors" /id="U1526" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig="0.985014985014985" /xcortree=2315 /SigmaFactorBS="taaaaaatctcaaaagaatttcaaaattttcacgatttctgg cggaaaATGCATTATAATGTGAAAGCattactttaaaaatggtagcaatgaactagga g" /listShort="yozV" /listLong="S710, xynA, S709" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2056154) /Source="Nicolas_upshifts" /id="U1526" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig="0.985014985014985" /xcortree=2315 /SigmaFactorBS="taaaaaatctcaaaagaatttcaaaattttcacgatttctgg cggaaaATGCATTATAATGTGAAAGCattactttaaaaatggtagcaatgaactagga g" /listShort="yozV" /listLong="S710, xynA, S709" promotor_-35 2056213..2056220 /Source="Nicolas_upshift_promotors" /id="U1527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.897102897102897" /psig="0.99100899100899" /xcortree=3063 /SigmaFactorBS="gtgaaaattttgaaattcttttgagatttttTATTTTATtga gaaatgaaagcTCATATAATTGAACTAGATGgttttgggaggcatttattcaaaatgt a" /listShort="yobD, S711, yozI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2056235..2056254 /Source="Nicolas_upshift_promotors" /id="U1527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.897102897102897" /psig="0.99100899100899" /xcortree=3063 /SigmaFactorBS="gtgaaaattttgaaattcttttgagatttttTATTTTATtga gaaatgaaagcTCATATAATTGAACTAGATGgttttgggaggcatttattcaaaatgt a" /listShort="yobD, S711, yozI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2056242 /Source="Nicolas_upshifts" /id="U1527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.897102897102897" /psig="0.99100899100899" /xcortree=3063 /SigmaFactorBS="gtgaaaattttgaaattcttttgagatttttTATTTTATtga gaaatgaaagcTCATATAATTGAACTAGATGgttttgggaggcatttattcaaaatgt a" /listShort="yobD, S711, yozI" /GFF_Attribute="listLong" CDS 2056278..2056616 /gene="yobD" /locus_tag="BSU_18850" /old_locus_tag="BSU18850" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10376821" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376821; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="transcriptional regulator (phage-related, Xre family); putative defective prophage 6" /protein_id="NP_389766.1" /db_xref="EnsemblGenomes-Gn:BSU18850" /db_xref="EnsemblGenomes-Tr:CAB13777" /db_xref="GOA:O34647" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR027910" /db_xref="SubtiList:BG13497" /db_xref="UniProtKB/Swiss-Prot:O34647" /translation="MYCQRLRQLRKAHKLTMEQLAEKIGIAKSSYGGYEAESKKPPLD KLVILARLYDVSVDYILGLTDDPDPKVERKNLKEFLEKPDIHWDGYKLTPEILDPIRK ILKLVTANNN*" gene 2056278..2056616 /gene="yobD" /locus_tag="BSU_18850" /old_locus_tag="BSU18850" S_feature 2056617..2057213 /Source="Nicolas_S_feature" /locus_tag="new_2056617_2057213" /HighExp="M0t90, Lbstat, Lbtran, MG 150, M40t90, MG 15, SMM, GM 25, Fru, GM-0.1" /AntisenseName="yozH" /AntisenseCor="0.41013265801279702" /AntisenseRegPval="-11.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S711" CDS complement(2056650..2057006) /gene="yozH" /locus_tag="BSU_18860" /old_locus_tag="BSU18860" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein; putative defective prophage 6" /protein_id="NP_389767.2" /db_xref="EnsemblGenomes-Gn:BSU18860" /db_xref="EnsemblGenomes-Tr:CAB13778" /db_xref="SubtiList:BG13755" /db_xref="UniProtKB/Swiss-Prot:O31837" /translation="MNDLLFAAGNLHIGLGHDYLKCIALLINVKRFFSLTESYGNISD KLAVVAMKGVQFDQFEEAYKAYKETVAINQNSLVDFLSALITLIKAGEKLQKAGESLA IIMNKLLEMSPENSMK*" gene complement(2056650..2057006) /gene="yozH" /locus_tag="BSU_18860" /old_locus_tag="BSU18860" CDS 2057214..2057579 /gene="yozI" /locus_tag="BSU_18870" /old_locus_tag="BSU18870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative defective prophage 6" /protein_id="NP_389768.1" /db_xref="EnsemblGenomes-Gn:BSU18870" /db_xref="EnsemblGenomes-Tr:CAB13779" /db_xref="SubtiList:BG13756" /db_xref="UniProtKB/Swiss-Prot:O31838" /translation="MPKLYTCLICGYKGLIQNPLNNDGEYQKTFDICPCCDFEYGYSE DHDVSLGFIVTPDYLIDAAIQLYRKQWIENGMKTANPEDIPEELRNGDCLKFEVLLKQ LNSLNLDTENFEIKGFNGY*" gene 2057214..2057579 /gene="yozI" /locus_tag="BSU_18870" /old_locus_tag="BSU18870" S_feature complement(2057588..2058714) /Source="Nicolas_S_feature" /locus_tag="new_2057588_2058714_c" /HighExp="BC, Sw, HiOs, C90, Lbstat, M0t90, UNK1, M9-stat, HiTm, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="SigA" /TUlongPSig="0.994" /label="S712" downshifts complement(2057631) /Source="Nicolas_upshifts" /id="D1031" /incds=0 /nref=3 /ntot=99 /MaxReadThrough="3.80479" /MaxDrop="4.2268" /score="22.3776508" /energy="-7.6" /TU="U1528" /idTUdmin="U1528" /TUdmin="-513" /isTUend="FALSE" CDS 2057801..2058460 /gene="yobE" /locus_tag="BSU_18880" /old_locus_tag="BSU18880" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative SOS response associated phage protein; putative defective prophage 6" /protein_id="NP_389769.1" /db_xref="EnsemblGenomes-Gn:BSU18880" /db_xref="EnsemblGenomes-Tr:CAB13780" /db_xref="GOA:O34915" /db_xref="InterPro:IPR003738" /db_xref="InterPro:IPR036590" /db_xref="SubtiList:BG13498" /db_xref="UniProtKB/Swiss-Prot:O34915" /translation="MCGKFTLFSEFDDIIEQFNIDQFLPEGEYHPSYNVAPSQNILTI INDGSNNRLGKLRWGLIPPCAKDEKIGYKMINARAETLAEKPSFRKPLGSKRCIIPAD SFYEWKRLDPKTKIPMRIKLKSSNLFAFAGLYEKWNTLEGNLLYTCTIITIKPSELME DIHDRMPVILTDENKKEWLNPKNTDPDYLQSLLLPYDADDMEAYQVSSLVNSPELIES H*" gene 2057801..2058460 /gene="yobE" /locus_tag="BSU_18880" /old_locus_tag="BSU18880" downshifts 2058538 /Source="Nicolas_upshifts" /id="D1032" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="1.22982" /MaxDrop="2.96245" /score="5.95470205" /energy="-19.6" /TU="NA" /idTUdmin="U1527" /TUdmin=990 /isTUend="FALSE" CDS complement(2058715..2059638) /gene="yobF" /locus_tag="BSU_18890" /old_locus_tag="BSU18890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389770.1" /db_xref="EnsemblGenomes-Gn:BSU18890" /db_xref="EnsemblGenomes-Tr:CAB13781" /db_xref="SubtiList:BG13499" /db_xref="UniProtKB/Swiss-Prot:O34780" /translation="MLVYIGNGHYCYSNSTAMFLSSIGENVSPQLVEILTGVGLGAMI EYEKNLYFSMRDPDDGINYALNILGFTAEEHQQASDLDDPFPLLKQQIKQNPVILGPL DMGELTYHPNHKNLNGSDHYVLGYQMDNENIYVQDPAGFPFVPLSLDQFKKAWMAERI PYRKGINKYWSTAKKVVTLDNNEIYERAIDYFKRTYRKFEKVDIGLIGREAICFYADQ LLNAPITADTIRHTTFFLFQLSARRANDYAMYFKDRHSHLSVLKTEQAKVFGICHSMS VNKDWKGISEKLMKLADLEDNFRLELLKVGY*" gene complement(2058715..2059638) /gene="yobF" /locus_tag="BSU_18890" /old_locus_tag="BSU18890" promotor_-10 complement(2059494..2059513) /Source="Nicolas_upshift_promotors" /id="U1528" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.746253746253746" /psig="0.997002997002997" /xcortree=3033 /SigmaFactorBS="tctcctcaacttgtagagatattaaCTGGTGTTgggttaggt gcCATGATAGAATATGAAAAAAacctttattttagtatgagagatcctgatgatggta t" /listShort="S712" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2059497) /Source="Nicolas_upshifts" /id="U1528" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.746253746253746" /psig="0.997002997002997" /xcortree=3033 /SigmaFactorBS="tctcctcaacttgtagagatattaaCTGGTGTTgggttaggt gcCATGATAGAATATGAAAAAAacctttattttagtatgagagatcctgatgatggta t" /listShort="S712" /GFF_Attribute="listLong" promotor_-35 complement(2059525..2059532) /Source="Nicolas_upshift_promotors" /id="U1528" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.746253746253746" /psig="0.997002997002997" /xcortree=3033 /SigmaFactorBS="tctcctcaacttgtagagatattaaCTGGTGTTgggttaggt gcCATGATAGAATATGAAAAAAacctttattttagtatgagagatcctgatgatggta t" /listShort="S712" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2059649..2059668) /Source="Nicolas_upshift_promotors" /id="U1529" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.994005994005994" /xcortree=398 /SigmaFactorBS="aaatgatccagatgatgaatacgagaacggagcaatttaaTA TGGATTttcaattttcaaaaTTGTAAGGTTAACTTATCTAcccggaggtgatgttagt g" /listShort="yobF" /listLong="S712" /label="promotor_-10" upshifts complement(2059670) /Source="Nicolas_upshifts" /id="U1529" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.994005994005994" /xcortree=398 /SigmaFactorBS="aaatgatccagatgatgaatacgagaacggagcaatttaaTA TGGATTttcaattttcaaaaTTGTAAGGTTAACTTATCTAcccggaggtgatgttagt g" /listShort="yobF" /listLong="S712" promotor_-35 complement(2059683..2059690) /Source="Nicolas_upshift_promotors" /id="U1529" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.994005994005994" /xcortree=398 /SigmaFactorBS="aaatgatccagatgatgaatacgagaacggagcaatttaaTA TGGATTttcaattttcaaaaTTGTAAGGTTAACTTATCTAcccggaggtgatgttagt g" /listShort="yobF" /listLong="S712" /label="promotor_-35" CDS complement(2059691..2059864) /gene="yozW" /locus_tag="BSU_18898" /old_locus_tag="BSU18898" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein; putative defective prophage 6" /protein_id="YP_003097737.1" /db_xref="EnsemblGenomes-Gn:BSU18898" /db_xref="EnsemblGenomes-Tr:CAX52632" /db_xref="UniProtKB/Swiss-Prot:C0H424" /translation="MTEIKANSTVMIHVLADETLSSIKREYVEVDRKTEIGEKIIIVD KNDPDDEYENGAI*" gene complement(2059691..2059864) /gene="yozW" /locus_tag="BSU_18898" /old_locus_tag="BSU18898" CDS 2060009..2060233 /gene="yozX" /locus_tag="BSU_18899" /old_locus_tag="BSU18899" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; putative defective prophage 6" /protein_id="YP_003097738.1" /db_xref="EnsemblGenomes-Gn:BSU18899" /db_xref="EnsemblGenomes-Tr:CAX52633" /db_xref="UniProtKB/Swiss-Prot:C0H425" /translation="MNFLLDLFTNWTFDKVLDYTLAAVIWSVFKSRSKQNKYPGYFEK IRRYRNLHPLLRSLSMRVLLSITIHPYMFS*" gene 2060009..2060233 /gene="yozX" /locus_tag="BSU_18899" /old_locus_tag="BSU18899" CDS complement(2060237..2060692) /gene="yozJ" /locus_tag="BSU_18900" /old_locus_tag="BSU18900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389771.1" /db_xref="EnsemblGenomes-Gn:BSU18900" /db_xref="EnsemblGenomes-Tr:CAB13782" /db_xref="SubtiList:BG13757" /db_xref="UniProtKB/Swiss-Prot:O31839" /translation="MADRYVLIEVNEDGEGRLKDEAVTWIDFRLSIVDFNASEGLNQL MEQISKDVKDELVLVLFNYRVKSSYDSWSGATEYEDFFDVEFFKVIKKNYKKFYQGLV TVELDVGINGFDNIESMPTDSNQNYYRNLIAEWEEFYNEDFIPLSLNKR*" gene complement(2060237..2060692) /gene="yozJ" /locus_tag="BSU_18900" /old_locus_tag="BSU18900" promotor_-35 2060752..2060759 /Source="Nicolas_upshift_promotors" /id="U1530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig="0.96003996003996" /xcortree=483 /SigmaFactorBS="aaatcacgattttaactatttatgatccattagtCACTTCCA aagcaacttccattTAACTCATAATTAATATATAaaatgtaaatggagttgatatatt t" /listShort="yozY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2060774..2060793 /Source="Nicolas_upshift_promotors" /id="U1530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig="0.96003996003996" /xcortree=483 /SigmaFactorBS="aaatcacgattttaactatttatgatccattagtCACTTCCA aagcaacttccattTAACTCATAATTAATATATAaaatgtaaatggagttgatatatt t" /listShort="yozY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2060778 /Source="Nicolas_upshifts" /id="U1530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig="0.96003996003996" /xcortree=483 /SigmaFactorBS="aaatcacgattttaactatttatgatccattagtCACTTCCA aagcaacttccattTAACTCATAATTAATATATAaaatgtaaatggagttgatatatt t" /listShort="yozY" /GFF_Attribute="listLong" CDS 2060817..2061077 /gene="yozY" /locus_tag="BSU_18908" /old_locus_tag="BSU18908" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator from bacteriophage; putative defective prophage 6" /protein_id="YP_003097739.1" /db_xref="EnsemblGenomes-Gn:BSU18908" /db_xref="EnsemblGenomes-Tr:CAX52634" /db_xref="UniProtKB/Swiss-Prot:C0H426" /translation="MNLRKILLSSALSLGMLVSAAPVLATSSSSEVIVKSDEYDYDTI YQLSPLPNFKPSIEYNGYTYTLTRYYFDYSIQFYTAIYTKVV*" gene 2060817..2061077 /gene="yozY" /locus_tag="BSU_18908" /old_locus_tag="BSU18908" downshifts 2061024 /Source="Nicolas_upshifts" /id="D1033" /incds=0 /nref=1 /ntot=221 /MaxReadThrough="4.57606" /MaxDrop="3.58254" /score="4.613667" /energy="-8.7" /TU="U1530" /idTUdmin="U1530" /TUdmin="-638" /isTUend="FALSE" promotor_-35 2061492..2061495 /Source="Nicolas_upshift_promotors" /id="U1531" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.731268731268731" /xcortree=2853 /SigmaFactorBS="ataagagttattatatagggattacaCTACcattatctgggg gTGTATTAACATCCAAATACTcaaaagcaagaacaaatgtacccatagcacttccatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2061509..2061528 /Source="Nicolas_upshift_promotors" /id="U1531" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.731268731268731" /xcortree=2853 /SigmaFactorBS="ataagagttattatatagggattacaCTACcattatctgggg gTGTATTAACATCCAAATACTcaaaagcaagaacaaatgtacccatagcacttccatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2061526 /Source="Nicolas_upshifts" /id="U1531" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.731268731268731" /xcortree=2853 /SigmaFactorBS="ataagagttattatatagggattacaCTACcattatctgggg gTGTATTAACATCCAAATACTcaaaagcaagaacaaatgtacccatagcacttccatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2061638 /Source="Nicolas_upshifts" /id="D1034" /incds=0 /nref=13 /ntot=69 /MaxReadThrough="3.18248" /MaxDrop="3.66335" /score="32.4789235" /energy="-13.7" /TU="U1530,U1531" /idTUdmin="U1530" /TUdmin="-24" /isTUend="FALSE" CDS 2061855..2061995 /gene="yozZ" /locus_tag="BSU_18909" /old_locus_tag="BSU18909" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative phage holin (fragment)" /db_xref="PSEUDO:CAX52635.1" /translation="MTVFGDDLTEKFNALLTFLTALGIIVDPTTQGISDSEQAMDYDS PR*" gene 2061855..2061995 /gene="yozZ" /locus_tag="BSU_18909" /old_locus_tag="BSU18909" /pseudo downshifts 2061992 /Source="Nicolas_upshifts" /id="D1035" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="2.30104" /MaxDrop="4.04304" /score="32.4789235" /energy="-13.7" /TU="NA" /idTUdmin="U1531" /TUdmin=242 /isTUend="FALSE" promotor_-35 2062077..2062084 /Source="Nicolas_upshift_promotors" /id="U1532" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=2950 /SigmaFactorBS="ttttttcaaatgaaaaaattgcagaaaactttacatccttTT ACAATTttttcaatgacTATGTTATGATTGTTTTCGAgagatttttgaaattttcaga a" /listShort="rapK, phrK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2062096..2062115 /Source="Nicolas_upshift_promotors" /id="U1532" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=2950 /SigmaFactorBS="ttttttcaaatgaaaaaattgcagaaaactttacatccttTT ACAATTttttcaatgacTATGTTATGATTGTTTTCGAgagatttttgaaattttcaga a" /listShort="rapK, phrK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2062097 /Source="Nicolas_upshifts" /id="U1532" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=2950 /SigmaFactorBS="ttttttcaaatgaaaaaattgcagaaaactttacatccttTT ACAATTttttcaatgacTATGTTATGATTGTTTTCGAgagatttttgaaattttcaga a" /listShort="rapK, phrK" /GFF_Attribute="listLong" CDS 2062150..2063265 /gene="rapK" /locus_tag="BSU_18910" /old_locus_tag="BSU18910" /EC_number="3.1.-.-" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:16816200, 25225273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16816200, 25225273; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_389772.1" /db_xref="EnsemblGenomes-Gn:BSU18910" /db_xref="EnsemblGenomes-Tr:CAB13783" /db_xref="GOA:O34930" /db_xref="InterPro:IPR011990" /db_xref="SubtiList:BG12664" /db_xref="UniProtKB/Swiss-Prot:O34930" /translation="MSKIASEVVATTLNDWYIAIKKQKVDESIKYYSEIKKLFDEMEE DQEVLAYYSLLEERHKMLLHSSRGEPLQKHTYFTEDNQNFITKTNDKLEYNFYLFEAM YEAYNKNYDRAINLYGLAEKKLAEIPDEIEAAEFYSKVSYLYTLVKQSIVAQHYIKNA ISIYKRHPDYKCKLATSTMIAAANYADMKRFEEAEQYYLEAIDIAKETKDEFLKAQLF HNLSIVYSDWNKPDKCIESLEKAIGNESWLHSIYYINSLFMMIKELFKIDEKMKAINF YNKAQERLILMENKVYEAKISILYNLYCGELKNNFNNCISNIEFLKQQNELESVDELS YIAAKRFESIGAFEEATSFFNAKIWAEQKMNQVEGIL*" gene 2062150..2063265 /gene="rapK" /locus_tag="BSU_18910" /old_locus_tag="BSU18910" promotor_-35 2062989..2062997 /Source="Nicolas_upshift_promotors" /id="U1533" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=505 /SigmaFactorBS="aaattgacgaaaaaatgaaagccattaatttttacaataaag cACAGGAAAGactcatattaaTGGAGAATAAAGTATACGAagccaaaatcagcatcct g" /listShort="phrK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2063006 /Source="Nicolas_upshifts" /id="U1533" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=505 /SigmaFactorBS="aaattgacgaaaaaatgaaagccattaatttttacaataaag cACAGGAAAGactcatattaaTGGAGAATAAAGTATACGAagccaaaatcagcatcct g" /listShort="phrK" /GFF_Attribute="listLong" promotor_-10 2063009..2063027 /Source="Nicolas_upshift_promotors" /id="U1533" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=505 /SigmaFactorBS="aaattgacgaaaaaatgaaagccattaatttttacaataaag cACAGGAAAGactcatattaaTGGAGAATAAAGTATACGAagccaaaatcagcatcct g" /listShort="phrK" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2063262..2063384 /gene="phrK" /locus_tag="BSU_18920" /old_locus_tag="BSU18920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11587781, 16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11587781, 16816200; Product type r: regulator" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapK" /protein_id="NP_389773.1" /db_xref="EnsemblGenomes-Gn:BSU18920" /db_xref="EnsemblGenomes-Tr:CAB13784" /db_xref="InterPro:IPR030968" /db_xref="SubtiList:BG12646" /db_xref="UniProtKB/Swiss-Prot:O31840" /translation="MKKLVLCVSILAVILSGVALTQLSTDSPSNIQVAERPVGG*" gene 2063262..2063384 /gene="phrK" /locus_tag="BSU_18920" /old_locus_tag="BSU18920" downshifts 2063378 /Source="Nicolas_upshifts" /id="D1036" /incds=0 /nref=232 /ntot=252 /MaxReadThrough="2.33184" /MaxDrop="6.45227" /score="9.89565332" /energy="-10.4" /TU="NA" /idTUdmin="U1532" /TUdmin=0 /isTUend="TRUE" CDS complement(2063510..2064163) /gene="yobHc" /locus_tag="BSU_18930" /old_locus_tag="BSU18930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="fragment of putative DNA phage repair protein; putative defective prophage 6" /db_xref="EnsemblGenomes-Gn:BSU18930" /db_xref="EnsemblGenomes-Tr:CAB13785" /db_xref="GOA:C0SPA8" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR024728" /db_xref="InterPro:IPR036775" /db_xref="PSEUDO:CAB13785.2" /db_xref="SubtiList:BG13500" /db_xref="UniProtKB/Swiss-Prot:C0SPA8" /translation="MAKAIQSSMWREFGLMCTVGIGDNMLLSKLALDLESKKTKSGIA RWRYEDVPNRLWKVRPLSKMWGIGGRMERNLNRMGISTVGQLAKFPLELLEKKFGIMG NQLYYHAHGIDLSEIGAPLMQGQISFGKSQILFRDYTKREEIKAVLLEICEEVARRAR TYNKVGRTISLGIGYSKDELGGGFHRSKTIDFPTNITMDIYKCCLMFFNKFYSGKKQ* " gene complement(2063510..2064163) /gene="yobHc" /locus_tag="BSU_18930" /old_locus_tag="BSU18930" /pseudo downshifts complement(2063784) /Source="Nicolas_upshifts" /id="D1037" /incds=1 /nref=1 /ntot=2 /MaxReadThrough="1.36944" /MaxDrop="2.50062" /score="17.2005818" /energy="-10" /TU="NA" /idTUdmin="U1535" /TUdmin=1628 /isTUend="FALSE" CDS complement(2064200..2064547) /gene="yobHm" /locus_tag="BSU_18940" /old_locus_tag="BSU18940" /function="16.9: Replicate" /function="16.5: Explore" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12137951; Product type h: extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative phage DNA repair protein fragment; putative defective prophage 6" /db_xref="EnsemblGenomes-Gn:BSU18940" /db_xref="EnsemblGenomes-Tr:CAB13786" /db_xref="GOA:O31841" /db_xref="InterPro:IPR001126" /db_xref="PSEUDO:CAB13786.1" /db_xref="SubtiList:BG13758" /db_xref="UniProtKB/Swiss-Prot:O31841" /translation="MTDYSQFPRENILCVDMKSFYASVSAVAMGLNPLTCYLAVVGNT DRQGSVVLAASPALKKDFGIKTGSRLFEIPEDPRIYIVNPQMKLFIRVSTEITKLFYR FVPEKCVHTYSID*" gene complement(2064200..2064547) /gene="yobHm" /locus_tag="BSU_18940" /old_locus_tag="BSU18940" /pseudo CDS complement(2064540..2064833) /gene="yozL" /locus_tag="BSU_18950" /old_locus_tag="BSU18950" /function="16.6: Maintain" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12137951" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein of phage origin; putative defective prophage 6" /protein_id="NP_389776.1" /db_xref="EnsemblGenomes-Gn:BSU18950" /db_xref="EnsemblGenomes-Tr:CAB13787" /db_xref="InterPro:IPR014962" /db_xref="SubtiList:BG13759" /db_xref="UniProtKB/Swiss-Prot:O31842" /translation="MMLEQLIQLKQDLIDGSKVEKPSLDDKQIDEMDILVSEALEFNK ELKFKLFNKGFVENVTGRVHYINFEQQKLHVKDQNDNTVYINMNNIIRVIYND*" gene complement(2064540..2064833) /gene="yozL" /locus_tag="BSU_18950" /old_locus_tag="BSU18950" upshifts 2064984 /Source="Nicolas_upshifts" /id="U1534" /multdbtbs="-" /comp="M1" /sig="SigA" /pcomp="0.340659340659341" /psig="0.65034965034965" /xcortree=472 /SigmaFactorBS="tatagatcagaacaaaagttcgatgtaaatgttggtaataaa atataaaggtcaataatgaTATCCGTAGTATTAATAAAGgagagattcttttcgacga g" /listShort="yozM" /GFF_Attribute="listLong" misc_feature 2064985..2065004 /Source="Nicolas_upshift_promotors" /id="U1534" /multdbtbs="-" /comp="M1" /sig="SigA" /pcomp="0.340659340659341" /psig="0.65034965034965" /xcortree=472 /SigmaFactorBS="tatagatcagaacaaaagttcgatgtaaatgttggtaataaa atataaaggtcaataatgaTATCCGTAGTATTAATAAAGgagagattcttttcgacga g" /listShort="yozM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 2065042..2065377 /gene="yozM" /locus_tag="BSU_18960" /old_locus_tag="BSU18960" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative bacteriophage protein; putative defective prophage 6" /protein_id="NP_389777.1" /db_xref="EnsemblGenomes-Gn:BSU18960" /db_xref="EnsemblGenomes-Tr:CAB13788" /db_xref="SubtiList:BG13760" /db_xref="UniProtKB/Swiss-Prot:O31843" /translation="MKKRLIGFLVLVPALIMWGITLIESNKKTPVEVLESAWDEFGLF SFEIGITDPAITIGMDQTKSEAKLREYLKDNLSREAKEKYKIYIFKDDTDKLEKEHQE YLKENNLNK*" gene 2065042..2065377 /gene="yozM" /locus_tag="BSU_18960" /old_locus_tag="BSU18960" promotor_no_box complement(2065416..2065516) /Source="Nicolas_upshift_promotors" /id="U1535" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.68031968031968" /psig="0.040959040959041" /xcortree=286 /SigmaFactorBS="aaagcgttggtgactgcattagagtctaaaaactacatatcc tcttttaaagaagatagagagagattacgtgtgaatactaaaaaaaaataaagaataa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts complement(2065423) /Source="Nicolas_upshifts" /id="D1038" /incds=0 /nref=148 /ntot=238 /MaxReadThrough="2.4012" /MaxDrop="4.9328" /score="17.2005818" /energy="-10" /TU="NA" /idTUdmin="U1535" /TUdmin="-11" /isTUend="TRUE" CDS complement(2065424..2069029) /gene="yobI" /locus_tag="BSU_18970" /old_locus_tag="BSU18970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15128444; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phage repair NTPase with transmembrane helices; putative defective prophage 6" /protein_id="NP_389778.1" /db_xref="EnsemblGenomes-Gn:BSU18970" /db_xref="EnsemblGenomes-Tr:CAB13789" /db_xref="GOA:O34784" /db_xref="InterPro:IPR011646" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13501" /db_xref="UniProtKB/Swiss-Prot:O34784" /translation="MGEIKKKFVQWLEKLLIRLKEPNVKEESLFEDLSPSNDVDTDGK YSKALSWGLENKKVKNIALTGPYGSGKSSILNTFQKQYSREYSFLNISLATFNTDTDD MENKLEKSILQQMIYRVHDRTIPFSRFKRIKHIRTKSIIINLIFFFAFIIVGIYLFKP DALKGIYAETLVSRSLGTEDQQQIRLTILLALFFIVYPLLAYKRIYHFVRANLKLNKV TIANTTLEKNTGEENSSIFDKYLDEILYFFEASKYNVVIFEDLDRFNNIGIFERLREL NELINNSEQIDRRVVFIYAIKDDIFGDADTEKLTRDRTKFFDFIIPVIPIINASNSGD ILKKKIKHSPYSDLINTHFLEDVTIYIDDMRVLKNIFNEFVIYQQKLSAIDLDPNKML AMIIYKNIYPVDFSKLQYNKGLVYEIFQKKQLIIEEQIKLINAKIQQLERKLANIEVE SLKSIAELNFIYLSELEISNLNSNYDINIDGEVFRGNTSNKDRFFEKLKNADTIYCYL RNRNGPATIKEIATVFGRKPNYFEREDAIKAIEKNEIQKFKKELLELEREKQEIRAQS LQVLITKMNSKDVFSDKLYEKKLLVYLLRHGYIDEMYNHYITYFYPESLSLSDIKFVF SIKNHESLPYSFELDNIGKIMSKLVGAEFKQIEVLNFHLLNYIMDHSEYRNYYDSIIE RLANGSKESVTFIDGFKERAINKAAFIQSISSKWDDFWSFIELRSNYTQQKKEEYLSD ILTYADIADIIRMNKESVMSFTLSKYLNLLSLVSDEEKIKELLLKLQVKFKSLDHLLN SETIYDFVVQRNLYEINIKTLSVILNDAPNITYAAVKNSDQQAVINYVNDNIDIFVEK VLLTEEIEEPEESFLELLNREDLDKRVKHAMIMKKTFAISDIGELIKELWPIVIRENK MVACWSNVITSYVEYNKKMPDFLIAFLNNPVNRKELSKNNIEAFDDKFDEAILEDISE EIINSRDITDETFEVLIASIQSWIYFPLGNVSEKRAKLLIDNDLLSLTPENFKELKLN FDTLHIQLALRNPDEFIDKQGDFSLDANDIKQLIDSNELSQFNKEIFVQHLNSNCLTD GNNDILKDTIYFINEHNLKITNELLTFLLESPTTLDTRLSLLAGQIKHIDNESITEFL TKIGEPYSEIAEKGRRIKISNNRTNKALVTALESKNYISSFKEDRERLRVNTKKK*" gene complement(2065424..2069029) /gene="yobI" /locus_tag="BSU_18970" /old_locus_tag="BSU18970" upshifts complement(2065456) /Source="Nicolas_upshifts" /id="U1535" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.68031968031968" /psig="0.040959040959041" /xcortree=286 /SigmaFactorBS="aaagcgttggtgactgcattagagtctaaaaactacatatcc tcttttaaagaagatagagagagattacgtgtgaatactaaaaaaaaataaagaataa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2069030..2069174) /Source="Nicolas_S_feature" /locus_tag="new_2069030_2069174_c" /HighExp="LBGstat, Lbstat, M0t90, T3.0H, T1.30H, T3.30H, MG 150, T2.30H, T4.0H, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.936" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S713" misc_feature complement(2069167..2069186) /Source="Nicolas_upshift_promotors" /id="U1536" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=3220 /SigmaFactorBS="tgtgttgtttattgatcatctttttttcagaaacttttaatg ccctttCATGTTACAATTAATAGTGAatttcaactggcgataaaggactatattagat g" /listShort="S713, yobI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2069174) /Source="Nicolas_upshifts" /id="U1536" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=3220 /SigmaFactorBS="tgtgttgtttattgatcatctttttttcagaaacttttaatg ccctttCATGTTACAATTAATAGTGAatttcaactggcgataaaggactatattagat g" /listShort="S713, yobI" /GFF_Attribute="listLong" S_feature complement(2069176..2069261) /Source="Nicolas_S_feature" /locus_tag="new_2069176_2069261_c" /HighExp="LBGstat, C30, Lbstat, M0t90, GM 120, GM 25, GM 150, nit, GM 90, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigWXY" /TUshortPSig="0.936, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S714" CDS complement(2069262..2069561) /gene="yoyA" /locus_tag="BSU_18979" /old_locus_tag="BSU18979" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type h : extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative fragment of phage protein; putative defective prophage 6" /db_xref="PSEUDO:CAX52636.1" /translation="MATEGYGGNNSAPSRSIGFSEFCETLEKNEVVKPENKKSSLDLN NSLDYWKSRFNPGGNLSALDSQVLDIIKKAYNLGMVNKDNMLLRNEAINAYKNSI*" gene complement(2069262..2069561) /gene="yoyA" /locus_tag="BSU_18979" /old_locus_tag="BSU18979" /pseudo S_feature complement(2069562..2069699) /Source="Nicolas_S_feature" /locus_tag="new_2069562_2069699_c" /HighExp="LBGstat, C30, MG 150, GM 150, M0t90, Lbstat, GM 25, GM 90, GM 120, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigWXY" /TUshortPSig="0.936, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S715" promotor_-10 complement(2069677..2069695) /Source="Nicolas_upshift_promotors" /id="U1537" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.936063936063936" /psig="0.936063936063936" /xcortree=3232 /SigmaFactorBS="gtgaaaggaacttgcaaaatgcaggttcttttttgtattcaa ttATTAAATcatttgaatgattGTCGATATTTAATATGTGTaaaaatggaaaaggtgc t" /listShort="S715, yoyA, S714, S713, yobI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2069699) /Source="Nicolas_upshifts" /id="U1537" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.936063936063936" /psig="0.936063936063936" /xcortree=3232 /SigmaFactorBS="gtgaaaggaacttgcaaaatgcaggttcttttttgtattcaa ttATTAAATcatttgaatgattGTCGATATTTAATATGTGTaaaaatggaaaaggtgc t" /listShort="S715, yoyA, S714, S713, yobI" /GFF_Attribute="listLong" promotor_-35 complement(2069709..2069715) /Source="Nicolas_upshift_promotors" /id="U1537" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.936063936063936" /psig="0.936063936063936" /xcortree=3232 /SigmaFactorBS="gtgaaaggaacttgcaaaatgcaggttcttttttgtattcaa ttATTAAATcatttgaatgattGTCGATATTTAATATGTGTaaaaatggaaaaggtgc t" /listShort="S715, yoyA, S714, S713, yobI" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(2069732..2070115) /gene="asrE" /locus_tag="BSU_misc_RNA_74" /product="small regulatory antitoxin RNA, toxin-antitoxin type I system (BsrE/AsrE)" /experiment="publication(s) with functional evidences, PMID:18948176, 23059907, 24576839, 26565032, 26940229" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 23059907, 24576839, 26565032, 26940229; Product type n: RNA" gene complement(2069732..2070115) /gene="asrE" /locus_tag="BSU_misc_RNA_74" S_feature complement(2069746..2069982) /Source="Nicolas_S_feature" /locus_tag="new_2069746_2069982_c" /HighExp="Salt, Etha, S4, LoTm, dia5, Diami, S5, MG 120, S3, aero" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.518, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S716" promotor_-35 2069779..2069781 /Source="Nicolas_upshift_promotors" /id="U1538" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.774225774225774" /psig=1 /xcortree=474 /SigmaFactorBS="tttgcaagttcctttcacgttgtcaatatattgtgaaTTTtt aacgacaagggcaTTTATGTATAGTATGATATTtcctgtacagtaagttttgctcact c" /listShort="S717" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2069789) /Source="Nicolas_upshifts" /id="D1039" /incds=0 /nref=39 /ntot=216 /MaxReadThrough="3.37292" /MaxDrop="5.0558" /score="17.2005818" /energy="-10" /TU="U1541" /idTUdmin="U1539" /TUdmin=1 /isTUend="TRUE" promotor_-10 2069797..2069816 /Source="Nicolas_upshift_promotors" /id="U1538" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.774225774225774" /psig=1 /xcortree=474 /SigmaFactorBS="tttgcaagttcctttcacgttgtcaatatattgtgaaTTTtt aacgacaagggcaTTTATGTATAGTATGATATTtcctgtacagtaagttttgctcact c" /listShort="S717" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2069802 /Source="Nicolas_upshifts" /id="U1538" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.774225774225774" /psig=1 /xcortree=474 /SigmaFactorBS="tttgcaagttcctttcacgttgtcaatatattgtgaaTTTtt aacgacaagggcaTTTATGTATAGTATGATATTtcctgtacagtaagttttgctcact c" /listShort="S717" /GFF_Attribute="listLong" S_feature 2069824..2069977 /Source="Nicolas_S_feature" /locus_tag="new_2069824_2069977" /HighExp="T1.30H, B60, T2.0H, M9-stat, BT, T0.30H, B36, T1.0H, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.87861900000000004" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S717" CDS 2069883..2069975 /gene="bsrE" /locus_tag="BSU_18978" /old_locus_tag="BSU18978" /experiment="publication(s) with functional evidences, PMID:26565032, 26940229" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26565032, 26940229; Product type f: factor" /codon_start=1 /transl_table=11 /product="type I toxin (BsrE/AsrE)" /protein_id="YP_009513965.1" /translation="MSTFQALMLMLAIGSFIIALLTYIEKIDLP*" gene 2069883..2069975 /gene="bsrE" /locus_tag="BSU_18978" /old_locus_tag="BSU18978" downshifts 2069934 /Source="Nicolas_upshifts" /id="D1040" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="6.71009" /MaxDrop="3.13767" /score="33.1812693" /energy="-14.4" /TU="U1538" /idTUdmin="U1538" /TUdmin="-66" /isTUend="FALSE" S_feature complement(2069984..2070118) /Source="Nicolas_S_feature" /locus_tag="new_2069984_2070118_c" /HighExp="T-0.40H, T0.0H, T0.30H, Salt, S4, M9-stat, T-1.10H, S7, B60, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.518, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S718" downshifts 2070000 /Source="Nicolas_upshifts" /id="D1041" /incds=0 /nref=135 /ntot=196 /MaxReadThrough="2.41468" /MaxDrop="5.72925" /score="33.1812693" /energy="-14.4" /TU="NA" /idTUdmin="U1538" /TUdmin=0 /isTUend="TRUE" downshifts complement(2070027) /Source="Nicolas_upshifts" /id="D1042" /incds=0 /nref=13 /ntot=114 /MaxReadThrough="6.34283" /MaxDrop="4.1536" /score="3.24083135" /energy="-14.3" /TU="U1539,U1541" /idTUdmin="U1539" /TUdmin="-237" /isTUend="FALSE" upshifts complement(2070118) /Source="Nicolas_upshifts" /id="U1539" /multdbtbs="-" /comp="M3" /sig="SigA" /pcomp="0.44955044955045" /psig="0.518481518481518" /xcortree=755 /SigmaFactorBS="cttgaggtttattgtaatgcatttcacggaaaatgtgttata atcagtttTAcaatacattacagtgcatttctttaatgagaaatgcataaaataaaaa a" /listShort="S718, S716" /GFF_Attribute="listLong" S_feature complement(2070120..2070243) /Source="Nicolas_S_feature" /locus_tag="new_2070120_2070243_c" /HighExp="T-0.40H, T0.0H, T0.30H, Salt, T-1.10H, T1.0H, T-1.40H, Etha, SMMPr, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S719" misc_feature complement(2070127..2070128) /Source="Nicolas_upshift_promotors" /id="U1539" /multdbtbs="-" /comp="M3" /sig="SigA" /pcomp="0.44955044955045" /psig="0.518481518481518" /xcortree=755 /SigmaFactorBS="cttgaggtttattgtaatgcatttcacggaaaatgtgttata atcagtttTAcaatacattacagtgcatttctttaatgagaaatgcataaaataaaaa a" /listShort="S718, S716" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2070244..2071086) /gene="yobJ" /locus_tag="BSU_18980" /old_locus_tag="BSU18980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11866510" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function; putative defective prophage 6" /protein_id="NP_389779.1" /db_xref="EnsemblGenomes-Gn:BSU18980" /db_xref="EnsemblGenomes-Tr:CAB13790" /db_xref="GOA:O34774" /db_xref="SubtiList:BG13502" /db_xref="UniProtKB/Swiss-Prot:O34774" /translation="MELLDIWNWIQQNGILTAVITGIVALLFNQRQKSIERFYSQSGE TLEKILEPMYYSLKEIKNEEDENHKMVLIEKFFEEYSGKKGKLSKLRNILLIDQILNT EDCFREYILNKNSENRKKLFYKMRMLDQAVNKEYRSIFVTLNKNYNWYKVLFRTNYIL SAVFVFVRWFKETLAFFVGASAFAFIPLLYDKYLGEQVLGNWLEVNKLIFGLSCSALY IFWIIHYFLLKDTMQRKDEISLFQEWFDKTKLGKWTNKNVWGKIGNWNVERRARRVRN DEDV*" gene complement(2070244..2071086) /gene="yobJ" /locus_tag="BSU_18980" /old_locus_tag="BSU18980" promotor_-35 2070581..2070584 /Source="Nicolas_upshift_promotors" /id="U1540" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.011988011988012" /xcortree=47 /SigmaFactorBS="aagcaaatgctgaagcaccgacaaaaaaagctagagtttctt taaacCATCtaacaaaaacaaaaaCAGCGcttaaaatataattcgttctaaaaagaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2070594 /Source="Nicolas_upshifts" /id="U1540" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.011988011988012" /xcortree=47 /SigmaFactorBS="aagcaaatgctgaagcaccgacaaaaaaagctagagtttctt taaacCATCtaacaaaaacaaaaaCAGCGcttaaaatataattcgttctaaaaagaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2070600..2070604 /Source="Nicolas_upshift_promotors" /id="U1540" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.011988011988012" /xcortree=47 /SigmaFactorBS="aagcaaatgctgaagcaccgacaaaaaaagctagagtttctt taaacCATCtaacaaaaacaaaaaCAGCGcttaaaatataattcgttctaaaaagaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2071112..2071127) /Source="Nicolas_upshift_promotors" /id="U1541" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1677 /SigmaFactorBS="agaagttttctagtcccgttttataTGAAACCTTTtttattt tagcCCGTATTAAAAGTAAAttcagagagaaggggagaagcttaattggagttattag a" /listShort="yobJ, S719, S718, S716, S715, yoyA, S714" /listLong="S713, yobI" /label="promotor_-10" upshifts complement(2071113) /Source="Nicolas_upshifts" /id="U1541" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1677 /SigmaFactorBS="agaagttttctagtcccgttttataTGAAACCTTTtttattt tagcCCGTATTAAAAGTAAAttcagagagaaggggagaagcttaattggagttattag a" /listShort="yobJ, S719, S718, S716, S715, yoyA, S714" /listLong="S713, yobI" S_feature complement(2071115..2071197) /Source="Nicolas_S_feature" /locus_tag="new_2071115_2071197_c" /HighExp="MG 150, T-3.40H, Cold, SMM, Lbstat, SMMPr, ferm, T-2.40H, Fru, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S720" promotor_-35 complement(2071139..2071148) /Source="Nicolas_upshift_promotors" /id="U1541" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1677 /SigmaFactorBS="agaagttttctagtcccgttttataTGAAACCTTTtttattt tagcCCGTATTAAAAGTAAAttcagagagaaggggagaagcttaattggagttattag a" /listShort="yobJ, S719, S718, S716, S715, yoyA, S714" /listLong="S713, yobI" /label="promotor_-35" S_feature complement(2071199..2071285) /Source="Nicolas_S_feature" /locus_tag="new_2071199_2071285_c" /HighExp="Lbstat, M0t90, HiOs, HiTm, M40t90, dia15, S2, S1, T-0.40H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S721" downshifts complement(2071242) /Source="Nicolas_upshifts" /id="D1043" /incds=0 /nref=5 /ntot=191 /MaxReadThrough="4.07519" /MaxDrop="4.09712" /score="-3.79237769" /energy="-8.4" /TU="U1542" /idTUdmin="U1542" /TUdmin="-110" /isTUend="FALSE" CDS complement(2071286..2071744) /gene="rttM" /locus_tag="BSU_18990" /old_locus_tag="BSU18990" /function="17.2: Prophage functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin inhibiting Rnase RttL" /protein_id="NP_389780.1" /db_xref="EnsemblGenomes-Gn:BSU18990" /db_xref="EnsemblGenomes-Tr:CAB13791" /db_xref="InterPro:IPR018958" /db_xref="PDB:2PRV" /db_xref="SubtiList:BG13503" /db_xref="UniProtKB/Swiss-Prot:O34596" /translation="MIYSKVENFINENKQNAIFTEGASHENIGRIEENLQCDLPNSYK WFLEKYGAGGLFGVLVLGYNFDHASVVNRTNEYKEHYGLTDGLVVIEDVDYFAYCLDT NKMKDGECPVVEWDRVIGYQDTVADSFIEFFYNKIQEAKDDWDEDEDWDD*" gene complement(2071286..2071744) /gene="rttM" /locus_tag="BSU_18990" /old_locus_tag="BSU18990" CDS complement(2071754..2073556) /gene="rttL" /locus_tag="BSU_19000" /old_locus_tag="BSU19000" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phage toxin ribonuclease; putative defective prophage 6" /protein_id="NP_389781.1" /db_xref="EnsemblGenomes-Gn:BSU19000" /db_xref="EnsemblGenomes-Tr:CAB13792" /db_xref="GOA:O34330" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR026834" /db_xref="SubtiList:BG13504" /db_xref="UniProtKB/Swiss-Prot:O34330" /translation="MKVFEADSLLFEADKRTKEYKELRSQMVKLKKAFKEVANLDDSE FSGKGADNIKAFYHGHVGVTDQWIDLIDMKIAFLSSMSATLEDAKMSDAYIEESFLEH ELANAYAKSKSIMSEQKKAMKDILNNINDILPLEIFSTEDFKDKLSSADDKREKTIDK LNKLDEDLKTEYAETEPNEQFIQQDFKKLQESTGKGKNATPIHYNAKAYRESDIHKKK GDIEKHSEAYLSVKKEEAKEREIKELKKKLNDGVSDPDEYLEIAKKVGYENLEPTQVQ LAVQIEQAKQLEGAGEITWDIVKGVGVGLYDVGKDTVTGIWDFITDPGETLSALGNAA MHPVKTYDAISAAIEESYQKDMVNGDAYSRSRWVTYAIGSVAVAVVGTKGAGAINKAD AAGKVINKASQAGKKIKDVKIPDLLPYNPKYKLALADNVPYNVVDSQNLKNELLTNAK KIPDGTRKPFTGQKKSPPWLNKEKYDAYEIEGKVKAKGKVKDVSRRVYTMKDIDINQK TEFGVTNLQLMKNGNAPYAKDGTQINLHHLIQEEPGPMLEIPNSLHTKYSDVIHQLKS DGESFRNDKVLKAQYESFRKRYWKWRAKQFENEN*" gene complement(2071754..2073556) /gene="rttL" /locus_tag="BSU_19000" /old_locus_tag="BSU19000" promotor_-10 complement(2073580..2073599) /Source="Nicolas_upshift_promotors" /id="U1542" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=3217 /SigmaFactorBS="gtgtgatgtataagacagtcattttggctgtctttttcTGTT ATTCaattagattacTGTGGTAAAATTTACATAGAagtagtctaggaaggagaatgat a" /listShort="yobL, yobK, S721, S720" /listLong="yobJ, S719, S718, S716" /label="promotor_-10" upshifts complement(2073596) /Source="Nicolas_upshifts" /id="U1542" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=3217 /SigmaFactorBS="gtgtgatgtataagacagtcattttggctgtctttttcTGTT ATTCaattagattacTGTGGTAAAATTTACATAGAagtagtctaggaaggagaatgat a" /listShort="yobL, yobK, S721, S720" /listLong="yobJ, S719, S718, S716" promotor_-35 complement(2073611..2073618) /Source="Nicolas_upshift_promotors" /id="U1542" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=3217 /SigmaFactorBS="gtgtgatgtataagacagtcattttggctgtctttttcTGTT ATTCaattagattacTGTGGTAAAATTTACATAGAagtagtctaggaaggagaatgat a" /listShort="yobL, yobK, S721, S720" /listLong="yobJ, S719, S718, S716" /label="promotor_-35" CDS complement(2073658..2074215) /gene="yobM" /locus_tag="BSU_19010" /old_locus_tag="BSU19010" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; putative defective prophage 6" /protein_id="NP_389782.3" /db_xref="EnsemblGenomes-Gn:BSU19010" /db_xref="EnsemblGenomes-Tr:CAB13793" /db_xref="InterPro:IPR018958" /db_xref="SubtiList:BG13505" /db_xref="UniProtKB/Swiss-Prot:O34377" /translation="MTNFVHKTVNGLKSLLDEKGAIKLFCSEGDIMEFLVTFSQDKAT LNDIQSFEAKHQLTLPQDYQKFMTLHNGAKIFEILSDGENIGGGLQLFSLEEIEEELK YEDLFEDINGIPIGYLLEECHLMIDKDKVNQGDPNYLYIFESGLEYNPLNLNFEKFLD RYILANGEPFWDWRYYTAENYYRTR*" gene complement(2073658..2074215) /gene="yobM" /locus_tag="BSU_19010" /old_locus_tag="BSU19010" S_feature complement(2074222..2074617) /Source="Nicolas_S_feature" /locus_tag="new_2074222_2074617_c" /HighExp="M0t90, LoTm, M40t90, Lbstat, LBGstat, M9-stat, T0.30H, T2.30H, T1.0H, T2.0H" /AntisenseName="yobN" /AntisenseCor="-6.3634699133798794E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S722" promotor_-35 2074280..2074285 /Source="Nicolas_upshift_promotors" /id="U1543" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1014 /SigmaFactorBS="ctttcaaattccaaaagatgtgaacagatcGTGATAggtgct cttttcagtGAATATAATGCAATAAATTctaaaaagaggtgcctccaaaaattgaatt c" /listShort="S723, yobN, S724" /listLong="S725, yobO, S727, S728" /label="promotor_-35" promotor_-10 2074301..2074319 /Source="Nicolas_upshift_promotors" /id="U1543" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1014 /SigmaFactorBS="ctttcaaattccaaaagatgtgaacagatcGTGATAggtgct cttttcagtGAATATAATGCAATAAATTctaaaaagaggtgcctccaaaaattgaatt c" /listShort="S723, yobN, S724" /listLong="S725, yobO, S727, S728" /label="promotor_-10" upshifts 2074310 /Source="Nicolas_upshifts" /id="U1543" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1014 /SigmaFactorBS="ctttcaaattccaaaagatgtgaacagatcGTGATAggtgct cttttcagtGAATATAATGCAATAAATTctaaaaagaggtgcctccaaaaattgaatt c" /listShort="S723, yobN, S724" /listLong="S725, yobO, S727, S728" S_feature 2074312..2074438 /Source="Nicolas_S_feature" /locus_tag="new_2074312_2074438" /HighExp="S3, S4, S5, S6, M9-stat, S8, S7, T5.0H, T4.0H, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S723" CDS 2074343..2075779 /gene="yobN" /locus_tag="BSU_19020" /old_locus_tag="BSU19020" /EC_number="1.4.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amine oxidase (flavoprotein)" /protein_id="NP_389783.2" /db_xref="EnsemblGenomes-Gn:BSU19020" /db_xref="EnsemblGenomes-Tr:CAB13794" /db_xref="GOA:O34363" /db_xref="InterPro:IPR001613" /db_xref="InterPro:IPR002937" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13506" /db_xref="UniProtKB/Swiss-Prot:O34363" /translation="MNSLMNDDMVKIIRNGLSASQHPKHILVIGAGLSGLVSASLLKN AGHRVTILEASGRAGGRVCTLRSPFSDDLYFNAGPMRIPNNHSLTLEYIKKFKLPTNV FINRTPMDIIYANGIKTRLQVFERAPGILRYPVAPNEQGKTSEELMLSLLQPILNFIN QNPARNWRIVEEQYKNHSLSSFLNTYFSYGAIDMIGVLLDMEAYMGMSLVEVLRESIF FSSPAHFYEITGGMDLLPHAFLPQLKTNILYHQKMMKMSQGENRVTIHCQHQQTAEFT SFTADLAIVTIPFSTLRFVKVEPYHSFSYYKRRAIRELNYISATKIGIEFKSRFWEKA GQHGGKSITDLPIRFSYYPSRNIGANGHAVILASYTWADEALIWDSLSEGERIQYTLL NLSEIYGDIVWSEFVSGTSFSWSQYPYSAGGFTAFEPGQELELYPYIPVPEGRVHFAG EHASLTHAWMQGAIESGIRVAYEVNRLP*" gene 2074343..2075779 /gene="yobN" /locus_tag="BSU_19020" /old_locus_tag="BSU19020" promotor_-10 complement(2074603..2074622) /Source="Nicolas_upshift_promotors" /id="U1544" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig="0.997002997002997" /xcortree=3167 /SigmaFactorBS="atgatgtccatcggggttctgttgataaatacattTGTTGGC aatttgaatttttTGATATATTCTAAGGTTAACgaatggttattcggtatgcgcatcg g" /listShort="S722, yobM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2074617) /Source="Nicolas_upshifts" /id="U1544" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig="0.997002997002997" /xcortree=3167 /SigmaFactorBS="atgatgtccatcggggttctgttgataaatacattTGTTGGC aatttgaatttttTGATATATTCTAAGGTTAACgaatggttattcggtatgcgcatcg g" /listShort="S722, yobM" /GFF_Attribute="listLong" promotor_-35 complement(2074636..2074642) /Source="Nicolas_upshift_promotors" /id="U1544" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig="0.997002997002997" /xcortree=3167 /SigmaFactorBS="atgatgtccatcggggttctgttgataaatacattTGTTGGC aatttgaatttttTGATATATTCTAAGGTTAACgaatggttattcggtatgcgcatcg g" /listShort="S722, yobM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2075780..2076111 /Source="Nicolas_S_feature" /locus_tag="new_2075780_2076111" /HighExp="S3, S8, S4, S5, S7, M9-stat, S6, T5.0H, C30, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S724" promotor_-35 2076093..2076101 /Source="Nicolas_upshift_promotors" /id="U1545" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=526 /SigmaFactorBS="tttcattgacttacatttcttgaaaaccagtataaatcctAA AGGAATTttgtaacaaaTACAGAATTGGAAAGAGAAgcgccaaaagaaatgctaactc c" /listShort="S725, yobO, S727, S728" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2076112..2076130 /Source="Nicolas_upshift_promotors" /id="U1545" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=526 /SigmaFactorBS="tttcattgacttacatttcttgaaaaccagtataaatcctAA AGGAATTttgtaacaaaTACAGAATTGGAAAGAGAAgcgccaaaagaaatgctaactc c" /listShort="S725, yobO, S727, S728" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2076113..2076205 /Source="Nicolas_S_feature" /locus_tag="new_2076113_2076205" /HighExp="M9-stat, T1.30H, T2.0H, S2, T2.30H, Lbstat, BC, T0.30H, T3.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.995" /label="S725" upshifts 2076113 /Source="Nicolas_upshifts" /id="U1545" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=526 /SigmaFactorBS="tttcattgacttacatttcttgaaaaccagtataaatcctAA AGGAATTttgtaacaaaTACAGAATTGGAAAGAGAAgcgccaaaagaaatgctaactc c" /listShort="S725, yobO, S727, S728" /GFF_Attribute="listLong" CDS 2076206..2078626 /gene="yobO" /locus_tag="BSU_19030" /old_locus_tag="BSU19030" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11562162, 19450535; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage-related pre-neck appendage protein; defective prophage 6" /protein_id="NP_389784.1" /db_xref="EnsemblGenomes-Gn:BSU19030" /db_xref="EnsemblGenomes-Tr:CAB13795" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="InterPro:IPR021865" /db_xref="InterPro:IPR024535" /db_xref="SubtiList:BG13507" /db_xref="UniProtKB/Swiss-Prot:O34433" /translation="MVHFKNCPDPSLNANSQSHPEFSSELEHIKTRMQNFIKHSVTDQ NIEVTDARVTAEGEVTSLLKERLDKEYYRLLSKITREVNVADFGAVPDGRDNTEAFRK AIGNGRVKVHVPAGEYLVQGIKLPSWTTIVGQGKGITVIKLHEDTPAHEWVITNDDYQ NGNRNIFVQGMSLDWNPSRQCGVRNPGGQFSSCLTFAKVEYGWIKDVEAINAGLHGID ITSPTYDHLPDTDWTKDGSRYIWIDNCVTYGSGDDGITTHYSEYIFISNCHSGNPRGT EFAEGVSNSNGIEIDDGSRHVWLLNNFTSGNIRGVEVKAHELWPASQNVHIIGHISYR DVRAFDLRHIGHHQITDPESTTAYDVTLIDCSAVEPVFNSLYDAVTPRALVISAYKNV NVSGFTAIGDPDYDYKENPVVALQYRSQNITINGIKIRGFKKAGVDINLSGGSNKTDY IKISNFDIYKSAPKGISIGGGLYNVNILNGTMITDNGTVAIQSPNNQATILGVQSEGY SVAASIKGQTYQQVPINLKGGIQLATTSGFAVNQTSAVIAGTGDITARGERNAVISSS GGSSTEGSRALIASSNNAHIRGNQASRTILSSENIILEEPYTVAGGHQSIKWLLDSVR GNGTFAGAISSSLGGYGEYFESSTGQLIHTGTIVTLRGEKIVPANVGDYMLGVISETS AFISGASSFVWQGRYLTNEFGGFIYETVTDEESGELIRVPKQNPDYDTALEANYHSRA ARDEWHVVGLVGQHYVRIDETVNQGDYLTAHNGIGTKATEGSWKVMKITSAYTSEKGY GIALTVIK*" gene 2076206..2078626 /gene="yobO" /locus_tag="BSU_19030" /old_locus_tag="BSU19030" S_feature complement(2078548..2079183) /Source="Nicolas_S_feature" /locus_tag="new_2078548_2079183_c" /HighExp="MG 150, S8, MG 120, S7, MG 90, GM-0.1, Glu, Fru, GM-0.2, GM 5" /AntisenseName="yobO" /AntisenseCor="0.134597835896198" /AntisenseRegPval="-1.6" /CDS_PredictionProba="0.40121099999999998" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S726" S_feature 2078627..2079084 /Source="Nicolas_S_feature" /locus_tag="new_2078627_2079084" /HighExp="M9-stat, Lbstat, BC, T1.30H, S2, T0.30H, T2.0H, T3.0H, T2.30H, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.995" /label="S727" promotor_-35 2079059..2079066 /Source="Nicolas_upshift_promotors" /id="U1546" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.488511488511489" /psig="0.896103896103896" /xcortree=87 /SigmaFactorBS="tctaaattcatttcaccgttactaaaagtaatcCTTGCATTc cttcgccctcCATGCTATATTCATATAGCGatgagctgaattgtgtaagccgatgtac a" /listShort="S728" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2079078..2079097 /Source="Nicolas_upshift_promotors" /id="U1546" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.488511488511489" /psig="0.896103896103896" /xcortree=87 /SigmaFactorBS="tctaaattcatttcaccgttactaaaagtaatcCTTGCATTc cttcgccctcCATGCTATATTCATATAGCGatgagctgaattgtgtaagccgatgtac a" /listShort="S728" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2079086..2079196 /Source="Nicolas_S_feature" /locus_tag="new_2079086_2079196" /HighExp="LoTm, S7, HPh, LPhT, S8, BT, S6, G/S, S0, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.896, 1" /TUlongSig="SigEF" /TUlongPSig="0.995" /label="S728" upshifts 2079086 /Source="Nicolas_upshifts" /id="U1546" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.488511488511489" /psig="0.896103896103896" /xcortree=87 /SigmaFactorBS="tctaaattcatttcaccgttactaaaagtaatcCTTGCATTc cttcgccctcCATGCTATATTCATATAGCGatgagctgaattgtgtaagccgatgtac a" /listShort="S728" /GFF_Attribute="listLong" misc_RNA 2079096..2079203 /gene="bsrF" /locus_tag="BSU_misc_RNA_75" /product="small untranslated regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 19542274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 19542274; Product type n: RNA" gene 2079096..2079203 /gene="bsrF" /locus_tag="BSU_misc_RNA_75" downshifts 2079181 /Source="Nicolas_upshifts" /id="D1044" /incds=0 /nref=65 /ntot=254 /MaxReadThrough="1.60135" /MaxDrop="9.06442" /score="30.7999406" /energy="-13.9" /TU="NA" /idTUdmin="U1545" /TUdmin=7 /isTUend="TRUE" CDS complement(2079214..2079546) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" /function="16.1: Circulate" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10658654, 10816431, 13129613, 15856219, 17372352, 28724440; Product type f : factor" /codon_start=1 /transl_table=11 /product="molecular chaperone for secreting proteins" /protein_id="NP_389785.1" /db_xref="EnsemblGenomes-Gn:BSU19040" /db_xref="EnsemblGenomes-Tr:CAB13796" /db_xref="GOA:P37584" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR008231" /db_xref="InterPro:IPR012340" /db_xref="PDB:2NZH" /db_xref="PDB:2NZO" /db_xref="SubtiList:BG10809" /db_xref="UniProtKB/Swiss-Prot:P37584" /translation="MAVIDDFEKLDIRTGTIVKAEEFPEARVPAIKLVIDFGTEIGIK QSSAQITKRYKPEGLINKQVIAVVNFPPRRIAGFKSEVLVLGGIPGQGDVVLLQPDQP VPNGTKIG*" gene complement(2079214..2079546) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" downshifts complement(2079228) /Source="Nicolas_upshifts" /id="D1045" /incds=0 /nref=28 /ntot=228 /MaxReadThrough="4.42209" /MaxDrop="5.706" /score="-8.98970984" /energy="-13.9" /TU="U1547" /idTUdmin="U1550" /TUdmin=0 /isTUend="TRUE" CDS complement(2079611..2080336) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478, 27038276; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_389786.1" /db_xref="EnsemblGenomes-Gn:BSU19050" /db_xref="EnsemblGenomes-Tr:CAB13797" /db_xref="GOA:O34901" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG13508" /db_xref="UniProtKB/Swiss-Prot:O34901" /translation="MLMDSLQEIICEKRTYTRLYHSHKHAYSQFLFPLEGSIDLETEG RQVKLNPDHFLYIPPQCEHRFRSIGRNECLVLDVPLHAMKIDEYRAGSGIEAALDPFW SSIRYLLTEEAKAGTANSLHMLVQYIKEKLQSHSYASIAYIHSHLFERLTIKKLAEIE HYHPAYYSSWFKKQTGKSPQNYIADLRLEEAKRMLMERNETLTVVSEALGFQNLSSFT RWFTKSTGMPPRLYRNTLYSDKK*" gene complement(2079611..2080336) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" CDS complement(2080351..2081094) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389787.1" /db_xref="EnsemblGenomes-Gn:BSU19060" /db_xref="EnsemblGenomes-Tr:CAB13798" /db_xref="GOA:O34376" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13509" /db_xref="UniProtKB/Swiss-Prot:O34376" /translation="MDDIRKIERLAAASWPAYFQKSIGKWLLRANFGVTKRANSVWTS ADMPEGDFQLEAELFYQSLGLPVCFHISNASPKGLDDALADSRYEKVDECFQMTALCR SIMSRTNDNSRFTYKWEQEPSSVWIDEFIQLEGFSPERHKGYKHIFERMPPCKTFFKM YDKESLTALGTVSVIDGYGGLSNIVVAEEHRGKGAGTQVIRVLTEWAKNNGAERMFLQ VMKENLAAVSLYGKIGFSPISEHHYRIKR*" gene complement(2080351..2081094) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" promotor_-10 complement(2081122..2081141) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2081141) /Source="Nicolas_upshifts" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" promotor_-35 complement(2081155..2081161) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2081172..2081747) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389788.1" /db_xref="EnsemblGenomes-Gn:BSU19070" /db_xref="EnsemblGenomes-Tr:CAB13799" /db_xref="GOA:O34892" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025996" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG13510" /db_xref="UniProtKB/Swiss-Prot:O34892" /translation="MSPRIGLTQKMIVDAAAEIADQEGVNGVSLAALSKKMNVRPPSL YNHINGLQAIRAELAVRGLTKLFDQMADSVTERKGDSAMLSLAHAYVDFAIENPGYYE AALLKVHDKRTEIVSDQIVCLVTKLLIENGYASEKTAIHATRGLRSLLHGFTVLIAKE AFEREEDILESLSFSIRTFLSGLLINNKNIM*" gene complement(2081172..2081747) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" CDS complement(2081753..2082454) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_389789.1" /db_xref="EnsemblGenomes-Gn:BSU19080" /db_xref="EnsemblGenomes-Tr:CAB13800" /db_xref="GOA:O34910" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13511" /db_xref="UniProtKB/Swiss-Prot:O34910" /translation="MRITQYQTVWQLTFFPALFPVNCYLVEEENEVTLIDAALPGSYK GIIQAVNQLGKPLQHILLTHAHGDHVGSLDTLAQTFPHAKVMISERDSFLLQGDTSLR QDEPQTPIKGGIPKHIQTKPHQLLTGGETIGSLLAIPTPGHTPGSMSFLDTRNGTLIA GDAFQLRGGIAVSGQIKWAFPFPAFATWNKEEAIKSAQLLADKAPSCLAVGHGKFLRS PSERMRQAIQKAKKG*" gene complement(2081753..2082454) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" promotor_-10 complement(2082484..2082503) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2082484) /Source="Nicolas_upshifts" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" promotor_-10 complement(2082488..2082503) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2082518..2082525) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2082518..2082525) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2082528) /Source="Nicolas_upshifts" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" CDS complement(2082531..2083013) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative effector of transcriptional regulator" /protein_id="NP_389790.1" /db_xref="EnsemblGenomes-Gn:BSU19090" /db_xref="EnsemblGenomes-Tr:CAB13801" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG13512" /db_xref="UniProtKB/Swiss-Prot:O34637" /translation="MGFSHITHLDLKRFAGLSQRTSNALEMTEERRIPALWDQLWKQD MSALLSQAEKDKSIIALYSNYEQETNGFYTFSVGTFQEYDDILPGPYENIDLPASAYA VFTSRIGPIEEIVLETWKEIWTWDKRHLRTFTGDFEMYDQNAAVPQRAQVNIYVAIKK *" gene complement(2082531..2083013) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" misc_feature complement(2083052..2083069) /Source="Nicolas_upshift_promotors" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2083056) /Source="Nicolas_upshifts" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" CDS complement(2083067..2084008) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389791.1" /db_xref="EnsemblGenomes-Gn:BSU19100" /db_xref="EnsemblGenomes-Tr:CAB13802" /db_xref="GOA:O34920" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026881" /db_xref="InterPro:IPR028349" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13513" /db_xref="UniProtKB/Swiss-Prot:O34920" /translation="MKLERLLAMVVLLISKKQVQAAELAELFEVSVRTIYRDIETINR AGIPIVTSQGSGGGIGIMETYRLEREWLKEEELFAIASALQSVSSMYEPVSHSTAYQK IKHLIPEQSTQAFKHQTEKWFIDMTAWGHTEDQKTLREKISAAIDRLLTISFTYTSAS GETLLRETEPYTLVCKAGHWYLYAYCLVRNDFRFFKLNRMKDLAILHQTFIRKDIQLD TLPWDKSWYQKDRLTELVILVQPSARQRIGEWFGYDVLHCCEEDEICQAVISLPEDQW LIGFLLQFGKDIEVLQPLHIRDKVKETIHHMQKIYET*" gene complement(2083067..2084008) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" downshifts complement(2083100) /Source="Nicolas_upshifts" /id="D1046" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="0.95712" /MaxDrop="3.62763" /score="-3.71616684" /energy="-9" /TU="NA" /idTUdmin="U1548" /TUdmin="-770" /isTUend="FALSE" promotor_-10 complement(2084038..2084057) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2084046) /Source="Nicolas_upshifts" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" promotor_-35 complement(2084071..2084075) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2084079..2084088 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2084101..2084120 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2084109 /Source="Nicolas_upshifts" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" S_feature 2084124..2084188 /Source="Nicolas_S_feature" /locus_tag="new_2084124_2084188" /HighExp="BT, S7, B36, S8, S6, Pyr, G/S, B60, Glucon, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S729" promotor_-35 2084160..2084165 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2084181..2084199 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2084190 /Source="Nicolas_upshifts" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" CDS 2084214..2084759 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8990290, 11717295, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 11717295, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="mother cell-specific membrane sporulation protein" /protein_id="NP_389792.1" /db_xref="EnsemblGenomes-Gn:BSU19110" /db_xref="EnsemblGenomes-Tr:CAB13803" /db_xref="GOA:P94497" /db_xref="InterPro:IPR014743" /db_xref="SubtiList:BG12269" /db_xref="UniProtKB/Swiss-Prot:P94497" /translation="MHLTLQSVYPAIIIIFFLYKKIKRSIGYQPLKPRWLFTRIILFS LFAFGLSIFSAIHPFLYGYLILGILGGWLLVFFAKKNISFEKRRGKIYFRTHIWVEVI LLTLFLSRFLYRVTELYLTSPDLNRLGSYSQSIGTDPLTIGVCFLIAVYYIGFSSFII KLSRNELEQHEYNKEKDILAR*" gene 2084214..2084759 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" downshifts 2084718 /Source="Nicolas_upshifts" /id="D1047" /incds=0 /nref=20 /ntot=63 /MaxReadThrough="3.56215" /MaxDrop="4.5413" /score="-4.21976438" /energy="-17.7" /TU="U1552,U1553" /idTUdmin="U1552" /TUdmin="-132" /isTUend="FALSE" CDS complement(2084786..2085109) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15948947, 16406068, 16430705, 19170879, 19995076, 25213752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16406068, 16430705, 19170879, 19995076, 25213752; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (multiple metal-sensing ArsR-SmtB transcriptional repressor favouring Zn2+)" /protein_id="NP_389793.1" /db_xref="EnsemblGenomes-Gn:BSU19120" /db_xref="EnsemblGenomes-Tr:CAB13804" /db_xref="GOA:O31844" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13748" /db_xref="UniProtKB/Swiss-Prot:O31844" /translation="MTEFRETEQSAADLDEETLFLVAQTFKALSDPTRIRILHLLSQG EHAVNGIAEKLNLLQSTVSHQLRFLKNLRLVKSRREGTSIYYSPEDEHVLDVLQQMIH HTQHD*" gene complement(2084786..2085109) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" downshifts complement(2084793) /Source="Nicolas_upshifts" /id="D1048" /incds=0 /nref=73 /ntot=252 /MaxReadThrough="1.89304" /MaxDrop="4.873" /score="17.3750937" /energy="-18.6" /TU="NA" /idTUdmin="U1554" /TUdmin="-21" /isTUend="TRUE" promotor_-10 complement(2085130..2085149) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2085141) /Source="Nicolas_upshifts" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" promotor_-35 complement(2085162..2085169) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2085230..2085236 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2085247 /Source="Nicolas_upshifts" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" promotor_-10 2085251..2085270 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2085303..2085980 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative murein fragments glycosidase" /protein_id="NP_389794.1" /db_xref="EnsemblGenomes-Gn:BSU19130" /db_xref="EnsemblGenomes-Tr:CAB13805" /db_xref="GOA:O34636" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13514" /db_xref="UniProtKB/Swiss-Prot:O34636" /translation="MKKKRKGCFAAAGFMMIFVFVIASFLLVLLFFNRDLIKKLPIDT KTIVLERLTDYKPLVEEELESQGLSNYTSLILGMMYQESKGKGNDPMQSSESLGLKRN EITDPQLSVKQGIKQFTLMYKTGKEKGVDLDTIIQSYNMGAGYIDFVAEHGGTHTEEL AKQYSEQQVKKNPDLYTCGGNAKNFRYPYCYGDYTYAEKVKEKTKTVEESLQVATLET MESKAHE*" gene 2085303..2085980 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" downshifts 2085972 /Source="Nicolas_upshifts" /id="D1049" /incds=0 /nref=207 /ntot=268 /MaxReadThrough="3.9729" /MaxDrop="8.52704" /score="-4.21976438" /energy="-17.7" /TU="U1555" /idTUdmin="U1555" /TUdmin="-44" /isTUend="FALSE" CDS complement(2086070..2086606) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19222757, 24214949; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389795.1" /db_xref="EnsemblGenomes-Gn:BSU19140" /db_xref="EnsemblGenomes-Tr:CAB13806" /db_xref="GOA:O31845" /db_xref="InterPro:IPR007352" /db_xref="InterPro:IPR013833" /db_xref="SubtiList:BG13749" /db_xref="UniProtKB/Swiss-Prot:O31845" /translation="MNQTENKPKNYTGIVLTLTVLINGLIAVLFFMPKLDQFSHANIH ILPMLNAIFNSFTFIFLLAALIMIKQKNIKAHKRFILAAFTTTLLFLICYVTYHSIAE NTLYGGEGIMRPIYFFILITHICLSAIIVPLALFTLIRGFSMQVERHKKIARWTMPLW LYVSLTGVIVYLMISPYY*" gene complement(2086070..2086606) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" downshifts complement(2086093) /Source="Nicolas_upshifts" /id="D1050" /incds=0 /nref=175 /ntot=250 /MaxReadThrough="4.33842" /MaxDrop="7.96098" /score="14.7470642" /energy="-7.7" /TU="U1556" /idTUdmin="U1557" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(2086633..2086652) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2086653) /Source="Nicolas_upshifts" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" promotor_-35 complement(2086666..2086673) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2086743..2087525) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389796.1" /db_xref="EnsemblGenomes-Gn:BSU19150" /db_xref="EnsemblGenomes-Tr:CAB13807" /db_xref="SubtiList:BG13515" /db_xref="UniProtKB/Swiss-Prot:O34516" /translation="MAIDSLINKLQYVQLEPPDKILSLYLNTDMRDPEQQGGEWKIAL KSGFSRLKEYLAASDPEEEKCLDGIRAKMNQYLNAMGKDMPRSLVFFVSDSGIWEPIK LQVPVDTRFYWEETAVLDQLKGLRQTYPSTAFILTQQHEVKIIETVLGKIEAVERYEY DMINESWKNSHSAVDKAPPFEENRMREHVTENQSRLYKRLAASLDQKAAAKRWERMVI AGDKETADILDQHMNKPIHSKIQKNLLNENEHKVIEHLIKEA*" gene complement(2086743..2087525) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" downshifts complement(2086752) /Source="Nicolas_upshifts" /id="D1051" /incds=0 /nref=3 /ntot=38 /MaxReadThrough="5.37496" /MaxDrop="4.00348" /score="14.7470642" /energy="-7.7" /TU="U1557" /idTUdmin="U1557" /TUdmin="-660" /isTUend="FALSE" promotor_-10 complement(2087547..2087565) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2087566) /Source="Nicolas_upshifts" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" promotor_-35 complement(2087579..2087585) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2087622..2087629 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 2087644..2087663 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 2087648 /Source="Nicolas_upshifts" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" CDS 2087696..2088193 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389797.1" /db_xref="EnsemblGenomes-Gn:BSU19160" /db_xref="EnsemblGenomes-Tr:CAB13808" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13516" /db_xref="UniProtKB/Swiss-Prot:O35042" /translation="MFTVKEKNRQELEEELNDLEFQIYRMQENMKDLSKDAKVLGIDQ SKHDEWMIVSSIDDGQTCKIMLTDCKTAYRGKGCFSLVASYKDDAIHIGDIKGPPNHG FGSICMKYLKDIARDHNIPKVTGDIAKRDWNHVDRLIHFYEKHHFKVCIDHDTQSGSI KWVDL*" gene 2087696..2088193 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" promotor_-35 2088200..2088203 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 2088219..2088238 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 2088221 /Source="Nicolas_upshifts" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" CDS 2088257..2089234 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" /EC_number="3.4.17.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22516613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxypeptidase; aminoacid adenylate hydrolase (microcin resistance)" /protein_id="NP_389798.1" /db_xref="EnsemblGenomes-Gn:BSU19170" /db_xref="EnsemblGenomes-Tr:CAB13809" /db_xref="GOA:O35046" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13517" /db_xref="UniProtKB/Swiss-Prot:O35046" /translation="MYASKLKKGDEIRIVSPATSMSILSNEAKIQAKTALERLGYRVT IAEHANECNEFDSSSIESRVHDLHAAFFDPGVKAILTTLGGFNSNQLLRYLDYEKIKR HPKILCGYSDITALCNAIYQKTGLVTYSGPHFSTFAMKKGLDYTEEYFLSCCASDDPF EIHPSSEWSDDRWFLDQENRRFYPNNGPVVIQEGYAEGTLIGGNLCTLNLLQGTEYFP ETEHTILLIEDDYMSDIHMFDRDLQSLIHLPAFSHVKAILIGRFQKASNVSIDLVKAM IETKKELSGIPIIANINAGHTSPIATFPIGGTCRIEAISGTSRIWIDKH*" gene 2088257..2089234 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" downshifts 2089206 /Source="Nicolas_upshifts" /id="D1052" /incds=0 /nref=131 /ntot=256 /MaxReadThrough="3.77491" /MaxDrop="4.2254" /score="1.66373432" /energy="-9.5" /TU="U1558,U1559" /idTUdmin="U1558" /TUdmin="-132" /isTUend="FALSE" promotor_-35 2089331..2089338 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2089353..2089372 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2089360 /Source="Nicolas_upshifts" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" CDS 2089396..2090454 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" /EC_number="1.14.19.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid desaturase" /protein_id="NP_389799.1" /db_xref="EnsemblGenomes-Gn:BSU19180" /db_xref="EnsemblGenomes-Tr:CAB13810" /db_xref="GOA:O34653" /db_xref="InterPro:IPR005804" /db_xref="SubtiList:BG13518" /db_xref="UniProtKB/Swiss-Prot:O34653" /translation="MTEQTIAHKQKQLTKQVAAFAQPETKNSLIQLLNTFIPFFGLWF LAYLSLDVSYLLTLALTVIAAGFLTRIFIIFHDCCHQSFFKQKRYNHILGFLTGVLTL FPYLQWQHSHSIHHATSSNLDKRGTGDIWMLTVNEYKAASRRTKLAYRLYRNPFIMFI LGPIYVFLITNRFNKKGARRKERVNTYLTNLAIVALAAACCLIFGWQSFLLVQGPIFL ISGSIGVWLFYVQHTFEDSYFEADENWSYVQAAVEGSSFYKLPKLLQWLTGNIGYHHV HHLSPKVPNYKLEVAHEHHEPLKNVPTITLKTSLQSLAFRLWDEDNKQFVSFRAIKHI PVSLPPDSPEKQKLRKNA*" gene 2089396..2090454 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" S_feature 2090455..2090524 /Source="Nicolas_S_feature" /locus_tag="new_2090455_2090524" /HighExp="Cold, S8, LoTm, Sw, Paraq, BC, S7, S0, Oxctl, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.859" /TUlongSig="SigA, SigA" /TUlongPSig="0.984, 1" /label="S730" promotor_-35 2090508..2090514 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2090526..2090545 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2090526 /Source="Nicolas_upshifts" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" CDS 2090574..2091686 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component thermosensor histidine kinase [DesR-DesK]" /protein_id="NP_389800.1" /db_xref="EnsemblGenomes-Gn:BSU19190" /db_xref="EnsemblGenomes-Tr:CAB13811" /db_xref="GOA:O34757" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="PDB:3EHF" /db_xref="PDB:3EHG" /db_xref="PDB:3EHH" /db_xref="PDB:3EHJ" /db_xref="PDB:3GIE" /db_xref="PDB:3GIF" /db_xref="PDB:3GIG" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUM" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13519" /db_xref="UniProtKB/Swiss-Prot:O34757" /translation="MIKNHFTFQKLNGITPYIWTIFFILPFYFIWKSSSTFVIIVGII LTLLFFSVYRFAFVSKGWTIYLWGFLLIGISTASITLFSYIYFAFFIAYFIGNIKERV PFHILYYVHLISAAVAANFSLVLKKEFFLTQIPFVVITLISAILLPFSIKSRKERERL EEKLEDANERIAELVKLEERQRIARDLHDTLGQKLSLIGLKSDLARKLIYKDPEQAAR ELKSVQQTARTSLNEVRKIVSSMKGIRLKDELINIKQILEAADIMFIYEEEKWPENIS LLNENILSMCLKEAVTNVVKHSQAKTCRVDIQQLWKEVVITVSDDGTFKGEENSFSKG HGLLGMRERLEFANGSLHIDTENGTKLTMAIPNNSK*" gene 2090574..2091686 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" CDS 2091705..2092304 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [DesK]" /protein_id="NP_389801.1" /db_xref="EnsemblGenomes-Gn:BSU19200" /db_xref="EnsemblGenomes-Tr:CAB13812" /db_xref="GOA:O34723" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:4LDZ" /db_xref="PDB:4LE0" /db_xref="PDB:4LE1" /db_xref="PDB:4LE2" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13520" /db_xref="UniProtKB/Swiss-Prot:O34723" /translation="MISIFIAEDQQMLLGALGSLLNLEDDMEVVGKGTTGQDAVDFVK KRQPDVCIMDIEMPGKTGLEAAEELKDTGCKIIILTTFARPGYFQRAIKAGVKGYLLK DSPSEELANAIRSVMNGKRIYAPELMEDLYSEANPLTDREKEVLELVADGKNTKEIAQ ELSIKSGTVRNYISMILEKLEVKNRIEAITRSKEKGWFK*" gene 2091705..2092304 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" downshifts 2092242 /Source="Nicolas_upshifts" /id="D1053" /incds=1 /nref=1 /ntot=41 /MaxReadThrough="4.44811" /MaxDrop="2.78724" /score="23.648858" /energy="-15.4" /TU="U1560" /idTUdmin="U1560" /TUdmin="-44" /isTUend="FALSE" downshifts 2092286 /Source="Nicolas_upshifts" /id="D1054" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.88273" /MaxDrop="3.38398" /score="23.648858" /energy="-15.4" /TU="NA" /idTUdmin="U1560" /TUdmin=0 /isTUend="TRUE" S_feature complement(2092326..2092824) /Source="Nicolas_S_feature" /locus_tag="new_2092326_2092824_c" /HighExp="S4, LoTm, S6, S3, S5, S8, S7, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.230296" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S731" downshifts complement(2092362) /Source="Nicolas_upshifts" /id="D1055" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.62146" /MaxDrop="5.61121" /score="23.7393309" /energy="-12.4" /TU="NA" /idTUdmin="U1563" /TUdmin=0 /isTUend="TRUE" promotor_-35 2092796..2092805 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2092808..2092826) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2092817..2093011 /Source="Nicolas_S_feature" /locus_tag="new_2092817_2093011" /HighExp="S6, S8, S7, BT, B36, Pyr, G/S, C30, S5, B60" /AntisenseName="yocH" /AntisenseCor="0.113870403460631" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S732" upshifts 2092817 /Source="Nicolas_upshifts" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" promotor_-10 2092818..2092837 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2092824) /Source="Nicolas_upshifts" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" promotor_-35 complement(2092843..2092848) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2092899..2093762) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" /EC_number="3.2.1.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:17307850, 20070526, 20487291, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17307850, 20070526, 20487291, 26102633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported cell wall lytic enzyme" /protein_id="NP_389802.1" /db_xref="EnsemblGenomes-Gn:BSU19210" /db_xref="EnsemblGenomes-Tr:CAB13813" /db_xref="GOA:O34669" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG13521" /db_xref="UniProtKB/Swiss-Prot:O34669" /translation="MKKTIMSFVAVAALSTTAFGAHASAKEITVQKGDTLWGISQKNG VNLKDLKEWNKLTSDKIIAGEKLTISSEETTTTGQYTIKAGDTLSKIAQKFGTTVNNL KVWNNLSSDMIYAGSTLSVKGQATAANTATENAQTNAPQAAPKQEAVQKEQPKQEAVQ QQPKQETKAEAETSVNTEEKAVQSNTNNQEASKELTVTATAYTANDGGISGVTATGID LNKNPNAKVIAVDPNVIPLGSKVYVEGYGEATAADTGGAIKGNKIDVFVPSKSDASNW GVKTVSVKVLN*" gene complement(2092899..2093762) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" downshifts complement(2092912) /Source="Nicolas_upshifts" /id="D1056" /incds=0 /nref=227 /ntot=262 /MaxReadThrough="2.55593" /MaxDrop="7.59881" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-22" /isTUend="TRUE" downshifts 2092968 /Source="Nicolas_upshifts" /id="D1057" /incds=1 /nref=8 /ntot=28 /MaxReadThrough="6.14664" /MaxDrop="3.95582" /score="23.648858" /energy="-15.4" /TU="U1562" /idTUdmin="U1560" /TUdmin=682 /isTUend="FALSE" downshifts complement(2093000) /Source="Nicolas_upshifts" /id="D1058" /incds=1 /nref=10 /ntot=161 /MaxReadThrough="7.34609" /MaxDrop="3.8459" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-110" /isTUend="FALSE" S_feature 2093013..2093780 /Source="Nicolas_S_feature" /locus_tag="new_2093013_2093780" /HighExp="BT, S8, S6, Gly, S7, C30, G135, G/S, Fru, Pyr" /AntisenseName="yocH" /AntisenseCor="-0.12155468325348801" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S733" promotor_-35 2093758..2093762 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2093771..2093785 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2093782 /Source="Nicolas_upshifts" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2093801..2093820) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2093814) /Source="Nicolas_upshifts" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" S_feature complement(2093816..2094009) /Source="Nicolas_S_feature" /locus_tag="new_2093816_2094009_c" /HighExp="LoTm, HiOs, S8, C30, S2, G135, G180, T5.0H, S7, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S734" promotor_-35 complement(2093832..2093838) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2094010..2095785) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" /EC_number="3.6.1.12" /experiment="publication(s) with functional evidences, PMID:11886746, 16385024, 22200572, 25246477, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 16385024, 22200572, 25246477, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase" /protein_id="NP_389803.1" /db_xref="EnsemblGenomes-Gn:BSU19220" /db_xref="EnsemblGenomes-Tr:CAB13814" /db_xref="GOA:O34748" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002121" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR006293" /db_xref="InterPro:IPR010997" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018982" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032284" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13522" /db_xref="UniProtKB/Swiss-Prot:O34748" /translation="MLHRAQSLLAHYFGYEKFRSGQDEAIRLVTEARQNTACIMPTGG GKSICYQIPALMFEGTTIVISPLISLMKDQVDALEEAGINAAYINSTQSNQEIYERLN GLKEGAYKLFYITPERLTSIEFIRILQGIDVPLVAIDEAHCISQWGHDFRPSYRNIEI LFRELHDKPVIMALTATATPEVHDDICKQLHIQKENTVYTGFSRENLTFKVVKGENKD RFIDEYVQNNRHEAGIVYTATRKEADRIYERLKRNQVRAGRYHGGLADDVRKEQQERF LNDELQVMVATSAFGMGIDKSNIRFVLHAQIPKDMESYYQEAGRAGRDGLASECVLLF SPQDIMVQRFLIEQSEHEEKQKQDLKKLRQMVDYCHTEDCLQRFILMYFGEKEPDACG QCGNCTDTRAAHDVTREAQMVLSCIIRMKERFGKTMVAQVLAGSKNKKVLENGFSDLS TYGILKHQSVGEISDFIEFLISDDFIRMSDGTFPTLFVSSKGRNVLKGELSVARKEAL KAAAITENDELFERLRMVRKEIAAEQGVPPFVVFSDQTLKEMSGKQPVNDDELLSIKG VGEQKRAKYGRLFLQEIQAYARMTD*" gene complement(2094010..2095785) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" S_feature complement(2095786..2095916) /Source="Nicolas_S_feature" /locus_tag="new_2095786_2095916_c" /HighExp="LoTm, G180, Cold, G135, G150, T5.0H, T4.0H, T3.30H, S2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S735" misc_RNA complement(2095909..2096111) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" /product="6Sa RNA" /experiment="publication(s) with functional evidences, PMID:11886746, 15793584, 15811922, 22333917, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 15793584, 15811922, 22333917, 25576829, 26873600; Product type n : RNA" gene complement(2095909..2096111) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" downshifts complement(2095961) /Source="Nicolas_upshifts" /id="D1059" /incds=0 /nref=34 /ntot=297 /MaxReadThrough="4.06142" /MaxDrop="7.97725" /score="26.8190437" /energy="-12.7" /TU="U1566" /idTUdmin="U1568" /TUdmin=163 /isTUend="FALSE" promotor_-10 complement(2096109..2096128) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-10" upshifts complement(2096127) /Source="Nicolas_upshifts" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" S_feature complement(2096129..2096321) /Source="Nicolas_S_feature" /locus_tag="new_2096129_2096321_c" /HighExp="dia5, Etha, dia15, Diami, S8, S7, C30, G180, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S736" promotor_-35 complement(2096141..2096148) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-35" CDS complement(2096350..2096976) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" /EC_number="1.7.-.-" /experiment="publication(s) with functional evidences, PMID:11886746, 18208493, 22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 18208493, 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-dependent NADH-azoreductase" /protein_id="NP_389804.1" /db_xref="EnsemblGenomes-Gn:BSU19230" /db_xref="EnsemblGenomes-Tr:CAB13815" /db_xref="GOA:O35022" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13523" /db_xref="UniProtKB/Swiss-Prot:O35022" /translation="MSTVLFVKSSDRTAEEGVSTKLYEAFLAAYKENNPNDEVVELDL HKENLPYLGRDMINGTFKAGQGMEMTEDEKKQAAIADKYLNQFVKADKVVFAFPLWNF TVPAVLHTYVDYLSRAGVTFKYTQEGPVGLMGGKKVALLNARGGVYSEGPMAALEMSL NFMKTVLGFWGVQDLHTVVIEGHNAAPDQAQEIVEKGLQEAKDLAAKF*" gene complement(2096350..2096976) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" downshifts complement(2096366) /Source="Nicolas_upshifts" /id="D1060" /incds=0 /nref=68 /ntot=205 /MaxReadThrough="5.10353" /MaxDrop="5.66408" /score="1.15982687" /energy="-10.9" /TU="U1567,U1568" /idTUdmin="U1567" /TUdmin="-220" /isTUend="FALSE" promotor_-10 complement(2097010..2097029) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-10" upshifts complement(2097023) /Source="Nicolas_upshifts" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" promotor_-35 complement(2097043..2097050) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-35" CDS complement(2097126..2097617) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 15496987, 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_389805.2" /db_xref="EnsemblGenomes-Gn:BSU19240" /db_xref="EnsemblGenomes-Tr:CAB13816" /db_xref="GOA:P80872" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR020458" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG13524" /db_xref="UniProtKB/Swiss-Prot:P80872" /translation="MALTKEQTQHLYHKLLDMQKELSGEKKETESMTEEVGELSNGVD NHMADHGTLVTDRMTDQTVKEIDRELLEEVNRALQKMKDGTYGVCEKTGQEIPYERLE AVPYARMTVEAQADVEDDLETDAPSYEREFHEQVKDLSNKETIDQKSSQTYEILDREQ DSK*" gene complement(2097126..2097617) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" downshifts complement(2097135) /Source="Nicolas_upshifts" /id="D1061" /incds=0 /nref=5 /ntot=49 /MaxReadThrough="7.79466" /MaxDrop="4.30433" /score="1.15982687" /energy="-10.9" /TU="U1568,U1573" /idTUdmin="U1571" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2097629..2097647) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-10" upshifts complement(2097641) /Source="Nicolas_upshifts" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" promotor_-35 complement(2097661..2097667) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-35" CDS complement(2097692..2098024) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389806.1" /db_xref="EnsemblGenomes-Gn:BSU19250" /db_xref="EnsemblGenomes-Tr:CAB13817" /db_xref="SubtiList:BG13525" /db_xref="UniProtKB/Swiss-Prot:O34976" /translation="MKKMFRSLIRHCLKPELDKLRECEERLSVIEKQKQSSKQESEET YIHIETLNVEKVDYHLEFGELTIDELSGRLNIGATYYIPPEEKDKKCQRKPEAPSTPA VTIRSKRQ*" gene complement(2097692..2098024) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" S_feature complement(2098025..2098315) /Source="Nicolas_S_feature" /locus_tag="new_2098025_2098315_c" /HighExp="Salt, Cold, S3, S8, S4, S7, T5.0H, T3.30H, S6, T4.0H" /AntisenseName="yoyB" /AntisenseCor="0.489341986454357" /AntisenseRegPval="-16.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S737" promotor_-35 2098040..2098045 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-35" promotor_-10 2098060..2098078 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-10" upshifts 2098062 /Source="Nicolas_upshifts" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" CDS 2098102..2098329 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097740.1" /db_xref="EnsemblGenomes-Gn:BSU19259" /db_xref="EnsemblGenomes-Tr:CAX52637" /db_xref="UniProtKB/Swiss-Prot:C0H429" /translation="MLPTNINISHLKTNSIGTGSSLTFGSAELRNRCSAIKRNNGFGE QNADGIVMVIPIESIDDRDVSDALSMKINHQ*" gene 2098102..2098329 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" CDS complement(2098316..2098792) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11150673, 23155385; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_389808.1" /db_xref="EnsemblGenomes-Gn:BSU19260" /db_xref="EnsemblGenomes-Tr:CAB13818" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG13526" /db_xref="UniProtKB/Swiss-Prot:O34321" /translation="MDFEKMKQWMEFAQQMYGGDFWKQVFDEDQKTPFMTNGQSPFPF AQQDQRGKGDASFPSMDIVDTVAEVQFLIYLPGYRKQDVHILSYGDYLVVKGQRFSYF NEQDFRQKEGKYGSFEKKIPLSDHLHGKMNAIFKDGILYITIQKDEGQAKTIVIDD*" gene complement(2098316..2098792) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" S_feature 2098330..2098837 /Source="Nicolas_S_feature" /locus_tag="new_2098330_2098837" /HighExp="S6, S5, S8, S7, S4, B36, BT, S3, T5.0H, LoTm" /AntisenseName="yocM" /AntisenseCor="0.54530996552252997" /AntisenseRegPval="-21.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.877" /TUlongSig="NA" /TUlongPSig="NA" /label="S738" S_feature complement(2098793..2098895) /Source="Nicolas_S_feature" /locus_tag="new_2098793_2098895_c" /HighExp="Cold, Salt, S8, T5.0H, S3, T-0.40H, T0.0H, S4, T4.0H, S6" /AntisenseName="yozN" /AntisenseCor="0.471443110130365" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S739" promotor_-35 2098810..2098815 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2098830..2098848 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2098839 /Source="Nicolas_upshifts" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" CDS 2098859..2099122 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (mother cell in sporulation)" /protein_id="NP_389809.1" /db_xref="EnsemblGenomes-Gn:BSU19270" /db_xref="EnsemblGenomes-Tr:CAB13819" /db_xref="SubtiList:BG13761" /db_xref="UniProtKB/Swiss-Prot:O31846" /translation="MVQPTPYININIFMLKINSFENASAVNVGQNLLAEWQNSDKKNQ GYGQNFGDASGFMGTRSHVDDRDQIDSPASFESEAVNSSIKRK*" gene 2098859..2099122 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" promotor_-10 complement(2098875..2098894) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2098895) /Source="Nicolas_upshifts" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" S_feature complement(2098897..2099422) /Source="Nicolas_S_feature" /locus_tag="new_2098897_2099422_c" /HighExp="Salt, Cold, T-0.40H, T0.0H, T0.30H, T-1.10H, T-1.40H, T3.30H, T2.0H, S0" /AntisenseName="yocN" /AntisenseCor="-0.51964820699949898" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S740" promotor_-35 complement(2098908..2098912) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2099127..2099360 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (sporulation-related)" /protein_id="NP_389810.1" /db_xref="EnsemblGenomes-Gn:BSU19280" /db_xref="EnsemblGenomes-Tr:CAB13820" /db_xref="SubtiList:BG13527" /db_xref="UniProtKB/Swiss-Prot:O34855" /translation="MFFSPSVVNVGGFKINTMDRGSSLTLGPYQQVDYFLSAKINQGF GEENGDFTPLVVPISNVLDADLVDSNSAKNSVV*" gene 2099127..2099360 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" downshifts 2099347 /Source="Nicolas_upshifts" /id="D1062" /incds=0 /nref=62 /ntot=90 /MaxReadThrough="2.0117" /MaxDrop="7.59451" /score="5.68120132" /energy="-10.9" /TU="NA" /idTUdmin="U1570" /TUdmin=0 /isTUend="TRUE" CDS complement(2099446..2099790) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved hypothetical phage protein" /protein_id="NP_389811.1" /db_xref="EnsemblGenomes-Gn:BSU19290" /db_xref="EnsemblGenomes-Tr:CAB13821" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG13762" /db_xref="UniProtKB/Swiss-Prot:O31847" /translation="MGIFSVSRSTDAKKLEALLVEGERIESIYKLRVDQICFTNKRII FFDNKMFSKKKVRVFLPYKTIESFAIQEAGMFDPDTGLLLMTRSKTFELEFAKDTDLS EVQAVLTKHLCS*" gene complement(2099446..2099790) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" downshifts complement(2099467) /Source="Nicolas_upshifts" /id="D1063" /incds=0 /nref=61 /ntot=217 /MaxReadThrough="4.58642" /MaxDrop="4.1868" /score="12.6520239" /energy="-9.6" /TU="U1572,U1573" /idTUdmin="U1574" /TUdmin=616 /isTUend="FALSE" S_feature complement(2099791..2099863) /Source="Nicolas_S_feature" /locus_tag="new_2099791_2099863_c" /HighExp="T0.30H, T0.0H, T1.0H, T-0.40H, T1.30H, T-1.10H, Salt, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S741" promotor_-10 complement(2099859..2099878) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2099863) /Source="Nicolas_upshifts" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" S_feature complement(2099865..2099968) /Source="Nicolas_S_feature" /locus_tag="new_2099865_2099968_c" /HighExp="T0.30H, T0.0H, T-0.40H, T1.0H, T1.30H, Salt, T-1.10H, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S742" promotor_-35 complement(2099892..2099897) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2099955..2099970) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2099968) /Source="Nicolas_upshifts" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" promotor_-35 complement(2099983..2099992) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2100111) /Source="Nicolas_upshifts" /id="D1064" /incds=0 /nref=117 /ntot=269 /MaxReadThrough="5.5406" /MaxDrop="6.72115" /score="36.7697843" /energy="-10.7" /TU="U1574" /idTUdmin="U1576" /TUdmin="-6" /isTUend="TRUE" CDS complement(2100147..2100350) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389812.1" /db_xref="EnsemblGenomes-Gn:BSU19300" /db_xref="EnsemblGenomes-Tr:CAB13822" /db_xref="SubtiList:BG13750" /db_xref="UniProtKB/Swiss-Prot:O31848" /translation="MIHKNWLEKETIKKVKCVQTNAKKYIVNRVLTPGKEYEVKNETE EFLFVVDNTNKVGGYYKEYFEEM*" gene complement(2100147..2100350) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" promotor_-10 complement(2100371..2100390) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2100389) /Source="Nicolas_upshifts" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" S_feature complement(2100391..2100457) /Source="Nicolas_S_feature" /locus_tag="new_2100391_2100457_c" /HighExp="S7, S8, S6, S5, C30, S4, T4.0H, B60, BC, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.461" /TUlongSig="NA" /TUlongPSig="NA" /label="S743" promotor_-35 complement(2100406..2100413) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2100423..2100430 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-35" upshifts 2100442 /Source="Nicolas_upshifts" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" misc_feature complement(2100444..2100456) /Source="Nicolas_upshift_promotors" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 2100444..2100463 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-10" S_feature 2100447..2100579 /Source="Nicolas_S_feature" /locus_tag="new_2100447_2100579" /HighExp="BC, M0t90, M9-stat, S2, T2.30H, Sw, Lbstat, M40t90, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S744" upshifts complement(2100468) /Source="Nicolas_upshifts" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" CDS 2100580..2102067 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" /EC_number="1.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17555270, 23874669, 25409630, 26337367, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17555270, 23874669, 25409630, 26337367, 27797724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxypropionaldehyde dehydrogenase" /protein_id="NP_389813.1" /db_xref="EnsemblGenomes-Gn:BSU19310" /db_xref="EnsemblGenomes-Tr:CAB13823" /db_xref="GOA:O34660" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12582" /db_xref="UniProtKB/Swiss-Prot:O34660" /translation="MSSLTMQVTKRLETFLQGTKKLYIDGKFVPSASGATFDTPNPAT GETLMTLYEAQAADVDKAVKAARKAFDQGEWRTMSPASRSRLMYKLADLMEEHKTELA QLETLDNGKPINETTNGDIPLAIEHMRYYAGWCTKITGQTIPVSGAYFNYTRHEPVGV VGQIIPWNFPLLMAMWKMGAALATGCTIVLKPAEQTPLSALYLAELIDQAGFPAGVIN IIPGFGEDAGEALTNHEAVDKIAFTGSTEIGKKIMSTAAKSIKRVTLELGGKSPNILL PDANLKKAIPGALNGVMFNQGQVCCAGSRVFIHKDQYDEVVDEMASYAESLRQGAGLH KDTQIGPLVSKEQHERVLSYIQKGKDEGAKAVTGGSCPFEAGYFVAPTVFANVEDEMT IAKEEIFGPVLTAIPYETVDEVIERANHSEYGLAAGLWTENVKQAHYIADRLQAGTVW VNCYNVFDAASPFGGYKQSGLGREMGSYALDNYTEVKSVWVNLED*" gene 2100580..2102067 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" promotor_-10 complement(2101023..2101040) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2101029) /Source="Nicolas_upshifts" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2101053..2101061) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2102053 /Source="Nicolas_upshifts" /id="D1065" /incds=0 /nref=163 /ntot=260 /MaxReadThrough="3.66831" /MaxDrop="7.01026" /score="24.6079855" /energy="-7.1" /TU="U1575" /idTUdmin="U1575" /TUdmin="-1144" /isTUend="FALSE" promotor_-35 2102115..2102120 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2102136..2102154 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2102141 /Source="Nicolas_upshifts" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" CDS 2102168..2104066 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" /EC_number="4.2.1.137" /EC_number="5.4.99.17" /function="16.13: Shape" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2253626, 18436644, 18630919, 21627333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2253626, 18436644, 18630919, 21627333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="squalene-hopene cyclase, sporulenol synthase (spore protection)" /protein_id="NP_389814.2" /db_xref="EnsemblGenomes-Gn:BSU19320" /db_xref="EnsemblGenomes-Tr:CAB13824" /db_xref="GOA:Q796C3" /db_xref="InterPro:IPR008930" /db_xref="InterPro:IPR018333" /db_xref="InterPro:IPR032696" /db_xref="InterPro:IPR032697" /db_xref="SubtiList:BG12679" /db_xref="UniProtKB/Swiss-Prot:Q796C3" /translation="MGTLQEKVRRFQKKTITELRDRQNADGSWTFCFEGPIMTNSFFI LLLTSLDEGENEKELISSLAAGIHAKQQPDGTFINYPDETRGNLTATVQGYVGMLASG CFHRTEPHMKKAEQFIISHGGLRHVHFMTKWMLAANGLYPWPALYLPLSLMALPPTLP IHFYQFSSYARIHFAPMAVTLNQRFVLINRNISSLHHLDPHMTKNPFTWLRSDAFEER DLTSILLHWKRVFHAPFAFQQLGLQTAKTYMLDRIEKDGTLYSYASATIYMVYSLLSL GVSRYSPIIRRAITGIKSLVTKCNGIPYLENSTSTVWDTALISYALQKNGVTETDGSV TKAADFLLERQHTKIADWSVKNPNSVPGGWGFSNINTNNPDCDDTTAVLKAIPRNHSP AAWERGVSWLLSMQNNDGGFSAFEKNVNHPLIRLLPLESAEDAAVDPSTADLTGRVLH FLGEKVGFTEKHQHIQRAVKWLFEHQEQNGSWYGRWGVCYIYGTWAALTGMHACGVDR KHPGIQKALRWLKSIQNDDGSWGESCKSAEIKTYVPLHRGTIVQTAWALDALLTYENS EHPSVVKGMQYLTDSSSHSADSLAYPAGIGLPKQFYIRYHSYPYVFSLLAVGKYLDSI EKETANET*" gene 2102168..2104066 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" promotor_-10 complement(2103111..2103130) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2103119) /Source="Nicolas_upshifts" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2103144..2103153) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2104056..2104901 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" /EC_number="1.15.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 20233928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Fe2+-dependent)" /protein_id="NP_389815.1" /db_xref="EnsemblGenomes-Gn:BSU19330" /db_xref="EnsemblGenomes-Tr:CAB13825" /db_xref="GOA:O35023" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="SubtiList:BG12676" /db_xref="UniProtKB/Swiss-Prot:O35023" /translation="MKRESYQAEMFNWCEALKDQIQKRGQLDQFEDQIDKMIEALEDD QTTEEDWYKQAAALYRDITESDDTSERRAYVPIGKHVLPKLPYKYSALEPYISRDIMI LHHTKHHQSYVDGLNKAESELKKARATKNYDLITHWERELAFHGAGHYLHSIFWFSMH PNGKRRPTGALFQMIDLSFGSYSAFKEHFTQASKKVEGVGWAILVWAPRSGRLEILTA EKHQLFSQWDVIPLLPLDVWEHAYYLQYKNDRASYVDHWWNVVDWREAEKRFEQAKEV VWKLY*" gene 2104056..2104901 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" S_feature 2104902..2106408 /Source="Nicolas_S_feature" /locus_tag="new_2104902_2106408" /HighExp="S5, S6, S4, S8, S3, S7, T5.0H, B36, BT, T4.0H" /AntisenseName="yocR" /AntisenseCor="-0.62866346519731298" /AntisenseRegPval="-30.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S745" CDS complement(2104934..2106271) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_389816.1" /db_xref="EnsemblGenomes-Gn:BSU19340" /db_xref="EnsemblGenomes-Tr:CAB13826" /db_xref="GOA:O34383" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13528" /db_xref="UniProtKB/Swiss-Prot:O34383" /translation="MKEANQWSSKLGFILAAAGSAIGLGAIWKFPYVAGTSGGGAFLL IFILFTVLIGLPLLLGEFIIGRRTQKDAVQSYKTLAPGTKWHWIGYLGMVTCFILLSF YSVVGGWILIYIIKGFTGGLSQTSGFDTIFASTISNPYLAVGGQLLFMVVTILVVAKG VSSGIEKASQVLMPALFLLFIILMVRSVTLDGAMEGIKFFLMPDLTAIDANTILYAMG QSFFLLSVGVSVMVTYSAYLEKQENLVQSAVSVTVMNMLVAVMAGIAIFPAVFSFGLK PDQGPVLLFNVLPTVFNQMPFGIIFLLAFLLLFLFAALTSAFSMLEILVAVLSKGDIN KRKRFAWLGGIAIFIVGVPSALSYGVLSDVTIFHLSIFDAADYLVSNILMPLGALLIS IFVPLKIPKQDLFDELKSGSNLKRKWFAVWLLLIRYLSPVAIIIVFLHVIGIF*" gene complement(2104934..2106271) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" downshifts complement(2104945) /Source="Nicolas_upshifts" /id="D1066" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="0.83968" /MaxDrop="2.44824" /score="27.8372036" /energy="-11.1" /TU="NA" /idTUdmin="U1580" /TUdmin=154 /isTUend="FALSE" promotor_-10 complement(2106299..2106318) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2106314) /Source="Nicolas_upshifts" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" S_feature complement(2106316..2107474) /Source="Nicolas_S_feature" /locus_tag="new_2106316_2107474_c" /HighExp="M9-stat, T1.30H, B60, T1.0H, T2.0H, T0.30H, T2.30H, T3.0H, T3.30H, Etha" /AntisenseName="yocS" /AntisenseCor="-6.3575129468026695E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S746" promotor_-35 complement(2106333..2106340) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2106392..2106395 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2106410..2106429 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2106410 /Source="Nicolas_upshifts" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" CDS 2106490..2107455 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent symporter" /protein_id="NP_389817.1" /db_xref="EnsemblGenomes-Gn:BSU19350" /db_xref="EnsemblGenomes-Tr:CAB13827" /db_xref="GOA:O34524" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG13529" /db_xref="UniProtKB/Swiss-Prot:O34524" /translation="MDIIRKISHFAGQTFGIWVIVFAVLGFSFPSLFTWISSYITIFL GIIMFGMGLTLQADDFKELVRKPWQVIIGVIAQYTIMPLVAFGLAFGLHLPAEIAVGV ILVGCCPGGTASNVMTFLAKGNTALSVAVTTISTLLAPVVTPLLIMLFAKEWLPVSPG SLFISILQAVLFPIIAGLIVKMFFRKQVAKAVHALPLVSVIGIVAIVSAVVSGNRENL LQSGLLIFSVVILHNGIGYLLGFLCAKLLKMDYPSQKAIAIEVGMQNSGLGAALATAH FSPLSAVPSAIFSVWHNLSGSMLATYWSKKVKKKQAGSKSSNLSL*" gene 2106490..2107455 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" downshifts 2107443 /Source="Nicolas_upshifts" /id="D1067" /incds=0 /nref=42 /ntot=166 /MaxReadThrough="3.53218" /MaxDrop="5.09676" /score="30.279305" /energy="-16.4" /TU="U1581" /idTUdmin="U1581" /TUdmin="-22" /isTUend="TRUE" CDS complement(2107505..2108758) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" /EC_number="2.3.1.61" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417, 22720735, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417, 22720735, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase complex (dihydrolipoamide transsuccinylase, E2 subunit)" /protein_id="NP_389818.2" /db_xref="EnsemblGenomes-Gn:BSU19360" /db_xref="EnsemblGenomes-Tr:CAB13828" /db_xref="GOA:P16263" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR006255" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10273" /db_xref="UniProtKB/Swiss-Prot:P16263" /translation="MAEIKVPELAESISEGTIAQWLKQPGDYVEQGEYLLELETDKVN VELTAEESGVLQEVLKDSGDTVQVGEIIGTISEGAGESSAPAPTEKTESKESVKEEKQ AEPAAQEVSEEAQSEAKSRTIASPSARKLAREKGIDLSQVPTGDPLGRVRKQDVEAYE KPASKPAPQQKQQPQAQKAQQSFDKPVEVQKMSRRRQTIAKRLVEVQQTSAMLTTFNE VDMTAVMNLRKRRKDQFFEQNEVKLGFMSFFTKAVVAALKKYPLLNAEIQGDELIVKK FYDIGIAVAADEGLVVPVVRDADRLTFAGIEKEIGELAKKARNNKLTLSELQGGSFTI TNGGTFGSLMSTPILNSPQVGILGMHKIQLRPVAIDEERFENRPMMYIALSYDHRIVD GKEAVGFLVTIKNLLEDPEQLLLEG*" gene complement(2107505..2108758) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" downshifts complement(2107519) /Source="Nicolas_upshifts" /id="D1068" /incds=0 /nref=200 /ntot=253 /MaxReadThrough="5.25481" /MaxDrop="7.42366" /score="11.7726103" /energy="-16.4" /TU="U1582" /idTUdmin="U1582" /TUdmin="-1694" /isTUend="FALSE" CDS complement(2108774..2111608) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" /EC_number="1.2.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase (E1 subunit)" /protein_id="NP_389819.3" /db_xref="EnsemblGenomes-Gn:BSU19370" /db_xref="EnsemblGenomes-Tr:CAB13829" /db_xref="GOA:P23129" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR011603" /db_xref="InterPro:IPR023784" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR031717" /db_xref="InterPro:IPR032106" /db_xref="SubtiList:BG10272" /db_xref="UniProtKB/Swiss-Prot:P23129" /translation="MFQNSMKQRMNWEDFYGPNLGYALELYDQYTQDPNSIDPDLKEM FDELGAPPSDIKEASGTKEKGRVTADLIQKIASAVRLAEDIRTYGHLNASVNPLRKDE KKSELFPLSDYGLTEEEIKAIPASVICKDAPKNISNGLEAIQYLRNTYKRTISFEFDH VHDFKEREWLTRKIESGELFQKNSAEKLSAVLERLTEVEGFEQFLHRTFVGQKRFSIE GLDALVPVLDDIIAQSVKSGTTSVNIGMAHRGRLNVLAHVLGKPYEIIFSEFQHAPNK DLVPSEGSIGISYGWTGDVKYHLGANRELQDAETKSARITLANNPSHLEFINPIVEGS TRAAQETRTQSGYPVQDETKSLAILIHGDAAFPGEGIVAETLNLSSLKGYQVGGAIHI IANNMIGFTTESAESRSTKYASDLAKGYEIPIVHVNADDPEACLSAVKFAVEYRKTFN KDFLIDLIGYRRYGHNEMDEPSTTQPMLYDAVRKHPTVKQIFAEKLVKEGVVTEEVVQ NIEKSVTKRIEDAYQKVPSKKEHTACEIELPEPVSNGFPDVDTSIDFDVLRKLNGELI NWPESFNVFGKLKRILERRAKAFDDDRKVEWSLAESLAFASILKDGTPIRLTGQDSER GTFAQRNLVLHDSETGKEFVPLHHLSDCSTSFAVHNSPLSEGSVLGFEYGYNVHSPET LVLWEAQYGDFANAAQVYFDQFISAGRAKWGQKSGLVMLLPHGYEGQGPEHSSGRIER FLQLAAENNWTVANLTSAAQYFHILRRQAKMLLREEIRPLVIMTPKSLLRNPNTVSEV QELSESRFQPVYEQSGLSHDYEKVTRLVLSSGKVSIDISDHFNKLEDGKEWLHIARIE QLYPFPAKGVKELFAKLPNLKEIVWVQEEPQNMGAWGYISPYLTEIAPEGVSVQYIGR RRRSSPAEGDPTVHKKEQERIVSDSLTRKN*" gene complement(2108774..2111608) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" promotor_-10 complement(2111703..2111722) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2111718) /Source="Nicolas_upshifts" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" S_feature complement(2111720..2111836) /Source="Nicolas_S_feature" /locus_tag="new_2111720_2111836_c" /HighExp="dia15, G150, G135, H2O2, Lbexp, dia0, Oxctl, LBGtran, G180, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S747" promotor_-35 complement(2111737..2111744) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2111837..2113753) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23087684; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative activator of nitric oxide reductase" /protein_id="NP_389820.2" /db_xref="EnsemblGenomes-Gn:BSU19380" /db_xref="EnsemblGenomes-Tr:CAB13830" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG13567" /db_xref="UniProtKB/Swiss-Prot:O31849" /translation="MKFIKFNDSTIDSFLFMMLTDLAKTLTKSEAVEVEYGVQSYYNP FEKKIYMSHFWKDRAAEDMEAGLKSDVYLRSVGTRYSSLHEFANFLNDIHRHLTFKSF AKQLFMLLEDIRIEECIKRERPGTKHVFAKRKDMYRKHFSTQLTLNLERSIFTDALFC AIYFKLTAESPLETLPSMREDIDLMRPFIEQQLLRVYEADSTRQVLKIVEDLMDGLEE VLDKDMLNTYFFLPELDYAKAAEQPLFEEEKKAPKLSDDITLPKQSDGDEDIHEEEMP TWHRETEAPSKSFLQFDIEHGAKSDLGKDASREGDDGDQALGSVQGSARQTKRKDYSK LEALESQKDQPNGAGMADGKENKYAFPIYKEPQPATSEEELSYKQQAKTIESYQKRLK QMIQKTLEHKKTLPRTDLHAGRLNNKLLRYFTERNPRLFYKKQEPSSEIDAVFTLLVD CSASMFDKMDETKRGIVLFHEALKSVAVPHQIVGFWEDTNDATEKSQPNYFNTVIPFQ SSLRQDSGPAIMQLEPEEDNRDGYAIRQMTKKMLHRSEAQKFLIVFSDGEPAAFGYEQ NGIVDTSEAVIEARKRGIEVINVFLSNSEIEESQMKTIQDMYGKFSIFVPDVDQLPDV LYPLLKKLLHKSIG*" gene complement(2111837..2113753) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" CDS complement(2113764..2114678) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15491156, 23087684; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nitric-oxide reductase associated protein" /protein_id="NP_389821.1" /db_xref="EnsemblGenomes-Gn:BSU19390" /db_xref="EnsemblGenomes-Tr:CAB13831" /db_xref="GOA:O31850" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011704" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13566" /db_xref="UniProtKB/Swiss-Prot:O31850" /translation="MNRKGNLSMTTQLQHLTLPEDIQQKLLSYKEQPISPEFQSLIGT SGYEAEDEAILFDAIIALAMGKNVLLKGPTGSGKTKLAETLSSYFHKPMHSVNCSVDL DAEALVGYKTIENQSGQATIEFVSGPVTKAMKEGHFLYIDEINMAKPETLPILNGVLD YRKMMTNPFTGEVIRAKSGFGVIAAINEGYVGTVPLNEALKNRFVIIDVPYIKGELLK QVLMSQSALKDEKLIDRFITLSSDLIVQANNGQVSEEAASIRALIDTCDLAAYIPPRR AIERGIVEKLDDDREKAAVRNIAETLFE*" gene complement(2113764..2114678) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" promotor_-10 complement(2114682..2114701) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-10" upshifts complement(2114697) /Source="Nicolas_upshifts" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" promotor_-35 complement(2114718..2114722) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-35" CDS complement(2114742..2115332) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" /EC_number="1.15.1.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15897454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15897454; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="superoxide dismutase (exported lipoprotein)" /protein_id="NP_389822.1" /db_xref="EnsemblGenomes-Gn:BSU19400" /db_xref="EnsemblGenomes-Tr:CAB13832" /db_xref="GOA:O31851" /db_xref="InterPro:IPR001424" /db_xref="InterPro:IPR024134" /db_xref="InterPro:IPR036423" /db_xref="PDB:1S4I" /db_xref="PDB:1U3N" /db_xref="PDB:1XTL" /db_xref="PDB:1XTM" /db_xref="SubtiList:BG13565" /db_xref="UniProtKB/Swiss-Prot:O31851" /translation="MHRLLLLMMLTALGVAGCGQKKPPDPPNRVPEKKVVETSAFGHH VQLVNREGKAVGFIEIKESDDEGLDIHISANSLRPGASLGFHIYEKGSCVRPDFESAG GPFNPLNKEHGFNNPMGHHAGDLPNLEVGADGKVDVIMNAPDTSLKKGSKLNILDEDG SAFIIHEQADDYLTNPSGNSGARIVCGALLGNNEKQ*" gene complement(2114742..2115332) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" CDS complement(2115425..2116669) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" /EC_number="3.5.1.-" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 22139507" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 22139507; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan hydrolase (cell wall-binding d,l-endopeptidase)" /protein_id="NP_389823.1" /db_xref="EnsemblGenomes-Gn:BSU19410" /db_xref="EnsemblGenomes-Tr:CAB13833" /db_xref="GOA:O31852" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13564" /db_xref="UniProtKB/Swiss-Prot:O31852" /translation="MKKKIVAGLAVSAVVGSSMAAAPAEAKTIKVKSGDSLWKLSRQY DTTISALKSENKLKSTVLYVGQSLKVPESSKKSTTSPSNSSKTSTYTVAYGDSLWMIA KNHKMSVSELKSLNSLSSDLIRPGQKLKIKGTSSSSGSNGSKKNSGSNSSGSSKSTYT VKLGDSLWKIANSLNMTVAELKTLNGLTSDTLYPKQVLKIKGSSSPKNGNSGSKKPSN SNPSKTTTYKVKAGDSLWKIANRLGVTVQSIRDKNNLSSDVLQIGQVLTISGASKSNP SNPTKPTKPKDNSGSNIQIGSKIDRMITEAKKYVGVPYRWGGNTPAGFDCSGFIYYLI NNVSSISRLSTAGYWNVMQKVSQPSVGDFVFFTTYKSGPSHMGIYLGGGDFIHASSSG VDISNLSNSYWKQRYLGARSYF*" gene complement(2115425..2116669) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" downshifts complement(2115427) /Source="Nicolas_upshifts" /id="D1069" /incds=0 /nref=20 /ntot=183 /MaxReadThrough="4.09529" /MaxDrop="3.77828" /score="11.0350171" /energy="-4.7" /TU="U1584,U1585" /idTUdmin="U1585" /TUdmin="-616" /isTUend="FALSE" promotor_-10 complement(2116732..2116750) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2116745) /Source="Nicolas_upshifts" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" S_feature complement(2116747..2116967) /Source="Nicolas_S_feature" /locus_tag="new_2116747_2116967_c" /HighExp="S2, Lbstat, T2.30H, M0t90, HiOs, T3.0H, Etha, M40t90, T3.30H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S748" promotor_-35 complement(2116763..2116770) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2116953..2116971) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2116967) /Source="Nicolas_upshifts" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" promotor_-35 complement(2116983..2116991) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2117051..2118268) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" /EC_number="2.4.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative YDP-glycosyltransferase" /protein_id="NP_389824.2" /db_xref="EnsemblGenomes-Gn:BSU19420" /db_xref="EnsemblGenomes-Tr:CAB13834" /db_xref="GOA:O31853" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="SubtiList:BG13563" /db_xref="UniProtKB/Swiss-Prot:O31853" /translation="MANVLMIGFPGEGHINPSIGVMKELKSRGENITYYAVKEYKEKI TALDIEFREYHDFRGDYFGKNATGDEERDFTEMLCAFLKACKDIATHIYEEVKHESYD YVIYDHHLLAGKVIANMLKLPRFSLCTTFAMNEEFAKEMMGAYMKGSLEDSPHYESYQ QLAETLNADFQAEIKKPFDVFLADGDLTIVFTSRGFQPLAEQFGERYVFVGPSITERA GNNDFPFDQIDNENVLFISMGTIFNNQKQFFNQCLEVCKDFDGKVVLSIGKHIKTSEL NDIPENFIVRPYVPQLEILKRASLFVTHGGMNSTSEGLYFETPLVVIPMGGDQFVVAD QVEKVGAGKVIKKEELSESLLKETIQEVMNNRSYAEKAKEIGQSLKAAGGSKKAADSI LEAVKQKTQSANA*" gene complement(2117051..2118268) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" downshifts complement(2117077) /Source="Nicolas_upshifts" /id="D1070" /incds=0 /nref=14 /ntot=145 /MaxReadThrough="1.49168" /MaxDrop="4.07727" /score="9.41396656" /energy="-14.4" /TU="NA" /idTUdmin="U1586" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2118301..2118320) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2118309) /Source="Nicolas_upshifts" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" promotor_-35 complement(2118334..2118341) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2118504..2119127) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" /EC_number="2.7.7.85" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:21566650, 23192352, 24939848, 27252699, 27790204, 28751888" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21566650, 23192352, 24939848, 27252699, 27790204, 28751888; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore diadenylate cyclase" /protein_id="NP_389825.3" /db_xref="EnsemblGenomes-Gn:BSU19430" /db_xref="EnsemblGenomes-Tr:CAB13835" /db_xref="GOA:O31854" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR019457" /db_xref="InterPro:IPR034693" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG13562" /db_xref="UniProtKB/Swiss-Prot:O31854" /translation="MKAMRYEQISENAFKGKIQVYLEQILGDASLILKTLHEKDQCLL CELDDLGHVFQDMQGIASSFYLQSYIEEFTPAFIELAKAIKALSEHKHGALIVIERAD PVERFIQKGTSLHAEISSSLIESIFFPGNPLHDGALLVRENKLVSAANVLPLTTKEVD IHLGTRHRAALGMSGYTDALVLVVSEETGKMSFAKDGVLYPLISPRT*" gene complement(2118504..2119127) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" S_feature complement(2119128..2119278) /Source="Nicolas_S_feature" /locus_tag="new_2119128_2119278_c" /HighExp="S8, S5, S7, S6, Etha, S4, M9-stat, S3, C30, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S749" promotor_-35 2119154..2119160 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2119166 /Source="Nicolas_upshifts" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" promotor_-10 2119174..2119185 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2119192..2119200 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2119208..2119308 /Source="Nicolas_upshift_promotors" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2119212..2119230 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2119223 /Source="Nicolas_upshifts" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2119261..2119279) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2119268..2119353 /Source="Nicolas_S_feature" /locus_tag="new_2119268_2119353" /HighExp="S8, S7, S4, S5, S6, BT, S3, T5.0H, S2, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigGF" /TUshortPSig="0.00699, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S750" upshifts 2119268 /Source="Nicolas_upshifts" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" upshifts complement(2119278) /Source="Nicolas_upshifts" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" promotor_-35 complement(2119295..2119301) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2119329..2119336 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2119349..2119368 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2119355 /Source="Nicolas_upshifts" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" CDS 2119393..2120751 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14766544, 15849754, 15855508, 16850406, 16954325, 17114254; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+-driven efflux MatE family protein" /protein_id="NP_389826.1" /db_xref="EnsemblGenomes-Gn:BSU19440" /db_xref="EnsemblGenomes-Tr:CAB13836" /db_xref="GOA:O31855" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13561" /db_xref="UniProtKB/Swiss-Prot:O31855" /translation="MKETQNAREKIKQLLHILIPIFITQAGLSLITFLDTVMSGKVSP ADLAGVAIGSSLWTPVYTGLAGILMAVTPIVAQLLGAEKKQKIPFTVLQAVYVAALLS IAVLVIGYAAVDLILGRLNLDIHVHQIAKHFLGFLSLGIFPLFVYTVLRSFIDSLGKT RVTMMITLSSLPINFVLNYVFIFGKFGMPALGGVGAGLASALTYWCICIISFFIIHKN APFSEYGIFLTMYKFSWKACKNLLKIGLPIGFAVFFETSIFAAVTLLMSHFHTVTIAS HQAAMNFASLLYMLPLSVSMALTIVVGFEAGAARFKDARSYSLIGIMMAIGFSLFTAA CILLFREQIAGMYTSDPDVLRLTQHFLIYALFFQLSDAVAAPIQGALRGYKDVNYTLA AAFVSYWVIGLPVGYMVGTFTSLGAFGYWIGLIAGLAAGAVGLFFRLAKLQKRYSQKQ HI*" gene 2119393..2120751 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" promotor_-10 complement(2119735..2119746) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2119740) /Source="Nicolas_upshifts" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2119760..2119766) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2120767..2121615 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665, 20935101, 22287516, 24599254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665, 20935101, 22287516, 24599254; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-antagonist of RsbT; component of the anxiosome (stressosome)" /protein_id="NP_389827.1" /db_xref="EnsemblGenomes-Gn:BSU19450" /db_xref="EnsemblGenomes-Tr:CAB13837" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG13560" /db_xref="UniProtKB/Swiss-Prot:O31856" /translation="MAKNKKLFEYLSQHAETISSTWYETIEETDPNSIYASTDPVVIH NLKSQNLAFNYKINRIFIDDEDVYLPILKEWAFEVTQDQEHLKTPIHYIIREFVRVRD LYVSYVKEFVHLNQNTVKSEEAEDLYHALIKAFDLVIHIFIEEMYKNTSLQLQAQKDM ITELSAPVIVLFHSVGLLPLIGDIDTVRAKLIMENTLHQCAKKKVTQLYIDLSGVAVI DTMVAHQLFSLIEALRLIGVSSTLSGIRPEIAQTAVQLGLSFEGISLRSTLASAIASD LKLKKV*" gene 2120767..2121615 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" promotor_-10 complement(2121031..2121050) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2121038) /Source="Nicolas_upshifts" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2121064..2121072) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2121578 /Source="Nicolas_upshifts" /id="D1071" /incds=0 /nref=10 /ntot=138 /MaxReadThrough="1.62054" /MaxDrop="3.13267" /score="12.3887642" /energy="-14" /TU="NA" /idTUdmin="U1591" /TUdmin=0 /isTUend="TRUE" downshifts complement(2121610) /Source="Nicolas_upshifts" /id="D1072" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="1.55562" /MaxDrop="4.60101" /score="23.8391861" /energy="-13.7" /TU="NA" /idTUdmin="U1594" /TUdmin=22 /isTUend="TRUE" CDS complement(2121641..2122306) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" /EC_number="3.5.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15136574, 20308541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15136574, 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate N-acetylglucosamine deacetylase (second enzyme)" /protein_id="YP_054582.2" /db_xref="EnsemblGenomes-Gn:BSU19460" /db_xref="EnsemblGenomes-Tr:CAB13838" /db_xref="GOA:O31857" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023841" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG13559" /db_xref="UniProtKB/Swiss-Prot:O31857" /translation="MKEHVLVILPHPDDESYGVAGLIALNRKKDIPVTYACATLGEMG RNMGDPFFANRETLPLLRKQELINACKEMDINDLRMLGLRDKTLEFEDDEYLADIMEE IIDDVKPSLIVTFYPGHGVHPDHDACGEAVIRALYRKKKEDRPRTICMAITRNREEVL GEADVVLDIKEVADIKMNALRAHRTQTEGMLRELEEKLKNNEPVMATWFEEEIYWTYQ WND*" gene complement(2121641..2122306) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" downshifts complement(2121655) /Source="Nicolas_upshifts" /id="D1073" /incds=0 /nref=189 /ntot=251 /MaxReadThrough="3.68743" /MaxDrop="7.13247" /score="23.8391861" /energy="-13.7" /TU="U1594" /idTUdmin="U1596" /TUdmin="-1" /isTUend="TRUE" CDS complement(2122325..2122675) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (bacillithiol synthesis operon)" /protein_id="NP_389829.1" /db_xref="EnsemblGenomes-Gn:BSU19470" /db_xref="EnsemblGenomes-Tr:CAB13839" /db_xref="InterPro:IPR014934" /db_xref="InterPro:IPR036492" /db_xref="PDB:1NJH" /db_xref="SubtiList:BG13558" /db_xref="UniProtKB/Swiss-Prot:O31858" /translation="MKAIIKEDVQASLERYADRPVYIHLETTTGSYSAHLNEKNMTVV AYIRNAKVTYHQAKIKGNGPYRVGLKTEEGWIYAEGLTEYTVDEENRLLMAGHLPGGK LAISLQISEKPFTV*" gene complement(2122325..2122675) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" CDS complement(2122672..2122950) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097741.1" /db_xref="EnsemblGenomes-Gn:BSU19479" /db_xref="EnsemblGenomes-Tr:CAX52638" /db_xref="UniProtKB/Swiss-Prot:O68260" /translation="MDNDKEIVKAYASLWNNRSLAHDDAEAVAEAIDLELLDKRTHPR LRKPMLEKYFAAIQRIVNSQLEPAVKYQLVKLHTERAEYLKEERGEQS*" gene complement(2122672..2122950) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" promotor_-10 complement(2122977..2122996) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2122993) /Source="Nicolas_upshifts" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" promotor_-35 complement(2123011..2123017) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2123026..2123922) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636, 23944997; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative N-acetylated toxic metabolites" /protein_id="NP_389830.2" /db_xref="EnsemblGenomes-Gn:BSU19480" /db_xref="EnsemblGenomes-Tr:CAB13840" /db_xref="GOA:O31859" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004626" /db_xref="SubtiList:BG13557" /db_xref="UniProtKB/Swiss-Prot:O31859" /translation="MQHAETKKGVIYTAVSFIMWGLFPLYWKLLEQLPALDILAHRII WSFVFMCIVLFFLRQWKIGWQELRSLKKNGGILSLFLASILISINWFVYIWAVNHGFL LEASLGYYINPLVSVLLGILFLKEKLNRLQLVAVSIAAAGVIISAFQYGSIPYVALLL AFSFGLYGLSKKRTSLPSAIGLTLETFMIMPIALGYLLFSGHVQPAGAESGGTWLLLF LAGVFTALPLLLFAEGAKRLPLYQVGILQYIAPTITLLIGLFVYHEPFSSSKAFTFSC IWAALLLFTFSQVKWKRASKSH*" gene complement(2123026..2123922) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" promotor_-35 2123764..2123773 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2123784 /Source="Nicolas_upshifts" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" promotor_-10 2123787..2123806 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2123802..2124020 /Source="Nicolas_S_feature" /locus_tag="new_2123802_2124020" /HighExp="S6, S8, S7, BT, S5, B36, G/S, Pyr, B60, SMMPr" /AntisenseName="yojE" /AntisenseCor="-0.562105310907978" /AntisenseRegPval="-23.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S751" promotor_-10 complement(2123946..2123965) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2123966) /Source="Nicolas_upshifts" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" promotor_-35 complement(2123977..2123984) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2124021..2124494 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17720779" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17720779; Product type s: structure" /codon_start=1 /transl_table=11 /product="component of the spore coat" /protein_id="YP_054583.1" /db_xref="EnsemblGenomes-Gn:BSU19490" /db_xref="EnsemblGenomes-Tr:CAE01457" /db_xref="GOA:Q7WY67" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG14190" /db_xref="UniProtKB/Swiss-Prot:Q7WY67" /translation="MFEWNKYFPFHNQFSKEALKKADPKEVETYVNRVMESVFGSDYA AQFPFRDPLPQKEHPAKPDAKPDVKPDIDIFETADHVFVKVPISEEWLEQVRIKHTSH ELWLENLPRADHPKKVNLPCLVKRKGTKAVYKDGLLEVMFQKQQDYNMSEVEIIR*" gene 2124021..2124494 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" downshifts 2124491 /Source="Nicolas_upshifts" /id="D1074" /incds=0 /nref=23 /ntot=53 /MaxReadThrough="-0.0703700000000005" /MaxDrop="9.27889" /score="40.8456275" /energy="-16.6" /TU="NA" /idTUdmin="U1595" /TUdmin=7 /isTUend="TRUE" CDS complement(2124529..2124765) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389832.1" /db_xref="EnsemblGenomes-Gn:BSU19510" /db_xref="EnsemblGenomes-Tr:CAB13842" /db_xref="GOA:O31861" /db_xref="SubtiList:BG13555" /db_xref="UniProtKB/Swiss-Prot:O31861" /translation="MYPHHSYLRGIPGPAGYPARSPFLFGAPLVGGLLGGFLGSALFN YSRPYAYPPGPYGYGGGPYGFGAGVPYGGYPGFY*" gene complement(2124529..2124765) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" downshifts complement(2124537) /Source="Nicolas_upshifts" /id="D1075" /incds=0 /nref=37 /ntot=68 /MaxReadThrough="2.10188" /MaxDrop="7.8003" /score="35.4403926" /energy="-16.6" /TU="NA" /idTUdmin="U1597" /TUdmin=1 /isTUend="TRUE" promotor_-10 complement(2124788..2124807) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2124803) /Source="Nicolas_upshifts" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" promotor_-35 complement(2124821..2124830) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2124850..2126184) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 3020045, 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/anion permease" /protein_id="NP_389833.1" /db_xref="EnsemblGenomes-Gn:BSU19520" /db_xref="EnsemblGenomes-Tr:CAB13843" /db_xref="GOA:O31862" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG13554" /db_xref="UniProtKB/Swiss-Prot:O31862" /translation="MPILIVAVGVLILLFLIIKVKLNTFVSLIVVSFLVAIGLGMDIN KIVLSIETGIGGQLGHLALVFGLGAMLGRLVSDAGGGYRIAITLIDKFGRKRIQAAVV VASFIIGIALFFEVGLVLLIPIVYAIAKELKMPFLYLGIPMAAALNVTHGFLPPHPAP TAISVAYGAHIGQVLLFGIIIAVPTTVIAGPLFNKFAMKRFPGAYQKHGNLSGLGPRK EFQLDETPGFAISAVTSLFPVIFMAMATIFSLLLSEHSKGKDIIEFIGTPGTAMLISL LLALYTMGYARKISMQEIGRSISESISQIAMMLLIIGGGGAFKQVLIDGGVGDYVADF FRQTNMSPLFVAWTIAAVLRLCLGSATVAALTTAGMAAPLMEAGSVNPALMVLATGAG SVIACHVNDAGFWMVKEFFGLSMKETFQTWTLLTTVLSVTGLGCVLLAGLVM*" gene complement(2124850..2126184) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" S_feature complement(2126185..2126320) /Source="Nicolas_S_feature" /locus_tag="new_2126185_2126320_c" /HighExp="M0t90, M40t90, Lbtran, S1, dia5, Mt0, T0.0H, BI, Lbstat, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25781100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S752" promotor_-10 complement(2126317..2126336) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2126327) /Source="Nicolas_upshifts" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" promotor_-35 complement(2126351..2126358) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2126416..2126423 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2126438..2126457 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2126441 /Source="Nicolas_upshifts" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" S_feature 2126442..2126548 /Source="Nicolas_S_feature" /locus_tag="new_2126442_2126548" /HighExp="M0t90, M40t90, LoTm, Salt, Cold, BI, HPh, LBGstat, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S753" CDS 2126549..2126938 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" /EC_number="5.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tautomerase" /protein_id="NP_389834.1" /db_xref="EnsemblGenomes-Gn:BSU19530" /db_xref="EnsemblGenomes-Tr:CAB13844" /db_xref="GOA:O34882" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG13530" /db_xref="UniProtKB/Swiss-Prot:O34882" /translation="MPLLRFDVIEGRDEKSLQLLLDTAHQAMVEAFGVPERDRYQIVH QHPANELIIQDAGLGFQRTKDMVIISMTSKARTESQKEKLYALLAERLEKKCEISPDD LMVSITENGDADWSFGLGEAQFLNGKL*" gene 2126549..2126938 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" downshifts 2126948 /Source="Nicolas_upshifts" /id="D1076" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="1.20831" /MaxDrop="2.65754" /score="14.4455719" /energy="-13.2" /TU="NA" /idTUdmin="U1599" /TUdmin=0 /isTUend="TRUE" CDS complement(2127345..2127683) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17158660, 18208493, 20652907, 27531959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17158660, 18208493, 20652907, 27531959; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_389835.1" /db_xref="EnsemblGenomes-Gn:BSU19540" /db_xref="EnsemblGenomes-Tr:CAB13845" /db_xref="GOA:O34844" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:5HS7" /db_xref="PDB:5HS8" /db_xref="PDB:5HS9" /db_xref="SubtiList:BG13531" /db_xref="UniProtKB/Swiss-Prot:O34844" /translation="MGNTMCPKMESAFSLLGKRWNGLIIHVLMDGPKRFKEITETIPM ISQKMLAERLKELEQNEIVERQVLPETPVKVIYTLTEKGTALQAVFQEMQAWADQFCE PGDTVCEEEK*" gene complement(2127345..2127683) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" promotor_-35 2127706..2127713 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2127727..2127746 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2127736 /Source="Nicolas_upshifts" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" S_feature 2127740..2127812 /Source="Nicolas_S_feature" /locus_tag="new_2127740_2127812" /HighExp="dia5, Diami, dia15, Salt, Lbtran, Heat, HiOs, S1, aero, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S754" promotor_-10 complement(2127771..2127790) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2127774) /Source="Nicolas_upshifts" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" promotor_-35 complement(2127802..2127808) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2127813..2128421 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" /EC_number="1.6.99.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 21749987, 24525333, 26312069; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="water forming NADH oxidase (nitroreductase)" /protein_id="NP_389836.1" /db_xref="EnsemblGenomes-Gn:BSU19550" /db_xref="EnsemblGenomes-Tr:CAB13846" /db_xref="GOA:P81102" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG13532" /db_xref="UniProtKB/Swiss-Prot:P81102" /translation="MTNTLDVLKARASVKEYDTNAPISKEELTELLDLATKAPSAWNL QHWHFTVFHSDESKAELLPVAYNQKQIVESSAVVAILGDLKANENGEEVYAELASQGY ITDEIKQTLLGQINGAYQSEQFARDSAFLNASLAAMQLMIAAKAKGYDTCAIGGFNKE QFQKQFDISERYVPVMLISIGKAVKPAHQSNRLPLSKVSTWL*" gene 2127813..2128421 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" downshifts 2128411 /Source="Nicolas_upshifts" /id="D1077" /incds=0 /nref=98 /ntot=245 /MaxReadThrough="1.58009" /MaxDrop="5.56809" /score="28.8840715" /energy="-14.3" /TU="NA" /idTUdmin="U1600" /TUdmin="-11" /isTUend="TRUE" CDS complement(2128464..2129066) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389837.1" /db_xref="EnsemblGenomes-Gn:BSU19560" /db_xref="EnsemblGenomes-Tr:CAB13847" /db_xref="GOA:O34842" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13533" /db_xref="UniProtKB/Swiss-Prot:O34842" /translation="MKHIYEKGTSDNVLLLLHGTGGNEHDLLSLGRFIDPDAHLLGVR GSVLENGMPRFFKRLSEGVFDEKDLVVRTRELKDFIDEAAETHQFNRGRVIAVGYSNG ANIAASLLFHYKDVLKGAILHHPMVPIRGIELPDMAGLPVFIGAGKYDPLCTKEESEE LYRYLRDSGASASVYWQDGGHQLTQHEAEQAREWYKEAIV*" gene complement(2128464..2129066) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" CDS complement(2129082..2129993) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 17407181, 19329649, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-dependent lyase/dioxygenase" /protein_id="NP_389838.1" /db_xref="EnsemblGenomes-Gn:BSU19570" /db_xref="EnsemblGenomes-Tr:CAB13848" /db_xref="GOA:O34543" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13534" /db_xref="UniProtKB/Swiss-Prot:O34543" /translation="MKTEGLHHVTAFARDPQENLRFYTEVLGLRLVKKTVNFDDPGTY HFYFGNQNGDPGTIMTFFPFQGSGQGTVGKGQAGRVYFSVPSGSLSFWKERLEKSGLS LEEKTLFGEKGLIFDDTEDLPLAIMEDAKSGKSEWTPDGITTNEAITGMKGVLLYSYD PQATIQLLTESFGYTKVAEEDQIVRLASSAAVGGVIDVHLHPEKRGVGGYGTVHHVAF RTKKKEQAKWLPIIAENHLPSSEILDREYFTSVYFREKGGILFEIATDEPGFMTDETF AELGTSLKLPEWLEKHRQQITDILPEL*" gene complement(2129082..2129993) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" promotor_-10 complement(2130022..2130041) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2130038) /Source="Nicolas_upshifts" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" promotor_-35 complement(2130057..2130062) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2130114..2130117 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2130132..2130151 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2130134 /Source="Nicolas_upshifts" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" CDS 2130177..2130377 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016, 24843172; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="YP_003097742.1" /db_xref="EnsemblGenomes-Gn:BSU19579" /db_xref="EnsemblGenomes-Tr:CAX52639" /db_xref="GOA:C0H431" /db_xref="InterPro:IPR021741" /db_xref="UniProtKB/Swiss-Prot:C0H431" /translation="MVKKALIVILILLPFVQLALLPLVNRIEPIMFGLPFFHFWLLLW IIVTPLCSFGIYQMQKKDGGLE*" gene 2130177..2130377 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" CDS 2130377..2131867 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12823818, 15849754, 16850406, 24142252, 27766092; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite permease" /protein_id="NP_389839.1" /db_xref="EnsemblGenomes-Gn:BSU19580" /db_xref="EnsemblGenomes-Tr:CAB13849" /db_xref="GOA:O34745" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13535" /db_xref="UniProtKB/Swiss-Prot:O34745" /translation="MQGNLTALLITAIIVLTVVCIGFLAGRDKSSRTSVEEWSVGGRR FGGLLVWFLVGADLYTAYTFLGLTSTAFTGGSVAFFAIPYSVLAYFIAYFFLPKLWKV AKIHKLTTLADYARERFNSKLLASLVAIVGVLMLIPYICLQLSGIQDTLQVAGTGYIN VKFVVIISFILVALYTFFSGIKGPTYTAIIKDILVWVIMLFMVVSLPLIHFNGWTPMI DTLVKEAPQMLTIPSEGPKGIPWFITASIVSALALFMWAHAATGVFTAKSADAVRKNS MFLPLYNIVLILVIFLGFIAFLVLPEDTNPRLALLHLIQTSYGGVAQGFAYATIALAS LIPCSIMAIGASNLFANNLYRDLIHPNVSQSKLTLVTRSMVFVVIGLALLFGMLFPTA LVTLQLLGVSGMVQIFPAIAVSLFWKNQTKEATVIGLLAGLAVTFIVYITQSAHGIYE GFWGLAANMIAVVILNPLFVKNAGSNPVIEGLFGKKQDANPNQKGA*" gene 2130377..2131867 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" promotor_-10 complement(2131112..2131123) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2131116) /Source="Nicolas_upshifts" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2131137..2131143) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2131855 /Source="Nicolas_upshifts" /id="D1078" /incds=0 /nref=128 /ntot=189 /MaxReadThrough="1.75716" /MaxDrop="6.37839" /score="42.3111155" /energy="-14.6" /TU="NA" /idTUdmin="U1603" /TUdmin="-21" /isTUend="TRUE" CDS complement(2131902..2133302) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" /EC_number="3.4.21.102" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8996100, 10974125, 14526016, 17114254, 19889088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxy-terminal processing protease (Prc homolog, tail specific protease)" /protein_id="NP_389840.1" /db_xref="EnsemblGenomes-Gn:BSU19590" /db_xref="EnsemblGenomes-Tr:CAB13850" /db_xref="GOA:O34666" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11794" /db_xref="UniProtKB/Swiss-Prot:O34666" /translation="MKRQLKLFFIVLITAVVASALTLFITGNSSILGQKSASTGDSKF DKLNKAYEQIKSDYYQKTDDDKLVDGAIKGMIQSLDDPYSTYMDQEQAKSFDETISAS FEGIGAQVEEKDGEILIVSPIKGSPAEKAGIKPRDQIIKVNGKSVKGMNVNEAVALIR GKKGTKVKLELNRAGVGNIDLSIKRDTIPVETVYSEMKDNNIGEIQITSFSETTAKEL TDAIDSLEKKGAKGYILDLRGNPGGLMEQAITMSNLFIDKGKNIMQVEYKNGSKEVMK AEKERKVTKPTVVLVNDGTASAAEIMAAALHESSNVPLIGETTFGKGTVQTAKEYDDG STVKLTVAKWLTADGEWIHKKGIKPQVKAELPDYAKLPYLDADKTYKSGDTGTNVKVA QKMLKALGYKVKVNSMYDQDFVSVVKQFQKKEKLNETGILTGDTTTKLMIELQKKLSD NDTQMEKAIETLKKEM*" gene complement(2131902..2133302) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" downshifts complement(2131926) /Source="Nicolas_upshifts" /id="D1079" /incds=0 /nref=188 /ntot=292 /MaxReadThrough="0.590400000000001" /MaxDrop="7.62713" /score="34.5981085" /energy="-14.6" /TU="NA" /idTUdmin="U1606" /TUdmin="-18" /isTUend="TRUE" promotor_-35 2133073..2133082 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2133094..2133109 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2133108 /Source="Nicolas_upshifts" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2133322..2133341) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2133342) /Source="Nicolas_upshifts" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" promotor_-35 complement(2133355..2133362) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2133401..2133410 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2133416 /Source="Nicolas_upshifts" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" promotor_-10 2133423..2133442 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2133455..2134156 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19703276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_389841.1" /db_xref="EnsemblGenomes-Gn:BSU19600" /db_xref="EnsemblGenomes-Tr:CAB13851" /db_xref="GOA:O34954" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13536" /db_xref="UniProtKB/Swiss-Prot:O34954" /translation="MSRYLEMLSLFGVAGAHPGGLAFSKAVLQKAAPSPDQPILDAGC GTGQTAAYLGHLLYPVTVVDKDPIMLEKAKKRFANEGLAIPAYQAELEHLPFSSESFS CVLSESVLSFSRLTSSLQEISRVLKPSGMLIGIEAALKKPMPPAEKKQMMDFYGFTCL HEESEWHKLLRSYGFQKTEAMSLLPEDMEFEPTTEMDLSQTIDPIYYDTLQTHYQLMQ LYSEYMGHCIFIAYK*" gene 2133455..2134156 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" promotor_-35 2134181..2134189 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2134203..2134222 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2134208 /Source="Nicolas_upshifts" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" CDS 2134244..2134495 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546, 23155385; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389842.1" /db_xref="EnsemblGenomes-Gn:BSU19610" /db_xref="EnsemblGenomes-Tr:CAB13852" /db_xref="GOA:O34654" /db_xref="SubtiList:BG13537" /db_xref="UniProtKB/Swiss-Prot:O34654" /translation="MERYYHLCKNHQGKVVRITERGGRVHVGRITRVTRDRVFIAPVG GGPRGFGYGYWGGYWGYGAAYGISLGLIAGVALAGLFFW*" gene 2134244..2134495 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" downshifts 2134516 /Source="Nicolas_upshifts" /id="D1080" /incds=0 /nref=49 /ntot=83 /MaxReadThrough="0.88268" /MaxDrop="7.18785" /score="13.9812819" /energy="-15.5" /TU="NA" /idTUdmin="U1607" /TUdmin=0 /isTUend="TRUE" CDS complement(2134566..2135387) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" /EC_number="3.4.16.4" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8631706, 15187182, 24909784" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8631706, 15187182, 24909784; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase lipoprotein (D-ala releasing from tetrapeptide hydrolysis)" /protein_id="NP_389843.1" /db_xref="EnsemblGenomes-Gn:BSU19620" /db_xref="EnsemblGenomes-Tr:CAB13853" /db_xref="GOA:O34866" /db_xref="InterPro:IPR003709" /db_xref="InterPro:IPR009045" /db_xref="PDB:4OX3" /db_xref="SubtiList:BG13538" /db_xref="UniProtKB/Swiss-Prot:O34866" /translation="MKKSGKWFSLAAALSVTAIVGAGCSMSNGDAQKDTKTTAETKQT EQKTADSKKSNTQNSEFSLESQYFNDIKKVDGLETIQNPENILALVNKQYALPGNYEP SDLVIPDVEFSFEEKIQKRYIRKEAADALKTMFDAAKKEGYELAAVSGYRSYDRQKVI FDNEVSLKGERKAKEAVAYPGESEHQTGLAMDISSRSNGFELNEAFGSTADGKWVQDN AYKYGFIIRYPKNKEDITKYEYEPWHLRYVGKKAAKVIQDNDLTLEEYFEKVKKI*" gene complement(2134566..2135387) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" downshifts complement(2134592) /Source="Nicolas_upshifts" /id="D1081" /incds=0 /nref=180 /ntot=242 /MaxReadThrough="0.784690000000001" /MaxDrop="5.88637" /score="-9.13236272" /energy="-6.1" /TU="NA" /idTUdmin="U1609" /TUdmin=0 /isTUend="TRUE" S_feature complement(2135388..2135469) /Source="Nicolas_S_feature" /locus_tag="new_2135388_2135469_c" /HighExp="dia15, LBGexp, G180, LBGtran, dia0, H2O2, Oxctl, Lbexp, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S755" CDS complement(2135470..2136171) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12571059, 16511068, 21279421, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12571059, 16511068, 21279421, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_389844.1" /db_xref="EnsemblGenomes-Gn:BSU19630" /db_xref="EnsemblGenomes-Tr:CAB13854" /db_xref="GOA:O34925" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR004402" /db_xref="InterPro:IPR018016" /db_xref="InterPro:IPR035994" /db_xref="PDB:4D8V" /db_xref="PDB:4D8X" /db_xref="PDB:4D8Y" /db_xref="PDB:4D98" /db_xref="PDB:4D9H" /db_xref="PDB:4DA0" /db_xref="PDB:4DA6" /db_xref="PDB:4DA7" /db_xref="PDB:4DA8" /db_xref="PDB:4DAB" /db_xref="PDB:4DAE" /db_xref="PDB:4DAN" /db_xref="PDB:4DAO" /db_xref="PDB:4DAR" /db_xref="SubtiList:BG12581" /db_xref="UniProtKB/Swiss-Prot:O34925" /translation="MSVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRG MYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRD VILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFY NDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQT TFHDMIEVALHSVSQ*" gene complement(2135470..2136171) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" S_feature complement(2136172..2136261) /Source="Nicolas_S_feature" /locus_tag="new_2136172_2136261_c" /HighExp="dia15, G180, dia5, LBGtran, dia0, LBGexp, Lbexp, G150, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S756" promotor_-10 complement(2136246..2136265) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2136261) /Source="Nicolas_upshifts" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" promotor_-35 complement(2136281..2136285) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2136319..2136325 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2136340..2136351 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2136357 /Source="Nicolas_upshifts" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" CDS 2136373..2136498 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24079885" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097743.1" /db_xref="EnsemblGenomes-Gn:BSU19639" /db_xref="EnsemblGenomes-Tr:CAX52640" /db_xref="UniProtKB/Swiss-Prot:C0H432" /translation="MGKKHRNRITGQKKNNHIPEKDIIAAEEAHGKEYSAAKRKP*" gene 2136373..2136498 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" downshifts 2136496 /Source="Nicolas_upshifts" /id="D1082" /incds=0 /nref=9 /ntot=26 /MaxReadThrough="0.67198" /MaxDrop="4.89617" /score="16.4028635" /energy="-8.5" /TU="NA" /idTUdmin="U1610" /TUdmin=0 /isTUend="TRUE" CDS complement(2136538..2136852) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24079885, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24079885, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="shape determination factor" /protein_id="NP_389845.2" /db_xref="EnsemblGenomes-Gn:BSU19640" /db_xref="EnsemblGenomes-Tr:CAB13855" /db_xref="InterPro:IPR025923" /db_xref="SubtiList:BG13539" /db_xref="UniProtKB/Swiss-Prot:O30472" /translation="MMLSVFKKKSCSYDVTIFQTPRFGEKKGYRAVYRTELNGSDHQD VLKRAFSLFNVFDTVPSDYDARFMATGDVILIDEGRKGKTYYQLLPAGWRKINRLIVQ TT*" gene complement(2136538..2136852) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" downshifts complement(2136550) /Source="Nicolas_upshifts" /id="D1083" /incds=0 /nref=96 /ntot=232 /MaxReadThrough="1.74792" /MaxDrop="5.79235" /score="-0.334745097" /energy="-8.5" /TU="NA" /idTUdmin="U1611" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2136873..2136891) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2136880) /Source="Nicolas_upshifts" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" promotor_-35 complement(2136902..2136910) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2136913..2137524) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" /EC_number="3.1.3.27" /EC_number="3.1.3.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27528508, 28168443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27528508, 28168443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol phosphate (PGP) phosphatase; undecaprenyl-pyrophosphate phosphatase (promiscuous activity)" /protein_id="NP_389846.1" /db_xref="EnsemblGenomes-Gn:BSU19650" /db_xref="EnsemblGenomes-Tr:CAB13856" /db_xref="GOA:O34349" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR036938" /db_xref="PDB:5JKI" /db_xref="SubtiList:BG13540" /db_xref="UniProtKB/Swiss-Prot:O34349" /translation="MYKPVSLFLFFLILAAAIHTNAVQSADEAISKAAVLIRQPWLNE VMTGITHLGASSFLLPLIVIIGAGMFFYRKTWDGLLMLLVFGTDRLLNKVLKEWIERV RPDFAPLVHESSFSFPSGHSMNAACVYPVIAYFLVKHLPFLSKHKKMVYIIAGVIAVL VGISRVYLGVHFVTDVLGGFSLGLLLFFLVKGFDEKIKRFRQK*" gene complement(2136913..2137524) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" CDS complement(2137602..2137778) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389847.1" /db_xref="EnsemblGenomes-Gn:BSU19660" /db_xref="EnsemblGenomes-Tr:CAB13857" /db_xref="InterPro:IPR025545" /db_xref="SubtiList:BG13751" /db_xref="UniProtKB/Swiss-Prot:O31863" /translation="MKEIDLVIDTEEIAEFFYRELARRGYIPSEDELFEIADITFDYL IEKCMIDEELDEDE*" gene complement(2137602..2137778) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" downshifts complement(2137606) /Source="Nicolas_upshifts" /id="D1084" /incds=0 /nref=35 /ntot=48 /MaxReadThrough="3.33111" /MaxDrop="5.99901" /score="19.8458751" /energy="-11.9" /TU="U1612,U1613" /idTUdmin="U1615" /TUdmin=0 /isTUend="TRUE" upshifts complement(2137617) /Source="Nicolas_upshifts" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" promotor_-10 complement(2137621..2137640) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2137656..2137659) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2137792..2137810) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-10" upshifts complement(2137813) /Source="Nicolas_upshifts" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" S_feature complement(2137815..2138036) /Source="Nicolas_S_feature" /locus_tag="new_2137815_2138036_c" /HighExp="S8, S7, S6, BT, B36, Pyr, G/S, H2O2, S5, G135" /AntisenseName="yoyF" /AntisenseCor="0.43167183745996701" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S757" promotor_-35 complement(2137826..2137831) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-35" promotor_-35 2137836..2137841 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2137856..2137874 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2137858 /Source="Nicolas_upshifts" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" CDS 2137897..2138040 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097744.1" /db_xref="EnsemblGenomes-Gn:BSU19669" /db_xref="EnsemblGenomes-Tr:CAX52641" /db_xref="GOA:C0H433" /db_xref="UniProtKB/Swiss-Prot:C0H433" /translation="MIAKMMEALDGERFDIIMEKTLKGMTRVMIWGCLPYFLYVLIRM FTN*" gene 2137897..2138040 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" CDS complement(2138037..2138717) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389848.1" /db_xref="EnsemblGenomes-Gn:BSU19670" /db_xref="EnsemblGenomes-Tr:CAB13858" /db_xref="SubtiList:BG13541" /db_xref="UniProtKB/Swiss-Prot:O34414" /translation="MKQNKPKFQVGDIVVVIMYGTVGTITKVHQIDKHYLYEVNHNEV LYFESSIQLYKDYEGVIVDMEKLDIEYEFLIGDVVYVKDYGKELFRIIGHRTEIWRYL EDGWEDIIYELTRLKDGEWLETEEEDLTLVLRKYEMDQFVHQLLFVHYVGETGHEIGE DIASSALLQFEGGDEDQDTLHILAVSIVDELLDIYNDYKILYEMFQDEEYKDMMMFVL ESLKEHFS*" gene complement(2138037..2138717) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" S_feature 2138041..2139052 /Source="Nicolas_S_feature" /locus_tag="new_2138041_2139052" /HighExp="LoTm, S3, S8, S7, S4, T5.0H, BT, T4.0H, Pyr, S6" /AntisenseName="yodN" /AntisenseCor="0.52628108909126403" /AntisenseRegPval="-19.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S758" promotor_-10 complement(2138744..2138763) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2138750) /Source="Nicolas_upshifts" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" promotor_-35 complement(2138777..2138786) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2138868..2139092) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389849.1" /db_xref="EnsemblGenomes-Gn:BSU19680" /db_xref="EnsemblGenomes-Tr:CAB13859" /db_xref="InterPro:IPR010673" /db_xref="InterPro:IPR023089" /db_xref="InterPro:IPR036806" /db_xref="PDB:2FJ6" /db_xref="SubtiList:BG13752" /db_xref="UniProtKB/Swiss-Prot:O31864" /translation="MKSFYHYLLKYRHPKPKDSISEFANQAYEDHSFPKTSTDYHEIS SYLELNADYLHTMATFDEAWDQYESEVHGR*" gene complement(2138868..2139092) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" downshifts complement(2138882) /Source="Nicolas_upshifts" /id="D1085" /incds=0 /nref=115 /ntot=243 /MaxReadThrough="1.81033" /MaxDrop="7.07662" /score="34.0666929" /energy="-10.8" /TU="NA" /idTUdmin="U1616" /TUdmin=0 /isTUend="TRUE" misc_feature complement(2139133..2139152) /Source="Nicolas_upshift_promotors" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2139145) /Source="Nicolas_upshifts" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" CDS complement(2139179..2139457) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344, 24914178" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097745.1" /db_xref="EnsemblGenomes-Gn:BSU19689" /db_xref="EnsemblGenomes-Tr:CAX52642" /db_xref="InterPro:IPR022451" /db_xref="InterPro:IPR022453" /db_xref="UniProtKB/Swiss-Prot:C0H434" /translation="MKTCEWCGELEAVPGRNTVYWELPDGTRAIELTDTPAMVCSSCG MTYQEENTVKEIEDQLLLIQTKKLPESLTYQQLMETERILKRNYFDFS*" gene complement(2139179..2139457) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" CDS complement(2139454..2140869) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" /EC_number="5.4.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10629195, 10839984, 11148055, 17254853, 18307109, 21538109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629195, 10839984, 11148055, 17254853, 18307109, 21538109; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="lysine 2,3-aminomutase" /protein_id="NP_389850.1" /db_xref="EnsemblGenomes-Gn:BSU19690" /db_xref="EnsemblGenomes-Tr:CAB13860" /db_xref="GOA:O34676" /db_xref="InterPro:IPR003739" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022459" /db_xref="InterPro:IPR025895" /db_xref="SubtiList:BG13542" /db_xref="UniProtKB/Swiss-Prot:O34676" /translation="MKNKWYKPKRHWKEIELWKDVPEEKWNDWLWQLTHTVRTLDDLK KVINLTEDEEEGVRISTKTIPLNITPYYASLMDPDNPRCPVRMQSVPLSEEMHKTKYD LEDPLHEDEDSPVPGLTHRYPDRVLFLVTNQCSMYCRYCTRRRFSGQIGMGVPKKQLD AAIAYIRETPEIRDCLISGGDGLLINDQILEYILKELRSIPHLEVIRIGTRAPVVFPQ RITDHLCEILKKYHPVWLNTHFNTSIEMTEESVEACEKLVNAGVPVGNQAVVLAGIND SVPIMKKLMHDLVKIRVRPYYIYQCDLSEGIGHFRAPVSKGLEIIEGLRGHTSGYAVP TFVVDAPGGGGKIALQPNYVLSQSPDKVILRNFEGVITSYPEPENYIPNQADAYFESV FPETADKKEPIGLSAIFADKEVSFTPENVDRIKRREAYIANPEHETLKDRREKRDQLK EKKFLAQQKKQKETECGGDSS*" gene complement(2139454..2140869) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" promotor_-35 2140125..2140128 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2140144..2140163 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2140149 /Source="Nicolas_upshifts" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2140898..2141725) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21538109, 24914178" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epsilon-amino-beta-lysine acetyl transferase" /protein_id="NP_389851.1" /db_xref="EnsemblGenomes-Gn:BSU19700" /db_xref="EnsemblGenomes-Tr:CAB13861" /db_xref="GOA:O34895" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022525" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13543" /db_xref="UniProtKB/Swiss-Prot:O34895" /translation="MLKSIKSSGVTAVLDHDGFNKRIRVVRYDGAIEKALPDIVAAAK EENAEKIIVYAKQHDEPILAKQLFAPEGYLKGYYLGHSACVMVRYLSESRRQTDSYTE EQEIIEAIYRTAPRLRNDSTPVFTMRKAETNDMYQLSMLYKKVFRTYPTPVFDPAYIE KTMNANTVYYIMLDHDRLISAASAEINPELGHAEITDCAVLPEYRGHSLTSFLIEALE KEMAGEDIVHVFSLARASSFGMNAVLYHSGYQYGGRLINNCFIAEGLENMNIWCKQL* " gene complement(2140898..2141725) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" CDS complement(2141703..2143013) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" /EC_number="3.5.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative deacetylase" /protein_id="NP_389852.1" /db_xref="EnsemblGenomes-Gn:BSU19710" /db_xref="EnsemblGenomes-Tr:CAB13862" /db_xref="GOA:O34984" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR033687" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12569" /db_xref="UniProtKB/Swiss-Prot:O34984" /translation="MRMQDIERKVIEWLDQHSAKAIRLLKRLIGEKSTLGSEFNAQAV VLEKLRQFHMDIDVWEPSIKQLKQHPYFKSNRSDFHESPNIVAKKTGAGGGRSLILNG HIDVVPEGSVKDWKYEPYQAVEENGKIYGRGSTDMKGGNTALLFALEALHACDVKLKG DVLFQSVVDEECGGAGTLSAIMRGYRADGALIPEPTNMKLFIKQQGSMWFRITVKGLS AHGGTRYEGVSAIEKSMHVITAIQELEKVRNARISDPLYDNIPIPVPVNIGTISGGAW PSSVADRVVIEGRCGIAPHEKPEAVKLELENWLKDLEYHDEWFKRHPVQVEWFGAQWL PNDLPDDHPLISVLQSAYQKMKQTEPIIEASPWGTDGGLLYHAGDTPVIVFGPGETKT AHQANEYIEVEAMIESAKIIALFVMDWCGLHTDGEDADAQVNKE*" gene complement(2141703..2143013) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" CDS complement(2143022..2143675) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyloate-acetoacetate CoA-transferase" /protein_id="NP_389853.1" /db_xref="EnsemblGenomes-Gn:BSU19720" /db_xref="EnsemblGenomes-Tr:CAB13863" /db_xref="GOA:O34466" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="SubtiList:BG13544" /db_xref="UniProtKB/Swiss-Prot:O34466" /translation="MGLGVAEREQIAKRAATEIKQGMIVNLGIGIPSLVPNFLKPDMQ VMFQAENGVLGIGESPEKGEEDAHLCNAAGYPVRAVKGASYFDTTMSFAMIRKGKIDI TILGALQVSQSGDLANWLVPGKKVPGMGGAMELAQKAKKVVVVMSHTDQKGRPKLTER CTLPLTAAGCVDLIITEKAVLEVDSHHFILKELMNGSTIDEVTRLTEAEIKIDMPFS* " gene complement(2143022..2143675) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" CDS complement(2143660..2144349) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxoacid CoA-transferase" /protein_id="NP_389854.1" /db_xref="EnsemblGenomes-Gn:BSU19730" /db_xref="EnsemblGenomes-Tr:CAB13864" /db_xref="GOA:O34317" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="SubtiList:BG13545" /db_xref="UniProtKB/Swiss-Prot:O34317" /translation="MAPFQKAISIDTAIADVRDGSVLMFGGFGGVGSPPSLIEAILDS GVTDLTVICNDAGFPDIGIGPLIVNQRVKTLIASHIGSNPVAGKQMTEGTLEVQFSPQ GTLAERIRAGGAGLGGILTDVGIDNQMVCEKKDIVTVAGKRYLIEEALTADFAFINAY IADEFGNLTYDKTARNMNPLMAMAARRTFAEAERIVPMGEISEEMIVTPGVFVEGVVR SEGVKWKWAWE*" gene complement(2143660..2144349) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" CDS complement(2144356..2145690) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" /EC_number="2.6.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10839984, 15150230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminovalerate aminotransferase" /protein_id="NP_389855.1" /db_xref="EnsemblGenomes-Gn:BSU19740" /db_xref="EnsemblGenomes-Tr:CAB13865" /db_xref="GOA:O34662" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13546" /db_xref="UniProtKB/Swiss-Prot:O34662" /translation="MSSYLIKPELSSAYPVVSYAKGSYVYDQTGKKYLDGSSGAVTCN IGHGVRDVTEKLKEQLDQVSFAYRSQFTSEPAEQLAALLAQELPGDVNWSFFVNSGSE AIETAMKIAIQYWQEKKQTQKSIFLSRWSSYHGITLGALSLSGFYERRYRFTHLIERY PAISAPHIYRLNHETEEDFVQTAADELDTMIKRIGSQFIAGFVAEPIIGAAGAAITPP PGYYERLSEVCRTHDVLFIADEVMTGLGRTGRMLATEHWDTVPDIAVLGKGLGAGYAP IAAAVVSDSIIETIKQGSGVIMSGHTYSAHPYSAKAALEVLRYVLKHGLIKQSEKKGA VLKKKLDEAASQSGIIGEVRGKGLLLGIEFVADQKTKKVFPPEQAITQLIVSEAKKRG LIVYPSKAGIDSGEGDAVIIAPPFTISDGEMEELISIFSETVAAVEKNLKKD*" gene complement(2144356..2145690) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" CDS complement(2145671..2145826) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513966.1" /translation="MLDAEISKEPSLLGRLFLCEKVFAGNVMPPFGHSYNMVKGVLRW EHEQLFD*" gene complement(2145671..2145826) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" promotor_-10 complement(2145709..2145727) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2145725) /Source="Nicolas_upshifts" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" promotor_-35 complement(2145743..2145748) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2145820..2146053) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a type I toxin family (sporulation operon)" /protein_id="YP_003097746.2" /db_xref="EnsemblGenomes-Gn:BSU19749" /db_xref="EnsemblGenomes-Tr:CAX52643" /db_xref="GOA:C0H435" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H435" /translation="MSGCILYFIISLHEIGVCTNHLGLGPHKMSYIVIRKDENSMYGY SGYGYGFGCGTNTFVLIVVLFILLIIVGAAFIC*" gene complement(2145820..2146053) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" downshifts complement(2145827) /Source="Nicolas_upshifts" /id="D1086" /incds=0 /nref=96 /ntot=237 /MaxReadThrough="2.70127" /MaxDrop="7.98506" /score="25.3834194" /energy="-16.5" /TU="NA" /idTUdmin="U1620" /TUdmin="-14" /isTUend="TRUE" promotor_-35 2145929..2145933 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2145942..2145956 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2145957 /Source="Nicolas_upshifts" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2145958..2145977) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2145967) /Source="Nicolas_upshifts" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" promotor_-35 complement(2145992..2146001) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2146013..2146792) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 7592393, 10066829, 27260256" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 7592393, 10066829, 27260256; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389856.1" /db_xref="EnsemblGenomes-Gn:BSU19750" /db_xref="EnsemblGenomes-Tr:CAB13866" /db_xref="GOA:P42093" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11197" /db_xref="UniProtKB/Swiss-Prot:P42093" /translation="MTGHYSKTEHQYILLTSESASFDHYSVYRDPQLPQIFSHNFVQL HDTFPLERLLNFLPSVPKLLDANYLHLKASPQHVFPLGLKQSLVKSGFVVEDELLYDM KLSDWKGQMGHPLTAWGTAKSLSDGSSIMKIYDSIYIGEAIAEQKLKRKYPFYEADII ILVVCYSDQAQKVPIGCGELFIDHQEKTAKIEEVAILDQFQRKGYGSILVKEMLSIAK SLGMEAAYLVAASTDGATQFYEKLTFKKYERVHTVFHYFLT*" gene complement(2146013..2146792) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" CDS complement(2146821..2148101) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in maturation of the outermost layer of the spore" /protein_id="NP_389857.1" /db_xref="EnsemblGenomes-Gn:BSU19760" /db_xref="EnsemblGenomes-Tr:CAB13867" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11196" /db_xref="UniProtKB/Swiss-Prot:P42092" /translation="MGEKVSIILTSYNKPDYLQKAIESVIQQTHDLWELFIMDDHSNA ETTAVIHKYLHDRRIQYHNSFVHPADRLKTARYATLINSALPFADGDYISYLTDDTVY HPERLSRMVQEFSHKPEAQAVYSKQKVVHVNERGEEISHFYRNANAVLDQAAFQVDHC SVMHRRSLLNLIHHKFGGYWDDDMKHWNHGDAIFWARLNNFTPFLPINEVLDTTYKTP DSFQNAYRFLPADLIDGSFVKGSDQNVYFFDQGVRHPVGEKWGFLYLNRTVAVPDPYL FQYRIGKILNIPNYILVKEADHPAIFYIEAGKKRRIVDQYAFQFYQFQRKDIVTIGKE EMETLPEGPPITWKRSELIKNPPGRRLFFIEREPFLFLNGVFHPISEQVTRKFFLHQK PISASFRNIQQFPIGKPFYPVYDEIIKKLNIATE*" gene complement(2146821..2148101) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" promotor_-10 complement(2147469..2147487) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2147485) /Source="Nicolas_upshifts" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" promotor_-35 complement(2147501..2147508) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2148069..2148087) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2148079) /Source="Nicolas_upshifts" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" promotor_-35 complement(2148103..2148108) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2148166..2148471) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389858.1" /db_xref="EnsemblGenomes-Gn:BSU19770" /db_xref="EnsemblGenomes-Tr:CAB13868" /db_xref="SubtiList:BG11195" /db_xref="UniProtKB/Swiss-Prot:P42091" /translation="MDLEKQVDREENQDDLHFILLLLILLIRQSSSEGNPSDLRRQLV FAKELGVPVSKVNLINGDTLQNVIVKEVLTDLVIFQNPLNNTRSHVSLSSVVSWGAF* " gene complement(2148166..2148471) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" downshifts complement(2148299) /Source="Nicolas_upshifts" /id="D1087" /incds=1 /nref=2 /ntot=28 /MaxReadThrough="5.32389" /MaxDrop="2.61092" /score="23.1569137" /energy="-13.4" /TU="U1623" /idTUdmin="U1623" /TUdmin="-2310" /isTUend="FALSE" promotor_-10 complement(2148495..2148514) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-10" upshifts complement(2148510) /Source="Nicolas_upshifts" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" promotor_-35 complement(2148528..2148537) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-35" promotor_-35 2148607..2148616 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2148630..2148649 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2148630 /Source="Nicolas_upshifts" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" upshifts complement(2148651) /Source="Nicolas_upshifts" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2148653..2148667) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2148676..2148680) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2148676..2149077 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:759239, 14702409, 15621419, 19933362, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 759239, 14702409, 15621419, 19933362, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore outermost layer component" /protein_id="NP_389859.1" /db_xref="EnsemblGenomes-Gn:BSU19780" /db_xref="EnsemblGenomes-Tr:CAB13869" /db_xref="SubtiList:BG11193" /db_xref="UniProtKB/Swiss-Prot:P42089" /translation="MSSENAQLKKDLIKAVLSPLFPTATEGGENMDSNLKALLDAAID QKVDESETVTAESILDPSLPARWIFARITPGTTISIVTDSGDMIGPVVFVAFDQVHGI VFVTQESSVTPAGQATTLIDVDKVESVTFFS*" gene 2148676..2149077 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" CDS 2149084..2150037 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389860.2" /db_xref="EnsemblGenomes-Gn:BSU19790" /db_xref="EnsemblGenomes-Tr:CAB13870" /db_xref="InterPro:IPR024542" /db_xref="SubtiList:BG11194" /db_xref="UniProtKB/Swiss-Prot:P42090" /translation="MKVLYIQSGYGGIYSYFDRWAEECFQNTHTEYMIADKPEAESLM KIEAFQPDFTLMMVGDRVPHDWLTWLKGKDIPVYVWLTEDPFYMDISLQVIKLADAIL TIEQNAALYYQELGYQNVYYVPIPVNHRLFKKMGTEHSYHSNLLIIGYPYPNRVQLMK EAVHLPFTVRVIGKEWGKYLPKKVLKQPHIDVVSTWVPPEQAVHYYNGADIVINAHRP YHFAFNQNTMRIKNASFNNRTFDIAACEAFQLTDLPAAHPFSSIISYHGMNDFKEKAA FYINHPEERQKAAAANYKETVPAFTFDELPAKLKAIHLALS*" gene 2149084..2150037 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" downshifts 2150027 /Source="Nicolas_upshifts" /id="D1088" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="2.94229" /MaxDrop="5.87549" /score="22.1420541" /energy="-9" /TU="NA" /idTUdmin="U1624" /TUdmin=0 /isTUend="TRUE" CDS complement(2150108..2151256) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" /EC_number="3.1.3.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phytase" /protein_id="NP_389861.1" /db_xref="EnsemblGenomes-Gn:BSU19800" /db_xref="EnsemblGenomes-Tr:CAB13871" /db_xref="GOA:P42094" /db_xref="InterPro:IPR003431" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11198" /db_xref="UniProtKB/Swiss-Prot:P42094" /translation="MKVPKTMLLSTAAGLLLSLTATSVSAHYVNEEHHFKVTAHTETD PVASGDDAADDPAIWVHEKHPEKSKLITTNKKSGLVVYDLDGKQLHSYEFGKLNNVDL RYDFPLNGEKIDIAAASNRSEGKNTIEVYAIDGDKGKLKSITDPNHPISTNISEVYGF SLYHSQKTGAFYALVTGKQGEFEQYEIVDGGKGYVTGKKVREFKLNSQTEGLVADDEY GNLYIAEEDEAIWKFNAEPGGGSKGQVVDRATGDHLTADIEGLTIYYAPNGKGYLMAS SQGNNSYAMYERQGKNRYVANFEITDGEKIDGTSDTDGIDVLGFGLGPKYPYGIFVAQ DGENIDNGQAVNQNFKIVSWEQIAQHLGEMPDLHKQVNPRKLKDRSDG*" gene complement(2150108..2151256) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" downshifts complement(2150125) /Source="Nicolas_upshifts" /id="D1089" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="2.64059" /MaxDrop="5.59857" /score="17.7154517" /energy="-8.7" /TU="NA" /idTUdmin="U1629" /TUdmin=2024 /isTUend="FALSE" promotor_-35 2151269..2151273 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2151282..2151301) /Source="Nicolas_upshift_promotors" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 2151289..2151308 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2151291) /Source="Nicolas_upshifts" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts 2151299 /Source="Nicolas_upshifts" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 2151560..2151568 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2151582..2151601 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2151585 /Source="Nicolas_upshifts" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" CDS 2151626..2152651 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014664318.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="polysaccharide biosynthesis protein" /protein_id="WP_003230816.1" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /translation="MPKQQTAELKPFFHNKTVLVTGGTGSIGSQIVKRLLMLTPKQVI VFSKDDSKQYVMSQKYAEDKRLLFVLGDVRDHRRVNQVMKGVDIVFHAAALKQVPTCE DHPFEAIQTNLIGGQNVVEAALSHRVQHVINISTDKAVSPVNTMGATKLLSEKLFHQA NRHVQNKGTLFCSVRFGNVLGSRGSVIPILFEQMMEGEPLTITDKNMTRFFMSIDDAA TLTLQSAAITKGGETFIFKMESLKLEELIHGFEEYASQHGLPRPAAVEVGKRPGEKLH EELTSPHEIESLYEWGNLYAILPEPEKHPDFRKVNLPGYQSDQAPLITKERIAQIIEE LHQEKKA*" /label="Delta6_BSU_19810-BSU_21670" gene 2151626..2152651 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /label="Delta6_BSU_19810-BSU_21670" downshifts 2152029 /Source="Nicolas_upshifts" /id="D1090" /incds=0 /nref=18 /ntot=39 /MaxReadThrough="0.75679" /MaxDrop="7.79081" /score="-6.65536786" /energy="-8.7" /TU="NA" /idTUdmin="U1628" /TUdmin=0 /isTUend="TRUE" SCAR 2152045..2152046 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="Delta_SP_beta" downshifts 2152643 /Source="Nicolas_upshifts" /id="D1134" /incds=0 /nref=22 /ntot=177 /MaxReadThrough="2.90949" /MaxDrop="5.54327" /score="-2.31796312" /energy="-13.5" /TU="NA" /idTUdmin="U1701" /TUdmin=0 /isTUend="TRUE" CDS complement(2152695..2153126) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" /EC_number="1.8.4.12" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15680230, 16803968, 17031545, 18239417, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine R-sulfoxide reductase" /protein_id="NP_390051.1" /db_xref="EnsemblGenomes-Gn:BSU21680" /db_xref="EnsemblGenomes-Tr:CAB14086" /db_xref="GOA:P54155" /db_xref="InterPro:IPR002579" /db_xref="InterPro:IPR011057" /db_xref="InterPro:IPR028427" /db_xref="PDB:2KZN" /db_xref="PDB:3E0O" /db_xref="SubtiList:BG11628" /db_xref="UniProtKB/Swiss-Prot:P54155" /translation="MAYNKEEKIKSLNRMQYEVTQNNGTEPPFQNEYWDHKEEGLYVD IVSGKPLFTSKDKFDSQCGWPSFTKPIEEEVEEKLDTSHGMIRTEVRSRTADSHLGHV FNDGPGPNGLRYCINSAALRFVPKHKLKEEGYESYLHLFNK*" gene complement(2152695..2153126) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" downshifts complement(2152700) /Source="Nicolas_upshifts" /id="D1135" /incds=0 /nref=229 /ntot=262 /MaxReadThrough="2.46559" /MaxDrop="6.77483" /score="1.42817565" /energy="-12.3" /TU="NA" /idTUdmin="U1704" /TUdmin="-3" /isTUend="TRUE" CDS complement(2153127..2153660) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" /EC_number="1.8.4.11" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9573155, 16803968, 17062561, 18662407" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573155, 16803968, 17062561, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine S-sulfoxide reductase" /protein_id="NP_390052.1" /db_xref="EnsemblGenomes-Gn:BSU21690" /db_xref="EnsemblGenomes-Tr:CAB14087" /db_xref="GOA:P54154" /db_xref="InterPro:IPR002569" /db_xref="InterPro:IPR036509" /db_xref="SubtiList:BG11627" /db_xref="UniProtKB/Swiss-Prot:P54154" /translation="MSEKKEIATFAGGCFWCMVKPFDEQPGIEKVVSGYTGGHTENPT YEEVCSETTGHREAVQITFHPDVFPYEKLLELFWQQIDPTDAGGQFADRGSSYRAAIF YHNDKQKELAEASKQRLAESGIFKDPIVTDILKAEPFYEAEGYHQHFYKKNPAHYQRY RTGSGRAGFISEHWGAK*" gene complement(2153127..2153660) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" promotor_-35 2153664..2153670 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2153681..2153791 /Source="Nicolas_S_feature" /locus_tag="new_2288083_2288193" /HighExp="B60, Lbstat, Cold, M9-stat, T4.0H, LoTm, S0, T3.30H, BC, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S817" upshifts 2153681 /Source="Nicolas_upshifts" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" promotor_-10 2153683..2153702 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2153688..2153707) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2153708) /Source="Nicolas_upshifts" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" promotor_-35 complement(2153723..2153724) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2153792..2154217 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9571784, 10809700; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_390053.1" /db_xref="EnsemblGenomes-Gn:BSU21700" /db_xref="EnsemblGenomes-Tr:CAB14088" /db_xref="GOA:P54182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11626" /db_xref="UniProtKB/Swiss-Prot:P54182" /translation="MKVRTQMMYDMETLLRKVFKQIRNEINEILDKELSRNEFTILRI LSEQGPKKVTEFAPILEVSASHITAVTDALVEKEWITRIRSKEDRRIIRIHITEAGEK VLQHFNEKKTEYFFKRFDCYTDAELATLIELFSKLDKKR*" gene 2153792..2154217 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" downshifts 2154205 /Source="Nicolas_upshifts" /id="D1136" /incds=0 /nref=92 /ntot=248 /MaxReadThrough="4.04021" /MaxDrop="5.35086" /score="-1.90494373" /energy="-7" /TU="U1703" /idTUdmin="U1703" /TUdmin="-1254" /isTUend="FALSE" S_feature 2154250..2155481 /Source="Nicolas_S_feature" /locus_tag="new_2288652_2289883" /HighExp="Cold, ferm, nit, C30, S0, Lbstat, T3.30H, T-4.40H, T5.0H, G135" /AntisenseName="dinF" /AntisenseCor="0.270994122332881" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S818" CDS complement(2154267..2155604) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11583854, 15849754, 16850406, 22933559, 26246409; Product type t : transporter" /codon_start=1 /transl_table=11 /product="damage inducible, Na+ driven multidrug efflux pump" /protein_id="NP_390054.1" /db_xref="EnsemblGenomes-Gn:BSU21710" /db_xref="EnsemblGenomes-Tr:CAB14089" /db_xref="GOA:P54181" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG11625" /db_xref="UniProtKB/Swiss-Prot:P54181" /translation="MKAYDFTQGNVLKQLVLFSMPIMLGNALQVSFQFIDSLWIGNLL GAKALGAAAVSSTIVLTVLSFILGLNNATLTILSQQKGKDDIKGMASYINAFVVLLTG LSIGFGAAGFFLSELLLRLLKTPESMIPLAETYLQIQFIGILFLFGYNFISTVLRALG DSKTPLRFIAFAVVLNTVLAPLFISVFRMGIAGAAYSTILSQGIAFLYGLFYVIKHKL VPFSIPRMPKWEESALILKLGIPAGLQMMVITGGMMAIMSVVNSYGDHVVSGFGAVQR LDSIITLPAMAAGTAVNSMAGQNIGIGNEKRVGTIARLGVIAVISCMLVIAVMIWVFG KYLIRLFISEPDAVAFGEQYLKWIAFFYPFIGVNFVLNGIVRAAGAMLQVLVLNLISF WVLRYPFTALFSAWLGQKGIGLGIGMSFLFSSCAAFLYYRYGRWKAMKLFTEK*" gene complement(2154267..2155604) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" CDS complement(2155676..2155870) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390055.1" /db_xref="EnsemblGenomes-Gn:BSU21720" /db_xref="EnsemblGenomes-Tr:CAB14090" /db_xref="GOA:P54180" /db_xref="InterPro:IPR035403" /db_xref="SubtiList:BG11624" /db_xref="UniProtKB/Swiss-Prot:P54180" /translation="MKRIYQYFSLLSFTFSLYFGWLAYHHLAAEDMDQMYLNVSYCAL FLSVMVFTFGMRDRKKTDKS*" gene complement(2155676..2155870) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" downshifts complement(2155689) /Source="Nicolas_upshifts" /id="D1137" /incds=0 /nref=123 /ntot=248 /MaxReadThrough="3.84998" /MaxDrop="4.80224" /score="-2.26655222" /energy="-15.5" /TU="U1705" /idTUdmin="U1707" /TUdmin=0 /isTUend="TRUE" CDS complement(2155883..2156446) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390056.1" /db_xref="EnsemblGenomes-Gn:BSU21730" /db_xref="EnsemblGenomes-Tr:CAB14091" /db_xref="GOA:P54179" /db_xref="InterPro:IPR018672" /db_xref="SubtiList:BG11623" /db_xref="UniProtKB/Swiss-Prot:P54179" /translation="MNKWKRLFFILLAINFILAAGFVALVLLPGEQAQVKDASESEYG FQVTSTKESLAAFVNSYLNDKASNKLDYKVEIDDDVHVAGKIKAFSTSIDAFIAFEPT VKKNGDVELNVTKFSLGKLSIPISFVLNYMDSFYELPSFVHVHPGDKSIEVRLSEMPL TNGMYVKADKINLEKDEIEFSYYHPKQ*" gene complement(2155883..2156446) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" CDS complement(2156456..2157223) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17220230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported lipase/acylhydrolase (lipoprotein)" /protein_id="NP_390057.1" /db_xref="EnsemblGenomes-Gn:BSU21740" /db_xref="EnsemblGenomes-Tr:CAB14092" /db_xref="GOA:P40766" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11022" /db_xref="UniProtKB/Swiss-Prot:P40766" /translation="MKLRIFSIMASLILLLTACTSIRTSSEGKQKAHETKTKEHIVIA AVGDSLTEGVGDPDGKGYVGKVADSIRSDKQVKTVDVKNYAVKGNRSDDLLEKLKDKK VQKGIKDADYVFFTIGGNDLMKILRQNFLQLTVEPFQEAEKPYEKRFEKIISEIRELN DHAELIYVSMYNPFTFTLSELNEINGVVTDWNHIAEKELKKDKHAKIVHIEDLFNQKS DSSRISEEDDFHPNGTGYSLIAKRVYQAIKKEGLPKE*" gene complement(2156456..2157223) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" promotor_-10 complement(2157247..2157266) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2157264) /Source="Nicolas_upshifts" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" promotor_-35 complement(2157277..2157284) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2157301..2157882) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10837475, 14680962, 14766920, 16305244, 19027886, 29131589" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10837475, 14680962, 14766920, 16305244, 19027886, 29131589; Product type f : factor" /codon_start=1 /transl_table=11 /product="assembly factor BSco of the Cu(A) site of cytochrome c oxidase" /protein_id="NP_390058.2" /db_xref="EnsemblGenomes-Gn:BSU21750" /db_xref="EnsemblGenomes-Tr:CAB14093" /db_xref="GOA:P54178" /db_xref="InterPro:IPR003782" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ON4" /db_xref="PDB:1XZO" /db_xref="SubtiList:BG11622" /db_xref="UniProtKB/Swiss-Prot:P54178" /translation="MKVIKGLTAGLIFLFLCACGGQQIKDPLNYEVEPFTFQNQDGKN VSLESLKGEVWLADFIFTNCETICPPMTAHMTDLQKKLKAENIDVRIISFSVDPENDK PKQLKKFAANYPLSFDNWDFLTGYSQSEIEEFALKSFKAIVKKPEGEDQVIHQSSFYL VGPDGKVLKDYNGVENTPYDDIISDVKSASTLK*" gene complement(2157301..2157882) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" S_feature complement(2157883..2157998) /Source="Nicolas_S_feature" /locus_tag="new_2292285_2292400_c" /HighExp="T5.0H, T3.30H, S2, T3.0H, BC, T2.30H, T4.0H, S1, HiOs, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S819" CDS complement(2158030..2158281) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15060025, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390059.1" /db_xref="EnsemblGenomes-Gn:BSU21760" /db_xref="EnsemblGenomes-Tr:CAB14094" /db_xref="InterPro:IPR019687" /db_xref="SubtiList:BG11621" /db_xref="UniProtKB/Swiss-Prot:P54177" /translation="MLLKSLEFKRGDGIQVKVTEIPVLKEDEHYFFMLHHHLQFYLKE VFSSNSRAKVYSFRHYMKRRMKWADYQAVFHQEVLKHNA*" gene complement(2158030..2158281) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" downshifts complement(2158043) /Source="Nicolas_upshifts" /id="D1138" /incds=0 /nref=2 /ntot=117 /MaxReadThrough="4.5803" /MaxDrop="2.91481" /score="26.0320926" /energy="-21.8" /TU="U1707" /idTUdmin="U1706" /TUdmin=0 /isTUend="TRUE" misc_feature complement(2158304..2158323) /Source="Nicolas_upshift_promotors" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2158318) /Source="Nicolas_upshifts" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" CDS complement(2158367..2159635) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" /EC_number="4.3.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine dehydratase" /protein_id="NP_390060.1" /db_xref="EnsemblGenomes-Gn:BSU21770" /db_xref="EnsemblGenomes-Tr:CAB14095" /db_xref="GOA:P37946" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001721" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011820" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10673" /db_xref="UniProtKB/Swiss-Prot:P37946" /translation="MKPLLKENSLIQVKDILKAHQNVKDVVIHTPLQRNDRLSERYEC NIYLKREDLQVVRSFKLRGAYHKMKQLSSEQTENGVVCASAGNHAQGVAFSCKHLGIH GKIFMPSTTPRQKVSQVELFGKGFIDIILTGDTFDDAYKSAAECCEAESRTFIHPFDD PDVMAGQGTLAVEILNDIDTEPHFLFASVGGGGLLSGVGTYLKNVSPDTKVIAVEPAG AASYFESNKAGHVVTLDKIDKFVDGAAVKKIGEETFRTLETVVDDILLVPEGKVCTSI LELYNECAVVAEPAGALSVAALDLYKDQIKGKNVVCVVSGGNNDIGRMQEMKERSLIF EGLQHYFIVNFPQRAGALREFLDEVLGPNDDITRFEYTKKNNKSNGPALVGIELQNKA DYGPLIERMNKKPFHYVEVNKDEDLFHLLI*" gene complement(2158367..2159635) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" promotor_-10 complement(2159669..2159688) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2159688) /Source="Nicolas_upshifts" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" promotor_-35 complement(2159700..2159707) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2159842..2159861 /Source="Nicolas_upshift_promotors" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2159845 /Source="Nicolas_upshifts" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" CDS 2159884..2160879 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12399512, 16585774, 19763274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399512, 16585774, 19763274; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional enhancer involved in BCAA homeostasis" /protein_id="NP_390061.1" /db_xref="EnsemblGenomes-Gn:BSU21780" /db_xref="EnsemblGenomes-Tr:CAB14096" /db_xref="GOA:P54156" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013668" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11619" /db_xref="UniProtKB/Swiss-Prot:P54156" /translation="MNSAPKLNTFQHLIGEHQTFLEAKRIAKQFSLSELPVLITGKIG TGKNHFAHAIHLESSRSNEPFISVNCSTHSEETLIHELFGPNGNTGVFQKAVRGTLFL DDVWRMPASVQAQLLKALDSDTEKPRMICASADRSVEHTFRQDLFYRLNILTLTLPEL SERKSDIPLLTQHFLSNSGQQLLIDPSVFPVLEKHAFEGNVRELKNAADYMAAVSSGG TIQPYDLPPYIRGTIDGKTSKKKAKLLTLMEKAEFLFILETIKVLNEKGEPASRRIIS EHSKNTQTSLTPQQVRSRLDYLEKKDYVTKSRGRAGTKITFEGLSFIETLKNQMI*" gene 2159884..2160879 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" CDS 2160900..2161541 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16585774, 16850406, 19763274; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_390062.1" /db_xref="EnsemblGenomes-Gn:BSU21790" /db_xref="EnsemblGenomes-Tr:CAB14097" /db_xref="GOA:P54175" /db_xref="InterPro:IPR004254" /db_xref="InterPro:IPR005744" /db_xref="SubtiList:BG11620" /db_xref="UniProtKB/Swiss-Prot:P54175" /translation="MFTIKEEIANAITHGIGVLLSIPALVFLIIFAANYGSAWDIVSF TIFGVSMLLLYLSSTLLHSITHKKTKDILEIIDHSAIYVLIAGTYTPFLLGPLKGTLG FTLLVIVWSLALGGIVFKIFFVKRFILLSTFVYLVMGWLMIIAVKPLYASLSGAGFSL LFLGGILYSVGTIFYIWKKIPFHHAIWHSFVLGGSAAMFFCVLFYCVKVPFLS*" gene 2160900..2161541 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" S_feature 2161542..2162643 /Source="Nicolas_S_feature" /locus_tag="new_2295944_2297045" /HighExp="Cold, C30, Sw, BC, G135, LoTm, Fru, C90, BI, S0" /AntisenseName="ypkP" /AntisenseCor="0.28434605181220002" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S820" CDS complement(2161580..2162200) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 1-acyl-sn-glycerol-3-phosphate acyltransferase" /protein_id="NP_390063.2" /db_xref="EnsemblGenomes-Gn:BSU21800" /db_xref="EnsemblGenomes-Tr:CAB14098" /db_xref="SubtiList:BG11618" /db_xref="UniProtKB/Swiss-Prot:P54174" /translation="MVRYSLLVVYIVYMLLKNMKQLFNQTMLDPRLSYKKQMALVYEQ PKAFLEGCIGISGSVVTIHQPEPIPHGPVLYVHPRLRLAELALIAGYIEEPAGFIANP KVFRLPFIGQWLDRMDVISDGDSEKVYEDVTKQLEKGQSLILSLDGSIDPVELAARYH LPLVMVETKGTDNMQNGSFFKRLKPADIELSFSKAYIPANEKQLRA*" gene complement(2161580..2162200) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" downshifts complement(2161606) /Source="Nicolas_upshifts" /id="D1139" /incds=0 /nref=72 /ntot=241 /MaxReadThrough="1.32187" /MaxDrop="5.02823" /score="16.0584527" /energy="-13.4" /TU="NA" /idTUdmin="U1710" /TUdmin="-21" /isTUend="TRUE" CDS complement(2162201..2162707) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" /EC_number="1.5.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2840350, 3918568, 10574451, 12682299, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2840350, 3918568, 10574451, 12682299, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydrofolate reductase" /protein_id="NP_390064.1" /db_xref="EnsemblGenomes-Gn:BSU21810" /db_xref="EnsemblGenomes-Tr:CAB14099" /db_xref="GOA:P11045" /db_xref="InterPro:IPR001796" /db_xref="InterPro:IPR012259" /db_xref="InterPro:IPR017925" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG10795" /db_xref="UniProtKB/Swiss-Prot:P11045" /translation="MISFIFAMDANRLIGKDNDLPWHLPNDLAYFKKITSGHSIIMGR KTFESIGRPLPNRKNIVVTSAPDSEFQGCTVVSSLKDVLDICSGPEECFVIGGAQLYT DLFPYADRLYMTKIHHEFEGDRHFPEFDESNWKLVSSEQGTKDEKNPYDYEFLMYEKK NSSKAGGF*" gene complement(2162201..2162707) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" CDS complement(2162704..2163498) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9648749, 10574451, 19732150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9648749, 10574451, 19732150; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase B" /protein_id="NP_390065.1" /db_xref="EnsemblGenomes-Gn:BSU21820" /db_xref="EnsemblGenomes-Tr:CAB14100" /db_xref="GOA:P11044" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="SubtiList:BG10794" /db_xref="UniProtKB/Swiss-Prot:P11044" /translation="MKQYKDFCRHVLEHGEKKGDRTGTGTISTFGYQMRFNLREGFPM LTTKKLHFKSIAHELLWFLKGDTNVRYLQENGVRIWNEWADENGELGPVYGSQWRSWR GADGETIDQISRLIEDIKTNPNSRRLIVSAWNVGEIDKMALPPCHCLFQFYVSDGKLS CQLYQRSADVFLGVPFNIASYALLTMIIAHVTGLEPGEFIHTFGDVHIYQNHIEQVNL QLERDVRPLPQLRFARKVDSIFNFAFEDFIIEDYDPHPHIKGAVSV*" gene complement(2162704..2163498) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" CDS complement(2163582..2164115) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8534098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_390066.1" /db_xref="EnsemblGenomes-Gn:BSU21830" /db_xref="EnsemblGenomes-Tr:CAB14101" /db_xref="GOA:P54173" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="PDB:1TLQ" /db_xref="SubtiList:BG11617" /db_xref="UniProtKB/Swiss-Prot:P54173" /translation="MKKYTMNEMVDITKDMLNKRGVMIEDIARIVQKLQEKYNPNLPL SVCMENVEKVLNKREIIHAVLTGLALDQLAEQKLLPEPLQHLVETDEPLYGIDEIIPL SIVNVYGSIGLTNFGYLDKEKIGIIKELDESPDGIHTFLDDIVAALAAAAASRIAHTH QDLQDEEKEQDEKPVVS*" gene complement(2163582..2164115) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" downshifts complement(2163587) /Source="Nicolas_upshifts" /id="D1140" /incds=0 /nref=17 /ntot=167 /MaxReadThrough="4.91561" /MaxDrop="4.18561" /score="15.5758445" /energy="-9.3" /TU="U1710" /idTUdmin="U1711" /TUdmin=1232 /isTUend="FALSE" promotor_-35 2164045..2164050 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2164061..2165007 /Source="Nicolas_S_feature" /locus_tag="new_2298463_2299409" /HighExp="S5, S6, S4, S8, S7, S3, B36, BT, B60, T5.0H" /AntisenseName="ypjP" /AntisenseCor="-0.72590712604537599" /AntisenseRegPval="-44.6" /CDS_PredictionProba="0.99932399999999999" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S821" upshifts 2164063 /Source="Nicolas_upshifts" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" promotor_-10 2164067..2164085 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2164133..2164744) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390067.1" /db_xref="EnsemblGenomes-Gn:BSU21840" /db_xref="EnsemblGenomes-Tr:CAB14102" /db_xref="GOA:P54172" /db_xref="InterPro:IPR025616" /db_xref="SubtiList:BG11616" /db_xref="UniProtKB/Swiss-Prot:P54172" /translation="MKLWMRKTLVVLFTIVTFGLVSPPAALMADKPSGQPSSLEQNDY TAFYDEHDLYDDESDDRRDPELLFQSYKEQLLDSAEDQSFLKFGSRIAPVIEDDYRKE ILPKIENVISDYLATLQDDEAYQDVVISSMPSAGKTEKIFNVYNRTTGEDLLRFHVRR DHPPHDGYWFNFHYHTAEDGFQSHHELGSIYWDRNTPPNWMSA*" gene complement(2164133..2164744) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" promotor_-10 complement(2164776..2164795) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2164795) /Source="Nicolas_upshifts" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" promotor_-35 complement(2164808..2164813) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2164964 /Source="Nicolas_upshifts" /id="D1141" /incds=0 /nref=57 /ntot=234 /MaxReadThrough="3.131" /MaxDrop="5.18613" /score="2.81720493" /energy="-15" /TU="U1709" /idTUdmin="U1709" /TUdmin="-527" /isTUend="FALSE" CDS complement(2165004..2165777) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" /EC_number="2.1.1.242" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22079366; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 16S rRNA m(2)G1516 methyltransferase" /protein_id="NP_390068.2" /db_xref="EnsemblGenomes-Gn:BSU21850" /db_xref="EnsemblGenomes-Tr:CAB14103" /db_xref="GOA:P54171" /db_xref="InterPro:IPR007536" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11615" /db_xref="UniProtKB/Swiss-Prot:P54171" /translation="MITTSYRPSEHTIKTAKQLSKELNMPYCGRNKQTVEHLLKSAER DLLVVGKERFELYTKQGAKFFFHPNTAMFRAKRFLQGEKEPMLRAAGLSEGDTFLDCT LGLGSDAIIASMAVGETGSVVGIEKNHLVSVLVRTGLHSWETGIEELQAAMRRIQVKN GDCFEHIKQLPDNSVDVVYFDPMFHEPVETSDGIAPLRDLAEDSVLHEGCINEAVRVA RKSVVLKDHWKSPRFEQFGFNVMKRKTALFHYGVIQTSP*" gene complement(2165004..2165777) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" downshifts complement(2165039) /Source="Nicolas_upshifts" /id="D1142" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="2.86923" /MaxDrop="2.91228" /score="9.10717118" /energy="-15" /TU="U1711" /idTUdmin="U1711" /TUdmin="-220" /isTUend="FALSE" CDS complement(2165819..2166253) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19653655, 21749987, 22938038, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19653655, 21749987, 22938038, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein disulfide isomerase; bacilliredoxin A (de-bacillithiolation)" /protein_id="NP_390069.1" /db_xref="EnsemblGenomes-Gn:BSU21860" /db_xref="EnsemblGenomes-Tr:CAB14104" /db_xref="InterPro:IPR009474" /db_xref="PDB:3FHK" /db_xref="SubtiList:BG11614" /db_xref="UniProtKB/Swiss-Prot:P54170" /translation="MSMAYEEYMRQLVVPMRRELTGAGFEELTTAEEVENFMEKAEGT TLVVVNSVCGCAAGLARPAATQAVLQNDKTPDNTVTVFAGQDKEATAKMREYFTGQEP SSPSMALLKGKEVVHFIPRHEIEGHDMEEIMKNLTAAFDAHC*" gene complement(2165819..2166253) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" downshifts complement(2165831) /Source="Nicolas_upshifts" /id="D1143" /incds=0 /nref=9 /ntot=210 /MaxReadThrough="5.2935" /MaxDrop="3.1992" /score="21.0933404" /energy="-9.7" /TU="U1711,U1712" /idTUdmin="U1712" /TUdmin="-462" /isTUend="FALSE" promotor_-10 complement(2166282..2166301) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-10" upshifts complement(2166293) /Source="Nicolas_upshifts" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" S_feature complement(2166295..2166359) /Source="Nicolas_S_feature" /locus_tag="new_2300697_2300761_c" /HighExp="Sw, S1, BC, Gly, HiOs, HiTm, GM-0.1, UNK1, Fru, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S822" promotor_-35 complement(2166315..2166322) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-35" downshifts complement(2166338) /Source="Nicolas_upshifts" /id="D1144" /incds=0 /nref=32 /ntot=128 /MaxReadThrough="5.73826" /MaxDrop="4.95094" /score="26.9702838" /energy="-25.8" /TU="U1712" /idTUdmin="U1713" /TUdmin="-1" /isTUend="TRUE" CDS complement(2166360..2168036) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" /EC_number="4.2.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12193635, 12618455, 15060025, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193635, 12618455, 15060025, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxy-acid dehydratase" /protein_id="NP_390070.2" /db_xref="EnsemblGenomes-Gn:BSU21870" /db_xref="EnsemblGenomes-Tr:CAB14105" /db_xref="GOA:P51785" /db_xref="InterPro:IPR000581" /db_xref="InterPro:IPR004404" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR020558" /db_xref="SubtiList:BG11532" /db_xref="UniProtKB/Swiss-Prot:P51785" /translation="MAELRSNMITQGIDRAPHRSLLRAAGVKEEDFGKPFIAVCNSYI DIVPGHVHLQEFGKIVKEAIREAGGVPFEFNTIGVDDGIAMGHIGMRYSLPSREIIAD SVETVVSAHWFDGMVCIPNCDKITPGMLMAAMRINIPTIFVSGGPMAAGRTSDGRKIS LSSVFEGVGAYQAGKINENELQELEQFGCPTCGSCSGMFTANSMNCLSEALGLALPGN GTILATSPERKEFVRKSAAQLMETIRKDIKPRDIVTVKAIDNAFALDMALGGSTNTVL HTLALANEAGVEYSLERINEVAERVPHLAKLAPASDVFIEDLHEAGGVSAALNELSKK EGALHLDALTVTGKTLGETIAGHEVKDYDVIHPLDQPFTEKGGLAVLFGNLAPDGAII KTGGVQNGITRHEGPAVVFDSQDEALDGIINRKVKEGDVVIIRYEGPKGGPGMPEMLA PTSQIVGMGLGPKVALITDGRFSGASRGLSIGHVSPEAAEGGPLAFVENGDHIIVDIE KRILDVQVPEEEWEKRKANWKGFEPKVKTGYLARYSKLVTSANTGGIMKI*" gene complement(2166360..2168036) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" S_feature complement(2168037..2168227) /Source="Nicolas_S_feature" /locus_tag="new_2302439_2302629_c" /HighExp="S1, T-5.40H, MG 45, HiOs, T-4.40H, MG 120, UNK1, MG 25, MG-0.2, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.97" /TUlongSig="SigH" /TUlongPSig=1 /label="S823" promotor_-10 complement(2168216..2168235) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2168227) /Source="Nicolas_upshifts" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" promotor_-35 complement(2168250..2168253) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2168325..2169458) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase or scaffold" /protein_id="NP_390071.1" /db_xref="EnsemblGenomes-Gn:BSU21880" /db_xref="EnsemblGenomes-Tr:CAB14106" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR014824" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR025989" /db_xref="InterPro:IPR036498" /db_xref="SubtiList:BG11613" /db_xref="UniProtKB/Swiss-Prot:P54169" /translation="MKIKSIEPTPSPNTMKVILTEELPAGKSNNYKPEQAEGAPLVIA EILKIDGVKGVYHVADFLAVERNARYDWKDILPQVRTAFGMESAESAEENRSDQESFG EVKVFVQMFSGIPMQVKLTDGEREERFGLPERFQQAILKLRSEASNVVFERAWKEQGV RFGDFDEIGHDVTEELQAAYSDERLKRLTEAAAQGKGEAKQAVQRKAYKVTLDMLDDE DWKKRYAHLEQMDPKEEDIPVLQKALDDPKVSIRRQAVVYLGMIETPDVLPLLYKALE DKAVSVRRTAGDCLSDIGDPQAIPAMIKSLSDSSKLVRWRAAMFLYEVGDESAIEALR AAEDDPEFEVSLQVKMALERIEHGEEAKGSVWKQMTESRKKGE*" gene complement(2168325..2169458) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" downshifts complement(2168341) /Source="Nicolas_upshifts" /id="D1145" /incds=0 /nref=193 /ntot=249 /MaxReadThrough="5.33526" /MaxDrop="6.88149" /score="18.2078317" /energy="-8.7" /TU="U1713" /idTUdmin="U1714" /TUdmin="-2" /isTUend="TRUE" misc_feature complement(2169480..2169499) /Source="Nicolas_upshift_promotors" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2169483) /Source="Nicolas_upshifts" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" CDS complement(2169518..2170135) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" /EC_number="3.6.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25005104, 27062940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25005104, 27062940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Mn(2+)-dependent (deoxy)ribonucleoside pyrophosphohydrolase" /protein_id="NP_390072.1" /db_xref="EnsemblGenomes-Gn:BSU21890" /db_xref="EnsemblGenomes-Tr:CAB14107" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11612" /db_xref="UniProtKB/Swiss-Prot:P54168" /translation="MKELKQAEQIRTWVQSILTDESSGHDWHHVSRVADLAAYIGEKE KADLFIVETAALVHDLIDVKLPDTVRLSVSEVYDQLVFFGVGKENADRVIHIITRMSF RDRGKLAKEPLSIEGKAVQDADRLDAIGAVGIARAFMFAGAKGHGLYGDEQSAYAHFF HKLLRLKDMMNTDTARELAEERHNFMLQFVRQLEKDIPGIDAETS*" gene complement(2169518..2170135) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" CDS complement(2170151..2170633) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" /EC_number="1.11.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14563871, 14617062, 21749987, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol peroxidase" /protein_id="NP_390073.1" /db_xref="EnsemblGenomes-Gn:BSU21900" /db_xref="EnsemblGenomes-Tr:CAB14108" /db_xref="GOA:P52035" /db_xref="InterPro:IPR000889" /db_xref="InterPro:IPR029759" /db_xref="InterPro:IPR029760" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11530" /db_xref="UniProtKB/Swiss-Prot:P52035" /translation="MSIYHMKVRTITGKDMTLQPFAGKVLMIVNTASKCGFTSQLKQL QELYDTYQQEGLEILGFPCNQFMNQEPGEEADIQEFCETNYGVTFPMFSKVDVNGKNA HPLFVYLTEHAKGMLGTKAIKWNFTKFIVDRNGEIVGRYSPNTNPKELEDDIVKLLEQ *" gene complement(2170151..2170633) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" S_feature complement(2170634..2170781) /Source="Nicolas_S_feature" /locus_tag="new_2305036_2305183_c" /HighExp="S2, HiOs, S1, Etha, T2.30H, T3.0H, Lbtran, M0t90, T2.0H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S824" promotor_-10 complement(2170772..2170790) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-10" upshifts complement(2170782) /Source="Nicolas_upshifts" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" promotor_-35 complement(2170801..2170809) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-35" promotor_-35 2170835..2170844 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 2170857..2170872 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" S_feature 2170859..2170945 /Source="Nicolas_S_feature" /locus_tag="new_2305261_2305347" /HighExp="Salt, T-0.40H, T-1.10H, Heat, T-1.40H, H2O2, T0.0H, Paraq, T0.30H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S825" upshifts 2170859 /Source="Nicolas_upshifts" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" promotor_-35 2170908..2170915 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 2170930..2170949 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" upshifts 2170947 /Source="Nicolas_upshifts" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" CDS 2170976..2171881 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" /EC_number="2.3.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5001847, 10939241, 11832514, 17056751, 18216013, 28581482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5001847, 10939241, 11832514, 17056751, 18216013, 28581482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="homoserine O-acetyltransferase" /protein_id="NP_390074.2" /db_xref="EnsemblGenomes-Gn:BSU21910" /db_xref="EnsemblGenomes-Tr:CAB14109" /db_xref="GOA:P54167" /db_xref="InterPro:IPR005697" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033752" /db_xref="SubtiList:BG11534" /db_xref="UniProtKB/Swiss-Prot:P54167" /translation="MPINIPTHLPAKQVLESEHIFVMDESRAFHQDIRPQKIIILNLM PKKIQTETQLLRLLGNSPLQVHFTFLIPSTHTPKNTAREHLDEFYTTFSNIRHKRFDG MIITGAPIEHLAFEEVSYWEELKEIMEWSKTNVTSTLHICWGAQAGLYYHYGVEKIQM PKKIFGVFEHTVLSKHERLVRGFDELYYVPHSRHTDINMEQLQAVPELNILTASKEAG VCLIVSKDEKQVFLTGHPEYDTNTLLQEYERDLERNLSTVEAPKHYFAKGSNEPVNRW KAHATLLFMNWLNYYVYQETPYEWD*" gene 2170976..2171881 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" misc_feature 2171916..2171935 /Source="Nicolas_upshift_promotors" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2171930 /Source="Nicolas_upshifts" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" S_feature 2171931..2172111 /Source="Nicolas_S_feature" /locus_tag="new_2306333_2306513" /HighExp="Heat, HiTm, LoTm, C90, M9-stat, HiOs, SMM, UNK1, MG 25, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="0.999, 0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S826" CDS 2172112..2173260 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" /EC_number="2.4.1.315" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose diacylglyceroltransferase" /protein_id="NP_390075.1" /db_xref="EnsemblGenomes-Gn:BSU21920" /db_xref="EnsemblGenomes-Tr:CAB14110" /db_xref="GOA:P54166" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR009695" /db_xref="InterPro:IPR023589" /db_xref="SubtiList:BG11611" /db_xref="UniProtKB/Swiss-Prot:P54166" /translation="MNTNKRVLILTANYGNGHVQVAKTLYEQCVRLGFQHVTVSNLYQ ESNPIVSEVTQYLYLKSFSIGKQFYRLFYYGVDKIYNKRKFNIYFKMGNKRLGELVDE HQPDIIINTFPMIVVPEYRRRTGRVIPTFNVMTDFCLHKIWVHENVDKYYVATDYVKE KLLEIGTHPSNVKITGIPIRPQFEESMPVGPIYKKYNLSPNKKVLLIMAGAHGVLKNV KELCENLVKDDQVQVVVVCGKNTALKESLSALEAENGDKLKVLGYVERIDELFRITDC MITKPGGITLTEATAIGVPVILYKPVPGQEKENANFFEDRGAAIVVNRHEEILESVTS LLADEDTLHRMKKNIKDLHLANSSEVILEDILKESEMMTAKQKAKVLS*" gene 2172112..2173260 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" S_feature complement(2172281..2173310) /Source="Nicolas_S_feature" /locus_tag="new_2306683_2307712_c" /HighExp="S8, S7, S6, C30, Lbstat, T0.30H, C90, BT, G135, Fru" /AntisenseName="ugtP" /AntisenseCor="-0.328222465122327" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S827" downshifts 2173256 /Source="Nicolas_upshifts" /id="D1146" /incds=0 /nref=77 /ntot=240 /MaxReadThrough="4.0787" /MaxDrop="4.20549" /score="21.6989702" /energy="-12.1" /TU="U1715,U1717" /idTUdmin="U1716" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2173292..2173311) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2173310) /Source="Nicolas_upshifts" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" promotor_-35 complement(2173326..2173334) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2173341..2173487 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513973.1" /translation="MELALLLKNKPFRNLTGAPRWCIVEPSFNNESKLDDDKIFFSTW VLQY*" gene 2173341..2173487 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" promotor_-35 2173380..2173387 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2173401..2173420 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2173412..2173502 /Source="Nicolas_S_feature" /locus_tag="new_2307814_2307904" /HighExp="C90, T5.0H, T3.30H, T3.0H, HiOs, Salt, LoTm, T-3.40H, S3, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S828" upshifts 2173412 /Source="Nicolas_upshifts" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" CDS 2173503..2173703 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9920884, 16352840" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9920884, 16352840; Product type f: factor" /codon_start=1 /transl_table=11 /product="cold-shock protein, molecular chaperone, RNA-helicase co-factor" /protein_id="NP_390076.1" /db_xref="EnsemblGenomes-Gn:BSU21930" /db_xref="EnsemblGenomes-Tr:CAB14111" /db_xref="GOA:P51777" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11531" /db_xref="UniProtKB/Swiss-Prot:P51777" /translation="MQNGKVKWFNNEKGFGFIEVEGGDDVFVHFTAIEGDGYKSLEEG QEVSFEIVEGNRGPQASNVVKL*" gene 2173503..2173703 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" downshifts 2173718 /Source="Nicolas_upshifts" /id="D1147" /incds=0 /nref=257 /ntot=269 /MaxReadThrough="5.19931" /MaxDrop="8.09346" /score="9.24662311" /energy="-15.6" /TU="U1719" /idTUdmin="U1715" /TUdmin=308 /isTUend="FALSE" CDS complement(2173755..2173937) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16625836, 19251843, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16625836, 19251843, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of degradative enzymes (aprE, nprE, sacB) production or activity" /protein_id="NP_390077.1" /db_xref="EnsemblGenomes-Gn:BSU21940" /db_xref="EnsemblGenomes-Tr:CAB14112" /db_xref="GOA:P68731" /db_xref="SubtiList:BG10699" /db_xref="UniProtKB/Swiss-Prot:P68731" /translation="MDDKDLKLILHKTFIEIYSDLEELADIAKKGKPSMEKYVEEIEQ RCKQNILAIEIQMKIK*" gene complement(2173755..2173937) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" S_feature 2173763..2174068 /Source="Nicolas_S_feature" /locus_tag="new_2308165_2308470" /HighExp="Cold, LoTm, T4.0H, T3.30H, Pyr, T5.0H, Gly, T3.0H, S0, C30" /AntisenseName="degR" /AntisenseCor="-0.145220711637392" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S829" downshifts complement(2173772) /Source="Nicolas_upshifts" /id="D1148" /incds=0 /nref=133 /ntot=216 /MaxReadThrough="3.75638" /MaxDrop="5.32427" /score="16.1392275" /energy="-7.3" /TU="U1720" /idTUdmin="U1720" /TUdmin="-22" /isTUend="TRUE" promotor_-10 complement(2173998..2174016) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2174030..2174036) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2174034) /Source="Nicolas_upshifts" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" promotor_-35 2174044..2174050 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2174065..2174076 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2174070 /Source="Nicolas_upshifts" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" CDS 2174093..2174362 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390078.1" /db_xref="EnsemblGenomes-Gn:BSU21950" /db_xref="EnsemblGenomes-Tr:CAB14113" /db_xref="InterPro:IPR020314" /db_xref="SubtiList:BG13764" /db_xref="UniProtKB/Swiss-Prot:O32007" /translation="MTSEFHNEDQTGFTDKRQLELAVETAQKTTGAATRGQSKTLVDS AYQAIEDARELSQSEELAALDDPEFVKQQQQLLDDSEHQLDEFKE*" gene 2174093..2174362 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" downshifts 2174217 /Source="Nicolas_upshifts" /id="D1149" /incds=1 /nref=3 /ntot=82 /MaxReadThrough="6.79633" /MaxDrop="4.11501" /score="22.0113838" /energy="-7.3" /TU="U1719,U1721" /idTUdmin="U1719" /TUdmin="-117" /isTUend="FALSE" downshifts 2174345 /Source="Nicolas_upshifts" /id="D1150" /incds=0 /nref=18 /ntot=94 /MaxReadThrough="2.31821" /MaxDrop="6.65627" /score="22.0113838" /energy="-7.3" /TU="NA" /idTUdmin="U1719" /TUdmin=11 /isTUend="TRUE" CDS complement(2174390..2174572) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390079.1" /db_xref="EnsemblGenomes-Gn:BSU21960" /db_xref="EnsemblGenomes-Tr:CAB14114" /db_xref="InterPro:IPR019718" /db_xref="SubtiList:BG11610" /db_xref="UniProtKB/Swiss-Prot:P54165" /translation="MDKKMIFKELTELHDEYCKDCFIKKQFRKEFGKTYAHSFCINKC TVGEKLKQYGDVLTNH*" gene complement(2174390..2174572) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" downshifts complement(2174410) /Source="Nicolas_upshifts" /id="D1151" /incds=0 /nref=5 /ntot=102 /MaxReadThrough="2.77117" /MaxDrop="4.29218" /score="16.1392275" /energy="-7.3" /TU="NA" /idTUdmin="U1723" /TUdmin=0 /isTUend="TRUE" CDS complement(2174565..2175245) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12562816, 17905985, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 17905985, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease" /protein_id="NP_390080.2" /db_xref="EnsemblGenomes-Gn:BSU21970" /db_xref="EnsemblGenomes-Tr:CAB14115" /db_xref="GOA:P54164" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11609" /db_xref="UniProtKB/Swiss-Prot:P54164" /translation="MKLRPHLKIEAKGTGSVSFFSEDWLTAQQARTFARELGRFPYMK ELEFEDEKGGSWTLKELEKLTEELAQEPDDITVYFDGSFDKESELAGLGIVIYYSLGG TRHRLRKNKSFRLKTNNEAEYAALYEAIREVRELGASRNSITIKGDSLVVLNQLDGSW PCYDPSHNEWLDKIEALLESLKLTPTYETIQRKDNQEADGLAKKILSHQFVESHTKLD RNGDDDIG*" gene complement(2174565..2175245) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" S_feature complement(2175246..2175383) /Source="Nicolas_S_feature" /locus_tag="new_2309648_2309785_c" /HighExp="S5, S4, S6, S8, S7, S3, T5.0H, T4.0H, BT, Pyr" /AntisenseName="ypdP" /AntisenseCor="-0.65324924042743404" /AntisenseRegPval="-33.4" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.92, 0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S830" promotor_-35 2175262..2175267 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2175280..2175299 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2175285 /Source="Nicolas_upshifts" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" CDS 2175328..2176017 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28208705; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preQ0 transporter (promiscuous)" /protein_id="NP_390081.1" /db_xref="EnsemblGenomes-Gn:BSU21980" /db_xref="EnsemblGenomes-Tr:CAB14116" /db_xref="GOA:P54163" /db_xref="InterPro:IPR003744" /db_xref="SubtiList:BG11607" /db_xref="UniProtKB/Swiss-Prot:P54163" /translation="MFNNSFWIFFAIIHFIIVLLFYKGFGKMGLFVWIGFATVCANLQ VVKTVELFGLTATLGNVMYGTIFFATDVLNEKYGPAEARKAVWLGFSTLLTLTFVMQG VLLFEPASSDISQTALETIFGFLPRVALGSLLAFIFSQTLDVYVYSAIRRIFPSDRLL WLRNGGSTAVSQLFDTFIFTAVAFLGIYPADVWLHIFISTYLIKFAVSLISLPYAYAA KKMIPNDERSS*" gene 2175328..2176017 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" promotor_-10 complement(2175378) /Source="Nicolas_upshift_promotors" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2175381..2175397) /Source="Nicolas_upshift_promotors" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2175384) /Source="Nicolas_upshifts" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" S_feature complement(2175385..2175774) /Source="Nicolas_S_feature" /locus_tag="new_2309787_2310176_c" /HighExp="S5, S4, S6, S7, S8, T5.0H, S3, T4.0H, BT, M9-stat" /AntisenseName="ypdP" /AntisenseCor="-0.645700204826543" /AntisenseRegPval="-32.4" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S831" promotor_-10 complement(2175755..2175774) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2175772) /Source="Nicolas_upshifts" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" promotor_-35 complement(2175786..2175794) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2176017..2176415 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9888800, 10094689, 15115438, 17905985; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein (no RNase H activity)" /protein_id="NP_390082.1" /db_xref="EnsemblGenomes-Gn:BSU21990" /db_xref="EnsemblGenomes-Tr:CAB14117" /db_xref="GOA:P54162" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11608" /db_xref="UniProtKB/Swiss-Prot:P54162" /translation="MPTEIYVDGASAGNPGPSGIGIFIKHEGKAESFSIPIGVHTNQE AEFLALIEGMKLCATRGYQSVSFRTDSDIVERATELEMVKNITFQPFVEEIIRLKAAF PLFFIKWIPGKQNQKADLLAKEAIRLNEKN*" gene 2176017..2176415 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" promotor_-35 2176408..2176414 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2176429..2176440 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2176440 /Source="Nicolas_upshifts" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" CDS 2176457..2176585 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054584.1" /db_xref="EnsemblGenomes-Gn:BSU22000" /db_xref="EnsemblGenomes-Tr:CAE01458" /db_xref="GOA:Q7WY66" /db_xref="InterPro:IPR017526" /db_xref="SubtiList:BG14176" /db_xref="UniProtKB/Swiss-Prot:Q7WY66" /translation="MKKKDKGRLTGGVTPQGDLEGNTHNDPKTELEERAKKSNTKR*" gene 2176457..2176585 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" S_feature 2176586..2177566 /Source="Nicolas_S_feature" /locus_tag="new_2310988_2311968" /HighExp="S8, S7, S5, S6, S4, C30, nit, ferm, Pyr, S3" /AntisenseName="exoA" /AntisenseCor="-0.365099613028674" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S832" CDS complement(2176593..2177483) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:16045613, 17038322, 17905985, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16045613, 17038322, 17905985, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5'3'-exonuclease" /protein_id="NP_390083.1" /db_xref="EnsemblGenomes-Gn:BSU22010" /db_xref="EnsemblGenomes-Tr:CAB14118" /db_xref="GOA:P54161" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="SubtiList:BG11606" /db_xref="UniProtKB/Swiss-Prot:P54161" /translation="MNNNKLLLVDGMALLFRAFFATAVHRNFMINDSGVPTNGVNGFL KHLITAVETFQPTHVVCCWDMGSKTYRNDLFQDYKANRSAPPVELIPQFDLAKEAAAE LGIMNIGFAGYEADDCIGTLADLFANEADITVVTGDRDLLQLLTDKVSVALLQKGIGN YKVYTKETFYEETGVMPKALIDIKALMGDSSDNYPGVKGIGEKTAYKLIREYETIDRL LENLSLLPKGQQGKIQQGLSDLEMSRKLAEIHCSVPLACTLKDALFTLQMEQAADMLR RHQIKGIERMLEKLNAREIV*" gene complement(2176593..2177483) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" downshifts complement(2176630) /Source="Nicolas_upshifts" /id="D1152" /incds=0 /nref=10 /ntot=174 /MaxReadThrough="2.94148" /MaxDrop="4.49836" /score="3.60870815" /energy="-15.6" /TU="U1726" /idTUdmin="U1726" /TUdmin="-284" /isTUend="FALSE" promotor_-10 complement(2177505..2177524) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2177512) /Source="Nicolas_upshifts" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" promotor_-35 complement(2177536..2177542) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2177540 /Source="Nicolas_upshifts" /id="D1153" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="0.83304" /MaxDrop="4.41573" /score="0.126370352" /energy="-15" /TU="NA" /idTUdmin="U1725" /TUdmin=16 /isTUend="TRUE" CDS complement(2177584..2177730) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097753.1" /db_xref="EnsemblGenomes-Gn:BSU22019" /db_xref="EnsemblGenomes-Tr:CAX52652" /db_xref="UniProtKB/Swiss-Prot:C0H443" /translation="MLGRTKLGNRNAQANNNAKKKNGFQTHFDSYAGREAEKLIASNK RHND*" gene complement(2177584..2177730) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" downshifts complement(2177600) /Source="Nicolas_upshifts" /id="D1154" /incds=0 /nref=253 /ntot=272 /MaxReadThrough="0.89691" /MaxDrop="8.47168" /score="25.632979" /energy="-12" /TU="NA" /idTUdmin="U1727" /TUdmin=0 /isTUend="TRUE" upshifts complement(2177754) /Source="Nicolas_upshifts" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" promotor_-10 complement(2177755..2177766) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2177781..2177787) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2177805..2178062) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" /experiment="publication(s) with functional evidences, PMID:20709900, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore associated protein" /protein_id="NP_390084.1" /db_xref="EnsemblGenomes-Gn:BSU22020" /db_xref="EnsemblGenomes-Tr:CAB14119" /db_xref="InterPro:IPR019688" /db_xref="SubtiList:BG11605" /db_xref="UniProtKB/Swiss-Prot:P54160" /translation="MSEVHKAISAHSSKQHEHIKAFMRLENMRELAIEEAVAKCRNDE PYTTDAINEITEQMNQLAKKGIVPTRRLVSKEMVREYVSRM*" gene complement(2177805..2178062) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" promotor_-10 complement(2178082..2178101) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2178097) /Source="Nicolas_upshifts" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" promotor_-35 complement(2178113..2178120) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2178127..2181708) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" /EC_number="3.6.5.5" /experiment="publication(s) with functional evidences, PMID:21205012, 23388828, 23249255, 26842743, 26530236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21205012, 23388828, 23249255, 26842743, 26530236; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dynamin GTPase" /protein_id="NP_390085.1" /db_xref="EnsemblGenomes-Gn:BSU22030" /db_xref="EnsemblGenomes-Tr:CAB14120" /db_xref="GOA:P54159" /db_xref="InterPro:IPR022812" /db_xref="InterPro:IPR027094" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11604" /db_xref="UniProtKB/Swiss-Prot:P54159" /translation="MTDQNRKELLHKTGELYKQFIENQDEQRAAKLAAVMKKAADEEV YIAFTGHYSAGKSSLLNCLLMENILPTSPIPTSANLVVIRNGEKRVRLHTTDGACAEL EGTYQKDKVQQYCKDGEQIESVEIFDRYTEIDSGVAYIDTPGIDSTDDAHFLSAASIL HQADALFYVVHYNHVHAEENVKFLRSIKESIPNVYFIVNQIDRHDETETKFGDYQAQV EEMLCNEGISREALYFTSVTEPDHPFNQMGALREELSRIEQQSKSNMQALTEQKVRNL LKEHTEMLKKDETGAPSFAEQLNIHTGLVQSLRDQLDEAEKQMTEAEKRMQEEINRIL KNANLTPFEMRELAAAFLESQEPSFKTGFFFSKAKTAQERDKRRNAFFSDVAKRTEAE ADWHMIDTLHKLAKVFDVYTAESEKLIQAYRTPLDISIIEHAVKHGAAFSSEYVLQYT KDLAELIRKEAKREAADIIKVLSAMVKERVSKDVQTINDRLVQESEKLVFLQEQARLE NNAREKTDRLWAIWEEESACPMHIDTEWFKSKKTRVAAPEQKQGRSQLTAQPMPKSEI KMEQEMPLQDQIKRFYTLSDILGECSMLLKQTSAFRERVKRLEERKFTLALFGGFSSG KSSFANALVGERVLPSSPTPTTATINKITKPINGNLNKTANVVFKTEDDLTAEILQLT GIPKEPAGRSFTEKWEKAVKKNRLQEEHVKLISNFLLAYEKYQQYIQEQKKLTIPLSE LKPYVAEETTACAVKEVTVYYTCPLTEKGITIVDTPGASSMNKRHTELAFQYIKDADA FFYMTYYQHSFSKGDRSFLRKLGLVKESLSMDKMFFIINAADLAKDKTELETVTDYVS AELVKEGVYEPQLFTVSSKEELVGKPESFYNQFSKVRKHLDRFIEVDVKKASAAQLSS EADKLCETVFQLHQSQHQSREEKEAQKQCLMLSFERTAADIEKRRNSKTIIEKVKKDT REQLYHIAQRLSYFANDLLKSAFHPGLQNGDWKKNVSKAMTTALHEYLFEYIQEIKTL DVRMSGFIERHINEEWLDHFQKTLNEDGYFSVYAGDQHSNGIQLKEVEPEIEERAFEQ ELKEIKSPKQFFEQKGKATFIEAVRMKLTKITEAWIKNEEESLISHYTAHLRRLQEDM GEKAIAQITDQKETYLRGYAEGEHAKEIEMAYQACISWKNSDNTIKM*" gene complement(2178127..2181708) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" S_feature complement(2181709..2181780) /Source="Nicolas_S_feature" /locus_tag="new_2316111_2316182_c" /HighExp="LBGstat, T1.30H, T1.0H, BMM, T2.30H, M9-stat, MG 150, T0.30H, T2.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S833" misc_feature complement(2181770..2181789) /Source="Nicolas_upshift_promotors" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2181780) /Source="Nicolas_upshifts" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" S_feature complement(2181825..2182022) /Source="Nicolas_S_feature" /locus_tag="new_2316227_2316424_c" /HighExp="HiOs, B60, GM 25, S7, GM 15, B36, S5, S8, GM 5, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.24118200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S834" downshifts complement(2181868) /Source="Nicolas_upshifts" /id="D1155" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.11615" /MaxDrop="3.46525" /score="27.1937922" /energy="-9.7" /TU="U1730" /idTUdmin="U1730" /TUdmin="-22" /isTUend="TRUE" CDS complement(2181884..2181973) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513974.1" /db_xref="EnsemblGenomes-Gn:BSU22036" /db_xref="EnsemblGenomes-Tr:CCQ48599" /db_xref="UniProtKB/TrEMBL:L8ECR0" /translation="MTMLFLLGAVCTYSVLIGFVLKGISNKSV*" gene complement(2181884..2181973) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" promotor_-10 complement(2182001..2182020) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2182022) /Source="Nicolas_upshifts" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" promotor_-35 complement(2182035..2182042) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2182044..2182550) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" /EC_number="2.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 7726551, 8396117, 19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 7726551, 8396117, 19465653; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alkylpyrone methyltransferase (polyketide synthesis)" /protein_id="NP_390086.1" /db_xref="EnsemblGenomes-Gn:BSU22040" /db_xref="EnsemblGenomes-Tr:CAB14121" /db_xref="GOA:P54158" /db_xref="InterPro:IPR007269" /db_xref="SubtiList:BG11603" /db_xref="UniProtKB/Swiss-Prot:P54158" /translation="MFWLLIAILIVQRAAEMAVARQNEQKVKKQGAIEFGESHYPYII TMHILFFLSLIAEVLLMNKQPSSWWLGIAAVILSVQIVRYWALCSLGAYWNTKILVVP GVELVKKGPYKWMKHPNYAVVILEILLIPLLYQAYVTMCLFSIFNAVLLSVRIRAEDK ALQEYSVK*" gene complement(2182044..2182550) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" CDS complement(2182554..2183651) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" /EC_number="2.3.1.-" /function="15.10: Adaptations to atypical conditions" /experiment="publication(s) with functional evidences, PMID:19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19465653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous alkylpyrone synthase BpsA (polyketide synthesis)" /protein_id="NP_390087.1" /db_xref="EnsemblGenomes-Gn:BSU22050" /db_xref="EnsemblGenomes-Tr:CAB14122" /db_xref="GOA:P54157" /db_xref="InterPro:IPR001099" /db_xref="InterPro:IPR011141" /db_xref="InterPro:IPR012328" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR018088" /db_xref="SubtiList:BG11523" /db_xref="UniProtKB/Swiss-Prot:P54157" /translation="MAFILSIGTSLPAYNVNQEKAAEFARYMFQHSFKDIDRLLSSFK NGQIHSRQFVKPIEWYKEGHSFEEKNQIYIEETLKHSRAAVRECLSHPEFFQEAIPYE KVEAVFFVSSTGLSTPSIEARLMNELPFSPYTKRIPIWGLGCAGGASGLARAAEYCKA YPEAFVLVISAELCSLTFQPEDKTKSNLIGTSLFGDGIAAALLCGEKADRRVSKLKLA PKIMDAQSVLMKQSEDVMGWDFTDQGFKVIFSRDIPTLVEKWLKTNVQIFLDKHKLSF HDISVFLAHPGGKKVIDAYIKSLGLSSEKLSSAQSILQKHGNMSSATILYVIKDHLQN GHKKEAERGLIGALGPGFSSELLLFSWEKGA*" gene complement(2182554..2183651) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" promotor_-10 complement(2183669..2183680) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2183672) /Source="Nicolas_upshifts" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" promotor_-35 complement(2183695..2183701) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2183725..2185041) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098051, 12923093, 15549109, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098051, 12923093, 15549109, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xanthine permease" /protein_id="NP_390088.1" /db_xref="EnsemblGenomes-Gn:BSU22060" /db_xref="EnsemblGenomes-Tr:CAB14123" /db_xref="GOA:P42086" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG11080" /db_xref="UniProtKB/Swiss-Prot:P42086" /translation="MRNGFGKTLSLGIQHVLAMYAGAIVVPLIVGKAMGLTVEQLTYL VSIDIFMCGVATLLQVWSNRFFGIGLPVVLGCTFTAVSPMIAIGSEYGVSTVYGSIIA SGILVILISFFFGKLVSFFPPVVTGSVVTIIGITLMPVAMNNMAGGEGSADFGDLSNL ALAFTVLSIIVLLYRFTKGFIKSVSILIGILIGTFIAYFMGKVQFDNVSDAAVVQMIQ PFYFGAPSFHAAPIITMSIVAIVSLVESTGVYFALGDLTNRRLTEIDLSKGYRAEGLA VLLGGIFNAFPYTAFSQNVGLVQLTGIKKNAVIVVTGVILMAFGLFPKIAAFTTIIPS AVLGGAMVAMFGMVIAYGIKMLSRIDFAKQENLLIVACSVGLGLGVTVVPDIFKQLPS ALTLLTTNGIVAGSFTAVVLNIVYNVFSKAKKIEQEADLAEQKTAV*" gene complement(2183725..2185041) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" downshifts complement(2183738) /Source="Nicolas_upshifts" /id="D1156" /incds=0 /nref=177 /ntot=215 /MaxReadThrough="1.81377" /MaxDrop="6.3089" /score="32.8866099" /energy="-9" /TU="U1733" /idTUdmin="U1732" /TUdmin=0 /isTUend="TRUE" CDS complement(2185038..2185622) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" /EC_number="2.4.2.22" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12923093, 15549109, 19381559, 20108980, 20200045" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923093, 15549109, 19381559, 20108980, 20200045; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine phosphoribosyltransferase" /protein_id="NP_390089.1" /db_xref="EnsemblGenomes-Gn:BSU22070" /db_xref="EnsemblGenomes-Tr:CAB14124" /db_xref="GOA:P42085" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010079" /db_xref="InterPro:IPR029057" /db_xref="PDB:1Y0B" /db_xref="PDB:2FXV" /db_xref="SubtiList:BG11079" /db_xref="UniProtKB/Swiss-Prot:P42085" /translation="MEALKRKIEEEGVVLSDQVLKVDSFLNHQIDPLLMQRIGDEFAS RFAKDGITKIVTIESSGIAPAVMTGLKLGVPVVFARKHKSLTLTDNLLTASVYSFTKQ TESQIAVSGTHLSDQDHVLIIDDFLANGQAAHGLVSIVKQAGASIAGIGIVIEKSFQP GRDELVKLGYRVESLARIQSLEEGKVSFVQEVHS*" gene complement(2185038..2185622) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" misc_RNA complement(2185711..2185811) /gene="gswA" /locus_tag="BSU_misc_RNA_34" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" gene complement(2185711..2185811) /gene="gswA" /locus_tag="BSU_misc_RNA_34" downshifts complement(2185718) /Source="Nicolas_upshifts" /id="D1157" /incds=0 /nref=8 /ntot=35 /MaxReadThrough="6.97435" /MaxDrop="3.25" /score="36.5247418" /energy="-19.2" /TU="U1732,U1733" /idTUdmin="U1734" /TUdmin=1870 /isTUend="FALSE" S_feature complement(2185812..2185952) /Source="Nicolas_S_feature" /locus_tag="new_2320214_2320354_c" /HighExp="dia15, BT, dia5, Diami, C90, LBGtran, Lbtran, Gly, SMMPr, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.291, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S835" CDS complement(2185953..2187458) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" /EC_number="3.4.17.19" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7765282, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="metal-dependent carboxypeptidase" /protein_id="NP_390090.1" /db_xref="EnsemblGenomes-Gn:BSU22080" /db_xref="EnsemblGenomes-Tr:CAB14125" /db_xref="GOA:P50848" /db_xref="InterPro:IPR001333" /db_xref="PDB:3HQ2" /db_xref="SubtiList:BG11458" /db_xref="UniProtKB/Swiss-Prot:P50848" /translation="MEIHTYEKEFFDLLKRISHYSEAVALMHWDSRTGAPKNGSEDRA ESIGQLSTDIFNIQTSDRMKELIDVLYERFDDLSEDTKKAVELAKKEYEENKKIPEAE YKEYVILCSKAETAWEEAKGKSDFSLFSPYLEQLIEFNKRFITYWGYQEHPYDALLDL FEPGVTVKVLDQLFAELKEAIIPLVKQVTASGNKPDTSFITKAFPKEKQKELSLYFLQ ELGYDFDGGRLDETVHPFATTLNRGDVRVTTRYDEKDFRTAIFGTIHECGHAIYEQNI DEALSGTNLSDGASMGIHESQSLFYENFIGRNKHFWTPYYKKIQEASPVQFKDISLDD FVRAINESKPSFIRVEADELTYPLHIIIRYEIEKAIFSNEVSVEDLPSLWNQKYQDYL GITPQTDAEGILQDVHWAGGDFGYFPSYALGYMYAAQLKQKMLEDLPEFDALLERGEF HPIKQWLTEKVHIHGKRKKPLDIIKDATGEELNVRYLIDYLSNKYSNLYLL*" gene complement(2185953..2187458) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" promotor_no_box complement(2187394..2187494) /Source="Nicolas_upshift_promotors" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2187434) /Source="Nicolas_upshifts" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" downshifts 2187446 /Source="Nicolas_upshifts" /id="D1158" /incds=0 /nref=4 /ntot=78 /MaxReadThrough="1.34397" /MaxDrop="3.87399" /score="12.6922524" /energy="-13.3" /TU="NA" /idTUdmin="U1735" /TUdmin="-5588" /isTUend="FALSE" promotor_-10 complement(2187484..2187503) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2187500) /Source="Nicolas_upshifts" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" promotor_-35 complement(2187517..2187524) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2187570..2188562) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 9846747; Product type t: transporter" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate permease" /protein_id="NP_390091.1" /db_xref="EnsemblGenomes-Gn:BSU22090" /db_xref="EnsemblGenomes-Tr:CAB14126" /db_xref="GOA:P50847" /db_xref="InterPro:IPR004684" /db_xref="InterPro:IPR018395" /db_xref="SubtiList:BG11399" /db_xref="UniProtKB/Swiss-Prot:P50847" /translation="MKIKATIERVPGGMMIIPLFLGAALNTFAPGTAEFFGGFTGALI TGTLPILGVFIFCVGATIDFRSSGYIARKGITLLLGKIGFAALLGVIAAQFIPDDGIQ SGFFAGLSVLAIVAVMNETNGGLYLALMNHMGRKEDAGAFAFISTESGPFMTMVTFGV TGLAAFPWETLAATVIPFLLGCILGNLDHDLRDLFSKVVPAIIPFFAFSLGNTLNFGM LIQSGLLGIFIGVSVVILSGSSLFLLDRFIARGDGVAGVAASSTAGAAVAVPYALAEA NASFAPVAESATAIIATSVIVTSLLTPLATVWVDKKIKQKKRRTPPPKNQMTIN*" gene complement(2187570..2188562) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" downshifts complement(2187588) /Source="Nicolas_upshifts" /id="D1159" /incds=0 /nref=15 /ntot=59 /MaxReadThrough="3.32882" /MaxDrop="5.85236" /score="36.5247418" /energy="-19.2" /TU="NA" /idTUdmin="U1734" /TUdmin=0 /isTUend="TRUE" CDS complement(2188607..2189197) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" /EC_number="4.1.2.14" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate-6-phosphate aldolase" /protein_id="NP_390092.1" /db_xref="EnsemblGenomes-Gn:BSU22100" /db_xref="EnsemblGenomes-Tr:CAB14127" /db_xref="GOA:P50846" /db_xref="InterPro:IPR000887" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031338" /db_xref="SubtiList:BG11396" /db_xref="UniProtKB/Swiss-Prot:P50846" /translation="MESKVVENRLKEAKLIAVIRSKDKQEACQQIESLLDKGIRAVEV TYTTPGASDIIESFRNREDILIGAGTVISAQQAGEAAKAGAQFIVSPGFSADLAEHLS FVKTHYIPGVLTPSEIMEALTFGFTTLKLFPSGVFGIPFMKNLAGPFPQVTFIPTGGI HPSEVPDWLRAGAGAVGVGSQLGSCSKEDLQAVFQV*" gene complement(2188607..2189197) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" CDS complement(2189199..2190173) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" /EC_number="2.7.1.45" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143, 15039578; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate kinase" /protein_id="NP_390093.1" /db_xref="EnsemblGenomes-Gn:BSU22110" /db_xref="EnsemblGenomes-Tr:CAB14128" /db_xref="GOA:P50845" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG11397" /db_xref="UniProtKB/Swiss-Prot:P50845" /translation="MKLDAVTFGESMAMFYANEYGGLHEVSTFSKGLAGAESNVACGL ARLGFRMGWMSKVGNDQLGTFILQELKKEGVDVSRVIRSQDENPTGLLLKSKVKEGDP QVTYYRKNSAASTLTTAEYPRDYFQCAGHLHVTGIPPALSAEMKDFTYHVMNDMRNAG KTISFDPNVRPSLWPDQATMVHTINDLAGLADWFFPGIAEGELLTGEKTPEGIADYYL KKGASFVAIKLGKEGAYFKTGTSEGFLEGCRVDRVVDTVGAGDGFAVGVISGILDGLS YKDAVQRGNAIGALQVQAPGDMDGLPTREKLASFLSAQRTVHQKKGDY*" gene complement(2189199..2190173) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" CDS complement(2190211..2191230) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9846747, 15223311, 17322190, 28040177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9846747, 15223311, 17322190, 28040177; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the Kdg operon (KdgR-galacturonate)" /protein_id="NP_390094.1" /db_xref="EnsemblGenomes-Gn:BSU22120" /db_xref="EnsemblGenomes-Tr:CAB14129" /db_xref="GOA:P50844" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG11398" /db_xref="UniProtKB/Swiss-Prot:P50844" /translation="MKKKTTGHTTIKDVAECAGVSKSTVSRYINGKIDAISPEKVKNI KKAIAELNYRPSKMAQGLKIKKSKLIGFVVADITNPFSVAAFRGVEEVCDQYGYSIMV CNTDNSPEKEREMLLKLEAHSVEGLILNATGENKDVLRAFAEQQIPTILIDRKLPDLK LDTVTTDNRWITKEILQKVYSKGYTDVALFTEPISSISPRAERAAVYQEMASVQNVNG LVRLHEIDVKDKEQLKAELRSFHKEMPEQKKAILALNGLIMLKIISCMEELGLRIPQD IGIAGFDDTEWYKLIGPGITTIAQPSHDMGRTAMERVLKRIEGDKGAPQTIELEAKVI MRKSL*" gene complement(2190211..2191230) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" promotor_-10 complement(2191278..2191297) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2191288) /Source="Nicolas_upshifts" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" promotor_-35 complement(2191309..2191316) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2191351..2191358 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2191372..2191451 /Source="Nicolas_S_feature" /locus_tag="new_2325774_2325853" /HighExp="HiTm, Heat, nit, LBGstat, ferm, T-0.40H, HiOs, T1.30H, MG 150, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S836" upshifts 2191372 /Source="Nicolas_upshifts" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" promotor_-10 2191373..2191392 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2191452..2192279 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" /EC_number="5.3.1.17" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 23437267, 27227414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase, 5-keto-4-deoxyuronate isomerase" /protein_id="NP_390095.1" /db_xref="EnsemblGenomes-Gn:BSU22130" /db_xref="EnsemblGenomes-Tr:CAB14130" /db_xref="GOA:P50843" /db_xref="InterPro:IPR007045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR021120" /db_xref="InterPro:IPR027449" /db_xref="SubtiList:BG11401" /db_xref="UniProtKB/Swiss-Prot:P50843" /translation="MENRYSVHPEQVKRFTTEELRSHFLMDSLFTENKLTMYYSHEDR VVIGGAAPGQSELKLDAGDFLKTDFFLERREIGIINVGQPGAVRVGDDEYVLQTKDFL YIGMGNQDVSFSSLNGEKAKFYFVSACAHKSYPTQKAALSELTPDRLGDDAASNVRSL YKVIHQDGIKSCQLMMGITMLDQNNNWNTMPAHVHDRRMEAYLYLDLEKDSKVFHFMG QPDETRHLVVGNEQAVLSPAWSIHSGAGTSNYSFVWAMAGENYTFTDMDLIPMDGLK* " gene 2191452..2192279 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" CDS 2192281..2193045 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" /EC_number="1.1.1.127" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 24509771, 27028675; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate oxidoreductase" /protein_id="NP_390096.1" /db_xref="EnsemblGenomes-Gn:BSU22140" /db_xref="EnsemblGenomes-Tr:CAB14131" /db_xref="GOA:P50842" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011286" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11400" /db_xref="UniProtKB/Swiss-Prot:P50842" /translation="MGYLHDAFSLKGKTALVTGPGTGIGQGIAKALAGAGADIIGTSH TSSLSETQQLVEQEGRIFTSFTLDMSKPEAIKDSAAELFENRQIDILVNNAGIIHREK AEDFPEENWQHVLNVNLNSLFILTQLAGRHMLKRGHGKIINIASLLSFQGGILVPAYT ASKHAVAGLTKSFANEWAASGIQVNAIAPGYISTANTKPIRDDEKRNEDILKRIPAGR WGQADDIGGTAVFLASRASDYVNGHILAVDGGWLSR*" gene 2192281..2193045 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" downshifts 2193034 /Source="Nicolas_upshifts" /id="D1160" /incds=0 /nref=12 /ntot=160 /MaxReadThrough="0.66029" /MaxDrop="3.56178" /score="23.0070487" /energy="-12.3" /TU="NA" /idTUdmin="U1735" /TUdmin=0 /isTUend="TRUE" downshifts complement(2193076) /Source="Nicolas_upshifts" /id="D1161" /incds=0 /nref=28 /ntot=225 /MaxReadThrough="1.88107" /MaxDrop="5.27501" /score="35.5168663" /energy="-12.3" /TU="NA" /idTUdmin="U1736" /TUdmin="-10" /isTUend="TRUE" CDS complement(2193086..2195011) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" /EC_number="3.6.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8385320, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent helicase" /protein_id="NP_390097.1" /db_xref="EnsemblGenomes-Gn:BSU22150" /db_xref="EnsemblGenomes-Tr:CAB14132" /db_xref="GOA:P50831" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11457" /db_xref="UniProtKB/Swiss-Prot:P50831" /translation="MTTSRLPFSLTKTKNFYEELNNWIGDVFYDILPEKGFDLRDEQV FMAFQLERAFKEKKVMFAEAGVGTGKTLVYLLFAISYARYVGKPAIIACADETLIEQL VKKEGDISKLAEHLDLKIDTRLSKSHEQYLCLKKLEKTMQRSDDDKWLDLYESLPSFV HESQAMQRFYPYGDRKQYANLSNEEWSDVSYDSFQDCLTCDMRHRCGLTLSRDYYRKS TDLIICSHDFYMEHVWTEESRKREGQLPLLPDHSAVVFDEGHLLEFAAQKALTYRVKQ STLELFLERLLQNDIREEFAELIEDALLANDEFFYVLSEESKEVAGSHRLEIKNDHRV KKAADELCRLLDKIGEALVFESEMYTIDQYELSVVEEYVEQMAYSLSLYQKDAISWLE KKEAESTFVVMPRTVAEVLGEKVFSKKIPYIFSSATLSEGGSFDYIADSLGIHDYLSL TVDSPYDYDEQMSINLYAKTDMDAEQKTAETIETIKRYKGRTLVLFPSFEELNEFKEL SAAWELPYPIFFEGDEEISSLVEKFQEEEETVLCSVHLWEGLDIPGDALKNVTIWSLP FPPHDPVFTAKRNGAKKDPFEEVDLPYMLLRVRQGIGRLIRSNQDSGSIHIYAGGENE RIIDEVKKVLPVEPHMM*" gene complement(2193086..2195011) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" promotor_-10 complement(2195042..2195061) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2195046) /Source="Nicolas_upshifts" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" S_feature complement(2195048..2195112) /Source="Nicolas_S_feature" /locus_tag="new_2329450_2329514_c" /HighExp="S3, S4, S8, S7, LoTm, S5, S6, BT, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S837" promotor_-35 complement(2195076..2195080) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2195113..2195304) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390098.1" /db_xref="EnsemblGenomes-Gn:BSU22160" /db_xref="EnsemblGenomes-Tr:CAB14133" /db_xref="SubtiList:BG11456" /db_xref="UniProtKB/Swiss-Prot:P50841" /translation="MLNSEHFNLIQRALDATANELKELGTDSSPSVISHAQTDLEKAV EHIYSTDHPFLSSHVINRK*" gene complement(2195113..2195304) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" promotor_-10 complement(2195323..2195341) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2195332) /Source="Nicolas_upshifts" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" S_feature complement(2195334..2195639) /Source="Nicolas_S_feature" /locus_tag="new_2329736_2330041_c" /HighExp="Cold, G135, G180, C30, G150, Oxctl, Paraq, H2O2, LBGstat, LPh" /AntisenseName="ypzG" /AntisenseCor="-0.39420155633160697" /AntisenseRegPval="-10.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S838" promotor_-35 complement(2195357..2195362) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2195371..2195377 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2195392..2195403 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2195401 /Source="Nicolas_upshifts" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" CDS 2195468..2195620 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097754.1" /db_xref="EnsemblGenomes-Gn:BSU22169" /db_xref="EnsemblGenomes-Tr:CAX52653" /db_xref="InterPro:IPR025413" /db_xref="UniProtKB/Swiss-Prot:C0H444" /translation="MSYRNRLDQHSELFHHNWTRPKRSKSQVNGHTEMSQTNIILRSN AKAHRW*" gene 2195468..2195620 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" downshifts 2195630 /Source="Nicolas_upshifts" /id="D1162" /incds=0 /nref=35 /ntot=65 /MaxReadThrough="1.2837" /MaxDrop="7.64655" /score="-9.36260071" /energy="-16.3" /TU="NA" /idTUdmin="U1738" /TUdmin=0 /isTUend="TRUE" CDS complement(2195673..2196830) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" /EC_number="2.1.1.264" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22210896, 22362734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="m(7)G2069 methylase of 23S rRNA" /protein_id="NP_390099.1" /db_xref="EnsemblGenomes-Gn:BSU22170" /db_xref="EnsemblGenomes-Tr:CAB14134" /db_xref="GOA:P50840" /db_xref="InterPro:IPR000241" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11455" /db_xref="UniProtKB/Swiss-Prot:P50840" /translation="MKKYTLIATAPMGIEAVVAKEVRDLGYECKVDNGKVIFEGDALA ICRANLWLRTADRIKVQVASFKAKTFDELFEKTKAINWRSFIPENGKFPVIGKSVKST LASVPDCQRIVKKAIVEKLKLQSGKANDWIEETGAEYKVEISLLKDQALITLDSSGTG LHKRGYRVDQGGAPIKETLAAALVQLTNWTPDRPFVDPFCGSGTIAIEAALIGQNIAP GFNRDFVSEDWEWIGKDLWNKARLEVEEKANYDQPLTIFASDIDHRMVQIAKENAEEA GLGDLIQFKQMQVKDFTTNLEFGVIVGNPPYGERLGEKKAVEQMYKEMGQAFEPLDTW SVYMLTSNENFEEAYGRKATKKRKLFNGFIKTDYYQYWSKVRPQRKKTENA*" gene complement(2195673..2196830) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" downshifts complement(2195684) /Source="Nicolas_upshifts" /id="D1163" /incds=0 /nref=86 /ntot=240 /MaxReadThrough="4.31441" /MaxDrop="4.58268" /score="14.6684819" /energy="-6.2" /TU="U1739" /idTUdmin="U1740" /TUdmin=0 /isTUend="TRUE" misc_RNA complement(2196918..2197318) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" /product="RNA component of ribonuclease P (RNase P) (catalytic subunit, ribozyme)" /experiment="publication(s) with functional evidences, PMID:1699929, 16980484, 17919279, 22448220" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1699929, 16980484, 17919279, 22448220; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2196918..2197318) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" downshifts complement(2196928) /Source="Nicolas_upshifts" /id="D1164" /incds=0 /nref=200 /ntot=276 /MaxReadThrough="6.17541" /MaxDrop="7.4677" /score="0.20729905" /energy="-10.4" /TU="U1739,U1740" /idTUdmin="U1742" /TUdmin=406 /isTUend="FALSE" promotor_-10 complement(2197315..2197334) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2197333) /Source="Nicolas_upshifts" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" promotor_-35 complement(2197349..2197355) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2197377..2197673) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:18363795, 18776011, 19429628, 25845974, 27257764" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18363795, 18776011, 19429628, 25845974, 27257764; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell division protein" /protein_id="NP_390100.1" /db_xref="EnsemblGenomes-Gn:BSU22180" /db_xref="EnsemblGenomes-Tr:CAB14135" /db_xref="GOA:P0CI74" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR011229" /db_xref="InterPro:IPR019933" /db_xref="PDB:4UG3" /db_xref="PDB:5AN5" /db_xref="SubtiList:BG11454" /db_xref="UniProtKB/Swiss-Prot:P0CI74" /translation="MLADKVKLSAKEILEKEFKTGVRGYKQEDVDKFLDMIIKDYETF HQEIEELQQENLQLKKQLEEASKKQPVQSNTTNFDILKRLSNLEKHVFGSKLYD*" gene complement(2197377..2197673) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" promotor_-10 complement(2197698..2197717) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(2197708) /Source="Nicolas_upshifts" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" promotor_-35 complement(2197731..2197738) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(2197751..2198380) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390101.2" /db_xref="EnsemblGenomes-Gn:BSU22190" /db_xref="EnsemblGenomes-Tr:CAB14136" /db_xref="InterPro:IPR010697" /db_xref="PDB:2NX2" /db_xref="SubtiList:BG11453" /db_xref="UniProtKB/Swiss-Prot:P50838" /translation="MENVQLDGVNNAAQQMGPTGAPFFKAGEMMKVLAITGYKPFELG IFKQDDKALYYIKKAIKNRLIAFLDEGLEWILISGQLGVELWAAEAAYDLQEEYPDLK VAVITPFYEQEKNWKEPNKEQYEAVLAQADYEASLTHRPYESPLQFKQKNQFFIDKSD GLLLLYDPEKEGSPKYMLGTAEKRREQDGYPIYFITMDDLRVTVEEDSY*" gene complement(2197751..2198380) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" downshifts complement(2198346) /Source="Nicolas_upshifts" /id="D1165" /incds=0 /nref=37 /ntot=160 /MaxReadThrough="5.74028" /MaxDrop="8.12374" /score="7.18626302" /energy="-9.8" /TU="U1741,U1742" /idTUdmin="U1744" /TUdmin=0 /isTUend="TRUE" CDS complement(2198382..2198609) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2821284, 10075739, 10400595, 1518043, 1691789, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2821284, 10075739, 10400595, 1518043, 1691789, 19933362; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner)" /protein_id="NP_390102.1" /db_xref="EnsemblGenomes-Gn:BSU22200" /db_xref="EnsemblGenomes-Tr:CAB14137" /db_xref="GOA:P07791" /db_xref="InterPro:IPR020108" /db_xref="SubtiList:BG10493" /db_xref="UniProtKB/Swiss-Prot:P07791" /translation="MHHCRPHMMAPIVHPTHCCEHHTFSKTIVPHIHPQHTTNVNHQH FQHVHYFPHTFSNVDPATHQHFQAGKPCCDY*" gene complement(2198382..2198609) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" promotor_-10 complement(2198637..2198656) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-10" upshifts complement(2198652) /Source="Nicolas_upshifts" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" S_feature complement(2198654..2198808) /Source="Nicolas_S_feature" /locus_tag="new_2333056_2333210_c" /HighExp="LBGexp, dia15, Paraq, H2O2, Heat, G135, UNK1, Lbexp, BMM, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.808141" /TUshortSig="SigA, Sig-, SigA, SigA" /TUshortPSig="1, 0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S839" promotor_-35 complement(2198670..2198678) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-35" CDS complement(2198693..2198821) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513975.1" /translation="MTLVIFKGRVGMYKGVFYLFFVVVFLIAFVFSNFKDSLIAHF*" gene complement(2198693..2198821) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" upshifts complement(2198808) /Source="Nicolas_upshifts" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" S_feature complement(2198810..2198921) /Source="Nicolas_S_feature" /locus_tag="new_2333212_2333323_c" /HighExp="Sw, M40t90, Etha, Salt, M40t45, H2O2, S8, S6, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S840" promotor_-10 complement(2198811..2198830) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" promotor_-35 complement(2198846..2198850) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(2198922..2200163) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23249255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding enzyme" /protein_id="NP_390103.1" /db_xref="EnsemblGenomes-Gn:BSU22210" /db_xref="EnsemblGenomes-Tr:CAB14138" /db_xref="GOA:P50837" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11452" /db_xref="UniProtKB/Swiss-Prot:P50837" /translation="MSLKGKLQRMKKHMALDEGEQKIEAGKQENHFDDIPFLEEWEAF GMKPFIFEDEYCLIREVEYPLSHRHGLYSFSELEEVITLWNQSGLSHTLSAKGYNKNN LFFFDTETTGLGGGAGNTIFLLGHARVYEDRVTVKQHLLPKPGNEVALYQSFLSEVDI TSLVTYNGKAFDWPQVKTRHTLIRDRLPKLPEFGHFDLLHGARRLWKHKMDRVSLGTV EKEELGIRRLEDTPGYLAPMLYFHFIKAQEPDLLKGVLHHNEMDVLSLISLYIHMSKK ILSESHAPKEHSEAYAMAKWFMAHKETDQAIKQLERLIEKSFEDQDSARLDLSLLYKK QNRLEEAVPLWEKLSRSQNQKCRYAAVIELAKYFEHKKKEFGKALQVAEQSLSDAACL SEKETEKLHVRIARLKRKYSS*" gene complement(2198922..2200163) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" promotor_-10 complement(2199877..2199895) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-10" upshifts complement(2199886) /Source="Nicolas_upshifts" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" promotor_-35 complement(2199910..2199917) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-35" CDS complement(2200179..2202428) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" /EC_number="3.6.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_390104.1" /db_xref="EnsemblGenomes-Gn:BSU22220" /db_xref="EnsemblGenomes-Tr:CAB14139" /db_xref="GOA:P50830" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018973" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11451" /db_xref="UniProtKB/Swiss-Prot:P50830" /translation="MKKKSLTELISDLKGNENVVNWHEIEPREAKTRPMPESIDERIK AALSKRGIDELYTHQYSAFQYVQKGESIVTVTPTASGKTLCYNLPVLQSIAQDETNRA LYLFPTKALAQDQKSELNEIIDEMGIDIKSFTYDGDTSPAIRQKVRKAGHIVITNPDM LHSAILPHHTKWVSLFENLKYIVIDELHTYRGVFGSHVANVIRRLKRICRFYGSDPVF ICTSATIANPKELGEQLTGKPMRLVDDNGAPSGRKHFVFYNPPIVNKPLNIRRSATAE VNELAKEFLKNKVQTIVFARSRVRVEIILSHIQELVKKEIGTKSIRGYRGGYLPKERR EIERGLREGDILGVVSTNALELGVDIGQLQVCVMTGYPGSVASAWQQAGRAGRRHGES LIIMVANSTPIDQYIVRHPEYFFNRSPESARINPENLIILVDHLKCAAYELPFRADEE FGAMEVSDILEYLQEEAVLHRNGERYHWASESFPASNISLRSASQENVVIVDQSDIAN VRIIGEMDRFSAMTLLHDEAIYLHEGVQYQVEKLDWDHKKAYVRKVDVEYYTDANLAV QLKVLEIDKTKEKSRTSLHYGDVTVNALPTIFKKIKMTTFENIGSGPIHLPEEELHTS AAWLEIKTADEDIGEKTLEQLLLGISNVLQHIVPVYIMCDRNDVHVVSQIKAAHTGLP TIFLYDHYPGGIGLAEEVFKRFSDINEAAKQLITHCPCHDGCPSCIGTEIEGIKAKER ILQLLDQMS*" gene complement(2200179..2202428) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" promotor_-10 complement(2202444..2202463) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(2202460) /Source="Nicolas_upshifts" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" promotor_-35 complement(2202477..2202483) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(2202531..2203037) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10627040, 28731580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase system enzyme IIA component" /protein_id="NP_390105.1" /db_xref="EnsemblGenomes-Gn:BSU22230" /db_xref="EnsemblGenomes-Tr:CAB14140" /db_xref="GOA:P50829" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG11450" /db_xref="UniProtKB/Swiss-Prot:P50829" /translation="MLKKLFGMGKIQEKVTEEVIYSPADGTVMDLSDVPDPVFSQKMM GEGIAVEPSSGEIVSPAEGEVIQIFHTKHAVGIRTRSGIELLIHVGLETVNMNGEGFT AHIKEGDKVKVGDPLITCDLELIKEKASSTVIPIVIMNGEAVGSMVSAGEKAARKGES KLFTIKAK*" gene complement(2202531..2203037) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" downshifts complement(2202554) /Source="Nicolas_upshifts" /id="D1166" /incds=0 /nref=88 /ntot=236 /MaxReadThrough="4.55156" /MaxDrop="6.1724" /score="32.5355561" /energy="-10.2" /TU="U1745" /idTUdmin="U1747" /TUdmin=808 /isTUend="FALSE" promotor_-10 complement(2203081..2203100) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(2203098) /Source="Nicolas_upshifts" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" promotor_-35 complement(2203114..2203121) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" promotor_-35 2203119..2203128 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2203142..2203161 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2203154 /Source="Nicolas_upshifts" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" CDS 2203175..2203594 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_390106.1" /db_xref="EnsemblGenomes-Gn:BSU22240" /db_xref="EnsemblGenomes-Tr:CAB14141" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11449" /db_xref="UniProtKB/Swiss-Prot:P50836" /translation="MEFHDDKKNELQKKEEIITEAIDTLFQSSAFGNLINGFQNLINS SLKDVQTTIHVRERDTGLYIDITIPATFRDGEIVVDVKSRYLHVTLQEKQKHQNEATF TSMTRTVQLPYEVRQEDMETSWNEQTMTLFFPKNKHE*" gene 2203175..2203594 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" S_feature 2203595..2203745 /Source="Nicolas_S_feature" /locus_tag="new_2337997_2338147" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, nit" /AntisenseName="yppG" /AntisenseCor="0.95679380325708796" /AntisenseRegPval="-144.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S841" CDS complement(2203615..2203992) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein; methionine-glutamine-rich protein" /protein_id="NP_390107.1" /db_xref="EnsemblGenomes-Gn:BSU22250" /db_xref="EnsemblGenomes-Tr:CAB14142" /db_xref="InterPro:IPR025555" /db_xref="SubtiList:BG11448" /db_xref="UniProtKB/Swiss-Prot:P50835" /translation="MNGSSRSYPRQMGYYYPQHMQGYYQQAAPGYLEQQLPQQHYGQQ DYYQPYAPIQPMPMQPPVFSNPYPIPRPNQQQPSQFQSIMSQFKKANGQFDFNKMMDT TGQVMSAMNQVGSLIKGFTSFFK*" gene complement(2203615..2203992) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" downshifts complement(2203648) /Source="Nicolas_upshifts" /id="D1167" /incds=0 /nref=10 /ntot=43 /MaxReadThrough="3.01854" /MaxDrop="4.7006" /score="0.85617333" /energy="-12.8" /TU="U1747" /idTUdmin="U1747" /TUdmin="-286" /isTUend="FALSE" S_feature 2203990..2204135 /Source="Nicolas_S_feature" /locus_tag="new_2338392_2338537" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, C30" /AntisenseName="yppG" /AntisenseCor="0.96504903995490698" /AntisenseRegPval="-156.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S842" promotor_-10 complement(2204022..2204040) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2204041) /Source="Nicolas_upshifts" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" promotor_-35 complement(2204054..2204063) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2204136..2204155 /Source="Nicolas_upshift_promotors" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2204137 /Source="Nicolas_upshifts" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" CDS 2204180..2204368 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390108.1" /db_xref="EnsemblGenomes-Gn:BSU22260" /db_xref="EnsemblGenomes-Tr:CAB14143" /db_xref="InterPro:IPR025553" /db_xref="SubtiList:BG11447" /db_xref="UniProtKB/Swiss-Prot:P50834" /translation="MNVSYLSKRFAEMKKYETDCMNKLMDFAKFLYIQGHLSITEFRN SMKVLEANGAESPAYEMN*" gene 2204180..2204368 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" downshifts 2204384 /Source="Nicolas_upshifts" /id="D1168" /incds=0 /nref=112 /ntot=242 /MaxReadThrough="3.3677" /MaxDrop="5.69944" /score="0.283992322" /energy="-8.5" /TU="U1748" /idTUdmin="U1748" /TUdmin="-200" /isTUend="FALSE" CDS complement(2204407..2204778) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390109.1" /db_xref="EnsemblGenomes-Gn:BSU22270" /db_xref="EnsemblGenomes-Tr:CAB14144" /db_xref="InterPro:IPR014913" /db_xref="InterPro:IPR023351" /db_xref="PDB:2HFI" /db_xref="PDB:2IM8" /db_xref="SubtiList:BG11446" /db_xref="UniProtKB/Swiss-Prot:P50833" /translation="MLSQTLLEMTEQMIEVAEKGADRYQEGKNSNHSYDFFETIKPAV EENDELAARWAEGALELIKVRRPKYVHKEQIEAVKDNFLELVLQSYVHHIHKKRFKDI TESVLYTLHAVKDEIAREDSR*" gene complement(2204407..2204778) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" downshifts complement(2204440) /Source="Nicolas_upshifts" /id="D1169" /incds=0 /nref=158 /ntot=245 /MaxReadThrough="1.04225" /MaxDrop="5.78413" /score="-2.77698308" /energy="-10.3" /TU="NA" /idTUdmin="U1749" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2204790..2204809) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2204803) /Source="Nicolas_upshifts" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" promotor_-35 complement(2204822..2204827) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2204824..2205069) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15687200; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390110.1" /db_xref="EnsemblGenomes-Gn:BSU22280" /db_xref="EnsemblGenomes-Tr:CAB14145" /db_xref="InterPro:IPR020252" /db_xref="SubtiList:BG11445" /db_xref="UniProtKB/Swiss-Prot:P50832" /translation="MSGYVCKTDILRMLSDIEDELTRAEQSLNHSVNALEAEMRETEN DRLSVLEEEIIDLHICINELYQSPEHRYAFEKVYRIG*" gene complement(2204824..2205069) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" promotor_-10 complement(2205095..2205113) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2205100) /Source="Nicolas_upshifts" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" promotor_-35 complement(2205125..2205133) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2205219..2205225 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2205240..2205251 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2205247 /Source="Nicolas_upshifts" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" CDS 2205268..2205372 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054585.1" /db_xref="EnsemblGenomes-Gn:BSU22290" /db_xref="EnsemblGenomes-Tr:CAE01459" /db_xref="GOA:Q7WY65" /db_xref="SubtiList:BG14177" /db_xref="UniProtKB/Swiss-Prot:Q7WY65" /translation="MKTRPKKAGQQKKTESKAIDSLDKKLGGPNRPST*" gene 2205268..2205372 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" downshifts 2205354 /Source="Nicolas_upshifts" /id="D1170" /incds=0 /nref=31 /ntot=49 /MaxReadThrough="1.6498" /MaxDrop="6.01285" /score="0.283992322" /energy="-8.5" /TU="NA" /idTUdmin="U1751" /TUdmin=0 /isTUend="TRUE" CDS complement(2205397..2206359) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390111.1" /db_xref="EnsemblGenomes-Gn:BSU22300" /db_xref="EnsemblGenomes-Tr:CAB14146" /db_xref="InterPro:IPR019658" /db_xref="SubtiList:BG10952" /db_xref="UniProtKB/Swiss-Prot:P39791" /translation="MNVQEQQAIRKLLSRIERQTKMKNADNISRTNAYKAFYDRHPEI KWSLLASFVSRNAGWSMTDLKGSLFQLGLRERQQKWFFLAYERANWLIFSDAYPQLLL YHWSKRVGKPLFHLLHVFGVSQFMSEEWTRFWHERNTERLMYALIINEQNTIQTPIIQ NPSFKKNVFDTIPFYLSDWFHFNTVIFPSSNGFFYGISVKRFSKAEERIRLGKQLSQL LFKPELFSSFYHFLHTVPHTGSRFDMEKMIGITKRTSPMLRTCYPELIHSLDGTKTDW FHGKIKKTFFRREELPKQIELTDWYLHKKRQLHALFAVEQWLKK*" gene complement(2205397..2206359) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" promotor_-35 2205527..2205536 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2205548..2205563 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2205548 /Source="Nicolas_upshifts" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" S_feature 2205552..2205887 /Source="Nicolas_S_feature" /locus_tag="new_2339954_2340289" /HighExp="T1.0H, T0.30H, T1.30H, H2O2, Paraq, LBGstat, T2.0H, T-0.40H, Salt, T2.30H" /AntisenseName="yppC" /AntisenseCor="-0.27690969451148201" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S843" promotor_-35 2205858..2205862 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2205878..2205897 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2205889..2206399 /Source="Nicolas_S_feature" /locus_tag="new_2340291_2340801" /HighExp="LBGstat, T1.0H, T1.30H, H2O2, T0.30H, Paraq, T2.0H, C30, G135, G180" /AntisenseName="yppC" /AntisenseCor="-0.312791370178301" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S844" upshifts 2205889 /Source="Nicolas_upshifts" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" S_feature complement(2206360..2206816) /Source="Nicolas_S_feature" /locus_tag="new_2340762_2341218_c" /HighExp="S8, S6, S7, S5, C30, G135, S4, BT, G180, Fru" /AntisenseName="recU" /AntisenseCor="-0.34780203121991599" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S845" CDS 2206400..2207020 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction resolvase" /protein_id="NP_390112.1" /db_xref="EnsemblGenomes-Gn:BSU22310" /db_xref="EnsemblGenomes-Tr:CAB14147" /db_xref="GOA:P39792" /db_xref="InterPro:IPR004612" /db_xref="InterPro:IPR011335" /db_xref="PDB:1RZN" /db_xref="PDB:1ZP7" /db_xref="PDB:5FDK" /db_xref="SubtiList:BG10953" /db_xref="UniProtKB/Swiss-Prot:P39792" /translation="MIRYPNGKTFQPKHSVSSQNSQKRAPSYSNRGMTLEDDLNETNK YYLTNQIAVIHKKPTPVQIVNVHYPKRSAAVIKEAYFKQSSTTDYNGIYKGRYIDFEA KETKNKTSFPLQNFHDHQIEHMKQVKAQDGICFVIISAFDQVYFLEADKLFYFWDRKE KNGRKSIRKDELEETAYPISLGYAPRIDYISIIEQLYFSPSSGAKG*" gene 2206400..2207020 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" promotor_-10 complement(2206805..2206816) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2206816) /Source="Nicolas_upshifts" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" promotor_-35 complement(2206831..2206837) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2207042..2209786 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" /EC_number="2.4.1.129" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan glycosyltransferase (penicillin-binding proteins 1A and 1B)" /protein_id="NP_390113.1" /db_xref="EnsemblGenomes-Gn:BSU22320" /db_xref="EnsemblGenomes-Tr:CAB14148" /db_xref="GOA:P39793" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR003961" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036116" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10954" /db_xref="UniProtKB/Swiss-Prot:P39793" /translation="MSDQFNSREARRKANSKSSPSPKKGKKRKKGGLFKKTLFTLLIL FVLGVVGGAVTFAVMVSDAPSLDESKLKTPYSSTIYDKNGKEIAEVGAEKRTYVSIDE IPDVVKEAFIATEDARFYEHHGIDPVRIGGALVANFKDGFGAEGGSTITQQVVKNSLL SHQKTLKRKVQEVWLSIQLERNYSKDEILEMYLNRIYFSPRAYGIGKAAEEFFGVTDL SKLTVEQAATLAGMPQSPTAYNPVKNPDKAEKRRNIVLSLMKKQGFISDSQYNKAKKV AVKDEGVVSQKEYEKASTNKYSAFVEEVMKEIDEKSDVDPSADGLKIYTTLDTKAQDK LDELMDGDTVGFTEGMQGGVTLLDTKNGEVRAIGAGRNQPVGGFNYATQTKAQPGSTI KPILDYGPVIENKKWSTYEQIDDSAYTYSNGKPIRDWDRKYLGPISMRYALAQSRNIP ALKAFQAVGKDTAVDFANGLGLGLTKDNVTEAYSIGGFGGNDGVSPLTMAGAYSAFGN NGTYNEPHFVKSIEFNDGTKLDLTPKSKSAMSDYTAFMITDMLKTAVKTGTGQLAQVP GVEVAGKTGTTNFDDNEVKRYNIASGGARDSWFVGYTPQYTAAVWTGMGENEAGKKSL SAEEQKVAKRIFAQLIADVDDGSGSFEKPDSVVEATVEKGSNPAKLAGPNTPSDKKLT EYFVKGTAPSTVSKTYEKEEKEETAKLSGLNVKYDKDNQSLTLSWNYDGDATFAVKQS VDGGSYSEIQNSSAKEAVISGVQPGSVYKFEVTAVSDDGKSTASTSYEVPKAEDDEDK KDQQQTDDEKQDDEKTQDDTQTDDSQKDDGQTDQDQTDDSTNDQDKKQDNTNTNPSDN NNQDQSNDNDNDNSNNQDTSDGDSNSGKNDSTGSDTNKNKTDTSNKTQTNSSSIEKTN *" gene 2207042..2209786 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" downshifts complement(2209456) /Source="Nicolas_upshifts" /id="D1171" /incds=1 /nref=1 /ntot=77 /MaxReadThrough="1.95969" /MaxDrop="2.87717" /score="24.9960782" /energy="-11.3" /TU="NA" /idTUdmin="U1755" /TUdmin=418 /isTUend="FALSE" downshifts 2209772 /Source="Nicolas_upshifts" /id="D1172" /incds=0 /nref=243 /ntot=302 /MaxReadThrough="1.61976" /MaxDrop="7.42523" /score="24.2831363" /energy="-14.6" /TU="U1753" /idTUdmin="U1752" /TUdmin="-4" /isTUend="TRUE" CDS complement(2209862..2210356) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390114.1" /db_xref="EnsemblGenomes-Gn:BSU22330" /db_xref="EnsemblGenomes-Tr:CAB14149" /db_xref="SubtiList:BG10955" /db_xref="UniProtKB/Swiss-Prot:P39789" /translation="MTQAKEVLASYEQYLRSLGQKSSSDMKKTLQTNPVYFDFCTELQ GDLPWEDSGKYVPLLFEVWDDIKASLLPVFQTRKSRCDQNEMLKGIVCLLASLHWTAG EPVKSLDWQELREKSYPAKPINWAERVEFILLKPTQYHCFIQLDELITEMKKHFYKYH AMNR*" gene complement(2209862..2210356) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" downshifts complement(2209875) /Source="Nicolas_upshifts" /id="D1173" /incds=0 /nref=116 /ntot=222 /MaxReadThrough="2.50883" /MaxDrop="5.43593" /score="29.5358766" /energy="-11.6" /TU="NA" /idTUdmin="U1755" /TUdmin="-1" /isTUend="TRUE" CDS complement(2210353..2211012) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" /EC_number="4.2.99.18" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9808040, 11160880, 12682299, 21954439, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9808040, 11160880, 12682299, 21954439, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease III, apurinic apyrimidic DNA lyase" /protein_id="NP_390115.1" /db_xref="EnsemblGenomes-Gn:BSU22340" /db_xref="EnsemblGenomes-Tr:CAB14150" /db_xref="GOA:P39788" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR004035" /db_xref="InterPro:IPR004036" /db_xref="InterPro:IPR005759" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG10956" /db_xref="UniProtKB/Swiss-Prot:P39788" /translation="MLNLKQIEFCLDKIGDMFPHAECELVHSNPFELVVAVALSAQCT DALVNRVTKTLFQKYKRPEDYLAVPLEELQQDIKSIGLYRNKAKNIQKLSKMIIEDYG GEVPRDRDELVKLPGVGRKTANVVVSVAFGVPAIAVDTHVERVSKRLGICRWKDSVLE VEKTLMRKVPKEDWSVTHHRLIFFGRYHCKAQSPRCAECPLLSLCREGQKRDKKGLVK R*" gene complement(2210353..2211012) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" CDS complement(2211031..2211729) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" /function="16.9: Replicate" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-remodelling primosomal protein" /protein_id="NP_390116.1" /db_xref="EnsemblGenomes-Gn:BSU22350" /db_xref="EnsemblGenomes-Tr:CAB14151" /db_xref="GOA:P39787" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="PDB:2V79" /db_xref="SubtiList:BG10957" /db_xref="UniProtKB/Swiss-Prot:P39787" /translation="MKKQQFIDMQEQGTSTIPNLLLTHYKQLGLNETELILLLKIKMH LEKGSYFPTPNQLQEGMSISVEECTNRLRMFIQKGFLFIEECEDQNGIKFEKYSLQPL WGKLYEYIQLAQNQTQERKAEGEQKSLYTIFEEEFARPLSPLECETLAIWQDQDQHDA QLIKHALKEAVLSGKLSFRYIDRILFEWKKNGLKTVEQAKIHSQKFRRVQAKQNEPQK EYKRQVPFYNWLEQ*" gene complement(2211031..2211729) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" S_feature complement(2211730..2211821) /Source="Nicolas_S_feature" /locus_tag="new_2346132_2346223_c" /HighExp="LoTm, G180, Cold, G135, LBGstat, G150, C30, Etha, Oxctl, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S846" CDS complement(2211822..2213114) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" /EC_number="6.1.1.22" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparaginyl-tRNA synthetase" /protein_id="NP_390117.1" /db_xref="EnsemblGenomes-Gn:BSU22360" /db_xref="EnsemblGenomes-Tr:CAB14152" /db_xref="GOA:P39772" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004522" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10958" /db_xref="UniProtKB/Swiss-Prot:P39772" /translation="MKTTINQVYKHVGEEVTIGAWVANKRSSGKIAFLQLRDGTGFIQ GVVVKAEVEESIFQTAKSVTQETSLYIKGIVKEDERSPLGYELAVTDIEVIHEATDYP ITPKEHGTEFLMDHRHLWLRSKRQHAIMKIRNEIIRATYEFFNNEGFVKVDPPILTGS APEGTTELFATKYFDEDAYLSQSGQLYMEAAAMALGKVFSFGPTFRAEKSKTKRHLIE FWMIEPEMAFVEFEENLQVQENYVSFIVQSVLKNCKIELNTLGRDTSKLEQIKAPFPR ITYDEAIEFLKEKGFDDIEWGDDFGAPHETAIAEHYDKPVFITRYPTSLKPFYMQPAS DREDVVLCADLIAPEGYGEIIGGSERIHDMELLESRLKEHGLDSDAYKWYAELRKYGS VPHSGFGLGLERTVAWISGAPHVRETIPFPRLLNRLYP*" gene complement(2211822..2213114) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" S_feature complement(2213115..2213176) /Source="Nicolas_S_feature" /locus_tag="new_2347517_2347578_c" /HighExp="LBGexp, dia0, Lbexp, G150, G180, LPh, C30, Oxctl, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S847" promotor_-10 complement(2213176..2213195) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2213176) /Source="Nicolas_upshifts" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" promotor_-35 complement(2213210..2213217) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2213258..2214439) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" /EC_number="2.6.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:418816, 12670965, 22740702" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 418816, 12670965, 22740702; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anabolic oxaloacetate / glutamate aminotransferase" /protein_id="NP_390118.1" /db_xref="EnsemblGenomes-Gn:BSU22370" /db_xref="EnsemblGenomes-Tr:CAB14153" /db_xref="GOA:P53001" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11513" /db_xref="UniProtKB/Swiss-Prot:P53001" /translation="MKLAKRVSALTPSTTLAITAKAKELKAAGHDVIGLGAGEPDFNT PQHIIDAAVRSMNEGHTKYTPSGGLAELKNSIAEKFKRDQNIEYKPSQIIVCTGAKHA LYTLFQVILDEEDEVIIPTPYWVSYPEQVKLAGGKPVYVEGLEENHFKISPEQLKNAI TEKTKAIVINSPSNPTGVMYTEEELSALGEVCLEHDILIVSDEIYEKLTYGGKKHVSI AQLSDRLKEQTVIINGVSKSHSMTGWRIGYAAGSEDIIKAMTNLASHSTSNPTSIAQY GAIAAYNGPSEPLEEMREAFEHRLNTIYAKLIEIPGFSCVKPEGAFYLFPNAKEAAQS CGFKDVDEFVKALLEEEKVAIVPGSGFGSPENVRLSYATSLDLLEEAIERIKRFVEKH S*" gene complement(2213258..2214439) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" downshifts complement(2213262) /Source="Nicolas_upshifts" /id="D1174" /incds=0 /nref=48 /ntot=196 /MaxReadThrough="6.37268" /MaxDrop="4.0831" /score="5.04709675" /energy="-9.3" /TU="U1756,U1758,U1760,U1761,U1762" /idTUdmin="U1760" /TUdmin="-66" /isTUend="FALSE" CDS complement(2214462..2214947) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" /experiment="publication(s) with functional evidences, PMID:25954268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25954268; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="suppressor of tetracyclin sensitivity of an ezrAmutant" /protein_id="NP_390119.1" /db_xref="EnsemblGenomes-Gn:BSU22380" /db_xref="EnsemblGenomes-Tr:CAB14154" /db_xref="GOA:P54396" /db_xref="InterPro:IPR025711" /db_xref="PDB:2GU3" /db_xref="SubtiList:BG11502" /db_xref="UniProtKB/Swiss-Prot:P54396" /translation="MRKKALIFTVIFGIIFLAVLLVSASIYKSAMAQKEEGHEAAAAE AKKETDLAHVDQVETFVGKEKYYVVKGTDKKGTALYVWVPADKKAKILSKEAKEGISE DKAAKIIKDEGLVSKQKEVHLAREGNVLLWEVTYLDKEGQYSLSYVDFTTGKILKNIT P*" gene complement(2214462..2214947) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" promotor_-10 complement(2214895..2214914) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2214912) /Source="Nicolas_upshifts" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" promotor_-35 complement(2214927..2214934) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2214956..2215126) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390120.1" /db_xref="EnsemblGenomes-Gn:BSU22390" /db_xref="EnsemblGenomes-Tr:CAB14155" /db_xref="InterPro:IPR012190" /db_xref="SubtiList:BG11501" /db_xref="UniProtKB/Swiss-Prot:P54395" /translation="MESKIEILSTINVEHSDDLYKIVDTLNRTLKRDNLMFGLALDEE NKNQAVFTIYRT*" gene complement(2214956..2215126) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" S_feature complement(2215127..2215198) /Source="Nicolas_S_feature" /locus_tag="new_2349529_2349600_c" /HighExp="H2O2, T0.30H, T0.0H, dia15, T-0.40H, T-1.10H, G135, T1.0H, G180, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.136042" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.85, 1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S848" promotor_-35 2215160..2215166 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2215181..2215200) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2215181..2215192 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2215188..2215262 /Source="Nicolas_S_feature" /locus_tag="new_2349590_2349664" /HighExp="S8, S6, S5, S7, nit, BT, G/S, Pyr, C30, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S849" upshifts 2215188 /Source="Nicolas_upshifts" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(2215198) /Source="Nicolas_upshifts" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" S_feature complement(2215200..2215268) /Source="Nicolas_S_feature" /locus_tag="new_2349602_2349670_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, Salt, H2O2, T-1.10H, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S850" promotor_-35 complement(2215216..2215222) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2215232 /Source="Nicolas_upshifts" /id="D1175" /incds=0 /nref=8 /ntot=26 /MaxReadThrough="0.48859" /MaxDrop="6.02806" /score="18.4569945" /energy="-8.4" /TU="NA" /idTUdmin="U1757" /TUdmin=0 /isTUend="TRUE" CDS complement(2215269..2218064) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8385320, 12060778, 17416902, 21546913, 22166102, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385320, 12060778, 17416902, 21546913, 22166102, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="damage inducible ATP-dependent 3'->5' nuclease" /protein_id="NP_390121.1" /db_xref="EnsemblGenomes-Gn:BSU22400" /db_xref="EnsemblGenomes-Tr:CAB14156" /db_xref="GOA:P54394" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006310" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11515" /db_xref="UniProtKB/Swiss-Prot:P54394" /translation="MNKQRFVVIDVETTGNSPKKGDKIIQIAAVVIENGQITERFSKY INPNKSIPAFIEQLTGISNQMVENEQPFEAVAEEVFQLLDGAYFVAHNIHFDLGFVKY ELHKAGFQLPDCEVLDTVELSRIVFPGFEGYKLTELSEELQLRHDQPHRADSDAEVTG LIFLEILEKLRQLPYPTLKQLRRLSQHFISDLTHLLDMFINENRHTEIPGYTRFSSFS VREPEAIDVRINEDENFSFEIESWEAGNEKALSELMPGYEKRDGQMMMMREVADAFAN REHALIEAPPGIGKTIGYLIPAALFAKKSKKPVIISTYSTLLQQQILTKDLPIVQDLF PFPVTAAILKGQSHYLCLYKFEQVLHEEDDNYDAVLTKAQLLVWLTETNTGDVAELNL PSGGKLLWDRLAYDDDSYKRSRSEHVIGFYERAKQIAMRSDLVITNHSLLLTDEGSHK KRLPESGTFIIDEAHHFERAASEHLGKRATYIELHTKLSRIGTLKEQGLLKKMRQLFQ RNSLPVDSFFELEEWLQHVQAESDAFFSSVHSFVKRRKPKEDLNRLVFKVNKESQDKS WSILTDGAERLCSMLTHLQQLFEAQSSLMEKHLKGMKSKTVFLADEYQRSMKGLQHYC QTLQKLFFGSDDDEAVWIEIDAKGAKNAVAIYAQPLEPGELLADQFFARKNSVVLTSA TLTVEGSFQFMIERLGLSDFFPRTMRIESPFSYDERMQVMIPKEMKSIQDTGQPEFIQ DTARYIELMAKEKQPKILVLFTSHDMLKKVHQELKHNMSASGIQLLAQGITGGSPGKL MKTFKTSNQAILLGTNHFWEGVDFPGDELTTVMIVRLPFRSPDHPLHAAKCELARKKG KNPFQTVSLPEAVLTFRQGIGRLLRSAGDKGTIIILDRRIKTAGYGRLFLDALPTTSV SEMTDSELEAYVAGEKE*" gene complement(2215269..2218064) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" promotor_-35 2215737..2215741 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2215738 /Source="Nicolas_upshifts" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2215743..2215747 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2216394..2216409) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(2216408) /Source="Nicolas_upshifts" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" promotor_-35 complement(2216422..2216431) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" S_feature complement(2218065..2218189) /Source="Nicolas_S_feature" /locus_tag="new_2352467_2352591_c" /HighExp="dia15, Diami, H2O2, Heat, LBGstat, C30, G180, G135, Oxctl, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S851" CDS complement(2218190..2218573) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" /EC_number="4.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9169598, 12600205, 15033515, 26762040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9169598, 12600205, 15033515, 26762040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate 1-decarboxylase" /protein_id="NP_390122.1" /db_xref="EnsemblGenomes-Gn:BSU22410" /db_xref="EnsemblGenomes-Tr:CAB14157" /db_xref="GOA:P52999" /db_xref="InterPro:IPR003190" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG11493" /db_xref="UniProtKB/Swiss-Prot:P52999" /translation="MYRTMMSGKLHRATVTEANLNYVGSITIDEDLIDAVGMLPNEKV QIVNNNNGARLETYIIPGKRGSGVICLNGAAARLVQEGDKVIIISYKMMSDQEAASHE PKVAVLNDQNKIEQMLGNEPARTIL*" gene complement(2218190..2218573) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" CDS complement(2218575..2219435) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" /EC_number="6.3.2.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17175524, 7037743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate synthetase" /protein_id="NP_390123.1" /db_xref="EnsemblGenomes-Gn:BSU22420" /db_xref="EnsemblGenomes-Tr:CAB14158" /db_xref="GOA:P52998" /db_xref="InterPro:IPR003721" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11520" /db_xref="UniProtKB/Swiss-Prot:P52998" /translation="MRQITDISQLKEAIKQYHSEGKSIGFVPTMGFLHEGHLTLADKA RQENDAVIMSIFVNPAQFGPNEDFEAYPRDIERDAALAENAGVDILFTPDAHDMYPGE KNVTIHVERRTDVLCGRSREGHFDGVAIVLTKLFNLVKPTRAYFGLKDAQQVAVVDGL ISDFFMDIELVPVDTVREEDGLAKSSRNVYLTAEERKEAPKLYRALQTSAELVQAGER DPEAVIKAAKDIIETTSGTIDYVELYSYPELEPVNEIAGKMILAVAVAFSKARLIDNI IIDIREMERI*" gene complement(2218575..2219435) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" CDS complement(2219437..2220270) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" /EC_number="2.1.2.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 8096212; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ketopantoate hydroxymethyltransferase" /protein_id="NP_390124.1" /db_xref="EnsemblGenomes-Gn:BSU22430" /db_xref="EnsemblGenomes-Tr:CAB14159" /db_xref="GOA:P52996" /db_xref="InterPro:IPR003700" /db_xref="InterPro:IPR015813" /db_xref="SubtiList:BG11519" /db_xref="UniProtKB/Swiss-Prot:P52996" /translation="MKTKLDFLKMKESEEPIVMLTAYDYPAAKLAEQAGVDMILVGDS LGMVVLGLDSTVGVTVADMIHHTKAVKRGAPNTFIVTDMPFMSYHLSKEDTLKNAAAI VQESGADALKLEGGEGVFESIRALTLGGIPVVSHLGLTPQSVGVLGGYKVQGKDEQSA KKLIEDSIKCEEAGAMMLVLECVPAELTAKIAETLSIPVIGIGAGVKADGQVLVYHDI IGHGVERTPKFVKQYTRIDETIETAISGYVQDVRHRAFPEQKHSFQMNQTVLDGLYGG K*" gene complement(2219437..2220270) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" S_feature complement(2220271..2220478) /Source="Nicolas_S_feature" /locus_tag="new_2354673_2354880_c" /HighExp="LBGstat, dia15, Diami, H2O2, MG 15, Heat, Oxctl, MG 25, MG 10, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S852" promotor_-10 complement(2220473..2220492) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2220478) /Source="Nicolas_upshifts" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" promotor_-35 complement(2220509..2220513) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2220516..2221493) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" /EC_number="6.3.4.15" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12368242, 15459338, 28466579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 15459338, 28466579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin acetyl-CoA-carboxylase ligase and biotin regulon repressor (BirA-biotinoyl-5'-AMP)" /protein_id="NP_390125.1" /db_xref="EnsemblGenomes-Gn:BSU22440" /db_xref="EnsemblGenomes-Tr:CAB14160" /db_xref="GOA:P0CI75" /db_xref="InterPro:IPR003142" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004408" /db_xref="InterPro:IPR004409" /db_xref="InterPro:IPR008988" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR030855" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11206" /db_xref="UniProtKB/Swiss-Prot:P0CI75" /translation="MRSTLRKDLIELFSQAGNEFISGQKISDALGCSRTAVWKHIEEL RKEGYEVEAVRRKGYRLIKKPGKLSESEIRFGLKTEVMGQHLIYHDVLSSTQKTAHEL ANNNAPEGTLVVADKQTAGRGRMSRVWHSQEGNGVWMSLILRPDIPLQKTPQLTLLAA VAVVQGIEEAAGIQTDIKWPNDILINGKKTVGILTEMQAEEDRVRSVIIGIGINVNQQ PNDFPDELKDIATSLSQAAGEKIDRAGVIQHILLCFEKRYRDYMTHGFTPIKLLWESY ALGIGTNMRARTLNGTFYGKALGIDDEGVLLLETNEGIKKIYSADIELG*" gene complement(2220516..2221493) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" CDS complement(2221478..2222671) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" /EC_number="2.7.7.72" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9829937, 16109934, 20360175, 22940585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829937, 16109934, 20360175, 22940585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA nucleotidyltransferase" /protein_id="NP_390126.1" /db_xref="EnsemblGenomes-Gn:BSU22450" /db_xref="EnsemblGenomes-Tr:CAB14161" /db_xref="GOA:P42977" /db_xref="InterPro:IPR002646" /db_xref="InterPro:IPR023068" /db_xref="InterPro:IPR032810" /db_xref="InterPro:IPR032828" /db_xref="SubtiList:BG11208" /db_xref="UniProtKB/Swiss-Prot:P42977" /translation="MEKVFIKALPVLRILIEAGHQAYFVGGAVRDSYMKRTIGDVDIA TDAAPDQVERLFQRTVDVGKEHGTIIVLWEDETYEVTTFRTESDYVDFRRPSEVQFIS SLEEDLKRRDLTINAMAMTADGKVLDYFGGKKDIDQKVIRTVGKPEDRFQEDALRMLR AVRFMSQLGFTLSPETEEAIAKEKSLLSHVSVERKTIEFEKLLQGRASRQALQTLIQT RLYEELPGFYHKRENLISTSEFPFFSLTSREELWAALLINLGIVLKDAPLFLKAWKLP GKVIKEAIHIADTFGQSLDAMTMYRAGKKALLSAAKISQLRQNEKLDEKKLKDIQYAY QNLPIKSLKDLDITGKDLLALRNRPAGKWVSEELQWIEQAVVTGKLSNQKKHIEEWLK TCGQH*" gene complement(2221478..2222671) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" CDS complement(2222676..2223809) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" /EC_number="2.4.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751541, 20308541, 22569254, 27454321, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751541, 20308541, 22569254, 27454321, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate synthase;malate glycosyltransferase for bacillithiol synthesis" /protein_id="NP_390127.1" /db_xref="EnsemblGenomes-Gn:BSU22460" /db_xref="EnsemblGenomes-Tr:CAB14162" /db_xref="GOA:P42982" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR023881" /db_xref="InterPro:IPR028098" /db_xref="PDB:5D00" /db_xref="PDB:5D01" /db_xref="SubtiList:BG11213" /db_xref="UniProtKB/Swiss-Prot:P42982" /translation="MRKLKIGITCYPSVGGSGIIATELGKQLAEKGHEIHFITSSIPF RLNTYHPNIHFHEVEVNQYAVFKYPPYDLTLASKIAEVAERENLDIIHAHYALPHAVC AYLAKQMLKRNIGIVTTLHGTDITVLGYDPSLKDLIRFAIESSDRVTAVSSALAAETY DLIKPEKKIETIYNFIDERVYLKKNTAAIKEKHGILPDEKVVIHVSNFRKVKRVQDVI RVFRNIAGKTKAKLLLVGDGPEKSTACELIRKYGLEDQVLMLGNQDRVEDLYSISDLK LLLSEKESFGLVLLEAMACGVPCIGTNIGGIPEVIKNNVSGFLVDVGDVTAATARAMS ILEDEQLSNRFTKAAIEMLENEFSSKKIVSQYEQIYADLAEPE*" gene complement(2222676..2223809) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" CDS complement(2223806..2224516) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" /EC_number="3.5.1.-" /function="4.10: Glutathione and analogs" /experiment="publication(s) with functional evidences, PMID:11004195, 20308541, 23894131, 28117687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004195, 20308541, 23894131, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate deacetylase 1; malate N-acetylglucosamine N-acetyl hydrolase" /protein_id="NP_390128.2" /db_xref="EnsemblGenomes-Gn:BSU22470" /db_xref="EnsemblGenomes-Tr:CAB14163" /db_xref="GOA:P42981" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023842" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG11212" /db_xref="UniProtKB/Swiss-Prot:P42981" /translation="MYNADVLAFGAHSDDVEIGMGGTIAKFVKQEKKVMICDLTEAEL SSNGTVSLRKEEAAEAARILGADKRIQLTLPDRGLIMSDQAIRSIVTVIRICRPKAVF MPYKKDRHPDHGNAAALVEEAIFSAGIHKYKDEKSLPAHKVSKVYYYMINGFHQPDFV IDISDTIEAKKQSLNAYKSQFIPSKDSVSTPLTNGYIEIVEAREKLYGKEAGVEYAEG FFSKRMLMLDHDVLGGEQ*" gene complement(2223806..2224516) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" CDS complement(2224509..2224922) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" /EC_number="4.2.3.3" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxal synthase" /protein_id="NP_390129.1" /db_xref="EnsemblGenomes-Gn:BSU22480" /db_xref="EnsemblGenomes-Tr:CAB14164" /db_xref="GOA:P42980" /db_xref="InterPro:IPR004363" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR018148" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG11211" /db_xref="UniProtKB/Swiss-Prot:P42980" /translation="MKIALIAHDKKKQDMVQFTTAYRDILKNHDLYATGTTGLKIHEA TGLQIERFQSGPLGGDQQIGALIAANALDLVIFLRDPLTAQPHEPDVSALIRLCDVYS IPLATNMGTAEILVRTLDEGVFEFRDLLRGEEPNV*" gene complement(2224509..2224922) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" CDS complement(2224938..2225741) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" /EC_number="1.17.1.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6422596, 9398235, 12682299, 20503968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(4S)-4-hydroxy-2,3,4, 5-tetrahydro-(2S)-dipicolinic acid (HTPA) dehydratase reductase" /protein_id="NP_390130.1" /db_xref="EnsemblGenomes-Gn:BSU22490" /db_xref="EnsemblGenomes-Tr:CAB14165" /db_xref="GOA:P42976" /db_xref="InterPro:IPR000846" /db_xref="InterPro:IPR022663" /db_xref="InterPro:IPR022664" /db_xref="InterPro:IPR023940" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11207" /db_xref="UniProtKB/Swiss-Prot:P42976" /translation="MSNETIKLVIAGPRGRMGQEAVKLAERTPHFDLVGAIDHTYDQQ KLSDVMPVESDAFIYTDIHACFTETQPDVLIDLTTPEIGKVHTKIALEHGVRPVVGTT GFSEADLKELTSLTEEKGIGAIIAPNFALGAILMMKFSKMAANYFEDVEIIELHHDQK LDAPSGTALKTAEMISEVRKEKQQGHPDEKEILPGARGAEQNGIRLHSVRLPGLIAHQ EVMFGMDGQTLQIRHDSYNRASFMSGVKLSVEQVMKIDQLVYGLENIID*" gene complement(2224938..2225741) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" CDS complement(2225753..2226088) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16390452, 20529853, 20944217, 21733847, 24339782, 26920050, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidized nucleotide pyrophosphohydrolase" /protein_id="NP_390131.1" /db_xref="EnsemblGenomes-Gn:BSU22500" /db_xref="EnsemblGenomes-Tr:CAB14166" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR012359" /db_xref="PDB:2GTA" /db_xref="SubtiList:BG11210" /db_xref="UniProtKB/Swiss-Prot:P42979" /translation="MSDKTMKDIQAEVDRYIGQFKEGYFSPLAMMARLTEELGELARE VNHRYGEKPKKATEDDKSMEEEIGDVLFVLVCLANSLDISLEEAHDRVMHKFNTRDKD RWTRKEEGK*" gene complement(2225753..2226088) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" promotor_-10 complement(2226108..2226127) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(2226118) /Source="Nicolas_upshifts" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" promotor_-35 complement(2226141..2226148) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" promotor_-35 2226157..2226164 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2226173..2226192) /Source="Nicolas_upshift_promotors" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 2226178..2226197 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2226184 /Source="Nicolas_upshifts" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" upshifts complement(2226192) /Source="Nicolas_upshifts" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" CDS 2226228..2227100 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390132.2" /db_xref="EnsemblGenomes-Gn:BSU22510" /db_xref="EnsemblGenomes-Tr:CAB14167" /db_xref="GOA:P42978" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11209" /db_xref="UniProtKB/Swiss-Prot:P42978" /translation="MLGEIRLKNIFFILIGAAIFSFGLVHFNMQNNLAEGGFTGITLL LYALFHISPSISNLVLNIPIFFIGWRLLGRTMFVYTLVGTVALSLFLSIFQRYEIHMP LQHDLALAALFAGVFIGAGLGIIFKFGGTTGGVDIIARLVNKYFGIPMGRTMFAFDAC VIILSLLTYLSYKEAMYTLVAVFVAARLIDFIQEGGYAAKGATIISSKNDLIQKKILE EMERGVTILKGQGSYTKEDIDVLYCVVPKNELVMLKSVINSIDPHAFVAVSDVHDVLG EGFTLDENKNPLPR*" gene 2226228..2227100 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" CDS complement(2227142..2227936) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="sporulation septum-associated protein" /protein_id="NP_390133.1" /db_xref="EnsemblGenomes-Gn:BSU22520" /db_xref="EnsemblGenomes-Tr:CAB14168" /db_xref="GOA:P54393" /db_xref="InterPro:IPR014231" /db_xref="SubtiList:BG11500" /db_xref="UniProtKB/Swiss-Prot:P54393" /translation="MKRKLTICLLIALIFYNGNAKAAERGSLEELNDLSDTVFQMTRQ AKYEEALQVLEYFEKTLKSAEKKQQDPMLTGAQIRQITLGYNDMVRSLKQADTSDTQK LRAAAQFRMLMDAVDNRSDPLWGSLEKPIMEAFTELKRDVQKNGSTSFHEKWNEFISL YDLIYPSLTIDVSEDQLETVGKHIDVIEQEEFQQMTESTKLERLSLLQHDLKNVFDRV EEDDADPSLLWVIITTGSIIITALTYVGYRKYKAEKNKLKKRDYPK*" gene complement(2227142..2227936) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" downshifts complement(2227167) /Source="Nicolas_upshifts" /id="D1176" /incds=0 /nref=4 /ntot=106 /MaxReadThrough="1.96946" /MaxDrop="3.51024" /score="34.9661402" /energy="-11.3" /TU="NA" /idTUdmin="U1765" /TUdmin=198 /isTUend="FALSE" S_feature complement(2227937..2228004) /Source="Nicolas_S_feature" /locus_tag="new_2362339_2362406_c" /HighExp="LBGstat, C30, S0, LoTm, G180, G135, G150, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S853" CDS complement(2228005..2228562) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390134.1" /db_xref="EnsemblGenomes-Gn:BSU22530" /db_xref="EnsemblGenomes-Tr:CAB14169" /db_xref="GOA:P54392" /db_xref="InterPro:IPR009845" /db_xref="SubtiList:BG11499" /db_xref="UniProtKB/Swiss-Prot:P54392" /translation="MLILVLAINFLGTVYGYYWYLPQLLETPARFLIFVPDSPTATFF FLFVLLAFLMKRNAPLLEALALVTLVKYGLWAVAMNFLVLAVTGDLPWEGYMLIASHF AMAVQGVLYSPYFRFSFWHLAIAAVWTLHNDVIDYLFDMMPQYSMLSDYMTEIGYGTF WLSIFSIALAYFLVVSKKQTKLELM*" gene complement(2228005..2228562) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" S_feature complement(2228563..2228642) /Source="Nicolas_S_feature" /locus_tag="new_2362965_2363044_c" /HighExp="C30, UNK1, G135, BMM, G150, G180, Oxctl, LoTm, Paraq, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S854" downshifts complement(2228687) /Source="Nicolas_upshifts" /id="D1177" /incds=0 /nref=131 /ntot=215 /MaxReadThrough="3.97061" /MaxDrop="6.41485" /score="13.3880841" /energy="-8" /TU="U1765" /idTUdmin="U1767" /TUdmin="-2" /isTUend="TRUE" CDS complement(2228709..2229476) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome cc subunit)" /protein_id="NP_390135.1" /db_xref="EnsemblGenomes-Gn:BSU22540" /db_xref="EnsemblGenomes-Tr:CAB14170" /db_xref="GOA:P46913" /db_xref="InterPro:IPR005798" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012049" /db_xref="InterPro:IPR027387" /db_xref="InterPro:IPR036150" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG11327" /db_xref="UniProtKB/Swiss-Prot:P46913" /translation="MHRGKGMKFVGDSRIPAEKKPNIPKDYSEYPGKTEAFWPNFLLK EWMVGAVFLIGFLVLTIVHQPPLERMADPTDTGYIPLPDWYFLFLYQLLKYEYAAGSF TVVGAMIMPGLAFGALLLAPFLDRGTERRPWKRPVAVGMMLLAISAAVFLTWQSVATH DWAKAEEQGKITKEADIDTNAEGYKVFKEQGCISCHGDNLQGGAAGPSLVDSGLKPDE IKKIAVEGKGKMPAGVFKGNDKQLEELAKFISETTAK*" gene complement(2228709..2229476) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" CDS complement(2229511..2230185) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 15849754, 16850406; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome b subunit)" /protein_id="NP_390136.1" /db_xref="EnsemblGenomes-Gn:BSU22550" /db_xref="EnsemblGenomes-Tr:CAB14171" /db_xref="GOA:P46912" /db_xref="InterPro:IPR005797" /db_xref="InterPro:IPR016174" /db_xref="InterPro:IPR023530" /db_xref="InterPro:IPR027387" /db_xref="SubtiList:BG11326" /db_xref="UniProtKB/Swiss-Prot:P46912" /translation="MLNKIYDWVDERLDITPMWRDIADHEVPEHVNPAHHFSAFVYCF GGLTFFVTVIQVLSGMFLTMYYVPDIKNAWESVYYLQNEVAFGQIVRGMHHWGASLVI VMMFLHTLRVFFQGAYKKPRELNWIVGVLIFFVMLGLGFTGYLLPWDMKALFATKVGL QIAEATPLIGTQVKTLLAGHPDIVGAQTLTRFFAIHVFFLPAALFGLMAAHFIMIRKQ GISGPL*" gene complement(2229511..2230185) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" CDS complement(2230187..2230690) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" /EC_number="1.10.2.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 24652282, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (iron-sulfur subunit)" /protein_id="NP_390137.1" /db_xref="EnsemblGenomes-Gn:BSU22560" /db_xref="EnsemblGenomes-Tr:CAB14172" /db_xref="GOA:P46911" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR014349" /db_xref="InterPro:IPR014909" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11325" /db_xref="UniProtKB/Swiss-Prot:P46911" /translation="MGGKHDISRRQFLNYTLTGVGGFMAASMLMPMVRFALDPVLKST GKQDMVQVVSVDELTKEPQRFDFKINQVDAWYESEESRSAWVFKNGDEIVALSPICKH LGCTVNWNSDPKNPNKFFCPCHYGLYEKDGTNVPGTPPLAPLDHYEQEVKDGFLYLGK AKPKGEG*" gene complement(2230187..2230690) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" downshifts 2230699 /Source="Nicolas_upshifts" /id="D1178" /incds=0 /nref=1 /ntot=80 /MaxReadThrough="1.24169" /MaxDrop="3.42621" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=3608 /isTUend="FALSE" promotor_-10 complement(2230754..2230773) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2230754) /Source="Nicolas_upshifts" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" promotor_-35 complement(2230788..2230795) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2230833..2231279) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15743949" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390138.1" /db_xref="EnsemblGenomes-Gn:BSU22570" /db_xref="EnsemblGenomes-Tr:CAB14173" /db_xref="InterPro:IPR019615" /db_xref="SubtiList:BG11498" /db_xref="UniProtKB/Swiss-Prot:P54391" /translation="MRWRITDAKDYLQAKDYIDTAVIPLINIRVNNHFKMAAEKGEFT QLLSEELERQLKGRVYLLPPYTYVDRNEITVQGLKDLREELITEFPHVVLLTSDESWR AEDALGKMIVTSSVPLEHLNDSLKRKILDERTAEILNVLLQLWSTL*" gene complement(2230833..2231279) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" downshifts 2231282 /Source="Nicolas_upshifts" /id="D1179" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="0.94679" /MaxDrop="2.794" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=4191 /isTUend="FALSE" CDS complement(2231334..2231873) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16847875" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390139.1" /db_xref="EnsemblGenomes-Gn:BSU22580" /db_xref="EnsemblGenomes-Tr:CAB14174" /db_xref="InterPro:IPR011188" /db_xref="InterPro:IPR014957" /db_xref="InterPro:IPR014963" /db_xref="SubtiList:BG11497" /db_xref="UniProtKB/Swiss-Prot:P54390" /translation="MQTPVSVNEKKDFIRWFLNHYQLKRRECVWILNYLMSHDSLMEK VHFVEQAEFCPRGIIMSTHCVEEVPFRFYKENVMTTDAEKSFHDIRLNKQQDLFIQLN FRSAYSSPEYAAVLESNPHIPKNLFENKKDQGLAEQILEHAISTFQREKLLKDIDDAL DRHDKEAFEQLSRQLNQLT*" gene complement(2231334..2231873) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" downshifts complement(2231347) /Source="Nicolas_upshifts" /id="D1180" /incds=0 /nref=84 /ntot=250 /MaxReadThrough="5.68366" /MaxDrop="5.48142" /score="16.8021869" /energy="-11.2" /TU="U1766,U1767" /idTUdmin="U1768" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2231906..2231924) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(2231917) /Source="Nicolas_upshifts" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" promotor_-35 complement(2231936..2231944) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" CDS complement(2231945..2233216) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390140.1" /db_xref="EnsemblGenomes-Gn:BSU22590" /db_xref="EnsemblGenomes-Tr:CAB14175" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11496" /db_xref="UniProtKB/Swiss-Prot:P54389" /translation="MNTLIQEAIKLVEAGETEKGLNTLSKAEKQLHDEDKAIAAQLYY EWGDVEKAISLISDLHDLYPNETELTNFYAELLIDIDEEEKALAVLETIPETDPSYPE SLLLMADLYQMQGLFEVSEQKLFQAKSILDNEPVIDFALGELYFAQGAYAKAVQYFKT TAEEQSEIGGVNVHQRLAESLSASGEFEDAIPWYEKAVDENPDPNTIFGYGFTALQAG LVKTAIKQLSDLKELDPSYTSLYMPLSKSYEAEGMYEEALKTAKEGIRYDEYNKELFL YAAKMALKIGKSEEGKKLLQEALALDPGFVEALHTLLAVYHKEEDYDQIIDLIQEVRS YGEEDPKYNWYLASAYTELEQYEEAKQSFEAAYLHYREDRDFLYEYASFLLEEGLQKE ALPLLKKVLEMDGANEELEETILRIEDEFSR*" gene complement(2231945..2233216) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" S_feature complement(2233217..2233284) /Source="Nicolas_S_feature" /locus_tag="new_2367619_2367686_c" /HighExp="dia15, Diami, dia5, Etha, H2O2, T1.30H, LPhT, T0.30H, T3.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF, SigA" /TUshortPSig="0.999, 0.999, 0.999, 1" /TUlongSig="Sig-, Sig-, SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.047, 0.994, 0.999, 1, 0.999, 1, 0.998" /label="S855" promotor_-10 complement(2233281..2233300) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2233284) /Source="Nicolas_upshifts" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" promotor_-35 complement(2233314..2233321) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2233351..2233370) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(2233357) /Source="Nicolas_upshifts" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" S_feature complement(2233359..2233503) /Source="Nicolas_S_feature" /locus_tag="new_2367761_2367905_c" /HighExp="S3, LoTm, M9-stat, S4, Etha, S5, T5.0H, BT, B36, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.047, 0.994" /TUlongSig="Sig-, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.999, 1, 0.999, 1, 0.998" /label="S856" promotor_-35 complement(2233381..2233388) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" promotor_-10 complement(2233485..2233503) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(2233503) /Source="Nicolas_upshifts" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" promotor_-35 complement(2233519..2233524) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(2233552..2234838) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" /EC_number="2.5.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3106153, 22938038, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvoylshikimate-3-phosphate synthase)" /protein_id="NP_390141.1" /db_xref="EnsemblGenomes-Gn:BSU22600" /db_xref="EnsemblGenomes-Tr:CAB14176" /db_xref="GOA:P20691" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR006264" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR023193" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10294" /db_xref="UniProtKB/Swiss-Prot:P20691" /translation="MKRDKVQTLHGEIHIPGDKSISHRSVMFGALAAGTTTVKNFLPG ADCLSTIDCFRKMGVHIEQSSSDVVIHGKGIDALKEPESLLDVGNSGTTIRLMLGILA GRPFYSAVAGDESIAKRPMKRVTEPLKKMGAKIDGRAGGEFTPLSVSGASLKGIDYVS PVASAQIKSAVLLAGLQAEGTTTVTEPHKSRDHTERMLSAFGVKLSEDQTSVSIAGGQ KLTAADIFVPGDISSAAFFLAAGAMVPNSRIVLKNVGLNPTRTGIIDVLQNMGAKLEI KPSADSGAEPYGDLIIETSSLKAVEIGGDIIPRLIDEIPIIALLATQAEGTTVIKDAA ELKVKETNRIDTVVSELRKLGAEIEPTADGMKVYGKQTLKGGAAVSSHGDHRIGMMLG IASCITEEPIEIEHTDAIHVSYPTFFEHLNKLSKKS*" gene complement(2233552..2234838) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" downshifts complement(2233575) /Source="Nicolas_upshifts" /id="D1181" /incds=0 /nref=68 /ntot=212 /MaxReadThrough="3.64462" /MaxDrop="4.25336" /score="16.8021869" /energy="-11.2" /TU="U1770,U1772,U1773" /idTUdmin="U1775" /TUdmin="-6" /isTUend="TRUE" CDS complement(2234849..2235964) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" /EC_number="1.3.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106153, 3121591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106153, 3121591; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydrogenase" /protein_id="NP_390142.1" /db_xref="EnsemblGenomes-Gn:BSU22610" /db_xref="EnsemblGenomes-Tr:CAB14177" /db_xref="GOA:P20692" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003099" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10293" /db_xref="UniProtKB/Swiss-Prot:P20692" /translation="MNQMKDTILLAGLGLIGGSIALAIKKNHPGKRIIGIDISDEQAV AALKLGVIDDRADSFISGVKEAATVIIATPVEQTLVMLEELAHSGIEHELLITDVGST KQKVVDYADQVLPSRYQFVGGHPMAGSHKSGVAAAKEFLFENAFYILTPGQKTDKQAV EQLKNLLKGTNAHFVEMSPEEHDGVTSVISHFPHIVAASLVHQTHHSENLYPLVKRFA AGGFRDITRIASSSPAMWRDILLHNKDKILDRFDEWIREIDKIRTYVEQEDAENLFRY FKTAKDYRDGLPLRQKGAIPAFYDLYVDVPDHPGVISEITAILAAERISITNIRIIET REDINGILRISFQSDDDRKRAEQCIEARAEYETFYAD*" gene complement(2234849..2235964) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" CDS complement(2236013..2237095) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" /EC_number="2.6.1.5" /EC_number="2.6.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4431, 418816, 824269, 11518529, 15102328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4431, 418816, 824269, 11518529, 15102328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol-phosphate aminotransferase; tyrosine/phenylalanine aminotransferase (promiscuous)" /protein_id="NP_390143.2" /db_xref="EnsemblGenomes-Gn:BSU22620" /db_xref="EnsemblGenomes-Tr:CAB14178" /db_xref="GOA:P17731" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR005861" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10292" /db_xref="UniProtKB/Swiss-Prot:P17731" /translation="MRIKEHLKQLKPYQPGKPIEAVKSEYGLDKVVKLASNENPYGCS EAAKEALHHEIQQLALYPDGYSAALRTRLSKHLNVSETSLIFGNGSDEIIQIICRAFL NDKTNTVTAAPTFPQYKHNAVIEGAEVREIALRPDGSHDLDAMLEAIDEQTQVVWICS PNNPTGTYTSEGELLAFLERVPSRVLVVLDEAYYEYVTAEDYPETVPLLSKYSNLMIL RTFSKAYGLAALRVGYGIADENLIRQIEPAREPFNTSRLGQAAAIAALDDQAFIASCV EQNNAGLQQYYDFAKTHGLKCYPSQTNFVLIDFKRPADELFQALLEKGYIVRSGNALG FPTSLRITIGTKEQNEEILAILAEIL*" gene complement(2236013..2237095) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" CDS complement(2237106..2237909) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (alpha subunit)" /protein_id="NP_390144.1" /db_xref="EnsemblGenomes-Gn:BSU22630" /db_xref="EnsemblGenomes-Tr:CAB14179" /db_xref="GOA:P07601" /db_xref="InterPro:IPR002028" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018204" /db_xref="SubtiList:BG10291" /db_xref="UniProtKB/Swiss-Prot:P07601" /translation="MFKLDLQPSEKLFIPFITAGDPVPEVSIELAKSLQKAGATALEL GVAYSDPLADGPVIQRASKRALDQGMNIVKAIELGGEMKKNGVNIPIILFTYYNPVLQ LNKEYFFALLRENHIDGLLVPDLPLEESNSLQEECKSHEVTYISLVAPTSESRLKTII EQAEGFVYCVSSLGVTGVRNEFNSSVYPFIRTVKNLSTVPVAVGFGISNREQVIKMNE ISDGVVVGSALVRKIEELKDRLISAETRNQALQEFEDYAMAFSGLYSLK*" gene complement(2237106..2237909) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" promotor_-10 complement(2237594..2237613) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(2237611) /Source="Nicolas_upshifts" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" promotor_-35 complement(2237625..2237632) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(2237902..2239104) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (beta subunit)" /protein_id="NP_390145.2" /db_xref="EnsemblGenomes-Gn:BSU22640" /db_xref="EnsemblGenomes-Tr:CAB14180" /db_xref="GOA:P07600" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR006653" /db_xref="InterPro:IPR006654" /db_xref="InterPro:IPR023026" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10290" /db_xref="UniProtKB/Swiss-Prot:P07600" /translation="MYPYPNEIGRYGDFGGKFVPETLMQPLDEIQTAFKQIKDDPAFR EEYYKLLKDYSGRPTALTYADRVTEYLGGAKIYLKREDLNHTGSHKINNALGQALLAK KMGKTKIIAETGAGQHGVAAATVAAKFGFSCTVFMGEEDVARQSLNVFRMKLLGAEVV PVTSGNGTLKDATNEAIRYWVQHCEDHFYMIGSVVGPHPYPQVVREFQKMIGEEAKDQ LKRIEGTMPDKVVACVGGGSNAMGMFQAFLNEDVELIGAEAAGKGIDTPLHAATISKG TVGVIHGSLTYLIQDEFGQIIEPYSISAGLDYPGIGPEHAYLHKSGRVTYDSITDEEA VDALKLLSEKEGILPAIESAHALAKAFKLAKGMDRGQLILVCLSGRGDKDVNTLMNVL EEEVKAHV*" gene complement(2237902..2239104) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" CDS complement(2239085..2239732) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" /EC_number="5.3.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylanthranilate isomerase" /protein_id="NP_390146.3" /db_xref="EnsemblGenomes-Gn:BSU22650" /db_xref="EnsemblGenomes-Tr:CAB14181" /db_xref="GOA:P20167" /db_xref="InterPro:IPR001240" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10289" /db_xref="UniProtKB/Swiss-Prot:P20167" /translation="MKKPALKYCGIRSLKDLQLAAESQADYLGFIFAESKRKVSPEDV KKWLNQVRVEKQVAGVFVNESIETMSRIAKSLKLDVIQLHGDEKPADAAALRKLTGCE IWKALHHQDNTTQEIARFKDNVDGFVIDSSVKGSRGGTGVAFSWECVPEYQQAAIGKR CFIAGGVNPDSITRLLKWQPEGIDLASGIEKNGQKDQNLMRLLEERMNRYVSISE*" gene complement(2239085..2239732) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" downshifts complement(2239179) /Source="Nicolas_upshifts" /id="D1182" /incds=1 /nref=30 /ntot=83 /MaxReadThrough="8.17917" /MaxDrop="5.75867" /score="2.96963632" /energy="-11.9" /TU="U1771,U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=616 /isTUend="FALSE" misc_feature complement(2239355..2239358) /Source="Nicolas_upshift_promotors" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2239355) /Source="Nicolas_upshifts" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" downshifts complement(2239575) /Source="Nicolas_upshifts" /id="D1183" /incds=1 /nref=1 /ntot=84 /MaxReadThrough="8.55417" /MaxDrop="3.4408" /score="2.96963632" /energy="-11.9" /TU="U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=220 /isTUend="FALSE" CDS complement(2239737..2240486) /gene="trpC" /locus_tag="BSU_22660" /old_locus_tag="BSU22660" /EC_number="4.1.1.48" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10627030, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10627030, 10714985, 12963367, 17114058; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="indole-3-glycerol phosphate synthase" /db_xref="GOA:P03964" /db_xref="InterPro:IPR001468" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013798" /db_xref="PSEUDO:CAB14182.3" /db_xref="SubtiList:BG11038" /db_xref="UniProtKB/Swiss-Prot:P03964" /translation="MLEKIIKQKKEEVKTLVLPVEQPFEKRSFKEALASPNRFIGLIA EVKKASPSKGLIKEDFVPVQIAKDYEAAKADAISVLTDTPFFQGENSYLSDVKRAVSI PVLRKDFIDSLQVEESRRIGADAILLIGEVLDPLHLHELYLEAGEKGMDVLVEVHDAS TLEQILKVFTPDILGVNNRNLKTFETSVKQTEQIASLVPKESLLVSESGIGSLEHLTF VNEHGARAVLIGESLMRQTSQRKAIHALFRE*" gene complement(2239737..2240486) /gene="trpC" /locus_tag="BSU_22660" /old_locus_tag="BSU22660" /pseudo misc_feature complement(2239770..2239772) /Source="Nicolas_upshift_promotors" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2239773) /Source="Nicolas_upshifts" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" CDS complement(2240479..2241495) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" /EC_number="2.4.2.18" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 17114058; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="anthranilate phosphoribosyltransferase" /protein_id="NP_390148.2" /db_xref="EnsemblGenomes-Gn:BSU22670" /db_xref="EnsemblGenomes-Tr:CAB14183" /db_xref="GOA:P03947" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR005940" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="SubtiList:BG10288" /db_xref="UniProtKB/Swiss-Prot:P03947" /translation="MNRFLQLCVDGKTLTAGEAETLMNMMMAAEMTPSEMGGILSILA HRGETPEELAGFVKAMRAHALTVDGLPDIVDTCGTGGDGISTFNISTASAIVASAAGA KIAKHGNRSVSSKSGSADVLEELEVSIQTTPEKVKSSIETNNMGFLFAPLYHSSMKHV AGTRKELGFRTVFNLLGPLSNPLQAKRQVIGVYSVEKAGLMASALETFQPKHVMFVSS RDGLDELSITAPTDVIELKDGERREYTVSPEDFGFTNGRLEDLQVQSPKESAYLIQNI FENKSSSSALSITAFNAGAAIYTAGITASLKEGTELALETITSGGAAAQLERLKQKEE EIYA*" gene complement(2240479..2241495) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" CDS complement(2241467..2243014) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anthranilate synthase" /protein_id="NP_390149.1" /db_xref="EnsemblGenomes-Gn:BSU22680" /db_xref="EnsemblGenomes-Tr:CAB14184" /db_xref="GOA:P03963" /db_xref="InterPro:IPR005256" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10287" /db_xref="UniProtKB/Swiss-Prot:P03963" /translation="MNFQSNISAFLEDSLSHHTIPIVETFTVDTLTPIQMIEKLDREI TYLLESKDDTSTWSRYSFIGLNPFLTIKEEQGRFSAADQDSKSLYTGNELKEVLNWMN TTYKIKTPELGIPFVGGAVGYLSYDMIPLIEPSVPSHTKETDMEKCMLFVCRTLIAYD HETKNVHFIQYARLTGEETKNEKMDVFHQNHLELQNLIEKMMDQKNIKELFLSADSYK TPSFETVSSNYEKSAFMADVEKIKSYIKAGDIFQGVLSQKFEVPIKADAFELYRVLRI VNPSPYMYYMKLLDREIVGSSPERLIHVQDGHLEIHPIAGTRKRGADKAEDERLKVEL MKDEKEKAEHYMLVDLARNDIGRVAEYGSVSVPEFTKIVSFSHVMHIISVVTGRLKKG VHPVDALMSAFPAGTLTGAPKIRAMQLLQELEPTPRETYGGCIAYIGFDGNIDSCITI RTMSVKNGVASIQAGAGIVADSVPEAEYEESCNKAGALLKTIHIAEDMFHSKEDKADE QISTIVR*" gene complement(2241467..2243014) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" S_feature complement(2243093..2243224) /Source="Nicolas_S_feature" /locus_tag="new_2377495_2377626_c" /HighExp="Etha, S1, GM 25, GM 15, HiTm, Glu, MG-0.1, GM 60, M9-exp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.994, 0.647, 0.999, 1, 0.996" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.998" /label="S857" downshifts complement(2243136) /Source="Nicolas_upshifts" /id="D1184" /incds=0 /nref=61 /ntot=157 /MaxReadThrough="7.41666" /MaxDrop="5.25158" /score="2.96963632" /energy="-11.9" /TU="U1773,U1774,U1775,U1776" /idTUdmin="U1777" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2243215..2243234) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-10" upshifts complement(2243224) /Source="Nicolas_upshifts" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" CDS complement(2243230..2243613) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate mutase" /protein_id="NP_390150.1" /db_xref="EnsemblGenomes-Gn:BSU22690" /db_xref="EnsemblGenomes-Tr:CAB14185" /db_xref="GOA:P19080" /db_xref="InterPro:IPR008243" /db_xref="InterPro:IPR035959" /db_xref="PDB:1COM" /db_xref="PDB:1DBF" /db_xref="PDB:1FNJ" /db_xref="PDB:1FNK" /db_xref="PDB:2CHS" /db_xref="PDB:2CHT" /db_xref="PDB:3ZO8" /db_xref="PDB:3ZOP" /db_xref="PDB:3ZP4" /db_xref="PDB:3ZP7" /db_xref="SubtiList:BG10286" /db_xref="UniProtKB/Swiss-Prot:P19080" /translation="MMIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQ MLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQD QIRHVYLEKVVVLRPDLSLTKNTEL*" gene complement(2243230..2243613) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" promotor_-35 complement(2243249..2243256) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-35" CDS complement(2243610..2244698) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" /EC_number="4.2.3.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate synthase" /protein_id="NP_390151.1" /db_xref="EnsemblGenomes-Gn:BSU22700" /db_xref="EnsemblGenomes-Tr:CAB14186" /db_xref="GOA:P31102" /db_xref="InterPro:IPR016037" /db_xref="InterPro:IPR030960" /db_xref="InterPro:IPR030963" /db_xref="SubtiList:BG10285" /db_xref="UniProtKB/Swiss-Prot:P31102" /translation="MKTLHVQTASSSYPVFIGQGIRKKACELLTSLNRPLTRIMFVTD EEVDRLYGDEMLHLLQEKWPVKKVTVPSGEQAKSMDMYTKLQSEAIRFHMDRSSCIIA FGGGVVGDLAGFVAATFMRGIDFIQMPTTLLAHDSAVGGKVAVNHPLGKNLIGAFYQP KAVLYDTDFLRSLPEKELRSGMAEVIKHAFIYDRAFLEELLNIHSLRDITNDQLNDMI FKGISIKASVVQQDEKEEGIRAYLNFGHTLGHAVEAEYGYGQITHGDAVALGMQFALY ISEKTVGCEMDRKRLVSWLKSLGYPSQIRKETETSVLLNRMMNDKKTRGGKIQFIVLN ELGKVADHTFSRNELESWLNKWRLEETS*" gene complement(2243610..2244698) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" promotor_-10 complement(2243739..2243754) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(2243752) /Source="Nicolas_upshifts" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" promotor_-35 complement(2243767..2243775) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(2244698..2245870) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" /EC_number="4.2.3.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 10518299, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 10518299, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate synthase" /protein_id="NP_390152.3" /db_xref="EnsemblGenomes-Gn:BSU22710" /db_xref="EnsemblGenomes-Tr:CAB14187" /db_xref="GOA:P31104" /db_xref="InterPro:IPR000453" /db_xref="InterPro:IPR020541" /db_xref="InterPro:IPR035904" /db_xref="SubtiList:BG10284" /db_xref="UniProtKB/Swiss-Prot:P31104" /translation="MRYLTAGESHGPQLTTIIEGVPAGLYITEEDINFELARRQKGHG RGRRMQIEKDQAKIMSGVRHARTLGSPIALVVENNDWKHWTKIMGAAPITEDEEKEMK RQISRPRPGHADLNGAIKYNHRDMRNVLERSSARETTVRVAAGAVAKKILSELGIKVA GHVLQIGAVKAEKTEYTSIEDLQRVTEESPVRCYDEEAGKKMMAAIDEAKANGDSIGG IVEVIVEGMPVGVGSYVHYDRKLDSKLAAAVLSINAFKGVEFGIGFEAAGRNGSEVHD EIIWDEEKGYTRATNRLGGLEGGMTTGMPIVVRGVMKPIPTLYKPLKSVDIETKEPFS ASIERSDSCAVPAASVVAEAAVAWEIANAVVEQFGLDQIDRIRENVENMRKLSREF*" gene complement(2244698..2245870) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" promotor_-10 complement(2245905..2245924) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2245922) /Source="Nicolas_upshifts" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" promotor_-35 complement(2245937..2245944) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(2245945..2246715) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" /EC_number="2.1.1.80" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis proteins (MCPs) methyltransferase" /protein_id="NP_390153.2" /db_xref="EnsemblGenomes-Gn:BSU22720" /db_xref="EnsemblGenomes-Tr:CAB14188" /db_xref="GOA:P31105" /db_xref="InterPro:IPR000780" /db_xref="InterPro:IPR022641" /db_xref="InterPro:IPR022642" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036804" /db_xref="PDB:5FTW" /db_xref="SubtiList:BG10283" /db_xref="UniProtKB/Swiss-Prot:P31105" /translation="MDTYSVFTTKWKQLTGVDLTLYKEAQMKRRLTSLYEKKGFQSFK DFAAALEKDQALLNETLDRMTINVSEFYRNYKRWEVLETAILPLIKTSRPLKIWSAAC STGEEPYTLAMLLDQQKGLPGYQILATDIDEKALEKAKKGVYQERSLQEVPLSVKDRY FTQNANRSYEVKTEIKKNITFKKHNLLADRYEQDFDLIVCRNVFIYFTESAKEELYLK MAHSLKKNGVLFVGSTEQIFNPEKFGLVPADTFFYQKR*" gene complement(2245945..2246715) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" promotor_-10 complement(2246741..2246760) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2246758) /Source="Nicolas_upshifts" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" promotor_-35 complement(2246772..2246778) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" S_feature complement(2246790..2246951) /Source="Nicolas_S_feature" /locus_tag="new_2381192_2381353_c" /HighExp="M0t90, Lbstat, S0, Mt0, M0t45, M40t90, Lbtran, Mal, G/S, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.996, 0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S858" downshifts complement(2246833) /Source="Nicolas_upshifts" /id="D1185" /incds=0 /nref=26 /ntot=128 /MaxReadThrough="4.04342" /MaxDrop="4.7493" /score="29.2259705" /energy="-8.6" /TU="U1777,U1778,U1779,U1780" /idTUdmin="U1778" /TUdmin="-880" /isTUend="FALSE" CDS complement(2246952..2247401) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" /EC_number="2.7.4.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 11734624, 22720735, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside diphosphate kinase" /protein_id="NP_390154.1" /db_xref="EnsemblGenomes-Gn:BSU22730" /db_xref="EnsemblGenomes-Tr:CAB14189" /db_xref="GOA:P31103" /db_xref="InterPro:IPR001564" /db_xref="InterPro:IPR023005" /db_xref="InterPro:IPR034907" /db_xref="InterPro:IPR036850" /db_xref="SubtiList:BG10282" /db_xref="UniProtKB/Swiss-Prot:P31103" /translation="MMEKTFIMVKPDGVQRQLIGDILSRFERKGLQLAGAKLMRVTEQ MAEKHYAEHQGKPFFGELVEFITSGPVFAMVWEGENVIEVTRQLIGKTNPKEALPGTI RGDYGMFVGKNIIHGSDSLESAEREINIFFKNEELVSYQQLMAGWIY*" gene complement(2246952..2247401) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" promotor_-10 complement(2247444..2247463) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(2247451) /Source="Nicolas_upshifts" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" promotor_-35 complement(2247476..2247483) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(2247517..2248563) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" /EC_number="2.5.1.30" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component II" /protein_id="NP_390155.1" /db_xref="EnsemblGenomes-Gn:BSU22740" /db_xref="EnsemblGenomes-Tr:CAB14190" /db_xref="GOA:P31114" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR014119" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG10281" /db_xref="UniProtKB/Swiss-Prot:P31114" /translation="MLNIIRLLAESLPRISDGNENTDVWVNDMKFKMAYSFLNDDIDV IERELEQTVRSDYPLLSEAGLHLLQAGGKRIRPVFVLLSGMFGDYDINKIKYVAVTLE MIHMASLVHDDVIDDAELRRGKPTIKAKWDNRIAMYTGDYMLAGSLEMMTRINEPKAH RILSQTIVEVCLGEIEQIKDKYNMEQNLRTYLRRIKRKTALLIAVSCQLGAIASGADE KIHKALYWFGYYVGMSYQIIDDILDFTSTEEELGKPVGGDLLQGNVTLPVLYALKNPA LKNQLKLINSETTQEQLEPIIEEIKKTDAIEASMAVSEMYLQKAFQKLNTLPRGRARS SLAAIAKYIGKRKF*" gene complement(2247517..2248563) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" CDS complement(2248505..2249206) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" /EC_number="2.1.1.163" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16279806, 9045837, 9139683, 21513522, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16279806, 9045837, 9139683, 21513522, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="demethylmenaquinone methyltransferase" /protein_id="NP_390156.1" /db_xref="EnsemblGenomes-Gn:BSU22750" /db_xref="EnsemblGenomes-Tr:CAB14191" /db_xref="GOA:P31113" /db_xref="InterPro:IPR004033" /db_xref="InterPro:IPR014122" /db_xref="InterPro:IPR023576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10280" /db_xref="UniProtKB/Swiss-Prot:P31113" /translation="MQDSKEQRVHGVFEKIYKNYDQMNSVISFQQHKKWRDKTMRIMN VKEGAKALDVCCGTADWTIALAKAAGKSGEIKGLDFSENMLSVGEQKVKDGGFSQIEL LHGNAMELPFDDDTFDYVTIGFGLRNVPDYLTVLKEMRRVVKPGGQVVCLETSQPEMF GFRQAYFMYFKYIMPFFGKLFAKSYKEYSWLQESARDFPGMKELAGLFEEAGLKNVKY HSFTGGVAATHIGWK*" gene complement(2248505..2249206) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" CDS complement(2249213..2249968) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" /EC_number="2.5.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component I" /protein_id="NP_390157.1" /db_xref="EnsemblGenomes-Gn:BSU22760" /db_xref="EnsemblGenomes-Tr:CAB14192" /db_xref="GOA:P31112" /db_xref="InterPro:IPR009920" /db_xref="SubtiList:BG10279" /db_xref="UniProtKB/Swiss-Prot:P31112" /translation="MQDIYGTLANLNTKLKQKLSHPYLAKHISAPKIDEDKLLLFHAL FEEADIKNNDRENYIVTAMLVQSALDTHDEVTTARVIKRDENKNRQLTVLAGDYFSGL YYSLLSEMKDIYMIRTLATAIKEINEHKIRLYDRSFKDENDFFESVGIVESALFHRVA EHFNLPRWKKLSSDFFVFKRLMNGNDAFLDVIGSFIQLGKTKEEILEDCFKKAKNSIE SLLPLNSPIQNILINRLKTISQDQTYHQKVEEG*" gene complement(2249213..2249968) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" S_feature complement(2249969..2250054) /Source="Nicolas_S_feature" /locus_tag="new_2384371_2384456_c" /HighExp="H2O2, G150, G180, Paraq, Oxctl, G135, T-4.40H, Lbexp, T-3.40H, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S859" promotor_-10 complement(2250043..2250062) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2250054) /Source="Nicolas_upshifts" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" promotor_-35 complement(2250073..2250080) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(2250132..2250359) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15099736, 15588817, 16285852, 16306262, 17114058, 28069823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15099736, 15588817, 16285852, 16306262, 17114058, 28069823; Product type r : regulator" /codon_start=1 /transl_table=11 /product="tryptophan operon RNA-binding attenuation protein (TRAP)" /protein_id="NP_390158.1" /db_xref="EnsemblGenomes-Gn:BSU22770" /db_xref="EnsemblGenomes-Tr:CAB14193" /db_xref="GOA:P19466" /db_xref="InterPro:IPR000824" /db_xref="InterPro:IPR016031" /db_xref="InterPro:IPR023558" /db_xref="PDB:1WAP" /db_xref="PDB:3ZZQ" /db_xref="PDB:4B27" /db_xref="SubtiList:BG10278" /db_xref="UniProtKB/Swiss-Prot:P19466" /translation="MNQKHSSDFVVIKAVEDGVNVIGLTRGTDTKFHHSEKLDKGEVI IAQFTEHTSAIKVRGEALIQTAYGEMKSEKK*" gene complement(2250132..2250359) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" downshifts complement(2250153) /Source="Nicolas_upshifts" /id="D1186" /incds=0 /nref=22 /ntot=162 /MaxReadThrough="6.02348" /MaxDrop="4.385" /score="8.50521108" /energy="-10.5" /TU="U1779,U1780" /idTUdmin="U1781" /TUdmin=1499 /isTUend="FALSE" CDS complement(2250381..2250953) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1551827, 12559918, 14717702, 17032654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1551827, 12559918, 14717702, 17032654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_390159.1" /db_xref="EnsemblGenomes-Gn:BSU22780" /db_xref="EnsemblGenomes-Tr:CAB14194" /db_xref="GOA:P19465" /db_xref="InterPro:IPR001474" /db_xref="InterPro:IPR018234" /db_xref="InterPro:IPR020602" /db_xref="SubtiList:BG10277" /db_xref="UniProtKB/Swiss-Prot:P19465" /translation="MKEVNKEQIEQAVRQILEAIGEDPNREGLLDTPKRVAKMYAEVF SGLNEDPKEHFQTIFGENHEELVLVKDIAFHSMCEHHLVPFYGKAHVAYIPRGGKVTG LSKLARAVEAVAKRPQLQERITSTIAESIVETLDPHGVMVVVEAEHMCMTMRGVRKPG AKTVTSAVRGVFKDDAAARAEVLEHIKRQD*" gene complement(2250381..2250953) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" promotor_-10 complement(2250982..2251001) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2250992) /Source="Nicolas_upshifts" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" S_feature complement(2250994..2251077) /Source="Nicolas_S_feature" /locus_tag="new_2385396_2385479_c" /HighExp="Oxctl, G150, G180, G135, LBGexp, Paraq, LPh, H2O2, aero, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S860" promotor_-35 complement(2251014..2251020) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" downshifts complement(2251122) /Source="Nicolas_upshifts" /id="D1187" /incds=0 /nref=33 /ntot=254 /MaxReadThrough="6.68474" /MaxDrop="5.1938" /score="8.50521108" /energy="-10.5" /TU="U1780" /idTUdmin="U1781" /TUdmin=530 /isTUend="FALSE" CDS complement(2251141..2251419) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" /function="16.1: Circulate" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617; Product type f: factor" /codon_start=1 /transl_table=11 /product="non-specific DNA-binding protein HBsu" /protein_id="NP_390160.1" /db_xref="EnsemblGenomes-Gn:BSU22790" /db_xref="EnsemblGenomes-Tr:CAB14195" /db_xref="GOA:P08821" /db_xref="InterPro:IPR000119" /db_xref="InterPro:IPR010992" /db_xref="InterPro:IPR020816" /db_xref="SubtiList:BG10276" /db_xref="UniProtKB/Swiss-Prot:P08821" /translation="MNKTELINAVAEASELSKKDATKAVDSVFDTILDALKNGDKIQL IGFGNFEVRERSARKGRNPQTGEEIEIPASKVPAFKPGKALKDAVAGK*" gene complement(2251141..2251419) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" S_feature complement(2251420..2251645) /Source="Nicolas_S_feature" /locus_tag="new_2385822_2386047_c" /HighExp="dia5, C90, T-0.40H, G/S, S1, Salt, Lbexp, dia15, T-1.40H, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S861" promotor_-10 complement(2251627..2251646) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2251645) /Source="Nicolas_upshifts" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" promotor_-35 complement(2251663..2251668) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(2251793..2253271) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11160095, 17114257, 17427285, 24810258, 26387458, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160095, 17114257, 17427285, 24810258, 26387458, 28408070; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="morphogenetic stage IV sporulation protein" /protein_id="NP_390161.1" /db_xref="EnsemblGenomes-Gn:BSU22800" /db_xref="EnsemblGenomes-Tr:CAB14196" /db_xref="GOA:P35149" /db_xref="InterPro:IPR014201" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10275" /db_xref="UniProtKB/Swiss-Prot:P35149" /translation="MEKVDIFKDIAERTGGDIYLGVVGAVRTGKSTFIKKFMELVVLP NISNEADRARAQDELPQSAAGKTIMTTEPKFVPNQAMSVHVSDGLDVNIRLVDCVGYT VPGAKGYEDENGPRMINTPWYEEPIPFHEAAEIGTRKVIQEHSTIGVVITTDGTIGDI ARSDYIEAEERVIEELKEVGKPFIMVINSVRPYHPETEAMRQDLSEKYDIPVLAMSVE SMRESDVLSVLREALYEFPVLEVNVNLPSWVMVLKENHWLRESYQESVKETVKDIKRL RDVDRVVGQFSEFEFIESAGLAGIELGQGVAEIDLYAPDHLYDQILKEVVGVEIRGRD HLLELMQDFAHAKTEYDQVSDALKMVKQTGYGIAAPALADMSLDEPEIIRQGSRFGVR LKAVAPSIHMIKVDVESEFAPIIGTEKQSEELVRYLMQDFEDDPLSIWNSDIFGRSLS SIVREGIQAKLSLMPENARYKLKETLERIINEGSGGLIAIIL*" gene complement(2251793..2253271) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" downshifts complement(2251806) /Source="Nicolas_upshifts" /id="D1188" /incds=0 /nref=59 /ntot=76 /MaxReadThrough="3.43222" /MaxDrop="7.13908" /score="13.6316529" /energy="-9.2" /TU="U1781" /idTUdmin="U1782" /TUdmin=0 /isTUend="TRUE" S_feature complement(2253272..2253433) /Source="Nicolas_S_feature" /locus_tag="new_2387674_2387835_c" /HighExp="S3, S4, S5, S6, LoTm, S7, B36, BT, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S862" promotor_-10 complement(2253420..2253438) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-10" upshifts complement(2253445) /Source="Nicolas_upshifts" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" CDS complement(2253452..2254186) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein of unknown function" /protein_id="NP_390162.1" /db_xref="EnsemblGenomes-Gn:BSU22810" /db_xref="EnsemblGenomes-Tr:CAB14197" /db_xref="SubtiList:BG10274" /db_xref="UniProtKB/Swiss-Prot:P39911" /translation="MGKLKCAIIFAAVVFLSGCLYPNERKSSVHAIPYQDQLKQVQSA VDEFQKANGGLLPIQTKDMSTPLYQKYPIDFNRLAPRYIAEPPSTAFESGGDYQYVLV DVENDPTVKLIDLKMAEKIRDVKLRIQMYRQEHQYPPYKDVLSRDLFTLDEKKLGDGS SLTVTSPISGNSLPLMIDGDGEIYADYRTELASCLKKSKKTFKPGTEIQDMIWHETPF VPAFSVKYTVNDKQEPVFLENDMKKE*" gene complement(2253452..2254186) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" promotor_-35 complement(2253453..2253458) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-35" downshifts complement(2253478) /Source="Nicolas_upshifts" /id="D1189" /incds=0 /nref=6 /ntot=78 /MaxReadThrough="6.50932" /MaxDrop="4.759" /score="15.8109079" /energy="-12.7" /TU="U1782" /idTUdmin="U1783" /TUdmin=1100 /isTUend="FALSE" CDS complement(2254208..2254411) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390163.1" /db_xref="EnsemblGenomes-Gn:BSU22820" /db_xref="EnsemblGenomes-Tr:CAB14198" /db_xref="GOA:P50744" /db_xref="InterPro:IPR020076" /db_xref="SubtiList:BG11444" /db_xref="UniProtKB/Swiss-Prot:P50744" /translation="MNLALMKMWFALGSMGLMFLAVASIYLSRFKCQNRFLKIAISSF AYMCMLISGIIVFVVVFSGPVNE*" gene complement(2254208..2254411) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" promotor_-10 complement(2254447..2254466) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2254468) /Source="Nicolas_upshifts" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" promotor_-35 complement(2254480..2254487) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2254533..2254732) /Source="Nicolas_S_feature" /locus_tag="new_2388935_2389134_c" /HighExp="S7, S8, S6, C30, BT, G135, G180, Oxctl, Cold, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, Sig-" /TUshortPSig="1, 1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S863" downshifts complement(2254576) /Source="Nicolas_upshifts" /id="D1190" /incds=0 /nref=264 /ntot=295 /MaxReadThrough="2.22999" /MaxDrop="8.05743" /score="26.216597" /energy="-14.1" /TU="NA" /idTUdmin="U1783" /TUdmin=2 /isTUend="TRUE" promotor_-10 complement(2254707..2254726) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2254732) /Source="Nicolas_upshifts" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" promotor_-35 complement(2254740..2254749) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2254749..2255786) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" /EC_number="1.1.1.94" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592341, 12682299, 15557260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592341, 12682299, 15557260; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent glycerol-3-phosphate dehydrogenase" /protein_id="NP_390164.1" /db_xref="EnsemblGenomes-Gn:BSU22830" /db_xref="EnsemblGenomes-Tr:CAB14199" /db_xref="GOA:P46919" /db_xref="InterPro:IPR006109" /db_xref="InterPro:IPR006168" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR011128" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11366" /db_xref="UniProtKB/Swiss-Prot:P46919" /translation="MKKVTMLGAGSWGTALALVLTDNGNEVCVWAHRADLIHQINELH ENKDYLPNVKLSTSIKGTTDMKEAVSDADVIIVAVPTKAIREVLRQAVPFITKKAVFV HVSKGIEPDSLLRISEIMEIELPSDVRKDIVVLSGPSHAEEVGLRHPTTVTASSKSMR AAEEVQDLFINHNFRVYTNPDIIGVEIGGALKNIIALAAGITDGLGYGDNAKAALITR GLAEIARLGTKMGGNPLTFSGLTGVGDLIVTCTSVHSRNWRAGNLLGKGYKLEDVLEE MGMVVEGVRTTKAAYQLSKKYDVKMPITEALHQVLFNGQKVETAVESLMARGKTHEME DLVNTFENQVK*" gene complement(2254749..2255786) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" CDS complement(2255804..2257114) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" /EC_number="3.6.5.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase essential for ribosome 50S subunit assembly (maturation of the 50S subunit central protoberance)" /protein_id="NP_390165.1" /db_xref="EnsemblGenomes-Gn:BSU22840" /db_xref="EnsemblGenomes-Tr:CAB14200" /db_xref="GOA:P50743" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR016484" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031166" /db_xref="InterPro:IPR032859" /db_xref="PDB:2HJG" /db_xref="PDB:4DCS" /db_xref="PDB:4DCT" /db_xref="PDB:4DCU" /db_xref="PDB:4DCV" /db_xref="PDB:4KYU" /db_xref="PDB:5X4B" /db_xref="SubtiList:BG11443" /db_xref="UniProtKB/Swiss-Prot:P50743" /translation="MGKPVVAIVGRPNVGKSTIFNRIAGERISIVEDTPGVTRDRIYS SAEWLNYDFNLIDTGGIDIGDEPFLAQIRQQAEIAMDEADVIIFMVNGREGVTAADEE VAKILYRTKKPVVLAVNKLDNTEMRANIYDFYSLGFGEPYPISGTHGLGLGDLLDAVA EHFKNIPETKYNEEVIQFCLIGRPNVGKSSLVNAMLGEERVIVSNVAGTTRDAVDTSF TYNQQEFVIVDTAGMRKKGKVYETTEKYSVLRALKAIDRSEVVAVVLDGEEGIIEQDK RIAGYAHEAGKAVVIVVNKWDAVDKDESTMKEFEENIRDHFQFLDYAPILFMSALTKK RIHTLMPAIIKASENHSLRVQTNVLNDVIMDAVAMNPTPTHNGSRLKIYYATQVSVKP PSFVVFVNDPELMHFSYERFLENRIRDAFGFEGTPIKIFARARK*" gene complement(2255804..2257114) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" S_feature complement(2257115..2257239) /Source="Nicolas_S_feature" /locus_tag="new_2391517_2391641_c" /HighExp="Cold, G180, G150, Oxctl, G135, C30, LBGexp, Paraq, dia0, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S864" promotor_-10 complement(2257225..2257244) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2257239) /Source="Nicolas_upshifts" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" promotor_-35 complement(2257259..2257262) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2257268..2257462) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097755.1" /db_xref="EnsemblGenomes-Gn:BSU22849" /db_xref="EnsemblGenomes-Tr:CAX52654" /db_xref="UniProtKB/Swiss-Prot:C0H445" /translation="MSESLTKVILSVITTNRNRVAGGAPVFFCNDQKEMELFAKNLEA ILDGIAHRIGDDVYLIVKHF*" gene complement(2257268..2257462) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" CDS complement(2257459..2258352) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390166.1" /db_xref="EnsemblGenomes-Gn:BSU22850" /db_xref="EnsemblGenomes-Tr:CAB14201" /db_xref="GOA:P50742" /db_xref="InterPro:IPR025918" /db_xref="SubtiList:BG11442" /db_xref="UniProtKB/Swiss-Prot:P50742" /translation="MSDYIYPIIAGVIAGIATRLYMLKTDYRQYPTYVHGKVIHIALG LIAAGLGAIIMPALLQEEFTAITFLTLAATQFRDVRNMERNTLTQMDSYELVSRGSTY IEGIAIAFESRNYIVIFTALLTTSAYVFLSIWAAVIAAVVCFLLAMKFMSGSVLKDIV DIEYIKPRFDGPGLFVDNIYMMNIGLPEKQELILKHGMGFILTPKNFNSAATIANLGQ RQAILFDVSNVLGVYRDSGEPSLTPIAKRDLNDGRVAVFVLPQIHHPETAVQIISNVP TLENAIRMPTEFIKNQDKVIG*" gene complement(2257459..2258352) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" CDS complement(2258349..2258948) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390167.1" /db_xref="EnsemblGenomes-Gn:BSU22860" /db_xref="EnsemblGenomes-Tr:CAB14202" /db_xref="GOA:P50741" /db_xref="InterPro:IPR014617" /db_xref="SubtiList:BG11441" /db_xref="UniProtKB/Swiss-Prot:P50741" /translation="MEQFYYYWSMWFLWVLTTFIFEKTKRRIAVSVFILTNIILSIHD IALYFSLNAAYLMFFVCGCVYAGYLGMYRFRYIMVYLTLVAAYAFVYLFALYDPVWFI IKPEWAAVILIVLLTASVERNFEKQLVLFVLGMCQGELVYSFVIQKLAGAMAVGGFQW LNACSAGMILLFGISKYEHLASQIGQKSKRSNKGATKMS*" gene complement(2258349..2258948) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" promotor_-35 2258821..2258827 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2258836..2259019 /Source="Nicolas_S_feature" /locus_tag="new_2393238_2393421" /HighExp="S5, S8, S6, S7, BT, S4, ferm, nit, Pyr, G/S" /AntisenseName="yphA" /AntisenseCor="0.73324773408178501" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.6" /TUlongSig="NA" /TUlongPSig="NA" /label="S865" upshifts 2258838 /Source="Nicolas_upshifts" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" promotor_-10 2258841..2258852 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2258959..2258977) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2258978) /Source="Nicolas_upshifts" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" promotor_-35 complement(2258993..2258998) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2259026..2259157 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="YP_003097756.2" /db_xref="EnsemblGenomes-Gn:BSU22869" /db_xref="EnsemblGenomes-Tr:CAX52655" /db_xref="InterPro:IPR025414" /db_xref="UniProtKB/Swiss-Prot:C0H446" /translation="MGKDRQEKKLKASGRVESDRDQSIHYDGATSLEQNGRFKKRKS* " gene 2259026..2259157 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" downshifts 2259145 /Source="Nicolas_upshifts" /id="D1191" /incds=0 /nref=37 /ntot=122 /MaxReadThrough="0.20384" /MaxDrop="6.94664" /score="3.33160455" /energy="-13.2" /TU="NA" /idTUdmin="U1785" /TUdmin=1 /isTUend="TRUE" CDS complement(2259200..2260249) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" /EC_number="5.3.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12798687, 14745175, 15206931" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12798687, 14745175, 15206931; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl diphosphate isomerase (typeII)" /protein_id="NP_390168.3" /db_xref="EnsemblGenomes-Gn:BSU22870" /db_xref="EnsemblGenomes-Tr:CAB14203" /db_xref="GOA:P50740" /db_xref="InterPro:IPR000262" /db_xref="InterPro:IPR011179" /db_xref="InterPro:IPR013785" /db_xref="PDB:1P0K" /db_xref="PDB:1P0N" /db_xref="SubtiList:BG11440" /db_xref="UniProtKB/Swiss-Prot:P50740" /translation="MTRAERKRQHINHALSIGQKRETGLDDITFVHVSLPDLALEQVD ISTKIGELSSSSPIFINAMTGGGGKLTYEINKSLARAASQAGIPLAVGSQMSALKDPS ERLSYEIVRKENPNGLIFANLGSEATAAQAKEAVEMIGANALQIHLNVIQEIVMPEGD RSFSGALKRIEQICSRVSVPVIVKEVGFGMSKASAGKLYEAGAAAVDIGGYGGTNFSK IENLRRQRQISFFNSWGISTAASLAEIRSEFPASTMIASGGLQDALDVAKAIALGASC TGMAGHFLKALTDSGEEGLLEEIQLILEELKLIMTVLGARTIADLQKAPLVIKGETHH WLTERGVNTSSYSVR*" gene complement(2259200..2260249) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" downshifts complement(2259220) /Source="Nicolas_upshifts" /id="D1192" /incds=0 /nref=209 /ntot=250 /MaxReadThrough="1.39069" /MaxDrop="4.82362" /score="15.2467448" /energy="-13.2" /TU="NA" /idTUdmin="U1788" /TUdmin=0 /isTUend="TRUE" downshifts complement(2260124) /Source="Nicolas_upshifts" /id="D1193" /incds=1 /nref=45 /ntot=237 /MaxReadThrough="6.15611" /MaxDrop="4.91722" /score="13.2731686" /energy="-15.7" /TU="U1788,U1789,U1790" /idTUdmin="U1788" /TUdmin="-904" /isTUend="FALSE" CDS complement(2260262..2261410) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 9862121, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA degradation presenting factor (ribosomal protein S1 homolog)" /protein_id="NP_390169.1" /db_xref="EnsemblGenomes-Gn:BSU22880" /db_xref="EnsemblGenomes-Tr:CAB14204" /db_xref="GOA:P38494" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11005" /db_xref="UniProtKB/Swiss-Prot:P38494" /translation="MTEEMNQIDVQVPEVGDVVKGIVTKVEDKHVDVEIINVKQSGII PISELSSLHVEKASDVVKVDDELDLKVTKVEDDALILSKRAVDADRAWEDLEKKFETK EVFEAEVKDVVKGGLVVDIGVRGFIPASLVEAHFVEDFTDYKGKTLSLLVVELDRDKN RVILSHRAVVESEQANKKQELLQSLEVGSVLDGKVQRLTDFGAFVDIGGIDGLVHISQ LSHSHVEKPSDVVEEGQEVKVKVLSVDRDNERISLSIKDTLPGPWNQIGEKVKPGDVL EGTVQRLVSFGAFVEILPGVEGLVHISQISNKHIGTPHEVLEEGQTVKVKVLDVNENE ERISLSMRELEETPKADQEDYRQYQAKEETSTGFQLGDLIGDKLNKLK*" gene complement(2260262..2261410) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" misc_feature 2260591..2260594 /Source="Nicolas_upshift_promotors" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2260618 /Source="Nicolas_upshifts" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2260684 /Source="Nicolas_upshifts" /id="D1194" /incds=1 /nref=1 /ntot=124 /MaxReadThrough="1.88188" /MaxDrop="2.8624" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=0 /isTUend="TRUE" downshifts 2261388 /Source="Nicolas_upshifts" /id="D1195" /incds=0 /nref=3 /ntot=200 /MaxReadThrough="1.33117" /MaxDrop="3.08345" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=704 /isTUend="FALSE" S_feature complement(2261411..2261550) /Source="Nicolas_S_feature" /locus_tag="new_2395813_2395952_c" /HighExp="C90, Salt, Etha, Lbtran, HiOs, M40t90, S1, LBGtran, LoTm, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.999, 0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S866" promotor_-10 complement(2261549..2261568) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2261550) /Source="Nicolas_upshifts" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" S_feature complement(2261552..2261642) /Source="Nicolas_S_feature" /locus_tag="new_2395954_2396044_c" /HighExp="G135, G180, LBGexp, C30, Cold, Oxctl, dia0, G150, Paraq, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40511799999999998" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S867" promotor_-35 complement(2261583..2261590) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2261643..2262317) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" /EC_number="2.7.4.25" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8576266, 9179491, 9862121, 11827479, 12682299, 16880539" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576266, 9179491, 9862121, 11827479, 12682299, 16880539; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidylate kinase" /protein_id="NP_390170.1" /db_xref="EnsemblGenomes-Gn:BSU22890" /db_xref="EnsemblGenomes-Tr:CAB14205" /db_xref="GOA:P38493" /db_xref="InterPro:IPR003136" /db_xref="InterPro:IPR011994" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11004" /db_xref="UniProtKB/Swiss-Prot:P38493" /translation="MEKKLSIAIDGPAAAGKSTVAKIVAEKKSYIYIDTGAMYRAITY AALQENVDLTDEEKLAELLKRTDIELITTKDGQKVFVNGTDVTEAIRTDEISNQVSIA AKHRSVREEMVKRQQQLGEKGGVVMDGRDIGTHVLPNAEVKIFLLASVEERAKRRYEE NVKKGFDVNYETLIEEIARRDKLDSEREVSPLRKAEDALEIDTTSLSIQEVADKILEA VEQKSR*" gene complement(2261643..2262317) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" S_feature complement(2262318..2262395) /Source="Nicolas_S_feature" /locus_tag="new_2396720_2396797_c" /HighExp="S4, S5, S7, S8, S6, dia15, S3, Diami, dia5, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S868" CDS complement(2262396..2262572) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390171.1" /db_xref="EnsemblGenomes-Gn:BSU22900" /db_xref="EnsemblGenomes-Tr:CAB14206" /db_xref="InterPro:IPR035281" /db_xref="SubtiList:BG11003" /db_xref="UniProtKB/Swiss-Prot:P38492" /translation="MKTFERLLIKLLFIQAIILLGVQFLFHYQHIEPYVSKVIQYEGV DKMEENNRIETFKH*" gene complement(2262396..2262572) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" promotor_-10 complement(2262584..2262602) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2262601) /Source="Nicolas_upshifts" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" promotor_-35 complement(2262617..2262623) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2262617..2263270) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16249258, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16249258, 23893111, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic di-GMP receptor" /protein_id="NP_390172.1" /db_xref="EnsemblGenomes-Gn:BSU22910" /db_xref="EnsemblGenomes-Tr:CAB14207" /db_xref="GOA:P38491" /db_xref="InterPro:IPR009875" /db_xref="InterPro:IPR009926" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG11002" /db_xref="UniProtKB/Swiss-Prot:P38491" /translation="MIEIGENVLLEYIEENELKKAKSKAVSIENNELLIAYPVDVVTG RTVILHNDMEVTVEFVGKDEVPYRFISRIKGKVKDKLQMICLEMPPREKMKRIQRRQY VRTDAVLDVQIQPGNEEEIRTLSYNISAGGIAVVLADGLSFQSGESLRLIIRLPEEEH TRQIETEAVVRRIFNDPKSEKRKMTLEYSEIAAGDQQALLQYCIRRQLNKRRKARME* " gene complement(2262617..2263270) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" promotor_-10 complement(2263300..2263319) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2263313) /Source="Nicolas_upshifts" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" promotor_-35 complement(2263335..2263339) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2263363..2264715) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination membrane component" /protein_id="NP_390173.1" /db_xref="EnsemblGenomes-Gn:BSU22920" /db_xref="EnsemblGenomes-Tr:CAB14208" /db_xref="GOA:P38490" /db_xref="InterPro:IPR014239" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG11001" /db_xref="UniProtKB/Swiss-Prot:P38490" /translation="MIRGILIAVLGIAIVGTGYWGYKEHQEKDAVLLHAENNYQRAFH ELTYQVDQLHDKIGTTLAMNSQKSLSPALIDVWRITSEAHNSVSQLPLTLMPFNKTEE LLSKIGDFSYKTSVRDLDQKPLDKNEYTSLNKLYQQSEDIQNELRHVQHLVMSKNLRW MDVEMALASDEKQSDNTIINSFKTVEKNVGAFSTGTDLGPSFTSTKKEEKGFSHLKGK QISEQEAKQIAERFAPDDNYSIKVVKSGKKTNRDVYSISMKDPDHKAVIYMDITKKGG HPVYLIQNREVKDQKISLNDGSNRALAFLKKNGFETDDLEIDESAQYDKIGVFSYVPV ENKVRMYPEAIRMKVALDDGEVVGFSARDFLTSHRKRTIPKPAITEAEAKSKLNKNVQ VRETRLALITNELGQEVLCYEMLGTIENDTFRMYINAKDGSEEKVEKLKNAEPIYKDL *" gene complement(2263363..2264715) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" downshifts complement(2263378) /Source="Nicolas_upshifts" /id="D1196" /incds=0 /nref=21 /ntot=44 /MaxReadThrough="0.647060000000002" /MaxDrop="5.74199" /score="16.6521528" /energy="-10.1" /TU="NA" /idTUdmin="U1791" /TUdmin=0 /isTUend="TRUE" CDS complement(2264750..2265667) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination cortex-lytic enzyme" /protein_id="NP_390174.1" /db_xref="EnsemblGenomes-Gn:BSU22930" /db_xref="EnsemblGenomes-Tr:CAB14209" /db_xref="GOA:P50739" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR011105" /db_xref="InterPro:IPR014224" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11439" /db_xref="UniProtKB/Swiss-Prot:P50739" /translation="MKSKGSIMACLILFSFTITTFINTETISAFSNQVIQRGATGDDV VELQARLQYNGYYNGKIDGVYGWGTYWAVRNFQDQFGLKEVDGLVGAKTKQTLICKSK YYREYVMEQLNKGNTFTHYGKIPLKYQTKPSKAATQKARQQAEARQKQPAEKTTQKPK ANANKQQNNTPAKARKQDAVAANMPGGFSNNDIRLLAQAVYGEARGEPYEGQVAIAAV ILNRLNSPLFPNSVAGVIFEPLAFTAVADGQIYMQPNETAREAVLDAINGWDPSEEAL YYFNPDTATSPWIWGRPQIKRIGKHIFCE*" gene complement(2264750..2265667) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" downshifts complement(2265138) /Source="Nicolas_upshifts" /id="D1197" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.35344" /MaxDrop="4.29326" /score="-3.16364421" /energy="-21.7" /TU="U1791,U1792" /idTUdmin="U1793" /TUdmin=682 /isTUend="FALSE" misc_feature complement(2265289..2265296) /Source="Nicolas_upshift_promotors" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2265292) /Source="Nicolas_upshifts" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" promotor_-10 complement(2265705..2265716) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2265714) /Source="Nicolas_upshifts" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" promotor_-35 complement(2265730..2265736) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2265806..2266462) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" /EC_number="3.4.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protease required for RsiW anti-sigma(W) degradation" /protein_id="NP_390175.1" /db_xref="EnsemblGenomes-Gn:BSU22940" /db_xref="EnsemblGenomes-Tr:CAB14210" /db_xref="GOA:P50738" /db_xref="InterPro:IPR023596" /db_xref="InterPro:IPR026898" /db_xref="SubtiList:BG11438" /db_xref="UniProtKB/Swiss-Prot:P50738" /translation="MFAIISAGIAPGIALLSYFYLKDQYDNEPVHMVLRSFFLGVVLV FPIMFIQYVLEKENVGGGSFFVSFLSSGFLEESLKWFILMISVYPHAHFDEHYDGIVY GASVSLGFATLENILYLIGHGVEHAFVRALLPVSCHALIGVIMGFYLGKARFSADKAR VKWLTLSLVVPSLLHGSYDFILTALSNWIYYMLPFMVFLWWFGLRKAKKARSVNMMQV *" gene complement(2265806..2266462) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" downshifts complement(2265820) /Source="Nicolas_upshifts" /id="D1198" /incds=0 /nref=239 /ntot=262 /MaxReadThrough="0.9181" /MaxDrop="6.61797" /score="-3.16364421" /energy="-21.7" /TU="NA" /idTUdmin="U1793" /TUdmin=0 /isTUend="TRUE" misc_feature complement(2266487..2266506) /Source="Nicolas_upshift_promotors" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2266502) /Source="Nicolas_upshifts" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" CDS complement(2266582..2267556) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" /EC_number="1.8.-.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacillithiol biosynthesis thiol disulfide oxidoreductase" /protein_id="NP_390176.2" /db_xref="EnsemblGenomes-Gn:BSU22950" /db_xref="EnsemblGenomes-Tr:CAB14211" /db_xref="GOA:P50736" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR023856" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11436" /db_xref="UniProtKB/Swiss-Prot:P50736" /translation="MIQEKAIIIGGGPCGLSAAIHLKQIGIDALVIEKGNVVNSIYNY PTHQTFFSSSEKLEIGDVAFITENRKPVRIQALSYYREVVKRKNIRVNAFEMVRKVTK TQNNTFVIETSKETYTTPYCIIATGYYDHPNYMGVPGEDLPKVFHYFKEGHPYFDKDV VVIGGKNSSVDAALELVKSGARVTVLYRGNEYSPSIKPWILPEFEALVRNGTIRMEFG ACVEKITENEVVFRSGEKELITIKNDFVFAMTGYHPDHQFLEKIGVEIDKETGRPFFN EETMETNVEGVFIAGVIAAGNNANEIFIENGRFHGGHIAAEIAKRENH*" gene complement(2266582..2267556) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" downshifts complement(2266590) /Source="Nicolas_upshifts" /id="D1199" /incds=0 /nref=239 /ntot=263 /MaxReadThrough="3.524" /MaxDrop="6.45954" /score="27.4058676" /energy="-12.2" /TU="U1796" /idTUdmin="U1796" /TUdmin="-748" /isTUend="FALSE" promotor_-35 2267410..2267415 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2267431..2267449 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2267441..2267634 /Source="Nicolas_S_feature" /locus_tag="new_2401843_2402036" /HighExp="S8, S6, S7, S4, S5, C30, S3, BT, B36, C90" /AntisenseName="ypdA" /AntisenseCor="-0.487730736536516" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S869" upshifts 2267441 /Source="Nicolas_upshifts" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" downshifts 2267592 /Source="Nicolas_upshifts" /id="D1200" /incds=0 /nref=13 /ntot=27 /MaxReadThrough="1.93985" /MaxDrop="5.69954" /score="23.7306175" /energy="-9.3" /TU="NA" /idTUdmin="U1794" /TUdmin=0 /isTUend="TRUE" CDS complement(2267665..2268948) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 18326565, 22178969, 22720735, 25610436" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 18326565, 22178969, 22720735, 25610436; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cryptic glutamate dehydrogenase (active after removal of a 9 bp insert)" /protein_id="NP_390177.2" /db_xref="EnsemblGenomes-Gn:BSU22960" /db_xref="EnsemblGenomes-Tr:CAB14212" /db_xref="GOA:P50735" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K8Z" /db_xref="SubtiList:BG11435" /db_xref="UniProtKB/Swiss-Prot:P50735" /translation="MAADRNTGHTEEDKLDVLKSTQTVIHKALEKLGYPEEVYELLKE PMRLLTVKIPVRMDDGSVKIFTGYRAQHNDSVGPTKGGIRFHPNVTEKEVKAVKALSI WMSLKCGIIDLPYGGGKGGIVCDPRDMSFRELERLSRGYVRAISQIVGPTKDVPAPDV FTNSQIMAWMMDEYSRIDEFNSPGFITGKPLVLGGSHGRESATAKGVTICIKEAAKKR GIDIKGARVVVQGFGNAGSYLAKFMHDAGAKVVGISDAYGGLYDPEGLDIDYLLDRRD SFGTVTKLFNDTITNQELLELDCDILVPAAIENQITEENAHNIRAKIVVEAANGPTTL EGTKILSDRDILLVPDVLASAGGVTVSYFEWVQNNQGFYWSEEEVEEKLEKMMVKSFN NIYEMANNRRIDMRLAAYMVGVRKMAEASRFRGWI*" gene complement(2267665..2268948) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" downshifts complement(2267668) /Source="Nicolas_upshifts" /id="D1201" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="7.92262" /MaxDrop="4.04542" /score="18.1400723" /energy="-9.3" /TU="U1796" /idTUdmin="U1797" /TUdmin=1345 /isTUend="FALSE" promotor_-35 2267706..2267712 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2267724..2267728 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2267724 /Source="Nicolas_upshifts" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2268991..2269010) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2269012) /Source="Nicolas_upshifts" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" promotor_-35 complement(2269025..2269032) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2269104..2269688) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914365, 19801546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914365, 19801546; Product type f: factor" /codon_start=1 /transl_table=11 /product="adaptor to ClpC; regulator of competence and sporulation" /protein_id="NP_390178.1" /db_xref="EnsemblGenomes-Gn:BSU22970" /db_xref="EnsemblGenomes-Tr:CAB14213" /db_xref="GOA:P50734" /db_xref="InterPro:IPR008681" /db_xref="PDB:3JTN" /db_xref="PDB:3JTO" /db_xref="SubtiList:BG11434" /db_xref="UniProtKB/Swiss-Prot:P50734" /translation="MRLERLNYNKIKIFLTLDDLTDRGLTKEDLWKDSFKVHQLFKDM MNEANTELGFEANGPIAVEVYSLQAQGMVVIVTKNQDADSEDDEYDDDYIEMQVKLDE SADIIYQFHSFEDIIQLSESLQRIGITGGTVYHYDGQYFLSLEDLGSHTAEGVVAVLA EYGNPTTLTIYRLQEYGKLIMDGNAVETIQTHFS*" gene complement(2269104..2269688) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" downshifts complement(2269106) /Source="Nicolas_upshifts" /id="D1202" /incds=0 /nref=258 /ntot=274 /MaxReadThrough="3.02006" /MaxDrop="7.92719" /score="23.8885529" /energy="-7.1" /TU="U1797" /idTUdmin="U1797" /TUdmin="-93" /isTUend="FALSE" S_feature complement(2269689..2269770) /Source="Nicolas_S_feature" /locus_tag="new_2404091_2404172_c" /HighExp="dia5, Diami, Etha, dia15, C90, Salt, LPhT, Heat, MG-0.2, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S870" promotor_-10 complement(2269763..2269782) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-10" upshifts complement(2269770) /Source="Nicolas_upshifts" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" promotor_-35 complement(2269796..2269803) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-35" CDS complement(2269847..2270626) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 17434969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390179.1" /db_xref="EnsemblGenomes-Gn:BSU22980" /db_xref="EnsemblGenomes-Tr:CAB14214" /db_xref="GOA:P50733" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11433" /db_xref="UniProtKB/Swiss-Prot:P50733" /translation="MKLSVKIAGVLTVAAAAMTAKMYATAKGNHLKTHTFPLSKMKGK PPLTIFFISDIHKRLIDQDLLEKARSHAPHLVIIGGDLAEGGVPSARIEENIKRLVHF GVPIVFVWGNNDYEVRQHKLYSIFKAHGVITLRNESVPFSYNGHTIAIAGVDDIRMEM DHYEEAIKELDESQLNILVCHNPEIHEQINEDDGIDVILSGHTHGGQIRFGKFGPYEL GKTGIVKNAAYLISNGYGTTKVPLRLGAEPETHIVTLCGPE*" gene complement(2269847..2270626) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" promotor_-10 complement(2270652..2270667) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-10" upshifts complement(2270663) /Source="Nicolas_upshifts" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" promotor_-35 complement(2270679..2270688) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-35" CDS complement(2270712..2271155) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390180.1" /db_xref="EnsemblGenomes-Gn:BSU22990" /db_xref="EnsemblGenomes-Tr:CAB14215" /db_xref="GOA:P50732" /db_xref="InterPro:IPR020210" /db_xref="SubtiList:BG11432" /db_xref="UniProtKB/Swiss-Prot:P50732" /translation="MESLWNQLDQFTDAPTKQMLQALVKRKQKFENYAAQCRRWRWAS LICLGLLCVMIMIKSPEPQLILQEILSHTFYLFWMLATAFAYCTSYYFKKKEEKSETD FHKLRCEIIQKSTDLWPQPDKWKARESVFHMMKHKYDINLYFESK*" gene complement(2270712..2271155) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" downshifts complement(2270729) /Source="Nicolas_upshifts" /id="D1203" /incds=0 /nref=4 /ntot=112 /MaxReadThrough="4.67294" /MaxDrop="3.33254" /score="6.86206051" /energy="-7.5" /TU="U1801" /idTUdmin="U1799" /TUdmin=22 /isTUend="TRUE" CDS complement(2271218..2271940) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855244, 22950025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme possibly involved in cell wall turnover" /protein_id="NP_390181.1" /db_xref="EnsemblGenomes-Gn:BSU23000" /db_xref="EnsemblGenomes-Tr:CAB14216" /db_xref="GOA:P50731" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11431" /db_xref="UniProtKB/Swiss-Prot:P50731" /translation="MTNMSRVERRKAQNLYEDQNAALADDYVDDGESLPTRQSVKNQR EQKKKQGKTKTPLFTVLAVIFVFVPVIVLVTLFYLKSHPDNHDDYEDVFIDSSQSKYE VVPKSEDKNDTADTKETALQKESKKEPEDSKPKEQTAADKKQTAVAEKEDSPNKEEAT AAAASSSQSTVQQQEQPAEPVQNVPNRVVKHTVQKKETLYRISMKYYKSRTGEEKIRA YNHLNGNDVYTGQVLDIPLMDE*" gene complement(2271218..2271940) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" downshifts complement(2271499) /Source="Nicolas_upshifts" /id="D1204" /incds=1 /nref=4 /ntot=93 /MaxReadThrough="4.30678" /MaxDrop="3.33147" /score="6.86206051" /energy="-7.5" /TU="U1799,U1801" /idTUdmin="U1799" /TUdmin="-748" /isTUend="FALSE" CDS complement(2271891..2272460) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390182.1" /db_xref="EnsemblGenomes-Gn:BSU23010" /db_xref="EnsemblGenomes-Tr:CAB14217" /db_xref="GOA:P50730" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG11430" /db_xref="UniProtKB/Swiss-Prot:P50730" /translation="MTQLLIIFAAAAAGLFFFEDVRDVLKLWDIRDMRIIWYGVSIAV IVILADMAVMKWFPSHLYDDGGINKKIFSKRSIPHIIFLTLLIAFAEEMLFRGVLQTH IGLWTASLIFAALHFRYLSKWLLFIMVTAISFLLGLMYEWTGNLFVPMTAHFIIDAVF ACQIRFEHVRRDKHDEHVESREKKSPESL*" gene complement(2271891..2272460) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" promotor_-10 complement(2272209..2272227) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2272225) /Source="Nicolas_upshifts" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" promotor_-35 complement(2272242..2272248) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2272479..2273225 /Source="Nicolas_S_feature" /locus_tag="new_2406881_2407627" /HighExp="S6, S8, S7, C30, BT, S5, C90, Pyr, BC, Sw" /AntisenseName="recQ" /AntisenseCor="-0.47918253719211501" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S871" CDS complement(2272520..2274010) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16385024, 25246477, 26001966, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385024, 25246477, 26001966, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_390183.1" /db_xref="EnsemblGenomes-Gn:BSU23020" /db_xref="EnsemblGenomes-Tr:CAB14218" /db_xref="GOA:P50729" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002464" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11407" /db_xref="UniProtKB/Swiss-Prot:P50729" /translation="MTKLQQTLYQFFGFTSFKKGQQDIIESILSGKDTIAMLPTGGGK SLCYQLPGYMLDGMVLIVSPLLSLMEDQVQQLKARGEKRAAALNSMLNRQERQFVLEH IHRYKFLYLSPEALQSPYVLEKLKSVPISLFVIDEAHCISEWGHDFRPDYSKLGQLRK KLGHPPVLALTATATKETLQDVMNLLELQHAVRHLNSVNRPNIALRVENAADTAEKID RVIQLVENLQGPGIVYCPTRKWAKELAGEIKSKTSSRADFYHGGLESGDRILIQQQFI HNQLDVICCTNAFGMGVDKPDIRYVIHFHLPQTAEAFMQEIGRAGRDGKPSVSILLRA PGDFELQEQIIQMESVTAEEIADVIRVLEKTEERDERRLRDVLLQYGVGETQARMMIH LFMQGKTSVELMKKEISYRMELKLEKMHRVSFLLQRDGCLRQALLTYFDESYEPDDGN LPCCSHCGFDLSLYEQKGERSKMAPLDSWSSELHRIFSLQTVGELN*" gene complement(2272520..2274010) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" CDS complement(2274003..2275061) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" /experiment="publication(s) with functional evidences, PMID:21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21170359; Product type f: factor" /codon_start=1 /transl_table=11 /product="subunit of the platform for genome maintenance machinery" /protein_id="NP_390184.1" /db_xref="EnsemblGenomes-Gn:BSU23030" /db_xref="EnsemblGenomes-Tr:CAB14219" /db_xref="InterPro:IPR008308" /db_xref="InterPro:IPR029491" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11429" /db_xref="UniProtKB/Swiss-Prot:P50728" /translation="MSLNYFDIMVLDCLCKINGERSGSAVFHLFKGKRSSQTIQDAGL FQTAKYFGMAAKCSRSDISASLDKLEKHSYLAPMSESDTYKVTASGAAVLRHALSERP WPVHCHGAHYQQAAGVLWKRLSLLVQVLSHKQQGSRQYIPVTKDHKTLHWVKKYLSRH TDHIEMAKSLFAMLEAHLKKIENKAAQIFVYSLTSHHRIGYTSRQLADTLKEDEWYVY IMFWASVHYFIHSLPECEDALLKDLLSDVHLDNALTESTRKTWQMVKQGFPIQRIAEI RKLKTATIEDHIVEISLHEPAFMINDYVSAEDQLQIAEFAKRMRTNKIKQIRDGLEQR FSYFQIRLALTKQVQQYD*" gene complement(2274003..2275061) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" promotor_-35 2274351..2274360 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2274371..2275161 /Source="Nicolas_S_feature" /locus_tag="new_2408773_2409563" /HighExp="S8, S6, S7, S5, BT, B36, Pyr, G/S, B60, nit" /AntisenseName="ypbB" /AntisenseCor="-0.76734368116597995" /AntisenseRegPval="-52.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S872" upshifts 2274371 /Source="Nicolas_upshifts" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" promotor_-10 2274373..2274392 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2275102..2275121) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2275125) /Source="Nicolas_upshifts" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" promotor_-35 complement(2275133..2275140) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2275139..2275145 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-35" promotor_-10 2275159..2275178 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-10" S_feature 2275163..2275232 /Source="Nicolas_S_feature" /locus_tag="new_2409565_2409634" /HighExp="S6, S8, S7, S5, BT, B36, C30, Pyr, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="0.991, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S873" upshifts 2275163 /Source="Nicolas_upshifts" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" promotor_-35 2275212..2275219 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2275234..2275326 /Source="Nicolas_S_feature" /locus_tag="new_2409636_2409728" /HighExp="LPhT, LBGstat, HPh, C90, LBGtran, C30, Lbtran, Cold, LPh, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.996" /TUlongSig="SigB" /TUlongPSig="0.991" /label="S874" promotor_-10 2275234..2275253 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2275234 /Source="Nicolas_upshifts" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" CDS 2275327..2275575 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12538057, 21665975" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12538057, 21665975; Product type c: carrier" /codon_start=1 /transl_table=11 /product="ferredoxin" /protein_id="NP_390185.1" /db_xref="EnsemblGenomes-Gn:BSU23040" /db_xref="EnsemblGenomes-Tr:CAB14220" /db_xref="GOA:P50727" /db_xref="InterPro:IPR001080" /db_xref="InterPro:IPR017896" /db_xref="SubtiList:BG11388" /db_xref="UniProtKB/Swiss-Prot:P50727" /translation="MAKYTIVDKDTCIACGACGAAAPDIYDYDDEGIAFVTLDENKGV VEVPEVLEEDMIDAFEGCPTDSIKVADEPFEGDPLKFE*" gene 2275327..2275575 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" downshifts 2275559 /Source="Nicolas_upshifts" /id="D1205" /incds=0 /nref=221 /ntot=291 /MaxReadThrough="3.16016" /MaxDrop="8.38074" /score="34.9672707" /energy="-9.9" /TU="U1803" /idTUdmin="U1800" /TUdmin=0 /isTUend="TRUE" CDS complement(2275615..2276187) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12456892, 15849754, 16850406, 17693491, 25438558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15849754, 16850406, 17693491, 25438558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="FMN permease" /protein_id="NP_390186.1" /db_xref="EnsemblGenomes-Gn:BSU23050" /db_xref="EnsemblGenomes-Tr:CAB14237" /db_xref="GOA:P50726" /db_xref="InterPro:IPR024529" /db_xref="InterPro:IPR025720" /db_xref="SubtiList:BG11428" /db_xref="UniProtKB/Swiss-Prot:P50726" /translation="MKVKKLVVVSMLSSIAFVLMLLNFPFPGLPDYLKIDFSDVPAII AILIYGPLAGIAVEAIKNVLQYIIQGSMAGVPVGQVANFIAGTLFILPTAFLFKKLNS AKGLAVSLLLGTAAMTILMSILNYVLILPAYTWFLHSPALSDSALKTAVVAGILPFNM IKGIVITVVFSLIFIKLKPWIEQQRSAHIH*" gene complement(2275615..2276187) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" downshifts complement(2275635) /Source="Nicolas_upshifts" /id="D1206" /incds=0 /nref=103 /ntot=231 /MaxReadThrough="2.60651" /MaxDrop="4.95518" /score="35.0684207" /energy="-9.9" /TU="NA" /idTUdmin="U1804" /TUdmin=0 /isTUend="TRUE" misc_RNA complement(2276179..2276486) /gene="fswB" /locus_tag="BSU_misc_RNA_78" /product="flavin mononucleotide riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508; Product type n: RNA" gene complement(2276179..2276486) /gene="fswB" /locus_tag="BSU_misc_RNA_78" S_feature complement(2276188..2276292) /Source="Nicolas_S_feature" /locus_tag="new_2410590_2410694_c" /HighExp="S1, LPhT, M9-stat, B60, Heat, T0.30H, Gly, S5, BC, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S875" promotor_-10 complement(2276485..2276504) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2276501) /Source="Nicolas_upshifts" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" promotor_-35 complement(2276518..2276524) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2276613..2276620 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2276631 /Source="Nicolas_upshifts" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" promotor_-10 2276635..2276654 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2276684..2278261 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" /EC_number="1.1.1.95" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoglycerate dehydrogenase" /protein_id="NP_390188.2" /db_xref="EnsemblGenomes-Gn:BSU23070" /db_xref="EnsemblGenomes-Tr:CAB14239" /db_xref="GOA:P35136" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR006236" /db_xref="InterPro:IPR029009" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10509" /db_xref="UniProtKB/Swiss-Prot:P35136" /translation="MFRVLVSDKMSNDGLQPLIESDFIEIVQKNVADAEDELHTFDAL LVRSATKVTEDLFNKMTSLKIVGRAGVGVDNIDIDEATKHGVIVINAPNGNTISTAEH TFAMISSLMRHIPQANISVKSREWNRTAYVGSELYGKTLGIVGLGRIGSEIAQRARAF GMTVHVFDPFLTEERAKKIGVNSRTFEEVLESADIITVHTPLTKETKGLLNKETIAKT KKGVRLINCARGGIIDEAALLEALENGHVAGAALDVFEVEPPVDNKLVDHPLVIATPH LGASTKEAQLNVAAQVSEEVLQFAKGLPVMSAINLPAMTKDEFAKIKPYHQIAGKIGS LVSQCMKEPVQDVAIQYEGTIAKLETSFITKALLSGFLKPRVDSTVNEVNAGGVAKER GISFSEKISSSESGYDNCISVKVTGDRSTFTVTATYIPHFGERIVEINGFNIDFYPTG HLVYIQHQDTTGVIGRVGRILGDNDINIATMQVGRKEKGGEAIMMLSFDRHLEDKIVK ELTNVPDIVSVKLIDLP*" gene 2276684..2278261 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" downshifts 2278243 /Source="Nicolas_upshifts" /id="D1207" /incds=0 /nref=246 /ntot=311 /MaxReadThrough="3.23011" /MaxDrop="8.29454" /score="32.0086708" /energy="-10.2" /TU="U1805" /idTUdmin="U1805" /TUdmin="-198" /isTUend="FALSE" CDS complement(2278304..2279071) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6442253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6442253; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase" /protein_id="NP_390189.1" /db_xref="EnsemblGenomes-Gn:BSU23080" /db_xref="EnsemblGenomes-Tr:CAB14240" /db_xref="GOA:P35146" /db_xref="InterPro:IPR001381" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018508" /db_xref="SubtiList:BG10538" /db_xref="UniProtKB/Swiss-Prot:P35146" /translation="MNVLTIKGVSIGEGMPKIIIPLMGKTEKQILNEAEAVKLLNPDI VEWRVDVFEKANDREAVTKLISKLRKSLEDKLFLFTFRTHKEGGSMEMDESSYLALLE SAIQTKDIDLIDIELFSGDANVKALVSLAEENNVYVVMSNHDFEKTPVKDEIISRLRK MQDLGAHIPKMAVMPNDTGDLLTLLDATYTMKTIYADRPIITMSMAATGLISRLSGEV FGSACTFGAGEEASAPGQIPVSELRSVLDILHKNTRG*" gene complement(2278304..2279071) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" downshifts complement(2278319) /Source="Nicolas_upshifts" /id="D1208" /incds=0 /nref=152 /ntot=231 /MaxReadThrough="2.53428" /MaxDrop="5.12103" /score="24.3727755" /energy="-10.2" /TU="NA" /idTUdmin="U1806" /TUdmin=0 /isTUend="TRUE" S_feature 2278573..2279185 /Source="Nicolas_S_feature" /locus_tag="new_2412975_2413587" /HighExp="B36, C30, LoTm, B60, C90, HiOs, BI, Sw, T1.0H, BT" /AntisenseName="aroC" /AntisenseCor="4.7354591214804703E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S876" promotor_-10 complement(2279098..2279117) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2279111) /Source="Nicolas_upshifts" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" promotor_-35 complement(2279132..2279135) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2279145 /Source="Nicolas_upshifts" /id="D1209" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="2.02363" /MaxDrop="5.64228" /score="10.7892325" /energy="-8.5" /TU="NA" /idTUdmin="U1805" /TUdmin=704 /isTUend="FALSE" CDS complement(2279183..2280289) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9139908, 9393439, 10712692, 14762009, 16306698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139908, 9393439, 10712692, 14762009, 16306698; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma(X) activity" /protein_id="NP_390190.2" /db_xref="EnsemblGenomes-Gn:BSU23090" /db_xref="EnsemblGenomes-Tr:CAB14241" /db_xref="GOA:P35166" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10537" /db_xref="UniProtKB/Swiss-Prot:P35166" /translation="MMKSEWNEEQIKELLSQLPAVKDHRSPQDIYKRLTMAKRKNKPA VRWIGPACAAAIAVYIAFIISPHFFDQAQPQQKEASQENAVTKTETEDSPKAASSLDQ TSFVVPEKEQDNYITVAVADADTSAIIPVSIQKTNADQTIQDMLFESSELGILDHAIT IPTFIDEVEIKEKPKQKELSIRVHQPATAFSIKDDTLLKKLLKESLKWSPYEKVKFLS DQNETGVRIGSYGTFTEISIPKQSKRSYYLYQNKQGQDFLVPSNHSFDTVKEAIKEME SSSQEDTTPLIQAGAVQSVTKKQKHLYIRFSKESEVDDSIAGILMIEGLLLTAKEFGF TEVTFTETRTKKIGKYDISDAIPVPAAPNPISLN*" gene complement(2279183..2280289) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" downshifts complement(2279200) /Source="Nicolas_upshifts" /id="D1210" /incds=0 /nref=155 /ntot=242 /MaxReadThrough="3.84557" /MaxDrop="5.30684" /score="7.9467954" /energy="-6.7" /TU="U1809" /idTUdmin="U1806" /TUdmin="-881" /isTUend="FALSE" CDS complement(2280225..2280809) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9636707, 11222589, 12399481, 14762009, 19767430, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9636707, 11222589, 12399481, 14762009, 19767430, 27965645; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor sigma(X)" /protein_id="NP_390191.2" /db_xref="EnsemblGenomes-Gn:BSU23100" /db_xref="EnsemblGenomes-Tr:CAB14242" /db_xref="GOA:P35165" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10536" /db_xref="UniProtKB/Swiss-Prot:P35165" /translation="MEETFQLLYDTYHQDLYQFLFYMVKDKNQTEDLLQEVYIRVLNS YHTFEGRSSEKTWLLSIARHVAIDWFRKQQTIRQRILGTFDWDTQDVRDQQLLPDELA VQHENVREIYAALDQCTIDQRAVIILRFIQGYSIQETAKALRFSESKVKTTQHRGLKV LRKHMELLREELMDDEVRMERRTDKGVVKSTSGS*" gene complement(2280225..2280809) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" promotor_-35 2280603..2280608 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2280619 /Source="Nicolas_upshifts" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2280623..2280627 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2280760..2280765 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2280777 /Source="Nicolas_upshifts" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" promotor_-10 2280781..2280799 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2280817 /Source="Nicolas_upshifts" /id="D1211" /incds=0 /nref=8 /ntot=81 /MaxReadThrough="5.89234" /MaxDrop="4.38483" /score="6.57298987" /energy="-13.5" /TU="U1808" /idTUdmin="U1807" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2280858..2280877) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2280862..2280969 /Source="Nicolas_S_feature" /locus_tag="new_2415264_2415371" /HighExp="S4, S8, S6, S7, C30, S3, LoTm, B60, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S877" upshifts complement(2280866) /Source="Nicolas_upshifts" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" promotor_-35 complement(2280890..2280897) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2280925 /Source="Nicolas_upshifts" /id="D1212" /incds=0 /nref=12 /ntot=64 /MaxReadThrough="2.08559" /MaxDrop="4.36303" /score="6.57298987" /energy="-13.5" /TU="NA" /idTUdmin="U1808" /TUdmin="-2" /isTUend="TRUE" S_feature complement(2280954..2281012) /Source="Nicolas_S_feature" /locus_tag="new_2415356_2415414_c" /HighExp="Lbstat, BI, nit, S0, M40t90, Lbtran, M0t90, G135, Sw, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S878" downshifts complement(2280985) /Source="Nicolas_upshifts" /id="D1213" /incds=0 /nref=156 /ntot=252 /MaxReadThrough="2.62215" /MaxDrop="6.99198" /score="33.3049318" /energy="-13.5" /TU="NA" /idTUdmin="U1810" /TUdmin="-4" /isTUend="TRUE" CDS complement(2281013..2282782) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase (ResD / ResE)" /protein_id="NP_390192.1" /db_xref="EnsemblGenomes-Gn:BSU23110" /db_xref="EnsemblGenomes-Tr:CAB14243" /db_xref="GOA:P35164" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:4ZR7" /db_xref="SubtiList:BG10535" /db_xref="UniProtKB/Swiss-Prot:P35164" /translation="MKFWKSVVGKLWFTILSLVLIVLFILTVLLLEFIENYHVEEAEN DLTQLANKVAVILENHEDQALARSITWELADNLTSIAIIQDEKNHWYSPNDKNRLSSI TVEQIQHDKDLNKALKDHKKVSKRTGLSDTDTDNERLIVGVPYEKDGKKGMVFLSQSL LAVKDTTKHTTRYIFLAAGIAIVLTTFFAFFLSSRVTYPLRKMREGAQDLAKGKFDTK IPILTQDEIGELATAFNQMGRQLNFHINALNQEKEQLSNILSSMADGVITINIDGTIL VTNPPAERFLQAWYYEQNMNIKEGDNLPPEAKELFQNAVSTEKEQMIEMTLQGRSWVL LMSPLYAESHVRGAVAVLRDMTEERRLDKLREDFIANVSHELRTPISMLQGYSEAIVD DIASSEEDRKEIAQIIYDESLRMGRLVNDLLDLARMESGHTGLHYEKINVNEFLEKII RKFSGVAKEKNIALDHDISLTEEEFMFDEDKMEQVFTNLIDNALRHTSAGGSVSISVH SVKDGLKIDIKDSGSGIPEEDLPFIFERFYKADKARTRGRAGTGLGLAIVKNIVEAHN GSITVHSRIDKGTTFSFYIPTKR*" gene complement(2281013..2282782) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" downshifts complement(2281069) /Source="Nicolas_upshifts" /id="D1214" /incds=0 /nref=5 /ntot=13 /MaxReadThrough="7.56028" /MaxDrop="3.58685" /score="33.3049318" /energy="-13.5" /TU="U1810,U1811,U1812" /idTUdmin="U1810" /TUdmin="-88" /isTUend="FALSE" CDS complement(2282779..2283501) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator (ResD / ResE)" /protein_id="NP_390193.2" /db_xref="EnsemblGenomes-Gn:BSU23120" /db_xref="EnsemblGenomes-Tr:CAB14244" /db_xref="GOA:P35163" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10534" /db_xref="UniProtKB/Swiss-Prot:P35163" /translation="MDQTNETKILVVDDEARIRRLLRMYLERENYAIDEAENGDEAIA KGLEANYDLILLDLMMPGTDGIEVCRQIREKKATPIIMLTAKGEEANRVQGFEAGTDD YIVKPFSPREVVLRVKALLRRASQTSYFNANTPTKNVLVFSHLSIDHDAHRVTADGTE VSLTPKEYELLYFLAKTPDKVYDREKLLKEVWQYEFFGDLRTVDTHVKRLREKLNKVS PEAAKKIVTVWGVGYKFEVGAE*" gene complement(2282779..2283501) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" S_feature complement(2283502..2283581) /Source="Nicolas_S_feature" /locus_tag="new_2417904_2417983_c" /HighExp="Lbstat, M0t90, ferm, M40t90, S2, S0, nit, M40t45, BI, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S879" CDS complement(2283582..2284757) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10844653, 12682299, 15849754, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844653, 12682299, 15849754, 16850406, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390194.2" /db_xref="EnsemblGenomes-Gn:BSU23130" /db_xref="EnsemblGenomes-Tr:CAB14245" /db_xref="GOA:P35162" /db_xref="InterPro:IPR002541" /db_xref="InterPro:IPR017562" /db_xref="SubtiList:BG10533" /db_xref="UniProtKB/Swiss-Prot:P35162" /translation="MAELSGNFLYAAFLVYLIAVPIFGGAIRGNKDKKGRPNRWANIG ITLSIVGFFCHLGYFITRWAASGHAPVSNMFEFTTAFGMMLVLAFIILYFLYRLPSLG LFTLSIALLLIAYASMFPTDISPLIPSLQSNWLYIHVTTAALGQAILAISFVAGVIFL LKHVDQTKPSKKTFWLEAIMFILVTTVAFIAITSAFRLAGYEAEFNWVDKSKEKSVMV YEMPALVGPHQGELLTEGRMEPLVDLPALFSGRKVNTVIWSFGAGLVLYGALRLIIRK RISALLHPLVKNVNLDLVDEVGYRAVSIGFPIFTLGALIFAMIWAQLAWTRFWGWDPK EVWALITFLFYAAYLHLRLSRGWHGEKSAWLAVIGFAIIMFNLIFVNLVLAGLHSYA* " gene complement(2283582..2284757) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" CDS complement(2284777..2286405) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9395519, 10844653, 12682299, 16825793, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9395519, 10844653, 12682299, 16825793, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390195.1" /db_xref="EnsemblGenomes-Gn:BSU23140" /db_xref="EnsemblGenomes-Tr:CAB14246" /db_xref="GOA:P35161" /db_xref="InterPro:IPR007816" /db_xref="SubtiList:BG10532" /db_xref="UniProtKB/Swiss-Prot:P35161" /translation="MKQVKCECGHINPVGTVLCESCGRALQETQPPLADMRYDGSARR SQTYNKTIIDKIWNFFSSVKVGIWLIVITLAASAFGTIFPQEAYLPPGAQADTYYKEQ YGTFGQLYYLLGFHHLYGSWWYLLLIASIGISLVICSLDRVIPLYRALKNQGVRRSPA FLRRQRLFSETVTVLNGESKEKIVTLLKKKHYRIREKEGSILAEKGRFSRWGPYVNHI GLIIFLIGAMLRFVPGMYVDETLWVREGETAAIPGTDGKYYLKNNQFSVETYNSKTEK KVFADAIDRVGDGRVAKNFQTDAVLYKREGKIVYGEKPKLEKVTEEDIRVNQPLRFDS FSVYQVDYKENQLDQMVFQLIDKKTKKSFGSLKINLLDPDSVYDLGNGYKVEIASYLP DFYFNQDGEPSTKTKIPNNPAFVFNIITPDKPKGEKSFVAIQETIEGSGNNKYKLKFD HVETKNITGLTVRKDLTLWVLAVGGAIFMIGVIQGMYWQHRRIWLHSQDGAVMVAGHT NKNWFGLKKDLAFILADSGLTEPVDQKELIKTQK*" gene complement(2284777..2286405) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" CDS complement(2286402..2286941) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="extracytoplasmic thioredoxin involved in cytochrome c maturation (lipoprotein)" /protein_id="NP_390196.2" /db_xref="EnsemblGenomes-Gn:BSU23150" /db_xref="EnsemblGenomes-Tr:CAB14247" /db_xref="GOA:P35160" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR023555" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ST9" /db_xref="PDB:1SU9" /db_xref="PDB:2F9S" /db_xref="PDB:2H19" /db_xref="PDB:2H1A" /db_xref="PDB:2H1B" /db_xref="PDB:2H1D" /db_xref="PDB:2H1G" /db_xref="PDB:3C71" /db_xref="PDB:3C73" /db_xref="SubtiList:BG10531" /db_xref="UniProtKB/Swiss-Prot:P35160" /translation="MKKKRRLFIRTGILLVLICALGYTIYNAVFAGKESISEGSDAPN FVLEDTNGKRIELSDLKGKGVFLNFWGTWCEPCKKEFPYMANQYKHFKSQGVEIVAVN VGESKIAVHNFMKSYGVNFPVVLDTDRQVLDAYDVSPLPTTFLINPEGKVVKVVTGTM TESMIHDYMNLIKPGETSG*" gene complement(2286402..2286941) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" S_feature complement(2286942..2287035) /Source="Nicolas_S_feature" /locus_tag="new_2421344_2421437_c" /HighExp="LBGtran, LBGstat, G180, Oxctl, H2O2, G150, M0t90, G135, Paraq, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S880" CDS complement(2287036..2287770) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" /EC_number="4.2.1.70" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9888802, 24214967" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888802, 24214967; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA pseudouridine 2633 (=2605 standard) pseudouridine synthase" /protein_id="NP_390197.2" /db_xref="EnsemblGenomes-Gn:BSU23160" /db_xref="EnsemblGenomes-Tr:CAB14248" /db_xref="GOA:P35159" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10530" /db_xref="UniProtKB/Swiss-Prot:P35159" /translation="MERLQKVIAHAGVASRRKAEELIKEGKVKVNGKVVTELGVKVTG SDQIEVNGLKVEREEPVYFLLYKPRGVISAAQDDKGRKVVTDFFKNIPQRIYPIGRLD YDTSGLLLLTNDGEFANKLMHPKYEIDKTYVAKVKGIPPKELLRKLERGIRLEEGKTA PAKAKLLSLDKKKQTSIIQLTIHEGRNRQVRRMFEAIGHEVIKLKREEYAFLNLRGLH TGDARELTPHEVKRLRALADHGKNAF*" gene complement(2287036..2287770) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" promotor_-10 complement(2287779..2287798) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2287802) /Source="Nicolas_upshifts" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" promotor_-35 complement(2287813..2287817) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2287862..2288398) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390198.2" /db_xref="EnsemblGenomes-Gn:BSU23170" /db_xref="EnsemblGenomes-Tr:CAB14249" /db_xref="GOA:P35158" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10529" /db_xref="UniProtKB/Swiss-Prot:P35158" /translation="MEIINWLSLAMIPIIIAGILLYGTIKKVPTYESFVEGGKEGIEI AFSIIPYLVGMLVAITVFRSSGALDFIMDLLKPAFSAIGIPAEVVPLALIRPISGTAA LGMTTDLIAVYGPDSFIGRLASVMQGSTDTTLYVLTVYFGAVGIKKMGDALKVGLLAD LIGVVASIIIVTLLFGSA*" gene complement(2287862..2288398) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" promotor_-10 complement(2287867..2287886) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2287871) /Source="Nicolas_upshifts" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" promotor_-35 complement(2287901..2287908) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2288403..2288993) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390199.1" /db_xref="EnsemblGenomes-Gn:BSU23180" /db_xref="EnsemblGenomes-Tr:CAB14250" /db_xref="GOA:P35157" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10528" /db_xref="UniProtKB/Swiss-Prot:P35157" /translation="MVNIIWVSLTVIGLVFAMCNGTLQDVNEAVFKGAKEAITISFGL MSVLVFWLGLMKIAEQSGLLDIFSRMCRPFISKLFPDIPPDHPAMGYILSNLMANFFG LGNAATPLGIKAMEQMKKLNGNRSEASRSMITFLAVNTSCITLIPTTVIAVRMAYSSK TPTDIVGPSILATLISGIGAIIIDRYFYYRRKKKGR*" gene complement(2288403..2288993) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" CDS complement(2288981..2290129) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" /EC_number="3.4.16.4" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 8892816, 9864321, 10498740, 18266856, 19542328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 8892816, 9864321, 10498740, 18266856, 19542328; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5*) (required for spore cortex)" /protein_id="NP_390200.1" /db_xref="EnsemblGenomes-Gn:BSU23190" /db_xref="EnsemblGenomes-Tr:CAB14251" /db_xref="GOA:P35150" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR018044" /db_xref="PDB:3MFD" /db_xref="SubtiList:BG10527" /db_xref="UniProtKB/Swiss-Prot:P35150" /translation="MRIFKKAVFVIMISFLIATVNVNTAHAAIDVSAKSAIIIDGASG RVLYAKDEHQKRRIASITKIMTAVLAIESGKMDQTVTVSANAVRTEGSAIYLTEGQKV KLKDLVYGLMLRSGNDAAVAIAEHVGGSLDGFVYMMNQKAEQLGMKNTRFQNPHGLDD HENHYSTAYDMAILTKYAMKLKDYQKISGTKIYKAETMESVWKNKNKLLTMLYPYSTG GKTGYTKLAKRTLVSTASKDGIDLIAVTINDPNDWDDHMKMFNYVFEHYQTYLIAKKG DIPKLKGTFYESKAFIKRDITYLLTEEEKENVKINTTLLKPKKAWEKDASKIPDIVGH MEIMFNDATIAKVPIYYENERHQKPKKQFFETFKSIFLNAAGGAKWSI*" gene complement(2288981..2290129) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" promotor_-10 complement(2290151..2290169) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2290158) /Source="Nicolas_upshifts" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" promotor_-35 complement(2290184..2290189) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2290252..2290791) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12065423" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390201.1" /db_xref="EnsemblGenomes-Gn:BSU23200" /db_xref="EnsemblGenomes-Tr:CAB14252" /db_xref="InterPro:IPR025013" /db_xref="SubtiList:BG10526" /db_xref="UniProtKB/Swiss-Prot:P35156" /translation="MKEAKCERQIHEGKIPNEMGHSIVRAQTQKTGEFLSMVVNTVND YLNQTTLESLQAELPIEKGYCCDVLSTLRRMAVFCEGGAEACRRLLMQEPFQEARAEK TLYNVYHQCIEEFFMPKKDTWCENSRASYTGVSAIEFYHAVPASLEQLLLPLSAAFLK MREELAHYEASGSSMAPIR*" gene complement(2290252..2290791) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" downshifts complement(2290265) /Source="Nicolas_upshifts" /id="D1215" /incds=0 /nref=219 /ntot=260 /MaxReadThrough="1.63638" /MaxDrop="8.00748" /score="36.7302977" /energy="-12.2" /TU="NA" /idTUdmin="U1813" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2290800..2290817) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2290815) /Source="Nicolas_upshifts" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" promotor_-35 complement(2290832..2290837) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2290846..2291439) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation factor" /protein_id="NP_390202.1" /db_xref="EnsemblGenomes-Gn:BSU23210" /db_xref="EnsemblGenomes-Tr:CAB14253" /db_xref="GOA:P35155" /db_xref="InterPro:IPR005234" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10525" /db_xref="UniProtKB/Swiss-Prot:P35155" /translation="MGLDIVNWKAIVEALLYAAGDEGLTKKQLLTVLEIEEPELNTIM ADVADEYRGDTRGIELIEYADTYMLSTKKDFAPYLKKLIEVPSKGLSQASLEVLAIVS YKQPITRAEIEEIRGVKSERILHSLVAKALLCEVGRADGPGRAILYGTTPTFLEQFGL KTLDELPPLPENAEEDVLQEEADLFFENFNQTFEDIK*" gene complement(2290846..2291439) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" CDS complement(2291429..2292184) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and partitioning factor" /protein_id="NP_390203.1" /db_xref="EnsemblGenomes-Gn:BSU23220" /db_xref="EnsemblGenomes-Tr:CAB14254" /db_xref="GOA:P35154" /db_xref="InterPro:IPR003768" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG10524" /db_xref="UniProtKB/Swiss-Prot:P35154" /translation="MEEYQVKIDTFEGPLDLLLHLINRLEIDIYDIPVAKITEQYLLY VHTMRVLELDIASEYLVMAATLLSIKSRMLLPKQEEELFEDELLEEEDPREELIEKLI EYRKYKDAAKDLKEREEERQKSFTKPPSDLSEYAKEVKQSEQKLSVTVYDMIGAFQKV LKRKKINRPMETTITRQDIPIEARMNEIVHSLKSRGTRINFMDLFPYEQKEHLVVTFL AVLELMKNQLVLIEQEHNFSDIYITGSESIHGA*" gene complement(2291429..2292184) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" promotor_-35 2292028..2292037 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2292050..2292069 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2292059 /Source="Nicolas_upshifts" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2292230..2292249) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2292245) /Source="Nicolas_upshifts" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" promotor_-35 complement(2292263..2292270) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2292410..2292417 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2292428..2292447 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2292433 /Source="Nicolas_upshifts" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" CDS 2292465..2292989 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390204.1" /db_xref="EnsemblGenomes-Gn:BSU23230" /db_xref="EnsemblGenomes-Tr:CAB14255" /db_xref="InterPro:IPR005500" /db_xref="InterPro:IPR023203" /db_xref="SubtiList:BG10523" /db_xref="UniProtKB/Swiss-Prot:P17617" /translation="MYPKAYIDYLVEFHATRDYFECHEILEEYWKEDPPKKRKRYWVG FIQLAVALYHHRRQNTAGAKRLMANSIRILQAEHRAVEDLGLDHGRLLELMQSVYEQI ETVSAYKSIILPIKDEKLEEACRIECRKKKYTWGQPSALSNIFLIDKHRLRDRTDVIR EREKEIERRKKSRD*" gene 2292465..2292989 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" CDS complement(2293003..2293377) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15466513, 25349719; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative riboflavin synthesis-related N-acetyltransferase" /protein_id="NP_390205.1" /db_xref="EnsemblGenomes-Gn:BSU23240" /db_xref="EnsemblGenomes-Tr:CAB14256" /db_xref="GOA:P17622" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10522" /db_xref="UniProtKB/Swiss-Prot:P17622" /translation="MLIRYKKSFEKIAMGLLSFMPNEKDLKQLQQTIKDYETDTDRQL FLWKEDEDIVGAIGVEKKDSEVEIRHISVNPSHRHQGIGKQMMDALKHLFKTQVLVPN ELTQSFFERCQGQQDQDISYNN*" gene complement(2293003..2293377) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" downshifts complement(2293019) /Source="Nicolas_upshifts" /id="D1216" /incds=0 /nref=264 /ntot=275 /MaxReadThrough="1.34496" /MaxDrop="8.09525" /score="39.5464967" /energy="-14.3" /TU="NA" /idTUdmin="U1817" /TUdmin="-4" /isTUend="TRUE" promotor_-10 complement(2293439..2293458) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2293451) /Source="Nicolas_upshifts" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" promotor_-35 complement(2293470..2293477) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2293490..2293954) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" /EC_number="2.5.1.78" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3100522, 7473709, 10881048, 12456892, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3100522, 7473709, 10881048, 12456892, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6,7-dimethyl-8-ribityllumazine synthase, beta subunit" /protein_id="NP_390206.1" /db_xref="EnsemblGenomes-Gn:BSU23250" /db_xref="EnsemblGenomes-Tr:CAB14257" /db_xref="GOA:P11998" /db_xref="InterPro:IPR002180" /db_xref="InterPro:IPR034964" /db_xref="InterPro:IPR036467" /db_xref="PDB:1RVV" /db_xref="PDB:1ZIS" /db_xref="SubtiList:BG10521" /db_xref="UniProtKB/Swiss-Prot:P11998" /translation="MNIIQGNLVGTGLKIGIVVGRFNDFITSKLLSGAEDALLRHGVD TNDIDVAWVPGAFEIPFAAKKMAETKKYDAIITLGTVIRGATTHYDYVCNEAAKGIAQ AANTTGVPVIFGIVTTENIEQAIERAGTKAGNKGVDCAVSAIEMANLNRSFE*" gene complement(2293490..2293954) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" promotor_-35 2293825..2293829 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2293843..2293847 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2293846 /Source="Nicolas_upshifts" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2293987..2295183) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" /EC_number="3.5.4.25" /EC_number="4.1.99.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9297088, 9515916, 12456892, 19583770, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9297088, 9515916, 12456892, 19583770, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused 3,4-dihydroxy-2-butanone 4-phosphate synthase and GTP cyclohydrolase II" /protein_id="NP_390207.1" /db_xref="EnsemblGenomes-Gn:BSU23260" /db_xref="EnsemblGenomes-Tr:CAB14258" /db_xref="GOA:P17620" /db_xref="InterPro:IPR000422" /db_xref="InterPro:IPR000926" /db_xref="InterPro:IPR016299" /db_xref="InterPro:IPR017945" /db_xref="InterPro:IPR032677" /db_xref="InterPro:IPR036144" /db_xref="SubtiList:BG10520" /db_xref="UniProtKB/Swiss-Prot:P17620" /translation="MFHPIEEALDALKKGEVIIVVDDEDRENEGDFVALAEHATPEVI NFMATHGRGLICTPLSEEIADRLDLHPMVEHNTDSHHTAFTVSIDHRETKTGISAQER SFTVQALLDSKSVPSDFQRPGHIFPLIAKKGGVLKRAGHTEAAVDLAEACGSPGAGVI CEIMNEDGTMARVPELIEIAKKHQLKMITIKDLIQYRYNLTTLVEREVDITLPTDFGT FKVYGYTNEVDGKEHVAFVMGDVPFGEEPVLVRVHSECLTGDVFGSHRCDCGPQLHAA LNQIAAEGRGVLLYLRQEGRGIGLINKLKAYKLQEQGYDTVEANEALGFLPDLRNYGI GAQILRDLGVRNMKLLTNNPRKIAGLEGYGLSISERVPLQMEAKEHNKKYLQTKMNKL GHLLHF*" gene complement(2293987..2295183) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" CDS complement(2295198..2295845) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" /EC_number="2.5.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2106516, 12456892" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2106516, 12456892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="riboflavin synthase (alpha subunit)" /protein_id="NP_390208.1" /db_xref="EnsemblGenomes-Gn:BSU23270" /db_xref="EnsemblGenomes-Tr:CAB14259" /db_xref="GOA:P16440" /db_xref="InterPro:IPR001783" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR026017" /db_xref="SubtiList:BG10519" /db_xref="UniProtKB/Swiss-Prot:P16440" /translation="MFTGIIEETGTIESMKKAGHAMALTIKCSKILEDVHLGDSIAVN GICLTVTDFTKNQFTVDVMPETVKATSLNDLTKGSKVNLERAMAANGRFGGHFVSGHV DGTAEITRIEEKSNAVYYDLKMDPSLTKTLVLKGSITVDGVSLTIFGLTEDTVTISLI PHTISETIFSEKTIGSKVNIECDMIGKYMYRFLHKANENKTQQTITKAFLSENGF*" gene complement(2295198..2295845) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" CDS complement(2295856..2296941) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" /EC_number="1.1.1.193" /EC_number="3.5.4.26" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9068650, 12456892, 17765262, 18986985, 23385458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068650, 12456892, 17765262, 18986985, 23385458; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused diaminohydroxyphosphoribosylaminopyrimidine deaminase; 5-amino-6-(5-phosphoribosylamino) uracil reductase" /protein_id="NP_390209.1" /db_xref="EnsemblGenomes-Gn:BSU23280" /db_xref="EnsemblGenomes-Tr:CAB14260" /db_xref="GOA:P17618" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR004794" /db_xref="InterPro:IPR011549" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024072" /db_xref="PDB:2B3Z" /db_xref="PDB:2D5N" /db_xref="PDB:3EX8" /db_xref="PDB:4G3M" /db_xref="SubtiList:BG10518" /db_xref="UniProtKB/Swiss-Prot:P17618" /translation="MEEYYMKLALDLAKQGEGQTESNPLVGAVVVKDGQIVGMGAHLK YGEAHAEVHAIHMAGAHAEGADIYVTLEPCSHYGKTPPCAELIINSGIKRVFVAMRDP NPLVAGRGISMMKEAGIEVREGILADQAERLNEKFLHFMRTGLPYVTLKAAASLDGKI ATSTGDSKWITSEAARQDAQQYRKTHQSILVGVGTVKADNPSLTCRLPNVTKQPVRVI LDTVLSIPEDAKVICDQIAPTWIFTTARADEEKKKRLSAFGVNIFTLETERIQIPDVL KILAEEGIMSVYVEGGSAVHGSFVKEGCFQEIIFYFAPKLIGGTHAPSLISGEGFQSM KDVPLLQFTDITQIGRDIKLTAKPTKE*" gene complement(2295856..2296941) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" S_feature complement(2296942..2297070) /Source="Nicolas_S_feature" /locus_tag="new_2431344_2431472_c" /HighExp="T0.30H, B60, T1.30H, T2.0H, MG-0.2, T1.0H, S1, T0.0H, LPhT, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S881" misc_RNA complement(2297071..2297215) /gene="fswA" /locus_tag="BSU_misc_RNA_36" /product="flavin riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508, 17693491, 17997835" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508, 17693491, 17997835; Product type n: RNA" gene complement(2297071..2297215) /gene="fswA" /locus_tag="BSU_misc_RNA_36" promotor_-10 complement(2297232..2297251) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2297242) /Source="Nicolas_upshifts" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" promotor_-35 complement(2297266..2297273) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2297335..2297679) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390211.1" /db_xref="EnsemblGenomes-Gn:BSU23300" /db_xref="EnsemblGenomes-Tr:CAB14262" /db_xref="SubtiList:BG10516" /db_xref="UniProtKB/Swiss-Prot:P17616" /translation="MGRIKTKITILLVLLLLLAGGYMYINDIELKDVPTAIGQTLSSE EEEYTIQEYKVTKIDGSEYHGVAENGTKIIFNGKKLNQDLSDIKEGDKIKAYFSKSKR IDGLIKVAKVND*" gene complement(2297335..2297679) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" downshifts complement(2297350) /Source="Nicolas_upshifts" /id="D1217" /incds=0 /nref=78 /ntot=221 /MaxReadThrough="1.58771" /MaxDrop="5.14851" /score="20.5522057" /energy="-14.7" /TU="NA" /idTUdmin="U1820" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2297711..2297729) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2297724) /Source="Nicolas_upshifts" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" promotor_-35 2297738..2297743 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2297744..2297750) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2297758..2298680 /Source="Nicolas_S_feature" /locus_tag="new_2432160_2433082" /HighExp="S5, S4, S6, S8, S7, C30, S3, C90, BT, BC" /AntisenseName="sipS" /AntisenseCor="-0.46666993867379197" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S882" upshifts 2297758 /Source="Nicolas_upshifts" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" promotor_-10 2297759..2297777 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2297765..2297780) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2297768) /Source="Nicolas_upshifts" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" S_feature complement(2297770..2297836) /Source="Nicolas_S_feature" /locus_tag="new_2432172_2432238_c" /HighExp="Etha, T1.30H, M9-stat, T0.30H, M40t90, T2.30H, MG-0.2, MG 15, HiTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S883" promotor_-35 complement(2297793..2297802) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2297831..2297839) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2297836) /Source="Nicolas_upshifts" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" promotor_-35 complement(2297853..2297861) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2297914..2298468) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" /EC_number="3.4.21.89" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_390212.1" /db_xref="EnsemblGenomes-Gn:BSU23310" /db_xref="EnsemblGenomes-Tr:CAB14263" /db_xref="GOA:P28628" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG10515" /db_xref="UniProtKB/Swiss-Prot:P28628" /translation="MKSENVSKKKSILEWAKAIVIAVVLALLIRNFIFAPYVVDGDSM YPTLHNRERVFVNMTVKYIGEFDRGDIVVLNGDDVHYVKRIIGLPGDTVEMKNDQLYI NGKKVDEPYLAANKKRAKQDGFDHLTDDFGPVKVPDNKYFVMGDNRRNSMDSRNGLGL FTKKQIAGTSKFVFYPFNEMRKTN*" gene complement(2297914..2298468) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" downshifts complement(2297924) /Source="Nicolas_upshifts" /id="D1218" /incds=0 /nref=195 /ntot=252 /MaxReadThrough="3.6233" /MaxDrop="7.24702" /score="30.4586783" /energy="-10.9" /TU="U1824" /idTUdmin="U1825" /TUdmin="-2" /isTUend="TRUE" promotor_-10 complement(2298494..2298513) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2298512) /Source="Nicolas_upshifts" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" S_feature complement(2298514..2298913) /Source="Nicolas_S_feature" /locus_tag="new_2432916_2433315_c" /HighExp="T4.0H, T2.30H, T5.0H, T3.0H, T2.0H, T3.30H, M9-stat, C90, BC, T1.30H" /AntisenseName="ypzC" /AntisenseCor="-0.215992681600812" /AntisenseRegPval="-3.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S884" promotor_-35 complement(2298525..2298531) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2298735..2298971 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390213.1" /db_xref="EnsemblGenomes-Gn:BSU23320" /db_xref="EnsemblGenomes-Tr:CAB14264" /db_xref="SubtiList:BG13765" /db_xref="UniProtKB/Swiss-Prot:O32012" /translation="MFIYCIPLISQSMIPMALDKTINVMKVTGMFAATYFTGDNRTPF FAFIICLKSFKLENMDQPPKNKSNIFPAVEDSLL*" gene 2298735..2298971 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" CDS complement(2298914..2299120) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097757.1" /db_xref="EnsemblGenomes-Gn:BSU23328" /db_xref="EnsemblGenomes-Tr:CAX52656" /db_xref="InterPro:IPR018652" /db_xref="UniProtKB/Swiss-Prot:C0H447" /translation="MNNKGCIKCGSTEAGQKEIATTGTGLSKLFDVQHNRFLVVYCKN CGYSEFYNKESSTAGNILDLFFGG*" gene complement(2298914..2299120) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" misc_feature complement(2299153..2299172) /Source="Nicolas_upshift_promotors" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2299175) /Source="Nicolas_upshifts" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" CDS complement(2299229..2299483) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="PSEUDO:CAX52657.1" /translation="MSFLVFVLIFLFVILTRRVCKLLHFFVYYRFIPHRAEPCVLYEQ YPSDVAAGYAFGGVWLSLNVLVMELFRFSRRFTKLRNEPN*" gene complement(2299229..2299483) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /pseudo promotor_-35 2299363..2299372 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2299374..2299763) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15849754, 16850406" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="SubtiList:BG10514" /translation="MSYWIGYRLGPAAIQKAFASRGVLLAVIVLTFFWTVFRGQDRKI ELSFLFFLVIGGELYEEGIRRLFHSLHPVHAPLESHVLYPFPSEQTLTAFVIFGFCAY LFVRHSHKTRLQTVAFFCLLSFYSSSG*" gene complement(2299374..2299763) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /pseudo S_feature 2299386..2300457 /Source="Nicolas_S_feature" /locus_tag="new_2433788_2434859" /HighExp="S6, S8, S7, BT, S5, B36, S4, Pyr, G/S, C30" /AntisenseName="ypuC" /AntisenseCor="0.37168085148262697" /AntisenseRegPval="-9.5" /CDS_PredictionProba="0.69113899999999995" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S885" promotor_-10 2299386..2299405 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2299386 /Source="Nicolas_upshifts" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" CDS complement(2299741..2299944) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390215.1" /db_xref="EnsemblGenomes-Gn:BSU23340" /db_xref="EnsemblGenomes-Tr:CAB14266" /db_xref="SubtiList:BG10513" /db_xref="UniProtKB/Swiss-Prot:P35151" /translation="MQVLTGLLEQYGYAVLFIVLMLELLALLGPGEFAGVLVFQEKLN WVLSMLAAGLGSCGSEHVVLDRV*" gene complement(2299741..2299944) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" CDS 2300353..2300469 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:SOX90572.1" /translation="MYMHFESAQDDPITFARKAAAAFRVVKRIDRYLGFRKL*" gene 2300353..2300469 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /pseudo downshifts 2300420 /Source="Nicolas_upshifts" /id="D1219" /incds=0 /nref=3 /ntot=18 /MaxReadThrough="-0.179729999999999" /MaxDrop="3.76747" /score="-7.5033349" /energy="-9.1" /TU="NA" /idTUdmin="U1826" /TUdmin=198 /isTUend="FALSE" promotor_-35 2300546..2300555 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2300568..2300587 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2300568 /Source="Nicolas_upshifts" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" CDS 2300610..2300822 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative germination protein" /protein_id="NP_390216.1" /db_xref="EnsemblGenomes-Gn:BSU23350" /db_xref="EnsemblGenomes-Tr:CAB14267" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13766" /db_xref="UniProtKB/Swiss-Prot:O32013" /translation="MIDYPININNVSGNSVINVGGAFMIRPLTLSKSVFGSGGLNTGI VFENNFVSKAKMINHQFTDQNVTKTF*" gene 2300610..2300822 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" downshifts 2300816 /Source="Nicolas_upshifts" /id="D1220" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="4.9048" /MaxDrop="3.6863" /score="3.56038753" /energy="-6.9" /TU="U1827" /idTUdmin="U1827" /TUdmin="-264" /isTUend="FALSE" downshifts complement(2300958) /Source="Nicolas_upshifts" /id="D1221" /incds=0 /nref=254 /ntot=263 /MaxReadThrough="2.52018" /MaxDrop="8.47213" /score="34.3429406" /energy="-12.4" /TU="NA" /idTUdmin="U1828" /TUdmin=0 /isTUend="TRUE" CDS complement(2300958..2301389) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8639516, 9063446, 9748346, 25184565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8639516, 9063446, 9748346, 25184565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-prolyl isomerase" /protein_id="NP_390217.1" /db_xref="EnsemblGenomes-Gn:BSU23360" /db_xref="EnsemblGenomes-Tr:CAB14268" /db_xref="GOA:P35137" /db_xref="InterPro:IPR002130" /db_xref="InterPro:IPR020892" /db_xref="InterPro:IPR024936" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG10512" /db_xref="UniProtKB/Swiss-Prot:P35137" /translation="MKTGYFLLEDGNKIEFELYPEAAPGTVANFEKLANEGFYDGLTF HRVIPGFVSQGGCPHGTGTGGPGYTIKCETEGNPHTHEAGALSMAHAGKDTGGSQFFI VHEPQPHLNGVHTVFGKVTSGLEFAKNMSNGDVMKEVRVEG*" gene complement(2300958..2301389) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" S_feature complement(2301390..2301476) /Source="Nicolas_S_feature" /locus_tag="new_2435792_2435878_c" /HighExp="dia5, dia15, dia0, Lbexp, LBGtran, C90, Lbtran, HPh, G180, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S886" promotor_-10 complement(2301459..2301478) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2301476) /Source="Nicolas_upshifts" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" promotor_-35 complement(2301492..2301497) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2301526..2301535 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2301545..2301642 /Source="Nicolas_S_feature" /locus_tag="new_2435947_2436044" /HighExp="Heat, Etha, Salt, dia0, HiTm, T0.30H, B60, Lbexp, T1.0H, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S887" upshifts 2301545 /Source="Nicolas_upshifts" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" promotor_-10 2301548..2301563 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2301643..2302515 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17434969, 18179421, 24706874; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390218.1" /db_xref="EnsemblGenomes-Gn:BSU23370" /db_xref="EnsemblGenomes-Tr:CAB14269" /db_xref="InterPro:IPR009343" /db_xref="SubtiList:BG10511" /db_xref="UniProtKB/Swiss-Prot:P31847" /translation="MKKIWIGMLAAAVLLLMVPKVSLADAAVGDVIVTLGADLSESDK QKVLDEMNVPDNATTVTVTNKEEHEYLGKYISNAQIGSRAISSSSITIAKKGSGLNVE THNISGITDEMYLNALMTAGVKDAKVYVTAPFEVSGTAALTGLIKAYEVSSDEAISED VKQVANQELVTTSELGDKIGNENAAALIAKIKEEFAKNGVPDNKADIEKQVDDAASDL NVTLTDSQKNQLVSLFNKMKNADIDWGQVSDQLDKAKDKITKFIESDEGKNFIQKVID FFVSIWNAIVSIFK*" gene 2301643..2302515 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" downshifts 2302422 /Source="Nicolas_upshifts" /id="D1222" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="5.9994" /MaxDrop="4.15288" /score="27.7277161" /energy="-12.7" /TU="U1829" /idTUdmin="U1829" /TUdmin="-66" /isTUend="FALSE" downshifts 2302488 /Source="Nicolas_upshifts" /id="D1223" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="1.98749" /MaxDrop="5.95835" /score="27.7277161" /energy="-12.7" /TU="NA" /idTUdmin="U1829" /TUdmin=0 /isTUend="TRUE" CDS complement(2302545..2303864) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" /EC_number="4.1.1.20" /experiment="publication(s) with functional evidences, PMID:9044297, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9044297, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-2,6-diaminopimelate decarboxylase" /protein_id="NP_390219.1" /db_xref="EnsemblGenomes-Gn:BSU23380" /db_xref="EnsemblGenomes-Tr:CAB14270" /db_xref="GOA:P23630" /db_xref="InterPro:IPR000183" /db_xref="InterPro:IPR002986" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR022643" /db_xref="InterPro:IPR022644" /db_xref="InterPro:IPR022653" /db_xref="InterPro:IPR022657" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10510" /db_xref="UniProtKB/Swiss-Prot:P23630" /translation="MFLHGTSRQNQHGHLEIGGVDALYLAEKYGTPLYVYDVALIRER AKSFKQAFISAGLKAQVAYASKAFSSVAMIQLAEEEGLSLDVVSGGELYTAVAAGFPA ERIHFHGNNKSREELRMALEHRIGCIVVDNFYEIALLEDLCKETGHSIDVLLRITPGV EAHTHDYITTGQEDSKFGFDLHNGQTERAIEQVLQSEHIQLLGVHCHIGSQIFDTAGF VLAAEKIFKKLDEWRDSYSFVSKVLNLGGGFGIRYTEDDEPLHATEYVEKIIEAVKEN ASRYGFDIPEIWIEPGRSLVGDAGTTLYTVGSQKEVPGVRQYVAVDGGMNDNIRPALY QAKYEAAAANRIGEAHDKTVSIAGKCCESGDMLIWDIDLPEVKEGDLLAVFCTGAYGY SMANNYNRIPRPAVVFVENGEAHLVVKRETYEDIVKLDLPFKTGVKQ*" gene complement(2302545..2303864) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" downshifts complement(2302565) /Source="Nicolas_upshifts" /id="D1224" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.99445" /MaxDrop="5.13504" /score="28.6775009" /energy="-12.7" /TU="NA" /idTUdmin="U1830" /TUdmin=0 /isTUend="TRUE" S_feature complement(2303865..2303929) /Source="Nicolas_S_feature" /locus_tag="new_2438267_2438331_c" /HighExp="C90, HiOs, BMM, GM 120, GM 25, MG-0.2, GM 15, GM-0.2, MG t5, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S888" promotor_-10 complement(2303925..2303944) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2303929) /Source="Nicolas_upshifts" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" promotor_-35 complement(2303959..2303966) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2303970..2305451) /gene="spoVAF" /locus_tag="BSU_23390" /old_locus_tag="BSU23390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 17573930, 24682327, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 17573930, 24682327, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AF" /protein_id="NP_390220.2" /db_xref="EnsemblGenomes-Gn:BSU23390" /db_xref="EnsemblGenomes-Tr:CAB14271" /db_xref="GOA:P31845" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10508" /db_xref="UniProtKB/Swiss-Prot:P31845" /translation="MPDHKEEKIRVYRNPAKNEEYFKNRVGMGTSYDVGVRKLTILDK EIQLYYLNGLCDTAYIIHLMRELVAINNRKEDPDELVDIVENRLLNAQVEKVKTLDET TDQVLSGLVAVIVEGAGFAFIIDVRSYPGRNPEEPDTEKVVRGARDGFVENIVVNTAL LRRRIRDERLRVKMTKVGERSKTDLSICYIEDIADPDLVEIVEKEIASIDVDGLTMAD KTVEEFIVNQSYNPFPLVRYTERPDVAANHVLEGHVIIIVDTSPSVIITPTTLFHHVQ HAEEYRQAPSVGTFLRWVRFFGILASTLFLPIWFLFVLQPDLLPDNMKFIGLNKDTHI PIILQIFLADLGIEFLRMAAIHTPTALSTAMGLIAAVLIGQIAIEVGLFSPEVILYVS LAAIGTFTTPSYELSLANKMSRLVLMILVALFHIKGLVIGFTVLIIAMASIKSLQTPY LWPLIPFNGKALWQVLVRTAKPGAKVRPSIVHPKNRLRQPTNS*" gene complement(2303970..2305451) /gene="spoVAF" /locus_tag="BSU_23390" /old_locus_tag="BSU23390" misc_feature complement(2304676..2304695) /Source="Nicolas_upshift_promotors" /id="U1831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95004995004995" /psig="0.998001998001998" /xcortree=2143 /SigmaFactorBS="tatacagaaagaccggatgtggccgcaaatcatgttctagaa ggcCATGTTATCATTATAGTGGAcacatcgccgagtgtgatcattaccccgacgactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2304680) /Source="Nicolas_upshifts" /id="U1831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95004995004995" /psig="0.998001998001998" /xcortree=2143 /SigmaFactorBS="tatacagaaagaccggatgtggccgcaaatcatgttctagaa ggcCATGTTATCATTATAGTGGAcacatcgccgagtgtgatcattaccccgacgactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2305402..2306013) /gene="spoVAEA" /locus_tag="BSU_23401" /old_locus_tag="BSU23401" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 17573930, 24682327, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 17573930, 24682327, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation germinant protein" /protein_id="YP_003097758.1" /db_xref="EnsemblGenomes-Gn:BSU23401" /db_xref="EnsemblGenomes-Tr:CAX52658" /db_xref="GOA:P40870" /db_xref="InterPro:IPR025914" /db_xref="UniProtKB/Swiss-Prot:P40870" /translation="MTTKRKVILVTDGDVYAAKTIEYAASKVGGRCISQSKGNPSTRS GAELVKLIASAPYDPVFVMFDDSGLQGEGPGEAALTYVATHPSIEVLGVIAVASKTHQ AEWTRVDVSIDRNGEITEYGVDKVGEREFDDHRMSGDTVYCLDKLDLPLIVGIGDIGK MGRKDDISKGSPITMKAVEFILERSGYHAGPQGRENSGLSESS*" gene complement(2305402..2306013) /gene="spoVAEA" /locus_tag="BSU_23401" /old_locus_tag="BSU23401" CDS complement(2306021..2306371) /gene="spoVAEB" /locus_tag="BSU_23402" /old_locus_tag="BSU23402" /experiment="publication(s) with functional evidences, PMID:17573930, 26604257, 27105070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17573930, 26604257, 27105070; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germinant protein" /protein_id="YP_003097759.1" /db_xref="EnsemblGenomes-Gn:BSU23402" /db_xref="EnsemblGenomes-Tr:CAX52659" /db_xref="GOA:C0H450" /db_xref="InterPro:IPR005562" /db_xref="InterPro:IPR014204" /db_xref="UniProtKB/Swiss-Prot:C0H450" /translation="MDYLLAFVCGGAICIVGQLLLDIFKLTPAHVMTSFVVIGAILDG FGIYDKFIEFAGGGATVPIVSFGHSLLHGAMHQAHIHGFIGIGMGIFELTSAGISAAI LFAFIVAVIFKPKG*" gene complement(2306021..2306371) /gene="spoVAEB" /locus_tag="BSU_23402" /old_locus_tag="BSU23402" CDS complement(2306373..2307389) /gene="spoVAD" /locus_tag="BSU_23410" /old_locus_tag="BSU23410" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 22328679, 26604257, 27105070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 22328679, 26604257, 27105070; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AD (uptake of pyridine-2,6-dicarboxylic acid)" /protein_id="NP_390222.1" /db_xref="EnsemblGenomes-Gn:BSU23410" /db_xref="EnsemblGenomes-Tr:CAB14273" /db_xref="GOA:P40869" /db_xref="InterPro:IPR010894" /db_xref="InterPro:IPR016039" /db_xref="PDB:3LM6" /db_xref="SubtiList:BG10895" /db_xref="UniProtKB/Swiss-Prot:P40869" /translation="MKLTGKQTWVFEHPIFVNSAGTAAGPKEKDGPLGSLFDKTYDEM HCNQKSWEMAERQLMEDAVNVALQKNNLTKDDIDLLLAGDLLNQNVTANYVARHLKIP FLCMFGACSTSMETVAVASALVDGGFAKRALAATSSHNATAERQFRYPTEYGGQKPDT ATSTVTGSGAVVISQTPGDIQITSATVGKVSDLGITDPFDMGSAMAPAAADTIKQHFK DLNRTADDYDLILTGDLSGVGSPIVKDILKEDGYPVGTKHDDCGLLIYTPDQQVFAGG SGCACSAVVTYSHIFKQLREGKLNRVFVVATGALLSPTMIQQKETIPTIAHGVVFERA GGAS*" gene complement(2306373..2307389) /gene="spoVAD" /locus_tag="BSU_23410" /old_locus_tag="BSU23410" promotor_-35 2306869..2306876 /Source="Nicolas_upshift_promotors" /id="U1832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.987012987012987" /xcortree=627 /SigmaFactorBS="tatcacccggtgtctgaCTGATGACaactgcaccgcttCCGG TTACAGTGGAGGTAGCagtgtccggtttttggcctccgtattctgtcggatagcgaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2306890..2306909 /Source="Nicolas_upshift_promotors" /id="U1832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.987012987012987" /xcortree=627 /SigmaFactorBS="tatcacccggtgtctgaCTGATGACaactgcaccgcttCCGG TTACAGTGGAGGTAGCagtgtccggtttttggcctccgtattctgtcggatagcgaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2306912 /Source="Nicolas_upshifts" /id="U1832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.987012987012987" /xcortree=627 /SigmaFactorBS="tatcacccggtgtctgaCTGATGACaactgcaccgcttCCGG TTACAGTGGAGGTAGCagtgtccggtttttggcctccgtattctgtcggatagcgaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2307402..2307854) /gene="spoVAC" /locus_tag="BSU_23420" /old_locus_tag="BSU23420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16077113, 16850406, 24666282, 26604257, 27105070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16077113, 16850406, 24666282, 26604257, 27105070; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="mechanosensitive channel; stage V sporulation protein AC" /protein_id="NP_390223.1" /db_xref="EnsemblGenomes-Gn:BSU23420" /db_xref="EnsemblGenomes-Tr:CAB14274" /db_xref="GOA:P40868" /db_xref="InterPro:IPR005562" /db_xref="InterPro:IPR014203" /db_xref="SubtiList:BG10894" /db_xref="UniProtKB/Swiss-Prot:P40868" /translation="MTNIKENYKSKVKTYQPKPPYVWNCVKAFLVGGLICAIGQGLQN FYIHFFDFNEKTAGNPTAATLILISALLTGFGIYDRIGQFAGAGSAVPVTGFANSMAS AALEYKSEGLVLGVATNMFKLAGNVIVFGVVAAYIVGMIRFAFEKLMS*" gene complement(2307402..2307854) /gene="spoVAC" /locus_tag="BSU_23420" /old_locus_tag="BSU23420" CDS complement(2307867..2308292) /gene="spoVAB" /locus_tag="BSU_23430" /old_locus_tag="BSU23430" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16077113, 16850406, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16077113, 16850406, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AB" /protein_id="NP_390224.1" /db_xref="EnsemblGenomes-Gn:BSU23430" /db_xref="EnsemblGenomes-Tr:CAB14275" /db_xref="GOA:P40867" /db_xref="InterPro:IPR020144" /db_xref="SubtiList:BG10893" /db_xref="UniProtKB/Swiss-Prot:P40867" /translation="MIVSVLFIIFVGLGGGITVGAGFVAFLTVMGIIPRLMQLTKTMR FVQAYEAAVILGAVCGGWETLHMNHLYLTKWIAVPVGLLAGLFVGMLAAALTEVLNVL PILAKRIGLRSKIIILLMAIVIGKIAGSLFHWLYFIDHS*" gene complement(2307867..2308292) /gene="spoVAB" /locus_tag="BSU_23430" /old_locus_tag="BSU23430" CDS complement(2308282..2308902) /gene="spoVAA" /locus_tag="BSU_23440" /old_locus_tag="BSU23440" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:3114420, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3114420, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AA" /protein_id="NP_390225.2" /db_xref="EnsemblGenomes-Gn:BSU23440" /db_xref="EnsemblGenomes-Tr:CAB14276" /db_xref="GOA:P40866" /db_xref="InterPro:IPR021997" /db_xref="SubtiList:BG10892" /db_xref="UniProtKB/Swiss-Prot:P40866" /translation="MERRIFIRLRHRVLAHPGDIITVGDAAQIEGQLQLKKKLSAMPL YQVSEKDKNIVILDIIQVLRAIHLQDPTIDVQTVGGAETIVEIQYRKRNLSTVLFIGV WLLLFIGSCLAIMNFHEDVSMRDVHIALYEIITGERNDYPYLLQIPYSIGLGLGMIVF FNHIFKKRLNEEPSPLEVEMFNYQLDLDQYVAMHENQETIKDLHDR*" gene complement(2308282..2308902) /gene="spoVAA" /locus_tag="BSU_23440" /old_locus_tag="BSU23440" promotor_-10 complement(2308933..2308944) /Source="Nicolas_upshift_promotors" /id="U1833" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=924 /SigmaFactorBS="tgtgcaaaagcgtggtaatttatggtcttttcgagcggaTGA ATGAgaacaaaatcgaaCCACATACTACAtatataaccaccgaaagatggtgatcaat g" /listShort="spoVAA, spoVAB, spoVAC, spoVAD, spoVAEB, spoVAEA, spoVAF, S888, lysA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2308943) /Source="Nicolas_upshifts" /id="U1833" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=924 /SigmaFactorBS="tgtgcaaaagcgtggtaatttatggtcttttcgagcggaTGA ATGAgaacaaaatcgaaCCACATACTACAtatataaccaccgaaagatggtgatcaat g" /listShort="spoVAA, spoVAB, spoVAC, spoVAD, spoVAEB, spoVAEA, spoVAF, S888, lysA" /GFF_Attribute="listLong" promotor_-35 complement(2308958..2308964) /Source="Nicolas_upshift_promotors" /id="U1833" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=924 /SigmaFactorBS="tgtgcaaaagcgtggtaatttatggtcttttcgagcggaTGA ATGAgaacaaaatcgaaCCACATACTACAtatataaccaccgaaagatggtgatcaat g" /listShort="spoVAA, spoVAB, spoVAC, spoVAD, spoVAEB, spoVAEA, spoVAF, S888, lysA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2309027..2309794) /gene="sigF" /locus_tag="BSU_23450" /old_locus_tag="BSU23450" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9891799, 15187183, 15205417, 15819616, 16045607, 22115775, 23169620, 24067622, 26506528" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9891799, 15187183, 15205417, 15819616, 16045607, 22115775, 23169620, 24067622, 26506528; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma factor(sigma-F)" /protein_id="NP_390226.1" /db_xref="EnsemblGenomes-Gn:BSU23450" /db_xref="EnsemblGenomes-Tr:CAB14277" /db_xref="GOA:P07860" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014236" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014322" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10298" /db_xref="UniProtKB/Swiss-Prot:P07860" /translation="MDVEVKKNGKNAQLKDHEVKELIKQSQNGDQQARDLLIEKNMRL VWSVVQRFLNRGYEPDDLFQIGCIGLLKSVDKFDLTYDVRFSTYAVPMIIGEIQRFIR DDGTVKVSRSLKELGNKIRRAKDELSKTLGRVPTVQEIADHLEIEAEDVVLAQEAVRA PSSIHETVYENDGDPITLLDQIADNSEEKWFDKIALKEAISDLEEREKLIVYLRYYKD QTQSEVAERLGISQVQVSRLEKKILKQIKVQMDHTDG*" gene complement(2309027..2309794) /gene="sigF" /locus_tag="BSU_23450" /old_locus_tag="BSU23450" downshifts complement(2309057) /Source="Nicolas_upshifts" /id="D1225" /incds=0 /nref=89 /ntot=197 /MaxReadThrough="1.81932" /MaxDrop="7.16571" /score="21.6169221" /energy="-13.5" /TU="NA" /idTUdmin="U1834" /TUdmin=1 /isTUend="TRUE" CDS complement(2309806..2310246) /gene="spoIIAB" /locus_tag="BSU_23460" /old_locus_tag="BSU23460" /EC_number="2.7.11.-" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15023063, 15187183, 15819616, 16166546, 16824103, 22115775" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15023063, 15187183, 15819616, 16166546, 16824103, 22115775; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="anti-sigma factor (antagonist of sigma(F)) and serine kinase" /protein_id="NP_390227.1" /db_xref="EnsemblGenomes-Gn:BSU23460" /db_xref="EnsemblGenomes-Tr:CAB14278" /db_xref="GOA:P10728" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010194" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10297" /db_xref="UniProtKB/Swiss-Prot:P10728" /translation="MKNEMHLEFSALSQNESFARVTVASFIAQLDPTMDELTEIKTVV SEAVTNAIIHGYEENCEGKVYISVTLEDHVVYMTIRDEGLGITDLEEARQPLFTTKPE LERSGMGFTIMENFMDDVSIDSSPEMGTTIRLTKHLSKSKALCN*" gene complement(2309806..2310246) /gene="spoIIAB" /locus_tag="BSU_23460" /old_locus_tag="BSU23460" CDS complement(2310243..2310596) /gene="spoIIAA" /locus_tag="BSU_23470" /old_locus_tag="BSU23470" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11173484, 15819616, 16824103, 22115775" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11173484, 15819616, 16824103, 22115775; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="anti-anti-sigma factor (antagonist of SpoIIAB)" /protein_id="NP_390228.1" /db_xref="EnsemblGenomes-Gn:BSU23470" /db_xref="EnsemblGenomes-Tr:CAB14279" /db_xref="GOA:P10727" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR003658" /db_xref="InterPro:IPR014237" /db_xref="InterPro:IPR036513" /db_xref="PDB:1AUZ" /db_xref="PDB:1BUZ" /db_xref="SubtiList:BG10296" /db_xref="UniProtKB/Swiss-Prot:P10727" /translation="MSLGIDMNVKESVLCIRLTGELDHHTAETLKQKVTQSLEKDDIR HIVLNLEDLSFMDSSGLGVILGRYKQIKQIGGEMVVCAISPAVKRLFDMSGLFKIIRF EQSEQQALLTLGVAS*" gene complement(2310243..2310596) /gene="spoIIAA" /locus_tag="BSU_23470" /old_locus_tag="BSU23470" promotor_-10 complement(2310621..2310639) /Source="Nicolas_upshift_promotors" /id="U1834" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=445 /SigmaFactorBS="attatgccgaatgaccactagttttgtcacggtGAAGGAATT cattccgtcgaAATCGAAACACTCATTATCcgatcatatcaaggaggaatgagcatga g" /listShort="spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2310632) /Source="Nicolas_upshifts" /id="U1834" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=445 /SigmaFactorBS="attatgccgaatgaccactagttttgtcacggtGAAGGAATT cattccgtcgaAATCGAAACACTCATTATCcgatcatatcaaggaggaatgagcatga g" /listShort="spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" S_feature complement(2310634..2310691) /Source="Nicolas_S_feature" /locus_tag="new_2445036_2445093_c" /HighExp="S4, S3, S7, S5, S8, S6, T5.0H, BT, LoTm, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.859" /TUlongSig="NA" /TUlongPSig="NA" /label="S889" promotor_-35 complement(2310651..2310659) /Source="Nicolas_upshift_promotors" /id="U1834" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=445 /SigmaFactorBS="attatgccgaatgaccactagttttgtcacggtGAAGGAATT cattccgtcgaAATCGAAACACTCATTATCcgatcatatcaaggaggaatgagcatga g" /listShort="spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2310692..2311861) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" /EC_number="3.4.16.4" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8021191, 8936302, 9864321, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021191, 8936302, 9864321, 19189487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicilin binding protein)" /protein_id="NP_390229.1" /db_xref="EnsemblGenomes-Gn:BSU23480" /db_xref="EnsemblGenomes-Tr:CAB14280" /db_xref="GOA:P38422" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10295" /db_xref="UniProtKB/Swiss-Prot:P38422" /translation="MKRLLSTLLIGIMLLTFAPSAFAKQDGKRTSELAHEAKSAVLIE RDTGKVLYNKNSNERLAPASMTKIMTMLLIMEALDKGKIKMSDKVRTSEHAASMGGSQ IFLEPGEEMTVKEMLKGIAIASGNDASVAMAEFISGSEEEFVKKMNKKAKELGLKNTS FKNPTGLTEEGHYSSAYDMAIMAKELLKYESITKFTGTYEDYLRENTDKKFWLVNTNR LIKFYPGVDGVKTGYTGEAKYCLTASAKKGNMRAIAVVFGASTPKERNAQVTKMLDFA FSQYETHPLYKRNQTVAKVKVKKGKQKFIELTTSEPISILTKKGEDMNDVKKEIKMKD NISAPIQKGQELGTLVLKKDGEVLAESPVAAKEDMKKAGFITFLKRTMGDWTKFK*" gene complement(2310692..2311861) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" promotor_-10 complement(2311890..2311901) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2311905) /Source="Nicolas_upshifts" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" promotor_-35 complement(2311915..2311921) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2312007) /Source="Nicolas_upshifts" /id="D1226" /incds=0 /nref=243 /ntot=267 /MaxReadThrough="0.87114" /MaxDrop="7.5376" /score="26.8559416" /energy="-16.7" /TU="NA" /idTUdmin="U1836" /TUdmin="-1" /isTUend="TRUE" CDS complement(2312016..2312831) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 15530033, 21279421, 21543875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 15530033, 21279421, 21543875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_390230.1" /db_xref="EnsemblGenomes-Gn:BSU23490" /db_xref="EnsemblGenomes-Tr:CAB14281" /db_xref="GOA:P46354" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR011268" /db_xref="InterPro:IPR011270" /db_xref="InterPro:IPR018099" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG11330" /db_xref="UniProtKB/Swiss-Prot:P46354" /translation="MKDRIERAAAFIKQNLPESPKIGLILGSGLGILADEIENPVKLK YEDIPEFPVSTVEGHAGQLVLGTLEGVSVIAMQGRFHFYEGYSMEKVTFPVRVMKALG VEALIVTNAAGGVNTEFRAGDLMIITDHINFMGTNPLIGPNEADFGARFPDMSSAYDK DLSSLAEKIAKDLNIPIQKGVYTAVTGPSYETPAEVRFLRTMGSDAVGMSTVPEVIVA NHAGMRVLGISCISNAAAGILDQPLSHDEVMEVTEKVKAGFLKLVKAIVAQYE*" gene complement(2312016..2312831) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" CDS complement(2312844..2314028) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" /EC_number="5.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,5-phosphopentomutase" /protein_id="NP_390231.2" /db_xref="EnsemblGenomes-Gn:BSU23500" /db_xref="EnsemblGenomes-Tr:CAB14282" /db_xref="GOA:P46353" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR010045" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR024052" /db_xref="SubtiList:BG11331" /db_xref="UniProtKB/Swiss-Prot:P46353" /translation="MPAYKYNRVFLIVMDSVGIGEAPDAADFNDEGAHTLGHIAEHMN GLHMPNMAKLGLGLIEDIKGVEKTEHPLAYYGKMQEASNGKDTMTGHWEIMGLYIDKP FKVFPEGFPDELLQELEKRSGRKIIGNKPASGTAILDELGQEHMETGALIVYTSADSV LQIAAHEEVVPLEELYRICETARELTLDPKYMVGRIIARPFVGEPGQFKRTPNRHDYA LKPFDRTVMNELKDCGLDVISIGKISDIYDGEGITSSRRTVSNMDGMDKVIDTLGEDF TGLSFANLVDFDALFGHRRDPEGYGRALEEFDARLPEVFEKMREDDLLIITADHGNDP IHHGTDHTREYVPILAYSKKHKKAQMLPLADTFADIGATIADNFQTNKPKYGKSFLSL LQ*" gene complement(2312844..2314028) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" promotor_-10 complement(2314077..2314096) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2314095) /Source="Nicolas_upshifts" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" S_feature complement(2314097..2314188) /Source="Nicolas_S_feature" /locus_tag="new_2448499_2448590_c" /HighExp="S3, S4, M0t90, G180, S7, S8, Glucon, G135, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigEF, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S890" promotor_-35 complement(2314112..2314119) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2314189..2315079) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_390232.2" /db_xref="EnsemblGenomes-Gn:BSU23510" /db_xref="EnsemblGenomes-Tr:CAB14283" /db_xref="GOA:P46352" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011932" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG11332" /db_xref="UniProtKB/Swiss-Prot:P46352" /translation="MKDQIKDFIHYVMVERGLSQNTIVSYERDLKSYSLYLTETLHVT DWNHVTRIHIIQYLKHLKDSGKSGKTSARHLASIRSFHQFLLREKVTDKDPSVHIETQ KTERALPKVLALNEVERLLDTPKLTSPFGYRDKAMLELLYATGIRVSEMIELKTADVH LSMGFIRCFGKGRKERIVPIGEAAASAIEEYMTKARGKLLKNNVSDALFLNHHGKQIS RQGFWKNLKKIALEAGIKKELTPHTLRHSFATHLLENGADLRAVQEMLGHADISTTQI YTHVTKTRLKDVYKQFHPRA*" gene complement(2314189..2315079) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" CDS complement(2315087..2315314) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097760.1" /db_xref="EnsemblGenomes-Gn:BSU23519" /db_xref="EnsemblGenomes-Tr:CAX52660" /db_xref="GOA:C0H451" /db_xref="InterPro:IPR025321" /db_xref="UniProtKB/Swiss-Prot:C0H451" /translation="MGRFLKTAVDALKVFILFTGFTALFYYAMIWVNQEYENYHRYDK PEGSAVKVVEMDQDEKGGWFDRLIFFYQNGE*" gene complement(2315087..2315314) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" promotor_-10 complement(2315217..2315236) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2315228) /Source="Nicolas_upshifts" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" promotor_-35 complement(2315250..2315257) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2315307) /Source="Nicolas_upshifts" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" promotor_-10 complement(2315316..2315334) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2315344..2315362) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2315350..2315356) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2315357) /Source="Nicolas_upshifts" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" promotor_-35 complement(2315379..2315384) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2315439) /Source="Nicolas_upshifts" /id="D1227" /incds=0 /nref=159 /ntot=251 /MaxReadThrough="4.06128" /MaxDrop="5.73495" /score="5.40881961" /energy="-8.1" /TU="U1840" /idTUdmin="U1841" /TUdmin=506 /isTUend="FALSE" CDS complement(2315439..2315888) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for iron transport andmetabolism" /protein_id="NP_390233.2" /db_xref="EnsemblGenomes-Gn:BSU23520" /db_xref="EnsemblGenomes-Tr:CAB14284" /db_xref="GOA:P54574" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11766" /db_xref="UniProtKB/Swiss-Prot:P54574" /translation="MENRIDRIKKQLHSSSYKLTPQREATVRVLLENEEDHLSAEDVY LLVKEKSPEIGLATVYRTLELLTELKVVDKINFGDGVSRYDLRKEGAAHFHHHLVCME CGAVDEIEEDLLEDVEEIIERDWKFKIKDHRLTFHGICHRCNGKETE*" gene complement(2315439..2315888) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" promotor_-10 complement(2315912..2315931) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-10" upshifts complement(2315922) /Source="Nicolas_upshifts" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" S_feature complement(2315924..2316000) /Source="Nicolas_S_feature" /locus_tag="new_2450326_2450402_c" /HighExp="S3, S4, S5, BT, LoTm, M9-stat, T5.0H, T3.30H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S891" promotor_-35 complement(2315947..2315951) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-35" CDS complement(2316001..2316645) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17376078, 17824930, 20382772, 23859254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17376078, 17824930, 20382772, 23859254; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="autolysin component for dissolution of the septal cell wall (stage II sporulation)" /protein_id="NP_390234.1" /db_xref="EnsemblGenomes-Gn:BSU23530" /db_xref="EnsemblGenomes-Tr:CAB14285" /db_xref="GOA:P37873" /db_xref="InterPro:IPR002798" /db_xref="InterPro:IPR014196" /db_xref="SubtiList:BG10768" /db_xref="UniProtKB/Swiss-Prot:P37873" /translation="MRKISYKDMFLRHVKDHLSLYIFVSVLFFMGVIFGAIIVNSMTI SQKEDLYYYLSQFFGQLSDGKQASSADMFGQSIFHNAKYLGLMWILGISVIGMPIIFI MIFLKGIVVGFTVGFLVNQMGVSGFFLSFVSVLPQNVLLIPAYLIMGTCAIAFSLKLI RQLFVKRSLHDAPIQWFGRYAFVLLVILFLALISSLFEAYLSPVLMEKLTSRLF*" gene complement(2316001..2316645) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" promotor_-10 complement(2316676..2316694) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-10" upshifts complement(2316693) /Source="Nicolas_upshifts" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" promotor_-35 complement(2316709..2316714) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-35" CDS complement(2316746..2316961) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390235.1" /db_xref="EnsemblGenomes-Gn:BSU23540" /db_xref="EnsemblGenomes-Tr:CAB14286" /db_xref="SubtiList:BG11765" /db_xref="UniProtKB/Swiss-Prot:P54573" /translation="MAKSQAKKKRGHRLRNGGRDVLLSRGSTPSFSTHGRMTKSKKEI LNKRKHKNPYDHTAVDDKDFFVPQKAA*" gene complement(2316746..2316961) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" downshifts complement(2316826) /Source="Nicolas_upshifts" /id="D1228" /incds=1 /nref=17 /ntot=130 /MaxReadThrough="0.857610000000001" /MaxDrop="3.7055" /score="1.77181315" /energy="-9.8" /TU="NA" /idTUdmin="U1842" /TUdmin="-1" /isTUend="TRUE" CDS complement(2317061..2318380) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 23136871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catabolic NAD-dependent malic enzyme (conversionof malate into pyruvate)" /protein_id="NP_390236.1" /db_xref="EnsemblGenomes-Gn:BSU23550" /db_xref="EnsemblGenomes-Tr:CAB14287" /db_xref="GOA:P54572" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11764" /db_xref="UniProtKB/Swiss-Prot:P54572" /translation="MIAKHMIRTLMIETPSVPGNLGRVATAIGLLGGDIGEVETVKVG PNYTMRNITVQVENEEQLQEVIAAVQALGEGIRLHTVSDEVLSAHEGGKIQMKSKMPI RSLAELGRVYTPGVADVCRLIEKEPEKASIYTTISNSVAIVTDGTAILGLGNIGSVAG MPVMEGKAALFDQLAGISGIPILLDTSDPEEIIKTVKHISPGFSGILLEDIGSPHCFE IEDRLKEELNIPVMHDDQHGTAVVTLAAAISACRSAGVDLKEAKVGQIGLGAAGVAIC RMFMAYGVNAVYGTDKSESAMNRLEQYGGQAVSSIEELMETCDIVIATTGVPGLIKPA FVRSGQVILALSNPKPEIEPEAALQAGAAYAADGRSVNNVLGFPGIFRGALNAKSTEI NHDMLVAAAEAIAACTKQGDVVPQPLDSKVHHAVAAAVEHAALTAVK*" gene complement(2317061..2318380) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" downshifts complement(2317068) /Source="Nicolas_upshifts" /id="D1229" /incds=0 /nref=29 /ntot=84 /MaxReadThrough="3.50516" /MaxDrop="5.65279" /score="42.1653011" /energy="-15.2" /TU="U1842,U1843" /idTUdmin="U1842" /TUdmin="-243" /isTUend="FALSE" CDS complement(2318398..2319804) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10903309, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10903309, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="malate-H+/Na+-lactate antiporter" /protein_id="NP_390237.1" /db_xref="EnsemblGenomes-Gn:BSU23560" /db_xref="EnsemblGenomes-Tr:CAB14288" /db_xref="GOA:P54571" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG11763" /db_xref="UniProtKB/Swiss-Prot:P54571" /translation="MKDVRLPTLFEIIIVLGVFLALVLSFTVFLDLPIQLALFVSWFI AMLLGIRLGYSYKDLQNAIVHGISNGLEAVLILVSVGALIGTWIAGGVVPTLIYYGLE FIHPSIFLLATLIICSIMSVATGTSWGTVGTAGIAMIAIGEGLGIPLPLVAGAILSGA YFGDKLSPLSDSTVLASSLSKVDVLAHVRAMLYLSIPAYVITAILFTVVGFMYGGKNI DLDKVEFLKSSLQNTFDIHIWMLIPAVLVIVLLAMKKPSMPVIVIGALLGAIWAVVFQ GMDIAHAIATAYNGFSIKTDVEFLNGLLNRGGIVGMLDSLVVIIFGLGFGGLLEKLGV LKVIVSTFEKKLTSAGNVTLSTLIVAFLANIFGCAMYVSLILTPKIMEDSYDRLHLDR RVLSRNSEVGGTLTSGMVPWSDNGIYMAGILGVSTFSYLPFMWLSFVAIGLAIIYGYT GKFIWYTKNNTVKAEKLG*" gene complement(2318398..2319804) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" promotor_-10 complement(2319852..2319871) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2319861) /Source="Nicolas_upshifts" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" S_feature complement(2319863..2319944) /Source="Nicolas_S_feature" /locus_tag="new_2454265_2454346_c" /HighExp="S0, dia0, dia5, Lbexp, G150, Oxctl, G135, Mt0, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S892" promotor_-35 complement(2319886..2319893) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2319945..2321372) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" /EC_number="4.3.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-aspartase (aspartate ammonia lyase)" /protein_id="NP_390238.2" /db_xref="EnsemblGenomes-Gn:BSU23570" /db_xref="EnsemblGenomes-Tr:CAB14289" /db_xref="GOA:P26899" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004708" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10301" /db_xref="UniProtKB/Swiss-Prot:P26899" /translation="MLNGQKEYRVEKDFLGEKQIEADVYYGIQTLRASENFPITGYKI HEEMINALAIVKKAAALANMDVKRLYEGIGQAIVQAADEILEGKWHDQFIVDPIQGGA GTSMNMNANEVIGNRALEIMGHKKGDYIHLSPNTHVNMSQSTNDVFPTAIHISTLKLL EKLLKTMEDMHSVFKQKAQEFDSVIKMGRTHLQDAVPIRLGQEFEAYSRVLERDIKRI KQSRQHLYEVNMGATAVGTGLNADPEYIKQVVKHLADISGLPLVGADHLVDATQNTDA YTEVSASLKVCMMNMSKIANDLRLMASGPRAGLAEISLPARQPGSSIMPGKVNPVMAE LINQIAFQVIGNDNTICLASEAGQLELNVMEPVLVFNLLQSISIMNNGFRSFTDNCLK GIEANEKRMKQYVEKSAGVITAVNPHLGYEAAARIAREAIMTGQSVRDLCLQHDVLTE EELDIILNPYEMTKPGIAGKELLEK*" gene complement(2319945..2321372) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" CDS complement(2321417..2322406) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" /EC_number="3.5.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029, 11914346, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029, 11914346, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported L-asparaginase" /protein_id="NP_390239.1" /db_xref="EnsemblGenomes-Gn:BSU23580" /db_xref="EnsemblGenomes-Tr:CAB14290" /db_xref="GOA:P26900" /db_xref="InterPro:IPR006033" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG10300" /db_xref="UniProtKB/Swiss-Prot:P26900" /translation="MKKLLMLTTGGTIASVEGENGLAPGVKADELLSYVSKLDNDYTM ETQSLMNIDSTNMQPEYWVEIAEAVKENYDAYDGFVITHGTDTMAYTSAALSYMLQHA KKPIVITGSQIPITFQKTDAKKNITDAIRFACEGVGGVYVVFDGRVIQGTRAIKLRTK SYDAFESINYPYIAFINEDGIEYNKQVTEPENDTFTVDTSLCTDVCLLKLHPGLKPEM FDALKSMYKGIVIESYGSGGVPFEGRDILSKVNELIESGIVVVITTQCLEEGEDMSIY EVGRRVNQDLIIRSRNMNTEAIVPKLMWALGQSSDLPVVKRIMETPIADDVVL*" gene complement(2321417..2322406) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" S_feature complement(2322407..2322486) /Source="Nicolas_S_feature" /locus_tag="new_2456809_2456888_c" /HighExp="dia0, Lbexp, G150, Oxctl, dia5, LBGexp, Paraq, C30, G180, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S893" promotor_-10 complement(2322468..2322487) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2322486) /Source="Nicolas_upshifts" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" S_feature complement(2322488..2322808) /Source="Nicolas_S_feature" /locus_tag="new_2456890_2457210_c" /HighExp="LBGstat, S5, G135, S8, S6, LBGtran, G180, G150, LoTm, LBGexp" /AntisenseName="ansR" /AntisenseCor="0.23077291929287899" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S894" promotor_-35 complement(2322502..2322509) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2322527..2322534 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2322547..2322566 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2322549 /Source="Nicolas_upshifts" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" CDS 2322588..2322938 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of ansAB (Xre family)" /protein_id="NP_390240.1" /db_xref="EnsemblGenomes-Gn:BSU23590" /db_xref="EnsemblGenomes-Tr:CAB14291" /db_xref="GOA:Q07683" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR027910" /db_xref="SubtiList:BG10299" /db_xref="UniProtKB/Swiss-Prot:Q07683" /translation="MNLDRLTELRKKKNWSLQYTADLLGIAKSTYAGYESGYRRPSLE ALAMLADLFDTTCDELLGREKQKQTAPQAIELATWSSLDFTISVDGQPLSEDEIIQLI TFIRTKRKVQEELS*" gene 2322588..2322938 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" S_feature complement(2322810..2322946) /Source="Nicolas_S_feature" /locus_tag="new_2457212_2457348_c" /HighExp="LBGstat, S8, S6, S7, S5, ferm, nit, LBGtran, BT, LPhT" /AntisenseName="ansR" /AntisenseCor="-0.22421651781702501" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S895" downshifts complement(2322853) /Source="Nicolas_upshifts" /id="D1230" /incds=1 /nref=4 /ntot=116 /MaxReadThrough="3.90926" /MaxDrop="4.76642" /score="10.2434094" /energy="-23.6" /TU="U1847" /idTUdmin="U1845" /TUdmin=1451 /isTUend="FALSE" CDS complement(2322947..2324110) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleotide binding protein" /protein_id="NP_390241.2" /db_xref="EnsemblGenomes-Gn:BSU23600" /db_xref="EnsemblGenomes-Tr:CAB14292" /db_xref="GOA:P38423" /db_xref="InterPro:IPR005287" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG11073" /db_xref="UniProtKB/Swiss-Prot:P38423" /translation="MKKIYADLHIHIGRTFTGRAVKITGAKTLTLDRILVEASEHKGI ELLGIIDCHSPEVILELEEGISSGKYRELDGGGIRYRSTTLLLGSELEIYDEACSGPI HVLVFMPTLADMKQFSNWLSARLKNIHLSSQRIYETGLNLQKKVQDMGGLFIPAHIFT PHKSLYGKGVKSSLTEVFDPSMIDAVELGLSCDTDMASHVSQLNPYPFLTNSDAHSLG KIGREYNELYVQSADFTEFALALKGQDDRKIIANYGLDPLLGKYYQTACEACGEPAVS GETACANCGKARFTKGVSDRLRELSDQLEVRVPRPRYVHQIPLQFVPGVGPKTLDKLK KAFGTEMAVLHEAAEEDLARVVPPKTAALIVKARSGKLELKAGGGGTYGKIKP*" gene complement(2322947..2324110) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" CDS complement(2324107..2324664) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" /EC_number="3.1.7.1" /EC_number="3.6.1.13" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10542272, 17693564, 21638333, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl pyrophosphate and dimethylallyl pyrophosphate diphosphatase (moonlighting ADP-ribose pyrophosphatase)" /protein_id="NP_390242.1" /db_xref="EnsemblGenomes-Gn:BSU23610" /db_xref="EnsemblGenomes-Tr:CAB14293" /db_xref="GOA:P54570" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11762" /db_xref="UniProtKB/Swiss-Prot:P54570" /translation="MKSLEEKTIAKEQIFSGKVIDLYVEDVELPNGKASKREIVKHPG AVAVLAVTDEGKIIMVKQFRKPLERTIVEIPAGKLEKGEEPEYTALRELEEETGYTAK KLTKITAFYTSPGFADEIVHVFLAEELSVLEEKRELDEDEFVEVMEVTLEDALKLVES REVYDAKTAYAIQYLQLKEALQAQK*" gene complement(2324107..2324664) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" promotor_no_box complement(2324594..2324694) /Source="Nicolas_upshift_promotors" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2324634) /Source="Nicolas_upshifts" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" promotor_-35 2324678..2324683 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2324699..2324717 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2324701..2324715) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-10" upshifts 2324705 /Source="Nicolas_upshifts" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" S_feature 2324712..2324886 /Source="Nicolas_S_feature" /locus_tag="new_2459114_2459288" /HighExp="S4, S5, S3, S7, S6, LoTm, BT, T5.0H, G/S, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99962399999999996" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S896" promotor_-35 complement(2324717..2324720) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-35" upshifts complement(2324720) /Source="Nicolas_upshifts" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" CDS 2324739..2324861 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" /function="15.1: Cell division" /experiment="publication(s) with functional evidences, PMID:18284588, 23237472, 25848052, 27752253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18284588, 23237472, 25848052, 27752253; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="YP_009513976.1" /db_xref="EnsemblGenomes-Gn:BSU23616" /db_xref="EnsemblGenomes-Tr:CCQ48600" /db_xref="GOA:L8EBJ9" /db_xref="InterPro:IPR025177" /db_xref="PDB:2MRW" /db_xref="PDB:4U39" /db_xref="UniProtKB/TrEMBL:L8EBJ9" /translation="MKVHRMPKGVVLVGKAWEIRAKLKEYGRTFQYVKDWISKP*" gene 2324739..2324861 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" promotor_-35 2324862..2324869 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2324883..2324902 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2324888 /Source="Nicolas_upshifts" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" CDS 2324924..2325844 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" /EC_number="1.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9643546, 15317791, 16242712, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent aldo-keto reductase (acts on 4-hydroxy-2,3-trans-nonenal)" /protein_id="NP_390243.1" /db_xref="EnsemblGenomes-Gn:BSU23620" /db_xref="EnsemblGenomes-Tr:CAB14294" /db_xref="GOA:P54569" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11761" /db_xref="UniProtKB/Swiss-Prot:P54569" /translation="MRKRKLGTSDLDISEVGLGCMSLGTEKNKALSILDEAIELGINY LDTADLYDRGRNEEIVGDAIQNRRHDIILATKAGNRWDDGSEGWYWDPSKAYIKEAVK KSLTRLKTDYIDLYQLHGGTIEDNIDETIEAFEELKQEGVIRYYGISSIRPNVIKEYV KKSNIVSIMMQFSLFDRRPEEWLPLLEEHQISVVARGPVAKGLLTEKPLDQASESMKQ NGYLSYSFEELTNARKAMEEVAPDLSMTEKSLQYLLAQPAVASVITGASKIEQLRENI QAANARRLTEEEIKALQSHTKQDIYKAHRS*" gene 2324924..2325844 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" downshifts 2325833 /Source="Nicolas_upshifts" /id="D1231" /incds=0 /nref=186 /ntot=248 /MaxReadThrough="1.49159" /MaxDrop="5.81013" /score="18.6018806" /energy="-14.8" /TU="NA" /idTUdmin="U1846" /TUdmin="-1" /isTUend="TRUE" CDS complement(2325876..2326100) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390244.1" /db_xref="EnsemblGenomes-Gn:BSU23630" /db_xref="EnsemblGenomes-Tr:CAB14295" /db_xref="InterPro:IPR024980" /db_xref="SubtiList:BG11760" /db_xref="UniProtKB/Swiss-Prot:P54568" /translation="MKKQKSIDKHQLKDGLQSDIKAKLMEMKSQLKEEDEKRQKREKA EQIRKKKEIEKNKSFEELLNESQMDWHQYK*" gene complement(2325876..2326100) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" downshifts complement(2325933) /Source="Nicolas_upshifts" /id="D1232" /incds=0 /nref=19 /ntot=195 /MaxReadThrough="0.59953" /MaxDrop="5.9087" /score="15.8160537" /energy="-13" /TU="NA" /idTUdmin="U1849" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(2326123..2326142) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2326130) /Source="Nicolas_upshifts" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" promotor_-35 complement(2326157..2326164) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2326179..2326186 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2326201..2326220 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2326208 /Source="Nicolas_upshifts" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" CDS 2326262..2327179 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390245.1" /db_xref="EnsemblGenomes-Gn:BSU23640" /db_xref="EnsemblGenomes-Tr:CAB14296" /db_xref="GOA:P54567" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11759" /db_xref="UniProtKB/Swiss-Prot:P54567" /translation="MKKILLAIGALVTAVIAIGIVFSHMILFIKKKTDEDIIKRETDN GHDVFESFEQMEKTAFVIPSAYGYDIKGYHVAPHDTPNTIIICHGVTMNVLNSLKYMH LFLDLGWNVLIYDHRRHGQSGGKTTSYGFYEKDDLNKVVSLLKNKTNHRGLIGIHGES MGAVTALLYAGAHCSDGADFYIADCPFACFDEQLAYRLRAEYRLPSWPLLPIADFFLK LRGGYRAREVSPLAVIDKIEKPVLFIHSKDDDYIPVSSTERLYEKKRGPKALYIAENG EHAMSYTKNRHTYRKTVQEFLDNMNDSTE*" gene 2326262..2327179 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" downshifts 2327154 /Source="Nicolas_upshifts" /id="D1233" /incds=0 /nref=27 /ntot=171 /MaxReadThrough="2.02201" /MaxDrop="3.99393" /score="14.106821" /energy="-11.8" /TU="NA" /idTUdmin="U1850" /TUdmin=594 /isTUend="FALSE" CDS complement(2327219..2327458) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390246.1" /db_xref="EnsemblGenomes-Gn:BSU23650" /db_xref="EnsemblGenomes-Tr:CAB14297" /db_xref="InterPro:IPR020157" /db_xref="SubtiList:BG11758" /db_xref="UniProtKB/Swiss-Prot:P54566" /translation="MEQKLKAMKNTAQNKTWVSFLNQNHPYTLLHWSIGGAESIKKDV WLLQDEMTFETQEFTTIDLAIEWIRENMDGITDVL*" gene complement(2327219..2327458) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" downshifts complement(2327230) /Source="Nicolas_upshifts" /id="D1234" /incds=0 /nref=215 /ntot=269 /MaxReadThrough="3.31829" /MaxDrop="6.35785" /score="16.3526162" /energy="-11.2" /TU="NA" /idTUdmin="U1851" /TUdmin=0 /isTUend="TRUE" CDS complement(2327471..2327794) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390247.1" /db_xref="EnsemblGenomes-Gn:BSU23660" /db_xref="EnsemblGenomes-Tr:CAB14298" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11757" /db_xref="UniProtKB/Swiss-Prot:P54565" /translation="MNIHVTDAAKQALQQAFDANPGKKAQLRYDAEGCGCAVSGVPTI WLAEELTGQCEQLETNGIPLYIQSSQKVFFDDQMTIDYNEKAKTLALKSPAEMLSPRM SILVK*" gene complement(2327471..2327794) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" promotor_-10 complement(2327537..2327556) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2327538) /Source="Nicolas_upshifts" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" promotor_-35 complement(2327570..2327577) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2327791..2328822) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390248.1" /db_xref="EnsemblGenomes-Gn:BSU23670" /db_xref="EnsemblGenomes-Tr:CAB14299" /db_xref="GOA:P54564" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR007344" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11756" /db_xref="UniProtKB/Swiss-Prot:P54564" /translation="MIEFLQHKEATIAREILAVQIPAYIKETEIIGFDGIPALQEKVK DIQASHERFAGYRKNGKLIGVISYEKNMHYLTICRLVVHPDGFRKGIGRALLQFVIDH NEDAEKIEVVTAENNTPAVSLYTQAGFQKAETVKAAQGLLLSVFHLYPKRKVEIILYN EKWAECFDEEKERLKLVFGPEIIAIHHIGSTSIPNMAAKPIIDMLIEVRSIEAVSQFD EQMKANGYTPKGENGIAGRRYFQKGGNKRTHHVHMYEQGNPAIERHLLFRDYLRAHPN IAKEYAVLKKQLAAQHPDSINQYIQGKDEWIKTAEENAKRWKKGRNNANGSIVCYNSE NDENGGFTL*" gene complement(2327791..2328822) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" promotor_-10 complement(2327818..2327837) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2327825) /Source="Nicolas_upshifts" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" promotor_-35 complement(2327848..2327855) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2328815..2329159) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradation enzyme (oxygenase)" /protein_id="NP_390249.1" /db_xref="EnsemblGenomes-Gn:BSU23680" /db_xref="EnsemblGenomes-Tr:CAB14300" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:2GO8" /db_xref="SubtiList:BG11755" /db_xref="UniProtKB/Swiss-Prot:P54563" /translation="MMDFLSKTPEPPYYAVIFSSVKSENDTGYGETAERMVSLAADQP GFLGVESVREADGRGITVSYWDSMDAINHWRHHTEHQAAKEKGRSVWYESYAVRVAKV DRQRLFQENTND*" gene complement(2328815..2329159) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" CDS complement(2329169..2329639) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390250.1" /db_xref="EnsemblGenomes-Gn:BSU23690" /db_xref="EnsemblGenomes-Tr:CAB14301" /db_xref="GOA:P54562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017255" /db_xref="PDB:1MK4" /db_xref="SubtiList:BG11754" /db_xref="UniProtKB/Swiss-Prot:P54562" /translation="MDIRTITSSDYEMVTSVLNEWWGGRQLKEKLPRLFFEHFQDTSF ITSEHNSMTGFLIGFQSQSDPETAYIHFSGVHPDFRKMQIGKQLYDVFIETVKQRGCT RVKCVTSPVNKVSIAYHTKLGFDIEKGTKTVNGISVFANYDGPGQDRVLFVKNI*" gene complement(2329169..2329639) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" S_feature complement(2329640..2329716) /Source="Nicolas_S_feature" /locus_tag="new_2464042_2464118_c" /HighExp="SMM, T-4.40H, MG 150, M9-tran, GM 90, T-3.40H, GM-0.2, M9-exp, GM 120, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigEF" /TUlongPSig="0.776" /label="S897" downshifts 2329640 /Source="Nicolas_upshifts" /id="D1235" /incds=0 /nref=8 /ntot=121 /MaxReadThrough="0.87367" /MaxDrop="3.61005" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin="-748" /isTUend="FALSE" promotor_-10 complement(2329691..2329710) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2329716) /Source="Nicolas_upshifts" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" S_feature complement(2329718..2329824) /Source="Nicolas_S_feature" /locus_tag="new_2464120_2464226_c" /HighExp="M40t90, S4, M40t45, S6, H2O2, S5, S3, S8, S7, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.776" /TUlongSig="NA" /TUlongPSig="NA" /label="S898" promotor_-35 complement(2329725..2329732) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2329825..2330163) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12137951, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390251.1" /db_xref="EnsemblGenomes-Gn:BSU23700" /db_xref="EnsemblGenomes-Tr:CAB14302" /db_xref="GOA:P54561" /db_xref="InterPro:IPR014962" /db_xref="SubtiList:BG11753" /db_xref="UniProtKB/Swiss-Prot:P54561" /translation="MNDHLKRGNLLWEGSRMFLPEHKQSLLERKRLKQKLQKPILDPD KLEEMNQTLCAAMEFAQDITVSCFQDGEIVCCTGKICRYEEFEKAVWIKGDEDQLYKL KLDQVLDIVL*" gene complement(2329825..2330163) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" CDS complement(2330160..2331398) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" /EC_number="2.7.7.7" /function="16.5: Explore" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Y family DNA polymerase V bypassing lesions during replication" /protein_id="NP_390252.1" /db_xref="EnsemblGenomes-Gn:BSU23710" /db_xref="EnsemblGenomes-Tr:CAB14303" /db_xref="GOA:P54560" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11752" /db_xref="UniProtKB/Swiss-Prot:P54560" /translation="MMKEKVIFLVDMQSFYASVEKAENPHLKNRPVIVSGDPEKRGGV VLAACPLAKQKGVVNASRLWEAQEKCPEAVVLRPRMQRYIDVSLQITAILEEYTDLVE PYSIDEQFMDITGSQKLFGTPMEIAKSIQGRIMREIGVYARVGIGPNKALAKIACDNF AKKNKNGIFTLTKENMKTEMWPLPVGSMFGVGSRMKHHLNRMGISTIGGLAAFPLDLL KKKWGINGHVLWMTANGIDYSPVSTSSLDGQKAIGHGMTLPRDYEHFDKEIKVVLLEL SEEVCRRSRNAGVMGQTVSVSCRGADFDWPTGFNRQVKLAEPTNSTQDVYEAVRRLFL TFWDGKPVRRLGVNLSQLSSDDIWQLNLFQDYAKKMSLGYVMDGIKNRFGDTAIIRAA SLTAAGQAFERAAKIGGHYK*" gene complement(2330160..2331398) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" misc_feature 2330322..2330323 /Source="Nicolas_upshift_promotors" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2330333 /Source="Nicolas_upshifts" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2330388 /Source="Nicolas_upshifts" /id="D1236" /incds=1 /nref=2 /ntot=2 /MaxReadThrough="-0.14995" /MaxDrop="4.86715" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2331423..2331441) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-10" upshifts complement(2331432) /Source="Nicolas_upshifts" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" promotor_-35 complement(2331458..2331463) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-35" promotor_-35 2331503..2331506 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2331521..2331540 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2331530 /Source="Nicolas_upshifts" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" CDS 2331564..2331770 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390253.1" /db_xref="EnsemblGenomes-Gn:BSU23720" /db_xref="EnsemblGenomes-Tr:CAB14304" /db_xref="InterPro:IPR025546" /db_xref="SubtiList:BG13774" /db_xref="UniProtKB/Swiss-Prot:O32014" /translation="MEKFVEKMLGQALRQYGRNVAIDPLSPYEKQSLKAALQERRNEE PDEDLHAHIEDIIYDYVTNQGLFS*" gene 2331564..2331770 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" promotor_-35 2332253..2332256 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2332271..2332290 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2332287 /Source="Nicolas_upshifts" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" CDS 2332319..2333551 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390254.2" /db_xref="EnsemblGenomes-Gn:BSU23730" /db_xref="EnsemblGenomes-Tr:CAB14305" /db_xref="GOA:P54559" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11751" /db_xref="UniProtKB/Swiss-Prot:P54559" /translation="MKKWKDIHPISWTIIIGTIFGRMATSMSIPFLAIYLTAVQGASA SYAGLVIAASSSVGILASFYGGYISDKFGRKNMMLVSIFGWMLVFAGFAAASNLWVFF VVNALNGLCKSLFEPASKALLSDMTEEKTRLLVFNLRYAAINIGVVFGPVLGLYFGSS QSTTPFLVPAVIYGLYGIVLALQFKKHPSLSAPAQSRNMSVREAFMVTQKDYLFTIAL VGITLCTFGYSQFSSTFPQYMAQNPLIGNGTKLYGLMLTLNAIVVLATQFPIVHFAKR FSPLCSLMLGNVMVSISMAIFTVSHGVPSIVMIVITFTIGEVLLFSMMDLYVDQIAKP GLKGTYFGAIGFSQLGNVIGPWVGGICIDLFGAGRPIYIFSVLSGITLLGLPFLAFAY RQMKMETTKHRSRLEKPL*" gene 2332319..2333551 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" CDS 2333398..2333760 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390255.2" /db_xref="EnsemblGenomes-Gn:BSU23740" /db_xref="EnsemblGenomes-Tr:CAB14306" /db_xref="GOA:P54558" /db_xref="SubtiList:BG11750" /db_xref="UniProtKB/Swiss-Prot:P54558" /translation="MYRPVWRWPADLYFFCPERHYPARPAIFSVRLSANENGDHKTPF PSGKAALNKKRKRMNLSRKHEVKNMNIGDVMFQLFVFIIFAAVVFAAVTGFKYAKNRK AQLDRIEKKLNSLSEDHD*" gene 2333398..2333760 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" S_feature complement(2333577..2333756) /Source="Nicolas_S_feature" /locus_tag="new_2467979_2468158_c" /HighExp="Sw, BC, C90, C30, M0t90, BI, Lbtran, Lbstat, M40t45, G135" /AntisenseName="yqjU" /AntisenseCor="-0.38632421151235602" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S899" downshifts complement(2333610) /Source="Nicolas_upshifts" /id="D1237" /incds=0 /nref=59 /ntot=226 /MaxReadThrough="1.66997" /MaxDrop="4.81479" /score="21.7095422" /energy="-11.4" /TU="NA" /idTUdmin="U1858" /TUdmin=0 /isTUend="TRUE" CDS complement(2333757..2334143) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390256.1" /db_xref="EnsemblGenomes-Gn:BSU23750" /db_xref="EnsemblGenomes-Tr:CAB14307" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11749" /db_xref="UniProtKB/Swiss-Prot:P54557" /translation="MHHIELYVSDLEASRRFWGWFLKELGYKEYQKWSSGISWKKDRF YLVIVQAKEPFLEPEYHRCRVGLNHLAFHAESKLQVDQMTEKLTAKGYRVLYRDRHPF AGGDGHYAVFCEDPDRIKVELVAPSC*" gene complement(2333757..2334143) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" CDS complement(2334147..2335106) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328157, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328157, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase" /protein_id="NP_390257.2" /db_xref="EnsemblGenomes-Gn:BSU23760" /db_xref="EnsemblGenomes-Tr:CAB14308" /db_xref="GOA:P54556" /db_xref="InterPro:IPR004566" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11748" /db_xref="UniProtKB/Swiss-Prot:P54556" /translation="MKNKELNLHTLYTQHNRESWSGFGGHLSIAVSEEEAKAVEGLND YLSVEEVETIYIPLVRLLHLHVKSAAERNKHVNVFLKHPHSAKIPFIIGIAGSVAVGK STTARILQKLLSRLPDRPKVSLITTDGFLFPTAELKKKNMMSRKGFPESYDVKALLEF LNDLKSGKDSVKAPVYSHLTYDREEGVFEVVEQADIVIIEGINVLQSPTLEDDRENPR IFVSDFFDFSIYVDAEESRIFTWYLERFRLLRETAFQNPDSYFHKFKDLSDQEADEMA ASIWESVNRPNLYENILPTKFRSDLILRKGDGHKVEEVLVRRV*" gene complement(2334147..2335106) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" S_feature complement(2335107..2335177) /Source="Nicolas_S_feature" /locus_tag="new_2469509_2469579_c" /HighExp="LBGtran, dia15, Diami, C90, H2O2, M0t45, G135, Lbtran, HiTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S900" CDS complement(2335178..2336524) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" /EC_number="4.3.1.18" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-serine ammonia-lyase" /protein_id="NP_390258.2" /db_xref="EnsemblGenomes-Gn:BSU23770" /db_xref="EnsemblGenomes-Tr:CAB14309" /db_xref="GOA:P54555" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011780" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG11747" /db_xref="UniProtKB/Swiss-Prot:P54555" /translation="MSVHSEVLHALLKDPFIQKLIDAEPVFWANSGKKEGPLPRADEW ATEIAEAEKRMQRFAPYIAEVFPETKGAKGIIESPLFEVQHMKGKLEAAYQQPFPGRW LLKCDHELPISGSIKARGGIYEVLKYAENLALQEGMLQETDDYRILQEERFTGFFSRY SIAVGSTGNLGLSIGIIGAALGFRVTVHMSADAKQWKKDLLRQKGVTVMEYETDYSEA VNEGRRQAEQDPFCYFIDDEHSRQLFLGYAVAASRLKTQLDCMNIKPSLETPLFVYLP CGVGGGPGGVAFGLKLLYGDDVHVFFAEPTHSPCMLLGLYSGLHEKISVQDIGLDNQT AADGLAVGRPSGFVGKLIEPLLSGCYTVEDNTLYTLLHMLAVSEDKYLEPSALAGMFG PVQLFSTEEGRRYAQKYKMEHAVHVVWGTGGSMVPKDEMAAYNRIGADLLKKRNEK*" gene complement(2335178..2336524) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" S_feature complement(2336525..2336599) /Source="Nicolas_S_feature" /locus_tag="new_2470927_2471001_c" /HighExp="C90, LBGtran, Diami, dia15, H2O2, dia5, G150, MG 15, GM-0.2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S901" CDS complement(2336600..2337379) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metabolite dehydrogenase, NAD-binding" /protein_id="NP_390259.1" /db_xref="EnsemblGenomes-Gn:BSU23780" /db_xref="EnsemblGenomes-Tr:CAB14310" /db_xref="GOA:P54554" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11746" /db_xref="UniProtKB/Swiss-Prot:P54554" /translation="MKHIAGKRIWITGASGGLGERIAYLCAAEGAHVLLSARREDRLI EIKRKITEEWSGQCEIFPLDVGRLEDIARVRDQIGSIDVLINNAGFGIFETVLDSTLD DMKAMFDVNVFGLIACTKAVLPQMLEQKKGHIINIASQAGKIATPKSSLYSATKHAVL GYSNALRMELSGTGIYVTTVNPGPIQTDFFSIADKGGDYAKNVGRWMLDPDDVAAQIT AAIFTKKREINLPRLMNAGTKLYQLFPALVEKLAGRALMKK*" gene complement(2336600..2337379) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" CDS complement(2337385..2338344) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390260.1" /db_xref="EnsemblGenomes-Gn:BSU23790" /db_xref="EnsemblGenomes-Tr:CAB14311" /db_xref="GOA:P54553" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11745" /db_xref="UniProtKB/Swiss-Prot:P54553" /translation="MTTEDVIAIRVPTPFAVGDVIVYLVKGDALTLIDAGPNTKEAAR ALQEQLAAVNVKLSDIEQVVLTHHHADHAGLLDVFSDEIEVIGHTFNEPYISQNQAFM DWQKRFFQKLLPELGVPFDTGKAEKLIRSAYAFSCTRSLTKSIREGMGIDGLEGWSVL EMPGHAESHIVLFHEKSGRMLGGDLLLANSSSNPILEAPKAGDVRSKPLVDYQRSLRR LSQLDPTIVFPGHGEPITSVQALIEKRFDKQRNRTEDVRRMLDEKPMTAFQVCQQLFP AVYEKELFLTMSETAGHLDVLEAEEAITSYWEGNTVYFKTMKR*" gene complement(2337385..2338344) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" promotor_-10 complement(2338366..2338385) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2338385) /Source="Nicolas_upshifts" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" promotor_-35 complement(2338400..2338407) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2338441..2338448 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2338462..2338748 /Source="Nicolas_S_feature" /locus_tag="new_2472864_2473150" /HighExp="Diami, C90, BC, Paraq, G180, GM 15, Oxctl, S7, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S902" upshifts 2338462 /Source="Nicolas_upshifts" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" promotor_-10 2338464..2338483 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2338478..2338723 /gene="pswI" /locus_tag="BSU_misc_RNA_91" /product="proline T-box riboswitch" /experiment="publication(s) with functional evidences, PMID:21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21233158" gene 2338478..2338723 /gene="pswI" /locus_tag="BSU_misc_RNA_91" CDS 2338749..2339585 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21233158, 28752945, 28824574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21233158, 28752945, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase (NADP-dependent, weak activity)" /protein_id="NP_390261.1" /db_xref="EnsemblGenomes-Gn:BSU23800" /db_xref="EnsemblGenomes-Tr:CAB14312" /db_xref="GOA:P54552" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11744" /db_xref="UniProtKB/Swiss-Prot:P54552" /translation="MKKIGFVGAGSMAEAMINGILQSGITKPEHIYITNRSNDERLIE LKETYSVRPCRDKNEFFTHTDIIILAFKPKDAAESIDSIRPYIKDQLVISVLAGLTIE TIQHYFGRKLAVIRVMPNTSAAIRKSATGFSVSTEASKNDIIAAKALLETIGDATLVE ERHLDAVTAIAGSGPAYVYRYIEAMEKAAQKVGLDKETAKALILQTMAGATDMLLQSG KQPEKLRKEITSPGGTTEAGLRALQDSRFEEAIIHCIEETAKRSAEIKEQFAGAALER HS*" gene 2338749..2339585 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" downshifts 2339583 /Source="Nicolas_upshifts" /id="D1238" /incds=0 /nref=29 /ntot=190 /MaxReadThrough="0.55696" /MaxDrop="3.78131" /score="36.2472665" /energy="-12" /TU="NA" /idTUdmin="U1859" /TUdmin="-1" /isTUend="TRUE" CDS complement(2339626..2341269) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase" /protein_id="NP_390262.2" /db_xref="EnsemblGenomes-Gn:BSU23810" /db_xref="EnsemblGenomes-Tr:CAB14313" /db_xref="GOA:P54551" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG11743" /db_xref="UniProtKB/Swiss-Prot:P54551" /translation="MNWQTKDELLALLTSLVQYESITGSKGEVALAEYLYFILKDKPY FQKHPDDVTLHPMDDGRSFLTALVKKKNVKKTVLLLSHFDVVDIEDYGEFKHMACKPA ELLSSFLEKKELLPERVRRDAESGDWLFGRGTMDMKAGLCIQLSMLERAMNGHFEGNL LLITVPDEEVNSRGMIEAVPALKEMEKKHDITLTACLNAEPMFEKFPGDQQQYFYTGS IGKVLAGFFCKGIETHVGEPFSGLNANLMVSEINRLLELNADYCEKVDGEVTPPPVNL MQKDLKEAYSVQTPHTAVTLFNVLSMKRSASELHQMLLKTAEQAAEEIMSNVRKKTQD FQQFEPFQPIERDVTVLTFDELVSRAKKRAGISETERALNYAFANRGELGDRDFSTKI VSELASLCKEDAPLIVLFYSPPLYPAVSSKDDQLIRNTADQIKHYAAERYGIALREVQ YFPGLSDLSYLQLEKQEVDAYTSNMPLFNRGYSLPSGKNQALYVPVLNVGPAGKDPHK WTERLYMPYSFEVLPDLLSFTISALLKQSESAGQLLREK*" gene complement(2339626..2341269) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" downshifts complement(2339638) /Source="Nicolas_upshifts" /id="D1239" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="2.2598" /MaxDrop="2.55609" /score="14.9380989" /energy="-12" /TU="NA" /idTUdmin="U1861" /TUdmin=0 /isTUend="TRUE" promotor_-35 2341287..2341293 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2341300 /Source="Nicolas_upshifts" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2341307..2341318 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(2341325..2341344) /Source="Nicolas_upshift_promotors" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2341330) /Source="Nicolas_upshifts" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" promotor_-35 2341376..2341383 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2341397..2341416 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2341399 /Source="Nicolas_upshifts" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" CDS 2341441..2342457 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" /EC_number="1.6.99.1" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12660247, 15249051, 15890652, 20011599, 20461254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12660247, 15249051, 15890652, 20011599, 20461254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent flavin oxidoreductase (acting oncinnamaldehyde-related compounds)" /protein_id="NP_390263.1" /db_xref="EnsemblGenomes-Gn:BSU23820" /db_xref="EnsemblGenomes-Tr:CAB14314" /db_xref="GOA:P54550" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023663" /db_xref="PDB:1Z41" /db_xref="PDB:1Z42" /db_xref="PDB:1Z44" /db_xref="PDB:1Z48" /db_xref="SubtiList:BG11742" /db_xref="UniProtKB/Swiss-Prot:P54550" /translation="MARKLFTPITIKDMTLKNRIVMSPMCMYSSHEKDGKLTPFHMAH YISRAIGQVGLIIVEASAVNPQGRITDQDLGIWSDEHIEGFAKLTEQVKEQGSKIGIQ LAHAGRKAELEGDIFAPSAIAFDEQSATPVEMSAEKVKETVQEFKQAAARAKEAGFDV IEIHAAHGYLIHEFLSPLSNHRTDEYGGSPENRYRFLREIIDEVKQVWDGPLFVRVSA SDYTDKGLDIADHIGFAKWMKEQGVDLIDCSSGALVHADINVFPGYQVSFAEKIREQA DMATGAVGMITDGSMAEEILQNGRADLIFIGRELLRDPFFARTAAKQLNTEIPAPVQY ERGW*" gene 2341441..2342457 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" downshifts 2342444 /Source="Nicolas_upshifts" /id="D1240" /incds=0 /nref=42 /ntot=157 /MaxReadThrough="2.79686" /MaxDrop="5.04803" /score="39.119339" /energy="-12.8" /TU="U1862" /idTUdmin="U1862" /TUdmin="-770" /isTUend="FALSE" promotor_-35 2342506..2342515 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2342528..2342543 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2342532 /Source="Nicolas_upshifts" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" CDS 2342567..2343328 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390264.1" /db_xref="EnsemblGenomes-Gn:BSU23830" /db_xref="EnsemblGenomes-Tr:CAB14315" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11741" /db_xref="UniProtKB/Swiss-Prot:P54549" /translation="MKSAWMEKTYTIDGCAFHTQHRKGSSGVTIVFEAGYGTSSETWK PLMADIDDEFGIFTYDRAGIGKSGQSRAKRTADQQVKELESLLKAADVKPPYLAVSHS YGAVITGLWACKNKHDIIGMVLLDPALGDCASFTFIPEEMHKSHTRKMMLEGTHAEFS KSLQELKKRQVHLGNMPLLVLSSGERTEKFAAEQEWQNLHSSILSLSNQSGWIQAKNS SHNIHHDEPHIVHLAIYDVWCAACQQAAPLYQAVN*" gene 2342567..2343328 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" downshifts 2343236 /Source="Nicolas_upshifts" /id="D1241" /incds=1 /nref=21 /ntot=204 /MaxReadThrough="3.34804" /MaxDrop="3.21955" /score="0.451826768" /energy="-11.2" /TU="U1863" /idTUdmin="U1862" /TUdmin=22 /isTUend="TRUE" downshifts 2343324 /Source="Nicolas_upshifts" /id="D1242" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="1.34151" /MaxDrop="3.85711" /score="0.451826768" /energy="-11.2" /TU="NA" /idTUdmin="U1863" /TUdmin=0 /isTUend="TRUE" S_feature complement(2343356..2343556) /Source="Nicolas_S_feature" /locus_tag="new_2477758_2477958_c" /HighExp="B60, S5, Etha, S4, B36, BMM, Heat, S3, S2, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.21631400000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S903" CDS complement(2343372..2343497) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33* pseudogene" /translation="CTETGDRNYITTKNKRTNPDRLELKKYSPRLKKYTLHRETK*" gene complement(2343372..2343497) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /pseudo downshifts complement(2343399) /Source="Nicolas_upshifts" /id="D1243" /incds=0 /nref=187 /ntot=264 /MaxReadThrough="3.91531" /MaxDrop="7.65732" /score="5.23287853" /energy="-8.8" /TU="U1864" /idTUdmin="U1865" /TUdmin=1 /isTUend="TRUE" CDS complement(2343490..2343522) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 19648245, 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33C pseudogene" /db_xref="PSEUDO:CCQ48601.1" /translation="MRVNVTLALH*" gene complement(2343490..2343522) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /pseudo promotor_-10 complement(2343550..2343569) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2343556) /Source="Nicolas_upshifts" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" promotor_-35 complement(2343582..2343589) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2343604..2344527) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" /EC_number="3.1.26.11" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 12941704, 16336119, 17005971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12941704, 16336119, 17005971; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease Z" /protein_id="NP_390265.1" /db_xref="EnsemblGenomes-Gn:BSU23840" /db_xref="EnsemblGenomes-Tr:CAB14316" /db_xref="GOA:P54548" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR013471" /db_xref="InterPro:IPR036866" /db_xref="PDB:1Y44" /db_xref="PDB:2FK6" /db_xref="PDB:4GCW" /db_xref="SubtiList:BG11740" /db_xref="UniProtKB/Swiss-Prot:P54548" /translation="MELLFLGTGAGIPAKARNVTSVALKLLEERRSVWLFDCGEATQH QILHTTIKPRKIEKIFITHMHGDHVYGLPGLLGSRSFQGGEDELTVYGPKGIKAFIET SLAVTKTHLTYPLAIQEIEEGIVFEDDQFIVTAVSVIHGVEAFGYRVQEKDVPGSLKA DVLKEMNIPPGPVYQKIKKGETVTLEDGRIINGNDFLEPPKKGRSVVFSGDTRVSDKL KELARDCDVLVHEATFAKEDRKLAYDYYHSTTEQAAVTAKEARAKQLILTHISARYQG DASLELQKEAVDVFPNSVAAYDFLEVNVPRG*" gene complement(2343604..2344527) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" promotor_-10 complement(2344553..2344572) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2344566) /Source="Nicolas_upshifts" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" promotor_-35 complement(2344586..2344591) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2344665..2344672 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2344686..2344705 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2344688..2344753 /Source="Nicolas_S_feature" /locus_tag="new_2479090_2479155" /HighExp="dia5, C90, MG 5, Lbexp, MG t5, MG 45, M9-exp, GM 90, GM 120, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S904" upshifts 2344688 /Source="Nicolas_upshifts" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" CDS 2344754..2346223 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" /EC_number="1.1.1.49" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1704005, 19779711, 26129872" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1704005, 19779711, 26129872; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate 1-dehydrogenase (NADP-dependent)" /protein_id="NP_390266.2" /db_xref="EnsemblGenomes-Gn:BSU23850" /db_xref="EnsemblGenomes-Tr:CAB14317" /db_xref="GOA:P54547" /db_xref="InterPro:IPR001282" /db_xref="InterPro:IPR019796" /db_xref="InterPro:IPR022674" /db_xref="InterPro:IPR022675" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11739" /db_xref="UniProtKB/Swiss-Prot:P54547" /translation="MKTNQQPKAVIVIFGATGDLAKRKLYPSIHRLYQNGQIGEEFAV VGVGRRPWSNEDLRQTVKTSISSSADKHIDDFTSHFYYHPFDVTNPGSYQELNVLLNQ LEDTYQIPNNRMFYLAMAPEFFGTIAKTLKSEGVTATTGWSRLVIEKPFGHDLPSAQA LNKEIREAFTEDQIYRIDHYLGKQMVQNIEVIRFANAIFEPLWTNRYISNIQITSSES LGVEDRARYYEKSGALRDMVQNHIMQMVALLAMEPPIKLNTEEIRSEKVKVLRALRPI AKDEVDEYFVRGQYHAGEIDGVPVPAYTDEDNVAPDSNTETFVAGKLLIDNFRWAGVP FYIRTGKRMKEKSTKIVVQFKDIPMNLYYGNENNMNPNLLVIHIQPDEGITLYLNAKK LGGAAHAQPIKLDYCSNCNDELNTPEAYEKLIHDCLLGDATNFAHWDEVALSWSFVDS ISETWAANKTLSPNYESGSMGPKESDDLLVKDGLHWWNI*" gene 2344754..2346223 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" downshifts 2346206 /Source="Nicolas_upshifts" /id="D1244" /incds=0 /nref=206 /ntot=286 /MaxReadThrough="3.46838" /MaxDrop="7.76173" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-90" /isTUend="FALSE" downshifts 2346274 /Source="Nicolas_upshifts" /id="D1245" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="2.5392" /MaxDrop="4.74183" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-22" /isTUend="TRUE" CDS complement(2346348..2347757) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" /EC_number="1.1.1.44" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 15755726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 15755726; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP+-dependent 6-P-gluconate dehydrogenase" /protein_id="NP_390267.2" /db_xref="EnsemblGenomes-Gn:BSU23860" /db_xref="EnsemblGenomes-Tr:CAB14318" /db_xref="GOA:P80859" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11738" /db_xref="UniProtKB/Swiss-Prot:P80859" /translation="MSKQQIGVIGLAVMGKNLALNIESRGFSVSVYNRSSSKTEEFLQ EAKGKNVVGTYSIEEFVQSLETPRKILLMVKAGTATDATIQSLLPHLEKDDILIDGGN TYYKDTQRRNKELAESGIHFIGTGVSGGEEGALKGPSIMPGGQKEAHELVKPILEAIS AKVDGEPCTTYIGPDGAGHYVKMVHNGIEYGDMQLISESYFILKQVLGLSADELHEVF AEWNKGELDSYLIEITADIFTKKDEETGKPLVDVILDKAGQKGTGKWTSQSALDLGVP LPIITESVFARFISAMKEERVKASGLLSGPEVKPVTENKEELIEAVRKALFMSKICSY AQGFAQMKAASEEYNWDLKYGEIAMIFRGGCIIRAAFLQKIKEAYDREPELDNLLLDS YFKNIVESYQGALRQVISLAVAQGVPVPSFSSALAYYDSYRTAVLPANLIQAQRDYFG AHTYERTDKEGIFHTEWMK*" gene complement(2346348..2347757) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" downshifts complement(2346365) /Source="Nicolas_upshifts" /id="D1246" /incds=0 /nref=220 /ntot=361 /MaxReadThrough="1.88983" /MaxDrop="8.82894" /score="24.3727084" /energy="-18" /TU="NA" /idTUdmin="U1867" /TUdmin="-15" /isTUend="TRUE" downshifts complement(2346438) /Source="Nicolas_upshifts" /id="D1247" /incds=1 /nref=1 /ntot=36 /MaxReadThrough="8.40595" /MaxDrop="2.3555" /score="24.3727084" /energy="-18" /TU="U1867" /idTUdmin="U1867" /TUdmin="-88" /isTUend="FALSE" misc_feature complement(2347821..2347839) /Source="Nicolas_upshift_promotors" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2347823) /Source="Nicolas_upshifts" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" CDS complement(2347867..2349111) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" /EC_number="2.7.7.7" /function="16.6: Maintain" /function="16.5: Explore" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-damage lesion bypass DNA polymerase" /protein_id="NP_390268.2" /db_xref="EnsemblGenomes-Gn:BSU23870" /db_xref="EnsemblGenomes-Tr:CAB14319" /db_xref="GOA:P54545" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017061" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR024728" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11737" /db_xref="UniProtKB/Swiss-Prot:P54545" /translation="MPGKSRIIFHIDMNSFYASVEMAYDPALRGKPVAVAGNVKERKG IVVTCSYEARARGVKTTMPVWQAKRHCPELIVLPPNFDRYRNSSRAMFTILREYTDLV EPVSIDEGYMDMTDTPYSSRALETAKEIQSRLQKELLLPSSIGIAPNKFLAKMASDMK KPLGITILRKRQVPDILWPLPVGEMHGVGKKTAEKLKGLGIHTIGELAAADEHSLKRL LGINGPRLKNKANGIHHAPVDPERIYEFKSVGNSSTLSHDSSDEEELLGVFRKLAASV SDRLQRKEVMASKLFIMIRYADWRTITRSTTLRNPIDQKNDILKEAEHLFFKHWNKNP VRLLGITGTDLVEKEQAYKQLDLFSFNEDAKDEPIQQMMEKLNKKYGTKLIRKGATLK KEESKTKGTSFNKDFFQDEKKS*" gene complement(2347867..2349111) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" S_feature complement(2349112..2349386) /Source="Nicolas_S_feature" /locus_tag="new_2483514_2483788_c" /HighExp="M40t90, Sw, M40t45, H2O2, C30, Cold, Etha, C90, Diami, BC" /AntisenseName="yqzJ" /AntisenseCor="0.48883700687558601" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S905" promotor_-35 2349132..2349139 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2349153..2349172 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2349153 /Source="Nicolas_upshifts" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" CDS 2349184..2349471 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" /experiment="publication(s) with functional evidences, PMID:19779460, 21383133, 22720735, 25313395, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19779460, 21383133, 22720735, 25313395, 25903689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of OxaAB translation" /protein_id="YP_054586.1" /db_xref="EnsemblGenomes-Gn:BSU23880" /db_xref="EnsemblGenomes-Tr:CAE01460" /db_xref="GOA:Q7WY64" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG14191" /db_xref="UniProtKB/Swiss-Prot:Q7WY64" /translation="MTMFVESINDVLFLVDFFTIILPALTAIGIAFLLRECRAGEQWK SKRTDEHQTVFHINRTDFLIIIYHRITTWIRKVFRMNSPVNDEEDAGSLLL*" gene 2349184..2349471 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" promotor_-10 complement(2349368..2349387) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-10" upshifts complement(2349388) /Source="Nicolas_upshifts" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" promotor_-35 complement(2349403..2349406) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-35" CDS 2349502..2350329 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_390269.1" /db_xref="EnsemblGenomes-Gn:BSU23890" /db_xref="EnsemblGenomes-Tr:CAB14320" /db_xref="GOA:P54544" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG11736" /db_xref="UniProtKB/Swiss-Prot:P54544" /translation="MLKTYQKLLAMGIFLIVLCSGNAAFAATNQVGGLSNVGFFHDYL IEPFSALLKGVAGLFHGEYGLSIILVTIIVRIVVLPLFVNQFKKQRIFQEKMAVIKPQ VDSIQVKLKKTKDPEKQKELQMEMMKLYQEHNINPLAMGCLPMLIQSPIMIGLYYAIR STPEIASHSFLWFSLGQSDILMSLSAGIMYFVQAYIAQKLSAKYSAVPQNPAAQQSAK LMVFIFPVMMTIFSLNVPAALPLYWFTSGLFLTVQNIVLQMTHHKSKKTAALTESVK* " gene 2349502..2350329 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" downshifts 2350146 /Source="Nicolas_upshifts" /id="D1248" /incds=1 /nref=4 /ntot=125 /MaxReadThrough="5.05074" /MaxDrop="3.49092" /score="-5.67811369" /energy="-7.6" /TU="U1868" /idTUdmin="U1868" /TUdmin="-176" /isTUend="FALSE" downshifts 2350322 /Source="Nicolas_upshifts" /id="D1249" /incds=0 /nref=71 /ntot=229 /MaxReadThrough="1.09826" /MaxDrop="6.56698" /score="-5.67811369" /energy="-7.6" /TU="NA" /idTUdmin="U1868" /TUdmin=0 /isTUend="TRUE" S_feature complement(2350334..2351254) /Source="Nicolas_S_feature" /locus_tag="new_2484736_2485656_c" /HighExp="LoTm, B36, M0t90, M40t90, Lbstat, M9-stat, T1.30H, B60, LBGtran, BT" /AntisenseName="yqjF" /AntisenseCor="0.18628881890353799" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S906" downshifts complement(2350377) /Source="Nicolas_upshifts" /id="D1250" /incds=0 /nref=170 /ntot=248 /MaxReadThrough="0.24428" /MaxDrop="6.31082" /score="18.1943524" /energy="-12.4" /TU="NA" /idTUdmin="U1871" /TUdmin="-1" /isTUend="TRUE" promotor_-35 2350447..2350453 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2350467..2350485 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2350476 /Source="Nicolas_upshifts" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" CDS 2350509..2351237 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390270.3" /db_xref="EnsemblGenomes-Gn:BSU23900" /db_xref="EnsemblGenomes-Tr:CAB14321" /db_xref="InterPro:IPR018644" /db_xref="InterPro:IPR023375" /db_xref="SubtiList:BG11735" /db_xref="UniProtKB/Swiss-Prot:P54543" /translation="MTERFQQKNISVPDGIWIMRQTWNDVLFAHWPVDVSILRALVPS VLELDTYNGQAWISMLPFMLTNLRARYLPVIPGARAFPELNLRTYVTYKGKPGIYFFS LDADHRLAVLGARTFFHLPYFYADMKSEKNGDAIDYVSKRKNDKEAAFHAAYRPISAP FTAEKDSLDYWLTERYRLYTTYRNKLYYEDIHHHPWLLQNAEAEISVNTVTDAHGITL PESDPLLHYAKKQDVLFWPLRKWS*" gene 2350509..2351237 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" CDS complement(2351278..2352393) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase or deacylase" /protein_id="NP_390271.2" /db_xref="EnsemblGenomes-Gn:BSU23910" /db_xref="EnsemblGenomes-Tr:CAB14322" /db_xref="GOA:P54542" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR010162" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11734" /db_xref="UniProtKB/Swiss-Prot:P54542" /translation="MVNEKRLLEEFLELVQIDSETKHEAEICKVLKRKFSDLGVDVKE DDTMDITGHGAGNLICTLKGTKQTDTIYFTSHMDTVVPGNGVKPVVENGYVKTDGTTI LGADDKAGLAAMFEAIKVLKEENIEHGTIEFIITVGEESGLIGAKALDRSMITASYGY ALDSDGKVGNIIVAAPTQAKVRAAIFGKTAHAGVEPEKGISAITIASKAISKMPLGRI DEETTANIGRFEGGTQTNIVCDEVHILAEARSLVPEKMEAQVQKMKAAFEEAAADMGG RAEVEIEVMYPGFKYQDGDQVVEIAKKAAAKIGRPSELQTSGGGSDANVIAGHGIPTV NLAVGYEQIHTKNEKMPIEELVKTAEMVVAIIEEAAK*" gene complement(2351278..2352393) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" downshifts complement(2351299) /Source="Nicolas_upshifts" /id="D1251" /incds=0 /nref=23 /ntot=203 /MaxReadThrough="3.90071" /MaxDrop="3.95711" /score="11.6635037" /energy="-10.6" /TU="U1871" /idTUdmin="U1871" /TUdmin="-923" /isTUend="FALSE" CDS complement(2352411..2353934) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" /EC_number="6.4.1.3" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative propionyl-CoA carboxylase beta chain" /protein_id="NP_390272.2" /db_xref="EnsemblGenomes-Gn:BSU23920" /db_xref="EnsemblGenomes-Tr:CAB14323" /db_xref="GOA:P54541" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG11733" /db_xref="UniProtKB/Swiss-Prot:P54541" /translation="MNEHMDHFYTKRKQAEEGGGREKLAQQRQKGKLTARERIIFLLD QDSFIELHPFMESQVLTREQRMLGDGVVTGYGTIDGRSVYVFAQDFTVYGGALGETHA RKICALMDLAAKNKAPIIGLNDSGGARIQEGVLSLDGYGHIFYRNVLYSGVIPQISVI LGPCAGGAVYSPALTDFIFMAEQTGRMFITGPKVIEKVTGEQVDAESLGGAGIHNAVS GNAHFSGHTEKEVLTGVRKLLSYLPLNGRTTEPKPEKEASRPLLNRLVPADTTKPYDV RKVIRELADPQSFFEIQPFFAKNIVIGFARLGEKAIGIVASQPKHLAGSLTIDAADKA ARFIRFCDAFDIPLLTVEDVPGFLPGIQQEHNGIIRHGAKLLFAYAEATVPKVTLIIR KAYGGAYVAMNSKAIGADLVFAWPNAEIAVMGPEGAASILYEKEIKASADPQKTKREK TAEYKKQNAGPYKAAACGMVDDIILPEESRGRLIQAFHMLTHKTEERPKKKHGNIPL* " gene complement(2352411..2353934) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" promotor_-10 complement(2353517..2353536) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2353539) /Source="Nicolas_upshifts" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" promotor_-35 complement(2353551..2353555) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2353927..2354349) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" /EC_number="5.1.99.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methylmalonyl-CoA epimerase" /protein_id="NP_390273.2" /db_xref="EnsemblGenomes-Gn:BSU23930" /db_xref="EnsemblGenomes-Tr:CAB14324" /db_xref="GOA:P54540" /db_xref="InterPro:IPR017515" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11732" /db_xref="UniProtKB/Swiss-Prot:P54540" /translation="MNRLDHIGIAVFSIKDARSFYENVLGLAFLHQETVEEQKVNVAF FQAGSVKLELIEPLTADSPVHLFLEKKGQGLHHIAFLCNCLSEQLQALSDQHVQLIDR FPRQGANGKKIAFISPRETNGVLVELCEPKGDQHNEHE*" gene complement(2353927..2354349) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" promotor_-35 2354378..2354385 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2354399..2354418 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2354413..2354566 /Source="Nicolas_S_feature" /locus_tag="new_2488815_2488968" /HighExp="LPhT, Etha, dia15, Salt, M9-stat, LBGstat, Heat, BC, T-0.40H, HiOs" /AntisenseName="yqjB" /AntisenseCor="-0.57221813594264503" /AntisenseRegPval="-24.1" /CDS_PredictionProba="0.99822200000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S907" upshifts 2354413 /Source="Nicolas_upshifts" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" downshifts 2354523 /Source="Nicolas_upshifts" /id="D1252" /incds=0 /nref=1 /ntot=140 /MaxReadThrough="3.88708" /MaxDrop="3.25163" /score="3.10927996" /energy="-7" /TU="U1872" /idTUdmin="U1872" /TUdmin="-638" /isTUend="FALSE" CDS complement(2354551..2355081) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" /EC_number="2.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative L,D-transpeptidase" /protein_id="NP_390274.1" /db_xref="EnsemblGenomes-Gn:BSU23940" /db_xref="EnsemblGenomes-Tr:CAB14325" /db_xref="GOA:P54539" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG11731" /db_xref="UniProtKB/Swiss-Prot:P54539" /translation="MRFFLCSIFMMISPIWPLGENPLPGDPYVIVNKRTNELAVILDN KVEGVYSVATGKTDDLTPEGEFSVTVKAENPYYRKKNIEGGSPDNPLGARWIGFDAKG TDGRIYGIHGTNREESVGKFVSNGCIRMHNDEVVHLFQTIPVGTRVLITDDNRSFEEI AIEHKALIKKQDIPIE*" gene complement(2354551..2355081) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" S_feature 2354568..2355203 /Source="Nicolas_S_feature" /locus_tag="new_2488970_2489605" /HighExp="LPhT, H2O2, BC, Salt, dia15, M9-stat, Heat, LBGstat, T5.0H, Etha" /AntisenseName="yqjB" /AntisenseCor="-0.31126010332536502" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S908" promotor_-10 complement(2355098..2355109) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2355105) /Source="Nicolas_upshifts" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" promotor_-35 complement(2355124..2355130) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2355133..2356101) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390275.2" /db_xref="EnsemblGenomes-Gn:BSU23950" /db_xref="EnsemblGenomes-Tr:CAB14326" /db_xref="GOA:P54538" /db_xref="InterPro:IPR010343" /db_xref="InterPro:IPR021062" /db_xref="SubtiList:BG11730" /db_xref="UniProtKB/Swiss-Prot:P54538" /translation="MFKIGYRTIKTALGTALAIYISQLLHLQNFASAGIITILCIQIT QKRSLQASWARFSACCLAIAFSYLFFELIGYHPFVIGALLLIFIPITVLLKINEGIVT SSVIILHLYMSGGITPTFIWNEVQLITVGIGVALLMNLYMPSLDRKLIAYRKKIEDNF AVIFAEIERYLLTGEQDWSGKEIPETHQLITEAKNLAYRDVQNHILRYENLHYHYFKM REKQFEIIERLLPKVTSISITVDQGKMIAEFIHDLREAIHPGNTAYKFLKRLADMRKE FEEMPLPATREEFEARAALFHLLGEMEQYLVIKSYFKGIKAQKSLG*" gene complement(2355133..2356101) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" downshifts complement(2355149) /Source="Nicolas_upshifts" /id="D1253" /incds=0 /nref=79 /ntot=223 /MaxReadThrough="2.22356" /MaxDrop="3.94894" /score="1.98299685" /energy="-14.1" /TU="NA" /idTUdmin="U1874" /TUdmin=0 /isTUend="TRUE" CDS complement(2356172..2356894) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (ATP-binding protein)" /protein_id="NP_390276.1" /db_xref="EnsemblGenomes-Gn:BSU23960" /db_xref="EnsemblGenomes-Tr:CAB14327" /db_xref="GOA:P54537" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11729" /db_xref="UniProtKB/Swiss-Prot:P54537" /translation="MIKVEKLSKSFGKHEVLKNISTTIAEGEVVAVIGPSGSGKSTFL RCLNLLEKPNGGTITIKDTEITKPKTNTLKVRENIGMVFQHFHLFPHKTVLENIMYAP VNVKKESKQAAQEKAEDLLRKVGLFEKRNDYPNRLSGGQKQRVAIARALAMNPDIMLF DEPTSALDPEMVKEVLQVMKELVETGMTMVIVTHEMGFAKEVADRVLFMDQGMIVEDG NPKEFFMSPKSKRAQDFLEKIL*" gene complement(2356172..2356894) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" downshifts complement(2356183) /Source="Nicolas_upshifts" /id="D1254" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="4.81216" /MaxDrop="4.0342" /score="0.346345754" /energy="-7" /TU="U1874" /idTUdmin="U1874" /TUdmin="-1034" /isTUend="FALSE" CDS complement(2356887..2357546) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (permease)" /protein_id="NP_390277.1" /db_xref="EnsemblGenomes-Gn:BSU23970" /db_xref="EnsemblGenomes-Tr:CAB14328" /db_xref="GOA:P54536" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11728" /db_xref="UniProtKB/Swiss-Prot:P54536" /translation="MNLDFSATIPQIPFILEGLAITLKIVVVSAIIGLILGIVLSLCK ISTFRPFIWIADFYTSVFRGTPLVLQLMIVYFGLPQLLGFQIDQFWAAVVALSLNSAA YVSEIIRAGINAIDKGQKEAAVALGVPYGKMMKDLLLPQAFKNISPAIVNELITLTKE SAIVTVIGLGDVMRRAYQAGAATYNYLEPLIIAGLIYYVLVLILTFIGKAVERKLKSN D*" gene complement(2356887..2357546) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" S_feature complement(2357547..2357626) /Source="Nicolas_S_feature" /locus_tag="new_2491949_2492028_c" /HighExp="S1, S2, ferm, MG 15, Fru, Glu, BMM, S3, UNK1, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S909" CDS complement(2357627..2358394) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter binding lipoprotein" /protein_id="NP_390278.1" /db_xref="EnsemblGenomes-Gn:BSU23980" /db_xref="EnsemblGenomes-Tr:CAB14329" /db_xref="GOA:P54535" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11727" /db_xref="UniProtKB/Swiss-Prot:P54535" /translation="MKKWLLLLVAACITFALTACGSSNSGSESGKKKLIMGTSADYKP FEYKEGDNIVGFDVELAKALAKKAGYEIEVQDMDFNSLITALKSKQVDLVLSGMTPTP ERKKQVDFSDVYYTANHMIVSKKDSGIQSLKDLKGKTVGVQLGSIQEEKGKELSPEYG FKTEDRNRISDLVQEIKSDRFDAAIIEDIVAEGYFKSNDDLQGFVIPDAKAEEAGSAI AFRKDSELTDKFNKALKEMEDNGELEKLKKKWFTGEK*" gene complement(2357627..2358394) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" promotor_-10 complement(2358444..2358463) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2358459) /Source="Nicolas_upshifts" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" promotor_-35 complement(2358478..2358485) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2358662..2359099) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" /experiment="publication(s) with functional evidences, PMID:21749987, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21749987, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin B (de-bacillithiolation)" /protein_id="NP_390279.1" /db_xref="EnsemblGenomes-Gn:BSU23990" /db_xref="EnsemblGenomes-Tr:CAB14330" /db_xref="InterPro:IPR009474" /db_xref="SubtiList:BG11726" /db_xref="UniProtKB/Swiss-Prot:P54534" /translation="MNMDFNLFMNDIVRQARQEITAAGYTELKTAEEVDEALTKKGTT LVMVNSVCGCAGGIARPAAYHSVHYDKRPDQLVTVFAGQDKEATARARDYFEGYPPSS PSFAILKDGKIMKMVERHEIEGHEPMAVVAKLQEAFEEYCEEV*" gene complement(2358662..2359099) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" downshifts complement(2358671) /Source="Nicolas_upshifts" /id="D1255" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="3.9242" /MaxDrop="7.06654" /score="21.489397" /energy="-11.8" /TU="U1875" /idTUdmin="U1875" /TUdmin="-200" /isTUend="FALSE" promotor_-10 complement(2359123..2359142) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-10" upshifts complement(2359144) /Source="Nicolas_upshifts" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" promotor_-35 complement(2359157..2359164) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-35" promotor_-35 2359197..2359203 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2359216 /Source="Nicolas_upshifts" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" promotor_-10 2359218..2359236 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2359260..2360153 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" /EC_number="2.7.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7961792, 8098708, 10220166, 17114254, 17535816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipid kinase BmrU" /protein_id="NP_390280.2" /db_xref="EnsemblGenomes-Gn:BSU24000" /db_xref="EnsemblGenomes-Tr:CAB14331" /db_xref="GOA:P39074" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG10302" /db_xref="UniProtKB/Swiss-Prot:P39074" /translation="MSHRKALLIHNGNAGNKNIEKALGAVVPVLSHHLDEVIIKQTKK KDDAYHFCRSIDDSVDTVFILGGDGTIHQCINAISALERKPAVGILPGGTCNDFSRVL GIPQNLAKAAEALMAGKKTSVDVCQMNDRYFLNFWGIGLIAETSNQINETEKALLGKI SYFTSALRTVSSAASFPMTLKIDGEEIKEEAVMLLVMNGQYIGTNRIPLPDASIEDGL LDVLICRNTNLTALRELMSMEQGSIDRFTGELSYVQASRIEIETDTAKKADMDGEVYT HTPAVIQVLPQHIDMLVPANE*" gene 2359260..2360153 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" promotor_-35 2360186..2360193 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2360209..2360228 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2360217 /Source="Nicolas_upshifts" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" CDS 2360254..2361423 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10200972, 10961951, 11321573, 15849754, 16850406, 25756668" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 10961951, 11321573, 15849754, 16850406, 25756668; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_390281.2" /db_xref="EnsemblGenomes-Gn:BSU24010" /db_xref="EnsemblGenomes-Tr:CAB14332" /db_xref="GOA:P33449" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10303" /db_xref="UniProtKB/Swiss-Prot:P33449" /translation="MEKKNITLTILLTNLFIAFLGIGLVIPVTPTIMNELHLSGTAVG YMVACFAITQLIVSPIAGRWVDRFGRKIMIVIGLLFFSVSEFLFGIGKTVEMLFISRM LGGISAAFIMPGVTAFIADITTIKTRPKALGYMSAAISTGFIIGPGIGGFLAEVHSRL PFFFAAAFALLAAILSILTLREPERNPENQEIKGQKTGFKRIFAPMYFIAFLIILISS FGLASFESLFALFVDHKFGFTASDIAIMITGGAIVGAITQVVLFDRFTRWFGEIHLIR YSLILSTSLVFLLTTVHSYVAILLVTVTVFVGFDLMRPAVTTYLSKIAGNEQGFAGGM NSMFTSIGNVFGPIIGGMLFDIDVNYPFYFATVTLAIGIALTIAWKAPAHLKAST*" gene 2360254..2361423 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" downshifts 2361406 /Source="Nicolas_upshifts" /id="D1256" /incds=0 /nref=6 /ntot=31 /MaxReadThrough="4.82186" /MaxDrop="5.02667" /score="-1.94257488" /energy="-18" /TU="U1876,U1877" /idTUdmin="U1876" /TUdmin="-924" /isTUend="FALSE" CDS 2361496..2362332 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11201751, 11839496, 12682015, 14985361, 18658145, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11201751, 11839496, 12682015, 14985361, 18658145, 21690368; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family)" /protein_id="NP_390282.2" /db_xref="EnsemblGenomes-Gn:BSU24020" /db_xref="EnsemblGenomes-Tr:CAB14333" /db_xref="GOA:P39075" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="PDB:1BOW" /db_xref="PDB:1EXI" /db_xref="PDB:1EXJ" /db_xref="PDB:1R8E" /db_xref="PDB:2BOW" /db_xref="PDB:3D6Y" /db_xref="PDB:3D6Z" /db_xref="PDB:3D70" /db_xref="PDB:3D71" /db_xref="PDB:3IAO" /db_xref="PDB:3Q1M" /db_xref="PDB:3Q2Y" /db_xref="PDB:3Q3D" /db_xref="PDB:3Q5P" /db_xref="PDB:3Q5R" /db_xref="PDB:3Q5S" /db_xref="SubtiList:BG10304" /db_xref="UniProtKB/Swiss-Prot:P39075" /translation="MKESYYSIGEVSKLANVSIKALRYYDKIDLFKPAYVDPDTSYRY YTDSQLIHLDLIKSLKYIGTPLEEMKKAQDLEMEELFAFYTEQERQIREKLDFLSALE QTISLVKKRMKRQMEYPALGEVFVLDEEEIRIIQTEAEGIGPENVLNASYSKLKKFIE SADGFTNNSYGATFSFQPYTSIDEMTYRHIFTPVLTNKQISSITPDMEITTIPKGRYA CIAYNFSPEHYFLNLQKLIKYIADRQLTVVSDVYELIIPIHYSPKKQEEYRVEMKIRI AE*" gene 2361496..2362332 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" downshifts 2362330 /Source="Nicolas_upshifts" /id="D1257" /incds=0 /nref=5 /ntot=156 /MaxReadThrough="4.1979" /MaxDrop="4.72542" /score="5.00815505" /energy="-15.7" /TU="NA" /idTUdmin="U1876" /TUdmin=0 /isTUend="TRUE" downshifts complement(2362394) /Source="Nicolas_upshifts" /id="D1258" /incds=0 /nref=15 /ntot=247 /MaxReadThrough="3.01431" /MaxDrop="6.04069" /score="8.5296919" /energy="-16.8" /TU="U1879" /idTUdmin="U1878" /TUdmin="-10" /isTUend="TRUE" CDS complement(2362394..2363668) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" /EC_number="2.3.1.168" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E2 subunit (lipoamide acyltransferase)" /protein_id="NP_390283.1" /db_xref="EnsemblGenomes-Gn:BSU24030" /db_xref="EnsemblGenomes-Tr:CAB14334" /db_xref="GOA:P37942" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10305" /db_xref="UniProtKB/Swiss-Prot:P37942" /translation="MAIEQMTMPQLGESVTEGTISKWLVAPGDKVNKYDPIAEVMTDK VNAEVPSSFTGTITELVGEEGQTLQVGEMICKIETEGANPAEQKQEQPAASEAAENPV AKSAGAADQPNKKRYSPAVLRLAGEHGIDLDQVTGTGAGGRITRKDIQRLIETGGVQE QNPEELKTAAPAPKSASKPEPKEETSYPASAAGDKEIPVTGVRKAIASNMKRSKTEIP HAWTMMEVDVTNMVAYRNSIKDSFKKTEGFNLTFFAFFVKAVAQALKEFPQMNSMWAG DKIIQKKDINISIAVATEDSLFVPVIKNADEKTIKGIAKDITGLAKKVRDGKLTADDM QGGTFTVNNTGSFGSVQSMGIINYPQAAILQVESIVKRPVVMDNGMIAVRDMVNLCLS LDHRVLDGLVCGRFLGRVKQILESIDEKTSVY*" gene complement(2362394..2363668) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" CDS complement(2363691..2364674) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" /EC_number="1.2.4.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390284.1" /db_xref="EnsemblGenomes-Gn:BSU24040" /db_xref="EnsemblGenomes-Tr:CAB14335" /db_xref="GOA:P37941" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10306" /db_xref="UniProtKB/Swiss-Prot:P37941" /translation="MSVMSYIDAINLAMKEEMERDSRVFVLGEDVGRKGGVFKATAGL YEQFGEERVMDTPLAESAIAGVGIGAAMYGMRPIAEMQFADFIMPAVNQIISEAAKIR YRSNNDWSCPIVVRAPYGGGVHGALYHSQSVEAIFANQPGLKIVMPSTPYDAKGLLKA AVRDEDPVLFFEHKRAYRLIKGEVPADDYVLPIGKADVKREGDDITVITYGLCVHFAL QAAERLEKDGISAHVVDLRTVYPLDKEAIIEAASKTGKVLLVTEDTKEGSIMSEVAAI ISEHCLFDLDAPIKRLAGPDIPAMPYAPTMEKYFMVNPDKVEAAMRELAEF*" gene complement(2363691..2364674) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" CDS complement(2364688..2365680) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" /EC_number="1.2.4.4" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390285.1" /db_xref="EnsemblGenomes-Gn:BSU24050" /db_xref="EnsemblGenomes-Tr:CAB14336" /db_xref="GOA:P37940" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR034616" /db_xref="SubtiList:BG10307" /db_xref="UniProtKB/Swiss-Prot:P37940" /translation="MSTNRHQALGLTDQEAVDMYRTMLLARKIDERMWLLNRSGKIPF VISCQGQEAAQVGAAFALDREMDYVLPYYRDMGVVLAFGMTAKDLMMSGFAKAADPNS GGRQMPGHFGQKKNRIVTGSSPVTTQVPHAVGIALAGRMEKKDIAAFVTFGEGSSNQG DFHEGANFAAVHKLPVIFMCENNKYAISVPYDKQVACENISDRAIGYGMPGVTVNGND PLEVYQAVKEARERARRGEGPTLIETISYRLTPHSSDDDDSSYRGREEVEEAKKSDPL LTYQAYLKETGLLSDEIEQTMLDEIMAIVNEATDEAENAPYAAPESALDYVYAK*" gene complement(2364688..2365680) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" CDS complement(2365702..2367126) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" /EC_number="1.8.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E3 subunit (dihydrolipoamide dehydrogenase)" /protein_id="NP_390286.2" /db_xref="EnsemblGenomes-Gn:BSU24060" /db_xref="EnsemblGenomes-Tr:CAB14337" /db_xref="GOA:P54533" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11725" /db_xref="UniProtKB/Swiss-Prot:P54533" /translation="MATEYDVVILGGGTGGYVAAIRAAQLGLKTAVVEKEKLGGTCLH KGCIPSKALLRSAEVYRTAREADQFGVETAGVSLNFEKVQQRKQAVVDKLAAGVNHLM KKGKIDVYTGYGRILGPSIFSPLPGTISVERGNGEENDMLIPKQVIIATGSRPRMLPG LEVDGKSVLTSDEALQMEELPQSIIIVGGGVIGIEWASMLHDFGVKVTVIEYADRILP TEDLEISKEMESLLKKKGIQFITGAKVLPDTMTKTSDDISIQAEKDGETVTYSAEKML VSIGRQANIEGIGLENTDIVTENGMISVNESCQTKESHIYAIGDVIGGLQLAHVASHE GIIAVEHFAGLNPHPLDPTLVPKCIYSSPEAASVGLTEDEAKANGHNVKIGKFPFMAI GKALVYGESDGFVKIVADRDTDDILGVHMIGPHVTDMISEAGLAKVLDATPWEVGQTI HPHPTLSEAIGEAALAADGKAIHF*" gene complement(2365702..2367126) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" CDS complement(2367147..2368238) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" /EC_number="2.7.2.-" /EC_number="2.7.2.7" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain fatty-acid kinase" /protein_id="NP_390287.2" /db_xref="EnsemblGenomes-Gn:BSU24070" /db_xref="EnsemblGenomes-Tr:CAB14338" /db_xref="GOA:P54532" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR011245" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG11724" /db_xref="UniProtKB/Swiss-Prot:P54532" /translation="MKVLHDEKRILTINPGSTSTKIGVFHNERSIFEKTLRHNIEELQ RFDRIIDQYEFRKNHILETLHEQGINISKFDAVCARGGLLRPIEGGTYVVNDEMIEDL KSGYAGQHASNLGGIIAREIADGLNIPSYIVDPVVVDEMSVLAKVSGMPEIERKSIFH ALNQKAVARKAAASLGKRYENMKMIITHMGGGITIGVHDRGRVVDVNNGLHGEGPFSP ERAGTVPAGDLVDLCFSGEYTKEEIMKKLVGTGGLLGYLGTNDAVKVEQMIQGGDEKA RFIYDAMAYQVAKEIGAASAALKGEVEAIVLTGGLAYGKSFVSAIRSYIDWISDVLVY PGENELQSLAQGALRVLQGEEQSKQYRIE*" gene complement(2367147..2368238) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" CDS complement(2368257..2369351) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" /EC_number="1.4.1.8" /EC_number="1.4.1.-" /EC_number="1.4.1.9" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid dehydrogenase" /protein_id="NP_390288.1" /db_xref="EnsemblGenomes-Gn:BSU24080" /db_xref="EnsemblGenomes-Tr:CAB14339" /db_xref="GOA:P54531" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR016211" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11723" /db_xref="UniProtKB/Swiss-Prot:P54531" /translation="MELFKYMEKYDYEQLVFCQDEQSGLKAIIAIHDTTLGPALGGTR MWTYENEEAAIEDALRLARGMTYKNAAAGLNLGGGKTVIIGDPRKDKNEEMFRAFGRY IQGLNGRYITAEDVGTTVEDMDIIHDETDYVTGISPAFGSSGNPSPVTAYGVYRGMKA AAKAAFGTDSLEGKTIAVQGVGNVAYNLCRHLHEEGANLIVTDINKQSVQRAVEDFGA RAVDPDDIYSQDCDIYAPCALGATINDDTIKQLKAKVIAGAANNQLKETRHGDQIHEM GIVYAPDYVINAGGVINVADELYGYNAERALKKVEGIYGNIERVLEISQRDGIPAYLA ADRLAEERIERMRRSRSQFLQNGHSVLSRR*" gene complement(2368257..2369351) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" CDS complement(2369363..2370262) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" /EC_number="2.3.1.19" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphate BCFA and butyryl coenzyme A transferase" /protein_id="NP_390289.2" /db_xref="EnsemblGenomes-Gn:BSU24090" /db_xref="EnsemblGenomes-Tr:CAB14340" /db_xref="GOA:P54530" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR012147" /db_xref="InterPro:IPR014079" /db_xref="SubtiList:BG11722" /db_xref="UniProtKB/Swiss-Prot:P54530" /translation="MKLKDLIGKASIHKNKTIAVAHAEDEEVIRAVKLAAEHLSARFL LTGDSKKLNELTSSMQGHQVEIVHANTPEESAKLAVRAVHHKTADVLMKGNVPTSVLL KAVLNRQEGLRSASVLSHVAVFDIPDFDRLMFVTDSAMNIAPSLEELRQILQNAVHVA HAVGNNMPKAAALAAVETVNPKMEATVNAAALAQMYKRGQIKGCIVDGPLALDNAVSQ IAAAQKKISGDVAGNADILLVPTIEAGNILYKSLIYFAKASVAAVITGAKAPIALTSR ADSAENKLYSIALAICASEEYTH*" gene complement(2369363..2370262) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" misc_feature complement(2370298..2370317) /Source="Nicolas_upshift_promotors" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2370303) /Source="Nicolas_upshifts" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" S_feature complement(2370305..2370386) /Source="Nicolas_S_feature" /locus_tag="new_2504707_2504788_c" /HighExp="Cold, LBGtran, G180, Lbexp, G135, G150, LBGexp, Diami, Oxctl, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S910" CDS complement(2370387..2372465) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_390290.1" /db_xref="EnsemblGenomes-Gn:BSU24100" /db_xref="EnsemblGenomes-Tr:CAB14341" /db_xref="GOA:P54529" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11721" /db_xref="UniProtKB/Swiss-Prot:P54529" /translation="MQKVLIVGAGKRGTALLHILIKTAIIDIIAVVDKDPEAPGLKEA EQYGIAVSSDWKPYIQQKPDIVIHTTGDQAVFDELLQRKHEDTIVMPGKMAYIVFQLM EEKQHLIQMLKEQTYKYDRIFNSTHDGMIFIDINEEIILFNHMAEKMVGKKREEVIGR PIKEVIPSTKMPRILKTRVPEYNQKQLLGDHLQIVTTRLPIIDEGGRLLGALCVFKDI TDAVELAEEVTNLKQVRTMLEAIIQSSDEAISVVDENGIGLLINKAYTKMTGLSEKEV IGKPANTDISEGESMHLKVLETRRPVRGVRMKVGPNEKEVIVNVAPVIVDGILKGSVG VIHDVSEIKMLTAELNRARQIIRTLEAKYTFDDIIGKSEQMLVALEQAKLGAKTPATI LLRGESGTGKELFAHAIHNESDRKYNKFIRVNCAALSENLLESELFGYEDGAFSGAKR GGKKGLFEEANNGSIFLDEIGELTQNMQAKLLRVLQEKEIVRVGGTKAIPVNVRVIAA TNVNIEKAMADGTFREDLYYRINRYPISIPPLRQRLEDIEALSVRLIQKINRDYGRNV KGLSQQALRALSAYHWPGNVRELENVLGRAMIFLNPHMEWIEKDHLPVFELEQKENDT DQGTGFDFPDIEGEKLSVAVEKFEAHLIQQTLEKHHFNRTKTAKALGVSIRNLYYKMD KYGLANEGMQ*" gene complement(2370387..2372465) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" promotor_-10 complement(2372525..2372544) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2372542) /Source="Nicolas_upshifts" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" promotor_-35 2372552..2372559 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2372561..2372564) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2372573..2372592 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2372580 /Source="Nicolas_upshifts" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" CDS 2372618..2372854 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390291.1" /db_xref="EnsemblGenomes-Gn:BSU24110" /db_xref="EnsemblGenomes-Tr:CAB14342" /db_xref="GOA:O32015" /db_xref="InterPro:IPR020138" /db_xref="SubtiList:BG13772" /db_xref="UniProtKB/Swiss-Prot:O32015" /translation="MSRLLALLILVIPGAISALGIKLMRDTLFGHTIKPFSALWLQGL SGFIFFAIGLYVLAGFILYRDRKRNQVSPRFRKR*" gene 2372618..2372854 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" downshifts 2372845 /Source="Nicolas_upshifts" /id="D1259" /incds=0 /nref=64 /ntot=230 /MaxReadThrough="2.80342" /MaxDrop="5.10794" /score="42.7247617" /energy="-11.9" /TU="NA" /idTUdmin="U1880" /TUdmin=0 /isTUend="TRUE" CDS complement(2372896..2373801) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" /EC_number="4.1.3.30" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12706720, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12706720, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylisocitrate lyase" /protein_id="NP_390292.1" /db_xref="EnsemblGenomes-Gn:BSU24120" /db_xref="EnsemblGenomes-Tr:CAB14343" /db_xref="GOA:P54528" /db_xref="InterPro:IPR012695" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018523" /db_xref="SubtiList:BG11720" /db_xref="UniProtKB/Swiss-Prot:P54528" /translation="MSWIVNKQSSQEELAGRFRKLMSAPDILQIPGAHDGMAALLAKE AGFSAIYLSGAAYTASRGLPDLGIITSAEIAERAKDLVRAADLPLLVDIDTGFGGVLN AARTAREMLEARVAAVQMEDQQLPKKCGHLNGKQLVPIKEMAQKIKAIKQAAPSLIVV ARTDARAQEGLDAAIKRSEAYIEAGADAIFPEALQAENEFRQFAERIPVPLLANMTEF GKTPYYRADEFEDMGFHMVIYPVTSLRAAAKACERMFGLMKEHGSQKEGLHDMQTRKE LYDTISYYDYEALDKTIAKTVLPDE*" gene complement(2372896..2373801) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" downshifts complement(2372899) /Source="Nicolas_upshifts" /id="D1260" /incds=0 /nref=29 /ntot=69 /MaxReadThrough="2.12559" /MaxDrop="5.62" /score="33.814061" /energy="-11.9" /TU="NA" /idTUdmin="U1884" /TUdmin=0 /isTUend="TRUE" CDS complement(2373819..2375237) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" /EC_number="4.2.1.79" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylcitrate dehydratase (promiscuous)" /protein_id="NP_390293.2" /db_xref="EnsemblGenomes-Gn:BSU24130" /db_xref="EnsemblGenomes-Tr:CAB14344" /db_xref="GOA:P45859" /db_xref="InterPro:IPR005656" /db_xref="InterPro:IPR012705" /db_xref="InterPro:IPR036148" /db_xref="SubtiList:BG11323" /db_xref="UniProtKB/Swiss-Prot:P45859" /translation="MPKTDRVIEEITDYVLEKEITSAEAYTTAGHVLLDTLGCGILAL RYPECTKLLGPIVPGTTVPNGSKVPGTSYVLDPVRAAFNIGCMIRWLDYNDTWLAAEW GHPSDNLGGILAAADYVSRVRLSEGKEPLTVRDVLEMMIKAHEIQGVLALENSLNRVG LDHVLFVKVATTAVAAKLLGGGREEIKNALSNAWIDNAALRTYRHSPNTGSRKSWAAG DATSRGVHLALMSLKGEMGYPTALSAPGWGFQDVLFNKKEIKLARPLDAYVMENVLFK VSYPAEFHAQTAAESAVILHPQVKNRIDEIDRVVIRTHESAIRIIDKKGPLHNPADRD HCLQYITAIGLLFGDITAQHYEAETANDPRIDKLRDKMEVTENKTYTEDYLKPDKRSI SNAVQVHFKDGTSTEMVECEFPLGHRFRREEAVPKLLEKFSDNLKTHFPDKQHKHIYE RCTSYETLQTMRVNEFVDMFCM*" gene complement(2373819..2375237) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" misc_feature complement(2374114..2374133) /Source="Nicolas_upshift_promotors" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2374131) /Source="Nicolas_upshifts" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2375252..2376370) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" /EC_number="2.3.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional citrate synthase/2-methylcitrate synthase" /protein_id="NP_390294.1" /db_xref="EnsemblGenomes-Gn:BSU24140" /db_xref="EnsemblGenomes-Tr:CAB14345" /db_xref="GOA:P45858" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG11322" /db_xref="UniProtKB/Swiss-Prot:P45858" /translation="MEEKQHYSPGLDGVIAAETHISYLDTQSSQILIRGYDLIELSET KSYLELVHLLLEGRLPEESEMETLERKINSASSLPADHLRLLELLPEDTHPMDGLRTG LSALAGYDRQIDDRSPSANKERAYQLLGKMPALTAASYRIINKKEPILPLQTLSYSAN FLYMMTGKLPSSLEEQIFDRSLVLYSEHEMPNSTFAARVIASTHSDLYGALTGAVASL KGNLHGGANEAVMYLLLEAKTTSDFEQLLQTKLKRKEKIMGFGHRVYMKKMDPRALMM KEALQQLCDKAGDHRLYEMCEAGERLMEKEKGLYPNLDYYAAPVYWMLGIPIPLYTPI FFSARTSGLCAHVIEQHANNRLFRPRVSYMGPRYQTKS*" gene complement(2375252..2376370) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" CDS complement(2376404..2377543) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="propionyl-CoA dehydrogenase subunit" /protein_id="NP_390295.2" /db_xref="EnsemblGenomes-Gn:BSU24150" /db_xref="EnsemblGenomes-Tr:CAB14346" /db_xref="GOA:P45857" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="PDB:5LNX" /db_xref="SubtiList:BG11321" /db_xref="UniProtKB/Swiss-Prot:P45857" /translation="MHVTQEQVMMRKMVRDFARKEIAPAAEIMEKTDEFPFQLIKKMG KHGLMGIPVPEQYGGAGADVVSYILAIHEISRISAAVGVILSVHTSVGTNPILYFGNE EQKMKYIPNLASGDHLGAFALTEPHSGSDAGSLRTTAIKKNGKYLLNGSKIFITNGGA ADIYITFALTAPDQGRHGISAFIVEKNTPGFTVGKKERKLGLYGSNTTELIFDNAEVP EANLLGKEGDGFHIAMANLNVGRIGIAAQALGIAEAALEHAVDYAKQRVQFGRPIAAN QGISFKLADMATRAEAARHLVYHAADLHNRGLNCGKEASMAKQFASDAAVKAALDAVQ IYGGYGYMKDYPVERLLRDAKVTQIYEGTNEIQRLIISKYLLGGT*" gene complement(2376404..2377543) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" CDS complement(2377571..2378434) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" /EC_number="1.1.1.157" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 18461320, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 18461320, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxybutyryl-CoA dehydrogenase" /protein_id="NP_390296.2" /db_xref="EnsemblGenomes-Gn:BSU24160" /db_xref="EnsemblGenomes-Tr:CAB14347" /db_xref="GOA:P45856" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR006180" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR022694" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11320" /db_xref="UniProtKB/Swiss-Prot:P45856" /translation="MEIKQIMVAGAGQMGSGIAQTAADAGFYVRMYDVNPEAAEAGLK RLKKQLARDAEKGKRTETEVKSVINRISISQTLEEAEHADIVIEAIAENMAAKTEMFK TLDRICPPHTILASNTSSLPITEIAAVTNRPQRVIGMHFMNPVPVMKLVEVIRGLATS EETALDVMALAEKMGKTAVEVNDFPGFVSNRVLLPMINEAIYCVYEGVAKPEAIDEVM KLGMNHPMGPLALADFIGLDTCLSIMEVLHSGLGDSKYRPCPLLRKYVKAGWLGKKSG RGFYDYEEKTS*" gene complement(2377571..2378434) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" CDS complement(2378459..2379640) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" /EC_number="2.3.1.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16352833, 18246303, 19016856, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352833, 18246303, 19016856, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="degradative acetoacetyl-CoA thiolase" /protein_id="NP_390297.1" /db_xref="EnsemblGenomes-Gn:BSU24170" /db_xref="EnsemblGenomes-Tr:CAB14348" /db_xref="GOA:P45855" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="PDB:5LP7" /db_xref="SubtiList:BG11319" /db_xref="UniProtKB/Swiss-Prot:P45855" /translation="MRKTVIVSAARTPFGKFGGVLKEVKAAELGGIVMKEALQQAGVS GDDVEGNVMGMVVQAGSGQIPSRQAARLAGMPWSVPSETLNKVCASGLRAVTLCDQMI RAQDADILVAGGMESMSNIPYAVPAGRWGARMGDGELRDLMVYDGLTCAFDEVHMAVH GNTAAKEYAISRREQDEWALRSHARAAKAADEGKFQDEIVPVNWIGRKGKPNVVDKDE AIRRDTSLDQLAKLAPIYASDGSITAGNAPGVNDGAGAFVLMSEEKAAELGKRPLATI LGFSTTGMPAHELAAAPGFAINKLLKKNGLTVQDIDLFEVNEAFASVVLTCEKIVGFD LEKVNVNGGAIALGHPIGASGARILMTLVYELKRRGGGLGVAAICSGAAQGDAVLVQV H*" gene complement(2378459..2379640) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" downshifts complement(2379220) /Source="Nicolas_upshifts" /id="D1261" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17207" /MaxDrop="2.33167" /score="-0.949614429" /energy="-7.8" /TU="U1884" /idTUdmin="U1885" /TUdmin=550 /isTUend="FALSE" misc_feature complement(2379327..2379333) /Source="Nicolas_upshift_promotors" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2379330) /Source="Nicolas_upshifts" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_no_box complement(2379554..2379654) /Source="Nicolas_upshift_promotors" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2379594) /Source="Nicolas_upshifts" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2379687..2379705) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2379705) /Source="Nicolas_upshifts" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" promotor_-35 complement(2379721..2379726) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2379767..2380498) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" /EC_number="3.1.4.46" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 14563871, 21966272, 22843846, 24373430, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 14563871, 21966272, 22843846, 24373430, 27780866; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycerophosphodiester phosphodiesterase (exolytic cleavage of individual teichoic acid monomer units)" /protein_id="NP_390298.2" /db_xref="EnsemblGenomes-Gn:BSU24180" /db_xref="EnsemblGenomes-Tr:CAB14349" /db_xref="GOA:P54527" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG11719" /db_xref="UniProtKB/Swiss-Prot:P54527" /translation="MTKIFAHRGASGQFPENTMLAFEKGIEAGADGIELDVQLTKDGR IVVIHDERLNRTTSLKGFVKDTAYDEVKTANAAAGHDQAYSDIKVPLLEDVLSWAVKK DFLINIELKNSVIRYEGMEEKVLEAVKRFNVEDRVILSTFNHDSLALCARLAPHIERA VLTSDVLYQADRYIASIPASGYHPKINSPGVTDEVLKKMRNGLIKVRPYTVNRPEDMK RLIEAGADGMFTDFPEKASALLKNE*" gene complement(2379767..2380498) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" downshifts complement(2379774) /Source="Nicolas_upshifts" /id="D1262" /incds=0 /nref=31 /ntot=180 /MaxReadThrough="0.31166" /MaxDrop="4.10202" /score="-0.949614429" /energy="-7.8" /TU="NA" /idTUdmin="U1885" /TUdmin="-4" /isTUend="TRUE" promotor_-10 complement(2380521..2380540) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2380532) /Source="Nicolas_upshifts" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" promotor_-35 complement(2380555..2380558) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2380577..2381197) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" /EC_number="3.5.1.28" /experiment="publication(s) with functional evidences, PMID:22843846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22843846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_390299.2" /db_xref="EnsemblGenomes-Gn:BSU24190" /db_xref="EnsemblGenomes-Tr:CAB14350" /db_xref="GOA:P54525" /db_xref="InterPro:IPR002508" /db_xref="SubtiList:BG11717" /db_xref="UniProtKB/Swiss-Prot:P54525" /translation="MRMLWRSLALCGLALTLAPCAQAAEPIEGKTVYIDAGHGGEDSG AVGNGLFEKDINLAVSEHVTDKLKEEGANPVASRSDDHFLTLEERVAKASANQADLFV SIHVNSGVASASGTETYFQSDYEGENSRRLASDIQSQLVSSLQTRDRGVKESDFYVIT YSQMPSVLAELGFITNSSDADKLGSEEYQQKAADAIVNGIDSYYDQ*" gene complement(2380577..2381197) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" CDS complement(2381212..2381505) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22843846; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390300.2" /db_xref="EnsemblGenomes-Gn:BSU24200" /db_xref="EnsemblGenomes-Tr:CAB14351" /db_xref="GOA:P40770" /db_xref="SubtiList:BG11030" /db_xref="UniProtKB/Swiss-Prot:P40770" /translation="MKQTVLLLFTALFLSGCSVASADDSVPRFTEEGKYIGSADPHTI AVSLNGEETMIQVPKDKRDECESLPDQTHVLVKYTKKDNGTLQLEDIQLRKNS*" gene complement(2381212..2381505) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" promotor_-10 complement(2381525..2381544) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2381531) /Source="Nicolas_upshifts" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" promotor_-35 complement(2381559..2381566) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2381761..2381768 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2381782..2381801 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2381799..2382004 /Source="Nicolas_S_feature" /locus_tag="new_2516201_2516406" /HighExp="Diami, dia15, dia5, H2O2, Paraq, LBGexp, G180, LBGstat, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99653599999999998" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S911" upshifts 2381799 /Source="Nicolas_upshifts" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" CDS 2381813..2381965 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513977.1" /translation="MKEVKAMKKFVLLLAAAVITCSIGHQISGGYKGPEKERPKHHSA LKIFSR*" gene 2381813..2381965 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" promotor_-35 2381973..2381980 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2381995..2382014 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2382006 /Source="Nicolas_upshifts" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" CDS 2382038..2383156 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-dependent flavin oxidoreductase" /protein_id="NP_390301.1" /db_xref="EnsemblGenomes-Gn:BSU24210" /db_xref="EnsemblGenomes-Tr:CAB14352" /db_xref="GOA:P54524" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG11716" /db_xref="UniProtKB/Swiss-Prot:P54524" /translation="MNPKYKPLFEPFTFKSGVTINNRIAVAPMTHYASNEDGTISEAE LDYIIPRSKEMGMVITACANVTPDGKAFPGQPAIHDDSNIPGLKKLAQAIQAQGAKAV VQIHHGGIECPSELVPQQDVVGPSDVFDNGKQIARALTEEEVENIVKAFGEATRRAIE AGFDGVEIHGANGYLIQQFYSPKTNQRTDRWGGSDEKRLAFPLAIVDEVKKAASEHAK GAFLVGYRLSPEEPETPGLTMTETYTLVDALGDKELDYLHISLMDVNSKARRGADPTR TRMDLLNERVGNKVPLIAVGSIHSADDALAVIENGIPLVAMGREILVDPNWTVKVKEG REKQIETVIKGTDKEKYHLPEPLWQAIVNTQGWVPYKD*" gene 2382038..2383156 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" downshifts 2383141 /Source="Nicolas_upshifts" /id="D1263" /incds=0 /nref=23 /ntot=181 /MaxReadThrough="1.88324" /MaxDrop="6.67511" /score="30.8551972" /energy="-16.1" /TU="NA" /idTUdmin="U1887" /TUdmin="-9" /isTUend="TRUE" S_feature complement(2383183..2383353) /Source="Nicolas_S_feature" /locus_tag="new_2517585_2517755_c" /HighExp="T0.30H, S6, S8, T1.30H, T1.0H, T-0.40H, S7, Salt, T0.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="1, 0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S912" downshifts complement(2383226) /Source="Nicolas_upshifts" /id="D1264" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="3.46085" /MaxDrop="2.69939" /score="-5.47428449" /energy="-16.1" /TU="U1889" /idTUdmin="U1890" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2383337..2383352) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2383353) /Source="Nicolas_upshifts" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" S_feature complement(2383355..2383483) /Source="Nicolas_S_feature" /locus_tag="new_2517757_2517885_c" /HighExp="S6, S8, S7, S5, BT, M9-stat, B36, G180, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S913" promotor_-35 complement(2383364..2383373) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2383482..2383501) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2383505) /Source="Nicolas_upshifts" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" promotor_-35 complement(2383515..2383523) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2383615) /Source="Nicolas_upshifts" /id="D1265" /incds=0 /nref=199 /ntot=267 /MaxReadThrough="2.54843" /MaxDrop="4.82417" /score="-1.10791055" /energy="-15.5" /TU="NA" /idTUdmin="U1891" /TUdmin=0 /isTUend="TRUE" CDS complement(2383621..2384424) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator, phosphorylated in response to complex YlbF/YmcA/YaaT" /protein_id="NP_390302.1" /db_xref="EnsemblGenomes-Gn:BSU24220" /db_xref="EnsemblGenomes-Tr:CAB14353" /db_xref="GOA:P06534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR012052" /db_xref="InterPro:IPR014879" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1LQ1" /db_xref="SubtiList:BG10765" /db_xref="UniProtKB/Swiss-Prot:P06534" /translation="MEKIKVCVADDNRELVSLLSEYIEGQEDMEVIGVAYNGQECLSL FKEKDPDVLVLDIIMPHLDGLAVLERLRESDLKKQPNVIMLTAFGQEDVTKKAVDLGA SYFILKPFDMENLVGHIRQVSGNASSVTHRAPSSQSSIIRSSQPEPKKKNLDASITSI IHEIGVPAHIKGYLYLREAISMVYNDIELLGSITKVLYPDIAKKFNTTASRVERAIRH AIEVAWSRGNIDSISSLFGYTVSMTKAKPTNSEFIAMVADKLRLEHKAS*" gene complement(2383621..2384424) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" promotor_-10 complement(2384467..2384485) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2384473) /Source="Nicolas_upshifts" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" S_feature complement(2384475..2384627) /Source="Nicolas_S_feature" /locus_tag="new_2518877_2519029_c" /HighExp="T1.30H, T3.0H, T2.30H, T2.0H, HiTm, Lbtran, T1.0H, T-0.40H, T0.30H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S914" promotor_-35 complement(2384496..2384504) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2384623..2384642) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2384635) /Source="Nicolas_upshifts" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" promotor_-35 complement(2384654..2384661) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2384700..2385980) /gene="spoIVB" /locus_tag="BSU_24230" /old_locus_tag="BSU24230" /EC_number="3.4.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12218026, 15292188, 16164552, 16238631, 16818230, 17493131, 17557826" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12218026, 15292188, 16164552, 16238631, 16818230, 17493131, 17557826; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="regulatory membrane-associated serine protease" /protein_id="NP_390303.2" /db_xref="EnsemblGenomes-Gn:BSU24230" /db_xref="EnsemblGenomes-Tr:CAB14354" /db_xref="GOA:P17896" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR008763" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR014219" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG10311" /db_xref="UniProtKB/Swiss-Prot:P17896" /translation="MPDNIRKAVGLILLVSLLSVGLCKPLKEYLLIPTQMRVFETQTQ AIETSLSVNAQTSESSEAFTVKKDPHEIKVTGKKSGESELVYDLAGFPIKKTKVHVLP DLKVIPGGQSIGVKLHSVGVLVVGFHQINTSEGKKSPGETAGIEAGDIIIEMNGQKIE KMNDVAPFIQKAGKTGESLDLLIKRDKQKIKTKLIPEKDEGEGKYRIGLYIRDSAAGI GTMTFYEPKTKKYGALGHVISDMDTKKPIVVENGEIVKSTVTSIEKGTGGNPGEKLAR FSSERKTIGDINRNSPFGIFGTLHQPIQNNISDQALPVAFSTEVKKGPAEILTVIDDD KVEKFDIEIVSTTPQKFPATKGMVLKITDPRLLKETGGIVQGMSGSPIIQNGKVIGAV THVFVNDPTSGYGVHIEWMLSEAGIDIYGKEKAS*" gene complement(2384700..2385980) /gene="spoIVB" /locus_tag="BSU_24230" /old_locus_tag="BSU24230" downshifts complement(2384715) /Source="Nicolas_upshifts" /id="D1266" /incds=0 /nref=34 /ntot=51 /MaxReadThrough="1.04939" /MaxDrop="7.80695" /score="49.1812184" /energy="-12.5" /TU="NA" /idTUdmin="U1893" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2386041..2386052) /Source="Nicolas_upshift_promotors" /id="U1893" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=830 /SigmaFactorBS="cattcgttcatcagtatatccaatgtttttcttcatatgaca GTTATAAataagccgtcagaaGGCAAAATTAAAtgatgtagcagcaagtcataaagaa g" /listShort="spoIVB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2386055) /Source="Nicolas_upshifts" /id="U1893" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=830 /SigmaFactorBS="cattcgttcatcagtatatccaatgtttttcttcatatgaca GTTATAAataagccgtcagaaGGCAAAATTAAAtgatgtagcagcaagtcataaagaa g" /listShort="spoIVB" /GFF_Attribute="listLong" promotor_-35 complement(2386067..2386073) /Source="Nicolas_upshift_promotors" /id="U1893" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=830 /SigmaFactorBS="cattcgttcatcagtatatccaatgtttttcttcatatgaca GTTATAAataagccgtcagaaGGCAAAATTAAAtgatgtagcagcaagtcataaagaa g" /listShort="spoIVB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2386155..2387885) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" /function="16.8: Protect" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor for double strand breaks DNA repair and genetic recombination" /protein_id="NP_390304.2" /db_xref="EnsemblGenomes-Gn:BSU24240" /db_xref="EnsemblGenomes-Tr:CAB14355" /db_xref="GOA:P17894" /db_xref="InterPro:IPR004604" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10310" /db_xref="UniProtKB/Swiss-Prot:P17894" /translation="MLAELSIKNFAIIEELTVSFERGLTVLTGETGAGKSIIIDAISL LVGGRGSSEFVRYGEAKAELEGLFLLESGHPVLGVCAEQGIDVSDEMIVMRRDISTSG KSVCRVNGKLVTIASLREIGRLLLDIHGQHDNQLLMEDENHLQLLDKFAGAEVESALK TYQEGYQRYVKLLKKLKQLSESEQEMAHRLDLIQFQLEEIESAKLELNEDEQLQEERQ QISNFEKIYESLQNAYNALRSEQGGLDWVGMASAQLEDISDINEPLKKMSESVSNSYY LLEDATFQMRNMLDELEFDPERLNYIETRLNEIKQLKRKYGATVEDILEYASKIEEEI DQIENRDSHLQSLKKELDSVGKDVAVEAANVSQIRKTWAKKLADEIHRELKSLYMEKS TFDTEFKVRTASRNEEAPLVNGQPVQLTEQGIDLVKFLISTNTGEPLKSLSKVASGGE LSRVMLAIKSIFSSQQDVTSIIFDEVDTGVSGRVAQAIAEKIHKVSIGSQVLCITHLP QVAAMADTHLYIAKELKDGRTTTRVKPLSKQEKVAEIGRMIAGVEVTDLTKRHAKELL KQADQVKTTG*" gene complement(2386155..2387885) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" downshifts complement(2386170) /Source="Nicolas_upshifts" /id="D1267" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="1.73202" /MaxDrop="6.33427" /score="20.028822" /energy="-12.4" /TU="NA" /idTUdmin="U1895" /TUdmin=0 /isTUend="TRUE" CDS complement(2387922..2388371) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AhrC(ArgR)-arginine)" /protein_id="NP_390305.1" /db_xref="EnsemblGenomes-Gn:BSU24250" /db_xref="EnsemblGenomes-Tr:CAB14356" /db_xref="GOA:P17893" /db_xref="InterPro:IPR001669" /db_xref="InterPro:IPR020899" /db_xref="InterPro:IPR020900" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR036251" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1F9N" /db_xref="PDB:2P5K" /db_xref="PDB:2P5L" /db_xref="PDB:2P5M" /db_xref="SubtiList:BG10309" /db_xref="UniProtKB/Swiss-Prot:P17893" /translation="MNKGQRHIKIREIITSNEIETQDELVDMLKQDGYKVTQATVSRD IKELHLVKVPTNNGSYKYSLPADQRFNPLSKLKRALMDAFVKIDSASHMIVLKTMPGN AQAIGALMDNLDWDEMMGTICGDDTILIICRTPEDTEGVKNRLLELL*" gene complement(2387922..2388371) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" S_feature complement(2388372..2388457) /Source="Nicolas_S_feature" /locus_tag="new_2522774_2522859_c" /HighExp="H2O2, G180, G135, G150, Oxctl, Heat, Paraq, C30, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S915" CDS complement(2388469..2389314) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" /EC_number="2.1.1.-" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2'-O-ribose RNA methyltransferase" /protein_id="NP_390306.2" /db_xref="EnsemblGenomes-Gn:BSU24260" /db_xref="EnsemblGenomes-Tr:CAB14357" /db_xref="GOA:P19672" /db_xref="InterPro:IPR002877" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR004538" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10308" /db_xref="UniProtKB/Swiss-Prot:P19672" /translation="MTSKKERLDVLLVERGLAETREKAKRAIMAGIVYSNENRLDKPG EKIDRDLPLTVKGNPLRYVSRGGLKLEKALKEFPVSVKDKIMIDIGSSTGGFTDCALQ NGAKQSYAVDVGYNQLAWKLRQDERVVVMERTNFRYATPADFTKGMPEFATIDVSFIS LRLILPVLRTLLVPGSDCMALVKPQFEAGRESVGKKGIVRDPKVHADVLKRMISFSAA EGYICKGLSFSPITGGDGNIEFLLHLHWPGEGQEGQELPEEEIMRVVEEAHKTLKEKK ADVPE*" gene complement(2388469..2389314) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" downshifts complement(2388502) /Source="Nicolas_upshifts" /id="D1268" /incds=0 /nref=1 /ntot=65 /MaxReadThrough="5.65358" /MaxDrop="2.6955" /score="4.97422627" /energy="-9.4" /TU="U1895,U1896,U1898" /idTUdmin="U1895" /TUdmin="-2332" /isTUend="FALSE" CDS complement(2389311..2391212) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" /EC_number="2.2.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12882400, 15292217, 17458547, 23840410, 25212876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-deoxyxylulose-5-phosphate synthase" /protein_id="NP_390307.1" /db_xref="EnsemblGenomes-Gn:BSU24270" /db_xref="EnsemblGenomes-Tr:CAB14358" /db_xref="GOA:P54523" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005477" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11715" /db_xref="UniProtKB/Swiss-Prot:P54523" /translation="MDLLSIQDPSFLKNMSIDELEKLSDEIRQFLITSLSASGGHIGP NLGVVELTVALHKEFNSPKDKFLWDVGHQSYVHKLLTGRGKEFATLRQYKGLCGFPKR SESEHDVWETGHSSTSLSGAMGMAAARDIKGTDEYIIPIIGDGALTGGMALEALNHIG DEKKDMIVILNDNEMSIAPNVGAIHSMLGRLRTAGKYQWVKDELEYLFKKIPAVGGKL AATAERVKDSLKYMLVSGMFFEELGFTYLGPVDGHSYHELIENLQYAKKTKGPVLLHV ITKKGKGYKPAETDTIGTWHGTGPYKINTGDFVKPKAAAPSWSGLVSGTVQRMAREDG RIVAITPAMPVGSKLEGFAKEFPDRMFDVGIAEQHAATMAAAMAMQGMKPFLAIYSTF LQRAYDQVVHDICRQNANVFIGIDRAGLVGADGETHQGVFDIAFMRHIPNMVLMMPKD ENEGQHMVHTALSYDEGPIAMRFPRGNGLGVKMDEQLKTIPIGTWEVLRPGNDAVILT FGTTIEMAIEAAEELQKEGLSVRVVNARFIKPIDEKMMKSILKEGLPILTIEEAVLEG GFGSSILEFAHDQGEYHTPIDRMGIPDRFIEHGSVTALLEEIGLTKQQVANRIRLLMP PKTHKGIGS*" gene complement(2389311..2391212) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" promotor_-35 2390420..2390426 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2390441..2390452 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2390449 /Source="Nicolas_upshifts" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2391213..2391341) /Source="Nicolas_S_feature" /locus_tag="new_2525615_2525743_c" /HighExp="Salt, Heat, dia15, H2O2, HiOs, Cold, T-5.40H, T3.30H, SMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S916" promotor_-10 complement(2391336..2391355) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2391341) /Source="Nicolas_upshifts" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" promotor_-35 complement(2391370..2391376) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2391387..2392277) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" /EC_number="2.5.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755734, 12682299, 17147392, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate synthase" /protein_id="NP_390308.2" /db_xref="EnsemblGenomes-Gn:BSU24280" /db_xref="EnsemblGenomes-Tr:CAB14359" /db_xref="GOA:P54383" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG11714" /db_xref="UniProtKB/Swiss-Prot:P54383" /translation="MTNKLTSFLADRKKTIENQLSVYTEKLDMPDSLKKSMLYSLQAG GKRLRPLIVLAVLNAYGKSEKDGIPVGCAVEMIHTYSLIHDDLPCMDDDDLRRGKPTN HKVFGEATAVLAGDGLLTESFKLITSHVSDEVSAEKRLRLVNELISAAGTEGMVGGQV ADMEAENRQVTLEELESIHERKTAKLLGFCVIAGAILADAPEEDIETLRTFSSHIGIG FQIRDDILDLEGSEEKIGKRVGSDTTNDKSTYPSLLSLEGAKHKLDVHIKEAKRLIGG LSLQKDLLYELCDLIAARDH*" gene complement(2391387..2392277) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" CDS complement(2392267..2392521) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" /EC_number="3.1.11.6" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11381137, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (small subunit)" /protein_id="NP_390309.2" /db_xref="EnsemblGenomes-Gn:BSU24290" /db_xref="EnsemblGenomes-Tr:CAB14360" /db_xref="GOA:P54522" /db_xref="InterPro:IPR003761" /db_xref="InterPro:IPR037004" /db_xref="SubtiList:BG11713" /db_xref="UniProtKB/Swiss-Prot:P54522" /translation="MTDVKKNENMTFEEAMKGLESIVSKLEEGDVPLEQAINYFQEGM ALSKMCHEKLQKVEKQMDFILKEDGELAPFSVQEEDEGDK*" gene complement(2392267..2392521) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" CDS complement(2392518..2393864) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" /EC_number="3.1.11.6" /function="16.9: Replicate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17182742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (large subunit)" /protein_id="NP_390310.2" /db_xref="EnsemblGenomes-Gn:BSU24300" /db_xref="EnsemblGenomes-Tr:CAB14361" /db_xref="GOA:P54521" /db_xref="InterPro:IPR003753" /db_xref="InterPro:IPR020579" /db_xref="InterPro:IPR025824" /db_xref="SubtiList:BG11712" /db_xref="UniProtKB/Swiss-Prot:P54521" /translation="MGEAAYVTVSALTKYIKRKFDVDPHLENIWIKGELSNVKIHTRG HIYFTLKDENARMQSVMFARQSERLPFKPENGMKVLVRGGISVYEPSGNYQLYAKEMQ PDGVGALYLAYEELKKKLAGEGLFDDRYKKQIPAFPATIGVVTSPTGAAVRDVITTLK RRYPLVKVIVLPALVQGENASRSIVTRIEEANEKEICDVLIVGRGGGSIEELWAFNEE IVARAIFASNIPIISAVGHETDFTISDFVADIRAATPTGAAEIAVPHTTDLIERTKTA EVRMTRAMQQHLGQKKERIQTLQSSYAFRFPKRLYAQKEQQFDLAYQQFQAQLTALLD RKSRQLERETYRLEALHPHEQLKQARTRYQEQTNQLRKNMNIQMKQLHSQFQTVLGKL NALSPLQVMERGYSLAYKEDKLIKSVSQIEEQDRLEIKLKDGVLTCEVLEKRGEEK*" gene complement(2392518..2393864) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" S_feature complement(2393865..2394001) /Source="Nicolas_S_feature" /locus_tag="new_2528267_2528403_c" /HighExp="H2O2, G180, G135, Cold, G150, Paraq, Oxctl, LBGstat, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S917" CDS complement(2394002..2394853) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" /EC_number="1.5.1.5" /EC_number="3.5.4.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7061514, 9454603, 12682299, 19171795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylenetetrahydrofolate dehydrogenase; methenyltetrahydrofolate cyclohydrolase" /protein_id="NP_390311.1" /db_xref="EnsemblGenomes-Gn:BSU24310" /db_xref="EnsemblGenomes-Tr:CAB14362" /db_xref="GOA:P54382" /db_xref="InterPro:IPR000672" /db_xref="InterPro:IPR020630" /db_xref="InterPro:IPR020631" /db_xref="InterPro:IPR020867" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11711" /db_xref="UniProtKB/Swiss-Prot:P54382" /translation="MTATIIDGKETAREKREQLAKEVEELKKQGVTPGLAVILIGDDP ASHSYVRGKKKAAETMGMNFKLDQFDSSLTEAELLSIIDQYNQDPEFHGILVQLPLPD HISEKAVIERISPDKDVDGFHPLNVGKMLLGEDTFLPCTPHGIVELLKKTNIDLSGKE VVVVGRSNIVGKPVGQLLLNENATVTYCHSRTENITEHTKKADILVVAVGRANFISAD QIKEGAVVIDVGVNRLENGKLCGDVEFEGAKEKASFITPVPGGVGPMTITMLAHNTVK SAKRTLS*" gene complement(2394002..2394853) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" CDS complement(2394865..2395260) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16707701, 16946247, 27964882; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription termination factor NusB" /protein_id="NP_390312.2" /db_xref="EnsemblGenomes-Gn:BSU24320" /db_xref="EnsemblGenomes-Tr:CAB14363" /db_xref="GOA:P54520" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR011605" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG11710" /db_xref="UniProtKB/Swiss-Prot:P54520" /translation="MKRRTAREKALQALFQIDVSDIAVNEAIEHALDEEKTDPFFEQL VHGVLEHQDQLDEMISKHLVNWKLDRIANVDRAILRLAAYEMAYAEDIPVNVSMNEAI ELAKRFGDDKATKFVNGVLSNIKSDIEQS*" gene complement(2394865..2395260) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" misc_feature complement(2395303..2395322) /Source="Nicolas_upshift_promotors" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2395322) /Source="Nicolas_upshifts" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" S_feature complement(2395324..2395486) /Source="Nicolas_S_feature" /locus_tag="new_2529726_2529888_c" /HighExp="G180, G150, Oxctl, Etha, G135, GM 120, dia0, HPh, MG 150, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S918" CDS complement(2395524..2395931) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 17114254, 22720735, 28579978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 17114254, 22720735, 28579978; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="alkaline shock protein" /protein_id="NP_390313.2" /db_xref="EnsemblGenomes-Gn:BSU24330" /db_xref="EnsemblGenomes-Tr:CAB14364" /db_xref="InterPro:IPR005531" /db_xref="SubtiList:BG11709" /db_xref="UniProtKB/Swiss-Prot:P54519" /translation="MKDNSLLKMDHEDTHLGKVEIAPEVIEVIAGIAASEVDGVAEMR GNFATGVVERFGKVNHGKGVKVDLADDGITIDVYCVVTFGVSIPKVAASVQENIRQTL LNMTSLSINEINIHIVGIQFDTKAQEVQIDEEM*" gene complement(2395524..2395931) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" downshifts complement(2395531) /Source="Nicolas_upshifts" /id="D1269" /incds=0 /nref=6 /ntot=76 /MaxReadThrough="6.4099" /MaxDrop="4.1473" /score="9.44795832" /energy="-9.5" /TU="U1897,U1898" /idTUdmin="U1899" /TUdmin=2409 /isTUend="FALSE" CDS complement(2395952..2397304) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" /EC_number="6.3.4.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxylase subunit)" /protein_id="NP_390314.2" /db_xref="EnsemblGenomes-Gn:BSU24340" /db_xref="EnsemblGenomes-Tr:CAB14365" /db_xref="GOA:P49787" /db_xref="InterPro:IPR004549" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11384" /db_xref="UniProtKB/Swiss-Prot:P49787" /translation="MIKKLLIANRGEIAVRIIRACRELGIETVAVYSEADKDALHVQM ADEAFCIGPKASKDSYLNVTNIVSVAKLTGTDAIHPGYGFLAENADFAELCEEVNVTF VGPSADAISKMGTKDVARETMKQAGVPIVPGSQGIIENVEEAVSLANEIGYPVIIKAT AGGGGKGIRVARTEEELINGIKITQQEAATAFGNPGVYIEKYIEDFRHVEIQVLADNY GNTIHLGERDCSIQRRLQKLLEESPSPALDSEIREQMGDAAVKAAKAVGYTGAGTVEF IYDYNEQRYYFMEMNTRIQVEHPVTEMVTGTDLIKEQIKVASGMELSLKQEDVEFEGW AIECRINAENPSKNFMPSPGEIKMYLPPGGLGVRVDSAAYPGYSIPPYYDSMIAKVIT YGKTRDEAIARMKRALSEFVIEGIETTIPFHLKLLEHETFVSGEFNTKFLETYDVMGS *" gene complement(2395952..2397304) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" promotor_-10 complement(2396833..2396852) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-10" upshifts complement(2396840) /Source="Nicolas_upshifts" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" promotor_-35 complement(2396867..2396873) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-35" CDS complement(2397316..2397795) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796, 15518551" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796, 15518551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxyl carrier subunit)" /protein_id="NP_390315.1" /db_xref="EnsemblGenomes-Gn:BSU24350" /db_xref="EnsemblGenomes-Tr:CAB14366" /db_xref="GOA:P49786" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001249" /db_xref="InterPro:IPR001882" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG11383" /db_xref="UniProtKB/Swiss-Prot:P49786" /translation="MLNIKEIHELIKAIDESTIDEFVYENEGVSLKLKKHEAGTVQVM QQAPAAPVQAQAPQAVQPQAQQAAAPAQEAPKQDENLHKITSPMVGTFYASSSPEAGP YVTAGSKVNENTVVCIVEAMKLFNEIEAEVKGEIVEVLVENGQLVEYGQPLFLVKAE* " gene complement(2397316..2397795) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" promotor_-10 complement(2397854..2397873) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2397865) /Source="Nicolas_upshifts" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" promotor_-35 complement(2397887..2397894) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2397951..2398607) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15028710, 15752199, 16959571, 1766372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15028710, 15752199, 16959571, 1766372; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation ratchet engulfment protein" /protein_id="NP_390316.2" /db_xref="EnsemblGenomes-Gn:BSU24360" /db_xref="EnsemblGenomes-Tr:CAB14367" /db_xref="GOA:P49785" /db_xref="InterPro:IPR024232" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11415" /db_xref="UniProtKB/Swiss-Prot:P49785" /translation="MLKKQTVWLLTMLSLVVVLSVYYIMSPESKNAVQMQSEKSASDS GEVATEKAPAKQDTKEKSGTETEKGKEDGTKGTKDSSADKETSAEASEKGTVVTETAD DDLFTTYRLDLEDARSKEREELNAIVSSDDATAKEKSEAYDKMTALSEVEGTEKQLET LIKTQGYEDALVNAEGDKINITVKSDKHSKSKATAIIDLVAKEIKTMKDVAVTFEPSK *" gene complement(2397951..2398607) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" downshifts complement(2397958) /Source="Nicolas_upshifts" /id="D1270" /incds=0 /nref=26 /ntot=57 /MaxReadThrough="0.0903599999999987" /MaxDrop="6.40434" /score="21.0450747" /energy="-13" /TU="NA" /idTUdmin="U1899" /TUdmin="-18" /isTUend="TRUE" CDS complement(2398608..2399297) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation engulfment assembly protein" /protein_id="NP_390317.2" /db_xref="EnsemblGenomes-Gn:BSU24370" /db_xref="EnsemblGenomes-Tr:CAB14368" /db_xref="GOA:P49784" /db_xref="InterPro:IPR014195" /db_xref="SubtiList:BG11414" /db_xref="UniProtKB/Swiss-Prot:P49784" /translation="MNKNGLWNVLKKQFLPGQTKDGEKPKLTKYHYFLFVFVLGVSFM LVSQLFSSPEKTENAKTITAVSSQHSADSKEKTAEVFKASKSDKPKDSIDDYEKEYEN QLKEILETIIGVDDVSVVVNVDATSLKVYEKNKSNKNTTTEETDKEGGKRSVTDQSSE EEIVMIKNGDKETPVVVQTKKPDIRGVLVVAQGVDNVQIKQTIIEAVTRVLDVPSHRV AVAPKKIKEDS*" gene complement(2398608..2399297) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" CDS complement(2399290..2399910) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390318.1" /db_xref="EnsemblGenomes-Gn:BSU24380" /db_xref="EnsemblGenomes-Tr:CAB14369" /db_xref="GOA:P49783" /db_xref="InterPro:IPR014245" /db_xref="SubtiList:BG11413" /db_xref="UniProtKB/Swiss-Prot:P49783" /translation="MSFLTEWLTTIVLFILFAIVIDMLLPSSSMQKYAKMVVSLLLIV VMLTPIFKLFKTDPEVIFEYLTKNGQSESADIKNQINSKKIEIQASQRAYILEEMAVQ LKKKAEERFSHDEYKVGRIKLTAGEKVDSEEDIKTISVYMAPSSEKTVQTVAPVHIDT DHAYVTKEAAEQKEAKQIQTQLADIWEIGSEKITVHMEGGESVGNE*" gene complement(2399290..2399910) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" promotor_-10 complement(2399616..2399634) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2399634) /Source="Nicolas_upshifts" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" promotor_-35 complement(2399650..2399655) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2399924..2401123) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390319.2" /db_xref="EnsemblGenomes-Gn:BSU24390" /db_xref="EnsemblGenomes-Tr:CAB14370" /db_xref="GOA:P49782" /db_xref="InterPro:IPR014194" /db_xref="SubtiList:BG11412" /db_xref="UniProtKB/Swiss-Prot:P49782" /translation="MKRFQWVLLLAVLIIAGRAEIVQAAGNAEQTEDHAETAEQLAER TAASLETDKIGEFWNDIMTEYGGLLPESQKGSLMEFINGDKSFSPQEWLKALFSYLFH EVLANGKLLGTLILLTIFCVILQLLQNAFQQSTVSKVAYSIVYMVLIILALNSFHVAI NYATEAIQTMTSFILALIPLLLALLASSGGAVSAAFFHPVILFLMNTSGLLIQNIVMP LIFLSAILSIVSTMTEQYKVTQLANLLRNIAIGALAVFLTIFLGVISVQGASAAVTDG ITLRTAKFITGNFIPVLGRMFTDATDTVISASLLLKNTVGILGVAILICIAAFPAIKV LSLAFIYKLAAAILQPLGGGPVITCLDVISKSVIYIFAALAIVSLMFFLSLTVIITAG NLTMMMK*" gene complement(2399924..2401123) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" CDS complement(2401142..2401543) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390320.1" /db_xref="EnsemblGenomes-Gn:BSU24400" /db_xref="EnsemblGenomes-Tr:CAB14371" /db_xref="GOA:P49781" /db_xref="InterPro:IPR014211" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11411" /db_xref="UniProtKB/Swiss-Prot:P49781" /translation="MQIDIVQIVGLGLIATFLSLIVKEQKPTFAFLIVVFAGCAIFLY LVDQIYDIIRMIEKIAINANVNMVYVETILKIIGIAYIAEFGAQLTKDAGQGAIASKI ELAGKILILVMAVPILTVIIETILGLIPSMS*" gene complement(2401142..2401543) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" CDS complement(2401550..2401756) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390321.1" /db_xref="EnsemblGenomes-Gn:BSU24410" /db_xref="EnsemblGenomes-Tr:CAB14372" /db_xref="GOA:P49780" /db_xref="InterPro:IPR009570" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11410" /db_xref="UniProtKB/Swiss-Prot:P49780" /translation="MGVDVNVIFQIAGVGIVVAFLHTILDQMGKKEYAQWVTLLGFIY ILFMVATIVDDLFKKIKAVFLFQG*" gene complement(2401550..2401756) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" CDS complement(2401779..2402294) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390322.1" /db_xref="EnsemblGenomes-Gn:BSU24420" /db_xref="EnsemblGenomes-Tr:CAB14373" /db_xref="GOA:Q01368" /db_xref="InterPro:IPR014198" /db_xref="SubtiList:BG10541" /db_xref="UniProtKB/Swiss-Prot:Q01368" /translation="MLKLLGAVFIVVATTWTGFEMAKIYTERPRQIRQLRAALQSLEA EIMYGHTPLHTASQQIAKQLAQPVSTLFSAFSDQLDKGSDSAKTAWEQSLKKVWDTLS LKKSEYEVLKQFGETLGIHDRISQQKHIKLALTHLEASEADAEQAQAKNEKMIKSLGF LAGLLLILLLM*" gene complement(2401779..2402294) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" CDS complement(2402288..2403211) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATP-binding stage III sporulation protein" /protein_id="NP_390323.1" /db_xref="EnsemblGenomes-Gn:BSU24430" /db_xref="EnsemblGenomes-Tr:CAB14374" /db_xref="GOA:Q01367" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR014217" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10540" /db_xref="UniProtKB/Swiss-Prot:Q01367" /translation="MNEIAEVLPESMKNALSEIPEQQWLEIEEVRIRINRPVELIRRG QPVYLSYAGTAEDAHLILSRLSNYSMYTLEEELKKGYVTIRGGHRVGLAGRVITENGG VKGLRDIASFNIRIARQKLGIAEPLLPYLYQNSWLNTLIIGPPQTGKTTLLRDLARLS STGKKNMLPVKTGIVDERSEIAGCLRGIPQHQFGQRIDVLDACPKAEGLMMMIRSMSP EVMIVDEIGRMEDTDALLEALHAGVSVIVSAHGWSISDLMKRPSLKRLWEERAFDRYL ELSRAKGPGTVSQIYDKDGNVLSRTTGVKTC*" gene complement(2402288..2403211) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" S_feature complement(2403212..2403286) /Source="Nicolas_S_feature" /locus_tag="new_2537614_2537688_c" /HighExp="S3, LoTm, S4, T5.0H, M9-stat, S5, BT, S7, S6, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S919" CDS complement(2403287..2403568) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390324.1" /db_xref="EnsemblGenomes-Gn:BSU24440" /db_xref="EnsemblGenomes-Tr:CAB14375" /db_xref="GOA:P49779" /db_xref="InterPro:IPR020390" /db_xref="SubtiList:BG11459" /db_xref="UniProtKB/Swiss-Prot:P49779" /translation="MKFLLGNINSTVLTMAGLRVLSSMIELTAAIVMLVTNDVRKAVV VNSILAIVGPLIFIITMTVGIYQIAGQLSYAKLILIFTGVVLILAGVHK*" gene complement(2403287..2403568) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" promotor_-10 complement(2403588..2403606) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-10" upshifts complement(2403611) /Source="Nicolas_upshifts" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" promotor_-35 complement(2403622..2403627) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-35" CDS complement(2403713..2404270) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor P" /protein_id="NP_390325.2" /db_xref="EnsemblGenomes-Gn:BSU24450" /db_xref="EnsemblGenomes-Tr:CAB14376" /db_xref="GOA:P49778" /db_xref="InterPro:IPR001059" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR011768" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013185" /db_xref="InterPro:IPR013852" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015365" /db_xref="InterPro:IPR020599" /db_xref="SubtiList:BG11460" /db_xref="UniProtKB/Swiss-Prot:P49778" /translation="MISVNDFRTGLTIEVDGGIWRVVDFQHVKPGKGAAFVRSKLRNL RTGAIQEKTFRAGEKVAKAQIETKTMQYLYANGDQHVFMDTSSYEQLELSATQIEEEL KYLLENMSVHIMMYQDETLGIELPNTVELKVVETEPGIKGDTASGGTKPAKTETGLVV NVPFFVNEGDTLVVNTSDGSYVSRA*" gene complement(2403713..2404270) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" downshifts complement(2403725) /Source="Nicolas_upshifts" /id="D1271" /incds=0 /nref=256 /ntot=266 /MaxReadThrough="0.83852" /MaxDrop="7.73118" /score="27.4193827" /energy="-13.5" /TU="NA" /idTUdmin="U1901" /TUdmin=0 /isTUend="TRUE" CDS complement(2404295..2405356) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" /EC_number="3.4.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:23144141, 26735940, 27002156" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23144141, 26735940, 27002156; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase (Met-Xaa and Xaa-Pro, Xaa-Pro-Xaa)" /protein_id="NP_390326.1" /db_xref="EnsemblGenomes-Gn:BSU24460" /db_xref="EnsemblGenomes-Tr:CAB14377" /db_xref="GOA:P54518" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG11708" /db_xref="UniProtKB/Swiss-Prot:P54518" /translation="MKLEKLRNLFGQLGIDGMLITSNTNVRYMTGFTGSAGLAVISGD KAAFITDFRYTEQAKVQVKGFEIIEHGGSLIQTTADTVESFGIKRLGFEQNSMTYGTY ASYSAVISDAELVPVAESVEKLRLIKSSEEIKILEEAAKIADDAFRHILTFMKPGISE IAVANELEFYMRSQGADSSSFDMIVASGLRSSLPHGVASDKLIESGDLVTLDFGAYYK GYCSDITRTVAVGQPSDQLKEIYQVVFDAQALGVAHIKPGMTGKEADALTRDHIAAKG YGDYFGHSTGHGLGMEVHESPGLSVRSSAILEPGMVVTVEPGIYIPETGGVRIEDDIV ITENGNRTITHSPKELIIL*" gene complement(2404295..2405356) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" CDS complement(2405353..2405799) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10870960, 19099550; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase, type II" /protein_id="NP_390327.1" /db_xref="EnsemblGenomes-Gn:BSU24470" /db_xref="EnsemblGenomes-Tr:CAB14378" /db_xref="GOA:P54517" /db_xref="InterPro:IPR001874" /db_xref="InterPro:IPR018509" /db_xref="InterPro:IPR036441" /db_xref="PDB:1GQO" /db_xref="SubtiList:BG11707" /db_xref="UniProtKB/Swiss-Prot:P54517" /translation="MPHFLILNGPNVNRLGSREPEVFGRQTLTDIETDLFQFAEALHI QLTFFQSNHEGDLIDAIHEAEEQYSGIVLNPGALSHYSYAIRDAVSSISLPVVEVHLS NLYAREEFRHQSVIAPVAKGQIVGLGAEGYKLAVRYLLSQQGGESR*" gene complement(2405353..2405799) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" promotor_-10 complement(2405848..2405867) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2405864) /Source="Nicolas_upshifts" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" promotor_-35 complement(2405880..2405887) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2405886..2406422) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390328.1" /db_xref="EnsemblGenomes-Gn:BSU24480" /db_xref="EnsemblGenomes-Tr:CAB14379" /db_xref="GOA:P54516" /db_xref="InterPro:IPR024563" /db_xref="SubtiList:BG11706" /db_xref="UniProtKB/Swiss-Prot:P54516" /translation="MMTSEKDTEQNEELNEKQKPPVSMAGRVAATGFCGGVLWSFVAY IAYLFHFSEISPNMILQPFVLGEWKKHGLGTVISIILIGVISIGAAFLYFLLLKRLKT MWPGILYGLVLWLLVFFVFNPIFPDVRTVTELTSDTIITTICIYLLYGLFVGYSISFE YNELNSEKLARALGMHRE*" gene complement(2405886..2406422) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" promotor_-10 complement(2406435..2406446) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-10" upshifts complement(2406444) /Source="Nicolas_upshifts" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" promotor_-35 complement(2406460..2406466) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-35" promotor_-35 2406492..2406498 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2406511 /Source="Nicolas_upshifts" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" promotor_-10 2406513..2406531 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2406568..2406571 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2406586..2406605 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2406597 /Source="Nicolas_upshifts" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" CDS 2406649..2407605 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390329.2" /db_xref="EnsemblGenomes-Gn:BSU24490" /db_xref="EnsemblGenomes-Tr:CAB14380" /db_xref="GOA:P54515" /db_xref="InterPro:IPR010787" /db_xref="SubtiList:BG11705" /db_xref="UniProtKB/Swiss-Prot:P54515" /translation="MSKHKVPPAYGGQAVVEGVMFGGKHHYVTAIRRTDGSIDFFKLP RKHNPKLNIVKKIPFLRGIAAIIEASANGTKHLNFSSERYGLDPSEDETLEQEEKKSS GLSMYLSLAVIGVLSFLFSKFVFTLVPVFLAELTRPIFSLNTAQIAIESLFKLILLLG YIYFLSMTPLIKRVFQYHGAEHKVINCYEQNLPITVENVQNQSRLHYRCGSSFILFTI IVGMFVYLLVPTDPLWLRVIDRVALIPVVLGISFEVLQLTNKVRDIPGLKLLGYPGLW LQLLTTKEPKDEQVEVAIESFNELLRLEALSEQNQKPSHNVI*" gene 2406649..2407605 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" CDS 2407645..2408040 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390330.1" /db_xref="EnsemblGenomes-Gn:BSU24500" /db_xref="EnsemblGenomes-Tr:CAB14381" /db_xref="GOA:P54514" /db_xref="SubtiList:BG11704" /db_xref="UniProtKB/Swiss-Prot:P54514" /translation="MNHRVQPIIAVLIALGAFGFLYVLVTNPGEMAKMAVTVIVAGII IYFIVKYVMNRNAGSEGAAFKKAAKQSRRRMKEQKAKHRAGHKGRVSHLRSVPSASKP KPMILKKKSQTQLTVIEGKKNKKKNRALF*" gene 2407645..2408040 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" promotor_no_box 2407923..2408023 /Source="Nicolas_upshift_promotors" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2407983 /Source="Nicolas_upshifts" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2408026 /Source="Nicolas_upshifts" /id="D1272" /incds=0 /nref=116 /ntot=283 /MaxReadThrough="2.23161" /MaxDrop="5.94415" /score="29.0609078" /energy="-8" /TU="NA" /idTUdmin="U1903" /TUdmin="-1" /isTUend="TRUE" CDS complement(2408037..2408912) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipase / acyl esterase" /protein_id="NP_390331.1" /db_xref="EnsemblGenomes-Gn:BSU24510" /db_xref="EnsemblGenomes-Tr:CAB14382" /db_xref="GOA:P54513" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG11703" /db_xref="UniProtKB/Swiss-Prot:P54513" /translation="MYIDGVFSGGGVKGIALAGAYEVLEEKGFRFKRVAGTSAGAIIA AFIASGYTSKEIHALIEEVDGEKLLDQRYSFLPLKMLQWVSIYWRLGLYKGDTIEKWI ADLLRAKGIRVFGDLQKGSLRLIASDLTNGTMIVLPDDLARYGLNPDMFPVARAVRMS CSIPYFFEPIKLKTDTGTATVVDGGVLSNFPIWLFSKERKRPVIGVTLAPRERERPKK NIRNAFELFGALFETMKDAHDARHIASRYEQNIIFLPVDDVMATDFHLTQQKKLALIE LGKRRTELFLKQWTY*" gene complement(2408037..2408912) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" promotor_-10 complement(2408939..2408957) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2408956) /Source="Nicolas_upshifts" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" promotor_-35 complement(2408973..2408978) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2409038..2409466) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (hydrogen peroxide sensing, allosterically regulated by Mn2+)" /protein_id="NP_390332.2" /db_xref="EnsemblGenomes-Gn:BSU24520" /db_xref="EnsemblGenomes-Tr:CAB14383" /db_xref="GOA:P54512" /db_xref="InterPro:IPR001367" /db_xref="InterPro:IPR022687" /db_xref="InterPro:IPR022689" /db_xref="InterPro:IPR022897" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036421" /db_xref="PDB:1ON1" /db_xref="PDB:1ON2" /db_xref="PDB:2EV0" /db_xref="PDB:2EV5" /db_xref="PDB:2EV6" /db_xref="PDB:2F5C" /db_xref="PDB:2F5D" /db_xref="PDB:2F5E" /db_xref="PDB:2F5F" /db_xref="PDB:2HYF" /db_xref="PDB:2HYG" /db_xref="PDB:3R60" /db_xref="PDB:3R61" /db_xref="PDB:4HV5" /db_xref="PDB:4HV6" /db_xref="PDB:4HX4" /db_xref="PDB:4HX7" /db_xref="PDB:4HX8" /db_xref="SubtiList:BG11702" /db_xref="UniProtKB/Swiss-Prot:P54512" /translation="MTTPSMEDYIEQIYMLIEEKGYARVSDIAEALAVHPSSVTKMVQ KLDKDEYLIYEKYRGLVLTSKGKKIGKRLVYRHELLEQFLRIIGVDEEKIYNDVEGIE HHLSWNSIDRIGDLVQYFEEDDARKKDLKSIQKKTEHHNQ*" gene complement(2409038..2409466) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" downshifts complement(2409065) /Source="Nicolas_upshifts" /id="D1273" /incds=0 /nref=322 /ntot=333 /MaxReadThrough="2.568" /MaxDrop="7.28707" /score="15.888362" /energy="-12" /TU="NA" /idTUdmin="U1908" /TUdmin=6 /isTUend="TRUE" promotor_-10 complement(2409501..2409520) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2409509) /Source="Nicolas_upshifts" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" promotor_-35 complement(2409536..2409540) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2409566..2410402) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" /EC_number="2.3.1.181" /function="3: Fatty acid and phospholipid metabolism" /experiment="publication(s) with functional evidences, PMID:20882995, 21338420, 21338421, 23960015" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20882995, 21338420, 21338421, 23960015; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein octanoyltransferase" /protein_id="NP_390333.1" /db_xref="EnsemblGenomes-Gn:BSU24530" /db_xref="EnsemblGenomes-Tr:CAB14384" /db_xref="GOA:P54511" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024898" /db_xref="SubtiList:BG11701" /db_xref="UniProtKB/Swiss-Prot:P54511" /translation="MQKETWRFIDSGNASPAFNMALDEALLYWHSEKKIPPVIRFYGW NPATLSVGYFQNIKKEINFEAVHKYNLGFVRRPTGGRGVLHDQELTYSVIVSEEHPEM PATVTEAYRVISEGILQGFRNLGLDAYFAIPRTEKEKESLKNPRSSVCFDAPSWYELV VEGRKVAGSAQTRQKGVILQHGSILLDLDEDKLFDLFLYPSERVRERMQRNFKNKAVA INELIEKRVTMDEARKAFKEGFETGLNIHLEPYELSQEELDFVHHLAETKYASDEWNY KR*" gene complement(2409566..2410402) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" promotor_-10 complement(2410426..2410445) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2410437) /Source="Nicolas_upshifts" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" S_feature complement(2410439..2410983) /Source="Nicolas_S_feature" /locus_tag="new_2544841_2545385_c" /HighExp="Lbstat, LPhT, HiOs, M0t90, S1, M40t90, Sw, S0, B36, BC" /AntisenseName="yqhL" /AntisenseCor="-0.136624541005539" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S920" promotor_-35 complement(2410459..2410466) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2410483..2410488 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2410502..2410521 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2410502 /Source="Nicolas_upshifts" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" S_feature 2410513..2410592 /Source="Nicolas_S_feature" /locus_tag="new_2544915_2544994" /HighExp="dia15, H2O2, dia5, Diami, MG-0.2, G180, UNK1, LBGexp, Heat, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S921" CDS 2410593..2410973 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11092948; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390334.2" /db_xref="EnsemblGenomes-Gn:BSU24540" /db_xref="EnsemblGenomes-Tr:CAB14385" /db_xref="GOA:P54510" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG11700" /db_xref="UniProtKB/Swiss-Prot:P54510" /translation="MSNMIVLIIFAAFIIYMIASYVYQQRIMKTLTEEEFRAGYRKAQ LIDVREPNEFEGGHILGARNIPLSQLKQRKNEIRTDKPVYLYCQNSVRSGRAAQTLRK NGCTEIYNLKGGFKKWGGKIKAKK*" gene 2410593..2410973 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" downshifts 2410909 /Source="Nicolas_upshifts" /id="D1274" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17088" /MaxDrop="3.92673" /score="27.1863605" /energy="-12" /TU="U1909" /idTUdmin="U1909" /TUdmin="-44" /isTUend="FALSE" downshifts 2410953 /Source="Nicolas_upshifts" /id="D1275" /incds=0 /nref=213 /ntot=249 /MaxReadThrough="2.26861" /MaxDrop="6.03848" /score="27.1863605" /energy="-12" /TU="NA" /idTUdmin="U1909" /TUdmin=0 /isTUend="TRUE" CDS complement(2411008..2412474) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8181752, 20011599, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8181752, 20011599, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 2) (glycine cleavage system protein P)" /protein_id="NP_390335.1" /db_xref="EnsemblGenomes-Gn:BSU24550" /db_xref="EnsemblGenomes-Tr:CAB14386" /db_xref="GOA:P54377" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023012" /db_xref="SubtiList:BG11511" /db_xref="UniProtKB/Swiss-Prot:P54377" /translation="MSNQDQALIFELSREGRIGYSLPELDVPEIELGDLLSDTYIRDE DAALPEVSELDIMRHYTALSKRNHGVDSGFYPLGSCTMKYNPKINEKIARIPGFAAIH PLQDEDTVQGALELLYDLSKHLEEITGMDEVTLQPAAGAHGEWTGLMMIRAYHEARGD FKRTKVIVPDSAHGTNPASATVAGFETVTVKSNEKGLVDLEDLKRAVNEETAALMLTN PNTLGLFEEQITEMAEIVHQAGGKLYYDGANLNAVLSKARPGDMGFDVVHLNLHKTFT GPHGGGGPGSGPVGVKQDLIPYLPKPVLVKKEGRFTFDYDRPHAIGRVKPYYGNFGIN VRAYTYIRSMGPDGLKAVTENAVLNANYMMRKLAPYYDLPFDRHCKHEFVLSGKRQKK LGVRTLDIAKRLLDFGYHPPTIYFPLNVEECIMIEPTETESKETLDAFIDAMIQIAKE AEENPELVQEAPHTTIVKRMDETKAARHPVLRYEAEER*" gene complement(2411008..2412474) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" downshifts complement(2411028) /Source="Nicolas_upshifts" /id="D1276" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="3.45831" /MaxDrop="4.3142" /score="0.884126414" /energy="-12" /TU="U1911" /idTUdmin="U1911" /TUdmin="-1517" /isTUend="FALSE" CDS complement(2412467..2413813) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8181752, 20011599, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 1) (glycine cleavage system protein P)" /protein_id="NP_390336.2" /db_xref="EnsemblGenomes-Gn:BSU24560" /db_xref="EnsemblGenomes-Tr:CAB14387" /db_xref="GOA:P54376" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023010" /db_xref="SubtiList:BG11510" /db_xref="UniProtKB/Swiss-Prot:P54376" /translation="MKHRYLPATEKDKQEMLATIGVSSIDDLFADIPENVKYKKEHQI KKAKSETELTRELTKLASKNRDTVQYASFLGAGVYDHYQPVIVDHVISRSEFYTAYTP YQPEISQGELQAIFEFQTMICELTGMDIANSSMYDGGTALAEAAMLASGHTKKKKIVV SKTVHPESREVLKTYAKGQYIDVVEVPAADGVTDLDALRQTVCENTAAVIVQYPNFFG RIEPLKDIEPIAHQGKSMFIVSANPLALGLLTPPGKFQSDIVVGDAQPFGIPSAYGGP HCGFFAVTKKLMRKVPGRLVGQTEDENGKRGFVLTLQAREQHIRRDKATSNICSNQAL NALAASVAMTALGKNGVKDIARQNLLKANYAKQEAKKAGLTVMFDGPMFNEFVIKLDE PVRAVNKRLLAKGMIGGYDLGLTYPELDCHMLIAVTELRTKEEIDALIQELGDRHE*" gene complement(2412467..2413813) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" CDS complement(2413843..2414931) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" /EC_number="2.1.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8219277, 15472076, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8219277, 15472076, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminomethyltransferase (glycine cleavage system protein T)" /protein_id="NP_390337.2" /db_xref="EnsemblGenomes-Gn:BSU24570" /db_xref="EnsemblGenomes-Tr:CAB14388" /db_xref="GOA:P54378" /db_xref="InterPro:IPR006222" /db_xref="InterPro:IPR006223" /db_xref="InterPro:IPR013977" /db_xref="InterPro:IPR022903" /db_xref="InterPro:IPR028896" /db_xref="InterPro:IPR029043" /db_xref="PDB:1YX2" /db_xref="SubtiList:BG11509" /db_xref="UniProtKB/Swiss-Prot:P54378" /translation="MLKRTPLFDLYKEYGGKTIDFGGWELPVQFSSIKKEHEAVRTAA GLFDVSHMGEVEVSGNDSLSFLQRLMTNDVSALTPGRAQYTAMCYPDGGTVDDLLIYQ KGENRYLLVINASNIDKDLAWMKEHAAGDVQIDNQSDQIALLAVQGPKAEAILKNLTD ADVSALKPFAFIDEADISGRKALISRTGYTGEDGYEIYCRSDDAMHIWKKIIDAGDAY GLIPCGLGARDTLRFEAKLPLYGQELTRDITPIEAGIGFAVKHKKESDFFGKSVLSEQ KENGAKRKLVGLEMIEKGIPRHGYEVFQNGKSVGKVTTGTQSPTLGKNVGLALIDSET SEIGTVVDVEIRKKLVKAKVVKTPFYKR*" gene complement(2413843..2414931) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" misc_RNA complement(2415005..2415204) /gene="swgA" /locus_tag="BSU_misc_RNA_37" /product="dual aptamer glycine riboswitch" /experiment="publication(s) with functional evidences, PMID:15472076, 21439473, 23249744, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15472076, 21439473, 23249744, 23721735, 29089431; Product type n: RNA" gene complement(2415005..2415204) /gene="swgA" /locus_tag="BSU_misc_RNA_37" downshifts complement(2415055) /Source="Nicolas_upshifts" /id="D1277" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="6.79606" /MaxDrop="3.0322" /score="21.5485037" /energy="-20.2" /TU="U1911" /idTUdmin="U1915" /TUdmin=3630 /isTUend="FALSE" S_feature complement(2415205..2415275) /Source="Nicolas_S_feature" /locus_tag="new_2549607_2549677_c" /HighExp="B60, S8, S6, B36, S7, M9-stat, Sw, T3.0H, HiOs, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S922" promotor_-35 2415208..2415213 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2415229..2415247 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2415233 /Source="Nicolas_upshifts" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" S_feature 2415243..2415372 /Source="Nicolas_S_feature" /locus_tag="new_2549645_2549774" /HighExp="S4, S8, S7, S3, S5, S6, LoTm, T5.0H, T4.0H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.83" /TUlongSig="NA" /TUlongPSig="NA" /label="S923" promotor_-10 complement(2415261..2415280) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-10" upshifts complement(2415275) /Source="Nicolas_upshifts" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" promotor_-35 complement(2415294..2415301) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-35" CDS 2415373..2417046 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" /EC_number="3.6.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA polymerase-associated helicase protein" /protein_id="NP_390338.1" /db_xref="EnsemblGenomes-Gn:BSU24580" /db_xref="EnsemblGenomes-Tr:CAB14389" /db_xref="GOA:P54509" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11699" /db_xref="UniProtKB/Swiss-Prot:P54509" /translation="MNTEMIYDAKWPEEFAERLKNDGPWANWELYKLSAEIQKTLAIP EFEGLRAPLYLPSFTPLPHQLEVAQKVVEKMNGKAILADEVGLGKTVEAGLILKEYMI RGLAKKILILVPASLVSQWVKELQEKFLIPAVEQKKSYVWEQCDIVVSSIDTAKRSPH REIVLSIPYDLVIIDEAHKLKNSKTKNYEFVRNLVKKYCLLLTATPIQNRIEEIFNLV SLLKPGHLGSQNHFQEEFAKKKSSLEAHEHLKDLVNKVMIRNRRHDTGLNWKQRHVET VPIQFSPSEQALYDEISRLKDSINKPASMFSIMTLQRECCSSREAVYMTLKKMLDQKE KQAPAIDEDTISVLIDRINQVTQNSKALQVVDLIKKIDDKVIIFTEYRATQIYLQWFL QQNGISSVPFRGGFKRGKKDWMKDLFRGKIQVLIATEAGGEGINLQFCNHMINYDLPW NPMRLEQRIGRIHRLGQERDVHIYNMATKHTVEEHILKLLYEKIHLFEKVVGELDDIL TKIQVNNFEEHLHDILYHSATEEEMKIKMDNLTSFLSYKKQLPAEKRGS*" gene 2415373..2417046 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" CDS 2417067..2417861 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390339.1" /db_xref="EnsemblGenomes-Gn:BSU24590" /db_xref="EnsemblGenomes-Tr:CAB14390" /db_xref="InterPro:IPR024562" /db_xref="SubtiList:BG11698" /db_xref="UniProtKB/Swiss-Prot:P54508" /translation="MRQQEVHDFLLRFFQANSCQIVDQGLGYMTVQLTVEMDKQIMNR PFYWHWREKTGGDPNPMKITFITDKENAPKDLDGEFIYFGAPRLFQIFKAVKQNGRFT RMYEKIESAGAKVPLQPWLGINVTISYQSDMKKDKLLSLGLHLVSGTIIEDFQSKLTQ FSLTSQICDYCFTISPMIKPESGLKRMENYISKSAMQEPSDWAEQAVNRWKNDMTLLD KFYEHIEEKPEEYHLEKQALKTLYQPKISVEIENGGLFYLQNNISS*" gene 2417067..2417861 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" misc_feature 2417397..2417398 /Source="Nicolas_upshift_promotors" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2417403 /Source="Nicolas_upshifts" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" promotor_-35 2417885..2417888 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2417904..2417923 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2417905..2418043 /Source="Nicolas_S_feature" /locus_tag="new_2552307_2552445" /HighExp="LoTm, S4, S5, T5.0H, M9-stat, S3, B60, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.843, 0.83" /TUlongSig="SigA" /TUlongPSig="0.541" /label="S924" upshifts 2417905 /Source="Nicolas_upshifts" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" CDS 2418044..2418217 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antagonist of SinR" /protein_id="NP_390340.1" /db_xref="EnsemblGenomes-Gn:BSU24600" /db_xref="EnsemblGenomes-Tr:CAB14391" /db_xref="GOA:P23308" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="SubtiList:BG10753" /db_xref="UniProtKB/Swiss-Prot:P23308" /translation="MKNAKQEHFELDQEWVELMVEAKEANISPEEIRKYLLLNKKSAH PGPAARSHTVNPF*" gene 2418044..2418217 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" promotor_-35 2418202..2418206 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2418219..2418238 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2418219 /Source="Nicolas_upshifts" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" CDS 2418251..2418586 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator of biofilm formation" /protein_id="NP_390341.1" /db_xref="EnsemblGenomes-Gn:BSU24610" /db_xref="EnsemblGenomes-Tr:CAB14392" /db_xref="GOA:P06533" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="PDB:2YAL" /db_xref="PDB:3QQ6" /db_xref="PDB:3ZKC" /db_xref="SubtiList:BG10754" /db_xref="UniProtKB/Swiss-Prot:P06533" /translation="MIGQRIKQYRKEKGYSLSELAEKAGVAKSYLSSIERNLQTNPSI QFLEKVSAVLDVSVHTLLDEKHETEYDGQLDSEWEKLVRDAMTSGVSKKQFREFLDYQ KWRKSQKEE*" gene 2418251..2418586 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" downshifts 2418563 /Source="Nicolas_upshifts" /id="D1278" /incds=0 /nref=21 /ntot=181 /MaxReadThrough="4.7611" /MaxDrop="6.41889" /score="2.30357781" /energy="-20" /TU="U1913,U1914" /idTUdmin="U1910" /TUdmin="-2" /isTUend="TRUE" downshifts 2418653 /Source="Nicolas_upshifts" /id="D1279" /incds=0 /nref=1 /ntot=85 /MaxReadThrough="2.4376" /MaxDrop="4.25363" /score="58.1462301" /energy="-26.8" /TU="NA" /idTUdmin="U1913" /TUdmin=22 /isTUend="TRUE" CDS complement(2418679..2419464) /gene="tasA" /locus_tag="BSU_24620" /old_locus_tag="BSU24620" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464223, 10827084, 16430695, 16430696, 18047568, 23569226, 25326308, 27655338, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464223, 10827084, 16430695, 16430696, 18047568, 23569226, 25326308, 27655338, 28546427; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="major biofilm matrix component" /protein_id="NP_390342.1" /db_xref="EnsemblGenomes-Gn:BSU24620" /db_xref="EnsemblGenomes-Tr:CAB14393" /db_xref="GOA:P54507" /db_xref="InterPro:IPR022121" /db_xref="InterPro:IPR023833" /db_xref="SubtiList:BG11697" /db_xref="UniProtKB/Swiss-Prot:P54507" /translation="MGMKKKLSLGVASAALGLALVGGGTWAAFNDIKSKDATFASGTL DLSAKENSASVNLSNLKPGDKLTKDFQFENNGSLAIKEVLMALNYGDFKANGGSNTSP EDFLSQFEVTLLTVGKEGGNGYPKNIILDDANLKDLYLMSAKNDAAAAEKIKKQIDPK FLNASGKVNVATIDGKTAPEYDGVPKTPTDFDQVQMEIQFKDDKTKDEKGLMVQNKYQ GNSIKLQFSFEATQWNGLTIKKDHTDKDGYVKENEKAHSEDKN*" gene complement(2418679..2419464) /gene="tasA" /locus_tag="BSU_24620" /old_locus_tag="BSU24620" downshifts complement(2418685) /Source="Nicolas_upshifts" /id="D1280" /incds=0 /nref=144 /ntot=227 /MaxReadThrough="4.33009" /MaxDrop="8.70948" /score="10.0483516" /energy="-20" /TU="NA" /idTUdmin="U1915" /TUdmin=0 /isTUend="TRUE" misc_feature complement(2419517..2419534) /Source="Nicolas_upshift_promotors" /id="U1915" /multdbtbs="-" /comp="M14" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.478521478521479" /xcortree=2768 /SigmaFactorBS="agaaagacaaaagccttggaaacagatacaaaggacagcacc atgtcTACTTAACTTCAGTTGTAaacctggcaacaggtttcgatataaaatcattcaa t" /listShort="tasA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2419521) /Source="Nicolas_upshifts" /id="U1915" /multdbtbs="-" /comp="M14" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.478521478521479" /xcortree=2768 /SigmaFactorBS="agaaagacaaaagccttggaaacagatacaaaggacagcacc atgtcTACTTAACTTCAGTTGTAaacctggcaacaggtttcgatataaaatcattcaa t" /listShort="tasA" /GFF_Attribute="listLong" CDS complement(2419528..2420100) /gene="sipW" /locus_tag="BSU_24630" /old_locus_tag="BSU24630" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464223, 10559173, 10827084, 15101989, 16430695, 22328672, 26346121, 27655338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464223, 10559173, 10827084, 15101989, 16430695, 22328672, 26346121, 27655338; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_390343.1" /db_xref="EnsemblGenomes-Gn:BSU24630" /db_xref="EnsemblGenomes-Tr:CAB14394" /db_xref="GOA:P54506" /db_xref="InterPro:IPR001733" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11696" /db_xref="UniProtKB/Swiss-Prot:P54506" /translation="MKLISNILYVIIFTLIIVLTLVVISTRSSGGEPAVFGYTLKSVL SGSMEPEFNTGSLILVKEITDVKELQKGDVITFMQDANTAVTHRIVDITKQGDHLLFK TKGDNNAAADSAPVSDENVRAQYTGFQLPYAGYMLHFASQPIGTAVLLIVPGVMLLVY AFVTISSAIREIERKTKALETDTKDSTMST*" gene complement(2419528..2420100) /gene="sipW" /locus_tag="BSU_24630" /old_locus_tag="BSU24630" CDS complement(2420084..2420845) /gene="tapA" /locus_tag="BSU_24640" /old_locus_tag="BSU24640" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464223, 10559173, 14707086, 16430695, 17554552, 21477127, 24488317, 26441856, 26819068, 27655338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464223, 10559173, 14707086, 16430695, 17554552, 21477127, 24488317, 26441856, 26819068, 27655338; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein for biofilm formation" /protein_id="NP_390344.1" /db_xref="EnsemblGenomes-Gn:BSU24640" /db_xref="EnsemblGenomes-Tr:CAB14395" /db_xref="GOA:P40949" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR023833" /db_xref="InterPro:IPR023848" /db_xref="SubtiList:BG11076" /db_xref="UniProtKB/Swiss-Prot:P40949" /translation="MFRLFHNQQKAKTKLKVLLIFQLSVIFSLTAAICLQFSDDTSAA FHDIETFDVSLQTCKDFQHTDKNCHYDKRWDQSDLHISDQTDTKGTVCSPFALFAVLE NTGEKLKKSKWKWELHKLENARKPLKDGNVIEKGFVSNQIGDSLYKIETKKKMKPGIY AFKVYKPAGYPANGSTFEWSEPMRLAKCDEKPTVPKKETKSDVKKENETTQKDIPEKT MKEETSQEAVTKEKETQSDQKESGEEDEKSNEADQ*" gene complement(2420084..2420845) /gene="tapA" /locus_tag="BSU_24640" /old_locus_tag="BSU24640" promotor_-10 complement(2420905..2420924) /Source="Nicolas_upshift_promotors" /id="U1916" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.97002997002997" /xcortree=2769 /SigmaFactorBS="aaaacattcttttaaacgaacaaaatgagcgatttcggTGTT TTTAaatctataaatcgTTGATTATACTCTATTTGTGaagttctttaaagagaacgat t" /listShort="yqxM, sipW" /listLong="tasA" /label="promotor_-10" upshifts complement(2420923) /Source="Nicolas_upshifts" /id="U1916" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.97002997002997" /xcortree=2769 /SigmaFactorBS="aaaacattcttttaaacgaacaaaatgagcgatttcggTGTT TTTAaatctataaatcgTTGATTATACTCTATTTGTGaagttctttaaagagaacgat t" /listShort="yqxM, sipW" /listLong="tasA" promotor_-35 complement(2420938..2420945) /Source="Nicolas_upshift_promotors" /id="U1916" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.97002997002997" /xcortree=2769 /SigmaFactorBS="aaaacattcttttaaacgaacaaaatgagcgatttcggTGTT TTTAaatctataaatcgTTGATTATACTCTATTTGTGaagttctttaaagagaacgat t" /listShort="yqxM, sipW" /listLong="tasA" /label="promotor_-35" promotor_-35 2421067..2421073 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2421074 /Source="Nicolas_upshifts" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" promotor_-10 2421087..2421098 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2421117..2421443 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390345.1" /db_xref="EnsemblGenomes-Gn:BSU24650" /db_xref="EnsemblGenomes-Tr:CAB14396" /db_xref="InterPro:IPR024987" /db_xref="PDB:2LYX" /db_xref="SubtiList:BG13773" /db_xref="UniProtKB/Swiss-Prot:O32019" /translation="MMIKQCVICLSLLVFGTTAAHAEETPLVTARHMSKWEEIAVKEA KKRYPLAQVLFKQKVWDRKRKDEAVKQYHLTLREGSKEFGVFVTISFDPYSQKVNKIA ILEEYQ*" gene 2421117..2421443 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" S_feature complement(2421260..2421484) /Source="Nicolas_S_feature" /locus_tag="new_2555662_2555886_c" /HighExp="GM 150, G/S, C30, T-4.40H, S8, T-3.40H, Pyr, S7, S2, C90" /AntisenseName="yqzG" /AntisenseCor="0.536702817178903" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.549, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S925" downshifts complement(2421303) /Source="Nicolas_upshifts" /id="D1281" /incds=1 /nref=92 /ntot=160 /MaxReadThrough="2.23218" /MaxDrop="5.56661" /score="31.27773" /energy="-10.2" /TU="NA" /idTUdmin="U1918" /TUdmin=0 /isTUend="TRUE" downshifts 2421425 /Source="Nicolas_upshifts" /id="D1282" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="2.14107" /MaxDrop="4.98052" /score="-9.62570043" /energy="-15.1" /TU="NA" /idTUdmin="U1917" /TUdmin=0 /isTUend="TRUE" CDS complement(2421485..2421664) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="factor involved in sporulation" /protein_id="NP_390346.2" /db_xref="EnsemblGenomes-Gn:BSU24660" /db_xref="EnsemblGenomes-Tr:CAB14397" /db_xref="InterPro:IPR025622" /db_xref="SubtiList:BG13771" /db_xref="UniProtKB/Swiss-Prot:O32020" /translation="MKTNDYVKYMTQQFVKYIDTPRDERKERKEVRKETKTPVSQQWF GILPYGFRLWLKRKK*" gene complement(2421485..2421664) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" promotor_-10 complement(2421683..2421701) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2421698) /Source="Nicolas_upshifts" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" promotor_-35 complement(2421716..2421722) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2421735..2422109) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406, 24164455; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390347.1" /db_xref="EnsemblGenomes-Gn:BSU24670" /db_xref="EnsemblGenomes-Tr:CAB14398" /db_xref="GOA:P25959" /db_xref="InterPro:IPR020372" /db_xref="SubtiList:BG10489" /db_xref="UniProtKB/Swiss-Prot:P25959" /translation="MYRTRGFIYPAVLFVSALVLLIVNFVAAQYISRCMFEKETKELY IGENLLQNGVLLSIRHVLEERKGQEGTQQFLYGRVSYYIHDTSIKEQKEINLRVSTDS GTERTAQIVFDQKQKKLLRWTE*" gene complement(2421735..2422109) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" CDS complement(2422110..2422493) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390348.1" /db_xref="EnsemblGenomes-Gn:BSU24680" /db_xref="EnsemblGenomes-Tr:CAB14399" /db_xref="GOA:P25958" /db_xref="InterPro:IPR016977" /db_xref="SubtiList:BG10488" /db_xref="UniProtKB/Swiss-Prot:P25958" /translation="MLISGSLAAIIHLFLSRQQEHDGFTQQEWMISIEQMMNECKESQ AVKTAEHGSVLICTNLSGQDIRFDIYHSMIRKRVDGKGHVPILDHITAMKADIENGVV LLKIESEDQKVYQTAFPVYSYLGGG*" gene complement(2422110..2422493) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" CDS complement(2422519..2422866) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" /function="16.11: Scavenge (Catabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7783624, 9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390349.1" /db_xref="EnsemblGenomes-Gn:BSU24690" /db_xref="EnsemblGenomes-Tr:CAB14400" /db_xref="GOA:P25957" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR020488" /db_xref="SubtiList:BG10487" /db_xref="UniProtKB/Swiss-Prot:P25957" /translation="MWRENKGFSTIETMSALSLWLFVLLTVVPLWDKLMADEKMAESR EIGYQMMNESISKYVMSGEGAASKTITKNNHIYAMKWEEEGEYQNVCIKAAAYKEKSF CLSILQTEWLHAS*" gene complement(2422519..2422866) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" CDS complement(2422850..2423281) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane component of the DNA transport pilin platform" /protein_id="NP_390350.1" /db_xref="EnsemblGenomes-Gn:BSU24700" /db_xref="EnsemblGenomes-Tr:CAB14401" /db_xref="GOA:P25956" /db_xref="InterPro:IPR002416" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016785" /db_xref="SubtiList:BG10486" /db_xref="UniProtKB/Swiss-Prot:P25956" /translation="MNIKLNEEKGFTLLESLLVLSLASILLVAVFTTLPPAYDNTAVR QAASQLKNDIMLTQQTAISRQQRTKILFHKKEYQLVIGDTVIERPYATGLSIELLTLK DRLEFNEKGHPNAGGKIRVKGHAVYDITVYLGSGRVNVERK*" gene complement(2422850..2423281) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" CDS complement(2423271..2423567) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="pilin-like component of the DNA transport membrane pilin platform" /protein_id="NP_390351.1" /db_xref="EnsemblGenomes-Gn:BSU24710" /db_xref="EnsemblGenomes-Tr:CAB14402" /db_xref="GOA:P25955" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016940" /db_xref="SubtiList:BG10485" /db_xref="UniProtKB/Swiss-Prot:P25955" /translation="MNEKGFTLVEMLIVLFIISILLLITIPNVTKHNQTIQKKGCEGL QNMVKAQMTAFELDHEGQTPSLADLQSEGYVKKDAVCPNGKRIIITGGEVKVEH*" gene complement(2423271..2423567) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" CDS complement(2423581..2424552) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 15968048, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 15968048, 16850406, 24164455; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane pilin platform component of the DNA transport machinery" /protein_id="NP_390352.1" /db_xref="EnsemblGenomes-Gn:BSU24720" /db_xref="EnsemblGenomes-Tr:CAB14403" /db_xref="GOA:P25954" /db_xref="InterPro:IPR001992" /db_xref="InterPro:IPR018076" /db_xref="SubtiList:BG10484" /db_xref="UniProtKB/Swiss-Prot:P25954" /translation="MTAGGYTLLDGLRLMELQMNKRQAADLTDSVTCLREGAPFYQVL KSLSFHKEAVGICYFAETHGELPASMIQSGELLERKIAQADQLKRVLRYPLFLIFTVA VMFYMLQSIIIPQFSGIYQSMNMETSRSTDMLFAFFQHIDLVIILLVLFTAGIGIYYW LVFKKKSPARQMLICIRIPLVGKLVKLFNSYFFSLQLSSLLKSGLSIYDSLNAFKHQT FLPFYRCEAEQLIERLKAGESIESAICGSLFYETDLSKVISHGQLSGRLDRELFTYSQ FILQRLEHKAQKWTGILQPMIYGFVAAMILLVYLSMLVPMYQMMNQM*" gene complement(2423581..2424552) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" CDS complement(2424605..2425675) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane associated ATPase of the pilin platformfor DNA competence" /protein_id="NP_390353.1" /db_xref="EnsemblGenomes-Gn:BSU24730" /db_xref="EnsemblGenomes-Tr:CAB14404" /db_xref="GOA:P25953" /db_xref="InterPro:IPR001482" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10483" /db_xref="UniProtKB/Swiss-Prot:P25953" /translation="MDSIEKVSKNLIEEAYLTKASDIHIVPRERDAIIHFRVDHALLK KRDMKKEECVRLISHFKFLSAMDIGERRKPQNGSLTLKLKEGNVHLRMSTLPTINEES LVIRVMPQYNIPSIDKLSLFPKTGATLLSFLKHSHGMLIFTGPTGSGKTTTLYSLVQY AKKHFNRNIVTLEDPVETRDEDVLQVQVNEKAGVTYSAGLKAILRHDPDMIILGEIRD AETAEIAVRAAMTGHLVLTSLHTRDAKGAIYRLLEFGINMNEIEQTVIAIAAQRLVDL ACPFCENGCSSVYCRQSRNTRRASVYELLYGKNLQQCIQEAKGNHANYQYQTLRQIIR KGIALGYLTTNNYDRWVYHEKD*" gene complement(2424605..2425675) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" promotor_-10 complement(2425693..2425712) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2425709) /Source="Nicolas_upshifts" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" promotor_-35 complement(2425726..2425733) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2425858..2426086) /Source="Nicolas_S_feature" /locus_tag="new_2560260_2560488_c" /HighExp="Etha, Salt, Sw, Gly, LPhT, B36, Heat, B60, LoTm, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37350499999999998" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S926" downshifts complement(2425899) /Source="Nicolas_upshifts" /id="D1283" /incds=0 /nref=16 /ntot=42 /MaxReadThrough="0.95925" /MaxDrop="5.92871" /score="30.7083619" /energy="-13" /TU="NA" /idTUdmin="U1920" /TUdmin=1 /isTUend="TRUE" CDS complement(2426087..2427040) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15856219, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15856219, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="CorA-type divalent ion transporter" /protein_id="NP_390354.1" /db_xref="EnsemblGenomes-Gn:BSU24740" /db_xref="EnsemblGenomes-Tr:CAB14405" /db_xref="GOA:P40948" /db_xref="InterPro:IPR002523" /db_xref="SubtiList:BG11075" /db_xref="UniProtKB/Swiss-Prot:P40948" /translation="MKAHTGKDWFWYQMGPQERSKARDLIHFSHWPQCEKWFENNHHV NFLRVDTTETENEAVFGSIVYDQGLGEEKDHTVFHFYITRQYFFTINFDFSILREIKG KEVVRQMERADNAIEGFLILLGELMNAYLIGVDEFEVKLRKLRWQIKDDNSKSILNRV HLLRHELMIWKNLILSAKKIEMALKETFLPQNEGKKDYQRTQLKIDRGFTYISEFEGE LNNLLHSEEVITSHRGNEIVKALTIFTTLFTPITALGALWGMNFSVMPELNWKYGYLF SLLLIVTSTVLIYLYLRKKGWTGDMLQERKKKKKPRKRRTL*" gene complement(2426087..2427040) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" promotor_-10 complement(2427064..2427083) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2427085) /Source="Nicolas_upshifts" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" promotor_-35 complement(2427097..2427103) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2427123..2427129 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2427144..2427162 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2427162 /Source="Nicolas_upshifts" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" CDS 2427183..2428511 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane associated enzyme" /protein_id="NP_390355.1" /db_xref="EnsemblGenomes-Gn:BSU24750" /db_xref="EnsemblGenomes-Tr:CAB14406" /db_xref="GOA:P54505" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG11695" /db_xref="UniProtKB/Swiss-Prot:P54505" /translation="MPSLEKAVVLEFINLLAVAILILLTGFFVAVEFSIVKVRRSKID QLVAKGKKGAKAAKHVITHLDEYLSACQLGITVAALGLGWLGEPTVQTLLRPLFHKAG LNESLTHLLSLVIAFLVVTYLNVVIGELAPKSFAIQKAESITLLFAKPLIWFYKIMFP FIWLLNHSARLITGVFGLKPASEHELAYTEEELRVLLAESYKSGEIRKSELKYMNNIF TFDKRMAKEIMVPRNEMVSLSLDEDSISNLQETVKQTKYTRYPVVREDKDNVIGVINM KEVLFSMLTKDFSIKKHQIEPFVQPVIHVIETIPIYKLLLKMQKERTHMAILIDEYGG TSGLVTVEDIIEEIVGEIRDEFDADEVPHIRELGKDHYLLNAKLLISDVNSLLGTDLS EAEVDTLGGWFLTQNIDAEPESAIEYDGYSFKVKDINSHHILFIEVKKAE*" gene 2427183..2428511 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" S_feature 2428512..2429486 /Source="Nicolas_S_feature" /locus_tag="new_2562914_2563888" /HighExp="Sw, Salt, Etha, LPhT, M9-stat, S8, BC, S6, BT, Gly" /AntisenseName="rsbRD" /AntisenseCor="0.58358076577781004" /AntisenseRegPval="-25.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S927" CDS complement(2428564..2429400) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11157946, 15312768, 15583165, 16963570, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157946, 15312768, 15583165, 16963570, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_390356.2" /db_xref="EnsemblGenomes-Gn:BSU24760" /db_xref="EnsemblGenomes-Tr:CAB14407" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR025751" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11694" /db_xref="UniProtKB/Swiss-Prot:P54504" /translation="MIALDQHLTEHKKDITQQWLEVCTSNGSWLYSAKDQQKLEQKLK DQHELLVTIVAKSLRKEDVEDELNRWSLQCARDRAVHEVTVTQSVGQFNTFRHIMFEW IHKFSEASSQDISIQEFYEWSRILNQNIDEIIEVFTEEYHQVTMIQLNAQKEMINELS APIMPITDGIGILPLVGEIDTHRARTILESVLEQCSALKLSYLFLDISGVPIVDTMVA YQIFKVIDSTKLLGIETIISGIRPEIAQTVVKLGLDFSNVKTEQSLAKALANKGFKIK EC*" gene complement(2428564..2429400) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" S_feature complement(2429401..2429585) /Source="Nicolas_S_feature" /locus_tag="new_2563803_2563987_c" /HighExp="Etha, LoTm, Salt, Heat, Gly, M9-stat, B60, S8, S0, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147982" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S928" tRNA 2429487..2429557 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln (UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" gene 2429487..2429557 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" CDS complement(2429624..2430004) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:18643936, 22812682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18643936, 22812682; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of stress" /protein_id="NP_390357.2" /db_xref="EnsemblGenomes-Gn:BSU24770" /db_xref="EnsemblGenomes-Tr:CAB14408" /db_xref="GOA:P54503" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11693" /db_xref="UniProtKB/Swiss-Prot:P54503" /translation="MEQQLTFYSYPSCTSCRKTKHWLKAHQIEFNERHLFRETPTREE LKYILSLTTEGIDEILATRSQTFKNLNLNIEEMTVNEVLELLIEKPKLLRRPILVDNK KLVIGYNPGELLKLSKKKTVHQSA*" gene complement(2429624..2430004) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" downshifts complement(2429630) /Source="Nicolas_upshifts" /id="D1284" /incds=0 /nref=9 /ntot=174 /MaxReadThrough="6.12556" /MaxDrop="6.72616" /score="0.164931099" /energy="-19.7" /TU="U1922" /idTUdmin="U1925" /TUdmin=912 /isTUend="FALSE" promotor_-10 complement(2430033..2430051) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2430052) /Source="Nicolas_upshifts" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" promotor_-35 complement(2430066..2430072) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2430091..2430096 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-35" promotor_-10 2430112..2430130 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-10" upshifts 2430121 /Source="Nicolas_upshifts" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" promotor_-35 2430171..2430178 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-35" upshifts 2430193 /Source="Nicolas_upshifts" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" promotor_-10 2430194..2430213 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-10" CDS 2430236..2430481 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390358.1" /db_xref="EnsemblGenomes-Gn:BSU24780" /db_xref="EnsemblGenomes-Tr:CAB14409" /db_xref="GOA:P54502" /db_xref="InterPro:IPR020254" /db_xref="SubtiList:BG11692" /db_xref="UniProtKB/Swiss-Prot:P54502" /translation="MNRMFRVLGFWTGIFAVMFYLGDMKDASLLFFGQTILFVFLSYL NLTERMYIYIFGAYLTIFFAGFTYYSIFIMVPGGGGH*" gene 2430236..2430481 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" downshifts 2430378 /Source="Nicolas_upshifts" /id="D1285" /incds=1 /nref=1 /ntot=86 /MaxReadThrough="6.68961" /MaxDrop="2.1025" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=176 /isTUend="FALSE" downshifts 2430467 /Source="Nicolas_upshifts" /id="D1286" /incds=0 /nref=98 /ntot=234 /MaxReadThrough="4.03872" /MaxDrop="5.76938" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=265 /isTUend="FALSE" S_feature 2430512..2431267 /Source="Nicolas_S_feature" /locus_tag="new_2564914_2565669" /HighExp="M9-stat, T0.30H, T1.30H, LoTm, T1.0H, B60, T2.0H, S5, S4, T2.30H" /AntisenseName="yqgX" /AntisenseCor="-0.68109878166952498" /AntisenseRegPval="-37.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S929" CDS complement(2430521..2431156) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20669241, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-binding hydrolase" /protein_id="NP_390359.1" /db_xref="EnsemblGenomes-Gn:BSU24790" /db_xref="EnsemblGenomes-Tr:CAB14410" /db_xref="GOA:P54501" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11691" /db_xref="UniProtKB/Swiss-Prot:P54501" /translation="MKWRRMPVGPIQANAYFLISDDQCLIFDPGGEGHKINQYIKEKG LTPLAILLTHAHFDHIGALDEVREKWDIPVYLHQNEKNWLADASLNGSGMLRGIEVTA KPADHLIEGDGELNIGPFHLETLFTPGHSPGSVSYYVKDADLVISGDVLFQGGIGRTD LIGGNQETLLTSIHEKLLTLPEHTLVLSGHGPETDVLTEQDQNPFLNGFSL*" gene complement(2430521..2431156) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" downshifts complement(2430546) /Source="Nicolas_upshifts" /id="D1287" /incds=0 /nref=154 /ntot=239 /MaxReadThrough="1.42757" /MaxDrop="5.15622" /score="-8.36666809" /energy="-13.7" /TU="NA" /idTUdmin="U1925" /TUdmin="-4" /isTUend="TRUE" promotor_-10 complement(2431178..2431197) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2431195) /Source="Nicolas_upshifts" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" promotor_-35 complement(2431211..2431218) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2431235..2431242 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2431257..2431276 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2431269 /Source="Nicolas_upshifts" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" upshifts complement(2431289) /Source="Nicolas_upshifts" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2431291..2431305) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2431313..2431317) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2431313..2431486 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390360.1" /db_xref="EnsemblGenomes-Gn:BSU24800" /db_xref="EnsemblGenomes-Tr:CAB14411" /db_xref="GOA:P54500" /db_xref="InterPro:IPR024490" /db_xref="SubtiList:BG11690" /db_xref="UniProtKB/Swiss-Prot:P54500" /translation="MLLVVIFGLVALFALWGVLRSVRNKNILGFLLAGATLFVFGWFT VMTVINSGYPTAH*" gene 2431313..2431486 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" downshifts 2431474 /Source="Nicolas_upshifts" /id="D1288" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="3.92092" /MaxDrop="7.18555" /score="14.1643615" /energy="-12.4" /TU="U1926" /idTUdmin="U1924" /TUdmin=217 /isTUend="FALSE" CDS complement(2431518..2431832) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390361.2" /db_xref="EnsemblGenomes-Gn:BSU24810" /db_xref="EnsemblGenomes-Tr:CAB14412" /db_xref="GOA:P54499" /db_xref="InterPro:IPR002767" /db_xref="InterPro:IPR029756" /db_xref="SubtiList:BG11689" /db_xref="UniProtKB/Swiss-Prot:P54499" /translation="MAIADVTIIPIGTETPSVSAYVADVQKILEGYQAEGKIKYQLTP MNTLIEGELSDLFAVIQAIHEAPFQKGLHRVATNIRIDDRRDKKTTLESKIESVNKHL QP*" gene complement(2431518..2431832) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" S_feature 2431519..2432586 /Source="Nicolas_S_feature" /locus_tag="new_2565921_2566988" /HighExp="LoTm, M9-stat, C30, Cold, S8, S7, B60, Lbstat, G135, C90" /AntisenseName="yqgV" /AntisenseCor="-0.23995763414552801" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigEF" /TUlongPSig="1, 1" /label="S930" downshifts complement(2431532) /Source="Nicolas_upshifts" /id="D1289" /incds=0 /nref=247 /ntot=265 /MaxReadThrough="2.24429" /MaxDrop="6.85096" /score="0.185625845" /energy="-12.4" /TU="NA" /idTUdmin="U1928" /TUdmin="-1" /isTUend="TRUE" CDS complement(2431835..2432896) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390362.2" /db_xref="EnsemblGenomes-Gn:BSU24820" /db_xref="EnsemblGenomes-Tr:CAB14413" /db_xref="GOA:P54498" /db_xref="SubtiList:BG11688" /db_xref="UniProtKB/Swiss-Prot:P54498" /translation="MLMRSVCFILLAVLLFSLSACEPSHQQQKQASAAKDEKKDIIPL SAEKADGAEGWLNNSTILYTASNPTKTELFAYRIFTGKAKKLYQTDGQIVDVQINARE QMILLQITHSQKTAVVLLNAEGETLYEKDYETYELEAAWNQYDPYQMMVTEFNENWDF HTYQVNAKKDESFLSPVQVPFIHWTSKNTFDYVKEGRDDKTGPLYTFDTASKTEQKLE DNVLFFDSFHQMSFTVKSASGGKGTYQFKTPQSTSPVTAKWPLQAKYTSLAPMEYDYD EAGGLFYTFKQSGDAYKLAAINVASGETKDLVSLREMEPIQISPNGKYALYGFHFEQI ILLKSHETKQLIIDQKEME*" gene complement(2431835..2432896) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" CDS complement(2432958..2434088) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12765833, 24163346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative d,l-endopeptidase" /protein_id="NP_390363.1" /db_xref="EnsemblGenomes-Gn:BSU24830" /db_xref="EnsemblGenomes-Tr:CAB14414" /db_xref="GOA:P54497" /db_xref="InterPro:IPR000834" /db_xref="InterPro:IPR034274" /db_xref="SubtiList:BG11687" /db_xref="UniProtKB/Swiss-Prot:P54497" /translation="MMAFITVKPEIKNNLANVAKELKIDEELLKSANRSAQKHQLYCP GYVIEEHSGKELQTIQDIKRFLQPRQLKLSDSWIEQEKIYDDSAVEKEIKKIIDVFPF VSCREIGRSVLGRPIWELKAGGEHAVKKVHMNASFHANEWITTSVLLKWFKEYCMSLC CNSPFFGFSPIKLFNSTSLSLVPLVNPDGVDLVLNGSEVMGARRDELERLNEHRPNFN EWKANINGVDLNKQFPSLWEIEKYRKPTAPSYRDFPGISPLTEPESIAMYRLITENPP DRLLALHTQGEEIYWGYKGLEPEESAAVIKEFEELSGNIYKGVRDIDSYAGFRDWFIH HYFKEGYTVELGKGQNPLPFQQFSHIYNATSGILWRALFFHE*" gene complement(2432958..2434088) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" promotor_-10 complement(2434096..2434114) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2434128) /Source="Nicolas_upshifts" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" promotor_-35 complement(2434130..2434135) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2434171..2436087) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647, 25666134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647, 25666134; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_390364.2" /db_xref="EnsemblGenomes-Gn:BSU24840" /db_xref="EnsemblGenomes-Tr:CAB14415" /db_xref="GOA:P54496" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG11686" /db_xref="UniProtKB/Swiss-Prot:P54496" /translation="MRKTFFSKISFMLIAILLMWLKTYAVYKTSFHIKIDNLTQEFIL FINPLSFLLLIFGLSLFLKGKNRNRYIIAMSCLVTFVLLANMVFYRFYNDFLTIPVLF QTSNMGDLGSSIGTLLEPTDLLLAVDIAVLIWLHIRQKAFQSDIPSTKNERAAYFLFV ASVYFFNLGLSEAERPQLLTRSFDREMLVKNISLFNFHIYDGVLQSKQSAQRALADSN SLTEIENYVTANAKDANKRLFGAAKGRNVILVSLESTQSFVINEKLNGEEITPFLNDF IKQSYNFNNVYHQTGQGKTSDSEFIVDNSLYPLGRGAVFFTNAGNQYMAAPEILKNSG YYSAVLHANNKSFWNRDLMYDSFGYDSFFDINSYDVTDENSVGWGLKDKEFFEQSSEL MKNLPQPFYSRLITLTNHFPFDLDEEDQLIDEYDSNSQTLNKYFPTVRYQDEALKRFI EKLKEDGLYDNSVIVLYGDHYGISENHNEAMGQFLGKEITPFEEVQLQKVPLVIHIPG ITDKKPQTIETVGGQIDIRPTLMNLLGIDTKDQIQFGNDLLSDEKLDFTVLRDGSFIT DQVVYTDGACYDKETGKPLEETKQCEAFADKAKQELSLSDEIIYGDLLRFYDQKRLDN SSKRKEKQMLDQAS*" gene complement(2434171..2436087) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" downshifts complement(2434198) /Source="Nicolas_upshifts" /id="D1290" /incds=0 /nref=5 /ntot=142 /MaxReadThrough="4.5611" /MaxDrop="3.8416" /score="15.4764643" /energy="-14.5" /TU="U1930,U1931" /idTUdmin="U1928" /TUdmin="-2667" /isTUend="FALSE" promotor_-35 2435203..2435209 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2435222..2436251 /Source="Nicolas_S_feature" /locus_tag="new_2569624_2570653" /HighExp="Etha, Gly, M9-stat, Salt, S8, LPhT, S7, Sw, HiTm, B60" /AntisenseName="yqgS" /AntisenseCor="-0.36996929809172002" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S931" upshifts 2435222 /Source="Nicolas_upshifts" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" promotor_-10 2435225..2435243 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(2436088..2436154) /Source="Nicolas_S_feature" /locus_tag="new_2570490_2570556_c" /HighExp="T-3.40H, BC, Sw, S5, Lbstat, T-5.40H, S4, ferm, C30, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S932" promotor_-10 complement(2436148..2436167) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2436154) /Source="Nicolas_upshifts" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" promotor_-35 complement(2436182..2436189) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2436204..2437169) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" /EC_number="2.7.1.59" /EC_number="2.7.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose kinase" /protein_id="NP_390365.2" /db_xref="EnsemblGenomes-Gn:BSU24850" /db_xref="EnsemblGenomes-Tr:CAB14416" /db_xref="GOA:P54495" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR004654" /db_xref="SubtiList:BG11685" /db_xref="UniProtKB/Swiss-Prot:P54495" /translation="MDEIWFAGIDLGGTTIKLAFINQYGEIQHKWEVPTDKTGDTITV TIAKTIDSKLDELQKPKHIIKYIGMGAPGPVDMAAGVVYETVNLGWKNYALKNHLETE TGIPAVIENDANIAALGEMWKGAGDGAKDVILVTLGTGVGGGIIANGEIVHGINGAGG EIGHICSIPEGGAPCNCGKTGCIETIASATGIVRIAKEKIANAKKTTRLKATEQLSAR DVFEAAGENDEIALEVVDYVAKHLGLVLGNLASSLNPSKIVLGGGVSRAGELLRSKVE KTFRKCAFPRAAQAADISIAALGNDAGVIGGAWIAKNEWLKHQNC*" gene complement(2436204..2437169) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" CDS complement(2437180..2437395) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" /function="9.3: Transcription factors" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15050034, 20057058; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative single strand nucleic acid binding transcription factor" /protein_id="NP_390366.1" /db_xref="EnsemblGenomes-Gn:BSU24860" /db_xref="EnsemblGenomes-Tr:CAB14417" /db_xref="InterPro:IPR009256" /db_xref="InterPro:IPR023164" /db_xref="PDB:2NN4" /db_xref="SubtiList:BG11684" /db_xref="UniProtKB/Swiss-Prot:P54494" /translation="MNTFYDVQQLLKTFGHIVYFGDRELEIEFMLDELKELYMNHMIE KEQWARAAAVLRKELEQTKNGRDFYKG*" gene complement(2437180..2437395) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" S_feature complement(2437396..2437504) /Source="Nicolas_S_feature" /locus_tag="new_2571798_2571906_c" /HighExp="M0t90, Lbstat, M40t90, M40t45, Lbtran, Mt0, dia5, Diami, M0t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S933" CDS complement(2437505..2439028) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" /EC_number="3.4.21.105" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15050034, 16355228, 23518036, 26858402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane endopeptidase" /protein_id="NP_390367.2" /db_xref="EnsemblGenomes-Gn:BSU24870" /db_xref="EnsemblGenomes-Tr:CAB14418" /db_xref="GOA:P54493" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG11683" /db_xref="UniProtKB/Swiss-Prot:P54493" /translation="MFLLEYTYWKIAAHLVNSGYGVIQAGESDEIWLEAPDKSSHDLV RLYKHDLDFRQEMVRDIEEQAERVERVRHQLGRRRMKLLNVFFSTEAPVDDWEEIAKK TFEKGTVSVEPAIVRGTMLRDDLQAVFPSFRTEDCSEEHASFENAQMARERFLSLVLK QEEQRKTEAAVFQNGKPTFTYLFIALQILMFFLLEINGGSTNTETLVAFGAKENSLIA QGEWWRLLTPIVLHIGIAHLAFNTLALWSVGTAVERMYGSGRFLLIYLAAGITGSIAS FVFSPYPSAGASGAIFGCLGALLYVALSNRKMFLRTIGTNIIVIIIINLGFGFAVSNI DNSGHIGGLIGGFFAAAALGLPKAGAFGKRLLSAVLLIALAVGFLYYGLHSPSHQESA LIQQASELYQEGKYEEVTELLNGEAAQKDASADLLKILAVSDIQIGEYDQAVSLLERA VKKEPKDHASYYNLALLYAEKNELAQAEKAIQTAVKLKPKEQRYKELQRQIENNKES* " gene complement(2437505..2439028) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" promotor_-10 complement(2439046..2439065) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2439059) /Source="Nicolas_upshifts" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" promotor_-35 complement(2439080..2439087) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2439118..2439291) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390368.1" /db_xref="EnsemblGenomes-Gn:BSU24880" /db_xref="EnsemblGenomes-Tr:CAB14419" /db_xref="SubtiList:BG11682" /db_xref="UniProtKB/Swiss-Prot:P54492" /translation="MKKLLIYAIFAVSAVMFYQNRYRLMNTVLSQPGIRRSFIHLFLR IPFIRNKFIQQAF*" gene complement(2439118..2439291) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" downshifts complement(2439145) /Source="Nicolas_upshifts" /id="D1291" /incds=0 /nref=121 /ntot=211 /MaxReadThrough="2.93694" /MaxDrop="5.6047" /score="19.2452946" /energy="-8.9" /TU="NA" /idTUdmin="U1932" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2439307..2439318) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2439319) /Source="Nicolas_upshifts" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" promotor_-35 complement(2439332..2439338) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2439358..2439921) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" /EC_number="6.3.3.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17329806, 20952389, 22773193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-formyltetrahydrofolate cyclo-ligase" /protein_id="NP_390369.1" /db_xref="EnsemblGenomes-Gn:BSU24890" /db_xref="EnsemblGenomes-Tr:CAB14420" /db_xref="GOA:P54491" /db_xref="InterPro:IPR002698" /db_xref="PDB:1YDM" /db_xref="SubtiList:BG11681" /db_xref="UniProtKB/Swiss-Prot:P54491" /translation="MKSQLRKKTLEALSALSNEDILQKTERMYKYLFSLPEWQNAGTI AVTISRGLEIPTRPVIEQAWEEGKQVCIPKCHPDTKKMQFRTYQTDDQLETVYAGLLE PVIEKTKEVNPSQIDLMIVPGVCFDVNGFRVGFGGGYYDRYLSEYEGKTVSLLLECQL FAHVPRLPHDIPVHKLITEDRIISCFS*" gene complement(2439358..2439921) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" S_feature complement(2439922..2440005) /Source="Nicolas_S_feature" /locus_tag="new_2574324_2574407_c" /HighExp="Cold, G180, LBGexp, LBGtran, G135, HPh, LPh, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S934" CDS complement(2440006..2440155) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12904577, 19648245, 22720735, 23002217, 27561249; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_570908.2" /db_xref="EnsemblGenomes-Gn:BSU24900" /db_xref="EnsemblGenomes-Tr:CAE01461" /db_xref="GOA:P56849" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG14180" /db_xref="UniProtKB/Swiss-Prot:P56849" /translation="MRVNITLACTECGERNYISKKNKRNNPDRVEFKKYCPRDKKSTL HRETK*" gene complement(2440006..2440155) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" downshifts complement(2440052) /Source="Nicolas_upshifts" /id="D1292" /incds=0 /nref=154 /ntot=253 /MaxReadThrough="5.3064" /MaxDrop="4.5881" /score="34.7393253" /energy="-15.3" /TU="U1933" /idTUdmin="U1932" /TUdmin="-907" /isTUend="FALSE" promotor_-10 complement(2440192..2440211) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2440202) /Source="Nicolas_upshifts" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" promotor_-35 complement(2440227..2440230) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2440239..2441318) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_390370.2" /db_xref="EnsemblGenomes-Gn:BSU24910" /db_xref="EnsemblGenomes-Tr:CAB14421" /db_xref="GOA:P54490" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11680" /db_xref="UniProtKB/Swiss-Prot:P54490" /translation="MNILMLSPEHPDEPKSGLGVHLNRLISYLNPHINITVFTPSGQL FSYAKFEDYIADANFTMVRHVLSHNKRFDLIHAHDDTTAPAAQYLKQRLGLPLAATIH GLESERKKVCREAPHPYRLMTERLLIESADALIVLSTFMKRSLDKAAHKKITVIPSPA SMEEEKGKIPRSMNRRFLFSYGRFVPEKGLSQLLKVFAILKQRQPDLYLVLAGEGPSL SCYEKLAAAYNLKDRVMFLPFLNRKDIRTLLSHCEMAVFPSSYEPFGLAAQESMEQGV LTVVSQSGGFCDYAVHDKTAIIADFTLVQEAADLLDSFLKDREKARRIKEAGRQQVFK LHHPRLIMSSYLQLYERIFNNSAIH*" gene complement(2440239..2441318) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" CDS complement(2441315..2441785) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390371.1" /db_xref="EnsemblGenomes-Gn:BSU24920" /db_xref="EnsemblGenomes-Tr:CAB14422" /db_xref="SubtiList:BG11679" /db_xref="UniProtKB/Swiss-Prot:P54489" /translation="MDKHPFPYNIRHKLSFFRDTFDIIIQNAHTLTVSWEISEETMRL AEAVLFEKTQDMIKELRIVIKRKDIEAVRTKRTTYDKGEWTIRQAAGDAVYRAEYRIV NSMNVSLKLAGTDDIYLDENGIRHINSFQIEEAHTRWEAQFSAYTCYGRGEKER*" gene complement(2441315..2441785) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" promotor_-35 2441730..2441738 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2441752..2441760 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2441753..2441926 /Source="Nicolas_S_feature" /locus_tag="new_2576155_2576328" /HighExp="M9-stat, T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, Lbstat, T3.30H, B60" /AntisenseName="yqgL" /AntisenseCor="0.210779859401483" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S935" upshifts 2441754 /Source="Nicolas_upshifts" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" promotor_-10 complement(2441821..2441840) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2441833) /Source="Nicolas_upshifts" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" promotor_-35 complement(2441852..2441859) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2441898..2441902 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2441918..2441937 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2441928 /Source="Nicolas_upshifts" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" CDS 2441965..2442318 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390372.1" /db_xref="EnsemblGenomes-Gn:BSU24930" /db_xref="EnsemblGenomes-Tr:CAB14423" /db_xref="GOA:O32022" /db_xref="SubtiList:BG13770" /db_xref="UniProtKB/Swiss-Prot:O32022" /translation="MEIAIIALFIVSIALIAFSYSQRDPMKDVEQELETLQLSAMQEI YKLKKKMTVLEEELLETNLVIRKSKQNDINQKIAKQILSKYNNGMSAEAIAKAEHVSV EDVNTIIKDNEKVLV*" gene 2441965..2442318 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" CDS 2442315..2442779 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390373.2" /db_xref="EnsemblGenomes-Gn:BSU24940" /db_xref="EnsemblGenomes-Tr:CAB14424" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13769" /db_xref="UniProtKB/Swiss-Prot:O32023" /translation="MTKRGIQAFAGGIILATAVLAAVFYLTDEDQAAAVKDNKTVTEQ DVNNYLDSKKLVSVNRDEYQKLLDSKEKSLNNDSGSDTKSDKVKTYKLTIKDGMSTAD VSAILEKEGIISSAQDFNDYVIDAGYHKEIRAGEFKVKSDMSFKKIVKTLTR*" gene 2442315..2442779 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" downshifts 2442765 /Source="Nicolas_upshifts" /id="D1293" /incds=0 /nref=216 /ntot=264 /MaxReadThrough="0.9847" /MaxDrop="6.07831" /score="21.2108939" /energy="-8.8" /TU="NA" /idTUdmin="U1934" /TUdmin=0 /isTUend="TRUE" CDS complement(2442808..2443590) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390374.1" /db_xref="EnsemblGenomes-Gn:BSU24950" /db_xref="EnsemblGenomes-Tr:CAB14425" /db_xref="GOA:P46342" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11379" /db_xref="UniProtKB/Swiss-Prot:P46342" /translation="MSIATEAVMKQEVYQVNGMNLWYGQHHALKNINLSIYENEVTAI IGPSGCGKSTFIKTLNLMIQMTPNVKLAGELNYNGSNILKDKVDIVDLRKNIGMVFQK GNPFPQSIFDNVAYGPRVHGTKNKKKLQEIVEKSLKDVALWDEVKDRLHTSALSLSGG QQQRLCIARALATNPDILLMDEPTSALDPISTRKIEELILELKDKYTIVIVTHNMQQA ARVSDQTAFFYMGELVECDNTNKMFSNPKDQRTLDYISGKFG*" gene complement(2442808..2443590) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" downshifts complement(2442819) /Source="Nicolas_upshifts" /id="D1294" /incds=0 /nref=20 /ntot=46 /MaxReadThrough="2.29658" /MaxDrop="6.53816" /score="26.1659198" /energy="-8.8" /TU="NA" /idTUdmin="U1937" /TUdmin=0 /isTUend="TRUE" CDS complement(2443601..2444410) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390375.1" /db_xref="EnsemblGenomes-Gn:BSU24960" /db_xref="EnsemblGenomes-Tr:CAB14426" /db_xref="GOA:P46341" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11378" /db_xref="UniProtKB/Swiss-Prot:P46341" /translation="MSEQMVKEKPERAVIVPKQNHVLEVKDLSIYYGNKQAVHHVNMD IEKNAVTALIGPSGCGKSTFLRNINRMNDLIPSARAEGEILYEGLNILGGNINVVSLR REIGMVFQKPNPFPKSIYANITHALKYAGERNKAVLDEIVEESLTKAALWDEVKDRLH SSALSLSGGQQQRLCIARTLAMKPAVLLLDEPASALDPISNAKIEELITGLKREYSII IVTHNMQQALRVSDRTAFFLNGELVEYGQTEQIFTSPKKQKTEDYINGKFG*" gene complement(2443601..2444410) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" CDS complement(2444431..2445315) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390376.2" /db_xref="EnsemblGenomes-Gn:BSU24970" /db_xref="EnsemblGenomes-Tr:CAB14427" /db_xref="GOA:P46340" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR005672" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11377" /db_xref="UniProtKB/Swiss-Prot:P46340" /translation="MNRKITDKLATGMFGLCAAIIAAILVGLFSYIIINGVSQLSFQF ITTKSSAIAAGGGIRDQLFNSFYILFITMLITIPLGVGGGVFMAEYAPNNKVTDFIRT CIEVLSSLPSIVIGMFGLLMFVNLTGWGYTIIGGALALTVFNLPVMVRVTEDAIRSVP KDLKEASLALGVSRWHTVKTVLIPSAIPSIITGAILASGRVFGEAAALLFTAGLTTPR LNFTEWNPFSETSPLNIFRPAETLAVHIWNVNTQGMIPDAEAIANGGSAVLVISVLVF NLAARWLGTMIYKKLTAN*" gene complement(2444431..2445315) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" CDS complement(2445315..2446244) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390377.2" /db_xref="EnsemblGenomes-Gn:BSU24980" /db_xref="EnsemblGenomes-Tr:CAB14428" /db_xref="GOA:P46339" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011864" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11376" /db_xref="UniProtKB/Swiss-Prot:P46339" /translation="MINNRENMSVSERLISSRQNRQLDEVRGRMIVTACALIMIAASV AITIFLGVKGLQSFLVNGVSPIEFLTSLNWNPTDSDPKYGVLPFIFGSFAVTILSALI AAPLGIAGAIFMTEIAPNWGKKVLQPVIELLVGIPSVVYGFIGLTVLVPFIAQFKSSG TGHSLLAGTIVLSVMILPTITSISADAMASLPKSLREGSYALGATRWQTIRKVLVPAA FPTLMTAVVLGMARAFGEALAVQMVIGNTRVLPESPFDTAGTLTTIITLNMGHTTYGS VENNTLWSMGLVLLVMSFLFILLIRYLSSRRKV*" gene complement(2445315..2446244) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" CDS complement(2446313..2447215) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 9593301, 10913081, 15289558, 21461370, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 9593301, 10913081, 15289558, 21461370, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (phosphate binding lipoprotein)" /protein_id="NP_390378.1" /db_xref="EnsemblGenomes-Gn:BSU24990" /db_xref="EnsemblGenomes-Tr:CAB14429" /db_xref="GOA:P46338" /db_xref="InterPro:IPR011862" /db_xref="InterPro:IPR024370" /db_xref="SubtiList:BG11375" /db_xref="UniProtKB/Swiss-Prot:P46338" /translation="MKKNKLVLMLLMAAFMMIAAACGNAGESKKSNSDSAKGEEKASG SLTISGSSAMQPLVLAAAEKFMEENPDADIQVQAGGSGTGLSQVSEGAVQIGNSDVFA EEKEGIDAKALVDHQVAVVGMAAAVNPDAGVKDISKDELKKIFTGKIKNWKELGGKDQ KITLVNRPDSSGTRATFVKYALDGAEPAEGITEDSSNTVKKIIADTPGAIGYLAFSYL TDDKVTALSIDGVKPEAKNVATGEYPIWAYQHSYTKGEATGLAKEFLDYLKSEDIQKS IVTDQGYIPVTDMKVTRDANGKQS*" gene complement(2446313..2447215) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" upshifts complement(2447270) /Source="Nicolas_upshifts" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" promotor_-10 complement(2447278..2447294) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2447305..2447307) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2447369..2449519) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" /EC_number="3.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9139922, 9851991, 12896990, 17307860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139922, 9851991, 12896990, 17307860; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transpeptidase (penicillin-binding protein 2A)" /protein_id="NP_390379.1" /db_xref="EnsemblGenomes-Gn:BSU25000" /db_xref="EnsemblGenomes-Tr:CAB14430" /db_xref="GOA:P54488" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11678" /db_xref="UniProtKB/Swiss-Prot:P54488" /translation="MRRNKPKKQNHKEKKKSLPIRLNILFLAAFVIFTWIIVELGIKQ IVQGDDYKNQANKQEQSEVSSAVPRGKIYDRNFNAIVTNKALNAITYTRSKSTTQEQR LKIAKKLSDMIKVDTKKVTERDKKDYWILTRPKEAKKLISSKERQQVEDKKISDDDLY QLQLKRITDKQLNELTDKDMQILAIKRQMDSGYALTPQYIKNEDVSAKEMAVVSEHLD ELPGVDVTSDWEREYPYKNLLRSVLGSVSSSNEGLPSNLLDHYLSLGYSRNDRVGKSY LEYQYESLLQGQKAKVENITDSKGNVTGTKTVSEGKAGKDLVLTIDIDLQKSVEKIIE KKLKAAKARPSTELLDRAFVVMMDPRNGEVLTMAGKQIKRENGAYKFDDYALGAMTSS YAMGSAVKGATVLTGLQTGAINLNTVFKDEPLYIGQDKRGKKSWQNLGPVGIQTALEK SSNVFMFKTAIAVGKGEYKPHQALPLDTSAFDTFRNYFSQFGLGVKTGIDLPNEMTGY KGTSRLSGFLLDFAIGQYDTYTPLELAQYVSTIANGGYRMKPQLVKEVRDSNAKKGIG AVVDSVQPEVLNKVDMKSSYIEEVQAGFRRVATKGTAAGQLASASYKPAAKTGTAQSF YDGPDKSKTGTDTYNTTLVAYAPADNPEIAISVVVPWTYIDYNQRYSITNEIGREVMD KYFELKSKQDKEGTQQKNKDKIEENAENTTSSDN*" gene complement(2447369..2449519) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" downshifts complement(2447379) /Source="Nicolas_upshifts" /id="D1295" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="1.22121" /MaxDrop="8.82988" /score="31.2726004" /energy="-10" /TU="U1940" /idTUdmin="U1938" /TUdmin="-6" /isTUend="TRUE" promotor_-10 complement(2448113..2448131) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2448121) /Source="Nicolas_upshifts" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2448147..2448153) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2448808..2448827) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2448825) /Source="Nicolas_upshifts" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2448841..2448850) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2449569..2449588) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2449574) /Source="Nicolas_upshifts" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" promotor_-35 complement(2449604..2449608) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2449633..2450925) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390380.2" /db_xref="EnsemblGenomes-Gn:BSU25010" /db_xref="EnsemblGenomes-Tr:CAB14431" /db_xref="GOA:P54487" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11677" /db_xref="UniProtKB/Swiss-Prot:P54487" /translation="MSKLKKVIGDVDVNKGLLFLLTIGGLYSLGIALSNTFVNVYLWK QSGKFIDLAIYNLSIVTMQPITFYLAGRLAKKIDRVFILRFGVIFLAAFYLSVLLAGE TAASRLVLIGAVLGVGYGFYWLAFNVLTFEITEPDTRDFFNGFMGILSSSAGMIGPIV AGFVISRLENNTGYTVIFSLSLSLFALAVVMSFFLKRRESKGRFMLSKVFGERHSNMN WRRITNAHFFQGLREGIFVFLISVFVFIETNSELALGTFGLVNSAVSFFAYYFASRLI KKKARKKSILLGGLILYGALFLILFHMSFSTLLTYGVFIAIGYPLLLVPYVSLTYDVI GRARHARKARIEYIVLREMFLNAGRIVSILCFLLIVALLKEDVGIPLSLAILGIGHPL IYYFVKDIRFKEKEGENETMEEDGQKRVTEPTLLKGER*" gene complement(2449633..2450925) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" promotor_-10 complement(2450948..2450959) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2450959) /Source="Nicolas_upshifts" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" promotor_-35 complement(2450973..2450979) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2451032..2451640) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" /EC_number="1.15.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Mn[2+]-dependent)" /protein_id="NP_390381.3" /db_xref="EnsemblGenomes-Gn:BSU25020" /db_xref="EnsemblGenomes-Tr:CAB14432" /db_xref="GOA:P54375" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="PDB:2RCV" /db_xref="SubtiList:BG11676" /db_xref="UniProtKB/Swiss-Prot:P54375" /translation="MAYELPELPYAYDALEPHIDKETMTIHHTKHHNTYVTNLNKAVE GNTALANKSVEELVADLDSVPENIRTAVRNNGGGHANHKLFWTLLSPNGGGEPTGALA EEINSVFGSFDKFKEQFAAAAAGRFGSGWAWLVVNNGKLEITSTPNQDSPLSEGKTPI LGLDVWEHAYYLNYQNRRPDYISAFWNVVNWDEVARLYSEAK*" gene complement(2451032..2451640) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" downshifts complement(2451047) /Source="Nicolas_upshifts" /id="D1296" /incds=0 /nref=265 /ntot=268 /MaxReadThrough="4.329" /MaxDrop="9.16338" /score="3.26408916" /energy="-8.1" /TU="U1943" /idTUdmin="U1942" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2451692..2451711) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2451703) /Source="Nicolas_upshifts" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" S_feature complement(2451705..2451773) /Source="Nicolas_S_feature" /locus_tag="new_2586107_2586175_c" /HighExp="Etha, Salt, Heat, LPhT, Gly, Sw, S4, LoTm, M9-stat, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigB" /TUlongPSig="0.999" /label="S936" promotor_-35 complement(2451726..2451733) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2451764..2451782) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2451773) /Source="Nicolas_upshifts" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" promotor_-35 complement(2451797..2451803) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2451819..2452301) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390382.1" /db_xref="EnsemblGenomes-Gn:BSU25030" /db_xref="EnsemblGenomes-Tr:CAB14433" /db_xref="GOA:P54486" /db_xref="InterPro:IPR007403" /db_xref="SubtiList:BG11675" /db_xref="UniProtKB/Swiss-Prot:P54486" /translation="MDMLYWLLIAAVFIIAFIGLVYPVIPSVVFIVAGFVLYGFLFSF SPYSYMFWLVEAVFAAVLFAADYVSNLLGVKRFGGSKAAIWGSTIGLLIGPFVIPVAG IILGPFIGAVCAELIVHQKDLKSAFKIGLGSLIGFLTGVIAKGIIQLLMIGYFLWTVL *" gene complement(2451819..2452301) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" S_feature complement(2452302..2452594) /Source="Nicolas_S_feature" /locus_tag="new_2586704_2586996_c" /HighExp="Etha, Gly, Salt, aero, S0, LoTm, HiTm, LPh, nit, ferm" /AntisenseName="yqgB" /AntisenseCor="9.8584854910492598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S937" promotor_-35 2452344..2452350 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2452365..2452384 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2452378 /Source="Nicolas_upshifts" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" CDS 2452411..2453178 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15294815; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390383.2" /db_xref="EnsemblGenomes-Gn:BSU25040" /db_xref="EnsemblGenomes-Tr:CAB14434" /db_xref="GOA:P54485" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG11674" /db_xref="UniProtKB/Swiss-Prot:P54485" /translation="MNVFQLFIKSTYSPRDIAKTRFQGIGKAILYVFLLSVLFAIPTA YYVSTGTVKSMNGFKTVLNKDFPDFTISNGKLQTDEKKATESQANGFVIVFDPTDSYG TEQIEAKQNAIGILQNKFVLAIDGQAQEMSYSMMPSELQKKDVIAGLNQNKAMIVTVL SALIFLVTAAGKFIEVSFLALIGLIIKNSQKKHLSYHQLWKLSAYSITLSTVFFTIMR ALEATVPSEFLLNWFVNFVILFLVLKEIPSKKVINKS*" gene 2452411..2453178 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" promotor_-10 complement(2452592..2452610) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-10" upshifts complement(2452594) /Source="Nicolas_upshifts" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" S_feature complement(2452596..2453532) /Source="Nicolas_S_feature" /locus_tag="new_2586998_2587934_c" /HighExp="S0, S1, aero, M0t45, HPh, Lbtran, LPh, GM 120, nit, M/G" /AntisenseName="yqgB" /AntisenseCor="0.31978785018705103" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S938" promotor_-35 complement(2452624..2452630) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-35" S_feature 2453179..2453609 /Source="Nicolas_S_feature" /locus_tag="new_2587581_2588011" /HighExp="C30, HiOs, UNK1, Gly, Fru, S8, Salt, MG 5, S7, MG 25" /AntisenseName="yqgA" /AntisenseCor="0.170248276038857" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.731" /TUlongSig="NA" /TUlongPSig="NA" /label="S939" downshifts 2453566 /Source="Nicolas_upshifts" /id="D1297" /incds=0 /nref=5 /ntot=131 /MaxReadThrough="3.89102" /MaxDrop="3.29021" /score="30.8580926" /energy="-13.8" /TU="U1944" /idTUdmin="U1944" /TUdmin="-88" /isTUend="FALSE" downshifts complement(2453577) /Source="Nicolas_upshifts" /id="D1298" /incds=0 /nref=15 /ntot=207 /MaxReadThrough="6.7306" /MaxDrop="3.9194" /score="7.48192829" /energy="-14.3" /TU="U1947" /idTUdmin="U1945" /TUdmin="-1848" /isTUend="FALSE" CDS complement(2453594..2454022) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" /experiment="publication(s) with functional evidences, PMID:25130749, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25130749, 27797724; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="cell wall protein" /protein_id="NP_390384.2" /db_xref="EnsemblGenomes-Gn:BSU25050" /db_xref="EnsemblGenomes-Tr:CAB14435" /db_xref="GOA:P54484" /db_xref="SubtiList:BG11673" /db_xref="UniProtKB/Swiss-Prot:P54484" /translation="MKQGKFSVFLILLLMLTLVVAPKEKAEAASSGWQPVSGISGCKI RVITDAYTYTKSATSIDAYAETNGKCGKLNYKSFGVSIVEGGDIGPQYSGYFSSRTPT KKFYFSKLPKPTGTPWAVGLSVYKGKAKGAAFVYINPQKR*" gene complement(2453594..2454022) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" promotor_-35 2454018..2454022 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-35" promotor_-10 2454032..2454046 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-10" upshifts 2454041 /Source="Nicolas_upshifts" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" promotor_-10 complement(2454045..2454064) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-10" upshifts complement(2454068) /Source="Nicolas_upshifts" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" promotor_-35 complement(2454079..2454086) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-35" promotor_-35 2454237..2454242 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2454258..2454276 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2454270 /Source="Nicolas_upshifts" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" CDS 2454299..2454598 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15294815; Product type ph : phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390385.1" /db_xref="EnsemblGenomes-Gn:BSU25060" /db_xref="EnsemblGenomes-Tr:CAB14436" /db_xref="GOA:P54483" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR020506" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11672" /db_xref="UniProtKB/Swiss-Prot:P54483" /translation="MKRLTLVCSIVFILFILFYDLKIGTIPIQDLPVYEASAKTAVQE PAYKTVKVKPGDTVMSIVGSAGSPDDIVKDFEALNPNVKANAIQAGTAYKFPVYP*" gene 2454299..2454598 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" promotor_-35 2454611..2454618 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2454633..2454652 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2454644..2454720 /Source="Nicolas_S_feature" /locus_tag="new_2589046_2589122" /HighExp="Diami, dia5, dia15, H2O2, Etha, Salt, LBGexp, Oxctl, Paraq, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.999, 1" /TUlongSig="Sig-" /TUlongPSig=0 /label="S940" upshifts 2454644 /Source="Nicolas_upshifts" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" CDS 2454721..2455854 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" /EC_number="1.17.7.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12571359, 16268586, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase)" /protein_id="NP_390386.1" /db_xref="EnsemblGenomes-Gn:BSU25070" /db_xref="EnsemblGenomes-Tr:CAB14437" /db_xref="GOA:P54482" /db_xref="InterPro:IPR004588" /db_xref="InterPro:IPR011005" /db_xref="InterPro:IPR016425" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11671" /db_xref="UniProtKB/Swiss-Prot:P54482" /translation="MQVSEITHRTKTRPVKVGPLTIGGNNEVVIQSMTTTKTHDVEAT VAEINRLAEAGCQIVRVACPDERAANAIADIKKRISIPLVVDIHFDYKLALKAIEGGA DKIRINPGNIGRREKVEAVVKAAKDKGIPIRIGVNAGSLEKRILEKYGYPTADGMVES ALHHIKILEDLDFHDIIVSMKASDVNLAIEAYEKAAKAFDYPLHLGITESGTLFAGTV KSAAGLGAILSKGIGNTMRISLSADPVEEVKVARELLKSFGLASNAATLISCPTCGRI EIDLISIANEVEEYISKIKAPIKVAVLGCAVNGPGEAREADIGIAGARGEGLLFRKGK IVRKVPEETMVEELKKEIDILAEEHYAKLEAEKAKLKEETQKA*" gene 2454721..2455854 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" downshifts 2455835 /Source="Nicolas_upshifts" /id="D1299" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.62035" /MaxDrop="8.92434" /score="30.8580926" /energy="-13.8" /TU="NA" /idTUdmin="U1948" /TUdmin=3 /isTUend="TRUE" CDS complement(2455880..2456269) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function expressed in germinating spores" /protein_id="NP_390387.1" /db_xref="EnsemblGenomes-Gn:BSU25080" /db_xref="EnsemblGenomes-Tr:CAB14438" /db_xref="GOA:P54481" /db_xref="SubtiList:BG11670" /db_xref="UniProtKB/Swiss-Prot:P54481" /translation="MKVANDYEKRDNNSYYVDHGSEGTNITRDNDGFFEETAAEIAEP YRAADRSNDQDNDRSGGNVNEGRGIGYIALALSIISLFVLPVLLGAAGIIVGYIARRR GAQGLGAWAMGIGVVSLVLGIFIIPFF*" gene complement(2455880..2456269) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" downshifts complement(2455906) /Source="Nicolas_upshifts" /id="D1300" /incds=0 /nref=10 /ntot=62 /MaxReadThrough="1.85077" /MaxDrop="8.74353" /score="28.1764525" /energy="-13.8" /TU="NA" /idTUdmin="U1950" /TUdmin=2 /isTUend="TRUE" promotor_-10 complement(2456300..2456311) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2456304) /Source="Nicolas_upshifts" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" promotor_-35 complement(2456325..2456331) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2456344..2456351 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2456362..2456381 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2456363 /Source="Nicolas_upshifts" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" CDS 2456402..2456983 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotidase" /protein_id="NP_390388.1" /db_xref="EnsemblGenomes-Gn:BSU25090" /db_xref="EnsemblGenomes-Tr:CAB14439" /db_xref="GOA:P54480" /db_xref="InterPro:IPR009206" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11669" /db_xref="UniProtKB/Swiss-Prot:P54480" /translation="MLRLGIDIDGTITAQDTFVPYLNRSFNLSISLNDMTDYDLTKLL NITQEEFWDWMNQNEAIIYKEALLAQHAKQSLDLLKEEHKLIYITARRTHLTDITYEW FDRQNIHYDHIELVGGHHKVEAVKNHNIDLFFEDHHGNAMMIAKEAGIPVILFNSPYN QLPIDSNIIRVNNWLEAVQWMNNNKHHLIRVNN*" gene 2456402..2456983 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" downshifts 2456981 /Source="Nicolas_upshifts" /id="D1301" /incds=0 /nref=34 /ntot=240 /MaxReadThrough="4.07255" /MaxDrop="4.44714" /score="-2.90660182" /energy="-8" /TU="U1951" /idTUdmin="U1951" /TUdmin="-611" /isTUend="FALSE" S_feature 2457026..2457634 /Source="Nicolas_S_feature" /locus_tag="new_2591428_2592036" /HighExp="LoTm, S8, Cold, S7, S5, Sw, BC, S6, HiOs, B60" /AntisenseName="zur" /AntisenseCor="-0.265512398914523" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S941" CDS complement(2457026..2457463) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Zn[2+]-binding Fur family)" /protein_id="NP_390389.2" /db_xref="EnsemblGenomes-Gn:BSU25100" /db_xref="EnsemblGenomes-Tr:CAB14440" /db_xref="GOA:P54479" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11668" /db_xref="UniProtKB/Swiss-Prot:P54479" /translation="MNVQEALNLLKENGYKYTNKREDMLQLFADSDRYLTAKNVLSAL NDDYPGLSFDTIYRNLSLYEELGILETTELSGEKLFRFKCSFTHHHHHFICLACGKTK EIESCPMDKLCDDLDGYQVSGHKFEIYGTCPDCTAENQENTTA*" gene complement(2457026..2457463) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" downshifts complement(2457030) /Source="Nicolas_upshifts" /id="D1302" /incds=0 /nref=181 /ntot=243 /MaxReadThrough="2.37371" /MaxDrop="6.74703" /score="16.4418277" /energy="-11.9" /TU="U1956" /idTUdmin="U1952" /TUdmin=0 /isTUend="TRUE" S_feature complement(2457464..2457558) /Source="Nicolas_S_feature" /locus_tag="new_2591866_2591960_c" /HighExp="LPhT, G180, Cold, LBGstat, H2O2, Oxctl, G135, G150, HPh, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S942" promotor_-10 complement(2457554..2457573) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2457558) /Source="Nicolas_upshifts" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" promotor_-35 complement(2457588..2457595) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2457601..2458482) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390390.2" /db_xref="EnsemblGenomes-Gn:BSU25110" /db_xref="EnsemblGenomes-Tr:CAB14441" /db_xref="GOA:P54478" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11667" /db_xref="UniProtKB/Swiss-Prot:P54478" /translation="MTPTKQHKKETFTHFIFRVFMILVGAASAAVSIELFLIPNDFID GGIIGVSLILDHLFMSNPFLNFAFFVVILNIPFMIFGYKYIGKTFLVSTFIGIVGLAV IESSLHHVEAITTQPILATVFGGLLLGFGVGLVIRNGGSMDGTEILGILLTKKLPFSV GEFVMFINVFIFIWAVFVFGPEQAMYSFMTYYIAMKTIDAVIQGLDETKAVIIVSEQY DEISDAILHRLGRGTTKLKGKGGYTDEEKDVIYAVVTRLEVTKLKSIVFEVDQNAFIT IMNTHETRGGKFKNAIH*" gene complement(2457601..2458482) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" promotor_-35 2458478..2458483 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2458499..2458517 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2458515 /Source="Nicolas_upshifts" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" misc_feature complement(2458520..2458539) /Source="Nicolas_upshift_promotors" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2458526) /Source="Nicolas_upshifts" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" S_feature complement(2458528..2458855) /Source="Nicolas_S_feature" /locus_tag="new_2592930_2593257_c" /HighExp="Cold, T-4.40H, T-5.40H, Salt, GM-0.1, BMM, UNK1, MG 25, GM-0.2, SMM" /AntisenseName="yqfT" /AntisenseCor="-0.62379514374156597" /AntisenseRegPval="-29.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S943" promotor_-35 2458544..2458553 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2458560 /Source="Nicolas_upshifts" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" promotor_-10 2458566..2458585 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2458598..2458852 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390391.1" /db_xref="EnsemblGenomes-Gn:BSU25120" /db_xref="EnsemblGenomes-Tr:CAB14442" /db_xref="InterPro:IPR020277" /db_xref="SubtiList:BG11666" /db_xref="UniProtKB/Swiss-Prot:P54477" /translation="MILFQRIILQRLNQATADDLLKYSKQYGISLTRSQAVEVANLLY GKNVNIFNESERMRLLKQVETITSKETAQTVNELFKQFTS*" gene 2458598..2458852 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" downshifts 2458839 /Source="Nicolas_upshifts" /id="D1303" /incds=0 /nref=12 /ntot=72 /MaxReadThrough="3.97414" /MaxDrop="7.03976" /score="24.5413663" /energy="-9.8" /TU="U1953" /idTUdmin="U1955" /TUdmin="-7" /isTUend="TRUE" CDS complement(2458879..2459772) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" /EC_number="3.1.21.2" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type IV apurinic/apyrimidinic endonuclease" /protein_id="NP_390392.1" /db_xref="EnsemblGenomes-Gn:BSU25130" /db_xref="EnsemblGenomes-Tr:CAB14443" /db_xref="GOA:P54476" /db_xref="InterPro:IPR001719" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR018246" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11665" /db_xref="UniProtKB/Swiss-Prot:P54476" /translation="MLRIGSHVSMSGKHMLLAASQEAVSYGANTFMIYTGAPQNTRRK KIEDLNIEAGRAHMQENGIDEIIVHAPYIINIGNTTNPSTFELGVDFLRSEIERTAAI GAKQIVLHPGAHVGAGAEAGIKKIIEGLNEVIDPNQNVQIALETMAGKGSECGRSFEE LAQIIEGVTHNEQLSVCFDTCHTHDAGYNIVEDFDGVLNEFDKIIGIDRIKVLHINDS KNVKGARKDRHENIGFGEIGFDALQYVVHHEQLKDIPKILETPYVGEDKKNKKPPYRF EIEMLKEKQFDDTLLEKILQQ*" gene complement(2458879..2459772) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" S_feature 2458884..2459685 /Source="Nicolas_S_feature" /locus_tag="new_2593286_2594087" /HighExp="S6, S7, C30, S8, S5, G135, C90, Gly, LoTm, Sw" /AntisenseName="nfo" /AntisenseCor="-0.36683479556464399" /AntisenseRegPval="-9.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S944" downshifts complement(2458900) /Source="Nicolas_upshifts" /id="D1304" /incds=0 /nref=46 /ntot=187 /MaxReadThrough="4.82641" /MaxDrop="6.05328" /score="16.7756411" /energy="-9.8" /TU="U1956" /idTUdmin="U1952" /TUdmin="-1870" /isTUend="FALSE" CDS complement(2459782..2461098) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 16352840, 18203828, 20572937, 23175651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16352840, 18203828, 20572937, 23175651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_390393.1" /db_xref="EnsemblGenomes-Gn:BSU25140" /db_xref="EnsemblGenomes-Tr:CAB14444" /db_xref="GOA:P54475" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030881" /db_xref="SubtiList:BG11664" /db_xref="UniProtKB/Swiss-Prot:P54475" /translation="MKETKFELYELKPFIIDAVHRLGFYEPTDIQKRLIPAVLKKESV IGQSQTGTGKTHAYLLPLLNKIDPAKDVVQVVITAPTRELANQIYQEALKITQGEEGS QIRSKCFIGGTDKQKSIDKLKIQPHLVVGTPGRIADLIKEQALSVHKAESLVIDEADL MLDMGFLADVDYIGSRMPEDLQMLVFSATIPEKLKPFLKKYMENPKYAHVEPKQVTAA KIEHILIPSKHRDKDKLLFDIMSHLNPYLGIVFANTKNTADHIAQYLTGKGMKIGLLH GGLTPRERKKVMKQINDLEFTYIIATDLAARGIDIKGVSHVINYELPDDLDFYVHRVG RTARAGSSGQAMTIYELTDEDALVRLEKMGIEFEYLELEKGEWKKGDDRQRRKKRKKT PNEADEIAHRLVKKPKKVKPGYKKKMSYEMEKIKKKQRRNQSKKRK*" gene complement(2459782..2461098) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" promotor_-10 complement(2461134..2461153) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2461145) /Source="Nicolas_upshifts" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" promotor_-35 complement(2461169..2461173) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2461202..2461211 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2461223 /Source="Nicolas_upshifts" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" promotor_-10 2461225..2461244 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2461267..2462010 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390394.1" /db_xref="EnsemblGenomes-Gn:BSU25150" /db_xref="EnsemblGenomes-Tr:CAB14445" /db_xref="InterPro:IPR025571" /db_xref="SubtiList:BG11663" /db_xref="UniProtKB/Swiss-Prot:P54474" /translation="MFSPQQPMRNYPQPGPPRPMPNQRMMGRRPPNMRGPSFGAQQQG FQQAGQFLPQANAGARNGAGAGGGLKGMLSRFLPGGGGAGSAGVPGIPGAGAAASGGA GLQGIQNIANPASLSSMLGNVQKVLGMAQQVTPMIQQYGPLVRNLPAMMKLYSQLSKS DDTETEANEESEKQSVSEESSEKEKETETKTSDGNKKSKPKSSSLPKKSKTTDNKEQE LKTSAPKKKEAASPAPKRTSGSSKPRLYI*" gene 2461267..2462010 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" downshifts 2461992 /Source="Nicolas_upshifts" /id="D1305" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="5.46594" /MaxDrop="3.2445" /score="4.32537428" /energy="-6.8" /TU="U1957" /idTUdmin="U1957" /TUdmin="-1056" /isTUend="FALSE" promotor_-35 2462014..2462021 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2462035..2462054 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2462037..2462132 /Source="Nicolas_S_feature" /locus_tag="new_2596439_2596534" /HighExp="S8, S7, S6, Cold, H2O2, Salt, dia15, G180, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S945" upshifts 2462037 /Source="Nicolas_upshifts" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" CDS 2462133..2463077 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" /EC_number="1.17.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12706830, 15381396, 15469281, 17458547, 27169371; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase" /protein_id="NP_390395.2" /db_xref="EnsemblGenomes-Gn:BSU25160" /db_xref="EnsemblGenomes-Tr:CAB14446" /db_xref="GOA:P54473" /db_xref="InterPro:IPR003451" /db_xref="SubtiList:BG11662" /db_xref="UniProtKB/Swiss-Prot:P54473" /translation="MDVIKISPRGYCYGVVDAMVIAKNASLDKSLPRPIYILGMIVHN KHVTDAFEEEGIFTLDGSNRLDILKQVDKGTVIFTAHGVSPEVRRIAEEKGLVAIDAT CPDVTKTHNLILEMKEKGYHVIYIGKKGHPEPEGAVGVAPEIVHLVETEEDVKNLDIQ SEKLIVTNQTTMSQWDVHDIMELVKEKYPHVEYHQEICLATQVRQEAVSEQAKKADLT IVVGDPKSNNSNRLAQVSEEIAGTKAYRIGDLSELKLEWLKGVNTVAVTAGASTPTPI TKEVIRFLEQFDHEDPSTWTTEHNIPLKKILPKVKAKN*" gene 2462133..2463077 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" downshifts 2463048 /Source="Nicolas_upshifts" /id="D1306" /incds=0 /nref=106 /ntot=243 /MaxReadThrough="4.04288" /MaxDrop="5.66904" /score="29.529951" /energy="-12.2" /TU="U1958" /idTUdmin="U1957" /TUdmin=0 /isTUend="TRUE" CDS complement(2463100..2464221) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17187687, 17586767; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative GTP cyclohydrolase" /protein_id="NP_390396.1" /db_xref="EnsemblGenomes-Gn:BSU25170" /db_xref="EnsemblGenomes-Tr:CAB14447" /db_xref="GOA:P54472" /db_xref="InterPro:IPR002678" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017221" /db_xref="InterPro:IPR036069" /db_xref="SubtiList:BG11661" /db_xref="UniProtKB/Swiss-Prot:P54472" /translation="MAKSVNGQQIIQLFEQFSPKAYAVEGDKIGLQIGTLNKPIKNVM VTLDVLESVIDEAIEKEVDLIIAHHPPIFRSLKHISTDQPAGRLIEKCLKHDIAVYAA HTNLDVADGGVNDLLAEALELSETEVLAPTYTDPLKKLAVYVPKEYEEQVRAALGNAG AGHIGEYSHCAFSSEGIGSFKPLDGAKPFIGEVGELELVHEVRLETVFPKSVEKAVIN AMIKSHPYEEVAYDIYPVEQTPAEKGLGRVGTLKNEMTLKEFALFVKDKLDVNGVRMV GDADSMVKKVAVLGGDGNKYIHHAKRKGADVYVTGDLYFHVAHDAMMLGLNVVDPGHY AEKIMKEGVTRKLTSMCNDKKFGVNIFVSETDTNPFTFL*" gene complement(2463100..2464221) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" downshifts complement(2463125) /Source="Nicolas_upshifts" /id="D1307" /incds=0 /nref=63 /ntot=224 /MaxReadThrough="3.241" /MaxDrop="4.76436" /score="27.9821938" /energy="-12.2" /TU="NA" /idTUdmin="U1959" /TUdmin="-1" /isTUend="TRUE" CDS complement(2464214..2464864) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" /EC_number="2.1.1.217" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:18420655, 27098549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18420655, 27098549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (adenine(22)-N(1))-methyltransferase" /protein_id="NP_390397.1" /db_xref="EnsemblGenomes-Gn:BSU25180" /db_xref="EnsemblGenomes-Tr:CAB14448" /db_xref="GOA:P54471" /db_xref="InterPro:IPR006901" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11660" /db_xref="UniProtKB/Swiss-Prot:P54471" /translation="MADIGSDHAYLPCYAVLNHKASGAIAGEITDGPFLSAKRQVEKS GLNSHISVRQGDGLEVIKKGEADAITIAGMGGALIAHILEAGKDKLTGKERLILQPNI HAVHIREWLYKERYALIDEVILEEDGKCYEVLVAEAGDRDAAYDGISLSAGMLVGPFL AKEKNAVFLKKWTQELQHTQSIYEQISQAADTEQNKQKLKELADRMELLKEVIDHG*" gene complement(2464214..2464864) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" S_feature complement(2464865..2464973) /Source="Nicolas_S_feature" /locus_tag="new_2599267_2599375_c" /HighExp="LBGexp, LBGtran, dia15, dia0, Lbexp, G150, G180, LBGstat, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S946" promotor_-10 complement(2464961..2464980) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2464973) /Source="Nicolas_upshifts" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" S_feature complement(2464975..2465088) /Source="Nicolas_S_feature" /locus_tag="new_2599377_2599490_c" /HighExp="Lbstat, M0t90, M9-stat, S2, T1.0H, T1.30H, T2.30H, T3.0H, S7, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S947" promotor_-35 complement(2464996..2465000) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2465121..2465483) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10024472, 10473570, 11361075, 15995641, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024472, 10473570, 11361075, 15995641, 19222757; Product type c: carrier" /codon_start=1 /transl_table=11 /product="cytochrome c550" /protein_id="NP_390398.1" /db_xref="EnsemblGenomes-Gn:BSU25190" /db_xref="EnsemblGenomes-Tr:CAB14449" /db_xref="GOA:P24469" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10315" /db_xref="UniProtKB/Swiss-Prot:P24469" /translation="MKWNPLIPFLLIAVLGIGLTFFLSVKGLDDSREIASGGESKSAE KKDANASPEEIYKANCIACHGENYEGVSGPSLKGVGDKKDVAEIKTKIEKGGNGMPSG LVPADKLDDMAEWVSKIK*" gene complement(2465121..2465483) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" downshifts complement(2465133) /Source="Nicolas_upshifts" /id="D1308" /incds=0 /nref=3 /ntot=88 /MaxReadThrough="4.32389" /MaxDrop="3.4795" /score="-4.13120914" /energy="-7.6" /TU="U1961,U1962" /idTUdmin="U1968" /TUdmin="-7" /isTUend="TRUE" promotor_-35 2465479..2465483 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2465491..2465505 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2465512 /Source="Nicolas_upshifts" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2465520..2465539) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2465522) /Source="Nicolas_upshifts" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" S_feature complement(2465524..2465645) /Source="Nicolas_S_feature" /locus_tag="new_2599926_2600047_c" /HighExp="Lbstat, T3.0H, T1.30H, M9-stat, T2.30H, T1.0H, T2.0H, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S948" promotor_-35 complement(2465551..2465558) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2465625 /Source="Nicolas_upshift_promotors" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2465634..2465653) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2465642..2465661 /Source="Nicolas_upshift_promotors" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2465645) /Source="Nicolas_upshifts" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" S_feature complement(2465647..2465786) /Source="Nicolas_S_feature" /locus_tag="new_2600049_2600188_c" /HighExp="Lbstat, S8, S1, S7, G/S, BT, Mal, Gly, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S949" S_feature 2465648..2465752 /Source="Nicolas_S_feature" /locus_tag="new_2600050_2600154" /HighExp="T2.30H, M9-stat, T3.0H, T1.30H, T2.0H, T1.0H, T3.30H, T4.0H, M0t90, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S950" upshifts 2465648 /Source="Nicolas_upshifts" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" promotor_-35 complement(2465667..2465673) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2465716..2465723 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2465737..2465756 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2465754..2467903 /Source="Nicolas_S_feature" /locus_tag="new_2600156_2602305" /HighExp="S2, T4.0H, T5.0H, Lbstat, M9-stat, T3.30H, S8, T3.0H, C30, T2.0H" /AntisenseName="sigA" /AntisenseCor="-0.16938350693676901" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S951" upshifts 2465754 /Source="Nicolas_upshifts" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" CDS complement(2465812..2466927) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12455702, 12682299, 14527287, 15060039, 15670950, 28648455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12455702, 12682299, 14527287, 15060039, 15670950, 28648455; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase major sigma-43 factor (sigma-A)" /protein_id="NP_390399.2" /db_xref="EnsemblGenomes-Gn:BSU25200" /db_xref="EnsemblGenomes-Tr:CAB14450" /db_xref="GOA:P06224" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007127" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR009042" /db_xref="InterPro:IPR012760" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR028630" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10314" /db_xref="UniProtKB/Swiss-Prot:P06224" /translation="MADKQTHETELTFDQVKEQLTESGKKRGVLTYEEIAERMSSFEI ESDQMDEYYEFLGEQGVELISENEETEDPNIQQLAKAEEEFDLNDLSVPPGVKINDPV RMYLKEIGRVNLLSAKEEIAYAQKIEEGDEESKRRLAEANLRLVVSIAKRYVGRGMLF LDLIQEGNMGLMKAVEKFDYRKGYKFSTYATWWIRQAITRAIADQARTIRIPVHMVET INKLIRVQRQLLQDLGREPTPEEIAEDMDLTPEKVREILKIAQEPVSLETPIGEEDDS HLGDFIEDQEATSPSDHAAYELLKEQLEDVLDTLTDREENVLRLRFGLDDGRTRTLEE VGKVFGVTRERIRQIEAKALRKLRHPSRSKRLKDFLE*" gene complement(2465812..2466927) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" downshifts complement(2465831) /Source="Nicolas_upshifts" /id="D1309" /incds=0 /nref=118 /ntot=198 /MaxReadThrough="4.93947" /MaxDrop="6.16048" /score="4.75833607" /energy="-11.7" /TU="U1966,U1968,U1969,U1970,U1972,U1973" /idTUdmin="U1970" /TUdmin="-287" /isTUend="FALSE" S_feature complement(2466928..2467125) /Source="Nicolas_S_feature" /locus_tag="new_2601330_2601527_c" /HighExp="BC, Cold, SMMPr, S1, BI, G135, C30, Lbstat, S5, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S952" CDS complement(2467126..2468937) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" /EC_number="2.7.7.-" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3100394, 9387153, 12682299, 16036556, 28386108; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA primase" /protein_id="NP_390400.2" /db_xref="EnsemblGenomes-Gn:BSU25210" /db_xref="EnsemblGenomes-Tr:CAB14451" /db_xref="GOA:P05096" /db_xref="InterPro:IPR002694" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR006295" /db_xref="InterPro:IPR013264" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR019475" /db_xref="InterPro:IPR030846" /db_xref="InterPro:IPR034151" /db_xref="InterPro:IPR036185" /db_xref="InterPro:IPR036977" /db_xref="InterPro:IPR037068" /db_xref="PDB:5GUJ" /db_xref="SubtiList:BG10313" /db_xref="UniProtKB/Swiss-Prot:P05096" /translation="MGNRIPDEIVDQVQKSADIVEVIGDYVQLKKQGRNYFGLCPFHG ESTPSFSVSPDKQIFHCFGCGAGGNVFSFLRQMEGYSFAESVSHLADKYQIDFPDDIT VHSGARPESSGEQKMAEAHELLKKFYHHLLINTKEGQEALDYLLSRGFTKELINEFQI GYALDSWDFITKFLVKRGFSEAQMEKAGLLIRREDGSGYFDRFRNRVMFPIHDHHGAV VAFSGRALGSQQPKYMNSPETPLFHKSKLLYNFYKARLHIRKQERAVLFEGFADVISA VSSDVKESIATMGTSLTDDHVKILRRNVEEIILCYDSDKAGYEATLKASELLQKKGCK VRVAMIPDGLDPDDYIKKFGGEKFKNDIIDASVTVMAFKMQYFRKGKNLSDEGDRLAY IKDVLKEISTLSGSLEQEVYVKQLASEFSLSQESLTEQLSVFSKQNKPADNSGETKTR RAHLTTKARQKRLRPAYENAERLLLAHMLRDRSVIKKVIDRVGFQFNIDEHRALAAYL YAFYEEGAELTPQHLMARVTDDHISQLLSDILMLQVNQELSEAELSDYVKKVLNQRNW SMIKEKEAERAEAERQKDFLRAASLAQEIVTLNRSLK*" gene complement(2467126..2468937) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" promotor_-35 2468532..2468538 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2468548 /Source="Nicolas_upshifts" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" promotor_-10 2468550..2468569 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2468577..2468873 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 9864351" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_054587.1" /db_xref="EnsemblGenomes-Gn:BSU25220" /db_xref="EnsemblGenomes-Tr:CAE01462" /db_xref="GOA:Q7WY63" /db_xref="SubtiList:BG14178" /db_xref="UniProtKB/Swiss-Prot:Q7WY63" /translation="MPQPFFVLQKTLAGLRNGLLYHLENQFGICQQGEKPTRQKNSLP SALKKRKHCRPLRSQSNEKSVCRAIRKTKVCFLHEKDRVQSSFGLASLIEHNHL*" gene 2468577..2468873 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" CDS complement(2468971..2469465) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9387153, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390401.2" /db_xref="EnsemblGenomes-Gn:BSU25230" /db_xref="EnsemblGenomes-Tr:CAB14452" /db_xref="InterPro:IPR003791" /db_xref="SubtiList:BG10312" /db_xref="UniProtKB/Swiss-Prot:P17868" /translation="MEGWRITLLNEQEKTIFVDADACPVKDEILQTASEYEVQVLFVA SFEHYQLSRSNEEKWKYVDPHKEAADLYIANHVKPGDIVVTQDIGLASLLLNRNVSVM SERGRLYKEDTIDFALEGRHFSGKQRRKGVYAKGPKKLNKEDRERFITLLQKILSNDE GILH*" gene complement(2468971..2469465) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" promotor_-10 complement(2469438..2469456) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2469449) /Source="Nicolas_upshifts" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" S_feature complement(2469466..2469579) /Source="Nicolas_S_feature" /locus_tag="new_2603868_2603981_c" /HighExp="S5, S4, S6, S7, S8, S3, Etha, dia15, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S953" promotor_-35 complement(2469468..2469476) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-35 2469474..2469479 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2469495..2469513 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2469510 /Source="Nicolas_upshifts" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2469564..2469582) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2469579) /Source="Nicolas_upshifts" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" S_feature complement(2469581..2469658) /Source="Nicolas_S_feature" /locus_tag="new_2603983_2604060_c" /HighExp="Etha, G180, G135, G150, LBGtran, LBGexp, dia15, H2O2, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S954" promotor_-35 complement(2469598..2469603) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2469624..2469643) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2469658) /Source="Nicolas_upshifts" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" promotor_-35 complement(2469659..2469662) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2469719..2470531) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 20044937" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 20044937; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional ADP-dependent kinase-Pi-dependent pyrophosphorylase / positive regulator of gluconeogenesis" /protein_id="NP_390402.1" /db_xref="EnsemblGenomes-Gn:BSU25240" /db_xref="EnsemblGenomes-Tr:CAB14453" /db_xref="GOA:P54470" /db_xref="InterPro:IPR005177" /db_xref="InterPro:IPR026565" /db_xref="SubtiList:BG11659" /db_xref="UniProtKB/Swiss-Prot:P54470" /translation="MNNRIIYVVSDSVGETAELVVKAALSQFNGSADDTHVRRIPYVE DIGTINEVISLAKADGGIICFTLVVPEIREYLIAEAEKANVLYYDIIGPLIDKMETAY GLTAKYEPGRVRQLDEDYFKKVEAIEFAVKYDDGRDPRGILKADIVLIGVSRTSKTPL SQYLAHKRLKVANVPIVPEVDPPEELFNVDPKKCIGLKISPDKLNHIRKERLKSLGLN DKAIYANINRIKEELEYFEKIVDRIGCQVVDVSNKAVEETANIIHHLKTKNI*" gene complement(2469719..2470531) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" CDS complement(2470557..2471195) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of gluconeogenesis" /protein_id="NP_390403.1" /db_xref="EnsemblGenomes-Gn:BSU25250" /db_xref="EnsemblGenomes-Tr:CAB14454" /db_xref="GOA:O34994" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016842" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3FV6" /db_xref="PDB:3FWR" /db_xref="PDB:3FWS" /db_xref="SubtiList:BG13768" /db_xref="UniProtKB/Swiss-Prot:O34994" /translation="MSTIELNKRQEHILQIVKENGPITGEHIAEKLNLTRATLRPDLA ILTMSGFLEARPRVGYFYTGKTGTQLLADKLKKLQVKDFQSIPVVIHENVSVYDAICT MFLEDVGTLFVVDRDAVLVGVLSRKDLLRASIGQQELTSVPVHIIMTRMPNITVCRRE DYVMDIAKHLIEKQIDALPVIKDTDKGFEVIGRVTKTNMTKILVSLSENEIL*" gene complement(2470557..2471195) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" S_feature complement(2471196..2471327) /Source="Nicolas_S_feature" /locus_tag="new_2605598_2605729_c" /HighExp="G135, dia5, G180, G150, dia15, H2O2, LBGexp, Lbexp, Oxctl, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999, 0.998" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S955" promotor_-10 complement(2471321..2471340) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" CDS complement(2471328..2473367) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (beta subunit)" /protein_id="NP_390404.2" /db_xref="EnsemblGenomes-Gn:BSU25260" /db_xref="EnsemblGenomes-Tr:CAB14455" /db_xref="GOA:P54381" /db_xref="InterPro:IPR006194" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR015944" /db_xref="SubtiList:BG11658" /db_xref="UniProtKB/Swiss-Prot:P54381" /translation="MSKQDLLLEIGLEEMPARFLNESMVQLGDKLTGWLKEKNITHGE VKLFNTPRRLAVFVKDVAEKQDDIKEEAKGPAKKIALDADGNWTKAAIGFSKGQGANV EDLYIKEVKGIEYVFVQKFQAGQETKSLLPELSGLITSLHFPKNMRWGNEDLRYIRPI KWIVALFGQDVIPFSITNVESGRTTQGHRFLGHEVSIESPSAYEEQLKGQHVIADPSV RKQMIQSQLETMAAENNWSIPVDEDLLDEVNHLVEYPTALYGSFESEFLSIPEEVLVT TMKEHQRYFPVKDKNGDLLPHFITVRNGNSHAIENVARGNEKVLRARLSDASFFYKED QKLNIDANVKKLENIVFHEELGSLADKVRRVTSIAEKLAVRLQADEDTLKHVKRAAEI SKFDLVTHMIYEFPELQGIMGEKYARMLGEDEAVAAAVNEHYMPRSAGGETPSTFTGA VVAMADKLDTIASFFSIGVIPTGSQDPYGLRRQASGIVAILLDRNWGISFEELLTFVQ TDKENELLDFFTQRLKYVLNAEQIRHDVIDAVLESSELEPYSALHKAQVLEQKLGAPG FKETAEALGRVISISKKGVRGDIQPDLFENEYEAKLFDAYQTAKQNLQENFSKKDYEA ALASLAALKEPIDAYFDHTMVIADNESLKANRLAQMVSLADEIKSFANMNALIVK*" gene complement(2471328..2473367) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" upshifts complement(2471330) /Source="Nicolas_upshifts" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" promotor_-35 complement(2471355..2471362) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" downshifts complement(2471374) /Source="Nicolas_upshifts" /id="D1310" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="6.14024" /MaxDrop="3.62589" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1320" /isTUend="FALSE" downshifts complement(2471440) /Source="Nicolas_upshifts" /id="D1311" /incds=1 /nref=10 /ntot=162 /MaxReadThrough="6.17154" /MaxDrop="3.30313" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1386" /isTUend="FALSE" CDS complement(2473360..2474247) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390405.1" /db_xref="EnsemblGenomes-Gn:BSU25270" /db_xref="EnsemblGenomes-Tr:CAB14456" /db_xref="GOA:P54380" /db_xref="InterPro:IPR002310" /db_xref="InterPro:IPR006194" /db_xref="SubtiList:BG11657" /db_xref="UniProtKB/Swiss-Prot:P54380" /translation="MNIQDMILTLQKHWSSQGCVLMQAYDVEKGAGTMSPYTFLRSIG PEPWKVAYVEPSRRPADGRYGENPNRLYQHHQFQVIIKPSPDNIQELYLDSLRALGID PLEHDIRFVEDNWENPSLGCAGLGWEVWLDGMEITQFTYFQQVGGLECKPVSVEITYG IERLASYIQDKENVFDLEWTSGFTVKDLFMMAEYEHSVYTFETSDVDMLFQLFSTYEK EAIKQMDNGLVHPAYDYVLKCSHTFNLLDAKGAISVTERTGYIARVRNLARKVAKTYY EEREKLGFPMLKGEGSSHE*" gene complement(2473360..2474247) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" misc_RNA complement(2474330..2474504) /gene="tboG" /locus_tag="BSU_misc_RNA_39" /product="T-box riboswitch controlling synthesis of glycine-tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201, 15890195, 26229106" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201, 15890195, 26229106; Product type n : RNA" gene complement(2474330..2474504) /gene="tboG" /locus_tag="BSU_misc_RNA_39" downshifts complement(2474364) /Source="Nicolas_upshifts" /id="D1312" /incds=0 /nref=70 /ntot=220 /MaxReadThrough="6.60948" /MaxDrop="5.42847" /score="18.9025126" /energy="-23.3" /TU="U1972,U1973,U1975" /idTUdmin="U1976" /TUdmin=178 /isTUend="FALSE" promotor_-35 2474479..2474484 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2474500..2474518 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2474508..2474527) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" S_feature 2474510..2475922 /Source="Nicolas_S_feature" /locus_tag="new_2608912_2610324" /HighExp="C30, S8, Gly, BT, G135, Fru, S6, C90, Lbstat, Mal" /AntisenseName="recO" /AntisenseCor="0.22892689952134901" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S956" upshifts 2474510 /Source="Nicolas_upshifts" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" upshifts complement(2474520) /Source="Nicolas_upshifts" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" promotor_-35 complement(2474542..2474549) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2474544..2475311) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10323239, 15186413, 16061691, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10323239, 15186413, 16061691, 26001966; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA double strand break repair and homologous recombination factor" /protein_id="NP_390406.2" /db_xref="EnsemblGenomes-Gn:BSU25280" /db_xref="EnsemblGenomes-Tr:CAB14457" /db_xref="GOA:P42095" /db_xref="InterPro:IPR003717" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022572" /db_xref="SubtiList:BG11189" /db_xref="UniProtKB/Swiss-Prot:P42095" /translation="MLTKCEGIVLRTNDYGETNKIVTLLTREHGKIGVMARGAKKPNS RLSAVSQPFLYGSFLMQKTSGLGTLQQGEMILSMRGIREDLFLTAYAAYVAELVDRGT EEKKPNPYLFEFILESLKQLNEGTDPDVITFIVQMKMLGVMGLYPELNHCVHCKSQDG TFHFSVRDNGFICHRCFEKDPYRIPIKPQTARLLRLFYYFDLSRLGNVSLKEETKAEL KQVIDLYYEEYSGLYLKSKRFLDQMESMKHLMGENKS*" gene complement(2474544..2475311) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" CDS complement(2475348..2475491) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097761.1" /db_xref="EnsemblGenomes-Gn:BSU25289" /db_xref="EnsemblGenomes-Tr:CAX52661" /db_xref="InterPro:IPR025617" /db_xref="UniProtKB/Swiss-Prot:C0H452" /translation="MLNFTWNVFSQTGNVDTYLLFKELEKENMERPEELEDELARFDY PIL*" gene complement(2475348..2475491) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" S_feature complement(2475492..2475638) /Source="Nicolas_S_feature" /locus_tag="new_2609894_2610040_c" /HighExp="Lbstat, T1.30H, T2.0H, M9-stat, S2, T3.0H, S5, M0t90, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.999, 0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S957" CDS complement(2475639..2476544) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maturation of 16S RNA and assembly of 30S ribosomal subunit GTPase" /protein_id="NP_390407.1" /db_xref="EnsemblGenomes-Gn:BSU25290" /db_xref="EnsemblGenomes-Tr:CAB14458" /db_xref="GOA:P42182" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005662" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030388" /db_xref="SubtiList:BG11188" /db_xref="UniProtKB/Swiss-Prot:P42182" /translation="MTNESFKSGFVSIIGRPNVGKSTFLNRVIGQKIAIMSDKPQTTR NKVQGVLTTGTSQTIFIDTPGIHKPKHKLGDFMMKVAQNTLKEVDLILFMINAEEGYG KGDEFIIEKLQTMSTPVFLIVNKIDKIHPDQLLLLIDEYRKRYPFKEIVPISALEGNN IETLLAQIEAYLPEGPQFYPSDQVTDHPERFIISELIREKVLHLTREEIPHSIAVAIE SIKGQDNGSVHVAATIVVERDSQKGIVIGKKGSLLKEVGKRARADIEALLGSRVYLEL WVKVQKDWRNKMSQLRDFGFKEDEY*" gene complement(2475639..2476544) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" CDS complement(2476525..2476935) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" /EC_number="3.5.4.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2526291, 8157589, 10217788, 11851403, 22720735, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2526291, 8157589, 10217788, 11851403, 22720735, 25890046; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidine/deoxycytidine deaminase" /protein_id="NP_390408.1" /db_xref="EnsemblGenomes-Gn:BSU25300" /db_xref="EnsemblGenomes-Tr:CAB14459" /db_xref="GOA:P19079" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR006262" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1JTK" /db_xref="PDB:1UWZ" /db_xref="PDB:1UX0" /db_xref="PDB:1UX1" /db_xref="SubtiList:BG10477" /db_xref="UniProtKB/Swiss-Prot:P19079" /translation="MNRQELITEALKARDMAYAPYSKFQVGAALLTKDGKVYRGCNIE NAAYSMCNCAERTALFKAVSEGDTEFQMLAVAADTPGPVSPCGACRQVISELCTKDVI VVLTNLQGQIKEMTVEELLPGAFSSEDLHDERKL*" gene complement(2476525..2476935) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" promotor_-10 complement(2476973..2476992) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2476984) /Source="Nicolas_upshifts" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" S_feature complement(2476986..2477053) /Source="Nicolas_S_feature" /locus_tag="new_2611388_2611455_c" /HighExp="Oxctl, H2O2, G180, G150, GM 120, S1, G135, Diami, LBGtran, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S958" promotor_-35 complement(2477007..2477010) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2477054..2477425) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" /EC_number="2.7.1.66" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12923107, 17535816, 19935659, 28872301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenol kinase" /protein_id="NP_390409.2" /db_xref="EnsemblGenomes-Gn:BSU25310" /db_xref="EnsemblGenomes-Tr:CAB14460" /db_xref="GOA:P19638" /db_xref="InterPro:IPR000829" /db_xref="InterPro:IPR033717" /db_xref="InterPro:IPR036945" /db_xref="SubtiList:BG11040" /db_xref="UniProtKB/Swiss-Prot:P19638" /translation="MDSKDHRNELNRFFKSFVHAGRGIWETARTERNFQFHAAAACAV LICGFLVELSIIEWMIIFLLIGGMFSLELLNTAIEHTVDLITDKHHPLAKAAKDAAAG AVCVFAVISCIIGLLIFLPKL*" gene complement(2477054..2477425) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" CDS complement(2477406..2477879) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16511207, 16818608, 19181801, 20639334, 20807199, 23273979, 23638028, 24511998, 24901994, 28031281; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease involved in 70S ribosomes quality control" /protein_id="NP_390410.2" /db_xref="EnsemblGenomes-Gn:BSU25320" /db_xref="EnsemblGenomes-Tr:CAB14461" /db_xref="GOA:P46347" /db_xref="InterPro:IPR002036" /db_xref="InterPro:IPR020549" /db_xref="InterPro:IPR023091" /db_xref="SubtiList:BG11656" /db_xref="UniProtKB/Swiss-Prot:P46347" /translation="MSLLIDIVDETGSVSEEMLKEVENLLQFAAEREGVQDQAEVSVT IVSNDDIHQINKEYRGKDAPTDVISFALEEEGEGEIEIVGAEMPPVLGDIIISADRTR EQAEEYNHSFKRELGFLAVHGFLHLLGYDHMTKEEEEEMFTKQKELLDAYGLKRS*" gene complement(2477406..2477879) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" CDS complement(2477880..2480015) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751502, 26240071, 27378384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751502, 26240071, 27378384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="c-di-AMP-degrading phosphodiesterases" /protein_id="NP_390411.1" /db_xref="EnsemblGenomes-Gn:BSU25330" /db_xref="EnsemblGenomes-Tr:CAB14462" /db_xref="GOA:P46344" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR011621" /db_xref="InterPro:IPR011624" /db_xref="SubtiList:BG11655" /db_xref="UniProtKB/Swiss-Prot:P46344" /translation="MLKKKAKTKSSSKKWSSFKNARSMHVLLYLLLAAIMFALLFVHV KPETLDLDLFSVSDKTIYAPATVEDQKATEEKKQAAEDAVEDQYTLKKEYTDNRIDLV SSIFDSISEVKKSSEEGSKSPSEKSMVKSVKDKLTSDVNDSISEDSIKTLLKADSEDF SFVRDTVITAVNTVMSSEIPSDKLSDAKDKVEKELKSNSIPSKYLGAATEIGRFAIIP NYVFDPKATEAKRQEASDNVQQVQIKQGQVLVEENDLIDREVYRKLELTGLLNNSNLF KPISGLLIMIGLFIATLVYYFEKQKQNLKFKNQSILLFSIITTLLLVIMEVVSLFQKM EYNNIGYLVPIAAGAILIKLLMNERIAILGSIILAICGSMMFNQGVTGTFNYVIGIYY LISGISGVLFLGKHNARSKILQTGLFVAFINMVVVLSLLLIQNTALSGLEIGTLMLMG VVSGFASSVLIIGLMPFFETGFGILSTMRLLELSNPNHPLLRKILTETPGTYHHSVMV ANLSEAACEAVGANGLLARVGAYYHDLGKTKRPQYFIENQMNIDNPHDKLSPQLSKNI IISHTTDGANMLRSYKFPKELVDIAEQHHGTSLLKFFYYKAKEKGDQITEEEFRYPGP KPQSKEAAIISVADSVEAAVRSMHNPNPERIEKLVRGIISDKLQDGQFSECDLTFKEL DTIAKTLCATLKGIFHSRIEYPEATKKVK*" gene complement(2477880..2480015) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" promotor_-35 2479859..2479864 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2479879 /Source="Nicolas_upshifts" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2479880..2479898 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2480094..2481053) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12762842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12762842; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="phosphate starvation-induced protein" /protein_id="NP_390412.2" /db_xref="EnsemblGenomes-Gn:BSU25340" /db_xref="EnsemblGenomes-Tr:CAB14476" /db_xref="GOA:P46343" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11337" /db_xref="UniProtKB/Swiss-Prot:P46343" /translation="MTEHLLAMNQKLKNPDEALSLFGNQDSFLKLMEKDLNLNIITRG ETIYVSGDDESFQIADRLLGSLLALIRKGIEISERDVIYAIKMAKKNELEYFESMYEE EITKNAKGKSIRVKTMGQREYVAAMKRNDLVFGIGPAGTGKTYLAVVKAVHALKNGHI KKIILTRPAVEAGESLGFLPGDLKEKVDPYLRPLYDALHDVLGADHTERLMERGIIEI APLAYMRGRTLDDAYVILDEAQNTTPAQMKMFLTRLGFGSKMIITGDVSQIDLPKGVK SGLAVAKEMLKGIDGISMIELDQTDVVRHPLVAKIIEAYDKQN*" gene complement(2480094..2481053) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" downshifts complement(2480109) /Source="Nicolas_upshifts" /id="D1313" /incds=0 /nref=1 /ntot=63 /MaxReadThrough="6.04676" /MaxDrop="4.50442" /score="9.12152318" /energy="-13.1" /TU="U1975,U1976,U1977" /idTUdmin="U1978" /TUdmin=1034 /isTUend="FALSE" CDS complement(2481050..2482246) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14523133, 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage IV sporulation protein; putative UDP-glucose-4-epimerase" /protein_id="NP_390413.2" /db_xref="EnsemblGenomes-Gn:BSU25350" /db_xref="EnsemblGenomes-Tr:CAB14477" /db_xref="GOA:P54469" /db_xref="InterPro:IPR010690" /db_xref="SubtiList:BG11654" /db_xref="UniProtKB/Swiss-Prot:P54469" /translation="MKNKWLSFFSGKVQLELTGRGIERLLNECTRQGIPVFHVKKKKE AVSLYIQLQDVHAFRRVRSKFKCKARFINRKGFPFLLLKSKLNIGFTIGFAIFFILLF LLSNMVWKIDVTGAKPETEHQMRQHLNEIGVKKGRLQFLMMSPEKIQKSLTNGIDNIT WVGVDLKGTTIHMKVVEKNEPEKEKYVSPRNIVAKKKATITRMFVQKGQPMAAIHDHV EKGQLLVSGLIGSEDHQQEVASKAEIYGETWYRSEVTVPLETLFNVYTGKVRTKHKLS FGSLAIPIWGMTFKKEELKHPKTEQEKHSLHFLGFKLPVSYVKEQTRESEEALRKYTK EEAVQEGIKLGKQDVEDKIGENGEVKSEKVLHQTVENGKVKLIILYQVIEDIVQTTPI VRETEE*" gene complement(2481050..2482246) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" promotor_-10 complement(2481117..2481136) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2481122) /Source="Nicolas_upshifts" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" promotor_-35 complement(2481150..2481157) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2481197..2481215) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-10" upshifts complement(2481209) /Source="Nicolas_upshifts" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" promotor_-35 complement(2481230..2481236) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-35" upshifts complement(2481424) /Source="Nicolas_upshifts" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" promotor_-10 complement(2481438..2481449) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-10" promotor_-35 complement(2481464..2481470) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-35" CDS complement(2482265..2482546) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12662922" /codon_start=1 /transl_table=11 /product="conserved sporulation protein of unknown function" /protein_id="NP_390414.1" /db_xref="EnsemblGenomes-Gn:BSU25360" /db_xref="EnsemblGenomes-Tr:CAB14478" /db_xref="InterPro:IPR022476" /db_xref="InterPro:IPR022477" /db_xref="SubtiList:BG11653" /db_xref="UniProtKB/Swiss-Prot:P54468" /translation="MGQRKNRMKAWLTRALEIPPDVMMDLPRITMVGRLHIYIENHRG LLLFSENEVRLMLKQGQCIISGKNFVIKAILPEEILLEGTIDVVRYVES*" gene complement(2482265..2482546) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" CDS complement(2482603..2483022) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390415.2" /db_xref="EnsemblGenomes-Gn:BSU25370" /db_xref="EnsemblGenomes-Tr:CAB14479" /db_xref="GOA:P54467" /db_xref="InterPro:IPR016788" /db_xref="SubtiList:BG11652" /db_xref="UniProtKB/Swiss-Prot:P54467" /translation="MEDLLTNPLIIAAIIGIISAIFGKKSKEEKQNSQKRKKPQHVQS ASPQKKQSKEDAPAPIPNRMEQARREAEERRRETARNLKGLERDLAAAKQKTVYTKQK MLQVNKDTVVQGIVLGEVFGPPRAKKPHRTMRPARKN*" gene complement(2482603..2483022) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" downshifts complement(2482617) /Source="Nicolas_upshifts" /id="D1314" /incds=0 /nref=232 /ntot=257 /MaxReadThrough="4.55662" /MaxDrop="7.47609" /score="-3.87904232" /energy="-16.8" /TU="U1978" /idTUdmin="U1980" /TUdmin=242 /isTUend="FALSE" CDS complement(2483047..2484042) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12501411, 22753055" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12501411, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="flotillin-like protein involved in membrane lipid rafts" /protein_id="NP_390416.1" /db_xref="EnsemblGenomes-Gn:BSU25380" /db_xref="EnsemblGenomes-Tr:CAB14480" /db_xref="GOA:P54466" /db_xref="InterPro:IPR022853" /db_xref="SubtiList:BG11651" /db_xref="UniProtKB/Swiss-Prot:P54466" /translation="MDPSTLMILAIVAVAIIVLAVFFTFVPVMLWISALAAGVKISIF TLVGMRLRRVIPNRVVNPLIKAHKAGLNVGTNQLESHYLAGGNVDRVVNALIAAQRAN IELTFERCAAIDLAGRDVLEAVQMSVNPKVIETPFIAGVAMDGIEVKAKARITVRANI ERLVGGAGEETIVARVGEGIVSTIGSSDNHKKVLENPDMISQTVLGKGLDSGTAFEIL SIDIADVDIGKNIGAILQTDQAEADKNIAQAKAEERRAMAVAQEQEMRARVEEMRAKV VEAEAEVPLAMAEALREGNIGVMDYMNIKNIDADTEMRDSFGKLTKDPSDEDRKS*" gene complement(2483047..2484042) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" CDS complement(2484064..2485377) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22753055; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound peptidase of unkwnown function" /protein_id="NP_390417.1" /db_xref="EnsemblGenomes-Gn:BSU25390" /db_xref="EnsemblGenomes-Tr:CAB14481" /db_xref="GOA:P54465" /db_xref="InterPro:IPR002810" /db_xref="InterPro:IPR002825" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11650" /db_xref="UniProtKB/Swiss-Prot:P54465" /translation="MLQIKGFRAALLGIFLLSLLGVQLNAKAEKQTVYVIPVEKNVEQ GLASFLSRSLQDAKDAHADHIILDINTPGGLVKSAIDMADLITESEIPVTAYVNKRAL SAGAYIALQADHIYMAPGGKMGAAAIVDGQGNAADQKAQSLWLAEMEDAAVKNNRDPK YALAMADPDIDAKEVGAPKGDLLTLNADKAIEVGYSEGTADNLSTLVKKLGFEKAQIS YAKESFAEKTARWLTNPVIVPILLTIAFLGLTVELFSPGVGLPGTAGLIALLLFFYGH LAAGLAGYETVLLFIAGVILILLEIFLPGGIIGLLGLGAIIASLFLAAGSFTVMAVSL LIASAVSITAFILLTRVLGKRMKFFKKLILNDSTNTESGYVSNQTRTDLMGKVGITFT PLRPSGTVIIDDERLDVVSEGSFTEKDKKVKVIKVEGSRIVVREI*" gene complement(2484064..2485377) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" promotor_-10 complement(2485413..2485428) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-10" upshifts complement(2485430) /Source="Nicolas_upshifts" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" promotor_-35 complement(2485441..2485450) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-35" CDS complement(2485508..2485954) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17284460, 22720735, 25149203" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function with tRNA aminoacid amidase domain" /protein_id="NP_390418.1" /db_xref="EnsemblGenomes-Gn:BSU25400" /db_xref="EnsemblGenomes-Tr:CAB14482" /db_xref="GOA:P54464" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR019004" /db_xref="InterPro:IPR023168" /db_xref="PDB:1NG6" /db_xref="SubtiList:BG11649" /db_xref="UniProtKB/Swiss-Prot:P54464" /translation="MSLLERLNQDMKLYMKNREKDKLTVVRMVKASLQNEAIKLKKDS LTEDEELTVLSRELKQRKDSLQEFSNANRLDLVDKVQKELDILEVYLPEQLSEEELRT IVNETIAEVGASSKADMGKVMGAIMPKVKGKADGSLINKLVSSQLS*" gene complement(2485508..2485954) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" downshifts complement(2485521) /Source="Nicolas_upshifts" /id="D1315" /incds=0 /nref=248 /ntot=267 /MaxReadThrough="5.1355" /MaxDrop="8.31948" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1760 /isTUend="FALSE" downshifts complement(2485719) /Source="Nicolas_upshifts" /id="D1316" /incds=1 /nref=1 /ntot=34 /MaxReadThrough="8.99916" /MaxDrop="1.9798" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1562 /isTUend="FALSE" CDS complement(2485969..2486142) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 22720735, 23002217, 25035996" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 22720735, 23002217, 25035996; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S21" /protein_id="NP_390419.1" /db_xref="EnsemblGenomes-Gn:BSU25410" /db_xref="EnsemblGenomes-Tr:CAB14483" /db_xref="GOA:P21478" /db_xref="InterPro:IPR001911" /db_xref="InterPro:IPR018278" /db_xref="SubtiList:BG11648" /db_xref="UniProtKB/Swiss-Prot:P21478" /translation="MSKTVVRKNESLEDALRRFKRSVSKTGTLQEARKREFYEKPSVK RKKKSEAARKRKF*" gene complement(2485969..2486142) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" misc_feature 2486078..2486082 /Source="Nicolas_upshift_promotors" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2486083 /Source="Nicolas_upshifts" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2486203..2486222) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2486218) /Source="Nicolas_upshifts" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" promotor_-35 complement(2486236..2486243) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2486261..2486266 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2486281 /Source="Nicolas_upshifts" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" promotor_-10 2486282..2486300 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2486315..2487238 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/anion cotransporter" /protein_id="NP_390420.2" /db_xref="EnsemblGenomes-Gn:BSU25420" /db_xref="EnsemblGenomes-Tr:CAB14484" /db_xref="GOA:P54463" /db_xref="InterPro:IPR003841" /db_xref="InterPro:IPR004633" /db_xref="SubtiList:BG11647" /db_xref="UniProtKB/Swiss-Prot:P54463" /translation="MLILISFTALILFFLAGMNMLRKGLISMAYSKIEERLLLFTDHP LKAFLISIVFTGILQSSSAFMVIVIGFVSAGVLSFKRTIPMILGTNVGSTFTTEFIAI KMDIVIWVLLIGGLLFFLTGRYPLKQLGTSFLGLGIIFFCISGFSHLAGPLTKLKTGA DVLYHVNDSNWSALLIGMVLTAIIHSSSVCIGILMSFMNEGIIGLTQAMSVVLGSNIG TCITAVMAAVSGGYAAKQTAYAHVVFNVLGVALVLPFLTAATGFVEQLSPDPAQKIAH FSLLFNVVTALLFLPLTNLFYRLIHLLIPAK*" gene 2486315..2487238 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" CDS complement(2487275..2488630) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA N(6)-threonylcarbamoyladenosine (t(6)A) methylthiotransferase" /protein_id="NP_390421.1" /db_xref="EnsemblGenomes-Gn:BSU25430" /db_xref="EnsemblGenomes-Tr:CAB14485" /db_xref="GOA:P54462" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006467" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR034557" /db_xref="SubtiList:BG11646" /db_xref="UniProtKB/Swiss-Prot:P54462" /translation="MATVAFHTLGCKVNHYETEAIWQLFKEAGYERRDFEQTADVYVI NTCTVTNTGDKKSRQVIRRAIRQNPDGVICVTGCYAQTSPAEIMAIPGVDIVVGTQDR EKMLGYIDQYREERQPINGVSNIMKARVYEELDVPAFTDRTRASLKIQEGCNNFCTFC IIPWARGLLRSRDPEEVIKQAQQLVDAGYKEIVLTGIHTGGYGEDMKDYNFAKLLSEL DTRVEGVKRIRISSIEASQITDEVIEVLDRSDKIVNHLHIPIQSGSNTVLKRMRRKYT MEFFADRLNKLKKALPGLAVTSDVIVGFPGETEEEFMETYNFIKEHKFSELHVFPYSK RTGTPAARMEDQVDENVKNERVHRLIALSDQLAKEYASQYENEVLEIIPEEAFKETEE ENMFVGYTDNYMKVVFKGTEDMIGKIVKVKILKAGYPYNEGQFVRVVEDEITEHMRLS S*" gene complement(2487275..2488630) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" downshifts complement(2487281) /Source="Nicolas_upshifts" /id="D1317" /incds=0 /nref=208 /ntot=260 /MaxReadThrough="1.95578" /MaxDrop="6.05381" /score="30.7201786" /energy="-11.3" /TU="NA" /idTUdmin="U1983" /TUdmin=0 /isTUend="TRUE" CDS complement(2488630..2489400) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" /EC_number="2.1.1.193" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9023197, 10383760, 14517985, 16014871, 16431987, 22925577, 24598751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylase of U1498 in 16S rRNA" /protein_id="NP_390422.1" /db_xref="EnsemblGenomes-Gn:BSU25440" /db_xref="EnsemblGenomes-Tr:CAB14486" /db_xref="GOA:P54461" /db_xref="InterPro:IPR006700" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="PDB:1VHK" /db_xref="SubtiList:BG11645" /db_xref="UniProtKB/Swiss-Prot:P54461" /translation="MQRYFIELTKQQIEEAPTFSITGEEVHHIVNVMRMNEGDQIICC SQDGFEAKCELQSVSKDKVSCLVIEWTNENRELPIKVYIASGLPKGDKLEWIIQKGTE LGAHAFIPFQAARSVVKLDDKKAKKKRERWTKIAKEAAEQSYRNEVPRVMDVHSFQQL LQRMQDFDKCVVAYEESSKQGEISAFSAIVSSLPKGSSLLIVFGPEGGLTEAEVERLT EQDGVTCGLGPRILRTETAPLYALSAISYQTELLRGDQ*" gene complement(2488630..2489400) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" CDS complement(2489423..2490358) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17215866, 18611379; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 methyltransferase" /protein_id="NP_390423.2" /db_xref="EnsemblGenomes-Gn:BSU25450" /db_xref="EnsemblGenomes-Tr:CAB14487" /db_xref="GOA:P54460" /db_xref="InterPro:IPR004498" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11644" /db_xref="UniProtKB/Swiss-Prot:P54460" /translation="MKWSELSIHTTHEAVEPISNILHEAGASGVVIEDPLDLIKEREN VYGEIYQLDPNDYPDEGVIVKAYLPVNSFLGETVDGIKETINNLLLYNIDLGRNHITI SEVNEEEWATAWKKYYHPVKISEKFTIVPTWEEYTPVHTDELIIEMDPGMAFGTGTHP TTVLCIQALERFVQKGDKVIDVGTGSGILSIAAAMLEAESVHAYDLDPVAVESARLNL KLNKVSDIAQVKQNNLLDGIEGEHDVIVANILAEVILRFTSQAYSLLKEGGHFITSGI IGHKKQEVKEALEQAGFTIVEILSMEDWVSIIAKK*" gene complement(2489423..2490358) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" CDS complement(2490383..2491510) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10383760, 10658654, 16385044, 16952052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10383760, 10658654, 16385044, 16952052; Product type f: factor" /codon_start=1 /transl_table=11 /product="co-factor of molecular chaperone" /protein_id="NP_390424.2" /db_xref="EnsemblGenomes-Gn:BSU25460" /db_xref="EnsemblGenomes-Tr:CAB14488" /db_xref="GOA:P17631" /db_xref="InterPro:IPR001305" /db_xref="InterPro:IPR001623" /db_xref="InterPro:IPR002939" /db_xref="InterPro:IPR008971" /db_xref="InterPro:IPR012724" /db_xref="InterPro:IPR018253" /db_xref="InterPro:IPR036410" /db_xref="InterPro:IPR036869" /db_xref="SubtiList:BG10665" /db_xref="UniProtKB/Swiss-Prot:P17631" /translation="MSKRDYYEVLGVSKSASKDEIKKAYRKLSKKYHPDINKEAGSDE KFKEVKEAYETLSDDQKRAHYDQFGHTDPNQGFGGGGFGGGDFGGFGFDDIFSSIFGG GTRRRDPNAPRQGADLQYTMTLSFEDAAFGKETTIEIPREETCETCKGSGAKPGTNPE TCSHCGGSGQLNVEQNTPFGKVVNRRVCHHCEGTGKIIKNKCADCGGKGKIKKRKKIN VTIPAGVDDGQQLRLSGQGEPGINGGPAGDLFVVFHVRAHEFFERDGDDIYCEMPLTF AQAALGDEVEVPTLHGKVKLKIPAGTQTGTKFRLRGKGVQNVRGYGQGDQHIVVRVVT PTNLTDKQKDIIREFAEVSGNLPDEQEMSFFDKVKRAFKGD*" gene complement(2490383..2491510) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" misc_feature 2491427..2491430 /Source="Nicolas_upshift_promotors" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2491438 /Source="Nicolas_upshifts" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2491511..2491688) /Source="Nicolas_S_feature" /locus_tag="new_2625913_2626090_c" /HighExp="Heat, dia15, H2O2, Diami, G135, G150, G180, LPhT, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.357489" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S959" misc_RNA 2491550..2491640 /gene="surC" /locus_tag="BSU_misc_RNA_79" /product="sporulation-related small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" gene 2491550..2491640 /gene="surC" /locus_tag="BSU_misc_RNA_79" CDS complement(2491710..2493545) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular chaperone, ATP-dependent" /protein_id="NP_390425.1" /db_xref="EnsemblGenomes-Gn:BSU25470" /db_xref="EnsemblGenomes-Tr:CAB14489" /db_xref="GOA:P17820" /db_xref="InterPro:IPR012725" /db_xref="InterPro:IPR013126" /db_xref="InterPro:IPR018181" /db_xref="InterPro:IPR029047" /db_xref="InterPro:IPR029048" /db_xref="PDB:2FZO" /db_xref="SubtiList:BG10664" /db_xref="UniProtKB/Swiss-Prot:P17820" /translation="MSKVIGIDLGTTNSCVAVLEGGEPKVIANAEGNRTTPSVVAFKN GERQVGEVAKRQSITNPNTIMSIKRHMGTDYKVEIEGKDYTPQEVSAIILQHLKSYAE SYLGETVSKAVITVPAYFNDAERQATKDAGKIAGLEVERIINEPTAAALAYGLDKTDE DQTILVYDLGGGTFDVSILELGDGVFEVRSTAGDNRLGGDDFDQVIIDHLVSEFKKEN GIDLSKDKMALQRLKDAAEKAKKDLSGVSSTQISLPFITAGEAGPLHLELTLTRAKFE ELSSHLVERTMGPVRQALQDAGLSASEIDKVILVGGSTRIPAVQEAIKKETGKEAHKG VNPDEVVALGAAIQGGVITGDVKDVVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSK SQVFSTAADNQTAVDIHVLQGERPMSADNKTLGRFQLTDIPPAPRGVPQIEVSFDIDK NGIVNVRAKDLGTGKEQNITIKSSSGLSDEEIERMVKEAEENADADAKKKEEIEVRNE ADQLVFQTEKTLKDLEGKVDEEQVKKANDAKDALKAAIEKNEFEEIKAKKDELQTIVQ ELSMKLYEEAAKAQQAQGGANAEGKADDNVVDAEYEEVNDDQNKK*" gene complement(2491710..2493545) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" downshifts complement(2491733) /Source="Nicolas_upshifts" /id="D1318" /incds=0 /nref=130 /ntot=247 /MaxReadThrough="8.0737" /MaxDrop="4.023" /score="21.9400858" /energy="-13.4" /TU="U1983,U1985" /idTUdmin="U1984" /TUdmin=3565 /isTUend="FALSE" CDS complement(2493569..2494132) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nucleotide exchange factor for DnaK activity" /protein_id="NP_390426.1" /db_xref="EnsemblGenomes-Gn:BSU25480" /db_xref="EnsemblGenomes-Tr:CAB14490" /db_xref="GOA:P15874" /db_xref="InterPro:IPR000740" /db_xref="InterPro:IPR009012" /db_xref="InterPro:IPR013805" /db_xref="PDB:2G61" /db_xref="SubtiList:BG10663" /db_xref="UniProtKB/Swiss-Prot:P15874" /translation="MSEEKQTVEQNETEEQEIIEEQAAADEQQEETNESELLQNQINE LQGLLEEKENKLLRVQADFENYKRRSRLEMEASQKYRSQNIVTDLLPALDSFERALQV EADNEQTKSLLQGMEMVHRQLVEALKKEGVEAIEAVGQEFDPNLHQAVMQAEDENYGS NIVVEEMQKGYKLKDRVIRPSMVKVNQ*" gene complement(2493569..2494132) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" S_feature complement(2494133..2494203) /Source="Nicolas_S_feature" /locus_tag="new_2628535_2628605_c" /HighExp="LPhT, dia15, Heat, Etha, Diami, dia5, H2O2, T-0.40H, T0.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S960" CDS complement(2494204..2495235) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10555317, 12082092, 15109714, 16872404, 16585746, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10555317, 12082092, 15109714, 16872404, 16585746, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of heat-shock genes" /protein_id="NP_390427.1" /db_xref="EnsemblGenomes-Gn:BSU25490" /db_xref="EnsemblGenomes-Tr:CAB14491" /db_xref="GOA:P25499" /db_xref="InterPro:IPR002571" /db_xref="InterPro:IPR021153" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10662" /db_xref="UniProtKB/Swiss-Prot:P25499" /translation="MLTNRQLLILQVIINDFIKSAQPVGSRTLSKKDEITFSSATIRN EMADLEELGFIEKTHSSSGRVPSEKGYRYYVDHLLSPVKLTKSDLDQIHSIFKEKIFE LEKTVQKSAQILSDLTNYTSIVLGPKLSENYLKQIQIIPIQPDMAVAILVTNTGHVEN KTINFPTKMDLSDIEKLVNILNDRLSGVPMDELNERIFKEVVMYLRQHIKNYDNILDA LRSTFHSTNHVEKLFFGGKINMLNQPEFHDITRVRSLLSLIEKEQDVLKLVQSPHTGI SIKIGKENDYEEMENCSLITASYSVDQKQIGSIAIIGPTRMNYSRVVSLLQHVTSDLS KALTSLYDE*" gene complement(2494204..2495235) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" promotor_-10 complement(2495276..2495295) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2495289) /Source="Nicolas_upshifts" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" promotor_-35 complement(2495310..2495317) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2495316..2496455) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" /EC_number="1.3.98.3" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8757728, 9371469, 10498703, 12196143, 19944166" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8757728, 9371469, 10498703, 12196143, 19944166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_390428.2" /db_xref="EnsemblGenomes-Gn:BSU25500" /db_xref="EnsemblGenomes-Tr:CAB14492" /db_xref="GOA:P54304" /db_xref="InterPro:IPR004559" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010723" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG11395" /db_xref="UniProtKB/Swiss-Prot:P54304" /translation="MKSAYIHIPFCEHICHYCDFNKYFIQSQPVDEYLNALEQEMINT IAKTGQPDLKTIFIGGGTPTSLSEEQLKKLMDMINRVLKPSSDLSEFAVEANPDDLSA EKLKILKEAGVNRLSFGVQTFEDDLLEKIGRVHKQKDVFTSFERAREIGFENISLDLM FGLPGQTLKHLEHSINTALSLDAEHYSVYSLIVEPKTVFYNLMQKGRLHLPPQEQEAE MYEIVMSKMEAHGIHQYEISNFAKAGMESKHNLTYWSNEQYFGFGAGAHGYIGGTRTV NVGPVKHYIDLIAEKGFPYRDTHEVTTEEQIEEEMFLGLRKTAGVSKKRFAEKYGRSL DGLFPSVLKDLAEKGLIHNSESAVYLTHQGKLLGNEVFGAFLGEL*" gene complement(2495316..2496455) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" promotor_-10 complement(2496328..2496339) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-10" upshifts complement(2496332) /Source="Nicolas_upshifts" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" promotor_-35 complement(2496353..2496359) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-35" CDS complement(2496508..2498346) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12511492, 17110332, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal elongation factor, GTPase" /protein_id="NP_390429.1" /db_xref="EnsemblGenomes-Gn:BSU25510" /db_xref="EnsemblGenomes-Tr:CAB14493" /db_xref="GOA:P37949" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006297" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR013842" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035654" /db_xref="SubtiList:BG10441" /db_xref="UniProtKB/Swiss-Prot:P37949" /translation="MTDKEKRLERQSRIRNFSIIAHIDHGKSTLADRILEKTSAITQR EMKEQLLDSMDLERERGITIKLNSVQLKYKAKDGEEYIFHLIDTPGHVDFTYEVSRSL AACEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPSAEPERVRQEVEDV IGLDASEAVLASAKAGIGIEEILEQIVEKVPAPTGDPEAPLKALIFDSLYDAYRGVVA YIRVVEGTVKPGQKIKMMATGKEFEVTEVGVFTPKATPTNELTVGDVGFLTASIKNVG DTRVGDTITSAANPAEEALPGYRKLNPMVYCGLYPIDTAKYNDLREALEKLELNDSSL QYEAETSQALGFGFRCGFLGMLHMEIIQERIEREFNIDLITTAPSVIYDVYMTDGEKV VVDNPSNMPDPQKIERVEEPYVKATMMVPNDYVGAVMELCQGKRGNFIDMQYLDANRV SIIYDMPLAEIVYEFFDQLKSSTKGYASFDYELIGYKPSKLVKMDIMLNGEKIDALSF IVHRDYAYERGKVIVEKLKELIPRQQFEVPVQAAIGQKIVARSTIKAMRKNVLAKCYG GDISRKRKLLEKQKEGKRRMKQVGSVEVPQEAFMAVLKMDDSPKKQ*" gene complement(2496508..2498346) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" downshifts complement(2496530) /Source="Nicolas_upshifts" /id="D1319" /incds=0 /nref=15 /ntot=213 /MaxReadThrough="5.2925" /MaxDrop="3.979" /score="5.45344919" /energy="-14" /TU="U1985" /idTUdmin="U1984" /TUdmin="-1232" /isTUend="FALSE" promotor_-10 complement(2498381..2498400) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2498398) /Source="Nicolas_upshifts" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" promotor_-35 complement(2498416..2498420) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2498480..2498818) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390430.1" /db_xref="EnsemblGenomes-Gn:BSU25520" /db_xref="EnsemblGenomes-Tr:CAB14494" /db_xref="InterPro:IPR020534" /db_xref="SubtiList:BG10440" /db_xref="UniProtKB/Swiss-Prot:P38425" /translation="MIAYFGKCLLLVTIMFLGVLFGMQQANHGMLSMKGYHDPSLKGA FTLTDGKDNEKEASILGETVTAKDLVEKQKELEKVETFNMFSKAGKALSDTVTNTAQS MYEWIRDMNQ*" gene complement(2498480..2498818) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" downshifts complement(2498486) /Source="Nicolas_upshifts" /id="D1320" /incds=0 /nref=11 /ntot=43 /MaxReadThrough="2.553" /MaxDrop="3.8126" /score="5.45344919" /energy="-14" /TU="NA" /idTUdmin="U1986" /TUdmin=2 /isTUend="TRUE" CDS complement(2498835..2500040) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17376078, 23834622" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17376078, 23834622; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore autolysin (stage II sporulation)" /protein_id="NP_390431.1" /db_xref="EnsemblGenomes-Gn:BSU25530" /db_xref="EnsemblGenomes-Tr:CAB14495" /db_xref="GOA:P37968" /db_xref="InterPro:IPR010897" /db_xref="SubtiList:BG10439" /db_xref="UniProtKB/Swiss-Prot:P37968" /translation="MRNKRRNRQIVVAVNGGKAVKAIFLFIVSLIVIFVLSGVLTSLR PELRPSSDSFYGIAEELPGDVFAHLLQMENHYFASDLSQTDSSFHLSRLSLKLATSIN LEDPRSFLGRELPGFAQFDTEILLAGQGTDYTNMPAESPPPSKVMEEEREANLAEIEK QQTQSDNAQKDPPKQTTGDKKVVFIYHTHNTESYLPLLKGETDPDMARHSKANVTLVG DMFGQALESQGIGATVNKTDIQSKLNKKGLNYARSYDESRPVVKDALASNKNLQYIID IHRDSRRKKDTTATIKGKSYARVAFVVGKKSKNFEENYKIASELHKLMEKKYPGLSTG VFSKGSPGDNGVYNQDLTDRALLLEFGGVDNNLEELQRAANAAADVFSEMYWDAEKVN AASGETKKQ*" gene complement(2498835..2500040) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" promotor_-10 complement(2500060..2500078) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2500072) /Source="Nicolas_upshifts" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" promotor_-35 complement(2500094..2500099) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2500103..2501209) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" /EC_number="3.4.24.78" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10666631, 10986255, 12807468, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666631, 10986255, 12807468, 23927687; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protease" /protein_id="NP_390432.1" /db_xref="EnsemblGenomes-Gn:BSU25540" /db_xref="EnsemblGenomes-Tr:CAB14496" /db_xref="GOA:P22322" /db_xref="InterPro:IPR005080" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10438" /db_xref="UniProtKB/Swiss-Prot:P22322" /translation="MKKSELDVNQYLIRTDLAVETKEAMANQQAVPTKEIKGFIEKER DHGGIKIRTVDVTKEGAELSGKKEGRYLTLEAQGIRENDSEMQEKVSAVFAEEFSAFL ENLNISKDASCLIVGLGNWNVTPDALGPMAVENLLVTRHLFKLQPENVQEGYRPVSAF APGVMGITGIETSDIIKGVIEQSKPDFVIAIDALAARAVERVNTTIQISDTGIHPGSG VGNKRKDLSKDTLGVPVIAIGVPTVVDAVTIASDTVDYILKHFGREMKDNRPSRSLVP AGMTFGKKKVLTEDDLPDQKQRQSFLGIVGTLQEDEKRQLIHEVLSPLGHNLMVTPKE VDSFIDDMANVLANGLNTALHEKVSQENKGSYNH*" gene complement(2500103..2501209) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" promotor_-10 complement(2501237..2501248) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2501244) /Source="Nicolas_upshifts" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" promotor_-35 complement(2501263..2501269) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2501308..2501311 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2501324 /Source="Nicolas_upshifts" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" promotor_-10 2501327..2501346 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2501338..2501412 /Source="Nicolas_S_feature" /locus_tag="new_2635740_2635814" /HighExp="HiTm, LPhT, UNK1, HiOs, dia5, aero, MG 15, SMM, Lbtran, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S961" CDS 2501413..2501679 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16629673, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16629673, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S20 (BS20)" /protein_id="NP_390433.2" /db_xref="EnsemblGenomes-Gn:BSU25550" /db_xref="EnsemblGenomes-Tr:CAB14497" /db_xref="GOA:P21477" /db_xref="InterPro:IPR002583" /db_xref="InterPro:IPR036510" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11643" /db_xref="UniProtKB/Swiss-Prot:P21477" /translation="MPNIKSAIKRTKTNNERRVHNATIKSAMRTAIKQVEASVANNEA DKAKTALTEAAKRIDKAVKTGLVHKNTAARYKSRLAKKVNGLSA*" gene 2501413..2501679 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" downshifts 2501668 /Source="Nicolas_upshifts" /id="D1321" /incds=0 /nref=244 /ntot=274 /MaxReadThrough="2.22204" /MaxDrop="8.54705" /score="33.3621187" /energy="-12.3" /TU="NA" /idTUdmin="U1988" /TUdmin=0 /isTUend="TRUE" CDS complement(2501694..2502737) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9434186, 11432857, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9434186, 11432857, 12060778, 12682299, 22333191, 23525462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase clamp loader delta subunit" /protein_id="NP_390434.1" /db_xref="EnsemblGenomes-Gn:BSU25560" /db_xref="EnsemblGenomes-Tr:CAB14498" /db_xref="GOA:P54459" /db_xref="InterPro:IPR005790" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR010372" /db_xref="InterPro:IPR027417" /db_xref="PDB:3ZH9" /db_xref="SubtiList:BG11642" /db_xref="UniProtKB/Swiss-Prot:P54459" /translation="MVFDVWKSLKKGEVHPVYCLYGKETYLLQETVSRIRQTVVDQET KDFNLSVFDLEEDPLDQAIADAETFPFMGERRLVIVKNPYFLTGEKKKEKIEHNVSAL ESYIQSPAPYTVFVLLAPYEKLDERKKLTKALKKHAFMMEAKELNAKETTDFTVNLAK TEQKTIGTEAAEHLVLLVNGHLSSIFQEIQKLCTFIGDREEITLDDVKMLVARSLEQN IFELINKIVNRKRTESLQIFYDLLKQNEEPIKIMALISNQFRLILQTKYFAEQGYGQK QIASNLKVHPFRVKLAMDQARLFSEEELRLIIEQLAVMDYEMKTGKKDKQLLLELFLL QLLKRNEKNDPHY*" gene complement(2501694..2502737) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" downshifts complement(2501739) /Source="Nicolas_upshifts" /id="D1322" /incds=0 /nref=14 /ntot=198 /MaxReadThrough="1.76478" /MaxDrop="4.34213" /score="-1.12561483" /energy="-8.1" /TU="NA" /idTUdmin="U1989" /TUdmin=5 /isTUend="TRUE" promotor_-10 complement(2502766..2502785) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2502777..2502926) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513978.1" /translation="MKNLEAKVTFSVLVIIAFLQAVPGACEQAFNINGEAAVRLPLYY FANSI*" gene complement(2502777..2502926) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" upshifts complement(2502778) /Source="Nicolas_upshifts" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" promotor_-35 complement(2502799..2502803) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2502801..2503140) /Source="Nicolas_S_feature" /locus_tag="new_2637203_2637542_c" /HighExp="S8, S6, S7, BT, S5, C30, Pyr, G/S, B36, GM 150" /AntisenseName="yqzM" /AntisenseCor="-2.0369593011890001E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S962" downshifts complement(2502844) /Source="Nicolas_upshifts" /id="D1323" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="5.04584" /MaxDrop="3.298" /score="-1.12561483" /energy="-8.1" /TU="U1991,U1995" /idTUdmin="U1992" /TUdmin=748 /isTUend="FALSE" promotor_-35 2502913..2502919 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2502933..2502952 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2502934 /Source="Nicolas_upshifts" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" CDS 2502967..2503101 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097762.1" /db_xref="EnsemblGenomes-Gn:BSU25569" /db_xref="EnsemblGenomes-Tr:CAX52662" /db_xref="GOA:C0H453" /db_xref="InterPro:IPR025416" /db_xref="UniProtKB/Swiss-Prot:C0H453" /translation="MNDFEKNVQSKRNDAVDSAVGFVVSFGFFAFLFVMATVIHLVGS *" gene 2502967..2503101 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" downshifts 2503095 /Source="Nicolas_upshifts" /id="D1324" /incds=0 /nref=156 /ntot=250 /MaxReadThrough="3.51266" /MaxDrop="6.2258" /score="20.1810918" /energy="-12.1" /TU="U1990" /idTUdmin="U1990" /TUdmin="-465" /isTUend="FALSE" CDS complement(2503141..2505471) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12123453, 15661011, 16751195, 17630974, 21397556, 27318187" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123453, 15661011, 16751195, 17630974, 21397556, 27318187; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="DNA channel for uptake in competent cells" /protein_id="NP_390435.1" /db_xref="EnsemblGenomes-Gn:BSU25570" /db_xref="EnsemblGenomes-Tr:CAB14499" /db_xref="GOA:P39695" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004477" /db_xref="InterPro:IPR004797" /db_xref="InterPro:IPR025405" /db_xref="InterPro:IPR035681" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG10482" /db_xref="UniProtKB/Swiss-Prot:P39695" /translation="MRNSRLLLPMAAASATAGITAAAYFPAIFLFILFLLIILIKTRH AFLIIVCFFSFILFFVLYAVTDSQNVSSYRQGTYQFKAVIDTIPKIDGDRMSMMVETP DKEKWAAAYRIQSAGEKEQLLYIEPGMSCELTGTLEEPNHATVPGAFDYNEYLYRQHI HWNYSVTSIQNCSEPENFKYKVLSLRKHIISFTNSLLPPDSTGIVQALTVGDRFYVED EVLTAYQKLGVVHLLAISGLHVGILTAGLFYIMIRLGITREKASILLLLFLPLYVMLT GAAPSVLRAALMSGVYLAGSLVKWRVRSATAICLSYIVLLLFNPYHLFEAGFQLSFAV SFSLILSSSIFQQVKTSLGQLTIVSLIAQLGSLPILLYHFHQFSIISVPMNMLMVPFY TFCILPGAVAGVLLLSLSASFGRLFFSWFDLLISWINRLITNIADVDVFTIMIAHPAP VLLFLFTVTIILLLMAIEKRSLSQLMVTGGICCTVMFLLFIYPCLSSEGEVDMIDIGQ GDSMFVGAPHQRGRVLIDTGGTLSYSSEPWREKQHPFSLGEKVLIPFLTAKGIKQLDA LILTHADQDHIGEAEILLKHHKVKRLVIPKGFVSEPKDEKVLQAAREEGVAIEEVKRG DVLQIKDLQFHVLSPEAPDPASKNNSSLVLWMETGGMSWILTGDLEKEGEQEVMNVFP NIKADVLKVGHHGSKGSTGEEFIQQLQPKTAIISAGKNNRYHHPHQKVLQLLQRHSIR VLRTDQNGTIQYRYKNRVGTFSVYPPYDTSDITETN*" gene complement(2503141..2505471) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" promotor_-10 complement(2503158..2503177) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2503174) /Source="Nicolas_upshifts" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" promotor_-35 complement(2503191..2503200) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2505475..2506044) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" /EC_number="3.5.4.12" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7768800, 26416910; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="dCMP deaminase associated to DNA transport (competence)" /protein_id="NP_390436.1" /db_xref="EnsemblGenomes-Gn:BSU25580" /db_xref="EnsemblGenomes-Tr:CAB14500" /db_xref="GOA:P32393" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR013404" /db_xref="InterPro:IPR015517" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR016473" /db_xref="InterPro:IPR035105" /db_xref="SubtiList:BG10481" /db_xref="UniProtKB/Swiss-Prot:P32393" /translation="MERISWNQYFMAQSHLLALRSTCPRLSVGATIVRDKRMIAGGYN GSIAGGVHCADEGCLMIDDHCARTIHAEMNAILQCSKFGVPTDGAEIYVTHYPCIQCC KSIIQAGIKTVYYAEDYKTHPYAQELFEQAGVTVEQVELDEMIVDLKNREKLSFVAGL IGKLADAGLAEEELKKIHEQANTLFTSYV*" gene complement(2505475..2506044) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" promotor_-10 complement(2506071..2506090) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2506081) /Source="Nicolas_upshifts" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" promotor_-35 complement(2506105..2506112) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2506111..2506728) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16751195, 21278288, 22398145, 25727469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751195, 21278288, 22398145, 25727469; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane bound high-affinity DNA-binding receptor" /protein_id="NP_390437.1" /db_xref="EnsemblGenomes-Gn:BSU25590" /db_xref="EnsemblGenomes-Tr:CAB14501" /db_xref="GOA:P39694" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004509" /db_xref="InterPro:IPR004787" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR019554" /db_xref="SubtiList:BG10480" /db_xref="UniProtKB/Swiss-Prot:P39694" /translation="MNWLNQHKKAIILAASAAVFTAIMIFLATGKNKEPVKQAVPTET ENTVVKQEANNDESNETIVIDIKGAVQHPGVYEMRTGDRVSQAIEKAGGTSEQADEAQ VNLAEILQDGTVVYIPKKGEETAVQQGGGGSVQSDGGKGALVNINTATLEELQGISGV GPSKAEAIIAYREENGRFQTIEDITKVSGIGEKSFEKIKSSITVK*" gene complement(2506111..2506728) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" promotor_-35 2506749..2506754 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2506766 /Source="Nicolas_upshifts" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" promotor_-10 2506770..2506788 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2506789..2506803) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2506791) /Source="Nicolas_upshifts" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" S_feature complement(2506793..2507640) /Source="Nicolas_S_feature" /locus_tag="new_2641195_2642042_c" /HighExp="C30, T0.30H, T-2.40H, GM 150, T1.30H, T-0.40H, T-1.10H, T-1.40H, T1.0H, T0.0H" /AntisenseName="comER" /AntisenseCor="-8.2389039371154299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S963" promotor_-35 complement(2506812..2506816) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2506812..2507633 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" /EC_number="1.5.1.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7968523, 11418582, 27446060, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrroline-5'-carboxylate reductase" /protein_id="NP_390438.1" /db_xref="EnsemblGenomes-Gn:BSU25600" /db_xref="EnsemblGenomes-Tr:CAB14502" /db_xref="GOA:P39696" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10479" /db_xref="UniProtKB/Swiss-Prot:P39696" /translation="MKIGFIGTGNMGTILIESFIESKAADPSNMTITNRTIEKALHIK NRYNSINVTESLEKLVSENEMIFICVKPLDIYPLLARALPYLRKDHILISITSPVQTE QLEQYVPCQVARVIPSITNRALAGVSLVTFGTSCGESAKAKINELMQHISHPLQIESD ITRVASDIVSCGPAFMSYLIQRFIDAAVSETSVSKQDAILMCKEMLVGMGKLLETELY TLPALQEKVCVKGGVTGEGIKALESGVQDMFHRVFQNTHMKYEEDISAVKKQFHV*" gene 2506812..2507633 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" promotor_-10 complement(2507628..2507647) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2507634..2507714 /Source="Nicolas_S_feature" /locus_tag="new_2642036_2642116" /HighExp="S4, S5, S3, S6, S7, B36, Pyr, G/S, S8, BT" /AntisenseName="yqeM" /AntisenseCor="-0.52267300854840604" /AntisenseRegPval="-19.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S964" upshifts complement(2507641) /Source="Nicolas_upshifts" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" promotor_-35 complement(2507661..2507668) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2507674 /Source="Nicolas_upshifts" /id="D1325" /incds=0 /nref=45 /ntot=64 /MaxReadThrough="2.4803" /MaxDrop="5.1403" /score="7.09525061" /energy="-10.5" /TU="NA" /idTUdmin="U1993" /TUdmin=0 /isTUend="TRUE" CDS complement(2507699..2508442) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390439.1" /db_xref="EnsemblGenomes-Gn:BSU25610" /db_xref="EnsemblGenomes-Tr:CAB14503" /db_xref="GOA:P54458" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11641" /db_xref="UniProtKB/Swiss-Prot:P54458" /translation="MIYQGFASVYDELMSHAPYDQWTKWIEASLPEKGRILDLACGTG EISIRLAEKGFEVTGIDLSEEMLSFAQQKVSSSQPILFLQQDMREITGFDGQFDAVVI CCDSLNYLKTKNDVIETFKSVFRVLKPEGILLFDVHSSFKIAEVFPDSTFADQDEDIS YIWQSFAGSDELSVIHDMSFFVWNGEAYDRFDETHEQRTFPVEEYEEMLKNCGFQLHR VTADFTDTEPSAQSERLFFKAQKSKTIVS*" gene complement(2507699..2508442) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" downshifts complement(2507729) /Source="Nicolas_upshifts" /id="D1326" /incds=0 /nref=144 /ntot=230 /MaxReadThrough="1.41467" /MaxDrop="5.51802" /score="7.9251293" /energy="-10.5" /TU="NA" /idTUdmin="U1996" /TUdmin="-1" /isTUend="TRUE" CDS complement(2508439..2508795) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 16980477, 22238375, 22238376, 22829778, 26299947; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal silencing factor" /protein_id="NP_390440.1" /db_xref="EnsemblGenomes-Gn:BSU25620" /db_xref="EnsemblGenomes-Tr:CAB14504" /db_xref="GOA:P54457" /db_xref="InterPro:IPR004394" /db_xref="SubtiList:BG11640" /db_xref="UniProtKB/Swiss-Prot:P54457" /translation="MNQKSILKIAAAACDDKRAEDILALDMEGISLVADYFLICHGNS DKQVQAIAREIKDQADENGIQVKKMEGFDEARWVLVDLGDVVVHVFHKDERSYYNLEK LWGDAPLADLDFGMNQ*" gene complement(2508439..2508795) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" CDS complement(2508813..2509373) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390441.1" /db_xref="EnsemblGenomes-Gn:BSU25630" /db_xref="EnsemblGenomes-Tr:CAB14505" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR005249" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11639" /db_xref="UniProtKB/Swiss-Prot:P54456" /translation="MNREEALACVKQQLTEHRYIHTVGVMNTAIELAERFGADSKKAE IAAIFHDYAKFRPKEEMKQIIAREKMPAHLLDHNPELWHAPVGAYLVQREAGVQDEDI LDAIRYHTSGRPGMTLLEKVIYVADYIEPNRAFPGVDEVRKLAETDLNQALIQSIKNT MVFLMKKNQPVFPDTFLTYNWLVSGS*" gene complement(2508813..2509373) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" CDS complement(2509363..2509932) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" /EC_number="2.7.7.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11704676, 12682299, 19716475, 23204464, 25631047; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide adenylyltransferase" /protein_id="NP_390442.1" /db_xref="EnsemblGenomes-Gn:BSU25640" /db_xref="EnsemblGenomes-Tr:CAB14506" /db_xref="GOA:P54455" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR005248" /db_xref="InterPro:IPR014729" /db_xref="PDB:1KAM" /db_xref="PDB:1KAQ" /db_xref="SubtiList:BG11638" /db_xref="UniProtKB/Swiss-Prot:P54455" /translation="MKKIGIFGGTFDPPHNGHLLMANEVLYQAGLDEIWFMPNQIPPH KQNEDYTDSFHRVEMLKLAIQSNPSFKLELVEMEREGPSYTFDTVSLLKQRYPNDQLF FIIGADMIEYLPKWYKLDELLNLIQFIGVKRPGFHVETPYPLLFADVPEFEVSSTMIR ERFKSKKPTDYLIPDKVKKYVEENGLYES*" gene complement(2509363..2509932) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" CDS complement(2509944..2510234) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 17005971, 17105995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 17005971, 17105995; Product type f: factor" /codon_start=1 /transl_table=11 /product="50S RNA-binding protein" /protein_id="NP_390443.1" /db_xref="EnsemblGenomes-Gn:BSU25650" /db_xref="EnsemblGenomes-Tr:CAB14507" /db_xref="GOA:P54454" /db_xref="InterPro:IPR001890" /db_xref="InterPro:IPR017924" /db_xref="InterPro:IPR035920" /db_xref="SubtiList:BG11637" /db_xref="UniProtKB/Swiss-Prot:P54454" /translation="MLTGKQKRFLRSKAHHLTPIFQVGKGGVNDNMIKQIAEALEARE LIKVSVLQNCEEDKNDVAEALVKGSRSQLVQTIGNTIVLYKESKENKQIELP*" gene complement(2509944..2510234) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" CDS complement(2510228..2511070) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" /EC_number="1.1.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2104604, 12906820, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate 5-dehydrogenase" /protein_id="NP_390444.2" /db_xref="EnsemblGenomes-Gn:BSU25660" /db_xref="EnsemblGenomes-Tr:CAB14508" /db_xref="GOA:P54374" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR011342" /db_xref="InterPro:IPR013708" /db_xref="InterPro:IPR022893" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11522" /db_xref="UniProtKB/Swiss-Prot:P54374" /translation="MKKLYGVIGNPIGHSMSPDIHNASLKDLGLDGHYHAFKVEENDL EDAVKGIRALGVQGINVTVPHKVSIMDYLDHIDESAKVLGAVNTVRREGDKLVGYNTD GEGFVKSLMKVLDKPISELSFLMIGAGGAARAIFTTIVRNTPKKFDICNRTLEKAKRL TEATPSFHNKEVLSIKEAEERLEQYDVIIHTTSVGMYPNVDDVPLSLQRAASSAVVCD IVYNPIQTALLKEASQKGLKTLDGVGMFVEQAALSFQLWTGQEPNIEKMRSIVIGKLG GTEC*" gene complement(2510228..2511070) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" downshifts 2511062 /Source="Nicolas_upshifts" /id="D1327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="0.240279999999999" /MaxDrop="3.04009" /score="0.0642154872" /energy="-17" /TU="NA" /idTUdmin="U1993" /TUdmin=3388 /isTUend="FALSE" CDS complement(2511088..2512188) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent GTPase involved in ribosome 30S assembly" /protein_id="NP_390445.1" /db_xref="EnsemblGenomes-Gn:BSU25670" /db_xref="EnsemblGenomes-Tr:CAB14509" /db_xref="GOA:P54453" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019988" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="SubtiList:BG11636" /db_xref="UniProtKB/Swiss-Prot:P54453" /translation="MEKVVCIGCGVTIQTEDKTGLGYAPPASLTKENVICQRCFRLKN YNEIQDVSLTDDDFLNILHGIGETDSLVVKIVDIFDFNGSWINGLQRLVGGNPILLVG NKADILPKSLKRERLIQWMKREAKELGLKPVDVFLVSAGRGQGIREVIDAIEHYRNGK DVYVVGCTNVGKSTFINRIIKEVSGEEDIITTSQFPGTTLDAIEIPLDDGSSLYDTPG IINNHQMAHYVNKKDLKILSPKKELKPRTFQLNDQQTLYFGGLARFDYVSGERSPFIC YMPNELMIHRTKLENADALYEKHAGELLTPPGKDEMDEFPELVAHTFTIKDKKTDIVF SGLGWVTVHDADKKVTAYAPKGVHVFVRRSLI*" gene complement(2511088..2512188) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" CDS complement(2512192..2512710) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase (active on GMP and Glc-6-P)" /protein_id="NP_390446.1" /db_xref="EnsemblGenomes-Gn:BSU25680" /db_xref="EnsemblGenomes-Tr:CAB14510" /db_xref="GOA:P54452" /db_xref="InterPro:IPR006356" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR006549" /db_xref="InterPro:IPR010021" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11635" /db_xref="UniProtKB/Swiss-Prot:P54452" /translation="MLKKFFLPDEFVKNIFHITPEKLKERNVKGIITDLDNTLVEWDR PNATPRLIEWFEEMKEHGIKVTIVSNNNERRVKLFSEPLGIPFIYKARKPMGKAFNRA VRNMELKKEDCVVIGDQLLTDVLGGNRNGYHTILVVPVASSDGFITRFNRQVERRILS ALKRKGHIQWEE*" gene complement(2512192..2512710) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" promotor_-10 complement(2512620..2512637) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2512634) /Source="Nicolas_upshifts" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" promotor_-35 complement(2512653..2512656) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2512711..2513272) /Source="Nicolas_S_feature" /locus_tag="new_2647113_2647674_c" /HighExp="G135, G180, G150, Paraq, Oxctl, C30, Heat, HPh, BMM, LPh" /AntisenseName="sda" /AntisenseCor="-8.6107693225382295E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S965" downshifts complement(2512744) /Source="Nicolas_upshifts" /id="D1328" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="6.83118" /MaxDrop="5.26138" /score="9.20556883" /energy="-8.6" /TU="U1998" /idTUdmin="U1999" /TUdmin=616 /isTUend="FALSE" promotor_-35 2512935..2512942 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2512953..2513053 /Source="Nicolas_S_feature" /locus_tag="new_2647355_2647455" /HighExp="T3.0H, T-0.40H, MG 150, T5.0H, T-1.40H, T4.0H, T2.30H, T0.0H, T3.30H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S966" promotor_-10 2512953..2512972 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2512953 /Source="Nicolas_upshifts" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" misc_RNA complement(2513003..2513261) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" /product="antisense RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" gene complement(2513003..2513261) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" CDS 2513054..2513212 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15023339, 16796683, 19040634, 22720735, 28752667" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15023339, 16796683, 19040634, 22720735, 28752667; Product type f: factor" /codon_start=1 /transl_table=11 /product="check point factor coupling initiation of sporulation and replication initiation" /protein_id="YP_054588.1" /db_xref="EnsemblGenomes-Gn:BSU25690" /db_xref="EnsemblGenomes-Tr:CAE01463" /db_xref="GOA:Q7WY62" /db_xref="InterPro:IPR015064" /db_xref="InterPro:IPR036916" /db_xref="PDB:1PV0" /db_xref="PDB:3FYR" /db_xref="SubtiList:BG14183" /db_xref="UniProtKB/Swiss-Prot:Q7WY62" /translation="MNWVPSMRKLSDELLIESYFKATEMNLNRDFIELIENEIKRRSL GHIISVSS*" gene 2513054..2513212 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" S_feature 2513213..2513459 /Source="Nicolas_S_feature" /locus_tag="new_2647615_2647861" /HighExp="Cold, T-0.40H, MG 150, T5.0H, T4.0H, C30, T2.30H, M9-tran, S2, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S967" promotor_-10 complement(2513260..2513279) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2513271) /Source="Nicolas_upshifts" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" promotor_-35 complement(2513295..2513299) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2513323..2513470) /Source="Nicolas_S_feature" /locus_tag="new_2647725_2647872_c" /HighExp="S8, S7, S6, Etha, LBGstat, T0.30H, Salt, BT, LPhT, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99948400000000004" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S968" downshifts complement(2513360) /Source="Nicolas_upshifts" /id="D1329" /incds=0 /nref=12 /ntot=92 /MaxReadThrough="2.70676" /MaxDrop="4.386" /score="9.20556883" /energy="-8.6" /TU="NA" /idTUdmin="U1999" /TUdmin=0 /isTUend="TRUE" downshifts 2513416 /Source="Nicolas_upshifts" /id="D1330" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="5.36291" /MaxDrop="2.1106" /score="10.3636587" /energy="-6.2" /TU="U1997" /idTUdmin="U1997" /TUdmin="-1056" /isTUend="FALSE" S_feature 2513461..2514514 /Source="Nicolas_S_feature" /locus_tag="new_2647863_2648916" /HighExp="T-0.40H, Cold, M40t90, T0.0H, C30, Glucon, S2, T1.30H, T2.30H, T2.0H" /AntisenseName="yqeF" /AntisenseCor="-0.39616310996746001" /AntisenseRegPval="-10.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S969" promotor_-10 complement(2513465..2513484) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2513470) /Source="Nicolas_upshifts" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" promotor_-35 complement(2513497..2513506) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2513518..2514249) /gene="yqeF" /locus_tag="BSU_25700" /old_locus_tag="BSU25700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipoprotein; putative esterase" /protein_id="NP_390447.1" /db_xref="EnsemblGenomes-Gn:BSU25700" /db_xref="EnsemblGenomes-Tr:CAB14511" /db_xref="GOA:P54451" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11634" /db_xref="UniProtKB/Swiss-Prot:P54451" /translation="MKHFIILFLLLFVTAGCEGRGYEDVVAFGDSNTRGSNWDYRDYP KAQQWVNILKTAERGNLDILNAGIGGQTTEDARLRFQTDVLDQKPKYLFIMFGTNDAA ILTEGKPRVSKQRFRENLVYFIEESRKHGIKPILMTCIPIIEGNGKHHLFYYSRYQAA AFEPKGGARKWHNSYNDITRDVSKRLDVPLVDNWKHFIEADGGKATDEALIQSGLIDP SGNHMTPKGARIVYEGIQDGQILQR*" gene complement(2513518..2514249) /gene="yqeF" /locus_tag="BSU_25700" /old_locus_tag="BSU25700" promotor_-10 complement(2514268..2514287) /Source="Nicolas_upshift_promotors" /id="U2000" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.380619380619381" /psig=1 /xcortree=2739 /SigmaFactorBS="taactataggaaaaaacagtgatagcgaaaaactcttCATTG AAcgaagagaaacagAGGTATAACATTAAAGTGAGgcttttgggggtgtaaagatgaa a" /listShort="yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2514284) /Source="Nicolas_upshifts" /id="U2000" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.380619380619381" /psig=1 /xcortree=2739 /SigmaFactorBS="taactataggaaaaaacagtgatagcgaaaaactcttCATTG AAcgaagagaaacagAGGTATAACATTAAAGTGAGgcttttgggggtgtaaagatgaa a" /listShort="yqeF, S968" /GFF_Attribute="listLong" S_feature complement(2514286..2514394) /Source="Nicolas_S_feature" /locus_tag="new_2648688_2648796_c" /HighExp="Etha, Salt, Gly, S8, C30, S7, LPhT, Sw, Heat, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S970" promotor_-35 complement(2514301..2514307) /Source="Nicolas_upshift_promotors" /id="U2000" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.380619380619381" /psig=1 /xcortree=2739 /SigmaFactorBS="taactataggaaaaaacagtgatagcgaaaaactcttCATTG AAcgaagagaaacagAGGTATAACATTAAAGTGAGgcttttgggggtgtaaagatgaa a" /listShort="yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2514395..2514413) /Source="Nicolas_upshift_promotors" /id="U2001" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=162 /SigmaFactorBS="tttccagtgcggattcaggttattttcttttctttggtttgt gTGTTTTtcagattggaaagaAGGGAATTTTAAAAAATCAtcagctgcgccgcaatga a" /listShort="S970, yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2514416) /Source="Nicolas_upshifts" /id="U2001" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=162 /SigmaFactorBS="tttccagtgcggattcaggttattttcttttctttggtttgt gTGTTTTtcagattggaaagaAGGGAATTTTAAAAAATCAtcagctgcgccgcaatga a" /listShort="S970, yqeF, S968" /GFF_Attribute="listLong" promotor_-35 complement(2514428..2514433) /Source="Nicolas_upshift_promotors" /id="U2001" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=162 /SigmaFactorBS="tttccagtgcggattcaggttattttcttttctttggtttgt gTGTTTTtcagattggaaagaAGGGAATTTTAAAAAATCAtcagctgcgccgcaatga a" /listShort="S970, yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2514501..2515253) /gene="cwlH" /locus_tag="BSU_25710" /old_locus_tag="BSU25710" /EC_number="3.5.1.28" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10515909, 10974124, 15687192" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10515909, 10974124, 15687192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_390448.1" /db_xref="EnsemblGenomes-Gn:BSU25710" /db_xref="EnsemblGenomes-Tr:CAB14512" /db_xref="GOA:P54450" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR002502" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="InterPro:IPR036505" /db_xref="SubtiList:BG11633" /db_xref="UniProtKB/Swiss-Prot:P54450" /translation="MVTIKKDFIPVSNDNRPGYAMAPAYITVHNTANTAKGADAKMHA KFVKNPNTSESWHFTVDDSVIYQHLPIDENGWHAGDGTNGTGNRKSIGIEICENADGD FEKATSNAQWLIRKLMKENNIPLNRVVPHKKWSGKECPRKLLDHWNSFLNGISSSDTP PKETSPSYPLPSGVIKLTSPYRKGTNILQLQKALAVLHFYPDKGAKNNGIDGVYGPKT ANAVKRFQLMNGLTADGIYGPKTKAKLKSKLK*" gene complement(2514501..2515253) /gene="cwlH" /locus_tag="BSU_25710" /old_locus_tag="BSU25710" downshifts complement(2514504) /Source="Nicolas_upshifts" /id="D1331" /incds=0 /nref=4 /ntot=10 /MaxReadThrough="1.29819" /MaxDrop="4.65121" /score="4.6304411" /energy="-10.7" /TU="NA" /idTUdmin="U2003" /TUdmin=0 /isTUend="TRUE" promotor_-35 2514632..2514638 /Source="Nicolas_upshift_promotors" /id="U2002" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=171 /SigmaFactorBS="ctgttttcggtccgtaaactccatctatgccatTGTTTTTgg ctcccttatcaGGGTAAAAGTGAAGTACAGctaaagccttttgcagctggagaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2514652..2514670 /Source="Nicolas_upshift_promotors" /id="U2002" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=171 /SigmaFactorBS="ctgttttcggtccgtaaactccatctatgccatTGTTTTTgg ctcccttatcaGGGTAAAAGTGAAGTACAGctaaagccttttgcagctggagaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2514659 /Source="Nicolas_upshifts" /id="U2002" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=171 /SigmaFactorBS="ctgttttcggtccgtaaactccatctatgccatTGTTTTTgg ctcccttatcaGGGTAAAAGTGAAGTACAGctaaagccttttgcagctggagaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2515263..2515282) /Source="Nicolas_upshift_promotors" /id="U2003" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.898101898101898" /psig="0.898101898101898" /xcortree=1426 /SigmaFactorBS="caggttaagaacacaattcttttttacctcataaaaaaGGCT GTCCAtctctctgttttcTGCATTCTTATTAATAGGGAgggatagaaatggtaaccat a" /listShort="cwlH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2515282) /Source="Nicolas_upshifts" /id="U2003" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.898101898101898" /psig="0.898101898101898" /xcortree=1426 /SigmaFactorBS="caggttaagaacacaattcttttttacctcataaaaaaGGCT GTCCAtctctctgttttcTGCATTCTTATTAATAGGGAgggatagaaatggtaaccat a" /listShort="cwlH" /GFF_Attribute="listLong" promotor_-35 complement(2515296..2515304) /Source="Nicolas_upshift_promotors" /id="U2003" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.898101898101898" /psig="0.898101898101898" /xcortree=1426 /SigmaFactorBS="caggttaagaacacaattcttttttacctcataaaaaaGGCT GTCCAtctctctgttttcTGCATTCTTATTAATAGGGAgggatagaaatggtaaccat a" /listShort="cwlH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2515348..2515355 /Source="Nicolas_upshift_promotors" /id="U2004" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1830 /SigmaFactorBS="aggtaaaaaagaattgtgttcttaacctggttttCAGTTGAA cagctgaaatggcaCCAGTTATACTAATTTAGATgacggaggttttgactcctgacat c" /listShort="S971, yqeD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2515370..2515389 /Source="Nicolas_upshift_promotors" /id="U2004" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1830 /SigmaFactorBS="aggtaaaaaagaattgtgttcttaacctggttttCAGTTGAA cagctgaaatggcaCCAGTTATACTAATTTAGATgacggaggttttgactcctgacat c" /listShort="S971, yqeD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2515374..2515439 /Source="Nicolas_S_feature" /locus_tag="new_2649776_2649841" /HighExp="dia15, H2O2, C30, G180, Heat, S8, Paraq, Oxctl, LBGexp, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S971" upshifts 2515374 /Source="Nicolas_upshifts" /id="U2004" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1830 /SigmaFactorBS="aggtaaaaaagaattgtgttcttaacctggttttCAGTTGAA cagctgaaatggcaCCAGTTATACTAATTTAGATgacggaggttttgactcctgacat c" /listShort="S971, yqeD" /GFF_Attribute="listLong" CDS 2515440..2516066 /gene="yqeD" /locus_tag="BSU_25720" /old_locus_tag="BSU25720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 15855514, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390449.1" /db_xref="EnsemblGenomes-Gn:BSU25720" /db_xref="EnsemblGenomes-Tr:CAB14513" /db_xref="GOA:P54449" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG11632" /db_xref="UniProtKB/Swiss-Prot:P54449" /translation="MLKKVIGILVIIAIISVGFFQKEAWLDAIKAGGMFSVLFSMLLI AADVFFPIVPFALIAALNGAVFGTANGIWITLTGSMLGTILLFFLARYSFRDWARKKV QAYPAIQSYEASFNKNAFTAVLLGRLIPVIPSLVMNVICGLSQVRWHVFFFASLIGKI PNIVVVTIAGANFTSNKLLSISIYGTYILIIMLVIYKKFPHLLKVPKK*" gene 2515440..2516066 /gene="yqeD" /locus_tag="BSU_25720" /old_locus_tag="BSU25720" downshifts 2516034 /Source="Nicolas_upshifts" /id="D1332" /incds=0 /nref=2 /ntot=63 /MaxReadThrough="2.9326" /MaxDrop="2.91074" /score="15.7108141" /energy="-10.3" /TU="U2004" /idTUdmin="U2004" /TUdmin="-22" /isTUend="TRUE" CDS complement(2516085..2516978) /gene="yqeC" /locus_tag="BSU_25730" /old_locus_tag="BSU25730" /EC_number="1.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10658669, 15231785; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative catabolic 6-phospho-gluconate dehydrogenase (NAD[+]-dependent)" /protein_id="NP_390450.1" /db_xref="EnsemblGenomes-Gn:BSU25730" /db_xref="EnsemblGenomes-Tr:CAB14514" /db_xref="GOA:P54448" /db_xref="InterPro:IPR004849" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11631" /db_xref="UniProtKB/Swiss-Prot:P54448" /translation="MKIGLIGLGKMGINIGKQFIDRNHQVVGYDVNQAAVDELKAYGA EGTTNLKEFISLLHPPRILWVMVPHGIVDAVLRDVSPLLSKGDMIIEAGNSHYKESIR RYNQMKEAGIHYLDAGTSGGMEGARHGACFMVGGDHEAWEIVEPLFRDTAVENGYLYA GEAGSGHFLKMIHNGIEYGMMAAIGEGFEVLENSQFDFDYEKVARVWNHGSVIRSWLM GLTERAFAKDAKLDQIKGIMHSSGEGKWTVETALDLQTATPVIAMSLMMRYRSLTDDT FTGKVVAALRNEFGGHATEKK*" gene complement(2516085..2516978) /gene="yqeC" /locus_tag="BSU_25730" /old_locus_tag="BSU25730" downshifts complement(2516110) /Source="Nicolas_upshifts" /id="D1333" /incds=0 /nref=4 /ntot=12 /MaxReadThrough="1.46947" /MaxDrop="3.03963" /score="0.698755756" /energy="-8.4" /TU="NA" /idTUdmin="U2003" /TUdmin="-1606" /isTUend="FALSE" promotor_-35 2517161..2517167 /Source="Nicolas_upshift_promotors" /id="U2005" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.874125874125874" /psig="0.998001998001998" /xcortree=3104 /SigmaFactorBS="tctattactgaatctctttatatccataattatcgctttatc CTTGATTtaccatcagttTAAGTTAAAATATGGGAAGGaattcgattttttcagtaaa a" /listShort="yqeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2517179..2517198 /Source="Nicolas_upshift_promotors" /id="U2005" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.874125874125874" /psig="0.998001998001998" /xcortree=3104 /SigmaFactorBS="tctattactgaatctctttatatccataattatcgctttatc CTTGATTtaccatcagttTAAGTTAAAATATGGGAAGGaattcgattttttcagtaaa a" /listShort="yqeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2517179 /Source="Nicolas_upshifts" /id="U2005" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.874125874125874" /psig="0.998001998001998" /xcortree=3104 /SigmaFactorBS="tctattactgaatctctttatatccataattatcgctttatc CTTGATTtaccatcagttTAAGTTAAAATATGGGAAGGaattcgattttttcagtaaa a" /listShort="yqeB" /GFF_Attribute="listLong" CDS 2517230..2517952 /gene="yqeB" /locus_tag="BSU_25740" /old_locus_tag="BSU25740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390451.2" /db_xref="EnsemblGenomes-Gn:BSU25740" /db_xref="EnsemblGenomes-Tr:CAB14515" /db_xref="GOA:P54447" /db_xref="SubtiList:BG11630" /db_xref="UniProtKB/Swiss-Prot:P54447" /translation="MLQNQSHTLIGVTKTAVFFLYAALAIIGFAIGYFIPQIAKWALS LPWIPLEGPLRLITSFQGSTASFITALLGMCAGIWFAHSVIAMLLSVKITDHTVEFIK GKKVQTIHSDDIALVFMDHKRLVLLGTAGYELVREEIDEKPVNVEKAFRQHHYEWATD GDPFKDQFRRWIPDAPDLSQGAHALLKARHKALQDEEKDDIEEFRLELAQLGIVVRDE GTRQYWRKAETYPPKIQLGEGL*" gene 2517230..2517952 /gene="yqeB" /locus_tag="BSU_25740" /old_locus_tag="BSU25740" CDS complement(2517985..2518395) /gene="nucB" /locus_tag="BSU_25750" /old_locus_tag="BSU25750" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7746143, 17209033, 21179489" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746143, 17209033, 21179489; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation-specific matrix degrading exported DNase" /protein_id="NP_390452.1" /db_xref="EnsemblGenomes-Gn:BSU25750" /db_xref="EnsemblGenomes-Tr:CAB14516" /db_xref="GOA:P42983" /db_xref="InterPro:IPR029476" /db_xref="SubtiList:BG11237" /db_xref="UniProtKB/Swiss-Prot:P42983" /translation="MKKWMAGLFLAAAVLLCLMVPQQIQGASSYDKVLYFPLSRYPET GSHIRDAIAEGHPDICTIDRDGADKRREESLKGIPTKPGYDRDEWPMAVCEEGGAGAD VRYVTPSDNRGAGSWVGNQMSSYPDGTRVLFIVQ*" gene complement(2517985..2518395) /gene="nucB" /locus_tag="BSU_25750" /old_locus_tag="BSU25750" downshifts complement(2518010) /Source="Nicolas_upshifts" /id="D1334" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="0.80212" /MaxDrop="3.40706" /score="-0.144589925" /energy="-9.3" /TU="NA" /idTUdmin="U2006" /TUdmin="-11" /isTUend="TRUE" promotor_-10 complement(2518415..2518433) /Source="Nicolas_upshift_promotors" /id="U2006" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1115 /SigmaFactorBS="cagcatactaacttcaaatgttaAAAATAttcttcatcaagc gcCCATACATTGAAATGAACAaaggtatggggggatggggatgaaaaaatggatggca g" /listShort="nucB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2518417) /Source="Nicolas_upshifts" /id="U2006" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1115 /SigmaFactorBS="cagcatactaacttcaaatgttaAAAATAttcttcatcaagc gcCCATACATTGAAATGAACAaaggtatggggggatggggatgaaaaaatggatggca g" /listShort="nucB" /GFF_Attribute="listLong" promotor_-35 complement(2518449..2518454) /Source="Nicolas_upshift_promotors" /id="U2006" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1115 /SigmaFactorBS="cagcatactaacttcaaatgttaAAAATAttcttcatcaagc gcCCATACATTGAAATGAACAaaggtatggggggatggggatgaaaaaatggatggca g" /listShort="nucB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2518518..2518526 /Source="Nicolas_upshift_promotors" /id="U2007" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1062 /SigmaFactorBS="ttaccaaagccggactcccccgcgagaaatttcccggtaCAG ACACAGacagcctcccggtCACATACATTTACATATAGGcttttgcctacatactttt g" /listShort="spoIVCB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2518539 /Source="Nicolas_upshifts" /id="U2007" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1062 /SigmaFactorBS="ttaccaaagccggactcccccgcgagaaatttcccggtaCAG ACACAGacagcctcccggtCACATACATTTACATATAGGcttttgcctacatactttt g" /listShort="spoIVCB" /GFF_Attribute="listLong" promotor_-10 2518540..2518559 /Source="Nicolas_upshift_promotors" /id="U2007" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1062 /SigmaFactorBS="ttaccaaagccggactcccccgcgagaaatttcccggtaCAG ACACAGacagcctcccggtCACATACATTTACATATAGGcttttgcctacatactttt g" /listShort="spoIVCB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2518591..2519061 /gene="sigKn" /locus_tag="BSU_25760" /old_locus_tag="BSU25760" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8464402, 7704261, 2536191, 2163341, 10974124, 15187183, 20889742" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8464402, 7704261, 2536191, 2163341, 10974124, 15187183, 20889742; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma-K factor precursor (Sigma-27) (N-terminal half)" /db_xref="GOA:P12254" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="PSEUDO:CAB14517.2" /db_xref="SubtiList:BG10459" /db_xref="UniProtKB/Swiss-Prot:P12254" /translation="MVTGVFAALGFVVKELVFLVSYVKNNAFPQPLSSSEEKKYLELM AKGDEHARNMLIEHNLRLVAHIVKKFENTGEDAEDLISIGTIGLIKGIESYSAGKGTK LATYAARCIENEIVITKGGCIHPSLIRFNIYGVRIHNGNFFHDKVNNCFFIFKS*" gene 2518591..2519061 /gene="sigKn" /locus_tag="BSU_25760" /old_locus_tag="BSU25760" /pseudo downshifts 2518781 /Source="Nicolas_upshifts" /id="D1335" /incds=1 /nref=2 /ntot=5 /MaxReadThrough="7.53734" /MaxDrop="3.01863" /score="-7.46047649" /energy="-12.1" /TU="U2007" /idTUdmin="U2007" /TUdmin="-132" /isTUend="FALSE" downshifts 2518913 /Source="Nicolas_upshifts" /id="D1336" /incds=1 /nref=44 /ntot=61 /MaxReadThrough="0.8049" /MaxDrop="7.21386" /score="-7.46047649" /energy="-12.1" /TU="NA" /idTUdmin="U2007" /TUdmin=0 /isTUend="TRUE" CDS complement(2518969..2520471) /gene="spoIVCA" /locus_tag="BSU_25770" /old_locus_tag="BSU25770" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1631085, 2163341, 7704261, 8300549, 8969508, 8655528, 18673456" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1631085, 2163341, 7704261, 8300549, 8969508, 8655528, 18673456; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific DNA recombinase; skin element" /protein_id="NP_390454.2" /db_xref="EnsemblGenomes-Gn:BSU25770" /db_xref="EnsemblGenomes-Tr:CAB14518" /db_xref="GOA:P17867" /db_xref="InterPro:IPR006118" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR011109" /db_xref="InterPro:IPR025827" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG10458" /db_xref="UniProtKB/Swiss-Prot:P17867" /translation="MIAIYVRVSTEEQAIKGSSIDSQIEACIKKAGTKDVLKYADEGF SGELLERPALNRLREDASKGLISQVICYDPDRLSRKLMNQLIIDDELRKRNIPLIFVN GEYANSPEGQLFFAMRGAISEFEKAKIKERTSSGRLQKMKKGMIIKDSKLYGYKFVKE KRTLEILEEEAKIIRMIFNYFTDHKSPFFGRVNGIALHLTQMGVKTKKGAKVWHRQVV RQILMNSSYKGEHRQYKYDTEGSYVSKQAGNKSIIKIRPEEEQITVTIPAIVPAEQWD YAQELLGQSKRKHLSISPHNYLLSGLVRCGKCGNTMTGKKRKSHGKDYYVYTCRKNYS GAKDRGCGKEMSENKLNRHVWGEIFKFITNPQKYVSFKEAEQSNHLSDELELIEKEIE KTKKGRKRLLTLISLSDDDDLDIDEIKAQIIELQKKQNQLTEKCNEIQSKMKVLDDTS SSENALKRAIDYFQSIGADNLTLEDKKTIVNFIVKEVTIVDSDTIYIETY*" gene complement(2518969..2520471) /gene="spoIVCA" /locus_tag="BSU_25770" /old_locus_tag="BSU25770" downshifts complement(2518985) /Source="Nicolas_upshifts" /id="D1337" /incds=1 /nref=21 /ntot=131 /MaxReadThrough="2.50085" /MaxDrop="6.35891" /score="-0.144589925" /energy="-9.3" /TU="NA" /idTUdmin="U2008" /TUdmin=4 /isTUend="TRUE" promotor_-10 complement(2520578..2520596) /Source="Nicolas_upshift_promotors" /id="U2008" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1098 /SigmaFactorBS="gaaacgtttaataacactatagtttaatttaaaatctcCTCA TTtggacaaacagctgttACATAGCATTACCCAAGGGgtgatgcattttatgaaagtg a" /listShort="spoIVCA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2520596) /Source="Nicolas_upshifts" /id="U2008" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1098 /SigmaFactorBS="gaaacgtttaataacactatagtttaatttaaaatctcCTCA TTtggacaaacagctgttACATAGCATTACCCAAGGGgtgatgcattttatgaaagtg a" /listShort="spoIVCA" /GFF_Attribute="listLong" S_feature complement(2520598..2520899) /Source="Nicolas_S_feature" /locus_tag="new_2655000_2655301_c" /HighExp="dia5, Diami, S8, S7, dia15, C30, G135, S6, G180, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.974" /TUlongSig="NA" /TUlongPSig="NA" /label="S972" promotor_-35 complement(2520613..2520618) /Source="Nicolas_upshift_promotors" /id="U2008" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1098 /SigmaFactorBS="gaaacgtttaataacactatagtttaatttaaaatctcCTCA TTtggacaaacagctgttACATAGCATTACCCAAGGGgtgatgcattttatgaaagtg a" /listShort="spoIVCA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2520920..2521339) /gene="arsC" /locus_tag="BSU_25780" /old_locus_tag="BSU25780" /EC_number="1.20.4.4" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11698660, 16192272, 16905151, 8760915, 8969508, 9537360, 17303556, 21258851, 21904062, 23813734" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11698660, 16192272, 16905151, 8760915, 8969508, 9537360, 17303556, 21258851, 21904062, 23813734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thioredoxin-coupled arsenate reductase; skin element" /protein_id="NP_390455.1" /db_xref="EnsemblGenomes-Gn:BSU25780" /db_xref="EnsemblGenomes-Tr:CAB14519" /db_xref="GOA:P45947" /db_xref="InterPro:IPR014064" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:1JL3" /db_xref="PDB:1Z2D" /db_xref="PDB:1Z2E" /db_xref="PDB:2IPA" /db_xref="SubtiList:BG11304" /db_xref="UniProtKB/Swiss-Prot:P45947" /translation="MENKIIYFLCTGNSCRSQMAEGWAKQYLGDEWKVYSAGIEAHGL NPNAVKAMKEVGIDISNQTSDIIDSDILNNADLVVTLCGDAADKCPMTPPHVKREHWG FDDPARAQGTEEEKWAFFQRVRDEIGNRLKEFAETGK*" gene complement(2520920..2521339) /gene="arsC" /locus_tag="BSU_25780" /old_locus_tag="BSU25780" downshifts complement(2520944) /Source="Nicolas_upshifts" /id="D1338" /incds=0 /nref=106 /ntot=239 /MaxReadThrough="3.85143" /MaxDrop="6.98965" /score="17.1730317" /energy="-8.6" /TU="U2009" /idTUdmin="U2009" /TUdmin="-1823" /isTUend="FALSE" CDS complement(2521351..>2521479) /gene="arsB" /locus_tag="Delta6_pseudo_BSU_25790" /old_locus_tag="BSU25790" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9537360, 15849754, 16850406, 16905151; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arsenite efflux transporter; skin element" /protein_id="NP_390456.2" /db_xref="EnsemblGenomes-Gn:BSU25790" /db_xref="EnsemblGenomes-Tr:CAB14520" /db_xref="GOA:P45946" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004706" /db_xref="SubtiList:BG11303" /db_xref="UniProtKB/Swiss-Prot:P45946" /NCBI_locus_tag="A8O17_RS20905" /modified_by="User" /translation="YRIHSGAAFAAVIGPLVEVPVMIALVKVALWFQRKYFGSHSM*" /label="Delta6_pseudo_BSU_25790" gene complement(2521351..>2521479) /gene="arsB" /locus_tag="Delta6_pseudo_BSU_25790" /old_locus_tag="BSU25790" /NCBI_locus_tag="A8O17_RS20905" /modified_by="User" /label="Delta6_pseudo_BSU_25790" SCAR join(2521475,2521482) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="TFC7A" N_region 2521476..2521481 /note="EcoRV side (GATATC)" /created_by="User" /modified_by="User" /label="TFC7A" CDS <2521477..2521863 /NCBI_locus_tag="A8O17_RS12485" /NCBI_old_locus_tag="A8O17_12485" /inference="COORDINATES: similar to AA sequence:RefSeq:NP_390515.1" /note="incomplete; partial in the middle of a contig; missing N-terminus; Derived by automated computational analysis using gene prediction method: Protein Homology." /pseudo /codon_start=1 /transl_table=11 /product="ImmA/IrrE family metallo-endopeptidase" /locus_tag="Delta6_pseudo_BSU_26380" /modified_by="User" /translation="ISSFALKHSGIYNICLDSRKSRTEQWYDFAHEFCHIYRHEGDKK TMPATWTDYLDWQSNYFTYHFCIPTCMLRNINLPYIQSHAIENVAWLFKVSPSFAKKR LSIYYRKLTQHLFSQTVTGNLCPPFL*" /label="Delta6_pseudo_BSU_26380" gene <2521477..2521863 /NCBI_locus_tag="A8O17_RS12485" /NCBI_old_locus_tag="A8O17_12485" /pseudo /locus_tag="Delta6_pseudo_BSU_26380" /modified_by="User" /label="Delta6_pseudo_BSU_26380" misc_feature complement(2521830..2521848) /Source="Nicolas_upshift_promotors" /id="U2034" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.888111888111888" /psig="0.888111888111888" /xcortree=1184 /SigmaFactorBS="acgtctttttttgtttttttcaatgcgcgcaaatgcatgagg atttcattattcattacaaaaaggggggGCATAAATTTCCCGTAACAgtttgactaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 2521845..2522261 /gene="sigKc" /locus_tag="BSU_26390" /old_locus_tag="BSU26390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2163341, 7704261, 8969508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2163341, 7704261, 8969508; Product type f: factor" /pseudo /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma-K factor precursor (Sigma-27) (C-terminal fragment)" /db_xref="GOA:P12254" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="PSEUDO:CAB14580.1" /db_xref="SubtiList:BG10919" /db_xref="UniProtKB/Swiss-Prot:P12254" /translation="MPPLFVMNNEILMHLRALKKTKKDVSLHDPIGQDKEGNEISLID VLKSENEDVIDTIQLNMELEKVKQYIDILDDREKEVIVGRFGLDLKKEKTQREIAKEL GISRSYVSRIEKRALMKMFHEFYRAEKEKRKKAKGK*" gene 2521845..2522261 /gene="sigKc" /locus_tag="BSU_26390" /old_locus_tag="BSU26390" /pseudo misc_feature 2521850..2521864 /Source="Nicolas_upshift_promotors" /id="U2035" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.647352647352647" /psig="0.217782217782218" /xcortree=1060 /SigmaFactorBS="tcaacatttatttagtcaaactgttacgggaaatttatgccC CCCCTTTTTGTAATgaataatgaaatcctcatgcatttgcgcgcattgaaaaaaacaa a" /listShort="spoIIIC, S984" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2521858) /Source="Nicolas_upshifts" /id="U2034" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.888111888111888" /psig="0.888111888111888" /xcortree=1184 /SigmaFactorBS="acgtctttttttgtttttttcaatgcgcgcaaatgcatgagg atttcattattcattacaaaaaggggggGCATAAATTTCCCGTAACAgtttgactaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts 2521869 /Source="Nicolas_upshifts" /id="U2035" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.647352647352647" /psig="0.217782217782218" /xcortree=1060 /SigmaFactorBS="tcaacatttatttagtcaaactgttacgggaaatttatgccC CCCCTTTTTGTAATgaataatgaaatcctcatgcatttgcgcgcattgaaaaaaacaa a" /listShort="spoIIIC, S984" /GFF_Attribute="listLong" downshifts 2522245 /Source="Nicolas_upshifts" /id="D1357" /incds=0 /nref=50 /ntot=108 /MaxReadThrough="3.60274" /MaxDrop="5.60264" /score="-0.848064104" /energy="-4.5" /TU="U2035" /idTUdmin="U2033" /TUdmin=1 /isTUend="TRUE" CDS 2522261..2522377 /locus_tag="BSU_26399" /old_locus_tag="BSU26399" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513982.1" /translation="MQKKPDLILRLSLFERVMKIIFFIADKLSEKDRQDRNK*" gene 2522261..2522377 /locus_tag="BSU_26399" /old_locus_tag="BSU26399" S_feature 2522290..2523624 /Source="Nicolas_S_feature" /locus_tag="new_2701783_2703117" /HighExp="S8, S6, S7, S5, S4, BT, B36, dia15, C30, H2O2" /AntisenseName="psiE" /AntisenseCor="0.376363934894826" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="0.117191" /TUshortSig="Sig-" /TUshortPSig="0.218" /TUlongSig="NA" /TUlongPSig="NA" /label="S984" downshifts complement(2522408) /Source="Nicolas_upshifts" /id="D1358" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="3.25265" /MaxDrop="3.18978" /score="3.17084908" /energy="-14.7" /TU="NA" /idTUdmin="U2036" /TUdmin=66 /isTUend="FALSE" CDS complement(2522486..2522650) /gene="yrkS" /locus_tag="BSU_26400" /old_locus_tag="BSU26400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390517.1" /db_xref="EnsemblGenomes-Gn:BSU26400" /db_xref="EnsemblGenomes-Tr:CAB14581" /db_xref="SubtiList:BG11785" /db_xref="UniProtKB/Swiss-Prot:P54446" /translation="MKVIIIEGLQTDKCMNDCYHYLIKLYRQEIQGDSNISWNKRSRD RASTARSRPV*" gene complement(2522486..2522650) /gene="yrkS" /locus_tag="BSU_26400" /old_locus_tag="BSU26400" promotor_-10 complement(2522580..2522599) /Source="Nicolas_upshift_promotors" /id="U2036" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.824175824175824" /psig="0.975024975024975" /xcortree=1403 /SigmaFactorBS="aggggtgatgtattttatgaaggtaataatcatcgagggact gcaAACTGACAaatgcatgaacgatTGCTATCATTATTTAATAAAactttataggcag g" /listShort="yrkS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2522606) /Source="Nicolas_upshifts" /id="U2036" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.824175824175824" /psig="0.975024975024975" /xcortree=1403 /SigmaFactorBS="aggggtgatgtattttatgaaggtaataatcatcgagggact gcaAACTGACAaatgcatgaacgatTGCTATCATTATTTAATAAAactttataggcag g" /listShort="yrkS" /GFF_Attribute="listLong" promotor_-35 complement(2522614..2522621) /Source="Nicolas_upshift_promotors" /id="U2036" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.824175824175824" /psig="0.975024975024975" /xcortree=1403 /SigmaFactorBS="aggggtgatgtattttatgaaggtaataatcatcgagggact gcaAACTGACAaatgcatgaacgatTGCTATCATTATTTAATAAAactttataggcag g" /listShort="yrkS" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2522784) /Source="Nicolas_upshifts" /id="D1359" /incds=0 /nref=79 /ntot=219 /MaxReadThrough="1.20909" /MaxDrop="4.40328" /score="39.3560776" /energy="-10.6" /TU="NA" /idTUdmin="U2036" /TUdmin="-310" /isTUend="FALSE" CDS complement(2523195..2523611) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12897016, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="phosphate starvation inducible protein" /protein_id="NP_390518.2" /db_xref="EnsemblGenomes-Gn:BSU26410" /db_xref="EnsemblGenomes-Tr:CAB14582" /db_xref="GOA:P54445" /db_xref="InterPro:IPR009315" /db_xref="InterPro:IPR020948" /db_xref="SubtiList:BG11784" /db_xref="UniProtKB/Swiss-Prot:P54445" /translation="MRFSNKFKKVPYLLQALLNVCLFFLALALSALLISETWYIVLFV YKSLFNKVDSYYEMLGELLIFFMYFEFIALIIKYFKSDFHFPLRYFIYIGITAVIRLI IIDHDQAISTFWWAMAILAMICGFFIANRRNSVVEH*" gene complement(2523195..2523611) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" CDS complement(2523657..2524955) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YrkP]" /protein_id="NP_390519.1" /db_xref="EnsemblGenomes-Gn:BSU26420" /db_xref="EnsemblGenomes-Tr:CAB14583" /db_xref="GOA:P54444" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11783" /db_xref="UniProtKB/Swiss-Prot:P54444" /translation="MAHLKFTLTKKLALLIMVAAIVSGVIFLTLQKITDDLIEGYLSS EEYYHEESARYIQKFSKYVSENELSTSDRKAFGEWVKKENYINLTIFKDQELQYDSIY SESDYGKEKLTQYAQNHSHPVKFSDGEGRVIIDGFYSSRYYDLAFALDLLGATLIFLI IVLFGIRQSLRYLKTIHQEIHILEGGELDYEMTIKGHDELAMIAKSIEDLRKAFLDKL KAIEELQAESRSLVTEMSHDMRTPLTSLIMNLEFAKKEGGEAGASKDRYVANAYGKAL QLKSLSDNLFAYFLLNKEYEADLETVAVKEVIYDLISDQIAILHQEHFRVHISGELPE TYINVNLEELGRVFDNVMSNLLKYADPEEKISITFVSDQEIFEIHVSNTIKLADITPE SNGLGERSIARMMSRMQGQFHSIQKNSKYYIVLRFWNTKM*" gene complement(2523657..2524955) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" CDS complement(2524942..2525637) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18175906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18175906; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YrkQ]" /protein_id="NP_390520.1" /db_xref="EnsemblGenomes-Gn:BSU26430" /db_xref="EnsemblGenomes-Tr:CAB14584" /db_xref="GOA:P54443" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11782" /db_xref="UniProtKB/Swiss-Prot:P54443" /translation="MAYRILVVEDDEDIGDLLEESLTRAGYEVLRAKDGKRALQLVND SLDLVILDIMMPGISGIETCQHIRKSSNVPILFLTARSSTLDKTEGLLAGGDDYMTKP FSEEELHARVIAQLRRYTIYQEKKEQEETFLIGGKLRVSEEFNEVWKEEKQIKLSDLE YRILKLLMNKRNKIFSAQNIYESVWGQPYFYCSNNTVMVHIRKLRSKIEDDPARPVYI KTEWGRGYRFGAS*" gene complement(2524942..2525637) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" misc_feature complement(2525703..2525720) /Source="Nicolas_upshift_promotors" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2525712) /Source="Nicolas_upshifts" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" promotor_-35 2525798..2525804 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2525811..2525829 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2525826 /Source="Nicolas_upshifts" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 2525905..2527122 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390521.1" /db_xref="EnsemblGenomes-Gn:BSU26440" /db_xref="EnsemblGenomes-Tr:CAB14585" /db_xref="GOA:P54442" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11781" /db_xref="UniProtKB/Swiss-Prot:P54442" /translation="MIVQKEGRGQPVSLRERVHFLDIVRGFALLGIIIVNYFLIVDSV KGFEMASDDVLHKLVSWFAEGKFVTLFSFLFGVGFMIFMDRAAQKVESPNKLFARRLS ILLGFGILHITFVWVGDILAFYAVSGFLLLAFYKRTAKTVLRWIIALIVFQFLTPVFT MLYNVINTAGSKNPNFSEFTLFSHSSLTYMESISTRWTDMVTMAAGSFSMIYSMFLMF LLGVYFVKMEFFKDMEAKKPIWKRIWIISTIAFLITQSSILLDMFNLSENMLWKDISS VLGQNGGLTGSMFYMSTFAMLFLYLPQLRGPMMIFTKVGRMSLTCYLLHSIIGTVLFL RYGFGLADHIQSAGTFMFSLAVYFVLMSFSTLWLKRFRYGPMELVWRKLTYGKVNGSP KATPLHSEKSIQK*" gene 2525905..2527122 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" promotor_-35 2526364..2526371 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2526386..2526405 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2526402 /Source="Nicolas_upshifts" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 2527041..2527289 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513983.1" /translation="MAQADVRQSKRESQSNSAAFGKIYSEITPLHRLHDFKLVLLNEA GIKRTDLIYGLVIFISFRLLWANKSTRVYSMCIAHDRI*" gene 2527041..2527289 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" S_feature complement(2527218..2528265) /Source="Nicolas_S_feature" /locus_tag="new_2706711_2707758_c" /HighExp="Diami, C30, dia15, dia5, Lbstat, S8, C90, G180, H2O2, G135" /AntisenseName="yrkN" /AntisenseCor="0.40539464433869998" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S985" CDS 2527634..2528191 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" /EC_number="2.3.-.-" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390522.1" /db_xref="EnsemblGenomes-Gn:BSU26450" /db_xref="EnsemblGenomes-Tr:CAB14586" /db_xref="GOA:P54441" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11780" /db_xref="UniProtKB/Swiss-Prot:P54441" /translation="MKTKNEPKVILELAKESDLPEFQKKLQEAFAIAVIETFGDCEDG PIPSDNDVQESFNAPGAVVYHILQDGKNVGGAVVRINSQTNHNSLDLFYVSPEYHSQG IGLSAWKAIEAQYPDTVLWETVTPYFEKRNINFYVNKCGFHIVEFYNEHHSNPHMHRN GREDDKPLLNDDDFFRFVKIMKKKD*" gene 2527634..2528191 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" S_feature 2528192..2528314 /Source="Nicolas_S_feature" /locus_tag="new_2707685_2707807" /HighExp="S8, Sw, C30, S7, BC, C90, Lbstat, Mal, LoTm, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S986" S_feature complement(2528267..2528681) /Source="Nicolas_S_feature" /locus_tag="new_2707760_2708174_c" /HighExp="M0t90, M40t90, Lbstat, dia5, LPhT, dia15, M9-stat, Lbtran, C90, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S987" downshifts complement(2528310) /Source="Nicolas_upshifts" /id="D1360" /incds=0 /nref=81 /ntot=255 /MaxReadThrough="5.45539" /MaxDrop="5.6563" /score="-3.35079978" /energy="-23.7" /TU="U2041,U2042,U2044,U2045" /idTUdmin="U2042" /TUdmin="-182" /isTUend="FALSE" CDS complement(2528682..2529206) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" /EC_number="1.6.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase" /protein_id="NP_390524.2" /db_xref="EnsemblGenomes-Gn:BSU26470" /db_xref="EnsemblGenomes-Tr:CAB14588" /db_xref="GOA:P54439" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11778" /db_xref="UniProtKB/Swiss-Prot:P54439" /translation="MKTLVIVIHPNLETSVVNKTWMNRLKQEKDITVHDLYGEYPNFI IDVEKEQQLLLDHERIVFQFPMYWYSSPALLKQWEDDVLTHGWAYGTGGTKLHGKELL LAISLGAQESDYQAGGEYNITISELIRPFQVTANYIGMRFLPAFTQYGTLHLSKEDVK NSAERLVDYLKAEH*" gene complement(2528682..2529206) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" promotor_-35 2529054..2529061 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2529072..2529091 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2529086 /Source="Nicolas_upshifts" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2529207..2529294) /Source="Nicolas_S_feature" /locus_tag="new_2708700_2708787_c" /HighExp="dia5, Etha, dia15, M9-stat, M0t90, Lbtran, Diami, C90, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S988" promotor_-10 complement(2529289..2529308) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2529294) /Source="Nicolas_upshifts" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" S_feature complement(2529296..2529449) /Source="Nicolas_S_feature" /locus_tag="new_2708789_2708942_c" /HighExp="M0t90, M9-stat, Lbstat, M40t90, T1.30H, C90, Lbtran, T0.30H, dia15, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S989" promotor_-35 complement(2529323..2529330) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2529450..2529926) /gene="yrkK" /locus_tag="BSU_26480" /old_locus_tag="BSU26480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390525.2" /db_xref="EnsemblGenomes-Gn:BSU26480" /db_xref="EnsemblGenomes-Tr:CAB14589" /db_xref="GOA:P54438" /db_xref="InterPro:IPR025671" /db_xref="SubtiList:BG11777" /db_xref="UniProtKB/Swiss-Prot:P54438" /translation="MVYFVAFFCFAITLHNIEEAIWLPEWSQQSSKFQKPVTSNEFHF AVIVITMLAYLSAFGFLYMPESDIAKWIFIGFLGSMVINAIFPHLIATVVMKKYAPGL LTGLLLNIPVNSLVIYQMFLKNLIVWKELIISTLVVGIILLALIPLLFKVGDKVSP*" gene complement(2529450..2529926) /gene="yrkK" /locus_tag="BSU_26480" /old_locus_tag="BSU26480" promotor_-10 complement(2529962..2529981) /Source="Nicolas_upshift_promotors" /id="U2042" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig="0.962037962037962" /xcortree=3147 /SigmaFactorBS="caactactaaggcagattcttctctcttttaacaCCATATCC aatcagcctcaaaTGTAATATAATGTTGCCAAAccatattggttgtggcaccgaggag g" /listShort="yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2529976) /Source="Nicolas_upshifts" /id="U2042" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig="0.962037962037962" /xcortree=3147 /SigmaFactorBS="caactactaaggcagattcttctctcttttaacaCCATATCC aatcagcctcaaaTGTAATATAATGTTGCCAAAccatattggttgtggcaccgaggag g" /listShort="yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" S_feature complement(2529978..2530508) /Source="Nicolas_S_feature" /locus_tag="new_2709471_2710001_c" /HighExp="Diami, dia15, S8, G180, Etha, G135, S6, S0, G150, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S990" promotor_-35 complement(2529995..2530002) /Source="Nicolas_upshift_promotors" /id="U2042" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig="0.962037962037962" /xcortree=3147 /SigmaFactorBS="caactactaaggcagattcttctctcttttaacaCCATATCC aatcagcctcaaaTGTAATATAATGTTGCCAAAccatattggttgtggcaccgaggag g" /listShort="yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2530509..2531294) /gene="yrkJ" /locus_tag="BSU_26490" /old_locus_tag="BSU26490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_390526.1" /db_xref="EnsemblGenomes-Gn:BSU26490" /db_xref="EnsemblGenomes-Tr:CAB14590" /db_xref="GOA:P54437" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG11776" /db_xref="UniProtKB/Swiss-Prot:P54437" /translation="MDIAFITTLFIIGFIGAFISGMIGIGGAVINYPMLLYIPSLVGV MSLTAHEVSGIGAIQVFFATLGGVWAYRKSGLINKTLIIYMGSSILLGSVLGSYFSHY ISEKGINFIYGILAIIAVILMFIPKKGQKGQEHSEDKEVIFNKWLASSLAFIIGGVSG ILGAGGAFILVPIMLSILNIPVRVTVASSLAITFLSSIGATVGKVITGQVLFVPALVL MITSLIASPIGASVGQKVNTKFLQWVLAQLIGATAIKIWLELL*" gene complement(2530509..2531294) /gene="yrkJ" /locus_tag="BSU_26490" /old_locus_tag="BSU26490" CDS complement(2531355..2531582) /gene="yrkI" /locus_tag="BSU_26500" /old_locus_tag="BSU26500" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9555915; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative sulfur-carrier protein" /protein_id="NP_390527.1" /db_xref="EnsemblGenomes-Gn:BSU26500" /db_xref="EnsemblGenomes-Tr:CAB14591" /db_xref="GOA:P54436" /db_xref="InterPro:IPR001455" /db_xref="InterPro:IPR036868" /db_xref="SubtiList:BG11775" /db_xref="UniProtKB/Swiss-Prot:P54436" /translation="MKSDKVLDAKGLACPMPIVRTKKAMNELESGQILEVHATDKGAK NDLTAWSKSGGHDLLEQTDEGDILKFWIQKG*" gene complement(2531355..2531582) /gene="yrkI" /locus_tag="BSU_26500" /old_locus_tag="BSU26500" downshifts complement(2531379) /Source="Nicolas_upshifts" /id="D1361" /incds=0 /nref=4 /ntot=22 /MaxReadThrough="5.31659" /MaxDrop="3.95633" /score="-3.35079978" /energy="-23.7" /TU="U2044,U2045" /idTUdmin="U2046" /TUdmin=3085 /isTUend="FALSE" CDS complement(2531616..2532749) /gene="yrkH" /locus_tag="BSU_26510" /old_locus_tag="BSU26510" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase / hydrolase" /protein_id="NP_390528.2" /db_xref="EnsemblGenomes-Gn:BSU26510" /db_xref="EnsemblGenomes-Tr:CAB14592" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036866" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG11774" /db_xref="UniProtKB/Swiss-Prot:P54435" /translation="MKHDRKGNDPKRSDKKIFNKEPLFILDVRNENDFSDWKIEGHDF DHLNVPYFDLLDGVEDILEKIPSDKEVLVVCAKEGSSVMVSEMLSEAGHSVSYLKGGM KAWSEHLEPVKVGDLKDGGEMYQFVRIGKGCLSYMVISNGEAAIIDATRMVNFFIDFA KGKGATITHVFDTHLHADHISGGRVIAEKTKATYWLPPKDAEEVEFDYQPLEEGNDII IGNTTIKIQPIYSPGHTIGSTSFIVDDQYLLSGDILFIDSIGRPDLAGMAEDWVGDLR KTLYSRYKALSKDLIVLPAHFMIIDELNENGSVGKQLSTLFSENHGLNIADETEFRHL VTDHLPPQPNAYQEIRETNMGKISPDEEKQREMEIGPNRCAIR*" gene complement(2531616..2532749) /gene="yrkH" /locus_tag="BSU_26510" /old_locus_tag="BSU26510" misc_feature complement(2532451..2532466) /Source="Nicolas_upshift_promotors" /id="U2043" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.410589410589411" /psig="0.477522477522478" /xcortree=1482 /SigmaFactorBS="aaaagaaggttcatccgtcatggtatccgaaatgctttctga agcaggtcattctgTATCCTACCTTAAGGGtggaatgaaagcatggagcgaacattta g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2532462) /Source="Nicolas_upshifts" /id="U2043" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.410589410589411" /psig="0.477522477522478" /xcortree=1482 /SigmaFactorBS="aaaagaaggttcatccgtcatggtatccgaaatgctttctga agcaggtcattctgTATCCTACCTTAAGGGtggaatgaaagcatggagcgaacattta g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2532750..2533083) /Source="Nicolas_S_feature" /locus_tag="new_2712243_2712576_c" /HighExp="Diami, dia15, Sw, BC, S0, G180, dia5, G135, M9-stat, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99950300000000003" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S991" CDS complement(2533084..2533641) /gene="yrkF" /locus_tag="BSU_26530" /old_locus_tag="BSU26530" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative rhodanese-related sulfur transferase" /protein_id="NP_390530.1" /db_xref="EnsemblGenomes-Gn:BSU26530" /db_xref="EnsemblGenomes-Tr:CAB14594" /db_xref="InterPro:IPR001455" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036868" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG11772" /db_xref="UniProtKB/Swiss-Prot:P54433" /translation="MMKATIVLDAKGLACPMPIVKTKKRMKDLKAGEVLEIHATDKGS TADLEAWAKSTGHEYLGTEAEGEILRHFLRKGGEHSSENASSIPEISLEAFKQKVDSD ESLNILDVREIEEYEKAHIPGVVHIPLGEVEKRANELNENDEIYIICHSGRRSEMAAR TMKKQGFKKVINVVPGMRDWTGKTE*" gene complement(2533084..2533641) /gene="yrkF" /locus_tag="BSU_26530" /old_locus_tag="BSU26530" S_feature complement(2533642..2533826) /Source="Nicolas_S_feature" /locus_tag="new_2713135_2713319_c" /HighExp="Diami, dia15, Sw, BC, S8, dia5, G180, S7, S0, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.12629799999999999" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S992" CDS complement(2533827..2534309) /gene="yrkE" /locus_tag="BSU_26540" /old_locus_tag="BSU26540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative protein involved in sulfur metabolism (DsrE-like)" /protein_id="NP_390531.1" /db_xref="EnsemblGenomes-Gn:BSU26540" /db_xref="EnsemblGenomes-Tr:CAB14595" /db_xref="InterPro:IPR027396" /db_xref="InterPro:IPR032836" /db_xref="SubtiList:BG11771" /db_xref="UniProtKB/Swiss-Prot:P54432" /translation="MTEQTKRTTIVLFSGDYDKAMAAYIIANGAAAYDHEVTIFHTFW GFNALRKEELIPVKKGFLEKMFGKMMPRGADKMGLSKMNFAGMGPKMIKNVMKKHNVL TLPQLIEMAQEQGVKLVACTMTMDLLGLQEKELLDDIDYAGVAAYLADAEEGSVNLFI *" gene complement(2533827..2534309) /gene="yrkE" /locus_tag="BSU_26540" /old_locus_tag="BSU26540" S_feature complement(2534310..2534418) /Source="Nicolas_S_feature" /locus_tag="new_2713803_2713911_c" /HighExp="Diami, dia15, Sw, BC, dia5, S8, G180, S6, Oxctl, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S993" CDS complement(2534456..2534647) /gene="yrkD" /locus_tag="BSU_26550" /old_locus_tag="BSU26550" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21339296; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative metal-sensitive transcriptional regulator involved in sulfur metabolism" /protein_id="NP_390532.1" /db_xref="EnsemblGenomes-Gn:BSU26550" /db_xref="EnsemblGenomes-Tr:CAB14596" /db_xref="GOA:P54431" /db_xref="InterPro:IPR003735" /db_xref="SubtiList:BG11770" /db_xref="UniProtKB/Swiss-Prot:P54431" /translation="MMEQGKDCREVVTQLAASRNAIDRAMGLIVSTNLEHCVRESLEK GEDTQNLVKEAVDLLVKSR*" gene complement(2534456..2534647) /gene="yrkD" /locus_tag="BSU_26550" /old_locus_tag="BSU26550" downshifts complement(2534463) /Source="Nicolas_upshifts" /id="D1362" /incds=0 /nref=153 /ntot=252 /MaxReadThrough="8.17686" /MaxDrop="5.42995" /score="-6.39526496" /energy="-7.9" /TU="U2044,U2045" /idTUdmin="U2046" /TUdmin=1 /isTUend="TRUE" S_feature complement(2534648..2534737) /Source="Nicolas_S_feature" /locus_tag="new_2714141_2714230_c" /HighExp="Diami, dia15, S6, S7, S8, Etha, dia5, S5, BC, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigK" /TUshortPSig="1, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S994" CDS complement(2534738..2535055) /gene="yrzM" /locus_tag="BSU_26558" /old_locus_tag="BSU26558" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /db_xref="PSEUDO:CAX52666.1" /translation="MIIIATYRRYYPITGISCIHKDKLEAMDITILDIRHYNDVANFS DNIILNIPYAYLKRFYLEIPRDKIHIIARDRVELNLGVRFLKRKGIHVNSYELATCKC KNK*" gene complement(2534738..2535055) /gene="yrzM" /locus_tag="BSU_26558" /old_locus_tag="BSU26558" /pseudo promotor_-10 complement(2534844..2534863) /Source="Nicolas_upshift_promotors" /id="U2044" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=1899 /SigmaFactorBS="aatattattttaaacatcccatatgcgtatctaaaacgTTTT TATttagagattccaCGTGATAAAATACACATAATagctcgtgaccgggtggaattaa a" /listShort="S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2534860) /Source="Nicolas_upshifts" /id="U2044" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=1899 /SigmaFactorBS="aatattattttaaacatcccatatgcgtatctaaaacgTTTT TATttagagattccaCGTGATAAAATACACATAATagctcgtgaccgggtggaattaa a" /listShort="S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" promotor_-35 complement(2534876..2534882) /Source="Nicolas_upshift_promotors" /id="U2044" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=1899 /SigmaFactorBS="aatattattttaaacatcccatatgcgtatctaaaacgTTTT TATttagagattccaCGTGATAAAATACACATAATagctcgtgaccgggtggaattaa a" /listShort="S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2535097..2535312) /gene="yrzN" /locus_tag="BSU_26559" /old_locus_tag="BSU26559" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52667.1" /translation="MINKADLKLNRLIALFEFLLAELALSNVSIFSIRGYRNESISSK KVTFTLDYIPMGVYYCFVNKQRVNKVV*" gene complement(2535097..2535312) /gene="yrzN" /locus_tag="BSU_26559" /old_locus_tag="BSU26559" /pseudo promotor_-10 complement(2535125..2535144) /Source="Nicolas_upshift_promotors" /id="U2045" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.728271728271728" /psig="0.998001998001998" /xcortree=1794 /SigmaFactorBS="tgaatctatcagctcaaagaaagtaactttcacACTTGACTa tatacctatggggGTATATTATTGTTTTGTGAAtaaacaaagagttaataaggtggtg t" /listShort="yrzM, S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2535139) /Source="Nicolas_upshifts" /id="U2045" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.728271728271728" /psig="0.998001998001998" /xcortree=1794 /SigmaFactorBS="tgaatctatcagctcaaagaaagtaactttcacACTTGACTa tatacctatggggGTATATTATTGTTTTGTGAAtaaacaaagagttaataaggtggtg t" /listShort="yrzM, S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" promotor_-35 complement(2535159..2535166) /Source="Nicolas_upshift_promotors" /id="U2045" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.728271728271728" /psig="0.998001998001998" /xcortree=1794 /SigmaFactorBS="tgaatctatcagctcaaagaaagtaactttcacACTTGACTa tatacctatggggGTATATTATTGTTTTGTGAAtaaacaaagagttaataaggtggtg t" /listShort="yrzM, S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2535313..2535439) /Source="Nicolas_S_feature" /locus_tag="new_2714806_2714932_c" /HighExp="S6, S7, S8, S5, BT, B36, G/S, BC, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.114547" /TUshortSig="SigK, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S995" CDS complement(2535440..2536000) /gene="yrkC" /locus_tag="BSU_26560" /old_locus_tag="BSU26560" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme; cupin family" /protein_id="NP_390533.1" /db_xref="EnsemblGenomes-Gn:BSU26560" /db_xref="EnsemblGenomes-Tr:CAB14597" /db_xref="GOA:P54430" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG11769" /db_xref="UniProtKB/Swiss-Prot:P54430" /translation="MYYNPFSPQCYYYVTVPMYNDGRSVYWTIPNEMEKVHRGADLRS SYEDRNLLLKDYGPKPFVVNINRATKQNNTFRTALWTGKHFQVTLMSLGIGEDIGLEI HPNVDQFLRIEQGRGIVKMGKSKDHLNFQRNVYDDSAIVVPAGTWHNVINTGNTPLKL YSIYAPPNHPFGTVHETKADAVAAED*" gene complement(2535440..2536000) /gene="yrkC" /locus_tag="BSU_26560" /old_locus_tag="BSU26560" CDS complement(2536017..2536193) /locus_tag="BSU_26569" /old_locus_tag="BSU26569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513984.1" /translation="MLTKASEIQHLENDYKVGDKLFIHESNGDRTFIFVFNMSFLDLA HSLNKCIGYYHKNL*" gene complement(2536017..2536193) /locus_tag="BSU_26569" /old_locus_tag="BSU26569" promotor_-10 complement(2536027..2536046) /Source="Nicolas_upshift_promotors" /id="U2046" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1282 /SigmaFactorBS="catttttgtgtttaatatgagttttcttgaTTTAGCACACtc ccttaataaaTGCATAGGATACTATCACAAaaatttataattgcggggatcaaaaaat g" /listShort="yrkC, S995, yrzN, yrzM, S994, yrkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2536038) /Source="Nicolas_upshifts" /id="U2046" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1282 /SigmaFactorBS="catttttgtgtttaatatgagttttcttgaTTTAGCACACtc ccttaataaaTGCATAGGATACTATCACAAaaatttataattgcggggatcaaaaaat g" /listShort="yrkC, S995, yrzN, yrzM, S994, yrkD" /GFF_Attribute="listLong" S_feature complement(2536040..2536225) /Source="Nicolas_S_feature" /locus_tag="new_2715533_2715718_c" /HighExp="BC, Sw, S3, dia15, Etha, S4, S5, H2O2, LBGtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.49093999999999999" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S996" promotor_-35 complement(2536059..2536068) /Source="Nicolas_upshift_promotors" /id="U2046" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1282 /SigmaFactorBS="catttttgtgtttaatatgagttttcttgaTTTAGCACACtc ccttaataaaTGCATAGGATACTATCACAAaaatttataattgcggggatcaaaaaat g" /listShort="yrkC, S995, yrzN, yrzM, S994, yrkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2536226..2536372) /gene="yrkB" /locus_tag="BSU_26570" /old_locus_tag="BSU26570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390534.1" /db_xref="EnsemblGenomes-Gn:BSU26570" /db_xref="EnsemblGenomes-Tr:CAB14598" /db_xref="SubtiList:BG11768" /db_xref="UniProtKB/Swiss-Prot:P54429" /translation="MLLKNWPSRRIQRDKSKRAGIGGTNNRIPYTLLLCYVNVQKPFR IVDL*" gene complement(2536226..2536372) /gene="yrkB" /locus_tag="BSU_26570" /old_locus_tag="BSU26570" CDS complement(2536542..2537363) /gene="bltR" /locus_tag="BSU_26580" /old_locus_tag="BSU26580" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7608059, 9083003, 10200972, 21954605" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7608059, 9083003, 10200972, 21954605; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (polyamine metabolism)" /protein_id="NP_390535.1" /db_xref="EnsemblGenomes-Gn:BSU26580" /db_xref="EnsemblGenomes-Tr:CAB14599" /db_xref="GOA:P39842" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR011256" /db_xref="SubtiList:BG10904" /db_xref="UniProtKB/Swiss-Prot:P39842" /translation="MSEDVKKYFTTGEFSKLCRVKKQTLFHYDEIGLFSPEIKKENGY RYYSYHQFETFQVISLFKELGVPLKEIKCLIKGKTPDKILHVLKEKSIEIDKKINELK QLQTILQTKVTLTEQALETDFSSISFEYLNEETFMLSRKTLNLPERKYVAAISELIHE VQQYELDEGYPIGGIFAREQILEKDFYNYSYFYIKVKDGAENINYHVRPKGLYAVGYE IGGNTEEAYRRIIEFIERNGMQIGENAYEEYMLDEMVVDGYENTYAKILLQVKEV*" gene complement(2536542..2537363) /gene="bltR" /locus_tag="BSU_26580" /old_locus_tag="BSU26580" promotor_-35 2537371..2537378 /Source="Nicolas_upshift_promotors" /id="U2048" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.997002997002997" /xcortree=1531 /SigmaFactorBS="acttcttaacatcttcgctcataaaaaccTCCTTGACtatac ggtaaccataTACCTTATGATTTGATTGTActtgaaaaaagcttcaagcgaaaaggat a" /listShort="blt" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2537373..2537392) /Source="Nicolas_upshift_promotors" /id="U2047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.966033966033966" /xcortree=1901 /SigmaFactorBS="tttttacctatccttttcgcttgaagcttttttcaagtacaa tcaaatcataaggtatATGGTTACCGTATAGTCAAGgaggtttttatgagcgaagatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2537390) /Source="Nicolas_upshifts" /id="U2047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.966033966033966" /xcortree=1901 /SigmaFactorBS="tttttacctatccttttcgcttgaagcttttttcaagtacaa tcaaatcataaggtatATGGTTACCGTATAGTCAAGgaggtttttatgagcgaagatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2537392..2539396) /Source="Nicolas_S_feature" /locus_tag="new_2716885_2718889_c" /HighExp="BC, Sw, Salt, Mal, T4.0H, M9-stat, T3.30H, G180, G135, MG 5" /AntisenseName="blt" /AntisenseCor="0.56943492854420497" /AntisenseRegPval="-23.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S997" promotor_-10 2537394..2537413 /Source="Nicolas_upshift_promotors" /id="U2048" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.997002997002997" /xcortree=1531 /SigmaFactorBS="acttcttaacatcttcgctcataaaaaccTCCTTGACtatac ggtaaccataTACCTTATGATTTGATTGTActtgaaaaaagcttcaagcgaaaaggat a" /listShort="blt" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2537402 /Source="Nicolas_upshifts" /id="U2048" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.997002997002997" /xcortree=1531 /SigmaFactorBS="acttcttaacatcttcgctcataaaaaccTCCTTGACtatac ggtaaccataTACCTTATGATTTGATTGTActtgaaaaaagcttcaagcgaaaaggat a" /listShort="blt" /GFF_Attribute="listLong" CDS 2537480..2538682 /gene="blt" /locus_tag="BSU_26590" /old_locus_tag="BSU26590" /function="16.1: Circulate" /function="16.4: Excrete" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9083003, 10200972, 10359661, 12793527, 15849754, 16850406, 19114526, 21954605" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9083003, 10200972, 10359661, 12793527, 15849754, 16850406, 19114526, 21954605; Product type t: transporter" /codon_start=1 /transl_table=11 /product="efflux transporter (promiscuous, acetylated polyamines efflux)" /protein_id="NP_390536.1" /db_xref="EnsemblGenomes-Gn:BSU26590" /db_xref="EnsemblGenomes-Tr:CAB14600" /db_xref="GOA:P39843" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR004734" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10905" /db_xref="UniProtKB/Swiss-Prot:P39843" /translation="MKKSINEQKTIFIILLSNIFVAFLGIGLIIPVMPSFMKIMHLSG STMGYLVAAFAISQLITSPFAGRWVDRFGRKKMIILGLLIFSLSELIFGLGTHVSIFY FSRILGGVSAAFIMPAVTAYVADITTLKERSKAMGYVSAAISTGFIIGPGAGGFIAGF GIRMPFFFASAIALIAAVTSVFILKESLSIEERHQLSSHTKESNFIKDLKRSIHPVYF IAFIIVFVMAFGLSAYETVFSLFSDHKFGFTPKDIAAIITISSIVAVVIQVLLFGKLV NKLGEKRMIQLCLITGAILAFVSTVMSGFLTVLLVTCFIFLAFDLLRPALTAHLSNMA GNQQGFVAGMNSTYTSLGNIFGPALGGILFDLNIHYPFLFAGFVMIVGLGLTMVWKEK KNDAAALN*" gene 2537480..2538682 /gene="blt" /locus_tag="BSU_26590" /old_locus_tag="BSU26590" CDS 2538851..2539309 /gene="bltD" /locus_tag="BSU_26600" /old_locus_tag="BSU26600" /EC_number="2.3.1.57" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10200972, 10359661, 12793527, 9083003, 16210326, 21954605, 28197687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 10359661, 12793527, 9083003, 16210326, 21954605, 28197687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spermine/spermidine acetyltransferase" /protein_id="NP_390537.1" /db_xref="EnsemblGenomes-Gn:BSU26600" /db_xref="EnsemblGenomes-Tr:CAB14601" /db_xref="GOA:P39909" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR027455" /db_xref="SubtiList:BG10906" /db_xref="UniProtKB/Swiss-Prot:P39909" /translation="MSINIKAVTDDNRAAILDLHVSQNQLSYIESTKVCLEDAKECHY YKPVGLYYEGDLVGFAMYGLFPEYDEDNKNGRVWLDRFFIDERYQGKGLGKKMLKALI QHLAELYKCKRIYLSIFENNIHAIRLYQRFGFQFNGELDFNGEKVMVKEL*" gene 2538851..2539309 /gene="bltD" /locus_tag="BSU_26600" /old_locus_tag="BSU26600" downshifts complement(2539441) /Source="Nicolas_upshifts" /id="D1363" /incds=0 /nref=77 /ntot=211 /MaxReadThrough="5.09534" /MaxDrop="4.8114" /score="-0.00168005652" /energy="-10.7" /TU="U2049" /idTUdmin="U2051" /TUdmin=3845 /isTUend="FALSE" CDS complement(2539466..2540770) /gene="yrkA" /locus_tag="BSU_26610" /old_locus_tag="BSU26610" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative membrane associated protein" /protein_id="NP_390538.1" /db_xref="EnsemblGenomes-Gn:BSU26610" /db_xref="EnsemblGenomes-Tr:CAB14602" /db_xref="GOA:P54428" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG11767" /db_xref="UniProtKB/Swiss-Prot:P54428" /translation="MTTINLIIFTLLIVLTAFFVATEFAIVKIRSSKIDQLILEGKKG AISAKKVITHLDEYLSACQLGITVTALGIGWVGESTFEVILHPLFAHFHVSETVSHVL ILVIAFVMATFLHVVVGELAPKTLAIQKAETITLLTAKPIIWFYRILFPFIWFLNGSA RFIVGLFGLKPASEHELAHSEEELRILLSESYKSGEINQNELKYVNNIFEFDERIAKE IMIPRREIVAISSEDSYETIVKIIKTESYTRYPVLNGDKDSIIGFINAKEFLSAYIDT DQKIKEDFKLENHINPVIHVIESVPIHDVLVKMQKERTHIAILVDEYGGTSGLVTAED ILEEIVGEIRDEFDKDEVPNIRKVNDNHYILDSKVLIEDVNDLLGTTLASDEVDTIGG WFMTQQIDAAVGSVIEADGYIFKVHETVGRHINYLEIVRKKE*" gene complement(2539466..2540770) /gene="yrkA" /locus_tag="BSU_26610" /old_locus_tag="BSU26610" S_feature complement(2540771..2540850) /Source="Nicolas_S_feature" /locus_tag="new_2720264_2720343_c" /HighExp="BC, Sw, MG 15, Mal, Salt, MG 25, MG-0.2, MG 45, MG 5, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S998" promotor_-10 complement(2540836..2540855) /Source="Nicolas_upshift_promotors" /id="U2049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1760 /SigmaFactorBS="atacggaaaaagatgattatttacatcattcagAGTTGATTt taggttcttttgaACTTATAATGTTATATATACtgttttttgtttattcaataaatat t" /listShort="S998, yrkA, S997, bltR, yrkB, S996, yrkC, S995" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2540850) /Source="Nicolas_upshifts" /id="U2049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1760 /SigmaFactorBS="atacggaaaaagatgattatttacatcattcagAGTTGATTt taggttcttttgaACTTATAATGTTATATATACtgttttttgtttattcaataaatat t" /listShort="S998, yrkA, S997, bltR, yrkB, S996, yrkC, S995" /GFF_Attribute="listLong" promotor_-35 complement(2540870..2540877) /Source="Nicolas_upshift_promotors" /id="U2049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1760 /SigmaFactorBS="atacggaaaaagatgattatttacatcattcagAGTTGATTt taggttcttttgaACTTATAATGTTATATATACtgttttttgtttattcaataaatat t" /listShort="S998, yrkA, S997, bltR, yrkB, S996, yrkC, S995" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2541033..2541176) /gene="yrzO" /locus_tag="BSU_26619" /old_locus_tag="BSU26619" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097765.1" /db_xref="EnsemblGenomes-Gn:BSU26619" /db_xref="EnsemblGenomes-Tr:CAX52668" /db_xref="InterPro:IPR025417" /db_xref="UniProtKB/Swiss-Prot:C0H458" /translation="MFEGLLFFISAGIVCELAAINRNGRKNIKQQAELIQILKENLYK DIK*" gene complement(2541033..2541176) /gene="yrzO" /locus_tag="BSU_26619" /old_locus_tag="BSU26619" CDS complement(2541194..2542159) /gene="yrdR" /locus_tag="BSU_26620" /old_locus_tag="BSU26620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390539.1" /db_xref="EnsemblGenomes-Gn:BSU26620" /db_xref="EnsemblGenomes-Tr:CAB14603" /db_xref="GOA:O07086" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12289" /db_xref="UniProtKB/Swiss-Prot:O07086" /translation="MKKGQLFIGALTCLVASMSWGAMFPVADHALEFVDPFYFSFIRY GVVTIMLVILLLVREGKKSFHLEGKAKWIILFGVMAFTIYNVLIFLGQRLMGKSGIMT ASIAEALMPMLSIVILWGYKHVKPKKYTMISILIAFLGASMVITKGNISFFFSLGDHL FSILFIFIGVLGWVVYTMGGQIFREWSTLRYSTLTCLFGTAITGIMTAILTAQGYVSV PSIKVIAAIKYDFLFMITLPGIIALLSWNYGIKILSSINGILFINFVPITTLLIMVIK GYNITAFDIVGTLFVIIGLILNNIYQRKEDYKQVLQKEKTNLTIT*" gene complement(2541194..2542159) /gene="yrdR" /locus_tag="BSU_26620" /old_locus_tag="BSU26620" promotor_-35 2542197..2542200 /Source="Nicolas_upshift_promotors" /id="U2050" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.601398601398601" /psig="0.905094905094905" /xcortree=1788 /SigmaFactorBS="aaattacaatgagaaTTATaaaaagaagtaagcATCAAGTAA AATGAACAAAAgtgatgaaaaacatcattgataatgatactttaatgaaggggggatc t" /listShort="yrdQ, S999" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2542215..2542234 /Source="Nicolas_upshift_promotors" /id="U2050" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.601398601398601" /psig="0.905094905094905" /xcortree=1788 /SigmaFactorBS="aaattacaatgagaaTTATaaaaagaagtaagcATCAAGTAA AATGAACAAAAgtgatgaaaaacatcattgataatgatactttaatgaaggggggatc t" /listShort="yrdQ, S999" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2542242 /Source="Nicolas_upshifts" /id="U2050" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.601398601398601" /psig="0.905094905094905" /xcortree=1788 /SigmaFactorBS="aaattacaatgagaaTTATaaaaagaagtaagcATCAAGTAA AATGAACAAAAgtgatgaaaaacatcattgataatgatactttaatgaaggggggatc t" /listShort="yrdQ, S999" /GFF_Attribute="listLong" CDS 2542285..2543151 /gene="czcR" /locus_tag="BSU_26630" /old_locus_tag="BSU26630" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 22666466, 25437189; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family)" /protein_id="NP_390540.1" /db_xref="EnsemblGenomes-Gn:BSU26630" /db_xref="EnsemblGenomes-Tr:CAB14604" /db_xref="GOA:P71025" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12288" /db_xref="UniProtKB/Swiss-Prot:P71025" /translation="MELRDLQIFKCVAHHKSITGAAKELNYVQSNVTARIKQLENELK TPLFNRHKKGVSLSPEGRKMIEYVNKILKDVEELEQVFLDTEIPSGILKIGTVETVRI LPTIIASYYKKYPNVDLSLQAGLTEELIKKVMNHELDGAFISGPLKHSILEQYDVYTE KLTLVTSNKTFNIEDFSTTPILVFNQGCGYRSRLEQWLKDEGVLPNRMMEFNILETIL NSVALGLGITVVPESAVMHLAVQGKVYCHPLPEKDSCISTIFIRHKDAYLTNSMRSLL KTIVEHKNMSMA*" gene 2542285..2543151 /gene="czcR" /locus_tag="BSU_26630" /old_locus_tag="BSU26630" S_feature 2543152..2543252 /Source="Nicolas_S_feature" /locus_tag="new_2722645_2722745" /HighExp="HiTm, dia15, LBGstat, LPhT, T0.30H, Diami, Paraq, dia5, H2O2, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.905" /TUlongSig="NA" /TUlongPSig="NA" /label="S999" downshifts 2543210 /Source="Nicolas_upshifts" /id="D1364" /incds=0 /nref=6 /ntot=135 /MaxReadThrough="2.57006" /MaxDrop="3.43983" /score="-6.36950065" /energy="-7" /TU="NA" /idTUdmin="U2050" /TUdmin=0 /isTUend="TRUE" CDS complement(2543274..2544311) /gene="yrdP" /locus_tag="BSU_26640" /old_locus_tag="BSU26640" /EC_number="1.14.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9099864, 12100555, 12527699; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_390541.1" /db_xref="EnsemblGenomes-Gn:BSU26640" /db_xref="EnsemblGenomes-Tr:CAB14605" /db_xref="GOA:O07085" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR000960" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11980" /db_xref="UniProtKB/Swiss-Prot:O07085" /translation="MYDTIVIGAGQAGISIGYYLKQSDQKFIILDKSHEVGESWKDRY DSLVLFTSRMYSSLPGMHLEGEKHGFPSKNEIVAYLKKYVKKFEIPIQLRTEVISVLK IKNYFLIKTNREEYQTKNLVIATGPFHTPNIPSISKDLSDNINQLHSSQYKNSKQLAY GNVLVVGGGNSGAQIAVELSKERVTYLACSNKLVYFPLMIGKRSIFWWFDKLGVLHAS HTSIVGKFIQKKGDPVFGHELKHAIKQKEIILKKRVIAAKQNEIIFKDSSTLEVNNII WATGFRNPLCWINIKGVLDQEGRIIHHRGVSPVEGLYFIGLPWQHKRGSALLQGVGND AEYIVKQMNGE*" gene complement(2543274..2544311) /gene="yrdP" /locus_tag="BSU_26640" /old_locus_tag="BSU26640" downshifts complement(2543286) /Source="Nicolas_upshifts" /id="D1365" /incds=0 /nref=30 /ntot=134 /MaxReadThrough="2.50972" /MaxDrop="5.83595" /score="2.19797168" /energy="-12.5" /TU="NA" /idTUdmin="U2051" /TUdmin=0 /isTUend="TRUE" S_feature complement(2544312..2544398) /Source="Nicolas_S_feature" /locus_tag="new_2723805_2723891_c" /HighExp="LBGtran, dia5, Gly, Diami, LBGstat, M0t45, LBGexp, Lbtran, dia0, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.907, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1000" CDS complement(2544399..2545334) /gene="czcD" /locus_tag="BSU_26650" /old_locus_tag="BSU26650" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10735849, 12100555, 15849754, 15948947, 16850406, 22447126, 26787764, 27210016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735849, 12100555, 15849754, 15948947, 16850406, 22447126, 26787764, 27210016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium/proton-divalent cation antiporter" /protein_id="NP_390542.1" /db_xref="EnsemblGenomes-Gn:BSU26650" /db_xref="EnsemblGenomes-Tr:CAB14606" /db_xref="GOA:O07084" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG11931" /db_xref="UniProtKB/Swiss-Prot:O07084" /translation="MGHNHNEGANKKVLLISFIMITGYMIIEAIGGFLTNSLALLSDA GHMLSDSISLMVALIAFTLAEKKANHNKTFGYKRFEILAAVINGAALILISLYIIYEA IERFSNPPKVATTGMLTISIIGLVVNLLVAWIMMSGGDTKNNLNIRGAYLHVISDMLG SVGAILAAILIIFFGWGWADPLASIIVAILVLRSGYNVTKDSIHILMEGTPENIDVSD IIRTIEGTEGIQNIHDLHIWSITSGLNALSCHAVVDDQLTISESENILRKIEHELEHK GITHVTIQMETEAHNHDNAILCQPKMEKQRDHHHH*" gene complement(2544399..2545334) /gene="czcD" /locus_tag="BSU_26650" /old_locus_tag="BSU26650" promotor_-10 complement(2545369..2545388) /Source="Nicolas_upshift_promotors" /id="U2051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig="0.907092907092907" /xcortree=1543 /SigmaFactorBS="ctcatatataaatattatttgtatcaTGTTAGAAtgcttcat aacagaTTTGAAATAATAAATACATAtgtattaaaaactttaggtaaggaggagtttt t" /listShort="czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2545376) /Source="Nicolas_upshifts" /id="U2051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig="0.907092907092907" /xcortree=1543 /SigmaFactorBS="ctcatatataaatattatttgtatcaTGTTAGAAtgcttcat aacagaTTTGAAATAATAAATACATAtgtattaaaaactttaggtaaggaggagtttt t" /listShort="czcD, S1000, yrdP" /GFF_Attribute="listLong" S_feature complement(2545378..2545461) /Source="Nicolas_S_feature" /locus_tag="new_2724871_2724954_c" /HighExp="dia5, Gly, LBGtran, Diami, LBGstat, LBGexp, LoTm, dia0, Lbexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1001" promotor_-35 complement(2545403..2545410) /Source="Nicolas_upshift_promotors" /id="U2051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig="0.907092907092907" /xcortree=1543 /SigmaFactorBS="ctcatatataaatattatttgtatcaTGTTAGAAtgcttcat aacagaTTTGAAATAATAAATACATAtgtattaaaaactttaggtaaggaggagtttt t" /listShort="czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2545442..2545461) /Source="Nicolas_upshift_promotors" /id="U2052" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.546453546453546" /psig=1 /xcortree=1541 /SigmaFactorBS="gaataattaaggaggtattgtggatttctataaaaatatTTT GACATttcagtaaagagcAGATATATTTATATATGAACacatgctcatatataaatat t" /listShort="S1001, czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2545461) /Source="Nicolas_upshifts" /id="U2052" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.546453546453546" /psig=1 /xcortree=1541 /SigmaFactorBS="gaataattaaggaggtattgtggatttctataaaaatatTTT GACATttcagtaaagagcAGATATATTTATATATGAACacatgctcatatataaatat t" /listShort="S1001, czcD, S1000, yrdP" /GFF_Attribute="listLong" promotor_-35 complement(2545475..2545482) /Source="Nicolas_upshift_promotors" /id="U2052" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.546453546453546" /psig=1 /xcortree=1541 /SigmaFactorBS="gaataattaaggaggtattgtggatttctataaaaatatTTT GACATttcagtaaagagcAGATATATTTATATATGAACacatgctcatatataaatat t" /listShort="S1001, czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2545596) /Source="Nicolas_upshifts" /id="D1366" /incds=0 /nref=1 /ntot=41 /MaxReadThrough="3.75163" /MaxDrop="3.57795" /score="38.5313506" /energy="-18.1" /TU="NA" /idTUdmin="U2051" /TUdmin="-2310" /isTUend="FALSE" CDS complement(2545621..2546010) /gene="yrdN" /locus_tag="BSU_26660" /old_locus_tag="BSU26660" /EC_number="5.3.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tautomerase" /protein_id="NP_390543.1" /db_xref="EnsemblGenomes-Gn:BSU26660" /db_xref="EnsemblGenomes-Tr:CAB14607" /db_xref="GOA:P94502" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG12287" /db_xref="UniProtKB/Swiss-Prot:P94502" /translation="MPLLRFDLIEGRDQSSLKKLLDVAHNVVVEAFDVPQQDRYQIVH EHPENHMIIEDTGLGFNRTKNLVVLSVTSKSRPEEKKQKFYRLLAERLESECGIASTD LIVSIVENDNADWSFGLGEAQFLTGKL*" gene complement(2545621..2546010) /gene="yrdN" /locus_tag="BSU_26660" /old_locus_tag="BSU26660" promotor_-35 2546258..2546265 /Source="Nicolas_upshift_promotors" /id="U2053" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2368 /SigmaFactorBS="ttagaaatcatttattcttctaagctttAGTTTACAtgaagc tctgctatcATATATAATTCAAAATTAAGatggaagacatctcaaaatcagatatcaa c" /listShort="gltR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2546281..2546300 /Source="Nicolas_upshift_promotors" /id="U2053" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2368 /SigmaFactorBS="ttagaaatcatttattcttctaagctttAGTTTACAtgaagc tctgctatcATATATAATTCAAAATTAAGatggaagacatctcaaaatcagatatcaa c" /listShort="gltR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2546290 /Source="Nicolas_upshifts" /id="U2053" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2368 /SigmaFactorBS="ttagaaatcatttattcttctaagctttAGTTTACAtgaagc tctgctatcATATATAATTCAAAATTAAGatggaagacatctcaaaatcagatatcaa c" /listShort="gltR" /GFF_Attribute="listLong" CDS 2546344..2547234 /gene="gltR" /locus_tag="BSU_26670" /old_locus_tag="BSU26670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9023181, 28294562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023181, 28294562; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family)" /protein_id="NP_390544.2" /db_xref="EnsemblGenomes-Gn:BSU26670" /db_xref="EnsemblGenomes-Tr:CAB14608" /db_xref="GOA:P94501" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11942" /db_xref="UniProtKB/Swiss-Prot:P94501" /translation="MNIQLLQVFLTTAREGSISKAALTLNYAQSNVTNKIQQLENDLQ TKLFYRHSRGITLTPPGQILVSYSEKILHTIEEARAAMGESSAPSGPLRIGSMETTAA VWLPQLLAHYNNLYPNVDLNLVTGPTEQQIQAVLHYELNGAFISGPIEHPDLVQEKVL DEEMVLVTSASHPVISSIQDVQTQTMLVFRKGCSYRAKLNHILQEEGLLPIKLMEFGI LEAIIGCVSAGLGISLLPRSIIASHEKEGRIRSHTISDKYSFVSTMFIRRKDTLITPA LSAFLTHMRDHFQIKRPDQS*" gene 2546344..2547234 /gene="gltR" /locus_tag="BSU_26670" /old_locus_tag="BSU26670" promotor_-35 2546922..2546927 /Source="Nicolas_upshift_promotors" /id="U2054" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1013 /SigmaFactorBS="acacaaacaatgcttgtattccgtaaaggatgCTCATAcaga gcaaagctcaaTCATATCCTGCAAGAAGAAggtttattacctataaaattaatggaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2546943..2546961 /Source="Nicolas_upshift_promotors" /id="U2054" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1013 /SigmaFactorBS="acacaaacaatgcttgtattccgtaaaggatgCTCATAcaga gcaaagctcaaTCATATCCTGCAAGAAGAAggtttattacctataaaattaatggaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2546950 /Source="Nicolas_upshifts" /id="U2054" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1013 /SigmaFactorBS="acacaaacaatgcttgtattccgtaaaggatgCTCATAcaga gcaaagctcaaTCATATCCTGCAAGAAGAAggtttattacctataaaattaatggaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2547392..2547709) /gene="yrdK" /locus_tag="BSU_26680" /old_locus_tag="BSU26680" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390545.3" /db_xref="EnsemblGenomes-Gn:BSU26680" /db_xref="EnsemblGenomes-Tr:CAB14609" /db_xref="SubtiList:BG12286" /db_xref="UniProtKB/Swiss-Prot:P94500" /translation="MRLYTEYIPNKNKLINQQQYHSDLQDLLHQWILQLLQLDVLPLS NRKYQSSRCHPKSVGEYLIVVRAIDALGNSQPLTSRRNQVSRAMTFVQNSLNEENLHP NID*" gene complement(2547392..2547709) /gene="yrdK" /locus_tag="BSU_26680" /old_locus_tag="BSU26680" CDS complement(2547667..2548989) /gene="brnQ" /locus_tag="BSU_26690" /old_locus_tag="BSU26690" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8544834, 9287000, 9531631, 15849754, 16850406, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8544834, 9287000, 9531631, 15849754, 16850406, 25645558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="low-affinity branched-chain amino acid transporter" /protein_id="NP_390546.1" /db_xref="EnsemblGenomes-Gn:BSU26690" /db_xref="EnsemblGenomes-Tr:CAB14610" /db_xref="GOA:P94499" /db_xref="InterPro:IPR004685" /db_xref="SubtiList:BG11918" /db_xref="UniProtKB/Swiss-Prot:P94499" /translation="MSKKVSASYIIIIGLMLFALFFGAGNLIFPPMLGQLAGKNVWVA NAGFLVTGVGLPLLAITAFVFSGKQNLQSLASRVHPVFGIVFTTILYLAIGPFFAIPR SGNVSFEIGVKPFLSNDASPVSLIIFTILFFALACLLSLNPSKIIDIVGKFLTPIKLT FIGLLVAVALIRPIGTIQAPSKGYTSQAFFKGFQEGYLTLDALVAFVFGIIIVNALKE QGASTKKQLIVVCAKAAAIAAVLLAVMYTALSYMGASSVEELGILENGAEVLAKVSSY YFGSYGSILLGLMITVACLTTSVGLITACSSFFHELFPNISYKKIAVVLSVFSTLVAN IGLTQLIKVSMPVLLTMYPIAISLIFLTFLHSVFKGKTEVYQGSLLFAFIISLFDGLK AAGIKIEVVNRIFTQILPMYNIGLGWLIPAIAGGICGYILSIFRTKTS*" gene complement(2547667..2548989) /gene="brnQ" /locus_tag="BSU_26690" /old_locus_tag="BSU26690" CDS complement(2549154..2549486) /gene="azlD" /locus_tag="BSU_26700" /old_locus_tag="BSU26700" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9287000, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287000, 25645558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid / methionine exporter" /protein_id="NP_390547.1" /db_xref="EnsemblGenomes-Gn:BSU26700" /db_xref="EnsemblGenomes-Tr:CAB14611" /db_xref="GOA:O07923" /db_xref="InterPro:IPR008407" /db_xref="SubtiList:BG11916" /db_xref="UniProtKB/Swiss-Prot:O07923" /translation="MTMTMTQQMITIAMVVLGTMLTRFLPFMIFPSGKPTPKYVQYLG KVLPSAVIGLLVIYCLKDVSLLSGSHGIPELVGAAAVVLLHLWKKNMLLSIAGGTVVY MVLVQLVF*" gene complement(2549154..2549486) /gene="azlD" /locus_tag="BSU_26700" /old_locus_tag="BSU26700" CDS complement(2549483..2550247) /gene="azlC" /locus_tag="BSU_26710" /old_locus_tag="BSU26710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9287000, 15849754, 16850406, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287000, 15849754, 16850406, 25645558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid / methionine exporter" /protein_id="NP_390548.1" /db_xref="EnsemblGenomes-Gn:BSU26710" /db_xref="EnsemblGenomes-Tr:CAB14612" /db_xref="GOA:O07942" /db_xref="InterPro:IPR004471" /db_xref="InterPro:IPR011606" /db_xref="SubtiList:BG11915" /db_xref="UniProtKB/Swiss-Prot:O07942" /translation="MNKNKESLHLSSPAINTHMNKRSQIWAAFRSAFPYTIPIFAGFL FLGIAYGIFMHSLGFSAIYPIIMSFMIFAGSMEFVAANFLLGAFNPMNALFLTLMVNA RHLFYGISMLDKYRGTGKKKLYLIFGMCDESFSINYTANVPANVDKGWFMFFVTLLNH LYWVAGAAIGGIFGSYVKFNTEGLDFVMTALFIVIFIEQWMKEKKHYSALTGLGLSVA SLILFGGNQFIIPAMLAILGVLTVLRKPLEKAEVSV*" gene complement(2549483..2550247) /gene="azlC" /locus_tag="BSU_26710" /old_locus_tag="BSU26710" CDS complement(2550260..2550733) /gene="azlB" /locus_tag="BSU_26720" /old_locus_tag="BSU26720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9023181, 9287000, 26473603" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023181, 9287000, 26473603; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the azlBCD operon" /protein_id="NP_390549.1" /db_xref="EnsemblGenomes-Gn:BSU26720" /db_xref="EnsemblGenomes-Tr:CAB14613" /db_xref="GOA:O07920" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019885" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11914" /db_xref="UniProtKB/Swiss-Prot:O07920" /translation="MGIMLDETDKAILRDLQEDASISNLNLSKKIGLSPSACLARTKN LVEAGIIKKFTTIVDEKKLGIEVTALALINLSPLNRETIHSFLEDINKFPQVQECYTL TGSHDYMLKIVAKDMESYRNFIIDSLMQNPAISGVDTSIVMSTEKRTVSVPIDEM*" gene complement(2550260..2550733) /gene="azlB" /locus_tag="BSU_26720" /old_locus_tag="BSU26720" CDS complement(2551067..2551342) /gene="yrdF" /locus_tag="BSU_26730" /old_locus_tag="BSU26730" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative ribonuclease inhibitor" /protein_id="NP_390550.1" /db_xref="EnsemblGenomes-Gn:BSU26730" /db_xref="EnsemblGenomes-Tr:CAB14614" /db_xref="GOA:O07938" /db_xref="InterPro:IPR000468" /db_xref="InterPro:IPR035905" /db_xref="SubtiList:BG12285" /db_xref="UniProtKB/Swiss-Prot:O07938" /translation="MRKIIIDGRDFENIEVLHDDLKDKLDFPDYYGRNLDALWDCLTG WVDLPLTLVLKNFEFSNTFLGSYADDVLEVIQEAQEELKDEFKIIIE*" gene complement(2551067..2551342) /gene="yrdF" /locus_tag="BSU_26730" /old_locus_tag="BSU26730" misc_feature complement(2551354..2551373) /Source="Nicolas_upshift_promotors" /id="U2055" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.972027972027972" /xcortree=3056 /SigmaFactorBS="ttttcagcctcatttggacaaacagctgttacatagtaaacg tttgtTAAGATAAAATAATGGAGGGcatagtttctaatgagaaaaataataatagatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2551360) /Source="Nicolas_upshifts" /id="U2055" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.972027972027972" /xcortree=3056 /SigmaFactorBS="ttttcagcctcatttggacaaacagctgttacatagtaaacg tttgtTAAGATAAAATAATGGAGGGcatagtttctaatgagaaaaataataatagatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2551428..2551613) /Source="Nicolas_S_feature" /locus_tag="new_2730921_2731106_c" /HighExp="BT, S4, S8, S3, S5, S7, S6, LoTm, B36, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.977" /TUlongSig="NA" /TUlongPSig="NA" /label="S1002" CDS complement(2551614..2552846) /gene="cypA" /locus_tag="BSU_26740" /old_locus_tag="BSU26740" /EC_number="1.14.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9778370, 12354229, 28898812" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9778370, 12354229, 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450" /protein_id="NP_390551.1" /db_xref="EnsemblGenomes-Gn:BSU26740" /db_xref="EnsemblGenomes-Tr:CAB14615" /db_xref="GOA:O08469" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG11929" /db_xref="UniProtKB/Swiss-Prot:O08469" /translation="MSSKEKKSVTILTESQLSSRAFKDEAYEFYKELRKSQALYPLSL GALGKGWLISRYDDAIHLLKNEKLKKNYENVFTAKEKRPALLKNEETLTKHMLNSDPP DHNRLRTLVQKAFTHRMILQLEDKIQHIADSLLDKVQPNKFMNLVDDYAFPLPIIVIS EMLGIPLEDRQKFRVWSQAIIDFSDAPERLQENDHLLGEFVEYLESLVRKKRREPAGD LISALIQAESEGTQLSTEELYSMIMLLIVAGHETTVNLITNMTYALMCHHDQLEKLRQ QPDLMNSAIEEALRFHSPVELTTIRWTAEPFILHGQEIKRKDVIIISLASANRDEKIF PNADIFDIERKNNRHIAFGHGNHFCLGAQLARLEAKIAISTLLRRCPNIQLKGEKKQM KWKGNFLMRALEELPISF*" gene complement(2551614..2552846) /gene="cypA" /locus_tag="BSU_26740" /old_locus_tag="BSU26740" CDS complement(2552896..2553054) /gene="yrdDc" /locus_tag="BSU_26748" /old_locus_tag="BSU26748" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; C-terminal part of YrdD" /db_xref="PSEUDO:CAX52669.1" /translation="MEVLGVSPFYQGKSLGSKMINDCLISFISKCGDGILALIMNTDL NGSFYKSS*" gene complement(2552896..2553054) /gene="yrdDc" /locus_tag="BSU_26748" /old_locus_tag="BSU26748" /pseudo CDS complement(2553051..2553254) /gene="yrdDm" /locus_tag="BSU_26749" /old_locus_tag="BSU26749" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; internal part of YrdD" /db_xref="SubtiList:BG12284" /translation="MHKVLTRAYFKKHFFFVGIQNGEMVVAALLKHRDKPDIKLDRLY SSRGDNINQNGAKKFSKSLKEPA*" gene complement(2553051..2553254) /gene="yrdDm" /locus_tag="BSU_26749" /old_locus_tag="BSU26749" /pseudo promotor_-10 complement(2553215..2553233) /Source="Nicolas_upshift_promotors" /id="U2056" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1116 /SigmaFactorBS="gtaaaacgcgaaaaaaagatcattcatttatttttgaaaTGC ATAaagtactgacaagaGCATATTTTAAAAAGCATTtcttttttgttggcattcagaa t" /listShort="yrdD, yrdD, cypA, S1002" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2553232) /Source="Nicolas_upshifts" /id="U2056" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1116 /SigmaFactorBS="gtaaaacgcgaaaaaaagatcattcatttatttttgaaaTGC ATAaagtactgacaagaGCATATTTTAAAAAGCATTtcttttttgttggcattcagaa t" /listShort="yrdD, yrdD, cypA, S1002" /GFF_Attribute="listLong" CDS complement(2553239..2553388) /gene="yrdDn" /locus_tag="BSU_26750" /old_locus_tag="BSU26750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; N-terminal part of YrdD" /db_xref="SubtiList:BG14036" /translation="MFLYRQARADEVSKVAKLFHQSFNQYPFMDLLVKREKKIIHLFL KCIKY*" gene complement(2553239..2553388) /gene="yrdDn" /locus_tag="BSU_26750" /old_locus_tag="BSU26750" /pseudo promotor_-35 complement(2553248..2553253) /Source="Nicolas_upshift_promotors" /id="U2056" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1116 /SigmaFactorBS="gtaaaacgcgaaaaaaagatcattcatttatttttgaaaTGC ATAaagtactgacaagaGCATATTTTAAAAAGCATTtcttttttgttggcattcagaa t" /listShort="yrdD, yrdD, cypA, S1002" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2553472) /Source="Nicolas_upshifts" /id="D1367" /incds=0 /nref=140 /ntot=216 /MaxReadThrough="2.2276" /MaxDrop="4.5127" /score="5.01317133" /energy="-16.7" /TU="NA" /idTUdmin="U2057" /TUdmin=0 /isTUend="TRUE" CDS complement(2553487..2554050) /gene="yrdC" /locus_tag="BSU_26760" /old_locus_tag="BSU26760" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390553.1" /db_xref="EnsemblGenomes-Gn:BSU26760" /db_xref="EnsemblGenomes-Tr:CAB14617" /db_xref="GOA:O07081" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12283" /db_xref="UniProtKB/Swiss-Prot:O07081" /translation="MEEKKALIIVDVQKAFDDKKWGERNNVKAEENISKILELWREKG WTVIYIQHTSDKPHSLFHPKNEGFAIKEIVKPMDEEVIITKTVNSSFIGTNLEEFLKL NEITTVVITGLTTPHCVSTTTRMSGNLGFDTYLISDATAAFGMRDQNDTYYDAATIHN ISLATLHDEFATILTTDQLINDFIKTH*" gene complement(2553487..2554050) /gene="yrdC" /locus_tag="BSU_26760" /old_locus_tag="BSU26760" downshifts 2553968 /Source="Nicolas_upshifts" /id="D1368" /incds=1 /nref=44 /ntot=194 /MaxReadThrough="1.72227" /MaxDrop="3.37915" /score="14.6499034" /energy="-6.6" /TU="NA" /idTUdmin="U2060" /TUdmin="-4488" /isTUend="FALSE" promotor_-10 complement(2554080..2554099) /Source="Nicolas_upshift_promotors" /id="U2057" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.856143856143856" /psig="0.997002997002997" /xcortree=2342 /SigmaFactorBS="ggcgctcatttgaaattcatcattaaaCAATTGTAcaaaagt aaaatttGTATTTAGAATGTAGTAATAaatagaaattctacgtaggagggtatcttgt g" /listShort="yrdC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2554088) /Source="Nicolas_upshifts" /id="U2057" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.856143856143856" /psig="0.997002997002997" /xcortree=2342 /SigmaFactorBS="ggcgctcatttgaaattcatcattaaaCAATTGTAcaaaagt aaaatttGTATTTAGAATGTAGTAATAaatagaaattctacgtaggagggtatcttgt g" /listShort="yrdC" /GFF_Attribute="listLong" promotor_-35 complement(2554114..2554121) /Source="Nicolas_upshift_promotors" /id="U2057" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.856143856143856" /psig="0.997002997002997" /xcortree=2342 /SigmaFactorBS="ggcgctcatttgaaattcatcattaaaCAATTGTAcaaaagt aaaatttGTATTTAGAATGTAGTAATAaatagaaattctacgtaggagggtatcttgt g" /listShort="yrdC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2554279..2554650) /gene="yrdB" /locus_tag="BSU_26770" /old_locus_tag="BSU26770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390554.1" /db_xref="EnsemblGenomes-Gn:BSU26770" /db_xref="EnsemblGenomes-Tr:CAB14618" /db_xref="GOA:O07080" /db_xref="InterPro:IPR021214" /db_xref="SubtiList:BG12282" /db_xref="UniProtKB/Swiss-Prot:O07080" /translation="MEKLNQTNLLLRFTLEIAALISLGVYAWISFNGYFKYVLTLVLP IAVMIVWSVFAVPHDPSRSGQTVIAVNGVTRLVIELLIFAMAVAALYFSYLKPVSIVF LCLIILHYIISAERIKWLLNQ*" gene complement(2554279..2554650) /gene="yrdB" /locus_tag="BSU_26770" /old_locus_tag="BSU26770" S_feature complement(2554651..2554880) /Source="Nicolas_S_feature" /locus_tag="new_2734144_2734373_c" /HighExp="BMM, GM 120, GM 90, SMM, MG 150, GM 60, MG 120, M9-tran, Glu, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.48162700000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1003" promotor_-10 complement(2554862..2554881) /Source="Nicolas_upshift_promotors" /id="U2058" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=3041 /SigmaFactorBS="gtataatctttacttcgttcgacaaattctgcaaatTGTAGA CAacttcctgattatTTGGATAATTAACTGAATAGgaggggaaaagttgtcatatttc a" /listShort="S1003, yrdB" /listLong="yrdC" /label="promotor_-10" upshifts complement(2554878) /Source="Nicolas_upshifts" /id="U2058" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=3041 /SigmaFactorBS="gtataatctttacttcgttcgacaaattctgcaaatTGTAGA CAacttcctgattatTTGGATAATTAACTGAATAGgaggggaaaagttgtcatatttc a" /listShort="S1003, yrdB" /listLong="yrdC" promotor_-35 complement(2554895..2554902) /Source="Nicolas_upshift_promotors" /id="U2058" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=3041 /SigmaFactorBS="gtataatctttacttcgttcgacaaattctgcaaatTGTAGA CAacttcctgattatTTGGATAATTAACTGAATAGgaggggaaaagttgtcatatttc a" /listShort="S1003, yrdB" /listLong="yrdC" /label="promotor_-35" downshifts complement(2555446) /Source="Nicolas_upshifts" /id="D1369" /incds=0 /nref=174 /ntot=248 /MaxReadThrough="2.42722" /MaxDrop="5.81863" /score="7.90390368" /energy="-10.3" /TU="NA" /idTUdmin="U2059" /TUdmin=6 /isTUend="TRUE" CDS complement(2555460..2555963) /gene="yrdA" /locus_tag="BSU_26780" /old_locus_tag="BSU26780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390555.1" /db_xref="EnsemblGenomes-Gn:BSU26780" /db_xref="EnsemblGenomes-Tr:CAB14619" /db_xref="GOA:O07079" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG12281" /db_xref="UniProtKB/Swiss-Prot:O07079" /translation="MFQTLDHFLKSWEFEADATQKLLNSLTDESLKQEITSQNWTLGR IAWHTVAAIGIITSNTDLTFQAPAEDYPVPTSAQFIADSYHQASNAFVQALKTQWTDH TLQERINFIGQQMPNGSLLMFLIQHQNHHRGQMTVLMRQAGLTVPGIYGPAKEEWAKF GLEAPKM*" gene complement(2555460..2555963) /gene="yrdA" /locus_tag="BSU_26780" /old_locus_tag="BSU26780" S_feature complement(2555964..2556188) /Source="Nicolas_S_feature" /locus_tag="new_2735457_2735681_c" /HighExp="Etha, Lbstat, M0t90, M40t90, LoTm, M9-stat, Gly, S2, T0.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1004" CDS complement(2556189..2557043) /gene="aadK" /locus_tag="BSU_26790" /old_locus_tag="BSU26790" /EC_number="2.7.7.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8293959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8293959; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aminoglycoside 6-adenylyltransferase" /protein_id="NP_390556.1" /db_xref="EnsemblGenomes-Gn:BSU26790" /db_xref="EnsemblGenomes-Tr:CAB14620" /db_xref="GOA:P17585" /db_xref="InterPro:IPR007530" /db_xref="PDB:2PBE" /db_xref="SubtiList:BG11037" /db_xref="UniProtKB/Swiss-Prot:P17585" /translation="MRSEQEMMDIFLDFALNDERIRLVTLEGSRTNRNIPPDNFQDYD ISYFVTDVESFKENDQWLEIFGKRIMMQKPEDMELFPPELGNWFSYIILFEDGNKLDL TLIPIREAEDYFANNDGLVKVLLDKDSFINYKVTPNDRQYWIKRPTAREFDDCCNEFW MVSTYVVKGLARNEILFAIDHLNEIVRPNLLRMMAWHIASQKGYSFSMGKNYKFMKRY LSNKEWEELMSTYSVNGYQEMWKSLFTCYALFRKYSKAVSEGLAYKYPDYDEGITKYT EGIYCSVK*" gene complement(2556189..2557043) /gene="aadK" /locus_tag="BSU_26790" /old_locus_tag="BSU26790" S_feature complement(2557044..2557146) /Source="Nicolas_S_feature" /locus_tag="new_2736537_2736639_c" /HighExp="M9-stat, T3.0H, T0.30H, T1.30H, T2.30H, Lbtran, T3.30H, T1.0H, M0t90, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1005" promotor_-10 complement(2557127..2557146) /Source="Nicolas_upshift_promotors" /id="U2059" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=3219 /SigmaFactorBS="gttgatatctgattttgagatgtcttgcatcttaatattgAA TGatatataggagaacATCATGTAAAATAAAGCTTAgaagaatacatcacattcaaga g" /listShort="S1005, aadK, S1004, yrdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2557144) /Source="Nicolas_upshifts" /id="U2059" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=3219 /SigmaFactorBS="gttgatatctgattttgagatgtcttgcatcttaatattgAA TGatatataggagaacATCATGTAAAATAAAGCTTAgaagaatacatcacattcaaga g" /listShort="S1005, aadK, S1004, yrdA" /GFF_Attribute="listLong" promotor_-35 complement(2557161..2557164) /Source="Nicolas_upshift_promotors" /id="U2059" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=3219 /SigmaFactorBS="gttgatatctgattttgagatgtcttgcatcttaatattgAA TGatatataggagaacATCATGTAAAATAAAGCTTAgaagaatacatcacattcaaga g" /listShort="S1005, aadK, S1004, yrdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2557315..2557322 /Source="Nicolas_upshift_promotors" /id="U2060" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.723276723276723" /psig="0.894105894105894" /xcortree=2930 /SigmaFactorBS="atcgacatgttaactggtatgagaGATTGACAaaaagaagga aaaCGATATATTTAAGCGAATACgagtttttgagtaaattttaaaatgacactttttt c" /listShort="S1006, yrpB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2557336..2557355 /Source="Nicolas_upshift_promotors" /id="U2060" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.723276723276723" /psig="0.894105894105894" /xcortree=2930 /SigmaFactorBS="atcgacatgttaactggtatgagaGATTGACAaaaagaagga aaaCGATATATTTAAGCGAATACgagtttttgagtaaattttaaaatgacactttttt c" /listShort="S1006, yrpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2557351 /Source="Nicolas_upshifts" /id="U2060" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.723276723276723" /psig="0.894105894105894" /xcortree=2930 /SigmaFactorBS="atcgacatgttaactggtatgagaGATTGACAaaaagaagga aaaCGATATATTTAAGCGAATACgagtttttgagtaaattttaaaatgacactttttt c" /listShort="S1006, yrpB" /GFF_Attribute="listLong" S_feature 2557356..2557421 /Source="Nicolas_S_feature" /locus_tag="new_2736849_2736914" /HighExp="LoTm, BC, S1, S2, C90, T4.0H, HiOs, T5.0H, T3.30H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.894" /TUlongSig="NA" /TUlongPSig="NA" /label="S1006" CDS 2557422..2558465 /gene="yrpB" /locus_tag="BSU_26800" /old_locus_tag="BSU26800" /EC_number="1.13.12.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9501443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative anionic nitroalkane monoxygenase" /protein_id="NP_390557.1" /db_xref="EnsemblGenomes-Gn:BSU26800" /db_xref="EnsemblGenomes-Tr:CAB14621" /db_xref="GOA:O05413" /db_xref="InterPro:IPR004136" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG12305" /db_xref="UniProtKB/Swiss-Prot:O05413" /translation="MNEFMKKFSLTKPIIQAPMAGGITKPRLASAVSNQGALGSLASG YLTPDLLEQQIKEIFELTDAPFQINVFVPLGLEMPPKDQIKKWKENIPLANQVNQFTS VQEEWDDFYQKIDLILKYKVKACSFTFDLPPEDAVKELKTAGCCLIGTASTVEEALLM EERGMDIVVLQGSEAGGHRGAFLPSKGESAVGLMALIPQAADALSVPVIAAGGMIDHR GVKAALTLGAQGVQIGSAFLICHESNAHPVHKQKILEANEADTKLTTLFSGKEARGIV NKWMEENEQFETQTLPYPYQNTLTKAMRQKASLQNNHDQMSLWAGQGIRSLTEEISVK QLLNQLCQEDIKI*" gene 2557422..2558465 /gene="yrpB" /locus_tag="BSU_26800" /old_locus_tag="BSU26800" downshifts 2558463 /Source="Nicolas_upshifts" /id="D1370" /incds=0 /nref=22 /ntot=198 /MaxReadThrough="1.3622" /MaxDrop="5.04821" /score="14.6499034" /energy="-6.6" /TU="NA" /idTUdmin="U2060" /TUdmin=7 /isTUend="TRUE" promotor_-35 2558750..2558757 /Source="Nicolas_upshift_promotors" /id="U2061" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95904095904096" /psig=1 /xcortree=2015 /SigmaFactorBS="atcgatagctcccatattaaatttgaatagtaaaatggttct ttttCGTTTGATtcagatgatataaAGTCATATGATAAAAAAAGAatgagacagaaag c" /listShort="yrpC" /listLong="yrpD, S1007" /label="promotor_-35" upshifts 2558764 /Source="Nicolas_upshifts" /id="U2061" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95904095904096" /psig=1 /xcortree=2015 /SigmaFactorBS="atcgatagctcccatattaaatttgaatagtaaaatggttct ttttCGTTTGATtcagatgatataaAGTCATATGATAAAAAAAGAatgagacagaaag c" /listShort="yrpC" /listLong="yrpD, S1007" promotor_-10 2558771..2558790 /Source="Nicolas_upshift_promotors" /id="U2061" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95904095904096" /psig=1 /xcortree=2015 /SigmaFactorBS="atcgatagctcccatattaaatttgaatagtaaaatggttct ttttCGTTTGATtcagatgatataaAGTCATATGATAAAAAAAGAatgagacagaaag c" /listShort="yrpC" /listLong="yrpD, S1007" /label="promotor_-10" CDS 2558815..2559612 /gene="murI" /locus_tag="BSU_26810" /old_locus_tag="BSU26810" /EC_number="5.1.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12829290, 15212785, 15347750, 17720142, 25777674" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12829290, 15212785, 15347750, 17720142, 25777674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate racemase" /protein_id="NP_390558.1" /db_xref="EnsemblGenomes-Gn:BSU26810" /db_xref="EnsemblGenomes-Tr:CAB14622" /db_xref="GOA:O05412" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004391" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="SubtiList:BG12306" /db_xref="UniProtKB/Swiss-Prot:O05412" /translation="MKIGFFDSGIGGMTVLYEAIKVLPYEDYIFYADTLNVPYGEKSK GKVKEYIFNAAEFLASQNIKALVIACNTATSIAIEDLRRNFDFPIIGIEPAVKPAINK CTEERKRVLVVATNLTLKEEKFHNLVKEIDHHDLVDCLALPGLVEFAENFDFSEDKII KYLKNELSSFDLKQYGTIVLGCTHFPFFKNSFEKLFGIKVDMISGSVGTAKQLKKVLA DRNQLGKGSGSITFFNSGHKIVDQEVISKYKRLFEILDETQRSHVGH*" gene 2558815..2559612 /gene="murI" /locus_tag="BSU_26810" /old_locus_tag="BSU26810" promotor_-35 2559918..2559922 /Source="Nicolas_upshift_promotors" /id="U2062" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.304695304695305" /psig="0.997002997002997" /xcortree=3238 /SigmaFactorBS="gtgtaaattctgtatctatgtgcatgtttattATGGAattat tttcataaTGTTTTATAATACAAGATGAtagcgttttctaattataatgataggggga a" /listShort="yrpD, S1007, S1008, S1009, S1010" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2559936..2559955 /Source="Nicolas_upshift_promotors" /id="U2062" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.304695304695305" /psig="0.997002997002997" /xcortree=3238 /SigmaFactorBS="gtgtaaattctgtatctatgtgcatgtttattATGGAattat tttcataaTGTTTTATAATACAAGATGAtagcgttttctaattataatgataggggga a" /listShort="yrpD, S1007, S1008, S1009, S1010" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2559946 /Source="Nicolas_upshifts" /id="U2062" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.304695304695305" /psig="0.997002997002997" /xcortree=3238 /SigmaFactorBS="gtgtaaattctgtatctatgtgcatgtttattATGGAattat tttcataaTGTTTTATAATACAAGATGAtagcgttttctaattataatgataggggga a" /listShort="yrpD, S1007, S1008, S1009, S1010" /GFF_Attribute="listLong" promotor_-10 complement(2559970..2559984) /Source="Nicolas_upshift_promotors" /id="U2063" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.921078921078921" /psig="0.070929070929071" /xcortree=302 /SigmaFactorBS="caaaaagcacggttgccgtaagcgcacccgcaagcagacctt ttttcATCATcattatttCCCCCTATCATTATAattagaaaacgctatcatcttgtat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2559984) /Source="Nicolas_upshifts" /id="U2063" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.921078921078921" /psig="0.070929070929071" /xcortree=302 /SigmaFactorBS="caaaaagcacggttgccgtaagcgcacccgcaagcagacctt ttttcATCATcattatttCCCCCTATCATTATAattagaaaacgctatcatcttgtat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2559993..2559997) /Source="Nicolas_upshift_promotors" /id="U2063" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.921078921078921" /psig="0.070929070929071" /xcortree=302 /SigmaFactorBS="caaaaagcacggttgccgtaagcgcacccgcaagcagacctt ttttcATCATcattatttCCCCCTATCATTATAattagaaaacgctatcatcttgtat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2559993..2560700 /gene="yrpD" /locus_tag="BSU_26820" /old_locus_tag="BSU26820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25355936; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390559.1" /db_xref="EnsemblGenomes-Gn:BSU26820" /db_xref="EnsemblGenomes-Tr:CAB14623" /db_xref="InterPro:IPR029143" /db_xref="SubtiList:BG12307" /db_xref="UniProtKB/Swiss-Prot:O05411" /translation="MMKKGLLAGALTATVLFGTCAVDVPGIISPKTAEAASQLTDGIG GRAYLNSNGAILVTKIQLPSSTQVSNGTAYIYSGFSGGTESDIGFQYSDKYNVWKPYM KVGSKGQDQVQYLEGGSQFTNTKGFRPGSTVQLTIYKNLNGNTRATYWGTNNAGYNGR LISEISKTNVGSISKWKALATVATTGSRQSIKSNFSTSFTNITIDNKAITPVIDTQDF AKVTVSGNSVSLSVVKN*" gene 2559993..2560700 /gene="yrpD" /locus_tag="BSU_26820" /old_locus_tag="BSU26820" downshifts 2560700 /Source="Nicolas_upshifts" /id="D1371" /incds=0 /nref=4 /ntot=168 /MaxReadThrough="5.98921" /MaxDrop="2.677" /score="15.7112026" /energy="-8.2" /TU="U2062" /idTUdmin="U2064" /TUdmin="-660" /isTUend="FALSE" S_feature 2560745..2560918 /Source="Nicolas_S_feature" /locus_tag="new_2740238_2740411" /HighExp="Lbstat, M0t90, M40t90, BT, S0, ferm, S2, M9-stat, Lbtran, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="SigA" /TUlongPSig=1 /label="S1007" promotor_-35 2560900..2560901 /Source="Nicolas_upshift_promotors" /id="U2064" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.591408591408591" /psig="0.861138861138861" /xcortree=1974 /SigmaFactorBS="ccccttctgaacctgttccatttgctcaacgcaaaaggtgTG catcactgtcttaaaAATGTTAAAACAAATAGCAGatggtgcactttatttttagatg a" /listShort="S1008, S1009" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2560917..2560936 /Source="Nicolas_upshift_promotors" /id="U2064" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.591408591408591" /psig="0.861138861138861" /xcortree=1974 /SigmaFactorBS="ccccttctgaacctgttccatttgctcaacgcaaaaggtgTG catcactgtcttaaaAATGTTAAAACAAATAGCAGatggtgcactttatttttagatg a" /listShort="S1008, S1009" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2560920..2561248 /Source="Nicolas_S_feature" /locus_tag="new_2740413_2740741" /HighExp="Lbstat, M0t90, BT, M40t90, S2, S0, ferm, T2.0H, M9-stat, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99711000000000005" /TUshortSig="SigA, SigA" /TUshortPSig="0.861, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1008" upshifts 2560920 /Source="Nicolas_upshifts" /id="U2064" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.591408591408591" /psig="0.861138861138861" /xcortree=1974 /SigmaFactorBS="ccccttctgaacctgttccatttgctcaacgcaaaaggtgTG catcactgtcttaaaAATGTTAAAACAAATAGCAGatggtgcactttatttttagatg a" /listShort="S1008, S1009" /GFF_Attribute="listLong" CDS 2561024..2561185 /locus_tag="BSU_26829" /old_locus_tag="BSU26829" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:SOX90581.1" /translation="MYFHKRGMASYSSIASGRLANDWPRTTHHFETDSFQNHKYDPIT NKDQLAVQP*" gene 2561024..2561185 /locus_tag="BSU_26829" /old_locus_tag="BSU26829" /pseudo promotor_-35 2561214..2561223 /Source="Nicolas_upshift_promotors" /id="U2065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1413 /SigmaFactorBS="atttttacatcaattaaactagcaTCACTATCGAataagctc gatcTGCATATCATGTACTATCCTcttttaaggaaggtgatgttatgaggtcatttcc a" /listShort="S1009, S1010" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2561236..2561255 /Source="Nicolas_upshift_promotors" /id="U2065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1413 /SigmaFactorBS="atttttacatcaattaaactagcaTCACTATCGAataagctc gatcTGCATATCATGTACTATCCTcttttaaggaaggtgatgttatgaggtcatttcc a" /listShort="S1009, S1010" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2561250..2561401 /Source="Nicolas_S_feature" /locus_tag="new_2740743_2740894" /HighExp="BT, S8, B36, S7, Lbstat, G/S, Pyr, M0t90, B60, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.94474599999999997" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.861, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1009" upshifts 2561250 /Source="Nicolas_upshifts" /id="U2065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1413 /SigmaFactorBS="atttttacatcaattaaactagcaTCACTATCGAataagctc gatcTGCATATCATGTACTATCCTcttttaaggaaggtgatgttatgaggtcatttcc a" /listShort="S1009, S1010" /GFF_Attribute="listLong" CDS 2561276..2561353 /gene="yrpDX" /locus_tag="BSU_26826" /old_locus_tag="BSU26826" /experiment="publication(s) with functional evidences, PMID:20709900" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="expressed polypeptide of unknown function" /protein_id="YP_009513985.1" /db_xref="EnsemblGenomes-Gn:BSU26826" /db_xref="EnsemblGenomes-Tr:CCQ48602" /db_xref="GOA:L8E9J8" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/TrEMBL:L8E9J8" /translation="MRSFPLIVVLFILLIIVGTSFFGGY*" gene 2561276..2561353 /gene="yrpDX" /locus_tag="BSU_26826" /old_locus_tag="BSU26826" downshifts 2561358 /Source="Nicolas_upshifts" /id="D1372" /incds=0 /nref=23 /ntot=198 /MaxReadThrough="3.86249" /MaxDrop="4.0885" /score="28.4802594" /energy="-18.1" /TU="U2062,U2065" /idTUdmin="U2064" /TUdmin="-2" /isTUend="TRUE" S_feature 2561403..2561600 /Source="Nicolas_S_feature" /locus_tag="new_2740896_2741093" /HighExp="BT, B36, S8, Lbstat, G/S, Pyr, Diami, S7, dia15, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1010" S_feature complement(2561592..2561863) /Source="Nicolas_S_feature" /locus_tag="new_2741085_2741356_c" /HighExp="Heat, BMM, Etha, S2, S3, S4, B36, S5, B60, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40965600000000002" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1011" downshifts complement(2561634) /Source="Nicolas_upshifts" /id="D1373" /incds=0 /nref=37 /ntot=78 /MaxReadThrough="2.30607" /MaxDrop="6.9537" /score="19.9821634" /energy="-15.5" /TU="NA" /idTUdmin="U2066" /TUdmin=0 /isTUend="TRUE" CDS complement(2561640..2561801) /locus_tag="BSU_26827" /old_locus_tag="BSU26827" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513986.1" /translation="MGKKLIETIQYPPYYCDVAYLESSHMKSRRNLFQNKKSLDVWQW ITLEIYWLI*" gene complement(2561640..2561801) /locus_tag="BSU_26827" /old_locus_tag="BSU26827" CDS complement(2561864..2562619) /gene="zinT" /locus_tag="BSU_26830" /old_locus_tag="BSU26830" /function="16.14: Store" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12904577, 24128931; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein buffering protein for Zn2+ transport" /protein_id="NP_390560.1" /db_xref="EnsemblGenomes-Gn:BSU26830" /db_xref="EnsemblGenomes-Tr:CAB14624" /db_xref="GOA:O05410" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR015304" /db_xref="SubtiList:BG12308" /db_xref="UniProtKB/Swiss-Prot:O05410" /translation="MNILFSKRLGILTIGSLLVLAGCQTSGSSAGESNQTTSSSAVEE DSSKTQEQTSDSHTHEHSHDHSHAHDEETEKIYEGYFKNSQVKDRLLSDWEGDWQSVY PYLQDGTLDEVFSYKSEHEGGKTAEEYKEYYKKGYQTDVDRIVIQKDTVTFFKNGKEY SGKYTYDGYEILTYDAGNRGVRYIFKLAKKAEGLPQYIQFSDHSIYPTKASHYHLYWG DDREALLDEVKNWPTYYPSKMDGHDIAHEMMAH*" gene complement(2561864..2562619) /gene="zinT" /locus_tag="BSU_26830" /old_locus_tag="BSU26830" promotor_-10 complement(2562650..2562669) /Source="Nicolas_upshift_promotors" /id="U2066" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=666 /SigmaFactorBS="tttaaaataggccatccgcatgaagagcatttttccTTTGAT gtttgcaagagatgtATGTATAATAAATCGTAATGttttcgatttaataaaaaaggag t" /listShort="yrpE, S1011" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2562666) /Source="Nicolas_upshifts" /id="U2066" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=666 /SigmaFactorBS="tttaaaataggccatccgcatgaagagcatttttccTTTGAT gtttgcaagagatgtATGTATAATAAATCGTAATGttttcgatttaataaaaaaggag t" /listShort="yrpE, S1011" /GFF_Attribute="listLong" promotor_-35 complement(2562685..2562690) /Source="Nicolas_upshift_promotors" /id="U2066" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=666 /SigmaFactorBS="tttaaaataggccatccgcatgaagagcatttttccTTTGAT gtttgcaagagatgtATGTATAATAAATCGTAATGttttcgatttaataaaaaaggag t" /listShort="yrpE, S1011" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2562751..2563281) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11700344, 15019740, 17675383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11700344, 15019740, 17675383; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma-Z)" /protein_id="NP_390561.1" /db_xref="EnsemblGenomes-Gn:BSU26840" /db_xref="EnsemblGenomes-Tr:CAB14625" /db_xref="GOA:O05409" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014304" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11976" /db_xref="UniProtKB/Swiss-Prot:O05409" /translation="MNIEDLWDQFHQPLKTYISHRVNDQSIVDDLLQIVFMKIQVHLP NLIDEQKIDSWIYRITRNTIIDFYRTKKTSEILPDVLHFNDSAEEENFTKEATVCIRS TIKRLPEKYREALELTDFQGLSQKELSEKLGISYSGAKSRVQRGRGKLKQLLEGCCHI EADRYGNIVDFRILKE*" gene complement(2562751..2563281) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" promotor_-10 complement(2563327..2563346) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2563350) /Source="Nicolas_upshifts" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2563360..2563367) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2563416..2564396 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23990306, 25326299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldo-keto reductase" /protein_id="NP_390562.2" /db_xref="EnsemblGenomes-Gn:BSU26850" /db_xref="EnsemblGenomes-Tr:CAB14626" /db_xref="GOA:O05408" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG12309" /db_xref="UniProtKB/Swiss-Prot:O05408" /translation="MEYTYLGRTGLRVSRLCLGTMNFGVDTDEKTAFRIMDEALDNGI QFFDTANIYGWGKNAGLTESIIGKWFAQGGQRREKVVLATKVYEPISDPNDGPNDMRG LSLYKIRRHLEGSLKRLQTDHIELYQMHHIDRRTPWDEIWEAFETQVRSGKVDYIGSS NFAGWHLVKAQAEAEKRRFMGLVTEQHKYSLLERTAEMEVLPAARDLGLGVVAWSPLA GGLLGGKALKSNAGTRTAKRADLIEKHRLQLEKFSDLCKELGEKEANVALAWVLANPV LTAPIIGPRTVEQLRDTIKAVEISLDKEILRMLNDIFPGPGGETPEAYAW*" gene 2563416..2564396 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" CDS complement(2564670..2565986) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053381, 11566984, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative citrate transporter" /protein_id="NP_390563.1" /db_xref="EnsemblGenomes-Gn:BSU26860" /db_xref="EnsemblGenomes-Tr:CAB14627" /db_xref="GOA:O05407" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG12279" /db_xref="UniProtKB/Swiss-Prot:O05407" /translation="MLTILGFSMVTVFTILIMTKKVSPIVALTITPIVFALIGGFGKG IGDMILEGIQTVASSAALLLFAILFFGILIDAGLFDPLIEKILSIVKGDPVKIAIGSA VLAMLIALDGDGTTTYMITVSAMLPLYKRIGMNPMVMATLAMLSLSIVSGMTPWGGPA TRAISVLGLDPSDFFVPLLPTMLGGIACVIFLAFLMGRKERNRIGIVQLEPRHITKDS SQSYMAATLESEQLKRPRLIYLNLFLVISIMVFIVLGTKHPSVLFLIGFVLALTINYP NVKMQKERIAEHSGNAITVVLLVFSAGVFAGILSGTKMVDAIAGSLISIIPSSMGGFF PVIVALTSIPFTFVLSNDAYYFGMVPIFAEAASAYGIEPVEIARASIMGQPVHLMSPL VASTVLLVSMLKMDLGSFQRFAVKWAVITSLVITLLAIITGAITIL*" gene complement(2564670..2565986) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" S_feature complement(2565987..2566100) /Source="Nicolas_S_feature" /locus_tag="new_2745480_2745593_c" /HighExp="Lbtran, M40t90, Lbstat, HiTm, Mal, Gly, M0t90, S1, T1.0H, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1012" CDS complement(2566101..2566970) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (probes citrate or citrate-related metabolite)" /protein_id="NP_390564.1" /db_xref="EnsemblGenomes-Gn:BSU26870" /db_xref="EnsemblGenomes-Tr:CAB14628" /db_xref="GOA:O07906" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12278" /db_xref="UniProtKB/Swiss-Prot:O07906" /translation="MDEKDWILLKILHEEQSVTKTAERLFTSQPSITYRLKKIEEIFG IELFTKRHKGITFTAEGEHLVAYARRMLQELQDTKDHISNLSKEVQGHLRLGVSSNFA QYKLPKLLREFSTMYPNVQYSVQTGWSTDVMKLLDAGIVQVGILRGSHRWKGVEERLT REKLHIISKKPITIEQLPFLPFIKYKTDASLKTIIEDWMHTNLKQAPIIAMEVDRQET CKEMVKHGLGYSIAPEICLQESDHLYTMELYNAKGKPLMRDTWLMYDQKSLGIKLVKA FIDFLKGEQMVTI*" gene complement(2566101..2566970) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" promotor_-10 complement(2566993..2567012) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2567010) /Source="Nicolas_upshifts" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" promotor_-35 complement(2567027..2567032) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2567077..2567078) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2567085) /Source="Nicolas_upshifts" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" promotor_-35 complement(2567115..2567116) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2567115..2568218 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" /EC_number="5.3.3.7" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11294638, 12473114, 14702315, 17567742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate isomerase" /protein_id="NP_390565.2" /db_xref="EnsemblGenomes-Gn:BSU26880" /db_xref="EnsemblGenomes-Tr:CAB14629" /db_xref="GOA:O07931" /db_xref="InterPro:IPR007400" /db_xref="SubtiList:BG12277" /db_xref="UniProtKB/Swiss-Prot:O07931" /translation="MVKTNVTIMRGGTSKGVFFHESAMPNNKNEWEPFLLDVMGSPDK RQIDGLGGGNSLTSKVAIIKKAYTSDIDVHYTFGQVSISEEKVDFKGNCGNISAAVGP FAIEEGLVKAKEPMTAVRILNTNTNKMIIAEVEVEDGQVKYDGDVTISGVPGSGSPIY LNFHDAAGSVTGHLLPTGNSSEFLDTSQGQIEVSIIDYANPLVFVEASSIGLDGTELA EEFTDLQLAQFEELRSIAAEKCGFASRFSATKLSPAVPKLAIVAKPEKYKDSTGAWHS SVEMDLHIRMMSMQKPHQALAVTGAICTTRALSVEGAIPARIAKNHSTKVRLAHSSGI IETMVEPTGIKIVRTARRIMDGTVYTHGDYQMM*" gene 2567115..2568218 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" misc_feature 2568108..2568127 /Source="Nicolas_upshift_promotors" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2568114 /Source="Nicolas_upshifts" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts complement(2568465) /Source="Nicolas_upshifts" /id="D1374" /incds=0 /nref=123 /ntot=254 /MaxReadThrough="2.33762" /MaxDrop="7.47213" /score="6.31571576" /energy="-8.7" /TU="U2071" /idTUdmin="U2071" /TUdmin="-33" /isTUend="FALSE" CDS complement(2568491..2569324) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" /EC_number="3.2.1.132" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11065371, 11320136, 1664582, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11065371, 11320136, 1664582, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chitosanase" /protein_id="NP_390566.1" /db_xref="EnsemblGenomes-Gn:BSU26890" /db_xref="EnsemblGenomes-Tr:CAB14630" /db_xref="GOA:O07921" /db_xref="InterPro:IPR000400" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG11923" /db_xref="UniProtKB/Swiss-Prot:O07921" /translation="MKISMQKADFWKKAAISLLVFTMFFTLMMSETVFAAGLNKDQKR RAEQLTSIFENGTTEIQYGYVERLDDGRGYTCGRAGFTTATGDALEVVEVYTKAVPNN KLKKYLPELRRLAKEESDDTSNLKGFASAWKSLANDKEFRAAQDKVNDHLYYQPAMKR SDNAGLKTALARAVMYDTVIQHGDGDDPDSFYALIKRTNKKAGGSPKDGIDEKKWLNK FLDVRYDDLMNPANHDTRDEWRESVARVDVLRSIAKENNYNLNGPIHVRSNEYGNFVI K*" gene complement(2568491..2569324) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" misc_feature complement(2569354..2569373) /Source="Nicolas_upshift_promotors" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2569363) /Source="Nicolas_upshifts" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" promotor_-35 2569529..2569533 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2569544..2569766 /Source="Nicolas_S_feature" /locus_tag="new_2749037_2749259" /HighExp="Lbstat, M9-stat, B60, M0t90, M40t90, T1.30H, T2.0H, T3.0H, T2.30H, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97565800000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1013" upshifts 2569544 /Source="Nicolas_upshifts" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" promotor_-10 2569548..2569567 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2569767..2570030 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390567.1" /db_xref="EnsemblGenomes-Gn:BSU26900" /db_xref="EnsemblGenomes-Tr:CAB14631" /db_xref="GOA:O07917" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG12276" /db_xref="UniProtKB/Swiss-Prot:O07917" /translation="MAYVKATAILPEKLISEIQKYVQGKTIYIPKPESSHQKWGACSG TRKLIDDRNASIKKAFKNGKTIHQLSDEYHLSIETIKKIVYSK*" gene 2569767..2570030 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" downshifts 2570018 /Source="Nicolas_upshifts" /id="D1375" /incds=0 /nref=71 /ntot=223 /MaxReadThrough="1.7419" /MaxDrop="4.94534" /score="-1.04752822" /energy="-9.9" /TU="NA" /idTUdmin="U2072" /TUdmin="-10" /isTUend="TRUE" CDS 2570167..2570982 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390568.2" /db_xref="EnsemblGenomes-Gn:BSU26910" /db_xref="EnsemblGenomes-Tr:CAB14632" /db_xref="GOA:O07937" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12275" /db_xref="UniProtKB/Swiss-Prot:O07937" /translation="MTINNGTLQVPGANIHYQVRGSGPIILLVHGGGGDADKFHHVAN HLANWYTVVTYDRRGHSRSNLANQIEGYRVETHSDDAHRLLAKITNKPAYVFGSSSGA VIGLDLCIRHPEQVHVMIPHEPILLQLLHGNELKQAEQFMEDLKKNHRSEVIKLMSRL ETDEQSKAVLTKRLLGNSTYFTEYEIQGILSYTLDFEALKTVFTSSPMKILPAGGSAS RELFPYRCANALAEQLETEWVEFPGNHTGYTMYHKEFSERLHDMLEKEKKHTC*" gene 2570167..2570982 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" S_feature complement(2571317..2571389) /Source="Nicolas_S_feature" /locus_tag="new_2750810_2750882_c" /HighExp="BC, Lbstat, Sw, M40t90, M0t90, S2, BI, BT, S3, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1014" downshifts complement(2571360) /Source="Nicolas_upshifts" /id="D1376" /incds=0 /nref=44 /ntot=205 /MaxReadThrough="1.43644" /MaxDrop="4.78753" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2073" /TUdmin="-1" /isTUend="TRUE" CDS complement(2571390..2571746) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390569.2" /db_xref="EnsemblGenomes-Gn:BSU26920" /db_xref="EnsemblGenomes-Tr:CAB14633" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12274" /db_xref="UniProtKB/Swiss-Prot:O07934" /translation="MTKLKMLSMLTVMIASLFIFSSQALAVQYFTVSTSSGAPVNMRS GPGTNYPIMLSIPSGSRVPYYCYAYGTTVTGKYGTSNIWDQIQWKDSRGVVNIGYVSD TYVYTGSDGPVGYKCN*" gene complement(2571390..2571746) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" CDS complement(2571799..2572158) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390570.2" /db_xref="EnsemblGenomes-Gn:BSU26930" /db_xref="EnsemblGenomes-Tr:CAB14634" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12273" /db_xref="UniProtKB/Swiss-Prot:O07909" /translation="MNKLKRLSMLTVMIASVFIFSSHALAAQYYTVSTSSGAPVNMRS GPGTSWGIVTTIPSGTRIPIYCYKTGTTVTGKYGTSNIWNYTERTLASGEIVPGFVSD TYMYTGSDGPVVPKCSW*" gene complement(2571799..2572158) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" misc_feature complement(2572251..2572270) /Source="Nicolas_upshift_promotors" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2572261) /Source="Nicolas_upshifts" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" CDS complement(2572430..2572531) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513987.1" /translation="MIGEKGGVSMNREEAWIQGSSTLIELIGGNEAA*" gene complement(2572430..2572531) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" S_feature complement(2572571..2572673) /Source="Nicolas_S_feature" /locus_tag="new_2752064_2752166_c" /HighExp="M40t90, LBGstat, M40t45, M0t90, Lbstat, Lbtran, LBGtran, LPhT, ferm, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.575" /TUlongSig="NA" /TUlongPSig="NA" /label="S1015" downshifts complement(2572613) /Source="Nicolas_upshifts" /id="D1377" /incds=0 /nref=19 /ntot=188 /MaxReadThrough="2.12056" /MaxDrop="4.09264" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2074" /TUdmin=0 /isTUend="TRUE" CDS complement(2572674..2573060) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390571.1" /db_xref="EnsemblGenomes-Gn:BSU26940" /db_xref="EnsemblGenomes-Tr:CAB14635" /db_xref="GOA:O07918" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12272" /db_xref="UniProtKB/Swiss-Prot:O07918" /translation="MKLLQIRLLVNDFKKSVEFYKDSLGLPISWLENEMEYALFDNGE TKIELLSRETMAEIVGEEKKSLEGEAQSKFLLQFKVEDVDKTYDDLHEKGVKCENKPH DRKEWSARVAHFRDPDHNLIEIYKML*" gene complement(2572674..2573060) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" misc_feature complement(2573102..2573118) /Source="Nicolas_upshift_promotors" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2573118) /Source="Nicolas_upshifts" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" promotor_-35 2573251..2573257 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2573272..2573283 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2573272 /Source="Nicolas_upshifts" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" CDS 2573309..2573554 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390572.1" /db_xref="EnsemblGenomes-Gn:BSU26950" /db_xref="EnsemblGenomes-Tr:CAB14636" /db_xref="GOA:O07919" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG12271" /db_xref="UniProtKB/Swiss-Prot:O07919" /translation="MDHQTLAAHEAVDLHEIVNFKTLCIAKSKLMQGLVFDQELKDLM EKDVQQSIQDLTELQAVYERASFQAPVPQSRPTPIIN*" gene 2573309..2573554 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" CDS 2573572..2573940 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390573.1" /db_xref="EnsemblGenomes-Gn:BSU26960" /db_xref="EnsemblGenomes-Tr:CAB14637" /db_xref="GOA:O07949" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG12270" /db_xref="UniProtKB/Swiss-Prot:O07949" /translation="MNNDHLDPINSLNVPELADTTFAMDFLIRAKEGVRNTAVALTET ASPDVRALLRKQLMQGIAMHQEITELMISKKWFHPYELSEQYKLDQLSAKNTIMVGNM NLFPDETNRKGMFDRTPDEH*" gene 2573572..2573940 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" CDS 2573959..2575095 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" /EC_number="1.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7926692, 17586670; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (involving bacillithiol)" /protein_id="NP_390574.2" /db_xref="EnsemblGenomes-Gn:BSU26970" /db_xref="EnsemblGenomes-Tr:CAB14638" /db_xref="GOA:O06012" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR027399" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11902" /db_xref="UniProtKB/Swiss-Prot:O06012" /translation="MKAVTYQGIKNVVVKDVPDPKIEKSDDMIIKVTSTAICGSDLHL IHGFIPNMQEDYVIGHEPMGIVEEVGSGVTKLKKGDRVIIPFNIACGECFFCKNQLES QCDQSNDNGEMGAYFGYSGQTGGYPGGQAEYLRVPFANFTHFKIPESCEEPDEKLSVI ADAMTTGFWSVDNAGVKKGDTVIVLGCGPVGLFAQKFCWLKGAKRVIAVDYVNYRLQH AKRTNKVEIVNFEDHENTGNYLKEITKGGADVVIDAVGMDGKMSDLEFLASGLKLHGG TMSALVIASQAVRKGGTIQITGVYGGRYNGFPLGDIMQRNVNIRSGQAPVIHYMPYMF ELVSTGKIDPGDVVSHVLPLSEAKHGYDIFDSKMDDCIKVVLKP*" gene 2573959..2575095 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" CDS 2575114..2575311 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390575.1" /db_xref="EnsemblGenomes-Gn:BSU26980" /db_xref="EnsemblGenomes-Tr:CAB14639" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13780" /db_xref="UniProtKB/Swiss-Prot:O06011" /translation="MEYALHEVLEVQEMTAFKTLCLTKSKTMKALVSDPKLKEIMQQD VDITTRQLQEFASILSNAKQE*" gene 2575114..2575311 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" CDS 2575327..2575626 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390576.1" /db_xref="EnsemblGenomes-Gn:BSU26990" /db_xref="EnsemblGenomes-Tr:CAB14640" /db_xref="GOA:O06010" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG13779" /db_xref="UniProtKB/Swiss-Prot:O06010" /translation="MNPIIEYLTGMNVLTDQIIAMDLLISAKNGVRNYAMAATEAGTP EVKEVLIRHLEEALDMHEQLSSYMMEKGWYHPWNPDEQVKLNLKNIDTAIQLPTL*" gene 2575327..2575626 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" downshifts 2575617 /Source="Nicolas_upshifts" /id="D1378" /incds=0 /nref=11 /ntot=39 /MaxReadThrough="1.62449" /MaxDrop="3.8153" /score="-8.57687054" /energy="-10.7" /TU="NA" /idTUdmin="U2075" /TUdmin=0 /isTUend="TRUE" CDS complement(2575889..2576311) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 17962296, 19170879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 17962296, 19170879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulated by thiol-alkylation" /protein_id="NP_390578.2" /db_xref="EnsemblGenomes-Gn:BSU27000" /db_xref="EnsemblGenomes-Tr:CAB14642" /db_xref="GOA:O06008" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13777" /db_xref="UniProtKB/Swiss-Prot:O06008" /translation="MNIAQVAKQFGLTAATLRYYERVGLIPPVKRKDSGIRDYDEEDI KWIEFIKCMRNAGLSIEALIEYTTLFTEGDRTVEARKNILADERQRLIEKRKEIDETI KRLDTKIKDYDGKLRENEAKLKSRPKTESLHGSVEQRR*" gene complement(2575889..2576311) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" promotor_-35 2576309..2576312 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-35" promotor_-10 2576328..2576347 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-10" S_feature 2576343..2576493 /Source="Nicolas_S_feature" /locus_tag="new_2755836_2755986" /HighExp="Diami, dia15, dia5, H2O2, S8, Paraq, S5, G180, S6, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1016" upshifts 2576343 /Source="Nicolas_upshifts" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" promotor_-10 complement(2576346..2576365) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2576353) /Source="Nicolas_upshifts" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" promotor_-35 complement(2576379..2576386) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2576462..2576481) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-10" upshifts complement(2576470) /Source="Nicolas_upshifts" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" CDS 2576494..2576688 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" /EC_number="4.1.1.44" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17962296, 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxymuconolactone decarboxylase" /protein_id="YP_009513988.1" /db_xref="EnsemblGenomes-Gn:BSU27009" /db_xref="EnsemblGenomes-Tr:CAX52671" /db_xref="InterPro:IPR029032" /db_xref="UniProtKB/TrEMBL:C0H460" /translation="MANKHTAGREQLGEFAPKFAELHDDVLFGDIWAREEELSSRDRS MITVSALITDCFSAYKSGSF*" gene 2576494..2576688 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" promotor_-35 complement(2576496..2576503) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-35" promotor_-35 2576706..2576713 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-35" promotor_-10 2576729..2576748 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-10" upshifts 2576733 /Source="Nicolas_upshifts" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" S_feature 2576734..2576818 /Source="Nicolas_S_feature" /locus_tag="new_2756227_2756311" /HighExp="LBGstat, dia15, Diami, LPhT, LBGtran, dia5, M40t90, Lbtran, H2O2, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.987, 0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1017" CDS 2576819..2577868 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase; carbonyl stressresponse" /protein_id="NP_390579.2" /db_xref="EnsemblGenomes-Gn:BSU27010" /db_xref="EnsemblGenomes-Tr:CAB14643" /db_xref="GOA:C0SPA5" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12562" /db_xref="UniProtKB/Swiss-Prot:C0SPA5" /translation="MCNQHQTRVLSVSHAKAKFEQTTIERRGLRPHDVLIDIKFSGIC HSDIHSAFDEWGGGIFPMVPGHEIAGVVTAVGTKVTKLAVGDRVGVGCFVDSCGECEY CLNAEEQFCTKGVVQTYNSVDYDGNPTYGGYSQKIVVTDRFVVRIPDRLEMDVASPLL CAGITTYSPLKHWNVGPGKKVAIVGVGGLGHLAIQFAHAMGAEVTVLSRSMNKKEEAL ELGANHYFATSDPATFTALAGRFDVILNTVSANLDVDAYLSMLRIDGTLVSVGAPAKP DTYSVFSLIMGRRSIAGSLVGGIQETQEMLDFAAEHGIEPKIEVIGADQVDEAYERIL RSDVRYRFVIDISTL*" gene 2576819..2577868 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" promotor_-35 2577936..2577943 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2577958..2577977 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2577971 /Source="Nicolas_upshifts" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" CDS 2577999..2578508 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12775685, 17257049, 17933887, 24330391, 26774339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deglycase; general stress protecting enzyme; protects against methylglyoxal toxicity" /protein_id="NP_390580.2" /db_xref="EnsemblGenomes-Gn:BSU27020" /db_xref="EnsemblGenomes-Tr:CAB14644" /db_xref="GOA:O06006" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13776" /db_xref="UniProtKB/Swiss-Prot:O06006" /translation="MSKKIAVLVTDQFEDIEYTSPVKAYEEAGYSVVAIDLEAGKEVT GKHGEKVKIDKAISDVDASDFDALLIPGGFSPDLLRADDRPGEFAKAFVENKKPVFAI CHGPQVLIDTDLLKGKDITGYRSIRKDLINAGANYKDAEVVVSHNIVTSRTPDDLEAF NRESLNLLK*" gene 2577999..2578508 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" downshifts 2578477 /Source="Nicolas_upshifts" /id="D1379" /incds=0 /nref=178 /ntot=254 /MaxReadThrough="4.08169" /MaxDrop="5.1444" /score="24.8267602" /energy="-16.3" /TU="U2080" /idTUdmin="U2076" /TUdmin=528 /isTUend="FALSE" S_feature 2578522..2579627 /Source="Nicolas_S_feature" /locus_tag="new_2758015_2759120" /HighExp="Diami, dia5, Etha, dia15, LPhT, H2O2, Lbstat, Salt, Fru, Paraq" /AntisenseName="sacC" /AntisenseCor="0.18236909579254801" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.926" /label="S1018" CDS complement(2578550..2580583) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" /EC_number="3.2.1.7" /EC_number="3.2.1.65" /EC_number="3.2.1.80" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7646030, 8057358, 10217495, 12224641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7646030, 8057358, 10217495, 12224641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levanase" /protein_id="NP_390581.1" /db_xref="EnsemblGenomes-Gn:BSU27030" /db_xref="EnsemblGenomes-Tr:CAB14645" /db_xref="GOA:P05656" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="PDB:4AZZ" /db_xref="PDB:4B1L" /db_xref="PDB:4B1M" /db_xref="SubtiList:BG10320" /db_xref="UniProtKB/Swiss-Prot:P05656" /translation="MKKRLIQVMIMFTLLLTMAFSADAADSSYYDEDYRPQYHFTPEA NWMNDPNGMVYYAGEYHLFYQYHPYGLQWGPMHWGHAVSKDLVTWEHLPVALYPDEKG TIFSGSAVVDKNNTSGFQTGKEKPLVAIYTQDREGHQVQSIAYSNDKGRTWTKYAGNP VIPNPGKKDFRDPKVFWYEKEKKWVMVLAAGDRILIYTSKNLKQWTYASEFGQDQGSH GGVWECPDLFELPVDGNPNQKKWVMQVSVGNGAVSGGSGMQYFVGDFDGTHFKNENPP NKVLWTDYGRDFYAAVSWSDIPSTDSRRLWLGWMSNWQYANDVPTSPWRSATSIPREL KLKAFTEGVRVVQTPVKELETIRGTSKKWKNLTISPASHNVLAGQSGDAYEINAEFKV SPGSAAEFGFKVRTGENQFTKVGYDRRNAKLFVDRSESGNDTFNPAFNTGKETAPLKP VNGKVKLRIFVDRSSVEVFGNDGKQVITDIILPDRSSKGLELYAANGGVKVKSLTIHP LKKVWGTTPFMSNMTGWTTVNGTWADTIEGKQGRSDGDSFILSSASGSDFTYESDITI KDGNGRGAGALMFRSDKDAKNGYLANVDAKHDLVKFFKFENGAASVIAEYKTPIDVNK KYHLKTEAEGDRFKIYLDDRLVIDAHDSVFSEGQFGLNVWDATAVFQNVTKES*" gene complement(2578550..2580583) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" downshifts complement(2578575) /Source="Nicolas_upshifts" /id="D1380" /incds=0 /nref=14 /ntot=60 /MaxReadThrough="0.56875" /MaxDrop="5.09923" /score="-2.07442916" /energy="-14.2" /TU="NA" /idTUdmin="U2081" /TUdmin=0 /isTUend="TRUE" CDS complement(2580492..2580659) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513989.1" /translation="MPETDQLAQQSLLKVFKHEERSEGTNEKETDSSHDHVHPAVDYG IFGRCSRFKLL*" gene complement(2580492..2580659) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" S_feature complement(2580584..2580739) /Source="Nicolas_S_feature" /locus_tag="new_2760077_2760232_c" /HighExp="UNK1, Fru, B60, T0.30H, M40t90, M0t90, ferm, LPh, GM-0.2, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.886" /TUlongSig="NA" /TUlongPSig="NA" /label="S1019" CDS complement(2580740..2581567) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IID component" /protein_id="NP_390582.1" /db_xref="EnsemblGenomes-Gn:BSU27040" /db_xref="EnsemblGenomes-Tr:CAB14646" /db_xref="GOA:P26382" /db_xref="InterPro:IPR004704" /db_xref="SubtiList:BG10319" /db_xref="UniProtKB/Swiss-Prot:P26382" /translation="MEKEKRLTKKEIFSMFIRSNFLLGSFNFERVQAMGYCYVMIPAI KKLYGPGAKRNEALQRHLEWFNTHPWLTAPIFGVTAAMEEEMANNKGIDGKAISGMKI GLMGPIAGVGDPIFWGTIRPVLAALGASLALGGNIAGPLLFFFLLNAIRLSTKYYGLK YGYVKGMEILQDLAGNRIQKLTEGASILGLFVMGALVSKWTTINIPIVVSRIKDESGK VDVQTVQNVLDSIMPGALPLGLTLLVAWMLRKGVNPLLIICGIFVIGILGYWAGFLA* " gene complement(2580740..2581567) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" CDS complement(2581588..2582397) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIC component" /protein_id="NP_390583.1" /db_xref="EnsemblGenomes-Gn:BSU27050" /db_xref="EnsemblGenomes-Tr:CAB14647" /db_xref="GOA:P26381" /db_xref="InterPro:IPR004700" /db_xref="SubtiList:BG10318" /db_xref="UniProtKB/Swiss-Prot:P26381" /translation="MSSLQIILLLIIAAITGIASVLDEGQTHRPLVACTLVGLVLGDL KTGIILGGTLELMALGWMNVGLAMAPDTAIASVISTILVITADQGIGEGIAVAVALAA AGQALTIFVRTITVFFIHRADQYAKAGNIKGIEIMHITAMVFQALRVMIPTLIVALIS VSAVQAFLGNIPDVITKGLQIGGGIIVVVGYAMVINMMNIPYLKPFFYIGFLLAAFTD FNLVGFGALGLCLALLYQQVMQKQSAHGAVAAASDSGSVAVYDDDDDDLDA*" gene complement(2581588..2582397) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" CDS complement(2582414..2582902) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" /EC_number="2.7.1.202" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 9622354, 10589728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 9622354, 10589728; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIB component" /protein_id="NP_390584.1" /db_xref="EnsemblGenomes-Gn:BSU27060" /db_xref="EnsemblGenomes-Tr:CAB14648" /db_xref="GOA:P26380" /db_xref="InterPro:IPR004720" /db_xref="InterPro:IPR018455" /db_xref="InterPro:IPR036667" /db_xref="PDB:1BLE" /db_xref="SubtiList:BG10317" /db_xref="UniProtKB/Swiss-Prot:P26380" /translation="MNIVLARIDDRFIHGQILTRWIKVHAADRIIVVSDDIAQDEMRK TLILSVAPSNVKASAVSVSKMAKAFHSPRYEGVTAMLLFENPSDIVSLIEAGVPIKTV NVGGMRFENHRRQITKSVSVTEQDIKAFETLSDKGVKLELRQLPSDASEDFVQILRNV TK*" gene complement(2582414..2582902) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" CDS complement(2582902..2583342) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" /EC_number="2.7.1.202" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIA component" /protein_id="NP_390585.1" /db_xref="EnsemblGenomes-Gn:BSU27070" /db_xref="EnsemblGenomes-Tr:CAB14649" /db_xref="GOA:P26379" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR013789" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10316" /db_xref="UniProtKB/Swiss-Prot:P26379" /translation="MISVIISGHGDFPIALKESSGMIFGEENNLIAVPFFKGEGIQTL QEKYHQALKDIPEEHEVLFLVDIFGGTPYNAAASFIAEDQRMDMAAGVNLPILLEVLS LREHLALKDLLNNLKAMSQQSFQVCSEHLEKVKTANQDTREDEL*" gene complement(2582902..2583342) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" downshifts 2583339 /Source="Nicolas_upshifts" /id="D1381" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="0.496260000000001" /MaxDrop="4.58461" /score="24.8267602" /energy="-16.3" /TU="NA" /idTUdmin="U2080" /TUdmin=3740 /isTUend="FALSE" misc_feature complement(2583379..2583397) /Source="Nicolas_upshift_promotors" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2583383) /Source="Nicolas_upshifts" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" CDS complement(2583532..2586339) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NifA/NtrC family)" /protein_id="NP_390586.2" /db_xref="EnsemblGenomes-Gn:BSU27080" /db_xref="EnsemblGenomes-Tr:CAB14650" /db_xref="GOA:P23914" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10677" /db_xref="UniProtKB/Swiss-Prot:P23914" /translation="MRRIDKIYHQLKHNFHDSTLDHLLKIQGNSAKEIAEQLKMERSN VSFELNNLVRSKKVIKIKTFPVRYIPVEIAEKLFNKKWDTEMMEVKDLQAFSGNSKQN HQHISTNPLELMIGAKGSLKKAISQAKAAVFYPPNGLHMLLLGPTGSGKSLFANRIYQ FAIYSDILKAGAPFITFNCADYYNNPQLLLSQLFGHKKGSFTGAAEDKAGLVEQANGG ILFMDEIHRLPPEGQEMLFYFIDSGSYNRLGESEHKRTSNVLFICATTENPSSALLKT FLRRIPMTIHIPSLEERSLNERVDLTTFLLGKEAERIKKNLSVHIDVYNALIHSAKFG NVGQLKSNVQLVCAHGFLHNLDRNEVIELTVRDLPDEIKQEWMSSSKNMQRSKAISEY VNITTIISPIVEDETTKIDEDLSFNLYHLIEEKVKTLMKEGLSKKDINQYILTDVHLH VRSFFHHQAFQKDNLLTFVEDDVIQMTKQLKEIAEHELDCTFDRKFIYFLSMHIDAFL KRGKQIDVLNTQETDEIRDTHVKEYRVAMIFKDKIQEYFKVAIPEIEVIYLTMLIHSI KSLKENKRVGIIVAAHGNSTASSMVEVATELLGSTPIAAVDMPLTVSPSDILECVAEK MKQVDEGEGVLMLVDMGSLAMLESRLEEKTGISIKTISNVTTSMVLDAVRKVNYLNLN LHAIYQSVTKDFIELWERQPAASGKKKALVSICTTGSGTAKKLEDILTTIVNKASDTP IHILTVSSIKLANSIKEIEKEYEILATVGTKDPKINAPHVSLEVLIEGEGEKLIQQAI TKGSISLSNGLNEANIIVRELCEDSLKKYLVFLNPHHVIDMLLEWLQTVQDELGVIFN NAVLIKVIMHTAFAFERVIKQNPIAFSEEEEINDQLKEMVYVTERTLAPYEEKLGLRI SDDEKLFIAAIFAEEVHGQLF*" gene complement(2583532..2586339) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" misc_feature complement(2586555..2586574) /Source="Nicolas_upshift_promotors" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2586561) /Source="Nicolas_upshifts" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" CDS 2586886..2587026 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513990.1" /translation="MTFLFYSAIQVESRVKNRATRHVTALKIVLKFKNKSIYSFKCYN IR*" gene 2586886..2587026 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" misc_feature 2587007..2587026 /Source="Nicolas_upshift_promotors" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2587017 /Source="Nicolas_upshifts" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" CDS 2587065..2588453 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17608695, 22084243; Product type t: transporter" /codon_start=1 /transl_table=11 /product="small amino acid permease" /protein_id="NP_390587.2" /db_xref="EnsemblGenomes-Gn:BSU27090" /db_xref="EnsemblGenomes-Tr:CAB14651" /db_xref="GOA:O06005" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12556" /db_xref="UniProtKB/Swiss-Prot:O06005" /translation="MIGNSSKDNFGQQQKLSRGLKNRHIQLMAIGGAIGTGLFLGSGK SIHFAGPSILFAYLITGVFCFFIMRSLGELLLSNAGYHSFVDFVRDYLGNMAAFITGW TYWFCWISLAMADLTAVGIYTQYWLPDVPQWLPGLLALIILLIMNLATVKLFGELEFW FALIKVIAILALIVTGILLIAKGFSAASGPASLNNLWSHGGMFPNGWHGFILSFQMVV FAFVGIELVGLTAGETENPQKVIPKAINQIPVRILLFYVGALFVIMCIYPWNVLNPNE SPFVQVFSAVGIVVAASLINFVVLTSAASAANSALFSTSRMVYSLAKDHHAPGLLKKL TSSNVPSNALFFSSIAILIGVSLNYLMPEQVFTLITSVSTICFIFIWGITVICHLKYR KTRQHEAKANKFKMPFYPLSNYLTLAFLAFILVILALANDTRIALFVTPVWFVLLIIL YKVQTRRGHKVK*" gene 2587065..2588453 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" downshifts 2588442 /Source="Nicolas_upshifts" /id="D1382" /incds=0 /nref=7 /ntot=120 /MaxReadThrough="0.96985" /MaxDrop="3.54068" /score="11.8049306" /energy="-13" /TU="NA" /idTUdmin="U2083" /TUdmin="-21" /isTUend="TRUE" S_feature complement(2588475..2588548) /Source="Nicolas_S_feature" /locus_tag="new_2767968_2768041_c" /HighExp="MG 120, LBGstat, MG 150, MG 90, S0, HPh, HiOs, GM-0.1, aero, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1020" downshifts complement(2588517) /Source="Nicolas_upshifts" /id="D1383" /incds=0 /nref=11 /ntot=121 /MaxReadThrough="1.79954" /MaxDrop="4.59487" /score="37.881034" /energy="-13" /TU="NA" /idTUdmin="U2084" /TUdmin=0 /isTUend="TRUE" CDS complement(2588549..2589181) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16098526, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_390588.1" /db_xref="EnsemblGenomes-Gn:BSU27100" /db_xref="EnsemblGenomes-Tr:CAB14652" /db_xref="GOA:O05406" /db_xref="InterPro:IPR001123" /db_xref="InterPro:IPR004778" /db_xref="SubtiList:BG12304" /db_xref="UniProtKB/Swiss-Prot:O05406" /translation="MHSLLAYIPIAAMMVIIPGADTMLVMKNTLRYGPKAGRYNILGL ATGLSFWTVIAILGLSVVIAKSVILFTTIKYLGAAYLIYLGVKSFFAKSMFSLDDMQS QAKNMASSPKRYYKTSFMQGSLSNILNPKTVLVYVTIMPQFINLNGNINQQLIILASI LTLLAVLWFLFLVYIIDYAKKWMKNSKFQKVFQKITGIILVGFGIKTGLS*" gene complement(2588549..2589181) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" downshifts complement(2588605) /Source="Nicolas_upshifts" /id="D1384" /incds=0 /nref=4 /ntot=132 /MaxReadThrough="4.46187" /MaxDrop="3.11632" /score="37.881034" /energy="-13" /TU="U2084" /idTUdmin="U2084" /TUdmin="-88" /isTUend="FALSE" promotor_-10 complement(2589235..2589254) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2589246) /Source="Nicolas_upshifts" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" promotor_-35 2589260..2589266 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2589269..2589276) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2589280..2589299 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2589285 /Source="Nicolas_upshifts" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" CDS 2589334..2590161 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator controlling amino acid export" /protein_id="NP_390589.1" /db_xref="EnsemblGenomes-Gn:BSU27110" /db_xref="EnsemblGenomes-Tr:CAB14653" /db_xref="InterPro:IPR002831" /db_xref="InterPro:IPR021586" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12303" /db_xref="UniProtKB/Swiss-Prot:O05405" /translation="MKENMLDILKNLNFTEYESKAYLALLQESPLTGYAVAKKSGVPR SKIYEVLESLVIRGDVFVSHGNTPQYVPVPAKELIKNRRLKAEEHFDQAEKYFEKFEQ TANDRENIWNITGRSEILEKVKACILSAKKRILLEIWKEDFKEIEAELKQAAEQGVIV TIIAYGDIVSDFANVYLHDMSSEITEEYDGRWLVYSGDDSEVVAGIVSLGNDSRAAWT MHVGLVMPITEVIIHDLYLMEILKKHRELLEESFGKNLIQLRRKFSIHSDFKKHYLE* " gene 2589334..2590161 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" downshifts 2590157 /Source="Nicolas_upshifts" /id="D1385" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="0.74814" /MaxDrop="5.12635" /score="6.64108595" /energy="-9.5" /TU="NA" /idTUdmin="U2085" /TUdmin=0 /isTUend="TRUE" promotor_-35 2590274..2590283 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2590296..2590311 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2590301 /Source="Nicolas_upshifts" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" CDS 2590357..2590857 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 21926231, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 21926231, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma(V))" /protein_id="NP_390590.1" /db_xref="EnsemblGenomes-Gn:BSU27120" /db_xref="EnsemblGenomes-Tr:CAB14654" /db_xref="GOA:O05404" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11974" /db_xref="UniProtKB/Swiss-Prot:O05404" /translation="MKKKQTTKALLVTCITDHKQDFYRLAFSYVKNQDDALDIVQESI KKALSSVETVRNPETIKSWFYKILVRTAIDFLRKQKKIRVMDDETIEFLSKGKEDHYK DTDLHEALDELPYRYKTIIILRFFEDLKLEEIAEITGENTNTVKTRLYRALKLMRIQL TKEDLS*" gene 2590357..2590857 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" CDS 2590857..2591714 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(V) factor" /protein_id="NP_390591.1" /db_xref="EnsemblGenomes-Gn:BSU27130" /db_xref="EnsemblGenomes-Tr:CAB14655" /db_xref="GOA:O05403" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="PDB:5JEN" /db_xref="SubtiList:BG12302" /db_xref="UniProtKB/Swiss-Prot:O05403" /translation="MDKRLQQLREEYKNVQIPKELDIIVEKALQQEPKKKRIVMWPTS AAIAAAILFTALVNINPDAAQAMSKIPVIGKIVKAITFIEIKEEKDQSSIDVKTPALS GLSNKELENSINEKYLKESQQLYKEFIQSTSKNKKGHLSIYSDYETVTDTPDLLSIRR NIETTQASSYTQSRYITIDKKNDILLTLKSLFKDERYIKVISQNIKEQMKQQMKEDPN KIYWLTDEDAEPFKTILPDQTFYITEDHKLVISFDEYEVAPGYMGVTEFTIPTGVISN LLVGERYIR*" gene 2590857..2591714 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" promotor_-10 complement(2591732..2591743) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2591751) /Source="Nicolas_upshifts" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2591758..2591764) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2591825..2593729 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1521192, 15661003, 21135105, 21586574, 21856855, 21926231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1521192, 15661003, 21135105, 21586574, 21856855, 21926231; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan O-acetyltransferase" /protein_id="NP_390592.1" /db_xref="EnsemblGenomes-Gn:BSU27140" /db_xref="EnsemblGenomes-Tr:CAB14656" /db_xref="GOA:O05402" /db_xref="InterPro:IPR002656" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12301" /db_xref="UniProtKB/Swiss-Prot:O05402" /translation="MYHKTQHHRYIPGLDGLRAFAVLSVITYHLNFNWANGGFIGVDI FFVLSGYLITSILLPAYGNDINLDFRDFWVRRIRRLLPAAYLMIFSTVVWVVLFDREL LHTVRGDAISSLFYMSNWWFIFHKLSYFDSFGSPSPLKNLWSLAIEEQFYIIWPMFLV VGMYIMKSRARLAAVISLLVLCSAVMMSVLYEPGGDPSRVYYGTDTRSFELLIGCALA LVWPMKRLSSNRLPSKLKHTLHATEFLAFCILVLCVYFTDEYEPFLYRGGMLFISVTA AILIACVCHPSSFLGNLLSWRPLRWLGTRSYGIYLWHYPVIVLSTPVQEIGNPVFWHI VLKVIVTCILAELSYHFIEKPIRTQGFRSFSRRVFIHRIKEWKTTSVISKMSIGFIIF AILIFAGGLSGLAGEQKHPTKWTYSSQETNADTSQASGDKKNAAADKKHNPEQKTTDS NQGQKENKDSGQETHKKKDTQSQQLKKPADTAKEVLAIGDSVMLDISSHLRQSFSNVT IDGKVGRQMSQALELAREYKSFNQPNKAVIIELGTNGYFTNSQIEQLLQSFSKAHIYL VNTRVPRQWESKVNESLQQQAHAHQNVTLVDWHTEALQHPEYFTPDGVHLVPKGAKTL TALIVQAMKS*" gene 2591825..2593729 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" promotor_-35 2593810..2593816 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2593832..2593850 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2593838 /Source="Nicolas_upshifts" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" CDS 2593863..2594153 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390593.1" /db_xref="EnsemblGenomes-Gn:BSU27150" /db_xref="EnsemblGenomes-Tr:CAB14657" /db_xref="GOA:O05401" /db_xref="InterPro:IPR025424" /db_xref="SubtiList:BG12300" /db_xref="UniProtKB/Swiss-Prot:O05401" /translation="MKGNEEHDIQKELKRYELFFKKRYKVLYTVNDFIIGAMFLVGSF FFFYDRLMSAGIWLFAIGSLLLLIRPTIRLIHDFHYRKHVEQQFKHQSSTDD*" gene 2593863..2594153 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" S_feature 2594154..2594269 /Source="Nicolas_S_feature" /locus_tag="new_2773647_2773762" /HighExp="Etha, Salt, LPhT, HiTm, G135, LBGstat, G180, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1021" promotor_-35 2594251..2594258 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2594271..2594396 /Source="Nicolas_S_feature" /locus_tag="new_2773764_2773889" /HighExp="Gly, G/S, Lbstat, C90, Pyr, LPhT, LoTm, Etha, T0.30H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1022" upshifts 2594271 /Source="Nicolas_upshifts" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" promotor_-10 2594272..2594290 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2594290..2594390 /gene="surF" /locus_tag="BSU_misc_RNA_82" /product="small untranslated RNA expressed under sporulation conditions (SurF-AbrB)" /experiment="publication(s) with functional evidences, PMID:20709900, 25790031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 25790031; Product type n: RNA" gene 2594290..2594390 /gene="surF" /locus_tag="BSU_misc_RNA_82" downshifts 2594353 /Source="Nicolas_upshifts" /id="D1386" /incds=0 /nref=7 /ntot=129 /MaxReadThrough="3.60641" /MaxDrop="5.24336" /score="25.0079309" /energy="-15.8" /TU="U2089" /idTUdmin="U2088" /TUdmin=16 /isTUend="TRUE" CDS complement(2594397..2597561) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" /EC_number="1.14.14.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11574077, 12775685" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077, 12775685; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP102A3" /protein_id="NP_390594.1" /db_xref="EnsemblGenomes-Gn:BSU27160" /db_xref="EnsemblGenomes-Tr:CAB14658" /db_xref="GOA:O08336" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12299" /db_xref="UniProtKB/Swiss-Prot:O08336" /translation="MKQASAIPQPKTYGPLKNLPHLEKEQLSQSLWRIADELGPIFRF DFPGVSSVFVSGHNLVAEVCDEKRFDKNLGKGLQKVREFGGDGLFTSWTHEPNWQKAH RILLPSFSQKAMKGYHSMMLDIATQLIQKWSRLNPNEEIDVADDMTRLTLDTIGLCGF NYRFNSFYRDSQHPFITSMLRALKEAMNQSKRLGLQDKMMVKTKLQFQKDIEVMNSLV DRMIAERKANPDENIKDLLSLMLYAKDPVTGETLDDENIRYQIITFLIAGHETTSGLL SFAIYCLLTHPEKLKKAQEEADRVLTDDTPEYKQIQQLKYIRMVLNETLRLYPTAPAF SLYAKEDTVLGGEYPISKGQPVTVLIPKLHRDQNAWGPDAEDFRPERFEDPSSIPHHA YKPFGNGQRACIGMQFALQEATMVLGLVLKHFELINHTGYELKIKEALTIKPDDFKIT VKPRKTAAINVQRKEQADIKAETKPKETKPKHGTPLLVLFGSNLGTAEGIAGELAAQG RQMGFTAETAPLDDYIGKLPEEGAVVIVTASYNGAPPDNAAGFVEWLKELEEGQLKGV SYAVFGCGNRSWASTYQRIPRLIDDMMKAKGASRLTAIGEGDAADDFESHRESWENRF WKETMDAFDINEIAQKEDRPSLSITFLSEATETPVAKAYGAFEGIVLENRELQTAAST RSTRHIELEIPAGKTYKEGDHIGILPKNSRELVQRVLSRFGLQSNHVIKVSGSAHMAH LPMDRPIKVVDLLSSYVELQEPASRLQLRELASYTVCPPHQKELEQLVSDDGIYKEQV LAKRLTMLDFLEDYPACEMPFERFLALLPSLKPRYYSISSSPKVHANIVSMTVGVVKA SAWSGRGEYRGVASNYLAELNTGDAAACFIRTPQSGFQMPNDPETPMIMVGPGTGIAP FRGFIQARSVLKKEGSTLGEALLYFGCRRPDHDDLYREELDQAEQDGLVTIRRCYSRV ENEPKGYVQHLLKQDTQKLMTLIEKGAHIYVCGDGSQMAPDVERTLRLAYEAEKAASQ EESAVWLQKLQDQRRYVKDVWTGM*" gene complement(2594397..2597561) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" downshifts complement(2594413) /Source="Nicolas_upshifts" /id="D1387" /incds=0 /nref=25 /ntot=213 /MaxReadThrough="2.3596" /MaxDrop="4.0425" /score="-9.99429269" /energy="-17.6" /TU="NA" /idTUdmin="U2091" /TUdmin=0 /isTUend="TRUE" promotor_-35 2595547..2595556 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2595570..2595589 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2595591 /Source="Nicolas_upshifts" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2597577..2598161) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11574077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for cypB" /protein_id="NP_390595.1" /db_xref="EnsemblGenomes-Gn:BSU27170" /db_xref="EnsemblGenomes-Tr:CAB14659" /db_xref="GOA:O08335" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR032551" /db_xref="SubtiList:BG12298" /db_xref="UniProtKB/Swiss-Prot:O08335" /translation="MISASSSKYDMIMKASVSLFTERGFDATTIPMIAERAHVGTGTI YRYFDSKETLVNVLFQESIQRFTEKLKQDVSELPVREGFHHVFCCLVQFTKESDYALF FLETKKDAHYLNHTSKKMIENLTQMLDDYFNKGKAEGVIRSLPSNVLIAIVLGAFLKI YQLVQTGDIEMDTDLITELEQCCWDAIKLHSSQK*" gene complement(2597577..2598161) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" CDS complement(2598384..2598926) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390596.1" /db_xref="EnsemblGenomes-Gn:BSU27180" /db_xref="EnsemblGenomes-Tr:CAB14660" /db_xref="GOA:O05400" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12297" /db_xref="UniProtKB/Swiss-Prot:O05400" /translation="MLENRLYKRSDFWKLFSRKYKLTKTIEHMMIDSIDIQENDRILE IGIGNGTVFKSITKKLKKGSLKSIDPSKRKVRQISRANRKNMGNGEVFHGYPEDIPFD DRTFNKVFSLHTVQSCTDIRLALREIYRVLQIDGRFYISIDTNTGEKEKTYIQLLKDQ HFRDLSVIRRASCLCIVAVK*" gene complement(2598384..2598926) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" S_feature complement(2598927..2599012) /Source="Nicolas_S_feature" /locus_tag="new_2778420_2778505_c" /HighExp="T-0.40H, Salt, T0.30H, Heat, T0.0H, Etha, T-1.10H, T-1.40H, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1023" promotor_-10 complement(2599010..2599025) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2599012) /Source="Nicolas_upshifts" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" promotor_-35 complement(2599038..2599047) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2599081..2599297) /Source="Nicolas_S_feature" /locus_tag="new_2778574_2778790_c" /HighExp="S7, S8, S6, LPhT, BT, LBGstat, S5, B36, G/S, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99909999999999999" /TUshortSig="SigK, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1024" CDS complement(2599115..2599273) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513991.1" /translation="MMNDYQKRLPSIGHGYASMPHSFKHGYGNPFRQQRLMAMQQQRL YVFPYHWH*" gene complement(2599115..2599273) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" downshifts complement(2599124) /Source="Nicolas_upshifts" /id="D1388" /incds=0 /nref=34 /ntot=184 /MaxReadThrough="3.04168" /MaxDrop="7.65849" /score="23.6695072" /energy="-11.3" /TU="U2093" /idTUdmin="U2092" /TUdmin="-3" /isTUend="TRUE" promotor_-10 complement(2599295..2599314) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2599297) /Source="Nicolas_upshifts" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" S_feature complement(2599299..2599429) /Source="Nicolas_S_feature" /locus_tag="new_2778792_2778922_c" /HighExp="S7, S8, LPhT, S6, LBGstat, B36, BT, S5, Cold, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.893648" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1025" promotor_-35 complement(2599328..2599337) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2599430..2599579) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390597.1" /db_xref="EnsemblGenomes-Gn:BSU27190" /db_xref="EnsemblGenomes-Tr:CAB14661" /db_xref="InterPro:IPR012655" /db_xref="SubtiList:BG13819" /db_xref="UniProtKB/Swiss-Prot:O32027" /translation="MTINLFFLTLTIKKRFKSLEEFEREQQIEQIYDEMKESQLKHLY LTNWR*" gene complement(2599430..2599579) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" downshifts 2599573 /Source="Nicolas_upshifts" /id="D1389" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="1.96539" /MaxDrop="3.70444" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=4972 /isTUend="FALSE" S_feature complement(2599580..2599670) /Source="Nicolas_S_feature" /locus_tag="new_2779073_2779163_c" /HighExp="S7, LBGstat, Cold, S6, B36, LPhT, T-0.40H, LoTm, S8, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1026" S_feature complement(2599672..2599891) /Source="Nicolas_S_feature" /locus_tag="new_2779165_2779384_c" /HighExp="B60, B36, S7, BT, LBGstat, Cold, LoTm, LPhT, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52109300000000003" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1027" downshifts complement(2599715) /Source="Nicolas_upshifts" /id="D1390" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="7.23426" /MaxDrop="3.6023" /score="11.9275075" /energy="-19.6" /TU="U2093,U2094" /idTUdmin="U2094" /TUdmin="-440" /isTUend="FALSE" downshifts 2599837 /Source="Nicolas_upshifts" /id="D1391" /incds=0 /nref=16 /ntot=94 /MaxReadThrough="0.94778" /MaxDrop="4.28987" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=5236 /isTUend="FALSE" promotor_-10 complement(2599870..2599889) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2599891) /Source="Nicolas_upshifts" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" S_feature complement(2599893..2599968) /Source="Nicolas_S_feature" /locus_tag="new_2779386_2779461_c" /HighExp="Lbexp, dia0, dia5, G150, Cold, C30, Mt0, LBGexp, dia15, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115567" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1028" promotor_-35 complement(2599904..2599911) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2599969..2600769) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 24887098; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative formate/nitrite transporter" /protein_id="NP_390598.1" /db_xref="EnsemblGenomes-Gn:BSU27200" /db_xref="EnsemblGenomes-Tr:CAB14662" /db_xref="GOA:O05399" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG12296" /db_xref="UniProtKB/Swiss-Prot:O05399" /translation="MAFRKPDEIAEAAIEAGMKKIKLPLPSLLVLGFLGGAFIALGYL LDIRVIGDLPKEWGSLSSLIGAAVFPVGLILVVLAGAELITGNMMSVAMALFSRKISV KELAINWGIVTIMNLIGALFVAYFFGHLVGLTETGPYLEKTIAVAQGKLDMSFGKVLI SAIGCNWLVCLAVWLSFGAQDAAGKILGIWFPIMAFVAIGFQHVVANMFVIPAAIFAG SFTWGQFIGNIIPAFIGNVIGGAVFVGLIYFIAYHKKDRSRKEMKQVS*" gene complement(2599969..2600769) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" S_feature complement(2600838..2600991) /Source="Nicolas_S_feature" /locus_tag="new_2780331_2780484_c" /HighExp="Lbexp, dia0, dia5, Cold, G150, Etha, HiOs, Salt, C90, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1029" downshifts complement(2600881) /Source="Nicolas_upshifts" /id="D1392" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="6.01922" /MaxDrop="3.7673" /score="23.461824" /energy="-25" /TU="U2094,U2095" /idTUdmin="U2095" /TUdmin="-132" /isTUend="FALSE" promotor_-10 complement(2600982..2601001) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-10" upshifts complement(2600991) /Source="Nicolas_upshifts" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" promotor_-35 complement(2601016..2601022) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-35" CDS complement(2601032..2601400) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390599.1" /db_xref="EnsemblGenomes-Gn:BSU27210" /db_xref="EnsemblGenomes-Tr:CAB14663" /db_xref="InterPro:IPR018745" /db_xref="SubtiList:BG12295" /db_xref="UniProtKB/Swiss-Prot:O05398" /translation="MSKKIHEFNDIIRKLRKELFGKGPERIHTVFVENMAVSTLYGNL SASEQFIARTPEGREMVHAARTSLIQDLYSKQTPEGMEELMGAKLVHLFSDIKIEENI AVSVFVFDRKIDEQKEALQS*" gene complement(2601032..2601400) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" S_feature complement(2601401..2601497) /Source="Nicolas_S_feature" /locus_tag="new_2780894_2780990_c" /HighExp="T0.30H, LBGstat, T1.0H, T1.30H, G150, Lbexp, dia0, G180, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1030" promotor_-10 complement(2601483..2601502) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-10" promotor_-35 2601487..2601490 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2601503) /Source="Nicolas_upshifts" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" promotor_-10 2601506..2601525 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2601508 /Source="Nicolas_upshifts" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" S_feature 2601509..2601715 /Source="Nicolas_S_feature" /locus_tag="new_2781002_2781208" /HighExp="G150, Lbexp, dia0, Cold, dia5, G135, LBGstat, LBGexp, G180, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1031" promotor_-35 complement(2601518..2601522) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-35" CDS 2601716..2604658 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" /EC_number="1.17.1.9" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913079, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative formate dehydrogenase" /protein_id="NP_390600.1" /db_xref="EnsemblGenomes-Gn:BSU27220" /db_xref="EnsemblGenomes-Tr:CAB14664" /db_xref="GOA:Q795Y4" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG12294" /db_xref="UniProtKB/Swiss-Prot:Q795Y4" /translation="MMDVKSISVRVDGTEIQARAGATILDILNENGIEYPQICHVPEV DPIQTCDTCIVEANGKLVRSCATVAENGMSIDLSGNRVKEAQTEAMDRLLENHLLYCT VCDNNNGNCTLHNTAEMMGIEHQKYPYTPKEDPSCAVDMSHPFYRYDPNQCIACGQCV EVCQNLQVNETLSIDWERERPRVIWDEGVPINESSCVSCGQCVTVCPCNALMEKSMLG QAGFMTGIKEDVMEPMIDLVKNVEPGYGSIFAISEVEAAMRETRTKKTKTVCTFCGVG CSFEVWTKGRDILKIQPVSDAPVNAISTCVKGKFGWDFVNSKERITKPLIRKNGAFVE SSWEEALDLVASRLGSIKEQYGKGSVGFISSSKITNEENYVIQKLARQVFETNNVDNC SRYCQSPATDGLFRTVGMGGDAGTIKDIAKAGLVIIVGANPAEGHPVLATRVKRAHKL HGQKLIVADLRKNEMAERSDLFISPKQGTDQVWLMAVTKYMIDQGWHDQAFIDENVNY FEDYKETLKTYTLDYAERITGLSKENIIQIAEMIRDADGTCVLWGMGVTQNTGGSDTS AAISNLLLATGNYRRPGAGAYPLRGHNNVQGACDMGTLPGWLPGYQHITDDKARAKFE EAYGVEIDGKPGLDNIQMLHAIEEGKMKAMYLVGEDMALVDSNANHVHDILSSLDFFV VQDIFLSRTAQYADVVLPATPSLEKDGTFTNTERRVQRLYQALPTLGDAKPDWWIIQE VANRLGANWNYSHPSDIFSEMASLSPLFAKASYEVLEGWNSFLWGSFTGESTPLLYED GFNFPDKKARFALSDWTEPAAFPEEYDLHINNGRMLEHFHEGNMTNKSKGIQAKVPNV FVEISPELAQERGVCDGSLVRLVSPFGAVKLNALITDRVRKNELYLPMNSTDKESAIN FLTGPAADKRTNTPAYKQTKVRMEVLGGCETAPLPKTNPRNKKRHPQNGVEAERKWNR PGYVHLTD*" gene 2601716..2604658 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" CDS 2604677..2605159 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10913079" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390601.1" /db_xref="EnsemblGenomes-Gn:BSU27230" /db_xref="EnsemblGenomes-Tr:CAB14665" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG12293" /db_xref="UniProtKB/Swiss-Prot:O05396" /translation="MATPITTIKKETKTAEQIKLEKIEELKELLAENEDAVSKTMTLM NELNDLGIFDAATSMLRAKEDIAKIALGQVSREPVTNLINTMMAAGGALTKADPEFTA KLLESVMAGTEQAQSFLKEDKKVGILDLLKAMNDPDINRAVGFGLQFLKGMGKELREQ *" gene 2604677..2605159 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" downshifts 2605139 /Source="Nicolas_upshifts" /id="D1393" /incds=0 /nref=65 /ntot=196 /MaxReadThrough="1.1227" /MaxDrop="6.19465" /score="27.8496451" /energy="-11.2" /TU="NA" /idTUdmin="U2096" /TUdmin=0 /isTUend="TRUE" CDS complement(2605195..2605425) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17056751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390602.1" /db_xref="EnsemblGenomes-Gn:BSU27240" /db_xref="EnsemblGenomes-Tr:CAB14666" /db_xref="GOA:O05395" /db_xref="InterPro:IPR025418" /db_xref="SubtiList:BG12292" /db_xref="UniProtKB/Swiss-Prot:O05395" /translation="MNKNRMKSLKEDYKHFAFTLLAVSTFLYIGAVLPDQGLTLGQKS TMFLADCVFLAGAFFCADRSLIYKKRLEEADE*" gene complement(2605195..2605425) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" downshifts complement(2605215) /Source="Nicolas_upshifts" /id="D1394" /incds=0 /nref=60 /ntot=210 /MaxReadThrough="0.98344" /MaxDrop="5.84379" /score="15.2557797" /energy="-11.2" /TU="NA" /idTUdmin="U2097" /TUdmin=0 /isTUend="TRUE" S_feature complement(2605426..2605507) /Source="Nicolas_S_feature" /locus_tag="new_2784919_2785000_c" /HighExp="dia5, dia15, BT, Diami, B36, B60, nit, dia0, MG 10, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1032" CDS complement(2605508..2606647) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" /EC_number="4.4.1.2" /EC_number="4.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-lyase and homocysteine gamma-lyase for reverse transsulfuration pathway" /protein_id="NP_390603.1" /db_xref="EnsemblGenomes-Gn:BSU27250" /db_xref="EnsemblGenomes-Tr:CAB14667" /db_xref="GOA:O05394" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12291" /db_xref="UniProtKB/Swiss-Prot:O05394" /translation="MKKKTLMIHGGITGDEKTGAVSVPIYQVSTYKQPKAGQHTGYEY SRTANPTRTALEALVTELESGEAGYAFSSGMAAITAVMMLFNSGDHVVLTDDVYGGTY RVMTKVLNRLGIESTFVDTSSREEVEKAIRPNTKAIYIETPTNPLLKITDLTLMADIA KKAGVLLIVDNTFNTPYFQQPLTLGADIVLHSATKYLGGHSDVVGGLVVTASKELGEE LHFVQNSTGGVLGPQDSWLLMRGIKTLGLRMEAIDQNARKIASFLENHPAVQTLYYPG SSNHPGHELAKTQGAGFGGMISFDIGSEERVDAFLGNLKLFTIAESLGAVESLISVPA RMTHASIPRERRLELGITDGLIRISVGIEDAEDLLEDIGQALENI*" gene complement(2605508..2606647) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" CDS complement(2606649..2607572) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" /EC_number="2.5.1.47" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-synthase for the reverse transsulfuration pathway" /protein_id="NP_390604.1" /db_xref="EnsemblGenomes-Gn:BSU27260" /db_xref="EnsemblGenomes-Tr:CAB14668" /db_xref="GOA:O05393" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG12290" /db_xref="UniProtKB/Swiss-Prot:O05393" /translation="MTVITDITELIGNTPLLRLKNFDVPEGVAVYAKLEMMNPGGSIK DRLGDMLIRDALDSGKVKPGGVIIEATAGNTGIGLALSARKYGLKAIFCVPEHFSREK QQIMQALGASIIHTPRQDGMQGAIQKAIQLETEIENSYCVLQFKNRVNPSTYYKTLGP EMWEALDGNIHTFVAGAGSGGTFAGTASFLKEKNPAVKTVIVEPVGSILNGGEPHAHK TEGIGMEFIPDYMDKSHFDEIYTVTDENAFRLVKEAAEKEGLLIGSSSGAALYAALEE AKKASAGTNIVTVFPDSSDRYISKQIYEGGI*" gene complement(2606649..2607572) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" downshifts complement(2607565) /Source="Nicolas_upshifts" /id="D1395" /incds=0 /nref=16 /ntot=178 /MaxReadThrough="7.13056" /MaxDrop="3.40819" /score="0.994445584" /energy="-8.7" /TU="U2097,U2098,U2099" /idTUdmin="U2102" /TUdmin=1874 /isTUend="FALSE" S_feature complement(2607573..2607636) /Source="Nicolas_S_feature" /locus_tag="new_2787066_2787129_c" /HighExp="dia5, Diami, dia15, BT, B36, S6, LBGstat, S8, dia0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1033" CDS complement(2607637..2608332) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" /EC_number="3.2.2.9" /EC_number="3.2.2.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioadenosine / S-adenosylhomocysteine nucleosidase" /protein_id="NP_390605.1" /db_xref="EnsemblGenomes-Gn:BSU27270" /db_xref="EnsemblGenomes-Tr:CAB14669" /db_xref="GOA:O32028" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR010049" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG13800" /db_xref="UniProtKB/Swiss-Prot:O32028" /translation="MRLAVIGAMEEEVTILRNKLENAKTETIAHCEFTTGEYEGTEVI LLKSGIGKVNAAISTTLLLDRYKPDYVINTGSAGGFHHTLNVGDVVISTDVRHHDVDV TAFDYEYGQVPGLPAAYAADEKLISITEEAVSELDGIQVAKGTIATGDSFMNDPKRVE EVRARFSDLYAVEMEAAAVAQVCHQFKTPFVVIRALSDIAGKESHVSFDQFLEQAAVH STELVLKVIKRIH*" gene complement(2607637..2608332) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" promotor_-10 complement(2608072..2608091) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2608090) /Source="Nicolas_upshifts" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" promotor_-35 complement(2608104..2608113) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2608353..2608994) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 17056751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AdoMet-dependent methyltransferase" /protein_id="NP_390606.1" /db_xref="EnsemblGenomes-Gn:BSU27280" /db_xref="EnsemblGenomes-Tr:CAB14670" /db_xref="GOA:O32029" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023553" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13799" /db_xref="UniProtKB/Swiss-Prot:O32029" /translation="MGREFIPLFEDWAATYDQTVQGLDIQYKEAFRGYDHILDAIVRK SGTHVLEFGPGTGNLTAKLLDAGKTVFGIEPSPAMRKLASDKLSGRTEIVDGDFLTFP EPPFQADTIVSSYAFHHLTDEEKRAAIKQYGKYLHLHDKIVFADTVFENAQAYQQAID KARSQGFYQLANDLETEHYPTLDALKEMFTAEGFAVRFTQQNDFVWIMEAIKR*" gene complement(2608353..2608994) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" promotor_-10 complement(2608561..2608580) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2608580) /Source="Nicolas_upshifts" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" promotor_-35 complement(2608597..2608600) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2609046..2609055 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2609052..2609071) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2609058) /Source="Nicolas_upshifts" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" promotor_-10 2609068..2609087 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2609077..2609141 /Source="Nicolas_S_feature" /locus_tag="new_2788570_2788634" /HighExp="BT, S6, S7, S8, S5, B36, G/S, Pyr, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1034" upshifts 2609077 /Source="Nicolas_upshifts" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" promotor_-35 complement(2609087..2609090) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2609122..2609129 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2609143 /Source="Nicolas_upshifts" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" promotor_-10 2609145..2609162 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2609187..2609390 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390607.1" /db_xref="EnsemblGenomes-Gn:BSU27290" /db_xref="EnsemblGenomes-Tr:CAB14671" /db_xref="InterPro:IPR019686" /db_xref="SubtiList:BG13811" /db_xref="UniProtKB/Swiss-Prot:O32030" /translation="MNFQLDLIKDKVEFFEAASLQELEKKINTQIENNKAIMLRVKSV SHQTLVAEGRILYSAVVHFSAEA*" gene 2609187..2609390 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" downshifts 2609397 /Source="Nicolas_upshifts" /id="D1396" /incds=0 /nref=205 /ntot=257 /MaxReadThrough="1.11529" /MaxDrop="5.39095" /score="26.0850303" /energy="-14.2" /TU="NA" /idTUdmin="U2101" /TUdmin="-10" /isTUend="TRUE" CDS complement(2609427..2610128) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679248" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390608.1" /db_xref="EnsemblGenomes-Gn:BSU27300" /db_xref="EnsemblGenomes-Tr:CAB14672" /db_xref="GOA:O32031" /db_xref="InterPro:IPR009988" /db_xref="SubtiList:BG13798" /db_xref="UniProtKB/Swiss-Prot:O32031" /translation="MSNNQSRYENRDKRRKANLVLNILIAIVSILIVVVAANLFINSP SSKDVSKDSETAQKQESPASGKTEKKSDEDIKDSKKDTSDSEKDSEKSSDSDSKKDDS SSKKDDSDSDSSSDSAGDGLKDAKVTEGGSSSDVEKTYENPDWKAVGTEQTGEHAATY DSSSQDWAEMLKAISYATGVSTDNMTVLWLGNNGSPQDAKGKILDKATGNKYQVTITW VDEKGWKPTKVEKLK*" gene complement(2609427..2610128) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" downshifts complement(2609439) /Source="Nicolas_upshifts" /id="D1397" /incds=0 /nref=237 /ntot=265 /MaxReadThrough="1.64695" /MaxDrop="6.48551" /score="22.1367505" /energy="-14.2" /TU="NA" /idTUdmin="U2102" /TUdmin=0 /isTUend="TRUE" CDS complement(2610193..2611947) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14679248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein PBP4B" /protein_id="NP_390609.1" /db_xref="EnsemblGenomes-Gn:BSU27310" /db_xref="EnsemblGenomes-Tr:CAB14673" /db_xref="GOA:O32032" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13797" /db_xref="UniProtKB/Swiss-Prot:O32032" /translation="MKISKRMKLAVIAFLIVFFLLLLRLAEIQLFFTESFSKKKINLI QESVKQRTEEVLISDGRGSFLDRNGRALTGQSEPAVVLFPFLLTQDWPIKKVADILGM SEDDLRQTLGQAKKPVILQQKKIKTLSKQSITKINSLKYPGIYGVYMENEDKPSLASH TIGSTNQDPALLRKKYPDKESLPITTEIGTTGLERTFDEFLLPEQDTKLLYHVDGKGN PLFGMDVKYTAEANTFYPLQIKTTIDQSIQKAMEEVLDEQGLKKGGAVLLDIENSSVL GIVSKPDADVSRQNTLQNYMLTPIYPGSVFKTVIAAAAIENNMVKPSQTFNCNLNLYG EPGDDKGTLSFDESFAQSCNYTFTSLAEQLMKKDSSVIEDMSEKLALTDRAGWEGKLY HETDFRQLYNEKSGVIWGDEKDKSVKKAIAQTAIGQKNVKVTPLEVANMMATIARGGE KRQVKIAEQIEYKNGTTLVTFKDQKLKGETIDKYTSQQLQKILRRVVESPSGTGRRFQ DLPYTVAGKSGTAQTGKLSKEKETLYEKWFAGYFPADKPKYALVVLHMDTPGDKALTN SVFYDIVKKVHEIEINQK*" gene complement(2610193..2611947) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" misc_feature complement(2610221..2610240) /Source="Nicolas_upshift_promotors" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2610231) /Source="Nicolas_upshifts" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" promotor_-10 complement(2611262..2611277) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2611265) /Source="Nicolas_upshifts" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" promotor_-35 complement(2611290..2611299) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2611493..2611511) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2611507) /Source="Nicolas_upshifts" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" promotor_-35 2611526..2611533 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2611526..2611531) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2611548..2611567 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2611553 /Source="Nicolas_upshifts" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2612001..2612474) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10910724, 16014871, 16707701, 21515770, 28976965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10910724, 16014871, 16707701, 21515770, 28976965; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription elongation factor resolving backtracking / stalling" /protein_id="NP_390610.1" /db_xref="EnsemblGenomes-Gn:BSU27320" /db_xref="EnsemblGenomes-Tr:CAB14674" /db_xref="GOA:P80240" /db_xref="InterPro:IPR001437" /db_xref="InterPro:IPR006359" /db_xref="InterPro:IPR018151" /db_xref="InterPro:IPR022691" /db_xref="InterPro:IPR023459" /db_xref="InterPro:IPR028624" /db_xref="InterPro:IPR036805" /db_xref="InterPro:IPR036953" /db_xref="SubtiList:BG19019" /db_xref="UniProtKB/Swiss-Prot:P80240" /translation="MAQEKVFPMTAEGKQKLEQELEYLKTVKRKEVVERIKIARSFGD LSENSEYDSAKEEQAFVEGRVTTLENMIRNAKIIEDDGGSNVVGLGKTVTFVELPDGD EESYTIVGSAEADPFEGKISNDSPIAKSLLGKKVDEEVTVQTPGGEMLVKIVKIS*" gene complement(2612001..2612474) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" downshifts complement(2612008) /Source="Nicolas_upshifts" /id="D1398" /incds=0 /nref=130 /ntot=229 /MaxReadThrough="5.30316" /MaxDrop="4.90519" /score="34.2316821" /energy="-17" /TU="U2107" /idTUdmin="U2106" /TUdmin="-17" /isTUend="TRUE" S_feature complement(2612475..2612607) /Source="Nicolas_S_feature" /locus_tag="new_2791968_2792100_c" /HighExp="HPh, C90, dia5, dia15, Diami, H2O2, dia0, Etha, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1035" promotor_-10 complement(2612589..2612608) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2612607) /Source="Nicolas_upshifts" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" S_feature complement(2612609..2612717) /Source="Nicolas_S_feature" /locus_tag="new_2792102_2792210_c" /HighExp="HPh, G180, G135, LBGexp, dia0, Paraq, Oxctl, G150, LPh, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1036" promotor_-35 complement(2612622..2612629) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2612710..2612729) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2612717) /Source="Nicolas_upshifts" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" CDS complement(2612725..2613360) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" /EC_number="2.7.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 6208029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridine kinase" /protein_id="NP_390611.1" /db_xref="EnsemblGenomes-Gn:BSU27330" /db_xref="EnsemblGenomes-Tr:CAB14675" /db_xref="GOA:O32033" /db_xref="InterPro:IPR000764" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR026008" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12696" /db_xref="UniProtKB/Swiss-Prot:O32033" /translation="MGKNPVVIGIAGGSGSGKTSVTRSIYEQFKGHSILMIQQDLYYK DQSHLPFEERLNTNYDHPLAFDNDYLIEHIQDLLNYRPIEKPIYDYKLHTRSEETVHV EPKDVIILEGILVLEDKRLRDLMDIKLYVDTDADLRIIRRIMRDINERGRSIDSVIEQ YVSVVRPMHNQFVEPTKRYADIIIPEGGQNHVAIDLMVTKIQTILEQNAIL*" gene complement(2612725..2613360) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" promotor_-35 complement(2612745..2612749) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2612855..2612860 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2612876..2612894 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2612883 /Source="Nicolas_upshifts" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2613367..2614635) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase large subunit" /protein_id="NP_390612.1" /db_xref="EnsemblGenomes-Gn:BSU27340" /db_xref="EnsemblGenomes-Tr:CAB14676" /db_xref="GOA:O32034" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032525" /db_xref="SubtiList:BG13796" /db_xref="UniProtKB/Swiss-Prot:O32034" /translation="MTAVNDKISTIVNGKRVITKKPELLAPAGNLEKLKIAVHYGADA VFIGGQEYGLRSNADNFTIEEIAEGVEFAKKYGAKIYVTTNIFAHNENMDGLEDYLKA LGDANVAGIIVADPLIIETCRRVAPNVEVHLSTQQSLSNWKAVQFWKEEGLDRVVLAR ETSALEIREMKEKVDIEIESFIHGAMCIAYSGRCVLSNHMTARDSNRGGCCQSCRWDY DLYQTDGANAVALYGEEDAPFAMSPKDLKLIESIPKMIEMGIDSLKIEGRMKSIHYVA TVVSVYRKVIDAYCADPENFVIQKEWLEELDKCANRDTATAFFEGTPGYEEQMFGEHA KKTTYDFVGLVLNYDEDTQMVTLQQRNFFKKGDEVEFFGPEIENFTHTIETIWDEDGN ELDAARHPLQIVKFKLDKKIYPSNMMRKGK*" gene complement(2613367..2614635) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" CDS complement(2614654..2615583) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase small subunit" /protein_id="NP_390613.1" /db_xref="EnsemblGenomes-Gn:BSU27350" /db_xref="EnsemblGenomes-Tr:CAB14677" /db_xref="GOA:O32035" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG13795" /db_xref="UniProtKB/Swiss-Prot:O32035" /translation="MKKPELLVTPTSTADILPLIQAGATAFLVGEQRYGLRLAGEFSR EDVTKAVEIAHKEGAKVYVAVNAIFHNDKVGELGEYLAFLAEAGVDAAVFGDPAVLMA ARESAPDLKLHWSTETTGTNYYTCNYWGRKGAARSVLARELNMDSIVEIKENAEVEIE IQVHGMTCMFQSKRSLIGNYFEYQGKVMDIERKKKESGMFLHDKERDNKYPIFEDENG THIMSPNDVCIIDELEELIDAGIDSFKIDGVLKMPEYLIEVTKMYREAIDLCVENRDE YEAKKEDWIERIESIQPVNRKIDTGFFFKETVY*" gene complement(2614654..2615583) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" CDS complement(2615589..2616242) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" /EC_number="2.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA O-methyltransferase" /protein_id="NP_390614.1" /db_xref="EnsemblGenomes-Gn:BSU27360" /db_xref="EnsemblGenomes-Tr:CAB14678" /db_xref="GOA:O32036" /db_xref="InterPro:IPR002935" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13794" /db_xref="UniProtKB/Swiss-Prot:O32036" /translation="MTDRYEQINDYIEALLKPRPDNVKRLEAYAEEHHVPIMEKAGME VLLQILSVKQPKKILEIGTAIGYSAIRMALELPSAEIYTIERNEKRHEEAVNNIKEFQ LDDRIHVFYGDALELADAVHVTAPYDVIFIDAAKGQYQNFFHLYEPMLSPDGVIITDN VLFKGLVAEDYSKIEPKRRRRLVAKIDEYNHWLMNHPDYQTAIIPVGDGLAISKKKR* " gene complement(2615589..2616242) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" S_feature complement(2616243..2616347) /Source="Nicolas_S_feature" /locus_tag="new_2795736_2795840_c" /HighExp="LBGexp, G180, H2O2, G150, Paraq, Oxctl, G135, dia15, C30, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1037" promotor_-10 complement(2616329..2616348) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2616347) /Source="Nicolas_upshifts" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" promotor_-35 complement(2616364..2616368) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2616394..2617476) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved membrane associated protein" /protein_id="NP_390615.1" /db_xref="EnsemblGenomes-Gn:BSU27370" /db_xref="EnsemblGenomes-Tr:CAB14679" /db_xref="GOA:O34758" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13793" /db_xref="UniProtKB/Swiss-Prot:O34758" /translation="MYINQQKKSFFNKKRIILSSIVVLFLIIGGAFLYGKSLLEPVEK DSKTTVNINIPSGSSVSAIASILKKNDVIKSEKAFQYYVKYKGASGFQAGFYHLNKGM DLDAIIQKLTSGATGYAFQITVTEGAQLTQIAAAIADETKYSKKQVIAKLDDETFINQ LKKEFPDTVTNDVFNKNIKHPLEGYLFPATYPFNDPDTSLEDIIKAMIKQTNSYVETY KSEMKKNKVSVHKLLTMASLIEEEATEKADRHKIASVFYNRLKKKMPLQTDPTVLYAA GKHKDRVLYKDLEIDSPYNTYKNTGLTPGPIANAGMSSWEAALHPDKTDYLYFLAKSN GEVVFTKTLKEHNKAKEKYISSKNEK*" gene complement(2616394..2617476) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" downshifts complement(2616428) /Source="Nicolas_upshifts" /id="D1399" /incds=0 /nref=21 /ntot=144 /MaxReadThrough="3.5258" /MaxDrop="3.97301" /score="10.5327118" /energy="-11" /TU="U2110" /idTUdmin="U2111" /TUdmin=1173 /isTUend="FALSE" promotor_-10 complement(2617492..2617511) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2617512) /Source="Nicolas_upshifts" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" promotor_-35 complement(2617526..2617529) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2617602) /Source="Nicolas_upshifts" /id="D1400" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="2.55298" /MaxDrop="6.9121" /score="36.0941054" /energy="-15" /TU="NA" /idTUdmin="U2111" /TUdmin="-1" /isTUend="TRUE" CDS complement(2617607..2617888) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_390616.1" /db_xref="EnsemblGenomes-Gn:BSU27380" /db_xref="EnsemblGenomes-Tr:CAB14680" /db_xref="InterPro:IPR009711" /db_xref="SubtiList:BG13812" /db_xref="UniProtKB/Swiss-Prot:O34828" /translation="MEHGEKNITIVDDQGNEQLCEVLFTFENEEFGKSYVLYYPIESK DDEEVEILASSFTPNEDGENGELFPIETDEEWDMIEETLNTFLADEDEE*" gene complement(2617607..2617888) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" downshifts complement(2617667) /Source="Nicolas_upshifts" /id="D1401" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.68915" /MaxDrop="5.19246" /score="36.0941054" /energy="-15" /TU="U2111,U2113,U2114,U2115" /idTUdmin="U2111" /TUdmin="-66" /isTUend="FALSE" CDS complement(2617906..2618322) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 14512736, 16021622, 22720735, 23251031, 25545592; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pre-16S ribosomal RNA maturation enzyme" /protein_id="NP_390617.1" /db_xref="EnsemblGenomes-Gn:BSU27390" /db_xref="EnsemblGenomes-Tr:CAB14681" /db_xref="GOA:O34634" /db_xref="InterPro:IPR005227" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR037027" /db_xref="PDB:1VHX" /db_xref="SubtiList:BG13792" /db_xref="UniProtKB/Swiss-Prot:O34634" /translation="MRILGLDLGTKTLGVALSDEMGWTAQGIETIKINEAEGDYGLSR LSELIKDYTIDKIVLGFPKNMNGTVGPRGEASQTFAKVLETTYNVPVVLWDERLTTMA AEKMLIAADVSRQKRKKVIDKMAAVMILQGYLDSLN*" gene complement(2617906..2618322) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" promotor_-10 complement(2618154..2618172) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2618173) /Source="Nicolas_upshifts" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" promotor_-35 complement(2618188..2618193) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2618330..2618596) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_054589.1" /db_xref="EnsemblGenomes-Gn:BSU27400" /db_xref="EnsemblGenomes-Tr:CAE01464" /db_xref="InterPro:IPR009309" /db_xref="SubtiList:BG14184" /db_xref="UniProtKB/Swiss-Prot:Q7WY61" /translation="MSSFDKTMKFNFSDDSAETNVNEVLITVYDALQEKGYNPINQIV GYLLSGDPAYIPRHRDARNLIRKLERDELIEELVKSYLEQHKEA*" gene complement(2618330..2618596) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" promotor_-35 2618484..2618492 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2618507..2618526 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2618515..2619704 /Source="Nicolas_S_feature" /locus_tag="new_2798008_2799197" /HighExp="S6, C30, C90, S8, S7, Gly, G135, Fru, G180, M/G" /AntisenseName="alaS" /AntisenseCor="-0.27843994691040502" /AntisenseRegPval="-5.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1038" upshifts 2618515 /Source="Nicolas_upshifts" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" S_feature complement(2618597..2618657) /Source="Nicolas_S_feature" /locus_tag="new_2798090_2798150_c" /HighExp="LBGtran, LBGexp, G135, C90, G150, G180, LBGstat, Oxctl, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigA" /TUshortPSig="0.994, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1039" promotor_-10 complement(2618651..2618670) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2618657) /Source="Nicolas_upshifts" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" CDS complement(2618681..2621317) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" /EC_number="6.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12554667, 12682299, 17329819, 22720735, 25918376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanyl-tRNA synthetase" /protein_id="NP_390618.1" /db_xref="EnsemblGenomes-Gn:BSU27410" /db_xref="EnsemblGenomes-Tr:CAB14682" /db_xref="GOA:O34526" /db_xref="InterPro:IPR002318" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018162" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR018164" /db_xref="InterPro:IPR018165" /db_xref="InterPro:IPR023033" /db_xref="SubtiList:BG12563" /db_xref="UniProtKB/Swiss-Prot:O34526" /translation="MKHLTSAEVRQMFLDFFKEKGHAVEPSASLVPHEDPSLLWINSG VATLKKYFDGRVVPENPRIVNAQKAIRTNDIENVGKTARHHTFFEMLGNFSIGDYFKE EAITWAWEFLTSDKWIGFDKELLSVTVHPEDEEAYEFWAKKIGIPEERIIRLEGNFWD IGEGPSGPNTEIFYDRGEAYGNDPEDPELYPGGENDRYLEVWNLVFSEFNHNPDGTYT PLPKKNIDTGMGLERMVSVIQNVPTNFDTDLFVPIIKATESISGETYGKDNVKDTAFK VIADHIRTVAFAVSDGALPSNEGRGYVLRRLLRRAVRYAKTINIHRPFMFDLVPVVAE IMADFYPEVKEKADFIAKVIKTEEERFHETLNEGLAILSEMIKKEKDKGSSVISGADV FKLYDTYGFPVELTEEYAEDENMTVDHEGFEEEMNQQRERARNARQDVGSMQVQGGAL RDVTVESTFVGYSQTKADANIIVLLQDGQLIEEAHEGESVQIILDETPFYAESGGQIG DKGYLRSEQAVVRIKDVQKAPNGQHVHEGVVESGTVQKGLHVTAEVEDHMRSGVIKNH TATHLLHQALKDVLGTHVNQAGSLVTENRLRFDFSHFGQVTKEELEQIERIVNEKIWA SIPVSIDLKPIAEAKEMGAMALFGEKYGDIVRVVQVGDYSLELCGGCHVRNTAEIGLF KIVSESGIGAGTRRIEAVTGQGAYVEMNSQISVLKQTADELKTNIKEVPKRVAALQAE LKDAQRENESLLAKLGNVEAGAILSKVKEVDGVNVLAAKVNAKDMNHLRTMVDELKAK LGSAVIVLGAVQNDKVNISAGVTKDLIEKGLHAGKLVKQAAEVCGGGGGGRPDMAQAG GKQPEKLEEALASVEDWVKSVL*" gene complement(2618681..2621317) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" promotor_-35 complement(2618684..2618691) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2621083..2621101) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2621099) /Source="Nicolas_upshifts" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" promotor_-35 complement(2621115..2621122) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2621318..2621396) /Source="Nicolas_S_feature" /locus_tag="new_2800811_2800889_c" /HighExp="G150, LBGexp, G135, G180, Oxctl, LBGtran, Lbexp, Paraq, dia15, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1040" misc_RNA complement(2621397..2621604) /gene="tboA" /locus_tag="BSU_misc_RNA_40" /product="T-box riboswitch specific of alanine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" gene complement(2621397..2621604) /gene="tboA" /locus_tag="BSU_misc_RNA_40" promotor_-10 complement(2621612..2621631) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2621627) /Source="Nicolas_upshifts" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" promotor_-35 complement(2621646..2621653) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2621648..2622709) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_390619.1" /db_xref="EnsemblGenomes-Gn:BSU27420" /db_xref="EnsemblGenomes-Tr:CAB14683" /db_xref="GOA:O34472" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13791" /db_xref="UniProtKB/Swiss-Prot:O34472" /translation="MLQKPVQLLLWVAICLLVLLTVYVFFMLDMLWSPFWLVIKTIFI PLIISIFISYLLLPVTEWLHGKGLPRTLSILVIYVLFFGGIGWALYKGVPVLIVQLTD LSENIPMFAETYNGLLLHVHNHTDDWPDGMHHRIDKMIRQTEAFFAGTIEGAISGIRN VLDYFLIAATIPFLVFYMVKDIELMKKTVWYLTPKSWRKRGSAFLRDVDDSLGDYIRG QLLVCLILGVIAGISFWVFGLPYPLILGLISGVTNVIPYFGPFIGAVPALLIAMTISV KAVLVVVITVFILQFMEGNILSPFIVGRSLKMHPVVIMLALLAGGELAGIVGMILAVP ATAVLKVMMIHFLRMRTEH*" gene complement(2621648..2622709) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" promotor_-35 2622618..2622623 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2622629..2622864 /Source="Nicolas_S_feature" /locus_tag="new_2802122_2802357" /HighExp="S5, S6, S4, S8, S3, S7, LoTm, BT, M9-stat, T5.0H" /AntisenseName="yrrI" /AntisenseCor="0.71790030040923003" /AntisenseRegPval="-43.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1041" upshifts 2622630 /Source="Nicolas_upshifts" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" promotor_-10 2622639..2622657 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2622726..2622737) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2622727) /Source="Nicolas_upshifts" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" promotor_-35 complement(2622751..2622757) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2622865..2623593 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (ATP-binding protein)" /protein_id="NP_390620.1" /db_xref="EnsemblGenomes-Gn:BSU27430" /db_xref="EnsemblGenomes-Tr:CAB14684" /db_xref="GOA:O34677" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11485" /db_xref="UniProtKB/Swiss-Prot:O34677" /translation="MITFQNVNKHYGDFHVLKQINLQIEKGEVVVIIGPSGSGKSTLL RCINRLESINEGVLTVNGTAINDRKTDINQVRQNIGMVFQHFHLYPHKTVLQNIMLAP VKVLRQSPEQAKETARYYLEKVGIPDKADAYPSQLSGGQQQRVAIARGLAMKPEVMLF DEPTSALDPEMIGEVLDVMKTLAKEGMTMVVVTHEMGFAKEVADRIVFIDEGKILEEA VPAEFYANPKEERARLFLSRILNH*" gene 2622865..2623593 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" downshifts complement(2623321) /Source="Nicolas_upshifts" /id="D1402" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="1.29649" /MaxDrop="3.29152" /score="-3.35464926" /energy="-5.4" /TU="NA" /idTUdmin="U2117" /TUdmin="-726" /isTUend="FALSE" CDS 2623615..2624436 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (glutamine-binding lipoprotein)" /protein_id="NP_390621.1" /db_xref="EnsemblGenomes-Gn:BSU27440" /db_xref="EnsemblGenomes-Tr:CAB14685" /db_xref="GOA:O34563" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11486" /db_xref="UniProtKB/Swiss-Prot:O34563" /translation="MKKIFSLALISLFAVILLAACGSKGSNGEASKESKKDTLAAIKD NDKIVFGVKTDTRLFGLKNPSSGEIEGFDIDIAKQIAKDILGDEKKAQFKEVTSKTRI PMLQNGDIDAIVATMTITEERKKEVDFSDVYFEAGQSLLVKKGSKIKSVENLGKGSKV LAVKGSTSSQNIREKAPEASVLEFENYAEAFTALKSGQGDALTTDNAILYGMADENKN YQLTGKPFTDEPYGIAVKKGQSALAKEINASLKKMKSDGRYDEIYKKWIKEDPAE*" gene 2623615..2624436 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" CDS 2624497..2625147 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390622.1" /db_xref="EnsemblGenomes-Gn:BSU27450" /db_xref="EnsemblGenomes-Tr:CAB14686" /db_xref="GOA:O34671" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11487" /db_xref="UniProtKB/Swiss-Prot:O34671" /translation="MNVSILFDNFSMYMDGFYHTLLASVIALAGSFVLGVAVAVMRIT VFKPLQWLGTAYVEFIRNIPLLLITFVFYFGLPNAGLRLDGFQAGTVALTIYTSAFIA EAIRAGIQSVSKGQMEAARSSGFTYSQAMLHIILPQAIKIVIPPLGNQFLNLVKNSSI LGVVAGLDLMYQADLVSSSTLVVFDVYIFVALFYLVLTIPLSIGVNYLEKRLEKSY*" gene 2624497..2625147 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" CDS 2625164..2625820 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390623.1" /db_xref="EnsemblGenomes-Gn:BSU27460" /db_xref="EnsemblGenomes-Tr:CAB14687" /db_xref="GOA:O34606" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11488" /db_xref="UniProtKB/Swiss-Prot:O34606" /translation="MDFIGAYSQEHLAFLWDGFLVTLYVAFISIILSFFFGLIAGTLR YAKVPVLSQLIAVLVETIRNLPLLLIIFFTFFALPEIGIKLEITAAAITALTIFESAM LSEIIRSGLKSIDKGQIEAARSSGLSYTQTLFFIVMPQALRRMVPPIVSQFISLLKDT SLAVVIALPELIHNAQIINGQSADGSYFFPIFLLAALMYFAVNYSLSLAARRLEVRQT *" gene 2625164..2625820 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" downshifts 2625819 /Source="Nicolas_upshifts" /id="D1403" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.21558" /MaxDrop="6.08472" /score="5.38937989" /energy="-11.7" /TU="NA" /idTUdmin="U2116" /TUdmin=0 /isTUend="TRUE" CDS complement(2625855..2625986) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097766.1" /db_xref="EnsemblGenomes-Gn:BSU27468" /db_xref="EnsemblGenomes-Tr:CAX52672" /db_xref="InterPro:IPR025029" /db_xref="UniProtKB/Swiss-Prot:C0H461" /translation="MNRTMTSLLAMGAGALVYRMATQSDMLNNRSMKRMRRRITKMF* " gene complement(2625855..2625986) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" downshifts complement(2625873) /Source="Nicolas_upshifts" /id="D1404" /incds=0 /nref=50 /ntot=77 /MaxReadThrough="1.58565" /MaxDrop="8.21989" /score="5.69801689" /energy="-11.7" /TU="NA" /idTUdmin="U2118" /TUdmin=0 /isTUend="TRUE" CDS complement(2626008..2626199) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097767.1" /db_xref="EnsemblGenomes-Gn:BSU27469" /db_xref="EnsemblGenomes-Tr:CAX52673" /db_xref="UniProtKB/Swiss-Prot:C0H462" /translation="MLICPNCKSKDIGKIGVNQYYCWGCFIELTVAKGKIATHQVEED GTLSSLDDLFSEDERSINF*" gene complement(2626008..2626199) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" CDS complement(2626211..2626735) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390624.1" /db_xref="EnsemblGenomes-Gn:BSU27470" /db_xref="EnsemblGenomes-Tr:CAB14688" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13790" /db_xref="UniProtKB/Swiss-Prot:O34402" /translation="MSLRRKAKPKPVQQKVVDHTLRTCHEVEGFPVYSERTSSYLGTI SDICFSLKGDCLGFILAQKRFLHHHHALLRACDISSIFDDRILASVSSEQLLPLPKSC FTYEQMKMKLVKSQEGDILGMLEDVYFCLDRGIIVAYELSDGFFSDLAGSKRQIQRAD SLVEVRKDEIVLNG*" gene complement(2626211..2626735) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" upshifts complement(2626322) /Source="Nicolas_upshifts" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" promotor_-10 complement(2626326..2626337) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2626352..2626358) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2626706..2626717) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2626712) /Source="Nicolas_upshifts" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" promotor_-35 complement(2626732..2626738) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2626793..2629189) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" /EC_number="3.1.11.5" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3537961, 11557815, 21170359, 22720735, 24443534, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3537961, 11557815, 21170359, 22720735, 24443534, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5'-3' helicase associated to SSB; exonuclease V" /protein_id="NP_390625.1" /db_xref="EnsemblGenomes-Gn:BSU27480" /db_xref="EnsemblGenomes-Tr:CAB14689" /db_xref="GOA:O34481" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR006345" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="InterPro:IPR029493" /db_xref="SubtiList:BG13789" /db_xref="UniProtKB/Swiss-Prot:O34481" /translation="MQQHPDQLKLEEEPYLKGTVNTVIYHNDTNLYTVLKVKVTETSE AIEDKAVSVTGYFPALQEEETYTFYGKIVTHPKFGLQFQAEHFKKEIPTTKEGIIQYL SSDLFEGIGKKTAEEIVKKLGDSAINKILADASVLYDVPRLSKKKADTLAGALQRHQG LEQIMISLNQFGFGPQLSMKIYQAYESETLEKIQENPYQLVKDVEGIGFGKADELGSR MGLSGNHPERVKAAILYTLETTCLSEGHTYIETEQLIIDTQSLLNQSAREGQRITEMD AANAIIALGENKDIVIEDGRCYFPSLFYAEQNVAKRVKHIASQTEYENQFPESEFLLA LGELEERMDVQYAPSQKEAIQKALSSPMLLLTGGPGTGKTTVIRGIVELYGELHGVSL DPSAYKKDEAFPIVLAAPTGRAAKRMSESTGLPAVTIHRLLGWNGAEGFTHTEDQPIE GKLLIIDEASMLDIWLANHLFKAIPDHIQIIIVGDEDQLPSVGPGQVLRDLLASQVIP TVRLTDIYRQAEGSSIVELAHQMKNGLLPNNLTAPTKDRSFIRCGGSQIKEVVEKVVA NALKKGYTAKDIQVLAPMYRGKAGINELNVMLQDILNPPKEKRRELKFGDVVYRTGDK ILQLVNQPENNVFNGDIGEITSIFYAKENTEKEDMAVVSFDGNEMTFTKKDFNQFTHA YCCSIHKSQGSEFPIVVLPVVKGYYRMLRRNLLYTAITRAKKFLILCGEEEALEWGVK NNDATVRQTSLKNRLSVQVEEMDAELEALQKELPFSVHDANIGMEGITPFDFMKEEQQ *" gene complement(2626793..2629189) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" downshifts complement(2626819) /Source="Nicolas_upshifts" /id="D1405" /incds=0 /nref=32 /ntot=211 /MaxReadThrough="2.07603" /MaxDrop="3.57113" /score="41.0323102" /energy="-10.8" /TU="NA" /idTUdmin="U2121" /TUdmin=0 /isTUend="TRUE" promotor_-35 2627039..2627045 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2627053 /Source="Nicolas_upshifts" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" promotor_-10 2627060..2627071 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2627073..2627422 /Source="Nicolas_S_feature" /locus_tag="new_2806566_2806915" /HighExp="S8, S5, S6, S7, S4, C30, nit, ferm, G135, T5.0H" /AntisenseName="yrrC" /AntisenseCor="-0.46935785055870999" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1042" downshifts complement(2627174) /Source="Nicolas_upshifts" /id="D1406" /incds=1 /nref=16 /ntot=163 /MaxReadThrough="4.93428" /MaxDrop="2.86437" /score="41.0323102" /energy="-10.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-355" /isTUend="FALSE" CDS complement(2629214..2629834) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11777911, 12594026, 18180259; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative tetratricopeptide repeat family protein" /protein_id="NP_390626.1" /db_xref="EnsemblGenomes-Gn:BSU27490" /db_xref="EnsemblGenomes-Tr:CAB14690" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR013105" /db_xref="InterPro:IPR019734" /db_xref="PDB:2Q7F" /db_xref="SubtiList:BG13788" /db_xref="UniProtKB/Swiss-Prot:O34452" /translation="MQEGDYEKAAEAFTKAIEENKEDAIPYINFANLLSSVNELERAL AFYDKALELDSSAATAYYGAGNVYVVKEMYKEAKDMFEKALRAGMENGDLFYMLGTVL VKLEQPKLALPYLQRAVELNENDTEARFQFGMCLANEGMLDEALSQFAAVTEQDPGHA DAFYNAGVTYAYKENREKALEMLDKAIDIQPDHMLALHAKKLIDPS*" gene complement(2629214..2629834) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" CDS complement(2629920..2631035) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" /EC_number="2.8.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-specific 2-thiouridylase" /protein_id="NP_390627.3" /db_xref="EnsemblGenomes-Gn:BSU27500" /db_xref="EnsemblGenomes-Tr:CAB14691" /db_xref="GOA:O35020" /db_xref="InterPro:IPR004506" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023382" /db_xref="SubtiList:BG13787" /db_xref="UniProtKB/Swiss-Prot:O35020" /translation="MEKRPEDTRVVVGMSGGVDSSVAALLLKEQGYDVIGIFMKNWDD TDENGFCTATEDYEDVIRVCNQIGIPYYAVNFEKQYYEKVFQYFLDEYKAGRTPNPDV LCNKEIKFKAFLEHALSLGADYLATGHYARVDRSGGKVRMLRGIDENKDQTYFLNQLT EDTLSKVMFPIGELQKSRVREIAKEAELATATKKDSTGICFIGERNFKTFLSQYLPAQ PGDMMTMDGEVKGRHDGLMYYTIGQRHGLGIGGSGEPWFAVGKDLEKNILYVDQGFHN PLLYSDKITATNISWVRSDIMKGEEISCTAKFRYRQEDHKVTVRMTGEGEAEVIFDEQ VRAVTPGQAVVFYDGEECLGGGTIDDVYKDGTKLWYV*" gene complement(2629920..2631035) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" downshifts complement(2629921) /Source="Nicolas_upshifts" /id="D1407" /incds=0 /nref=2 /ntot=69 /MaxReadThrough="6.45399" /MaxDrop="4.31641" /score="2.49091848" /energy="-7.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-3102" /isTUend="FALSE" CDS complement(2631066..2632205) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496536, 10930739, 12682299, 17064282, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496536, 10930739, 12682299, 17064282, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase involved in U34 tRNA thiolation" /protein_id="NP_390629.2" /db_xref="EnsemblGenomes-Gn:BSU27510" /db_xref="EnsemblGenomes-Tr:CAB14693" /db_xref="GOA:O34599" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG13809" /db_xref="UniProtKB/Swiss-Prot:O34599" /translation="MERIYLDHAATSPMDERVLEQMIPHFSGSFGNPSSIHSFGRESR KWVDEARAQIAAEIGAAEQEIIFTSGGTEADNLAIMGTALARKDLGRHIITTKIEHHA VLHTCEKLEGDGFDITYLDVDQNGRVSAKQVKEALRDDTILVTVMYGNNEVGTVQPIE EIGELLKEHKAYFHTDAVQAFGLLPIDVKNSHIDLLSVSGHKLNGPKGTGFLYASKDV KLSPLLFGGEQERKRRAGTENVPGIVGLKEAIKLSSEERDEKNEKYQSFKAIFADTLR DAGVAFEVNGDKEHSLPHVLNLYFPGVSVEALLVNLDMAGVAVSSGSACTAGSVLPSH VLTAMFGEESDRLTSSIRISFGLGNTAEQVKTAAKHVADVVKRLT*" gene complement(2631066..2632205) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" promotor_-10 complement(2631772..2631791) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2631784) /Source="Nicolas_upshifts" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" promotor_-35 complement(2631805..2631812) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2632224..2632640) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of cysteine biosynthesis" /protein_id="NP_390630.2" /db_xref="EnsemblGenomes-Gn:BSU27520" /db_xref="EnsemblGenomes-Tr:CAB14694" /db_xref="GOA:O34527" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2Y75" /db_xref="SubtiList:BG13813" /db_xref="UniProtKB/Swiss-Prot:O34527" /translation="MKISTKGRYGLTIMIELAKKHGEGPTSLKSIAQTNNLSEHYLEQ LVSPLRNAGLVKSIRGAYGGYVLGSEPDAITAGDIIRVLEGPISPVEVLEDEEPAKRE LWIRIRDAVKEVLDSTTLEDLASYTDGEQEAYMFYI*" gene complement(2632224..2632640) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" S_feature complement(2632641..2632738) /Source="Nicolas_S_feature" /locus_tag="new_2812134_2812231_c" /HighExp="Cold, T3.0H, G135, LBGexp, G180, G150, Salt, Lbexp, H2O2, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1043" promotor_-10 complement(2632723..2632742) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2632738) /Source="Nicolas_upshifts" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" promotor_-35 complement(2632758..2632761) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2632786..2632793 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2632807..2632826 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2632815 /Source="Nicolas_upshifts" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" CDS 2632843..2634108 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15743409, 17641684, 21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743409, 17641684, 21170359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-dependent ATPase active at replication forks" /protein_id="NP_390631.1" /db_xref="EnsemblGenomes-Gn:BSU27530" /db_xref="EnsemblGenomes-Tr:CAB14695" /db_xref="GOA:O34528" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR021886" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032423" /db_xref="SubtiList:BG13808" /db_xref="UniProtKB/Swiss-Prot:O34528" /translation="MKPLAYRMRPTKIEDIIGQQHLVAEDKIIGRMVQAKHLSSMILY GPPGIGKTSIATAIAGSTSIAFRKLNAVINNKKDMEIVAQEAKMSGQVILILDEVHRL DKGKQDFLLPYLENGMIILIGATTANPYHAINPAIRSRTQIFELEPLTPELIKQALER ALHDEHRGLGTYSVSIDDQAMEHFAHGCGGDVRSALNALELAVLSTKESADGEIHITL ETAEECLQKKSFSHDKDGDAHYDVLSAFQKSIRGSDANAALHYLARLIEAGDLESIAR RLLVIAYEDIGLASPQAGPRVLNAIQTAERVGFPEARIPLANAVIELCLSPKSNSAIL AIDEALADIRAGKIGDVPKHLKDAHYKGAQELGRGIDYKYPHNYDNGWVEQQYLPDPL KNKQYYKPKQTGKFESALKQVYDKLMKRK*" gene 2632843..2634108 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" downshifts 2634107 /Source="Nicolas_upshifts" /id="D1408" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="1.09429" /MaxDrop="4.5261" /score="14.6665846" /energy="-12" /TU="NA" /idTUdmin="U2123" /TUdmin="-7" /isTUend="TRUE" CDS complement(2634150..2634914) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" /EC_number="6.1.-.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12177353, 20097860, 23242255, 27913733, 28671653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA threonylcarbamoyladenosine dehydratase (t(6)A37 dehydratase)" /protein_id="NP_390632.3" /db_xref="EnsemblGenomes-Gn:BSU27540" /db_xref="EnsemblGenomes-Tr:CAB14713" /db_xref="GOA:O32037" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13807" /db_xref="UniProtKB/Swiss-Prot:O32037" /translation="MLHQFSRNELAIGKEGLETLKNSTVAVLGVGGVGSFAAEALARS GVGRILLVDKDDVDITNVNRQLHALLSTVGQPKVDLMKARIADINPECEVIALKMFYT EETYEQFFDYGLDYVIDASDTICYKIHLMKECLKRDIPLISSMGAANKTDPTRFQIAD ISKTHTDPIAKVVRTKLRKEGIKKGVQVIFSDESPIVIREDVRKEVGNDEAKIRKAKM PPSSNAFVPSVAGLIMGGHVVMDLLKDIEIKRVKDK*" gene complement(2634150..2634914) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" downshifts complement(2634168) /Source="Nicolas_upshifts" /id="D1409" /incds=0 /nref=246 /ntot=264 /MaxReadThrough="2.35294" /MaxDrop="7.20309" /score="44.7253801" /energy="-12" /TU="NA" /idTUdmin="U2125" /TUdmin=0 /isTUend="TRUE" misc_RNA complement(2634998..2635198) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" /product="6Sb RNA" /experiment="publication(s) with functional evidences, PMID:12177353, 15793584, 15811922, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 15793584, 15811922, 25576829, 26873600; Product type n: RNA" gene complement(2634998..2635198) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" downshifts complement(2635016) /Source="Nicolas_upshifts" /id="D1410" /incds=0 /nref=81 /ntot=303 /MaxReadThrough="7.44881" /MaxDrop="6.73892" /score="44.7253801" /energy="-12" /TU="U2125,U2127" /idTUdmin="U2125" /TUdmin="-848" /isTUend="FALSE" upshifts 2635185 /Source="Nicolas_upshifts" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 2635186..2635195 /Source="Nicolas_upshift_promotors" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2635196..2635215) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2635207) /Source="Nicolas_upshifts" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" promotor_-35 complement(2635228..2635235) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2635250..2637028) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" /EC_number="6.1.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12177353, 26804570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartyl-tRNA synthetase, promiscuous (also recognizes tRNAasn)" /protein_id="NP_390633.1" /db_xref="EnsemblGenomes-Gn:BSU27550" /db_xref="EnsemblGenomes-Tr:CAB14714" /db_xref="GOA:O32038" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004115" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004524" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029351" /db_xref="SubtiList:BG12572" /db_xref="UniProtKB/Swiss-Prot:O32038" /translation="MFGRTYYCGDITEKAIGESVTLKGWVQKRRDLGGLIFIDLRDRT GIVQVVFNPDVSKEALAIAEGIRNEYVLDIQGKVVAREEGTVNPNLKTGAIEIHADGV NVLNAAKTPPFAISDQAEEVSEDVRLKHRYLDLRRPAMFQTMQLRHNVTKAVRSFLDE NGFLDIETPILTGSTPEGARDYLVPSRVHEGEFYALPQSPQLFKQLLMVSGIERYYQI ARCFRDEDLRADRQPEFTQIDIEMSFMSQEDIMSLAEEMMAKVMRETKGEELQLPLPR MTYDEAMNKYGSDKPDTRFDMLLTDVSDIVKDTEFKVFSSAVANGGVVKAINVKGGAG DYSRKDIDALGAFAANYGAKGLAWVKVEADGVKGPIAKFFDEEKQSKLIEALDAAEGD LLLFGADQFEVVAASLGALRLKLGKERGLIDEKLFNFLWVIDWPLLEHDPEEGRFYAA HHPFTMPVREDLELIETAPEDMKAQAYDLVLNGYELGGGSIRIFEKDIQEKMFALLGF SPEEAAEQFGFLLEAFEYGAPPHGGIALGLDRLVMLLAGRTNLRDTIAFPKTASASCL MTEAPGEVSDAQLDELHLSIKKKVKN*" gene complement(2635250..2637028) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" CDS complement(2637042..2638316) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" /EC_number="6.1.1.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28321488; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase" /protein_id="NP_390634.1" /db_xref="EnsemblGenomes-Gn:BSU27560" /db_xref="EnsemblGenomes-Tr:CAB14715" /db_xref="GOA:O32039" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR015807" /db_xref="InterPro:IPR033656" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG12605" /db_xref="UniProtKB/Swiss-Prot:O32039" /translation="MGYNIPRGTQDILPGESDRWQFVEQIMRDTCRTYQYKEIRTPIF EHTELFARGVGESTDIVQKEMYTFEDRKGRSLTLRPEGTAAAVRAFNENKLFANPVQP TKLYYVGPMFRYERPQTGRYRQFYQFGIEAIGSKDPAIDAEVMALAMSIYEKAGLENV KLVINSLGDQDSRKSYREALVKHFEPRIEEFCSDCQSRLHTNPLRILDCKKDRDHELM KSAPSILTYLNEESAAYFEKVKQYLNDLGISYEIDPNLVRGLDYYNHTAFEIMSNAEG FGAITTLAGGGRYDGLVEQIGGPEAPGIGFAMSIERLLAAIDAEKRELPVDKGIDCYI VTLGEKAKDYSVSLVYKLREAGISSEIDYENKKMKGQFKTADRLKARFIAILGEDELA QNKINVKDAQTGEQIEVALDEFIHVMKANQKG*" gene complement(2637042..2638316) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" misc_RNA complement(2638406..2638638) /gene="tboH" /locus_tag="BSU_misc_RNA_42" /product="T-box riboswitch controlling synthesis of histidine and aspartate tRNA ligases" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.3: Control" gene complement(2638406..2638638) /gene="tboH" /locus_tag="BSU_misc_RNA_42" downshifts complement(2638436) /Source="Nicolas_upshifts" /id="D1411" /incds=0 /nref=71 /ntot=180 /MaxReadThrough="7.0761" /MaxDrop="5.61082" /score="40.6097692" /energy="-23.7" /TU="U2127" /idTUdmin="U2128" /TUdmin=0 /isTUend="TRUE" promotor_-35 2638648..2638651 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2638662..2638681) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2638666..2638685 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2638668..2638952 /Source="Nicolas_S_feature" /locus_tag="new_2818161_2818445" /HighExp="H2O2, G135, G180, C30, G150, Paraq, Oxctl, dia15, LBGstat, LBGexp" /AntisenseName="yrzK" /AntisenseCor="-0.27832941694878799" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1044" upshifts 2638668 /Source="Nicolas_upshifts" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" upshifts complement(2638681) /Source="Nicolas_upshifts" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" promotor_-35 complement(2638696..2638703) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2638698..2638868) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390635.1" /db_xref="EnsemblGenomes-Gn:BSU27570" /db_xref="EnsemblGenomes-Tr:CAB14716" /db_xref="InterPro:IPR035378" /db_xref="SubtiList:BG13820" /db_xref="UniProtKB/Swiss-Prot:O32040" /translation="MKYHPKMGRAFHDGEANLHYSDHADPDTTGYLTETASEFGLMSK EAALRKNNRNKA*" gene complement(2638698..2638868) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" promotor_-10 complement(2638899..2638910) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-10" upshifts complement(2638916) /Source="Nicolas_upshifts" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" promotor_-35 complement(2638925..2638931) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-35" promotor_-35 2638928..2638935 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2638949..2638967 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2638954 /Source="Nicolas_upshifts" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" CDS 2639001..2640557 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" /EC_number="3.5.1.28" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetylmuramoyl-L-alanine amidase, family 3" /protein_id="NP_390636.1" /db_xref="EnsemblGenomes-Gn:BSU27580" /db_xref="EnsemblGenomes-Tr:CAB14717" /db_xref="GOA:O32041" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR017293" /db_xref="SubtiList:BG13806" /db_xref="UniProtKB/Swiss-Prot:O32041" /translation="MNKKYFVLIVCIIFTSALFPTFSSVTAAQGEAVIATDEMNVRSG PGLSYGITAEVKKGERYPILKEDGDWVQIQLGSGEKGWVVSWLITKEDQASTSSSGSS DTVTSTDPDLRMRSGPGTSYEVIGKFPQGSQASVIDKDSGWIKISYHSATGWVSSEYV TSGGSSSASDESDQTEDSGASTTGTVGVSSLNVRASASHDAAIITKLDRGTKLTVLNE KNGWAHIEVNGLKGWVASHYLLTSSVPADDSANAGSSSSAKKAYIMYGGTNLRSDAST SASIVERAAKGDSYTITGSKGSWYEIKLDNGQTAYVANWVVQTSKSAEEAGEPPVSDS PSGNGSLNNKTIIVDPGHGGKDSGTIGYSGKFEKNLTIKTAKLLASKLRSAGADVYVT RQDDTFVSLQSRVSTSHYRNADAFISIHYDSYADTSTRGSTAYYYSPAKDQELASDVH SEVVKRSSIPDRGVLFGDYYVLRENRQPAMLYELGYVSHPQEEAIVHSNSYQEKVTDG IESGLEKYFQ*" gene 2639001..2640557 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" downshifts 2640536 /Source="Nicolas_upshifts" /id="D1412" /incds=0 /nref=199 /ntot=249 /MaxReadThrough="2.10072" /MaxDrop="7.40599" /score="44.9570925" /energy="-9.9" /TU="U2126" /idTUdmin="U2129" /TUdmin="-2" /isTUend="TRUE" CDS complement(2640584..2640982) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15292242, 15525705, 16844682, 18700836, 28362257; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gly-tRNA(Ala) deacylase / D-Tyr-tRNATyr deacylase" /protein_id="NP_390637.2" /db_xref="EnsemblGenomes-Gn:BSU27590" /db_xref="EnsemblGenomes-Tr:CAB14718" /db_xref="GOA:O32042" /db_xref="InterPro:IPR003732" /db_xref="InterPro:IPR023509" /db_xref="SubtiList:BG13805" /db_xref="UniProtKB/Swiss-Prot:O32042" /translation="MDEEVVGQIGQGLMVLVGITHDDTEDDAAYLADKVVNLRIFDDS EGKMNLSLVDIGGEILSVSQFTLYGDTKKGRRPNYMNAAKPDKALGLYEKWNDLLREK GIKVETGTFGAMMDVQLTNSGPVTLIMDSK*" gene complement(2640584..2640982) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" downshifts complement(2640592) /Source="Nicolas_upshifts" /id="D1413" /incds=0 /nref=152 /ntot=267 /MaxReadThrough="2.01735" /MaxDrop="9.47739" /score="37.3693259" /energy="-9.9" /TU="NA" /idTUdmin="U2130" /TUdmin=0 /isTUend="TRUE" CDS complement(2641036..2643240) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" /EC_number="2.7.6.5" /EC_number="3.1.7.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTP pyrophosphokinase (RelA/SpoT)" /protein_id="NP_390638.2" /db_xref="EnsemblGenomes-Gn:BSU27600" /db_xref="EnsemblGenomes-Tr:CAB14719" /db_xref="GOA:O54408" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004811" /db_xref="InterPro:IPR007685" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR033655" /db_xref="SubtiList:BG12665" /db_xref="UniProtKB/Swiss-Prot:O54408" /translation="MANEQVLTAEQVIDKARSYLSDEHIAFVEKAYLYAEDAHREQYR KSGEPYIIHPIQVAGILVDLEMDPSTIAGGFLHDVVEDTDVTLDDLKEAFSEEVAMLV DGVTKLGKIKYKSQEEQQAENHRKMFVAMAQDIRVILIKLADRLHNMRTLKHLPQEKQ RRISNETLEIFAPLAHRLGISKIKWELEDTALRYLNPQQYYRIVNLMKKKRAERELYV DEVVNEVKKRVEEVNIKADFSGRPKHIYSIYRKMVLQNKQFNEIYDLLAVRILVNSIK DCYAVLGIIHTCWKPMPGRFKDYIAMPKPNMYQSLHTTVIGPKGDPLEVQIRTFEMHE IAEYGVAAHWAYKEGKAANEGATFEKKLSWFREILEFQNESTDAEEFMESLKIDLFSD MVYVFTPKGDVIELPSGSVPIDFSYRIHSEIGNKTIGAKVNGKMVTLDHKLRTGDIVE ILTSKHSYGPSQDWVKLAQTSQAKHKIRQFFKKQRREENVEKGRELVEKEIKNLDFEL KDVLTPENIQKVADKFNFSNEEDMYAAVGYNGITALQVANRLTEKERKQRDQEEQEKI VQEVTGEPKPYPQGRKREAGVRVKGIDNLLVRLSKCCNPVPGDDIVGFITKGRGVSVH REDCPNVKTNEAQERLIPVEWEHESQVQKRKEYNVEIEILGYDRRGLLNEVLQAVNET KTNISSVSGKSDRNKVATIHMAIFIQNINHLHKVVERIKQIRDIYSVRRVMN*" gene complement(2641036..2643240) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" promotor_-10 complement(2643269..2643288) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2643276) /Source="Nicolas_upshifts" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" S_feature complement(2643278..2643368) /Source="Nicolas_S_feature" /locus_tag="new_2822771_2822861_c" /HighExp="Cold, G135, G180, G150, H2O2, Paraq, Oxctl, C30, LBGexp, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="0.951, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 1" /label="S1045" promotor_-35 complement(2643303..2643310) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2643332 /Source="Nicolas_upshifts" /id="D1414" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="1.75679" /MaxDrop="3.54336" /score="0.486890657" /energy="-12.7" /TU="NA" /idTUdmin="U2126" /TUdmin=2772 /isTUend="FALSE" CDS complement(2643408..2643920) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" /EC_number="2.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 9383190, 15629952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 9383190, 15629952; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine phosphoribosyltransferase" /protein_id="NP_390639.1" /db_xref="EnsemblGenomes-Gn:BSU27610" /db_xref="EnsemblGenomes-Tr:CAB14720" /db_xref="GOA:O34443" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005764" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG12568" /db_xref="UniProtKB/Swiss-Prot:O34443" /translation="MDLKQYVTIVPDYPKEGVQFKDITTLMDKGDVYRYATDQIVEYA KEKQIDLVVGPEARGFIIGCPVAYALGVGFAPVRKEGKLPREVIKVDYGLEYGKDVLT IHKDAIKPGQRVLITDDLLATGGTIEATIKLVEELGGVVAGIAFLIELSYLDGRNKLE DYDILTLMKY*" gene complement(2643408..2643920) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" downshifts complement(2643413) /Source="Nicolas_upshifts" /id="D1415" /incds=0 /nref=39 /ntot=228 /MaxReadThrough="5.36411" /MaxDrop="4.05036" /score="2.83935873" /energy="-6.8" /TU="U2131,U2132,U2133" /idTUdmin="U2131" /TUdmin="-115" /isTUend="FALSE" CDS complement(2643926..2646286) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21087930, 21170359, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21087930, 21170359, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="single-strand DNA-specific exonuclease" /protein_id="NP_390640.1" /db_xref="EnsemblGenomes-Gn:BSU27620" /db_xref="EnsemblGenomes-Tr:CAB14721" /db_xref="GOA:O32044" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR004610" /db_xref="InterPro:IPR018779" /db_xref="SubtiList:BG13804" /db_xref="UniProtKB/Swiss-Prot:O32044" /translation="MLASKMRWEIQRPDQDKVKSLTEQLHITPLVASLLVKRGFDTAE SARLFLHTKDADFYDPFEMKGMKEAADRIKQAISQQEKIMIYGDYDADGVTSTSVMLH TLQKLSAQVDFYIPDRFKEGYGPNEQAFRSIKERGFSLIITVDTGIAAVHEAKVAKEL GLDVIITDHHEPGPELPDVRAIVHPKQPGCTYPFKELAGVGVAFKLAHALLGELPDEL LDLAAIGTIADLVPLHDENRLIATLGLERLRRTNRLGLKELIKLSGGDIGEANEETVG FQLAPRLNAVGRIEQADPAVHLLMSEDSFEAEELAAEIDQLNKERQKMVSKMTDEAIE MVEQQGLDQTAIVVAKAGWNPGVVGIVASKLVDRFYRPAIVLGIDEEKGIAKGSARSI RGFNLFESLSECRDILPHFGGHPMAAGMTLKAEDVPDLRSRLNEIADNTLTEEDFIPV QEVDLVCGVEDITVESIAEMNMLSPFGMLNPKPHVLVENAVLEDVRKIGANKTHVKMT IRNESSQLDCVGFNKGELQEGIVPGSRISIVGEMSINEWNNRKKPQLMIKDAAVSEWQ LFDLRGKRTWEDTVSALPSAKRAIVSFKEDSTTLLQTEDLRREVHVISSKDQAKAFDL DGAYIVLLDPPPSLDMLARLLEGKAPERIYFIFLNHEDHFLSTFPARDHFKWYYAFLL KRGAFDVKKHGSELAKHKGWSVETINFMTKVFFDLGFVKIENGVLSVVSGAKKRDLTD SQTYQAKQQLMELDQKLNYSSAEELKEWLNKLMKQDSEAYESTRRT*" gene complement(2643926..2646286) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" promotor_-10 complement(2644390..2644409) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2644398) /Source="Nicolas_upshifts" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" promotor_-35 complement(2644423..2644432) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-35" promotor_-10 complement(2646300..2646319) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2646311) /Source="Nicolas_upshifts" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" promotor_-35 complement(2646334..2646340) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2646353..2646676) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390641.1" /db_xref="EnsemblGenomes-Gn:BSU27630" /db_xref="EnsemblGenomes-Tr:CAB14722" /db_xref="GOA:O32045" /db_xref="InterPro:IPR010445" /db_xref="SubtiList:BG13803" /db_xref="UniProtKB/Swiss-Prot:O32045" /translation="MNKQWTIIFALIFTLIVAIFAVINVRSVEVDYLFGRSEWPLILV ILGSVLMGALIVFSVGIFQVMKLKREIKTLRKENRTAIHKQEDTHLADQTDTQDASAM IEKKD*" gene complement(2646353..2646676) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" promotor_-10 complement(2646697..2646715) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2646708) /Source="Nicolas_upshifts" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" promotor_-35 complement(2646730..2646736) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-35" CDS complement(2646752..2647249) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative potassium transport accessory component" /protein_id="NP_390642.1" /db_xref="EnsemblGenomes-Gn:BSU27640" /db_xref="EnsemblGenomes-Tr:CAB14723" /db_xref="GOA:O32046" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13802" /db_xref="UniProtKB/Swiss-Prot:O32046" /translation="MRVRESELPGIGQKVEMITRNRDKISIIIHHDGRRELYYFDEND HEECVASVQFDDAEARQMSAILGGMAYKPKALEQVESALDDLIIEWCKAEAGAPAIHQ TIGDLNVGQEYHVTVIAIVKKNQDKQLNPSSETVIDEGDTLVISGEGTGLKRLIREKL TAKGA*" gene complement(2646752..2647249) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" S_feature complement(2647250..2647325) /Source="Nicolas_S_feature" /locus_tag="new_2826743_2826818_c" /HighExp="Oxctl, HiOs, G180, LBGexp, Paraq, G150, G135, H2O2, MG-0.2, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1046" promotor_-10 complement(2647319..2647338) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-10" upshifts complement(2647325) /Source="Nicolas_upshifts" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" promotor_-35 complement(2647352..2647359) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-35" CDS complement(2647407..2649620) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9694879, 15941986, 15995216, 16517687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9694879, 15941986, 15995216, 16517687; Product type t: transporter" /codon_start=1 /transl_table=11 /product="protein-export membrane protein" /protein_id="NP_390643.1" /db_xref="EnsemblGenomes-Gn:BSU27650" /db_xref="EnsemblGenomes-Tr:CAB14724" /db_xref="GOA:O32047" /db_xref="InterPro:IPR005665" /db_xref="InterPro:IPR005791" /db_xref="InterPro:IPR022645" /db_xref="InterPro:IPR022646" /db_xref="InterPro:IPR022813" /db_xref="SubtiList:BG12672" /db_xref="UniProtKB/Swiss-Prot:O32047" /translation="MKKGRLIAFFLFVLLIGTGLGYFTKPAANNITLGLDLQGGFEVL YDVQPVKKGDKITKDVLVSTVEALNRRANVLGVSEPNIQIEGNNRIRVQLAGVTNQNR AREILATEAQLSFRDANDKELLNGADLVENGAKQTYDSTTNEPIVTIKLKDADKFGEV TKKVMKMAPNNQLVIWLDYDKGDSFKKEVQKEHPKFVSAPNVSQELNTTDVKIEGHFT AQEAKDLASILNAGALPVKLTEKYSTSVGAQFGQQALHDTVFAGIVGIAIIFLFMLFY YRLPGLIAVITLSVYIYITLQIFDWMNAVLTLPGIAALILGVGMAVDANIITYERIKE ELKLGKSVRSAFRSGNRRSFATIFDANITTIIAAVVLFIFGTSSVKGFATMLILSILT SFITAVFLSRFLLALLVESRWLDRKKGWFGVNKKHIMDIQDTDENTEPHTPFQKWDFT SKRKYFFIFSSAVTVAGIIILLVFRLNLGIDFASGARIEVQSDHKLTTEQVEKDFESL GMDPDTVVLSGEKSNIGVARFVGVPDKETIAKVKTYFKDKYGSDPNVSTVSPTVGKEL ARNALYAVAIASIGIIIYVSIRFEYKMAIAAIASLLYDAFFIVTFFSITRLEVDVTFI AAILTIIGYSINDTIVTFDRVREHMKKRKPKTFADLNHIVNLSLQQTFTRSINTVLTV VIVVVTLLIFGASSITNFSIALLVGLLTGVYSSLYIAAQIWLAWKGRELKKDSAQ*" gene complement(2647407..2649620) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" downshifts complement(2647412) /Source="Nicolas_upshifts" /id="D1416" /incds=0 /nref=174 /ntot=249 /MaxReadThrough="4.49738" /MaxDrop="5.0013" /score="29.1843057" /energy="-17.8" /TU="U2137" /idTUdmin="U2137" /TUdmin="-1100" /isTUend="FALSE" promotor_-35 2649179..2649184 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2649198..2649217 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2649206 /Source="Nicolas_upshifts" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2649659..2649955) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19028902, 27059541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19028902, 27059541; Product type r: regulator" /codon_start=1 /transl_table=11 /product="post-transcriptional regulator" /protein_id="NP_390644.1" /db_xref="EnsemblGenomes-Gn:BSU27660" /db_xref="EnsemblGenomes-Tr:CAB14726" /db_xref="GOA:O32049" /db_xref="InterPro:IPR025716" /db_xref="SubtiList:BG13814" /db_xref="UniProtKB/Swiss-Prot:O32049" /translation="MEKHPADLYKDHVRPFLYSKLEEFKILGYDDVELESLWSYLTDK KWKKKTELSIYELASDILSVKIGEFMNYATVESFKTSNWLGSEEGQEALEELLR*" gene complement(2649659..2649955) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" downshifts 2649866 /Source="Nicolas_upshifts" /id="D1417" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.36122" /MaxDrop="2.33158" /score="-9.07145122" /energy="-8.4" /TU="NA" /idTUdmin="U2136" /TUdmin="-2508" /isTUend="FALSE" S_feature complement(2649956..2650034) /Source="Nicolas_S_feature" /locus_tag="new_2829449_2829527_c" /HighExp="LBGtran, Lbtran, C90, M40t45, HiOs, Lbexp, Cold, M0t45, UNK1, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigH" /TUlongPSig=1 /label="S1047" promotor_-35 2649996..2650001 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-35" promotor_-10 2650018..2650036 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-10" promotor_-10 complement(2650020..2650039) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-10" upshifts 2650020 /Source="Nicolas_upshifts" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" upshifts complement(2650034) /Source="Nicolas_upshifts" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" S_feature complement(2650036..2650954) /Source="Nicolas_S_feature" /locus_tag="new_2829529_2830447_c" /HighExp="S2, M9-stat, Lbstat, BC, T2.0H, T3.0H, T2.30H, T3.30H, Cold, M0t90" /AntisenseName="spoVB" /AntisenseCor="-8.5173616652496897E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1048" promotor_-35 complement(2650054..2650057) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-35" CDS 2650071..2651627 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1744050, 15292147, 15849754, 16850406, 17714441, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744050, 15292147, 15849754, 16850406, 17714441, 19648239; Product type t : transporter" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation); translocase with flippase function for peptidoglycan synthesis" /protein_id="NP_390645.1" /db_xref="EnsemblGenomes-Gn:BSU27670" /db_xref="EnsemblGenomes-Tr:CAB14727" /db_xref="GOA:Q00758" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR014249" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10778" /db_xref="UniProtKB/Swiss-Prot:Q00758" /translation="MAKQTFLKGTLILIAAGMVTRMLGFVNRVVIARFIGEEGVGLYM MAAPTFFLATTLTQFGLPVAISKLVAEASARGDHQKTKNILVMSLTITGVLSLIFTPL FLFFAPVMAETMLTDKRTLYPLLAITPVVPIIAISSVLRGYFQGKQNMNPLAMSQVLE QVVRISLVAVCTTIFLPYGIEYAAAGAMLSSVAGELASLLYLFVCFKYKKTIKIRKHF LQSIKNGKQTFTQLMSVSLPTTGSRFIGNLSWFFEPIVVAQSLAIAGVATVAATKQYG ELTGFAMTLLTLPSFITYSLSTALVPAISEGMEQKKLQVVEYRLEQAMRLCLLSGGIS VVILFVFADELMRVMYGSSGAAVFIKVMAPFFLLYYFQGPLQAVLQALNLAGAAMMNS LIGALVKTGLIFVLATRPSLGIMGAALAIVTGMVLVTLLHAATVSKVLPISIKIKEYA LSFAVIVICGFISSAIKQYISFGASEAVNLAGWIAASAAIYMILLLVFRLIKKDELRR IPIIGRLIIR*" gene 2650071..2651627 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" promotor_-10 complement(2650940..2650958) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-10" upshifts complement(2650954) /Source="Nicolas_upshifts" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" promotor_-35 complement(2650970..2650978) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-35" S_feature 2651628..2652392 /Source="Nicolas_S_feature" /locus_tag="new_2831121_2831885" /HighExp="S3, BT, S4, LoTm, S7, S8, T5.0H, T4.0H, M9-stat, T3.30H" /AntisenseName="yrbG" /AntisenseCor="0.65629957843767395" /AntisenseRegPval="-33.799999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1049" CDS complement(2651631..2652287) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390646.1" /db_xref="EnsemblGenomes-Gn:BSU27680" /db_xref="EnsemblGenomes-Tr:CAB14728" /db_xref="GOA:O32050" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG13786" /db_xref="UniProtKB/Swiss-Prot:O32050" /translation="MEELLTIAFRTVVLYFVILVIFRFMGKREIGELSILDLVVFIMM AEIAVLAIENVDDHLFHTILPMLVLMIIQVTLAYFSLKNRKVRQLLDGKPTIIIKYGK IDEEAMKSQRYNFDDLMVQLRENSIDRVADVSFAILEPSGKLTIVKKENSGEHRQLEM PLIIDGFIQTENLSRISKDRKWLLESLQKHGYTNPSDISFCSFTDGEIYIDEKDGHRT *" gene complement(2651631..2652287) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" promotor_-10 complement(2652306..2652317) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2652318) /Source="Nicolas_upshifts" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" promotor_-35 complement(2652331..2652337) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2652370..2652375 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2652391..2652409 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2652394 /Source="Nicolas_upshifts" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" CDS 2652422..2652874 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390647.1" /db_xref="EnsemblGenomes-Gn:BSU27690" /db_xref="EnsemblGenomes-Tr:CAB14729" /db_xref="GOA:O32051" /db_xref="InterPro:IPR023804" /db_xref="SubtiList:BG13815" /db_xref="UniProtKB/Swiss-Prot:O32051" /translation="MSDGFEQKEQKPFNTGREETIMEETKQVGKGILYGLIAIFSAML LTSLAVSLLLTATSLEESSFNWLITAISFLSLFIGGFISGGKGKERGWMIGALTALSF SLIILLFQYLGFGKTFTAEQLIFHLGFLGVCMLGGIFGVNMRGNRSST*" gene 2652422..2652874 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" downshifts 2652858 /Source="Nicolas_upshifts" /id="D1418" /incds=0 /nref=39 /ntot=61 /MaxReadThrough="1.45569" /MaxDrop="7.7199" /score="41.7975947" /energy="-15" /TU="NA" /idTUdmin="U2140" /TUdmin=0 /isTUend="TRUE" downshifts complement(2652913) /Source="Nicolas_upshifts" /id="D1419" /incds=0 /nref=188 /ntot=281 /MaxReadThrough="2.20451" /MaxDrop="7.91954" /score="33.5938356" /energy="-15" /TU="NA" /idTUdmin="U2141" /TUdmin="-1" /isTUend="TRUE" CDS complement(2652931..2653197) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10974125, 16166550, 21235483, 26790414; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the preprotein translocase" /protein_id="NP_390648.2" /db_xref="EnsemblGenomes-Gn:BSU27700" /db_xref="EnsemblGenomes-Tr:CAB14730" /db_xref="GOA:O32052" /db_xref="InterPro:IPR003849" /db_xref="SubtiList:BG13785" /db_xref="UniProtKB/Swiss-Prot:O32052" /translation="MTGTLGTLVPIILMFAVLYFLLIRPQQKQQKAVRQMQEELKKGD SVVTIGGLHGTVDSIDESKVVIKTGDNTRLTFDRRAIREVSAAE*" gene complement(2652931..2653197) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" CDS complement(2653234..2654379) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" /EC_number="2.4.2.29" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12123838, 14660578, 16199558, 16206323; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-guanine transglycosylase" /protein_id="NP_390649.1" /db_xref="EnsemblGenomes-Gn:BSU27710" /db_xref="EnsemblGenomes-Tr:CAB14731" /db_xref="GOA:O32053" /db_xref="InterPro:IPR002616" /db_xref="InterPro:IPR004803" /db_xref="InterPro:IPR036511" /db_xref="SubtiList:BG12686" /db_xref="UniProtKB/Swiss-Prot:O32053" /translation="MAEQPIRYEFIKECKQTGARLGKVHTPHGSFETPVFMPVGTLAT VKTMSPEELKAMDAGIILSNTYHLWLRPGQDIVKEAGGLHKFMNWDRAILTDSGGFQV FSLSKFRNIEEEGVHFRNHLNGDKLFLSPEKAMEIQNALGSDIMMAFDECPPYPAEYD YMKRSVERTSRWAERCLNAHNRQDEQGLFGIVQGGEYEDLRTQSAKDLISLDFPGYAI GGLSVGEPKDVMNRVLEFTTPLLPKDKPRYLMGVGSPDALIDGAIRGVDMFDCVLPTR IARNGTVFTAEGRLNMKNAKFERDFRPIDEECDCYTCKNYTRAYIRHLIRCNETFGLR LTTYHNLHFLLHLMEQVRQAIREDRLGDFREEFFERYGYNKPNAKSF*" gene complement(2653234..2654379) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" upshifts complement(2653286) /Source="Nicolas_upshifts" /id="U2141" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.432567432567433" /psig="0.164835164835165" /xcortree=2327 /SigmaFactorBS="tacacttaatggagcaggtaagacaggctattcgcgaggatc gtctgggtgatttcaGagaagagttctttgagcgttacggctataacaagccaaatgc g" /listShort="yrbF" /GFF_Attribute="listLong" misc_feature complement(2653289) /Source="Nicolas_upshift_promotors" /id="U2141" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.432567432567433" /psig="0.164835164835165" /xcortree=2327 /SigmaFactorBS="tacacttaatggagcaggtaagacaggctattcgcgaggatc gtctgggtgatttcaGagaagagttctttgagcgttacggctataacaagccaaatgc g" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2653330) /Source="Nicolas_upshifts" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" promotor_-10 complement(2653332..2653351) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2653366..2653371) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2654406..2655434) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" /EC_number="2.4.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15822125, 17083917, 10739928" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15822125, 17083917, 10739928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine tRNA ribosyltransferase-isomerase" /protein_id="NP_390650.1" /db_xref="EnsemblGenomes-Gn:BSU27720" /db_xref="EnsemblGenomes-Tr:CAB14732" /db_xref="GOA:O32054" /db_xref="InterPro:IPR003699" /db_xref="InterPro:IPR036100" /db_xref="PDB:1YY3" /db_xref="SubtiList:BG12662" /db_xref="UniProtKB/Swiss-Prot:O32054" /translation="MKVDLFDFELPERLIAQVPLEQRDASRLMVLDKHTGELTDSSFK HIISFFNEGDCLVLNNTRVLPARLFGTKEDTGAKVELLLLKQETGDKWETLAKPAKRV KKGTVVTFGDGRLKAICTEELEHGGRKMEFQYDGIFYEVLESLGEMPLPPYIKEQLDD KERYQTVYSKEIGSAAAPTAGLHFTEEILQQLKDKGVQIEFITLHVGLGTFRPVSADE VEEHNMHAEFYQMSEETAAALNKVRENGGRIISVGTTSTRTLETIAGEHDGQFKASSG WTSIFIYPGYEFKAIDGMITNFHLPKSSLIMLVSALAGRENILRAYNHAVEEEYRFFS FGDAMLII*" gene complement(2654406..2655434) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" CDS complement(2655464..2655664) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="YP_003097768.1" /db_xref="EnsemblGenomes-Gn:BSU27729" /db_xref="EnsemblGenomes-Tr:CAX52674" /db_xref="GOA:C0H463" /db_xref="InterPro:IPR021320" /db_xref="UniProtKB/Swiss-Prot:C0H463" /translation="MTEFPKIIMILGAVLLIIGAVLHFVGKMPGDIFVKKGNVTFFFP VVTCIIISVVLSILLNLFGRMK*" gene complement(2655464..2655664) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" CDS complement(2655657..2656661) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" /EC_number="3.1.22.4" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14701911, 15317759, 16267290, 19422832, 21600217, 24770420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase, ATP-dependent component" /protein_id="YP_054590.1" /db_xref="EnsemblGenomes-Gn:BSU27730" /db_xref="EnsemblGenomes-Tr:CAB14733" /db_xref="GOA:O32055" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004605" /db_xref="InterPro:IPR008823" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12669" /db_xref="UniProtKB/Swiss-Prot:O32055" /translation="MDERLVSSEADNHESVIEQSLRPQNLAQYIGQHKVKENLRVFID AAKMRQETLDHVLLYGPPGLGKTTLASIVANEMGVELRTTSGPAIERPGDLAAILTAL EPGDVLFIDEIHRLHRSIEEVLYPAMEDFCLDIVIGKGPSARSVRLDLPPFTLVGATT RVGLLTAPLRDRFGVMSRLEYYTQEELADIVTRTADVFEVEIDKPSALEIARRSRGTP RVANRLLRRVRDFAQVLGDSRITEDISQNALERLQVDRLGLDHIDHKLLMGMIEKFNG GPVGLDTISATIGEESHTIEDVYEPYLLQIGFIQRTPRGRIVTPAVYHHFQMEAPRYD *" gene complement(2655657..2656661) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" CDS complement(2656672..2657277) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" /EC_number="3.1.22.4" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16267290, 24770420" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16267290, 24770420; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase" /protein_id="NP_390652.1" /db_xref="EnsemblGenomes-Gn:BSU27740" /db_xref="EnsemblGenomes-Tr:CAB14734" /db_xref="GOA:O05392" /db_xref="InterPro:IPR000085" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR011114" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013849" /db_xref="InterPro:IPR036267" /db_xref="SubtiList:BG11973" /db_xref="UniProtKB/Swiss-Prot:O05392" /translation="MIEFVKGTIDYVSPQYIVIENGGIGYQIFTPNPFIYKERSQETI FTYHHIREDAFSLYGFSTREEKALFTKLLNVTGIGPKGALAILGSGDPGAVIQAIENE DEAFLVKFPGVGKKTARQIILDLKGKLADVVPEMIENLFNHEERLEKQTAETALEEAL EALRVLGYAEKEIKKVLPHLKEEIGLTTDQYVKKALQKLLK*" gene complement(2656672..2657277) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" promotor_-10 complement(2657296..2657315) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2657312) /Source="Nicolas_upshifts" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" S_feature complement(2657314..2657415) /Source="Nicolas_S_feature" /locus_tag="new_2836807_2836908_c" /HighExp="Etha, Heat, S8, S7, S4, S3, S6, S5, Salt, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1050" promotor_-35 complement(2657326..2657332) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2657416..2657928) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10931291, 16049010" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10931291, 16049010; Product type f: factor" /codon_start=1 /transl_table=11 /product="bypass of forespore C, intercompartmental signaling factor" /protein_id="NP_390653.1" /db_xref="EnsemblGenomes-Gn:BSU27750" /db_xref="EnsemblGenomes-Tr:CAB14735" /db_xref="GOA:O05391" /db_xref="InterPro:IPR015050" /db_xref="InterPro:IPR015071" /db_xref="PDB:2BW2" /db_xref="SubtiList:BG11917" /db_xref="UniProtKB/Swiss-Prot:O05391" /translation="MKRFSTAYLLLGILCSAAVFLIGAPSRALGAEVEHYEPLQVHVQ LEKVYLDGDVSIEHKHEKVFSMDDFWAAYAGWTLVEQKKGYVLFRKQMDDISPLSKVN GYIGVSDNGVISTFHGRPEPASEPIQSFFQIDLERLESHMQKNLLKGIPFRTKAEFED VIEHMKTYSG*" gene complement(2657416..2657928) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" promotor_-10 complement(2657957..2657968) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-10" upshifts complement(2657972) /Source="Nicolas_upshifts" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" CDS complement(2657976..2659283) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9099855, 14638426, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative catecholate siderophose exporter" /protein_id="NP_390654.2" /db_xref="EnsemblGenomes-Gn:BSU27760" /db_xref="EnsemblGenomes-Tr:CAB14736" /db_xref="GOA:O05390" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11922" /db_xref="UniProtKB/Swiss-Prot:O05390" /translation="MNTVHAKGNVLNKIGIPSHMVWGYIGVVIFMVGDGLEQGWLSPF LVDHGLSMQQSASLFTMYGIAVTISAWLSGTFVQTWGPRKTMTVGLLAFILGSAAFIG WAIPHMYYPALLGSYALRGLGYPLFAYSFLVWVSYSTSQNILGKAVGWFWFMFTCGLN VLGPFYSSYAVPAFGEINTLWSALLFVAAGGILALFFNKDKFTPIQKQDQPKWKELSK AFTIMFENPKVGIGGVVKTINAIGQFGFAIFLPTYLARYGYSVSEWLQIWGTLFFVNI VFNIIFGAVGDKLGWRNTVMWFGGVGCGIFTLALYYTPQLIGHQYWVLMIIACCYGAA LAGYVPLSALLPTLAPDNKGAAMSVLNLGSGLCAFIAPGIVSLFIGPLGAGGVIWIFA ALYFFSAFLTRFLTISEQSTDVYTEERFVRENVQTNFDKTVKQ*" gene complement(2657976..2659283) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" promotor_-35 complement(2657983..2657989) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-35" downshifts complement(2659237) /Source="Nicolas_upshifts" /id="D1420" /incds=0 /nref=2 /ntot=80 /MaxReadThrough="7.18585" /MaxDrop="3.0235" /score="-6.29978124" /energy="-14.3" /TU="U2145,U2146" /idTUdmin="U2146" /TUdmin="-1793" /isTUend="FALSE" promotor_-10 complement(2659307..2659325) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-10" upshifts complement(2659322) /Source="Nicolas_upshifts" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" promotor_-35 complement(2659340..2659346) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-35" CDS complement(2659354..2660379) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative inositol-related oxidoreductase" /protein_id="NP_390655.1" /db_xref="EnsemblGenomes-Gn:BSU27770" /db_xref="EnsemblGenomes-Tr:CAB14737" /db_xref="GOA:O05389" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR030827" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12280" /db_xref="UniProtKB/Swiss-Prot:O05389" /translation="MTKQIVTGIIGAGRIGKLHVQNISRIPHMKIKAISDIQASRIKS WADSHQIEYITSDYRDLLHDPDIDAIFICSPTAVHAQMIKEAAEAKKHIFCEKPVSFS LDETSEALAAVRKHGVTLQVGFNRRFDPHFKKIKTIVENGEIGTPHLLKITSRDPEPP NIDYVRTSGGLFMDMSIHDFDMARYIMGSEVTEVYAKGAALVNPSFAELGDIDTAVIT LTFENGAMAVIDNSRQAVYGYDQRVEVFGTKGSAAADNSRPTTVEVSTADFVMKDKPH FFFLERYKDSYEEEILRFAEAIGTNQETPCTGNDGLQAGRIARAAQQSLAFGMPVSIE HTEKIAF*" gene complement(2659354..2660379) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" promotor_-10 complement(2660416..2660435) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-10" upshifts complement(2660436) /Source="Nicolas_upshifts" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" promotor_-35 complement(2660450..2660457) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-35" promotor_-35 2660505..2660512 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2660526..2660545 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2660534 /Source="Nicolas_upshifts" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" promotor_-35 2660566..2660571 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2660580 /Source="Nicolas_upshifts" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" promotor_-10 2660587..2660605 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2660617..2661264 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" /EC_number="2.7.11.1" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative serine/threonine-protein kinase" /protein_id="NP_390656.2" /db_xref="EnsemblGenomes-Gn:BSU27785" /db_xref="EnsemblGenomes-Tr:CAB14738" /db_xref="GOA:O32057" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13816" /db_xref="UniProtKB/Swiss-Prot:O32057" /translation="MLTKAEALAHTVIYRKNSRFDKVKEKSEELTLIGKGRSAYVFAL TEGGRKMALKVFFPEYQATAVKEAAIYEKLAGSAFYPDIYETGDSFILMEYIKGETFY NCLKKGIAISDDMIQQVEEALSDARAAGLNPSDIHLRNLILTETGAVRVIDVARFEQT KTCTQWDDLKSAYHALYKKPIFPKKIPGFWLEIIAFLYKKDWFQKHFAQRKRKYS*" gene 2660617..2661264 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" S_feature complement(2660939..2661272) /Source="Nicolas_S_feature" /locus_tag="new_2840432_2840765_c" /HighExp="LPhT, S8, BI, S7, S6, C30, Sw, BC, Gly, C90" /AntisenseName="yrzF" /AntisenseCor="0.348831504804749" /AntisenseRegPval="-8.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1051" downshifts 2661243 /Source="Nicolas_upshifts" /id="D1421" /incds=0 /nref=29 /ntot=228 /MaxReadThrough="2.4121" /MaxDrop="5.05737" /score="20.8102477" /energy="-18.2" /TU="NA" /idTUdmin="U2147" /TUdmin="-20" /isTUend="TRUE" S_feature complement(2661274..2661471) /Source="Nicolas_S_feature" /locus_tag="new_2840767_2840964_c" /HighExp="LPhT, BI, B60, S8, Gly, S7, S6, B36, S5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984200000000001" /TUshortSig="Sig-" /TUshortPSig="0.032" /TUlongSig="NA" /TUlongPSig="NA" /label="S1052" CDS complement(2661310..2661432) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513992.1" /db_xref="EnsemblGenomes-Gn:BSU27786" /db_xref="EnsemblGenomes-Tr:CCQ48603" /db_xref="UniProtKB/TrEMBL:L8EAY3" /translation="MEKTYCHSGEKDPEAVYLTVRGYRIKLSPEQMKLISAVRK*" gene complement(2661310..2661432) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" downshifts complement(2661317) /Source="Nicolas_upshifts" /id="D1422" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="4.39913" /MaxDrop="4.52186" /score="39.5790138" /energy="-18.2" /TU="NA" /idTUdmin="U2149" /TUdmin=0 /isTUend="TRUE" upshifts complement(2661480) /Source="Nicolas_upshifts" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" promotor_-10 complement(2661481..2661498) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2661505..2661512) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2661517..2661807 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390658.2" /db_xref="EnsemblGenomes-Gn:BSU27800" /db_xref="EnsemblGenomes-Tr:CAB14740" /db_xref="SubtiList:BG13818" /db_xref="UniProtKB/Swiss-Prot:O32059" /translation="MNPIYSKMREKKGESHIKTENTLSLDAARGELVNEKTLVKRTIY WNYPDSRPAVTWINHNTVKIGNQTLHLDTDETYDWRKDDHWIREEPPQASVR*" gene 2661517..2661807 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" misc_feature 2661528..2661547 /Source="Nicolas_upshift_promotors" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 2661528..2661675 /Source="Nicolas_S_feature" /locus_tag="new_2841021_2841168" /HighExp="T3.30H, T4.0H, T3.0H, T2.0H, T2.30H, T5.0H, M9-stat, S7, T1.30H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99999400000000005" /TUshortSig="SigA" /TUshortPSig="0.903" /TUlongSig="NA" /TUlongPSig="NA" /label="S1053" upshifts 2661528 /Source="Nicolas_upshifts" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" CDS 2661814..2661954 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097769.1" /db_xref="EnsemblGenomes-Gn:BSU27809" /db_xref="EnsemblGenomes-Tr:CAX52675" /db_xref="GOA:C0H464" /db_xref="UniProtKB/Swiss-Prot:C0H464" /translation="MNKMNGTNDEKHFNHFVIALSFIYGLTELGYLLLKDFITIAISL PL*" gene 2661814..2661954 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" downshifts 2661943 /Source="Nicolas_upshifts" /id="D1423" /incds=0 /nref=139 /ntot=241 /MaxReadThrough="0.64189" /MaxDrop="4.74983" /score="23.2933855" /energy="-9.9" /TU="NA" /idTUdmin="U2150" /TUdmin="-2" /isTUend="TRUE" promotor_-35 2662003..2662009 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2662017..2662117 /Source="Nicolas_upshift_promotors" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2662024..2662042 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2662025 /Source="Nicolas_upshifts" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" upshifts 2662077 /Source="Nicolas_upshifts" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" CDS 2662118..2663572 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1400476, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium/proton-dependent alanine transporter" /protein_id="NP_390659.2" /db_xref="EnsemblGenomes-Gn:BSU27810" /db_xref="EnsemblGenomes-Tr:CAB14741" /db_xref="GOA:O32060" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG13784" /db_xref="UniProtKB/Swiss-Prot:O32060" /translation="MADFVASLNAVLWSTPVIYILLGIGFAFSIMTRFLQVRHLKEMI VQMFKGKSSEAGVSSFQALSIALSGRVGTGNIAGVATAIAFGGPGAVFWMWAIAFIGA ASAFVESTLAQIYKVKQDGQYRGGPAYYIEKGLGIKWFAVLFAAAALIAMAFLMPGVQ SNSIAAGIQNAFGISPFVTGCGLVLLLGFIIFGGVKRIANAAQMIVPFMAIGYILLSL IIIVMNVSELPAVISLIFKSAFALDSAFGGLIGMAISWGVKRGIYSNEAGQGTGPHPA AAAEVSHPVKQGLVQAFSVYIDTLFVCSATAFMILFTGMYNTQAADGSFIVHQLKGVE AGPGFTQAAIDSVLPGFGAGFVAIALFFFAFTTIMAYYYIAETNIAYLARGRESKWAM LGLKLIILAATFYGTVKTASLAWALGDAGLGIMVWLNVIAIVLLAKPALLALKDYERQ KKQGLDPIFDPKALGIKNADFWEKEYTHESERVS*" gene 2662118..2663572 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" downshifts 2663573 /Source="Nicolas_upshifts" /id="D1424" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="5.01314" /MaxDrop="4.4617" /score="6.86850608" /energy="-10.8" /TU="U2151" /idTUdmin="U2152" /TUdmin=0 /isTUend="TRUE" CDS complement(2663613..2664335) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12060744, 18641136, 20647113; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor regulating gene expression" /protein_id="NP_390660.1" /db_xref="EnsemblGenomes-Gn:BSU27820" /db_xref="EnsemblGenomes-Tr:CAB14742" /db_xref="GOA:P94447" /db_xref="InterPro:IPR002876" /db_xref="InterPro:IPR017856" /db_xref="InterPro:IPR026564" /db_xref="InterPro:IPR029072" /db_xref="SubtiList:BG13783" /db_xref="UniProtKB/Swiss-Prot:P94447" /translation="MAGHSKWKNIQKRKNAQDAKRGKIFMKLAKEIYVAAKEGGADPE ANSALRLVIEKAKGANMPNENIDRAIKKAAGGQDGSSYEEITYEGYGPSGIAVMVECV TDNKNRTASNVRTAFNKNGGSLGESGCVAFLFERKGFITIDRTERQIEEDELMLDVLE AGGEELRIEEDLYEVFTEPEHFEEVKTALESKYLISSAEVTMLPNTYAEADDQAVEKL ETLIDVLEDDDDVQEVYTNYRS*" gene complement(2663613..2664335) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" S_feature 2663618..2664039 /Source="Nicolas_S_feature" /locus_tag="new_2843111_2843532" /HighExp="S8, S6, S7, BT, C30, S5, S4, LoTm, C90, S3" /AntisenseName="yrbC" /AntisenseCor="-8.4330852334841305E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1054" downshifts complement(2663629) /Source="Nicolas_upshifts" /id="D1425" /incds=0 /nref=11 /ntot=164 /MaxReadThrough="3.2014" /MaxDrop="3.66865" /score="23.9031001" /energy="-16" /TU="U2153" /idTUdmin="U2153" /TUdmin="-574" /isTUend="FALSE" promotor_-10 complement(2664358..2664377) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2664375) /Source="Nicolas_upshifts" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" promotor_-35 complement(2664391..2664398) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2664438..2665034) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9770294, 10438771, 12562816, 17322312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9770294, 10438771, 12562816, 17322312; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_390661.2" /db_xref="EnsemblGenomes-Gn:BSU27830" /db_xref="EnsemblGenomes-Tr:CAB14743" /db_xref="GOA:P94446" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13782" /db_xref="UniProtKB/Swiss-Prot:P94446" /translation="MGKKMTIASLILMTAGLTACGANDNAMNDTRNNGNTRPIGYYTN ENDADRQGDGIDHDGPVSELMEDQNDGNRNTTNVNNRDRVTADDRVPLATDGTYNNTN NRNMNRNAANNGYDNQENRRLAAKIANRVKQVKNVNDTQVMVSDDRVVIAVKSHREFT KSDRDNVVKAARNYANGRDVQVSTDKGLFRKLHKMNNR*" gene complement(2664438..2665034) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" downshifts complement(2664453) /Source="Nicolas_upshifts" /id="D1426" /incds=0 /nref=96 /ntot=172 /MaxReadThrough="2.47709" /MaxDrop="7.18444" /score="23.9031001" /energy="-16" /TU="NA" /idTUdmin="U2154" /TUdmin="-12" /isTUend="TRUE" promotor_-10 complement(2665077..2665088) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2665079) /Source="Nicolas_upshifts" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" S_feature complement(2665081..2665145) /Source="Nicolas_S_feature" /locus_tag="new_2844574_2844638_c" /HighExp="B36, LoTm, S8, S6, S5, BT, B60, S4, S7, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1055" promotor_-35 complement(2665103..2665109) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2665182..2666345) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10438771, 10714986, 10714992, 11040425, 15901704, 26953338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438771, 10714986, 10714992, 11040425, 15901704, 26953338; Product type f : factor" /codon_start=1 /transl_table=11 /product="morphogenetic protein associated with SpoVID" /protein_id="NP_390662.1" /db_xref="EnsemblGenomes-Gn:BSU27840" /db_xref="EnsemblGenomes-Tr:CAB14744" /db_xref="GOA:O32062" /db_xref="InterPro:IPR014248" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13781" /db_xref="UniProtKB/Swiss-Prot:O32062" /translation="MKIHIVQKGDSLWKIAEKYGVDVEEVKKLNTQLSNPDLIMPGMK IKVPSEGVPVRKEPKAGKSPAAGSVKQEHPYAKEKPKSVVDVEDTKPKEKKSMPYVPP MPNLQENVYPEADVNDYYDMKQLFQPWSPPKPEEPKKHHDGNMDHMYHMQDQFPQQEA MSNMENANYPNMPNMPKAPEVGGIEEENVHHTVPNMPMPAVQPYYHYPAHFVPCPVPV SPILPGSGLCYPYYPAQAYPMHPMHGYQPGFVSPQYDPGYENQHHENSHHGHYGSYGA PQYASPAYGSPYGHMPYGPYYGTPQVMGAYQPAAAHGYMPYKDHDDCGCDGDHQPYFS APGHSGMGAYGSPNMPYGTANPNPNPYSAGVSMPMTNQPSVNQMFGRPEEENE*" gene complement(2665182..2666345) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" downshifts complement(2665190) /Source="Nicolas_upshifts" /id="D1427" /incds=0 /nref=34 /ntot=189 /MaxReadThrough="5.61903" /MaxDrop="3.9565" /score="38.1347732" /energy="-11.1" /TU="U2155,U2156,U2159" /idTUdmin="U2154" /TUdmin="-749" /isTUend="FALSE" S_feature complement(2666346..2666421) /Source="Nicolas_S_feature" /locus_tag="new_2845839_2845914_c" /HighExp="S5, S4, B36, LoTm, S3, B60, S7, S6, Pyr, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1056" promotor_-10 complement(2666397..2666415) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2666421) /Source="Nicolas_upshifts" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" promotor_-35 complement(2666431..2666436) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2666462..2667568) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" /EC_number="2.5.1.72" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15898769, 15937336, 15967443, 18959769, 26455817" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15898769, 15937336, 15967443, 18959769, 26455817; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quinolinate synthetase" /protein_id="NP_390663.1" /db_xref="EnsemblGenomes-Gn:BSU27850" /db_xref="EnsemblGenomes-Tr:CAB14745" /db_xref="GOA:Q9KWZ1" /db_xref="InterPro:IPR003473" /db_xref="InterPro:IPR023515" /db_xref="InterPro:IPR036094" /db_xref="SubtiList:BG12629" /db_xref="UniProtKB/Swiss-Prot:Q9KWZ1" /translation="MSILDVIKQSNDMMPESYKELSRKDMETRVAAIKKKFGSRLFIP GHHYQKDEVIQFADQTGDSLQLAQVAEKNKEADYIVFCGVHFMAETADMLTSEQQTVV LPDMRAGCSMADMADMQQTNRAWKKLQHIFGDTIIPLTYVNSTAEIKAFVGKHGGATV TSSNAKKVLEWAFTQKKRILFLPDQHLGRNTAYDLGIALEDMAVWDPMKDELVAESGH TNVKVILWKGHCSVHEKFTTKNIHDMRERDPDIQIIVHPECSHEVVTLSDDNGSTKYI IDTINQAPAGSKWAIGTEMNLVQRIIHEHPDKQIESLNPDMCPCLTMNRIDLPHLLWS LEQIEKGEPSGVIKVPKAIQEDALLALNRMLSIT*" gene complement(2666462..2667568) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" promotor_-10 complement(2667144..2667162) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2667169) /Source="Nicolas_upshifts" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" promotor_-35 complement(2667178..2667183) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2667480 /Source="Nicolas_upshifts" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 2667481..2667484 /Source="Nicolas_upshift_promotors" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2667555..2668424) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" /EC_number="2.4.2.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8419294, 28618168; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide pyrophosphorylase (quinolinate phosphoribosyltransferase)" /protein_id="NP_390664.1" /db_xref="EnsemblGenomes-Gn:BSU27860" /db_xref="EnsemblGenomes-Tr:CAB14746" /db_xref="GOA:P39666" /db_xref="InterPro:IPR002638" /db_xref="InterPro:IPR004393" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022412" /db_xref="InterPro:IPR027277" /db_xref="InterPro:IPR036068" /db_xref="InterPro:IPR037128" /db_xref="SubtiList:BG10868" /db_xref="UniProtKB/Swiss-Prot:P39666" /translation="MNHLQLKKLLNHFFLEDIGTGDLTSQSIFGEQSCEAEIVAKSEG IFAGAAIIKEGFSLLDENVQSILHKKDGDMLHKGEVIAELHGPAAALLSGERVVLNLI QRLSGIATMTREAVRCLDDEQIKICDTRKTTPGLRMLEKYAVRAGGGYNHRFGLYDGI MIKDNHIAACGSILEACKKARQAAGHMVNIEVEIETEEQLREAIAAGADVIMFDNCPP DTVRHFAKLTPANIKTEASGGITLESLPAFKGTGVNYISLGFLTHSVKSLDISMDVTL SNESVEECCYVNS*" gene complement(2667555..2668424) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" downshifts 2667649 /Source="Nicolas_upshifts" /id="D1428" /incds=1 /nref=4 /ntot=107 /MaxReadThrough="0.495279999999999" /MaxDrop="3.83418" /score="-8.75482157" /energy="-7.4" /TU="NA" /idTUdmin="U2157" /TUdmin=6 /isTUend="TRUE" CDS complement(2668378..2669973) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" /EC_number="1.4.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 16199587, 18959769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 16199587, 18959769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-aspartate oxidase" /protein_id="NP_390665.1" /db_xref="EnsemblGenomes-Gn:BSU27870" /db_xref="EnsemblGenomes-Tr:CAB14747" /db_xref="GOA:P38032" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR005288" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10867" /db_xref="UniProtKB/Swiss-Prot:P38032" /translation="MSKKTIAVIGSGAAALSLAAAFPPSYEVTVITKKSVKNSNSVYA QGGIAAAYAKDDSIEAHLEDTLYAGCGHNNLAIVADVLHDGKMMVQSLLERGFPFDRN ERGGVCLGREGAHSYNRIFHAGGDATGRLLIDYLLKRINSKIKLIENETAADLLIEDG RCIGVMTKDSKGRLKVRHADEVVLAAGGCGNLFLHHTNDLTVTGDGLSLAYRAGAELT DLEFTQFHPTLLVKNGVSYGLVSEAVRGEGGCLVDENGRRIMAERHPLGDLAPRDIVS RVIHEEMAKGNRVYIDFSAISDFETRFPTITAICEKAGIDIHSGKIPVAPGMHFLMGG VSVNRWGETTVPGLYAIGETACSGLHGANRLASNSLLEALVFGKRAAEHIIQKPVYNR QYQSGLETSVFYEVPDIEGHELQSKMTSHMSILREQSSLIELSIWLHTLPFQEVNVKD ITIRQMELSHLWQTAKLMTFSALLREESRGAHFRTDFPHAEVSWQGRQIVHTKKGTKI RKNEGIWNNESFTAEKITESLFS*" gene complement(2668378..2669973) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" promotor_-10 complement(2670001..2670020) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2670001..2670008 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2670022 /Source="Nicolas_upshifts" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" promotor_-10 2670024..2670043 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2670025) /Source="Nicolas_upshifts" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" promotor_-35 complement(2670035..2670042) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2670076..2671263 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 14567704, 16199587, 25447671, 26443755, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 14567704, 16199587, 25447671, 26443755, 28882201; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="desulfurase involved in iron-sulfur clusters forNAD biosynthesis" /protein_id="NP_390666.1" /db_xref="EnsemblGenomes-Gn:BSU27880" /db_xref="EnsemblGenomes-Tr:CAB14748" /db_xref="GOA:P38033" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG10866" /db_xref="UniProtKB/Swiss-Prot:P38033" /translation="MIYLDYAATTPICEEALTVYQKLSMDMYGNASSLHDAGGKAKHI LEYCREKIANIIGGEASGIYFTSGGTESNFLAIQSLLNGLPKTKRHFITTAMEHQSIH NCAAFLEQQGYDVTVIEPNEYGLITEEILLTHIRPETGLVSIQHANSETGIIQPIQHL SSYLHNKGILLHCDAVQTFGKIPINTKNLGVDALSMSSHKIHGPKGVGAVYIRPDVPW KPVYPLTTHEYGFRAGTVNVPGIGAFTAAAELIVSEMEKQISRNEALRTYFLDQIRIR SLPVTLAADTSKAECLPHIIGCFFHSFEGQYVMLECNRSNICISTGSACSAGYHGPSE TMKALRKTEQEALQFIRISFGRHTTAEQLEQLLHTFTVLWEQKKGEFDIDRRIKANGR QQA*" gene 2670076..2671263 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" promotor_-10 complement(2670077..2670096) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2670095) /Source="Nicolas_upshifts" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2670111..2670120) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2670978..2670983 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2670992 /Source="Nicolas_upshifts" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" promotor_-10 2670994..2671013 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2671223..2671765 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16199587, 18276644" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16199587, 18276644; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of de novo NAD biosynthesis" /protein_id="NP_390667.2" /db_xref="EnsemblGenomes-Gn:BSU27890" /db_xref="EnsemblGenomes-Tr:CAB14749" /db_xref="GOA:P39667" /db_xref="InterPro:IPR004173" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026043" /db_xref="InterPro:IPR035922" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10865" /db_xref="UniProtKB/Swiss-Prot:P39667" /translation="MTEELKLMGANRRDQLLLWLKESKSPLTGGELAKKANVSRQVIV QDISLLKAKNVPIIATSQGYVYMDAAAQQHQQAERIIACLHGPERTEEELQLIVDEGV TVKDVKIEHPVYGDLTAAIQVGTRKEVSHFIKKINSTNAAYLSQLTDGVHLHTLTAPD EHRIDQACQALEEAGILIKD*" gene 2671223..2671765 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" downshifts 2671748 /Source="Nicolas_upshifts" /id="D1429" /incds=0 /nref=109 /ntot=246 /MaxReadThrough="3.55509" /MaxDrop="5.04771" /score="15.054047" /energy="-5.6" /TU="U2158" /idTUdmin="U2161" /TUdmin="-8" /isTUend="TRUE" CDS complement(2671790..2672647) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" /EC_number="4.2.1.51" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:104661, 114523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104661, 114523; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydratase" /protein_id="NP_390668.1" /db_xref="EnsemblGenomes-Gn:BSU27900" /db_xref="EnsemblGenomes-Tr:CAB14750" /db_xref="GOA:P21203" /db_xref="InterPro:IPR001086" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008242" /db_xref="InterPro:IPR018528" /db_xref="SubtiList:BG10914" /db_xref="UniProtKB/Swiss-Prot:P21203" /translation="MKVGYLGPAATFTHLAVSSCFQNGAEHVAYRTIPECIDAAVAGE VDFAFVPLENALEGSVNLTIDYLIHEQPLPIVGEMTLPIHQHLLVHPSRENAWKELDK IYSHSHAIAQCHKFLHRHFPSVPYEYANSTGAAAKFVSDHPELNIGVIANDMAASTYE LKIVKRDIQDYRDNHTRFVILSPDENISFEVNSKLSSRPKTTLMVMLPQDDQSGALHR VLSAFSWRNLNLSKIESRPTKTGLGHYFFIIDIEKAFDDVLIPGAMQELEALGCKVRL LGAYQSYQL*" gene complement(2671790..2672647) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" S_feature 2671793..2672502 /Source="Nicolas_S_feature" /locus_tag="new_2851286_2851995" /HighExp="S2, T-5.40H, T3.30H, T-4.40H, GM-0.2, GM-0.1, Pyr, T4.0H, T5.0H, GM 10" /AntisenseName="pheA" /AntisenseCor="-0.15664933741609299" /AntisenseRegPval="-2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1057" downshifts complement(2671810) /Source="Nicolas_upshifts" /id="D1430" /incds=0 /nref=173 /ntot=247 /MaxReadThrough="1.87872" /MaxDrop="5.15605" /score="13.965695" /energy="-5.6" /TU="NA" /idTUdmin="U2162" /TUdmin=0 /isTUend="TRUE" CDS complement(2672664..2673107) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" /experiment="publication(s) with functional evidences, PMID:2537815, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2537815, 27260660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of operons hom-thrCB and thrD" /protein_id="NP_390669.1" /db_xref="EnsemblGenomes-Gn:BSU27910" /db_xref="EnsemblGenomes-Tr:CAB14751" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008310" /db_xref="SubtiList:BG10913" /db_xref="UniProtKB/Swiss-Prot:P21204" /translation="MKEETFYLVREDVLPDAMRKTLEVKKLLDRKKADSVADAVQKVD LSRSAFYKYRDAVFPFYTMVKEQIITLFFHLEDRSGALSQLLQAVADSGSNVLSIHQT IPLQGRANVTLSISTSAMEEDIHTLMNKLRKFDFVEKVEILGSGA*" gene complement(2672664..2673107) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" CDS complement(2673168..2674454) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ppGpp-binding GTPase involved in cell portioning, DNA repair and ribosome assembly" /protein_id="NP_390670.1" /db_xref="EnsemblGenomes-Gn:BSU27920" /db_xref="EnsemblGenomes-Tr:CAB14752" /db_xref="GOA:P20964" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR006074" /db_xref="InterPro:IPR006169" /db_xref="InterPro:IPR014100" /db_xref="InterPro:IPR015349" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="InterPro:IPR035101" /db_xref="InterPro:IPR036346" /db_xref="InterPro:IPR036726" /db_xref="PDB:1LNZ" /db_xref="SubtiList:BG10337" /db_xref="UniProtKB/Swiss-Prot:P20964" /translation="MFVDQVKVYVKGGDGGNGMVAFRREKYVPKGGPAGGDGGKGGDV VFEVDEGLRTLMDFRYKKHFKAIRGEHGMSKNQHGRNADDMVIKVPPGTVVTDDDTKQ VIADLTEHGQRAVIARGGRGGRGNSRFATPANPAPQLSENGEPGKERYIVLELKVLAD VGLVGFPSVGKSTLLSVVSSAKPKIADYHFTTLVPNLGMVETDDGRSFVMADLPGLIE GAHQGVGLGHQFLRHIERTRVIVHVIDMSGLEGRDPYDDYLTINQELSEYNLRLTERP QIIVANKMDMPEAAENLEAFKEKLTDDYPVFPISAVTREGLRELLFEVANQLENTPEF PLYDEEELTQNRVMYTMENEEVPFNITRDPDGVFVLSGDSLERLFKMTDFSRDESVKR FARQMRGMGVDEALRERGAKDGDIIRLLEFEFEFID*" gene complement(2673168..2674454) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" CDS complement(2674488..2675066) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation initiation phosphotransferase" /protein_id="NP_390671.1" /db_xref="EnsemblGenomes-Gn:BSU27930" /db_xref="EnsemblGenomes-Tr:CAB14753" /db_xref="GOA:P06535" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR016122" /db_xref="InterPro:IPR037100" /db_xref="PDB:1F51" /db_xref="PDB:1IXM" /db_xref="PDB:2FTK" /db_xref="SubtiList:BG10336" /db_xref="UniProtKB/Swiss-Prot:P06535" /translation="MKDVSKNQEENISDTALTNELIHLLGHSRHDWMNKLQLIKGNLS LQKYDRVFEMIEEMVIDAKHESKLSNLKTPHLAFDFLTFNWKTHYMTLEYEVLGEIKD LSAYDQKLAKLMRKLFHLFDQAVSRESENHLTVSLQTDHPDRQLILYLDFHGAFADPS AFDDIRQNGYEDVDIMRFEITSHECLIEIGLD*" gene complement(2674488..2675066) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" S_feature complement(2675067..2675132) /Source="Nicolas_S_feature" /locus_tag="new_2854560_2854625_c" /HighExp="Cold, H2O2, G135, Paraq, G180, Oxctl, G150, C30, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigEF" /TUlongPSig=1 /label="S1058" promotor_-10 complement(2675117..2675136) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2675132) /Source="Nicolas_upshifts" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" S_feature complement(2675134..2675351) /Source="Nicolas_S_feature" /locus_tag="new_2854627_2854844_c" /HighExp="Cold, G135, H2O2, Paraq, G180, Oxctl, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1059" CDS 2675144..2675266 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513993.1" /translation="MLEKQLFFPEISCSFFLALVDLQPGRTFYVLLLGEHIQWV*" gene 2675144..2675266 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" promotor_-35 complement(2675150..2675157) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2675387..2675671) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 (BL24)" /protein_id="NP_390672.1" /db_xref="EnsemblGenomes-Gn:BSU27940" /db_xref="EnsemblGenomes-Tr:CAB14754" /db_xref="GOA:P05657" /db_xref="InterPro:IPR001684" /db_xref="InterPro:IPR018261" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10335" /db_xref="UniProtKB/Swiss-Prot:P05657" /translation="MLRLDLQFFASKKGVGSTKNGRDSEAKRLGAKRADGQFVTGGSI LYRQRGTKIYPGENVGRGGDDTLFAKIDGTVKFERFGRDRKKVSVYPVAQ*" gene complement(2675387..2675671) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" downshifts complement(2675396) /Source="Nicolas_upshifts" /id="D1431" /incds=0 /nref=212 /ntot=261 /MaxReadThrough="7.39131" /MaxDrop="7.26483" /score="32.4992871" /energy="-12.5" /TU="U2163" /idTUdmin="U2164" /TUdmin=1078 /isTUend="FALSE" CDS complement(2675684..2676022) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11567142, 22333191, 25388641, 27435445, 28187498; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 specific N-terminal end cysteine protease" /protein_id="NP_390673.2" /db_xref="EnsemblGenomes-Gn:BSU27950" /db_xref="EnsemblGenomes-Tr:CAB14755" /db_xref="InterPro:IPR007422" /db_xref="InterPro:IPR036764" /db_xref="SubtiList:BG10334" /db_xref="UniProtKB/Swiss-Prot:P26942" /translation="MIQATIRRSHDKGILSFEMTGHANFAEHGQDLVCAGVTAVVFGA VNAVIVLAGFEPLLDIGEDGGYFYFEFPESLDPEARQKAQLLIEGMIVSLETIERDYK DNLRVTTNII*" gene complement(2675684..2676022) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" CDS complement(2676025..2676333) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8223574, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8223574, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L21 (BL20)" /protein_id="NP_390674.1" /db_xref="EnsemblGenomes-Gn:BSU27960" /db_xref="EnsemblGenomes-Tr:CAB14756" /db_xref="GOA:P26908" /db_xref="InterPro:IPR001787" /db_xref="InterPro:IPR018258" /db_xref="InterPro:IPR028909" /db_xref="InterPro:IPR036164" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10333" /db_xref="UniProtKB/Swiss-Prot:P26908" /translation="MYAIIKTGGKQIKVEEGQTVYIEKLAAEAGETVTFEDVLFVGGD NVKVGNPTVEGATVTAKVEKQGRAKKITVFRYKPKKNVHKKQGHRQPYTKVTIEKINA *" gene complement(2676025..2676333) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" misc_RNA complement(2676347..2676422) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" /product="ribosomal protein L21 leader mRNA sequence" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27381917" gene complement(2676347..2676422) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" promotor_-10 complement(2676434..2676453) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2676454) /Source="Nicolas_upshifts" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" promotor_-35 complement(2676467..2676474) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2676480..2677346) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" /EC_number="3.4.24.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease [proteolysis of pro-sigma(K)]" /protein_id="NP_390675.1" /db_xref="EnsemblGenomes-Gn:BSU27970" /db_xref="EnsemblGenomes-Tr:CAB14757" /db_xref="GOA:P26937" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG10332" /db_xref="UniProtKB/Swiss-Prot:P26937" /translation="MNKWLDLILKIHVHPFLWIIAALGLLTGHMKALLCLLLIVLIHE LGHAALAVFFSWRIKRVFLLPFGGTVEVEEHGNRPLKEEFAVIIAGPLQHIWLQFAAW MLAEVSVIHQHTFELFTFYNLSILFVNLLPIWPLDGGKLLFLLFSKQLPFQKAHRLNL KTSLCFCLLLGCWVLFVIPLQISAWVLFVFLAVSLFEEYRQRHYIHVRFLLERYYGKN RELEKLLPLTVKAEDKVYHVMAEFKRGCKHPIIIEKSGQKLSQLDENEVLHAYFADKR TNSSMEELLLPY*" gene complement(2676480..2677346) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" CDS complement(2677339..2678133) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpoIVFB (stage IV sporulation)" /protein_id="NP_390676.1" /db_xref="EnsemblGenomes-Gn:BSU27980" /db_xref="EnsemblGenomes-Tr:CAB14758" /db_xref="GOA:P26936" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG10331" /db_xref="UniProtKB/Swiss-Prot:P26936" /translation="MSHRADEIRKRLEKRRKQLSGSKRFSTQTVSEKQKPPSWVMVTD QEKHGTLPVYEDNMPTFNGKHPLVKTDSIILKCLLSACLVLVSAIAYKTNIGPVSQIK PAVAKTFETEFQFASASHWFETKFGNPLAFLAPEHKNKEQQIEVGKDLIAPASGKVQQ DFQDNGEGIKVETSSDKIDSVKEGYVVEVSKDSQTGLTVKVQHADNTYSIYGELKDVD VALYDFVDKGKKLGSIKLDDHNKGVYYFAMKDGDKFIDPIQVISFE*" gene complement(2677339..2678133) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" downshifts 2678136 /Source="Nicolas_upshifts" /id="D1432" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="1.00279" /MaxDrop="2.6024" /score="-6.66807377" /energy="-6.9" /TU="NA" /idTUdmin="U2165" /TUdmin="-131" /isTUend="FALSE" promotor_no_box 2678142..2678242 /Source="Nicolas_upshift_promotors" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(2678157..2678175) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-10" upshifts complement(2678168) /Source="Nicolas_upshifts" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" promotor_-35 complement(2678191..2678196) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-35" upshifts 2678202 /Source="Nicolas_upshifts" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2678245 /Source="Nicolas_upshifts" /id="D1433" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="1.68429" /MaxDrop="7.01891" /score="-6.66807377" /energy="-6.9" /TU="U2165" /idTUdmin="U2165" /TUdmin="-22" /isTUend="TRUE" downshifts complement(2678280) /Source="Nicolas_upshifts" /id="D1434" /incds=0 /nref=236 /ntot=262 /MaxReadThrough="2.68001" /MaxDrop="5.80551" /score="40.3102023" /energy="-12.6" /TU="U2166" /idTUdmin="U2167" /TUdmin="-3" /isTUend="TRUE" CDS complement(2678283..2679089) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATPase activator of MinC" /protein_id="NP_390677.1" /db_xref="EnsemblGenomes-Gn:BSU27990" /db_xref="EnsemblGenomes-Tr:CAB14759" /db_xref="GOA:Q01464" /db_xref="InterPro:IPR002586" /db_xref="InterPro:IPR010223" /db_xref="InterPro:IPR025501" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10330" /db_xref="UniProtKB/Swiss-Prot:Q01464" /translation="MGEAIVITSGKGGVGKTTTSANLGTALAILGKRVCLVDTDIGLR NLDVVMGLENRIIYDLVDVVEGRCKMHQALVKDKRFDDLLYLMPAAQTSDKTAVAPEQ IKNMVQELKQEFDYVIIDCPAGIEQGYKNAVSGADKAIVVTTPEISAVRDADRIIGLL EQEENIEPPRLVVNRIRNHLMKNGDTMDIDEIVQHLSIDLLGIVADDDEVIKASNHGE PIAMDPKNRASIAYRNIARRILGESVPLQVLEEQNKGMMAKIKSFFGVRS*" gene complement(2678283..2679089) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" CDS complement(2679091..2679771) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division regulator (septum placement)" /protein_id="NP_390678.1" /db_xref="EnsemblGenomes-Gn:BSU28000" /db_xref="EnsemblGenomes-Tr:CAB14760" /db_xref="GOA:Q01463" /db_xref="InterPro:IPR005526" /db_xref="InterPro:IPR013033" /db_xref="InterPro:IPR036145" /db_xref="PDB:2M4I" /db_xref="SubtiList:BG10329" /db_xref="UniProtKB/Swiss-Prot:Q01463" /translation="MKTKKQQYVTIKGTKNGLTLHLDDACSFDELLDGLQNMLSIEQY TDGKGQKISVHVKLGNRFLYKEQEEQLTELIASKKDLFVHSIDSEVITKKEAQQIREE AEIISVSKIVRSGQVLQVKGDLLLIGDVNPGGTVRAGGNIFVLGSLKGIAHAGFNGNN QAVIAASEMLPTQLRINHVLNRSPDHIQKGNEMECAYLDTDGNMVIERLQHLAHLRPD LTRLEGGM*" gene complement(2679091..2679771) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" CDS complement(2679824..2680342) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 18156271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 18156271; Product type s: structure" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390679.1" /db_xref="EnsemblGenomes-Gn:BSU28010" /db_xref="EnsemblGenomes-Tr:CAB14761" /db_xref="GOA:Q01467" /db_xref="InterPro:IPR007227" /db_xref="SubtiList:BG10328" /db_xref="UniProtKB/Swiss-Prot:Q01467" /translation="MKRFLLPFVMMLVFSAESIFTDLVHFPFVTDDQVLAPRFLMLVL IFMSAFINQKHAMIYGFIFGFLYDMNYTSLLGVYMFGFAGLCYLASKAFKVLHTNAFV VILIAVLAVCLLEFYVFGIQSLIHKDIMTFNGFVLDRFIPTILLNIAAALILVLPFRL FFMSLKKELRDE*" gene complement(2679824..2680342) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" CDS complement(2680339..2681211) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 17427287, 20623345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 17427287, 20623345; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390680.2" /db_xref="EnsemblGenomes-Gn:BSU28020" /db_xref="EnsemblGenomes-Tr:CAB14762" /db_xref="GOA:Q01466" /db_xref="InterPro:IPR007221" /db_xref="SubtiList:BG10327" /db_xref="UniProtKB/Swiss-Prot:Q01466" /translation="MPNKRLMLLLLCIIILVAMIGFSLKGGRNTTWPEKVIGDTTGVF QNIFHTPAEFFAGIFENINDLKNTYKENERLREKLDGQTQYEAKLQELEEENKSLRDE LGHVKSIKDYKPILATVIARSPDNWAKQVTINKGTQQNVAKDMAVTNEKGALIGKIKS SGLNNFTSAVQLLSDTDRNNRVATKISGKKGSKGYGLIEGYDKEKKRLKMTIIERKDK QDVKKGDLIETSGTGGVFPEGLTIGEVTDIESDSYGLTKVAYVKPAADLTDLNNVIVV NRDVPTVDTEEEGS*" gene complement(2680339..2681211) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" CDS complement(2681242..2682255) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390681.2" /db_xref="EnsemblGenomes-Gn:BSU28030" /db_xref="EnsemblGenomes-Tr:CAB14763" /db_xref="GOA:Q01465" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10326" /db_xref="UniProtKB/Swiss-Prot:Q01465" /translation="MFGIGARDLGIDLGTANTLVFVKGKGIVVREPSVVALQTDTKSI VAVGNDAKNMIGRTPGNVVALRPMKDGVIADYETTATMMKYYINQAIKNKGMFARKPY VMVCVPSGITAVEERAVIDATRQAGARDAYPIEEPFAAAIGANLPVWEPTGSMVVDIG GGTTEVAIISLGGIVTSQSIRVAGDEMDDAIINYIRKTYNLMIGDRTAEAIKMEIGSA EAPEESDNMEIRGRDLLTGLPKTIEITGKEISNALRDTVSTIVEAVKSTLEKTPPELA ADIMDRGIVLTGGGALLRNLDKVISEETKMPVLIAEDPLDCVAIGTGKALEHIHLFKG KTR*" gene complement(2681242..2682255) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" upshifts complement(2682296) /Source="Nicolas_upshifts" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" misc_feature complement(2682308..2682326) /Source="Nicolas_upshift_promotors" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2682347..2683042) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10652786, 17434969, 18556794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved nucleotide-related metabolism protein" /protein_id="NP_390682.1" /db_xref="EnsemblGenomes-Gn:BSU28040" /db_xref="EnsemblGenomes-Tr:CAB14764" /db_xref="GOA:Q02170" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR001405" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR020891" /db_xref="InterPro:IPR025657" /db_xref="SubtiList:BG10325" /db_xref="UniProtKB/Swiss-Prot:Q02170" /translation="MVIHDLPLKLKDFPMKEKPRERLLKVGAENLANHELLAILLRTG TKHESVLDLSNRLLRSFDGLRLLKEASVEELSSIPGIGMVKAIQILAAVELGSRIHKL ANEEHFVIRSPEDGANLVMEDMRFLTQEHFVCLYLNTKNQVIHKRTVFIGSLNSSIVH PREVFKEAFKRSAASFICVHNHPSGDPTPSREDIEVTRRLFECGNLIGIELLDHLVIG DKKFVSLKEKGYL*" gene complement(2682347..2683042) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" CDS complement(2683079..2683648) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" /EC_number="3.6.1.9" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10841541, 16216582, 21564336, 24210219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10841541, 16216582, 21564336, 24210219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside triphosphate pyrophosphatase; septum formation DNA-binding protein (multicopy associated filamentation)" /protein_id="NP_390683.1" /db_xref="EnsemblGenomes-Gn:BSU28050" /db_xref="EnsemblGenomes-Tr:CAB14765" /db_xref="GOA:Q02169" /db_xref="InterPro:IPR003697" /db_xref="InterPro:IPR029001" /db_xref="PDB:1EX2" /db_xref="PDB:1EXC" /db_xref="PDB:4HEB" /db_xref="SubtiList:BG10324" /db_xref="UniProtKB/Swiss-Prot:Q02169" /translation="MTKPLILASQSPRRKELLDLLQLPYSIIVSEVEEKLNRNFSPEE NVQWLAKQKAKAVADLHPHAIVIGADTMVCLDGECLGKPQDQEEAASMLRRLSGRSHS VITAVSIQAENHSETFYDKTEVAFWSLSEEEIWTYIETKEPMDKAGAYGIQGRGALFV KKIDGDYYSVMGLPISKTMRALRHFDIRA*" gene complement(2683079..2683648) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" promotor_-10 complement(2683500..2683515) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2683509) /Source="Nicolas_upshifts" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" promotor_-35 complement(2683528..2683537) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2683687..2683706) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2683703) /Source="Nicolas_upshifts" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" promotor_-35 complement(2683720..2683726) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2683799) /Source="Nicolas_upshifts" /id="D1435" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="1.92542" /MaxDrop="5.77117" /score="8.94061802" /energy="-7.4" /TU="NA" /idTUdmin="U2169" /TUdmin=1 /isTUend="TRUE" CDS complement(2683801..2684799) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16959571, 17376078, 22720735, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16959571, 17376078, 22720735, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spatial and temporal regulator of the dissolution of septal peptidoglycan during engulfment (stage II sporulation)" /protein_id="NP_390684.1" /db_xref="EnsemblGenomes-Gn:BSU28060" /db_xref="EnsemblGenomes-Tr:CAB14766" /db_xref="GOA:P37575" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="SubtiList:BG10912" /db_xref="UniProtKB/Swiss-Prot:P37575" /translation="MKKRKNKKNSKAAEKALKVTINGKEETVYEQETPETEANKSMTF SNWEEKRQAEQEVAASQEHPDEDEFNWDSEEDKVFKEDPKVVPPFQKKKTKLYAKGKT GAAKPVKRVAATIAFAAVIGTGLGLFALNISGNKEASAPASLEDSLGSQTAKAGDTSA DKQTSGAEKQAAQTEGTYKTYAVQAGKFSNEKGAETLTEQLTEKGYSAVSLSKDDGYT YVIAGLASEKEVSQQLGQVLIDSDFEAWGGKELSLSIESDMTDSFKETAELAAKAILD EDITKASVEKIEKSLGETKASETGEKKAILQALKELEDPSAEAGWKAQQELLAVVK*" gene complement(2683801..2684799) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" promotor_-10 complement(2684846..2684865) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2684854) /Source="Nicolas_upshifts" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" promotor_-35 complement(2684877..2684884) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2684922) /Source="Nicolas_upshifts" /id="D1436" /incds=0 /nref=1 /ntot=56 /MaxReadThrough="3.18314" /MaxDrop="2.89774" /score="11.209969" /energy="-7.6" /TU="U2170" /idTUdmin="U2170" /TUdmin="-440" /isTUend="FALSE" CDS complement(2684933..2685679) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" /EC_number="3.4.23.43" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2553669, 9723928, 15849754, 16751195, 16850406, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2553669, 9723928, 15849754, 16751195, 16850406, 16751195; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane prepilin peptidase" /protein_id="NP_390685.2" /db_xref="EnsemblGenomes-Gn:BSU28070" /db_xref="EnsemblGenomes-Tr:CAB14767" /db_xref="GOA:P15378" /db_xref="InterPro:IPR000045" /db_xref="InterPro:IPR010627" /db_xref="SubtiList:BG10323" /db_xref="UniProtKB/Swiss-Prot:P15378" /translation="MLSILFIFGLILGSFYYTAGCRIPLHLSIIAPRSSCPFCRRTLT PAELIPILSFLFQKGKCKSCGHRISFMYPAAELVTACLFAAAGIRFGISLELFPAVVF ISLLIIVAVTDIHFMLIPNRILIFFLPFLAAARLISPLDSWYAGLLGAAAGFLFLAVI AAITHGGVGGGDIKLFAVIGFVLGVKMLAAAFFFSVLIGALYGAAAVLTGRLAKRQPL PFAPAIAAGSILAYLYGDSIISFYIKMALG*" gene complement(2684933..2685679) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" promotor_-10 complement(2685707..2685726) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2685714) /Source="Nicolas_upshifts" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" promotor_-35 complement(2685741..2685748) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2685819..2687111) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" /EC_number="6.3.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2105929, 2985605, 3040739, 6994831, 9098041, 15705579, 22720735, 26443588; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="folyl-polyglutamate synthase" /protein_id="NP_390686.1" /db_xref="EnsemblGenomes-Gn:BSU28080" /db_xref="EnsemblGenomes-Tr:CAB14768" /db_xref="GOA:Q05865" /db_xref="InterPro:IPR001645" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR018109" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10322" /db_xref="UniProtKB/Swiss-Prot:Q05865" /translation="MFTAYQDARSWIHGRLKFGVKPGLGRMKQLMARLGHPEKKIRAF HVAGTNGKGSTVAFIRSMLQEAGYTVGTFTSPYIITFNERISVNGIPISDEEWTALVN QMKPHVEALDQTEYGQPTEFEIMTACAFLYFAEFHKVDFVIFETGLGGRFDSTNVVEP LLTVITSIGHDHMNILGNTIEEIAGEKAGIIKEGIPIVTAVTQPEALQVIRHEAERHA APFQSLHDACVIFNEEALPAGEQFSFKTEEKCYEDIRTSLIGTHQRQNAALSILAAEW LNKENIAHISDEALRSGLVKAAWPGRLELVQEHPPVYLDGAHNEEGVEKLAETMKQRF ANSRISVVFSALKDKPYQNMIKRLETIAHAIHFASFDFPRASLAKDLYDASEISNKSW SEDPDDVIKFIESKKGSNEIVLITGSLYFISDIRKRLK*" gene complement(2685819..2687111) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" downshifts complement(2685824) /Source="Nicolas_upshifts" /id="D1437" /incds=0 /nref=1 /ntot=121 /MaxReadThrough="1.66565" /MaxDrop="3.18428" /score="24.7086033" /energy="-14.3" /TU="NA" /idTUdmin="U2171" /TUdmin=0 /isTUend="TRUE" S_feature complement(2687112..2687170) /Source="Nicolas_S_feature" /locus_tag="new_2866605_2866663_c" /HighExp="S0, LBGexp, G150, MG 45, G135, G180, Gly, Oxctl, M0t45, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1060" CDS complement(2687171..2689813) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" /EC_number="6.1.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9098041, 11114335, 25310979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 11114335, 25310979; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="valyl-tRNA synthetase" /protein_id="NP_390687.2" /db_xref="EnsemblGenomes-Gn:BSU28090" /db_xref="EnsemblGenomes-Tr:CAB14769" /db_xref="GOA:Q05873" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002303" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR019499" /db_xref="InterPro:IPR033705" /db_xref="InterPro:IPR037118" /db_xref="SubtiList:BG10321" /db_xref="UniProtKB/Swiss-Prot:Q05873" /translation="METNEQTMPTKYDPAAVEKDRYDFWLKGKFFEAGSDQTKEPYSV VIPPPNVTGRLHLGHAWDTTLQDIVTRMKRMQGYDVLWLPGMDHAGIATQAKVEAKLR EEGKSRYDLGREKFLEETWKWKEEYADFIRSQWAKLGLGLDYSRERFTLDEGLSKAVR EVFVKLYEKGLIYRGEYIINWDPATKTALSDIEVIYKDVQGAFYHMSYPLADGSGSIE IATTRPETMLGDTAVAVHPEDERYKHLIGKTVILPIVNREIPIVGDDYVDMEFGSGAV KITPAHDPNDFELGNRHNLERILVMNEDGTMNENALQYQGMDRFECRKKLVKDLQEAG VLFKIEDHMHSVGHSERSGAVVEPYLSTQWFVRMQPLADAAIELQKKEEKVNFVPDRF EKTYLHWMENIRDWCISRQLWWGHRIPAWYHKETGELYVGLEAPEDSENWEQDTDVLD TWFSSALWPFSTMGWPDVTAEDFKRYYPTDVLVTGYDIIFFWVSRMIFQGIEFTGERP FKDVLIHGLIRDEQGRKMSKSLGNGVDPMDVIDKYGADSLRYFLATGSSPGQDLRFSY EKVESTWNFANKIWNASRFALMNMDGMTYDELDLSGEKSVADKWILTRLNETIEHVTQ LADRYEFGEVGRHLYNFIWDDFCDWYIEMAKLPLYGEDEAAKKTTRSILAYVLDQTMR LLHPFMPFLTEEIWQHLPHQGESITVSQWPAVVPEHTDTEAAADMKLLVELIRSVRNI RSEVNTPMSKQVELYIKTSTDEIASRLEANRSYVERFTNPSVLKIGTDIEAVDKAMTA VVSGAEVILPLEGLINIDEEIARLQKEFDKLTKEVERVQKKLGNEGFMKKAPAHVIDE EREKEKDYVAKRDAVQKRMAELKG*" gene complement(2687171..2689813) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" S_feature complement(2689814..2689872) /Source="Nicolas_S_feature" /locus_tag="new_2869307_2869365_c" /HighExp="G150, G180, LBGexp, Oxctl, G135, dia0, HPh, Lbexp, Paraq, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigEF" /TUshortPSig="1, 0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1061" misc_RNA complement(2689873..2690095) /gene="tboV" /locus_tag="BSU_misc_RNA_44" /product="T-box riboswitch specific of valine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" gene complement(2689873..2690095) /gene="tboV" /locus_tag="BSU_misc_RNA_44" downshifts complement(2689916) /Source="Nicolas_upshifts" /id="D1438" /incds=0 /nref=9 /ntot=27 /MaxReadThrough="6.76593" /MaxDrop="4.53149" /score="23.9897385" /energy="-20" /TU="U2171,U2173,U2176" /idTUdmin="U2176" /TUdmin="-726" /isTUend="FALSE" promotor_-10 complement(2690124..2690143) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2690136) /Source="Nicolas_upshifts" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" S_feature complement(2690138..2690246) /Source="Nicolas_S_feature" /locus_tag="new_2869631_2869739_c" /HighExp="S8, S6, S7, S5, B36, LoTm, S4, S3, BT, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigEF" /TUshortPSig="0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1062" promotor_-35 complement(2690158..2690163) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2690200..2690209 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2690222..2690241 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2690223 /Source="Nicolas_upshifts" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" promotor_-10 complement(2690239..2690253) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2690246) /Source="Nicolas_upshifts" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" promotor_-35 complement(2690261..2690265) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2690261..2690452 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097770.1" /db_xref="EnsemblGenomes-Gn:BSU28099" /db_xref="EnsemblGenomes-Tr:CAX52676" /db_xref="GOA:C0H465" /db_xref="UniProtKB/Swiss-Prot:C0H465" /translation="MKKRFSSYSLPPWVRQIRLVSAQVIIPITIFQGIRTIFFPTTFD VLLLAILIFLACALHLEWI*" gene 2690261..2690452 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" CDS complement(2690471..2691496) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16371471, 16390444, 22091839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16371471, 16390444, 22091839; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390688.1" /db_xref="EnsemblGenomes-Gn:BSU28100" /db_xref="EnsemblGenomes-Tr:CAB14770" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014253" /db_xref="SubtiList:BG10347" /db_xref="UniProtKB/Swiss-Prot:P37964" /translation="MEDTQSVLQEYGLTAQFIEPVSPLVWKVYTDYGIFALKKLKEGR GKHFTDHMVAIEEKGFRSFVPVYRTNSGEFFSAGIQYGDIYYLMPWLQFDQEEERDQK HAYLFRETARLHERTAQELKVRRDEIERYYGQTKKKWEQDKIFYEQFVDRAEKEWYLS PFELQAITYFSETISAVNFALERLEDWYESAKEKDVSRVVMNHGSLSIHHFLYNDAGT GYFTNFERASVGPPQNDLLGFYTKMFRGFPKACPECVEWFYGYTKSFPLREAEVSLFL SYMAYPAAMYKVLNGYQTGKRQHEKEECTQLLKAYWQMKNIEPFVMKIHQIEQEKKFQ AENESTS*" gene complement(2690471..2691496) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" downshifts complement(2690501) /Source="Nicolas_upshifts" /id="D1439" /incds=0 /nref=23 /ntot=70 /MaxReadThrough="4.44965" /MaxDrop="6.68961" /score="-7.46388093" /energy="-12.1" /TU="U2176" /idTUdmin="U2176" /TUdmin="-1311" /isTUend="FALSE" CDS complement(2691529..2693256) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11325931, 16371471, 16950916, 22773792, 23178679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325931, 16371471, 16950916, 22773792, 23178679; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenetic spore protein (stage VI sporulation)" /protein_id="NP_390689.1" /db_xref="EnsemblGenomes-Gn:BSU28110" /db_xref="EnsemblGenomes-Tr:CAB14771" /db_xref="GOA:P37963" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10346" /db_xref="UniProtKB/Swiss-Prot:P37963" /translation="MPQNHRLQFSVEESICFQKGQEVSELLSISLDPDIRVQEVNDYV SIIGSLELTGEYNIDQNKHTEEIYTDKRFVEQVRKREDGSAELTHCFPVDITIPKNKV SHLQDVFVFIDAFDYQLTDSRILTIQADLAIEGLLDDTQDKEPEIPLYEAPAAFREEE LSEPPAHSVVEEPGASSAEEAVLQHEPPAEPPELFISKAGLREELETEKAESEPPESV ASEPEAREDVKEEEESEELAVPETEVRAESETEESEPEPDPSEIEIQEIVKAKKETAE PAAAIADVREEADSPAETELREHVGAEESPALEAELHSETVIAKEKEETTVSPNHEYA LRQEAQNEEAAQSDQADPALCQEEAEPDEALESVSEAALSIEDSRETASAVYMENDNA DLHFHFNQKTSSEEASQEELPEPAYRTFLPEQEEEDSFYSAPKLLEEEEQEEESFEIE VRKTPSAEEPKEETPFQSFQLPESSETERKETDAVPRVAPAAETKEPQTKESDNSLYL TKLFTKEADEFSRMKICIVQQEDTIERLCERYEITSQQLIRMNSLALDDELKAGQILY IPQYKNSHA*" gene complement(2691529..2693256) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" promotor_-35 2692858..2692861 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2692877..2692896 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2692883 /Source="Nicolas_upshifts" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 2693252..2693256 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2693265..2693279 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2693279 /Source="Nicolas_upshifts" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2693294..2693312) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-10" upshifts complement(2693310) /Source="Nicolas_upshifts" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" promotor_-35 complement(2693328..2693333) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-35" CDS complement(2693387..2694679) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 12029044, 15802251, 16682782, 20946885, 27303897" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 12029044, 15802251, 16682782, 20946885, 27303897; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde 2,1-aminomutase" /protein_id="NP_390690.1" /db_xref="EnsemblGenomes-Gn:BSU28120" /db_xref="EnsemblGenomes-Tr:CAB14772" /db_xref="GOA:P30949" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3BS8" /db_xref="SubtiList:BG10345" /db_xref="UniProtKB/Swiss-Prot:P30949" /translation="MRSYEKSKTAFKEAQKLMPGGVNSPVRAFKSVDMDPIFMERGKG SKIFDIDGNEYIDYVLSWGPLILGHTNDRVVESLKKVAEYGTSFGAPTEVENELAKLV IDRVPSVEIVRMVSSGTEATMSALRLARGYTGRNKILKFEGCYHGHGDSLLIKAGSGV ATLGLPDSPGVPEGIAKNTITVPYNDLESVKLAFQQFGEDIAGVIVEPVAGNMGVVPP QEGFLQGLRDITEQYGSLLIFDEVMTGFRVDYNCAQGYFGVTPDLTCLGKVIGGGLPV GAYGGKAEIMEQIAPSGPIYQAGTLSGNPLAMTAGLETLKQLTPESYKNFIKKGDRLE EGISKTAGAHGIPHTFNRAGSMIGFFFTNEPVINYETAKSSDLKLFASYYKGMANEGV FLPPSQFEGLFLSTAHTDEDIENTIQAAEKVFAEISRR*" gene complement(2693387..2694679) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" downshifts complement(2693404) /Source="Nicolas_upshifts" /id="D1440" /incds=0 /nref=144 /ntot=397 /MaxReadThrough="3.40168" /MaxDrop="7.29251" /score="3.77738386" /energy="-10.6" /TU="NA" /idTUdmin="U2177" /TUdmin="-5" /isTUend="TRUE" CDS complement(2694709..2695683) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" /EC_number="4.2.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 12029044, 15802251, 20823524, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 12029044, 15802251, 20823524, 24598743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-aminolevulinic acid dehydratase (porphobilinogen synthase)" /protein_id="NP_390691.1" /db_xref="EnsemblGenomes-Gn:BSU28130" /db_xref="EnsemblGenomes-Tr:CAB14773" /db_xref="GOA:P30950" /db_xref="InterPro:IPR001731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR030656" /db_xref="SubtiList:BG10344" /db_xref="UniProtKB/Swiss-Prot:P30950" /translation="MSQSFNRHRRLRTSKAMREMVKETRLHPSDFIYPIFVVEGLEGK KAVPSMPDVHHVSLDLLKDEVAELVKLGIQSVIVFGIPEEKDDCGTQAYHDHGIVQKA ITEIKEHFPEMVVVADTCLCEYTDHGHCGLVKDGVILNDESLELLAQTAVSQAKAGAD IIAPSNMMDGFVTVIREALDKEGFVNIPIMSYAVKYSSEFYGPFRDAANSTPQFGDRK TYQMDPANRMEALREAQSDVEEGADFLIVKPSLSYMDIMRDVKNEFTLPLVAYNVSGE YSMVKAAAQNGWIKEKEIVLEILTSMKRAGADLIITYHAKDAAKWLAE*" gene complement(2694709..2695683) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" CDS complement(2695680..2696468) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" /EC_number="4.2.1.75" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 2110138, 7628476, 12029044, 12196144, 15802251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 2110138, 7628476, 12029044, 12196144, 15802251; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III cosynthase" /protein_id="NP_390692.1" /db_xref="EnsemblGenomes-Gn:BSU28140" /db_xref="EnsemblGenomes-Tr:CAB14774" /db_xref="GOA:P21248" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG10343" /db_xref="UniProtKB/Swiss-Prot:P21248" /translation="MENDFPLKGKTVLVTRNKAQAASFQQKVEALGGKAVLTSLITFR RALPNDVAEQVREDLAAPGWLVFTSVNGADFFFSYLKENQLILPAHKKIAAVGEKTAR RLKMHNVSVDVMPQEYIAEQLADALKQHAEPGETITVMKGNLSRDVIKQELVPLGFEV KEWVLYETIPDEEGIEALKDAAGQYSFDYVTFTSSSTVHTFMHVLGEELKKWKANGTA CISIGPLTNDALLTYGITSHTPDTFTIDGMLELMCSMSREEERI*" gene complement(2695680..2696468) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" CDS complement(2696458..2697402) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" /EC_number="2.5.1.61" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 9058548, 12029044, 15802251, 23908040, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 9058548, 12029044, 15802251, 23908040, 24598743; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="porphobilinogen deaminase (hydroxymethylbilane synthase)" /protein_id="NP_390693.1" /db_xref="EnsemblGenomes-Gn:BSU28150" /db_xref="EnsemblGenomes-Tr:CAB14775" /db_xref="GOA:P16616" /db_xref="InterPro:IPR000860" /db_xref="InterPro:IPR022417" /db_xref="InterPro:IPR022418" /db_xref="InterPro:IPR022419" /db_xref="InterPro:IPR036803" /db_xref="SubtiList:BG10342" /db_xref="UniProtKB/Swiss-Prot:P16616" /translation="MMRTIKVGSRRSKLAMTQTKWVIQKLKEINPSFAFEIKEIVTKG DRIVDVTLSKVGGKGLFVKEIEQALLNEEIDMAVHSMKDMPAVLPEGLVIGCIPERED PRDALISKNRVKLSEMKKGAVIGTSSLRRSAQLLIERPDLTIKWIRGNIDTRLQKLET EDYDAIILAAAGLSRMGWKQDVVTEFLEPERCLPAVGQGALAIECRESDEELLALFSQ FTDEYTKRTVLAERAFLNAMEGGCQVPIAGYSVLNGQDEIEMTGLVASPDGKIIFKET VTGNDPEEVGKRCAALMADKGAKDLIDRVKRELDEDGK*" gene complement(2696458..2697402) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" CDS complement(2697435..2698265) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8012594, 12029044, 15802251, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012594, 12029044, 15802251, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="negative effector of the concentration of glutamyl-tRNA reductase HemA" /protein_id="NP_390694.2" /db_xref="EnsemblGenomes-Gn:BSU28160" /db_xref="EnsemblGenomes-Tr:CAB14776" /db_xref="GOA:P16645" /db_xref="InterPro:IPR002541" /db_xref="SubtiList:BG10341" /db_xref="UniProtKB/Swiss-Prot:P16645" /translation="MIDTAMARLNEGTIVIYALSVLFYFIDFLQHNRKAGKMAFWLLS IVWTLQTVYLAYFMWVTGRFPVLNVTEALYFYAWVLVTLSLVLTKLLRVDFIVFFTNV IGFSMIAIHTFSPTEQQSAAFSGQLVSELLVIHITMAILSYGAFSLSFVFSVLYMFQY HLLKKKKWGKWLLRIEDLSKLDYMAYVLNVIGVPMLLLSLILGVIWAYVSLETLYWFD AKVLGSFVVLLLYSYYLYIRLIKELQGKVAALWNTACFLVLMINYFLLGSLSQFHWFS *" gene complement(2697435..2698265) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" CDS complement(2698273..2699640) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" /EC_number="1.2.1.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1536660, 15802251, 1672867, 2490162, 12029044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1536660, 15802251, 1672867, 2490162, 12029044; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA reductase" /protein_id="NP_390695.1" /db_xref="EnsemblGenomes-Gn:BSU28170" /db_xref="EnsemblGenomes-Tr:CAB14777" /db_xref="GOA:P16618" /db_xref="InterPro:IPR000343" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR015895" /db_xref="InterPro:IPR015896" /db_xref="InterPro:IPR018214" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036343" /db_xref="InterPro:IPR036453" /db_xref="SubtiList:BG10340" /db_xref="UniProtKB/Swiss-Prot:P16618" /translation="MHILVVGVDYKSAPIEIREKVSFQPNELAEAMVQLKEEKSILEN IIVSTCNRTEIYAVVDQLHTGRYYIKKFLADWFQLSKEELSPFLTFYESDAAVEHLFR VACGLDSMVIGETQILGQVRDSFKTAQQEKTIGTIFNELFKQAVTVGKRTHAETDIGS NAVSVSYAAVELAKKIFGNLSSKHILILGAGKMGELAAENLHGQGIGKVTVINRTYLK AKELADRFSGEARSLNQLESALAEADILISSTGASEFVVSKEMMENANKLRKGRPLFM VDIAVPRDLDPALNDLEGVFLYDIDDLEGIVEANMKERRETAEKVELLIEETIVEFKQ WMNTLGVVPVISALREKALAIQSETMDSIERKLPHLSTREKKLLNKHTKSIINQMLRD PILKVKELAADADSEEKLALFMQIFDIEEAAGRQMMKTVESSQKVHSFKKAESKAGFS PLVSE*" gene complement(2698273..2699640) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" misc_feature complement(2699704..2699723) /Source="Nicolas_upshift_promotors" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2699710) /Source="Nicolas_upshifts" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" S_feature complement(2699712..2699801) /Source="Nicolas_S_feature" /locus_tag="new_2879205_2879294_c" /HighExp="dia15, Salt, dia5, Etha, Paraq, H2O2, Diami, Heat, LoTm, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigGF" /TUshortPSig="0.997, 1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1063" misc_feature 2699761..2699780 /Source="Nicolas_upshift_promotors" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2699769 /Source="Nicolas_upshifts" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2699798..2699817) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2699801) /Source="Nicolas_upshifts" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" S_feature complement(2699803..2700219) /Source="Nicolas_S_feature" /locus_tag="new_2879296_2879712_c" /HighExp="Etha, S5, Gly, S7, S4, S8, S6, H2O2, dia15, G135" /AntisenseName="ysxD" /AntisenseCor="-1.16761021676615E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF" /TUshortPSig="1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1064" promotor_-35 complement(2699828..2699836) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2699870..2700367 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390696.2" /db_xref="EnsemblGenomes-Gn:BSU28180" /db_xref="EnsemblGenomes-Tr:CAB14778" /db_xref="GOA:P40736" /db_xref="SubtiList:BG11068" /db_xref="UniProtKB/Swiss-Prot:P40736" /translation="MKQKSILFPCLLLAASVYAWLESGQAELFSGQDQWPVLLMLLGA AFVYQGKKEAVTPHFFIGLLLFGIGLHFFAKPKWVWWPDDFEMLLFMIGFSLLVSTVQ KKEYVYEAVSMICFSLFLYFFKQIMAWLESAHIPTALLKEYWPFVFIGISLLLLLIKR KKSIR*" gene 2699870..2700367 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" promotor_-10 complement(2700203..2700221) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2700219) /Source="Nicolas_upshifts" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" S_feature complement(2700221..2700351) /Source="Nicolas_S_feature" /locus_tag="new_2879714_2879844_c" /HighExp="S5, S4, S8, S6, H2O2, S7, Etha, dia15, Diami, G180" /AntisenseName="ysxD" /AntisenseCor="-1.18079537254433E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1065" promotor_-35 complement(2700237..2700243) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2700331..2700342) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-10" upshifts complement(2700351) /Source="Nicolas_upshifts" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" promotor_-35 complement(2700357..2700363) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-35" CDS complement(2700389..2700976) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome 50S subunit assembly(maturation of the central 50S protuberance)" /protein_id="NP_390697.1" /db_xref="EnsemblGenomes-Gn:BSU28190" /db_xref="EnsemblGenomes-Tr:CAB14779" /db_xref="GOA:P38424" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019987" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030393" /db_xref="PDB:1SUL" /db_xref="PDB:1SVI" /db_xref="PDB:1SVW" /db_xref="SubtiList:BG10339" /db_xref="UniProtKB/Swiss-Prot:P38424" /translation="MKVTKSEIVISAVKPEQYPEGGLPEIALAGRSNVGKSSFINSLI NRKNLARTSSKPGKTQTLNFYIINDELHFVDVPGYGFAKVSKSEREAWGRMIETYITT REELKAVVQIVDLRHAPSNDDVQMYEFLKYYGIPVIVIATKADKIPKGKWDKHAKVVR QTLNIDPEDELILFSSETKKGKDEAWGAIKKMINR*" gene complement(2700389..2700976) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" downshifts complement(2700417) /Source="Nicolas_upshifts" /id="D1441" /incds=0 /nref=78 /ntot=212 /MaxReadThrough="4.03888" /MaxDrop="6.16077" /score="19.8235959" /energy="-13.4" /TU="NA" /idTUdmin="U2182" /TUdmin=0 /isTUend="TRUE" CDS complement(2700973..2703297) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" /EC_number="3.4.21.53" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="class III heat-shock ATP-dependent LonA protease" /protein_id="NP_390698.1" /db_xref="EnsemblGenomes-Gn:BSU28200" /db_xref="EnsemblGenomes-Tr:CAB14780" /db_xref="GOA:P37945" /db_xref="InterPro:IPR003111" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004815" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027543" /db_xref="PDB:1X37" /db_xref="PDB:3M65" /db_xref="PDB:3M6A" /db_xref="SubtiList:BG10338" /db_xref="UniProtKB/Swiss-Prot:P37945" /translation="MAEELKRSIPLLPLRGLLVYPTMVLHLDVGRDKSVQALEQAMMH DHMIFLATQQDISIDEPGEDEIFTVGTYTKIKQMLKLPNGTIRVLVEGLKRAHIVKYN EHEDYTSVDIQLIHEDDSKDTEDEALMRTLLDHFDQYIKISKKISAETYAAVTDIEEP GRMADIVASHLPLKLKDKQDILETADVKDRLNKVIDFINNEKEVLEIEKKIGQRVKRS MERTQKEYYLREQMKAIQKELGDKEGKTGEVQTLTEKIEEAGMPDHVKETALKELNRY EKIPSSSAESSVIRNYIDWLVALPWTDETDDKLDLKEAGRLLDEEHHGLEKVKERILE YLAVQKLTKSLKGPILCLAGPPGVGKTSLAKSIAKSLGRKFVRISLGGVRDESEIRGH RRTYVGAMPGRIIQGMKKAGKLNPVFLLDEIDKMSSDFRGDPSSAMLEVLDPEQNSSF SDHYIEETFDLSKVLFIATANNLATIPGPLRDRMEIINIAGYTEIEKLEIVKDHLLPK QIKEHGLKKSNLQLRDQAILDIIRYYTREAGVRSLERQLAAICRKAAKAIVAEERKRI TVTEKNLQDFIGKRIFRYGQAETEDQVGVVTGLAYTTVGGDTLSIEVSLSPGKGKLIL TGKLGDVMRESAQAAFSYVRSKTEELGIEPDFHEKYDIHIHVPEGAVPKDGPSAGITM ATALVSALTGRAVSREVGMTGEITLRGRVLPIGGLKEKALGAHRAGLTTIIAPKDNEK DIEDIPESVREGLTFILASHLDEVLEHALVGEKK*" gene complement(2700973..2703297) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" S_feature complement(2703298..2703409) /Source="Nicolas_S_feature" /locus_tag="new_2882791_2882902_c" /HighExp="Etha, dia15, LBGtran, dia5, Diami, H2O2, LBGexp, Lbexp, LoTm, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.967" /TUlongSig="NA" /TUlongPSig="NA" /label="S1066" promotor_-10 complement(2703394..2703413) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2703409) /Source="Nicolas_upshifts" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" promotor_-35 complement(2703427..2703434) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2703478..2705136) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 18689473, 26428922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 18689473, 26428922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific ATP-dependent protease LonB" /protein_id="NP_390699.1" /db_xref="EnsemblGenomes-Gn:BSU28210" /db_xref="EnsemblGenomes-Tr:CAB14781" /db_xref="GOA:P42425" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014251" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11077" /db_xref="UniProtKB/Swiss-Prot:P42425" /translation="MSWTGIALFIQLFFGIIIGLYFWNLLKNQRTQKVTIDKESKKEM EQLRKMRAISLSEPLSEKVRPKSFKDIVGQEDGIKALKAALCGPNPQHVIVYGPPGVG KTAAARLVLEEAKKHKQSPFKEQAVFVELDATTARFDERGIADPLIGSVHDPIYQGAG AMGQAGIPQPKQGAVTHAHGGVLFIDEIGELHPIQMNKMLKVLEDRKVFLDSAYYSEE NTQIPNHIHDIFQNGLPADFRLIGATTRMPNEIPPAIRSRCLEVFFRELEKDELKTVA KTAADKIEKNISEEGLDLLTSYTRNGREAVNMIQIAAGMAVTENRKDITIEDIEWVIH SSQLTPKHEQKIGVEPQVGIVNGLAVYGPNSGSLLEIEVSVTAAQDKGSINITGIAEE ESIGSQSKSIRRKSMAKGSVENVLTVLRTMGMKPSDYDIHINFPGGIPIDGPSAGIAM AAGIFSAIHKIPIDNTVAMTGEISLNGLVKPIGGVIPKIKAAKQSGAKKVIIPYENQQ AILKQIDGIEIIAVKTFQEVLDEILVNPPTEQKPFHIEINKESV*" gene complement(2703478..2705136) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" downshifts complement(2703497) /Source="Nicolas_upshifts" /id="D1442" /incds=0 /nref=24 /ntot=42 /MaxReadThrough="2.32825" /MaxDrop="4.82102" /score="7.30551887" /energy="-7.1" /TU="NA" /idTUdmin="U2183" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2705180..2705198) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2705191) /Source="Nicolas_upshifts" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" promotor_-35 complement(2705214..2705219) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2705288..2706550) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein unfolding ATPase required for presentation of proteins to proteases; Maxwell's demon" /protein_id="NP_390700.2" /db_xref="EnsemblGenomes-Gn:BSU28220" /db_xref="EnsemblGenomes-Tr:CAB14782" /db_xref="GOA:P50866" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004487" /db_xref="InterPro:IPR010603" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11387" /db_xref="UniProtKB/Swiss-Prot:P50866" /translation="MFKFNEEKGQLKCSFCGKTQDQVRKLVAGPGVYICDECIELCTE IVEEELGTEEEVEFKDVPKPQEIREILNEYVIGQDQAKKSLAVAVYNHYKRINSNSKV DDVELSKSNISLIGPTGSGKTLLAQTLARILNVPFAIADATSLTEAGYVGEDVENILL KLIQAADYDVEKAEKGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVAS VPPQGGRKHPHQEFIQIDTTNILFICGGAFDGIEQIIKRRLGQKVIGFGADNKAADLE KEDLLSKVLPEDLLRFGLIPEFIGRLPVIASLEKLDEEALVAILTKPKNALVKQFKKM LELDNVELEFEEEALSEIAKKAIERKTGARGLRSIIEGIMLDVMFELPSRDDIEKCVI TGATVTHGEPPRLLLKDGTEVSQDKTSA*" gene complement(2705288..2706550) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" downshifts complement(2705298) /Source="Nicolas_upshifts" /id="D1443" /incds=0 /nref=256 /ntot=333 /MaxReadThrough="2.8818" /MaxDrop="7.82186" /score="40.299167" /energy="-18.9" /TU="U2185" /idTUdmin="U2184" /TUdmin="-19" /isTUend="TRUE" S_feature complement(2706551..2706640) /Source="Nicolas_S_feature" /locus_tag="new_2886044_2886133_c" /HighExp="dia15, dia5, Salt, Diami, C90, H2O2, Paraq, Oxctl, S1, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="1, 0.998, 0.896" /label="S1067" promotor_-10 complement(2706628..2706647) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2706640) /Source="Nicolas_upshifts" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" S_feature complement(2706642..2706773) /Source="Nicolas_S_feature" /locus_tag="new_2886135_2886266_c" /HighExp="H2O2, dia15, Paraq, Oxctl, G180, G135, HPh, G150, LPh, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1068" promotor_-35 complement(2706659..2706666) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2706818) /Source="Nicolas_upshifts" /id="D1444" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="8.26501" /MaxDrop="4.34985" /score="-0.284489083" /energy="-10.7" /TU="U2185,U2190" /idTUdmin="U2190" /TUdmin="-153" /isTUend="FALSE" CDS complement(2706822..2708096) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9748346, 12224648, 16156784, 17021213" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9748346, 12224648, 16156784, 17021213; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl isomerase (trigger factor)" /protein_id="NP_390701.1" /db_xref="EnsemblGenomes-Gn:BSU28230" /db_xref="EnsemblGenomes-Tr:CAB14783" /db_xref="GOA:P80698" /db_xref="InterPro:IPR001179" /db_xref="InterPro:IPR005215" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR008881" /db_xref="InterPro:IPR027304" /db_xref="InterPro:IPR036611" /db_xref="SubtiList:BG19023" /db_xref="UniProtKB/Swiss-Prot:P80698" /translation="MSVKWEKQEGNEGVLTVEVDAETFKTALDDAFKKVVKQVSIPGF RKGKIPRGLFEQRFGVEALYQDALDILLPVEYPKAVEEAGIEPVDRPEIDVEKIEKGE SLIFTAKVTVKPEVKLGEYKGLGIEKDDTTVTDEDVQNELKALQERQAELVVKEEGAV EEGNTVVLDFEGFVDGEAFEGGKAENYSLEVGSGSFIPGFEDQLVGLEAGAEKDVEVT FPEEYHAEDLAGKPAVFKVKIHEIKAKELPELDDEFAKDIDEEVETLAELTEKTKKRL EEAKENEADAKLREELVLKASENAEIDVPQAMVDTELDRMLKEFEQRLQMQGMNLELY TQFSGQDEAALKEQMKEDAEKRVKSNLTLEAIAKAENLEVSDEEVDAELTKMAEAYNM PVENIKQAIGSTDAMKEDLKVRKAIDFLVENR*" gene complement(2706822..2708096) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" S_feature complement(2708097..2708286) /Source="Nicolas_S_feature" /locus_tag="new_2887590_2887779_c" /HighExp="H2O2, HPh, BMM, dia15, T-4.40H, G180, Paraq, Oxctl, LBGexp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1069" promotor_-10 complement(2708273..2708292) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2708286) /Source="Nicolas_upshifts" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" promotor_-35 complement(2708307..2708311) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2708324..2709328) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390702.2" /db_xref="EnsemblGenomes-Gn:BSU28240" /db_xref="EnsemblGenomes-Tr:CAB14784" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12338" /db_xref="UniProtKB/Swiss-Prot:P94569" /translation="MTHDKKNAKIIPFPHLKDRLVEKGMSSLKEKKYQEALELFSEAM KYDDTESDLHLGMAICFLELGELEEAESVCEKMLKEGYGHYFTVLQVYMTILIQLKKY EEVKSTIEAVLEENQLPAESAEQFYKLLDFSRKMTDPDREDEAWAEEYEDTIDTEKVL ASPEEQMNLIHSLKDRNVAKYTGLLKTILQDPSAHPIIKTMIVMLLAEHEYSKPVHIS KFGESLTIEPSEIVPPDAAPILHRVLRVLDETLGNENPTLYAAVEELWRRHLYVLYPF QPKLLSADLWAAALHKVGYEMHGIEIESEELHMMYEFTDRELDEACTMLKDIEEISYL *" gene complement(2708324..2709328) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" promotor_-10 complement(2709353..2709372) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2709371) /Source="Nicolas_upshifts" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" promotor_-35 complement(2709384..2709391) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" CDS complement(2709447..2710046) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (small subunit)" /protein_id="NP_390703.1" /db_xref="EnsemblGenomes-Gn:BSU28250" /db_xref="EnsemblGenomes-Tr:CAB14785" /db_xref="GOA:P94568" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR004431" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR033940" /db_xref="SubtiList:BG11950" /db_xref="UniProtKB/Swiss-Prot:P94568" /translation="MEPLKSHTGKAAVLNRINVDTDQIIPKQFLKRIERTGYGRFAFF DWRYDANGEPNPEFELNQPVYQGASILIAGENFGCGSSREHAPWALDDYGFKIIIAPS FADIFHQNCFKNGMLPIRMPYDNWKQLVGQYENQSLQMTVDLENQLIHDSEGNQISFE VDPHWKEMLINGYDEISLTLLLEDEIKQFESQRSSWLQA*" gene complement(2709447..2710046) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" downshifts complement(2709468) /Source="Nicolas_upshifts" /id="D1445" /incds=0 /nref=5 /ntot=111 /MaxReadThrough="6.76876" /MaxDrop="3.81278" /score="12.2084487" /energy="-9.9" /TU="U2190,U2191" /idTUdmin="U2186" /TUdmin="-1176" /isTUend="FALSE" CDS complement(2710059..2711477) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (large subunit)" /protein_id="NP_390704.1" /db_xref="EnsemblGenomes-Gn:BSU28260" /db_xref="EnsemblGenomes-Tr:CAB14786" /db_xref="GOA:P80858" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR004430" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR033941" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG11949" /db_xref="UniProtKB/Swiss-Prot:P80858" /translation="MMPRTIIEKIWDQHIVKHGEGKPDLLYIDLHLIHEVTSPQAFEG LRQKGRKVRRPQNTFATMDHNIPTVNRFEIKDEVAKRQVTALERNCEEFGVRLADLHS VDQGIVHVVGPELGLTLPGKTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLSTQTLWQ QRPKTLEVRVDGTLQKGVTAKDVILAVIGKYGVKFGTGYVIEYTGEVFRNMTMDERMT VCNMSIEAGARAGLIAPDEVTFEYCKNRKYTPKGEEFDKAVEEWKALRTDPGAVYDKS IVLDGNKISPMVTWGINPGMVLPVDSEVPAPESFSAEDDKKEAIRAYEYMGLTPHQKI EDIKVEHVFIGSCTNSRMTDLRQAADMIKGKKVADSVRAIVVPGSQSVKLQAEKEGLD QIFLEAGFEWRESGCSMCLSMNNDVVPEGERCASTSNRNFEGRQGKGARTHLVSPAMA AMAAIHGHFVDVRKFYQEKTVV*" gene complement(2710059..2711477) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" promotor_-35 2711366..2711370 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2711385..2711389 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2711385 /Source="Nicolas_upshifts" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2711527..2712624) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" /EC_number="1.1.1.85" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10095787, 15228537, 15916605, 17389690" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10095787, 15228537, 15916605, 17389690; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydrogenase" /protein_id="NP_390705.2" /db_xref="EnsemblGenomes-Gn:BSU28270" /db_xref="EnsemblGenomes-Tr:CAB14787" /db_xref="GOA:P05645" /db_xref="InterPro:IPR004429" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG10675" /db_xref="UniProtKB/Swiss-Prot:P05645" /translation="MKKRIALLPGDGIGPEVLESATDVLKSVAERFNHEFEFEYGLIG GAAIDEHHNPLPEETVAACKNADAILLGAVGGPKWDQNPSELRPEKGLLSIRKQLDLF ANLRPVKVFESLSDASPLKKEYIDNVDFVIVRELTGGLYFGQPSKRYVNTEGEQEAVD TLFYKRTEIERVIREGFKMAAARKGKVTSVDKANVLESSRLWREVAEDVAQEFPDVKL EHMLVDNAAMQLIYAPNQFDVVVTENMFGDILSDEASMLTGSLGMLPSASLSSSGLHL FEPVHGSAPDIAGKGMANPFAAILSAAMLLRTSFGLEEEAKAVEDAVNKVLASGKRTR DLARSEEFSSTQAITEEVKAAIMSENTISNV*" gene complement(2711527..2712624) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" CDS complement(2712645..2714201) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" /EC_number="2.3.3.13" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 16330546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-isopropylmalate synthase" /protein_id="NP_390706.1" /db_xref="EnsemblGenomes-Gn:BSU28280" /db_xref="EnsemblGenomes-Tr:CAB14788" /db_xref="GOA:P94565" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR002034" /db_xref="InterPro:IPR005671" /db_xref="InterPro:IPR013709" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036230" /db_xref="SubtiList:BG11948" /db_xref="UniProtKB/Swiss-Prot:P94565" /translation="MRKINFFDTTLRDGEQSPGVNLNTQEKLAIAKQLERLGADIIEA GFPASSRGDFLAVQEIARTIKNCSVTGLARCVKGDIDAAWEALKDGAQPRIHVFIATS DIHLKHKLKMTREQVIERAVGMVKYAKERFPIVQWSAEDACRTELPFLAEIVEKVIDA GASVINLPDTVGYLAPAEYGNIFKYMKENVPNIHKAKLSAHCHDDLGMAVANSLAAIE NGADQIECAVNGIGERAGNAALEEIAVALHTRKDFYQVETGITLNEIKRTSDLVSKLT GMAVPRNKAVVGDNAFAHESGIHQDGFLKEKSTYEIISPELVGVTADALVLGKHSGRH AFKDRLTALGFQFDSEEINKFFTMFKELTEKKKEITDEDLVSLILEEKVTDRKIGYEF LSLQVHYGTSQVPTATLSLKNQENAQLIQEAATGAGSVEAIYNTLERCIDKDVELLDY RIQSNRKGEDAFAQVYVRVLVNGKESAGRGIAQDVLEASAKAYLNAVNRQLVFQSNMS GLKNHTAVGS*" gene complement(2712645..2714201) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" promotor_-35 2713041..2713044 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2713057..2715498 /Source="Nicolas_S_feature" /locus_tag="new_2892550_2894991" /HighExp="Lbstat, C30, T0.30H, M9-stat, T1.30H, H2O2, M0t90, T2.0H, Salt, BC" /AntisenseName="ilvC" /AntisenseCor="-0.51305153097242795" /AntisenseRegPval="-18.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1070" upshifts 2713057 /Source="Nicolas_upshifts" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" promotor_-10 2713059..2713078 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2714188..2715216) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" /EC_number="1.1.1.86" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 25393291, 25849365; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid isomeroreductase (NADP-dependent)" /protein_id="NP_390707.1" /db_xref="EnsemblGenomes-Gn:BSU28290" /db_xref="EnsemblGenomes-Tr:CAB14789" /db_xref="GOA:P37253" /db_xref="InterPro:IPR000506" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013023" /db_xref="InterPro:IPR013116" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR014359" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10672" /db_xref="UniProtKB/Swiss-Prot:P37253" /translation="MVKVYYNGDIKENVLAGKTVAVIGYGSQGHAHALNLKESGVDVI VGVRQGKSFTQAQEDGHKVFSVKEAAAQAEIIMVLLPDEQQQKVYEAEIKDELTAGKS LVFAHGFNVHFHQIVPPADVDVFLVAPKGPGHLVRRTYEQGAGVPALFAIYQDVTGEA RDKALAYAKGIGGARAGVLETTFKEETETDLFGEQAVLCGGLSALVKAGFETLTEAGY QPELAYFECLHELKLIVDLMYEEGLAGMRYSISDTAQWGDFVSGPRVVDAKVKESMKE VLKDIQNGTFAKEWIVENQVNRPRFNAINASENEHQIEVVGRKLREMMPFVKQGKKKE AVVSVAQN*" gene complement(2714188..2715216) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" CDS complement(2715240..2715758) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (small subunit)" /protein_id="NP_390708.2" /db_xref="EnsemblGenomes-Gn:BSU28300" /db_xref="EnsemblGenomes-Tr:CAB14790" /db_xref="GOA:P37252" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004789" /db_xref="InterPro:IPR019455" /db_xref="SubtiList:BG10671" /db_xref="UniProtKB/Swiss-Prot:P37252" /translation="MKRIITLTVVNRSGVLNRITGLFTKRHYNIESITVGHTETAGVS RITFVVHVEGENDVEQLTKQLNKQIDVLKVTDITNQSIVQRELALIKVVSAPSTRTEI NGIIEPFRASVVDVSRDSIVVQVTGESNKIEALIELLKPYGIKEIARTGTTAFARGTQ QKASSNKTISIV*" gene complement(2715240..2715758) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" promotor_-35 2715479..2715482 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2715498..2715502 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2715500 /Source="Nicolas_upshifts" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2715755..2717479) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (large subunit)" /protein_id="NP_390709.1" /db_xref="EnsemblGenomes-Gn:BSU28310" /db_xref="EnsemblGenomes-Tr:CAB14791" /db_xref="GOA:P37251" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012846" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10670" /db_xref="UniProtKB/Swiss-Prot:P37251" /translation="MGTNVQVDSASAECTQTMSGALMLIESLKKEKVEMIFGYPGGAV LPIYDKLYNSGLVHILPRHEQGAIHAAEGYARVSGKPGVVIATSGPGATNLVTGLADA MIDSLPLVVFTGQVATSVIGSDAFQEADILGITMPVTKHSYQVRQPEDLPRIIKEAFH IATTGRPGPVLIDIPKDVATIEGEFSYDHEMNLPGYQPTTEPNYLQIRKLVEAVSSAK KPVILAGAGVLHGKASEELKNYAEQQQIPVAHTLLGLGGFPADHPLFLGMAGMHGTYT ANMALHECDLLISIGARFDDRVTGNLKHFARNAKIAHIDIDPAEIGKIMKTQIPVVGD SKIVLQELIKQDGKQSDSSEWKKQLAEWKEEYPLWYVDNEEEGFKPQKLIEYIHQFTK GEAIVATDVGQHQMWSAQFYPFQKADKWVTSGGLGTMGFGLPAAIGAQLAEKDATVVA VVGDGGFQMTLQELDVIRELNLPVKVVILNNACLGMVRQWQEIFYEERYSESKFASQP DFVKLSEAYGIKGIRISSEAEAKEKLEEALTSREPVVIDVRVASEEKVFPMVAPGKGL HEMVGVKP*" gene complement(2715755..2717479) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" S_feature complement(2717480..2717600) /Source="Nicolas_S_feature" /locus_tag="new_2896973_2897093_c" /HighExp="T-5.40H, T-4.40H, S2, MG 120, Glucon, GM-0.2, T-2.40H, GM-0.1, HiOs, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1071" misc_RNA complement(2717601..2717847) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" /product="T-box controlling synthesis of branched chain amino acids" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" gene complement(2717601..2717847) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" downshifts complement(2717644) /Source="Nicolas_upshifts" /id="D1446" /incds=0 /nref=18 /ntot=78 /MaxReadThrough="7.67475" /MaxDrop="4.2339" /score="5.33237345" /energy="-13.8" /TU="U2190,U2191" /idTUdmin="U2195" /TUdmin=2682 /isTUend="FALSE" S_feature complement(2717848..2717974) /Source="Nicolas_S_feature" /locus_tag="new_2897341_2897467_c" /HighExp="LoTm, HiOs, T-3.40H, BC, B60, Pyr, GM 15, T-5.40H, UNK1, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1072" promotor_-10 complement(2717956..2717975) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-10" upshifts complement(2717974) /Source="Nicolas_upshifts" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" S_feature complement(2717976..2718106) /Source="Nicolas_S_feature" /locus_tag="new_2897469_2897599_c" /HighExp="Cold, S8, S0, S7, Mal, S6, G135, M9-stat, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1073" promotor_-35 complement(2717990..2717997) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-35" promotor_-10 complement(2718101..2718120) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2718110) /Source="Nicolas_upshifts" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" promotor_-35 complement(2718134..2718137) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" promotor_-35 2718232..2718241 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2718255..2718274 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2718257 /Source="Nicolas_upshifts" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" CDS 2718295..2718630 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_390710.1" /db_xref="EnsemblGenomes-Gn:BSU28320" /db_xref="EnsemblGenomes-Tr:CAB14792" /db_xref="SubtiList:BG12335" /db_xref="UniProtKB/Swiss-Prot:P94563" /translation="MNKSFADMQGFPAGFPSFPNFPQQYYPAVPPFYQQSQQPFGGYG YGQPFSQAYSPLTTPSGMYSSFPYASGFYGQQFSGAGFSGHGGSLSAPAIHAGGFSGA PGVHGGFRY*" gene 2718295..2718630 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" downshifts 2718624 /Source="Nicolas_upshifts" /id="D1447" /incds=0 /nref=14 /ntot=36 /MaxReadThrough="3.79194" /MaxDrop="6.48183" /score="11.836855" /energy="-13" /TU="U2192" /idTUdmin="U2193" /TUdmin="-220" /isTUend="FALSE" promotor_-35 2718711..2718718 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2718732..2718751 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2718734..2718798 /Source="Nicolas_S_feature" /locus_tag="new_2898227_2898291" /HighExp="S5, S6, S8, S7, B36, S4, S3, B60, BT, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.954, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1074" upshifts 2718734 /Source="Nicolas_upshifts" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" CDS 2718799..2719254 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17555270, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative indole acetic acid N-acetyltransferase" /protein_id="NP_390711.1" /db_xref="EnsemblGenomes-Gn:BSU28330" /db_xref="EnsemblGenomes-Tr:CAB14793" /db_xref="GOA:P94562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YX0" /db_xref="SubtiList:BG12336" /db_xref="UniProtKB/Swiss-Prot:P94562" /translation="MHIKIDDLTGRQVVSLVNEHLHSMTLMSPPESIHALGLEKLRGP EITFWSAWEGDELAGCGALKELDTRHGEIKSMRTSASHLRKGVAKQVLQHIIEEAEKR GYERLSLETGSMASFEPARKLYESFGFQYCEPFADYGEDPNSVFMTKKL*" gene 2718799..2719254 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" promotor_-35 2719362..2719368 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2719382..2719400 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2719389 /Source="Nicolas_upshifts" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" CDS 2719438..2720259 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 27464829; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative stress response protein" /protein_id="NP_390712.3" /db_xref="EnsemblGenomes-Gn:BSU28340" /db_xref="EnsemblGenomes-Tr:CAB14794" /db_xref="InterPro:IPR019060" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG12337" /db_xref="UniProtKB/Swiss-Prot:P94560" /translation="MKSIVGVYETPQETIAAIEGLLTKGYDSDDISVVTSRRDTDYLE SRTGTEVNQAIDAHQDESESFFDKLKDYFTMDDTATHSKALSDLDIKTDEIDKYQEDL DDGKLLVAVDTDADVIAPIDNGNALSGGFSSTNELDYTTKEEKTMPLREEQLKVDKED VQTGEVEIGKEVKTEKRDMDIPVRHDEIYVERRPVDENKTDAAPVNDSEEIRVPIVEE KLEVTKKPVVTDEVVVGKRTVEENEHISETVKKEEPRLNKEGKVDGLDDDPLNNK*" gene 2719438..2720259 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" downshifts 2720252 /Source="Nicolas_upshifts" /id="D1448" /incds=0 /nref=8 /ntot=77 /MaxReadThrough="2.49244" /MaxDrop="8.12771" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin="-21" /isTUend="TRUE" downshifts 2720316 /Source="Nicolas_upshifts" /id="D1449" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="1.26489" /MaxDrop="4.30778" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin=43 /isTUend="FALSE" tRNA complement(2720323..2720396) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg (UCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2720323..2720396) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" downshifts complement(2720357) /Source="Nicolas_upshifts" /id="D1450" /incds=0 /nref=34 /ntot=243 /MaxReadThrough="1.54905" /MaxDrop="4.72186" /score="24.0242272" /energy="-13.3" /TU="U2195,U2196" /idTUdmin="U2195" /TUdmin="-31" /isTUend="FALSE" promotor_-10 complement(2720433..2720452) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2720436) /Source="Nicolas_upshifts" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" promotor_-35 complement(2720466..2720473) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2720527..2721036) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" /EC_number="3.1.4.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390713.2" /db_xref="EnsemblGenomes-Gn:BSU28350" /db_xref="EnsemblGenomes-Tr:CAB14795" /db_xref="GOA:P94559" /db_xref="InterPro:IPR000979" /db_xref="InterPro:IPR020935" /db_xref="InterPro:IPR024654" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12334" /db_xref="UniProtKB/Swiss-Prot:P94559" /translation="MNVLIISDSHGLEEELQTIAKRHEAEVDLMIHCGDSELETRHPA LEPYAVVKGNCDFAGDFKDELLLTAGSRKILVTHGHLHGIKQTLLNVYYRAEELGADV ICFGHSHIAGSEVLRGKLMINPGSIRLPRVRRTESYAILTLENDAATVRFYDQAGNEI EDLQNRVTL*" gene complement(2720527..2721036) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" downshifts complement(2720544) /Source="Nicolas_upshifts" /id="D1451" /incds=0 /nref=87 /ntot=225 /MaxReadThrough="4.15666" /MaxDrop="5.59323" /score="24.0242272" /energy="-13.3" /TU="U2196,U2197" /idTUdmin="U2197" /TUdmin="-130" /isTUend="FALSE" CDS complement(2721052..2721648) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" /EC_number="3.6.1.66" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16322510, 17090528, 17976651, 18689515, 19943897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyinosine/deoxyxanthosine triphosphate pyrophosphatase, promiscuous (subunit A)" /protein_id="NP_390714.1" /db_xref="EnsemblGenomes-Gn:BSU28360" /db_xref="EnsemblGenomes-Tr:CAB14796" /db_xref="GOA:P94558" /db_xref="InterPro:IPR002637" /db_xref="InterPro:IPR020922" /db_xref="InterPro:IPR029001" /db_xref="SubtiList:BG12333" /db_xref="UniProtKB/Swiss-Prot:P94558" /translation="MIIMKEAIIATHNPGKVKEFKEILEPRGYDVKSLAEIGFTEEIE ETGHTFEENAIMKAEAVAKAVNKMVIADDSGLSIDNLGGRPGVYSARYAGEQKDDQAN IEKVLSELKGIEKEQRTARFRCALAVSIPGEETKTVEGHVEGYIAEEPRGEYGFGYDP IFIVKDKDKTMAELTSDEKNKISHRADALKKLSKLLEA*" gene complement(2721052..2721648) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" CDS complement(2721661..2722398) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" /EC_number="2.7.7.56" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1624460, 19153445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624460, 19153445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease PH" /protein_id="NP_390715.1" /db_xref="EnsemblGenomes-Gn:BSU28370" /db_xref="EnsemblGenomes-Tr:CAB14797" /db_xref="GOA:P28619" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR002381" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR018336" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="PDB:1OYP" /db_xref="PDB:1OYR" /db_xref="PDB:1OYS" /db_xref="SubtiList:BG10357" /db_xref="UniProtKB/Swiss-Prot:P28619" /translation="MRHDGRQHDELRPITFDLDFISHPEGSVLITAGNTKVICNASVE DRVPPFLRGGGKGWITAEYSMLPRATNQRTIRESSKGKISGRTMEIQRLIGRALRAVV DLEKLGERTIWIDCDVIQADGGTRTASITGAFLAMAIAIGKLIKAGTIKTNPITDFLA AISVGIDKEQGILLDLNYEEDSSAEVDMNVIMTGSGRFVELQGTGEEATFSREDLNGL LGLAEKGIQELIDKQKEVLGDSLPELK*" gene complement(2721661..2722398) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" promotor_-10 complement(2722480..2722499) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2722496) /Source="Nicolas_upshifts" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" CDS complement(2722509..2723609) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14662349, 27381174" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14662349, 27381174; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination (cortex hydrolysis) and sporulation (stage II, multiple polar septa) lytic enzyme" /protein_id="NP_390716.1" /db_xref="EnsemblGenomes-Gn:BSU28380" /db_xref="EnsemblGenomes-Tr:CAB14798" /db_xref="GOA:P39072" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10356" /db_xref="UniProtKB/Swiss-Prot:P39072" /translation="MLKKGPAVIGATCLTSALLLSGCGLFQSDKAAEEIDPPQDVTFV NDEAGANSNTTAAKKTESEKSDTAKADQASSTVMRELYLIDKNGYVVAQTLPLPKSES TAKQALEYLVQGGPVSEILPNGFRAVLPADTTVNVDIKKDGTAIADFSNEFKNYKKED EQKIVQSVTWTLTQFSSIDKVKLRINGHELKEMPVGGTPISDDLSRKDGINLETAGVN DLTATHPLTVYYLAENEDSEYYVPVTKRIDNSEKDDITAAINELAKGPSKVSGLLTDF SEDVKLVSKPKIKDGRVTLDFNQSIFGSADEKTKMISSEVLNSIVLTLTEQPDVKSVS VKVNGKSELVNEKGEKLTEPVSRPSQVNTGSF*" gene complement(2722509..2723609) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" promotor_-35 complement(2722514..2722519) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2722526) /Source="Nicolas_upshifts" /id="D1452" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="5.80816" /MaxDrop="4.3535" /score="41.5916163" /energy="-13" /TU="U2197" /idTUdmin="U2198" /TUdmin=1209 /isTUend="FALSE" promotor_-10 complement(2723632..2723650) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2723648) /Source="Nicolas_upshifts" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" promotor_-35 complement(2723665..2723670) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2723724..2724542) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" /EC_number="5.1.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15347750, 17610893, 17720142, 19309142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate racemase" /protein_id="NP_390717.2" /db_xref="EnsemblGenomes-Gn:BSU28390" /db_xref="EnsemblGenomes-Tr:CAB14799" /db_xref="GOA:P94556" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004391" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="PDB:1ZUW" /db_xref="SubtiList:BG11964" /db_xref="UniProtKB/Swiss-Prot:P94556" /translation="MLEQPIGVIDSGVGGLTVAKEIMRQLPKENIIYVGDTKRCPYGP RPEEEVLQYTWELTNYLLENHHIKMLVIACNTATAIALDDIQRSVGIPVVGVIQPGAR AAIKVTDNQHIGVIGTENTIKSNAYEEALLALNPDLKVENLACPLLVPFVESGKFLDK TADEIVKTSLYPLKDTSIDSLILGCTHYPILKEAIQRYMGEHVNIISSGDETAREVST ILSYKGLLNQSPIAPDHQFLTTGARDQFAKIADDWFGHEVGHVECISLQEPIKR*" gene complement(2723724..2724542) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" downshifts complement(2723736) /Source="Nicolas_upshifts" /id="D1453" /incds=0 /nref=230 /ntot=265 /MaxReadThrough="0.9265" /MaxDrop="6.72492" /score="41.5916163" /energy="-13" /TU="NA" /idTUdmin="U2198" /TUdmin="-1" /isTUend="TRUE" CDS complement(2724550..2724990) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26577401; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (mother cell's gene expression during sporulation)" /protein_id="NP_390718.1" /db_xref="EnsemblGenomes-Gn:BSU28400" /db_xref="EnsemblGenomes-Tr:CAB14800" /db_xref="GOA:P97247" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12332" /db_xref="UniProtKB/Swiss-Prot:P97247" /translation="MTSKPLEHVADIEKSLRHIAAIIKQKGREILNQYAITPPQFVGL QWLYELGDMTIGELSGKMYLACSTTTDLIDRMQKNELVERVKDPADRRVVRIHLLPEG ERIIQEVITKRQEYLRDMFESFTDEEIAIFEKSLMKLQHEMKRK*" gene complement(2724550..2724990) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" promotor_-10 complement(2725033..2725052) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2725042) /Source="Nicolas_upshifts" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" S_feature complement(2725044..2725186) /Source="Nicolas_S_feature" /locus_tag="new_2904537_2904679_c" /HighExp="BT, B36, S6, S8, S7, B60, Pyr, G/S, Lbtran, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.121047" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1075" promotor_-35 complement(2725068..2725072) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2725231) /Source="Nicolas_upshifts" /id="D1454" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="6.16749" /MaxDrop="4.6532" /score="20.9204638" /energy="-10.8" /TU="U2200,U2202" /idTUdmin="U2202" /TUdmin="-176" /isTUend="FALSE" CDS complement(2725234..2725458) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transcriptional regulator required for the expression of late spore coat genes" /protein_id="NP_390719.2" /db_xref="EnsemblGenomes-Gn:BSU28410" /db_xref="EnsemblGenomes-Tr:CAB14801" /db_xref="GOA:P11470" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1FSE" /db_xref="SubtiList:BG10355" /db_xref="UniProtKB/Swiss-Prot:P11470" /translation="MKEKEFQSKPLLTKREREVFELLVQDKTTKEIASELFISEKTVR NHISNAMQKLGVKGRSQAVVELLRMGELEL*" gene complement(2725234..2725458) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" upshifts 2725507 /Source="Nicolas_upshifts" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 2725509..2725527 /Source="Nicolas_upshift_promotors" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2725516..2725535) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2725536) /Source="Nicolas_upshifts" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" promotor_-35 complement(2725549..2725558) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2725574..2726017) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390720.1" /db_xref="EnsemblGenomes-Gn:BSU28420" /db_xref="EnsemblGenomes-Tr:CAB14802" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10354" /db_xref="UniProtKB/Swiss-Prot:P11469" /translation="MKLPAYIDMPFQEWKTSFSFFNKVSVRFSETDMFGHMNNVTPFI YFEEVRISYFKKLNMMSENKQTMTVVASQQCDYLRQVMPYEELRIYVKTSAVGSSSLT LHYLGENLEGEPCFTGAVVMVQVSKESGKAVSWTDEEKETLLHTR*" gene complement(2725574..2726017) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" CDS complement(2726078..2726839) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 22720735, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 22720735, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (iron-sulfur protein)" /protein_id="NP_390721.1" /db_xref="EnsemblGenomes-Gn:BSU28430" /db_xref="EnsemblGenomes-Tr:CAB14803" /db_xref="GOA:P08066" /db_xref="InterPro:IPR004489" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR025192" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG10353" /db_xref="UniProtKB/Swiss-Prot:P08066" /translation="MSEQKTIRFIITRQDTADSTPYDEEFEIPYRPNLNVISALMEIR RNPVNVKGEKTTPVTWDMNCLEEVCGACSMVINGKPRQSCTALIDQLEQPIRLKPMKT FPVVRDLQVDRSRMFDSLKKVKAWIPIDGTYDLGPGPRMPEKRRQWAYELSKCMTCGV CLEACPNVNSKSKFMGPAPMSQVRLFNAHPTGAMNKSERLEALMDEGGLADCGNSQNC VQSCPKGIPLTTSIAALNRDTNLQAFRNFFGSDRV*" gene complement(2726078..2726839) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" downshifts complement(2726086) /Source="Nicolas_upshifts" /id="D1455" /incds=0 /nref=61 /ntot=257 /MaxReadThrough="5.46426" /MaxDrop="4.6864" /score="20.9204638" /energy="-10.8" /TU="U2202" /idTUdmin="U2205" /TUdmin=1 /isTUend="TRUE" CDS complement(2726842..2728602) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 18535631, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 18535631, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (flavoprotein subunit)" /protein_id="NP_390722.2" /db_xref="EnsemblGenomes-Gn:BSU28440" /db_xref="EnsemblGenomes-Tr:CAB14804" /db_xref="GOA:P08065" /db_xref="InterPro:IPR003952" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR011280" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10352" /db_xref="UniProtKB/Swiss-Prot:P08065" /translation="MSQSSIIVVGGGLAGLMATIKAAESGMAVKLFSIVPVKRSHSVC AQGGINGAVNTKGEGDSPWEHFDDTVYGGDFLANQPPVKAMCEAAPSIIHLLDRMGVM FNRTPEGLLDFRRFGGTQHHRTAYAGATTGQQLLYALDEQVRRYEVAGLVTKYEGWEF LGAVLDDDRTCRGIVAQNLTNMQIESFRSDAVIMATGGPGIIFGKSTNSMINTGSAAS IVYQQGAYYANGEFIQIHPTAIPGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKY PAYGNLVPRDIATREIFDVCVNQKLGINGENMVYLDLSHKDPKELDIKLGGIIEIYEK FMGDDPRKLPMKIFPAVHYSMGGLWVDYDQMTNIPGLFAAGECDYSMHGGNRLGANSL LSAIYGGMVAGPNAVKYVNGLESSAEDMSSSLFDAHVKKEEEKWADIMSMDGTENAYV LHKELGEWMTANVTVVRHNDKLLKTDDKIQELMERFKKININDTTKWSNQGAMFTRQF SNMLQLARVITLGAYNRNESRGAHYKPDYPERNDDEWLKTTMAKHVSPYEAPEFEYQD VDVSLITPRKRDYSKKKVAK*" gene complement(2726842..2728602) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" CDS complement(2728636..2729244) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" /EC_number="1.3.5.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (cytochrome b558 subunit)" /protein_id="NP_390723.1" /db_xref="EnsemblGenomes-Gn:BSU28450" /db_xref="EnsemblGenomes-Tr:CAB14805" /db_xref="GOA:P08064" /db_xref="InterPro:IPR000701" /db_xref="InterPro:IPR011138" /db_xref="InterPro:IPR016002" /db_xref="InterPro:IPR034804" /db_xref="SubtiList:BG10351" /db_xref="UniProtKB/Swiss-Prot:P08064" /translation="MSGNREFYFRRLHSLLGVIPVGIFLIQHLVVNQFAARGAEAFNS AAHFMDSLPFRYALEIFIIFLPLIYHAVYGVYIAFTAKNNAGQYSYMRNWLFVLQRVT GIITLIFVSWHVWETRIAAQMGAEVNFDMMANILSSPAMLGFYIVGVLSTIFHFSNGL WSFAVTWGITVTPRSQRISTYVTLIIFVALSYVGLKAIFAFV*" gene complement(2728636..2729244) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" promotor_-35 2729014..2729021 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2729034..2729053 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2729036 /Source="Nicolas_upshifts" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2729245..2729340) /Source="Nicolas_S_feature" /locus_tag="new_2908738_2908833_c" /HighExp="Lbtran, dia5, Mt0, T0.30H, T1.0H, M0t90, M40t90, T0.0H, Glucon, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.78844099999999995" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1076" promotor_-10 complement(2729330..2729349) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-10" upshifts complement(2729340) /Source="Nicolas_upshifts" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" S_feature complement(2729342..2729963) /Source="Nicolas_S_feature" /locus_tag="new_2908835_2909456_c" /HighExp="MG 120, B36, UNK1, Fru, MG 150, BMM, Gly, Glucon, Glu, GM-0.1" /AntisenseName="yslB" /AntisenseCor="-0.44143968421748903" /AntisenseRegPval="-13.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1077" promotor_-35 complement(2729364..2729371) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-35" promotor_-35 2729479..2729483 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2729493..2729593 /Source="Nicolas_upshift_promotors" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2729500..2729519 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2729509 /Source="Nicolas_upshifts" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" CDS 2729537..2729983 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390724.1" /db_xref="EnsemblGenomes-Gn:BSU28460" /db_xref="EnsemblGenomes-Tr:CAB14806" /db_xref="InterPro:IPR019642" /db_xref="InterPro:IPR024096" /db_xref="PDB:3NJC" /db_xref="SubtiList:BG11236" /db_xref="UniProtKB/Swiss-Prot:P42955" /translation="MKSKFEASIDNLKEIEMNAYAYELIREIVLPDMLGQDYSSMMYW AGKHLARKFPLESWEEFPAFFEEAGWGTLTNVSAKKQELEFELEGPIISNRLKHQKEP CFQLEAGFIAEQIQLMNDQIAESYEQVKKRADKVVLTVKWDMKDPV*" gene 2729537..2729983 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" upshifts 2729553 /Source="Nicolas_upshifts" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" downshifts 2729971 /Source="Nicolas_upshifts" /id="D1456" /incds=0 /nref=217 /ntot=255 /MaxReadThrough="2.21897" /MaxDrop="6.5759" /score="4.74486914" /energy="-10.8" /TU="NA" /idTUdmin="U2203" /TUdmin=0 /isTUend="TRUE" downshifts complement(2730009) /Source="Nicolas_upshifts" /id="D1457" /incds=0 /nref=8 /ntot=160 /MaxReadThrough="5.89867" /MaxDrop="4.19639" /score="2.38159916" /energy="-10.8" /TU="U2205" /idTUdmin="U2206" /TUdmin=1270 /isTUend="FALSE" CDS complement(2730027..2731253) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2981221, 2981222, 14597663, 1980002, 8757727, 9851048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2981221, 2981222, 14597663, 1980002, 8757727, 9851048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II alpha subunit (aa 1->408)" /protein_id="NP_390725.1" /db_xref="EnsemblGenomes-Gn:BSU28470" /db_xref="EnsemblGenomes-Tr:CAB14807" /db_xref="GOA:P08495" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10350" /db_xref="UniProtKB/Swiss-Prot:P08495" /translation="MGLIVQKFGGTSVGSVEKIQNAANRAIAEKQKGHQVVVVVSAMG KSTDELVSLAKAISDQPSKREMDMLLATGEQVTISLLSMALQEKGYDAVSYTGWQAGI RTEAIHGNARITDIDTSVLADQLEKGKIVIVAGFQGMTEDCEITTLGRGGSDTTAVAL AAALKADKCDIYTDVPGVFTTDPRYVKSARKLEGISYDEMLELANLGAGVLHPRAVEF AKNYQVPLEVRSSTETEAGTLIEEESSMEQNLIVRGIAFEDQITRVTIYGLTSGLTTL STIFTTLAKRNINVDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIET ESKLAKVSIVGSGMVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAV ESLHDAFELSKHPSAV*" CDS complement(2730027..2730518) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1980002, 2981221, 2981222, 8757727, 9851048, 14597663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1980002, 2981221, 2981222, 8757727, 9851048, 14597663; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II beta subunit (aa 246->408)" /protein_id="YP_009513994.1" /translation="MEQNLIVRGIAFEDQITRVTIYGLTSGLTTLSTIFTTLAKRNIN VDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIETESKLAKVSIVGSG MVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAVESLHDAFELSKHP SAV*" gene complement(2730027..2731253) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" gene complement(2730027..2730518) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" downshifts complement(2731367) /Source="Nicolas_upshifts" /id="D1458" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="7.23315" /MaxDrop="4.15833" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=44 /isTUend="FALSE" misc_RNA complement(2731379..2731558) /gene="kswC" /locus_tag="BSU_misc_RNA_46" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:14523230, 14597663, 14627808, 21169337, 22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523230, 14597663, 14627808, 21169337, 22416067; Product type n: RNA" gene complement(2731379..2731558) /gene="kswC" /locus_tag="BSU_misc_RNA_46" downshifts complement(2731411) /Source="Nicolas_upshifts" /id="D1459" /incds=0 /nref=22 /ntot=132 /MaxReadThrough="7.09997" /MaxDrop="4.61976" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2731583..2731602) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-10" upshifts complement(2731590) /Source="Nicolas_upshifts" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" promotor_-35 complement(2731615..2731622) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-35" CDS complement(2731623..2733395) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" /EC_number="4.1.99.3" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8655545, 16267290, 16426634, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655545, 16267290, 16426634, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit C)" /protein_id="NP_390727.2" /db_xref="EnsemblGenomes-Gn:BSU28490" /db_xref="EnsemblGenomes-Tr:CAB14809" /db_xref="GOA:P14951" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR001162" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004791" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR035901" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10349" /db_xref="UniProtKB/Swiss-Prot:P14951" /translation="MNKQLKEKLALLPDQPGCYLMKDRQQTVIYVGKAKVLKNRVRSY FTGSHDAKTQRLVTEIEDFEYIVTSSNLEALILEMNLIKKHDPKYNVMLKDDKTYPFI KLTHERHPRLIVTRNVKKDKGRYFGPYPNVQAARETKKLLDRLYPLRKCSKLPDRVCL YYHLGQCLAPCVKDISEETNRELVESITRFLRGGYNEVKKELEEKMHEAAENLEFERA KELRDQIAHIESTMEKQKMTMNDLVDRDVFAYAYDKGWMCVQVFFIRQGKLIERDVSM FPLYQEADEEFLTFIGQFYSKNNHFLPKEILVPDSIDQSMIEQLLETNVHQPKKGPKK ELLMLAHKNAKIALKEKFSLIERDEERSIGAVQKLGEALNIYTPHRIEAFDNSNIQGT NPVSAMIVFIDGKPYKKEYRKYKIKTVTGPDDYGSMREVVRRRYTRVLRENLPLPDLI IIDGGKGQINAARDVIENELGLDIPIAGLAKDEKHRTSNLLIGDPLEVAYLERNSQEF YLLQRIQDEVHRFAISFHRQIRGKSAFQSVLDDIPGIGEKRKKMLLKHFGSVKKMKEA SLEDIKKAGVPAAAAQLLYDKLQK*" gene complement(2731623..2733395) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" promotor_-10 complement(2733422..2733441) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-10" upshifts complement(2733436) /Source="Nicolas_upshifts" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" promotor_-35 complement(2733455..2733462) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-35" downshifts complement(2733525) /Source="Nicolas_upshifts" /id="D1460" /incds=0 /nref=237 /ntot=268 /MaxReadThrough="4.77689" /MaxDrop="6.41061" /score="23.4086154" /energy="-10.5" /TU="U2207,U2208" /idTUdmin="U2209" /TUdmin=373 /isTUend="FALSE" CDS complement(2733531..2733845) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268; Product type c: carrier" /codon_start=1 /transl_table=11 /product="thioredoxin" /protein_id="NP_390728.1" /db_xref="EnsemblGenomes-Gn:BSU28500" /db_xref="EnsemblGenomes-Tr:CAB14810" /db_xref="GOA:P14949" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:2GZY" /db_xref="PDB:2GZZ" /db_xref="PDB:2IPA" /db_xref="PDB:2VOC" /db_xref="SubtiList:BG10348" /db_xref="UniProtKB/Swiss-Prot:P14949" /translation="MAIVKATDQSFSAETSEGVVLADFWAPWCGPCKMIAPVLEELDQ EMGDKLKIVKIDVDENQETAGKYGVMSIPTLLVLKDGEVVETSVGFKPKEALQELVNK HL*" gene complement(2733531..2733845) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" promotor_-10 complement(2733871..2733890) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2733885) /Source="Nicolas_upshifts" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" S_feature complement(2733887..2734096) /Source="Nicolas_S_feature" /locus_tag="new_2913380_2913589_c" /HighExp="Etha, Salt, Gly, Sw, M9-stat, LPhT, BC, B60, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984399999999996" /TUshortSig="SigB, SigA" /TUshortPSig="0.991, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1078" promotor_-35 complement(2733906..2733908) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2733990..2734100) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="CDS C-terminal fragment" /db_xref="PSEUDO:SOX90589.1" /translation="MVKYMTVKRRCDLMLRTILMIIGAIVVIGAIIRFVF*" gene complement(2733990..2734100) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /pseudo promotor_-10 complement(2734086..2734104) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-10" upshifts complement(2734096) /Source="Nicolas_upshifts" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" promotor_-35 complement(2734119..2734125) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-35" CDS complement(2734168..2735655) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 17827291, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 17827291, 18757805; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exo-alpha-L-arabinofuranosidase" /protein_id="NP_390729.2" /db_xref="EnsemblGenomes-Gn:BSU28510" /db_xref="EnsemblGenomes-Tr:CAB14811" /db_xref="GOA:P94552" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11985" /db_xref="UniProtKB/Swiss-Prot:P94552" /translation="MSEHQAVIQTDIAKGTINKNIYGHFAEHLGRGIYEGIWVGTDSD IPNINGIRKDVLEALKQLHIPVLRWPGGCFADEYHWANGVGDRKTMLNTHWGGTIESN EFGTHEFMMLCELLECEPYICGNVGSGTVQEMSEWIEYMTFEEGTPMSDWRKQNGREE PWKLKYFGVGNENWGCGGNMHPEYYADLYRRFQTYVRNYSGNDIYKIAGGANVDDFNW TDVLMKKAAGLMDGLSLHYYTIPGDFWKGKGSATEFTEDEWFITMKKAKYIDELIQKH GTIMDRYDPEQRVGLIIDEWGTWFDPEPGTNPGFLYQQNTIRDALVAASHFHIFHQHC RRVQMANIAQTVNVLQAMILTEGERMLLTPTYHVFNMFKVHQDASLLATETMSADYEW NGETLPQISISASKQAEGDINITICNIDHQNKAEAEIELRGLHKAADHSGVILTAEKM NAHNTFDDPHHVKPESFRQYTLSKNKLKVKLPPMSVVLLTLRADS*" gene complement(2734168..2735655) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" S_feature complement(2735656..2735768) /Source="Nicolas_S_feature" /locus_tag="new_2915149_2915261_c" /HighExp="T0.30H, M40t90, M0t90, BC, M9-stat, T1.30H, T1.0H, T2.0H, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1079" promotor_-10 complement(2735749..2735768) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-10" upshifts complement(2735768) /Source="Nicolas_upshifts" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" promotor_-35 complement(2735783..2735790) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-35" CDS complement(2735872..2736849) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 20059546, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 20059546, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (alpha subunit)" /protein_id="NP_390730.1" /db_xref="EnsemblGenomes-Gn:BSU28520" /db_xref="EnsemblGenomes-Tr:CAB14812" /db_xref="GOA:P94551" /db_xref="InterPro:IPR001308" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR014731" /db_xref="InterPro:IPR018206" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR033947" /db_xref="SubtiList:BG11934" /db_xref="UniProtKB/Swiss-Prot:P94551" /translation="MGKKVIVLGEIRDGELRNVTFEAIAAGRTISGDGEVIGVLIGEN VQSIAQELIHYGADKVLTAEDPKLKTYTADGYSQVMRGVIEQENPDSVIFGHTAMGKD LSPKLAARLQTGLISDAIDVSVTGGNVVFTRPIYSGKAFERVISTDPMIFATIRPNNI QASEKDTSRSGSIESIDVSLTDLRTVIQEVVKKTADGVDLSEAKIIVAGGRGVKSKEG FQPLQELAEVLGAAVGASRGACDADYCDYALQIGQTGKVVTPDLYIACGISGAIQHLA GMSNSKVIVAINKDPEADIFKIADYGIVGDLFEVVPLLTEEFKQLNIHS*" gene complement(2735872..2736849) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" downshifts complement(2735880) /Source="Nicolas_upshifts" /id="D1461" /incds=0 /nref=58 /ntot=179 /MaxReadThrough="2.43782" /MaxDrop="7.95053" /score="30.2462458" /energy="-13.5" /TU="NA" /idTUdmin="U2210" /TUdmin="-2" /isTUend="TRUE" CDS complement(2736885..2737658) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10026281, 17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10026281, 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (beta subunit)" /protein_id="NP_390731.1" /db_xref="EnsemblGenomes-Gn:BSU28530" /db_xref="EnsemblGenomes-Tr:CAB14813" /db_xref="GOA:P94550" /db_xref="InterPro:IPR000049" /db_xref="InterPro:IPR012255" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR033948" /db_xref="SubtiList:BG11935" /db_xref="UniProtKB/Swiss-Prot:P94550" /translation="MNLFVLMKRTFDTEEKIVIETGKIQDDGAEWIINPYDEYAIEEA IQLKEKHGGTITAVTVGGEEAEKELRTALAMGCDQAVLINIEDDLDEPDQYSISQVLY HYMKDQEFDLILGGNVAIDGGSGQVAPRLAELLDIPCITTITKLEINGTDAEAERDVE GDVEKIKTTLPLLVTAQQGLNEPRYPSLPGIMKAKKKPLEELELDDLDLDEEDAEPKL KTIERFLPPKKEAGKLLQGEPAEQAKELVSLLRSEAKVI*" gene complement(2736885..2737658) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" CDS complement(2737673..2738449) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-CoA hydratase" /protein_id="NP_390732.1" /db_xref="EnsemblGenomes-Gn:BSU28540" /db_xref="EnsemblGenomes-Tr:CAB14814" /db_xref="GOA:P94549" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12331" /db_xref="UniProtKB/Swiss-Prot:P94549" /translation="MNAISLAVDQFVAVLTIHNPPANALSSRILEELSSCLDQCETDA GVRSIIIHGEGRFFSAGADIKEFTSLKGNEDSSLLAERGQQLMERIESFPKPIIAAIH GAALGGGLELAMACHIRIAAEDAKLGLPELNLGIIPGFAGTQRLPRYVGTAKALELIG SGEPISGKEALDLGLVSIGAKDEAEVIEKAKALAAKFAEKSPQTLASLLELLYSNKVY SYEGSLKLEAKRFGEAFESEDAKEGIQAFLEKRKPQFKGE*" gene complement(2737673..2738449) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" downshifts 2737738 /Source="Nicolas_upshifts" /id="D1462" /incds=1 /nref=1 /ntot=21 /MaxReadThrough="0.92259" /MaxDrop="4.42725" /score="-8.29305955" /energy="-5.1" /TU="NA" /idTUdmin="U2203" /TUdmin=7767 /isTUend="FALSE" CDS complement(2738464..2739048) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17189250, 18941141, 21398533, 24356978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 18941141, 21398533, 24356978; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of fatty acids degradation [FadR-long-chain (C14-C20) acyl-CoAs]" /protein_id="NP_390733.1" /db_xref="EnsemblGenomes-Gn:BSU28550" /db_xref="EnsemblGenomes-Tr:CAB14815" /db_xref="GOA:P94548" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013570" /db_xref="InterPro:IPR036271" /db_xref="PDB:1VI0" /db_xref="PDB:3WHB" /db_xref="PDB:3WHC" /db_xref="SubtiList:BG12330" /db_xref="UniProtKB/Swiss-Prot:P94548" /translation="MKQKRPKYMQIIDAAVEVIAENGYHQSQVSKIAKQAGVADGTIY LYFKNKEDILISLFKEKMGQFIERMEEDIKEKATAKEKLALVISKHFSLLAGDHNLAI VTQLELRQSNLELRQKINEILKGYLNILDGILTEGIQSGEIKEGLDVRLARQMIFGTI DETVTTWVMNDQKYDLVALSNSVLELLVSGIHNK*" gene complement(2738464..2739048) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" promotor_-10 complement(2739090..2739109) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2739090) /Source="Nicolas_upshifts" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" promotor_-35 complement(2739122..2739129) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2739153..2740835) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17085570, 17189250, 21398533, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17085570, 17189250, 21398533, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long chain acyl-CoA ligase (degradative)" /protein_id="NP_390734.1" /db_xref="EnsemblGenomes-Gn:BSU28560" /db_xref="EnsemblGenomes-Tr:CAB14816" /db_xref="GOA:P94547" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG11946" /db_xref="UniProtKB/Swiss-Prot:P94547" /translation="MQSQKPWLAEYPNDIPHELPLPNKTLQSILTDSAARFPDKTAIS FYGKKLTFHDILTDALKLAAFLQCNGLQKGDRVAVMLPNCPQTVISYYGVLFAGGIVV QTNPLYTEHELEYQLRDAQVSVIITLDLLFPKAIKMKTLSIVDQILITSVKDYLPFPK NILYPLTQKQKVHIDFDKTANIHTFASCMKQEKTELLTIPKIDPEHDIAVLQYTGGTT GAPKGVMLTHQNILANTEMCAAWMYDVKEGAEKVLGIVPFFHVYGLTAVMNYSIKLGF EMILLPKFDPLETLKIIDKHKPTLFPGAPTIYIGLLHHPELQHYDLSSIKSCLSGSAA LPVEVKQKFEKVTGGKLVEGYGLSEASPVTHANFIWGKNKPGSIGCPWPSTDAAIYSE ETGELAAPYEHGEIIVKGPQVMKGYWNKPEETAAVLRDGWLFTGDMGYMDEEGFFYIA DRKKDIIIAGGYNIYPREVEEALYEHEAIQEIVVAGVPDSYRGETVKAFVVLKKGAKA DTEELDAFARSRLAPYKVPKAYEFRKELPKTAVGKILRRRLLEEETENHHIK*" gene complement(2739153..2740835) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" misc_feature complement(2740864..2740883) /Source="Nicolas_upshift_promotors" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2740872) /Source="Nicolas_upshifts" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" downshifts complement(2740960) /Source="Nicolas_upshifts" /id="D1463" /incds=0 /nref=8 /ntot=101 /MaxReadThrough="2.17789" /MaxDrop="3.3655" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-22" /isTUend="TRUE" CDS complement(2741024..2741428) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390735.1" /db_xref="EnsemblGenomes-Gn:BSU28570" /db_xref="EnsemblGenomes-Tr:CAB14817" /db_xref="GOA:P94546" /db_xref="InterPro:IPR007140" /db_xref="SubtiList:BG12329" /db_xref="UniProtKB/Swiss-Prot:P94546" /translation="MSDFWENELVEIAAYYSVAVLCLVLFLTVFELVTAYKNWEEIQK GNLAVAMATGGKILGIANVFQHSISQHNSLLQMIGWGVYGFVMLLISYFIFEFLTPRF KIDQEIENDNRAVGFISFVISVGLSFVVAAGI*" gene complement(2741024..2741428) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" downshifts complement(2741026) /Source="Nicolas_upshifts" /id="D1464" /incds=0 /nref=1 /ntot=75 /MaxReadThrough="3.74343" /MaxDrop="2.92029" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-88" /isTUend="FALSE" CDS complement(2741443..2743800) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11254128, 12719520, 22333191, 27799325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254128, 12719520, 22333191, 27799325; Product type f: factor" /codon_start=1 /transl_table=11 /product="homologous recombination factor" /protein_id="NP_390736.1" /db_xref="EnsemblGenomes-Gn:BSU28580" /db_xref="EnsemblGenomes-Tr:CAB14818" /db_xref="GOA:P94545" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR002625" /db_xref="InterPro:IPR005747" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036063" /db_xref="InterPro:IPR036187" /db_xref="SubtiList:BG12328" /db_xref="UniProtKB/Swiss-Prot:P94545" /translation="MQQKVLSALEFHKVKEQVIGHAASSLGKEMLLELKPSASIDEIK KQLDEVDEASDIIRLRGQAPFGGLVDIRGALRRAEIGSVLSPSEFTEISGLLYAVKQM KHFITQMAEDGVDIPLIHQHAEQLITLSDLERDINSCIDDHGEVLDHASETLRGIRTQ LRTLESRVRDRLESMLRSSSASKMLSDTIVTIRNDRFVIPVKQEYRSSYGGIVHDTSS SGATLFIEPQAIVDMNNSLQQAKVKEKQEIERILRVLTEKTAEYTEELFLDLQVLQTL DFIFAKARYAKAVKATKPIMNDTGFIRLKKARHPLLPPDQVVANDIELGRDFSTIVIT GPNTGGKTVTLKTLGLLTLMAQSGLHIPADEGSEAAVFEHVFADIGDEQSIEQSLSTF SSHMVNIVGILEQVNENSLVLFDELGAGTDPQEGAALAMSILDDVHRTNARVLATTHY PELKAYGYNREGVMNASVEFDIETLSPTYKLLIGVPGRSNAFEISKRLGLPDHIIGQA KSEMTAEHNEVDTMIASLEQSKKRAEEELSETESIRKEAEKLHKELQQQIIELNSKKD KMLEEAEQQAAEKVKAAMKEAEDIIHELRTIKEEHKSFKDHELINAKKRLEGAMPAFE KSKKPEKPKTQKRDFKPGDEVKVLTFGQKGTLLEKTGGNEWNVQIGILKMKVKEKDLE FIKSAPEPKKEKMITAVKGKDYHVSLELDLRGERYENALSRVEKYLDDAVLAGYPRVS IIHGKGTGALRKGVQDLLKNHRSVKSSRFGEAGEGGSGVTVVELK*" gene complement(2741443..2743800) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" CDS complement(2743821..2745533) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" /EC_number="2.7.7.7" /EC_number="3.1.11.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:18776221, 18938175, 28254425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18776221, 18938175, 28254425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase/3'-5' exonuclease X" /protein_id="NP_390737.1" /db_xref="EnsemblGenomes-Gn:BSU28590" /db_xref="EnsemblGenomes-Tr:CAB14819" /db_xref="GOA:P94544" /db_xref="InterPro:IPR002054" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010996" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR022311" /db_xref="InterPro:IPR027421" /db_xref="InterPro:IPR029398" /db_xref="InterPro:IPR037160" /db_xref="SubtiList:BG12327" /db_xref="UniProtKB/Swiss-Prot:P94544" /translation="MHKKDIIRLLETIAVYMELKGDNPFKVSAFRKAAAALEQDDRSL SEMDDMMSLSGIGKGTYSVIKEYIDEGKSSTLESLQKEVPEGLVPLLKLPGLGGKKIA KLYKELGVHDAESLKEACEQQKVQGLAGFGKKSEEKILQALGEAGKQPERFPIGYALR IAREIEEHLSQFTHIIKFSRAGSLRRARETVKDLDYIIATDHPAEVREQLLELPNIKS VIASGDTKVSVILSFEYETSVDFRLVTEEQFPTTLHHFTGSKDHNIKMRQIAKERGER ISEYGVETVETGEIKTFPSEREFYAHFGLPLIPPEIRESGQEVETYSDSIELIELGQI KGDLHMHSTWSDGAFSIREMAEACIKKGYQYMAITDHSQYLKVANGLTAERLKQQAKE IDALNAEFENFRILKGVEMDILPDGTLDYDDDVLAEMDIVIASIHSSFNQPEHVIMKR LETALTNKHVDIIAHPTGRLIGRRAGYEIDIDQLIELARKTNTALELNANPARLDLRT EHLMKANEQGVTLVINTDAHNIEMLDDMKTGVTAARKGWTETKNVLNARSLKDVEAFL KRND*" gene complement(2743821..2745533) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" S_feature complement(2745534..2745606) /Source="Nicolas_S_feature" /locus_tag="new_2925027_2925099_c" /HighExp="Cold, LPhT, LBGstat, H2O2, dia15, G180, G135, Sw, G150, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1080" CDS complement(2745607..2746140) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390738.1" /db_xref="EnsemblGenomes-Gn:BSU28600" /db_xref="EnsemblGenomes-Tr:CAB14820" /db_xref="GOA:P94543" /db_xref="InterPro:IPR003825" /db_xref="SubtiList:BG12326" /db_xref="UniProtKB/Swiss-Prot:P94543" /translation="MLDIIILILLLMGTLLGLKRGFILQFIRLTSFILSIAFAALFYK NVAPHLHWIPAPDFSAGQPALSFFTGNLEAAYYNAIAFIVLFIIAKILLRIIGSFLSI VAGIPVIKQINQMLGAVLGFLEVYLFTFVLLYVASVLPVDALQQMMGQSSLANVIINH TPYLSGLLQELWTQYGA*" gene complement(2745607..2746140) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" CDS complement(2746147..2746404) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" /experiment="publication(s) with functional evidences, PMID:15317782, 16796675, 18588879, 20711458, 24097947, 26258635" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317782, 16796675, 18588879, 20711458, 24097947, 26258635; Product type r : regulator" /codon_start=1 /transl_table=11 /product="regulator of cell division" /protein_id="NP_390739.1" /db_xref="EnsemblGenomes-Gn:BSU28610" /db_xref="EnsemblGenomes-Tr:CAB14821" /db_xref="GOA:P94542" /db_xref="InterPro:IPR007838" /db_xref="InterPro:IPR023688" /db_xref="InterPro:IPR036192" /db_xref="SubtiList:BG12325" /db_xref="UniProtKB/Swiss-Prot:P94542" /translation="MSDGKKTKTTVDIYGQHFTIVGEESRAHMRYVAGIVDDKMREIN EKNPYLDINKLAVLTAVNVVHDYVKLQEKCEKLERQLKEKD*" gene complement(2746147..2746404) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" promotor_-10 complement(2746431..2746450) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2746447) /Source="Nicolas_upshifts" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" promotor_-35 complement(2746462..2746469) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2746487..2746506 /Source="Nicolas_upshift_promotors" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2746494 /Source="Nicolas_upshifts" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" CDS 2746538..2747479 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" /EC_number="3.1.26.4" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9888800, 10094689, 12794188, 23882084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888800, 10094689, 12794188, 23882084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HIII" /protein_id="NP_390740.1" /db_xref="EnsemblGenomes-Gn:BSU28620" /db_xref="EnsemblGenomes-Tr:CAB14822" /db_xref="GOA:P94541" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR004641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR024568" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12324" /db_xref="UniProtKB/Swiss-Prot:P94541" /translation="MSHSVIKVSLSAIDQMKMTYSGSLTASVPQGAVFQAKPPGCTIT AYQSGKVLFQGKNAAAESARWGTAEPQEKKKTAKKPADPRYAPPADIAGMSVIGSDEV GTGDYFGPMTVVCAYVDKTMLPLMKELGVKDSKDLKDPQIIEIARNLIKTIPYSLLVL KNEKYNSMQEKGMSQGKMKALLHNQAITHLLRKLDGVKPEAILIDQFAEPGVYFNHLK GRDIVKERTYFSTKAEGIHLAVAAASIIARYSFLMEMDKLSRAAGMTLPKGAGPHVDE AAAKLILKKGASALRTFTKLHFANTQKAQRLADKKRS*" gene 2746538..2747479 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" promotor_-10 complement(2747211..2747230) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2747226) /Source="Nicolas_upshifts" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2747244..2747251) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2747462 /Source="Nicolas_upshifts" /id="D1465" /incds=0 /nref=150 /ntot=232 /MaxReadThrough="1.71535" /MaxDrop="5.25365" /score="25.6336933" /energy="-13.7" /TU="NA" /idTUdmin="U2213" /TUdmin=0 /isTUend="TRUE" downshifts complement(2747494) /Source="Nicolas_upshifts" /id="D1466" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.4685" /MaxDrop="5.29665" /score="-4.45611985" /energy="-14.9" /TU="NA" /idTUdmin="U2216" /TUdmin=44 /isTUend="FALSE" CDS complement(2747515..2749929) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (beta subunit)" /protein_id="NP_390741.1" /db_xref="EnsemblGenomes-Gn:BSU28630" /db_xref="EnsemblGenomes-Tr:CAB14823" /db_xref="GOA:P17922" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004532" /db_xref="InterPro:IPR005121" /db_xref="InterPro:IPR005146" /db_xref="InterPro:IPR005147" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020825" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR036690" /db_xref="SubtiList:BG10875" /db_xref="UniProtKB/Swiss-Prot:P17922" /translation="MFVSYKWLEDYVDLKGMDPAVLAEKITRAGIEVEGIEYKGEGIK GVVIGHVLEREQHPNADKLNKCLVDIGAEAPVQIICGAPNVDKGQKVAVATVGAVLPG NFKIKKAKLRGEESNGMICSLQELGIESKLVAKEYAEGIFVFPNDAETGSDALAALQL DDAILELGLTPNRADAMNMLGVAYEVAAILDTEVKLPQTDYPAASEQASDYISVKIED QEANPLYTAKIIKNVTIAPSPLWMQTKLMNAGIRPHNNVVDITNFVLLEYGQPLHAFD YDRFGSKEVVVRKAAENEMIVTLDDQERKLSADHLVITNGTKAQAVAGVMGGAESEVQ EDTKTILLEAAYFNGQKVRKASKDLGLRSESSVRFEKGIDPARVRLAAERAAQLIHLY AGGEVLAGTVEEDHLTIEANNIHVSADKVSSVLGLTISKEELISIYKRLGFTVGEADD LLVVTVPSRRGDITIEEDLIEEAARLYGYDNIPSTLPETAGTTGGLTPYQAKRRKVRR FLEGAGLSQAITYSLTNEKKATAFAIEKSLNTVLALPMSEERSILRHSLVPNLLDSVS YNLARQTDSVALYEVGSVFLTKEEDTKPVETERVAGAVTGLWRKQLWQGEKKPVDFFV VKGIVEGLLDKLNVLDSIEFVQSERKQLHPGRTANILLNGSLIGFIGQVHPSLEKELD IKETYVFELDLHALLAAETAPLVYTAIPKYPSVTRDIALVTDKTVTSGQLESVIKEAG GKLLKEVTVFDVYEGEHMEEGKKSVAFSLQYVNPEQTLTEEEVTKAHSKVLKALEDTY QAVLRG*" gene complement(2747515..2749929) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" downshifts complement(2747538) /Source="Nicolas_upshifts" /id="D1467" /incds=0 /nref=214 /ntot=255 /MaxReadThrough="3.98669" /MaxDrop="7.11892" /score="32.4736491" /energy="-14.7" /TU="NA" /idTUdmin="U2216" /TUdmin=0 /isTUend="TRUE" CDS complement(2749945..2750979) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390742.1" /db_xref="EnsemblGenomes-Gn:BSU28640" /db_xref="EnsemblGenomes-Tr:CAB14824" /db_xref="GOA:P17921" /db_xref="InterPro:IPR002319" /db_xref="InterPro:IPR004188" /db_xref="InterPro:IPR004529" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR022911" /db_xref="SubtiList:BG10874" /db_xref="UniProtKB/Swiss-Prot:P17921" /translation="MEEKLKQLEQEALEQVEAASSLKVVNDIRVQYLGKKGPITEVLR GMGKLSAEERPKMGALANEVRERIANAIADKNEKLEEEEMKQKLAGQTIDVTLPGNPV AVGGRHPLTVVIEEIEDLFIGMGYTVEEGPEVETDYYNFESLNLPKEHPARDMQDSFY ITEETLMRTQTSPVQTRTMEKHEGKGPVKIICPGKVYRRDNDDATHSHQFMQIEGLVV DKNISMSDLKGTLELVAKKMFGQDREIRLRPSFFPFTEPSVEVDVTCFKCGGNGCSVC KGTGWIEILGAGMVHPNVLKMAGFDPKEYQGFAFGMGVERIAMLKYGIDDIRHFYTND VRFISQFKQA*" gene complement(2749945..2750979) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" S_feature complement(2750980..2751300) /Source="Nicolas_S_feature" /locus_tag="new_2930473_2930793_c" /HighExp="HPh, Cold, GM 15, GM 10, Sw, C30, G150, MG-0.2, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1081" CDS 2751061..2751267 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513995.1" /translation="MWPRYHPYFRQTDAVVSFIDITESDSGSPLRAVYAVPATTQEVK PISGCVKNALSQRHFLPGKQLIRN*" gene 2751061..2751267 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" S_feature 2751290..2751554 /Source="Nicolas_S_feature" /locus_tag="new_2930783_2931047" /HighExp="S8, S7, S6, BT, C30, B36, S5, Pyr, C90, Glucon" /AntisenseName="ysgA" /AntisenseCor="-0.23049778674462801" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.519" /TUlongSig="NA" /TUlongPSig="NA" /label="S1082" upshifts 2751290 /Source="Nicolas_upshifts" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" promotor_-10 complement(2751295..2751314) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2751297..2751311 /Source="Nicolas_upshift_promotors" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2751300) /Source="Nicolas_upshifts" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" promotor_-35 complement(2751329..2751332) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2751334..2752080) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 24809820, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal RNA methylase" /protein_id="NP_390743.1" /db_xref="EnsemblGenomes-Gn:BSU28650" /db_xref="EnsemblGenomes-Tr:CAB14825" /db_xref="GOA:P94538" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG12323" /db_xref="UniProtKB/Swiss-Prot:P94538" /translation="MKQIESAKNQKVKDWKKLHTKKERTKTNTFLIEGEHLVEEALKS PGIVKEILVKDETRIPSDLETGIQCYMLSEDAFSAVTETETPQQIAAVCHMPEEKLAT ARKVLLIDAVQDPGNLGTMIRTADAAGLDAVVLGDGTADAFNGKTLRSAQGSHFHIPV VRRNLPSYVDELKAEGVKVYGTALQNGAPYQEIPQSESFALIVGNEGAGVDAALLEKT DLNLYVPLYGQAESLNVAVAAAILVYHLRG*" gene complement(2751334..2752080) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" promotor_-10 complement(2752107..2752126) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-10" promotor_-35 2752113..2752119 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2752120) /Source="Nicolas_upshifts" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" promotor_-10 2752133..2752144 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2752140..2752146) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-35" upshifts 2752147 /Source="Nicolas_upshifts" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" CDS 2752199..2752414 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8171126, 10806362, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8171126, 10806362, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_390744.1" /db_xref="EnsemblGenomes-Gn:BSU28660" /db_xref="EnsemblGenomes-Tr:CAB14826" /db_xref="GOA:P94537" /db_xref="InterPro:IPR017525" /db_xref="SubtiList:BG12318" /db_xref="UniProtKB/Swiss-Prot:P94537" /translation="MDLNLRHAVIANVTGNNQEQLEHTIVDAIQSGEEKMLPGLGVLF EVIWQHASESEKNEMLKTLEGGLKPAE*" gene 2752199..2752414 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" S_feature complement(2752396..2753808) /Source="Nicolas_S_feature" /locus_tag="new_2931889_2933301_c" /HighExp="S6, S8, S7, BT, S5, C30, B36, S4, B60, C90" /AntisenseName="ysfB" /AntisenseCor="0.46970634471519201" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1083" promotor_-35 2752425..2752432 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2752448..2752467 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2752456 /Source="Nicolas_upshifts" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" CDS 2752483..2753589 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (glycolate degradation operon)" /protein_id="NP_390745.2" /db_xref="EnsemblGenomes-Gn:BSU28670" /db_xref="EnsemblGenomes-Tr:CAB14827" /db_xref="InterPro:IPR008599" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12319" /db_xref="UniProtKB/Swiss-Prot:P94536" /translation="MFLQPLLAKKIIAEVKKMYEREVIIVNTDGLIMAGTNDERVGQF HEGALICAKERRSVIITKEDETRLKGVKAGINLPVFFDHDVIAVFGLTGEPAEIQPFG ELLRKMTELFIKESRHLEQSQWRERMLESFMIDWLQLKEWSPSFLEKAQLLGVDLSSR RQMILIQGYEWSPHDIEQMARSWKSSYPADLFIRWGNERILINHEVPQHEQRDRLLRK ILHICSFANTASSQYTAAGAGRAVASSSLTDSYEQAEKALAVSLKRKTPIFEEDLKLD MCLTEISPGTRNEFPQRVLGKALEHQELMNTIRTFFHHDLSLKQTAEDMHIHINTLRY RLAKAEQLTGLRFDRTEDVVTMYVALYFLDQDTK*" gene 2752483..2753589 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" promotor_-35 2753625..2753628 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2753644..2753663 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2753648 /Source="Nicolas_upshifts" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" CDS 2753692..2755104 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase subunit" /protein_id="NP_390746.1" /db_xref="EnsemblGenomes-Gn:BSU28680" /db_xref="EnsemblGenomes-Tr:CAB14828" /db_xref="GOA:P94535" /db_xref="InterPro:IPR004113" /db_xref="InterPro:IPR004490" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR016171" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12320" /db_xref="UniProtKB/Swiss-Prot:P94535" /translation="MITKDVKEQLIQVSGPENFDDSNAGRLVYSYDATPQYQSMPDAV IAPRNTDEISRILTICSEHRVPIVPRGSGTNLCGGTCPTEGGLVLLFKHMNQILEIDE ENLTATVQPGVITLDMIRAVESKGLFYPPDPSSMKISTIGGNINENSGGLRGLKYGVT RDYVIGLEVVLANGDIIRTGGKLAKDVAGYDLTRLFVGSEGTLGIVTEAIVKLVPKPE TKKTLLALYENIDAAAQTVSDIIAAKIIPATLEFLDQPTLLVIEDYAKIGLPTSAKAV LLIEQDGPFETVERDMEKIEAICKKGDAVSVQTAQTEEEAFALTEARRSALSALARLK PTTILEDATVPRSEIANMVKAINDIAAKYDISICTFGHAGDGNLHPTCTTDIRNKDEM ERVEQAFAEIFEKAIELGGTITGEHGVGEMKAPYLEMKLKKEGIDAMKALKAAFDPRN ILNPGKMFAKDARKRVVAER*" gene 2753692..2755104 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" promotor_-10 complement(2753794..2753813) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2753808) /Source="Nicolas_upshifts" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" promotor_-35 complement(2753826..2753835) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2755101..2756435 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase (iron-sulfur subunit)" /protein_id="NP_390747.1" /db_xref="EnsemblGenomes-Gn:BSU28690" /db_xref="EnsemblGenomes-Tr:CAB14829" /db_xref="GOA:P94534" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012257" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="SubtiList:BG12321" /db_xref="UniProtKB/Swiss-Prot:P94534" /translation="MTTEKEMKQIQNEFKERMDEGELLNCMRCGFCLPSCPTYIESGF QETHSPRGRIALMKAVADGMIEPDEDVERSLSLCLGCRACEPVCPSGVKYGQLLEEAR DIIHQNKKHSLGERVMRKTAFHELFPHQNRMRSAVSLIGLYQRSGLQTAVRKSGMLRV LPEHLRTMEAVLPDVPKSKDMKHRPRFLPSIGPMKKRVAFFSGCLMDTMFLPTNNATL KLLQLAGCDIVIPPEQACCGALHGHSGEKNTGKELAKQNIAAFEALDVDAVITNAGGC GAFLTEYDHLLKDDPEWSERAAAFVQKLKDFSSVLVELDFHQMDLALETPQVVTYQDS CHLRNVMHTSLEPRQLLKSIKGAEFKEMEKADSCCGSAGIYNIVEVEMSMKILDSKMA AVKATEAILIVTANPGCLLQMKLGIEREGLSGKVRAVHLADLLLEAAGHKTS*" gene 2755101..2756435 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" downshifts 2756433 /Source="Nicolas_upshifts" /id="D1468" /incds=0 /nref=48 /ntot=148 /MaxReadThrough="3.07756" /MaxDrop="5.25031" /score="4.55188138" /energy="-14.3" /TU="U2220" /idTUdmin="U2220" /TUdmin="-181" /isTUend="FALSE" downshifts complement(2756472) /Source="Nicolas_upshifts" /id="D1469" /incds=0 /nref=27 /ntot=221 /MaxReadThrough="1.51397" /MaxDrop="5.34865" /score="-5.71907967" /energy="-14.3" /TU="NA" /idTUdmin="U2222" /TUdmin="-2" /isTUend="TRUE" CDS complement(2756474..2756716) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390748.1" /db_xref="EnsemblGenomes-Gn:BSU28700" /db_xref="EnsemblGenomes-Tr:CAB14830" /db_xref="InterPro:IPR025870" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12322" /db_xref="UniProtKB/Swiss-Prot:P94533" /translation="MALNTRESARDITALDIPDTSASNTFEIGFVTENVEAVIKRMRE QGVSIIGEPKVKPWGQTVAYIADPDGHYIEICSPME*" gene complement(2756474..2756716) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" S_feature complement(2756717..2756888) /Source="Nicolas_S_feature" /locus_tag="new_2936210_2936381_c" /HighExp="Sw, M0t90, M40t90, M9-stat, T2.0H, BC, T0.30H, Lbstat, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1084" CDS complement(2756776..2756946) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513996.1" /translation="MGADVERSELKDGSIYTGLEGLLKMLRGVGNESINEISYSIRIG QQAGYSFFTGIF*" gene complement(2756776..2756946) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" CDS complement(2756889..2758685) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 1848300, 17320232, 19682248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 1848300, 17320232, 19682248; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="carbon starvation-induced membrane protein" /protein_id="NP_390749.2" /db_xref="EnsemblGenomes-Gn:BSU28710" /db_xref="EnsemblGenomes-Tr:CAB14831" /db_xref="GOA:P94532" /db_xref="InterPro:IPR003706" /db_xref="InterPro:IPR025299" /db_xref="SubtiList:BG11924" /db_xref="UniProtKB/Swiss-Prot:P94532" /translation="MNAVTIVIASMCILAIAYRLYGTFMMVKVLKVNDDKPTPAHALE DGKDYVPTNKWVSFGHHFAAIAAAGPLVGPILAAQFGYLPGLLWLLIGAVIGGAVHDI VVLFASMRKNGKSLSEVAKDELGPVAGFCTGLSMLFIITITMAGLSMVVLHALERNPW GTFAVGITIPIAMGVGLFYKKTGNLKLASTVGFLFLMAGVFIGPWVQTTALGDFLTLD TKTLAIALPVYAFFAAALPVWLLLAPRDYLSSFMKIGVFIALIVGVFVVNPSIPFPAF TEFVKGGGPVLAGPVWPFISITIACGAISGFHAFVGSGTTPKMLNKWSDMKPVAFGAM LVECLVGIMALIAATALQPADYFAINSTPEVFRTLGMNVVHLPELSGEIGLDLEGRTG GAVTLAVGMTYIFTGMPFFSHLASYFFQFVIMFEAVFILTAIDAGTRVARYLIQDFFG EVYKPLKKTDWIPGSVFASALACLMWGYLLYSGDIGSIWALFGVSNQLMASVGLIIGA TIVLKIADKRRYILTCLIPLAYLYVTVNYAGYWMVRNVYLNPEAAGYSVLNGVLSIIM LVLGFIIIVAAVKKWAQMWKDPSLRMEASIPG*" gene complement(2756889..2758685) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" promotor_-10 complement(2756991..2757009) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2757009) /Source="Nicolas_upshifts" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" promotor_-35 complement(2757021..2757029) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2758682 /Source="Nicolas_upshifts" /id="D1470" /incds=0 /nref=4 /ntot=49 /MaxReadThrough="0.92122" /MaxDrop="3.18629" /score="12.2066828" /energy="-15.2" /TU="NA" /idTUdmin="U2220" /TUdmin=2068 /isTUend="FALSE" promotor_-10 complement(2758710..2758729) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2758720) /Source="Nicolas_upshifts" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" promotor_-35 complement(2758744..2758750) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2758780..2758836) /Source="Nicolas_S_feature" /locus_tag="new_2938273_2938329_c" /HighExp="BC, Sw, M40t90, T1.30H, M0t90, T1.0H, T0.30H, Lbstat, T2.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1085" downshifts complement(2758804) /Source="Nicolas_upshifts" /id="D1471" /incds=0 /nref=12 /ntot=40 /MaxReadThrough="0.655710000000001" /MaxDrop="5.03461" /score="9.68754272" /energy="-10.5" /TU="NA" /idTUdmin="U2224" /TUdmin="-2" /isTUend="TRUE" CDS complement(2758837..2760339) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12777810, 14973026, 16233670, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12777810, 14973026, 16233670, 18757805; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-L-arabinofuranosidase" /protein_id="NP_390750.2" /db_xref="EnsemblGenomes-Gn:BSU28720" /db_xref="EnsemblGenomes-Tr:CAB14832" /db_xref="GOA:P94531" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11900" /db_xref="UniProtKB/Swiss-Prot:P94531" /translation="MKKARMIVDKEYKIGEVDKRIYGSFIEHMGRAVYEGIYEPDHPE ADEDGFRKDVQSLIKELQVPIIRYPGGNFLSGYNWEDGVGPVENRPRRLDLAWQTTET NEVGTNEFLSWAKKVNTEVNMAVNLGTRGIDAARNLVEYCNHPKGSYWSDLRRSHGYE QPYGIKTWCLGNEMDGPWQIGHKTADEYGRLAAETAKVMKWVDPSIELVACGSSNSGM PTFIDWEAKVLEHTYEHVDYISLHTYYGNRDNNLPNYLARSMDLDHFIKSVAATCDYV KAKTRSKKTINLSLDEWNVWYHSNEADKKVEPWITARPILEDIYNFEDALLVGSLLIT MLQHADRVKIACLAQLVNVIAPIMTEKGGEAWRQPIFYPYMHASVYGRGESLKPLISS PKYDCSDFTDVPYVDAAVVYSEEEETLTIFAVNKAEDQMETEISLRGFESYQIAEHIV LEHQDIKATNQHNRKNVVPHSNGSSSVSENGLTAHFTPLSWNVIRLKKQS*" gene complement(2758837..2760339) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" downshifts complement(2760210) /Source="Nicolas_upshifts" /id="D1472" /incds=1 /nref=7 /ntot=15 /MaxReadThrough="3.81491" /MaxDrop="6.33773" /score="2.73497974" /energy="-14.2" /TU="U2224,U2225" /idTUdmin="U2224" /TUdmin="-1408" /isTUend="FALSE" promotor_no_box complement(2760314..2760414) /Source="Nicolas_upshift_promotors" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2760354) /Source="Nicolas_upshifts" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" CDS complement(2760358..2761203) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390751.2" /db_xref="EnsemblGenomes-Gn:BSU28730" /db_xref="EnsemblGenomes-Tr:CAB14833" /db_xref="GOA:P94530" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11912" /db_xref="UniProtKB/Swiss-Prot:P94530" /translation="MLRHSPQFSVYRIALTLFFMMLSLLYLFPIFCLLLGSLKPSSEL LRVGLNLDIDPKVMSFDNYTFLFNGGSIYFKWFFNSLVLGLFTTVLTLFFSSMIGYGL AVYDFKGRNIIFVLVLIIMMVPLEVMMLPLFKLTVGLHLIDSYTGVILPFIVSPVAVF FFRQYALGLPRDLLDSARMDGCTEFGIFFRIMAPLMKPAFGAMIILQSLNSWNNFLWP LIVLRSKEMFTLPIGLSSLLSPYGNNYDMLISGSVFAILPVIIIFLFFQKYFISGLTV GGVKG*" gene complement(2760358..2761203) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" CDS complement(2761204..2762145) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390752.1" /db_xref="EnsemblGenomes-Gn:BSU28740" /db_xref="EnsemblGenomes-Tr:CAB14834" /db_xref="GOA:P94529" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11911" /db_xref="UniProtKB/Swiss-Prot:P94529" /translation="MKPVKTGTVHPVPSAAKQSGWRDLFYSKKAAPYLFTAPFVLSFL VFFLYPIISVFIMSFQRILPGEVSFVGLSNYTALNNPTFYTALWNTLEYTFWTLIVLI PVPLLLAIFLNSKLVKFRNIFKSALFIPALTSTIVAGIIFRLIFGEMETSLANSILLK LGFSPQNWMNNEHTGMFLMVLLASWRWMGINILYFLAGLQNVPKELYEAADIDGANTM KKFLHITLPFLKPVTVYVLTISIIGGFRMFEESYVLWQNNSPGNIGLTLVGYLYQQGL AYNEMGYGAAIGIVLLIVILVVSLISLKLSGSFKGEG*" gene complement(2761204..2762145) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" CDS complement(2762181..2763482) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="sugar-binding lipoprotein" /protein_id="NP_390753.2" /db_xref="EnsemblGenomes-Gn:BSU28750" /db_xref="EnsemblGenomes-Tr:CAB14835" /db_xref="GOA:P94528" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG11910" /db_xref="UniProtKB/Swiss-Prot:P94528" /translation="MKKMTVCFLVLMMLLTLVIAGCSAEKSSGKSGETELTFWTFNGL HEQFYVEMVKEWNKKYPDRKIKLNTVVYPYGQMHDNLSISLIAGEGVPDIADVELARF SNFLKGSDIPLADLTPLIEKDRDKFVEARLTLYSKNGKLYGLDTHVGTTVMFYNMDVM KKAGVNPDDIKTWDDYHKAGQKVRKVTGKPMGTVETNDSATFLSMISQQNSGYFDKNG KLILNNDTNVKTLQYLKDMINDKTMIPAPGGGHHSEEYYGFMNQGGAASVLMPIWYMG RFIDYMPDLKGKIAIRPLPAWKEGGDRSAGLGGTATVVPKQSKHVELAKEFLAFAKGS EEGNKKLWSVLGFDPLRWDVWSSKELKEKNKYTDYFQNGTGIFSVLLDIKDEINPIYL HEDFAKASDLVNRSVLFDALKSQQKTPKQALDRAAGELKQK*" gene complement(2762181..2763482) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" CDS complement(2763513..2764697) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" /EC_number="1.1.1.261" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-1-phosphate dehydrogenase [NAD+] (catabolic)" /protein_id="NP_390754.1" /db_xref="EnsemblGenomes-Gn:BSU28760" /db_xref="EnsemblGenomes-Tr:CAB14836" /db_xref="GOA:P94527" /db_xref="InterPro:IPR023003" /db_xref="InterPro:IPR032837" /db_xref="SubtiList:BG11909" /db_xref="UniProtKB/Swiss-Prot:P94527" /translation="MNRIAADVQRAFENAGEKTLPIKVEEIVLGKQAADSLLDYVKRK NNQHIVLVCDANTHRIAGIDLENRLNQEGFQAECLIIPENEAGDVTADERSLIHVLIH TKQPTDVMIAVGSGTIHDIVRFAAFQRDLPFISYPTAPSVDGFTSAGAPIILYGTKTT IQTKAPSALFADLDLLKAAPQSMVAAGFGDMLGKITSLADWEISRHLAGEPYSPAGAK IVQEALAACIEHTEDIAMKTETGIRVLMESLLVSGLVMLALDHSRPASGGEHHISHWI EMELMEKKRPQILHGAKVGCAAVLLTDTYRKLAQDDGLNEFSPSRREAIQSAYQTLPR GEVLADWLRSAGGPAYFDEIGVGQDSVKNAFRHAHTLRDRCTGLRIINENKTLINHGL YE*" gene complement(2763513..2764697) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" CDS complement(2764694..2765512) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" /EC_number="3.1.3.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 14973026, 21575135, 22720735, 25848029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 14973026, 21575135, 22720735, 25848029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycolytic and pentose phosphate intermediates phosphatase" /protein_id="NP_390755.1" /db_xref="EnsemblGenomes-Gn:BSU28770" /db_xref="EnsemblGenomes-Tr:CAB14837" /db_xref="GOA:P94526" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11908" /db_xref="UniProtKB/Swiss-Prot:P94526" /translation="MRIMASHDTPVSPAGILIDLDGTVFRGNELIEGAREAIKTLRRM GKKIVFLSNRGNISRAMCRKKLLGAGIETDVNDIVLSSSVTAAFLKKHYRFSKVWVLG EQGLVDELRLAGVQNASEPKEADWLVISLHETLTYDDLNQAFQAAAGGARIIATNKDR SFPNEDGNAIDVAGMIGAIETSAQAKTELVVGKPSWLMAEAACTAMGLSAHECMIIGD SIESDIAMGKLYGMKSALVLTGSAKQGEQRLYTPDYVLDSIKDVTKLAEEGILI*" gene complement(2764694..2765512) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" CDS complement(2765490..2766179) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" /EC_number="5.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10417639, 11418559, 11732895, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulose-5-phosphate 4-epimerase" /protein_id="NP_390756.1" /db_xref="EnsemblGenomes-Gn:BSU28780" /db_xref="EnsemblGenomes-Tr:CAB14838" /db_xref="GOA:P94525" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR004661" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG11906" /db_xref="UniProtKB/Swiss-Prot:P94525" /translation="MLETLKKEVLAANLKLQEHQLVTFTWGNVSGIDREKERIVIKPS GVEYSDLTADDLVVLNLDGEVVEGSLKPSSDTPTHVYLYKAFPNIGGIVHTHSQWATS WAQSGRDIPPLGTTHADYFDSAIPCTREMYDEEIIHDYELNTGKVIAETFQHHNYEQV PGVLVNNHGPFCWGTDALNAIHNAVVLETVAEMAYHSIMLNKDVTPINTVLHEKHFYR KHGANAYYGQS*" gene complement(2765490..2766179) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" CDS complement(2766196..2767878) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" /EC_number="2.7.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 173711, 4910050, 10417639, 11418559, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulokinase" /protein_id="NP_390757.1" /db_xref="EnsemblGenomes-Gn:BSU28790" /db_xref="EnsemblGenomes-Tr:CAB14839" /db_xref="GOA:P94524" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005929" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG11905" /db_xref="UniProtKB/Swiss-Prot:P94524" /translation="MAYTIGVDFGTLSGRAVLVHVQTGEELAAAVKEYRHAVIDTVLP KTGQKLPRDWALQHPADYLEVLETTIPSLLEQTGVDPKDIIGIGIDFTACTILPIDSS GQPLCMLPEYEEEPHSYVKLWKHHAAQKHADRLNQIAEEEGEAFLQRYGGKISSEWMI PKVMQIAEEAPHIYEAADRIIEAADWIVYQLCGSLKRSNCTAGYKAMWSEKAGYPSDD FFEKLNPSMKTITKDKLSGSIHSVGEKAGSLTEKMAKLTGLLPGTAVAVANVDAHVSV PAVGITEPGKMLMIMGTSTCHVLLGEEVHIVPGMCGVVDNGILPGYAGYEAGQSCVGD HFDWFVKTCVPPAYQEEAKEKNIGVHELLSEKANHQAPGESGLLALDWWNGNRSTLVD ADLTGMLLGMTLLTKPEEIYRALVEATAYGTRMIIETFKESGVPIEELFAAGGIAEKN PFVMQIYADVTNMDIKISGSPQAPALGSAIFGALAAGKEKGGYDDIKKAAANMGKLKD ITYTPNAENAAVYEKLYAEYKELVHYFGKENHVMKRLKTIKNLQFSSAAKKN*" gene complement(2766196..2767878) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" CDS complement(2767892..2769382) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" /EC_number="5.3.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 10669396, 11418559, 14973026, 18263741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 10669396, 11418559, 14973026, 18263741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-arabinose isomerase" /protein_id="NP_390758.2" /db_xref="EnsemblGenomes-Gn:BSU28800" /db_xref="EnsemblGenomes-Tr:CAB14840" /db_xref="GOA:P94523" /db_xref="InterPro:IPR003762" /db_xref="InterPro:IPR004216" /db_xref="InterPro:IPR009015" /db_xref="InterPro:IPR024664" /db_xref="SubtiList:BG11904" /db_xref="UniProtKB/Swiss-Prot:P94523" /translation="MLQTKDYEFWFVTGSQHLYGEETLELVDQHAKSICEGLSGISSR YKITHKPVVTSPETIRELLREAEYSETCAGIITWMHTFSPAKMWIEGLSSYQKPLMHL HTQYNRDIPWGTIDMDFMNSNQSAHGDREYGYINSRMGLSRKVIAGYWDDEEVKKEMS QWMDTAAALNESRHIKVARFGDNMRHVAVTDGDKVGAHIQFGWQVDGYGIGDLVEVMD RITDDEVDTLYAEYDRLYVISEETKRDEAKVASIKEQAKIELGLTAFLEQGGYTAFTT SFEVLHGMKQLPGLAVQRLMEKGYGFAGEGDWKTAALVRMMKIMAKGKRTSFMEDYTY HFEPGNEMILGSHMLEVCPTVALDQPKIEVHSLSIGGKEDPARLVFNGISGSAIQASI VDIGGRFRLVLNEVNGQEIEKDMPNLPVARVLWKPEPSLKTAAEAWILAGGAHHTCLS YELTAEQMLDWAEMAGIESVLISRDTTIHKLKHELKWNEALYRLQK*" gene complement(2767892..2769382) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" promotor_-10 complement(2769475..2769494) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2769482) /Source="Nicolas_upshifts" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" S_feature complement(2769484..2769559) /Source="Nicolas_S_feature" /locus_tag="new_2948977_2949052_c" /HighExp="M9-stat, T1.30H, T2.0H, T2.30H, T3.0H, T4.0H, T3.30H, T1.0H, BC, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1086" promotor_-35 complement(2769509..2769516) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2769560..2770531) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 15556708, 17827291, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 15556708, 17827291, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan-endo-1,5-alpha-L-arabinase" /protein_id="NP_390759.2" /db_xref="EnsemblGenomes-Gn:BSU28810" /db_xref="EnsemblGenomes-Tr:CAB14841" /db_xref="GOA:P94522" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR016840" /db_xref="InterPro:IPR023296" /db_xref="PDB:1UV4" /db_xref="SubtiList:BG11901" /db_xref="UniProtKB/Swiss-Prot:P94522" /translation="MKKKKTWKRFLHFSSAALAAGLIFTSAAPAEAAFWGASNELLHD PTMIKEGSSWYALGTGLTEERGLRVLKSSDAKNWTVQKSIFTTPLSWWSNYVPNYGQN QWAPDIQYYNGKYWLYYSVSSFGSNTSAIGLASSTSISSGGWKDEGLVIRSTSSNNYN AIDPELTFDKDGNPWLAFGSFWSGIKLTKLDKSTMKPTGSLYSIAARPNNGGALEAPT LTYQNGYYYLMVSFDKCCDGVNSTYKIAYGRSKSITGPYLDKSGKSMLEGGGTILDSG NDQWKGPGGQDIVNGNILVRHAYDANDNGIPKLLINDLNWSSGWPSY*" gene complement(2769560..2770531) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" S_feature complement(2770532..2770660) /Source="Nicolas_S_feature" /locus_tag="new_2950025_2950153_c" /HighExp="M9-stat, BC, T2.0H, T2.30H, T3.0H, S8, T1.30H, T3.30H, M0t90, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1087" promotor_-10 complement(2770645..2770664) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-10" upshifts complement(2770660) /Source="Nicolas_upshifts" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" promotor_-35 complement(2770679..2770682) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-35" CDS complement(2770728..2771813) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15375159, 16021622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fructose-lysine aminopeptidase" /protein_id="NP_390760.1" /db_xref="EnsemblGenomes-Gn:BSU28820" /db_xref="EnsemblGenomes-Tr:CAB14842" /db_xref="GOA:P94521" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="PDB:1VHE" /db_xref="SubtiList:BG12317" /db_xref="UniProtKB/Swiss-Prot:P94521" /translation="MAKLDETLTMLKDLTDAKGIPGNEREVRQVMKSYIEPFADEVTT DRLGSLIAKKTGAENGPKIMIAGHLDEVGFMVTQITDKGFIRFQTVGGWWAQVMLAQR VTIVTKKGEITGVIGSKPPHILSPEARKKSVEIKDMFIDIGASSREEALEWGVLPGDM IVPHFEFTVMNNEKFLLAKAWDNRIGCAIAIDVLRNLQNTDHPNIVYGVGTVQEEVGL RGAKTAAHTIQPDIAFGVDVGIAGDTPGISEKEAQSKMGKGPQIIVYDASMVSHKGLR DAVVATAEEAGIPYQFDAIAGGGTDSGAIHLTANGVPALSITIATRYIHTHAAMLHRD DYENAVKLITEVIKKLDRKTVDEITYQ*" gene complement(2770728..2771813) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" downshifts complement(2770742) /Source="Nicolas_upshifts" /id="D1473" /incds=0 /nref=233 /ntot=262 /MaxReadThrough="3.55686" /MaxDrop="6.91328" /score="-0.475558157" /energy="-9.9" /TU="U2227" /idTUdmin="U2227" /TUdmin="-66" /isTUend="FALSE" promotor_-10 complement(2771839..2771858) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-10" upshifts complement(2771862) /Source="Nicolas_upshifts" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" promotor_-35 complement(2771873..2771880) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-35" promotor_-35 2771931..2771940 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2771946 /Source="Nicolas_upshifts" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" promotor_-10 2771952..2771967 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2771997..2772389 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10960106, 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390761.1" /db_xref="EnsemblGenomes-Gn:BSU28830" /db_xref="EnsemblGenomes-Tr:CAB14843" /db_xref="GOA:P94520" /db_xref="SubtiList:BG12316" /db_xref="UniProtKB/Swiss-Prot:P94520" /translation="MFVMVLRIILLALFAYCIYAVVKYVANPKRRLKLAQSKEHFYII DEQNNTRKNFQLTYKGVLFEGEKHIPSKDHPLFIHTIFVWTESPEKLKHFSAKDFENI EEKVLERYPNCKIDWDQPIKLAKKAEER*" gene 2771997..2772389 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" downshifts 2772360 /Source="Nicolas_upshifts" /id="D1474" /incds=0 /nref=86 /ntot=229 /MaxReadThrough="5.09744" /MaxDrop="4.57118" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-2112" /isTUend="FALSE" S_feature 2772405..2772711 /Source="Nicolas_S_feature" /locus_tag="new_2951898_2952204" /HighExp="Etha, M9-stat, T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, S8, T3.30H, Salt" /AntisenseName="ysdA" /AntisenseCor="-0.31305612685159701" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1088" CDS complement(2772405..2772674) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17289755; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_390762.1" /db_xref="EnsemblGenomes-Gn:BSU28840" /db_xref="EnsemblGenomes-Tr:CAB14844" /db_xref="GOA:P94519" /db_xref="InterPro:IPR010718" /db_xref="SubtiList:BG12315" /db_xref="UniProtKB/Swiss-Prot:P94519" /translation="MIIAAYLVLINLCGFWVMGIDKRKAQQHKWRISEDRLWLIAIVF GALGVWLGMQTFRHKTKHASFKYGVPLLLVIEAILIAIYYSPFDL*" gene complement(2772405..2772674) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" downshifts complement(2772421) /Source="Nicolas_upshifts" /id="D1475" /incds=0 /nref=6 /ntot=206 /MaxReadThrough="2.53274" /MaxDrop="3.80421" /score="20.1281719" /energy="-14" /TU="U2229" /idTUdmin="U2230" /TUdmin="-7" /isTUend="TRUE" downshifts complement(2772590) /Source="Nicolas_upshifts" /id="D1476" /incds=1 /nref=1 /ntot=37 /MaxReadThrough="4.90568" /MaxDrop="2.19601" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-176" /isTUend="FALSE" downshifts 2772668 /Source="Nicolas_upshifts" /id="D1477" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="4.08794" /MaxDrop="3.37039" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-1804" /isTUend="FALSE" CDS complement(2772731..2773090) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L20" /protein_id="NP_390763.1" /db_xref="EnsemblGenomes-Gn:BSU28850" /db_xref="EnsemblGenomes-Tr:CAB14845" /db_xref="GOA:P55873" /db_xref="InterPro:IPR005813" /db_xref="InterPro:IPR035566" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11971" /db_xref="UniProtKB/Swiss-Prot:P55873" /translation="MPRVKGGTVTRKRRKKVLKLAKGYFGSKHTLYKVANQQVMKSGN YAFRDRRQKKRDFRKLWITRINAAARMNGLSYSRLMHGLKLSGIEVNRKMLADLAVND LTAFNQLADAAKAQLNK*" gene complement(2772731..2773090) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" downshifts complement(2772744) /Source="Nicolas_upshifts" /id="D1478" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="5.94351" /MaxDrop="6.27682" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-330" /isTUend="FALSE" CDS complement(2773122..2773322) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L35" /protein_id="NP_390764.1" /db_xref="EnsemblGenomes-Gn:BSU28860" /db_xref="EnsemblGenomes-Tr:CAB14846" /db_xref="GOA:P55874" /db_xref="InterPro:IPR001706" /db_xref="InterPro:IPR018265" /db_xref="InterPro:IPR021137" /db_xref="InterPro:IPR037229" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11972" /db_xref="UniProtKB/Swiss-Prot:P55874" /translation="MPKMKTHRGSAKRFKKTGSGKLKRSHAYTSHLFANKSQKQKRKL RKSAVVSAGDFKRIKQMLANIK*" gene complement(2773122..2773322) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" CDS complement(2773335..2773856) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-3" /protein_id="NP_390765.1" /db_xref="EnsemblGenomes-Gn:BSU28870" /db_xref="EnsemblGenomes-Tr:CAB14847" /db_xref="GOA:P55872" /db_xref="InterPro:IPR001288" /db_xref="InterPro:IPR019813" /db_xref="InterPro:IPR019814" /db_xref="InterPro:IPR019815" /db_xref="InterPro:IPR036787" /db_xref="InterPro:IPR036788" /db_xref="SubtiList:BG11944" /db_xref="UniProtKB/Swiss-Prot:P55872" /translation="MISKDQLVNEGIRAREVRLIGQNGDQLGIKSRQEALEIAGRANL DLVLVAANAKPPVCRIMDYGKFRFEQQKKEKEARKNQKIINLKEVRLSPTIDEHDFNT KLRNAIKFLEKGDKVKASIRFKGRAITHKEIGQRVLDRFSEACAEVATVETKPKMDGR SMFLMLAPKNEKQ*" gene complement(2773335..2773856) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" misc_RNA complement(2773918..2774057) /locus_tag="BSU_misc_RNA_47" /product="mRNA L20_leader attenuator sequence" /experiment="publication(s) with functional evidences, PMID:17289755, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17289755, 23611891" gene complement(2773918..2774057) /locus_tag="BSU_misc_RNA_47" promotor_-10 complement(2774054..2774073) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2774064) /Source="Nicolas_upshifts" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" S_feature complement(2774066..2774130) /Source="Nicolas_S_feature" /locus_tag="new_2953559_2953623_c" /HighExp="Paraq, G180, G150, G135, H2O2, LPh, C30, Oxctl, LBGexp, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1089" promotor_-35 complement(2774087..2774094) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2774112..2774131) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2774130) /Source="Nicolas_upshifts" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" promotor_-35 complement(2774147..2774151) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2774249..2774256 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2774270..2774288 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2774270 /Source="Nicolas_upshifts" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" CDS 2774302..2774967 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" /function="14: Cell envelope" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390767.2" /db_xref="EnsemblGenomes-Gn:BSU28890" /db_xref="EnsemblGenomes-Tr:CAB14849" /db_xref="SubtiList:BG12314" /db_xref="UniProtKB/Swiss-Prot:P94517" /translation="MNKLIQLALFFTLMLTGCSNSSTSSESKVETTVKTTAAFPQKEL EKELKKLKPVSLDMKFESPLATELGKRKAKEEAEKQRQIAAEKKLEKEREAKRKKQQE EKAERQRLAEQQAAERQRLAEAERQAELERQRQAAIQKEQKANAEKKRQSQAQRQQTE APSSNSQDPPSSSSQTDKTIQQPASELPDDDGYGYEERKKWHDDQVEWGIKQGYIDPE DAP*" gene 2774302..2774967 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" downshifts 2774945 /Source="Nicolas_upshifts" /id="D1479" /incds=0 /nref=27 /ntot=178 /MaxReadThrough="2.51181" /MaxDrop="3.43861" /score="13.4996084" /energy="-15.8" /TU="NA" /idTUdmin="U2231" /TUdmin=0 /isTUend="TRUE" CDS complement(2774999..2775694) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" /function="16.5: Explore" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pyruvate import system subunit B" /protein_id="NP_390768.1" /db_xref="EnsemblGenomes-Gn:BSU28900" /db_xref="EnsemblGenomes-Tr:CAB14850" /db_xref="GOA:P94516" /db_xref="InterPro:IPR007300" /db_xref="InterPro:IPR024891" /db_xref="SubtiList:BG12312" /db_xref="UniProtKB/Swiss-Prot:P94516" /translation="MESTMSPYFGIVVSLAAFGIGTFLFKKTKGFFLFTPLFVAMVLG IAFLKIGGFSYADYNNGGEIIKFFLEPATIAFAIPLYKQRDKLKKYWWQIMASIIAGS ICSVTIVYLLAKGIHLDSAVMKSMLPQAATTAIALPLSKGIGGISDITAFAVIFNAVI VYALGALFLKVFKVKNPISKGLALGTSGHALGVAVGIEMGEVEAAMASIAVVVVGVVT VLVIPVFVQLIGG*" gene complement(2774999..2775694) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" downshifts complement(2775021) /Source="Nicolas_upshifts" /id="D1480" /incds=0 /nref=19 /ntot=45 /MaxReadThrough="1.25312" /MaxDrop="6.13174" /score="49.3872074" /energy="-13.7" /TU="NA" /idTUdmin="U2232" /TUdmin=0 /isTUend="TRUE" downshifts complement(2775065) /Source="Nicolas_upshifts" /id="D1481" /incds=1 /nref=2 /ntot=36 /MaxReadThrough="6.79502" /MaxDrop="3.1016" /score="49.3872074" /energy="-13.7" /TU="U2232" /idTUdmin="U2232" /TUdmin="-44" /isTUend="FALSE" CDS complement(2775716..2776156) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15659658, 17452642, 26060272, 27422364, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15659658, 17452642, 26060272, 27422364, 28974613; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyruvate uptake system subunit A" /protein_id="NP_390769.1" /db_xref="EnsemblGenomes-Gn:BSU28910" /db_xref="EnsemblGenomes-Tr:CAB14851" /db_xref="GOA:P94515" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023736" /db_xref="SubtiList:BG12311" /db_xref="UniProtKB/Swiss-Prot:P94515" /translation="MSAKKVYGFLTQAFIFAVIMLVSNMIAAIVPIPIPASVVGLVLL FLLLCLKVIKLEQVETLGTSLTSLIGFLFVPSGISVMNSLGVMQQYGLQIVLVILLAT IILLGATGLFSQLILSLSGKRKTEADMKTKTVQSPQNNNELVHH*" gene complement(2775716..2776156) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" promotor_-10 complement(2776178..2776197) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2776197) /Source="Nicolas_upshifts" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" promotor_-35 complement(2776213..2776216) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2776290..2777015) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LytS]" /protein_id="NP_390770.1" /db_xref="EnsemblGenomes-Gn:BSU28920" /db_xref="EnsemblGenomes-Tr:CAB14852" /db_xref="GOA:P94514" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11953" /db_xref="UniProtKB/Swiss-Prot:P94514" /translation="MLRVLIVDDEMLARDELAYLLKRTNDEMEINEAENIESAFDQMM DQKPDLLFLDVDLSGENGFDIAKRLKKMKHPPAIVFATAYDQYALKAFEVDALDYLTK PFDEERIQQTLKKYKKVNRDIVETEQNSHAGQHKLALSVGESIVIVDTKDIIYAGTED GHVNVKTFDHSYTVSDTLVVIEKKLPDSDFIRVHRSFVVNTEYIKEIQPWFNSTYNLI MKDGSKIPVSRTYAKELKKLLHI*" gene complement(2776290..2777015) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" downshifts complement(2776319) /Source="Nicolas_upshifts" /id="D1482" /incds=0 /nref=231 /ntot=256 /MaxReadThrough="-0.0173499999999995" /MaxDrop="6.64673" /score="-8.47161605" /energy="-8.9" /TU="NA" /idTUdmin="U2232" /TUdmin="-1298" /isTUend="FALSE" CDS complement(2776993..2778774) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" /function="16.3: Control" /function="16.13: Shape" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LytT]" /protein_id="NP_390771.1" /db_xref="EnsemblGenomes-Gn:BSU28930" /db_xref="EnsemblGenomes-Tr:CAB14853" /db_xref="GOA:P94513" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11952" /db_xref="UniProtKB/Swiss-Prot:P94513" /translation="MIHLMIMMLERVGIIVILGFILAHTKLFRQALQNQDGYKGKAIL ISIFSLFSIISNYTGIEIQRNMIVNNDWVFTIDPSGSIANTRILGVEIGGLLGGPFVG AGIGILAGLHRFSLGGSTALSCAVSSILAGVLAGLIGRYFTKRYRMPTPRIAALVGIG MESLQMIIILLMAKPFSDAWELVSMIGIPMILINGTGSFIFLSIIQAIIRKEEQARAL ETHRVLTIADQTLPFFRQGLNENSCKSVAAIIHKLTGTDAVSLTDKEKILAHVGAGMD HHIPSKSLITGLSKKVIKTGHIMKAISQEEIECTHAECPLHAAIVLPLTSNGNTIGTL KMYFKSPAGLSQVEEELAEGLAMLFSTQLELGEAELQSKLLKDAEIKALQAQVNPHFL FNAINTISALCRTDVEKTRKLLLQLSVYFRSNLQGARQLLIPLSKELNHLNAYLSLEQ ARFPGKYKIELNIDSRLEQIEIPPFVLQVLVENALRHAFPKKQDICKVTVCVLSDDAS VYMKVADNGRGIPPDVLPELGKKPFPSKEGTGTALYNLNQRLIGLFGQQAALHISSEV HKGTEVSFQVPMQQMKEGEEHAQGVNS*" gene complement(2776993..2778774) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" promotor_-35 2778858..2778861 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2778870..2778889) /Source="Nicolas_upshift_promotors" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2778875) /Source="Nicolas_upshifts" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2778876..2778895 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2778883 /Source="Nicolas_upshifts" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" CDS 2778941..2779723 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:15479782, 24123841, 25848029, 27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15479782, 24123841, 25848029, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase" /protein_id="NP_390772.2" /db_xref="EnsemblGenomes-Gn:BSU28940" /db_xref="EnsemblGenomes-Tr:CAB14854" /db_xref="GOA:P94512" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12310" /db_xref="UniProtKB/Swiss-Prot:P94512" /translation="MKAVFFDLDDTLLWDEKSVRTTFAETCLQAEKKYGLAPEEFEAA VREAARELYMSYETYPYTVMIGINPFEGLWSNFSEPISEGFQKLNKIVPEYRRNAWTN GLKALGIDDPAYGEYLGEFFAAERRKRPFVYDETFAVLDQLKGKYELLLLTNGDPSLQ KEKLAGVPELAPYFNEIVISGAFGKGKPDVSIFEHCLKLMNIEKDDAIMVGDNLNTDI LGASRAGIKTVWINRTDKKNETDVKPDYIISSLHDLFPILEK*" gene 2778941..2779723 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" downshifts 2779707 /Source="Nicolas_upshifts" /id="D1483" /incds=0 /nref=36 /ntot=265 /MaxReadThrough="1.0046" /MaxDrop="6.73727" /score="35.9560361" /energy="-13.8" /TU="NA" /idTUdmin="U2234" /TUdmin="-12" /isTUend="TRUE" downshifts complement(2779757) /Source="Nicolas_upshifts" /id="D1484" /incds=0 /nref=89 /ntot=246 /MaxReadThrough="1.13716" /MaxDrop="6.01766" /score="35.534455" /energy="-13.8" /TU="NA" /idTUdmin="U2235" /TUdmin="-6" /isTUend="TRUE" CDS complement(2779764..2781695) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8692931, 9826762, 10632708, 15831787, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8692931, 9826762, 10632708, 15831787, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_390773.1" /db_xref="EnsemblGenomes-Gn:BSU28950" /db_xref="EnsemblGenomes-Tr:CAB14855" /db_xref="GOA:P18255" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10362" /db_xref="UniProtKB/Swiss-Prot:P18255" /translation="MSDMVKITFPDGAVKEFAKGTTTEDIAASISPGLKKKSLAGKLN GKEIDLRTPINEDGTVEIITEGSEEGLQIMRHSAAHLLAQAIKRIYKDVKFGVGPVIE NGFYYDVEMDEAITPEDLPKIEKEMKKIVNANLPIVRKEVSREEAKARFAEIGDDLKL ELLDAIPEGETVSIYEQGEFFDLCRGVHVPSTGKIKEFKLLSLAGAYWRGDSKNQMLQ RVYGTAFFKKADLEEHLRMLEEAKERDHRKLGKELKLFANSQKVGQGLPLWLPKGATI RRVIERYIVDKEISLGYEHVYTPVLGSKELYETSGHWDHYQEGMFPPMEMDNETLVLR PMNCPHHMMIYKQDIHSYRELPIRIAELGTMHRYEMSGALSGLQRVRGMTLNDAHIFV RPDQIKDEFIRTVRLIQDVYEDFGLSDYTFRLSYRDPEDTEKYFDDDEMWNKAQSMLK EAMDEIGHDYYEAEGEAAFYGPKLDVQVKTAIGKEETLSTVQLDFLLPERFDLTYIGE DGKQHRPVVIHRGVVSTMERFVAFLIEEHKGALPTWLAPVQFQVIPVSPAVHLDYAKK VQERLQCEGLRVEVDSRDEKIGYKIREAQMQKIPYMLVVGDQEAENGAVNVRKYGEQN SETISLDEFVKKAVAEAKK*" gene complement(2779764..2781695) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" misc_RNA complement(2781739..2781986) /gene="tboT" /locus_tag="BSU_misc_RNA_48" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:9098041, 9826762, 1317842, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 9826762, 1317842, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" gene complement(2781739..2781986) /gene="tboT" /locus_tag="BSU_misc_RNA_48" promotor_-10 complement(2781742..2781751) /Source="Nicolas_upshift_promotors" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2781742) /Source="Nicolas_upshifts" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" promotor_-35 complement(2781770) /Source="Nicolas_upshift_promotors" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2781797) /Source="Nicolas_upshifts" /id="D1485" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="6.71261" /MaxDrop="3.31801" /score="19.160794" /energy="-16.2" /TU="U2236,U2237,U2238,U2241" /idTUdmin="U2239" /TUdmin=221 /isTUend="FALSE" promotor_-10 complement(2781997..2782016) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2782010) /Source="Nicolas_upshifts" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" S_feature complement(2782012..2782092) /Source="Nicolas_S_feature" /locus_tag="new_2961505_2961585_c" /HighExp="S3, S4, LoTm, S5, G135, G180, LBGtran, T5.0H, G/S, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1090" promotor_-35 complement(2782032..2782036) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2782093..2782938) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22882546; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation protein" /protein_id="NP_390774.2" /db_xref="EnsemblGenomes-Gn:BSU28960" /db_xref="EnsemblGenomes-Tr:CAB14856" /db_xref="InterPro:IPR014199" /db_xref="SubtiList:BG10361" /db_xref="UniProtKB/Swiss-Prot:P06569" /translation="MLEIIFEDDHDAAAFLHLIQHSDDRNNIIVREGIRKIGIEKANP AFPIQRFMEPILVKFFLECKEDEHMLSLIEETYCFTDQDEQQQILQLAHSIIEGEADD LPFEPLKLSRKQSILDELQTICLEEGVFYIRSFQTFRLGSYYKQLRDITEAAIDEYKM EQEYQNFIQTLRDYVDAKQPRIKKVHIVHDGSFTLWELRYVPEREKMKYIDRRFVRDH PMYIDSHLLAPLISIAPDEVVLYTDQPEHMMARTIQNVFQERVEMLPLHAFTDAEIPV KHSEG*" gene complement(2782093..2782938) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" promotor_-10 complement(2782958..2782976) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2782964) /Source="Nicolas_upshifts" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" promotor_-35 complement(2782992..2782997) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2783017..2783658) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25728272, 27190159; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative osomosensing transporter" /protein_id="NP_390775.1" /db_xref="EnsemblGenomes-Gn:BSU28970" /db_xref="EnsemblGenomes-Tr:CAB14857" /db_xref="GOA:P06568" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG10360" /db_xref="UniProtKB/Swiss-Prot:P06568" /translation="MKRKTAVKWLAVLAGAGLLYWGNKTYLNVSPKEIRVWVLSFGVF APLMFIGISIVRPLVLFPVSVISIAGGLAFGPLLGTLYTLFGSMCASAVSFFAAGLFS AKKNGHYERLEAIQKQMEDNGFFYIFLLRILPINFDFVSYAAGLSNVKALPYFAATAV GIIPGTIALNVLGASFLAGNLPAFFMVLALYIVFISLPFIFRKKMQNLFQESN*" gene complement(2783017..2783658) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" CDS complement(2783692..2784627) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 17003052, 17289076, 19255093, 19968790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17003052, 17289076, 19255093, 19968790; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loader" /protein_id="NP_390776.1" /db_xref="EnsemblGenomes-Gn:BSU28980" /db_xref="EnsemblGenomes-Tr:CAB14858" /db_xref="GOA:P06567" /db_xref="InterPro:IPR002611" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009928" /db_xref="InterPro:IPR027417" /db_xref="PDB:2K7R" /db_xref="PDB:4M4W" /db_xref="SubtiList:BG10359" /db_xref="UniProtKB/Swiss-Prot:P06567" /translation="MEPIGRSLQGVTGRPDFQKRLEQMKEKVMKDQDVQAFLKENEEV IDQKMIEKSLNKLYEYIEQSKNCSYCSEDENCNNLLEGYHPKLVVNGRSIDIEYYECP VKRKLDQQKKQQSLMKSMYIQQDLLGATFQQVDISDPSRLAMFQHVTDFLKSYNETGK GKGLYLYGKFGVGKTFMLAAIANELAEKEYSSMIVYVPEFVRELKNSLQDQTLEEKLN MVKTTPVLMLDDIGAESMTSWVRDEVIGTVLQHRMSQQLPTFFSSNFSPDELKHHFTY SQRGEKEEVKAARLMERILYLAAPIRLDGENRRHP*" gene complement(2783692..2784627) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" CDS complement(2784655..2786073) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loading protein; replication initiationmembrane attachment protein" /protein_id="NP_390777.1" /db_xref="EnsemblGenomes-Gn:BSU28990" /db_xref="EnsemblGenomes-Tr:CAB14859" /db_xref="GOA:P07908" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="SubtiList:BG10358" /db_xref="UniProtKB/Swiss-Prot:P07908" /translation="MADYWKDVLPVDPYVVKSRSMLQDIDRQIITQLYQPLIGPVAFS LYMTLWGELEQNRLWGGESTHRQLMGMTQSNLKTIHQEQGKLEGIGLLKVYMKESERQ ERLFIYELLPPLRPNEFFEDGMLNVFLYNRVGKTKYQQLKQFFTHPAISEDAKDITRP FNHAFESLQPSEWKLTSDMEETVRLAEGSEYTSVGQSPSYTITEDVFDFDLFLAGLSE TMIPRKAMTQQVRDTIKKLSYLYGIDPLQMQNVVMSAIDERDVITTEALRKAASDWYQ IERNGQLPDLVEKTQPVHLREGEQPAEEDSLDGKLIALLEAISPKKLLQDIADGTEPS KADLKIIEEIMFEQKLEPGVTNVLIYYVMLKTDMKLSKNYIQKIASHWARKKVKTVRE AMKLAIEENRQYLEWAEGKTKSSKRNQKVIREEKLPDWMTEKETASDSESGQQKLHPQ DLEEQKKKMMEEMQKLKKYSAY*" gene complement(2784655..2786073) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" promotor_-10 complement(2786102..2786121) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2786110) /Source="Nicolas_upshifts" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" promotor_-35 complement(2786136..2786139) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2786188..2786646) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16950922, 27920297, 28624879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950922, 27920297, 28624879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of transcription of ribonucleotide reductase nrd genes and operons" /protein_id="NP_390778.1" /db_xref="EnsemblGenomes-Gn:BSU29000" /db_xref="EnsemblGenomes-Tr:CAB14860" /db_xref="GOA:Q45549" /db_xref="InterPro:IPR003796" /db_xref="InterPro:IPR005144" /db_xref="SubtiList:BG13833" /db_xref="UniProtKB/Swiss-Prot:Q45549" /translation="MKCPSCQHNGTRVLDSRPVDDGKSIRRRRECESCHYRFTTFEKV EETPLIVVKKEGVREEFSREKMLRGLIKACEKRPVSLKTLEDMCFDIEKELRNQGCSE VKSELVGEMVMDRLAKIDEVAYVRFASVYRQFKDINVFIDELKDLIKKER*" gene complement(2786188..2786646) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" downshifts complement(2786207) /Source="Nicolas_upshifts" /id="D1486" /incds=0 /nref=14 /ntot=175 /MaxReadThrough="4.1553" /MaxDrop="3.90408" /score="12.4797073" /energy="-21.2" /TU="U2239,U2241" /idTUdmin="U2243" /TUdmin="-9" /isTUend="TRUE" S_feature complement(2786647..2786794) /Source="Nicolas_S_feature" /locus_tag="new_2966140_2966287_c" /HighExp="dia5, dia15, Lbstat, Diami, Heat, M9-stat, M0t90, M40t90, LBGtran, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, SigA" /TUshortPSig="0.998, 0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1091" promotor_-10 complement(2786785..2786804) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-10" upshifts complement(2786794) /Source="Nicolas_upshifts" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" S_feature complement(2786796..2786874) /Source="Nicolas_S_feature" /locus_tag="new_2966289_2966367_c" /HighExp="Lbstat, M40t90, Heat, M9-stat, M0t90, G180, S8, S5, T1.30H, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1092" promotor_-35 complement(2786819..2786822) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-35" downshifts complement(2786919) /Source="Nicolas_upshifts" /id="D1487" /incds=0 /nref=204 /ntot=262 /MaxReadThrough="5.70146" /MaxDrop="5.85416" /score="12.4797073" /energy="-21.2" /TU="U2241,U2242,U2243" /idTUdmin="U2242" /TUdmin="-237" /isTUend="FALSE" CDS complement(2786920..2787300) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" /EC_number="4.1.1.50" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 10844697, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10844697, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine decarboxylase" /protein_id="NP_390779.2" /db_xref="EnsemblGenomes-Gn:BSU29010" /db_xref="EnsemblGenomes-Tr:CAB14861" /db_xref="GOA:O34426" /db_xref="InterPro:IPR003826" /db_xref="InterPro:IPR016067" /db_xref="InterPro:IPR017716" /db_xref="SubtiList:BG13832" /db_xref="UniProtKB/Swiss-Prot:O34426" /translation="METMGRHVISELWGCDFDKLNDMDFIEKTFVNAALKSGAEVREV AFHKFAPQGVSGVVIISESHLTIHSFPEHGYASIDVYTCGDLDPNVAADYIAEALHAD TRENIEIPRGMGPVQIKQAQAKVL*" gene complement(2786920..2787300) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" S_feature complement(2787301..2787455) /Source="Nicolas_S_feature" /locus_tag="new_2966794_2966948_c" /HighExp="Lbstat, M40t90, M9-stat, T2.0H, T3.0H, M0t90, T3.30H, Sw, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1093" promotor_-10 complement(2787435..2787454) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2787442 /Source="Nicolas_upshifts" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 2787443..2787462 /Source="Nicolas_upshift_promotors" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2787455) /Source="Nicolas_upshifts" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" promotor_-35 complement(2787469..2787475) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2787533..2787544) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2787539..2788561) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" /EC_number="1.2.1.59" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NADP-dependent, gluconeogenesis)" /protein_id="NP_390780.1" /db_xref="EnsemblGenomes-Gn:BSU29020" /db_xref="EnsemblGenomes-Tr:CAB14862" /db_xref="GOA:O34425" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12592" /db_xref="UniProtKB/Swiss-Prot:O34425" /translation="MKVKVAINGFGRIGRMVFRKAMLDDQIQVVAINASYSAETLAHL IKYDTIHGRYDKEVVAGEDSLIVNGKKVLLLNSRDPKQLPWREYDIDIVVEATGKFNA KDKAMGHIEAGAKKVILTAPGKNEDVTIVMGVNEDQFDAERHVIISNASCTTNCLAPV VKVLDEEFGIESGLMTTVHAYTNDQKNIDNPHKDLRRARACGESIIPTTTGAAKALSL VLPHLKGKLHGLALRVPVPNVSLVDLVVDLKTDVTAEEVNEAFKRAAKTSMYGVLDYS DEPLVSTDYNTNPHSAVIDGLTTMVMEDRKVKVLAWYDNEWGYSCRVVDLIRHVAARM KHPSAV*" gene complement(2787539..2788561) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" upshifts complement(2787540) /Source="Nicolas_upshifts" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" promotor_-35 complement(2787559..2787565) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2788605..2788624) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2788636) /Source="Nicolas_upshifts" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" promotor_-35 complement(2788637..2788644) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2788767..2789147) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HxlR family)" /protein_id="NP_390781.1" /db_xref="EnsemblGenomes-Gn:BSU29030" /db_xref="EnsemblGenomes-Tr:CAB14863" /db_xref="GOA:O34533" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HZT" /db_xref="SubtiList:BG13831" /db_xref="UniProtKB/Swiss-Prot:O34533" /translation="MEKKKYNISVEATLEVIGGKWKCVILCHLTHGKKRTSELKRLMP NITQKMLTQQLRELEADGVINRIVYNQVPPKVEYELSEYGRSLEGILDMLCAWGANHI NRVYGDTFSVLEESVLNDKLKQES*" gene complement(2788767..2789147) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" downshifts complement(2788791) /Source="Nicolas_upshifts" /id="D1488" /incds=0 /nref=17 /ntot=164 /MaxReadThrough="1.55675" /MaxDrop="3.64816" /score="18.9828659" /energy="-15.3" /TU="NA" /idTUdmin="U2245" /TUdmin=3 /isTUend="TRUE" S_feature complement(2789148..2789278) /Source="Nicolas_S_feature" /locus_tag="new_2968641_2968771_c" /HighExp="dia15, Diami, dia5, LBGstat, G180, Etha, S5, LBGtran, H2O2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1094" promotor_-35 2789203..2789207 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2789223..2789242 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2789224..2789330 /Source="Nicolas_S_feature" /locus_tag="new_2968717_2968823" /HighExp="Diami, G180, G135, LBGstat, G150, LBGexp, Paraq, Oxctl, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1095" upshifts 2789224 /Source="Nicolas_upshifts" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" promotor_-10 complement(2789268..2789287) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2789278) /Source="Nicolas_upshifts" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" promotor_-35 complement(2789302..2789309) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2789331..2790521 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390782.1" /db_xref="EnsemblGenomes-Gn:BSU29040" /db_xref="EnsemblGenomes-Tr:CAB14864" /db_xref="GOA:O34367" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13825" /db_xref="UniProtKB/Swiss-Prot:O34367" /translation="MTSANKSNIPALLALAVSAFAIGTTEFISVGLLPLIADDLDIPV TTAGLTVSLYALGVTFGAPILTSLTSSMSRKTLLLWIMFIFIAGNTMAATASSIGILL AARVISAFSHGVFMSIGSTIAADIVPEDKRASAISIMFTGLTVATVTGVPFGTFIGQQ FGWRFAFMVIIAVGIIAFITNGILVPSKLRKGTKTTMRDQLKLVTNSRLLLLFVITAL GYGGTFVVFTYLSPLLQEVTGFKAGTVAVILLGYGIAIAIGNMIGGKLSNRNPIAALF YMFIVQAIVLFVLTFTAPYQAAGLITILCMGLLAFMNVPGLQVYVVMLAERFVPSAVD VASAMNIAAFNAGIALGSYLGGVITDSIGLIHTAWIGGLMVVGAVILTGWSRLMEKRD RQEA*" gene 2789331..2790521 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" promotor_-10 complement(2790153..2790171) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2790169) /Source="Nicolas_upshifts" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2790187..2790192) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2790545..2791387 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" /EC_number="1.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19585557, 20981419, 28032445, 28130301" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19585557, 20981419, 28032445, 28130301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aldo/keto reductase" /protein_id="NP_390783.1" /db_xref="EnsemblGenomes-Gn:BSU29050" /db_xref="EnsemblGenomes-Tr:CAB14865" /db_xref="GOA:O34678" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3B3D" /db_xref="SubtiList:BG13826" /db_xref="UniProtKB/Swiss-Prot:O34678" /translation="MTTHLQAKATLHNGVEMPWFGLGVFQVEEGSELVNAVKTAIVHG YRSIDTAAIYGNEAGVGEGIREGIEEAGISREDLFITSKVWNADLGYEETLAAFETSL SKLGLDYLDLYLIHWPVEGKYKEAWRALETLYKEGRIKAIGVSNFQIHHLEDLMTAAE IKPMINQVEFHPRLTQKELIRYCQNQGIQMEAWSPLMQGQLLDHPVLADIAQTYNKSV AQIILRWDLQHGIITIPKSTKEHRIKENASVFDFELTQDDMNRIDALNENLRVGPDPD NFDF*" gene 2790545..2791387 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" promotor_-35 2791160..2791165 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2791181..2791199 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2791182 /Source="Nicolas_upshifts" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2791380 /Source="Nicolas_upshifts" /id="D1489" /incds=0 /nref=13 /ntot=124 /MaxReadThrough="1.16017" /MaxDrop="5.72508" /score="24.0721062" /energy="-11.4" /TU="NA" /idTUdmin="U2244" /TUdmin=0 /isTUend="TRUE" downshifts complement(2791420) /Source="Nicolas_upshifts" /id="D1490" /incds=0 /nref=168 /ntot=263 /MaxReadThrough="3.38494" /MaxDrop="6.57333" /score="13.4291259" /energy="-11.4" /TU="NA" /idTUdmin="U2248" /TUdmin="-8" /isTUend="TRUE" CDS complement(2791429..2792022) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" /EC_number="2.7.1.24" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 11886213, 12538896, 12682299, 15044829, 15526298, 17603993; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphocoenzyme A kinase" /protein_id="NP_390784.1" /db_xref="EnsemblGenomes-Gn:BSU29060" /db_xref="EnsemblGenomes-Tr:CAB14866" /db_xref="GOA:O34932" /db_xref="InterPro:IPR001977" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13824" /db_xref="UniProtKB/Swiss-Prot:O34932" /translation="MTLVIGLTGGIASGKSTVANMLIEKGITVIDADIIAKQAVEKGM PAYRQIIDEFGEDILLSNGDIDRKKLGALVFTNEQKRLALNAIVHPAVRQEMLNRRDE AVANREAFVVLDIPLLFESKLESLVDKIIVVSVTKELQLERLMKRNQLTEEEAVSRIR SQMPLEEKTARADQVIDNSGTLEETKRQLDEIMNSWA*" gene complement(2791429..2792022) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" CDS complement(2792038..2792670) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23396918; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="membrane calmodulin-like protein essential for stage III sporulation" /protein_id="NP_390785.2" /db_xref="EnsemblGenomes-Gn:BSU29070" /db_xref="EnsemblGenomes-Tr:CAB14867" /db_xref="GOA:C0SP79" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR014205" /db_xref="SubtiList:BG13823" /db_xref="UniProtKB/Swiss-Prot:C0SP79" /translation="MQMVSILLLALAVSLDSFSVGFTYGLRKMKIPFKAILVIACCSG AVMFISMLIGSFLTKFFPVYVTEKLGGLILVGIGAWVLYQFFKPAKDKEYLLHEKTLL NLEVRSLGIVIHILRKPMSADIDKSGVINGIEAVLLGFALSIDAFGAGIGAAILGFSP IVMSIAVAIMSSLFVSIGINAGHFLSKWKWIDKMAFLPGLLLITIGLWKL*" gene complement(2792038..2792670) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" S_feature complement(2792671..2792835) /Source="Nicolas_S_feature" /locus_tag="new_2972164_2972328_c" /HighExp="LPhT, dia15, Sw, LBGtran, LBGstat, H2O2, Diami, G135, Lbstat, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1096" CDS complement(2792836..2793666) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" /EC_number="3.2.2.23" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15109717, 25825434, 28517932; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formamidopyrimidine-DNA glycosylase; 5-hydroxymethyl-uracil DNA-glycosylase" /protein_id="NP_390786.2" /db_xref="EnsemblGenomes-Gn:BSU29080" /db_xref="EnsemblGenomes-Tr:CAB14868" /db_xref="GOA:O34403" /db_xref="InterPro:IPR000214" /db_xref="InterPro:IPR010663" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR012319" /db_xref="InterPro:IPR015886" /db_xref="InterPro:IPR015887" /db_xref="InterPro:IPR020629" /db_xref="InterPro:IPR035937" /db_xref="SubtiList:BG12628" /db_xref="UniProtKB/Swiss-Prot:O34403" /translation="MPELPEVETVRRTLTGLVKGKTIKSVEIRWPNIIKRPAEPEEFA RKLAGETIQSIGRRGKFLLFHLDHYVMVSHLRMEGKYGLHQAEEPDDKHVHVIFTMTD GTQLRYRDVRKFGTMHLFKPGEEAGELPLSQLGPEPDAEEFTSAYLKDRLAKTNRAVK TALLDQKTVVGLGNIYVDEALFRAGVHPETKANQLSDKTIKTLHAEIKNTLQEAIDAG GSTVRSYINSQGEIGMFQLQHFVYGKKDEPCKNCGTMISKIVVGGRGTHFCAKCQTKK *" gene complement(2792836..2793666) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" CDS complement(2793689..2796331) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" /EC_number="2.7.7.7" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3125407, 6777244, 9231429, 12081953, 17905985, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3125407, 6777244, 9231429, 12081953, 17905985, 27399782; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase I" /protein_id="NP_390787.1" /db_xref="EnsemblGenomes-Gn:BSU29090" /db_xref="EnsemblGenomes-Tr:CAB14869" /db_xref="GOA:O34996" /db_xref="InterPro:IPR001098" /db_xref="InterPro:IPR002298" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR002562" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR018320" /db_xref="InterPro:IPR019760" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12656" /db_xref="UniProtKB/Swiss-Prot:O34996" /translation="MTERKKLVLVDGNSLAYRAFFALPLLSNDKGVHTNAVYGFAMIL MKMLEDEKPTHMLVAFDAGKTTFRHGTFKEYKGGRQKTPPELSEQMPFIRELLDAYQI SRYELEQYEADDIIGTLAKSAEKDGFEVKVFSGDKDLTQLATDKTTVAITRKGITDVE FYTPEHVKEKYGLTPEQIIDMKGLMGDSSDNIPGVPGVGEKTAIKLLKQFDSVEKLLE SIDEVSGKKLKEKLEEFKDQALMSKELATIMTDAPIEVSVSGLEYQGFNREQVIAIFK DLGFNTLLERLGEDSAEAEQDQSLEDINVKTVTDVTSDILVSPSAFVVEQIGDNYHEE PILGFSIVNETGAYFIPKDIAVESEVFKEWVENDEQKKWVFDSKRAVVALRWQGIELK GAEFDTLLAAYIINPGNSYDDVASVAKDYGLHIVSSDESVYGKGAKRAVPSEDVLSEH LGRKALAIQSLREKLVQELENNDQLELFEELEMPLALILGEMESTGVKVDVDRLKRMG EELGAKLKEYEEKIHEIAGEPFNINSPKQLGVILFEKIGLPVVKKTKTGYSTSADVLE KLADKHDIVDYILQYRQIGKLQSTYIEGLLKVTRPDSHKVHTRFNQALTQTGRLSSTD PNLQNIPIRLEEGRKIRQAFVPSEKDWLIFAADYSQIELRVLAHISKDENLIEAFTND MDIHTKTAMDVFHVAKDEVTSAMRRQAKAVNFGIVYGISDYGLSQNLGITRKEAGAFI DRYLESFQGVKAYMEDSVQEAKQKGYVTTLMHRRRYIPELTSRNFNIRSFAERTAMNT PIQGSAADIIKKAMIDMAAKLKEKQLKARLLLQVHDELIFEAPKEEIEILEKLVPEVM EHALALDVPLKVDFASGPSWYDAK*" gene complement(2793689..2796331) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" promotor_-10 complement(2796386..2796405) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2796395) /Source="Nicolas_upshifts" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" promotor_-35 complement(2796419..2796426) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2796455..2796574) /Source="Nicolas_S_feature" /locus_tag="new_2975948_2976067_c" /HighExp="M0t90, M40t90, M9-stat, Lbstat, Sw, T1.30H, T1.0H, S4, S3, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1097" downshifts complement(2796498) /Source="Nicolas_upshifts" /id="D1491" /incds=0 /nref=48 /ntot=175 /MaxReadThrough="5.58383" /MaxDrop="3.85702" /score="15.0073484" /energy="-12.2" /TU="U2249" /idTUdmin="U2254" /TUdmin="-3" /isTUend="TRUE" CDS complement(2796575..2798314) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_390788.1" /db_xref="EnsemblGenomes-Gn:BSU29100" /db_xref="EnsemblGenomes-Tr:CAB14870" /db_xref="GOA:P23545" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR031967" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3CWF" /db_xref="SubtiList:BG10364" /db_xref="UniProtKB/Swiss-Prot:P23545" /translation="MNKYRVRLFSVFVVCMILVFCVLGLFLQQLFETSDQRKAEEHIE KEAKYLASLLDAGNLNNQANEKIIKDAGGALDVSASVIDTDGKVLYGSNGRSADSQKV QALVSGHEGILSTTDNKLYYGLSLRSEGEKTGYVLLSASEKSDGLKGELWGMLTASLC TAFIVIVYFYSSMTSRYKRSIESATNVATELSKGNYDARTYGGYIRRSDKLGHAMNSL AIDLMEMTRTQEMQRDRLLTVIENIGSGLIMIDGRGFINLVNRSYAKQFHINPNHMLR RLYHDAFEHEEVIQLVEDIFMTETKKCKLLRLPIKIERRYFEVDGVPIMGPDDEWKGI VLVFHDMTETKKLEQMRKDFVANVSHELKTPITSIKGFTETLLDGAMEDKEALSEFLS IILKESERLQSLVQDLLDLSKIEQQNFTLSIETFEPAKMLGEIETLLKHKADEKGISL HLNVPKDPQYVSGDPYRLKQVFLNLVNNALTYTPEGGSVAINVKPREKDIQIEVADSG IGIQKEEIPRIFERFYRVDKDRSRNSGGTGLGLAIVKHLIEAHEGKIDVTSELGRGTV FTVTLKRAAEKSA*" gene complement(2796575..2798314) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" CDS complement(2798307..2799029) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_390789.2" /db_xref="EnsemblGenomes-Gn:BSU29110" /db_xref="EnsemblGenomes-Tr:CAB14871" /db_xref="GOA:P13792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1MVO" /db_xref="SubtiList:BG10363" /db_xref="UniProtKB/Swiss-Prot:P13792" /translation="MNKKILVVDDEESIVTLLQYNLERSGYDVITASDGEEALKKAET EKPDLIVLDVMLPKLDGIEVCKQLRQQKLMFPILMLTAKDEEFDKVLGLELGADDYMT KPFSPREVNARVKAILRRSEIAAPSSEMKNDEMEGQIVIGDLKILPDHYEAYFKESQL ELTPKEFELLLYLGRHKGRVLTRDLLLSAVWNYDFAGDTRIVDVHISHLRDKIENNTK KPIYIKTIRGLGYKLEEPKMNE*" gene complement(2798307..2799029) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" promotor_-10 complement(2799097..2799116) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2799107) /Source="Nicolas_upshifts" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" S_feature complement(2799109..2799209) /Source="Nicolas_S_feature" /locus_tag="new_2978602_2978702_c" /HighExp="M40t90, T1.30H, T1.0H, M0t90, M9-stat, T2.0H, T2.30H, T3.0H, T0.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1098" promotor_-35 complement(2799130..2799136) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2799241..2800179) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" /EC_number="1.1.1.37" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate dehydrogenase (NAD-dependent)" /protein_id="NP_390790.1" /db_xref="EnsemblGenomes-Gn:BSU29120" /db_xref="EnsemblGenomes-Tr:CAB14872" /db_xref="GOA:P49814" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011275" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11386" /db_xref="UniProtKB/Swiss-Prot:P49814" /translation="MGNTRKKVSVIGAGFTGATTAFLIAQKELADVVLVDIPQLENPT KGKALDMLEASPVQGFDAKITGTSNYEDTAGSDIVVITAGIARKPGMSRDDLVSTNEK IMRSVTQEIVKYSPDSIIVVLTNPVDAMTYAVYKESGFPKERVIGQSGVLDTARFRTF VAEELNLSVKDVTGFVLGGHGDDMVPLVRYSYAGGIPLETLIPKERIDAIVERTRKGG GEIVNLLGNGSAYYAPAASLTEMVEAILKDQRRVLPTIAYLEGEYGYEGIYLGVPTIV GGNGLEQIIELELTDYERAQLNKSVESVKNVMKVLS*" gene complement(2799241..2800179) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" downshifts complement(2799254) /Source="Nicolas_upshifts" /id="D1492" /incds=0 /nref=200 /ntot=242 /MaxReadThrough="8.27126" /MaxDrop="7.40884" /score="-0.758981483" /energy="-13.5" /TU="U2251,U2254" /idTUdmin="U2250" /TUdmin="-9" /isTUend="TRUE" CDS complement(2800223..2801494) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" /EC_number="1.1.1.42" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8045898, 9244258, 11290745, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045898, 9244258, 11290745, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isocitrate dehydrogenase" /protein_id="NP_390791.1" /db_xref="EnsemblGenomes-Gn:BSU29130" /db_xref="EnsemblGenomes-Tr:CAB14873" /db_xref="GOA:P39126" /db_xref="InterPro:IPR004439" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="PDB:1HQS" /db_xref="SubtiList:BG10856" /db_xref="UniProtKB/Swiss-Prot:P39126" /translation="MAQGEKITVSNGVLNVPNNPIIPFIEGDGTGPDIWNAASKVLEA AVEKAYKGEKKITWKEVYAGEKAYNKTGEWLPAETLDVIREYFIAIKGPLTTPVGGGI RSLNVALRQELDLFVCLRPVRYFTGVPSPVKRPEDTDMVIFRENTEDIYAGIEYAKGS EEVQKLISFLQNELNVNKIRFPETSGIGIKPVSEEGTSRLVRAAIDYAIEHGRKSVTL VHKGNIMKFTEGAFKNWGYELAEKEYGDKVFTWAQYDRIAEEQGKDAANKAQSEAEAA GKIIIKDSIADIFLQQILTRPNEFDVVATMNLNGDYISDALAAQVGGIGIAPGANINY ETGHAIFEATHGTAPKYAGLDKVNPSSVILSGVLLLEHLGWNEAADLVIKSMEKTIAS KVVTYDFARLMDGATEVKCSEFGEELIKNMD*" gene complement(2800223..2801494) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" misc_feature complement(2801279..2801298) /Source="Nicolas_upshift_promotors" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2801291) /Source="Nicolas_upshifts" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" S_feature complement(2801495..2801577) /Source="Nicolas_S_feature" /locus_tag="new_2980988_2981070_c" /HighExp="T2.30H, M40t90, T1.0H, T-3.40H, HiOs, T3.30H, T3.0H, T0.0H, Lbstat, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1099" upshifts complement(2801577) /Source="Nicolas_upshifts" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" S_feature complement(2801579..2801657) /Source="Nicolas_S_feature" /locus_tag="new_2981072_2981150_c" /HighExp="T2.30H, T3.30H, T1.0H, M40t90, T3.0H, Lbstat, M0t90, T0.0H, HiOs, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1100" promotor_-10 complement(2801579..2801598) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-10" promotor_-35 complement(2801614..2801618) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-35" CDS complement(2801658..2802776) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase II" /protein_id="NP_390792.1" /db_xref="EnsemblGenomes-Gn:BSU29140" /db_xref="EnsemblGenomes-Tr:CAB14874" /db_xref="GOA:P39120" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR011278" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG10855" /db_xref="UniProtKB/Swiss-Prot:P39120" /translation="MTATRGLEGVVATTSSVSSIIDDTLTYVGYDIDDLTENASFEEI IYLLWHLRLPNKKELEELKQQLAKEAAVPQEIIEHFKSYSLENVHPMAALRTAISLLG LLDSEADTMNPEANYRKAIRLQAKVPGLVAAFSRIRKGLEPVEPREDYGIAENFLYTL NGEEPSPIEVEAFNKALILHADHELNASTFTARVCVATLSDIYSGITAAIGALKGPLH GGANEGVMKMLTEIGEVENAEPYIRAKLEKKEKIMGFGHRVYKHGDPRAKHLKEMSKR LTNLTGESKWYEMSIRIEDIVTSEKKLPPNVDFYSASVYHSLGIDHDLFTPIFAVSRM SGWLAHILEQYDNNRLIRPRADYTGPDKQKFVPIEERA*" gene complement(2801658..2802776) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" downshifts 2802271 /Source="Nicolas_upshifts" /id="D1493" /incds=1 /nref=2 /ntot=63 /MaxReadThrough="1.41638" /MaxDrop="3.70762" /score="40.6931963" /energy="-9.9" /TU="NA" /idTUdmin="U2252" /TUdmin="-506" /isTUend="FALSE" misc_feature 2802618..2802621 /Source="Nicolas_upshift_promotors" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2802626 /Source="Nicolas_upshifts" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2802755 /Source="Nicolas_upshifts" /id="D1494" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="2.98678" /MaxDrop="3.07929" /score="40.6931963" /energy="-9.9" /TU="U2252" /idTUdmin="U2252" /TUdmin="-22" /isTUend="TRUE" S_feature complement(2802777..2802983) /Source="Nicolas_S_feature" /locus_tag="new_2982270_2982476_c" /HighExp="T3.0H, T3.30H, T2.30H, T4.0H, M0t90, T2.0H, T1.30H, T5.0H, BC, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1101" misc_feature 2802951..2802963 /Source="Nicolas_upshift_promotors" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2802962 /Source="Nicolas_upshifts" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2802969..2802988) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2802983) /Source="Nicolas_upshifts" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" promotor_-35 complement(2803003..2803007) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2803103) /Source="Nicolas_upshifts" /id="D1495" /incds=0 /nref=116 /ntot=204 /MaxReadThrough="6.4946" /MaxDrop="5.00031" /score="29.3344463" /energy="-8.1" /TU="NA" /idTUdmin="U2255" /TUdmin=14 /isTUend="TRUE" CDS complement(2803110..2803574) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390793.1" /db_xref="EnsemblGenomes-Gn:BSU29150" /db_xref="EnsemblGenomes-Tr:CAB14875" /db_xref="GOA:O34811" /db_xref="InterPro:IPR007382" /db_xref="SubtiList:BG13933" /db_xref="UniProtKB/Swiss-Prot:O34811" /translation="MFTQANLFLILLLAIALIAKNQSLLFAVSVLLIIKIVGLDQKLF PTIQSKGINWGVTIITIAVLVPIATGEIGFKQLGEAMRSSYAWIALGAGIAVALIAKN GLTLLENDPHITTALVIGTILAVALFGGVAVGPLIGAGIAYLAMQIVKLFTS*" gene complement(2803110..2803574) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" promotor_-10 complement(2803587..2803606) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2803601) /Source="Nicolas_upshifts" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" S_feature complement(2803603..2804788) /Source="Nicolas_S_feature" /locus_tag="new_2983096_2984281_c" /HighExp="G135, G180, LBGstat, G150, LBGtran, S0, Paraq, Oxctl, H2O2, LBGexp" /AntisenseName="ytvI" /AntisenseCor="-0.73323145377324295" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1102" promotor_-35 2803603..2803608 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2803619..2803627) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2803623..2803641 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2803629 /Source="Nicolas_upshifts" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" CDS 2803671..2804786 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12662922, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sporulation-related permease" /protein_id="NP_390794.1" /db_xref="EnsemblGenomes-Gn:BSU29160" /db_xref="EnsemblGenomes-Tr:CAB14876" /db_xref="GOA:O34991" /db_xref="InterPro:IPR002549" /db_xref="InterPro:IPR014227" /db_xref="SubtiList:BG13930" /db_xref="UniProtKB/Swiss-Prot:O34991" /translation="MNQSYITIFFRTLFVISMTAGSIAAAYYSFPLTYPFLIALILSS VIHPVVDYLDKVTGFPRTINVLGVLAFFLLAAFGVLTILVAEIVTGTAYLAKTLPPHI STFISYCEKLFTTHIQPLYNELTLLFQELETNQQASIVTHIQTLGDSAAKNAGLLLSH ILEMIPRFFALLPNTAAVLIFSLLATFFMTKDWHKLKAMLVLILPDRVTANSKAISSE LKKAMTGFIKAQAVLVFITMVIVFIGLSLLKVEHAATIAFLIGLVDLLPYLGAGSVFV PWILYLSITGQLPQAIGIGILYLVVLIQRQLTEPKILSKSIGIDPLATLIALFAGFKL FGFLGLIAGPAVLVIIQAFITTGALKEIWSYITVQQK*" gene 2803671..2804786 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" downshifts 2804757 /Source="Nicolas_upshifts" /id="D1496" /incds=0 /nref=2 /ntot=24 /MaxReadThrough="1.639" /MaxDrop="3.31897" /score="37.6858539" /energy="-16.7" /TU="NA" /idTUdmin="U2256" /TUdmin=0 /isTUend="TRUE" CDS complement(2804819..2805202) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15302217, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390795.1" /db_xref="EnsemblGenomes-Gn:BSU29170" /db_xref="EnsemblGenomes-Tr:CAB14877" /db_xref="GOA:O32064" /db_xref="InterPro:IPR007313" /db_xref="SubtiList:BG13935" /db_xref="UniProtKB/Swiss-Prot:O32064" /translation="MRFLFLLFIVFPAIEIGIFLFLGNLIGILPTVLFMILTGIIGAA AAKKQGTEVYYKVQRDLQYGKMPGEAIADGLCIFIGGLLLMLPGFLSDLAGACLLIPF TRGWCKPILFKWLRGMSKNKRIIIK*" gene complement(2804819..2805202) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" downshifts complement(2804833) /Source="Nicolas_upshifts" /id="D1497" /incds=0 /nref=181 /ntot=256 /MaxReadThrough="4.28884" /MaxDrop="5.74703" /score="18.319512" /energy="-13.8" /TU="NA" /idTUdmin="U2257" /TUdmin=0 /isTUend="TRUE" S_feature complement(2805203..2805294) /Source="Nicolas_S_feature" /locus_tag="new_2984696_2984787_c" /HighExp="G135, LBGtran, G150, LBGexp, M0t45, Lbexp, S0, G180, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1103" CDS complement(2805295..2807052) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" /EC_number="2.7.1.40" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate kinase" /protein_id="NP_390796.1" /db_xref="EnsemblGenomes-Gn:BSU29180" /db_xref="EnsemblGenomes-Tr:CAB14878" /db_xref="GOA:P80885" /db_xref="InterPro:IPR001697" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR011037" /db_xref="InterPro:IPR015793" /db_xref="InterPro:IPR015795" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018209" /db_xref="InterPro:IPR036918" /db_xref="SubtiList:BG12661" /db_xref="UniProtKB/Swiss-Prot:P80885" /translation="MRKTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFEEHG ARIKNIREASKKLGKNVGILLDTKGPEIRTHTMENGGIELETGKELIISMDEVVGTTD KISVTYEGLVHDVEQGSTILLDDGLIGLEVLDVDAAKREIKTKVLNNGTLKNKKGVNV PGVSVNLPGITEKDARDIVFGIEQGVDFIAPSFIRRSTDVLEIRELLEEHNAQDIQII PKIENQEGVDNIDAILEVSDGLMVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVIT ATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGSYPVEAVQTMHNIASR SEEALNYKEILSKRRDQVGMTITDAIGQSVAHTAINLNAAAIVTPTESGHTARMIAKY RPQAPIVAVTVNDSISRKLALVSGVFAESGQNASSTDEMLEDAVQKSLNSGIVKHGDL IVITAGTVGESGTTNLMKVHTVGDIIAKGQGIGRKSAYGPVVVAQNAKEAEQKMTDGA VLVTKSTDRDMIASLEKASALITEEGGLTSHAAVVGLSLGIPVIVGLENATSILTDGQ DITVDASRGAVYQGRASVL*" gene complement(2805295..2807052) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" CDS complement(2807095..2808054) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" /EC_number="2.7.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12450869, 12622823, 12682299, 19193632, 20473954, 22198292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450869, 12622823, 12682299, 19193632, 20473954, 22198292; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phosphofructokinase" /protein_id="NP_390797.1" /db_xref="EnsemblGenomes-Gn:BSU29190" /db_xref="EnsemblGenomes-Tr:CAB14879" /db_xref="GOA:O34529" /db_xref="InterPro:IPR000023" /db_xref="InterPro:IPR012003" /db_xref="InterPro:IPR012828" /db_xref="InterPro:IPR015912" /db_xref="InterPro:IPR022953" /db_xref="InterPro:IPR035966" /db_xref="PDB:4A3S" /db_xref="SubtiList:BG12644" /db_xref="UniProtKB/Swiss-Prot:O34529" /translation="MKRIGVLTSGGDSPGMNAAVRAVVRKAIYHDVEVYGIYNGYAGL ISGKIEKLELGSVGDIIHRGGTKLYTARCPEFKTVEGREKGIANLKKLGIEGLVVIGG DGSYMGAKKLTEHGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSH ERTYVIEVMGRHAGDIALWAGLAGGAESILIPEADYDMHEIIARLKRGHERGKKHSII IVAEGVGSGVEFGKRIEEETNLETRVSVLGHIQRGGSPSAADRVLASRLGAYAVELLL EGKGGRCVGIQNNKLVDHDIIEILETKHTVEQNMYQLSKELSI*" gene complement(2807095..2808054) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" S_feature complement(2808055..2808156) /Source="Nicolas_S_feature" /locus_tag="new_2987548_2987649_c" /HighExp="G150, LBGtran, LBGexp, Lbexp, dia0, G180, G135, Oxctl, LBGstat, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1104" promotor_-10 complement(2808145..2808164) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2808156) /Source="Nicolas_upshifts" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" promotor_-35 complement(2808180..2808184) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2808238..2809215) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase alpha subunit)" /protein_id="NP_390798.1" /db_xref="EnsemblGenomes-Gn:BSU29200" /db_xref="EnsemblGenomes-Tr:CAB14880" /db_xref="GOA:O34847" /db_xref="InterPro:IPR001095" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12557" /db_xref="UniProtKB/Swiss-Prot:O34847" /translation="MAPRLEFEKPVIELQTKIAELKKFTQDSDMDLSAEIERLEDRLA KLQDDIYKNLKPWDRVQIARLADRPTTLDYIEHLFTDFFECHGDRAYGDDEAIVGGIA KFHGLPVTVIGHQRGKDTKENLVRNFGMPHPEGYRKALRLMKQADKFNRPIICFIDTK GAYPGRAAEERGQSEAIAKNLFEMAGLRVPVICIVIGEGGSGGALGLGVGNHLHMLEN STYSVISPEGAAALLWKDSSLAKKAAETMKITAPDLKELGIIDHMIKEVKGGAHHDVK LQASYMDETLKQSLKTLLKLSEEELVQQRYEKYKAIGKVSVEDQYIGVN*" gene complement(2808238..2809215) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" downshifts complement(2808265) /Source="Nicolas_upshifts" /id="D1498" /incds=0 /nref=48 /ntot=176 /MaxReadThrough="5.40549" /MaxDrop="5.53933" /score="-3.96100458" /energy="-6.8" /TU="U2259,U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-88" /isTUend="FALSE" CDS complement(2809200..2810072) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" /EC_number="6.4.1.2" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 14594796, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase betasubunit)" /protein_id="NP_390799.2" /db_xref="EnsemblGenomes-Gn:BSU29210" /db_xref="EnsemblGenomes-Tr:CAB14881" /db_xref="GOA:C0SP93" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13926" /db_xref="UniProtKB/Swiss-Prot:C0SP93" /translation="MLKDIFTKKKKYASVPSDQAKHDVPEGIMTKCPKCKKIMLTKEL DKNMRVCMNCDYHFPMNAKQRIESLMDEQSFEEFNQGMLSENPLGFPGYLEKLEKDRE KTSLNEAVVTGKGTIGGHPAVVAVMDSSFRMGSMGSVVGEKITLAIEKAKADKVPFII FTASGGARMQEGVLSLMQMAKTSSALKLFSEEQGLIISVMTHPTTGGVSASFASLGDY NFAEPGALIGFAGRRIIEQTIGEKLPEDFQTAEFLLKHGQLDAVIHRDDMKKTLENLL DMHQTGGDIEWLQD*" gene complement(2809200..2810072) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" promotor_-35 2810034..2810039 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2810055..2810073 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2810059..2811233 /Source="Nicolas_S_feature" /locus_tag="new_2989552_2990726" /HighExp="S5, S8, S6, S7, C30, S4, C90, S3, T5.0H, BC" /AntisenseName="ytsJ" /AntisenseCor="-0.46008986922877199" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1105" upshifts 2810059 /Source="Nicolas_upshifts" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" S_feature complement(2810073..2810156) /Source="Nicolas_S_feature" /locus_tag="new_2989566_2989649_c" /HighExp="LBGstat, T4.0H, LBGtran, T5.0H, C30, dia15, M9-stat, Oxctl, LBGexp, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1106" promotor_-10 complement(2810145..2810164) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2810156) /Source="Nicolas_upshifts" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" S_feature complement(2810158..2810310) /Source="Nicolas_S_feature" /locus_tag="new_2989651_2989803_c" /HighExp="Diami, BC, dia15, Sw, dia5, M40t90, H2O2, S2, G/S, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1107" promotor_-35 complement(2810180..2810184) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2810312..2810406) /Source="Nicolas_S_feature" /locus_tag="new_2989805_2989899_c" /HighExp="dia15, LBGtran, LBGstat, Diami, LoTm, C90, GM 120, MG 60, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1108" downshifts complement(2810355) /Source="Nicolas_upshifts" /id="D1499" /incds=0 /nref=52 /ntot=158 /MaxReadThrough="7.72399" /MaxDrop="4.5863" /score="-3.96100458" /energy="-6.8" /TU="U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-2178" /isTUend="FALSE" CDS complement(2810407..2811639) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" /EC_number="1.1.1.40" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 22740702, 23136871, 24325460, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 22740702, 23136871, 24325460, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP-dependent malic enzyme (conversion of malate into pyruvate, anabolic)" /protein_id="NP_390800.1" /db_xref="EnsemblGenomes-Gn:BSU29220" /db_xref="EnsemblGenomes-Tr:CAB14882" /db_xref="GOA:O34962" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG13922" /db_xref="UniProtKB/Swiss-Prot:O34962" /translation="MSLREEALHLHKVNQGKLESKSKVEVRNAKDLSLAYSPGVAEPC KDIHEDINKVYDYTMKGNMVAVVTDGTAVLGLGNIGPEAALPVMEGKAVLFKSFAGVD AFPIALNTNDVDKIVETVKLLEPTFGGVNLEDIAAPNCFIIEERLKKETNIPVFHDDQ HGTAIVTVAGLVNALKLSGKSMSSIKVVANGAGAAGIAIIKLLHHYGVRDIVMCDSKG AIYEGRPNGMNDVKNEVAKFTNQDRKDGSLKDVIVDADVFIGVSVAGALTKEMVQSMA KDPIIFAMANPNPEIMPEDAREAGASVVGTGRSDFPNQVNNVLAFPGIFRGALDVRAT HINEEMKIAAVEAIASLVSEDELSADYVIPAPFDKRVAPAVAKAVAKAAMETGVARIT VDPEEVAEKTRKLTIIGE*" gene complement(2810407..2811639) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" S_feature complement(2811640..2811756) /Source="Nicolas_S_feature" /locus_tag="new_2991133_2991249_c" /HighExp="dia15, Diami, LBGstat, H2O2, LBGtran, dia5, M40t45, Lbtran, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1109" promotor_-10 complement(2811744..2811763) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2811756) /Source="Nicolas_upshifts" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" CDS complement(2811776..2815123) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit), DnaE3" /protein_id="NP_390801.1" /db_xref="EnsemblGenomes-Gn:BSU29230" /db_xref="EnsemblGenomes-Tr:CAB14883" /db_xref="GOA:O34623" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004805" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR029460" /db_xref="SubtiList:BG12583" /db_xref="UniProtKB/Swiss-Prot:O34623" /translation="MSFVHLQVHSGYSLLNSAAAVEELVSEADRLGYASLALTDDHVM YGAIQFYKACKARGINPIIGLTASVFTDDSELEAYPLVLLAKSNTGYQNLLKISSVLQ SKSKGGLKPKWLHSYREGIIAITPGEKGYIETLLEGGLFEQAAQASLEFQSIFGKGAF YFSYQPFKGNQVLSEQILKLSEETGIPVTATGDVHYIRKEDKAAYRCLKAIKAGEKLT DAPAEDLPDLDLKPLEEMQNIYREHPEALQASVEIAEQCRVDVSLGQTRLPSFPTPDG TSADDYLTDICMEGLRSRFGKPDERYLRRLQYELDVIKRMKFSDYFLIVWDFMKHAHE KGIVTGPGRGSAAGSLVAYVLYITDVDPIKHHLLFERFLNPERVSMPDIDIDFPDTRR DEVIQYVQQKYGAMHVAQIITFGTLAAKAALRDVGRVFGVSPKEADQLAKLIPSRPGM TLDEARQQSPQLDKRLRESSLLQQVYSIARKIEGLPRHASTHAAGVVLSEEPLTDVVP LQEGHEGIYLTQYAMDHLEDLGLLKMDFLGLRNLTLIESITSMIEKEENIKIDLSSIS YSDDKTFSLLSKGDTTGIFQLESAGMRSVLKRLKPSGLEDIVAVNALYRPGPMENIPL FIDRKHGRAPVHYPHEDLRSILEDTYGVIVYQEQIMMIASRMAGFSLGEADLLRRAVS KKKKEILDRERSHFVEGCLKKEYSVDTANEVYDLIVKFANYGFNRSHAVAYSMIGCQL AYLKAHYPLYFMCGLLTSVIGNEDKISQYLYEAKGSGIRILPPSVNKSSFPFTVENGS VRYSLRAIKSVGVSAVKDIYKARKEKPFEDLFDFCFRVPSKSVNRKMLEALIFSGAMD EFGQNRATLLASIDVALEHAELFAADDDQMGLFLDESFSIKPKYVETEELPLVDLLAF EKETLGIYFSNHPLSAFRKQLTAQGAVSILQAQRAVKRQLSLGVLLSKIKTIRTKTGQ NMAFLTLSDETGEMEAVVFPEQFRQLSPVLREGALLFTAGKCEVRQDKIQFIMSRAEL LEDMDAEKAPSVYIKIESSQHSQEILAKIKRILLEHKGETGVYLYYERQKQTIKLPES FHINADHQVLYRLKELLGQKNVVLKQW*" gene complement(2811776..2815123) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" promotor_-35 complement(2811777..2811784) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2812788..2812797 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2812809..2812824 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2812809 /Source="Nicolas_upshifts" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2812997..2813016) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2813016) /Source="Nicolas_upshifts" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" promotor_-35 complement(2813030..2813037) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2815154..2815173) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2815172) /Source="Nicolas_upshifts" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" promotor_-35 complement(2815187..2815194) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2815212..2815217 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-35" upshifts 2815229 /Source="Nicolas_upshifts" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" promotor_-10 2815233..2815251 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-10" CDS 2815263..2815604 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="membrane protein involved in a sporulation process" /protein_id="YP_003097771.1" /db_xref="EnsemblGenomes-Gn:BSU29239" /db_xref="EnsemblGenomes-Tr:CAX52677" /db_xref="GOA:C0H3P8" /db_xref="InterPro:IPR025689" /db_xref="UniProtKB/Swiss-Prot:C0H3P8" /translation="MDQEAGFMVNFINSYFIALGVLIGGALIGGLGAYLAGEPPLTAI TKLANRLKIWALVAAIGGTFDAVYSFERGILEGNTRDIFKQLLLIISAMGGAQSGWLI ISWLTQEHLSS*" gene 2815263..2815604 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" CDS 2815601..2816104 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="protein involved in sporulation" /protein_id="NP_390802.3" /db_xref="EnsemblGenomes-Gn:BSU29240" /db_xref="EnsemblGenomes-Tr:CAB14884" /db_xref="GOA:O34460" /db_xref="SubtiList:BG13917" /db_xref="UniProtKB/Swiss-Prot:O34460" /translation="MRVPQHYKKPGWQRFFAGMMCGAVISWFFFLFTYGTFQEEQVSL IEKQKEHVKDLNNQISIYQEDLHKLNEDNKRKLLIQSVSVKLLNGDKYKISQPDKTKF EEHVKDDISEVITKDIESVYQTKDLLKRTIENKVYMINEKKYEATVRELIIYTRLTVE LEISFAT*" gene 2815601..2816104 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" promotor_-35 2816137..2816140 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2816155..2816174 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2816155 /Source="Nicolas_upshifts" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" CDS 2816206..2816397 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative sporulation-related conserved protein" /protein_id="YP_003097772.1" /db_xref="EnsemblGenomes-Gn:BSU29249" /db_xref="EnsemblGenomes-Tr:CAX52678" /db_xref="UniProtKB/Swiss-Prot:C0H3P9" /translation="MEVYSDRQLAKDQAARLRQGFSAYAETNSLASLIKKELQSHNLQ VYEDLTDFGCWFIPVTDEH*" gene 2816206..2816397 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" downshifts complement(2816207) /Source="Nicolas_upshifts" /id="D1500" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.45109" /MaxDrop="3.19151" /score="-1.37123732" /energy="-6.5" /TU="NA" /idTUdmin="U2268" /TUdmin=220 /isTUend="FALSE" downshifts 2816373 /Source="Nicolas_upshifts" /id="D1501" /incds=0 /nref=15 /ntot=107 /MaxReadThrough="6.88261" /MaxDrop="6.74738" /score="-8.58003897" /energy="-4" /TU="U2265" /idTUdmin="U2264" /TUdmin=242 /isTUend="FALSE" CDS complement(2816415..2817356) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" /EC_number="3.1.3.7" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17586819, 19553197, 22102036, 26735940, 28894100" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17586819, 19553197, 22102036, 26735940, 28894100; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nanoRNase (oligoribonuclease) (3'->5'short substrates, 5'->3' long substrates), 3',5'-bisphosphate nucleotidase" /protein_id="NP_390803.1" /db_xref="EnsemblGenomes-Gn:BSU29250" /db_xref="EnsemblGenomes-Tr:CAB14885" /db_xref="GOA:O34600" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="PDB:5IPP" /db_xref="PDB:5IUF" /db_xref="PDB:5IZO" /db_xref="PDB:5J21" /db_xref="SubtiList:BG13910" /db_xref="UniProtKB/Swiss-Prot:O34600" /translation="MKTELIRTISLYDTIILHRHVRPDPDAYGSQCGLTEILRETYPE KNIFAVGTPEPSLSFLYSLDEVDNETYEGALVIVCDTANQERIDDQRYPSGAKLMKID HHPNEDPYGDLLWVDTSASSVSEMIYELYLEGKEHGWKLNTKAAELIYAGIVGDTGRF LFPNTTEKTLKYAGELIQYPFSSSELFNQLYETKLNVVKLNGFIFQNVSLSENGAASV FIKKDTLEKFGTTASEASQLVGTLGNISGIRAWVFFVEEDDQIRVRFRSKGPVINGLA RKYNGGGHPLASGASIYSWDEADRILADLETLCKEHE*" gene complement(2816415..2817356) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" S_feature 2816418..2816789 /Source="Nicolas_S_feature" /locus_tag="new_2995911_2996282" /HighExp="Lbstat, S2, M0t90, M40t90, nit, ferm, S3, BT, M9-stat, S0" /AntisenseName="nrnA" /AntisenseCor="-0.77648424268923499" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1110" downshifts complement(2816450) /Source="Nicolas_upshifts" /id="D1502" /incds=0 /nref=25 /ntot=163 /MaxReadThrough="3.12169" /MaxDrop="3.09205" /score="22.5196409" /energy="-7.9" /TU="U2268" /idTUdmin="U2269" /TUdmin="-1" /isTUend="TRUE" promotor_-35 2816758..2816767 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2816781..2816800 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2816791..2817185 /Source="Nicolas_S_feature" /locus_tag="new_2996284_2996678" /HighExp="Lbstat, S2, S7, S8, S6, nit, ferm, M0t90, BT, M40t90" /AntisenseName="nrnA" /AntisenseCor="-0.85531073541330804" /AntisenseRegPval="-77.5" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1111" upshifts 2816791 /Source="Nicolas_upshifts" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" promotor_-35 2817147..2817153 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2817169..2817188 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2817187..2817486 /Source="Nicolas_S_feature" /locus_tag="new_2996680_2996979" /HighExp="Lbstat, S8, S7, S6, S2, Etha, nit, ferm, BT, M0t90" /AntisenseName="nrnA" /AntisenseCor="-0.84034645112995598" /AntisenseRegPval="-72.2" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1112" upshifts 2817187 /Source="Nicolas_upshifts" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" promotor_-10 complement(2817375..2817394) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2817391) /Source="Nicolas_upshifts" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" S_feature complement(2817393..2817807) /Source="Nicolas_S_feature" /locus_tag="new_2996886_2997300_c" /HighExp="LBGtran, HiTm, G180, G135, G150, Lbtran, LBGexp, Mt0, Paraq, dia0" /AntisenseName="ytpI" /AntisenseCor="-0.70134306018551296" /AntisenseRegPval="-40.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1113" promotor_-35 complement(2817409..2817412) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2817487..2817789 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390804.1" /db_xref="EnsemblGenomes-Gn:BSU29260" /db_xref="EnsemblGenomes-Tr:CAB14886" /db_xref="GOA:O34922" /db_xref="InterPro:IPR025618" /db_xref="SubtiList:BG13902" /db_xref="UniProtKB/Swiss-Prot:O34922" /translation="MLVLVFLIGLSACFYVYYKVKGVRAKPSLAKEICSAKSSMALGS LVLFYGLNQMILFHSVLTLVIGGIFIVIGAGSAWAGYKAFRHYNPLHAKEAERDHA*" gene 2817487..2817789 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" S_feature 2817790..2819585 /Source="Nicolas_S_feature" /locus_tag="new_2997283_2999078" /HighExp="S8, S6, S7, Lbstat, B36, nit, ferm, T1.0H, C30, S5" /AntisenseName="ytoI" /AntisenseCor="-0.55304378374907204" /AntisenseRegPval="-22.2" /CDS_PredictionProba="0.89152299999999995" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1114" CDS complement(2817808..2819127) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26296725" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390805.1" /db_xref="EnsemblGenomes-Gn:BSU29270" /db_xref="EnsemblGenomes-Tr:CAB14887" /db_xref="GOA:O34921" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR010766" /db_xref="InterPro:IPR028979" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13897" /db_xref="UniProtKB/Swiss-Prot:O34921" /translation="MATKHEQILTYIDSLPVGEKISVRRIAKEMKVSEGTAYRAIKEA ENKGFVSTIERVGTIRIEQKKKENIEKLTYAEVVNVIDGQVLGGRAGLHKTLNKFVIG AMELDAMMRYTAAGNLLIVGNRINAHRQALEAGAAVLVTGGFNTDDSIVQLADELELP ILSTSYDTFTVAAMINRAIYDQLIKKEIVLVEDILTPADRTVYLSPKDKLEKWYEKNF ETGHGRFPVVDDQMKIHGILTSKDIAGHDRNASIEKVMTKNPVTVIGKTSVASAAQMM VWEGIEVLPVTDGHQKLIGMISRQDVLKALQMIQKQPQVGEKLDDIVSRGFKDEGDDK EDQTVYEYEVTPQMTNQLGTISYGVFTTILTQAANRFLRSKKRGELVIESITIFFLKP VQMESVIEVKPRILEAGRKFGKMEVEVHSQGHIVSKAMLMVQLMERS*" gene complement(2817808..2819127) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" promotor_-10 complement(2819153..2819172) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2819174) /Source="Nicolas_upshifts" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" promotor_-35 complement(2819187..2819192) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2819303..2820205) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390806.1" /db_xref="EnsemblGenomes-Gn:BSU29280" /db_xref="EnsemblGenomes-Tr:CAB14888" /db_xref="GOA:O34430" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13894" /db_xref="UniProtKB/Swiss-Prot:O34430" /translation="MKKLIVFAFIGLLSQLIDGSLGMAYGVTSTSLLLAFGITPAVAS ASVHLAEVVTTAASGVSHIKFGNVDKQTVYQLVIPGSIGAFLGAAFLSQLPGDVAKPY ISLFLLLLGGYVLIRFLFQYKPALEKKHVPLNRKQSIPLGVIAGFADATGGGGWGPVT TPILLSRKGLSPRKVVGTVDTSEFAIAVSATAGFLISLGWEDVNWLWVFSLMAGGIIA APIAAWLVQKFHPQLMGVLVGGFIILVNARTLINEWIANTAVHPLIYTAIGAIWLSAV LFVLSKIGNRNIVKTAVDVHLKEK*" gene complement(2819303..2820205) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" CDS complement(2820224..2821474) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10588044, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10588044, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-alkyl-N-acetyl-metabolite deacetylase" /protein_id="NP_390807.1" /db_xref="EnsemblGenomes-Gn:BSU29290" /db_xref="EnsemblGenomes-Tr:CAB14889" /db_xref="GOA:O34980" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR033846" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12596" /db_xref="UniProtKB/Swiss-Prot:O34980" /translation="MSLDYWRNIEGSYPYQTTGNDILTLKEESNPVNLSTLEKQLIGI RRHLHQYPELSKEEFETTAFIKKCLKEKGIQIRPTALKTGVFADIAGESEGPAIALRA DIDALPIEEKTGLPYASKHKGIMHACGHDFHTAALLGAAFLLKENQDSLKGKIRLLFQ PAEEAGAGATKVIEDGQLDGIDAVIGLHNKPDIAVGTVGLKTGPLMAAVDRFKVEIEG KGAHAALPHNGFDPIIGASQLIVALQTIVSRNVNPLQSAILTVGKINGGSTWNVIPDT VVIEGTVRTFDSEVRNQVKQRFFAVTEQISAAFSLKANVKWHSGPPPLCNDEAITGLV RDAAHKAKLQVIDPAPSTAGEDFAYYLEHIPGSFAFFGTDGDHDWHHPAFTIDETAII KASYFLYESAKRLLDSNEESKISD*" gene complement(2820224..2821474) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" CDS complement(2821492..2822184) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FMN-riboswitch-binding activator of rib genes" /protein_id="NP_390808.1" /db_xref="EnsemblGenomes-Gn:BSU29300" /db_xref="EnsemblGenomes-Tr:CAB14890" /db_xref="GOA:P94465" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11969" /db_xref="UniProtKB/Swiss-Prot:P94465" /translation="MTIIAGTVVKGKQLGRKLGFPTANVDAKIHGLRNGVYGVLATVN HQFHLGVMNIGVKPTVGSNLEKTLEIFLFDFHRDIYGEKIECSILFKIREERRFDSLE SLTKQIKKDISCVAKRFELIGIMAPNKKESLLSHQELNLPDLCFYKKCNNLYGVNRGV YNVIDNWFFEYGITQVAYRRIYILSFLSFLKEDNPKVSSKYIRFGAGGLADKLNRFIS SYVEESEENILG*" gene complement(2821492..2822184) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" CDS complement(2822231..2823559) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390809.1" /db_xref="EnsemblGenomes-Gn:BSU29310" /db_xref="EnsemblGenomes-Tr:CAB14891" /db_xref="GOA:O34974" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR016215" /db_xref="InterPro:IPR036661" /db_xref="PDB:1TVL" /db_xref="PDB:1YW1" /db_xref="SubtiList:BG13893" /db_xref="UniProtKB/Swiss-Prot:O34974" /translation="MTRADFIQFGAMIHGVGGTTDGWRHPDVDPSASTNIEFYMKKAQ TAEKGLFSFIFIADGLFISEKSIPHFLNRFEPITILSALASVTKNIGLVGTFSTSFTE PFTISRQLMSLDHISGGRAGWNLVTSPQEGAARNHSKSNLPEHTERYEIAQEHLDVVR GLWNSWEHDAFIHNKKTGQFFDQAKLHRLNHKGKYFQVEGPLNIGRSKQGEPVVFQAG SSETGRQFAAKNADAIFTHSNSLEETKAFYADVKSRAADEGRDPSSVRIFPGISPIVA DTEEEAEKKYREFAELIPIENAVTYLARFFDDYDLSVYPLDEPFPDIGDVGKNAFQST TDRIKREAKARNLTLREVAQEMAFPRTLFIGTPERVASLIETWFNAEAADGFIVGSDI PGTLDAFVEKVIPILQERGLYRQDYRGGTLRENLGLGIPQHQSVLHSSHH*" gene complement(2822231..2823559) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" CDS complement(2823556..2823837) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redoxin" /protein_id="NP_390810.1" /db_xref="EnsemblGenomes-Gn:BSU29320" /db_xref="EnsemblGenomes-Tr:CAB14892" /db_xref="GOA:O34639" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13892" /db_xref="UniProtKB/Swiss-Prot:O34639" /translation="MSDVVNIVVWSKKGCSYCEEVKNYLNEKGFPFQNIDVSEKEKLR DILQVKYGVRHVPVVEIGRGNQYQGITEIGIEHLDLALANHAQIKEAKR*" gene complement(2823556..2823837) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" CDS complement(2823852..2824856) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9836433, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9836433, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390811.1" /db_xref="EnsemblGenomes-Gn:BSU29330" /db_xref="EnsemblGenomes-Tr:CAB14893" /db_xref="GOA:O34846" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG13888" /db_xref="UniProtKB/Swiss-Prot:O34846" /translation="MIRLSILDQSLIGEGETAADTLQHTVKLAQMAEECGYHRFWVAE HHNNDEIAGSAPEVLLGYLAASTRKIRLASGGVMLQHYSSYKVAEQFHLLSALAPGRI DLGVGKAPGGFQLSTDALQAEYKKPVRQFDEKLEELTHFVRDDFPDTHRYAALRPRPQ VDRKPGIFLLGGSTESAISAAKLGISFVFAYFINGEEEVLKEARRAFDAHLPPGSEAE FHLAPAVFAAHTKEEAEKHIVSRESIKVVLKDGRKVNVGSREQAEAYLENVTEPYDII VQKTGIIAGTKEEVAEELTRLSGTYKINDFVIFTPIKNAVEKQLSYQLLSDAVLAAKR *" gene complement(2823852..2824856) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" CDS complement(2824853..2825632) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino-acid ABC transporter (ATP-binding protein)" /protein_id="NP_390812.1" /db_xref="EnsemblGenomes-Gn:BSU29340" /db_xref="EnsemblGenomes-Tr:CAB14894" /db_xref="GOA:O34900" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG12604" /db_xref="UniProtKB/Swiss-Prot:O34900" /translation="MIEIKNIHKQFGIHHVLKGINLTVRKGEVVTIIGPSGSGKTTFL RCLNLLERPDEGIISIHDKVINCRFPSKKEVHWLRKQTAMVFQQYHLFAHKTVIENVM EGLTIARKMRKQDAYAVAENELRKVGLQDKLNAYPSQLSGGQKQRVGIARALAIHPDV LLFDEPTAALDPELVGEVLEVMLEIVKTGATMIVVTHEMEFARRVSDQVVFMDEGVIV EQGTPEEVFRHTKKDRTRQFLRRVSPEYLFEPKEHIKEPVI*" gene complement(2824853..2825632) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" CDS complement(2825629..2826336) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390813.1" /db_xref="EnsemblGenomes-Gn:BSU29350" /db_xref="EnsemblGenomes-Tr:CAB14895" /db_xref="GOA:O34931" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13887" /db_xref="UniProtKB/Swiss-Prot:O34931" /translation="MQFDFPFIVSAMKEMVKTIPLTLMMAVLPIVFGFLVALGNIIVR IFRIKGLVACSRFYVSFFRSTPAILHIMLIYLGIPPVADQVSSFFHLGWSANEIPVSM FVIMALSLTAGAYLTEIIRSGILAMDTGQVEAAYSIGLTYSQTFRRVILPQALKVSIP NFTNLGIGFLHTTSIAAIVAVPEITGTATIVASDNYAFLEAFIGAAIIYWVLTLILES ANGVLERKAARFQGGTL*" gene complement(2825629..2826336) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" CDS complement(2826366..2827085) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390814.1" /db_xref="EnsemblGenomes-Gn:BSU29360" /db_xref="EnsemblGenomes-Tr:CAB14896" /db_xref="GOA:O34315" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13886" /db_xref="UniProtKB/Swiss-Prot:O34315" /translation="MEKAFDMNMIGDFVPTLTAYLPVTLYILTLSLLFGFVLGLFLAL PRIYNIPIVNQLAKVYISFFRGTPIMVQLFIVFYGIPALTGLIGIDTSKMDPFYAAVA TYALSNAAAAAEIIRAGVGSVDKGQTEAAYSIGLSGSQAFRRIVLPQALVQAFPNMGN MVISSLKDTSLAFSIGVMDMSGRGQTLITSSNHSLEVYIALSIVYYAVAVLFEWFFRV AEKRIKKNQTRIVTVFDMNIH*" gene complement(2826366..2827085) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" promotor_-35 2826911..2826918 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2826933..2826952 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2826933 /Source="Nicolas_upshifts" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2827107..2827919) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 22720735, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 22720735, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390815.1" /db_xref="EnsemblGenomes-Gn:BSU29370" /db_xref="EnsemblGenomes-Tr:CAB14897" /db_xref="GOA:O34852" /db_xref="InterPro:IPR001638" /db_xref="PDB:2O1M" /db_xref="SubtiList:BG13885" /db_xref="UniProtKB/Swiss-Prot:O34852" /translation="MKTKTAFMAILFSLITVLSACGAGSQTTGAGQKKVQTITVGTGT QFPNICFIDEKGDLTGYDVELIKELDKRLPHYKFTFKTMEFSNLLVSLGQHKVDIVAH QMEKSKEREKKFLFNKVAYNHFPLKITVLQNNDTIRGIEDLKGKRVITSATSNGALVL KKWNEDNGRPFEIAYEGQGANETANQLKSGRADATISTPFAVDFQNKTSTIKEKTVGN VLSNAKVYFMFNKNEQTLSDDIDKALQEIIDDGTLKRLSLKWLGDDYSKEQY*" gene complement(2827107..2827919) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" CDS complement(2827933..2828742) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390816.1" /db_xref="EnsemblGenomes-Gn:BSU29380" /db_xref="EnsemblGenomes-Tr:CAB14898" /db_xref="GOA:O34406" /db_xref="InterPro:IPR001638" /db_xref="SubtiList:BG13884" /db_xref="UniProtKB/Swiss-Prot:O34406" /translation="MNKRKGLVLLLSVFALLGGGCSQTNNKTDRQAQTVIVGTGTDFP NIAFLNEKGELTGYDIEVMKAIDKELPQYTFEFKTMDFSNLLTSLGNKKIDVIAHNMA KNKEREKRFLYHKVPYNYSPMYITVKEDNHKIHTLKDLHGKTVIVGATSNAADYITKY NKTHGSPIHLKYAGQGSNDTANQIETGRADATIATPFAVDFQNKTHAFRQKTVGDVLL DTEVYFMFNKGSQTLADDTDQAIKKLEKNGTLKKLSRKWLGADYSKSSFEK*" gene complement(2827933..2828742) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" CDS complement(2828756..2829292) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyltransferase acting on sulfur compounds" /protein_id="NP_390817.1" /db_xref="EnsemblGenomes-Gn:BSU29390" /db_xref="EnsemblGenomes-Tr:CAB14899" /db_xref="GOA:O34350" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13883" /db_xref="UniProtKB/Swiss-Prot:O34350" /translation="MSDDIFRLATVEDASELLKLVNSAFQPIRQLDIDWPSTRADIQM VSENIEHHSAIVLERDGKLISTITIRFPWESETPPSKYPFVWWFATLPEYKGQGAGSK LLTYVEEKVLRDMLKAPALTLGTSARKHPWLADMYRRRGYEVYFEQEKDGDIGVMMHK VLIPERFNPTLLGAPSWA*" gene complement(2828756..2829292) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" promotor_-35 2829329..2829336 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2829347..2829366) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2829350..2829369 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2829353..2829444 /Source="Nicolas_S_feature" /locus_tag="new_3008846_3008937" /HighExp="dia5, MG 5, UNK1, MG t5, MG 10, B60, dia0, nit, Diami, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1115" upshifts 2829353 /Source="Nicolas_upshifts" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" upshifts complement(2829363) /Source="Nicolas_upshifts" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" promotor_-35 complement(2829380..2829387) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2829445..2830371 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of operon snaA-ytnM degrading cysteine-containing compounds (AscR-N-acetylcysteine)" /protein_id="NP_390818.1" /db_xref="EnsemblGenomes-Gn:BSU29400" /db_xref="EnsemblGenomes-Tr:CAB14900" /db_xref="GOA:O35038" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13877" /db_xref="UniProtKB/Swiss-Prot:O35038" /translation="MELRSIKTFHTIVKFGSFYKAAEILNYSQPTISMRMKQLEQDLG VLLFERGKSLQLTKAGKLFYERTGDLLMQYEALKHNLSDLKEEEAGIINIGVSEPTAS LIFPEILKDFLMDYPKITVNIKVDDANTCSQKLLDGTIDFAVCGEPELILENYYHPFF YDTLNVIVSDQHPLAEKKAVHLSDLAEERFIFTPANCPIRLQIEQHLHRELGNRYKKM ELTSSMSHEYYVRENIGISIFTSTAHSKPFNGTKVIPILNLDITPPIGLLTNQKEVHF DRATKDLIARITKRFQQRSKELEGTSDKTITG*" gene 2829445..2830371 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" S_feature complement(2829847..2830376) /Source="Nicolas_S_feature" /locus_tag="new_3009340_3009869_c" /HighExp="Etha, dia15, dia5, H2O2, M9-stat, M40t90, Sw, Gly, M0t90, Cold" /AntisenseName="ytlI" /AntisenseCor="-7.8012588423369304E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1116" downshifts complement(2830421) /Source="Nicolas_upshifts" /id="D1503" /incds=0 /nref=142 /ntot=251 /MaxReadThrough="4.32965" /MaxDrop="5.01142" /score="39.1547987" /energy="-16.5" /TU="U2273" /idTUdmin="U2274" /TUdmin=20 /isTUend="TRUE" CDS complement(2830422..2831105) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390819.2" /db_xref="EnsemblGenomes-Gn:BSU29410" /db_xref="EnsemblGenomes-Tr:CAB14901" /db_xref="GOA:Q795U4" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR022877" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13871" /db_xref="UniProtKB/Swiss-Prot:Q795U4" /translation="MKVTYHGHSVITVETKDHHIIFDPFLTGNSLTDIKPEDVKADVI LLTHGHNDHVGDTEQIAKQNNALVIAPNELAVYLGWKGLNVHPMHIGGSRQFDFGKVK LTQAFHGSAITDEENKTITYTGMPAGILLTVEDKTIFHAGDTALFSDMKLIGELNHID LAFLPIGDNFTMGPEDAKLAAEWLRAKQVVPVHYNTFPVIEQDPEAFADSLPGGVGKV MSVGETIEL*" gene complement(2830422..2831105) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" S_feature complement(2831106..2831167) /Source="Nicolas_S_feature" /locus_tag="new_3010599_3010660_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, M0t90, M40t90, Salt, LBGtran, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1117" CDS complement(2831168..2831935) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_390820.1" /db_xref="EnsemblGenomes-Gn:BSU29420" /db_xref="EnsemblGenomes-Tr:CAB14902" /db_xref="GOA:O34308" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13870" /db_xref="UniProtKB/Swiss-Prot:O34308" /translation="MRHALITAGSKGLGRKVTETLLAKGYSVTVNYRQDEEAVSRLKE ACPDCLDRLQFVKGDVTKKEDLLRIAEAALNRFGRIDFLINNAGPYIFERKKLADYTD DEWYGMLEGNLSAVFHLFKAVIPIMRKQQFGRIITYGFQGAAHAPGWLHRSAFGAAKV GLASLTKTIAIEEAEFGITANMVCPGDIVGDMKEASIEEARMRIGKEKTPIGRSGTGE DIARIIAFLCEENSDLVTGTVIEATGGLNVINKNQTT*" gene complement(2831168..2831935) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" promotor_-10 complement(2831980..2831999) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2832002) /Source="Nicolas_upshifts" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" promotor_-35 complement(2832015..2832017) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2832062..2832298) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11423008" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390821.3" /db_xref="EnsemblGenomes-Gn:BSU29430" /db_xref="EnsemblGenomes-Tr:CAB14903" /db_xref="SubtiList:BG13938" /db_xref="UniProtKB/Swiss-Prot:O34503" /translation="MKKRKLAWQQEFVKISFIKSRHYSQPTSIMMGGRMMKKEPERYI YDEQESQETTRLISEAYQSGYVDMPDQESSSPAE*" gene complement(2832062..2832298) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" downshifts 2832147 /Source="Nicolas_upshifts" /id="D1504" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="0.55049" /MaxDrop="4.17437" /score="-5.88070891" /energy="-8.9" /TU="NA" /idTUdmin="U2271" /TUdmin=1782 /isTUend="FALSE" downshifts complement(2832167) /Source="Nicolas_upshifts" /id="D1505" /incds=0 /nref=199 /ntot=288 /MaxReadThrough="5.44889" /MaxDrop="6.29233" /score="21.2322542" /energy="-8.5" /TU="U2274" /idTUdmin="U2274" /TUdmin="-1726" /isTUend="FALSE" CDS complement(2832258..2833643) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" /EC_number="4.3.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 9890879, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 9890879, 11423008; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate lyase" /protein_id="NP_390822.1" /db_xref="EnsemblGenomes-Gn:BSU29440" /db_xref="EnsemblGenomes-Tr:CAB14904" /db_xref="GOA:O34858" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR009049" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="InterPro:IPR029419" /db_xref="SubtiList:BG12571" /db_xref="UniProtKB/Swiss-Prot:O34858" /translation="MKKLWGGRFQKTPEKWVDEFGASISFDQNLVAEDITGSLAHAAM LKKCGILTAEEELKIREGLNTLLQKAEEGALEFSVDYEDIHLNIEKMLIDEIGPLGGK LHTGRSRNDQVATDMHLYLKNHVGHIIELIEAFQSALIEKAEANVETILPGYTHLQRA QPISFAHHLLAYFWMLERDKERFQDSMKRINKSPLGCGALAGTTFPIDRDYSAELLGF DAIYENSLDGVSDRDFILEFLSNSSMLMMHLSRFSEEIILWCSQEFKFIELDDTYATG SSMMPQKKNPDMAELIRGKTGRVYGDMMGLFTIMKGLPLAYNKDLQEDKEGMFDTVKT VEGSLQIFTGMIQTMTVNKDVMKQATKQDFSNATELADYLAKKGMPFREAHEVVGKLV YTCIERGIYLSDMPFGEFQQASTLFEEDIYTVLDPYYAVEKRMSAGGTGFKQVEQALE KAKACVAAGVC*" gene complement(2832258..2833643) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" CDS complement(2833640..2834851) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" /EC_number="6.3.4.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 11423008, 12963366, 17611193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 11423008, 12963366, 17611193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate synthase" /protein_id="NP_390823.1" /db_xref="EnsemblGenomes-Gn:BSU29450" /db_xref="EnsemblGenomes-Tr:CAB14905" /db_xref="GOA:O34347" /db_xref="InterPro:IPR001518" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018223" /db_xref="InterPro:IPR023434" /db_xref="InterPro:IPR024074" /db_xref="SubtiList:BG12570" /db_xref="UniProtKB/Swiss-Prot:O34347" /translation="MSEQKKVVLAYSGGLDTSVAIKWLQEQGYNVIACCLDVGEGKDL AFVQQKALEVGATNSYVIDAKEEFAQDYALISLQAHTMYEGKYPLVSALSRPLIAKKL VEIAEKEDAQAIAHGCTGKGNDQVRFEVSIKSLNPDLEVIAPVREWQWSREEEIEYAA SRGIPIPINLDSPYSIDQNLWGRANECGILEDPWAAPPEGAYDLTAPLEKTPDTPEVI EIAFEQGVPVSIDGVSYSLSELILKLNEMAGAHGVGRIDHVENRLVGIKSREVYECPG AMTLIKAHKELEDLTLVKEVAHFKPIIEQKMSEIIYNGLWFSPLKDALHAFLKETQKH VTGIVRVKLFKGHAIVEGRKSEYSLYDEKLATYTKDDAFDHHAAIGFIELWGLPTKVN SIVKKKEQIKA*" gene complement(2833640..2834851) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" S_feature complement(2834852..2834929) /Source="Nicolas_S_feature" /locus_tag="new_3014345_3014422_c" /HighExp="S1, MG 15, T3.0H, T3.30H, T4.0H, T5.0H, BMM, T2.30H, T-0.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1118" promotor_-10 complement(2834922..2834941) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2834928) /Source="Nicolas_upshifts" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" promotor_-35 complement(2834956..2834963) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2835021..2835533) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15269205, 20054111, 23680484; Product type f: factor" /codon_start=1 /transl_table=11 /product="molybdopterin GTP-binding precursor Z biosynthesis component" /protein_id="NP_390824.1" /db_xref="EnsemblGenomes-Gn:BSU29460" /db_xref="EnsemblGenomes-Tr:CAB14924" /db_xref="GOA:O34457" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008284" /db_xref="InterPro:IPR012245" /db_xref="InterPro:IPR036425" /db_xref="SubtiList:BG12618" /db_xref="UniProtKB/Swiss-Prot:O34457" /translation="MSVQEHKQEAPDIVRCKVITVSDTRTDETDKSGKLMISFLEEAG HHIAAYEIVKDEKDALQRSVLAGCMDEQTDAVLLNGGTGIADRDVTIEAITPLFSKEL PGFGEIFRMLSYTEDIGSAAIMSRATAGVIQHTAVFSTPGSSGAVKLAMNKLIIPELA HVVREIRKDK*" gene complement(2835021..2835533) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" downshifts complement(2835039) /Source="Nicolas_upshifts" /id="D1506" /incds=0 /nref=122 /ntot=221 /MaxReadThrough="1.48097" /MaxDrop="4.78155" /score="25.7910606" /energy="-10.8" /TU="NA" /idTUdmin="U2275" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2835559..2835578) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2835567) /Source="Nicolas_upshifts" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" promotor_-35 complement(2835592..2835599) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2835618..2836805) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" /EC_number="2.7.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8226682, 9811655, 11244084, 16995897, 19019159, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226682, 9811655, 11244084, 16995897, 19019159, 26098117; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetate kinase" /protein_id="NP_390825.1" /db_xref="EnsemblGenomes-Gn:BSU29470" /db_xref="EnsemblGenomes-Tr:CAB14925" /db_xref="GOA:P37877" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR004372" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG10813" /db_xref="UniProtKB/Swiss-Prot:P37877" /translation="MSKIIAINAGSSSLKFQLFEMPSETVLTKGLVERIGIADSVFTI SVNGEKNTEVTDIPDHAVAVKMLLNKLTEFGIIKDLNEIDGIGHRVVHGGEKFSDSVL LTDETIKEIEDISELAPLHNPANIVGIKAFKEVLPNVPAVAVFDTAFHQTMPEQSYLY SLPYEYYEKFGIRKYGFHGTSHKYVTERAAELLGRPLKDLRLISCHLGNGASIAAVEG GKSIDTSMGFTPLAGVAMGTRSGNIDPALIPYIMEKTGQTADEVLNTLNKKSGLLGIS GFSSDLRDIVEATKEGNERAETALEVFASRIHKYIGSYAARMSGVDAIIFTAGIGENS VEVRERVLRGLEFMGVYWDPALNNVRGEEAFISYPHSPVKVMIIPTDEEVMIARDVVR LAK*" gene complement(2835618..2836805) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" downshifts complement(2835633) /Source="Nicolas_upshifts" /id="D1507" /incds=0 /nref=13 /ntot=117 /MaxReadThrough="5.03131" /MaxDrop="3.1641" /score="19.2403206" /energy="-9.9" /TU="U2276" /idTUdmin="U2277" /TUdmin=242 /isTUend="FALSE" S_feature complement(2836806..2836910) /Source="Nicolas_S_feature" /locus_tag="new_3016299_3016403_c" /HighExp="dia0, Lbexp, LBGtran, Oxctl, LPh, M0t45, HPh, Paraq, H2O2, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1119" promotor_-10 complement(2836895..2836914) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2836910) /Source="Nicolas_upshifts" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" S_feature complement(2836912..2837041) /Source="Nicolas_S_feature" /locus_tag="new_3016405_3016534_c" /HighExp="S5, S6, S7, S8, S4, dia5, BT, H2O2, dia15, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1120" promotor_-35 complement(2836930..2836934) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2836978..2837181) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513997.1" /translation="MMNGLKKKSKCFKSSLDSRMRSMPKLLLFMLLKTGLDELNPALK HKIQREKPQIVSVHQYKTYSECV*" gene complement(2836978..2837181) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" promotor_-10 complement(2837039..2837050) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2837041) /Source="Nicolas_upshifts" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" promotor_-35 complement(2837065..2837071) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2837153..2838142) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid methyltransferase" /protein_id="NP_390826.1" /db_xref="EnsemblGenomes-Gn:BSU29480" /db_xref="EnsemblGenomes-Tr:CAB14926" /db_xref="GOA:P37876" /db_xref="InterPro:IPR003356" /db_xref="InterPro:IPR016843" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10812" /db_xref="UniProtKB/Swiss-Prot:P37876" /translation="MQKDHVGAVYELLNEAAIMIKNELQISYIEALAEAGEMYFLEKT DQLKLPADQKTKQLQALLEKAEFGTYEHEWVRKAFQLAVLKGMKDISHPNRQMTPDTI GLFISYLVNKFMADKKELTILDPALGTGNLLFTVLNQLSEKTANSFGIEIDDVLLKIA YAQANLLKKELELFHQDSLEPLFIDPVDTVICDLPVGYYPNDEGAEAFELKADEGHSF AHHLFIEQSVKHTKPGGYLFFMIPNHLFESSQSGKLKQFFKDKVHINALLQLPKSIFK DEAHAKSILVLQKQGENTKAPGQILLANLPSFSNQKAMLDMMAQFDEWFKKEK*" gene complement(2837153..2838142) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" downshifts complement(2837171) /Source="Nicolas_upshifts" /id="D1508" /incds=0 /nref=158 /ntot=243 /MaxReadThrough="3.51469" /MaxDrop="5.25938" /score="-4.33730173" /energy="-13.3" /TU="NA" /idTUdmin="U2279" /TUdmin="-20" /isTUend="TRUE" CDS complement(2838203..2838706) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486061, 18588855, 18588855, 23899494, 25355936, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486061, 18588855, 18588855, 23899494, 25355936, 25852656; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol peroxidase (lipid hydroperoxide reductase)" /protein_id="NP_390827.1" /db_xref="EnsemblGenomes-Gn:BSU29490" /db_xref="EnsemblGenomes-Tr:CAB14927" /db_xref="GOA:P80864" /db_xref="InterPro:IPR002065" /db_xref="InterPro:IPR013740" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR018219" /db_xref="InterPro:IPR036249" /db_xref="PDB:2JSY" /db_xref="PDB:2JSZ" /db_xref="SubtiList:BG13855" /db_xref="UniProtKB/Swiss-Prot:P80864" /translation="MAEITFKGGPVTLVGQEVKVGDQAPDFTVLTNSLEEKSLADMKG KVTIISVIPSIDTGVCDAQTRRFNEEAAKLGDVNVYTISADLPFAQARWCGANGIDKV ETLSDHRDMSFGEAFGVYIKELRLLARSVFVLDENGKVVYAEYVSEATNHPNYEKPIE AAKALVK*" gene complement(2838203..2838706) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" downshifts complement(2838209) /Source="Nicolas_upshifts" /id="D1509" /incds=0 /nref=53 /ntot=241 /MaxReadThrough="6.94509" /MaxDrop="4.3179" /score="9.29337297" /energy="-10.1" /TU="U2279" /idTUdmin="U2280" /TUdmin=548 /isTUend="FALSE" promotor_no_box 2838423..2838523 /Source="Nicolas_upshift_promotors" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2838483 /Source="Nicolas_upshifts" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2838702 /Source="Nicolas_upshifts" /id="D1510" /incds=0 /nref=86 /ntot=184 /MaxReadThrough="2.23568" /MaxDrop="5.49495" /score="20.1242958" /energy="-12.7" /TU="NA" /idTUdmin="U2278" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(2838729..2838748) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2838745) /Source="Nicolas_upshifts" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" promotor_-35 complement(2838762..2838769) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2838816..2839271) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" /experiment="publication(s) with functional evidences, PMID:23921501, 25790435, 27881417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23921501, 25790435, 27881417; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination-associated protein" /protein_id="NP_390828.1" /db_xref="EnsemblGenomes-Gn:BSU29500" /db_xref="EnsemblGenomes-Tr:CAB14928" /db_xref="GOA:O34806" /db_xref="InterPro:IPR014229" /db_xref="SubtiList:BG13849" /db_xref="UniProtKB/Swiss-Prot:O34806" /translation="MADHPIQGLMKTAMENLKEMIDVNTIIGDPVETPDGSVILTVSK VGFGFAAGGSEFGGKPAEKKSEDDETREQKLPFGGGSGGGVSITPIAFLIVGSTGIRM LHLDENTHLIEKILDAAPQTLERIQQMFKKNNKNQSQGQNQNQMNNMNY*" gene complement(2838816..2839271) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" downshifts complement(2838844) /Source="Nicolas_upshifts" /id="D1511" /incds=0 /nref=38 /ntot=91 /MaxReadThrough="3.69502" /MaxDrop="5.65648" /score="26.1939476" /energy="-12.7" /TU="U2280" /idTUdmin="U2280" /TUdmin="-87" /isTUend="FALSE" CDS complement(2839285..2839965) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390829.1" /db_xref="EnsemblGenomes-Gn:BSU29510" /db_xref="EnsemblGenomes-Tr:CAB14929" /db_xref="InterPro:IPR021338" /db_xref="SubtiList:BG13848" /db_xref="UniProtKB/Swiss-Prot:O34917" /translation="MVYVLTAILILIGIVLLLRMKIHVALEYLHADDNDKLTLKITAL FGLIRIKKTIPAIKVNKEDGTVDIKQKTESKMKKSSGKKKITQNDVQQSINKIEMLLH QVTRLRKISASFLAHLHITKLEWVTVIGIQDAAVTGVLTGAVWGVKGGIAAMLYDHLD FVNKPVYEVIPSFQVPVSKTHFQCIFFFRFGHAMLAAFKFVKYGRELSVLKKNPSARM TSKNDSSV*" gene complement(2839285..2839965) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" upshifts complement(2839377) /Source="Nicolas_upshifts" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" promotor_-10 complement(2839384..2839395) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-10" promotor_-35 complement(2839410..2839416) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-35" downshifts complement(2839703) /Source="Nicolas_upshifts" /id="D1512" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.64036" /MaxDrop="2.98792" /score="28.0381876" /energy="-11.8" /TU="U2281" /idTUdmin="U2281" /TUdmin="-308" /isTUend="FALSE" promotor_-10 complement(2839978..2839996) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-10" upshifts complement(2839992) /Source="Nicolas_upshifts" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" promotor_-35 complement(2840011..2840016) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-35" CDS complement(2840040..2840534) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390830.1" /db_xref="EnsemblGenomes-Gn:BSU29520" /db_xref="EnsemblGenomes-Tr:CAB14930" /db_xref="GOA:O34424" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG13840" /db_xref="UniProtKB/Swiss-Prot:O34424" /translation="MDATYEELERNDIKGPQEAELLTHAYAGFWVRFWAFLLDWLVIW GLNHLLVSPLFTVLDLPKTSGMFTFSAYSVTTLIVYLAYFALMTKYFRQTLGKMVFGL KVVSVKQDSKLTWSTVIFREVVGRYIDKIWILYIVVAFSPTKQGIHDYIADTTVVHEK LYRK*" gene complement(2840040..2840534) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" downshifts complement(2840055) /Source="Nicolas_upshifts" /id="D1513" /incds=0 /nref=240 /ntot=258 /MaxReadThrough="1.43721" /MaxDrop="6.8315" /score="28.0381876" /energy="-11.8" /TU="NA" /idTUdmin="U2282" /TUdmin=0 /isTUend="TRUE" CDS complement(2840547..2841554) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9987136, 10455123, 16484219, 22472423, 23155385, 24228759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 10455123, 16484219, 22472423, 23155385, 24228759; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="signal peptide peptidase" /protein_id="NP_390831.1" /db_xref="EnsemblGenomes-Gn:BSU29530" /db_xref="EnsemblGenomes-Tr:CAB14931" /db_xref="GOA:O34525" /db_xref="InterPro:IPR002142" /db_xref="InterPro:IPR004635" /db_xref="InterPro:IPR029045" /db_xref="PDB:3RST" /db_xref="PDB:4KWB" /db_xref="SubtiList:BG13839" /db_xref="UniProtKB/Swiss-Prot:O34525" /translation="MNAKRWIALVIALGIFGVSIIVSISMSFFESVKGAQTDLTSLTD ESQEKTLENGSPSSKIAVLEVSGTIQDNGDSSSLLGADGYNHRTFLKNLERAKDDKTV KGIVLKVNSPGGGVYESAEIHKKLEEIKKETKKPIYVSMGSMAASGGYYISTAADKIF ATPETLTGSLGVIMESVNYSKLADKLGISFETIKSGAHKDIMSPSREMTKEEKNIMQS MVDNSYEGFVDVISKGRGMPKAEVKKIADGRVYDGRQAKKLNLVDELGFYDDTITAMK KDHKDLKNASVISYEESFGLGSLFSMGANKMFKSEIDFLNMREILSQSGSPRMMYLYA K*" gene complement(2840547..2841554) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" promotor_-10 complement(2841578..2841593) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2841595) /Source="Nicolas_upshifts" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" S_feature complement(2841597..2841676) /Source="Nicolas_S_feature" /locus_tag="new_3021090_3021169_c" /HighExp="LBGexp, Oxctl, LBGtran, dia0, H2O2, dia15, G180, G150, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1121" promotor_-35 complement(2841605..2841614) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2841654..2841673 /Source="Nicolas_upshift_promotors" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2841664 /Source="Nicolas_upshifts" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" promotor_-10 complement(2841669..2841688) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2841673..2841739 /Source="Nicolas_S_feature" /locus_tag="new_3021166_3021232" /HighExp="M0t90, Sw, M9-stat, BC, M40t90, T4.0H, T2.30H, S1, T3.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1122" upshifts complement(2841676) /Source="Nicolas_upshifts" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" promotor_-35 complement(2841704..2841708) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2841740..2842543 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" /EC_number="2.7.1.23" /function="16.7: Manage energy" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897004, 16233726, 16511117, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase" /protein_id="NP_390832.1" /db_xref="EnsemblGenomes-Gn:BSU29540" /db_xref="EnsemblGenomes-Tr:CAB14932" /db_xref="GOA:O34934" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13837" /db_xref="UniProtKB/Swiss-Prot:O34934" /translation="MTDQRRNVYFFHKQDQETNEQARSLTQLAEEHGFTVVNQHSDAN IIASIGGDGTFLQAVRKTNFRDDCLYVGITKKGKAHLYCDFHSDEREKMVDAMTFEQI EVRKYPLIEVTVDQASPFHCLNEVSIRSSIIKTFVMDVLIDDLHFETFRGDGMIISTP TGSTAYNKSVAGAVVDPLLPCMQVSELASLNNNTYRTLGSPFVLSSDRKLTLRVVQDG NEHPIIGLDNEALSTRNVKTIEIKLSNKKIKTVKLKDNSFWEKVKRTFL*" gene 2841740..2842543 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" downshifts 2842473 /Source="Nicolas_upshifts" /id="D1514" /incds=1 /nref=46 /ntot=222 /MaxReadThrough="5.39036" /MaxDrop="3.90238" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-124" /isTUend="FALSE" downshifts 2842531 /Source="Nicolas_upshifts" /id="D1515" /incds=0 /nref=6 /ntot=54 /MaxReadThrough="3.14676" /MaxDrop="4.64552" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-66" /isTUend="FALSE" CDS complement(2842575..2844164) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19433221, 20386924, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-substituted formamide deformylase, dihydropyrimidinase or isoaspartyl peptidase" /protein_id="NP_390833.1" /db_xref="EnsemblGenomes-Gn:BSU29550" /db_xref="EnsemblGenomes-Tr:CAB14933" /db_xref="GOA:O34355" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR013108" /db_xref="InterPro:IPR032466" /db_xref="InterPro:IPR033932" /db_xref="SubtiList:BG13835" /db_xref="UniProtKB/Swiss-Prot:O34355" /translation="MKAIWHGGFIYTMLEEGDRTEAVYVEDGVIKGTGSYERLKEKYG SPETEEISLNGAVMFPGFVDSHLHLIGHGEKQLQLDLSALTSKDSILQAAKERERQLP KNDWLIGEGWNENQFETPDYLTKHDLDRLFPDRPVLLKRICRHAIAVNSAALQAAGIS RNTPDPDGGVIVKDANGEPTGLLFDKAQDLILKAVPPVSQHYVDEALTAAIKDCWTKG LTGGHSEDLSYYGDVSVPMKAYEKAAAGGKYPFRCHLLVHHEAVDRWEQLEKLSGPYV EFGAMKIFADGALGGRTALLKEPYQDDPSTNGVQVHDDETLGRLIRKAREKGMEVAVH AIGDLAFEKVLNAIEKHPPKNGRHDRLIHAQVLDNELIERAARMPIALDLQPHFVASD FPWVIDRLGKDRMKTAFAWKTLISKGILCAGGSDAPIEPVDPLLGIQSAVLRKSSHEQ NGPSYNESECLPVYEAIKLYTEGSAGIIYKEKSRGKIAEGYDADFTVLSGDPFAIDPA QLHLLEIKKTVINGQIVYEKS*" gene complement(2842575..2844164) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" downshifts complement(2842584) /Source="Nicolas_upshifts" /id="D1516" /incds=0 /nref=149 /ntot=255 /MaxReadThrough="2.61299" /MaxDrop="5.92403" /score="32.0110789" /energy="-13.8" /TU="NA" /idTUdmin="U2285" /TUdmin=1 /isTUend="TRUE" CDS complement(2844184..2845773) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" /EC_number="6.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-coenzyme A synthetase" /protein_id="NP_390834.2" /db_xref="EnsemblGenomes-Gn:BSU29560" /db_xref="EnsemblGenomes-Tr:CAB14934" /db_xref="GOA:C0SPB0" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13834" /db_xref="UniProtKB/Swiss-Prot:C0SPB0" /translation="MLKREDLIAPVQYNLVNEMEKFSAAGQKTALLWEDESGKQESWS YEKLMEETNKIGAALADLGFKKGDKLIVMVPRVLEAYAVYLAILKSGMVVIPCSEMLR AKDLEYRIEHAEVKGAIVYSEFIGAFRDVSTADKLITLSIGENDAGWKNLLSIEADGS QFKTADTTRDDMAFLSYTSGTTGQPKGVVHTHGWAFAHLKTSAGAWLDISEKDIVWAT AAPGWQKWVWSPFLAVLGSGATGFVYHGRFKAEKYLELLNRYKINVFCCTPTEYRLMA KVEGLKRFDLSALHSAVSAGEPLNREVIDVFQKHFGIKVRDGYGQTESTLLVGVLKDT PIKPGSMGKPTPGNQVEIINEDGEICKPGEVGDIAVHLSTPALFKEYFKDPERMKTQI RGDYFLTGDRARKDEEGYFWFESRNDDIIISSGYTIGPFEVEDALVKHPEVKECAVVA SPDEIRGSIVKAYVVLQNHEKRSDELVKMLQNHVKTITAPYKYPREIEFVESLPKTAS AKIRRVELRKREEQLKANKKA*" gene complement(2844184..2845773) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" promotor_-10 complement(2845819..2845836) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2845824) /Source="Nicolas_upshifts" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" promotor_-35 complement(2845852..2845858) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2845951) /Source="Nicolas_upshifts" /id="D1517" /incds=0 /nref=242 /ntot=266 /MaxReadThrough="2.32229" /MaxDrop="9.17935" /score="30.5720337" /energy="-13.3" /TU="NA" /idTUdmin="U2287" /TUdmin=0 /isTUend="TRUE" CDS complement(2845952..2846161) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:2456528, 2468649, 3009398, 16707666" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2456528, 2468649, 3009398, 16707666; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha-type SASP)" /protein_id="NP_390835.1" /db_xref="EnsemblGenomes-Gn:BSU29570" /db_xref="EnsemblGenomes-Tr:CAB14935" /db_xref="GOA:P04831" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10786" /db_xref="UniProtKB/Swiss-Prot:P04831" /translation="MANNNSGNSNNLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRA NGSVGGEITKRLVSFAQQNMGGGQF*" gene complement(2845952..2846161) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" promotor_-35 2846157..2846161 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2846161 /Source="Nicolas_upshifts" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2846170..2846184 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2846182..2846193) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2846193) /Source="Nicolas_upshifts" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" promotor_-35 complement(2846208..2846214) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2846255..2847460) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" /EC_number="2.8.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14757766, 16343540, 22773787, 24705700, 28287455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14757766, 16343540, 22773787, 24705700, 28287455; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="persulfide ATP pyrophosphatase involved in tRNA modification" /protein_id="NP_390836.2" /db_xref="EnsemblGenomes-Gn:BSU29580" /db_xref="EnsemblGenomes-Tr:CAB14936" /db_xref="GOA:O34595" /db_xref="InterPro:IPR003720" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020536" /db_xref="SubtiList:BG13827" /db_xref="UniProtKB/Swiss-Prot:O34595" /translation="MNYDHILIRFGEISTKGKNRKSFIERLKQNIRLVLKDYPNLKYF SNRDRMTITLNGEDPEALFPHLKQVFGIQSFSLAIKCDSRLDDIKATALKAIKDQYKP GDTFKVATKRAYKQFELDTNQMNAEIGGHILRNTEGLTVDVRNPDIPLRIEIREEATF LTIRDEKGAGGLPVGSAGKAMLMLSGGFDSPVAGFYAMKRGLSVEAVHFFSPPYTSER AKQKVMDLAKCLSRFGGSMTLHIVPFTKTQELIQKQIPENYTMTATRRLMLQIADRIR EKRNGLAIITGESLGQVASQTLESMYAINAVTSTPILRPLIAMDKTEIIEKSREIGTY ETSIQPFEDCCTIFTPPSPKTRPKKEKIEHFESFVDFEPYIQEAVDNIETMTLYSEQE ANDKFAELF*" gene complement(2846255..2847460) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" CDS complement(2847464..2848609) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_390837.1" /db_xref="EnsemblGenomes-Gn:BSU29590" /db_xref="EnsemblGenomes-Tr:CAB14937" /db_xref="GOA:O34874" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="SubtiList:BG12632" /db_xref="UniProtKB/Swiss-Prot:O34874" /translation="MIYLDNSSTTKPYDEVLNVYEQTSSRYFGNPSSLHRYGAETEQL LQAAKNQIKRSLGLKKYDIVFTSGATEANNAALKGAALSKIKTGKHIIATSIEHPSVT ESLEQLKELFGFDITYLSVNEDGFVSIEDLKAAIRPDTVLVSMMHVNNEVGSVQPIEA AGEVLKEHSNILFHVDYVQGIYKVPLAIEKAGIDLCSISGHKFHGLKGTGALIVKEGT RLIPLITGGSQQKGIRAGTEHTAGAVSLAKAINLASADFDTRLDTMTAVKELFMNRLS EIEGVVINTPQMNSAPHIINFSVPGIKAEVLLHMLEEQDIFVSTTSACSAKEHKPSKV LLEMGKGEQIAGSSIRISLNYSQTSDVAEPFMNALRPGIKKLREMMR*" gene complement(2847464..2848609) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" S_feature complement(2848610..2849753) /Source="Nicolas_S_feature" /locus_tag="new_3028103_3029246_c" /HighExp="Diami, dia15, dia5, H2O2, G135, G180, G150, C30, Paraq, LBGstat" /AntisenseName="braB" /AntisenseCor="0.41502288403214899" /AntisenseRegPval="-11.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1123" promotor_-35 2848696..2848703 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2848714..2848803 /Source="Nicolas_S_feature" /locus_tag="new_3028207_3028296" /HighExp="LPh, HPh, BMM, dia0, Heat, G180, Cold, LBGexp, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1124" upshifts 2848714 /Source="Nicolas_upshifts" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" promotor_-10 2848716..2848735 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2848804..2850141 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11528000, 15849754, 16850406, 26473603" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11528000, 15849754, 16850406, 26473603; Product type t: transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid-Na+ symporter" /protein_id="NP_390838.1" /db_xref="EnsemblGenomes-Gn:BSU29600" /db_xref="EnsemblGenomes-Tr:CAB14938" /db_xref="GOA:O34545" /db_xref="InterPro:IPR004685" /db_xref="SubtiList:BG12573" /db_xref="UniProtKB/Swiss-Prot:O34545" /translation="MKHSLPVKDTIIIGFMLFALFFGAGNMIYPPELGQAAGHNVWKA IGGFLLTGVGLPLLGIIAIALTGKDAKGLADKAHPVFGTIFTVVLYLSIGPLFAIPRT GTVSYEIGAVPFLTGVPERLSLLIFTLIFFGVTYYLALNPSKVVDRVGKILTPIKFTI ILIIVLKAIFTPMGGLGAVTEAYKGTPVFKGFLEGYKTMDALASIVFGVVVVNAVKSK GVTQSKALAAACIKAGVIAALGLTFIYVSLAYLGATSTNAIGPVGEGAKILSASSHYL FGSLGNIVLGAAITVACLTTSIGLVTSCGQYFSKLIPALSYKIVVTIVTLFSLIIANF GLAQIIAFSVPILSAIYPLAIVIIVLSFIDKIFKERREVYIACLIGTGLFSILDGIKA AGFSLGSLDVFLNANLPLYSLGIGWVLPGIVGAVIGYVLTLFIGPSKQLNEIS*" gene 2848804..2850141 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" promotor_-10 complement(2849739..2849758) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2849753) /Source="Nicolas_upshifts" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" promotor_-35 complement(2849773..2849780) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2850117 /Source="Nicolas_upshifts" /id="D1518" /incds=0 /nref=69 /ntot=174 /MaxReadThrough="1.86149" /MaxDrop="6.26921" /score="14.5905051" /energy="-15.2" /TU="U2288" /idTUdmin="U2288" /TUdmin="-22" /isTUend="TRUE" CDS complement(2850236..2851924) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of FtsZ ring formation" /protein_id="NP_390839.1" /db_xref="EnsemblGenomes-Gn:BSU29610" /db_xref="EnsemblGenomes-Tr:CAB14939" /db_xref="GOA:O34894" /db_xref="InterPro:IPR010379" /db_xref="PDB:4UXV" /db_xref="SubtiList:BG13934" /db_xref="UniProtKB/Swiss-Prot:O34894" /translation="MEFVIGLLIVLLALFAAGYFFRKKIYAEIDRLESWKIEILNRSI VEEMSKIKHLKMTGQTEEFFEKWREEWDEIVTAHMPKVEELLYDAEENADKYRFKKAN QVLVHIDDLLTAAESSIEKILREISDLVTSEEKSREEIEQVRERYSKSRKNLLAYSHL YGELYDSLEKDLDEIWSGIKQFEEETEGGNYITARKVLLEQDRNLERLQSYIDDVPKL LADCKQTVPGQIAKLKDGYGEMKEKGYKLEHIQLDKELENLSNQLKRAEHVLMTELDI DEASAILQLIDENIQSVYQQLEGEVEAGQSVLSKMPELIIAYDKLKEEKEHTKAETEL VKESYRLTAGELGKQQAFEKRLDEIGKLLSSVKDKLDAEHVAYSLLVEEVASIEKQIE EVKKEHAEYRENLQALRKEELQARETLSNLKKTISETARLLKTSNIPGIPSHIQEMLE NAHHHIQETVNQLNELPLNMEEAGAHLKQAEDIVNRASRESEELVEQVILIEKIIQFG NRFRSQNHILSEQLKEAERRFYAFDYDDSYEIAAAAVEKAAPGAVEKIKADISA*" gene complement(2850236..2851924) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" downshifts complement(2850237) /Source="Nicolas_upshifts" /id="D1519" /incds=0 /nref=224 /ntot=257 /MaxReadThrough="3.34218" /MaxDrop="5.3305" /score="9.25784495" /energy="-8.6" /TU="U2290" /idTUdmin="U2290" /TUdmin="-66" /isTUend="FALSE" S_feature complement(2851925..2852030) /Source="Nicolas_S_feature" /locus_tag="new_3031418_3031523_c" /HighExp="C90, Lbtran, BMM, LBGtran, MG 150, S1, Lbexp, dia0, LBGexp, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1125" promotor_-35 2852007..2852015 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2852018..2852037) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2852026..2852045 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2852030) /Source="Nicolas_upshifts" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" upshifts 2852030 /Source="Nicolas_upshifts" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" S_feature 2852031..2852120 /Source="Nicolas_S_feature" /locus_tag="new_3031524_3031613" /HighExp="HiOs, C90, dia5, T-5.40H, S1, T-3.40H, GM-0.1, GM 15, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1126" S_feature complement(2852032..2852591) /Source="Nicolas_S_feature" /locus_tag="new_3031525_3032084_c" /HighExp="Etha, Salt, Cold, G135, Lbstat, G180, G150, H2O2, Heat, Paraq" /AntisenseName="hisJ" /AntisenseCor="0.37018688255337001" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1127" promotor_-35 complement(2852053..2852055) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2852121..2852927 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" /EC_number="3.1.3.15" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10322033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol phosphate phosphatase" /protein_id="NP_390840.1" /db_xref="EnsemblGenomes-Gn:BSU29620" /db_xref="EnsemblGenomes-Tr:CAB14940" /db_xref="GOA:O34411" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010140" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG13931" /db_xref="UniProtKB/Swiss-Prot:O34411" /translation="MQKRDGHIHTPFCPHGSNDTLRQYAEEALKKGFESITFTEHAPL PPSFTDPTPLKDSAMAQASLERYIHEISGLKKEYRGQLSIRTGLEVDYIAEFEDEITL FLDTYGPYLDDSILSVHFLRTDSSYLCLDYDEHTFKELISACGSIEAVYEQYYRSIYS SIVASLGVYKPKRVGHITLVQKFIKLFPYSMSEHIRGLVSLCLNAIEENGMELDFNTS GLRKTYAGGIYIEDWMLNEAKQKKIPLVFGSDAHQAGDVGYAYEAFLERC*" gene 2852121..2852927 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" promotor_-10 complement(2852595..2852614) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2852608) /Source="Nicolas_upshifts" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" promotor_-35 complement(2852626..2852633) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2852877..2852923) /Source="Nicolas_S_feature" /locus_tag="new_3032370_3032416_c" /HighExp="M9-stat, T5.0H, LoTm, T4.0H, S2, BC, T3.30H, S4, T3.0H, B60" /AntisenseName="hisJ" /AntisenseCor="-0.46006853678527698" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1128" downshifts complement(2852899) /Source="Nicolas_upshifts" /id="D1520" /incds=0 /nref=51 /ntot=97 /MaxReadThrough="1.55523" /MaxDrop="6.84653" /score="-4.34170655" /energy="-10.5" /TU="NA" /idTUdmin="U2296" /TUdmin=0 /isTUend="TRUE" CDS complement(2852924..2853547) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11988534, 22730127, 26360512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 22730127, 26360512; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of FtsZ defining the chromosome regioncaptured in the forespore" /protein_id="NP_390841.1" /db_xref="EnsemblGenomes-Gn:BSU29630" /db_xref="EnsemblGenomes-Tr:CAB14941" /db_xref="GOA:O34970" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG13927" /db_xref="UniProtKB/Swiss-Prot:O34970" /translation="MKVSTKDKIIESAVMLFNQKGFSGTSVREIAKSADVNVAHISYY FKGKGGLMEHLVSEFYEGYSKTLETAASNISTQSTQEQLLQLVFDILSYQHNHRQLTR FVYREVTIDSTLIREIMSTYLMKEKYIFQLIIEEGEKQREYLTLPLPHFILQLKSLLM MPYLQPQYISEVLYMQPHEPYFYKMYFEEIKIWIRSVFRTGDVALTN*" gene complement(2852924..2853547) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" S_feature 2852928..2853270 /Source="Nicolas_S_feature" /locus_tag="new_3032421_3032763" /HighExp="C90, HiOs, Sw, dia5, GM-0.1, S1, MG 5, UNK1, MG 60, MG t5" /AntisenseName="yttP" /AntisenseCor="-0.79169109805002003" /AntisenseRegPval="-58.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1129" promotor_-35 2853248..2853255 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2853270..2853289 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2853272..2853415 /Source="Nicolas_S_feature" /locus_tag="new_3032765_3032908" /HighExp="Diami, dia15, dia5, H2O2, C90, Paraq, Salt, Etha, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.81457903975257295" /AntisenseRegPval="-64.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1130" upshifts 2853272 /Source="Nicolas_upshifts" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" promotor_-35 2853387..2853391 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2853407..2853426 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2853417..2853547 /Source="Nicolas_S_feature" /locus_tag="new_3032910_3033040" /HighExp="Diami, dia15, dia5, H2O2, Paraq, C90, HPh, LBGexp, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.82273476313537297" /AntisenseRegPval="-66.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1131" upshifts 2853417 /Source="Nicolas_upshifts" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" S_feature 2853549..2853673 /Source="Nicolas_S_feature" /locus_tag="new_3033042_3033166" /HighExp="Diami, dia5, dia15, H2O2, C90, BC, HiOs, Paraq, Sw, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.598, 0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1132" upshifts 2853549 /Source="Nicolas_upshifts" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" promotor_-10 complement(2853563..2853581) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2853565..2853584 /Source="Nicolas_upshift_promotors" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2853581) /Source="Nicolas_upshifts" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" promotor_-35 complement(2853592..2853600) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2853674..2854165 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" /EC_number="1.8.4.14" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17535911, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="free methionine-(R)-sulfoxide reductase" /protein_id="NP_390842.2" /db_xref="EnsemblGenomes-Gn:BSU29640" /db_xref="EnsemblGenomes-Tr:CAB14942" /db_xref="InterPro:IPR000614" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG13923" /db_xref="UniProtKB/Swiss-Prot:O34553" /translation="MFHVEKQSGDKEKDYQLLLKQLEAMTEDETDQIANYANASALLY HSLPEVNWAGFYFAKEEDGQLVLGPFQGLPACVRIPFGRGVCGTAYANGKVERIEDVN AFPGHIACDAASQSEIVLPIRVDGKIVGVLDIDSPVKNRFDEIDEKYLTQFAETLEKA LAQ*" gene 2853674..2854165 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" downshifts 2854144 /Source="Nicolas_upshifts" /id="D1521" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="3.66093" /MaxDrop="6.50628" /score="34.0123402" /energy="-11.9" /TU="U2291,U2293,U2294" /idTUdmin="U2295" /TUdmin=0 /isTUend="TRUE" CDS complement(2854203..2855942) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" /EC_number="2.7.7.65" /function="16.12: Sense" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_390843.1" /db_xref="EnsemblGenomes-Gn:BSU29650" /db_xref="EnsemblGenomes-Tr:CAB14943" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG13918" /db_xref="UniProtKB/Swiss-Prot:O34325" /translation="MVEQTKDQLSAFHYHMLDFLLTKSEKVTFTDSFIWLTSAIQTYF STLCVSLTPSPSDFVTKLADGEARFSASKINASCYLIEDGSGRRFHLACRQDEEIPEG LPDVVASFLNQSMKQERLYNKTIYQKKIYKMTELFHSLLDQTDVLKQLLESLTSTFSL FEFSLFISHDQDQCLGIPAKELYMEGEKSDSFALKVYLSGDILRKNESVAYIPIKGQQ GTYGVLKAEGTGDSFLTDACLDEMSLLANAAGKAFENAQLYEQSKASIANLELINETS RRLNQRLTLTDTMNDLAVRMAESFQAEEVGFFHIDHFENLTLLPGSTAFFKEAKPSDF YNELKEKLYEGEKGVFIGNGQSVFGKAGYGSLMAAPMIQNDRLLGFAVLLKQELYAFT FEMYKLFQALIHHATLAVTNSMLRDRLEHLVKTDQLTELYSRAYLDEKIQYSMKIHQK GVFILVDIDNFKNVNDTYGHQTGDEILIQVASVIKSNIRKHDVGARWGGEELAIYLPN VPVAVGKRITERLVYAVRKNTKPEVTISCGISCWTTETKKSLKELVHEADEALYSAKR SGKNRLMIHDSIK*" gene complement(2854203..2855942) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" downshifts complement(2854221) /Source="Nicolas_upshifts" /id="D1522" /incds=0 /nref=23 /ntot=178 /MaxReadThrough="3.68958" /MaxDrop="4.52201" /score="-0.637788006" /energy="-11.9" /TU="U2298" /idTUdmin="U2298" /TUdmin="-45" /isTUend="FALSE" promotor_-35 2855416..2855423 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-35" promotor_-10 2855437..2855455 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-10" upshifts 2855440 /Source="Nicolas_upshifts" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" S_feature 2855442..2856037 /Source="Nicolas_S_feature" /locus_tag="new_3034935_3035530" /HighExp="Cold, LBGstat, C30, Lbstat, GM 25, GM 10, GM 120, GM-0.1, GM 5, GM-0.2" /AntisenseName="ytrP" /AntisenseCor="-0.113221814489707" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1133" misc_feature complement(2855972..2855991) /Source="Nicolas_upshift_promotors" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2855980) /Source="Nicolas_upshifts" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" S_feature complement(2855982..2856815) /Source="Nicolas_S_feature" /locus_tag="new_3035475_3036308_c" /HighExp="Etha, S7, Gly, S8, M9-stat, Sw, G135, S6, BC, C30" /AntisenseName="rpsD" /AntisenseCor="-0.48019282175486899" /AntisenseRegPval="-16.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1134" promotor_-35 2856018..2856025 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2856039..2856236 /Source="Nicolas_S_feature" /locus_tag="new_3035532_3035729" /HighExp="UNK1, Cold, HPh, C30, aero, LPhT, MG 25, Oxctl, Heat, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.139124" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1135" promotor_-10 2856039..2856058 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2856039 /Source="Nicolas_upshifts" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" misc_RNA 2856096..2856228 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" /product="ribosomal protein S4 leader mRNA sequence" /experiment="publication(s) with functional evidences, PMID:23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23611891" gene 2856096..2856228 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" CDS 2856237..2856839 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1400226, 1699930, 1906866, 12682299, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400226, 1699930, 1906866, 12682299, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S4 (BS4)" /protein_id="NP_390844.1" /db_xref="EnsemblGenomes-Gn:BSU29660" /db_xref="EnsemblGenomes-Tr:CAB14944" /db_xref="GOA:P21466" /db_xref="InterPro:IPR001912" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR005709" /db_xref="InterPro:IPR018079" /db_xref="InterPro:IPR022801" /db_xref="InterPro:IPR036986" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10372" /db_xref="UniProtKB/Swiss-Prot:P21466" /translation="MARYTGPSWKLSRRLGISLSGTGKELEKRPYAPGPHGPGQRKKL SEYGLQLQEKQKLRHMYGVNERQFRTLFDKAGKLAGKHGENFMILLDSRLDNVVYKLG LARTRRQARQLVNHGHILVDGSRVDIPSYLVKPGQTIGVREKSRNLSIIKESVEVNNF VPEYLTFDAEKLEGTFTRLPERSELAPEINEALIVEFYSR*" gene 2856237..2856839 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" downshifts 2856762 /Source="Nicolas_upshifts" /id="D1523" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="8.1141" /MaxDrop="2.9392" /score="31.6842" /energy="-13.6" /TU="U2297,U2299" /idTUdmin="U2297" /TUdmin="-44" /isTUend="FALSE" S_feature complement(2856817..2857036) /Source="Nicolas_S_feature" /locus_tag="new_3036310_3036529_c" /HighExp="S5, Etha, S8, S6, S7, S4, BT, S3, M9-stat, B36" /AntisenseName="rpsD" /AntisenseCor="-0.59018291599064199" /AntisenseRegPval="-25.9" /CDS_PredictionProba="0.99997899999999995" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1136" downshifts 2856825 /Source="Nicolas_upshifts" /id="D1524" /incds=0 /nref=135 /ntot=252 /MaxReadThrough="5.6866" /MaxDrop="6.10502" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=19 /isTUend="TRUE" downshifts complement(2856860) /Source="Nicolas_upshifts" /id="D1525" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="4.84346" /MaxDrop="3.28594" /score="-4.07107651" /energy="-10.8" /TU="U2300" /idTUdmin="U2301" /TUdmin=264 /isTUend="FALSE" downshifts 2856872 /Source="Nicolas_upshifts" /id="D1526" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="5.7799" /MaxDrop="4.26349" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=66 /isTUend="FALSE" S_feature 2856917..2857090 /Source="Nicolas_S_feature" /locus_tag="new_3036410_3036583" /HighExp="LBGtran, LoTm, C30, Cold, LBGexp, B60, dia15, B36, H2O2, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig=1 /label="S1137" promotor_-10 complement(2857032..2857050) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2857044) /Source="Nicolas_upshifts" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" downshifts 2857048 /Source="Nicolas_upshifts" /id="D1527" /incds=0 /nref=7 /ntot=151 /MaxReadThrough="1.39547" /MaxDrop="6.12149" /score="26.4940291" /energy="-16.4" /TU="NA" /idTUdmin="U2299" /TUdmin=0 /isTUend="TRUE" promotor_-35 complement(2857065..2857071) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2857110..2858378) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" /EC_number="6.1.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12547201, 15879350, 1735721, 9098057" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12547201, 15879350, 1735721, 9098057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_390845.1" /db_xref="EnsemblGenomes-Gn:BSU29670" /db_xref="EnsemblGenomes-Tr:CAB14945" /db_xref="GOA:P22326" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024107" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10371" /db_xref="UniProtKB/Swiss-Prot:P22326" /translation="MTNLLEDLSFRGLIQQMTDEEGLNKQLNEEKIRLYSGFDPTADS LHIGHLLPILTLRRFQLAGHHPIALVGGATGLIGDPSGKKAERTLNTADIVSEWSQKI KNQLSRFLDFEAAENPAVIANNFDWIGKMNVIDFLRDVGKNFGINYMLAKDTVSSRIE SGISYTEFSYMILQSYDFLNLYRDKNCKLQIGGSDQWGNITAGLELIRKSEEEGAKAF GLTIPLVTKADGTKFGKTEGGAIWLDKEKTSPYEFYQFWINTDDRDVVKYLKYFTFLS KEEIEAYAEKTETAPEKREAQKRLAEEVTSLVHGREALEQAINISQALFSGNIKELSA QDVKVGFKDVPSMEVDSTQELSLVDVLVQSKLSPSKRQAREDIQNGAVYINGERQTEI NYTLSGEDRIENQFTVLRRGKKKYFLVTYK*" gene complement(2857110..2858378) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" downshifts complement(2857136) /Source="Nicolas_upshifts" /id="D1528" /incds=0 /nref=110 /ntot=357 /MaxReadThrough="2.2673" /MaxDrop="6.847" /score="22.5238672" /energy="-16.4" /TU="NA" /idTUdmin="U2301" /TUdmin="-12" /isTUend="TRUE" misc_RNA complement(2858402..2858675) /gene="tboY" /locus_tag="BSU_misc_RNA_83" /product="T-Box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 10943892, 1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 10943892, 1317842, 9098041, 12165569, 12547201; Product type n : RNA" /function="16.3: Control" gene complement(2858402..2858675) /gene="tboY" /locus_tag="BSU_misc_RNA_83" S_feature complement(2858423..2858566) /Source="Nicolas_S_feature" /locus_tag="new_3037916_3038059_c" /HighExp="B60, Sw, B36, BC, M9-stat, T1.30H, S4, T4.0H, T2.30H, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40126600000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1138" downshifts complement(2858466) /Source="Nicolas_upshifts" /id="D1529" /incds=0 /nref=58 /ntot=127 /MaxReadThrough="6.75235" /MaxDrop="6.49727" /score="45.7279775" /energy="-17.7" /TU="U2301,U2303" /idTUdmin="U2301" /TUdmin="-1342" /isTUend="FALSE" promotor_-10 complement(2858673..2858692) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2858685) /Source="Nicolas_upshifts" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" promotor_-35 complement(2858705..2858712) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2858720..2860438) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" /EC_number="6.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7934817, 10986270, 11255012, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10986270, 11255012, 16855235, 18487328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA synthetase" /protein_id="NP_390846.1" /db_xref="EnsemblGenomes-Gn:BSU29680" /db_xref="EnsemblGenomes-Tr:CAB14946" /db_xref="GOA:P39062" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG10370" /db_xref="UniProtKB/Swiss-Prot:P39062" /translation="MNLKALPAIEGDHNLKNYEETYRHFDWAEAEKHFSWHETGKLNA AYEAIDRHAESFRKNKVALYYKDAKRDEKYTFKEMKEESNRAGNVLRRYGNVEKGDRV FIFMPRSPELYFIMLGAIKIGAIAGPLFEAFMEGAVKDRLENSEAKVVVTTPELLERI PVDKLPHLQHVFVVGGEAESGTNIINYDEAAKQESTRLDIEWMDKKDGFLLHYTSGST GTPKGVLHVHEAMIQQYQTGKWVLDLKEEDIYWCTADPGWVTGTVYGIFAPWLNGATN VIVGGRFSPESWYGTIEQLGVNVWYSAPTAFRMLMGAGDEMAAKYDLTSLRHVLSVGE PLNPEVIRWGHKVFNKRIHDTWWMTETGSQLICNYPCMDIKPGSMGKPIPGVEAAIVD NQGNELPPYRMGNLAIKKGWPSMMHTIWNNPEKYESYFMPGGWYVSGDSAYMDEEGYF WFQGRVDDVIMTSGERVGPFEVESKLVEHPAIAEAGVIGKPDPVRGEIIKAFIALREG FEPSDKLKEEIRLFVKQGLAAHAAPREIEFKDKLPKTRSGKIMRRVLKAWELNLPAGD LSTMED*" gene complement(2858720..2860438) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" promotor_-35 2860452..2860459 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2860466..2860485) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2860474..2860493 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2860480 /Source="Nicolas_upshifts" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(2860489) /Source="Nicolas_upshifts" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" promotor_-35 complement(2860499..2860505) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2860522..2860529 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2860543..2860562 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2860546 /Source="Nicolas_upshifts" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" CDS 2860599..2861231 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein acetyltransferase (acetylates AcsA)" /protein_id="NP_390847.1" /db_xref="EnsemblGenomes-Gn:BSU29690" /db_xref="EnsemblGenomes-Tr:CAB14947" /db_xref="GOA:P39065" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR024699" /db_xref="SubtiList:BG10369" /db_xref="UniProtKB/Swiss-Prot:P39065" /translation="MEHHKTYHSANIKTATGSLLIEGPVSPEDLAGYEFHKDLTAFRP PREQHEALVDIAGLPEGRIIIARDGRTIVGYVTYLYPDPLERWSEGNMEDLIELGAIE VAPDYRGCAVGKTLLTVSMMDEQMENYIVMTTEYYWHWDLKGMKKDVWEYRKIMEKMM NAGGLVWFATDEPEISSHPANCLMARIGKNVSQESIEQFDRLRFYHRYMY*" gene 2860599..2861231 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" promotor_-35 2860804..2860812 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2860826..2860845 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2860832 /Source="Nicolas_upshifts" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" CDS 2861258..2861902 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type f : factor" /codon_start=1 /transl_table=11 /product="component of the acetyl-coenzyme A synthetase regulation pathway" /protein_id="NP_390848.1" /db_xref="EnsemblGenomes-Gn:BSU29700" /db_xref="EnsemblGenomes-Tr:CAB14948" /db_xref="GOA:P39066" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG10368" /db_xref="UniProtKB/Swiss-Prot:P39066" /translation="MIVEQIMKRDVITLTKTDTLETAICKLKEFHIRHLPVVDEERHV IGMITDRDMKQASPSIFEENKRSLFLTRSVDSIMKKDVVCAHPLDFVEEISAVFYEHG IGCLPVVHHQKLIGILTKTDLLRTFVKLTGADQPGSQIEIKVNDITKSLAEISSLCQD LQVKILSVLVYPHDDPGVKVLVFRVKTMNPLPFLQALQRNGHHVVWPSEQRDLL*" gene 2861258..2861902 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" CDS 2861899..2863062 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein deacetylase (regulates AcsA activity)" /protein_id="NP_390849.1" /db_xref="EnsemblGenomes-Gn:BSU29710" /db_xref="EnsemblGenomes-Tr:CAB14949" /db_xref="GOA:P39067" /db_xref="InterPro:IPR000286" /db_xref="InterPro:IPR003085" /db_xref="InterPro:IPR023696" /db_xref="InterPro:IPR023801" /db_xref="InterPro:IPR037138" /db_xref="SubtiList:BG10367" /db_xref="UniProtKB/Swiss-Prot:P39067" /translation="MRDSVFIYSPSYQTYMFHQEHPFNQQRVLLTYDLLKTINAFDDG DIVTPRLASEEELSLVHTDDYIQAVKLAGAGKLPAEEGESYGLGTEDTPVFAGMHEAA SLLVGGTLTAADWVMSGQALHAANLGGGLHHGFRGRASGFCIYNDSAVAIQYIQKKYS ARVLYIDTDAHHGDGVQFTFYDNPDVCTLSIHETGRYLFPGTGQIQEKGSGKGYGYSF NIPLDAFTEDDSFLEAYRTAASEVAAYFEPDVIISQNGADAHYYDPLTHLSATINIYE EIPRLAHTLAHQYCGGKWIAVGGGGYDIWRVVPRAWARIWLEMKGIDPGHEIPPEWIV KWQKQCPVALPSSWSDPADLYPPIPRKPEITEKNAQTVSKALYAIRSEQQRTK*" gene 2861899..2863062 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" downshifts 2863053 /Source="Nicolas_upshifts" /id="D1530" /incds=0 /nref=98 /ntot=231 /MaxReadThrough="0.530530000000001" /MaxDrop="6.5095" /score="10.9528437" /energy="-9.1" /TU="NA" /idTUdmin="U2304" /TUdmin="-1" /isTUend="TRUE" CDS complement(2863073..2863801) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator peptidoglycan binding subunit of flagellar rotation" /protein_id="NP_390850.1" /db_xref="EnsemblGenomes-Gn:BSU29720" /db_xref="EnsemblGenomes-Tr:CAB14950" /db_xref="GOA:P39064" /db_xref="InterPro:IPR006665" /db_xref="InterPro:IPR025713" /db_xref="InterPro:IPR036737" /db_xref="SubtiList:BG10366" /db_xref="UniProtKB/Swiss-Prot:P39064" /translation="MKLRRERFERRNGSGKNSQSSSSWMVTFTDLITLILVFFILLFS MSQIDLQKFKAAVDSIQKEGNGLQPDQTSIEKKNTSPSDTKKQEDQQDQLLKKVNTYI KDNHLKAQMTAKRDERGVVLVLQEAVLFDTGEAKVLKNAETLLHQIAVLLQTIPNDIQ VEGHTDSRNISTYRYPSNWELSAARASGVIQYFTSKEKLPSKRFIAVGYADTKPVKDN KTNEHMKENRRVEIVIKKSKTTSS*" gene complement(2863073..2863801) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" downshifts complement(2863109) /Source="Nicolas_upshifts" /id="D1531" /incds=0 /nref=37 /ntot=149 /MaxReadThrough="1.3853" /MaxDrop="3.98206" /score="4.77211813" /energy="-6.9" /TU="NA" /idTUdmin="U2307" /TUdmin="-1" /isTUend="TRUE" CDS complement(2863791..2864609) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator subunit offlagellar rotation" /protein_id="NP_390851.1" /db_xref="EnsemblGenomes-Gn:BSU29730" /db_xref="EnsemblGenomes-Tr:CAB14951" /db_xref="GOA:P39063" /db_xref="InterPro:IPR000540" /db_xref="InterPro:IPR002898" /db_xref="SubtiList:BG10365" /db_xref="UniProtKB/Swiss-Prot:P39063" /translation="MKRFDYLTPVGFVLGTIIIVIGIISGSGVSGFRSFLDLTSFFIV TGGLCAAVFISFPPSELKKAPSVLKQAFIRQEDNVKDLVKTFVSLSDHARKHGLLSLD DQAREIKDPFLKKGLLLAIDGWDEETIRLVMDSEIAAMEERHRKGRRVFEKAGEFAPA WGMIGTLVGLVLMLKNLNDPHMLGPNMAIALLTTLYGSLLANMVFNPIAAKLEEKTES EIFIKQVMVEGIIGVQSGKNPRNLESQLVVFSSREEWQKQPKQVKTKKGSVHEA*" gene complement(2863791..2864609) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" CDS complement(2864672..2865676) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catabolite repression (Lacl family)" /protein_id="NP_390852.1" /db_xref="EnsemblGenomes-Gn:BSU29740" /db_xref="EnsemblGenomes-Tr:CAB14952" /db_xref="GOA:P25144" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR006377" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="PDB:1ZVV" /db_xref="PDB:2FEP" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10376" /db_xref="UniProtKB/Swiss-Prot:P25144" /translation="MSNITIYDVAREANVSMATVSRVVNGNPNVKPTTRKKVLEAIER LGYRPNAVARGLASKKTTTVGVIIPDISSIFYSELARGIEDIATMYKYNIILSNSDQN MEKELHLLNTMLGKQVDGIVFMGGNITDEHVAEFKRSPVPIVLAASVEEQEETPSVAI DYEQAIYDAVKLLVDKGHTDIAFVSGPMAEPINRSKKLQGYKRALEEANLPFNEQFVA EGDYTYDSGLEALQHLMSLDKKPTAILSATDEMALGIIHAAQDQGLSIPEDLDIIGFD NTRLSLMVRPQLSTVVQPTYDIGAVAMRLLTKLMNKEPVEEHIVELPHRIELRKSTKS *" gene complement(2864672..2865676) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" downshifts complement(2864689) /Source="Nicolas_upshifts" /id="D1532" /incds=0 /nref=62 /ntot=239 /MaxReadThrough="4.60553" /MaxDrop="4.6531" /score="5.3377823" /energy="-13.2" /TU="U2307,U2308,U2309" /idTUdmin="U2306" /TUdmin=3 /isTUend="TRUE" misc_feature complement(2865711..2865730) /Source="Nicolas_upshift_promotors" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2865726) /Source="Nicolas_upshifts" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" S_feature complement(2865728..2865836) /Source="Nicolas_S_feature" /locus_tag="new_3045221_3045329_c" /HighExp="Oxctl, H2O2, Paraq, MG-0.1, MG-0.2, G150, GM 15, Diami, LBGexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigB" /TUshortPSig="0.988, 1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1139" promotor_-10 complement(2865836..2865855) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2865836) /Source="Nicolas_upshifts" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" S_feature complement(2865838..2865903) /Source="Nicolas_S_feature" /locus_tag="new_3045331_3045396_c" /HighExp="BMM, GM 120, Diami, GM 90, M/G, GM 25, M9-exp, HiTm, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1140" promotor_-35 complement(2865869..2865875) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2865949) /Source="Nicolas_upshifts" /id="D1533" /incds=0 /nref=66 /ntot=188 /MaxReadThrough="6.10221" /MaxDrop="6.29667" /score="46.0872381" /energy="-11.3" /TU="U2308,U2309,U2310" /idTUdmin="U2311" /TUdmin="-2" /isTUend="TRUE" CDS complement(2865952..2867028) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" /EC_number="2.5.1.54" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4200844, 7496534, 11444986, 16339761, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4200844, 7496534, 11444986, 16339761, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional chorismate mutase type II-isozyme 3(regulatory domain); 3-deoxy-D-arabino-heptulosonate7-phosphate synthase" /protein_id="NP_390853.1" /db_xref="EnsemblGenomes-Gn:BSU29750" /db_xref="EnsemblGenomes-Tr:CAB14953" /db_xref="GOA:P39912" /db_xref="InterPro:IPR002701" /db_xref="InterPro:IPR006218" /db_xref="InterPro:IPR006268" /db_xref="InterPro:IPR010954" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036979" /db_xref="PDB:5GMU" /db_xref="PDB:5GO2" /db_xref="SubtiList:BG10375" /db_xref="UniProtKB/Swiss-Prot:P39912" /translation="MSNTELELLRQKADELNLQILKLINERGNVVKEIGKAKEAQGVN RFDPVRERTMLNNIIENNDGPFENSTIQHIFKEIFKAGLELQEEDHSKALLVSRKKKP EDTIVDIKGEKIGDGQQRFIVGPCAVESYEQVAEVAAAAKKQGIKILRGGAFKPRTSP YDFQGLGVEGLQILKRVADEFDLAVISEIVTPAHIEEALDYIDVIQIGARNMQNFELL KAAGAVKKPVLLKRGLAATISEFINAAEYIMSQGNDQIILCERGIRTYETATRNTLDI SAVPILKQETHLPVFVDVTHSTGRRDLLLPTAKAALAIGADGVMAEVHPDPSVALSDS AQQMAIPEFEKWLNELKPMVKVNA*" gene complement(2865952..2867028) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" promotor_-10 complement(2867069..2867088) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-10" upshifts complement(2867089) /Source="Nicolas_upshifts" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" S_feature complement(2867091..2867191) /Source="Nicolas_S_feature" /locus_tag="new_3046584_3046684_c" /HighExp="Lbtran, BMM, dia5, GM 25, GM 90, M9-exp, MG 150, Diami, MG-0.2, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigH" /TUshortPSig="0.974, 1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1141" promotor_-35 complement(2867103..2867110) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-35" downshifts 2867125 /Source="Nicolas_upshifts" /id="D1534" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.07872" /MaxDrop="3.23284" /score="1.10447256" /energy="-7.6" /TU="NA" /idTUdmin="U2304" /TUdmin=4071 /isTUend="FALSE" promotor_-10 complement(2867179..2867198) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2867191) /Source="Nicolas_upshifts" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" promotor_-35 complement(2867212..2867218) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2867264..2867590) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22938038, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22938038, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin involved in debacillithiolation" /protein_id="NP_390854.1" /db_xref="EnsemblGenomes-Gn:BSU29760" /db_xref="EnsemblGenomes-Tr:CAB14954" /db_xref="InterPro:IPR022551" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10373" /db_xref="UniProtKB/Swiss-Prot:P39914" /translation="MAKQLIQSEEEFKRIAEQEGVFVFLKHSTTCPISQAAFHEFDAF ANQHEDVPAYYLQVQEARPLSNFIAETYGVKHESPQIFIIQNGEVKWHTSHSQITEAA IEQHLS*" gene complement(2867264..2867590) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" downshifts complement(2867273) /Source="Nicolas_upshifts" /id="D1535" /incds=0 /nref=144 /ntot=286 /MaxReadThrough="7.09736" /MaxDrop="5.96753" /score="13.8032115" /energy="-7.6" /TU="U2310,U2311" /idTUdmin="U2313" /TUdmin="-6" /isTUend="TRUE" CDS complement(2867614..2868069) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8733232, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390855.2" /db_xref="EnsemblGenomes-Gn:BSU29770" /db_xref="EnsemblGenomes-Tr:CAB14955" /db_xref="InterPro:IPR024623" /db_xref="SubtiList:BG10975" /db_xref="UniProtKB/Swiss-Prot:P40780" /translation="MSKDGINSKDFLIGTLIGGIIGATTALFLAPKSGKELRDDLGSQ AVALRDKTDKMTADAKEKGTQYVSIAKDKTSNITQLVADQSGQIMNKVKDLRDRSKSD KTDSSTAMQDMREEAMQAADETKDQVLQTKEDVKDELKDAQKQAEQLNR*" gene complement(2867614..2868069) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" CDS complement(2868100..2868522) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22720735, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein" /protein_id="NP_390856.2" /db_xref="EnsemblGenomes-Gn:BSU29780" /db_xref="EnsemblGenomes-Tr:CAB14956" /db_xref="GOA:P40779" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG10974" /db_xref="UniProtKB/Swiss-Prot:P40779" /translation="MIIILYLSVALIAVAFLVLVIYLSKTLKSLQLTLKNVASTLEGL EGQMKGITTETAELLHKTNRLAEDIQEKSEKLNTVVHAVQGVGASVQQFNTSMKQAAG SVSASVRENQDKINQVVTWSQAAMEIWEKWKQKKKSAL*" gene complement(2868100..2868522) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" promotor_-10 complement(2868543..2868561) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2868556) /Source="Nicolas_upshifts" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" promotor_-35 complement(2868575..2868581) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2868595..2868613) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-10" upshifts complement(2868604) /Source="Nicolas_upshifts" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" promotor_-35 complement(2868624..2868632) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-35" CDS complement(2868684..2869982) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" /EC_number="6.3.2.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10565540, 12682299, 12781748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetyl muramate-alanine ligase" /protein_id="NP_390857.1" /db_xref="EnsemblGenomes-Gn:BSU29790" /db_xref="EnsemblGenomes-Tr:CAB14957" /db_xref="GOA:P40778" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005758" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10973" /db_xref="UniProtKB/Swiss-Prot:P40778" /translation="MTVYHFVGIKGTGMSPLAQILHDNGYTVQGSDIEKFIFTQTALE KRNITILPFSAENIKPGMTVIAGNAFPDTHPEIEKAMSEGIPVIRYHKFLGDYMKKFT SVAVTGAHGKTSTTGLLAHVIQNAKPTSFLIGDGTGQGNENSEYFVFEACEYRRHFLS YQPDYAIMTNIDFDHPDYFSSIDDVFDAFQEMALQVNKGIIACGDDEHLPKIHANVPV VYYGTGEENDFQARNIVKSTEGTTFDVFVRNTFYDTFYIPAYGHHNVLNSLAVIALCH YEEIDSSIIKHALKSFGGVKRRFNEKQLGDQVLIDDYAHHPTEIKVTIEAARQKYPDR EIVAVFQPHTFTRTQQFLDEFAESLSGADCVYLCDIFGSARENAGKLTIGDLQGKIHN AKLIEEDDTSVLKAHDKAVLIFMGAGDIQKYMRAYENVMA*" gene complement(2868684..2869982) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" downshifts complement(2868693) /Source="Nicolas_upshifts" /id="D1536" /incds=0 /nref=29 /ntot=180 /MaxReadThrough="5.23049" /MaxDrop="5.42617" /score="15.3729968" /energy="-7.5" /TU="U2313,U2314" /idTUdmin="U2312" /TUdmin="-5" /isTUend="TRUE" promotor_-10 complement(2870007..2870026) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2870008) /Source="Nicolas_upshifts" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" S_feature complement(2870010..2870206) /Source="Nicolas_S_feature" /locus_tag="new_3049503_3049699_c" /HighExp="Cold, G150, G135, dia15, G180, H2O2, C30, Oxctl, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.938" /label="S1142" promotor_-35 complement(2870039..2870048) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2870189..2870208) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2870206) /Source="Nicolas_upshifts" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" promotor_-35 complement(2870220..2870226) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2870232..2873090) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" /function="8.1: DNA replication, recombination, and repair" /experiment="publication(s) with functional evidences, PMID:3129532, 11134515, 11208805, 19788545, 28110333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3129532, 11134515, 11208805, 19788545, 28110333; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="DNA translocase" /protein_id="NP_390859.2" /db_xref="EnsemblGenomes-Gn:BSU29805" /db_xref="EnsemblGenomes-Tr:CAB14959" /db_xref="GOA:C0SP86" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13906" /db_xref="UniProtKB/Swiss-Prot:C0SP86" /translation="MSWLHKFFDLFLGESEEDAERETKPAQIPQQQEVHHPEGQLKRL EDPKIYYEYPKGKFRFPVVPDGYKNHDLRRRRTPSDEPKSAPRPSAAPYRERPRNEEE QHTYQAAEPAKKPFKPTNIPSPVYGFNQKPSVKKDVPKKPSETLNEPDKSVKEKVTLL SEEIERERGYPASDTQAHSKIESPFFPDTQFEKQPSGVLNRKDTEHDEALAKRPAEPS GNKVPFESGVQQPEKEEPFFPAEQAEEQTPPEMLTDTAAEGLSDSEVGREEPATAEEE QREQQPEKFEEPVFSAELDEEQTAPESQTEAVSEDEKAKEPSDSPVYNHHENAAEGAE SPFVQEEQMDIRQEEPLFTDHEYSSEALAQAETVAKESEEPSESIINNHYDTLGEAQE TKIDVQPDSHTELEKTEHMEQGSKSSTATLENRQEIRADKPREASEEPKKRPGVQEKR TEQSASSQKGPSVPFNVMMLKRDTHKQQKAEERRGSYVFPNVALLDVPPAQVQDDTAW IEEQRQLLDLTLKNFNVRANVVHVTQGPSVTRFEVHPEPGVKVNKITNLSDDIKLSLS AKDIRIEAPIPGKNTIGIEVPNRTSKVVDLRQMIRSSAFRTSKSPLTAALGLDISGNP VVIDLKKMPHGLIAGATGSGKSVCINTILVSLLYKADPSEVKVLLIDPKMVELAPYNK IPHLVSPVITDAKAATAALKWVVEEMERRYELFAHSGVRDIDRFNQLTAEHQMGEKLP YLVVIIDELADLMMVAPNDVEESIARIAQKARACGIHLLVATQRPSVDVITGLIKANI PTRIAFSVSSQVDSRTIIDIAGAEKLLGKGDMLFLENGSGKPVRLQGNFVSDREIDRV VSHVRSQMPPTYLFEQEELVRQGSALKEEDELFYEACEFVVEQNSASTSSLQRRFRIG YNRAARLIDMMEAEGMISEAKGSKPREVLITASDLINE*" gene complement(2870232..2873090) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" promotor_-10 complement(2873124..2873143) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-10" upshifts complement(2873134) /Source="Nicolas_upshifts" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" promotor_-35 complement(2873159..2873163) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-35" downshifts complement(2873233) /Source="Nicolas_upshifts" /id="D1537" /incds=0 /nref=186 /ntot=249 /MaxReadThrough="4.47299" /MaxDrop="6.35097" /score="9.62039509" /energy="-14.5" /TU="U2315" /idTUdmin="U2315" /TUdmin="-1553" /isTUend="FALSE" CDS complement(2873250..2873855) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21949854, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA binding enzyme" /protein_id="NP_390860.1" /db_xref="EnsemblGenomes-Gn:BSU29820" /db_xref="EnsemblGenomes-Tr:CAB14960" /db_xref="GOA:O34943" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027855" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR037154" /db_xref="SubtiList:BG13905" /db_xref="UniProtKB/Swiss-Prot:O34943" /translation="MNAFYNKEGVGDTLLISLQDVTREQLGYEKHGDVVKIFNNETKE TTGFNIFNASSYLTIDENGPVALSETFVQDVNEILNRNGVEETLVVDLSPKFVVGYVE SKEKHPNADKLSVCKVNVGEETLQIVCGAPNVDQGQKVVVAKVGAVMPSGLVIKDAEL RGVPSSGMICSAKELDLPDAPAEKGILVLEGDYEAGDAFQF*" gene complement(2873250..2873855) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" CDS complement(2873871..2874680) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12719520, 21949854" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (iron homeostasis)" /protein_id="NP_390861.1" /db_xref="EnsemblGenomes-Gn:BSU29830" /db_xref="EnsemblGenomes-Tr:CAB14961" /db_xref="InterPro:IPR010838" /db_xref="SubtiList:BG13904" /db_xref="UniProtKB/Swiss-Prot:O34496" /translation="MKMTSRKLSDILKQRLQHENRSFLFDREKDTLRVEDQTTKKGIT LDLPPIIAKWELKKDEAIDEIVYYVSEAMTAMEGKAQEMTGKETRIYPVIRSTSFPDK SSEDIPLIYDDHTAETRIYYALDLGKTYRLIDQRMLEKENWTKERIRETAAFNLRSLP TVVKEDTVAGNYFYFFRANDGYDASRILNEAILNEYKQHAEGELAISVPHQDVLILAD IRNESGYDILGQMSMSFFAGGTVPITALSFLYNEGKLEPVFILAKSRPKKD*" gene complement(2873871..2874680) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" CDS complement(2874695..2875018) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12719520, 15937154, 21949854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_390862.1" /db_xref="EnsemblGenomes-Gn:BSU29840" /db_xref="EnsemblGenomes-Tr:CAB14962" /db_xref="GOA:O34357" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13903" /db_xref="UniProtKB/Swiss-Prot:O34357" /translation="MKKIESTQELEKAVKDDWSVFMFSADWCPDCRFVEPFLPELEAN FPEFTYYYVDRDKFIDTCAEWEIYGIPSFVVFNEGKEVNRFVSKDRKTKEEIEQFLTD SLAKA*" gene complement(2874695..2875018) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" S_feature complement(2875019..2875157) /Source="Nicolas_S_feature" /locus_tag="new_3054512_3054650_c" /HighExp="G180, G150, Paraq, Oxctl, H2O2, Diami, C90, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.32150299999999998" /TUshortSig="SigA" /TUshortPSig="0.938" /TUlongSig="NA" /TUlongPSig="NA" /label="S1143" CDS complement(2875057..2875173) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513998.1" /translation="MQIKYDNDNGKANLTYSFVAYKWFCLKQFGMIQMDEYR*" gene complement(2875057..2875173) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" promotor_-10 complement(2875144..2875163) /Source="Nicolas_upshift_promotors" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="promotor_-10" upshifts complement(2875157) /Source="Nicolas_upshifts" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" promotor_-35 2875165..2875172 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2875179) /Source="Nicolas_upshift_promotors" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="promotor_-35" promotor_-10 2875187..2875206 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2875192 /Source="Nicolas_upshifts" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" CDS 2875253..2875699 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with sugar binding fold" /protein_id="NP_390863.1" /db_xref="EnsemblGenomes-Gn:BSU29850" /db_xref="EnsemblGenomes-Tr:CAB14963" /db_xref="InterPro:IPR019884" /db_xref="SubtiList:BG13899" /db_xref="UniProtKB/Swiss-Prot:O34305" /translation="MEFIVYLAGEIHSNWREEIKEKTKSLKLPITFVGPMENHDRSDN IGEEIMGVQPNAVLKDDKASDINNFRTAVLMNKADFVIALFGEKYKQWNTAMDASYAI AKGKPLIIIRPESLHHPLKELSNKANITVETVNQAIKALSYLFETE*" gene 2875253..2875699 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" S_feature 2875700..2876428 /Source="Nicolas_S_feature" /locus_tag="new_3055193_3055921" /HighExp="H2O2, dia15, C30, C90, Diami, S1, M0t45, Salt, Paraq, Lbexp" /AntisenseName="ytoP" /AntisenseCor="0.35418735783791" /AntisenseRegPval="-8.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.981" /TUlongSig="NA" /TUlongPSig="NA" /label="S1144" CDS complement(2875754..2876827) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8535515; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative modified amino acid aminopeptidase" /protein_id="NP_390864.1" /db_xref="EnsemblGenomes-Gn:BSU29860" /db_xref="EnsemblGenomes-Tr:CAB14964" /db_xref="GOA:O34924" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13898" /db_xref="UniProtKB/Swiss-Prot:O34924" /translation="MNQETKALFQTLTQLPGAPGNEHQVRAFMKQELAKYADDIVQDR LGSVFGVRRGAEDAPRIMVAGHMDEVGFMVTSITDNGLLRFQTLGGWWSQVLLAQRVE IQTDNGPVPGVISSIPPHLLTDAQRNRPMDIKNMMIDIGADDKEDAIKIGIRPGQQIV PVCPFTTMANEKKILSKAWDNRYGCGLSIELLKELHGKELPNTLYAGATVQEEVGLRG AQTASHMIKPDLFFALDASPANDMSGDKNEFGQLGKGFLLRILDRTTVMHRGMREFVL DMAETHDIPYQYFVSGGGTDAGKVHISNSGVPSAVIGICSRYIHTNATIIHIDDYAAA KEMLIKLVTACDKQTVDAIKENM*" gene complement(2875754..2876827) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" downshifts complement(2875773) /Source="Nicolas_upshifts" /id="D1538" /incds=0 /nref=140 /ntot=248 /MaxReadThrough="1.89952" /MaxDrop="4.55096" /score="14.9571314" /energy="-14.4" /TU="NA" /idTUdmin="U2317" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2876849..2876868) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2876853) /Source="Nicolas_upshifts" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" promotor_-35 complement(2876882..2876889) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2876924..2876927 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2876942..2876961 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2876947 /Source="Nicolas_upshifts" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" CDS 2876986..2877303 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390865.1" /db_xref="EnsemblGenomes-Gn:BSU29870" /db_xref="EnsemblGenomes-Tr:CAB14965" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13936" /db_xref="UniProtKB/Swiss-Prot:O32065" /translation="MKLRHLLLGAGLGICTAVVVRQYVMKPYISSEKALRIVKSAFKQ RGPIDGSWIYTQPEPYNINGETVQVYKTGITRSAFGELEQYEVMVDAKTGEIVDVIDT IAS*" gene 2876986..2877303 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" downshifts 2877303 /Source="Nicolas_upshifts" /id="D1539" /incds=0 /nref=250 /ntot=259 /MaxReadThrough="1.29231" /MaxDrop="7.83082" /score="44.9062865" /energy="-17" /TU="NA" /idTUdmin="U2318" /TUdmin=0 /isTUend="TRUE" CDS complement(2877356..2879056) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 20933603, 22740702, 23136871, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_390866.1" /db_xref="EnsemblGenomes-Gn:BSU29880" /db_xref="EnsemblGenomes-Tr:CAB14966" /db_xref="GOA:O34389" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG12614" /db_xref="UniProtKB/Swiss-Prot:O34389" /translation="MKQFRVTNEGDIQTTLRGLEVLSVPFLNKGVAFTEEERKELGLK GFLPPKVLTIDDQAKRAYEQYSAQPDDLSKNVYLTALHDRNETLFYRLLNDHLGEMLP IVYTPTVGTAIQRYSHEYRKPRGLYLSIDDPDGMKEAFKQYKDQSDTIDLIVATDAEG ILGIGDWGVGGIAISIGKLAVYTAAAGIDPSRVLAVVLDAGTNQESLLNDPLYVGNQH SRVRGERYDQFIDDYVALARETFPNALLHWEDFGAKNARSILKRYKDKVCTFNDDIQG TGAVSLAAVLSCAKASKVPLRDHRVVIFGAGTAGIGIAEQLREALVREGLSEEESYKR FWCIDRNGLLTDDMDQLLDFQKPYARSADEVKDYQRNGDGGGIDLLEVVRQAKPTILI GTSTVSGAFTEEIVKEMASHVKRPAILPMSNPTTLSEAKPEDLIEWTEGRALITTGSP FPPVEYNGVTYHIGQANNALVFPGLGLGTIVTKSKLITDGMFEACARAIAGMVNVGVP GAPMLPKVEDLRTVSATVAVEVAKTAMKEGVATEEPEDIIQAVQDAMWYPVYKPIRAI *" gene complement(2877356..2879056) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" downshifts complement(2877375) /Source="Nicolas_upshifts" /id="D1540" /incds=0 /nref=77 /ntot=255 /MaxReadThrough="2.4872" /MaxDrop="4.99085" /score="17.675308" /energy="-15.3" /TU="NA" /idTUdmin="U2319" /TUdmin="-18" /isTUend="TRUE" promotor_-10 complement(2879088..2879106) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2879095) /Source="Nicolas_upshifts" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" promotor_-35 complement(2879121..2879127) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2879138..2879908) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22101040, 24268182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative quorum-quenching lactonase" /protein_id="NP_390867.1" /db_xref="EnsemblGenomes-Gn:BSU29890" /db_xref="EnsemblGenomes-Tr:CAB14967" /db_xref="GOA:O34760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13895" /db_xref="UniProtKB/Swiss-Prot:O34760" /translation="MFGVVPKPLWSKKYPVNEKNQIELRTDPILIQKDGLNIIIDAGI GYGKLTDKQKRNYGVTQESNVKPSLAALGLTVADIDVIAMTHLHFDHACGLTEYEGER LVSVFPNAVIYTSAVEWDEMRHPNIRSKNTYWKENWEAVAGQVKTFEDTLTITEGITM HHTGGHSDGHSVLICEDAGETAVHMADLMPTHAHRNPLWVLAYDDYPMTSIPQKQKWQ AFAAEKDAWFIFYHDAEYRALQWEEDGSIKKSVKRMKR*" gene complement(2879138..2879908) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" S_feature complement(2879909..2879997) /Source="Nicolas_S_feature" /locus_tag="new_3059402_3059490_c" /HighExp="HiOs, M40t90, T0.30H, T1.30H, T3.0H, T1.0H, Sw, T2.30H, T3.30H, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1145" promotor_-10 complement(2879995..2880014) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2879997) /Source="Nicolas_upshifts" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" promotor_-35 complement(2880030..2880034) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2880054..2880695) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" /EC_number="2.1.1.33" /function="16.6: Maintain" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15789416, 16600901, 17150909, 19934251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15789416, 16600901, 17150909, 19934251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (guanine-N(7)-)-methyltransferase" /protein_id="NP_390868.1" /db_xref="EnsemblGenomes-Gn:BSU29900" /db_xref="EnsemblGenomes-Tr:CAB14968" /db_xref="GOA:O34522" /db_xref="InterPro:IPR003358" /db_xref="InterPro:IPR029063" /db_xref="PDB:2FCA" /db_xref="SubtiList:BG13890" /db_xref="UniProtKB/Swiss-Prot:O34522" /translation="MRMRHKPWADDFLAENADIAISNPADYKGKWNTVFGNDNPIHIE VGTGKGQFISGMAKQNPDINYIGIELFKSVIVTAVQKVKDSEAQNVKLLNIDADTLTD VFEPGEVKRVYLNFSDPWPKKRHEKRRLTYSHFLKKYEEVMGKGGSIHFKTDNRGLFE YSLKSFSEYGLLLTYVSLDLHNSNLEGNIMTEYEEKFSALGQPIYRAEVEWRT*" gene complement(2880054..2880695) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" downshifts complement(2880064) /Source="Nicolas_upshifts" /id="D1541" /incds=0 /nref=46 /ntot=131 /MaxReadThrough="3.31031" /MaxDrop="5.64644" /score="29.2137061" /energy="-10.1" /TU="NA" /idTUdmin="U2321" /TUdmin="-1" /isTUend="TRUE" downshifts complement(2880129) /Source="Nicolas_upshifts" /id="D1542" /incds=1 /nref=39 /ntot=202 /MaxReadThrough="6.31908" /MaxDrop="3.64275" /score="29.2137061" /energy="-10.1" /TU="U2321,U2323" /idTUdmin="U2323" /TUdmin="-44" /isTUend="FALSE" promotor_-10 complement(2880721..2880740) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2880730) /Source="Nicolas_upshifts" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" S_feature complement(2880732..2881180) /Source="Nicolas_S_feature" /locus_tag="new_3060225_3060673_c" /HighExp="C30, Cold, G135, G180, B60, Paraq, G150, Oxctl, H2O2, LBGstat" /AntisenseName="ytzH" /AntisenseCor="-0.51149457663808795" /AntisenseRegPval="-18.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1146" promotor_-35 complement(2880756..2880760) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2880839..2880845 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2880860..2880871 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2880867 /Source="Nicolas_upshifts" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" CDS 2880902..2881180 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390869.1" /db_xref="EnsemblGenomes-Gn:BSU29910" /db_xref="EnsemblGenomes-Tr:CAB14969" /db_xref="InterPro:IPR025547" /db_xref="SubtiList:BG13942" /db_xref="UniProtKB/Swiss-Prot:O32066" /translation="MGLHYEHQVHLLKDILTDHQLDCCGTVAEYEQLERVIKSLMANT ELDSNFKNVLEDVYRYSQSGISSKSIDSHIQEHQNSLSQWVEQMDSYS*" gene 2880902..2881180 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" S_feature 2881181..2881351 /Source="Nicolas_S_feature" /locus_tag="new_3060674_3060844" /HighExp="S5, S7, S8, S6, S4, BT, C30, nit, ferm, G/S" /AntisenseName="ytmP" /AntisenseCor="-0.32108027439793901" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1147" CDS complement(2881181..2881795) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9026440, 11545674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase/phosphotransferase" /protein_id="NP_390870.2" /db_xref="EnsemblGenomes-Gn:BSU29920" /db_xref="EnsemblGenomes-Tr:CAB14970" /db_xref="GOA:C0SPC1" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG13889" /db_xref="UniProtKB/Swiss-Prot:C0SPC1" /translation="MENGDVITAQHWMTGRELKPKDMSGRPVAELLRKIHTSKALLDM LKRLGKEPLNPGALLSQLKQAVFAVQQSSPLIQEGIKYLEEHLHEVHFGEKVVCHCDV NHNNWLLSEDNQLYLIDWDGAMIADPAMDLGPLLYHYVEKPAWESWLSMYGIELTESL RLRMAWYVLSETITFIAWHKAKGNDKEFHDAMEELHILMKRIVD*" gene complement(2881181..2881795) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" downshifts 2881329 /Source="Nicolas_upshifts" /id="D1543" /incds=1 /nref=4 /ntot=35 /MaxReadThrough="2.54837" /MaxDrop="3.82368" /score="-4.89809956" /energy="-11.3" /TU="NA" /idTUdmin="U2322" /TUdmin=0 /isTUend="TRUE" S_feature complement(2881796..2882131) /Source="Nicolas_S_feature" /locus_tag="new_3061289_3061624_c" /HighExp="T1.30H, M9-stat, T2.30H, T3.0H, UNK1, B60, T2.0H, T3.30H, T1.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1148" promotor_-10 complement(2882123..2882142) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2882131) /Source="Nicolas_upshifts" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" promotor_-35 complement(2882157..2882164) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2882158..2884314) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" /EC_number="3.2.1.41" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9453151, 16582490, 19465663, 23973973" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9453151, 16582490, 19465663, 23973973; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pullulanase" /protein_id="NP_390871.2" /db_xref="EnsemblGenomes-Gn:BSU29930" /db_xref="EnsemblGenomes-Tr:CAB14971" /db_xref="GOA:C0SPA0" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR011840" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="PDB:2E8Y" /db_xref="PDB:2E8Z" /db_xref="PDB:2E9B" /db_xref="SubtiList:BG12566" /db_xref="UniProtKB/Swiss-Prot:C0SPA0" /translation="MVSIRRSFEAYVDDMNIITVLIPAEQKEIMTPPFRLETEITDFP LAVREEYSLEAKYKYVCVSDHPVTFGKIHCVRASSGHKTDLQIGAVIRTAAFDDEFYY DGELGAVYTADHTVFKVWAPAATSAAVKLSHPNKSGRTFQMTRLEKGVYAVTVTGDLH GYEYLFCICNNSEWMETVDQYAKAVTVNGEKGVVLRPDQMKWTAPLKPFSHPVDAVIY ETHLRDFSIHENSGMINKGKYLALTETDTQTANGSSSGLAYVKELGVTHVELLPVNDF AGVDEEKPLDAYNWGYNPLHFFAPEGSYASNPHDPQTRKTELKQMINTLHQHGLRVIL DVVFNHVYKRENSPFEKTVPGYFFRHDECGMPSNGTGVGNDIASERRMARKFIADCVV YWLEEYNVDGFRFDLLGILDIDTVLYMKEKATKAKPGILLFGEGWDLATPLPHEQKAA LANAPRMPGIGFFNDMFRDAVKGNTFHLKATGFALGNGESAQAVMHGIAGSSGWKALA PIVPEPSQSINYVESHDNHTFWDKMSFALPQENDSRKRSRQRLAAAIILLAQGVPFIH SGQEFFRTKQGVENSYQSSDSINQLDWDRRETFKEDVHYIRRLISLRKAHPAFRLRSA ADIQRHLECLTLKEHLIAYRLYDLDEVDEWKDIIVIHHASPDSVEWRLPNDIPYRLLC DPSGFQEDPTEIKKTVAVNGIGTVILYLASDLKSFA*" gene complement(2882158..2884314) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" CDS complement(2884340..2885269) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" /EC_number="2.7.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospholipid kinase" /protein_id="NP_390872.1" /db_xref="EnsemblGenomes-Gn:BSU29940" /db_xref="EnsemblGenomes-Tr:CAB14972" /db_xref="GOA:O34799" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13880" /db_xref="UniProtKB/Swiss-Prot:O34799" /translation="MSHWFFIINPTAGHRNGLRVWKSIQKELIKRKVEHRSFLTEHPG HAEVLARQISTIQEYKLKRLIVIGGDGTMHEVVNGLKDVDDIELSFVPAGAYNDFSRG FSIKKIDLIQEIKKVKRPLTRTFHLGSVNFLQDKSQILYFMNHIGIGFDAYVNKKAME FPLRRVFLFLRLRFLVYPLSHLHASATFKPFTLACTTEDETREFHDVWFAVVSNHPFY GGGMKAAPLANPREKTFDIVIVENQPFLKKYWLLCLMAFGKHTKMDGVTMFKAKDITF YTKDKIPFHADGEIMGTTPFRLASSPSPLRIKT*" gene complement(2884340..2885269) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" CDS complement(2885318..2886232) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390873.1" /db_xref="EnsemblGenomes-Gn:BSU29950" /db_xref="EnsemblGenomes-Tr:CAB14973" /db_xref="InterPro:IPR012397" /db_xref="SubtiList:BG13879" /db_xref="UniProtKB/Swiss-Prot:O34471" /translation="MAQIIKIHDYISRYELDPYHYINQFVRLKKERWLSLVEAAERQH EERQASAEEPEPVQKRKKFSLKRRKEEIKADIQEERHQWFEDEEDIHVRLPKSRVALA SFYKRHLYDFQLKWASSTLSEISQLSNQVKQDRILRYLTQQLPDSYFIMYKPVLKIQQ AAVELSIVIISPLEIYCVSFLEAEEDSVYIGSKNRFWDKKTASQTASVLNPGLSLFRT DSVVSKIVKEKQAEIPVRKLLLSRTSYIDYPEPPYGLEIADKRSAEEWIERQKKNTAP IKHHQVKAAKALLSYCMSDSYRRQEWLE*" gene complement(2885318..2886232) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" promotor_-10 complement(2885995..2886013) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2886003) /Source="Nicolas_upshifts" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" promotor_-35 complement(2886027..2886033) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" CDS complement(2886258..2886809) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" /EC_number="3.1.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17012785; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA 2',3'-cyclic phosphodiesterase" /protein_id="NP_390874.1" /db_xref="EnsemblGenomes-Gn:BSU29960" /db_xref="EnsemblGenomes-Tr:CAB14974" /db_xref="GOA:O34570" /db_xref="InterPro:IPR004175" /db_xref="InterPro:IPR009097" /db_xref="SubtiList:BG13878" /db_xref="UniProtKB/Swiss-Prot:O34570" /translation="MPDIRPHYFIGVPIPEGIANPIYQAAKNEPILTFQKWVHPLDYH ITLIFLGAADETQIKKLEGSLAEIASEIDPFSIKFGKIDVFGDRRKPRVLHLEPKKNK TLDRLREHTKQAVLQAGFQVEKRPYHPHMTLARKWTGEDGFPAHVPFESGEVSMMAER FSLFQIHLNQSPKYEEIFKFQLS*" gene complement(2886258..2886809) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" misc_feature 2886672..2886691 /Source="Nicolas_upshift_promotors" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2886675 /Source="Nicolas_upshifts" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2886832..2886851) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2886844) /Source="Nicolas_upshifts" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" promotor_-35 complement(2886867..2886870) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" promotor_-35 2886892..2886899 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2886910..2886929 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2886913..2886924) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2886917 /Source="Nicolas_upshifts" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" upshifts complement(2886927) /Source="Nicolas_upshifts" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" promotor_-35 complement(2886938..2886944) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2886958..2887893 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cysteine synthase-like enzyme" /protein_id="NP_390875.1" /db_xref="EnsemblGenomes-Gn:BSU29970" /db_xref="EnsemblGenomes-Tr:CAB14975" /db_xref="GOA:O34476" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG13872" /db_xref="UniProtKB/Swiss-Prot:O34476" /translation="MLKIVANTADLIGDTPLVRLNRLQPENAAQVYLKLEFFNPSGSV KDRAAYQMIIEAEQNGLLKPGSVIIEPTSGNTGIGLAMNAAARGYKAILVMPDTMTKE RINLLKAYGAEVVLTPGEERMPGSIKKAKELAEQIPNSYIPMQFDNTANPDAHRKTTA PEIARAIEEIGKPLGAFVASSGTGGTITGTGEALKELFPDITVHVVEPAGSPVLSGGK PGAHKLVGTSPGFIPPILNEDVYDEIIKISDEDAYTTTRRLAAEEGILVGPSSGAACF AAIETAKRLSPDKVVVCMTADTGERYLSTDLWSFI*" gene 2886958..2887893 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" downshifts 2887869 /Source="Nicolas_upshifts" /id="D1544" /incds=0 /nref=74 /ntot=225 /MaxReadThrough="2.5873" /MaxDrop="4.59197" /score="29.2734118" /energy="-18.2" /TU="NA" /idTUdmin="U2327" /TUdmin="-16" /isTUend="TRUE" CDS complement(2887927..2889318) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" /EC_number="3.5.-.-" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7528082, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative promiscuous peptidase/deacylase" /protein_id="NP_390876.1" /db_xref="EnsemblGenomes-Gn:BSU29980" /db_xref="EnsemblGenomes-Tr:CAB14976" /db_xref="GOA:O34944" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010964" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13867" /db_xref="UniProtKB/Swiss-Prot:O34944" /translation="MNWEVEVIRKKEDLIRDTQEFLRINSVMDETTAGPGKPFGEGVN ASLTSLLELGEKEGFTTKNLDGFAGHIEWGEGDDIIGVLCHVDVVPPGDGWTSDPFSA EIRNGRIYARGAIDDKGPTMAAFYALKIVKDMNLPLSKRVRMIIGTDEESDWRCVEHY FKHEEMPTMGFAPDADFPIINAEKGIIDASLLIPHRPNQAEPKAVLVSFQSGLRLNMV PDAAEAVIEGPKNEEILSSFKDMLRTTDQKGEAAIENGQLILRMYGLSCHAMEPNNGI NAGILLCEFLQQTELDDAGKRFVQVVTDKFSGDTRGKKLDIDCEDEISGELTLNVGTL RYKEGQGGELGINIRYPVTAESKVIRDTFESASEFELGEFKDSKPHHVSADHPLVKTL QKVYEGQLGKKADLISIGGGTYARSLKAGVAFGPLFPGRPDSAHQKDEYIEIDDLLRS TALYAQAIYELAK*" gene complement(2887927..2889318) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" downshifts complement(2887939) /Source="Nicolas_upshifts" /id="D1545" /incds=0 /nref=63 /ntot=240 /MaxReadThrough="3.38616" /MaxDrop="3.73023" /score="23.9099234" /energy="-14.4" /TU="U2330" /idTUdmin="U2330" /TUdmin="-330" /isTUend="FALSE" S_feature complement(2889319..2889759) /Source="Nicolas_S_feature" /locus_tag="new_3068812_3069252_c" /HighExp="Etha, Salt, M40t90, Lbtran, T1.30H, M0t90, Lbstat, T1.0H, T0.30H, LBGstat" /AntisenseName="pbuO" /AntisenseCor="-0.324692399913451" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1149" promotor_-35 2889345..2889350 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2889364..2889383 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2889377 /Source="Nicolas_upshifts" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" CDS 2889415..2890713 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11591660, 12923093, 15849754, 16850406, 19446032, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12923093, 15849754, 16850406, 19446032, 28583948; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_390877.1" /db_xref="EnsemblGenomes-Gn:BSU29990" /db_xref="EnsemblGenomes-Tr:CAB14977" /db_xref="GOA:O34978" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG13864" /db_xref="UniProtKB/Swiss-Prot:O34978" /translation="MFHLKEQQTSIKQEIIAGLTTFFTMVYIVVVNPVILANAGVPFD QVFTATIIASIVGTLWMALAANYPIAIAPGMGLNAYLAFHVVSASDGGITYATAFSAV FTAGVLFIILSLTPLRKQLIEAIPNNLKYGITTGIGLFIAFIGLRQAGIVAADESNLV TLGNLHSPGVILTLVGLLISVVLMVLNVSGALFIGMAATALIAFFTGQLHFSKGFMSL PHLPEGLMISNPFTAFGDVIHHGLYAVVFSFLLVTIFDTTGTMIGVAEQAGLMKNNKL PNVRKALLADSTATTVGAVFGTSPTTAFIESSAGVAAGGRTGLTALTVAVMFAASMFF SPLVSALSGIAAITSPALIIVGSLMMGSVSNMNWKEMDEAFPAFLVILAMPLTSSIST GIALGFISYPIVKAARGKWREIHPLVIVFAILFFIQLFIL*" gene 2889415..2890713 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" promotor_-10 complement(2889736..2889755) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2889759) /Source="Nicolas_upshifts" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" promotor_-35 complement(2889770..2889776) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2890700 /Source="Nicolas_upshifts" /id="D1546" /incds=0 /nref=43 /ntot=178 /MaxReadThrough="2.37859" /MaxDrop="5.35341" /score="16.9979166" /energy="-10.2" /TU="NA" /idTUdmin="U2329" /TUdmin="-1" /isTUend="TRUE" CDS complement(2890753..2891910) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390878.1" /db_xref="EnsemblGenomes-Gn:BSU30000" /db_xref="EnsemblGenomes-Tr:CAB14978" /db_xref="GOA:O35029" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG13861" /db_xref="UniProtKB/Swiss-Prot:O35029" /translation="MNGRTLFFRRLFDYYKYQFKVLHAVIDWTVALYIVLPAIAFVIY QYIDLMNGRGLLYEWSEVAEWRWLYAVCVLIMFTGSIRTFLMEADKVFLLQKKEIIYQ LKRYALLYSFLATLAKWLLLFFIVLPLISHSVLITFAESTALLCYLFGLHIFFLSLKQ DRIRKPRSISRWIGDTLVRAILFAGSAILIVFTERHLLALFGILFLFFSVIRSLKKTA SFTAFEAEVTEEKKSRLALAGLVMMMSQEAGMPKVKDRMRRKPLLYRNSKRIFKRRTI CTGYKELFFKVMLRNGEYARQMYMLLSAFTVLIFVSPIWLKVIALLVYTGVCRYILTL IFDKVMDAPFLIGTDKESDEYYRARKSCINILHYAFAACCFLAAAVSLLFT*" gene complement(2890753..2891910) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" downshifts complement(2890778) /Source="Nicolas_upshifts" /id="D1547" /incds=0 /nref=1 /ntot=153 /MaxReadThrough="3.07175" /MaxDrop="3.89104" /score="19.8243425" /energy="-11.2" /TU="NA" /idTUdmin="U2332" /TUdmin=0 /isTUend="TRUE" promotor_-35 2891026..2891031 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2891046..2891064 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2891054 /Source="Nicolas_upshifts" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2891907..2892617) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_390879.1" /db_xref="EnsemblGenomes-Gn:BSU30010" /db_xref="EnsemblGenomes-Tr:CAB14979" /db_xref="GOA:O34977" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13860" /db_xref="UniProtKB/Swiss-Prot:O34977" /translation="MTNLLEASIEQAGYTSRKKVLTDVFLEVRKGELVGLIGANGAGK STAIKAILGLSEDFKGHIAWNDCSFAYIPEHPSFYEELTLWEHLDLISTLHGIEESEF AHRAQSLLQTFSLDHVKHELPVTFSKGMQQKLMLIQAFLSKPDMYVIDEPFIGLDPIS TKRFVDMLKAEKERGAGILMCTHVLDTAEKICDRFYMIEKGSLFLQGTLKDVQDKTGL EGQSLLDCFYKAVQGDRL*" gene complement(2891907..2892617) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" promotor_-10 complement(2892631..2892646) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2892648) /Source="Nicolas_upshifts" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" promotor_-35 complement(2892658..2892667) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2892674..2892675 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2892687..2892792 /Source="Nicolas_S_feature" /locus_tag="new_3072180_3072285" /HighExp="S5, S4, S3, S8, S7, S6, G/S, Pyr, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1150" upshifts 2892687 /Source="Nicolas_upshifts" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" promotor_-10 2892695..2892705 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2892758..2892764 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2892779..2892798 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2892794..2892907 /Source="Nicolas_S_feature" /locus_tag="new_3072287_3072400" /HighExp="S4, S5, M0t90, S3, Etha, M9-stat, M40t90, LPhT, Heat, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1151" upshifts 2892794 /Source="Nicolas_upshifts" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" CDS 2892908..2893129 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618461; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (DeoR family)" /protein_id="NP_390880.1" /db_xref="EnsemblGenomes-Gn:BSU30020" /db_xref="EnsemblGenomes-Tr:CAB14980" /db_xref="GOA:O32067" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13939" /db_xref="UniProtKB/Swiss-Prot:O32067" /translation="MKPSTNRMLTRIKSVYMFIQEKGLVTTQELVDEFGITPRTIQRD LNVLAYNDLVHSPSRGKWETTRKKVKITS*" gene 2892908..2893129 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" downshifts 2893112 /Source="Nicolas_upshifts" /id="D1548" /incds=0 /nref=166 /ntot=259 /MaxReadThrough="4.38243" /MaxDrop="4.90218" /score="20.9755494" /energy="-13.5" /TU="U2333,U2334" /idTUdmin="U2333" /TUdmin="-54" /isTUend="FALSE" downshifts 2893181 /Source="Nicolas_upshifts" /id="D1549" /incds=0 /nref=44 /ntot=172 /MaxReadThrough="-0.189589999999999" /MaxDrop="6.00369" /score="20.9755494" /energy="-13.5" /TU="NA" /idTUdmin="U2334" /TUdmin="-7" /isTUend="TRUE" CDS complement(2893250..2893969) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" /EC_number="4.2.1.70" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11953756, 16511038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA pseudouridylate 516 synthase" /protein_id="NP_390882.2" /db_xref="EnsemblGenomes-Gn:BSU30035" /db_xref="EnsemblGenomes-Tr:CAB14982" /db_xref="GOA:O32068" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG13941" /db_xref="UniProtKB/Swiss-Prot:O32068" /translation="MRLDKLLANSGYGSRKEVKAVVKAGAVMIDGKPAKDVKEHVDPD TQEVTVYGEPVDYREFIYLMMNKPQGVLSATEDSRQQTVVDLLTPEEMRFEPFPAGRL DKDTEGFLLLTNDGQLAHRLLSPKKHVPKTYEVHLKSQISREDISDLETGVYIEGGYK TKPAKAEIKTNDSGNTVIYLTITEGKYHQVKQMAKAVGNEVVYLKRLSMGRVSLDPAL APGEYRELTEEELHLLNEPQA*" gene complement(2893250..2893969) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" downshifts complement(2893264) /Source="Nicolas_upshifts" /id="D1550" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="0.79865" /MaxDrop="2.6873" /score="21.6808891" /energy="-13.5" /TU="NA" /idTUdmin="U2335" /TUdmin=154 /isTUend="FALSE" downshifts complement(2894035) /Source="Nicolas_upshifts" /id="D1551" /incds=0 /nref=1 /ntot=76 /MaxReadThrough="4.50848" /MaxDrop="2.99899" /score="8.79816042" /energy="-9.5" /TU="U2335" /idTUdmin="U2335" /TUdmin="-617" /isTUend="FALSE" CDS complement(2894038..2895672) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_390883.1" /db_xref="EnsemblGenomes-Gn:BSU30050" /db_xref="EnsemblGenomes-Tr:CAB14983" /db_xref="GOA:O34674" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG13856" /db_xref="UniProtKB/Swiss-Prot:O34674" /translation="MSSKLLRGTFVLTLGTYISRILGMVYLIPFSIMVGATGGALFQY GYNQYTLFLNIATMGFPAAVSKFVSKYNSKGDYETSRKMLKAGMSVMLVTGMIAFFIL YLSAPMFAEISLGGKDNNGLTIDHVVYVIRMVSLALLVVPIMSLVRGFFQGHQMMGPT AVSQVVEQIVRIIFLLSATFLILKVFNGGLVIAVGYATFAALIGAFGGLVVLYIYWNK RKGSLLAMMPNTGPTANLSYKKMFFELFSYAAPYVFVGLAIPLYNYIDTNTFNKAMIE AGHQAISQDMLAILTLYVQKLVMIPVSLATAFGLTLIPTITESFTSGNYKLLNQQINQ TMQTILFLIIPAVVGISLLSGPTYTFFYGSESLHPELGANILLWYSPVAILFSLFTVN AAILQGINKQKFAVVSLVIGVVIKLVLNVPLIKLMQADGAILATALGYIASLLYGFIM IKRHAGYSYKILVKRTVLMLVLSAIMGIAVKIVQWVLGFFISYQDGQMQAAIVVVIAA AVGGAVYLYCGYRLGFLQKILGRRLPGFFRKGRHAG*" gene complement(2894038..2895672) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" misc_feature complement(2895704..2895723) /Source="Nicolas_upshift_promotors" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2895720) /Source="Nicolas_upshifts" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" promotor_-35 2895790..2895794 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2895810..2895829 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2895828 /Source="Nicolas_upshifts" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" CDS 2895874..2897136 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(FAD)-utilizing dehydrogenase" /protein_id="NP_390884.2" /db_xref="EnsemblGenomes-Gn:BSU30060" /db_xref="EnsemblGenomes-Tr:CAB14984" /db_xref="InterPro:IPR004792" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13850" /db_xref="UniProtKB/Swiss-Prot:Q795R8" /translation="MKQYDVIVIGGGPSGLMAAIAAGEQGAGVLLIDKGNKLGRKLAI SGGGRCNVTNRLPVEEIIKHIPGNGRFLYSAFSEFNNEDIIKFFENLGIQLKEEDHGR MFPVTDKAQSVVDALLNRLKQLRVTIRTNEKIKSVLYEDGQAAGIVTNNGEMIHSQAV IIAVGGKSVPHTGSTGDGYEWAEAAGHTITELFPTEVPVTSGEPFIKQKTLQGLSLRD VAVSVLNKKGKPIITHKMDMLFTHFGLSGPAILRCSQFVVKELKKQPQVPIRIDLYPD INEETLFQKMYKELKEAPKKTIKNVLKPWMQERYLLFLLEKNGISPNVSFSELPKDPF RQFVRDCKQFTVLANGTLSLDKAFVTGGGVSVKEIDPKKMASKKMEGLYFCGEILDIH GYTGGYNITSALVTGRLAGLNAGQYARS*" gene 2895874..2897136 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" S_feature 2897137..2897235 /Source="Nicolas_S_feature" /locus_tag="new_3076630_3076728" /HighExp="LBGstat, Lbstat, M0t90, T2.30H, T1.0H, T0.30H, BC, T2.0H, T1.30H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1152" promotor_-35 2897209..2897215 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2897231..2897249 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2897237..2897324 /Source="Nicolas_S_feature" /locus_tag="new_3076730_3076817" /HighExp="Etha, LBGstat, Salt, M9-stat, Lbstat, LBGtran, Sw, C30, Gly, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1153" upshifts 2897237 /Source="Nicolas_upshifts" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" CDS 2897325..2898863 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14996799, 15849754, 16850406, 8752321, 9925583" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14996799, 15849754, 16850406, 8752321, 9925583; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine transporter" /protein_id="NP_390885.1" /db_xref="EnsemblGenomes-Gn:BSU30070" /db_xref="EnsemblGenomes-Tr:CAB14985" /db_xref="GOA:P54417" /db_xref="InterPro:IPR000060" /db_xref="InterPro:IPR018093" /db_xref="SubtiList:BG11958" /db_xref="UniProtKB/Swiss-Prot:P54417" /translation="MLKHISSVFWIVIAITAAAVLWGVISPDSLQNVSQSAQAFITDS FGWYYLLVVSLFVGFCLFLIFSPIGKIKLGKPDEKPEFGLLSWFAMLFSAGMGIGLVF YGAAEPISHYAISSPSGETETPQAFRDALRYTFFHWGLHAWAIYAIVALCIAYFQFRK GAPGLISSTLSPILGDKVNGPIGKAIDCIAVFATVVGVSTSLGLGATQINGGLNYLFG IPNAFIVQLVLIIIVTVLFLLSAWSGLGKGIKYLSNTNMVLAGLLMLFMLVVGPTVLI MNSFTDSIGQYIQNIVQMSFRLTPNDPEKREWINSWTIFYWAWWISWSPFVGIFIARV SRGRTIREFLIGVLVTPCILTFLWFSIFGVSAMDLQQKGAFNVAKLSTETMLFGTLDH YPLTMVTSILALILIAVFFITSADSATFVLGMQTSYGSLNPANSVKLSWGIIQSAMAA VLLYSGGLAALQNTAILAALPFSIVILLMIASLYQSLSKERREIKKAEKLDKPRSPRV KKAY*" gene 2897325..2898863 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" downshifts 2898843 /Source="Nicolas_upshifts" /id="D1552" /incds=0 /nref=231 /ntot=263 /MaxReadThrough="2.0688" /MaxDrop="6.06429" /score="27.1497809" /energy="-16.3" /TU="NA" /idTUdmin="U2336" /TUdmin=0 /isTUend="TRUE" CDS complement(2898900..2899082) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8990290" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390886.1" /db_xref="EnsemblGenomes-Gn:BSU30080" /db_xref="EnsemblGenomes-Tr:CAB14986" /db_xref="GOA:P94496" /db_xref="InterPro:IPR020296" /db_xref="SubtiList:BG12339" /db_xref="UniProtKB/Swiss-Prot:P94496" /translation="MLKVAVFDEEHEKDLQTEINSFLKGISEEQLIDIKYTVSAACDP DGEQLYCFSALILYRK*" gene complement(2898900..2899082) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" downshifts complement(2898919) /Source="Nicolas_upshifts" /id="D1553" /incds=0 /nref=10 /ntot=61 /MaxReadThrough="0.597819999999999" /MaxDrop="4.78152" /score="32.507978" /energy="-16.3" /TU="NA" /idTUdmin="U2338" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2899097..2899115) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2899117) /Source="Nicolas_upshifts" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" promotor_-35 complement(2899131..2899136) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2899150..2899818) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme for rhamnogalaturonan degradation" /protein_id="NP_390887.1" /db_xref="EnsemblGenomes-Gn:BSU30090" /db_xref="EnsemblGenomes-Tr:CAB14987" /db_xref="GOA:O34378" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG13846" /db_xref="UniProtKB/Swiss-Prot:O34378" /translation="MEHDGSLGRMLRFCEWIMRFAYTNLLWLFFTLLGLGVFGIMPAT AALFAVMRKWIQGQDNVPVLKTFWQEYKGEFFRSNLLGAVLALIGVIIYIDLALIYPS HFLLHILRFAIMIFGFLFVSMLFYVFPLLVHFDWKKRLYVKFSLLLSVAYLQYTLTML ALTVALFFLLAYLPGIVPFFSVSLISYCHMRIVYAVLLKVEQHGGEPQRKSHIRKAFY PETR*" gene complement(2899150..2899818) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" CDS complement(2899840..2901126) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase of rhamnogalaturonan degradation" /protein_id="NP_390888.1" /db_xref="EnsemblGenomes-Gn:BSU30100" /db_xref="EnsemblGenomes-Tr:CAB14988" /db_xref="GOA:O34371" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13845" /db_xref="UniProtKB/Swiss-Prot:O34371" /translation="MKNIVFCGLSSRAFSMFIKPLMERFSTHYEITGLLDADPKRFAV CKKKFPELAHVPEFSEDAFDEMMRVSKPDIVIVAGRDDTHVAYIVKSLQWNTDVITEK PMVTTVQDANRVLEAEAKSEGKVTVAFNYRYSPFHRKIKEMILDGKIGRVTSVDLNWY IDTYHGASYFKRWNRSRQFSGGLSVHKSTHHFDLVNWWLGQNPEEVFAYGALNYYGPD SEWNPLPEEDGRFCGTCRVKEKCHYYSRWHPRSSKASIKDDHLEAGDQSSLYTAYRPD ACIFDEEIDIEDTYVAAVKYDGGALLSYSIIFSAPYEGYRLTINGTKGRIESNEFHEP SRIPFAFPEQTIEYYPLFESKQTIQVVKNEGGHGGGDPLLLEDLFLGKDPLRRYDILA GAEAGAYSIAVGEGMWRSVAEKKPIGMKELFQMQNV*" gene complement(2899840..2901126) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" CDS complement(2901138..2901641) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17449691, 23504016; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein required for rhamnogalaturonan transport and degradation" /protein_id="NP_390889.2" /db_xref="EnsemblGenomes-Gn:BSU30110" /db_xref="EnsemblGenomes-Tr:CAB14989" /db_xref="GOA:C0SP80" /db_xref="SubtiList:BG13844" /db_xref="UniProtKB/Swiss-Prot:C0SP80" /translation="MTKRIRTALCVIVSVLFLASCSSRPDGMHVILFSDMQAGVQEKI KKAAEQNAGKVDIFPAFQEKLLTEITAHEGDVFIVPEDMFQAYDDPENFQPLNGLPPE KTSPYTTVNKKTGEKTIYAVQIEKGKKQLNGYSFQLNRDMAAFIPVYAEKTEEALQLI SQLTEAR*" gene complement(2901138..2901641) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" CDS complement(2901638..2902759) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" /EC_number="3.2.1.172" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15148314, 15906318, 16781735, 16870154, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15148314, 15906318, 16781735, 16870154, 17449691, 23504016; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="unsaturated rhamnogalacturonyl hydrolase" /protein_id="NP_390890.3" /db_xref="EnsemblGenomes-Gn:BSU30120" /db_xref="EnsemblGenomes-Tr:CAB14990" /db_xref="GOA:O34559" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR010905" /db_xref="PDB:1NC5" /db_xref="PDB:2D8L" /db_xref="PDB:2GH4" /db_xref="SubtiList:BG13843" /db_xref="UniProtKB/Swiss-Prot:O34559" /translation="MGSMDQSIAVKSPLTYAEALANTIMNTYTVEELPPANRWHYHQG VFLCGVLRLWEATGEKRYFEYAKAYADLLIDDNGNLLFRRDELDAIQAGLILFPLYEQ TKDERYVKAAKRLRSLYGTLNRTSEGGFWHKDGYPYQMWLDGLYMGGPFALKYANLKQ ETELFDQVVLQESLMRKHTKDAKTGLFYHAWDEAKKMPWANEETGCSPEFWARSIGWY VMSLADMIEELPKKHPNRHVWKNTLQDMIKSICRYQDKETGLWYQIVDKGDRSDNWLE SSGSCLYMYAIAKGINKGYLDRAYETTLLKAYQGLIQHKTETSEDGAFLVKDICVGTS AGFYDYYVSRERSTNDLHGAGAFILAMTELEPLFRSAGK*" gene complement(2901638..2902759) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" CDS complement(2902767..2903732) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease for unsaturated rhamnogalacturonan" /protein_id="NP_390892.2" /db_xref="EnsemblGenomes-Gn:BSU30135" /db_xref="EnsemblGenomes-Tr:CAB14992" /db_xref="GOA:C0SPB3" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13841" /db_xref="UniProtKB/Swiss-Prot:C0SPB3" /translation="MKTAEAQAPAVDAVIFKKEKRKRLLIKLIQQKYLYLMILPGCIY FLLFKYVPMWGIVIAFQDYQPFLGILGSEWVGLKHFIRLFTEPTFFLLLKNTLVLFAL NLAIFFPVPILLALLLNEVRIALFKKFVQTLIYIPHFMSWVIVVSLSFVLLTVDGGLI NELIVFFGGEKINFLLNEEWFRPLYILQVIWREAGWSTIIYLAAITAVDPQLYEAAKM DGAGRLRQMWHITLPAIKSVIVVLLILKIGDTLELGFEHVYLLLNATNREVAEIFDTY VYTAGLKQGQFSYSTAVGVFKAAVGLILVMLANRLAKKFGEEGIY*" gene complement(2902767..2903732) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" upshifts complement(2903758) /Source="Nicolas_upshifts" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" promotor_-10 complement(2903759..2903778) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2903793..2903800) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2903888..2903895 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2903908 /Source="Nicolas_upshifts" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" promotor_-10 2903911..2903930 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2903948..2906266 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="membrane bound transcriptional regulator (controlling rhamnogalacturonan degradation)" /protein_id="NP_390893.1" /db_xref="EnsemblGenomes-Gn:BSU30150" /db_xref="EnsemblGenomes-Tr:CAB14993" /db_xref="GOA:O32071" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG13838" /db_xref="UniProtKB/Swiss-Prot:O32071" /translation="MGGFMKRSQYKFYYKLITFFCLLSTIPVILVGLFSYEHSQKTAI SNVSEEKFDTLQQTQQSIEHILKTVDHSLTHYVSSPPLLRTLSEPLHSDQFQIYNQVN QELNYLQSFDTDLSNMTLVSYTKKWYMNNSGLYRLNTDTLHEAASAYTKQKASRSYWT LEENNHLISTKEGTAENCRYNINLIKQLPLNSTNTKGLAAASIPSCSLVKNMPGYSNA NNLFIIDEKGLIILHNNMSDVGESLHNDGFVQKVLAQTANSGQFETVIDRIHYKVTYQ KSDYNAWTYFSLVSLPELKKEAKSIGWITFAVCLILLTLSLLFSWLGSRHFYKPIRVL YESFARHGAIQEKQQPPQNEFELIEQSFKQLKDRNDDLEETMKQQATHLQQYFMVRLM LGKLTDEEVDNRFESLGLKQNWRHLALLVLQIDTLNHTPYEKKDMDLLLFAVNSLIER NIPTDKHLAPAVVDKQQATILINQSGTKEEFMAELNETARMIQEKAEAELQLSVSIGI SQPFDVLTKAKTAYAEGSEALKYRLKAENKSIIFYEDLDQKKTFKTHFPKQLQHELFD AVKAGDKEKADKCLHAILQAIFTQNTNPYQFQIAIARFLNHVIELMHVLGIELFELEE NKMLYDQIFELKTFEDTENWLKNEFIDPMTDKVNARADAQYKNISDNIIHIIHHEFES ELTLDEIARRLHYNPNYLSSIFKKEMGISFSEYVSSYRHHMAKSWLAETDMAVKDIAE KLKYKNSQNFIRSFKKLEGITPGNYRQQKRSM*" gene 2903948..2906266 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" downshifts 2906256 /Source="Nicolas_upshifts" /id="D1554" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="1.43431" /MaxDrop="3.6268" /score="-7.37324741" /energy="-10.2" /TU="NA" /idTUdmin="U2340" /TUdmin=1870 /isTUend="FALSE" CDS complement(2906307..2907803) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_390894.3" /db_xref="EnsemblGenomes-Gn:BSU30160" /db_xref="EnsemblGenomes-Tr:CAB14994" /db_xref="GOA:Q795R2" /db_xref="SubtiList:BG13836" /db_xref="UniProtKB/Swiss-Prot:Q795R2" /translation="MGNKWRVLLIVLVLALGGVLAGCKGTDQSSAEGKAGPDSKVKLS WMAILYHQQPPKDRAIKEIEKLTNTELDITWVPDAVKEDRLNAALAAGNLPQIVTIQD IKNSSVMNAFRSGMFWEIGDYIKDYPNLNKMNKLINKNVTIDGKLYGIYRERPLSRQG IVIRKDWLDNLNLKTPKTLDELYEVAKAFTEDDPDKDGKDDTFGLADRNDLIYGAFKT IGSYEGMPTDWKESGGKFTPDFMTQEYKDTMNYMKKLRDNGYMNKDFPVTSKTQQQEL FSQGKAGIYIGNMVDAVNLRDHASDKSMKLEIINRIKGPDGKERVWASGGHNGVFAFP KTSVKTEAELKRILAFFDRIAEEDVYSLMTYGIDGVHYNKGEDKTFTRKESQVKDWQT DIQPLSALIAIDKAYLKNTGDPLRTAYEELTEDNEKIIVSNPAESLYSASESERGDEL KKIIDDATYKYMIGDITESQFDKEVEKWESSGGKQIIQEYEEAFKQAK*" gene complement(2906307..2907803) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" downshifts complement(2906309) /Source="Nicolas_upshifts" /id="D1555" /incds=0 /nref=26 /ntot=160 /MaxReadThrough="-0.0485899999999999" /MaxDrop="5.21039" /score="6.31011081" /energy="-11.2" /TU="NA" /idTUdmin="U2341" /TUdmin=1 /isTUend="TRUE" CDS complement(2907828..2908688) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390895.1" /db_xref="EnsemblGenomes-Gn:BSU30170" /db_xref="EnsemblGenomes-Tr:CAB14995" /db_xref="GOA:P53561" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11788" /db_xref="UniProtKB/Swiss-Prot:P53561" /translation="MKNRLFDMLIYGFLLMFALICVLPFIHVIAASFATVEEVVSKKF ILIPTTFSLDAYRYIFSTDIIYKSLLVSVFVTVIGTAVSMFLSSLMAYGLSRRDLIGR QPLMFLVVFTMLFSGGMIPTFLVVKSLGLLDSYWALILPTAINAFNLIILKNFFQNIP SSLEESAKIDGCNDLGIFFKIVLPLSLPAIATISLFYAVTYWNTYMTAILYLNDSAKW PIQVLLRQIVIVSSGMQGDMSEMGSGSPPPEQTIKMAVIVVATIPVLLVYPFIQKHFA KGALLGSVKG*" gene complement(2907828..2908688) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" promotor_-10 complement(2908764..2908783) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2908773) /Source="Nicolas_upshifts" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" promotor_-35 complement(2908799..2908806) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2908895..2909656) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-dependent nucleoside-diphosphate-sugar epimerase" /protein_id="NP_390896.2" /db_xref="EnsemblGenomes-Gn:BSU30180" /db_xref="EnsemblGenomes-Tr:CAB14996" /db_xref="GOA:P53560" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11787" /db_xref="UniProtKB/Swiss-Prot:P53560" /translation="MKKVLIAGGNGVIGRLLAEGLISDYEVTVLDKDHFDGKASSIQA DAANYEELLKKIPKDTDAILNLLAVKIKYDIMDIAEFEKMTDVFYRASYYLCRAAAEL GIQKLVFASSNHVTDVYEKDGRSLLGREITTSDYPLSKNLYGVLKLTSEQIGHLFYLE NKLSVINLRIGTVVTDEMDTLHEKERTKKTLLSHPDLLSIFKAAIETNIRYGTYYAVS DNPGRPWSIESAVNELGFSPQINTAELLNEEENGA*" gene complement(2908895..2909656) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" downshifts complement(2908924) /Source="Nicolas_upshifts" /id="D1556" /incds=0 /nref=153 /ntot=196 /MaxReadThrough="1.18543" /MaxDrop="5.85654" /score="12.3836957" /energy="-11.1" /TU="NA" /idTUdmin="U2344" /TUdmin="-19" /isTUend="TRUE" S_feature complement(2909657..2909732) /Source="Nicolas_S_feature" /locus_tag="new_3089150_3089225_c" /HighExp="LPh, HPh, aero, Gly, HiOs, BMM, GM-0.1, GM 10, GM 15, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1154" CDS complement(2909733..2910920) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" /EC_number="1.14.14.46" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 for pimelic acid formation for biotin biosynthesis" /protein_id="NP_390897.1" /db_xref="EnsemblGenomes-Gn:BSU30190" /db_xref="EnsemblGenomes-Tr:CAB14997" /db_xref="GOA:P53554" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:3EJB" /db_xref="PDB:3EJD" /db_xref="PDB:3EJE" /db_xref="SubtiList:BG11528" /db_xref="UniProtKB/Swiss-Prot:P53554" /translation="MTIASSTASSEFLKNPYSFYDTLRAVHPIYKGSFLKYPGWYVTG YEETAAILKDARFKVRTPLPESSTKYQDLSHVQNQMMLFQNQPDHRRLRTLASGAFTP RTTESYQPYIIETVHHLLDQVQGKKKMEVISDFAFPLASFVIANIIGVPEEDREQLKE WAASLIQTIDFTRSRKALTEGNIMAVQAMAYFKELIQKRKRHPQQDMISMLLKGREKD KLTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPDLIGTAVEECL RYESPTQMTARVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVFDITRSPNP HLSFGHGHHVCLGSSLARLEAQIAINTLLQRMPSLNLADFEWRYRPLFGFRALEELPV TFE*" gene complement(2909733..2910920) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" CDS complement(2910989..2911996) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" /EC_number="2.8.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin synthase" /protein_id="NP_390898.1" /db_xref="EnsemblGenomes-Gn:BSU30200" /db_xref="EnsemblGenomes-Tr:CAB14998" /db_xref="GOA:P53557" /db_xref="InterPro:IPR002684" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010722" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024177" /db_xref="SubtiList:BG11525" /db_xref="UniProtKB/Swiss-Prot:P53557" /translation="MNQWMELADRVLAGAEVTDEEALSILHCPDEDILLLMHGAFHIR KHFYGKKVKLNMIMNAKSGLCPENCGYCSQSAISKAPIESYRMVNKETLLEGAKRAHD LNIGTYCIVASGRGPSNREVDQVVDAVQEIKETYGLKICACLGLLKPEQAKRLKDAGV DRYNHNLNTSQRNHSNITTSHTYDDRVNTVEIAKESGLSPCSGAIIGMKETKQDVIDI AKSLKALDADSIPVNFLHAIDGTPLEGVNELNPLYCLKVLALFRFINPSKEIRISGGR EVNLRTLQPLGLYAANSIFVGDYLTTAGQEETEDHKMLSDLGFEVESVEEMKASLSAK S*" gene complement(2910989..2911996) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" CDS complement(2911999..2912694) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" /EC_number="6.3.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242, 20565114" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242, 20565114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dethiobiotin synthetase" /protein_id="NP_390899.1" /db_xref="EnsemblGenomes-Gn:BSU30210" /db_xref="EnsemblGenomes-Tr:CAB14999" /db_xref="GOA:P53558" /db_xref="InterPro:IPR004472" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11526" /db_xref="UniProtKB/Swiss-Prot:P53558" /translation="MRGFFVTGTDTEVGKTVISSGLAALLKDNNRHVGVYKPFLSGIS RHHPDSDTSLLKDMSQTSLSHEDITPFAFKAPLAPYVAGKLEGKTVTMEEVLSHWGRI REKHECFIVEGAGGISVPLGEDYLVSHVIKALQLPMIIVARPRLGTINHTFLTVKYAE SMGLPIAGIIINGISDSPDEDEKTNPEMIERLCGVPILGVTPKLANVTKETVLHMVKD HINLSLLMNQVGV*" gene complement(2911999..2912694) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" CDS complement(2912691..2913860) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11322938, 11717296, 12368242, 15056910, 16557306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11322938, 11717296, 12368242, 15056910, 16557306; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="8-amino-7-oxononanoate synthase (pimeloyl-CoA-dependent)" /protein_id="NP_390900.1" /db_xref="EnsemblGenomes-Gn:BSU30220" /db_xref="EnsemblGenomes-Tr:CAB15000" /db_xref="GOA:P53556" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11527" /db_xref="UniProtKB/Swiss-Prot:P53556" /translation="MKIDSWLNERLDRMKEAGVHRNLRSMDGAPVPERNIDGENQTVW SSNNYLGLASDRRLIDAAQTALQQFGTGSSGSRLTTGNSVWHEKLEKKIASFKLTEAA LLFSSGYLANVGVLSSLPEKEDVILSDQLNHASMIDGCRLSKADTVVYRHIDMNDLEN KLNETQRYQRRFIVTDGVFSMDGTIAPLDQIISLAKRYHAFVVVDDAHATGVLGDSGQ GTSEYFGVCPDIVIGTLSKAVGAEGGFAAGSAVFIDFLLNHARTFIFQTAIPPASCAA AHEAFNIIEASREKRQLLFSYISMIRTSLKNMGYVVKGDHTPIIPVVIGDAHKTVLFA EKLQGKGIYAPAIRPPTVAPGESRIRITITSDHSMGDIDHLLQTFHSIGKELHII*" gene complement(2912691..2913860) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" promotor_-35 2912727..2912734 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2912749..2912768 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2912767 /Source="Nicolas_upshifts" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2913850..2915196) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" /EC_number="2.6.1.105" /function="4.1: Biotin" /experiment="publication(s) with functional evidences, PMID:15880481, 20565114, 21437340" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15880481, 20565114, 21437340; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lysine-8-amino-7-oxononanoate aminotransferase" /protein_id="NP_390901.1" /db_xref="EnsemblGenomes-Gn:BSU30230" /db_xref="EnsemblGenomes-Tr:CAB15001" /db_xref="GOA:P53555" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR005815" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3DOD" /db_xref="PDB:3DRD" /db_xref="PDB:3DU4" /db_xref="SubtiList:BG11524" /db_xref="UniProtKB/Swiss-Prot:P53555" /translation="MTHDLIEKSKKHLWLPFTQMKDYDENPLIIESGTGIKVKDINGK EYYDGFSSVWLNVHGHRKKELDDAIKKQLGKIAHSTLLGMTNVPATQLAETLIDISPK KLTRVFYSDSGAEAMEIALKMAFQYWKNIGKPEKQKFIAMKNGYHGDTIGAVSVGSIE LFHHVYGPLMFESYKAPIPYVYRSESGDPDECRDQCLRELAQLLEEHHEEIAALSIES MVQGASGMIVMPEGYLAGVRELCTTYDVLMIVDEVATGFGRTGKMFACEHENVQPDLM AAGKGITGGYLPIAVTFATEDIYKAFYDDYENLKTFFHGHSYTGNQLGCAVALENLAL FESENIVEQVAEKSKKLHFLLQDLHALPHVGDIRQLGFMCGAELVRSKETKEPYPADR RIGYKVSLKMRELGMLTRPLGDVIAFLPPLASTAEELSEMVAIMKQAIHEVTSLED*" gene complement(2913850..2915196) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" promotor_-35 2914266..2914270 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2914285 /Source="Nicolas_upshifts" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2914286..2914304 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2915186..2915962) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" /EC_number="6.2.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11368323, 11717296, 21437340, 28196402, 29054876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11368323, 11717296, 21437340, 28196402, 29054876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-carboxyhexanoate-CoA ligase (pimeloyl-CoA synthase)" /protein_id="NP_390902.3" /db_xref="EnsemblGenomes-Gn:BSU30240" /db_xref="EnsemblGenomes-Tr:CAB15002" /db_xref="GOA:P53559" /db_xref="InterPro:IPR005499" /db_xref="PDB:5FLG" /db_xref="PDB:5FLL" /db_xref="PDB:5FM0" /db_xref="PDB:5G1F" /db_xref="SubtiList:BG11529" /db_xref="UniProtKB/Swiss-Prot:P53559" /translation="MQEETFYSVRMRASMNGSHEDGGKHISGGERLIPFHEMKHTVNA LLEKGLSHSRGKPDFMQIQFEEVHESIKTIQPLPVHTNEVSCPEEGQKLARLLLEKEG VSRDVIEKAYEQIPEWSDVRGAVLFDIHTGKRMDQTKEKGVRVSRMDWPDANFEKWAL HSHVPAHSRIKEALALASKVSRHPAVVAELCWSDDPDYITGYVAGKKMGYQRITAMKE YGTEEGCRVFFIDGSNDVNTYIHDLEKQPILIEWEEDHDS*" gene complement(2915186..2915962) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" S_feature complement(2915963..2916055) /Source="Nicolas_S_feature" /locus_tag="new_3095456_3095548_c" /HighExp="T-5.40H, GM 60, LPh, GM 25, HPh, MG 120, M9-exp, BMM, GM 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1155" promotor_-10 complement(2916041..2916060) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2916055) /Source="Nicolas_upshifts" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" promotor_-35 complement(2916075..2916082) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2916172..2917071) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390903.1" /db_xref="EnsemblGenomes-Gn:BSU30250" /db_xref="EnsemblGenomes-Tr:CAB15003" /db_xref="GOA:O34973" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11786" /db_xref="UniProtKB/Swiss-Prot:O34973" /translation="MRAERRKQLFRLLGDLPDRRPISVETLRIEEREENIVETLLLDL NGHEKAPAYFVKPKKTEGPCPAVLFQHSHGGQYDRGKSELIEGADYLKTPSFSDELTS LGYGVLAIDHWGFGDRRGKAESEIFKEMLLTGKVMWGMMIYDSLSALDYMQSRSDVQP DRIGTIGMSMGGLMAWWTAALDDRIKVCVDLCSQVDHHVLIKTQNLDRHGFYYYVPSL AKHFSASEIQSLIAPRPHLSLVGVHDRLTPAEGVDKIEKELTAVYAGQGAADCYRVVR SASGHFETAVIRHEAVRFLQKWL*" gene complement(2916172..2917071) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" promotor_-10 complement(2917094..2917112) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2917111) /Source="Nicolas_upshifts" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2917123..2917131) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2917201..2917208 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2917224..2917243 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2917230 /Source="Nicolas_upshifts" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" CDS 2917289..2918323 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12847288; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_390904.1" /db_xref="EnsemblGenomes-Gn:BSU30260" /db_xref="EnsemblGenomes-Tr:CAB15004" /db_xref="GOA:O34829" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12626" /db_xref="UniProtKB/Swiss-Prot:O34829" /translation="MVRIKDIALKAKVSSATVSRILNEDESLSVAGETRQRVINIAEE LGYQTVAKRRKSRGQKQRAQPLIGVLSCLSPDQERQDPYFSSIRKGIEKECFEQEIFI TNSIHLGSFQEHIFRELDGVIVIGRVHDEAVKHISGRLEHAVFINHSPDPQAYDSIGI DFESASRQAIDHLFDLGYKRLGYIGGQEKEHTLKDGQSIRRTIEDKRLTAFLESAAPQ PEHVLIGEYSMREGYRLMKKAIDQGHLPEAFFIASDSMAIGALKALQEAGLQVPRDTA IVSFNGIEEAEFASTPLTTVKVYTEEMGRTGVKLLLDRLNGRTLPQHVTLPTTLIVRQ SCGCTAKEVT*" gene 2917289..2918323 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" promotor_-35 2918272..2918279 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2918294..2918302 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2918311 /Source="Nicolas_upshifts" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" CDS 2918357..2919637 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8449892, 12847288, 16707683, 18954360, 28036052; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="multiple sugar-binding lipoprotein" /protein_id="NP_390905.1" /db_xref="EnsemblGenomes-Gn:BSU30270" /db_xref="EnsemblGenomes-Tr:CAB15005" /db_xref="GOA:O34335" /db_xref="InterPro:IPR006059" /db_xref="PDB:4R6H" /db_xref="SubtiList:BG12625" /db_xref="UniProtKB/Swiss-Prot:O34335" /translation="MKHTFVLFLSLILLVLPGCSAEKSSADTAKKTLTIYSTMSTDSE RDTFRKLAAAFEKEHSDIHVSLHFPGNDYENMMRVRMAANDLPDLFDTHGWGKIRYGE YTADLRDMKWTQDLDPNLNSILKNKSGKVYAYPINQAKDGLAYNRNILDRYGIAPPET MDDFIKALRTIKEKSKGSIVPFWFAGYDKSSFAQYYDQFATPLLITDPAHNEKKQLIN GTFQWSKFTYLSEILKQMQKEKLINIDAVTAKKSQLIELMAQNKIAFTMQGGTLGQDV AQINPNVKVGIIPTPAIHPGDDPIWIGGERYTLAAWKDSPQLKEAKDFIAFMARPANA KQMAEATSLPSGLTNVKADIFYANDYEYYQDVKVEPYFDRLYLPNGMWDVLGTVGQEL AADILAPQDISQKLGREYKRLREQSETQGAENNE*" gene 2918357..2919637 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" CDS 2919630..2920541 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 12847288, 15849754, 16707683, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="carbohydrate ABC transporter (permease)" /protein_id="NP_390906.1" /db_xref="EnsemblGenomes-Gn:BSU30280" /db_xref="EnsemblGenomes-Tr:CAB15006" /db_xref="GOA:O34706" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12565" /db_xref="UniProtKB/Swiss-Prot:O34706" /translation="MSEIARDVHVKQVKPKKQSSLWWMYIPALLSVLVFMIYPFVKGT LITFTNWNGFSQVYQWVGFAQYERLFSDPDTWHILKNTLHYGLGSTFFQNVVGLLYAL LLNQSIKTKAVTRTIVYLPVMISPLIMGYIWYFFFSYDGGALNDLLGVFGISPINALA SPSLNPWIIVMINTYQYVGIAMVVYLAGLQSIPKDYYEAAQMDGAKQGQQFFTITLPL LMPSITINIVINIIGGLKLFDVIIALTAGGPGNASQSMSTFMYDLYFKRQDAGYAATQ GIFMAFVILIISFCALAYFKRKETEMS*" gene 2919630..2920541 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" CDS 2920538..2921368 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 15849754, 16707683, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="maltose and multiple sugars ABC transporter (permease)" /protein_id="NP_390907.1" /db_xref="EnsemblGenomes-Gn:BSU30290" /db_xref="EnsemblGenomes-Tr:CAB15007" /db_xref="GOA:O34518" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12564" /db_xref="UniProtKB/Swiss-Prot:O34518" /translation="MRAARTKSMRIITLLAAIVACAHFIPFYILLTTSLKAKGDYSSK WIFPADISFHNFSEAWERASLGNSFINTMIITGFSALLLIIFGSLAAYPLARRETKLN KAVFALLISIMIIPPLTSMVPLYRMVVDAGMVNTHAIAIFINTAAYMPLTVFLYSGFI RSTIPKELVEAARIDGAGMLKIFFTIVFPLLKPITATICIISCVFIWNDYQFAIFFLQ DQKVQTLTVAMAGFFGENANNLHLVAAAALMAMLPMVVLFLALQKYFIAGLSSGAVKG *" gene 2920538..2921368 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" promotor_-35 2921341..2921345 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2921361..2921380 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2921369 /Source="Nicolas_upshifts" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 2921388..2922686 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" /EC_number="3.2.1.22" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12847288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-D-galactoside galactohydrolase" /protein_id="NP_390908.1" /db_xref="EnsemblGenomes-Gn:BSU30300" /db_xref="EnsemblGenomes-Tr:CAB15008" /db_xref="GOA:O34645" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12615" /db_xref="UniProtKB/Swiss-Prot:O34645" /translation="MKKITFIGAGSTIFAKNVLGDCLLTEALNGFEFALYDIDPKRLQ ESQLMLENLRDRYNPSVAINSYDDRKLALQNAGYVINAIQVGGYKPSTVIDFEIPKRY GLRQTIADTVGIGGIFRSLRTIPVLFDIAKDMEEMCPDAWFLNYTNPMATLTGAMLRY TNIKTIGLCHSVQVCTKDLFKALGMEHDGIEERIAGINHMAWLLEVKKDGTDLYPEIK RRAKEKQKTKHHDMVRFELMDKFGYYVTESSEHNAEYHPYFIKRNYPELISELQIPLD EYPRRCVKQIENWEKMRDDIVNNKNLTHERSKEYGSRIIEAMETNEPFTFGGNVLNTG LITNLPSKAVVEVTCVADRKKITPCFAGELPEQLAALNRTNINTQLMTIEAAVTRKKE AVYQAAMLDPHTSAELSMKDIISMCDDLFAAHGDWLPEYK*" gene 2921388..2922686 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" downshifts 2922667 /Source="Nicolas_upshifts" /id="D1557" /incds=0 /nref=12 /ntot=55 /MaxReadThrough="3.99614" /MaxDrop="3.96455" /score="26.0469828" /energy="-11.9" /TU="NA" /idTUdmin="U2346" /TUdmin=0 /isTUend="TRUE" CDS complement(2922708..2923019) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" /EC_number="2.8.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390909.2" /db_xref="EnsemblGenomes-Gn:BSU30310" /db_xref="EnsemblGenomes-Tr:CAB15009" /db_xref="GOA:O32072" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG13932" /db_xref="UniProtKB/Swiss-Prot:O32072" /translation="MEIKEISTAALKEKIEADEELYLIDVREDEEVAEGMIPQAVHIR MGDIPEKMETLDKDKEYVFICRSGMRSMNVCKYLDEQGFKTVNVEGGMMAWEGETKPK N*" gene complement(2922708..2923019) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" downshifts complement(2922719) /Source="Nicolas_upshifts" /id="D1558" /incds=0 /nref=84 /ntot=254 /MaxReadThrough="2.71726" /MaxDrop="5.77228" /score="23.1306393" /energy="-11.9" /TU="NA" /idTUdmin="U2349" /TUdmin="-20" /isTUend="TRUE" promotor_-10 complement(2923043..2923062) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2923051) /Source="Nicolas_upshifts" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" promotor_-35 complement(2923077..2923084) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2923085 /Source="Nicolas_upshifts" /id="D1559" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="0.749090000000001" /MaxDrop="4.59307" /score="20.1681452" /energy="-11.2" /TU="NA" /idTUdmin="U2346" /TUdmin=418 /isTUend="FALSE" CDS complement(2923136..2925550) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" /EC_number="6.1.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1317842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="leucyl-tRNA synthetase" /protein_id="NP_390910.1" /db_xref="EnsemblGenomes-Gn:BSU30320" /db_xref="EnsemblGenomes-Tr:CAB15010" /db_xref="GOA:P36430" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002302" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR025709" /db_xref="SubtiList:BG10676" /db_xref="UniProtKB/Swiss-Prot:P36430" /translation="MSFQHKEIEKKWQTYWLENKTFATLDNNEKQKFYALDMFPYPSG AGLHVGHPEGYTATDILSRMKRMQGYDVLHPMGWDAFGLPAEQYALDTGNDPAVFTKQ NIDNFRRQIQALGFSYDWDREINTTDPEYYKWTQWIFLKLYEKGLAYVDEVPVNWCPA LGTVLANEEVIDGKSERGGHPVERRPMKQWMLKITAYADRLLEDLEELDWPESIKDMQ RNWIGRSEGAHVHFAIDGHDDSFTVFTTRPDTLFGATYTVLAPEHALVENITTAEQKE AVEAYIKEIQSKSDLERTDLAKTKTGVFTGAYAINPVNGEKLPIWIADYVLASYGTGA VMAVPGHDERDFEFAKTFGLPVKEVVKGGNVEEAAYTGDGEHVNSDFLNGLHKQEAIE KVIAWLEETKNGEKKVTYRLRDWLFSRQRYWGEPIPVIHWEDGTSTAVPEEELPLILP KTDEIKPSGTGESPLANIKEWVEVTDPETGKKGRRETNTMPQWAGSCWYFLRYIDPHN PDQLASPEKLEKWLPVDMYIGGAEHAVLHLLYARFWHKFLYDIGVVPTKEPFQKLYNQ GMILGENNEKMSKSKGNVVNPDEIVASHGADTLRLYEMFMGPLDASIAWSESGLDGAR RFLDRVWRLFIEDSGELNGKIVEGAGETLERVYHETVMKVTDHYEGLRFNTGISQLMV FINEAYKATELPKEYMEGFVKLLSPVAPHLAEELWEKLGHSGTIAYEAWPVYDETKLV DDEVEIVVQLNGKVKAKLQVPADATKEQLEQLAQADEKVKEQLEGKTIRKIIAVPGKL VNIVAN*" gene complement(2923136..2925550) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" downshifts complement(2923140) /Source="Nicolas_upshifts" /id="D1560" /incds=0 /nref=115 /ntot=224 /MaxReadThrough="3.2803" /MaxDrop="4.46738" /score="33.3300042" /energy="-11.2" /TU="U2350" /idTUdmin="U2350" /TUdmin="-67" /isTUend="FALSE" S_feature complement(2925551..2925646) /Source="Nicolas_S_feature" /locus_tag="new_3105044_3105139_c" /HighExp="G150, G180, G135, LBGexp, HPh, LBGtran, Paraq, Lbexp, H2O2, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.989" /label="S1156" misc_RNA complement(2925660..2925874) /gene="tboL" /locus_tag="BSU_misc_RNA_49" /product="T-box riboswitch specific of leucine tRNA ligase" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201, 27169680; Product type n: RNA" /function="16.3: Control" gene complement(2925660..2925874) /gene="tboL" /locus_tag="BSU_misc_RNA_49" downshifts complement(2925691) /Source="Nicolas_upshifts" /id="D1561" /incds=0 /nref=8 /ntot=38 /MaxReadThrough="6.86098" /MaxDrop="4.90189" /score="40.6873438" /energy="-16.7" /TU="U2350" /idTUdmin="U2352" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2925886..2925905) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2925907) /Source="Nicolas_upshifts" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" promotor_-35 2925911..2925916 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2925920..2925925) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2925932..2925950 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2925945..2926385 /Source="Nicolas_S_feature" /locus_tag="new_3105438_3105878" /HighExp="S4, S5, S3, S8, S7, S6, T5.0H, LoTm, C30, M9-stat" /AntisenseName="ytvB" /AntisenseCor="0.57398798861917499" /AntisenseRegPval="-24.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1157" upshifts 2925945 /Source="Nicolas_upshifts" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" CDS complement(2925977..2926312) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16923906; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein" /protein_id="NP_390911.3" /db_xref="EnsemblGenomes-Gn:BSU30330" /db_xref="EnsemblGenomes-Tr:CAB15011" /db_xref="GOA:O34881" /db_xref="InterPro:IPR025353" /db_xref="SubtiList:BG13929" /db_xref="UniProtKB/Swiss-Prot:O34881" /translation="MKMLHQVLIACVIGGIMGILGHVKKRGRLEKPRMTKRFIYLGFL EDWFIGMTASILLVLSADPDSGIQLVILSIISGYGGEAVLRSFDFVRELNSGGEPAES KRQTKTPPE*" gene complement(2925977..2926312) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" S_feature complement(2926307..2926571) /Source="Nicolas_S_feature" /locus_tag="new_3105800_3106064_c" /HighExp="S6, S8, S7, Etha, S5, M9-stat, B60, BT, B36, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1158" promotor_-10 complement(2926556..2926575) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-10" upshifts complement(2926571) /Source="Nicolas_upshifts" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" promotor_-35 complement(2926590..2926597) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-35" promotor_-35 2926610..2926617 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2926631..2926650 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2926647 /Source="Nicolas_upshifts" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" S_feature 2926649..2926716 /Source="Nicolas_S_feature" /locus_tag="new_3106142_3106209" /HighExp="M40t90, Etha, dia5, HiOs, dia15, H2O2, BC, Diami, M0t90, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1159" CDS 2926717..2927502 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="blue light GTP-binding receptor" /protein_id="NP_390912.1" /db_xref="EnsemblGenomes-Gn:BSU30340" /db_xref="EnsemblGenomes-Tr:CAB15012" /db_xref="GOA:O34627" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036513" /db_xref="PDB:1IUM" /db_xref="PDB:2MWG" /db_xref="PDB:2PR5" /db_xref="PDB:2PR6" /db_xref="PDB:4GCZ" /db_xref="SubtiList:BG13928" /db_xref="UniProtKB/Swiss-Prot:O34627" /translation="MASFQSFGIPGQLEVIKKALDHVRVGVVITDPALEDNPIVYVNQ GFVQMTGYETEEILGKNCRFLQGKHTDPAEVDNIRTALQNKEPVTVQIQNYKKDGTMF WNELNIDPMEIEDKTYFVGIQNDITKQKEYEKLLEDSLTEITALSTPIVPIRNGISAL PLVGNLTEERFNSIVCTLTNILSTSKDDYLIIDLSGLAQVNEQTADQIFKLSHLLKLT GTELIITGIKPELAMKMNKLDANFSSLKTYSNVKDAVKVLPIM*" gene 2926717..2927502 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" S_feature 2927503..2927559 /Source="Nicolas_S_feature" /locus_tag="new_3106996_3107052" /HighExp="Sw, M40t90, BC, Etha, dia5, dia15, H2O2, Mt0, M0t90, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1160" CDS complement(2927739..2928932) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390913.1" /db_xref="EnsemblGenomes-Gn:BSU30350" /db_xref="EnsemblGenomes-Tr:CAB15013" /db_xref="GOA:O34546" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13925" /db_xref="UniProtKB/Swiss-Prot:O34546" /translation="MPRALKILVIGMFINVTGASFLWPLNTIYIHNHLGKSLTVAGLV LMLNSGASVAGNLCGGFLFDKIGGFKSIMLGIAITLASLMGLVFFHDWPAYIVLLTIV GFGSGVVFPASYAMAGSVWPEGGRKAFNAIYVAQNAGVAVGSALGGVVASFSFSYVFL ANAVLYLIFFFIVYFGFRNIQTGDASQTSVLDYDAVNSKAKFAALIILSGGYVLGWLA YSQWSTTIASYTQSIGISLSLYSVLWTVNGILIVLGQPLVSFVVKKWAESLKAQMVIG FIIFIVSFSMLLTAKQFPMFLAAMVILTIGEMLVWPAVPTIANQLAPKGKEGFYQGFV NSAATGGRMIGPLFGGVLVDHYGIRALVLSLLVLLLISIATTLLYDKRIKSAKETNKQ ASISS*" gene complement(2927739..2928932) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" downshifts complement(2927759) /Source="Nicolas_upshifts" /id="D1562" /incds=0 /nref=5 /ntot=47 /MaxReadThrough="2.03991" /MaxDrop="3.41948" /score="-7.70376219" /energy="-9.4" /TU="NA" /idTUdmin="U2354" /TUdmin=0 /isTUend="TRUE" S_feature complement(2928933..2929031) /Source="Nicolas_S_feature" /locus_tag="new_3108426_3108524_c" /HighExp="dia15, LBGstat, H2O2, G180, LPhT, Paraq, Oxctl, G150, G135, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1161" promotor_-10 complement(2929012..2929031) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2929031) /Source="Nicolas_upshifts" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" promotor_-35 complement(2929045..2929052) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2929069..2929072 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2929087..2929106 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2929091 /Source="Nicolas_upshifts" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" CDS 2929121..2929867 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390914.2" /db_xref="EnsemblGenomes-Gn:BSU30360" /db_xref="EnsemblGenomes-Tr:CAB15014" /db_xref="GOA:Q795Q5" /db_xref="InterPro:IPR006876" /db_xref="InterPro:IPR035451" /db_xref="SubtiList:BG13924" /db_xref="UniProtKB/Swiss-Prot:Q795Q5" /translation="MEMVLAFLGFLACLIALGYGLYHLVRYVLKKEKRFSKRLFWPLF IGGLVLLFTGAALAEPDTAAANAEKKYSALNAEYKNLTKEHEELEKEYKSVSSEAKKL KDNKEDQDKLEKLKNENSDLKKTQKSLKAEIKELQENQKQLKEDAKTAKAENETLRQD KTKLENQLKETESQTASSHEDTGSSSNNTSKSDETKTADKAEGCNIKGSRNGIYHTPG STYYDRTTDPAEMFCSVEEAEAAGYRAPKR*" gene 2929121..2929867 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" downshifts 2929762 /Source="Nicolas_upshifts" /id="D1563" /incds=1 /nref=2 /ntot=94 /MaxReadThrough="4.11368" /MaxDrop="3.01036" /score="23.2955589" /energy="-11.6" /TU="U2355" /idTUdmin="U2355" /TUdmin="-99" /isTUend="FALSE" downshifts 2929861 /Source="Nicolas_upshifts" /id="D1564" /incds=0 /nref=31 /ntot=169 /MaxReadThrough="1.73994" /MaxDrop="4.19129" /score="23.2955589" /energy="-11.6" /TU="NA" /idTUdmin="U2355" /TUdmin=0 /isTUend="TRUE" CDS complement(2929904..2931844) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14612242, 15849754, 16850406, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 15849754, 16850406, 17905982, 25118291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease)" /protein_id="NP_390915.1" /db_xref="EnsemblGenomes-Gn:BSU30370" /db_xref="EnsemblGenomes-Tr:CAB15015" /db_xref="GOA:O34741" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG13921" /db_xref="UniProtKB/Swiss-Prot:O34741" /translation="MNINQLILRNLKKNLRNYYLYVFALIFSVALYFAFVTLQYDPAI NEVKASIKGAAAIKTASILLVAVVAIFILYANTIFIKRRSKEIGLFQLIGMTKHKIFR ILSAENVMLYFGSLAIGVAAGFSISKLVLMILFKIVDVKADAKLHFSEQALVQTVIVF CGIYLLIMIMNYTFIKKQSILSLFKVTSSTEDKVKKISFFQMLIGALGIVLILTGYYV SSELFGGKFKTINELFVAMSFILGSVIIGTFLFYKGSVTFISNIIRKSKGGYLNISEV LSLSSIMFRMKSNALLLTIITTVSALAIGLLSLAYISYYSSEKTAEQNVAADFSFMNE KDAKLFENKLRESNISFVKKATPVLQANVDIANIMDGTPKEMQGDPGNMQLAVVSDKD VKGVDVAAGEAVFSGYTDLLQKIMVFKDSGVIKVKSKHETQPLKYKGLREEFLVSYTF TSGGMPAVIVDDSLFKQLDKDKDPRIQLAQSTFIGVNVKHDDQMEKANELFQQVNKKN EHLSRLDTSAAQKSLFGMVMFIVGFLGLTFLITSGCILYFKQMGESEDEKPSYTILRK LGFTQGDLIKGIRIKQMYNFGIPLVVGLFHSYFAVQSGWFLFGSEVWAPMIMVMVLYT ALYSIFGFLSVLYYKKVIKSSL*" gene complement(2929904..2931844) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" downshifts complement(2929915) /Source="Nicolas_upshifts" /id="D1565" /incds=0 /nref=13 /ntot=89 /MaxReadThrough="1.56566" /MaxDrop="4.45006" /score="29.4802229" /energy="-11.6" /TU="NA" /idTUdmin="U2356" /TUdmin=0 /isTUend="TRUE" CDS complement(2931834..2932595) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14612242, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 17905982, 25118291; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacitracin ABC efflux transporter (ATP-binding protein)" /protein_id="NP_390916.1" /db_xref="EnsemblGenomes-Gn:BSU30380" /db_xref="EnsemblGenomes-Tr:CAB15016" /db_xref="GOA:O34697" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13920" /db_xref="UniProtKB/Swiss-Prot:O34697" /translation="MVILEANKIRKSYGNKLNKQEVLKGIDIHIEKGEFVSIMGASGS GKTTLLNVLSSIDQVSHGTIHINGNDMTAMKEKQLAEFRKQHLGFIFQDYNLLDTLTV KENILLPLSITKLSKKEANRKFEEVAKELGIYELRDKYPNEISGGQKQRTSAGRAFIH DPSIIFADEPTGALDSKSASDLLNKLSQLNQKRNATIIMVTHDPVAASYCGRVIFIKD GQMYTQLNKGGQDRQTFFQDIMKTQGVLGGVQHEH*" gene complement(2931834..2932595) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" misc_feature complement(2932619..2932637) /Source="Nicolas_upshift_promotors" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2932638) /Source="Nicolas_upshifts" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" CDS complement(2932697..2933701) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase controlling resistance to antibiotics affecting the envelope [YtsA]" /protein_id="NP_390917.1" /db_xref="EnsemblGenomes-Gn:BSU30390" /db_xref="EnsemblGenomes-Tr:CAB15017" /db_xref="GOA:O35044" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13919" /db_xref="UniProtKB/Swiss-Prot:O35044" /translation="MIKAFLIERRSWIAAFLFQQALMLFIAFVDPSISFGNVLYMVYL CILFFIIFLWFRYRKETAFYKSLKTWENNLDVTAINEPETPFEAMVERSIAGQTEHLK QTAARHRLALENEKDELMAWIHEVKTPLTAMHLIIDRMEEKALKSQLSYEWLRIHLLL DQQLHQKRISFIENDLSVEFIQLQPLIFKEIKDLQSWCIQKGIGFDIQLEAKEVLSDA KWLAFIIRQLLTNAVKYSEASEIEIKSFQKGEQTQLQVKDCGRGIDPKDVPRIFDKGF TSTTDHHDQASTGMGLYLAKKAAAPLLIHIDVESEFGAGTVFTLTFPIRNQFEHVISV *" gene complement(2932697..2933701) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" downshifts complement(2932736) /Source="Nicolas_upshifts" /id="D1566" /incds=0 /nref=25 /ntot=187 /MaxReadThrough="2.40611" /MaxDrop="4.6482" /score="29.3236847" /energy="-13.9" /TU="NA" /idTUdmin="U2357" /TUdmin="-5" /isTUend="TRUE" CDS complement(2933694..2934389) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator controlling resistance to antibiotics affecting the envelope [YtsB]" /protein_id="NP_390918.1" /db_xref="EnsemblGenomes-Gn:BSU30400" /db_xref="EnsemblGenomes-Tr:CAB15018" /db_xref="GOA:O34951" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12340" /db_xref="UniProtKB/Swiss-Prot:O34951" /translation="MFKLLLIEDDESLFHEIKDRLTGWSYDVYGIQDFSQVLQEFAAV NPDCVIIDVQLPKFDGFHWCRLIRSRSNVPILFLSSRDHPADMVMSMQLGADDFIQKP FHFDVLIAKIQAMFRRVHHYNTEPSTIKTWCGAAVDAEQNLVSNDKGSVELTKNEMFI LKQLIEQKNKIVSREELIRSLWNDERFVSDNTLTVNVNRLRKKLDALQLGAYIETKVG QGYIAKEEDKFYD*" gene complement(2933694..2934389) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" promotor_-10 complement(2934413..2934431) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2934425) /Source="Nicolas_upshifts" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" promotor_-35 complement(2934447..2934450) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2934486..2935796) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="metabolite permease involved in resistance to cell wall inhibitors" /protein_id="NP_390919.1" /db_xref="EnsemblGenomes-Gn:BSU30410" /db_xref="EnsemblGenomes-Tr:CAB15019" /db_xref="GOA:O35005" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13916" /db_xref="UniProtKB/Swiss-Prot:O35005" /translation="MRFKDQVHFIRRNMKKNRLRVFMTILATTMACAFLVVLSSVGFG IQKTITDMTMSQQIVTKVSVMGKEGDKPIKKADLEKYDHVRSVVERTQVYEPNKATLG NRTNESSNLIFTNMNDELKANMELEKGRVAKSENEIVVGYDFAKRLLTKKESEEYNKK IEEAKGNPEDIKEPKGYTKDILNKTIELSVSKTDSKTGDVTKTKTYDFKIVGITKKPS QDWMEDSNIFISDQFKKDFSEFLDFKGGNVETNIGVFADKFENVEQLTNDLTDDGYYV TSVTTELEGANTFFMVFKIGLIFVGCIAVIISAIGIFNTMTMAVTERTQEIGIMKAIG ASPSIIRRMFLMESAYIGILGCVIGIIISYGVSYLVNLAVPMILAATSGGDAGDLNYT FSYIPASLVIIAVVICGGVAVISGMNPARKATKTNVLTALRREL*" gene complement(2934486..2935796) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" downshifts complement(2934508) /Source="Nicolas_upshifts" /id="D1567" /incds=0 /nref=9 /ntot=170 /MaxReadThrough="4.26891" /MaxDrop="3.83905" /score="28.2472037" /energy="-13.6" /TU="U2359" /idTUdmin="U2359" /TUdmin="-1755" /isTUend="FALSE" CDS complement(2935786..2936481) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22720735, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22720735, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390920.1" /db_xref="EnsemblGenomes-Gn:BSU30420" /db_xref="EnsemblGenomes-Tr:CAB15020" /db_xref="GOA:O34392" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13915" /db_xref="UniProtKB/Swiss-Prot:O34392" /translation="MIDVQHIDHSFTIGKKGRENEVPVLKDVSLSVAKGEIACIVGRS GSGKSTLLNLISGYISPTKGRIVINGTDVTGFNEKEWAQFRLDHFGFIFQSFQLIPGL TTYENVEMPLALKGIKPSERKQKVQDMLKRVGLENHAAHYPNELSGGQQQRVSIARAL ILNPSIILADEPTGSLDSETEHEVLELIQQLNRERGITFVIITHDDEVASIGHSKFQL HDGVLKGGITVEV*" gene complement(2935786..2936481) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" CDS complement(2936496..2937473) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390921.1" /db_xref="EnsemblGenomes-Gn:BSU30430" /db_xref="EnsemblGenomes-Tr:CAB15021" /db_xref="GOA:O34953" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13914" /db_xref="UniProtKB/Swiss-Prot:O34953" /translation="MPDSGLLYKEWRQNKVALVITILVFILGNPLSILNMYLIYQGCV TGKENWVGPCVFSVDYLNSSFISLFWIWGVVLAVSQLGIERSKSFFDFTLSLPYTRGQ IFHAKFLTGGMVIVVPQLIGYVLSVLLIMLLKPDQAVYFHNYSLGMIIVSMLAYSLVM AGGALTGNSFAQLLVSFTVAISPFLLISLPVINLEILFGGSIDFIHGPVPKWVQYFIP IIYVDSKWAENSPYYLVIPAIMTIIFYIIGYISFVKMSNERNGYFFLWKPLNRPVQII VIIIGIMGFGYFGFTASESFAGYLIGMGTGAVIGFLISYFAIYKKMKLL*" gene complement(2936496..2937473) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" CDS complement(2937503..2938489) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390922.1" /db_xref="EnsemblGenomes-Gn:BSU30440" /db_xref="EnsemblGenomes-Tr:CAB15022" /db_xref="GOA:O34898" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13913" /db_xref="UniProtKB/Swiss-Prot:O34898" /translation="MVDRGLLYREWKQNQVVILLSIAFLVLANPLSIVNTYLSYQGCL DRQDPQYCDFIVNYSISNLIDINWVPGVILAVCFLGMERSKGTMDFILSLPYNRSQIF QTKFWLGGFVIVLSQLIGFLLAWLLILVYNPEHVYFFEHSSIGVIVISFMAFSLVMAA GALTGNAFAQLLTAFSAAILPYLIIALPVGNLEVVFGANIWEIFPSPESYFSLASNLS NLVPISYVVNEWLINSKYLLLIPAVMSMLFYLIGFISFKKLPSERNGHFFLWNRLDRP VQILVMAFGILGFGLFGYYTGHSIIGYILGMIIGAVAGFFVSYFSIYKKTKV*" gene complement(2937503..2938489) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" promotor_-35 2938359..2938368 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2938375 /Source="Nicolas_upshifts" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2938381..2938396 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2938483..2939361) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390923.1" /db_xref="EnsemblGenomes-Gn:BSU30450" /db_xref="EnsemblGenomes-Tr:CAB15023" /db_xref="GOA:O34641" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13912" /db_xref="UniProtKB/Swiss-Prot:O34641" /translation="MIELRQLSKAIDGNQVLKDVSLTIEKGEIFGLLGRNGSGKTTML RLIQQIIFADSGTILFDGVEIKKHPKVKQNIIYMPVQNPFYDKYTYKQLVDILRRIYP KFDVTYANELMNRYEIPETKKYRELSTGLKKQLSLVLSFAARPALILLDEPTDGIDAV TRHDVLQLMVDEVAERDTSILITSHRLEDIERMCNRIGFLEDNSLTNVMDLDELKEEY IKIQMAFDTDVNLAIREQNIPMLDQAGVFYTVLIPKSDEEKKSFLRELKPKVWNELPV NLEEVFIAKFGGKRRW*" gene complement(2938483..2939361) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" CDS complement(2939354..2939746) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986249, 11756427, 17194626, 21856850, 28357385" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 11756427, 17194626, 21856850, 28357385; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family, cell wall antibiotics)" /protein_id="NP_390924.1" /db_xref="EnsemblGenomes-Gn:BSU30460" /db_xref="EnsemblGenomes-Tr:CAB15024" /db_xref="GOA:O34712" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13911" /db_xref="UniProtKB/Swiss-Prot:O34712" /translation="MIQIDPRSSTPIYEQIIQQMKELCLKGIMKPGDKLPSVRELATI IIANPNTVSKAYKELEREGIIETLRGRGTYISENAKTTLVEGKMTMIKEQLKQLIIDA HYAGVELEKLHEWIKEISADVKGGKKND*" gene complement(2939354..2939746) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" S_feature complement(2939747..2939991) /Source="Nicolas_S_feature" /locus_tag="new_3119240_3119484_c" /HighExp="Cold, Salt, SMMPr, MG 15, M9-tran, G180, M9-exp, M/G, MG 25, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.71885600000000005" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1162" CDS complement(2939780..2939917) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28357385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513999.1" /db_xref="EnsemblGenomes-Gn:BSU30466" /db_xref="EnsemblGenomes-Tr:CCQ48604" /db_xref="GOA:L8ECR1" /db_xref="UniProtKB/TrEMBL:L8ECR1" /translation="MKHKKRNKRNVPMLIAASVIACSFFLVLVMIGFEWQKSIIDHFY L*" gene complement(2939780..2939917) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" downshifts 2939915 /Source="Nicolas_upshifts" /id="D1568" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="2.62989" /MaxDrop="3.1332" /score="6.69010243" /energy="-14.4" /TU="NA" /idTUdmin="U2361" /TUdmin="-1254" /isTUend="FALSE" promotor_-10 complement(2939986..2940005) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2939991) /Source="Nicolas_upshifts" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" promotor_-35 complement(2940019..2940026) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2940072..2940344) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390925.1" /db_xref="EnsemblGenomes-Gn:BSU30470" /db_xref="EnsemblGenomes-Tr:CAB15025" /db_xref="InterPro:IPR019668" /db_xref="SubtiList:BG13937" /db_xref="UniProtKB/Swiss-Prot:O32073" /translation="MATRQSVDEHLQQCMQAYDYAEEQLKIASKQEHYNDQEYSDAQM QLEDAVNALNKLWLSSNDQQREQLYRMRLQLQSLQNNMILQHPLDV*" gene complement(2940072..2940344) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" downshifts complement(2940079) /Source="Nicolas_upshifts" /id="D1569" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.96566" /MaxDrop="8.4811" /score="36.3100501" /energy="-14.4" /TU="NA" /idTUdmin="U2360" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2940384..2940395) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2940388..2940396 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2940388) /Source="Nicolas_upshifts" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" upshifts 2940399 /Source="Nicolas_upshifts" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" promotor_-10 2940410..2940428 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2940410..2940416) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2940439..2940444 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2940458..2940477 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2940465 /Source="Nicolas_upshifts" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" CDS 2940506..2941474 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10413665; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_390926.1" /db_xref="EnsemblGenomes-Gn:BSU30480" /db_xref="EnsemblGenomes-Tr:CAB15026" /db_xref="GOA:O35008" /db_xref="InterPro:IPR005911" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032432" /db_xref="SubtiList:BG13908" /db_xref="UniProtKB/Swiss-Prot:O35008" /translation="MMQNNPFPYSNTEKRYHTLNYHLREHFGHKVFKVALDGGFDCPN RDGTVAHGGCTFCSAAGSGDFAGNRTDDLITQFHDIKNRMHEKWKDGKYIAYFQAFTN THAPVEVLREKFESVLALDDVVGISIATRPDCLPDDVVDYLAELNERTYLWVELGLQT VHERTALLINRAHDFNCYVEGVNKLRKHGIRVCSHIINGLPLEDRDMMMETAKAVADL DVQGIKIHLLHLLKGTPMVKQYEKGKLEFLSQDDYVQLVCDQLEIIPPEMIVHRITGD GPIELMIGPMWSVNKWEVLGAINKELENRGSYQGKFFQRLEEESAL*" gene 2940506..2941474 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" CDS 2941471..2942055 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24699744; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methylase" /protein_id="NP_390927.1" /db_xref="EnsemblGenomes-Gn:BSU30490" /db_xref="EnsemblGenomes-Tr:CAB15027" /db_xref="GOA:O34614" /db_xref="InterPro:IPR010719" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13909" /db_xref="UniProtKB/Swiss-Prot:O34614" /translation="MILKKILPYSKELLKMAAGEGDIVVDATMGNGHDTQFLAELVGE NGHVYAFDIQESAVANTKERLGDMYQARTTLFHKSHDKIAESLPPETHGKVAAAVFNL GYLPGGDKSITTNGSSTIKAIEQLLSIMKDEGLIVLVVYHGHPEGKAEKNDVLEFCRD LDQQTARVLTYGFINQQNDPPFIVAIEKKAQISK*" gene 2941471..2942055 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" downshifts 2942019 /Source="Nicolas_upshifts" /id="D1570" /incds=0 /nref=58 /ntot=249 /MaxReadThrough="2.35311" /MaxDrop="4.47418" /score="22.0352465" /energy="-11.9" /TU="NA" /idTUdmin="U2362" /TUdmin="-8" /isTUend="TRUE" CDS complement(2942045..2943148) /gene="tbcS" /locus_tag="BSU_30500" /old_locus_tag="BSU30500" /EC_number="4.2.3.130" /experiment="publication(s) with functional evidences, PMID:21627333, 24806199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21627333, 24806199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetraprenyl-beta-curcumene synthase" /protein_id="NP_390928.1" /db_xref="EnsemblGenomes-Gn:BSU30500" /db_xref="EnsemblGenomes-Tr:CAB15028" /db_xref="GOA:O34707" /db_xref="InterPro:IPR019712" /db_xref="SubtiList:BG13901" /db_xref="UniProtKB/Swiss-Prot:O34707" /translation="MTVPEHPFGLMAKVYRDIFPLVHQELDIWKQKSESIHNSELKAQ ATASIRDKTFHCEGGGILALLSGSQKQKCVEFIIAYQTISDYLDNLCDRSTSLDPQDF RMLHASMQDALTVGAELQNYYQFREEQDDSGYLHELVKTCQRVLGSIEHYDMIKPYLL ELCGYYCDLQVHKHVIEHERVPRLEKWFTQYESELPEMEWYEFSACAGSTLGIFCLVA YSFQPDFTESTAKKIRDSYFPYIQGLHILLDYLIDQEEDLLEGDLNFCSYYQSHEEMM DRLEHFIHKADEHLQGIPHENFHRLINRGLLGVYLSDDKVAGQKEMGRLAKKLIKASG KTSLFFYINGRAYRKFQKMSWMKNSKKKAQIIC*" gene complement(2942045..2943148) /gene="tbcS" /locus_tag="BSU_30500" /old_locus_tag="BSU30500" downshifts complement(2942086) /Source="Nicolas_upshifts" /id="D1571" /incds=0 /nref=35 /ntot=240 /MaxReadThrough="3.47268" /MaxDrop="4.45295" /score="16.7564664" /energy="-10.1" /TU="U2364" /idTUdmin="U2365" /TUdmin="-5" /isTUend="TRUE" CDS complement(2943169..2943948) /gene="ytpA" /locus_tag="BSU_30510" /old_locus_tag="BSU30510" /EC_number="3.1.-.-" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11796336" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11796336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phospholipase component of bacilysocin synthesisor export" /protein_id="NP_390929.1" /db_xref="EnsemblGenomes-Gn:BSU30510" /db_xref="EnsemblGenomes-Tr:CAB15029" /db_xref="GOA:O34705" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13900" /db_xref="UniProtKB/Swiss-Prot:O34705" /translation="MWTWKADRPVAVIVIIHGASEYHGRYKWLIEMWRSSGYHVVMGD LPGQGTTTRARGHIRSFQEYIDEVDAWIDKARTFDLPVFLLGHSMGGLVAIEWVKQQR NPRITGIILSSPCLGLQIKVNKALDLASKGLNVIAPSLKVDSGLSIDMATRNEDVIEA DQNDSLYVRKVSVRWYRELLKTIESAMVPTEAFLKVPLLVMQAGDDKLVDKTMVIKWF NGVASHNKAYREWEGLYHEIFNEPEREDVFKAARAFTDQYI*" gene complement(2943169..2943948) /gene="ytpA" /locus_tag="BSU_30510" /old_locus_tag="BSU30510" promotor_-35 2943591..2943598 /Source="Nicolas_upshift_promotors" /id="U2363" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.632367632367632" /psig="0.962037962037962" /xcortree=2858 /SigmaFactorBS="caagcgctttattcactttaaTTTGCAGTccgagacacggtg aTGATAAAATAATTCCCGTAAtccggggatttctttgctgtttaacccattcaatcgc g" /listShort="ytoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2943613..2943632 /Source="Nicolas_upshift_promotors" /id="U2363" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.632367632367632" /psig="0.962037962037962" /xcortree=2858 /SigmaFactorBS="caagcgctttattcactttaaTTTGCAGTccgagacacggtg aTGATAAAATAATTCCCGTAAtccggggatttctttgctgtttaacccattcaatcgc g" /listShort="ytoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2943630 /Source="Nicolas_upshifts" /id="U2363" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.632367632367632" /psig="0.962037962037962" /xcortree=2858 /SigmaFactorBS="caagcgctttattcactttaaTTTGCAGTccgagacacggtg aTGATAAAATAATTCCCGTAAtccggggatttctttgctgtttaacccattcaatcgc g" /listShort="ytoA" /GFF_Attribute="listLong" S_feature complement(2943949..2944528) /Source="Nicolas_S_feature" /locus_tag="new_3123442_3124021_c" /HighExp="dia15, H2O2, Diami, Salt, dia5, M0t90, Lbstat, Etha, Paraq, Lbtran" /AntisenseName="ytoA" /AntisenseCor="-0.44861767737485803" /AntisenseRegPval="-14" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1163" CDS 2943997..2944512 /gene="ytoA" /locus_tag="BSU_30520" /old_locus_tag="BSU30520" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22868757; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme of the carbonic anhydrase family" /protein_id="NP_390930.1" /db_xref="EnsemblGenomes-Gn:BSU30520" /db_xref="EnsemblGenomes-Tr:CAB15030" /db_xref="GOA:O34696" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="SubtiList:BG13896" /db_xref="UniProtKB/Swiss-Prot:O34696" /translation="MIYPYKEHKPDIHPTAFIADNATITGDVVIGEQSSIWFSVVIRG DVAPTRIGNRVNIQDLSCLHQSPNKTLLIEDDATIGHQVTLHSAVIRKNALIGMGSII LDGAEIGEGAFIGAGSLVPPGKIIPPGHLAFGRPAKVIRPLTEEDRKDMQRIRSEYVE KGQYYKFLQQT*" gene 2943997..2944512 /gene="ytoA" /locus_tag="BSU_30520" /old_locus_tag="BSU30520" promotor_-10 complement(2944519..2944538) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2944528) /Source="Nicolas_upshifts" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" S_feature complement(2944530..2944664) /Source="Nicolas_S_feature" /locus_tag="new_3124023_3124157_c" /HighExp="LoTm, Cold, dia5, dia15, Diami, H2O2, S7, G135, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1164" promotor_-35 complement(2944550..2944557) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2944639..2944658) /Source="Nicolas_upshift_promotors" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2944664) /Source="Nicolas_upshifts" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" CDS complement(2944757..2946148) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_390931.1" /db_xref="EnsemblGenomes-Gn:BSU30530" /db_xref="EnsemblGenomes-Tr:CAB15031" /db_xref="GOA:O34618" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG13891" /db_xref="UniProtKB/Swiss-Prot:O34618" /translation="MQKQKQELHRGLEERHISLMSLGAAIGVGLFLGSASAIQLAGPG ILVAYAASGLVMFFIMRALGEMAIQKPVAGSFSRYARDYLGPLAGYLTGWNYWFLWVV TCMAEITAVGIYMGFWFPDVPNWIWALSALVIMTGVNFLAVKAYGELEFWFALIKIVA ILSMIAVGLLMIIAGVGNGGIATGISNLWNNGGFFPHGLKGVLLSLQMVMFAYLGIEM IGVTAGEVKNPQKSLAKAIDTVFWRILIFYVGALFVIMSIYPWQEIGSQGSPFVLTFQ KVGIPSAAGIINFVVLTAALSSCNSGIFSTGRMLFNLAEQKEAPQAYGQLTKGGIPGK AVLASAGALLVGVLLNYVVPAKVFTWVTSIATFGAIWTWAIILLSQIKYRKSLKPEEK KQLKYKMPLFPFTSYVSLAFLAFVVILMAYSPDTRVAVIIGPIWFLILLAVYYGKGFH KKNAAAASERNIS*" gene complement(2944757..2946148) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" downshifts complement(2944765) /Source="Nicolas_upshifts" /id="D1572" /incds=0 /nref=133 /ntot=225 /MaxReadThrough="3.05784" /MaxDrop="5.43778" /score="3.82664462" /energy="-7.5" /TU="U2368" /idTUdmin="U2368" /TUdmin="-220" /isTUend="FALSE" S_feature complement(2946149..2946283) /Source="Nicolas_S_feature" /locus_tag="new_3125642_3125776_c" /HighExp="Oxctl, Paraq, Heat, Lbexp, G150, S0, dia0, H2O2, G180, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1165" CDS complement(2946284..2948182) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" /EC_number="2.4.-.-" /EC_number="6.3.5.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 21949063, 28317238" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 21949063, 28317238; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-diaminopimelic acid amidotransferase (asparagine synthetase)" /protein_id="NP_390932.1" /db_xref="EnsemblGenomes-Gn:BSU30540" /db_xref="EnsemblGenomes-Tr:CAB15032" /db_xref="GOA:P54420" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11831" /db_xref="UniProtKB/Swiss-Prot:P54420" /translation="MCGFVGVFNKHPLAQTADQEELIKQMNQMIVHRGPDSDGYFHDE HVGFGFRRLSIIDVENGGQPLSYEDETYWIIFNGEIYNYIELREELEAKGYTFNTDSD TEVLLATYRHYKEEAASKLRGMFAFLIWNKNDHVLYGARDPFGIKPLYYTTINDQVYF ASERKSLMVAQNDIEIDKEALQQYMSFQFVPEPSTLDAHVKKVEPGSQFTIRPDGDIT FKTYFKANFKPVQTEEDKLVKEVRDAIYDSVNVHMRSDVPVGSFLSGGIDSSFIVSVA KEFHPSLKTFSVGFEQQGFSEVDVAKETAAALGIENISKVISPEEYMNELPKIVWHFD DPLADPAAIPLYFVAKEAKKHVTVALSGEGADELFGGYNIYREPLSLKPFERIPSGLK KMLLHVAAVMPEGMRGKSLLERGCTPLQDRYIGNAKIFEESVKKQLLKHYNPNLSYRD VTKTYFTESSSYSDINKMQYVDIHTWMRGDILLKADKMTMANSLELRVPFLDKVVFDV ASKIPDELKTKNGTTKYLLRKAAEGIVPEHVLNRKKLGFPVPIRHWLKNEMNEWVRNI IQESQTDAYIHKDYVLQLLEDHCADKADNSRKIWTVLIFMIWHSINIEKRYMPEELSH QPKEVIFV*" gene complement(2946284..2948182) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" promotor_-35 2947340..2947346 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2947361..2947372 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2947373 /Source="Nicolas_upshifts" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2948183..2948306) /Source="Nicolas_S_feature" /locus_tag="new_3127676_3127799_c" /HighExp="Paraq, G135, G180, G150, Oxctl, LBGexp, BMM, dia0, Heat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.632, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1166" CDS complement(2948332..2949534) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" /EC_number="2.5.1.6" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16672621, 18634909" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16672621, 18634909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine synthetase" /protein_id="NP_390933.1" /db_xref="EnsemblGenomes-Gn:BSU30550" /db_xref="EnsemblGenomes-Tr:CAB15033" /db_xref="GOA:P54419" /db_xref="InterPro:IPR002133" /db_xref="InterPro:IPR022628" /db_xref="InterPro:IPR022629" /db_xref="InterPro:IPR022630" /db_xref="InterPro:IPR022631" /db_xref="InterPro:IPR022636" /db_xref="SubtiList:BG11840" /db_xref="UniProtKB/Swiss-Prot:P54419" /translation="MSKNRRLFTSESVTEGHPDKICDQISDSILDEILKKDPNARVAC ETSVTTGLVLVSGEITTSTYVDIPKTVRQTIKEIGYTRAKYGFDAETCAVLTSIDEQS ADIAMGVDQALEAREGTMSDEEIEAIGAGDQGLMFGYACNETKELMPLPISLAHKLAR RLSEVRKEDILPYLRPDGKTQVTVEYDENNKPVRIDAIVISTQHHPEITLEQIQRNIK EHVINPVVPEELIDEETKYFINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGA FSGKDATKVDRSAAYAARYVAKNIVAAELADSCEVQLAYAIGVAQPVSISINTFGSGK ASEEKLIEVVRNNFDLRPAGIIKMLDLRRPIYKQTAAYGHFGRHDVDLPWERTDKAEQ LRKEALGE*" gene complement(2948332..2949534) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" downshifts complement(2948351) /Source="Nicolas_upshifts" /id="D1573" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="7.14538" /MaxDrop="3.78097" /score="-4.044113" /energy="-12.1" /TU="U2367,U2368" /idTUdmin="U2367" /TUdmin="-176" /isTUend="FALSE" promotor_-10 complement(2949577..2949588) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2949583) /Source="Nicolas_upshifts" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" S_feature complement(2949585..2949701) /Source="Nicolas_S_feature" /locus_tag="new_3129078_3129194_c" /HighExp="G180, Paraq, G150, Oxctl, G135, BMM, LBGexp, HPh, MG-0.2, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1167" promotor_-35 complement(2949602..2949608) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(2949702..2949840) /gene="mswG" /locus_tag="BSU_misc_RNA_50" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" gene complement(2949702..2949840) /gene="mswG" /locus_tag="BSU_misc_RNA_50" downshifts 2949800 /Source="Nicolas_upshifts" /id="D1574" /incds=0 /nref=3 /ntot=20 /MaxReadThrough="1.15866" /MaxDrop="4.97875" /score="11.8729615" /energy="-16.6" /TU="NA" /idTUdmin="U2369" /TUdmin="-1841" /isTUend="FALSE" promotor_-10 complement(2949849..2949868) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-10" upshifts complement(2949864) /Source="Nicolas_upshifts" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" promotor_-35 complement(2949885..2949889) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-35" promotor_-35 2949961..2949968 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2949980 /Source="Nicolas_upshifts" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" promotor_-10 2949982..2950001 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2950037..2951620 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" /EC_number="4.1.1.49" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400158, 4146915, 15491857, 15720552, 18586936, 20933603, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoenolpyruvate carboxykinase" /protein_id="NP_390934.2" /db_xref="EnsemblGenomes-Gn:BSU30560" /db_xref="EnsemblGenomes-Tr:CAB15034" /db_xref="GOA:P54418" /db_xref="InterPro:IPR001272" /db_xref="InterPro:IPR008210" /db_xref="InterPro:IPR013035" /db_xref="InterPro:IPR015994" /db_xref="SubtiList:BG11841" /db_xref="UniProtKB/Swiss-Prot:P54418" /translation="MNSVDLTADLQALLTCPNVRHNLSAAQLTEKVLSRNEGILTSTG AVRATTGAYTGRSPKDKFIVEEESTKNKIDWGPVNQPISEEAFERLYTKVVSYLKERD ELFVFEGFAGADEKYRLPITVVNEFAWHNLFARQLFIRPEGNDKKTVEQPFTILSAPH FKADPKTDGTHSETFIIVSFEKRTILIGGTEYAGEMKKSIFSIMNFLLPERDILSMHC SANVGEKGDVALFFGLSGTGKTTLSADADRKLIGDDEHGWSDTGVFNIEGGCYAKCIH LSEEKEPQIFNAIRFGSVLENVVVDEDTREANYDDSFYTENTRAAYPIHMINNIVTPS MAGHPSAIVFLTADAFGVLPPISKLTKEQAMYHFLSGYTSKLAGTERGVTSPETTFST CFGSPFLPLPAHVYAEMLGKKIDEHGADVFLVNTGWTGGGYGTGERMKLSYTRAMVKA AIEGKLEDAEMITDDIFGLHIPAHVPGVPDHILQPENTWTNKEEYKEKAVYLANEFKE NFKKFAHTDAIAQAGGPLV*" gene 2950037..2951620 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" downshifts 2951609 /Source="Nicolas_upshifts" /id="D1575" /incds=0 /nref=106 /ntot=269 /MaxReadThrough="2.55056" /MaxDrop="8.3695" /score="11.8729615" /energy="-16.6" /TU="U2369" /idTUdmin="U2369" /TUdmin="-32" /isTUend="FALSE" CDS complement(2951659..2951901) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390935.1" /db_xref="EnsemblGenomes-Gn:BSU30570" /db_xref="EnsemblGenomes-Tr:CAB15035" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019699" /db_xref="PDB:2NWA" /db_xref="SubtiList:BG13882" /db_xref="UniProtKB/Swiss-Prot:O34365" /translation="MGMPVEFNTLIVTKGKEVRIDENIFTLEKDGYRVYPMEIPMDVR KTKFGEKSGTAEVQKLQWEEGRTIITYKLTSLHSVN*" gene complement(2951659..2951901) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" downshifts complement(2951673) /Source="Nicolas_upshifts" /id="D1576" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="1.2088" /MaxDrop="5.1365" /score="38.3436505" /energy="-16.6" /TU="NA" /idTUdmin="U2371" /TUdmin=0 /isTUend="TRUE" CDS complement(2951953..2952726) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27899916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative esterase" /protein_id="NP_390936.1" /db_xref="EnsemblGenomes-Gn:BSU30580" /db_xref="EnsemblGenomes-Tr:CAB15036" /db_xref="GOA:O34493" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13881" /db_xref="UniProtKB/Swiss-Prot:O34493" /translation="MIVEKRRFPSPSQHVRLYTICYLSNGLRVKGLLAEPAEPGQYDG FLYLRGGIKSVGMVRPGRIIQFASQGFVVFAPFYRGNQGGEGNEDFAGEDREDAFSAF RLLQQHPNVKKDRIHIFGFSRGGIMGMLTAIEMGGQAASFVSWGGVSDMILTYEERQD LRRMMKRVIGGTPKKVPEEYQWRTPFDQVNKIQAPVLLIHGEKDQNVSIQHSYLLEEK LKQLHKPVETWYYSTFTHYFPPKENRRIVRQLTQWMKNR*" gene complement(2951953..2952726) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" S_feature complement(2952727..2952817) /Source="Nicolas_S_feature" /locus_tag="new_3132220_3132310_c" /HighExp="S8, dia15, Diami, Etha, S7, dia5, H2O2, G180, Heat, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1168" promotor_-35 2952793..2952802 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2952806..2952825) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2952814 /Source="Nicolas_upshifts" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" promotor_-10 2952815..2952834 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2952819) /Source="Nicolas_upshifts" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" promotor_-35 complement(2952840..2952847) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2952877..2953881 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component" /protein_id="NP_390937.2" /db_xref="EnsemblGenomes-Gn:BSU30595" /db_xref="EnsemblGenomes-Tr:CAB15037" /db_xref="GOA:C0SP84" /db_xref="SubtiList:BG13873" /db_xref="UniProtKB/Swiss-Prot:C0SP84" /translation="MNRWLRLGFACVGSIFLMFALAACKQEETLTKVKVAEVTHSIFY APLYVAESKGFFKEEGLDVDVNTTWGGDKTMTSLLSNGSDIALVGSETSIYVEAQGAK DPVINFAQLTQTDGTFLVAREDVEHFDWDQLKGKTFLGQRKGGMPQMVGEYVLNKHKI DPHKDIDLIQNIDFANIANAFASGTGEYVQLFEPQASLFEKKGIGHIVASFGEESGEV PYTTFMAKQSYLKKNEDTAVKFTKAIYKAQQWVENHSAKDITDAIKDEFDDTDPDVIE TSIERYKKQHSYSPDPLLNEKEWELLQTIMDKSGELPKHIPYNQLVNKEIAEKVTSEK *" gene 2952877..2953881 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" CDS 2953894..2954676 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component, ATP-binding" /protein_id="NP_390939.1" /db_xref="EnsemblGenomes-Gn:BSU30610" /db_xref="EnsemblGenomes-Tr:CAB15039" /db_xref="GOA:O34314" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13875" /db_xref="UniProtKB/Swiss-Prot:O34314" /translation="MSFLHVDHVTHTYFSIKEKTTAVRDIHFDAEKGDFISFLGPSGC GKTTLLSIIAGLIEPSEGRVLIEGREPNQKEHNIGYMLQQDYLFPWKSIEENVLLGLK IADTLTEESKAAALGLLPEFGLIDVEKKYPKELSGGMRQRAALARTLAPNPSLLLLDE PFSALDFQTKLSLENLVFRTLKEYQKTAVLVTHDIGEAIAMSDTIFLFSNQPGTIHQI FTIPKELAAMLPFDARQEPSFQTLFQTIWKELNSLEKQQRNH*" gene 2953894..2954676 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" S_feature complement(2953898..2955446) /Source="Nicolas_S_feature" /locus_tag="new_3133391_3134939_c" /HighExp="Cold, S8, G180, H2O2, G135, Paraq, G150, S7, Oxctl, LPh" /AntisenseName="ytlC" /AntisenseCor="0.110169300738282" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1169" CDS 2954651..2955463 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease of ABC anion transporter" /protein_id="NP_390940.1" /db_xref="EnsemblGenomes-Gn:BSU30620" /db_xref="EnsemblGenomes-Tr:CAB15040" /db_xref="GOA:O34649" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13876" /db_xref="UniProtKB/Swiss-Prot:O34649" /translation="MRNSKETIDLLHEQYQFKQKKEKWKVHSFQLAIFILFFSGWEIS SRQGWIDPLIFSSPSAVWRLLLEKLGDGSLLSHIGVTLFETVLGFLLGTFMGTCLAAL LWWSNRLARILDPYLVILNAMPKVALGPILIVALGPSFISIIAMGAIISVIITTIVVY TAFQEVDENYTKVMKTFGAKKWVIFKEVILPASSPAIISTLKVNVGLSWVGVIVGEFL VSKVGLGYMIIYGFQVFNFTLVFLSLLIIAIFATLMYQGVELLEKKWTKGRT*" gene 2954651..2955463 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" downshifts 2955448 /Source="Nicolas_upshifts" /id="D1577" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="3.58734" /MaxDrop="4.596" /score="38.1379668" /energy="-12.6" /TU="U2370" /idTUdmin="U2370" /TUdmin="-242" /isTUend="FALSE" CDS complement(2955490..2955966) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" /EC_number="3.6.1.15" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576788, 16513759, 21925382, 23610407, 23610425, 27936487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576788, 16513759, 21925382, 23610407, 23610425, 27936487; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nucleoside and RNA triphosphate phosphohydrolase" /protein_id="NP_390941.1" /db_xref="EnsemblGenomes-Gn:BSU30630" /db_xref="EnsemblGenomes-Tr:CAB15041" /db_xref="GOA:O35013" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR014078" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="PDB:4JZS" /db_xref="PDB:4JZT" /db_xref="PDB:4JZU" /db_xref="PDB:4JZV" /db_xref="SubtiList:BG13869" /db_xref="UniProtKB/Swiss-Prot:O35013" /translation="MYEFKDYYQNTVQLSFDDQPFSDSPKHVWVICRFGGKWLLTEHE DRGYEFPGGKVEPMECAEEAALREVKEETGARVKSLKYLGQYKVLGKEKVIVKNIYFA DIEKLEKQADYFETKGPVLFHELPENLSRNKKFSFIMKDSVLPISLKKLKESGWIE*" gene complement(2955490..2955966) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" downshifts complement(2955491) /Source="Nicolas_upshifts" /id="D1578" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.52721" /MaxDrop="6.99686" /score="36.2618206" /energy="-12.6" /TU="U2372" /idTUdmin="U2373" /TUdmin=11 /isTUend="TRUE" misc_feature complement(2955996..2956015) /Source="Nicolas_upshift_promotors" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2956009) /Source="Nicolas_upshifts" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" S_feature complement(2956011..2956145) /Source="Nicolas_S_feature" /locus_tag="new_3135504_3135638_c" /HighExp="BT, B36, S8, S5, S7, Etha, S6, S4, B60, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK, SigB" /TUshortPSig="0.909, 1, 0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1170" upshifts complement(2956145) /Source="Nicolas_upshifts" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" promotor_-10 complement(2956147..2956158) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2956173..2956179) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2956175..2956579) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative autolytic amidase" /protein_id="NP_390942.1" /db_xref="EnsemblGenomes-Gn:BSU30640" /db_xref="EnsemblGenomes-Tr:CAB15042" /db_xref="GOA:O34883" /db_xref="InterPro:IPR006480" /db_xref="SubtiList:BG13868" /db_xref="UniProtKB/Swiss-Prot:O34883" /translation="MDRDFGIFSFLAVSVSAAGFFFGGFQYSFLILLSLMAIEFISTT LKETIIHKLSFKKVFARLVKKLVTLALISVCHFFDQLLNTQGSIRDLAIMFYILYESV QIVVTASSLGIPVPQMLVDLLETLKNKFKRKP*" gene complement(2956175..2956579) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" promotor_-10 complement(2956607..2956626) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2956624) /Source="Nicolas_upshifts" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" S_feature complement(2956626..2956712) /Source="Nicolas_S_feature" /locus_tag="new_3136119_3136205_c" /HighExp="Etha, B36, S8, B60, S7, LoTm, Salt, Sw, Gly, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1171" promotor_-35 complement(2956639..2956648) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2956745..2957182) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12767829, 16091047, 16861227, 16935006; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-protecting protein, mini-ferritin" /protein_id="NP_390943.1" /db_xref="EnsemblGenomes-Gn:BSU30650" /db_xref="EnsemblGenomes-Tr:CAB15043" /db_xref="GOA:P80879" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="SubtiList:BG12584" /db_xref="UniProtKB/Swiss-Prot:P80879" /translation="MSEQLIQAVNKQVANWTVMYVKLHNYHWYVKGKDFFTLHEKFEE LYNETATYIDDLAERLLALNGKPIATMKESLETASVKEAAGNETAEQMVQSVYDDFTV IAEELKNGMDLADEVGDETTGDMLLAIHQNIEKHNWMLKAYLG*" gene complement(2956745..2957182) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" downshifts complement(2956757) /Source="Nicolas_upshifts" /id="D1579" /incds=0 /nref=188 /ntot=382 /MaxReadThrough="3.87056" /MaxDrop="7.83664" /score="36.0931083" /energy="-19.2" /TU="U2375" /idTUdmin="U2377" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(2957199..2957217) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2957217) /Source="Nicolas_upshifts" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" S_feature complement(2957219..2957444) /Source="Nicolas_S_feature" /locus_tag="new_3136712_3136937_c" /HighExp="M0t90, Lbstat, M40t90, ferm, S2, nit, M40t45, S0, Lbtran, BT" /AntisenseName="ytzI" /AntisenseCor="-0.30531150128448598" /AntisenseRegPval="-6.5" /CDS_PredictionProba="0.38276900000000003" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1172" promotor_-35 complement(2957232..2957238) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2957274..2957293 /Source="Nicolas_upshift_promotors" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 2957275..2957451 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097774.1" /db_xref="EnsemblGenomes-Gn:BSU30659" /db_xref="EnsemblGenomes-Tr:CAX52680" /db_xref="GOA:C0H3Q1" /db_xref="InterPro:IPR022248" /db_xref="UniProtKB/Swiss-Prot:C0H3Q1" /translation="MLQLLKNGRWNVMTLLITISILIVLAVLLVTIWTTVKAYNVKHT IDPPQENHSDSHNQ*" gene 2957275..2957451 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" upshifts 2957276 /Source="Nicolas_upshifts" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" CDS complement(2957445..2957882) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390944.1" /db_xref="EnsemblGenomes-Gn:BSU30660" /db_xref="EnsemblGenomes-Tr:CAB15044" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR032693" /db_xref="SubtiList:BG11027" /db_xref="UniProtKB/Swiss-Prot:P40768" /translation="MKKMLVVLLFSALLLNGCGSGESKANTAETPEVLDVKLTGPEKV NPGESAAYEAAVSYGDEAVTDADEVEFEVWKEGEKDASQMFKVKQEKGVYRLETTFKE DGVYTVQSHVTAKKQHSMPTLKVQVGDADAASNQSEEEHSHHH*" gene complement(2957445..2957882) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" downshifts 2957471 /Source="Nicolas_upshifts" /id="D1580" /incds=0 /nref=37 /ntot=155 /MaxReadThrough="2.0116" /MaxDrop="3.95427" /score="13.1411485" /energy="-20.5" /TU="NA" /idTUdmin="U2376" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(2957901..2957920) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-10" upshifts complement(2957922) /Source="Nicolas_upshifts" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" promotor_-35 complement(2957931..2957939) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-35" CDS complement(2958002..2958475) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" /EC_number="4.4.1.21" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-ribosylhomocysteine lyase" /protein_id="NP_390945.1" /db_xref="EnsemblGenomes-Gn:BSU30670" /db_xref="EnsemblGenomes-Tr:CAB15045" /db_xref="GOA:O34667" /db_xref="InterPro:IPR003815" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR037005" /db_xref="PDB:1IE0" /db_xref="PDB:1J98" /db_xref="PDB:1JQW" /db_xref="PDB:1JVI" /db_xref="PDB:1YCL" /db_xref="PDB:2FQO" /db_xref="PDB:2FQT" /db_xref="SubtiList:BG13866" /db_xref="UniProtKB/Swiss-Prot:O34667" /translation="MPSVESFELDHNAVVAPYVRHCGVHKVGTDGVVNKFDIRFCQPN KQAMKPDTIHTLEHLLAFTIRSHAEKYDHFDIIDISPMGCQTGYYLVVSGEPTSAEIV DLLEDTMKEAVEITEIPAANEKQCGQAKLHDLEGAKRLMRFWLSQDKEELLKVFG*" gene complement(2958002..2958475) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" downshifts complement(2958011) /Source="Nicolas_upshifts" /id="D1581" /incds=0 /nref=72 /ntot=201 /MaxReadThrough="4.53626" /MaxDrop="4.63695" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-793" /isTUend="FALSE" downshifts complement(2958098) /Source="Nicolas_upshifts" /id="D1582" /incds=1 /nref=1 /ntot=96 /MaxReadThrough="5.57623" /MaxDrop="2.4806" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-880" /isTUend="FALSE" S_feature complement(2958476..2958827) /Source="Nicolas_S_feature" /locus_tag="new_3137969_3138320_c" /HighExp="Etha, B36, B60, BMM, S2, Heat, S1, LoTm, Lbtran, S5" /AntisenseName="ytjA" /AntisenseCor="-0.45038987072908898" /AntisenseRegPval="-14.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1173" promotor_-35 2958547..2958554 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2958567..2958586 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2958572 /Source="Nicolas_upshifts" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 2958604..2958831 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19306042, 21803992; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein insertion efficiency factor" /protein_id="NP_390946.1" /db_xref="EnsemblGenomes-Gn:BSU30680" /db_xref="EnsemblGenomes-Tr:CAB15046" /db_xref="GOA:O34601" /db_xref="InterPro:IPR002696" /db_xref="SubtiList:BG13865" /db_xref="UniProtKB/Swiss-Prot:O34601" /translation="MKTLFIALIRGYQKFISPLTPPTCRFYPTCSQYGIEAIKTHGAL KGGWLTIKRILKCHPFHPGGVDPVPEKKQKH*" gene 2958604..2958831 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" CDS complement(2958828..2959391) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" /EC_number="4.2.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12193617, 21266987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carbonic anhydrase" /protein_id="NP_390947.1" /db_xref="EnsemblGenomes-Gn:BSU30690" /db_xref="EnsemblGenomes-Tr:CAB15047" /db_xref="GOA:O34872" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG13863" /db_xref="UniProtKB/Swiss-Prot:O34872" /translation="MSLLNDILEFNKTFTEQREYEKYQTSKFPDKKMAILSCMDTRLV ELLPHAMNLRNGDVKIIKSAGALVTHPFGSIMRSILVAVYELNADEVCVIGHHDCGMS KISSKSMLEKIKARGIPEERIETIKYSGVDFDQWFKSFDSVEASVKDSVDVIKHHPLF PENVPVHGLVIDPKTGKLDLIVNGYNN*" gene complement(2958828..2959391) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" misc_feature complement(2959416..2959435) /Source="Nicolas_upshift_promotors" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2959431) /Source="Nicolas_upshifts" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" CDS complement(2959485..2959733) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15049826, 16014871, 16547061, 19648245, 20208344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15049826, 16014871, 16547061, 19648245, 20208344; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_390948.1" /db_xref="EnsemblGenomes-Gn:BSU30700" /db_xref="EnsemblGenomes-Tr:CAB15048" /db_xref="GOA:O34967" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027493" /db_xref="InterPro:IPR034704" /db_xref="SubtiList:BG13862" /db_xref="UniProtKB/Swiss-Prot:O34967" /translation="MKEGIHPKNHKVIFQDVNSGYRFLSTSTKTSNETAEWEDGNTYP VIKVEVSSDTHPFYTGRQKFNEKGGRVEQFKKRYNMGK*" gene complement(2959485..2959733) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" downshifts complement(2959506) /Source="Nicolas_upshifts" /id="D1583" /incds=0 /nref=96 /ntot=217 /MaxReadThrough="7.96356" /MaxDrop="4.50701" /score="15.8096104" /energy="-7.5" /TU="U2380" /idTUdmin="U2380" /TUdmin="-2288" /isTUend="FALSE" promotor_-10 complement(2959761..2959780) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-10" promotor_-35 complement(2959794..2959801) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-35" upshifts complement(2959798) /Source="Nicolas_upshifts" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" promotor_-35 2959860..2959866 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-35" promotor_-10 2959880..2959891 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-10" upshifts 2959892 /Source="Nicolas_upshifts" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" CDS 2959938..2961269 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9852001, 10551842, 15849754, 16850406, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit I" /protein_id="NP_390949.2" /db_xref="EnsemblGenomes-Gn:BSU30710" /db_xref="EnsemblGenomes-Tr:CAB15049" /db_xref="GOA:C0SP90" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG13857" /db_xref="UniProtKB/Swiss-Prot:C0SP90" /translation="MDDLVLARSLFGTTMGFHIIFATLGVGLPLMILVAELIYQKTKD DHYAIMAKRWTKAQAVLLGVAIPTGTIAGTQLALLWPGFMEVIGRVMSLPFQIEIYAF FVEALFMSIYVYAADRLSPAMRIVAVFFVLVGAAASAVLITNVHAFEGTPAGFKILNG KITDVDPWAAFFNPSFFITAGHVVLSAFMTGAFIVASVAAYKMIRTRKKERVYRFHRK ALLLALTIGGIFSLLTALNGHESAQMLYEYQPEKLAGAEGLFETRSHAPLAIGGFTDP NEEKVKWAIEIPWALSFLAANRFDTVVKGLNAFPRDEWPPLFIHTLFNAMVGVGMLLI LYSIIGVVWRKVLKKDRFPTWLLIIFMTAGPFSLIGIEFGWIFACTGRQPWVIYHLLK TSDVVTTTGSIGVLFLFFTFVYAVLGAAVVYVLLYYFRKHPVDEDLNTAES*" gene 2959938..2961269 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" CDS 2961313..2962353 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11073895, 15576792, 15849754, 16850406, 10551842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit II" /protein_id="NP_390950.1" /db_xref="EnsemblGenomes-Gn:BSU30720" /db_xref="EnsemblGenomes-Tr:CAB15050" /db_xref="GOA:O34505" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG13858" /db_xref="UniProtKB/Swiss-Prot:O34505" /translation="MEISTDALIAISIIWGFVFIYAVMATMDFGAGFWSMIYLNKEHM KATDIANRFLSPTWEVTNVFIVAIVVALFSFFPGATFVLGTVLLIPGSMILLLLAIRS GFLVFSNTAKERKTLRYISGISGFIIPAILILVLPVTHGGFIEKTDGIYNLNMSKIFS SPNAYSFIGFAILSTLFLSSLLLADFSNVAEEQDAYRAYRKSALITGPISLLFAVCIM VTMRNEANWLYSGMMNDFSWIIASFITFVIAGIALFLPNKSFGQNIGKPRLALVAIGI QYFLASYAYGRAHLPYMIYPDVTVMSGFTEPATFRALFATYIVAFIILFPGFFFFWKM FMRDKRYIRQEE*" gene 2961313..2962353 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" promotor_-35 2962347..2962353 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2962368..2962379 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2962378 /Source="Nicolas_upshifts" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" CDS 2962407..2962565 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097775.1" /db_xref="EnsemblGenomes-Gn:BSU30739" /db_xref="EnsemblGenomes-Tr:CAX52681" /db_xref="InterPro:IPR011437" /db_xref="UniProtKB/Swiss-Prot:C0H3Q2" /translation="MEQKILCEVNNCSYWGKGNKCTADAIYVVSHTGETAENSRETDC KTFKPHDL*" gene 2962407..2962565 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" downshifts 2962554 /Source="Nicolas_upshifts" /id="D1584" /incds=0 /nref=55 /ntot=88 /MaxReadThrough="1.7679" /MaxDrop="7.01398" /score="-5.86934022" /energy="-7" /TU="NA" /idTUdmin="U2382" /TUdmin=0 /isTUend="TRUE" CDS complement(2962584..2963471) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390952.1" /db_xref="EnsemblGenomes-Gn:BSU30740" /db_xref="EnsemblGenomes-Tr:CAB15052" /db_xref="GOA:O34500" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG13854" /db_xref="UniProtKB/Swiss-Prot:O34500" /translation="MSFEAWIIATGVLVGVSCGLIGTFLVLRSMAMLADAISHTVLLG IVGAFLVTGSLDGIYMFIGAAATGLLTAFLVQLLHSKGVQSDAAIGVVFTSLFAIGVI LLSVYGANVHLDIEHSLMGEIAFVPWNTVTVFGVDIGPKAFWMLASVLVLNVVLISVC YKEFKIASFDPQMALALGIPVLLIHYVQMGMLSLTTVASFDSVGAVLVVAMLIVPPAA AHLLTDRLLYMLILSALIGGLSAVMGYFFATWLNVSISGAMAAMTGVCYASAFLFSPA NGVITKKLRTLNMQKERAG*" gene complement(2962584..2963471) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" downshifts complement(2962607) /Source="Nicolas_upshifts" /id="D1585" /incds=0 /nref=121 /ntot=218 /MaxReadThrough="3.39755" /MaxDrop="6.80546" /score="-8.37820006" /energy="-7" /TU="U2385" /idTUdmin="U2385" /TUdmin="-637" /isTUend="FALSE" CDS complement(2963461..2964768) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390953.1" /db_xref="EnsemblGenomes-Gn:BSU30750" /db_xref="EnsemblGenomes-Tr:CAB15053" /db_xref="GOA:O35024" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13853" /db_xref="UniProtKB/Swiss-Prot:O35024" /translation="MFESLWLQLQHPNTQWVLAGTLLLGTASGVLGSFVLLRKQSLIG DAMAHSALPGVCLAFLFTGQKSLPFFLLGAALAGLLGTFCIQLIPRLSKTKEDSAIGI VLSVFFGVGIILLTYIQQQGAGSQSGLDSFLFGQAASLVRQDIILIAGISAVLLLLCI VFFKEFTLITFDLAFAKGLGIPVRFLNGLLACLIVCAVVIGLQTVGVILMAAMLITPA ITARYWTERLTGMIIIAGITGGVSGVAGTLLSTTMKGMATGPLMILSATLLFLFSMIC APKRGLAAKAIRLMRLRRRTSREQVLLAIYEQYEKNNLCVTVESVRKKRRLSPSLCLK ALNDLEQERCIERIENGIWQITSKGIEKGYHTALKQRMYEVYLMHEMELANIESDQDY FDPDRLPRETRERLYSLLKLYGRMPERRKASHDAEKGQIANEF*" gene complement(2963461..2964768) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" CDS complement(2964774..2965526) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type t: transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (ATP-binding protein)" /protein_id="NP_390954.1" /db_xref="EnsemblGenomes-Gn:BSU30760" /db_xref="EnsemblGenomes-Tr:CAB15054" /db_xref="GOA:O34338" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13852" /db_xref="UniProtKB/Swiss-Prot:O34338" /translation="MFPVELDNVTVAYHKKPVLQDISLQVPEGKLIGIIGPNGAGKST LIKTILGLVPRASGDISIYGKDYKDQRTRIGYVPQRGSVDWDFPTSPLDVVLMGRYGR IGLLKRPKKADVEMAKAALTKVGMHDYAKRQISQLSGGQQQRVFLARALCQNADIYFM DEPFAGVDAATERAIMTLLAELKEKGKTVLVVHHDLQTAEDYFDWILLLHLRKIAFGP TENVFTIENLQKTYGGRLTFLKDKVLAEGHKE*" gene complement(2964774..2965526) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" CDS complement(2965545..2966465) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (manganese binding lipoprotein)" /protein_id="NP_390955.1" /db_xref="EnsemblGenomes-Gn:BSU30770" /db_xref="EnsemblGenomes-Tr:CAB15055" /db_xref="GOA:O34385" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="SubtiList:BG13851" /db_xref="UniProtKB/Swiss-Prot:O34385" /translation="MRQGLMAAVLFATFALTGCGTDSAGKSADQQLQVTATTSQIADA AENIGGKHVKVTSLMGPGVDPHLYKASQGDTKKLMSADVVLYSGLHLEGKMEDVLQKI GEQKQSAAVAEAIPKNKLIPAGEGKTFDPHVWFSIPLWIYAVDEIEAQFSKAMPQHAD AFRKNAKEYKEDLQYLDKWSRKEIAHIPEKSRVLVTAHDAFAYFGNEYGFKVKGLQGL STDSDYGLRDVQELVDLLTEKQIKAVFVESSVSEKSINAVVEGAKEKGHTVTIGGQLY SDAMGEKGTKEGTYEGMFRHNINTITKALK*" gene complement(2965545..2966465) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" promotor_-10 complement(2966501..2966512) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2966502) /Source="Nicolas_upshifts" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2966504..2966595) /Source="Nicolas_S_feature" /locus_tag="new_3145997_3146088_c" /HighExp="T-0.40H, Sw, T-1.40H, BC, C90, C30, BI, T0.0H, T-3.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.985, 0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1174" promotor_-35 complement(2966526..2966532) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2966580 /Source="Nicolas_upshifts" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2966581..2966600) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2966583..2966595 /Source="Nicolas_upshift_promotors" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2966595) /Source="Nicolas_upshifts" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" S_feature complement(2966597..2966678) /Source="Nicolas_S_feature" /locus_tag="new_3146090_3146171_c" /HighExp="T1.30H, T1.0H, C30, T0.30H, T2.0H, T2.30H, T-0.40H, T-1.40H, T-2.40H, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1175" promotor_-35 complement(2966615..2966622) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2966678) /Source="Nicolas_upshifts" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" promotor_-10 complement(2966687..2966706) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-10" promotor_-35 complement(2966720..2966727) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-35" CDS complement(2966745..2967860) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" /EC_number="4.2.1.113" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoate-CoA synthase" /protein_id="NP_390956.1" /db_xref="EnsemblGenomes-Gn:BSU30780" /db_xref="EnsemblGenomes-Tr:CAB15056" /db_xref="GOA:O34514" /db_xref="InterPro:IPR010197" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG13847" /db_xref="UniProtKB/Swiss-Prot:O34514" /translation="MIEIEKITLYHLSMNLKKPFKNSIETLQERKFLIVEAIDTSGVT GWGEVSAFSSPWYTEETIGTCLHMLKDFFIPNVVGREFNHPSEVPDSLARYKGNRMAK AGLESAVWDIYAKKKGVSLAEALGGTRDKVPAGVVVGLAPLDDMLKEIESYQKEGYQR IKIKIQPGQDVELVKAIRSRFPTIPLMADANSSYELKDISRLKELDDYHLMMIEQPLQ ADDIVDHRHLQKHLKTAICLDESICSVDDARRAIELGSCKIINIKPSRVGGLTEALKI HDLCKEHHMQVWCGGMLETGISRAQNVALASLPQFTIPGDISSSSRYWDEDIVTPDIR IDNGFISVSKQPGLGVEVNQDIMRKYVTKMDVFTQHG*" gene complement(2966745..2967860) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" downshifts complement(2966788) /Source="Nicolas_upshifts" /id="D1586" /incds=0 /nref=12 /ntot=179 /MaxReadThrough="3.8638" /MaxDrop="2.96378" /score="29.7201414" /energy="-11.1" /TU="U2387,U2388" /idTUdmin="U2388" /TUdmin="-22" /isTUend="TRUE" CDS complement(2967857..2969317) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" /EC_number="6.2.1.26" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299, 28559280" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299, 28559280; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoic acid-CoA ligase" /protein_id="NP_390957.1" /db_xref="EnsemblGenomes-Gn:BSU30790" /db_xref="EnsemblGenomes-Tr:CAB15057" /db_xref="GOA:P23971" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010192" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:5BUQ" /db_xref="PDB:5BUR" /db_xref="PDB:5BUS" /db_xref="PDB:5GTD" /db_xref="PDB:5X8F" /db_xref="PDB:5X8G" /db_xref="SubtiList:BG10687" /db_xref="UniProtKB/Swiss-Prot:P23971" /translation="MLTEQPNWLMQRAQLTPERIALIYEDQTVTFAELFAASKRMAEQ LAAHSVRKGDTAAILLQNRAEMVYAVHACFLLGVKAVLLNTKLSTHERLFQLEDSGSG FLLTDSSFEKKEYEHIVQTIDVDELMKEAAEEIEIEAYMQMDATATLMYTSGTTGKPK GVQQTFGNHYFSAVSSALNLGITEQDRWLIALPLFHISGLSALFKSVIYGMTVVLHQR FSVSDVLHSINRHEVTMISAVQTMLASLLEETNRCPESIRCILLGGGPAPLPLLEECR EKGFPVFQSYGMTETCSQIVTLSPEFSMEKLGSAGKPLFSCEIKIERDGQVCEPYEHG EIMVKGPNVMKSYFNRESANEASFQNGWLKTGDLGYLDNEGFLYVLDRRSDLIISGGE NIYPAEVESVLLSHPAVAEAGVSGAEDKKWGKVPHAYLVLHKPVSAGELTDYCKERLA KYKIPAKFFVLDRLPRNASNKLLRNQLKDARKGELL*" gene complement(2967857..2969317) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" promotor_-10 complement(2968760..2968778) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2968764) /Source="Nicolas_upshifts" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" promotor_-35 complement(2968793..2968799) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2969406) /Source="Nicolas_upshifts" /id="D1587" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="4.92536" /MaxDrop="2.4145" /score="1.01127104" /energy="-10.8" /TU="U2388" /idTUdmin="U2389" /TUdmin=682 /isTUend="FALSE" CDS complement(2969408..2970223) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" /EC_number="4.1.3.36" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxynapthoic acid synthetase" /protein_id="NP_390958.1" /db_xref="EnsemblGenomes-Gn:BSU30800" /db_xref="EnsemblGenomes-Tr:CAB15058" /db_xref="GOA:P23966" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR010198" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG10686" /db_xref="UniProtKB/Swiss-Prot:P23966" /translation="MAEWKTKRTYDEILYETYNGIAKITINRPEVHNAFTPKTVAEMI DAFADARDDQNVGVIVLAGAGDKAFCSGGDQKVRGHGGYVGDDQIPRLNVLDLQRLIR VIPKPVVAMVSGYAIGGGHVLHIVCDLTIAADNAIFGQTGPKVGSFDAGYGSGYLARI VGHKKAREIWYLCRQYNAQEALDMGLVNTVVPLEQLEEETIKWCEEMLEKSPTALRFL KAAFNADTDGLAGIQQFAGDATLLYYTTDEAKEGRDSFKEKRKPDFGQFPRFP*" gene complement(2969408..2970223) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" CDS complement(2970258..2971082) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" /EC_number="4.2.99.20" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12454479, 23637813; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase" /protein_id="NP_390959.1" /db_xref="EnsemblGenomes-Gn:BSU30810" /db_xref="EnsemblGenomes-Tr:CAB15059" /db_xref="GOA:P23974" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR022485" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10685" /db_xref="UniProtKB/Swiss-Prot:P23974" /translation="MGTVNITVSDGVRYAVADEGPNASEAVVCLHGFTGSKQSWTFLD EMLPDSRLIKIDCLGHGETDAPLNGKRYSTTRQVSDLAEIFDQLKLHKVKLIGYSMGG RLAYSFAMTYPERVSALVLESTTPGLKTLGERRERIMRDRKLADFILRDGLEAFVAYW ENIPLFSSQQRLAEDIRYRIRSGRLRNNKIGLANSLTGMGTGSQPSLWSRVEEIDVPV LLICGEWDEKFCAINQEVHKMLPSSRIEIVPKAGHTVHVEQPRLFGKIVSEFLTSI*" gene complement(2970258..2971082) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" promotor_-10 complement(2970340..2970359) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2970340) /Source="Nicolas_upshifts" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" promotor_-35 complement(2970375..2970378) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2970506) /Source="Nicolas_upshifts" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" promotor_-10 complement(2970516..2970527) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2970542..2970548) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2971070..2972812) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" /EC_number="2.2.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate decarboxylase and 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase" /protein_id="NP_390960.1" /db_xref="EnsemblGenomes-Gn:BSU30820" /db_xref="EnsemblGenomes-Tr:CAB15060" /db_xref="GOA:P23970" /db_xref="InterPro:IPR004433" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR032264" /db_xref="PDB:2X7J" /db_xref="SubtiList:BG10683" /db_xref="UniProtKB/Swiss-Prot:P23970" /translation="MTVNPITHYIGSFIDEFALSGITDAVVCPGSRSTPLAVLCAAHP DISVHVQIDERSAGFFALGLAKAKQRPVLLICTSGTAAANFYPAVVEAHYSRVPIIVL TADRPHELREVGAPQAINQHFLFGNFVKFFTDSALPEESPQMLRYIRTLASRAAGEAQ KRPMGPVHVNVPLREPLMPDLSDEPFGRMRTGRHVSVKTGTQSVDRESLSDVAEMLAE AEKGMIVCGELHSDADKENIIALSKALQYPILADPLSNLRNGVHDKSTVIDAYDSFLK DDELKRKLRPDVVIRFGPMPVSKPVFLWLKDDPTIQQIVIDEDGGWRDPTQASAHMIH CNASVFAEEIMAGLTAATRSSEWLEKWQFVNGRFREHLQTISSEDVSFEGNLYRILQH LVPENSSLFVGNSMPIRDVDTFFEKQDRPFRIYSNRGANGIDGVVSSAMGVCEGTKAP VTLVIGDLSFYHDLNGLLAAKKLGIPLTVILVNNDGGGIFSFLPQASEKTHFEDLFGT PTGLDFKHAAALYGGTYSCPASWDEFKTAYAPQADKPGLHLIEIKTDRQSRVQLHRDM LNEAVREVKKQWEL*" gene complement(2971070..2972812) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" CDS complement(2972809..2974224) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" /EC_number="5.4.4.2" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinone-specific isochorismate synthase" /protein_id="NP_390961.1" /db_xref="EnsemblGenomes-Gn:BSU30830" /db_xref="EnsemblGenomes-Tr:CAB15061" /db_xref="GOA:P23973" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR034681" /db_xref="SubtiList:BG10682" /db_xref="UniProtKB/Swiss-Prot:P23973" /translation="MVTTVQRTFRKEVLHALHKAKEVNHAVLISYSRQIESLDPLSFF NYGAKKYTGNRFFWSDPESELTIVGLGKEAVFQTNQKNSERYREVFEQWERFKKTAFH IYEEEKLQHSAVGPVLFGGFSFDPCEERGSQWDHFSEGDFFVPALMLTMTAEGPFLTV NRWVSGGEDAEAVLEGLKAFAAEFMVPDFKQEDQAVIAAAEELDKDDWLKAIETATSQ IKEKQYDKVVLARELLLTFDGPIQIEPVLKTLLDDQQTSYVFAIEQEGKTFVGASPER LIKRDGGTVMSSCLAGSIKRGVNEEDDRRIGLELLNDEKNLLEHDIVVGMIHNAFVSS CSEVEKPDGPVLYKTKSVQHLFTPIVGQLRESASIFDLIEKLHPTPALGGSPQEKAVD VIREIEPMSRGWYAAPIGWIDSQDNGEFAVAIRSGLIEGSTARLFAGCGIVEDSEPIS EYEETQIKLKPMISALGGERR*" gene complement(2972809..2974224) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" S_feature complement(2974225..2974337) /Source="Nicolas_S_feature" /locus_tag="new_3153718_3153830_c" /HighExp="dia5, LBGstat, Diami, LBGtran, dia15, H2O2, G180, G150, LPhT, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1176" promotor_-10 complement(2974317..2974336) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-10" upshifts complement(2974337) /Source="Nicolas_upshifts" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" S_feature complement(2974339..2974489) /Source="Nicolas_S_feature" /locus_tag="new_3153832_3153982_c" /HighExp="S8, S7, S6, S5, BT, S4, Pyr, B36, G/S, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1177" promotor_-35 complement(2974352..2974355) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-35" promotor_-35 2974450..2974456 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2974470..2974489) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2974470..2974481 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2974478 /Source="Nicolas_upshifts" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" upshifts complement(2974489) /Source="Nicolas_upshifts" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" promotor_-35 complement(2974503..2974512) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2974514..2975233 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative regulatory protein" /protein_id="NP_390962.2" /db_xref="EnsemblGenomes-Gn:BSU30840" /db_xref="EnsemblGenomes-Tr:CAB15062" /db_xref="GOA:P42408" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR014240" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG11200" /db_xref="UniProtKB/Swiss-Prot:P42408" /translation="MLTKEQLQHLKNELEQTKKDILNRFKDNDHFQLNSAFPYDSWGE LSAYDNHPGDQATELYEREKDIALDLHEREHLRDIEHSLKAIENGTYGICEVSGKEIP FERLEALPTATTLAEYSSQDVVSKDRPIEEETPFGQFEFDDDEEIRAPYDSEDSYQDV EKYGNSQTPQDMENPPLSYDDMTMNAEENIGNTESYENFIATDITGKEITVYQSRAHE RYEEELDEEGIMTTFGDLHAD*" gene 2974514..2975233 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" S_feature complement(2974584..2975241) /Source="Nicolas_S_feature" /locus_tag="new_3154077_3154734_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, S3" /AntisenseName="yteA" /AntisenseCor="0.85796245341056299" /AntisenseRegPval="-78.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1178" downshifts 2975222 /Source="Nicolas_upshifts" /id="D1588" /incds=0 /nref=23 /ntot=40 /MaxReadThrough="0.72949" /MaxDrop="5.85132" /score="2.75726503" /energy="-10.1" /TU="NA" /idTUdmin="U2391" /TUdmin="-5" /isTUend="TRUE" CDS complement(2975242..2976060) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_390963.1" /db_xref="EnsemblGenomes-Gn:BSU30850" /db_xref="EnsemblGenomes-Tr:CAB15063" /db_xref="GOA:P42407" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11199" /db_xref="UniProtKB/Swiss-Prot:P42407" /translation="MIKKAIIPAGGFGTRNLPVTKVIPKEMFPVGSKPVIHYLVEELK ESGIEDILMVVSSHKNLIVDYFDSSLALEAFLASKNKLHLLREHPIPDIRIHYVRQPY AKGLGDAISFGKQFAGGEPFAVVLPDDLIFSANQPALGQLIEAYTKYQSSVIGLKETK TEDLHHYGVIKGEPVEKGLYRIQDIVEKPKQNPPSHFAAAGRYIFTPDIFNELEALEA DSGGEVQVTDAIKASLGACTVYGKLLEGERYDIGLQKDYLKLIYDMLKTEKNPQ*" gene complement(2975242..2976060) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" promotor_-10 complement(2976081..2976100) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2976095) /Source="Nicolas_upshifts" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" promotor_-35 complement(2976115..2976123) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2976161..2976169 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2976182..2976201 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2976183 /Source="Nicolas_upshifts" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" CDS 2976232..2977518 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" /EC_number="1.1.1.22" /function="16.14: Store" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose dehydrogenase" /protein_id="NP_390964.1" /db_xref="EnsemblGenomes-Gn:BSU30860" /db_xref="EnsemblGenomes-Tr:CAB15064" /db_xref="GOA:O34862" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13828" /db_xref="UniProtKB/Swiss-Prot:O34862" /translation="MKICVVGAGYVGLTLSAALASIGHDMICTDKDVKKIGQLKKGVI PFYEPGLSDAILRCGNLSFSSEVKSSMEECPVIFIAVGTPPRSDGSADTKALQSVIGD LSEAIRSYKTIITKSTVPPGTNENIAKQLIASGVSKNLFNIVSNPEFLREGNALYDML HPDKTVIGVQEEDHVSAAIVKSIYKHIDTPFIVTSLAGAELIKYANNFFLAAKISFIN EMARICEAYQSDISDISRAIGLDPRIGKHFLQAGIGYGGSCFPKDLQALQFAAQEKNT ETFLLRAVQHINDTQLGLYIKKIQSFFETLQGKKAAVLGISFKPNTDDIRNSQAVRLM ERLAELGCDVHAYDPEAVLPEHLRQHVTQHSQAFDAIEESDFLFLATEWSEFLAFDWK KAADIMKGRLVIDGRNVLKKELIEACGLICTGVGRP*" gene 2976232..2977518 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" CDS 2977515..2978465 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose epimerase" /protein_id="NP_390965.1" /db_xref="EnsemblGenomes-Gn:BSU30870" /db_xref="EnsemblGenomes-Tr:CAB15065" /db_xref="GOA:O34886" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13829" /db_xref="UniProtKB/Swiss-Prot:O34886" /translation="MKILVTGAAGFIGSHLCEELLKDKKHNVIGIDDFIGPTPFSLKL KNLKNLLPEKRFTFIKENLLTADLASLLEGVDVIFHLAAIPGVRSSWGNHFHPYAAHN IQALQRLLEACREHSIQTFVFASTSSVYGEKQGKVSENTSLSPLSPYGVTKLTGEKLC HVYKQSFGIPIVILRFFTVYGPRQRPDMAFHRLIKQHLQQKPLTIFGDGQQSRDFTYI SDCVKGITAVLGKPHLIGETVNIGGAERASVLKVVSLIEDISGRKATLHFSDKIAGEP SNTWADISKAKQLLHYDPATSLKDGLTNEIAYLSSLYQGE*" gene 2977515..2978465 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" CDS 2978468..2979691 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" /EC_number="2.4.1.-" /function="16.14: Store" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glucosyltransferase" /protein_id="NP_390966.1" /db_xref="EnsemblGenomes-Gn:BSU30880" /db_xref="EnsemblGenomes-Tr:CAB15066" /db_xref="GOA:O34413" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG13830" /db_xref="UniProtKB/Swiss-Prot:O34413" /translation="MKLAFICTEKLPAPAVRGGAIQMMIDGVTPYFSSRYDLTIFSIE DPSLPKRETKDGVHYIHLPKEHYREAVAEELRASSFDLIHVFNRPLNVSLYKKASPNS KIVLSLHNEMFSEKKMTFAQGKEVLDNVSMITTVSEFIKQTVIERFPEAEDITKVVYS GVDLNSYPPVWTMKGSAVRKTYRKKYGIEDKKVILFAGRLSPTKGPHLLIHSMRRILQ QHPDAVLVIAGGKWFSDDSENQYVTYLRTLALPYRDHIIFTKFIPADDIPNLFLMADV FVCSSQWNEPLARVNYEAMAAGTPLITTNRGGNGEVVKHEVTGLVIDSYNKPSSFAKA IDRAFTDQELMNKMTKNARKHVEALFTFTHAAKRLNTVYQSVLTPKNKQFPPPFLTQN FDLSSINQLFVKAKT*" gene 2978468..2979691 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" downshifts complement(2979615) /Source="Nicolas_upshifts" /id="D1589" /incds=1 /nref=1 /ntot=10 /MaxReadThrough="1.32025" /MaxDrop="3.47267" /score="-3.65321449" /energy="-3.1" /TU="NA" /idTUdmin="U2395" /TUdmin=66 /isTUend="FALSE" S_feature 2979692..2980259 /Source="Nicolas_S_feature" /locus_tag="new_3159185_3159752" /HighExp="S8, S7, BT, S6, C30, Pyr, S5, G/S, C90, Glucon" /AntisenseName="ytxO" /AntisenseCor="0.86121563743373297" /AntisenseRegPval="-79.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1179" CDS complement(2979765..2980196) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type s: structure" /codon_start=1 /transl_table=11 /product="outer spore coat protein" /protein_id="NP_390967.1" /db_xref="EnsemblGenomes-Gn:BSU30890" /db_xref="EnsemblGenomes-Tr:CAB15067" /db_xref="SubtiList:BG11382" /db_xref="UniProtKB/Swiss-Prot:P46916" /translation="MRSSRQKASISKLDLDQFVFTPPGPMGWQAHDSISAEKEEEEKH LDVGSIRELPHINAPKEYQKETKEKETDRKIVDDEEETKFETTLEPEEERDSKRSAPP YEEEDEDEEPDLAEEAKVEIIILPSESKPAPWFSQTVKRKA*" gene complement(2979765..2980196) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" downshifts complement(2979791) /Source="Nicolas_upshifts" /id="D1590" /incds=0 /nref=11 /ntot=36 /MaxReadThrough="3.07378" /MaxDrop="4.8822" /score="9.30990044" /energy="-8.3" /TU="U2395" /idTUdmin="U2395" /TUdmin="-110" /isTUend="FALSE" CDS complement(2980198..2981253) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7545510, 9603889, 10234840, 11737650, 14702409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7545510, 9603889, 10234840, 11737650, 14702409; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390968.1" /db_xref="EnsemblGenomes-Gn:BSU30900" /db_xref="EnsemblGenomes-Tr:CAB15068" /db_xref="GOA:P46914" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="SubtiList:BG11380" /db_xref="UniProtKB/Swiss-Prot:P46914" /translation="MYQKEHEEQIVSEILSYYPFHIDHVALKSNKSGRKIWEVETDHG PKLLKEAQMKPERMLFITQAHAHLQEKGLPIAPIHQTKNGGSCLGTDQVSYSLYDKVT GKEMIYYDAEQMKKVMSFAGHFHHASKGYVCTDESKKRSRLGKWHKLYRWKLQELEGN MQIAASYPDDVFSQTFLKHADKMLARGKEALRALDDSEYETWTKETLEHGGFCFQDFT LARLTEIEGEPFLKELHSITYDLPSRDLRILLNKVMVKLSVWDTDFMVALLAAYDAVY PLTEKQYEVLWIDLAFPHLFCAIGHKYYLKQKKTWSDEKYNWALQNMISVEESKDSFL DKLPELYKKIKAYREAN*" gene complement(2980198..2981253) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" CDS complement(2981268..2982401) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9603889, 10234840, 11737650" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9603889, 10234840, 11737650; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390969.1" /db_xref="EnsemblGenomes-Gn:BSU30910" /db_xref="EnsemblGenomes-Tr:CAB15069" /db_xref="GOA:P46915" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11381" /db_xref="UniProtKB/Swiss-Prot:P46915" /translation="MKIALIATEKLPVPSVRGGAIQIYLEAVAPLIAKKHEVTVFSIK DPNLADREKVDGVHYVHLDEDRYEEAVGAELKKSRFDLVHVCNRPSWVPKLKKQAPDA VFILSVHNEMFAYDKISQAEGEICIDSVAQIVTVSDYIGQTITSRFPSARSKTKTVYS GVDLKTYHPRWTNEGQRAREEMRSELGLHGKKIVLFVGRLSKVKGPHILLQALPDIIE EHPDVMMVFIGSKWFGDNELNNYVKHLHTLGAMQKDHVTFIQFVKPKDIPRLYTMSDV FVCSSQWQEPLARVHYEAMAAGLPIITSNRGGNPEVIEEGKNGYIIHDFENPKQYAER INDLLSSSEKRERLGKYSRREAESNFGWQRVAENLLSVYEKNR*" gene complement(2981268..2982401) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" promotor_-10 complement(2982434..2982453) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2982453) /Source="Nicolas_upshifts" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" promotor_-35 complement(2982466..2982475) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2982539..2982548 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2982562..2982581 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2982564 /Source="Nicolas_upshifts" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" CDS 2982591..2983664 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816, 20077512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 20077512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat kinase" /protein_id="NP_390970.1" /db_xref="EnsemblGenomes-Gn:BSU30920" /db_xref="EnsemblGenomes-Tr:CAB15070" /db_xref="GOA:O34656" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="PDB:2Q83" /db_xref="SubtiList:BG13821" /db_xref="UniProtKB/Swiss-Prot:O34656" /translation="MCPLMAENHEVIEEGNSSELPLSAEDAKKLTELAENVLQGWDVQ AEKIDVIQGNQMALVWKVHTDSGAVCLKRIHRPEKKALFSIFAQDYLAKKGMNVPGIL PNKKGSLYSKHGSFLFVVYDWIEGRPFELTVKQDLEFIMKGLADFHTASVGYQPPNGV PIFTKLGRWPNHYTKRCKQMETWKLMAEAEKEDPFSQLYLQEIDGFIEDGLRIKDRLL QSTYVPWTEQLKKSPNLCHQDYGTGNTLLGENEQIWVIDLDTVSFDLPIRDLRKMIIP LLDTTGVWDDETFNVMLNAYESRAPLTEEQKQVMFIDMLFPYELYDVIREKYVRKSAL PKEELESAFEYERIKANALRQLI*" gene 2982591..2983664 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" promotor_-35 2982888..2982894 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2982905 /Source="Nicolas_upshifts" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" promotor_-10 2982908..2982919 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2983653 /Source="Nicolas_upshifts" /id="D1591" /incds=0 /nref=16 /ntot=35 /MaxReadThrough="3.14769" /MaxDrop="5.1897" /score="-2.47616606" /energy="-10.3" /TU="U2396,U2397" /idTUdmin="U2396" /TUdmin="-528" /isTUend="FALSE" promotor_-35 2983691..2983697 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2983712 /Source="Nicolas_upshifts" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" promotor_-10 2983713..2983731 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2983744..2984211 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717291, 15849754, 16850406; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative receptor" /protein_id="NP_390971.1" /db_xref="EnsemblGenomes-Gn:BSU30930" /db_xref="EnsemblGenomes-Tr:CAB15071" /db_xref="GOA:O34694" /db_xref="InterPro:IPR004307" /db_xref="SubtiList:BG13822" /db_xref="UniProtKB/Swiss-Prot:O34694" /translation="MKKIVGALAVFVITYALFSAAGYLFPVDQEWYNSLKKPDWTPSG TAIGIIWAILFALISLSAAIVYAAFSFKGAKSFWFTLLINYVLNQAFSYFQFTQKNLL AASLDCLLVAITAIVLLIIAKKYSRAASYLLLPYFLWSAFATFLSFTINSMNL*" gene 2983744..2984211 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" downshifts 2984183 /Source="Nicolas_upshifts" /id="D1592" /incds=0 /nref=43 /ntot=123 /MaxReadThrough="2.47485" /MaxDrop="5.7907" /score="9.10214462" /energy="-10.1" /TU="NA" /idTUdmin="U2396" /TUdmin=2 /isTUend="TRUE" CDS complement(2984242..2986638) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" /EC_number="2.4.1.1" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8145641, 9244254, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen phosphorylase" /protein_id="NP_390972.1" /db_xref="EnsemblGenomes-Gn:BSU30940" /db_xref="EnsemblGenomes-Tr:CAB15072" /db_xref="GOA:P39123" /db_xref="InterPro:IPR000811" /db_xref="InterPro:IPR011833" /db_xref="InterPro:IPR035090" /db_xref="SubtiList:BG10911" /db_xref="UniProtKB/Swiss-Prot:P39123" /translation="MFSSKERFADLFLKRLEMTCGKSFKDSAKLDQYKTLGNMVREYI SADWIETNEKSRSNSGKQTYYLSIEFLLGQLLEQNLMNLGVRDVVEAGLKEIGINLEE ILQIENDAGLGNGGLGRLAACFLDSLASLNLPGHGMGIRYKHGLFEQKIVDGHQVELP EQWLKNGNVWEVRNADQAVDVPFWGEVHMTEKSGRLHFRHEQATIVTAVPYDIPIIGY ETGTVNTLRLWNAEPYAHYHGGNILSYKRETEAVSEFLYPDDTHDEGKILRLKQQYFL VCASLKSIVNNYRKTHKSLSGLHKKVSIHINDTHPALAVPELMRILLDEENMSWEEAW HITVHTISYTNHTTLSEALEKWPIHLFKPLLPRMYMIIEEINERFCRAVWEKYPGDWK RIENMAITAHGVVKMAHLAIVGSYSVNGVAKIHSDILKEREMRDFHLLFPNRFNNKTN GIAHRRWLLKANPGLSAIITEAIGDEWVKQPESLIRLEPYATDPAFIEQFQNNKSKKK QELADLIFCTAGVVVNPESIFDVQVKRLHAYKRQLLNVLHIMYLYNRLKEDSGFSIYP QTFIFGAKASPSYYYAKKIIKLIHSVAEKVNYDPAVKQLIKVVFLENYRVSMAERIFP ASDVSEQISTASKEASGTGNMKFMMNGALTIGTHDGANIEILERVGPDCIYTFGLKAD EVLSYQENGGYRSREYYQHDRRIRQVADQLINGFFEGEADEFESIFDSLLPHNDEYFV LKDFSSYADAQERIQADYRERRKWSEHSIVNIAHSGYFSSDRTIREYAKDIWGIKPMM *" gene complement(2984242..2986638) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" downshifts complement(2984257) /Source="Nicolas_upshifts" /id="D1593" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="2.31076" /MaxDrop="4.39135" /score="34.694666" /energy="-10.1" /TU="NA" /idTUdmin="U2399" /TUdmin=0 /isTUend="TRUE" CDS complement(2986625..2988079) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" /EC_number="2.4.1.21" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:8145641, 15272305" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8145641, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen (starch) synthase" /protein_id="NP_390973.1" /db_xref="EnsemblGenomes-Gn:BSU30950" /db_xref="EnsemblGenomes-Tr:CAB15073" /db_xref="GOA:P39125" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR011835" /db_xref="InterPro:IPR013534" /db_xref="SubtiList:BG10910" /db_xref="UniProtKB/Swiss-Prot:P39125" /translation="MKILFAVSECTPFVKSGGLADVAGALPKALARLGNEVAVMLPKY SQIPEPWKKRMKKQAECTVAVGWRQQYCGIEHMAENDVNYYFIDNEYYFNRDSLYGHY DDGERFAFFSRAVLEAAKVVNVQADIVHTHDWHTAMVNYLLKEEYRKHPFYERMKSVL TIHNLQFQGIFPPDVTHDLLGLEMDHFHYERLECNGFVNFMKAGIIAADHVTTVSPTY RNEIMTPYYGEQLEQVLQYREDDVTGILNGIDDTFYQPKSDPYIEAQYDSGDLACKLE NKTKLQQRMGLPEKNDIPLISMVTRLTKQKGLDLVRRIMHELLEEQDIQLVVLGTGER EFEDYFRYAEFAFHEKCRAYIGFDEPLAHQIYAGSDMFLMPSKFEPCGLGQLIALQYG AIPIVRETGGLYDTVRAYQEEEGTGNGFTFSAFNAHDLKFTIERALSFYCQQDVWKSI VKTAMNADYSWGKSAKEYQRIFEQVTRSGRDVLE*" gene complement(2986625..2988079) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" CDS complement(2988076..2989107) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) beta subunit" /protein_id="NP_390974.1" /db_xref="EnsemblGenomes-Gn:BSU30960" /db_xref="EnsemblGenomes-Tr:CAB15074" /db_xref="GOA:P39124" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011832" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10909" /db_xref="UniProtKB/Swiss-Prot:P39124" /translation="MFNNQMLGVIDETTYKHSLQDLTAQRSLGAIPFAGRYRLIDFML SNMVNADIRSVAIFPKYRYRSLMDHLGAGKEWDLHRKKDGLFFFPSPHLHHEYDEFGS FRQFSDHLDYFHRSTQQYAVISNSHTVCNIQFQYVLKRHQEVGCDVTEVFQDGQSLQI YIMSTTLLKDLIYGHSEKGYKTIQEAVEKESSALTICPYEYSGYAAVIDSVEKYYTHS MELIQPRFWQQVFLPQQPIYTKVKDEPPTKYGKHSTVKNSLVANGCVLEGEVENCILF RAVHVGKGTKLKNCIIMQKTQIGEDCLLEQVISDKDVKIGKATEAAGTAEQPLVLRKG LVQGELMNS*" gene complement(2988076..2989107) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" CDS complement(2989131..2990273) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) subunit alpha" /protein_id="NP_390975.1" /db_xref="EnsemblGenomes-Gn:BSU30970" /db_xref="EnsemblGenomes-Tr:CAB15075" /db_xref="GOA:P39122" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005836" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011831" /db_xref="InterPro:IPR023049" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10908" /db_xref="UniProtKB/Swiss-Prot:P39122" /translation="MKKQCVAMLLAGGKGSRLSGLTKNMAKPAVSFGGKYRIIDFTLS NCSNSGIDTVGILTQYQPLELNSYIGIGSAWDLDRYNGGVTVLPPYAESSEVKWYKGT ASSIYENLNYLNQYDPEYVLILSGDHIYKMDYGKMLDYHIEKKADVTISVIEVGWEEA SRFGIMKANPDGTITHFDEKPKFPKSNLASMGIYIFNWPLLKQYLEMDDQNPYSSHDF GKDIIPLLLEEKKKLSAYPFKGYWKDVGTVQSLWEANMDLLKEDSELKLFERKWKIYS VNPNQPPQFISSDAQVQDSLVNEGCVVYGNVSHSVLFQGVTVGKHTTVTSSVIMPDVT IGEHVVIENAIVPNGMVLPDGAVIRSEKDIEEVLLVSEEFVEKELI*" gene complement(2989131..2990273) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" CDS complement(2990270..2992153) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" /EC_number="2.4.1.18" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1296817, 15272305, 8145641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-alpha-glucan branching enzyme" /protein_id="NP_390976.1" /db_xref="EnsemblGenomes-Gn:BSU30980" /db_xref="EnsemblGenomes-Tr:CAB15076" /db_xref="GOA:P39118" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR006048" /db_xref="InterPro:IPR006407" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG10907" /db_xref="UniProtKB/Swiss-Prot:P39118" /translation="MAAASPTAHDVYLFHEGSLFKSYQLFGSHYRELNGKSGYEFCVW APHASEVRVAGDFNSWSGEEHVMHRVNDNGIWTLFIPGIGEKERYKYEIVTNNGEIRL KADPYAIYSEVRPNTASLTYDLEGYSWQDQKWQKKQKAKTLYEKPVFIYELHLGSWKK HSDGRHYSYKELSQTLIPYIKKHGFTHIELLPVYEHPYDRSWGYQGTGYYSPTSRFGP PHDLMKFVDECHQQNIGVILDWVPGHFCKDAHGLYMFDGEPLYEYKEERDRENWLWGT ANFDLGKPEVHSFLISNALYWAEFYHIDGFRVDAVANILYWPNQDERHTNPYAVDFLK KLNQTMREAYPHVMMIAEDSTEWPQVTGAVEEGGLGFHYKWNMGWMNDVLKYMETPPE ERRHCHQLISFSLLYAFSEHFVLPFSHDEVVYGKKSLLNKMPGDYWQKFAQYRLLLGY MTVHPGKKLIFMGSEFAQFDEWKDTEQLDWFLDSFPMHQKASVFTQDLLRFYQKSKIL YEHDHRAQSFEWIDVHNDEQSIFSFIRYGQKHGEALVIICNFTPVVYHQYDVGVPFFT QYIEVLNSDSETYGGSGQINKKPLSAKKGALHHKPCYITMTIPPYGISILRAVKKRGE IKR*" gene complement(2990270..2992153) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" S_feature 2990979..2992398 /Source="Nicolas_S_feature" /locus_tag="new_3170472_3171891" /HighExp="S8, S7, S6, C30, BT, Pyr, G/S, S2, C90, BC" /AntisenseName="glgB" /AntisenseCor="0.59299722159013002" /AntisenseRegPval="-26.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1180" promotor_-10 complement(2992185..2992200) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2992198) /Source="Nicolas_upshifts" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" promotor_-35 complement(2992215..2992220) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2992265) /Source="Nicolas_upshifts" /id="D1594" /incds=0 /nref=2 /ntot=46 /MaxReadThrough="1.66182" /MaxDrop="3.12741" /score="36.0363304" /energy="-9.2" /TU="NA" /idTUdmin="U2401" /TUdmin=198 /isTUend="FALSE" tRNA complement(2992386..2992457) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2992386..2992457) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" tRNA complement(2992483..2992573) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2992483..2992573) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" tRNA complement(2992577..2992651) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2992577..2992651) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" tRNA complement(2992662..2992738) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2992662..2992738) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" tRNA complement(2992754..2992827) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2992754..2992827) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" tRNA complement(2992838..2992913) /gene="trnB-His" /locus_tag="BSU_tRNA_67" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2992838..2992913) /gene="trnB-His" /locus_tag="BSU_tRNA_67" tRNA complement(2992931..2993006) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2992931..2993006) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" tRNA complement(2993019..2993095) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2993019..2993095) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" tRNA complement(2993107..2993183) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2993107..2993183) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" tRNA complement(2993201..2993293) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2993201..2993293) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" tRNA complement(2993300..2993376) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2993300..2993376) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" tRNA complement(2993379..2993455) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2993379..2993455) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" tRNA complement(2993475..2993547) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2993475..2993547) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" tRNA complement(2993553..2993629) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2993553..2993629) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" tRNA complement(2993645..2993721) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2993645..2993721) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" tRNA complement(2993731..2993816) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2993731..2993816) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" tRNA complement(2993831..2993905) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2993831..2993905) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" tRNA complement(2993911..2993997) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2993911..2993997) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" tRNA complement(2994008..2994083) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2994008..2994083) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" tRNA complement(2994121..2994196) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2994121..2994196) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" tRNA complement(2994229..2994304) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2994229..2994304) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" rRNA complement(2994325..2994442) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2994325..2994442) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" rRNA complement(2994498..2997425) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2994498..2997425) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" rRNA complement(2997593..2999147) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2997593..2999147) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" S_feature complement(2999148..2999439) /Source="Nicolas_S_feature" /locus_tag="new_3178641_3178932_c" /HighExp="Diami, LPhT, C30, LBGstat, HPh, GM 120, Oxctl, Paraq, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40784100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1181" misc_feature 2999275..2999283 /Source="Nicolas_upshift_promotors" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2999281 /Source="Nicolas_upshifts" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2999391 /Source="Nicolas_upshifts" /id="D1595" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="2.91899" /MaxDrop="4.63941" /score="-0.368124787" /energy="-10.2" /TU="U2400" /idTUdmin="U2400" /TUdmin="-22" /isTUend="TRUE" promotor_-10 complement(2999412..2999431) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2999439) /Source="Nicolas_upshifts" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" S_feature complement(2999441..3000407) /Source="Nicolas_S_feature" /locus_tag="new_3178934_3179900_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T0.0H, T3.0H, T-0.40H, S8, T3.30H" /AntisenseName="thiT" /AntisenseCor="-0.219467435413819" /AntisenseRegPval="-3.5" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1182" promotor_-35 complement(2999445..2999452) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2999564..2999567 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2999579 /Source="Nicolas_upshifts" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" promotor_-10 2999582..2999601 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2999612..2999713 /gene="tswC" /locus_tag="BSU_misc_RNA_51" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" gene 2999612..2999713 /gene="tswC" /locus_tag="BSU_misc_RNA_51" downshifts 2999712 /Source="Nicolas_upshifts" /id="D1596" /incds=0 /nref=47 /ntot=135 /MaxReadThrough="5.85975" /MaxDrop="7.03111" /score="-0.368124787" /energy="-10.2" /TU="U2402" /idTUdmin="U2400" /TUdmin=299 /isTUend="FALSE" CDS 2999813..3000391 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 19181806" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 19181806; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamin permease" /protein_id="NP_390977.1" /db_xref="EnsemblGenomes-Gn:BSU30990" /db_xref="EnsemblGenomes-Tr:CAB15077" /db_xref="GOA:O32074" /db_xref="InterPro:IPR012651" /db_xref="SubtiList:BG13949" /db_xref="UniProtKB/Swiss-Prot:O32074" /translation="MNQSKQLVRLIEIAIMTAAAVILDIVSGMFLSMPQGGSVSIMMI PIFLISFRWGVKAGLTTGLLTGLVQIAIGNLFAQHPVQLLLDYIVAFAAIGISGCFAS SVRKAAVSKTKGKLIVSVVSAVFIGSLLRYAAHVISGAVFFGSFAPKGTPVWIYSLTY NATYMVPSFIICAIVLCLLFMTAPRLLKSDKA*" gene 2999813..3000391 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" downshifts 3000381 /Source="Nicolas_upshifts" /id="D1597" /incds=0 /nref=129 /ntot=206 /MaxReadThrough="1.91553" /MaxDrop="5.49387" /score="35.5376279" /energy="-19.5" /TU="NA" /idTUdmin="U2402" /TUdmin=0 /isTUend="TRUE" CDS complement(3000433..3000954) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390978.1" /db_xref="EnsemblGenomes-Gn:BSU31000" /db_xref="EnsemblGenomes-Tr:CAB15078" /db_xref="GOA:O32075" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13948" /db_xref="UniProtKB/Swiss-Prot:O32075" /translation="MVTVREAKLEDIKDIAKVHVDSWRTTYHEIIPIDYLNSLNYKEF EDKWKSRSLKGVFVAQDEKGSVFGFASFGPIRSEQEGYDGELYAIYLLEERQRQGAGR ALLAKGAEFLLQHGFSSMFVWVIEQNPSIIFYQAYSPERVAEDNFEIAGVRLKEVGLG WPDLSALKTLLNR*" gene complement(3000433..3000954) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" downshifts complement(3000451) /Source="Nicolas_upshifts" /id="D1598" /incds=0 /nref=8 /ntot=143 /MaxReadThrough="6.18352" /MaxDrop="5.43101" /score="13.1646679" /energy="-19.6" /TU="U2403" /idTUdmin="U2405" /TUdmin=6 /isTUend="TRUE" downshifts complement(3000523) /Source="Nicolas_upshifts" /id="D1599" /incds=1 /nref=8 /ntot=208 /MaxReadThrough="8.2849" /MaxDrop="3.3545" /score="13.1646679" /energy="-19.6" /TU="U2403,U2405" /idTUdmin="U2405" /TUdmin="-66" /isTUend="FALSE" CDS complement(3000972..3002501) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" /experiment="publication(s) with functional evidences, PMID:9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845; Product type s: structure" /codon_start=1 /transl_table=11 /product="flotillin lipid rafts scaffold protein" /protein_id="NP_390979.1" /db_xref="EnsemblGenomes-Gn:BSU31010" /db_xref="EnsemblGenomes-Tr:CAB15079" /db_xref="GOA:O32076" /db_xref="InterPro:IPR001107" /db_xref="InterPro:IPR027705" /db_xref="InterPro:IPR031905" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG13947" /db_xref="UniProtKB/Swiss-Prot:O32076" /translation="MTMPIIMIIGVVFFLLIALIAVFITKYRTAGPDEALIVTGSYLG NKNVHVDEGGNRIKIVRGGGTFVLPVFQQAEPLSLLSSKLDVSTPEVYTEQGVPVMAD GTAIIKIGGSIGEIATAAEQFLGKSKDDREQEAREVLEGHLRSILGSMTVEEIYKNRE KFSQEVQRVASQDLAKMGLVIVSFTIKDVRDKNGYLESLGKPRIAQVKRDADIATAEA DKETRIKRAEADKDAKKSELERATEIAEAEKINQLKMAEFRREQDTAKANADQAYDLE TARARQQVTEQEMQVKIIERQKQIELEEKEILRRERQYDSEVKKKADADRYSVEQSAA AEKAKQLAEADAKKYSIEAMAKAEAEKVRIDGLAKAEAEKAKGETEAEVIRLKGLAEA EAKEKIAAAFEQYGQAAIFDMIVKMLPEYAKQAAAPLSNIDKITVVDTGGSGESSGAN KVTSYATNLMSSLQESLKASSGIDVKEMLENFSGKGNVKQSINELTNEIKEAKTIQKS E*" gene complement(3000972..3002501) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" CDS complement(3002522..3003046) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12533473, 15849754, 16850406, 18696230, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane integrity integral membrane protein" /protein_id="NP_390980.1" /db_xref="EnsemblGenomes-Gn:BSU31020" /db_xref="EnsemblGenomes-Tr:CAB15080" /db_xref="GOA:O32077" /db_xref="PDB:2K14" /db_xref="SubtiList:BG13946" /db_xref="UniProtKB/Swiss-Prot:O32077" /translation="MELFGVPIQTMYLYTLIIAGSLTLLFLFFGDVFSGLSEGIPFLN PTLVLSFFTCFSAGGYIGELVLPLSSLLIALLSCILSIMLVVLLHIFVLVPLSSAEES LAYREDDLRGRLGKVITAVPVDGFGEVVIEGIGGTISKSAVSFDNQQISYGTTVLVVD INNGVLSVTPHEPI*" gene complement(3002522..3003046) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" promotor_-10 complement(3003090..3003105) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-10" upshifts complement(3003096) /Source="Nicolas_upshifts" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" S_feature complement(3003098..3003185) /Source="Nicolas_S_feature" /locus_tag="new_3182591_3182678_c" /HighExp="S4, S8, S6, S7, S5, S3, B36, LoTm, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S1183" promotor_-35 complement(3003117..3003126) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-35" promotor_-10 complement(3003170..3003188) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3003180 /Source="Nicolas_upshifts" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" misc_feature 3003184..3003203 /Source="Nicolas_upshift_promotors" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3003185) /Source="Nicolas_upshifts" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" promotor_-35 complement(3003203..3003208) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3003214..3003702 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390981.1" /db_xref="EnsemblGenomes-Gn:BSU31030" /db_xref="EnsemblGenomes-Tr:CAB15081" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG13945" /db_xref="UniProtKB/Swiss-Prot:O32078" /translation="MSIFNEARLETWNELKGLSDEKLNQKPSAEEWSIREVLDHLKKI DMTAQKMLKERVKDAPIKEIEEKPLEVAQDRNNKRKAPSHLEPAHDFISGSQMKRELD VVREQLTAAIASLKEEDFERVLPHPVFQELTVRQWIDFIGHHEKRHLSQMKEIKEKIE RA*" gene 3003214..3003702 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" downshifts 3003679 /Source="Nicolas_upshifts" /id="D1600" /incds=0 /nref=205 /ntot=267 /MaxReadThrough="4.05856" /MaxDrop="6.05192" /score="-4.20632485" /energy="-15" /TU="U2404" /idTUdmin="U2404" /TUdmin="-354" /isTUend="FALSE" CDS complement(3003708..3004286) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11886751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390982.1" /db_xref="EnsemblGenomes-Gn:BSU31040" /db_xref="EnsemblGenomes-Tr:CAB15082" /db_xref="GOA:O32079" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="PDB:1ORU" /db_xref="SubtiList:BG13944" /db_xref="UniProtKB/Swiss-Prot:O32079" /translation="MWKRMTAKAEGLYIADTKSFVTKQMDKLDFDYGGIPGDLHFGLT KKAGAREPMFSRGTEIFNRRQISIVSIEECNEIALKMGVPRILPEWLGANVAVSGMPD LTSLKEGSRIIFPSGAALLCEGENDPCIQPGEVIQSYYPDQPKLASAFVRHALGIRGI VCIVERPGAVYTGDEIEVHSYQRKVKRKAERV*" gene complement(3003708..3004286) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" S_feature 3003724..3004115 /Source="Nicolas_S_feature" /locus_tag="new_3183217_3183608" /HighExp="Etha, S8, LPhT, S6, Salt, LoTm, S5, H2O2, S7, dia5" /AntisenseName="yuaD" /AntisenseCor="-0.48344313728748101" /AntisenseRegPval="-16.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.962" /TUlongSig="NA" /TUlongPSig="NA" /label="S1184" downshifts complement(3003735) /Source="Nicolas_upshifts" /id="D1601" /incds=0 /nref=87 /ntot=222 /MaxReadThrough="0.58189" /MaxDrop="3.9885" /score="0.718873117" /energy="-11.5" /TU="NA" /idTUdmin="U2406" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3004320..3004339) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3004329) /Source="Nicolas_upshifts" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" promotor_-35 complement(3004353..3004360) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3004374..3005582) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" /EC_number="1.1.99.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="choline dehydrogenase" /protein_id="NP_390983.2" /db_xref="EnsemblGenomes-Gn:BSU31050" /db_xref="EnsemblGenomes-Tr:CAB15083" /db_xref="GOA:P71017" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG11941" /db_xref="UniProtKB/Swiss-Prot:P71017" /translation="MTLNMKVESMQKFHTFEIPTVIKHGIGAIKHTGEEVAALGVSKA LLVTDPGIYKAGVADPVIESLKEAGIEVVLFNKVEPNPPVRLVNEGSELYKKENCNGL VAVGGGSSMDTAKAIGVEATHEGSVLDYEAADGKKPLENRIPPLTTIPTTAGTGSEVT QWAVITDEEREFKFNTGGPLIAAHLTIIDPELHVSMPPHVTAMTGIDALAHAIECYTM KFAQPITDAVALMAIEYAAHYIKRAFADGEDLEARYGMAQAAMLAGLSYGSESAGAAH AMSQTLGGIIPVAHGQCVAAMMGPVMEYNWKGYPEKFARIAKAFGIDTSKMTTEEAAK ASVNWMYDLVEDLEVPTLEEQGVSPDMIERLSKEAMKDPQTFGNPRDLNEKAYNWIYK RCFNLTPKTV*" gene complement(3004374..3005582) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" downshifts complement(3004395) /Source="Nicolas_upshifts" /id="D1602" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="2.9443" /MaxDrop="3.26923" /score="18.315772" /energy="-13.6" /TU="NA" /idTUdmin="U2406" /TUdmin="-660" /isTUend="FALSE" promotor_-10 complement(3005351..3005370) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3005363) /Source="Nicolas_upshifts" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3005385..3005392) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3005599..3007071) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" /EC_number="1.2.1.8" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 9297465, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 9297465, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine betaine aldehyde dehydrogenase, NAD+-dependent" /protein_id="NP_390984.1" /db_xref="EnsemblGenomes-Gn:BSU31060" /db_xref="EnsemblGenomes-Tr:CAB15084" /db_xref="GOA:P71016" /db_xref="InterPro:IPR011264" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11940" /db_xref="UniProtKB/Swiss-Prot:P71016" /translation="MSQTLFIDGEWISAEKEQIRSIINPFNQEEIATVSEGGREDAIK AIAAARRAFDKGEWSSLSGLERGKIVLKIAELIRRDLEELAELESLDTGKTLEESKAD MDDIANVFQYYAGLADKDGGEIISSPIPDSESKIIREPIGVCGQITPWNYPLLQASWK IAPALAAGNTIVMKPSEITPLTTIKVFKLMEEAGVPKGVANLVLGPGATVGDELAVNK DVDLISFTGGIETGKKIMRAASGNVKKIALELGGKNPNIVFKDADLEVAVDQALNAVF FHAGQVCSAGSRLLVEDAIHDQFLAELVKRAKRIKLGNGFHAETESGPLISAEHRAKV EKYVEIGIEEGAKLETGGKRPEDPELQNGFFYEPTIFSNCNSDMRIVQEEVFGPVLTV ETFSSEEEVIELANDTIYGLAGAVWSKDIEKCERVAARLRMGTVWINDFHPYFAQAPW GGYKQSGFGRELGKIGLEEYTEVKHVYRNTKPAAVNWFNS*" gene complement(3005599..3007071) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" promotor_-10 complement(3007122..3007141) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3007123) /Source="Nicolas_upshifts" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" promotor_-35 complement(3007156..3007163) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3007183..3007189 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3007203..3007222 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3007218 /Source="Nicolas_upshifts" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" CDS 3007270..3007812 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor for gbsAB" /protein_id="NP_390985.1" /db_xref="EnsemblGenomes-Gn:BSU31070" /db_xref="EnsemblGenomes-Tr:CAB15085" /db_xref="GOA:P71015" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12342" /db_xref="UniProtKB/Swiss-Prot:P71015" /translation="MDENPEFAAIEQARDLVIDSIAETMDLYGITRSVGILYGTMYMR DEMTLDEMREELQMSKPSMSTGVKKLQDLNVVKKTFHRGIRKHTFVAEKDFFKFFTNF FPPKWEREVQVNVTAIEEAQADLQKVLCKEDLDEDIKNEALQLYDQLESSKAYYDWLK RLAESVQTGEIFKFIPVETK*" gene 3007270..3007812 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" downshifts 3007795 /Source="Nicolas_upshifts" /id="D1603" /incds=0 /nref=74 /ntot=220 /MaxReadThrough="1.70461" /MaxDrop="3.5918" /score="26.1509691" /energy="-9.9" /TU="NA" /idTUdmin="U2409" /TUdmin=0 /isTUend="TRUE" promotor_-35 3007889..3007896 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3007909..3008009 /Source="Nicolas_S_feature" /locus_tag="new_3187402_3187502" /HighExp="BT, S0, BI, T-1.10H, T-1.40H, T1.0H, T-0.40H, T0.0H, S2, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1185" upshifts 3007909 /Source="Nicolas_upshifts" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" promotor_-10 3007911..3007930 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3008010..3008555 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" /function="15.3: Cell adhesion" /experiment="publication(s) with functional evidences, PMID:21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732; Product type s: structure" /codon_start=1 /transl_table=11 /product="biofilm hydrophobic layer component" /protein_id="NP_390986.1" /db_xref="EnsemblGenomes-Gn:BSU31080" /db_xref="EnsemblGenomes-Tr:CAB15086" /db_xref="GOA:P71014" /db_xref="InterPro:IPR034650" /db_xref="PDB:4BHU" /db_xref="SubtiList:BG12341" /db_xref="UniProtKB/Swiss-Prot:P71014" /translation="MKRKLLSSLAISALSLGLLVSAPTASFAAESTSTKAHTESTMRT QSTASLFATITGASKTEWSFSDIELTYRPNTLLSLGVMEFTLPSGFTANTKDTLNGNA LRTTQILNNGKTVRVPLALDLLGAGEFKLKLNNKTLPAAGTYTFRAENKSLSIGNKFY AEASIDVAKRSTPPTQPCGCN*" gene 3008010..3008555 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" downshifts 3008542 /Source="Nicolas_upshifts" /id="D1604" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="0.85027" /MaxDrop="6.00835" /score="20.8976757" /energy="-10.2" /TU="NA" /idTUdmin="U2410" /TUdmin="-1" /isTUend="TRUE" promotor_-35 3008647..3008654 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3008668..3008687 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3008675 /Source="Nicolas_upshifts" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" misc_RNA 3008680..3008848 /gene="swdA" /locus_tag="BSU_misc_RNA_52" /product="cyclic-di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751; Product type n: RNA" gene 3008680..3008848 /gene="swdA" /locus_tag="BSU_misc_RNA_52" downshifts 3008829 /Source="Nicolas_upshifts" /id="D1605" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="6.04086" /MaxDrop="4.75274" /score="3.29445061" /energy="-6.1" /TU="U2411" /idTUdmin="U2410" /TUdmin=286 /isTUend="FALSE" CDS 3008921..3009589 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 23598340, 23671116, 25957408, 26771197" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 23598340, 23671116, 25957408, 26771197; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_390987.1" /db_xref="EnsemblGenomes-Gn:BSU31090" /db_xref="EnsemblGenomes-Tr:CAB15087" /db_xref="GOA:O32080" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="PDB:1LSU" /db_xref="PDB:2HMS" /db_xref="PDB:2HMT" /db_xref="PDB:2HMU" /db_xref="PDB:2HMV" /db_xref="PDB:2HMW" /db_xref="PDB:4J7C" /db_xref="PDB:4J90" /db_xref="PDB:4J91" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13943" /db_xref="UniProtKB/Swiss-Prot:O32080" /translation="MGRIKNKQFAVIGLGRFGGSICKELHRMGHEVLAVDINEEKVNA YASYATHAVIANATEENELLSLGIRNFEYVIVAIGANIQASTLTTLLLKELDIPNIWV KAQNYYHHKVLEKIGADRIIHPEKDMGVKIAQSLSDENVLNYIDLSDEYSIVELLATR KLDSKSIIDLNVRAKYGCTILAIKHHGDICLSPAPEDIIREQDCLVIMGHKKDIKRFE NEGM*" gene 3008921..3009589 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" CDS 3009596..3010933 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium transporter ATPase" /protein_id="NP_390988.1" /db_xref="EnsemblGenomes-Gn:BSU31100" /db_xref="EnsemblGenomes-Tr:CAB15088" /db_xref="GOA:O32081" /db_xref="InterPro:IPR003445" /db_xref="InterPro:IPR004772" /db_xref="PDB:4J7C" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13956" /db_xref="UniProtKB/Swiss-Prot:O32081" /translation="MTLQKDKVIKWVRFTPPQVLAIGFFLTIIIGAVLLMLPISTTKP LSWIDALFTAASATTVTGLAVVDTGTQFTVFGQTVIMGLIQIGGLGFMTFAVLIVMIL GKKIGLKERMLVQEALNQPTIGGVIGLVKVLFLFSISIELIAALILSIRLVPQYGWSS GLFASLFHAISAFNNAGFSLWPDNLMSYVGDPTVNLVITFLFITGGIGFTVLFDVMKN RRFKTFSLHTKLMLTGTLMLNAIAMLTVFILEYSNPGTLGHLHIVDKLWASYFQAVTP RTAGFNSLDFGSMREGTIVFTLLLMFIGAGSASTASGIKLTTFIVILTSVIAYLRGKK ETVIFRRSIKYPIIIKALAVSVTSLFIVFLGIFALTITEQAPFLQIVFETFSAFGTVG LTMGLTPELTTAGKCIIIVIMFIGRIGPLTFVFSFAKTEQSNIRYPDGEVFTG*" gene 3009596..3010933 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" downshifts 3010919 /Source="Nicolas_upshifts" /id="D1606" /incds=0 /nref=9 /ntot=98 /MaxReadThrough="0.86883" /MaxDrop="3.37604" /score="25.8974852" /energy="-11.9" /TU="NA" /idTUdmin="U2411" /TUdmin=0 /isTUend="TRUE" CDS complement(3010969..3011232) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390989.1" /db_xref="EnsemblGenomes-Gn:BSU31110" /db_xref="EnsemblGenomes-Tr:CAB15089" /db_xref="GOA:O32082" /db_xref="InterPro:IPR008024" /db_xref="SubtiList:BG13955" /db_xref="UniProtKB/Swiss-Prot:O32082" /translation="MQKYRRRNTVAFTVLAYFTFFAGVFLFSIGLYNADNLELNEKGY YIAVMILVAVGAILTQKVTRDNAEDNEIIAEQEKRQNQSHIES*" gene complement(3010969..3011232) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" downshifts complement(3010987) /Source="Nicolas_upshifts" /id="D1607" /incds=0 /nref=237 /ntot=309 /MaxReadThrough="2.4577" /MaxDrop="7.13564" /score="30.2020977" /energy="-11.9" /TU="NA" /idTUdmin="U2412" /TUdmin="-14" /isTUend="TRUE" promotor_-10 complement(3011272..3011291) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3011274) /Source="Nicolas_upshifts" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" promotor_-35 complement(3011304..3011311) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3011341..3012189) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" /EC_number="3.2.1.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12525152, 16855244, 28448118, 28811162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12525152, 16855244, 28448118, 28811162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exoglucosaminidase" /protein_id="NP_390990.1" /db_xref="EnsemblGenomes-Gn:BSU31120" /db_xref="EnsemblGenomes-Tr:CAB15090" /db_xref="GOA:O32083" /db_xref="InterPro:IPR002901" /db_xref="InterPro:IPR025987" /db_xref="SubtiList:BG13954" /db_xref="UniProtKB/Swiss-Prot:O32083" /translation="MARKKLKKRKLLISLFFLVSIPLALFVLATTLSKPIEISKETEE IDEQQVFIDSLSGHAQILYEKYHVLPSITIAQAILESDWGNSELAAKANNLFGVKGNY KGHHVTMETDEVEKGKRKTIRAKFRKYSTFFESMDDHAQLFVRGTSWNKKKYKPVLEA GNYKEAATALQTSGYATDPDYADKISAIVEKYDLDEYDEVNPSLKSVDLNASIKDSAV QDVWSKPSTDDRSIRLTSAQSYVGKDIKVVSKKQKGQSVWYQFQINDKLIGWIDDSAV EIKEAT*" gene complement(3011341..3012189) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" promotor_-10 complement(3012234..3012253) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3012244) /Source="Nicolas_upshifts" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" promotor_-35 complement(3012268..3012275) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3012350..3013885) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28248504; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390991.1" /db_xref="EnsemblGenomes-Gn:BSU31130" /db_xref="EnsemblGenomes-Tr:CAB15091" /db_xref="GOA:O32084" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13953" /db_xref="UniProtKB/Swiss-Prot:O32084" /translation="MKTKHYWVISLLAVLAVGPGLMSNTALSSVQGLVQKTVGTSVFT SVNPILIGNMAFALLVPAGPLLRKKFGARPVYLASLPVFILGSLLIACSGDIALMAAG RFLQGAATGVMLMIMIPMLVLSFPIERRNYALLVLIGGFYGSVIIGTILGTIATSCGH WRWLFFIFGTLSLIGVAVSYFFLHDEHHGAADQEQPLDRAGILLSVFLAAASAVSFIF LQKWGLSSGYVWIGFGVTLCLLIGLLIVEYKVKNPFISIKLMLLPKPVLGLLIIAAGT ITVAVSLSAFQGLLRQMYDISQEHLILLSLTLLIGVAIAAILSALLYDKVGPGMLGII GGLILVFVNFQWLHIQDRSSLYMFAALFIMLAAGTGLTVAAGLMGAAMGGPLPDLVKR MTAVQFLRLFVYMGVPILIGFFTKKDAARQSGSVQDSMMTAYHDLFFISFILSVLLVC LSFCMNATGMGHKLAHKPHDKAKTAPEKPAVSAQGLSKATVKSYKVINDTEYRNALRN LQK*" gene complement(3012350..3013885) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" downshifts complement(3012359) /Source="Nicolas_upshifts" /id="D1608" /incds=0 /nref=45 /ntot=159 /MaxReadThrough="1.39941" /MaxDrop="4.26166" /score="-3.3162201" /energy="-5.7" /TU="NA" /idTUdmin="U2415" /TUdmin=0 /isTUend="TRUE" promotor_no_box 3013543..3013643 /Source="Nicolas_upshift_promotors" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3013603 /Source="Nicolas_upshifts" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 3013669 /Source="Nicolas_upshifts" /id="D1609" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="0.0870599999999992" /MaxDrop="3.19459" /score="-1.6836786" /energy="-10.4" /TU="NA" /idTUdmin="U2416" /TUdmin="-1496" /isTUend="FALSE" S_feature complement(3013886..3014053) /Source="Nicolas_S_feature" /locus_tag="new_3193379_3193546_c" /HighExp="Cold, S8, G180, UNK1, C30, G135, S7, Lbexp, MG 25, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34877900000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1186" promotor_-10 complement(3014042..3014061) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3014053) /Source="Nicolas_upshifts" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" S_feature complement(3014055..3014932) /Source="Nicolas_S_feature" /locus_tag="new_3193548_3194425_c" /HighExp="G180, Cold, C30, G135, Paraq, Oxctl, S8, G150, H2O2, Heat" /AntisenseName="cdoA" /AntisenseCor="-2.3104546834536201E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1187" promotor_-35 complement(3014076..3014083) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3014295..3014304 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3014318..3014337 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3014318 /Source="Nicolas_upshifts" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" CDS 3014370..3014855 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" /EC_number="1.13.11.20" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10939241, 15699190, 16855246, 25307852, 26590284" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15699190, 16855246, 25307852, 26590284; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine dioxygenase" /protein_id="NP_390992.1" /db_xref="EnsemblGenomes-Gn:BSU31140" /db_xref="EnsemblGenomes-Tr:CAB15092" /db_xref="GOA:O32085" /db_xref="InterPro:IPR010300" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:3EQE" /db_xref="PDB:4QM8" /db_xref="PDB:4QM9" /db_xref="SubtiList:BG13952" /db_xref="UniProtKB/Swiss-Prot:O32085" /translation="MELYECIQDIFGGLKNPSVKDLATSLKQIPNAAKLSQPYIKEPD QYAYGRNAIYRNNELEIIVINIPPNKETTVHDHGQSIGCAMVLEGKLLNSIYRSTGEH AELSNSYFVHEGECLISTKGLIHKMSNPTSERMVSLHVYSPPLEDMTVFEEQKEVLEN S*" gene 3014370..3014855 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" S_feature 3014856..3015142 /Source="Nicolas_S_feature" /locus_tag="new_3194349_3194635" /HighExp="S6, S8, S7, BT, S5, G/S, C30, Pyr, C90, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.53171800000000002" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1188" tRNA complement(3014962..3015034) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala (GGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" gene complement(3014962..3015034) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" downshifts complement(3014977) /Source="Nicolas_upshifts" /id="D1610" /incds=0 /nref=37 /ntot=180 /MaxReadThrough="3.88031" /MaxDrop="4.38957" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=154 /isTUend="FALSE" downshifts complement(3015021) /Source="Nicolas_upshifts" /id="D1611" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.34085" /MaxDrop="4.19639" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=110 /isTUend="FALSE" promotor_-10 complement(3015045..3015064) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3015065) /Source="Nicolas_upshifts" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" promotor_-35 complement(3015079..3015082) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3015099 /Source="Nicolas_upshifts" /id="D1612" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="3.04964" /MaxDrop="3.22361" /score="-1.6836786" /energy="-10.4" /TU="U2416" /idTUdmin="U2416" /TUdmin="-66" /isTUend="FALSE" CDS complement(3015142..3015972) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" /EC_number="3.6.1.27" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15138271, 15849754, 16850406, 27528508, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15138271, 15849754, 16850406, 27528508, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl-pyrophosphate phosphatase" /protein_id="NP_390993.1" /db_xref="EnsemblGenomes-Gn:BSU31150" /db_xref="EnsemblGenomes-Tr:CAB15093" /db_xref="GOA:P94507" /db_xref="InterPro:IPR003824" /db_xref="SubtiList:BG13951" /db_xref="UniProtKB/Swiss-Prot:P94507" /translation="MTLWELFVAAILGIVEGLTEYAPVSSTGHMIIVDDIWLKSSNLM SEEAANSFKVVIQLGSILAVAIVFKDRILNLLGLKKNITSDQEQGHKLSIAQIAVGLV PAAVLGFLFEDYIDEYLFSVKTVAIGLIAGAILMLFADWVNKRKTATDTLDRISYKQA IAVGLFQCLSLWPGFSRSGSTISGGVILGLNHRAAADFTFIMAMPIMMGASFLSLVKH WDSLSSDLMPFFIVGFICAFVVALFVVRFFLRLINKIKLVPFAIYRIILGVILLLIMM *" gene complement(3015142..3015972) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" downshifts complement(3015153) /Source="Nicolas_upshifts" /id="D1613" /incds=0 /nref=60 /ntot=208 /MaxReadThrough="3.0552" /MaxDrop="5.61932" /score="-4.25033697" /energy="-6.7" /TU="U2419" /idTUdmin="U2419" /TUdmin="-22" /isTUend="TRUE" S_feature complement(3015973..3016064) /Source="Nicolas_S_feature" /locus_tag="new_3195466_3195557_c" /HighExp="dia15, H2O2, Salt, Etha, dia5, LBGtran, M0t90, Lbstat, Mt0, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1189" CDS complement(3016065..3017231) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16385049, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390994.1" /db_xref="EnsemblGenomes-Gn:BSU31160" /db_xref="EnsemblGenomes-Tr:CAB15094" /db_xref="GOA:O32086" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13950" /db_xref="UniProtKB/Swiss-Prot:O32086" /translation="METLQTWSGRFKRFFLDNKFVLFLLVLLLIGLNILVFTKTSFIF TPIIVLLKTISLPIILTGIVFYLLNPVVDFLERRRIRRIYSILLLYLLVIGLITITIV SIIPFLKEQIMSLIDNIPRYVDVVENQTKQLIGSNFVNQAQQTMNINISDLATKVSDQ AATIVNSTFTGVGNFIGALTEIIISIVTVPFILFYLLKDGRKLPVYILKFVPTRLKEQ TYTVLSEMNHRLSSYIRGQIIVSFCIGFLLFIGYLIIGLDYASLLAVIAACTSIVPYL GPTIAITPAIIIAIVTSPLMLLKLVIVWTIVQLIEGKLISPQIMGKNLHIHPITIIFL LLTAGKLFGVVGIILAIPGYAVAKVITTHLFDWFKMQSHLYDEEKNENTPGHKV*" gene complement(3016065..3017231) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" promotor_-35 3017227..3017231 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3017239..3017253 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3017255..3017274) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3017255 /Source="Nicolas_upshifts" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(3017274) /Source="Nicolas_upshifts" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" promotor_-35 complement(3017288..3017295) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3017353..3017360 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3017366 /Source="Nicolas_upshifts" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" promotor_-10 3017371..3017390 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3017413..3018399 /gene="iolU" /locus_tag="BSU_31170" /old_locus_tag="BSU31170" /EC_number="1.1.1.371" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12450853, 28043209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450853, 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol dehydrogenase (NADP+-dependent);biofilm formation" /protein_id="NP_390995.1" /db_xref="EnsemblGenomes-Gn:BSU31170" /db_xref="EnsemblGenomes-Tr:CAB15095" /db_xref="GOA:O05265" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12388" /db_xref="UniProtKB/Swiss-Prot:O05265" /translation="MIRFAIIGTNWITDRFLESAADIEDFQLTAVYSRSAERAGEFAA KHNAAHAFSDLQEMAASDCFDAVYIASPNALHKEQAVLFMNHGKHVLCEKPFASNTKE TEEMISAAKANGVVLMEAMKTTFLPNFKELKKHLHKIGTVRRFTASYCQYSSRYDAFR SGTVLNAFQPELSNGSLMDIGVYCIYPAVVLFGAPKDVKANGYALSSGVDGEGTVILS YDGFEAVLMHSKISTSYAPAEIQGEDGTIVIDTIHRPERVEIRYRDGRLENIAIPDPK PAMFYEAEEFVTLIKENKLESEENTFERSLTTAKIMEEARKQMGIVYPADQA*" gene 3017413..3018399 /gene="iolU" /locus_tag="BSU_31170" /old_locus_tag="BSU31170" downshifts 3018370 /Source="Nicolas_upshifts" /id="D1614" /incds=0 /nref=30 /ntot=279 /MaxReadThrough="1.83109" /MaxDrop="4.96985" /score="21.8997198" /energy="-15.1" /TU="NA" /idTUdmin="U2420" /TUdmin="-7" /isTUend="TRUE" CDS complement(3018440..3019714) /gene="rhaA" /locus_tag="BSU_31180" /old_locus_tag="BSU31180" /EC_number="5.3.1.14" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960106, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960106, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-rhamnose isomerase" /protein_id="NP_390996.1" /db_xref="EnsemblGenomes-Gn:BSU31180" /db_xref="EnsemblGenomes-Tr:CAB15096" /db_xref="GOA:O05264" /db_xref="InterPro:IPR009308" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG12387" /db_xref="UniProtKB/Swiss-Prot:O05264" /translation="MTIKANYDSAKQAYEKWGIDVEEALRQLEQVPISIHCWQGDDIE GFEVNKGELSGGIDVTGNYPGKAQTPEELRRDLEKALSLIPGKHRVNLHAIYAETNRE AVERDELKPQHFENWVKWAKNLGLGLDFNPTLFSHEKAADGLTLSHPDPDIREFWIRH CIACRRIGEYFGKELGTPCLTNIWIPDGYKDIPSDRLTPRKRLKESLDRIFSEEISEQ HNLDSIESKLFGLGSESYVVGSHEFYLAYALTNHKLCLLDTGHFHPTETVSNKISSML LYTDKLALHVSRPVRWDSDHVVVLDDELREIALEIVRNHALEKVAIGLDFFDASINRV AAWTIGTRNMIKALLYALLLPNGYLKQLQEEGRYTERLALMEEFKTYPFGAIWDSYCE QMGVPVKEAWLYDIKEYEQQVLLKRKASSPIV*" gene complement(3018440..3019714) /gene="rhaA" /locus_tag="BSU_31180" /old_locus_tag="BSU31180" downshifts complement(3018453) /Source="Nicolas_upshifts" /id="D1615" /incds=0 /nref=3 /ntot=29 /MaxReadThrough="0.802" /MaxDrop="4.45322" /score="14.0829844" /energy="-12.6" /TU="NA" /idTUdmin="U2421" /TUdmin=242 /isTUend="FALSE" CDS complement(3019740..3020054) /gene="rhaM" /locus_tag="BSU_31190" /old_locus_tag="BSU31190" /EC_number="5.1.3.32" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15576793, 15876375, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576793, 15876375, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-rhamnose mutarotase" /protein_id="NP_390997.1" /db_xref="EnsemblGenomes-Gn:BSU31190" /db_xref="EnsemblGenomes-Tr:CAB15097" /db_xref="GOA:O05263" /db_xref="InterPro:IPR008000" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR013448" /db_xref="SubtiList:BG12386" /db_xref="UniProtKB/Swiss-Prot:O05263" /translation="MKRKASIMFVHQDKYEEYKQRHDDIWPEMAEALKAHGAHHYSIF LDEETGRLFAYLEIEDEEKWRKMADTEVCQRWWKSMAPLMKTNSDFSPVAIDLKEVFY LD*" gene complement(3019740..3020054) /gene="rhaM" /locus_tag="BSU_31190" /old_locus_tag="BSU31190" CDS complement(3020072..3021529) /gene="rhaB" /locus_tag="BSU_31200" /old_locus_tag="BSU31200" /EC_number="2.7.1.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16674975, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16674975, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnulokinase" /protein_id="NP_390998.1" /db_xref="EnsemblGenomes-Gn:BSU31200" /db_xref="EnsemblGenomes-Tr:CAB15098" /db_xref="GOA:O05262" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR013449" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG12385" /db_xref="UniProtKB/Swiss-Prot:O05262" /translation="MIYTAIDVGASSGRIMVGELNEGKLDIQEIHRFANGFSQRDGHC LWDIDHLLKQILQGLQKVKTLGYEHCTVGIDTWAVDYVLLDEKGDRLREAISYRDRRT DHTIDKLEHTLSKAAIYQKTGIQFQPFNTIYQLFEEDRELLKKTDKIMMIPDYLGYCL TGKAVTEITNVSTTQLLNVSTGNLDPELLEAVSVLEQQFAPLTEPGCELGKLRNEWFP DYDLPACKVMTVATHDTASAVIAAPGVNDGWAYISSGTWSLIGVENKTPIITDLALEN NYTNERGANNTIRFLKNIIGMWVIQEVKQQLQADYSFQQLAEEAKKTEPFQQFINLND KRFLNPENMIKEIQHYCRQTRQKIPRTAGELACCIYSNLAIIYAIAIKELETITEKPI EQFHIIGGGARNDFLNQLTADMSGKAVYAGPIEATATGNLLMQMIAAKEVKDIKEARQ VVRNSFPIKVFTPKDIDRSTIIQSFQQTVLKALSK*" gene complement(3020072..3021529) /gene="rhaB" /locus_tag="BSU_31200" /old_locus_tag="BSU31200" CDS complement(3021534..3022310) /gene="rhaR" /locus_tag="BSU_31210" /old_locus_tag="BSU31210" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11496004, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11496004, 26712933; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the rhamnose operon(RhaR / l-rhamnulose-1-phosphate)" /protein_id="NP_390999.1" /db_xref="EnsemblGenomes-Gn:BSU31210" /db_xref="EnsemblGenomes-Tr:CAB15099" /db_xref="GOA:O05261" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12384" /db_xref="UniProtKB/Swiss-Prot:O05261" /translation="MLVAERQQKIVEIVNMRSSIRVSELSDIFSVTEETIRRDLEKLE KEHKLSRSHGGAVSIQQKESEIHFSEREITNVIEKKAIAHEAAKYVKSGDRIILDAST TAWYMAKILPDIELTVITNSMKAAIELSNKENISVISTGGILLEKSLSFAGPLAERSL ETYHVNKTFLSCKGFDVHNGMSDSNEWQALLKKRMIERSDQTILMADSSKWGNREFSH IASLQDVSRLITDSGLDPASVKALEDKKVKVTAVPLSKRG*" gene complement(3021534..3022310) /gene="rhaR" /locus_tag="BSU_31210" /old_locus_tag="BSU31210" misc_feature complement(3022344..3022363) /Source="Nicolas_upshift_promotors" /id="U2421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3189 /SigmaFactorBS="acgggctgcatgatcacggtagacggcggcgtccctgctgct tttacgcgttagataTATGCTATGATAAAAATATAagacggactacgatatgaggaag g" /listShort="yulB, yulC, yulD, yulE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3022360) /Source="Nicolas_upshifts" /id="U2421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3189 /SigmaFactorBS="acgggctgcatgatcacggtagacggcggcgtccctgctgct tttacgcgttagataTATGCTATGATAAAAATATAagacggactacgatatgaggaag g" /listShort="yulB, yulC, yulD, yulE" /GFF_Attribute="listLong" CDS complement(3022367..3024436) /gene="rhaE" /locus_tag="BSU_31220" /old_locus_tag="BSU31220" /EC_number="1.1.1.-" /EC_number="4.1.2.19" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:24391637, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24391637, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional rhamnulose-1-phosphate aldolase/alcohol dehydrogenase" /protein_id="NP_391000.1" /db_xref="EnsemblGenomes-Gn:BSU31220" /db_xref="EnsemblGenomes-Tr:CAB15100" /db_xref="GOA:P40747" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR013454" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG10947" /db_xref="UniProtKB/Swiss-Prot:P40747" /translation="MVKHIWDSERAAQLPKGVEELVYRSNLIGSDRTVCNWGGGNTSM KTTEKDFRGREIEVMWVKGSGSDLATMKAHNFSGLKLDDIRPLIKRDQMPDEEMVDYL SHCMIDSKHPRPSIETLLHAFLPYKHVDHTHPDAIISICCADNGKQIAEDIYGNRFVW VPYVRPGFTLSKMIAEGVANNPHAELVLMEKHGLVTWGETSETCYQKTISIIQEAEQY INDRINQHEVFGGKRYQPLPEDKRKQILAGIMPVIRGAVSEEKKMILSYDDHDDVLEF VNSVQAPALSQIGAACPDHLVHTKRVPLYIDWNPETQDVHKLADLIKSGVETFTSEYQ AYFTRNQQDGDQIFESAPRVILIPGIGMVNTGKSYAMSKVSGALYRRAIAVMKGATAL GQFVSLHENESYHVEYWPLELYKLTLAPPEAEFSRKVALITGGAGGIGSAACRRFAAE GGHVIVADLNIEGAQKIAGEINDAYGKGRAMAVKMDVTKEEDVQSAFERAALAYGGID IVVNNAGLATSSPFDETSLKEWNLNMNVLGTGYFLVAREAFKQMKHQNRGGSMVFVGS KNSVYAGKNASAYSSVKALETHLARCIAAEGGEFGIRVNSVLPDAVLQGSAIWGSSWR EERAAAYGIEPDQLEEHYRKRTALLVNIYPEDIAEAIAFFASSKAEKTTGCMITVDGG VPAAFTR*" gene complement(3022367..3024436) /gene="rhaE" /locus_tag="BSU_31220" /old_locus_tag="BSU31220" promotor_-10 complement(3024469..3024488) /Source="Nicolas_upshift_promotors" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3024481) /Source="Nicolas_upshifts" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" promotor_-35 complement(3024502..3024508) /Source="Nicolas_upshift_promotors" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3024574..3026562) /gene="tlpB" /locus_tag="BSU_31230" /old_locus_tag="BSU31230" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 10825179, 14563871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 10825179, 14563871; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391001.1" /db_xref="EnsemblGenomes-Gn:BSU31230" /db_xref="EnsemblGenomes-Tr:CAB15101" /db_xref="GOA:P39217" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10862" /db_xref="UniProtKB/Swiss-Prot:P39217" /translation="MGKFIQWIKQPSISKPLIAAFLAVLILPVGVLAYFSYQSAWNAL DRELISSAKGNVEELNSTLQNKLEDKVKAIDYYSETVDKDILLGKNKTLLKEKFKQYT TLNDDVGAIYAASEDKKLYKYPDSGVPKGFDPTGRDWYKQAVAEKGQAVFSEPYTDEA TGDIVVTISKQLKDGSGVIALDLNLDEVLTASKRIKIGKEGFAFITTGNKKYIAHPTI KPGTTGSGDWTNQVYSKKEGSFEYTFEGKEKKMAFTTNKLTGWKIAGTYFVSELQDAS SPVLNTAVIILCVSIVIGGILILYIIRAITKPLRKLVSTSAKISSGDLTEVIDIHSKN EFGQLGESFNEMSASLRSVIGVIQTSVENVASSSEELTASAAQTSKATEHITLAIEQF SDGNEAQSEKLETSSNHLSQMNEGISKVAQASSTITKSSIQSSEAAGSGEKLVEHTVG QMKTIDQSVQKAEAVVKGLETKSQDITSILNVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIEGLIQEIVREISTSLSMFQSVNHEVKEGLQITDQ TAESFKQIYEMTTQISGELQNLNATVEQLSAGSQEVSSAVEDISAVAKESSAGIQDIA ASAEEQLASMEEISSSAETLANMAEELQDITKKFKIES*" gene complement(3024574..3026562) /gene="tlpB" /locus_tag="BSU_31230" /old_locus_tag="BSU31230" downshifts complement(3024593) /Source="Nicolas_upshifts" /id="D1616" /incds=0 /nref=108 /ntot=174 /MaxReadThrough="3.32915" /MaxDrop="6.75141" /score="18.7221191" /energy="-8.3" /TU="NA" /idTUdmin="U2423" /TUdmin="-2" /isTUend="TRUE" promotor_-35 3026566..3026573 /Source="Nicolas_upshift_promotors" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3026583..3026601) /Source="Nicolas_upshift_promotors" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 3026589..3026608 /Source="Nicolas_upshift_promotors" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3026596) /Source="Nicolas_upshifts" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" upshifts 3026605 /Source="Nicolas_upshifts" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3026615..3026622) /Source="Nicolas_upshift_promotors" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3026671 /Source="Nicolas_upshifts" /id="D1617" /incds=0 /nref=4 /ntot=11 /MaxReadThrough="1.04089" /MaxDrop="4.2056" /score="13.4355481" /energy="-10.7" /TU="NA" /idTUdmin="U2424" /TUdmin=22 /isTUend="TRUE" CDS complement(3026676..3028661) /gene="mcpA" /locus_tag="BSU_31240" /old_locus_tag="BSU31240" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 9721285, 12011078" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 9721285, 12011078; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391002.2" /db_xref="EnsemblGenomes-Gn:BSU31240" /db_xref="EnsemblGenomes-Tr:CAB15102" /db_xref="GOA:P39214" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10861" /db_xref="UniProtKB/Swiss-Prot:P39214" /translation="MKKILQLIKQRSITRKLLVSFLSILIIPVVILAIFAYQSASSSL DRQMMGSALENVQQLNEIINTSIGEKENSADYFSEWLTKEKYNAKSNASIAEKFSQYI SINKDVESIYTSDTKGHFTRYPDLPMPSGYNPVERDWYKKAVANKGKVVITDPYKTAS TNTMVVTIAQQTKDGSGVIAINMTIENLLKTTKKVNIGTQGYAFIMTKDKKVVAHPNE QSGTELKGDWLDKMLSADKGDFQYTMDGDKKKMAFDTNKLTGWKIGGTMYLDEIHEAA QPVLHLALIVLAAAIIIGIIVMTLIIRSITTPLKQLVGSSKRISEGDLTETIDIRSKD ELGELGKSFNNMASSLRSLIHAIQDSVDNVAASSEELTASAAQTSKATEHITLAIEQF SNGNEKQNENIETAAEHIYQMNDGLTNMAQASEVITDSSVQSTEIASEGGKLVHQTVG QMNVIDKSVKEAEQVVRGLETKSKDITNILRVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIEGLIIEIVKEINTSLGMFQSVNQEVQTGLDITDK TEMSFKRISEMTNQIAGELQNMSATVQQLSASSEEVSGASEHIASISKESSAHIQDIA ASAEEQLASMEEISSSAETLSSMAEELRDMTKRFKIE*" gene complement(3026676..3028661) /gene="mcpA" /locus_tag="BSU_31240" /old_locus_tag="BSU31240" downshifts complement(3026681) /Source="Nicolas_upshifts" /id="D1618" /incds=0 /nref=196 /ntot=232 /MaxReadThrough="3.11319" /MaxDrop="7.54297" /score="40.6270404" /energy="-13.6" /TU="U2425" /idTUdmin="U2425" /TUdmin="-22" /isTUend="TRUE" promotor_-10 complement(3028682..3028700) /Source="Nicolas_upshift_promotors" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3028697) /Source="Nicolas_upshifts" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" S_feature complement(3028699..3028786) /Source="Nicolas_S_feature" /locus_tag="new_3208192_3208279_c" /HighExp="GM 150, T0.0H, T-1.40H, T-0.40H, MG 150, T-5.40H, T-3.40H, T-1.10H, T-2.40H, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1190" promotor_-35 complement(3028714..3028721) /Source="Nicolas_upshift_promotors" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3028787..3030775) /gene="tlpA" /locus_tag="BSU_31250" /old_locus_tag="BSU31250" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 10825179, 14563871, 26522943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 10825179, 14563871, 26522943; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein (membrane curvature dependent localisation)" /protein_id="NP_391003.1" /db_xref="EnsemblGenomes-Gn:BSU31250" /db_xref="EnsemblGenomes-Tr:CAB15103" /db_xref="GOA:P39216" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10860" /db_xref="UniProtKB/Swiss-Prot:P39216" /translation="MKKTLTTIRRSSIARRLIISFLLILIVPITALSVSAYQSAVASL DVQMTQSAKENVQILDHIIDDKISTTEKSLAYFSDWATAEKFQDKKKTELKQEFKQFI QMNDNVAAVFSSGKDGDFTRYPYADMPSDFNALERDWYKEAMANKGKTIVTEPYESIS SGKMVVTIARQTVDGSGVVAIDMKIDDLVTTAKGINIGKEGYAFILSQNKKVIAYSGE KAGTELKGDWVDKLYKDKSGDFEYTYKGKKKKMAFATSQTTGWKISGTMYANEIHDAA SRVLIMASIVLAIAIGAGMTAIYFVIRSITKPLRRIVASAEKISEGDLTETIEINSKD ELGVLSESFNHMAHSLRSLIHGIKDSVEHVASSSEELTASADQTSRATEHITMAIEQF SNGSESQSEKIETTTEQINEMNDGLAELARAAAVITETSADSTEVSSKGETLVQKTAG QMNTIDHSVKAAEQVVKGLEIKSKDITNILRVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIESLISEIVKEIHTSLNVLQSVNKEVETGLVMTDE TKQSFKHISQMTNQIASELQNMNATVEELSAGAQEISAASNDITAISKESSDGIQDIA ASAEEQLASMEEISSSALTLERMSEELRDLTKQFKVDK*" gene complement(3028787..3030775) /gene="tlpA" /locus_tag="BSU_31250" /old_locus_tag="BSU31250" promotor_-10 complement(3030800..3030818) /Source="Nicolas_upshift_promotors" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="promotor_-10" upshifts complement(3030815) /Source="Nicolas_upshifts" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" promotor_-35 complement(3030832..3030839) /Source="Nicolas_upshift_promotors" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="promotor_-35" CDS complement(3030952..3032940) /gene="mcpB" /locus_tag="BSU_31260" /old_locus_tag="BSU31260" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:12011078, 14731274, 15317802, 15544802, 19901023, 20864474, 22931217, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12011078, 14731274, 15317802, 15544802, 19901023, 20864474, 22931217, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391004.2" /db_xref="EnsemblGenomes-Gn:BSU31260" /db_xref="EnsemblGenomes-Tr:CAB15104" /db_xref="GOA:P39215" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10859" /db_xref="UniProtKB/Swiss-Prot:P39215" /translation="MKTFINWLKKPSISKKLIVSFIAILIIPILILEFSSYRSASGKL DQEIMGNAKNSVDTFNTTVTNDLGEKAKAVTFFSESLKRSAFKGKSNQEEIKAKFSQY VSINQGVARIYGGADNGTYVQAPKEKLPEGYDPRQRPWYQDAMKAGGEIVVTDPYVAA SDGSMVITIAQELKDGSGVVAMDITIDKLLEQMKQIKVGKEGYAFIATKNKTYVAHKN HKAGEKLSGDWVAKMYANDSGELQYTLNNEDKKMTYTTNELTGWKIAGTMYMDEIKDA SKSVLTTGMIVLIASIVAGGILILFIVRSITKPLKRLVQSSKTISRGDLTETIEIHSK DELGELGESFNEMGQSLRSLISAIQDSVNNVAASSEQLTASAGQTSKATEHITMAIEQ FSNGNEEQSEKVESSSHQLNLMNEGLQQVSQTSSDITKASIQSTEIAGTGEKFVQQTV GQMNSINQSVQQAEAVVKGLEGKSKDITSILRVINGIADQTNLLALNAAIEAARAGES GRGFSVVAEEVRKLAVQSADSAKEIEKLIQEIVAEIDTSLHMFKEVNQEVQSGLVVTD NTKESFQSIFSMTNEIAGKLQTMNSTVEQLSDRSQHVSAAVSGIADVSKESSASIQDI AASAEEQLASMEEISSSATTLAQMAEELRDLTKQFKIE*" gene complement(3030952..3032940) /gene="mcpB" /locus_tag="BSU_31260" /old_locus_tag="BSU31260" downshifts complement(3030971) /Source="Nicolas_upshifts" /id="D1619" /incds=0 /nref=136 /ntot=224 /MaxReadThrough="3.76161" /MaxDrop="7.09773" /score="30.8363643" /energy="-10.7" /TU="U2427" /idTUdmin="U2427" /TUdmin="-132" /isTUend="FALSE" promotor_-10 complement(3032961..3032979) /Source="Nicolas_upshift_promotors" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3032982) /Source="Nicolas_upshifts" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" promotor_-35 complement(3032992..3032999) /Source="Nicolas_upshift_promotors" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3033042..3033051 /Source="Nicolas_upshift_promotors" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3033065..3033084 /Source="Nicolas_upshift_promotors" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3033068 /Source="Nicolas_upshifts" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" CDS 3033098..3033835 /gene="tgl" /locus_tag="BSU_31270" /old_locus_tag="BSU31270" /EC_number="2.3.2.13" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9692191, 16267299, 16751597, 16936016, 18249137, 26322858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9692191, 16267299, 16751597, 16936016, 18249137, 26322858; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein-glutamine gamma-glutamyltransferase (transglutaminase)" /protein_id="NP_391005.1" /db_xref="EnsemblGenomes-Gn:BSU31270" /db_xref="EnsemblGenomes-Tr:CAB15105" /db_xref="GOA:P40746" /db_xref="InterPro:IPR020916" /db_xref="PDB:4P8I" /db_xref="PDB:4PA5" /db_xref="SubtiList:BG10946" /db_xref="UniProtKB/Swiss-Prot:P40746" /translation="MIIVSGQLLRPQDIENWQIDQDLNPLLKEMIETPVQFDYHSIAE LMFELKLRMNIVAAAKTLHKSGAKFATFLKTYGNTTYWRVSPEGALELKYRMPPSKAI RDIAENGPFYAFECATAIVIIYYLALIDTIGEDKFNASFDRIILYDWHYEKLPIYTET GHHFFLGDCLYFKNPEFDPQKAQWRGENVILLGEDKYFAHGLGILNGKQIIDKLNSFR KKGALQSAYLLSQATRLDVPSLFRIVR*" gene 3033098..3033835 /gene="tgl" /locus_tag="BSU_31270" /old_locus_tag="BSU31270" promotor_-10 complement(3033123..3033142) /Source="Nicolas_upshift_promotors" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="promotor_-10" upshifts complement(3033131) /Source="Nicolas_upshifts" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" promotor_-35 complement(3033158..3033162) /Source="Nicolas_upshift_promotors" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="promotor_-35" S_feature 3033836..3036656 /Source="Nicolas_S_feature" /locus_tag="new_3213329_3216149" /HighExp="S6, S8, S7, BT, S5, C30, B36, Pyr, BC, C90" /AntisenseName="yugT" /AntisenseCor="0.63350809138227804" /AntisenseRegPval="-30.9" /CDS_PredictionProba="0.61985900000000005" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1191" CDS complement(3033849..3034103) /gene="yuzH" /locus_tag="BSU_31279" /old_locus_tag="BSU31279" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097776.1" /db_xref="EnsemblGenomes-Gn:BSU31279" /db_xref="EnsemblGenomes-Tr:CAX52682" /db_xref="UniProtKB/Swiss-Prot:C0H3Q3" /translation="MNILQYSYKKRGKIEFVFEGWPHSKVTMVPIKGYYFVRFIKWSS QDPIVTRNDLEKMEWAANQYFGTAPFYRKRKAFETPSSGK*" gene complement(3033849..3034103) /gene="yuzH" /locus_tag="BSU_31279" /old_locus_tag="BSU31279" downshifts complement(3033875) /Source="Nicolas_upshifts" /id="D1620" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="2.39206" /MaxDrop="2.92958" /score="-2.51333596" /energy="-14.7" /TU="NA" /idTUdmin="U2430" /TUdmin=0 /isTUend="TRUE" S_feature complement(3034104..3034360) /Source="Nicolas_S_feature" /locus_tag="new_3213597_3213853_c" /HighExp="Etha, Sw, Salt, Gly, BC, M9-stat, Lbstat, Heat, LPhT, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37980700000000001" /TUshortSig="SigB" /TUshortPSig="0.969" /TUlongSig="NA" /TUlongPSig="NA" /label="S1192" CDS complement(3034361..3034759) /gene="yugU" /locus_tag="BSU_31280" /old_locus_tag="BSU31280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391006.2" /db_xref="EnsemblGenomes-Gn:BSU31280" /db_xref="EnsemblGenomes-Tr:CAB15106" /db_xref="InterPro:IPR001602" /db_xref="InterPro:IPR035917" /db_xref="SubtiList:BG12373" /db_xref="UniProtKB/Swiss-Prot:O05243" /translation="MLKTLQIKTTKRDEMIDITREVEAFLQETGITSGAALIYCPHTT AGITINENADPDVKKDMLRRFDEVYPWEHELDRHMEGNTAAHMKSSTVGASQHVIVEN GRLILGTWQGIYFCEFDGPRTRTCYIKMMG*" gene complement(3034361..3034759) /gene="yugU" /locus_tag="BSU_31280" /old_locus_tag="BSU31280" CDS complement(3034719..3034853) /locus_tag="BSU_31289" /old_locus_tag="BSU31289" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514000.1" /translation="MFYRVYESGLTGKKRTQNELSDESGQTKGETNAENTANQNNQTR *" gene complement(3034719..3034853) /locus_tag="BSU_31289" /old_locus_tag="BSU31289" promotor_-10 complement(3034802..3034821) /Source="Nicolas_upshift_promotors" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3034809) /Source="Nicolas_upshifts" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" promotor_-35 complement(3034836..3034842) /Source="Nicolas_upshift_promotors" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3034879..3036543) /gene="yugT" /locus_tag="BSU_31290" /old_locus_tag="BSU31290" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1761534; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oligo-1,6-glucosidase" /protein_id="NP_391007.2" /db_xref="EnsemblGenomes-Gn:BSU31290" /db_xref="EnsemblGenomes-Tr:CAB15118" /db_xref="GOA:O05242" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="SubtiList:BG12372" /db_xref="UniProtKB/Swiss-Prot:O05242" /translation="MKKAWWKEAVVYQIYPRSFKDSNGDGIGDIQGIRTKLSYIKELG ADVIWICPLYDSPNADNGYDIRDYQNILSEFGTMEDFDELLGDIHDLDMKLIMDLVVN HTSDEHPWFIESRSSIHSEKRDWYIWKDGKNGKTPNNWESIFGGPAWEYDQKTSQYYL HLFDKKQPDLNWENEKVRNAVYDMINWWLDKGIDGFRVDAITHIKKKEGFPDMPNPKG LDYVPSFPYHMNADGIMDLLTELKENTFSRYPIMTVGEANGVAAKEAADWAGEKNGIF SMIFQFEHLGLWDVEINESIDIVAFKRILTDWQDSLEGIGWNALFMENHDQPRSVSVW GDDGVYLKESAKALSAVYFLMKGTPFIYQGQELGMTNVAFPSIEDYDDVALKRLYETK TAKGTSHEDVMKIVWKKGRDNSRTPMQWNAGPYAGFSEAKPWIGINENYKWLNAEAQK NDKTSVYHFYKSLIKLRQTYDVFINGTYELILPEDQQIFAYLRKNESHTALIAANLTG TPALFRHSGLPLSSDALVLSNIETEPHKHMTSVLLKPYEARIYLWC*" gene complement(3034879..3036543) /gene="yugT" /locus_tag="BSU_31290" /old_locus_tag="BSU31290" downshifts complement(3034895) /Source="Nicolas_upshifts" /id="D1621" /incds=0 /nref=13 /ntot=38 /MaxReadThrough="1.79723" /MaxDrop="4.64379" /score="19.4176812" /energy="-6.5" /TU="NA" /idTUdmin="U2432" /TUdmin="-7" /isTUend="TRUE" promotor_-10 complement(3035851..3035870) /Source="Nicolas_upshift_promotors" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3035856) /Source="Nicolas_upshifts" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3035884..3035891) /Source="Nicolas_upshift_promotors" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3036568..3036586) /Source="Nicolas_upshift_promotors" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3036585) /Source="Nicolas_upshifts" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" promotor_-35 complement(3036602..3036607) /Source="Nicolas_upshift_promotors" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3036670..3037959) /gene="yugS" /locus_tag="BSU_31300" /old_locus_tag="BSU31300" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_391008.2" /db_xref="EnsemblGenomes-Gn:BSU31300" /db_xref="EnsemblGenomes-Tr:CAB15119" /db_xref="GOA:O05241" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12371" /db_xref="UniProtKB/Swiss-Prot:O05241" /translation="MLILQLIAIFVLIGITAVFVAAEFAIVKIRGSKINQLIESGDSR ALAAHKIISNLDEYLSACQLGITITALGLGWLGEPTFERFLHPLFTMTGIPEPFNHIV TFVVAFIIVTFLHVVMGELAPKTVSIQKAEAVSLWIAKPLIWFYKITYPFIKALNGSA SFLVKLFGFHSVKEHQVVISEEELRLILSESYEKGEINQSEFRYVNKIFEFDNRVARE IMIPRTEIAVISLEQSLEEAIHHIINERYTRYPVIKDDKDHILGIINSKDMFKAYFLG QPIKLNQIMRPVIRVIESIPVQQLLIRMQKERIHMAILVDEYGGTAGLVTVEDIIEEI VGEIRDEYDQDETPHILKKGEHHYVMDGKALIDEVNDLLDIAIENEEIDTIAGWLLTQ KMELKAGDVIHAEGCEFKILDAEDHHIRFVEIKKTDF*" gene complement(3036670..3037959) /gene="yugS" /locus_tag="BSU_31300" /old_locus_tag="BSU31300" downshifts complement(3036679) /Source="Nicolas_upshifts" /id="D1622" /incds=0 /nref=5 /ntot=28 /MaxReadThrough="0.89237" /MaxDrop="3.67001" /score="3.60520478" /energy="-7.6" /TU="NA" /idTUdmin="U2434" /TUdmin=13 /isTUend="TRUE" promotor_-35 3037488..3037494 /Source="Nicolas_upshift_promotors" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3037508..3037526 /Source="Nicolas_upshift_promotors" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3037514 /Source="Nicolas_upshifts" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" S_feature 3037518..3038170 /Source="Nicolas_S_feature" /locus_tag="new_3217011_3217663" /HighExp="Etha, Sw, Gly, Salt, BC, B60, Heat, S8, B36, HiTm" /AntisenseName="yugS" /AntisenseCor="0.12310225183111501" /AntisenseRegPval="-1.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1193" CDS complement(3038003..3038680) /gene="yugP" /locus_tag="BSU_31310" /old_locus_tag="BSU31310" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16704729, 16850406, 24383880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent protease/peptidase" /protein_id="NP_391009.1" /db_xref="EnsemblGenomes-Gn:BSU31310" /db_xref="EnsemblGenomes-Tr:CAB15120" /db_xref="GOA:O05248" /db_xref="InterPro:IPR007395" /db_xref="SubtiList:BG12370" /db_xref="UniProtKB/Swiss-Prot:O05248" /translation="MLFIFLTIAALGLSFWAQFKVKSNFEKYSKVEASSGRTGAETAR RILDINGLYDVPVEPVRGTLTDHYDPTRRVVRLSEPVYYGRSISAISVASHEVGHALQ HQESYGALVLRHKIFPVVNFASGVAPLLFLGGMLLGSLNLIGLGIILFSAAVFFQLIT LPVEFNASSRAKQIIVSEGFIRNNEENGVNKVLSAAALTYVAAALVSLFELLRFVMIF LNGRDEN*" gene complement(3038003..3038680) /gene="yugP" /locus_tag="BSU_31310" /old_locus_tag="BSU31310" downshifts complement(3038013) /Source="Nicolas_upshifts" /id="D1623" /incds=0 /nref=153 /ntot=249 /MaxReadThrough="3.51629" /MaxDrop="4.854" /score="33.0420688" /energy="-13" /TU="U2434,U2435" /idTUdmin="U2435" /TUdmin="-243" /isTUend="FALSE" S_feature 3038355..3039031 /Source="Nicolas_S_feature" /locus_tag="new_3217848_3218524" /HighExp="Sw, S8, Salt, BC, S7, Etha, Gly, B36, B60, LPhT" /AntisenseName="yuzI" /AntisenseCor="0.20035821815170399" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1194" promotor_-10 complement(3038715..3038734) /Source="Nicolas_upshift_promotors" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3038722..3038985) /gene="yuzI" /locus_tag="BSU_31319" /old_locus_tag="BSU31319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16704729; Product type f : factor" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097777.1" /db_xref="EnsemblGenomes-Gn:BSU31319" /db_xref="EnsemblGenomes-Tr:CAX52683" /db_xref="GOA:C0H3Q4" /db_xref="UniProtKB/Swiss-Prot:C0H3Q4" /translation="MTIFQRTIVVLIGTQLAASAVILFIFDLNSYNHFSGSFSWLHFL KELAGSFAFYLFSAGLFFLLIGLCAPSRKKKRISVHEKENSLK*" gene complement(3038722..3038985) /gene="yuzI" /locus_tag="BSU_31319" /old_locus_tag="BSU31319" upshifts complement(3038736) /Source="Nicolas_upshifts" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" promotor_-35 complement(3038748..3038755) /Source="Nicolas_upshift_promotors" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3038997..3039015) /Source="Nicolas_upshift_promotors" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3039011) /Source="Nicolas_upshifts" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" promotor_-35 complement(3039031..3039036) /Source="Nicolas_upshift_promotors" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3039032..3039364 /gene="mstX" /locus_tag="BSU_31321" /old_locus_tag="BSU31321" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15731457, 23737939, 25297828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15731457, 23737939, 25297828; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="atypical membrane-integrating regulator of biofilm formation (Mistic protein)" /protein_id="YP_003097778.1" /db_xref="EnsemblGenomes-Gn:BSU31321" /db_xref="EnsemblGenomes-Tr:CAX52684" /db_xref="GOA:Q5BU39" /db_xref="InterPro:IPR021078" /db_xref="PDB:1YGM" /db_xref="UniProtKB/Swiss-Prot:Q5BU39" /translation="MFCTFFEKHHRKWDILLEKSTGVMEAMKVTSEEKEQLSTAIDRM NEGLDAFIQLYNESEIDEPLIQLDDDTAELMKQARDMYGQEKLNEKLNTIIKQILSIS VSEEGEKE*" gene 3039032..3039364 /gene="mstX" /locus_tag="BSU_31321" /old_locus_tag="BSU31321" promotor_-35 3039049..3039055 /Source="Nicolas_upshift_promotors" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3039070..3039087 /Source="Nicolas_upshift_promotors" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3039081 /Source="Nicolas_upshifts" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" CDS 3039361..3040347 /gene="kbfO" /locus_tag="BSU_31322" /old_locus_tag="BSU31322" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16704729, 23737939, 25297828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16704729, 23737939, 25297828; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium channel protein involved in biofilm formation" /protein_id="NP_391010.3" /db_xref="EnsemblGenomes-Gn:BSU31322" /db_xref="EnsemblGenomes-Tr:CAB15121" /db_xref="GOA:Q795M8" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR013099" /db_xref="InterPro:IPR028325" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12369" /db_xref="UniProtKB/Swiss-Prot:Q795M8" /translation="MKSNRIFISWLRWPLFIRIGVIILCLILLFGQIIYILEPKQFTS VFEGIWWAVVTVSTVGYGDYVPHTPLGQAAGILLILSGASFVTAYFATLSAAAFSRQH RYIEGKVAYKGRDHIILIGWNEKTNRLLKDLQLAAPSKTVVLIDESLTEGPLIENVHF IRGHAADDGTLKRANITEAESVMITADQYKSETDADMLSVLTLLSVKGLNPLAYCIVE ILTDRFVTNAERAGANQIIGTSEFISRAMLQHYQVKLRPSKQQNGIKLTLDQHVELLA VPDELKGAAYKTCVLYFLDHNTTIIGIQKKEGPMLSPPLTYKVLETDQFLAI*" gene 3039361..3040347 /gene="kbfO" /locus_tag="BSU_31322" /old_locus_tag="BSU31322" downshifts complement(3040322) /Source="Nicolas_upshifts" /id="D1624" /incds=0 /nref=44 /ntot=128 /MaxReadThrough="0.617940000000001" /MaxDrop="4.76695" /score="21.5904825" /energy="-11.3" /TU="NA" /idTUdmin="U2437" /TUdmin=0 /isTUend="TRUE" CDS complement(3040344..3040748) /gene="yugN" /locus_tag="BSU_31330" /old_locus_tag="BSU31330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391011.1" /db_xref="EnsemblGenomes-Gn:BSU31330" /db_xref="EnsemblGenomes-Tr:CAB15122" /db_xref="InterPro:IPR014967" /db_xref="InterPro:IPR036491" /db_xref="SubtiList:BG12368" /db_xref="UniProtKB/Swiss-Prot:O05246" /translation="MIPIPSAIDGQSFLLQELEQVMKPLGYVINGGWEYDHGYFDYKI DDRDGYLFLRIPVNAVQGSLDERGAAVRIGTPFMLRQVFQADVDDHAEGGPFQSLFNQ FSEPERRDAEIDPAFLDIGASLVKELEDVLLH*" gene complement(3040344..3040748) /gene="yugN" /locus_tag="BSU_31330" /old_locus_tag="BSU31330" S_feature complement(3040749..3040807) /Source="Nicolas_S_feature" /locus_tag="new_3220242_3220300_c" /HighExp="M0t90, M40t90, S6, S8, S7, T0.30H, Lbstat, M9-stat, T1.30H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, Sig-, SigA" /TUshortPSig="0.686, 0.141, 0.984" /TUlongSig="SigA" /TUlongPSig="0.988" /label="S1195" CDS complement(3040808..3041179) /gene="yugM" /locus_tag="BSU_31340" /old_locus_tag="BSU31340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391012.1" /db_xref="EnsemblGenomes-Gn:BSU31340" /db_xref="EnsemblGenomes-Tr:CAB15123" /db_xref="GOA:O05245" /db_xref="SubtiList:BG12367" /db_xref="UniProtKB/Swiss-Prot:O05245" /translation="MFMKQLVKHLIIAGFSAAILSFLISFDAVYTGFSSSFGGTLSHF FIHSFLLIGLPLALFTDAVHRILHLKRTHTLFTKLGLYATVVYVSWDSAVWLAAAMAV YFLIECAFFPVGRAKETTISM*" gene complement(3040808..3041179) /gene="yugM" /locus_tag="BSU_31340" /old_locus_tag="BSU31340" CDS complement(3041238..3042590) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" /EC_number="5.3.1.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4214896, 4275311, 11489127, 19052382, 21453533, 22720735, 24705866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate isomerase" /protein_id="NP_391013.2" /db_xref="EnsemblGenomes-Gn:BSU31350" /db_xref="EnsemblGenomes-Tr:CAB15124" /db_xref="GOA:P80860" /db_xref="InterPro:IPR001672" /db_xref="InterPro:IPR018189" /db_xref="InterPro:IPR035476" /db_xref="InterPro:IPR035482" /db_xref="SubtiList:BG12366" /db_xref="UniProtKB/Swiss-Prot:P80860" /translation="MTHVRFDYSKALTFFNEHELTYLRDFVKTAHHNIHEKTGAGSDF LGWVDLPEHYDKEEFARIKKSAEKIKSDSDVLLVVGIGGSYLGARAAIEALNHAFYNT LPKAKRGNPQVIFIGNNISSSYMRDVMDLLEDVDFSINVISKSGTTTEPAIAFRIFRK LLEEKYGKEEAKARIYATTDKERGALKTLSNEEGFESFVIPDDVGGRYSVLTAVGLLP IAVSGVNIDDMMKGALDASKDFATSELEDNPAYQYAVVRNVLYNKGKTIEMLINYEPA LQYFAEWWKQLFGESEGKDEKGIYPSSANYSTDLHSLGQYVQEGRRDLFETVLNVEKP KHELTIEEADNDLDGLNYLAGKTVDFVNKKAFQGTMLAHTDGNVPNLIVNIPELNAYT FGYLVYFFEKACAMSGYLLGVNPFDQPGVEAYKVNMFALLGKPGFEEKKAELEKRLED *" gene complement(3041238..3042590) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" downshifts complement(3041249) /Source="Nicolas_upshifts" /id="D1625" /incds=0 /nref=90 /ntot=198 /MaxReadThrough="6.86736" /MaxDrop="4.4585" /score="24.139293" /energy="-16.8" /TU="U2437,U2438,U2439" /idTUdmin="U2441" /TUdmin=19 /isTUend="TRUE" promotor_-10 complement(3041405..3041423) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3041422) /Source="Nicolas_upshifts" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" promotor_-35 complement(3041439..3041444) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3042563) /Source="Nicolas_upshifts" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" misc_feature complement(3042566..3042577) /Source="Nicolas_upshift_promotors" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3042622..3042641) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3042628) /Source="Nicolas_upshifts" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" S_feature complement(3042630..3042701) /Source="Nicolas_S_feature" /locus_tag="new_3222123_3222194_c" /HighExp="Etha, H2O2, Paraq, Oxctl, G180, G150, dia5, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.988" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1196" promotor_-35 complement(3042656..3042659) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3042702..3043874) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 1809209, 2673038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase subunit" /protein_id="NP_391014.1" /db_xref="EnsemblGenomes-Gn:BSU31360" /db_xref="EnsemblGenomes-Tr:CAB15125" /db_xref="GOA:O05240" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12365" /db_xref="UniProtKB/Swiss-Prot:O05240" /translation="MENFTYYNPTKLIFGKGQLEQLRKEFKRYGKNVLLVYGGGSIKR NGLYDQVTGILKEEGAVVHELSGVEPNPRLATVEKGIGLCREHDIDFLLAVGGGSVID CTKAIAAGVKYDGDAWDIFSKKVTAEDALPFGTVLTLAATGSEMNPDSVITNWETNEK FVWGSNVTHPRFSILDPENTFTVPENQTVYGMVDMMSHVFEQYFHNVENTPLQDRMCF AVLQTVIETAPKLLEDLENYELRETILYAGTIALNGTLQMGYFGDWASHTMEHAVSAV YDIPHAGGLAILFPNWMRYTLDTNVGRFKNLMLNMFDIDTEGKTDKEIALEGIDKLSA FWTSLGAPSRLADYNIGEEKLELIADIAAKEMEHGGFGNFQKLNKDDVLAILRASL*" gene complement(3042702..3043874) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" S_feature 3043037..3043958 /Source="Nicolas_S_feature" /locus_tag="new_3222530_3223451" /HighExp="S6, S7, S8, BT, S5, C30, LBGstat, B36, G135, G150" /AntisenseName="yugK" /AntisenseCor="4.31382473780575E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1197" promotor_-10 complement(3043907..3043926) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-10" upshifts complement(3043920) /Source="Nicolas_upshifts" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" promotor_-35 complement(3043943..3043946) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-35" CDS complement(3043978..3045141) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 2673038, 9643546, 11466286, 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase" /protein_id="NP_391015.1" /db_xref="EnsemblGenomes-Gn:BSU31370" /db_xref="EnsemblGenomes-Tr:CAB15126" /db_xref="GOA:O05239" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12364" /db_xref="UniProtKB/Swiss-Prot:O05239" /translation="MQNFTYWNPTKLIFGRGEVERLPEELKPYGKNVLLVYGGGSIKR SGLYDQVIEQLNKAGATVHELAGVEPNPRVSTVNKGVAICKEQNIDFLLAVGGGSVID CTKAIAAGAKYDGDAWDIVTKKHQPKDALPFGTVLTLAATGSEMNSGSVITNWETKEK YGWGSPLVFPKFSILDPVNTFTVPKNHTIYGMVDMMSHVFEQYFHHVSNTPYQDRMCE SLLRTVIETAPKLINDLENYELRETILYTGTIALNGMLSMGARGDWATHNIEHAVSAV YDIPHAGGLAILFPNWMRHTLSENPARMKQLAVRVFDVEEAGKTDEEIALEGIDKLSA FWTSLGAPNRLADYDINDEQLDTIADKAMANGTFGQFKSLNKEDVLSILKASL*" gene complement(3043978..3045141) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" downshifts complement(3043993) /Source="Nicolas_upshifts" /id="D1626" /incds=0 /nref=167 /ntot=237 /MaxReadThrough="6.69366" /MaxDrop="4.74696" /score="28.8200012" /energy="-13.4" /TU="U2441" /idTUdmin="U2444" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3045156..3045175) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-10" upshifts complement(3045174) /Source="Nicolas_upshifts" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" S_feature complement(3045176..3045331) /Source="Nicolas_S_feature" /locus_tag="new_3224669_3224824_c" /HighExp="S8, S7, S4, S5, S6, LoTm, Cold, LBGtran, G180, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25658199999999998" /TUshortSig="SigGF, SigA" /TUshortPSig="0.679, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1198" promotor_-35 complement(3045190..3045197) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-35" promotor_-35 3045227..3045233 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3045248..3045266 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3045258 /Source="Nicolas_upshifts" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" S_feature 3045259..3045317 /Source="Nicolas_S_feature" /locus_tag="new_3224752_3224810" /HighExp="Etha, Salt, Heat, M9-stat, LPhT, Sw, Gly, BC, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1199" promotor_-35 3045304..3045310 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3045306..3045317) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3045319 /Source="Nicolas_upshifts" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" promotor_-10 3045324..3045335 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3045331..3045337) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3045331) /Source="Nicolas_upshifts" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" S_feature complement(3045333..3045644) /Source="Nicolas_S_feature" /locus_tag="new_3224826_3225137_c" /HighExp="Cold, LBGtran, LoTm, G180, LBGexp, dia15, G135, H2O2, Paraq, Oxctl" /AntisenseName="yuzA" /AntisenseCor="-0.50065532030853999" /AntisenseRegPval="-17.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1200" CDS 3045371..3045607 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391016.1" /db_xref="EnsemblGenomes-Gn:BSU31380" /db_xref="EnsemblGenomes-Tr:CAB15127" /db_xref="GOA:O32087" /db_xref="InterPro:IPR007211" /db_xref="SubtiList:BG14050" /db_xref="UniProtKB/Swiss-Prot:O32087" /translation="MSTIQRICLVLTIIGAINWGLIGFFQFDLVAAIFGGQGSALSRI IYGLVGIAGLINLGLLFKPNEERSREEAANPEMR*" gene 3045371..3045607 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" downshifts 3045567 /Source="Nicolas_upshifts" /id="D1627" /incds=0 /nref=3 /ntot=45 /MaxReadThrough="7.39676" /MaxDrop="2.87922" /score="13.9936296" /energy="-12" /TU="U2442,U2443" /idTUdmin="U2442" /TUdmin="-66" /isTUend="FALSE" downshifts 3045633 /Source="Nicolas_upshifts" /id="D1628" /incds=0 /nref=25 /ntot=56 /MaxReadThrough="1.29261" /MaxDrop="7.50276" /score="13.9936296" /energy="-12" /TU="NA" /idTUdmin="U2442" /TUdmin=0 /isTUend="TRUE" CDS complement(3045685..3046077) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 16014871, 19152054, 19636895; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; putative phosphorylase or nucleotidyl transferase; general stress protein" /protein_id="NP_391017.1" /db_xref="EnsemblGenomes-Gn:BSU31390" /db_xref="EnsemblGenomes-Tr:CAB15128" /db_xref="GOA:P80870" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="PDB:2K4K" /db_xref="SubtiList:BG12363" /db_xref="UniProtKB/Swiss-Prot:P80870" /translation="MAAKFEVGSVYTGKVTGLQAYGAFVALDEETQGLVHISEVTHGF VKDINEHLSVGDEVQVKVLAVDEEKGKISLSIRATQAAPEKKESKPRKPKAAQVSEEA STPQGFNTLKDKLEEWIEMSNRKDLIKK*" gene complement(3045685..3046077) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" downshifts complement(3045689) /Source="Nicolas_upshifts" /id="D1629" /incds=0 /nref=232 /ntot=268 /MaxReadThrough="5.9665" /MaxDrop="6.0195" /score="13.5952751" /energy="-15.6" /TU="U2445" /idTUdmin="U2448" /TUdmin="-2" /isTUend="TRUE" promotor_-10 complement(3046119..3046138) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-10" upshifts complement(3046126) /Source="Nicolas_upshifts" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" S_feature complement(3046128..3046278) /Source="Nicolas_S_feature" /locus_tag="new_3225621_3225771_c" /HighExp="G180, C30, G135, LBGexp, G150, Oxctl, HPh, Cold, BMM, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1201" promotor_-35 complement(3046154..3046158) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-35" promotor_-35 3046181..3046187 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3046194..3047178 /Source="Nicolas_S_feature" /locus_tag="new_3225687_3226671" /HighExp="LoTm, C30, Salt, S7, S5, S8, Sw, S3, C90, S6" /AntisenseName="yugH" /AntisenseCor="-0.45629591209076698" /AntisenseRegPval="-14.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.662" /TUlongSig="NA" /TUlongPSig="NA" /label="S1202" upshifts 3046194 /Source="Nicolas_upshifts" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" promotor_-10 3046202..3046220 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3046279..3047439) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" /EC_number="2.6.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_391018.2" /db_xref="EnsemblGenomes-Gn:BSU31400" /db_xref="EnsemblGenomes-Tr:CAB15129" /db_xref="GOA:Q795M6" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12362" /db_xref="UniProtKB/Swiss-Prot:Q795M6" /translation="MTSYLSDYVQQIKPSGIRKFFDLAATMEGVISLGVGEPDFVTAW NVREASILSLEQGYTSYTANAGLYSLREEISRYLSNRFDLSYSPDNELIVTVGASQAL DIAIRAIVNPGEEVIIPEPCFVAYDALVSLAGGIPVHVHTTADKGFKATAADFEAAVT EKTKAILICSPSNPTGSVYSKEELNEIAEFAKKHDVIVLADEIYAELTYDEEFTSIAA LPGMKERTVVISGFSKAFAMTGWRLGFAAAPSLLRDAMLKIHQYAMMCAPAMAQFAAL EGLKNGMEDVEKMKKSYRRRRNLFVESLNEIGLSCHHPGGAFYAFPSIKSMGMSSEQF AEELLTQEKVAVVPGSVFGPSGEGYIRCSYATSIEQLQEALVRMKRFLHKTT*" gene complement(3046279..3047439) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" promotor_-35 3047331..3047337 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3047349 /Source="Nicolas_upshifts" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 3047351..3047355 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3047440..3047940) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_391019.1" /db_xref="EnsemblGenomes-Gn:BSU31410" /db_xref="EnsemblGenomes-Tr:CAB15130" /db_xref="GOA:O05236" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12361" /db_xref="UniProtKB/Swiss-Prot:O05236" /translation="MKLTEKETEILEILDENSRADLETIAKMAGIPVNEVKTIIDKLE KEKVIIDYSAMIDWRKVDGHEGVTAMIDVKVTPKRGVGFDEVAERIYRFQEVESVYLM SGVYDLSVVIRGNSMSDVARFVSDKLSTLDSVVSTTTHFILKKYKHDGKVFETGDDDK RIVVSP*" gene complement(3047440..3047940) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" promotor_-10 complement(3047970..3047989) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-10" promotor_-35 3047976..3047982 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3047991) /Source="Nicolas_upshifts" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" promotor_-10 3047997..3048008 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3047997 /Source="Nicolas_upshifts" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" promotor_-35 complement(3048000..3048007) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-35" S_feature 3048009..3048087 /Source="Nicolas_S_feature" /locus_tag="new_3227502_3227580" /HighExp="S8, S5, S6, S7, S4, C30, Glucon, Pyr, nit, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1203" CDS 3048088..3048909 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391020.1" /db_xref="EnsemblGenomes-Gn:BSU31420" /db_xref="EnsemblGenomes-Tr:CAB15131" /db_xref="GOA:O05235" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR013595" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12360" /db_xref="UniProtKB/Swiss-Prot:O05235" /translation="MEAVSPIRRFTVDGVNVYYEHYQNPGRQTLVCVHGFLSSAFSFR KVIPLLRDKYDIIALDLPPFGQSEKSRTFIYTYQNLAKLVIGILEHLQVKQAVLVGHS MGGQISLSAALQKPELFSKVVLLCSSGYLKRSHPTIIFGTHIPYFHLYIKRWLSKEGV MKNLLNVVHDKSLIDEEMIDGYGRPFQDEQIFKAMTRFIRHREGDLEPEQLKKMNKPA LLIWGEEDRIVPMEIGKRLHADLPNSVLYSLGQTGHLVPEERPELISEHIADFIK*" gene 3048088..3048909 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" downshifts 3048889 /Source="Nicolas_upshifts" /id="D1630" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="1.0929" /MaxDrop="3.08755" /score="11.2614618" /energy="-6.6" /TU="NA" /idTUdmin="U2449" /TUdmin=0 /isTUend="TRUE" downshifts complement(3048936) /Source="Nicolas_upshifts" /id="D1631" /incds=0 /nref=20 /ntot=156 /MaxReadThrough="2.22671" /MaxDrop="4.10906" /score="25.9859375" /energy="-6.6" /TU="NA" /idTUdmin="U2451" /TUdmin=7 /isTUend="TRUE" CDS complement(3048938..3049198) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391021.2" /db_xref="EnsemblGenomes-Gn:BSU31430" /db_xref="EnsemblGenomes-Tr:CAB15132" /db_xref="InterPro:IPR015053" /db_xref="InterPro:IPR023162" /db_xref="SubtiList:BG12359" /db_xref="UniProtKB/Swiss-Prot:O05234" /translation="MEESHAVREMIKIIAKWDPFKYGEEFYETEAVDVVQAVYDENDP DLLAKSIQQIFETSFEQTLPIASCREVAGQLLFIKNSSSCTP*" gene complement(3048938..3049198) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" promotor_-35 3049188..3049191 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-35" promotor_-10 3049206..3049225 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-10" upshifts 3049218 /Source="Nicolas_upshifts" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" S_feature 3049219..3049284 /Source="Nicolas_S_feature" /locus_tag="new_3228712_3228777" /HighExp="dia15, dia5, Lbexp, dia0, LBGtran, G180, Diami, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1204" promotor_-10 complement(3049224..3049243) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3049229) /Source="Nicolas_upshifts" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" promotor_-35 complement(3049255..3049261) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3049285..3050448 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" /EC_number="4.4.1.1" /EC_number="4.4.1.13" /EC_number="4.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15760717, 26337367, 28895253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15760717, 26337367, 28895253; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous cystathionine / cystine beta-lyase /cysteine desulfhydrase" /protein_id="NP_391022.1" /db_xref="EnsemblGenomes-Gn:BSU31440" /db_xref="EnsemblGenomes-Tr:CAB15133" /db_xref="GOA:Q08432" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR027619" /db_xref="SubtiList:BG10744" /db_xref="UniProtKB/Swiss-Prot:Q08432" /translation="MNFDKREERLGTQSVKWDKTGELFGVTDALPMWVADMDFRAPEA ITEALKERLDHGIFGYTTPDQKTKDAVCGWMQNRHGWKVNPESITFSPGVVTALSMAV QAFTEPGDQVVVQPPVYTPFYHMVEKNGRHILHNPLLEKDGAYAIDFEDLETKLSDPS VTLFILCNPHNPSGRSWSREDLLKLGELCLEHGVTVVSDEIHSDLMLYGHKHTPFASL SDDFADISVTCAAPSKTFNIAGLQASAIIIPDRLKRAKFSASLQRNGLGGLNAFAVTA IEAAYSKGGPWLDELITYIEKNMNEAEAFLSTELPKVKMMKPDASYLIWLDFSAYGLS DAELQQRMLKKGKVILEPGTKYGPGGEGFMRLNAGCSLATLQDGLRRIKAALS*" gene 3049285..3050448 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" promotor_-35 3050511..3050517 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3050529..3050548 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3050539 /Source="Nicolas_upshifts" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" CDS 3050574..3051860 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" /EC_number="2.7.13.3" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9426145, 11069677, 15849754, 16850406, 26152584, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 11069677, 15849754, 16850406, 26152584, 28583948; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-binding histidinekinase" /protein_id="NP_391023.2" /db_xref="EnsemblGenomes-Gn:BSU31450" /db_xref="EnsemblGenomes-Tr:CAB15134" /db_xref="GOA:Q08430" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10745" /db_xref="UniProtKB/Swiss-Prot:Q08430" /translation="MEILKDYLLHICFILFPILLYQVFWLGKPAILVPKINSGLVTLF ACGASVLCIIFPIHEMDYIQYGLQMIPVIICLFYISTASGLTVAASVLCFELLFYEPS AMFVFTLLPFLIIIPILFQKKWPFMSKAKKLLLSLLISCVEIFLFFASSWILSALNIL NFQKSGIFVYEAAVSGLFRSSVLLLSIYIIESIAENIALRSQLIHSEKMTIVSELAAS VAHEVRNPLTVVRGFVQLLFNDETLQNKSSADYKKLVLSELDRAQGIITNYLDMAKQQ LYEKEVFDLSALIKETSSLMVSYANYKSVTVEAETEPDLLIYGDATKLKQAVINLMKN SIEAVPHGKGMIHISAKRNGHTIMINITDNGVGMTDHQMQKLGEPYYSLKTNGTGLGL TVTFSIIEHHHGTISFNSSFQKGTTVTIKLPADLPH*" gene 3050574..3051860 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" S_feature complement(3051576..3052318) /Source="Nicolas_S_feature" /locus_tag="new_3231069_3231811_c" /HighExp="BT, S8, B36, S6, S7, S5, S3, S4, Cold, Pyr" /AntisenseName="kapB" /AntisenseCor="-0.71681066342113797" /AntisenseRegPval="-43" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigK" /TUshortPSig="0.709, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1205" promotor_-35 3051855..3051862 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3051876..3051895 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3051877 /Source="Nicolas_upshifts" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" CDS 3051906..3052292 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9426145, 23335417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 23335417; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for KinB signal transduction andactivation of the phosphorelay to sporulation" /protein_id="NP_391024.1" /db_xref="EnsemblGenomes-Gn:BSU31460" /db_xref="EnsemblGenomes-Tr:CAB15135" /db_xref="GOA:Q08429" /db_xref="InterPro:IPR014916" /db_xref="SubtiList:BG10746" /db_xref="UniProtKB/Swiss-Prot:Q08429" /translation="MSTFETGSIVKGFYKTGVYIGEITACRPQHYLVKVKAVLTHPAQ GDLHHPKQADVPFFHERKALAYGEQTNIPHHMVKPYDGEVPDYTESLREATAQMRAKL NEDGSEWAKRSLHNLDILEKEYFNRP*" gene 3051906..3052292 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" downshifts 3052274 /Source="Nicolas_upshifts" /id="D1632" /incds=0 /nref=209 /ntot=249 /MaxReadThrough="1.62013" /MaxDrop="5.57132" /score="1.97959632" /energy="-9.2" /TU="NA" /idTUdmin="U2452" /TUdmin=0 /isTUend="TRUE" CDS complement(3052319..3052936) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" /EC_number="3.1.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27188294; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exoribonuclease (3'-5')" /protein_id="NP_391025.1" /db_xref="EnsemblGenomes-Gn:BSU31470" /db_xref="EnsemblGenomes-Tr:CAB15136" /db_xref="GOA:O05231" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12358" /db_xref="UniProtKB/Swiss-Prot:O05231" /translation="MTTNSLLIIDFEFTMPDGKYSPQNFFPEIIEAGIVKSIDDEVVE TFSSYVRPKKFPKLTKRCKSFLKITQKQVDEGMRFEDFIRKLNELDPEKNSTIITWGN MDMKVLKQNCMFNHIPFPFKGEMRDLSLEYKNFFGDRTLTGLWKAAEEYGDSGTGTHH KALDDALTAYKLFKLVEQDKQYLEKPKPPTIGERIDLTELLKRAT*" gene complement(3052319..3052936) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" promotor_-10 complement(3052971..3052989) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3052988) /Source="Nicolas_upshifts" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" S_feature complement(3052990..3055078) /Source="Nicolas_S_feature" /locus_tag="new_3232483_3234571_c" /HighExp="S8, BT, B36, S7, S6, Pyr, C30, B60, S5, G135" /AntisenseName="yuxJ" /AntisenseCor="-0.168930816447634" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1206" promotor_-35 complement(3053004..3053009) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3053052..3053055 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-35" promotor_-10 3053070..3053089 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-10" upshifts 3053081 /Source="Nicolas_upshifts" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" CDS 3053147..3054325 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter induced in acid stress" /protein_id="NP_391026.2" /db_xref="EnsemblGenomes-Gn:BSU31480" /db_xref="EnsemblGenomes-Tr:CAB15137" /db_xref="GOA:P40760" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10976" /db_xref="UniProtKB/Swiss-Prot:P40760" /translation="MWLANFFVSASTTMIVPFLSLYIETLSSFSNGFVQRWSGYVFGI TFLMAFLVSPFWGRFGDKRGYKKILMATGTGIALSIFFMGFVTSVYQLFFLRMAMGLV TGFIPTSLAMISAQTPKSSAGKTLGTLQMGQVSGSLFGPLLGGMLADRFGFTYTFFIT SFVIFSSVLLVLFGVKEKHLAEKTAKRTSYSRKEVLSYIFHHPALWVMMLLTMLIQTG NFSIQPLLALYVNELHGPVNLAFFSGMAFSATGLGSLLLARKWGDLGDRYGHRRILIG LLLAASFFFIPQALASSLSVLLVFRFLFGMAMGGLLPCITAAIRVQAPGSIQGEVLGY NVSFRFLGNVLGPLLGGIISSHFTISATFYVTAFLFFAGACMLWIMQKLRKDSYAKAS *" gene 3053147..3054325 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" promotor_-35 3054363..3054369 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3054381..3054400 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3054386 /Source="Nicolas_upshifts" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" CDS 3054418..3056292 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" /EC_number="2.-.-.-" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7961491, 9274030; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4" /protein_id="NP_391027.2" /db_xref="EnsemblGenomes-Gn:BSU31490" /db_xref="EnsemblGenomes-Tr:CAB15138" /db_xref="GOA:P40750" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10977" /db_xref="UniProtKB/Swiss-Prot:P40750" /translation="MTMLRKIIGWILLLCIIPLFAFTVIASGKEVKQMKSLDQVLDKN IDLKDISLVQNSYMYDRDGSLVSEIVSDHENRVLVPFNKIPEEVKQIFLTSEDRHFYE HKGFDFMGMVRATASNVKDKKIDQGASTITQQLSRNLYLSHERSFSRKLTELAYSYQL EKKYTKNEILEAYLNTIYFNNGVYGVGSAAQFYFSKPLKSLTVGEMAFICAIPNNPTL YDPLKHFDYTKSRQERLLKGLKDAGVITDKELKKAVKQKIKLDVEKREDKYPDYVSYV NDEFTQLVSESEGFDKRLQKASGKQKEKIENELSARVSTLMKDGVKIYTALDPYMQNQ VVAQMNSKLPYADVQGGAAVINHQTHQIIALSGGKNYQKYDFNRAYQAYRQPGSSIKP LLDYGPYIEQTGATTSSTIDASKFCSKDYCPQNYNNRTYGTVTLDTAFKNSYNTPAIR MLDRVGIQKAFSYIEPYHFAKLVDSDYLLPAALGGFTNGMTPLEMTKAYTTFGNSGSY TPSHAITKVTDLKGKTLYKWNDKATQIFSVRTNMQLKKLMSSVVKSGTGKKAYFNAPY IGGKTGTSNDYHDMWFVGLTDTYTMGVWVGKDTPTSVEYLHSISPQLSIWKGTLQAAY *" gene 3054418..3056292 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" promotor_-10 complement(3055058..3055077) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3055078) /Source="Nicolas_upshifts" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" promotor_-35 complement(3055091..3055100) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3056313..3056726 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26335199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase" /protein_id="NP_391028.1" /db_xref="EnsemblGenomes-Gn:BSU31500" /db_xref="EnsemblGenomes-Tr:CAB15139" /db_xref="InterPro:IPR007263" /db_xref="SubtiList:BG10978" /db_xref="UniProtKB/Swiss-Prot:P40761" /translation="MTSEQIPNRVLLFDGVCNLCNGAVQFIIKRDPDGLISFTSLQSE TGQSLLKKSGLPTDRFDSFVFIEDGQVYTKSTAAIKVFRHLRGPWRLFVLFFAVPKPV RDMVYSFIAKNRYKWFGKKNECMLPSPSIKKRFLP*" gene 3056313..3056726 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" downshifts 3056718 /Source="Nicolas_upshifts" /id="D1633" /incds=0 /nref=1 /ntot=254 /MaxReadThrough="5.05064" /MaxDrop="3.14634" /score="-3.58105315" /energy="-11.5" /TU="U2456" /idTUdmin="U2456" /TUdmin="-22" /isTUend="TRUE" CDS complement(3056929..3057486) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391029.2" /db_xref="EnsemblGenomes-Gn:BSU31510" /db_xref="EnsemblGenomes-Tr:CAB15140" /db_xref="GOA:O05249" /db_xref="InterPro:IPR035289" /db_xref="SubtiList:BG12346" /db_xref="UniProtKB/Swiss-Prot:O05249" /translation="MKNTYLTGYFPLIAILLFSSSLSISTSLYALKMLSSFGMYDGML DYFSEKGIRLALFAAFALLYFMVLSALKLIANTVTELSLLFFANDPEGNNLKKLRMGS MIYLGGGILSFVLLQNVIWIVIWFAVVTLAYFVFTVYRIYSTLSLMSLVGFILLELLF WFTFVIGILFIFIKLYNSIMASLPV*" gene complement(3056929..3057486) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" misc_feature 3056950..3056969 /Source="Nicolas_upshift_promotors" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3056960 /Source="Nicolas_upshifts" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" downshifts complement(3056970) /Source="Nicolas_upshifts" /id="D1634" /incds=0 /nref=10 /ntot=201 /MaxReadThrough="3.90201" /MaxDrop="3.94501" /score="-6.00543052" /energy="-18.5" /TU="U2459" /idTUdmin="U2459" /TUdmin="-132" /isTUend="FALSE" S_feature 3056982..3057663 /Source="Nicolas_S_feature" /locus_tag="new_3236475_3237156" /HighExp="Diami, Cold, LBGstat, H2O2, Lbtran, Gly, M0t90, GM 10, GM-0.2, dia15" /AntisenseName="yufK" /AntisenseCor="0.32488342936044701" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.878" /TUlongSig="NA" /TUlongPSig="NA" /label="S1207" promotor_-10 complement(3057512..3057531) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3057520) /Source="Nicolas_upshifts" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" promotor_-35 complement(3057547..3057551) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3057664..3059265 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [MaeM]" /protein_id="NP_391030.1" /db_xref="EnsemblGenomes-Gn:BSU31520" /db_xref="EnsemblGenomes-Tr:CAB15141" /db_xref="GOA:O05250" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12347" /db_xref="UniProtKB/Swiss-Prot:O05250" /translation="MKKTLKLQTRLTIFVCIVVLIALLITFFTVGAQTTKRIRDQEKA TALQTAEMVAEAPMTAAALESGKKQKELQSYTKRVQKITGTEFVVVMDMNGIRKTHPD PSKIGKKFRGGDESEVLKGHVHISTASGTLGKSQRAFVPVYAENGKQVGAVAVGITVN EIDEVISHSLRPLYFIICVSIFVGVIGAVIVARTVKNIMYGLEPYEIATLLEERSAML ESTKEGILAVDEHGKIKLANAEAKRLFVKMGINTNPIDQDVDDILPKSRLKKVIETKK PLQDRDVRINGLELVFNEVPIQLKGQTVGAIATFRDKTEVKHLAEQLSGVKMYANALR AQSHEFMNKLHVILGLVQLKEYDDLGDYIKDIAIQQKSETSEIINDVKSSVLAGFLLG KQSFIREQGANLDIECNGVIPNAADPSVIHELITIIGNLINNGLDAVADMPKKQITMS MRFHNSILDIEITDTGAGMSEEDQAKVFEQGYSTKGKNRGFGLYFTQQSIENLKGQMI LTSEKNEGTTFSIRIPYEPKEENHD*" gene 3057664..3059265 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" CDS 3059258..3059965 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator for malate metabolism [MaeL]" /protein_id="NP_391031.1" /db_xref="EnsemblGenomes-Gn:BSU31530" /db_xref="EnsemblGenomes-Tr:CAB15142" /db_xref="GOA:O05251" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12348" /db_xref="UniProtKB/Swiss-Prot:O05251" /translation="MINVLIVEDDPMVGELNKRYLSQIDGFQLKGIASSFQSALHILG EHHIDLILLDIYMPGKNGLELLTELRAQNEAVDVIVISAASELDVIKKTLRYGAVDYL IKPFEFERFQTALSDYRRKQKVYSTHRNMSQKELDAELFQKKEATEKVQLPKGLTKST LKLIWSSIQSFENESFTTEDLAKHTEISQVSIRKYLKFLEDIQVLNVEMAYGTIGRPV FQYNVNNSNINGIKQYL*" gene 3059258..3059965 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" downshifts 3059950 /Source="Nicolas_upshifts" /id="D1635" /incds=0 /nref=173 /ntot=245 /MaxReadThrough="1.97489" /MaxDrop="5.86018" /score="19.9464971" /energy="-15.3" /TU="NA" /idTUdmin="U2458" /TUdmin=2660 /isTUend="FALSE" promotor_-35 3060129..3060136 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3060147..3060436 /Source="Nicolas_S_feature" /locus_tag="new_3239640_3239929" /HighExp="T1.30H, T1.0H, T2.30H, T2.0H, M9-stat, S1, T3.0H, T3.30H, T0.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1208" upshifts 3060147 /Source="Nicolas_upshifts" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" promotor_-10 3060151..3060170 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3060437..3061516 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in guanosine transport" /protein_id="NP_391032.2" /db_xref="EnsemblGenomes-Gn:BSU31540" /db_xref="EnsemblGenomes-Tr:CAB15143" /db_xref="GOA:O05252" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12349" /db_xref="UniProtKB/Swiss-Prot:O05252" /translation="MNKRKIGLAMSLVIAAGTILGACGNSEKSSGSGEGKNKFSVAMV TDVGGVDDKSFNQSAWEGIQAFGKENGLKKGKNGYDYLQSKSDADYTTNLNKLARENF DLIYGVGYLMEDSISEIADQRKNTNFAIIDAVVDKDNVASITFKEQEGSFLVGVAAAL SSKSGKIGFVGGMESELIKKFEVGFRAGVQAVNPKAVVEVKYAGGFDKADVGKATAES MYKSGVDVIYHSAGATGTGVFTEAKNLKKEDPKRDVWVIGVDKDQYAEGQVEGTDDNV TLTSMVKKVDTVVEDVTKKASDGKFPGGETLTYGLDQDGVGISPSKQNLSDDVIKAVD KWKKKIIDGLEIPATEKELKTFKAE*" gene 3060437..3061516 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" CDS 3061592..3063124 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 25875741; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanosine ABC transporter (ATP-binding protein)" /protein_id="NP_391033.1" /db_xref="EnsemblGenomes-Gn:BSU31550" /db_xref="EnsemblGenomes-Tr:CAB15144" /db_xref="GOA:O05253" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12350" /db_xref="UniProtKB/Swiss-Prot:O05253" /translation="MEYVIEMLNIRKAFPGIVANDNINLQVKKGEIHALLGENGAGKS TLMNVLFGLYQPERGEIRVRGEKVHINSPNKANDLGIGMVHQHFMLVDTFTVAENIIL GKEPKKFGRIDRKRAGQEVQDISDRYGLQIHPEAKAADISVGMQQRAEILKTLYRGAD ILIFDEPTAVLTPHEIKELMQIMKNLVKEGKSIILITHKLKEIMEICDRVTVIRKGKG IKTLDVRDTNQDELASLMVGREVSFKTEKRAAQPGAEVLAIDGITVKDTRGIETVRDL SLSVKAGEIVGIAGVDGNGQSELIEAVTGLRKTDSGTITLNGKQIQNLTPRKITESGI GHIPQDRHKHGLVLDFPIGENILLQSYYKKPYSALGVLHKGEMYKKARSLITEYDVRT PDEYTHARALSGGNQQKAIIGREIDRNPDLLIAAQPTRGLDVGAIEFVHKKLIEQRDA GKAVLLLSFELEEIMNLSDRIAVIFEGRIIASVNPQETTEQELGLLMAGSTQKEAGKA NG*" gene 3061592..3063124 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" CDS 3063117..3064163 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391034.1" /db_xref="EnsemblGenomes-Gn:BSU31560" /db_xref="EnsemblGenomes-Tr:CAB15145" /db_xref="GOA:O05254" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR002229" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12351" /db_xref="UniProtKB/Swiss-Prot:O05254" /translation="MVKRLSHLLVPLIAIILGLAAGALIMLVSGYSVASGYSALWNGI FGEIYYVGETIRQITPYILSGLAVAFAFRTGLFNIGVEGQLLVGWTAAVWVGTAFDGP AYIHLPLALITAAAAGGLWGFIPGILKARFYVHEVIVTIMMNYIALHMTNYIISNVLT DHQDKTGKIHESASLRSPFLEQITDYSRLHLGIIVALLAAVIMWFIINKSTKGFELRA VGFNQHASQYAGMSVRKNIMTSMLISGAFAGLAGAMEGLGTFEYAAVKGAFTGVGFDG IAVALLGGNTAVGVVLAACLLGGLKIGALNMPIESGVPSEVVDIVIAIIILFVASSYA IRFVMGKLKKKGAN*" gene 3063117..3064163 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" CDS 3064164..3065123 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391035.1" /db_xref="EnsemblGenomes-Gn:BSU31570" /db_xref="EnsemblGenomes-Tr:CAB15146" /db_xref="GOA:O05255" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12352" /db_xref="UniProtKB/Swiss-Prot:O05255" /translation="MDIVQILSIIVPATLVYAAPLILTALGGVFSERSGVVNIGLEGL MIIGAFTSVLFNLFFGQELGAAAPWLSLLAAMAAGALFSLIHAAAAISFRADQTVSGV AINMLALGATLFIVKLIYGKAQTDKIPEPFYKTKIPGLGDIPVLGKIFFSDVYYTSIL AIALAFISWFILFKTPFGLRIRSVGEHPMAADTMGINVYKMRYIGVMISGLFGGLGGG VYASTIALDFTHSTISGQGFIALAALVFGKWHPIGALGAALFFGFAQSLSIIGSLLPL FKDIPNVYMLMAPYILTILALTGFIGRADAPKANGVPYIKGKR*" gene 3064164..3065123 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" S_feature 3065124..3065245 /Source="Nicolas_S_feature" /locus_tag="new_3244617_3244738" /HighExp="S1, BT, M9-stat, T1.30H, S2, LoTm, T1.0H, T2.30H, T2.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1209" promotor_-35 3065218..3065221 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3065236..3065255 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3065247 /Source="Nicolas_upshifts" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" CDS 3065277..3066623 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/malate symporter" /protein_id="NP_391036.1" /db_xref="EnsemblGenomes-Gn:BSU31580" /db_xref="EnsemblGenomes-Tr:CAB15147" /db_xref="GOA:O05256" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12353" /db_xref="UniProtKB/Swiss-Prot:O05256" /translation="MGAIPKTGTISPEQKDSQEKNLFQKIWSWEIGVIPLPLYTVLAV IIILAAYYNELPANMLGGFAIIMILGVFLGDIGQRIPILKDIGGPAILSLFVPSFLVF YNVLNSTSLDAVTNLMKTSNFLYFYIACLVVGSILGMNRIVLIQGFIRMFVPLVAGTI AAVAAGILVGFIFGYSAYDSFFFVVVPIIAGGIGEGILPLSIAYSQILGSSADVFVSQ LVPAAIIGNVFAIICAALMKKLGDKRPDLNGNGRLVKSKKANEIFNQKEAEAKIDFKL MGAGVLLACTFFIFGGLLEKFIFIPGAILMIISAAAVKYANILPKKMEEGAYQLYKFI SSSFTWPLMVGLGILFIPLDDVASVISIPFVIICISVVIAMIGSGYFVGKLMNMYPVE SAIVTCCHSGLGGTGDVAILSASGRMGLMPFAQISTRLGGAGTVICATVLLRFFTS*" gene 3065277..3066623 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" downshifts 3066606 /Source="Nicolas_upshifts" /id="D1636" /incds=0 /nref=68 /ntot=109 /MaxReadThrough="0.286069999999999" /MaxDrop="6.51197" /score="36.240717" /energy="-12.2" /TU="NA" /idTUdmin="U2461" /TUdmin="-12" /isTUend="TRUE" CDS complement(3066659..3066874) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391037.1" /db_xref="EnsemblGenomes-Gn:BSU31590" /db_xref="EnsemblGenomes-Tr:CAB15148" /db_xref="GOA:O05257" /db_xref="SubtiList:BG12354" /db_xref="UniProtKB/Swiss-Prot:O05257" /translation="MKTKVVMCSGLFCSVFAGAFMLNQYDGRSGVAACDEWELYLLEH HLSARMSETESKDLPFGPREYIRIVNK*" gene complement(3066659..3066874) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" promotor_-35 3066814..3066820 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3066834..3066845 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3066838 /Source="Nicolas_upshifts" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3066885..3066903) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3066892) /Source="Nicolas_upshifts" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" promotor_-35 3066917..3066924 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3066919..3066924) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3066939..3067034 /Source="Nicolas_S_feature" /locus_tag="new_3246432_3246527" /HighExp="G180, Diami, G150, Oxctl, G135, H2O2, Paraq, MG 60, MG 15, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1210" promotor_-10 3066939..3066958 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3066939 /Source="Nicolas_upshifts" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" promotor_-35 3066997..3067001 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3067017..3067036 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3067036..3067185 /Source="Nicolas_S_feature" /locus_tag="new_3246529_3246678" /HighExp="G135, G180, Diami, G150, H2O2, Oxctl, LBGexp, Paraq, Salt, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1211" upshifts 3067036 /Source="Nicolas_upshifts" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" CDS 3067105..3069510 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium transporter component of a Na+/H+ antiporter" /protein_id="NP_391038.2" /db_xref="EnsemblGenomes-Gn:BSU31600" /db_xref="EnsemblGenomes-Tr:CAB15149" /db_xref="GOA:Q9K2S2" /db_xref="InterPro:IPR001516" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR005663" /db_xref="InterPro:IPR018393" /db_xref="InterPro:IPR025383" /db_xref="SubtiList:BG12355" /db_xref="UniProtKB/Swiss-Prot:Q9K2S2" /translation="MQLLHLAILSPFLFAFIIPFLAKYAKRVHTGWFVLILPVLLFIY FLPMIRMTQSGETLRSVLEWIPSLGINFTVYIDGLGLLFALLITGIGSLVTLYSIFYL SKEKEQLGPFYVYLLMFMGAMLGVVLVDNVMVLYMFWELTSLSSFLLIGYWYKREKSR YGAAKSLLITVSGGLCMLGGFILLYLITDSFSIREMVHQVQLIAGHELFIPAMILILL GAFTKSAQFPFYIWLPDAMEAPTPVSAYLHSATMVKAGIYVIARFSPIFAFSAQWFWI VSLVGLFTMVWGSFHAVKQTDLKSILAFSTVSQLGMIISMLGVSAAALHYGHTEYYTV AAMAAIFHLINHATFKGSLFMAVGIIDHETGTRDIRKLGGLMAIMPITFTISLIGTFS MAGLPPFNGFLSKEMFFTSMLRVTHFDLFNVQTWGVLFPLFAWIGSVFTFIYSMKLLF KTFRGNYQPEQLEKQAHEAPVGMLVPPVILVALAVSLFFFPNILSYSLIEPAMNSIYP TLLDGHEKFHVHISQWHGVTTELLMTAGIVVIGTIGYLSLNKWKGIYKLFPSKLTLNR LYDKLLTMMEKGSYRVTKQYMTGFLRDYLLYIFAGFIILIGGAFAIKGGFSFKTEGMA KIGVYEIILTLVMISATVATVFARSRLTAIIALGVVGYTLALFFVIFRAPDLALTQLV IETISVALFLLCFYHLPKLRLKTKTRTFRMTNFIISLGVGVIVTLLGIASSSQRTKDS IASFFVKHSHDLGGGDNVVNVILVDFRGFDTMFEITVLTIAALGIYSMIKTKVKEEGK SGE*" gene 3067105..3069510 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" CDS 3069503..3069934 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter complex" /protein_id="NP_391039.1" /db_xref="EnsemblGenomes-Gn:BSU31610" /db_xref="EnsemblGenomes-Tr:CAB15150" /db_xref="GOA:O05259" /db_xref="InterPro:IPR005281" /db_xref="InterPro:IPR007182" /db_xref="SubtiList:BG12356" /db_xref="UniProtKB/Swiss-Prot:O05259" /translation="MNEQKTNDLILQTATKLVSFIILLFSFYLFLSGHNAPGGGFVGG LITSSSIVLLLLAYDLKTVRSLLPVNFIYVAGAGLLLAVLTGVGSFVFGAPFLTHTFG YFQLPILGKTELATATIFDLGVYLVVVGITMTIIQTIGEEE*" gene 3069503..3069934 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" CDS 3069934..3070275 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of Na+/H+ antiporter" /protein_id="NP_391040.2" /db_xref="EnsemblGenomes-Gn:BSU31620" /db_xref="EnsemblGenomes-Tr:CAB15151" /db_xref="GOA:O05260" /db_xref="SubtiList:BG12357" /db_xref="UniProtKB/Swiss-Prot:O05260" /translation="MEILMAVLAGIIFMAATYLLLSKSLLRVIIGTALLSHGVHLMLL TMGGLKKGAAPILSEHAKSFVDPLPQALILTAIVISFGVTSFILVMAFRAYQELKSDD MDQMRGNDQHE*" gene 3069934..3070275 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" promotor_no_box 3070166..3070266 /Source="Nicolas_upshift_promotors" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3070226 /Source="Nicolas_upshifts" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" CDS 3070268..3071749 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton transporter component of Na+/H+ antiporter" /protein_id="NP_391041.3" /db_xref="EnsemblGenomes-Gn:BSU31630" /db_xref="EnsemblGenomes-Tr:CAB15152" /db_xref="GOA:O05229" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR003918" /db_xref="InterPro:IPR004775" /db_xref="SubtiList:BG12345" /db_xref="UniProtKB/Swiss-Prot:O05229" /translation="MNNFVILPILIPLLSAILLIFMTKNLMLMRIFSTAASAIGIVIS GILVQTVFTKGIQTLSLGGWKAPYGIVLAADQFASLLVLTTAIIGLLVGLYSFRSVGE KRERSFYYSGVQFLLAGVSGAFLTGDLFNMYVFFELLLIASYMLIVLGGTKIQLRESL KYIVFNIVSSALFVIGVGFLYAVTGTLNMADLSVKISESGQTGLITVIGVLLLLVFGM KGGIFPLYFWLPGSYYAPPAAISALFGALLTKVGLYAITRVFTLIFIHDTAFTHQLMI WLAALTVIFGVIGSLAYSNVMKIVIYNIITAVGVILFGVAVHTPASIQGAIYYLIHDM LIKGALFMLAGTLIALTGTASLHKMGGLIKRYPVLGWMFFISAISLAGIPPLSGFVGK FKIAEGGFAEGEFTISMLILLSSLLVLYSVLRIFIHAFWGEEKETPKPNHRTAKGLLY PAAIFLLLSLLFGLGTEWVSPYVDQAAETLLNPEKYIEAVLKE*" gene 3070268..3071749 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" S_feature complement(3071001..3072869) /Source="Nicolas_S_feature" /locus_tag="new_3250494_3252362_c" /HighExp="S2, Lbstat, T5.0H, T3.30H, S3, T4.0H, T3.0H, T2.30H, S1, T2.0H" /AntisenseName="mrpD" /AntisenseCor="-0.59706140653928796" /AntisenseRegPval="-26.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1212" CDS 3071755..3072231 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 15849754, 16233411, 16850406, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 15849754, 16233411, 16850406, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="YP_054591.2" /db_xref="EnsemblGenomes-Gn:BSU31640" /db_xref="EnsemblGenomes-Tr:CAE01465" /db_xref="GOA:Q7WY60" /db_xref="InterPro:IPR002758" /db_xref="SubtiList:BG14181" /db_xref="UniProtKB/Swiss-Prot:Q7WY60" /translation="MAFQILLNVFLAFCWMFLSNSPSAAGFITGYILGMLSLFFFRRF FTRQFYLWKLISIIKLCFIFIKELYLANVSVMKSVLSPKLNIRPGIFAFKTELTKDWE ITMLSLLITLTPGTLVMDISDDRTILYIHAMDIEDAEKAIFDIRESFEKAIQEVSR*" gene 3071755..3072231 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" CDS 3072231..3072515 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 11356194, 12682299, 15019740, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 11356194, 12682299, 15019740, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter for Na+ and cholate" /protein_id="NP_391043.2" /db_xref="EnsemblGenomes-Gn:BSU31650" /db_xref="EnsemblGenomes-Tr:CAB15153" /db_xref="GOA:O05228" /db_xref="InterPro:IPR007208" /db_xref="SubtiList:BG12344" /db_xref="UniProtKB/Swiss-Prot:O05228" /translation="MFTLILQIALGIMAVSTFLYVIRVIKGPTVPDRVVALDAIGINL IAITALVSILLKTSAFLDIILLLGILSFIGTIAFSKFLEKGEIIENDRNR*" gene 3072231..3072515 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" CDS 3072499..3072873 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 15019740, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 15019740, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="NP_391044.1" /db_xref="EnsemblGenomes-Gn:BSU31660" /db_xref="EnsemblGenomes-Tr:CAB15154" /db_xref="GOA:O05227" /db_xref="InterPro:IPR005133" /db_xref="SubtiList:BG12343" /db_xref="UniProtKB/Swiss-Prot:O05227" /translation="MIETAKVVVAVFILLGALICLIASFGVLRLPDVFTRAHAASKGS TLGVNMILLGVFFYLWFVTGELSAKILLGILFIFITSPIGGHLICRAAYNSGVKLDER SVQDDYNGIRNFVIKRKEDSYL*" gene 3072499..3072873 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" downshifts 3072844 /Source="Nicolas_upshifts" /id="D1637" /incds=0 /nref=86 /ntot=185 /MaxReadThrough="1.46493" /MaxDrop="6.023" /score="32.1865197" /energy="-12.7" /TU="NA" /idTUdmin="U2464" /TUdmin=0 /isTUend="TRUE" CDS complement(3072912..3073292) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" /EC_number="3.1.-.-" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25010423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proofreading thioesterase in bacillibactin biosynthesis" /protein_id="NP_391045.2" /db_xref="EnsemblGenomes-Gn:BSU31670" /db_xref="EnsemblGenomes-Tr:CAB15155" /db_xref="GOA:P14205" /db_xref="InterPro:IPR003736" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10382" /db_xref="UniProtKB/Swiss-Prot:P14205" /translation="MDMKHTLLEALGIEIVENTAERCVAVMPVDHRTVQPFGYLHGGA SVALAETAASAGAQNLIDHTTQACVGLEINANHLKSVKEGTVKAIAEPVHIGRTTIVY HIHIYDEQERLICISRCTLAVIKK*" gene complement(3072912..3073292) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" downshifts complement(3072914) /Source="Nicolas_upshifts" /id="D1638" /incds=0 /nref=41 /ntot=206 /MaxReadThrough="4.53972" /MaxDrop="3.98532" /score="-4.4938943" /energy="-12.7" /TU="U2469" /idTUdmin="U2469" /TUdmin="-1050" /isTUend="FALSE" CDS complement(3073311..3073955) /gene="comA" /locus_tag="BSU_31680" /old_locus_tag="BSU31680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response quorum-sensing regulator" /protein_id="NP_391046.1" /db_xref="EnsemblGenomes-Gn:BSU31680" /db_xref="EnsemblGenomes-Tr:CAB15156" /db_xref="GOA:P14204" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2KRF" /db_xref="PDB:3ULQ" /db_xref="SubtiList:BG10381" /db_xref="UniProtKB/Swiss-Prot:P14204" /translation="MKKILVIDDHPAVMEGTKTILETDSNLSVDCLSPEPSEQFIKQH DFSSYDLILMDLNLGGEVNGMELSKQILQENPHCKIIVYTGYEVEDYFEEAIRAGLHG AISKTESKEKITQYIYHVLNGEILVDFAYFKQLMTQQKTKPAPSSQKEQDVLTPRECL ILQEVEKGFTNQEIADALHLSKRSIEYSLTSIFNKLNVGSRTEAVLIAKSDGVL*" gene complement(3073311..3073955) /gene="comA" /locus_tag="BSU_31680" /old_locus_tag="BSU31680" S_feature complement(3073956..3074035) /Source="Nicolas_S_feature" /locus_tag="new_3253449_3253528_c" /HighExp="S2, Lbstat, M0t90, M40t90, MG 5, S1, ferm, T1.30H, nit, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1213" CDS complement(3074036..3076345) /gene="comP" /locus_tag="BSU_31690" /old_locus_tag="BSU31690" /EC_number="2.7.-.-" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7698645, 7855425, 10419951, 14679219, 15066026, 16091050, 16787201, 20208433, 24130811; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_391047.2" /db_xref="EnsemblGenomes-Gn:BSU31690" /db_xref="EnsemblGenomes-Tr:CAB15157" /db_xref="GOA:Q99027" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10380" /db_xref="UniProtKB/Swiss-Prot:Q99027" /translation="MKNLIKKFTIAVIVLSILYISYTTYISMNGIIIGTKIHKNDKSQ FMIEEISESSYGQFVGLRQGDIILKINKEKPSDKHLKWGYLSHINSLDILRSGKKIHL KDFDLVTLNRPYSFFLFVLPLFFYFLSIICIFYILKVNKKRRSFAAYILILLLLDISI AYISAGGPFRGHIINRYINLFTFISSPILYLQFIQRYLGEIGKTFLNRISFLYIIPIF NLGIEFFQDYLQVDIDFLATLNLVSFATLTLFSFSAIYLHLNKYKYAEHSFILKLLIL TNTLSFAPFLIFFVLPIIFTGNYIFPALASASLLVLIPFGLVYQFVANKMFDIEFILG RMRYYALLAMIPTLLIVGALVLFDVMDIQMNPVRQTVFFFVVMFAVFYFKEVMDFKFR LKRFSEKFNYQDSIFKYTQLMRGVTSLQQVFKELKNTILDVLLVSKAYTFEVTPDHKV IFLDKHEVGPDWNFYQEEFENVTSEIGKIIEVNQGFLMKVGERGGSSYVLLCLSNINT PRLTRDEISWLKTLSFYTSVSMENVLHIEELMEHLKDLKQEGTNPIWLKKLMFAIEEK QRSGLARDLHDSVLQDLISLKRQCELFLGDFKKDDNPCREEVQDKLVQMNEQMSDVIS MTRETCHELRPQLLYDLGLVKALSKLVAQQQERVPFHIRLNTGRFTASLDLDSQLNLY RIIQEFLSNAVKHSQATDVLIMLISIQNKIVLHYEDDGVGFDQEKNTEHSMSMGLSGI KERVRALDGRLRIETSEGKGFKADIEIEL*" gene complement(3074036..3076345) /gene="comP" /locus_tag="BSU_31690" /old_locus_tag="BSU31690" promotor_-35 3075030..3075037 /Source="Nicolas_upshift_promotors" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3075051..3075070 /Source="Nicolas_upshift_promotors" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3075066 /Source="Nicolas_upshifts" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature 3075939..3076911 /Source="Nicolas_S_feature" /locus_tag="new_3255432_3256404" /HighExp="S8, C30, S7, Gly, Lbstat, Fru, C90, Pyr, G135, M/G" /AntisenseName="comX" /AntisenseCor="-2.6572990440080099E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.606" /TUlongSig="NA" /TUlongPSig="NA" /label="S1214" upshifts 3075939 /Source="Nicolas_upshifts" /id="U2468" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.281718281718282" /psig="0.606393606393606" /xcortree=660 /SigmaFactorBS="aataacaatagaataagaatataggcagcaaatgatctcctt tttttatttactttaagtatataaaaaataCATATTATGCTTAAAAAataaaaaaaca a" /listShort="S1214" /GFF_Attribute="listLong" misc_feature 3075951..3075967 /Source="Nicolas_upshift_promotors" /id="U2468" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.281718281718282" /psig="0.606393606393606" /xcortree=660 /SigmaFactorBS="aataacaatagaataagaatataggcagcaaatgatctcctt tttttatttactttaagtatataaaaaataCATATTATGCTTAAAAAataaaaaaaca a" /listShort="S1214" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3076360..3076527) /gene="comX" /locus_tag="BSU_31700" /old_locus_tag="BSU31700" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11751817, 12067344, 14679219, 16407988, 17240141, 18323630, 21636272, 21821957, 28326143, 28391484" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751817, 12067344, 14679219, 16407988, 17240141, 18323630, 21636272, 21821957, 28326143, 28391484; Product type f: factor" /codon_start=1 /transl_table=11 /product="competence pheromone precursor (pheromone peptide aa 46->55, geranyl-modified)" /protein_id="NP_391048.1" /db_xref="EnsemblGenomes-Gn:BSU31700" /db_xref="EnsemblGenomes-Tr:CAB15158" /db_xref="GOA:P45453" /db_xref="InterPro:IPR009233" /db_xref="SubtiList:BG11324" /db_xref="UniProtKB/Swiss-Prot:P45453" /translation="MQDLINYFLNYPEALKKLKNKEACLIGFDVQETETIIKAYNDYY LADPITRQWGD*" gene complement(3076360..3076527) /gene="comX" /locus_tag="BSU_31700" /old_locus_tag="BSU31700" CDS complement(3076515..3077414) /gene="comQ" /locus_tag="BSU_31710" /old_locus_tag="BSU31710" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751817, 12067344, 14679219, 16407988, 16452308, 17240141, 22878193, 24425772, 25036949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751817, 12067344, 14679219, 16407988, 16452308, 17240141, 22878193, 24425772, 25036949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoprenyl transferase (pre-ComX modification)" /protein_id="NP_391049.2" /db_xref="EnsemblGenomes-Gn:BSU31710" /db_xref="EnsemblGenomes-Tr:CAB15159" /db_xref="GOA:P33690" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033965" /db_xref="SubtiList:BG10379" /db_xref="UniProtKB/Swiss-Prot:P33690" /translation="MKEIVEQNIFNEDLSQLLYSFIDSKETFSFAESTILHYVVFGGE NLDVATRLGAGIEILILSSDIMDDLEDEDNHHALWMKINRSESLNAALSLYTVGLTSI YSLNNNPLIFKYVLKYVNEAMQGQHDDITNKSKTEDESLEVIRLKCGSLIALANVAGV LLATGEYNETVERYSYYKGIIAQISGDYYVLLSGNRSDIEKNKHTLIYLYLKRLFNDA SEDLLYLISHKDLYYKSLLDKEKFQEKLIKAGVTQYISVLLEIYKQKCISAIEQLNLD KEKKELIKECLLSYTKGDTRCKT*" gene complement(3076515..3077414) /gene="comQ" /locus_tag="BSU_31710" /old_locus_tag="BSU31710" S_feature complement(3077415..3077528) /Source="Nicolas_S_feature" /locus_tag="new_3256908_3257021_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, S4, T2.30H, M0t90, S5, M40t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1215" promotor_-10 complement(3077522..3077541) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3077528) /Source="Nicolas_upshifts" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" promotor_-35 complement(3077555..3077561) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3077599..3077739) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="pleiotropic regulator" /protein_id="NP_391050.1" /db_xref="EnsemblGenomes-Gn:BSU31720" /db_xref="EnsemblGenomes-Tr:CAB15160" /db_xref="GOA:Q99039" /db_xref="InterPro:IPR012554" /db_xref="SubtiList:BG10378" /db_xref="UniProtKB/Swiss-Prot:Q99039" /translation="MEKKLEEVKQLLFRLELDIKETTDSLRNINKSIDQLDKYNYAMK IS*" gene complement(3077599..3077739) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" downshifts complement(3077628) /Source="Nicolas_upshifts" /id="D1639" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="2.48672" /MaxDrop="4.10905" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2470" /TUdmin=0 /isTUend="TRUE" S_feature complement(3077740..3077826) /Source="Nicolas_S_feature" /locus_tag="new_3257233_3257319_c" /HighExp="S2, S4, BC, M9-stat, S5, S3, S6, BT, S8, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.843" /TUlongSig="NA" /TUlongPSig="NA" /label="S1216" promotor_-10 complement(3077810..3077829) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3077826) /Source="Nicolas_upshifts" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" promotor_-35 complement(3077843..3077849) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3077926..3077944) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3077936) /Source="Nicolas_upshifts" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3077959..3077965) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3077961..3078086 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514001.1" /translation="MLKLRKILNLLDFNGFRIFTKQDYSPSYRIFKIEYAILGVS*" gene 3077961..3078086 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" S_feature complement(3078114..3078543) /Source="Nicolas_S_feature" /locus_tag="new_3257607_3258036_c" /HighExp="LBGtran, G135, C90, Lbtran, Mt0, Lbexp, G150, G180, M40t45, C30" /AntisenseName="yuzC" /AntisenseCor="-0.77553193168722701" /AntisenseRegPval="-54.5" /CDS_PredictionProba="0.143959" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1217" promotor_-35 3078139..3078144 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3078156) /Source="Nicolas_upshifts" /id="D1640" /incds=0 /nref=23 /ntot=170 /MaxReadThrough="2.53578" /MaxDrop="3.52021" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2473" /TUdmin=0 /isTUend="TRUE" promotor_-10 3078159..3078177 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3078161 /Source="Nicolas_upshifts" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" CDS 3078200..3078568 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16321932" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391051.2" /db_xref="EnsemblGenomes-Gn:BSU31730" /db_xref="EnsemblGenomes-Tr:CAB15161" /db_xref="InterPro:IPR016559" /db_xref="SubtiList:BG14052" /db_xref="UniProtKB/Swiss-Prot:O32089" /translation="MRYRYPWFYVYPYEVRRPPAPANNIDTFIRSAKQAAGIFADAQL VLSRIAGSRELSRRILTAAEQSDKQTIRRLIKQMGVRHEVDTVFNPDGIYISLIGTQS RMILALRWSEDRNHFASIRL*" gene 3078200..3078568 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" CDS complement(3078544..3079773) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" /EC_number="3.1.4.52" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17153922, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17153922, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclic di-GMP phosphodiesterase" /protein_id="NP_391052.1" /db_xref="EnsemblGenomes-Gn:BSU31740" /db_xref="EnsemblGenomes-Tr:CAB15162" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR013976" /db_xref="InterPro:IPR014408" /db_xref="InterPro:IPR035919" /db_xref="SubtiList:BG10377" /db_xref="UniProtKB/Swiss-Prot:P14203" /translation="MRVFVARQPIFNRKEQVVAYELLYRESEENVYSAKDGDQATTDL VINSFLNIGIEKLTEGKRCFVNFTESLMFSNLPTSFNPKQLVIEILEDIPITPALISR CKELKKMGYMLALDDFYAINPQDEDLLEKLMSYIDILKIDFLKTTRMERRTILQTYGC RGLIFLAEKVETRKEYKQAVQDGFQLFQGYFFSEPRIISGHDLSTHFYSYYELLNELS KEQPNIKRVTEYIERDLSLSYQILKFLNSSHSRLSQKIESIQQAIMLLGFNEIKRWIY ILSFKDLSRKGHSSKHEIIKISLIRAKLCELLARKTSRPQPASYMLIGMFSLIDTLLH REIEEIVQELPLKDEVGQALLGHQNDYYQMLELVKLIESNNWDTCSELGNQLDKEEAY ECYLEALEWCHNLMDAK*" gene complement(3078544..3079773) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" S_feature 3078569..3079882 /Source="Nicolas_S_feature" /locus_tag="new_3258062_3259375" /HighExp="S4, S5, S3, S6, LoTm, S8, S7, T5.0H, B36, Pyr" /AntisenseName="yuxH" /AntisenseCor="-0.78363066752642896" /AntisenseRegPval="-56.4" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1218" promotor_-10 complement(3079808..3079827) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3079827) /Source="Nicolas_upshifts" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" downshifts 3079840 /Source="Nicolas_upshifts" /id="D1641" /incds=0 /nref=6 /ntot=30 /MaxReadThrough="1.76106" /MaxDrop="4.58543" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=0 /isTUend="TRUE" promotor_-35 complement(3079842..3079849) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3079910..3081382) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" /EC_number="6.3.4.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4296374, 12682299, 16199587, 24564896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate phosphoribosyltransferase" /protein_id="NP_391053.1" /db_xref="EnsemblGenomes-Gn:BSU31750" /db_xref="EnsemblGenomes-Tr:CAB15163" /db_xref="GOA:O32090" /db_xref="InterPro:IPR006405" /db_xref="InterPro:IPR007229" /db_xref="InterPro:IPR036068" /db_xref="SubtiList:BG13966" /db_xref="UniProtKB/Swiss-Prot:O32090" /translation="MLEYGFKDDSLSLHTDLYQINMAETYWRDGIHEKKAIFELFFRR LPFENGYAVFAGLEKAIEYLENFKFTDSDLSYLQDELGYHEDFIEYLRGLSFTGSLYS MKEGELVFNNEPIMRVEAPLVEAQLIETALLNIVNYQTLIATKAARIKGVIGDEVALE FGTRRAHEMDAAMWGARAALIGGFSATSNVRAGKRFNIPVSGTHAHALVQAYRDEYTA FKKYAETHKDCVFLVDTYDTLRSGMPNAIRVAKEFGDRINFIGIRLDSGDLAYLSKKA RKMLDEAGFTDAKVIASSDLDEHTIMNLKAQGARIDVWGVGTKLITAYDQPALGAVYK LVAIEEDGKMVDTIKISSNPEKVTTPGRKKVYRIINQSNHHSEGDYIALYDEQVNDQK RLRMFHPVHTFISKFVTNFYAKDLHELIFEKGILCYQNPEISDIQQYVQDNLSLLWEE YKRISKPEEYPVDLSEDCWSNKMQRIHEVKSRIEEELEEE*" gene complement(3079910..3081382) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" downshifts complement(3079920) /Source="Nicolas_upshifts" /id="D1642" /incds=0 /nref=200 /ntot=267 /MaxReadThrough="4.08676" /MaxDrop="6.72747" /score="16.2382739" /energy="-14.5" /TU="NA" /idTUdmin="U2475" /TUdmin="-4" /isTUend="TRUE" misc_feature 3081263..3081267 /Source="Nicolas_upshift_promotors" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3081270 /Source="Nicolas_upshifts" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 3081380 /Source="Nicolas_upshifts" /id="D1643" /incds=0 /nref=1 /ntot=123 /MaxReadThrough="1.2059" /MaxDrop="3.08208" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=1540 /isTUend="FALSE" CDS complement(3081398..3081949) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" /EC_number="3.5.1.19" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15135535, 17382284, 18616465, 24340054, 24512664; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinamidase; NAD salvage pathway" /protein_id="NP_391054.1" /db_xref="EnsemblGenomes-Gn:BSU31760" /db_xref="EnsemblGenomes-Tr:CAB15164" /db_xref="GOA:O32091" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG13965" /db_xref="UniProtKB/Swiss-Prot:O32091" /translation="MKKALICIDYTNDFVASDGKLTCGEPGRMIEEAIVNLTKEFITN GDYVVLAVDSHDEGDQYHPETRLFPPHNIKGTEGKDLYGKLLPLYQKHEHEPNVYYME KTRYSAFAGTDLELKLRERQIGELHLAGVCTDICVLHTAVDAYNKGFRIVVHKQAVAS FNQEGHAWALSHFANSIGAQVAE*" gene complement(3081398..3081949) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" promotor_-10 complement(3081971..3081990) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3081984) /Source="Nicolas_upshifts" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" promotor_-35 complement(3082003..3082010) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3082046..3082444) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391055.1" /db_xref="EnsemblGenomes-Gn:BSU31770" /db_xref="EnsemblGenomes-Tr:CAB15165" /db_xref="InterPro:IPR012543" /db_xref="InterPro:IPR029064" /db_xref="PDB:2OHW" /db_xref="SubtiList:BG13964" /db_xref="UniProtKB/Swiss-Prot:O32092" /translation="MSEDKMDLYLQQGMYGPLETKPDERHLFLGSLRERVVLALTKGQ VLRSKPYKEAEHELKNSHNVTLLINGELQYQSYSSYIQMASRYGVPFKIVSDLQFHTP LGIVIAADIAVNRELIYIQDDIYNRSVLKS*" gene complement(3082046..3082444) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" S_feature complement(3082445..3082515) /Source="Nicolas_S_feature" /locus_tag="new_3261938_3262008_c" /HighExp="Etha, dia5, Diami, dia15, H2O2, LBGtran, LPhT, G135, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1219" CDS complement(3082516..3082764) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391056.1" /db_xref="EnsemblGenomes-Gn:BSU31780" /db_xref="EnsemblGenomes-Tr:CAB15166" /db_xref="InterPro:IPR020260" /db_xref="SubtiList:BG13963" /db_xref="UniProtKB/Swiss-Prot:O32093" /translation="MKIRKANINTQTGMITDVYLHENRKELRTLVAVPQLEWSTIISY EEDKATLPERLEASLRRHTEETPAGELAKKIIHWVTEM*" gene complement(3082516..3082764) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" promotor_-10 complement(3082787..3082806) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3082798) /Source="Nicolas_upshifts" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" promotor_-35 complement(3082822..3082825) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3082837..3083058) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_391057.1" /db_xref="EnsemblGenomes-Gn:BSU31790" /db_xref="EnsemblGenomes-Tr:CAB15167" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13962" /db_xref="UniProtKB/Swiss-Prot:O32094" /translation="MPAIVGPIYIMSVTDNAAASFGDVFAISPKSVAHSGAGSGTFQL GDFVKINNQTSKTLFKDADITDETVSFNG*" gene complement(3082837..3083058) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" downshifts complement(3082864) /Source="Nicolas_upshifts" /id="D1644" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="3.65047" /MaxDrop="4.3681" /score="19.032155" /energy="-12.6" /TU="U2477,U2479,U2482" /idTUdmin="U2482" /TUdmin="-44" /isTUend="FALSE" downshifts 3083052 /Source="Nicolas_upshifts" /id="D1645" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="1.17049" /MaxDrop="3.0193" /score="-7.47675224" /energy="-6.7" /TU="NA" /idTUdmin="U2480" /TUdmin="-1320" /isTUend="FALSE" promotor_-10 complement(3083076..3083095) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3083082) /Source="Nicolas_upshifts" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" promotor_-35 complement(3083108..3083117) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3083118..3084227) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391058.1" /db_xref="EnsemblGenomes-Gn:BSU31800" /db_xref="EnsemblGenomes-Tr:CAB15168" /db_xref="GOA:O32095" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13961" /db_xref="UniProtKB/Swiss-Prot:O32095" /translation="MLKSKVHFWTLQILFVLLIIFVATKVSFVFQPFIVFISTLFFPM LIAGILYFIFNPVVRLLEKKIPRTLSILLIYLLFIGLLAFISASVGPIITAQVTGLFN NLPDYIKQIQALTKDLSHSQWFTWMMNQDYVSISKIEQSLTSFLQNLPQNITSSLSAV FGVVTNITLVIITVPFILFYMLKDGHRFPHLAVKILPASYRTEGLKIFKDLSDTLAAY FQGQLLICLFVGTACFIGYLIAGLPYALILGIVMAITNIIPYVGPFLGAAPAVIVGFM DSPAKALFAIIVVVIVQQLDGNLLSPLVIGKRLNTHPLTIILLLIGAGSFGGILGMIL AVPVYAVVKAFFLNIVRLIKLRQRSRLEENAKPAE*" gene complement(3083118..3084227) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" promotor_-35 3083879..3083886 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3083901..3083920 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3083910..3084304 /Source="Nicolas_S_feature" /locus_tag="new_3263403_3263797" /HighExp="dia15, S8, H2O2, dia5, LBGstat, Paraq, C30, S7, Diami, G180" /AntisenseName="yueF" /AntisenseCor="0.28555063485711402" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1220" upshifts 3083910 /Source="Nicolas_upshifts" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" promotor_-10 complement(3084275..3084294) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-10" upshifts complement(3084291) /Source="Nicolas_upshifts" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" S_feature complement(3084293..3084733) /Source="Nicolas_S_feature" /locus_tag="new_3263786_3264226_c" /HighExp="Diami, S8, H2O2, S7, C90, Paraq, Salt, S1, dia15, dia5" /AntisenseName="yuzE" /AntisenseCor="0.47136608606324898" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1221" promotor_-35 3084296..3084298 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3084306 /Source="Nicolas_upshifts" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3084308..3084313) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-35" promotor_-10 3084314..3084333 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3084342..3084731 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391059.1" /db_xref="EnsemblGenomes-Gn:BSU31810" /db_xref="EnsemblGenomes-Tr:CAB15169" /db_xref="InterPro:IPR016789" /db_xref="InterPro:IPR019270" /db_xref="SubtiList:BG14054" /db_xref="UniProtKB/Swiss-Prot:O32096" /translation="MKAVTYDTDSELAYIYVLPPKKNRNVRTEELRVNDCLLLDISQD GKIAGFECFGEAAHLCAPFAGKSRLYVKDSDGYHFRVCQHASVRSCYTVYRVTFCFSD GDYQEFAGFDLDGTMYHSAFLQRLTEK*" gene 3084342..3084731 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" CDS complement(3084772..3085008) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391060.1" /db_xref="EnsemblGenomes-Gn:BSU31820" /db_xref="EnsemblGenomes-Tr:CAB15170" /db_xref="InterPro:IPR020139" /db_xref="SubtiList:BG14055" /db_xref="UniProtKB/Swiss-Prot:O32097" /translation="MVNQGSPQLVSLVDPYVYQTIKKLIGSRFVIQTVRDTVRGRLID VKPDHITIEGARNSVCLIRIQHMISVTPDYSERV*" gene complement(3084772..3085008) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" downshifts complement(3084778) /Source="Nicolas_upshifts" /id="D1646" /incds=0 /nref=12 /ntot=37 /MaxReadThrough="5.19136" /MaxDrop="5.1675" /score="30.7642328" /energy="-9.9" /TU="U2482" /idTUdmin="U2481" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3085028..3085047) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3085042) /Source="Nicolas_upshifts" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" S_feature complement(3085044..3085184) /Source="Nicolas_S_feature" /locus_tag="new_3264537_3264677_c" /HighExp="BT, Diami, S8, Etha, Sw, C90, Salt, B36, LPhT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.998, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1222" promotor_-35 complement(3085061..3085070) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3085185..3085715) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" /EC_number="3.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent phosphohydrolase" /protein_id="NP_391061.1" /db_xref="EnsemblGenomes-Gn:BSU31830" /db_xref="EnsemblGenomes-Tr:CAB15171" /db_xref="GOA:O32098" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="SubtiList:BG13960" /db_xref="UniProtKB/Swiss-Prot:O32098" /translation="MRKVTLMDVFTHPIAQKYLQRSGVAHAIACAYHAYRLSVKADIN PDLAAKAALLHDIGHYEWYTDGKWDYEKYKRNDIHAIKGAERAHKLLIRLGEEPKAAK EIALAILLHTDSYLPEGELDKNTLQQIVKKADELDEEPGGHHHYRQIDPSTARKKIEK LDQLIDQAQASVIKPV*" gene complement(3085185..3085715) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" promotor_-10 complement(3085735..3085754) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-10" upshifts complement(3085746) /Source="Nicolas_upshifts" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" S_feature complement(3085748..3085834) /Source="Nicolas_S_feature" /locus_tag="new_3265241_3265327_c" /HighExp="BT, S8, S6, S7, B36, Etha, S5, S4, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1223" promotor_-35 complement(3085766..3085774) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-35" promotor_-10 complement(3085829..3085848) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3085836) /Source="Nicolas_upshifts" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" promotor_-35 complement(3085862..3085871) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3085913..3086644) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" /EC_number="1.1.1.320" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11745140, 21670841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="benzil reductase (benzoin forming)" /protein_id="NP_391062.1" /db_xref="EnsemblGenomes-Gn:BSU31840" /db_xref="EnsemblGenomes-Tr:CAB15172" /db_xref="GOA:O32099" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13959" /db_xref="UniProtKB/Swiss-Prot:O32099" /translation="MELYIITGASKGLGQAIALQALEKGHEVHALSRTKTDVSHKKLT QHQIDLINLEEAEQQFETLLSSIDSDRYSGITLINNAGMVTPIKRAGEASLDELQRHY QLNLTAPVLLSQLFTKRFASYSGKKTVVNITSGAAKNPYKGWSAYCSSKAGLDMFTRT FGFEQEDEELPVNMISFSPGVMDTEMQAVIRSSSKKDFHHIERFRKLNETGSLRSPDF IAGTLLSLLEKGTENGRIYDIKEFL*" gene complement(3085913..3086644) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" downshifts complement(3085943) /Source="Nicolas_upshifts" /id="D1647" /incds=0 /nref=183 /ntot=253 /MaxReadThrough="2.76356" /MaxDrop="5.18507" /score="30.7642328" /energy="-9.9" /TU="NA" /idTUdmin="U2484" /TUdmin="-21" /isTUend="TRUE" promotor_-10 complement(3086659..3086678) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3086670) /Source="Nicolas_upshifts" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" promotor_-35 complement(3086693..3086700) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3086707..3087162) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YueC protein" /protein_id="NP_391063.1" /db_xref="EnsemblGenomes-Gn:BSU31850" /db_xref="EnsemblGenomes-Tr:CAB15173" /db_xref="GOA:O32100" /db_xref="InterPro:IPR018920" /db_xref="InterPro:IPR020212" /db_xref="SubtiList:BG13958" /db_xref="UniProtKB/Swiss-Prot:O32100" /translation="MLSFSLFIPSAAAAQTEENTDVAPNQYEKKDIEIDTNYLHEDTY YEEKTELPEEQKDITFDKPKDKDAELIKDLFTSTNAEDSNTIAAQSKQLGITFAEKPM TKTSSTETEDEQETSSLLLPMIYVVLILLGIAGIVFLIPKVTAQENKKA*" gene complement(3086707..3087162) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" promotor_-35 3087115..3087121 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3087136..3087154 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3087144..3089511 /Source="Nicolas_S_feature" /locus_tag="new_3266637_3269004" /HighExp="Etha, Gly, Sw, Salt, LoTm, C30, BT, HiTm, Mal, G135" /AntisenseName="yueB" /AntisenseCor="-9.3455707286730305E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1224" upshifts 3087144 /Source="Nicolas_upshifts" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" CDS complement(3087194..3090424) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022, 27179995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022, 27179995; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system; calcium-dependent phage SPP1 attachment site" /protein_id="NP_391064.1" /db_xref="EnsemblGenomes-Gn:BSU31860" /db_xref="EnsemblGenomes-Tr:CAB15174" /db_xref="GOA:O32101" /db_xref="InterPro:IPR023838" /db_xref="SubtiList:BG13957" /db_xref="UniProtKB/Swiss-Prot:O32101" /translation="MTEQRKSLIKLISAVIIILLLPVLFFRFIGDDPTKKAVNSTRQI AVVNEDTGVLSDEVKSDEEDKSAQFGKEVAAVLGERPDYSWTVVNRSAAETGLASKKY DAIVYIPSDFSKNILSYDKDHPQKATLEFSIQDNLNAVNKEKVQRELEDAQKTMNKKM SALYWNFVSQKVDNIRGEFDKIVNKESEFQNVMYNFYKPSSNDLAGEIKQQKDLIDEL KKSMNEAQGTTKEKASTAEEAKNTLKEFIDTVERYKEYQENQKKLLLAAQDSTQQQIR TGLDAIQAQQKANQFSERMSGLATGIGQAKTQIGLTNLALNNAEKLRQNQVPLQEMGM KKIENDMFNAFLSRYKSQYEAIKYQNLNQLQENIGKNRLSLLKPKESDEKEDGEDTSD NKDDTDKEDIEDIKLDLEKQRDELKNVATEIKDISEGLKEPEQEKPTTPDAEEPSTDD SPNTEEPSNDIPTSDDQPTNEDTGSSEEGTQDNGSQNDVQTNIETGQKHQESSKNVPE QDTNTENTGTSKTDFSLIELADENDGSNQSDGLQGDGADGETDISGAKKRLNEAAIKL EEIENALQEKQEEHNNKLEKHIDELNQEIKELNKTVSKLNDQIGDLTKKLVDFDNNVN DAYRLIYNLEDEIIQTLQSRGYIDQKEKLSSIFSSRIETDNISNLMKYYNSLNLYKST LNDNLDLGSLTIIKGEVIQEQDGNVQSVLALTPEESASWEALKNNTMQTDEDINSFID GMTKFADDYSGYIRDSQAGVLDELTKISESAAKASEQLVTGATQESATFSNDGLSGTM ALSVQDTVGQEVLQMSDMMGSLSDRQSGIIDYTTNMQQSVNDVQAKADTLNNNWGKNV ASTKLVRNDVYGILGNTLVDGQNNGYVYDYLANPLKISGEVPEEKIQTVPPVVILVIV LISSLLIGYFSSYYQNAPLLVKGALFGILNILVGLMISLFGLNIYSLPDDQTIKWSVF TILLLVASSAFIRTAFRFGSIPGWVASAAMILFYVAPLIDLIMPNFTFEDPVSKVYID IQYGTGHLFTMGITVLLIITVIAVALPLIIRLMAEHTAESDETYEA*" gene complement(3087194..3090424) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" CDS complement(3090421..3094908) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system FtsK/SpoIIIE family ATPase" /protein_id="NP_391066.2" /db_xref="EnsemblGenomes-Gn:BSU31875" /db_xref="EnsemblGenomes-Tr:CAB15176" /db_xref="GOA:C0SPA7" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR022206" /db_xref="InterPro:IPR023839" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12375" /db_xref="UniProtKB/Swiss-Prot:C0SPA7" /translation="MSLLWVFYQNNVQKLNLSNLPSSHPVTIGPDVKDSVTISTIPFN SGVISLKRKESGGQYEVFLGNDCLGTIETDISFTLQTDQQDIRLILTGSEPEKSVYFT GNRDEIVCSSEKTNADIYLNPQDFAFAEQSTFSLLRAGGSWSVRPESGTIFLNGEKIN ANTPLKPGDEIFWNFTQMRVTEQDLLEIVHYAQFETALTETVKPSTEMQKKYPQYRRT PRMVYDLPDDRVSFSFPSQESDQTNRGLWLVILPPLVMLIVMGVVAIIQPRGIFILVS LAMFMMTLITSTVQYFRDKNQRKKREEKRERVYKLYLDNKRKELQALAEKQKQVLEFH FPSFEQMKYLTSEISDRIWEKSLESKDYLQLRLGTGTVPSSYEINMSGGDLANRDIDD LMEKSQHMQRVYKDIRNAPVTVDLAEGPMGLVGKSQIVKNEIHQLIGQLSFFNSYHDL RFVFIFHEEEYKDWEWMKWLPQFQMPHIYAKGFIYNEQTRDQLLSSLYELIRERDLED DKEKLQFKPHFVFVITNQQLISEHVILEYLEGQHEHLGISTIVAAETKESLSENITTL VRYINEHEGDILIQKKKAVRIPFRLDHHQREDNERFSRTLRTLNHQVGITNSIPETVS FLELFHAKEVKEIGIQQRWLTSESSKSLSVPIGYKGKDDIVYLNLHEKAHGPHGLLAG TTGSGKSEFLQTYILSLAVHFHPHEAAFLLIDYKGGGMAQPFRNIPHLLGTITNIEGS KNFSMRALASIKSELKKRQRLFDQYQVNHINDYTKLYKQGKAEVAMPHLFLISDEFAE LKSEEPDFIRELVSAARIGRSLGVHLILATQKPGGIIDDQIWSNSRFKVALKVQDATD SKEILKNSDAANITVTGRGYLQVGNNEVYELFQSAWSGAPYLEEVYGTEDEIAIVTDT GLIPLSEVDTEDNAKKDVQTEIEAVVDEIERIQDEMGIEKLPSPWLPPLAERIPRTLF PSNEKDHFHFAYVDEPDLQRQAPIAYKMMEDGNIGIFGSSGYGKSIAAATFLMSFADV YTPEELHVYIFDFGNGTLLPLAKLPHTADYFLMDQSRKIEKFMIRIKEEIDRRKRLFR EKEISHIKMYNALSEEELPFIFITIDNFDIVKDEMHELESEFVQLSRDGQSLGIYFML TATRVNAVRQSLLNNLKTKIVHYLMDQSEGYSIYGRPKFNLEPIPGRVIIQKEELYFA QMFLPVDADDDIGMFNELKSDVQKLQGRFASMEQPAPIPMLPESLSTRELSIRFKLER KPLSVPIGLHEETVSPVYFDLGKHKHCLILGQTQRGKTNVLKVMLEHLIDDETEMIGL FDSIDRGLSHYAKESDVSYLETKEDIEQWIETAEDIFKTREAMYVEAVRQGDAQNLRF SQVVLMIDGITRFQQTIDTRIQDRLANFMKSYAHLGFSFIPGGNHSEFSKGYDSLTTE MKQIRHAILLMKKSEQNVIPLPYQRQEPEIQPGFGYVVENGKEQKVQIPLCSAERESA R*" gene complement(3090421..3094908) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" promotor_-35 3094183..3094189 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3094204..3094222 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3094210..3095172 /Source="Nicolas_S_feature" /locus_tag="new_3273703_3274665" /HighExp="Etha, Sw, Gly, Salt, B60, M9-stat, LoTm, T0.30H, BT, LPhT" /AntisenseName="yukB" /AntisenseCor="-0.26212584196591598" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1225" upshifts 3094210 /Source="Nicolas_upshifts" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" CDS complement(3094969..3096324) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" /function="11.1: Protein and peptide secretion and trafficking" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukC protein" /protein_id="NP_391067.1" /db_xref="EnsemblGenomes-Gn:BSU31890" /db_xref="EnsemblGenomes-Tr:CAB15177" /db_xref="GOA:P71070" /db_xref="InterPro:IPR018778" /db_xref="SubtiList:BG12376" /db_xref="UniProtKB/Swiss-Prot:P71070" /translation="MSGEQKSYLENQLEAVAEKTDAGYTFTFQREKIKLLDGLEANVI KDINPFFHKEIDVTDDEVIITIQPPSSYKAFRFMKAKDKKSKWQFAYQLVQAVQQHNL SRLNLIVAPENIVFDKGLTPYFLHYGVKESIPPYERDEERVWQELKAAAALAVDGAFA FEDYLKFNETLTFSAEAKAILDAESYDDLLELIQTHIDELEAKAKTYIHIPRKKWNIQ RYIGLGLIVLLVPALIYSMYALFFAQPKHQAIVDSNRAFLNKQYSEVISTLSKYDAES LPESVQYQLATSYVEVENLGSAKTKNIENNLVTLQSDPQHFLYWIDYGRGEYKEAISI GRKLEYNDYIYFALAKYKQQLLSEDTNDEDIQKELDSVNSELEKAQKERQENKQSNSE TSLVDTSEEQTQTDEEKQAEEKAAEEKAAAEEKAKKEEQKEKEDEKKETEKKDEKKDD K*" gene complement(3094969..3096324) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" downshifts complement(3094990) /Source="Nicolas_upshifts" /id="D1648" /incds=0 /nref=5 /ntot=116 /MaxReadThrough="6.33518" /MaxDrop="3.1562" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=5823 /isTUend="FALSE" CDS complement(3096339..3096578) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" /function="11.1: Protein and peptide secretion and trafficking" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukD protein" /protein_id="NP_391068.1" /db_xref="EnsemblGenomes-Gn:BSU31900" /db_xref="EnsemblGenomes-Tr:CAB15178" /db_xref="InterPro:IPR014921" /db_xref="InterPro:IPR024962" /db_xref="InterPro:IPR029071" /db_xref="PDB:2BPS" /db_xref="SubtiList:BG12377" /db_xref="UniProtKB/Swiss-Prot:P71071" /translation="MYIDITIDLKHYNGSVFDLRLSDYHPVKKVIDIAWQAQSVSMPP REGHWIRVVNKDKVFSGECKLSDCGITNGDRLEIL*" gene complement(3096339..3096578) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" CDS complement(3096648..3096941) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:11973144, 15576783, 22720735, 24798022, 24828531" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11973144, 15576783, 22720735, 24798022, 24828531; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small WGX100 secreted protein (ESX-dependent secretion)" /protein_id="NP_391069.2" /db_xref="EnsemblGenomes-Gn:BSU31910" /db_xref="EnsemblGenomes-Tr:CAB15179" /db_xref="GOA:C0SP85" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12378" /db_xref="UniProtKB/Swiss-Prot:C0SP85" /translation="MAGLIRVTPEELRAMAKQYGVESQEVLNQVDRLNRMISDLKSMW EGASSEAFADQYEQLKPSFIKMSDLLQDVNQQLDQTANTLESTDQDIANQIRG*" gene complement(3096648..3096941) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" downshifts complement(3096658) /Source="Nicolas_upshifts" /id="D1649" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="6.21938" /MaxDrop="7.50121" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=4155 /isTUend="FALSE" downshifts 3096935 /Source="Nicolas_upshifts" /id="D1650" /incds=0 /nref=1 /ntot=26 /MaxReadThrough="2.85718" /MaxDrop="3.33739" /score="43.0917981" /energy="-17.1" /TU="NA" /idTUdmin="U2487" /TUdmin="-242" /isTUend="FALSE" S_feature complement(3096942..3097020) /Source="Nicolas_S_feature" /locus_tag="new_3276435_3276513_c" /HighExp="T-1.10H, T1.0H, T-0.40H, T1.30H, BI, T2.30H, T3.0H, T-2.40H, T2.0H, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1226" promotor_-35 3096983..3096990 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3097000..3097019) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3097001 /Source="Nicolas_upshifts" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" promotor_-10 3097005..3097022 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3097020) /Source="Nicolas_upshifts" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" promotor_-35 complement(3097034..3097041) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3097079..3097084 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3097099..3097118 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3097111..3097217 /Source="Nicolas_S_feature" /locus_tag="new_3276604_3276710" /HighExp="S8, C30, S7, S6, Pyr, Glucon, B60, LoTm, C90, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="0.523, 0.76" /TUlongSig="NA" /TUlongPSig="NA" /label="S1227" upshifts 3097111 /Source="Nicolas_upshifts" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" promotor_-35 3097286..3097292 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3097306..3097325 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3097309 /Source="Nicolas_upshifts" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 3097414..3097417 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-35" upshifts 3097426 /Source="Nicolas_upshifts" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" promotor_-10 complement(3097429..3097448) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 3097433..3097452 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-10" upshifts complement(3097451) /Source="Nicolas_upshifts" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 3097462..3098730 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22797752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22797752; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AdeR-alanine)" /protein_id="NP_391070.2" /db_xref="EnsemblGenomes-Gn:BSU31920" /db_xref="EnsemblGenomes-Tr:CAB15180" /db_xref="GOA:P71073" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12379" /db_xref="UniProtKB/Swiss-Prot:P71073" /translation="MSKRNQARKVGRFMTMPNDPFKYSFDRLEDVADHISDVLRCPIT IEDVNHKLLAYSTHSDCTDPARTSTIIGRRVPEKVINKLWKDGTIPALLKTDQPIRVK QIDEVGLSNRVAISIWKNKQVLGFIWALEIQKTLSDEDLLTLQMAAKAVKNKLLKLQI RKTKNEERSQEFFWKMLTGHIHQEDDMADGFHKLGMAAPSEFSVMIIRINGELTEKIE QQLQYLQETTQQVYVLLATVDSNELIILTSPKTDHPFQDLKQFALSTQKQLKERYKIE DVSIAFGGIYNSISFVSRSYQEALSVLKTKERFAEETKHLFSFSELGIYQYLDVLNEK RKQAGHYNYSLSKLEQYDRDHQSNMVETLERFIEADSNVNTASKLLNIHVNTLNYRLK RISQIAEIDLKNVNQKFTIYLDIKLRHMDL*" gene 3097462..3098730 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" promotor_-35 complement(3097463..3097470) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3098790..3098809 /Source="Nicolas_upshift_promotors" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3098795 /Source="Nicolas_upshifts" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" CDS 3098832..3099968 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" /EC_number="1.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:488097, 8226620, 22720735, 22797752, 26202482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 488097, 8226620, 22720735, 22797752, 26202482; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-alanine dehydrogenase (NAD-dependent)" /protein_id="NP_391071.1" /db_xref="EnsemblGenomes-Gn:BSU31930" /db_xref="EnsemblGenomes-Tr:CAB15181" /db_xref="GOA:Q08352" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR007886" /db_xref="InterPro:IPR008141" /db_xref="InterPro:IPR008142" /db_xref="InterPro:IPR008143" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10468" /db_xref="UniProtKB/Swiss-Prot:Q08352" /translation="MIIGVPKEIKNNENRVALTPGGVSQLISNGHRVLVETGAGLGSG FENEAYESAGAEIIADPKQVWDAEMVMKVKEPLPEEYVYFRKGLVLFTYLHLAAEPEL AQALKDKGVTAIAYETVSEGRTLPLLTPMSEVAGRMAAQIGAQFLEKPKGGKGILLAG VPGVSRGKVTIIGGGVVGTNAAKMAVGLGADVTIIDLNADRLRQLDDIFGHQIKTLIS NPVNIADAVAEADLLICAVLIPGAKAPTLVTEEMVKQMKPGSVIVDVAIDQGGIVETV DHITTHDQPTYEKHGVVHYAVANMPGAVPRTSTIALTNVTVPYALQIANKGAVKALAD NTALRAGLNTANGHVTYEAVARDLGYEYVPAEKALQDESSVAGA*" gene 3098832..3099968 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" downshifts 3099968 /Source="Nicolas_upshifts" /id="D1651" /incds=0 /nref=42 /ntot=190 /MaxReadThrough="5.86626" /MaxDrop="4.4689" /score="41.2794059" /energy="-14.2" /TU="U2493" /idTUdmin="U2493" /TUdmin="-769" /isTUend="FALSE" promotor_-35 3100017..3100025 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3100035 /Source="Nicolas_upshifts" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" promotor_-10 3100037..3100055 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3100080..3100757 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391073.2" /db_xref="EnsemblGenomes-Gn:BSU31945" /db_xref="EnsemblGenomes-Tr:CAB15183" /db_xref="InterPro:IPR019268" /db_xref="SubtiList:BG12380" /db_xref="UniProtKB/Swiss-Prot:C0SPB1" /translation="MAVQQYGVLKGIVLDMKRETDDDSPHFQVKMLGEENTYYRCAIN VMSSSEESEVLYLADDQFDSGSITILPNMPYGYTRINEANREVALDYVRGNLFDPREM KPLPHEITGPDNDLNDFIETYMKKAQDEKTPVYIFGSKFGPEQAADKIFGFTPTNGMH NIHMNQGNAMDTRWKKDNGSWHDGGILIQFADQWAAVFLAFLSQSWCTDENGNPVRDC DHTQTSA*" gene 3100080..3100757 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" downshifts 3100741 /Source="Nicolas_upshifts" /id="D1652" /incds=0 /nref=37 /ntot=185 /MaxReadThrough="3.39608" /MaxDrop="5.40829" /score="9.49891506" /energy="-12" /TU="U2494" /idTUdmin="U2493" /TUdmin=4 /isTUend="TRUE" CDS complement(3100801..3101010) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11112781, 20845982, 21890635, 24975514, 28880538; Product type r: regulator" /codon_start=1 /transl_table=11 /product="stimulator of DhbF tyrosine adenylation activity" /protein_id="YP_003097779.1" /db_xref="EnsemblGenomes-Gn:BSU31959" /db_xref="EnsemblGenomes-Tr:CAX52685" /db_xref="InterPro:IPR005153" /db_xref="UniProtKB/Swiss-Prot:C0H3Q6" /translation="MANPFENADGTYLVLVNEEGQYSLWPGFIDVPSGWTVVHEQKGR EACLDYIQSHWSDMRPNSLKTVENV*" gene complement(3100801..3101010) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" downshifts complement(3100813) /Source="Nicolas_upshifts" /id="D1653" /incds=0 /nref=106 /ntot=174 /MaxReadThrough="1.39981" /MaxDrop="6.23998" /score="17.380299" /energy="-12" /TU="NA" /idTUdmin="U2496" /TUdmin=0 /isTUend="TRUE" CDS complement(3101026..3108162) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" /EC_number="2.7.7.-" /EC_number="5.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11112781, 12354229, 16672620, 18957859, 26284661, 27731335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11112781, 12354229, 16672620, 18957859, 26284661, 27731335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="siderophore 2,3-dihydroxybenzoate-glycine-threonine trimeric ester bacillibactin synthetase" /protein_id="NP_391076.3" /db_xref="EnsemblGenomes-Gn:BSU31960" /db_xref="EnsemblGenomes-Tr:CAB15186" /db_xref="GOA:P45745" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020802" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11243" /db_xref="UniProtKB/Swiss-Prot:P45745" /translation="MPDTKDLQYSLTGAQTGIWFAQQLDPDNPIYNTAEYIEINGPVN IALFEEALRHVIKEAESLHVRFGENMDGPWQMINPSPDVQLHVIDVSSEPDPEKTALN WMKADLAKPVDLGYAPLFNEALFIAGPDRFFWYQRIHHIAIDGFGFSLIAQRVASTYT ALIKGQTAKSRSFGSLQAILEEDTDYRGSEQYEKDRQFWLDRFADAPEVVSLADRAPR TSNSFLRHTAYLPPSDVNALKEAARYFSGSWHEVMIAVSAVYVHRMTGSEDVVLGLPM MGRIGSASLNVPAMVMNLLPLRLTVSSSMSFSELIQQISREIRSIRRHHKYRHEELRR DLKLIGENHRLFGPQINLMPFDYGLDFAGVRGTTHNLSAGPVDDLSINVYDRTDGSGL RIDVDANPEVYSESDIKLHQQRILQLLQTASAGEDMLIGQMELLLPEEKEKVISKWNE TAKSEKLVSLQDMFEKQAVLTPERIALMCDDIQVNYRKLNEEANRLARLLIEKGIGPE QFVALALPRSPEMVASMLGVLKTGAAYLPLDPEFPADRISYMLEDAKPSCIITTEEIA ASLPDDLAVPELVLDQAVTQEIIKRYSPENQDVSVSLDHPAYIIYTSGSTGRPKGVVV TQKSLSNFLLSMQEAFSLGEEDRLLAVTTVAFDISALELYLPLISGAQIVIAKKETIR EPQALAQMIENFDINIMQATPTLWHALVTSEPEKLRGLRVLVGGEALPSGLLQELQDL HCSVTNLYGPTETTIWSAAAFLEEGLKGVPPIGKPIWNTQVYVLDNGLQPVPPGVVGE LYIAGTGLARGYFHRPDLTAERFVADPYGPPGTRMYRTGDQARWRADGSLDYIGRADH QIKIRGFRIELGEIDAVLANHPHIEQAAVVVREDQPGDKRLAAYVVADAAIDTAELRR YMGASLPDYMVPSAFVEMDELPLTPNGKLDRKALPAPDFSTSVSDRAPRTPQEEILCD LFAEVLGLARVGIDDSFFELGGHSLLAARLMSRIREVMGAELGIAKLFDEPTVAGLAA HLDLAQSACPALQRAERPEKIPLSFAQRRLWFLHCLEGPSPTYNIPVAVRLSGELDQG LLKAALYDLVCRHESLRTIFPESQGTSYQHILDADRACPELHVTEIAEKELSDRLAEA VRYSFDLAAEPAFRAELFVIGPDEYVLLLLVHHIVGDGWSLTPLTRDLGTAYAARCHG RSPEWAPLAVQYADYALWQQELLGNEDDPNSLIAGQLAFWKETLKNLPDQLELPTDYS RPAEPSHDGDTIHFRIEPEFHKRLQELARANRVSLFMVLQSGLAALLTRLGAGTDIPI GSPIAGRNDDALGDLVGLFINTLVLRTDTSGDPSFRELLDRVREVNLAAYDNQDLPFE RLVEVLNPARSRATHPLFQIMLAFQNTPDAELHLPDMESSLRINSVGSAKFDLTLEIS EDRLADGTPNGMEGLLEYSTDLFKRETAQALADRLMRLLEAAESDPDEQIGNLDILAP EEHSSMVTDWQSVSEKIPHACLPEQFEKQAALRPDAIAVVYENQELSYAELNERANRL ARMMISEGVGPEQFVALALPRSLEMAVGLLAVLKAGAAYLPLDPDYPADRIAFMLKDA QPAFIMTNTKAANHIPPVENVPKIVLDDPELAEKLNTYPAGNPKNKDRTQPLSPLNTA YVIYTSGSTGVPKGVMIPHQNVTRLFAATEHWFRFSSGDIWTMFHSYAFDFSVWEIWG PLLHGGRLVIVPHHVSRSPEAFLRLLVKEGVTVLNQTPSAFYQFMQAEREQPDLGQAL SLRYVIFGGEALELSRLEDWYNRHPENRPQLINMYGITETTVHVSYIELDRSMAALRA NSLIGCGIPDLGVYVLDERLQPVPPGVAGELYVSGAGLARGYLGRPGLTSERFIADPF GPPGTRMYRTGDVARLRADGSLDYVGRADHQVKIRGFRIELGEIEAALVQHPQLEDAA VIVREDQPGDKRLAAYVIPSEETFDTAELRRYAAERLPDYMVPAAFVTMKELPLTPNG KLDRKALPAPDFAAAVTGRGPRTPQEEILCDLFMEVLHLPRVGIDDRFFDLGGHSLLA VQLMSRIREALGVELSIGNLFEAPTVAGLAERLEMGSSQSALDVLLPLRTSGDKPPLF CVHPAGGLSWCYAGLMTNIGTDYPIYGLQARGIGQREELPKTLDDMAADYIKQIRTVQ PKGPYHLLGWSLGGNVVQAMATQLQNQGEEVSLLVMLDAYPNHFLPIKEAPDDEEALI ALLALGGYDPDSLGEKPLDFEAAIEILRRDGSALASLDETVILNLKNTYVNSVGILGS YKPKTFRGNVLFFRSTIIPEWFDPIEPDSWKPYINGQIEQIDIDCRHKDLCQPEPLAQ IGKVLAVKLEELNK*" gene complement(3101026..3108162) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" CDS complement(3108182..3109120) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" /EC_number="3.3.2.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismatase (siderophore specific)" /protein_id="NP_391077.1" /db_xref="EnsemblGenomes-Gn:BSU31970" /db_xref="EnsemblGenomes-Tr:CAB15187" /db_xref="GOA:P45743" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11241" /db_xref="UniProtKB/Swiss-Prot:P45743" /translation="MAIPAIQPYQMPTASDMPQNKVSWVPDPNRAVLLIHDMQNYFVD AFTAGASPVTELSANIRKLKNQCVQLGIPVVYTAQPGSQNPDDRALLTDFWGPGLNSG PYEEKIITELAPEDDDLVLTKWRYSAFKRTNLLEMMRKEGRDQLIITGIYAHIGCLVT ACEAFMEDIKAFFVGDAVADFSLEKHQMALEYAAGRCAFTVMTDSLLDQLQNAPADVQ KTSANTGKKNVFTCENIRKQIAELLQETPEDITDQEDLLDRGLDSVRIMTLVEQWRRE GAEVTFVELAERPTIEEWQKLLTTRSQQVLPNADYL*" gene complement(3108182..3109120) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" CDS complement(3109148..3110767) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" /EC_number="2.7.7.58" /EC_number="6.3.2.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydroxybenzoate-AMP ligase" /protein_id="NP_391078.1" /db_xref="EnsemblGenomes-Gn:BSU31980" /db_xref="EnsemblGenomes-Tr:CAB15188" /db_xref="GOA:P40871" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR011963" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:1MD9" /db_xref="PDB:1MDB" /db_xref="PDB:1MDF" /db_xref="SubtiList:BG11020" /db_xref="UniProtKB/Swiss-Prot:P40871" /translation="MLKGFTPWPDELAETYRKNGCWAGETFGDLLRDRAAKYGDRIAI TCGNTHWSYRELDTRADRLAAGFQKLGIQQMDRVVVQLPNIKEFFEVIFALFRLGALP VFALPSHRSSEITYFCEFAEAAAYIIPDAYSGFDYRSLARQVQSKLPTLKNIIVAGEA EEFLPLEDLHAEPVKLPEVKSSDVAFLQLSGGSTGLSKLIPRTHDDYIYSLKRSVEVC WLDHSTVYLAALPMAHNYPLSSPGVLGVLYAGGRVVLSPSPSPDDAFPLIEREKVTIT ALVPPLAMVWMDAASSRRDDLSSLQVLQVGGAKFSAEAARRVKAVFGCTLQQVFGMAE GLVNYTRLDDPEEIIVNTQGKPMSPYDEMRVWDDHDRDVKPGETGHLLTRGPYTIRGY YKAEEHNAASFTEDGFYRTGDIVRLTRDGYIVVEGRAKDQINRGGEKVAAEEVENHLL AHPAVHDAAMVSMPDQFLGERSCVFIIPRDEAPKAAELKAFLRERGLAAYKIPDRVEF VESFPQTGVGKVSKKALREAISEKLLAGFKK*" gene complement(3109148..3110767) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" CDS complement(3110796..3111992) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" /EC_number="5.4.4.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12354229, 16672620, 19777807, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismate synthase (siderophore-specific)" /protein_id="NP_391079.2" /db_xref="EnsemblGenomes-Gn:BSU31990" /db_xref="EnsemblGenomes-Tr:CAB15189" /db_xref="GOA:P45744" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="SubtiList:BG11242" /db_xref="UniProtKB/Swiss-Prot:P45744" /translation="MLDQNVITETKAEHLLHEYQPGAFFLASPHRVLLAKGICEIVPE ADGQNQMETLSGRIAEALRQAKQSGQSRPLVVGAVPFDQVKAARLVVPEEVRWSGPLQ FDHEEKEQQAGHTYHIKPVPEPEDYKNGVEQGLARIADGTLSKIVLSRSLHLTSPEPI QTDELLRHLAQHNSHGYTFAADVSSQEETSPRRTLLGASPELLVSRMGTQVVSNPLAG SRPRSNDPVEDQRRAAELLSSAKDLHEHAVVADAVAAALRPFCRTLEVPEKPSLIKTE TMWHLSSVIKGELSDPSVTALELAAALHPTPAVCGTPTDLAREAILSIEPFDRGFFTG MVGWCDDAGDGEWIVTIRCAEAEERSLRLYAGAGVVAGSKPEDELQETSAKFRTMLRA MGVDHI*" gene complement(3110796..3111992) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" promotor_-35 3111840..3111847 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3111862..3111881 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3111869 /Source="Nicolas_upshifts" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3112018..3112803) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" /EC_number="1.3.1.28" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase" /protein_id="NP_391080.2" /db_xref="EnsemblGenomes-Gn:BSU32000" /db_xref="EnsemblGenomes-Tr:CAB15190" /db_xref="GOA:P39071" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR003560" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11019" /db_xref="UniProtKB/Swiss-Prot:P39071" /translation="MNAKGIEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEK LEKVVSSLKAEGRHAEAFPADVRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIH SLSDEEWEATFSVNSTGVFNASRSVSKYMMDRRSGSIVTVGSNAAGVPRTSMAAYASS KAAAVMFTKCLGLELAEYNIRCNIVSPGSTETDMQWSLWADENGAEQVIKGSLETFKT GIPLKKLAKPSDIADAVLFLVSGQAGHITMHNLCVDGGATLGV*" gene complement(3112018..3112803) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" S_feature complement(3112804..3112913) /Source="Nicolas_S_feature" /locus_tag="new_3292297_3292406_c" /HighExp="HiOs, GM 15, B60, nit, GM 10, GM 25, B36, GM 60, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1228" promotor_-10 complement(3112908..3112927) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3112913) /Source="Nicolas_upshifts" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" S_feature complement(3112915..3112996) /Source="Nicolas_S_feature" /locus_tag="new_3292408_3292489_c" /HighExp="HiOs, B60, nit, B36, GM 45, GM 10, BI, GM 15, GM 25, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1229" promotor_-35 complement(3112941..3112948) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3112997..3113866) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16889643, 19673474, 26284661, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillibactin trilactone hydrolase" /protein_id="NP_391081.2" /db_xref="EnsemblGenomes-Gn:BSU32010" /db_xref="EnsemblGenomes-Tr:CAB15191" /db_xref="GOA:O32102" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13974" /db_xref="UniProtKB/Swiss-Prot:O32102" /translation="MKEQTTDRTNGGTSNAFTIPGTEVRMMSSRNENRTYHIFISKPS TPPPPAGYPVIYLLDANSVFGTMTEAVRIQGRRPEKTGVIPAVIVGIGYETAEPFSSA RHRDFTMPTAQSKLPERPDGREWPEHGGAEGFFRFIEEDLKPEIERDYQIDKKRQTIF GHSLGGLFVLQVLLTKPDAFQTYIAGSPSIHWNKPFILKKTDHFVSLTKKNNQPINIL LAAGELEQHHKSRMNDNARELYERLAVLSEQGIRAEFCEFSGEGHISVLPVLVSRALR FALHPDGPHLSMG*" gene complement(3112997..3113866) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" S_feature complement(3113867..3113947) /Source="Nicolas_S_feature" /locus_tag="new_3293360_3293440_c" /HighExp="HiOs, B60, nit, GM 15, BI, B36, LoTm, T-5.40H, Lbexp, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1230" promotor_-10 complement(3113931..3113950) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3113947) /Source="Nicolas_upshifts" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" promotor_-35 complement(3113964..3113971) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3114080..3114676) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" /EC_number="1.7.3.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11598126, 16341843, 21190336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin containing enzyme subunit" /protein_id="NP_391082.1" /db_xref="EnsemblGenomes-Gn:BSU32020" /db_xref="EnsemblGenomes-Tr:CAB15192" /db_xref="GOA:O32103" /db_xref="InterPro:IPR000572" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13973" /db_xref="UniProtKB/Swiss-Prot:O32103" /translation="MYFGKTRQSDQSGRVPPNQNVTTSFPVLHTGDVPYYEDMTKWNL QVYGLVDHPMLLSFEDVKAFPRYESKNDIHCVTGWSRLDNVWQGVRACDIAEKAGVKE EAGYVILHAEEGWTTNLPLDDFLAETSLLAYAHNGEPLTPEHGFPLRGVFPHLYFWKS AKWLRGIQFTKENHPGFWERNGYHMRGDPWQNQRFTWD*" gene complement(3114080..3114676) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" S_feature complement(3114677..3114761) /Source="Nicolas_S_feature" /locus_tag="new_3294170_3294254_c" /HighExp="H2O2, Paraq, Cold, dia15, G135, B36, G180, B60, LoTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.204" /TUlongSig="NA" /TUlongPSig="NA" /label="S1231" promotor_-35 3114712..3114719 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3114729 /Source="Nicolas_upshifts" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" promotor_-10 3114734..3114753 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3114755..3114769) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3114761) /Source="Nicolas_upshifts" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" promotor_-35 complement(3114777..3114781) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3114777..3115379 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717296, 15849754, 16850406, 24816803; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative biotin transporter" /protein_id="NP_391083.1" /db_xref="EnsemblGenomes-Gn:BSU32030" /db_xref="EnsemblGenomes-Tr:CAB15193" /db_xref="GOA:O32104" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13972" /db_xref="UniProtKB/Swiss-Prot:O32104" /translation="MKQRKLRAGDMALIGMFAALMAVGANITSVAPFLQVAGIPLSMQ PFFCLLAALLLGSKRAAIAMIVYALVGLAGAPVFAQFSAGFAPFAGKSGGFIISYIPA AFAAGWFLERNIQPSKIRFLIASLIGTAIMYLIGTTYMYLALKLWIHTPVSYGTAWGF MIWFMVKDTALAVILSFIAPAIYRSIHKATGFNRNHISST*" gene 3114777..3115379 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" downshifts 3115365 /Source="Nicolas_upshifts" /id="D1654" /incds=0 /nref=145 /ntot=206 /MaxReadThrough="3.24182" /MaxDrop="6.72885" /score="12.6395055" /energy="-6.3" /TU="U2498" /idTUdmin="U2498" /TUdmin="-24" /isTUend="FALSE" CDS complement(3115449..3116777) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15135544, 15849754, 16850406, 23504016; Product type t : transporter" /codon_start=1 /transl_table=11 /product="histidine / basic amino acid transporter" /protein_id="NP_391084.1" /db_xref="EnsemblGenomes-Gn:BSU32040" /db_xref="EnsemblGenomes-Tr:CAB15194" /db_xref="GOA:O32105" /db_xref="InterPro:IPR018461" /db_xref="InterPro:IPR032813" /db_xref="SubtiList:BG13971" /db_xref="UniProtKB/Swiss-Prot:O32105" /translation="MNAVVIAVLLMLVLSLLRVNIVIALIIGALAGGLTGGLGLGETV KAFTDGLGGNATVAVSYAMLGAFAAALTKTGLPDAMVEASVKLIGNKEDSRKKALSKV LIVLIILIVSCFSQNVVPVHIAFIPVLIPPLLKIFNELEMDRRLIACVITFGLTAPYI LLPVGFGQIFQGMLKDNMADAGLNVPLADIPYALIIPVAGMVVGLILSVIVYRKPKQY ETKDISGAEASPYTRKSIGIAVLAIVVSLGVQLYLSQTLGVEGMIMGALAGLIVLFVS GVMKRDEADSLITDGMVLMAFIGFVMLVAAGFSNVLTKTGDVESLVKTSAGFIGHSQS LGALLMLIVGLLITMGIGSSFATIPVITTIFVPLCMQLGFSPMATIAIIGAAAALGDA GSPASDSTLGPTSGLSADGQHHHIWDTCVPTFIFYNIPLVIFGWIAALVL*" gene complement(3115449..3116777) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" downshifts complement(3115465) /Source="Nicolas_upshifts" /id="D1655" /incds=0 /nref=14 /ntot=114 /MaxReadThrough="4.26298" /MaxDrop="4.37949" /score="18.6861113" /energy="-15.4" /TU="U2500" /idTUdmin="U2500" /TUdmin="-66" /isTUend="FALSE" promotor_-10 complement(3116831..3116850) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3116834) /Source="Nicolas_upshifts" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" promotor_-35 complement(3116865..3116872) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3116924..3118426) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" /EC_number="3.4.11.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8057849, 9864319, 10449417, 26936797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytosol aminopeptidase" /protein_id="NP_391085.1" /db_xref="EnsemblGenomes-Gn:BSU32050" /db_xref="EnsemblGenomes-Tr:CAB15195" /db_xref="GOA:O32106" /db_xref="InterPro:IPR000819" /db_xref="InterPro:IPR008283" /db_xref="InterPro:IPR011356" /db_xref="InterPro:IPR023042" /db_xref="SubtiList:BG13970" /db_xref="UniProtKB/Swiss-Prot:O32106" /translation="MFYAVQQSEHTETLVVGLFQKSQLTGKALEIDEMLEGHLTQLLK EGDVSAKPNQVSKVFPPSSAGMKRIYFVGLGREANYSFEQAKERFAHVFQAIHKDRKQ ETAVLLDTFISEDVPPADAAHALAESCLLASYEVQDYKHKSNEPDKQIEAVYVVTDED TQEVQAGLRVGQAYGQGTNSARTLVNMPGNMLTATDLASYAEELAAKYDFECEILEKS EMEELGMGGILAVNQGSTEPPKMIVLKYQGKKEWEDVVGLVGKGITFDTGGYSIKTKS GIVGMKSDMGGAAAVLGAMETIGELRPEQNVLCVIPSTDNMISGGAMKPDDVIVSLSG KTIEILNTDAEGRLVLADGITYAKQHGASVLVDVATLTGGVVVALGTETTGAMTNDQS FYQQVADAAQECGEAIWQLPITEKDKKRVKSSQMADLSNSPGREGHAIMAGTFLGEFA ESTPWVHLDIAGTATANKATCFGPAGATGVMARTLATLAERFTLEEDKNE*" gene complement(3116924..3118426) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" downshifts complement(3116939) /Source="Nicolas_upshifts" /id="D1656" /incds=0 /nref=149 /ntot=220 /MaxReadThrough="4.44151" /MaxDrop="5.59726" /score="31.6277104" /energy="-16" /TU="NA" /idTUdmin="U2503" /TUdmin=0 /isTUend="TRUE" misc_feature 3117991..3118005 /Source="Nicolas_upshift_promotors" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3118007 /Source="Nicolas_upshifts" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(3118427..3118501) /Source="Nicolas_S_feature" /locus_tag="new_3297920_3297994_c" /HighExp="M40t90, Lbtran, LBGtran, Lbstat, C90, M0t90, T1.0H, LoTm, M40t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1232" promotor_-35 3118449..3118456 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3118467..3118486 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3118469..3118583 /Source="Nicolas_S_feature" /locus_tag="new_3297962_3298076" /HighExp="Etha, Cold, Gly, Sw, LoTm, BC, B60, C90, dia5, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1233" upshifts 3118469 /Source="Nicolas_upshifts" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" misc_feature complement(3118496..3118515) /Source="Nicolas_upshift_promotors" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3118506) /Source="Nicolas_upshifts" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" CDS 3118584..3119060 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391086.1" /db_xref="EnsemblGenomes-Gn:BSU32060" /db_xref="EnsemblGenomes-Tr:CAB15196" /db_xref="GOA:O32107" /db_xref="InterPro:IPR003832" /db_xref="SubtiList:BG13969" /db_xref="UniProtKB/Swiss-Prot:O32107" /translation="MELLTNFPLLSSLAAIIFAQVIKVPIQFIVSRKLDWSLVTSTGG MPSSHSAAVTALSTGVALEHGLDSSLFAVSAIFAVITMFDATGVRRHAGEQATVINKL VIDFNRFVNEAKDFPKAAEKEKQKKLKELLGHQPIEVFFGGLTGILLTLVLAYFFM*" gene 3118584..3119060 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" downshifts 3119009 /Source="Nicolas_upshifts" /id="D1657" /incds=0 /nref=18 /ntot=174 /MaxReadThrough="3.22946" /MaxDrop="3.90704" /score="10.9647804" /energy="-11.6" /TU="U2502" /idTUdmin="U2502" /TUdmin="-208" /isTUend="FALSE" CDS complement(3119091..3119747) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" /experiment="publication(s) with functional evidences, PMID:26163297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26163297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stationary phase survival protein" /protein_id="NP_391087.1" /db_xref="EnsemblGenomes-Gn:BSU32070" /db_xref="EnsemblGenomes-Tr:CAB15197" /db_xref="GOA:O32108" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR036908" /db_xref="PDB:4WJT" /db_xref="PDB:4WLI" /db_xref="PDB:4WLK" /db_xref="SubtiList:BG13968" /db_xref="UniProtKB/Swiss-Prot:O32108" /translation="MMLNMIRRLLMTCLFLLAFGTTFLSVSGIEAKDLSKWVQEHQEK HLKHAGLRLKALQQKQTQTTSAAEDKTKPLEEAFDWDEYPVQRVTATGYTAGAESTGK NPGDPLYGLTYSGVKVKRDLYSTVAADPSVFPIGTILFIPNYGLGVVADTGSAIKGNR LDLYFETVKDVYNEWGKKTLDVYVIKKGTGKITEDELEKLNETKSLQVFRNQYKTVKE *" gene complement(3119091..3119747) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" downshifts complement(3119119) /Source="Nicolas_upshifts" /id="D1658" /incds=0 /nref=178 /ntot=253 /MaxReadThrough="0.714039999999999" /MaxDrop="6.31907" /score="33.0538307" /energy="-12.6" /TU="NA" /idTUdmin="U2505" /TUdmin="-2" /isTUend="TRUE" promotor_-35 3119395..3119404 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3119418..3119437 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3119435 /Source="Nicolas_upshifts" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" S_feature 3119437..3119883 /Source="Nicolas_S_feature" /locus_tag="new_3298930_3299376" /HighExp="S6, S8, S7, BT, B36, G/S, S5, Pyr, Cold, B60" /AntisenseName="yuiC" /AntisenseCor="0.52395204592174105" /AntisenseRegPval="-19.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1234" upshifts complement(3119761) /Source="Nicolas_upshifts" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" promotor_-10 complement(3119763..3119774) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3119789..3119795) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3119840 /Source="Nicolas_upshifts" /id="D1659" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="7.61734" /MaxDrop="4.9382" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin="-323" /isTUend="FALSE" CDS complement(3119851..3120171) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391088.1" /db_xref="EnsemblGenomes-Gn:BSU32080" /db_xref="EnsemblGenomes-Tr:CAB15198" /db_xref="GOA:O32109" /db_xref="InterPro:IPR025917" /db_xref="SubtiList:BG13967" /db_xref="UniProtKB/Swiss-Prot:O32109" /translation="MISLPVVIISIVLFFVLFFGIGFLLNMLLRMSWIMAVIYPIVCL FIISKEKLISYVQSPGESFASLFHRVLSLAAADVLILVSGLAGAIVSGIAINMLRKRG YQMF*" gene complement(3119851..3120171) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" downshifts complement(3119865) /Source="Nicolas_upshifts" /id="D1660" /incds=0 /nref=151 /ntot=218 /MaxReadThrough="4.24535" /MaxDrop="5.6597" /score="13.4559443" /energy="-7.6" /TU="U2507,U2508" /idTUdmin="U2510" /TUdmin=660 /isTUend="FALSE" S_feature 3119885..3120095 /Source="Nicolas_S_feature" /locus_tag="new_3299378_3299588" /HighExp="S8, S6, S7, BT, Cold, Gly, H2O2, G/S, C30, G180" /AntisenseName="yuiB" /AntisenseCor="-0.11290507783715401" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1235" promotor_no_box 3120037..3120137 /Source="Nicolas_upshift_promotors" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 3120097..3120206 /Source="Nicolas_S_feature" /locus_tag="new_3299590_3299699" /HighExp="S8, S6, BT, S7, Sw, Gly, G180, BC, Diami, H2O2" /AntisenseName="yuiB" /AntisenseCor="-7.7565560595235006E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.03, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1236" upshifts 3120097 /Source="Nicolas_upshifts" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" downshifts 3120163 /Source="Nicolas_upshifts" /id="D1661" /incds=0 /nref=10 /ntot=28 /MaxReadThrough="3.79664" /MaxDrop="6.06021" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3120190..3120209) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3120195) /Source="Nicolas_upshifts" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" S_feature 3120208..3120759 /Source="Nicolas_S_feature" /locus_tag="new_3299701_3300252" /HighExp="S6, S8, S7, Cold, H2O2, BC, Sw, Pyr, BT, C30" /AntisenseName="yuiA" /AntisenseCor="5.87811391089679E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1237" promotor_-35 complement(3120224..3120231) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3120225..3120368) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391089.1" /db_xref="EnsemblGenomes-Gn:BSU32090" /db_xref="EnsemblGenomes-Tr:CAB15199" /db_xref="InterPro:IPR035272" /db_xref="InterPro:IPR036410" /db_xref="SubtiList:BG12389" /db_xref="UniProtKB/Swiss-Prot:O32110" /translation="MKTATTTASHACPFCSGKGYFQLILGGSETCPSCQGTGKDSHSF SSR*" gene complement(3120225..3120368) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" promotor_-10 complement(3120392..3120411) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3120413) /Source="Nicolas_upshifts" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" promotor_-35 complement(3120427..3120430) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3120541..3121761) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 17015645, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-disulfide oxidoreductase" /protein_id="NP_391090.1" /db_xref="EnsemblGenomes-Gn:BSU32100" /db_xref="EnsemblGenomes-Tr:CAB15200" /db_xref="GOA:O05267" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12390" /db_xref="UniProtKB/Swiss-Prot:O05267" /translation="MALNKPKIVILGAGYGGLMTVTRLTKYVGPNDADITLVNKHNYH YETTWMHEASAGTLHHDRCRYQIKDVINQSRVNFVQDTVKAIKIDEKKVVLANGELQY DYLVIGLGAVPETFGIKGLKEYAFPIANINTSRLLREHIELQFATYNTEAEKRPDRLT IVVGGAGFTGIEFLGELAARVPELCKEYDVDRSLVRIICVEAAPTVLPGFDPELVDYA VHYLEENGVEFKIGTAVQECTPEGVRVGKKDEEPEQIKSQTVVWAAGVRGHPIVEEAG FENMRGRVKVNPDLRAPGHDNVFILGDSSLFMNEDTERPYPPTAQIAMQQGITVAKNL GRLIKGGELEEFKPDIKGTVASLGEHNAVGVVYGRKLKGTPASFMKKVIDNRSLFMIG GLGLTLKKGKFKFF*" gene complement(3120541..3121761) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" downshifts complement(3120569) /Source="Nicolas_upshifts" /id="D1662" /incds=0 /nref=15 /ntot=123 /MaxReadThrough="3.19525" /MaxDrop="3.6794" /score="23.523765" /energy="-8.9" /TU="U2510" /idTUdmin="U2509" /TUdmin=0 /isTUend="TRUE" S_feature complement(3121762..3121889) /Source="Nicolas_S_feature" /locus_tag="new_3301255_3301382_c" /HighExp="Salt, S4, Etha, S5, S3, S7, S6, LoTm, B36, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.752, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1238" upshifts complement(3121889) /Source="Nicolas_upshifts" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" S_feature complement(3121891..3121955) /Source="Nicolas_S_feature" /locus_tag="new_3301384_3301448_c" /HighExp="Salt, Etha, Heat, BMM, BC, H2O2, Paraq, C30, Sw, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1239" promotor_-10 complement(3121891..3121909) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3121925..3121930) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3121946..3121965) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3121954) /Source="Nicolas_upshifts" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" promotor_-35 complement(3121980..3121987) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3122029..3122036 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3122048..3122067 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3122048 /Source="Nicolas_upshifts" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" CDS 3122093..3123091 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" /EC_number="1.18.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15252706, 22938038, 26507228, 26965753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 22938038, 26507228, 26965753; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferredoxin-NADP+ reductase (flavodoxin)" /protein_id="NP_391091.2" /db_xref="EnsemblGenomes-Gn:BSU32110" /db_xref="EnsemblGenomes-Tr:CAB15201" /db_xref="GOA:O05268" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="PDB:3LZW" /db_xref="PDB:3LZX" /db_xref="SubtiList:BG12391" /db_xref="UniProtKB/Swiss-Prot:O05268" /translation="MREDTKVYDITIIGGGPVGLFTAFYGGMRQASVKIIESLPQLGG QLSALYPEKYIYDVAGFPKIRAQELINNLKEQMAKFDQTICLEQAVESVEKQADGVFK LVTNEETHYSKTVIITAGNGAFKPRKLELENAEQYEGKNLHYFVDDLQKFAGRRVAIL GGGDSAVDWALMLEPIAKEVSIIHRRDKFRAHEHSVENLHASKVNVLTPFVPAELIGE DKIEQLVLEEVKGDRKEILEIDDLIVNYGFVSSLGPIKNWGLDIEKNSIVVKSTMETN IEGFFAAGDICTYEGKVNLIASGFGEAPTAVNNAKAYMDPKARVQPLHSTSLFENK*" gene 3122093..3123091 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" promotor_-10 complement(3122116..3122134) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3122131) /Source="Nicolas_upshifts" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3122151..3122156) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3123067 /Source="Nicolas_upshifts" /id="D1663" /incds=0 /nref=162 /ntot=262 /MaxReadThrough="0.70088" /MaxDrop="7.47867" /score="21.6819221" /energy="-12.8" /TU="U2511" /idTUdmin="U2511" /TUdmin="-22" /isTUend="TRUE" CDS complement(3123130..3123270) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein or unknown function" /protein_id="NP_391092.1" /db_xref="EnsemblGenomes-Gn:BSU32120" /db_xref="EnsemblGenomes-Tr:CAB15202" /db_xref="GOA:O32111" /db_xref="SubtiList:BG14056" /db_xref="UniProtKB/Swiss-Prot:O32111" /translation="MAQNEEKTPKSQKIQDRIIMAMIWVVAALVIALVVGTALNYINI FK*" gene complement(3123130..3123270) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" downshifts complement(3123142) /Source="Nicolas_upshifts" /id="D1664" /incds=0 /nref=61 /ntot=234 /MaxReadThrough="1.27572" /MaxDrop="5.65243" /score="32.0354025" /energy="-12.8" /TU="NA" /idTUdmin="U2515" /TUdmin=1 /isTUend="TRUE" S_feature complement(3123271..3123400) /Source="Nicolas_S_feature" /locus_tag="new_3302764_3302893_c" /HighExp="dia15, Salt, Cold, Diami, H2O2, Etha, GM 15, dia5, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.36371900000000001" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1240" promotor_-10 complement(3123381..3123400) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3123400) /Source="Nicolas_upshifts" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" S_feature complement(3123402..3123649) /Source="Nicolas_S_feature" /locus_tag="new_3302895_3303142_c" /HighExp="S8, S5, S6, S7, S4, ferm, nit, C30, Pyr, T5.0H" /AntisenseName="guaC" /AntisenseCor="-0.291283195124732" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1241" promotor_-35 complement(3123414..3123420) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3123457..3123464 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3123478..3123497 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3123486 /Source="Nicolas_upshifts" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" CDS 3123549..3124529 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" /EC_number="1.7.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 11591660, 6408059" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 11591660, 6408059; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP reductase (NADP-dependent)" /protein_id="NP_391093.2" /db_xref="EnsemblGenomes-Gn:BSU32130" /db_xref="EnsemblGenomes-Tr:CAB15203" /db_xref="GOA:O05269" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005994" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG12392" /db_xref="UniProtKB/Swiss-Prot:O05269" /translation="MENVFDYEDIQLIPAKCIVNSRSECDTSVRLGGHTFKLPVVPAN MQTIIDEKLAISLAENGYFYVMHRFEPETRIDFIKDMNARGLFSSISVGVKDEEYEFV RQLAEENLTPEYVTIDIAHGHSNAVIEMIQHLKKHLPDSFVIAGNVGTPEAVRELENA GADATKVGIGPGKVCITKIKTGFGTGGWQLAALRWCAKAASKPIIADGGIRTHGDIAK SIRFGATMVMIGSLFAGHEESPGQTIEKDGKLYKEYFGSASEFQKGEKKNVEGKKMHV AHKGSIKDTLIEMEQDLQSSISYAGGTKLNAIRNVDYVIVKNSIFNGDKY*" gene 3123549..3124529 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" upshifts complement(3123650) /Source="Nicolas_upshifts" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" promotor_-10 complement(3123654..3123665) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3123679..3123685) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3124497 /Source="Nicolas_upshifts" /id="D1665" /incds=0 /nref=91 /ntot=186 /MaxReadThrough="1.24882" /MaxDrop="7.43286" /score="-2.82053244" /energy="-16.2" /TU="NA" /idTUdmin="U2514" /TUdmin=0 /isTUend="TRUE" downshifts complement(3124602) /Source="Nicolas_upshifts" /id="D1666" /incds=0 /nref=24 /ntot=212 /MaxReadThrough="1.15696" /MaxDrop="6.12198" /score="23.834956" /energy="-16.2" /TU="NA" /idTUdmin="U2517" /TUdmin="-7" /isTUend="TRUE" CDS complement(3124603..3125226) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16210326, 21633969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates paiA expression)" /protein_id="NP_391094.2" /db_xref="EnsemblGenomes-Gn:BSU32140" /db_xref="EnsemblGenomes-Tr:CAB15204" /db_xref="GOA:P21341" /db_xref="InterPro:IPR007396" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG10696" /db_xref="UniProtKB/Swiss-Prot:P21341" /translation="MYIPKYFKVTNAEEIWNFVQENSFGTVVTTEQGKPIATHLPLGF NKKDDHYYITGHFAYGNPQWRTFEACEDVLVMFQGPHAYISSSWYSRENVPTWNYQAV HMYGKASMLEKDELAEELTIMLEKYEKHRDNPVLWDKLSPKLLESELKGIVGFKIKVE DIQAAYKLSQNRNETDYMNVIEQLQNEENPNAKQMAELMEDKLKKQI*" gene complement(3124603..3125226) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" CDS complement(3125250..3125768) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" /EC_number="2.3.1.57" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16210326, 17588214, 21633970, 26818562, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16210326, 17588214, 21633970, 26818562, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyamine N-acetyltransferase" /protein_id="NP_391095.1" /db_xref="EnsemblGenomes-Gn:BSU32150" /db_xref="EnsemblGenomes-Tr:CAB15205" /db_xref="GOA:P21340" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1TIQ" /db_xref="SubtiList:BG10695" /db_xref="UniProtKB/Swiss-Prot:P21340" /translation="MSVKMKKCSREDLQTLQQLSIETFNDTFKEQNSPENMKAYLESA FNTEQLEKELSNMSSQFFFIYFDHEIAGYVKVNIDDAQSEEMGAESLEIERIYIKNSF QKHGLGKHLLNKAIEIALERNKKNIWLGVWEKNENAIAFYKKMGFVQTGAHSFYMGDE EQTDLIMAKTLI*" gene complement(3125250..3125768) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" misc_feature complement(3125815..3125834) /Source="Nicolas_upshift_promotors" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3125827) /Source="Nicolas_upshifts" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(3125829..3125937) /Source="Nicolas_S_feature" /locus_tag="new_3305322_3305430_c" /HighExp="LoTm, HiTm, G135, Salt, G180, Cold, LBGstat, T0.0H, B36, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1242" promotor_-10 complement(3125924..3125941) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3125935) /Source="Nicolas_upshifts" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" promotor_-35 complement(3125956..3125963) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3126091) /Source="Nicolas_upshifts" /id="D1667" /incds=0 /nref=267 /ntot=269 /MaxReadThrough="1.56881" /MaxDrop="8.24828" /score="12.6937405" /energy="-18.7" /TU="NA" /idTUdmin="U2518" /TUdmin=0 /isTUend="TRUE" CDS complement(3126106..3126468) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17698959, 19478995, 20097860, 25447545; Product type c: carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier chaperone involved in Fe-S cluster assembly" /protein_id="NP_391096.1" /db_xref="EnsemblGenomes-Gn:BSU32160" /db_xref="EnsemblGenomes-Tr:CAB15206" /db_xref="GOA:O32113" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR016092" /db_xref="InterPro:IPR017870" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG14049" /db_xref="UniProtKB/Swiss-Prot:O32113" /translation="MSNPVTITEAAALHIKDMMKEHEEENAFLRVGVKGGGCSGLSYG MGFEHEKSESDSVFDQHGITVLVDKESLDIMNGTVIDYKQSMLGGGFTIDNPNAIASC GCGSSFRTATNAGKPEEC*" gene complement(3126106..3126468) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" promotor_-10 complement(3126499..3126518) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3126509) /Source="Nicolas_upshifts" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" promotor_-35 complement(3126532..3126539) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3126547..3127401) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" /EC_number="5.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 14627808, 16723397, 19307721, 28873470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diaminopimelate epimerase" /protein_id="NP_391097.1" /db_xref="EnsemblGenomes-Gn:BSU32170" /db_xref="EnsemblGenomes-Tr:CAB15207" /db_xref="GOA:O32114" /db_xref="InterPro:IPR001653" /db_xref="InterPro:IPR018510" /db_xref="SubtiList:BG14048" /db_xref="UniProtKB/Swiss-Prot:O32114" /translation="MNSFRFTKMHGLGNSYIYVNQFEEQLPEEKLSEIAIQVSSVYTG IGSDGMILICPSDQAPVKMRIFNNDGSEGKNCGNGLRCVAKYAYEHKLVEETSFLIET LSGLVKAEVQVENGKVNVVTVDMGEPRLTKSELPMLDGGEEHTINETMAFGEVELTGT AVSMGNPHIVFPIADIEQAPLTTLGPVIEKDPRFPEGINVEFVETVNEQELHFRVWER GSGITQACGTGACAAAVASVLNGVSKRNQDITVHLAGGDLVINWKDNGHVMMTGPAET VCEGVYFL*" gene complement(3126547..3127401) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" promotor_-10 complement(3127117..3127136) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3127125) /Source="Nicolas_upshifts" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" promotor_-35 complement(3127149..3127158) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3127423..3127442) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3127437) /Source="Nicolas_upshifts" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" promotor_-35 complement(3127457..3127460) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3127524..3128738) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+(H+)/nucleoside cotransporter" /protein_id="NP_391098.1" /db_xref="EnsemblGenomes-Gn:BSU32180" /db_xref="EnsemblGenomes-Tr:CAB15208" /db_xref="GOA:O32115" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG14047" /db_xref="UniProtKB/Swiss-Prot:O32115" /translation="MNVLWGLLGAVAIIAIAFLFSEKKSNIKIRTVIVGLCTQVAFGY IVLKWEAGRAVFLWFSSRVQLLIDYANEGISFIFGPLLKVGDSPAFALSVLPVIIFFS ALIAVLYHLKIMQLVFRVIGGGLSKLLGTSKTESLAAAANIFVGQSESPLVIKPLIAG LTRSELFTIMTSGLSAVAGSTLFGYALLGIPIEYLLAASFMAAPAGLVFGKLIIPETE KTQTVKSDFKMDEGEGAANVIDAAAKGASTGLQIALNVGAMLLAFVALIAVVNGILGG AFGLFGLKGVTLESILGYVFSPIAFLIGVPWHEALQAGSYIGQKLVLNEFVAYSNFGS HIGEFSKKTATIISFALCGFANFSSIAIMLGTLGGLAPSRRSDIARLGLKAVLAGTLA NLLSAAIAGMFI*" gene complement(3127524..3128738) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" promotor_-35 3128073..3128079 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 3128094..3128112 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-10" upshifts 3128101 /Source="Nicolas_upshifts" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" S_feature 3128105..3128874 /Source="Nicolas_S_feature" /locus_tag="new_3307598_3308367" /HighExp="Etha, Salt, Gly, M9-stat, Sw, LoTm, B60, BC, Heat, S0" /AntisenseName="yutK" /AntisenseCor="-0.36240965013078302" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1243" promotor_-10 complement(3128775..3128794) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-10" upshifts complement(3128780) /Source="Nicolas_upshifts" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" promotor_-35 complement(3128809..3128816) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-35" downshifts 3128831 /Source="Nicolas_upshifts" /id="D1668" /incds=0 /nref=3 /ntot=58 /MaxReadThrough="4.13852" /MaxDrop="3.94079" /score="20.5760616" /energy="-10.5" /TU="U2521" /idTUdmin="U2521" /TUdmin="-1913" /isTUend="FALSE" CDS complement(3128875..3129111) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391099.1" /db_xref="EnsemblGenomes-Gn:BSU32190" /db_xref="EnsemblGenomes-Tr:CAB15209" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR022916" /db_xref="SubtiList:BG14051" /db_xref="UniProtKB/Swiss-Prot:O32116" /translation="MNPMIEFCVSNLAHGSQEARAILEKDPNLDVLEYGCLSYCGTCM ESLFALVNGEVVMGETPAELVENIYTFIEENPMF*" gene complement(3128875..3129111) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" S_feature 3128876..3129292 /Source="Nicolas_S_feature" /locus_tag="new_3308369_3308785" /HighExp="Salt, LoTm, Gly, Etha, Sw, Heat, S0, C30, M9-stat, Mal" /AntisenseName="yuzB" /AntisenseCor="-5.6824456709843603E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1244" downshifts complement(3128893) /Source="Nicolas_upshifts" /id="D1669" /incds=0 /nref=175 /ntot=239 /MaxReadThrough="1.28789" /MaxDrop="7.32368" /score="41.4640292" /energy="-10.5" /TU="NA" /idTUdmin="U2523" /TUdmin="-8" /isTUend="TRUE" promotor_-10 complement(3129076..3129077) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3129081..3129085) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3129083) /Source="Nicolas_upshifts" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" promotor_-10 complement(3129126..3129145) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3129127) /Source="Nicolas_upshifts" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" promotor_-35 complement(3129159..3129166) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3129269..3129274 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 3129288..3129307 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-10" upshifts 3129294 /Source="Nicolas_upshifts" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" CDS 3129374..3130441 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" /EC_number="1.6.-.-" /function="16.10: Respire" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17015645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH dehydrogenase" /protein_id="NP_391100.2" /db_xref="EnsemblGenomes-Gn:BSU32200" /db_xref="EnsemblGenomes-Tr:CAB15210" /db_xref="GOA:O32117" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14046" /db_xref="UniProtKB/Swiss-Prot:O32117" /translation="MKKLVLIGGGYGNMRVLHRLLPNQLPDDVSITLIDRNPYHCLKT EYYALAAGTISDHHIRVSFPEHPRLDVQYGDITSIDIVQKQVLFQDREPISYDDAIIG LGCEDKYHNVPGAPEFTYSIQTIDQSRETYQKLNNLSANATVAIVGAGLSGVELASEL RESRDDLNIILFDRGNLILSSFPERLSKYVQKWFEEHGVRIINRANITKVEEGVVYNH DDPISADAIVWTAGIQPNKVVRDLDVEKDAQGRIVLTPHHNLPGDEHLYVVGDCASLP HAPSAQLAEAQAEQIVQILQKRWNGEALPESMPQFKLKGVLGSLGKKAGFGLVADRPL IGRVPRMLKSGLLWMYKHHNG*" gene 3129374..3130441 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" downshifts 3130425 /Source="Nicolas_upshifts" /id="D1670" /incds=0 /nref=4 /ntot=110 /MaxReadThrough="3.51945" /MaxDrop="3.02708" /score="6.15657679" /energy="-10.8" /TU="U2521,U2525" /idTUdmin="U2521" /TUdmin="-319" /isTUend="FALSE" CDS complement(3130467..3130793) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11551182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reduction management enzyme" /protein_id="NP_391101.1" /db_xref="EnsemblGenomes-Gn:BSU32210" /db_xref="EnsemblGenomes-Tr:CAB15211" /db_xref="InterPro:IPR009190" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14053" /db_xref="UniProtKB/Swiss-Prot:O32118" /translation="MMKPVMLSVYGAENVCASCVNMPTAKDTYEWLEAALKRKYPNQP FEMQYIDIHEPPDNEHAKELAEKIRNDEYFYPLVLVEDKIVGEGNPKLKDVYEEMEKH GYTENR*" gene complement(3130467..3130793) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" downshifts complement(3130490) /Source="Nicolas_upshifts" /id="D1671" /incds=0 /nref=4 /ntot=180 /MaxReadThrough="1.63835" /MaxDrop="3.17377" /score="-8.05690984" /energy="-10.8" /TU="NA" /idTUdmin="U2526" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3130825..3130844) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3130842) /Source="Nicolas_upshifts" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" promotor_-35 complement(3130857..3130864) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3130877..3130881 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3130893..3131228 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17237162, 21749987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative iron-sulfur scaffold protein" /protein_id="NP_391102.1" /db_xref="EnsemblGenomes-Gn:BSU32220" /db_xref="EnsemblGenomes-Tr:CAB15212" /db_xref="GOA:O32119" /db_xref="InterPro:IPR001075" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG14045" /db_xref="UniProtKB/Swiss-Prot:O32119" /translation="MCYNRESNFANQTIDFYCYTEYNGFMTTKGANVMTEVEMKEQVQ EVLDKLRPFLLRDGGDCELVDVDEGIVKLRLLGACGSCPSSTITLKAGIERALLEEVP GVVEVEQVF*" gene 3130893..3131228 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" promotor_-10 3130894..3130913 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3130899 /Source="Nicolas_upshifts" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" downshifts complement(3131018) /Source="Nicolas_upshifts" /id="D1672" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="1.28655" /MaxDrop="3.45909" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=264 /isTUend="FALSE" downshifts 3131206 /Source="Nicolas_upshifts" /id="D1673" /incds=0 /nref=258 /ntot=281 /MaxReadThrough="3.6035" /MaxDrop="7.98922" /score="39.7008566" /energy="-19.5" /TU="U2527" /idTUdmin="U2527" /TUdmin="-220" /isTUend="FALSE" CDS complement(3131270..3133243) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8576092, 11406580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acylaminoacyl-peptidase" /protein_id="NP_391103.2" /db_xref="EnsemblGenomes-Gn:BSU32230" /db_xref="EnsemblGenomes-Tr:CAB15213" /db_xref="GOA:P39839" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10463" /db_xref="UniProtKB/Swiss-Prot:P39839" /translation="MKKLITADDITAIVSVTDPQYAPDGTRAAYVKSQVNQEKDSYTS NIWIYETKTGGSVPWTHGEKRSTDPRWSPDGRTLAFISDREGDAAQLYIMSTEGGEAR KLTDIPYGVSKPLWSPDGESILVTVSLGEGESIDDREKTEQDSYEPVEVQGLSYKRDG KGLTRGAYAQLVLVSVKSGEMKELTSHKADHGDPAFSPDGKWLVFSANLTETDDASKP HDVYIMSLESGDLKQVTPHRGSFGSSSFSPDGRYLALLGNEKEYKNATLSKAWLYDIE QGRLTCLTEMLDVHLADALIGDSLIGGAEQRPIWTKDSQGFYVIGTDQGSTGIYYISI EGLVYPIRLEKEYINSFSLSPDEQHFIASVTKPDRPSELYSIPLGQEEKQLTGANDKF VREHTISIPEEIQYATEDGVMVNGWLMRPAQMEGETTYPLILNIHGGPHMMYGHTYFH EFQVLAAKGYAVVYINPRGSHGYGQEFVNAVRGDYGGKDYDDVMQAVDEAIKRDPHID PKRLGVTGGSYGGFMTNWIVGQTNRFKAAVTQRSISNWISFHGVSDIGYFFTDWQLEH DMFEDTEKLWDRSPLKYAANVETPLLILHGERDDRCPIEQAEQLFIALKKMGKETKLV RFPNASHNLSRTGHPRQRIKRLNYISSWFDQHL*" gene complement(3131270..3133243) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" downshifts complement(3131282) /Source="Nicolas_upshifts" /id="D1674" /incds=0 /nref=19 /ntot=114 /MaxReadThrough="1.79797" /MaxDrop="3.85507" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3133258..3133276) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3133281) /Source="Nicolas_upshifts" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" promotor_-35 complement(3133288..3133296) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3133351..3134280) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" /EC_number="2.7.1.39" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine kinase" /protein_id="NP_391104.1" /db_xref="EnsemblGenomes-Gn:BSU32240" /db_xref="EnsemblGenomes-Tr:CAB15214" /db_xref="GOA:P04948" /db_xref="InterPro:IPR000870" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10462" /db_xref="UniProtKB/Swiss-Prot:P04948" /translation="MNEADMLFSVTVPGSTANLGPGFDSVGMALSRYLKLTVFESDKW SFEAETETVAGIPAGTDNLIYQVAKRTADLYGKEMPPVHVKVWSDIPLARGLGSSAAA IVAAIELADELCGLKLSEADKLHLASLEEGHPDNAGASLVGGLVIGLHEDDETQMIRV PNADIDVVVVIPFYEVLTRDARDVLPKEFPYADAVKASAVSNILIAAIMSKDWPLVGK IMKKDMFHQPYRAMLVPELSKVEHVAEMKGAYGTALSGAGPTILVMTEKGKGEELKEQ LALHFPHCEVDALTVPKEGSIIERNPLYQVKSV*" gene complement(3133351..3134280) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" downshifts complement(3133364) /Source="Nicolas_upshifts" /id="D1675" /incds=0 /nref=222 /ntot=261 /MaxReadThrough="2.39521" /MaxDrop="7.03759" /score="15.5945196" /energy="-10.3" /TU="NA" /idTUdmin="U2530" /TUdmin="-14" /isTUend="TRUE" CDS complement(3134277..3135335) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" /EC_number="4.2.3.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 3139660, 8768250" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 3139660, 8768250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine synthase" /protein_id="NP_391105.1" /db_xref="EnsemblGenomes-Gn:BSU32250" /db_xref="EnsemblGenomes-Tr:CAB15215" /db_xref="GOA:P04990" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR004450" /db_xref="InterPro:IPR026260" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10461" /db_xref="UniProtKB/Swiss-Prot:P04990" /translation="MWKGLIHQYKEFLPVTDQTPALTLHEGNTPLIHLPKLSEQLGIE LHVKTEGVNPTGSFKDRGMVMAVAKAKEEGNDTIMCASTGNTSAAAAAYAARANMKCI VIIPNGKIAFGKLAQAVMYGAEIIAIDGNFDDALKIVRSICEKSPIALVNSVNPYRIE GQKTAAFEVCEQLGEAPDVLAIPVGNAGNITAYWKGFKEYHEKNGTGLPKMRGFEAEG AAAIVRNEVIENPETIATAIRIGNPASWDKAVKAAEESNGKIDEVTDDEILHAYQLIA RVEGVFAEPGSCASIAGVLKQVKSGEIPKGSKVVAVLTGNGLKDPNTAVDISEIKPVT LPTDEDSILEYVKGAARV*" gene complement(3134277..3135335) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" CDS complement(3135335..3136636) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" /EC_number="1.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3139660, 27299409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3139660, 27299409; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine dehydrogenase" /protein_id="NP_391106.1" /db_xref="EnsemblGenomes-Gn:BSU32260" /db_xref="EnsemblGenomes-Tr:CAB15216" /db_xref="GOA:P19582" /db_xref="InterPro:IPR001342" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005106" /db_xref="InterPro:IPR016204" /db_xref="InterPro:IPR019811" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10460" /db_xref="UniProtKB/Swiss-Prot:P19582" /translation="MKAIRVGLLGLGTVGSGVVKIIQDHQDKLMHQVGCPVTIKKVLV KDLEKKREVDLPKEVLTTEVYDVIDDPDVDVVIEVIGGVEQTKQYLVDALRSKKHVVT ANKDLMAVYGSELLAEAKENGCDIYFEASVAGGIPILRTLEEGLSSDRITKMMGIVNG TTNFILTKMIKEKSPYEEVLKEAQDLGFAEADPTSDVEGLDAARKMAILARLGFSMNV DLEDVKVKGISQITDEDISFSKRLGYTMKLIGIAQRDGSKIEVSVQPTLLPDHHPLSA VHNEFNAVYVYGEAVGETMFYGPGAGSMPTATSVVSDLVAVMKNMRLGVTGNSFVGPQ YEKNMKSPSDIYAQQFLRIHVKDEVGSFSKITSVFSERGVSFEKILQLPIKGHDELAE IVIVTHHTSEADFSDILQNLNDLEVVQEVKSTYRVEGNGWS*" gene complement(3135335..3136636) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" promotor_-35 3136521..3136530 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3136545..3136564 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3136552 /Source="Nicolas_upshifts" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(3136637..3136718) /Source="Nicolas_S_feature" /locus_tag="new_3316130_3316211_c" /HighExp="T3.0H, T2.30H, T3.30H, S2, C90, T4.0H, BMM, SMM, MG 120, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1245" promotor_-10 complement(3136703..3136722) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3136718) /Source="Nicolas_upshifts" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" S_feature complement(3136720..3136836) /Source="Nicolas_S_feature" /locus_tag="new_3316213_3316329_c" /HighExp="S5, S3, S4, S7, S6, S8, BT, B36, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1246" promotor_-35 complement(3136737..3136744) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3136837..3137856) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" /function="16.3: Control" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15231775, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat-associated protein" /protein_id="NP_391107.1" /db_xref="EnsemblGenomes-Gn:BSU32270" /db_xref="EnsemblGenomes-Tr:CAB15217" /db_xref="GOA:O32123" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014254" /db_xref="SubtiList:BG14044" /db_xref="UniProtKB/Swiss-Prot:O32123" /translation="MVKGTIKEKYGIHIRQLSMYQHTYQCFQTPNSYFLIVPVSQFSE TELAELYYMSQYLQEQSDPYVSVFIFTKEGELTFEHEGKTYALLKAAPPYSNRAFSIG AELAEFHRKGRGYPYEVKAAGRIGQWKDLWGKRIDQLEAFWQRKVQTPPHEPFDKKMI ESFPYYLGLSENAIQYLVDTELDDKPQAADSGTICHQRMERHTWSPESLIRIPADWVF DHASRDLAEYMRHTFLHHRQDFNQQGFLFLQEYEQVTPLSSFSKRLLYSRLLFPLHYF EIVESYYMSSESEKHYFEEQLDFILNDCGRYEQFLNTAQEFMNMRAQKLFVPRVSWLG KGSSR*" gene complement(3136837..3137856) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" promotor_-35 3137664..3137669 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3137685..3137703 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3137689 /Source="Nicolas_upshifts" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3137879..3137897) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3137886) /Source="Nicolas_upshifts" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" promotor_-35 3137895..3137900 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3137913..3137918) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3137916..3137980 /Source="Nicolas_S_feature" /locus_tag="new_3317409_3317473" /HighExp="S4, S5, S3, S6, S7, B36, S8, LoTm, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1247" promotor_-10 3137916..3137934 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3137916 /Source="Nicolas_upshifts" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" promotor_-35 3137953..3137962 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3137975..3137994 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3137982 /Source="Nicolas_upshifts" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" CDS 3138009..3138509 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_391108.1" /db_xref="EnsemblGenomes-Gn:BSU32280" /db_xref="EnsemblGenomes-Tr:CAB15218" /db_xref="GOA:O32124" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="SubtiList:BG14043" /db_xref="UniProtKB/Swiss-Prot:O32124" /translation="MSENEQFSQMEAKARARMKERGVEVSDIAELVFFLQKKYHPDLT IDECTLNVNRVLAKREVQNAILTGIELDVLAEQKKLSEPLQTMLEIDESLYGVDEVLA FSIVNIYGSIGFTNYGYIDKEKPGILKRLNDKSTGECHTFLDDIVGAISAAASSRLAH RARHTE*" gene 3138009..3138509 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" CDS complement(3138536..3139306) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" /EC_number="3.1.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15664928, 16766528, 27907199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15664928, 16766528, 27907199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5' nucleotidase, promiscuous" /protein_id="NP_391109.1" /db_xref="EnsemblGenomes-Gn:BSU32290" /db_xref="EnsemblGenomes-Tr:CAB15219" /db_xref="GOA:O32125" /db_xref="InterPro:IPR006354" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3PDW" /db_xref="SubtiList:BG14042" /db_xref="UniProtKB/Swiss-Prot:O32125" /translation="MKTYKGYLIDLDGTMYNGTEKIEEACEFVRTLKDRGVPYLFVTN NSSRTPKQVADKLVSFDIPATEEQVFTTSMATAQHIAQQKKDASVYVIGEEGIRQAIE ENGLTFGGENADFVVVGIDRSITYEKFAVGCLAIRNGARFISTNGDIAIPTERGLLPG NGSLTSVLTVSTGVQPVFIGKPESIIMEQAMRVLGTDVSETLMVGDNYATDIMAGINA GMDTLLVHTGVTKREHMTDDMEKPTHAIDSLTEWIPYI*" gene complement(3138536..3139306) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" downshifts complement(3138564) /Source="Nicolas_upshifts" /id="D1676" /incds=0 /nref=137 /ntot=243 /MaxReadThrough="2.15034" /MaxDrop="4.82801" /score="8.09889752" /energy="-15.6" /TU="NA" /idTUdmin="U2535" /TUdmin=0 /isTUend="TRUE" CDS complement(3139335..3139769) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391110.1" /db_xref="EnsemblGenomes-Gn:BSU32300" /db_xref="EnsemblGenomes-Tr:CAB15220" /db_xref="InterPro:IPR008201" /db_xref="PDB:1YLM" /db_xref="SubtiList:BG14041" /db_xref="UniProtKB/Swiss-Prot:O32126" /translation="MYFVDRSKIEKTLGFFEHQLALFDSQTDWQSEIGELALQRIGHL LIECILDTGNDMIDGFIMRDPGSYDDIMDILVDEKVVTEKEGDELKKLIAYRKTLVQQ YLLADSGELYRLIKAHQTALQDFPKRIRSYLETELGPVSAFK*" gene complement(3139335..3139769) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" CDS complement(3139793..3140068) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12770717, 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391111.2" /db_xref="EnsemblGenomes-Gn:BSU32310" /db_xref="EnsemblGenomes-Tr:CAB15221" /db_xref="InterPro:IPR009370" /db_xref="PDB:2KL5" /db_xref="SubtiList:BG14040" /db_xref="UniProtKB/Swiss-Prot:O32127" /translation="MILIQNAEFELVHNFKDGFNEEAFKARYSDILNKYDYIVGDWGY GQLRLKGFFDDQNQKATFETKISTLDEYIYEYCNFGCAYFVLKRIRK*" gene complement(3139793..3140068) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" promotor_-10 complement(3140088..3140107) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3140113) /Source="Nicolas_upshifts" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" S_feature complement(3140115..3140807) /Source="Nicolas_S_feature" /locus_tag="new_3319608_3320300_c" /HighExp="G135, G150, G180, H2O2, LBGtran, LBGexp, Paraq, dia15, C90, HiOs" /AntisenseName="yutC" /AntisenseCor="-0.57886192731570996" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1248" promotor_-35 complement(3140121..3140128) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3140131..3140137 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3140152..3140163 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3140160 /Source="Nicolas_upshifts" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" CDS 3140183..3140815 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative sporulation-related lipoprotein" /protein_id="NP_391112.1" /db_xref="EnsemblGenomes-Gn:BSU32320" /db_xref="EnsemblGenomes-Tr:CAB15222" /db_xref="GOA:O32128" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG14039" /db_xref="UniProtKB/Swiss-Prot:O32128" /translation="MKRTAVSLCLLTGLLSGCGGAGLDNAQNVRNQTQNQTKPIHVSD RNEAFNRHNENEQFGYVRYQKEQFDGEQQKTPVMNREETAHMISSLTVQLPHIQDAAT LVTDREALVVYKTDSKNRELTADQVKKTAASVIPRYYHVYISDNPNHMQSVENYSNLG SGSRDIREIMSGTIQEMKTSPQGSPVSENENANGETRQDMKIDRNDKNAR*" gene 3140183..3140815 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" downshifts 3140776 /Source="Nicolas_upshifts" /id="D1677" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="1.84979" /MaxDrop="3.55825" /score="-2.38634221" /energy="-9.6" /TU="NA" /idTUdmin="U2536" /TUdmin=0 /isTUend="TRUE" CDS complement(3140831..3141727) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" /EC_number="2.8.1.8" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15362861, 16835858, 19028902, 19820084, 25341020; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoyl synthase (lipoic acid synthetase)" /protein_id="NP_391113.2" /db_xref="EnsemblGenomes-Gn:BSU32330" /db_xref="EnsemblGenomes-Tr:CAB15223" /db_xref="GOA:O32129" /db_xref="InterPro:IPR003698" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031691" /db_xref="SubtiList:BG14038" /db_xref="UniProtKB/Swiss-Prot:O32129" /translation="MAKKDEHLRKPEWLKIKLNTNENYTGLKKLMRENNLHTVCEEAK CPNIHECWAVRRTATFMILGSVCTRACRFCAVKTGLPTELDLQEPERVADSVALMNLK HAVITAVARDDQKDGGAGIFAETVRAIRRKSPFTTIEVLPSDMGGNYDNLKTLMDTRP DILNHNIETVRRLTPRVRARATYDRSLEFLRRAKEMQPDIPTKSSIMIGLGETKEEII EVMDDLLANNVDIMAIGQYLQPTKKHLKVQKYYHPDEFAELKEIAMQKGFSHCEAGPL VRSSYHADEQVNEASKKRQAQA*" gene complement(3140831..3141727) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" downshifts complement(3140852) /Source="Nicolas_upshifts" /id="D1678" /incds=0 /nref=186 /ntot=261 /MaxReadThrough="3.83236" /MaxDrop="5.33309" /score="14.803008" /energy="-9.6" /TU="U2537" /idTUdmin="U2537" /TUdmin="-726" /isTUend="FALSE" S_feature complement(3141728..3141862) /Source="Nicolas_S_feature" /locus_tag="new_3321221_3321355_c" /HighExp="HiOs, LBGtran, dia15, dia5, C90, Diami, dia0, LBGexp, Heat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1249" promotor_-10 complement(3141849..3141868) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-10" upshifts complement(3141862) /Source="Nicolas_upshifts" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" promotor_-35 complement(3141884..3141888) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-35" promotor_-35 3141902..3141908 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3141922..3141933 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3141934 /Source="Nicolas_upshifts" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" CDS 3141962..3142942 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" /EC_number="3.4.-.-" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12813075; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific L-Ala-D-Glu endopeptidase" /protein_id="NP_391114.2" /db_xref="EnsemblGenomes-Gn:BSU32340" /db_xref="EnsemblGenomes-Tr:CAB15224" /db_xref="GOA:O32130" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG13975" /db_xref="UniProtKB/Swiss-Prot:O32130" /translation="MKVLLSALLLLLFAFEPSASGKKLSDPVLSKRMELYHKIEAVTQ IPWYALAAVDQYEENVRSNRKDLPEKAGIISIYIPDDIWSGPENPNPKDDAPLSIKVF DGIGMDGDGDGKAEVSNDEDILYTFSQYLLSYGTDEDNIRIGLWNYYRRDQTVGIISE FMKLFKAYGHIDLGEHAFPLPIRTDYSYRSTWGDARGFGGRRIHEGTDIFAHYGLPVK STCYGVVEMKGWNRFGGWRIGIRDINNTYHYFAHLNGFAKGIKTGQIVEPGQVIGSVG SSGYGPPGTAGKFPPHLHYGMYKDNGRTEWSFDPYPHLRAWERYEYQKKK*" gene 3141962..3142942 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" upshifts complement(3142040) /Source="Nicolas_upshifts" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3142054..3142073) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3142090..3142093) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3142934 /Source="Nicolas_upshifts" /id="D1679" /incds=0 /nref=35 /ntot=74 /MaxReadThrough="0.613989999999999" /MaxDrop="8.59238" /score="-3.31011906" /energy="-20" /TU="NA" /idTUdmin="U2538" /TUdmin=2 /isTUend="TRUE" CDS complement(3142970..3143734) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12662922, 23388828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 23388828; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein required for membrane fission during spore formation" /protein_id="NP_391115.1" /db_xref="EnsemblGenomes-Gn:BSU32350" /db_xref="EnsemblGenomes-Tr:CAB15225" /db_xref="GOA:O32131" /db_xref="InterPro:IPR014197" /db_xref="SubtiList:BG13976" /db_xref="UniProtKB/Swiss-Prot:O32131" /translation="MPRYRGPFRKRGPLPFRYVMLLSVVFFILSTTVSLWMINGSIKP VLMDIGEMETKRIATEVIQDSIEDYMSDSENMKDMFQMNSDENGNLTTIDFNTQVVNS VKTKVTKQLQAHLKEMETHTGHSGASENIMINIPLGQVTGNSLLGNLGPKIPVRFNLI GDAFTDVKTKIKPYGINNALIDISIFVEIKVKVIIPFASKTAVVTNNVPVSIKAVQGE VPQFYNGSGGSGVTPSVQLPSSKENGADSKKEKSSK*" gene complement(3142970..3143734) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" downshifts complement(3142986) /Source="Nicolas_upshifts" /id="D1680" /incds=0 /nref=74 /ntot=226 /MaxReadThrough="3.15258" /MaxDrop="6.53891" /score="23.5286262" /energy="-12.4" /TU="NA" /idTUdmin="U2540" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3143748..3143766) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3143756) /Source="Nicolas_upshifts" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" promotor_-35 complement(3143782..3143787) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3143807..3144112) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391116.1" /db_xref="EnsemblGenomes-Gn:BSU32360" /db_xref="EnsemblGenomes-Tr:CAB15226" /db_xref="InterPro:IPR014931" /db_xref="InterPro:IPR036493" /db_xref="SubtiList:BG13977" /db_xref="UniProtKB/Swiss-Prot:O32132" /translation="MVNLTPIMIEGQPFTAVTVKLPKTNFMAVANDHGYIMCGALDVA LLNEKLKERGIVAGRAVGVRTIDQLLDAPLESVTYAAEDLGIKVGMSGREALLKMMK* " gene complement(3143807..3144112) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" downshifts complement(3143815) /Source="Nicolas_upshifts" /id="D1681" /incds=0 /nref=3 /ntot=128 /MaxReadThrough="5.18714" /MaxDrop="3.9347" /score="-2.65376612" /energy="-18.9" /TU="U2541,U2543,U2544" /idTUdmin="U2540" /TUdmin="-829" /isTUend="FALSE" promotor_-10 complement(3144126..3144145) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3144149) /Source="Nicolas_upshifts" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" promotor_-35 complement(3144159..3144167) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3144177..3145565) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nuclease/nucleotidase/phosphoesterase" /protein_id="NP_391117.1" /db_xref="EnsemblGenomes-Gn:BSU32370" /db_xref="EnsemblGenomes-Tr:CAB15227" /db_xref="GOA:O32133" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR011240" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG13978" /db_xref="UniProtKB/Swiss-Prot:O32133" /translation="MKEKLRLYHTNDLHSHFENWPKIVDYIEQKRKEHQSDGEETLVF DIGDHLDRFQFVTEATFGKANVDLLNRLHIDGAAIGNNEGITLPHEELAALYDHAEFP VIVSNLFDKNGNRPSWAVPYHIKSLKNGMSIAFLGVTVPYYPVYDKLGWTVTDALESI KETILEVKGQADIIVLLSHLGILDDQAVAEAVPEIDVILESHTHHLLEDGQVVNGVLL ASAEKYGHYVGCVEITVDSVQRSINSKTASVQNMAEWTGESAETKAFLNEKEREAEEK LSDAVAELAQDAEVKWFEESELPLLLAYALKEWCETDISMVNSGVILGPLKAGPVTKL DLHRICPHPINPVAVRLTGEELKETIVHAASEQMEQLRIKGLGFRGEVMGKMVYAGVE VETKRLDDGITHVTRITLNGEDIEKHKQYSVAVLDMFTLGKLFPLIRDAAEKEYFMPE FLRDLLAWKLAQ*" gene complement(3144177..3145565) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" CDS complement(3145585..3146406) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391118.1" /db_xref="EnsemblGenomes-Gn:BSU32380" /db_xref="EnsemblGenomes-Tr:CAB15228" /db_xref="GOA:O32134" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13979" /db_xref="UniProtKB/Swiss-Prot:O32134" /translation="MSFVILVVLGLIAGTVGSLIGLGGGIVIVPSLMFLSTVTQLFQD VTPQVAIGTSLLVIIFTGLSSTLAYIKYKTVDYKSGLIFFIGSGPGSMIGAYVSKLFN SNSFSVWFGIFMILISLSLMLKAKARPINKAHKGIIRTFQDDAGEPYTYSYQASVGIA IAFVVGFLGGLFGIGGGSLMVPAMMLLFLFPPKVAVATSMFIIFLSSMTGSVSHMISG HVNWLYALALVPGAWFGGKLGAAINRKMQTKTIVMIMRIVLILIGCQLIYEGIFS*" gene complement(3145585..3146406) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" CDS complement(3146424..3147272) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391119.2" /db_xref="EnsemblGenomes-Gn:BSU32390" /db_xref="EnsemblGenomes-Tr:CAB15229" /db_xref="InterPro:IPR002763" /db_xref="InterPro:IPR036520" /db_xref="SubtiList:BG13980" /db_xref="UniProtKB/Swiss-Prot:O32135" /translation="MIYIGLTGWGDHDSIYPPKTASQKKLQAYSSHFPIVELDASFYA IQPARNNEKWVKETPETFQFIVKAYQGMTGHQRGEIPFDSKEEMFDAFKVSLTPYLHS NKLAMVLFQFPPWFDCKKENVAYLRWCKHQMGDIPCALEFRNRSWFSPPFYEQTLSFM KAEGWIHSVCDEPQIGEGSVPTVLRATDENKTLVRFHGRNKQGWMKPDGGKNWREVRY LYRYNQQELEDWKKHLNELQQQCKDVFVLFNNNSGGDAADNGKQMLELLDIEYSGLAP RQLDLF*" gene complement(3146424..3147272) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" promotor_-35 3146791..3146796 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3146812..3146830 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3146826 /Source="Nicolas_upshifts" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(3147283..3147302) /Source="Nicolas_upshift_promotors" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3147298) /Source="Nicolas_upshifts" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" CDS complement(3147310..3147657) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391120.1" /db_xref="EnsemblGenomes-Gn:BSU32400" /db_xref="EnsemblGenomes-Tr:CAB15230" /db_xref="SubtiList:BG13981" /db_xref="UniProtKB/Swiss-Prot:O32136" /translation="MEHVKYILKQSWSRHSSSKWTEECPSCGQCGVTALVIQDHFGGT IFKTRVDESWHFYNSINGVVYDFTSEQFQAPIEYQHIPSSREEAFLDTNEEQYQHLRE AFSRHMNSISEET*" gene complement(3147310..3147657) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" promotor_-10 complement(3147670..3147689) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3147689) /Source="Nicolas_upshifts" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" promotor_-35 complement(3147703..3147709) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3147754..3149094) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" /EC_number="3.5.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoinase" /protein_id="NP_391121.1" /db_xref="EnsemblGenomes-Gn:BSU32410" /db_xref="EnsemblGenomes-Tr:CAB15231" /db_xref="GOA:O32137" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR017593" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13982" /db_xref="UniProtKB/Swiss-Prot:O32137" /translation="MAYDMVIKGAKAVTPDGVIEADIVVQNGVIAEIGSDIEASGTEI IQADGKYVFPGVIDCHVHFNEPGREDWEGFETGSQMMAAGGCTTYFDMPLNCIPSTVT AEHLLAKAELGRQKSAVDFALWGGLVPGHIEDIRPMAEAGAIGFKAFLSKSGTDEFRS VDERTLLKGMAEIAAAGKILALHAESDAITSYLQMVLANKGKVDADAYAASRPEEAEV EAVYRTIQYAKVTGCPVHFVHISTAKAVRLIREAKQEGLDVSVETCPHYVLFSHDDLR QRGSVAKCAPPLRSRQSKETLIETLIAGDIDMVSSDHSPCRPSLKREDNMFLSWGGIS GGQFTLLGMLELALEHQIPFETIAEWTAAAPAKRFGLQKKGRLEAGCDADFVLVSMEP YTVTRESMFAKHKKSIYEGHTFPCSISATYSKGRCVYNDGEKVTEIDGALVVPS*" gene complement(3147754..3149094) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" downshifts complement(3147782) /Source="Nicolas_upshifts" /id="D1682" /incds=0 /nref=5 /ntot=28 /MaxReadThrough="0.88847" /MaxDrop="3.89144" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-4796" /isTUend="FALSE" downshifts complement(3148838) /Source="Nicolas_upshifts" /id="D1683" /incds=1 /nref=1 /ntot=7 /MaxReadThrough="3.38784" /MaxDrop="3.36547" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-5852" /isTUend="FALSE" promotor_-35 3149151..3149157 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3149171..3149190 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3149173..3149191) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3149179 /Source="Nicolas_upshifts" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" S_feature 3149180..3149268 /Source="Nicolas_S_feature" /locus_tag="new_3328673_3328761" /HighExp="BT, Cold, S0, LBGexp, S1, Lbtran, G150, T-1.40H, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S1250" upshifts complement(3149190) /Source="Nicolas_upshifts" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3149207..3149212) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3149269..3150864 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 12374841" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 12374841; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine degradation operon" /protein_id="NP_391122.1" /db_xref="EnsemblGenomes-Gn:BSU32420" /db_xref="EnsemblGenomes-Tr:CAB15232" /db_xref="GOA:O32138" /db_xref="InterPro:IPR012914" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG13983" /db_xref="UniProtKB/Swiss-Prot:O32138" /translation="MNILDVMKIPAFENANLIAGKAGGEREVQHVNMMDAPDIVDFLH KNELLVTTAYHLKDHPHQLSELIRQMAKRGCAGLGIKTKRYLEDIPKEIIELADSYAF PIIELPEHIRLGDIVNATLSHILDMRSNELQQAIYAHKKFTNHIMSGKGLQSLLKKVS DILQLPVLLLDQHAKMLSASHQISVETEKLKGTLNTVSGPFFTCFSTISDQKTYSVLP IYNHEKNCGYLLIPDMVQAGDKGLILTIEQAANVISFELLKENALKQFSRRARNEFFN NFIERTFSSDDEIKNRAKEFKLRWDQKYMCIAGKLDRNDESISFTENQLASDSVFEFL EGELSAFPFPPHFFMKGNVGIILIEATDSWSEMHASVISFLEQFQTQVSAQFKRTVSF GISNICQKLIDVPDAFTEASDALQSGHLSRSTAFIQVYHAKDVPELLRLLPVEDLKKF YNSTLQSLAEKQQEDQSLLHTLSVYLETHCQISETAKRLYVHRNTVIYRLEKCEELLG KSLKDPETTMRLRLALRMQRLIS*" gene 3149269..3150864 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" CDS 3151009..3152358 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease" /protein_id="NP_391123.1" /db_xref="EnsemblGenomes-Gn:BSU32430" /db_xref="EnsemblGenomes-Tr:CAB15233" /db_xref="GOA:O32139" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13984" /db_xref="UniProtKB/Swiss-Prot:O32139" /translation="MKKRSFKVFTLSLQHVLAMYAGAILVPLLVGRALNVTTEQLSYL LAIDLLTCGVATLLQTLRGTYIGIGLPVMLGSSFVAVTPMIAIGSNYGIHAIYGSIIA AGVFIFLFARFFGKLTVLFPPVVTGTVVTLIGLSLVPTGVKNMAGGEKINGSANPEYG SLENLLLSVGVLVLILVLNRFLKGFARTLSVLIGIAAGTAAAAIMGKVSFSSVTEAPF FQIPKPFYFGAPAFEIGPILTMLIVGIVIIVESTGVFYAIGKICGRPLTDKDLVKGYR AEGIAILIGGLFNAFPYNTFAQNAGLLQLTKVKTRNIVVTAGCILVCLGLIPKIAALA SAVPAAVLGGATVVMFGMVIASGVKMLSTADLKNQYHLLTIACSIALGIGASTAPGIF AEFPAPIRILVSDGTITGSLTAIFLNLFFSLRDKKELTAQQTELPVLEHTLALEKEV* " gene 3151009..3152358 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" CDS 3152364..3153656 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease subunit" /protein_id="NP_391124.1" /db_xref="EnsemblGenomes-Gn:BSU32440" /db_xref="EnsemblGenomes-Tr:CAB15234" /db_xref="GOA:O32140" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13985" /db_xref="UniProtKB/Swiss-Prot:O32140" /translation="MKEQHNALQLMMLGLQHMLAMYAGAILVPLIVGAAIGLNAGQLT YLIAIDLFMCGAATLLQLWRNRYFGIGLPVVLGCTFTAVGPMISIGSTYGVPAIYGAI IAAGLIVVLAAGFFGKLVRFFPPVVTGSVVMIIGISLIPTAMNNLAGGEGSKEFGSLD NVLLGFGVTAFILLLFYFFKGFIRSIAILLGLIAGTAAAYFMGKVDFSEVLEASWLHV PSLFYFGPPTFELPAVVTMLLVAIVSLVESTGVYFALADITNRRLSEKDLEKGYRAEG LAILLGGLFNAFPYTAFSQNVGIVQLSKMKSVNVIAITGIILVAIGLVPKAAALTTVI PTPVLGGAMIVMFGMVISYGIKMLSSVDLDSQGNLLIIASSVSLGLGATTVPALFSSL SGAASVLAGSGIVIGSLTAIALHAFFQTKQPNSADIKT*" gene 3152364..3153656 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" CDS 3153669..3155153 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" /EC_number="1.7.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12823818, 17567580, 20168977, 23760935, 28531234" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12823818, 17567580, 20168977, 23760935, 28531234; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="urate oxidase with peroxide reductase N-terminaldomain" /protein_id="NP_391125.1" /db_xref="EnsemblGenomes-Gn:BSU32450" /db_xref="EnsemblGenomes-Tr:CAB15235" /db_xref="GOA:O32141" /db_xref="InterPro:IPR002042" /db_xref="InterPro:IPR017580" /db_xref="InterPro:IPR018020" /db_xref="InterPro:IPR019842" /db_xref="InterPro:IPR036778" /db_xref="SubtiList:BG13986" /db_xref="UniProtKB/Swiss-Prot:O32141" /translation="MFTMDDLNQMDTQTLTDTLGSIFEHSSWIAERSAALRPFSSLSD LHRKMTGIVKAADRETQLDLIKKHPRLGTKKTMSDDSVREQQNAGLGKLEQQEYEEFL MLNEHYYDRFGFPFILAVKGKTKQDIHQALLARLESERETEFQQALIEIYRIARFRLA DIITEKGETQMKRTMSYGKGNVFAYRTYLKPLTGVKQIPESSFAGRDNTVVGVDVTCE IGGEAFLPSFTDGDNTLVVATDSMKNFIQRHLASYEGTTTEGFLHYVAHRFLDTYSHM DTITLTGEDIPFEAMPAYEEKELSTSRLVFRRSRNERSRSVLKAERSGNTITITEQYS EIMDLQLVKVSGNSFVGFIRDEYTTLPEDGNRPLFVYLNISWQYENTNDSYASDPARY VAAEQVRDLASTVFHELETPSIQNLIYHIGCRILARFPQLTDVSFQSQNHTWDTVVEE IPGSKGKVYTEPRPPYGFQHFTVTREDAEKEKQKAAEKCRSLKA*" gene 3153669..3155153 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" CDS 3155153..3155497 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" /EC_number="3.5.2.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 16098976, 16782815, 21795808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 16098976, 16782815, 21795808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-hydroxyisourate hydrolase; also uricase subunit" /protein_id="NP_391126.2" /db_xref="EnsemblGenomes-Gn:BSU32460" /db_xref="EnsemblGenomes-Tr:CAB15236" /db_xref="GOA:O32142" /db_xref="InterPro:IPR000895" /db_xref="InterPro:IPR014306" /db_xref="InterPro:IPR023416" /db_xref="InterPro:IPR023418" /db_xref="InterPro:IPR023419" /db_xref="InterPro:IPR036817" /db_xref="PDB:2H0E" /db_xref="PDB:2H0F" /db_xref="PDB:2H0J" /db_xref="SubtiList:BG13987" /db_xref="UniProtKB/Swiss-Prot:O32142" /translation="MGKLTTHILDLTCGKPAANVKIGLKRLGESIMKEVYTNNDGRVD VPLLAGEELMSGEYVMEFHAGDYFASKNMNAADQPFLTIVTVRFQLADPDAHYHIPLL LSPFGYQVYRGS*" gene 3155153..3155497 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" promotor_-35 3155219..3155222 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3155240..3155259 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3155252 /Source="Nicolas_upshifts" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 3155472 /Source="Nicolas_upshifts" /id="D1684" /incds=0 /nref=3 /ntot=90 /MaxReadThrough="1.80149" /MaxDrop="3.57243" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2547" /TUdmin=0 /isTUend="TRUE" S_feature complement(3155513..3155900) /Source="Nicolas_S_feature" /locus_tag="new_3335006_3335393_c" /HighExp="BT, S8, T2.0H, LBGstat, Cold, Etha, Sw, T1.0H, T1.30H, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1251" promotor_-35 3155860..3155869 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3155882..3155901 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3155885 /Source="Nicolas_upshifts" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" ncRNA complement(3155921..3156052) /ncRNA_class="antisense_RNA" /gene="auzJ" /locus_tag="BSU_ncRNA_2" /product="putative antisense RNA for type I YuzJ toxin" /note="Evidence 3: Putative function from multiple computational evidences" CDS 3155921..3156052 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 20525796, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097780.1" /db_xref="EnsemblGenomes-Gn:BSU32469" /db_xref="EnsemblGenomes-Tr:CAX52686" /db_xref="GOA:C0H3Q7" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Q7" /translation="MGFYNSGGYSGNSGYSNGFGSSFALIVVLFILLIIVGAAIFNY* " gene 3155921..3156052 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" gene complement(3155921..3156052) /gene="auzJ" /locus_tag="BSU_ncRNA_2" S_feature 3156053..3156121 /Source="Nicolas_S_feature" /locus_tag="new_3335546_3335614" /HighExp="BT, B36, S8, G/S, B60, Pyr, Glucon, C30, S7, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1252" downshifts 3156088 /Source="Nicolas_upshifts" /id="D1685" /incds=0 /nref=10 /ntot=25 /MaxReadThrough="0.61379" /MaxDrop="6.43101" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2548" /TUdmin=0 /isTUend="TRUE" CDS complement(3156258..3156779) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, iron-sulfur subunit" /protein_id="NP_391127.1" /db_xref="EnsemblGenomes-Gn:BSU32470" /db_xref="EnsemblGenomes-Tr:CAB15237" /db_xref="GOA:O32143" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR002888" /db_xref="InterPro:IPR006058" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017611" /db_xref="InterPro:IPR036010" /db_xref="InterPro:IPR036884" /db_xref="SubtiList:BG13988" /db_xref="UniProtKB/Swiss-Prot:O32143" /translation="MDIKEAGPFPVKKEQFRMTVNGQAWEVAAVPTTHLSDLLRKEFQ LTGTKVSCGIGRCGACSILIDGKLANACMTMAYQADGHSITTIEGLQKEELDMCQTAF LEEGGFQCGYCTPGMIIALKALFRETPQPSDKDIEEGLAGNLCRCTGYGGIMRSACRI RRELNGGRRESGF*" gene complement(3156258..3156779) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" CDS complement(3156770..3159007) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, substrate and molybdenumcofactor subunit" /protein_id="NP_391128.1" /db_xref="EnsemblGenomes-Gn:BSU32480" /db_xref="EnsemblGenomes-Tr:CAB15238" /db_xref="GOA:O32144" /db_xref="InterPro:IPR000674" /db_xref="InterPro:IPR008274" /db_xref="InterPro:IPR017609" /db_xref="InterPro:IPR036856" /db_xref="InterPro:IPR037165" /db_xref="SubtiList:BG13989" /db_xref="UniProtKB/Swiss-Prot:O32144" /translation="MIINKPSRVRPDGRGKVTGELKYMTDLSFPGMLYGKVLRSAYPH AEIVSVCTIKAEKMEGVQAVVTHKDVPGLNRFGIVIPDQPVLCEDRVRYVGDAIAAVA AETEEIAEAALELIQVEYKELEVMDSPEKALRPNAQRLHEDGNILHRAFFSNGDVEEG FQASDTVFEETYELPRQMHTYMETEGGVAVPEDDGGFTMYAGTQHGYKDRFQLARIFD IPEEKIRIVSSPMGGSFGGKDELNIQPYAALLALKSGRPVKIHQTRKESVRSGIKRHP MKITIKTGADHSGNLLAHDVKIVADTGAYATLGPAVLDFSVEHAAGPYRIPNIRTEGI SVFTNNGVAGEFRGFGGNQITFALETHLDRLSGMLGIDPLELRRKNIRKPHDLGPLEH RIAPTDGAAQVLNAISKSPILKKTSRNCGYLQRGTGAAITMHGGGLGFGRMDAAGGRL SLSSEGKITASFGFEECGQGILAAIEQIVMEELGCAAEDISIVIGDTAKVPKSGSSTA SRGTSMVWHAIQRLKKPFLAQLKKRAAEWSGCSAENLIPGAAGLRDKNTKALVVTYKE LAEKGPLAEETAFDFPTTPDPVVGGHFLYSFGAAAVEVEVDLLTGDVKLIDCEHAIAA GPVVSPQGYRGQIEGGAAMALGYTLMEEAKMTDGRYAAENLDHYLIPGIKDVPDMKLI AIEDLMKGDVYGPRGVGEIGTIAITPAIVKAVHDAVGCWINKLPISREELLEAIDRKG LKQWT*" gene complement(3156770..3159007) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" CDS complement(3159008..3159841) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, FAD-binding subunit" /protein_id="NP_391129.1" /db_xref="EnsemblGenomes-Gn:BSU32490" /db_xref="EnsemblGenomes-Tr:CAB15239" /db_xref="GOA:O32145" /db_xref="InterPro:IPR002346" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR017612" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036683" /db_xref="SubtiList:BG13990" /db_xref="UniProtKB/Swiss-Prot:O32145" /translation="MNGQVTKARMNIQLWRPAALDEAYSLLEKLAPDVCAASGSTLLQ LQWDKGTLPKQHLVSLEGIDEMRGISTSDTHVSIGGLTSLNECRKNPLIKRALSCFSD AASAVAAPGIRSRATIGGNIASKIGDFIPLLLVLGAELIVYQKELIRLPLGAWLSEED FRTAIVTRVIIPRAEGERVFYHKLGRRQAFTGAAAVAAGRFLKDGSIRLAAGHADITP RRLLDSEAKWMAPGWDPHELYKTLIHELPFSSDVFMSAAYRKKAAANVIMAELMAEGG E*" gene complement(3159008..3159841) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" CDS complement(3159838..3160455) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" /EC_number="2.7.7.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11344136, 21528011; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin cofactor synthesis cytidylyl transferase" /protein_id="NP_391130.2" /db_xref="EnsemblGenomes-Gn:BSU32500" /db_xref="EnsemblGenomes-Tr:CAB15240" /db_xref="GOA:O32146" /db_xref="InterPro:IPR017615" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13991" /db_xref="UniProtKB/Swiss-Prot:O32146" /translation="MRSPYLIGVFLAAGKSRRMGQNKLALPLKGENIGSLSLKTALSS RLDHVLVVERTEHASLEWIGAPYHAPPFQKRWSLHVCQDAEKGQGHSVSSGVRKAESM GADGIVILLADQPQLSVDHLNALVALAPESFAVSSFLGAFTPPIYFSSTCFPYVKGLK GDEGARRLLKSGQLGAGAVLEAKDSGELDDIDTPEEYDMVRRAMS*" gene complement(3159838..3160455) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" downshifts complement(3159947) /Source="Nicolas_upshifts" /id="D1686" /incds=1 /nref=3 /ntot=13 /MaxReadThrough="5.34639" /MaxDrop="3.22355" /score="-4.87239629" /energy="-9.9" /TU="U2549" /idTUdmin="U2549" /TUdmin="-3827" /isTUend="FALSE" CDS complement(3160452..3161444) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10217763, 11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217763, 11344136, 12029039; Product type f: factor" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase molybdopterin recruitmentfactor" /protein_id="NP_391131.1" /db_xref="EnsemblGenomes-Gn:BSU32510" /db_xref="EnsemblGenomes-Tr:CAB15241" /db_xref="GOA:O32147" /db_xref="InterPro:IPR003777" /db_xref="InterPro:IPR027051" /db_xref="SubtiList:BG13992" /db_xref="UniProtKB/Swiss-Prot:O32147" /translation="MGNFHTMLDALLEDQEEAVLATIVQVEGSAYRKAGASMLFKKKG RRIGLLSGGCVEEDVFQRISALGDQLTSTLIPYDMRSEDDLSWGMGAGCNGIIHVHAE RITQEKRRHYEKVRDCLHSGKAVTSVIKIESSHYLFLTENGHFGNWPDAPLQDIQRTV STLHLPHFDQTTNMFIQRIEPKPRLILFGAGPDNVPLANLAADTGFSVIVTDWRPAYC TSSLFPKADQLITAFPEQMLSEFQFFPHDAAVVATHHYQHDQTIINFLFSQNLHYIGL LGSANRTKRLLSGKHPPSHFYSPVGLKIGAEGPEEIAVSVVAEIIQTRKRVAVV*" gene complement(3160452..3161444) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" S_feature complement(3161445..3161531) /Source="Nicolas_S_feature" /locus_tag="new_3340938_3341024_c" /HighExp="BT, Cold, Sw, T-1.10H, S1, C30, S0, T-0.40H, T-3.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.607" /TUlongSig="NA" /TUlongPSig="NA" /label="S1253" promotor_-10 complement(3161509..3161528) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3161531) /Source="Nicolas_upshifts" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" promotor_-35 complement(3161542..3161547) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3161673..3162923) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 20852637, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 20852637, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(S)-ureidoglycine-glyoxylate aminotransferase (PLP-dependent)" /protein_id="NP_391132.1" /db_xref="EnsemblGenomes-Gn:BSU32520" /db_xref="EnsemblGenomes-Tr:CAB15242" /db_xref="GOA:O32148" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR024169" /db_xref="PDB:3ISL" /db_xref="SubtiList:BG13993" /db_xref="UniProtKB/Swiss-Prot:O32148" /translation="MSGRRELCTPLRTIMTPGPVEVDPRVLRVMSTPVVGQFDPAFTG IMNETMEMLRELFQTKNRWAYPIDGTSRAGIEAVLASVIEPEDDVLIPIYGRFGYLLT EIAERYGANVHMLECEWGTVFDPEDIIREIKKVKPKIVAMVHGETSTGRIHPLKAIGE ACRTEDALFIVDAVATIGGCEVKVDEWKIDAAIGGTQKCLSVPSGMAPITYNERVADV IAARKKVERGIATQADRAALSGNRPITSNYFDLSQLEDYWSERRLNHHTEATTMLYAL REGVRLVLEEGLETRFERHRHHEAALAAGIKAMGLRLFGDDSCKMPVVTCVEIPGGID GESVRDMLLAQFGIEIASSFGPLAGKIWRIGTMGYSCRKENVLFVLAGLEAVLLRHNA GIEAGKALQAALDVYENAGRQAAV*" gene complement(3161673..3162923) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" CDS complement(3162940..3164178) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" /EC_number="3.5.3.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11344136, 17362992, 25020232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoate amidohydrolase" /protein_id="NP_391133.1" /db_xref="EnsemblGenomes-Gn:BSU32530" /db_xref="EnsemblGenomes-Tr:CAB15243" /db_xref="GOA:O32149" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010158" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13994" /db_xref="UniProtKB/Swiss-Prot:O32149" /translation="MEKQKLSVKNSITDYIEWLAQYGASADGGVTRLLYTKEWMDAQL AVKTEMSSFGLETRFDDVGNVFGRLSGTQSPDEVIVTGSHIDTVINGGKYDGAYGVLA AMLALKQLKETYGAPKKTLEAVSLCEEEGSRFPMTYWGSGNMTGVFSEQDAKEPRDES GVSLQTAMHESGFGKGVFQSAYRTDISAFVELHIEQGKTLEMSGRDLGIVTSIAGQRR YLVTLEGECNHAGTTSMKWRKDPLAASSRIIHELLLRSDELPDELRLTCGKITAEPNV ANVIPGRVQFSIDIRHQHQHVLEQFHQDMVALINGICLQKGIRAVIDEYMRIEPVPMD ERLKAAAFETALENGFSCEEMVSGAGHDAQMIGRRYPACMLFVPSRGGVSHSPKEYTS ARQLEIGVRALTDLLYKLAY*" gene complement(3162940..3164178) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" CDS 3164401..3164538 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514002.1" /translation="MNKLSWRGDVRGTDENRNAGSPQKQDLKIWKQEISASSKGTNLQ F*" gene 3164401..3164538 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" promotor_-35 3164560..3164563 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3164578..3164597 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3164579 /Source="Nicolas_upshifts" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" CDS 3164620..3165486 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1396690, 12490701, 12883447, 16291680, 25844442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1396690, 12490701, 12883447, 16291680, 25844442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular ribonuclease" /protein_id="NP_391134.1" /db_xref="EnsemblGenomes-Gn:BSU32540" /db_xref="EnsemblGenomes-Tr:CAB15244" /db_xref="GOA:O32150" /db_xref="InterPro:IPR007346" /db_xref="SubtiList:BG13995" /db_xref="UniProtKB/Swiss-Prot:O32150" /translation="MTKKAWFLPLVCVLLISGWLAPAASASAQTTLSLNDRLASSPSG TGSLLSLAAPAAPYADTDTYYEGAEGKTGDSLKSTLHRIISGHTMLSYSEVWNALKET DEDPRNPNNVILLYTNESRSKNLNGGNVGDWNREHVWAKSHGDFGTSKGPGTDIHHLR PADVQVNSARGNMDFDNGGTEYAKAPGNYYDGDSWEPRDDVKGDVARMLFYMAVRYEG DDGYPDLELNDKTGNGSAPYHGKQSVLLEWNKQDPVDDRERKRNEIIYEKYQHNRNPF IDHPEWADEIWP*" gene 3164620..3165486 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" downshifts 3165489 /Source="Nicolas_upshifts" /id="D1687" /incds=0 /nref=48 /ntot=190 /MaxReadThrough="0.45317" /MaxDrop="6.90997" /score="25.7790712" /energy="-15.5" /TU="NA" /idTUdmin="U2550" /TUdmin=8 /isTUend="TRUE" CDS complement(3165520..3166623) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23175651, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23175651, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid ABC transporter (ATP-bindingsubunit)" /protein_id="NP_391135.1" /db_xref="EnsemblGenomes-Gn:BSU32550" /db_xref="EnsemblGenomes-Tr:CAB15245" /db_xref="GOA:O32151" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR013611" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13996" /db_xref="UniProtKB/Swiss-Prot:O32151" /translation="MASLTFEHVKKSYHSQLTVKDFDLDVKDKELLVLVGPSGCGKST TLRMVAGLESISEGNLLIDGERVNDLPPKERDIAMVFQNYALYPHMTVFDNMAFGLKL RKMAKQEIAERVHAAARILEIEHLLKRKPKALSGGQRQRVALGRSIVREPKVFLMDEP LSNLDAKLRVTMRTEISKLHQRLEATIIYVTHDQTEAMTMGDRIVVMNEGEIQQVAKP HDIYHYPANLFVAGFIGSPGMNFLKGIIEQQHGELFFTNSSIRLHIPEEKAKRLKEKG YAGEQMIAGVRPEHITQMTGNDQLFDSVFQANVEVNENLGSELIVHVMAGDERLKVRL DGNTRIDAGDSIQLSVKMDHVVFFDAETEEAVY*" gene complement(3165520..3166623) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" downshifts complement(3165535) /Source="Nicolas_upshifts" /id="D1688" /incds=0 /nref=57 /ntot=215 /MaxReadThrough="3.04361" /MaxDrop="6.06171" /score="29.1144499" /energy="-15.5" /TU="NA" /idTUdmin="U2553" /TUdmin=0 /isTUend="TRUE" S_feature complement(3166624..3167557) /Source="Nicolas_S_feature" /locus_tag="new_3346117_3347050_c" /HighExp="HiOs, T-5.40H, T5.0H, GM-0.1, S2, GM-0.2, GM 5, T-4.40H, T4.0H, SMM" /AntisenseName="frlR" /AntisenseCor="0.22682293682100099" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.971, 0.456, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1254" promotor_-35 3166661..3166668 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3166682..3166701 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3166692 /Source="Nicolas_upshifts" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" promotor_-35 3166743..3166749 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3166760 /Source="Nicolas_upshifts" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" promotor_-10 3166764..3166783 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3166805..3167533 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" /experiment="publication(s) with functional evidences, PMID:21347729, 21398478, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21347729, 21398478, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FrlR transcriptional regulator (GntR family)" /protein_id="NP_391136.3" /db_xref="EnsemblGenomes-Gn:BSU32560" /db_xref="EnsemblGenomes-Tr:CAB15246" /db_xref="GOA:O32152" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2IKK" /db_xref="SubtiList:BG13997" /db_xref="UniProtKB/Swiss-Prot:O32152" /translation="MLNNGSSTPLYIQLKQIITDDIKKGVYSPTAKLPTENELCTKYN VSRITVRKAILDLVEEGYLIRQQGKGTFVKSPKLKRELIAVNGYSEFMESTGKKPKHH VLSHDIIPASKPIAEKLQIQPESPVVELKRILYNDDQPLTFEVTHYPLDLFPGIDTFI ADGVSMHDILKQQYKVVPTHNTKLLNVVYAQQEESKYLDCDIGDALFEIDKTAFTSND QPIYCSLFLMHTNRVTFTINSPYT*" gene 3166805..3167533 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" CDS complement(3167558..3168412) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 14641112, 15556630, 16153181, 21347729, 21398478, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fructoselysine kinase" /protein_id="NP_391137.1" /db_xref="EnsemblGenomes-Gn:BSU32570" /db_xref="EnsemblGenomes-Tr:CAB15247" /db_xref="GOA:O32153" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13998" /db_xref="UniProtKB/Swiss-Prot:O32153" /translation="MKLIAVGDNVVDYYQDQETFYPGGNALNVAVLAKRLGHESSYIG IVGNDEAAAHLLNVLKLEQVNADYIRQAHGENGMAIVTLDEQGDRIFVRSNKGGIQSR LRLAFQEKDVSFISGHDLLHTSVYSRLENDLPQLCGLVPVSFDFSTNREDDYLRRVCP YVTYAFFSGSDLSESECGELAKTAHGYGAKMVCMTRGGQGAILSAGDRVYHQPIVEAD IIDTLGAGDSFIAGFLTAFCVKQDITYALRQAAETAAKTCGVYGAFGYGYPYRLEDGG SSEKTRIL*" gene complement(3167558..3168412) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" misc_feature complement(3167745..3167764) /Source="Nicolas_upshift_promotors" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3167757) /Source="Nicolas_upshifts" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" promotor_no_box complement(3167915..3168015) /Source="Nicolas_upshift_promotors" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3167955) /Source="Nicolas_upshifts" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" CDS complement(3168426..3169328) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391138.1" /db_xref="EnsemblGenomes-Gn:BSU32580" /db_xref="EnsemblGenomes-Tr:CAB15248" /db_xref="GOA:O32154" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13999" /db_xref="UniProtKB/Swiss-Prot:O32154" /translation="MLPQKKTDSFRLEPVPDQHIEVKDKPRRKWYIGETSVWVFLFLY LIAIAYPLLWMVMSAFKNSDDIFEHSWSLPSSWHPENFVSAWNQGISSYFMNSVIVTA LTCVITVFISAWAAYGLSRFEFKGKGFFLVLCLGGLMLTPQVSLVPLYSIIQSLGLYN TYWALILPYAAYRIPFTIILIRSYFLSISKELEEAAYLDGCTSFGVFFRIFLPMSVPI LVTSGILTAYHTWNEFMFAIIFIDDENLRTIPAGLMQFRDALQTDWGVLLAGLTISAA PIIILFLLMQKYFVRGIASGSVKG*" gene complement(3168426..3169328) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" CDS complement(3169332..3170210) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391139.1" /db_xref="EnsemblGenomes-Gn:BSU32590" /db_xref="EnsemblGenomes-Tr:CAB15249" /db_xref="GOA:O32155" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14000" /db_xref="UniProtKB/Swiss-Prot:O32155" /translation="MVNQNKIIPYLFLVPALVFLLFVYIPIFENVFLSLFQWSSFSPE KTFIGLKNYVELFHDPVFYQALTNNVLYAVISIVCQVFGGLILAAVLEDKLVRKWSPF FRTVFFLPVVISMTVIALLFDFIYNPETGLLNQLLQAIGLDQLTRAWLGDDSTAMLSV IFVSQWQSVGYIAMLYIVSIQKIPDELYEAARLDGAGKIQQFFHITVPQTKEMSFVAV VMTLTGAFTVFNEPYILTGGGPGKASEVLSTFLYKSAFTKDMMGYASAIATVVLIITL ALSLMQMKFFKTGKEE*" gene complement(3169332..3170210) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" CDS complement(3170268..3171536) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 21347729; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose amino acid-binding lipoprotein" /protein_id="NP_391140.1" /db_xref="EnsemblGenomes-Gn:BSU32600" /db_xref="EnsemblGenomes-Tr:CAB15250" /db_xref="GOA:O32156" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG14001" /db_xref="UniProtKB/Swiss-Prot:O32156" /translation="MKKMLLFLIIAAVSMLTIAGCSSQSSSADGKVTLKFFHRWPKEP EKSYFEEVVKEFEKDHPDIDIQIEAVLNDSYKDKIKVMLGTTSPPDIYFSWSDEFAFK FIRGNKALDLSSYYKNDTDWSSQLVQSQITPFTYENKQYGVPWQMDAKSFFYNKDIFQ KLNLDPPKTWDELIDVSKKLKEHGYTPISFGTKATWTISHYIGTLNQRMVDEKTREKD YNAKTGEFTDEGYVKALEKLQELMPYFNKHVNSVDHEYVRQQFKSGKSAMIYAETAEI KLVEPVNLGMFPFPEISGQKGSSEALTGAPEGFMISSRTKHPKEAMEFLQFLTSKRMG EKLVKDVGKYSAVQGTATEENATAIQREAVQHIVDAKSMVPWFDMDVDVEVADAYLTG VQQMLGGDMTPQQVMKAVQKAAKQVRASAE*" gene complement(3170268..3171536) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" promotor_no_box 3171427..3171527 /Source="Nicolas_upshift_promotors" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3171487 /Source="Nicolas_upshifts" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts complement(3171607) /Source="Nicolas_upshifts" /id="D1689" /incds=0 /nref=21 /ntot=141 /MaxReadThrough="7.96763" /MaxDrop="4.994" /score="3.53212058" /energy="-13.8" /TU="U2557" /idTUdmin="U2558" /TUdmin=1210 /isTUend="FALSE" CDS complement(3171617..3172603) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12618455, 15556630, 16153181, 18083814, 21347729, 21398478, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructosamine-6-P deglycase" /protein_id="NP_391141.1" /db_xref="EnsemblGenomes-Gn:BSU32610" /db_xref="EnsemblGenomes-Tr:CAB15251" /db_xref="GOA:O32157" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR024713" /db_xref="InterPro:IPR035488" /db_xref="InterPro:IPR035490" /db_xref="PDB:3EUA" /db_xref="SubtiList:BG14002" /db_xref="UniProtKB/Swiss-Prot:O32157" /translation="MSQATAKVNREVQAFLQDLKGKTIDHVFFVACGGSSAIMYPSKY VFDRESKSINSDLYSANEFIQRNPVQLGEKSLVILCSHSGNTPETVKAAAFARGKGAL TIAMTFKPESPLAQEAQYVAQYDWGDEALAINTNYGVLYQIVFGTLQVLENNTKFEQA IEGLDQLQAVYEKALKQEADNAKQFAKAHEKESIIYTMASGANYGVAYSYSICILMEM QWIHSHAIHAGEYFHGPFEIIDESVPFIILLGLDETRPLEERALTFSKKYGKKLTVLD AASYDFTAIDDSVKGYLAPLVLNRVLRSYADELAEERNHPLSHRRYMWKVEY*" gene complement(3171617..3172603) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" upshifts 3172550 /Source="Nicolas_upshifts" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 3172553..3172557 /Source="Nicolas_upshift_promotors" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3172646..3172665) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3172659) /Source="Nicolas_upshifts" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" promotor_-35 complement(3172680..3172687) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3172817) /Source="Nicolas_upshifts" /id="D1690" /incds=0 /nref=116 /ntot=274 /MaxReadThrough="0.87627" /MaxDrop="5.35981" /score="3.53212058" /energy="-13.8" /TU="NA" /idTUdmin="U2558" /TUdmin=0 /isTUend="TRUE" CDS complement(3172819..3173193) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excinuclease" /protein_id="NP_391142.1" /db_xref="EnsemblGenomes-Gn:BSU32620" /db_xref="EnsemblGenomes-Tr:CAB15252" /db_xref="GOA:O32158" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR014527" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG14003" /db_xref="UniProtKB/Swiss-Prot:O32158" /translation="MIKIDIPAPNVTITERQQSANDNEPKIKPIHGFIDFHQIPRDKG GIFMFYNIHDELLFVGKARKLRQRIKKHFEDTVSPIKHHRDEVYKIEVCVVDDPMERE IYETYIINTQHSKYNIDKVFFK*" gene complement(3172819..3173193) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" upshifts complement(3173257) /Source="Nicolas_upshifts" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" promotor_-10 complement(3173264..3173275) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3173289..3173295) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3173296..3174414) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 13914427, 16245349, 22271930, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acid oxidase" /protein_id="NP_391143.1" /db_xref="EnsemblGenomes-Gn:BSU32630" /db_xref="EnsemblGenomes-Tr:CAB15253" /db_xref="GOA:O32159" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14004" /db_xref="UniProtKB/Swiss-Prot:O32159" /translation="MKSYIIVGAGILGASTAYHLAKTGARVTVIDRKEPGQATDAAAG IVCPWLSQRRNQDWYQLAKGGARYYKDLIHQLEKDGESDTGYKRVGAISIHTDASKLD KMEERAYKRREDAPEIGDITRLSASETKKLFPILADGYESVHISGAARVNGRALCRSL LSAAEKRGATVIKGNASLLFENGTVTGVQTDTKQFAADAVIVTAGAWANEILKPLGIH FQVSFQKAQIMHFEMTDADTGSWPVVMPPSDQYILSFDNGRIVAGATHENDAGLDDLR VTAGGQHEVLSKALAVAPGLADAAAVETRVGFRPFTPGFLPVVGAVPNVQGLYAANGL GASGLTMGPFLGAELAKLVLGKQTELDLSPYDPAGALA*" gene complement(3173296..3174414) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" promotor_-10 complement(3174439..3174458) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3174445) /Source="Nicolas_upshifts" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" S_feature complement(3174447..3175057) /Source="Nicolas_S_feature" /locus_tag="new_3353940_3354550_c" /HighExp="G135, H2O2, G180, Paraq, G150, Oxctl, LBGexp, Salt, dia15, Diami" /AntisenseName="yurS" /AntisenseCor="-0.14245591415946501" /AntisenseRegPval="-1.7" /CDS_PredictionProba="0.95340499999999995" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1255" promotor_-35 complement(3174472..3174478) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3174511..3174520 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3174534..3174553 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3174538 /Source="Nicolas_upshifts" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" promotor_-10 complement(3174551..3174566) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3174555) /Source="Nicolas_upshifts" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" promotor_-35 complement(3174573..3174577) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3174573..3174719 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type f : factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054592.1" /db_xref="EnsemblGenomes-Gn:BSU32640" /db_xref="EnsemblGenomes-Tr:CAE01466" /db_xref="GOA:Q7WY59" /db_xref="SubtiList:BG14173" /db_xref="UniProtKB/Swiss-Prot:Q7WY59" /translation="MSENRHENEENRRDAAVAKVQNSGNAKVVVSVNTDQDQAQAQSQ DGED*" gene 3174573..3174719 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" CDS 3174719..3174994 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9852018" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391144.1" /db_xref="EnsemblGenomes-Gn:BSU32650" /db_xref="EnsemblGenomes-Tr:CAB15254" /db_xref="SubtiList:BG14005" /db_xref="UniProtKB/Swiss-Prot:O32160" /translation="MNENIIPLNRHTQEIPTTESVIKNSGNSEVHIDIHIDTMPIAFA ILCSALAAKQMTKEEFDMAYTQLREMNRENNSRSSVKQIINQETEEE*" gene 3174719..3174994 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" upshifts complement(3174863) /Source="Nicolas_upshifts" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3174879..3174893) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3174902..3174906) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3174974 /Source="Nicolas_upshifts" /id="D1691" /incds=0 /nref=36 /ntot=86 /MaxReadThrough="1.84089" /MaxDrop="7.4989" /score="15.0184762" /energy="-11" /TU="NA" /idTUdmin="U2560" /TUdmin="-11" /isTUend="TRUE" CDS complement(3175058..3175441) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10882093, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10882093, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxalase; lactoylbacillithiol lyase" /protein_id="NP_391145.1" /db_xref="EnsemblGenomes-Gn:BSU32660" /db_xref="EnsemblGenomes-Tr:CAB15255" /db_xref="GOA:O32161" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG14006" /db_xref="UniProtKB/Swiss-Prot:O32161" /translation="MKIVVTSIFVQDQDMALEFYTEKLGFIKKEDVPMGKFRWITLVS PDDQDGTELLLEPNEHPAAKEYQKKIFSEGLPATMFGVADIQKEYNRLKEKGVTFTTE PTKMGEVTIAVFDDTCGNLIQIVQK*" gene complement(3175058..3175441) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" S_feature complement(3175442..3175551) /Source="Nicolas_S_feature" /locus_tag="new_3354935_3355044_c" /HighExp="Salt, G180, H2O2, Paraq, G135, G150, LBGexp, LBGstat, dia15, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1256" CDS complement(3175552..3175830) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="YP_003097781.1" /db_xref="EnsemblGenomes-Gn:BSU32669" /db_xref="EnsemblGenomes-Tr:CAX52687" /db_xref="GOA:C0H3Q8" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3Q8" /translation="MNGNKDAIFKALGDSTRRLILDELSERNELTLYELTIRLITKYD LSITRQAIAKHLSVLEDAGLVTSKRKGKYRVLIFNNEPLKNLLKGWIE*" gene complement(3175552..3175830) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" promotor_-10 complement(3175828..3175847) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3175852) /Source="Nicolas_upshifts" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" promotor_-35 complement(3175862..3175869) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3175993..3176099) /Source="Nicolas_S_feature" /locus_tag="new_3355486_3355592_c" /HighExp="Sw, BI, LPhT, C90, BC, M0t45, Gly, Cold, H2O2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.994" /TUlongSig="SigGF" /TUlongPSig="0.999" /label="S1257" downshifts complement(3176036) /Source="Nicolas_upshifts" /id="D1692" /incds=0 /nref=189 /ntot=303 /MaxReadThrough="3.22318" /MaxDrop="7.82118" /score="0.760415296" /energy="-10.1" /TU="U2564" /idTUdmin="U2565" /TUdmin="-7" /isTUend="TRUE" CDS complement(3176100..3177497) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16109955, 16431905, 16621837, 20097860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16109955, 16431905, 16621837, 20097860; Product type f: factor" /codon_start=1 /transl_table=11 /product="FeS cluster formation scaffold protein" /protein_id="NP_391146.1" /db_xref="EnsemblGenomes-Gn:BSU32670" /db_xref="EnsemblGenomes-Tr:CAB15256" /db_xref="GOA:O32162" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR010231" /db_xref="SubtiList:BG14007" /db_xref="UniProtKB/Swiss-Prot:O32162" /translation="MAKKMPDIGEYKYGFHDKDVSIFRSERGLTKEIVEEISRMKEEP QWMLDFRLKSLEHFYNMPMPQWGGDLNSLNFDEITYYVKPSERSERSWDEVPEEIKQT FDKLGIPEAEQKYLAGVSAQYESEVVYHNMKEDLEAQGIVFKDTDSALKENEDIFREH WAKVIPPTDNKFAALNSAVWSGGSFIYVPKGVKVETPLQAYFRINSENMGQFERTLII VDEEASVHYVEGCTAPVYTTNSLHSAVVEIIVKKGGYCRYTTIQNWANNVYNLVTKRT VCEENATMEWIDGNIGSKLTMKYPACILKGEGARGMTLSIALAGKGQHQDAGAKMIHL APNTSSTIVSKSISKQGGKVTYRGIVHFGRKAEGARSNIECDTLIMDNKSTSDTIPYN EILNDNISLEHEAKVSKVSEEQLFYLMSRGISEEEATEMIVMGFIEPFTKELPMEYAV EMNRLIKFEMEGSIG*" gene complement(3176100..3177497) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" downshifts 3177295 /Source="Nicolas_upshifts" /id="D1693" /incds=1 /nref=1 /ntot=150 /MaxReadThrough="2.66718" /MaxDrop="3.75483" /score="-4.89805724" /energy="-5" /TU="NA" /idTUdmin="U2560" /TUdmin=2310 /isTUend="FALSE" CDS complement(3177518..3177961) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16877383, 20097860, 21236255, 24321018, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16877383, 20097860, 21236255, 24321018, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="iron-sulfur cluster assembly sulfur-transfer protein (Zn(2+)-dependent)" /protein_id="NP_391147.1" /db_xref="EnsemblGenomes-Gn:BSU32680" /db_xref="EnsemblGenomes-Tr:CAB15257" /db_xref="GOA:O32163" /db_xref="InterPro:IPR002871" /db_xref="PDB:1XJS" /db_xref="PDB:2AZH" /db_xref="SubtiList:BG14008" /db_xref="UniProtKB/Swiss-Prot:O32163" /translation="MSFNANLDTLYRQVIMDHYKNPRNKGVLNDSIVVDMNNPTCGDR IRLTMKLDGDIVEDAKFEGEGCSISMASASMMTQAIKGKDIETALSMSKIFSDMMQGK EYDDSIDLGDIEALQGVSKFPARIKCATLSWKALEKGVAKEEGGN*" gene complement(3177518..3177961) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" CDS complement(3177951..3179171) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_391148.1" /db_xref="EnsemblGenomes-Gn:BSU32690" /db_xref="EnsemblGenomes-Tr:CAB15258" /db_xref="GOA:O32164" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR010970" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="PDB:5J8Q" /db_xref="SubtiList:BG14009" /db_xref="UniProtKB/Swiss-Prot:O32164" /translation="MNITDIREQFPILHQQVNGHDLVYLDSAATSQKPRAVIETLDKY YNQYNSNVHRGVHTLGTRATDGYEGAREKVRKFINAKSMAEIIFTKGTTTSLNMVALS YARANLKPGDEVVITYMEHHANIIPWQQAVKATGATLKYIPLQEDGTISLEDVRETVT SNTKIVAVSHVSNVLGTVNPIKEMAKIAHDNGAVIVVDGAQSTPHMKIDVQDLDCDFF ALSSHKMCGPTGVGVLYGKKALLENMEPAEFGGEMIDFVGLYESTWKELPWKFEAGTP IIAGAIGLGAAIDFLEEIGLDEISRHEHKLAAYALERFRQLDGVTVYGPEERAGLVTF NLDDVHPHDVATVLDAEGIAVRAGHHCAQPLMKWLDVTATARASFYLYNTEEEIDKLV EALQKTKEYFTNVF*" gene complement(3177951..3179171) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" CDS complement(3179171..3180484) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16109955, 16431905, 16621837, 19187533, 20097860, 28839209; Product type f: factor" /codon_start=1 /transl_table=11 /product="Fe-S cluster assembly protein SufD" /protein_id="NP_391149.1" /db_xref="EnsemblGenomes-Gn:BSU32700" /db_xref="EnsemblGenomes-Tr:CAB15259" /db_xref="GOA:O32165" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR011542" /db_xref="SubtiList:BG14010" /db_xref="UniProtKB/Swiss-Prot:O32165" /translation="MTLGTKLSVDQEYLKSFSEKHQEPAWLKNLRLQALEQAEDLPMP KPDKTKITNWNFTNFAKHTVDNEPLSSLEDLTDEVKALIDIENEDKTLYVQRDQTPAH LSLSQELKDKGVIFTDILTAAREHSDLVEKYFMKDGVKVDEHKLTALHAALVNGGAFL YVPKNVQVETPVQAVYVHESNDTALFNHVLIVAEDHSSVTYVENYISTVNPKDAVFNI ISEVITGDNASVTYGAVDNLSSGVTTYVNRRGAARGRDSKIEWALGLMNDGDTISENT TNLYGDGTYGDTKTVVVGRGEQTENFTTQIIHFGKASEGYILKHGVMKDSASSIFNGI GKIEHGASKANAEQESRVLMLSEKARGDANPILLIDEDDVTAGHAASVGRVDPIQLYY LMSRGIPKEEAERLVIYGFLAPVVNELPIEGVKKQLVSVIERKVK*" gene complement(3179171..3180484) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" CDS complement(3180502..3181287) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16431905, 20097860, 28839209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16431905, 20097860, 28839209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfur mobilizing ABC protein, ATPase" /protein_id="NP_391150.1" /db_xref="EnsemblGenomes-Gn:BSU32710" /db_xref="EnsemblGenomes-Tr:CAB15260" /db_xref="GOA:P80866" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010230" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14011" /db_xref="UniProtKB/Swiss-Prot:P80866" /translation="MAASTLTIKDLHVEIEGKEILKGVNLEIKGGEFHAVMGPNGTGK STLSAAIMGHPKYEVTKGSITLDGKDVLEMEVDERAQAGLFLAMQYPSEISGVTNADF LRSAINARREEGDEISLMKFIRKMDENMEFLEMDPEMAQRYLNEGFSGGEKKRNEILQ LMMIEPKIAILDEIDSGLDIDALKVVSKGINKMRSENFGCLMITHYQRLLNYITPDVV HVMMQGRVVKSGGAELAQRLEAEGYDWIKQELGIEDETVGQEA*" gene complement(3180502..3181287) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" promotor_-10 complement(3181331..3181350) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(3181332) /Source="Nicolas_upshifts" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" promotor_-35 complement(3181364..3181371) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" promotor_-10 complement(3181388..3181407) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(3181397) /Source="Nicolas_upshifts" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" S_feature complement(3181399..3181480) /Source="Nicolas_S_feature" /locus_tag="new_3360892_3360973_c" /HighExp="Salt, HiOs, B60, LoTm, T1.0H, Gly, T2.0H, C30, Etha, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1258" promotor_-35 complement(3181423..3181427) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" misc_RNA complement(3181444..3181691) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" /product="small regulatory RNA or messenger RNA" /experiment="publication(s) with functional evidences, PMID:18948176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176; Product type n: RNA" gene complement(3181444..3181691) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" CDS complement(3181481..3181618) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin antitoxin system" /protein_id="YP_003097782.1" /db_xref="EnsemblGenomes-Gn:BSU32719" /db_xref="EnsemblGenomes-Tr:CAX52688" /db_xref="UniProtKB/Swiss-Prot:C0H3Q9" /translation="MEKAMQLSHGIGYEEYGRRLETRMKVERQRELDYEKSKRISAGA Y*" gene complement(3181481..3181618) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" S_feature complement(3181619..3181703) /Source="Nicolas_S_feature" /locus_tag="new_3361112_3361196_c" /HighExp="HiOs, Salt, B60, S5, T1.0H, S8, HiTm, S7, T1.30H, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63415999999999995" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1259" promotor_-10 complement(3181687..3181706) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3181703) /Source="Nicolas_upshifts" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" S_feature complement(3181705..3181811) /Source="Nicolas_S_feature" /locus_tag="new_3361198_3361304_c" /HighExp="S8, S5, S7, S6, S4, BT, ferm, nit, S3, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1260" promotor_-35 complement(3181722..3181725) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3181812..3182189) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391151.1" /db_xref="EnsemblGenomes-Gn:BSU32720" /db_xref="EnsemblGenomes-Tr:CAB15261" /db_xref="GOA:O32166" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG14012" /db_xref="UniProtKB/Swiss-Prot:O32166" /translation="MEGFSLNQDRGSMQDALKQYKHGLGTFEQKMPLMGRKFNEFTEQ CFAGNSLTEREKQLIALGIAINAQDEYCMIYHTKGCLDQGASEENILEAVSVAAAFGG GAAFSQGVTVVQQCIEEFGNTTH*" gene complement(3181812..3182189) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" promotor_-10 complement(3182206..3182217) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-10" upshifts complement(3182212) /Source="Nicolas_upshifts" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" promotor_-35 complement(3182231..3182237) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-35" CDS complement(3182274..3183098) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 16109943, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 16109943, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, substrate binding lipoprotein" /protein_id="NP_391152.1" /db_xref="EnsemblGenomes-Gn:BSU32730" /db_xref="EnsemblGenomes-Tr:CAB15262" /db_xref="GOA:O32167" /db_xref="InterPro:IPR004872" /db_xref="PDB:4GOT" /db_xref="SubtiList:BG14013" /db_xref="UniProtKB/Swiss-Prot:O32167" /translation="MKKLFLGALLLVFAGVMAACGSNNGAESGKKEIVVAATKTPHAE ILKEAEPLLKEKGYTLKVKVLSDYKMYNKALADKEVDANYFQHIPYLEQEMKENTDYK LVNAGAVHLEPFGIYSKTYKSLKDLPDGATIILTNNVAEQGRMLAMLENAGLITLDSK VETVDATLKDIKKNPKNLEFKKVAPELTAKAYENKEGDAVFINVNYAIQNKLNPKKDA IEVESTKNNPYANIIAVRKGEEDSAKIKALMEVLHSKKIKDFIEKKYDGAVLPVSE*" gene complement(3182274..3183098) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" downshifts complement(3182282) /Source="Nicolas_upshifts" /id="D1694" /incds=0 /nref=167 /ntot=246 /MaxReadThrough="2.13581" /MaxDrop="6.33517" /score="28.8468637" /energy="-12.6" /TU="NA" /idTUdmin="U2569" /TUdmin="-5" /isTUend="TRUE" downshifts complement(3182431) /Source="Nicolas_upshifts" /id="D1695" /incds=1 /nref=2 /ntot=171 /MaxReadThrough="6.93658" /MaxDrop="2.3341" /score="28.8468637" /energy="-12.6" /TU="U2569" /idTUdmin="U2569" /TUdmin="-154" /isTUend="FALSE" promotor_-35 3182458..3182463 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3182479..3182497 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3182481 /Source="Nicolas_upshifts" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3183112..3183780) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 15849754, 16850406, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 15849754, 16850406, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, permease component" /protein_id="NP_391153.1" /db_xref="EnsemblGenomes-Gn:BSU32740" /db_xref="EnsemblGenomes-Tr:CAB15263" /db_xref="GOA:O32168" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14014" /db_xref="UniProtKB/Swiss-Prot:O32168" /translation="MFEKYFPNVDLTELWNATYETLYMTLISLLFAFVIGVILGLLLF LTSKGSLWQNKAVNSVIAAVVNIFRSIPFLILIILLLGFTKFLVGTILGPNAALPALV IGSAPFYARLVEIALREVDKGVIEAAKSMGAKTSTIIFKVLIPESMPALISGITVTAI ALIGSTAIAGAIGSGGLGNLAYVEGYQSNNADVTFVATVFILIIVFIIQIIGDLITNI IDKR*" gene complement(3183112..3183780) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" CDS complement(3183773..3184798) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 17038623; Product type t: transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter (ATP-binding protein)" /protein_id="NP_391154.1" /db_xref="EnsemblGenomes-Gn:BSU32750" /db_xref="EnsemblGenomes-Tr:CAB15264" /db_xref="GOA:O32169" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017908" /db_xref="InterPro:IPR018449" /db_xref="InterPro:IPR026253" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14015" /db_xref="UniProtKB/Swiss-Prot:O32169" /translation="MINLQDVSKVYKSKHGDVNAVQNVSLSIKKGEIFGIIGYSGAGK SSLIRLLNGLEKPTSGTVEVAGTKINEVNGRGLRKARHEISMIFQHFNLLWSRTVRDN IMFPLEIAGVKKSERIKRANELIKLVGLEGKEKSYPSQLSGGQKQRVGIARALANNPK VLLCDEATSALDPQTTDSILDLLSDINERLGLTIVLITHEMHVIRKICNRVAVMENGK VVEEGEVLDVFKNPKEQMTKRFVQQVTEPEETKETLQHLLDDTASGKMVQLTFVGESA EQPLITEMIRNFNVSVNILQGKISQTKDGAYGSLFIHIDGDEEEVQNVIRFINDKQVK AEVITNV*" gene complement(3183773..3184798) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" S_feature complement(3184799..3184903) /Source="Nicolas_S_feature" /locus_tag="new_3364292_3364396_c" /HighExp="MG 5, MG t5, MG 10, BMM, MG-0.2, GM 25, MG-0.1, MG 15, M9-exp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1261" misc_RNA complement(3184904..3185010) /gene="mswH" /locus_tag="BSU_misc_RNA_53" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" gene complement(3184904..3185010) /gene="mswH" /locus_tag="BSU_misc_RNA_53" downshifts 3184973 /Source="Nicolas_upshifts" /id="D1696" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="1.54417" /MaxDrop="5.51028" /score="-1.70178746" /energy="-11.2" /TU="NA" /idTUdmin="U2568" /TUdmin=2420 /isTUend="FALSE" promotor_-10 complement(3185037..3185056) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3185049) /Source="Nicolas_upshifts" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" S_feature complement(3185051..3185124) /Source="Nicolas_S_feature" /locus_tag="new_3364544_3364617_c" /HighExp="M9-stat, S2, LoTm, T5.0H, HiOs, B60, S3, T3.30H, LPhT, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1262" promotor_-35 complement(3185072..3185079) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3185125..3185469) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391155.1" /db_xref="EnsemblGenomes-Gn:BSU32760" /db_xref="EnsemblGenomes-Tr:CAB15265" /db_xref="InterPro:IPR003033" /db_xref="InterPro:IPR036527" /db_xref="SubtiList:BG14016" /db_xref="UniProtKB/Swiss-Prot:O32170" /translation="MEKAEVLEDEYQHLFLKPLLNASTLLITFQGEAEALTVSINEQG EMKKVSPPQTSNLTFYGNQTEIIDLLHGDISLQHLIQSGSLKVKGSFRALLKLEAILW LTNGFFQRILKN*" gene complement(3185125..3185469) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" S_feature complement(3185470..3185575) /Source="Nicolas_S_feature" /locus_tag="new_3364963_3365068_c" /HighExp="LPhT, HiOs, M9-stat, dia5, T2.0H, Diami, T1.30H, T0.30H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA, SigA" /TUshortPSig="1, 0.996, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S1263" CDS complement(3185576..3185896) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 25875741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_391156.1" /db_xref="EnsemblGenomes-Gn:BSU32770" /db_xref="EnsemblGenomes-Tr:CAB15266" /db_xref="GOA:O32171" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14017" /db_xref="UniProtKB/Swiss-Prot:O32171" /translation="MKELQEHELDHIEDDVYLLYLYTPFCGTCQLASKMLTVVKEMLP DVAFYQNNVNYSPTFAKAYQIESVPCFLLFKGGKMVERGYAFHSVSYLYELIKQKSSS ASHL*" gene complement(3185576..3185896) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" CDS complement(3185898..3186338) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12794188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease" /protein_id="NP_391157.1" /db_xref="EnsemblGenomes-Gn:BSU32780" /db_xref="EnsemblGenomes-Tr:CAB15267" /db_xref="GOA:O32172" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG14018" /db_xref="UniProtKB/Swiss-Prot:O32172" /translation="MLAVNFTAFFYNLNISNLTRQVNKMKMDELEKVMIVEGKSDKEK IESVLNEPMRIICTNGTISQLRLEELADELYDKDVYILVDADESGEKLRKQLKREFNE ACHLHVDRAYKEVAAAPRHHIASVLLRANLNVHTIFLERKSRGV*" gene complement(3185898..3186338) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" CDS complement(3186338..3186574) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391158.1" /db_xref="EnsemblGenomes-Gn:BSU32790" /db_xref="EnsemblGenomes-Tr:CAB15268" /db_xref="InterPro:IPR020140" /db_xref="SubtiList:BG14019" /db_xref="UniProtKB/Swiss-Prot:O32173" /translation="MAFDKQKLDVTNDVTGRFQNGRLSLYHDNEMIGQMTSMNEYELK SGYSFENEKFYKTADVVSGDDAKYVDCDYENGWC*" gene complement(3186338..3186574) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" downshifts complement(3186350) /Source="Nicolas_upshifts" /id="D1697" /incds=0 /nref=35 /ntot=245 /MaxReadThrough="6.00162" /MaxDrop="3.9147" /score="-1.53913693" /energy="-11" /TU="U2570,U2571,U2572" /idTUdmin="U2574" /TUdmin=723 /isTUend="FALSE" upshifts complement(3186589) /Source="Nicolas_upshifts" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" promotor_-10 complement(3186594..3186605) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3186620..3186626) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3186630..3187013) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 20882995, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine cleavage system protein H (lipoyl acceptor protein)" /protein_id="NP_391159.1" /db_xref="EnsemblGenomes-Gn:BSU32800" /db_xref="EnsemblGenomes-Tr:CAB15269" /db_xref="GOA:O32174" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR002930" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR017453" /db_xref="InterPro:IPR033753" /db_xref="SubtiList:BG14020" /db_xref="UniProtKB/Swiss-Prot:O32174" /translation="MSIPKDLRYSGEHEWVKVEGEKARIGITHFAQSELGDIVFVELP EVGAEIKADEPFGSVESVKTVSELYAPINGTVVEVNEDLDDSPEFVNESPYEKAWMIV VEPSDASEIEKLMTAEQYEEMTQED*" gene complement(3186630..3187013) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" promotor_-10 complement(3187040..3187059) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-10" upshifts complement(3187051) /Source="Nicolas_upshifts" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" promotor_-35 complement(3187072..3187079) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-35" CDS complement(3187080..3187436) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" /EC_number="1.20.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with thioredoxin domain and regulator domain" /protein_id="NP_391160.1" /db_xref="EnsemblGenomes-Gn:BSU32810" /db_xref="EnsemblGenomes-Tr:CAB15270" /db_xref="GOA:O32175" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14021" /db_xref="UniProtKB/Swiss-Prot:O32175" /translation="MSLTFYWYPKCGTCRKAKKWLEEHGKEINEIHIAEQPPSKEELK ALYEKSGLDLKKFFNTSGMKYRELNLKEKLYHMSEDEQLELLASDGMLIKRPLTTDGE KVTVGFKEDQFEENWA*" gene complement(3187080..3187436) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" promotor_-10 complement(3187459..3187478) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-10" upshifts complement(3187469) /Source="Nicolas_upshifts" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" promotor_-35 complement(3187492..3187497) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-35" CDS complement(3187547..3189331) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase (FAD dependent)" /protein_id="NP_391161.1" /db_xref="EnsemblGenomes-Gn:BSU32820" /db_xref="EnsemblGenomes-Tr:CAB15271" /db_xref="GOA:O32176" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG14022" /db_xref="UniProtKB/Swiss-Prot:O32176" /translation="MAKKAADVQKGGGFLIEDVTYDQMYTPEDFTDEHKMIAKTTEDY IEQDVLPHIDDIENHQFEHSVRLLKKAGELGLLGADVPEEYGGLGLDKISSALITEKF SRAGSFSLSYGAHVGIGSLPIVFFGSEEQKKKYLPGLASGEKIAAYALTEPGSGSDAL GAKTTAVLNEAGTHYVLTGEKQWITNSAFADVFVVYAKVDGDKFSAFIVEKEFPGVST GPEEKKMGIKGSSTRTLILDQAEVPKENLLGEIGKGHVIAFNILNIGRYKLAVGTIGA SKRVIELSAAYANQRRQFKTPIAGFSLTQEKIGTMASRLYAMESSVYRTVGLFEDNMS QFTAEDLKDGRQIAKSIAEYAIECSLNKVFGSETLDYIVDEGVQIHGGYGFMQEYEVE RAYRDSRINRIFEGTNEINRLIVPSTFLKKALKGELPLFEKAQSLQEELMMLMPEEPG SGVLEQEKYIVKQAKKIALFAAGLAAQKYGKAIDREQEILVNVADIVSNVYAMESAVL RTEKAIAAQGAEKAAQKVLYTEIFVQEAFNEIEAHAKESLIAMEEGDSLRMMLSALRK LTRVTPKNVIQKKREAAAGIFEAEKYTV*" gene complement(3187547..3189331) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" downshifts complement(3187557) /Source="Nicolas_upshifts" /id="D1698" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="4.78872" /MaxDrop="6.88218" /score="31.8022607" /energy="-16.4" /TU="U2574" /idTUdmin="U2576" /TUdmin=0 /isTUend="TRUE" CDS complement(3189346..3190521) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" /EC_number="2.3.1.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acyltransferase" /protein_id="NP_391162.1" /db_xref="EnsemblGenomes-Gn:BSU32830" /db_xref="EnsemblGenomes-Tr:CAB15272" /db_xref="GOA:O32177" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG14023" /db_xref="UniProtKB/Swiss-Prot:O32177" /translation="MKEAVIVSGARTPVGKAKKGSLATVRPDDLGAICVKETLKRAGG YEGNIDDLIIGCATPEAEQGLNMARNIGALAGLPYTVPAITVNRYCSSGLQSIAYAAE KIMLGAYDTAIAGGAESMSQVPMMGHVTRPNLALAEKAPEYYMSMGHTAEQVAKKYGV SREDQDAFAVRSHQNAAKALAEGKFKDEIVPVEVTVTEIGEDHKPMEKQFVFSQDEGV RPQTTADILSTLRPAFSVDGTVTAGNSSQTSDGAAAVMLMDREKADALGLAPLVKFRS FAVGGVPPEVMGIGPVEAIPRALKLAGLQLQDIGLFELNEAFASQAIQVIRELGIDEE KVNVNGGAIALGHPLGCTGTKLTLSLIHEMKRRNEQFGVVTMCIGGGMGAAGVFELC* " gene complement(3189346..3190521) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" CDS complement(3190532..3192901) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" /EC_number="1.1.1.35" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17189250, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase" /protein_id="NP_391163.2" /db_xref="EnsemblGenomes-Gn:BSU32840" /db_xref="EnsemblGenomes-Tr:CAB15273" /db_xref="GOA:O32178" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14024" /db_xref="UniProtKB/Swiss-Prot:O32178" /translation="MHKHIRKAAVLGSGVMGSGIAAHLANIGIPVLLLDIVPNDLTKE EEKKGLTKDSSEVRSRLSRQAMKKLLKQKPAPLTSAKNTSYITPGNLEDDAEKLKEAD WIIEVVVENLEVKKKIFALVDEHRKTGSIVSSNTSGISVQEMAEGRSDDFKAHFLGTH FFNPARYLKLLEIIPIKETDPDILKFMTAFGENVLGKGVVTAKDTPNFIANRIGTYGL LVTVQEMLKGGYQVGEVDSITGPLIGRPKSATFRTLDVVGLDTFAHVARNVYDKADGD EKEVFRIPSFMNDMLEKGWIGSKAGQGFYKKEGKTIYELDPVTLTYGERTKMKSPALE AAKQAKGTKAKMKALIYSDDRAGRLLWNITSQTLLYSAELLGEIADDIHAIDQAMKWG FGWELGPFEMWDAIGLKQSAEKLEQLGADMPGWIKEMLDKGNETFYIKENGTVFYYDR GEYRAVKENKKRIHLQALKETKGVIAKNSGASLIDLGDDVALLEFHSKSNAIGLDIIQ MIHKGLEETERNYKGLVIGNQGKNFCVGANLAMILMEVQDDNFLEVDFVIRRFQETMM KIKYSAKPVVAAPFGMTLGGGTEACLPAARIQAASEAYMGLVESGVGLIPGGGGNKEL YINHLRRGHDPMNAAMKTFETIAMAKVSASAQEAREMNILKETDQISVNQDHLLYDAK QLAASLYDTGWRPPVKEKVKVPGETGYAALLLGAEQMKLSGYISEHDFKIAKKLAYVI AGGKVPFGTEVDEEYLLEIEREAFLSLSGEAKSQARMQHMLVKGKPLRN*" gene complement(3190532..3192901) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" promotor_-35 3192320..3192325 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3192340..3192358 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3192343 /Source="Nicolas_upshifts" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3192969..3192988) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-10" upshifts complement(3192972) /Source="Nicolas_upshifts" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" S_feature complement(3192980..3193246) /Source="Nicolas_S_feature" /locus_tag="new_3372473_3372739_c" /HighExp="S8, S6, S7, BT, B36, G/S, B60, S5, Pyr, S3" /AntisenseName="yuzL" /AntisenseCor="0.77564732124057401" /AntisenseRegPval="-54.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1264" promotor_-35 complement(3193002..3193009) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-35" promotor_-35 3193027..3193033 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3193048..3193059 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3193070 /Source="Nicolas_upshifts" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" CDS 3193076..3193222 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17189250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097783.1" /db_xref="EnsemblGenomes-Gn:BSU32849" /db_xref="EnsemblGenomes-Tr:CAX52689" /db_xref="InterPro:IPR025625" /db_xref="UniProtKB/Swiss-Prot:C0H3R0" /translation="MVREKKNPSSAAVSAASVKGDAGPTQHYGGGKRTSQNQQYKKHN MGQS*" gene 3193076..3193222 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" S_feature 3193223..3194249 /Source="Nicolas_S_feature" /locus_tag="new_3372716_3373742" /HighExp="S8, S5, S7, S4, S6, nit, ferm, T5.0H, S3, LoTm" /AntisenseName="fadM" /AntisenseCor="0.80952501049450498" /AntisenseRegPval="-63" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1265" CDS complement(3193247..3194155) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" /EC_number="1.5.5.2" /function="3.2: Degradation" /experiment="publication(s) with functional evidences, PMID:17189250, 17536821, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 17536821, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline dehydrogenase 1" /protein_id="NP_391164.1" /db_xref="EnsemblGenomes-Gn:BSU32850" /db_xref="EnsemblGenomes-Tr:CAB15274" /db_xref="GOA:O32179" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG14025" /db_xref="UniProtKB/Swiss-Prot:O32179" /translation="MLRHVFLFLSQNKTLTKFAKAYGTRLGARRFVAGDTIESAVKTV KRLNRSGLCATIDYLGEYAASEKEANQVAEECKKAIQAIAEHQLNSELSLKLTSIGLD LSEELALTHLRAILSVAKQYDVAVTIDMEDYSHYEQTLSIYRQCKQEFEKLGTVIQAY LYRAAEDIRKMRDLKPNLRLVKGAYKESAAVAFPDKRGTDLHFQSLIKLQLLSGNYTA VATHDDDIIAFTKQLVAEHQIPASQFEFQMLYGIRPERQKELAKEGYRMRVYVPYGTD WFSYFMRRIAERPANAAFVLKGILKK*" gene complement(3193247..3194155) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" S_feature complement(3194156..3194678) /Source="Nicolas_S_feature" /locus_tag="new_3373649_3374171_c" /HighExp="S8, S6, S7, BT, B36, B60, G/S, Pyr, S5, SMMPr" /AntisenseName="yuzM" /AntisenseCor="0.77827902986544495" /AntisenseRegPval="-55.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1266" CDS 3194250..3194495 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097784.1" /db_xref="EnsemblGenomes-Gn:BSU32859" /db_xref="EnsemblGenomes-Tr:CAX52690" /db_xref="InterPro:IPR012347" /db_xref="UniProtKB/Swiss-Prot:C0H3R1" /translation="MDNQQQSQMPPSVISTKDHLYLNDMLNWNLLAMKKAHFMAQQCQ DQTLKQELDRVGHMHHDHYQRILKHLQPGQQQSGYIQ*" gene 3194250..3194495 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" CDS 3194508..3194840 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat-like protein" /protein_id="NP_391165.1" /db_xref="EnsemblGenomes-Gn:BSU32860" /db_xref="EnsemblGenomes-Tr:CAB15275" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG14026" /db_xref="UniProtKB/Swiss-Prot:O32180" /translation="MNQQNQKISNPQTPVPTTSEMNDRDFVNELLTTEKYMTTAYCTA LHEFSHESLYQDIQSIFDESQKAQRKLYDLMFQYGWYSVEAEDSQKLQQSYQKFQQTI QQQSPYQQ*" gene 3194508..3194840 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" promotor_-10 complement(3194661..3194680) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3194678) /Source="Nicolas_upshifts" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" promotor_-35 complement(3194694..3194703) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3194829 /Source="Nicolas_upshifts" /id="D1699" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="2.684" /MaxDrop="5.38418" /score="9.88876972" /energy="-10.2" /TU="NA" /idTUdmin="U2575" /TUdmin=0 /isTUend="TRUE" promotor_-35 3194901..3194908 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3194922..3194941 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3194933 /Source="Nicolas_upshifts" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" CDS 3194999..3195466 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12923086, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923086, 19286808; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family, low level antibiotic resistance)" /protein_id="NP_391166.1" /db_xref="EnsemblGenomes-Gn:BSU32870" /db_xref="EnsemblGenomes-Tr:CAB15276" /db_xref="GOA:O32181" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1S3J" /db_xref="SubtiList:BG14027" /db_xref="UniProtKB/Swiss-Prot:O32181" /translation="MKSADQLMSDIQLSLQALFQKIQPEMLESMEKQGVTPAQLFVLA SLKKHGSLKVSEIAERMEVKPSAVTLMADRLEQKNLIARTHNTKDRRVIDLSLTDEGD IKFEEVLAGRKAIMARYLSFLTEEEMLQAAHITAKLAQAAETDEKQNMKRGNG*" gene 3194999..3195466 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" CDS 3195463..3197088 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19286808; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_391167.1" /db_xref="EnsemblGenomes-Gn:BSU32880" /db_xref="EnsemblGenomes-Tr:CAB15277" /db_xref="GOA:O32182" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14028" /db_xref="UniProtKB/Swiss-Prot:O32182" /translation="MKMSKEGKQSKRTLLITGLIIAMFFSALDGTIVGTAMPKIVGDL GGLSMMTWLTTAYLLTSTTIVPIAGKLADLLGRRIVYVSGLIIFMAASALCGMANNMT ELIIFRGLQGIGGGIMMPMAMIVIGDLFTGKQRAKFQGVFGAIYGLASVIGPQIGGWI VDSLNWKWVFYINLPVGIIAVIFIARGLQGRQQTGPINFDIAGIFTMIVGVVSLLLAL SFGGKDYAWDSWQILGLFALALIGIVSFIIVESKAKEPILPMYLFKNRTFTFLNLIGF FMSIGMFGAITFVPFFMQGIVGVSASESGTIMTPMMISMIITSIIGGQLVYKIGIKPQ IITGMLVMAGGFLLLTTLDLDTSKLVATSFMAIIGLGMGLVMPILTLALQESFSKEEL GVVTSSSQFFRSIGGTFGITMLGAVMNARSGNLLTDKLVPYLDSLPAQASSFAAQLKG MIDTNPQGLLQSLFSPDAVKQIPAAFSSHIVPILKTSLMDSLHSVFYTGLIFIAVGAV FTLFLKPIKLSNKKAEDQQEKEKAAKAVESPSH*" gene 3195463..3197088 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" downshifts 3197073 /Source="Nicolas_upshifts" /id="D1700" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="0.3188" /MaxDrop="5.64223" /score="42.0555168" /energy="-17.7" /TU="NA" /idTUdmin="U2577" /TUdmin=0 /isTUend="TRUE" CDS complement(3197124..3197507) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" /EC_number="5.3.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25219626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydratase of unidentified specificity (tautomerase superfamily)" /protein_id="NP_391168.1" /db_xref="EnsemblGenomes-Gn:BSU32890" /db_xref="EnsemblGenomes-Tr:CAB15278" /db_xref="GOA:O32183" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG14029" /db_xref="UniProtKB/Swiss-Prot:O32183" /translation="MPFVQIHLRSGRSEVWLQKLSRTIHQSMIEEINVPEDDYFQVIR QYEKSEFFYDPFYLQVERTDELIYIHFTLKQSRTTEQKKALYRSIASRIHSELGVRKE DVFIMLAGNQDEDWSFGNGRAQMIE*" gene complement(3197124..3197507) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" CDS complement(3197526..3197915) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15294834; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_391169.1" /db_xref="EnsemblGenomes-Gn:BSU32900" /db_xref="EnsemblGenomes-Tr:CAB15279" /db_xref="GOA:O32184" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14030" /db_xref="UniProtKB/Swiss-Prot:O32184" /translation="MKGMFFCARAVVPFMKKSKDGAIVNVGSIAGITGAGSSMPYAVS KSAVHGLTKSLAHALAPEIRVSGVAPGAVATRWWAGREEKMKSMIGSLLLQCIAEPDD VAKLICSLIEQESLTGQIITIDSGQTL*" gene complement(3197526..3197915) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" CDS complement(3197937..3198266) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved enzyme of unknown function" /protein_id="NP_391170.1" /db_xref="EnsemblGenomes-Gn:BSU32910" /db_xref="EnsemblGenomes-Tr:CAB15280" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14031" /db_xref="UniProtKB/Swiss-Prot:O32185" /translation="MNVLNKIALVTGGGTGIGKAASMELAKRGAIVAVNYSRSQSEAE ETVEMIQKAGGQAFAIQADVSKNSDVQDMIQAIVNTHGTVDILVNNASITRHIPMDDL EAATEDV*" gene complement(3197937..3198266) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" promotor_-10 complement(3198301..3198320) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3198308..3198315 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3198315) /Source="Nicolas_upshifts" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 3198330..3198349 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3198334..3198341) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3198340 /Source="Nicolas_upshifts" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" CDS 3198400..3199287 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591, 17526699, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591, 17526699, 27965289; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown specificity(LysR family)" /protein_id="NP_391171.1" /db_xref="EnsemblGenomes-Gn:BSU32920" /db_xref="EnsemblGenomes-Tr:CAB15281" /db_xref="GOA:O32186" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14032" /db_xref="UniProtKB/Swiss-Prot:O32186" /translation="MESGDLRVFQMVAREGTITKAALQLGYVQSNVTARIQQLEAELG TTLFLRHNRGMTLSASGKLLLDYANKIIGLLDEASKALSSSAEPSGPLMIGCTQTTAA VRLPKLLASYYEEHPNVQLSLTTGHTQFLLDKVLRYELDGAFIGCECHHPELESYPAF EEEPVVVSAASVPDVEEAITKPILVYSTGCSYRETLEKWLRSVGVTQPVIMEFGTLEA IIGGVTAGLGISLLPRTVVQKHEAEGSIRLYPLPEALSQMKTEFIVRKDSFISSALRT FMDSFTPVKTAESQKSSLL*" gene 3198400..3199287 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" CDS complement(3199307..3199594) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22078549" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391172.1" /db_xref="EnsemblGenomes-Gn:BSU32930" /db_xref="EnsemblGenomes-Tr:CAB15282" /db_xref="InterPro:IPR020393" /db_xref="SubtiList:BG14033" /db_xref="UniProtKB/Swiss-Prot:O32187" /translation="MRKLLAVFSKGRWKMEQKLQEQLDGLLEKYTELLLGETNDELKE EVKQWILYTHIAKSMPPLAKHWNATYPDAKQGIKEIIQHIKELNEAHRNKQ*" gene complement(3199307..3199594) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" downshifts complement(3199319) /Source="Nicolas_upshifts" /id="D1701" /incds=0 /nref=113 /ntot=280 /MaxReadThrough="1.05563" /MaxDrop="5.97768" /score="17.1690128" /energy="-13.2" /TU="NA" /idTUdmin="U2580" /TUdmin="-14" /isTUend="TRUE" CDS complement(3199619..3200446) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 24847778, 25288929; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III)-siderophore transporter (ATP binding component)" /protein_id="NP_391173.1" /db_xref="EnsemblGenomes-Gn:BSU32940" /db_xref="EnsemblGenomes-Tr:CAB15283" /db_xref="GOA:O32188" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14034" /db_xref="UniProtKB/Swiss-Prot:O32188" /translation="MGMSAISTETLSLGYGDAVIIDELNLTIPKGEITVFIGSNGCGK STLLRSLARLMKPRGGSVLLEGRAIAKLPTKEVAKELAILPQGPSAPEGLTVHQLVKQ GRYPYQNWLKQWSKEDEEAVERALKATKLEDMADRAVDSLSGGQRQRAWIAMTLAQET DIILLDEPTTYLDMTHQIEILDLLFELNEKEDRTIVMVLHDLNLACRYAHHLVAIKDK RIYAEGRPEEVITCDLVQNVFSMNCQVTQDPLFGTPLCIPHGRGRCIVQEAAFTSHG* " gene complement(3199619..3200446) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" downshifts complement(3199635) /Source="Nicolas_upshifts" /id="D1702" /incds=0 /nref=2 /ntot=77 /MaxReadThrough="5.36684" /MaxDrop="3.19022" /score="11.3999731" /energy="-19.8" /TU="U2580" /idTUdmin="U2581" /TUdmin=220 /isTUend="FALSE" S_feature complement(3200447..3200584) /Source="Nicolas_S_feature" /locus_tag="new_3379940_3380077_c" /HighExp="T-5.40H, Paraq, H2O2, GM-0.2, HiOs, GM 5, dia15, GM 25, T-3.40H, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1267" promotor_-10 complement(3200569..3200588) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3200584) /Source="Nicolas_upshifts" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" promotor_-35 complement(3200604..3200607) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3200664..3201101) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26497467; Product type m : membrane component" /codon_start=1 /transl_table=11 /product="spore lipoprotein" /protein_id="NP_391174.1" /db_xref="EnsemblGenomes-Gn:BSU32950" /db_xref="EnsemblGenomes-Tr:CAB15284" /db_xref="InterPro:IPR025623" /db_xref="SubtiList:BG14035" /db_xref="UniProtKB/Swiss-Prot:O32189" /translation="MHLIRAAGAVCLAVVLIAGCRFNEDQHQAEGENTAVTQLKSVPY SNFSLRVSYGDGEHNRYEGIYTKNGTQEKAEIQDKLSGVNQEGEEALDEMKMILSELS VTDQMAETEVIHSVLAAFNLDSHYDHIDLKLKLKDGSIREIKK*" gene complement(3200664..3201101) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" promotor_-10 complement(3201125..3201143) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-10" upshifts complement(3201131) /Source="Nicolas_upshifts" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" promotor_-35 complement(3201159..3201164) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-35" CDS complement(3201211..3202719) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /EC_number="3.4.24.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; C-terminal part of YusY" /db_xref="SubtiList:BG14037" /translation="GLMNRLSADFQSSLVTLDHKLVDINQDVWNELLTKPGLRDVSYI LNERRQRVAEKLSPGKEKLIGNLAVDGYHAWSDLYNMVVGKMTIPYEENGENKQLSVG QAENMMDHQDRTVRKTVYERFRQAWESKQDIFSSTLNHLAGFRLETYKARGWENVLKE PLQINRMKKETLDTMWQVITENKKPFVQFLNRKASMLGLEKLSWYDVEAPIGSDGKVY SYDEAANIITSQFSTFGKKLSSFTEKAFRDGWIEAEDRSGKRVGGFCTSFPDSGESRI FMTFSGSASNVSTLAHELGHAFHQEAMLNVRPLNRSYAMNVAETASTFAEMIVADATV QQAETREEKLVLLEDKVQRSVAFFMNIHARFLFETRFYEERKRGVVPASRLNELMEEA QREAYCNALEEYHPLFWASKLHFHITRVPFYNFPYTFGYLFSLGIYALALEEKDTFEE KYMALLRDTASMTVEDLAMKHLGADITKRDFWENAIKLAVRDAETFLQMTES*" gene complement(3201211..3202719) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /pseudo downshifts complement(3201232) /Source="Nicolas_upshifts" /id="D1703" /incds=0 /nref=125 /ntot=240 /MaxReadThrough="2.57385" /MaxDrop="6.5698" /score="6.83314975" /energy="-12" /TU="NA" /idTUdmin="U2582" /TUdmin="-13" /isTUend="TRUE" CDS complement(3202710..3203006) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; N-terminal part of YusY" /translation="MALQGVGQRWDLDSFFKGGSQSEEFKGYIEKLSQSLRAFQDRTD AFQVPESPEEAEGLTALLDLFEQTSVKLQQAGAFVACLQAQNINDQKAIEHQAS*" gene complement(3202710..3203006) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /pseudo promotor_-10 complement(3203029..3203048) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3203045) /Source="Nicolas_upshifts" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" promotor_-35 complement(3203063..3203066) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3203083..3203088 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3203100..3203119 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3203100 /Source="Nicolas_upshifts" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" CDS 3203140..3203982 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative short-chain acyl dehydrogenase" /protein_id="NP_391177.1" /db_xref="EnsemblGenomes-Gn:BSU32980" /db_xref="EnsemblGenomes-Tr:CAB15287" /db_xref="GOA:P37959" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10863" /db_xref="UniProtKB/Swiss-Prot:P37959" /translation="MNKKIAIVTGASSGFGLLAAVKLARSFFVIATSRQPEKAEQLRE LAAAHNVSDSIHITALDVTDEQSIVSFGKAVSAYAPIDLLVNNAGTAYGGFIEDVPME HFRQQFETNVFGVIHVTKTVLPYIRKHGGAKIINVSSISGLTGFPALSPYVSSKHALE GFSESLRIELLPFGIETALIEPGSYKTSIWSTSLSNFMSVPADDSAYHQYYKKILSYV QKNGEESGDPQEVADLIYQLATKQHIKNLRYPIGKGIKLTLLFRSLFPWSAWESILKK KLFS*" gene 3203140..3203982 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" promotor_-35 3203512..3203518 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-35" promotor_-10 3203533..3203544 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-10" upshifts 3203541 /Source="Nicolas_upshifts" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" promotor_-35 3204009..3204016 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3204025 /Source="Nicolas_upshifts" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" promotor_-10 3204028..3204047 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3204072..3204533 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 8709848, 21057011, 22194458, 24123749, 28434086" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 8709848, 21057011, 22194458, 24123749, 28434086; Product type f : factor" /codon_start=1 /transl_table=11 /product="metalloregulation DNA-binding stress protein" /protein_id="NP_391178.1" /db_xref="EnsemblGenomes-Gn:BSU32990" /db_xref="EnsemblGenomes-Tr:CAB15288" /db_xref="GOA:P37960" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="PDB:2CHP" /db_xref="SubtiList:BG10864" /db_xref="UniProtKB/Swiss-Prot:P37960" /translation="MKTENAKTNQTLVENSLNTQLSNWFLLYSKLHRFHWYVKGPHFF TLHEKFEELYDHAAETVDTIAERLLAIGGQPVATVKEYTEHASITDGGNETSASEMVQ ALVNDYKQISSESKFVIGLAEENQDNATADLFVGLIEEVEKQVWMLSSYLG*" gene 3204072..3204533 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" downshifts 3204509 /Source="Nicolas_upshifts" /id="D1704" /incds=0 /nref=234 /ntot=274 /MaxReadThrough="1.7919" /MaxDrop="8.26581" /score="36.5549876" /energy="-13.3" /TU="NA" /idTUdmin="U2583" /TUdmin=0 /isTUend="TRUE" CDS complement(3204577..3205953) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423; Product type f: factor" /codon_start=1 /transl_table=11 /product="protease-associated chaperone for the extracytoplasmic folding and quality control of exported proteins" /protein_id="NP_391180.2" /db_xref="EnsemblGenomes-Gn:BSU33000" /db_xref="EnsemblGenomes-Tr:CAB15290" /db_xref="GOA:Q9R9I1" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14155" /db_xref="UniProtKB/Swiss-Prot:Q9R9I1" /translation="MDYRRDGQNDQHQTEPSHTEQQNTENQKLIGHSEQELLDAPVSY EAGRQETASALEMEKQETAVKKEKKRRAAWLSPILGGIIGGGLMLGIAPYLPSDQNQA TETASANKQVQSDNFTTAPITNASNIADMVEDLEPTIVGISNIQTSQNNTFGTGGGSS SESESGTGSGVIFKKDSDKAYIITNNHVVEGANKLTVTLYNGETETAKLVGSDTITDL AVLEISGKNVKKVASFGDSSQLRTGEKVIAIGNPLGQQFSGTVTQGIISGLNRTIDVD TTQGTVEMNVLQTDAAINPGNSGGPLINASGQVIGINSLKVSESGVESLGFAIPSNDV EPIVDQLLQNGKVDRPFLGVQMIDMSQVPETYQENTLGLFGDQLGKGVYVKEVQANSP AEKAGIKSEDVIVKLNGKDVESSADIRQILYKDLKVGDKTTIQVLRKGKTKTLNATLT KQTESSSS*" gene complement(3204577..3205953) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" downshifts complement(3204585) /Source="Nicolas_upshifts" /id="D1705" /incds=0 /nref=206 /ntot=257 /MaxReadThrough="1.84997" /MaxDrop="6.39104" /score="17.1953741" /energy="-11.2" /TU="U2586" /idTUdmin="U2586" /TUdmin="-22" /isTUend="TRUE" S_feature complement(3205954..3206125) /Source="Nicolas_S_feature" /locus_tag="new_3385447_3385618_c" /HighExp="SMMPr, T-0.40H, T-1.10H, M9-tran, T-1.40H, T1.0H, T0.30H, T1.30H, Etha, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67259999999999998" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1268" promotor_-10 complement(3206106..3206125) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3206125) /Source="Nicolas_upshifts" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" promotor_-35 complement(3206136..3206143) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3206186..3206205) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-10" misc_feature 3206196..3206215 /Source="Nicolas_upshift_promotors" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3206198 /Source="Nicolas_upshifts" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" upshifts complement(3206204) /Source="Nicolas_upshifts" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" S_feature complement(3206206..3207269) /Source="Nicolas_S_feature" /locus_tag="new_3385699_3386762_c" /HighExp="T1.0H, T0.30H, T1.30H, C30, T2.0H, G135, G180, T2.30H, ferm, G150" /AntisenseName="cssR" /AntisenseCor="0.115381389160342" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1269" promotor_-35 complement(3206220..3206227) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-35" CDS 3206231..3206908 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type r: regulator" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component response regulator" /protein_id="NP_391181.1" /db_xref="EnsemblGenomes-Gn:BSU33010" /db_xref="EnsemblGenomes-Tr:CAB15291" /db_xref="GOA:O32192" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14131" /db_xref="UniProtKB/Swiss-Prot:O32192" /translation="MSYTIYLVEDEDNLNELLTKYLENEGWNITSFTKGEDARKKMTP SPHLWILDIMLPDTDGYTLIKEIKAKDPDVPVIFISARDADIDRVLGLELGSNDYISK PFLPRELIIRVQKLLQLVYKEAPPVQKNEIAVSSYRVAEDAREVYDENGNIINLTSKE FDLLLLFIHHKGHPYSREDILLKVWGHDYFGTDRVVDDLVRRLRRKMPELKVETIYGF GYRMMSS*" gene 3206231..3206908 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" CDS 3206905..3208260 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component sensor histidine kinase" /protein_id="NP_391182.2" /db_xref="EnsemblGenomes-Gn:BSU33020" /db_xref="EnsemblGenomes-Tr:CAB15292" /db_xref="GOA:O32193" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14132" /db_xref="UniProtKB/Swiss-Prot:O32193" /translation="MKNKPLAFQIWVVISGILLAISILLLVLFSNTLRDFFTNETYTT IENEQHVLTEYRLPGSIERRYYSEEATAPTTVRSVQHVLLPENEEASSDKDLSILSSS FIHKVYKLADKQEAKKKRYSADVNGEKVFFVIKKGLSVNGQSAMMLSYALDSYRDDLA YTLFKQLLFIIAVVILLSWIPAIWLAKYLSRPLVSFEKHVKRISEQDWDDPVKVDRKD EIGKLGHTIEEMRQKLVQKDETERTLLQNISHDLKTPVMVIRGYTQSIKDGIFPKGDL ENTVDVIECEALKLEKKIKDLLYLTKLDYLAKQKVQHDMFSIVEVTEEVIERLKWARK ELSWEIDVEEDILMPGDPEQWNKLLENILENQIRYAETKIEISMKQDDRNIVITIKND GPHIEDEMLSSLYEPFNKGKKGEFGIGLSIVKRILTLHKASISIENDKTGVTYRIAVP K*" gene 3206905..3208260 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" S_feature complement(3207359..3208287) /Source="Nicolas_S_feature" /locus_tag="new_3386852_3387780_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, ferm, C30, LPhT, T-1.10H, Lbstat" /AntisenseName="cssS" /AntisenseCor="0.27217686232372901" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigD, SigH, SigA" /TUshortPSig="1, 0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1270" downshifts 3208228 /Source="Nicolas_upshifts" /id="D1706" /incds=0 /nref=61 /ntot=203 /MaxReadThrough="0.95076" /MaxDrop="4.47937" /score="13.0972324" /energy="-9.7" /TU="NA" /idTUdmin="U2587" /TUdmin=1 /isTUend="TRUE" CDS complement(3208288..3208452) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" /experiment="publication(s) with functional evidences, PMID:21378193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21378193; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpxA degradation" /protein_id="YP_003097785.1" /db_xref="EnsemblGenomes-Gn:BSU33029" /db_xref="EnsemblGenomes-Tr:CAX52691" /db_xref="GOA:O32302" /db_xref="UniProtKB/Swiss-Prot:O32302" /translation="MRELDEMISRLRNRGIKVEKVKYPKQTLSEKKWVHQCKQPLKTN YRDFNGYSFT*" gene complement(3208288..3208452) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" promotor_-35 3208476..3208483 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3208497..3208516 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3208501..3208520) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3208507..3208619 /Source="Nicolas_S_feature" /locus_tag="new_3388000_3388112" /HighExp="dia5, Diami, T0.30H, T-0.40H, T0.0H, dia15, Salt, ferm, G135, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1271" upshifts 3208507 /Source="Nicolas_upshifts" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" upshifts complement(3208514) /Source="Nicolas_upshifts" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" S_feature complement(3208516..3208794) /Source="Nicolas_S_feature" /locus_tag="new_3388009_3388287_c" /HighExp="Etha, Gly, S2, Glucon, Pyr, G/S, S1, Lbstat, Cold, HiTm" /AntisenseName="yuxN" /AntisenseCor="-0.128326996122899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigH, SigA" /TUshortPSig="0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1272" promotor_-35 complement(3208534..3208541) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3208620..3209495 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391183.1" /db_xref="EnsemblGenomes-Gn:BSU33030" /db_xref="EnsemblGenomes-Tr:CAB15293" /db_xref="GOA:P40950" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG11072" /db_xref="UniProtKB/Swiss-Prot:P40950" /translation="MKEKEKLIIETALKLFAQKGYNSTSVQEIAKECKISKGAFYIYF PSKEALLLSMLNYYYDKTFTRILNIKTKGDSPRTAYRKQLTVLYENILEHKDFISMQL KEGSLPYTEEVEQCAKKIRQSSLQFHIDSLLNIYGKKAEPYTAELCFLIEGISQIYLE CMILLGYTVKPSQLADIIMNRIDDMVKGMSERNDKPFITLEEASSLFGPLTHGRPDPL TESIVKSLRDKINSLNTNSSLELSESLDILEAEMKKKTPKLAIIKGMIHNLTESEALA KDAEQLKYLLKQQHI*" gene 3208620..3209495 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" promotor_-10 complement(3208784..3208803) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3208794) /Source="Nicolas_upshifts" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" S_feature complement(3208796..3209337) /Source="Nicolas_S_feature" /locus_tag="new_3388289_3388830_c" /HighExp="LBGstat, Cold, S2, Glucon, S1, Pyr, G/S, C30, GM 10, GM-0.1" /AntisenseName="yuxN" /AntisenseCor="-0.341746670828522" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigH, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1273" promotor_-35 complement(3208817..3208824) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3209329..3209347) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3209337) /Source="Nicolas_upshifts" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" S_feature complement(3209339..3209468) /Source="Nicolas_S_feature" /locus_tag="new_3388832_3388961_c" /HighExp="S2, S1, G/S, Glucon, Pyr, T3.30H, M9-stat, BT, Cold, T4.0H" /AntisenseName="yuxN" /AntisenseCor="-0.30886083736579201" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1274" promotor_-35 complement(3209360..3209367) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3209470 /Source="Nicolas_upshifts" /id="D1707" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="3.14099" /MaxDrop="3.7614" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2589" /TUdmin="-11" /isTUend="TRUE" downshifts complement(3209513) /Source="Nicolas_upshifts" /id="D1708" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="5.30537" /MaxDrop="3.29426" /score="-2.73895091" /energy="-13.6" /TU="U2593,U2594" /idTUdmin="U2591" /TUdmin="-1584" /isTUend="FALSE" CDS complement(3209531..3210919) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" /EC_number="4.2.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:2509422, 3130545, 3923430, 9647666, 22914898, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509422, 3130545, 3923430, 9647666, 22914898, 28032445; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fumarate hydratase" /protein_id="NP_391184.1" /db_xref="EnsemblGenomes-Gn:BSU33040" /db_xref="EnsemblGenomes-Tr:CAB15294" /db_xref="GOA:P07343" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR005677" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10384" /db_xref="UniProtKB/Swiss-Prot:P07343" /translation="MEYRIERDTMGEVKVPADKFWGAQTQRSKENFKIGSEKMPMRVV KAFAILKRSTALANKRLGNLDAEKAEAIAAVCDDVLKGKYDDNFPLVVWQTGSGTQSN MNMNEVVANRATALLKEKNSDQTIHPNDDVNRSQSSNDTFPTAMHVAAVLAVYEQLVP ALDQLRNTLDEKAKAYNDIVKIGRTHLQDATPLTLGQEISGWVHMLDRSKEMILEATD KMRALAIGGTAVGTGINAHPEFGELVSEEITKLTGQTFSSSPNKFHALTSHDEITYAH GALKALAADLMKIANDVRWLASGPRCGIGEIVIPENEPGSSIMPGKVNPTQSEALTMI AAQIMGNDATIGFAASQGNFELNVFKPVIIYNFLQSVQLLSDGMNSFHDKCAVGIEPN KETIQENLSNSLMLVTALNPHIGYENAAKIAKLAHKEGLTLKEAALKLELLTEEQFNE MVKPEDMVKPKA*" gene complement(3209531..3210919) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" upshifts complement(3210943) /Source="Nicolas_upshifts" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" promotor_-10 complement(3210948..3210966) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3210977..3210985) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3210986..3211171) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097786.1" /db_xref="EnsemblGenomes-Gn:BSU33049" /db_xref="EnsemblGenomes-Tr:CAX52692" /db_xref="InterPro:IPR025088" /db_xref="UniProtKB/Swiss-Prot:C0H3R3" /translation="MAQVRLAGKQEEIEQLIRSFEQHYDVSYTSKEYGRTNPKYKYSK DSRVYLELKLKSAKIEK*" gene complement(3210986..3211171) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" downshifts 3211175 /Source="Nicolas_upshifts" /id="D1709" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="1.13377" /MaxDrop="4.4478" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2595" /TUdmin="-748" /isTUend="FALSE" promotor_-10 complement(3211215..3211234) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3211224..3211230 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3211229) /Source="Nicolas_upshifts" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" promotor_-10 3211244..3211255 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3211247 /Source="Nicolas_upshifts" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" promotor_-35 complement(3211250..3211253) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3211289..3212737 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the GerA germination receptor" /protein_id="NP_391185.2" /db_xref="EnsemblGenomes-Gn:BSU33050" /db_xref="EnsemblGenomes-Tr:CAB15295" /db_xref="GOA:P07868" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10385" /db_xref="UniProtKB/Swiss-Prot:P07868" /translation="MEQTEFKEYIHDNLALVLPKLKENDDLVKNKKMLANGLVFYYLY FSEMTDENKVSEAIKTLIKDEETLTLDQVKKRLDQLDARPVETAKKTIESILNGNCAV FINGLDKAYILTTGKKKTRSLTEPTTEKVVRGPKVAFVEDIDTNLALIRQRTSHPKLI TKKIMIGENKLKPAAIMYIEGKAKKSVIKEVKARLKNIQLEDIQDSGTLEELIEDNKY SPFPQIQNTERPDKVSSALFNGRVAILVDSSPFVLLVPVSLGILMQSPDDYYERWISA SLIRSLRFASIFITLFLSSIYITLVSFHQGLLPTALAVTISANRENVPFPPIFEALLM EVTIELLREAGLRLPNPLGQTIGLVGGVVIGQAAVEANLVSSILVIVVSVIALASFTV PQYGMGLSFRVLRFISMFSAAILGLYGIILFMLVVYTHLTRQTSFGSPYFSPNGFFSL KNTDDSIIRLPIKNKPKEVNNPNEPKTDSTET*" gene 3211289..3212737 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" S_feature complement(3212285..3214928) /Source="Nicolas_S_feature" /locus_tag="new_3391778_3394421_c" /HighExp="Cold, H2O2, G135, G180, Paraq, G150, Oxctl, T-5.40H, LBGstat, T-4.40H" /AntisenseName="gerAC" /AntisenseCor="-9.7163861003102397E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1275" CDS 3212706..3213803 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16740944, 16850406, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16740944, 16850406, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA; putative transporter" /protein_id="NP_391186.1" /db_xref="EnsemblGenomes-Gn:BSU33060" /db_xref="EnsemblGenomes-Tr:CAB15296" /db_xref="GOA:P07869" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG10386" /db_xref="UniProtKB/Swiss-Prot:P07869" /translation="MSQKQTPLKLNTFQGISIVANTMLGAGLLTLPRALTTKANTPDG WITLILEGFIFIFFIYLNTLIQKKHQYPSLFEYLKEGLGKWIGSIIGLLICGYFLGVA SFETRAMAEMVKFFLLERTPIQVIILTFICCGIYLMVGGLSDVSRLFPFYLTVTIIIL LIVFGISFKIFDINNLRPVLGEGLGPIANSLTVVSISFLGMEVMLFLPEHMKKKKYTF RYASLGFLIPIILYILTYIIVVGALTAPEVKTLIWPTISLFQSFELKGIFIERFESFL LVVWIIQFFTTFVIYGYFAANGLKKTFGLSTKTSMVIIGITVFYFSLWPDDANQVMMY SDYLGYIFVSLFLLPFILFFIVALKRRITTK*" gene 3212706..3213803 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" CDS 3213800..3214921 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA" /protein_id="NP_391187.1" /db_xref="EnsemblGenomes-Gn:BSU33070" /db_xref="EnsemblGenomes-Tr:CAB15297" /db_xref="GOA:P07870" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG10387" /db_xref="UniProtKB/Swiss-Prot:P07870" /translation="MKIRILCMFICTLLLSGCWDSENIEELSLVIGIGLDKPDDENLE LTQQILVPKIISAKEGSSSDPTQLSITKGKTVHQMMRTSALKHKPTFSQHLRLILLSK SVIADQIGMDAIINQFVRDNGTRRSSYVFITNGRTKDIFNMNDEGEPASNVIYDLTEN NKVTIRTMEPVTLGEISEHLTSDDSFLIPHVGKENGKLAINGASIIKNKLWHRDLTPI EVQNISLFSGTVEGGVIDLKRDGHLFSYEVYSSNRKIKTAYKDGKFKFTVTRNIEGRL SEDWNPNEDSFKDSYIKSIEKTVEKRVHETVTSFITEKLQKEIKADVTGLGNEVRIHY PQKWKKISRKWDDDYFSNAEIDYRVNVIVRDFGTKGANK*" gene 3213800..3214921 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" CDS complement(3214929..3215564) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvqE] responding to cell wall stress" /protein_id="NP_391188.1" /db_xref="EnsemblGenomes-Gn:BSU33080" /db_xref="EnsemblGenomes-Tr:CAB15298" /db_xref="GOA:O32197" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14133" /db_xref="UniProtKB/Swiss-Prot:O32197" /translation="MIRVLLIDDHEMVRMGLAAFLEAQPDIEVIGEASDGSEGVRLAV ELSPDVILMDLVMEGMDGIEATKQICRELSDPKIIVLTSFIDDDKVYPVIEAGALSYL LKTSKAAEIADAIRAASKGEPKLESKVAGKVLSRLRHSGENALPHESLTKRELEILCL IAEGKTNKEIGEELFITIKTVKTHITNILSKLDVSDRTQAAVYAHRNHLVN*" gene complement(3214929..3215564) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" CDS complement(3215542..3216624) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" /function="16.12: Sense" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LiaR(YvqC)] sensing cell wall stress" /protein_id="NP_391189.1" /db_xref="EnsemblGenomes-Gn:BSU33090" /db_xref="EnsemblGenomes-Tr:CAB15299" /db_xref="GOA:O32198" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR017202" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14134" /db_xref="UniProtKB/Swiss-Prot:O32198" /translation="MRKKMLASLQWRAIRMTTGISLLLFVCLISFMMFYYRLDPLVLL SSSWFGIPFILILLLISVTVGFASGYMYGNRLKTRIDTLIESILTFENGNFAYRIPPL GDDEIGLAADQLNEMAKRVELQVASLQKLSNERAEWQAQMKKSVISEERQRLARDLHD AVSQQLFAISMMTSAVLEHVKDADDKTVKRIRMVEHMAGEAQNEMRALLLHLRPVTLE GKGLKEGLTELLDEFRKKQPIDIEWDIQDTAISKGVEDHLFRIVQEALSNVFRHSKAS KVTVILGIKNSQLRLKVIDNGKGFKMDQVKASSYGLNSMKERASEIGGVAEVISVEGK GTQIEVKVPIFPEEKGENERDSSIID*" gene complement(3215542..3216624) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" CDS complement(3216621..3217346) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane component associated to the LiaRS two-component system" /protein_id="NP_391190.1" /db_xref="EnsemblGenomes-Gn:BSU33100" /db_xref="EnsemblGenomes-Tr:CAB15300" /db_xref="GOA:O32199" /db_xref="InterPro:IPR016975" /db_xref="InterPro:IPR024425" /db_xref="SubtiList:BG14135" /db_xref="UniProtKB/Swiss-Prot:O32199" /translation="MTKKQLLGLIIALFGISMFLQIIGIGDLLFWPLFFLIAGYFLKK YSRDWLGSVMYIFAAFLFLKNLFSITFNLFGYAFAAFLIYAGYRLIKGKPIFEPNEKQ VNLNKKEHHEPPKDVKHPDMRSFFIGELQMMKQPFDLNDLNVSGFIGDIKIDLSKAMI PEGESTIVISGVIGNVDIYVPSDLEVAVSSAVFIGDINLIGSKKSGLSTKVYAASTDF SESKRRVKVSVSLFIGDVDVKYV*" gene complement(3216621..3217346) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" CDS complement(3217380..3218252) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="sensor of antibiotic stress on the cell wall" /protein_id="NP_391191.2" /db_xref="EnsemblGenomes-Gn:BSU33110" /db_xref="EnsemblGenomes-Tr:CAB15301" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14136" /db_xref="UniProtKB/Swiss-Prot:O32200" /translation="MKKMLGKLLITAGILVFFAVVVKDVFAAGLGFINGTEADSASAS PRDIDSMVIESDSKDVRIIAEERSDISAGISGDSGKLFVTENKRKLELTVKEKEFQFL NGFNRSTLIVRLPYDYKGDLAVRTSSGDVSVAGNDHLALSGLNAVSASGNTSVTDVRI QDLKVKASSGDVSISNTVSKTAGIDLASGDANLVHVSGSLDVKMTSGDFNAVLKKVTG PVSVTLTSGDANVSLPQNGSFAVNALSASGDVSSPYSFADKGHKEQHHITGTQGSGRH PIDIKTDSGDLAIR*" gene complement(3217380..3218252) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" promotor_-10 complement(3218271..3218290) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3218291) /Source="Nicolas_upshifts" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" promotor_-35 complement(3218305..3218308) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3218353..3219030) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23874669, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23874669, 24666271, 28546427; Product type f: factor" /codon_start=1 /transl_table=11 /product="modulator of liaIHGFSR (yvqIHGFEC) operon expression" /protein_id="NP_391192.1" /db_xref="EnsemblGenomes-Gn:BSU33120" /db_xref="EnsemblGenomes-Tr:CAB15302" /db_xref="GOA:O32201" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG14137" /db_xref="UniProtKB/Swiss-Prot:O32201" /translation="MVLKRIRDMFVASVHEGLDKMENPKVMLNQYVRDMESDIAKAKQ TIVKQHTIAYQFKKKYEEAAEVAGKRKNQAQLAFDAGEEELAKKALTEMKYLEGKAAE HKASYEQANSQLADLKEQLAALETKLQDVKDKKQALIARANAAKAKEHMNTTFDKIDS ESAYREFLRIENRIEEMEIRANYSKSAEAGTELTRKEFADDVEAEIEKMRTLSLQKSD QTKAANE*" gene complement(3218353..3219030) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" downshifts complement(3218369) /Source="Nicolas_upshifts" /id="D1710" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="3.84852" /MaxDrop="3.1352" /score="-8.3477012" /energy="-4.5" /TU="U2597" /idTUdmin="U2598" /TUdmin=1243 /isTUend="FALSE" CDS complement(3219057..3219437) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427; Product type s: structure" /codon_start=1 /transl_table=11 /product="membrane anchor for the phage-shock protein A homolog LiaH" /protein_id="NP_391193.1" /db_xref="EnsemblGenomes-Gn:BSU33130" /db_xref="EnsemblGenomes-Tr:CAB15303" /db_xref="GOA:O32202" /db_xref="SubtiList:BG14138" /db_xref="UniProtKB/Swiss-Prot:O32202" /translation="MKINKKTIGGFLLIVFGISVFFGGGSFGFIIPLAIGSLMTYAGI KRFAAGKTITGIIVGGIGAIMLICSLPFVVGIALAAAMVYYGWKLMKNGSADNGVSSF DPEPASAAYQSHFDDEWEEFLKKK*" gene complement(3219057..3219437) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" promotor_-10 complement(3219460..3219479) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3219480) /Source="Nicolas_upshifts" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" promotor_-35 complement(3219494..3219497) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3219599..3220867) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15273097, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux protein" /protein_id="NP_391194.1" /db_xref="EnsemblGenomes-Gn:BSU33140" /db_xref="EnsemblGenomes-Tr:CAB15304" /db_xref="GOA:O32203" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14139" /db_xref="UniProtKB/Swiss-Prot:O32203" /translation="MVNLIESDSIWKRNFNYLFFSRIVKISGDMFAFNSILWFLIYDG KGAIGTALLIAVTFLPEAVLAPVTGPFMKQTTLKFWMYFSDLTRAAIVLIIPLCHFAG FSPLWFVMTLMIVHSATGAAYNPASIALIPQIVNEQGIQKANAVLQSSAQIVRLGAVT LCGAFLTFISPSYTMLIALVLYLVSGFLVLFIKYTAVESQSESAVVTQRGTYIGRLKR GFRLVRKHQILYPLAIYCIFMNFAAAPWEALSAVYVAEDLNGQPIVYSLLKATTAAGA FLLGFVLAKVKVNRYGLLFVTAGIIEGFAFFITGMNTFLPLVFFAAFTFGAAVSAVNV PEYTIIQTSVDSEDQPQVYAVIHMISNISIPAGAVICGYAANAFGSGKVIAVGGIVEI IAGIGILLFTKLAKAERSDLIKEREASVHL*" gene complement(3219599..3220867) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" downshifts complement(3219612) /Source="Nicolas_upshifts" /id="D1711" /incds=0 /nref=78 /ntot=164 /MaxReadThrough="0.70612" /MaxDrop="4.80625" /score="32.7496145" /energy="-12.9" /TU="NA" /idTUdmin="U2598" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3220901..3220920) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3220912) /Source="Nicolas_upshifts" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" promotor_-35 complement(3220935..3220942) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3221038) /Source="Nicolas_upshifts" /id="D1712" /incds=0 /nref=33 /ntot=211 /MaxReadThrough="1.54601" /MaxDrop="4.92923" /score="51.1311697" /energy="-17.1" /TU="NA" /idTUdmin="U2599" /TUdmin=4 /isTUend="TRUE" CDS complement(3221044..3221625) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" /EC_number="2.5.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12869542, 14704351, 17588214, 19933577, 21514283; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP:cob(I)alamin adenosyltransferase" /protein_id="NP_391195.2" /db_xref="EnsemblGenomes-Gn:BSU33150" /db_xref="EnsemblGenomes-Tr:CAB15305" /db_xref="GOA:O34899" /db_xref="InterPro:IPR016030" /db_xref="InterPro:IPR029499" /db_xref="InterPro:IPR036451" /db_xref="PDB:1RTY" /db_xref="SubtiList:BG14140" /db_xref="UniProtKB/Swiss-Prot:O34899" /translation="MKLYTKTGDKGQTGLVGGRTDKDSLRVESYGTIDELNSFIGLAL AELSGQPGFEDLTAELLTIQHELFDCGGDLAIVTERKDYKLTEESVSFLETRIDAYTA EAPELKKFILPGGSKCASLLHIARTITRRAERRVVALMKSEEIHETVLRYLNRLSDYF FAAARVVNARSGIGDVEYERSAIVFRDRNSSES*" gene complement(3221044..3221625) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" CDS complement(3221648..3222976) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 transport system, ATPase component" /protein_id="NP_391196.1" /db_xref="EnsemblGenomes-Gn:BSU33160" /db_xref="EnsemblGenomes-Tr:CAB15306" /db_xref="GOA:O34631" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14141" /db_xref="UniProtKB/Swiss-Prot:O34631" /translation="MKAEGLSGGYGDSRLINNVSLTVEKGEFLGILGPNGSGKTTLLH LLTGTLPAKKGRVYLAGKLLADYKPKELAQIMAVLPQKMDQAFTFTVEETVAFGRYPF QTGLFRQQTEKGEAIVQEAMEQTGVADFAQKPIRELSGGEQQRVYLAQALAQQPRILF LDEPTNFLDLAYQKDLLDLIKRLTRESGLAAVSVFHDLNTASLYCDGLMFMKNGTAGP KQKPEYAVTEQSIKAVYDTDVTALVHQSSPKPMIVIQPEKDSVKRQSIPFEALLQAGR DDILLQTEIPLRTLSSTPIGAGFSWSRTLIHKRLPDQPDPIEGLTACLSESGFQLQET CAMASSERLDRFVYRTYEDGELSVFICVQTGFSIWILINGYAADQFFIKALMAAEAER TKVLGDGGGTGDILIAATQTQQSENIEQRLNQLIKKGTAECIKEAAELFE*" gene complement(3221648..3222976) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" CDS complement(3222976..3224037) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 15849754, 16850406, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 permease" /protein_id="NP_391197.1" /db_xref="EnsemblGenomes-Gn:BSU33170" /db_xref="EnsemblGenomes-Tr:CAB15307" /db_xref="GOA:O34451" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG14142" /db_xref="UniProtKB/Swiss-Prot:O34451" /translation="MRKAFTRIRLRNNRYAAYIIGFSFLAVSIILGISCGSLHIPIPA VFRVFWHQGFGGSIGSDDPMYTNIMMNIRLPRVVLAALVGAALSIAGAAFQGLLKNPL ADPYTLGVSSGASVGAVVTLFLGLHLPVIGGFTLPVLSVAAALATMAAVLFFSRLVHA SMSVSTLILTGVITNSFLGAFISLIIALTGDNLLPIVHWLLGSVSMRGWSYVILFLPF FLLGTILLIINGRELNVMTYGEDKAKLLGVSVQQRKMMILIAGSLLTGSAVAVSGTIG FVGLVIPHITRLLWGTDHRHLLPLSALLGAGFLVLADLLSRTIIEPIELPIGIITSLA GAPVFALILIRQHRGGRSL*" gene complement(3222976..3224037) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" CDS complement(3224000..3224944) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative lipoprotein binding vitamin B12" /protein_id="NP_391198.1" /db_xref="EnsemblGenomes-Gn:BSU33180" /db_xref="EnsemblGenomes-Tr:CAB15308" /db_xref="GOA:O34805" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG14143" /db_xref="UniProtKB/Swiss-Prot:O34805" /translation="MKKRAGIWAALLLAAVMLAGCGNPADQKDSKAKQKTEVFPVTID DASNQDVTIKKEPKKIVSLMPSNTEITYALGLGDKVVGVTTNDTYPKEVKKVEKVGDM NVNVEKVISLKPDLVLAHESSMSASADAIKQLKDAGITVLTVNDAQSFSEVYKSIEMI GEAGGAEKKADQLVKSMKSDLKDIQEKAKTISKDEEKSVFIEVSPDPDIYTTGKDTFM NEMLNVIHAKNAAADQTGWVQMTDEAIVKLNPDAIVTTDGVKAKAVEKRDGWSEINAV KHHRVYDVDPDLVTRSGPRLIEGVEELAESIYPDTFKE*" gene complement(3224000..3224944) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" S_feature complement(3224945..3225214) /Source="Nicolas_S_feature" /locus_tag="new_3404438_3404707_c" /HighExp="LBGtran, LBGexp, Etha, LPh, S3, Lbexp, G180, dia0, HPh, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.956, 1" /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1276" misc_RNA complement(3225053..3225183) /gene="srbL" /locus_tag="BSU_misc_RNA_85" /product="putative coenzyme B12 (AdoCbl) riboswitch" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 17038623, 21140903, 25917914; Product type n: RNA" /function="16.3: Control" gene complement(3225053..3225183) /gene="srbL" /locus_tag="BSU_misc_RNA_85" promotor_-10 complement(3225191..3225210) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3225214) /Source="Nicolas_upshifts" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" S_feature complement(3225216..3226143) /Source="Nicolas_S_feature" /locus_tag="new_3404709_3405636_c" /HighExp="Etha, B60, Sw, M9-stat, B36, C30, C90, Salt, G135, Gly" /AntisenseName="yvrD" /AntisenseCor="1.5286196477289399E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1277" promotor_-35 complement(3225226..3225233) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3225276..3225283 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3225298..3225317 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3225302 /Source="Nicolas_upshifts" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" CDS 3225342..3226133 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9922248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391199.1" /db_xref="EnsemblGenomes-Gn:BSU33190" /db_xref="EnsemblGenomes-Tr:CAB15309" /db_xref="GOA:O34782" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14144" /db_xref="UniProtKB/Swiss-Prot:O34782" /translation="MDLQLKEKLVLITGSTSGIGKAAAKSFLQEGAAVIVNGRKQETV DRTIEELSGYGTVHGAAADLSKTDEAAAFIEKVNEIGDIDILVNNLGFFEVKDFADVT DEEWNQYFEVNVMSAVRTSRHFLPKMLAKNSGRILNIASEAGVKPLPTMIPYSMTKTA LISLSRGMAEMTKGTNVTVNSVLPGPTWTEGVASYMEGAAQAAGQDTDTFIKDYFKVN EPTSLIQRYATAEEVANTIVFLASDAASAINGTAQRVEGGIIRSL*" gene 3225342..3226133 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" downshifts 3226004 /Source="Nicolas_upshifts" /id="D1713" /incds=1 /nref=2 /ntot=89 /MaxReadThrough="6.202" /MaxDrop="3.35017" /score="36.8938178" /energy="-12" /TU="U2600" /idTUdmin="U2600" /TUdmin="-110" /isTUend="FALSE" downshifts 3226114 /Source="Nicolas_upshifts" /id="D1714" /incds=0 /nref=105 /ntot=218 /MaxReadThrough="2.44739" /MaxDrop="6.33457" /score="36.8938178" /energy="-12" /TU="NA" /idTUdmin="U2600" /TUdmin=0 /isTUend="TRUE" CDS complement(3226171..3227049) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar lactone lactonase" /protein_id="NP_391200.1" /db_xref="EnsemblGenomes-Gn:BSU33200" /db_xref="EnsemblGenomes-Tr:CAB15310" /db_xref="GOA:O34940" /db_xref="InterPro:IPR005511" /db_xref="InterPro:IPR011042" /db_xref="InterPro:IPR013658" /db_xref="SubtiList:BG14145" /db_xref="UniProtKB/Swiss-Prot:O34940" /translation="MDAVLEADTRAVIGEGPLWDEENGRLYWVDILGSELHIFDPEEK INRSIKFKSFVTALAKYSKDELIMTMKDGFYLYHLRDDSLEKIKQPKDMHESLRFNDA KCDPYGRLWAGTTSMEGEQKQASLYRLNLDGSLVKIKDQVSTSNGLDWDRERNLMYYI DTPTQEIVRYSYDPQSGDVSNPEPVYRFDQSDGLPDGMTIDQNGMLWVALFGGSRVVH IDPFQKKEINSISVPAKYVTCCAFGGRDLKTLYITTATEQMTEKERYEQPHAGGLFSA QLETGGYQPVPFAGDV*" gene complement(3226171..3227049) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" downshifts complement(3226188) /Source="Nicolas_upshifts" /id="D1715" /incds=0 /nref=31 /ntot=260 /MaxReadThrough="7.17016" /MaxDrop="5.74101" /score="29.8014794" /energy="-12" /TU="U2601" /idTUdmin="U2602" /TUdmin="-20" /isTUend="TRUE" promotor_-10 complement(3227073..3227091) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3227092) /Source="Nicolas_upshifts" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" promotor_-35 complement(3227105..3227111) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3227121..3228863) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrH)]" /protein_id="NP_391201.2" /db_xref="EnsemblGenomes-Gn:BSU33210" /db_xref="EnsemblGenomes-Tr:CAB15311" /db_xref="GOA:O34989" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14146" /db_xref="UniProtKB/Swiss-Prot:O34989" /translation="MRLRWKFLFHFFGQMLIVILLLTVMLVASFFYLDARFSDAESNS GLTKATTDTLEAYLDVNEDGTWEVDNFLKKSVDKQHGWMQIIDSEGNTDYSYGVPKDV PGTYTKKELLSIYKTKKLHNYKLNYWAINIEDKSYLLLSGWKSKSEQLLTSVEKREQK IDSLAHYKSSTIDYIKRKKGAIYLLDSNGKILDSINSTKSERKTMNQLELLKYSSKPW NYKREISVKILNKDRWMVATVPNPVYVTDQEFNKSFLKVVLKAMFLVMAVLFMYIIWM TVWYMFRFGLPIFHTIRWLVNLSKGKLEEPRNREGRPVSKNKKGKIKQPYRFFGEIFE SMDQLTETLRRDKRNREKIQATREEWIAGLSHDLKTPLSSIYGYSMMLESKQYDWSPE EVKEMGQVVREKSEYMSKLIEDLNLTYRLKNDALPIERKLTSLIPFFKNVIEDFKKNP FSEGYDISFVSKEEHIEFALDEAWFRRILENLLGNAVKHNGKGTEIQVILEQTKNHIS LKVKDNGKGMDEETITHLFNRYYRGTNTKDSTAGTGLGLAIAKELVHLHNGTIHVNSR TNIGTVITILFKKQ*" gene complement(3227121..3228863) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" CDS complement(3228860..3229573) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrG)]" /protein_id="NP_391202.2" /db_xref="EnsemblGenomes-Gn:BSU33221" /db_xref="EnsemblGenomes-Tr:CAB15312" /db_xref="GOA:P94504" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12452" /db_xref="UniProtKB/Swiss-Prot:P94504" /translation="MENASILIVDDEKAIVDMIKRVLEKEGYRNILDAASAEEAIPVV KANKVDLIVLDVMMGGMSGFEACTLIREYSDAPIFFLTARSSDADKLSGFAVGADDYI TKPFNPLELAARIRAHLKRTYQSKETSSNQTYTYDYFTFSPQNAELIVGGEAVACSAQ LLQLLQYFCEHPNVVLSKDQIYEKVWGYPSYGDNNTVMVHIRKLREKIERDPSNPEYI VTVRGLGYRFIPNPEGKRS*" gene complement(3228860..3229573) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" misc_feature complement(3229604..3229623) /Source="Nicolas_upshift_promotors" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3229622) /Source="Nicolas_upshifts" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" CDS complement(3229726..3229965) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sigma-O" /protein_id="YP_003097787.1" /db_xref="EnsemblGenomes-Gn:BSU33222" /db_xref="EnsemblGenomes-Tr:CAX52693" /db_xref="GOA:C0H3R4" /db_xref="UniProtKB/Swiss-Prot:C0H3R4" /translation="MDGQFEQKKKQKDETYDIEHLIACFSPMIRKKLSNTSYQEREDL EQELKIKMFEKADMLLCQDVPGFWEFILYMVDENS*" gene complement(3229726..3229965) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" downshifts complement(3229733) /Source="Nicolas_upshifts" /id="D1716" /incds=0 /nref=4 /ntot=30 /MaxReadThrough="2.45068" /MaxDrop="3.82244" /score="12.6471586" /energy="-8.2" /TU="NA" /idTUdmin="U2605" /TUdmin="-5" /isTUend="TRUE" promotor_-10 complement(3229961..3229979) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3229969..3230499) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16306698, 18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16306698, 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="alternative sigma factor" /protein_id="NP_391203.2" /db_xref="EnsemblGenomes-Gn:BSU33230" /db_xref="EnsemblGenomes-Tr:CAB15313" /db_xref="GOA:O34843" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14147" /db_xref="UniProtKB/Swiss-Prot:O34843" /translation="MKHPIVKHFLSNPQHYRLFKNVMESPNEKDARSLDELFKQFYKE IRIVKYMNSMIRIFSIDFDKRVRKNQKRYPLTVDHPEAGDRLSSETGSDAFEEFLDRQ DDLSQHVQDYQLYQAIQKLTDKQKSVLTKVYLHGATMQEIADSLGESRQNISNIHKKG LENIRKQLAAQKKGEK*" gene complement(3229969..3230499) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" upshifts complement(3229970) /Source="Nicolas_upshifts" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" promotor_-35 complement(3229994..3230000) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3230502..3230521) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3230509) /Source="Nicolas_upshifts" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" CDS 3230514..3230852 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in oxalate decarboxylase expression" /protein_id="YP_003097788.1" /db_xref="EnsemblGenomes-Gn:BSU33239" /db_xref="EnsemblGenomes-Tr:CAX52694" /db_xref="InterPro:IPR024419" /db_xref="UniProtKB/Swiss-Prot:C0H3R5" /translation="MTVKDFDSPSNRLPTKLNEGKQKKVNYYFPPSVFQNTLQQFTFY RFSSLTYMTAEKEGRYFPMDQVFIEEVVKQIGNLGFPALIAMYLLTRFEKKFDQLIEL MTELKDHAKK*" gene 3230514..3230852 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" promotor_-35 complement(3230536..3230543) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3230552..3230571) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3230564) /Source="Nicolas_upshifts" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" promotor_-35 complement(3230586..3230592) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 3230598..3230698 /Source="Nicolas_upshift_promotors" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" /label="promotor_no_box" upshifts 3230658 /Source="Nicolas_upshifts" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" promotor_no_box 3230826..3230926 /Source="Nicolas_upshift_promotors" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 3230886..3230972 /Source="Nicolas_S_feature" /locus_tag="new_3410379_3410465" /HighExp="T5.0H, T4.0H, T3.30H, Lbstat, T3.0H, nit, T2.0H, T2.30H, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.317" /TUlongSig="Sig-" /TUlongPSig="0.278" /label="S1278" upshifts 3230886 /Source="Nicolas_upshifts" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" CDS 3230973..3232130 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase" /protein_id="NP_391204.1" /db_xref="EnsemblGenomes-Gn:BSU33240" /db_xref="EnsemblGenomes-Tr:CAB15314" /db_xref="GOA:O34714" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="PDB:1J58" /db_xref="PDB:1L3J" /db_xref="PDB:1UW8" /db_xref="PDB:2UY8" /db_xref="PDB:2UY9" /db_xref="PDB:2UYA" /db_xref="PDB:2UYB" /db_xref="PDB:2V09" /db_xref="PDB:3S0M" /db_xref="PDB:4MET" /db_xref="PDB:5HI0" /db_xref="SubtiList:BG14148" /db_xref="UniProtKB/Swiss-Prot:O34714" /translation="MKKQNDIPQPIRGDKGATVKIPRNIERDRQNPDMLVPPETDHGT VSNMKFSFSDTHNRLEKGGYAREVTVRELPISENLASVNMRLKPGAIRELHWHKEAEW AYMIYGSARVTIVDEKGRSFIDDVGEGDLWYFPSGLPHSIQALEEGAEFLLVFDDGSF SENSTFQLTDWLAHTPKEVIAANFGVTKEEISNLPGKEKYIFENQLPGSLKDDIVEGP NGEVPYPFTYRLLEQEPIESEGGKVYIADSTNFKVSKTIASALVTVEPGAMRELHWHP NTHEWQYYISGKARMTVFASDGHARTFNYQAGDVGYVPFAMGHYVENIGDEPLVFLEI FKDDHYADVSLNQWLAMLPETFVQAHLDLGKDFTDVLSKEKHPVVKKKCSK*" gene 3230973..3232130 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" downshifts 3232116 /Source="Nicolas_upshifts" /id="D1717" /incds=0 /nref=11 /ntot=87 /MaxReadThrough="4.83038" /MaxDrop="4.39135" /score="2.61432951" /energy="-9.4" /TU="U2607" /idTUdmin="U2607" /TUdmin="-484" /isTUend="FALSE" CDS 3232191..3232601 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18573182, 19047353, 26651345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18573182, 19047353, 26651345; Product type f: factor" /codon_start=1 /transl_table=11 /product="acid stress-sensitive anti sigma factor" /protein_id="NP_391205.1" /db_xref="EnsemblGenomes-Gn:BSU33250" /db_xref="EnsemblGenomes-Tr:CAB15315" /db_xref="GOA:O34686" /db_xref="InterPro:IPR025912" /db_xref="SubtiList:BG14149" /db_xref="UniProtKB/Swiss-Prot:O34686" /translation="MKHQNPSKRLLRLSIKYLLAAAAVVLTYFAVIYILFSLAGTSYR SAAHVLLFAVVFLVLGLCFEPFERLMIHSFTFFKTGKRLFILLAGIVQLLFLWMTAHT TDQLISDIWLSTTEEMIVAAVFLILDKCNSALPS*" gene 3232191..3232601 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" downshifts 3232600 /Source="Nicolas_upshifts" /id="D1718" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.57216" /MaxDrop="3.72691" /score="-9.50136752" /energy="-7.4" /TU="NA" /idTUdmin="U2607" /TUdmin=0 /isTUend="TRUE" CDS complement(3232635..3233864) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391207.3" /db_xref="EnsemblGenomes-Gn:BSU33260" /db_xref="EnsemblGenomes-Tr:CAB15317" /db_xref="GOA:P46324" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG11368" /db_xref="UniProtKB/Swiss-Prot:P46324" /translation="MLEHIRISFQSIFSHKLRSILTMLGVIIGIAAIIAIVSMLKGQS EQLKQSMIGMGNNAINVVYQPSGGEEESGGPQVSYASAPPVAEETVKAIKSDPMVKGL SLYYLSEGASVFHLTNVSYPQVYGVDDDYFDMFPIRITEGRKLTENDLNSTHQVVMIN EAVRDELFPDGEALHKSIEMNGVPFKVVGVFKEKNQQESMFEGDYANPVLYVPKKVWP LIEGFDAPTQIAVQADSSEHIQEAGVMAADLLNQGLSEAELEKAEYSVMDLQEIAQEV ESFNQSFALLLGGIASISLLVGGIGVMNIMLVSVTERTREIGIKKALGAKRRVILFQF LTEAVVLTSIGGILGVLAGFGIAKLLTVIFPMPFIVSIPAVVGALIFSMAVGIIFGLL PSIKASKLQPVDALRYE*" gene complement(3232635..3233864) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" downshifts complement(3232652) /Source="Nicolas_upshifts" /id="D1719" /incds=0 /nref=10 /ntot=218 /MaxReadThrough="2.36812" /MaxDrop="4.29282" /score="13.74435" /energy="-11.3" /TU="NA" /idTUdmin="U2608" /TUdmin="-20" /isTUend="TRUE" CDS complement(3233857..3234546) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544226, 22517742; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391208.2" /db_xref="EnsemblGenomes-Gn:BSU33270" /db_xref="EnsemblGenomes-Tr:CAB15318" /db_xref="GOA:O34979" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14151" /db_xref="UniProtKB/Swiss-Prot:O34979" /translation="MLTLNNISKSYKLGKEEVPILKHINLTVQAGEFLAIMGPSGSGK STLMNIIGCLDRPTSGTYTLDQIDILKGKDGALAEIRNESIGFVFQTFHLLPRLTALQ NVELPMIYNKVKKKERRQRAYEALEKVGLKDRVSYKPPKLSGGQKQRVAIARALVNQP RFILADEPTGALDTKSSEQILALFSELHREGKTIIMITHDPDVAKKADRTVFIRDGEL VLDERGDISHA*" gene complement(3233857..3234546) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" CDS complement(3234530..3235723) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter membrane fusion component" /protein_id="NP_391209.1" /db_xref="EnsemblGenomes-Gn:BSU33280" /db_xref="EnsemblGenomes-Tr:CAB15319" /db_xref="GOA:O35007" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG14152" /db_xref="UniProtKB/Swiss-Prot:O35007" /translation="MSKKKKWLIGGAICAGVLVLAGIGAGGFYFFTHMNQVAVSSEPY AESVAVYMGGDSESGQTFSGKVEPEKQQKVYIDSEKGSIKKTYVKEGDQVKKGDKLFE YEGEDHSDEVEQANLQIEMTNLQINRLQKSITETEKKLKVAGKEEKNQLQDELDQTNF DLKTSQLELKQHQKELAGLTKNKGSNVITSKHDGIVQSVNQDIADGATGDQAAGPYIQ IVSTGKYLVKSQINELLMDTIKKGSKVRVTLKTGGEGEWKGKVTSIGKLPAGAGEGEE SESFADEEMNPQSSNYPFTILLDSHKGLEVGYHVNIEVMSDNADADTIKLPSDMVIQD DGEPYVWKADENHKAVKQPVEIGETDENDMVEIKSGLTPEDYVIYPDPAVKEGKQVTV NADTE*" gene complement(3234530..3235723) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" promotor_-10 complement(3235767..3235786) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3235780) /Source="Nicolas_upshifts" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" promotor_-35 complement(3235801..3235808) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3235894..3236703) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ATP-binding protein)" /protein_id="NP_391210.1" /db_xref="EnsemblGenomes-Gn:BSU33290" /db_xref="EnsemblGenomes-Tr:CAB15335" /db_xref="GOA:P49938" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11390" /db_xref="UniProtKB/Swiss-Prot:P49938" /translation="MNSLSTEQLGIGYGDRVIVEDLNISIPKGKITTLIGPNGCGKST ILKTMSRIMRSHAGAVYLNGKAIHKMSTKDIAKDMAILPQTPEAPSGLTVHELVSYGR FPHQSGFGRLNDEDRRIIKWALEETGMAEYAERPIEALSGGQRQRVWIAMALAQGTEL LLLDEPTTYLDLAHQLEILQLLDRLNKEQGRTILMVIHDLNHAARFSHYMIALKKGTV IKEGTALEVMTPDILKQVFQIDAEIVTDPRTNKPVCLTYDLIKNEKELVTV*" gene complement(3235894..3236703) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" downshifts complement(3235911) /Source="Nicolas_upshifts" /id="D1720" /incds=0 /nref=190 /ntot=245 /MaxReadThrough="1.31294" /MaxDrop="6.48454" /score="40.5986253" /energy="-11" /TU="NA" /idTUdmin="U2610" /TUdmin="-1" /isTUend="TRUE" promotor_-35 3236050..3236059 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3236072..3236091 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3236076 /Source="Nicolas_upshifts" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3236719..3237729) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251, 15849754, 16850406, 24362930; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391211.1" /db_xref="EnsemblGenomes-Gn:BSU33300" /db_xref="EnsemblGenomes-Tr:CAB15336" /db_xref="GOA:P49937" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11391" /db_xref="UniProtKB/Swiss-Prot:P49937" /translation="MKTKTNKPLIVMAVTFLLIVVVFFISLNLGVIKIAPLKTLQVFF GQGTARDELVLFEFRLPRIILSLLVGAGISVAGAILQSVSQNELAEPGILGINAGGSL AVVLFIYFFQGSASDLSFFGTFMLPFSALAGAILAAFLIYILAWKKGVTPIRLILVGI GVNAGFNALLLIFQLKMDPHDFMQAAVWISGSIWGANWNMIWAILPWIVILLLFTLYK ARYLNIMQLGDQLATGLGTAVEKERRILLLAAVTLAASCVAAAGGIAFLGLIAPHVAR RLTGPRHQTLIPVSAFIGSFLFLLADTLARNVLAPSEIPVGLVISVLGAPYFIYLLMK AN*" gene complement(3236719..3237729) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" CDS complement(3237729..3238883) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 15849754, 16850406, 24362930; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391212.1" /db_xref="EnsemblGenomes-Gn:BSU33310" /db_xref="EnsemblGenomes-Tr:CAB15337" /db_xref="GOA:P49936" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11389" /db_xref="UniProtKB/Swiss-Prot:P49936" /translation="MHFHFCSKHSIKSAEKSDILKQQLIIIISNRKEVRQLSQHKNIR TASEEIQWTSRTYGAVIVLIAGLCLLCLGAFLSISLGAADIHLRTVWEAIFHYQPTKT SHQIIHDLRLPRTAAAALVGALLAVSGAIMQGMTRNPLAEPSIMGVTSGSAFAVSIAF AFFPGLSAMGLVLWSFAGAGLGASTVMGIGMFSRGGLTPVKLALAGTAVTYFFTGIST AIAIRFDVAQDISFWYAGGVAGVKWSGVQLLLIAGAVGLTLAFFIARSVTVLSLGDDL AKGLGQYTSAVKLVGMLIVVILTGAAVSIAGTIAFIGLIIPHITRFLVGVDYRWIIPC SAVLGAVLLVFADIAARLVNAPFETPVGALTSLIGVPFFFYLARRERRGL*" gene complement(3237729..3238883) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" promotor_-10 complement(3238816..3238835) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3238833) /Source="Nicolas_upshifts" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" promotor_-35 complement(3238847..3238854) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3238895..3238902 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3238917..3238936 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3238926 /Source="Nicolas_upshifts" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" CDS 3238981..3239928 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 26919525; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ferrichrome-bindinglipoprotein)" /protein_id="NP_391213.1" /db_xref="EnsemblGenomes-Gn:BSU33320" /db_xref="EnsemblGenomes-Tr:CAB15338" /db_xref="GOA:P37580" /db_xref="InterPro:IPR002491" /db_xref="PDB:3G9Q" /db_xref="PDB:3HXP" /db_xref="SubtiList:BG10828" /db_xref="UniProtKB/Swiss-Prot:P37580" /translation="MTHIYKKLGAAFFALLLIAALAACGNNSESKGSASDSKGAETFT YKAENGNVKIPKHPKRVVVMADGYYGYFKTLGINVVGAPENVFKNPYYKGKTNGVENI GDGTSVEKVIDLNPDLIIVWTTQGADIKKLEKIAPTVAVKYDKLDNIEQLKEFAKMTG TEDKAEKWLAKWDKKVAAAKTKIKKAVGDKTISIMQTNGKDIYVFGKDFGRGGSIIYK DLGLQATKLTKEKAIDQGPGYTSISLEKLPDFAGDYIFAGPWQSGGDDGGVFESSIWK NLNAVKNGHVYKMDPIGFYFTDPISLEGQLEFITESLTK*" gene 3238981..3239928 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" downshifts 3239904 /Source="Nicolas_upshifts" /id="D1721" /incds=0 /nref=168 /ntot=245 /MaxReadThrough="3.82329" /MaxDrop="5.73183" /score="11.0136807" /energy="-12.1" /TU="U2611" /idTUdmin="U2611" /TUdmin="-22" /isTUend="TRUE" downshifts 3239948 /Source="Nicolas_upshifts" /id="D1722" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="3.01143" /MaxDrop="4.08479" /score="11.0136807" /energy="-12.1" /TU="NA" /idTUdmin="U2611" /TUdmin=22 /isTUend="TRUE" downshifts 3240102 /Source="Nicolas_upshifts" /id="D1723" /incds=0 /nref=8 /ntot=87 /MaxReadThrough="0.219110000000001" /MaxDrop="3.67928" /score="7.53231618" /energy="-13.7" /TU="NA" /idTUdmin="U2611" /TUdmin=176 /isTUend="FALSE" CDS complement(3240163..3241572) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14627808, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lysine permease" /protein_id="NP_391214.1" /db_xref="EnsemblGenomes-Gn:BSU33330" /db_xref="EnsemblGenomes-Tr:CAB15339" /db_xref="GOA:O32204" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG14154" /db_xref="UniProtKB/Swiss-Prot:O32204" /translation="MEQTKKWGFWLLTAFVVGNMVGSGIFSLPSSLASIASPFGATSA WLLTGAGVLMIALVFGHLSIRKPELTAGPQSYARALFSDPKKGNAAGFTMVWGYWVAS WISNVAIITSLAGYLTSFFPILVDKREMFSIGGQEVTLGQLLTFAVCTILLWGTHAIL VASINGASKLNFVTTLSKVLGFVFFIVAGLFVFQTSLFGHFYFPVQGENGTSIGIGGQ VHNAAISTLWAFVGIESAVILSGRARSQRDVKRATITGLLIALSIYIIVTLITMGVLP HDKLVGSEKPFVDVLYAIVGNAGSVIMALLAILCLFGTMLGWILLGSEVPYQAAKAGD FPAFFAKTNKKGSPVIALIITNVMSQVFIFSVISRTISDAFTFLTTAATLAYLIPYLV SAIYSLKVVIKGETYDQLKGSRVRDGLIAILACAYSVFVIVTGTADLTTFILGIGLFF VGLIVYPFVSNKFQKEKQA*" gene complement(3240163..3241572) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" downshifts complement(3240178) /Source="Nicolas_upshifts" /id="D1724" /incds=0 /nref=168 /ntot=213 /MaxReadThrough="0.441040000000001" /MaxDrop="6.03347" /score="23.064706" /energy="-13.7" /TU="NA" /idTUdmin="U2613" /TUdmin=0 /isTUend="TRUE" promotor_-35 3240990..3240994 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3241012..3241028 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3241019 /Source="Nicolas_upshifts" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" S_feature 3241026..3241993 /Source="Nicolas_S_feature" /locus_tag="new_3420519_3421486" /HighExp="S3, S4, S7, S5, S8, S6, Etha, M9-stat, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="7.6401427420847101E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.4" /TUlongSig="NA" /TUlongPSig="NA" /label="S1279" downshifts complement(3241674) /Source="Nicolas_upshifts" /id="D1725" /incds=0 /nref=1 /ntot=43 /MaxReadThrough="5.98281" /MaxDrop="3.61093" /score="-2.14086757" /energy="-5" /TU="U2613,U2614" /idTUdmin="U2614" /TUdmin="-110" /isTUend="FALSE" misc_RNA complement(3241676..3241855) /gene="kswB" /locus_tag="BSU_misc_RNA_54" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22416067; Product type n: RNA" gene complement(3241676..3241855) /gene="kswB" /locus_tag="BSU_misc_RNA_54" promotor_-10 complement(3241885..3241902) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3241896) /Source="Nicolas_upshifts" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" promotor_-35 complement(3241917..3241924) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3241950 /Source="Nicolas_upshifts" /id="D1726" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.6441" /MaxDrop="3.53891" /score="-0.527038766" /energy="-4.8" /TU="U2612" /idTUdmin="U2612" /TUdmin="-462" /isTUend="FALSE" CDS complement(3241972..3242112) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054593.1" /db_xref="EnsemblGenomes-Gn:BSU33340" /db_xref="EnsemblGenomes-Tr:CAE01467" /db_xref="GOA:Q7WY58" /db_xref="InterPro:IPR014220" /db_xref="SubtiList:BG14174" /db_xref="UniProtKB/Swiss-Prot:Q7WY58" /translation="MGFFNKDKGKRSEKEKNVIQGALEDAGSALKDDPLQEAVQKKKN NR*" gene complement(3241972..3242112) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" downshifts complement(3241982) /Source="Nicolas_upshifts" /id="D1727" /incds=0 /nref=40 /ntot=87 /MaxReadThrough="4.06523" /MaxDrop="5.5784" /score="-1.94521013" /energy="-14.5" /TU="U2614" /idTUdmin="U2614" /TUdmin="-418" /isTUend="FALSE" upshifts complement(3242140) /Source="Nicolas_upshifts" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" S_feature complement(3242142..3242730) /Source="Nicolas_S_feature" /locus_tag="new_3421635_3422223_c" /HighExp="S6, S8, S7, S5, BT, G135, Diami, G180, LBGstat, S4" /AntisenseName="yvsG" /AntisenseCor="0.46604658967097301" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1280" promotor_-10 complement(3242145..3242156) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-10" promotor_-35 complement(3242170..3242176) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-35" promotor_-35 3242202..3242209 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3242223 /Source="Nicolas_upshifts" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" promotor_-10 3242225..3242244 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3242279..3242761 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_391215.1" /db_xref="EnsemblGenomes-Gn:BSU33350" /db_xref="EnsemblGenomes-Tr:CAB15340" /db_xref="GOA:O32205" /db_xref="InterPro:IPR007404" /db_xref="InterPro:IPR016956" /db_xref="SubtiList:BG14153" /db_xref="UniProtKB/Swiss-Prot:O32205" /translation="MTGKTHIMGGIASCTAAAYYYGFDPVLMAASGAVGALIPDICHT QSKIGRKFPILSKVVSSVFGHRTFTHSLLFMLIMFFITSTYIPDKNISAGLMIGMASH LILDAWTVNGIKLLFPSTIRVRLPLYMKTGSFSEQLVLAGLTLASCYYFYMLFHGRMF *" gene 3242279..3242761 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" promotor_-35 3242775..3242782 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3242796..3242815 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3242808 /Source="Nicolas_upshifts" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" CDS 3242861..3244714 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="primase of polyglycerolphosphate lipoteichoic acid (LTA) synthesis" /protein_id="NP_391216.1" /db_xref="EnsemblGenomes-Gn:BSU33360" /db_xref="EnsemblGenomes-Tr:CAB15341" /db_xref="GOA:O32206" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG14092" /db_xref="UniProtKB/Swiss-Prot:O32206" /translation="MKGTFFHNQRFLCFSILFMWIKTYVIYKLGFDLQIDTLLEELML LVNPLSFILPLFGIGLFLKENKQRAFLLIANLVLTVILISNTIFYGFYIDFITIPVLF QASNMSDMGSSVKELFHPLFIALFVDLVFLLLFARKTKHPQTKAAPHTIKRYYAASCG MLLCTLALAEVQQPKLLAHSFDREMLVKSIGLFQFHIYDTISQTVNISAKAFADEDSI TAIKNYTEADYSKPDQSKFGLAKGRNVIFVTLESTQSFVLNEKVNGKEITPFMNDLIK KSYSFDHFYQQTEQGKTSDSEFIVANSLYPSLSGAVFFTKSDHQFHTMYKSLKQHDYY SAVFHANHKTFWNRDVMYDTFGIDRFFDVDDFHVTPGTSTSWGLKDKEFLEQSAKKLK SLPQPFYSSFITLTNHFPFEIDEKDQLIDEFDSSSDLLNRYVTTVRYEDEALKHFIKK LKDEGLYENSMIVFMGDHYGISEAHNEAMAEFLGKDEITPYDNVQLQRVPFIIHIPGI TDQQPETIPDAGGQVDVRPTLMHLLGVETKGDIQFGNDLLSGDRTPFAVLRNGSFITN DYVYTKNTCYSQKTGEVLEDQDACLPYKEKANEELSLSDKILNGDLLRFSE*" gene 3242861..3244714 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" downshifts 3244700 /Source="Nicolas_upshifts" /id="D1728" /incds=0 /nref=30 /ntot=171 /MaxReadThrough="1.18268" /MaxDrop="3.6959" /score="21.1397957" /energy="-10.5" /TU="NA" /idTUdmin="U2615" /TUdmin=0 /isTUend="TRUE" CDS complement(3244742..3245668) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative molybdate binding regulator" /protein_id="NP_391217.1" /db_xref="EnsemblGenomes-Gn:BSU33370" /db_xref="EnsemblGenomes-Tr:CAB15342" /db_xref="GOA:O32207" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010093" /db_xref="InterPro:IPR024370" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14093" /db_xref="UniProtKB/Swiss-Prot:O32207" /translation="MNETSSYTIEEVAGLLKVSKLTVYDLIKKGVLPAYRVGRQMRVD EEDLKQYKTNMRMSQPIAAKEAPKQVQEAEPDGRPNVMISGQDISMDILSKHLENAIQ ETPLRKYKGSLNSLIDMYQGKCDIVSLHLYDAETGQYNAPYVKRILTGEPFCLINVVL RKAGLYVQKGNPKNIQGWKDLKRADIRIINREKGSGARVLLDEQLGLLGVNPADVVGY GDIVTDHYAAASQVSSGQADAGIGAQHAAHMGSVDFIPLIDEQYDIVVLKKNEQLLKA VKEILNSEDYKANLSHLNGYETKLTGKVILET*" gene complement(3244742..3245668) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" downshifts complement(3244754) /Source="Nicolas_upshifts" /id="D1729" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="0.15268" /MaxDrop="6.72558" /score="21.9965704" /energy="-10.5" /TU="NA" /idTUdmin="U2617" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3245680..3245699) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3245701) /Source="Nicolas_upshifts" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" promotor_-35 complement(3245715..3245718) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3245737..3245756 /Source="Nicolas_upshift_promotors" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3245746 /Source="Nicolas_upshifts" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" CDS 3245779..3246561 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9302996; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molybdate-binding lipoprotein" /protein_id="NP_391218.1" /db_xref="EnsemblGenomes-Gn:BSU33380" /db_xref="EnsemblGenomes-Tr:CAB15343" /db_xref="GOA:O32208" /db_xref="InterPro:IPR005950" /db_xref="SubtiList:BG14094" /db_xref="UniProtKB/Swiss-Prot:O32208" /translation="MFKKYSIFIAALTAFLLVAGCSSNQSSTDSEKKVTLTISAAASA QDALEEIQKNYEKDHQHITIQDNYGSSGALQKQISQGAGADLFFSAAEDKFKKLVDDG DIAKKDSTELVGNEIVLVVPKNGDSPVTSFSNLAESEKIALGTPESVPAGAYGKESLT KLSLWDKVKDKIVYGKDVRQVLSYVETGNVDAGVVYKTDALVSKKVNIVDEAKADTHS PIVYPLGIVKDTKHRKEAKEFYEYLQSDEAMKVFEKYGFTAE*" gene 3245779..3246561 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" CDS 3246533..3247225 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="molybdenum transport permease" /protein_id="NP_391219.3" /db_xref="EnsemblGenomes-Gn:BSU33390" /db_xref="EnsemblGenomes-Tr:CAB15344" /db_xref="GOA:O32209" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011867" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14095" /db_xref="UniProtKB/Swiss-Prot:O32209" /translation="MRNMALLPSSISASEFFTPVVLSFQVAAVAGIVVIILGTLAGAW MSRASFFGKTALETCFMLPLVLPPTVVGFILIVIFGKHSFIGQAIEWIFQQPVIFTWW AAVIASAVVAFPLMYQSAKTGFADIDPDIQGAAMVDGASRWKVFIHISVPLAYPSLLT GSILSLARALGEFGATLMFAGNIPGVTQTLPTAIYVALDSGNNTLAWAWVVCIVVISF LMLFFIQQKKTH*" gene 3246533..3247225 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" downshifts 3247217 /Source="Nicolas_upshifts" /id="D1730" /incds=0 /nref=40 /ntot=195 /MaxReadThrough="0.43895" /MaxDrop="4.92503" /score="19.0609965" /energy="-9.4" /TU="NA" /idTUdmin="U2618" /TUdmin=9 /isTUend="TRUE" CDS complement(3247256..3248086) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" /EC_number="1.1.1.283" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544192, 16232966, 17114254, 19585557" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544192, 16232966, 17114254, 19585557; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous glyoxal/methylglyoxal reductase" /protein_id="NP_391220.1" /db_xref="EnsemblGenomes-Gn:BSU33400" /db_xref="EnsemblGenomes-Tr:CAB15345" /db_xref="GOA:O32210" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3D3F" /db_xref="PDB:3F7J" /db_xref="SubtiList:BG14096" /db_xref="UniProtKB/Swiss-Prot:O32210" /translation="MPTSLKDTVKLHNGVEMPWFGLGVFKVENGNEATESVKAAIKNG YRSIDTAAIYKNEEGVGIGIKESGVAREELFITSKVWNEDQGYETTLAAFEKSLERLQ LDYLDLYLIHWPGKDKYKDTWRALEKLYKDGKIRAIGVSNFQVHHLEELLKDAEIKPM VNQVEFHPRLTQKELRDYCKGQGIQLEAWSPLMQGQLLDNEVLTQIAEKHNKSVAQVI LRWDLQHGVVTIPKSIKEHRIIENADIFDFELSQEDMDKIDALNKDERVGPNPDELLF *" gene complement(3247256..3248086) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" downshifts complement(3247262) /Source="Nicolas_upshifts" /id="D1731" /incds=0 /nref=190 /ntot=269 /MaxReadThrough="4.7445" /MaxDrop="7.9269" /score="27.8070829" /energy="-9.7" /TU="U2620" /idTUdmin="U2620" /TUdmin="-528" /isTUend="FALSE" promotor_-35 3247949..3247953 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3247969..3247973 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3247978 /Source="Nicolas_upshifts" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 3248088 /Source="Nicolas_upshifts" /id="D1732" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="0.95687" /MaxDrop="4.12116" /score="31.5807071" /energy="-11.6" /TU="NA" /idTUdmin="U2618" /TUdmin=880 /isTUend="FALSE" promotor_-10 complement(3248116..3248135) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3248134) /Source="Nicolas_upshifts" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" promotor_-35 complement(3248150..3248157) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3248242..3248248 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3248262 /Source="Nicolas_upshifts" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" promotor_-10 3248263..3248281 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3248309..3248794 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 22307285, 25217289; Product type f: factor" /codon_start=1 /transl_table=11 /product="exported stress induced factor" /protein_id="NP_391221.1" /db_xref="EnsemblGenomes-Gn:BSU33410" /db_xref="EnsemblGenomes-Tr:CAB15346" /db_xref="SubtiList:BG14097" /db_xref="UniProtKB/Swiss-Prot:O32211" /translation="MKRIRIPMTLALGAALTIAPLSFASAEENPAPKMSQTTTAGTTA ADVGLNVNLDVLGIANQIADAIKSAQNRDGFVKNLMESSFYASGQKYNVMVFNLSQEY EDHLNGVQFYGSAVYDGITYGIWVFEDGTFTNKGDGGWINWAFRGWFDRDGSTVAFHR P*" gene 3248309..3248794 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" downshifts 3248793 /Source="Nicolas_upshifts" /id="D1733" /incds=0 /nref=18 /ntot=93 /MaxReadThrough="3.44281" /MaxDrop="6.83046" /score="31.5807071" /energy="-11.6" /TU="U2621" /idTUdmin="U2621" /TUdmin="-571" /isTUend="FALSE" CDS complement(3248838..3250850) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16021482, 16850406, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16021482, 16850406, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_391222.1" /db_xref="EnsemblGenomes-Gn:BSU33420" /db_xref="EnsemblGenomes-Tr:CAB15347" /db_xref="GOA:O32212" /db_xref="InterPro:IPR004705" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR018422" /db_xref="SubtiList:BG14098" /db_xref="UniProtKB/Swiss-Prot:O32212" /translation="MDIFLVVLVLLTIIAISNIVNRFIPFIPVPLIQVALGILAASFP QGLHFELNTELFFVLFIAPLLFNDGKRTPRAELWNLRAPILLLALGLVFATVIVGGYT IHWMIPAIPLAAAFGLAAILSPTDVVAVSALSGRVKMPKGILRLLEGEGLMNDASGLV AFKFAIAAAVTGAFSLAQAAVSFVFISLGGLLCGVVISFLIIRFRLFLRRLGMQDVTM HMLIQILTPFVIYLAAEEIGVSGILAVVAGGITHAVEQDRLESTMIKLQIVSSSTWNI ILFILNGLVFVILGTQIPDVISVIFNDTAISNMKVIGYILVITFTLMLLRFLWVLFFW NGKWFFNKDQNIYKPGLRSTLLISISGVRGAVTLAGSFSIPYFLEDGTPFPERNLILF LAAGVILCTLVIATVVLPILTEKEEEDEERNKKLLTARRKLIKTALQTIKEDMNETNK TASLAVIAEYNEKMKNLRFQQYTSSNRIKKHERKVRAQGVKAEQEALMKMLERGDIPE ETANVLQERFNELEILYANPFKVGLSKTRLKRLMYWIFFGEHKKPEMSILNEAGLIRA TRVKTAKAAIEYLEKHKTDEHKEVFLSVITFYKQLIFRLEHSHHELKSSAHFENQKLE VKLKAVQAIRNEIQTLFEEREISRDISHELRQYINDVEAAMLEGGE*" gene complement(3248838..3250850) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" downshifts complement(3248846) /Source="Nicolas_upshifts" /id="D1734" /incds=0 /nref=118 /ntot=238 /MaxReadThrough="2.66359" /MaxDrop="5.82216" /score="41.6492295" /energy="-13.2" /TU="NA" /idTUdmin="U2622" /TUdmin=0 /isTUend="TRUE" misc_feature complement(3250516..3250520) /Source="Nicolas_upshift_promotors" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3250518) /Source="Nicolas_upshifts" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(3250851..3251002) /Source="Nicolas_S_feature" /locus_tag="new_3430344_3430495_c" /HighExp="dia5, T0.30H, T-0.40H, Salt, Diami, T1.0H, T0.0H, T1.30H, dia15, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.746, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1281" misc_feature complement(3250979..3250997) /Source="Nicolas_upshift_promotors" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3251002) /Source="Nicolas_upshifts" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" CDS complement(3251105..3252820) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (hemoprotein beta-subunit)" /protein_id="NP_391223.1" /db_xref="EnsemblGenomes-Gn:BSU33430" /db_xref="EnsemblGenomes-Tr:CAB15348" /db_xref="GOA:O32213" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR011786" /db_xref="InterPro:IPR036136" /db_xref="SubtiList:BG14099" /db_xref="UniProtKB/Swiss-Prot:O32213" /translation="MVTKILKAPDGSPSDVERIKKESDYLRGTLKEVMLDRISAGIPD DDNRLMKHHGSYLQDDRDLRNERQKQKLEPAYQFMLRVRMPGGVSTPEQWLVMDDLSQ KYGNGTLKLTTRETFQMHGILKWNMKKTIQTIHSALLDTIAACGDVNRNVMCASNPYQ SEIHSEVYEWSKKLSDDLLPRTRAYHEIWLDEERVAGTPEEEVEPMYGPLYLPRKFKI GIAVPPSNDIDVFSQDLGFIAIVEDGKLIGFNVAIGGGMGMTHGDTATYPQLAKVIGF CRPEQMYDVAEKTITIQRDYGNRSVRKNARFKYTVDRLGLENVKEELENRLGWSLEEA KPYHFDHNGDRYGWVEGIEDKWHFTLFVEGGRITDYDDYKLMTGLREIAKVHTGEFRL TANQNLMIANVSSDKKEEISALIEQYGLTDGKHYSALRRSSMACVALPTCGLAMAEAE RYLPTLLDKIEEIIDENGLRDQEITIRMTGCPNGCARHALGEIGFIGKAPGKYNMYLG AAFDGSRLSKMYRENIGEADILSELRILLSRYAKEREEGEHFGDFVIRAGIIKATTDG TNFHD*" gene complement(3251105..3252820) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" downshifts complement(3251112) /Source="Nicolas_upshifts" /id="D1735" /incds=0 /nref=211 /ntot=254 /MaxReadThrough="3.28258" /MaxDrop="6.31358" /score="23.5256972" /energy="-13.8" /TU="U2624" /idTUdmin="U2624" /TUdmin="-572" /isTUend="FALSE" CDS complement(3252846..3254663) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (flavoprotein alpha-subunit)" /protein_id="NP_391224.1" /db_xref="EnsemblGenomes-Gn:BSU33440" /db_xref="EnsemblGenomes-Tr:CAB15349" /db_xref="GOA:O32214" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010199" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14100" /db_xref="UniProtKB/Swiss-Prot:O32214" /translation="MQLQVMNSPFNQEQAELLNRLLPTLTESQKIWLSGYLSAQSVSA QEAAGTPAAAVSAEAPAPAVSKEVTVLYGSQTGNAQGLAENAGKQLEQSGFQVTVSSM SDFKPNQLKKVTNLLIVVSTHGEGEPPDNALSFHEFLHGRRAPKLEDLRFSVLALGDS SYEFFCQTGKEFDQRLEELGGKRISPRVDCDLDYDEPAAEWLEGVLKGLNEAGGGSAA PAPAAASQTGESSYSRTNPFRAEVLENLNLNGRGSNKETRHVELSLEGSGLTYEPGDS LGVYPENDPELVELLLKEMNWDPEEIVTLNKQGDVRPLKEALISHYEITVLTKPLLEQ AAQLTGNDELRELLAPGNEENVKAYIEGRDLLDLVRDYGPFSVSAQEFVSILRKMPAR LYSIASSLSANPDEVHLTIGAVRYDAHGRERKGVCSILCAERLQPGDTLPVYVQHNQN FKLPKDPETPIIMVGPGTGVAPFRSFMQEREETGAEGKAWMFFGDQHFVTDFLYQTEW QNWLKDGVLTKMDVAFSRDTEEKVYVQHRMLEHSAELFEWLQEGAAVYICGDEKHMAH DVHNTLLEIIEKEGNMSREEAEAYLADMQQQKRYQRDVY*" gene complement(3252846..3254663) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" promotor_-10 complement(3254705..3254724) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3254714..3254721 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3254724) /Source="Nicolas_upshifts" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" upshifts 3254727 /Source="Nicolas_upshifts" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 3254734..3254753 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3254737..3254744) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3254834..3257158) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544244, 24520113" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544244, 24520113; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription factor" /protein_id="NP_391225.1" /db_xref="EnsemblGenomes-Gn:BSU33450" /db_xref="EnsemblGenomes-Tr:CAB15350" /db_xref="GOA:O32215" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="SubtiList:BG14101" /db_xref="UniProtKB/Swiss-Prot:O32215" /translation="MNQQDKEWKEEQSRIDEVLKELEKKERFLETSAGGLKHDIIGLR KSFWEDVKVNFDDAHEAIETMASIKQQAELLSDREHNHRRMDQQLKRIHQLKKSPYFG RIDFIENGEEQAERIYIGLASCLDEKEEHFLIYDWRAPISSLYYNYSPGKAEYEVPGE TIEGEMVLKRQFMIKNGTLKAMFNTDMTIGDEMLQEVLSHHSDTQMKNIVSTIQKEQN QIIRNEKSKILIVQGAAGSGKTSAALQRVAYLLYRHRGVIDAGQIVLFSPNFLFNSYV SSVLPELGEENMEQATFQEYIEHRLGRKFKCESPFDQLEYCLTETKGGDFPTRLAGIT WKAGLSFQQFINEYVTRLSSEGMIFKNIIFRGQKLITKEQIQSYFYSLDQNHSIPNRM EQTAKWLLSELNKLEKKERRKDWVVHEAELLDKEDYLDVYKKLQERKRFSESTFNDYQ REQQLLAAIIVKKAFKPLKQAVRLLAFLDVTQLYLQLFSGWGGKFQHEKMDAIGELTR SAFTDNKLLYEDAAPFLYMQDLIEGRKKNTKIKHLFIDEAQDYSPFQMAYMRSIFPAA SMTVLGDINQSIYAHTINGDQRMDACFEDEPAEYVRLKRTYRSTRQIVEFTKAMLQDG ADIEPFNRSGEMPLVVKTEGHESLCQKLAQEIGRLKKKGHETIAVICKTAHQCIQAHA HMSEYTDVRLIHKENQPFQKGVCVIPVYLAKGIEFDAVLVYDASEEHYHTEHDRRLLY TACTRAMHMLAVFYTGEASPFVTAVPPHLYQIAE*" gene complement(3254834..3257158) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" downshifts complement(3254852) /Source="Nicolas_upshifts" /id="D1736" /incds=0 /nref=26 /ntot=168 /MaxReadThrough="1.20405" /MaxDrop="4.59044" /score="18.6044234" /energy="-8.5" /TU="NA" /idTUdmin="U2628" /TUdmin=0 /isTUend="TRUE" promotor_-35 3257178..3257185 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3257200..3257219 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(3257201..3257216) /Source="Nicolas_upshift_promotors" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3257204 /Source="Nicolas_upshifts" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(3257206) /Source="Nicolas_upshifts" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" promotor_-10 complement(3257251..3257270) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3257260) /Source="Nicolas_upshifts" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" promotor_-35 complement(3257286..3257292) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3257296..3257315) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3257316) /Source="Nicolas_upshifts" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" promotor_-35 complement(3257329..3257337) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3257343) /Source="Nicolas_upshifts" /id="D1737" /incds=0 /nref=19 /ntot=158 /MaxReadThrough="2.30604" /MaxDrop="4.26839" /score="16.6103553" /energy="-9.2" /TU="NA" /idTUdmin="U2630" /TUdmin=17 /isTUend="TRUE" CDS complement(3257356..3257964) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391226.1" /db_xref="EnsemblGenomes-Gn:BSU33460" /db_xref="EnsemblGenomes-Tr:CAB15351" /db_xref="GOA:O32216" /db_xref="InterPro:IPR005115" /db_xref="SubtiList:BG14102" /db_xref="UniProtKB/Swiss-Prot:O32216" /translation="MAWELLSVIGIIAFAVSGAIVAMEEEYDILGVYILGIVTAFGGG AIRNLLIGVPVSALWEQGAYFQIALLSITIVFLFPKLLLKHWNKWGNLSDAIGLAAFA IQGALYAVKMGHPLSAVIVAAVLTGSGGGIIRDLLAGRKPLVLKAEIYAVWAALGGLI VGLGWLGNSFGLYVLFFVLVVCRVCSYMFNWKLPNRSFRLDN*" gene complement(3257356..3257964) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" promotor_-10 complement(3258003..3258022) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3258020) /Source="Nicolas_upshifts" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" promotor_-35 complement(3258038..3258042) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3258151..3258567) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391227.1" /db_xref="EnsemblGenomes-Gn:BSU33470" /db_xref="EnsemblGenomes-Tr:CAB15352" /db_xref="GOA:O32217" /db_xref="InterPro:IPR003752" /db_xref="InterPro:IPR012187" /db_xref="InterPro:IPR023380" /db_xref="SubtiList:BG14103" /db_xref="UniProtKB/Swiss-Prot:O32217" /translation="MKNRIVFLYASWVVALIAMLGSLYFSEIRKFIPCELCWYQRILM YPLVLILGIATFQGDTRVKKYVLPMAIIGAFISIMHYLEQKVPGFSGIKPCVSGVPCS GQYINWFGFITIPFLALIAFILIIIFMCLLKGEKSE*" gene complement(3258151..3258567) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" downshifts complement(3258161) /Source="Nicolas_upshifts" /id="D1738" /incds=0 /nref=120 /ntot=264 /MaxReadThrough="1.31968" /MaxDrop="6.21723" /score="26.5991603" /energy="-12.7" /TU="NA" /idTUdmin="U2631" /TUdmin="-9" /isTUend="TRUE" CDS complement(3258572..3259240) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11744713, 11872755, 12637552, 15661011, 17501922, 19535335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11744713, 11872755, 12637552, 15661011, 17501922, 19535335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391228.1" /db_xref="EnsemblGenomes-Gn:BSU33480" /db_xref="EnsemblGenomes-Tr:CAB15353" /db_xref="GOA:O32218" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:3EU3" /db_xref="PDB:3EU4" /db_xref="PDB:3GH9" /db_xref="PDB:3GHA" /db_xref="SubtiList:BG14104" /db_xref="UniProtKB/Swiss-Prot:O32218" /translation="MKKKQQSSAKFAVILTVVVVVLLAAIVIINNKTEQGNDAVSGQP SIKGQPVLGKDDAPVTVVEFGDYKCPSCKVFNSDIFPKIQKDFIDKGDVKFSFVNVMF HGKGSRLAALASEEVWKEDPDSFWDFHEKLFEKQPDTEQEWVTPGLLGDLAKSTTKIK PETLKENLDKETFASQVEKDSDLNQKMNIQATPTIYVNDKVIKNFADYDEIKETIEKE LKGK*" gene complement(3258572..3259240) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" promotor_-10 complement(3259292..3259311) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3259307) /Source="Nicolas_upshifts" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" downshifts complement(3259318) /Source="Nicolas_upshifts" /id="D1739" /incds=0 /nref=3 /ntot=9 /MaxReadThrough="7.34296" /MaxDrop="3.6233" /score="12.4442247" /energy="-11.3" /TU="U2632" /idTUdmin="U2633" /TUdmin=0 /isTUend="TRUE" promotor_-35 complement(3259325..3259330) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3259360..3261468) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" /EC_number="3.6.3.3" /EC_number="3.6.3.5" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Cd(II), Zn(II) and Co(II) exporter (ATPase)" /protein_id="NP_391229.3" /db_xref="EnsemblGenomes-Gn:BSU33490" /db_xref="EnsemblGenomes-Tr:CAB15354" /db_xref="GOA:O32219" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14105" /db_xref="UniProtKB/Swiss-Prot:O32219" /translation="MRLVKQEYVLDGLDCSNCARKIENGVKGIKGINGCAVNFAASTL TVSADGKEEQWVTNKVEKKVKSIDPHVTVRQKHIKKSADDGYRNRMVNMLIRMAAAVI LGAAAYLVQSGTIEFFLFLGAYLIIGGDIIIRAVKNIIRGQVFDEHFLMALATIGAFL IQQYPEGVAVMLFYQIGELFQGAAVSRSRKSISALMDIRPDYANLKTKNGIEQVSSED VQTGDIIVVNPGESIPLDGKVVQGSAMVDTSALTGESVPRKAAEGQDVMSGFINQNGV LHIEVTKGYQESAVSKILDLVQNASSRKARTENFITKFAKYYTPAVVIIAVLLAFVPP LVLSGAALSDWVYRALIFLVISCPCALVVSIPLGFFGGIGAASKAGVLVKGSNYLEAL NQVKYAVFDKTGTLTKGSFEVTEIKPAEGFTKDRLLEAAAYAELHSQHPIAESVRKAY GKMLSSDEIESYEEISGHGIFAKVNGTEILAGNKKLMEREQIEDVPDENAGTIVHVAV DQRYAGAIIIADEIKEDAAQAVADLKSLGIKQTAMLTGDSKQTGEAVGKQLGIGEVYA ELLPQDKVAQVEALEAKLLPSEKLIFVGDGINDTPVLARADIGVAMGGLGSDAAVEAA DIVLMTDQPSKIAEAIRIAKRTRRIVWQNIGFALGVKAIFLILGAFGIATMWEAVFSD VGVTLLAVANAMRVMRLKNK*" gene complement(3259360..3261468) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" S_feature complement(3261460..3261561) /Source="Nicolas_S_feature" /locus_tag="new_3440953_3441054_c" /HighExp="dia5, LBGtran, LBGstat, Diami, LBGexp, Gly, Lbtran, T0.30H, M40t45, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.982, 0.999" /TUlongSig="SigB" /TUlongPSig="0.587" /label="S1282" promotor_-10 complement(3261555..3261574) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3261561) /Source="Nicolas_upshifts" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" promotor_-35 complement(3261590..3261597) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3261628..3264036) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" /EC_number="3.6.3.54" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper transporter ATPase" /protein_id="NP_391230.2" /db_xref="EnsemblGenomes-Gn:BSU33500" /db_xref="EnsemblGenomes-Tr:CAB15355" /db_xref="GOA:O32220" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="PDB:1JWW" /db_xref="PDB:1KQK" /db_xref="PDB:1OPZ" /db_xref="PDB:1OQ3" /db_xref="PDB:1OQ6" /db_xref="PDB:1P6T" /db_xref="PDB:2RML" /db_xref="PDB:2VOY" /db_xref="SubtiList:BG14106" /db_xref="UniProtKB/Swiss-Prot:O32220" /translation="MSEQKEIAMQVSGMTCAACAARIEKGLKRMPGVTDANVNLATET SNVIYDPAETGTAAIQEKIEKLGYHVVTEKAEFDIEGMTCAACANRIEKRLNKIEGVA NAPVNFALETVTVEYNPKEASVSDLKEAVDKLGYKLKLKGEQDSEAAAKKKEERKQTA RLIFSAVLSFPLLWAMVSHFTFTSFIWVPDIFLNPWMQFALATPVQFLIGWPFYVGAY KALRNKSANMDVLVALGTTAAYAYSLYLTFQSIGSHGHTDGLYYETSAILLTLILLGK LFETKAKGRSSDAIKKLMKLQAKTATVVRDGQEQIIPIDEVLVNDIVYVKPGERIPVD GEVVEGRSAVDESMITGESLPVDKNPGDSVTGSTVNANGFLKIKAVNVGKDTALSHII KIVEEAQGSKAPIQRLADQISGIFVPIVLGIAVLTFLIWYLWAAPGDFAEAISKFIAV LVIACPCALGLATPTSIMAGSGRAAEFGILFKGGEHLEKTHRLDTIVLDKTGTVTNGK PRLTDAIPFGRFEEKDLLQFAAAAETGSEHPLGEAIIAGVKDKGLEIPKLTRFEAKVG AGILAEAGGKSILVGTRKLMESEQVEHGALLAQMEELEAEGKTVMLVSIDGEAAGLVA VADTIKDTSRKAVARLKELGLDVIMMTGDNRRTAEAIAKEAGIANIIAEVLPEQKAAE IARLQKEGRQTAMVGDGINDAPALATADIGMAIGTGTDIAMETADITLIRGDLNSIAD AIRMSRLTMKNIKQNLFWALGYNSLGIPIAALGFLAPWIAGAAMAFSSVSVVLNALRL QKVK*" gene complement(3261628..3264036) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" downshifts complement(3261650) /Source="Nicolas_upshifts" /id="D1740" /incds=0 /nref=15 /ntot=68 /MaxReadThrough="5.02116" /MaxDrop="3.63756" /score="26.9828242" /energy="-7.9" /TU="U2633" /idTUdmin="U2635" /TUdmin=0 /isTUend="TRUE" downshifts complement(3261716) /Source="Nicolas_upshifts" /id="D1741" /incds=1 /nref=52 /ntot=227 /MaxReadThrough="5.93949" /MaxDrop="4.28993" /score="26.9828242" /energy="-7.9" /TU="U2633,U2635" /idTUdmin="U2635" /TUdmin="-66" /isTUend="FALSE" S_feature complement(3264037..3264119) /Source="Nicolas_S_feature" /locus_tag="new_3443530_3443612_c" /HighExp="Diami, dia5, dia15, Gly, T0.30H, Heat, T1.0H, T1.30H, T0.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.999, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S1283" CDS complement(3264120..3264329) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344; Product type f: factor" /codon_start=1 /transl_table=11 /product="copper insertion chaperone and transporter component" /protein_id="NP_391231.1" /db_xref="EnsemblGenomes-Gn:BSU33510" /db_xref="EnsemblGenomes-Tr:CAB15356" /db_xref="GOA:O32221" /db_xref="InterPro:IPR000428" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR036163" /db_xref="PDB:1K0V" /db_xref="PDB:1P8G" /db_xref="PDB:2QIF" /db_xref="PDB:3I9Z" /db_xref="SubtiList:BG14107" /db_xref="UniProtKB/Swiss-Prot:O32221" /translation="MEQKTLQVEGMSCQHCVKAVETSVGELDGVSAVHVNLEAGKVDV SFDADKVSVKDIADAIEDQGYDVAK*" gene complement(3264120..3264329) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" promotor_-10 complement(3264353..3264372) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-10" upshifts complement(3264374) /Source="Nicolas_upshifts" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" promotor_-35 complement(3264385..3264391) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-35" CDS complement(3264403..3264708) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17143269, 18048925, 22904286, 24831014, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17143269, 18048925, 22904286, 24831014, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of copper utilisation proteins-Cu(I)" /protein_id="NP_391232.1" /db_xref="EnsemblGenomes-Gn:BSU33520" /db_xref="EnsemblGenomes-Tr:CAB15357" /db_xref="GOA:O32222" /db_xref="InterPro:IPR003735" /db_xref="SubtiList:BG14108" /db_xref="UniProtKB/Swiss-Prot:O32222" /translation="MEKHNEHKTLNHKSSKEKDQITNRLKRIEGQVRGIQNMVENDRY CVDILVQISAVQAAMKNVALHLLEDHAHHCVADAIKSGDGEQAISELLDVFKKFTKS* " gene complement(3264403..3264708) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" misc_feature 3264672..3264691 /Source="Nicolas_upshift_promotors" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3264683 /Source="Nicolas_upshifts" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3264722..3264741) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-10" upshifts complement(3264748) /Source="Nicolas_upshifts" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" promotor_-35 complement(3264755..3264761) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-35" promotor_-35 3264800..3264806 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3264821..3264839 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3264829 /Source="Nicolas_upshifts" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" CDS 3264836..3265912 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" /EC_number="1.1.1.371" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15937154, 20133360, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 20133360, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NADP(+)-dependent)" /protein_id="NP_391233.1" /db_xref="EnsemblGenomes-Gn:BSU33530" /db_xref="EnsemblGenomes-Tr:CAB15358" /db_xref="GOA:O32223" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="PDB:3GDO" /db_xref="PDB:3GFG" /db_xref="SubtiList:BG14057" /db_xref="UniProtKB/Swiss-Prot:O32223" /translation="MITLLKGRRKVDTIKVGILGYGLSGSVFHGPLLDVLDEYQISKI MTSRTEEVKRDFPDAEVVHELEEITNDPAIELVIVTTPSGLHYEHTMACIQAGKHVVM EKPMTATAEEGETLKRAADEKGVLLSVYHNRRWDNDFLTIKKLISEGSLEDINTYQVS YNRYRPEVQARWREKEGTATGTLYDLGSHIIDQTLHLFGMPKAVTANVMAQRENAETV DYFHLTLDYGKLQAILYGGSIVPANGPRYQIHGKDSSFIKYGIDGQEDALRAGRKPED DSWGADVPEFYGKLTTIRGSDKKTETIPSVNGSYLTYYRKIAESIREGAALPVTAEEG INVIRIIEAAMESSKEKRTIMLEH*" gene 3264836..3265912 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" downshifts 3265899 /Source="Nicolas_upshifts" /id="D1742" /incds=0 /nref=155 /ntot=248 /MaxReadThrough="2.17322" /MaxDrop="6.48885" /score="-5.36701412" /energy="-19.4" /TU="NA" /idTUdmin="U2636" /TUdmin="-9" /isTUend="TRUE" CDS complement(3265949..3266584) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17284825, 17725564, 18208493" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17284825, 17725564, 18208493; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:dichloroindophenol oxidoreductase (2-methylhydroquinone resistance)" /protein_id="NP_391234.1" /db_xref="EnsemblGenomes-Gn:BSU33540" /db_xref="EnsemblGenomes-Tr:CAB15359" /db_xref="GOA:O32224" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14058" /db_xref="UniProtKB/Swiss-Prot:O32224" /translation="MAKVLYITAHPHDEATSYSMATGKAFIESYKEANPNDEVVHIDL YKENIPHIDADVFSGWGKLQSGTGFEELSESEKAKVGRLGELSDQFASADKYVFVTPL WNFSFPPVMKAYLDSVAVAGKSFKYTEQGPVGLLTDKKAIHIQARGGYYSEGPAAEME MGHRYIGIMMNFFGVPSFDGIFVEGHNAEPDKAQQIKEDAIARAKEAGKTF*" gene complement(3265949..3266584) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" downshifts complement(3265962) /Source="Nicolas_upshifts" /id="D1743" /incds=0 /nref=211 /ntot=263 /MaxReadThrough="1.58189" /MaxDrop="6.89477" /score="31.0885268" /energy="-15.4" /TU="NA" /idTUdmin="U2637" /TUdmin=0 /isTUend="TRUE" S_feature complement(3266585..3266682) /Source="Nicolas_S_feature" /locus_tag="new_3446078_3446175_c" /HighExp="Heat, UNK1, G/S, Salt, HiTm, GM-0.1, MG 25, SMM, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1284" promotor_-10 complement(3266662..3266681) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3266682) /Source="Nicolas_upshifts" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" promotor_-35 complement(3266695..3266701) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3266744..3268639) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12107147, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391235.1" /db_xref="EnsemblGenomes-Gn:BSU33550" /db_xref="EnsemblGenomes-Tr:CAB15360" /db_xref="GOA:O32225" /db_xref="SubtiList:BG14059" /db_xref="UniProtKB/Swiss-Prot:O32225" /translation="MNKTAANNQRIMPIVKDAFRIHANPFPWKKAIGSGFASGFPVLV GALAGHTDYGLIASIGGFVYLYAGGESYKKRALKLLLVSIGIALSFGLGTLLSGMLWM MAAVLGLIGAAAMFIFSALGIQGPAPMFFVLAFLVSSGLPADPSQALFRAGLTFLGGI FAMGIALIGWLWNKHGPEGAVLQKTYHQLAACLSAVGTPGFHNAQHQTVLMLRTARQT VLGKGNRRKKSRHDERFFRLLEKADDIFIAIIHFSAETPDRETAQIEKALRQTGDMLA NARVFNTFQINENESEPRRKLFEEINEVLYIASGRFDKQLDGEPSRLPSSFYFLRNAF DWKSPVLIRALKYGIVLFAADMFALAFGFARSYWIPLSAAAVMLGTTVVFTLHRAIQR SAGTVIGVILAGAILFFKPGGVYIAFCIAALQCLLEMLIVRNYALAVPFLTANALVIT ESMHGGAGAGYFMIARLTDVAVGSVIGLLGTMLLWRRFSTKRLPELVRNVIRLEGQFM EKLLTGQIADEHKLRVSLVRLRDAYDKALGEFPHANADALWPAISGAQHLGYYLLSAQ AHRRPSAPFSDEEINQLRAFFEQAEQSFIMKRMPADIQVPHVPHYPRISKELSALYSG LRTAFEK*" gene complement(3266744..3268639) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" promotor_-10 complement(3268690..3268701) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3268690) /Source="Nicolas_upshifts" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3268716..3268722) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3268789) /Source="Nicolas_upshifts" /id="D1744" /incds=0 /nref=20 /ntot=155 /MaxReadThrough="2.49984" /MaxDrop="4.21522" /score="11.4033831" /energy="-8" /TU="NA" /idTUdmin="U2639" /TUdmin="-11" /isTUend="TRUE" CDS complement(3268802..3269203) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391236.1" /db_xref="EnsemblGenomes-Gn:BSU33560" /db_xref="EnsemblGenomes-Tr:CAB15361" /db_xref="GOA:O32226" /db_xref="InterPro:IPR020348" /db_xref="SubtiList:BG14060" /db_xref="UniProtKB/Swiss-Prot:O32226" /translation="MRYMKLFFLVTDIGFILYWLSAGFSLIPESWAFKHHDHPFMIAW NWSFFPLDILISVTGLYSLYLQRVNRADWKLMALISLVLTCCSGLQALSFWTFSSDFD LVWWLFNGYLLIYPLFFIHLLLKEGRRTKQS*" gene complement(3268802..3269203) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" CDS complement(3269200..3269559) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11948170, 15849754, 16850406, 19549332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite-efflux transporter" /protein_id="NP_391237.1" /db_xref="EnsemblGenomes-Gn:BSU33570" /db_xref="EnsemblGenomes-Tr:CAB15362" /db_xref="GOA:O32227" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG14061" /db_xref="UniProtKB/Swiss-Prot:O32227" /translation="MNWVFLCLAILFEVAGTVSMKLSSGFTKLIPSLLLIFFYGGSLF FLTLTLKSIDVSVAYAVWSGMGIVLITVVGFLFFQEHVSVMKVISIGLIIAGVVSLNL IEHVAVSEPVHKSGQYK*" gene complement(3269200..3269559) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" CDS complement(3269556..3270128) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391238.1" /db_xref="EnsemblGenomes-Gn:BSU33580" /db_xref="EnsemblGenomes-Tr:CAB15363" /db_xref="GOA:O32228" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG14062" /db_xref="UniProtKB/Swiss-Prot:O32228" /translation="MDKRILAETFRLIKQKGFSFTMNDLAAALGTSKRTLYAYYSSKD QLVEAVVEQFIAEMKQIERDIYENESLNVLEKVKQMLISLPQGMELLNMGLLNELKKY HYDAWLTLDAFIKEEWAIVLALLNECKQQKRIRNINPDLFVHMYIGSINQVYDPEYPL KHQFTTGEVLESIVDVLFNGITADEEADAT*" gene complement(3269556..3270128) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" promotor_-10 complement(3270166..3270185) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3270171) /Source="Nicolas_upshifts" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" promotor_-35 complement(3270199..3270206) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3270239..3271033) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391239.1" /db_xref="EnsemblGenomes-Gn:BSU33590" /db_xref="EnsemblGenomes-Tr:CAB15364" /db_xref="GOA:O32229" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14063" /db_xref="UniProtKB/Swiss-Prot:O32229" /translation="MKLNLQGKTALVTGSTSGIGKAIASSLAEEGAAVIINGRREEKV NQTIDELKTQHAEAVLYPAAFDLGTEEGCNELFQAYPEVDILVNNLGIFEPAEYFDIP DDEWFRFFEVNIMSGVRLTRRYLHNMIEKKEGRVIFIASEAAIMPSQEMAHYSATKTM QLSISRSLAELATGTNVTVNTVMPGSTLTEGVETMLNSLYPGENLTVQEAEARFMKEN RPTSIIQRLIRPEEIAHFVTFLSSPLSSAINGAALRADGGLVRSVF*" gene complement(3270239..3271033) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" promotor_-10 complement(3271054..3271072) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3271066) /Source="Nicolas_upshifts" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" promotor_-35 complement(3271087..3271093) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3271099..3271118) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3271110) /Source="Nicolas_upshifts" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" S_feature complement(3271112..3271177) /Source="Nicolas_S_feature" /locus_tag="new_3450605_3450670_c" /HighExp="H2O2, Heat, Diami, G180, Paraq, dia15, Oxctl, BMM, G135, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.47, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="0.996, 1" /label="S1285" promotor_-35 complement(3271132..3271139) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(3271219..3271578) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" /product="transfer-messenger RNA (tmRNA, 10Sa RNA)" /experiment="publication(s) with functional evidences, PMID:11395451, 11918677, 14766921, 17369301, 18673456" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11918677, 14766921, 17369301, 18673456" gene complement(3271219..3271578) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" downshifts complement(3271222) /Source="Nicolas_upshifts" /id="D1745" /incds=0 /nref=260 /ntot=272 /MaxReadThrough="4.32959" /MaxDrop="9.81359" /score="26.7868133" /energy="-15.8" /TU="U2642,U2644" /idTUdmin="U2643" /TUdmin="-2" /isTUend="TRUE" promotor_-10 complement(3271562..3271570) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3271572) /Source="Nicolas_upshifts" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" promotor_-35 complement(3271585..3271590) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3271630..3271649) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3271638) /Source="Nicolas_upshifts" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" S_feature complement(3271640..3271704) /Source="Nicolas_S_feature" /locus_tag="new_3451133_3451197_c" /HighExp="Etha, C90, dia5, dia15, Diami, T0.0H, T-0.40H, T-1.40H, LPhT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.997, 0.996, 1" /TUlongSig="SigB, SigA" /TUlongPSig="0.999, 0.753" /label="S1286" promotor_-35 complement(3271662..3271666) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3271704) /Source="Nicolas_upshifts" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" promotor_-10 complement(3271705..3271724) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-10" promotor_-35 complement(3271739..3271746) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-35" CDS complement(3271755..3272225) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10947848, 11395451, 11918677, 12682299, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10947848, 11395451, 11918677, 12682299, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="tmRNA-binding protein" /protein_id="NP_391240.1" /db_xref="EnsemblGenomes-Gn:BSU33600" /db_xref="EnsemblGenomes-Tr:CAB15365" /db_xref="GOA:O32230" /db_xref="InterPro:IPR000037" /db_xref="InterPro:IPR020081" /db_xref="InterPro:IPR023620" /db_xref="SubtiList:BG14064" /db_xref="UniProtKB/Swiss-Prot:O32230" /translation="MPKGSGKVLSQNKKANHDYFIEETYETGIVLQGTEIKSIRAGRV NLKDSFAKIERGEVFLHNMHVSPYEQGNRYNHDPLRTRKLLMHRKEINKLIGLTKEKG YSLVPLKLYLKNGFAKVLLGLGKGKKNYDKREDLKRKDAKREIERAFRDSQKGF*" gene complement(3271755..3272225) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" promotor_no_box 3272052..3272152 /Source="Nicolas_upshift_promotors" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3272112 /Source="Nicolas_upshifts" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 3272222 /Source="Nicolas_upshifts" /id="D1746" /incds=0 /nref=2 /ntot=105 /MaxReadThrough="0.62459" /MaxDrop="3.18501" /score="-9.3042809" /energy="-3.3" /TU="NA" /idTUdmin="U2647" /TUdmin="-1408" /isTUend="FALSE" promotor_-10 complement(3272270..3272289) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(3272276) /Source="Nicolas_upshifts" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" S_feature complement(3272278..3272369) /Source="Nicolas_S_feature" /locus_tag="new_3451771_3451862_c" /HighExp="Etha, S8, Cold, S7, G135, G180, G150, H2O2, M9-stat, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig="0.753" /label="S1287" promotor_-35 complement(3272305..3272308) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" CDS complement(3272370..3274709) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" /EC_number="3.1.13.1" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 19215769, 22333191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 19215769, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease R" /protein_id="NP_391241.1" /db_xref="EnsemblGenomes-Gn:BSU33610" /db_xref="EnsemblGenomes-Tr:CAB15366" /db_xref="GOA:O32231" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004476" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR011805" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013223" /db_xref="InterPro:IPR022966" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14065" /db_xref="UniProtKB/Swiss-Prot:O32231" /translation="MEKEAFMEKLLSFMKEEAYKPLTVQELEEMLNITEAEEFKELVK ALVALEEKGLIVRTRSDRYGIPEKMNLIKGKISAHAKGFAFLLPEDTSLSDVFIPPNE LNTAMNGDIVMVRLNSQSSGSRQEGTVIRILERAIQRVVGTYTETRNFGFVIPDDKKI TSDIFIPKNGKNGAAEGHKVVVKLTSYPEGRMNAEGEVETILGHKNDPGIDILSVIHK HGLPGEFPADAMEQASSTPDTIDEKDLKDRRDLRDQVIVTIDGADAKDLDDAVTVTKL DDGSYKLGVHIADVSHYVTENSPIDKEALERGTSVYLVDRVIPMIPHRLSNGICSLNP KVDRLTLSCEMTINSQGQVTEHEIFQSVIKTTERMTYSDVNKILVDDDEELKQKYEPL VPMFKDMERLAQILRDKRMDRGAVDFDFKEAKVLVDDEGAVKDVVIRERSVAEKLIEE FMLVANETVAEHFHWMNVPFIYRIHEEPNAEKLQKFLEFVTTFGYVVKGTAGNIHPRA LQSILDAVRDRPEETVISTVMLRSMKQAKYDPQSLGHFGLSTEFYTHFTSPIRRYPDL IVHRLIRTYLINGKVDEATQEKWAERLPDIAEHTSSMERRAVDAERETDDLKKAEYML DKIGEEFDGMISSVTNFGMFVELPNTIEGLVHVSFMTDDYYRFDEQHFAMIGERTGNV FRIGDEITVKVVDVNKDERNIDFEIVGMKGTPRRPRELDSSRSRKRGKPARKRVQSTN TPVSPAPSEEKGEWFTKPKKKKKKRGFQNAPKQKRKKKK*" gene complement(3272370..3274709) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" promotor_-35 3273470..3273473 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3273489..3273492 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3273498 /Source="Nicolas_upshifts" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3274728..3275468) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1369099, 17369301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase" /protein_id="NP_391242.2" /db_xref="EnsemblGenomes-Gn:BSU33620" /db_xref="EnsemblGenomes-Tr:CAB15367" /db_xref="GOA:O32232" /db_xref="InterPro:IPR012354" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14066" /db_xref="UniProtKB/Swiss-Prot:O32232" /translation="MKVVTPKPFTFKGGDKAVLLLHGFTGNTADVRMLGRYLNERGYT CHAPQYEGHGVPPEELVHTGPEDWWKNVMDGYEYLKSEGYESIAACGLSLGGVFSLKL GYTVPIKGIVPMCAPMHIKSEEVMYQGVLSYARNYKKFEGKSPEQIEEEMKEFEKTPM NTLKALQDLIADVRNNVDMIYSPTFVVQARHDHMINTESANIIYNEVETDDKQLKWYE ESGHVITLDKERDLVHQDVYEFLEKLDW*" gene complement(3274728..3275468) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" promotor_-10 complement(3275124..3275142) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-10" upshifts complement(3275136) /Source="Nicolas_upshifts" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" promotor_-35 complement(3275157..3275163) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-35" misc_feature complement(3275496..3275514) /Source="Nicolas_upshift_promotors" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3275510) /Source="Nicolas_upshifts" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" downshifts complement(3275598) /Source="Nicolas_upshifts" /id="D1747" /incds=0 /nref=30 /ntot=212 /MaxReadThrough="6.16751" /MaxDrop="5.2246" /score="-4.14736839" /energy="-9.1" /TU="U2650" /idTUdmin="U2649" /TUdmin="-3234" /isTUend="FALSE" CDS complement(3275600..3275830) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10074070, 10644701, 16243836" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074070, 10644701, 16243836; Product type f: factor" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_391243.1" /db_xref="EnsemblGenomes-Gn:BSU33630" /db_xref="EnsemblGenomes-Tr:CAB15368" /db_xref="GOA:O32233" /db_xref="InterPro:IPR004692" /db_xref="SubtiList:BG14067" /db_xref="UniProtKB/Swiss-Prot:O32233" /translation="MHAVLITLLVIVSIALIIVVLLQSSKSAGLSGAISGGAEQLFGK QKARGLDLILHRITVVLAVLFFVLTIALAYIL*" gene complement(3275600..3275830) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" promotor_-10 complement(3275860..3275879) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(3275881) /Source="Nicolas_upshifts" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" promotor_-35 complement(3275894..3275897) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" promotor_-35 3275919..3275925 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3275939..3275950 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3275940 /Source="Nicolas_upshifts" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" CDS 3275979..3276749 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391244.1" /db_xref="EnsemblGenomes-Gn:BSU33640" /db_xref="EnsemblGenomes-Tr:CAB15369" /db_xref="GOA:O32234" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14068" /db_xref="UniProtKB/Swiss-Prot:O32234" /translation="MPLISIDSRKHLFYEEYGQGIPIIFIHPPGMGRKVFYYQRLLSK HFRVIFPDLSGHGDSDHIDQPASISYYANEIAQFMDALHIDKAVLFGYSAGGLIAQHI GFTRPDKVSHLILSGAYPAVHNVIGQKLHKLGMYLLEKNPGLLMKILAGSHTKDRQLR SILTDHMKKADQAHWHQYYLDSLGYNCIEQLPRLEMPMLFMYGGLRDWTFTNAGYYRR SCRHAEFFRLEYQGHQLPTKQWKTCNELVTGFVLTHHS*" gene 3275979..3276749 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" promotor_-35 3276001..3276009 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3276020..3276038 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3276050 /Source="Nicolas_upshifts" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3276789..3277022) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional regulator" /protein_id="NP_391245.1" /db_xref="EnsemblGenomes-Gn:BSU33650" /db_xref="EnsemblGenomes-Tr:CAB15370" /db_xref="GOA:O32235" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG14159" /db_xref="UniProtKB/Swiss-Prot:O32235" /translation="MPVEKIQIRRDYVLQYMVNNDYSLNQLALEIGVSPATLSRVLNG ERRPGQLVIGKMLHYFNLKFEDLFYYDFVDKSQ*" gene complement(3276789..3277022) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" promotor_-35 3277113..3277120 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-35" upshifts 3277128 /Source="Nicolas_upshifts" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" promotor_-10 3277132..3277151 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-10" CDS 3277174..3277581 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16553878, 17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_391246.1" /db_xref="EnsemblGenomes-Gn:BSU33660" /db_xref="EnsemblGenomes-Tr:CAB15371" /db_xref="GOA:O32236" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14069" /db_xref="UniProtKB/Swiss-Prot:O32236" /translation="MESFGEQLRALREERKLTVNQLATYSGVSAAGISRIENGKRGVP KPATIKKLAEALKIPYEGLMYKAGYIEEVHEARAPYETKCKLLEKAEAYDLKNLALLE NEKWQYLNKEDLLMLDHYFSFISDEAKKRSADD*" gene 3277174..3277581 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" CDS 3277611..3278030 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional repressor" /protein_id="NP_391247.1" /db_xref="EnsemblGenomes-Gn:BSU33670" /db_xref="EnsemblGenomes-Tr:CAB15372" /db_xref="GOA:O32237" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14070" /db_xref="UniProtKB/Swiss-Prot:O32237" /translation="MSPFGQQLRELRRARKLTVNQLAVYSGISSATISKIENGKRGTP KPATIKKLAAVLKVPYENLMAAAGHIQAFPEEIREASEGYQSVYEIYQTAVTRGAEHL PIFNSQKWEHLSKQDIENLSKYFDFLSSEAKKRASSS*" gene 3277611..3278030 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" promotor_-35 3278068..3278075 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3278089..3278108 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3278096 /Source="Nicolas_upshifts" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" CDS 3278122..3278448 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20639328; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catechol dioxygenase" /protein_id="NP_391248.2" /db_xref="EnsemblGenomes-Gn:BSU33680" /db_xref="EnsemblGenomes-Tr:CAB15373" /db_xref="GOA:O32238" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14071" /db_xref="UniProtKB/Swiss-Prot:O32238" /translation="MNQSEMCPRFEKAVDILSKRWVALIVFQLLNGSQRFSEIEAALP NLSGRVLSERLKELELEGVVKRDVIPETPVRIEYSLTDKGKALAPILGEISKWATEWI DPSFLD*" gene 3278122..3278448 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" S_feature 3278449..3278533 /Source="Nicolas_S_feature" /locus_tag="new_3457942_3458026" /HighExp="Cold, H2O2, Diami, LBGstat, LPhT, dia15, G180, Paraq, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.985" /label="S1288" promotor_-35 3278504..3278511 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3278524..3278542 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3278535 /Source="Nicolas_upshifts" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" CDS 3278573..3280273 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8188684, 11872722, 27899502; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative methyl-accepting transducer" /protein_id="NP_391249.1" /db_xref="EnsemblGenomes-Gn:BSU33690" /db_xref="EnsemblGenomes-Tr:CAB15374" /db_xref="GOA:O32239" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR024478" /db_xref="InterPro:IPR035440" /db_xref="SubtiList:BG14072" /db_xref="UniProtKB/Swiss-Prot:O32239" /translation="MRLTISRKFSLVFLTLILINLLVGGIGVLNMQHIIQKTDEINTK WIDGIKGITSINYVTEHLSSKEKDFLIYTDKSKMDTLDQEMNQIMEDINQKLDNYEKT ISTDKEQKLFEQLQTKVNTYMDIHAQIIESGRTNDMDKARGLLVQTEASFEDMKKTIT QLVDLNQEGSNTAVKETKAVYHKGLIYTALLVAASILISIFIWLYITRNIVKPIIRMK ESANHIAEGDLSNDMEALNSKDELGDLNEALQKMVGNLRDIVGYSKDISSRVLSSSQV LATATNETRSGSKHITETMNEMAEGSEQQAQDAVTIAESMNEFTESIDKAYNHGITIS DTSQNVLELAVSGNENMATSLQQMKTIHHIVEEAVHKVRSLEQHSQDINKLVQVINGI AEQTNLLSLNAAIEAARAGESGKGFAVVAEEVRKLADGVSDSVQDITRIVNGTQQEIH TVITYLESSFTEVEKGTENLTDTGQAMQHIKQSVTHVADSIKEVTDGLKQLTNQSITI NQSIENIASVSEESAAGIEETFSITEQSAHSMDQVLLNAEELEQLANELNEKMGQFTI *" gene 3278573..3280273 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" S_feature complement(3279289..3280282) /Source="Nicolas_S_feature" /locus_tag="new_3458782_3459775_c" /HighExp="S6, S5, S7, C30, S8, S4, S3, LoTm, BT, B36" /AntisenseName="yvaQ" /AntisenseCor="-0.38660715434937498" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1289" downshifts 3280251 /Source="Nicolas_upshifts" /id="D1748" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="1.43789" /MaxDrop="3.86744" /score="26.1532813" /energy="-12.2" /TU="NA" /idTUdmin="U2655" /TUdmin=0 /isTUend="TRUE" CDS complement(3280313..3280993) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391250.1" /db_xref="EnsemblGenomes-Gn:BSU33700" /db_xref="EnsemblGenomes-Tr:CAB15375" /db_xref="GOA:P39775" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12636" /db_xref="UniProtKB/Swiss-Prot:P39775" /translation="MNVLEQLMTYYAQNGSYVMDEFGRHFLMSAYGVLFAAVVGVPAG ILIAHFRRLSAWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDMIVRGSNATNGTAIILAGAIPTAVMAVGADLLMAWLERALSPVKKKRTG AKHVQSAA*" gene complement(3280313..3280993) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" downshifts complement(3280327) /Source="Nicolas_upshifts" /id="D1749" /incds=0 /nref=119 /ntot=171 /MaxReadThrough="3.12805" /MaxDrop="5.39624" /score="35.0134287" /energy="-12.2" /TU="NA" /idTUdmin="U2657" /TUdmin=0 /isTUend="TRUE" promotor_-35 3280687..3280693 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3280708..3280726 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3280713..3283464 /Source="Nicolas_S_feature" /locus_tag="new_3460206_3462957" /HighExp="Sw, M9-stat, B60, Salt, LoTm, T0.30H, BC, Gly, B36, T1.0H" /AntisenseName="opuBC" /AntisenseCor="-0.13125567572652899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1290" upshifts 3280713 /Source="Nicolas_upshifts" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" CDS complement(3281010..3281930) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (choline-binding lipoprotein)" /protein_id="NP_391251.1" /db_xref="EnsemblGenomes-Gn:BSU33710" /db_xref="EnsemblGenomes-Tr:CAB15376" /db_xref="GOA:Q45462" /db_xref="InterPro:IPR007210" /db_xref="PDB:3R6U" /db_xref="SubtiList:BG12635" /db_xref="UniProtKB/Swiss-Prot:Q45462" /translation="MKRKYLKLMIGLALAATLTLSGCSLPGLSAAADQTIKIGAQSMS ESEIIASMLGQLIEHHTDLKTTTIKNLGSNAVQQQALMNGEIDIAATRYTGDALTGTL RMEPEKDPDKALALTQREFKKRYDLKWYDSYGFDNTYAFTVSKELADQYHLETVSDVK KWAPQLKLGVDNYWMKLKGNGYQDFTKTYGMTFGGTYPMQIGLVYDAVKSGKMDIVLA YSTDGRIKSYGLKMLKDDKQFFPPYDCSPVVPEKVLKEHPELEGIIKKMLGKIDTATM QELNYEVDGNLKEPSVVAKEYLEKHRYFES*" gene complement(3281010..3281930) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" CDS complement(3281942..3282595) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391252.1" /db_xref="EnsemblGenomes-Gn:BSU33720" /db_xref="EnsemblGenomes-Tr:CAB15377" /db_xref="GOA:Q45461" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12634" /db_xref="UniProtKB/Swiss-Prot:Q45461" /translation="MHHIVQFLQTNGGELLYKTYEHITISLIAVILGVLVAVPLGVVL TRMKKGAGTIIGIVNIIQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIRGVNKNLLESGKGIGMTPAEQVRLVELPLAAPVIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIVIDYVLAVAERKLTPAGMQRLKELS* " gene complement(3281942..3282595) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" CDS complement(3282612..3283757) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 18321243, 21658392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 18321243, 21658392; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (ATP-binding protein)" /protein_id="NP_391253.1" /db_xref="EnsemblGenomes-Gn:BSU33730" /db_xref="EnsemblGenomes-Tr:CAB15378" /db_xref="GOA:Q45460" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12633" /db_xref="UniProtKB/Swiss-Prot:Q45460" /translation="MLTLENVSKTYKGGKKAVNNVNLKIAKGEFICFIGPSGCGKTTT MKMINRLIEPSAGKIFIDGENIMDQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEQQRKERARELLKLVDMGPEYVDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQKTLHKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDDILRNPADEFVEEFIGKERLIQSSSPDVERVDQIMNTQPVTITADKTLSEAIQLM RQERVDSLLVVNDERVLQGYVDVEIIDQCRKKANLVSEVLHEDIYTVLGGTLLRDTVR KILKRGVKYVPVVDEDRRLIGIVTRASLVDIVYDSLWGEEKQLAALS*" gene complement(3282612..3283757) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" S_feature complement(3283758..3283825) /Source="Nicolas_S_feature" /locus_tag="new_3463251_3463318_c" /HighExp="T5.0H, T3.30H, T3.0H, T-5.40H, T4.0H, T-0.40H, T-1.40H, T2.30H, T-3.40H, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1291" upshifts complement(3283825) /Source="Nicolas_upshifts" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" promotor_-10 complement(3283826..3283845) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3283856..3283860 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3283860..3283863) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3283876..3283894 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3283881 /Source="Nicolas_upshifts" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" promotor_-35 3283976..3283980 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3283996..3284015 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3283999 /Source="Nicolas_upshifts" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" CDS 3284041..3284574 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (controlling choline uptake)" /protein_id="NP_391254.2" /db_xref="EnsemblGenomes-Gn:BSU33740" /db_xref="EnsemblGenomes-Tr:CAB15379" /db_xref="GOA:C0SPB8" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14073" /db_xref="UniProtKB/Swiss-Prot:C0SPB8" /translation="MEKDPLTIIEQAEDHFIERIAENMHAFGMPSTVGRVLGIIYMNR KPMTLTELSEATGMSKTRMSQVVREMLDANIAEKVFEKGVRKDLYEVEQDYYQTFITL FSATWSKVVSKNKMMHKKLNRELLSVLDEELTPEAEEKVNELLKELKEWLDYYNWLSR LIEFFESEDIFKYVPKP*" gene 3284041..3284574 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" S_feature complement(3284241..3284760) /Source="Nicolas_S_feature" /locus_tag="new_3463734_3464253_c" /HighExp="S8, Cold, C30, GM 25, GM 60, BC, T-4.40H, M/G, GM-0.1, MG 120" /AntisenseName="yvaV" /AntisenseCor="-7.6123637680436104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.503, 1, 0.758" /TUlongSig="NA" /TUlongPSig="NA" /label="S1292" downshifts 3284563 /Source="Nicolas_upshifts" /id="D1750" /incds=0 /nref=51 /ntot=161 /MaxReadThrough="2.68472" /MaxDrop="4.69377" /score="-3.5823381" /energy="-8.6" /TU="NA" /idTUdmin="U2659" /TUdmin=0 /isTUend="TRUE" promotor_-35 3284697..3284704 /Source="Nicolas_upshift_promotors" /id="U2660" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2868 /SigmaFactorBS="taatgcataatttacattaatttattaattatccatttttTG TTGATTattctgactagctaTTATATAATCTTTTTGAAATgattatattagcttagag g" /listShort="S1293, sdpA, sdpB, spbC, S1297" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3284717..3284795 /Source="Nicolas_S_feature" /locus_tag="new_3464210_3464288" /HighExp="T-1.10H, T2.30H, T4.0H, T5.0H, T-2.40H, T2.0H, T-0.40H, M9-stat, T-5.40H, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1293" upshifts 3284717 /Source="Nicolas_upshifts" /id="U2660" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2868 /SigmaFactorBS="taatgcataatttacattaatttattaattatccatttttTG TTGATTattctgactagctaTTATATAATCTTTTTGAAATgattatattagcttagag g" /listShort="S1293, sdpA, sdpB, spbC, S1297" /GFF_Attribute="listLong" promotor_-10 3284719..3284738 /Source="Nicolas_upshift_promotors" /id="U2660" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2868 /SigmaFactorBS="taatgcataatttacattaatttattaattatccatttttTG TTGATTattctgactagctaTTATATAATCTTTTTGAAATgattatattagcttagag g" /listShort="S1293, sdpA, sdpB, spbC, S1297" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3284745..3284759) /Source="Nicolas_upshift_promotors" /id="U2661" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.483516483516484" /psig="0.503496503496504" /xcortree=2951 /SigmaFactorBS="aaaataataggaaacatatagtcattacagtaataattccct tttttttgaTgtagattacCTCCTCTAAGCTAATataatcatttcaaaaagattatat a" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3284760) /Source="Nicolas_upshifts" /id="U2661" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.483516483516484" /psig="0.503496503496504" /xcortree=2951 /SigmaFactorBS="aaaataataggaaacatatagtcattacagtaataattccct tttttttgaTgtagattacCTCCTCTAAGCTAATataatcatttcaaaaagattatat a" /listShort="S1292" /GFF_Attribute="listLong" promotor_-35 complement(3284769) /Source="Nicolas_upshift_promotors" /id="U2661" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.483516483516484" /psig="0.503496503496504" /xcortree=2951 /SigmaFactorBS="aaaataataggaaacatatagtcattacagtaataattccct tttttttgaTgtagattacCTCCTCTAAGCTAATataatcatttcaaaaagattatat a" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3284796..3285272 /gene="sdpA" /locus_tag="BSU_33750" /old_locus_tag="BSU33750" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16469701, 17069462, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16469701, 17069462, 23687264; Product type f: factor" /codon_start=1 /transl_table=11 /product="export step of killing factor SdpC" /protein_id="NP_391255.1" /db_xref="EnsemblGenomes-Gn:BSU33750" /db_xref="EnsemblGenomes-Tr:CAB15380" /db_xref="GOA:O34889" /db_xref="InterPro:IPR023902" /db_xref="SubtiList:BG14074" /db_xref="UniProtKB/Swiss-Prot:O34889" /translation="MTICFLLFSSYYFSNISPQNPLFKKNFLQQLSPQGFGFYSKSPT EENISFHTKENLKLPNALPNNFFGIKREGRVQAIELGKIVENIDPKNWKTCENNNSCT NLEKQIKPIKVIKNEDYIHLSKGEYLIYRQKPLSWYWIDFKQTTSFERKVLKIKIV*" gene 3284796..3285272 /gene="sdpA" /locus_tag="BSU_33750" /old_locus_tag="BSU33750" promotor_-10 complement(3284821..3284840) /Source="Nicolas_upshift_promotors" /id="U2662" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=3097 /SigmaFactorBS="agacaattgttgcaaaaaattttttttgaacaGTGGATTCtg aggtgaaatATTGCTAAAGTAATAAGAAGaaaataataggaaacatatagtcattaca g" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3284831) /Source="Nicolas_upshifts" /id="U2662" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=3097 /SigmaFactorBS="agacaattgttgcaaaaaattttttttgaacaGTGGATTCtg aggtgaaatATTGCTAAAGTAATAAGAAGaaaataataggaaacatatagtcattaca g" /listShort="S1292" /GFF_Attribute="listLong" promotor_-35 complement(3284852..3284859) /Source="Nicolas_upshift_promotors" /id="U2662" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=3097 /SigmaFactorBS="agacaattgttgcaaaaaattttttttgaacaGTGGATTCtg aggtgaaatATTGCTAAAGTAATAAGAAGaaaataataggaaacatatagtcattaca g" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3285269..3286240 /gene="sdpB" /locus_tag="BSU_33760" /old_locus_tag="BSU33760" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16469701, 16850406, 17069462, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16469701, 16850406, 17069462, 23687264; Product type t : transporter" /codon_start=1 /transl_table=11 /product="export step of killing factor SdpC" /protein_id="NP_391256.1" /db_xref="EnsemblGenomes-Gn:BSU33760" /db_xref="EnsemblGenomes-Tr:CAB15381" /db_xref="GOA:O34616" /db_xref="InterPro:IPR007782" /db_xref="InterPro:IPR011020" /db_xref="InterPro:IPR023894" /db_xref="SubtiList:BG14075" /db_xref="UniProtKB/Swiss-Prot:O34616" /translation="MKILNSLEGYIDTYNPWKNTYALFRSLLGFSTLLVLLFNSTDIL FSYSANNVTCENVYIPTAFCFAKEYSINFEIIRYLMIFILTLVVIGWRPRFTGLFHWY ICYSIQTSALTIDGGEQIATVLSFLILPVTLLDSRRNHWNIKKNNNESFTKKTVLFYI MTIIKIQVFIIYLNAALERLKNKEWAEGTAIYYFFSDPVFGLPEYQLNLMNPLLESNF IVVITWLVTIFELFLAASIISNIRIKRIALVLGILFHIGIIFSIGIVSFGLIMISALI IYLHPVQQNITMNWCSPLFKYIYVKGKRNFKRIGGESVKFLTKLFHS*" gene 3285269..3286240 /gene="sdpB" /locus_tag="BSU_33760" /old_locus_tag="BSU33760" promotor_no_box 3286077..3286177 /Source="Nicolas_upshift_promotors" /id="U2663" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.457542457542458" /psig="0.636363636363636" /xcortree=2869 /SigmaFactorBS="tcatgatatcagcattaattatatatctgcatcctgtacaac aaaatatcactatgaattggtgttctcctttatttaaatatatatatgtaaaaggaaa g" /listShort="spbC, S1297" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3286137 /Source="Nicolas_upshifts" /id="U2663" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.457542457542458" /psig="0.636363636363636" /xcortree=2869 /SigmaFactorBS="tcatgatatcagcattaattatatatctgcatcctgtacaac aaaatatcactatgaattggtgttctcctttatttaaatatatatatgtaaaaggaaa g" /listShort="spbC, S1297" /GFF_Attribute="listLong" promotor_-10 complement(3286149..3286166) /Source="Nicolas_upshift_promotors" /id="U2664" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.758241758241758" /xcortree=423 /SigmaFactorBS="aacaattttgtaagaaacttgactgattcacctcctattctt ttgAAAtttctctttccttttaCATATATATATTTAAATAaaggagaacaccaattca t" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3286170) /Source="Nicolas_upshifts" /id="U2664" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.758241758241758" /xcortree=423 /SigmaFactorBS="aacaattttgtaagaaacttgactgattcacctcctattctt ttgAAAtttctctttccttttaCATATATATATTTAAATAaaggagaacaccaattca t" /listShort="S1292" /GFF_Attribute="listLong" S_feature complement(3286172..3286574) /Source="Nicolas_S_feature" /locus_tag="new_3465665_3466067_c" /HighExp="Gly, Lbstat, BT, S8, T1.30H, C30, M9-stat, C90, Sw, HiTm" /AntisenseName="spbC" /AntisenseCor="-0.16053929530879699" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1294" promotor_-35 complement(3286183..3286185) /Source="Nicolas_upshift_promotors" /id="U2664" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.758241758241758" /xcortree=423 /SigmaFactorBS="aacaattttgtaagaaacttgactgattcacctcctattctt ttgAAAtttctctttccttttaCATATATATATTTAAATAaaggagaacaccaattca t" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3286201) /Source="Nicolas_upshifts" /id="D1751" /incds=0 /nref=1 /ntot=33 /MaxReadThrough="3.26001" /MaxDrop="4.09728" /score="-7.06061287" /energy="-10.3" /TU="NA" /idTUdmin="U2665" /TUdmin=286 /isTUend="FALSE" CDS 3286283..3286894 /gene="spbC" /locus_tag="BSU_33770" /old_locus_tag="BSU33770" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:15743949, 16469701, 17069462, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 16469701, 17069462, 23687264; Product type f: factor" /codon_start=1 /transl_table=11 /product="precursor of killing factor SdpC" /protein_id="NP_391257.1" /db_xref="EnsemblGenomes-Gn:BSU33770" /db_xref="EnsemblGenomes-Tr:CAB15382" /db_xref="GOA:O34344" /db_xref="InterPro:IPR023888" /db_xref="SubtiList:BG14076" /db_xref="UniProtKB/Swiss-Prot:O34344" /translation="MKSKLLRLLIVSMVTILVFSLVGLSKESSTSAKENHTFSGEDYF RGLLFGQGEVGKLISNDLDPKLVKEANSTEGKKLVNDVVKFIKKDQPQYMDELKQSID SKDPKKLIENMTKADQLIQKYAKKNENVKYSSNKVTPSCGLYAVCVAAGYLYVVGVNA VALQTAAAVTTAVWKYVAKYSSSASNNSDLEAAAAKTLKLIHQ*" gene 3286283..3286894 /gene="spbC" /locus_tag="BSU_33770" /old_locus_tag="BSU33770" S_feature complement(3286576..3286662) /Source="Nicolas_S_feature" /locus_tag="new_3466069_3466155_c" /HighExp="T1.30H, Gly, T2.0H, BT, S8, C30, Lbstat, C90, T1.0H, M9-stat" /AntisenseName="spbC" /AntisenseCor="-5.4790207146846799E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1295" downshifts complement(3286619) /Source="Nicolas_upshifts" /id="D1752" /incds=1 /nref=1 /ntot=8 /MaxReadThrough="4.62458" /MaxDrop="2.00358" /score="8.72167152" /energy="-11.6" /TU="U2665" /idTUdmin="U2665" /TUdmin="-132" /isTUend="FALSE" S_feature complement(3286664..3286849) /Source="Nicolas_S_feature" /locus_tag="new_3466157_3466342_c" /HighExp="T1.30H, T2.0H, M9-stat, T1.0H, B60, T2.30H, T5.0H, B36, T3.30H, T0.30H" /AntisenseName="spbC" /AntisenseCor="-4.2394313806342503E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1296" downshifts complement(3286707) /Source="Nicolas_upshifts" /id="D1753" /incds=1 /nref=1 /ntot=14 /MaxReadThrough="4.27088" /MaxDrop="2.27366" /score="8.72167152" /energy="-11.6" /TU="U2665" /idTUdmin="U2665" /TUdmin="-220" /isTUend="FALSE" downshifts 3286874 /Source="Nicolas_upshifts" /id="D1754" /incds=0 /nref=207 /ntot=252 /MaxReadThrough="4.65014" /MaxDrop="7.52715" /score="19.8036228" /energy="-20" /TU="U2660,U2663" /idTUdmin="U2660" /TUdmin="-1099" /isTUend="FALSE" downshifts complement(3286894) /Source="Nicolas_upshifts" /id="D1755" /incds=0 /nref=14 /ntot=94 /MaxReadThrough="6.14809" /MaxDrop="5.58575" /score="8.72167152" /energy="-11.6" /TU="U2665" /idTUdmin="U2667" /TUdmin=33 /isTUend="FALSE" S_feature 3286919..3288057 /Source="Nicolas_S_feature" /locus_tag="new_3466412_3467550" /HighExp="Pyr, S8, nit, C30, GM 150, M9-stat, S7, S2, G/S, S1" /AntisenseName="sdpI" /AntisenseCor="-7.9710115369408502E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.636, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1297" CDS complement(3286941..3287564) /gene="sdpI" /locus_tag="BSU_33780" /old_locus_tag="BSU33780" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12817086, 15849754, 16850406, 20563570, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12817086, 15849754, 16850406, 20563570, 23687264; Product type r: regulator" /codon_start=1 /transl_table=11 /product="integral membrane immunity regulator of autophagy" /protein_id="NP_391258.1" /db_xref="EnsemblGenomes-Gn:BSU33780" /db_xref="EnsemblGenomes-Tr:CAB15383" /db_xref="GOA:O32241" /db_xref="InterPro:IPR012867" /db_xref="InterPro:IPR025962" /db_xref="InterPro:IPR026272" /db_xref="SubtiList:BG14077" /db_xref="UniProtKB/Swiss-Prot:O32241" /translation="MKKNIISIIIVCLSFLTSIILYQYLPEEIPIQWSGNKPAAIVSK PLTIFIIPVVMLIYYLTFYMLTIKSTQKNKALLFLASNNMLILLYILQLSTLLISLGY EVNIDLIIGLGVGIFLIIGGNSMQLAEQNHLIGLRTPWTLKDETVWKLGNRFASKVLV VCGFIIAVLSFFTGEYIILIMIVLVLLALVISTLASYHYYKKLNGSR*" gene complement(3286941..3287564) /gene="sdpI" /locus_tag="BSU_33780" /old_locus_tag="BSU33780" downshifts complement(3286949) /Source="Nicolas_upshifts" /id="D1756" /incds=0 /nref=1 /ntot=95 /MaxReadThrough="6.43517" /MaxDrop="3.3455" /score="8.72167152" /energy="-11.6" /TU="U2665,U2667" /idTUdmin="U2667" /TUdmin="-22" /isTUend="TRUE" CDS complement(3287561..3287833) /gene="sdpR" /locus_tag="BSU_33790" /old_locus_tag="BSU33790" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12817086, 17069462, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12817086, 17069462, 23687264; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of SdpC synthesis operon (ArsR family)" /protein_id="NP_391259.1" /db_xref="EnsemblGenomes-Gn:BSU33790" /db_xref="EnsemblGenomes-Tr:CAB15384" /db_xref="GOA:O32242" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14078" /db_xref="UniProtKB/Swiss-Prot:O32242" /translation="MNNVFKAISDPTRRKILDLLKGGDMTAGDIAEHFNISKPSISHH LNILKQAEVISDHRKGQFIYYSLNTTVLQDSINWMLNFINKGDNDL*" gene complement(3287561..3287833) /gene="sdpR" /locus_tag="BSU_33790" /old_locus_tag="BSU33790" promotor_-10 complement(3287889..3287908) /Source="Nicolas_upshift_promotors" /id="U2665" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.372627372627373" /psig=1 /xcortree=405 /SigmaFactorBS="tacaaaaatcagatattataaccaatttgaggGTTGTTTtta aaaaaattCAAGTTATAATGAAAATAATacatttatacaaatatctaaatgtctaaat g" /listShort="sdpR, sdpI, S1296, S1295, S1294" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3287898) /Source="Nicolas_upshifts" /id="U2665" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.372627372627373" /psig=1 /xcortree=405 /SigmaFactorBS="tacaaaaatcagatattataaccaatttgaggGTTGTTTtta aaaaaattCAAGTTATAATGAAAATAATacatttatacaaatatctaaatgtctaaat g" /listShort="sdpR, sdpI, S1296, S1295, S1294" /GFF_Attribute="listLong" S_feature complement(3287900..3288048) /Source="Nicolas_S_feature" /locus_tag="new_3467393_3467541_c" /HighExp="Salt, B36, Gly, B60, LoTm, S8, GM 5, MG 25, Cold, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1298" promotor_-35 complement(3287920..3287926) /Source="Nicolas_upshift_promotors" /id="U2665" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.372627372627373" /psig=1 /xcortree=405 /SigmaFactorBS="tacaaaaatcagatattataaccaatttgaggGTTGTTTtta aaaaaattCAAGTTATAATGAAAATAATacatttatacaaatatctaaatgtctaaat g" /listShort="sdpR, sdpI, S1296, S1295, S1294" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3288053..3288742) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391260.1" /db_xref="EnsemblGenomes-Gn:BSU33800" /db_xref="EnsemblGenomes-Tr:CAB15385" /db_xref="GOA:O34742" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12640" /db_xref="UniProtKB/Swiss-Prot:O34742" /translation="MEVLQQLGTYYSQNGGYVLQEFYRHFLMSVYGVLFAAIVGIPLG ILIARYRRLSGWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDIIVRGSNATNGTAIILAGAIPTALMAVIADLVMGWLERALSPIKKKKGN FIIADRKTTSI*" gene complement(3288053..3288742) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" downshifts complement(3288093) /Source="Nicolas_upshifts" /id="D1757" /incds=0 /nref=95 /ntot=199 /MaxReadThrough="5.55394" /MaxDrop="6.7177" /score="8.72167152" /energy="-11.6" /TU="U2667" /idTUdmin="U2667" /TUdmin="-1166" /isTUend="FALSE" promotor_-35 3288685..3288693 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3288707..3288726 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3288721 /Source="Nicolas_upshifts" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3288760..3289671) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 28256787; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (osmoprotectant-binding lipoprotein)" /protein_id="NP_391261.1" /db_xref="EnsemblGenomes-Gn:BSU33810" /db_xref="EnsemblGenomes-Tr:CAB15386" /db_xref="GOA:O32243" /db_xref="InterPro:IPR007210" /db_xref="PDB:3PPN" /db_xref="PDB:3PPO" /db_xref="PDB:3PPP" /db_xref="PDB:3PPQ" /db_xref="PDB:3PPR" /db_xref="SubtiList:BG12639" /db_xref="UniProtKB/Swiss-Prot:O32243" /translation="MTKIKWLGAFALVFVMLLGGCSLPGLGGASDDTIKIGAQSMTES EIVANMIAQLIEHDTDLNTALVKNLGSNYVQHQAMLGGDIDISATRYSGTDLTSTLGK EAEKDPKKALNIVQNEFQKRFSYKWFDSYGFDNTYAFTVTKKFAEKEHINTVSDLKKN ASQYKLGVDNAWLKRKGDGYKGFVSTYGFEFGTTYPMQIGLVYDAVKNGKMDAVLAYS TDGRIKAYDLKILKDDKRFFPPYDCSPVIPEKVLKEHPELEGVINKLIGQIDTETMQE LNYEVDGKLKEPSVVAKEFLEKHHYFD*" gene complement(3288760..3289671) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" CDS complement(3289691..3290344) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391262.1" /db_xref="EnsemblGenomes-Gn:BSU33820" /db_xref="EnsemblGenomes-Tr:CAB15387" /db_xref="GOA:O34878" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12638" /db_xref="UniProtKB/Swiss-Prot:O34878" /translation="MNQMMTFLQTNGGELLYKTGEHLYISLIAVVLGIIVAVPLGVAL TRMKKGAGAVIGFVNIVQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIKGVNKNLLESGKGIGMTGWEQIRLVEIPLAIPIIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIIIDYVLAVTERKVTPKGLQGMKEVS* " gene complement(3289691..3290344) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" CDS complement(3290367..3291509) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10216873, 9925583, 21658392, 27378384, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216873, 9925583, 21658392, 27378384, 27683249; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (ATP-binding protein)" /protein_id="NP_391263.1" /db_xref="EnsemblGenomes-Gn:BSU33830" /db_xref="EnsemblGenomes-Tr:CAB15388" /db_xref="GOA:O34992" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12637" /db_xref="UniProtKB/Swiss-Prot:O34992" /translation="MLKLEQVSKVYKGGKKAVNSIDLDIAKGEFICFIGPSGCGKTTT MKMINRLIEPSSGRIFIDGENIMEQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEEKRKERARELLKLVDMGPEYLDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQRTLNKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDEILRNPANEFVEEFIGKERLIQSRPDIERVEQMMNRTPVTVSADKTLSQAIQLMR EKRVDSLLVVDRQNVLKGYVDVEMIDQNRKKASIVGDVYRSDIYTVQKGALLRDTVRK ILKQGIKYVPVVDEQNHLAGIVTRASLVDIVYDSIWGDEENQLMTI*" gene complement(3290367..3291509) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" promotor_-10 complement(3291553..3291572) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-10" upshifts complement(3291568) /Source="Nicolas_upshifts" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" promotor_-35 complement(3291587..3291590) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-35" promotor_-35 3291706..3291713 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3291726..3291745 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3291737 /Source="Nicolas_upshifts" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" CDS 3291773..3292330 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23960087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23960087; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative transcriptional regulator of choline uptake systems" /protein_id="NP_391264.1" /db_xref="EnsemblGenomes-Gn:BSU33840" /db_xref="EnsemblGenomes-Tr:CAB15389" /db_xref="GOA:O34709" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14079" /db_xref="UniProtKB/Swiss-Prot:O34709" /translation="MKKTALDIIEHAEEHLIEKIAENMHTFGMPSTVGRVLGIIYMNR KPMTLSELSEATGMSKTRMSQVVREMIDANIAEKVFEKGVRKDLYDVEQDYYQTFISL FAANWTKVVSKNKVLYKKLNRELSDLLQRDGLTPEAEEKVNQLLNELKEWLHYYDWLS RLIEFFESEEVFRYVPKTKECSSLK*" gene 3291773..3292330 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" S_feature 3292331..3293095 /Source="Nicolas_S_feature" /locus_tag="new_3471824_3472588" /HighExp="HiOs, GM 5, GM 10, Salt, MG 15, MG 10, MG 25, T0.0H, T-2.40H, GM 45" /AntisenseName="yvbG" /AntisenseCor="-0.14921239095219299" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1299" CDS complement(3292348..3292983) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391265.1" /db_xref="EnsemblGenomes-Gn:BSU33850" /db_xref="EnsemblGenomes-Tr:CAB15390" /db_xref="GOA:O32244" /db_xref="InterPro:IPR002771" /db_xref="SubtiList:BG14080" /db_xref="UniProtKB/Swiss-Prot:O32244" /translation="MMFSFIVHVFISLFAVSNPIGNVPIFLTLTEGYTAAERKAIARK AAILSFFILAAFLVFGHLIFKLFDINIHALRVAGGIFIFGIAYNLLNAKESHVQSLHH DEHKESKEKADISVTPLSIPIIAGPGTIATVMSLSAGHSGIGHYAAVMIGIAAVIALT FLFFHYSAFISSKLGKTEMNVITRLMGLILAVVAVGMIGAGLKGMFPVLTS*" gene complement(3292348..3292983) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" downshifts complement(3292361) /Source="Nicolas_upshifts" /id="D1758" /incds=0 /nref=21 /ntot=50 /MaxReadThrough="2.02169" /MaxDrop="4.45088" /score="10.9231366" /energy="-16.4" /TU="NA" /idTUdmin="U2669" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3293024..3293042) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3293030) /Source="Nicolas_upshifts" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" promotor_-35 complement(3293058..3293064) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3293069..3293076 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3293088..3293107 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3293097 /Source="Nicolas_upshifts" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" CDS 3293133..3293747 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391266.1" /db_xref="EnsemblGenomes-Gn:BSU33860" /db_xref="EnsemblGenomes-Tr:CAB15391" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR021722" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG14081" /db_xref="UniProtKB/Swiss-Prot:O32245" /translation="MFKKIAADALGLSDIGKIIEPQDYDKTDADDYVMHEDNEKIYFL IKTKADEYCFTNLALIHVDGERATSSKRTLKRYPYSQYKISDVFLETAGKVDLDVEIK FKLGGEQFDIDVHKDQIEKLKDLYKALLRIAETTYENDILINQAEQSLDKAVTILHHT RPEHVNIETQYKELTEFGFTWLTSVRSQYHIKDFGDVFEKYINN*" gene 3293133..3293747 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" downshifts 3293733 /Source="Nicolas_upshifts" /id="D1759" /incds=0 /nref=110 /ntot=197 /MaxReadThrough="2.66824" /MaxDrop="5.86088" /score="-4.16829989" /energy="-7.9" /TU="U2670" /idTUdmin="U2668" /TUdmin="-4" /isTUend="TRUE" promotor_-35 3293801..3293804 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3293819..3293838 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3293827 /Source="Nicolas_upshifts" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" CDS 3293879..3294577 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391267.1" /db_xref="EnsemblGenomes-Gn:BSU33870" /db_xref="EnsemblGenomes-Tr:CAB15392" /db_xref="GOA:O32246" /db_xref="InterPro:IPR029038" /db_xref="SubtiList:BG14082" /db_xref="UniProtKB/Swiss-Prot:O32246" /translation="MYCPQCGHQTDGGNFCEKCGSPLPGQSGHQHAAQTGAAAKQAAK QFGSFVLSVLKRPYQECKATGGEQLISAIITMVLFSLLTPLMFYILFSDGPGSVSFTA IFLEPTIYFILFLFGLHACIFFALKIAGNQVSFKDSFSRFGAFLIPFTAILILALFFF LLHTDICFTILAVGLIGAFFAIPPAMLSSYQHSYKGKVDFIYSTIVIYLIICVTFQLI IEHYVKEIFRYMLF*" gene 3293879..3294577 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" downshifts 3294550 /Source="Nicolas_upshifts" /id="D1760" /incds=0 /nref=72 /ntot=203 /MaxReadThrough="1.50622" /MaxDrop="4.71846" /score="17.2112529" /energy="-17.2" /TU="U2671" /idTUdmin="U2671" /TUdmin="-23" /isTUend="FALSE" CDS complement(3294613..3296430) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15155184" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391268.1" /db_xref="EnsemblGenomes-Gn:BSU33880" /db_xref="EnsemblGenomes-Tr:CAB15393" /db_xref="GOA:O32247" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR026870" /db_xref="SubtiList:BG14083" /db_xref="UniProtKB/Swiss-Prot:O32247" /translation="MLFCKNCGSQNNEGAKFCKQCGTPIGGGSKQANQETASTAETRQ APRKPIPKKTIILWSSIAAACVILFAAYKTGAYFTSKDRLVDKFEQAVNDGDQDQIAT LLTPVNDNLKLTKNNVKPFLTYLKDHPDKKDELFASLRDETAQKDIVYAEKDGKSLLV FDHYDLKVAPVYFEVSSNYKNTDLYVNKEEAGSVKKADQAQTLGPYIPGEYTVSAKLK NDVVDLVKKEDIQAIGDSSFRVDLSLEADDVTFSLANDIKSGKGDLLINGKSIHKDPF KSVTYGPLLTDGSMTASVEAEFPWGKTKTAGVPIDDKEMELTLIPDQDTQEQIMNTIV KTTKQYSKALSDGNTAQMTEASANWKAETKDTVDSMKSADSYLKDRYLETDFDLDTFA LSQKNDGTWQVSVTGKELHQSSSYNDYTKSEMTDDSPSYEYLLSYDKKQKKWIFEDAE STFESAGTNIKKIKNDKPETYTSAWAGSKNKGSESSASGDVTDEQVTLFMGSYLQSQA DAVNQNNFSLMEDSLEKGSSLYSDQQHLVSKLNKEGTTEDFNNYEVKSWSQNGSAITI KTYEEFYITKSGGSPKLRTYNWTYTGVVKNGRIYLTSIQ*" gene complement(3294613..3296430) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" downshifts complement(3294632) /Source="Nicolas_upshifts" /id="D1761" /incds=0 /nref=31 /ntot=189 /MaxReadThrough="2.6958" /MaxDrop="3.67366" /score="15.9345511" /energy="-17.2" /TU="NA" /idTUdmin="U2673" /TUdmin="-5" /isTUend="TRUE" downshifts complement(3294803) /Source="Nicolas_upshifts" /id="D1762" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="4.6758" /MaxDrop="2.2812" /score="15.9345511" /energy="-17.2" /TU="U2673" /idTUdmin="U2673" /TUdmin="-176" /isTUend="FALSE" misc_feature complement(3296472..3296491) /Source="Nicolas_upshift_promotors" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 3296476..3296495 /Source="Nicolas_upshift_promotors" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3296481 /Source="Nicolas_upshifts" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" upshifts complement(3296485) /Source="Nicolas_upshifts" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" CDS 3296550..3297017 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acyltransferase" /protein_id="NP_391269.1" /db_xref="EnsemblGenomes-Gn:BSU33890" /db_xref="EnsemblGenomes-Tr:CAB15394" /db_xref="GOA:O32248" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YVK" /db_xref="SubtiList:BG14084" /db_xref="UniProtKB/Swiss-Prot:O32248" /translation="MNMQKLRIELGEETNDELYDLLLLADPSKDIVDEYLERGECYTA WAGDELAGVYVLLKTRPQTVEIVNIAVKESLQKKGFGKQLVLDAIEKAKKLGADTIEI GTGNSSIHQLSLYQKCGFRIQAIDHDFFLRHYDEDIFENGIQCRDMVRLYLDL*" gene 3296550..3297017 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" downshifts 3297014 /Source="Nicolas_upshifts" /id="D1763" /incds=0 /nref=199 /ntot=250 /MaxReadThrough="1.84358" /MaxDrop="5.3321" /score="15.9040274" /energy="-13.3" /TU="U2672" /idTUdmin="U2672" /TUdmin="-23" /isTUend="FALSE" CDS complement(3297062..3298354) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" /EC_number="4.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enolase" /protein_id="NP_391270.1" /db_xref="EnsemblGenomes-Gn:BSU33900" /db_xref="EnsemblGenomes-Tr:CAB15395" /db_xref="GOA:P37869" /db_xref="InterPro:IPR000941" /db_xref="InterPro:IPR020809" /db_xref="InterPro:IPR020810" /db_xref="InterPro:IPR020811" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:4A3R" /db_xref="SubtiList:BG10899" /db_xref="UniProtKB/Swiss-Prot:P37869" /translation="MPYIVDVYAREVLDSRGNPTVEVEVYTETGAFGRALVPSGASTG EYEAVELRDGDKDRYLGKGVLTAVNNVNEIIAPELLGFDVTEQNAIDQLLIELDGTEN KGKLGANAILGVSMACARAAADFLQIPLYQYLGGFNSKTLPVPMMNIVNGGEHADNNV DIQEFMIMPVGAPNFREALRMGAQIFHSLKSVLSAKGLNTAVGDEGGFAPNLGSNEEA LQTIVEAIEKAGFKPGEEVKLAMDAASSEFYNKEDGKYHLSGEGVVKTSAEMVDWYEE LVSKYPIISIEDGLDENDWEGHKLLTERLGKKVQLVGDDLFVTNTKKLSEGIKNGVGN SILIKVNQIGTLTETFDAIEMAKRAGYTAVISHRSGETEDSTIADIAVATNAGQIKTG APSRTDRVAKYNQLLRIEDQLAETAQYHGINSFYNLNK*" gene complement(3297062..3298354) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" downshifts complement(3297072) /Source="Nicolas_upshifts" /id="D1764" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="2.21852" /MaxDrop="9.34136" /score="29.8674712" /energy="-15" /TU="NA" /idTUdmin="U2674" /TUdmin="-3" /isTUend="TRUE" CDS complement(3298384..3299919) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" /EC_number="5.4.2.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9830105, 10869096, 12682299, 19193632, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9830105, 10869096, 12682299, 19193632, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate mutase" /protein_id="NP_391271.1" /db_xref="EnsemblGenomes-Gn:BSU33910" /db_xref="EnsemblGenomes-Tr:CAB15396" /db_xref="GOA:P39773" /db_xref="InterPro:IPR005995" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR011258" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR036646" /db_xref="SubtiList:BG10898" /db_xref="UniProtKB/Swiss-Prot:P39773" /translation="MSKKPAALIILDGFGLRNETVGNAVALAKKPNFDRYWNQYPHQT LTASGEAVGLPEGQMGNSEVGHLNIGAGRIVYQSLTRVNVAIREGEFERNQTFLDAIS NAKENNKALHLFGLLSDGGVHSHINHLFALLKLAKKEGLTKVYIHGFLDGRDVGPQTA KTYINQLNDQIKEIGVGEIASISGRYYSMDRDKRWDRVEKAYRAMAYGEGPSYRSALD VVDDSYANGIYDEFVIPSVITKENGEPVAKIQDGDSVIFYNFRPDRAIQISNTFTNKD FRDFDRGENYPKNLYFVCLTHFSETVDGYVAFKPINLDNTVGEVLSQHGLKQLRIAET EKYPHVTFFMSGGREAEFPGEERILINSPKVATYDLKPEMSAYEVKDALVKEIEADKH DAIILNFANPDMVGHSGMVEPTIKAIEAVDECLGEVVDAILAKGGHAIITADHGNADI LITESGEPHTAHTTNPVPVIVTKEGITLREGGILGDLAPTLLDLLGVEKPKEMTGTSL IQK*" gene complement(3298384..3299919) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" CDS complement(3299912..3300673) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" /EC_number="5.3.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8021172, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="triose phosphate isomerase" /protein_id="NP_391272.1" /db_xref="EnsemblGenomes-Gn:BSU33920" /db_xref="EnsemblGenomes-Tr:CAB15397" /db_xref="GOA:P27876" /db_xref="InterPro:IPR000652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020861" /db_xref="InterPro:IPR022896" /db_xref="InterPro:IPR035990" /db_xref="SubtiList:BG10897" /db_xref="UniProtKB/Swiss-Prot:P27876" /translation="MRKPIIAGNWKMNKTLGEAVSFVEEVKSSIPAADKAEAVVCAPA LFLEKLASAVKGTDLKVGAQNMHFEESGAFTGEISPVALKDLGVDYCVIGHSERREMF AETDETVNKKAHAAFKHGIVPIICVGETLEEREAGKTNDLVADQVKKGLAGLSEEQVA ASVIAYEPIWAIGTGKSSTAKDANDVCAHIRKTVAESFSQEAADKLRIQYGGSVKPAN IKEYMAESDIDGALVGGASLEPQSFVQLLEEGQYE*" gene complement(3299912..3300673) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" CDS complement(3300704..3301888) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" /EC_number="2.7.2.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559176, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559176, 12682299, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate kinase" /protein_id="NP_391273.1" /db_xref="EnsemblGenomes-Gn:BSU33930" /db_xref="EnsemblGenomes-Tr:CAB15398" /db_xref="GOA:P40924" /db_xref="InterPro:IPR001576" /db_xref="InterPro:IPR015824" /db_xref="InterPro:IPR015911" /db_xref="InterPro:IPR036043" /db_xref="SubtiList:BG11062" /db_xref="UniProtKB/Swiss-Prot:P40924" /translation="MNKKTLKDIDVKGKVVFCRVDFNVPMKDGEVTDDTRIRAALPTI KHLADQGAKVLLASHLGRPKGEVVEELRLTPVAARLGELLGKEVKKADEAYGDAVKAQ ISEMKDGDVLVLENVRFYPGEEKNDPELAKAFAELADVYVNDAFGAAHRAHASTAGIA EHLPAVAGFLMEKELDVLGKAVSNPDRPFTAIIGGAKVKDKIGVIESLLDKVDNLIIG GGLAYTFVKALGYEVGKSLLEEDKIELAKSFMDRAKEKGVNFYMPEDVLVADDFSNDA NVKIVPISEIPSDLEAIDIGTKTRETYADVIKNSKLVVWNGPMGVFEIDLFAQGTKAV AEALAEAKDTYSVIGGGDSAAAVEKFGLADKMSHISTGGGASLEFMEGKELPGVAALN DK*" gene complement(3300704..3301888) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" S_feature complement(3301889..3302129) /Source="Nicolas_S_feature" /locus_tag="new_3481382_3481622_c" /HighExp="Lbstat, Lbtran, C90, LBGtran, LBGexp, G150, M40t45, LPhT, M0t45, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA, SigK" /TUshortPSig="0.979, 0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1300" upshifts complement(3302129) /Source="Nicolas_upshifts" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" S_feature complement(3302131..3302204) /Source="Nicolas_S_feature" /locus_tag="new_3481624_3481697_c" /HighExp="C90, LBGtran, Lbstat, LBGexp, Lbtran, G150, M40t45, Etha, ferm, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1301" promotor_-10 complement(3302143..3302162) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3302178..3302182) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3302205..3303212) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" /EC_number="1.2.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NAD-dependent, glycolytic)" /protein_id="NP_391274.1" /db_xref="EnsemblGenomes-Gn:BSU33940" /db_xref="EnsemblGenomes-Tr:CAB15399" /db_xref="GOA:P09124" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10827" /db_xref="UniProtKB/Swiss-Prot:P09124" /translation="MAVKVGINGFGRIGRNVFRAALNNPEVEVVAVNDLTDANMLAHL LQYDSVHGKLDAEVSVDGNNLVVNGKTIEVSAERDPAKLSWGKQGVEIVVESTGFFTK RADAAKHLEAGAKKVIISAPANEEDITIVMGVNEDKYDAANHDVISNASCTTNCLAPF AKVLNDKFGIKRGMMTTVHSYTNDQQILDLPHKDYRRARAAAENIIPTSTGAAKAVSL VLPELKGKLNGGAMRVPTPNVSLVDLVAELNQEVTAEEVNAALKEAAEGDLKGILGYS EEPLVSGDYNGNKNSSTIDALSTMVMEGSMVKVISWYDNESGYSNRVVDLAAYIAKKG L*" gene complement(3302205..3303212) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" promotor_-35 3303131..3303134 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3303151..3303153 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3303153 /Source="Nicolas_upshifts" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3303259..3304281) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489127, 12622823, 17142398, 17293407, 18052209, 18554327" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489127, 12622823, 17142398, 17293407, 18052209, 18554327; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of gapA" /protein_id="NP_391275.1" /db_xref="EnsemblGenomes-Gn:BSU33950" /db_xref="EnsemblGenomes-Tr:CAB15400" /db_xref="GOA:O32253" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OKG" /db_xref="PDB:3BXE" /db_xref="PDB:3BXF" /db_xref="PDB:3BXG" /db_xref="PDB:3BXH" /db_xref="SubtiList:BG14085" /db_xref="UniProtKB/Swiss-Prot:O32253" /translation="MNQLIQAQKKLLPDLLLVMQKRFEILQYIRLTEPIGRRSLSASL GISERVLRGEVQFLKEQNLVDIKTNGMTLTEEGYELLSVLEDTMKDVLGLTLLEKTLK ERLNLKDAIIVSGDSDQSPWVKKEMGRAAVACMKKRFSGKNIVAVTGGTTIEAVAEMM TPDSKNRELLFVPARGGLGEDVKNQANTICAHMAEKASGTYRLLFVPGQLSQGAYSSI IEEPSVKEVLNTIKSASMLVHGIGEAKTMAQRRNTPLEDLKKIDDNDAVTEAFGYYFN ADGEVVHKVHSVGMQLDDIDAIPDIIAVAGGSSKAEAIEAYFKKPRNTVLVTDEGAAK KLLRDE*" gene complement(3303259..3304281) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" upshifts complement(3303275) /Source="Nicolas_upshifts" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" promotor_-10 complement(3303283) /Source="Nicolas_upshift_promotors" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3303303..3303304) /Source="Nicolas_upshift_promotors" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3304282..3304393) /Source="Nicolas_S_feature" /locus_tag="new_3483775_3483886_c" /HighExp="LPhT, C90, LBGtran, Heat, BI, LBGexp, Lbstat, Sw, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1302" downshifts 3304319 /Source="Nicolas_upshifts" /id="D1765" /incds=0 /nref=3 /ntot=50 /MaxReadThrough="4.48989" /MaxDrop="5.24842" /score="-9.71393179" /energy="-11.8" /TU="NA" /idTUdmin="U2675" /TUdmin=1078 /isTUend="FALSE" promotor_-10 complement(3304374..3304393) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3304393) /Source="Nicolas_upshifts" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" S_feature complement(3304395..3304505) /Source="Nicolas_S_feature" /locus_tag="new_3483888_3483998_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, S3, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1303" promotor_-35 complement(3304407..3304414) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3304488..3304507) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-10" upshifts complement(3304503) /Source="Nicolas_upshifts" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" promotor_-35 complement(3304520..3304529) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-35" CDS complement(3304579..3305973) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9620981, 10417639, 15849754, 16850406, 20693325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620981, 10417639, 15849754, 16850406, 20693325; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arabinose-related compounds permease" /protein_id="NP_391276.1" /db_xref="EnsemblGenomes-Gn:BSU33960" /db_xref="EnsemblGenomes-Tr:CAB15401" /db_xref="GOA:P96710" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11907" /db_xref="UniProtKB/Swiss-Prot:P96710" /translation="MKNTPTQLEPNVPVTRSHSMGFVILISCAAGLGGLLYGYDTAVI SGAIGFLKDLYSLSPFMEGLVISSIMIGGVVGVGISGFLSDRFGRRKILMTAALLFAI SAIVSALSQDVSTLIIARIIGGLGIGMGSSLSVTYITEAAPPAIRGSLSSLYQLFTIL GISATYFINLAVQRSGTYEWGVHTGWRWMLAYGMVPSVIFFLVLLVVPESPRWLAKAG KTNEALKILTRINGETVAKEELKNIENSLKIEQMGSLSQLFKPGLRKALVIGILLALF NQVIGMNAITYYGPEIFKMMGFGQNAGFVTTCIVGVVEVIFTVIAVLLIDKVGRKKLM SIGSAFMAIFMILIGTSFYFELTSGIMMIVLILGFVAAFCVSVGPITWIMISEIFPNH LRARAAGIATIFLWGANWAIGQFVPMMIDSFGLAYTFWIFAVINILCFLFVVTICPET KNKSLEEIEKLWIK*" gene complement(3304579..3305973) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" downshifts complement(3304593) /Source="Nicolas_upshifts" /id="D1766" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="1.15614" /MaxDrop="3.28809" /score="1.06999853" /energy="-14.6" /TU="NA" /idTUdmin="U2679" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3306072..3306091) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3306086) /Source="Nicolas_upshifts" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" promotor_-35 complement(3306106..3306113) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3306113..3306120 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3306134..3306153 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3306140 /Source="Nicolas_upshifts" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" CDS 3306177..3307265 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the ara regulon (LacI family)" /protein_id="NP_391277.2" /db_xref="EnsemblGenomes-Gn:BSU33970" /db_xref="EnsemblGenomes-Tr:CAB15402" /db_xref="GOA:P96711" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR028082" /db_xref="InterPro:IPR033532" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3TB6" /db_xref="PDB:4EGY" /db_xref="PDB:4EGZ" /db_xref="PDB:4H0E" /db_xref="PDB:5D4R" /db_xref="PDB:5D4S" /db_xref="SubtiList:BG11913" /db_xref="UniProtKB/Swiss-Prot:P96711" /translation="MLPKYAQVKEEISSWINQGKILPDQKIPTENELMQQFGVSRHTI RKAIGDLVSQGLLYSVQGGGTFVASRSAKSALHSNKTIGVLTTYISDYIFPSIIRGIE SYLSEQGYSMLLTSTNNNPDNERRGLENLLSQHIDGLIVEPTKSALQTPNIGYYLNLE KNGIPFAMINASYAELAAPSFTLDDVKGGMMAAEHLLSLGHTHMMGIFKADDTQGVKR MNGFIQAHRERELFPSPDMIVTFTTEEKESKLLEKVKATLEKNSKHMPTAILCYNDEI ALKVIDMLREMDLKVPEDMSIVGYDDSHFAQISEVKLTSVKHPKSVLGKAAAKYVIDC LEHKKPKQEDVIFEPELIIRQSARKLNE*" gene 3306177..3307265 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" downshifts 3307245 /Source="Nicolas_upshifts" /id="D1767" /incds=0 /nref=202 /ntot=247 /MaxReadThrough="1.17419" /MaxDrop="4.76041" /score="20.2322165" /energy="-13.6" /TU="NA" /idTUdmin="U2680" /TUdmin=0 /isTUend="TRUE" CDS complement(3307314..3308324) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_391278.1" /db_xref="EnsemblGenomes-Gn:BSU33980" /db_xref="EnsemblGenomes-Tr:CAB15403" /db_xref="GOA:O32254" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG14086" /db_xref="UniProtKB/Swiss-Prot:O32254" /translation="MSNNQRKDTLLSVLNLSPVVQGGTIAESFRNSMDLARRAEEWGY HRYWLAEHHNIEGVASSATAVLIGHIAGGTKKIRVGSGGIMLPNHSSLVIAEQFGTLE TLYPGRIDLGLGRAPGTDQLTARALRRNINSGEDFPEQLEELRNYFKPSGNVRNQVRA IPGEGIDVPIWLLGSSGFSARLAGELGLPFAFAAHFSPANTVPALELYRNSFTPSDVL DEPYAMVGVTIIAADTNEKAQHLATSHYQRFLDLVRGTPNQLKPPVEDMDQIWSPYEK AMVNEQLSSTIVGGPEEVKAKLEDFVKTTQADEIMVNSETFEHADRMRSFEIIADVWK NR*" gene complement(3307314..3308324) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" downshifts complement(3307321) /Source="Nicolas_upshifts" /id="D1768" /incds=0 /nref=200 /ntot=252 /MaxReadThrough="1.53983" /MaxDrop="7.63266" /score="27.2032847" /energy="-14.2" /TU="NA" /idTUdmin="U2681" /TUdmin=0 /isTUend="TRUE" S_feature complement(3308325..3308402) /Source="Nicolas_S_feature" /locus_tag="new_3487818_3487895_c" /HighExp="dia5, dia15, Diami, H2O2, Salt, Paraq, G180, Etha, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1304" promotor_-10 complement(3308392..3308411) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3308402) /Source="Nicolas_upshifts" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" promotor_-35 complement(3308425..3308432) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3308481..3309359) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391279.1" /db_xref="EnsemblGenomes-Gn:BSU33990" /db_xref="EnsemblGenomes-Tr:CAB15404" /db_xref="GOA:O32255" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14087" /db_xref="UniProtKB/Swiss-Prot:O32255" /translation="MTITQLKVFVKIAETGSFTKAGQALNMTQPAVSHAISAIEAELD VKLIIRDRRNGLMLTDTGKQILVHIREVLKGIEKVEQVAAAEKGLELGTIHIGTFSTA SAYFMPKLISEFKQKYPKLELVLHEGTVNEVKEWLHTRMIDVGILLYPTEEMEYIHLK KDKMAVVLRDDHPLASHSAITLKDLDHEPMIVCDGGYESPFIDMFRQAGATLHPAFTV YNINTSISMIREGLGLAILSEMSMSGMPLPEHVVTRELDPQVYRDVQLAVPSLKEASL AAKLFIEMAKELFGAE*" gene complement(3308481..3309359) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" promotor_-35 3309017..3309023 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3309038..3309049 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3309049 /Source="Nicolas_upshifts" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 3309393..3309400 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3309406..3309425) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-10" upshifts complement(3309411) /Source="Nicolas_upshifts" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" promotor_-10 3309414..3309433 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3309416 /Source="Nicolas_upshifts" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" promotor_-35 complement(3309439..3309443) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-35" CDS 3309459..3310376 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10844694, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cysteine and O-acetylserine efflux permease" /protein_id="NP_391280.1" /db_xref="EnsemblGenomes-Gn:BSU34000" /db_xref="EnsemblGenomes-Tr:CAB15405" /db_xref="GOA:O32256" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG14088" /db_xref="UniProtKB/Swiss-Prot:O32256" /translation="MKQLPKTRTALLLAFLVIMWGVNWPLSKAALAYSPPLLFAGIRT LIGGLLLVIVALPRIHKLRLKETWPIYLVSALLNITLFYGLQTIGLNYLPAGLFSAIV FFQPVLMGVFSWLWLGESMFVMKVIGLILGFAGVAVISAAGFGGHISVIGVLLALGSA VSWALGTVYMKKTGSRVDSIWMVALQLTIGSVFLLISGFWTESFSAIQWTAPFITSLL FISVFVIALGWLVFFTLVGSGEASKVASYTFLIPLISIVASSIFLHEPLTLSLLAGLL LIVTSICLVNTKSKAQKAAAIGINEKAAQ*" gene 3309459..3310376 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" downshifts 3310365 /Source="Nicolas_upshifts" /id="D1769" /incds=0 /nref=6 /ntot=15 /MaxReadThrough="2.97475" /MaxDrop="3.548" /score="22.9557936" /energy="-19.2" /TU="NA" /idTUdmin="U2684" /TUdmin="-4" /isTUend="TRUE" CDS complement(3310417..3311760) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19258532, 25645558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative leucine permease" /protein_id="NP_391281.1" /db_xref="EnsemblGenomes-Gn:BSU34010" /db_xref="EnsemblGenomes-Tr:CAB15406" /db_xref="GOA:O32257" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG14089" /db_xref="UniProtKB/Swiss-Prot:O32257" /translation="MKNDNQTLKRTMTSRHIMMMALGGAIGAGLFKGSSSAIDVAGPS VIIAYLLGGIILLFIMQGLAEMAVRNRNARTFRDLVQQVLGNYAAYFLDWIYWKMWVL NIAAEAVVAAIFIQYWLPGCPIWVLALGISLIVTIVNLLSVKIFAETEYWLAMIKITV IIIFIILGLLLLFVSFGDHTASGFSNLTDHGGFFPHGGTGLITAMLVVIYSYGGTEII GVTLAETKNPEKVVPKAVRSTLTRIVAFYLLPFFIIVSLIPWNQVNSVPESPFVMVFK MVGIPGADHIMNAVILLAIISSMNSGLYGSSRILYTQASDGRLPKVFSKLSSKNVPMF AILMCTSSLYIGVLISLFAGSQTFNYLMGSLGYTVLFIWLIIGFAHLKSRKQQTETPA YYVKWFPYTTWFAIVALLAILIGVIMTTSIVITGITAAIYLLITVAYLVKGRKHQ*" gene complement(3310417..3311760) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" misc_RNA complement(3311829..3312064) /gene="tboX" /locus_tag="BSU_misc_RNA_56" /product="T-box riboswitch controlling synthesis of an amino acid transporter" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 18625071, 19258532; Product type n: RNA" /function="16.3: Control" gene complement(3311829..3312064) /gene="tboX" /locus_tag="BSU_misc_RNA_56" downshifts complement(3311963) /Source="Nicolas_upshifts" /id="D1770" /incds=1 /nref=1 /ntot=104 /MaxReadThrough="5.18182" /MaxDrop="2.29735" /score="33.4262209" /energy="-24.4" /TU="U2685,U2689" /idTUdmin="U2689" /TUdmin="-66" /isTUend="FALSE" S_feature complement(3312065..3312161) /Source="Nicolas_S_feature" /locus_tag="new_3491558_3491654_c" /HighExp="Cold, GM 120, C30, GM 90, C90, GM 15, GM 10, GM 25, HPh, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1305" CDS complement(3312162..3313196) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12177332; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative epimerase modification of peptidoglycan" /protein_id="NP_391282.1" /db_xref="EnsemblGenomes-Gn:BSU34020" /db_xref="EnsemblGenomes-Tr:CAB15407" /db_xref="GOA:O32258" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG14090" /db_xref="UniProtKB/Swiss-Prot:O32258" /translation="MKKWLIIAVSLAIAIVLFMYTKGEAKAAGMTVGYTTGDTASYNS LTKYHTYMNAIATDTFAFEKNGQIIGDAPTKQLTYAKKKKIKTWAVISNYNDAIYDFD GDLASRVMSNKTAKKRFTDQLITLAKKHSYYGINIDFEAVNPEDRAAYSNFIQYVSQA LNKKHIKTMVSVPAKSADDKNDDWSWPYDYAKIGKYADFVQVMTYDEHGIWGEPGSVA STNWIKSSLQFSVKKIKANKVIMGIPAYGYDWDVKDGSTSTIREWNELKSLIKKQKAK PAFNKKSGSMTFSYVDKKKHKHVVWYENEKTVQTKSHLAKQYKIAGVSVYALGNESES FWKAIRKGTK*" gene complement(3312162..3313196) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" promotor_-10 complement(3313218..3313236) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3313224) /Source="Nicolas_upshifts" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" promotor_-35 complement(3313249..3313256) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3313304..3314026) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22427629, 24196425, 24274019" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22427629, 24196425, 24274019; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase for L-lactate utilization" /protein_id="NP_391283.1" /db_xref="EnsemblGenomes-Gn:BSU34030" /db_xref="EnsemblGenomes-Tr:CAB15408" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR022823" /db_xref="SubtiList:BG14091" /db_xref="UniProtKB/Swiss-Prot:O32259" /translation="MTKGTIQNQESFLNRIASSLGRERRTGGVAVPEWAHQPQYKTLE GYSADDLVTVLKNHCVKIHTELIETDSTGLYDALREQVSRFSGGPVIIPKDPRFEEYG LKSLLTKDWPSEGTPVWEWDADKGEENIKKAEQANVGITFSEITLAESGTVVLFSSKD IGRSVSLLPTTYIAIVPKSSIVPRMTQASDIIRQNIANGVTVPSCINYITGPSNSADI EMDLVVGVHGPVKAAYILVSDR*" gene complement(3313304..3314026) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" downshifts complement(3313320) /Source="Nicolas_upshifts" /id="D1771" /incds=0 /nref=194 /ntot=266 /MaxReadThrough="4.5919" /MaxDrop="7.41457" /score="25.5917046" /energy="-15.7" /TU="U2689" /idTUdmin="U2689" /TUdmin="-1423" /isTUend="FALSE" CDS complement(3314026..3315465) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase linked to L-lactate utilization" /protein_id="NP_391284.1" /db_xref="EnsemblGenomes-Gn:BSU34040" /db_xref="EnsemblGenomes-Tr:CAB15409" /db_xref="GOA:O07021" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR004452" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR022825" /db_xref="InterPro:IPR024569" /db_xref="SubtiList:BG12448" /db_xref="UniProtKB/Swiss-Prot:O07021" /translation="MAMKIGTDAFKERVSQGIDNEFMRGAVSGAQERLRTRRLEAAEE LGNWEEWRSLSEEIRQHVLENLDFYLGQLAENVAKRGGHVYFAKTAEEASSYIRDVIQ KKNGKKIVKSKSMVTEEINLNEVLEKEGCEVVETDLGEYILQIDDHDPPSHIVAPALH KNKEQIRDVFKERLDYQHTEKPEELVMHARAILRKKFLEADIGITGCNFAIADTGSVS LVTNEGNGRLVSTLPKTQITVMGMERIVPSFSEFEVLVSMLTRSAVGQRLTSYITALT GPKLEGEVDGPEEFHLVIVDNGRSNILGTEFQSVLQCIRCAACINVCPVYRHVGGHSY GSIYSGPIGAVLSPLLGGYDDYKELPYASSLCAACSEACPVKIPLHELLLKHRQNIVE KEGRAPISEKLAMKAFGLGASSLSLYKMGSKWAPAAMTPFTEDEKISKGPGPLKNWTQ IRDFPAPHKSRFRDWFADRETSERTKEEQ*" gene complement(3314026..3315465) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" promotor_-35 3315013..3315016 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3315033 /Source="Nicolas_upshifts" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 3315034..3315038 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 3315187 /Source="Nicolas_upshifts" /id="D1772" /incds=1 /nref=1 /ntot=175 /MaxReadThrough="1.77859" /MaxDrop="3.31917" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2686" /TUdmin=0 /isTUend="TRUE" upshifts 3315341 /Source="Nicolas_upshifts" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 3315342..3315343 /Source="Nicolas_upshift_promotors" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3315492..3316208) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" /EC_number="1.8.98.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-sulfur oxidase subunit used in L-lactate utilization" /protein_id="NP_391285.1" /db_xref="EnsemblGenomes-Gn:BSU34050" /db_xref="EnsemblGenomes-Tr:CAB15410" /db_xref="GOA:O07020" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR022822" /db_xref="SubtiList:BG12447" /db_xref="UniProtKB/Swiss-Prot:O07020" /translation="MKVSLFVTCLVDMFQTNVGKATVELLERLGCEVDFPEGQICCGQ PAYNSGYVHDAKKAMKRMIETFQDSEYVVSPSGSCTTMFREYPHLFQDDPKWADKAKK LADKTYELTDFIVNVLGVEDVGATLHTKATLHTSCHMTRLLGVRKEPMKLLSHVKGLQ FTELPGKHNCCGFGGTFSVKMAQISEQMVDEKVECVEETGAEVLIGADCGCLMNIGGR LGRKDKNVKVMHIAEVLNSR*" gene complement(3315492..3316208) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" promotor_-35 3316112..3316119 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3316133..3316135 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3316133 /Source="Nicolas_upshifts" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 3316206 /Source="Nicolas_upshifts" /id="D1773" /incds=0 /nref=15 /ntot=169 /MaxReadThrough="1.96527" /MaxDrop="4.662" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2688" /TUdmin="-15" /isTUend="TRUE" S_feature complement(3316209..3316275) /Source="Nicolas_S_feature" /locus_tag="new_3495702_3495768_c" /HighExp="C90, M40t90, T3.0H, T4.0H, HiOs, T1.0H, T3.30H, T2.30H, Lbstat, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1306" promotor_-10 complement(3316272..3316291) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-10" upshifts complement(3316275) /Source="Nicolas_upshifts" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" promotor_-35 complement(3316306..3316313) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-35" CDS complement(3316383..3316985) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvfT]" /protein_id="NP_391286.1" /db_xref="EnsemblGenomes-Gn:BSU34060" /db_xref="EnsemblGenomes-Tr:CAB15411" /db_xref="GOA:O07019" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12446" /db_xref="UniProtKB/Swiss-Prot:O07019" /translation="MIRLFIAEDQRMLLGALGSLLDLEEDMTVIGQALNGEEALHAIL KLEPDVCIMDIEMPVRSGLNVAEELMKKGCVSKVIILTTFARPGYFERAVKAGAHGYL LKDGEIDDLADAIRKCVKGKRVFSPELTFNMMRDENPLTVREQEILRLAALGKTTKDI TLELYLSQGTVRNYISEIIQKLNAKNRTEAASIAEEKGWI*" gene complement(3316383..3316985) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" CDS complement(3317002..3318117) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YvfU]" /protein_id="NP_391287.2" /db_xref="EnsemblGenomes-Gn:BSU34070" /db_xref="EnsemblGenomes-Tr:CAB15412" /db_xref="GOA:Q795K2" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12445" /db_xref="UniProtKB/Swiss-Prot:Q795K2" /translation="MKKAISIFPKEFGFFPYIFLVYTIMPFLSLLKESGVKQGIGYGM LLLFVAAYRQLFCSVGKASFTYWLIVQMAVILMYSVFYNITYIYLGFFPANFVGYYKE KTNFNRAFCALIFILLFPCLYQFIANSVSLRELFSVLPFLVIMLISPFGIRSMFRRIE LEAKLAQANEQIKELSKREERVRIARDLHDTLGHTLSLLTLKSQLIQRLAASDPERTK LEAKEMETSSRSALKQVRELVSDMRTVTITEELVNIQHILRAGNITFQYEGADDFSVI SPVTQNIISMCMREAVTNIIKHSKATHCAITISQFADKMRIVIRDDGKGAPKEKMFGN GLWGMEERLMLIEGGLTVSDHNGTVVALTIPLIKKAE*" gene complement(3317002..3318117) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" CDS complement(3318121..3318858) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_391288.1" /db_xref="EnsemblGenomes-Gn:BSU34080" /db_xref="EnsemblGenomes-Tr:CAB15413" /db_xref="GOA:O07017" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12444" /db_xref="UniProtKB/Swiss-Prot:O07017" /translation="MNVLQKQSIAEMKRVLRNKYFVLWSLIMPIAFYYFFTNVVNTNV PDQRAWEAHYLMSMTVFSVMGSSIMTLGIRMVQERSQGWAAFIRLTPLPDHIYLSAQM IGQSVIHVLSITVIFLFGAIINDIALSPFEWMMSGLWILFGALPFLALGTLIGLMRKV ETAAGISNVLYMLLALGGGMWMPFEVMPDMMQSIGQWLPSYHFGSGAWELVRGGSPTW KNILILIAYMMLFMLLSKYIRRKQEAV*" gene complement(3318121..3318858) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" promotor_-10 complement(3318147..3318166) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-10" upshifts complement(3318161) /Source="Nicolas_upshifts" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" promotor_-35 complement(3318178..3318185) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-35" CDS complement(3318859..3319764) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_391289.1" /db_xref="EnsemblGenomes-Gn:BSU34090" /db_xref="EnsemblGenomes-Tr:CAB15414" /db_xref="GOA:O07016" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12443" /db_xref="UniProtKB/Swiss-Prot:O07016" /translation="MMKEAVTVSNVTKHFQRKTAVNNISFSIEKGEIAAILGPNGAGK TTVVSMILGLLKPSEGEIKLFNRVPDDQQVREKIGVMLQEVSVMPGLKVDEILELFRS YYPNPLSMKELVSLTALTKEDLKTRAEKLSGGQKRRLSFALALAGNPELLILDEPTVG MDTSSRHRFWQTIHGLSDQGKTIIFSTHYLQEADDAAQRILFFTEGQLVADGSPMQIR SRIQKQSVSFTLHSSESLERLSCHPEVERVIHEHERTIIQTSNTDKVLALIFQENIHA RDIRIEQATLDEAFRQLADGNREAM*" gene complement(3318859..3319764) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" promotor_-10 complement(3319784..3319802) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3319795) /Source="Nicolas_upshifts" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3319818..3319821) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3319973..3319980 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3319991..3320010 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3319998 /Source="Nicolas_upshifts" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" CDS 3320048..3320857 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11591687, 12620626, 15632289, 21980452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591687, 12620626, 15632289, 21980452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of RsbP phosphatase" /protein_id="NP_391290.1" /db_xref="EnsemblGenomes-Gn:BSU34100" /db_xref="EnsemblGenomes-Tr:CAB15415" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR031143" /db_xref="PDB:1WOM" /db_xref="PDB:1WPR" /db_xref="SubtiList:BG12442" /db_xref="UniProtKB/Swiss-Prot:O07015" /translation="MNEAILSRNHVKVKGSGKASIMFAPGFGCDQSVWNAVAPAFEED HRVILFDYVGSGHSDLRAYDLNRYQTLDGYAQDVLDVCEALDLKETVFVGHSVGALIG MLASIRRPELFSHLVMVGPSPCYLNDPPEYYGGFEEEQLLGLLEMMEKNYIGWATVFA ATVLNQPDRPEIKEELESRFCSTDPVIARQFAKAAFFSDHREDLSKVTVPSLILQCAD DIIAPATVGKYMHQHLPYSSLKQMEARGHCPHMSHPDETIQLIGDYLKAHV*" gene 3320048..3320857 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" CDS 3320893..3322104 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" /EC_number="3.1.3.3" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine protein-phosphatase" /protein_id="NP_391291.1" /db_xref="EnsemblGenomes-Gn:BSU34110" /db_xref="EnsemblGenomes-Tr:CAB15416" /db_xref="GOA:O07014" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG12441" /db_xref="UniProtKB/Swiss-Prot:O07014" /translation="MDKQLNDAPCGFLALSEEGSIIAANRTLIKILDYEPEQVIGQHM NMMLTIPAQLFCQLYFFPLLKLEHHIEEIYISLKARDGEEIPVLINAIARHDSGASVF DCVLIPMRKRNEYENELLIARNEAQEALLAKQKANAELEIALETLKAKQEELLEINKQ NQQFKLNTKRELELARKIQKNSLTEPIVNDQVQIDSYYNASSELSGDLYGYYQIDEHR YGIIILDVMGHGISSALITMSLHPLFQRQITQGLSPVKVMKELDRHLHSLFQNDEEAR HYCTAIYLEIDIARQRIDYVNAGHPPALWQDDSGTQHLLHATSPPIGMFEDLEFQSSS LSYTEDGRLLLYTDGVMDPTASCYLFDLLKDHPDSPIADLKEKILTSLQHQKEAHHKS DDECFILVDVK*" gene 3320893..3322104 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" downshifts 3322091 /Source="Nicolas_upshifts" /id="D1774" /incds=0 /nref=181 /ntot=246 /MaxReadThrough="0.90827" /MaxDrop="5.41923" /score="26.3528321" /energy="-17.8" /TU="NA" /idTUdmin="U2692" /TUdmin="-4" /isTUend="TRUE" CDS complement(3322158..3323447) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11682178, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,4-galactanase" /protein_id="NP_391292.2" /db_xref="EnsemblGenomes-Gn:BSU34120" /db_xref="EnsemblGenomes-Tr:CAB15417" /db_xref="GOA:O07013" /db_xref="InterPro:IPR011683" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12440" /db_xref="UniProtKB/Swiss-Prot:O07013" /translation="MKSKVKMFFAAAIVWSACSSTGYAAAIEKEKHVSELRAEDLFVK KVEGMNKDFIKGADVSSVIALENSGVTFYNTNGKRQDIFTTLKQAGVNYVRVRIWNHP YDSNGNGYGGGNNDVQKAIEIGKRATANGMKVLADFHYSDFWADPAKQKVPKAWANLS FEAKKAKLYEYTKQSLQKMIKEGVDIGMVQVGNETTGGFAGETDWTKMCQLFNEGSRA VRETNSNILVALHFTNPETAGRYSFIAETLSKNKVDYDVFASSYYPFWHGTLQNLTSV LKAVANTYGKKVMVAETSYTYTAEDGDGHGNTAPKSGQTLPYPISVQGQATAVRDVME AVANTGKAGLGVFYWEPAWIPVGPKTQIEKNKVLWETYGSGWASSYAAEYDPEDAGKW YGGSAVDNQALFDFNGHPLPSLQVFQYAESGHIPKKR*" gene complement(3322158..3323447) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" CDS complement(3323527..3325590) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" /EC_number="3.2.1.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="short chain beta-1,4-galacto-oligosaccharides beta-galactosidase (beta-galacto-pyranoside hydrolase)" /protein_id="NP_391293.1" /db_xref="EnsemblGenomes-Gn:BSU34130" /db_xref="EnsemblGenomes-Tr:CAB15418" /db_xref="GOA:O07012" /db_xref="InterPro:IPR003476" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013738" /db_xref="InterPro:IPR013739" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12439" /db_xref="UniProtKB/Swiss-Prot:O07012" /translation="MMSKLEKTHVTKAKFMLHGGDYNPDQWLDRPDILADDIKLMKLS HTNTFSVGIFAWSALEPEEGVYQFEWLDDIFERIHSIGGRVILATPSGARPAWLSQTY PEVLRVNASRVKQLHGGRHNHCLTSKVYREKTRHINRLLAERYGHHPALLMWHISNEY GGDCHCDLCQHAFREWLKSKYDNSLKTLNHAWWTPFWSHTFNDWSQIESPSPIGENGL HGLNLDWRRFVTDQTISFYENEIIPLKELTPDIPITTNFMADTPDLIPYQGLDYSKFA KHVDAISWDAYPVWHNDWESTADLAMKVGFINDLYRSLKQQPFLLMECTPSAVNWHNV NKAKRPGMNLLSSMQMIAHGSDSVLYFQYRKSRGSSEKLHGAVVDHDNSPKNRVFQEV AKVGETLERLSEVVGTKRPAQTAILYDWENHWALEDAQGFAKATKRYPQTLQQHYRTF WEHDIPVDVITKEQDFSPYKLLIVPMLYLISEDTVSRLKAFTADGGTLVMTYISGVVN EHDLTYTGGWHPDLQAIFGVEPLETDTLYPKDRNAVSYRSQIYEMKDYATVIDVKTAS VEAVYQEDFYARTPAVTSHEYQQGKAYFIGARLEDQFQRDFYEGLITDLSLSPVFPVR HGKGVSVQARQDQDNDYIFVMNFTEEKQLVTFDQSVKDIMTGDILSGDLTMEKYEVRI VVNTH*" gene complement(3323527..3325590) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" CDS complement(3325609..3326460) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17056685, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391294.1" /db_xref="EnsemblGenomes-Gn:BSU34140" /db_xref="EnsemblGenomes-Tr:CAB15419" /db_xref="GOA:O07011" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12438" /db_xref="UniProtKB/Swiss-Prot:O07011" /translation="MLADMKVRRYIRLLFSYLLLAFMAVIIVYPLLWTAGASFNPGNS LISTSIIPKHPTFDHYKELFAGKESLQYVQWYVNSMKISLFTMAGSLLCVTFTAYAFS RFRFKGRKYALTLFLLLQMIPQFSALIALFVLAQILGMINSHWLLILLYIGGLIPMNT YLMKGYMDSIPMDLDESAKIDGASSTRIFFQIILPLSKPMAAVVAMNGFTGPLGDFVL SSTILRTPESYTLPVGLFNLVNDVMGASYTTFAAGALLISIPVAVIFIMLQKNFVSGL TAGGTKG*" gene complement(3325609..3326460) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" CDS complement(3326464..3327720) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11160890, 15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 15849754, 16850406, 17056685, 27501980; Product type t : transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391295.1" /db_xref="EnsemblGenomes-Gn:BSU34150" /db_xref="EnsemblGenomes-Tr:CAB15420" /db_xref="GOA:O32261" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12437" /db_xref="UniProtKB/Swiss-Prot:O32261" /translation="MQHRQVALLLSIIPGLGQFYNKQWIKGIVFLFLGASFFAVFGDL LNMGFWGIFTLGTEVPRDNSVFLLAEGIIAVIVTCFGLAVYYVNLRDAFQSGKQRDEN KPLSSLKEQYQHIISEGYPYVVSGPSLFILIFAVIFPILFSFALAFTNYDLYHSPPAK LIDWVGFQTFANIFTVDIWRSTFFDVLAWTVVWTLAASTLQVTLGIFLAIIVNQKDLR FKRFFRTILILPWAVPGFVTILIFAGLFNDSFGAMNHDILAFFGIDPLPWMTDANWSR LALILMQGWLGFPYIFLVSTGVLQSIPDDLYEAATIDGASVFSKLRYITLPMVFIAMA PIIITQFTFNFNNFNIIYLFNGGGPAVTGSTAGGTDILVSWIYKLTMQSSQYSLAAAL TILLSVFVISIALWQFRQTKSFKEEA*" gene complement(3326464..3327720) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" CDS complement(3327760..3329025) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11682178, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="polygalactose / cyclodextrin-binding lipoprotein" /protein_id="NP_391296.1" /db_xref="EnsemblGenomes-Gn:BSU34160" /db_xref="EnsemblGenomes-Tr:CAB15421" /db_xref="GOA:O07009" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12436" /db_xref="UniProtKB/Swiss-Prot:O07009" /translation="MKMAKKCSVFMLCAAVSLSLAACGPKESSSAKSSSKGSELVVWE DKEKSNGIKDAVAAFEKEHDVKVKVVEKPYAKQIEDLRMDGPAGTGPDVLTMPGDQIG TAVTEGLLKELHVKKDVQSLYTDASIQSQMVDQKLYGLPKAVETTVLFYNKDLITEKE LPKTLEEWYDYSKKTADGSKFGFLALFDQIYYAESVMSGYGGYIFGKAKDGSYNPSDI GINNEGAVKGAALIQKFYKDGLFPAGIIGEQGINVLESLFTEGKAAAIISGPWNVEAF SNAGINYGITKLPKLENGKNMSSFIGVKSYNVSAFSKNEELAQELAVFLANEKNSKTR YEETKEVPAVKSLANDPAIMKSEAARAVTEQSRFSEPTPNIPEMNEIWTPADSALQTV ATGKADPKQALDQAAETAKGQIKAKHSGK*" gene complement(3327760..3329025) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" promotor_-10 complement(3329057..3329076) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3329079) /Source="Nicolas_upshifts" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" promotor_-35 complement(3329091..3329098) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3329166..3330158) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 10486575, 17056685, 27501980, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 10486575, 17056685, 27501980, 28617843; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the galactan degradation operon (GanR / beta-1,4-galactobiose)" /protein_id="NP_391297.1" /db_xref="EnsemblGenomes-Gn:BSU34170" /db_xref="EnsemblGenomes-Tr:CAB15422" /db_xref="GOA:O07008" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12435" /db_xref="UniProtKB/Swiss-Prot:O07008" /translation="MATIKDIAQEAGFSISTVSRVLNNDESLSVPDETREKIYEAAEK LNYRKKTVRPLVKHIAFLYWLTDKEELEDVYFKTMRLEVEKLAKAFNVDMTTYKIADG IESIPEHTEGFIAVGTFSDEELAFLRNLTENGVFIDSTPDPDHFDSVRPDLAQMTRKT VNILTEKGHKSIGFIGGTYKNPNTNQDEMDIREQTFRSYMREKAMLDERYIFCHRGFS VENGYRLMSAAIDTLGDQLPTAFMIAADPIAVGCLQALNEKGIAIPNRVSIVSINNIS FAKYVSPPLTTFHIDIHELCKNAVQLLLEQVQDKRRTVKTLYVGAELIVRKSMN*" gene complement(3329166..3330158) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" downshifts complement(3329200) /Source="Nicolas_upshifts" /id="D1775" /incds=0 /nref=2 /ntot=55 /MaxReadThrough="1.40325" /MaxDrop="2.80992" /score="14.7399792" /energy="-8.3" /TU="NA" /idTUdmin="U2694" /TUdmin=1111 /isTUend="FALSE" S_feature complement(3330288..3330337) /Source="Nicolas_S_feature" /locus_tag="new_3509781_3509830_c" /HighExp="Sw, BC, M0t90, M40t90, B60, Lbstat, Lbtran, S2, B36, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29208099999999998" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1307" downshifts complement(3330311) /Source="Nicolas_upshifts" /id="D1776" /incds=0 /nref=88 /ntot=240 /MaxReadThrough="1.88481" /MaxDrop="5.0699" /score="7.28170345" /energy="-13.7" /TU="NA" /idTUdmin="U2694" /TUdmin=0 /isTUend="TRUE" CDS complement(3330338..3330997) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18604637, 24196425, 25031425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18604637, 24196425, 25031425; Product type r: regulator" /codon_start=1 /transl_table=11 /product="L-lactate utilization global transcriptional regulator (GntR family)" /protein_id="NP_391298.2" /db_xref="EnsemblGenomes-Gn:BSU34180" /db_xref="EnsemblGenomes-Tr:CAB15423" /db_xref="GOA:O07007" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12434" /db_xref="UniProtKB/Swiss-Prot:O07007" /translation="MIKNGELKPGDKLDSVQALAESFQVSRSAVREALSALKAMGLVE MKQGEGTYLKEFELNQISQPLSAALLMKKEDVKQLLEVRKLLEIGVASLAAEKRTEAD LERIQDALKEMGSIEADGELGEKADFAFHLALADASQNELLKHLMNHVSSLLLETMRE TRKIWLFSKKTSVQRLYEEHERIYNAVAAGNGAQAEAAMLAHLTNVEDVLSGYFEENV Q*" gene complement(3330338..3330997) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" S_feature complement(3330998..3331103) /Source="Nicolas_S_feature" /locus_tag="new_3510491_3510596_c" /HighExp="M0t90, Lbstat, BC, M40t90, Lbtran, Sw, S2, B60, ferm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69672000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1308" promotor_-10 complement(3331095..3331114) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3331104) /Source="Nicolas_upshifts" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" promotor_-35 complement(3331129..3331132) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3331156..3331163 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3331178..3331197 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3331178 /Source="Nicolas_upshifts" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" S_feature 3331181..3331286 /Source="Nicolas_S_feature" /locus_tag="new_3510674_3510779" /HighExp="T1.30H, S1, T1.0H, M40t90, T2.0H, M0t90, T3.0H, T2.30H, T0.30H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1309" promotor_-10 complement(3331187..3331204) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3331191) /Source="Nicolas_upshifts" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3331212..3331218) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3331287..3332978 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25031425; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_391299.1" /db_xref="EnsemblGenomes-Gn:BSU34190" /db_xref="EnsemblGenomes-Tr:CAB15424" /db_xref="GOA:P71067" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG11875" /db_xref="UniProtKB/Swiss-Prot:P71067" /translation="MQWTQAYTPIGGNLLLSALAALVPIIFFFWALAIKRMKGYTAGL ATLGIALIIAVLVYRMPAEKALMSATQGAVYGLLPIGWIIVTSVFLYKITVKTGQFDI IRSSVLSITDDRRLQALLIAFSFGAFLEGAAGFGAPVAISAALLVGLGFNPLYAAGIC LIANTAPVAFGAIGIPITAVEGPTGIPAMEISQMVGRQLPFLSVFIPLYLIIIMSGFR KALEIWPAILVSGVSFAVVQYLSSNFLGPELPDVLSALVSMAALAVFLKWWKPKTTFR FAGEQESAASIETARTNPAAPAYRGGQIFKAWSPFLLLTAMISVWGIPSVKSALTGHY EGSAVFLKWLNAVGEKLTFSPGVPFLNNQIVNADGTPIEAVYKLEVLGSAGTAILIAA VLSKFITAISWKDWGTVFKETVQELKLPILTIASVVGFAYVTNSSGMSTTLGMTLALT GSMFTFFSPVLGWLGVFITGSDTSANLLFGNLQKVTALSVGMDPVLSVAANSSGGVTG KMISPQSIAVACAAVGLAGKESDLFRFTIKHSLFLLLLVCIITFLQHHVFSWMIP*" gene 3331287..3332978 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" downshifts 3332963 /Source="Nicolas_upshifts" /id="D1777" /incds=0 /nref=153 /ntot=245 /MaxReadThrough="4.82757" /MaxDrop="5.44233" /score="20.8815301" /energy="-11.7" /TU="NA" /idTUdmin="U2695" /TUdmin=0 /isTUend="TRUE" CDS complement(3333005..3334315) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11274109, 12533460, 12634342, 16166551, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 12533460, 12634342, 16166551, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-54 factor (sigma-L)" /protein_id="NP_391300.1" /db_xref="EnsemblGenomes-Gn:BSU34200" /db_xref="EnsemblGenomes-Tr:CAB15425" /db_xref="GOA:P24219" /db_xref="InterPro:IPR000394" /db_xref="InterPro:IPR007046" /db_xref="InterPro:IPR007634" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10748" /db_xref="UniProtKB/Swiss-Prot:P24219" /translation="MDMKLQQVQVLKPQLTQELRQAITLLGYHSAELAEYIDELSLEN PLIERKETDTPPLSYHKTNKNRMNAQEAGLQLSNPQKTLQDALKQQSLDMNLTNTEKK IFNYLIHSLDSNGYLEEDIEEAARRLSVSAKEAEAVLAKLQSLEPAGIGARSLQECIL LQLQRLPNRNEQAEMLVSAHFDAFAQKKWKTLSVETGIPLHTIQDISDDIAALHPRPG LLFARPEQDVYIEPDIFITVKNGHIAAELNTRSFPEIDLHPQYRTLLSSGSCQDTVSY LSAKYQEWRWLSRALRQRKQTITRIINELITRQKDFFLKGRSAMKPLTLREVADCLSL HESTVSRAIKGKTIQTPYGLFEMKLFFSAKAEASGDGDASNYAVKTHLENLINQEDKT KPLSDQKLVDLLYEQHGIQISRRTVAKYRDQMNIPSSAARKRYK*" gene complement(3333005..3334315) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" S_feature 3333008..3334078 /Source="Nicolas_S_feature" /locus_tag="new_3512501_3513571" /HighExp="M9-stat, T1.30H, S1, Sw, T1.0H, T2.0H, T0.30H, G/S, T3.30H, T2.30H" /AntisenseName="sigL" /AntisenseCor="0.63927172079726402" /AntisenseRegPval="-31.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1310" downshifts complement(3333017) /Source="Nicolas_upshifts" /id="D1778" /incds=0 /nref=62 /ntot=219 /MaxReadThrough="2.33779" /MaxDrop="5.56948" /score="28.2409666" /energy="-11.7" /TU="NA" /idTUdmin="U2698" /TUdmin=0 /isTUend="TRUE" misc_feature 3334135..3334154 /Source="Nicolas_upshift_promotors" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3334135..3334393 /Source="Nicolas_S_feature" /locus_tag="new_3513628_3513886" /HighExp="LBGstat, LBGexp, G180, Paraq, H2O2, LBGtran, Oxctl, Lbexp, dia0, HPh" /AntisenseName="sigL" /AntisenseCor="-0.50245218771496702" /AntisenseRegPval="-17.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1311" upshifts 3334135 /Source="Nicolas_upshifts" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" promotor_-10 complement(3334329..3334348) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3334344) /Source="Nicolas_upshifts" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" promotor_-35 complement(3334363..3334366) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3334394..3334612 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391301.1" /db_xref="EnsemblGenomes-Gn:BSU34210" /db_xref="EnsemblGenomes-Tr:CAB15426" /db_xref="InterPro:IPR018590" /db_xref="PDB:2GSV" /db_xref="PDB:2JS1" /db_xref="SubtiList:BG11876" /db_xref="UniProtKB/Swiss-Prot:P71066" /translation="MSELFSVPYFIENLKQHIEMNQSEDKIHAMNSYYRSVVSTLVQD QLTKNAVVLKRIQHLDEAYNKVKRGESK*" gene 3334394..3334612 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" downshifts 3334591 /Source="Nicolas_upshifts" /id="D1779" /incds=0 /nref=53 /ntot=250 /MaxReadThrough="3.27525" /MaxDrop="4.21929" /score="-0.306638574" /energy="-13.4" /TU="U2697" /idTUdmin="U2697" /TUdmin="-418" /isTUend="FALSE" CDS complement(3334622..3335590) /gene="epsO" /locus_tag="BSU_34220" /old_locus_tag="BSU34220" /EC_number="2.-.-.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1097084, 115661000, 20720312, 23378512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvyl transferase for matrix biofilm formation" /protein_id="NP_391302.1" /db_xref="EnsemblGenomes-Gn:BSU34220" /db_xref="EnsemblGenomes-Tr:CAB15427" /db_xref="GOA:P71065" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11874" /db_xref="UniProtKB/Swiss-Prot:P71065" /translation="MDSKHSMISLKQKLSGLLDVIPKQSEIIYADYPLYGNVGDLFIM KGTEAFFKEHGIRVRKRWNPDNFPIGRKLDPNLIIVCQGGGNFGDLYPYYQGFREKIV QTYPNHKIVILPQSIYFQNKDNLKRTAEIFSKHANLHIMTREKASYATAQAYFTTNHI QLLPDMAHQLFPVIPTQQPSNQKLRFIRTDHEANQALQEHAEAESYDWRTVLSASDRR TIAFLQTLNVLNKKAGNPLPIAYIWEKYSDYIVQKAIRFFSRYESVETSRLHGHILSS LLQKENTVIDNSYGKNANYFHTWMEGVPSTRLIQHASKKENLPAHM*" gene complement(3334622..3335590) /gene="epsO" /locus_tag="BSU_34220" /old_locus_tag="BSU34220" CDS complement(3335569..3336735) /gene="epsN" /locus_tag="BSU_34230" /old_locus_tag="BSU34230" /EC_number="2.6.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15661000, 20720312, 23378512, 27084765, 27897378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminotransferase involved in biofilm matrix formation" /protein_id="NP_391303.2" /db_xref="EnsemblGenomes-Gn:BSU34230" /db_xref="EnsemblGenomes-Tr:CAB15428" /db_xref="GOA:Q795J3" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11873" /db_xref="UniProtKB/Swiss-Prot:Q795J3" /translation="MHKKIYLSPPHMSGREQHYISEAFRSNWIAPLGPLVNSFEEQLA ERVGVKAAAAVGSGTAAIHLALRLLEVKEGDSVFCQSFTFVATANPILYEKAVPVFID SEPDTWNMSPTALERALEEAKRNGTLPKAVIAVNLYGQSAKMDEIVSLCDAYGVPVIE DAAESLGTVYKGKQSGTFGRFGIFSFNGNKIITTSGGGMLVSNDEAAIEKARFLASQA REPAVHYQHSEIGHNYRLSNILAGVGIAQLEVLDERVEKRRTIFTRYKNALGHLDGVR FMPEYAAGVSNRWLTTLTLDNGLSPYDIVQRLAEENIEARPLWKPLHTQPLFDPALFY SHEDTGSVCEDLFKRGICLPSGSNMTEDEQGRVIEVLLHLFHTVEVKKWTASIR*" gene complement(3335569..3336735) /gene="epsN" /locus_tag="BSU_34230" /old_locus_tag="BSU34230" CDS complement(3336740..3337390) /gene="epsM" /locus_tag="BSU_34240" /old_locus_tag="BSU34240" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15661000, 27897378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative O-acetyltransferase involved in biofilmmatrix formation" /protein_id="NP_391304.1" /db_xref="EnsemblGenomes-Gn:BSU34240" /db_xref="EnsemblGenomes-Tr:CAB15429" /db_xref="GOA:P71063" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR020019" /db_xref="SubtiList:BG11872" /db_xref="UniProtKB/Swiss-Prot:P71063" /translation="MKNVAIVGDGGHGKVIRELINARSDTRLAAVLDDKFKTFEGGKE WYTGPPKAVTELRRLIPDVLFLIAVGNNSVRKQLAERLGLGKDDFITLIHPSAIVSKS AVIGEGTVIMAGAIIQADARIGAHCIINTGAVAEHDNQISDYVHLSPRATLSGAVSVQ EGAHVGTGASVIPQIIIGAWSIVGAGSAVIRSIPDRVTAAGAPARIISSIQTSNKG*" gene complement(3336740..3337390) /gene="epsM" /locus_tag="BSU_34240" /old_locus_tag="BSU34240" CDS complement(3337387..3337995) /gene="epsL" /locus_tag="BSU_34250" /old_locus_tag="BSU34250" /EC_number="2.7.-.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 15661000, 23378512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase involved in extracellular matrix synthesis" /protein_id="NP_391305.1" /db_xref="EnsemblGenomes-Gn:BSU34250" /db_xref="EnsemblGenomes-Tr:CAB15430" /db_xref="GOA:P71062" /db_xref="InterPro:IPR003362" /db_xref="SubtiList:BG11871" /db_xref="UniProtKB/Swiss-Prot:P71062" /translation="MILKRLFDLTAAIFLLCCTSVIILFTIAVVRLKIGSPVFFKQVR PGLHGKPFTLYKFRTMTDERDSKGNLLPDEVRLTKTGRLIRKLSIDELPQLLNVLKGD LSLVGPRPLLMDYLPLYTEKQARRHEVKPGITGWAQINGRNAISWEKKFELDVWYVDN WSFFLDLKILCLTVRKVLVSEGIQQTNHVTAERFTGSGDVSS*" gene complement(3337387..3337995) /gene="epsL" /locus_tag="BSU_34250" /old_locus_tag="BSU34250" CDS complement(3337992..3339509) /gene="epsK" /locus_tag="BSU_34265" /old_locus_tag="BSU34265" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 15661000, 15849754, 16850406, 26078454, 27897378; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative extracellular matrix component exporter; putative cyclic di-GMP receptor" /protein_id="YP_003097789.1" /db_xref="EnsemblGenomes-Gn:BSU34265" /db_xref="EnsemblGenomes-Tr:CAX52695" /db_xref="GOA:P71060" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR029303" /db_xref="UniProtKB/Swiss-Prot:P71060" /translation="MKFTINFSANLTAFLLSVFLSVWMTPFIVKTLGVEAFGFVHLTQ NVINYFSVITVALSSVVVRFFSVAAHRGEREKANAYISNYLAASVLISLLLLLPLAGS AFFIDRVMNVPQALLADVRLSILIGSVLFILTFLMAGFGAAPFYANRLYITSSIQAVQ MLIRVLSVLLLFACFAPKIWQIQLAALAGAVIASVLSFYFFKKLIPWFSFRMKDLSFR TSKELFQAGAWSSVNQIGVLLFLQIDLLTANLMLGASASGKYAAIIQFPLLLRSLAGT VASLFAPIMTSYYSKGDMEGLMNYANKAVRLNGLLLALPAALLGGLAGPFLTIWLGPS FSTIAPLLFIHAGYLVVSLAFMPLFYIWTAFNQQKTPAIVTLLLGAVNVVLAVTLSGP AHLGLYGITLAGAISLILKNAIFTPLYVSRITGYKKHVFLKGIIGPLSAAVFAWTVCK AIQFIVKIDSWPSLIATGVTVSFCYAVFAFMLVCTKEERQLVLKRFRKTKGAVNL*" gene complement(3337992..3339509) /gene="epsK" /locus_tag="BSU_34265" /old_locus_tag="BSU34265" CDS complement(3339506..3340540) /gene="epsJ" /locus_tag="BSU_34280" /old_locus_tag="BSU34280" /EC_number="2.4.-.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15661000, 20720312, 26078454, 27897378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase involved in biofilm matrix formation" /protein_id="NP_391308.1" /db_xref="EnsemblGenomes-Gn:BSU34280" /db_xref="EnsemblGenomes-Tr:CAB15433" /db_xref="GOA:P71059" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11868" /db_xref="UniProtKB/Swiss-Prot:P71059" /translation="MIPLVSIIVPMYNVEPFIEECIDSLLRQTLSDIEIILVNDGTPD RSGEIAEDYAKRDARIRVIHQANGGLSSARNTGIKAARGTYIGFVDGDDYVSSAMFQR LTEEAEQNQLDIVGCGFYKQSSDRRTYVPPQLEANRVLTKPEMTEQLKHAHETRFIWY VWRYLYRRELFERANLLFDEDIRFAEDSPFNLSAFREAERVKMLDEGLYIYRENPNSL TEIPYKPAMDEHLQKQYQAKIAFYNHYGLAGACKEDLNVYICRHQLPMLLANACASPN SPKDIKKKIRQILSYDMVRQAVRHTPFQHEKLLRGERLVLALCKWRLTFLIKLFFEQR GTMKGSAKQA*" gene complement(3339506..3340540) /gene="epsJ" /locus_tag="BSU_34280" /old_locus_tag="BSU34280" CDS complement(3340537..3341613) /gene="epsI" /locus_tag="BSU_34290" /old_locus_tag="BSU34290" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15173185, 15661000, 20720312, 26078454; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polysaccharide pyruvyl transferase involved in biofilm matrix formation" /protein_id="NP_391309.1" /db_xref="EnsemblGenomes-Gn:BSU34290" /db_xref="EnsemblGenomes-Tr:CAB15434" /db_xref="GOA:P71058" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11867" /db_xref="UniProtKB/Swiss-Prot:P71058" /translation="MSLQSLKINFAEWLLLKVKYPSQYWLGAADQPVKAAAHQKKIIL TLLPSHDNLGDHAIAYASKAFLEQEYPDFDIVEVDMKDIYKSAKSLIRSRHPEDMVFI IGGGNMGDLYRYEEWTRRFIIKTFHDYRVVQLPATAHFSDTKKGRKELKRAQKIYNAH PGLLLMARDETTYQFMKQHFQEKTILKQPDMVLYLDRSKAPAEREGVYMCLREDQESV LQEEQRNRVKAALCEEFGEIKSFTTTIGRRVSRDTREHELEALWSKLQSAEAVVTDRL HGMIFCALTGTPCVVIRSFDHKVMEGYQWLKDIPFMKLIEHPEPERVTAAVNELLTKE TSRAGFPRDVYFKGLRDKISGEAQ*" gene complement(3340537..3341613) /gene="epsI" /locus_tag="BSU_34290" /old_locus_tag="BSU34290" CDS complement(3341618..3342652) /gene="epsH" /locus_tag="BSU_34300" /old_locus_tag="BSU34300" /EC_number="2.-.-.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15083514, 15661000; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in biofilmformation" /protein_id="NP_391310.1" /db_xref="EnsemblGenomes-Gn:BSU34300" /db_xref="EnsemblGenomes-Tr:CAB15435" /db_xref="GOA:P71057" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11866" /db_xref="UniProtKB/Swiss-Prot:P71057" /translation="METPAVSLLVAVYNTETYIRTCLESLRNQTMDNIEIIIVNDGSA DASPDIAEEYAKMDNRFKVIHQENQGLGAVRNKGIEAARGEFIAFIDSDDWIEPDYCE QMLRTAGDETDLVICNYAAEFEDTGKTMDSDIAQTYQDQPKEHYIKALFEGKVRGFSW NKLYRRSMIEAHRLSFPLRGELEHVEDQFFSFRAHFFARSVSYVKTPLYHYRIHLSSI VQRYQKKLFESGLALYETNAAFLQENNKLEEYRKELDTFIVLHSSICMLNEWKTSGSR RLFEKLRNVGVICADPVFQESLSKTGTAPFDAKRSCLLLMAKYRMIPFVAMASAVYQR VIEYKMRNRG*" gene complement(3341618..3342652) /gene="epsH" /locus_tag="BSU_34300" /old_locus_tag="BSU34300" CDS complement(3342677..3343780) /gene="epsG" /locus_tag="BSU_34310" /old_locus_tag="BSU34310" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15175311, 15661000, 15849754, 16850406, 22451411" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 15661000, 15849754, 16850406, 22451411; Product type f: factor" /codon_start=1 /transl_table=11 /product="biofilm extracellular matrix formation chain-length determining factor" /protein_id="NP_391311.1" /db_xref="EnsemblGenomes-Gn:BSU34310" /db_xref="EnsemblGenomes-Tr:CAB15436" /db_xref="GOA:P71056" /db_xref="SubtiList:BG11865" /db_xref="UniProtKB/Swiss-Prot:P71056" /translation="MIVYAVNMGIVFIWSWFAKMCGGRDDSLATGYRPNKLLIWIPLA SLVLVSGLRYRVGTDFQTYTLLYELAGDYQNVWQIFGFGTAKTATDPGFTALLWLMNF ITEDPQIMYFTVAVVTYSFIMKTLADYGRPFELSVFLFLGTFHYYASFNGIRQYMVAA VLFWAIRYIISGNWKRYFLIVLVSSLFHSSALIMIPVYFIVRRKAWSPAIFGLSALFL GMTFLYQKFISVFVVVLENSSYSHYEKWLMTNTNGMNVIKIAVLVLPLFLAFCYKERL RSLWPQIDIVVNLCLLGFLFGLLATKDVIFARFNIYFGLYQMILVPYFVRIFDEKSNA LIYIAIVVCYFLYSYLLMPVDSSVLPYRTIFSR*" gene complement(3342677..3343780) /gene="epsG" /locus_tag="BSU_34310" /old_locus_tag="BSU34310" CDS complement(3343777..3344931) /gene="epsF" /locus_tag="BSU_34320" /old_locus_tag="BSU34320" /EC_number="2.-.-.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 15661000, 22451411; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in matrix formation (chain-length determination)" /protein_id="NP_391312.1" /db_xref="EnsemblGenomes-Gn:BSU34320" /db_xref="EnsemblGenomes-Tr:CAB15437" /db_xref="GOA:P71055" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11864" /db_xref="UniProtKB/Swiss-Prot:P71055" /translation="MNSSQKRVLHVLSGMNRGGAETMVMNLYRKMDKSKVQFDFLTYR NDPCAYDEEILSLGGRLFYVPSIGQSNPLTFVRNVRNAIKENGPFSAVHAHTDFQTGF IALAARLAGVPVRVCHSHNTSWKTGFNWKDRLQLLVFRRLILANATALCACGEDAGRF LFGQSNMERERVHLLPNGIDLELFAPNGQAADEEKAARGIAADRLIIGHVARFHEVKN HAFLLKLAAHLKERGIRFQLVLAGDGPLCGEIEEEARQQNLLSDVLFLGTEERIHELM RTFDVFVMPSLYEGLPVVLVEAQASGLPCIISDSITEKVDAGLGLVTRLSLSEPISVW AETIARAAAAGRPKREFIKETLAQLGYDAQQNVGALLNVYNISTEKDHNR*" gene complement(3343777..3344931) /gene="epsF" /locus_tag="BSU_34320" /old_locus_tag="BSU34320" CDS complement(3344924..3345760) /gene="epsE" /locus_tag="BSU_34330" /old_locus_tag="BSU34330" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15175311, 15661000, 21170308, 22720735, 23480406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 15661000, 21170308, 22720735, 23480406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional flagellar clutch and glycosyltransferase acting during biofilm formation" /protein_id="NP_391313.2" /db_xref="EnsemblGenomes-Gn:BSU34330" /db_xref="EnsemblGenomes-Tr:CAB15438" /db_xref="GOA:P71054" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11863" /db_xref="UniProtKB/Swiss-Prot:P71054" /translation="MNSGPKVSVIMGIYNCERTLAESIESILSQSYKNWELILCDDAS TDGTLRIAKQYAAHYSDRIKLIQNKTNKRLAASLNHCLSHATGDYIARQDGDDLSFPR RLEKQVAFLEKHRHYQVVGTGMLVFDEFGVRGARILPSVPEPGIMAKGTPFCHGTIMM RASAYRTLKGYRSVRRTRRMEDIDLWLRFFEEGFRGYNLQEALYKVREDSDAFKRRSF TYSIDNAILVYQACRRLKLPLSDYIYIAKPLIRAFMPAAVMNRYHKKRVMNQKEGLVK HE*" gene complement(3344924..3345760) /gene="epsE" /locus_tag="BSU_34330" /old_locus_tag="BSU34330" CDS complement(3345757..3346902) /gene="epsD" /locus_tag="BSU_34340" /old_locus_tag="BSU34340" /EC_number="2.4.-.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 15661000, 23378512, 26299781; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative extracellular matrix glycosyltransferase" /protein_id="NP_391314.1" /db_xref="EnsemblGenomes-Gn:BSU34340" /db_xref="EnsemblGenomes-Tr:CAB15439" /db_xref="GOA:P71053" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11862" /db_xref="UniProtKB/Swiss-Prot:P71053" /translation="MTKKILFCATVDYHFKAFHLPYFKWFKQMGWEVHVAANGQTKLP YVDEKFSIPIRRSPFDPQNLAVYRQLKKVIDTYEYDIVHCHTPVGGVLARLAARQARR HGTKVLYTAHGFHFCKGAPMKNWLLYYPVEKWLSAYTDCLITINEEDYIRAKGLQRPG GRTQKIHGIGVNTERFRPVSPIEQQRLREKHGFREDDFILVYPAELNLNKNQKQLIEA AALLKEKIPSLRLVFAGEGAMEHTYQTLAEKLGASAHVCFYGFCSDIHELIQLADVSV ASSIREGLGMNVLEGMAAEQPAIATDNRGHREIIRDGENGFLIKIGDSAAFARRIEQL YHKPELCRKLGQEGRKTALRFSEARTVEEMADIYSAYMDMDTKEKSV*" gene complement(3345757..3346902) /gene="epsD" /locus_tag="BSU_34340" /old_locus_tag="BSU34340" CDS complement(3346914..3348710) /gene="epsC" /locus_tag="BSU_34350" /old_locus_tag="BSU34350" /EC_number="5.1.3.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15661000, 23378512, 27655338; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-sugar epimerase involved in biofilmmatrix formation" /protein_id="NP_391315.1" /db_xref="EnsemblGenomes-Gn:BSU34350" /db_xref="EnsemblGenomes-Tr:CAB15440" /db_xref="GOA:P71052" /db_xref="InterPro:IPR003869" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11861" /db_xref="UniProtKB/Swiss-Prot:P71052" /translation="MIIALDTYLVLNSVIAGYQFLKDSYQFYDSGALLLTAVSLLLSY HVCAFLFNQYKQVWTYTGLGELIVLLKGITLSAAVTGVIQYAVYHTMFFRLLTACWVL QLLSIGGTRILSRVLNESIRKKRCASSRALIIGAGSGGTLMVRQLLSKDEPDIIPVAF IDDDQTKHKLEIMGLPVIGGKESIMPAVQKLKINYIIIAIPSLRTHELQVLYKECVRT GVSIKIMPHFDEMLLGTRTAGQIRDVKAEDLLGRKPVTLDTSEISNRIKGKTVLVTGA GGSIGSEICRQISAFQPKEIILLGHGENSIHSIYTELNGRFGKHIVFHTEIADVQDRD KMFTLMKKYEPHVVYHAAAHKHVPLMEHNPEEAVKNNIIGTKNVAEAADMSGTETFVL ISSDKAVNPANVMGATKRFAEMIIMNLGKVSRTKFVAVRFGNVLGSRGSVIPIFKKQI EKGGPVTVTHPAMTRYFMTIPEASRLVIQAGALAKGRQIFVLDMGEPVKIVDLAKNLI HLSGYTTEQVPIEFTGIRPGEKMYEELLNKNEVHAEQIFPKIHIGKAVDGDWPVLMRF IEDFHELPEADLRARLFAAINTSEEMTAASVH*" gene complement(3346914..3348710) /gene="epsC" /locus_tag="BSU_34350" /old_locus_tag="BSU34350" S_feature complement(3348711..3348770) /Source="Nicolas_S_feature" /locus_tag="new_3528204_3528263_c" /HighExp="LoTm, G/S, M9-tran, BMM, MG 150, S3, S2, S4, aero, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.79" /TUlongSig="NA" /TUlongPSig="NA" /label="S1312" promotor_-10 complement(3348744..3348762) /Source="Nicolas_upshift_promotors" /id="U2699" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.79020979020979" /psig="0.79020979020979" /xcortree=2767 /SigmaFactorBS="atacataggacgtattgtcggtttagctgctgccgatttttt ggagagACGAAAAccgccgcagctaaACCGATAAAAGAATTAGGGgggaaaaggttga g" /listShort="S1312, epsC, epsD, epsE, epsF, epsG, epsH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3348770) /Source="Nicolas_upshifts" /id="U2699" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.79020979020979" /psig="0.79020979020979" /xcortree=2767 /SigmaFactorBS="atacataggacgtattgtcggtttagctgctgccgatttttt ggagagACGAAAAccgccgcagctaaACCGATAAAAGAATTAGGGgggaaaaggttga g" /listShort="S1312, epsC, epsD, epsE, epsF, epsG, epsH" /GFF_Attribute="listLong" promotor_-35 complement(3348776..3348782) /Source="Nicolas_upshift_promotors" /id="U2699" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.79020979020979" /psig="0.79020979020979" /xcortree=2767 /SigmaFactorBS="atacataggacgtattgtcggtttagctgctgccgatttttt ggagagACGAAAAccgccgcagctaaACCGATAAAAGAATTAGGGgggaaaaggttga g" /listShort="S1312, epsC, epsD, epsE, epsF, epsG, epsH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3348969..3349652) /gene="epsB" /locus_tag="BSU_34360" /old_locus_tag="BSU34360" /EC_number="2.7.10.2" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15661000, 15741737, 24493247, 26283769, 28950882" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15661000, 15741737, 24493247, 26283769, 28950882; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein tyrosine kinase involved in biofilm matrix formation" /protein_id="NP_391316.1" /db_xref="EnsemblGenomes-Gn:BSU34360" /db_xref="EnsemblGenomes-Tr:CAB15441" /db_xref="GOA:P71051" /db_xref="InterPro:IPR005702" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11860" /db_xref="UniProtKB/Swiss-Prot:P71051" /translation="MIFRKKKARRGLAQISVLHNKSVVAEQYRTIRTNIEFSSVQTNL RSILVTSSVPGEGKSFSAANLAAVFAQQQEKKVLLVDADLRKPTINQTFQVDNVTGLT NVLVGNASLSETVQKTPIDNLYVLTSGPTPPNPAELLSSKAMGDLISEIYEQFSLVIF DSPPLLAVADAQILANQTDGSVLVVLSGKTKTDTVLKAKDALEQSNAKLLGALLNKKK MKKSEHYSY*" gene complement(3348969..3349652) /gene="epsB" /locus_tag="BSU_34360" /old_locus_tag="BSU34360" CDS complement(3349658..3350362) /gene="epsA" /locus_tag="BSU_34370" /old_locus_tag="BSU34370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12970183, 15661000, 23378512, 26283769, 28950882; Product type r : regulator" /codon_start=1 /transl_table=11 /product="modulator of protein tyrosine kinase EpsB involved in biofilm matrix formation" /protein_id="NP_391317.1" /db_xref="EnsemblGenomes-Gn:BSU34370" /db_xref="EnsemblGenomes-Tr:CAB15442" /db_xref="GOA:P71050" /db_xref="InterPro:IPR003856" /db_xref="SubtiList:BG11859" /db_xref="UniProtKB/Swiss-Prot:P71050" /translation="MNENMSFKELYAIVRHRFVLILLITIGVTLIMGFVQFKVISPTY QASTQVLVHESDGEENSNLSDIQRNLQYSSTFQSIMKSTALMEEVKAELHLSESASSL KGKVVTSSENESEIINVAVQDHDPAKAAEIANTLVNKFEKEVDERMNVQGVHILSEAK ASESPMIKPARLRNMVMAFGAAVMGGITLAFFLHFLDDTCKSARQLSERTGLPCLGSV PDVHKGRNRGIKHFGE*" gene complement(3349658..3350362) /gene="epsA" /locus_tag="BSU_34370" /old_locus_tag="BSU34370" promotor_-35 3350327 /Source="Nicolas_upshift_promotors" /id="U2700" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1024 /SigmaFactorBS="cgattgtgatgagcagaatcagcacgaatctgtgtctgacaa tCgcatataattctttgaaacTCATATTCTCATTCATGTAttcatagccttcagcctt c" /listShort="slrR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3350344 /Source="Nicolas_upshifts" /id="U2700" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1024 /SigmaFactorBS="cgattgtgatgagcagaatcagcacgaatctgtgtctgacaa tCgcatataattctttgaaacTCATATTCTCATTCATGTAttcatagccttcagcctt c" /listShort="slrR" /GFF_Attribute="listLong" promotor_-10 3350347..3350365 /Source="Nicolas_upshift_promotors" /id="U2700" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1024 /SigmaFactorBS="cgattgtgatgagcagaatcagcacgaatctgtgtctgacaa tCgcatataattctttgaaacTCATATTCTCATTCATGTAttcatagccttcagcctt c" /listShort="slrR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(3350363..3350420) /Source="Nicolas_S_feature" /locus_tag="new_3529856_3529913_c" /HighExp="LoTm, BT, S3, G/S, BMM, M9-tran, S4, aero, T1.0H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.952" /TUlongSig="NA" /TUlongPSig="NA" /label="S1313" promotor_-10 complement(3350416..3350435) /Source="Nicolas_upshift_promotors" /id="U2701" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.441558441558442" /psig="0.952047952047952" /xcortree=2770 /SigmaFactorBS="aagagaacttattggcttattttgcAATTTTTAaataataac gtttTCTTTTATAATCCAATCATTaacagaaaggggcgcgggaagccagccgcgggaa g" /listShort="S1313, epsA, epsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3350421) /Source="Nicolas_upshifts" /id="U2701" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.441558441558442" /psig="0.952047952047952" /xcortree=2770 /SigmaFactorBS="aagagaacttattggcttattttgcAATTTTTAaataataac gtttTCTTTTATAATCCAATCATTaacagaaaggggcgcgggaagccagccgcgggaa g" /listShort="S1313, epsA, epsB" /GFF_Attribute="listLong" promotor_-35 complement(3350449..3350456) /Source="Nicolas_upshift_promotors" /id="U2701" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.441558441558442" /psig="0.952047952047952" /xcortree=2770 /SigmaFactorBS="aagagaacttattggcttattttgcAATTTTTAaataataac gtttTCTTTTATAATCCAATCATTaacagaaaggggcgcgggaagccagccgcgggaa g" /listShort="S1313, epsA, epsB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3350538..3350543 /Source="Nicolas_upshift_promotors" /id="U2702" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.464535464535465" /psig="0.995004995004995" /xcortree=2771 /SigmaFactorBS="cctctaatttactgcacttcccttattattttaaATTTTAta aagaacgaaaaaTTCCTTATAATGAACGAAATaacgacaggaatagaggagaatttca t" /listShort="slrR" /listLong="pnbA" /label="promotor_-35" promotor_-10 3350558..3350577 /Source="Nicolas_upshift_promotors" /id="U2702" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.464535464535465" /psig="0.995004995004995" /xcortree=2771 /SigmaFactorBS="cctctaatttactgcacttcccttattattttaaATTTTAta aagaacgaaaaaTTCCTTATAATGAACGAAATaacgacaggaatagaggagaatttca t" /listShort="slrR" /listLong="pnbA" /label="promotor_-10" upshifts 3350564 /Source="Nicolas_upshifts" /id="U2702" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.464535464535465" /psig="0.995004995004995" /xcortree=2771 /SigmaFactorBS="cctctaatttactgcacttcccttattattttaaATTTTAta aagaacgaaaaaTTCCTTATAATGAACGAAATaacgacaggaatagaggagaatttca t" /listShort="slrR" /listLong="pnbA" CDS 3350608..3351066 /gene="slrR" /locus_tag="BSU_34380" /old_locus_tag="BSU34380" /function="16.5: Explore" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18430133, 18647168, 20923420, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18430133, 18647168, 20923420, 28546427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of autolysin genes (biofilm formation)" /protein_id="NP_391318.1" /db_xref="EnsemblGenomes-Gn:BSU34380" /db_xref="EnsemblGenomes-Tr:CAB15443" /db_xref="GOA:P71049" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR036281" /db_xref="SubtiList:BG11858" /db_xref="UniProtKB/Swiss-Prot:P71049" /translation="MIGRIIRLYRKRKGYSINQLAVESGVSKSYLSKIERGVHTNPSV QFLKKVSATLEVELTELFDAETMMYEKISGGEEEWRVHLVQAVQAGMEKEELFTFTNR LKKEQPETASYRNRKLTESNIEEWKALMAEAREIGLSVHEVKSFLKTKGR*" gene 3350608..3351066 /gene="slrR" /locus_tag="BSU_34380" /old_locus_tag="BSU34380" promotor_-35 3351088..3351091 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3351097 /Source="Nicolas_upshifts" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" promotor_-10 3351108..3351126 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3351142..3352611 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7828905, 15138843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7828905, 15138843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="para-nitrobenzyl esterase (intracellular esterase B)" /protein_id="NP_391319.1" /db_xref="EnsemblGenomes-Gn:BSU34390" /db_xref="EnsemblGenomes-Tr:CAB15444" /db_xref="GOA:P37967" /db_xref="InterPro:IPR000997" /db_xref="InterPro:IPR002018" /db_xref="InterPro:IPR019819" /db_xref="InterPro:IPR019826" /db_xref="InterPro:IPR029058" /db_xref="PDB:1C7I" /db_xref="PDB:1C7J" /db_xref="PDB:1QE3" /db_xref="SubtiList:BG11844" /db_xref="UniProtKB/Swiss-Prot:P37967" /translation="MTHQIVTTQYGKVKGTTENGVHKWKGIPYAKPPVGQWRFKAPEP PEVWEDVLDATAYGSICPQPSDLLSLSYTELPRQSEDCLYVNVFAPDTPSKNLPVMVW IHGGAFYLGAGSEPLYDGSKLAAQGEVIVVTLNYRLGPFGFLHLSSFNEAYSDNLGLL DQAAALKWVRENISAFGGDPDNVTVFGESAGGMSIAALLAMPAAKGLFQKAIMESGAS RTMTKEQAASTSAAFLQVLGINEGQLDKLHTVSAEDLLKAADQLRIAEKENIFQLFFQ PALDPKTLPEEPEKAIAEGAASGIPLLIGTTRDEGYLFFTPDSDVHSQETLDAALEYL LGKPLAEKVADLYPRSLESQIHMMTDLLFWRPAVAYASAQSHYAPVWMYRFDWHPKKP PYNKAFHALELPFVFGNLDGLERMAKAEITDEVKQLSHTIQSAWITFAKTGNPSTEAV NWPAYHEETRETLILDSEITIENDPESEKRQKLFPSKGE*" gene 3351142..3352611 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" downshifts 3352588 /Source="Nicolas_upshifts" /id="D1780" /incds=0 /nref=4 /ntot=150 /MaxReadThrough="3.66738" /MaxDrop="2.70933" /score="-9.70074934" /energy="-12.2" /TU="U2703" /idTUdmin="U2703" /TUdmin="-198" /isTUend="FALSE" CDS 3352614..3352805 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514003.1" /translation="MGKTGYIGAAIVVAACIIILSAVVCLRDTVYYQPMRWTGIILFF AGIVMVPAYSAKRKPGKEK*" gene 3352614..3352805 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" downshifts 3352784 /Source="Nicolas_upshifts" /id="D1781" /incds=0 /nref=24 /ntot=181 /MaxReadThrough="-0.096" /MaxDrop="4.20686" /score="34.8993337" /energy="-22.3" /TU="NA" /idTUdmin="U2703" /TUdmin="-2" /isTUend="TRUE" CDS complement(3352832..3353317) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" /EC_number="4.1.1.102" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9546183, 12903944, 17295427, 18326577, 21685295, 26658822" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9546183, 12903944, 17295427, 18326577, 21685295, 26658822; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase" /protein_id="NP_391320.1" /db_xref="EnsemblGenomes-Gn:BSU34400" /db_xref="EnsemblGenomes-Tr:CAB15445" /db_xref="GOA:O07006" /db_xref="InterPro:IPR008729" /db_xref="InterPro:IPR012674" /db_xref="PDB:2P8G" /db_xref="PDB:4ALB" /db_xref="SubtiList:BG12433" /db_xref="UniProtKB/Swiss-Prot:O07006" /translation="MENFIGSHMIYTYENGWEYEIYIKNDHTIDYRIHSGMVAGRWVR DQEVNIVKLTEGVYKVSWTEPTGTDVSLNFMPNEKRMHGIIFFPKWVHEHPEITVCYQ NDHIDLMKESREKYETYPKYVVPEFAEITFLKNEGVDNEEVISKAPYEGMTDDIRAGR L*" gene complement(3352832..3353317) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" CDS complement(3353340..3353651) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="EnsemblGenomes-Gn:BSU34410" /db_xref="EnsemblGenomes-Tr:CAB15446" /db_xref="GOA:O07005" /db_xref="InterPro:IPR011250" /db_xref="InterPro:IPR020915" /db_xref="PSEUDO:CAB15446.2" /db_xref="SubtiList:BG12432" /db_xref="UniProtKB/Swiss-Prot:O07005" /translation="MPGGADSQMIRANGRTDLSARYVIETADHELIYIENNGIRQVSK PFRKQAAAGEIIEPEHVYFRTVPTFETGSEVYQWLHDRLFIGSAERTPDYVLLDIYEV Q*" gene complement(3353340..3353651) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /pseudo CDS complement(3353703..3353795) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU34420" /db_xref="EnsemblGenomes-Tr:CAB15447" /db_xref="PSEUDO:CAB15447.1" /db_xref="SubtiList:BG12431" /db_xref="UniProtKB/Swiss-Prot:O07004" /translation="MKKPVLKPFASLEIKVDPPITIGETSLGLR*" gene complement(3353703..3353795) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /pseudo promotor_-10 complement(3353835..3353854) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3353852) /Source="Nicolas_upshifts" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" promotor_-35 complement(3353868..3353875) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3353926..3354609) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" /EC_number="5.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9987136, 19063962, 2054383, 28894939" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 19063962, 2054383, 28894939; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aminoacid racemase (prefers arginine, lysine and ornithine)" /protein_id="NP_391323.1" /db_xref="EnsemblGenomes-Gn:BSU34430" /db_xref="EnsemblGenomes-Tr:CAB15448" /db_xref="GOA:P32960" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004380" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="SubtiList:BG10391" /db_xref="UniProtKB/Swiss-Prot:P32960" /translation="MIGILAGMGPKSTSPFIDKVIDYCQKLYGASNDIDYPHMMIYSC PTPFYADRPIDHDEMKKAIIDGAVKLEKTGVDFIALPCNTAHVYYEEIQQALSVPMLH IVEETIKEIPHPAKKAVVLGTEPTIQSAIYQKVLKGNGQEVIHKDHWQQAVNQLIAAI KQPNHMQHTQALWQTLYEEISQHADIIISACTDLNAVLDHIQSEIPIIDSSACLAKST VSTYLAYQS*" gene complement(3353926..3354609) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" downshifts complement(3353944) /Source="Nicolas_upshifts" /id="D1782" /incds=0 /nref=122 /ntot=223 /MaxReadThrough="3.49026" /MaxDrop="5.32077" /score="5.15607483" /energy="-9.3" /TU="U2705" /idTUdmin="U2704" /TUdmin="-708" /isTUend="FALSE" CDS complement(3354625..3355980) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7592498, 9987136, 12533473, 14679248, 19063962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592498, 9987136, 12533473, 14679248, 19063962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4*" /protein_id="NP_391324.1" /db_xref="EnsemblGenomes-Gn:BSU34440" /db_xref="EnsemblGenomes-Tr:CAB15449" /db_xref="GOA:P32959" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR021860" /db_xref="SubtiList:BG10390" /db_xref="UniProtKB/Swiss-Prot:P32959" /translation="MKQNKRKHLQTLFETLGEKHQFNGTVLAAEGGDILYHHSFGYAE MTEKRPLKTNSLFELASLSKPFTALGIILLEEKGILGYEDKVDRWLPGFPYQGVTIRH LLNHTSGLPDYMGWFFANWDSHKIAVNQDIVDMLMNEGLSGYFEPNEGWMYSNTGYVL LAVIIEKASGMSYADFIKTSIFLPAGMNETRVYNRRLSPERIDHYAYGYVYDVHSETY VLPDELEETNYVVYLDGIQGDGTVNSVTSDLFRFDQALYQDDFISKASKESAFSPVRL NNGETIDYGFGWVLQNSPEKGRIVSHSGGWPGYSTMMIRYIDHRKTLIYLSNKEEDTE YEQAILKAAEHILFGQPYDVPERPADKKKKAIDTAIYSRYVGSYLLQDGTAAQVTTEN ERLYLEIAGQLRLELFPSSETRFFLRALSVEVEFTLGEDAAKSFILYEDGSEEEAVRT K*" gene complement(3354625..3355980) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" promotor_-10 complement(3355992..3356007) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3356008) /Source="Nicolas_upshifts" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" promotor_-35 complement(3356019..3356028) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3356282..3356289 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3356303..3356322 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3356306 /Source="Nicolas_upshifts" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" S_feature 3356328..3356518 /Source="Nicolas_S_feature" /locus_tag="new_3535821_3536011" /HighExp="G150, G180, G135, LBGexp, Mt0, Lbexp, LBGtran, dia0, GM 150, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.219024" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1314" CDS 3356519..3357940 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" /EC_number="2.4.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levansucrase; levanase (moonlighting)" /protein_id="NP_391325.1" /db_xref="EnsemblGenomes-Gn:BSU34450" /db_xref="EnsemblGenomes-Tr:CAB15450" /db_xref="GOA:P05655" /db_xref="InterPro:IPR003469" /db_xref="InterPro:IPR023296" /db_xref="PDB:1OYG" /db_xref="PDB:1PT2" /db_xref="PDB:2VDT" /db_xref="PDB:3BYJ" /db_xref="PDB:3BYK" /db_xref="PDB:3BYL" /db_xref="PDB:3BYN" /db_xref="SubtiList:BG10388" /db_xref="UniProtKB/Swiss-Prot:P05655" /translation="MNIKKFAKQATVLTFTTALLAGGATQAFAKETNQKPYKETYGIS HITRHDMLQIPEQQKNEKYQVPEFDSSTIKNISSAKGLDVWDSWPLQNADGTVANYHG YHIVFALAGDPKNADDTSIYMFYQKVGETSIDSWKNAGRVFKDSDKFDANDSILKDQT QEWSGSATFTSDGKIRLFYTDFSGKHYGKQTLTTAQVNVSASDSSLNINGVEDYKSIF DGDGKTYQNVQQFIDEGNYSSGDNHTLRDPHYVEDKGHKYLVFEANTGTEDGYQGEES LFNKAYYGKSTSFFRQESQKLLQSDKKRTAELANGALGMIELNDDYTLKKVMKPLIAS NTVTDEIERANVFKMNGKWYLFTDSRGSKMTIDGITSNDIYMLGYVSNSLTGPYKPLN KTGLVLKMDLDPNDVTFTYSHFAVPQAKGNNVVITSYMTNRGFYADKQSTFAPSFLLN IKGKKTSVVKDSILEQGQLTVNK*" gene 3356519..3357940 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" downshifts 3357934 /Source="Nicolas_upshifts" /id="D1783" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.33324" /MaxDrop="3.39023" /score="9.57663013" /energy="-7.7" /TU="NA" /idTUdmin="U2706" /TUdmin=0 /isTUend="TRUE" CDS 3358014..3359564 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" /EC_number="3.2.1.64" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11739774, 15528654, 26773563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11739774, 15528654, 26773563; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endolevanase, selectively cleaves the (beta-2,6)fructosyl bonds" /protein_id="NP_391326.1" /db_xref="EnsemblGenomes-Gn:BSU34460" /db_xref="EnsemblGenomes-Tr:CAB15451" /db_xref="GOA:O07003" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG12430" /db_xref="UniProtKB/Swiss-Prot:O07003" /translation="MNYIKAGKWLTVFLTFLGILLFIDLFPKEEHDQKTKSKQKPDYR AAYHFTTPDKWKNDPQKPIYFDGKYHYFYLYNRDYPKGNGTEWRHAVSEDLVHWTDEG VAIPKYTNPDGDIWTGSVVVDKENTAGFGKNALVAIVTQPSAKDKKQEQYLWYSTDKG KSFKFYSGNPVMPNPGTDDFRDPKVIWDDQDNKWVMVMAEGSKIGFYESDNLKDWHYT SGFFPEQAGMVECPDLYMMRASDGTNKWVLGASANGKPWGKPNTYAYWTGSFDGKEFK ADQTEAQWLDYGFDWYGGVTFEDSKSTDPLEKRYALAWMNNWDYANNTPTMKNGFNGT DSVIRELRLKEQDGTYSLVSQPIEALEQLTVSTDEIEDQDVNGSKTLSITGDTYQLDT DLSWSELKNAGVRLRESEDQKRHIDVGIFAEGGYAYVNRAATNQPDKSNTYVESKAPY DVNKRKVHLKILVDKTTIEVFVGDGKTVFSNEVFPKPEDKGITLYSDGGTASFKNITV KHFDSIHE*" gene 3358014..3359564 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" promotor_-35 3359608..3359614 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3359628..3359639 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3359628 /Source="Nicolas_upshifts" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" CDS 3359672..3361234 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12730183, 15528654, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12730183, 15528654, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-aspartate/L-glutamate / proton permease" /protein_id="NP_391327.1" /db_xref="EnsemblGenomes-Gn:BSU34470" /db_xref="EnsemblGenomes-Tr:CAB15452" /db_xref="GOA:O07002" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12429" /db_xref="UniProtKB/Swiss-Prot:O07002" /translation="MSKQGNFQKSMSLFDLILIGMGAIFGSAWLFAVSNVASKAGPSG AFSWILGGAIILLIGLVYAELGAALPRTGGIIRYPVYSHGHLVGYLISFVTIVAYTSL ISIEVTAVRQYVAYWFPGLTIKGSDSPTISGWILQFALLCLFFLLNYWSVKTFAKANF IISIFKYIVPITIIIVLIFHFQPENLSVQGFAPFGFTGIQAAISTGGVMFAYLGLHPI VSVAGEVQNPKRNIPIALIICIIVSTIIYTVLQVTFIGAIPTETLKHGWPAIGREFSL PFKDIAVMLGLGWLATLVILDAILSPGGNGNIFMNTTSRLVYAWARNGTLFGIFSKVN KDTGTPRASLWLSFALSIFWTLPFPSWNALVNVCSVALILSYAIAPISSAALRVNAKD LNRPFYLKGMSIIGPLSFIFTAFIVYWSGWKTVSWLLGSQLVMFLIYLCFSKYTPKED VSLAQQLKSAWWLIGFYIMMLIFSYIGSFGHGLGIISNPVDLILVAIGSLAIYYWAKY TGLPKAAIDYDK*" gene 3359672..3361234 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" downshifts 3361212 /Source="Nicolas_upshifts" /id="D1784" /incds=0 /nref=12 /ntot=29 /MaxReadThrough="1.71122" /MaxDrop="3.47798" /score="-0.444529447" /energy="-11.7" /TU="NA" /idTUdmin="U2707" /TUdmin=0 /isTUend="TRUE" CDS 3361224..3361913 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391328.2" /db_xref="EnsemblGenomes-Gn:BSU34480" /db_xref="EnsemblGenomes-Tr:CAB15453" /db_xref="GOA:O07001" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:2F07" /db_xref="SubtiList:BG12428" /db_xref="UniProtKB/Swiss-Prot:O07001" /translation="MINKEARGFLASLFFTNKHTRDKMNESQSLLEVFLMPKQTSGKY EKILQAAIEVISEKGLDKASISDIVKKAGTAQGTFYLYFSSKNALIPAIAENLLTHTL DQIKGRLHGDEDFWTVLDILIDETFLITERHKDIIVLCYSGLAIDHSMEKWETIYQPY YSWLEKIINKAIANHEVTEGINSKWTARTIINLVENTAERFYIGFEQDENVEVYKKEI FTFLKRSLGTA*" gene 3361224..3361913 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" promotor_-35 3361263..3361270 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3361284..3361303 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3361293 /Source="Nicolas_upshifts" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" downshifts 3361894 /Source="Nicolas_upshifts" /id="D1785" /incds=0 /nref=189 /ntot=242 /MaxReadThrough="4.85194" /MaxDrop="4.84113" /score="-0.444529447" /energy="-11.7" /TU="U2708" /idTUdmin="U2707" /TUdmin=682 /isTUend="FALSE" downshifts complement(3361992) /Source="Nicolas_upshifts" /id="D1786" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="0.8852" /MaxDrop="3.45447" /score="0.398849185" /energy="-11.7" /TU="NA" /idTUdmin="U2709" /TUdmin=704 /isTUend="FALSE" CDS 3361995..3362330 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22978536; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium / proton antiporter subunit A" /protein_id="NP_391329.1" /db_xref="EnsemblGenomes-Gn:BSU34490" /db_xref="EnsemblGenomes-Tr:CAB15454" /db_xref="GOA:O32262" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12427" /db_xref="UniProtKB/Swiss-Prot:O32262" /translation="MNWVLVFIAGLLEVVWASSLKHADSLLDWIIIFILIAVSFILLI RSYQKIPMAAAYTVFVGIGTVGTYLTGIVLGESFSAAQMFFLALLLAGILGMKLFTKE SKSQPGGEK*" gene 3361995..3362330 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" CDS 3362330..3362650 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11160890, 22978536; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium-proton two component antiporter subunit" /protein_id="NP_391330.1" /db_xref="EnsemblGenomes-Gn:BSU34500" /db_xref="EnsemblGenomes-Tr:CAB15455" /db_xref="GOA:O06999" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12426" /db_xref="UniProtKB/Swiss-Prot:O06999" /translation="MAWFLLVIAGIEEIIAAIAMKYIDGTRKKWPIIVMTVGFGLSFY CLSQAMIVLPAGVAYAVWTGIGSIGVSAVGLIWFKERFQLSQVISLCLILAGVIGLRL TSSS*" gene 3362330..3362650 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" S_feature 3362651..3362841 /Source="Nicolas_S_feature" /locus_tag="new_3542144_3542334" /HighExp="Sw, BC, BI, Lbstat, M0t90, Lbtran, M40t90, H2O2, S8, Paraq" /AntisenseName="yvdQ" /AntisenseCor="3.5547360410813897E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1315" CDS complement(3362686..3363198) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391331.1" /db_xref="EnsemblGenomes-Gn:BSU34510" /db_xref="EnsemblGenomes-Tr:CAB15456" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR021617" /db_xref="SubtiList:BG12425" /db_xref="UniProtKB/Swiss-Prot:O06998" /translation="MGILSGNPQDEPMHYGEVFGLWSYVMAGNKMVGNYQMLLNHVGD DDLKKLLRESIEKCQDEIKQVSTILKENGVALPPASPEPPTADLNDIPPGARFLDPDV AASAAAENAAGLVTCSKMMGQSIREDIAMMFGQFHMSKAATGAKYLRLLKNKGWLIPP PLHLQKHHEA*" gene complement(3362686..3363198) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" downshifts 3362818 /Source="Nicolas_upshifts" /id="D1787" /incds=1 /nref=6 /ntot=39 /MaxReadThrough="1.61612" /MaxDrop="4.65362" /score="0.608596632" /energy="-14.2" /TU="NA" /idTUdmin="U2708" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3363234..3363245) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3363240) /Source="Nicolas_upshifts" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" promotor_-35 complement(3363260..3363266) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3363313..3363449) /Source="Nicolas_S_feature" /locus_tag="new_3542806_3542942_c" /HighExp="BT, S7, S8, S6, B36, G/S, S5, Pyr, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1316" downshifts complement(3363356) /Source="Nicolas_upshifts" /id="D1788" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.38169" /MaxDrop="2.9968" /score="15.2862513" /energy="-10.3" /TU="U2710" /idTUdmin="U2709" /TUdmin="-660" /isTUend="FALSE" CDS complement(3363450..3364793) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" /EC_number="1.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat protein; putative oxidoreductase" /protein_id="NP_391332.1" /db_xref="EnsemblGenomes-Gn:BSU34520" /db_xref="EnsemblGenomes-Tr:CAB15457" /db_xref="GOA:O06997" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12424" /db_xref="UniProtKB/Swiss-Prot:O06997" /translation="MGSTQLTGRVIFKGDPGYTEAIKNWNPYVDVYPLVFVFAQNSYD VSNAIKWARENKVPLRVRSGRHALDKNLSVVSGGIVIDVSDMNKVFLDEENAIATVQT GIPVGPLVKGLARDGFMAPFGDSPTVGIGGITMGGGFGVLSRSIGLISDNLLALKTVD AKGRIIHADQSHNEDLLWASRGGGGGNFGYNTQYTFKVHRAPKTATVFNIIWPWEQLE TVFKAWQKWAPFVDERLGCYLEIYSKINGLCHAEGIFLGSKTELIRLLKPLLHAGTPT EADIKTLYYPDAIDFLDPDEPIPGRNDQSVKFSSAWGHDFWSDEPISIMRKFLEDATG TEANFFFINWGGAISRVPKDETAFFWRHPLFYTEWTASWKNKSQEDSNLASVERVRQL MQPYVAGSYVNVPDQNIENFGKEYYGANFARLREIKAKYDPENVFRFPQSIPPSR*" gene complement(3363450..3364793) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" promotor_-10 complement(3364822..3364841) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3364830) /Source="Nicolas_upshifts" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" promotor_-35 complement(3364854..3364863) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3364855..3364860 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3364876..3364894 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3364879 /Source="Nicolas_upshifts" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 3365088..3365097 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3365106 /Source="Nicolas_upshifts" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" promotor_-10 3365111..3365130 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3365149..3366111 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 20378985" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 20378985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat lipolytic enzyme" /protein_id="NP_391333.1" /db_xref="EnsemblGenomes-Gn:BSU34530" /db_xref="EnsemblGenomes-Tr:CAB15458" /db_xref="GOA:O06996" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG12423" /db_xref="UniProtKB/Swiss-Prot:O06996" /translation="MAKYRIMTFDGGGTLGALSLQLLNRLARQNPKLISRTHVFSGNS IGSFTALALASGRSPRETLQYFEDEILPAFSISRPGGPVFNQQLPYSGFIKAVRNFFP ADLQLIDLRKRIVVPSFKLYSQKLDRWTPVLFHNFPGSPYLNEKVSDVILRSSGAPAT QRAYQNYVDGYVVATNPSTASIAFAVGKANVPLDQIAVLSIGTGEAPTRLRRDTRGWG MVSADNIRPENLKNLPPNWGVLLDRSPNEPLLPFLQMIAGGNGYYESMVSANLLGDRF FRLDPRIPNFSKTDPAVVPAVIEIANKTNLQPANQFIEKNWGSK*" gene 3365149..3366111 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" S_feature 3366112..3366365 /Source="Nicolas_S_feature" /locus_tag="new_3545605_3545858" /HighExp="BT, S8, S7, B36, S6, Pyr, G/S, S3, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1317" downshifts complement(3366392) /Source="Nicolas_upshifts" /id="D1789" /incds=0 /nref=190 /ntot=241 /MaxReadThrough="3.19421" /MaxDrop="5.60739" /score="16.7489574" /energy="-13.2" /TU="U2713" /idTUdmin="U2713" /TUdmin="-308" /isTUend="FALSE" tRNA complement(3366396..3366471) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA (CCG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(3366396..3366471) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" promotor_-10 complement(3366498..3366517) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3366519) /Source="Nicolas_upshifts" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" promotor_-35 complement(3366533..3366536) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3366602..3366608 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3366618..3366693 /Source="Nicolas_S_feature" /locus_tag="new_3546111_3546186" /HighExp="Salt, S3, S4, Etha, S5, LoTm, Gly, M9-stat, BT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1318" upshifts 3366618 /Source="Nicolas_upshifts" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" promotor_-10 3366623..3366642 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3366670..3366677 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3366691..3366710 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3366695 /Source="Nicolas_upshifts" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" CDS 3366741..3367334 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" /EC_number="3.4.21.92" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease proteolytic subunit; Maxwell's demon" /protein_id="NP_391334.1" /db_xref="EnsemblGenomes-Gn:BSU34540" /db_xref="EnsemblGenomes-Tr:CAB15459" /db_xref="GOA:P80244" /db_xref="InterPro:IPR001907" /db_xref="InterPro:IPR018215" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR033135" /db_xref="PDB:3KTG" /db_xref="PDB:3KTH" /db_xref="PDB:3KTI" /db_xref="PDB:3KTJ" /db_xref="PDB:3KTK" /db_xref="PDB:3TT6" /db_xref="PDB:3TT7" /db_xref="SubtiList:BG19016" /db_xref="UniProtKB/Swiss-Prot:P80244" /translation="MNLIPTVIEQTNRGERAYDIYSRLLKDRIIMLGSAIDDNVANSI VSQLLFLAAEDPEKEISLYINSPGGSITAGMAIYDTMQFIKPKVSTICIGMAASMGAF LLAAGEKGKRYALPNSEVMIHQPLGGAQGQATEIEIAAKRILLLRDKLNKVLAERTGQ PLEVIERDTDRDNFKSAEEALEYGLIDKILTHTEDKK*" gene 3366741..3367334 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" downshifts 3367323 /Source="Nicolas_upshifts" /id="D1790" /incds=0 /nref=292 /ntot=300 /MaxReadThrough="4.45406" /MaxDrop="8.24306" /score="30.2626808" /energy="-14.6" /TU="U2714" /idTUdmin="U2715" /TUdmin="-5" /isTUend="TRUE" S_feature 3367368..3367766 /Source="Nicolas_S_feature" /locus_tag="new_3546861_3547259" /HighExp="Etha, dia15, Heat, LoTm, M9-stat, Gly, dia5, Diami, S8, H2O2" /AntisenseName="pgcM" /AntisenseCor="0.13310786898312499" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1319" CDS complement(3367380..3368060) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" /EC_number="2.7.1.41" /EC_number="5.4.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 11081794, 15996095" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 11081794, 15996095; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional beta-phosphoglucomutase / glucose-1-phosphate phosphodismutase" /protein_id="NP_391335.1" /db_xref="EnsemblGenomes-Gn:BSU34550" /db_xref="EnsemblGenomes-Tr:CAB15460" /db_xref="GOA:O06995" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR010972" /db_xref="InterPro:IPR010976" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3NAS" /db_xref="SubtiList:BG12422" /db_xref="UniProtKB/Swiss-Prot:O06995" /translation="MKAVIFDLDGVITDTAEYHFLAWKHIAEQIDIPFDRDMNERLKG ISREESLESILIFGGAETKYTNAEKQELMHRKNRDYQMLISKLTPEDLLPGIGRLLCQ LKNENIKIGLASSSRNAPKILRRLAIIDDFHAIVDPTTLAKGKPDPDIFLTAAAMLDV SPADCAAIEDAEAGISAIKSAGMFAVGVGQGQPMLGADLVVRQTSDLTLELLHEEWEQ YRIRESIP*" gene complement(3367380..3368060) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" downshifts complement(3367404) /Source="Nicolas_upshifts" /id="D1791" /incds=0 /nref=2 /ntot=36 /MaxReadThrough="3.4944" /MaxDrop="3.50516" /score="-9.43329271" /energy="-14.6" /TU="U2718" /idTUdmin="U2718" /TUdmin="-506" /isTUend="FALSE" CDS complement(3368057..3369742) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9573215, 10229946, 1670768" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573215, 10229946, 1670768; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligo-1,4-1,6-alpha-glucosidase (sucrase-maltase-isomaltase)" /protein_id="NP_391336.1" /db_xref="EnsemblGenomes-Gn:BSU34560" /db_xref="EnsemblGenomes-Tr:CAB15461" /db_xref="GOA:O06994" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="PDB:4M56" /db_xref="PDB:4M8U" /db_xref="PDB:4MAZ" /db_xref="PDB:4MB1" /db_xref="SubtiList:BG12421" /db_xref="UniProtKB/Swiss-Prot:O06994" /translation="MSEWWKEAVVYQIYPRSFYDANGDGFGDLQGVIQKLDYIKNLGA DVIWLSPVFDSPQDDNGYDISDYKNMYEKFGTNEDMFQLIDEVHKRGMKIVMDLVVNH TSDEHAWFAESRKSKDNPYRDYYLWKDPKPDGSEPNNWGSIFSGSAWTYDEGTGQYYL HYFSKKQPDLNWENEAVRREVYDVMRFWMDRGVDGWRMDVIGSISKYTDFPDYETDHS RSYIVGRYHSNGPRLHEFIQEMNREVLSHYDCMTVGEANGSDIEEAKKYTDASRQELN MIFTFEHMDIDKEQNSPNGKWQIKPFDLIALKKTMTRWQTGLMNVGWNTLYFENHDQP RVISRWGNDRKLRKECAKAFATVLHGMKGTPFIYQGEEIGMVNSDMPLEMYDDLEIKN AYRELVVENKTMSEKEFVKAVMIKGRDHARTPMQWDAGKHAGFTAGDPWIPVNSRYQD INVKESLEDQDSIFFYYQKLIQLRKQYKIMIYGDYQLLQENDPQVFSYLREYRGEKLL VVVNLSEEKALFEAPPELIHERWKVLISNYPQERADLKSISLKPYEAVMGISI*" gene complement(3368057..3369742) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" CDS complement(3369735..3372008) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" /EC_number="2.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16707683, 28527120" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 28527120; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose phosphorylase" /protein_id="NP_391337.1" /db_xref="EnsemblGenomes-Gn:BSU34570" /db_xref="EnsemblGenomes-Tr:CAB15462" /db_xref="GOA:O06993" /db_xref="InterPro:IPR005194" /db_xref="InterPro:IPR005195" /db_xref="InterPro:IPR005196" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR017045" /db_xref="SubtiList:BG12420" /db_xref="UniProtKB/Swiss-Prot:O06993" /translation="MINQRLFEIDEWKIKTNTFNKEHTRLLESLTSLANGYMGVRGNF EEGYSGDSHQGTYIAGVWFPDKTRVGWWKNGYPEYFGKVINAMNFMGIGLYVDGEKID LHQNPIELFEVELNMKEGILRRSAVVRIQDKTVRIRSERFLSLAVKELCAIHYEAECL TGDAVITLVPYLDGNVANEDSNYQEQFWQEEAKGADSHSGHLAAKTIENPFGTPRFTV LAAMANETEGFVHESFKTTEMYVENRYSYQTKASLKKFVIVTTSRDFREEELLSKAKE LLADVVENGYEDAKRRHTDRWKERWAKADIEIKGDEELQQGIRYNIFQLFSTYYGGDA RLNIGPKGFTGEKYGGAAYWDTEAYAVPMYLATAEPEVTKNLLLYRYHQLEAAKRNAA KLGMKGALYPMVTFTGDECHNEWEITFEEIHRNGAICYAIYNYINYTGDRNYMEEYGI DVLVAVSRFWADRVHFSKRKNKYMIHGVTGPNEYENNVNNNWYTNVIAAWTLEYTLQS LESISAEKRRHLDVQEVELEVWREIIQHMYYPFSEELQIFVQHDTFLDKDLQTVDELD PAERPLYQNWSWDKILRSNFIKQADVLQGIYLFNDRFTMEEKRRNFEFYEPMTVHESS LSPSVHAILAAELKLEKKALELYKRTARLDLDNYNHDTEEGLHITSMTGSWLAIVHGF AGMRTANETLSFAPFLPKEWDEYSFNINYRNRLINVTVDEKRVIFELVKGEPLHMNVY EEPVVLQGRCERRTPNE*" gene complement(3369735..3372008) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" CDS complement(3371986..3372870) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16707683, 16850406, 20436965; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative component of maltodextrin transporter" /protein_id="NP_391338.1" /db_xref="EnsemblGenomes-Gn:BSU34580" /db_xref="EnsemblGenomes-Tr:CAB15463" /db_xref="GOA:O06992" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG12419" /db_xref="UniProtKB/Swiss-Prot:O06992" /translation="MKNLENKSFIIRCLKAAASPSGVCRYGNTFSWLQLSFLFLFLTA CLMAPLAVSFVKMDRFSVSSFMPSAIQGVNDQFADQLQGFQIRNGKLTGGKSSERIED GQNVMAVDMKHEYETSGENGRLKVTGFENAIIFQPDQLVITDQNETGFSVGYAKMDVK LEKPNVHDVEVLIDTLWLAQYKPMIMMLAYTVVSMIQLLLTFVLAGGLWITKISNMVS IASFKEAASIAICASALPAFAAAAIGMVHFDLITVLMIHSCGVTLMISFAFRYLTKTR RDNGNLHSGGNDDKSAVI*" gene complement(3371986..3372870) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" CDS complement(3372876..3373712) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transporter (permease)" /protein_id="NP_391339.1" /db_xref="EnsemblGenomes-Gn:BSU34590" /db_xref="EnsemblGenomes-Tr:CAB15464" /db_xref="GOA:O06991" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12418" /db_xref="UniProtKB/Swiss-Prot:O06991" /translation="MNASTARMLNKICTYLFLTLLSIVIIYPLLITASSAFRVGNSAA FQLDFSGSWTLDHFKRLFDETLYLNWYSNTLVIALSVMVLQVTIVTLAGYSYSRYRFA GRKKSLIFFLIIQMVPTMAALTAFYVLAMLIGALDQYWFLTAIYIGGGIPMNTWLMKG YFDTVPREIDEAARIDGAGHLRIFASIVLPLVKPMLAVQALWAFMAPFGDYLLTKFLL RSPERLTIAVGLQSFISNPQQQKVALFAAGAILAALPICVLFFFLQKNFVSGLTAGGT KG*" gene complement(3372876..3373712) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" CDS complement(3373713..3375020) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transport system (permease)" /protein_id="NP_391340.1" /db_xref="EnsemblGenomes-Gn:BSU34600" /db_xref="EnsemblGenomes-Tr:CAB15465" /db_xref="GOA:O06990" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12417" /db_xref="UniProtKB/Swiss-Prot:O06990" /translation="MNKHHTLTKQKRKAGLLSIIPGLGQIANQQLSKGLLFLAITGLF AFELCVFGIQALTGLMTLGSVPGEDHSLFMLIEGTLQLIVTMIFLMFYIFNIHDSRKT AAMKAAGLEVNTTAKDMICHAGDKGFPYLFTLPAYIMMVFVIIFPVLVTLFVALTNYD FYHIPPNRLIDWVGFKNFLNIFFLGSYRETFVNVLGWTVIWTICATTLQIILGIVTAL FVNQDFIKGKRIFRMIFLFPWAVPAFITIMSFSNMFNDSIGAVNAQVIPLFNHLPFVE LPAIAWKTDPFWTKTALIMIQTWLGFPYIYVMVTGVLQAIPGELYEAAKIDGATFIQR FRHITFPMILFATAPVMITQYTFNFNNFSIIYLFNEGGPGSAGAGAGSTDILISWIYK LTTGTSPQYSVAAAVTLLISFIVIGISLIAFKKSNAFGNEEVM*" gene complement(3373713..3375020) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" promotor_-35 3374078..3374087 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3374100..3374119 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3374104 /Source="Nicolas_upshifts" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3375060..3376313) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="maltose/maltodextrin-binding lipoprotein" /protein_id="NP_391341.1" /db_xref="EnsemblGenomes-Gn:BSU34610" /db_xref="EnsemblGenomes-Tr:CAB15466" /db_xref="GOA:O06989" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12416" /db_xref="UniProtKB/Swiss-Prot:O06989" /translation="MVLLKKGFAILAASFLAIGLAACSSSKNPASSDGKKVLTVSVEE TYKEYIESIKTKFEKENDVTVKIVEKQMFEQLEALPLDGPAGNAPDVMLAAYDRIGGL GQQGHLLDIKPSNTKSFGDKEMQQVTVDGKVYGMPLVIETLILYYNKDLLKTAPKTFK DLEKLTEDPRFAFASEKGKSTGFLAKWTDFYMSYGLLAGYGGYVFGKNGTDSGDIGLN NKGAVEAVKYAEKWFETYWPKGMQDNSSADDFIQQMFLEGKAAAIIGGPWSAANYKEA KLNYGAAPIPTLPNGEEYAPFAGGKGWVASKYTKEPELAEKWLEYAANDANAYAFYED TNEVPANTAARKKADEQKNELTSAVIKQYETATPTPNIPEMAEVWTGAESLIFDAASG KKSTQTSANDAVNVIKENIKEKYVK*" gene complement(3375060..3376313) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" S_feature complement(3376314..3376408) /Source="Nicolas_S_feature" /locus_tag="new_3555807_3555901_c" /HighExp="T1.0H, T0.30H, BC, T1.30H, M40t90, M0t90, BI, B60, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.804" /TUlongSig="NA" /TUlongPSig="NA" /label="S1320" CDS complement(3376409..3378178) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10825545, 15650689, 16707683, 19465663, 27871383, 27871383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10825545, 15650689, 16707683, 19465663, 27871383, 27871383; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maltogenic alpha-amylase" /protein_id="NP_391342.1" /db_xref="EnsemblGenomes-Gn:BSU34620" /db_xref="EnsemblGenomes-Tr:CAB15467" /db_xref="GOA:O06988" /db_xref="InterPro:IPR004185" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013777" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12415" /db_xref="UniProtKB/Swiss-Prot:O06988" /translation="MMEYAAIHHQPFSTDAYSYDGRTVHIKIRTKKGDADHIRFIWGD PYEYNDGKWSANEQPMRKIAATEMHDYWFAEVVPPFRRLQYAFVVTDDHEDIFFGSSG VCPYNEKTLETIHYYFKFPFVHEADTFQAPEWVKSTVWYQIFPERFANGREDLSPKNA LPWGSKDPDVNDFFGGDLQGIVDKLDYLEDLGVNGIYLTPIFSAPSNHKYDTLDYFSI DPHFGDPELFRTLVSQLHQRGMRIMLDAVFNHIGSASPQWQDVVKNGDQSRYKDWFHI HSFPVTDDNYDRFAFTADMPKLNTANPEVQKYLLDIALYWIREFDIDGWRLDVANEVD HVFWKTFRQAVSTEKPDVYILGEIWHSAEPWLRGDEFHAAMNYPFTEPMIEYFADQTI SASRMAHRVNAHLMNGMKQANEVMFNLLDSHDTKRLLTRCRNDEKKARALLAFMFAQT GSPCIYYGTEIGLNGENDPLCRKCMVWEKEKQNQDMLQFMKRLIALRKQENTLLTEGH LEWNLLDDKNDFISFSRTLDEKILIYFFNQGNVVQHVSLRELNIDRNKKICDAWTEQP LQHHDVIAVQPGEFLILSAAAPV*" gene complement(3376409..3378178) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" promotor_-35 3378099..3378104 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3378120..3378138 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3378130 /Source="Nicolas_upshifts" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3378216..3378235) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3378229) /Source="Nicolas_upshifts" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" promotor_-35 complement(3378248..3378255) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3378291..3379241) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16707683, 23951303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 23951303; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the maltodextrin operon (LacI family)" /protein_id="NP_391343.1" /db_xref="EnsemblGenomes-Gn:BSU34630" /db_xref="EnsemblGenomes-Tr:CAB15468" /db_xref="GOA:O06987" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12414" /db_xref="UniProtKB/Swiss-Prot:O06987" /translation="MATLSDVAKKANVSKMTVSRVINHPETVTDELKKLVHSAMKELN YIPNYAARALVQNRTQVVKLLILEEMDTTEPYYMNLLTGISRELDRNHYALQLVTRNS LNIGQCDGIIATGLRKNDFEGVIKAFEKPLVVFGQNEMGYDFIDVNNEKGTFMATRHV MGLGEREVVFFGIDLDEPFERAREQGYIRAMNKSFKKSNMFRIDNSSKKSECLARELL KSMDNQAAFVCASDRIALGVIRAAQSLGKRIPEDVAVTGNDGVFLDRISSPRLTTVRQ PVVEMGEACAKMLLKKMNEDGAAQGSLFFEPELIVRESTL*" gene complement(3378291..3379241) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" promotor_-10 complement(3379256..3379274) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3379269) /Source="Nicolas_upshifts" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3379286..3379294) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3379375) /Source="Nicolas_upshifts" /id="D1792" /incds=0 /nref=134 /ntot=243 /MaxReadThrough="0.22626" /MaxDrop="5.17193" /score="21.4455132" /energy="-10" /TU="NA" /idTUdmin="U2720" /TUdmin="-3" /isTUend="TRUE" CDS complement(3379447..3380022) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391344.1" /db_xref="EnsemblGenomes-Gn:BSU34640" /db_xref="EnsemblGenomes-Tr:CAB15469" /db_xref="InterPro:IPR005269" /db_xref="InterPro:IPR031100" /db_xref="PDB:1T35" /db_xref="SubtiList:BG12413" /db_xref="UniProtKB/Swiss-Prot:O06986" /translation="MKTICVFAGSNPGGNEAYKRKAAELGVYMAEQGIGLVYGGSRVG LMGTIADAIMENGGTAIGVMPSGLFSGEVVHQNLTELIEVNGMHERKAKMSELADGFI SMPGGFGTYEELFEVLCWAQIGIHQKPIGLYNVNGYFEPMMKMVKYSIQEGFSNESHL KLIHSSSRPDELIEQMQNYSYPILEKKWTEI*" gene complement(3379447..3380022) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" downshifts complement(3379459) /Source="Nicolas_upshifts" /id="D1793" /incds=0 /nref=30 /ntot=209 /MaxReadThrough="4.23893" /MaxDrop="3.6086" /score="21.4455132" /energy="-10" /TU="U2720" /idTUdmin="U2720" /TUdmin="-87" /isTUend="FALSE" promotor_-10 complement(3380065..3380084) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3380071..3380078 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3380081) /Source="Nicolas_upshifts" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" upshifts 3380088 /Source="Nicolas_upshifts" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" promotor_-10 3380091..3380110 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3380099..3380106) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3380139..3380459 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16120674, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrophosphohydrolase" /protein_id="NP_391345.1" /db_xref="EnsemblGenomes-Gn:BSU34650" /db_xref="EnsemblGenomes-Tr:CAB15470" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011411" /db_xref="SubtiList:BG12412" /db_xref="UniProtKB/Swiss-Prot:O32263" /translation="MQLADAEKWMKEFYEKRGWTEYGPFIRVGFLMEEAGELARAVRA YEIGRDRPDEKESSRAEQKQELIEEMGDVIGNIAILADMYGVSLEDVMKAHQEKLTKR FEHA*" gene 3380139..3380459 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" downshifts 3380440 /Source="Nicolas_upshifts" /id="D1794" /incds=0 /nref=134 /ntot=247 /MaxReadThrough="2.19085" /MaxDrop="5.46819" /score="35.8658106" /energy="-11.6" /TU="NA" /idTUdmin="U2721" /TUdmin=0 /isTUend="TRUE" downshifts complement(3380486) /Source="Nicolas_upshifts" /id="D1795" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="0.462300000000001" /MaxDrop="6.90114" /score="30.4681035" /energy="-11.3" /TU="NA" /idTUdmin="U2722" /TUdmin=8 /isTUend="TRUE" CDS complement(3380486..3382078) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion transporter" /protein_id="NP_391346.1" /db_xref="EnsemblGenomes-Gn:BSU34660" /db_xref="EnsemblGenomes-Tr:CAB15471" /db_xref="GOA:O06984" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12411" /db_xref="UniProtKB/Swiss-Prot:O06984" /translation="MRFSGRFKGYNLQKFQKDLIAGIVVGVVAIPLGMAFAIASGVEP EYGLYTVVIAGICISLFGGSKYQIGGPTGAFVPILFGIIMQYGLENLLIAGFMAGVML VLFGLFKLGKIMKFVPKPVIVGFTAGIAVLIFTEQIANFLGLRNVEKHENFHHNMFEI VQQLGTFNVYAILTAVIGLVILLVSAKVMPKVPGALLALLISTVVAVVFFPDRMATIG STYGEIPRHLPEFQFPELTLDKMVMLFPAALVIALLGGLESILSAMVADNMKGSKHDS NKELVGQGIANMAAPLFGGIPATGAIARTATNIKNGAVSPVSGVVHGVVVLLVLLVFA PYASHVPLASMAPILMVVAWNMSERKEVANMLRLKNADSFILAATFALTVLFDLIIGV ATGLLLAFVFFIRRMSEATRIHNQETHPVLAKREDPSVSMYAIEGPLFFGSIDSLESS LLEHVQKKPKTLILLMNKVHYMDTSAEAVLGNIMNRIKRHNGKLMIVGLQSQPKELLH KTGLFHKIGKQHFFDHHDEITG*" gene complement(3380486..3382078) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" CDS complement(3382097..3382690) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" /EC_number="4.2.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10611359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carbonic anhydrase" /protein_id="NP_391347.1" /db_xref="EnsemblGenomes-Gn:BSU34670" /db_xref="EnsemblGenomes-Tr:CAB15472" /db_xref="GOA:O06983" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG12410" /db_xref="UniProtKB/Swiss-Prot:O06983" /translation="MNQMVSLTSILEHNQRFVSEKKYEPYKTTKFPSKKLVIVTCMDT RLTELLPQAMGLKNGDAKIVKNAGAIVSHPFGSVMRSILVAIYELQAEEVCIVGHHEC GMSGLNASSILEKAKERGVEDSCLNLLTSAGLDLKTWLTGFHSVEESVSHSVNMIKNH PLLPKKVPVHGLVIHPETGKLDVVINGYETELINNHS*" gene complement(3382097..3382690) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" promotor_-10 complement(3382732..3382751) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3382745) /Source="Nicolas_upshifts" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" promotor_-35 complement(3382766..3382770) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3382816..3382821 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3382837..3382855 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3382838 /Source="Nicolas_upshifts" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" promotor_-35 3383011..3383018 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3383032..3383051 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3383036 /Source="Nicolas_upshifts" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" CDS 3383073..3384050 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" /EC_number="1.1.1.215" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811658, 25769838; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-ketogluconate reductase; hydroxypyruvate / glyoxylate reductase" /protein_id="NP_391348.1" /db_xref="EnsemblGenomes-Gn:BSU34680" /db_xref="EnsemblGenomes-Tr:CAB15473" /db_xref="GOA:O32264" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12409" /db_xref="UniProtKB/Swiss-Prot:O32264" /translation="MLKPFVFITKPIPEEIEAFIGEHCRYEVWQEDTLPSDVLFEKLK EAEGLLTSGTSGPSINRELLEHAPKLKVVSNQSVGYDNFDIEAMKERGVVGTHTPYTL DDTVADLAFSLILSSARRVAELDRFVRAGKWGTVEEEALFGIDVHHQTLGIIGMGRIG EQAARRAKFGFDMEVLYHNRHRKQETEDSIGVKYAELDTLLEQSDFILLITPLTDETY HMIGEREFKLMKNSAIFVNISRGKTVDEKALIRALQEGWIRGAGLDVYEKEPVTQDNP LLQLDNVTLLPHIGSATAKVRFNMCKQAAENMLAAIQGQTPKNLTREFQ*" gene 3383073..3384050 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" downshifts 3384022 /Source="Nicolas_upshifts" /id="D1796" /incds=0 /nref=223 /ntot=269 /MaxReadThrough="2.44036" /MaxDrop="5.93476" /score="1.05732532" /energy="-14.7" /TU="NA" /idTUdmin="U2724" /TUdmin="-4" /isTUend="TRUE" CDS complement(3384088..3386028) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (permease)" /protein_id="NP_391349.1" /db_xref="EnsemblGenomes-Gn:BSU34690" /db_xref="EnsemblGenomes-Tr:CAB15474" /db_xref="GOA:O06981" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG12408" /db_xref="UniProtKB/Swiss-Prot:O06981" /translation="MNLRTIARKNILGNLQRYVAYFLSCVFAVSVFFVFTSFIFHPDV NEDNIYGGSLVKTCLSAALVVIIVFCIFFITYSNSAFLQARKKEFGLLTLFGTSKQQL RKMIYYEQSLISLAAIAAGIGAGLLFSKLFFMIMTWMLSVKVPISFAIVPKAFVMTIA GFLILFQTLLILSLGRIRKLEIIELIKSAKKPKSLPVYSKWLTVLSLLCLGSGYYLSA TANAIDMMFRVFPILILVLIGTYFFFTQSSVAFFRMLYRKKHSFYKGTNIIVRSNMIF RLKDHARMLFLTSVITAVILTATGVIYMFYSDLQRQEEQSIPQSVSWVEKDASRFQVM KPETAENTLKKAHAVITYKVDATGIPVTFQSDLPYGNKKMEAEALLISEKVYNQVAKE KGFPVIHLQENEAFINVSFQMMVKDTFGEGETAAFHMKSGKTLSYVMKKQQNKGILMS VDGVSRLLVVSEKSFDSLSQDVPLKEQMRMVGYELEHWQETVDVSEKLENMVPKEHTS DFQTRAPSYQIVKQGVALMLFIGLFVSVLFFIVQGSMLYLRMFTEIEDTGVQVLALKR IGVTDKEIHSILGKQIGFLFFIPFIAGTIHAGFAYAALSNMLNSNLFLEAVIVIFIYF VFQALYYIVTRHIYKRAVLQRM*" gene complement(3384088..3386028) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" downshifts complement(3384112) /Source="Nicolas_upshifts" /id="D1797" /incds=0 /nref=11 /ntot=187 /MaxReadThrough="0.26118" /MaxDrop="4.59213" /score="26.9028733" /energy="-14.7" /TU="NA" /idTUdmin="U2725" /TUdmin=34 /isTUend="FALSE" CDS complement(3386003..3386782) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12432961, 14651641, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (ATP-binding protein)" /protein_id="NP_391350.1" /db_xref="EnsemblGenomes-Gn:BSU34700" /db_xref="EnsemblGenomes-Tr:CAB15475" /db_xref="GOA:O06980" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12407" /db_xref="UniProtKB/Swiss-Prot:O06980" /translation="MNVLQTTNLSKTYYSNKGTISYQALSAFDLSVSKGEFVGIMGPS GSGKTTLLNLLATIDKPTQGEMMINGIQPKTLKDQELALFRRRELGFVFQDFNLLDTL TIRENILLPLALDKVKLREMEARLDELADTLQIKHILDHRTYEVSGGQQQRAACARAI IHNPALILADEPTGNLDSKSAKQVMNTLAQLNEEKEATILLVTHDATAASFCKRIVFI KDGRFFSEIHRGTNRQVFYQSILDTLSVLGGDFHEFENYRP*" gene complement(3386003..3386782) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" S_feature complement(3386783..3386864) /Source="Nicolas_S_feature" /locus_tag="new_3566276_3566357_c" /HighExp="LBGtran, M0t45, H2O2, C30, Lbexp, Lbstat, LBGstat, dia0, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1321" CDS complement(3386865..3387935) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [PsdR] response to lantibiotics (nisin and gallidermin)" /protein_id="NP_391351.1" /db_xref="EnsemblGenomes-Gn:BSU34710" /db_xref="EnsemblGenomes-Tr:CAB15476" /db_xref="GOA:O06979" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12406" /db_xref="UniProtKB/Swiss-Prot:O06979" /translation="MLKTYLIDRLAIILFSLLGIGSAMLIAYLSIVESGAEPSKENMM YIWILPGTLLAAGFAADYVRQFSFLTYVKKLAEQASSSNDIGQSLKARKPRTGEQALW TKMINALGQQYESRLSQYINQQKQHYTFTNQWVHHMKTPVSVISLMIQEGKNGTSSSF PTFLEELEDENERFRHGLDMMLQTARLEEFAFDVKPQTFDLAEMVRSLINQEKRQFIK RRLFPTLHVPPNAVQISSDQKWLSFVVEQILFNALKYSKQGVGDPITIRIETQGHETR LSVADEGIGIPPQDLPRIFDAFFTGENGRTMKEATGMGLYLAKQVCSRLGHKLYAESK EGAGTVMTIVFSSDTLVNVTAL*" gene complement(3386865..3387935) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" CDS complement(3387929..3388642) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [PsdS] responding to lipid II-binding lantibiotics (nisin and gallidermin)" /protein_id="NP_391352.1" /db_xref="EnsemblGenomes-Gn:BSU34720" /db_xref="EnsemblGenomes-Tr:CAB15477" /db_xref="GOA:O06978" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12405" /db_xref="UniProtKB/Swiss-Prot:O06978" /translation="MYRILLVEDDERIASLLGGHLQKYGYEVKIAEQLNDIKLEFAEM KPDLVLLDINLPFFDGFYWCRQIRTISNAPIIFISARTDELNQVMAIENGGDDYITKP FHLEVVMAKIKSVLRRTYGEYSPSLPQESRIVELGGLTIYPDQNEAEWNSVRILFSQK EFQLLSIFVREHKKIVSRDELLEALWDDVDFVDDNTLTVNVNRLRRKLENAGLTDCIS TIRGQGYQFQVNRKDEAEC*" gene complement(3387929..3388642) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" promotor_-10 complement(3388688..3388707) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3388700) /Source="Nicolas_upshifts" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" S_feature complement(3388702..3388963) /Source="Nicolas_S_feature" /locus_tag="new_3568195_3568456_c" /HighExp="H2O2, G135, G180, Cold, Paraq, G150, dia15, Oxctl, LBGexp, C30" /AntisenseName="yvzJ" /AntisenseCor="0.56014644713727801" /AntisenseRegPval="-22.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1322" promotor_-35 complement(3388720..3388723) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3388723..3388730 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3388741..3388760 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3388746 /Source="Nicolas_upshifts" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" CDS 3388789..3388998 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="YP_003097790.1" /db_xref="EnsemblGenomes-Gn:BSU34729" /db_xref="EnsemblGenomes-Tr:CAX52696" /db_xref="GOA:C0H3R7" /db_xref="UniProtKB/Swiss-Prot:C0H3R7" /translation="MKKIMLFLAMTSILSACQPNYTGKYIEIGDTLTDYTKECFKENE IPYKYEKGKLYIPEDAFDTAIYTCS*" gene 3388789..3388998 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" downshifts 3388976 /Source="Nicolas_upshifts" /id="D1798" /incds=0 /nref=7 /ntot=138 /MaxReadThrough="1.16039" /MaxDrop="3.61604" /score="-5.58790836" /energy="-11.4" /TU="NA" /idTUdmin="U2726" /TUdmin=0 /isTUend="TRUE" downshifts complement(3389008) /Source="Nicolas_upshifts" /id="D1799" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="3.16808" /MaxDrop="2.84175" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin=44 /isTUend="FALSE" CDS complement(3389034..3389798) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10876241; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative arylamine N-acetyltransferase" /protein_id="NP_391353.1" /db_xref="EnsemblGenomes-Gn:BSU34730" /db_xref="EnsemblGenomes-Tr:CAB15478" /db_xref="GOA:O06977" /db_xref="InterPro:IPR001447" /db_xref="SubtiList:BG12404" /db_xref="UniProtKB/Swiss-Prot:O06977" /translation="MIKMSDFLKDCFQKIGWEKDHVSFGDLPLFLKAMAYRFPFENRA VLAKENYKITKEELWRRLLKDQHGGLCYDLNGFLYFVLREAGFHVKLIRGTVYAGDQE GWALEGTHAAVWLSAENGDYLVDIGFGINLALQPIPLSGETVQSPVGSFRIKKEETEK GSYVLLMDKGEGWQIGYAFTLEESDLGDLDNMKDIIHSHEKSPFNKSLLASKLTPSGR MVMSERHFTIYENGGNIQKSDIGPSGFEEKLNTHFL*" gene complement(3389034..3389798) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" downshifts complement(3389056) /Source="Nicolas_upshifts" /id="D1800" /incds=0 /nref=143 /ntot=253 /MaxReadThrough="3.19848" /MaxDrop="6.45069" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin="-4" /isTUend="TRUE" CDS complement(3389799..3390056) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="catabolite repression HPr-like protein" /protein_id="NP_391354.1" /db_xref="EnsemblGenomes-Gn:BSU34740" /db_xref="EnsemblGenomes-Tr:CAB15479" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1K1C" /db_xref="PDB:1MO1" /db_xref="PDB:1MU4" /db_xref="PDB:1ZVV" /db_xref="PDB:2AK7" /db_xref="PDB:2RLZ" /db_xref="SubtiList:BG12403" /db_xref="UniProtKB/Swiss-Prot:O06976" /translation="MVQQKVEVRLKTGLQARPAALFVQEANRFTSDVFLEKDGKKVNA KSIMGLMSLAVSTGTEVTLIAQGEDEQEALEKLAAYVQEEV*" gene complement(3389799..3390056) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" CDS complement(3390080..3391030) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10986251, 17603302, 19836336, 24097947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative morphogen" /protein_id="NP_391355.1" /db_xref="EnsemblGenomes-Gn:BSU34750" /db_xref="EnsemblGenomes-Tr:CAB15480" /db_xref="GOA:O06975" /db_xref="InterPro:IPR003802" /db_xref="InterPro:IPR018478" /db_xref="InterPro:IPR023054" /db_xref="InterPro:IPR027434" /db_xref="InterPro:IPR033981" /db_xref="SubtiList:BG12402" /db_xref="UniProtKB/Swiss-Prot:O06975" /translation="MSFASETKKELTNLEVKDCCINAELSALIRMNGALSFTNRHLVL DVQTENAAIARRIYTLLKKQYDVSVELLVRKKMRLKKNNVYIVRFSENAKAILEDLKI LGENFVFERSISKELVKKRCCKRSYMRGAFLAGGSVNNPETSSYHLEIFSLYKEHNDS LCDLLNEFQLNSKTLERKKGYITYLKEAEKITEFLNVIGAHNSLLRFEDVRIVRDMRN SVNRLVNCETANLNKTIGASLRQVENIKYIDERIGLEALPEKLREIAQLRIDYQEVTL KELGEMVASGKISKSGINHRLRKLDEIAEQLRTGQTVTLK*" gene complement(3390080..3391030) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" CDS complement(3391053..3392006) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159; Product type f: factor" /codon_start=1 /transl_table=11 /product="gluconeogenesis morphogenetic factor (UDP-sugar binding)" /protein_id="NP_391356.2" /db_xref="EnsemblGenomes-Gn:BSU34760" /db_xref="EnsemblGenomes-Tr:CAB15481" /db_xref="GOA:O06974" /db_xref="InterPro:IPR002882" /db_xref="InterPro:IPR010119" /db_xref="SubtiList:BG12401" /db_xref="UniProtKB/Swiss-Prot:O06974" /translation="MGQKPKIAIFGGGTGLSVLLRGLKHKPVDITAIVTVADDGGSSG RLRNELKIPPPGDIRNVLAALSDVEPLVEDLFQHRFNKGNDLTGHSLGNLILAAMTNI TGDFFHAVTEMSKVLNVRGKVLPAANASVVLHAEMEDGRVVSGESTIPEYGQRIKRVF LTPEQIDPLPETIDVIREADLIIIGPGSLYTSILPNLLVPKIGEEVIKAPAKKVYICN VMTQPGETLHYTAADHVKALNQHMGCGFIDTILVNSEDIPDEIKRKYEMESARPVDFD IEELKAMGLEVIRDQIVTYKNDVIRHDTHKVASLLVDLLKE*" gene complement(3391053..3392006) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" CDS complement(3392008..3392895) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" /function="15.6: DNA transformation" /experiment="publication(s) with functional evidences, PMID:18334534, 19074378, 21179021, 21709426" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18334534, 19074378, 21179021, 21709426; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase possibly involved in regulator sRNA degradation" /protein_id="NP_391357.1" /db_xref="EnsemblGenomes-Gn:BSU34770" /db_xref="EnsemblGenomes-Tr:CAB15482" /db_xref="GOA:O06973" /db_xref="InterPro:IPR005337" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12400" /db_xref="UniProtKB/Swiss-Prot:O06973" /translation="MSVSESHDIQLVIITGMSGAGKTVAIQSFEDLGYFCVDNLPPSL LPKFLELMKESNSKMSKVALVMDLRGREFFDRLIEALDEMAENPWITPRILFLDAKDS ILVTRYKETRRSHPLAATGLPLEGIALERELLEELKGRSQIIYDTSDMKPRDLREKIV KHFATNQGETFTVNVMSFGFKYGIPIDADLVFDVRFLPNPYYIESMRPLTGKDKEVSS YVMKWNETQKFNEKLIDLLSFMLPSYKREGKSQVVIAIGCTGGQHRSVTLAENLADYF KKDYYTHVTHRDIEKRSRK*" gene complement(3392008..3392895) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" CDS complement(3392920..3393396) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" /EC_number="3.6.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative triphosphate pyrophosphate hydrolase" /protein_id="NP_391358.1" /db_xref="EnsemblGenomes-Gn:BSU34780" /db_xref="EnsemblGenomes-Tr:CAB15483" /db_xref="GOA:O06972" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG12399" /db_xref="UniProtKB/Swiss-Prot:O06972" /translation="MTYLQRVTNCVLQTDDKVLLLQKPRRGWWVAPGGKMESGESVRD SVIREYREETGIYIINPQLKGVFTFIIKDGDHIVSEWMMFTFVADSYTGQNVSESEEG KLQWHDVNDIQNLPMAPGDGHILDFMMKGQGLLHGTFTYTPEFELLSYRLDPQHIK*" gene complement(3392920..3393396) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" promotor_-10 complement(3393416..3393435) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3393430) /Source="Nicolas_upshifts" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" promotor_-35 complement(3393451..3393455) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3393474..3393493) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3393487) /Source="Nicolas_upshifts" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" promotor_-35 complement(3393508..3393511) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3393563..3393713) /Source="Nicolas_S_feature" /locus_tag="new_3573056_3573206_c" /HighExp="dia15, Diami, dia5, H2O2, Etha, LPhT, Cold, Paraq, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1323" downshifts complement(3393606) /Source="Nicolas_upshifts" /id="D1801" /incds=0 /nref=9 /ntot=78 /MaxReadThrough="6.94979" /MaxDrop="3.73811" /score="11.9453839" /energy="-11" /TU="U2729,U2733" /idTUdmin="U2734" /TUdmin=2904 /isTUend="FALSE" CDS complement(3393714..3394664) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" /EC_number="1.8.1.9" /function="16.6: Maintain" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14597697, 15659166, 23813734, 24401092" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14597697, 15659166, 23813734, 24401092; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thioredoxin reductase" /protein_id="NP_391359.1" /db_xref="EnsemblGenomes-Gn:BSU34790" /db_xref="EnsemblGenomes-Tr:CAB15484" /db_xref="GOA:P80880" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR005982" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12398" /db_xref="UniProtKB/Swiss-Prot:P80880" /translation="MSEEKIYDVIIIGAGPAGMTAAVYTSRANLSTLMIERGIPGGQM ANTEDVENYPGFESILGPELSNKMFEHAKKFGAEYAYGDIKEVIDGKEYKVVKAGSKE YKARAVIIAAGAEYKKIGVPGEKELGGRGVSYCAVCDGAFFKGKELVVVGGGDSAVEE GVYLTRFASKVTIVHRRDKLRAQSILQARAFDNEKVDFLWNKTVKEIHEENGKVGNVT LVDTVTGEESEFKTDGVFIYIGMLPLSKPFENLGITNEEGYIETNDRMETKVEGIFAA GDIREKSLRQIVTATGDGSIAAQSVQHYVEELQETLKTLK*" gene complement(3393714..3394664) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" S_feature complement(3394665..3394752) /Source="Nicolas_S_feature" /locus_tag="new_3574158_3574245_c" /HighExp="dia5, Diami, dia15, H2O2, Etha, Salt, Cold, Paraq, LPhT, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1324" promotor_-10 complement(3394741..3394760) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3394752) /Source="Nicolas_upshifts" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" S_feature complement(3394754..3394845) /Source="Nicolas_S_feature" /locus_tag="new_3574247_3574338_c" /HighExp="Cold, Oxctl, G180, G135, Paraq, C30, LBGexp, G150, S1, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1325" promotor_-35 complement(3394775..3394778) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3394793..3394799 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3394813..3394831 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3394827 /Source="Nicolas_upshifts" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" S_feature 3394828..3398214 /Source="Nicolas_S_feature" /locus_tag="new_3574321_3577707" /HighExp="Sw, M9-stat, B60, T0.30H, Gly, BC, B36, T1.0H, Salt, C30" /AntisenseName="yvcD" /AntisenseCor="-0.261780844003138" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1326" CDS complement(3394870..3396291) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" /EC_number="3.4.-.-" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted cell wall DL-endopeptidase" /protein_id="NP_391360.1" /db_xref="EnsemblGenomes-Gn:BSU34800" /db_xref="EnsemblGenomes-Tr:CAB15485" /db_xref="GOA:P40767" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG11023" /db_xref="UniProtKB/Swiss-Prot:P40767" /translation="MRKSLITLGLASVIGTSSFLIPFTSKTASAETLDEKKQKIESKQ SEVASSIEAKEKELTELQENQSKIEKELKDINDKALDTSNKIEDKKEENDKTKEEIKK LKKEIKETEARIEKRNEILKKRVRSLQESGGSQGYIDVLLGSTSFGDFISRATAVSSI VDADKDLIKQQEQDKAKLEDSEADLNDKLKEVQAALAKLETMQKDLDKQLNEKDKLFD EAKASQKKTAKAISELKSEASELANQKANTEAEQARIKKEQEAAAALIKKQEEAQKAS DETQTDDSQTATTESSKASSSDDSSDNSSDNSSNGSSNSSSNGSSSKKSSGSNSNSGG TVISNSGGIEGAISVGSSIVGQSPYKFGGGRTQSDINNRIFDCSSFVRWAYASAGVNL GPVGGTTTDTLVGRGQAVSASEMKRGDLVFFDTYKTNGHVGIYLGNGTFLNDNTSHGV SVDSMSNPYWKAAFKGVVRRVVQ*" gene complement(3394870..3396291) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" downshifts complement(3394890) /Source="Nicolas_upshifts" /id="D1802" /incds=0 /nref=8 /ntot=106 /MaxReadThrough="6.31311" /MaxDrop="3.4602" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1620 /isTUend="FALSE" downshifts complement(3395014) /Source="Nicolas_upshifts" /id="D1803" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="7.07718" /MaxDrop="2.13349" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1496 /isTUend="FALSE" misc_feature 3395918..3395922 /Source="Nicolas_upshift_promotors" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3395928 /Source="Nicolas_upshifts" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 3396207..3396211 /Source="Nicolas_upshift_promotors" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3396214 /Source="Nicolas_upshifts" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(3396292..3396489) /Source="Nicolas_S_feature" /locus_tag="new_3575785_3575982_c" /HighExp="S1, Cold, T-3.40H, M9-exp, MG t5, MG 5, MG 15, T-5.40H, GM-0.2, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1327" downshifts 3396412 /Source="Nicolas_upshifts" /id="D1804" /incds=0 /nref=2 /ntot=119 /MaxReadThrough="6.41604" /MaxDrop="3.8522" /score="6.14322693" /energy="-7.6" /TU="U2730,U2731" /idTUdmin="U2731" /TUdmin="-1408" /isTUend="FALSE" promotor_-10 complement(3396477..3396496) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-10" upshifts complement(3396489) /Source="Nicolas_upshifts" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" promotor_-35 complement(3396508..3396515) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-35" CDS complement(3396672..3398126) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391361.1" /db_xref="EnsemblGenomes-Gn:BSU34810" /db_xref="EnsemblGenomes-Tr:CAB15486" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12396" /db_xref="UniProtKB/Swiss-Prot:O06968" /translation="MGKHTSEHKNHAQIVQLLQDGQYFFHKGLKAYKERNLKRASKLI QRAVHLEPEDSEMLSQLAVIYSEMGQYQESNDLLDYIMANLEAEMPECHYFKANNFAH LGLFQEAYKEAAAYSDADPDGEFAEENDSLLDLLDLGDDGIEDSLYDQDELLVKQDRA KSLLESGQLAEAVAALEEITTEYPELWSAYNNLALAYFYSGNVVKAKQTAYEVLSHNE GNLHALCNLLVFYYYEREDEKVAELSDQLSNVYPMLLEQRYKLGATLALVGRYEIGYK WLKSLYKTGFEGDDTFFYWLSCSAYFTGHTDFAETIWRKVESQYPGEDRPAPWIERRE ALPSSVEQRLAAYYISSTKGETEHLEAVIRSKRITAPFETHFVKLLLNGDSAAADVSE DALFAYQTVKLLEQAEKEEMKTEVMSCWVFHVIQQIRAAAPLKNEKGWAAAICYIWKE AHGKQDTKKDTAARFGISPATLTKYMKYIDDILE*" gene complement(3396672..3398126) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" downshifts complement(3396692) /Source="Nicolas_upshifts" /id="D1805" /incds=0 /nref=11 /ntot=190 /MaxReadThrough="3.36188" /MaxDrop="3.98985" /score="16.3455178" /energy="-9.1" /TU="U2734" /idTUdmin="U2734" /TUdmin="-182" /isTUend="FALSE" S_feature complement(3398127..3398251) /Source="Nicolas_S_feature" /locus_tag="new_3577620_3577744_c" /HighExp="LBGstat, Sw, Cold, BC, BI, Lbexp, dia0, G150, LBGtran, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1328" downshifts 3398172 /Source="Nicolas_upshifts" /id="D1806" /incds=0 /nref=4 /ntot=36 /MaxReadThrough="1.81602" /MaxDrop="3.41181" /score="7.59889121" /energy="-9.9" /TU="NA" /idTUdmin="U2730" /TUdmin=0 /isTUend="TRUE" CDS complement(3398252..3400021) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16405427, 18215075, 21077936, 22711831, 24630999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16405427, 18215075, 21077936, 22711831, 24630999; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter (ATP-binding and permease protein)" /protein_id="NP_391362.1" /db_xref="EnsemblGenomes-Gn:BSU34820" /db_xref="EnsemblGenomes-Tr:CAB15487" /db_xref="GOA:O06967" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12395" /db_xref="UniProtKB/Swiss-Prot:O06967" /translation="MPTKKQKSKSKLKPFFALVRRTNPSYGKLAFALALSVVTTLVSL LIPLLTKQLVDGFSMSNLSGTQIGLIALVFFVQAGLSAYATYALNYNGQKIISGLREL LWKKLIKLPVSYFDTNASGETVSRVTNDTMVVKELITTHISGFITGIISVIGSLTILF IMNWKLTLLVLVVVPLAALILVPIGRKMFSISRETQDETARFTGLLNQILPEIRLVKA SNAEDVEYGRGKMGISSLFKLGVREAKVQSLVGPLISLVLMAALVAVIGYGGMQVSSG ELTAGALVAFILYLFQIIMPMGQITTFFTQLQKSIGATERMIEILAEEEEDTVTGKQI ENAHLPIQLDRVSFGYKPDQLILKEVSAVIEAGKVTAIVGPSGGGKTTLFKLLERFYS PTAGTIRLGDEPVDTYSLESWREHIGYVSQESPLMSGTIRENICYGLERDVTDAEIEK AAEMAYALNFIKELPNQFDTEVGERGIMLSGGQRQRIAIARALLRNPSILMLDEATSS LDSQSEKSVQQALEVLMEGRTTIVIAHRLSTVVDADQLLFVEKGEITGRGTHHELMAS HGLYRDFAEQQLKMNADLENKAG*" gene complement(3398252..3400021) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" S_feature complement(3400022..3400096) /Source="Nicolas_S_feature" /locus_tag="new_3579515_3579589_c" /HighExp="LBGstat, Cold, Lbexp, G150, Oxctl, dia0, T1.30H, T0.30H, BC, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1329" misc_feature complement(3400085..3400104) /Source="Nicolas_upshift_promotors" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3400096) /Source="Nicolas_upshifts" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" CDS complement(3400186..3400545) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391363.1" /db_xref="EnsemblGenomes-Gn:BSU34830" /db_xref="EnsemblGenomes-Tr:CAB15488" /db_xref="SubtiList:BG14157" /db_xref="UniProtKB/Swiss-Prot:O32265" /translation="MTSLFSESETEIVSTTYMFLTQDEMKGKAGTLNQPINDFLSLTK KFESSLKEEIKGQKGLIVKKIKKELESNSEKRKAALQMIKEEHTAKVDRYKMIIEDLR QQDVTLTYRKKKPVKDV*" gene complement(3400186..3400545) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" downshifts complement(3400206) /Source="Nicolas_upshifts" /id="D1807" /incds=0 /nref=146 /ntot=246 /MaxReadThrough="2.52417" /MaxDrop="4.81771" /score="18.5636016" /energy="-13.2" /TU="NA" /idTUdmin="U2735" /TUdmin=0 /isTUend="TRUE" CDS complement(3400560..3402470) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391364.1" /db_xref="EnsemblGenomes-Gn:BSU34840" /db_xref="EnsemblGenomes-Tr:CAB15489" /db_xref="SubtiList:BG12394" /db_xref="UniProtKB/Swiss-Prot:O06966" /translation="MGNKNVFENENVKLRLIDLEYDYKQKFASTIASEVKKAKKDFEA DIRRIYKEETHHDLPENMKIEIYTSNELVNQNTSIQSSTRESGYDGTAIHIIDEKKHI DQLQIISEGSADNKDWSYNFFGLFLGIDHSQYEATKEFTNKAKKAAGNSEDLKTFALG HSLANNNQVMVQLIDGEYDEVYGVNGAQVNIDQLLETDESLYRYVIRKFSYKYEDIDS IPPEKLKKEIQKYYEDKGVTTNITQRISKDDPLYGVSGKADFITFGDVKMADTNTSVK GIRNIMDGVPDEDVRSIQKFLQKYKDDYEKDGLNGFIKAASGIDIDLIEKVKNTDGAL KKVSVLYEHFDDVKQMYGRIKEELPSFLGFLHTLLRNSGPVVDQLAENGYIDETQKKV IKKELTNINASMRGIESRYEHFIDHLKHGQFMQALKDVGEIVDYVKSILSSLKTLDTE TKDALKLIVDGHSIVQMLNALSKEKGFSYKGSDIYFTGKSGSGETIQVNLSSAVRIYQ NGMKIVEDMEDAISKYQKVYSQEIDEDFIDKKQAIITAIHHMEENPSHYAFDLQFRLA AGFSHTFDKLEKISVHESFHTGALPANDGIVAELKKQTTEKRDFIKNIRESIEKLFEK EEMISQLFDFQS*" gene complement(3400560..3402470) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" CDS complement(3402472..3403197) /gene="yvcA" /locus_tag="BSU_34850" /old_locus_tag="BSU34850" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17590234; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391365.1" /db_xref="EnsemblGenomes-Gn:BSU34850" /db_xref="EnsemblGenomes-Tr:CAB15490" /db_xref="GOA:O06965" /db_xref="SubtiList:BG12393" /db_xref="UniProtKB/Swiss-Prot:O06965" /translation="MKKIIFICFSLLLALTGGCSMNDNDKNSTNDNKTEAVKPKDMDP KDLPQVPAFQDEKTREYMVSTKEEEPGYYLLESKLKGFRMLFPEDGKYLSRRSSLTGK NKESIGFNSYDKDTNVMFDGHVTYYKEESFANEPKTMLDIVSGKNDYKGEYKKSSKKK TDIYTAKKKDIFDDIDRKYNYSYSYFGYVKSTEEDNLGVEYAFTLGCKNENQPCSLDE EKAKNKVEKLINSITFLIDKKEK*" gene complement(3402472..3403197) /gene="yvcA" /locus_tag="BSU_34850" /old_locus_tag="BSU34850" S_feature complement(3403198..3403286) /Source="Nicolas_S_feature" /locus_tag="new_3582691_3582779_c" /HighExp="T1.30H, T0.30H, T1.0H, T2.0H, T2.30H, T3.0H, T-1.40H, T-1.10H, MG 150, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.982, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1330" promotor_-10 complement(3403286..3403305) /Source="Nicolas_upshift_promotors" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3403286) /Source="Nicolas_upshifts" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" S_feature complement(3403288..3403417) /Source="Nicolas_S_feature" /locus_tag="new_3582781_3582910_c" /HighExp="Etha, Diami, HiTm, T1.0H, Cold, MG 15, T0.30H, BMM, T1.30H, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1331" promotor_-35 complement(3403321..3403324) /Source="Nicolas_upshift_promotors" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3403443..3404072) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" /EC_number="3.5.4.19" /EC_number="3.6.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15871048, 17767732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase" /protein_id="NP_391366.1" /db_xref="EnsemblGenomes-Gn:BSU34860" /db_xref="EnsemblGenomes-Tr:CAB15491" /db_xref="GOA:O34912" /db_xref="InterPro:IPR002496" /db_xref="InterPro:IPR008179" /db_xref="InterPro:IPR021130" /db_xref="InterPro:IPR023019" /db_xref="InterPro:IPR026660" /db_xref="SubtiList:BG12603" /db_xref="UniProtKB/Swiss-Prot:O34912" /translation="MKQADELRFNEDGLIPAIVQDAASKEVLTLAYMNKESYEKTLET KETWFYSRSRQALWHKGETSGNTQAVKGIRYDCDQDALLVLVEPSGPACHTGSYSCFT KEQTEEQAADRFGIMNELERVIAERQAEMPEGAYTTYLFREGVDKILKKVGEEASEVI IAAKNRDHEELKWEAADLLYHLLVLLREQSLPLDDVLDVLKKRHSEIEE*" gene complement(3403443..3404072) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" downshifts complement(3403462) /Source="Nicolas_upshifts" /id="D1808" /incds=0 /nref=104 /ntot=178 /MaxReadThrough="4.37156" /MaxDrop="4.76747" /score="14.9565762" /energy="-8.4" /TU="U2738" /idTUdmin="U2735" /TUdmin="-3256" /isTUend="FALSE" CDS complement(3404069..3404827) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" /EC_number="4.3.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 17767732, 19636909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase subunit" /protein_id="NP_391367.1" /db_xref="EnsemblGenomes-Gn:BSU34870" /db_xref="EnsemblGenomes-Tr:CAB15492" /db_xref="GOA:O34727" /db_xref="InterPro:IPR004651" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG12600" /db_xref="UniProtKB/Swiss-Prot:O34727" /translation="MITKRIIPCLDVKEGRVVKGIQFLELKDAGDPVELAEVYDREGA DELVFLDISASHEGRKTMVDVVEQVAAKLAIPFTVGGGINQLSDMKTILRAGADKVSV NTAAVLRPELITEGAEFFGSQCIVLAIDAKYDKESDTYKVYTHGGRKKTDWEVTAWAK EGVKRGAGEILLTSMDSDGEKKGFDHTLTKLVSEAVPVPVIASGGAGNAQHMLEAFTK GEADAALAASIFHYKETSIKEVKSYLKEYGVNVR*" gene complement(3404069..3404827) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" CDS complement(3404824..3405561) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" /EC_number="5.3.1.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 26294764; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase" /protein_id="NP_391368.1" /db_xref="EnsemblGenomes-Gn:BSU34880" /db_xref="EnsemblGenomes-Tr:CAB15493" /db_xref="GOA:O35006" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR006063" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023016" /db_xref="SubtiList:BG12597" /db_xref="UniProtKB/Swiss-Prot:O35006" /translation="MSAFTLYPAIDMRNGKCVRLVQGDYNKETIYGDSPYDMAELFEK EGAEWIHLVDLDGAKEGKRVNDRHVIEIAQKLNLKVEIGGGIRSENDVYEYLSAGVER VILGSSAVSNPPFVKKMLKQYGEKIAIGLDARNGFVSTEGWLETSTLKATELGKELAN EGAEVFIFTDIATDGMLSGPNVKSTVELAKETGKSVIASGGVSSVADLEALARNEADG VSGAIIGKALYTNQFTLSEALERVKRK*" gene complement(3404824..3405561) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" CDS complement(3405558..3406196) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" /EC_number="2.4.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 15301532" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 15301532; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase, glutamineamidotransferase subunit" /protein_id="NP_391369.1" /db_xref="EnsemblGenomes-Gn:BSU34890" /db_xref="EnsemblGenomes-Tr:CAB15494" /db_xref="GOA:O34565" /db_xref="InterPro:IPR010139" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12602" /db_xref="UniProtKB/Swiss-Prot:O34565" /translation="MIGVIDYGMGNLYSVSKALERVGVPYFVSEKPEELKEADAFILP GVGSFGDAMDNLGYTKLDQLIHDMVSEGRLLLGICLGMQLLFEESEENGTASGLGLLK GKAVRLKAEDEKGNKLKVPHMGWNRLSFHNESPLLTKTEQGYAYFVHSYYIDGMEENA LLASADYGVRVPAVVGKRNVFGAQFHPEKSSTVGMSILTQFTKMAAEQKVKK*" gene complement(3405558..3406196) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" promotor_no_box 3406054..3406154 /Source="Nicolas_upshift_promotors" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3406114 /Source="Nicolas_upshifts" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3406197..3406781) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" /EC_number="4.2.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 24311587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazoleglycerol-phosphate dehydratase [Mn(II)-dependent]" /protein_id="NP_391370.1" /db_xref="EnsemblGenomes-Gn:BSU34900" /db_xref="EnsemblGenomes-Tr:CAB15495" /db_xref="GOA:O34683" /db_xref="InterPro:IPR000807" /db_xref="InterPro:IPR020565" /db_xref="InterPro:IPR020568" /db_xref="SubtiList:BG12598" /db_xref="UniProtKB/Swiss-Prot:O34683" /translation="MRKAERVRKTNETDIELAFTIDGGGQADIKTDVPFMTHMLDLFT KHGQFDLSINAKGDVDIDDHHTTEDIGICLGQALLEALGDKKGIKRYGSAFVPMDEAL AQVVIDLSNRPHLEMRADFPAAKVGTFDTELVHEFLWKLALEARMNLHVIVHYGTNTH HMIEAVFKALGRALDEATTIDPRVKGIPSTKGML*" gene complement(3406197..3406781) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" CDS complement(3406778..3408061) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" /EC_number="1.1.1.23" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10353847, 10353848, 21672513, 24140957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol dehydrogenase" /protein_id="NP_391371.1" /db_xref="EnsemblGenomes-Gn:BSU34910" /db_xref="EnsemblGenomes-Tr:CAB15496" /db_xref="GOA:O34651" /db_xref="InterPro:IPR001692" /db_xref="InterPro:IPR012131" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR022695" /db_xref="SubtiList:BG12599" /db_xref="UniProtKB/Swiss-Prot:O34651" /translation="MKIKTISGAERLSLKRSIDAGTEEQRKTVRSIIEDVKANGDQAV RSYTAKFDCIEIDSPLVTKEEFEEAYTSLDSRLLQVIRQAIENIREYHERQLQSSWFY HRKDGTMLGQKVTALDSAGVYVPGGTAAYPSSVLMNVIPALVAGVERIVLVTPPGKDG LLSPGVLVAAAELGIKDIYKMGGAQAIAALAYGTETIEPVDKITGPGNIYVALAKREV FGDVDIDMIAGPSEIVVLADETAIPSEIAADLLSQAEHDKLSSCVFVTDSMALAETVS AEVNKQLETLPRREIAEASVRDYGCIYVAETMVEAIETVNTLAPEHLEIITQSPEALL GSIKHAGAIFLGRYSPEPVGDYFAGPNHVLPTNGTARFSSPLNVTDFQKKSSIISYSQ SAFEEHAESIAAFARLEGLEAHARSIEARERRISK*" gene complement(3406778..3408061) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" CDS complement(3408058..3408699) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" /EC_number="2.4.2.17" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 14741209, 15660995, 17154531, 21774583, 22989207, 28092443, 28872824; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP phosphoribosyltransferase" /protein_id="NP_391372.1" /db_xref="EnsemblGenomes-Gn:BSU34920" /db_xref="EnsemblGenomes-Tr:CAB15497" /db_xref="GOA:O34520" /db_xref="InterPro:IPR001348" /db_xref="InterPro:IPR013820" /db_xref="InterPro:IPR018198" /db_xref="InterPro:IPR024893" /db_xref="PDB:2VD2" /db_xref="SubtiList:BG12601" /db_xref="UniProtKB/Swiss-Prot:O34520" /translation="MGKLLTMAMPKGRIFEEAAGLLRQAGYRLPEEFEDSRKLIIDVP EENLRFILAKPMDVTTYVEHGVADVGIAGKDVMLEEERDVYEVLDLNISKCHLAVAGL PNTDWSGVAPRIATKYPNVASSYFREQGEQVEIIKLNGSIELAPLIGLADRIVDIVST GQTLKENGLVETEHICDITSRFIVNPVSYRMKDDVIDEMASRLSLVVEGETAK*" gene complement(3408058..3408699) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" CDS complement(3408692..3409867) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" /EC_number="2.4.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 15660995; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase-like subunit of ATP phophoribosyltransferase" /protein_id="NP_391373.1" /db_xref="EnsemblGenomes-Gn:BSU34930" /db_xref="EnsemblGenomes-Tr:CAB15498" /db_xref="GOA:O34459" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR004517" /db_xref="InterPro:IPR006195" /db_xref="SubtiList:BG12606" /db_xref="UniProtKB/Swiss-Prot:O34459" /translation="MFMFEKPHGMRDTLPGLYETKKKVRRSLTDLIDKWGYQFMETPT LEFYDTVGVQSAIEEQQLFKLLDQDGKTLVLRPDMTGPIARVAASKLLKHGHPLRVGY AANVFRAQEREGGRPAEFEQVGVELIGDGTTSADAEVIALVVGALKNAGLASFKIAIG HAGIADALFVEVLGNVERADVLRRFLYEKNYVGYREHVKSLPLSSIDKSRLLELLELR GGIEVCGRAEEIVDSAQGKSVVDELKALWDILEDYGCTENVRLDLNMVSHMSYYTGIL FEVYAENVGFVIGSGGRYNKLLGHFDSPAPATGFGLRIDRLIEALHMKDEPCEIDAVI FSKEQRAQAIAYANEERMKGNKVVLQDLSGIENIDQMTKSFANVTYFIGARKEEQNG* " gene complement(3408692..3409867) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" S_feature complement(3409868..3409945) /Source="Nicolas_S_feature" /locus_tag="new_3589361_3589438_c" /HighExp="Diami, M/G, Etha, BMM, MG 15, MG 10, T-1.10H, T-0.40H, T-1.40H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1332" promotor_-35 3409911..3409917 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3409929..3409948 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3409929..3409948) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3409942 /Source="Nicolas_upshifts" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(3409945) /Source="Nicolas_upshifts" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" promotor_-35 complement(3409961..3409968) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3410077..3410096 /Source="Nicolas_upshift_promotors" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3410084 /Source="Nicolas_upshifts" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" CDS 3410118..3410870 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydratase" /protein_id="NP_391374.1" /db_xref="EnsemblGenomes-Gn:BSU34940" /db_xref="EnsemblGenomes-Tr:CAB15499" /db_xref="InterPro:IPR016997" /db_xref="SubtiList:BG14130" /db_xref="UniProtKB/Swiss-Prot:O34735" /translation="MKTLRTLCVLMILSGVIFFGLKIDAKDIDIPFLNSLKKVVSDSD TDSAANSKKELKGSAKPLDVILYNQMDAPRLYNGCEVTSLAMVLNYAGYDVTKNTLAN QVATVPLTYSSGLKGDPNDGFVGDMANGPGLGVYHRPIYQLAKTYAGDKVSDLTGKSI SAVYQQLEKGNPVWVITTANFTPVDNMQTWKTPNGTIEITYSEHSVAVTGYDDKYVYL NDPYGYKNRKTDRTSFEKAWKQMGSQAVVIQK*" gene 3410118..3410870 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" S_feature 3410871..3411109 /Source="Nicolas_S_feature" /locus_tag="new_3590364_3590602" /HighExp="LBGstat, LPhT, Cold, Sw, M/G, G180, G135, LBGtran, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1333" promotor_-10 complement(3410892..3410903) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3410898) /Source="Nicolas_upshifts" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3410918..3410924) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3411110..3411775 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10658655, 15187182, 16514142, 20000851, 24236123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658655, 15187182, 16514142, 20000851, 24236123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted pectate (polygalacturonate) lyase" /protein_id="NP_391375.1" /db_xref="EnsemblGenomes-Gn:BSU34950" /db_xref="EnsemblGenomes-Tr:CAB15500" /db_xref="GOA:O34310" /db_xref="InterPro:IPR004898" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG14129" /db_xref="UniProtKB/Swiss-Prot:O34310" /translation="MKKIVSILFMFGLVMGFSQFQPSTVFAADKVVHETIIVPKNTTY DGKGQRFVAGKELGDGSQSENQDPVFRVEDGATLKNVVLGAPAADGVHTYGNVNIQNV KWEDVGEDALTVKKEGKVTIDGGSAQKASDKIFQINKASTFTVKNFTADNGGKFIRQL GGSTFHVDVIIDKCTITNMKEAIFRTDSKTSTVRMTNTRYSNVGQKWIGVQHIYENNN TQF*" gene 3411110..3411775 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" downshifts 3411746 /Source="Nicolas_upshifts" /id="D1809" /incds=0 /nref=85 /ntot=213 /MaxReadThrough="1.40389" /MaxDrop="4.93342" /score="16.0973385" /energy="-14.9" /TU="NA" /idTUdmin="U2739" /TUdmin=176 /isTUend="FALSE" CDS complement(3411795..3412313) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21761520, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21761520, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphorylated heptaprenylglyceryl phosphate O-acetyltransferase" /protein_id="NP_391376.1" /db_xref="EnsemblGenomes-Gn:BSU34960" /db_xref="EnsemblGenomes-Tr:CAB15501" /db_xref="GOA:O34993" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="SubtiList:BG14128" /db_xref="UniProtKB/Swiss-Prot:O34993" /translation="MRKTDRHPVSGANSLWHVYQTVPFLKVVKNFIVIQIARYTPFIG MKNWLYRTFLRMKVGKQTSFALMVMPDIMFPEKISVGTNTIIGYNTTILAHEYLIHEY RIGKVLIGDEVMIGANTTILPGVKIGDGAVVSAGTLVHKDVPDGAFVGGNPMRIIYTK EEMQERLKKSAE*" gene complement(3411795..3412313) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" downshifts complement(3411829) /Source="Nicolas_upshifts" /id="D1810" /incds=0 /nref=245 /ntot=283 /MaxReadThrough="1.27998" /MaxDrop="6.44997" /score="38.2106579" /energy="-14.9" /TU="NA" /idTUdmin="U2741" /TUdmin="-7" /isTUend="TRUE" CDS complement(3412317..3412967) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" /EC_number="3.6.1.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9465101, 12359880, 12411438, 16182622, 22353596" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9465101, 12359880, 12411438, 16182622, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Hpr-associated pyrophosphatase" /protein_id="NP_391377.1" /db_xref="EnsemblGenomes-Gn:BSU34970" /db_xref="EnsemblGenomes-Tr:CAB15502" /db_xref="GOA:Q9JMQ2" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023733" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14127" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ2" /translation="MSDKQVTTILFDLDGTLINTNELIIASFLHTLEHYYPSKYKRED VLAFIGPSLFDTFSSMDPDKCEDMIAMYRAYNHDMHDSLVTEYETVYETLDALKKAGF TLGIVTTKLRDTVNMGLKLTGIGEFFETVVTLDDVTNAKPDPEPVLLALKQLGSEPAE AIMVGDNYHDVLAGKNAGTKTAGVAWTIKGPEMLAKHEPDFMLEKMSDLLQIVGVK*" gene complement(3412317..3412967) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" CDS complement(3412964..3413902) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27226549; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein with nucleotide binding domain" /protein_id="NP_391378.1" /db_xref="EnsemblGenomes-Gn:BSU34980" /db_xref="EnsemblGenomes-Tr:CAB15503" /db_xref="GOA:O34382" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG14126" /db_xref="UniProtKB/Swiss-Prot:O34382" /translation="MKKIFLAGLAAGFQTTWTLGKVIFPVTLLVTLLQHTPVMDWLVR LITPVMGLFGLSGEAAIPLVLGNMLNLYAGIAGILTLDLSVKEVFILAVMLSFCHNLI IESTVAAKVGIRIGVILAVRIGLAAVSAIVINLIWHGGKETAQYGFIAAKSAAPDSWL GMLAEALTKAGLGVLQLAAIVIPLMIIIQFLRDLGWLYRFSRWLSPFTQLLGMNKNTS MTMVTGLTIGLAYGAGVMIKAVEDDGVSKRDMTLAFIFLVACHAVVEDTLVFIPLGIP VWPLLLIRVTTAVLLTMAIAHTWKKWKPSAVGKEAI*" gene complement(3412964..3413902) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" CDS complement(3413926..3414735) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" /EC_number="2.4.99.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prelipoprotein diacylglycerol transferase" /protein_id="NP_391379.1" /db_xref="EnsemblGenomes-Gn:BSU34990" /db_xref="EnsemblGenomes-Tr:CAB15504" /db_xref="GOA:O34752" /db_xref="InterPro:IPR001640" /db_xref="SubtiList:BG12611" /db_xref="UniProtKB/Swiss-Prot:O34752" /translation="MNEAIEPLNPIAFQLGPLAVHWYGIIIGLGALLGLWIAMRESEK RGLQKDTFIDLVLFAIPIAIICARIYYVAFEWDYYAAHPGEIIKIWKGGIAIHGGLIG AILTGYVFSRVKNLSFWKLADIAAPSILLGQAIGRWGNFMNQEAHGEAVSRAFLENLH LPEFIINQMYINGQYYHPTFLYESLWSFVGVIVLLLLRRANLRRGEMFLIYIIWYSIG RYFIEGMRTDSLMLTDSLRIAQVISIVLIVLAVAAIIFRRVKGYSKERYAE*" gene complement(3413926..3414735) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" CDS complement(3414749..3415681) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" /EC_number="2.7.4.-" /EC_number="2.7.11.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine protein kinase/phosphorylase (pyrophosphate-producing)" /protein_id="NP_391380.1" /db_xref="EnsemblGenomes-Gn:BSU35000" /db_xref="EnsemblGenomes-Tr:CAB15505" /db_xref="GOA:O34483" /db_xref="InterPro:IPR003755" /db_xref="InterPro:IPR011104" /db_xref="InterPro:IPR011126" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG14125" /db_xref="UniProtKB/Swiss-Prot:O34483" /translation="MAKVRTKDVMEQFNLELISGEEGINRPITMSDLSRPGIEIAGYF TYYPRERVQLLGKTELSFFEQLPEEEKKQRMDSLCTDVTPAIILSRDMPIPQELIDAS EKNGVPVLRSPLKTTRLSSRLTNFLESRLAPTTAIHGVLVDIYGVGVLITGKSGVGKS ETALELVKRGHRLVADDCVEIRQEDQDTLVGNAPELIEHLLEIRGLGIINVMTLFGAG AVRSNKRITIVMNLELWEQGKQYDRLGLEEETMKIIDTEITKLTIPVRPGRNLAVIIE VAAMNFRLKRMGLNAAEQFTNKLADVIEDGEQEE*" gene complement(3414749..3415681) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" promotor_-10 complement(3415723..3415742) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3415729) /Source="Nicolas_upshifts" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" promotor_-35 complement(3415758..3415763) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3415798..3415805 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3415817 /Source="Nicolas_upshifts" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" promotor_-10 3415820..3415837 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3415863..3417053 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" /EC_number="3.5.1.25" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6774970, 14557261, 21602348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6774970, 14557261, 21602348; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosamine-6-phosphate deacetylase" /protein_id="NP_391381.1" /db_xref="EnsemblGenomes-Gn:BSU35010" /db_xref="EnsemblGenomes-Tr:CAB15506" /db_xref="GOA:O34450" /db_xref="InterPro:IPR003764" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2VHL" /db_xref="SubtiList:BG12630" /db_xref="UniProtKB/Swiss-Prot:O34450" /translation="MAESLLIKDIAIVTENEVIKNGYVGINDGKISTVSTERPKEPYS KEIQAPADSVLLPGMIDIHIHGGYGADTMDASFSTLDIMSSRLPEEGTTSFLATTITQ EHGNISQALVNAREWKAAEESSLLGAELLGIHLEGPFVSPKRAGAQPKEWIRPSDVEL FKKWQQEAGGLIKIVTLAPEEDQHFELIRHLKDESIIASMGHTDADSALLSDAAKAGA SHMTHLYNAMSPFHHREPGVIGTALAHDGFVTELIADGIHSHPLAAKLAFLAKGSSKL ILITDSMRAKGLKDGVYEFGGQSVTVRGRTALLSDGTLAGSILKMNEGARHMREFTNC SWTDIANITSENAAKQLGIFDRKGSVTVGKDADLVIVSSDCEVILTICRGNIAFISKE ADQI*" gene 3415863..3417053 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" promotor_-35 3416851..3416857 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3416872 /Source="Nicolas_upshifts" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" promotor_-10 3416873..3416891 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3417050..3417778 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" /EC_number="3.5.99.6" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15755726, 18436239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 18436239; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate isomerase" /protein_id="NP_391382.1" /db_xref="EnsemblGenomes-Gn:BSU35020" /db_xref="EnsemblGenomes-Tr:CAB15507" /db_xref="GOA:O35000" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="PDB:2BKV" /db_xref="PDB:2BKX" /db_xref="SubtiList:BG12631" /db_xref="UniProtKB/Swiss-Prot:O35000" /translation="MKVMECQTYEELSQIAARITADTIKEKPDAVLGLATGGTPEGTY RQLIRLHQTENLSFQNITTVNLDEYAGLSSDDPNSYHFYMNDRFFQHIDSKPSRHFIP NGNADDLEAECRRYEQLVDSLGDTDIQLLGIGRNGHIGFNEPGTSFKSRTHVVTLNEQ TRQANARYFPSIDSVPKKALTMGIQTILSSKRILLLISGKSKAEAVRKLLEGNISEDF PASALHLHSDVTVLIDREAASLRP*" gene 3417050..3417778 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" CDS 3417796..3418527 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" /experiment="publication(s) with functional evidences, PMID:16207374, 20047956, 21602348, 23667565, 24673833, 26162881" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 20047956, 21602348, 23667565, 24673833, 26162881; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_391383.1" /db_xref="EnsemblGenomes-Gn:BSU35030" /db_xref="EnsemblGenomes-Tr:CAB15508" /db_xref="GOA:O34817" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2WV0" /db_xref="PDB:4U0V" /db_xref="PDB:4U0W" /db_xref="PDB:4U0Y" /db_xref="PDB:4WWC" /db_xref="SubtiList:BG14124" /db_xref="UniProtKB/Swiss-Prot:O34817" /translation="MNINKQSPIPIYYQIMEQLKTQIKNGELQPDMPLPSEREYAEQF GISRMTVRQALSNLVNEGLLYRLKGRGTFVSKPKMEQALQGLTSFTEDMKSRGMTPGS RLIDYQLIDSTEELAAILGCGHPSSIHKITRVRLANDIPMAIESSHIPFELAGELNES HFQSSIYDHIERYNSIPISRAKQELEPSAATTEEANILGIQKGAPVLLIKRTTYLQNG TAFEHAKSVYRGDRYTFVHYMDRLS*" gene 3417796..3418527 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" CDS complement(3418547..3422416) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_391384.1" /db_xref="EnsemblGenomes-Gn:BSU35040" /db_xref="EnsemblGenomes-Tr:CAB15509" /db_xref="GOA:O34986" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR011401" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036415" /db_xref="SubtiList:BG14123" /db_xref="UniProtKB/Swiss-Prot:O34986" /translation="MRKYTVIASILLSFLSVLSGGHHESKAFPVVQQELFQTPHYIPL LENPPQIDVKAEMRSNLMIEAQVRDNSYQAFSAFLFYKQSNELGYKMVPMDPTPGAVR KFLAQIPKRLIWNSELEYYIVMSNGKQRVESETKKLKLEGYQADLAHIPELLITELAV DTKNIGRADGYEFIEIFNTTDRTIDFKDYHIRYRYPKEGPDSDLIWRPDERILIPSGE TFVVWLKPAGHPELTSADFNRYYQTQLKEGKNLAVIDETEGMANTRPRAVVISTNTGK DISVAHYRKHALRRLSSVLYKYPLNGTAELLNISIGEKNPSPGTVLQAQVPDQKRKIK LDKEKPVIEDLTDRKPVRPAESIELRADIRDRSLVKTVAFYYRTDENKPFKRILAEKD RNDNLFHYIVYSPELIGKDQLEYYVAAGDGINEARTPVKMIDIKQTSKAHGLRMNIEN RDTLSGTQFLKATTEGRADSIKLWIDGKKQVTEPAMEKEVYFAFDTRKTNLYFKNAVT MEGKVLKVFDDTTNKYRTYSVPLPETLLRKGKQLQRITIRSGSKVSPFDTAENRDDFL VKNARLVLSDGTVIRDQRVSPEKELFIGDNQRSNKSWQFQFNLPDGLFTSQLLEWDTS KLSEGAHHIQASDGKENVSLVVRVDNSGPHIEPNITEGQTYKGNLILQADMYDKWSRI EEAEASLDGESITLPYHTSSSDLLPGKHSLKVTATDLAGNKTVIERIFKTEREHPDQP EVIDSEADTHKAKLSVRVKDPTNDAMDVGFYRGFQYTARNHVKIFKHASLTEPPKSFV PERETPFTNKELERVSAADGKTVSTENKELFPYHRFEVTVDPSIDENDLAESVWKGSS LPGRKVTMYAWNYRTNEWQPVDSFVAKDDKPFTLKASVIAADFVRESKMNVIVQDEIP PAKDMYTFVWMSDTQYYAESYPHIFDKQTEWIKDNQKQLNIKYVFHTGDIVDDSADIR QWKNADRSMSVLDKSGIPYGVLAGNHDVGHKDGSYRAFGKYFGSDRFDKKFHYGGSYK NNRGHYDLISSNGNDYIMLYMGWGITDEDIAWMNQVLKKHPDRMAILAFHEYLLVSGN RSPIGEKIFKEIVKPNPNVVMVLSGHYHSAMRKTDELDDDGDGKPDRLVHQMLADYQG GPEGGQGYLRLLQFDQANDMVHVSTYSPYVKDKNYYDTDTYGNKDEFSLSLDLKPRIK KVETDYFECNVYTNEELGKREQVKSGDTAEFRWDHLEPQSVYYWYIIVEDSFNGKTKS PIWKFKTKKETYRPAPDQFDFRHVSNP*" gene complement(3418547..3422416) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" downshifts complement(3418669) /Source="Nicolas_upshifts" /id="D1811" /incds=1 /nref=19 /ntot=109 /MaxReadThrough="1.28942" /MaxDrop="4.39575" /score="28.0438848" /energy="-16.5" /TU="NA" /idTUdmin="U2744" /TUdmin="-5" /isTUend="TRUE" promotor_-10 complement(3422436..3422447) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3422443) /Source="Nicolas_upshifts" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" promotor_-35 complement(3422462..3422468) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3422506..3422512 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3422526..3422545 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3422531 /Source="Nicolas_upshifts" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" CDS 3422581..3423054 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391385.1" /db_xref="EnsemblGenomes-Gn:BSU35050" /db_xref="EnsemblGenomes-Tr:CAB15510" /db_xref="GOA:O34692" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14122" /db_xref="UniProtKB/Swiss-Prot:O34692" /translation="MDNSIHDELFQAIQQFALKRDKRVWQKVQIPSIGISSQHHDHLK KDWTLTQLHIVSCIHTSQNVNNSFLASRLHISKAAVSKAVHALLKHNIITVTKKPGNK KEIFYTLTDSGRKLAALHEQLHEKAKEQYKQLFNEFSIDDLKTVTAFFNLWIKYM*" gene 3422581..3423054 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" S_feature 3423055..3423162 /Source="Nicolas_S_feature" /locus_tag="new_3602548_3602655" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, T2.30H, M9-stat, T2.0H, T1.30H, T1.0H, BC" /AntisenseName="cypX" /AntisenseCor="-1.1473096183385199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1334" CDS complement(3423095..3424312) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" /EC_number="1.14.-.-" /function="16.5: Explore" /function="16.14: Store" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:4204912, 20690619, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 20690619, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclo-L-leucyl-L-leucyl dipeptide oxidase, pulcheriminic synthase" /protein_id="NP_391386.1" /db_xref="EnsemblGenomes-Gn:BSU35060" /db_xref="EnsemblGenomes-Tr:CAB15511" /db_xref="GOA:O34926" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR030904" /db_xref="InterPro:IPR036396" /db_xref="PDB:3NC3" /db_xref="PDB:3NC5" /db_xref="PDB:3NC6" /db_xref="PDB:3NC7" /db_xref="SubtiList:BG12580" /db_xref="UniProtKB/Swiss-Prot:O34926" /translation="MSQSIKLFSVLSDQFQNNPYAYFSQLREEDPVHYEESIDSYFIS RYHDVRYILQHPDIFTTKSLVERAEPVMRGPVLAQMHGKEHSAKRRIVVRSFIGDALD HLSPLIKQNAENLLAPYLERGKSDLVNDFGKTFAVCVTMDMLGLDKRDHEKISEWHSG VADFITSISQSPEARAHSLWCSEQLSQYLMPVIKERRVNPGSDLISILCTSEYEGMAL SDKDILALILNVLLAATEPADKTLALMIYHLLNNPEQMNDVLADRSLVPRAIAETLRY KPPVQLIPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAFEQPDVFNIHREDLGIK SAFSGAARHLAFGSGIHNCVGAAFAKNEIEIVANIVLDKMRNIRLEEDFCYAESGLYT RGPVSLLVAFDGA*" gene complement(3423095..3424312) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" downshifts complement(3423108) /Source="Nicolas_upshifts" /id="D1812" /incds=0 /nref=11 /ntot=50 /MaxReadThrough="2.27112" /MaxDrop="6.67384" /score="-0.264310319" /energy="-11.6" /TU="NA" /idTUdmin="U2747" /TUdmin=0 /isTUend="TRUE" promotor_-35 3423134..3423139 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3423154..3423165 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3423164..3423449 /Source="Nicolas_S_feature" /locus_tag="new_3602657_3602942" /HighExp="BC, Sw, Lbstat, T5.0H, M9-stat, T4.0H, T3.30H, B60, T1.30H, T0.30H" /AntisenseName="cypX" /AntisenseCor="-4.04991056466339E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.438, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1335" upshifts 3423164 /Source="Nicolas_upshifts" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" downshifts 3423406 /Source="Nicolas_upshifts" /id="D1813" /incds=1 /nref=9 /ntot=165 /MaxReadThrough="3.27492" /MaxDrop="3.99509" /score="54.0406126" /energy="-11.4" /TU="U2745,U2746" /idTUdmin="U2746" /TUdmin="-44" /isTUend="FALSE" CDS complement(3424328..3425074) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" /EC_number="6.-.-.-" /function="16.14: Store" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:4204912, 19430487, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 19430487, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclodipeptide synthase (tRNA-dependent), pulcherimminic acid precursor" /protein_id="NP_391387.1" /db_xref="EnsemblGenomes-Gn:BSU35070" /db_xref="EnsemblGenomes-Tr:CAB15512" /db_xref="GOA:O34351" /db_xref="InterPro:IPR030903" /db_xref="SubtiList:BG14121" /db_xref="UniProtKB/Swiss-Prot:O34351" /translation="MTGMVTERRSVHFIAEALTENCREIFERRRHVLVGISPFNSRFS EDYIYRLIGWAKAQFKSVSVLLAGHEAANLLEALGTPRGKAERKVRKEVSRNRRFAER ALVAHGGDPKAIHTFSDFIDNKAYQLLRQEVEHAFFEQPHFRHACLDMSREAIIGRAR GVSLMMEEVSEDMLNLAVEYVIAELPFFIGAPDILEVEETLLAYHRPWKLGEKISNHE FSICMRPNQGYLIVQEMAQMLSEKRITSEG*" gene complement(3424328..3425074) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" S_feature complement(3425075..3425261) /Source="Nicolas_S_feature" /locus_tag="new_3604568_3604754_c" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T3.0H, T1.0H, B36, BT, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1336" promotor_-10 complement(3425247..3425266) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3425261) /Source="Nicolas_upshifts" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" promotor_-35 complement(3425280..3425287) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3425395..3425402 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3425417..3425436 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3425429 /Source="Nicolas_upshifts" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" S_feature 3425430..3425499 /Source="Nicolas_S_feature" /locus_tag="new_3604923_3604992" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T1.0H, T0.30H, B36, T3.0H, BT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1337" CDS 3425500..3426009 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27542896; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for pulcherriminic acid synthesis" /protein_id="NP_391388.1" /db_xref="EnsemblGenomes-Gn:BSU35080" /db_xref="EnsemblGenomes-Tr:CAB15513" /db_xref="GOA:P40762" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11018" /db_xref="UniProtKB/Swiss-Prot:P40762" /translation="MSDLTKQMIYDIYVRLLHLNEQKANTSLQQFFKEAAEEDVAEIP KNMTSIHVIDCIGQHEPINNAGIARKMNLSKANVTKISTKLIKEEFINSYQLTDNKKE VYFKLTRKGRRIFDLHEKLHKKKELAFYQFLDSFSQEEQKAVLKFLEQLTSTLEAEQT DGTPDKPVK*" gene 3425500..3426009 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" S_feature complement(3425905..3427243) /Source="Nicolas_S_feature" /locus_tag="new_3605398_3606736_c" /HighExp="T0.30H, T1.0H, T1.30H, T-0.40H, T0.0H, T2.0H, G135, T2.30H, T-1.10H, G180" /AntisenseName="yvmA" /AntisenseCor="0.2423954904641" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1338" downshifts complement(3425946) /Source="Nicolas_upshifts" /id="D1814" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.42525" /MaxDrop="2.72496" /score="14.1278884" /energy="-7.8" /TU="NA" /idTUdmin="U2749" /TUdmin=0 /isTUend="TRUE" CDS 3426030..3427241 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27542896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pulcherriminic acid efflux transporter" /protein_id="NP_391389.1" /db_xref="EnsemblGenomes-Gn:BSU35090" /db_xref="EnsemblGenomes-Tr:CAB15514" /db_xref="GOA:O34307" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14120" /db_xref="UniProtKB/Swiss-Prot:O34307" /translation="MAHTKSKAVLILYTVCFSAFFASLSQNIYSPILPIIKESFHVST AMVNLSVSVFMIVTAIMQIILGAIIDFKGARIVLITGILATAAASIGCAVTTDFTLFL IFRMIQAAGSAALPLIAATTIGQLFTGNERGSAMGTYQMLLSVAPAIAPVLGGFIGGA AGYEGIFWILAAISIVLLVTNSITFPKDSPTESMQQAKGNVFAHYKSIFTNRTGNVIL TLSFVLFFIYFAVIVYLPILLTEHYHIDVGIAGLLYLPLALSTIAGTFLFKRIQAKIG LHTLFIGSNVIAACSIILFAVTHSVSLVLMALTLALFGISMGVIPPLYSTMITNEFEH NRGSAIGMFNFIRYTGMAAGPMVSAYLLTMMPSAMSFSLLGLGFAALSFCLLPPMFSP QKRTKQKKHHM*" gene 3426030..3427241 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" downshifts 3427239 /Source="Nicolas_upshifts" /id="D1815" /incds=0 /nref=33 /ntot=196 /MaxReadThrough="5.27186" /MaxDrop="4.73361" /score="54.0406126" /energy="-11.4" /TU="U2748" /idTUdmin="U2748" /TUdmin="-721" /isTUend="FALSE" CDS complement(3427269..3427628) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26296725; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral phage holin-like membrane protein" /protein_id="NP_391390.1" /db_xref="EnsemblGenomes-Gn:BSU35100" /db_xref="EnsemblGenomes-Tr:CAB15515" /db_xref="GOA:O34648" /db_xref="InterPro:IPR007165" /db_xref="SubtiList:BG14119" /db_xref="UniProtKB/Swiss-Prot:O34648" /translation="MVKWAVSILVNALLLIVIDGYIDSIHISSIGAAIIASLILSILN VLIKPLLIIFTLPVTMVTLGLFLFVINAITLMMTASIMGDSFQIDGFGTAIWASVILS VFHLLIQKGILEPLRKK*" gene complement(3427269..3427628) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" S_feature 3427284..3428000 /Source="Nicolas_S_feature" /locus_tag="new_3606777_3607493" /HighExp="LBGstat, S8, Gly, C30, G135, S7, C90, Sw, Fru, S6" /AntisenseName="yvlC" /AntisenseCor="0.178445666283919" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1339" downshifts complement(3427288) /Source="Nicolas_upshifts" /id="D1816" /incds=0 /nref=129 /ntot=265 /MaxReadThrough="4.63835" /MaxDrop="5.15146" /score="14.4434545" /energy="-9.6" /TU="U2749" /idTUdmin="U2751" /TUdmin=0 /isTUend="TRUE" CDS complement(3427630..3427827) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23980836; Product type r : regulator" /codon_start=1 /transl_table=11 /product="membrane associated phage-like stress regulator,nisin resistance" /protein_id="NP_391391.1" /db_xref="EnsemblGenomes-Gn:BSU35110" /db_xref="EnsemblGenomes-Tr:CAB15516" /db_xref="GOA:O34719" /db_xref="InterPro:IPR007168" /db_xref="SubtiList:BG14118" /db_xref="UniProtKB/Swiss-Prot:O34719" /translation="MNKLYRSEKNKKIAGVIGGLAEYFNWDASLLRVITVILAIMTSV LPVLLIYIIWIFIVPSERDMK*" gene complement(3427630..3427827) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" CDS complement(3427832..3428929) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function, stress-related" /protein_id="NP_391392.1" /db_xref="EnsemblGenomes-Gn:BSU35120" /db_xref="EnsemblGenomes-Tr:CAB15517" /db_xref="InterPro:IPR016599" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14117" /db_xref="UniProtKB/Swiss-Prot:O34628" /translation="MKQEKERILKLVEEGKLTAQEALTLIEKLDSDYKEKEEKITALS VHVHDEEEPFTTAKKESGKPSLGAKLFDWIDSAVKKVKEVDLDLNFGHAYDVQHIFQF KDTDFSSVELQIANGSVNIVPWEDDDIRAECQAKVYRADSQDAARHAFLQHIECEIKG NKFFIRTEKKTMKTNVTLYIPQKEYDKIRVKLFNGPVRGEHLHVKEFSAKTTNGVLSF SYLTAEKAIAETANGQIKLASHSCGTIEAETINGLIDLRGKSESIDVQSFNGNIAINV TESDCRSIYAKTTTGNVELAIPDDLAVKAELKSNLGTLSHELMDVEMLKEKNDTIQKE MMFTSNQAHDQNITVFSESLTGAIKLKYSQR*" gene complement(3427832..3428929) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" CDS complement(3428954..3429280) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391393.1" /db_xref="EnsemblGenomes-Gn:BSU35130" /db_xref="EnsemblGenomes-Tr:CAB15518" /db_xref="GOA:O34322" /db_xref="SubtiList:BG14116" /db_xref="UniProtKB/Swiss-Prot:O34322" /translation="MNRNQAIIASLCYFSVFIAPIIVPIVAYFVVNEKETKRHAIRSL ISHIVPFVGWLFLFIALLGGAVAIDGDSLLPVFVIIGGAVIYFLVVIGIIIWNVIQGI KVLRAA*" gene complement(3428954..3429280) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" promotor_-10 complement(3429333..3429348) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3429348) /Source="Nicolas_upshifts" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" S_feature complement(3429350..3429840) /Source="Nicolas_S_feature" /locus_tag="new_3608843_3609333_c" /HighExp="H2O2, G180, Paraq, G150, G135, dia15, Oxctl, Diami, Lbexp, LBGexp" /AntisenseName="yvkN" /AntisenseCor="0.37678416921083902" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1340" promotor_-35 complement(3429360..3429369) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3429428..3429431 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3429446..3429465 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3429456 /Source="Nicolas_upshifts" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" CDS 3429498..3429728 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391394.1" /db_xref="EnsemblGenomes-Gn:BSU35140" /db_xref="EnsemblGenomes-Tr:CAB15519" /db_xref="SubtiList:BG14115" /db_xref="UniProtKB/Swiss-Prot:O34604" /translation="MEKDPSDYTVTQESVLKLIQEQKRMNREMITELEQIHGPFPISH DIQYIKVLLDSSNTHIVQDLMSVSKQLYKKTL*" gene 3429498..3429728 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" promotor_-10 complement(3429831..3429850) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-10" upshifts complement(3429841) /Source="Nicolas_upshifts" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" promotor_-35 complement(3429866..3429870) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-35" CDS complement(3429927..3430409) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16936039; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="putative flagellin" /db_xref="EnsemblGenomes-Gn:BSU35150" /db_xref="EnsemblGenomes-Tr:CAB15520" /db_xref="GOA:O34366" /db_xref="InterPro:IPR001029" /db_xref="PSEUDO:CAB15520.1" /db_xref="SubtiList:BG14158" /db_xref="UniProtKB/Swiss-Prot:O34366" /translation="MDALIEEVDGISNRTEFNGKKLLDGTETDGFTFQIGANAGQQLT VNIDSMSSTALGVNALNVTDFANTPFDTQLESIDTAINNVSNQRAKLGAVQNRLEHTI NNLGASSENLTAAESRIRDVDMAKEMSEFTKNNIPSQASQAMLAQANQQPQNVLQLLR *" gene complement(3429927..3430409) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /pseudo downshifts 3429935 /Source="Nicolas_upshifts" /id="D1817" /incds=0 /nref=13 /ntot=113 /MaxReadThrough="0.9814" /MaxDrop="4.76969" /score="2.6592903" /energy="-5.7" /TU="NA" /idTUdmin="U2750" /TUdmin=17 /isTUend="TRUE" downshifts complement(3429950) /Source="Nicolas_upshifts" /id="D1818" /incds=0 /nref=118 /ntot=206 /MaxReadThrough="2.62918" /MaxDrop="8.97968" /score="25.6132739" /energy="-19.8" /TU="NA" /idTUdmin="U2752" /TUdmin=0 /isTUend="TRUE" upshifts complement(3430082) /Source="Nicolas_upshifts" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(3430090..3430093) /Source="Nicolas_upshift_promotors" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3430170..3430174) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3430170) /Source="Nicolas_upshifts" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3430190..3430193) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3430410..3430543) /Source="Nicolas_S_feature" /locus_tag="new_3609903_3610036_c" /HighExp="H2O2, Sw, M40t45, M40t90, Diami, Salt, dia15, BC, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1341" CDS complement(3430571..3433444) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit A)" /protein_id="NP_391396.1" /db_xref="EnsemblGenomes-Gn:BSU35160" /db_xref="EnsemblGenomes-Tr:CAB15533" /db_xref="GOA:O34863" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004602" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12697" /db_xref="UniProtKB/Swiss-Prot:O34863" /translation="MAMDRIEVKGARAHNLKNIDVTIPRDQLVVVTGLSGSGKSSLAF DTIYAEGQRRYVESLSAYARQFLGQMDKPDVDAIEGLSPAISIDQKTTSRNPRSTVGT VTEIYDYLRLLYARVGKPHCPEHGIEITSQTIEQMVDRILEYPERTKLQVLAPIVSGR KGAHVKVLEQIRKQGYVRVRIDGEMAELSDDIELEKNKKHSIEVVIDRIVVKEGVAAR LSDSLETALRLGEGRVMIDVIGEEELMFSEHHACPHCGFSIGELEPRLFSFNSPFGAC PTCDGLGMKLEVDADLVIPNQDLSLKENAVAPWTPISSQYYPQLLEAVCTHYGIDMDV PVKDLPKHQLDKVLYGSGDDLIYFRYENDFGQIREGEIQFEGVLRNIERRYKETGSDF IREQMEQYMSQKSCPTCKGYRLKKEALAVLIDGRHIGKITELSVADALAFFKDLTLSE KDMQIANLILREIVERLSFLDKVGLDYLTLSRAAGTLSGGEAQRIRLATQIGSRLSGV LYILDEPSIGLHQRDNDRLISALKNMRDLGNTLIVVEHDEDTMMAADYLIDIGPGAGI HGGQVISAGTPEEVMEDPNSLTGSYLSGKKFIPLPPERRKPDGRYIEIKGASENNLKK VNAKFPLGTFTAVTGVSGSGKSTLVNEILHKALAQKLHKAKAKPGSHKEIKGLDHLDK VIDIDQAPIGRTPRSNPATYTGVFDDIRDVFAQTNEAKVRGYKKGRFSFNVKGGRCEA CRGDGIIKIEMHFLPDVYVPCEVCHGKRYNRETLEVTYKGKSISDVLDMTVEDALSFF ENIPKIKRKLQTLYDVGLGYITLGQPATTLSGGEAQRVKLASELHKRSTGRTLYILDE PTTGLHVDDIARLLVVLQRLVDNGDTVLVIEHNLDIIKTADYIVDLGPEGGAGGGTIV ASGTPEEITEVEESYTGRYLKPVIERDKTRMKSLLKAKETATS*" gene complement(3430571..3433444) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" downshifts complement(3430588) /Source="Nicolas_upshifts" /id="D1819" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="4.46283" /MaxDrop="5.3695" /score="12.0157254" /energy="-18.6" /TU="U2754,U2756" /idTUdmin="U2755" /TUdmin=0 /isTUend="TRUE" CDS complement(3433452..3435437) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit B)" /protein_id="NP_391397.1" /db_xref="EnsemblGenomes-Gn:BSU35170" /db_xref="EnsemblGenomes-Tr:CAB15534" /db_xref="GOA:P37954" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004807" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR024759" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036876" /db_xref="PDB:2D7D" /db_xref="PDB:2NMV" /db_xref="PDB:3V4R" /db_xref="SubtiList:BG10502" /db_xref="UniProtKB/Swiss-Prot:P37954" /translation="MKDRFELVSKYQPQGDQPKAIEKLVKGIQEGKKHQTLLGATGTG KTFTVSNLIKEVNKPTLVIAHNKTLAGQLYSEFKEFFPNNAVEYFVSYYDYYQPEAYV PQTDTFIEKDASINDEIDKLRHSATSALFERRDVIIIASVSCIYGLGSPEEYREMVVS LRTEMEIERNELLRKLVDIQYARNDIDFQRGTFRVRGDVVEIFPASRDEHCVRVEFFG DEIERIREVDALTGEILGDRDHVAIFPASHFVTRAEKMEKAIQNIEKELEEQLKVMHE NGKLLEAQRLEQRTRYDLEMMREMGFCSGIENYSRHLTLRPPGSTPYTLLDYFPDDFM IVVDESHVTIPQVRGMFNGDQARKQVLVDHGFRLPSALDNRPLRFEEFEKHMHNIVYV SATPGPYEIEHTDEMVEQIIRPTGLLDPLIDVRPIEGQIDDLIGEIQARIERNERVLV TTLTKKMSEDLTDYLKEIGIKVNYLHSEIKTLERIEIIRDLRLGKYDVLVGINLLREG LDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNAEGRVIMYADKITKSMEIAINE TKRRREQQERFNEEHGITPKTINKEIRDVIRATVAAEDKAEYKTKAAPKLSKMTKKER QKVVEQMEHEMKEAAKALDFERAAELRDLLLELKAEG*" gene complement(3433452..3435437) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" promotor_-10 complement(3435471..3435490) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3435483) /Source="Nicolas_upshifts" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" S_feature complement(3435485..3435570) /Source="Nicolas_S_feature" /locus_tag="new_3614978_3615063_c" /HighExp="Gly, Sw, B60, BT, LoTm, Salt, Etha, M9-stat, B36, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1342" promotor_-35 complement(3435502..3435509) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3435615) /Source="Nicolas_upshifts" /id="D1820" /incds=0 /nref=4 /ntot=60 /MaxReadThrough="5.68784" /MaxDrop="3.17938" /score="11.285993" /energy="-12" /TU="U2755,U2756" /idTUdmin="U2755" /TUdmin="-5027" /isTUend="FALSE" CDS complement(3435623..3435853) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 1592822, 1744042; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_391398.1" /db_xref="EnsemblGenomes-Gn:BSU35180" /db_xref="EnsemblGenomes-Tr:CAB15535" /db_xref="GOA:P37953" /db_xref="InterPro:IPR019242" /db_xref="SubtiList:BG10501" /db_xref="UniProtKB/Swiss-Prot:P37953" /translation="MITKAVFALFFPFMLVVLFTRVTFNHYVAIALTAALLFASYLKG YTETYFIVGLDVVSLVAGGLYMAKKAAEKKEE*" gene complement(3435623..3435853) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" promotor_-10 complement(3435880..3435899) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-10" upshifts complement(3435890) /Source="Nicolas_upshifts" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" S_feature complement(3435892..3435956) /Source="Nicolas_S_feature" /locus_tag="new_3615385_3615449_c" /HighExp="Gly, M9-stat, B60, Sw, Etha, LoTm, BT, B36, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1343" promotor_-35 complement(3435913..3435920) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-35" promotor_-10 complement(3435933..3435951) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3435954) /Source="Nicolas_upshifts" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" promotor_-35 complement(3435966..3435972) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3436022) /Source="Nicolas_upshifts" /id="D1821" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.9693" /MaxDrop="4.37808" /score="-1.92287727" /energy="-4.2" /TU="NA" /idTUdmin="U2761" /TUdmin=4752 /isTUend="FALSE" promotor_no_box complement(3436048..3436148) /Source="Nicolas_upshift_promotors" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3436088) /Source="Nicolas_upshifts" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 3436170..3436177 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3436191..3436210 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3436208 /Source="Nicolas_upshifts" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 3436300..3438795 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" /EC_number="2.7.-.-" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25012659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_391399.1" /db_xref="EnsemblGenomes-Gn:BSU35190" /db_xref="EnsemblGenomes-Tr:CAB15536" /db_xref="GOA:O34796" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG14114" /db_xref="UniProtKB/Swiss-Prot:O34796" /translation="MYSVLFRQAEESSQLAGAKGMNLIKLTKHGLPVPDGFIIQTNAL ARFMEDNQLQETSENVEGGIISGTFSDELKDELTSSFYKLRESYRSVAVRSSSASEDL EGASFAGQYETYLNIKTEEEFLAKVKECWASFFSGRVSSYKKKMNNQIAEPLMGIVVQ GLIDSEMSGVIFSRNPVTHDDRELLISASYGLGEAVVSGNVTPDTFIVNKSSFEIQKE IGAKEIYMESAAEGIAEKETSEDMRSRFCLTDEQVIELAEITKKTEDLYGYPVDIEFG IADHQIYLLQARPITTIDQDKKAAEEKRSFMITDTDMNDFWLNMESNIEGPVSPLFSS FIVPALEYGLKKSMQKFPIGVVVDEVKLYRGHIYSKNQGGQQPPSEDCGKELFPILSE HMYDIINHTYLPFYRTLDQLAQTEHTAESALEAFQKLKAFYLTAYEEHFNIVFPQILL TNKLQAMYQDIQGESENAHFYEMLTGKMNKSLETDRCLWLFSVEVQENPNLLAIFENN KPEQLQEKLEQTDEGRHFLKNVHEFLQEYGWRSVKSHDLIEQIWVENPYFALANIQNY VRNGYHFDNEFQKTKEKREKLYNEFLESIEDPGLRTEFDRYYQWTLNSANIKDDHHFY IDAMLDAKARIFLLKIGELLAENGVIQDREDLWFLYDDEVEQALLHPVSLQEKAEKRR QIFHEYELAQAPAYLGTPTKEQLKAAEEIVGAVIEDEKNTENHIFGIAASSGIATGPV KIIRDANEFSQFAPGDVLVCKMTTPLWTSLFQDAKAIITDTGGILSHAAIIAREYGIP AVLGTRTATERLRDGDIITVDGSSGKITVVSRS*" gene 3436300..3438795 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" misc_feature 3438810..3438814 /Source="Nicolas_upshift_promotors" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3438828 /Source="Nicolas_upshifts" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" CDS 3438871..3439440 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391400.1" /db_xref="EnsemblGenomes-Gn:BSU35200" /db_xref="EnsemblGenomes-Tr:CAB15537" /db_xref="GOA:O34643" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG14113" /db_xref="UniProtKB/Swiss-Prot:O34643" /translation="MRPTNKRILDAAMQLLVKKGYRATTTKEIAEKANVSEATIFRNF KNKQGLVEALLSQHSSNRGSILEQTEGDLYKDLLHIGTCLLEELEHRKDIIKISFREP AMFQDVINHVTEYPQSMKQLLVDYLKTMGEKGVIQTGNEAEHADVFMSIIFGYFIHRL HLGDRVISMPQEKMLEHSTALFVKGISAD*" gene 3438871..3439440 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" CDS 3439471..3440805 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391401.1" /db_xref="EnsemblGenomes-Gn:BSU35210" /db_xref="EnsemblGenomes-Tr:CAB15538" /db_xref="GOA:O34502" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14112" /db_xref="UniProtKB/Swiss-Prot:O34502" /translation="MSSRKEWALIVSLLLGAILVPINSTMIAVALSSISHTYNESIAS ITWVVTVYLIVMAVTQPIAGKLGDMYGNKTMYLWGVGLFLIASLGCALSPSLLLLIVF RALQAVGGALLTPNSIAIIRHVVSEKRLPKVFGFFGLGAGLGAALGPFIGSILIDSFS WHSIFWVNIPFLAIALFTALTMFPQYKENKSDAPLDIIGSLLLAGSIVSIILLTKNEA PWGYTVYSVLILLFVPLFFRREKRTQHPIIDFALFKSSTFTNANLSVLLSNLMMYAVL LIMPLFMTNQFGLNTSNSGMALSVFSIFMSASNWVGAQLHHKWGAKKIIFLSFAMMAG ANLLFLLLSSSHSVLFLMLSLILGGLASGVGLTSMQVSSLATVDPGMSGVASGIFSTF RYFGSIISSALIGLISGYHTLFMILFAVSIIGVFVSLGIKSDETARIEKNSA*" gene 3439471..3440805 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" downshifts 3440786 /Source="Nicolas_upshifts" /id="D1822" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="0.94661" /MaxDrop="3.57731" /score="21.0606505" /energy="-28.8" /TU="NA" /idTUdmin="U2759" /TUdmin=1276 /isTUend="FALSE" CDS complement(3440853..3442046) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16030230, 16850406, 18976281, 19019154, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16030230, 16850406, 18976281, 19019154, 26735940; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="topological determinant of cell division" /protein_id="NP_391402.1" /db_xref="EnsemblGenomes-Gn:BSU35220" /db_xref="EnsemblGenomes-Tr:CAB15539" /db_xref="GOA:O34375" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14111" /db_xref="UniProtKB/Swiss-Prot:O34375" /translation="MSVQWGIELLKSAGLFFLHPLFWFFIIITLAFGYVRIKRERKTF HTRIADIYDDLKFTYTKGLIPGLLLSVILGGLGISIPLGLLAIIAVITAAAAFTLRAN WMSAAYIVSVSMLIGFGLQIYQAEPFLERFPQGFAVVWPAVAVFLGLLIITEGAVAYR SAHVRTSPALVVSSRGLPIGQQLANRVWLLPLFLLVPGNGLESHLSWWPVFTVPGGSF HFLWIPYFVGFGQRVQGSLPETSIRITAKRVCILGLAVAVLGAASLLWTPLAGAAVCT ALLGRIFLSIKQRVNDNAAPFYFSKRDQGLMVLGIIPNTPAEDLELKIGEIITKVNGI PVKNVSDFYEALQHNRAYVKLEIIGLNGEIRFDQRASYEGEHHELGILFVKDDREDEA VASGS*" gene complement(3440853..3442046) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" downshifts complement(3440862) /Source="Nicolas_upshifts" /id="D1823" /incds=0 /nref=3 /ntot=85 /MaxReadThrough="3.18641" /MaxDrop="3.13207" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=66 /isTUend="FALSE" downshifts complement(3440927) /Source="Nicolas_upshifts" /id="D1824" /incds=1 /nref=94 /ntot=239 /MaxReadThrough="4.11808" /MaxDrop="4.31508" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=1 /isTUend="TRUE" S_feature complement(3442047..3442124) /Source="Nicolas_S_feature" /locus_tag="new_3621540_3621617_c" /HighExp="LBGstat, Lbstat, M0t90, Cold, M/G, GM 10, GM 25, GM 15, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1344" downshifts complement(3442050) /Source="Nicolas_upshifts" /id="D1825" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="6.36185" /MaxDrop="3.35962" /score="-9.46264764" /energy="-7.1" /TU="U2760,U2761,U2762" /idTUdmin="U2762" /TUdmin="-220" /isTUend="FALSE" CDS complement(3442125..3442463) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16030230" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16030230; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein fragment; C-terminal part of swrAA" /db_xref="GOA:O32266" /db_xref="InterPro:IPR035388" /db_xref="PSEUDO:CAB15540.1" /db_xref="SubtiList:BG14160" /db_xref="UniProtKB/Swiss-Prot:O32266" /translation="MCVKKKYYELVEQLKDRTQDVTFSATKALSLLMLFSRYLVNYTN VESVNDINEECAKHYFNYLMKNHKRLGINLTDIKRSMHLISGLLDVDVNHYLKDFSLS NVTLWMTQER*" gene complement(3442125..3442463) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /pseudo CDS complement(3442438..3442554) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein; N-terminal part of swrAA" /db_xref="PSEUDO:CAX52697.1" /translation="MLVSTPVLLLILARAYLYKENGGSQLKRASIVREKKIL*" gene complement(3442438..3442554) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /pseudo S_feature complement(3442555..3442644) /Source="Nicolas_S_feature" /locus_tag="new_3622048_3622137_c" /HighExp="LBGstat, M0t90, Cold, Lbstat, GM 25, Gly, nit, GM 15, GM 10, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1345" promotor_-10 complement(3442626..3442644) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3442644) /Source="Nicolas_upshifts" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" S_feature complement(3442646..3442726) /Source="Nicolas_S_feature" /locus_tag="new_3622139_3622219_c" /HighExp="LBGstat, Lbstat, Cold, M0t90, GM 25, nit, Gly, M/G, MG 150, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigGF" /TUshortPSig="0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1346" promotor_-35 complement(3442658..3442663) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3442712..3442730) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3442726) /Source="Nicolas_upshifts" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" promotor_-35 complement(3442744..3442751) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3442863..3444305) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14526016, 17557826, 27342562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526016, 17557826, 27342562; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="PDZ-containing carboxyl-terminal protease processing protease [Zn(II)]" /protein_id="NP_391404.1" /db_xref="EnsemblGenomes-Gn:BSU35240" /db_xref="EnsemblGenomes-Tr:CAB15541" /db_xref="GOA:O35002" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="PDB:4C2C" /db_xref="PDB:4C2D" /db_xref="PDB:4C2E" /db_xref="PDB:4C2F" /db_xref="PDB:4C2G" /db_xref="PDB:4C2H" /db_xref="SubtiList:BG14110" /db_xref="UniProtKB/Swiss-Prot:O35002" /translation="MNQKIMAVIAAGSMLFGGAGVYAGINLLEMDKPQTAAVPATAQA DSERDKAMDKIEKAYELISNEYVEKVDREKLLEGAIQGMLSTLNDPYSVYMDKQTAKQ FSDSLDSSFEGIGAEVGMEDGKIIIVSPFKKSPAEKAGLKPNDEIISINGESMAGKDL NHAVLKIRGKKGSSVSMKIQRPGTKKQLSFRIKRAEIPLETVFASEKKVQGHSVGYIA ISTFSEHTAEDFAKALRELEKKEIEGLVIDVRGNPGGYLQSVEEILKHFVTKDQPYIQ IAERNGDKKRYFSTLTHKKAYPVNVITDKGSASASEILAGALKEAGHYDVVGDTSFGK GTVQQAVPMGDGSNIKLTLYKWLTPNGNWIHKKGIEPTIAIKQPDYFSAGPLQLKEPL KVDMNNEDVKHAQVLLKGLSFDPGREDGYFSKDMKKAVMAFQDQNKLNKTGVIDTRTA ETLNQQIEKKKSDEKNDLQLQTALKSLFVN*" gene complement(3442863..3444305) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" downshifts complement(3442952) /Source="Nicolas_upshifts" /id="D1826" /incds=1 /nref=1 /ntot=30 /MaxReadThrough="3.56833" /MaxDrop="3.1636" /score="0.562448109" /energy="-11.6" /TU="U2762" /idTUdmin="U2762" /TUdmin="-1122" /isTUend="FALSE" promotor_-10 complement(3444351..3444362) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3444362) /Source="Nicolas_upshifts" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" promotor_-35 complement(3444377..3444383) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3444445..3445335) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 23855774, 23869552" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 23855774, 23869552; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-division ABC transporter" /protein_id="NP_391405.1" /db_xref="EnsemblGenomes-Gn:BSU35250" /db_xref="EnsemblGenomes-Tr:CAB15542" /db_xref="GOA:O34876" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR004513" /db_xref="SubtiList:BG12591" /db_xref="UniProtKB/Swiss-Prot:O34876" /translation="MIKILGRHLRESFKSLGRNTWMTFASISAVTVTLILVGVFLVIM LNLNNMATNAEKQVEIKVLIDLTADQKAQDKLQNDIKELKGIQSVTFSSKEKELDQLV DSFGDSGKSLTMKDQENPLNDAFVVKTTDPHDTPNVAKKIEKMDHVYKVTYGKEEVSR LFKVVGVSRNIGIALIIGLVFTAMFLISNTIKITIFARRKEIEIMKLVGATNWFIRWP FFLEGLLLGVFGSVIPIALVLSTYQYVIGWVVPKVQGSFVSLLPYNPFVFQVSLVLIA IGAVIGVWGSLTSIRKFLRV*" gene complement(3444445..3445335) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" downshifts complement(3444462) /Source="Nicolas_upshifts" /id="D1827" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="3.3693" /MaxDrop="6.15417" /score="15.3496791" /energy="-14.6" /TU="U2763" /idTUdmin="U2763" /TUdmin="-102" /isTUend="FALSE" CDS complement(3445328..3446014) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division signal transducer (ATP-binding protein)" /protein_id="NP_391406.1" /db_xref="EnsemblGenomes-Gn:BSU35260" /db_xref="EnsemblGenomes-Tr:CAB15543" /db_xref="GOA:O34814" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005286" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12590" /db_xref="UniProtKB/Swiss-Prot:O34814" /translation="MIEMKEVYKAYPNGVKALNGISVTIHPGEFVYVVGPSGAGKSTF IKMIYREEKPTKGQILINHKDLATIKEKEIPFVRRKIGVVFQDFKLLPKLTVFENVAF ALEVIGEQPSVIKKRVLEVLDLVQLKHKARQFPDQLSGGEQQRVSIARSIVNNPDVVI ADEPTGNLDPDTSWEVMKTLEEINNRGTTVVMATHNKEIVNTMKKRVIAIEDGIIVRD ESRGEYGSYD*" gene complement(3445328..3446014) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" S_feature complement(3446015..3446147) /Source="Nicolas_S_feature" /locus_tag="new_3625508_3625640_c" /HighExp="Cold, UNK1, MG-0.2, MG 15, MG-0.1, C30, MG 25, MG 10, M9-exp, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.998" /label="S1347" promotor_-10 complement(3446137..3446156) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3446147) /Source="Nicolas_upshifts" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" promotor_-35 complement(3446171..3446174) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3446248..3446586) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10473570, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10473570, 19222757; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome c551" /protein_id="NP_391407.1" /db_xref="EnsemblGenomes-Gn:BSU35270" /db_xref="EnsemblGenomes-Tr:CAB15544" /db_xref="GOA:O34594" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG12574" /db_xref="UniProtKB/Swiss-Prot:O34594" /translation="MKSKLSILMIGFALSVLLAACGSNDAKEEKTDTGSKTEATASEG EELYQQSCVGCHGKDLEGVSGPNLQEVGGKYDEHKIESIIKNGRGNMPKGLVDDNEAA VIAKWLSEKK*" gene complement(3446248..3446586) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" downshifts complement(3446249) /Source="Nicolas_upshifts" /id="D1828" /incds=0 /nref=192 /ntot=265 /MaxReadThrough="3.58546" /MaxDrop="6.88513" /score="18.0901387" /energy="-16.8" /TU="U2764" /idTUdmin="U2765" /TUdmin=3 /isTUend="TRUE" promotor_-10 complement(3446613..3446632) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(3446626) /Source="Nicolas_upshifts" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" CDS complement(3446635..3447519) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10473570, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391408.2" /db_xref="EnsemblGenomes-Gn:BSU35280" /db_xref="EnsemblGenomes-Tr:CAB15545" /db_xref="GOA:O34792" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG14109" /db_xref="UniProtKB/Swiss-Prot:O34792" /translation="MLSESIGRNGGYMMDVRNKTLWILRDYVYILIGAAITAVSFNVF LLPNKIAAGGVSGISTILQSYGFEAAYVQWIINIPLFIAGVILLGGKFGLKTLAGSVF LPLVVFLTRDIQPATHHELLAAIFGGVGIGIGIGIVYLGKGSTGGTALAAQIIHKYSG LSLGKCLAIIDGMIVVTAMIVFNIEQGLYAMLGVYVSSKTIDVVQVGFNRSKMALIIT KQEQAVKEAVLQKIDRGVTKISAVGGYTDDDRPILMCVVGQTEFTKLKQIVKQIDESA FVIVADASEVLGEGFKRA*" gene complement(3446635..3447519) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" promotor_-35 complement(3446646..3446653) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" promotor_-10 complement(3447507..3447526) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(3447528) /Source="Nicolas_upshifts" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" promotor_-35 complement(3447541..3447548) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" CDS join(complement(3448676..3448747), complement(3447646..3448674)) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" /experiment="publication(s) with functional evidences, PMID:1408743, 9696765, 9882663" /ribosomal_slippage /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1408743, 9696765, 9882663; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 2" /protein_id="NP_391409.1" /db_xref="EnsemblGenomes-Gn:BSU35290" /db_xref="EnsemblGenomes-Tr:CAB15546" /db_xref="GOA:P28367" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004374" /db_xref="InterPro:IPR005139" /db_xref="InterPro:IPR020853" /db_xref="SubtiList:BG10742" /db_xref="UniProtKB/Swiss-Prot:P28367" /translation="MELSEIRAELENMASRLADFRGSLDLESKEARIAELDEQMADPE FWNDQQKAQTVINEANGLKDYVNSYKKLNESHEELQMTHDLLKEEPDTDLQLELEKEL KSLTKEFNEFELQLLLSEPYDKNNAILELHPGAGGTESQDWGSMLLRMYTRWGERRGF KVETLDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFVS CEVMPEFNDEIDIDIRTEDIKVDTYRASGAGGQHVNTTDSAVRITHLPTNVVVTCQTE RSQIKNRERAMKMLKAKLYQRRIEEQQAELDEIRGEQKEIGWGSQIRSYVFHPYSMVK DHRTNTEMGNVQAVMDGDIDTFIDAYLRSKLS*" gene complement(3447646..3448747) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" downshifts complement(3447662) /Source="Nicolas_upshifts" /id="D1829" /incds=0 /nref=193 /ntot=257 /MaxReadThrough="2.78016" /MaxDrop="6.41678" /score="27.1588259" /energy="-9.8" /TU="NA" /idTUdmin="U2766" /TUdmin="-2" /isTUend="TRUE" S_feature complement(3448748..3448816) /Source="Nicolas_S_feature" /locus_tag="new_3628241_3628309_c" /HighExp="Etha, Sw, Cold, BC, G150, BI, dia15, Mt0, LBGtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1348" CDS complement(3448817..3451342) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="translocase binding subunit (ATPase)" /protein_id="NP_391410.1" /db_xref="EnsemblGenomes-Gn:BSU35300" /db_xref="EnsemblGenomes-Tr:CAB15547" /db_xref="GOA:P28366" /db_xref="InterPro:IPR000185" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR011115" /db_xref="InterPro:IPR011116" /db_xref="InterPro:IPR011130" /db_xref="InterPro:IPR014018" /db_xref="InterPro:IPR020937" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036266" /db_xref="InterPro:IPR036670" /db_xref="PDB:1M6N" /db_xref="PDB:1M74" /db_xref="PDB:1TF2" /db_xref="PDB:1TF5" /db_xref="PDB:2IBM" /db_xref="PDB:3DL8" /db_xref="PDB:3IQM" /db_xref="PDB:3IQY" /db_xref="PDB:3JV2" /db_xref="PDB:5EUL" /db_xref="SubtiList:BG10741" /db_xref="UniProtKB/Swiss-Prot:P28366" /translation="MLGILNKMFDPTKRTLNRYEKIANDIDAIRGDYENLSDDALKHK TIEFKERLEKGATTDDLLVEAFAVVREASRRVTGMFPFKVQLMGGVALHDGNIAEMKT GEGKTLTSTLPVYLNALTGKGVHVVTVNEYLASRDAEQMGKIFEFLGLTVGLNLNSMS KDEKREAYAADITYSTNNELGFDYLRDNMVLYKEQMVQRPLHFAVIDEVDSILIDEAR TPLIISGQAAKSTKLYVQANAFVRTLKAEKDYTYDIKTKAVQLTEEGMTKAEKAFGID NLFDVKHVALNHHINQALKAHVAMQKDVDYVVEDGQVVIVDSFTGRLMKGRRYSEGLH QAIEAKEGLEIQNESMTLATITFQNYFRMYEKLAGMTGTAKTEEEEFRNIYNMQVVTI PTNRPVVRDDRPDLIYRTMEGKFKAVAEDVAQRYMTGQPVLVGTVAVETSELISKLLK NKGIPHQVLNAKNHEREAQIIEEAGQKGAVTIATNMAGRGTDIKLGEGVKELGGLAVV GTERHESRRIDNQLRGRSGRQGDPGITQFYLSMEDELMRRFGAERTMAMLDRFGMDDS TPIQSKMVSRAVESSQKRVEGNNFDSRKQLLQYDDVLRQQREVIYKQRFEVIDSENLR EIVENMIKSSLERAIAAYTPREELPEEWKLDGLVDLINTTYLDEGALEKSDIFGKEPD EMLELIMDRIITKYNEKEEQFGKEQMREFEKVIVLRAVDSKWMDHIDAMDQLRQGIHL RAYAQTNPLREYQMEGFAMFEHMIESIEDEVAKFVMKAEIENNLEREEVVQGQTTAHQ PQEGDDNKKAKKAPVRKVVDIGRNAPCHCGSGKKYKNCCGRTE*" gene complement(3448817..3451342) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" S_feature complement(3451343..3451423) /Source="Nicolas_S_feature" /locus_tag="new_3630836_3630916_c" /HighExp="Etha, M9-stat, T0.30H, B60, dia5, Cold, dia15, Lbexp, Salt, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1349" misc_feature complement(3451413..3451432) /Source="Nicolas_upshift_promotors" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3451423) /Source="Nicolas_upshifts" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" CDS complement(3451510..3452079) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome-associated sigma 54 modulation protein;ribosome dimerisation factor" /protein_id="NP_391411.1" /db_xref="EnsemblGenomes-Gn:BSU35310" /db_xref="EnsemblGenomes-Tr:CAB15548" /db_xref="GOA:P28368" /db_xref="InterPro:IPR003489" /db_xref="InterPro:IPR032528" /db_xref="InterPro:IPR034694" /db_xref="InterPro:IPR036567" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10740" /db_xref="UniProtKB/Swiss-Prot:P28368" /translation="MNYNIRGENIEVTPALKDHVERKIGKLERYFDHSVDADVNVNLK FYNDKESKVEVTIPMTDLALRSEVHNEDMYNAIDLATNKLERQIRKHKTKVNRKFREQ GSPKYLLANGLGSDTDIAVQDDIEEEESLDIVRQKRFNLKPMDSEEAILQMNMLGHNF FVFTNAETNLTNVVYRRNDGKYGLIEPTE*" gene complement(3451510..3452079) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" downshifts complement(3451518) /Source="Nicolas_upshifts" /id="D1830" /incds=0 /nref=78 /ntot=209 /MaxReadThrough="8.66806" /MaxDrop="4.7023" /score="29.9030506" /energy="-12.2" /TU="U2768,U2769,U2770,U2773" /idTUdmin="U2773" /TUdmin="-74" /isTUend="FALSE" promotor_-35 3452046..3452052 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3452065..3452084 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3452072 /Source="Nicolas_upshifts" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3452106..3452124) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3452114) /Source="Nicolas_upshifts" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" S_feature complement(3452116..3452236) /Source="Nicolas_S_feature" /locus_tag="new_3631609_3631729_c" /HighExp="C30, M0t90, S4, Lbstat, S5, M40t90, Glucon, Gly, C90, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigD, SigD" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1350" promotor_-35 complement(3452136..3452144) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3452220..3452238) /Source="Nicolas_upshift_promotors" /id="U2769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1221 /SigmaFactorBS="tgtatggaaccctttttaatcaattaggcgtgtgtgaGGTAT TtgtttcgttcaatcaGCATATACATATACCTCCGaaccgccaataacagagcaaata c" /listShort="S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3452236) /Source="Nicolas_upshifts" /id="U2769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1221 /SigmaFactorBS="tgtatggaaccctttttaatcaattaggcgtgtgtgaGGTAT TtgtttcgttcaatcaGCATATACATATACCTCCGaaccgccaataacagagcaaata c" /listShort="S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" promotor_-35 complement(3452254..3452259) /Source="Nicolas_upshift_promotors" /id="U2769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1221 /SigmaFactorBS="tgtatggaaccctttttaatcaattaggcgtgtgtgaGGTAT TtgtttcgttcaatcaGCATATACATATACCTCCGaaccgccaataacagagcaaata c" /listShort="S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3452270..3452647) /gene="yvzG" /locus_tag="BSU_35319" /old_locus_tag="BSU35319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097791.1" /db_xref="EnsemblGenomes-Gn:BSU35319" /db_xref="EnsemblGenomes-Tr:CAX52698" /db_xref="UniProtKB/Swiss-Prot:C0H3R9" /translation="MKSIEDYTLLSAYYHLLFTIEEGLCYLIEAEENLSKTEGDRIYQ DLIQAFFYLDSTHSTLLFIMDSRCAEICVKAFDQIFAEFDQLVSFSFPSHEFCEYLKE HFLIHYRKWMLSIHQCMEPFLIN*" gene complement(3452270..3452647) /gene="yvzG" /locus_tag="BSU_35319" /old_locus_tag="BSU35319" CDS complement(3452657..3452998) /gene="fliT" /locus_tag="BSU_35320" /old_locus_tag="BSU35320" /function="16.3: Control" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16952964; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar assembly protein FliT involved in control of flagella expression" /protein_id="NP_391412.1" /db_xref="EnsemblGenomes-Gn:BSU35320" /db_xref="EnsemblGenomes-Tr:CAB15549" /db_xref="GOA:P39740" /db_xref="SubtiList:BG10923" /db_xref="UniProtKB/Swiss-Prot:P39740" /translation="MNNIDQLYTETKSMLSHIQNTPESDELLKQIEDFVATRSELIQE ISLPLSEEERKQMKLILTWDQLIVKEMERLKQSIATELQQMKRKRVMHTTYLNPYNNI TIDGTYYDKRK*" gene complement(3452657..3452998) /gene="fliT" /locus_tag="BSU_35320" /old_locus_tag="BSU35320" CDS complement(3452995..3453396) /gene="fliS" /locus_tag="BSU_35330" /old_locus_tag="BSU35330" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16806204, 16936039, 20534509, 23144244, 23874669; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar assembly protein FliS" /protein_id="NP_391413.1" /db_xref="EnsemblGenomes-Gn:BSU35330" /db_xref="EnsemblGenomes-Tr:CAB15550" /db_xref="GOA:P39739" /db_xref="InterPro:IPR003713" /db_xref="InterPro:IPR036584" /db_xref="PDB:1VH6" /db_xref="SubtiList:BG10922" /db_xref="UniProtKB/Swiss-Prot:P39739" /translation="MAIQNPYTAYQQNSVNTATPGELTLMLYNGCLKFIRLAAQAIEN DDMERKNENLIKAQNIIQELNFTLNRNIELSASMGAMYDYMYRRLVQANIKNDTGMLA EVEGYVTDFRDAWKQAIQSERKDRHGSGGIA*" gene complement(3452995..3453396) /gene="fliS" /locus_tag="BSU_35330" /old_locus_tag="BSU35330" CDS complement(3453418..3454914) /gene="fliD" /locus_tag="BSU_35340" /old_locus_tag="BSU35340" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9648743, 12354229, 24296669, 25355936; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar hook-associated capping protein 2 (HAP2)" /protein_id="NP_391414.1" /db_xref="EnsemblGenomes-Gn:BSU35340" /db_xref="EnsemblGenomes-Tr:CAB15551" /db_xref="GOA:P39738" /db_xref="InterPro:IPR003481" /db_xref="InterPro:IPR010809" /db_xref="InterPro:IPR010810" /db_xref="SubtiList:BG10921" /db_xref="UniProtKB/Swiss-Prot:P39738" /translation="MVTRITGLASGMDIDDIVSKLMQTERAPLDKLTQKKQTLEWQRD SYREVNSKIKELQDYMSKNTLTYPSTYQSKTVTSSNESVLTATGSVSAPNSSSTVEVA SLATAATYKANNYTGYTQGDYNLAFNVVAPGETTAKTVNISVTSADTIDNVISKLNSS DLGVSAFKDKIWNGTEYVETIAFSSKATGAGGSIQAADSATADFMSGQLGFSLDADNK LTAYKEGTNAKVTINGFEMEKLTNNFTVNGVTYSIKNTTAATGPVTTSVSTDVDGIYN QIKEFVDKYNELVDSLNEKLKEEKYRDYTPLTSEQKEAMSDKEVELWEEKAKSGLLRN DSSISTGTNQMRTDFYTQVNADGKTYQLTEFGITTSSAYQLRGHLEINEEKLKAKIAE DPQGVANLFTSGTNDSNYSDKGIMKRITNTLRSTVKSIEAKAGNSTMGASSYSIGKNL NSISTEITDMQDRLNTIENRYYSKFSAMDSAIQKMNEQASYLSQLLVQ*" gene complement(3453418..3454914) /gene="fliD" /locus_tag="BSU_35340" /old_locus_tag="BSU35340" CDS complement(3454932..3455261) /gene="yvyC" /locus_tag="BSU_35350" /old_locus_tag="BSU35350" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 19455708; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative flagellar protein of unknown function" /protein_id="NP_391415.1" /db_xref="EnsemblGenomes-Gn:BSU35350" /db_xref="EnsemblGenomes-Tr:CAB15552" /db_xref="InterPro:IPR005186" /db_xref="InterPro:IPR035924" /db_xref="PDB:2HC5" /db_xref="SubtiList:BG10920" /db_xref="UniProtKB/Swiss-Prot:P39737" /translation="MNIERLTTLQPVWDRYDTQIHNQKDNDNEVPVHQVSYTNLAEMV GEMNKLLEPSQVHLKFELHDKLNEYYVKVIEDSTNEVIREIPPKRWLDFYAAMTEFLG LFVDEKK*" gene complement(3454932..3455261) /gene="yvyC" /locus_tag="BSU_35350" /old_locus_tag="BSU35350" downshifts 3455258 /Source="Nicolas_upshifts" /id="D1831" /incds=0 /nref=33 /ntot=140 /MaxReadThrough="2.74277" /MaxDrop="4.24086" /score="8.30527041" /energy="-10.1" /TU="NA" /idTUdmin="U2774" /TUdmin="-3062" /isTUend="FALSE" promotor_-10 complement(3455283..3455301) /Source="Nicolas_upshift_promotors" /id="U2770" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2807 /SigmaFactorBS="agaaatctaaaacagaagatttttttccaaaaatatGTGTAA TCttatctcgacttaGTCGATATAAACGATAGATtggggcataggggatgatcaattg a" /listShort="yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3455298) /Source="Nicolas_upshifts" /id="U2770" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2807 /SigmaFactorBS="agaaatctaaaacagaagatttttttccaaaaatatGTGTAA TCttatctcgacttaGTCGATATAAACGATAGATtggggcataggggatgatcaattg a" /listShort="yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" S_feature complement(3455300..3455404) /Source="Nicolas_S_feature" /locus_tag="new_3634793_3634897_c" /HighExp="Lbstat, Cold, Gly, S0, Glu, Pyr, M/G, M0t90, C30, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1351" promotor_-35 complement(3455315..3455322) /Source="Nicolas_upshift_promotors" /id="U2770" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2807 /SigmaFactorBS="agaaatctaaaacagaagatttttttccaaaaatatGTGTAA TCttatctcgacttaGTCGATATAAACGATAGATtggggcataggggatgatcaattg a" /listShort="yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3455393..3455412) /Source="Nicolas_upshift_promotors" /id="U2771" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2693 /SigmaFactorBS="tcttttaatttaaatttctatctcctaatcattcctcatcct gtcactaactCATGATATAATAACCGGATTctccactaactttttataaatgtatttc c" /listShort="S1351, yvyC, fliD, fliS, fliT, yvzG" /listLong="S1350, yvyD, S1349, secA, S1348, prfB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3455404) /Source="Nicolas_upshifts" /id="U2771" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2693 /SigmaFactorBS="tcttttaatttaaatttctatctcctaatcattcctcatcct gtcactaactCATGATATAATAACCGGATTctccactaactttttataaatgtatttc c" /listShort="S1351, yvyC, fliD, fliS, fliT, yvzG" /listLong="S1350, yvyD, S1349, secA, S1348, prfB" CDS complement(3455494..3456408) /gene="hag" /locus_tag="BSU_35360" /old_locus_tag="BSU35360" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8045886, 9648743, 12730172, 14762011, 15342569, 22720735, 25355936, 28800172, 29124898" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045886, 9648743, 12730172, 14762011, 15342569, 22720735, 25355936, 28800172, 29124898; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellin protein" /protein_id="NP_391416.1" /db_xref="EnsemblGenomes-Gn:BSU35360" /db_xref="EnsemblGenomes-Tr:CAB15553" /db_xref="GOA:P02968" /db_xref="InterPro:IPR001029" /db_xref="InterPro:IPR001492" /db_xref="SubtiList:BG10655" /db_xref="UniProtKB/Swiss-Prot:P02968" /translation="MRINHNIAALNTLNRLSSNNSASQKNMEKLSSGLRINRAGDDAA GLAISEKMRGQIRGLEMASKNSQDGISLIQTAEGALTETHAILQRVRELVVQAGNTGT QDKATDLQSIQDEISALTDEIDGISNRTEFNGKKLLDGTYKVDTATPANQKNLVFQIG ANATQQISVNIEDMGADALGIKEADGSIAALHSVNDLDVTKFADNAADTADIGFDAQL KVVDEAINQVSSQRAKLGAVQNRLEHTINNLSASGENLTAAESRIRDVDMAKEMSEFT KNNILSQASQAMLAQANQQPQNVLQLLR*" gene complement(3455494..3456408) /gene="hag" /locus_tag="BSU_35360" /old_locus_tag="BSU35360" downshifts complement(3455514) /Source="Nicolas_upshifts" /id="D1832" /incds=0 /nref=165 /ntot=233 /MaxReadThrough="5.58531" /MaxDrop="7.10921" /score="11.6997504" /energy="-13.1" /TU="U2773" /idTUdmin="U2775" /TUdmin=1078 /isTUend="FALSE" S_feature complement(3456409..3456517) /Source="Nicolas_S_feature" /locus_tag="new_3635902_3636010_c" /HighExp="T2.0H, Glucon, M0t90, T2.30H, GM 15, T-0.40H, GM 10, T1.0H, T-1.10H, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1352" promotor_-35 3456475..3456476 /Source="Nicolas_upshift_promotors" /id="U2772" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=717 /SigmaFactorBS="gttaaggcacgtccttgtgcccttattttgtaactggctgaG TcttttgcgCCTCCTCCCGGCTACatcattaatatcggattgtctctgattttgttaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3456485..3456499 /Source="Nicolas_upshift_promotors" /id="U2772" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=717 /SigmaFactorBS="gttaaggcacgtccttgtgcccttattttgtaactggctgaG TcttttgcgCCTCCTCCCGGCTACatcattaatatcggattgtctctgattttgttaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3456494 /Source="Nicolas_upshifts" /id="U2772" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=717 /SigmaFactorBS="gttaaggcacgtccttgtgcccttattttgtaactggctgaG TcttttgcgCCTCCTCCCGGCTACatcattaatatcggattgtctctgattttgttaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3456496..3456514) /Source="Nicolas_upshift_promotors" /id="U2773" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2833 /SigmaFactorBS="cgcattatcctcacaaaaaaagtgaggatttttttatttttg tATTAACAAaatcagagacaaTCCGATATTAATGATGTAGccgggaggaggcgcaaaa g" /listShort="S1352, hag, S1351, yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD" /listLong="S1349, secA, S1348, prfB" /label="promotor_-10" upshifts complement(3456517) /Source="Nicolas_upshifts" /id="U2773" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2833 /SigmaFactorBS="cgcattatcctcacaaaaaaagtgaggatttttttatttttg tATTAACAAaatcagagacaaTCCGATATTAATGATGTAGccgggaggaggcgcaaaa g" /listShort="S1352, hag, S1351, yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD" /listLong="S1349, secA, S1348, prfB" promotor_-35 complement(3456527..3456534) /Source="Nicolas_upshift_promotors" /id="U2773" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2833 /SigmaFactorBS="cgcattatcctcacaaaaaaagtgaggatttttttatttttg tATTAACAAaatcagagacaaTCCGATATTAATGATGTAGccgggaggaggcgcaaaa g" /listShort="S1352, hag, S1351, yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD" /listLong="S1349, secA, S1348, prfB" /label="promotor_-35" CDS complement(3456553..3456777) /gene="csrA" /locus_tag="BSU_35370" /old_locus_tag="BSU35370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8982093, 17555441, 21895793, 23144244, 27516547" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8982093, 17555441, 21895793, 23144244, 27516547; Product type r: regulator" /codon_start=1 /transl_table=11 /product="carbon storage regulator" /protein_id="NP_391417.1" /db_xref="EnsemblGenomes-Gn:BSU35370" /db_xref="EnsemblGenomes-Tr:CAB15554" /db_xref="GOA:P33911" /db_xref="InterPro:IPR003751" /db_xref="InterPro:IPR036107" /db_xref="PDB:1T3O" /db_xref="SubtiList:BG10654" /db_xref="UniProtKB/Swiss-Prot:P33911" /translation="MLVLSRKINEAIQIGADIEVKVIAVEGDQVKLGIDAPKHIDIHR KEIYLTIQEENNRAAALSSDVISALSSQKK*" gene complement(3456553..3456777) /gene="csrA" /locus_tag="BSU_35370" /old_locus_tag="BSU35370" downshifts complement(3456592) /Source="Nicolas_upshifts" /id="D1833" /incds=0 /nref=22 /ntot=171 /MaxReadThrough="2.28652" /MaxDrop="3.46262" /score="31.5820557" /energy="-9.2" /TU="NA" /idTUdmin="U2775" /TUdmin=0 /isTUend="TRUE" CDS complement(3456771..3457202) /gene="fliW" /locus_tag="BSU_35380" /old_locus_tag="BSU35380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15033535, 16936039, 21895793, 27516547" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15033535, 16936039, 21895793, 27516547; Product type f: factor" /codon_start=1 /transl_table=11 /product="assembly factor of the flagellum" /protein_id="NP_391418.1" /db_xref="EnsemblGenomes-Gn:BSU35380" /db_xref="EnsemblGenomes-Tr:CAB15555" /db_xref="GOA:P96503" /db_xref="InterPro:IPR003775" /db_xref="InterPro:IPR024046" /db_xref="SubtiList:BG12451" /db_xref="UniProtKB/Swiss-Prot:P96503" /translation="MIIHTKYHGQMNIKEEQIILFESGIPGFLEEKQFVILPLSEDSP FVALQSVTSENLAFIVVSPFIFFKNYEFDLDESTAELLDIDNIQDVEVMTILTMAEPF EKSTANLLAPIIVNRKNMMAKQVVLHDSSYTTKHPIGGESC*" gene complement(3456771..3457202) /gene="fliW" /locus_tag="BSU_35380" /old_locus_tag="BSU35380" CDS complement(3457223..3457798) /gene="yviE" /locus_tag="BSU_35390" /old_locus_tag="BSU35390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391419.1" /db_xref="EnsemblGenomes-Gn:BSU35390" /db_xref="EnsemblGenomes-Tr:CAB15556" /db_xref="SubtiList:BG12450" /db_xref="UniProtKB/Swiss-Prot:P96502" /translation="MQIPRLIMHSVQGKIGLTTTPASLKMEQPQADLEIEQPSAEMEI SVTPGKLTIDQTQAWEELDRKHVFKRIEEAAQQGHEDVMEGIARTAEEGDELMKIENK GNPIASQARRNSEMHQIQLGENYAPSLSRVKIQYTPSQLDVQITPRKPVIQAEPHKPI VEYTPGNVKVDMLQYPDLNIDVEYPKESPEK*" gene complement(3457223..3457798) /gene="yviE" /locus_tag="BSU_35390" /old_locus_tag="BSU35390" CDS complement(3457845..3458741) /gene="flgL" /locus_tag="BSU_35400" /old_locus_tag="BSU35400" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2407720, 15033535, 17438286, 23874669, 24296669, 24706744; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar hook-filament junction protein" /protein_id="NP_391420.1" /db_xref="EnsemblGenomes-Gn:BSU35400" /db_xref="EnsemblGenomes-Tr:CAB15557" /db_xref="GOA:P96501" /db_xref="InterPro:IPR001029" /db_xref="InterPro:IPR013384" /db_xref="SubtiList:BG11936" /db_xref="UniProtKB/Swiss-Prot:P96501" /translation="MRVTQGMIQQNSLRYIGSSYSKLDKLQSQISSGKKISKASDDPV VAMKSLKYNTQLSQVQQYKSNASQAFTWLENTETNITEGIDILSKVRELAVEAQNDTN GEPERQAIGVEVKQLKEQLLNIANTQVNGRYIFNGTNSDKPPVTDNGDGTYTISDTAD VVVNISNNMSLKVNSDPKSAFGGTSESGQNVFEMLDSFEKALNSGSLDGMDSVLNDID HFSDGMSAERSDLGARYNRLELVNTRLSAQEETATKVLSDNEDVELEEVITEFIAQQS VHRATLAVNAQIVQPTLIDFLK*" gene complement(3457845..3458741) /gene="flgL" /locus_tag="BSU_35400" /old_locus_tag="BSU35400" downshifts complement(3457868) /Source="Nicolas_upshifts" /id="D1834" /incds=0 /nref=112 /ntot=251 /MaxReadThrough="5.50861" /MaxDrop="3.8234" /score="0.376587888" /energy="-4.8" /TU="U2775,U2776,U2777" /idTUdmin="U2777" /TUdmin="-1254" /isTUend="FALSE" misc_feature 3458157..3458160 /Source="Nicolas_upshift_promotors" /id="U2774" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.97902097902098" /psig="0.000999000999001" /xcortree=54 /SigmaFactorBS="actgtccatgccatctagcgaaccagaatttagtgctttctc aaaagaatcAAGCatttcaaatacattctgcccgctttcagaagtgcctccaaaagct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3458166 /Source="Nicolas_upshifts" /id="U2774" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.97902097902098" /psig="0.000999000999001" /xcortree=54 /SigmaFactorBS="actgtccatgccatctagcgaaccagaatttagtgctttctc aaaagaatcAAGCatttcaaatacattctgcccgctttcagaagtgcctccaaaagct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3458752..3460275) /gene="flgK" /locus_tag="BSU_35410" /old_locus_tag="BSU35410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2407720, 15033535, 17438286, 23874669, 24296669, 24706744; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar hook-filament junction" /protein_id="NP_391421.1" /db_xref="EnsemblGenomes-Gn:BSU35410" /db_xref="EnsemblGenomes-Tr:CAB15558" /db_xref="GOA:P39810" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR002371" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10401" /db_xref="UniProtKB/Swiss-Prot:P39810" /translation="MTSTFMGLETARRALSAQQAALSTTANNVANANTDGYTRQRVSL EATDYFPAVSKNAEKTAGQMGTGVQGKSVERIRDIFLDYQYRLQNNSAGYYDTKAKAL SQMEGVLNETDDSGLNSVLNSFWNSLQELSNNTNEESARSVVARKGQAVAETFNYISE SLTNVQSNLKAELNTTVLDVNSLLSQLNSLNKQIAQVEPVGLLPNGLYDQRDLLIDKL SSMVDIKVSYNKSGGNALASAEGTVSIEILDKNKQSLGTVLDGKNYEVSELAANYDNE TGLVSSISIGDTAVQAESFSSKGSLLGFIESYGYITADGQEKGVYPEMLSDLDNMALE FAKAFNEVHRNGVTKSGEQGGDFFDFTGGETEPAKGAAGKIKVADSIIDSKGANIAFS LTGAANDNANATKLANVLTGKITINGKETSVLDYYAGLIGELGIEAQEANRLASNTET QLNDADINRQQMSAVSLDEEMTNMIQFQHAYNAAARMVTLQDELLDKVINGMGVGGR* " gene complement(3458752..3460275) /gene="flgK" /locus_tag="BSU_35410" /old_locus_tag="BSU35410" CDS complement(3460294..3460776) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:24706744" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24706744; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for flagellar based motility" /protein_id="NP_391422.1" /db_xref="EnsemblGenomes-Gn:BSU35420" /db_xref="EnsemblGenomes-Tr:CAB15559" /db_xref="GOA:P39808" /db_xref="InterPro:IPR007809" /db_xref="InterPro:IPR036679" /db_xref="SubtiList:BG10400" /db_xref="UniProtKB/Swiss-Prot:P39808" /translation="MSAKAIIEQLKRLCVLHEHLLTLSEEKTEALKAGKTKELSNILT KEQKYIQAITQTEDDRIKTTSAFLGYSENNTISACIAKTSGSEKEELEQLYESLSQVL GRLKKVNEMNRQLTRDALQFISISYDMLVPKENNFNYSKSIKAELPKSSKMKLFDSKA *" gene complement(3460294..3460776) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" CDS complement(3460792..3461058) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma factor repressor of sigma(D)-dependent transcription" /protein_id="NP_391423.1" /db_xref="EnsemblGenomes-Gn:BSU35430" /db_xref="EnsemblGenomes-Tr:CAB15560" /db_xref="GOA:P39809" /db_xref="InterPro:IPR007412" /db_xref="InterPro:IPR031316" /db_xref="InterPro:IPR035890" /db_xref="SubtiList:BG10399" /db_xref="UniProtKB/Swiss-Prot:P39809" /translation="MKINQFGTQSVNPYQKNYDKQAVQKTVAQPQDKIEISSQAKEMQ HASDAVTGSRQEKIAQLKAQIENGSYKVDANHIAKNMINFYKKQ*" gene complement(3460792..3461058) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" S_feature complement(3461059..3461138) /Source="Nicolas_S_feature" /locus_tag="new_3640552_3640631_c" /HighExp="T0.30H, Cold, C90, T-5.40H, T-4.40H, GM 150, T-2.40H, GM 45, S2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1353" CDS complement(3461139..3461558) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696775; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of flagella formation" /protein_id="NP_391424.1" /db_xref="EnsemblGenomes-Gn:BSU35440" /db_xref="EnsemblGenomes-Tr:CAB15561" /db_xref="GOA:P39807" /db_xref="InterPro:IPR022258" /db_xref="SubtiList:BG10398" /db_xref="UniProtKB/Swiss-Prot:P39807" /translation="MGELANCPKCNALFLKTKLQTVCQACIKEEEKSFETVYKFLRKQ ENRQSTLSRITEETGVEEELILKFIRQKRIQITHLPNLAYPCERCGTSIREGKFCKAC QSDIKDQMDHLNHEDALKIEKENSKKDTYYAYNTKNS*" gene complement(3461139..3461558) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" promotor_-10 complement(3461597..3461615) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3461608) /Source="Nicolas_upshifts" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" promotor_-35 complement(3461629..3461636) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3461632..3462354) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 28618091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the DNA transport apparatus" /protein_id="NP_391425.2" /db_xref="EnsemblGenomes-Gn:BSU35450" /db_xref="EnsemblGenomes-Tr:CAB15562" /db_xref="GOA:P39147" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005222" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10397" /db_xref="UniProtKB/Swiss-Prot:P39147" /translation="MSNEAGGGIHKLICLLCDSQFSQDVTWRALFLLKPDEKVCYSCR SKLKKITGHICPLCGRPQSVHAVCRDCEVWRTRIRDSLLLRQNRSVYTYNDMMKETLS RFKFRGDAEIINAFKSDFSSTFSKVYPDKHFVLVPIPLSKEREEERGFNQAHLLAECL DRPSHHPLIRLNNEKQSKKKKTERLLSECIFDTKNNSAEGMNIILIDDLYTTGATLHF AARCLLEKGKAASVSSFTLIRS*" gene complement(3461632..3462354) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" CDS complement(3462318..3462614) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 25423369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 25423369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of competence, pole located" /protein_id="NP_391426.1" /db_xref="EnsemblGenomes-Gn:BSU35460" /db_xref="EnsemblGenomes-Tr:CAB15563" /db_xref="GOA:P39146" /db_xref="InterPro:IPR019657" /db_xref="PDB:4WAI" /db_xref="SubtiList:BG10396" /db_xref="UniProtKB/Swiss-Prot:P39146" /translation="MLVNSKEIVMKELLDRYMDQLHMACTCQVCQNDVLALSLNKVSP SYVTDFKKIAYTKAELVDKQKNTAMLVILAESAAVVSESPSDLCQTKQEEAFIN*" gene complement(3462318..3462614) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" promotor_-10 complement(3462640..3462659) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3462653) /Source="Nicolas_upshifts" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" promotor_-35 complement(3462670..3462677) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3462674..3464065) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045895, 11359569, 12123453, 16009133, 21397556, 28559293" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045895, 11359569, 12123453, 16009133, 21397556, 28559293; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase competence protein" /protein_id="NP_391427.1" /db_xref="EnsemblGenomes-Gn:BSU35470" /db_xref="EnsemblGenomes-Tr:CAB15564" /db_xref="GOA:P39145" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10395" /db_xref="UniProtKB/Swiss-Prot:P39145" /translation="MNVPVEKNSSFSKELQQTLRSRHLLRTELSFSDEMIEWHIKNGY ITAENSISINKRRYRCNRCGQTDQRYFSFYHSSGKNKLYCRSCVMMGRVSEEVPLYSW KEENESNWKSIKLTWDGKLSSGQQKAANVLIEAISKKEELLIWAVCGAGKTEMLFPGI ESALNQGLRVCIATPRTDVVLELAPRLKAAFQGADISALYGGSDDKGRLSPLMISTTH QLLRYKDAIDVMIIDEVDAFPYSADQTLQFAVQKARKKNSTLVYLSATPPKELKRKAL NGQLHSVRIPARHHRKPLPEPRFVWCGNWKKKLNRNKIPPAVKRWIEFHVKEGRPVFL FVPSVSILEKAAACFKGVHCRTASVHAEDKHRKEKVQQFRDGQLDLLITTTILERGVT VPKVQTGVLGAESSIFTESALVQIAGRTGRHKEYADGDVIYFHFGKTKSMLDARKHIK EMNELAAKVECTD*" gene complement(3462674..3464065) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" promotor_-10 complement(3464079..3464098) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3464094) /Source="Nicolas_upshifts" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" promotor_-35 complement(3464112..3464119) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3464171..3465016) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" /EC_number="2.7.2.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid kinase fatty acid binding subunit A" /protein_id="NP_391428.1" /db_xref="EnsemblGenomes-Gn:BSU35480" /db_xref="EnsemblGenomes-Tr:CAB15565" /db_xref="GOA:P32436" /db_xref="InterPro:IPR003797" /db_xref="PDB:3FYS" /db_xref="SubtiList:BG10394" /db_xref="UniProtKB/Swiss-Prot:P32436" /translation="MNIAVVTDSTAYIPKEMREQHQIHMIPLQVVFREETYREEIELD WKSFYEEVKKHNELPTTSQPPIGELVALYEELGKSYDAVISIHLSSGISGTFSSAAAA DSMVDNIDVYPFDSEISCLAQGFYALKAAELIKNGASSPEDIIKELEEMKKTVRAYFM VDDLAHLQRGGRLSSAQAFIGSLLKVKPILHFDNKVIVPFEKIRTRKKAISRIYELLD EDASKGLPMRAAVIHANREEEAAKIIEELSAKYPHVEFYNSYFGAVIGTHLGEGALGI CWCFK*" gene complement(3464171..3465016) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" downshifts complement(3464182) /Source="Nicolas_upshifts" /id="D1835" /incds=0 /nref=207 /ntot=249 /MaxReadThrough="2.43976" /MaxDrop="5.65998" /score="25.7738948" /energy="-9.9" /TU="NA" /idTUdmin="U2779" /TUdmin=0 /isTUend="TRUE" promotor_-35 3464433..3464440 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3464454..3464473 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3464464..3466196 /Source="Nicolas_S_feature" /locus_tag="new_3643957_3645689" /HighExp="C30, S2, C90, Pyr, T0.30H, GM 150, G/S, T-4.40H, T-3.40H, T1.30H" /AntisenseName="degU" /AntisenseCor="1.0564647169900101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1354" upshifts 3464464 /Source="Nicolas_upshifts" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" promotor_-10 complement(3465043..3465062) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3465062) /Source="Nicolas_upshifts" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" promotor_-35 complement(3465077..3465080) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3465114..3465803) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_391429.1" /db_xref="EnsemblGenomes-Gn:BSU35490" /db_xref="EnsemblGenomes-Tr:CAB15566" /db_xref="GOA:P13800" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10393" /db_xref="UniProtKB/Swiss-Prot:P13800" /translation="MTKVNIVIIDDHQLFREGVKRILDFEPTFEVVAEGDDGDEAARI VEHYHPDVVIMDINMPNVNGVEATKQLVELYPESKVIILSIHDDENYVTHALKTGARG YLLKEMDADTLIEAVKVVAEGGSYLHPKVTHNLVNEFRRLATSGVSAHPQHEVYPEIR RPLHILTRRECEVLQMLADGKSNRGIGESLFISEKTVKNHVSNILQKMNVNDRTQAVV VAIKNGWVEMR*" gene complement(3465114..3465803) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" downshifts complement(3465128) /Source="Nicolas_upshifts" /id="D1836" /incds=0 /nref=178 /ntot=235 /MaxReadThrough="5.12878" /MaxDrop="6.38336" /score="20.9249268" /energy="-12.8" /TU="U2781" /idTUdmin="U2779" /TUdmin="-946" /isTUend="FALSE" S_feature complement(3465804..3465885) /Source="Nicolas_S_feature" /locus_tag="new_3645297_3645378_c" /HighExp="M40t90, Lbtran, M0t90, LBGtran, G180, T3.0H, M40t45, C90, T3.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1355" CDS complement(3465886..3467043) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" /EC_number="2.7.3.-" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [DegU]" /protein_id="NP_391430.1" /db_xref="EnsemblGenomes-Gn:BSU35500" /db_xref="EnsemblGenomes-Tr:CAB15567" /db_xref="GOA:P13799" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR008595" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR016381" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10392" /db_xref="UniProtKB/Swiss-Prot:P13799" /translation="MNKTKMDSKVLDSILMKMLKTVDGSKDEVFQIGEQSRQQYEQLV EELKQIKQQVYEVIELGDKLEVQTRHARNRLSEVSRNFHRFSEEEIRNAYEKAHKLQV ELTMIQQREKQLRERRDDLERRLLGLQEIIERSESLVSQITVVLNYLNQDLREVGLLL ADAQAKQDFGLRIIEAQEEERKRVSREIHDGPAQMLANVMMRSELIERIFRDRGAEDG FQEIKNLRQNVRNALYEVRRIIYDLRPMALDDLGLIPTLRKYLYTTEEYNGKVKIHFQ CIGETEDQRLAPQFEVALFRLAQEAVSNALKHSESEEITVKVEITKDFVILMIKDNGK GFDLKEAKEKKNKSFGLLGMKERVDLLEGTMTIDSKIGLGTFIMIKVPLSL*" gene complement(3465886..3467043) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" S_feature complement(3467044..3467171) /Source="Nicolas_S_feature" /locus_tag="new_3646537_3646664_c" /HighExp="T0.30H, Lbtran, M9-stat, T3.0H, T1.0H, HiOs, T1.30H, T2.30H, T3.30H, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1356" promotor_-35 3467091..3467094 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3467109..3467128 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3467120..3467206 /Source="Nicolas_S_feature" /locus_tag="new_3646613_3646699" /HighExp="UNK1, Cold, C30, Lbexp, MG 15, G135, G180, G150, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1357" upshifts 3467120 /Source="Nicolas_upshifts" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" promotor_-10 complement(3467165..3467184) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3467171) /Source="Nicolas_upshifts" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" promotor_-35 3467188..3467196 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3467195..3467202) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3467208 /Source="Nicolas_upshifts" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" promotor_-10 3467210..3467218 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3467260..3467913 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11116084, 15103642, 21239490, 22404850; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative translation regulator" /protein_id="NP_391431.1" /db_xref="EnsemblGenomes-Gn:BSU35510" /db_xref="EnsemblGenomes-Tr:CAB15568" /db_xref="InterPro:IPR001498" /db_xref="InterPro:IPR015269" /db_xref="InterPro:IPR015796" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020569" /db_xref="InterPro:IPR023582" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR036956" /db_xref="SubtiList:BG11052" /db_xref="UniProtKB/Swiss-Prot:P32437" /translation="MLHSYFTVKEAGEHEIVIEKSRFICHLSRVSTEQEAQEFIQKIK KQHWNATHNCSAYVIGENDHIQKANDDGEPSGTAGVPMLEVLKKRRLKDTCAVVTRYF GGIKLGAGGLIRAYGKSVSEGLNHIGVVERKLMRIMHTSADYTWLGKIENELRESQFL LKEIHYSENVEFETYVEEKETNAFSEWMTELTNGKSDIKEGELTYLEKAVNHIKETE* " gene 3467260..3467913 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" S_feature complement(3467616..3468208) /Source="Nicolas_S_feature" /locus_tag="new_3647109_3647701_c" /HighExp="Etha, M9-stat, Gly, C30, B60, Salt, T0.30H, Sw, LoTm, S8" /AntisenseName="yvyE" /AntisenseCor="-0.139956338862644" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1358" CDS 3467913..3469088 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19099556, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19099556, 29107701; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain" /protein_id="NP_391432.1" /db_xref="EnsemblGenomes-Gn:BSU35520" /db_xref="EnsemblGenomes-Tr:CAB15569" /db_xref="GOA:P96499" /db_xref="InterPro:IPR004474" /db_xref="PDB:3NXH" /db_xref="SubtiList:BG12449" /db_xref="UniProtKB/Swiss-Prot:P96499" /translation="MAERVRVRVRKKKKSKRRKILKRIMLLFALALLVVVGLGGYKLY KTINAADESYDALSRGNKSNLRNEVVDMKKKPFSILFMGIEDYATKGQKGRSDSLIVV TLDPKNKTMKMLSIPRDTRVQLAGDTTGSKTKINAAYSKGGKDETVETVENFLQIPID KYVTVDFDGFKDVINEVGGIDVDVPFDFDEKSDVDESKRIYFKKGEMHLNGEEALAYA RMRKQDKRGDFGRNDRQKQILNALIDRMSSASNIAKIDKIAEKASENVETNIRITEGL ALQQIYSGFTSKKIDTLSITGSDLYLGPNNTYYFEPDATNLEKVRKTLQEHLDYTPDT STGTSGTEDGTDSSSSSGSTGSTGTTTDGTTNGSSYSNDSSTSSNNSTTNSTTDSSY* " gene 3467913..3469088 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" promotor_-10 complement(3468204..3468222) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3468213) /Source="Nicolas_upshifts" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" promotor_-35 complement(3468236..3468242) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3469060 /Source="Nicolas_upshifts" /id="D1837" /incds=0 /nref=199 /ntot=276 /MaxReadThrough="2.38202" /MaxDrop="7.1642" /score="16.6000843" /energy="-18.6" /TU="NA" /idTUdmin="U2782" /TUdmin=4 /isTUend="TRUE" CDS complement(3469161..3470237) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" /EC_number="2.7.8.33" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine:undecaprenyl-P N-acetylglucosaminyl-1-P transferase" /protein_id="NP_391433.1" /db_xref="EnsemblGenomes-Gn:BSU35530" /db_xref="EnsemblGenomes-Tr:CAB15570" /db_xref="GOA:O34753" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG12684" /db_xref="UniProtKB/Swiss-Prot:O34753" /translation="MLDERMIRIVVAFIVSLLTVLIITPIVKRIAIKIGAVDQPSNRK VHDKIMPRMGGLAIFIGVVAGVLASGIYTETRMTAITVGAFIIIVLGILDDKYQLSAK VKFLIQLGVAIMIVSTGLKMDFFSVPFLTERFELGWMAYPLTVLWIVGITNAINLIDG LDGLAAGLSVIGLSTIAVMALSGGKVLILSLSLVVIASTLGFLFYNFHPAKIFMGDTG SLFLGYSISILSLLGLYKSVTLFSIVIPIIILGVPIFDTTFAIIRRILNKQPISAPDK SHIHHRLMAFGLSHRMSVLVIYLIGFIFSISAIVLKSATIWLSLFIIFILIIFMQIIA EVTGLVNEKFKPFTKFYKRLVKRN*" gene complement(3469161..3470237) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" downshifts complement(3469177) /Source="Nicolas_upshifts" /id="D1838" /incds=0 /nref=221 /ntot=280 /MaxReadThrough="1.7614" /MaxDrop="8.41647" /score="29.109706" /energy="-11.6" /TU="NA" /idTUdmin="U2785" /TUdmin="-1" /isTUend="TRUE" promotor_-35 3469223..3469232 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3469246..3469265 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3469254..3470487 /Source="Nicolas_S_feature" /locus_tag="new_3648747_3649980" /HighExp="S8, S6, S7, S5, BT, S4, B36, Pyr, S3, G/S" /AntisenseName="tagO" /AntisenseCor="-0.60515751332040901" /AntisenseRegPval="-27.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1359" upshifts 3469254 /Source="Nicolas_upshifts" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" S_feature complement(3470238..3470320) /Source="Nicolas_S_feature" /locus_tag="new_3649731_3649813_c" /HighExp="LPhT, Cold, LoTm, T0.30H, T3.0H, LBGstat, T1.30H, T1.0H, T2.30H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67123699999999997" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1360" promotor_-10 complement(3470308..3470327) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3470320) /Source="Nicolas_upshifts" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" promotor_-35 complement(3470339..3470345) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3470382..3471575) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391434.1" /db_xref="EnsemblGenomes-Gn:BSU35540" /db_xref="EnsemblGenomes-Tr:CAB15571" /db_xref="GOA:O32267" /db_xref="SubtiList:BG12695" /db_xref="UniProtKB/Swiss-Prot:O32267" /translation="METKEAIIHVIVATAEWGKDQLRYRRHRLAEFLAAQEETKEVIW VCPAPRAQGKEFQEVHSGIRQFAVKDLLQKKMFRFGRYTDVFYRHKLSPLLDELTPAS ANGERCCLWYTFPGFPLLSSLYSWDQVIYDCSDLWAAPISGRSNLLSEFRRKVIKSAE LRIIQRADSITCSSDYLHKEVDKKLTAGREKVHTVENGVEYELFSANKQAPDRSILQG REGIVLGFIGGIKPKLDFKMIKEAALQKPDWTFLWVGPDATNGDVSFQELLRLPNVIW TGPADPKEVPHYMELIDIGIMPYKQSPYNQAVFPLKLFEFLAAGKPVVGTNLPSTSKM QKPYVYEYVEGDHPIDFIAACEKVLGQNGDETYKEMRRNIARTQDWNCLFRQIMKYTG IQKHA*" gene complement(3470382..3471575) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" downshifts complement(3470412) /Source="Nicolas_upshifts" /id="D1839" /incds=0 /nref=23 /ntot=141 /MaxReadThrough="7.20583" /MaxDrop="4.88676" /score="4.72365619" /energy="-10.8" /TU="U2786" /idTUdmin="U2785" /TUdmin="-1236" /isTUend="FALSE" CDS complement(3471604..3472362) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391435.1" /db_xref="EnsemblGenomes-Gn:BSU35550" /db_xref="EnsemblGenomes-Tr:CAB15572" /db_xref="GOA:O32268" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12694" /db_xref="UniProtKB/Swiss-Prot:O32268" /translation="MTNWKPLVSVITPSYNARDYIEDTVHSVLDQSHPHWEMIIVDDC STDGTRDILQQYEKIDERIHVVYLEENSGAAVARNKALERAQGRYVAFLDSDDKWKKD KLEKQLEFMMERSCAFSFTGYSLMAQDGTPLDKFIHAPESLTYDDALKNTIIGCLTVM IDREQTGQIQMPNIRTRQDLATWLSLLKKGFTAYGMNECLAEYRLVNNSISSNKWKAA KKTWFVYREIERLHFMKATWCFVQYAKNAVKKRL*" gene complement(3471604..3472362) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" CDS complement(3472386..3473066) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase involved in teichuronic acid synthesis" /protein_id="NP_391436.1" /db_xref="EnsemblGenomes-Gn:BSU35560" /db_xref="EnsemblGenomes-Tr:CAB15573" /db_xref="GOA:O32269" /db_xref="InterPro:IPR003856" /db_xref="SubtiList:BG12693" /db_xref="UniProtKB/Swiss-Prot:O32269" /translation="MNDILIRIARRIKKNIIWIIAVPIILGAAGYILPSQIADQKSYT AEDTLAVGSYDHPVYNSTEEIPLLLKSDSFLKEALPDEKDEDVAEIKEKLTINTESKS LLTLSYSDEDKDRTESVLNAISSTFLKNDQKLYAEREAVIRSSIDALEGESVSEDSKV DKERFLYELKNTQLNLKAASVTDSETVSETAGGGMSPKKKAVLGVMIGLTIAFMFVVI PEFFRESF*" gene complement(3472386..3473066) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" CDS complement(3473095..3474561) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 15849754, 16850406, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative polymerase of teichuronic acid repeating units" /protein_id="NP_391437.1" /db_xref="EnsemblGenomes-Gn:BSU35570" /db_xref="EnsemblGenomes-Tr:CAB15574" /db_xref="GOA:O32270" /db_xref="InterPro:IPR007016" /db_xref="SubtiList:BG12692" /db_xref="UniProtKB/Swiss-Prot:O32270" /translation="MSIKRSAVHTLALLAAAIFGVVLLLGAIHKDIGFMQMAAVLAVL AIGLFLLTLATAFTTKERLFMAVIYILIACTFLNNAFFAIHLGFFSLFLYRLLLIAAG CLHIFGMVRNRTHIERWHGLQVKGILLFFAFWFIYGLVSLLWAKSVTVGLKYLALLAM GIFFIYLIVMYVQKMERLMIVYAIWLVMTVFLMIIGFYNHITHHHLASSTLYSGPEYK QHYPTSVFFNQNDFATFLSISFFFYITMMKNIKNGYIKAIGLVLSLCALYLIFATGSR ASLLGIFAGIAVYIFIVLPPVLKRMAIWLSAAGIALFAVLFASKIYSKFWELFLAPQT LHSFHDRLPSNVARANLLKNAWHFFLDSYGFGVGAGNVSYYLEHYAVYDTDNVAEVHN WLVEILANFGLFIMLGYLSVYAYLIWVLYKFYERKLENQSKLITEGLITAMVSFLVSS ISPSSVSNLFFHWVFMALVIAAVNVLRRSRQMPEPMYR*" gene complement(3473095..3474561) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" S_feature complement(3474562..3474645) /Source="Nicolas_S_feature" /locus_tag="new_3654055_3654138_c" /HighExp="LPhT, S3, B60, S7, S4, S6, LBGstat, BI, S8, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1361" CDS complement(3474646..3476031) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10376820, 10913081, 12970183, 16000785, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376820, 10913081, 12970183, 16000785, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 6-dehydrogenase (teichuronic acid)" /protein_id="NP_391438.1" /db_xref="EnsemblGenomes-Gn:BSU35580" /db_xref="EnsemblGenomes-Tr:CAB15575" /db_xref="GOA:O32271" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12691" /db_xref="UniProtKB/Swiss-Prot:O32271" /translation="MKKIAVIGTGYVGLVSGTCFAEIGNKVVCCDIDESKIRSLKNGV IPIYEPGLADLVEKNVLDQRLTFTNDIPSAIRASDIIYIAVGTPMSKTGEADLTYVKA AAKTIGEHLNGYKVIVNKSTVPVGTGKLVQSIVQKASKGRYSFDVVSNPEFLREGSAI HDTMNMERAVIGSTSHKAAAIIEELHQPFHAPVIKTNLESAEMIKYAANAFLATKISF INDIANICERVGADVSKVADGVGLDSRIGRKFLKAGIGFGGSCFPKDTTALLQIAKSA GYPFKLIEAVIETNEKQRVHIVDKLLTVMGSVKGRTISVLGLAFKPNTNDVRSAPALD IIPMLQQLGAHVKAYDPIAIPEASAILGEQVEYYTDVYAAMEDTDACLILTDWPEVKE MELVKVKTLLKQPVIIDGRNLFSLEEMQAAGYIYHSIGRPAVRGTEPSDKYFPGLPLE ELAKDLGSVNL*" gene complement(3474646..3476031) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" CDS complement(3476093..3477262) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391439.1" /db_xref="EnsemblGenomes-Gn:BSU35590" /db_xref="EnsemblGenomes-Tr:CAB15576" /db_xref="GOA:O32272" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG12690" /db_xref="UniProtKB/Swiss-Prot:O32272" /translation="MKILWITSVYPSSMKPGEGVFHETQVQELQKLGLDITVICPRPF HSAPVRMLKKTYRKKDVRPEYEIRKGIPVYRPFYRAVPGQLKWAQPHRRIASAVLKTM KQRDLYPDLIHAHFAMPSGGAAAVVSESAQIPYVLTLHGSDVNVYPHYSKGAFKAFKR AVGSASVVLAVSHKLQEEAKKLSGFDSSVLPIGIQLSRFQGNEETKEEIRKRLGLPLD QRLAVYVGRLVREKGIFELSEAIESLQDSPKAVFVGDGPAKSTLTQKGHIVTGQVPNH QVRDYLLAADLFVLPSYSEGMPTVVIEALALRVPVICTDVGGVSSLFGKHQHLLIKPK SAQALAEAITRYEHEQIWKPEVADDLYETVQAQFDAGKNAKALHHQYQTVTKTSV*" gene complement(3476093..3477262) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" CDS complement(3477259..3478710) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10048024, 11994144, 15849754, 16850406, 22720735, 26284661; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative exporter involved in biosynthesis of teichuronic acid" /protein_id="NP_391440.1" /db_xref="EnsemblGenomes-Gn:BSU35600" /db_xref="EnsemblGenomes-Tr:CAB15577" /db_xref="GOA:O32273" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG12689" /db_xref="UniProtKB/Swiss-Prot:O32273" /translation="MPSITKQIMSGAKWTSISTMCITIIQIVQFALLGNMMTLTEFGL VGMITTVTVFAQIVLDMGFGAALIQRDDATERQLSTLYWLNIMTGVLLFVLLYVSSPV IAGFYQREELVFLVRILAIMFLIAPIGQQYQYMLQKQLHFNTLSKIEIFSNVLSFGYL AIAVFMMDAILAYVISQVLLQSSKGILYWAVYRKKWHPAFVFDLRGMKDFFSFGAFQL SSRLVNRLGANIDMILIGRFIGAEALGIYNLAYQIVTIPVLKINPIVTRVAFPIFAKN KYENSVIREGFLNMTKMLALVSFPLLIGLVSVSDAFITAVFGEKWLAAVPILNVLAIV GILRVLMNPNGSVLLAKGRADLAFYWDSGVLLLYGLSLFAAVQTGSLLTVAWVYAIIS VVNFLIGRWLLAYVIKLNLSAYFQSIMKPFLITAAMGIIAFGVSLSTEHFSMQAEMRL AISVAAGALCYLFLLVKAYPQTKSKLLRKGRLS*" gene complement(3477259..3478710) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" CDS complement(3478766..3478915) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; C-terminal part of TuaA" /db_xref="SubtiList:BG12688" /translation="WAQVNGGYDMTPKEKLIFDLYYIRNLTFTLELKIMLKTCKVVWT GDGAR*" gene complement(3478766..3478915) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /pseudo CDS complement(3478860..3479399) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /EC_number="2.7.8.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 10048024, 11994144, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; N-terminal part of TuaA" /translation="MSAEKSMNVSREFSVQQIHSFTLSEKTARYLAIKRVMDIWFALI GLAIALPMIAVFSILICLETPGPAIYTQERVGKGGKPFKLYKLRSMKIDAEKSGAVWA QKQDPRVTRIGAFIRRTRIDELPQLFNVLKGDMSMIGPRPERPVFTEKFQNEIPGFTQ RLGSGERRLRYDAEGKADI*" gene complement(3478860..3479399) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /pseudo misc_feature complement(3479455..3479472) /Source="Nicolas_upshift_promotors" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3479459) /Source="Nicolas_upshifts" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" CDS complement(3479626..3481116) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" /EC_number="3.5.1.28" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1357079, 9537764, 14594841, 17298895, 19542270, 22469514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9537764, 14594841, 17298895, 19542270, 22469514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (major autolysin)" /protein_id="NP_391442.1" /db_xref="EnsemblGenomes-Gn:BSU35620" /db_xref="EnsemblGenomes-Tr:CAB15579" /db_xref="GOA:Q02114" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007253" /db_xref="SubtiList:BG10407" /db_xref="UniProtKB/Swiss-Prot:Q02114" /translation="MRSYIKVLTMCFLGLILFVPTALADNSVKRVGGSNRYGTAVQIS KQMYSTASTAVIVGGSSYADAISAAPLAYQKNAPLLYTNSDKLSYETKTRLKEMQTKN VIIVGGTPAVSSNTANQIKSLGISIKRIAGSNRYDTAARVAKAMGATSKAVILNGFLY ADAPAVIPYAAKNGYPILFTNKTSINSATTSVIKDKGISSTVVVGGTGSISNTVYNKL PSPTRISGSNRYELAANIVQKLNLSTSTVYVSNGFSYPDSIAGATLAAKKKQSLILTN GENLSTGARKIIGSKNMSNFMIIGNTPAVSTKVANQLKNPVVGETIFIDPGHGDQDSG AIGNGLLEKEVNLDIAKRVNTKLNASGALPVLSRSNDTFYSLQERVNKAASAQADLFL SIHANANDSSSPNGSETYYDTTYQAANSKRLAEQIQPKLAANLGTRDRGVKTAAFYVI KYSKMPSVLVETAFITNASDASKLKQAVYKDKAAQAIHDGTVSYYR*" gene complement(3479626..3481116) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" downshifts complement(3479648) /Source="Nicolas_upshifts" /id="D1840" /incds=0 /nref=145 /ntot=213 /MaxReadThrough="3.26689" /MaxDrop="6.50948" /score="13.9455176" /energy="-13.3" /TU="NA" /idTUdmin="U2788" /TUdmin=0 /isTUend="TRUE" CDS complement(3481155..3483272) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 16306698, 17269748" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 16306698, 17269748; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modifier of major autolysin amidase LytC" /protein_id="NP_391443.1" /db_xref="EnsemblGenomes-Gn:BSU35630" /db_xref="EnsemblGenomes-Tr:CAB15580" /db_xref="GOA:Q02113" /db_xref="InterPro:IPR007253" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="SubtiList:BG10406" /db_xref="UniProtKB/Swiss-Prot:Q02113" /translation="MKSCKQLIVCSLAAILLLIPSVSFAADSNISVKLLNYIGNKSSI SLSPTGFYKVTGDNVAVTDRFAGASRYETATLASNSQWKNPNTVILVNRDIFIDALPV IPLAKKLNAPVLFTQPDTLTKTTERQIAKFNPDNILIIGGARSISKDVENKLKSYGAV KRISGKNRYVLSENIAKQMGSYDKAIVVTGRVFQDALAIAPYAAAHGYPILLTEKDKL PDYDLPKQVIIIGSSFSVSDSVENQIKKTSTVQRIPGSTRYELTANIIKQLKLKADKV VMTNGTKYADVLIGASLASKKNSQILFVKQDSVPAAAKSITKDKATYAYDFIGSTSSI SAEVENSLADEFYLADGGTYNLKINSGKLNLENIKTYGNSLRIKPENYSTSNRISLDG KQYLGTVNFSIESTKYIRPVNENIPFEDYLKGVIPNEMPASWSLEALKAQTVAARTYS ITKTGTTVPDTTAFQVYGGYSWNSNTNKAVEQTKGKVLKYNGSLITAAYSSSNGGYTE ASNEVWSSSVPYLIAKKDTKDPQIGWTLTLSKQQLDTKSLDLTKPSSWWSSATETDSA RLSGVKNWILKNKETSADSVKIASIDDLSFSGTTQGQRAKTASMKVKYFVKSSTGSYN LSKITTISVPTSELRTMIGATVFKSTYVTVKKDTSKYTISGKGYGHGIGMSQYGAKAR AEAGDSYSSILKFYYPGTTLTSY*" gene complement(3481155..3483272) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" CDS complement(3483296..3483604) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1357079, 10974124, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 10974124, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="membrane bound lipoprotein" /protein_id="NP_391444.1" /db_xref="EnsemblGenomes-Gn:BSU35640" /db_xref="EnsemblGenomes-Tr:CAB15581" /db_xref="GOA:Q02112" /db_xref="SubtiList:BG10405" /db_xref="UniProtKB/Swiss-Prot:Q02112" /translation="MKKFIALLFFILLLSGCGVNSQKSQGEDVSPDSNIETKEGTYVG LADTHTIEVTVDNEPVSLDITEESTSDLDKFNSGDKVTITYEKNDEGQLLLKDIERAN *" gene complement(3483296..3483604) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" downshifts 3483510 /Source="Nicolas_upshifts" /id="D1841" /incds=1 /nref=1 /ntot=45 /MaxReadThrough="1.03108" /MaxDrop="2.46089" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2787" /TUdmin="-198" /isTUend="FALSE" promotor_-35 3483600..3483604 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3483613..3483627 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3483614..3483632) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3483620 /Source="Nicolas_upshifts" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3483646..3483653) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3483649) /Source="Nicolas_upshifts" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" promotor_-35 3483670..3483678 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3483692..3483705 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3483710 /Source="Nicolas_upshifts" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" CDS 3483788..3484708 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 9636707, 12034833, 19099556, 28197687, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9636707, 12034833, 19099556, 28197687, 29107701; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain of major autolysin expression" /protein_id="NP_391445.1" /db_xref="EnsemblGenomes-Gn:BSU35650" /db_xref="EnsemblGenomes-Tr:CAB15582" /db_xref="GOA:Q02115" /db_xref="InterPro:IPR004474" /db_xref="InterPro:IPR023734" /db_xref="SubtiList:BG10404" /db_xref="UniProtKB/Swiss-Prot:Q02115" /translation="MRNERRKKKKTLLLTILTIIGLLVLGTGGYAYYLWHKAASTVAS IHESIDKSKKRDKEVSINKKDPFSVLIMGVDERDGDKGRADTLIYMTVNPKTNTTDMV SIPRDTYTKIIGKGTMDKINHSYAFGGTQMTVDTVENFLDVPVDYFVKVNMESFRDVV DTLGGITVNSTFAFSYDGYSFGKGEITLNGKEALAYTRMRKEDPRGDFGRQDRQRQVI QGIINKGANISSITKFGDMFKVVENNVKTNLTFDNMWDIQSDYKGARKHIKQHELKGT GTKINGIYYYQADESALSDITKELKESLEK*" gene 3483788..3484708 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" downshifts 3484698 /Source="Nicolas_upshifts" /id="D1842" /incds=0 /nref=224 /ntot=261 /MaxReadThrough="0.434639999999999" /MaxDrop="6.11301" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2789" /TUdmin=0 /isTUend="TRUE" CDS complement(3484748..3485890) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" /EC_number="5.1.3.14" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12107153, 16952950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12107153, 16952950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmannosamine 2-epimerase" /protein_id="NP_391446.1" /db_xref="EnsemblGenomes-Gn:BSU35660" /db_xref="EnsemblGenomes-Tr:CAB15583" /db_xref="GOA:P39131" /db_xref="InterPro:IPR003331" /db_xref="InterPro:IPR029767" /db_xref="PDB:1O6C" /db_xref="PDB:4FKZ" /db_xref="SubtiList:BG10403" /db_xref="UniProtKB/Swiss-Prot:P39131" /translation="MKKLKVMTVFGTRPEAIKMAPLVLELKKYPEIDSYVTVTAQHRQ MLDQVLDAFHIKPDFDLNIMKERQTLAEITSNALVRLDELFKDIKPDIVLVHGDTTTT FAGSLAAFYHQIAVGHVEAGLRTGNKYSPFPEELNRQMTGAIADLHFAPTGQAKDNLL KENKKADSIFVTGNTAIDALNTTVRDGYSHPVLDQVGEDKMILLTAHRRENLGEPMEN MFKAIRRIVGEFEDVQVVYPVHLNPVVREAAHKHFGDSDRVHLIEPLEVIDFHNFAAK SHFILTDSGGVQEEAPSLGKPVLVLRDTTERPEGVEAGTLKLAGTDEENIYQLAKQLL TDPDEYKKMSQASNPYGDGEASRRIVEELLFHYGYRKEQPDSFTGK*" gene complement(3484748..3485890) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" downshifts complement(3484772) /Source="Nicolas_upshifts" /id="D1843" /incds=0 /nref=126 /ntot=236 /MaxReadThrough="0.41249" /MaxDrop="5.56107" /score="7.64930656" /energy="-11" /TU="NA" /idTUdmin="U2790" /TUdmin="-20" /isTUend="TRUE" promotor_-10 complement(3485929..3485948) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3485943) /Source="Nicolas_upshifts" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" promotor_-35 complement(3485963..3485966) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3486019..3486023 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3486039..3486058 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3486040..3486135 /Source="Nicolas_S_feature" /locus_tag="new_3665533_3665628" /HighExp="C90, dia5, Salt, Lbexp, T1.0H, MG 5, GM 90, MG 45, LoTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1362" upshifts 3486041 /Source="Nicolas_upshifts" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" CDS 3486136..3487014 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2846750, 8126437, 8320212, 9658024, 17662947, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846750, 8126437, 8320212, 9658024, 17662947, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_391447.1" /db_xref="EnsemblGenomes-Gn:BSU35670" /db_xref="EnsemblGenomes-Tr:CAB15584" /db_xref="GOA:Q05852" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10402" /db_xref="UniProtKB/Swiss-Prot:Q05852" /translation="MKKVRKAIIPAAGLGTRFLPATKAMPKEMLPIVDKPTIQYIIEE AVEAGIEDIIIVTGKSKRAIEDHFDYSPELERNLEEKGKTELLEKVKKASNLADIHYI RQKEPKGLGHAVWCARNFIGDEPFAVLLGDDIVQAETPGLRQLMDEYEKTLSSIIGVQ QVPEEETHRYGIIDPLTSEGRRYQVKNFVEKPPKGTAPSNLAILGRYVFTPEIFMYLE EQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYDVGEKLGFITTTLEFAMQDKELR DQLVPFMEGLLNKEEI*" gene 3486136..3487014 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" S_feature 3487015..3488106 /Source="Nicolas_S_feature" /locus_tag="new_3666508_3667599" /HighExp="Etha, Gly, C30, M9-stat, B60, T1.30H, B36, T1.0H, M40t90, T0.30H" /AntisenseName="yvzH" /AntisenseCor="-0.24043295548020899" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1363" S_feature complement(3487084..3487439) /Source="Nicolas_S_feature" /locus_tag="new_3666577_3666932_c" /HighExp="C30, LPh, HPh, Gly, G135, HiOs, aero, GM 25, MG 25, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.74940200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig="0.996" /label="S1364" CDS 3487348..3487566 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514004.1" /translation="MATILIPLTTLLDLSRIVGLIENHGIKPASIQTIKGTSPIPVMT SLLLRIPNTNQYAIIRIRGFKTCHNTPK*" gene 3487348..3487566 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" CDS complement(3487440..3487523) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative teichoic acid translocation permease protein tagG (fragment)" /db_xref="PSEUDO:CAX52700.1" /translation="MMAYWFVFGMRNSKLVITGIGEVPFIV*" gene complement(3487440..3487523) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /pseudo S_feature complement(3487524..3487715) /Source="Nicolas_S_feature" /locus_tag="new_3667017_3667208_c" /HighExp="HPh, LPh, C30, Gly, S0, HiOs, aero, G135, Mal, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1365" CDS complement(3487716..3490418) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16735734" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16735734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase" /protein_id="NP_391448.1" /db_xref="EnsemblGenomes-Gn:BSU35680" /db_xref="EnsemblGenomes-Tr:CAB15585" /db_xref="GOA:P46918" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR007554" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11192" /db_xref="UniProtKB/Swiss-Prot:P46918" /translation="MNEKSFNYDFSVIMPIYNVELYLTEAIESIINQTIGFENIQLIL VNDDSPDKSEIICKEYAQKYPNNIVYAKKQNGGVSSARNYGLKYAEGRYIQFLDPDDL VSEGTFENVLNFFDEHKNEIDIVAIPIFFAEGRTGEHNLNNKFSSTRILDVEKEPHHI LTHCCSTFIKKDALKNIRFDENCKIGEDAKLVNLIISQKKKYGLVKEAKYHYRVREDG SSAMQTAKANKNWFNHSLITFSKNLIDIIKNHEQKIPLFLQYMVMHDLKWKLLIKDIS ETPLDENEYSEFLTLIREVLSYIDDDVIIETKSVSHFYLYHALKIKHGENYSRYVYER ETEQDYYLYREGKIVSKLSDQTLTIEILEENEDSIHIEGFWSSLFNSKGFKFYAKIGE TKIKAKNIKRQHNDYISLGEVIKKYPGFSIDIPKGHLADNHHIEFFITKGKKRKLTKL RFFKYSGLSNDLYNTYVAKKDYIFYYNYKKLMFKKNNFKNRFIKEFRFLKSLHKSGEK SKKRKSAIKKALMARMVHHVFTIFNRKPVWLFIDRQDKADDNAEHLFKYAINKNDGVK KYFIIKKDSKDYDRIKKYGKVIPYRSFRHKILTLSSSKVISTHADIWVVNPFFNMEIY FRDLFNFEFIFLQHGITMADHSEWLNKYNKNIKLLVTSAKPEYRSIVKGNYNYKKENI LLGGFPRYDNLKKSEGEKQLLIMPTWRKDIVLPKDQAKGVRPYNPKFKDSEYFSRYNA LINDERLIEFAKKNNYKITFFPHPDIQQQIVDFEKHDYVEFADYNSSYQMLFNSSNIM ITDFSSVAFDFAYEKKPVIYYQYEKSYHFKLDYYDYKKMGFGDVLENHNSLVDKVIYY MKNNSRMEDKYRKRVDNFFAYTDKNNRNRIYNAILELDNNKVAK*" gene complement(3487716..3490418) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" S_feature complement(3490419..3490541) /Source="Nicolas_S_feature" /locus_tag="new_3669912_3670034_c" /HighExp="BMM, HiOs, MG 15, C30, SMM, GM 90, HPh, MG 150, MG 25, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1366" promotor_-35 3490440..3490446 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3490461..3490479 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3490466..3493298 /Source="Nicolas_S_feature" /locus_tag="new_3669959_3672791" /HighExp="Sw, LoTm, M9-stat, Salt, B60, T0.30H, Gly, T1.0H, B36, BI" /AntisenseName="ggaA" /AntisenseCor="-0.503651102561819" /AntisenseRegPval="-18" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1367" upshifts 3490466 /Source="Nicolas_upshifts" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" CDS complement(3490542..3491882) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16735734, 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase (missing signal peptide)" /db_xref="EnsemblGenomes-Gn:BSU35690" /db_xref="EnsemblGenomes-Tr:CAB15586" /db_xref="GOA:P46917" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PSEUDO:CAB15586.1" /db_xref="SubtiList:BG11367" /db_xref="UniProtKB/Swiss-Prot:P46917" /translation="MFSIIIPIYNSENYLRYSIESVLNQSIGFKENIELILIDDGSVD SSPQICESFKNLYPNNIKIMKIENSGPSAARNCGLSNVSERSKFIGFLDSDDAFSQNA LQSVYDFFCDSEHVNIAVLPVYYTGEKEGGHKLNNRFEKGTRVINILNDYKAIHFYIG GTFYRRHTLTSTVLFDESIKFWEDAIFFNQLLLKEKRYGAVAEGKYFYRKRKEQDSLV DRSWFNKKRYTYLLNECYMTLLMDSFNKYDIVLPYLQFLIVYHIKLFLYPNYRDVYKS VLDQQEQRVFVDDFIKVLKFIDPQFIKEQDMPMYYKEFMFHLLKENTEALENIKKERV LHSSCTVTSAKIKGLRLELTGHFINQYYEMKENDRIYIKYFKRLKKCKRKELKKTIEV WGYKLRDFRYAGFVVEIPIWAFAFDFVLKTPNDSLELNHVNIFKSLLTRVFKKR*" gene complement(3490542..3491882) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /pseudo CDS complement(3491923..3492129) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /EC_number="2.7.8.12" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase (fragment)" /db_xref="PSEUDO:CAX52701.1" /translation="MYDLPAYRDCIRGFYFNFQQKTPGNLLQTSEELIDTVKELLHNP YIDHNYEDFYNKFCNLEEARLLKE*" gene complement(3491923..3492129) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /pseudo S_feature complement(3492130..3493003) /Source="Nicolas_S_feature" /locus_tag="new_3671623_3672496_c" /HighExp="HiOs, Heat, BMM, MG 15, GM 90, MG 25, MG 150, C30, GM 25, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99943499999999996" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1368" promotor_-10 complement(3492997..3493016) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3493003) /Source="Nicolas_upshifts" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" S_feature complement(3493005..3493244) /Source="Nicolas_S_feature" /locus_tag="new_3672498_3672737_c" /HighExp="Cold, LBGstat, C30, GM 25, GM 15, GM 45, GM 60, GM 10, GM-0.2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1369" promotor_-35 complement(3493029..3493035) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3493226..3493244) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-10" upshifts complement(3493244) /Source="Nicolas_upshifts" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" promotor_-35 complement(3493258..3493265) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-35" promotor_-35 3493267..3493274 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3493286..3493305 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3493300..3493430 /Source="Nicolas_S_feature" /locus_tag="new_3672793_3672923" /HighExp="Sw, T0.30H, LoTm, B60, T1.0H, Lbtran, C30, LBGtran, dia5, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1370" upshifts 3493300 /Source="Nicolas_upshifts" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" promotor_no_box 3493372..3493472 /Source="Nicolas_upshift_promotors" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3493432 /Source="Nicolas_upshifts" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" CDS 3493436..3494032 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /EC_number="2.7.7.9" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase (UDP-glucose pyrophosphorylase) (UDPGP) (fragment)" /db_xref="PSEUDO:CAX52702.1" /translation="MISFFHYILQKEPKGLGHAVWFAPNFIGDEPFAFLLGDDIVQAD TPGLRQLTDEYERTLSSIIGVQQVPEDETHCYGIIAPLTSEGRRYQVKNFIEKPPKDT APSNLAILGRYVFTPEIFMYLEEQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYD VGEKLGFITTTLEFAMQDKELRDQLVPFMEGLLNKEEI*" gene 3493436..3494032 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /pseudo downshifts 3493630 /Source="Nicolas_upshifts" /id="D1844" /incds=1 /nref=94 /ntot=183 /MaxReadThrough="4.62614" /MaxDrop="5.15039" /score="34.2325445" /energy="-14.3" /TU="U2792,U2795" /idTUdmin="U2796" /TUdmin=0 /isTUend="TRUE" CDS complement(3494071..3495654) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" /EC_number="3.6.3.40" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 17012386, 18156271; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding teichoic acid precursor transporter component" /protein_id="NP_391451.1" /db_xref="EnsemblGenomes-Gn:BSU35700" /db_xref="EnsemblGenomes-Tr:CAB15587" /db_xref="GOA:P42954" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015860" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030284" /db_xref="SubtiList:BG11191" /db_xref="UniProtKB/Swiss-Prot:P42954" /translation="MKLKVSFRNVSKQYHLYKKQSDKIKGLFFPAKDNGFFAVRNVSF DVYEGETIGFVGINGSGKSTMSNLLAKIIPPTSGEIEMNGQPSLIAIAAGLNNQLTGR DNVRLKCLMMGLTNKEIDDMYDSIVEFAEIGDFINQPVKNYSSGMKSRLGFAISVHID PDILIIDEALSVGDQTFYQKCVDRINEFKKQGKTIFFVSHSIGQIEKMCDRVAWMHYG ELRMFDETKTVVKEYKAFIDWFNKLSKKEKETYKKEQTEERKKEDPEAFARFRKKKKK PKSLANAIQIAILSILTVFMAGTMFFNAPLRTIASFGAIPQNEVKNHHGDAKGKSEER LTAINKQGFIANEKAAAYKDQGLKQKADVTLPFGTKVTVAAKGKQAAKIKFDGHSYYV KQSAVATNMKHAELHATAFTSYVSQNAASSYEYFLKFLGDSSTSIQSKLNGYTEGNKA DGRKTLNFDYEKISYVLENDKATELIFHNISPINPASLSLSDSDVLYDSSKKRFLVNT DDQVFAVDNEEHTLTLMLK*" gene complement(3494071..3495654) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" downshifts 3494114 /Source="Nicolas_upshifts" /id="D1845" /incds=0 /nref=2 /ntot=19 /MaxReadThrough="1.20059" /MaxDrop="5.25978" /score="34.2325445" /energy="-14.3" /TU="NA" /idTUdmin="U2792" /TUdmin=440 /isTUend="FALSE" CDS complement(3495674..3496501) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 15849754, 16850406, 17012386, 18156271, 27213893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="teichoic acid precursors permease" /protein_id="NP_391452.1" /db_xref="EnsemblGenomes-Gn:BSU35710" /db_xref="EnsemblGenomes-Tr:CAB15588" /db_xref="GOA:P42953" /db_xref="InterPro:IPR000412" /db_xref="InterPro:IPR013525" /db_xref="SubtiList:BG11205" /db_xref="UniProtKB/Swiss-Prot:P42953" /translation="MNDLLRILREQITSFPLILRLAAYETKSKYQMNYLGVLWQFLNP LIQMLAYWFVFGMGIRKGGPVTTGAGEVPFIIWMLAGLIPWFFISPTILDGSNSVFKR INMVAKMNFPISSLPSVAIASNLFSYMIMMVIYIIVLLVNGVFPSVHWLQYIYYFICM IAFMFSFSLFNSTISVLIRDYQFLLQAVTRLLFFLLPIFWDVNAKLGQSHPELVPVLK LNPLFYIIEGFRNSFLDGAWFFHDMKYTLYFWLFTFLLLLVGSILHMKFRDKFVDFL* " gene complement(3495674..3496501) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" S_feature complement(3496502..3496566) /Source="Nicolas_S_feature" /locus_tag="new_3675995_3676059_c" /HighExp="H2O2, LBGstat, dia15, Oxctl, LBGexp, G150, Paraq, G180, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1371" promotor_-10 complement(3496562..3496581) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3496566) /Source="Nicolas_upshifts" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" S_feature complement(3496568..3496665) /Source="Nicolas_S_feature" /locus_tag="new_3676061_3676158_c" /HighExp="G180, G135, Cold, G150, LPh, S0, Oxctl, Paraq, HPh, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1372" promotor_-35 complement(3496597..3496600) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3496666..3498906) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" /EC_number="2.7.8.12" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CDP-glycerol:polyglycerol phosphate glycero-phosphotransferase (poly(glycerol phosphate) polymerase)" /protein_id="NP_391453.1" /db_xref="EnsemblGenomes-Gn:BSU35720" /db_xref="EnsemblGenomes-Tr:CAB15589" /db_xref="GOA:P13485" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10725" /db_xref="UniProtKB/Swiss-Prot:P13485" /translation="MSLVVDTNKRKQKGKSFYTEEQKKVMIENTVIKCILKSLKNNLG SLELLISIDSEHQFLEDYQLFLKLKERRSGTESEFPLQNTGSLEYKTEINAHVLPMPV EMGQTYDFYVEFRKKYEDAEQEPLLKRLSAEVNSIERAFHVDQTTELLILPYTTDKGN FSIKVKREAKIIRFDQIEISSEEISITGYAGYLSSENQYRIKNLNLILKKGGETPIEE KFPIKLERKTHGLENMRADGFVPELYDFEVKVPLKEIPFSNEKRYVYRLFMEYICNDD EGTDIQFNSTALVLGDRKNKLKGLVSIIKTNNAPVRYEVFKKKKKQTLGIRVNDYSLK TRMKYFIKGKKKRLVSKIKKITKMRNKLITKTYKSLFMMASRMPVKRKTVIFESFNGK QYSCNPRAIYEYMRENHPEYKMYWSVNKQYSAPFDEKGIPYINRLSLKWLFAMARAEY WVVNSRLPLWIPKPSHTTYLQTWHGTPLKRLAMDMEEVHMPGTNTKKYKRNFIKEASN WDYLISPNGYSTEIFTRAFQFNKTMIESGYPRNDFLHNDNNEETISLIKSRLNIPRDK KVILYAPTWRDDQFYAKGRYKFDLDLDLHQLRQELGNEYIVILRMHYLVAENFDLGPF EGFAYDFSAYEDIRELYMVSDLLITDYSSVFFDFANLKRPMLFFVPDIETYRDKLRGF YFDFEKEAPGPLVKTTEETIEAIKQISSPDYKLPVSFGPFYDKFCYLESGRSSEKVVN TVFKAE*" gene complement(3496666..3498906) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" CDS complement(3498906..3500927) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" /EC_number="2.4.1.52" /function="16.8: Protect" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose:polyglycerol phosphate alpha-glucosyltransferase" /protein_id="NP_391454.1" /db_xref="EnsemblGenomes-Gn:BSU35730" /db_xref="EnsemblGenomes-Tr:CAB15590" /db_xref="GOA:P13484" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR015397" /db_xref="SubtiList:BG10724" /db_xref="UniProtKB/Swiss-Prot:P13484" /translation="MSLHAVSESNIKQIPDMDYYFISGGLPSNYGGLTKSLLLRSKLF GEECNQNTFFLTFRFDLELSSKIDELYSNGKIDKKFTSVINLFDDFLSVRTNGKRSYE ERIGLDQIKKQVGMGKFAKTLLRLFGKKNNEMSVVYYGDGETIRYVDYWNDKNQLIKR EEYTKNGNLVLVTHYDVQLNKMYLQEYINDQNQVYLDKLYVWNNEEKDVQLSHIIWYS LEGEIKVKDESELRQYWIEYLQKQNDKPKLFLVDSRPQDKHVFKVKKSPSSYYGAIIH NKHYGSNKYQIKGRYKEVFSQMYNLDAVFFITEEQLEDFKLISGEQETFFFTPHTIDK PLDPAVLNVPSEKYKAVIISRLASMKNLIHAVKAFSLVVKEIPEAKLDIFGSGEDFEK IKKEIEDTKLQNNVFLKGYTDNPDSEFQKAWLTISTSHFEGFGLSNMEALSNGCPVVT YDYDYGARSLVTDGANGYVIEQYNIEKLGQAIISLMKDESTHQKFSEQAFKMAEKYSR PNYIENWAFALNQMIEVRIEREKFSKKVGKKDPSISSYTEDFDKTKIEIDIENFDHND IKKIRLVGLDRKNKAEIISTNLQNDQLFVIDLEKDVNIEKIAANKTQVIDFYIVFNAN GHIKTMRRLSSEETKLSGNSIDTNNGYRVEPYTTVKGNFSWRVTEIKES*" gene complement(3498906..3500927) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" promotor_-35 3499669..3499678 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3499691..3499706 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3499702 /Source="Nicolas_upshifts" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(3500928..3501087) /Source="Nicolas_S_feature" /locus_tag="new_3680421_3680580_c" /HighExp="G180, G135, Cold, G150, Oxctl, LBGexp, Paraq, Lbexp, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1373" CDS complement(3501088..3501477) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" /EC_number="2.7.7.39" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol-3-phosphate cytidylyltransferase" /protein_id="NP_391455.1" /db_xref="EnsemblGenomes-Gn:BSU35740" /db_xref="EnsemblGenomes-Tr:CAB15591" /db_xref="GOA:P27623" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR006409" /db_xref="InterPro:IPR014729" /db_xref="PDB:1COZ" /db_xref="PDB:1N1D" /db_xref="SubtiList:BG10449" /db_xref="UniProtKB/Swiss-Prot:P27623" /translation="MKKVITYGTFDLLHWGHIKLLERAKQLGDYLVVAISTDEFNLQK QKKAYHSYEHRKLILETIRYVDEVIPEKNWEQKKQDIIDHNIDVFVMGDDWEGKFDFL KDQCEVVYLPRTEGISTTKIKEEIAGL*" gene complement(3501088..3501477) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" S_feature complement(3501478..3501612) /Source="Nicolas_S_feature" /locus_tag="new_3680971_3681105_c" /HighExp="BC, Cold, T3.0H, HiOs, MG-0.2, T1.30H, T3.30H, LPhT, MG 15, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1374" promotor_-10 complement(3501596..3501615) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3501612) /Source="Nicolas_upshifts" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" promotor_-35 complement(3501626..3501633) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3501767..3501773 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3501784..3501876 /Source="Nicolas_S_feature" /locus_tag="new_3681277_3681369" /HighExp="B60, LoTm, Cold, T3.30H, T3.0H, Salt, T5.0H, T4.0H, Lbexp, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1375" upshifts 3501784 /Source="Nicolas_upshifts" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" promotor_-10 3501785..3501804 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3501877..3502647 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" /EC_number="2.4.1.187" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmannosamine (ManNAc) C4 hydroxyl of a membrane-anchored N-acetylglucosaminyl diphospholipid (GlcNAc-pp-undecaprenyl, lipid I) glycosyltransferase" /protein_id="NP_391456.1" /db_xref="EnsemblGenomes-Gn:BSU35750" /db_xref="EnsemblGenomes-Tr:CAB15592" /db_xref="GOA:P27620" /db_xref="InterPro:IPR004629" /db_xref="InterPro:IPR034714" /db_xref="SubtiList:BG10450" /db_xref="UniProtKB/Swiss-Prot:P27620" /translation="MQTETIHNIPYVNSNLTSFIDYLEKHYIDQKIGAVISTVNPEIA FAAIKDRDYFDVLSSSNFILPDGIGVVMMSRLTNNRLQSRIAGYDVFKELLGVANKKK KRIFLYGAKKDVIKGVVSKISSEYPNIKIAGYSDGYVQDRTLVAKQIARANPDMVFVA LGYPHQEKFIHNYRHLFPKAVSIGLGGSFDVFSGNVKRAPSWMIRLNLEWFYRLILNP WRWKRMLSIPKYALTVLKEEKNKKTFYPKPEKDHTKQI*" gene 3501877..3502647 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" S_feature complement(3502004..3502352) /Source="Nicolas_S_feature" /locus_tag="new_3681497_3681845_c" /HighExp="S8, S6, S7, S5, S4, G135, S3, C30, G180, ferm" /AntisenseName="tagA" /AntisenseCor="-0.35014495927301897" /AntisenseRegPval="-8.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1376" promotor_-10 complement(3502356..3502367) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3502360) /Source="Nicolas_upshifts" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" promotor_-35 complement(3502382..3502388) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3502672 /Source="Nicolas_upshifts" /id="D1846" /incds=0 /nref=2 /ntot=103 /MaxReadThrough="6.64821" /MaxDrop="3.225" /score="-6.01444425" /energy="-10.9" /TU="U2800" /idTUdmin="U2800" /TUdmin="-2310" /isTUend="FALSE" CDS 3502680..3503825 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" /EC_number="2.7.8.44" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid primase, CDP-glycerol:N-acetyl-beta-d-mannosaminyl-1, 4-N-acetyl-d-glucosaminyldiphosphoundecaprenyl glycerophosphotransferase" /protein_id="NP_391457.1" /db_xref="EnsemblGenomes-Gn:BSU35760" /db_xref="EnsemblGenomes-Tr:CAB15593" /db_xref="GOA:P27621" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10451" /db_xref="UniProtKB/Swiss-Prot:P27621" /translation="MKIRSLLANCYLYFLSAIAFFLQWVKPESKVTLLISFEANAKAI LEEYEQGQYSYKLNILYTQQASAIAESFPNVDAYLLQEKNPIHLIKAVYLMFNSKVII TDNYFLLTSVLNKRKQTKCIQVWHANGSLKKFGLEDITNMQRTKTDIKRFQKVYSSYD YLTVGSEEMANIFKKSFGIKDNQLLKIGVPLTDPYYRENKKKISDTLNIQRKKIILYA PTFRDYNMQSIQLPFTEEQLIHQLKEEYVLFVKLHPAIQNNIDIKYSSDYIKDVSNYA LFDLLMAADILITDYSSVPFEFSILNKPILFYTYDLKLYQQKRGLVDNYLSIIPGRAC YDSESLINEIQTPFNYSKIKVFSDRWNKYSDGNSSQNLLNFIENLIS*" gene 3502680..3503825 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" downshifts 3503813 /Source="Nicolas_upshifts" /id="D1847" /incds=0 /nref=101 /ntot=235 /MaxReadThrough="3.54908" /MaxDrop="5.95551" /score="-3.22062454" /energy="-10" /TU="U2800" /idTUdmin="U2800" /TUdmin="-1169" /isTUend="FALSE" promotor_-35 3503867..3503874 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3503889..3503908 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3503899 /Source="Nicolas_upshifts" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" CDS 3503945..3505273 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7952180, 16269821; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polyglycerol phosphate assembly and export protein (teichoic acid biosynthesis)" /protein_id="NP_391458.1" /db_xref="EnsemblGenomes-Gn:BSU35770" /db_xref="EnsemblGenomes-Tr:CAB15594" /db_xref="GOA:P27622" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG10453" /db_xref="UniProtKB/Swiss-Prot:P27622" /translation="MRKKELFDFTNITPKLFTELRVADKTVLQSFNFDEKNHQIYTTQ VASGLGKDNTQSYRITRLSLEGLQLDSMLLKHGGHGTNIGIENRNGTIYIWSLYDKPN ETDKSELVCFPYKAGATLDENSKELQRFSNMPFDHRVTPALDMKNRQLAIRQYDTKNN NNKQWVTIFNLDDAIANKNNPLYTINIPDELHYLQGFFLDDGYLYWYTGDTNSKSYPN LITVFDSDNKIVLQKEITVGKDLSTRYENNFREPEGICMYTNPETGAKSLMVGITSGK EGNRISRIYAYHSYENFMNHVPMLRSPLLKTVGHQDTPPERFQPFIQTFILEYNAQNK KWMVPTSGYLPSYTSNLVRNITINADGNLQVTLNERYISLLHQSIEGDFRLKQKDIRM GSWYFAGGEKSNVLEIGFMKGSTKIRPDDAAISNASRMSIFMIVADKIEV*" gene 3503945..3505273 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" downshifts 3505268 /Source="Nicolas_upshifts" /id="D1848" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.77356" /MaxDrop="4.002" /score="-7.52215775" /energy="-19.3" /TU="NA" /idTUdmin="U2802" /TUdmin=0 /isTUend="TRUE" downshifts complement(3505329) /Source="Nicolas_upshifts" /id="D1849" /incds=0 /nref=141 /ntot=248 /MaxReadThrough="0.94732" /MaxDrop="5.40128" /score="-0.11635468" /energy="-19.3" /TU="NA" /idTUdmin="U2803" /TUdmin="-7" /isTUend="TRUE" CDS complement(3505333..3507975) /gene="lytD" /locus_tag="BSU_35780" /old_locus_tag="BSU35780" /EC_number="3.2.1.96" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9537764, 10206711, 17298895, 19542270, 22469514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9537764, 10206711, 17298895, 19542270, 22469514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported N-acetylglucosaminidase (major autolysin) (CWBP90)" /protein_id="NP_391459.1" /db_xref="EnsemblGenomes-Gn:BSU35780" /db_xref="EnsemblGenomes-Tr:CAB15595" /db_xref="GOA:P39848" /db_xref="InterPro:IPR002901" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="SubtiList:BG10455" /db_xref="UniProtKB/Swiss-Prot:P39848" /translation="MKKRLIAPMLLSAASLAFFAMSGSAQAAAYTDYSLYKVEPSNTF STESQASQAVAKLEKDTGWDASYQASGTTTTYQISASGIHSESEAKAILSGLAKQTSI TGTSSPVGSKQPYVTISSGAISGEKQANTILAKLKQETGVAGAVKAYGAAQPYMNVMT SDIADETKVKALIQSLAKQTGIKSSYQPITHTVSVTTIQSGTIVGDSRAAQIKNAFQK ESGLQASLKETVKGQAYYTFTTAAISGEANAKTLLQQLKQSTGITGSYKSINQKTTVE SYNVQSAYFKGLSTVKDAISQIKKNTGVSGSYQQVGKSTSYTVNMKGITKQQLQKIDT FFKKKKWHYTSSSVKKTTTSAAYQITTAKILGEQQANKAAAFFAQKKVKAAKTAAGST AENQYQLISEETSDQAKVTKGLNILKKNQLSASAKSVKKQIADTFKITTESLLDQTKV NQALTFFKSNHISVASQKTGQTAASSYQITTEAIISQEEIDRVLTFFKQNHIAVTTSK TGQTAYTQYKIVTTQLSSKTALNNGLTYLKSKSVTPSYTTKSNTLYKISVNEQFTGND TAAAASTKLKQLYGWTSSIVKIKNGPQIMKTNYNLSLRDMVQKQMTVSPQTDGAAYVS LTYINTATSTVTADVLNIRSTPEVSPTNVIGQFKKGDKVKVIGQINGWAKINLGWRNA SSDEVVQYVDPNNFSRDSKYYFQFLKLSQTAGLSVTEVNQKVLAGKGILTGRAKAFID AANQYSINELYLISHALLETGNGTSALANGLTYNGKTVYNMYGIGAYDSNPNYYGAKY AYEQGWFTPEAAIIGGAKFIGSSYIHNTAYNQDTLYKMRWSATATHQYATDIGWAYKQ VNRMYSLYSLLDGYTLYFDVPEYR*" gene complement(3505333..3507975) /gene="lytD" /locus_tag="BSU_35780" /old_locus_tag="BSU35780" promotor_-10 complement(3506578..3506597) /Source="Nicolas_upshift_promotors" /id="U2803" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1231 /SigmaFactorBS="gatcaaacgaaagtcaatcagGCACTCACGTttttcaaatcg aATCATATATCAGTAGCAAGCcagaaaaccggtcagacagctgcgagcagctatcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3506580) /Source="Nicolas_upshifts" /id="U2803" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1231 /SigmaFactorBS="gatcaaacgaaagtcaatcagGCACTCACGTttttcaaatcg aATCATATATCAGTAGCAAGCcagaaaaccggtcagacagctgcgagcagctatcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3506610..3506619) /Source="Nicolas_upshift_promotors" /id="U2803" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1231 /SigmaFactorBS="gatcaaacgaaagtcaatcagGCACTCACGTttttcaaatcg aATCATATATCAGTAGCAAGCcagaaaaccggtcagacagctgcgagcagctatcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3508010..3508028) /Source="Nicolas_upshift_promotors" /id="U2804" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2808 /SigmaFactorBS="tttattagaaaatggaagtgattcacCTATAAATgaagcatg cgcgtGCCGATAAATAAACTAGTTttatatactcatagaataagaaagaggagaagga a" /listShort="lytD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3508015) /Source="Nicolas_upshifts" /id="U2804" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2808 /SigmaFactorBS="tttattagaaaatggaagtgattcacCTATAAATgaagcatg cgcgtGCCGATAAATAAACTAGTTttatatactcatagaataagaaagaggagaagga a" /listShort="lytD" /GFF_Attribute="listLong" promotor_-35 complement(3508042..3508049) /Source="Nicolas_upshift_promotors" /id="U2804" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2808 /SigmaFactorBS="tttattagaaaatggaagtgattcacCTATAAATgaagcatg cgcgtGCCGATAAATAAACTAGTTttatatactcatagaataagaaagaggagaagga a" /listShort="lytD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3508104..3509054) /gene="pmiA" /locus_tag="BSU_35790" /old_locus_tag="BSU35790" /EC_number="5.3.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7581999, 10704478, 19447949, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7581999, 10704478, 19447949, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannose-6-phosphate isomerase (active on aldose substrates with hydroxyl groups oriented in the same direction at the C-2 and C-3 positions as in mannose)" /protein_id="NP_391460.1" /db_xref="EnsemblGenomes-Gn:BSU35790" /db_xref="EnsemblGenomes-Tr:CAB15596" /db_xref="GOA:P39841" /db_xref="InterPro:IPR001250" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014628" /db_xref="InterPro:IPR014710" /db_xref="PDB:1QWR" /db_xref="SubtiList:BG10454" /db_xref="UniProtKB/Swiss-Prot:P39841" /translation="MTQSPIFLTPVFKEKIWGGTALRDRFGYSIPSESTGECWAISAH PKGPSTVANGPYKGKTLIELWEEHREVFGGVEGDRFPLLTKLLDVKEDTSIKVHPDDY YAGENEEGELGKTECWYIIDCKENAEIIYGHTARSKTELVTMINSGDWEGLLRRIKIK PGDFYYVPSGTLHALCKGALVLETQQNSDATYRVYDYDRLDSNGSPRELHFAKAVNAA TVPHVDGYIDESTESRKGITIKTFVQGEYFSVYKWDINGEAEMAQDESFLICSVIEGS GLLKYEDKTCPLKKGDHFILPAQMPDFTIKGTCTLIVSHI*" gene complement(3508104..3509054) /gene="pmiA" /locus_tag="BSU_35790" /old_locus_tag="BSU35790" downshifts complement(3508116) /Source="Nicolas_upshifts" /id="D1850" /incds=0 /nref=29 /ntot=177 /MaxReadThrough="4.74566" /MaxDrop="3.72936" /score="9.64549533" /energy="-7.7" /TU="U2805" /idTUdmin="U2806" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3509079..3509097) /Source="Nicolas_upshift_promotors" /id="U2805" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=167 /SigmaFactorBS="cataggaaaaaggcagcttatacgggCGTTTGTaagaggggc gcaccGGGAAAATGATGATCAGTTatttacaggggaggggtacggatcatgacgcaat c" /listShort="yvyI, lytD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3509084) /Source="Nicolas_upshifts" /id="U2805" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=167 /SigmaFactorBS="cataggaaaaaggcagcttatacgggCGTTTGTaagaggggc gcaccGGGAAAATGATGATCAGTTatttacaggggaggggtacggatcatgacgcaat c" /listShort="yvyI, lytD" /GFF_Attribute="listLong" S_feature complement(3509086..3509222) /Source="Nicolas_S_feature" /locus_tag="new_3688579_3688715_c" /HighExp="Lbtran, S0, M40t90, T1.0H, dia0, Mt0, Lbstat, M0t90, Lbexp, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.17043900000000001" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1377" promotor_-35 complement(3509112..3509118) /Source="Nicolas_upshift_promotors" /id="U2805" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=167 /SigmaFactorBS="cataggaaaaaggcagcttatacgggCGTTTGTaagaggggc gcaccGGGAAAATGATGATCAGTTatttacaggggaggggtacggatcatgacgcaat c" /listShort="yvyI, lytD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3509196..3509215) /Source="Nicolas_upshift_promotors" /id="U2806" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.664335664335664" /psig="0.994005994005994" /xcortree=1553 /SigmaFactorBS="tattaatttgtatcaaaaaaggagaattattcttatcgagga aaaggctgaaacaaagcttcttttcgaCGTGATATAATAGATAGGAAgcgttttcttt g" /listShort="S1377, yvyI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3509224) /Source="Nicolas_upshifts" /id="U2806" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.664335664335664" /psig="0.994005994005994" /xcortree=1553 /SigmaFactorBS="tattaatttgtatcaaaaaaggagaattattcttatcgagga aaaggctgaaacaaagcttcttttcgaCGTGATATAATAGATAGGAAgcgttttcttt g" /listShort="S1377, yvyI" /GFF_Attribute="listLong" promotor_-35 3509252..3509258 /Source="Nicolas_upshift_promotors" /id="U2807" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=900 /SigmaFactorBS="cacgtcgaaaagaagctttgtttcagccttttcctcgataAG AATAAttctccttttttgATACAAATTAATaaaaaccgtcaatatgtttaagaaggag a" /listShort="gerBA, gerBB, gerBC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3509272..3509283 /Source="Nicolas_upshift_promotors" /id="U2807" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=900 /SigmaFactorBS="cacgtcgaaaagaagctttgtttcagccttttcctcgataAG AATAAttctccttttttgATACAAATTAATaaaaaccgtcaatatgtttaagaaggag a" /listShort="gerBA, gerBB, gerBC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3509272 /Source="Nicolas_upshifts" /id="U2807" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=900 /SigmaFactorBS="cacgtcgaaaagaagctttgtttcagccttttcctcgataAG AATAAttctccttttttgATACAAATTAATaaaaaccgtcaatatgtttaagaaggag a" /listShort="gerBA, gerBB, gerBC" /GFF_Attribute="listLong" CDS 3509319..3510770 /gene="gerBA" /locus_tag="BSU_35800" /old_locus_tag="BSU35800" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:3110007, 8012571, 10411756, 15774895, 22493018, 23749970, 25681191, 25790435" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110007, 8012571, 10411756, 15774895, 22493018, 23749970, 25681191, 25790435; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="component of germinant receptor B" /protein_id="NP_391461.2" /db_xref="EnsemblGenomes-Gn:BSU35800" /db_xref="EnsemblGenomes-Tr:CAB15597" /db_xref="GOA:P39569" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10640" /db_xref="UniProtKB/Swiss-Prot:P39569" /translation="MQIDSDLQNNLDTLKKTLGQNDDMMFYTFAFGDSRQKACLLYID GLTENKMLAQYVISPLQKEALAHKECSIEDLSAFFFGFHHSVVSTMKEIEQLVFSGQA ILLADGYRGGLAFDTKSVATRSLDEPSSEVVERGPKIGFIEKLRTNTALLRERTSDPN LVIKEMTLGKRTKKKIAVAYIQDIAPDYVVKEVFKRLKSVNIDNLPESGTLEQLIEDE PFSIFPTILSTERPDRVESSLLEGRVSILVDGTPFALIVPATVDEFIHSPDDYSQRWI PMSLVRLLRYSSILITIYLPGLYISLVSFHTGLLPTRMAISIAGSRLNVPFPPFVEAF IMIFTIELIREAGLRLPKPIGQTIGLIGGVVIGQAAVQAQIVSALMVIVVSVTALASF TVPSYAYNFPLRIIRIGVMISATALGMYGVIMVYLFVIGHLMRLKSFGQDYIIPIMAQ PGQDLKDTVIRIPTMFLKRRPTRNDPEDNIRQR*" gene 3509319..3510770 /gene="gerBA" /locus_tag="BSU_35800" /old_locus_tag="BSU35800" CDS 3510776..3511882 /gene="gerBB" /locus_tag="BSU_35810" /old_locus_tag="BSU35810" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16352818, 16850406, 22493018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16352818, 16850406, 22493018; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="component of germinant receptor B" /protein_id="NP_391462.2" /db_xref="EnsemblGenomes-Gn:BSU35810" /db_xref="EnsemblGenomes-Tr:CAB15598" /db_xref="GOA:P39570" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG10641" /db_xref="UniProtKB/Swiss-Prot:P39570" /translation="MRKSEHKLTFMQTLIMISSTLIGAGVLTLPRSAAETGSPSGWLM ILLQGVIFIIIVLLFLPFLQKNSGKTLFKLNSIVAGKFIGFLLNLYICLYFIGIVCFQ ARILGEVVGFFLLKNTPMAVVVFIFLAVAIYHVGGGVYSIAKVYAYIFPITLIIFMML LMFSFRLFQLDFIRPVFEGGYQSFFSLFPKTLLYFSGFEIIFYLVPFMRDPKQVKKAV ALGIATSTLFYSITLLIVIGCMTVAEAKTVTWPTISLIHALEVPGIFIERFDLFLQLT WTAQQFACMLGSFKGAHIGLTEIFHLKNKNNAWLLTAMLAATFFITMYPKDLNDVFYY GTLLGYAFLIVITIPFFVWFLSWIQKKIGRGQLQ*" gene 3510776..3511882 /gene="gerBB" /locus_tag="BSU_35810" /old_locus_tag="BSU35810" CDS 3511879..3513003 /gene="gerBC" /locus_tag="BSU_35820" /old_locus_tag="BSU35820" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16352818, 16850406, 20654628, 21685283, 22493018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16352818, 16850406, 20654628, 21685283, 22493018; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein component of the germination receptor B" /protein_id="NP_391463.1" /db_xref="EnsemblGenomes-Gn:BSU35820" /db_xref="EnsemblGenomes-Tr:CAB15599" /db_xref="GOA:P39571" /db_xref="InterPro:IPR008844" /db_xref="PDB:3N54" /db_xref="SubtiList:BG10642" /db_xref="UniProtKB/Swiss-Prot:P39571" /translation="MKTASKFSVMFFMLLALCGCWDVKDIEQLSFARGLAIDETNDHQ YKLTYQNLLPQSEDSQASGKPEFVNVTSHGKTILEAVSDVSIKDPPVYSDHLKVILLG EKLMRNQNVDQVLNHFIRDDELRRSSYLMAARGNAADVFTKGNPNQQQPMPSEKLIDL TTHSGYNGKIMIPLRIGRASVYSQNGYSYLIQAVKNEKGKAKYDGAGIIKRGSNKLVG FLSADETQTLSWVMGTIQGGVMPTTDKGHPITFEIKKSKTKIKPVIENGKPVFHISVK TKGILTEDQNPNENSFSKSYLHRLENIFEKKLERDVKQVMDKLQHEYKTDPVFLSDHI RIQHPDYWNKVKGHWDEIFSETDFKYDISFKIINFGTVGK*" gene 3511879..3513003 /gene="gerBC" /locus_tag="BSU_35820" /old_locus_tag="BSU35820" S_feature complement(3512106..3513000) /Source="Nicolas_S_feature" /locus_tag="new_3691599_3692493_c" /HighExp="Etha, Sw, Salt, Heat, S8, B36, Gly, S7, LPhT, S6" /AntisenseName="gerBC" /AntisenseCor="0.12062795031199899" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1378" downshifts 3512993 /Source="Nicolas_upshifts" /id="D1851" /incds=0 /nref=18 /ntot=72 /MaxReadThrough="0.37711" /MaxDrop="4.85405" /score="35.6875936" /energy="-14.9" /TU="NA" /idTUdmin="U2807" /TUdmin=0 /isTUend="TRUE" CDS complement(3513040..3514413) /gene="ywtG" /locus_tag="BSU_35830" /old_locus_tag="BSU35830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carbohydrate/proton transporter" /protein_id="NP_391464.2" /db_xref="EnsemblGenomes-Gn:BSU35830" /db_xref="EnsemblGenomes-Tr:CAB15600" /db_xref="GOA:C0SPB2" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12538" /db_xref="UniProtKB/Swiss-Prot:C0SPB2" /translation="MKKQSNIWLYFFGALGGALYGYDTGVISGAILFMKKELGLNAFT EGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLF RIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEA WRWMLGLAAVPSLLLLIGILFMPESPRWLFTNGEESKAKKILEKLRGTKDIDQEIHDI KEAEKQDEGGLKELFDPWVRPALIAGLGLAFLQQFIGTNTIIYYAPKTFTNVGFGNSA SILGTVGIGTVNVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLIVLALVNLFFDNTPA ASWTTVICLGVFIVVFAVSWGPVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLT YPILMEAIGISYLFLIYAAIGIMAFLFVRFKVTETKGRSLEEIEQDLRDKNGQGGAAG KQQTVGT*" gene complement(3513040..3514413) /gene="ywtG" /locus_tag="BSU_35830" /old_locus_tag="BSU35830" downshifts complement(3513045) /Source="Nicolas_upshifts" /id="D1852" /incds=0 /nref=13 /ntot=90 /MaxReadThrough="6.08746" /MaxDrop="3.99424" /score="22.7548183" /energy="-16.7" /TU="U2808" /idTUdmin="U2808" /TUdmin="-900" /isTUend="FALSE" S_feature complement(3514414..3514477) /Source="Nicolas_S_feature" /locus_tag="new_3693907_3693970_c" /HighExp="Etha, Salt, Gly, Heat, Sw, LPhT, HiTm, Diami, B60, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1379" promotor_-10 complement(3514465..3514483) /Source="Nicolas_upshift_promotors" /id="U2808" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=188 /SigmaFactorBS="atgattggaaaacttatgatcagaaaaataaaaaGGTTTAAt ggccggaaaaagaGGCTAAAAGATTTCTAAAAaaatcccacagacaatgtcattgcag c" /listShort="S1379, ywtG, S1378" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3514478) /Source="Nicolas_upshifts" /id="U2808" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=188 /SigmaFactorBS="atgattggaaaacttatgatcagaaaaataaaaaGGTTTAAt ggccggaaaaagaGGCTAAAAGATTTCTAAAAaaatcccacagacaatgtcattgcag c" /listShort="S1379, ywtG, S1378" /GFF_Attribute="listLong" promotor_-35 complement(3514498..3514504) /Source="Nicolas_upshift_promotors" /id="U2808" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=188 /SigmaFactorBS="atgattggaaaacttatgatcagaaaaataaaaaGGTTTAAt ggccggaaaaagaGGCTAAAAGATTTCTAAAAaaatcccacagacaatgtcattgcag c" /listShort="S1379, ywtG, S1378" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3514564..3514573 /Source="Nicolas_upshift_promotors" /id="U2809" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1659 /SigmaFactorBS="ttttccaatcatttacttgtatttttttcaatgtcgcCGAAA CATTTtacctgctgcgGCGTCCAATATAAGGTgattcagtacattatcgttatcaatt t" /listShort="S1380, ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3514585..3514600 /Source="Nicolas_upshift_promotors" /id="U2809" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1659 /SigmaFactorBS="ttttccaatcatttacttgtatttttttcaatgtcgcCGAAA CATTTtacctgctgcgGCGTCCAATATAAGGTgattcagtacattatcgttatcaatt t" /listShort="S1380, ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3514587..3514707 /Source="Nicolas_S_feature" /locus_tag="new_3694080_3694200" /HighExp="T-0.40H, LBGstat, T-1.10H, T0.30H, Heat, T-1.40H, T1.30H, T1.0H, T0.0H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1380" upshifts 3514587 /Source="Nicolas_upshifts" /id="U2809" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1659 /SigmaFactorBS="ttttccaatcatttacttgtatttttttcaatgtcgcCGAAA CATTTtacctgctgcgGCGTCCAATATAAGGTgattcagtacattatcgttatcaatt t" /listShort="S1380, ywtF, S1381, ywtE" /GFF_Attribute="listLong" promotor_-35 3514682..3514689 /Source="Nicolas_upshift_promotors" /id="U2810" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58041958041958" /psig="0.997002997002997" /xcortree=2249 /SigmaFactorBS="tataggaatatttatcgaaaaatgtctttcgagTAGTTGCCc catggcaaatagAATGGTACGCTTCAAATATTaaagaaacgtgaggtattgatatatg g" /listShort="ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3514703..3514722 /Source="Nicolas_upshift_promotors" /id="U2810" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58041958041958" /psig="0.997002997002997" /xcortree=2249 /SigmaFactorBS="tataggaatatttatcgaaaaatgtctttcgagTAGTTGCCc catggcaaatagAATGGTACGCTTCAAATATTaaagaaacgtgaggtattgatatatg g" /listShort="ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3514709 /Source="Nicolas_upshifts" /id="U2810" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58041958041958" /psig="0.997002997002997" /xcortree=2249 /SigmaFactorBS="tataggaatatttatcgaaaaatgtctttcgagTAGTTGCCc catggcaaatagAATGGTACGCTTCAAATATTaaagaaacgtgaggtattgatatatg g" /listShort="ywtF, S1381, ywtE" /GFF_Attribute="listLong" CDS 3514746..3515714 /gene="tagT" /locus_tag="BSU_35840" /old_locus_tag="BSU35840" /function="12: Regulatory functions" /experiment="publication(s) with functional evidences, PMID:19099556, 22432711, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19099556, 22432711, 29107701; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain of capsule synthesis" /protein_id="NP_391465.2" /db_xref="EnsemblGenomes-Gn:BSU35840" /db_xref="EnsemblGenomes-Tr:CAB15601" /db_xref="GOA:Q7WY78" /db_xref="InterPro:IPR004474" /db_xref="PDB:3MEJ" /db_xref="PDB:4DE9" /db_xref="SubtiList:BG12537" /db_xref="UniProtKB/Swiss-Prot:Q7WY78" /translation="MEERSQRRKKKRKLKKWVKVVAGLMAFLVIAAGSVGAYAFVKLN NASKEAHVSLARGEQSVKRIKEFDPGKDSFSVLLLGIDAREKNGETVDQARSDANVLV TFNRKEKTAKMLSIPRDAYVNIPGHGYDKFTHAHAYGGVDLTVKTVEEMLDIPVDYVV ESNFTAFEDVVNELNGVKVTVKSDKVIQQIKKDTKGKVVLQKGTHTLDGEEALAYVRT RKADSDLLRGQRQMEVLSAIIDKSKSLSSIPAYDDIVDTMGQNLKMNLSLKDAIGLFP FITSLKSVESIQLTGYDYEPAGVYYFKLNQQKLQEVKKELQNDLGV*" gene 3514746..3515714 /gene="tagT" /locus_tag="BSU_35840" /old_locus_tag="BSU35840" downshifts 3515699 /Source="Nicolas_upshifts" /id="D1853" /incds=0 /nref=27 /ntot=139 /MaxReadThrough="6.07699" /MaxDrop="4.78541" /score="17.3040761" /energy="-17.8" /TU="U2809,U2810" /idTUdmin="U2809" /TUdmin="-1012" /isTUend="FALSE" promotor_-35 3515758..3515765 /Source="Nicolas_upshift_promotors" /id="U2811" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.982017982017982" /xcortree=1778 /SigmaFactorBS="cgattacgccatcccgttttacatatttcctTGTTGAAAatt atcaaagtaacGTTTAGCCTTAATTTATATGgattatgtttcacaggcaagctgaaca t" /listShort="S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3515780..3515799 /Source="Nicolas_upshift_promotors" /id="U2811" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.982017982017982" /xcortree=1778 /SigmaFactorBS="cgattacgccatcccgttttacatatttcctTGTTGAAAatt atcaaagtaacGTTTAGCCTTAATTTATATGgattatgtttcacaggcaagctgaaca t" /listShort="S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3515787..3515869 /Source="Nicolas_S_feature" /locus_tag="new_3695280_3695362" /HighExp="Etha, dia5, Lbtran, dia15, LBGexp, LBGtran, G150, Mt0, G180, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="0.982, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1381" upshifts 3515787 /Source="Nicolas_upshifts" /id="U2811" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.982017982017982" /xcortree=1778 /SigmaFactorBS="cgattacgccatcccgttttacatatttcctTGTTGAAAatt atcaaagtaacGTTTAGCCTTAATTTATATGgattatgtttcacaggcaagctgaaca t" /listShort="S1381, ywtE" /GFF_Attribute="listLong" CDS 3515870..3516730 /gene="ribZB" /locus_tag="BSU_35850" /old_locus_tag="BSU35850" /EC_number="3.1.3.-" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 26316208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase (promiscuous activity)" /protein_id="NP_391466.1" /db_xref="EnsemblGenomes-Gn:BSU35850" /db_xref="EnsemblGenomes-Tr:CAB15602" /db_xref="GOA:P96741" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12536" /db_xref="UniProtKB/Swiss-Prot:P96741" /translation="MKCIAIDLDGTLLNKESVISAENREAIKRAVDAGILVTICTGRA TFDVKALLDDLDIPIIAANGGTIHDTGYRLISRTLMDQEAGKAIADYLLSKNIYFEVY TDDHLLSPFDGEAKLHAELDILKSANPNEQTDDLWQGAMTQFKQFGIKPIPHIESVFD GGENIYKLLCFSFDMDKLKQAKEELKHHKKLAQTSSGKHIIEILPASSGKGRALTKLA DIYGIETQDIYAIGDSPNDLSMFEVAGHRIAMENAIDELKEKSTFVTKSNDENGVAYF IDQLLSGQYA*" gene 3515870..3516730 /gene="ribZB" /locus_tag="BSU_35850" /old_locus_tag="BSU35850" downshifts 3516711 /Source="Nicolas_upshifts" /id="D1854" /incds=0 /nref=163 /ntot=235 /MaxReadThrough="3.35965" /MaxDrop="5.65658" /score="24.125299" /energy="-9.8" /TU="NA" /idTUdmin="U2809" /TUdmin=0 /isTUend="TRUE" CDS complement(3516764..3518005) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" /EC_number="3.4.19.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12073126, 12644511, 16689787, 16952838, 26158264, 28664519" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073126, 12644511, 16689787, 16952838, 26158264, 28664519; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-DD-glutamyl hydrolase (PGA depolymerase)" /protein_id="NP_391467.1" /db_xref="EnsemblGenomes-Gn:BSU35860" /db_xref="EnsemblGenomes-Tr:CAB15603" /db_xref="GOA:P96740" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG12535" /db_xref="UniProtKB/Swiss-Prot:P96740" /translation="MNTLANWKKFLLVAVIICFLVPIMTKAEIAEADTSSELIVSEAK NLLGYQYKYGGETPKEGFDPSGLIQYVFSKADIHLPRSVNDQYKIGTAVKPENLKPGD ILFFKKEGSTGTVPTHDALYIGDGQMVHSTQSKGVIITNYKKSSYWSGTYIGARRIAA DPATADVPVVQEAEKYIGVPYVFGGSTPSEGFDCSGLVQYVFQQALGIYLPRSAEQQW AVGEKVAPQNIKPGDVVYFSNTYKTGISHAGIYAGAGRFIQASRSEKVTISYLSEDYW KSKMTGIRRFDNLTIPKENPIVSEATLYVGEVPYKQGGVTPETGFDTAGFVQYVYQKA AGISLPRYATSQYNAGTKIEKADLKPGDIVFFQSTSLNPSIYIGNGQVVHVTLSNGVT ITNMNTSTYWKDKYAGSIRVQ*" gene complement(3516764..3518005) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" downshifts complement(3516783) /Source="Nicolas_upshifts" /id="D1855" /incds=0 /nref=228 /ntot=317 /MaxReadThrough="2.27329" /MaxDrop="7.15996" /score="10.2499259" /energy="-9.8" /TU="NA" /idTUdmin="U2812" /TUdmin="-18" /isTUend="TRUE" promotor_-10 complement(3518027..3518045) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3518049) /Source="Nicolas_upshifts" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" promotor_-35 complement(3518058..3518065) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3518146..3518313) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16267300, 16689787, 20812257, 21357437, 23583563, 25843804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267300, 16689787, 20812257, 21357437, 23583563, 25843804; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor required extrachromosomal elements maintenance" /protein_id="NP_391468.1" /db_xref="EnsemblGenomes-Gn:BSU35870" /db_xref="EnsemblGenomes-Tr:CAB15604" /db_xref="SubtiList:BG12534" /db_xref="UniProtKB/Swiss-Prot:P96739" /translation="MKFVKAIWPFVAVAIVFMFMSAFKFNDQLTDQEKQKIDMEMNKI QQQEEPVNANK*" gene complement(3518146..3518313) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" downshifts complement(3518173) /Source="Nicolas_upshifts" /id="D1856" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="0.6752" /MaxDrop="2.78178" /score="24.9141523" /energy="-14.7" /TU="NA" /idTUdmin="U2812" /TUdmin="-1408" /isTUend="FALSE" CDS complement(3518328..3519470) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" /EC_number="6.3.2.-" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 12644511, 16689787, 19745567, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 12644511, 16689787, 19745567, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (acid resistance)" /protein_id="NP_391469.1" /db_xref="EnsemblGenomes-Gn:BSU35880" /db_xref="EnsemblGenomes-Tr:CAB15605" /db_xref="InterPro:IPR019079" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12533" /db_xref="UniProtKB/Swiss-Prot:P96738" /translation="MKKELSFHEKLLKLTKQQKKKTNKHVFIAIPIVFVLMFAFMWAG KAETPKVKTYSDDVLSASFVGDIMMGRYVEKVTEQKGADSIFQYVEPIFRASDYVAGN FENPVTYQKNYKQADKEIHLQTNKESVKVLKDMNFTVLNSANNHAMDYGVQGMKDTLG EFAKQNLDIVGAGYSLSDAKKKISYQKVNGVTIATLGFTDVSGKGFAAKKNTPGVLPA DPEIFIPMISEAKKHADIVVVQSHWGQEYDNDPNDRQRQLARAMSDAGADIIVGHHPH VLEPIEVYNGTVIFYSLGNFVFDQGWTRTRDSALVQYHLKKNGTGRFEVTPIDIHEAT PAPVKKDSLKQKTIIRELTKDSNFAWKVEDGKLTFDIDHSDKLKSK*" gene complement(3518328..3519470) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" CDS complement(3519489..3519938) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 15849754, 16689787, 16850406, 19734658" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 15849754, 16689787, 16850406, 19734658; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate amide ligase/translocase subunit" /protein_id="NP_391470.1" /db_xref="EnsemblGenomes-Gn:BSU35890" /db_xref="EnsemblGenomes-Tr:CAB15606" /db_xref="GOA:P96737" /db_xref="InterPro:IPR008338" /db_xref="SubtiList:BG12532" /db_xref="UniProtKB/Swiss-Prot:P96737" /translation="MFGSDLYIALILGVLLSLIFAEKTGIVPAGLVVPGYLGLVFNQP VFILLVLLVSLLTYVIVKYGLSKFMILYGRRKFAAMLITGIVLKIAFDFLYPIVPFEI AEFRGIGIIVPGLIANTIQKQGLTITFGSTLLLSGATFAIMFVYYLI*" gene complement(3519489..3519938) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" promotor_-35 3519632..3519638 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-35" upshifts 3519646 /Source="Nicolas_upshifts" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" promotor_-10 3519652..3519670 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-10" S_feature 3519659..3521868 /Source="Nicolas_S_feature" /locus_tag="new_3699152_3701361" /HighExp="Sw, Salt, dia5, BC, B60, Diami, Lbstat, H2O2, dia15, Gly" /AntisenseName="pgsB" /AntisenseCor="7.6745622610153399E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="0.40410200000000002" /TUshortSig="SigB" /TUshortPSig="0.853" /TUlongSig="NA" /TUlongPSig="NA" /label="S1382" CDS complement(3519953..3521134) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11606194, 11751809, 12644511, 16689787, 19420703, 19734658, 27446033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (ATP-dependentamide ligase)" /protein_id="NP_391471.2" /db_xref="EnsemblGenomes-Gn:BSU35900" /db_xref="EnsemblGenomes-Tr:CAB15607" /db_xref="GOA:P96736" /db_xref="InterPro:IPR008337" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="SubtiList:BG12531" /db_xref="UniProtKB/Swiss-Prot:P96736" /translation="MWLLIIACAVILVIGILEKRRHQKNIDALPVRVNINGIRGKSTV TRLTTGILIEAGYKTVGKTTGTDARMIYWDTPEEKPIKRKPQGPNIGEQKEVMRETVE RGANAIVSECMAVNPDYQIIFQEELLQANIGVIVNVLEDHMDVMGPTLDEIAEAFTAT IPYNGHLVITDSEYTEFFKQKAKERNTKVIIADNSKITDEYLRKFEYMVFPDNASLAL GVAQALGIDEETAFKGMLNAPPDPGAMRILPLISPSEPGHFVNGFAANDASSTLNIWK RVKEIGYPTDDPIIIMNCRADRVDRTQQFANDVLPYIEASELILIGETTEPIVKAYEE GKIPADKLHDLEYKSTDEIMELLKKRMHNRVIYGVGNIHGAAEPLIEKIHEYKVKQLV S*" gene complement(3519953..3521134) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" promotor_-35 3521848..3521855 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3521870 /Source="Nicolas_upshifts" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" promotor_-10 3521871..3521890 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3521891) /Source="Nicolas_upshifts" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3521896..3521910) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3521918..3521922) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3521918..3522898 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11750820, 16519689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11750820, 16519689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="ribose operon repressor (LacI family, D-ribose)" /protein_id="NP_391472.1" /db_xref="EnsemblGenomes-Gn:BSU35910" /db_xref="EnsemblGenomes-Tr:CAB15608" /db_xref="GOA:P36944" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10876" /db_xref="UniProtKB/Swiss-Prot:P36944" /translation="MATIKDVAGAAGVSVATVSRNLNDNGYVHEETRTRVIAAMAKLN YYPNEVARSLYKRESRLIGLLLPDITNPFFPQLARGAEDELNREGYRLIFGNSDEELK KELEYLQTFKQNHVAGIIAATNYPDLEEYSGMNYPVVFLDRTLEGAPSVSSDGYTGVK LAAQAIIHGKSQRITLLRGPAHLPTAQDRFNGALEILKQAEVDFQVIETASFSIKDAQ SMAKELFASYPATDGVIASNDIQAAAVLHEALRRGKNVPEDIQIIGYDDIPQSGLLFP PLSTIKQPAYDMGKEAAKLLLGIIKKQPLAETAIQMPVTYIGRKTTRKED*" gene 3521918..3522898 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" promotor_-35 3522747..3522754 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3522768..3522787 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3522783 /Source="Nicolas_upshifts" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" CDS 3522900..3523781 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" /EC_number="2.7.1.15" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 16978644; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribokinase" /protein_id="NP_391473.1" /db_xref="EnsemblGenomes-Gn:BSU35920" /db_xref="EnsemblGenomes-Tr:CAB15609" /db_xref="GOA:P36945" /db_xref="InterPro:IPR002139" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR011877" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG10877" /db_xref="UniProtKB/Swiss-Prot:P36945" /translation="MRNICVIGSCSMDLVVTSDKRPKAGETVLGTSFQTVPGGKGANQ AVAAARLGAQVFMVGKVGDDHYGTAILNNLKANGVRTDYMEPVTHTESGTAHIVLAEG DNSIVVVKGANDDITPAYALNALEQIEKVDMVLIQQEIPEETVDEVCKYCHSHDIPII LNPAPARPLKQETIDHATYLTPNEHEASILFPELTISEALALYPAKLFITEGKQGVRY SAGSKEVLIPSFPVEPVDTTGAGDTFNAAFAVALAEGKDIEAALRFANRAASLSVCSF GAQGGMPTRNEVEELLS*" gene 3522900..3523781 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" CDS 3523778..3524173 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" /EC_number="5.4.99.62" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 12738765, 21276853; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose pyranase" /protein_id="NP_391474.1" /db_xref="EnsemblGenomes-Gn:BSU35930" /db_xref="EnsemblGenomes-Tr:CAB15610" /db_xref="GOA:P36946" /db_xref="InterPro:IPR007721" /db_xref="InterPro:IPR023064" /db_xref="InterPro:IPR023750" /db_xref="PDB:1OGC" /db_xref="PDB:1OGD" /db_xref="PDB:1OGE" /db_xref="PDB:1OGF" /db_xref="SubtiList:BG10878" /db_xref="UniProtKB/Swiss-Prot:P36946" /translation="MKKHGILNSHLAKILADLGHTDKIVIADAGLPVPDGVLKIDLSL KPGLPAFQDTAAVLAEEMAVEKVIAAAEIKASNQENAKFLENLFSEQEIEYLSHEEFK LLTKDAKAVIRTGEFTPYANCILQAGVLF*" gene 3523778..3524173 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" CDS 3524189..3525670 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ATP-binding protein)" /protein_id="NP_391475.1" /db_xref="EnsemblGenomes-Gn:BSU35940" /db_xref="EnsemblGenomes-Tr:CAB15611" /db_xref="GOA:P36947" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015861" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10879" /db_xref="UniProtKB/Swiss-Prot:P36947" /translation="MQIEMKDIHKTFGKNQVLSGVSFQLMPGEVHALMGENGAGKSTL MNILTGLHKADKGQISINGNETYFSNPKEAEQHGIAFIHQELNIWPEMTVLENLFIGK EISSKLGVLQTRKMKALAKEQFDKLSVSLSLDQEAGECSVGQQQMIEIAKALMTNAEV IIMDEPTAALTEREISKLFEVITALKKNGVSIVYISHRMEEIFAICDRITIMRDGKTV DTTNISETDFDEVVKKMVGRELTERYPKRTPSLGDKVFEVKNASVKGSFEDVSFYVRS GEIVGVSGLMGAGRTEMMRALFGVDRLDTGEIWIAGKKTAIKNPQEAVKKGLGFITEN RKDEGLLLDTSIRENIALPNLSSFSPKGLIDHKREAEFVDLLIKRLTIKTASPETHAR HLSGGNQQKVVIAKWIGIGPKVLILDEPTRGVDVGAKREIYTLMNELTERGVAIIMVS SELPEILGMSDRIIVVHEGRISGEIHAREATQERIMTLATGGR*" gene 3524189..3525670 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" CDS 3525672..3526640 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (permease)" /protein_id="NP_391476.1" /db_xref="EnsemblGenomes-Gn:BSU35950" /db_xref="EnsemblGenomes-Tr:CAB15612" /db_xref="GOA:P36948" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10880" /db_xref="UniProtKB/Swiss-Prot:P36948" /translation="MKTEQLQTEQKRIHFDGVMQKLGPFLGLFILVIIVSILNPSFLE PLNILNLLRQVAINGLIAFGMTFVILTGGIDLSVGAILALSSALVAGMIVSGVDPVLA IILGCIIGAVLGMINGLLITKGKMAPFIATLATMTVFRGLTLVYTDGNPITGLGTNYG FQMFGRGYFLGIPVPAITMVLAFVILWVLLHKTPFGRRTYAIGGNEKAALISGIKVTR VKVMIYSLAGLLSALAGAILTSRLHSAQPTAGESYELDAIAAVVLGGTSLSGGRGRIV GTLIGVLIIGTLNNGLNLLGVSSFYQLVVKGIVILIAVLLDRKKSA*" gene 3525672..3526640 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" CDS 3526652..3527569 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ribose-binding lipoprotein)" /protein_id="NP_391477.1" /db_xref="EnsemblGenomes-Gn:BSU35960" /db_xref="EnsemblGenomes-Tr:CAB15613" /db_xref="GOA:P36949" /db_xref="InterPro:IPR025997" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10881" /db_xref="UniProtKB/Swiss-Prot:P36949" /translation="MKKAVSVILTLSLFLLTACSLEPPQWAKPSNSGNKKEFTIGLSV STLNNPFFVSLKKGIEKEAKKRGMKVIIVDAQNDSSKQTSDVEDLIQQGVDALLINPT DSSAISTAVESANAVGVPVVTIDRSAEQGKVETLVASDNVKGGEMAAAFIADKLGKGA KVAELEGVPGASATRERGSGFHNIADQKLQVVTKQSADFDRTKGLTVMENLLQGHPDI QAVFAHNDEMALGALEAINSSGKDILVIGFDGNKDALASIKDRKLSATVAQQPELIGK LATEAADDILHGKKVQKTISAPLKLETQK*" gene 3526652..3527569 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" promotor_-35 3527578..3527584 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3527599..3527617 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3527601 /Source="Nicolas_upshifts" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" CDS 3527651..3528187 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall binding enzyme" /protein_id="NP_391478.1" /db_xref="EnsemblGenomes-Gn:BSU35970" /db_xref="EnsemblGenomes-Tr:CAB15614" /db_xref="GOA:P96729" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR036028" /db_xref="SubtiList:BG12530" /db_xref="UniProtKB/Swiss-Prot:P96729" /translation="MNKPTKLFSTLALAAGMTAAAAGGAGTIHAQQPETTVSIDDLYS YPIDSYLVSAEALNVRTKPSASSQKADTLHLGDSLKLISFSNADWAKVKYKNGKTGFV STHYIVKAATTVKTKTKTKVYTSADGKSIKTLPADTSVSFLGWSKTNKGGFDFDWVFV DYGGTTGYMKTKDLHMTK*" gene 3527651..3528187 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" downshifts 3528170 /Source="Nicolas_upshifts" /id="D1857" /incds=0 /nref=187 /ntot=255 /MaxReadThrough="5.87246" /MaxDrop="7.38203" /score="26.4284327" /energy="-19" /TU="U2817" /idTUdmin="U2814" /TUdmin="-3" /isTUend="TRUE" S_feature 3528215..3528325 /Source="Nicolas_S_feature" /locus_tag="new_3707708_3707818" /HighExp="Etha, M9-stat, Sw, M40t90, G150, B60, T0.30H, M0t90, T1.30H, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1383" promotor_-35 3528294..3528300 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3528315..3528326 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3528327 /Source="Nicolas_upshifts" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" CDS 3528343..3528639 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11782522" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391479.1" /db_xref="EnsemblGenomes-Gn:BSU35980" /db_xref="EnsemblGenomes-Tr:CAB15615" /db_xref="InterPro:IPR024997" /db_xref="SubtiList:BG12529" /db_xref="UniProtKB/Swiss-Prot:P96728" /translation="MDQFEAAYESYKARQTTADQENVPSGKEEIIAVRRNEEDNIIAV KTNTGRELDYPTALSEAKSGKLAHVDVFHKYGRDILRSEPDGIKENNLSELPDF*" gene 3528343..3528639 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" S_feature 3528640..3529292 /Source="Nicolas_S_feature" /locus_tag="new_3708133_3708785" /HighExp="Etha, M9-stat, S5, S7, S6, Sw, S8, B60, G150, S4" /AntisenseName="ywrO" /AntisenseCor="-0.23279201478213099" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1384" CDS complement(3528679..3529206) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11782522, 14697229, 17768344; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitroreductase (unknown substrate)" /protein_id="NP_391480.1" /db_xref="EnsemblGenomes-Gn:BSU35990" /db_xref="EnsemblGenomes-Tr:CAB15616" /db_xref="GOA:P80871" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12528" /db_xref="UniProtKB/Swiss-Prot:P80871" /translation="MKILVLAVHPHMETSVVNKAWAEELSKHDNITVRDLYKEYPDEA IDVAKEQQLCEEYDRIVFQFPLYWYSSPPLLKKWQDLVLTYGWAFGSEGNALHGKELM LAVSTGSEAEKYQAGGANHYSISELLKPFQATSNLIGMKYLPPYVFYGVNYAAAEDIS HSAKRLAEYIQQPFV*" gene complement(3528679..3529206) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" downshifts complement(3528689) /Source="Nicolas_upshifts" /id="D1858" /incds=0 /nref=48 /ntot=208 /MaxReadThrough="3.48831" /MaxDrop="4.56453" /score="1.41593376" /energy="-17.4" /TU="U2819" /idTUdmin="U2821" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3529226..3529245) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3529239) /Source="Nicolas_upshifts" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" downshifts 3529250 /Source="Nicolas_upshifts" /id="D1859" /incds=0 /nref=26 /ntot=56 /MaxReadThrough="0.805200000000001" /MaxDrop="4.7199" /score="10.409416" /energy="-6.8" /TU="NA" /idTUdmin="U2817" /TUdmin="-1" /isTUend="TRUE" promotor_-35 complement(3529259..3529266) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3529305) /Source="Nicolas_upshifts" /id="D1860" /incds=0 /nref=20 /ntot=149 /MaxReadThrough="4.85403" /MaxDrop="6.46739" /score="-8.02974492" /energy="-5" /TU="U2821" /idTUdmin="U2821" /TUdmin="-616" /isTUend="FALSE" CDS complement(3529306..3530073) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" /EC_number="4.1.1.5" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7685336, 10972805, 12363365, 17183216, 21531833, 26454865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7685336, 10972805, 12363365, 17183216, 21531833, 26454865; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate decarboxylase" /protein_id="NP_391481.1" /db_xref="EnsemblGenomes-Gn:BSU36000" /db_xref="EnsemblGenomes-Tr:CAB15617" /db_xref="GOA:Q04777" /db_xref="InterPro:IPR005128" /db_xref="SubtiList:BG10472" /db_xref="UniProtKB/Swiss-Prot:Q04777" /translation="MKRESNIQVLSRGQKDQPVSQIYQVSTMTSLLDGVYDGDFELSE IPKYGDFGIGTFNKLDGELIGFDGEFYRLRSDGTATPVQNGDRSPFCSFTFFTPDMTH KIDAKMTREDFEKEINSMLPSRNLFYAIRIDGLFKKVQTRTVELQEKPYVPMVEAVKT QPIFNFDNVRGTIVGFLTPAYANGIAVSGYHLHFIDEGRNSGGHVFDYVLEDCTVTIS QKMNMNLRLPNTADFFNANLDNPDFAKDIETTEGSPE*" gene complement(3529306..3530073) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" CDS complement(3530135..3531847) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" /EC_number="2.2.1.6" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972805, 12363365, 17183216, 7685336, 25393087, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972805, 12363365, 17183216, 7685336, 25393087, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate synthase" /protein_id="NP_391482.2" /db_xref="EnsemblGenomes-Gn:BSU36010" /db_xref="EnsemblGenomes-Tr:CAB15618" /db_xref="GOA:Q04789" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012782" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10471" /db_xref="UniProtKB/Swiss-Prot:Q04789" /translation="MTKATKEQKSLVKNRGAELVVDCLVEQGVTHVFGIPGAKIDAVF DALQDKGPEIIVARHEQNAAFMAQAVGRLTGKPGVVLVTSGPGASNLATGLLTANTEG DPVVALAGNVIRADRLKRTHQSLDNAALFQPITKYSVEVQDVKNIPEAVTNAFRIASA GQAGAAFVSFPQDVVNEVTNTKNVRAVAAPKLGPAADDAISAAIAKIQTAKLPVVLVG MKGGRPEAIKAVRKLLKKVQLPFVETYQAAGTLSRDLEDQYFGRIGLFRNQPGDLLLE QADVVLTIGYDPIEYDPKFWNINGDRTIIHLDEIIADIDHAYQPDLELIGDIPSTINH IEHDAVKVEFAEREQKILSDLKQYMHEGEQVPADWKSDRAHPLEIVKELRNAVDDHVT VTCDIGSHAIWMSRYFRSYEPLTLMISNGMQTLGVALPWAIGASLVKPGEKVVSVSGD GGFLFSAMELETAVRLKAPIVHIVWNDSTYDMVAFQQLKKYNRTSAVDFGNIDIVKYA ESFGATGLRVESPDQLADVLRQGMNAEGPVIIDVPVDYSDNINLASDKLPKEFGELMK TKAL*" gene complement(3530135..3531847) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" promotor_-35 3530746..3530755 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3530769..3530788 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3530769 /Source="Nicolas_upshifts" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3531901..3531920) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3531906) /Source="Nicolas_upshifts" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" promotor_-35 3531926..3531933 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3531935..3531939) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3531947..3531966 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3531957 /Source="Nicolas_upshifts" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" CDS 3532005..3532913 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling alsSD, ictEP expression (LysR family)" /protein_id="NP_391483.1" /db_xref="EnsemblGenomes-Gn:BSU36020" /db_xref="EnsemblGenomes-Tr:CAB15619" /db_xref="GOA:Q04778" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10470" /db_xref="UniProtKB/Swiss-Prot:Q04778" /translation="MELRHLQYFIAVAEELHFGKAARRLNMTQPPLSQQIKQLEEEVG VTLLKRTKRFVELTAAGEIFLNHCRMALMQIGQGIELAQRTARGEQGLLVIGFVGSAT YEFLPPIVREYRKKFPSVKIELREISSSRQQEELLKGNIDIGILHPPLQHTALHIETA QSSPCVLALPKQHPLTSKESITIEDLRDEPIITVAKEAWPTLYMDFIQFCEQAGFRPN IVQEATEYQMVIGLVSAGIGMTFVPSSAKKLFNLDVTYRKMDQIQLNAEWVIAYRKDN HNPLIKHFIHISNCQQTRTKESDAGT*" gene 3532005..3532913 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" promotor_-35 3532981..3532989 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3532991..3533123 /Source="Nicolas_S_feature" /locus_tag="new_3712484_3712616" /HighExp="BT, S8, B36, S7, G/S, S6, Pyr, B60, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.14666000000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.896, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1385" upshifts 3532991 /Source="Nicolas_upshifts" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" promotor_-10 3533003..3533022 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3533124..3534452 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/H+ antiporter" /protein_id="NP_391484.1" /db_xref="EnsemblGenomes-Gn:BSU36030" /db_xref="EnsemblGenomes-Tr:CAB15620" /db_xref="GOA:O05224" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12527" /db_xref="UniProtKB/Swiss-Prot:O05224" /translation="MLAFFVTMIFIFWRPKGLNEAIPATFGALMVLLCGSVSLADLGE IGTKVTGASVTILATMIMAIALESFGFFYWVAAKLLQQSKGSGIKLFWLTNLLCFLMT IFLNNDGSILITTPILLLVLKYLGLKKHQKAPYLLSGVLIATASSAPIGVSNIVNLIS LKIIGMDLYLHTAMMFVPSMMGLIFMTCLLFMFFYKRLPKSLPDIPGHFQSLRHRRYH PLHSPSAPLPERNQTKIMLFVLAFVFLVRMSLFAASYTGISVPLVAVIGSFILLSWRW IYFKTSPRDLLYKSPWHIFIFAFTMYVLIYGLHNIGFTELLVSYFEPVVSGSLAHATF ASGISTSVFSNLFNNHPALMISTFTLTEMTLNPSTTKIIYLANIIGSDIGSLLLPMGT LATLIWMHILKQHDESISWGEYIKTTIIIIPLTVLFTLTCLYFWISWLFL*" gene 3533124..3534452 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" downshifts 3534443 /Source="Nicolas_upshifts" /id="D1861" /incds=0 /nref=16 /ntot=32 /MaxReadThrough="1.63489" /MaxDrop="6.12455" /score="-6.14091334" /energy="-11.9" /TU="NA" /idTUdmin="U2823" /TUdmin=0 /isTUend="TRUE" CDS complement(3534509..3535186) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14762006, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391485.1" /db_xref="EnsemblGenomes-Gn:BSU36040" /db_xref="EnsemblGenomes-Tr:CAB15621" /db_xref="InterPro:IPR020139" /db_xref="InterPro:IPR020173" /db_xref="SubtiList:BG12526" /db_xref="UniProtKB/Swiss-Prot:O05223" /translation="MKGLNQFLNTDVEVVISGDTRFVGTLIDIGQDIFVIFDGCNYLY IPLLHLHQINKAKIVTSTEKPFLINPEDPMIEAETQAFSYRNTLNKVKGQFIEVYVTG GRSIHGYVTNVLNDYIVFFSPVFKILFISMHHLKWFTPYSTEQTPYTLDNSQLPVVPS KVPLVRNFEEQIKKNIGELVIFDMGEVPEKVGLLKGVSNNIIELINASGEPVIWKLNH LKTMHLP*" gene complement(3534509..3535186) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" downshifts complement(3534519) /Source="Nicolas_upshifts" /id="D1862" /incds=0 /nref=14 /ntot=28 /MaxReadThrough="1.74629" /MaxDrop="5.1172" /score="-4.02447737" /energy="-9.5" /TU="NA" /idTUdmin="U2824" /TUdmin=0 /isTUend="TRUE" CDS complement(3535246..3536388) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8755863, 10559171, 11737650, 14762006, 19933362, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755863, 10559171, 11737650, 14762006, 19933362, 27185916; Product type s : structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_391486.1" /db_xref="EnsemblGenomes-Gn:BSU36050" /db_xref="EnsemblGenomes-Tr:CAB15622" /db_xref="GOA:P07789" /db_xref="SubtiList:BG10491" /db_xref="UniProtKB/Swiss-Prot:P07789" /translation="MSKRRMKYHSNNEISYYNFLHSMKDKIVTVYRGGPESKKGKLTA VKSDYIALQAEKKIIYYQLEHVKSITEDTNNSTTTIETEEMLDADDFHSLIGHLINQS VQFNQGGPESKKGRLVWLGDDYAALNTNEDGVVYFNIHHIKSISKHEPDLKIEEQTPV GVLEADDLSEVFKSLTHKWVSINRGGPEAIEGILVDNADGHYTIVKNQEVLRIYPFHI KSISLGPKGSYKKEDQKNEQNQEDNNDKDSNSFISSKSYSSSKSSKRSLKSSDDQSSK SGRSSRSKSSSKSSKRSLKSSDYQSSKSGRSSRSKSSSKSSKRSLKSSDYQSSKSSKR SPRSSDYQSSRSPGYSSSIKSSGKQKEDYSYETIVRTIDYHWKRKF*" gene complement(3535246..3536388) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" promotor_-10 complement(3536425..3536444) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3536433) /Source="Nicolas_upshifts" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" S_feature complement(3536435..3536515) /Source="Nicolas_S_feature" /locus_tag="new_3715928_3716008_c" /HighExp="S6, S7, S8, S5, BT, B36, S4, G/S, Pyr, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1386" promotor_-35 complement(3536458..3536466) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3536516..3537604) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762006, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762006, 25115591, 27185916; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein kinase" /protein_id="NP_391487.1" /db_xref="EnsemblGenomes-Gn:BSU36060" /db_xref="EnsemblGenomes-Tr:CAB15623" /db_xref="GOA:Q45535" /db_xref="InterPro:IPR014867" /db_xref="SubtiList:BG11791" /db_xref="UniProtKB/Swiss-Prot:Q45535" /translation="MKNQSNLPLYQLFVHPKDLRELKKDIWDDDPVPAVMKVNQKRLD IDIAYRGSHIRDFKKKSYHISFYQPKTFRGAREIHLNAEYKDPSLMRNKLSLDFFSEL GTLSPKAEFAFVKMNGKNEGVYLELESVDEYYLAKRKLADGAIFYAVDDDANFSLMSD LERETKTSLELGYEKKTGTEEDDFYLQDMIFKINTVPKAQFKSEVTKHVDVDKYLRWL AGIVFTSNYDGFVHNYALYRSGETGLFEVIPWDYDATWGRDIHGERMAADYVRIQGFN TLTARILDESEFRKSYKRLLEKTLQSLFTIEYMEPKIMAMYERIRPFVLMDPYKKNDI ERFDREPDVICEYIKNRSQYLKDHLSIL*" gene complement(3536516..3537604) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" S_feature complement(3537605..3537718) /Source="Nicolas_S_feature" /locus_tag="new_3717098_3717211_c" /HighExp="S6, S8, S7, S5, BT, B36, Pyr, G/S, S4, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1387" promotor_-35 3537660..3537669 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3537682..3537701 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3537695 /Source="Nicolas_upshifts" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" upshifts complement(3537718) /Source="Nicolas_upshifts" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" promotor_-10 complement(3537722..3537736) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3537745..3537749) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3537745..3538332 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14762006, 15621419, 22720735, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14762006, 15621419, 22720735, 25115591, 27185916; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore morphogenetic protein" /protein_id="NP_391488.1" /db_xref="EnsemblGenomes-Gn:BSU36070" /db_xref="EnsemblGenomes-Tr:CAB15624" /db_xref="GOA:P39801" /db_xref="SubtiList:BG11017" /db_xref="UniProtKB/Swiss-Prot:P39801" /translation="MGHYSHSDIEEAVKSAKKEGLKDYLYQEPHGKKRSHKKSHRTHK KSRSHKKSYCSHKKSRSHKKSFCSHKKSRSHKKSYCSHKKSRSHKKSYRSHKKSRSYK KSYRSYKKSRSYKKSCRSYKKSRSYKKSYCSHKKKSRSYKKSCRTHKKSYRSHKKYYK KPHHHCDDYKRHDDYDSKKEYWKDGNCWVVKKKYK*" gene 3537745..3538332 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" CDS 3537833..3538312 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" /function="14.1: Surface structures" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="doubtful CDS (putative in frame frameshift)" /protein_id="YP_009514005.1" /translation="MEKNAVIKSRTALTKNLAAIKNHTALTKNLAVTKNHSVLTKNLA ATKNHTALTRNLAATKNRTVLTKNLAAIKNLTVLTKNLVAIKNLAVLTKNLAATKSLT VLTRKNLAAIRSHAAHTKNLIVPIRNTTKNRTTTATTTKDTMIMTAKKNTGKTAIAG* " gene 3537833..3538312 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" S_feature complement(3538216..3538413) /Source="Nicolas_S_feature" /locus_tag="new_3717709_3717906_c" /HighExp="S5, S6, S4, B60, S3, nit, G/S, SMMPr, S8, ferm" /AntisenseName="cotG" /AntisenseCor="0.60092819988141299" /AntisenseRegPval="-27.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1388" downshifts 3538249 /Source="Nicolas_upshifts" /id="D1863" /incds=1 /nref=1 /ntot=54 /MaxReadThrough="7.80801" /MaxDrop="2.7794" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-154" /isTUend="FALSE" downshifts complement(3538259) /Source="Nicolas_upshifts" /id="D1864" /incds=1 /nref=3 /ntot=23 /MaxReadThrough="4.99409" /MaxDrop="6.67733" /score="-1.37249416" /energy="-5.2" /TU="U2827" /idTUdmin="U2824" /TUdmin="-3740" /isTUend="FALSE" downshifts 3538318 /Source="Nicolas_upshifts" /id="D1865" /incds=0 /nref=41 /ntot=80 /MaxReadThrough="4.68169" /MaxDrop="5.35584" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-85" /isTUend="FALSE" downshifts 3538397 /Source="Nicolas_upshifts" /id="D1866" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="2.30708" /MaxDrop="3.92552" /score="17.1895651" /energy="-10.7" /TU="NA" /idTUdmin="U2825" /TUdmin="-6" /isTUend="TRUE" promotor_-10 complement(3538412..3538431) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3538418) /Source="Nicolas_upshifts" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" promotor_-35 3538440..3538447 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3538444..3538453) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3538462..3538481 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3538468 /Source="Nicolas_upshifts" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" CDS 3538506..3539123 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" /EC_number="1.14.13.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavin-binding monooxygenase" /protein_id="NP_391489.1" /db_xref="EnsemblGenomes-Gn:BSU36080" /db_xref="EnsemblGenomes-Tr:CAB15625" /db_xref="GOA:O05220" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12525" /db_xref="UniProtKB/Swiss-Prot:O05220" /translation="MYIFQADQLSAKDTYKLLSGTVIPRPIAFVTTLSSGGAVNAAPF SFYNVVSSDPPLLSISVNRTEGRQKDTARNAVENGEFVVHVSDEAIIEDINETAASLR PDESELTRTSLHPVESKAVSVPGIKEARVRFECKLERHITFDNDQGITTADLLIGRVV CFHLDEKVYDAEKGYILTDELKPASRLAGNHYAKLGEEFTLIRPS*" gene 3538506..3539123 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" S_feature 3539124..3539224 /Source="Nicolas_S_feature" /locus_tag="new_3718617_3718717" /HighExp="Etha, dia5, Diami, dia15, Lbtran, LBGtran, LPhT, M40t45, M40t90, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1389" downshifts 3539181 /Source="Nicolas_upshifts" /id="D1867" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="4.52989" /MaxDrop="4.48979" /score="-1.9002322" /energy="-14.9" /TU="U2828" /idTUdmin="U2828" /TUdmin="-454" /isTUend="FALSE" promotor_-35 3539250..3539259 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3539271..3539286 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3539272 /Source="Nicolas_upshifts" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" CDS 3539301..3539636 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391490.1" /db_xref="EnsemblGenomes-Gn:BSU36090" /db_xref="EnsemblGenomes-Tr:CAB15626" /db_xref="GOA:O05219" /db_xref="InterPro:IPR025441" /db_xref="SubtiList:BG12524" /db_xref="UniProtKB/Swiss-Prot:O05219" /translation="MTNFWILMLIAITISLASQFFIKKKYGIDKSGWRYKHVSNTHKW IEITLLILFVFSLSFFPVEYLLLLFFIVIDSIRIFMEWHYRPEDKQYMYHIVEVSLMF MLLIYVCTL*" gene 3539301..3539636 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" promotor_-10 complement(3539592..3539610) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3539601) /Source="Nicolas_upshifts" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3539625..3539630) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3539635 /Source="Nicolas_upshifts" /id="D1868" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="5.64855" /MaxDrop="3.64569" /score="-1.9002322" /energy="-14.9" /TU="U2829" /idTUdmin="U2828" /TUdmin=0 /isTUend="TRUE" CDS complement(3539641..3541218) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" /EC_number="3.5.1.126" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12823818, 14762019, 19935659, 27303801, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxamate amidohydrolase" /protein_id="NP_391491.1" /db_xref="EnsemblGenomes-Gn:BSU36100" /db_xref="EnsemblGenomes-Tr:CAB15627" /db_xref="GOA:O05218" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="SubtiList:BG12523" /db_xref="UniProtKB/Swiss-Prot:O05218" /translation="MNKSVIGTKQMVVSPHYLASQAGNRILDKGGNAFDAAVAVSACL AVVYPHMTGLGGDSFWLTFHQETKAVKVYNGSGRSGKNVTRDVYKGKSAIPLRGIDSA ITVPGMVDSWDAVLKEYGRLSLADVLEPARDYAQNGFPVSADQCRHTEKNIELLASTP YTADIFTRRGKAPVPGERFVQKELADSLNLIAEKGRSAFYEGDLAQRIVSHLQNNGSY MTIDDFKAHRGEWAAPVSSDYRGYSVYQAPPNSQGFTGLLTLNILENYDFTQIEHGSF EYYHVLVEALKKSFLDRDAVLTDPAFADIPLERLLDKRYAKQLAEEIGYLAIPAESRP VGSDTAYAAVIDADGNAVSFIQSLYFEFGSAVTAGDTGILLQNRGSFFSLDENHVNTL EPRKRTFHTLMPAMVCKGGKPKILYGTQGGEGQPQTQTAIITRMLDYGMHPQQAISEP RWVWGRTWGEEYEGLRVEGRFTDKTIQKLKDSGHLVEVVGDYDPLMGQAAAIKVDEEG FLQGGADPRGDGAAVGI*" gene complement(3539641..3541218) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" S_feature 3539680..3541391 /Source="Nicolas_S_feature" /locus_tag="new_3719173_3720884" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T-0.40H, T0.0H, Salt" /AntisenseName="ywrD" /AntisenseCor="0.153519829066777" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1390" promotor_-35 3541369..3541376 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3541387..3541406 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3541393 /Source="Nicolas_upshifts" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" CDS 3541432..3541908 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23989926; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional negative regulator of chromate transport (Lrp/AsnC family)" /protein_id="NP_391492.1" /db_xref="EnsemblGenomes-Gn:BSU36110" /db_xref="EnsemblGenomes-Tr:CAB15628" /db_xref="GOA:O05217" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12522" /db_xref="UniProtKB/Swiss-Prot:O05217" /translation="MSHEYQIPNLVLDETDKQILTILHEEGRISYTDLGKRVDLSRVA VQARINQLIEAGVIEKFTAVINPAKIGIHVSVFFNVEVEPQFLEEVALKLEEEPAVTS LYHMTGPSKLHMHGIFTNDQEMEEFLTKRLYPLRGVVSVDCQMLIKRYKSRMGMKL*" gene 3541432..3541908 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" CDS 3541922..3542515 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit N" /protein_id="NP_391493.1" /db_xref="EnsemblGenomes-Gn:BSU36120" /db_xref="EnsemblGenomes-Tr:CAB15629" /db_xref="GOA:O05216" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12521" /db_xref="UniProtKB/Swiss-Prot:O05216" /translation="MKNHPYRDMTAAMVRTGILGFGGGPSVIPLIRHEAVNKYKWIDD DEFGEILAIANALPGPIATKMAAYLGFKLKGTLGAIVAILAHILPTCLAMVGLFAAVN VLSHSAIVAGMIGAVTPVIAVMLGIMAYEFGQKALKGFGWVTGILFFIIAFIGLQTLQ INPGLVIIIFLAYGAFHFKLKDKITNKHSKDKGMSAS*" gene 3541922..3542515 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" CDS 3542512..3543048 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit C" /protein_id="NP_391494.1" /db_xref="EnsemblGenomes-Gn:BSU36130" /db_xref="EnsemblGenomes-Tr:CAB15630" /db_xref="GOA:O05215" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12520" /db_xref="UniProtKB/Swiss-Prot:O05215" /translation="MISIYLFMAFFIANLLGYGGGPASIPLMFEEVVNRYSWLSNDQF SNMLALANALPGPIATKIAAYVGYSAGGWPGFLIALIATVVPSALALIVLLRIIQRFR QSPVIKGMTLSVQPVIAVMMLILTWQIGADGIKAIGWVQSIVITGISLLAMTKFKMHP AFLIIAAFLYGGLVIPYL*" gene 3542512..3543048 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" downshifts 3543029 /Source="Nicolas_upshifts" /id="D1869" /incds=0 /nref=4 /ntot=90 /MaxReadThrough="0.0513700000000004" /MaxDrop="3.46649" /score="29.5508265" /energy="-8.6" /TU="NA" /idTUdmin="U2829" /TUdmin=28 /isTUend="FALSE" CDS complement(3543075..3543296) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391495.1" /db_xref="EnsemblGenomes-Gn:BSU36140" /db_xref="EnsemblGenomes-Tr:CAB15631" /db_xref="SubtiList:BG12519" /db_xref="UniProtKB/Swiss-Prot:P96727" /translation="MKFLLSVIAGLLILALYLFWKVQPPVWIQVETNSSQLKQSVRMA GTTLQVKHMIKSDAGEETAVISNGISGLK*" gene complement(3543075..3543296) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" upshifts 3543243 /Source="Nicolas_upshifts" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 3543250..3543251 /Source="Nicolas_upshift_promotors" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3543293..3543838) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391496.1" /db_xref="EnsemblGenomes-Gn:BSU36150" /db_xref="EnsemblGenomes-Tr:CAB15632" /db_xref="GOA:P96726" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLI" /db_xref="SubtiList:BG12518" /db_xref="UniProtKB/Swiss-Prot:P96726" /translation="MKIAVINGGTRSGGNTDVLAEKAVQGFDAEHIYLQKYPIQPIED LRHAQGGFRPVQDDYDSIIERILQCHILIFATPIYWFGMSGTLKLFIDRWSQTLRDPR FPDFKQQMSVKQAYVIAVGGDNPKIKGLPLIQQFEHIFHFMGMSFKGYVLGEGNRPGD ILRDHQALSAASRLLKRSDAI*" gene complement(3543293..3543838) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" promotor_-35 3543855..3543862 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3543877..3543896 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3543881 /Source="Nicolas_upshifts" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" CDS 3543961..3544842 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391497.1" /db_xref="EnsemblGenomes-Gn:BSU36160" /db_xref="EnsemblGenomes-Tr:CAB15633" /db_xref="GOA:P96725" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12517" /db_xref="UniProtKB/Swiss-Prot:P96725" /translation="MELKQLITFITAAEHVNFTLTAKMLNYAQSSVTSQIKSLEEEIG TPLFERLGKRLILTEAGKTFKSYAQKIIALTEEAKMATNQVRETTGTLKIGATESQCT YRLPPIIKEFKQAFPQVKLIFKPYISNEQAKEQLLQGQLDITFILDVNRMEDALHVES LIQDEIKMVAANDHPFPADLPVTLKDLQNETLLLTEDGCSYRTLFENNLHDSGIYPNK LEFVSIEAIKQCVMAGLGIGILPEMTVKDDIAAGRMKELNWQSDCPVFTQLAWHKDKW MSAPLKAFIDLTRKTFK*" gene 3543961..3544842 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" CDS complement(3544927..3545643) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" /EC_number="3.1.21.7" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1692969, 22056936, 27530626" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1692969, 22056936, 27530626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease V" /protein_id="NP_391498.2" /db_xref="EnsemblGenomes-Gn:BSU36170" /db_xref="EnsemblGenomes-Tr:CAB15634" /db_xref="GOA:P96724" /db_xref="InterPro:IPR007581" /db_xref="PDB:3GA2" /db_xref="SubtiList:BG12516" /db_xref="UniProtKB/Swiss-Prot:P96724" /translation="MKVFDVHKFDMKKEQDFLQVQFNLKNRINLSPTIHPDSINTCAG VDLAYWEQDGEPYGVCCIIVIDADTKEVIEKVHSMGRISVPYVSGFLAFRELPLIIEA AKKLETEPDVFLFDGNGYLHYNHMGVATHAAFFLGKPTIGIAKTYLKIKGCDFVTPEI EVGAYTDIIIDGEVYGRALRTRRDVKPIFLSCGNYIDLDSSYQITMSLINQESRLPIP VRLADLETHVLRTFYQKNHV*" gene complement(3544927..3545643) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" downshifts complement(3544947) /Source="Nicolas_upshifts" /id="D1870" /incds=0 /nref=44 /ntot=216 /MaxReadThrough="1.91774" /MaxDrop="3.62442" /score="12.1019223" /energy="-7.4" /TU="NA" /idTUdmin="U2834" /TUdmin=0 /isTUend="TRUE" CDS complement(3545653..3546117) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease antitoxin" /protein_id="NP_391499.1" /db_xref="EnsemblGenomes-Gn:BSU36180" /db_xref="EnsemblGenomes-Tr:CAB15635" /db_xref="InterPro:IPR011652" /db_xref="SubtiList:BG12515" /db_xref="UniProtKB/Swiss-Prot:P96723" /translation="MENEYDMKSIKEKGVDFEDLWFSSVSDEILDNPEDENGQPFTGL AYELYPNGQIIYFTKYKNGLAHGLTCEFYENGNKKSEKEYRYGQLHGISIIWFENGRK KSEQQYEHSILISEKNWDEEGNLLNKYEIDTDSPHFEILESRRETHINLGRE*" gene complement(3545653..3546117) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" CDS complement(3546107..3547915) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" /EC_number="3.1.-.-" /function="15.8: Toxin production and resistance" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease toxin" /protein_id="NP_391500.1" /db_xref="EnsemblGenomes-Gn:BSU36190" /db_xref="EnsemblGenomes-Tr:CAB15636" /db_xref="GOA:P96722" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR025968" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG12514" /db_xref="UniProtKB/Swiss-Prot:P96722" /translation="MSKVFESKSLIEEAKSRKKQYETLEEQLNTLKKAFQGVADLGDN FKGNGADNIKDFFQGQAEIVDSWLTLVSAQIAFLNGISGDIKDQELNDSYVETSFLDH ELPNGDLKASEIVSAHKEEIDSILSGISDIIDLDMYTLDDYADKMGDAQKIRRDTITA VDKLDESLTTEYQNLESLDNAVLTKYSVLMQATSNGKSASPMYYDKKAFHSNEVYKSV IEVENQGTTYIDAKTQQAEARRLQEKAEEEANKPWYEKTWDGVCNFTGEVTGYYDYKR ATEGVDPVTGEKLSTAERVTAGAMAAAGFIPVVGWAGRAFKGGKAIYKTGKAAIAAEH ALDAYKTGKSLDILKMTEMGAYGLVASNGFSEAVTGRDMFGNKVSEEKRKQGALEAIT IIGGAGLAHYFDRLYQKNAPYVNKVSNESLISNIAKTTEEKQTRLQYLRNKHGVLSKE DLHHRINLRAEVLNELSRIKSSGLTKKQRGPAVAGVLDKKTGNYYFGINNIDGKPPKV LHPLIHDRIVNMPTELKEGYIKTSGAGSHAEVNALNEALLQRPDADLKDLMVYVVSAR KINKKMPEGVPMPRCPHCEYITQNTNYIPEALKYGK*" gene complement(3546107..3547915) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" CDS complement(3547934..3548194) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391501.1" /db_xref="EnsemblGenomes-Gn:BSU36200" /db_xref="EnsemblGenomes-Tr:CAB15637" /db_xref="InterPro:IPR020299" /db_xref="SubtiList:BG12513" /db_xref="UniProtKB/Swiss-Prot:P96721" /translation="MSEIKLKYDTVIKTLDSVKDALADVSIGAAGSNGKNSLDYTKKY HEREENIKTMLGDYKKAVQKNIEDTKDNVDSLKEQDEAIAVK*" gene complement(3547934..3548194) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" CDS complement(3548204..3548626) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15101989" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391502.1" /db_xref="EnsemblGenomes-Gn:BSU36210" /db_xref="EnsemblGenomes-Tr:CAB15638" /db_xref="InterPro:IPR020326" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG12512" /db_xref="UniProtKB/Swiss-Prot:P96720" /translation="MGYESMLADIKSSLNGKISDVEDKIEKLKKAKKDIDTLQEEAIT EIKEIVKPELGKHWTGTKADDFDKGREEAKSEASKIVNDKYNEYMASINGKIFDLEWD KAKYASELFIANGAADLLKKGEEFAEEVGNTISKLKWW*" gene complement(3548204..3548626) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" S_feature complement(3548627..3548709) /Source="Nicolas_S_feature" /locus_tag="new_3728120_3728202_c" /HighExp="T2.30H, T4.0H, T5.0H, T3.0H, T3.30H, T1.30H, T2.0H, S4, T-0.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1391" promotor_-10 complement(3548701..3548720) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3548709) /Source="Nicolas_upshifts" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" promotor_-35 complement(3548733..3548740) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3548843..3548968) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514006.1" /translation="MTKSDMADQMKNINMNNKLSAERGRSTTSASFKCLYNYDIR*" gene complement(3548843..3548968) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" S_feature complement(3548886..3549017) /Source="Nicolas_S_feature" /locus_tag="new_3728379_3728510_c" /HighExp="HiOs, BI, M9-tran, T-2.40H, MG 150, Sw, M9-exp, S1, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19133600000000001" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1392" downshifts complement(3548929) /Source="Nicolas_upshifts" /id="D1871" /incds=0 /nref=29 /ntot=208 /MaxReadThrough="3.03928" /MaxDrop="3.47153" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2835" /TUdmin=0 /isTUend="TRUE" CDS complement(3549018..3549803) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391503.1" /db_xref="EnsemblGenomes-Gn:BSU36220" /db_xref="EnsemblGenomes-Tr:CAB15639" /db_xref="InterPro:IPR015315" /db_xref="InterPro:IPR035948" /db_xref="PDB:1PV5" /db_xref="SubtiList:BG12511" /db_xref="UniProtKB/Swiss-Prot:P96719" /translation="MNHLPEKMRPYRDLLEKSAKEYVKLNVRKGKTGRYDSKIAGDPY FPKHETYPTDENGQPMKLLAQINFSHIPQLDGYPSSGILQFYISVHDDVYGLNFDDRC EQKNFRVIYFENIVENDDELVSDFSFIGTGECDFPILSEAAVEPVKSSEWVLPTDFQF EQYTGMETMEFFGQFGEDEEDIYNELAENGFGHKIGGYASFTQHDPREYAYKEHTIML LQIDSDDDIDSMWGDVGIANFFITPEDLRKKDFSNVLYNWDCS*" gene complement(3549018..3549803) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" S_feature complement(3549804..3549919) /Source="Nicolas_S_feature" /locus_tag="new_3729297_3729412_c" /HighExp="HiOs, T-1.40H, T-2.40H, T-3.40H, M9-tran, MG 150, SMM, GM 150, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1393" promotor_-10 complement(3549912..3549931) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3549919) /Source="Nicolas_upshifts" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" promotor_-35 complement(3549945..3549952) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3549995..3551317) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 15866923, 16415592" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 15866923, 16415592; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose dehydrogenase" /protein_id="NP_391504.1" /db_xref="EnsemblGenomes-Gn:BSU36230" /db_xref="EnsemblGenomes-Tr:CAB15640" /db_xref="GOA:P96718" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12510" /db_xref="UniProtKB/Swiss-Prot:P96718" /translation="MNITVIGTGYVGLVTGVSLSEIGHHVTCIDIDAHKIDEMRKGIS PIFEPGLEELMRKNTADGRLNFETSYEKGLAQADIIFIAVGTPQKSDGHANLEQITDA AKRIAKHVKRDTVVVTKSTVPVGTNDLINGLITEHLAEPVSISVASNPEFLREGSAIY DTFHGDRIVIGTADEKTANTLEELFRPFQIPIYQTDIRSAEMIKYASNAFLATKISFI NEISNICEKVGADIEAVAYGMGQDKRIGSQFLKAGIGYGGSCFPKDTNALVQIAGNVE HDFELLKSVIKVNNNQQAMLVDKALNRLGGVTGKTIALLGLSFKPNTDDMREAPSIVI ADRLAALDARIRAYDPIAVSHAKHVLPQAVEYKETIEEAVKGSDAVMILTDWADIKQF PLAAYQDLMETPLIFDGRNCYTLDEALAAGVEYYSVGRKAVVPSGAIQ*" gene complement(3549995..3551317) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" downshifts complement(3550007) /Source="Nicolas_upshifts" /id="D1872" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.29767" /MaxDrop="6.20721" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2836" /TUdmin=0 /isTUend="TRUE" upshifts complement(3551351) /Source="Nicolas_upshifts" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" S_feature complement(3551353..3551478) /Source="Nicolas_S_feature" /locus_tag="new_3730846_3730971_c" /HighExp="dia15, H2O2, Diami, dia5, LBGstat, Paraq, LBGexp, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.13453899999999999" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1394" promotor_-10 complement(3551353..3551371) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3551387..3551392) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3551458..3551477) /Source="Nicolas_upshift_promotors" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3551478) /Source="Nicolas_upshifts" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" CDS complement(3551512..3552276) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15866923, 16415592, 16549871, 21605684, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15866923, 16415592, 16549871, 21605684, 27148221; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein tyrosine-phosphatase" /protein_id="NP_391505.1" /db_xref="EnsemblGenomes-Gn:BSU36240" /db_xref="EnsemblGenomes-Tr:CAB15641" /db_xref="GOA:P96717" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR016667" /db_xref="PDB:3QY6" /db_xref="PDB:3QY7" /db_xref="SubtiList:BG12509" /db_xref="UniProtKB/Swiss-Prot:P96717" /translation="MIDIHCHILPAMDDGAGDSADSIEMARAAVRQGIRTIIATPHHN NGVYKNEPAAVREAADQLNKRLIKEDIPLHVLPGQEIRIYGEVEQDLAKRQLLSLNDT KYILIEFPFDHVPRYAEQLFYDLQLKGYIPVIAHPERNREIRENPSLLYHLVEKGAAS QITSGSLAGIFGKQLKAFSLRLVEANLIHFVASDAHNVKTRNFHTQEALYVLEKEFGS ELPYMLTENAELLLRNQTIFRQPPQPVKRRKLFGFF*" gene complement(3551512..3552276) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" downshifts complement(3552295) /Source="Nicolas_upshifts" /id="D1873" /incds=0 /nref=4 /ntot=152 /MaxReadThrough="3.17433" /MaxDrop="3.31415" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-330" /isTUend="FALSE" CDS complement(3552329..3553042) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" /EC_number="2.7.10.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maintenance protein tyrosine kinase involved in biofilm formation" /protein_id="NP_391506.1" /db_xref="EnsemblGenomes-Gn:BSU36250" /db_xref="EnsemblGenomes-Tr:CAB15642" /db_xref="GOA:P96716" /db_xref="InterPro:IPR005702" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12508" /db_xref="UniProtKB/Swiss-Prot:P96716" /translation="MALRKNRGSRMQRNVIAMTEPKSLNSEQYRTIRTNIEFASVDRQ MKSVMITSACPGEGKSTTAANLAVVFAQQGKKVLLIDADLRKPTVHTAFFLENTVGLT SVLLKKSSMEQAVQASNEKHLDVLTSGPIPPNPAELLSSKWMKELAYEACAAYDMVIF DTPPILAVADAQILGNVADGSVLVISSGKTEKEQAAKAKEALATCKSKLLGAIMNGKK LSKHSEYGYYGTKDNFMQK*" gene complement(3552329..3553042) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" downshifts complement(3552346) /Source="Nicolas_upshifts" /id="D1874" /incds=0 /nref=10 /ntot=157 /MaxReadThrough="4.4352" /MaxDrop="4.08842" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-381" /isTUend="FALSE" CDS complement(3553032..3553778) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 23939619, 24493247, 26283769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 23939619, 24493247, 26283769; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of PtkA protein tyrosine kinase activity; modulation of biofilm formation" /protein_id="NP_391507.1" /db_xref="EnsemblGenomes-Gn:BSU36260" /db_xref="EnsemblGenomes-Tr:CAB15643" /db_xref="GOA:P96715" /db_xref="InterPro:IPR003856" /db_xref="InterPro:IPR032807" /db_xref="SubtiList:BG12507" /db_xref="UniProtKB/Swiss-Prot:P96715" /translation="MGESTSLKEILSTLTKRILLIMIVTAAATAAGGLISFFALTPIY ENSTQILVNQSKNERKEVQFNDVQTNLQLINTYNVIIKSPAILDEVIKEMGLSMTSQE LNDKITVSSEQDSQVVNISVRDENAETAAHIANTIASVFQDKITSIMNVDNVSILSKA EVSEHPSPVSPKPLLNIAIAFAAGLAGSIGLAFLLEHLDNTIKSEEQLESLLDIPVLG TVSTIANEQKTAKTLQGFQSEKTGSGHFGA*" gene complement(3553032..3553778) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" promotor_-10 complement(3553810..3553829) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3553822) /Source="Nicolas_upshifts" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" promotor_-35 complement(3553846..3553849) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3554012..3554155) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097792.1" /db_xref="EnsemblGenomes-Gn:BSU36269" /db_xref="EnsemblGenomes-Tr:CAX52703" /db_xref="UniProtKB/Swiss-Prot:C0H3S3" /translation="MSEKKLNQEEFLKILMHAHEIGEQSSEMTTKEMLENLISHIKNG YAT*" gene complement(3554012..3554155) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" downshifts complement(3554033) /Source="Nicolas_upshifts" /id="D1875" /incds=0 /nref=221 /ntot=264 /MaxReadThrough="2.76798" /MaxDrop="8.13076" /score="15.8630799" /energy="-9.3" /TU="U2839" /idTUdmin="U2841" /TUdmin=0 /isTUend="TRUE" S_feature complement(3554156..3554241) /Source="Nicolas_S_feature" /locus_tag="new_3733649_3733734_c" /HighExp="S6, S8, S7, MG-0.2, S5, M9-stat, MG-0.1, MG 25, T0.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD, SigK" /TUshortPSig="0.275, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1395" misc_feature complement(3554231..3554242) /Source="Nicolas_upshift_promotors" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3554241) /Source="Nicolas_upshifts" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" S_feature complement(3554243..3554473) /Source="Nicolas_S_feature" /locus_tag="new_3733736_3733966_c" /HighExp="S6, S8, S7, S5, BT, Cold, LBGstat, LPhT, Pyr, C30" /AntisenseName="ywqB" /AntisenseCor="3.4267833233812203E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1396" promotor_-35 3554280..3554284 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3554300..3554319 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3554309 /Source="Nicolas_upshifts" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" CDS 3554359..3555969 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative replication initiation protein" /protein_id="NP_391508.2" /db_xref="EnsemblGenomes-Gn:BSU36270" /db_xref="EnsemblGenomes-Tr:CAB15644" /db_xref="GOA:P96714" /db_xref="InterPro:IPR007527" /db_xref="SubtiList:BG12506" /db_xref="UniProtKB/Swiss-Prot:P96714" /translation="MLQNMISKDDVLASAEQLKELLPYNEENVQLIKKALILYRQDSV YRLQAVSPTEVTAYVQDVVPVRVTLNLFVIVKSGCSCPSGRICRHMLAVFLYVYAMFE RVGTFTEYWLEREKLEESKELVRRQFQEKVLPNEESLSSWLAFFDSEFSLWQARTPEG SQNMQGLYYGYLSALKKHAPNKPELKSLYQIHSAIAVWLRMFTLIEAGKLNPEQDFYS LNPYVEQLMDTIYSSIDKLKTYALSFALDPFLDKTPDVIRHLLLKEEIFQYERIRVFG EIWSALLSRPKWVAREQEILKKEAGRRFSPELQFGRLHLEFLQKNDDVIFEEADQFPP EALPYTFQWLSEMTAKKDWKRLKTWYQQIEPIAMGYTKLDKPFKEIRDVIGELFLLLN AYVQQTNDQALFERFAAGCLPYTFTEYSHHLYEKKRYAEWIEIHSLVGFSINEMDKMM LKEIAASDPEALIPAYHREVAFFIDQKNRSSYKEAARYLKKLRTLYKKAKKQKVWERY IQLLSSHYKRLRALQEELQKGKLIDGES*" gene 3554359..3555969 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" promotor_-10 complement(3554461..3554479) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3554473) /Source="Nicolas_upshifts" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" S_feature complement(3554475..3554649) /Source="Nicolas_S_feature" /locus_tag="new_3733968_3734142_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, B60, C30" /AntisenseName="ywqB" /AntisenseCor="-0.10880748846525" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1397" promotor_-35 complement(3554493..3554500) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3554636..3554655) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3554649) /Source="Nicolas_upshifts" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" promotor_-35 complement(3554669..3554677) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3555956..3558724 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9507009, 9614128, 11751638, 17913745, 19282450; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATPase involved in RNA remodelling DNA recombination and repair" /protein_id="NP_391509.1" /db_xref="EnsemblGenomes-Gn:BSU36280" /db_xref="EnsemblGenomes-Tr:CAB15645" /db_xref="GOA:P94593" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR022138" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12505" /db_xref="UniProtKB/Swiss-Prot:P94593" /translation="MASLKEILIHVEQMEDGSFTLSAFDENEQPLPYSHMKKHLFQWH ESSFYGTFLEDVSFIGTTAVLLSPWMTVELLGKNSFNSFSSVQLTEETEPLIEAASTI YEFIADGDFMPDYDAWTNGVFRWKDRDNILEGFTAEWFSAAVQDYIQYDDDLREKWEH IKEKSPAVTTFRGHFLDEEDFLEGIGWIDDQSPFTVGLRLNEPDFDGDEWKIEMFLRD KKSGAVEFFDGLKSLKKSWQAYSDKIAREQDRFHRTVPWLSFDSGTTLISEEEAWIFL SEASETLVDMGVEILLPSWWQIVRDSNMMLKAKVSSSPRGESFVGMNALLDFNWRFAT NGIELTEAEFNELVASNRRLVNIRGQWVKIDPQFIKQMKRLMEKAESEGLHMSDILAR ELMDQQDGGLEDSDLIDTSAFAGIQFDLSKQLRSLIRKLTAAENLPEHKVSPSFKGTL RPYQKYGMNWLLFLRESGFGACLADDMGLGKTIQMIAYFLHVKESGRQKTPHLIIAPT SVLGNWQRELQTFAPDLSVALHYGPRRPKGDDFAAHYENADVVLTSYGLSHADTEELS SVTWNTICLDEAQNIKNAHTKQSRAIRKLKGLHHIALSGTPMENRLTELWSIFDFMNK GYLGSLTGFHKRYVLPIEKDRDEKRIGQLQQLIRPFLLRRTKRDEEVALNLPEKLEEK EFIPLSAEQASLYEQLVKDTFDHMTSLTGMQRKALILSMLGRLKQICDHPALYLKEEQ TELLAGRSVKLEKLLELMTAIRAQNESCLIFTQYIQMGNMMKRLLEKTFGEPVQFLNG SLSKQERDTLVEKFQRKEYPTLILSLKAGGTGLNLTAANHVIHYDRWWNPAVENQATD RAYRIGQERFVHVHKMITTGTIEEKIDVMLESKQTLNDQIIQSENWITELSTQELEEL FTLSATAQ*" gene 3555956..3558724 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" downshifts complement(3558773) /Source="Nicolas_upshifts" /id="D1876" /incds=0 /nref=9 /ntot=202 /MaxReadThrough="1.80101" /MaxDrop="4.14573" /score="30.708119" /energy="-14.4" /TU="U2843" /idTUdmin="U2844" /TUdmin=12 /isTUend="TRUE" CDS complement(3558850..3559707) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25848029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase of unidentified specificity (possibly promiscuous)" /protein_id="NP_391510.1" /db_xref="EnsemblGenomes-Gn:BSU36290" /db_xref="EnsemblGenomes-Tr:CAB15646" /db_xref="GOA:P94592" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:1NRW" /db_xref="SubtiList:BG12504" /db_xref="UniProtKB/Swiss-Prot:P94592" /translation="MKLIAIDLDGTLLNSKHQVSLENENALRQAQRDGIEVVVSTGRA HFDVMSIFEPLGIKTWVISANGAVIHDPEGRLYHHETIDKKRAYDILSWLESENYYYE VFTGSAIYTPQNGRELLDVELDRFRSANPEADLSVLKQAAEVQYSQSGFAYINSFQEL FEADEPIDFYNILGFSFFKEKLEAGWKRYEHAEDLTLVSSAEHNFELSSRKASKGQAL KRLAKQLNIPLEETAAVGDSLNDKSMLEAAGKGVAMGNAREDIKSIADAVTLTNDEHG VAHMMKHLL*" gene complement(3558850..3559707) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" CDS complement(3559713..3560489) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11491085" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11491085; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (glucose repression ofcatabolic operons)" /protein_id="NP_391511.1" /db_xref="EnsemblGenomes-Gn:BSU36300" /db_xref="EnsemblGenomes-Tr:CAB15647" /db_xref="GOA:P94591" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12503" /db_xref="UniProtKB/Swiss-Prot:P94591" /translation="MYQEERLVAILDFLKQHNRITTEQICTLLQVSRDTARRDLVKLE EQNAIIRTRGGAILPTVHQKIQSYSGRLKTVSEEKNKIGRLAASLIHDGDRVILDAST TVQACAKHLNAVDCTVITNSINLADVLSDKEGIEIYLLGGKLEKEHRFLYGSSVIEKL SSYHVDKALIGVVGISEHGITIAHEEDGMVKRKMIQQAKQVIALADHSKLGSTSFYQY AELNEIDLLITDRLPNQAFCDLLDRNGVELLVTEQDEGKD*" gene complement(3559713..3560489) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" promotor_-10 complement(3560515..3560534) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3560537) /Source="Nicolas_upshifts" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" S_feature complement(3560539..3560611) /Source="Nicolas_S_feature" /locus_tag="new_3740032_3740104_c" /HighExp="C30, GM 150, T-4.40H, G/S, C90, S2, T-5.40H, T-3.40H, T-2.40H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1398" promotor_-35 complement(3560549..3560556) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3560613..3560712) /Source="Nicolas_S_feature" /locus_tag="new_3740106_3740205_c" /HighExp="HiOs, S2, T-3.40H, T0.30H, C90, G/S, T1.0H, T0.0H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1399" downshifts complement(3560656) /Source="Nicolas_upshifts" /id="D1877" /incds=0 /nref=221 /ntot=258 /MaxReadThrough="3.81096" /MaxDrop="7.17295" /score="-7.00620083" /energy="-7.5" /TU="U2844" /idTUdmin="U2846" /TUdmin="-1" /isTUend="TRUE" CDS complement(3560713..3561054) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762004, 16009133, 16549871, 17630974, 25138221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762004, 16009133, 16549871, 17630974, 25138221; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391512.2" /db_xref="EnsemblGenomes-Gn:BSU36310" /db_xref="EnsemblGenomes-Tr:CAB15648" /db_xref="GOA:C0SPB6" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="PDB:3VDY" /db_xref="SubtiList:BG12502" /db_xref="UniProtKB/Swiss-Prot:C0SPB6" /translation="MFNQVMLVGRLTKDPDLRYTSAGAAVAHVTLAVNRSFKNASGEI EADYVNCTLWRKTAENTALYCQKGSLVGVSGRIQTRSYENEEGVNVYVTEVLADTVRF MDPKPREKAAD*" gene complement(3560713..3561054) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" promotor_-10 complement(3561076..3561095) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3561095) /Source="Nicolas_upshifts" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" promotor_-35 complement(3561109..3561116) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3561131..3561514) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="interaction partner of DynA" /protein_id="NP_391513.1" /db_xref="EnsemblGenomes-Gn:BSU36320" /db_xref="EnsemblGenomes-Tr:CAB15649" /db_xref="SubtiList:BG12501" /db_xref="UniProtKB/Swiss-Prot:P94589" /translation="MNQFRLKEIYIDGVPSESHLIQKEVTYMLSRKEVFEVHLNKKGR ISFLYETQDGMEQYKIKLSMPEKKLSFQWFAWDGSSYVRMNTQNWLTKQIFFRFLKST YFFKGKKQKMFLAEGKMKTKDKNRG*" gene complement(3561131..3561514) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" promotor_-10 complement(3561536..3561555) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-10" misc_feature 3561543..3561562 /Source="Nicolas_upshift_promotors" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3561547 /Source="Nicolas_upshifts" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(3561556) /Source="Nicolas_upshifts" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" promotor_-35 complement(3561570..3561577) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-35" misc_feature 3561637..3561656 /Source="Nicolas_upshift_promotors" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3561640 /Source="Nicolas_upshifts" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" downshifts complement(3561689) /Source="Nicolas_upshifts" /id="D1878" /incds=0 /nref=2 /ntot=169 /MaxReadThrough="0.85282" /MaxDrop="4.02798" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2846" /TUdmin="-1034" /isTUend="FALSE" CDS 3561689..3562099 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25663006" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391514.1" /db_xref="EnsemblGenomes-Gn:BSU36330" /db_xref="EnsemblGenomes-Tr:CAB15650" /db_xref="InterPro:IPR025573" /db_xref="SubtiList:BG12500" /db_xref="UniProtKB/Swiss-Prot:P94588" /translation="MKTFKLVDLNVERVDKEEQSIEQFPLIDGLIINKEDGENHWLIE ALVQKEHLSFFEQLQNSQSEAKVFVTITKKSNRPAQLTAAVKNIVKLEESIQVLLYGQ MVTRKQQGTETILESLVKEGYTGTKLIEAFKQKL*" gene 3561689..3562099 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" S_feature 3562100..3562183 /Source="Nicolas_S_feature" /locus_tag="new_3741593_3741676" /HighExp="BC, LBGtran, T3.30H, Etha, T2.0H, Lbtran, M9-stat, T3.0H, dia5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1400" downshifts 3562141 /Source="Nicolas_upshifts" /id="D1879" /incds=0 /nref=214 /ntot=260 /MaxReadThrough="1.83981" /MaxDrop="6.19197" /score="18.4023831" /energy="-14" /TU="NA" /idTUdmin="U2847" /TUdmin=0 /isTUend="TRUE" CDS complement(3562239..3562547) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 21800427, 21906378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sortase" /protein_id="NP_391515.1" /db_xref="EnsemblGenomes-Gn:BSU36340" /db_xref="EnsemblGenomes-Tr:CAB15651" /db_xref="GOA:P94587" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG12499" /db_xref="UniProtKB/Swiss-Prot:P94587" /translation="MRRDQKMGEGNYPLAGHHLKQKNLLFGPLENIKTGAQIVITDFK KDYIYSVTSKDIISEMDADVVEETNKKEITLITCDKAVKTEGRLVVKGELVDSFGHTN *" gene complement(3562239..3562547) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" downshifts complement(3562240) /Source="Nicolas_upshifts" /id="D1880" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="0.11027" /MaxDrop="2.8132" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2849" /TUdmin=1540 /isTUend="FALSE" CDS 3562891..3563727 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16740923; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative two-component sensor histidine kinase" /protein_id="NP_391516.1" /db_xref="EnsemblGenomes-Gn:BSU36350" /db_xref="EnsemblGenomes-Tr:CAB15652" /db_xref="GOA:P94586" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12498" /db_xref="UniProtKB/Swiss-Prot:P94586" /translation="MKIRERFSMVDLPVLIITAAIIGHDKYKAFHAGANDILQKPYHY SEFMARIQNLIMMKHTANQATRMEMAFLQSQIKPHFLYNVLNTIISLTHLDIEKAREV TEEFTNYLRMSFDFQNTSAISSFRHELSIINSYLSIEKTRFSNRLEVLFDIDEDIDFI LPPLMIQPLVENAVLHGVSKKRGGGWIKLTAKKQSKNEYHIKVEDNGPGITPEKQIDL LSTDFDRSVGLKNINQRLKHFCGSELMISSTPDAGTSVSMLIHLAETTGSPKELKDTE RT*" gene 3562891..3563727 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" promotor_-35 3563107..3563114 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3563129..3563148 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3563132 /Source="Nicolas_upshifts" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 3563726 /Source="Nicolas_upshifts" /id="D1881" /incds=0 /nref=13 /ntot=132 /MaxReadThrough="0.11837" /MaxDrop="3.37937" /score="9.16906941" /energy="-8.6" /TU="NA" /idTUdmin="U2848" /TUdmin=154 /isTUend="FALSE" CDS complement(3563774..3564166) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" /function="16.1: Circulate" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12948773, 15063854, 15165739, 16897034, 22685134, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12948773, 15063854, 15165739, 16897034, 22685134, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="large conductance mechanosensitive channel protein" /protein_id="NP_391517.1" /db_xref="EnsemblGenomes-Gn:BSU36360" /db_xref="EnsemblGenomes-Tr:CAB15653" /db_xref="GOA:P94585" /db_xref="InterPro:IPR001185" /db_xref="InterPro:IPR019823" /db_xref="InterPro:IPR036019" /db_xref="SubtiList:BG12497" /db_xref="UniProtKB/Swiss-Prot:P94585" /translation="MWNEFKAFAMRGNIVDLAIGVVIGGAFGKIVTSLVNDIIMPLVG LLLGGLDFSGLSFTFGDAVVKYGSFIQTIVNFLIISFSIFIVIRTLNGLRRKKEAEEE AAEEAVDAQEELLKEIRDLLKQQAKSPE*" gene complement(3563774..3564166) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" downshifts complement(3563780) /Source="Nicolas_upshifts" /id="D1882" /incds=0 /nref=216 /ntot=255 /MaxReadThrough="2.23487" /MaxDrop="6.5103" /score="28.9904077" /energy="-11.4" /TU="NA" /idTUdmin="U2849" /TUdmin=0 /isTUend="TRUE" CDS complement(3564239..3564664) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" /EC_number="4.2.1.59" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8910376, 12682299, 15194690, 15371447, 18093984, 22580319, 23322253, 27874013; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacyl-[acyl carrier protein] dehydratase" /protein_id="NP_391518.2" /db_xref="EnsemblGenomes-Gn:BSU36370" /db_xref="EnsemblGenomes-Tr:CAB15654" /db_xref="GOA:P94584" /db_xref="InterPro:IPR010084" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12496" /db_xref="UniProtKB/Swiss-Prot:P94584" /translation="MLDTQQIKEIIPHRYPFLLVDRITEVEEGKRAKGYKNVTANEEF FNGHFPQYPVMPGVLIVEALAQVGAVAMLIKEENRGRLAFFAGIDNCRFKKQVKPGDQ LHLEVEIIRARGTIGRGKGVATVDGEVVCEVELTFALGE*" gene complement(3564239..3564664) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" promotor_-10 complement(3564725..3564744) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3564741) /Source="Nicolas_upshifts" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" S_feature complement(3564743..3564827) /Source="Nicolas_S_feature" /locus_tag="new_3744236_3744320_c" /HighExp="Diami, dia5, Cold, dia15, H2O2, C30, Etha, Oxctl, Paraq, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigD, SigA" /TUlongPSig="0.999, 0.837" /label="S1401" promotor_-35 complement(3564759..3564766) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3564806 /Source="Nicolas_upshifts" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" misc_feature 3564809..3564828 /Source="Nicolas_upshift_promotors" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3564819..3564838) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-10" upshifts complement(3564827) /Source="Nicolas_upshifts" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" S_feature complement(3564829..3565913) /Source="Nicolas_S_feature" /locus_tag="new_3744322_3745406_c" /HighExp="Cold, C30, Lbstat, Glucon, Glu, Paraq, Pyr, H2O2, Fru, C90" /AntisenseName="rapD" /AntisenseCor="5.8390464430913601E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.837" /label="S1402" promotor_-35 complement(3564852..3564857) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-35" CDS 3564856..3565920 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391519.1" /db_xref="EnsemblGenomes-Gn:BSU36380" /db_xref="EnsemblGenomes-Tr:CAB15655" /db_xref="GOA:P94583" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11967" /db_xref="UniProtKB/Swiss-Prot:P94583" /translation="MISKFIEKRMLNMLDEWYSAMSKRKMNHVCTLKEKIDQHLPKIK KNTKLWMRYQLFQARHQLLFENQNGLDSLFDGLYGLEDKMDDELKYYLYFFSGLYEMV KTAPKHAVHHFKKAEQYLAAIHNTFEAADLYYQTAGAYYLMKSPPLSVQYVKKALHIY LHQFGYIKKVITCKLLLAVNYIDQERYEKAEQLFKEIIKKTQQLHDENLLCHAYYNLG FLKATEKKDQEALLYFRKVLKNQEFEMNSPVSYLHCVYESVRALFKTGNITEAKAVLQ KGKELSEKVDIQTIYLKLKTLEALYTSAEDPYEQLLEYVLELEKIEAWVDLEVLLEDI TEYYKKKDDFEKAAFFIMRG*" gene 3564856..3565920 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" S_feature 3565921..3566805 /Source="Nicolas_S_feature" /locus_tag="new_3745414_3746298" /HighExp="M9-stat, T4.0H, T2.0H, T3.30H, T2.30H, T3.0H, T1.30H, T5.0H, T1.0H, T0.30H" /AntisenseName="flhP" /AntisenseCor="-0.32116112580252298" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1403" CDS complement(3565943..3566752) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar hook-basal body accessory protein" /protein_id="NP_391520.2" /db_xref="EnsemblGenomes-Gn:BSU36390" /db_xref="EnsemblGenomes-Tr:CAB15656" /db_xref="GOA:P39753" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="InterPro:IPR020013" /db_xref="SubtiList:BG10918" /db_xref="UniProtKB/Swiss-Prot:P39753" /translation="MLRSMLTASTTLNQLQQQIDTISSNLSNSNTTGYKAKDTNFSEL VRQQFDQVDEKNEEVAKARKTPPGLRLGVGAMMSSRLVSDQGSIQKTDRDLDIAFTSP YQYLQVNVNGNRQYTRDGALYVTPSAANANQLQLVTGNGYPVLDENGNTVNIDSSMKN ITINKNGTLTASDGNAVQRFNLGVVQVNNPQELKSEGNNLFSIDNAAAFEELNGANRQ NIGMQQGSLEMSNVDISEQMTDLITSQRSYQLNSRTITMGDQMLGLINSVR*" gene complement(3565943..3566752) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" downshifts complement(3565958) /Source="Nicolas_upshifts" /id="D1883" /incds=0 /nref=174 /ntot=256 /MaxReadThrough="4.65461" /MaxDrop="5.56507" /score="8.59904552" /energy="-7.4" /TU="U2853" /idTUdmin="U2854" /TUdmin=1 /isTUend="TRUE" CDS complement(3566786..3567598) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1905667, 16621824, 22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905667, 16621824, 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal-body accessory rod protein" /protein_id="NP_391521.1" /db_xref="EnsemblGenomes-Gn:BSU36400" /db_xref="EnsemblGenomes-Tr:CAB15657" /db_xref="GOA:P39752" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10917" /db_xref="UniProtKB/Swiss-Prot:P39752" /translation="MLKGLYTATSAMIAQQRRTEMLSNNIANANTSGYKADQGSMRAF PEMLLSRIESKSPAGTSRTEIGSVNTGVYMQELKPLFTQGSLKSTDQPTDIALIENQV PMSAETNEKAALFYPVQTADGIRYSKSSTFSLNENNQLTINGRPILSTDRQPITVDNE NFTVSENGTVTTNGRTAGQIDVRMAEDVRNLKRDGNDLYSTADGNDLPSAAGNNQVAY SLKQGVSELSNVDVTSAYTEMTEAYRSFEANQKVIQAYDKSMDKAANEIGKI*" gene complement(3566786..3567598) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" S_feature complement(3567599..3567678) /Source="Nicolas_S_feature" /locus_tag="new_3747092_3747171_c" /HighExp="C90, Lbtran, Cold, GM-0.2, GM 15, GM 10, C30, GM 90, GM-0.1, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.999, 0.837" /TUlongSig="NA" /TUlongPSig="NA" /label="S1404" promotor_-35 3567629..3567636 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3567650..3567669 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3567659 /Source="Nicolas_upshifts" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3567672..3567690) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-10" upshifts complement(3567678) /Source="Nicolas_upshifts" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" promotor_-35 complement(3567704..3567711) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-35" CDS complement(3567761..3568762) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="MreB-like morphogen" /protein_id="NP_391522.2" /db_xref="EnsemblGenomes-Gn:BSU36410" /db_xref="EnsemblGenomes-Tr:CAB15658" /db_xref="GOA:P39751" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10916" /db_xref="UniProtKB/Swiss-Prot:P39751" /translation="MFARDIGIDLGTANVLIHVKGKGIVLNEPSVVALDKNSGKVLAV GEEARRMVGRTPGNIVAIRPLKDGVIADFEVTEAMLKHFINKLNVKGLFSKPRMLICC PTNITSVEQKAIKEAAEKSGGKHVYLEEEPKVAAIGAGMEIFQPSGNMVVDIGGGTTD IAVISMGDIVTSSSIKMAGDKFDMEILNYIKREYKLLIGERTAEDIKIKVATVFPDAR HEEISIRGRDMVSGLPRTITVNSKEVEEALRESVAVIVQAAKQVLERTPPELSADIID RGVIITGGGALLNGLDQLLAEELKVPVLVAENPMDCVAIGTGVMLDNMDKLPKRKLS* " gene complement(3567761..3568762) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" downshifts complement(3567767) /Source="Nicolas_upshifts" /id="D1884" /incds=0 /nref=108 /ntot=240 /MaxReadThrough="5.6154" /MaxDrop="4.18076" /score="20.122637" /energy="-11.2" /TU="U2854" /idTUdmin="U2855" /TUdmin="-1" /isTUend="TRUE" misc_feature complement(3568817..3568836) /Source="Nicolas_upshift_promotors" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3568841) /Source="Nicolas_upshifts" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" S_feature complement(3568843..3568927) /Source="Nicolas_S_feature" /locus_tag="new_3748336_3748420_c" /HighExp="S5, S6, S4, S7, S8, S3, B36, T5.0H, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1405" CDS complement(3568928..3569209) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9023218, 9324264, 15598884, 22720735, 24584501" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023218, 9324264, 15598884, 22720735, 24584501; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (stage III sporulation)" /protein_id="NP_391523.1" /db_xref="EnsemblGenomes-Gn:BSU36420" /db_xref="EnsemblGenomes-Tr:CAB15659" /db_xref="GOA:P15281" /db_xref="InterPro:IPR014208" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="PDB:2L0K" /db_xref="SubtiList:BG10408" /db_xref="UniProtKB/Swiss-Prot:P15281" /translation="MHDYIKERTIKIGKYIVETKKTVRVIAKEFGVSKSTVHKDLTER LPEINPDLANEVKEILDYHKSIRHLRGGEATKLKYKKDEILEGEPVQQS*" gene complement(3568928..3569209) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" CDS complement(3569224..3569334) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9023218; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative factor required for translation of spoIIID" /protein_id="NP_391524.1" /db_xref="EnsemblGenomes-Gn:BSU36430" /db_xref="EnsemblGenomes-Tr:CAB15660" /db_xref="SubtiList:BG11984" /db_xref="UniProtKB/Swiss-Prot:O32276" /translation="MGIFHKLTFKTIQRRSGIMNDSLQNTDLISHFSHPF*" gene complement(3569224..3569334) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" promotor_-10 complement(3569365..3569383) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3569387) /Source="Nicolas_upshifts" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" promotor_-35 complement(3569399..3569404) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3569480..3569486 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3569500..3569519 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3569516 /Source="Nicolas_upshifts" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" CDS 3569559..3569972 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391525.1" /db_xref="EnsemblGenomes-Gn:BSU36440" /db_xref="EnsemblGenomes-Tr:CAB15661" /db_xref="GOA:P94578" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12495" /db_xref="UniProtKB/Swiss-Prot:P94578" /translation="MSYVNRHLIHQINQSARLIAKKANEQLEPFGLYSSQWSVLYCLR TIGPMTQKEIWSYLNVEAPTVTRTIKRLEENGWVQRRQGEDKREKLVVLTKEAEKKYE EINVKMLKFEEELLADFRDEDKEAFSHLFRMFLQQ*" gene 3569559..3569972 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" CDS 3569994..3571184 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391526.1" /db_xref="EnsemblGenomes-Gn:BSU36450" /db_xref="EnsemblGenomes-Tr:CAB15662" /db_xref="GOA:P94577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12494" /db_xref="UniProtKB/Swiss-Prot:P94577" /translation="MKKADAIWTKDFIMVLLVNLFVFVFFYTFLTVLPIYTLQELGGT ESQGGLLISLFLLSAIITRPFSGAIVERFGKKRMAIVSMALFALSSFLYMPIHNFSLL LGLRFFQGIWFSILTTVTGAIAADIIPAKRRGEGLGYFAMSMNLAMAIGPFLGLNLMR VVSFPVFFTAFALFMVAGLLVSFLIKVPQSKDSGTTVFRFAFSDMFEKGALKIATVGL FISFCYSTVTSYLSVFAKSVDLSDISGYFFVCFAVTMMIARPFTGKLFDKVGPGIVIY PSILIFSVGLCMLSFTHSGLMLLLSGAVIGLGYGSIVPCMQTLAIQKSPAHRSGFATA TFFTFFDSGIAVGSYVFGLFVASAGFSAIYLTAGLFVLIALLLYTWSQKKPAEAEGKV SIAE*" gene 3569994..3571184 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" CDS complement(3571275..3572681) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15266115, 16607952, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pectin lyase" /protein_id="NP_391527.1" /db_xref="EnsemblGenomes-Gn:BSU36460" /db_xref="EnsemblGenomes-Tr:CAB15663" /db_xref="GOA:P94576" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR006633" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12493" /db_xref="UniProtKB/Swiss-Prot:P94576" /translation="MRKWYFILLAGVLTSVILAFVYDKTKANEEGSGDYLYVSPNGSD QNEGTKEKPFRTLAHASEKAAAGTTVMIREGTYHETLDVKHSGTDGKPITFRNYENEN VVISGESVANAEYETPLIRIHDKHDIAISGLTIQDLSVSSEEATAIGIYVSGSSSHIA IKDNHIRGIKTTADEGNAHGIAVYGTGSMKDIRIEDNTVEKLTLGASEAVVLNGNIDG FTVAGNVVRNNNNIGIDLIGYEGTADKNDYVRNGVVENNTVYQNSTYGNPAYGDEYSA GGIYVDGGHDIEIKNNTVYDNDIGIEATSEHKGKYANAIQITDNKVYNNAYTGISIGG YDKKRGGTSNSLIARNIMYRNDTKGLYGGQLLLQYDTKNNTIEKNILTAGDSRLFIGN DFTENEGNTVNHNVYHKEADQDGIWMWKKKEYDSFSSYRKATKNDQQSIYADPMFRDE ASYDFSLDPDSPARPVIE*" gene complement(3571275..3572681) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" downshifts complement(3571572) /Source="Nicolas_upshifts" /id="D1885" /incds=1 /nref=1 /ntot=78 /MaxReadThrough="5.28695" /MaxDrop="2.1962" /score="4.73902293" /energy="-22.3" /TU="U2857" /idTUdmin="U2857" /TUdmin="-924" /isTUend="FALSE" promotor_-10 complement(3572714..3572733) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3572732) /Source="Nicolas_upshifts" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" promotor_-35 complement(3572748..3572751) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3572787..3574259) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 15849754, 16850406, 26967546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 15849754, 16850406, 26967546; Product type t : transporter" /codon_start=1 /transl_table=11 /product="allantoin permease" /protein_id="NP_391528.1" /db_xref="EnsemblGenomes-Gn:BSU36470" /db_xref="EnsemblGenomes-Tr:CAB15664" /db_xref="GOA:P94575" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR012681" /db_xref="SubtiList:BG12492" /db_xref="UniProtKB/Swiss-Prot:P94575" /translation="MKLKESQQQSNRLSNEDLVPLGQEKRTWKAMNFASIWMGCIHNI PTYATVGGLIAIGLSPWQVLAIIITASLILFGALALNGHAGTKYGLPFPVIIRASYGI YGANIPALLRAFTAIMWLGIQTFAGSTALNILLLNMWPGWGEIGGEWNILGIHLSGLL SFVFFWAIHLLVLHHGMESIKRFEVWAGPLVYLVFGGMVWWAVDIAGGLGPIYSQPGK FHTFSETFWPFAAGVTGIIGIWATLILNIPDFTRFAETQKEQIKGQFYGLPGTFALFA FASITVTSGSQVAFGEPIWDVVDILARFDNPYVIVLSVITLCIATISVNVAANIVSPA YDIANALPKYINFKRGSFITALLALFTVPWKLMESATSVYAFLGLIGGMLGPVAGVMM ADYFIIRKRELSVDDLYSETGRYVYWKGYNYRAFAATMLGALISLIGMYVPVLKSLYD ISWFVGVLISFLFYIVLMRVHPPASLAIETVEHAQVRQAE*" gene complement(3572787..3574259) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" CDS complement(3574440..3575798) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391529.1" /db_xref="EnsemblGenomes-Gn:BSU36480" /db_xref="EnsemblGenomes-Tr:CAB15665" /db_xref="GOA:P94574" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12491" /db_xref="UniProtKB/Swiss-Prot:P94574" /translation="MLSKKSRAVFLTAVASGTMLNPLNSSMISLALHSIQHEFHLSFT TVSWLISSFYLASAVAQPVTGKLGDLIGRKRLFLFGLILVAVSAIGAPFAPTFMTLLV MRLFQSVGSSAIYPSGVGLIRNHIHERQASALAVLSIFASAMTALGPTAGGFLIVWGG WPAIFIVNLPFIILSFLLGLYMFPKDQKKGAGIKTIIRQLDILGIVLFAGGIIFLLSF LLSFSTSPHAVEGVLGLLLLCAFVWRELKTDKPFIDVRLFKTQRNLSAVYVQFILLNV FFYCLFFGLPSYFQDEMHLSVQTSGLFMLFMSGMSIVVSPLTGKWIDRSGVVKPIFAG ALLMTAGAVLLTIFFINVQTIGKGLILSLLGIGYGLGNVALQAAMLETSPSNMVGTTS GLFQTCRYLGSILSSVILGILFGKEITAAHFDMMGIIMIIAGGASLLMAVRFAALMKT AS*" gene complement(3574440..3575798) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" downshifts complement(3574454) /Source="Nicolas_upshifts" /id="D1886" /incds=0 /nref=58 /ntot=198 /MaxReadThrough="1.44148" /MaxDrop="4.13092" /score="20.2036192" /energy="-12.8" /TU="NA" /idTUdmin="U2858" /TUdmin=0 /isTUend="TRUE" CDS complement(3575798..3576367) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme of isochorismatase family" /protein_id="NP_391530.2" /db_xref="EnsemblGenomes-Gn:BSU36490" /db_xref="EnsemblGenomes-Tr:CAB15666" /db_xref="GOA:P94573" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12490" /db_xref="UniProtKB/Swiss-Prot:P94573" /translation="MMNTLNIDFQKTALVIIDLQKGIVPIDQSGQVVPNAKKLVDEFR KHNGFISFVNVAFHDGADALKPQTDEPAQGGSGEMPADWAEFVPEIGVQDGDYTVTKR QWGAFFGTDLDLQLRRRGIDTIVLCGIATNIGVESTAREAFQLGYQQIFITDAMSTFS DEEHEATLRFIFPRIGKSRTTEEFLEQVK*" gene complement(3575798..3576367) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" promotor_-10 complement(3576386..3576397) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3576404) /Source="Nicolas_upshifts" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" promotor_-35 complement(3576411..3576417) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3576474..3576641) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CCQ48605.1" /translation="MSYPALDGPPQIHGHFQAGTDRQQAGDEAMTPFMITVLAGLFVC TTCYYYIKEKS*" gene complement(3576474..3576641) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /pseudo CDS complement(3576551..3577015) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21856850; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391531.1" /db_xref="EnsemblGenomes-Gn:BSU36500" /db_xref="EnsemblGenomes-Tr:CAB15667" /db_xref="GOA:P94572" /db_xref="InterPro:IPR020218" /db_xref="SubtiList:BG12489" /db_xref="UniProtKB/Swiss-Prot:P94572" /translation="MMNKGGRLRKAVRKSIPATFRLFLAFNFFVYGLAKVVIGQFGEV TPEIEAAAGKGFTIAWTFFGYSHVYELFIGFGEILAAVLLLIPRTAALGAVIFMPIIV NIVLINYCFDIGVQDLSTILMVMCLILLWMDRRKFMGIFRQEPIDSRQVMKR*" gene complement(3576551..3577015) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" promotor_-10 complement(3577045..3577064) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3577050) /Source="Nicolas_upshifts" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" promotor_-35 complement(3577078..3577085) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3577216..3577219 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3577234..3577253 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3577238 /Source="Nicolas_upshifts" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" CDS 3577297..3578511 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 15849754, 16850406, 17001076, 21435182" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 15849754, 16850406, 17001076, 21435182; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ammonium transporter" /protein_id="NP_391532.1" /db_xref="EnsemblGenomes-Gn:BSU36510" /db_xref="EnsemblGenomes-Tr:CAB15668" /db_xref="GOA:Q07429" /db_xref="InterPro:IPR001905" /db_xref="InterPro:IPR018047" /db_xref="InterPro:IPR024041" /db_xref="InterPro:IPR029020" /db_xref="SubtiList:BG10869" /db_xref="UniProtKB/Swiss-Prot:Q07429" /translation="MQMGDTVFMFFCALLVWLMTPGLALFYGGMVKSKNVLSTAMHSF SSIAIVSIVWVLFGYTLAFAPGNSIIGGLEWAGLKGVGFDPGDYSDTIPHSLFMMFQM TFAVLTTAIISGAFAERMRFGAFLLFSVLWASLVYTPVAHWVWGGGWIGQLGALDFAG GNVVHISSGVAGLVLAIVLGKRKDGTASSPHNLIYTFLGGALIWFGWFGFNVGSALTL DGVAMYAFINTNTAAAAGIAGWILVEWIINKKPTMLGAVSGAIAGLVAITPAAGFVTP FASIIIGIIGGAVCFWGVFSLKKKFGYDDALDAFGLHGIGGTWGGIATGLFATTSVNS AGADGLFYGDASLIWKQIVAIAATYVFVFIVTFVIIKIVSLFLPLRATEEEESLGLDL TMHGEKAYQDSM*" gene 3577297..3578511 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" promotor_-10 complement(3578127..3578145) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3578128) /Source="Nicolas_upshifts" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3578159..3578166) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3578377..3578383 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3578397..3578416 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3578399 /Source="Nicolas_upshifts" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" CDS 3578523..3578873 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 17001076, 21435182, 23461034, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen-regulated PII-like regulator protein" /protein_id="NP_391533.1" /db_xref="EnsemblGenomes-Gn:BSU36520" /db_xref="EnsemblGenomes-Tr:CAB15669" /db_xref="GOA:Q07428" /db_xref="InterPro:IPR002187" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017918" /db_xref="PDB:4R25" /db_xref="PDB:4RX6" /db_xref="SubtiList:BG10870" /db_xref="UniProtKB/Swiss-Prot:Q07428" /translation="MSGQMFKVEIVTRPANFEKLKQELGKIGVTSLTFSNVHGCGLQK AHTELYRGVKIESNVYERLKIEIVVSKVPVDQVTETAKRVLKTGSPGDGKIFVYEISN TINIRTGEEGPEAL*" gene 3578523..3578873 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" downshifts 3578866 /Source="Nicolas_upshifts" /id="D1887" /incds=0 /nref=179 /ntot=251 /MaxReadThrough="2.13701" /MaxDrop="8.63831" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2860" /TUdmin=0 /isTUend="TRUE" promotor_-35 3578925..3578933 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3578947..3578955 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3578954 /Source="Nicolas_upshifts" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" promotor_-35 3578996..3579005 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3579018..3579033 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3579022 /Source="Nicolas_upshifts" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" CDS 3579054..3579635 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" /EC_number="3.6.1.27" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate phosphatase (bacitracin resistance)" /protein_id="NP_391534.1" /db_xref="EnsemblGenomes-Gn:BSU36530" /db_xref="EnsemblGenomes-Tr:CAB15670" /db_xref="GOA:P94571" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR033879" /db_xref="InterPro:IPR036938" /db_xref="SubtiList:BG12488" /db_xref="UniProtKB/Swiss-Prot:P94571" /translation="MNYEIFKAIHGLSHHNSVLDSIMVFITEYAIVAYALILLAIWLF GNTQSRKHVLYAGITGIAGLVINYLITLVYFEPRPFVAHTVHTLIPHAADASFPSDHT TGALAISIAMLFRNRKIGWPLVIFGLLTGFSRIWVGHHYPVDVLGSLVVAIIIGFLFF RFSDLLRPFVDLVVRIYEAIINKLTKKPTDQNF*" gene 3579054..3579635 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" promotor_-10 complement(3579152..3579171) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3579162) /Source="Nicolas_upshifts" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3579185..3579193) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3579616 /Source="Nicolas_upshifts" /id="D1888" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.1929" /MaxDrop="6.53316" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2863" /TUdmin=2 /isTUend="TRUE" CDS complement(3579676..3580098) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14762009, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391535.1" /db_xref="EnsemblGenomes-Gn:BSU36540" /db_xref="EnsemblGenomes-Tr:CAB15671" /db_xref="GOA:P71045" /db_xref="InterPro:IPR006976" /db_xref="SubtiList:BG12487" /db_xref="UniProtKB/Swiss-Prot:P71045" /translation="MNRLLLAGWIFFILLSVCTESFSGMVVSQTVAFHFQPHPDLSQF LVMDFTELTVPEAFIQKIGHAFSFFVLTYLLWKQRGSIRSAAAGSFAFAFFTEVLQLF FSRNGCIRDVLIDAVGIGLFYGLYVLAKRRKQEMYEKY*" gene complement(3579676..3580098) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" downshifts complement(3579695) /Source="Nicolas_upshifts" /id="D1889" /incds=0 /nref=9 /ntot=75 /MaxReadThrough="0.80227" /MaxDrop="3.65224" /score="4.98901321" /energy="-13.6" /TU="NA" /idTUdmin="U2869" /TUdmin=215 /isTUend="FALSE" promotor_-10 complement(3580133..3580148) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3580152) /Source="Nicolas_upshifts" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" promotor_-35 complement(3580161..3580170) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3580209..3581060) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" /function="16.8: Protect" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore protein required for alternative engulfment" /protein_id="NP_391536.1" /db_xref="EnsemblGenomes-Gn:BSU36550" /db_xref="EnsemblGenomes-Tr:CAB15672" /db_xref="GOA:P71044" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11978" /db_xref="UniProtKB/Swiss-Prot:P71044" /translation="MREEEKKTSQVKKLQQFFRKRWVFPAIYLVSAAVILTAVLWYQS VSNDEVKDQLADNGGNSAYDNNDDAVEVGKSMENVAMPVVDSENVSVVKKFYETDAAK EEKEAALVTYNNTYSLSKGIDLAEKDGKDFDVSASLSGTVVKAEKDPVLGYVVEVEHA DGLSTVYQSLSEVSVEQGDKVKQNQVIGKSGKNLYSEDSGNHVHFEIRKDGVAMNPLN FMDKPVSSIEKAATQETEESIQQSSEKKDGSTEKGTEEKSGEKKDDSTDKSGSKESST TEDTEQS*" gene complement(3580209..3581060) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" downshifts complement(3580218) /Source="Nicolas_upshifts" /id="D1890" /incds=0 /nref=19 /ntot=51 /MaxReadThrough="3.592" /MaxDrop="5.16472" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-176" /isTUend="FALSE" downshifts complement(3580460) /Source="Nicolas_upshifts" /id="D1891" /incds=1 /nref=4 /ntot=59 /MaxReadThrough="6.6416" /MaxDrop="3.0034" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-418" /isTUend="FALSE" promotor_-35 3580697..3580699 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3580716..3580735 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3580717..3581063 /Source="Nicolas_S_feature" /locus_tag="new_3760210_3760556" /HighExp="LBGstat, LBGtran, Cold, Sw, dia15, C30, G180, Lbexp, LBGexp, UNK1" /AntisenseName="spoIIQ" /AntisenseCor="-0.81767802234568998" /AntisenseRegPval="-65.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1406" upshifts 3580717 /Source="Nicolas_upshifts" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" misc_feature 3581055..3581058 /Source="Nicolas_upshift_promotors" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3581065..3581200 /Source="Nicolas_S_feature" /locus_tag="new_3760558_3760693" /HighExp="LBGstat, S8, LBGtran, Sw, LoTm, BC, Cold, S7, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.122, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1407" upshifts 3581065 /Source="Nicolas_upshifts" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" upshifts complement(3581094) /Source="Nicolas_upshifts" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" misc_feature complement(3581100..3581109) /Source="Nicolas_upshift_promotors" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3581201..3581692 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" /EC_number="2.3.1.183" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 16021622, 27694229; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacid analogs (phosphinothricin) N-acetyltransferase" /protein_id="NP_391537.1" /db_xref="EnsemblGenomes-Gn:BSU36560" /db_xref="EnsemblGenomes-Tr:CAB15673" /db_xref="GOA:P71043" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1VHS" /db_xref="SubtiList:BG12486" /db_xref="UniProtKB/Swiss-Prot:P71043" /translation="MTLRLAEHRDLEAVVAIYNSTIASRMVTADTEPVTPEDRMEWFS GHTESRPLYVAEDENGNVAAWISFETFYGRPAYNKTAEVSIYIDEACRGKGVGSYLLQ EALRIAPNLGIRSLMAFIFGHNKPSLKLFEKHGFAEWGLFPGIAEMDGKRYDLKILGR ELS*" gene 3581201..3581692 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" promotor_-35 3581430..3581435 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3581451..3581469 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3581462 /Source="Nicolas_upshifts" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" S_feature complement(3581553..3582461) /Source="Nicolas_S_feature" /locus_tag="new_3761046_3761954_c" /HighExp="H2O2, dia15, Diami, dia5, S8, Paraq, G180, G135, C30, G150" /AntisenseName="ywnG" /AntisenseCor="0.27407310266030799" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S1408" CDS 3581689..3582207 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391538.1" /db_xref="EnsemblGenomes-Gn:BSU36570" /db_xref="EnsemblGenomes-Tr:CAB15674" /db_xref="GOA:P71042" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12485" /db_xref="UniProtKB/Swiss-Prot:P71042" /translation="MISLDKDENEIEHHNEENSLVEQETAPVGQESRQLSASAVKSLS DIAKWGKISGILLIIMGSLVTLSVLMTVIGAIPGVLLIISGVFLMRSAKAAAEAEGNL TGSAGESMLENYGTFIKMQLFYAASSIVTVLIGIIVAIFVLVVIGIAAFENTPSYDDP DSYYYEDDPVFE*" gene 3581689..3582207 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" downshifts 3582012 /Source="Nicolas_upshifts" /id="D1892" /incds=1 /nref=1 /ntot=29 /MaxReadThrough="4.194" /MaxDrop="1.82458" /score="-3.39058903" /energy="-13.3" /TU="U2867,U2868,U2870" /idTUdmin="U2868" /TUdmin="-44" /isTUend="FALSE" downshifts 3582210 /Source="Nicolas_upshifts" /id="D1893" /incds=0 /nref=3 /ntot=133 /MaxReadThrough="2.87136" /MaxDrop="2.9486" /score="-3.39058903" /energy="-13.3" /TU="U2867" /idTUdmin="U2870" /TUdmin=0 /isTUend="TRUE" CDS 3582366..3582497 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514007.1" /translation="MNIKKTDEVGINPKPHFLFRVSACKKTHPDRLENLNNPGADLL* " gene 3582366..3582497 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" CDS complement(3582494..3582928) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391539.1" /db_xref="EnsemblGenomes-Gn:BSU36580" /db_xref="EnsemblGenomes-Tr:CAB15675" /db_xref="GOA:P71041" /db_xref="InterPro:IPR020205" /db_xref="SubtiList:BG12484" /db_xref="UniProtKB/Swiss-Prot:P71041" /translation="MNFYRVEQMPGFIKTEMQKIQKAVQPFMKKTVIYRFLAIPLAAF SLFNLAAFLFHASADRESLISAGIFALLAALGLAFFKEAGYQHKQIQKTVHIYMLNRI KKSEILSEERKSSYARQIKEEPFAMRSFVEFLTEEDRRKKMY*" gene complement(3582494..3582928) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" downshifts complement(3582506) /Source="Nicolas_upshifts" /id="D1894" /incds=0 /nref=174 /ntot=254 /MaxReadThrough="4.22489" /MaxDrop="5.35802" /score="21.5198482" /energy="-21.3" /TU="U2871" /idTUdmin="U2873" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3582977..3582996) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3582984) /Source="Nicolas_upshifts" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" S_feature complement(3582986..3583283) /Source="Nicolas_S_feature" /locus_tag="new_3762479_3762776_c" /HighExp="Etha, S6, S3, S4, S8, S5, S7, M9-stat, Sw, Salt" /AntisenseName="clsA" /AntisenseCor="-0.16109419145114601" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF" /TUshortPSig="0.99, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1409" promotor_-35 complement(3583011..3583018) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3583057..3583061 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3583078..3583097 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3583090..3583170 /Source="Nicolas_S_feature" /locus_tag="new_3762583_3762663" /HighExp="LBGstat, Diami, dia15, G180, Oxctl, H2O2, T0.30H, S8, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1410" upshifts 3583091 /Source="Nicolas_upshifts" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" CDS 3583171..3584619 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14973018, 16755131, 18820022, 26708983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16755131, 18820022, 26708983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cardiolipin synthase (major)" /protein_id="NP_391540.1" /db_xref="EnsemblGenomes-Gn:BSU36590" /db_xref="EnsemblGenomes-Tr:CAB15676" /db_xref="GOA:P71040" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG12483" /db_xref="UniProtKB/Swiss-Prot:P71040" /translation="MSISSILLSLFFILNILLAIIVIFKERRDASASWAWLLVLFFIP VLGFILYLLFGHNLRRKHLFQWEDRKKIGIERLLKHQLEDLETKQFQFNNRATFDNKD LIYMLIMNNHAVFTEDNSVDVITDGRDKFQRLLSDISKAKDHIHLQYYIYKGDELGKK LRDALIQKAKEGVQVRVLYDELGSRTLRKKFFKELREAGGHVEVFFPSKLRPINLRLN YRNHRKLVIIDGMTGYVGGFNVGDEYLGLNPKFGYWRDTHIRLQGTAVHAIQTRFILD WNQASHHHTLTYIPNHFPDYGPKGNVGMQIVTSGPDSEWEQIKNGYIKMISNAKRSIL IQTPYFIPDASLLDALRIACLSGIDVNIMIPNKPDHAFVYWATLSYIGDLLKAGATVY IYDNGFIHAKTIVVDDEIASVGTANIDVRSFRLNFEVNAFIYDITIAKKLVSTFKEDL LVSRKFTYEEYLQRPLWIRIKESVSRLLSPIL*" gene 3583171..3584619 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" upshifts complement(3583283) /Source="Nicolas_upshifts" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" promotor_-10 complement(3583284..3583302) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(3583285..3583628) /Source="Nicolas_S_feature" /locus_tag="new_3762778_3763121_c" /HighExp="S6, S8, S4, S5, S7, S3, T5.0H, M9-stat, C30, T4.0H" /AntisenseName="clsA" /AntisenseCor="3.3648966966722899E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1411" promotor_-35 complement(3583318..3583324) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3583606..3583624) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3583628) /Source="Nicolas_upshifts" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" promotor_-35 complement(3583640..3583645) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3584608 /Source="Nicolas_upshifts" /id="D1895" /incds=0 /nref=6 /ntot=214 /MaxReadThrough="0.7051" /MaxDrop="4.44298" /score="26.7449315" /energy="-19.5" /TU="NA" /idTUdmin="U2872" /TUdmin=0 /isTUend="TRUE" CDS complement(3584640..3585413) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10200972, 11581256, 18502870" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 11581256, 18502870; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulating efflux transporters synthesis (Fur-independent bacillibactin export)" /protein_id="NP_391541.1" /db_xref="EnsemblGenomes-Gn:BSU36600" /db_xref="EnsemblGenomes-Tr:CAB15677" /db_xref="GOA:P71039" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012925" /db_xref="InterPro:IPR036244" /db_xref="PDB:1JBG" /db_xref="PDB:1R8D" /db_xref="SubtiList:BG12482" /db_xref="UniProtKB/Swiss-Prot:P71039" /translation="MKYQVKQVAEISGVSIRTLHHYDNIELLNPSALTDAGYRLYSDA DLERLQQILFFKEIGFRLDEIKEMLDHPNFDRKAALQSQKEILMKKKQRMDEMIQTID RTLLSVDGGETMNKRDLFAGLSMKDIEEHQQTYADEVRKLYGKEIAEETEKRTSAYSA DDWRTIMAEFDSIYRRIAARMKHGPDDAEIQAAVGAFRDHICQYHYDCTLDIFRGLGE VYITDERFTDSINQYGEGLAAFLREAIIIYCDHQENPRP*" gene complement(3584640..3585413) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" downshifts complement(3584662) /Source="Nicolas_upshifts" /id="D1896" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="0.46006" /MaxDrop="2.97389" /score="11.4339746" /energy="-19.5" /TU="NA" /idTUdmin="U2876" /TUdmin=1342 /isTUend="FALSE" promotor_-35 3585488..3585491 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3585507..3585526 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3585511 /Source="Nicolas_upshifts" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" CDS 3585558..3585941 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391542.1" /db_xref="EnsemblGenomes-Gn:BSU36610" /db_xref="EnsemblGenomes-Tr:CAB15678" /db_xref="GOA:P71038" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12481" /db_xref="UniProtKB/Swiss-Prot:P71038" /translation="MNPETMNKTLISISKWGKATGILFIIMGAITALSGAFFFLIGAV PGVLQIISGIFLMRSAREAGQMAEHNSGQSEDLMLENYAKFVKMQGIYLIVSIAVSIL AIIAFFIFLMLGIADGLFSDTYSTY*" gene 3585558..3585941 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" downshifts 3585928 /Source="Nicolas_upshifts" /id="D1897" /incds=0 /nref=60 /ntot=180 /MaxReadThrough="1.0319" /MaxDrop="4.45212" /score="35.5991488" /energy="-11.4" /TU="NA" /idTUdmin="U2875" /TUdmin=0 /isTUend="TRUE" CDS complement(3585976..3586617) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391543.1" /db_xref="EnsemblGenomes-Gn:BSU36620" /db_xref="EnsemblGenomes-Tr:CAB15679" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12480" /db_xref="UniProtKB/Swiss-Prot:P71037" /translation="MKIGIIGASGKAGNEILKEAKKRGHEVTAIVRNASKVQEQDVAI LEKDVFELTAEDIKPFDAVVNAFGAAPGQEHLHVEAGRALISILKDAKHTRLLVVGGA GSLFVDEAKTTRLMDTPEFPKEYLPTASNQGENLKDLQQTDSISWTFLSPAAFFDPAG KRTGSYQKGKDNVIVNAKGDSYISYADYAIAVLDELEHPEHKNERFTVVSEAE*" gene complement(3585976..3586617) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" downshifts complement(3586026) /Source="Nicolas_upshifts" /id="D1898" /incds=0 /nref=20 /ntot=170 /MaxReadThrough="3.62026" /MaxDrop="4.98934" /score="21.1363072" /energy="-11.4" /TU="U2876" /idTUdmin="U2876" /TUdmin="-22" /isTUend="TRUE" CDS complement(3586685..3587086) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391544.1" /db_xref="EnsemblGenomes-Gn:BSU36630" /db_xref="EnsemblGenomes-Tr:CAB15680" /db_xref="GOA:P71036" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1XD7" /db_xref="SubtiList:BG12479" /db_xref="UniProtKB/Swiss-Prot:P71036" /translation="MINSRLAVAIHILSLISMDEKTSSEIIADSVNTNPVVVRRMISL LKKADILTSRAGVPGASLKKDPADISLLEVYRAVQKQEELFAVHENPNPKCPVGKKIQ NALDETFESVQRAMENELASKSLKDVMNHLF*" gene complement(3586685..3587086) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" promotor_-10 complement(3587135..3587154) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3587145) /Source="Nicolas_upshifts" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" S_feature complement(3587147..3587220) /Source="Nicolas_S_feature" /locus_tag="new_3766640_3766713_c" /HighExp="BT, Etha, S1, B60, LoTm, B36, S2, Glucon, Sw, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.18507799999999999" /TUshortSig="Sig-" /TUshortPSig="0.106" /TUlongSig="SigH, SigA, SigB, SigB" /TUlongPSig="1, 0.993, 1, 0.995" /label="S1412" promotor_-35 complement(3587169..3587174) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3587221..3588930) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (alpha subunit)" /protein_id="NP_391545.1" /db_xref="EnsemblGenomes-Gn:BSU36640" /db_xref="EnsemblGenomes-Tr:CAB15681" /db_xref="GOA:P77837" /db_xref="InterPro:IPR005848" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR011612" /db_xref="InterPro:IPR017950" /db_xref="InterPro:IPR017951" /db_xref="InterPro:IPR029754" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11983" /db_xref="UniProtKB/Swiss-Prot:P77837" /translation="MKMSREEYAELFGPTTGDKIRLGDTDLWIEVEKDFTVYGEEMIF GGGKTIRDGMGQNGRITGKDGALDLVITNVVLLDYTGIVKADVGVKDGRIVGVGKSGN PDIMDGVDPHMVIGAGTEVISGEGKILTAGGVDTHIHFICPQQMEVALSSGVTTLLGG GTGPATGSKATTCTSGAWYMARMLEAAEEFPINVGFLGKGNASDKAPLIEQVEAGAIG LKLHEDWGTTPSAIKTCMEVVDEADIQVAIHTDTINEAGFLENTLDAIGDRVIHTYHI EGAGGGHAPDIMKLASYANILPSSTTPTIPYTVNTMDEHLDMMMVCHHLDAKVPEDVA FSHSRIRAATIAAEDILHDIGAISMTSSDSQAMGRVGEVIIRTWQVADKMKKQRGALA GENGNDNVRAKRYIAKYTINPAITHGLSHEVGSVEKGKLADLVLWDPVFFGVKPELVL KGGMIARAQMGDPNASIPTPEPVFMRQMYASYGKANRSTSITFMSQASIERGVAESLG LEKRISPVKNIRKLSKLDMKLNSALPKIEIDPKTYQVFADGEELSCQPVDYVPLGQRY FLF*" gene complement(3587221..3588930) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" CDS complement(3588927..3589301) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (beta subunit)" /protein_id="NP_391546.1" /db_xref="EnsemblGenomes-Gn:BSU36650" /db_xref="EnsemblGenomes-Tr:CAB15682" /db_xref="GOA:P71035" /db_xref="InterPro:IPR002019" /db_xref="InterPro:IPR036461" /db_xref="SubtiList:BG11982" /db_xref="UniProtKB/Swiss-Prot:P71035" /translation="MKPGAFQIAEGTITINEGREIREVTVKNTGSRSIQVGSHFHFAE ANGALLFDRELAIGMRLDVPSGTSVRFEPGEQKTVSLVEIRGRKTIRGLNGMADTFID ERGKEKTLANLKQAGWMEGVIR*" gene complement(3588927..3589301) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" CDS complement(3589298..3589615) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" /EC_number="3.5.1.5" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (gamma subunit)" /protein_id="NP_391547.1" /db_xref="EnsemblGenomes-Gn:BSU36660" /db_xref="EnsemblGenomes-Tr:CAB15683" /db_xref="GOA:P75030" /db_xref="InterPro:IPR002026" /db_xref="InterPro:IPR012010" /db_xref="InterPro:IPR036463" /db_xref="SubtiList:BG11981" /db_xref="UniProtKB/Swiss-Prot:P75030" /translation="MKLTPVEQEKLLIFAAGELAKQRKARGVLLNYPEAAAYITCFIM EGARDGKGVAELMEAGRHVLTEKDVMEGVPEMLDSIQVEATFPDGVKLVTVHQPISAE VKS*" gene complement(3589298..3589615) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" S_feature complement(3589616..3589700) /Source="Nicolas_S_feature" /locus_tag="new_3769109_3769193_c" /HighExp="BT, B60, B36, S1, Etha, LoTm, M9-stat, S2, T0.30H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigH, SigB" /TUshortPSig="0.106, 1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1413" upshifts complement(3589700) /Source="Nicolas_upshifts" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" misc_feature complement(3589702..3589715) /Source="Nicolas_upshift_promotors" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(3589702..3589795) /Source="Nicolas_S_feature" /locus_tag="new_3769195_3769288_c" /HighExp="BT, Etha, B60, S1, B36, BC, S2, LoTm, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30781199999999997" /TUshortSig="SigH, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1414" CDS complement(3589796..3589960) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (putative phage interference protein)" /protein_id="YP_009514008.1" /translation="MVNLKNILLNKQLEGIQILIVELVRQVIIEISRKKDICYLSRAQ SGKRVNLIFP*" gene complement(3589796..3589960) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" promotor_-10 complement(3589883..3589901) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-10" upshifts complement(3589895) /Source="Nicolas_upshifts" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" promotor_-35 complement(3589913..3589921) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-35" S_feature complement(3589961..3590132) /Source="Nicolas_S_feature" /locus_tag="new_3769454_3769625_c" /HighExp="Etha, BT, S1, GM-0.2, GM-0.1, Salt, GM 5, T-5.40H, MG 60, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1415" CDS complement(3590133..3590315) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="PSEUDO:CAX52705.1" /translation="MKAGILHSLRGTVAISEVTVHDAELMAIVGFSVSWRSAPQTGLH AMLPVAEQNNGLPSGM*" gene complement(3590133..3590315) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /pseudo S_feature complement(3590316..3590462) /Source="Nicolas_S_feature" /locus_tag="new_3769809_3769955_c" /HighExp="Etha, BT, S1, Salt, GM-0.2, GM-0.1, M9-stat, GM 5, GM 45, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15897800000000001" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1416" promotor_-10 complement(3590450..3590469) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3590462) /Source="Nicolas_upshifts" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" S_feature complement(3590464..3590577) /Source="Nicolas_S_feature" /locus_tag="new_3769957_3770070_c" /HighExp="Etha, Salt, M9-stat, S8, B60, B36, Sw, Gly, LoTm, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1417" promotor_-35 complement(3590484..3590491) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" upshifts 3590591 /Source="Nicolas_upshifts" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 3590594..3590598 /Source="Nicolas_upshift_promotors" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3590611..3590799) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10376822, 11988534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376822, 11988534; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein" /protein_id="NP_391548.1" /db_xref="EnsemblGenomes-Gn:BSU36670" /db_xref="EnsemblGenomes-Tr:CAB15684" /db_xref="InterPro:IPR008462" /db_xref="InterPro:IPR036629" /db_xref="SubtiList:BG12478" /db_xref="UniProtKB/Swiss-Prot:P70964" /translation="MGNDSVKDKMKGGFNKAKGEVKDKVGDMADRTDMQAEGKKDKAK GEIQKDIGKAKDKFSDKD*" gene complement(3590611..3590799) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" downshifts complement(3590622) /Source="Nicolas_upshifts" /id="D1899" /incds=0 /nref=69 /ntot=139 /MaxReadThrough="6.39376" /MaxDrop="6.75256" /score="21.8463823" /energy="-10.2" /TU="U2881" /idTUdmin="U2882" /TUdmin=221 /isTUend="FALSE" downshifts 3590789 /Source="Nicolas_upshifts" /id="D1900" /incds=0 /nref=15 /ntot=36 /MaxReadThrough="0.59322" /MaxDrop="5.27268" /score="-5.47050177" /energy="-8.1" /TU="NA" /idTUdmin="U2880" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3590825..3590843) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3590836) /Source="Nicolas_upshifts" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" promotor_-35 complement(3590857..3590863) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3590872..3591372) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391549.2" /db_xref="EnsemblGenomes-Gn:BSU36680" /db_xref="EnsemblGenomes-Tr:CAB15685" /db_xref="GOA:P70963" /db_xref="SubtiList:BG12477" /db_xref="UniProtKB/Swiss-Prot:P70963" /translation="MHVRGNSMFGFNDMVKFLWSFLIVLPLVQIIHVSGHSFMAFIFG GKGSLDIGMGKTLLKIGPIRFRTIYFIDSFCRYGELKIDNRFSNALVYAGGCLFNLIT IFAINLLIIHSVLKPNVFFYQFVYFSTYYVFFALLPVRYSEKKSSDGLAIYKVLRYGE RYEIDK*" gene complement(3590872..3591372) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" promotor_-10 complement(3591408..3591427) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3591415) /Source="Nicolas_upshifts" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" promotor_-35 complement(3591441..3591447) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3591507..3592640) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9843420, 10629174, 12875849, 19332814, 19684115" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9843420, 10629174, 12875849, 19332814, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391550.1" /db_xref="EnsemblGenomes-Gn:BSU36690" /db_xref="EnsemblGenomes-Tr:CAB15686" /db_xref="GOA:P70962" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11965" /db_xref="UniProtKB/Swiss-Prot:P70962" /translation="MAAYEIPSSQVGVKINKWYKHILAFQVADAVKLKEEIDLDIEQM EEDQLLLLYYQLISYRHQIMLDYVKPDLHEESQLQYRELIKTLESNQDSISGLSEYYF HLFRGMYEFEQNNYISAISFYRKAEKMLAFVEDEIERAEFHFKVAEVFYIMKQTHFSM NHAVQALETYKAHDFYRVRRIQCHFVISGNYIDYRNYEKALEHLDDAYRLALLEGQPR LIGSALYNIGNCYDDKGELDQAAEYFEKALPVFEDYQLEQLPKALFSLTRVLFKKQDS EAAIRYYEKGIAIAQKRNDFFSLAKYKFLQALYVESVNLNMIQEVFDYMEEKGLYVYI EEFALDAASYFSHREQYKEAVYFYEKAVSMREMIQRNDCLYEV*" gene complement(3591507..3592640) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" downshifts complement(3591525) /Source="Nicolas_upshifts" /id="D1901" /incds=0 /nref=244 /ntot=265 /MaxReadThrough="2.8683" /MaxDrop="6.81344" /score="30.5146793" /energy="-8.1" /TU="NA" /idTUdmin="U2883" /TUdmin=0 /isTUend="TRUE" misc_feature complement(3592667..3592686) /Source="Nicolas_upshift_promotors" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3592674) /Source="Nicolas_upshifts" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" promotor_-10 complement(3592737..3592755) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3592753) /Source="Nicolas_upshifts" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" promotor_-35 complement(3592769..3592776) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3592832..3593857) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" /EC_number="4.1.99.22" /function="16.10: Respire" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170340, 7860592, 16632608, 19566093, 23286307, 25896388, 25941396, 26575208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP 3',8-cyclase" /protein_id="NP_391551.1" /db_xref="EnsemblGenomes-Gn:BSU36700" /db_xref="EnsemblGenomes-Tr:CAB15687" /db_xref="GOA:P39757" /db_xref="InterPro:IPR000385" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010505" /db_xref="InterPro:IPR013483" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034395" /db_xref="InterPro:IPR034481" /db_xref="SubtiList:BG10980" /db_xref="UniProtKB/Swiss-Prot:P39757" /translation="MITESRQMLDKRNRPLRDLRISVTDRCNFRCTYCMPAELFGPDY PFLKKEELLSFEELERLATLFVTRFGVEKIRLTGGEPLMRKDMPELIKKLARIPGIRD IAMTTNGSLLPVYAKRLKEAGLKRVTISLDSLEDERFKKINGRGVSVSKVLEGIEAAK QAGLGVKINMVVQKGVNEKDILPMARYFKEKGHILRFIEFMDVGNTNQWEKKDVMTKA EIIDLINKHMPVEPIAPNYIGEVASRFRYLDGSGEIGVISSVSDAFCGSCNRARLSAR GELFTCLFASSGFDLRAPVRQELSDDELSEMIGTVWKNRIDQYSVDRTLSKASGKKKV EMSYIGG*" gene complement(3592832..3593857) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" downshifts complement(3592845) /Source="Nicolas_upshifts" /id="D1902" /incds=0 /nref=23 /ntot=147 /MaxReadThrough="3.05546" /MaxDrop="3.66108" /score="13.625744" /energy="-10.8" /TU="NA" /idTUdmin="U2885" /TUdmin=0 /isTUend="TRUE" CDS complement(3593873..3594661) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" /function="16.11: Scavenge (Catabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2170340, 7860592, 19114526, 20011599, 22194618; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein sulfur transferase involved in molybdenum cofactor synthesis" /protein_id="NP_391552.1" /db_xref="EnsemblGenomes-Gn:BSU36710" /db_xref="EnsemblGenomes-Tr:CAB15688" /db_xref="GOA:P39756" /db_xref="InterPro:IPR003786" /db_xref="InterPro:IPR016193" /db_xref="SubtiList:BG10979" /db_xref="UniProtKB/Swiss-Prot:P39756" /translation="MNDKVTAVRDVWRYEQGEISKVEDRMVTEFPLTVILNGSEFVTL VCTPEHIEELVIGFLASEGVIRFQKEIKRFTIDESLGFVYVDLVHPETLDQKDYTKRV IGSCCGKGRHFYFQQDVKTAKTAVSQIKISPEACLALMKDMQQGSGTFQDTGGVHNAA LCDTEKLLLMRTDIGRHNALDKLYGHCLLNGMSVRDKLIVFSGRISSEVLLKAAKIGV SIVISKSAPTELAIQMAEELNITAIGFVRNGSFNVYTHPERIRE*" gene complement(3593873..3594661) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" promotor_-10 complement(3594687..3594706) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3594693) /Source="Nicolas_upshifts" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" S_feature complement(3594695..3594906) /Source="Nicolas_S_feature" /locus_tag="new_3774188_3774399_c" /HighExp="Etha, Sw, Salt, Heat, S8, Gly, S6, S7, BC, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16930300000000001" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1418" promotor_-35 complement(3594720..3594727) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3594907..3595068) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391553.1" /db_xref="EnsemblGenomes-Gn:BSU36720" /db_xref="EnsemblGenomes-Tr:CAB15689" /db_xref="GOA:P70966" /db_xref="SubtiList:BG12476" /db_xref="UniProtKB/Swiss-Prot:P70966" /translation="MKLFGMIFLIATVAFILLGVLLKLAAFFFVSILTLIAAIVLFTV LKKNQHNQT*" gene complement(3594907..3595068) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" promotor_-10 complement(3595081..3595099) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-10" upshifts complement(3595101) /Source="Nicolas_upshifts" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" promotor_-35 complement(3595113..3595119) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-35" CDS complement(3595162..3595836) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391554.1" /db_xref="EnsemblGenomes-Gn:BSU36730" /db_xref="EnsemblGenomes-Tr:CAB15690" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12475" /db_xref="UniProtKB/Swiss-Prot:P70961" /translation="MKKLLAAGIIGLLTVSIASPSFAAEKQADTNVAVLFDGSGSMVQ KTGGERKIDIAKKSVKSFAELLPKDTNLMLRVFGHAGNNKLSGKALSCSTTETIYGLH PYEGSLFDNSLSELKPTGWTPIAKALADTRKEFEAFDADGKNVVYLITDGEETCGGDP AAEIEKLRASNVDTIVNIIGFNFDVKGNEEMKQAAVAGGGEYISANSADEFEQAWEKE AQKFTE*" gene complement(3595162..3595836) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" downshifts complement(3595177) /Source="Nicolas_upshifts" /id="D1903" /incds=0 /nref=16 /ntot=88 /MaxReadThrough="0.76221" /MaxDrop="4.19611" /score="25.2461653" /energy="-9.6" /TU="NA" /idTUdmin="U2886" /TUdmin="-462" /isTUend="FALSE" CDS complement(3595889..3596029) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514009.1" /translation="MITQAVYAFWAEMAKNERHFKRFWTDRESSTKGSMSYIFLHFRI LA*" gene complement(3595889..3596029) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" CDS complement(3596160..3596843) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391555.1" /db_xref="EnsemblGenomes-Gn:BSU36740" /db_xref="EnsemblGenomes-Tr:CAB15691" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12474" /db_xref="UniProtKB/Swiss-Prot:P70960" /translation="MKKRFSLIMMTGLLFGLTSPAFAAEKTETEAKAPANVAVLLDAS GSMAKRIDGVSKFNSAKKEISKFASSLPEGTQVKMSVFGSEGNNKNSGKVQSCEAIRN VYGFQSFNEQSFLNSLNTIGPTGWTPIAKALNEAKSSFDQLDAKGEKVVYLLTDGEET CGGNPIKTAKELQKDNITVNVIGFDYKEGYKGQLNAIAKVGGGEYFPAYTQKDVEKIF TQQSLMLSK*" gene complement(3596160..3596843) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" promotor_-35 3597220..3597224 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3597229..3598260) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15752199, 16959571, 17376078, 27226615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15752199, 16959571, 17376078, 27226615; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="lytic transglycosylase; autolysin required for complete dissolution of the asymmetric septum (stage II sporulation)" /protein_id="NP_391556.1" /db_xref="EnsemblGenomes-Gn:BSU36750" /db_xref="EnsemblGenomes-Tr:CAB15692" /db_xref="GOA:P07372" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="InterPro:IPR014225" /db_xref="SubtiList:BG10766" /db_xref="UniProtKB/Swiss-Prot:P07372" /translation="MKQFAITLSVLCALILLVPTLLVIPFQHNKEAGASVESEKTAVS TKPASKGAETLKASPVSIPVYRTANQSVENIPLEEYVIGVVASEMPATFKPEALKAQA LAARTFIVRLMVSNSAVEAPKGSLVDDTQMFQVYKSKAELKKQWGTSYETKLKKITDA VASTQGKILTYNNQPIEASFFSTSNGYTENAEAYWTSAIPYLKSVKSPWDKKSPKYKA TKTFTAAEFQQKLGVKLDGSSAVGKITGETPGHQVATAVINGKTLKGRDIREKLGLNS ADFEWKRNGDTITVTTRGFGHGVGMSQYGANFMAKEGKTVDDIVKYYYQGTQISEADA FLNKYMAKK*" gene complement(3597229..3598260) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" promotor_-10 3597239..3597258 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3597245) /Source="Nicolas_upshifts" /id="D1904" /incds=0 /nref=56 /ntot=156 /MaxReadThrough="0.87893" /MaxDrop="6.31542" /score="12.1351765" /energy="-8.7" /TU="NA" /idTUdmin="U2888" /TUdmin=0 /isTUend="TRUE" upshifts 3597257 /Source="Nicolas_upshifts" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3598288..3598306) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3598301) /Source="Nicolas_upshifts" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" S_feature complement(3598303..3598420) /Source="Nicolas_S_feature" /locus_tag="new_3777796_3777913_c" /HighExp="S8, M40t90, M9-stat, B36, LBGtran, G180, H2O2, M0t90, BT, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigI, SigWXY, SigA" /TUshortPSig="0.947, 0.999, 1, 0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1419" promotor_-35 complement(3598322..3598327) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3598362..3598367 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3598379..3601039 /Source="Nicolas_S_feature" /locus_tag="new_3777872_3780532" /HighExp="S8, S6, S7, S4, S3, C30, S5, T5.0H, T3.30H, BT" /AntisenseName="murAA" /AntisenseCor="5.8371061376981899E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.971" /TUlongSig="NA" /TUlongPSig="NA" /label="S1420" upshifts 3598379 /Source="Nicolas_upshifts" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" promotor_-10 3598383..3598401 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3598456..3599766) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" /EC_number="2.5.1.7" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 14763982, 17714441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14763982, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391557.1" /db_xref="EnsemblGenomes-Gn:BSU36760" /db_xref="EnsemblGenomes-Tr:CAB15693" /db_xref="GOA:P70965" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG11955" /db_xref="UniProtKB/Swiss-Prot:P70965" /translation="MEKIIVRGGQKLNGTVKVEGAKNAVLPVIAASLLASEEKSVICD VPTLSDVYTINEVLRHLGADVHFENNEVTVNASYALQTEAPFEYVRKMRASVLVMGPL LARTGHARVALPGGCAIGSRPIDQHLKGFEAMGAEIKVGNGFIEAEVKGRLQGAKIYL DFPSVGATENLIMAAALAEGTTTLENVAKEPEIVDLANYINGMGGKIRGAGTGTIKIE GVEKLHGVKHHIIPDRIEAGTFMVAAAITEGNVLVKGAVPEHLTSLIAKMEEMGVTIK DEGEGLRVIGPKELKPIDIKTMPHPGFPTDMQSQMMALLLRASGTSMITETVFENRFM HAEEFRRMNGDIKIEGRSVIINGPVQLQGAEVAATDLRAGAALILAGLVAEGHTRVTE LKHLDRGYVDFHQKLAALGADIERVNDESASEQENKEVVSDLNA*" gene complement(3598456..3599766) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" downshifts complement(3598465) /Source="Nicolas_upshifts" /id="D1905" /incds=0 /nref=171 /ntot=256 /MaxReadThrough="5.3301" /MaxDrop="5.5423" /score="31.3825723" /energy="-11.8" /TU="U2890,U2891,U2892,U2894" /idTUdmin="U2890" /TUdmin="-98" /isTUend="FALSE" promotor_-10 complement(3599790..3599809) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3599797) /Source="Nicolas_upshifts" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" CDS complement(3599800..3600540) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391558.1" /db_xref="EnsemblGenomes-Gn:BSU36770" /db_xref="EnsemblGenomes-Tr:CAB15694" /db_xref="InterPro:IPR014794" /db_xref="InterPro:IPR036209" /db_xref="PDB:2FPN" /db_xref="SubtiList:BG12473" /db_xref="UniProtKB/Swiss-Prot:O32277" /translation="MKKKQVSHAIIISVMLSFVIAVFHTIHASELTPLAQMAEGMERQ DVSIDKWTLHAKQNLSLTEKEFYQKVQRLKQEYRQYDWVIAREDKMIKAIGTYTDKKN RTSFRLQLVTTLKKHNPTSYLLYEQMSLETPDSWNDTYEQFERETLGIFQEKVVIFTC LNGHLDDNMNIVLQKKANQLLNEFQARSVEHVVEPNFVSISAFTDEWEEYIMTSKHKM NLQIALRSAGMGGKHTVTVGTPIVTTEY*" gene complement(3599800..3600540) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" promotor_-35 complement(3599823..3599832) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3600171) /Source="Nicolas_upshifts" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" promotor_-10 complement(3600173..3600181) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3600195..3600203) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3600295..3600310) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3600303) /Source="Nicolas_upshifts" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" promotor_-35 complement(3600323..3600332) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3600541..3600668) /Source="Nicolas_S_feature" /locus_tag="new_3780034_3780161_c" /HighExp="UNK1, S2, Lbexp, MG 60, MG 15, M9-tran, M/G, G135, MG 5, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1421" CDS complement(3600669..3600899) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391559.1" /db_xref="EnsemblGenomes-Gn:BSU36780" /db_xref="EnsemblGenomes-Tr:CAB15695" /db_xref="GOA:O32278" /db_xref="InterPro:IPR009526" /db_xref="SubtiList:BG14163" /db_xref="UniProtKB/Swiss-Prot:O32278" /translation="MSVLGQQAAIGIVVHLIFIAVTWWALQAVNIDPLIKKGKVVQAR LLMILLTIAIGTAVANFFLDYLNYSQQLPYLF*" gene complement(3600669..3600899) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" S_feature complement(3600900..3601162) /Source="Nicolas_S_feature" /locus_tag="new_3780393_3780655_c" /HighExp="UNK1, S2, Lbexp, MG 5, M9-tran, M/G, MG 15, MG 60, GM 15, MG t5" /AntisenseName="ywmA" /AntisenseCor="-0.24099136307237601" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1422" misc_feature 3601035..3601054 /Source="Nicolas_upshift_promotors" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3601041 /Source="Nicolas_upshifts" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" CDS 3601069..3601542 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391560.1" /db_xref="EnsemblGenomes-Gn:BSU36790" /db_xref="EnsemblGenomes-Tr:CAB15696" /db_xref="SubtiList:BG12472" /db_xref="UniProtKB/Swiss-Prot:P70958" /translation="MNHSFFQPEKQYGEDLPIFDQEWEAIAFYYDYRQSQIEELNELC QFFNISLTYTRESLEELENLYFQSIQELLLADWNLPIEEFEKMISVYLIDCVIARHED AEWVVKPYPYKDGAYTLGFRRHRKSWHTMNACDGLYLRPKEDRPLLSLFDSLVRS*" gene 3601069..3601542 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" promotor_-10 complement(3601146..3601165) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-10" upshifts complement(3601162) /Source="Nicolas_upshifts" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" S_feature complement(3601164..3601547) /Source="Nicolas_S_feature" /locus_tag="new_3780657_3781040_c" /HighExp="G135, G180, G150, H2O2, Oxctl, Paraq, Cold, M9-stat, C30, S0" /AntisenseName="ywmA" /AntisenseCor="-1.9581968147303098E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1423" promotor_-35 complement(3601180..3601183) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-35" CDS complement(3601576..3601974) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" /EC_number="3.6.3.14" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8021203, 12837747, 15347741, 22720735, 23967352" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 12837747, 15347741, 22720735, 23967352; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit epsilon, F1 subunit)" /protein_id="NP_391561.1" /db_xref="EnsemblGenomes-Gn:BSU36800" /db_xref="EnsemblGenomes-Tr:CAB15697" /db_xref="GOA:P37812" /db_xref="InterPro:IPR001469" /db_xref="InterPro:IPR020546" /db_xref="InterPro:IPR020547" /db_xref="InterPro:IPR036771" /db_xref="InterPro:IPR036794" /db_xref="SubtiList:BG10822" /db_xref="UniProtKB/Swiss-Prot:P37812" /translation="MKTVKVNIVTPDGPVYDADIEMVSVRAESGDLGILPGHIPTVAP LKIGAVRLKKDGQTEMVAVSGGFVEVRPDHVTILAQAAETAEGIDKERAEAARQRAQE RLNSQSDDTDIRRAELALQRALNRLDVAGK*" gene complement(3601576..3601974) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" downshifts complement(3601592) /Source="Nicolas_upshifts" /id="D1906" /incds=0 /nref=283 /ntot=320 /MaxReadThrough="4.15968" /MaxDrop="7.84101" /score="22.7623678" /energy="-10.8" /TU="U2897,U2899" /idTUdmin="U2895" /TUdmin=9 /isTUend="TRUE" promotor_-10 complement(3601966..3601984) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3601975) /Source="Nicolas_upshifts" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" promotor_-35 complement(3601998..3602004) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3601998..3603419) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit beta, component F1)" /protein_id="NP_391562.1" /db_xref="EnsemblGenomes-Gn:BSU36810" /db_xref="EnsemblGenomes-Tr:CAB15698" /db_xref="GOA:P37809" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005722" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR024034" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10821" /db_xref="UniProtKB/Swiss-Prot:P37809" /translation="MKKGRVSQVLGPVVDVRFEDGHLPEIYNAIKISQPAASENEVGI DLTLEVALHLGDDTVRTIAMASTDGVQRGMEAVDTGAPISVPVGDVTLGRVFNVLGEN IDLNEPVPADAKKDPIHRQAPSFDQLSTEVEILETGIKVVDLLAPYIKGGKIGLFGGA GVGKTVLIQELINNIAQEHGGISVFAGVGERTREGNDLFYEMSDSGVINKTAMVFGQM NEPPGARMRVALTGLTMAEHFRDVQGQDVLFFIDNIFRFTQAGSEVSALLGRMPSAVG YQPTLATEMGQLQERITSTNVGSVTSIQAIYVPADDYTDPAPATTFAHLDATTNLERK LTEMGIYPAVDPLASTSRALAPEIVGEEHYAVAREVQSTLQRYKELQDIIAILGMDEL GEEDKLVVHRARRIQFFLSQNFHVAEQFTGQKGSYVPVKETVQGFKEILAGKYDHLPE DAFRLVGRIEEVVEKAKEMGVEV*" gene complement(3601998..3603419) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" CDS complement(3603445..3604308) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit gamma, component F1)" /protein_id="NP_391563.1" /db_xref="EnsemblGenomes-Gn:BSU36820" /db_xref="EnsemblGenomes-Tr:CAB15699" /db_xref="GOA:P37810" /db_xref="InterPro:IPR000131" /db_xref="InterPro:IPR023632" /db_xref="InterPro:IPR035968" /db_xref="SubtiList:BG10820" /db_xref="UniProtKB/Swiss-Prot:P37810" /translation="MASLRDIKSRITSTKKTSQITKAMQMVSAAKLNRAENNAKSFVP YMDKIQEVVSNVGRVSGNVKHPMLLSREVKKTAYLVITSDRGLAGAFNSSVLRSAYQA MQERHQSKDEYAVIAIGRVGRDFFKKREIPIISELTGLGDEVTFTEIKDLARQTIQMF IDGAFDELHLVYNHFVSAITQEVTEKKLLPLSDLGSGGGKRTASYEFEPSEEEVLEVL LPQYAESLIFGALLDSKASEHAARMTAMKNATDNAKELIDSLSLSYNRARQAAITQEI TEIVGGAAALE*" gene complement(3603445..3604308) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" S_feature complement(3604309..3604384) /Source="Nicolas_S_feature" /locus_tag="new_3783802_3783877_c" /HighExp="S0, S2, MG-0.2, MG-0.1, Mal, G150, BI, M0t45, G180, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1424" CDS complement(3604385..3605893) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit alpha, component F1)" /protein_id="NP_391564.1" /db_xref="EnsemblGenomes-Gn:BSU36830" /db_xref="EnsemblGenomes-Tr:CAB15700" /db_xref="GOA:P37808" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR000793" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005294" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033732" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10819" /db_xref="UniProtKB/Swiss-Prot:P37808" /translation="MSIKAEEISTLIKQQIQNYQSDIEVQDVGTVIQVGDGIARVHGL DNCMAGELVEFSNGVLGMAQNLEESNVGIVILGPFSEIREGDEVKRTGRIMEVPVGEE LIGRIVNPLGQPVDGLGPILTSKTRPIESPAPGVMDRKSVHEPLQTGIKAIDALIPIG RGQRELIIGDRQTGKTSVAIDAILNQKDQDMICVYVAIGQKESTVRGVVETLRKHGAL DYTIVVTASASQPAPLLYLAPYAGVTMAEEFMYNGKHVLVVYDDLSKQAAAYRELSLL LRRPPGREAFPGDVFYLHSRLLERAAKLSDAKGAGSITALPFVETQAGDISAYIPTNV ISITDGQIFLQSDLFFSGVRPAINAGLSVSRVGGSAQIKAMKKVSGTLRLDLASYREL EAFAQFGSDLDQATQAKLNRGARTVEVLKQDLNKPLPVEKQVAILYALTKGYLDDIPV ADIRRFEEEYYMYLDQNHKDLLDGIAKTGNLPADEDFKAAIEGFKRTFAPSN*" gene complement(3604385..3605893) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" CDS complement(3605910..3606455) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit delta, component F1)" /protein_id="NP_391565.1" /db_xref="EnsemblGenomes-Gn:BSU36840" /db_xref="EnsemblGenomes-Tr:CAB15701" /db_xref="GOA:P37811" /db_xref="InterPro:IPR000711" /db_xref="InterPro:IPR020781" /db_xref="InterPro:IPR026015" /db_xref="SubtiList:BG10818" /db_xref="UniProtKB/Swiss-Prot:P37811" /translation="MSGSAVSKRYASALFDIANESAQLNQVEEELIVVKQVFQNEKAL NDVLNHPKVPAAKKKELIQNAFGSLSQSVLNTIFLLIDRHRAAIVPELTDEFIKLANV ARQTEDAIVYSVKPLTDAEMLPLSQVFAKKAGVASLRIRNEVQTDLIGGIKVRIGNRI YDGSVSGKLQRIERQLAGENR*" gene complement(3605910..3606455) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" CDS complement(3606452..3606964) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit b, component F0)" /protein_id="NP_391566.1" /db_xref="EnsemblGenomes-Gn:BSU36850" /db_xref="EnsemblGenomes-Tr:CAB15702" /db_xref="GOA:P37814" /db_xref="InterPro:IPR002146" /db_xref="InterPro:IPR005864" /db_xref="InterPro:IPR028987" /db_xref="SubtiList:BG10817" /db_xref="UniProtKB/Swiss-Prot:P37814" /translation="MSQLPLELGLSFNGGDILFQLLAMLILLALLKKYALGPLLNIMK QREDHIAGEITSAEEKNKEAQQLIEEQRVLLKEARQESQTLIENAKKLGEKQKEEIIQ AARAESERLKEAARTEIVKEKEQAVSALREQVASLSVMIASKVIEKELDEQAQEKLIQ DYLKEVGESR*" gene complement(3606452..3606964) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" S_feature complement(3606965..3607126) /Source="Nicolas_S_feature" /locus_tag="new_3786458_3786619_c" /HighExp="S2, Lbstat, Mal, M40t90, M0t90, G150, MG-0.1, G135, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1425" CDS complement(3607127..3607339) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit c, component F0)" /protein_id="NP_391567.1" /db_xref="EnsemblGenomes-Gn:BSU36860" /db_xref="EnsemblGenomes-Tr:CAB15703" /db_xref="GOA:P37815" /db_xref="InterPro:IPR000454" /db_xref="InterPro:IPR002379" /db_xref="InterPro:IPR005953" /db_xref="InterPro:IPR020537" /db_xref="InterPro:IPR035921" /db_xref="SubtiList:BG10816" /db_xref="UniProtKB/Swiss-Prot:P37815" /translation="MNLIAAAIAIGLGALGAGIGNGLIVSRTVEGIARQPEAGKELRT LMFMGIALVEALPIIAVVIAFLAFFG*" gene complement(3607127..3607339) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" CDS complement(3607385..3608119) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit a, component F0)" /protein_id="NP_391568.1" /db_xref="EnsemblGenomes-Gn:BSU36870" /db_xref="EnsemblGenomes-Tr:CAB15704" /db_xref="GOA:P37813" /db_xref="InterPro:IPR000568" /db_xref="InterPro:IPR023011" /db_xref="InterPro:IPR035908" /db_xref="SubtiList:BG10815" /db_xref="UniProtKB/Swiss-Prot:P37813" /translation="MNHGYRTIEFLGLTFNLTNILMITVASVIVLLIAILTTRTLSIR PGKAQNFMEWIVDFVRNIIGSTMDLKTGANFLALGVTLLMYIFVSNMLGLPFSITIGH ELWWKSPTADPAITLTLAVMVVALTHYYGVKMKGLKEYSKDYLRPVPFMLPMKIIEEF ANTLTLGLRLYGNIFAGEILLGLLAGLATSHYSQSVALGLVGTIGAILPMLAWQAFSL FIGAIQAFIFTMLTMVYMSHKISHDH*" gene complement(3607385..3608119) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" promotor_no_box 3607933..3608033 /Source="Nicolas_upshift_promotors" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3607993 /Source="Nicolas_upshifts" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3608127..3608510) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" /function="16.1: Circulate" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12917488, 15849754, 16850406, 23123906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12917488, 15849754, 16850406, 23123906; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit i)" /protein_id="NP_391569.1" /db_xref="EnsemblGenomes-Gn:BSU36880" /db_xref="EnsemblGenomes-Tr:CAB15705" /db_xref="GOA:P37816" /db_xref="InterPro:IPR005598" /db_xref="SubtiList:BG10814" /db_xref="UniProtKB/Swiss-Prot:P37816" /translation="MDDPKLTFSRQRKYLLFILAVYVLGYGLTAYKTVFLGLILGTVF SLFNFLLLVRRMNAFDRAVEKGKSIRSLGSAARWCNAILAVAVAYKNPEYFHMASTVI GLMTIYPVIMIDSFIQLKRSSMEER*" gene complement(3608127..3608510) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" misc_feature complement(3608199..3608217) /Source="Nicolas_upshift_promotors" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3608201) /Source="Nicolas_upshifts" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" S_feature complement(3608511..3608781) /Source="Nicolas_S_feature" /locus_tag="new_3788004_3788274_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, UNK1, B60, G135, G180, G150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.96" /label="S1426" promotor_-35 3608743..3608752 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3608752 /Source="Nicolas_upshifts" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3608757..3608776) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" promotor_-10 3608766..3608785 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3608781) /Source="Nicolas_upshifts" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" S_feature complement(3608783..3608904) /Source="Nicolas_S_feature" /locus_tag="new_3788276_3788397_c" /HighExp="Etha, G180, H2O2, G135, Oxctl, G150, LBGexp, dia15, B36, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.96" /label="S1427" promotor_-35 complement(3608789..3608796) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3608933..3609562) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" /EC_number="2.4.2.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7798145, 15689504, 15716449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 15689504, 15716449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil phosphoribosyltransferase" /protein_id="NP_391570.1" /db_xref="EnsemblGenomes-Gn:BSU36890" /db_xref="EnsemblGenomes-Tr:CAB15706" /db_xref="GOA:P39149" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005765" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR034332" /db_xref="SubtiList:BG10945" /db_xref="UniProtKB/Swiss-Prot:P39149" /translation="MGKVYVFDHPLIQHKLTYIRNENTGTKDFRELVDEVATLMAFEI TRDLPLEEVDINTPVQAAKSKVISGKKLGVVPILRAGLGMVDGILKLIPAAKVGHVGL YRDPETLKPVEYYVKLPSDVEEREFIVVDPMLATGGSAVEAIHSLKKRGAKNIRFMCL VAAPEGVEELQKHHSDVDIYIAALDEKLNEKGYIVPGLGDAGDRMFGTK*" gene complement(3608933..3609562) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" downshifts complement(3608949) /Source="Nicolas_upshifts" /id="D1907" /incds=0 /nref=180 /ntot=252 /MaxReadThrough="5.83241" /MaxDrop="5.91252" /score="1.39547358" /energy="-7.3" /TU="U2900,U2901" /idTUdmin="U2900" /TUdmin="-154" /isTUend="FALSE" promotor_-10 complement(3609606..3609625) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" upshifts complement(3609629) /Source="Nicolas_upshifts" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" promotor_-35 complement(3609640..3609647) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3609697..3610944) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" /EC_number="2.1.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine hydroxymethyltransferase" /protein_id="NP_391571.1" /db_xref="EnsemblGenomes-Gn:BSU36900" /db_xref="EnsemblGenomes-Tr:CAB15707" /db_xref="GOA:P39148" /db_xref="InterPro:IPR001085" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR019798" /db_xref="SubtiList:BG10944" /db_xref="UniProtKB/Swiss-Prot:P39148" /translation="MKHLPAQDEQVFNAIKNERERQQTKIELIASENFVSEAVMEAQG SVLTNKYAEGYPGKRYYGGCEHVDVVEDIARDRAKEIFGAEHVNVQPHSGAQANMAVY FTILEQGDTVLGMNLSHGGHLTHGSPVNFSGVQYNFVEYGVDKETQYIDYDDVREKAL AHKPKLIVAGASAYPRTIDFKKFREIADEVGAYFMVDMAHIAGLVAAGLHPNPVPYAD FVTTTTHKTLRGPRGGMILCREEFGKKIDKSIFPGIQGGPLMHVIAAKAVSFGEVLQD DFKTYAQNVISNAKRLAEALTKEGIQLVSGGTDNHLILVDLRSLGLTGKVAEHVLDEI GITSNKNAIPYDPEKPFVTSGIRLGTAAVTSRGFDGDALEEVGAIIALALKNHEDEGK LEEARQRVAALTDKFPLYKELDY*" gene complement(3609697..3610944) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" downshifts complement(3609720) /Source="Nicolas_upshifts" /id="D1908" /incds=0 /nref=183 /ntot=229 /MaxReadThrough="5.99283" /MaxDrop="6.62881" /score="22.1245386" /energy="-15.8" /TU="U2901" /idTUdmin="U2902" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(3610986..3611005) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3611003) /Source="Nicolas_upshifts" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" S_feature complement(3611005..3611089) /Source="Nicolas_S_feature" /locus_tag="new_3790498_3790582_c" /HighExp="dia5, C90, dia15, Diami, Lbtran, LPhT, M40t45, H2O2, BI, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1428" promotor_-35 complement(3611020..3611025) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3611134) /Source="Nicolas_upshifts" /id="D1909" /incds=0 /nref=3 /ntot=12 /MaxReadThrough="7.23859" /MaxDrop="5.0386" /score="-3.86767322" /energy="-4.3" /TU="U2902,U2903" /idTUdmin="U2904" /TUdmin=1137 /isTUend="FALSE" CDS complement(3611151..3611693) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210, 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391572.1" /db_xref="EnsemblGenomes-Gn:BSU36910" /db_xref="EnsemblGenomes-Tr:CAB15708" /db_xref="InterPro:IPR006340" /db_xref="InterPro:IPR028345" /db_xref="SubtiList:BG10943" /db_xref="UniProtKB/Swiss-Prot:P39157" /translation="MNELKQTWKTMLSEFQDQAELKQDQLFVLGCSTSEVAGSRIGTS GSVDIAESIYSGLAELREKTGIHLAFQCCEHLNRALVVEAETAKLFRLPTVSAVPVPK AGGAMASYAFKQMKSPVLVETIQADAGIDIGDTFIGMHLKPVAVPVRVSQNSLGSAHV TLARTRPKLIGGVRAVYECE*" gene complement(3611151..3611693) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" CDS complement(3611706..3612155) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" /EC_number="5.3.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15755726, 15995210, 18640127, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 15995210, 18640127, 19446032; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose 5-phosphate epimerase (promiscuous)" /protein_id="NP_391573.1" /db_xref="EnsemblGenomes-Gn:BSU36920" /db_xref="EnsemblGenomes-Tr:CAB15709" /db_xref="GOA:P39156" /db_xref="InterPro:IPR003500" /db_xref="InterPro:IPR004785" /db_xref="InterPro:IPR036569" /db_xref="SubtiList:BG10942" /db_xref="UniProtKB/Swiss-Prot:P39156" /translation="MKVAIASDHGGVHIRNEIKELMDELQIEYIDMGCDCGSGSVDYP DYAFPVAEKVVSGEVDRGILICGTGIGMSISANKVKGIRCALAHDTFSAKATREHNDT NILAMGERVIGPGLAREIAKIWLTTEFTGGRHQTRIGKISDYEEKNL*" gene complement(3611706..3612155) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" S_feature complement(3612156..3612255) /Source="Nicolas_S_feature" /locus_tag="new_3791649_3791748_c" /HighExp="Diami, dia5, C90, dia15, LPhT, M40t45, LBGtran, Lbtran, T-0.40H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.68276199999999998" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1429" promotor_-10 complement(3612247..3612266) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-10" upshifts complement(3612255) /Source="Nicolas_upshifts" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" promotor_-35 complement(3612280..3612287) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-35" CDS complement(3612312..3612764) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" /EC_number="3.9.1.2" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210, 22517742, 24825175, 25610436, 27524296" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210, 22517742, 24825175, 25610436, 27524296; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-arginine(tyrosine moonlighting) phosphatase (oxidative stress)" /protein_id="NP_391574.1" /db_xref="EnsemblGenomes-Gn:BSU36930" /db_xref="EnsemblGenomes-Tr:CAB15710" /db_xref="GOA:P39155" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:1ZGG" /db_xref="PDB:4ETI" /db_xref="PDB:4ETN" /db_xref="PDB:4KK3" /db_xref="PDB:4KK4" /db_xref="SubtiList:BG10941" /db_xref="UniProtKB/Swiss-Prot:P39155" /translation="MDIIFVCTGNTCRSPMAEALFKSIAEREGLNVNVRSAGVFASPN GKATPHAVEALFEKHIALNHVSSPLTEELMESADLVLAMTHQHKQIIASQFGRYRDKV FTLKEYVTGSHGDVLDPFGGSIDIYKQTRDELEELLRQLAKQLKKDRR*" gene complement(3612312..3612764) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" promotor_-10 complement(3612781..3612800) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-10" upshifts complement(3612799) /Source="Nicolas_upshifts" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" promotor_-35 complement(3612815..3612818) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-35" CDS complement(3612840..3613397) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 25774656, 25794618, 26076491; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="manganese efflux pump" /protein_id="NP_391575.1" /db_xref="EnsemblGenomes-Gn:BSU36940" /db_xref="EnsemblGenomes-Tr:CAB15711" /db_xref="GOA:P39154" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR022929" /db_xref="SubtiList:BG10940" /db_xref="UniProtKB/Swiss-Prot:P39154" /translation="MSDLFIGELITLSIMAFALGMDAFSVGLGMGMVKLRKKQIFYIG FIIGLFHVIMPLAGMAAGNMLSGLLGVLAVYIGGALLFVLGVQMLMASFKQSEERFMS PAGPGLLLFAIGVSLDSFSVGLSLGIYGSHPLLTITLFGLFSMMLTWLGLLVGKQVQS WLGTYSEALGGIILIVFGLKLLLPI*" gene complement(3612840..3613397) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" promotor_-10 complement(3613424..3613442) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-10" upshifts complement(3613437) /Source="Nicolas_upshifts" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" promotor_-35 complement(3613458..3613463) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-35" CDS complement(3613476..3614516) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; threonine-dependent ADP-forming ATPase" /protein_id="NP_391576.1" /db_xref="EnsemblGenomes-Gn:BSU36950" /db_xref="EnsemblGenomes-Tr:CAB15712" /db_xref="GOA:P39153" /db_xref="InterPro:IPR005145" /db_xref="InterPro:IPR006070" /db_xref="InterPro:IPR010923" /db_xref="InterPro:IPR017945" /db_xref="SubtiList:BG10939" /db_xref="UniProtKB/Swiss-Prot:P39153" /translation="MKTKRWFVDVTDELSTNDPQIAQAAALLRENEVVAFPTETVYGL GANAKNTDAVKKIYEAKGRPSDNPLIVHIADISQLEDLTGPAPEKAKTLMKRFWPGAL TLILPCKPDALSPRVTAGLETVAIRMPDHPLALALIRESGLPIAAPSANLSGKPSPTK AEHVAHDLDGRIAGIVDGGPTGIGVESTVLSCADDIPVLLRPGGITKEQIEAVIGPIH VDKGLSDQNEKPISPGMKYTHYAPTAPLAICEGSPERIQHLIQEYQQGGRRVGVLTTE EKAGVYSADYVKSCGRRAQLETVAAGLYDALRSFDENKVDFIIAESFPDTGVGLAIMN RLMKAAGGRVIR*" gene complement(3613476..3614516) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" downshifts complement(3613481) /Source="Nicolas_upshifts" /id="D1910" /incds=0 /nref=4 /ntot=166 /MaxReadThrough="2.08557" /MaxDrop="2.98653" /score="-6.24994287" /energy="-9.8" /TU="NA" /idTUdmin="U2905" /TUdmin=0 /isTUend="TRUE" S_feature complement(3614517..3614581) /Source="Nicolas_S_feature" /locus_tag="new_3794010_3794074_c" /HighExp="dia15, Diami, C90, LBGstat, Heat, LBGtran, dia5, LBGexp, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1430" promotor_-10 complement(3614571..3614590) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3614581) /Source="Nicolas_upshifts" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" S_feature complement(3614583..3614672) /Source="Nicolas_S_feature" /locus_tag="new_3794076_3794165_c" /HighExp="S3, M9-stat, Etha, LoTm, T5.0H, S7, S8, S4, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1431" promotor_-35 complement(3614606..3614610) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3614673..3615116) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391577.1" /db_xref="EnsemblGenomes-Gn:BSU36960" /db_xref="EnsemblGenomes-Tr:CAB15713" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10938" /db_xref="UniProtKB/Swiss-Prot:P39152" /translation="MFYQLRVAREKDGDVLEAFLKQAKTSYEGVKEGFTQFLMLEDSE KNIAGCLGIEKISCDQGLLRSLVISDKLHQGHIVTLFQSMEVLCEKHQIKTVYLVANQ HSSADFLTAMGFERAESVPEELFSSDHFCESRQTEGAVLMKKASG*" gene complement(3614673..3615116) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" CDS complement(3615183..3615857) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15044948, 16824103, 18378688, 20802044, 22111992" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15044948, 16824103, 18378688, 20802044, 22111992; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator signal of pro-sigma(E) spoIIGA endopeptidase (stage II sporulation)" /protein_id="NP_391578.1" /db_xref="EnsemblGenomes-Gn:BSU36970" /db_xref="EnsemblGenomes-Tr:CAB15714" /db_xref="GOA:P39151" /db_xref="InterPro:IPR014202" /db_xref="SubtiList:BG10937" /db_xref="UniProtKB/Swiss-Prot:P39151" /translation="MKKTVIICIYIFLLLSGALVGLAKEETAQKSENQPVVIPDQAIR LRILANSDSDQDQQLKRHIRDAVNKEITTWVKDITSIEEARRVIRSKLPEIKAIAKET MEKEGANQSISVDFDKISFPTKLYGNMVYPAGEYEAILITLGNGDGANWWCVLFPPLC FLDFSNGEAVKEQEDKEASKKQTEKVLEDVTAKAEKAKKEENEEKEDGTEVKFFLVEW ISDLFS*" gene complement(3615183..3615857) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" promotor_-10 complement(3615619..3615637) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3615626) /Source="Nicolas_upshifts" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" promotor_-35 complement(3615652..3615658) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3615889..3615906) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3615890) /Source="Nicolas_upshifts" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" promotor_-35 complement(3615922..3615927) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3615963 /Source="Nicolas_upshifts" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" misc_feature 3615967..3615986 /Source="Nicolas_upshift_promotors" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3615998..3616360 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391579.1" /db_xref="EnsemblGenomes-Gn:BSU36980" /db_xref="EnsemblGenomes-Tr:CAB15715" /db_xref="GOA:P39150" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG10936" /db_xref="UniProtKB/Swiss-Prot:P39150" /translation="MKYNYTVLLSAFTMSVLYSVIYIHSFIIAALITMAFYFLFPYLI FALPLQIMMNKKPKRFSPLYLLYYLAAAFIANAIIFGMLQPSGQSLFQNTAFYLFAVL TALIYWIWDSVLLQKKEA*" gene 3615998..3616360 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" downshifts complement(3616373) /Source="Nicolas_upshifts" /id="D1911" /incds=0 /nref=27 /ntot=242 /MaxReadThrough="2.64328" /MaxDrop="5.72616" /score="26.8558862" /energy="-11.3" /TU="U2910" /idTUdmin="U2909" /TUdmin=12 /isTUend="TRUE" CDS complement(3616377..3616664) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391580.1" /db_xref="EnsemblGenomes-Gn:BSU36990" /db_xref="EnsemblGenomes-Tr:CAB15716" /db_xref="GOA:P45874" /db_xref="InterPro:IPR035167" /db_xref="SubtiList:BG11317" /db_xref="UniProtKB/Swiss-Prot:P45874" /translation="MKKALTAGILLIAIESMIGTIFPQALSYEAIFGVASLVLVGLAI ITSGLAVSGSDQRANYHSETKEGRTSRMKMAAAFFVAAIPSILCYLLTILF*" gene complement(3616377..3616664) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" S_feature complement(3616665..3616723) /Source="Nicolas_S_feature" /locus_tag="new_3796158_3796216_c" /HighExp="S6, S8, S7, BT, G135, G180, Paraq, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1432" promotor_-10 complement(3616721..3616740) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3616724..3617590) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" /EC_number="2.1.1.297" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 16364916, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine methylase of release factor 1 (and perhaps others) at a GGQ site" /protein_id="NP_391581.1" /db_xref="EnsemblGenomes-Gn:BSU37000" /db_xref="EnsemblGenomes-Tr:CAB15717" /db_xref="GOA:P45873" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004556" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR019874" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11316" /db_xref="UniProtKB/Swiss-Prot:P45873" /translation="MKTIFEALKWASSYLTEAGREENAAELLLLYDTGMERSKLLASL QEPIGEDELYRFKRHVEMHKEGVPVQYIIGKEFFYGREFMVNDDVLIPRPETEEVVFH LLEKYRSVFSEDGKLEVVDVGTGSGAIAVTLALENQSFSVSAVDISKEALQVASANAE KLGANVRFYQGDLLEPFIKAGKKADIIVSNPPYISEEEMADLSEIVRFHEPLHALTDG GDGLKFYKRFMEDIPLVMKDKVFVVFEIGWKQGAAVKDLILKAFKGAEVEVLKDINGK DRTICALIHKNK*" gene complement(3616724..3617590) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" upshifts complement(3616737) /Source="Nicolas_upshifts" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" promotor_-35 complement(3616753..3616762) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3617592..3618662) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" /experiment="publication(s) with functional evidences, PMID:2186375, 1408743, 10446248, 12237459, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2186375, 1408743, 10446248, 12237459, 12682299; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 1" /protein_id="NP_391582.1" /db_xref="EnsemblGenomes-Gn:BSU37010" /db_xref="EnsemblGenomes-Tr:CAB15718" /db_xref="GOA:P45872" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004373" /db_xref="InterPro:IPR005139" /db_xref="SubtiList:BG11244" /db_xref="UniProtKB/Swiss-Prot:P45872" /translation="MLDRLKSIEERYEKLNELLSDPEVVNDPKKLREYSKEQSDIQET VDVYRQYRDASEQLADAKAMLEEKLDAEMRDMVKEEISELQKETETLSERLKVLLIPK DPNDDKNVIMEIRGAAGGEEAALFAGNLYRMYSRYAELQGWKTEVMEANVTGTGGYKE IIFMITGSGAYSKLKYENGAHRVQRVPETESGGRIHTSTATVACLPEAEEVEVDIHEK DIRVDTFASSGPGGQSVNTTMSAVRLTHLPTGVVVSCQDEKSQIKNKEKAMKVLRARI YDKFQQEAQAEYDQTRKSAVGSGDRSERIRTYNFPQNRVTDHRIGLTIQKLDQILEGK LDEVVEALIVEDQASKLQQSEG*" gene complement(3617592..3618662) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" downshifts complement(3617595) /Source="Nicolas_upshifts" /id="D1912" /incds=0 /nref=23 /ntot=212 /MaxReadThrough="5.17118" /MaxDrop="3.44681" /score="-9.55295942" /energy="-10.5" /TU="U2910" /idTUdmin="U2912" /TUdmin=1122 /isTUend="FALSE" downshifts 3618663 /Source="Nicolas_upshifts" /id="D1913" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.13519" /MaxDrop="4.28706" /score="36.3991981" /energy="-10.4" /TU="NA" /idTUdmin="U2911" /TUdmin="-990" /isTUend="FALSE" promotor_-10 complement(3618690..3618709) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3618714) /Source="Nicolas_upshifts" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" S_feature complement(3618716..3618827) /Source="Nicolas_S_feature" /locus_tag="new_3798209_3798320_c" /HighExp="S6, S8, S7, BT, S5, Etha, B36, C30, S4, GM 25" /AntisenseName="ywkD" /AntisenseCor="-0.43140174721346802" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.927" /TUlongSig="NA" /TUlongPSig="NA" /label="S1433" promotor_-35 complement(3618723..3618729) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3618759..3618778 /Source="Nicolas_upshift_promotors" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3618773 /Source="Nicolas_upshifts" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" CDS 3618788..3619174 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391583.1" /db_xref="EnsemblGenomes-Gn:BSU37020" /db_xref="EnsemblGenomes-Tr:CAB15719" /db_xref="GOA:P45871" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11315" /db_xref="UniProtKB/Swiss-Prot:P45871" /translation="MLLKSIHHIAIICSDYEKSKAFYVHKLGFQVIQETYREERGSYK LDLSLNGSYVIELFSFPDPPERQTRPEAAGLRHLAFTVGSLDKAVQELHEKGIETEPI RTDPLTGKRFTFFFDPDQLPLELYEQ*" gene 3618788..3619174 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" promotor_-10 complement(3618809..3618827) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-10" upshifts complement(3618827) /Source="Nicolas_upshifts" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" promotor_-35 complement(3618841..3618848) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-35" promotor_-35 3619242..3619250 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3619261..3619279 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3619262 /Source="Nicolas_upshifts" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" CDS 3619296..3619850 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15780934, 17139259, 19478798, 22720735, 27059541, 27085804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15780934, 17139259, 19478798, 22720735, 27059541, 27085804; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome-pole-anchoring protein RacA" /protein_id="NP_391584.1" /db_xref="EnsemblGenomes-Gn:BSU37030" /db_xref="EnsemblGenomes-Tr:CAB15720" /db_xref="GOA:P45870" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR023522" /db_xref="PDB:5I41" /db_xref="PDB:5I44" /db_xref="SubtiList:BG11314" /db_xref="UniProtKB/Swiss-Prot:P45870" /translation="MNTNMVASELGVSAKTVQRWVKQLNLPAERNELGHYSFTAEDVK VLKSVQKQISEGTAIQDIHLPKSAKKRTGFLVQKTSSDTERRIEQLEQKLDTLLQQRQ DESELMARMSELERQLKQKADEGVSYQLLQHRREIDDILADLQSLTSQMKEFTAHSIP ETAAASEKTKTRKKPLLSLFKFQT*" gene 3619296..3619850 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" misc_feature 3619780..3619784 /Source="Nicolas_upshift_promotors" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3619785 /Source="Nicolas_upshifts" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 3619829 /Source="Nicolas_upshifts" /id="D1914" /incds=0 /nref=213 /ntot=274 /MaxReadThrough="0.82868" /MaxDrop="8.28021" /score="36.3991981" /energy="-10.4" /TU="U2913" /idTUdmin="U2914" /TUdmin=0 /isTUend="TRUE" CDS complement(3619884..3620843) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12949160, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391585.1" /db_xref="EnsemblGenomes-Gn:BSU37040" /db_xref="EnsemblGenomes-Tr:CAB15721" /db_xref="GOA:P45869" /db_xref="InterPro:IPR004776" /db_xref="InterPro:IPR014024" /db_xref="SubtiList:BG11313" /db_xref="UniProtKB/Swiss-Prot:P45869" /translation="MSILDILILLAPIFFVIVLGWFAGHFGSYDAKSAKGVSTLVTKY ALPAHFIAGILTTSRSEFLSQVPLMISLIIGIVGFYIIILLVCRFIFKYDLTNSSVFS LNSAQPTFAFMGIPVLGSLFGANEVAIPIAVTGIVVNAILDPLAIIIATVGESSKKNE ESGDSFWKMTGKSILHGLCEPLAAAPLISMILVLVFNFTLPELGVKMLDQLGSTTSGV ALFAVGVTVGIRKIKLSMPAIGIALLKVAVQPALMFLIALAIGLPADQTTKAILLVAF PGSAVAAMIATRFEKQEEETATAFVVSAILSLISLPIIIALTA*" gene complement(3619884..3620843) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" downshifts complement(3619906) /Source="Nicolas_upshifts" /id="D1915" /incds=0 /nref=36 /ntot=74 /MaxReadThrough="2.86006" /MaxDrop="4.78642" /score="20.048754" /energy="-10.4" /TU="U2916" /idTUdmin="U2917" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(3620881..3620899) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3620895) /Source="Nicolas_upshifts" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" promotor_-35 complement(3620914..3620920) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3620925..3622673) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12949160, 16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949160, 16788182, 20933603, 22740702, 23136871, 24325460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_391586.1" /db_xref="EnsemblGenomes-Gn:BSU37050" /db_xref="EnsemblGenomes-Tr:CAB15722" /db_xref="GOA:P45868" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11312" /db_xref="UniProtKB/Swiss-Prot:P45868" /translation="MGYYLTWLTISRKKEICLNNIKKTKEGHLETTLRGKEVLSIPTL NKGVAFSLEERQELGLEGLLPPTVLSLDQQAQRAYEQFQAQPDRLRQNVYLSDLANRN EVLFYKLLKNHLREMLPVVYTPTVGEAIQEYSHEYRRPQGIYLSIDNIDGIEKAFENL HATAGDIDLIVATDSESILGIGDWGVGGINIAIGKLAVYTAAAGIDPSRVIPVVLDVG TNNEKLLNDPLYIGNKHERVQGERYEAFIDAYVKAALKFFPKALLHWEDLGNKNARNI MKKYNHEILTFNDDIQGTGAITLAGVLAAMKKTGASIKDQRVVIFGAGSAGIGIADQI RDTMVLAGLSEEEANKRFYTLDYRGLLTEDIEGILDFQKPYLRNADEVKDWKRDEKGQ IPFDEVVRQAKPTILIGTSGVSGAFTEEIVKEMASHVDRPVIMPMSNPTHLAEAVPED LFKWTDGKVLIATGSPFDNVEYNGVSYEIGQSNNAFAFPGLGLGSIVAEARIITPAMF AATADAIAEMVDLETPGAGLLPSIDKLQEVSIQVAIAVAEAAIKDGVANRQPEDVKQA VLDAMWTPEYKKVIAK*" gene complement(3620925..3622673) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" promotor_-10 complement(3621399..3621417) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3621407) /Source="Nicolas_upshifts" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" promotor_-35 complement(3621432..3621438) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3622674..3622764) /Source="Nicolas_S_feature" /locus_tag="new_3802167_3802257_c" /HighExp="GM 25, GM 15, GM 60, GM 90, GM 120, MG-0.2, MG 15, GM 45, MG-0.1, GM 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1434" promotor_-10 complement(3622748..3622767) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3622764) /Source="Nicolas_upshifts" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" promotor_-35 complement(3622781..3622788) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3622907) /Source="Nicolas_upshifts" /id="D1916" /incds=0 /nref=11 /ntot=126 /MaxReadThrough="2.81368" /MaxDrop="3.39095" /score="20.3711149" /energy="-7.5" /TU="NA" /idTUdmin="U2918" /TUdmin="-10" /isTUend="TRUE" CDS complement(3622912..3623499) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" /EC_number="2.7.1.21" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2423635, 17132103; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidine kinase" /protein_id="NP_391587.1" /db_xref="EnsemblGenomes-Gn:BSU37060" /db_xref="EnsemblGenomes-Tr:CAB15723" /db_xref="GOA:Q03221" /db_xref="InterPro:IPR001267" /db_xref="InterPro:IPR020633" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10419" /db_xref="UniProtKB/Swiss-Prot:Q03221" /translation="MYIMKQSGWLELICGSMFSGKSEELIRRVKRATYAKQEVRVFKP VIDNRYSEAAVVSHNGTSMTSYAISSAADIWDHISESTDVVAVDEVQFFDQEIVEVLS SLADKGYRVIAAGLDMDFRGEPFGVVPNIMAIAESVTKLQAVCSVCGSPASRTQRLID GKPASYDDPVILVGAAESYEARCRHHHEVPGKSKK*" gene complement(3622912..3623499) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" CDS complement(3623588..3623788) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_391588.1" /db_xref="EnsemblGenomes-Gn:BSU37070" /db_xref="EnsemblGenomes-Tr:CAB15724" /db_xref="GOA:Q03223" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027491" /db_xref="InterPro:IPR034704" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10417" /db_xref="UniProtKB/Swiss-Prot:Q03223" /translation="MKAGIHPNFKKATVKCACGNEFETGSVKEEVRVEICSECHPFYT GRQKFASADGRVDRFNKKYGLK*" gene complement(3623588..3623788) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" downshifts complement(3623601) /Source="Nicolas_upshifts" /id="D1917" /incds=0 /nref=268 /ntot=279 /MaxReadThrough="5.35148" /MaxDrop="6.82076" /score="15.63162" /energy="-10.3" /TU="U2918,U2919" /idTUdmin="U2921" /TUdmin=0 /isTUend="TRUE" S_feature complement(3623789..3623866) /Source="Nicolas_S_feature" /locus_tag="new_3803282_3803359_c" /HighExp="HPh, LPh, LPhT, GM 45, Paraq, MG 45, MG 60, aero, LBGexp, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1435" promotor_-10 complement(3623862..3623881) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3623866) /Source="Nicolas_upshifts" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" promotor_-35 complement(3623895..3623902) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3623907..3625190) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10027981, 16014871, 18852477, 28520932, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10027981, 16014871, 18852477, 28520932, 28723971; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcriptional terminator Rho" /protein_id="NP_391589.2" /db_xref="EnsemblGenomes-Gn:BSU37080" /db_xref="EnsemblGenomes-Tr:CAB15725" /db_xref="GOA:Q03222" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004665" /db_xref="InterPro:IPR011112" /db_xref="InterPro:IPR011113" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036269" /db_xref="SubtiList:BG10416" /db_xref="UniProtKB/Swiss-Prot:Q03222" /translation="MKDVSISSLENMKLKELYELARHYKISYYSKLTKKELIFAILKA NAEQEDLLFMEGVLEIIQSEGFGFLRPINYSPSSEDIYISASQIRRFDLRNGDKVSGK VRPPKENERYYGLLHVEAVNGDDPESAKERVHFPALTPLYPDRQMVLETKPNFLSTRI MDMMAPVGFGQRGLIVAPPKAGKTMLLKEIANSITANQPEAELIVLLIDERPEEVTDI ERSVAGDVVSSTFDEVPENHIKVAELVLERAMRLVEHKKDVIILMDSITRLARAYNLV IPPSGRTLSGGIDPAAFHRPKRFFGAARNIEEGGSLTILATALVDTGSRMDDVIYEEF KGTGNMELHLDRSLAERRIFPAIDIRRSGTRKEELLVPKEHLDRLWSIRKTMSDSPDF AEKFMRKMKKTKTNQEFFDILNQEWKQANLSSARR*" gene complement(3623907..3625190) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" S_feature complement(3625191..3625493) /Source="Nicolas_S_feature" /locus_tag="new_3804684_3804986_c" /HighExp="H2O2, Cold, G135, HPh, G180, G150, LBGstat, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1436" CDS complement(3625221..3625382) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 20525796" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514010.1" /db_xref="EnsemblGenomes-Gn:BSU37089" /db_xref="EnsemblGenomes-Tr:CCQ48606" /db_xref="UniProtKB/TrEMBL:L8EA05" /translation="MFLSSLPSKLIKTILLTKAPIMGGSVTDRSSFMLKKECALADVV QKQQMTCSE*" gene complement(3625221..3625382) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" promotor_-10 complement(3625473..3625492) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3625493) /Source="Nicolas_upshifts" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" promotor_-35 complement(3625508..3625512) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3625597..3626562) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" /EC_number="3.1.3.11" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose 1,6-bisphosphatase class II" /protein_id="NP_391590.1" /db_xref="EnsemblGenomes-Gn:BSU37090" /db_xref="EnsemblGenomes-Tr:CAB15726" /db_xref="GOA:Q03224" /db_xref="InterPro:IPR004464" /db_xref="SubtiList:BG10415" /db_xref="UniProtKB/Swiss-Prot:Q03224" /translation="MERSLSMELVRVTEAAALASARWMGRGKKDEADEAATSAMRDVF DTVPMKGTVVIGEGEMDEAPMLYIGEKLGNGYGPRVDVAVDPLEGTNILASGGWNALT VIAVADHGTLLNAPDMYMQKIAVGPEAVGCIDIEAPVIDNLKAVAKAKNKDVEDVVAT ILNRERHAKIISELREAGARIKLINDGDVAGAINTAFDHTGVDILFGSGGAPEGVLSA VALKALGGEIIGKLLPQSEEEITRCHKMGLDLSKVLRMEDLVKGDDAIFAATGVTDGE LLKGVQFKGSVGTTESLVIRAKSGTVRFVDGRHSLKKKPNLVIRP*" gene complement(3625597..3626562) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" downshifts complement(3625603) /Source="Nicolas_upshifts" /id="D1918" /incds=0 /nref=56 /ntot=196 /MaxReadThrough="5.42698" /MaxDrop="5.21817" /score="-2.15106481" /energy="-10.2" /TU="U2921,U2922" /idTUdmin="U2922" /TUdmin="-88" /isTUend="FALSE" promotor_-35 3626179..3626188 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3626201..3626220 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3626209 /Source="Nicolas_upshifts" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3626593..3627882) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" /EC_number="2.5.1.7" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14763982, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14763982, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391591.2" /db_xref="EnsemblGenomes-Gn:BSU37100" /db_xref="EnsemblGenomes-Tr:CAB15727" /db_xref="GOA:P19670" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10414" /db_xref="UniProtKB/Swiss-Prot:P19670" /translation="MEKLNIAGGDSLNGTVHISGAKNSAVALIPATILANSEVTIEGL PEISDIETLRDLLKEIGGNVHFENGEMVVDPTSMISMPLPNGKVKKLRASYYLMGAML GRFKQAVIGLPGGCHLGPRPIDQHIKGFEALGAEVTNEQGAIYLRAERLRGARIYLDV VSVGATINIMLAAVLAEGKTIIENAAKEPEIIDVATLLTSMGAKIKGAGTNVIRIDGV KELHGCKHTIIPDRIEAGTFMIAGAAMGKEVIIDNVIPTHLESLTAKLREMGYHIETS DDQLLIVGGQKNLKPVDVKTLVYPGFPTDLQQPMTALLTRAKGTSVVTDTIYSARFKH IDELRRMGANMKVEGRSAIITGPVELQGAKVKASDLRAGACLVVAGLMADGVTEITGL EHIDRGYSSLEKKLEGLGATIWRERMTDEEIEQLQNS*" gene complement(3626593..3627882) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" S_feature complement(3627883..3628242) /Source="Nicolas_S_feature" /locus_tag="new_3807376_3807735_c" /HighExp="dia5, Fru, UNK1, Glucon, HiOs, T-5.40H, nit, SMM, MG 120, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16076699999999999" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1437" CDS complement(3628261..3628899) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" /EC_number="2.2.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 12469342, 22212631, 23468065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 12469342, 22212631, 23468065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transaldolase" /protein_id="NP_391592.3" /db_xref="EnsemblGenomes-Gn:BSU37110" /db_xref="EnsemblGenomes-Tr:CAB15728" /db_xref="GOA:P19669" /db_xref="InterPro:IPR001585" /db_xref="InterPro:IPR004731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018225" /db_xref="InterPro:IPR022999" /db_xref="InterPro:IPR033919" /db_xref="PDB:3R8R" /db_xref="SubtiList:BG10413" /db_xref="UniProtKB/Swiss-Prot:P19669" /translation="MLFFVDTANIDEIREANELGILAGVTTNPSLVAKEANVSFHDRL REITDVVKGSVSAEVISLKAEEMIEEGKELAKIAPNITVKIPMTSDGLKAVRALTDLG IKTNVTLIFNANQALLAARAGATYVSPFLGRLDDIGHNGLDLISEVKQIFDIHGLDTQ IIAASIRHPQHVTEAALRGAHIGTMPLKVIHALTKHPLTDKGIEQFLADWNK*" gene complement(3628261..3628899) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" downshifts complement(3628287) /Source="Nicolas_upshifts" /id="D1919" /incds=0 /nref=6 /ntot=65 /MaxReadThrough="6.97243" /MaxDrop="4.038" /score="-6.93331064" /energy="-18.4" /TU="U2921,U2922" /idTUdmin="U2926" /TUdmin=1716 /isTUend="FALSE" S_feature complement(3628900..3629018) /Source="Nicolas_S_feature" /locus_tag="new_3808393_3808511_c" /HighExp="dia5, LBGtran, M40t45, Lbtran, Mt0, M40t90, M0t45, Lbstat, Lbexp, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1438" CDS complement(3629019..3629876) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" /EC_number="4.1.2.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphate aldolase" /protein_id="NP_391593.1" /db_xref="EnsemblGenomes-Gn:BSU37120" /db_xref="EnsemblGenomes-Tr:CAB15729" /db_xref="GOA:P13243" /db_xref="InterPro:IPR000771" /db_xref="InterPro:IPR011289" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10412" /db_xref="UniProtKB/Swiss-Prot:P13243" /translation="MPLVSMTEMLNTAKEKGYAVGQFNLNNLEFTQAILQAAEEEKSP VILGVSEGAGRYMGGFKTVVAMVKALMEEYKVTVPVAIHLDHGSSFESCAKAIHAGFT SVMIDASHHPFEENVATTAKVVELAHFHGVSVEAELGTVGGQEDDVIAEGVIYADPKE CQELVERTGIDCLAPALGSVHGPYKGEPNLGFKEMEEIGKSTGLPLVLHGGTGIPTAD IKKSISLGTAKINVNTENQISSAKAVRETLAAKPDEYDPRKYLGPAREAIKETVIGKM REFGSSNQA*" gene complement(3629019..3629876) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" S_feature complement(3629877..3630003) /Source="Nicolas_S_feature" /locus_tag="new_3809370_3809496_c" /HighExp="C90, Lbtran, LBGtran, dia5, LBGexp, aero, M0t90, Glu, Lbexp, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1439" promotor_-10 complement(3629985..3630004) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-10" upshifts complement(3630003) /Source="Nicolas_upshifts" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" promotor_-35 complement(3630018..3630025) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-35" CDS complement(3630057..3630431) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator of sporulation initiation" /protein_id="NP_391594.1" /db_xref="EnsemblGenomes-Gn:BSU37130" /db_xref="EnsemblGenomes-Tr:CAB15730" /db_xref="GOA:P06628" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="PDB:1F51" /db_xref="PDB:1FSP" /db_xref="PDB:1NAT" /db_xref="PDB:1PEY" /db_xref="PDB:1PUX" /db_xref="PDB:1SRR" /db_xref="PDB:2FSP" /db_xref="PDB:2FTK" /db_xref="PDB:2JVI" /db_xref="PDB:2JVJ" /db_xref="PDB:2JVK" /db_xref="PDB:3Q15" /db_xref="SubtiList:BG10411" /db_xref="UniProtKB/Swiss-Prot:P06628" /translation="MMNEKILIVDDQYGIRILLNEVFNKEGYQTFQAANGLQALDIVT KERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVIIMTAYGELDMIQESKELGALTHF AKPFDIDEIRDAVKKYLPLKSN*" gene complement(3630057..3630431) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" promotor_-10 complement(3630471..3630489) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3630485) /Source="Nicolas_upshifts" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" S_feature complement(3630487..3631126) /Source="Nicolas_S_feature" /locus_tag="new_3809980_3810619_c" /HighExp="dia15, Diami, dia5, G135, Etha, G150, G180, Salt, H2O2, Paraq" /AntisenseName="ywjG" /AntisenseCor="0.58536525532649697" /AntisenseRegPval="-25.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1440" promotor_-35 3630488..3630491 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3630500..3630508) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" promotor_-10 3630507..3630526 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3630520 /Source="Nicolas_upshifts" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" promotor_-35 3630534..3630539 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3630555..3630574 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3630565 /Source="Nicolas_upshifts" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" CDS 3630597..3631118 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391595.1" /db_xref="EnsemblGenomes-Gn:BSU37140" /db_xref="EnsemblGenomes-Tr:CAB15731" /db_xref="InterPro:IPR019676" /db_xref="SubtiList:BG11053" /db_xref="UniProtKB/Swiss-Prot:P06629" /translation="MLKIFTTQLTGIFSRIQDKESDAIEDGARLLAQAVISGHSIYLY GANELQGVFYEATESKEPFPSVKAFPENAEEVTESDRVLMFCSGTGTAEEQELAKELY EKGAGVVCVSPAAKDSAGIEQYCDVHIDSKLKMPLVPDEDGTRYGFPSLMTALYVYHA LSFTLKEILQEYA*" gene 3630597..3631118 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" promotor_-35 3631061..3631064 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3631079..3631098 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3631093 /Source="Nicolas_upshifts" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3631116..3631135) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3631126) /Source="Nicolas_upshifts" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" downshifts 3631137 /Source="Nicolas_upshifts" /id="D1920" /incds=0 /nref=191 /ntot=242 /MaxReadThrough="1.98527" /MaxDrop="5.8354" /score="11.5531593" /energy="-11.9" /TU="NA" /idTUdmin="U2923" /TUdmin=0 /isTUend="TRUE" promotor_-35 complement(3631150..3631157) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" CDS complement(3631200..3632807) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" /EC_number="6.3.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11544212, 15252202, 17158658, 17302819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544212, 15252202, 17158658, 17302819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CTP synthetase" /protein_id="NP_391596.1" /db_xref="EnsemblGenomes-Gn:BSU37150" /db_xref="EnsemblGenomes-Tr:CAB15743" /db_xref="GOA:P13242" /db_xref="InterPro:IPR004468" /db_xref="InterPro:IPR017456" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033828" /db_xref="SubtiList:BG10410" /db_xref="UniProtKB/Swiss-Prot:P13242" /translation="MTKYIFVTGGVVSSLGKGIVAASLGRLLKNRGLNVTIQKFDPYI NVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDINLNKFSNVTTGKIYSTVLKKE RRGDYLGGTVQVIPHITNELKDRVYRAGKETNADVVITEIGGTVGDIESLPFLEAIRQ MKSDIGRENVMYIHCTLVPYIKAAGELKTKPTQHSVKELRSLGIQPNIIVVRTEMPIS QDMKDKIALFCDIDTKAVIECEDADNLYSIPLELQKQGLDKLVCEHMKLACKEAEMSE WKELVNKVSNLSQTITIGLVGKYVELPDAYISVVESLRHAGYAFDTDVKVKWINAEEV TENNIAELTSGTDGIIVPGGFGDRGVEGKIVATKYARENNIPFLGICLGMQVASIEYA RNVLGLKGAHSAEIDPSTQYPIIDLLPEQKDVEDLGGTLRLGLYPCKLEEGTKAFEVY QDEVVYERHRHRYEFNNEFRQQMEEQGFVFSGTSPDGRLVEIIELKDHPWFVASQFHP EFKSRPTRPQPLFKGFIGASVEAANQK*" gene complement(3631200..3632807) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" downshifts complement(3631213) /Source="Nicolas_upshifts" /id="D1921" /incds=0 /nref=222 /ntot=259 /MaxReadThrough="2.2929" /MaxDrop="8.17874" /score="18.9699606" /energy="-12.1" /TU="NA" /idTUdmin="U2927" /TUdmin=0 /isTUend="TRUE" S_feature complement(3632808..3632995) /Source="Nicolas_S_feature" /locus_tag="new_3812301_3812488_c" /HighExp="LBGexp, Lbexp, dia0, G150, G135, G180, Paraq, Oxctl, dia15, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1441" promotor_-10 complement(3632983..3633002) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3632995) /Source="Nicolas_upshifts" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" promotor_-35 complement(3633017..3633024) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3633049..3633570) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase (delta subunit) and transcriptional repressor" /protein_id="NP_391597.1" /db_xref="EnsemblGenomes-Gn:BSU37160" /db_xref="EnsemblGenomes-Tr:CAB15744" /db_xref="GOA:P12464" /db_xref="InterPro:IPR007759" /db_xref="InterPro:IPR029757" /db_xref="PDB:2KRC" /db_xref="PDB:2M4K" /db_xref="PDB:4NC7" /db_xref="PDB:4NC8" /db_xref="SubtiList:BG10409" /db_xref="UniProtKB/Swiss-Prot:P12464" /translation="MGIKQYSQEELKEMALVEIAHELFEEHKKPVPFQELLNEIASLL GVKKEELGDRIAQFYTDLNIDGRFLALSDQTWGLRSWYPYDQLDEETQPTVKAKKKKA KKAVEEDLDLDEFEEIDEDDLDLDEVEEELDLEADDFDEEDLDEDDDDLEIEEDIIDE DDEDYDDEEEEIK*" gene complement(3633049..3633570) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" downshifts complement(3633105) /Source="Nicolas_upshifts" /id="D1922" /incds=0 /nref=7 /ntot=182 /MaxReadThrough="6.49215" /MaxDrop="3.2129" /score="19.8764263" /energy="-19.4" /TU="U2928,U2929" /idTUdmin="U2927" /TUdmin="-1892" /isTUend="FALSE" S_feature complement(3633571..3633673) /Source="Nicolas_S_feature" /locus_tag="new_3813064_3813166_c" /HighExp="H2O2, Paraq, Oxctl, LBGexp, G180, dia15, dia0, Lbexp, BMM, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1442" promotor_-10 complement(3633654..3633673) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3633673) /Source="Nicolas_upshifts" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" S_feature complement(3633675..3633752) /Source="Nicolas_S_feature" /locus_tag="new_3813168_3813245_c" /HighExp="T0.30H, S8, S7, S6, S4, S3, S5, Sw, BC, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1443" promotor_-35 complement(3633689..3633692) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3633753..3634892) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase" /protein_id="NP_391598.1" /db_xref="EnsemblGenomes-Gn:BSU37170" /db_xref="EnsemblGenomes-Tr:CAB15745" /db_xref="GOA:P45867" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG11239" /db_xref="UniProtKB/Swiss-Prot:P45867" /translation="MNFSLSEEHEMIRKLVRDFAKHEVAPTAAERDEQERFDRELFRE MANLGLTGIPWPEDYGGIGSDYLAYVIAVEELSKVCASTGVTLSAHISLCSWPLFAFG TEEQKTEYLTQLALGEKIGAFALTEAGSGSDAGSMKTTAERIGDDYVLNGSKVFITNG GVADIYIVFAVTDPEKKKKGVTAFIVEKDFEGFFTGKKEKKLGIRSSPTTEIMFEDCV VPASKRLGEEGEGFKIAMKTLDGGRNGIAAQAVGIAQGALDAALQYAKERKQFGKSIA EQQGIAFKLADMATMIEASRLLTYQAAWLESSGLPYGKASAMSKLMAGDTAMKVTTEA VQIFGGYGYTKDYPVERYMRDAKITQIYEGTQEIQRLVISRMLAD*" gene complement(3633753..3634892) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" CDS complement(3634889..3637006) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative iron-sulphur-binding reductase" /protein_id="NP_391599.1" /db_xref="EnsemblGenomes-Gn:BSU37180" /db_xref="EnsemblGenomes-Tr:CAB15746" /db_xref="GOA:P45866" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11311" /db_xref="UniProtKB/Swiss-Prot:P45866" /translation="MSGFLIANALLFLIVTAYAVYLFVYLVKTRLAYIKLGQKEQFDQ RFKERLHAIWVNVFGQKKLLKDKKSGIIHVMFFYGFILVQFGAIDFIIKGLAPGRNLS LGPVYPAFTFFQEIVTFLILIAVGWAFYRRYIEKLVRLKRGFKAGLVLIFIGGLMLTV LLGNGMNLIWHEHGLSWSEPIASGIAFMLSGVGKTGAAVIFYIAWWIHLLFLLSFLVY VPQSKHAHLIAGPANVFFNRMESAGKLEKIDFTDETKESYGAGKIEDFRQSQLLDLYA CVECGRCTNMCPATGTGKMLSPMDLILRLRDHLTEKGAAVTSRSPWVPAAAFRHTRGN QLAAASAGSGSQEAAAALDYNPSLIGDVITEEEIWACTTCRNCEDQCPVMNEHVDKII DLRRYLVLTEGKMDSDAQRAMTSIERQGNPWGLNRKERENWRDEAPDAEIPTVKEMKK EGKEFEYLFWVGSMGSYDNRSQKIAISFAKLLNHAGVSFAILGNKEKNSGDTPRRLGN EFLFQELAEKNISEFEKNDVKKIVTIDPHAYNLFKNEYPDFGFEGEVYHHTEVLAELV KNGKLRPQHPLHETITFHDSCYLGRYNEVYDPPREILKAIPGVQLVEMERSRETGMCC GAGGGLMWMEEETGNRINVARTEQALAVNPSVISSGCPYCLTMLGDGTKAKEAEDQVK TYDVVELLAQSVLGADLKMGEKQ*" gene complement(3634889..3637006) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" S_feature complement(3637007..3637065) /Source="Nicolas_S_feature" /locus_tag="new_3816500_3816558_c" /HighExp="T0.30H, S6, BC, S8, S7, Sw, S5, S4, Lbstat, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1444" promotor_-10 complement(3637066..3637085) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3637079) /Source="Nicolas_upshifts" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" promotor_-35 complement(3637099..3637106) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3637105..3637111 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3637125..3637136 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3637130 /Source="Nicolas_upshifts" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" CDS 3637161..3638357 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14973018, 16514141, 18820022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16514141, 18820022; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase (phospholipase D family)" /protein_id="NP_391600.1" /db_xref="EnsemblGenomes-Gn:BSU37190" /db_xref="EnsemblGenomes-Tr:CAB15747" /db_xref="GOA:P45865" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="SubtiList:BG11310" /db_xref="UniProtKB/Swiss-Prot:P45865" /translation="MKVFIVIMIIVVIFFALILLDIFMGRAGYRKKAYEPVFSKKKSD IELIHCGADLVERMMNDIRQAASSVHMMFFIMKNDEVSHNMYTLLKTKAQAGVSVYLL LDWAGCRAIKKTALQTMKNAGVHVHVMNRPRFPFFFFHMQKRNHRKITVIDGKIGYIG GFNIAEEYLGKKAKFGNWEDYHLRMIGEGVHDLQTLFASDLKRNTGIELGSDVWPKLQ QGTISHKIYATDGYSLENIYLANIAQAKNRLTVCTPYYIPSKPLQEALINARKNGVSV RIIVPMKSDHPLVREAAFTYYSELLDAGCLIYRYYQGFYHVKALIIDDHLSIIGTANF DKRSLFLNEEVNVEIDDEAFTSEVYATIEEDMKKSELLTMEDFSKRTFRQRPAEWLGR ALSYFL*" gene 3637161..3638357 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" S_feature complement(3637353..3638231) /Source="Nicolas_S_feature" /locus_tag="new_3816846_3817724_c" /HighExp="S4, S5, S3, S6, S7, S8, BT, B36, LoTm, B60" /AntisenseName="clsB" /AntisenseCor="0.84883232203587" /AntisenseRegPval="-75.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1445" promotor_-10 complement(3638221..3638239) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3638232) /Source="Nicolas_upshifts" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" promotor_-35 complement(3638255..3638260) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3638370..3639332 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" /EC_number="3.-.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8614629, 22961846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8614629, 22961846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UV DNA damage repair endonuclease" /protein_id="NP_391601.1" /db_xref="EnsemblGenomes-Gn:BSU37200" /db_xref="EnsemblGenomes-Tr:CAB15748" /db_xref="GOA:P45864" /db_xref="InterPro:IPR004601" /db_xref="InterPro:IPR023520" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11309" /db_xref="UniProtKB/Swiss-Prot:P45864" /translation="MIFRFGFVSNAMSLWDASPAKTLTFARYSKLSKTERKEALLTVT KANLRNTMRTLHYIIGHGIPLYRFSSSIVPLATHPDVMWDFVTPFQKEFREIGELVKT HQLRTSFHPNQFTLFTSPKESVTKNAVTDMAYHYRMLEAMGIADRSVINIHIGGAYGN KDTATAQFHQNIKQLPQEIKERMTLENDDKTYTTEETLQVCEQEDVPFVFDFHHFYAN PDDHADLNVALPRMIKTWERIGLQPKVHLSSPKSEQAIRSHADYVDANFLLPLLERFR QWGTNIDFMIEAKQKDKALLRLMDELSSIRGVKRIGGGALQWKS*" gene 3638370..3639332 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" promotor_-35 3639346..3639352 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3639367..3639385 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3639367 /Source="Nicolas_upshifts" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" CDS 3639413..3639685 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391602.1" /db_xref="EnsemblGenomes-Gn:BSU37210" /db_xref="EnsemblGenomes-Tr:CAB15749" /db_xref="InterPro:IPR035895" /db_xref="SubtiList:BG11308" /db_xref="UniProtKB/Swiss-Prot:P45863" /translation="MKNIKSLKVAAQAFTLRNLIHLYKMCHSGSHEVYIYSKKTMCKI KSLIELETFRMAHNEKEYLIVVEGTKASQLIEKFQNLIEPAEREAL*" gene 3639413..3639685 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" downshifts complement(3639419) /Source="Nicolas_upshifts" /id="D1923" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="1.03516" /MaxDrop="5.08765" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=330 /isTUend="FALSE" downshifts 3639675 /Source="Nicolas_upshifts" /id="D1924" /incds=0 /nref=54 /ntot=128 /MaxReadThrough="4.49396" /MaxDrop="7.49636" /score="14.0189582" /energy="-10" /TU="U2932" /idTUdmin="U2930" /TUdmin=178 /isTUend="FALSE" S_feature 3639720..3640126 /Source="Nicolas_S_feature" /locus_tag="new_3819213_3819619" /HighExp="Etha, C30, Sw, Gly, C90, M/G, BC, Salt, Fru, G135" /AntisenseName="ywjB" /AntisenseCor="0.2646821361217" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1446" CDS complement(3639727..3640251) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391603.1" /db_xref="EnsemblGenomes-Gn:BSU37220" /db_xref="EnsemblGenomes-Tr:CAB15750" /db_xref="GOA:P45862" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG11307" /db_xref="UniProtKB/Swiss-Prot:P45862" /translation="MERKTVLYIAVSLDGMIAKEDGSIDWLDEFEGEGDNGYSDFYQT VDTVILGRSTYEHVKVLTPVFPYQDKTCYVFTGSPDSYQDEHVTFINEGARAFTARLK QEKGSNIWIAGGAELVNDFMKEDAIDEFIITVIPVVLGSGIPLFHELTNETKLRLKGT KQFGQAVQLHYVRA*" gene complement(3639727..3640251) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" downshifts complement(3639749) /Source="Nicolas_upshifts" /id="D1925" /incds=0 /nref=194 /ntot=239 /MaxReadThrough="1.38978" /MaxDrop="6.19859" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=0 /isTUend="TRUE" CDS complement(3640261..3641988) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12119303, 12354229, 25652542; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC lipid transporter (ATP-binding protein)" /protein_id="NP_391604.1" /db_xref="EnsemblGenomes-Gn:BSU37230" /db_xref="EnsemblGenomes-Tr:CAB15751" /db_xref="GOA:P45861" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11306" /db_xref="UniProtKB/Swiss-Prot:P45861" /translation="MLRQFFSYYKPYKTLFFLDFFSAIAGGLMELSFPLIVNYFIDTL LPGRDWGLIIATSIGLFAVYALSSALQYIVTYWGHMLGINIETDMRKSLFDHLQKLSF KFYDNNKTGTLMSKLTNDLMYIGEVAHHGPEDLFIAVMTILGAFGVMLFINWQLALLT FIIMPIVIWLALYFNKKMTKAFTTLNKDIGDFSARVENNIGGIRLVQAFGNEAFEKER FAVNNQRFRVTKLSSYKIMAKNGSISYMLTRFVTLFVLLCGTWFVIRGSLSYGEFVAF VLLTNVLFRPIDKINAIIEMYPRGIAGFKSYMELMETEPDIQDSPDSKDVSGLKGNIR YKHVSFGYDDHHNVLNDINLSIQAGETVAFVGPSGAGKSTLCSLLPRFYEASEGDITI DGISIKDMTLSSLRGQIGVVQQDVFLFSGTLRENIAYGRLGASEEDIWQAVKQAHLEE LVHNMPDGLDTMIGERGVKLSGGQKQRLSIARMFLKNPSILILDEATSALDTETEAAI QKALQELSEGRTTLVIAHRLATIKDADRIVVVTNNGIEEQGRHQDLIEAGGLYSRLHQ AQFGQMVHR*" gene complement(3640261..3641988) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" promotor_-10 complement(3642022..3642041) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3642036) /Source="Nicolas_upshifts" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" promotor_-35 complement(3642055..3642061) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3642077..3643579) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" /EC_number="2.7.8.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14973018, 15743965, 16514141, 26025016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase" /protein_id="NP_391605.1" /db_xref="EnsemblGenomes-Gn:BSU37240" /db_xref="EnsemblGenomes-Tr:CAB15752" /db_xref="GOA:P45860" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG11305" /db_xref="UniProtKB/Swiss-Prot:P45860" /translation="MLKRRLEFFFLYMMLIGAYVIWFFPVSRLEFYGGLLCYISIILF SIYSLILENRTSQHTLLWIHILVFFPIVGYVFYLFSGQLYVKGKLFKTKRMYNREKLR KLFDKEETPEVTGLKDNQERFFTYSIRAAHMNINTKSNIKVLKNGEETFPDIFKAMRK AESYIHIEYYMFKSDMLGRGMMDIMMEKARQGVEVRFLYDAAGSMKLARRDIMRMKQA GVDIVPFSPLKYGFFNQKLNFRNHRKIVIIDGKTGFVGGLNVGKEYISRDPYIGFWRD THLRLEGEIVQTLHAIFMLDWEYVSNEVLIDQEEYNTPVPVEGGGIYQIVATGPDMKE SMSDLYYEMISSAQKSIWIATPYFVPNESIRTALKAAATKGVEVRVMVPEKNDSFLTQ YASRSYFPELLLEGIEVYSYQKGFMHQKVMIIDGDLASVGTANMDMRSFQLNFEVNVF FTDAEAIRTLEAHFEEDMQESEKLSPVGFYKRGVADRTKESFARLFSGVL*" gene complement(3642077..3643579) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" promotor_-10 complement(3643603..3643621) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3643621) /Source="Nicolas_upshifts" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" promotor_-35 complement(3643636..3643642) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3643666..3644038) /Source="Nicolas_S_feature" /locus_tag="new_3823159_3823531_c" /HighExp="Lbtran, M40t45, nit, LBGtran, LBGstat, S0, ferm, M0t45, Lbstat, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30294500000000002" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S1447" downshifts complement(3643709) /Source="Nicolas_upshifts" /id="D1926" /incds=0 /nref=4 /ntot=19 /MaxReadThrough="2.94229" /MaxDrop="4.09744" /score="13.5274489" /energy="-11.4" /TU="NA" /idTUdmin="U2935" /TUdmin=0 /isTUend="TRUE" CDS complement(3644065..3644736) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (gamma subunit)" /protein_id="NP_391606.1" /db_xref="EnsemblGenomes-Gn:BSU37250" /db_xref="EnsemblGenomes-Tr:CAB15753" /db_xref="GOA:P42177" /db_xref="InterPro:IPR003816" /db_xref="InterPro:IPR023234" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11084" /db_xref="UniProtKB/Swiss-Prot:P42177" /translation="MSGQILWGIMPYIVLTIFIGGHIYRYQHDQFGWTAKSSELLEKK KLAAGSTLFHWGLLCVVGGHVMGILIPEGVYASLGISEHMYHKMAIGAGLPAGIAACT GLVILTYRRLFDKRIRKTSSPSDILTLLLLLFMMLSGVAATFLNIDSKGFDYRTTVGP WFREIVLFRPDASLMESVPLWFKFHIVIGYVVFILWPFTRLVHVFSLPLKYLTRSYVV YRKRS*" gene complement(3644065..3644736) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" downshifts complement(3644083) /Source="Nicolas_upshifts" /id="D1927" /incds=0 /nref=4 /ntot=13 /MaxReadThrough="6.70789" /MaxDrop="4.50566" /score="27.8375931" /energy="-11.7" /TU="U2935" /idTUdmin="U2935" /TUdmin="-374" /isTUend="FALSE" CDS complement(3644733..3645287) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase molybdenum cofactor assembly chaperone NarJ" /protein_id="NP_391607.1" /db_xref="EnsemblGenomes-Gn:BSU37260" /db_xref="EnsemblGenomes-Tr:CAB15754" /db_xref="GOA:P42178" /db_xref="InterPro:IPR003765" /db_xref="InterPro:IPR020945" /db_xref="InterPro:IPR036411" /db_xref="SubtiList:BG11083" /db_xref="UniProtKB/Swiss-Prot:P42178" /translation="MNTTDRQITFSALSCLLSYPDEEWRAELPDWKALIQEIGNRQIR EKLLHFFETSASYSPEALIEHYVYTFDFGKKTNMYVTYFNSGEQRERGIELLHLKNTY EQSGFLPTEKELPDYLPLMLEFAAAAEIEAARSVFEKYLSNVRELASRLEKNDSIYAE LLHVLLAALENIGVRESVEGAVQA*" gene complement(3644733..3645287) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" CDS complement(3645313..3646776) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (beta subunit)" /protein_id="NP_391608.1" /db_xref="EnsemblGenomes-Gn:BSU37270" /db_xref="EnsemblGenomes-Tr:CAB15755" /db_xref="GOA:P42176" /db_xref="InterPro:IPR006547" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR029263" /db_xref="SubtiList:BG11082" /db_xref="UniProtKB/Swiss-Prot:P42176" /translation="MKIKAQIGMVMNLDKCIGCHTCSVTCKNTWTNRSGAEYMYFNNV ETKPGIGYPKQWEDQDKYKGGWTLKKGKLELKSGSKTNRLAGLFYNPNQPSIDDYYEP WNYDYETLTNSPQKKHQPVARPKSSLTGDFMNIEWGPNWEDDLAGGHITGLEDPNVQK MEESIKTEFDDVFMMYLPRICEHCINPACVSSCPSGAMYKREEDGIVLVDQNACRSWR YCVSSCPYKKVYFNWQTNKAEKCTLCFPRLEAGLPTICSETCVGRIRYLGVMLYDADK VEEAASVENEKDLYHSQLDVFLDPNDPEVAKLAKEQGIPAEWIEAAQQSPIYKMIIDW KIALPLHPEYRTLPMVWYIPPLSPIMNLFEGKGSRQTAEDIFPAIDQMRIPIDYLAQL LTAGDTDHIRSTLKKMSVMRQYMRAVQTNKSIDPELISSVGLTEQQIEDMYRLLAIAK YDDRFVIPSSHREEVSDLYAEQGSCGLSFSGGPGSCF*" gene complement(3645313..3646776) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" CDS complement(3646766..3650452) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" /EC_number="1.7.5.1" /EC_number="1.7.99.4" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11289299, 7557333, 7860592, 8846791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (alpha subunit)" /protein_id="NP_391609.2" /db_xref="EnsemblGenomes-Gn:BSU37280" /db_xref="EnsemblGenomes-Tr:CAB15756" /db_xref="GOA:P42175" /db_xref="InterPro:IPR006468" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="InterPro:IPR028189" /db_xref="SubtiList:BG11081" /db_xref="UniProtKB/Swiss-Prot:P42175" /translation="MKKKKRSPLFRRLNYFSPIEHHSNKHSQTTREDRDWENVYRNRW QYDKVVRSTHGVNCTGSCSWNIYVKNGIVTWEGQNLNYPSTGPDMPDFEPRGCPRGAS FSWYIYSPLRVKYPYVRGVLINLWREALQTHQNPLEAWKSIVENPEKAKSYKQARGKG GFVRAEWPEVLKLISASLLYTVMKYGPDRNVGFSPIPAMSMISHASGSRFMSLIGGPM LSFYDWYADLPPASPQIWGDQTDVPESSDWYNSGYIITWGSNVPLTRTPDAHFLAEAR YKGAKVISISPDFAESSKFADDWLSIRQGTDGALAMAMGHVILQEFYVNQETERFIEY AKQYTDFPFLVTLSKENGVYTAGRFLHAKDIGRKTKHDQWKPAVWDEQTSSFAIPQGT MGSRWDGQQKWNLHMIDEETGEPIEPRLSVLGIEDEIGTVRIPYFSNDGNKVLERDLP IKKMNLNGEETYITTVFDLILANYGVNRGIGERSAVSYDDPEPFTPAWQEQMTGIKKE AVVKIAREFAQNAIDTDGRSMIIVGAGINHWFNSDTIYRAVLNLVLLVGAQGVNGGGW AHYVGQEKLRPAEGWQTIATAKDWEGVPKLQNGTSFFYFATDQWRYEDQPISDLASPI AASSRYKHHADYNVLAARLGWLPSYPTFNQNGIDLYKEAEKAGAATPEDVGAYVASQL QEKKLKFAIEDPDNEVNFPRNLFVWRANLISSSGKGHEYFLKHLLGTTNGLMNDDSDS IRPEEIKWREQAPEGKLDLLINLDFRMAGTALYSDIVLPAATWYEKHDLSSTDMHPFI HPFAPAISAPWESKSDWDIFKALSKAVSDLAEEVDMEPVKEVVATPLLHDTMQELAQP FGKINDWSKGECEAIPGKTMPNIQVVERDYKHIFHKMTALGPNVALKPSGTKGMSWSI ADEYESLKQRLGEITSDSVAKGCPNISEAKQAAEAILTLSSTSNGKVAVKAWESLENI TNLKLKDLAEEREEECFTFEQITAQPKTVITSPAFTGSEKGGRRYSPFTTNVEKLIPW RTLTGRQSYYVDHELMMEFGETMATFKPILQHRPFLSKRPDQEGKEIVLNYLTPHNKW SVHSMYFDSLPMLTLFRGGPTVWMNKDDAEDTDIKDNDWIECFNRNGVVVARAVLSHR IPKGMAFMHHAQDRHINVPGTKLTNNRGGTHNSPTRIHVKPTQMIGGYAQLSYGFNYY GPTGNQRDLNVVIRKLKEVDWLED*" gene complement(3646766..3650452) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" misc_feature complement(3650483..3650502) /Source="Nicolas_upshift_promotors" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3650507) /Source="Nicolas_upshifts" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" S_feature complement(3650509..3650638) /Source="Nicolas_S_feature" /locus_tag="new_3830002_3830131_c" /HighExp="Lbtran, M40t45, LBGtran, ferm, M0t45, nit, S0, Lbstat, LBGstat, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1448" CDS complement(3650648..3651124) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 11698370, 16428414, 22178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 11698370, 16428414, 22178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_391610.1" /db_xref="EnsemblGenomes-Gn:BSU37290" /db_xref="EnsemblGenomes-Tr:CAB15757" /db_xref="GOA:P46910" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018490" /db_xref="SubtiList:BG11345" /db_xref="UniProtKB/Swiss-Prot:P46910" /translation="MNQCDYLLFLKQLPMFNEVPLSIVETLLKNGTFIRGSCDQSPSF LHSQSVYIVLKGSVRFMDTRLPEGSKTVALWEKGDVFPIDEKGGLYLSPFISVNATSD ILILNIPYYIFKKMMSYHPQLQMNFLAMLQQNVFCSYQLFLRYLHTSQDENAEPGS*" gene complement(3650648..3651124) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" downshifts complement(3650683) /Source="Nicolas_upshifts" /id="D1928" /incds=0 /nref=10 /ntot=39 /MaxReadThrough="5.03469" /MaxDrop="3.83412" /score="30.7487171" /energy="-10.5" /TU="U2936" /idTUdmin="U2936" /TUdmin="-154" /isTUend="FALSE" promotor_-10 complement(3651147..3651166) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-10" upshifts complement(3651159) /Source="Nicolas_upshifts" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" promotor_-35 complement(3651181..3651184) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-35" upshifts 3651231 /Source="Nicolas_upshifts" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" misc_feature 3651234..3651253 /Source="Nicolas_upshift_promotors" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3651268..3651987 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16428414, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391611.1" /db_xref="EnsemblGenomes-Gn:BSU37300" /db_xref="EnsemblGenomes-Tr:CAB15758" /db_xref="GOA:P46909" /db_xref="InterPro:IPR025576" /db_xref="SubtiList:BG11344" /db_xref="UniProtKB/Swiss-Prot:P46909" /translation="MKALIPKQHGAWAMLLIPFLLGMVKGGPVIWHIPLFLGWLFLYL AVYPVTLALKKKQSKPYQKWMCYYGFPTCCFLMISVFHKPPLIWVGVSLLPLFLIHMY FARRKNERALLNDVAGVLFFCSGGFASCWLGMGTLDGWAWFIFLQSALFFIGSSFYVK SVIRERKNRAFAYWSWGYHLLLPFLSALFGAGWAFLAFIPSSLRAWFFHGRDWPVKTI GILEIVNACFFLAVMCLFITR*" gene 3651268..3651987 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" downshifts 3651971 /Source="Nicolas_upshifts" /id="D1929" /incds=0 /nref=14 /ntot=34 /MaxReadThrough="2.00369" /MaxDrop="5.63285" /score="-3.54009378" /energy="-5.8" /TU="NA" /idTUdmin="U2937" /TUdmin=0 /isTUend="TRUE" CDS complement(3652019..3652735) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 16796679, 21068385, 23046954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 16796679, 21068385, 23046954; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of anaerobic metabolism (FNR/CAP family)" /protein_id="NP_391612.1" /db_xref="EnsemblGenomes-Gn:BSU37310" /db_xref="EnsemblGenomes-Tr:CAB15759" /db_xref="GOA:P46908" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR012318" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018335" /db_xref="InterPro:IPR018490" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11343" /db_xref="UniProtKB/Swiss-Prot:P46908" /translation="MNFLSVRPSDSDLISSDLYELLESISTKRKMEKHTYLFREGMDA EELYLIQSGLIEIGKLTSDGKDLTLRICQKHDIVGELTLFTEEPRYMLSAKVLEDGEV LVINKNKLEKELIQNGALTFEFMKWMSTHLRKIQSKIRDLLLHGKKGALYSTLIRLSN SYGVERSDGILINIVLTNQDLAKFCAAARESVNRMLGDLRKKGVISIDESGKIILHKR DYLRCEIECENCPLEICNID*" gene complement(3652019..3652735) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" downshifts complement(3652021) /Source="Nicolas_upshifts" /id="D1930" /incds=0 /nref=116 /ntot=238 /MaxReadThrough="3.06242" /MaxDrop="8.21489" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-84" /isTUend="FALSE" downshifts complement(3652091) /Source="Nicolas_upshifts" /id="D1931" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.51297" /MaxDrop="3.71248" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-154" /isTUend="FALSE" misc_feature complement(3652761..3652780) /Source="Nicolas_upshift_promotors" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3652773) /Source="Nicolas_upshifts" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" CDS complement(3652834..3654021) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 15849754, 16796679, 16850406, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 15849754, 16796679, 16850406, 26786044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite extrusion permease" /protein_id="NP_391613.2" /db_xref="EnsemblGenomes-Gn:BSU37320" /db_xref="EnsemblGenomes-Tr:CAB15760" /db_xref="GOA:P46907" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11342" /db_xref="UniProtKB/Swiss-Prot:P46907" /translation="MINRQHIQLSLQSLSLVAGFMVWVLISSLISQITLDIHLSKGEI SLVTAIPVILGSLLRIPLGYLTNRFGARLMFMVSFILLLFPVFWISIADSLFDLIAGG FFLGIGGAVFSIGVTSLPKYYPKEKHGVVNGIYGAGNIGTAVTTFAAPVIAQAVGWKS TVQMYLILLAVFALLHVLFGDRHEKKVKVSVKTQIKAVYRNHVLWFLSLFYFITFGAF VAFTIYLPNFLVEHFGLNPADAGLRTAGFIAVSTLLRPAGGFLADKMSPLRILMFVFA GLTLSGIILSFSPTIGLYTFGSLTVAVCSGIGNGTVFKLVPFYFSKQAGIANGIVSAM GGLGGFFPPLILASVFQATGQYAIGFMALSEVALASFVLVIWMYWQERMKTHTERNSQ SIN*" gene complement(3652834..3654021) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" misc_feature complement(3654051..3654070) /Source="Nicolas_upshift_promotors" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3654069) /Source="Nicolas_upshifts" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" CDS complement(3654157..3655827) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" /EC_number="6.1.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8289305, 9862121" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8289305, 9862121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginyl-tRNA synthetase" /protein_id="NP_391614.1" /db_xref="EnsemblGenomes-Gn:BSU37330" /db_xref="EnsemblGenomes-Tr:CAB15761" /db_xref="GOA:P46906" /db_xref="InterPro:IPR001278" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR005148" /db_xref="InterPro:IPR008909" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR035684" /db_xref="InterPro:IPR036695" /db_xref="SubtiList:BG11341" /db_xref="UniProtKB/Swiss-Prot:P46906" /translation="MNIAEQMKDVLKEEIKAAVLKAGLAEESQIPNVVLETPKDKTHG DYSTNMAMQLARVAKKAPRQIAEEIVAHFDKGKASIEKLDIAGPGFINFYMNNQYLTK LIPSVLEAGEAYGETNIGNGERVQVEFVSANPTGDLHLGHARGAAVGDSLCNVLSKAG YDVSREYYINDAGNQINNLALSVEVRYFEALGLEKPMPEDGYRGEDIIAIGKRLAEEY GDRFVNEEESERLAFFREYGLKYELEKLRKDLENFRVPFDVWYSETSLYQNGKIDKAL EALREKGHVYEEDGATWFRSTTFGDDKDRVLIKKDGTYTYLLPDIAYHKDKLDRGFDK LINVWGADHHGYIPRMKAAIEALGYEKGTLEVEIIQLVHLYKNGEKMKMSKRTGKAVT MRDLIEEVGLDAVRYFFAMRSADTHMDFDLDLAVSTSNENPVYYAQYAHARICSMLRQ GEEQGLKPAADLDFSHIQSEKEYDLLKTIGGFPEAVAEAAEKRIPHRVTNYIYDLASA LHSFYNAEKVIDPENEEKSRARLALMKATQITLNNALQLIGVSAPEKM*" gene complement(3654157..3655827) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" downshifts complement(3654159) /Source="Nicolas_upshifts" /id="D1932" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="1.71727" /MaxDrop="6.56513" /score="23.3947976" /energy="-12.5" /TU="NA" /idTUdmin="U2941" /TUdmin=0 /isTUend="TRUE" CDS complement(3655824..3656252) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_391615.1" /db_xref="EnsemblGenomes-Gn:BSU37340" /db_xref="EnsemblGenomes-Tr:CAB15762" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR015231" /db_xref="PDB:1R0U" /db_xref="SubtiList:BG14161" /db_xref="UniProtKB/Swiss-Prot:O07624" /translation="MKQETPITLHVKSVIEDDGNQEVIEFRTTGFYYVKQNKVYLSYY EEHDLGKVKTIVKVSEGEVLVMRSGAVKMNQRFVTGASTIAKYKMSFGELELKTSTKS IQSDLDEEKGRISIAYDMHVGDEQEHLHNMTITYEGGTHA*" gene complement(3655824..3656252) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" misc_feature 3656320..3656334 /Source="Nicolas_upshift_promotors" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3656320..3656339) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3656327 /Source="Nicolas_upshifts" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(3656336) /Source="Nicolas_upshifts" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" promotor_-35 complement(3656356..3656359) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3656391..3656410) /Source="Nicolas_upshift_promotors" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3656403) /Source="Nicolas_upshifts" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" promotor_-35 3656483..3656490 /Source="Nicolas_upshift_promotors" /id="U2943" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1610 /SigmaFactorBS="tccgaaatctatcatttccttttcacatttttttcaaaatat atgTATTGAATtagtaatttgatAGTTTTAAGATAAAAGTACAacatagatctgctag a" /listShort="sboA, sboX, albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3656498 /Source="Nicolas_upshifts" /id="U2943" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1610 /SigmaFactorBS="tccgaaatctatcatttccttttcacatttttttcaaaatat atgTATTGAATtagtaatttgatAGTTTTAAGATAAAAGTACAacatagatctgctag a" /listShort="sboA, sboX, albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" promotor_-10 3656503..3656522 /Source="Nicolas_upshift_promotors" /id="U2943" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1610 /SigmaFactorBS="tccgaaatctatcatttccttttcacatttttttcaaaatat atgTATTGAATtagtaatttgatAGTTTTAAGATAAAAGTACAacatagatctgctag a" /listShort="sboA, sboX, albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 3656547 /Source="Nicolas_upshifts" /id="D1933" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="8.77621" /MaxDrop="1.77243" /score="6.03938699" /energy="-13.2" /TU="U2943" /idTUdmin="U2937" /TUdmin=4576 /isTUend="FALSE" CDS 3656565..3656696 /gene="sboA" /locus_tag="BSU_37350" /old_locus_tag="BSU37350" /function="16.8: Protect" /function="16.4: Excrete" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12696888, 15743949, 16095584, 17213266, 27914001" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12696888, 15743949, 16095584, 17213266, 27914001; Product type f: factor" /codon_start=1 /transl_table=11 /product="subtilosin A" /protein_id="NP_391616.1" /db_xref="EnsemblGenomes-Gn:BSU37350" /db_xref="EnsemblGenomes-Tr:CAB15763" /db_xref="GOA:O07623" /db_xref="InterPro:IPR021539" /db_xref="PDB:1PXQ" /db_xref="SubtiList:BG12671" /db_xref="UniProtKB/Swiss-Prot:O07623" /translation="MKKAVIVENKGCATCSIGAACLVDGPIPDFEIAGATGLFGLWG* " gene 3656565..3656696 /gene="sboA" /locus_tag="BSU_37350" /old_locus_tag="BSU37350" CDS 3656653..3656805 /gene="sboX" /locus_tag="BSU_37360" /old_locus_tag="BSU37360" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15743949; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin-like product" /protein_id="YP_054594.1" /db_xref="EnsemblGenomes-Gn:BSU37360" /db_xref="EnsemblGenomes-Tr:CAE01468" /db_xref="SubtiList:BG14182" /db_xref="UniProtKB/Swiss-Prot:Q7WY57" /translation="MKLPVQQVYSVYGGKDLPKGHSHSTMPFLSKLQFLTKIYLLDIH TQPFFI*" gene 3656653..3656805 /gene="sboX" /locus_tag="BSU_37360" /old_locus_tag="BSU37360" downshifts 3656685 /Source="Nicolas_upshifts" /id="D1934" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="8.85351" /MaxDrop="5.1396" /score="6.03938699" /energy="-13.2" /TU="U2943" /idTUdmin="U2937" /TUdmin=4714 /isTUend="FALSE" promotor_-35 3656800..3656806 /Source="Nicolas_upshift_promotors" /id="U2944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.482517482517482" /psig="0.99000999000999" /xcortree=3233 /SigmaFactorBS="atctacctcttggatatacatacacaaccgtttttcATTTGA AtcatatgtatagggGATGGTATTTTGTTTATAGAgcagatgtttccatttattaatg a" /listShort="albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3656821..3656840 /Source="Nicolas_upshift_promotors" /id="U2944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.482517482517482" /psig="0.99000999000999" /xcortree=3233 /SigmaFactorBS="atctacctcttggatatacatacacaaccgtttttcATTTGA AtcatatgtatagggGATGGTATTTTGTTTATAGAgcagatgtttccatttattaatg a" /listShort="albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3656824 /Source="Nicolas_upshifts" /id="U2944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.482517482517482" /psig="0.99000999000999" /xcortree=3233 /SigmaFactorBS="atctacctcttggatatacatacacaaccgtttttcATTTGA AtcatatgtatagggGATGGTATTTTGTTTATAGAgcagatgtttccatttattaatg a" /listShort="albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" CDS 3656830..3658176 /gene="albA" /locus_tag="BSU_37370" /old_locus_tag="BSU37370" /EC_number="1.21.98.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066831, 15743949, 22366720" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066831, 15743949, 22366720; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subtilosin A thioether formation enzyme" /protein_id="NP_391617.1" /db_xref="EnsemblGenomes-Gn:BSU37370" /db_xref="EnsemblGenomes-Tr:CAB15764" /db_xref="GOA:P71011" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR008792" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017200" /db_xref="InterPro:IPR023885" /db_xref="InterPro:IPR034395" /db_xref="InterPro:IPR034481" /db_xref="SubtiList:BG12471" /db_xref="UniProtKB/Swiss-Prot:P71011" /translation="MFIEQMFPFINESVRVHQLPEGGVLEIDYLRDNVSISDFEYLDL NKTAYELCMRMDGQKTAEQILAEQCAVYDESPEDHKDWYYDMLNMLQNKQVIQLGNRA SRHTITTSGSNEFPMPLHATFELTHRCNLKCAHCYLESSPEALGTVSIEQFKKTADML FDNGVLTCEITGGEIFVHPNANEILDYVCKKFKKVAVLTNGTLMRKESLELLKTYKQK IIVGISLDSVNSEVHDSFRGRKGSFAQTCKTIKLLSDHGIFVRVAMSVFEKNMWEIHD MAQKVRDLGAKAFSYNWVDDFGRGRDIVHPTKDAEQHRKFMEYEQHVIDEFKDLIPII PYERKRAANCGAGWKSIVISPFGEVRPCALFPKEFSLGNIFHDSYESIFNSPLVHKLW QAQAPRFSEHCMKDKCPFSGYCGGCYLKGLNSNKYHRKNICSWAKNEQLEDVVQLI*" gene 3656830..3658176 /gene="albA" /locus_tag="BSU_37370" /old_locus_tag="BSU37370" CDS 3658189..3658350 /gene="albB" /locus_tag="BSU_37380" /old_locus_tag="BSU37380" /function="16.4: Excrete" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809709, 15743949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809709, 15743949; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="membrane component involved in subtilosin production" /protein_id="NP_391618.1" /db_xref="EnsemblGenomes-Gn:BSU37380" /db_xref="EnsemblGenomes-Tr:CAB15765" /db_xref="GOA:P71010" /db_xref="SubtiList:BG12470" /db_xref="UniProtKB/Swiss-Prot:P71010" /translation="MSPAQRRILLYILSFIFVIGAVVYFVKSDYLFTLIFIAIAILFG MRARKADSR*" gene 3658189..3658350 /gene="albB" /locus_tag="BSU_37380" /old_locus_tag="BSU37380" CDS 3658347..3659066 /gene="albC" /locus_tag="BSU_37390" /old_locus_tag="BSU37390" /function="16.5: Explore" /function="16.6: Maintain" /function="16.4: Excrete" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10809709, 15066831, 15743949; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter involved in subtilosin production" /protein_id="NP_391619.1" /db_xref="EnsemblGenomes-Gn:BSU37390" /db_xref="EnsemblGenomes-Tr:CAB15766" /db_xref="GOA:P71009" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12469" /db_xref="UniProtKB/Swiss-Prot:P71009" /translation="MSILDIHDVSVWYERDNVILEQVDLHLEKGAVYGLLGVNGAGKT TLINTLTGVNRNFSGRFTLCGIEAEAGMPQKTSDQLKTHRYFAADYPLLFTEITAKDY VSFVHSLYQKDFSEQQFASLAEAFHFSKYINRRISELSLGNRQKVVLMTGLLLRAPLF ILDEPLVGLDVESIEVFYQKMREYCEAGGTILFSSHLLDVVQRFCDYAAILHNKQIQK VIPIGEETDLRREFFEVIGHE*" gene 3658347..3659066 /gene="albC" /locus_tag="BSU_37390" /old_locus_tag="BSU37390" CDS 3659059..3660369 /gene="albD" /locus_tag="BSU_37400" /old_locus_tag="BSU37400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10809709, 15066831, 15743949, 15849754, 16850406, 18034824; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral membrane protein involved in subtilosinproduction and immunity" /protein_id="NP_391620.1" /db_xref="EnsemblGenomes-Gn:BSU37400" /db_xref="EnsemblGenomes-Tr:CAB15767" /db_xref="GOA:P71008" /db_xref="SubtiList:BG12468" /db_xref="UniProtKB/Swiss-Prot:P71008" /translation="MNNIIPIMSLLFKQLYSRQGKKDAIRIAAGLVILAVFEIGLIRQ AGIDESVLRKTYIILALLLMNTYMVFLSVTSQWKESYMKLSCLLPISSRSFWLAQSVV LFVDTCLRRTLFFFILPLFLFGNGTLSGAQTLFWLGRFSFFTVYSIIFGVVLSNHFVK KKNLMFLLHAAIFACVCISAALMPAATIPLCAVHILWAVVIDFPVFLQAPPQQGKMHS FMRRSEFSFYKREWNRFISSKAMLLNYAVMAVFSGFFSFQMMNTGIFNQQVIYIVISA LLLICSPIALLYSIEKNDRMLLITLPIKRKTMFWAKYRFYSGLLAGGFLLVVMIVGFI SGRSISVLTFLQCIELLLAGAYIRLTADEKRPSFSWQTEQQLWSGFSKYRSYLFCLPL FLAILAGTAVSLAVIPIAGLVIVYYLQKQDGGFFDTSKRERLGS*" gene 3659059..3660369 /gene="albD" /locus_tag="BSU_37400" /old_locus_tag="BSU37400" CDS 3660359..3661519 /gene="albE" /locus_tag="BSU_37410" /old_locus_tag="BSU37410" /function="16.8: Protect" /function="16.5: Explore" /function="16.4: Excrete" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10809709, 15066831, 15743949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidase involved in subtilosin A production" /protein_id="NP_391621.1" /db_xref="EnsemblGenomes-Gn:BSU37410" /db_xref="EnsemblGenomes-Tr:CAB15768" /db_xref="GOA:P71007" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="SubtiList:BG12467" /db_xref="UniProtKB/Swiss-Prot:P71007" /translation="MEVNLLKTHQFSTISIAASFLKPIESAAEPEEETIYFYGAAAYL KEQIIDAFGYAAGSRFMYSANLFFDQQLKTCGTRLIHPLYNGNLHVDALMKTFADLSF PSSLSFEAFEKARNELLLKIEKKFTDPFSYSAARLAEEVFGNPMYGTGMFGRRDRIKA IHPKRFLDATDFIVDLVSQQKQLNILGQVQACDVRGHAPQTSAVTSGRIPVNRHVFET ETRSAAGPSVLTLGFDCGEMKDASDYIKIQLIDGLLGKYGHSALFKHFREKDLAVYHV ITRYDVMNNLLLVSICTDQLHEKDIPPRVLEAVSAFHTDERELEQAKQFLRNELLLQF DSPEGLLAYMGVLRRFSCTKEALLDGISAVTCRDVLQFIATINYIGAHVVRG*" gene 3660359..3661519 /gene="albE" /locus_tag="BSU_37410" /old_locus_tag="BSU37410" CDS 3661524..3662804 /gene="albF" /locus_tag="BSU_37420" /old_locus_tag="BSU37420" /EC_number="3.4.24.-" /function="16.8: Protect" /function="16.4: Excrete" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10809709, 15066831, 15743949, 25817994; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase involved in subtilosin production" /protein_id="NP_391622.1" /db_xref="EnsemblGenomes-Gn:BSU37420" /db_xref="EnsemblGenomes-Tr:CAB15769" /db_xref="GOA:P71006" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG12466" /db_xref="UniProtKB/Swiss-Prot:P71006" /translation="MEKKAFFQQLDERTDIRYTDSGLKIFRLKFPRAHLRLCNVKIDF GSRDVCIRAESGDTLLPYGTAHFLEHLLFWHNGRNLYSDFFAHGALLNAFTTYTDTNF MFTSLPDRLRQTIPILLDALWNHSFDKKIVAQEKAVITSEIQTAHLNHQLSYHYQLIS MLSPSSPAAVFPAGRIEDIEALDISDLQKAYKAAYQAHRMTLFLIGGSENTETLLPPH LQLEKRPDYHAERKIIPACPPVLSQKMMLGDEERMEDTWTGLQIGALPGQNDLLSIKL YWDIAARILFQLDSPFFQEIQQTYRLEIDRLSAETYIYEDGGFLILHSQGTHSSAYID VASYYVTQKKEQVAAWLQYGKDSLTDAIIYDSDYVRKCFEWAAECDRCDCSFLDMYHI IQDMDAQVFLSLIDAMASSNKAIIHVSQKEAIRQ*" gene 3661524..3662804 /gene="albF" /locus_tag="BSU_37420" /old_locus_tag="BSU37420" CDS 3662801..3663502 /gene="albG" /locus_tag="BSU_37430" /old_locus_tag="BSU37430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10809709, 15066831, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein involved in subtilosin production and immunity" /protein_id="NP_391623.1" /db_xref="EnsemblGenomes-Gn:BSU37430" /db_xref="EnsemblGenomes-Tr:CAB15770" /db_xref="GOA:P71005" /db_xref="SubtiList:BG12465" /db_xref="UniProtKB/Swiss-Prot:P71005" /translation="MKQSTVFTLLLLLIGMAAYSFGWVQAVAEAAAQYVQMINNDAVR LGLLACTAALLMLPAFLYLHYVTQSVKNMTAAFQKLTQSHQSCCDFQQHNLCSRYAED VKSLRDSYKNVRQTYVMAAVLCQVIIFGCMFEIVKAVPFRLHTPPAFSMGLAMLLILY LLFCMRTYLRQLFRHGSLFRKVFAGALAAAGIWWMLSFSISELLFLIILAAIQQIGSF IYKRFSYHSTASLDL*" gene 3662801..3663502 /gene="albG" /locus_tag="BSU_37430" /old_locus_tag="BSU37430" downshifts complement(3663069) /Source="Nicolas_upshifts" /id="D1935" /incds=1 /nref=2 /ntot=5 /MaxReadThrough="0.362109999999999" /MaxDrop="3.55474" /score="6.50386958" /energy="-12" /TU="NA" /idTUdmin="U2945" /TUdmin=0 /isTUend="TRUE" S_feature complement(3663158..3663507) /Source="Nicolas_S_feature" /locus_tag="new_3842651_3843000_c" /HighExp="BT, B36, B60, Pyr, G/S, Mal, S3, G135, M/G, Sw" /AntisenseName="albG" /AntisenseCor="2.0087959212361201E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1449" downshifts complement(3663201) /Source="Nicolas_upshifts" /id="D1936" /incds=1 /nref=6 /ntot=18 /MaxReadThrough="3.01883" /MaxDrop="4.2137" /score="6.50386958" /energy="-12" /TU="U2945" /idTUdmin="U2945" /TUdmin="-132" /isTUend="FALSE" S_feature 3663503..3665985 /Source="Nicolas_S_feature" /locus_tag="new_3842996_3845478" /HighExp="Lbstat, nit, ferm, BI, M0t90, S2, M40t90, BT, M0t45, GM 150" /AntisenseName="ywhL" /AntisenseCor="7.7827453562424306E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.99, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1450" CDS complement(3663508..3664884) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12073041" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391624.1" /db_xref="EnsemblGenomes-Gn:BSU37440" /db_xref="EnsemblGenomes-Tr:CAB15771" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12464" /db_xref="UniProtKB/Swiss-Prot:P71004" /translation="MKKNDLSALQENCFCFCDEEISREAPFQVPIDFPEGFKVDTAEA SAAVTWSTDNLSCISEPCLIQTGPEPEDIGVRYAVRVQGTITLLVSVSPVRNQYGQGD GAVSVIHTEEIDQVVYYAAQSGRCPDFSQITVEDLLIVPPFYGSPLTVAGTLVLPPSP DPQSYVFTANTGDSTVSVIDADLNTVVKTIPFSDVPTNLGVTFDKAFTYVLHGNTNLV SVIDNKTLTIINTITVGGGPRKIEFDPTDEFAYVMAAGSIYVINTASQSVIDVIPIPG ALDFALDPNGQYVYTANGSSWSVDKYDVNTGQLVESIIDTFEFPSLITTPYAGNFAYV LNGELWPKGVTEISLSPLSRGGDFSRLFETLRTIVFSLDSTRAYFLEPYSEPFLINNL YVVNTARQRIIANVSLPGAFDLAVTPDKQYIYAAQPNDNAVTVYRTSDYTAVTVIPVG AGPSAIAM*" gene complement(3663508..3664884) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" CDS complement(3664923..3666278) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12073041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073041; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DNA helicase PcrA" /protein_id="NP_391625.1" /db_xref="EnsemblGenomes-Gn:BSU37450" /db_xref="EnsemblGenomes-Tr:CAB15772" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12463" /db_xref="UniProtKB/Swiss-Prot:P71003" /translation="MRKNKLSFKEKAGAEQEECLCFCEGEASREAMFQAPIELPEGFV VDPAEAVANVTWNADSLSCVSDRCLIQTGPEPDEVGVQFAVRLQGTVTLLVSVSPVRN QYGQGDGAVSVIHNAEIDQVVYYSDESDDCPDISDITIENLVVVPPFYGSPLSVTGTI VLVPEPEPVYAFTANPNDQSVSVIDTNTDTVVTTIALPYNPAGIEITPDKSAVFVLHP NNNVISVIDYDTLTVTATILLDQPPRLIRFIPNHEFAYVFTGTAVYVIGIDTLTVDRS IPVEGYDVAIDPNGLFAYVLNFGIVQKVDLTTGEVTGTIERELIVSTIETNWPERYAY VLEQEFFFNYLTVIDLNTFTISSTQELEYEGEYRMFTSGAEVYLYDGFTGNLYSVSPN GAGVIGNVPQSATDYAFTPNGDFLYATRFIEQSIIVYNTDDYSEETVISLGVSPGAIT I*" gene complement(3664923..3666278) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" promotor_-10 complement(3666314..3666333) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3666332) /Source="Nicolas_upshifts" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" promotor_-35 complement(3666346..3666355) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3666458..3666477 /Source="Nicolas_upshift_promotors" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3666459 /Source="Nicolas_upshifts" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" downshifts complement(3666504) /Source="Nicolas_upshifts" /id="D1937" /incds=0 /nref=7 /ntot=59 /MaxReadThrough="2.35357" /MaxDrop="4.85842" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=1867 /isTUend="FALSE" CDS 3666508..3667653 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase anti-activator of ComA" /protein_id="NP_391626.1" /db_xref="EnsemblGenomes-Gn:BSU37460" /db_xref="EnsemblGenomes-Tr:CAB15773" /db_xref="GOA:P71002" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:3ULQ" /db_xref="PDB:4I9C" /db_xref="PDB:4I9E" /db_xref="SubtiList:BG11968" /db_xref="UniProtKB/Swiss-Prot:P71002" /translation="MTGVISSSSIGEKINEWYMYIRRFSIPDAEYLRREIKQELDQME EDQDLHLYYSLMEFRHNLMLEYLEPLEKMRIEEQPRLSDLLLEIDKKQARLTGLLEYY FNFFRGMYELDQREYLSAIKFFKKAESKLIFVKDRIEKAEFFFKMSESYYYMKQTYFS MDYARQAYEIYKEHEAYNIRLLQCHSLFATNFLDLKQYEDAISHFQKAYSMAEAEKQP QLMGRTLYNIGLCKNSQSQYEDAIPYFKRAIAVFEESNILPSLPQAYFLITQIHYKLG KIDKAHEYHSKGMAYSQKAGDVIYLSEFEFLKSLYLSGPDEEAIQGFFDFLESKMLYA DLEDFAIDVAKYYHERKNFQKASAYFLKVEQVRQLIQGGVSLYEIEV*" gene 3666508..3667653 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" promotor_-35 3667512..3667516 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3667533..3667552 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3667540 /Source="Nicolas_upshifts" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" downshifts complement(3667623) /Source="Nicolas_upshifts" /id="D1938" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="1.70728" /MaxDrop="2.74755" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=748 /isTUend="FALSE" CDS 3667637..3667756 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type f: factor" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapF" /protein_id="NP_391627.1" /db_xref="EnsemblGenomes-Gn:BSU37470" /db_xref="EnsemblGenomes-Tr:CAB15774" /db_xref="GOA:P71001" /db_xref="InterPro:IPR025899" /db_xref="SubtiList:BG11960" /db_xref="UniProtKB/Swiss-Prot:P71001" /translation="MKLKSKLLLSCLALSTVFVATTIANAPTHQIEVAQRGMI*" gene 3667637..3667756 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" downshifts 3667741 /Source="Nicolas_upshifts" /id="D1939" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="5.48985" /MaxDrop="6.14096" /score="19.6493244" /energy="-9.9" /TU="U2946" /idTUdmin="U2947" /TUdmin="-4" /isTUend="TRUE" S_feature 3667786..3667854 /Source="Nicolas_S_feature" /locus_tag="new_3847279_3847347" /HighExp="S2, S3, S4, S5, S6, S1, BT, S7, S8, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.921" /TUlongSig="NA" /TUlongPSig="NA" /label="S1451" CDS 3667855..3668328 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA editing enzyme" /protein_id="NP_391628.1" /db_xref="EnsemblGenomes-Gn:BSU37480" /db_xref="EnsemblGenomes-Tr:CAB15775" /db_xref="GOA:P71000" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12462" /db_xref="UniProtKB/Swiss-Prot:P71000" /translation="MSLKSVRTHFTQWNRENDVTEFETSSATVEQAAETIGVSLSRIA KSLSFRGEGDQVILIVAAGDAKIDNKKSRQTFGFKARMLSPNEVLEQTGHEIGGVCPF GLAHDPEVYLDVSLKRFQTVFPACGSRNSAIELTPKELSEFSFSKVWIDVCKDWE*" gene 3667855..3668328 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" downshifts 3668317 /Source="Nicolas_upshifts" /id="D1940" /incds=0 /nref=30 /ntot=156 /MaxReadThrough="2.85314" /MaxDrop="4.40065" /score="-6.80415499" /energy="-11.3" /TU="NA" /idTUdmin="U2946" /TUdmin=0 /isTUend="TRUE" CDS complement(3668360..3669232) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" /EC_number="3.5.3.11" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9723923, 10931887, 24678831, 28807600, 28291380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10931887, 24678831, 28807600, 28291380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="agmatinase" /protein_id="NP_391629.1" /db_xref="EnsemblGenomes-Gn:BSU37490" /db_xref="EnsemblGenomes-Tr:CAB15776" /db_xref="GOA:P70999" /db_xref="InterPro:IPR005925" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG12461" /db_xref="UniProtKB/Swiss-Prot:P70999" /translation="MRFDEAYSGKVFIASRPEWEEADAILYGMPMDWTVSYRPGSRFG PSRIREVSIGLEEYSPYLDRDLADLNFFDAGDIPLPFGNPQRSLDMIEEYVDSILEKG KFPMGMGGEHLVSWPVIKAMYKKYPDLAIIHFDAHTDLRVDYEGEPLSHSTPIRKAAE LIGPHNVYSFGIRSGMKEEFEWAKENGMHISKFEVLEPLKEVLPKLAGRPVYVTIDID VLDPAHAPGTGTVDAGGITSKELLASVHEIARSEVNVKGADLVEVAPVYDHSEQTANT ASKIIREMLLGFVK*" gene complement(3668360..3669232) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" downshifts complement(3668371) /Source="Nicolas_upshifts" /id="D1941" /incds=0 /nref=49 /ntot=171 /MaxReadThrough="2.5482" /MaxDrop="5.46925" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=0 /isTUend="TRUE" downshifts complement(3668437) /Source="Nicolas_upshifts" /id="D1942" /incds=1 /nref=8 /ntot=50 /MaxReadThrough="5.83631" /MaxDrop="3.87062" /score="29.5788849" /energy="-11.3" /TU="U2948" /idTUdmin="U2948" /TUdmin="-66" /isTUend="FALSE" CDS complement(3669293..3670123) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" /EC_number="2.5.1.16" /function="16.3: Control" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9723923, 26735940, 28546427, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 26735940, 28546427, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spermidine synthase; polyamine metabolism" /protein_id="NP_391630.1" /db_xref="EnsemblGenomes-Gn:BSU37500" /db_xref="EnsemblGenomes-Tr:CAB15777" /db_xref="GOA:P70998" /db_xref="InterPro:IPR001045" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030373" /db_xref="InterPro:IPR030374" /db_xref="InterPro:IPR035246" /db_xref="InterPro:IPR037163" /db_xref="PDB:1IY9" /db_xref="SubtiList:BG12460" /db_xref="UniProtKB/Swiss-Prot:P70998" /translation="MSELWYTEKQTKNFGITMKVNKTLHTEQTEFQHLEMVETEEFGN MLFLDGMVMTSEKDEFVYHEMVAHVPLFTHPNPEHVLVVGGGDGGVIREILKHPSVKK ATLVDIDGKVIEYSKKFLPSIAGKLDDPRVDVQVDDGFMHIAKSENQYDVIMVDSTEP VGPAVNLFTKGFYAGIAKALKEDGIFVAQTDNPWFTPELITNVQRDVKEIFPITKLYT ANIPTYPSGLWTFTIGSKKYDPLAVEDSRFFDIETKYYTKDIHKAAFVLPKFVSDLIK *" gene complement(3669293..3670123) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" S_feature complement(3670124..3670219) /Source="Nicolas_S_feature" /locus_tag="new_3849617_3849712_c" /HighExp="Paraq, G180, Oxctl, H2O2, LBGexp, G150, G135, C30, dia15, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1452" promotor_-10 complement(3670207..3670226) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3670218) /Source="Nicolas_upshifts" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" promotor_-35 complement(3670239..3670246) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3670264..3670269 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3670285..3670303 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3670287 /Source="Nicolas_upshifts" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" CDS 3670325..3672400 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10767540, 11567005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10767540, 11567005; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation specific penicillin-binding protein 2D" /protein_id="NP_391631.2" /db_xref="EnsemblGenomes-Gn:BSU37510" /db_xref="EnsemblGenomes-Tr:CAB15778" /db_xref="GOA:P70997" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG12459" /db_xref="UniProtKB/Swiss-Prot:P70997" /translation="MDAMTNKRLRLTLKTVRAFIFLGAFAALAAAAVFMTVILIAKYQ GAPSVQVPQSTILYASDGSKLGETNYGEKRYWVPLKDMNPTIVKATVAIEDQNFYDHH GFDYKRMAGAALADLKAFAKVQGASTITQQYARNLYLEHDKTWKRKWNEAFYTIRLEQ NYSKDEILEGYLNTIYYGHGAYGIEAASRLYFGKHAKNLTDAEAALLAGIPKGPSGYS PYVNETKAKERQKTIVRMMEKQQMISQKKADELIKEPLSYQPLNKQVSKRKAPYFYDN AMRELEKKLGMTREQIETSGLNVYTTVDKRMQRIAEETITETVNAGSDIQVGFSAIDP RTGNVLALVGGRDYQKSPFDRTTQAKRQPASTIKPLLYYKAIQSGFTPVTLMKSEETE FQIDAKGETYSPSNYNGYYANKPITLLQALALSDNIYAVKTHLFLGTNKLVKTAKEFG ITAHLQALPSLALGTEPVRPIEMVNAYAMLANGGKKIEPTFISRVTDAAGHVLYENPN QHKQVLDEKAAFVTASMMTGMFDIDLNGYTSVTGRTIANRLTRTYAGKSGTTSADSWM IGFNPKLAAGVWTGYDKNSTIDSVEEKSYAKTIWADFMEDALKGEPETAFKPPKGVTG VYIDPETGYSSGPGCAAKHYTYFVKGTEPANVCYGAEPAKQTKDRLPSKEKPASEKKW WDKWLGRHH*" gene 3670325..3672400 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" downshifts complement(3672453) /Source="Nicolas_upshifts" /id="D1943" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="1.43573" /MaxDrop="3.61075" /score="-7.59753556" /energy="-10.7" /TU="NA" /idTUdmin="U2951" /TUdmin="-11" /isTUend="TRUE" S_feature complement(3672577..3672692) /Source="Nicolas_S_feature" /locus_tag="new_3852070_3852185_c" /HighExp="Sw, C90, BI, dia5, dia15, Diami, LBGexp, M0t45, Lbexp, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1453" downshifts complement(3672620) /Source="Nicolas_upshifts" /id="D1944" /incds=0 /nref=198 /ntot=248 /MaxReadThrough="3.25498" /MaxDrop="6.4287" /score="-7.59753556" /energy="-10.7" /TU="U2951,U2952" /idTUdmin="U2952" /TUdmin="-156" /isTUend="FALSE" CDS complement(3672693..3673211) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391632.1" /db_xref="EnsemblGenomes-Gn:BSU37520" /db_xref="EnsemblGenomes-Tr:CAB15779" /db_xref="InterPro:IPR014852" /db_xref="SubtiList:BG12458" /db_xref="UniProtKB/Swiss-Prot:P70996" /translation="MEEKKKKSIGFNIIKSDPTDGHGGFGVGALSLDNISPVFVDVEE KEAFVDIGAMHARSTVEKGIKFLPNKEEVPNGKPYWLVWVTIDRKEEGPYYAGVTACE MTVDRSIRRGYKSLPEHVNLMDKSMKRKIIVDKMDDSSKRVLGEFLKKHDQGLWDRSS DELKTSLLPENN*" gene complement(3672693..3673211) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" CDS complement(3673225..3673884) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" /EC_number="3.4.24.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25649915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase; integral membrane protein" /protein_id="NP_391633.1" /db_xref="EnsemblGenomes-Gn:BSU37530" /db_xref="EnsemblGenomes-Tr:CAB15780" /db_xref="GOA:P70995" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG12457" /db_xref="UniProtKB/Swiss-Prot:P70995" /translation="MDRFLYYPLSLMPYLVITLIVSFTMHELAHAYVAYKFGDDTAKK QGRLTLNPIKHLDPFGTILILVAGFGWARPIPVNRRFFKKPRLAGVLVSIAGPVSNLI LAFIGFFLLVLMHAYGMEMLAAFSTGLDQFFSIWIQLNLVLFLFNLLPLPPLDGYRII EDLVPPGVRAKMTQAESYGFIVFLVLFVTPLGSYVLWPMLNAGRDSILKLFSAIFQPL L*" gene complement(3673225..3673884) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" promotor_-35 3673907..3673910 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3673920..3673939) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 3673925..3673944 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3673928 /Source="Nicolas_upshifts" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" upshifts complement(3673938) /Source="Nicolas_upshifts" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" S_feature complement(3673940..3674223) /Source="Nicolas_S_feature" /locus_tag="new_3853433_3853716_c" /HighExp="Diami, dia5, dia15, C90, Etha, Sw, H2O2, G135, M40t45, Lbtran" /AntisenseName="ywhB" /AntisenseCor="0.10541372702249199" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1454" promotor_-35 complement(3673954..3673961) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3673993..3674181 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" /EC_number="5.3.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12051677, 14624569, 14730980, 15301547, 17902707" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12051677, 14624569, 14730980, 15301547, 17902707; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxymuconate tautomerase (promiscuous)" /protein_id="NP_391634.1" /db_xref="EnsemblGenomes-Gn:BSU37540" /db_xref="EnsemblGenomes-Tr:CAB15781" /db_xref="GOA:P70994" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="InterPro:IPR018191" /db_xref="PDB:2OP8" /db_xref="PDB:2OPA" /db_xref="SubtiList:BG12456" /db_xref="UniProtKB/Swiss-Prot:P70994" /translation="MPYVTVKMLEGRTDEQKRNLVEKVTEAVKETTGASEEKIVVFIE EMRKDHYAVAGKRLSDME*" gene 3673993..3674181 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" downshifts 3674170 /Source="Nicolas_upshifts" /id="D1945" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="1.74275" /MaxDrop="4.93207" /score="4.21502693" /energy="-10.5" /TU="NA" /idTUdmin="U2950" /TUdmin=0 /isTUend="TRUE" CDS complement(3674224..3674643) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391635.1" /db_xref="EnsemblGenomes-Gn:BSU37550" /db_xref="EnsemblGenomes-Tr:CAB15782" /db_xref="GOA:P70993" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12455" /db_xref="UniProtKB/Swiss-Prot:P70993" /translation="MDHDKLEANLLDHALTKYLKSTKQLDEATVPKHVNNVRGFILRI IYRHGSCTIKDILKEVTLSPSATTTALNHLEQEGFIERSRNNNDRRTVWITLSESGRG AAEQMIENRQQLIDGMFERLTAEEKKTFLAIIAKLAQ*" gene complement(3674224..3674643) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" promotor_-10 complement(3674693..3674712) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3674704) /Source="Nicolas_upshifts" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" promotor_-35 complement(3674727..3674734) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3674763..3676679) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9353933, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9353933, 15831787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_391636.2" /db_xref="EnsemblGenomes-Gn:BSU37560" /db_xref="EnsemblGenomes-Tr:CAB15783" /db_xref="GOA:P18256" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10421" /db_xref="UniProtKB/Swiss-Prot:P18256" /translation="MSKHVHIQLPDGQIQEYPKGITIKEAAGSISSSLQKKAAAGQVN GKLVDLSFKLEEDAELSIVTLDSQEGLQVLRHTTAHVLAQAVKRLYGEVSLGVGPVIL DGFYYDMKLGKSLASGDLEAIEKEMKNIINENLEIKRIEVSYEEAEELFAQKDERLKL EILKDIPRGEDITLYQQGEFVDLCRGPHLPSTGMIKAFKLTRVSGAYWRGDSKNEVLQ RVYGVAFQKKKDLDAHLHMLEEAAKRDHRKLGKQLGLFMFSEEAPGMPFYLPKGQIVR NELERFSRELQTNAGYDEVRTPFMMNQRLWEQSGHWDHYRDNMYFSEVDDTRFAMKPM NCPGHMLIFKNSLYSYRDLPIRMAEFGQVHRHEYSGALNGMLRVRTFCQDDAHIFVRE DQIESEIKEAIRLIDEVYRTFGFEYSVELSTRPEDSLGDDSLWEASERALARVLEELG LSYEINEGDGAFYGPKIDFHIKDALKRSHQCATIQLDFQMPEKFDLTYINELNEKVRP VVIHRAVFGSIDRFFGILIEHYGGAFPVWLAPIQVQIIPVSHVHLDYCRKVQAELKQA GIRAGIDERNEKLGYKIRESQVQKIPYVLVLGDHEEQENAVNVRRFGHQQNEHVPFQT FKDKLVKQVENRGM*" gene complement(3674763..3676679) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" promotor_-10 complement(3675957..3675975) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3675962) /Source="Nicolas_upshifts" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3675992..3675996) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3676710) /Source="Nicolas_upshifts" /id="D1946" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.2774" /MaxDrop="3.56231" /score="36.3785359" /energy="-19.5" /TU="U2955" /idTUdmin="U2953" /TUdmin="-968" /isTUend="FALSE" misc_RNA complement(3676733..3676954) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" /product="T-box" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" gene complement(3676733..3676954) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" misc_RNA complement(3676986..3677207) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" gene complement(3676986..3677207) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" S_feature complement(3677239..3677501) /Source="Nicolas_S_feature" /locus_tag="new_3856732_3856994_c" /HighExp="S8, S7, S6, S5, BT, Sw, B36, B60, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.61719100000000005" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1455" downshifts 3677250 /Source="Nicolas_upshifts" /id="D1947" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="0.92811" /MaxDrop="3.85666" /score="1.17237511" /energy="-8.3" /TU="NA" /idTUdmin="U2950" /TUdmin=3080 /isTUend="FALSE" downshifts complement(3677282) /Source="Nicolas_upshifts" /id="D1948" /incds=0 /nref=52 /ntot=200 /MaxReadThrough="6.68945" /MaxDrop="6.6969" /score="36.414771" /energy="-17.3" /TU="U2955" /idTUdmin="U2953" /TUdmin="-1540" /isTUend="FALSE" CDS complement(3677289..3677444) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514011.1" /translation="MLFTVSREGRTAEIFLTQGKQLTAFEPYQGKQVSDTVMLRYSIF KPIIMCN*" gene complement(3677289..3677444) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" promotor_-35 3677451..3677454 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3677463..3677476 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3677470 /Source="Nicolas_upshifts" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3677478..3677497) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3677501) /Source="Nicolas_upshifts" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" promotor_-35 complement(3677511..3677517) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3677524..3678924) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11104814, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11104814, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="toxic compound efflux transporter (may export homoserine)" /protein_id="NP_391637.1" /db_xref="EnsemblGenomes-Gn:BSU37570" /db_xref="EnsemblGenomes-Tr:CAB15784" /db_xref="GOA:Q00538" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10420" /db_xref="UniProtKB/Swiss-Prot:Q00538" /translation="MKNSGSIQESTSSTGISVLIVLALGFLMATLDVTVVNVAMADMK NTLSMSLSGVTWVVDGYILTFASLLLAGGALADRFGSKTIYILGLAVFVMASCLCAAS INGQMLIAGRLIQGIGAALFMPSSLSLLAASYLDERARARMFGLWAALVSAASALGPF IGGVLVQLAGWQSIFLINVPIGAAALISAYRILSRVPGKSSRVNIIGHLLGMMALGFL SYALIQGPSAGWRSPVILVAFTAAVLAFVLFLLREISAKTPILPASLYKNGRFSAAQF IGFLLNFALFGGMFMLSLFLQEAGGASSFMAGVELLPMMAVFVIGNLLFARLANRFEA GQLMFVSMAVSCIIALLLFVLISPDFPYWQLAVLMSVMNLCTGITVPAMTTVIMQAAG QRHTNIAGAALNANRQIGALVGVAITGVIIHLSATWYAGAGFAFLMMGAAYSLAALLV WLFLAAHNGTAASEKM*" gene complement(3677524..3678924) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" CDS complement(3678924..3679394) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885456; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391638.1" /db_xref="EnsemblGenomes-Gn:BSU37580" /db_xref="EnsemblGenomes-Tr:CAB15785" /db_xref="GOA:P71047" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12454" /db_xref="UniProtKB/Swiss-Prot:P71047" /translation="MKMKSGMEQAVSVLLLLSRLPVQASLTSEAISQRLRVSPSYLKK LMRTLVQAGLAESLPGTKGGFTLTKPLADITLYDVYQAVEGRGSMYQGKGLLQSVFEG ESHCVLETVMAEIEDKWSNLMREESLQHVMDRVGELYDLEKIDDWVIKQVKGQL*" gene complement(3678924..3679394) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" downshifts complement(3679350) /Source="Nicolas_upshifts" /id="D1949" /incds=0 /nref=11 /ntot=145 /MaxReadThrough="2.78131" /MaxDrop="4.29115" /score="17.3758052" /energy="-11.2" /TU="NA" /idTUdmin="U2956" /TUdmin=0 /isTUend="TRUE" CDS complement(3679506..3680006) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391639.1" /db_xref="EnsemblGenomes-Gn:BSU37590" /db_xref="EnsemblGenomes-Tr:CAB15786" /db_xref="SubtiList:BG12453" /db_xref="UniProtKB/Swiss-Prot:P71046" /translation="MLKEHAKLMKVFSDSGEIIGRKKLQKMIYIAKKMQFPFYEKYDF HFYGPYSEELTLQIEELCNLGFLHEVKEKKGGYFQYRYSLTETGSAFLDHADLDMPDM KGYIDSVNSRSSRFLELVSTILYFDGLEDEEKKEKVFTIKSKQKYTNEEYDEALQYIE ELKQIC*" gene complement(3679506..3680006) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" downshifts complement(3679509) /Source="Nicolas_upshifts" /id="D1950" /incds=0 /nref=9 /ntot=105 /MaxReadThrough="4.00805" /MaxDrop="6.12059" /score="17.3758052" /energy="-11.2" /TU="U2956,U2957" /idTUdmin="U2957" /TUdmin="-137" /isTUend="FALSE" CDS complement(3680042..3681343) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent nucleotide (pyro)phosphohydrolase" /protein_id="NP_391640.1" /db_xref="EnsemblGenomes-Gn:BSU37600" /db_xref="EnsemblGenomes-Tr:CAB15787" /db_xref="GOA:P39651" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG10639" /db_xref="UniProtKB/Swiss-Prot:P39651" /translation="MAYPNGKLSEEKVFKDPVHRYVHVRDKLIWDLIGTREFQRLRRI KQLGTTYLTFHGAEHSRFNHSLGVYEIVRRMVDDVFKGRPEWDDSERELCLAAALLHD LGHGPFSHSFEKVFHLDHEDFTRGIILGDTEVNQVLRKVSPGFPQDVAEVIAKTYKNK QVVSLISSQIDADRMDYLQRDAYYTGVSYGHFDMERILRVMRPREDQIVIKESGMHAV EDYIMSRYQMYWQVYFHPVTRSAEVILTKILHRAKQLHDEGYVFTHAPVHFYSIFEGK LTLEDYVKLDESIILYYFQAWEDEEDAILSDLCRRFINRQLFQYVEFNPNEEMSAYFE LTSLFKEAGIDPSYYLVVDSSSDLPYDFYRPGEEEERLPIHLLTQNGQIKELSRQSAI VESISGKRRTDHKLYYPKDLICDGTKHPEAKMKIRQLLGLT*" gene complement(3680042..3681343) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" promotor_-10 complement(3681367..3681386) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3681381) /Source="Nicolas_upshifts" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" S_feature complement(3681383..3681504) /Source="Nicolas_S_feature" /locus_tag="new_3860876_3860997_c" /HighExp="G180, Paraq, Oxctl, G135, H2O2, G150, C30, LBGstat, LBGexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1456" promotor_-35 complement(3681402..3681404) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3681505..3681729) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391641.1" /db_xref="EnsemblGenomes-Gn:BSU37610" /db_xref="EnsemblGenomes-Tr:CAB15788" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR020880" /db_xref="SubtiList:BG14164" /db_xref="UniProtKB/Swiss-Prot:O32280" /translation="MANEFRVCDDCQATNIKTLLPRLKEVDPDAKVEVGCQSYCGPGR KKSFAFVNNRPLSAPTEDELIDKVKKKIKK*" gene complement(3681505..3681729) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" S_feature complement(3681730..3681814) /Source="Nicolas_S_feature" /locus_tag="new_3861223_3861307_c" /HighExp="G180, Paraq, H2O2, G135, LBGexp, dia15, G150, Lbexp, Heat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1457" promotor_-10 complement(3681803..3681822) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3681813) /Source="Nicolas_upshifts" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" promotor_-35 complement(3681837..3681840) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3681880..3681886 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3681901..3681912 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3681902 /Source="Nicolas_upshifts" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" CDS 3681944..3682720 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10629188, 16497325, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629188, 16497325, 22829778; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="prespore-specific transcription regulatory gene" /protein_id="NP_391642.1" /db_xref="EnsemblGenomes-Gn:BSU37620" /db_xref="EnsemblGenomes-Tr:CAB15789" /db_xref="GOA:P39650" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017877" /db_xref="SubtiList:BG10638" /db_xref="UniProtKB/Swiss-Prot:P39650" /translation="MTKQRQDAWSEENDLLLAETVLRHVREGSTQLNAFEEVGDKLNR TSAACGFRWNAVVRHQYEKALQLAKKQRKQRMRALGNGQPAKKRLLYQPPAVDPEIIQ ETAAEEPVKTETPSVENEQPLMSGEHMPFVDESFKEELASLSHLLSPQTPAAAPEMTM NDVIRFLQNYEGNHEQSSALKMENERLKKENQELQNKTEQLEAEVQKLEKDQKTIQED YETLVKIMNRARKLVLFEEDEHASPSFKMDRNGNLEKLAE*" gene 3681944..3682720 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" downshifts 3682706 /Source="Nicolas_upshifts" /id="D1951" /incds=0 /nref=14 /ntot=78 /MaxReadThrough="4.08166" /MaxDrop="4.36214" /score="-5.88286948" /energy="-14.4" /TU="U2958" /idTUdmin="U2958" /TUdmin="-3036" /isTUend="FALSE" promotor_-35 3682808..3682815 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3682830..3682849 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3682834..3687060 /Source="Nicolas_S_feature" /locus_tag="new_3862327_3866553" /HighExp="T1.30H, T2.0H, T1.0H, T2.30H, T0.30H, T3.0H, T3.30H, T4.0H, T5.0H, T0.0H" /AntisenseName="pta" /AntisenseCor="-0.61235087907102503" /AntisenseRegPval="-28.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.836" /TUlongSig="NA" /TUlongPSig="NA" /label="S1458" upshifts 3682834 /Source="Nicolas_upshifts" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" CDS complement(3682864..3683754) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative toxic excess metabolite exporter" /protein_id="NP_391643.1" /db_xref="EnsemblGenomes-Gn:BSU37630" /db_xref="EnsemblGenomes-Tr:CAB15790" /db_xref="GOA:P39649" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004779" /db_xref="SubtiList:BG10637" /db_xref="UniProtKB/Swiss-Prot:P39649" /translation="MKGNIYSLFVLIAAFFWGTTGTVQALAPESATPLAFGAFRLLIG GSAMLLAVWISRELHVKNWAWPLVFLAAVCMACYQPLFFTAVKETGIAVGTVIAIGSA PIIAGTLEWAVLKKRPRNSWWIATVLALAGCWLLFSDSSNVRIDVAGVLMALGAGASF AGYTLISKAMMKTQPPRATSAVVFMISAILLTPLLWQLDISWILTPRGLGTSLYIGLI ATCAAYFLFAKGLTGVPASAAVTLSLAEPLTASLLGVFFIGEMLSPSSWLGIALMMLG LLVISAAPRKQKTAEAAHMS*" gene complement(3682864..3683754) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" promotor_no_box complement(3683754..3683854) /Source="Nicolas_upshift_promotors" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3683794) /Source="Nicolas_upshifts" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" CDS complement(3683922..3684767) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" /function="4: Biosynthesis of cofactors, prosthetic groups, and carriers" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidotransferase of the octanoyl moiety from octanoyl-GcvH to the E2 subunit of pyruvate dehydrogenase" /protein_id="NP_391644.1" /db_xref="EnsemblGenomes-Gn:BSU37640" /db_xref="EnsemblGenomes-Tr:CAB15791" /db_xref="GOA:P39648" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024897" /db_xref="SubtiList:BG10636" /db_xref="UniProtKB/Swiss-Prot:P39648" /translation="MANQPIDLLMQPKWRVIDQSSLGPLFDAKQSFAMDDTLCMSVGK GVSPATARSWVHHDTIVLGIQDTRLPFLQDGISLLESEGYRVIVRNSGGLAVVLDDGV LNISLIFEDEKKGIDIDKGYEAMVELMRRMLRPYNAKIEAYEIEGSYCPGSYDLSING KKFAGISQRRVRGGVAVQIYLCADKSGSERADLIRRFYQAALKDKQNDKKGVYPEIRP ETMASLSELLQKDISVQDLMFALLTELKALSTHLYSAGLSIDEEMEFEKNLVRMAERN AKVFG*" gene complement(3683922..3684767) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" downshifts complement(3684085) /Source="Nicolas_upshifts" /id="D1952" /incds=1 /nref=4 /ntot=180 /MaxReadThrough="3.21908" /MaxDrop="3.30122" /score="31.9003746" /energy="-18.6" /TU="U2961" /idTUdmin="U2961" /TUdmin="-27" /isTUend="FALSE" CDS complement(3684816..3685715) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sulfur assimilation CysL, activatescysJI expression" /protein_id="NP_391645.1" /db_xref="EnsemblGenomes-Gn:BSU37650" /db_xref="EnsemblGenomes-Tr:CAB15792" /db_xref="GOA:P39647" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10635" /db_xref="UniProtKB/Swiss-Prot:P39647" /translation="MYYDVLKTFIAVVEEKNFTKAAEKLMISQPSVSLHIKNLEKEFQ TALLNRSPKHFTTTPTGDILYQRAKQMVFLYEQAKAEIYAHHHYVKGELKIAASFTIG EYILPPLLAQLQKLYPELNLDVMIGNTEEVSERVRMLQADIGLIEGHTNENELEIEPF MEDEMCIAAPNQHPLAGRKEISISDLQNEAWVTREKGSGTREYLDHVLSSNGLRPKSM FTISSNQGVKEAVINGMGLSVLSRSVLRKDLIHREISILHINNFSLKRKLSYIHSPLM ENTKNKEIFITMLKSNYQSQLLK*" gene complement(3684816..3685715) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" promotor_-10 complement(3685758..3685777) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3685761) /Source="Nicolas_upshifts" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" promotor_-35 complement(3685791..3685798) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3685862) /Source="Nicolas_upshifts" /id="D1953" /incds=0 /nref=222 /ntot=251 /MaxReadThrough="1.96406" /MaxDrop="7.24606" /score="32.3178773" /energy="-17.3" /TU="NA" /idTUdmin="U2962" /TUdmin=0 /isTUend="TRUE" CDS complement(3685862..3686833) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" /EC_number="2.3.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphotransacetylase" /protein_id="NP_391646.1" /db_xref="EnsemblGenomes-Gn:BSU37660" /db_xref="EnsemblGenomes-Tr:CAB15793" /db_xref="GOA:P39646" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR004614" /db_xref="InterPro:IPR012147" /db_xref="PDB:1TD9" /db_xref="PDB:1XCO" /db_xref="SubtiList:BG10634" /db_xref="UniProtKB/Swiss-Prot:P39646" /translation="MADLFSTVQEKVAGKDVKIVFPEGLDERILEAVSKLAGNKVLNP IVIGNENEIQAKAKELNLTLGGVKIYDPHTYEGMEDLVQAFVERRKGKATEEQARKAL LDENYFGTMLVYKGLADGLVSGAAHSTADTVRPALQIIKTKEGVKKTSGVFIMARGEE QYVFADCAINIAPDSQDLAEIAIESANTAKMFDIEPRVAMLSFSTKGSAKSDETEKVA DAVKIAKEKAPELTLDGEFQFDAAFVPSVAEKKAPDSEIKGDANVFVFPSLEAGNIGY KIAQRLGNFEAVGPILQGLNMPVNDLSRGCNAEDVYNLALITAAQAL*" gene complement(3685862..3686833) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" promotor_-10 complement(3686868..3686887) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3686893) /Source="Nicolas_upshifts" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" promotor_-35 complement(3686903..3686907) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3686981..3686992) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3686984) /Source="Nicolas_upshifts" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" promotor_-35 complement(3687006..3687012) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3687055..3687074 /Source="Nicolas_upshift_promotors" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3687062 /Source="Nicolas_upshifts" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" CDS 3687103..3687867 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" /EC_number="4.1.-.-" /function="4.3: Heme, porphyrin, and cobalamin" /experiment="publication(s) with functional evidences, PMID:15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-coproporphyrin (coproheme) decarboxylase" /protein_id="NP_391647.3" /db_xref="EnsemblGenomes-Gn:BSU37670" /db_xref="EnsemblGenomes-Tr:CAB15794" /db_xref="GOA:P39645" /db_xref="InterPro:IPR010644" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR031332" /db_xref="SubtiList:BG10633" /db_xref="UniProtKB/Swiss-Prot:P39645" /translation="MSEQQMTNEAAKTLDGWYALHDFRTMDWASWKLLSSDERQSIIH EFTGLLEKWGVAQKEGKGSQTLYSIVGQKADFMLMILRPTMEELNQIELEFNKSRLAE FTIPAYSYVSVVELSNYLASGDGDPYENPHVRARLYPELPESKYVCFYPMDKRRSGND NWYMLSMEERRNLMRSHGLIGRSYAGKVKQIITGSVGFDDYEWGVTLFSDDVLQFKKL VYEMRFDEVSARYGEFGSFFVGNHLSLDTLPQFLYV*" gene 3687103..3687867 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" downshifts 3687854 /Source="Nicolas_upshifts" /id="D1954" /incds=0 /nref=155 /ntot=246 /MaxReadThrough="5.49286" /MaxDrop="6.26609" /score="19.319449" /energy="-14.5" /TU="U2964" /idTUdmin="U2959" /TUdmin=0 /isTUend="TRUE" promotor_-35 3687930..3687936 /Source="Nicolas_upshift_promotors" /id="U2965" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2901 /SigmaFactorBS="ttcaattctcctttatcagaatttaaataaaATTTGCTattt tcttcgtttTTTCTTACGATGTAGATAATaatccatttttttcaaaggggtgcagtta t" /listShort="ywfH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3687950..3687969 /Source="Nicolas_upshift_promotors" /id="U2965" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2901 /SigmaFactorBS="ttcaattctcctttatcagaatttaaataaaATTTGCTattt tcttcgtttTTTCTTACGATGTAGATAATaatccatttttttcaaaggggtgcagtta t" /listShort="ywfH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3687959 /Source="Nicolas_upshifts" /id="U2965" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2901 /SigmaFactorBS="ttcaattctcctttatcagaatttaaataaaATTTGCTattt tcttcgtttTTTCTTACGATGTAGATAATaatccatttttttcaaaggggtgcagtta t" /listShort="ywfH" /GFF_Attribute="listLong" CDS 3688000..3688779 /gene="bacG" /locus_tag="BSU_37680" /old_locus_tag="BSU37680" /EC_number="1.3.1.-" /function="16.8: Protect" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:12372825, 20052993, 23519407, 25644640" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 20052993, 23519407, 25644640; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclohexenol-containing tetrahydro-4-hydroxyphenylpyruvate H(4)HPP in bacilysin synthesis" /protein_id="NP_391648.1" /db_xref="EnsemblGenomes-Gn:BSU37680" /db_xref="EnsemblGenomes-Tr:CAB15795" /db_xref="GOA:P39644" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="PDB:3U49" /db_xref="PDB:3U4C" /db_xref="PDB:3U4D" /db_xref="SubtiList:BG10632" /db_xref="UniProtKB/Swiss-Prot:P39644" /translation="MSKRTAFVMGASQGIGKAIALKLADQHFSLVINSRNLDNIESVK EDILAKHPEASVIVLAGDMSDQHTRAGIFQKIESQCGRLDVLINNIPGGAPDTFDNCN IEDMTATFTQKTVAYIDAIKRASSLMKQNEFGRIINIVGNLWKEPGANMFTNSMMNAA LINASKNISIQLAPHNITVNCLNPGFIATDRYHQFVENVMKKNSISKQKAEEQIASGI PMKRVGSAEETAALAAFLASEEASYITGQQISADGGSMKSI*" gene 3688000..3688779 /gene="bacG" /locus_tag="BSU_37680" /old_locus_tag="BSU37680" downshifts 3688756 /Source="Nicolas_upshifts" /id="D1955" /incds=0 /nref=84 /ntot=226 /MaxReadThrough="3.12719" /MaxDrop="4.87473" /score="3.07615905" /energy="-11.9" /TU="U2965" /idTUdmin="U2964" /TUdmin=0 /isTUend="TRUE" CDS complement(3688794..3689993) /gene="bacF" /locus_tag="BSU_37690" /old_locus_tag="BSU37690" /function="16.4: Excrete" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12372825, 12670965, 15609023, 20052993, 18957859, 19061923, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 12670965, 15609023, 20052993, 18957859, 19061923, 25261512, 25472439, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanine aminotransferase forming tetrahydrotyrosine in bacilysin synthesis" /protein_id="NP_391649.1" /db_xref="EnsemblGenomes-Gn:BSU37690" /db_xref="EnsemblGenomes-Tr:CAB15796" /db_xref="GOA:P39643" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10631" /db_xref="UniProtKB/Swiss-Prot:P39643" /translation="MEITPSDVIKTLPRQEFSLVFQKVKEMEKTGAHIINLGQGNPDL PTPPHIVEALREASLNPSFHGYGPFRGYPFLKEAIAAFYKREYGVTINPETEVALFGG GKAGLYVLTQCLLNPGDIALVPNPGYPEYLSGITMARAELYEMPLYEENGYLPDFEKI DPAVLEKAKLMFLNYPNNPTGAVADAAFYAKAAAFAKEHNIHLIHDFAYGAFEFDQKP ASFLEAEDAKTVGAELYSFSKTFNMAGWRMAFAVGNEKIIQAVNEFQDHVFVGMFGGL QQAASAALSGDPEHTESLKRIYKERIDFFTALCEKELGWKMEKPKGTFYVWAEIPNTF ETSHQFSDYLLEHAHVVVTPGEIFGSNGKRHVRISMVSKQEDLREFVTRIQKLNLPFG SLQETSR*" gene complement(3688794..3689993) /gene="bacF" /locus_tag="BSU_37690" /old_locus_tag="BSU37690" CDS complement(3689994..3691178) /gene="bacE" /locus_tag="BSU_37700" /old_locus_tag="BSU37700" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12372825, 15609023, 15849754, 16850406, 18957859, 19061923, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 15609023, 15849754, 16850406, 18957859, 19061923, 25261512, 25472439, 26284661; Product type t: transporter" /codon_start=1 /transl_table=11 /product="efflux protein for bacilysin excretion, self-protection against bacilysin" /protein_id="NP_391650.1" /db_xref="EnsemblGenomes-Gn:BSU37700" /db_xref="EnsemblGenomes-Tr:CAB15797" /db_xref="GOA:P39642" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR022324" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10630" /db_xref="UniProtKB/Swiss-Prot:P39642" /translation="MKQLKPNSKYLLYGQALSFMGDYCVLPALLILSTYYHDYWVTSG VIVVRSIPMVFQPFLGVLVDRLDRIKIMLWTDIIRGIIFLGLTFLPKGEYPLIFLALL FITYGSGVFFNPARLAVMSSLESDIKSINTLFAKATTISIIVGAAAGGLFLLGGSVEL AVAFNGVTYLVSAFFISRIKLQFVPIQSENIKEAFQSFKEGLKEIKTNSFVLNAMFTM ITMALLWGVVYSYFPIVSRFLGDGEIGNFILTFCIGFGGFIGAALVSKWGFNNNRGLT YFTVLSIVSLALFLFTPIFAVSVIAAILFFIAMEYGEVLAKVKVQENAANQIQGRIFS VAEASIGLCISIGSMFINILSAPVIMGLIVVIVCGLFLHTKLVNKSFLERDNKTEQKG VF*" gene complement(3689994..3691178) /gene="bacE" /locus_tag="BSU_37700" /old_locus_tag="BSU37700" CDS complement(3691175..3692593) /gene="bacD" /locus_tag="BSU_37710" /old_locus_tag="BSU37710" /EC_number="6.3.2.49" /function="16.8: Protect" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:15609023, 16030213, 18957859, 19061923, 22298000, 22407814, 24702628, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15609023, 16030213, 18957859, 19061923, 22298000, 22407814, 24702628, 25261512, 25472439, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanine-anticapsin ligase" /protein_id="NP_391651.1" /db_xref="EnsemblGenomes-Gn:BSU37710" /db_xref="EnsemblGenomes-Tr:CAB15798" /db_xref="GOA:P39641" /db_xref="InterPro:IPR011761" /db_xref="PDB:3VMM" /db_xref="PDB:3WNZ" /db_xref="PDB:3WO0" /db_xref="PDB:3WO1" /db_xref="SubtiList:BG10629" /db_xref="UniProtKB/Swiss-Prot:P39641" /translation="MERKTVLVIADLGGCPPHMFYKSAAEKYNLVSFIPRPFAITASH AALIEKYSVAVIKDKDYFKSLADFEHPDSIYWAHEDHNKPEEEVVEQIVKVAEMFGAD AITTNNELFIAPMAKACERLGLRGAGVQAAENARDKNKMRDAFNKAGVKSIKNKRVTT LEDFRAALEEIGTPLILKPTYLASSIGVTLITDTETAEDEFNRVNDYLKSINVPKAVT FEAPFIAEEFLQGEYGDWYQTEGYSDYISIEGIMADGEYFPIAIHDKTPQIGFTETSH ITPSILDEEAKKKIVEAAKKANEGLGLQNCATHTEIKLMKNREPGLIESAARFAGWNM IPNIKKVFGLDMAQLLLDVLCFGKDADLPDGLLDQEPYYVADCHLYPQHFKQNGQIPE TAEDLVIEAIDIPDGLLKGDTEIVSFSAAAPGTSVDLTLFEAFNSIAAFELKGSNSQD VAESIRQIQQHAKLTAKYVLPV*" gene complement(3691175..3692593) /gene="bacD" /locus_tag="BSU_37710" /old_locus_tag="BSU37710" CDS complement(3692612..3693373) /gene="bacC" /locus_tag="BSU_37720" /old_locus_tag="BSU37720" /EC_number="1.1.1.385" /function="16.8: Protect" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:12372825, 15609023, 18957859, 19061923, 23317005, 25261512, 25472439, 26284661, 28158843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 15609023, 18957859, 19061923, 23317005, 25261512, 25472439, 26284661, 28158843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroanticapsin 7-dehydrogenase" /protein_id="NP_391652.2" /db_xref="EnsemblGenomes-Gn:BSU37720" /db_xref="EnsemblGenomes-Tr:CAB15799" /db_xref="GOA:P39640" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="PDB:5ITV" /db_xref="PDB:5ITW" /db_xref="SubtiList:BG10628" /db_xref="UniProtKB/Swiss-Prot:P39640" /translation="MNLTDKTVLITGGASGIGYAAVQAFLGQQANVVVADIDEAQGEA MVRKENNDRLHFVQTDITDEAACQHAVESAVHTFGGLDVLINNAGIEIVAPIHEMELS DWNKVLQVNLTGMFLMSKHALKHMLAAGKGNIINTCSVGGLVAWPDIPAYNASKGGVL QLTKSMAVDYAKHQIRVNCVCPGIIDTPLNEKSFLENNEGTLEEIKKEKAKVNPLLRL GKPEEIANVMLFLASDLSSYMTGSAITADGGYTAQ*" gene complement(3692612..3693373) /gene="bacC" /locus_tag="BSU_37720" /old_locus_tag="BSU37720" CDS complement(3693376..3694083) /gene="bacB" /locus_tag="BSU_37730" /old_locus_tag="BSU37730" /EC_number="5.3.3.19" /function="16.4: Excrete" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12372825, 14697267, 15609023, 15628860, 18957859, 19061923, 19776011, 20445239, 22483065, 22765234, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 14697267, 15609023, 15628860, 18957859, 19061923, 19776011, 20445239, 22483065, 22765234, 25261512, 25472439, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-((4R)-4-hydroxycyclohexa-1, 5-dien-1-yl)-2-oxopropanoate isomerase" /protein_id="NP_391653.1" /db_xref="EnsemblGenomes-Gn:BSU37730" /db_xref="EnsemblGenomes-Tr:CAB15800" /db_xref="GOA:P39639" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="PDB:3H7J" /db_xref="PDB:3H7Y" /db_xref="PDB:3H9A" /db_xref="SubtiList:BG10627" /db_xref="UniProtKB/Swiss-Prot:P39639" /translation="MKTKEDMQELYFPTPKLIEWENGVRQYSTVRGDTEVLMSYVPPH TNVEPHQHKEVQIGMVVSGELMMTVGDVTRKMTALESAYIAPPHVPHGARNDTDQEVI AIDIKRLKADETYTSPEDYFLDIFKTRDLLPGMEVTFFVEDWVEIMLAKIPGNGGEMP FHKHRNEQIGICIGGGYDMTVEGCTVEMKFGTAYFCEPREDHGAINRSEKESKSINIF FPPRYNRAKAKKMKADE*" gene complement(3693376..3694083) /gene="bacB" /locus_tag="BSU_37730" /old_locus_tag="BSU37730" misc_feature complement(3693979..3693980) /Source="Nicolas_upshift_promotors" /id="U2966" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.346653346653347" /xcortree=314 /SigmaFactorBS="cgaaattaattgaatgggaaaacggagtgaggcagtattcaa ccgtacgaggggatactgAAgtattaatgtcttacgtcccgccgcataccaatgttga a" /listShort="bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3693980) /Source="Nicolas_upshifts" /id="U2966" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.346653346653347" /xcortree=314 /SigmaFactorBS="cgaaattaattgaatgggaaaacggagtgaggcagtattcaa ccgtacgaggggatactgAAgtattaatgtcttacgtcccgccgcataccaatgttga a" /listShort="bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" CDS complement(3694073..3694687) /gene="bacA" /locus_tag="BSU_37740" /old_locus_tag="BSU37740" /EC_number="4.1.1.100" /function="16.4: Excrete" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12372825, 15609023, 19776011, 18957859, 19061923, 20052993, 20863139, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 15609023, 19776011, 18957859, 19061923, 20052993, 20863139, 25261512, 25472439, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate decarboxylase" /protein_id="NP_391654.1" /db_xref="EnsemblGenomes-Gn:BSU37740" /db_xref="EnsemblGenomes-Tr:CAB15801" /db_xref="GOA:P39638" /db_xref="SubtiList:BG10626" /db_xref="UniProtKB/Swiss-Prot:P39638" /translation="MIILDNSIQTKKRTDSLSKLITVNTLGPEGTSSEYAAKHFISNF TLLQGLNSKLSLHDTFESCIERTLQSPLEYTIVPHAYDGIKHFYMRPDLQLLQIFRCD TPMYGLAVRPDFEFRDDMLDTSVIVSHPSPINLIKYFTRKDVRFKLVNSTSQAARKVK EGLYDIALTNELARQKYGLTFVKTFKSIPMSWSLFGKGDVDDEN*" gene complement(3694073..3694687) /gene="bacA" /locus_tag="BSU_37740" /old_locus_tag="BSU37740" promotor_-35 3694245..3694251 /Source="Nicolas_upshift_promotors" /id="U2967" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=185 /SigmaFactorBS="cttgcggcttgactggttgaattgactAGTTTGAaacgaaca tctttgcGGGTAAAATATTTTATTAAattaataggtgaaggatgtgaaacaataacag a" /listShort="S1459" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3694267..3694285 /Source="Nicolas_upshift_promotors" /id="U2967" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=185 /SigmaFactorBS="cttgcggcttgactggttgaattgactAGTTTGAaacgaaca tctttgcGGGTAAAATATTTTATTAAattaataggtgaaggatgtgaaacaataacag a" /listShort="S1459" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3694278..3694889 /Source="Nicolas_S_feature" /locus_tag="new_3873771_3874382" /HighExp="Etha, Salt, Gly, Heat, C30, LPhT, HiTm, C90, S8, M/G" /AntisenseName="bacA" /AntisenseCor="9.8443047207874598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1459" upshifts 3694278 /Source="Nicolas_upshifts" /id="U2967" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=185 /SigmaFactorBS="cttgcggcttgactggttgaattgactAGTTTGAaacgaaca tctttgcGGGTAAAATATTTTATTAAattaataggtgaaggatgtgaaacaataacag a" /listShort="S1459" /GFF_Attribute="listLong" promotor_-10 complement(3694710..3694729) /Source="Nicolas_upshift_promotors" /id="U2968" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2947 /SigmaFactorBS="tttgtatgggaataattatcaatattttcaaaaaaCATTGAC AgttcaatttccactGGATAAAATTTACTTAAAATtttaaaagattggttggtgctca t" /listShort="bacA, bacB, bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3694726) /Source="Nicolas_upshifts" /id="U2968" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2947 /SigmaFactorBS="tttgtatgggaataattatcaatattttcaaaaaaCATTGAC AgttcaatttccactGGATAAAATTTACTTAAAATtttaaaagattggttggtgctca t" /listShort="bacA, bacB, bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" promotor_-35 complement(3694744..3694751) /Source="Nicolas_upshift_promotors" /id="U2968" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2947 /SigmaFactorBS="tttgtatgggaataattatcaatattttcaaaaaaCATTGAC AgttcaatttccactGGATAAAATTTACTTAAAATtttaaaagattggttggtgctca t" /listShort="bacA, bacB, bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3694838) /Source="Nicolas_upshifts" /id="D1956" /incds=0 /nref=1 /ntot=33 /MaxReadThrough="2.28302" /MaxDrop="5.44594" /score="19.4538123" /energy="-5.1" /TU="NA" /idTUdmin="U2969" /TUdmin=902 /isTUend="FALSE" CDS complement(3694839..3696077) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15609023, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391655.1" /db_xref="EnsemblGenomes-Gn:BSU37750" /db_xref="EnsemblGenomes-Tr:CAB15802" /db_xref="GOA:P39637" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10625" /db_xref="UniProtKB/Swiss-Prot:P39637" /translation="MNSNQNNDIKTKHHFPLLLALALTMGVFAAGSEELVISPLLPDL AKAFSSDVSVLALSISIYGVMIFIGAPLLVPLGDKYSRELSLLAGLMIFIIGTVICAL AQNIFFFFLGRALSGLAAGAFVPTAYAVVGDRVPYTYRGKVMGLIVSSWSLALIFGVP LGSFIGGVLHWRWTFWIFALMGVLVVLLILLEMRRHAQHKNSGKEEIEEPAGTFRDAL KVPRVPVYITITFCNMIGFYGMYSFLGTYLQDVFTGGNTAAGLFIMIYGIGFSMSVIT GKIADRIGKMRSLLIALGVISVLLACLPYAPASMFLLIASLFIWGLMQSLTVTLLSTI LSDCSERHRGKVMVFYSLASNLAVTLGSALMGPVYVAYGYAAVGLICAAITVLGFVLS VFAYKKYGKLEQKADQSLSQ*" gene complement(3694839..3696077) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" promotor_-10 complement(3696119..3696138) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3696131) /Source="Nicolas_upshifts" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" promotor_-35 complement(3696150..3696157) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3696287..3697699) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7540694, 8113162, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="basic aminoacid permease" /protein_id="NP_391656.1" /db_xref="EnsemblGenomes-Gn:BSU37760" /db_xref="EnsemblGenomes-Tr:CAB15803" /db_xref="GOA:P39636" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10624" /db_xref="UniProtKB/Swiss-Prot:P39636" /translation="MQNHKNELQRSMKSRHLFMIALGGVIGTGLFLGSGFTISQAGPL GAIAAYIIGGFLMYLVMLCLGELAVAMPVAGSFQAYATKFLGQSTGFMIGWLYWFSWA NTVGLELTSAGILMQRWLPSVPIWIWCLVFGIVIFLINALSVRSFAEMEFWFSSIKVA AIILFIVIGGAAVFGLIDFKGGQETPFLSNFMTDRGLFPNGVLAVMFTLVMVNFSFQG TELVGIAAGESESPEKTLPKSIRNVIWRTLFFFVLAMFVLVAILPYKTAGVIESPFVA VLDQIGIPFSADIMNFVILTAILSVANSGLYAASRMMWSLSSNQMGPSFLTRLTKKGV PMNALLITLGISGCSLLTSVMAAETVYLWCISISGMVTVVAWMSICASQFFFRRRFLA EGGNVNDLEFRTPLYPLVPILGFCLYGCVLISLIFIPDQRIGLYCGVPIIIFCYAYYH LSIKKRINHETIEKKQTEAQ*" gene complement(3696287..3697699) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" downshifts complement(3696294) /Source="Nicolas_upshifts" /id="D1957" /incds=0 /nref=16 /ntot=112 /MaxReadThrough="1.06691" /MaxDrop="5.69562" /score="41.626335" /energy="-15.9" /TU="NA" /idTUdmin="U2971" /TUdmin="-4" /isTUend="TRUE" CDS complement(3697699..3699399) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8113162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase involved in arginine and ornithine utilization" /protein_id="NP_391657.1" /db_xref="EnsemblGenomes-Gn:BSU37770" /db_xref="EnsemblGenomes-Tr:CAB15804" /db_xref="GOA:P39635" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG10623" /db_xref="UniProtKB/Swiss-Prot:P39635" /translation="MQYTKISHMNPAERVEALTASLVSLSSVNGTVGEGTKADFIKEV ITSYPYFQENPSHVWEQAIPNDPYKRKNIFAFIKGHGESRNTVIYHAHLDTVGIEDFG PLKDIAFDCEKLAEYFSRYEFDQDVQRDAKSGEWMFGRGSVDMQSGIAVHLANLLHFS ENLETLPGNVLFMANPDEESQHSGILASISELNRLKKEKQLHYLAAINTDFITPLYDG DQTRYIYTGAAGKLLPCFYIYGREVHVGDTLAGIDPNFISSEITSRLHNNIHLAEKVE GELVLPPSCLYQRDNKESYNVQTAVSTSLYFNCFIYERTAKEMMDLLIEVTEEACRET EQKLSDYYEEYVKRANLPKKHLSWGIQVYSLEQYLEKLRNRGIDPEQCIEQTFKANEH LELRMRCFQAIEELQKLDPDQGAKVILFYAPPYLPHNYLKEDSARDQLLQHVIKEAAD KTAESTGETFVFKKFFPYLADGSFLSLHETDGEIDSFIRNFPGWNMIGTIPFKDIRKL NIPSINMGVYGKDGHKWTERVYKPYTFHVLPLLIQQTTVHLLQSYRMTITAKEPKGEG *" gene complement(3697699..3699399) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" misc_feature complement(3698368..3698384) /Source="Nicolas_upshift_promotors" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3698380) /Source="Nicolas_upshifts" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" CDS complement(3699473..3701020) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11418582, 12634342, 8113162, 9383188, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-1-pyrroline-5 carboxylate dehydrogenase" /protein_id="NP_391658.1" /db_xref="EnsemblGenomes-Gn:BSU37780" /db_xref="EnsemblGenomes-Tr:CAB15805" /db_xref="GOA:P39634" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10622" /db_xref="UniProtKB/Swiss-Prot:P39634" /translation="MTVTYAHEPFTDFTEAKNKTAFGESLAFVNTQLGKHYPLVINGE KIETDRKIISINPANKEEIIGYASTADQELAEKAMQAALQAFDSWKKQRPEHRANILF KAAAILRRRKHEFSSYLVKEAGKPWKEADADTAEAIDFLEFYARQMLKLKEGAPVKSR AGEVNQYHYEALGVGIVISPFNFPLAIMAGTAVAAIVTGNTILLKPADAAPVVAAKFV EVMEEAGLPNGVLNYIPGDGAEIGDFLVEHPKTRFVSFTGSRAVGCRIYERAAKVQPG QKWLKRVIAEMGGKDTVLVDKDADLDLAASSIVYSAFGYSGQKCSAGSRAVIHQDVYD EVVEKAVALTKTLTVGNPEDPDTYMGPVIHEASYNKVMKYIEIGKSEGKLLAGGEGDD SKGYFIQPTIFADVDENARLMQEEIFGPVVAICKARDFDHMLEIANNTEYGLTGALLT KNRAHIERAREDFHVGNLYFNRGCTGAIVGYQPFGGFNMSGTDSKAGGPDYLILHMQA KTTSEAF*" gene complement(3699473..3701020) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" downshifts complement(3699480) /Source="Nicolas_upshifts" /id="D1958" /incds=0 /nref=4 /ntot=50 /MaxReadThrough="5.60027" /MaxDrop="3.5628" /score="41.626335" /energy="-15.9" /TU="U2971,U2972" /idTUdmin="U2973" /TUdmin=0 /isTUend="TRUE" upshifts complement(3701064) /Source="Nicolas_upshifts" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" S_feature complement(3701066..3701246) /Source="Nicolas_S_feature" /locus_tag="new_3880559_3880739_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1460" misc_feature complement(3701067..3701085) /Source="Nicolas_upshift_promotors" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3701247..3702521) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate dehydrogenase" /protein_id="NP_391659.2" /db_xref="EnsemblGenomes-Gn:BSU37790" /db_xref="EnsemblGenomes-Tr:CAB15806" /db_xref="GOA:P39633" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K92" /db_xref="SubtiList:BG10621" /db_xref="UniProtKB/Swiss-Prot:P39633" /translation="MSAKQVSKDEEKEALNLFLSTQTIIKEALRKLGYPGDMYELMKE PQRMLTVRIPVKMDNGSVKVFTGYRSQHNDAVGPTKGGVRFHPEVNEEEVKALSIWMT LKCGIANLPYGGGKGGIICDPRTMSFGELERLSRGYVRAISQIVGPTKDIPAPDVYTN SQIMAWMMDEYSRLREFDSPGFITGKPLVLGGSQGRETATAQGVTICIEEAVKKKGIK LQNARIIIQGFGNAGSFLAKFMHDAGAKVIGISDANGGLYNPDGLDIPYLLDKRDSFG MVTNLFTDVITNEELLEKDCDILVPAAISNQITAKNAHNIQASIVVEAANGPTTIDAT KILNERGVLLVPDILASAGGVTVSYFEWVQNNQGYYWSEEEVAEKLRSVMVSSFETIY QTAATHKVDMRLAAYMTGIRKSAEASRFRGWV*" gene complement(3701247..3702521) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" S_feature complement(3702522..3702604) /Source="Nicolas_S_feature" /locus_tag="new_3882015_3882097_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.83780600000000005" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1461" upshifts complement(3702604) /Source="Nicolas_upshifts" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" misc_feature complement(3702617..3702635) /Source="Nicolas_upshift_promotors" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3702697) /Source="Nicolas_upshifts" /id="D1959" /incds=0 /nref=9 /ntot=144 /MaxReadThrough="4.82066" /MaxDrop="4.13762" /score="22.6949864" /energy="-11.4" /TU="U2973" /idTUdmin="U2977" /TUdmin=369 /isTUend="FALSE" CDS complement(3702698..3703162) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" /experiment="publication(s) with functional evidences, PMID:15187182, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 28751732; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm protein, member of the processed secretome contributing to biofilm hydrophobicity" /protein_id="NP_391660.1" /db_xref="EnsemblGenomes-Gn:BSU37800" /db_xref="EnsemblGenomes-Tr:CAB15807" /db_xref="GOA:P39632" /db_xref="InterPro:IPR034650" /db_xref="PDB:5MKD" /db_xref="SubtiList:BG10620" /db_xref="UniProtKB/Swiss-Prot:P39632" /translation="MLKRTSFVSSLFISSAVLLSILLPSGQAHAQSASIEAKTVNSTK EWTISDIEVTYKPNAVLSLGAVEFQFPDGFHATTRDSVNGRTLKETQILNDGKTVRLP LTLDLLGASEFDLVMVRKTLPRAGTYTIKGDVVNGLGIGSFYAETQLVIDPR*" gene complement(3702698..3703162) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" S_feature complement(3703163..3703273) /Source="Nicolas_S_feature" /locus_tag="new_3882656_3882766_c" /HighExp="C90, S1, S0, MG 150, M9-tran, LPhT, BI, GM 150, Lbtran, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1462" promotor_-10 complement(3703255..3703274) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-10" upshifts complement(3703273) /Source="Nicolas_upshifts" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" promotor_-35 complement(3703289..3703296) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-35" downshifts complement(3703484) /Source="Nicolas_upshifts" /id="D1960" /incds=0 /nref=32 /ntot=80 /MaxReadThrough="3.01999" /MaxDrop="4.92444" /score="6.35246869" /energy="-8.4" /TU="U2977" /idTUdmin="U2977" /TUdmin="-418" /isTUend="FALSE" CDS complement(3703486..3703941) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" /EC_number="5.1.3.13" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25239894; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-deoxyrhamnose-3,5-epimerase (cell surface and spore coat)" /protein_id="YP_054595.1" /db_xref="EnsemblGenomes-Gn:BSU37810" /db_xref="EnsemblGenomes-Tr:CAE01469" /db_xref="GOA:Q7WY56" /db_xref="InterPro:IPR000888" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG14195" /db_xref="UniProtKB/Swiss-Prot:Q7WY56" /translation="MIDGVKVKKLMKHSDDRGFFAELVRDDENLLEHFGQASWSKSYP GVIKAFHYHEKQDDLWFFPTGHAQVVLYDLREDSKTKGETDVYYMGEDNPMLLLIPKG VAHGYRVLGETPLTIIYFTTMSYNPDQPDEKRIPWDDETIGFNWNTEFR*" gene complement(3703486..3703941) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" misc_feature 3703576..3703595 /Source="Nicolas_upshift_promotors" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3703584 /Source="Nicolas_upshifts" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3703934..3704785) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" /EC_number="1.1.1.133" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-dehydrorhamnose reductase" /protein_id="NP_391661.3" /db_xref="EnsemblGenomes-Gn:BSU37820" /db_xref="EnsemblGenomes-Tr:CAB15808" /db_xref="GOA:P39631" /db_xref="InterPro:IPR005913" /db_xref="InterPro:IPR029903" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10619" /db_xref="UniProtKB/Swiss-Prot:P39631" /translation="MTKVLVTGAGGQLGLELCRQLKQAGYEVIALTKKMMNIADQRSV RHSFGHYQPDIVVNSAAFTSVDQCEKELDKAYLINGIGAYYTALESTRIGAQYVHIST DYVFNGKGTQPYREDDPLDPKTIYGKSKRLGEELIRLTTKDSTIIRTSWVYGHGGSNF VETMLKLAETKQELRVVSDQIGSPTYTKDLAEAVIKLFSHPPGIYHVSNSGICSWYEF ATAIMEESGLETAILSVTTEEYGNKTPRPAYSVLSHRAIEEAGIRPRHWREALREYLQ ERSSACD*" gene complement(3703934..3704785) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" CDS complement(3704799..3705746) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" /EC_number="4.2.1.46" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dTDP-glucose 4,6-dehydratase" /protein_id="NP_391662.1" /db_xref="EnsemblGenomes-Gn:BSU37830" /db_xref="EnsemblGenomes-Tr:CAB15809" /db_xref="GOA:P39630" /db_xref="InterPro:IPR005888" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10618" /db_xref="UniProtKB/Swiss-Prot:P39630" /translation="MAKSYLITGGAGFIGLTFTKLMLRETDARITVLDKLTYASHPEE MEKLKQNSRFRFVKGDISVQEDIDRAFDETYDGVIHFAAESHVDRSISQAEPFITTNV MGTYRLAEAVLKGKAKKLIHISTDEVYGDLKADDPAFTETTPLSPNNPYSASKASSDL LVLSYVKTHKLPAIITRCSNNYGPYQHSEKMIPTIIRHAKQGLPVPLYGDGLQIRDWL FAEDHCRAIKLILEKGTDGEVYNIGGGNERTNKELASVILKHLGCEELFAHVEDRKGH DRRYAINASKLKNELGWRQEVTFEEGIARTIQWYTDNDR*" gene complement(3704799..3705746) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" CDS complement(3705746..3706486) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" /EC_number="2.7.7.24" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate thymidylyltransferase" /protein_id="NP_391663.1" /db_xref="EnsemblGenomes-Gn:BSU37840" /db_xref="EnsemblGenomes-Tr:CAB15810" /db_xref="GOA:P39629" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005907" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10617" /db_xref="UniProtKB/Swiss-Prot:P39629" /translation="MKGVILAGGNGSRLMPLTKAVNKHLLPVGPYPMIYWSIMKLQEA GIKDILLISQKEHMPQFYKLLGNGEELGVTITYQVQPAASGISDGLSYAKRFTKKESF ILLLGDNIFEDSLKPYTERFEQQGKGAKVLLKEVDDPERFGIAEIDEKNKRIRSIIEK PEQPPTNLCVTGIYMYDAEVFSYIEQISPSKRGELEITDVNNLYIENSQLTYDVLSGW WVDAGTHESLYLASQLVHQALRKGQDEK*" gene complement(3705746..3706486) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" promotor_-35 3706504..3706509 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3706510 /Source="Nicolas_upshifts" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3706511..3707530) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391664.1" /db_xref="EnsemblGenomes-Gn:BSU37850" /db_xref="EnsemblGenomes-Tr:CAB15811" /db_xref="GOA:P39627" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10615" /db_xref="UniProtKB/Swiss-Prot:P39627" /translation="MHVGIFADGGYEKGMGHVVRMKRLAEGLKQRCLITFYTNQDSEA FLHEEHWQVIVKPELQQHEFILREIKSKKLDLLLFDILGAPAELLKKIKTETDAKIVL FEEKNGKSIQYSDAVINGIYGDIRSRVYVQGNTRIYEGPDYLILHPAFQAAREDYTLK KDCRNILVALGGSDPKQLIFKVLAAADQVPDIKDKNMMFVMGSASPHQEAVRRRIEKK PQYKMIEQTNDMAGLMKQADAAIVAGGISLYEAICIGVPCLVLSQVEHQTATAKTFAD QGAALDLGLGELVPDETLIYQMSRIMSSYPLRLSLHKGGRPLVDGKGIIRVTAILQDL YEQEI*" gene complement(3706511..3707530) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" promotor_-10 3706524..3706542 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3707394..3707403 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3707416..3707431 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3707427 /Source="Nicolas_upshifts" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3707533..3708255) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391665.2" /db_xref="EnsemblGenomes-Gn:BSU37860" /db_xref="EnsemblGenomes-Tr:CAB15812" /db_xref="InterPro:IPR003329" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10614" /db_xref="UniProtKB/Swiss-Prot:P39626" /translation="MNDILFIIQARMGSTRLPGKVLRPLGSNRLLDILVHRVRQSAFY QKDRDNLVIATSDKETDDILEAHCIKQGFRVFRGSEERVLDRFVKVIEAVKPSVIIRL TGDNPFVDPELLDVMIQAHFDQGSDYTYILNAPLGICGEVVNANLLIDISRIQALEDQ YQEHVTLYIRNHPALYRVQFLEAPERFRAPQYRLTIDTKEDYESIKALYQKAGERPDV SASELITLLNRNPDAATEREAD*" gene complement(3707533..3708255) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" CDS complement(3708248..3709369) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" /EC_number="2.5.-.-" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12597896, 15774001; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoenolpyruvate-sugar pyruvyltransferase" /protein_id="NP_391666.1" /db_xref="EnsemblGenomes-Gn:BSU37870" /db_xref="EnsemblGenomes-Tr:CAB15813" /db_xref="GOA:P39625" /db_xref="InterPro:IPR006190" /db_xref="InterPro:IPR013132" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR036732" /db_xref="PDB:1VLI" /db_xref="SubtiList:BG10613" /db_xref="UniProtKB/Swiss-Prot:P39625" /translation="MAAFQIANKTVGKDAPVFIIAEAGINHDGKLDQAFALIDAAAEA GADAVKFQMFQADRMYQKDPGLYKTAAGKDVSIFSLVQSMEMPAEWILPLLDYCREKQ VIFLSTVCDEGSADLLQSTSPSAFKIASYEINHLPLLKYVARLNRPMIFSTAGAEISD VHEAWRTIRAEGNNQIAIMHCVAKYPAPPEYSNLSVIPMLAAAFPEAVIGFSDHSEHP TEAPCAAVRLGAKLIEKHFTIDKNLPGADHSFALNPDELKEMVDGIRKTEAELKQGIT KPVSEKLLGSSYKTTTAIEGEIRNFAYRGIFTTAPIQKGEAFSEDNIAVLRPGQKPQG LHPRFFELLTSGVRAVRDIPADTGIVWDDILLKDSPFHE*" gene complement(3708248..3709369) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" CDS complement(3709369..3710238) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative TDP-glycosamine N-acetyltransferase" /protein_id="NP_391667.1" /db_xref="EnsemblGenomes-Gn:BSU37880" /db_xref="EnsemblGenomes-Tr:CAB15814" /db_xref="GOA:P39624" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10612" /db_xref="UniProtKB/Swiss-Prot:P39624" /translation="MYTVKENVSKEAIEEFLQSRKLTLDVPYQFSLGLFENSRLQGVL LYEDSLWESKVLQKKVMNVKLLAANSTGQLKRLFEAFYTVRQMDETDFIFVRVPAEDI GAAHVIQQQPSSYFVGSLLKLAMPPSFYDKTPPFFELGPPEPGDTEAICELARDSFTK SRYFQDPHLSRDAANEIFQEWTRNNLNGRAAVNIVAKHNGEVIGYLQGLSRDDECILD LMAVKPGFEGKRIAFHLLANLIEQPETQKHRTVTAGTQLHNVRAIRLYERMGFTAEQS YYYYHIWPGKEAK*" gene complement(3709369..3710238) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" CDS complement(3710239..3711408) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" /EC_number="2.6.1.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14602648; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glutamine-dependent sugar transaminase" /protein_id="NP_391668.1" /db_xref="EnsemblGenomes-Gn:BSU37890" /db_xref="EnsemblGenomes-Tr:CAB15815" /db_xref="GOA:P39623" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10611" /db_xref="UniProtKB/Swiss-Prot:P39623" /translation="MVQKRNHFLPYSLPLIGKEEIQEVTETLESGWLSKGPKVQQFEK EFAAFVGAKHAVAVNSCTAALFLALKAKGIGPGDEVITSPLTFSSTANTIIHTGATPV FADIDENTLNIDPVKLEAAVTPRTKAVVPVHFGGQSCDMDAILAVAQNHGLFVLEDAA HAVYTTYKQRMIGSIGDATAFSFYATKNLATGEGGMLTTDDEELADKIRVLSLHGMSK AAWNRYSSNGSWYYEVESPGYKMNMFDLQAALGLHQLKRLDDMQKRREEIAGRYQTAF QQIPGLITPFVHDDGRHAWHLYVLQVDEKKAGVTRSEMITALKDEYNIGTSVHFIPVH IHPYYQKQFGYKEADFPNAMNYYKRTLSLPLYPSMSDDDVDDVIEAVRDIVKGAD*" gene complement(3710239..3711408) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" CDS complement(3711429..3712853) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22611084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP glycosyl/glycerophosphate transferase or transport" /protein_id="NP_391669.2" /db_xref="EnsemblGenomes-Gn:BSU37900" /db_xref="EnsemblGenomes-Tr:CAB15816" /db_xref="GOA:P39622" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10610" /db_xref="UniProtKB/Swiss-Prot:P39622" /translation="MSAYLSNYWVLYRKYVELFDKLRYKGIPLGLISNFYQYISPELR VMMEEEPELFGSVDQHIDEGQIQPFFEERIQNIVKTNDEPVKGKVILHFDYLRFSNEN YYQFDPEKTAVLARWSLPHYCDLPVISKREIADSCQKGDSKQYLETACSLLAPYDDHP AFGDQAFRDRLFKDIPLFIEAIDTVDALFEQEKISAVIVGTAEDIYSRVLALMCQRKG AVSICLQHGALMGDEAFIPVFTTYQAVFGAYEAEWFIRKGCKPEQILVTGHPRFDQIF NRTPMDMSIFYRKLAFQPTKKIVLIATQPFSEDFYSGVLQGLSDQKQLQIIIKPHPWE IGKNKLDLYHEAAKKHQACRVIKKELELYDLLPYVDAAVTQTSTVGLEAMLFQKPVLI GKSSGNRSYPYYESLGDFMFDQPDELAHTLVEVLRSPDVHQKAEEARLAFIAANYPVA ESTNALFAELKAKTGVDYRREDTE*" gene complement(3711429..3712853) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" CDS complement(3712858..3713628) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10350455, 11042447, 11733986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10350455, 11042447, 11733986; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat dTDP-glycosyltransferase" /protein_id="NP_391670.1" /db_xref="EnsemblGenomes-Gn:BSU37910" /db_xref="EnsemblGenomes-Tr:CAB15817" /db_xref="GOA:P39621" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PDB:1H7L" /db_xref="PDB:1H7Q" /db_xref="PDB:1QG8" /db_xref="PDB:1QGQ" /db_xref="PDB:1QGS" /db_xref="SubtiList:BG10609" /db_xref="UniProtKB/Swiss-Prot:P39621" /translation="MPKVSVIMTSYNKSDYVAKSISSILSQTFSDFELFIMDDNSNEE TLNVIRPFLNDNRVRFYQSDISGVKERTEKTRYAALINQAIEMAEGEYITYATDDNIY MPDRLLKMVRELDTHPEKAVIYSASKTYHLNENRDIVKETVRPAAQVTWNAPCAIDHC SVMHRYSVLEKVKEKFGSYWDESPAFYRIGDARFFWRVNHFYPFYPLDEELDLNYITD QSIHFQLFELEKNEFVRNLPPQRNCRELRESLKKLGMG*" gene complement(3712858..3713628) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" promotor_-10 complement(3713663..3713682) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3713677) /Source="Nicolas_upshifts" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" promotor_-35 complement(3713696..3713705) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3713796..3713801 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3713817..3713835 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3713819..3713947 /Source="Nicolas_S_feature" /locus_tag="new_3893312_3893440" /HighExp="S5, S4, S3, S7, B36, S8, S6, B60, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1463" upshifts 3713819 /Source="Nicolas_upshifts" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" CDS 3713948..3714493 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12644503, 15317760, 16936016, 16936016, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12644503, 15317760, 16936016, 16936016, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391671.1" /db_xref="EnsemblGenomes-Gn:BSU37920" /db_xref="EnsemblGenomes-Tr:CAB15818" /db_xref="GOA:P39620" /db_xref="InterPro:IPR014099" /db_xref="SubtiList:BG10608" /db_xref="UniProtKB/Swiss-Prot:P39620" /translation="MKPKKNQYQQMQAFDNMQGYQPQFGANPYPQQGQGSQMQTMGMQ PMMPMQQGQQGQQGQQGFGFPGQQQGGGFQIPSGPTPSGPGQSVPGMLPVEESYIENI LRLNRGKTATIYMTFENSKEWGSKIFRGVIEAAGRDHIIISDPKSGTRYLLLTIYLDY ITFDEEIAYTYPYSMASYSPR*" gene 3713948..3714493 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" downshifts 3714479 /Source="Nicolas_upshifts" /id="D1961" /incds=0 /nref=60 /ntot=77 /MaxReadThrough="1.98659" /MaxDrop="7.96105" /score="16.9179802" /energy="-11.7" /TU="NA" /idTUdmin="U2978" /TUdmin=0 /isTUend="TRUE" CDS complement(3714537..3714908) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15919996, 21810204; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_391672.2" /db_xref="EnsemblGenomes-Gn:BSU37930" /db_xref="EnsemblGenomes-Tr:CAB15819" /db_xref="GOA:P39619" /db_xref="InterPro:IPR006696" /db_xref="SubtiList:BG10607" /db_xref="UniProtKB/Swiss-Prot:P39619" /translation="MKVFIILGAINALLAVGLGAFGAHGLEGKIPDKYLQVWHTGVQY HMYHALGLFVVAFLADKLSGIGSVTTAGWLMFAGIVLFSGSLYILSVTQISILGAITP LGGVAFIISWIMIVVAAVKYL*" gene complement(3714537..3714908) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" downshifts complement(3714555) /Source="Nicolas_upshifts" /id="D1962" /incds=0 /nref=134 /ntot=227 /MaxReadThrough="3.65585" /MaxDrop="4.84049" /score="15.105437" /energy="-11.7" /TU="NA" /idTUdmin="U2979" /TUdmin=0 /isTUend="TRUE" CDS complement(3714970..3716292) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine/pyrimidine permease" /protein_id="NP_391673.2" /db_xref="EnsemblGenomes-Gn:BSU37940" /db_xref="EnsemblGenomes-Tr:CAB15820" /db_xref="GOA:P39618" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="SubtiList:BG10606" /db_xref="UniProtKB/Swiss-Prot:P39618" /translation="MKLVLGALQWTAFIIAAAIVVPVAVAQSFHLDHSDSARLIQSTF FVLGIAAVIQCLKGHRLPINESPAGLWWGVYTIYAGLTGTVFATYGDTLRGLQGALLV SAVCFFLLSVFKVIDRLAKLFTPVVTGVYLLLLVMQLSQPIIKGILGIGYRQDGVDGL VFGLALVVIAAAFIMTNSNIMFFKQYSILLALFGGWVLFAAAGAAKPIEMPDRLFQLP SLFPFGTPLFNSGLIITSIFITILLIVNMLASMKVVDIAMKKFSKQPDGKHHERHAGF AASFSHLLSGLTGAIAPVPISGAAGFIETTKMPSKKPFMLGSILVIVISVIPFFMNTF ASLPSPVGFAVNFVVFSAMGGLAFAEFDSYEKEESKRVRSIIGISLLTGVGIMFVPET ALKGLHPVFISLLSNGLVLGTLAAIAADQFQLWRRRKSDNLVSTENKH*" gene complement(3714970..3716292) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" CDS complement(3716312..3716629) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391674.3" /db_xref="EnsemblGenomes-Gn:BSU37950" /db_xref="EnsemblGenomes-Tr:CAB15821" /db_xref="InterPro:IPR035218" /db_xref="SubtiList:BG10605" /db_xref="UniProtKB/Swiss-Prot:P39617" /translation="MNIHISALIQKMEEELKKAKTAERDEELKRYVAVVRSLCDVVLD QPENASAPRIQPSVTPSPAAPPSTDQLMMEKMMGSAGLNKYRKQEKEKQEEDGNGESL FDF*" gene complement(3716312..3716629) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" promotor_-10 complement(3716658..3716677) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3716669) /Source="Nicolas_upshifts" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" promotor_-35 complement(3716691..3716697) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3716732..3716739 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3716755..3716774 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3716758 /Source="Nicolas_upshifts" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" CDS 3716797..3718167 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391675.2" /db_xref="EnsemblGenomes-Gn:BSU37960" /db_xref="EnsemblGenomes-Tr:CAB15822" /db_xref="GOA:P39616" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10604" /db_xref="UniProtKB/Swiss-Prot:P39616" /translation="MNSIPSIISKHKAYFAAGHTRPLESRLNILRKLKQAVRTHEADL IAALYQDLHKSEQEAYSTEIGIVLEEISFVMKRLRKWSKPKRVKTPLTHLGSKSIIIP EPYGTVLVIAPWNYPLQLALSPLIGAIAAGNTVVLKPSEYTPAVSAILSKLISSVFPT DYVAMAEGGPDVSTALLQQPFDYIFFTGSVAVGKIVMEAAAKQLIPVTLELGGKSPCI VHKDADIQLAAKRIVFGKFTNAGQTCIAPDYLFVHEDIKTKLTEEMKRAIREFYGPQP ERNPQYGKIVSERHYQRLLSFLNDGIPLTGGQSDPNHHKIAPTILEQVRDDSPVMQEE IFGPILPLFTYRNIGEVIEKVQSRPKPLALYLFTTNKEIERAVLGNLSFGGGCVNDTL MHVATPYLPFGGVGESGIGSYHGFDSFNTFTHKKSVVKQTNRFDFAFRYPSSKNGLRM IRKILK*" gene 3716797..3718167 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" CDS complement(3718192..3718869) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" /EC_number="3.2.2.27" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1902430, 9776748, 10080896, 21542855, 22056936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1902430, 9776748, 10080896, 21542855, 22056936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil-DNA glycosylase" /protein_id="NP_391676.1" /db_xref="EnsemblGenomes-Gn:BSU37970" /db_xref="EnsemblGenomes-Tr:CAB15823" /db_xref="GOA:P39615" /db_xref="InterPro:IPR002043" /db_xref="InterPro:IPR005122" /db_xref="InterPro:IPR018085" /db_xref="InterPro:IPR036895" /db_xref="PDB:3ZOQ" /db_xref="PDB:3ZOR" /db_xref="SubtiList:BG10603" /db_xref="UniProtKB/Swiss-Prot:P39615" /translation="MKQLLQDSWWNQLKEEFEKPYYQELREMLKREYAEQTIYPDSRD IFNALHYTSYDDVKVVILGQDPYHGPGQAQGLSFSVKPGVKQPPSLKNIFLELQQDIG CSIPNHGSLVSWAKQGVLLLNTVLTVRRGQANSHKGKGWERLTDRIIDVLSERERPVI FILWGRHAQMKKERIDTSKHFIIESTHPSPFSARNGFFGSRPFSRANAYLEKMGEAPI DWCIKDL*" gene complement(3718192..3718869) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" downshifts complement(3718206) /Source="Nicolas_upshifts" /id="D1963" /incds=0 /nref=66 /ntot=224 /MaxReadThrough="2.25259" /MaxDrop="4.72154" /score="26.8023311" /energy="-9.1" /TU="NA" /idTUdmin="U2982" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3718696..3718715) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3718712) /Source="Nicolas_upshifts" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3718731..3718736) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3718883..3719689) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" /EC_number="2.4.-.-" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9334165; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391677.1" /db_xref="EnsemblGenomes-Gn:BSU37980" /db_xref="EnsemblGenomes-Tr:CAB15824" /db_xref="GOA:P39614" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10602" /db_xref="UniProtKB/Swiss-Prot:P39614" /translation="MKISIVIVTYNRIPALCELLESISRQTLMPYEIIIVNDAGESVV PVKALYPELPIAVINLEKNSGHVAARNAGVKEASGDCIMLCDDDDFFTPGHIEKMAKE IETADFVHSDAEIVSFEEKNGTRYPVSRKLFAYTADYEDMRVFSTYVPSGSMYRRFLH DEIGYFDADVHNYWDWDFYLRAAKDYRVKRVPCASVIYAFSDAGDNQSADLGAKRKQY LDRLSEKHGLGELPTKNFAVLLEEPEMKRREAKSEMVWDGEPVYSRLHRS*" gene complement(3718883..3719689) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" promotor_-10 complement(3719182..3719200) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3719196) /Source="Nicolas_upshifts" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" promotor_-35 complement(3719215..3719221) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3719718..3719737) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3719724) /Source="Nicolas_upshifts" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" promotor_-35 complement(3719753..3719760) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3719779..3720312) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391678.1" /db_xref="EnsemblGenomes-Gn:BSU37990" /db_xref="EnsemblGenomes-Tr:CAB15825" /db_xref="GOA:P39613" /db_xref="SubtiList:BG10601" /db_xref="UniProtKB/Swiss-Prot:P39613" /translation="MRISSCLYGFVAHGAVFLFTGGCMLLAMAASLPFVFLLDRLPDV VFTAGAILTLLCSYAYVWFWAVRFAYNQKMRLFEVQLGSFVLLALMISLFLLDGSSMK DIMMNWDDAGCAFVPPAFTFLCLSYALVLLPVYQSKLWRLILPNGVRMKDIFHVFGDL MLIMVLLIGATLLFLSL*" gene complement(3719779..3720312) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" CDS complement(3720360..3720995) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391679.2" /db_xref="EnsemblGenomes-Gn:BSU38000" /db_xref="EnsemblGenomes-Tr:CAB15826" /db_xref="GOA:P39612" /db_xref="SubtiList:BG10600" /db_xref="UniProtKB/Swiss-Prot:P39612" /translation="MDKETYVSEIKSGLKGLPEGEAMIEEIESHIEHHLFRSFQEGKS EEEAMQTLLQAFGTPTDIVSSFKKIQPVTFRAFLMFHLFCNSALFAVGIAITIMHVWL ESPFVQAVWKGISVSVWLILAAYMIYWVLIGYQGVKEFGKRGEKLVLHTILISMVPNV IFMLVFLFNVIPAALFQSLLTPWFVGTCAFATLLFPLFGRMGCYIGRRQLV*" gene complement(3720360..3720995) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" CDS complement(3720988..3721326) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator, PadR family" /protein_id="YP_003097793.1" /db_xref="EnsemblGenomes-Gn:BSU38018" /db_xref="EnsemblGenomes-Tr:CAX52706" /db_xref="GOA:C0H3S6" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3S6" /translation="MLNRELVKGSTVILVLTLLNERPMYGYELVKEMGSRSGNELQMK EGTLYPSLHKLERQGYISSYWEKQEKGPDRKYYRITDEGKEVLAERTKEWSVFSAMMD RILKWSGQNG*" gene complement(3720988..3721326) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" promotor_-10 complement(3721348..3721367) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3721359) /Source="Nicolas_upshifts" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" promotor_-35 complement(3721382..3721389) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3721410..3721413 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3721428..3721447 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3721428 /Source="Nicolas_upshifts" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" CDS 3721470..3722285 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" /EC_number="2.7.1.35" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14973012, 17012797" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14973012, 17012797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyridoxine, pyridoxal, and pyridoxamine kinase" /protein_id="NP_391681.1" /db_xref="EnsemblGenomes-Gn:BSU38020" /db_xref="EnsemblGenomes-Tr:CAB15828" /db_xref="GOA:P39610" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="PDB:2I5B" /db_xref="SubtiList:BG10598" /db_xref="UniProtKB/Swiss-Prot:P39610" /translation="MSMHKALTIAGSDSSGGAGIQADLKTFQEKNVYGMTALTVIVAM DPNNSWNHQVFPIDTDTIRAQLATITDGIGVDAMKTGMLPTVDIIELAAKTIKEKQLK NVVIDPVMVCKGANEVLYPEHAQALREQLAPLATVITPNLFEASQLSGMDELKTVDDM IEAAKKIHALGAQYVVITGGGKLKHEKAVDVLYDGETAEVLESEMIDTPYTHGAGCTF SAAVTAELAKGAEVKEAIYAAKEFITAAIKESFPLNQYVGPTKHSALRLNQQS*" gene 3721470..3722285 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" downshifts 3722264 /Source="Nicolas_upshifts" /id="D1964" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="2.56759" /MaxDrop="5.39956" /score="22.0760698" /energy="-18.1" /TU="NA" /idTUdmin="U2985" /TUdmin=0 /isTUend="TRUE" downshifts complement(3722340) /Source="Nicolas_upshifts" /id="D1965" /incds=0 /nref=20 /ntot=111 /MaxReadThrough="0.56945" /MaxDrop="6.81686" /score="39.7901804" /energy="-16.8" /TU="NA" /idTUdmin="U2987" /TUdmin=0 /isTUend="TRUE" CDS complement(3722375..3722623) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391682.1" /db_xref="EnsemblGenomes-Gn:BSU38030" /db_xref="EnsemblGenomes-Tr:CAB15829" /db_xref="SubtiList:BG10597" /db_xref="UniProtKB/Swiss-Prot:P39609" /translation="MNIHEQKITPECLEKAANQVEDKREEYKDVLLQLKKMLGGTTPH SETAEILTRAYEQMKEYALFVQSIETFLRKSANNLKIK*" gene complement(3722375..3722623) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" downshifts complement(3722395) /Source="Nicolas_upshifts" /id="D1966" /incds=0 /nref=6 /ntot=123 /MaxReadThrough="6.75845" /MaxDrop="3.89221" /score="22.6408081" /energy="-10.8" /TU="U2987,U2988" /idTUdmin="U2986" /TUdmin=11 /isTUend="TRUE" upshifts complement(3722641) /Source="Nicolas_upshifts" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" S_feature complement(3722643..3722716) /Source="Nicolas_S_feature" /locus_tag="new_3902136_3902209_c" /HighExp="G150, Mt0, Diami, Lbexp, dia0, dia5, T0.30H, Oxctl, Etha, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.536, 0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1464" misc_feature complement(3722651..3722657) /Source="Nicolas_upshift_promotors" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3722717..3724156) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" /EC_number="3.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3100393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sucrose-6-phosphate hydrolase" /protein_id="NP_391683.2" /db_xref="EnsemblGenomes-Gn:BSU38040" /db_xref="EnsemblGenomes-Tr:CAB15830" /db_xref="GOA:P07819" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR006232" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG10596" /db_xref="UniProtKB/Swiss-Prot:P07819" /translation="MTAHDQELRRRAYEEVEKKEPIANSDPHRQHFHIMPPVGLLNDP NGVIYWKGSYHVFFQWQPFQTGHGAKFWGHYTTQDVVNWKREEIALAPSDWFDKNGCY SGSAVTKDDRLYLFYTGNVRDQDGNRETYQCLAVSDDGLSFEKKGVVARLPEGYTAHF RDPKVWEHEGTWYMVIGAQTENLKGQAVLFASDNLTEWRFLGPITGAGFNGLDDFGYM WECPDLFSLQGSDVLIVSPQGLEADGFRYQNVYQSGYFVGRLDYNKPELKHGEFTELD QGFDFYAPQTLEDDQGRRILFAWMAVPDQDEGSHPTIDCHWIHCMTLPRQLTLSGQKL IQQPLPELKAMRRNEKKIHINMHGSSGALPVEKPERTEILLEDIHTESGFSISIRGTA TFSFHKDEGIVTLERKSFDGKRTEARHCRIKDLHTVHMFLDASSVEIFINNGEEVLSA RYFPFPGNHEVTASATGKSEMNVGIWTLM*" gene complement(3722717..3724156) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" CDS complement(3724153..3725538) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" /EC_number="2.7.1.211" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1577686, 3122206, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 3122206, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) sucrose-specificenzyme IIBC component" /protein_id="NP_391684.3" /db_xref="EnsemblGenomes-Gn:BSU38050" /db_xref="EnsemblGenomes-Tr:CAB15831" /db_xref="GOA:P05306" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10595" /db_xref="UniProtKB/Swiss-Prot:P05306" /translation="MDYKETAKRLIELLGGKENIISAAHCATRLRLVMKDESKIDQAQ VEELDGVKGAFSSSGQYQIIFGTGLVNKVFDAFSKEADIEREEHVNHQDAAKEKLNPA ARFAKTLSNIFVPIIPAIVASGLLMGLLGMINAFHWMSKDSALLQLLDMFSSAAFIFL PILIGVSASKEFGSNPYLGAVIGGIMIHPNLLNPWGLAEATPDYMHLFGFDIALLGYQ GTVIPVLLAVYVMSKVEKWTRKVVPHAVDLLVTPFVTVIVTGFVAFIAIGPLGRALGS GITVALTYVYDHAGFVAGLIFGGTYSLIVLTGVHHSFHAIEAGLIADIGKNYLLPIWS MANVAQGGAGLAVFFMAKKAKTKEIALPAAFSAFLGITEPVIFGVNLRYRKPFIAAMI GGALGGAYVVFTHVAANAYGLTGIPMIAIAAPFGFSNLIHYLIGMAIAAVSAFIAAFV MKINEDEERKK*" gene complement(3724153..3725538) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" misc_feature complement(3725557..3725566) /Source="Nicolas_upshift_promotors" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3725571) /Source="Nicolas_upshifts" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" S_feature complement(3725573..3725637) /Source="Nicolas_S_feature" /locus_tag="new_3905066_3905130_c" /HighExp="Diami, G150, dia5, Mt0, M9-stat, Lbtran, Gly, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1465" promotor_-10 complement(3725616..3725633) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3725637) /Source="Nicolas_upshifts" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" promotor_-35 complement(3725649..3725656) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3725679..3725698) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3725697) /Source="Nicolas_upshifts" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" promotor_-35 complement(3725712..3725719) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3725778..3725781 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3725788 /Source="Nicolas_upshifts" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" promotor_-10 3725796..3725815 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3725840..3726610 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16207915, 16428414, 16850406, 18691156; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite transporter" /protein_id="NP_391685.1" /db_xref="EnsemblGenomes-Gn:BSU38060" /db_xref="EnsemblGenomes-Tr:CAB15832" /db_xref="GOA:P39608" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG10594" /db_xref="UniProtKB/Swiss-Prot:P39608" /translation="METQALQKVEQYALKKQNIFASSKIRYVLRSILASIFIGFGITA ASKTGSYFFMADSPFAFPAAAVTFGAAILMIAYGGGDLFTGNTFYFTYTALRKKISWR DTLYLWMSSYAGNLIGAILFAILISATGLFEEPSVHSFLIHLAEHKMEPPASELFFRG MLCNWLVCLAFFIPMSLKGEGAKLFTMMLFVFCFFISGFEHSIANMCTFAISLLIEHP DTVTLMGAVRNLIPVTLGNLTAGIVMMGWMYYTLNPDQ*" gene 3725840..3726610 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" S_feature 3726611..3727678 /Source="Nicolas_S_feature" /locus_tag="new_3906104_3907171" /HighExp="S0, ferm, M0t45, Lbexp, Mal, dia0, M/G, UNK1, M40t45, BI" /AntisenseName="sacT" /AntisenseCor="-0.34218080984654098" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1466" CDS complement(3726649..3727479) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1577686, 2163394, 8535520, 8702561, 19202299, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 2163394, 8535520, 8702561, 19202299, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator of sacAP expression" /protein_id="NP_391686.1" /db_xref="EnsemblGenomes-Gn:BSU38070" /db_xref="EnsemblGenomes-Tr:CAB15833" /db_xref="GOA:P26212" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="SubtiList:BG10593" /db_xref="UniProtKB/Swiss-Prot:P26212" /translation="MKIYKVLNNNAALIKEDDQEKIVMGPGIAFQKKKNDLIPMNKVE KIFVVRDENEKFKQILQTLPEEHIEIAEDIISYAEGELAAPLSDHIHIALSDHLSFAI ERIQNGLLVQNKLLHEIKALYKKEYEIGLWAIGHVKETLGVSLPEDEAGYIALHIHTA KMDAESMYSALKHTTMIKEMIEKIKQYFNRKVDENSISYQRLVTHLRYAVSRLESNEA LHRMDEEMLYFIQKKYSFAYQCALELAEFLKNEYQLHLPESEAGYITLHVQRLQDLSE *" gene complement(3726649..3727479) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" downshifts complement(3726650) /Source="Nicolas_upshifts" /id="D1967" /incds=0 /nref=49 /ntot=139 /MaxReadThrough="3.34691" /MaxDrop="4.9787" /score="11.2756812" /energy="-8.1" /TU="U2992" /idTUdmin="U2991" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(3727505..3727524) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3727511) /Source="Nicolas_upshifts" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" CDS complement(3727519..3727821) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391687.2" /db_xref="EnsemblGenomes-Gn:BSU38080" /db_xref="EnsemblGenomes-Tr:CAB15834" /db_xref="SubtiList:BG10592" /db_xref="UniProtKB/Swiss-Prot:P39607" /translation="MKRLLVSLRVWMVFLMNWVTPDRKTAAAAVYSAQRTYQRKAAVQ AAGLVSFYEWRMAVNEEEKQKAKAAALYKRRCLQAFKESPKQERAGPHLYMAVKRR*" gene complement(3727519..3727821) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" promotor_-35 complement(3727539..3727546) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3727822..3727960) /Source="Nicolas_S_feature" /locus_tag="new_3907315_3907453_c" /HighExp="T5.0H, M9-stat, S2, S4, T4.0H, S3, T3.30H, LoTm, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.823" /TUlongSig="NA" /TUlongPSig="NA" /label="S1467" misc_feature complement(3727945..3727964) /Source="Nicolas_upshift_promotors" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3727960) /Source="Nicolas_upshifts" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" promotor_-35 3728275..3728283 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3728294..3728312 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3728295 /Source="Nicolas_upshifts" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" CDS 3728351..3730771 /gene="vpr" /locus_tag="BSU_38090" /old_locus_tag="BSU38090" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15205417, 15596354, 16946274, 17666034, 18689487, 25666135" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15205417, 15596354, 16946274, 17666034, 18689487, 25666135; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="extracellular serine protease" /protein_id="NP_391688.1" /db_xref="EnsemblGenomes-Gn:BSU38090" /db_xref="EnsemblGenomes-Tr:CAB15835" /db_xref="GOA:P29141" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR003137" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR025965" /db_xref="InterPro:IPR034213" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="SubtiList:BG10591" /db_xref="UniProtKB/Swiss-Prot:P29141" /translation="MKKGIIRFLLVSFVLFFALSTGITGVQAAPASSKTSADLEKAEV FGDIDMTTSKKTTVIVELKEKSLAEAKEAGESQSKSKLKTARTKAKNKAIKAVKNGKV NREYEQVFSGFSMKLPANEIPKLLAVKDVKAVYPNVTYKTDNMKDKDVTISEDAVSPQ MDDSAPYIGANDAWDLGYTGKGIKVAIIDTGVEYNHPDLKKNFGQYKGYDFVDNDYDP KETPTGDPRGEATDHGTHVAGTVAANGTIKGVAPDATLLAYRVLGPGGSGTTENVIAG VERAVQDGADVMNLSLGNSLNNPDWATSTALDWAMSEGVVAVTSNGNSGPNGWTVGSP GTSREAISVGATQLPLNEYAVTFGSYSSAKVMGYNKEDDVKALNNKEVELVEAGIGEA KDFEGKDLTGKVAVVKRGSIAFVDKADNAKKAGAIGMVVYNNLSGEIEANVPGMSVPT IKLSLEDGEKLVSALKAGETKTTFKLTVSKALGEQVADFSSRGPVMDTWMIKPDISAP GVNIVSTIPTHDPDHPYGYGSKQGTSMASPHIAGAVAVIKQAKPKWSVEQIKAAIMNT AVTLKDSDGEVYPHNAQGAGSARIMNAIKADSLVSPGSYSYGTFLKENGNETKNETFT IENQSSIRKSYTLEYSFNGSGISTSGTSRVVIPAHQTGKATAKVKVNTKKTKAGTYEG TVIVREGGKTVAKVPTLLIVKEPDYPRVTSVSVSEGSVQGTYQIETYLPAGAEELAFL VYDSNLDFAGQAGIYKNQDKGYQYFDWDGTINGGTKLPAGEYYLLAYAANKGKSSQVL TEEPFTVE*" gene 3728351..3730771 /gene="vpr" /locus_tag="BSU_38090" /old_locus_tag="BSU38090" upshifts 3728509 /Source="Nicolas_upshifts" /id="U2994" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.677322677322677" /psig="0.986013986013986" /xcortree=625 /SigmaFactorBS="aaaaacgtcggctgatctggaaaaagccgaggtattcggtga tatcgatatgacgacaagcaaaaaaacAACCGTTATAGTGGAATTAAaagaaaaatcc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 3728518..3728537 /Source="Nicolas_upshift_promotors" /id="U2994" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.677322677322677" /psig="0.986013986013986" /xcortree=625 /SigmaFactorBS="aaaaacgtcggctgatctggaaaaagccgaggtattcggtga tatcgatatgacgacaagcaaaaaaacAACCGTTATAGTGGAATTAAaagaaaaatcc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 3730759 /Source="Nicolas_upshifts" /id="D1968" /incds=0 /nref=7 /ntot=104 /MaxReadThrough="0.60305" /MaxDrop="5.33856" /score="26.8487936" /energy="-16.5" /TU="NA" /idTUdmin="U2993" /TUdmin=6 /isTUend="TRUE" CDS complement(3730809..3731810) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913069, 15774866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative monooxygenase" /protein_id="NP_391689.1" /db_xref="EnsemblGenomes-Gn:BSU38100" /db_xref="EnsemblGenomes-Tr:CAB15836" /db_xref="GOA:P39606" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10590" /db_xref="UniProtKB/Swiss-Prot:P39606" /translation="MVSLSILDQSPVSEGSNAETALQQTVALAQAAEDLGYKRFWVSE HHFSKRLAGSSPEVLISHIAAKTKRIRVGSGGVMLPHYSAYKVAENFRVLEGLTPGRI DLGLGRAPGGMPIASWALNDGGKRNADQYPQQIKELTMYLHDLADDKHRFPNLTAAPH ISTAPDVWLLGSSGESALLAAESGAGYMFAHFINGEGGEGTVRQYKRRFKPSVLGDTP RAAVAVFVLCADTEEKAEELGAVLDFTLLAGEQGIPLEGVPSYEAVRKNTYSPYEQRR IADNRNRMIVGTKEQVKERLLALSNAYETEEIMVVTITHHFEDKLRSYRLLQEAFAD* " gene complement(3730809..3731810) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" S_feature complement(3731811..3731972) /Source="Nicolas_S_feature" /locus_tag="new_3911304_3911465_c" /HighExp="Etha, Diami, dia15, LPhT, dia5, H2O2, B60, LBGstat, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1468" CDS complement(3731984..3732733) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" /EC_number="1.5.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-containing NADPH-linked nitro/flavin reductase" /protein_id="NP_391690.1" /db_xref="EnsemblGenomes-Gn:BSU38110" /db_xref="EnsemblGenomes-Tr:CAB15837" /db_xref="GOA:P39605" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR016446" /db_xref="InterPro:IPR029479" /db_xref="PDB:3N2S" /db_xref="SubtiList:BG10589" /db_xref="UniProtKB/Swiss-Prot:P39605" /translation="MNNTIETILNHRSIRSFTDQLLTAEEIDTLVKSAQAASTSSYVQ AYSIIGVSDPEKKRELSVLAGNQPYVEKNGHFFVFCADLYRHQQLAEEKGEHISELLE NTEMFMVSLIDAALAAQNMSIAAESMGLGICYIGGIRNELDKVTEVLQTPDHVLPLFG LAVGHPANLSGKKPRLPKQAVYHENTYNVNTDDFRHTMNTYDKTISDYYRERTNGKRE ETWSDQILNFMKQKPRTYLNDYVKEKGFNKN*" gene complement(3731984..3732733) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" downshifts complement(3732017) /Source="Nicolas_upshifts" /id="D1969" /incds=0 /nref=11 /ntot=191 /MaxReadThrough="5.92216" /MaxDrop="3.39651" /score="17.7447455" /energy="-9.9" /TU="U2995" /idTUdmin="U2996" /TUdmin=770 /isTUend="FALSE" promotor_-10 complement(3732751..3732770) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3732768) /Source="Nicolas_upshifts" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" promotor_-35 complement(3732785..3732788) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3732839..3734020) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9622350, 15612918, 15849754, 16850406, 28085152" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 15612918, 15849754, 16850406, 28085152; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycosyltransferase involved in extension of thelateral walls of the cell" /protein_id="NP_391691.1" /db_xref="EnsemblGenomes-Gn:BSU38120" /db_xref="EnsemblGenomes-Tr:CAB15838" /db_xref="GOA:P39604" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10588" /db_xref="UniProtKB/Swiss-Prot:P39604" /translation="MSRYKKQQSPFYQGDLIFIFGVFFIISVVSIYAAGQFGQYGNTD WIQQIVFYLLGAVAITVLLYFDLEQLEKLSLYIFIIGILSLIILKISPESIAPVIKGA KSWFRIGRITIQPSEFMKVGLIMMLASVIGKANPKGVRTLRDDIHLLLKIAGVAVIPV GLILMQDAGTAGICMFIVLVMVFMSGINWKLIAIIAGSGILLISLILLVMINFPDVAK SVGIQDYQIKRVTSWVSASNETQEDSNDSWQVDQAIMAIGSGGILGNGISNLKVYVPE STTDFIFSIIGESFGFIGCAIVVIMFFFLIYRLVVLIDKIHPFNRFASFFCVGYTALI VIHTFQNIGMNIGIMPVTGIPLLFVSYGGSSTLSTLIGFGIVYNASVQLTKYRSYLFN S*" gene complement(3732839..3734020) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" downshifts complement(3732853) /Source="Nicolas_upshifts" /id="D1970" /incds=0 /nref=20 /ntot=124 /MaxReadThrough="3.38052" /MaxDrop="5.67563" /score="31.4805549" /energy="-13.3" /TU="U2996" /idTUdmin="U2996" /TUdmin="-66" /isTUend="FALSE" S_feature complement(3734021..3734152) /Source="Nicolas_S_feature" /locus_tag="new_3913514_3913645_c" /HighExp="Heat, T0.30H, H2O2, T1.0H, Salt, Paraq, T1.30H, LBGstat, Oxctl, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1469" promotor_-10 complement(3734146..3734161) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-10" upshifts complement(3734152) /Source="Nicolas_upshifts" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" promotor_-35 complement(3734173..3734182) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-35" promotor_-35 3734387..3734394 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3734405..3734515 /Source="Nicolas_S_feature" /locus_tag="new_3913898_3914008" /HighExp="M9-stat, T0.30H, T1.30H, T1.0H, T4.0H, T2.30H, T3.30H, T3.0H, T5.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1470" promotor_-10 3734405..3734424 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3734405 /Source="Nicolas_upshifts" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" CDS 3734516..3734779 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16159778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159778; Product type f: factor" /codon_start=1 /transl_table=11 /product="holin-like protein required for proper spore morphogenesis and germination" /protein_id="NP_391692.1" /db_xref="EnsemblGenomes-Gn:BSU38130" /db_xref="EnsemblGenomes-Tr:CAB15839" /db_xref="GOA:P39603" /db_xref="InterPro:IPR020185" /db_xref="SubtiList:BG10587" /db_xref="UniProtKB/Swiss-Prot:P39603" /translation="MMDMFFAYLLVASATPLFIWLDNKKVALSAIPPIILMWVFFFFY ATESLSPLGHTLMIILFAVNVIVAHIAAFIIYGLPYLRRKRSS*" gene 3734516..3734779 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" downshifts 3734669 /Source="Nicolas_upshifts" /id="D1971" /incds=1 /nref=1 /ntot=99 /MaxReadThrough="6.85004" /MaxDrop="2.5697" /score="27.9247684" /energy="-11.4" /TU="U2997" /idTUdmin="U2997" /TUdmin="-110" /isTUend="FALSE" downshifts 3734785 /Source="Nicolas_upshifts" /id="D1972" /incds=0 /nref=7 /ntot=90 /MaxReadThrough="2.04756" /MaxDrop="6.52141" /score="27.9247684" /energy="-11.4" /TU="NA" /idTUdmin="U2997" /TUdmin=6 /isTUend="TRUE" CDS complement(3734822..3735196) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit IV)" /protein_id="NP_391693.1" /db_xref="EnsemblGenomes-Gn:BSU38140" /db_xref="EnsemblGenomes-Tr:CAB15840" /db_xref="GOA:P34959" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014250" /db_xref="SubtiList:BG10586" /db_xref="UniProtKB/Swiss-Prot:P34959" /translation="MANKSAEHSHFPWKHIVGFILSIVLTLLALWVAVYTDLSSSAKL WIIFGFAFIQAALQLLMFMHMTESENGTIQVGNTLFGFFGAIVIVLGSIWIFAAHYHH GDHMDGNPPGGAEHSEHSGHNE*" gene complement(3734822..3735196) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" downshifts complement(3734833) /Source="Nicolas_upshifts" /id="D1973" /incds=0 /nref=222 /ntot=267 /MaxReadThrough="2.42368" /MaxDrop="9.0593" /score="21.3154492" /energy="-11.4" /TU="NA" /idTUdmin="U3000" /TUdmin=0 /isTUend="TRUE" CDS complement(3735198..3735812) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit III)" /protein_id="NP_391694.1" /db_xref="EnsemblGenomes-Gn:BSU38150" /db_xref="EnsemblGenomes-Tr:CAB15841" /db_xref="GOA:P34958" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR014246" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10585" /db_xref="UniProtKB/Swiss-Prot:P34958" /translation="MEHAEHGNSNAPMEYQSETGRLNILGFWIFLGAEIVLFSTLFAT FFVLKNRTAGGVLPDELFEVNLVMIMTFLLLISSFTCGIAVHEMRRGSLKGVVIWTII TLLLGAGFVGCEINEFVHYVHEGAALSTSAFWSGFFVLLGTHGTHVTIGIFWITGILI QLKKRGLTPQTSSKIFISSLYWHFLDVVWIFIFTGVYLMGLGGL*" gene complement(3735198..3735812) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" CDS complement(3735826..3737775) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit I)" /protein_id="NP_391695.1" /db_xref="EnsemblGenomes-Gn:BSU38160" /db_xref="EnsemblGenomes-Tr:CAB15842" /db_xref="GOA:P34956" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014233" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10584" /db_xref="UniProtKB/Swiss-Prot:P34956" /translation="MKFKWDEFFVTGDPLILGAQVSIALSTIAIIFVLTYFKKWKWLW SEWITTVDHKKLGIMYIISAVIMLFRGGVDGLMMRAQLALPNNSFLDSNHYNEIFTTH GTIMIIFMAMPFLIGLINVVVPLQIGARDVAFPYLNNLSFWTFFVGAMLFNISFVIGG SPNAGWTSYMPLASNDMSPGPGENYYLLGLQIAGIGTLMTGINFMVTILKMRTKGMTL MRMPMFTWTTLITMVIIVFAFPVLTVALALLSFDRLFGAHFFTLEAGGMPMLWANLFW IWGHPEVYIVILPAFGIFSEIISSFARKQLFGYKAMVGSIIAISVLSFLVWTHHFFTM GNSASVNSFFSITTMAISIPTGVKIFNWLFTMYKGRISFTTPMLWALAFIPNFVIGGV TGVMLAMAAADYQYHNTYFLVSHFHYVLIAGTVFACFAGFIFWYPKMFGHKLNERIGK WFFWIFMIGFNICFFPQYFLGLQGMPRRIYTYGPNDGWTTLNFISTVGAFMMGVGFLI LCYNIYYSFRYSTREISGDSWGVGRTLDWATSSAIPPHYNFAVLPEVKSQDAFLHMKE EKTELYPESKFKKIHMPSNSGRPFFMSVAFGLAGFGLVFEWYWMGVVGLIGVLLCMVL RSFEYDNGYYISVDEIKETERKISE*" gene complement(3735826..3737775) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" misc_feature 3737039..3737058 /Source="Nicolas_upshift_promotors" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3737045 /Source="Nicolas_upshifts" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_no_box 3737469..3737569 /Source="Nicolas_upshift_promotors" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3737529 /Source="Nicolas_upshifts" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 3737639 /Source="Nicolas_upshifts" /id="D1974" /incds=1 /nref=1 /ntot=73 /MaxReadThrough="3.07388" /MaxDrop="3.44223" /score="-7.14620582" /energy="-8.1" /TU="U2999" /idTUdmin="U2999" /TUdmin="-154" /isTUend="FALSE" CDS complement(3737803..3738768) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 22720735, 26196462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit II)" /protein_id="NP_391696.2" /db_xref="EnsemblGenomes-Gn:BSU38170" /db_xref="EnsemblGenomes-Tr:CAB15843" /db_xref="GOA:P34957" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR006332" /db_xref="InterPro:IPR006333" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR034227" /db_xref="InterPro:IPR036257" /db_xref="SubtiList:BG10583" /db_xref="UniProtKB/Swiss-Prot:P34957" /translation="MIFLFRALKPLLVLALLTVVFVLGGCSNASVLDPKGPVAEQQSD LILLSIGFMLFIVGVVFVLFTIILVKYRDRKGKDNGSYNPEIHGNTFLEVVWTVIPIL IVIALSVPTVQTIYSLEKAPEATKDKEPLVVYATSVDWKWVFSYPEQDIETVNYLNIP VDRPILFKISSADSMASLWIPQLGGQKYAMAGMLMDQYLQADKVGTYEGRNANFTGEH FADQEFDVNAVTEKDFNSWVKKTQNEAPKLTKEKYDELMLPENVDELTFSSTHLKYVD HGQDAEYAMEARKRLGYQAVSPHSKTDPFENVKKNEFKKSDDTEE*" gene complement(3737803..3738768) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" S_feature complement(3738769..3738837) /Source="Nicolas_S_feature" /locus_tag="new_3918262_3918330_c" /HighExp="M0t90, M40t90, Lbtran, Lbstat, M40t45, S2, nit, ferm, LBGstat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="0.626, 1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1471" promotor_-10 complement(3738824..3738843) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3738837) /Source="Nicolas_upshifts" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" S_feature complement(3738839..3739024) /Source="Nicolas_S_feature" /locus_tag="new_3918332_3918517_c" /HighExp="LBGstat, Heat, G150, G135, LBGtran, G180, BMM, Salt, LBGexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1472" promotor_-35 complement(3738856..3738860) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3738955..3738960 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3738976..3738994 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3738981 /Source="Nicolas_upshifts" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3739015..3739034) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3739024) /Source="Nicolas_upshifts" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" S_feature complement(3739026..3739135) /Source="Nicolas_S_feature" /locus_tag="new_3918519_3918628_c" /HighExp="Heat, Salt, LBGstat, BMM, Oxctl, H2O2, MG 15, UNK1, MG-0.1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1473" promotor_-35 complement(3739049..3739053) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3739091 /Source="Nicolas_upshifts" /id="D1975" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.69533" /MaxDrop="4.01393" /score="13.5410442" /energy="-16.4" /TU="U3001" /idTUdmin="U3001" /TUdmin="-44" /isTUend="FALSE" promotor_-10 complement(3739120..3739139) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3739135) /Source="Nicolas_upshifts" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" promotor_-35 complement(3739155..3739159) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3739213..3739231) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3739218..3739224 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3739230) /Source="Nicolas_upshifts" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" promotor_-10 3739239..3739257 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3739242 /Source="Nicolas_upshifts" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" promotor_-35 complement(3739247..3739252) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3739284..3739529 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391697.2" /db_xref="EnsemblGenomes-Gn:BSU38180" /db_xref="EnsemblGenomes-Tr:CAB15844" /db_xref="GOA:O32282" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG14162" /db_xref="UniProtKB/Swiss-Prot:O32282" /translation="MSFLISLIVAIIIGWLGSLFVKGDMPGGIIGSMIAGLIGAWIGH GLLGTWGPHLAGFAIIPAVIGAAIVVFLVSLLTRKRG*" gene 3739284..3739529 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" downshifts 3739511 /Source="Nicolas_upshifts" /id="D1976" /incds=0 /nref=125 /ntot=189 /MaxReadThrough="2.63086" /MaxDrop="7.72876" /score="13.5410442" /energy="-16.4" /TU="NA" /idTUdmin="U3005" /TUdmin=1 /isTUend="TRUE" CDS complement(3739600..3741141) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" /EC_number="2.7.7.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917, 11790749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917, 11790749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactose-1-phosphate uridyltransferase" /protein_id="NP_391698.2" /db_xref="EnsemblGenomes-Gn:BSU38190" /db_xref="EnsemblGenomes-Tr:CAB15845" /db_xref="GOA:P39575" /db_xref="InterPro:IPR000766" /db_xref="InterPro:IPR005849" /db_xref="InterPro:IPR005850" /db_xref="InterPro:IPR023425" /db_xref="SubtiList:BG10582" /db_xref="UniProtKB/Swiss-Prot:P39575" /translation="MSIIEHLEQLLEYGLERKLISIWDREYTRNRLYEALGITHPEPN SSTSIKQSQSLPDLLAPIYKWAAETGRMEADTDTYRDLLSAKLMGCFVPAPSEVIRKF EETKALYGPKQATKEFYQYSEDVYYIRTDRIAKNVHWTVPTEYGELEMTINLSKPEKD PKAIAAAKEQEQTNYPMCLLCKENVGFEGSVNHPARQNHRIIPVILEDEQWFLQFSPY VYYPEHCIVLKGEHEPMEISKKTFERLLSFLGQYPHYFIGSNADLPIVGGSILSHDHF QGGAHDFPMARAEAEDVYELNDYPGVSLGLVKWPMSVLRLQGDEPGHVAEAADHIFRT WQTYSDEKAGIAAYTGDTPHNTVTPIARRRGDLYELDIVLRNNRTDEEHPLGIFHPHQ EVHHIKKENIGLIEVMGLAILPGRLQEEMKETAAALCSADPKTALEQNPLTAKHSEWA LRTMEKRTITKENVDLVIKEELGHVFARILEHAGVFKQTAEGKQAFRRFIDQLGAKPV KSLNR*" gene complement(3739600..3741141) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" downshifts complement(3739629) /Source="Nicolas_upshifts" /id="D1977" /incds=0 /nref=190 /ntot=254 /MaxReadThrough="0.3431" /MaxDrop="6.63153" /score="21.0691542" /energy="-14.7" /TU="NA" /idTUdmin="U3006" /TUdmin=0 /isTUend="TRUE" CDS complement(3741145..3742317) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" /EC_number="2.7.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactokinase" /protein_id="NP_391699.1" /db_xref="EnsemblGenomes-Gn:BSU38200" /db_xref="EnsemblGenomes-Tr:CAB15846" /db_xref="GOA:P39574" /db_xref="InterPro:IPR000705" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR006206" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR019539" /db_xref="InterPro:IPR019741" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022963" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10581" /db_xref="UniProtKB/Swiss-Prot:P39574" /translation="MREELKGIFASVFGEKEGLRFFFAPGRVNLIGEHTDYNGGHVFP CALTMGTYAAVAERNDGLVRMYSDNFRNAGIKECSLDDIRYQKEDDWANYPKGVIYEF QQRGYAVPHGFDIVFSGNIPNGAGLSSSASIELLMGVVLQSYFHPEVDALELVKMAQH AENHFIGVNCGIMDQFAIGMGKKHHAMLLNCDTLDYEYSKLNVSGLALVIANTNKKRT LADSSYNTRRQECNDALLDLKKGLDIAALGDIKPSDFDAHSSLIQNETNRRRAKHAVY ENHRAIKTAHMFKENNIDEIGQLMKESHLSLKDDYEVTCPELDELVFAAWDHEGVIGS RMTGAGFGGCTISIVKDEFVDDFIQKVGDRYQEKTGLRADFYVADIGEGARELKGE*" gene complement(3741145..3742317) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" promotor_-10 complement(3742335..3742353) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3742357) /Source="Nicolas_upshifts" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" promotor_-35 complement(3742368..3742374) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3742398..3742781) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882654, 15849754, 16850406, 18192405; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall glycosylation protein" /protein_id="NP_391700.1" /db_xref="EnsemblGenomes-Gn:BSU38210" /db_xref="EnsemblGenomes-Tr:CAB15847" /db_xref="GOA:P39602" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG10580" /db_xref="UniProtKB/Swiss-Prot:P39602" /translation="MYIIMGVFTTIVNIASFYILVEIMNVDYKAATVAAWILSVLFAY ITNKLYVFQQKTHDLQSLLKELTAFFSVRVLSLGIDLGMMIILVGQFNTNETLAKILD NAVIVVVNYVASKWLVFKKTKEEGV*" gene complement(3742398..3742781) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" CDS complement(3742799..3743470) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of slrA (biofilm formation)" /protein_id="NP_391701.2" /db_xref="EnsemblGenomes-Gn:BSU38220" /db_xref="EnsemblGenomes-Tr:CAB15848" /db_xref="GOA:P39601" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10579" /db_xref="UniProtKB/Swiss-Prot:P39601" /translation="MKKNKFQIKREATFESFIDAGVNLLIDRAYDPVSVEDISRAAGY SKGAFYVHFVSKDDFLLYLLEKRQMKKKIIIGYLDQMERESVKSLTLDEAAKHAAELL YSYYINKPSWDITSFAMNMPTYKVLKKCKAYVRLYELWVEENVLYIKWLKERKLIDAC IDPEYTAKIICAVLDGIIKQSYVLGQPATFRSFLDALSVFFTLDREHERPRILKSFSE SEEHQ*" gene complement(3742799..3743470) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" promotor_-10 complement(3743492..3743511) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3743501) /Source="Nicolas_upshifts" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" promotor_-35 complement(3743527..3743530) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3743611..3743614 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3743629..3743648 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3743638..3743825 /Source="Nicolas_S_feature" /locus_tag="new_3923131_3923318" /HighExp="T0.30H, T1.0H, Cold, T1.30H, HiOs, T-0.40H, T2.0H, T2.30H, T4.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1474" upshifts 3743638 /Source="Nicolas_upshifts" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" CDS 3743826..3743984 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168, 26857544" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168, 26857544; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-repressor of SlrR" /protein_id="YP_003097794.1" /db_xref="EnsemblGenomes-Gn:BSU38229" /db_xref="EnsemblGenomes-Tr:CAX52707" /db_xref="GOA:P0C8M5" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="UniProtKB/Swiss-Prot:P0C8M5" /translation="MKTHVKKDLDKGWHMLIQEARSIGLGIHDVRQFLESETASRKKN HKKTVRQD*" gene 3743826..3743984 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" S_feature 3743985..3744369 /Source="Nicolas_S_feature" /locus_tag="new_3923478_3923862" /HighExp="T0.30H, Cold, T1.30H, T2.0H, T1.0H, HiOs, T2.30H, T3.0H, LBGstat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1475" promotor_-35 3744350..3744355 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3744371..3744389 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3744371 /Source="Nicolas_upshifts" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" CDS 3744427..3744735 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of acetate transporter as a volatile signal for biofilm formation" /protein_id="NP_391702.1" /db_xref="EnsemblGenomes-Gn:BSU38230" /db_xref="EnsemblGenomes-Tr:CAB15849" /db_xref="GOA:P39600" /db_xref="InterPro:IPR007436" /db_xref="SubtiList:BG10578" /db_xref="UniProtKB/Swiss-Prot:P39600" /translation="MYKADYKQIAATPSFQAFLKQKRAFIVPSAIFFFVFYFSLPVLT SYFTFLNAPAIGAVSWAWLFAIAQFAMTWILSTVYSRRAAHFDKYVSALKEDLKGEQT *" gene 3744427..3744735 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" downshifts complement(3744513) /Source="Nicolas_upshifts" /id="D1978" /incds=1 /nref=3 /ntot=15 /MaxReadThrough="0.42282" /MaxDrop="5.4957" /score="10.1452497" /energy="-8.3" /TU="NA" /idTUdmin="U3010" /TUdmin=0 /isTUend="TRUE" promotor_no_box complement(3744517..3744617) /Source="Nicolas_upshift_promotors" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3744557) /Source="Nicolas_upshifts" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 3744732..3746273 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="acetate Na+-dependent symporter subunit involvedin volatile signal for biofilm formation" /protein_id="NP_391703.2" /db_xref="EnsemblGenomes-Gn:BSU38240" /db_xref="EnsemblGenomes-Tr:CAB15850" /db_xref="GOA:P39599" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG10577" /db_xref="UniProtKB/Swiss-Prot:P39599" /translation="MNMTAFLLFLAIVGLTLIITYFAAKRTKTTSEFYTAGGGLTGVQ NGLAIAGDYMSAASFLGIAGMIALYGFDGFFYSIGFLVAYLVVLYIVAEPLRNLGKYT MADMIAARFKEKKIRGVAALNTIAISTFYMIAQLVGAGALIKLLLGLDYTAAVLIVGV LMTIYVVFGGMIATSWVQIIKAVLLMAGTLVISIIVFSKFGFSLNTMFEQMKTATPLG ADFLNPGNKYKVPLETLSLNLALVLGTAGLPHILIRFYTVKDAKTARTSVVSATWIIG VFYIMTVFLGFGAAAFVGFDAITAADQAGNMAAPLLAKALGGDFLFAFVSAIAFATIL AVVTGLVLSAASAFAHDIYSQIIRKGEATEKEQMKAARWASVAVSVLSILLAIFAQSL NVAFLVALAFAVAASANLPLIVFTVFWKRFNASGALWGSLTGLISALVLVSMSPSVWD PAGGAIFTGDPLIPLSNPGIISIPLGFLGAWLGTVLSSDKTIDEDTFAEIQVKAHTGV HMEQE*" gene 3744732..3746273 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" downshifts 3746264 /Source="Nicolas_upshifts" /id="D1979" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="2.40129" /MaxDrop="4.15104" /score="2.66606932" /energy="-7.8" /TU="NA" /idTUdmin="U3009" /TUdmin=0 /isTUend="TRUE" CDS complement(3746304..3746906) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reductase" /protein_id="NP_391704.1" /db_xref="EnsemblGenomes-Gn:BSU38250" /db_xref="EnsemblGenomes-Tr:CAB15851" /db_xref="GOA:P39598" /db_xref="InterPro:IPR001853" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10576" /db_xref="UniProtKB/Swiss-Prot:P39598" /translation="MTVHIKVYSDYVCPFCFVGKAAFEEAIKGKDVEVEWMPFELRPS PSPQLDPVNDPSKQYMWQTSIQPMAEKLGVEINFPNVSPHPYTDLAFEGFHFAKEYNK GHEYNTRVFQAFFQEDQNIGDIDILTKLAEEVGLDGASFKSALETRTYQDVQRQALKH AYEEADITAVPTFIIGDTVIPGAAGKDVFEKAISDEQKKK*" gene complement(3746304..3746906) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" downshifts complement(3746318) /Source="Nicolas_upshifts" /id="D1980" /incds=0 /nref=12 /ntot=123 /MaxReadThrough="1.89374" /MaxDrop="3.51247" /score="21.9354981" /energy="-7.8" /TU="NA" /idTUdmin="U3011" /TUdmin=0 /isTUend="TRUE" S_feature complement(3746907..3747188) /Source="Nicolas_S_feature" /locus_tag="new_3926400_3926681_c" /HighExp="T1.0H, G135, G150, T1.30H, Lbexp, G180, Lbstat, dia5, LBGexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.984, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1476" CDS complement(3747189..3748439) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" /EC_number="1.11.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxidase converting ferric iron into ferrous iron" /protein_id="NP_391705.1" /db_xref="EnsemblGenomes-Gn:BSU38260" /db_xref="EnsemblGenomes-Tr:CAB15852" /db_xref="GOA:P39597" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR006313" /db_xref="InterPro:IPR006314" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019546" /db_xref="SubtiList:BG10575" /db_xref="UniProtKB/Swiss-Prot:P39597" /translation="MSDEQKKPEQIHRRDILKWGAMAGAAVAIGASGLGGLAPLVQTA AKPSKKDEKEEEQIVPFYGKHQAGITTAHQTYVYFAALDVTAKDKSDIITLFRNWTSL TQMLTSGKKMSAEQRNQYLPPQDTGESADLSPSNLTVTFGFGPGFFEKDGKDRFGLKS KKPKHLAALPAMPNDNLDEKQGGGDICIQVCADDEQVAFHALRNLLNQAVGTCEVRFV NKGFLSGGKNGETPRNLFGFKDGTGNQSTKDDTLMNSIVWIQSGEPDWMTGGTYMAFR KIKMFLEVWDRSSLKDQEDTFGRRKSSGAPFGQKKETDPVKLNQIPSNSHVSLAKSTG KQILRRAFSYTEGLDPKTGYMDAGLLFISFQKNPDNQFIPMLKALSAKDALNEYTQTI GSALYACPGGCKKGEYIAQRLLES*" gene complement(3747189..3748439) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" downshifts complement(3747285) /Source="Nicolas_upshifts" /id="D1981" /incds=1 /nref=67 /ntot=232 /MaxReadThrough="5.0552" /MaxDrop="3.65898" /score="21.9354981" /energy="-7.8" /TU="U3011,U3012" /idTUdmin="U3011" /TUdmin="-967" /isTUend="FALSE" CDS complement(3748458..3749615) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipoprotein binding ferrous or ferric iron for transport" /protein_id="NP_391706.1" /db_xref="EnsemblGenomes-Gn:BSU38270" /db_xref="EnsemblGenomes-Tr:CAB15853" /db_xref="GOA:P39596" /db_xref="InterPro:IPR018976" /db_xref="InterPro:IPR034981" /db_xref="SubtiList:BG10574" /db_xref="UniProtKB/Swiss-Prot:P39596" /translation="MNFTKIAVSAGCILALCAGCGANDTSSTKEKASSEKSGVTKEIT ASVNKMETIISKLNDSVEKGDQKEIEKKGKELNSYWLSFENDIRSDYPFEYTEIEKHL QPIYTEAQKDKPDAGKIKTESESLKASLEDLTEAKKSGKKASDQLAKAADEYKGYVKE QSDQLVKATEAFTGAVKSGDIEKSKTLYAKARVYYERIEPIAESLGDLDPKIDAREND VEEGDKWTGFHKLEKAIWKDQDISGEKATADQLLKDVKELDGSIQSLKLTPEQIVAGA MELLNEAGISKITGEEERYSRIDLVDLMANVEGSEAVYQTVKSALVKDHSDLTEKLDT EFSEFEVLMAKYKTNDQSYTSYDKLSEKQIRELSTKLTTLSETMSKIANVL*" gene complement(3748458..3749615) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" misc_feature complement(3748531..3748550) /Source="Nicolas_upshift_promotors" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3748558) /Source="Nicolas_upshifts" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" CDS complement(3749612..3751057) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrous ion permease" /protein_id="NP_391707.2" /db_xref="EnsemblGenomes-Gn:BSU38280" /db_xref="EnsemblGenomes-Tr:CAB15854" /db_xref="GOA:P39595" /db_xref="InterPro:IPR004923" /db_xref="SubtiList:BG10573" /db_xref="UniProtKB/Swiss-Prot:P39595" /translation="MARGLALILFSLLMVFGSAAHAEDDPIAALIQLNKQMIKSVKDG DMDSAQQTFDTFKAKWKKEEPSIKKENLSSHSEMDANIAMISLSFINQDARKLKTQLE ELASHLETYQQAVVLKKTSSGQSRASLTAYIQSLKDTKQFIEKKQLDEASSAIDNLVT SWLAVEGDVVSQSKEAYTTSEENLALMKAEIGSHPEKVSKQIDEMIQLLEPIASSSYS WWDAALIPVREGMEALLVIGALLTMTKKARVTRSSTWIWGGASAGMAVSLAAGIGVTV LFSSSVFGENNFLLGGVTGVLSAVMLLYVGVWLHRNASMDKWREKINIQKSQALKKRS LLSFALIAFLAVVREGLETVIFFIGLVGKLPLTELIGGTAAGLIVLVIVGVLMIKLGM RIPLKPFFLLSMAVVLYMCVKFLGTGVHSLQLAGILPSDAESWLPSVSVLGIYPSVYS TIPQMLILLFLLIALVSEAAKHFTNGKELTK*" gene complement(3749612..3751057) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" promotor_-10 complement(3751091..3751110) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3751101) /Source="Nicolas_upshifts" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" promotor_-35 complement(3751124..3751131) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3751214..3751882) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" /EC_number="2.5.1.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10382260, 16291685, 19888457, 22616866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-phosphate pyrophosphorylase (thiamine phosphate synthase)" /protein_id="NP_391708.1" /db_xref="EnsemblGenomes-Gn:BSU38290" /db_xref="EnsemblGenomes-Tr:CAB15855" /db_xref="GOA:P39594" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR034291" /db_xref="InterPro:IPR036206" /db_xref="PDB:1G4E" /db_xref="PDB:1G4P" /db_xref="PDB:1G4S" /db_xref="PDB:1G4T" /db_xref="PDB:1G67" /db_xref="PDB:1G69" /db_xref="PDB:1G6C" /db_xref="PDB:2TPS" /db_xref="PDB:3O15" /db_xref="PDB:3O16" /db_xref="SubtiList:BG10572" /db_xref="UniProtKB/Swiss-Prot:P39594" /translation="MTRISREMMKELLSVYFIMGSNNTKADPVTVVQKALKGGATLYQ FREKGGDALTGEARIKFAEKAQAACREAGVPFIVNDDVELALNLKADGIHIGQEDANA KEVRAAIGDMILGVSAHTMSEVKQAEEDGADYVGLGPIYPTETKKDTRAVQGVSLIEA VRRQGISIPIVGIGGITIDNAAPVIQAGADGVSMISAISQAEDPESAARKFREEIQTY KTGR*" gene complement(3751214..3751882) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" downshifts complement(3751223) /Source="Nicolas_upshifts" /id="D1982" /incds=0 /nref=44 /ntot=194 /MaxReadThrough="1.62789" /MaxDrop="4.13196" /score="10.8502035" /energy="-10" /TU="NA" /idTUdmin="U3013" /TUdmin=0 /isTUend="TRUE" CDS complement(3751879..3752697) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" /EC_number="2.7.1.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10382260, 16291685, 22938038, 28729425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10382260, 16291685, 22938038, 28729425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-(2-hydroxyethyl)-4-methylthiazole kinase" /protein_id="NP_391709.1" /db_xref="EnsemblGenomes-Gn:BSU38300" /db_xref="EnsemblGenomes-Tr:CAB15856" /db_xref="GOA:P39593" /db_xref="InterPro:IPR000417" /db_xref="InterPro:IPR029056" /db_xref="PDB:1C3Q" /db_xref="PDB:1EKK" /db_xref="PDB:1EKQ" /db_xref="PDB:1ESJ" /db_xref="PDB:1ESQ" /db_xref="SubtiList:BG10571" /db_xref="UniProtKB/Swiss-Prot:P39593" /translation="MDAQSAAKCLTAVRRHSPLVHSITNNVVTNFTANGLLALGASPV MAYAKEEVADMAKIAGALVLNIGTLSKESVEAMIIAGKSANEHGVPVILDPVGAGATP FRTESARDIIREVRLAAIRGNAAEIAHTVGVTDWLIKGVDAGEGGGDIIRLAQQAAQK LNTVIAITGEVDVIADTSHVYTLHNGHKLLTKVTGAGCLLTSVVGAFCAVEENPLFAA IAAISSYGVAAQLAAQQTADKGPGSFQIELLNKLSTVTEQDVQEWATIERVTVS*" gene complement(3751879..3752697) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" CDS complement(3752705..3753610) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23504016; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family, cidAB expression)" /protein_id="NP_391710.1" /db_xref="EnsemblGenomes-Gn:BSU38310" /db_xref="EnsemblGenomes-Tr:CAB15857" /db_xref="GOA:P39592" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10570" /db_xref="UniProtKB/Swiss-Prot:P39592" /translation="MDIRHLTYFLEVARLKSFTKASQSLYVSQPTISKMIKNLEEELG IELFYRNGRQVELTDAGHSMYVQAQEIIKSFQNLTSELNDIMEVKKGHVRIGLPPMIG SGFFPRVLGDFRENYPNVTFQLVEDGSIKVQEGVGDGSLDIGVVVLPANEDIFHSFTI VKETLMLVVHPSHRLADEKECQLRELKDEPFIFFREDFVLHNRIMTECIKAGFRPHII YETSQWDFISEMVSANLGIGLLPERICRGLDPEKVKVIPLVDPVIPWHLAIIWRKDRY LSFAARAWLEHTKSYLWDPKKDSKG*" gene complement(3752705..3753610) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" misc_feature complement(3753345..3753364) /Source="Nicolas_upshift_promotors" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3753356) /Source="Nicolas_upshifts" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" promotor_-10 complement(3753651..3753670) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3753661..3753668 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3753672) /Source="Nicolas_upshifts" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" upshifts 3753680 /Source="Nicolas_upshifts" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" promotor_-10 3753682..3753701 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3753686..3753693) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3753716..3754102 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 22383849, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator of murein hydrolases" /protein_id="NP_391711.1" /db_xref="EnsemblGenomes-Gn:BSU38320" /db_xref="EnsemblGenomes-Tr:CAB15858" /db_xref="GOA:P39591" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023760" /db_xref="SubtiList:BG10569" /db_xref="UniProtKB/Swiss-Prot:P39591" /translation="MKKLLLTVIQIALLFIFARLINWVTALLHINIPGSIIGIVILFT LLHFNIIKLEWIELGAAWLLGELLLFFIPSAVGVIEYGDIMSKFGVSILLVVIISTFV VMVSTGTLTQLIAKRKEKKHTCSSEL*" gene 3753716..3754102 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" CDS 3754084..3754761 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator controlling activity of murein hydrolases" /protein_id="NP_391712.2" /db_xref="EnsemblGenomes-Gn:BSU38330" /db_xref="EnsemblGenomes-Tr:CAB15859" /db_xref="GOA:P39590" /db_xref="InterPro:IPR005261" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG10568" /db_xref="UniProtKB/Swiss-Prot:P39590" /translation="MFIGIVSLFLTVLVYLGAKKVYQRFPRVYTSPLLVTPAVLVGLL LLVNVPYESYNLGGGLLTDMLQPATVAFAIPLYKYFPVLKKYAVEIILNVAVGSCIAI ISTALIAKWLHLGTGLIDSLVPRSVTTPIAMNVSEMIGGMPAVTAVFVILTALLGTVI GPMVIRYFRIDNEIARGVLLGTSAHGAGTSKAFELSSVSGTISSVSMILAAIMTLCAA PFLLSFM*" gene 3754084..3754761 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" downshifts 3754733 /Source="Nicolas_upshifts" /id="D1983" /incds=0 /nref=13 /ntot=88 /MaxReadThrough="2.20109" /MaxDrop="4.23919" /score="27.0474383" /energy="-8" /TU="NA" /idTUdmin="U3015" /TUdmin=0 /isTUend="TRUE" promotor_-35 3754805..3754812 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3754823 /Source="Nicolas_upshifts" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" promotor_-10 3754826..3754845 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3754865..3756064 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar permease" /protein_id="NP_391713.1" /db_xref="EnsemblGenomes-Gn:BSU38340" /db_xref="EnsemblGenomes-Tr:CAB15860" /db_xref="GOA:P39589" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024989" /db_xref="InterPro:IPR026032" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10567" /db_xref="UniProtKB/Swiss-Prot:P39589" /translation="MHNLQVRRHYAALKGFYLFAFLGTGSIIPLLSMYLTKEQHLSGS QVGLIMSLGPIVMIFFQPFWGMLSDYTQKTKGLLAVCTSITGIIGLAYIAFDSFPLFI LIAACFAAFQSTIIPLSDSISLRYTQETNGNYGGIRLFGSLGFGVAVFAMGQVTNQLY PIHVIFIFGCAFLCIAAILASQVPGQQKTTKVNIRKGFRELISNKTFLIFMIITFTTF APNLANNTYFSLFLDKSGASLSAIGILFFIGVISEIPFMRFAQTFIDKMGLLNVIMLS GGVSLFRWALYFTAPSLWIIYATVFLQGVAIGLFIPAALQYVKKITPRHVEATALTMY AAIGNGFGNWFCTFAGGYIFDYVSIFAVYLLFGILSIAGFGLTLYLMKAEKNKHTLHQ PAVTFKP*" gene 3754865..3756064 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" CDS 3756098..3756295 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391714.1" /db_xref="EnsemblGenomes-Gn:BSU38350" /db_xref="EnsemblGenomes-Tr:CAB15861" /db_xref="InterPro:IPR019240" /db_xref="SubtiList:BG10566" /db_xref="UniProtKB/Swiss-Prot:P39588" /translation="MNGQERNSISKGLQVDIVLKADQKTGKLTRGTVKDILTKSNFHP HGIKVRLEDGRIGRDQQIVST*" gene 3756098..3756295 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" downshifts 3756274 /Source="Nicolas_upshifts" /id="D1984" /incds=0 /nref=15 /ntot=205 /MaxReadThrough="1.90583" /MaxDrop="4.20528" /score="21.8132292" /energy="-12.2" /TU="NA" /idTUdmin="U3016" /TUdmin=88 /isTUend="FALSE" CDS complement(3756331..3757521) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18786544, 18789337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="large subunit ribosomal RNA m5C1962 methyltransferase" /protein_id="NP_391715.1" /db_xref="EnsemblGenomes-Gn:BSU38360" /db_xref="EnsemblGenomes-Tr:CAB15862" /db_xref="GOA:P39587" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019614" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10565" /db_xref="UniProtKB/Swiss-Prot:P39587" /translation="MKLLTLKKAHAAKIKKGYPLIEKEALAGSAGHMKEGDLVDIVSE SGGEFLARGYYGLQNKGVGWTLTRNKHEQIDQAFFLSKLTKAAQARAKLFEAQDTTAF RLFNGEGDGVGGVTIDYYDGYLLIQWYSKGIYTFKDMLISALDEMDLDYKAIYEKKRF DTAGQYVEDDDFVKGRRGEFPIIIQENGIQYAVDLNEGAMTGIFLDQRHVRKAIRDRY AKGKTVLNTFSYTGAFSVAAALGGAEKTTSVDVANRSLAKTIEQFSVNKLDYEAHDIK VMDVFNYFSYAAKKDLRFDLIILDPPSFARTKKRTFSAAKDYKNLLKETIAITADKGV IVASTNSSAFGMKKFKGFIDAAFKETNERYTIIEEFTLPEDFKTISAFPEGNYLKVVL LQKK*" gene complement(3756331..3757521) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" downshifts complement(3756346) /Source="Nicolas_upshifts" /id="D1985" /incds=0 /nref=5 /ntot=127 /MaxReadThrough="0.0525399999999996" /MaxDrop="4.51664" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin=71 /isTUend="FALSE" downshifts complement(3756430) /Source="Nicolas_upshifts" /id="D1986" /incds=1 /nref=42 /ntot=233 /MaxReadThrough="2.99734" /MaxDrop="3.89369" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin="-13" /isTUend="TRUE" misc_feature complement(3757545..3757564) /Source="Nicolas_upshift_promotors" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3757561) /Source="Nicolas_upshifts" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" promotor_-35 3757581..3757588 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3757597 /Source="Nicolas_upshifts" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" promotor_-10 3757602..3757621 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3757642..3758022 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:24330391, 25283443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391, 25283443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase I; hemithioacetal-bacillithiol lactoyl-bacillithiol formation" /protein_id="NP_391716.1" /db_xref="EnsemblGenomes-Gn:BSU38370" /db_xref="EnsemblGenomes-Tr:CAB15863" /db_xref="GOA:P39586" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10564" /db_xref="UniProtKB/Swiss-Prot:P39586" /translation="MAKRIDHTGIMVRDINASITFYEEVLGMKLKDRITHTNGVIELA FLGFEDGPETEIELIQGYSSELPAEGKVHHIALLTDDIAAEYTKAEKMNAKFIDEEIT TLPNGYRYFYIEGPDGEWIEFFQR*" gene 3757642..3758022 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" downshifts 3757920 /Source="Nicolas_upshifts" /id="D1987" /incds=1 /nref=14 /ntot=215 /MaxReadThrough="3.76076" /MaxDrop="3.68951" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-357" /isTUend="FALSE" downshifts 3757991 /Source="Nicolas_upshifts" /id="D1988" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="3.05249" /MaxDrop="3.56101" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-286" /isTUend="FALSE" CDS complement(3758060..3758737) /gene="ywbB" /locus_tag="BSU_38380" /old_locus_tag="BSU38380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391717.1" /db_xref="EnsemblGenomes-Gn:BSU38380" /db_xref="EnsemblGenomes-Tr:CAB15864" /db_xref="InterPro:IPR024250" /db_xref="SubtiList:BG10563" /db_xref="UniProtKB/Swiss-Prot:P39585" /translation="MLDYIWLDDESPILQQVPVEYSSAALIFSPFIQMPEGWENAKRK NDYEHIYPNDNEIRGIGKAVSWKKVMSSCGFQTHAELALALMTSIGALRDEFAREDLA EVLHENINGDLYYPSEDHISNFHIPSLVKVLGANGSNRFYYAEPIVENRGVLDITEAN LRTVLDEAATELVLTDEKMDFVFMSVYDSFINVFLAKDKNIHELVERMGWEAMICDES TYISWYR*" gene complement(3758060..3758737) /gene="ywbB" /locus_tag="BSU_38380" /old_locus_tag="BSU38380" downshifts complement(3758067) /Source="Nicolas_upshifts" /id="D1989" /incds=0 /nref=6 /ntot=156 /MaxReadThrough="0.15283" /MaxDrop="5.41362" /score="0.491291944" /energy="-11.7" /TU="NA" /idTUdmin="U3020" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3758746..3758765) /Source="Nicolas_upshift_promotors" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3758771) /Source="Nicolas_upshifts" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" promotor_-35 complement(3758777..3758783) /Source="Nicolas_upshift_promotors" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3758814..3760148) /gene="ywbA" /locus_tag="BSU_38390" /old_locus_tag="BSU38390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8990303, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cellobiose phosphotransferase system enzyme IIC permease component" /protein_id="NP_391718.1" /db_xref="EnsemblGenomes-Gn:BSU38390" /db_xref="EnsemblGenomes-Tr:CAB15865" /db_xref="GOA:P39584" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG10562" /db_xref="UniProtKB/Swiss-Prot:P39584" /translation="MSTFTRVMEEKIMPVAGKIAGQRHLSALRDGIILTMPLIIIGSV FLILTSLPIPGYADFMASVFGNEWADKLGYPVNASFDIMAMIAAFGIAYRLAESYGVD ALSAGAISIAAFLLATPFEVPFTPHGSTESIMVGGGIPITLLGSKGLFVAMLIALFST EIYRYIIQKNIVFKMPDGVPPAVSKSFVALIPGFIIVLLVWLARLLIEMTPFQSLHNV VGDLLGTPLSILGGSLGGSLIAEFVQMLLWSCGIHGASIIGGIMAPIWYGAMDANRLA FQAGEALPSIFTTQFFQIWINVGGSGATLALVLTMLVRSRSKQMKQLGRLGIGPALFN INEPIIFGMPIVMNPLLIVPFIIAPLLTITATYIGMSTGLVARPAGIAVPWTMPPLIS GYLATGGKVSGAVMQLVNLLITCAIYYPFFRIWDHQKWREESAVESGDKNVM*" gene complement(3758814..3760148) /gene="ywbA" /locus_tag="BSU_38390" /old_locus_tag="BSU38390" misc_feature complement(3760196..3760214) /Source="Nicolas_upshift_promotors" /id="U3020" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.596403596403596" /psig="0.596403596403596" /xcortree=1254 /SigmaFactorBS="tttagcaaaatgcagattttttccgcatgaagaggaaatttt ccaaatgaatttgtaagcgttttCAAAATAAGATAAAGAAAAcattgcggaggttgtt c" /listShort="ywbA, ywbB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3760219) /Source="Nicolas_upshifts" /id="U3020" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.596403596403596" /psig="0.596403596403596" /xcortree=1254 /SigmaFactorBS="tttagcaaaatgcagattttttccgcatgaagaggaaatttt ccaaatgaatttgtaagcgttttCAAAATAAGATAAAGAAAAcattgcggaggttgtt c" /listShort="ywbA, ywbB" /GFF_Attribute="listLong" promotor_-35 3760313..3760320 /Source="Nicolas_upshift_promotors" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3760325 /Source="Nicolas_upshifts" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" promotor_-10 3760334..3760352 /Source="Nicolas_upshift_promotors" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3760376..3762313 /gene="epr" /locus_tag="BSU_38400" /old_locus_tag="BSU38400" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1938892, 2116590, 16553828, 17666034, 19416356, 23660663, 25966269" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1938892, 2116590, 16553828, 17666034, 19416356, 23660663, 25966269; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular serine protease" /protein_id="NP_391719.1" /db_xref="EnsemblGenomes-Gn:BSU38400" /db_xref="EnsemblGenomes-Tr:CAB15866" /db_xref="GOA:P16396" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR009020" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="SubtiList:BG10561" /db_xref="UniProtKB/Swiss-Prot:P16396" /translation="MKNMSCKLVVSVTLFFSFLTIGPLAHAQNSSEKEVIVVYKNKAG KETILDSDADVEQQYKHLPAVAVTADQETVKELKQDPDILYVENNVSFTAADSTDFKV LSDGTDTSDNFEQWNLEPIQVKQAWKAGLTGKNIKIAVIDSGISPHDDLSIAGGYSAV SYTSSYKDDNGHGTHVAGIIGAKHNGYGIDGIAPEAQIYAVKALDQNGSGDLQSLLQG IDWSIANRMDIVNMSLGTTSDSKILHDAVNKAYEQGVLLVAASGNDGNGKPVNYPAAY SSVVAVSATNEKNQLASFSTTGDEVEFSAPGTNITSTYLNQYYATGSGTSQATPHAAA MFALLKQRDPAETNVQLREEMRKNIVDLGTAGRDQQFGYGLIQYKAQATDSAYAAAEQ AVKKAEQTKAQIDINKARELISQLPNSDAKTALHKRLDKVQSYRNVKDAKDKVAKAEK YKTQQTVDTAQTAINKLPNGTDKKNLQKRLDQVKRYIASKQAKDKVAKAEKSKKKTDV DSAQSAIGKLPASSEKTSLQKRLNKVKSTNLKTAQQSVSAAEKKSTDANAAKAQSAVN QLQAGKDKTALQKRLDKVKKKVAAAEAKKVETAKAKVKKAEKDKTKKSKTSAQSAVNQ LKASNEKTKLQKRLNAVKPKK*" gene 3760376..3762313 /gene="epr" /locus_tag="BSU_38400" /old_locus_tag="BSU38400" promotor_-10 complement(3761520..3761539) /Source="Nicolas_upshift_promotors" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3761521) /Source="Nicolas_upshifts" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3761553..3761561) /Source="Nicolas_upshift_promotors" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3762303 /Source="Nicolas_upshifts" /id="D1990" /incds=0 /nref=175 /ntot=224 /MaxReadThrough="1.26567" /MaxDrop="6.00181" /score="15.6173594" /energy="-13" /TU="NA" /idTUdmin="U3021" /TUdmin=0 /isTUend="TRUE" promotor_-35 3762416..3762423 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3762438..3762457 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3762457 /Source="Nicolas_upshifts" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 3762669..3762676 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3762689..3762708 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3762689 /Source="Nicolas_upshifts" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" CDS 3762741..3764120 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11580842, 1400159, 8535520, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11580842, 1400159, 8535520, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of SacY" /protein_id="NP_391720.1" /db_xref="EnsemblGenomes-Gn:BSU38410" /db_xref="EnsemblGenomes-Tr:CAB15867" /db_xref="GOA:P15400" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10560" /db_xref="UniProtKB/Swiss-Prot:P15400" /translation="MHKEIAKELLLLAGGKNNIISISHCTTRLRFDVKDETKIDIHAI ENLQGVQGTFFRYGLFQIIFGAGVVNKIYKEVVHVWETAPSEEPVHQKKASRKLNPAA AFAKTLSDIFVPIIPAITASGLLMGLIGMIKVFHWFAAGSPWIKMLDLVSSTAFILLP ILVGFSAARQFGSNPYLGAVIAGLLTHPDLLDPSMLGSKTPSSLDIWGLHIPMMGYQG SMIPILLSVFVMSKIEKLLKSIVPKSLDVVIIPFITVMVTGCLALIVMNPAASIIGQI MTQSIVYIYDHAGIAAGALFGGIYSTIVLSGLHHSFYAIEATLLANPHVGVNFLVPIW SMANVAQGGAGLAVFLKTKQSSLKKIALPASLTAFLGIVEPIVFGVNLKLIRPFIGAA IGGAIGGAYVVAVQVVANSYGLTGIPMISIVLPFGAANFVHYMIGFLIAAVSAFIATL FLGFKEETE*" gene 3762741..3764120 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" S_feature complement(3763829..3765032) /Source="Nicolas_S_feature" /locus_tag="new_3943322_3944525_c" /HighExp="Etha, B36, B60, M9-stat, Salt, Sw, LoTm, C30, Gly, Heat" /AntisenseName="sacY" /AntisenseCor="-0.177403958488455" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1477" CDS 3764174..3765016 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9305644, 9457872, 11580842, 12079345, 15528654, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9305644, 9457872, 11580842, 12079345, 15528654, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391721.1" /db_xref="EnsemblGenomes-Gn:BSU38420" /db_xref="EnsemblGenomes-Tr:CAB15868" /db_xref="GOA:P15401" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1AUU" /db_xref="SubtiList:BG10559" /db_xref="UniProtKB/Swiss-Prot:P15401" /translation="MKIKRILNHNAIVVKDQNEEKILLGAGIAFNKKKNDIVDPSKIE KTFIRKDTPDYKQFEEILETLPEDHIQISEQIISHAEKELNIKINERIHVAFSDHLSF AIERLSNGMVIKNPLLNEIKVLYPKEFQIGLWARALIKDKLGIHIPDDEIGNIAMHIH TARNNAGDMTQTLDITTMIRDIIEIIEIQLSINIVEDTISYERLVTHLRFAIQHIKAG ESIYELDAEMIDIIKEKFKDAFLCALSIGTFVKKEYGFEFPEKELCYIAMHIQRFYQR SVAR*" gene 3764174..3765016 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" CDS complement(3765067..3765927) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11377871, 19659723; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase (general stress protein)" /protein_id="NP_391722.1" /db_xref="EnsemblGenomes-Gn:BSU38430" /db_xref="EnsemblGenomes-Tr:CAB15869" /db_xref="GOA:P25148" /db_xref="InterPro:IPR002495" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10558" /db_xref="UniProtKB/Swiss-Prot:P25148" /translation="MRKDEIMHIVSCADDNYARHLGGMFVSLLTNMDQEREVKLYVID GGIKPDNKKRLEETTLKFGVPIEFLEVDTNMYEHAVESSHITKAAYYRISIPDLIKDE SIKRMIYIDCDALVLEDISKLWDLDIAPYTVAAVEDAGQHERLKEMNVTDTGKYFNSG IMIIDFESWRKQNITEKVINFINEHPDEDFLVLHDQDALNAILYDQWYELHPRWNAQT YIMLKLKTPSTLLGRKQYNETRENPAIVHFCGGEKPWNSNTKHPYRDEYFHYMSYTKW NTIGNPAINQ*" gene complement(3765067..3765927) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" downshifts complement(3765077) /Source="Nicolas_upshifts" /id="D1991" /incds=0 /nref=73 /ntot=227 /MaxReadThrough="5.61926" /MaxDrop="7.47527" /score="21.8603429" /energy="-10.6" /TU="U3025" /idTUdmin="U3025" /TUdmin="-1224" /isTUend="FALSE" downshifts 3765911 /Source="Nicolas_upshifts" /id="D1992" /incds=0 /nref=8 /ntot=30 /MaxReadThrough="1.49599" /MaxDrop="5.33818" /score="10.6843241" /energy="-4.5" /TU="NA" /idTUdmin="U3026" /TUdmin="-528" /isTUend="FALSE" promotor_-10 complement(3765949..3765967) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3765967) /Source="Nicolas_upshifts" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" promotor_-35 complement(3765982..3765988) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3766037..3766750) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391723.1" /db_xref="EnsemblGenomes-Gn:BSU38440" /db_xref="EnsemblGenomes-Tr:CAB15870" /db_xref="GOA:P25149" /db_xref="InterPro:IPR011737" /db_xref="SubtiList:BG10557" /db_xref="UniProtKB/Swiss-Prot:P25149" /translation="MQKYVQSDYKHDPFHLFSTEHVVTLAIISLLAILLFLFQDEVKQ PRASRFLRSLFVFLLLGSQIGYQIWMVATDRWSVRTSLPLQLSDLSVYLSAIMLVTKS RKLFVFLFFVGIGSSIQALATPDLGMFSFPHIRYILFFISHGSVFLSCLLMAVIGTYR MGQRSLWVTVLLVNVYGVCIFLIDRWLGANYMYLTKKPGGSSLLDVLGPWPWYIVSAE AITIASFFILYWLYRIFKK*" gene complement(3766037..3766750) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" promotor_-35 3766152..3766153 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3766173..3766190 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3766175 /Source="Nicolas_upshifts" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3766778..3766789) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3766779) /Source="Nicolas_upshifts" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3766804..3766810) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3766825..3766831 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3766846..3766865 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3766856 /Source="Nicolas_upshifts" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" CDS 3766901..3767416 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25733610; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling expressionof tyrZ" /protein_id="NP_391724.1" /db_xref="EnsemblGenomes-Gn:BSU38450" /db_xref="EnsemblGenomes-Tr:CAB15871" /db_xref="GOA:P25150" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10556" /db_xref="UniProtKB/Swiss-Prot:P25150" /translation="MERSHQHQQLRKEEHDTLSKLKQMPVESLNLEAISIATNLYRSA QRLRVKMETEVLSTYNLSWTAFSILYDLWVWGALETRKIAELSGISTATASNVIKTLE KKSFCRKSIDTRDRRLVFVSITDSGKQAIEELYPEFHKGETELIAGMTKDEQKILTGL LRKVADNLHTT*" gene 3766901..3767416 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" misc_RNA 3767417..3767623 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" /product="T-box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" gene 3767417..3767623 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" downshifts 3767583 /Source="Nicolas_upshifts" /id="D1993" /incds=0 /nref=15 /ntot=112 /MaxReadThrough="1.84575" /MaxDrop="4.56656" /score="23.8000948" /energy="-14.5" /TU="NA" /idTUdmin="U3028" /TUdmin=0 /isTUend="TRUE" CDS 3767665..3768906 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" /EC_number="6.1.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1735721, 1806041, 25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1735721, 1806041, 25733610; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_391725.1" /db_xref="EnsemblGenomes-Gn:BSU38460" /db_xref="EnsemblGenomes-Tr:CAB15872" /db_xref="GOA:P25151" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024108" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10555" /db_xref="UniProtKB/Swiss-Prot:P25151" /translation="MMRTFEQLTASQQKEVERQLQLYMTGAHEVIPPEELKAKLVKSI STGTPLKIKLGLDPSAPDVHLGHTVVLNKLRQFQENGHIVQLLIGDFTGKIGDPTGKS AARKQLTDEEVQHNAKTYFEQFGKVLDPEKVELHYNSKWLKTLNLEDVIELAGKITVA RLMERDDFEERIAMQKPISLHEFFYPLMQGYDSVVLESDIELGGTDQHFNVLMGRHFQ ERYNKEKQVVILMPLLEGLDGVEKMSKSKHNYIGINEHPNDMYGKTMSLPDSLMKKYI HLATDLELEEKKQLVKDLETGAVHPRDAKMLLARTIVRMYHGEKAAEAAEHSFKTVFQ ENSLPEDIPAVNWKGEKTIAMIDLLVKLKLLSSKSEARRMIQNGGVRIDGEKVTDVHA KAEIRENMIIQVGKRKFLKLQ*" gene 3767665..3768906 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" promotor_-35 3768997..3769005 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3769016..3769034 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3769027 /Source="Nicolas_upshifts" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" CDS 3769062..3770429 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15668014, 23426795, 26898926, 28257579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668014, 23426795, 26898926, 28257579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported double-zinc aminopeptidase" /protein_id="NP_391726.1" /db_xref="EnsemblGenomes-Gn:BSU38470" /db_xref="EnsemblGenomes-Tr:CAB15873" /db_xref="GOA:P25152" /db_xref="InterPro:IPR003137" /db_xref="InterPro:IPR007484" /db_xref="SubtiList:BG10554" /db_xref="UniProtKB/Swiss-Prot:P25152" /translation="MKKLLTVMTMAVLTAGTLLLPAQSVTPAAHAVQISNSERELPFK AKHAYSTISQLSEAIGPRIAGTAAEKKSALLIASSMRKLKLDVKVQRFNIPDRLEGTL SSAGRDILLQAASGSAPTEEQGLTAPLYNAGLGYQKDFTADAKGKIALISRGDLTYYE KAKNAEAAGAKAVIIYNNKESLVPMTPNLSGNKVGIPVVGIKKEDGEALTQQKEATLK LKAFTNQTSQNIIGIKKPKNIKHPDIVYVTAHYDSVPFSPGANDNGSGTSVMLEMARV LKSVPSDKEIRFIAFGAEELGLLGSSHYVDHLSEKELKRSEVNFNLDMVGTSWEKASE LYVNTLDGQSNYVWESSRTAAEKIGFDSLSLTQGGSSDHVPFHEAGIDSANFIWGDPE TEEVEPWYHTPEDSIEHISKERLQQAGDLVTAAVYEAVKKEKKPKTIKKQMKAKASDI FEDIK*" gene 3769062..3770429 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" downshifts 3770406 /Source="Nicolas_upshifts" /id="D1994" /incds=0 /nref=3 /ntot=37 /MaxReadThrough="1.38814" /MaxDrop="6.05871" /score="27.7635079" /energy="-13.3" /TU="NA" /idTUdmin="U3029" /TUdmin=7 /isTUend="TRUE" CDS complement(3770459..3771091) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" /EC_number="2.7.6.5" /function="16.7: Manage energy" /function="16.3: Control" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_391727.1" /db_xref="EnsemblGenomes-Gn:BSU38480" /db_xref="EnsemblGenomes-Tr:CAB15874" /db_xref="GOA:P39583" /db_xref="InterPro:IPR007685" /db_xref="SubtiList:BG10553" /db_xref="UniProtKB/Swiss-Prot:P39583" /translation="MDLSVTHMDDLKTVMEDWKNELLVYKFALDALDTKFSIISQEYN LIHGHNPIEHTKSRVKSFESIVNKLMRKGCEITTKEMKEHIHDIAGVRIICSFISDIY NVVNVLKQHEDLRIVKVKDYIQTPKPNGYRSLHLIIEMPVNLTNRVEYVKAEIQIRTI AMDFWASLEHKIYYKLNNDVPKQLTDELKEAAEIAHYLDEKMLGIKKEVD*" gene complement(3770459..3771091) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" downshifts complement(3770477) /Source="Nicolas_upshifts" /id="D1995" /incds=0 /nref=200 /ntot=257 /MaxReadThrough="2.49976" /MaxDrop="5.49802" /score="47.236042" /energy="-13.3" /TU="NA" /idTUdmin="U3030" /TUdmin="-2" /isTUend="TRUE" promotor_-10 complement(3771127..3771142) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3771135) /Source="Nicolas_upshifts" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" promotor_-35 complement(3771155..3771163) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3771233..3772168) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" /EC_number="2.5.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6780514, 9573170, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-dihydroxy-2-naphthoate octaprenyltransferase" /protein_id="NP_391728.1" /db_xref="EnsemblGenomes-Gn:BSU38490" /db_xref="EnsemblGenomes-Tr:CAB15875" /db_xref="GOA:P39582" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR004657" /db_xref="InterPro:IPR026046" /db_xref="SubtiList:BG10552" /db_xref="UniProtKB/Swiss-Prot:P39582" /translation="MNQTNKGEGQTAPQKESMGQILWQLTRPHTLTASFVPVLLGTVL AMFYVKVDLLLFLAMLFSCLWIQIATNLFNEYYDFKRGLDTAESVGIGGAIVRHGMKP KTILQLALASYGIAILLGVYICASSSWWLALIGLVGMAIGYLYTGGPLPIAYTPFGEL FSGICMGSVFVLISFFIQTDKINMQSILISIPIAILVGAINLSNNIRDIEEDKKGGRK TLAILMGHKGAVTLLAASFAVAYIWVVGLVITGAASPWLFVVFLSVPKPVQAVKGFVQ NEMPMNMIVAMKSTAQTNTFFGFLLSIGLLISYFR*" gene complement(3771233..3772168) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" downshifts complement(3771245) /Source="Nicolas_upshifts" /id="D1996" /incds=0 /nref=10 /ntot=113 /MaxReadThrough="3.08081" /MaxDrop="4.6874" /score="16.8971767" /energy="-8.5" /TU="NA" /idTUdmin="U3032" /TUdmin=0 /isTUend="TRUE" promotor_-35 3771912..3771921 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3771935..3771954 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3771939 /Source="Nicolas_upshifts" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(3772169..3772256) /Source="Nicolas_S_feature" /locus_tag="new_3951662_3951749_c" /HighExp="LBGstat, Paraq, G180, LBGexp, G135, Oxctl, C30, Cold, Diami, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.81271400000000005" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.498" /TUlongSig="NA" /TUlongPSig="NA" /label="S1478" promotor_-10 complement(3772239..3772258) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3772256) /Source="Nicolas_upshifts" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" promotor_-35 complement(3772274..3772278) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3772301..3772313) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3772301) /Source="Nicolas_upshifts" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" promotor_-35 complement(3772328..3772334) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3772331..3772465) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514012.1" /translation="MECFELIHNKGKDTWSQKIFLTFKKCNVLKKIFLYLFVQVKAET *" gene complement(3772331..3772465) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" promotor_-35 3772412..3772419 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-35" promotor_-10 3772433..3772452 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-10" upshifts 3772442 /Source="Nicolas_upshifts" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" S_feature 3772445..3772549 /Source="Nicolas_S_feature" /locus_tag="new_3951938_3952042" /HighExp="H2O2, Paraq, Oxctl, G180, G150, C30, G135, LBGstat, dia15, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1479" promotor_-35 3772544..3772553 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3772551 /Source="Nicolas_upshifts" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" promotor_-10 3772565..3772580 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3772587) /Source="Nicolas_upshifts" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(3772589..3772603) /Source="Nicolas_upshift_promotors" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3772615..3772764 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical membrane protein" /protein_id="YP_003097795.1" /db_xref="EnsemblGenomes-Gn:BSU38499" /db_xref="EnsemblGenomes-Tr:CAX52708" /db_xref="GOA:C0H3T3" /db_xref="InterPro:IPR021008" /db_xref="UniProtKB/Swiss-Prot:C0H3T3" /translation="MLQLMKQLYEKPAVKWTCHTGFYLMILLVLFFMYGFHTANTGSY IYNDF*" gene 3772615..3772764 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" CDS 3772782..3774293 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" /EC_number="6.1.1.13" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine:D-alanyl-carrier protein ligase subunit" /protein_id="NP_391729.1" /db_xref="EnsemblGenomes-Gn:BSU38500" /db_xref="EnsemblGenomes-Tr:CAB15876" /db_xref="GOA:P39581" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR010072" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:3E7W" /db_xref="PDB:3E7X" /db_xref="SubtiList:BG10551" /db_xref="UniProtKB/Swiss-Prot:P39581" /translation="MKLLHAIQTHAETYPQTDAFRSQGQSLTYQELWEQSDRAAAAIQ KRISGEKKSPILVYGHMEPHMIVSFLGSVKAGHPYIPVDLSIPSERIAKIIESSGAEL LIHAAGLSIDAVGQQIQTVSAEELLENEGGSVSQDQWVKEHETFYIIYTSGSTGNPKG VQISAANLQSFTDWICADFPVSGGKIFLNQAPFSFDLSVMDLYPCLQSGGTLHCVTKD AVNKPKVLFEELKKSGLNVWTSTPSFVQMCLMDPGFSQDLLPHADTFMFCGEVLPVSV AKALLERFPKAKIFNTYGPTEATVAVTSVEITNDVISRSESLPVGFAKPDMNIFIMDE EGQPLPEGEKGEIVIAGPSVSRGYLGEPELTEKAFFSHEGQWAYRTGDAGFIQDGQIF CQGRLDFQIKLHGYRMELEEIEFHVRQSQYVRSAVVIPYQPNGTVEYLIAAIVPEEHE FEKEFQLTSAIKKELAASLPAYMIPRKFIYQDHIQMTANGKIDRKRIGEEVLV*" gene 3772782..3774293 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" CDS 3774290..3775477 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 15849754, 16850406, 17263852; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine transferase from DCP to undecaprenylphosphate for lipoteichoic acid and wall teichoic acid" /protein_id="NP_391730.1" /db_xref="EnsemblGenomes-Gn:BSU38510" /db_xref="EnsemblGenomes-Tr:CAB15877" /db_xref="GOA:P39580" /db_xref="InterPro:IPR004299" /db_xref="InterPro:IPR024024" /db_xref="InterPro:IPR024194" /db_xref="SubtiList:BG10550" /db_xref="UniProtKB/Swiss-Prot:P39580" /translation="MTPYSSFLFFILLGILLLPTIILGLNGKRFQAYNMFISIIILAL IFSHDLHGVIALCLFTIWQVLLISGYLAYRQKANSGFVFCGAVIASILPLFLSKIWPF LSHPQPHHPPHNLISFLGISYLTFKGVQLIMEARDGLLKEQLPLHRLLYFILFFPTIS SGPIDRYRRFVKDEQKAWTKEEYADLLYTGIHKIFIGFLYKFIIGYAINTYFIMNLPA ITHNKILGNLLYMYGYSMYLFFDFAGYTMFAVGVSYIMGIKSPENFNKPFISKNIKDF WNRWHMSLSFWFRDYVFMRFVFWMTKKKWIKNRMAVSNIGYFLLFMLMGVWHGLAPQY IIYGLYHAVLMTCYNFFEKWNKKYKWLPSNRWTTILAIVITFHFVCFGFYIFSGKPFH HHH*" gene 3774290..3775477 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" CDS 3775494..3775730 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 26193422" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 26193422; Product type c: carrier" /codon_start=1 /transl_table=11 /product="D-alanyl carrier protein" /protein_id="NP_391731.1" /db_xref="EnsemblGenomes-Gn:BSU38520" /db_xref="EnsemblGenomes-Tr:CAB15878" /db_xref="GOA:P39579" /db_xref="InterPro:IPR003230" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:4BPF" /db_xref="PDB:4BPG" /db_xref="PDB:4BPH" /db_xref="SubtiList:BG10549" /db_xref="UniProtKB/Swiss-Prot:P39579" /translation="MDFKQEVLDVLAEVCQDDIVKENPDIEIFEEGLLDSFGTVELLL AIENRFDILVPITEFDRDVWNTPNNIVNQLSELK*" gene 3775494..3775730 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" CDS 3775730..3776908 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 17263852, 17600057, 23858088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine from undecaprenylphosphate tothe polyglycerolphosphate chain for lipoteichoic acid andwall teichoic acid synthesis" /protein_id="NP_391732.1" /db_xref="EnsemblGenomes-Gn:BSU38530" /db_xref="EnsemblGenomes-Tr:CAB15879" /db_xref="GOA:P39578" /db_xref="InterPro:IPR006998" /db_xref="InterPro:IPR023896" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG10548" /db_xref="UniProtKB/Swiss-Prot:P39578" /translation="MKKRFFGPIILAFILFAGAIAIPSSWLTGFITDKRVKESATALN PSMFQGLYLQDQMLKDPTYLPIYGSSELSRLDEFHPSNYFQVNNEGFTPYLVGKGGSQ SLIHSLNFAAHMDQLKGKKIVFIVSPQWFIKRGSDEQHFAPNYSALQGLDLAFNDQID PEIKKKMMKRMLRFKAVQNDAILSELYKAMVNGQTWKVNALKPAAKVYYSMLEKKDLY YSTTESSGPKRYISQSVKDKSWSELNKLADQSGKRHSGSNDFHIDNPVYKKLKPKVPK LKGKNKGRSYAVSPEYGDFEMMLDILKDAGAEPMFVTIPVNGKWYDYTGFPKKGRTDY YKKVNKQIRAKGFQVADFSGHEYDPYFMKDTIHIGWKGWVYVDKAIDEFYKTGKVTSS *" gene 3775730..3776908 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" S_feature 3776909..3776998 /Source="Nicolas_S_feature" /locus_tag="new_3956402_3956491" /HighExp="Paraq, H2O2, Oxctl, LBGexp, Lbexp, dia0, C30, Cold, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1480" CDS 3776999..3777757 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7797557, 14665680; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391733.2" /db_xref="EnsemblGenomes-Gn:BSU38540" /db_xref="EnsemblGenomes-Tr:CAB15880" /db_xref="GOA:P39577" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10547" /db_xref="UniProtKB/Swiss-Prot:P39577" /translation="MKMTNNTVLITGGSAGIGLELAKRLLELGNEVIICGRSEARLAE AKQQLPNIHTKQCDVADRSQREALYEWALKEYPNLNVLVNNAGIQKEIDFKKGTEELF VDGDEIELNFQAPVHLSALFTPHLMKQPEAAIVQVTSGLAFNPLAVYPVYCATKAALH SFSLTLRHQLRDTSVEVIEMAPPMVDTGLNQKSRDKQGLTYRGISSEEYVQYFLDGLK EGKQEITNERVEGLRDATRADYDRLFEQMNTQEN*" gene 3776999..3777757 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" downshifts 3777725 /Source="Nicolas_upshifts" /id="D1997" /incds=0 /nref=48 /ntot=172 /MaxReadThrough="5.94016" /MaxDrop="4.72547" /score="22.6844301" /energy="-13.7" /TU="U3035" /idTUdmin="U3035" /TUdmin="-1254" /isTUend="FALSE" S_feature complement(3777759..3778986) /Source="Nicolas_S_feature" /locus_tag="new_3957252_3958479_c" /HighExp="T0.30H, T1.0H, T1.30H, C30, B60, T2.0H, C90, Gly, T2.30H, S8" /AntisenseName="ilvK" /AntisenseCor="-0.12928749136401099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1481" promotor_-35 3777805..3777812 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3777826..3777845 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3777839 /Source="Nicolas_upshifts" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" CDS 3777898..3778989 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 17611193, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 17611193, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid aminotransferase" /protein_id="NP_391734.2" /db_xref="EnsemblGenomes-Gn:BSU38550" /db_xref="EnsemblGenomes-Tr:CAB15881" /db_xref="GOA:P39576" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10546" /db_xref="UniProtKB/Swiss-Prot:P39576" /translation="MTKQTIRVELTSTKKPKPDPNQLSFGRVFTDHMFVMDYAADKGW YDPRIIPYQPLSMDPAAMVYHYGQTVFEGLKAYVSEDDHVLLFRPEKNMERLNQSNDR LCIPQIDEEQVLEGLKQLVAIDKDWIPNAEGTSLYIRPFIIATEPFLGVAASHTYKLL IILSPVGSYYKEGIKPVKIAVESEFVRAVKGGTGNAKTAGNYASSLKAQQVAEEKGFS QVLWLDGIEKKYIEEVGSMNIFFKINGEIVTPMLNGSILEGITRNSVIALLKHWGLQV SERKIAIDEVIQAHKDGILEEAFGTGTAAVISPVGELIWQDETLSINNGETGEIAKKL YDTITGIQKGAVADEFGWTTEVAALTESK*" gene 3777898..3778989 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" downshifts 3778891 /Source="Nicolas_upshifts" /id="D1998" /incds=1 /nref=10 /ntot=90 /MaxReadThrough="6.0829" /MaxDrop="3.1965" /score="32.8755878" /energy="-13.6" /TU="U3035,U3037" /idTUdmin="U3035" /TUdmin="-88" /isTUend="FALSE" downshifts 3778979 /Source="Nicolas_upshifts" /id="D1999" /incds=0 /nref=157 /ntot=264 /MaxReadThrough="2.21106" /MaxDrop="6.83094" /score="32.8755878" /energy="-13.6" /TU="NA" /idTUdmin="U3035" /TUdmin=0 /isTUend="TRUE" CDS complement(3779023..3780351) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8990303, 10438772, 22720735, 23874669, 24673833; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-beta-glucosidase" /protein_id="NP_391735.1" /db_xref="EnsemblGenomes-Gn:BSU38560" /db_xref="EnsemblGenomes-Tr:CAB15882" /db_xref="GOA:P46320" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11350" /db_xref="UniProtKB/Swiss-Prot:P46320" /translation="MTKGLKIVTIGGGSSYTPELVEGFIKRYDELPVRELWLVDIPEG EEKLNIVGTLAKRMVEKAGVPIDIHLTLDRRKALKDADFVTTQFRVGLLQARAKDERI PLKYGVIGQETNGPGGLFKGLRTIPVILEIAKDIEELCPNAWLVNFTNPAGMVTEALL RYSNLKKVVGLCNVPIGIKMGVAKALDVDVDRVEVQFAGLNHMVFGLDVFLDGVSVKE QVIEAMGDPKNAMTMKNISGAEWEPDFLKALNVIPCGYHRYYFKTKEMLEHELEASQT EGTRAEVVQKVEKELFELYKDPNLAIKPPQLEKRGGAYYSDAACNLISSIYNDKHDIQ PVNTINNGAIASIPDDSAVEVNCVMTKTGPKPIAVGDLPVSVRGLVQQIKSFERVAAE AAVTGDYQTALLAMTINPLVPSDTVAKQILDEMLEAHKAYLPQFFNKIEA*" gene complement(3779023..3780351) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" downshifts complement(3779031) /Source="Nicolas_upshifts" /id="D2000" /incds=0 /nref=12 /ntot=98 /MaxReadThrough="4.92442" /MaxDrop="6.75565" /score="45.1562234" /energy="-15.7" /TU="U3038" /idTUdmin="U3038" /TUdmin="-152" /isTUend="FALSE" CDS complement(3780348..3780680) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIA component" /protein_id="NP_391736.1" /db_xref="EnsemblGenomes-Gn:BSU38570" /db_xref="EnsemblGenomes-Tr:CAB15883" /db_xref="GOA:P46319" /db_xref="InterPro:IPR003188" /db_xref="InterPro:IPR036542" /db_xref="SubtiList:BG11349" /db_xref="UniProtKB/Swiss-Prot:P46319" /translation="MNEEMEQIIFQIILHGGNGRSSAMEAIAAAKSGDAEEARKKLQD AAEELSKAHHYQTELIQNEAGGEKTEMTLLMVHAQDHLMNAMTVKDMAAEIIELYEKI TEQRGASI*" gene complement(3780348..3780680) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" CDS complement(3780699..3782057) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIC component" /protein_id="NP_391737.1" /db_xref="EnsemblGenomes-Gn:BSU38580" /db_xref="EnsemblGenomes-Tr:CAB15884" /db_xref="GOA:P46317" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG11348" /db_xref="UniProtKB/Swiss-Prot:P46317" /translation="MNKVNQILEEKVMPIAGRIAGQRHLQALRDGIILTMPLIIIGSF FLIIGNLPIPGYAEFMAKTFGSSWSEKLAYPVDATFEIMGLVAAFGIAYRLAEKYGVD ALSAGAISLAAFLLATPYQVPFMPDGATKEIMVGGGIPLSLMGSKGLFVAMIIAMVST EIYRLIIQRNLVFKMPDGVPPAVSKSFVALIPGFAVIFLIWAARLIVEATPFESLHNI VSVLLGTPLSILGGSLGGSLVAEAVKMLLWACGLHGANIVGGVMAPIWYGAMDANRIA FQAGEELPKIFTQQFFDIWVNIGGSGATLALVVTMFLRARSKQMKQLGKLAVGPAIFN INEPIIFGMPIVMNPMLLLPFIITPLVTVTLTYIGMSTGLVAKPAGIAVPWTMPPIFS GYLATGGKVSGAVMQAINIAVSFVVYYPFFRMWDKQKLKEENDLELVQTPAATDDKEA AL*" gene complement(3780699..3782057) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" CDS complement(3782073..3782381) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 23874669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 23874669; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIB component" /protein_id="NP_391738.1" /db_xref="EnsemblGenomes-Gn:BSU38590" /db_xref="EnsemblGenomes-Tr:CAB15885" /db_xref="GOA:P46318" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR013012" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11347" /db_xref="UniProtKB/Swiss-Prot:P46318" /translation="MNILLVCAAGMSTSLLVSKMEKSAQEQGKDYTIWAVSGDSVQNH IDKADVLLLGPQVRYMLPQLKKLGESKGVPVDVINTVHYGTCNGAEVLKSAEQLGHVS *" gene complement(3782073..3782381) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" promotor_-10 complement(3782426..3782445) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3782442) /Source="Nicolas_upshifts" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" promotor_-35 complement(3782459..3782465) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3782510) /Source="Nicolas_upshifts" /id="D2001" /incds=0 /nref=3 /ntot=74 /MaxReadThrough="3.19679" /MaxDrop="2.70222" /score="27.6067633" /energy="-11.1" /TU="U3040" /idTUdmin="U3040" /TUdmin="-45" /isTUend="FALSE" CDS complement(3782510..3784435) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 9353933, 10438772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 9353933, 10438772; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the lichenan operon" /protein_id="NP_391739.1" /db_xref="EnsemblGenomes-Gn:BSU38600" /db_xref="EnsemblGenomes-Tr:CAB15886" /db_xref="GOA:P46321" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG11346" /db_xref="UniProtKB/Swiss-Prot:P46321" /translation="MLHGRLRDILRLLMAAEAPVTSSFFAAQLNVTTRTVRNDIKELQ GVLSGHGAFVQSVRGSGYKLRIDDEQVFRTLLQDEFQQKKGLPVLPEERMAYLMKRLL LADHYLKLDELAEELFISKSTLQTDLKEVKKRLLPYRIVMETRPNYGFKLRGDEVQMR YCMAEYIVDERETEIDVLNEKADILPKEEIEIIRSAILKKMKNDRIPLSNMGLNNLII HIAIACKRIRTENYVSLFPKDMDHILHQKEYQAAEAIVKELESKLSVTFPKDETAYIT MHLLGTKRMTQSQCGEDTFSIEEETDQLTLAMIKAVDRELKLGILHDKELKIGLALHM KPAISRNRYGMNLRNPMLAAIKEHYPLAFEAGIIAGIVIKEQTGIEIHENEIGYLALH FGAAIERKKTESPPKRCIIVCASGAGSAQLLREKLRSHFGKRLDILGTAEYYSLDQMS YESIDFVISTIPIKKELPVPVLKVNTILGGTDFTKIESILSDEKEKANRYLKKELVFF QEDLRSKEEVIQFLGQKVVECGFADEEIIDSIFEREDMSPTCFGNLVAIPHPLVPQTK TTFWAVCTLKKPIDWESQRVQFVCLLCVEKENKADLQSMYKLLGSILDDPAAMNQLIK CRSYQELSDVFDQKMLS*" gene complement(3782510..3784435) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" promotor_-35 3783173..3783182 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3783196..3783215 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3783204 /Source="Nicolas_upshifts" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3784508..3784525) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-10" upshifts complement(3784532) /Source="Nicolas_upshifts" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" promotor_-35 complement(3784540..3784547) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-35" CDS complement(3784598..3784756) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391740.1" /db_xref="EnsemblGenomes-Gn:BSU38610" /db_xref="EnsemblGenomes-Tr:CAB15887" /db_xref="SubtiList:BG14169" /db_xref="UniProtKB/Swiss-Prot:O32283" /translation="MVEKKEGRIGALKKMIKTVIKWAPVIYPIVRKIMKDRKASKQKN MSASRTAG*" gene complement(3784598..3784756) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" downshifts complement(3784625) /Source="Nicolas_upshifts" /id="D2002" /incds=0 /nref=75 /ntot=208 /MaxReadThrough="0.739420000000001" /MaxDrop="6.4099" /score="27.6067633" /energy="-11.1" /TU="NA" /idTUdmin="U3041" /TUdmin="-3" /isTUend="TRUE" CDS complement(3784785..3785375) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" /EC_number="3.2.2.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14729667, 27698084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14729667, 27698084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-alkylated purines and hypoxanthine DNA glycosidase" /protein_id="NP_391741.1" /db_xref="EnsemblGenomes-Gn:BSU38620" /db_xref="EnsemblGenomes-Tr:CAB15888" /db_xref="GOA:P94378" /db_xref="InterPro:IPR003180" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036995" /db_xref="SubtiList:BG12555" /db_xref="UniProtKB/Swiss-Prot:P94378" /translation="MTREKNPLPITFYQKTALELAPSLLGCLLVKETDEGTASGYIVE TEAYMGAGDRAAHSFNNRRTKRTEIMFAEAGRVYTYVMHTHTLLNVVAAEEDVPQAVL IRAIEPHEGQLLMEERRPGRSPREWTNGPGKLTKALGVTMNDYGRWITEQPLYIESGY TPEAISTGPRIGIDNSGEARDYPWRFWVTGNRYVSR*" gene complement(3784785..3785375) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" promotor_-10 complement(3785403..3785421) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3785414) /Source="Nicolas_upshifts" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" promotor_-35 complement(3785435..3785441) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3785444..3785450 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3785466..3785484 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3785469 /Source="Nicolas_upshifts" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" CDS 3785504..3787147 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9393707, 9555886, 10503549, 24123749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9555886, 10503549, 24123749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="major catalase in spores" /protein_id="NP_391742.1" /db_xref="EnsemblGenomes-Gn:BSU38630" /db_xref="EnsemblGenomes-Tr:CAB15889" /db_xref="GOA:P94377" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11945" /db_xref="UniProtKB/Swiss-Prot:P94377" /translation="MKDDHQNKQHQSNAQGSEEAFSHKTSGKNESEDTLTNRQGHPVT DNQNVRTVGNRGPTTLENYDFLEKISHFDRERIPERVVHARGAGAHGYFEAYGSFGDE PISTYTRAKLFQEKGKKTPAFVRFSTVNHGKHSPETLRDPRGFAVKLYTEDGNWDLVG NNLKIFFIRDPLKFPDLVHAFQPDPVTNIQDGERIFDFISQSPEATHMITFLFSPWGI PANYRQMQGSGVHAYKWVNEEGKAVLVKYHFEPKQGIRNLTQKEAEEIQGKNFNHATQ DLYDAIENGDYPEWEVYAQIMSDDEHPELDFDPLDPTKLWYKDDFPWKPIGKLVLNKN PENYHAEVEQASFGTGVLVDGLDFSDDKLLQGRTFAYSDTQRYRVGANYLQLPINSPK KHVATNQEGGQMQYRVDRAEGQNPHVNYEPSIMGGLKEAKQDGKDHTPHVEGDVKREA IDRTNNFGQAGETYRRFTEFERNELITNLVNTLSTCRKEIQDQMIENFTKADPDYGKR VAEGLKKVSENNSNGPIGTTETEQAAKQAEQESHPSDPY*" gene 3785504..3787147 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" S_feature complement(3785641..3787190) /Source="Nicolas_S_feature" /locus_tag="new_3965134_3966683_c" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T3.0H, S8, T3.30H, S6, T0.0H" /AntisenseName="katX" /AntisenseCor="0.28909015498211399" /AntisenseRegPval="-5.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1482" downshifts 3787142 /Source="Nicolas_upshifts" /id="D2003" /incds=0 /nref=28 /ntot=49 /MaxReadThrough="0.942820000000001" /MaxDrop="5.69337" /score="45.0252072" /energy="-12.7" /TU="NA" /idTUdmin="U3042" /TUdmin=0 /isTUend="TRUE" S_feature complement(3787192..3787283) /Source="Nicolas_S_feature" /locus_tag="new_3966685_3966776_c" /HighExp="T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, T3.30H, T4.0H, T3.0H, T0.0H, T5.0H" /AntisenseName="yxlH" /AntisenseCor="-4.8005444617814199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1483" promotor_-35 3787194..3787200 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3787208 /Source="Nicolas_upshifts" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 3787215..3787234 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3787235) /Source="Nicolas_upshifts" /id="D2004" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="3.81662" /MaxDrop="3.1285" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1557" /isTUend="FALSE" CDS 3787252..3788454 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391743.1" /db_xref="EnsemblGenomes-Gn:BSU38640" /db_xref="EnsemblGenomes-Tr:CAB15890" /db_xref="GOA:P94376" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12554" /db_xref="UniProtKB/Swiss-Prot:P94376" /translation="MELQQDLIPQKKTIGALDHAVFLCMVFCFWFSGYIYVPVFSLYL EDLHFSYGAIGIILGSYGVTQILLRFPLGLLSDILFSLRKQLLIAGFGFSVLSSLLFL MFDSFFFVLAARLFAGITASTWVMATILYAHYFNNGNASKAMGIMQFFTVMPQFASIV FCGLAAAHLGRQVPFWMALAASAAGLVICCFIQDPSAPPANRGTIRVNQYIKDTLRLP KLKLFTILSMTAHAVLFITVFGFTPLYMNQLGMGDAELLWVMSAFFLPHAAATLSFVF LRFTSRIAYSVMLISFAVTGVCLLYVPFLAALFTVCITHACIGLALGFVFPLLLSHVV EISSARLKMSVMGFYQSFYALGIFLGPLLAGKIAQLIGLAGVFYGAGSLAFAAFFVML AQKRNMIN*" gene 3787252..3788454 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" S_feature complement(3787285..3788450) /Source="Nicolas_S_feature" /locus_tag="new_3966778_3967943_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T0.0H, T3.0H, T3.30H, T-0.40H, T4.0H" /AntisenseName="yxlH" /AntisenseCor="-4.5703316381945601E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1484" downshifts complement(3787328) /Source="Nicolas_upshifts" /id="D2005" /incds=1 /nref=3 /ntot=61 /MaxReadThrough="6.44992" /MaxDrop="2.92619" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1650" /isTUend="FALSE" CDS complement(3788451..3789227) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC-transporter (permease)" /protein_id="NP_391744.2" /db_xref="EnsemblGenomes-Gn:BSU38650" /db_xref="EnsemblGenomes-Tr:CAB15891" /db_xref="GOA:P94375" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12553" /db_xref="UniProtKB/Swiss-Prot:P94375" /translation="MKVMMALLQKEWLEGWKSGKLIWLPIAMMIVGLTQPLTIYYMPE IIAHGGNLPDGMKISFTMPSGSEVMVSTLSQFNTLGMALVIFSVMGSVANERNQGVTA LIMSRPVTAAHYIVSKWLIQSVIGIMSFAAGYGLAYYYVRLLFEDASFSRFAASLGLY ALWVIFIVTAGLAGSTIFRSVGAAAACGIGLTAAVSFAVSLFPDGAKWLPAEICKQAE HILLHGERADFFGWSLTFSILCIMLLAVFSVWRFRRYESY*" gene complement(3788451..3789227) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" CDS complement(3789224..3790111) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter component (ATP-binding protein)" /protein_id="NP_391745.1" /db_xref="EnsemblGenomes-Gn:BSU38660" /db_xref="EnsemblGenomes-Tr:CAB15892" /db_xref="GOA:P94374" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12552" /db_xref="UniProtKB/Swiss-Prot:P94374" /translation="MLSIESLCKSYRHHEAVKNVSFHVNENECVALLGPNGAGKTTTL QMLAGLLSPTSGTIKLLGEKKLDRRLIGYLPQYPAFYSWMTANEFLTFAGRLSGLSKR KCQEKIGEMLEFVGLHEAAHKRIGGYSGGMKQRLGLAQALLHKPKFLILDEPVSALDP TGRFEVLDMMRELKKHMAVLFSTHVLHDAEQVCDQVVIMKNGEISWKGELQELKQQQQ TNVFTLSVKEKLEGWLEEKPYVSAIVYKNPSQAVFELPDIHAGRSLLSDCIRKGLTVT RFEQKTESLEDVYLKVVHA*" gene complement(3789224..3790111) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" CDS complement(3790118..3790306) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma-Y activity" /protein_id="NP_391746.1" /db_xref="EnsemblGenomes-Gn:BSU38670" /db_xref="EnsemblGenomes-Tr:CAB15893" /db_xref="GOA:P94373" /db_xref="InterPro:IPR027379" /db_xref="SubtiList:BG12551" /db_xref="UniProtKB/Swiss-Prot:P94373" /translation="MNISWEMILPLIVLQLALAVFALISCIKEERTNGPKWMWAAIIV CINIIGPILFFTVGRKQR*" gene complement(3790118..3790306) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" CDS complement(3790303..3790509) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative sigma-Y antisigma factor component" /protein_id="NP_391747.1" /db_xref="EnsemblGenomes-Gn:BSU38680" /db_xref="EnsemblGenomes-Tr:CAB15894" /db_xref="GOA:P94372" /db_xref="SubtiList:BG12550" /db_xref="UniProtKB/Swiss-Prot:P94372" /translation="MTQTEIIITVAACLIVLAQGIFLFIDAKKRNHMAWVWGIVGLIQ APMPLICYYFFVIRPDRKKRGIKQ*" gene complement(3790303..3790509) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" CDS complement(3790506..3790826) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sigma-Y antisigma factor" /protein_id="NP_391748.1" /db_xref="EnsemblGenomes-Gn:BSU38690" /db_xref="EnsemblGenomes-Tr:CAB15895" /db_xref="GOA:P94371" /db_xref="InterPro:IPR035238" /db_xref="SubtiList:BG12549" /db_xref="UniProtKB/Swiss-Prot:P94371" /translation="MNKEKLSDHLKSEWKKIDQTANPSIPNQKELLHQLSQMKAEYRK KLLQEIILFVFCALMVVSAAILAFTQAPAVFIVLQVCVLAVLPILIAAEKKRHLGECE VKRG*" gene complement(3790506..3790826) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" promotor_-35 3790639..3790648 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3790661..3790680 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3790663 /Source="Nicolas_upshifts" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3790819..3791355) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma-Y)" /protein_id="NP_391749.1" /db_xref="EnsemblGenomes-Gn:BSU38700" /db_xref="EnsemblGenomes-Tr:CAB15896" /db_xref="GOA:P94370" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11975" /db_xref="UniProtKB/Swiss-Prot:P94370" /translation="MDTQEEQRLIQQAKEGNDEAFTALFHYHYSFLYKYLLKLSLHPD LSEELVQETFLKGYIHLRSFQGRSKFSTWLISIASRLYLDHQKKRKREWKRNQTVTEE TIRKIKWDVSAKGAEWSETLDLFSKLDPKLRTPVLLRHYYGYTYAEIGVMLQIKEGTV KSRVHKGLQQIRKEWDDE*" gene complement(3790819..3791355) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" upshifts complement(3791383) /Source="Nicolas_upshifts" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" promotor_-10 complement(3791384..3791399) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3791411..3791420) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3791486..3791493 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3791507..3791526 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3791516 /Source="Nicolas_upshifts" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" CDS 3791567..3792940 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2191181, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine-cytosine (pyridoxine) permease" /protein_id="NP_391750.1" /db_xref="EnsemblGenomes-Gn:BSU38710" /db_xref="EnsemblGenomes-Tr:CAB15897" /db_xref="GOA:P94369" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR026030" /db_xref="SubtiList:BG12548" /db_xref="UniProtKB/Swiss-Prot:P94369" /translation="MKVERRTIEYIPNEERHGKAKDLFPVWFGANMHITTLVTGTIPV AMGLNLFWSVAAIICGTLIGAIFMASHSAQGPQLGIPQMIQSRAQFGVIGAILPLFLV MFIYLGFFASSTILAAGTLSSFVPIPGSWSIIGLSAVCFLLTIFGHDLIHKMQKILSW TSFAVFFAATILIFQLPIPAGSWIPGAIDLPIFLVAVSAVATWQLAYAPYVADYSRYL PVKTPASKTFWYSYAGTSVSSIWMMLLGALLTTSLPDFTANSGSQIVQLFGPFSFIML IIVLFGQMAINVFNLYGAFMSTTTTLEPFLKLKVTPKVRIIMILGVTLVGTVLSLLGQ SNFMELFLNFIFFISYFLIPWTAINLVDYYFVRHGKYQVKAMFDVNGPYGKVNWITTI AFVLSILLEIPFINTSFYIGPLAKMFGGGDIAWIIGLAVPSVLYYVLMKPRLKKRAGY QEKLSSL*" gene 3791567..3792940 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" S_feature complement(3791847..3792389) /Source="Nicolas_S_feature" /locus_tag="new_3971340_3971882_c" /HighExp="Etha, LBGstat, T1.0H, T0.30H, Diami, T1.30H, dia15, G150, G135, G180" /AntisenseName="yxlA" /AntisenseCor="-8.6586358833710395E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1485" promotor_-10 complement(3792377..3792396) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3792389) /Source="Nicolas_upshifts" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3792411..3792418) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3792775 /Source="Nicolas_upshifts" /id="D2006" /incds=1 /nref=30 /ntot=136 /MaxReadThrough="1.87017" /MaxDrop="3.59478" /score="22.3054019" /energy="-12.9" /TU="NA" /idTUdmin="U3046" /TUdmin=0 /isTUend="TRUE" CDS complement(3792955..3793785) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12457846, 21994945, 22940582, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12457846, 21994945, 22940582, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H dehydratase" /protein_id="NP_391751.1" /db_xref="EnsemblGenomes-Gn:BSU38720" /db_xref="EnsemblGenomes-Tr:CAB15898" /db_xref="GOA:P94368" /db_xref="InterPro:IPR000631" /db_xref="InterPro:IPR017953" /db_xref="InterPro:IPR029056" /db_xref="PDB:1KYH" /db_xref="PDB:3RPH" /db_xref="PDB:3RPZ" /db_xref="PDB:3RQ2" /db_xref="PDB:3RQ5" /db_xref="PDB:3RQ6" /db_xref="PDB:3RQ8" /db_xref="PDB:3RQH" /db_xref="PDB:3RQQ" /db_xref="PDB:3RQX" /db_xref="SubtiList:BG12547" /db_xref="UniProtKB/Swiss-Prot:P94368" /translation="MNVPFWTEEHVRATLPERDAESHKGTYGTALLLAGSDDMPGAAL LAGLGAMRSGLGKLVIGTSENVIPLIVPVLPEATYWRDGWKKAADAQLEETYRAIAIG PGLPQTESVQQAVDHVLTADCPVILDAGALAKRTYPKREGPVILTPHPGEFFRMTGVP VNELQKKRAEYAKEWAAQLQTVIVLKGNQTVIAFPDGDCWLNPTGNGALAKGGTGDTL TGMILGMLCCHEDPKHAVLNAVYLHGACAELWTDEHSAHTLLAHELSDILPRVWKRFE *" gene complement(3792955..3793785) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" downshifts complement(3792961) /Source="Nicolas_upshifts" /id="D2007" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="3.50755" /MaxDrop="3.84264" /score="7.61210868" /energy="-12.9" /TU="U3048" /idTUdmin="U3051" /TUdmin=792 /isTUend="FALSE" promotor_-10 complement(3793804..3793822) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3793819) /Source="Nicolas_upshifts" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" promotor_-35 complement(3793837..3793843) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3793863) /Source="Nicolas_upshifts" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(3793865..3793884) /Source="Nicolas_upshift_promotors" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3793871..3795598) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391752.1" /db_xref="EnsemblGenomes-Gn:BSU38730" /db_xref="EnsemblGenomes-Tr:CAB15899" /db_xref="GOA:P94367" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014223" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11928" /db_xref="UniProtKB/Swiss-Prot:P94367" /translation="MKKEEWILPYIKQNARLFVLVIFLGAVTIFSAAFLMFTSGFLIS KAATRPENILLIYVPIVAVRTFGIARSVSRYVERLVGHHIILKIVSDMRVRLYNMLEP GALMLRSRFRTGDMLGILSEDIEHLQDAFLKTIFPAISALLLYAVSVIALGFFSWPFA ILLALYLFVLVVLFPVVSLLVTRAKNAKLKSGRNVLYSRLTDAVMGVSDWMFSGRRHA FIDAYEKEERDWFELERKKQRFTRWRDFAAQCLVAGLILLMLFWTAGQQADGELAKTM IAAFVLVVFPLTEAFLPLSDALGEVPGYQDSIRRMNNVAPQPEASQTESGDQILDLQD VTLAFRDVTFSYDNSSQVLHNFSFTLRQGEKMALLGRSGSGKSTSLALIEGALKPDSG SVTLNGVETALLKDQIADAVAVLNQKPHLFDTSILNNIRLGNGEASDEDVRRAAKQVK LHDYIESLPDGYHTSVQETGIRFSGGERQRIALARILLQDTPIIILDEPTVGLDPITE RELMETVFEVLKGKTILWITHHLAGVEAADKIVFLENGKTEMEGTHEELLAANERYRR LYHLDVPVK*" gene complement(3793871..3795598) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" downshifts complement(3793970) /Source="Nicolas_upshifts" /id="D2008" /incds=1 /nref=7 /ntot=46 /MaxReadThrough="5.39758" /MaxDrop="3.66431" /score="25.0271963" /energy="-10.6" /TU="U3051" /idTUdmin="U3051" /TUdmin="-217" /isTUend="FALSE" CDS complement(3795595..3797298) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391753.1" /db_xref="EnsemblGenomes-Gn:BSU38740" /db_xref="EnsemblGenomes-Tr:CAB15900" /db_xref="GOA:P94366" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014216" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11927" /db_xref="UniProtKB/Swiss-Prot:P94366" /translation="MGKDLFRYKGMKRILTLITCLTLIQTAAIIMQAEWLSEAVTGLF NGKGITSLLPVIGFFLIAFIARHGMTVARQKIVYQYAARTGADLRKSFLDQLFRLGPR FAKKEGTGQMVTLAMEGISQFRRYLELFLPKMVSMAIVPAAVVIYVFFQDRTSAIILV AAMPILIIFMILLGLVAQRKADRQWKSYQRLSNHFVDSLRGLETLRFLGLSKSHSKNI FYVSERYRKATMSTLRVAFLSSFALDFFTMLSVATVAVFLGLRLIDGDILLGPALTAL ILAPEYFLPVREVGNDYHATLNGQEAGKTIQEILSQPGFKEETPLQLEAWSDQDELKL SGVSVGRSVSDIHLSFKGKKKIGIIGASGAGKSTLIDILGGFLEPDGGMIEVNGTSRS HLQDGSWQKNLLYIPQHPYIFDDTLGNNIRFYHPSASAEDTTRAAASAGLTELVNNLP DGLEGRIGEGGRALSGGQAQRVALARAFLGNRPILLLDEPTAHLDIETEYEIKETMLD LFEDKLVFLATHRLHWMLDMDEIIVLDGGRVAEIGTHNELLEKNGVYTKLVKAQLGER A*" gene complement(3795595..3797298) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" CDS complement(3797298..3798314) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit II)" /protein_id="NP_391754.1" /db_xref="EnsemblGenomes-Gn:BSU38750" /db_xref="EnsemblGenomes-Tr:CAB15901" /db_xref="GOA:P94365" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG11926" /db_xref="UniProtKB/Swiss-Prot:P94365" /translation="MASLHDLWFILVAVLFVGFFFLEGFDFGVGMATRFLGHNELERR VLINTIGPFWDANEVWLLTGAGAIFAAFPNWYATMLSGYYIPFVIVLLALMGRGVAFE FRGKVDHLKWVKVWDWVVFFGSLIPPFVLGVLFTTLFRGMPIDADMNIHAHVSDYINV YSILGGVTVTLLCFQHGLMFITLRTIGDLQNRARKMAQKIMGVVFVAVLAFAALSAYQ TDMFTRRGEITIPLAVLIVICFMLAAVFIRKKKDGWTFGMTGAGLALTVGMIFISLFP RVMVSSLHSAYDLTVANASSGDYSLKVMSIAALTLLPFVIGSQIWSYYVFRKRVSHKE PMTY*" gene complement(3797298..3798314) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" promotor_-10 complement(3798188..3798206) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3798197) /Source="Nicolas_upshifts" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" promotor_-35 complement(3798222..3798227) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3798298..3799704) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit I)" /protein_id="NP_391755.1" /db_xref="EnsemblGenomes-Gn:BSU38760" /db_xref="EnsemblGenomes-Tr:CAB15902" /db_xref="GOA:P94364" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG11925" /db_xref="UniProtKB/Swiss-Prot:P94364" /translation="MSELVLARIQFASTTLFHFLFVPMSIGLVFMVALMETLYLVKKN ELYLKMAKFWGHLFLINFAVGVVTGILQEFQFGLNWSDYSRFVGDVFGAPLAIEALLA FFMESIFIGLWIFGWDRLPKKIHALCIWLVSFGTIMSSFWILTANSFMQEPVGFTIKN GRAEMNDFGALITNPQLWVEFPHVIFGALATGAFFIAGVSAFKLLKKKEVPFFKQSFK LAMIVGLCAGLGVGLSGHMQAEHLMESQPMKMAASEGLWEDSGDPAAWTAFATIDTKN EKSSNEIKVPYALSYLAYQKFSGSVKGMKTLQAEYEKIYGKGDYIPPVKTTFWSFRIM VGAGVVMILAALGGLWLNRRKKLENSKWYLRIMIALISFPFLANSAGWIMTEIGRQPW TVMGLMTTAQSVSPNVTAGSLLFSIIAFGVMYMILGALLVFLFIREIKKGAEHDNHHD VPVSTDPFSQEVYHGISS*" gene complement(3798298..3799704) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" S_feature complement(3799705..3799913) /Source="Nicolas_S_feature" /locus_tag="new_3979198_3979406_c" /HighExp="M0t45, ferm, UNK1, Gly, Lbexp, Lbstat, dia0, nit, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1486" promotor_-10 complement(3799896..3799915) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3799913) /Source="Nicolas_upshifts" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" S_feature complement(3799915..3800023) /Source="Nicolas_S_feature" /locus_tag="new_3979408_3979516_c" /HighExp="LPhT, LBGtran, ferm, LBGstat, M0t45, dia0, Etha, dia5, Lbexp, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1487" promotor_-35 complement(3799929..3799934) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3800020..3800039) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-10" upshifts complement(3800035) /Source="Nicolas_upshifts" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" promotor_-35 complement(3800053..3800060) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-35" promotor_-35 3800181..3800188 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3800198 /Source="Nicolas_upshifts" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" promotor_-10 3800203..3800221 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3800260..3801612 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11566984, 12525174, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11566984, 12525174, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="citrate/malate/H+ symporter" /protein_id="NP_391756.1" /db_xref="EnsemblGenomes-Gn:BSU38770" /db_xref="EnsemblGenomes-Tr:CAB15903" /db_xref="GOA:P94363" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12546" /db_xref="UniProtKB/Swiss-Prot:P94363" /translation="MGELQTHMQLQTDTIHEGVRKENWFAKAMNIKVGIIPLPVYALL FILITVFVMHHDVKSDILTSIAVMAFFGFTFAQIGKSIPIVRSIGGPAILATFIPSAV VYYHLLPNDIVKSTTEFTENSNFLYLFIAGIVVGSILGMKRETLVKAFMKIFIPLIVG SVTAAIVGLAVGTLLGLGFQHTLLYIVIPIMAGGVGEGAIPLSIGYSDIMPISQGEAF ALVLPSIMLGSLCAIILAGLLNRIGKKKPEWTGNGKVDRSEEESPALEESQSGQQMFN LSLFASGGILAVSLYLVGMLAHDFFGFPAPVAMLLLAVLIKLFRLVPASIENGAFGVS RFFSTAVTYPLLFAIGVSMTPWDKLVAAFNLSNIITILSVVVTMMAVGFFTGKWLNMY PIETAIINACHSGQGGTGDVAILSAAERLELMPFAQVSTRIGGAITVSLTLLLLHQFY *" gene 3800260..3801612 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" S_feature complement(3801211..3803693) /Source="Nicolas_S_feature" /locus_tag="new_3980704_3983186_c" /HighExp="Cold, C30, LBGstat, Paraq, GM 120, GM 90, H2O2, Oxctl, GM 25, GM 45" /AntisenseName="yxkI" /AntisenseCor="0.564471040461903" /AntisenseRegPval="-23.3" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1488" downshifts 3801597 /Source="Nicolas_upshifts" /id="D2009" /incds=0 /nref=63 /ntot=147 /MaxReadThrough="2.93791" /MaxDrop="3.97692" /score="3.68725156" /energy="-12.7" /TU="U3053" /idTUdmin="U3053" /TUdmin="-220" /isTUend="FALSE" misc_feature 3801688..3801707 /Source="Nicolas_upshift_promotors" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3801694 /Source="Nicolas_upshifts" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" CDS 3801734..3803422 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" /EC_number="3.4.24.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_391757.1" /db_xref="EnsemblGenomes-Gn:BSU38780" /db_xref="EnsemblGenomes-Tr:CAB15904" /db_xref="GOA:P94362" /db_xref="InterPro:IPR001915" /db_xref="SubtiList:BG12545" /db_xref="UniProtKB/Swiss-Prot:P94362" /translation="MPMGTHLFLFMLLGLGFYLISALAAKLIPAIDFWIDIVLWVGAA AYIFSHLSFMDGIVSLATMFYCYWTAMDLIVSERVEKPSGDWQEIELAKNKTRLLSDI TLTAIVFAGAVIFFIYGPDTSPLKYVILLGMISGGGALVKRILNVFSVKVFYSAALEK LHISSHYETRTYPLSDLKNIQLESTADLLKLHPLLTMYSSRLDLTTSFQQVIKLSLPG ETLFLTVKEPQKWKTILQEYTDAENNVDNVISVLPFYHRKNVKRLLGKLYFAASVKGV SAYALLVLALYALHASPWVMAVAVILYWVFNMYMSDRVLRAAMDAKSCHHPHVQAAAD KIFRSAGISHVRIYETESDDYNGMAVGMNVGRSMVILTSATLTLPQRVIEGILAHEAI HIKKRDVLSSQLLRFLYLGAVVGIFLLFEQHITHPEAHKIALWAFIMAIIILFQLYQS FCSQWMEVRADNLGASLLDGGYKQMAEALRILAVRQDEDIQKQSAYSSEAGEDELQID SLTRDKSWFFRLIDFQFAPHPPMYWRVGTLLSNKGHGVLKRWLRDRLKESITLK*" gene 3801734..3803422 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" promotor_-35 3803420..3803429 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3803441..3803456 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3803445 /Source="Nicolas_upshifts" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" CDS 3803480..3803680 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391758.1" /db_xref="EnsemblGenomes-Gn:BSU38790" /db_xref="EnsemblGenomes-Tr:CAB15905" /db_xref="SubtiList:BG14168" /db_xref="UniProtKB/Swiss-Prot:O32284" /translation="MIVIILLFISIIVFLSVIQPQPSKNKSRQQADSGYFGYSDHSSH HDGCSSDGGFSDSGCGGGGGGD*" gene 3803480..3803680 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" S_feature 3803681..3804625 /Source="Nicolas_S_feature" /locus_tag="new_3983174_3984118" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T0.0H, T-0.40H, Salt, T3.30H, T3.0H" /AntisenseName="yxkH" /AntisenseCor="0.147753218660366" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1489" CDS complement(3803694..3804533) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported polysaccharide deacetylase, lipoprotein" /protein_id="NP_391759.1" /db_xref="EnsemblGenomes-Gn:BSU38800" /db_xref="EnsemblGenomes-Tr:CAB15906" /db_xref="GOA:P94361" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG12544" /db_xref="UniProtKB/Swiss-Prot:P94361" /translation="MKRLFLSIFLLGSCLALAACADQEANAEQPMPKAEQKKPEKKAV QVQKKEDDTSAWIKTEKPAKLPILMYHSISSGNSLRVPKKEFEAHMKWLHDNGYQTLT PKEASLMLTQDKKPSEKCVLITFDDGYTDNYQDAYPVLKKYGMKATIFMIGKSIGHKH HLTEEQMKEMAQHGISIESHTIDHLELNGLTPQQQQSEMADSKKLFDNMFHQQTTIIS YPVGRYNEETLKAAEKTGYQMGVTTEPGAASRDQGMYALHRVRVSPGMSGSAFGAYIE SMK*" gene complement(3803694..3804533) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" promotor_-10 complement(3804559..3804577) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3804577) /Source="Nicolas_upshifts" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" promotor_-35 complement(3804590..3804597) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3804592 /Source="Nicolas_upshifts" /id="D2010" /incds=0 /nref=27 /ntot=142 /MaxReadThrough="0.40982" /MaxDrop="6.50242" /score="33.6694147" /energy="-13.4" /TU="NA" /idTUdmin="U3055" /TUdmin=3 /isTUend="TRUE" CDS complement(3804640..3805737) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multiple sugar (maltodextrins) transporter ATP-binding protein" /protein_id="NP_391760.1" /db_xref="EnsemblGenomes-Gn:BSU38810" /db_xref="EnsemblGenomes-Tr:CAB15907" /db_xref="GOA:P94360" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005116" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11954" /db_xref="UniProtKB/Swiss-Prot:P94360" /translation="MAELRMEHIYKFYDQKEPAVDDFNLHIADKEFIVFVGPSGCGKS TTLRMVAGLEEISKGDFYIEGKRVNDVAPKDRDIAMVFQNYALYPHMTVYDNIAFGLK LRKMPKPEIKKRVEEAAKILGLEEYLHRKPKALSGGQRQRVALGRAIVRDAKVFLMDE PLSNLDAKLRVQMRAEIIKLHQRLQTTTIYVTHDQTEALTMATRIVVMKDGKIQQIGT PKDVYEFPENVFVGGFIGSPAMNFFKGKLTDGLIKIGSAALTVPEGKMKVLREKGYIG KEVIFGIRPEDIHDELIVVESYKNSSIKAKINVAELLGSEIMIYSQIDNQDFIARIDA RLDIQSGDELTVAFDMNKGHFFDSETEVRIR*" gene complement(3804640..3805737) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" downshifts complement(3804641) /Source="Nicolas_upshifts" /id="D2011" /incds=0 /nref=81 /ntot=171 /MaxReadThrough="3.31232" /MaxDrop="7.04855" /score="29.2689404" /energy="-14.4" /TU="U3057" /idTUdmin="U3058" /TUdmin=2 /isTUend="TRUE" promotor_-10 complement(3805770..3805789) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3805787) /Source="Nicolas_upshifts" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" S_feature complement(3805789..3805857) /Source="Nicolas_S_feature" /locus_tag="new_3985282_3985350_c" /HighExp="M0t90, M40t90, Lbstat, Lbtran, T2.0H, dia5, T2.30H, M9-stat, S2, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1490" promotor_-35 complement(3805802..3805809) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3805858..3806751) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10746760" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10746760; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates yxkF-msmX expression)" /protein_id="NP_391761.1" /db_xref="EnsemblGenomes-Gn:BSU38820" /db_xref="EnsemblGenomes-Tr:CAB15908" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12543" /db_xref="UniProtKB/Swiss-Prot:P94359" /translation="MKSLLAIYPGSIVSEELCIREGCLCFFDESNQRYISIPKTEISE KEVLVLQSFLTPADEGNQLSMKSPEENKWFSFLFSRGELPAYIKKRTRFVHFHLFGKI ERTSFTEAVRHFWPVSFVIVWIHEDRGVIVEQESEAAAEKDELESLAKVLESDFYFSV RFYAGRFYEPDECLRKHYAREQAYFLFAEKRLPQVQSVTFEMIFPFLLLETEKEKLET LLSEEAELLFGSESELRKTIKLFIENNSNVTLTAKKLHLHRNSLQYRIDKFIERSGID IKSYKGALLAYFICLQNESSE*" gene complement(3805858..3806751) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" promotor_-10 complement(3806778..3806797) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3806797) /Source="Nicolas_upshifts" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" promotor_-35 complement(3806811..3806818) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3806825..3806830 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3806846..3806864 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3806855 /Source="Nicolas_upshifts" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 3806872..3806878 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3806893..3806911 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3806899 /Source="Nicolas_upshifts" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" CDS 3806935..3808392 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391762.1" /db_xref="EnsemblGenomes-Gn:BSU38830" /db_xref="EnsemblGenomes-Tr:CAB15909" /db_xref="GOA:P94358" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="PDB:4DNG" /db_xref="SubtiList:BG11903" /db_xref="UniProtKB/Swiss-Prot:P94358" /translation="MSFETLNKSFINGKWTGGESGRTEDILNPYDQSVITTASLATGK QLEDAFDIAQKAQKEWAKSTTEDRKAVLQKARGYLHENRDDIIMMIARETGGTIIKST IELEQTIAILDEAMTYTGELGGVKEVPSDIEGKTNKIYRLPLGVISSISPFNFPMNLS MRSIAPAIALGNSVVHKPDIQTAISGGTIIAKAFEHAGLPAGVLNVMLTDVKEIGDGM LTNPIPRLISFTGSTAVGRHIGEIAGRAFKRMALELGGNNPFAVLSDADVDRAVDAAI FGKFIHQGQICMIINRIIVHQDVYDEFVEKFTARVKQLPYGDQTDPKTVVGPLINERQ IEKALEIIEQAKTDGIELAVEGKRVGNVLTPYVFVGADNNSKIAQTELFAPIATIIKA GSDQEAIDMANDTEYGLSSAVFTSDLEKGEKFALQIDSGMTHVNDQSVNDSPNIAFGG NKASGVGRFGNPWVVEEFTVTKWISIQKQYRKYPF*" gene 3806935..3808392 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" promotor_-10 complement(3807818..3807836) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3807833) /Source="Nicolas_upshifts" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3807851..3807856) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3808373 /Source="Nicolas_upshifts" /id="D2012" /incds=0 /nref=14 /ntot=39 /MaxReadThrough="1.43471" /MaxDrop="4.03346" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=0 /isTUend="TRUE" downshifts 3808417 /Source="Nicolas_upshifts" /id="D2013" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="1.40793" /MaxDrop="3.07407" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=44 /isTUend="FALSE" CDS complement(3808434..3809270) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10735877, 10931887, 15096624, 15849754, 16850406, 21317561; Product type t : transporter" /codon_start=1 /transl_table=11 /product="guanidinium exporter" /protein_id="NP_391763.1" /db_xref="EnsemblGenomes-Gn:BSU38840" /db_xref="EnsemblGenomes-Tr:CAB15910" /db_xref="GOA:P94357" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12542" /db_xref="UniProtKB/Swiss-Prot:P94357" /translation="MKKRMLDVLMLVIGAFFFALAVNLFAIPNDLGEGGVTGITLILY YLFQWSPGVTNFILNAFLLLIGYKFLDGKTTVYTIIAVAANSLFLHLTHGWSIPSDEL IINTIFAGVFAGVGIGMIIRVGGTTAGSAILARIANKYLDWNISYALLFFDLIVVFSS YFIIGAEKMMFTIVMLYIGTKVMDFIIEGLNTKKAITVISENKSEIAEQVNTLMDRGV TILSGKGNYTGQSKEILYIVINKQELSMLKKIIRSCDKKAFVIVHDVRDVFGEGFVDI SK*" gene complement(3808434..3809270) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" downshifts complement(3808452) /Source="Nicolas_upshifts" /id="D2014" /incds=0 /nref=19 /ntot=137 /MaxReadThrough="1.00689" /MaxDrop="4.07213" /score="21.5028874" /energy="-13.8" /TU="NA" /idTUdmin="U3062" /TUdmin="-3" /isTUend="TRUE" misc_RNA complement(3809347..3809449) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" /product="guanidine riboswitch (type I)" /experiment="publication(s) with functional evidences, PMID:21317561, 27989440, 28096518" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21317561, 27989440, 28096518" gene complement(3809347..3809449) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" downshifts complement(3809373) /Source="Nicolas_upshifts" /id="D2015" /incds=0 /nref=194 /ntot=247 /MaxReadThrough="3.21415" /MaxDrop="5.58394" /score="-0.190335837" /energy="-10.7" /TU="U3062" /idTUdmin="U3065" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3809475..3809494) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3809486) /Source="Nicolas_upshifts" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" S_feature complement(3809488..3810229) /Source="Nicolas_S_feature" /locus_tag="new_3988981_3989722_c" /HighExp="S6, S8, S7, C30, S5, Gly, C90, Fru, BT, Pyr" /AntisenseName="yxkC" /AntisenseCor="-0.38162570069976298" /AntisenseRegPval="-10" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1491" promotor_-35 complement(3809508..3809514) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3809566..3809573 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3809586..3809604 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3809595 /Source="Nicolas_upshifts" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" S_feature 3809605..3809690 /Source="Nicolas_S_feature" /locus_tag="new_3989098_3989183" /HighExp="Cold, SMM, MG 150, GM 90, Glu, C30, GM 150, GM-0.2, GM 15, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1492" promotor_-35 3809666..3809673 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3809687..3809706 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3809692 /Source="Nicolas_upshifts" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" CDS 3809838..3810380 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818, 15033535" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391764.2" /db_xref="EnsemblGenomes-Gn:BSU38850" /db_xref="EnsemblGenomes-Tr:CAB15911" /db_xref="GOA:P94356" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="SubtiList:BG12541" /db_xref="UniProtKB/Swiss-Prot:P94356" /translation="MRHKIITFILAVVVIIIIGNMIGGGGGSEATSKTSSSSKAETEK TYNIGDTVKTEKTEVTVTKVEDRDTVGTQYVEKKASEGGTIVAVQYTIKNVSKKPISS FSIPTVKLVDADGTSYDSDIDASVNYATETKVDNSKILSDLNPNIKVTGVKAFEVDKE AYAKGTWKLKFSNDVIVKIK*" gene 3809838..3810380 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" promotor_-10 complement(3810205..3810224) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3810229) /Source="Nicolas_upshifts" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" promotor_-35 complement(3810238..3810247) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3810370 /Source="Nicolas_upshifts" /id="D2016" /incds=0 /nref=78 /ntot=276 /MaxReadThrough="4.33141" /MaxDrop="6.78221" /score="9.28209494" /energy="-14.4" /TU="U3063,U3064" /idTUdmin="U3064" /TUdmin="-181" /isTUend="FALSE" S_feature 3810415..3810737 /Source="Nicolas_S_feature" /locus_tag="new_3989908_3990230" /HighExp="Cold, C30, Heat, Fru, Glu, C90, BMM, Glucon, M/G, Mal" /AntisenseName="galE" /AntisenseCor="0.165797390333391" /AntisenseRegPval="-2.2000000000000002" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1493" CDS complement(3810455..3811474) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" /EC_number="5.1.3.7" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1906927, 9555917, 14597172" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906927, 9555917, 14597172; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 4-epimerase" /protein_id="NP_391765.1" /db_xref="EnsemblGenomes-Gn:BSU38860" /db_xref="EnsemblGenomes-Tr:CAB15912" /db_xref="GOA:P55180" /db_xref="InterPro:IPR005886" /db_xref="InterPro:IPR008089" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11837" /db_xref="UniProtKB/Swiss-Prot:P55180" /translation="MAILVTGGAGYIGSHTCVELLNSGYEIVVLDNLSNSSAEALNRV KEITGKDLTFYEADLLDREAVDSVFAENEIEAVIHFAGLKAVGESVAIPLKYYHNNLT GTFILCEAMEKYGVKKIVFSSSATVYGVPETSPITEDFPLGATNPYGQTKLMLEQILR DLHTADNEWSVALLRYFNPFGAHPSGRIGEDPNGIPNNLMPYVAQVAVGKLEQLSVFG NDYPTKDGTGVRDYIHVVDLAEGHVKALEKVLNSTGADAYNLGTGTGYSVLEMVKAFE KVSGKEVPYRFADRRPGDIATCFADPAKAKRELGWEAKRGLEEMCADSWRWQSSNVNG YKSAE*" gene complement(3810455..3811474) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" downshifts complement(3810473) /Source="Nicolas_upshifts" /id="D2017" /incds=0 /nref=235 /ntot=261 /MaxReadThrough="1.7919" /MaxDrop="7.32805" /score="24.6899971" /energy="-14.8" /TU="NA" /idTUdmin="U3066" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3811500..3811519) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3811514) /Source="Nicolas_upshifts" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" promotor_-35 complement(3811534..3811537) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3811589..3812095) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phospholipid binding protein" /protein_id="NP_391766.1" /db_xref="EnsemblGenomes-Gn:BSU38870" /db_xref="EnsemblGenomes-Tr:CAB15913" /db_xref="InterPro:IPR005247" /db_xref="InterPro:IPR008914" /db_xref="InterPro:IPR036610" /db_xref="SubtiList:BG11899" /db_xref="UniProtKB/Swiss-Prot:P55185" /translation="MNIYVEANPYLHDKYSKYADEKYKREGNPFVSFPIHFDDIPSGA KTLALTFIDHDAIPVCGFSWIHWTAANIPAYIGELPEHASEERQDLMIQGQNSFASPL AGSNDPKVIHQYCGPTPPDKDHAYTLTVYALDAELNLQPGFYLNELYQEMKEHILAET SIELLARV*" gene complement(3811589..3812095) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" promotor_-10 complement(3812101..3812120) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3812123) /Source="Nicolas_upshifts" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" promotor_-35 3812125..3812128 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3812134..3812140) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3812143..3812162 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3812146 /Source="Nicolas_upshifts" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" CDS 3812225..3813100 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391767.1" /db_xref="EnsemblGenomes-Gn:BSU38880" /db_xref="EnsemblGenomes-Tr:CAB15914" /db_xref="GOA:P55181" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11898" /db_xref="UniProtKB/Swiss-Prot:P55181" /translation="MDLKWLQTFIAAAESESFREAAEHLYLTQPAVSQHMRKLEDELD MRLFLHSGRRVVLTDEGRLFLPYAKEMIHVYQAGKQKVSQWKQGYSRSLTLAVHPYIA SYILPRFLPAYIQKHPHVELSTHVAGSDAIKQAVEHNEADIGLSRKDPNTNTLYYQHI CEGTLCLAAPFQESRPDAASVLTRYRLLTHDHPSYGDAFLDNIRSHYPYLQMMAVGQT DTAVHMMKAGMGASFLPTYIIKQEEAEKKLMAVSTPAHLELPASQTFMMWKRNSEDIQ HFHAMLHDFMQREQV*" gene 3812225..3813100 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" S_feature complement(3812475..3812563) /Source="Nicolas_S_feature" /locus_tag="new_3991968_3992056_c" /HighExp="GM 60, MG-0.1, MG 10, GM 5, S8, T0.30H, BC, S6, GM 15, GM 150" /AntisenseName="yxjO" /AntisenseCor="0.14032494397598999" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0669" /TUlongSig="NA" /TUlongPSig="NA" /label="S1494" downshifts complement(3812497) /Source="Nicolas_upshifts" /id="D2018" /incds=1 /nref=22 /ntot=45 /MaxReadThrough="0.10815" /MaxDrop="6.05884" /score="5.06408541" /energy="-5.6" /TU="NA" /idTUdmin="U3069" /TUdmin=0 /isTUend="TRUE" promotor_no_box complement(3812523..3812623) /Source="Nicolas_upshift_promotors" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3812563) /Source="Nicolas_upshifts" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" CDS 3813178..3813651 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391768.1" /db_xref="EnsemblGenomes-Gn:BSU38890" /db_xref="EnsemblGenomes-Tr:CAB15915" /db_xref="GOA:P55182" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR020223" /db_xref="SubtiList:BG11897" /db_xref="UniProtKB/Swiss-Prot:P55182" /translation="MAMSPYIFIVLILIILSMYRERTVKPGKLLIIPLLLLWGVSASF QPAYFHSVLHVAISGILLLIGLACGFGIGKMVNVRIHPETGKVTSRGSLGSVILILVI LSLRMAARTWLPESNEMFIAIIHSMFFVPLGTITARNIMLYKAYRRLTAGKVSIQ*" gene 3813178..3813651 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" CDS 3813669..3814889 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YxjL]" /protein_id="NP_391769.1" /db_xref="EnsemblGenomes-Gn:BSU38900" /db_xref="EnsemblGenomes-Tr:CAB15916" /db_xref="GOA:P55183" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11896" /db_xref="UniProtKB/Swiss-Prot:P55183" /translation="MNGQTPARHYYKKLVPSLILILNCIQFLSHPTKADPILLAFVFA VYLAFIWIIPYVASTAVSLSIFIGLWLLTDFFWAVSGQEQGAAYFLIVFLMIYAAFRL PSRLSLIFTACLIGGNILLLSSQGGSLNTIISNISIMLGLYVLFSSMRFRREARREAE RNHAELAKMHVQLEHAHKELQKAHAELQEASVLSLRYAVLEERTRIARDIHDSIGHEL TSVIVQLQSLPYILKSSKEDSEKVIQNVLSVARECLQEVRSVVHQMGRSESMVGLTAL RGLIHQVEERSGLHVSLDTAGLSEESWPPNVSETIYRILQEALTNIIRHADASHAAAV ISNDKSHLYVTITDDGQFTGSLTYGFGLTGMKERAEKAGGSLTFSAVQPSGLKIELSL PLMTTNKEQKDEQR*" gene 3813669..3814889 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" CDS 3814876..3815532 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YxjM]" /protein_id="NP_391770.1" /db_xref="EnsemblGenomes-Gn:BSU38910" /db_xref="EnsemblGenomes-Tr:CAB15917" /db_xref="GOA:P55184" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11895" /db_xref="UniProtKB/Swiss-Prot:P55184" /translation="MNKDKIRVALADDQPLVREGFRYVINAQTDMTVSGEAGDGHDII ALAKQTKPDVILMDVQMPRCSGIEAAKDIMSALPNTKIVILTTFDTEEYVFEGIRAGA VGYLLKDTLPEELIDAIRAAARGEAIFRTVTAAKIISETFRAKQQTHAEELAEPFTKR ELEVLQQMAYGLRNEDIAEKLFVSESTVKTHVHRILQKCNAQDRTQAVVFAIRNGIVQ *" gene 3814876..3815532 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" promotor_-35 3815530..3815535 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3815549..3815568 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3815552 /Source="Nicolas_upshifts" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" CDS 3815582..3816814 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" /EC_number="3.4.11.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8978088, 10987140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8978088, 10987140; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidase T (tripeptidase)" /protein_id="NP_391771.1" /db_xref="EnsemblGenomes-Gn:BSU38920" /db_xref="EnsemblGenomes-Tr:CAB15918" /db_xref="GOA:P55179" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010161" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11842" /db_xref="UniProtKB/Swiss-Prot:P55179" /translation="MKEEIIERFTTYVKVDTQSDESVDTCPSTPGQLTLGNMLVDELK SIGMQDAAIDENGYVMATLPSNTEKDVPTIGFLAHVDTATDFTGKNVNPQIIESYDGK DIVLNEQLQVTLSPDQFPELSGYKGHTLITTDGTTLLGADNKAGIAEIMTAMDYLIKH PEIKHGTIRVAFTPDEEIGRGPHKFDVKRFNASFAYTVDGGPLGELEYESFNAAAAKI TIKGNNVHPGTAKGKMINSAKIAMKLNSLLPADEAPEYTEGYEGFYHLLSIQGDVEET KLHYIIRDFDKENFQNRKETMKRAVEELQNEYGQDRILLDMNDQYYNMREKIEPVIEI VNIAKQAMENLGIEPKISPIRGGTDGSQLSYMGLPTPNIFTGGENFHGKFEYISVDNM VKAVNVIVEIAKQFEAQA*" gene 3815582..3816814 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" downshifts complement(3815599) /Source="Nicolas_upshifts" /id="D2019" /incds=0 /nref=4 /ntot=116 /MaxReadThrough="0.86167" /MaxDrop="3.19485" /score="-2.15704435" /energy="-9.1" /TU="NA" /idTUdmin="U3069" /TUdmin="-3102" /isTUend="FALSE" downshifts 3816799 /Source="Nicolas_upshifts" /id="D2020" /incds=0 /nref=203 /ntot=244 /MaxReadThrough="3.3949" /MaxDrop="6.35116" /score="27.2051031" /energy="-13.5" /TU="U3070" /idTUdmin="U3070" /TUdmin="-22" /isTUend="TRUE" promotor_-35 3816860..3816869 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3816882..3816897 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3816884..3817106 /Source="Nicolas_S_feature" /locus_tag="new_3996377_3996599" /HighExp="T-0.40H, T0.30H, T0.0H, T-1.40H, T1.0H, T-1.10H, T3.30H, T2.0H, T1.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.80396299999999998" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1495" upshifts 3816884 /Source="Nicolas_upshifts" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" downshifts 3817063 /Source="Nicolas_upshifts" /id="D2021" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="4.83682" /MaxDrop="4.66302" /score="-1.57383757" /energy="-6.2" /TU="U3071" /idTUdmin="U3070" /TUdmin=242 /isTUend="FALSE" promotor_-35 3817117..3817123 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-35" S_feature 3817136..3817236 /Source="Nicolas_S_feature" /locus_tag="new_3996629_3996729" /HighExp="Etha, Gly, Sw, Salt, B60, T0.30H, LoTm, M9-stat, T1.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1496" upshifts 3817136 /Source="Nicolas_upshifts" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" promotor_-10 3817138..3817156 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-10" promotor_-35 3817215..3817222 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3817236..3817254 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3817238..3817335 /Source="Nicolas_S_feature" /locus_tag="new_3996731_3996828" /HighExp="Etha, T0.30H, Gly, T1.0H, Sw, Salt, T1.30H, GM 15, B60, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1497" upshifts 3817238 /Source="Nicolas_upshifts" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" CDS 3817336..3817599 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391772.1" /db_xref="EnsemblGenomes-Gn:BSU38930" /db_xref="EnsemblGenomes-Tr:CAB15919" /db_xref="GOA:P94353" /db_xref="SubtiList:BG12540" /db_xref="UniProtKB/Swiss-Prot:P94353" /translation="MLFIDLEFFEYFLAFYPYNREYQNFFWEVCNMILFIIIALCGYL LFSFSKDNRRKPQKTSPLPAAAPHHNNLIDLDAIRQKRRMHLS*" gene 3817336..3817599 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" promotor_-35 3817363..3817366 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3817381..3817400 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" upshifts 3817393 /Source="Nicolas_upshifts" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" downshifts 3817547 /Source="Nicolas_upshifts" /id="D2022" /incds=0 /nref=4 /ntot=92 /MaxReadThrough="7.33654" /MaxDrop="3.1638" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-110" /isTUend="FALSE" downshifts 3817591 /Source="Nicolas_upshifts" /id="D2023" /incds=0 /nref=44 /ntot=188 /MaxReadThrough="5.58502" /MaxDrop="4.5161" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-66" /isTUend="FALSE" promotor_-35 3817666..3817675 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3817681 /Source="Nicolas_upshifts" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" promotor_-10 3817687..3817702 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3817728..3818216 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391773.1" /db_xref="EnsemblGenomes-Gn:BSU38940" /db_xref="EnsemblGenomes-Tr:CAB15920" /db_xref="InterPro:IPR007612" /db_xref="InterPro:IPR025659" /db_xref="SubtiList:BG12539" /db_xref="UniProtKB/Swiss-Prot:P94352" /translation="MIELFMKQKMFSFKDAFHIYDRDEQETFKVEGRFFSLGDSLQMT DSSGKTLVSIEQKLMSLLPRYEISIGGKTVCEVTKKVTFSKPKFVISGLNWEIDGDLW RDEFQLTDGENVRMSVSKKWLSWGDSYHLQIAYEEDVLICTAIAIVLDMVLYNDEDES IF*" gene 3817728..3818216 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" promotor_-35 3818221..3818228 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3818242..3818261 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3818252 /Source="Nicolas_upshifts" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" misc_RNA 3818282..3818388 /gene="mswI" /locus_tag="BSU_misc_RNA_61" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" gene 3818282..3818388 /gene="mswI" /locus_tag="BSU_misc_RNA_61" downshifts 3818383 /Source="Nicolas_upshifts" /id="D2024" /incds=0 /nref=22 /ntot=102 /MaxReadThrough="7.18775" /MaxDrop="3.7896" /score="9.64734237" /energy="-14.5" /TU="U3075,U3076" /idTUdmin="U3072" /TUdmin=0 /isTUend="TRUE" CDS 3818471..3819604 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyl-tetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391774.2" /db_xref="EnsemblGenomes-Gn:BSU38950" /db_xref="EnsemblGenomes-Tr:CAB15921" /db_xref="GOA:P42319" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11157" /db_xref="UniProtKB/Swiss-Prot:P42319" /translation="MAQQTNVAGQKTEKQRKAPFRADHVGSLLRSVPVKEARQKKAAG EMTAEQLRDIENQEITRIVEKQKEIGLDVVTDGEFRRSWWHYDFLEGLDGVEPFIPAE GIQFHNTKTKARSIKVTGKLDFTSHPALGDYQFLHEIAGNATPKLTIPSPNMLFFGEK ADKGIYDDQEEYFHDMAQAYKKAIKAFYDAGCRYLQLDDTSWSLFFEDKGREVVRALG GDPETLPAIFAKTINDAVADRPDDLTITMHICRGNFRSTWAASGGYDAVAETILDGLN LDGLFLEYDDDRSGNFDPLRFVKRKDLQIVLGLITSKYGELENPEDVKRRINEAARFV SLDQLCLSPQCGFASTEEGNLLTEEQQWAKLRHVIDIANDVWR*" gene 3818471..3819604 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" S_feature complement(3818744..3818987) /Source="Nicolas_S_feature" /locus_tag="new_3998237_3998480_c" /HighExp="dia15, Diami, H2O2, dia5, C90, Paraq, Sw, BC, LBGstat, Lbtran" /AntisenseName="yxjH" /AntisenseCor="-0.34694665046491102" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1498" promotor_-10 complement(3818982..3819001) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3818991) /Source="Nicolas_upshifts" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" promotor_-35 complement(3819016..3819023) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3819610..3819617 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3819632..3819651 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3819638 /Source="Nicolas_upshifts" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" misc_RNA 3819673..3819779 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" gene 3819673..3819779 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" downshifts 3819726 /Source="Nicolas_upshifts" /id="D2025" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="8.35488" /MaxDrop="3.50346" /score="29.0146782" /energy="-14.5" /TU="U3075,U3076,U3078" /idTUdmin="U3075" /TUdmin="-1254" /isTUend="FALSE" S_feature 3819780..3819856 /Source="Nicolas_S_feature" /locus_tag="new_3999273_3999349" /HighExp="MG 5, MG t5, T1.0H, MG 10, T1.30H, BMM, T0.30H, T-0.40H, T0.0H, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigD, SigB, SigWXY" /TUlongPSig="0.554, 1, 1, 1" /label="S1499" CDS 3819857..3820993 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254, 21749987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391775.3" /db_xref="EnsemblGenomes-Gn:BSU38960" /db_xref="EnsemblGenomes-Tr:CAB15922" /db_xref="GOA:P42318" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11156" /db_xref="UniProtKB/Swiss-Prot:P42318" /translation="MSQQTTPAEQKSLQRKKPPFRADQVGSLLRSEPVKKARLQKAAG EMTAEQLRQIENDEIIRIVEKQKETGLNVVTDGEFRRAWWHFDFLENLDGVEPFTPEQ GIQFHNVQTKARGIKVTGDIDFSTHPMLEDYSFLHSIAGDATPKMTIPSPNMLFFRGK LEKDEYKNDYQLFQHDVSKAYKKAIQAFYDRGCRYLQLDDTAWAVFLSEKGLKQIEAF GTTPDELRQLFAKSINDAIADRPDDLTVTMHICRGNFQSTWTAEGGYDAAAETIFDGL NLDGLFLEYDDSRSGGFEPLRYVKRSDLQLVLGLVTSKFGELENPDDVKRRIEEASRY VSLDQLCLSPQCGFASTEEGNKLTEEQQWAKLRHVVEIANDVWK*" gene 3819857..3820993 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" downshifts 3820980 /Source="Nicolas_upshifts" /id="D2026" /incds=0 /nref=81 /ntot=187 /MaxReadThrough="4.24668" /MaxDrop="5.8124" /score="11.1243305" /energy="-12.8" /TU="U3076,U3078" /idTUdmin="U3075" /TUdmin=0 /isTUend="TRUE" CDS complement(3821046..3821819) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacid dehydrogenase" /protein_id="NP_391776.2" /db_xref="EnsemblGenomes-Gn:BSU38970" /db_xref="EnsemblGenomes-Tr:CAB15923" /db_xref="GOA:P42317" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011294" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11155" /db_xref="UniProtKB/Swiss-Prot:P42317" /translation="MRKQVALVTGAAGGIGFEIAREFAREGASVIVSDLRPEACEKAA SKLAEEGFDAAAIPYDVTKEAQVADTVNVIQKQYGRLDILVNNAGIQHVAPIEEFPTD TFEQLIKVMLTAPFIAMKHVFPIMKKQQFGRIINIASVNGLVGFAGKSAYNSAKHGVI GLTKVGALEGAPHGITVNALCPGYVDTQLVRNQLSDLSKTRNVPYDSVLEQVIFPLVP QKRLLSVKEIADYAVFLASEKAKGVTGQAVVLDGGYTAQ*" gene complement(3821046..3821819) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" downshifts complement(3821056) /Source="Nicolas_upshifts" /id="D2027" /incds=0 /nref=23 /ntot=63 /MaxReadThrough="0.65" /MaxDrop="6.97604" /score="24.6585594" /energy="-12.8" /TU="NA" /idTUdmin="U3079" /TUdmin=0 /isTUend="TRUE" CDS complement(3821836..3822486) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit B)" /protein_id="NP_391777.1" /db_xref="EnsemblGenomes-Gn:BSU38980" /db_xref="EnsemblGenomes-Tr:CAB15924" /db_xref="GOA:P42316" /db_xref="InterPro:IPR004164" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11154" /db_xref="UniProtKB/Swiss-Prot:P42316" /translation="MKEARKRMVKRAVQEIKDGMNVNLGIGMPTLVANEIPDGVHVML QSENGLLGIGPYPLEGTEDADLINAGKETITEVTGASYFDSAESFAMIRGGHIDLAIL GGMEVSEQGDLANWMIPGKMVKGMGGAMDLVNGAKRIVVIMEHVNKHGESKVKKTCSL PLTGQKVVHRLITDLAVFDFVNGRMTLTELQDGVTIEEVYEKTEADFAVSQSVLNS*" gene complement(3821836..3822486) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" CDS complement(3822483..3823199) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit A)" /protein_id="NP_391778.1" /db_xref="EnsemblGenomes-Gn:BSU38990" /db_xref="EnsemblGenomes-Tr:CAB15925" /db_xref="GOA:P42315" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11153" /db_xref="UniProtKB/Swiss-Prot:P42315" /translation="MGKVLSSSKEAAKLIHDGDTLIAGGFGLCGIPEQLILSIRDQGV KDLTVVSNNCGVDDWGLGLLLANKQIKKMIASYVGENKIFERQFLSGELEVELVPQGT LAERIRAGGAGIPGFYTATGVGTSIAEGKEHKTFGGRTYVLERGITGDVAIVKAWKAD TMGNLIFRKTARNFNPIAAMAGKITIAEAEEIVEAGELDPDHIHTPGIYVQHVVLGAS QEKRIEKRTVQQASGKGEAK*" gene complement(3822483..3823199) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" CDS complement(3823223..3824641) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative acid metabolite permease" /protein_id="NP_391779.3" /db_xref="EnsemblGenomes-Gn:BSU39000" /db_xref="EnsemblGenomes-Tr:CAB15926" /db_xref="GOA:P42314" /db_xref="SubtiList:BG11152" /db_xref="UniProtKB/Swiss-Prot:P42314" /translation="MELIIILLALGLLMFTAYRGFSVILFAPICALFAVLLTDPSHVL PFFSSIFMEKMAGFIKLYFPVFLLGAIFGKVVEMAGLAASIAKTIVRLVGAKRAILAI VLMGAVLTYSGVSLFVVVFAVYPFAKNMFQEANIPKRLIPGTIALGAFTFTMDALPGT PQIQNVIPTSFFKTDIYAAPWLGLMGAVIVLAAGMLYLESRRKKAQASGEGYGGFDSQ NAPAPESIESAAEPDKSPIRHALAFVPLILVGAVNKYFTIYLPKWYPNGFDFSSIGLK EFGRLDISSAAAIWSVEIALVIGIITTILFDWRSVFAQLKEGLNEGIGGALLASMNTG AEYGFGGIIAALPGFHKLSSGISHTFTDPLVNGAVTTTALAGITGSASGGMGIALSAM SEQYLQAIQAYNIPPEVMHRVISMASGGMDTLPHNGAVITLLAVTGLTHRQSYRDIFA ITLIKTAAVFAVIAIYSLTGLV*" gene complement(3823223..3824641) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" promotor_-10 complement(3823809..3823827) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3823828) /Source="Nicolas_upshifts" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" promotor_-35 complement(3823843..3823848) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3824642..3824726) /Source="Nicolas_S_feature" /locus_tag="new_4004135_4004219_c" /HighExp="S5, S4, S6, S3, S7, M9-stat, B60, S8, T4.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1500" promotor_-10 complement(3824710..3824728) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3824726) /Source="Nicolas_upshifts" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" promotor_-35 complement(3824744..3824749) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3824795..3825643) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" /EC_number="2.1.1.188" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11967079, 14999102, 18406425, 23716046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m(1)G748 methyltransferase (class II)" /protein_id="NP_391780.1" /db_xref="EnsemblGenomes-Gn:BSU39010" /db_xref="EnsemblGenomes-Tr:CAB15927" /db_xref="GOA:P42313" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR016718" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11151" /db_xref="UniProtKB/Swiss-Prot:P42313" /translation="MKRTVDFSMFRCPLCDSSMDAASGKSLICTERGHTFDLSRHGYV NFLTKPVKTSYGAELFEARSRLIGECGFFDPLHDAIAELISHPKSGHEAFTILDSGCG EGSHLNALCGFDYAGKAAIGTGIDLSKDGILKASKAFKDLMWAVADVARAPFHDRQFD VVLSIFSPSNYAEFHRLLKNDGMLIKVVPRSDYLIELRQFLYTDSPRRTYSNTAAVER FTANAAHSRPVRLRYVKTLDQQAIHWLLKMTPLAWSAPKDRVSLLKEMKSADITVDVD ILIGMK*" gene complement(3824795..3825643) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" downshifts complement(3824805) /Source="Nicolas_upshifts" /id="D2028" /incds=0 /nref=54 /ntot=218 /MaxReadThrough="1.618" /MaxDrop="4.63737" /score="17.0758624" /energy="-15.1" /TU="NA" /idTUdmin="U3081" /TUdmin="-9" /isTUend="TRUE" S_feature complement(3825644..3825829) /Source="Nicolas_S_feature" /locus_tag="new_4005137_4005322_c" /HighExp="B60, LBGstat, LPhT, M9-stat, C30, T0.30H, HPh, Oxctl, Heat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1501" promotor_-10 complement(3825818..3825837) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3825829) /Source="Nicolas_upshifts" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" S_feature complement(3825831..3826556) /Source="Nicolas_S_feature" /locus_tag="new_4005324_4006049_c" /HighExp="LBGstat, C30, GM 25, Heat, GM 10, GM 45, GM 60, GM 90, T0.30H, GM 120" /AntisenseName="NA" /AntisenseCor="0.20859849915331599" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1502" promotor_-35 complement(3825853..3825857) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3825991..3825998 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3826011..3826030 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3826020 /Source="Nicolas_upshifts" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" misc_RNA 3826030..3826132 /gene="gswB" /locus_tag="BSU_misc_RNA_63" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" gene 3826030..3826132 /gene="gswB" /locus_tag="BSU_misc_RNA_63" S_feature 3826133..3826236 /Source="Nicolas_S_feature" /locus_tag="new_4005626_4005729" /HighExp="C90, G180, M40t45, dia15, LBGexp, Lbexp, Lbtran, G135, Mt0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1503" promotor_-35 3826208..3826214 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3826228..3826239 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3826238 /Source="Nicolas_upshifts" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" CDS 3826259..3827452 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12787499, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="purine nucleoside transporter" /protein_id="NP_391781.2" /db_xref="EnsemblGenomes-Gn:BSU39020" /db_xref="EnsemblGenomes-Tr:CAB15928" /db_xref="GOA:P42312" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG11150" /db_xref="UniProtKB/Swiss-Prot:P42312" /translation="MYFLLNLVGLIVIMAVVFLCSPQKKKIKWRPIITLIVLELLITW FMLGTKVGSWAIGKIGDFFTWLIACASDGIAFAFPSVMANETVDFFFSALLPIIFIVT FFDILTYFGILPWLIDKIGWVISKASRLPKLESFFSIQMMFLGNTEALAVIRQQLTVL SNNRLLTFGLMSMSSISGSIIGSYLSMVPATYVFTAIPLNCLNALIIANLLNPVHVPE DEDIIYTPPKEEKKDFFSTISNSMLVGMNMVIVILAMVIGYVALTSAVNGILGVFVHG LTIQTIFAYLFSPFAFLLGLPVHDAMYVAQLMGMKLATNEFVAMLDLKNNLKSLPPHT VAVATTFLTSFANFSTVGMIYGTYNSILDGEKSTVIGRNVWKLLVSGIAVSLLSAAIV GLFVW*" gene 3826259..3827452 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" promotor_-10 complement(3826543..3826561) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3826559) /Source="Nicolas_upshifts" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" promotor_-35 complement(3826574..3826581) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3827228 /Source="Nicolas_upshifts" /id="D2029" /incds=1 /nref=1 /ntot=58 /MaxReadThrough="5.88279" /MaxDrop="2.4159" /score="8.04757856" /energy="-16.6" /TU="U3082,U3083" /idTUdmin="U3082" /TUdmin="-220" /isTUend="FALSE" downshifts 3827448 /Source="Nicolas_upshifts" /id="D2030" /incds=0 /nref=71 /ntot=204 /MaxReadThrough="2.7474" /MaxDrop="4.05925" /score="8.04757856" /energy="-16.6" /TU="NA" /idTUdmin="U3082" /TUdmin=0 /isTUend="TRUE" CDS complement(3827494..3827922) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminus)" /translation="KTKKQANSRALKREYQTSFSVKYNAAGKLSIQTLNYIYSGGAHG LTSVQSFNYDLKAQKRVTLDQILNTKTKVSKTRDYLYSYIKKHDVLFFSDVKKEDITL NRDTMFYFTANGIAIVFGQYDLGPYAAGIRDVQVPASIYQ*" gene complement(3827494..3827922) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /pseudo CDS complement(3827923..3828165) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (N-terminus)" /db_xref="PSEUDO:CAB15929.2" /db_xref="SubtiList:BG11149" /db_xref="UniProtKB/Swiss-Prot:P42311" /translation="MKWNNMLKAAGIAVLLFSVFAYAAPSLKAVQAKTPTVSTHTYKK IKELTYPQVHHVGNAAFEKKINQELKAYMNNRIRNT*" gene complement(3827923..3828165) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /pseudo S_feature complement(3828166..3828229) /Source="Nicolas_S_feature" /locus_tag="new_4007659_4007722_c" /HighExp="T2.30H, S6, Etha, T3.30H, S5, BT, T3.0H, T4.0H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.942" /TUlongSig="NA" /TUlongPSig="NA" /label="S1504" promotor_-10 complement(3828218..3828233) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3828229) /Source="Nicolas_upshifts" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" promotor_-35 complement(3828245..3828254) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3828262 /Source="Nicolas_upshifts" /id="D2031" /incds=0 /nref=10 /ntot=69 /MaxReadThrough="0.814549999999999" /MaxDrop="3.89525" /score="14.5338714" /energy="-6.9" /TU="NA" /idTUdmin="U3082" /TUdmin=814 /isTUend="FALSE" CDS complement(3828310..3828600) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391783.2" /db_xref="EnsemblGenomes-Gn:BSU39040" /db_xref="EnsemblGenomes-Tr:CAB15930" /db_xref="SubtiList:BG11148" /db_xref="UniProtKB/Swiss-Prot:P42310" /translation="MNEKQLTEAYERDENMMILVFAQWCVNHDLDPMELYAKAYPQQK LNESLKKTMDDLVVPKHEAEHIPDQTVIAVLEMFGNTDLAQALHEAISGRKQ*" gene complement(3828310..3828600) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" downshifts complement(3828316) /Source="Nicolas_upshifts" /id="D2032" /incds=0 /nref=168 /ntot=241 /MaxReadThrough="3.10756" /MaxDrop="6.10709" /score="16.5130207" /energy="-6.9" /TU="NA" /idTUdmin="U3086" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3828625..3828644) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3828642) /Source="Nicolas_upshifts" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" CDS complement(3828650..3830710) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7559348, 8931328, 16151211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559348, 8931328, 16151211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catalase 2" /protein_id="NP_391784.2" /db_xref="EnsemblGenomes-Gn:BSU39050" /db_xref="EnsemblGenomes-Tr:CAB15931" /db_xref="GOA:P42234" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024712" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11102" /db_xref="UniProtKB/Swiss-Prot:P42234" /translation="MSDDQNKRVNEHSKDEQLEQYRTDNSGKKMTTNQGLRVSEDEHS LKAGVRGPTLMEDFHFREKMTHFDHERIPERVVHARGFGVHGFFQVYEPMTEYTRAKF LQDPSVKTPVFVRFSTVAGSKGSADTVRDARGFATKFYTEEGNYDLVGNNIPVFFIQD AIKFPDLVHAFKPEPHNEMPQAATAHDTFWDFVANNPESAHMVMWTMSDRGIPRSYRM MEGFGVHTFRFVNEQGKARFVKFHWKPVLGVHSLVWDEAQKIAGKDPDFHRRDLWETI ENGGKVEYELGVQMIDEEDEFKFDFDILDPTKLWPEELVPVKIIGKMTLNRNQDNVFA ETEQVAFHPGNVVPGIDFTNDPLLQGRLFSYTDTQLIRLGGPNFHEIPINRPVCPFHN NQYDGYHRMTINKGPVAYHKNSLQNNDPSPATAEEGGYVHYQEKVEGKKIRQRSDSFN DYYSQAKLFWNSMSPVEKQHIISAFCFEVGKVKSKDVQRQVVDVFSNVDADLAEEIAK GVGVAAPAKRKASKEILTSPALSQARTVKTASTRKVAVLAGNGFHEKELQTVLEALKQ EGITVDIISQNLGYMTSGSGQQLEASGTFLTVDSVLYDAVYAAGGLELKDNKQAMAFI REAYNHYKAIGAANEGIDLLQSSVGTTEGLGIVTAKDEPDYTAFSKAFIDAVAAHRHW DRRI*" gene complement(3828650..3830710) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" promotor_-35 complement(3828658..3828665) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3830739..3830757) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3830743) /Source="Nicolas_upshifts" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" promotor_-35 complement(3830772..3830778) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3830803..3830808 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3830822 /Source="Nicolas_upshifts" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" promotor_-10 3830824..3830842 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3830836..3830910 /Source="Nicolas_S_feature" /locus_tag="new_4010329_4010403" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, LoTm, BT, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1505" CDS 3830911..3832191 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8892821, 11053381, 15849754, 16850406, 18556792" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8892821, 11053381, 15849754, 16850406, 18556792; Product type t : transporter" /codon_start=1 /transl_table=11 /product="secondary transporter of divalent metal ions/citrate complexes" /protein_id="NP_391785.2" /db_xref="EnsemblGenomes-Gn:BSU39060" /db_xref="EnsemblGenomes-Tr:CAB15932" /db_xref="GOA:P42308" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11146" /db_xref="UniProtKB/Swiss-Prot:P42308" /translation="MLAILGFVMMIVFMYLIMSNRLSALIALIVVPIVFALISGFGKD LGEMMIQGVTDLAPTGIMLLFAILYFGIMIDSGLFDPLIAKILSFVKGDPLKIAVGTA VLTMTISLDGDGTTTYMITIAAMLPLYKRLGMNRLVLAGIAMLGSGVMNIIPWGGPTA RVLASLKLDTSEVFTPLIPAMIAGILWVIAVAYILGKKERKRLGVISIDHAPSSDPEA APLKRPALQWFNLLLTVALMAALITSLLPLPVLFMTAFAVALMVNYPNVKEQQKRISA HAGNALNVVSMVFAAGIFTGILSGTKMVDAMAHSLVSLIPDAMGPHLPLITAIVSMPF TFFMSNDAFYFGVLPIIAEAASAYGIDAAEIGRASLLGQPVHLLSPLVPSTYLLVGMA GVSFGDHQKFTIKWAVGTTIVMTIAALLIGIISF*" gene 3830911..3832191 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" S_feature 3832192..3832331 /Source="Nicolas_S_feature" /locus_tag="new_4011685_4011824" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, BT, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.382965" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1506" downshifts 3832288 /Source="Nicolas_upshifts" /id="D2033" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.69139" /MaxDrop="3.50434" /score="10.8797157" /energy="-9" /TU="NA" /idTUdmin="U3088" /TUdmin=0 /isTUend="TRUE" CDS complement(3832349..3833077) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" /EC_number="3.2.1.73" /EC_number="3.2.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1369198, 3106158, 7704256, 20600285, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1369198, 3106158, 7704256, 20600285, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,3-1,4 glucanase" /protein_id="NP_391786.1" /db_xref="EnsemblGenomes-Gn:BSU39070" /db_xref="EnsemblGenomes-Tr:CAB15943" /db_xref="GOA:P04957" /db_xref="InterPro:IPR000757" /db_xref="InterPro:IPR008263" /db_xref="InterPro:IPR008264" /db_xref="InterPro:IPR013320" /db_xref="PDB:3O5S" /db_xref="SubtiList:BG10476" /db_xref="UniProtKB/Swiss-Prot:P04957" /translation="MPYLKRVLLLLVTGLFMSLFAVTATASAQTGGSFFDPFNGYNSG FWQKADGYSNGNMFNCTWRANNVSMTSLGEMRLALTSPAYNKFDCGENRSVQTYGYGL YEVRMKPAKNTGIVSSFFTYTGPTDGTPWDEIDIEFLGKDTTKVQFNYYTNGAGNHEK IVDLGFDAANAYHTYAFDWQPNSIKWYVDGQLKHTATNQIPTTPGKIMMNLWNGTGVD EWLGSYNGVNPLYAHYDWVRYTKK*" gene complement(3832349..3833077) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" downshifts complement(3832366) /Source="Nicolas_upshifts" /id="D2034" /incds=0 /nref=64 /ntot=139 /MaxReadThrough="1.52649" /MaxDrop="6.38109" /score="-8.35070051" /energy="-16.3" /TU="NA" /idTUdmin="U3089" /TUdmin="-2" /isTUend="TRUE" promotor_-10 complement(3833108..3833127) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3833119) /Source="Nicolas_upshifts" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" promotor_-35 complement(3833141..3833148) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3833265..3833372) /Source="Nicolas_S_feature" /locus_tag="new_4012758_4012865_c" /HighExp="Sw, LPhT, T0.30H, M0t90, M9-stat, M40t90, Lbtran, Lbstat, S2, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1507" downshifts complement(3833308) /Source="Nicolas_upshifts" /id="D2035" /incds=0 /nref=21 /ntot=184 /MaxReadThrough="3.35114" /MaxDrop="4.38508" /score="-8.35070051" /energy="-16.3" /TU="U3090,U3091" /idTUdmin="U3091" /TUdmin="-174" /isTUend="FALSE" CDS complement(3833373..3834206) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_391787.2" /db_xref="EnsemblGenomes-Gn:BSU39080" /db_xref="EnsemblGenomes-Tr:CAB15944" /db_xref="GOA:P39805" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1H99" /db_xref="PDB:1L1C" /db_xref="PDB:1TLV" /db_xref="SubtiList:BG10474" /db_xref="UniProtKB/Swiss-Prot:P39805" /translation="MKIAKVINNNVISVVNEQGKELVVMGRGLAFQKKSGDDVDEARI EKVFTLDNKDVSEKFKTLLYDIPIECMEVSEEIISYAKLQLGKKLNDSIYVSLTDHIN FAIQRNQKGLDIKNALLWETKRLYKDEFAIGKEALVMVKNKTGVSLPEDEAGFIALHI VNAELNEEMPNIINITKVMQEILSIVKYHFKIEFNEESLHYYRFVTHLKFFAQRLFNG THMESQDDFLLDTVKEKYHRAYECTKKIQTYIEREYEHKLTSDELLYLTIHIERVVKQ A*" gene complement(3833373..3834206) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" promotor_-10 complement(3834237..3834256) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3834256) /Source="Nicolas_upshifts" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" promotor_-35 complement(3834270..3834277) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3834302..3834982) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391788.1" /db_xref="EnsemblGenomes-Gn:BSU39090" /db_xref="EnsemblGenomes-Tr:CAB15945" /db_xref="SubtiList:BG11145" /db_xref="UniProtKB/Swiss-Prot:P42307" /translation="MRRIGLCISLLVTVLVMSACESEGEAQMFADCDQKTVKQTAAKP MSSKKKQDFQALASDRQLAIVFSSMIQVSEAFDYGIGNPEYFVRISMTEEEADIAKEN LESIKLENKSLKKQNSEAVALLQKTRNQDMSRIEIQQLTENRAGFFETADSMIKLINQ VTPKNAKKTRQQLDQLKKQYTQYSAESIKIMNSIVKKQKADKASFERHLEALLQKQPG QQVRSELY*" gene complement(3834302..3834982) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" promotor_-10 complement(3835029..3835048) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-10" upshifts complement(3835038) /Source="Nicolas_upshifts" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" promotor_-35 complement(3835062..3835069) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-35" promotor_-35 3835130..3835133 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3835148..3835167 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3835148 /Source="Nicolas_upshifts" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" CDS 3835189..3836475 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12583894, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391789.1" /db_xref="EnsemblGenomes-Gn:BSU39100" /db_xref="EnsemblGenomes-Tr:CAB15946" /db_xref="GOA:P42306" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024671" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11144" /db_xref="UniProtKB/Swiss-Prot:P42306" /translation="MMKRFTKQENSWVLYDWANSAYSIVVTTAVFPLFYKSAAAESGV SAAQSTAYLGYTIAISTFILAMLGPILGTIADYEGCKKKFFGFFVSAGVASTAMLAFI PSEHWLLLLLFYTVSAIGFSGANVFYDAFLVDVTPEKRMNLVSARGFGLGYIGSTIPF IISIAVILLAQAETIPVSVSAASQLSFFITAAWWGLFTIPMIKHVHQRYYIKKEPHIV INSFKRLGQTMKRIRQYRALFLFLLAYFFYIDGVGTIITMSTSYGSDLGIGSSSLLII LFVTQVVAAPFSIIYGKLAERFTGKTMLYVGIVIYMIVCVYAYFMETTLDFWILAMLV ATSQGGIQALSRSYFAKLVPKRHANEFFGFYNIFGKFASIMGPLLIAVTAQLTGKSST AVFSLIILFVIGIVILAFVPEETSTDVSQQQNDLPL*" gene 3835189..3836475 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" promotor_-10 complement(3835920..3835938) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3835928) /Source="Nicolas_upshifts" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3835952..3835959) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3836446 /Source="Nicolas_upshifts" /id="D2036" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="2.50578" /MaxDrop="3.06646" /score="-7.45683354" /energy="-16.7" /TU="NA" /idTUdmin="U3092" /TUdmin=0 /isTUend="TRUE" CDS complement(3836494..3837933) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase for 23S ribosomal RNAmaturation" /protein_id="NP_391790.2" /db_xref="EnsemblGenomes-Gn:BSU39110" /db_xref="EnsemblGenomes-Tr:CAB15947" /db_xref="GOA:P42305" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005580" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028619" /db_xref="PDB:2G0C" /db_xref="PDB:2HJV" /db_xref="PDB:3MOJ" /db_xref="SubtiList:BG11143" /db_xref="UniProtKB/Swiss-Prot:P42305" /translation="MSHFKNYQISHDILRALEGLGYTEPTKVQQSVIPAALERKDLVV KSQTGSGKTASFGIPLCELANWDENKPQALILTPTRELAVQVKEDITNIGRFKRIKAT AVFGKSSFDKQKAELKQKSHIVVGTPGRVLDHIEKGTLPLDRLSYLVIDEADEMLNMG FIEQVEAIIKHLPTERTTMLFSATLPQDIEKLSRQYMQNPEHIEVKAAGLTTRNIEHA VIQVREENKFSLLKDVLMTENPDSCIIFCRTKEHVNQLTDELDDLGYPCDKIHGGMIQ EDRFDVMNEFKRGEYRYLVATDVAARGIDIENISLVINYDLPLEKESYVHRTGRTGRA GNKGKAISFVTAFEKRFLADIEEYIGFEIQKIEAPSQEEVARKKPEFLAKLNDRPESK KDKSEELNKDIMKLYFNGGKKKKIRAVDFVGTIAKIDGVSADDIGIITIMDNASYVEI LNGKGPHVLKVMKNTTVKGKQLKVNKANK*" gene complement(3836494..3837933) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" downshifts complement(3836517) /Source="Nicolas_upshifts" /id="D2037" /incds=0 /nref=200 /ntot=269 /MaxReadThrough="1.50578" /MaxDrop="5.83238" /score="3.28924902" /energy="-18.2" /TU="NA" /idTUdmin="U3095" /TUdmin=5 /isTUend="TRUE" misc_feature complement(3837957..3837976) /Source="Nicolas_upshift_promotors" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3837974) /Source="Nicolas_upshifts" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" CDS complement(3838015..3839163) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10746760, 25394512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="esterase (lipoprotein)" /protein_id="NP_391791.2" /db_xref="EnsemblGenomes-Gn:BSU39120" /db_xref="EnsemblGenomes-Tr:CAB15948" /db_xref="GOA:P42304" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="PDB:2O14" /db_xref="SubtiList:BG11142" /db_xref="UniProtKB/Swiss-Prot:P42304" /translation="MKKWMAAVFVMMLMLCFGGIENVKAAEPKVYQFDFGSGSMEPGY IGVRASDRYDRSKGYGFQTPENMRDVAASGAGVKSDAVQFLAYGTKSNNTFNVDLPNG LYEVKVTLGNTARASVAAEGVFQVINMTGDGAEDTFQIPVTDGQLNLLVTEGKAGTAF TLSALKIKKLSDQPVTNRTIYVGGDSTVCNYYPLNSSKQAGWGQMLPHYIDKHTFQVR NMASGGQIARGFRNDGQLEAILKYIKPGDYFMLQLGINDTNPKHKESEAEFKEVMRDM IRQVKAKGADVILSTPQGRATDFTSEGIHSSVNRWYRASILALAEEEKTYLIDLNVLS SAYFTSIGPERTLGLYMDGDTLHPNRAGADALARLAVQELKRQGIAGF*" gene complement(3838015..3839163) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" promotor_-10 complement(3839190..3839206) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3839206) /Source="Nicolas_upshifts" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" S_feature complement(3839208..3839292) /Source="Nicolas_S_feature" /locus_tag="new_4018701_4018785_c" /HighExp="T3.30H, T4.0H, T2.30H, T3.0H, T2.0H, T-3.40H, T5.0H, T-2.40H, Lbexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1508" promotor_-35 complement(3839221..3839226) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3839293..3839481) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52710.1" /translation="MRFENISASKLDDLESIDSVALEIVPTDDQWERLRYYVYDEENQ ISFYCGGWDVIKCDKKSH*" gene complement(3839293..3839481) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /pseudo CDS complement(3839512..3839643) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097796.1" /db_xref="EnsemblGenomes-Gn:BSU39139" /db_xref="EnsemblGenomes-Tr:CAX52711" /db_xref="UniProtKB/Swiss-Prot:C0H3T5" /translation="MNITQYEKLKQHLSDEDTGPFTLNEFSFYMKEDDRYIHIPVFE* " gene complement(3839512..3839643) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" CDS complement(3839655..3840116) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type f: factor" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391793.1" /db_xref="EnsemblGenomes-Gn:BSU39140" /db_xref="EnsemblGenomes-Tr:CAB15950" /db_xref="SubtiList:BG11140" /db_xref="UniProtKB/Swiss-Prot:P42302" /translation="MEITSISSIGNLDMIELKPDQTVMACELEDAESFYRFWAGLAYD RIMIQVITTGSFIEDLSEYFEGHAYKVTKLAKREFHFQSILQEADRDIADFLFLLASI NDDVFLITDPQPDKSYFSEGKLQCLTDSGERIIWFEYDAVDIYMIGGESYK*" gene complement(3839655..3840116) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" CDS complement(3840132..3840428) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391794.1" /db_xref="EnsemblGenomes-Gn:BSU39150" /db_xref="EnsemblGenomes-Tr:CAB15951" /db_xref="InterPro:IPR025551" /db_xref="SubtiList:BG11139" /db_xref="UniProtKB/Swiss-Prot:P42320" /translation="MLQKLRKRQRELEEKQYPDELYGFEAEIYEFFMLVAGSLDYVLA NKRIPRHQRRSLEKSFFELYPDILPDMIKNDKDLYHHILLYEQVRQEICVALSN*" gene complement(3840132..3840428) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" CDS complement(3840456..3840944) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391795.1" /db_xref="EnsemblGenomes-Gn:BSU39160" /db_xref="EnsemblGenomes-Tr:CAB15952" /db_xref="InterPro:IPR020323" /db_xref="SubtiList:BG11138" /db_xref="UniProtKB/Swiss-Prot:P42301" /translation="MMNWRALSQTKQDRIWSEVNKIIKWKPGSRCHHIIPPDPYRVFD ISSAMSSKAGHNDVSGVLSDLETSILKAFQLGTGKNDVMYALDWQHDGYTFSPHQAMP KDEFGEWPVPVFPNGDYYFFFHQDFSWGLLGDPWKCAITVFGEELLEAIDNDPPILFR NK*" gene complement(3840456..3840944) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" CDS complement(3840962..3841414) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391796.1" /db_xref="EnsemblGenomes-Gn:BSU39170" /db_xref="EnsemblGenomes-Tr:CAB15953" /db_xref="SubtiList:BG14170" /db_xref="UniProtKB/Swiss-Prot:O32285" /translation="MWCFTLDGQQKEIHIDRKLEEMDAPAVDDCYGLAEKNGLIYMLY YGDAVIAAFDETVVRRVWILSDKEPDSEAFDQLAISEEGFLVGTFNCYSADLKSSLYL ISADVSQEMEEITCCDSNGEGLDVQQLKLTSYAVYAVASSGVYKQDIQ*" gene complement(3840962..3841414) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" S_feature complement(3841415..3841483) /Source="Nicolas_S_feature" /locus_tag="new_4020908_4020976_c" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, T2.0H, T-3.40H, T5.0H, T-2.40H, T-4.40H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19384199999999999" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1509" CDS complement(3841484..3841813) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391797.1" /db_xref="EnsemblGenomes-Gn:BSU39180" /db_xref="EnsemblGenomes-Tr:CAB15954" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11137" /db_xref="UniProtKB/Swiss-Prot:P42300" /translation="MKKLKLNKIINENTQDCFFHADPQGRVYIGKGLKGGITITIYDP SGDVRDFRVKEQISYSDILLFQQCADGYVFVYYESYEPKVKVFSEEGRVKSVFHLPSG VSCCLLD*" gene complement(3841484..3841813) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" S_feature complement(3841814..3841935) /Source="Nicolas_S_feature" /locus_tag="new_4021307_4021428_c" /HighExp="T3.30H, T4.0H, T3.0H, T2.30H, T-4.40H, T-3.40H, LBGexp, T-2.40H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1510" CDS complement(3841936..3842352) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391798.1" /db_xref="EnsemblGenomes-Gn:BSU39190" /db_xref="EnsemblGenomes-Tr:CAB15955" /db_xref="SubtiList:BG11136" /db_xref="UniProtKB/Swiss-Prot:P42299" /translation="MTMYQTINEWVDYIDKGCSVLHLDFNVFKKELSLDIKVFEDEGE YTHKISFQNVASAYYSADVGDMRLEKIDPEEYNWQVFEMSYHPEGIGNLSNSIIPEYQ SNANFLIDMNRMLIAIEAETVRFDDQSFYAYQLNTK*" gene complement(3841936..3842352) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" CDS complement(3842403..3842771) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391799.1" /db_xref="EnsemblGenomes-Gn:BSU39200" /db_xref="EnsemblGenomes-Tr:CAB15956" /db_xref="SubtiList:BG14167" /db_xref="UniProtKB/Swiss-Prot:O32286" /translation="MVDWKPFGTYLLRKKLQYLNISTVLCILIKNHLVLEYVVIKLSE TNLIECINKIKSVLNGQTTREEVSDWAGTYVYADDPEVEDDRVWDMLILLSGIDLKDS SETYLHSTDDLNDWIKQYTE*" gene complement(3842403..3842771) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" CDS complement(3842765..3843235) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391800.1" /db_xref="EnsemblGenomes-Gn:BSU39210" /db_xref="EnsemblGenomes-Tr:CAB15957" /db_xref="SubtiList:BG11135" /db_xref="UniProtKB/Swiss-Prot:P42298" /translation="MQKRLIEKLAENKRRLLMSEIKEKLVPCAERGFTYRFADLAQSR QLLELVLSNSIPANTREVDALEKTEAKQLIWKISQSYVAYDDRDVLLFHQYSSEIGAL VCSFGKCLEHLDCLLECIEFDEGILNHSFILVEPKCQFGLCILHTEYGCELVYW*" gene complement(3842765..3843235) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" S_feature complement(3843236..3843560) /Source="Nicolas_S_feature" /locus_tag="new_4022729_4023053_c" /HighExp="T3.30H, T-2.40H, T2.30H, T3.0H, T4.0H, SMMPr, MG 120, C90, T2.0H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1511" CDS complement(3843561..3843989) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" /experiment="publication(s) with functional evidences, PMID:1529529, 16306698, 19763274, 23572593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1529529, 16306698, 19763274, 23572593; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin of WapA tRNase" /protein_id="NP_391801.1" /db_xref="EnsemblGenomes-Gn:BSU39220" /db_xref="EnsemblGenomes-Tr:CAB15958" /db_xref="SubtiList:BG10798" /db_xref="UniProtKB/Swiss-Prot:Q07836" /translation="MAKIKDDCIELELTPRRYQELDDDPFILSVFELLENKKAVVRDF SAVLLESEYKVLISGIETMIKGNQDSISLETIEPFLFLSIDQENGNYRIKIKIIFDDY KESKSNSNLFEINCNEEKLESFVTALKLNLENTKNPSKLP*" gene complement(3843561..3843989) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" CDS complement(3844051..3851055) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall-associated tRNA nuclease precursor; intercellular growth inhibitor" /protein_id="NP_391802.2" /db_xref="EnsemblGenomes-Gn:BSU39230" /db_xref="EnsemblGenomes-Tr:CAB15959" /db_xref="GOA:Q07833" /db_xref="InterPro:IPR006530" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR022385" /db_xref="InterPro:IPR031325" /db_xref="SubtiList:BG10797" /db_xref="UniProtKB/Swiss-Prot:Q07833" /translation="MKKRKRRNFKRFIAAFLVLALMISLVPADVLAKSTEEENGNRIA ADDPEETLQKEQTEEAVPFDPKDINKEGEITSERTENTKLYYEGDGVYKQEVYLDPIH TKETPDADWEDISPELKESTSKQVETENAILNSDFQKQMKNGLYATFEHNDHKVTYSL AEAKGPNKTSLTPKDTSADYKTDSNEIVYPDVFPNIDLQTFTFNENIKEDLVLHQYNG YNTFTFQLKTDLQAKEQEDGSIDFSDEKGKVVFSVPKPFMTDSKLDELSGEVERSDKV SYKLEKNEEGYLLHLTADENWLKDPERVYPVSIDPSTSLSVSSDTFVMSAYPTTNYSA SSQKWDANLKAYVLKTGYYDKTTGTNYAFMKFNNLKPIQNMTVTKATLKTYVAHSYYG TKATGLWLDTVNSNYDNAKVTWNTKPASKNIGKADVHKGQWASYDVTAAVKSWNSGGA NYGFKLHTNGNGKEYWKKLISSANSANKPYIEVTYTIPKGNTPTIKAYHNGDSTGYFD ISWKKVEGAKGYKVWIYNGKEYQAISAGNVTSWSTKGKKIWPTSAEIASKRYKLHLDG KDGAELALDPSPVYKNSGGSYATSKNYWIGVSAIFDQGEGAMSAPAKPVIPNVGKAQA PSAKGYNNGNATGYFDLSWKAVSGATGYKVQVFNGKGFETLDLGNQTSWTTKGKKIWP TSAEIKAGKYALHLKDGSGAELPINPGPTYKNAGGDGAKRNYSFKIIAYNKDGEAIAS PAATPALPDIARPKNVTGYLYTNTKSSQTGYVNLIWEKVQNAKGYKVNIYNGKEYQSF DVGDADHWTTQNKNIWPTSEEIKAGSYKLHTDGKGGELALDPSPVYNNANGNYKGKKN YSFTLVAYDANGETIPTAPFNPTFHEGAEFLGTEEYWSIIDIPSGQLNGATGNVIVNE EDLSIDGRGPGLGLSRTYNSLDSSDHLFGQGWYADAETSVISTDGGAMYIDEDATTHR FTKKADGTYQPPTGVYLELTETADQFILKTKDQTNAYFNKKGGKLQKVVDGHNNATVY TYNDKNQLTAITDASGRKLTFTYDENGHVTSITGPKNKKVTYSYENDLLKKVTDTDGT VTSYDYDSEGRLVKQYSANSTEAKPVFTEYQYSGHRLEKAINAKKETYVYSYDADKKT LLMTQPNGRKVQYGYNEAGNPIQVIDDAEGLKITTNTKYEGNNVVEDVDPNDVGTGKA TESYQYDKDGNVTSVKDAYGTETYEYNKNNDVTKMKDTEGNVTDIAYDGLDAVSETDQ SGKSSSAAVYDKYGNQIQSSKDLSASTNILKDGSFEAQKSGWNLTASKDSGKISVIAD KSGVLSGSKALEVLSQSTSAGTDHGYSSATQTVELEPNTTYTLSGKIKTDLAKSRAYF NIDLRDKDQKRIQWIHNEYSALAGKNDWTKRQITFTTPANAGKAVVYMEVDHKDKDGK GKAWFDEVQLEKGEVSSSYNPVQNSSFTSATENWNVSGASVDSEEGFNDDVSLKAART SASQAGSVTKQTVVLGQSANDKPVYLTLTGMSKASSVKFTDEKDYSLQANVTYADGST GIYNAKFPSGTQEWNRAAVVIPKTKPINKVDISILFQKSATGTVWFDDIRLIEGSLLT KSTYDSNGNYVTKEEDELGYATSTDYDETGKKTSETDAKGEKTTYTYDQADQLTNMTL SNGTSILHSYDKEGNEVSKTIRAGADQTYKFEYDVMGKLVKTTDPLGNVLASEYDANS NLTKTISPNGNEVSLSYDGTDRVKSKSYNGTEKYIFTYDKNGNETSVVNKEQNTTKKR TFDNKNRLTELTDRGGSQTWTYPSDSDKLKTFSWIHGDQKGTNQFTYNKLDQMIEMKD STSSYSFDYDENGNVQTFITGNGGGTSFSYDERNLVSSLHIGDKNGGDILTESYEYDA NGNRTTINSSASGKVQYEYGKLNQLVKETHEDGTVIEYTYDGFGNRKTVTTIKDGSSK TVNASFNIMNQLTKVNDESISYDKNGNRTSDGKFTYTWDAEDNLTAVTKKGEDKPFAT YKYDEKGNRIQKTVNGKVTNYFYDGDSLNVLYETDADNNVTKSYTYGDSGQLLSYTEN GKKYFYHYNAHGDIIAISDSTGKTVAKYQYDAWGNPTKTEASDEVKDNRYRYAGYQYD EETGLYYLMARYYEPRNGVFLSLDPDPGSDGDSLDQNGYAYGNNNPVMNVDPDGHWVW LVVNAGFAAYDGYKAYKSGKGWKGAAWAAASNFGPGKIFKGASRAYKFTKKAVKITGH TRHGLNQSIGRNGGRGVNLRAKLNAVRSPKKVIKQPNGATKYVGKKATVVLNKRGKVI TAYGSSRAKGSKHVFHTHGKGNKSKRRR*" gene complement(3844051..3851055) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" misc_feature 3851062..3851076 /Source="Nicolas_upshift_promotors" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3851076 /Source="Nicolas_upshifts" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3851086..3851105) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3851101) /Source="Nicolas_upshifts" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" promotor_-35 complement(3851120..3851127) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3851217..3852152) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391803.1" /db_xref="EnsemblGenomes-Gn:BSU39240" /db_xref="EnsemblGenomes-Tr:CAB15960" /db_xref="GOA:Q07835" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10796" /db_xref="UniProtKB/Swiss-Prot:Q07835" /translation="MQQDPSISSKQKSTAVIKMVISMVIFGSIGFFSEHTNLPSFELV FVRCLCATLFLGFCWLASGQYKTEKWSKRDVLQTLACGFFLVFNWVFLFKSFEETSVT IAISVYHLAPVLVLLLGSFFYREKLNVISVSSIIICFLGTALISGINGSTSLTQLMGS GIIWAVLAALFYAFTTLLGKGIHNLSPYTTTFLQTGLGVIILIPFIHFGAFADLSQGN WIMVVSTGIIHTGIVYLLFFDSLRFLSTKFISIIVFLDPAVAIVLDTVFTGFRPDLYQ TLGIVMIFAGMALTLVRRQGKANVTAEGTDIEQIQ*" gene complement(3851217..3852152) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" downshifts complement(3851438) /Source="Nicolas_upshifts" /id="D2038" /incds=1 /nref=1 /ntot=153 /MaxReadThrough="1.33481" /MaxDrop="2.42407" /score="29.0290332" /energy="-5.9" /TU="NA" /idTUdmin="U3098" /TUdmin=22 /isTUend="TRUE" S_feature complement(3852153..3852273) /Source="Nicolas_S_feature" /locus_tag="new_4031646_4031766_c" /HighExp="T3.0H, T1.0H, T3.30H, LBGstat, T1.30H, T0.30H, T4.0H, M9-stat, T2.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="Sig-" /TUlongPSig="0.196" /label="S1512" CDS complement(3852304..3852750) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10913081, 12644671, 17210127" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 12644671, 17210127; Product type f: factor" /codon_start=1 /transl_table=11 /product="phosphate starvation protein (universal stress protein A family)" /protein_id="NP_391804.1" /db_xref="EnsemblGenomes-Gn:BSU39250" /db_xref="EnsemblGenomes-Tr:CAB15961" /db_xref="GOA:P42297" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11134" /db_xref="UniProtKB/Swiss-Prot:P42297" /translation="MFNKMLVAIDGSDMSAKALDAAVHLAKEQQAELSILHVGREAVV TTSSLTGIVYVPEHFIDEIRNEVKKEGLKILENAKEKAAEKGVQAETIYANGEPAHEI LNHAKEKGVSLIVVGSRGISGLKEMMLGSVSHKVSQLSTCPVLIVR*" gene complement(3852304..3852750) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" downshifts complement(3852318) /Source="Nicolas_upshifts" /id="D2039" /incds=0 /nref=22 /ntot=144 /MaxReadThrough="4.33955" /MaxDrop="6.75522" /score="45.6082379" /energy="-8.4" /TU="U3098" /idTUdmin="U3099" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3852787..3852806) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3852794) /Source="Nicolas_upshifts" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" promotor_-35 complement(3852820..3852827) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3852853..3854262) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_391805.2" /db_xref="EnsemblGenomes-Gn:BSU39260" /db_xref="EnsemblGenomes-Tr:CAB15962" /db_xref="GOA:P40740" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG10935" /db_xref="UniProtKB/Swiss-Prot:P40740" /translation="MSSNEKRFPEGFLWGGAVAANQVEGAYNEGGKGLSTADVSPNGI MSPFDESMTSLNLYHNGIDFYHRYKEDIALFAEMGFKAFRTSIAWTRIFPNGDEEEPN EEGLRFYDDLFDELLKHHIEPVVTISHYEMPLGLVKNYGGWKNRKVIEFYERYAKTVF KRYQHKVKYWMTFNEINVVLHAPFTGGGLVFEEGENKLNAMYQAAHHQFVASALAVKA GHDIIPDSKIGCMIAATTTYPMTSKPEDVFAAMENERKTLFFSDVQARGAYPGYMKRY LAENNIEIEMAEGDEELLKEHTVDYIGFSYYMSMAASTDPEELAKSGGNLLGGVKNPY LKSSEWGWQIDPKGLRITLNTLYDRYQKPLFIVENGLGAVDKVEEDGTIQDDYRINYL RDHLIEAREAIADGVELIGYTSWGPIDLVSASTAEMKKRYGFIYVDRDNEGNGTFNRI KKKSFNWYQQVIATNGESL*" gene complement(3852853..3854262) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" CDS complement(3854285..3856114) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" /EC_number="2.7.1.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17074746, 8626332" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17074746, 8626332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) beta-glucoside-specific enzyme IIBCA component" /protein_id="NP_391806.2" /db_xref="EnsemblGenomes-Gn:BSU39270" /db_xref="EnsemblGenomes-Tr:CAB15963" /db_xref="GOA:P40739" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011297" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10934" /db_xref="UniProtKB/Swiss-Prot:P40739" /translation="MDYDKLSKDILQLVGGEENVQRVIHCMTRLRFNLHDNAKADRSQ LEQLPGVMGTNISGEQFQIIIGNDVPKVYQAIVRHSNLSDEKSAGSSSQKKNVLSAVF DVISGVFTPILPAIAGAGMIKGLVALAVTFGWMAEKSQVHVILTAVGDGAFYFLPLLL AMSAARKFGSNPYVAAAIAAAILHPDLTALLGAGKPISFIGLPVTAATYSSTVIPILL SIWIASYVEKWIDRFTHASLKLIVVPTFTLLIVVPLTLITVGPLGAILGEYLSSGVNY LFDHAGLVAMILLAGTFSLIIMTGMHYAFVPIMINNIAQNGHDYLLPAMFLANMGQAG ASFAVFLRSRNKKFKSLALTTSITALMGITEPAMYGVNMRLKKPFAAALIGGAAGGAF YGMTGVASYIVGGNAGLPSIPVFIGPTFIYAMIGLVIAFAAGTAAAYLLGFEDVPSDG SQQPAVHEGSREIIHSPIKGEVKALSEVKDGVFSAGVMGKGFAIEPEEGEVVSPVRGS VTTIFKTKHAIGITSDQGAEILIHIGLDTVKLEGQWFTAHIKEGDKVAPGDPLVSFDL EQIKAAGYDVITPVIVTNTDQYSFSPVKEIGKVQPKEALLALS*" gene complement(3854285..3856114) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" promotor_no_box complement(3856106..3856206) /Source="Nicolas_upshift_promotors" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" /label="promotor_no_box" upshifts complement(3856146) /Source="Nicolas_upshifts" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" S_feature complement(3856148..3856340) /Source="Nicolas_S_feature" /locus_tag="new_4035641_4035833_c" /HighExp="Diami, T0.30H, B60, T0.0H, G150, M9-stat, T1.0H, T1.30H, Gly, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29980099999999998" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.998, 0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1513" promotor_-10 complement(3856321..3856340) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3856340) /Source="Nicolas_upshifts" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" S_feature complement(3856342..3856475) /Source="Nicolas_S_feature" /locus_tag="new_4035835_4035968_c" /HighExp="S2, HiTm, Sw, S8, M9-stat, Lbstat, S0, T2.0H, Mal, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1514" promotor_-35 complement(3856353..3856360) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3856497..3856805) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391807.1" /db_xref="EnsemblGenomes-Gn:BSU39280" /db_xref="EnsemblGenomes-Tr:CAB15964" /db_xref="SubtiList:BG11071" /db_xref="UniProtKB/Swiss-Prot:P40738" /translation="MLLINKQKDPVFQFLAGTFHQDIETPDDAIQELLIEESKEYLED AIVFLTDFIESEHSDNKKNDYIQSCADGVYLPAFNLEPIDWLKNVIVQIKKSLKKFKR *" gene complement(3856497..3856805) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" downshifts complement(3856520) /Source="Nicolas_upshifts" /id="D2040" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.99098" /MaxDrop="5.76651" /score="24.0715465" /energy="-21.3" /TU="U3101,U3102" /idTUdmin="U3101" /TUdmin="-3718" /isTUend="FALSE" CDS complement(3856851..3857294) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin factor of the RttD-RttE toxin-antitoxin system" /protein_id="NP_391808.1" /db_xref="EnsemblGenomes-Gn:BSU39290" /db_xref="EnsemblGenomes-Tr:CAB15965" /db_xref="InterPro:IPR018958" /db_xref="SubtiList:BG11070" /db_xref="UniProtKB/Swiss-Prot:P40737" /translation="MSYNFIKSNKENDFYPVNQSEIEEVEKNLNLKLPSELVNFYLEV GYGFIKGSEFNTNRILDPYSVRDFRLRINDFEFYPDIEIYDEFENDKLIFFEGSESAL MSIELNDNNKNPIYYYDIQIATSLTEFLRKIEENDQYYLDLLDDE*" gene complement(3856851..3857294) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" CDS complement(3857291..3859000) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease toxin of the RtbD-RtbE toxin-antitoxin system" /protein_id="NP_391809.2" /db_xref="EnsemblGenomes-Gn:BSU39300" /db_xref="EnsemblGenomes-Tr:CAB15966" /db_xref="GOA:P42296" /db_xref="InterPro:IPR003615" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG11133" /db_xref="UniProtKB/Swiss-Prot:P42296" /translation="MKTLDVHALHEGIQHTIEKLDKQKQQLEKLEKSVEHLAGMKDAL KGKGGDAIRTFYEECHKPFLLFFGIFIDEYKKVLKQTQHAISSVESNSHGMIAEAFLS HDARHGVKHAREVTEQLTDAVNRQTSAIDHIVSLPTVNDSFFRMETEQAERLISDTLN KLFQFDGQQTQALEAAKSDFQTMKKYIDQLETMYTGPKIEITGYKSGSILKSQEEENI NQIFGAINPQMKQADDSPMEMMLKKLAENEKSKVDSVVKTGDSKKVSKNIIVINGKVY NTSEHREHIKTDFSNAEVKQVVYNDTLYNVYISGNDMKLEPVVSLSDIKVDENGYVKI LETAVELTGVYDLFKAATGRDPVSGEKVTGKDRVVASINSVPFAKIAKLEKLIDINKL INNGKKAKKASEVKNVAKDKGKIANDVSGSANKINSDLIKKYARDIEQRTGRELPKNQ IDKLKEALRNKEYKKMSPIETAKHRTKFDKVKNKVIKEWEENTGQKWPVYKENVVSEK TGKIIRKKGDKYDAHHIIENTFGGEHEWWNMHPAKFPNEHQAGIHGTGSPANELFKGG KKK*" gene complement(3857291..3859000) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" misc_feature complement(3858162..3858181) /Source="Nicolas_upshift_promotors" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3858170) /Source="Nicolas_upshifts" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" CDS complement(3859020..3859289) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391810.1" /db_xref="EnsemblGenomes-Gn:BSU39310" /db_xref="EnsemblGenomes-Tr:CAB15967" /db_xref="InterPro:IPR020315" /db_xref="SubtiList:BG11132" /db_xref="UniProtKB/Swiss-Prot:P42295" /translation="MAQEIKMVYDTVKQGLSQLKNSAELKSSLPGHLSGRNHLNVVKS IEQLNKDIKELTEAYASVLAKHIAQTESAVNAMKETDENISSSMK*" gene complement(3859020..3859289) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" CDS complement(3859301..3859666) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391811.1" /db_xref="EnsemblGenomes-Gn:BSU39320" /db_xref="EnsemblGenomes-Tr:CAB15968" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG11131" /db_xref="UniProtKB/Swiss-Prot:P42294" /translation="MHSEMLLHSVKADLHEKQEQIHQLKRVLHEIRQIKHDFSEAQHL IHRPHLNREAWRGTHAERFEDIREGMNKAYQQIKSDQVSGIIESIEGKIHSLEGDVYS IRRQITRIEHEIEKEKHKK*" gene complement(3859301..3859666) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" S_feature complement(3859667..3859732) /Source="Nicolas_S_feature" /locus_tag="new_4039160_4039225_c" /HighExp="T-1.40H, T-3.40H, T2.30H, T-2.40H, T-0.40H, T1.0H, T-1.10H, T-5.40H, T3.30H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1515" promotor_-10 complement(3859719..3859738) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3859732) /Source="Nicolas_upshifts" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" promotor_-35 complement(3859753..3859756) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3859973..3861382) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 18408032, 18607095, 20883454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 18408032, 18607095, 20883454; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan endo-1,5-alpha-L-arabinosidase ([Ca(2+)-dependent]" /protein_id="NP_391812.2" /db_xref="EnsemblGenomes-Gn:BSU39330" /db_xref="EnsemblGenomes-Tr:CAB15969" /db_xref="GOA:P42293" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR023296" /db_xref="InterPro:IPR032291" /db_xref="PDB:2X8F" /db_xref="PDB:2X8S" /db_xref="PDB:2X8T" /db_xref="PDB:4COT" /db_xref="SubtiList:BG11130" /db_xref="UniProtKB/Swiss-Prot:P42293" /translation="MFNRLFRVCFLAALIMAFTLPNSVYAQKPIFKEVSVHDPSIIET NGTFYVFGSHLASAKSNDLMQWQQLTTSVSNDNPLIPNVYEELKETFEWAQSDTLWAA DVTQLADGKYYMYYNACRGDSPRSAMGVAVADNIEGPYKNKGIFLKSGMEGTSSDGTP YDATKHPNVVDPHTFFDKDGKLWMVYGSYSGGIFILEMNPKTGFPLPGQGYGKKLLGG NHSRIEGPYVLYNPDTQYYYLYLSYGGLDATGGYNIRVARSKKPDGPYYDAEGNPMLD VRGKGGTFFDDRSIEPYGVKLMGSYTFETENEKGTGYVSPGHNSAYYDEKTGRSYLIF HTRFPGRGEEHEVRVHQLFMNKDGWPVAAPYRYAGETLKEVKQKDITGTYKLIQHGKD ISADIKQTINIQLNKNHTISGEMTGTWRKTGKNTADITLAGKKYNGVFLRQWDSVREK NVMTFSVLNTSGEAVWGSK*" gene complement(3859973..3861382) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" downshifts complement(3859996) /Source="Nicolas_upshifts" /id="D2041" /incds=0 /nref=2 /ntot=38 /MaxReadThrough="0.825980000000001" /MaxDrop="3.49689" /score="16.962389" /energy="-7.9" /TU="NA" /idTUdmin="U3101" /TUdmin="-7194" /isTUend="FALSE" S_feature complement(3861383..3861492) /Source="Nicolas_S_feature" /locus_tag="new_4040876_4040985_c" /HighExp="S2, T2.30H, BC, T2.0H, M9-stat, T3.0H, T3.30H, T4.0H, S1, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1516" CDS complement(3861516..3861680) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097797.1" /db_xref="EnsemblGenomes-Gn:BSU39339" /db_xref="EnsemblGenomes-Tr:CAX52712" /db_xref="UniProtKB/Swiss-Prot:C0H3T6" /translation="MAVSQLMQNLTKQLLHVRERKTDVMQEGETAKELNYEGEDMQAT SSAQNRQTSV*" gene complement(3861516..3861680) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" promotor_-10 complement(3861565..3861583) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3861580) /Source="Nicolas_upshifts" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3861594..3861602) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3861872..3861891) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3861888) /Source="Nicolas_upshifts" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3861904..3861911) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3861920..3861927 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3861942..3861961 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3861945 /Source="Nicolas_upshifts" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" CDS 3861999..3862445 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391813.2" /db_xref="EnsemblGenomes-Gn:BSU39340" /db_xref="EnsemblGenomes-Tr:CAB15970" /db_xref="GOA:P10943" /db_xref="InterPro:IPR015111" /db_xref="InterPro:IPR023552" /db_xref="InterPro:IPR036482" /db_xref="PDB:1VEA" /db_xref="PDB:1WMQ" /db_xref="PDB:1WPS" /db_xref="PDB:1WPT" /db_xref="PDB:1WPU" /db_xref="PDB:1WPV" /db_xref="PDB:1WRN" /db_xref="PDB:1WRO" /db_xref="PDB:1WRQ" /db_xref="PDB:3BOY" /db_xref="PDB:4H4L" /db_xref="SubtiList:BG10666" /db_xref="UniProtKB/Swiss-Prot:P10943" /translation="MTLHKERRIGRLSVLLLLNEAEESTQVEELERDGWKVCLGKVGS MDAHKVVAAIETASKKSGVIQSEGYRESHALYHATMEALHGVTRGEMLLGSLLRTVGL RFAVLRGNPYESEAEGDWIAVSLYGTIGAPIKGLEHETFGVGINHI*" gene 3861999..3862445 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" downshifts 3862450 /Source="Nicolas_upshifts" /id="D2042" /incds=0 /nref=157 /ntot=226 /MaxReadThrough="6.10706" /MaxDrop="5.43744" /score="3.19376411" /energy="-17.8" /TU="U3105" /idTUdmin="U3105" /TUdmin="-7018" /isTUend="FALSE" CDS 3862558..3864084 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" /EC_number="4.3.1.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9535092, 10220322, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidine ammonia-lyase (histidase)" /protein_id="NP_391814.1" /db_xref="EnsemblGenomes-Gn:BSU39350" /db_xref="EnsemblGenomes-Tr:CAB15971" /db_xref="GOA:P10944" /db_xref="InterPro:IPR001106" /db_xref="InterPro:IPR005921" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR022313" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10667" /db_xref="UniProtKB/Swiss-Prot:P10944" /translation="MVTLDGSSLTTADVARVLFDFEEAAASEESMERVKKSRAAVERI VRDEKTIYGINTGFGKFSDVLIQKEDSAALQLNLILSHACGVGDPFPECVSRAMLLLR ANALLKGFSGVRAELIEQLLAFLNKRVHPVIPQQGSLGASGDLAPLSHLALALIGQGE VFFEGERMPAMTGLKKAGIQPVTLTSKEGLALINGTQAMTAMGVVAYIEAEKLAYQTE RIASLTIEGLQGIIDAFDEDIHLARGYQEQIDVAERIRFYLSDSGLTTSQGELRVQDA YSLRCIPQVHGATWQTLGYVKEKLEIEMNAATDNPLIFNDGDKVISGGNFHGQPIAFA MDFLKIAISELANIAERRIERLVNPQLNDLPPFLSPHPGLQSGAMIMQYAAASLVSEN KTLAHPASVDSIPSSANQEDHVSMGTIAARHAYQVIANTRRVIAIEAICALQAVEYRG IEHAASYTKQLFQEMRKVVPSIQQDRVFSYDIERLTDWLKKESLIPDHQNKELRGMNI *" gene 3862558..3864084 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" CDS 3864081..3865739 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" /EC_number="4.2.1.49" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15313616, 17395359, 22933560; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urocanase" /protein_id="NP_391815.1" /db_xref="EnsemblGenomes-Gn:BSU39360" /db_xref="EnsemblGenomes-Tr:CAB15972" /db_xref="GOA:P25503" /db_xref="InterPro:IPR023636" /db_xref="InterPro:IPR023637" /db_xref="InterPro:IPR035085" /db_xref="InterPro:IPR035400" /db_xref="InterPro:IPR035401" /db_xref="InterPro:IPR036190" /db_xref="PDB:2FKN" /db_xref="SubtiList:BG10668" /db_xref="UniProtKB/Swiss-Prot:P25503" /translation="MTDVKKSIRANRGTELECLGWEQEAVLRMLRNNLDPEVAEKPED LIVYGGIGKAARDWDAFHAIEHSLKTLKNDETLLVQSGKPVGMFRTHPQAPRVLLANS VLVPKWADWEHFHELEKKGLMMYGQMTAGSWIYIGSQGILQGTYETFAELARQHFGGS LKGTLTLTAGLGGMGGAQPLSVTMNEGVVIAVEVDEKRIDKRIETKYCDRKTASIEEA LAWAEEAKLAGKPLSIALLGNAAEVHHTLLNRGVKIDIVTDQTSAHDPLIGYVPEGYS LDEADRLRQDTPELYVRLAKQSMKKHVEAMLAFQQKGSIVFDYGNNIRQVAKDEGLEN AFDFPGFVPAYIRPLFCEGKGPFRWAALSGDPADIYRTDALLKELFPTNKALHRWIDM AQEKVTFQGLPSRICWLGYGERKKMGLAINELVRTGELKAPVVIGRDHLDCGSVASPN RETEAMKDGSDAVGDWAVLNALVNTAAGASWVSFHHGGGVGMGYSLHAGMVAVADGSE LADERLARVLTSDPGMGIIRHADAGYERAVEVAKEQDIIVPMQK*" gene 3864081..3865739 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" CDS 3865752..3867017 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" /EC_number="3.5.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16990261, 17395359, 18296777" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16990261, 17395359, 18296777; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazolone-5-propionate hydrolase" /protein_id="NP_391816.1" /db_xref="EnsemblGenomes-Gn:BSU39370" /db_xref="EnsemblGenomes-Tr:CAB15973" /db_xref="GOA:P42084" /db_xref="InterPro:IPR005920" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2BB0" /db_xref="PDB:2G3F" /db_xref="SubtiList:BG11100" /db_xref="UniProtKB/Swiss-Prot:P42084" /translation="MPKQIDTILINIGQLLTMESSGPRAGKSMQDLHVIEDAVVGIHE QKIVFAGQKGAEAGYEADEIIDCSGRLVTPGLVDPHTHLVFGGSREKEMNLKLQGISY LDILAQGGGILSTVKDTRAASEEELLQKAHFHLQRMLSYGTTTAEVKSGYGLEKETEL KQLRVAKKLHESQPVDLVSTFMGAHAIPPEYQNDPDDFLDQMLSLLPEIKEQELASFA DIFTETGVFTVSQSRRYLQKAAEAGFGLKIHADEIDPLGGAELAGKLKAVSADHLVGT SDEGIKKLAEAGTIAVLLPGTTFYLGKSTYARARAMIDEGVCVSLATDFNPGSSPTEN IQLIMSIAALHLKMTAEEIWHAVTVNAAYAIGKGEEAGQLKAGRSADLVIWQAPNYMY IPYHYGVNHVHQVMKNGTIVVNREGAILG*" gene 3865752..3867017 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" CDS 3867010..3867969 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" /EC_number="3.5.3.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931887, 15355972, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formiminoglutamate hydrolase" /protein_id="NP_391817.1" /db_xref="EnsemblGenomes-Gn:BSU39380" /db_xref="EnsemblGenomes-Tr:CAB15974" /db_xref="GOA:P42068" /db_xref="InterPro:IPR005923" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="PDB:3M1R" /db_xref="SubtiList:BG11099" /db_xref="UniProtKB/Swiss-Prot:P42068" /translation="MDKYPFLREAGSSFKDRDVTKMSDLIATWDGQDIKGPALIGVPL SKSSISHSGASFAPGTIRQALKHSSAYSAELGEHVVSELLYDLGDIDIHVTDIVKSHH HIFQTMHALLSDHPDWVPLILGGDNSISYSTIKAIAQTKGTTAVIQFDAHHDVRNTED GGPTNGTPFRRLLDEEIIEGQHLIQLGIREFSNSQAYEAYAKKHNVNIHTMDMIREKG LIPTIKEILPVVQDKTDFIFISVDMDVLDQSHAPGCPAIGPGGLYTDELLEAVKYIAQ QPNVAGIEIVEVDPTLDFRDMTSRAAAHVLLHALKGMKLSPFK*" gene 3867010..3867969 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" S_feature 3867970..3868044 /Source="Nicolas_S_feature" /locus_tag="new_4047463_4047537" /HighExp="Sw, BC, T3.30H, T4.0H, T5.0H, T3.0H, T2.30H, S8, M9-stat, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1517" CDS 3868045..3869472 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="histidine degradation metabolites permease" /protein_id="NP_391818.2" /db_xref="EnsemblGenomes-Gn:BSU39390" /db_xref="EnsemblGenomes-Tr:CAB15975" /db_xref="GOA:P42087" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11101" /db_xref="UniProtKB/Swiss-Prot:P42087" /translation="MNLQENSSQQLKRTMKSRHLFMISLGGVIGTGLFLSTGYTLHQA GPGGTILAYVIGGLMMYLVMQCLGELSVAMPVTGSFQKYATTFIGPSTGFMVGIMYWI NWVVTVGSEFTASGILMQRWFPDSSVWMWSAIFAALLFICNAFSVKLFAETEFWFSSV KIVTIILFIILGGAAMFGLISLNGTADAPMLSNFTDHGGLFPNGFLAVFIAMISVSFA FSGTELIGVTAGESANPQKDIPRSIRNVAWRTVIFFIGAVFILSGLISWKDAGVIESP FVAVFAEIGIPYAADIMNFVILTALLSVANSGLYASTRMMWSLANENMISSRFKKVTS KGIPLNALMISMAVSCLSLVSSIVAPGTVYVVMVAIAGFAGVVVWMSIALSQLLFRKR FLKKGGDVKDLTFRTPLYPLMPIAALLLCSASCIGLAFDPNQRIALFCGVPCIILCYL IYHFKRNVTKAKKISQEEYPADHIL*" gene 3868045..3869472 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" downshifts 3869468 /Source="Nicolas_upshifts" /id="D2043" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="0.7432" /MaxDrop="6.18816" /score="8.21347356" /energy="-11.7" /TU="NA" /idTUdmin="U3105" /TUdmin=0 /isTUend="TRUE" CDS complement(3869516..3870817) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" /EC_number="2.4.2.2" /EC_number="2.4.2.3" /EC_number="2.4.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 15530033, 16469506, 21707079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 15530033, 16469506, 21707079; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside phosphorylase" /protein_id="NP_391819.2" /db_xref="EnsemblGenomes-Gn:BSU39400" /db_xref="EnsemblGenomes-Tr:CAB15976" /db_xref="GOA:P39142" /db_xref="InterPro:IPR000053" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR013102" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR017872" /db_xref="InterPro:IPR018090" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="InterPro:IPR036566" /db_xref="PDB:5EP8" /db_xref="SubtiList:BG10985" /db_xref="UniProtKB/Swiss-Prot:P39142" /translation="MRMVDIIIKKQNGKELTTEEIQFFVNGYTDGSIPDYQASALAMA IFFQDMSDRERADLTMAMVNSGETIDLSAIEGIKVDKHSTGGVGDTTTLVLAPLVAAL DVPVAKMSGRGLGHTGGTIDKLEAIMGFHVELTKDEFIKLVNRDKVAVIGQSGNLTPA DKKLYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAAELA KAMVRIGNNVGRQTMAVISDMSQPLGFAIGNALEVKEAIDTLKGEGPEDLHELVLTLG SQMVVLAKKADTLDEARAKLEEVMKNGKALEKFKDFLKNQGGDSSIVDDPSKLPQAAY QIDVPAKEAGVVSEIVADEIGVAAMLLGAGRATKEDEIDLAVGIMLRKKVGDKVEKGE PLVTLYANRENVDEVIAKVYDNIRIAAEAKAPKLIHTLITE*" gene complement(3869516..3870817) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" downshifts complement(3869533) /Source="Nicolas_upshifts" /id="D2044" /incds=0 /nref=122 /ntot=224 /MaxReadThrough="1.27022" /MaxDrop="5.60021" /score="14.0361257" /energy="-13.1" /TU="NA" /idTUdmin="U3107" /TUdmin="-11" /isTUend="TRUE" CDS complement(3870847..3872028) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8550462, 11065368, 12591866, 15849754, 16850406, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 11065368, 12591866, 15849754, 16850406, 25890046; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside Na+(H+) cotransporter" /protein_id="NP_391820.2" /db_xref="EnsemblGenomes-Gn:BSU39410" /db_xref="EnsemblGenomes-Tr:CAB15977" /db_xref="GOA:P39141" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG10984" /db_xref="UniProtKB/Swiss-Prot:P39141" /translation="MKYLIGIIGLIVFLGLAWIASSGKKRIKIRPIVVMLILQFILGY ILLNTGIGNFLVGGFAKGFGYLLEYAAEGINFVFGGLVNADQTTFFMNVLLPIVFISA LIGILQKWKVLPFIIRYIGLALSKVNGMGRLESYNAVASAILGQSEVFISLKKELGLL NQQRLYTLCASAMSTVSMSIVGAYMTMLKPEYVVTALVLNLFGGFIIASIINPYEVAK EEDMLRVEEEEKQSFFEVLGEYILDGFKVAVVVAAMLIGFVAIIALINGIFNAVFGIS FQGILGYVFAPFAFLVGIPWNEAVNAGSIMATKMVSNEFVAMTSLTQNGFHFSGRTTA IVSVFLVSFANFSSIGIIAGAVKGLNEKQGNVVARFGLKLLYGATLVSFLSAAIVGLI Y*" gene complement(3870847..3872028) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" S_feature complement(3872029..3872108) /Source="Nicolas_S_feature" /locus_tag="new_4051522_4051601_c" /HighExp="G150, G135, Oxctl, G180, Mt0, M40t45, Lbtran, M0t90, M40t90, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1518" CDS complement(3872109..3872780) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" /EC_number="4.1.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 27033207" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 27033207; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyribose-phosphate aldolase" /protein_id="NP_391821.2" /db_xref="EnsemblGenomes-Gn:BSU39420" /db_xref="EnsemblGenomes-Tr:CAB15978" /db_xref="GOA:P39121" /db_xref="InterPro:IPR002915" /db_xref="InterPro:IPR011343" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR028581" /db_xref="SubtiList:BG10983" /db_xref="UniProtKB/Swiss-Prot:P39121" /translation="MSLANIIDHTALKPHTQKADILKLIEEAKTYKFASVCVNPTWVE LAAKELKGTGVDVCTVIGFPLGANTTETKAFETKDAISKGATEVDMVINIAALKDKED DVVEADIRGVVEAVAGKALVKVIIETCLLTDEEKERACRLAVSAGADFVKTSTGFSTG GATKEDIALMRKTVGPDIGVKASGGVRTKEDVDTMVEAGASRIGASAGVSIVKGENAS GGDNY*" gene complement(3872109..3872780) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" promotor_-35 3872729..3872732 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3872747 /Source="Nicolas_upshifts" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 3872748..3872767 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3872808..3872827) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3872823) /Source="Nicolas_upshifts" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" promotor_-35 complement(3872841..3872848) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3872886..3873827) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 10714997, 24863636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 10714997, 24863636; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of pyrmidine deoxyribonucleosides degradation (DeoR-dR5P)" /protein_id="NP_391822.1" /db_xref="EnsemblGenomes-Gn:BSU39430" /db_xref="EnsemblGenomes-Tr:CAB15979" /db_xref="GOA:P39140" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR013324" /db_xref="PDB:4OQP" /db_xref="PDB:4OQQ" /db_xref="SubtiList:BG10982" /db_xref="UniProtKB/Swiss-Prot:P39140" /translation="MDREKQQLSIEAARLYYQSDYSQQQIAEQLNISRPTVSRLLQYA KEKGYVQIRVMDPFEDLDALGSILEEKYGLLEAHVVFSPTPDYAGITHDLSRYGAEYM HETVKDGDIVGVSWGTTMYQIAQNMQPKQVKGVEVVQLKGGISHSRVNTYSAETIQLF AEAFQTMPRYLPLPVVFDNADVKRMVEKDRHIERIIEMGKQANIALFTVGTVRDEALL FRLGYFNEEEKALLKKQAVGDICSRFFDAKGNICSSAINDRTIGVELQDLRLKERSIL VAGGSRKVSSIHGALTGKYANVLIIDQHTARALVNDL*" gene complement(3872886..3873827) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" promotor_-10 complement(3873872..3873891) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3873878) /Source="Nicolas_upshifts" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" S_feature complement(3873880..3873960) /Source="Nicolas_S_feature" /locus_tag="new_4053373_4053453_c" /HighExp="Etha, Diami, Salt, MG 10, Gly, MG 60, G180, GM 60, G135, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.55204399999999998" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1519" promotor_-35 complement(3873907..3873910) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3873961..3874788) /gene="yxxB" /locus_tag="BSU_39440" /old_locus_tag="BSU39440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10746760, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391823.2" /db_xref="EnsemblGenomes-Gn:BSU39440" /db_xref="EnsemblGenomes-Tr:CAB15980" /db_xref="GOA:P39139" /db_xref="InterPro:IPR009597" /db_xref="SubtiList:BG10981" /db_xref="UniProtKB/Swiss-Prot:P39139" /translation="MAVKDRYMSKIKQETKPWIKRFGRLGYFAFGGVFILLGVLAFMT AAGAGRAKDSSGALQTLSRMPYGSLLLFFIGIGLIGYVIWMVLSAIKDTEGHGNSRRG LSRRIGNFFSAAVYTSIAWNALRFVFGQGDGGTSEQTWSAYVLAQPFGQWLTGLTGAG FIVFAIVQFMKGVRAAFMKEFDTSKMNKQMICITKNTGRAGNIARAIIFSAIGYFLIK TAMTADPDDTRGFDGALAELAQQPHGKLILSILALGLILYGMYAIMKGIYQHMTWEK* " gene complement(3873961..3874788) /gene="yxxB" /locus_tag="BSU_39440" /old_locus_tag="BSU39440" downshifts complement(3874760) /Source="Nicolas_upshifts" /id="D2045" /incds=0 /nref=6 /ntot=96 /MaxReadThrough="4.46865" /MaxDrop="3.48502" /score="14.6805498" /energy="-16" /TU="U3109,U3111" /idTUdmin="U3111" /TUdmin="-770" /isTUend="FALSE" promotor_-10 complement(3874813..3874831) /Source="Nicolas_upshift_promotors" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3874826) /Source="Nicolas_upshifts" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" promotor_-35 complement(3874845..3874851) /Source="Nicolas_upshift_promotors" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3874861..3875973) /gene="yxeR" /locus_tag="BSU_39450" /old_locus_tag="BSU39450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1860825, 10746760, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ethanolamine permease" /protein_id="NP_391824.1" /db_xref="EnsemblGenomes-Gn:BSU39450" /db_xref="EnsemblGenomes-Tr:CAB15981" /db_xref="GOA:P54957" /db_xref="InterPro:IPR007441" /db_xref="SubtiList:BG11894" /db_xref="UniProtKB/Swiss-Prot:P54957" /translation="MTVNDAVVFILAAFLLWGAADYCLGNRWGLGERFADGFKAMGPL ALSMIGIVSLAPVLAAILIPIVAPFYTAIGADPSSFANTILAIDMGGYALAGEMAKDP QAGLFSWVFLGTMMGPAIVFTIPVALGIIEKEDHPYFAKGILIGLCTVPIGCLIGGLC AGFDIGMIGKNLLIPSLLSAVIAFGLWRYTDRMIQLFHLFGKAVSMVAIIGLAAVSVE TMTGIVLIPGMENVETGIQTTGTIAIALAGAFPMTAFITKTFKKPLQALGKCLHLDET ATAGLVTSLAHHIPMLASLKDMTPRGKVINVAFAVSGAFVLGSHLGFVAGMKKEMAAA MIIGKLAGGVTAAAAAAWMTPAQSAKQQKRISASHS*" gene complement(3874861..3875973) /gene="yxeR" /locus_tag="BSU_39450" /old_locus_tag="BSU39450" CDS complement(3876043..3877380) /gene="yxeQ" /locus_tag="BSU_39460" /old_locus_tag="BSU39460" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative catabolic enzyme" /protein_id="NP_391825.2" /db_xref="EnsemblGenomes-Gn:BSU39460" /db_xref="EnsemblGenomes-Tr:CAB15982" /db_xref="GOA:P54956" /db_xref="InterPro:IPR005656" /db_xref="InterPro:IPR036148" /db_xref="SubtiList:BG11893" /db_xref="UniProtKB/Swiss-Prot:P54956" /translation="MSKQGLTAGLAEAVRTSQPEHSVDAIHEAKKGLLDFTAASFAGR EDKGIQKLLRLIEDEGGRPLVPVIGQGKKAAPLQSAMLNGFIAHALDFDDVHSDVRGH PSAVIVPALIASAARGHDERLLGAYVVGVEVMARLGESIGSRHYEKGWHNTGTLGAIA AACAVGYAEELTQEELEKAIGFAATQSAGMRVQFGTEMKPLHAGLAAQAGLLAVKLAQ SEFGGSRTALDGETGFFSLYGDVEKAQHTLLNDWGAPWRIVQPGLWFKIYPFCSAAHH AADAVRQLISEETISAANTERIEVIFPPGGDAALTERSPKAGEEGRFSVEYVIALALH GHGLTVEHFSSQPIPNGVQTTMGRIQRVYDNAIQPAPHAVPKGRFTIVRAYLSDGRIC EARVDCPKGAPGNELSEEDIIEKLTLTVPQEKARRIITAVEKADIKEFLAHIE*" gene complement(3876043..3877380) /gene="yxeQ" /locus_tag="BSU_39460" /old_locus_tag="BSU39460" CDS complement(3877377..3878519) /gene="sndB" /locus_tag="BSU_39470" /old_locus_tag="BSU39470" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12193636, 16513748, 16885442, 23944997, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 16513748, 16885442, 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-sulfur-metabolite deacetylase" /protein_id="NP_391826.2" /db_xref="EnsemblGenomes-Gn:BSU39470" /db_xref="EnsemblGenomes-Tr:CAB15983" /db_xref="GOA:P54955" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR033846" /db_xref="InterPro:IPR036264" /db_xref="PDB:1YSJ" /db_xref="SubtiList:BG11892" /db_xref="UniProtKB/Swiss-Prot:P54955" /translation="MADKAFHTRLINMRRDLHEHPELSFQEVETTKKIRRWLEEEQIE ILDVPQLKTGVIAEIKGREDGPVIAIRADIDALPIQEQTNLPFASKVDGTMHACGHDF HTASIIGTAMLLNQRRAELKGTVRFIFQPAEEIAAGARKVLEAGVLNGVSAIFGMHNK PDLPVGTIGVKEGPLMASVDRFEIVIKGKGGHAGIPNNSIDPIAAAGQIISGLQSVVS RNISSLQNAVVSITRVQAGTSWNVIPDQAEMEGTVRTFQKEARQAVPEHMRRVAEGIA AGYGAQAEFKWFPYLPSVQNDGTFLNAASEAAARLGYQTVHAEQSPGGEDFALYQEKI PGFFVWMGTNGTEEWHHPAFTLDEEALTVASQYFAELAVIVLETIK*" gene complement(3877377..3878519) /gene="sndB" /locus_tag="BSU_39470" /old_locus_tag="BSU39470" CDS complement(3878536..3879285) /gene="yxeO" /locus_tag="BSU_39480" /old_locus_tag="BSU39480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442, 25875741; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391827.1" /db_xref="EnsemblGenomes-Gn:BSU39480" /db_xref="EnsemblGenomes-Tr:CAB15984" /db_xref="GOA:P54954" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11891" /db_xref="UniProtKB/Swiss-Prot:P54954" /translation="MITVKNIRKAFKDLVVLDGIDLEVKRGEVVAIIGPSGSGKSTLL RCLNLLERPDQGLIEIGEAKLNAEKFTRKEAHRLRQQTAMVFQNYNLFKNKTALQNIT EALIVAQHKPRDEAKRIGMEILKQVGLEHKADSYPITMSGGQQQRIGIARALAVNPHA ILLDEPTSALDPELVTGVLQVIKSIAEKQTTMIIVTHEMAFAKEVADQVIFMADGHII EQGTPEELFDHPKNERTKRFIKQVGEPAELI*" gene complement(3878536..3879285) /gene="yxeO" /locus_tag="BSU_39480" /old_locus_tag="BSU39480" CDS complement(3879298..3879972) /gene="yxeN" /locus_tag="BSU_39490" /old_locus_tag="BSU39490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 15849754, 16513748, 16850406, 16885442; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_391828.1" /db_xref="EnsemblGenomes-Gn:BSU39490" /db_xref="EnsemblGenomes-Tr:CAB15985" /db_xref="GOA:P54953" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11890" /db_xref="UniProtKB/Swiss-Prot:P54953" /translation="MNTIDWEFMISAFPTLIQALPITLFMAIAAMIFAIIGGLILALI TKNKIPVLHQLSKLYISFFRGVPTLVQLFLIYYGLPQLFPEMSKMTALTAAIIGLSLK NAAYLAEIFRAALNSVDDGQLEACLSVGMTKFQAYRRIILPQAIRNAIPATGNTFIGL LKETSLAFTLGVMEMFAQGKMYASGNLKYFETYLAVAIVYWVLTIIYSILQDLFERAM SKPYRT*" gene complement(3879298..3879972) /gene="yxeN" /locus_tag="BSU_39490" /old_locus_tag="BSU39490" CDS complement(3879995..3880789) /gene="yxeM" /locus_tag="BSU_39500" /old_locus_tag="BSU39500" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_391829.1" /db_xref="EnsemblGenomes-Gn:BSU39500" /db_xref="EnsemblGenomes-Tr:CAB15986" /db_xref="GOA:P54952" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11889" /db_xref="UniProtKB/Swiss-Prot:P54952" /translation="MKMKKWTVLVVAALLAVLSACGNGNSSSKEDDNVLHVGATGQSY PFAYKENGKLTGFDVEVMEAVAKKIDMKLDWKLLEFSGLMGELQTGKLDTISNQVAVT DERKETYNFTKPYAYAGTQIVVKKDNTDIKSVDDLKGKTVAAVLGSNHAKNLESKDPD KKINIKTYETQEGTLKDVAYGRVDAYVNSRTVLIAQIKKTGLPLKLAGDPIVYEQVAF PFAKDDAHDKLRKKVNKALDELRKDGTLKKLSEKYFNEDITVEQKH*" gene complement(3879995..3880789) /gene="yxeM" /locus_tag="BSU_39500" /old_locus_tag="BSU39500" promotor_-35 3880361..3880370 /Source="Nicolas_upshift_promotors" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3880382 /Source="Nicolas_upshifts" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 3880383..3880398 /Source="Nicolas_upshift_promotors" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3880814..3881311) /gene="snaB" /locus_tag="BSU_39510" /old_locus_tag="BSU39510" /EC_number="2.3.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12193636, 16513748, 16885442, 23944997, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 16513748, 16885442, 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfur-containing aminoacid acetyltransferase" /protein_id="NP_391830.2" /db_xref="EnsemblGenomes-Gn:BSU39510" /db_xref="EnsemblGenomes-Tr:CAB15987" /db_xref="GOA:P54951" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11888" /db_xref="UniProtKB/Swiss-Prot:P54951" /translation="MKPRYRLAVERDAEQLLELTLRAYEPIRKLGIRFAAAHADLDLV LKNIRENACYVMEEDGRIIATITLRMPWGKQPGPYGVPHIWWFAVDPDTGKKGIGTKL LQWLEETILRDTLKVPFVSLGTADKHPWLIEMYERKGYVRSGEQDLGKGHITVYMKKQ LRHDL*" gene complement(3880814..3881311) /gene="snaB" /locus_tag="BSU_39510" /old_locus_tag="BSU39510" CDS complement(3881325..3882650) /gene="yxeK" /locus_tag="BSU_39520" /old_locus_tag="BSU39520" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8892809, 12193636, 15294834, 16513748, 16885442, 23944997; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative monooxygenase" /protein_id="NP_391831.1" /db_xref="EnsemblGenomes-Gn:BSU39520" /db_xref="EnsemblGenomes-Tr:CAB15988" /db_xref="GOA:P54950" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR016215" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG11887" /db_xref="UniProtKB/Swiss-Prot:P54950" /translation="MTSKKKQIKLGVFLAGTGHHVASWRHPDAPSDASMNLDYFKELA KTAERGKLDMLFLADSLSIDSKSHPNVLTRFEPFTLLSALAQVTSKIGLTATASTTYS EPFHIARQFASLDHLSNGRAGWNVVTSSIESTALNFSGEKHLEHHLRYQRAEEFVEIV KGLWDSWEEDAFIRNKETGEFFDKEKMHELNHKGEYFSVRGPLNVSRTPQGQPVIIQA GSSGDGKALAAKTAEVIFTAQNHLESAQEFYQSIKEQAAEFGRDPEKIAIMPGIFPII ADTEEAAQAKYKELQDLIIPSVGLQILQNYLGGIDLSAYPLDGPLPKLDAEASNAVKS RFKLVQEMAERDNMTIRELYKYVAGSRGHHIFVGTPEQLADKMQEWVDTKACDGFNIM PPLLPEGIEVFVDQVVPILQERGVFRKEYEGTTLREHFGLEKPVNRYAK*" gene complement(3881325..3882650) /gene="yxeK" /locus_tag="BSU_39520" /old_locus_tag="BSU39520" promotor_-10 complement(3882727..3882746) /Source="Nicolas_upshift_promotors" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3882731) /Source="Nicolas_upshifts" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" promotor_-35 complement(3882760..3882767) /Source="Nicolas_upshift_promotors" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3882836..3883063) /gene="yxeJ" /locus_tag="BSU_39530" /old_locus_tag="BSU39530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_391832.2" /db_xref="EnsemblGenomes-Gn:BSU39530" /db_xref="EnsemblGenomes-Tr:CAB15989" /db_xref="SubtiList:BG11886" /db_xref="UniProtKB/Swiss-Prot:P54949" /translation="MSLINSHQSADSGLNIWSQLFFYTIVTASEWIGGLQKRRKGKGN GEILYEIIGRKLSLCFIRLSFLADIEVALVE*" gene complement(3882836..3883063) /gene="yxeJ" /locus_tag="BSU_39530" /old_locus_tag="BSU39530" CDS complement(3883050..3884036) /gene="yxeI" /locus_tag="BSU_39540" /old_locus_tag="BSU39540" /EC_number="3.5.1.11" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15937167, 16511127, 18667582, 21978958" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937167, 16511127, 18667582, 21978958; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin V amidase" /protein_id="NP_391833.2" /db_xref="EnsemblGenomes-Gn:BSU39540" /db_xref="EnsemblGenomes-Tr:CAB15990" /db_xref="GOA:P54948" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR029132" /db_xref="PDB:2OQC" /db_xref="SubtiList:BG11885" /db_xref="UniProtKB/Swiss-Prot:P54948" /translation="MCTSLTLETADRKHVLARTMDFAFQLGTEVILYPRRYSWNSEAD GRAHQTQYAFIGMGRKLGNILFADGINESGLSCAALYFPGYAEYEKTIREDTVHIVPH EFVTWVLSVCQSLEDVKEKIRSLTIVEKKLDLLDTVLPLHWILSDRTGRNLTIEPRAD GLKVYDNQPGVMTNSPDFIWHVTNLQQYTGIRPKQLESKEMGGLALSAFGQGLGTVGL PGDYTPPSRFVRAVYLKEHLEPAADETKGVTAAFQILANMTIPKGAVITEEDEIHYTQ YTSVMCNETGNYYFHHYDNRQIQKVNLFHEDLDCLEPKVFSAKAEESIHELN*" gene complement(3883050..3884036) /gene="yxeI" /locus_tag="BSU_39540" /old_locus_tag="BSU39540" downshifts complement(3883054) /Source="Nicolas_upshifts" /id="D2046" /incds=0 /nref=7 /ntot=52 /MaxReadThrough="2.95669" /MaxDrop="3.32309" /score="23.0334771" /energy="-17.9" /TU="NA" /idTUdmin="U3113" /TUdmin=0 /isTUend="TRUE" promotor_-35 3883187..3883196 /Source="Nicolas_upshift_promotors" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3883210..3883229 /Source="Nicolas_upshift_promotors" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3883220..3883853 /Source="Nicolas_S_feature" /locus_tag="new_4062713_4063346" /HighExp="S6, S7, S8, S5, Paraq, G150, H2O2, G180, LBGexp, Oxctl" /AntisenseName="yxeI" /AntisenseCor="0.24221971906572701" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S1520" upshifts 3883220 /Source="Nicolas_upshifts" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" promotor_-10 complement(3884091..3884110) /Source="Nicolas_upshift_promotors" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3884102) /Source="Nicolas_upshifts" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" promotor_-35 complement(3884125..3884132) /Source="Nicolas_upshift_promotors" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3884191..3885003) /gene="hadM" /locus_tag="BSU_39550" /old_locus_tag="BSU39550" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 21575135, 23582330, 25527541, 25848029, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sugar-phosphate hydrolase (promiscuous)" /protein_id="NP_391834.1" /db_xref="EnsemblGenomes-Gn:BSU39550" /db_xref="EnsemblGenomes-Tr:CAB15991" /db_xref="GOA:P54947" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11884" /db_xref="UniProtKB/Swiss-Prot:P54947" /translation="MYKLIAIDMDGTLLNDHHEVTEEVRDALHAAKAEGVKIVLCTGR PIGGVQRYLDELNLIEEGDYVIAYNGALVQNTHTNEVVSELSLGYDDLTSLYDLSLEL KTPMHFFDSSNLYTPNRDISEFTVYESYVTQVPLHFRKIDEVPKDILIPKVMFIDKPE NLSRVITSIPKDVREKYTMVRSAPFFYEILHSEASKGNAVRQLAQLLGIEQAEVMCIG DNGNDLTMIEWAGCGVAMANAIPEVLEAANFQTRSNNEHGVAHAIHELVLAK*" gene complement(3884191..3885003) /gene="hadM" /locus_tag="BSU_39550" /old_locus_tag="BSU39550" promotor_-10 complement(3885033..3885052) /Source="Nicolas_upshift_promotors" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3885043..3885600) /gene="yxeG" /locus_tag="BSU_39560" /old_locus_tag="BSU39560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391835.1" /db_xref="EnsemblGenomes-Gn:BSU39560" /db_xref="EnsemblGenomes-Tr:CAB15992" /db_xref="GOA:P54946" /db_xref="SubtiList:BG11883" /db_xref="UniProtKB/Swiss-Prot:P54946" /translation="MRNQKAERLVAAGLVLHIIQWIFILWAFLKVKHLFSDYTIYNPN VISGSMQSLSFIQMMRAMMYSGAIVNYVLFFALVLLIYGIVLHAILIVLEMAAYVMIR RNPSSSWGFFFIAAGVKLAILNITGIPFLAAGFLLMKQKKAENGVKAERKRKPRLRIR RQGRRLNRIRRKPSLPVEYQKEKTI*" gene complement(3885043..3885600) /gene="yxeG" /locus_tag="BSU_39560" /old_locus_tag="BSU39560" upshifts complement(3885056) /Source="Nicolas_upshifts" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" promotor_-35 complement(3885067..3885074) /Source="Nicolas_upshift_promotors" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3885581..3886015) /gene="yxeF" /locus_tag="BSU_39570" /old_locus_tag="BSU39570" /function="18: Unknown function" /experiment="publication(s) with functional evidences, PMID:11160890, 22693626" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 22693626; Product type s: structure" /codon_start=1 /transl_table=11 /product="lipocalin-like lipoprotein" /protein_id="NP_391836.1" /db_xref="EnsemblGenomes-Gn:BSU39570" /db_xref="EnsemblGenomes-Tr:CAB15993" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR021664" /db_xref="PDB:2JOZ" /db_xref="SubtiList:BG11882" /db_xref="UniProtKB/Swiss-Prot:P54945" /translation="MVIPLRNKYGILFLIAVCIMVSGCQQQKEETPFYYGTWDEGRAP GPTDGVKSATVTFTEDEVVETEVMEGRGEVQLPFMAYKVISQSTDGSIEIQYLGPYYP LKSTLKRGENGTLIWEQNGQRKTMTRIESKTGREEKDEKSKS*" gene complement(3885581..3886015) /gene="yxeF" /locus_tag="BSU_39570" /old_locus_tag="BSU39570" promotor_-35 3886040..3886049 /Source="Nicolas_upshift_promotors" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3886059 /Source="Nicolas_upshifts" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" promotor_-10 3886062..3886081 /Source="Nicolas_upshift_promotors" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3886075) /Source="Nicolas_upshifts" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" S_feature complement(3886076..3886487) /Source="Nicolas_S_feature" /locus_tag="new_4065569_4065980_c" /HighExp="Salt, H2O2, Paraq, dia15, Oxctl, Diami, Cold, G150, Lbtran, LBGexp" /AntisenseName="yxeE" /AntisenseCor="-0.602938477548701" /AntisenseRegPval="-27.3" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.391, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1521" promotor_-10 complement(3886081..3886095) /Source="Nicolas_upshift_promotors" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3886104..3886108) /Source="Nicolas_upshift_promotors" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3886104..3886469 /gene="cotNE" /locus_tag="BSU_39580" /old_locus_tag="BSU39580" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 17905812, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 17905812, 19933362; Product type s: structure" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391837.1" /db_xref="EnsemblGenomes-Gn:BSU39580" /db_xref="EnsemblGenomes-Tr:CAB15994" /db_xref="SubtiList:BG11881" /db_xref="UniProtKB/Swiss-Prot:P54944" /translation="MNPYQYYSPQLPQQEPYYSHYEYNPYPQQDVYDPYQMDRQPALE RRIAALERQNEQQSRELTRLTNEDRRQNREIARIAEQVNQLSQAVERHTRRLNRLNQR LRTVENRLNIPFTAGEGGF*" gene 3886104..3886469 /gene="cotNE" /locus_tag="BSU_39580" /old_locus_tag="BSU39580" downshifts 3886483 /Source="Nicolas_upshifts" /id="D2047" /incds=0 /nref=31 /ntot=47 /MaxReadThrough="1.46494" /MaxDrop="8.36553" /score="27.2157513" /energy="-12.2" /TU="U3115" /idTUdmin="U3115" /TUdmin="-38" /isTUend="FALSE" promotor_-10 complement(3886487..3886491) /Source="Nicolas_upshift_promotors" /id="U3117" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.390609390609391" /psig="0.390609390609391" /xcortree=290 /SigmaFactorBS="cgttttaacatataagaaatgcggaaaacgaaaccCtgagat gggagaatcgtattCCGCTttttttctttgtttcgctcagaaaccgccttcccctgca g" /listShort="S1521" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3886487) /Source="Nicolas_upshifts" /id="U3117" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.390609390609391" /psig="0.390609390609391" /xcortree=290 /SigmaFactorBS="cgttttaacatataagaaatgcggaaaacgaaaccCtgagat gggagaatcgtattCCGCTttttttctttgtttcgctcagaaaccgccttcccctgca g" /listShort="S1521" /GFF_Attribute="listLong" S_feature complement(3886489..3886575) /Source="Nicolas_S_feature" /locus_tag="new_4065982_4066068_c" /HighExp="Salt, S8, H2O2, dia15, S7, Paraq, Diami, aero, Oxctl, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1522" promotor_-35 complement(3886512) /Source="Nicolas_upshift_promotors" /id="U3117" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.390609390609391" /psig="0.390609390609391" /xcortree=290 /SigmaFactorBS="cgttttaacatataagaaatgcggaaaacgaaaccCtgagat gggagaatcgtattCCGCTttttttctttgtttcgctcagaaaccgccttcccctgca g" /listShort="S1521" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3886568..3886587) /Source="Nicolas_upshift_promotors" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3886575) /Source="Nicolas_upshifts" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" promotor_-35 complement(3886601..3886608) /Source="Nicolas_upshift_promotors" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3886648..3886654 /Source="Nicolas_upshift_promotors" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3886668..3886679 /Source="Nicolas_upshift_promotors" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3886675 /Source="Nicolas_upshifts" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" CDS 3886717..3887070 /gene="yxeD" /locus_tag="BSU_39590" /old_locus_tag="BSU39590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26506528" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391838.2" /db_xref="EnsemblGenomes-Gn:BSU39590" /db_xref="EnsemblGenomes-Tr:CAB15995" /db_xref="SubtiList:BG11880" /db_xref="UniProtKB/Swiss-Prot:P54943" /translation="MHNTQHGLQQLNQCRQTAQQLIQQTQQSSQQYRQMLHQEQQNIQ MLQQILNHEQQAAHTIQQALHGHDMAIQKCQQVVNMCNQMQQELTGQSSVMNTNVSTL PFGQNTTFQQQSYQQ*" gene 3886717..3887070 /gene="yxeD" /locus_tag="BSU_39590" /old_locus_tag="BSU39590" downshifts 3887065 /Source="Nicolas_upshifts" /id="D2048" /incds=0 /nref=24 /ntot=55 /MaxReadThrough="0.20641" /MaxDrop="6.88486" /score="27.2157513" /energy="-12.2" /TU="NA" /idTUdmin="U3119" /TUdmin="-6" /isTUend="TRUE" CDS complement(3887114..3887512) /gene="yxeC" /locus_tag="BSU_39600" /old_locus_tag="BSU39600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391839.2" /db_xref="EnsemblGenomes-Gn:BSU39600" /db_xref="EnsemblGenomes-Tr:CAB15996" /db_xref="GOA:P54942" /db_xref="SubtiList:BG11879" /db_xref="UniProtKB/Swiss-Prot:P54942" /translation="MGITKRGAAWEWLHSWWMLFIFMPFAITSFFAFLFIGIKVRNRK WIMYGIIYFFIFAFGFVLPDLPGVFIVVPLWAVTIIHGFKVRPLYLIQLDVYKDHVEA RAFAEARSEAESRFHAPKQSIQDIHIRKEQ*" gene complement(3887114..3887512) /gene="yxeC" /locus_tag="BSU_39600" /old_locus_tag="BSU39600" downshifts complement(3887122) /Source="Nicolas_upshifts" /id="D2049" /incds=0 /nref=145 /ntot=243 /MaxReadThrough="1.70512" /MaxDrop="5.26494" /score="9.81431167" /energy="-12.2" /TU="NA" /idTUdmin="U3120" /TUdmin=3 /isTUend="TRUE" promotor_-10 complement(3887527..3887546) /Source="Nicolas_upshift_promotors" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3887543) /Source="Nicolas_upshifts" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" promotor_-35 complement(3887561..3887564) /Source="Nicolas_upshift_promotors" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3887600..3887607 /Source="Nicolas_upshift_promotors" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3887616..3887634) /Source="Nicolas_upshift_promotors" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 3887622..3887641 /Source="Nicolas_upshift_promotors" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3887631 /Source="Nicolas_upshifts" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" upshifts complement(3887631) /Source="Nicolas_upshifts" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3887650..3887655) /Source="Nicolas_upshift_promotors" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3887690..3888655 /gene="frxB" /locus_tag="BSU_39610" /old_locus_tag="BSU39610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12354229, 16672620, 8388528, 19254027, 23924612, 25007174; Product type t : transporter" /codon_start=1 /transl_table=11 /product="desferrioxamine-and ferrichrome-binding transporter lipoprotein (shuttle system)" /protein_id="NP_391840.2" /db_xref="EnsemblGenomes-Gn:BSU39610" /db_xref="EnsemblGenomes-Tr:CAB15997" /db_xref="GOA:P54941" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG11878" /db_xref="UniProtKB/Swiss-Prot:P54941" /translation="MKKNILLVGMLVLLLMFVSACSGTASKGSSSDSASEKTEMRTYK SPKGNVNIPAHPKRIVTDFYAGELLSVGANVVGSGSWSFDNPFLKSKLKNVKDVGDPI SVEKVMELQPDLIVVMNEENVDKLKKIAPTVVIPYNTAKNVEDTVSMFGDIAGAKDQA KSFMADFNKKAEAAKKKIAGVIDKDATFGIYENTDKGEFWVFNDNGGRGGQAVYNALG LKAPEKIEQDVIKKGEMKQLSQEVIPEYAADYMFITDYNPKGESKTLDKLENSSIWKN LDAVKHNRVFINDFDSFYPYDPISVSKQVDIITDMLIKRAEENKK*" gene 3887690..3888655 /gene="frxB" /locus_tag="BSU_39610" /old_locus_tag="BSU39610" upshifts 3888083 /Source="Nicolas_upshifts" /id="U3123" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.726273726273726" /psig="0.726273726273726" /xcortree=773 /SigmaFactorBS="cctgacttaattgttgtcatgaatgaagagaatgttgataaa ttaaagaaaatcgctccgactgttgTCATACCTTATAACACAGCgaaaaacgtagaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 3888090..3888108 /Source="Nicolas_upshift_promotors" /id="U3123" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.726273726273726" /psig="0.726273726273726" /xcortree=773 /SigmaFactorBS="cctgacttaattgttgtcatgaatgaagagaatgttgataaa ttaaagaaaatcgctccgactgttgTCATACCTTATAACACAGCgaaaaacgtagaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 3888562 /Source="Nicolas_upshifts" /id="D2050" /incds=1 /nref=55 /ntot=191 /MaxReadThrough="6.103" /MaxDrop="4.3334" /score="22.3558496" /energy="-13.4" /TU="U3121" /idTUdmin="U3123" /TUdmin=193 /isTUend="FALSE" downshifts 3888633 /Source="Nicolas_upshifts" /id="D2051" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="4.41732" /MaxDrop="3.7101" /score="22.3558496" /energy="-13.4" /TU="U3121" /idTUdmin="U3123" /TUdmin=264 /isTUend="FALSE" S_feature 3888678..3889474 /Source="Nicolas_S_feature" /locus_tag="new_4068171_4068967" /HighExp="H2O2, Paraq, Lbexp, dia0, LBGexp, G150, B36, dia15, B60, GM 25" /AntisenseName="yxeA" /AntisenseCor="0.20524492145617201" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1523" CDS complement(3888696..3889043) /gene="yxeA" /locus_tag="BSU_39620" /old_locus_tag="BSU39620" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391841.1" /db_xref="EnsemblGenomes-Gn:BSU39620" /db_xref="EnsemblGenomes-Tr:CAB15998" /db_xref="InterPro:IPR006542" /db_xref="InterPro:IPR036166" /db_xref="PDB:3NPP" /db_xref="SubtiList:BG11877" /db_xref="UniProtKB/Swiss-Prot:P54940" /translation="MKKAMAILAVLAAAAVICGLLFFHNDVTDRFNPFIHQQDVYVQI DRDGRHLSPGGTEYTLDGYNASGKKEEVTFFAGKELRKNAYLKVKAKGKYVETWEEVK FEDMPDSVQSKLK*" gene complement(3888696..3889043) /gene="yxeA" /locus_tag="BSU_39620" /old_locus_tag="BSU39620" downshifts complement(3888709) /Source="Nicolas_upshifts" /id="D2052" /incds=0 /nref=2 /ntot=78 /MaxReadThrough="1.28842" /MaxDrop="2.99568" /score="38.5550476" /energy="-11.6" /TU="NA" /idTUdmin="U3120" /TUdmin="-1584" /isTUend="FALSE" CDS complement(3889057..3890925) /gene="tpeM" /locus_tag="BSU_39630" /old_locus_tag="BSU39630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15289557, 15849754, 15870467, 16850406, 21078927, 28472044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15289557, 15849754, 15870467, 16850406, 21078927, 28472044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease); efflux of cationic peptides" /protein_id="NP_391842.2" /db_xref="EnsemblGenomes-Gn:BSU39630" /db_xref="EnsemblGenomes-Tr:CAB15999" /db_xref="GOA:P42424" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG11129" /db_xref="UniProtKB/Swiss-Prot:P42424" /translation="MTFLQFAYKNVTRNKRAYLAFFLSSAFSVLIFFTFAMFLFHPAL KEGYLNNIAKKGLTAAEWMIFVFSFLFVLYSVNAFLKSRNKEFGILLMQGITPGQLRK LITAENMIIGVMSIAAGIIGGFIFSKTFFTVGAYILEMDALPLYMPWKALGITACGFL LLFFFLSQFTILFVRSNTVIKLIKGTGKVKPEPKPSVLLSLFGIACLCGGYGMVLKGN VHGAEPFIILLLTVIGTYFFFSQSSIWILRALKKWKTFYLRGKNIIWVSDLVYRLKDN ARLFFIVSIISAVAFTATGVLAMYKSTVGAEESAYEMEYLSYSNNPKEQTHLKDIDHE LKTHGFTYTKDKIDVSYVRYQEGETVPPVYMISESDAAKYFHVKVNGLKEDEAVYFPG TYDRNFKNEAPDQLKLLNQKGELSDQKLSVKEVKKPLISLNAIIAVNDQTFDQLKSLG DKASLYGYSYDHWKDSLEISQSLQNEIYGNYIDVHSDFASKAGTYYDTVQLPSLSLFI GLFIAIVFFVAAASFLYFRLFTDLDEDRERYRSLAKIGLSEREMAQSVTIQLAILFFF PFVIAVMHTLFALRTLAVEGYSDVAGPLSLTIGGFFIFQLLFFLAVRSSYLKKMNK*" gene complement(3889057..3890925) /gene="tpeM" /locus_tag="BSU_39630" /old_locus_tag="BSU39630" CDS complement(3890900..3891673) /gene="tpeL" /locus_tag="BSU_39640" /old_locus_tag="BSU39640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15289557, 15870467, 17600057, 21078927, 28472044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15289557, 15870467, 17600057, 21078927, 28472044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein); efflux ofcationic peptides" /protein_id="NP_391843.2" /db_xref="EnsemblGenomes-Gn:BSU39640" /db_xref="EnsemblGenomes-Tr:CAB16000" /db_xref="GOA:P42423" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11128" /db_xref="UniProtKB/Swiss-Prot:P42423" /translation="MANMLEVKHINKTYKGQVSYQALKQISFSIEEGEFTAVMGPSGS GKTTLLNIISTIDRPDSGDILINGENPHRLKRTKLAHFRRKQLGFVFQDFNLLDTLTI GENIMLPLTLEKEAPSVMEEKLHGIAAKLGIENLLNKRTFEVSGGQRQRAAIARAVIH KPSLILADEPTGNLDSKATKDVMETLQSLNRDDHVTALMVTHDPVSASYCRRVIFIKD GELFNEIYRGENRQVFYEQILDVLSMLGGNANDLSSVRL*" gene complement(3890900..3891673) /gene="tpeL" /locus_tag="BSU_39640" /old_locus_tag="BSU39640" CDS complement(3891817..3892794) /gene="tpeK" /locus_tag="BSU_39650" /old_locus_tag="BSU39650" /EC_number="2.7.13.3" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15289557, 15870467, 21283517, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15289557, 15870467, 21283517, 25875741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YxdJ]" /protein_id="NP_391844.1" /db_xref="EnsemblGenomes-Gn:BSU39650" /db_xref="EnsemblGenomes-Tr:CAB16001" /db_xref="GOA:P42422" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11127" /db_xref="UniProtKB/Swiss-Prot:P42422" /translation="MKLFLRSHAVLILLFLLQGLFVFFYYWFAGLHSFSHLFYILGVQ LLILAGYLAYRWYKDRGVYHWLSSGQEGTDIPYLGSSVFCSELYEKQMELIRLQHQKL HETEAKLDARVTYMNQWVHQVKTPLSVINLIIQEEDEPVFEQIKKEVRQIEFGLETLL YSSRLDLFERDFKIEAVSLSELLQSVIQSYKRFFIQYRVYPKMNVCDDHQIYTDAKWL KFAIGQVVTNAVKYSAGKSDRLELNVFCDEDRTVLEVKDYGVGIPSQDIKRVFDPYYT GENGRRFQESTGIGLHLVKEITDKLNHTVDISSSPGEGTSVRFSFLTKM*" gene complement(3891817..3892794) /gene="tpeK" /locus_tag="BSU_39650" /old_locus_tag="BSU39650" CDS complement(3892791..3893480) /gene="tpeJ" /locus_tag="BSU_39660" /old_locus_tag="BSU39660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15289557, 15870467, 21283517, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15289557, 15870467, 21283517, 25875741; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [TpeK(YxdK)]" /protein_id="NP_391845.1" /db_xref="EnsemblGenomes-Gn:BSU39660" /db_xref="EnsemblGenomes-Tr:CAB16002" /db_xref="GOA:P42421" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11126" /db_xref="UniProtKB/Swiss-Prot:P42421" /translation="MNKIMIVEDSEDIRGLLQNYLEKYGYQTVVAADFTAVLDVFLRE KPDVVLLDINLPAYDGYYWCRQIRQHSTSPIIFISARSGEMDQVMAIENGGDDYIEKP FSYDIVLAKIKSQIRRAYGEYAAKQGEKVVEYAGVQLFVERFELRFQDEKSELSKKES KLLEVLLERGEKVTSRDRLMEKTWDTDIFIDDNTLNVYITRLRKKLRELNAPVSIEAV RGEGYQLRAQS*" gene complement(3892791..3893480) /gene="tpeJ" /locus_tag="BSU_39660" /old_locus_tag="BSU39660" promotor_-10 complement(3893507..3893526) /Source="Nicolas_upshift_promotors" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3893525) /Source="Nicolas_upshifts" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" promotor_-35 complement(3893541..3893547) /Source="Nicolas_upshift_promotors" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3893588..3894460) /gene="iolJ" /locus_tag="BSU_39670" /old_locus_tag="BSU39670" /EC_number="4.1.2.29" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9226270, 10658656, 11325924, 18310071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9226270, 10658656, 11325924, 18310071; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-deoxy-5-keto-D-gluconic acid 6-phosphate aldolase" /protein_id="NP_391846.1" /db_xref="EnsemblGenomes-Gn:BSU39670" /db_xref="EnsemblGenomes-Tr:CAB16003" /db_xref="GOA:P42420" /db_xref="InterPro:IPR000771" /db_xref="InterPro:IPR011289" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG11125" /db_xref="UniProtKB/Swiss-Prot:P42420" /translation="MAFVSMKELLEDAKREQYAIGQFNINGLQWTKAILQAAQKEQSP VIAAASDRLVDYLGGFKTIAAMVGALIEDMAITVPVVLHLDHGSSAERCRQAIDAGFS SVMIDGSHQPIDENIAMTKEVTDYAAKHGVSVEAEVGTVGGMEDGLVGGVRYADITEC ERIVKETNIDALAAALGSVHGKYQGEPNLGFKEMEAISRMTDIPLVLHGASGIPQDQI KKAITLGHAKININTECMVAWTDETRRMFQENSDLYEPRGYLTPGIEAVEETVRSKMR EFGSAGKAAKQQVG*" gene complement(3893588..3894460) /gene="iolJ" /locus_tag="BSU_39670" /old_locus_tag="BSU39670" downshifts complement(3893592) /Source="Nicolas_upshifts" /id="D2053" /incds=0 /nref=89 /ntot=172 /MaxReadThrough="3.05314" /MaxDrop="6.87265" /score="26.7325466" /energy="-8.2" /TU="NA" /idTUdmin="U3126" /TUdmin=0 /isTUend="TRUE" CDS complement(3894481..3895317) /gene="iolI" /locus_tag="BSU_39680" /old_locus_tag="BSU39680" /EC_number="5.3.99.11" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 17619021, 16461681, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 17619021, 16461681, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inosose isomerase" /protein_id="NP_391847.1" /db_xref="EnsemblGenomes-Gn:BSU39680" /db_xref="EnsemblGenomes-Tr:CAB16004" /db_xref="GOA:P42419" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="PDB:1I60" /db_xref="PDB:1I6N" /db_xref="SubtiList:BG11124" /db_xref="UniProtKB/Swiss-Prot:P42419" /translation="MKLCFNEATTLENSNLKLDLELCEKHGYDYIEIRTMDKLPEYLK DHSLDDLAEYFQTHHIKPLALNALVFFNNRDEKGHNEIITEFKGMMETCKTLGVKYVV AVPLVTEQKIVKEEIKKSSVDVLTELSDIAEPYGVKIALEFVGHPQCTVNTFEQAYEI VNTVNRDNVGLVLDSFHFHAMGSNIESLKQADGKKIFIYHIDDTEDFPIGFLTDEDRV WPGQGAIDLDAHLSALKEIGFSDVVSVELFRPEYYKLTAEEAIQTAKKTTVDVVSKYF SM*" gene complement(3894481..3895317) /gene="iolI" /locus_tag="BSU_39680" /old_locus_tag="BSU39680" S_feature complement(3895318..3895402) /Source="Nicolas_S_feature" /locus_tag="new_4074811_4074895_c" /HighExp="M40t90, M0t90, BI, Sw, BC, T5.0H, T0.30H, T4.0H, T3.30H, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.101524" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1524" CDS complement(3895403..3896272) /gene="iolH" /locus_tag="BSU_39690" /old_locus_tag="BSU39690" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9887260, 11566986, 12112707, 23874669; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar-phosphate epimerase/isomerase" /protein_id="NP_391848.1" /db_xref="EnsemblGenomes-Gn:BSU39690" /db_xref="EnsemblGenomes-Tr:CAB16005" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11123" /db_xref="UniProtKB/Swiss-Prot:P42418" /translation="MKLALDPSMYRDDLTLEEMVYKTAELGYEYIELSPREDFCPFYK YPKVDSAKIKQLKRLLRDTGVKLSSLLPLYHWAGPDEDRRQAAVRNWKRAIEIAVELE VDLMNSEFSGSKYDPLTSEEKFIKSMDELLPVFEKEGIKLNLQAHPYDFIETHKGAMD MIRALDKDWINLVYSTAHTFFYDDGKGDIETMFDEAGDRLTHVLFADTYNHKAAHGLR YIVNPPDAKVTVHQHLDIGQGEVDFDTIFRKLREMKFDGIATNAVFAWVDERADESSR FMLKKMKEELGLA*" gene complement(3895403..3896272) /gene="iolH" /locus_tag="BSU_39690" /old_locus_tag="BSU39690" CDS complement(3896292..3897326) /gene="iolG" /locus_tag="BSU_39700" /old_locus_tag="BSU39700" /EC_number="1.1.1.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:112095, 11274120, 15678175, 9226270, 16461681, 18310071, 22720735, 25482235, 28431560" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 112095, 11274120, 15678175, 9226270, 16461681, 18310071, 22720735, 25482235, 28431560; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase" /protein_id="NP_391849.2" /db_xref="EnsemblGenomes-Gn:BSU39700" /db_xref="EnsemblGenomes-Tr:CAB16006" /db_xref="GOA:P26935" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR023794" /db_xref="InterPro:IPR036291" /db_xref="PDB:3MZ0" /db_xref="PDB:3NT2" /db_xref="PDB:3NT4" /db_xref="PDB:3NT5" /db_xref="PDB:3NTO" /db_xref="PDB:3NTQ" /db_xref="PDB:3NTR" /db_xref="PDB:4L8V" /db_xref="PDB:4L9R" /db_xref="SubtiList:BG10669" /db_xref="UniProtKB/Swiss-Prot:P26935" /translation="MSLRIGVIGTGAIGKEHINRITNKLSGAEIVAVTDVNQEAAQKV VEQYQLNATVYPNDDSLLADENVDAVLVTSWGPAHESSVLKAIKAQKYVFCEKPLATT AEGCMRIVEEEIKVGKRLVQVGFMRRYDSGYVQLKEALDNHVIGEPLMIHCAHRNPTV GDNYTTDMAVVDTLVHEIDVLHWLVNDDYESVQVIYPKKSKNALPHLKDPQIVVIETK GGIVINAEIYVNCKYGYDIQCEIVGEDGIIKLPEPSSISLRKEGRFSTDILMDWQRRF VAAYDVEIQDFIDSIQKKGEVSGPTAWDGYIAAVTTDACVKAQESGQKEKVELKEKPE FYQSFTTVQN*" gene complement(3896292..3897326) /gene="iolG" /locus_tag="BSU_39700" /old_locus_tag="BSU39700" CDS complement(3897349..3898665) /gene="iolF" /locus_tag="BSU_39710" /old_locus_tag="BSU39710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11807058, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807058, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="inositol transport protein" /protein_id="NP_391850.2" /db_xref="EnsemblGenomes-Gn:BSU39710" /db_xref="EnsemblGenomes-Tr:CAB16007" /db_xref="GOA:P42417" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11122" /db_xref="UniProtKB/Swiss-Prot:P42417" /translation="MGNTNGDSAFNKRTIAAALANYIDAGSIVAGSAGLSLWVSYLKL SDTQIGLLGALSANAISAAVGALLGGFLADKVGRKAVYTNSMLVYALGICLVLFGVNF PMLLSGYIIIGLSVGADITASWTIIAENAPKKNRARHCGVAQVAWAAGAVVVLLLSVL AGDLGLLGNKIVFAHLLVIALITYILRIRLPESDAWQTKNQPEEAQAEKPAVLNKTSY FDLLKPMYLKSILFLMGVYLVWNLAAGVMGFFMPYIYQQVGGVSANMANLLQMGLFIF TGLGVALIFMPFADKYRKTVFGIAAFMAVIGWTLFLLPVEGLPILLLFIVVIGINNGA GQQANYQLWASEIFPTQYRASAQGLMFFLVRISIGIWSLFVPMIITNFGIGTMAAILL GCVTASMIIGLLFAPNTSGKSLEQIQEELYGSPQSQVKKGTESKIM*" gene complement(3897349..3898665) /gene="iolF" /locus_tag="BSU_39710" /old_locus_tag="BSU39710" CDS complement(3898680..3899573) /gene="iolE" /locus_tag="BSU_39720" /old_locus_tag="BSU39720" /EC_number="4.2.1.44" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9226270, 14993306, 22720735, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9226270, 14993306, 22720735, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inosose dehydratase" /protein_id="NP_391851.1" /db_xref="EnsemblGenomes-Gn:BSU39720" /db_xref="EnsemblGenomes-Tr:CAB16008" /db_xref="GOA:P42416" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR023952" /db_xref="InterPro:IPR030823" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11121" /db_xref="UniProtKB/Swiss-Prot:P42416" /translation="MGKNEILWGIAPIGWRNDDMPEIGAGNTLQHLLSDIVVARFQGT EVGGFFPEPAILNKELKLRNLRIAGKWFSSFILRDGLGEAAKTFTLHCEYLQQVNADV AVVSEQTYSVQSLEKNVFTEKPHFTDDEWERLCEGLNHLGEIAAQHGLKLVYHHHLGT GVQTAEEVDRLMAGTDPAHVHLLYDTGHAYISDGDYMGMLEKHIGRIKHVHFKDARLN VMEQCRLEGQSFRQSFLKGMFTVPGDGCIDFREVYQLLLKHSYSGWIVIEAEQDPDVA NPLEYALIARNYIDQQLLDLA*" gene complement(3898680..3899573) /gene="iolE" /locus_tag="BSU_39720" /old_locus_tag="BSU39720" CDS complement(3899590..3901503) /gene="iolD" /locus_tag="BSU_39730" /old_locus_tag="BSU39730" /EC_number="3.7.1.22" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase" /protein_id="NP_391852.2" /db_xref="EnsemblGenomes-Gn:BSU39730" /db_xref="EnsemblGenomes-Tr:CAB16009" /db_xref="GOA:P42415" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR023757" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR030817" /db_xref="SubtiList:BG11120" /db_xref="UniProtKB/Swiss-Prot:P42415" /translation="MGKKIRLTTAQALIKFLNQQYIHVDGKEEPFVEGIFTIFGHGNV LGIGQALEQDAGHLKVYQGKNEQGMAHAAMAYSKQMLRRKIYAVSTSVGPGAANLVAA AGTALANNIPVLLIPADTFATRQPDPVLQQMEQEYSAAITTNDALKPVSRYWDRITRP EQLMSSLLRAFEVMTDPAKAGPATICISQDVEGEAYDFDESFFVKRVHYIDRMQPSER ELQGAAELIKSSKKPVILVGGGAKYSGARDELVAISEAYNIPLVETQAGKSTVEADFA NNLGGMGITGTLAANKAARQADLIIGIGTRYTDFATSSKTAFDFDKAKFLNINVSRMQ AYKLDAFQVVADAKVTLGKLHGLLEGYESEFGTTIRELKDEWLAERERLSKVTFKREA FDPEIKNHFSQEVLNEYADALNTELPQTTALLTINETIPEDSVIICSAGSLPGDLQRL WHSNVPNTYHLEYGYSCMGYEVSGTLGLKLAHPDREVYSIVGDGSFLMLHSELITAIQ YNKKINVLLFDNSGFGCINNLQMDHGSGSYYCEFRTDDNQILNVDYAKVAEGYGAKTY RANTVEELKAALEDAKKQDVSTLIEMKVLPKTMTDGYDSWWHVGVAEVSEQESVQKAY EAKEKKLESAKQY*" gene complement(3899590..3901503) /gene="iolD" /locus_tag="BSU_39730" /old_locus_tag="BSU39730" CDS complement(3901536..3902513) /gene="iolC" /locus_tag="BSU_39740" /old_locus_tag="BSU39740" /EC_number="2.7.1.92" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735, 23874669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735, 23874669; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2-deoxy-5-keto-D-gluconic acid kinase" /protein_id="NP_391853.1" /db_xref="EnsemblGenomes-Gn:BSU39740" /db_xref="EnsemblGenomes-Tr:CAB16010" /db_xref="GOA:P42414" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR022841" /db_xref="InterPro:IPR023314" /db_xref="InterPro:IPR029056" /db_xref="InterPro:IPR030830" /db_xref="SubtiList:BG11119" /db_xref="UniProtKB/Swiss-Prot:P42414" /translation="MKYTFNEEKAFDIVAIGRACIDLNAVEYNRPMEETMTFSKYVGG SPANIAIGSAKLGLKAGFIGKIPDDQHGRFIESYMRKTGVDTTQMIVDQDGHKAGLAF TEILSPEECSILMYRDDVADLYLEPSEVSEDYIANAKMLLVSGTALAKSPSREAVLKA VQYAKKHQVKVVFELDYRPYTWQSSDETAVYYSLVAEQSDIVIGTRDEFDVMENRTGG SNEESVNHLFGHSADLVVIKHGVEGSYAYSKSGEVFRAQAYKTKVLKTFGAGDSYASA FIYGLVSGKDIETALKYGSASASIVVSKHSSSEAMPTAEEIEQLIEAQS*" gene complement(3901536..3902513) /gene="iolC" /locus_tag="BSU_39740" /old_locus_tag="BSU39740" CDS complement(3902537..3903352) /gene="iolB" /locus_tag="BSU_39750" /old_locus_tag="BSU39750" /EC_number="5.3.1.30" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-deoxy-D-glucuronic acid isomerase" /protein_id="NP_391854.2" /db_xref="EnsemblGenomes-Gn:BSU39750" /db_xref="EnsemblGenomes-Tr:CAB16011" /db_xref="GOA:P42413" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR021120" /db_xref="InterPro:IPR023770" /db_xref="InterPro:IPR024203" /db_xref="SubtiList:BG11118" /db_xref="UniProtKB/Swiss-Prot:P42413" /translation="MSYLLRKPQSHEVSNGVKLVHEVTTSNSDLTYVEFKVLDLASGS SYTEELKKQEICIVAVTGKITVTDHESTFENIGTRESVFERKPTDSVYISNDRAFEIT AVSDARVALCYSPSEKQLPTKLIKAEDNGIEHRGQFSNKRTVHNILPDSDPSANSLLV VEVYTDSGNWSSYPPHKHDQDNLPEESFLEETYYHELDPGQGFVFQRVYTDDRSIDET MTVGNENVVIVPAGYHPVGVPDGYTSYYLNVMAGPTRKWKFYNDPAHEWILER*" gene complement(3902537..3903352) /gene="iolB" /locus_tag="BSU_39750" /old_locus_tag="BSU39750" S_feature complement(3903353..3903426) /Source="Nicolas_S_feature" /locus_tag="new_4082846_4082919_c" /HighExp="M40t90, M0t90, Lbtran, BI, Mt0, T0.30H, Sw, BC, S1, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1525" CDS complement(3903427..3904890) /gene="iolA" /locus_tag="BSU_39760" /old_locus_tag="BSU39760" /EC_number="1.2.1.27" /EC_number="1.2.1.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10658656, 11566986, 16332250, 18310071, 20971862, 22720735, 26832667" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658656, 11566986, 16332250, 18310071, 20971862, 22720735, 26832667; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylmalonate-semialdehyde dehydrogenase" /protein_id="NP_391855.1" /db_xref="EnsemblGenomes-Gn:BSU39760" /db_xref="EnsemblGenomes-Tr:CAB16012" /db_xref="GOA:P42412" /db_xref="InterPro:IPR010061" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR023510" /db_xref="PDB:1T90" /db_xref="SubtiList:BG11117" /db_xref="UniProtKB/Swiss-Prot:P42412" /translation="MAEIRKLKNYINGEWVESKTDQYEDVVNPATKEVLCQVPISTKE DIDYAAQTAAEAFKTWSKVAVPRRARILFNFQQLLSQHKEELAHLITIENGKNTKEAL GEVGRGIENVEFAAGAPSLMMGDSLASIATDVEAANYRYPIGVVGGIAPFNFPMMVPC WMFPMAIALGNTFILKPSERTPLLTEKLVELFEKAGLPKGVFNVVYGAHDVVNGILEH PEIKAISFVGSKPVGEYVYKKGSENLKRVQSLTGAKNHTIVLNDANLEDTVTNIVGAA FGSAGERCMACAVVTVEEGIADEFMAKLQEKVADIKIGNGLDDGVFLGPVIREDNKKR TLSYIEKGLEEGARLVCDGRENVSDDGYFVGPTIFDNVTTEMTIWKDEIFAPVLSVIR VKNLKEAIEIANKSEFANGACLFTSNSNAIRYFRENIDAGMLGINLGVPAPMAFFPFS GWKSSFFGTLHANGKDSVDFYTRKKVVTARYPAPDFN*" gene complement(3903427..3904890) /gene="iolA" /locus_tag="BSU_39760" /old_locus_tag="BSU39760" S_feature complement(3904891..3905095) /Source="Nicolas_S_feature" /locus_tag="new_4084384_4084588_c" /HighExp="M0t90, M40t90, Lbtran, BI, Mt0, T0.30H, BC, S1, T1.0H, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1526" promotor_-35 3904894..3904901 /Source="Nicolas_upshift_promotors" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" /label="promotor_-35" promotor_-10 3904917..3904936 /Source="Nicolas_upshift_promotors" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" /label="promotor_-10" upshifts 3904924 /Source="Nicolas_upshifts" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" S_feature 3904931..3905237 /Source="Nicolas_S_feature" /locus_tag="new_4084424_4084730" /HighExp="G180, Paraq, G150, Oxctl, H2O2, G135, Diami, LBGexp, dia5, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.788" /TUlongSig="NA" /TUlongPSig="NA" /label="S1527" promotor_-10 complement(3905077..3905096) /Source="Nicolas_upshift_promotors" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3905095) /Source="Nicolas_upshifts" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" S_feature complement(3905097..3905249) /Source="Nicolas_S_feature" /locus_tag="new_4084590_4084742_c" /HighExp="M40t90, M0t90, Lbtran, Diami, Heat, dia5, C30, BI, S1, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1528" promotor_-35 complement(3905111..3905118) /Source="Nicolas_upshift_promotors" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3905197..3905204 /Source="Nicolas_upshift_promotors" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" /label="promotor_-35" promotor_-10 3905219..3905238 /Source="Nicolas_upshift_promotors" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" /label="promotor_-10" upshifts 3905239 /Source="Nicolas_upshifts" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" promotor_-10 complement(3905250..3905269) /Source="Nicolas_upshift_promotors" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /label="promotor_-10" upshifts complement(3905266) /Source="Nicolas_upshifts" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" promotor_-35 complement(3905285..3905292) /Source="Nicolas_upshift_promotors" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /label="promotor_-35" CDS 3905306..3906061 /gene="iolR" /locus_tag="BSU_39770" /old_locus_tag="BSU39770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 11807058, 18310071, 24878601, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 11807058, 18310071, 24878601, 26735940; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the iol operon (DeoR family)" /protein_id="NP_391856.1" /db_xref="EnsemblGenomes-Gn:BSU39770" /db_xref="EnsemblGenomes-Tr:CAB16013" /db_xref="GOA:P46337" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11364" /db_xref="UniProtKB/Swiss-Prot:P46337" /translation="MKLMRIQEMEEYILSHGTVSLDELCQVFNVSKNTVRRDINKLTE KGAIEKVYGGVTSIEKTALVPFENRTIQHQDEKTKIAHYASRFIEDHDLVFIDSGTTT KSILDTLDPAKNVTILTNSLDIINAASALKNINLIIIGNNYKRKTRSFVGMDDPAMLD KYNINKAFMSATGTTLTHGLTNSDLLEYEIKKRISEKAKEVYLLADHSKFGKSTLLTY APFDRLHCIVTSQPLDDEYTQYCNEHQIGIHLA*" gene 3905306..3906061 /gene="iolR" /locus_tag="BSU_39770" /old_locus_tag="BSU39770" promotor_-35 3906040..3906046 /Source="Nicolas_upshift_promotors" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3906061..3906080 /Source="Nicolas_upshift_promotors" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3906075 /Source="Nicolas_upshifts" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" CDS 3906115..3907047 /gene="iolS" /locus_tag="BSU_39780" /old_locus_tag="BSU39780" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9226270, 15019785, 22720735, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldo-keto reductase" /protein_id="NP_391857.1" /db_xref="EnsemblGenomes-Gn:BSU39780" /db_xref="EnsemblGenomes-Tr:CAB16014" /db_xref="GOA:P46336" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:1PYF" /db_xref="PDB:1PZ0" /db_xref="SubtiList:BG11363" /db_xref="UniProtKB/Swiss-Prot:P46336" /translation="MKKAKLGKSDLQVFPIGLGTNAVGGHNLYPNLNEETGKELVREA IRNGVTMLDTAYIYGIGRSEELIGEVLREFNREDVVIATKAAHRKQGNDFVFDNSPDF LKKSVDESLKRLNTDYIDLFYIHFPDEHTPKDEAVNALNEMKKAGKIRSIGVSNFSLE QLKEANKDGLVDVLQGEYNLLNREAEKTFFPYTKEHNISFIPYFPLVSGLLAGKYTED TTFPEGDLRNEQEHFKGERFKENIRKVNKLAPIAEKHNVDIPHIVLAWYLARPEIDIL IPGAKRADQLIDNIKTADVTLSQEDISFIDKLFA*" gene 3906115..3907047 /gene="iolS" /locus_tag="BSU_39780" /old_locus_tag="BSU39780" downshifts 3907049 /Source="Nicolas_upshifts" /id="D2054" /incds=0 /nref=154 /ntot=259 /MaxReadThrough="4.521" /MaxDrop="7.17874" /score="39.70215" /energy="-17.1" /TU="U3129" /idTUdmin="U3127" /TUdmin=6 /isTUend="TRUE" promotor_-35 3907126..3907133 /Source="Nicolas_upshift_promotors" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3907147..3907166 /Source="Nicolas_upshift_promotors" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3907153..3907308 /Source="Nicolas_S_feature" /locus_tag="new_4086646_4086801" /HighExp="dia5, LPhT, Diami, Etha, dia15, LBGstat, M9-stat, Lbtran, T0.30H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.835, 0.994" /TUlongSig="SigA" /TUlongPSig="0.99" /label="S1529" upshifts 3907153 /Source="Nicolas_upshifts" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" CDS 3907309..3907959 /gene="yxcE" /locus_tag="BSU_39790" /old_locus_tag="BSU39790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391858.1" /db_xref="EnsemblGenomes-Gn:BSU39790" /db_xref="EnsemblGenomes-Tr:CAB16015" /db_xref="GOA:P46335" /db_xref="SubtiList:BG11362" /db_xref="UniProtKB/Swiss-Prot:P46335" /translation="MKLKYVKALVAVTVALGVLLPSTISHAKSFSGRSSSSYSSRSSS SSYSGSYKSSPKSSYSSGSSSSSKKSKTSDDSSSSISLKKKPSEKASSSSSKKSSGTF SGATSKVTGKTYSGKTSKAYVGGRYVSVNHYYHAGFAPSGWFGYYSGFTMGMFMISMM HPWGYTYHPVGGPGYVSYGASPIAWIVDIIALIIILIIVIALIRAFKAPKTYRRRF*" gene 3907309..3907959 /gene="yxcE" /locus_tag="BSU_39790" /old_locus_tag="BSU39790" CDS 3907963..3908271 /gene="yxcD" /locus_tag="BSU_39800" /old_locus_tag="BSU39800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391859.1" /db_xref="EnsemblGenomes-Gn:BSU39800" /db_xref="EnsemblGenomes-Tr:CAB16016" /db_xref="InterPro:IPR020516" /db_xref="SubtiList:BG11361" /db_xref="UniProtKB/Swiss-Prot:P46334" /translation="MRLILNEQEIVDGICVYISNEEDIYPEDVEVKELSYNKRTGFFA EATFGLHHKQLMSDDISEGIIQFLEEYHNFNPDVTVVELQFDKKKGFSALVFVNEAEE *" gene 3907963..3908271 /gene="yxcD" /locus_tag="BSU_39800" /old_locus_tag="BSU39800" downshifts 3908273 /Source="Nicolas_upshifts" /id="D2055" /incds=0 /nref=185 /ntot=262 /MaxReadThrough="1.91541" /MaxDrop="6.4314" /score="14.1581732" /energy="-8.8" /TU="NA" /idTUdmin="U3130" /TUdmin="-2" /isTUend="TRUE" promotor_-35 3908415..3908421 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3908437..3908455 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3908447 /Source="Nicolas_upshifts" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" CDS 3908509..3909894 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391860.1" /db_xref="EnsemblGenomes-Gn:BSU39810" /db_xref="EnsemblGenomes-Tr:CAB16017" /db_xref="GOA:P46333" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11360" /db_xref="UniProtKB/Swiss-Prot:P46333" /translation="MKKDTRKYMIYFFGALGGLLYGYDTGVISGALLFINNDIPLTTL TEGLVVSMLLLGAIFGSALSGTCSDRWGRRKVVFVLSIIFIIGALACAFSQTIGMLIA SRVILGLAVGGSTALVPVYLSEMAPTKIRGTLGTMNNLMIVTGILLAYIVNYLFTPFE AWRWMVGLAAVPAVLLLIGIAFMPESPRWLVKRGSEEEARRIMNITHDPKDIEMELAE MKQGEAEKKETTLGVLKAKWIRPMLLIGVGLAIFQQAVGINTVIYYAPTIFTKAGLGT SASALGTMGIGILNVIMCITAMILIDRVGRKKLLIWGSVGITLSLAALSGVLLTLGLS ASTAWMTVVFLGVYIVFYQATWGPVVWVLMPELFPSKARGAATGFTTLVLSAANLIVS LVFPLMLSAMGIAWVFMVFSVICLLSFFFAFYMVPETKGKSLEEIEASLKKRFKKKKS TQNQVLNERTL*" gene 3908509..3909894 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" downshifts 3909880 /Source="Nicolas_upshifts" /id="D2056" /incds=0 /nref=69 /ntot=115 /MaxReadThrough="4.59405" /MaxDrop="7.32264" /score="22.9943012" /energy="-16.4" /TU="NA" /idTUdmin="U3131" /TUdmin=0 /isTUend="TRUE" S_feature 3909925..3910475 /Source="Nicolas_S_feature" /locus_tag="new_4089418_4089968" /HighExp="Etha, C30, C90, Gly, Sw, G135, Fru, HiTm, M/G, Mal" /AntisenseName="htpG" /AntisenseCor="7.4766600377621104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1530" CDS complement(3909936..3911816) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III heat-shock protein (ATP-dependent molecular chaperone HSP90)" /protein_id="NP_391861.1" /db_xref="EnsemblGenomes-Gn:BSU39820" /db_xref="EnsemblGenomes-Tr:CAB16018" /db_xref="GOA:P46208" /db_xref="InterPro:IPR001404" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR019805" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020575" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037196" /db_xref="SubtiList:BG11359" /db_xref="UniProtKB/Swiss-Prot:P46208" /translation="MAKKEFKAESKRLLDMMINSIYTQKEIFLRELISNSSDAIDKIY YKALTDDALTFDKDSYYIKVAADKDARTLTISDTGIGMTKDELEQHLGTIAKSGSLAF KKENELKDGHDIIGQFGVGFYAAFMVADVVTVISKALGSEEAYKWESAGADGYTIEPC EKDSVGTDIILKIKENTEDDSYDEFLEEYRLKAIIKKYSDFIRYPIKMDTTINKPKEG SENEFEEVQEEQTVNSMVPIWRKNKSELTDEDYEKFYAEKHYGFDKPLTHVHISVDGA VRYNAILFVPENMPFDYYSKEYEKGLELYSNGVLIMNKCADLLPDHFSFVKGMVDSED LSLNISREMLQHDRQLKLIAKNISKKIKSELQSLLKKDREKYETFYKSFGRQLKFGVY NDFGANKDQLKDLLLFYSSKEKKLVSLDEYVSRMPEEQKFIYYATGDSYDRIEKLPQT EMVADKGYEILYFTEDIDEFAIKMLASYQEKEFKSVSSGDLGIDTDEDQKQSEEEESK YKDLFEEMKNILSDKVKNVRISKRLKSHPVCLAADGEVTIEMEKILNAMPDSQNVKAE KVLEINPNHEVFQTLQDAFEQDKEKLSLYTNLLYNQALLIEGLPIQDPVEFTNNICKV MV*" gene complement(3909936..3911816) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" downshifts complement(3909942) /Source="Nicolas_upshifts" /id="D2057" /incds=0 /nref=169 /ntot=288 /MaxReadThrough="0.81611" /MaxDrop="6.49379" /score="34.0973015" /energy="-16.4" /TU="NA" /idTUdmin="U3132" /TUdmin="-8" /isTUend="TRUE" S_feature complement(3911817..3911914) /Source="Nicolas_S_feature" /locus_tag="new_4091310_4091407_c" /HighExp="Lbtran, S1, LBGtran, C90, M40t45, M9-tran, GM 150, dia0, T-2.40H, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="SigA" /TUlongPSig="0.995" /label="S1531" promotor_-10 complement(3911905..3911924) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3911914) /Source="Nicolas_upshifts" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" promotor_-35 complement(3911939..3911946) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3911984..3912235) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391862.1" /db_xref="EnsemblGenomes-Gn:BSU39830" /db_xref="EnsemblGenomes-Tr:CAB16019" /db_xref="GOA:P46332" /db_xref="SubtiList:BG11358" /db_xref="UniProtKB/Swiss-Prot:P46332" /translation="MKVQHKKELKFYCIVTIPSAFVVLTVISFLLQEITFPVTASAFL NASWHNLLFLIPFGLFFYPVHIWMKREFGRWNDTEKKRG*" gene complement(3911984..3912235) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" downshifts complement(3912002) /Source="Nicolas_upshifts" /id="D2058" /incds=0 /nref=11 /ntot=62 /MaxReadThrough="3.50049" /MaxDrop="5.56962" /score="-3.89567108" /energy="-6.7" /TU="U3133" /idTUdmin="U3133" /TUdmin="-66" /isTUend="FALSE" misc_feature complement(3912257..3912276) /Source="Nicolas_upshift_promotors" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3912266) /Source="Nicolas_upshifts" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" promotor_-35 3912299..3912305 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3912319..3912337 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3912320 /Source="Nicolas_upshifts" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" CDS 3912352..3913173 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10746760; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391863.2" /db_xref="EnsemblGenomes-Gn:BSU39840" /db_xref="EnsemblGenomes-Tr:CAB16020" /db_xref="GOA:P46331" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11357" /db_xref="UniProtKB/Swiss-Prot:P46331" /translation="MGRLENKTAVITGAATGIGQATAEVFANEGARVIIGDINKDQME ETVDAIRKNGGQAESFHLDVSDENSVKAFADQIKDACGTIDILFNNAGVDQEGGKVHE YPVDLFDRIIAVDLRGTFLCSKYLIPLMLENGGSIINTSSMSGRAADLDRSGYNAAKG GITNLTKAMAIDYARNGIRVNSISPGTIETPLIDKLAGTKEQEMGEQFREANKWITPL GRLGQPKEMATVALFLASDDSSYVTGEDITADGGIMAYTWPGKMLIEEKWKEETK*" gene 3912352..3913173 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" downshifts 3913157 /Source="Nicolas_upshifts" /id="D2059" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="2.87575" /MaxDrop="5.67438" /score="22.9485028" /energy="-10.5" /TU="U3134" /idTUdmin="U3134" /TUdmin="-221" /isTUend="FALSE" CDS complement(3913202..3914344) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11160890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391864.1" /db_xref="EnsemblGenomes-Gn:BSU39850" /db_xref="EnsemblGenomes-Tr:CAB16021" /db_xref="GOA:P46330" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG11356" /db_xref="UniProtKB/Swiss-Prot:P46330" /translation="MPESAEAQVKEALLALLKDRDIQHITMKEIAEKAKVSRGSLYLY YEDKFSIIEDVIEDMKEGLGKALFDAFSHMDTLHLNKKRQTVHPTLSFVHEHRSFFSV MMNRGHFHRFFKDVFQQDVLLAPIHVNLTPIERDIYGHYRALYTYAIILYWLNEDAAA SPEAISQKVWELVSQKRFYWLFGKAVPGEREKEKQIDRRVVRTREALQKAFLDVLAEK QDYAGITISDITRKSNIRRATFYDHYANKEELLQTMIQRSCAEIIDHLTIASSPNEFS LKEAEKALAILLSALSNMPIVHFLNREWGVPHVIPDMFKALESFYLHQQTDIHAEKKL YAHYVSAMIIGLLLYRLDEGKAHPPEVLAREFLQFLDVKKYKVVLL*" gene complement(3913202..3914344) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" downshifts complement(3913212) /Source="Nicolas_upshifts" /id="D2060" /incds=0 /nref=10 /ntot=163 /MaxReadThrough="1.63217" /MaxDrop="3.79969" /score="-0.564494299" /energy="-10.5" /TU="NA" /idTUdmin="U3135" /TUdmin=0 /isTUend="TRUE" S_feature complement(3914345..3914444) /Source="Nicolas_S_feature" /locus_tag="new_4093838_4093937_c" /HighExp="H2O2, Diami, dia15, Paraq, G180, G135, G150, dia5, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1532" promotor_-10 complement(3914432..3914451) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3914443) /Source="Nicolas_upshifts" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" promotor_-35 complement(3914465..3914472) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3914487..3915824 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" /EC_number="1.2.1.3" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391865.2" /db_xref="EnsemblGenomes-Gn:BSU39860" /db_xref="EnsemblGenomes-Tr:CAB16022" /db_xref="GOA:P46329" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11355" /db_xref="UniProtKB/Swiss-Prot:P46329" /translation="MEQQVKDDIQRVFQLQKKQQKALRASTAEQRREKLQRFLDSVIA HEEEIIEAIRKDVRKPYHEVKKAEIEGTKKAIRDNMNNLEQWMAPKEVGSSLSPDANG ILMYEPKGVTLILGPWNYPFMLTMAPLAASLAAGNSAIVKLSDFTMNTSNIAAKVIRD AFDEKEVAIFEGEVEVATELLDQPFDHIFFTGSTNVGKIVMTAAAKHLASVTLELGGK SPTIIDSEYDLMDAAKKIAVGKFVNAGQTCIAPDYLFIKKDVQDRFAGILQTVVNAGF MEDDHTPDRSKFTQIVNDRNFNRVKDLFDDAIERGAEVVFGGVFDASDRTISPTVLKN VTPDMKIMQEEIFASILPMMNYEDIDEVIDYVNDRDKPLALYVFSKNQDLIDNVLQHT TSGNAAINDVVVHFSDVNLPFGGVNTSGIGSYHGVYGFKEFSHEKGVFIQAAE*" gene 3914487..3915824 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" S_feature complement(3915229..3915829) /Source="Nicolas_S_feature" /locus_tag="new_4094722_4095322_c" /HighExp="T1.30H, T2.30H, T2.0H, T1.0H, T-2.40H, T3.0H, T3.30H, T0.0H, T-0.40H, T-3.40H" /AntisenseName="aldX" /AntisenseCor="-0.39894728806999702" /AntisenseRegPval="-11" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1533" CDS complement(3915863..3916342) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_391866.2" /db_xref="EnsemblGenomes-Gn:BSU39870" /db_xref="EnsemblGenomes-Tr:CAB16023" /db_xref="GOA:P46328" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11354" /db_xref="UniProtKB/Swiss-Prot:P46328" /translation="MNIIPTCQVPKDLVSAFFQKHWGSPQMVISSGIYNCDELDGYGM LNDDNQIVGLITYIFEEDACEIISLDSVIENKGIGTALLEKAEEACRERNIKQIKLIT TNDNIHALAFYQKRGYRLDRLFVNAVETARKMKPEIPLLADNKIPIRDELLLVKELQ* " gene complement(3915863..3916342) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" downshifts complement(3915874) /Source="Nicolas_upshifts" /id="D2061" /incds=0 /nref=1 /ntot=39 /MaxReadThrough="3.82941" /MaxDrop="2.52984" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-616" /isTUend="FALSE" CDS complement(3916422..3917414) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391867.1" /db_xref="EnsemblGenomes-Gn:BSU39880" /db_xref="EnsemblGenomes-Tr:CAB16024" /db_xref="GOA:P46327" /db_xref="InterPro:IPR003347" /db_xref="PDB:1VRB" /db_xref="SubtiList:BG11353" /db_xref="UniProtKB/Swiss-Prot:P46327" /translation="MSAVTESVLESIISPVTMSEFLEEYWPVKPLVARGEVERFTSIP GFEKVRTLENVLAIYNNPVMVVGDAVIEESEGITDRFLVSPAEALEWYEKGAALEFDF TDLFIPQVRRWIEKLKAELRLPAGTSSKAIVYAAKNGGGFKAHFDAYTNLIFQIQGEK TWKLAKNENVSNPMQHYDLSEAPYYPDDLQSYWKGDPPKEDLPDAEIVNLTPGTMLYL PRGLWHSTKSDQATLALNITFGQPAWLDLMLAALRKKLISDNRFRELAVNHQSLHESS KSELNGYLESLIQTLSENAETLTPEQIFQSQDSDFDPYQSTQLVFRQLLTSYKF*" gene complement(3916422..3917414) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" downshifts complement(3916446) /Source="Nicolas_upshifts" /id="D2062" /incds=0 /nref=5 /ntot=98 /MaxReadThrough="5.86537" /MaxDrop="5.28716" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-1188" /isTUend="FALSE" downshifts 3917404 /Source="Nicolas_upshifts" /id="D2063" /incds=0 /nref=2 /ntot=56 /MaxReadThrough="1.15059" /MaxDrop="3.74519" /score="9.93493822" /energy="-12.4" /TU="NA" /idTUdmin="U3134" /TUdmin=4026 /isTUend="FALSE" promotor_-10 complement(3917437..3917456) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3917455) /Source="Nicolas_upshifts" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" promotor_-35 complement(3917471..3917478) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3917477..3917484 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3917498..3917922 /Source="Nicolas_S_feature" /locus_tag="new_4096991_4097415" /HighExp="T2.0H, T5.0H, M9-stat, T3.0H, T1.30H, T1.0H, T3.30H, T2.30H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.998942" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1534" upshifts 3917498 /Source="Nicolas_upshifts" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" promotor_-10 3917499..3917518 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 3917504..3917916 /gene="srlX" /locus_tag="BSU_misc_RNA_86" /product="putative small RNA or mRNA leader sequence" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" gene 3917504..3917916 /gene="srlX" /locus_tag="BSU_misc_RNA_86" upshifts complement(3917524) /Source="Nicolas_upshifts" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3917534..3917548) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3917556..3917560) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3917888 /Source="Nicolas_upshifts" /id="D2064" /incds=0 /nref=2 /ntot=9 /MaxReadThrough="8.39077" /MaxDrop="5.02548" /score="9.93493822" /energy="-12.4" /TU="U3137" /idTUdmin="U3134" /TUdmin=4510 /isTUend="FALSE" CDS 3917923..3918657 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" /EC_number="2.1.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941984, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_391868.1" /db_xref="EnsemblGenomes-Gn:BSU39890" /db_xref="EnsemblGenomes-Tr:CAB16025" /db_xref="GOA:P46326" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11352" /db_xref="UniProtKB/Swiss-Prot:P46326" /translation="MITAEECRTYKEFVDLYQSYLYPLLGARLSRMYSPKNKVIIDMG TGPGYLSIQLAKRTNAHVHAVDINPAMHEIAQEEAKKSGVSSLISFDLEDVHHLSYAD QYADFIVSYSCLHHWEDVVKGLKECYRVLAPGGKIVILDTFNPQGSHLEIMRKQIKEP EYFRFVREAFEESYSFEDIHQFVQDAGIPNYSLETFHFLPEDFIESLDELEDAPLWEQ NDQSTDHEIESVTWMLTIEKEKEGAL*" gene 3917923..3918657 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" CDS 3918657..3918926 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17083466" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391869.1" /db_xref="EnsemblGenomes-Gn:BSU39900" /db_xref="EnsemblGenomes-Tr:CAB16026" /db_xref="InterPro:IPR008792" /db_xref="SubtiList:BG11351" /db_xref="UniProtKB/Swiss-Prot:P46325" /translation="MINESTVLSKNPEMPSRKYLKSIIIEPGITLNEMASDIYNHIDG KVSIHDICSKIVNEYDVDYQTCLEDCMELFELLIDHEAIKVKQGA*" gene 3918657..3918926 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" CDS 3918930..3919412 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20185509" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391870.1" /db_xref="EnsemblGenomes-Gn:BSU39910" /db_xref="EnsemblGenomes-Tr:CAB16027" /db_xref="SubtiList:BG14166" /db_xref="UniProtKB/Swiss-Prot:O34704" /translation="MEKQKVLALPDDVHELSTHRSKSIVNYIITLLAFAKKQGLTHQD IVSWIHEQYEERGYYDEWRHINSQQPVGSFVELFIKGRRLLYDKIELFETEDKYVVNT HTWYEKEPSEAFFYFEIDPEEFSAYASILAIENAKRLGIKIDIVKETDVETAYIYKHQ *" gene 3918930..3919412 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" CDS 3919433..3921676 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" /EC_number="6.3.5.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 17083466, 20185509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 17083466, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (glutamine-hydrolyzing)" /protein_id="NP_391871.2" /db_xref="EnsemblGenomes-Gn:BSU39920" /db_xref="EnsemblGenomes-Tr:CAB16028" /db_xref="GOA:P42113" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11116" /db_xref="UniProtKB/Swiss-Prot:P42113" /translation="MCGLAGIINLAAPRSQECTFHILKGMADAISYRGPDDEQYHIDS KVGFAFRRLSILDLVNGQQPFLNEDGSIVVMVNGEIYNYKELKASLHNHMFKTTSDCE VIVHLYEEKGIGFVDDIIGMFSIAIWDKNKNKVFLVRDRFGIKPLFYTELKHELIFAS EIKSLFSHPHCPRQFNWKEALSDIWLSGEAASNHKETTSFFVNIQNLDAGHYLEINLT TNERKTASYWSLQDILLRQGYRENLHPDDLIEGYRELLADSVHRCLQSDVEVGLFLSG GIDSAAVAHFAAEKQDLHTFTVLSQSTFTNEDAKYAHWLAKDLHLPNHQVLYQLGNDE LLQPESYKHLLWICETPFCGPEQLYKFHLHKYAKAIRPNLKVMLTGQGSDEFNGGYST TLSPAENPSWEGFIESVNTMEMNRLHRLQGNIFRVWEEHFGLSPINLSYLKSNDSSQA DPWQSYVLTKYRDLQMYNCWHEDRIAAANHIENRVPFLDHRLVEWVCGIPDGLRKDLL WDKSVLRKSLTNELHTSYTHRPKVPFFYGKDVRYTHKMMFHLLKKNNYQLIEEAFSHS DASSIIQVEHIHAIMTYLEDDPEFTNFEFLLRLVNMGLLSKMTKETPSVQLDITSHLE SITIKDWHSQEGDIASRLNISANKCEGQDILALNPGVTLLRPESDSEHCIYIAEEGFI QFIVSEEDVGAWLHILCDINGKDTLHTILDRHGVSLEEVAKYIQEAIEHNIILIKQKN LPEGAYR*" gene 3919433..3921676 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" CDS 3921673..3922872 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989, 15849754, 16850406, 20185509; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391872.2" /db_xref="EnsemblGenomes-Gn:BSU39930" /db_xref="EnsemblGenomes-Tr:CAB16029" /db_xref="GOA:P42112" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11115" /db_xref="UniProtKB/Swiss-Prot:P42112" /translation="MSIFYSFSALRGLAMGIFSPIWILYLISKDYDFLQIGLMGAVLE IAKLIFEVPSGVFADRYGIKISIASSFFFSILTWAFFPFIDSAAICILAMIIWALSDS LISGSFETWMSRVAGEDRFGKEMMKNTQLLITFLIIGSIASGYLYSLNIYFPFLLVMV IYLLLFIWMSVFIKVPSVSETNHGDQNQHDSIKIIKESLKIIFNKKRVLLIVIAGFFT ATAYDTISRYWQPFLSDLGFSEKSLGYIFALGGFTALVLLTLTIRFEKKIEKNPYLAL TSLDSMGMVMTFLLSRAFRPLGIPCTAFLLAIEDIHHPIVTSYLNKFFPDSYKNTLFS LNSGVGAIGEILSGVIFGIISAAFGLSAMFVVVAVFLLIPIILYTIVPKIKDNDMKVQ IEKSQQV*" gene 3921673..3922872 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" promotor_-10 complement(3922628..3922646) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3922650) /Source="Nicolas_upshifts" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3922661..3922667) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3922863 /Source="Nicolas_upshifts" /id="D2065" /incds=0 /nref=71 /ntot=174 /MaxReadThrough="3.22879" /MaxDrop="5.42242" /score="-6.94914943" /energy="-8.5" /TU="U3137" /idTUdmin="U3137" /TUdmin="-85" /isTUend="FALSE" downshifts complement(3922936) /Source="Nicolas_upshifts" /id="D2066" /incds=0 /nref=156 /ntot=227 /MaxReadThrough="3.53794" /MaxDrop="6.77896" /score="7.32872401" /energy="-16.9" /TU="U3140" /idTUdmin="U3141" /TUdmin=0 /isTUend="TRUE" CDS complement(3922936..3924168) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 15743949, 17060472, 18165306, 22720735, 26060272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane associated protein kinase with beta-propeller domain" /protein_id="NP_391873.2" /db_xref="EnsemblGenomes-Gn:BSU39940" /db_xref="EnsemblGenomes-Tr:CAB16030" /db_xref="GOA:P42111" /db_xref="InterPro:IPR002372" /db_xref="InterPro:IPR011047" /db_xref="InterPro:IPR018391" /db_xref="SubtiList:BG11114" /db_xref="UniProtKB/Swiss-Prot:P42111" /translation="MVKSFRMKALIAGAAVAAAVSAGAVSDVPAAKVLQPTAAYAAET VFSQNNGASGFLPGRYDVQAMAPAMFNWSRESRFAGNTDGTLKWQNDIRTTPQNGAGA VIDGDGTVYLHSRDGEMKAFNPDGSVKWVTGNLGKTYTQSPVLGTNGVIYLASYDKKI YFIDKETGEILTTVPLSGGPSSETVIGSDGTLYFSTLDNYVHAIKPTSKSTWTERWKL KTNGVVSSVPVLAKNGTVYVGTYNYVFYAINSGTGQVKWSRTTSNAFKGYPVIDKDGN IYAGNQDGQLYAYTSTGSLKWTFPLNGFSSSSPAIDHNGNIYIGSGSGELFSISKNGD MNWSFYTDGPVRTAPLIDAKGTVYFGSDDMKVYAADANGNELWSYQTDSNVVSSPQLA EDGTLYIGSYTKLMAFGK*" gene complement(3922936..3924168) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" promotor_-10 complement(3924200..3924219) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3924212) /Source="Nicolas_upshifts" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" promotor_-35 complement(3924233..3924238) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3924269..3924694) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15743949, 15849754, 16850406, 27902860; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391875.2" /db_xref="EnsemblGenomes-Gn:BSU39950" /db_xref="EnsemblGenomes-Tr:CAB16032" /db_xref="GOA:P42109" /db_xref="InterPro:IPR020204" /db_xref="SubtiList:BG11112" /db_xref="UniProtKB/Swiss-Prot:P42109" /translation="MSKKNSVAIMTTISAFLFCAVIVAASLSPLAGTGAAANQFNSAG MWSAVGMILVLYFIPFLVYMLGVDAMRYVMAVLCGFGLLIHLSSAGFILMFSFFSDHL LSEVIFVLGVSLAAAAVNVIWFVAAFRSGAEKTSVNTLT*" gene complement(3924269..3924694) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" promotor_-10 complement(3924722..3924741) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3924736) /Source="Nicolas_upshifts" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" promotor_-35 complement(3924754..3924760) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3924886..3924893 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3924903 /Source="Nicolas_upshifts" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" promotor_-10 3924908..3924927 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3924951..3925406 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391876.1" /db_xref="EnsemblGenomes-Gn:BSU39960" /db_xref="EnsemblGenomes-Tr:CAB16033" /db_xref="GOA:P42108" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11111" /db_xref="UniProtKB/Swiss-Prot:P42108" /translation="MEKPAGFWIRFLAYFIDGIIVSVPSYIILFIINSVFVAGAVATN PYMTEEEYLVKYMTLAFLPTMLIMIVISVLYYGLLTASKMQGTLGKKILGLKVVNEQG ERVSVGQGIGRYFAYILSGIIFYIGFIMIAFGEKKGLHDIICKTRVVYK*" gene 3924951..3925406 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" downshifts 3925344 /Source="Nicolas_upshifts" /id="D2067" /incds=1 /nref=58 /ntot=234 /MaxReadThrough="3.24719" /MaxDrop="5.4441" /score="18.1083522" /energy="-13.4" /TU="U3142" /idTUdmin="U3142" /TUdmin="-637" /isTUend="FALSE" S_feature 3925407..3926020 /Source="Nicolas_S_feature" /locus_tag="new_4104900_4105513" /HighExp="LPh, HPh, MG 60, BMM, MG t5, G180, MG 45, G150, MG-0.2, MG 10" /AntisenseName="yxaH" /AntisenseCor="0.37646026982403002" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1535" CDS complement(3925436..3926644) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein involved in response to flavonoids" /protein_id="NP_391877.2" /db_xref="EnsemblGenomes-Gn:BSU39970" /db_xref="EnsemblGenomes-Tr:CAB16034" /db_xref="GOA:P42107" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11110" /db_xref="UniProtKB/Swiss-Prot:P42107" /translation="MSSLQPTLTNERIGVLDVLRGMAIFGILFVNLAHFSYPDMYLSM LGKENFFMDKWSEADFAAADILKFFIQTKCILLFSFLFGFGMVVMMERAENKGKRFVP LYVRRLMALLLFGTIHAFLIWDGDILTEYALLGFVLLLFRKAKPKTLLIWAVSLYLLF SIPFMLTSFDQSNGQEWVQAVTQQAKQAIHVYGSGSLKDIAEQRIHDRLVYMSSNGML TYNPLNYFFASIPYFSMFLLGAAAAKSRYLHEPEKHRKGLKRLWMAGLVIGIGAQVLY SVTDKEICLLIGAPFLMFFYVTTVVYLYHKTRVRTVLQSFSAVGRMAFTNYLMQSIVC TWIFYHYGLGLYGKVYPAAGVLITIAVCAVQMVFSHLWLRVFRMGPFEWLWRSATYLS WQPIAKKTKV*" gene complement(3925436..3926644) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" downshifts complement(3925463) /Source="Nicolas_upshifts" /id="D2068" /incds=0 /nref=14 /ntot=66 /MaxReadThrough="0.30987" /MaxDrop="3.782" /score="34.1593124" /energy="-16.2" /TU="NA" /idTUdmin="U3143" /TUdmin=286 /isTUend="FALSE" S_feature complement(3926645..3926751) /Source="Nicolas_S_feature" /locus_tag="new_4106138_4106244_c" /HighExp="T-5.40H, T-4.40H, SMMPr, T-2.40H, T-3.40H, T-1.40H, Sw, T0.0H, Pyr, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1536" CDS complement(3926752..3927765) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" /EC_number="1.13.11.24" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quercetin dioxygenase" /protein_id="NP_391878.2" /db_xref="EnsemblGenomes-Gn:BSU39980" /db_xref="EnsemblGenomes-Tr:CAB16035" /db_xref="GOA:P42106" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="PDB:1Y3T" /db_xref="PDB:2H0V" /db_xref="SubtiList:BG11109" /db_xref="UniProtKB/Swiss-Prot:P42106" /translation="MKTLCTHSLPKEKMPYLLRSGEGERYLFGRQVATVMANGRSTGD LFEIVLLSGGKGDAFPLHVHKDTHEGILVLDGKLELTLDGERYLLISGDYANIPAGTP HSYRMQSHRTRLVSYTMKGNVAHLYSVIGNPYDHAEHPPYASEEVSNERFAEAAAVAD IVFLDEAKPACSAKLAELTELPDGAVPYVLESGEGDRLLTGDQLHRIVAAQKNTDGQF IVVSSEGPKGDRIVDHYHEYHTETFYCLEGQMTMWTDGQEIQLNPGDFLHVPANTVHS YRLDSHYTKMVGVLVPGLFEPFFRTLGDPYEGHIFPCEPQALRFDRILQNIEALDLKV MKP*" gene complement(3926752..3927765) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" S_feature complement(3927766..3927839) /Source="Nicolas_S_feature" /locus_tag="new_4107259_4107332_c" /HighExp="T-3.40H, T-5.40H, T-1.40H, T-2.40H, T-4.40H, T-0.40H, T0.0H, Pyr, SMMPr, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1537" promotor_-10 complement(3927824..3927843) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3927839) /Source="Nicolas_upshifts" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" promotor_-35 complement(3927856..3927863) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3927859..3928434) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17483215, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483215, 21737930; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of qdoI" /protein_id="NP_391879.2" /db_xref="EnsemblGenomes-Gn:BSU39990" /db_xref="EnsemblGenomes-Tr:CAB16036" /db_xref="GOA:P42105" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1SGM" /db_xref="SubtiList:BG11108" /db_xref="UniProtKB/Swiss-Prot:P42105" /translation="MTSRGDSREKILHTASRLFQLQGYHATGLNQIVKESGAPKGSLY HFFPNGKEELAIEAVTYTGKIVEHLIQQSMDESSDPVEAIQLFIKKTASQFDNTESIK GIPVGLLASETALISEPLRTVCMKVFKSWEAVFARKLMENGFAEEEANQLGTLINSMI EGGIMLSLTNKDKTPLLLIAEQIPVLVRKKG*" gene complement(3927859..3928434) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" downshifts complement(3927883) /Source="Nicolas_upshifts" /id="D2069" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="1.66581" /MaxDrop="2.62803" /score="-2.51956315" /energy="-8.8" /TU="NA" /idTUdmin="U3144" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3928463..3928482) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3928477) /Source="Nicolas_upshifts" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" promotor_-35 complement(3928497..3928504) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3928505..3928511 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3928526..3928544 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3928533 /Source="Nicolas_upshifts" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" CDS 3928565..3929635 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391880.2" /db_xref="EnsemblGenomes-Gn:BSU40000" /db_xref="EnsemblGenomes-Tr:CAB16037" /db_xref="GOA:O32291" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14165" /db_xref="UniProtKB/Swiss-Prot:O32291" /translation="MTIDHSVTNTEQLEQQNPAIKTKLKLKKLKDQVIVITGASSGIG LVTARMAAEKGAKVVAAARNEEALKELTDELKEKGHDAIWVKADVGKEEDVNRIAETA ISTFGRFDTWVNNAAVSTFGHAMDVTVEDMKRMFDTNFWGPVYGTRAAVKHYTGRGVP GALINVGSLFGDRGTVIQSTYASAKFALHGWTESIRMELEKEQAPVSVTLIHPGRIDT PYNEHAHSYLDKQPAHYRSMIYPPEAVAEAILFAAEHPKRDMYIGSQAKAIAMLGALF PRLTDRLMEKIMYHSQHAERPSNPREESALYDAGCGMHDRGTNKGWMRSRSYYTKATK RPIVSAAVVAGLVAWAAAKRCR*" gene 3928565..3929635 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" downshifts 3929633 /Source="Nicolas_upshifts" /id="D2070" /incds=0 /nref=7 /ntot=44 /MaxReadThrough="2.68466" /MaxDrop="3.96227" /score="-3.48213422" /energy="-11.2" /TU="NA" /idTUdmin="U3145" /TUdmin=0 /isTUend="TRUE" CDS complement(3929692..3930123) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391881.1" /db_xref="EnsemblGenomes-Gn:BSU40010" /db_xref="EnsemblGenomes-Tr:CAB16038" /db_xref="GOA:P42103" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11106" /db_xref="UniProtKB/Swiss-Prot:P42103" /translation="MQNQNPVELIEYELTTFIRRAVYLDQSEKRTGNLERSSYLLLRQ LDEFGPARVKELAESFKLDISTLSRQAAALEAKELIYRFSDPSDGRVSLFTITKLGKQ LLKADQQKRLERYEQMLKEWSTQEKEMFGELLQRMNKAFID*" gene complement(3929692..3930123) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" promotor_-35 3930153..3930160 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3930174..3930193 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3930183..3930349 /Source="Nicolas_S_feature" /locus_tag="new_4109676_4109842" /HighExp="LBGstat, Cold, Heat, Salt, Etha, H2O2, G180, LBGtran, GM 150, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1538" upshifts 3930183 /Source="Nicolas_upshifts" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" promotor_-10 complement(3930235..3930254) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3930255) /Source="Nicolas_upshifts" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" promotor_-35 complement(3930269..3930276) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3930350..3930754 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein involved in export murein hydrolases" /protein_id="YP_003097798.1" /db_xref="EnsemblGenomes-Gn:BSU40021" /db_xref="EnsemblGenomes-Tr:CAX52713" /db_xref="GOA:C0H3T7" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR036640" /db_xref="UniProtKB/Swiss-Prot:C0H3T7" /translation="MKVIRIILQVLILYVFFMIGEAIQHLFHLPVSGSIVGLVLLLIC LGLRIVPVSIIEDGAGFLLSFLPLLFIPAMTGVINYPSLISFNGLMLLITVVLSTIVT IIAAGFASQLLEKKAKKREEKEKCSKHVSRSL*" gene 3930350..3930754 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" S_feature complement(3930371..3931423) /Source="Nicolas_S_feature" /locus_tag="new_4109864_4110916_c" /HighExp="Etha, C30, H2O2, Salt, Paraq, GM 120, Diami, Oxctl, G180, Sw" /AntisenseName="yxaC" /AntisenseCor="0.145103505386703" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1539" CDS 3930724..3931416 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative murein hydrolase export regulator" /protein_id="NP_391882.3" /db_xref="EnsemblGenomes-Gn:BSU40022" /db_xref="EnsemblGenomes-Tr:CAB16039" /db_xref="GOA:P42102" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG11105" /db_xref="UniProtKB/Swiss-Prot:P42102" /translation="MQQACIAIIIILLTVAAYLAMVKLYKRFPLPFLIPVLTTTILIV AALMMFHVSYEGYMIGGKWINSLLGPAVVALAYPLYKQWHIIVKHCVPILGGVLVGLC MGMISGLIFAEAFGIDHDLLLSILPKSITTPVAIQIAAGLGGVPSMTVVFVMIAGFSG VILGPLFLKWLRIRSSLGQGIALGSASHALGTSKALEYGELAVSMSSVSMTLCAVLGS FFGPLVVWLFHI*" gene 3930724..3931416 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" CDS complement(3931456..3932487) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" /EC_number="2.-.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9298659, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exopolysaccharide pyruvyl transferase (biofilm formation)" /protein_id="NP_391883.3" /db_xref="EnsemblGenomes-Gn:BSU40030" /db_xref="EnsemblGenomes-Tr:CAB16040" /db_xref="GOA:P42101" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11104" /db_xref="UniProtKB/Swiss-Prot:P42101" /translation="MTVQEIKGKKLVKGIAPNVEPEALLNDKRKVFLFGSPSYTNIGD QAIAYAEEKFIKNHFPYYEYIEIMDYATDEGIELVKEIIREDDIVCFTGGGNLGNLYL DIEEDRRKVFSAFKDYKSISLPQSVYFEDTEEGQKEKKKTQDAYHQNTNLTIAARETQ TLDVVKETFNSNVIFTPDMVLSLDIVPRELERDGVLFILRADKEKVTDEDFISQMKQW AEKTTYTERTDTVLDTVDTIDYADREKHFMEMLDRIGSSKLVITDRLHAMIFSIITKT PCLVFGNSYGKAKHSYRDWLESLNFIEYTDKNDVEELERMIDRLLQAEPNDVDLSKDF QPLIDFFAS*" gene complement(3931456..3932487) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" downshifts complement(3931468) /Source="Nicolas_upshifts" /id="D2071" /incds=0 /nref=5 /ntot=94 /MaxReadThrough="6.52386" /MaxDrop="4.6522" /score="17.8326496" /energy="-15.3" /TU="U3149" /idTUdmin="U3150" /TUdmin=220 /isTUend="FALSE" promotor_-35 3932454..3932457 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3932470 /Source="Nicolas_upshifts" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 3932474..3932493 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3932524..3932542) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3932542) /Source="Nicolas_upshifts" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" promotor_-35 complement(3932557..3932563) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3932580..3933728) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" /EC_number="2.7.1.31" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15771780, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-glycerate kinase" /protein_id="NP_391884.2" /db_xref="EnsemblGenomes-Gn:BSU40040" /db_xref="EnsemblGenomes-Tr:CAB16041" /db_xref="GOA:P42100" /db_xref="InterPro:IPR004381" /db_xref="InterPro:IPR018193" /db_xref="InterPro:IPR036129" /db_xref="SubtiList:BG11103" /db_xref="UniProtKB/Swiss-Prot:P42100" /translation="MKIIIAPDSFKESLSALEAAEAIERGFKSVFPGADYRKLPVADG GEGTVQSLVDATNGRIIEQVVTGPLGEPVRAFFGMMGDGRTAVIEMAAASGLHLVPVD KRNPLITTTRGTGELIGAALDAGAERLIIGIGGSATNDGGAGMIQALGGRLLDNSGSE IGPGGGALSQLASIDVSGLDSRLRNVKLEVACDVDNPLTGPKGATAVFGPQKGATADM LDVLDQNVSHFADMAEKALGSTFRDTEGAGAAGGLGWSLLTYLQADLKRGIDIVLEAV DFESIVQDADLVITGEGRIDSQTVHGKTPIGVAKAAKSYDVPVIGIAGSISRDSNAVY QHGIDALFSIVPGAVPLEDAFEHAAEYMERTARDIAASIKLAKTMFLI*" gene complement(3932580..3933728) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" promotor_-10 complement(3933767..3933786) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3933778) /Source="Nicolas_upshifts" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" promotor_-35 complement(3933797..3933804) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3933850..3933857 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3933871..3933890 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3933878 /Source="Nicolas_upshifts" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" CDS 3933924..3934655 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7476858, 7642511, 8655507, 9106211, 26151451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7476858, 7642511, 8655507, 9106211, 26151451; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR-gluconate)" /protein_id="NP_391885.1" /db_xref="EnsemblGenomes-Gn:BSU40050" /db_xref="EnsemblGenomes-Tr:CAB16042" /db_xref="GOA:P10585" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10648" /db_xref="UniProtKB/Swiss-Prot:P10585" /translation="MLDSKDLLYPAKWLSKASTGVRVAYELRMRIVSGLIESGTILSE NTIAAEFSVSRSPVREALKILASEKIIRLERMGAVVIGLTEKKIAEIYDVRLLLETFV FERLVKIDIEPLVKDLSKILEMMKVSIKYEDADEFSFQDVLFHETIIRAIDHSYIQMI WNNLKPVMESFILLSMRVRLKEKYEDFTRILDNHELYIQAIKTKDRALMIQSLHQNFD DVQDKVEDLWLSQQMLAKGAEYNND*" gene 3933924..3934655 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" CDS 3934648..3936189 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" /EC_number="2.7.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1659648, 2537826, 3020045, 11468405" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1659648, 2537826, 3020045, 11468405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-gluconate kinase" /protein_id="NP_391886.1" /db_xref="EnsemblGenomes-Gn:BSU40060" /db_xref="EnsemblGenomes-Tr:CAB16043" /db_xref="GOA:P12011" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006002" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10649" /db_xref="UniProtKB/Swiss-Prot:P12011" /translation="MTSYMLGIDIGTTSTKAVLFSENGDVVQKESIGYPLYTPDISTA EQNPEEIFQAVIHTTARITKQHPEKRISFISFSSAMHSVIAIDENDKPLTPCITWADN RSEGWAHKIKEELNGHEVYKRTGTPIHPMAPLSKIAWITNERKEIASKAKKYIGIKEY IFKQLFNEYVIDYSLASATGMMNLKGLDWDEEALRIAGITPDHLSKLVPTTEIFQHCS PEIAIQMGIDPETPFVIGASDGVLSNLGVNAIKKGEIAVTIGTSGAIRTIIDKPQTDE KGRIFCYALTDKHWVIGGPVNNGGIVLRWIRDEFASSEIETATRLGIDPYDVLTKIAQ RVRPGSDGLLFHPYLAGERAPLWNPDVRGSFFGLTMSHKKEHMIRAALEGVIYNLYTV FLALTECMDGPVTRIQATGGFARSEVWRQMMSDIFESEVVVPESYESSCLGACILGLY ATGKIDSFDAVSDMIGSTYRHTPIEDSAKEYRTLMPIFINLSRLLENQYTQIADYQRG LITHK*" gene 3934648..3936189 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" CDS 3936218..3937564 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3020045, 15849754, 1659648, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3020045, 15849754, 1659648, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gluconate/proton permease" /protein_id="NP_391887.1" /db_xref="EnsemblGenomes-Gn:BSU40070" /db_xref="EnsemblGenomes-Tr:CAB16044" /db_xref="GOA:P12012" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG10650" /db_xref="UniProtKB/Swiss-Prot:P12012" /translation="MPLIIVALGILALLFLIMGLKLNTFISLLVVSFGVALALGMPFD KVVSSIEAGIGGTLGHIALIFGLGAMLGKLIADSGGAQRIAMTLVNKFGEKNIQWAVV IASFIIGIALFFEVGLVLLIPIVFAISRELKISILFLGIPMVAALSVTHGFLPPHPGP TAIAGEYGANIGEVLLYGFIVAVPTVLIAGPLFTKFAKKIVPASFAKNGNIASLGTQK TFNLEETPGFGISVFTAMLPIIIMSVATIIDLLQETIGFADNGVLAFIRLIGNASTAM IISLLVAVYTMGIKRNIPVKTVMDSCSTAISQIGMMLLIIGGGGAFKQVLINGGVGDY VADLFKGTALSPIILAWLIAAILRISLGSATVAALSTTGLVIPLLGHSDVNLALVVLA TGAGSVIASHVNDAGFWMFKEYFGLSMKETFATWTLLETIISVAGLGFILLLSLVV*" gene 3936218..3937564 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" promotor_-35 3937017..3937021 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3937037..3937056 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3937046 /Source="Nicolas_upshifts" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" CDS 3937587..3938993 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" /EC_number="1.1.1.343" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 9535092, 9931298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 9535092, 9931298; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconate dehydrogenase (NAD+-dependent)" /protein_id="NP_391888.1" /db_xref="EnsemblGenomes-Gn:BSU40080" /db_xref="EnsemblGenomes-Tr:CAB16045" /db_xref="GOA:P12013" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10651" /db_xref="UniProtKB/Swiss-Prot:P12013" /translation="MFNSIGVIGLGVMGSNIALNMANKGENVAVYNYTRDLTDQLIQK LDGQSLSPYYELEDFVQSLEKPRKIFLMVTAGKPVDSVIQSLKPLLEEGDVIMDGGNS HYEDTERRYDELKEKGIGYLGVGISGGEVGALTGPSIMPGGDRDVYEKAAPILTKIAA QVGDDPCCVYIGPKGAGHFTKMVHNGIEYADMQLIAEAYTFLRETLRLPLDEIASIFE TWNQGELKSYLIEITAEILRKKDEKTGQPLIDVILDKTGQKGTGKWTSMQAIDNGIPS TIITESLFARYLSSLKEERMAAQDVLAGPEAEEKHLDKDTWIEYVRQALYMGKVCAYA QGFAQYKMSSELYGWNLPLKDIALIFRGGCIIRADFLNVISEAFSEQPNLANLLIAPY FTDKLHAYQTGLRKVVCEGISTGISFPCLTTALSYYDGYRTGRSNANLLQAQRDYFGA HTYERTDMDGVFHTNWSE*" gene 3937587..3938993 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" downshifts 3938982 /Source="Nicolas_upshifts" /id="D2072" /incds=0 /nref=128 /ntot=228 /MaxReadThrough="3.81668" /MaxDrop="5.52642" /score="20.2280166" /energy="-10.2" /TU="NA" /idTUdmin="U3151" /TUdmin=0 /isTUend="TRUE" misc_feature 3939090..3939109 /Source="Nicolas_upshift_promotors" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3939092..3939383 /Source="Nicolas_S_feature" /locus_tag="new_4118585_4118876" /HighExp="S8, Etha, Sw, T0.30H, Cold, H2O2, B60, S5, S4, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1540" upshifts 3939092 /Source="Nicolas_upshifts" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" promotor_-35 3939356..3939363 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3939378..3939397 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3939385 /Source="Nicolas_upshifts" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" promotor_-35 3939407..3939414 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3939429..3939448 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3939432) /Source="Nicolas_upshifts" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3939435..3939449) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3939444 /Source="Nicolas_upshifts" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" promotor_-35 complement(3939457..3939461) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3939457..3940020 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" /EC_number="1.11.1.5" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932315, 14766928, 26322180" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932315, 14766928, 26322180; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (small subunit)" /protein_id="NP_391889.1" /db_xref="EnsemblGenomes-Gn:BSU40090" /db_xref="EnsemblGenomes-Tr:CAB16046" /db_xref="GOA:P80239" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017559" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11385" /db_xref="UniProtKB/Swiss-Prot:P80239" /translation="MSLIGKEVLPFEAKAFKNGEFIDVTNEDLKGQWSVFCFYPADFS FVCPTELEDLQEQYAALKELGVEVYSVSTDTHFVHKGWHDSSEKISKITYAMIGDPSQ TISRNFDVLDEETGLADRGTFIIDPDGVIQTVEINAGGIGRDASNLVNKVKAAQYVRQ NPGEVCPAKWEEGGETLTPSLDLVGKI*" gene 3939457..3940020 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" CDS 3940034..3941563 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" /EC_number="1.6.99.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932314, 14766928, 16232966, 23899494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932314, 14766928, 16232966, 23899494; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (large subunit)" /protein_id="NP_391890.1" /db_xref="EnsemblGenomes-Gn:BSU40100" /db_xref="EnsemblGenomes-Tr:CAB16047" /db_xref="GOA:P42974" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR012081" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11204" /db_xref="UniProtKB/Swiss-Prot:P42974" /translation="MVLDANIKAQLNQYMQLIENDIVLKVSAGEDDTSKDMLALVDEL ASMSSKISVEKAELNRTPSFSVNRVGEDTGVTFAGIPLGHEFTSLVLALLQVSGRPPK VDQKVIDQVKKISGEYHFESYISLTCHNCPDVVQALNMMSVLNPNITHTMIDGAAYKA EVESKNIMAVPTVYLNGESFGSGRMTLEEILAKMGSGTDASEFADKEPFDVLVVGGGP AGASAAIYTARKGIRTGVVAERFGGQVLDTMSIENFISVKATEGPKLAASLEEHVKEY DIDVMNLQRAKRLEKKDLFELELENGAVLKSKTVILSTGARWRNVNVPGEQEFKNKGV AYCPHCDGPLFEGKDVAVIGGGNSGIEAAIDLAGIVNHVTVLEFAPELKADEVLQKRL YSLPNVTVVKNAQTKEITGDQSVNGITYVDRETGEEKHVELQGVFVQIGLVPNTEWLE GTVERNRMGEIIVDKHGATSVPGLFAAGDCTDSAYNQIIISMGSGATAALGAFDYLIR N*" gene 3940034..3941563 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" downshifts complement(3941390) /Source="Nicolas_upshifts" /id="D2073" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="3.25325" /MaxDrop="3.69049" /score="1.76901559" /energy="-18" /TU="NA" /idTUdmin="U3157" /TUdmin=198 /isTUend="FALSE" downshifts 3941556 /Source="Nicolas_upshifts" /id="D2074" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="3.92009" /MaxDrop="8.88048" /score="33.1934883" /energy="-19.6" /TU="U3154" /idTUdmin="U3156" /TUdmin=0 /isTUend="TRUE" S_feature complement(3941589..3941672) /Source="Nicolas_S_feature" /locus_tag="new_4121082_4121165_c" /HighExp="G150, C30, LPhT, G135, S8, LBGstat, T0.30H, G180, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1541" downshifts complement(3941632) /Source="Nicolas_upshifts" /id="D2075" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.37922" /MaxDrop="4.44094" /score="1.76901559" /energy="-18" /TU="U3157" /idTUdmin="U3157" /TUdmin="-44" /isTUend="FALSE" CDS complement(3941673..3943112) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8125345, 14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8125345, 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-6-phospho-beta-glucosidase" /protein_id="NP_391891.1" /db_xref="EnsemblGenomes-Gn:BSU40110" /db_xref="EnsemblGenomes-Tr:CAB16048" /db_xref="GOA:P42973" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11203" /db_xref="UniProtKB/Swiss-Prot:P42973" /translation="MGNMPKDFLWGGALAAHQFEGGWNQGGKGPSVVDVMTAGAHGVP RKITDTIEENEFYPNHEAIDFYHRYKEDIALFAEMGLKCLRTSIGWSRIFPKGDEAEP NEAGLQFYDDVFDELLKHGIEPVITLSHFEMPLHLAREYGGFRNRKVVDFFVNFAEAC FTRYKDKVKYWMTFNEINNQMDVNNPLFLWTNSGVVVGENENAKEVMYQTAHHELVAS ALAVAKGKDINPEFQIGAMVSHVPIYPFSSNPEDVMLAEEEMRQRYFFPDVQVRGYYP SYALKEFEREGYNITFEDGDDEILRNGTVDYLGFSYYMSTTVKSDVKNDNTGDIVNGG LPNGVENPYITSSDWGWAIDPTGLRYTLNRFYDRYQIPLFIVENGFGAVDTLEEDGKV HDPERIQYLKSHIEALKKAVTYDGVDLIGYTPWGIIDIVSFTTGEMKKRYGMIYVDRD NEGNGSMKRYKKDSFEWYKNVIQTNGEEL*" gene complement(3941673..3943112) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" CDS complement(3943126..3943356) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" /EC_number="2.7.1.-" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867744, 28731580" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867744, 28731580; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucose phosphotransferase system enzyme IIA component" /protein_id="NP_391892.1" /db_xref="EnsemblGenomes-Gn:BSU40120" /db_xref="EnsemblGenomes-Tr:CAB16049" /db_xref="GOA:O32292" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG14172" /db_xref="UniProtKB/Swiss-Prot:O32292" /translation="MVTPTKHAIGLRSASGVELLAHIGLDTVTFDGTPFSLKVKEGDT VKKGEVLVEFDKAFIEDIEESALHQKIFTVVS*" gene complement(3943126..3943356) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" S_feature complement(3943357..3943568) /Source="Nicolas_S_feature" /locus_tag="new_4122850_4123061_c" /HighExp="G150, LPhT, T0.30H, Diami, G135, LBGstat, G180, Oxctl, Lbexp, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1542" promotor_-10 complement(3943565..3943584) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3943570) /Source="Nicolas_upshifts" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" promotor_-35 complement(3943599..3943606) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3943632..3943639 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3943650..3943669 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3943665 /Source="Nicolas_upshifts" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" CDS 3943700..3944410 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_391893.1" /db_xref="EnsemblGenomes-Gn:BSU40130" /db_xref="EnsemblGenomes-Tr:CAB16050" /db_xref="GOA:Q45591" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3BWG" /db_xref="SubtiList:BG11484" /db_xref="UniProtKB/Swiss-Prot:Q45591" /translation="MLKYQQIATEIETYIEEHQLQQGDKLPVLETLMAQFEVSKSTIT KSLELLEQKGAIFQVRGSGIFVRKHKRKGYISLLSNQGFKKDLEDFNVTSKVIELDVR KPTPEAAENLNIGMDEDIYYVKRVRYINGQTLCYEESYYTKSIVTYLNNEIVSHSIFH YIREGLGLKIGFSDLFLHVGQLNEEEAEYLGLEAGLPKLYIESIFHLTNGQPFDYSKI SYNYEQSQFVVQANSFLL*" gene 3943700..3944410 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" CDS 3944438..3944596 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097799.1" /db_xref="EnsemblGenomes-Gn:BSU40139" /db_xref="EnsemblGenomes-Tr:CAX52714" /db_xref="GOA:C0H3T8" /db_xref="UniProtKB/Swiss-Prot:C0H3T8" /translation="MYKIIIPAILAIFALWILLQISLEMSIVKNPMNYFIVFIIFFLF VKMVKEKQ*" gene 3944438..3944596 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" downshifts 3944673 /Source="Nicolas_upshifts" /id="D2076" /incds=0 /nref=16 /ntot=177 /MaxReadThrough="0.96913" /MaxDrop="4.2349" /score="-9.95345673" /energy="-14.7" /TU="NA" /idTUdmin="U3158" /TUdmin="-7" /isTUend="TRUE" CDS complement(3944727..3945449) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" /function="16.1: Circulate" /function="16.3: Control" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="permease for export of regulatory peptide LiaD*" /protein_id="NP_391894.1" /db_xref="EnsemblGenomes-Gn:BSU40140" /db_xref="EnsemblGenomes-Tr:CAB16051" /db_xref="GOA:Q45592" /db_xref="SubtiList:BG11483" /db_xref="UniProtKB/Swiss-Prot:Q45592" /translation="MKLEFKKSISNKVIIILGAMFVFLFLLGYFLLVGIDKVSNVTPE MFFFSSYTVATQFGLMLFSFVIAFFINREYSNKNILFYKLIGENIYTFFYKKIAVLFL ECFAFITLGLLIISLMYHDFSHFALLLFLFSAVILQYILIIGTISVLCPNILISIGVS IVYWMTSVILVAISNKTFGFIAPFEAGNTMYPRIERVLQSDNMTLGSNDVLFIILYLV SIIIINAIVLRFSKTRWIKMGL*" gene complement(3944727..3945449) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" downshifts complement(3944739) /Source="Nicolas_upshifts" /id="D2077" /incds=0 /nref=225 /ntot=267 /MaxReadThrough="2.70741" /MaxDrop="6.21099" /score="7.49162587" /energy="-10.5" /TU="NA" /idTUdmin="U3160" /TUdmin="-5" /isTUend="TRUE" promotor_-35 3945350..3945353 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3945369..3945373 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3945384 /Source="Nicolas_upshifts" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3945470..3946099) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter for regulatory peptide LiaD* (ATP-binding protein)" /protein_id="NP_391895.1" /db_xref="EnsemblGenomes-Gn:BSU40150" /db_xref="EnsemblGenomes-Tr:CAB16052" /db_xref="GOA:Q45593" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11482" /db_xref="UniProtKB/Swiss-Prot:Q45593" /translation="MNIANYTLKVKGKTLLQDTDLHFSSGKINHVVGKNGVGKSQLAK DFLLNNSKRIGRDIRQNVSLISSSSNIPNDVSKDFLLHFLSKKFDAKMIDKIAYLLNL DNIDGKVLIKNLSDGQKQKLKLLSFLLEDKNIIVLDEITNSLDKKTVIEIHGFLNKYI QENPEKIIINITHDLSDLKAIEGDYYIFNHQEIQQYHSVDKLIEVYINE*" gene complement(3945470..3946099) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" S_feature complement(3946100..3946248) /Source="Nicolas_S_feature" /locus_tag="new_4125593_4125741_c" /HighExp="T-0.40H, LoTm, T-2.40H, T0.0H, M9-tran, SMMPr, T-1.40H, GM 150, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1543" CDS complement(3946249..3947007) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease acting on modified factor LiaD" /protein_id="NP_391896.2" /db_xref="EnsemblGenomes-Gn:BSU40160" /db_xref="EnsemblGenomes-Tr:CAB16053" /db_xref="GOA:Q45594" /db_xref="SubtiList:BG11481" /db_xref="UniProtKB/Swiss-Prot:Q45594" /translation="MKILKYEDEKYEVLVQNNVFIKDKKSGEYYKNSLNSLSDKQLLR FKMYKEKVSPKFFYLFLSFTALMFILNYIHLIKLQNGLSSVFYGWKMWIIIVIYFIMN IVLHELGHIYSLKFFGKNFDKVGFKLNFYVFPAFYVQLNETYMLSRNEKIIVHLFGLF INYLLINTLELINQFTFSSEALTMAFMLFSSTLLWNLIPILNSDGYKILLAFLSLDEY SRFKTNHWLVLTIQIIGIGLAVNSVVHWILYIVN*" gene complement(3946249..3947007) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" promotor_-10 complement(3946697..3946716) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3946713) /Source="Nicolas_upshifts" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" promotor_-35 complement(3946729..3946736) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3946988..3947947) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" /EC_number="5.1.1.-" /experiment="publication(s) with functional evidences, PMID:17921301, 18307109, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17921301, 18307109, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="AdoMet radical amino acid epimerase modifying factor LiaD" /protein_id="NP_391897.1" /db_xref="EnsemblGenomes-Gn:BSU40170" /db_xref="EnsemblGenomes-Tr:CAB16054" /db_xref="GOA:Q45595" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR023904" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG11480" /db_xref="UniProtKB/Swiss-Prot:Q45595" /translation="MYNKTVSINLDSRCNASCDHCCFSSSPTSTTRMEKEYIRELVTE FAKNKTIQVISFTGGEVFLDYKFLKELMEIIKPYEKQITLISNGFWGLSKKKVQEYFH DMNSLNVIALTISYDEYHAPFVKSSSIKNILEHSRKYPDIDISLNMAVTKDKMSNHIL EELGDSILGVKITKFPMISVGAAKTRIKQENIHKFYSLEDEDSLHCPGYDIVYHHDGE IYPCCSPAIFETKITLREEYNQSFERTVEKLNSNLLLFILRKEGFKWFLNILKENNKI EEFDIPYEFSSICGVCGSLFNSAEKINYFYPYMEKYYNENFKV*" gene complement(3946988..3947947) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" downshifts 3947936 /Source="Nicolas_upshifts" /id="D2078" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.40583" /MaxDrop="2.5017" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-220" /isTUend="FALSE" misc_feature 3947983..3947986 /Source="Nicolas_upshift_promotors" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3947991 /Source="Nicolas_upshifts" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3948005..3948154) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 17921301, 28644475; Product type r: regulator" /codon_start=1 /transl_table=11 /product="precursor of exported modified peptide (epipeptide) controlling LiaRS activity" /protein_id="NP_391898.1" /db_xref="EnsemblGenomes-Gn:BSU40180" /db_xref="EnsemblGenomes-Tr:CAB16055" /db_xref="InterPro:IPR023898" /db_xref="SubtiList:BG11479" /db_xref="UniProtKB/Swiss-Prot:Q45596" /translation="MKKEITNNETVKNLEFKGLLDESQKLAKVNDLWYFVKSKENRWI LGSGH*" gene complement(3948005..3948154) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" downshifts complement(3948012) /Source="Nicolas_upshifts" /id="D2079" /incds=0 /nref=99 /ntot=172 /MaxReadThrough="7.62324" /MaxDrop="6.01674" /score="7.49162587" /energy="-10.5" /TU="U3163" /idTUdmin="U3167" /TUdmin=2794 /isTUend="FALSE" misc_feature 3948063..3948080 /Source="Nicolas_upshift_promotors" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3948068 /Source="Nicolas_upshifts" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 3948149 /Source="Nicolas_upshifts" /id="D2080" /incds=0 /nref=99 /ntot=170 /MaxReadThrough="2.55247" /MaxDrop="5.95806" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-7" /isTUend="TRUE" promotor_-10 complement(3948175..3948194) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3948196) /Source="Nicolas_upshifts" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" promotor_-35 complement(3948209..3948216) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3948489..3948496 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3948511..3948530 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3948515 /Source="Nicolas_upshifts" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" CDS 3948626..3950551 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" /EC_number="3.1.3.11" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:221467, 9696785, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 221467, 9696785, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphatase" /protein_id="NP_391899.2" /db_xref="EnsemblGenomes-Gn:BSU40190" /db_xref="EnsemblGenomes-Tr:CAB16056" /db_xref="GOA:Q45597" /db_xref="InterPro:IPR009164" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11478" /db_xref="UniProtKB/Swiss-Prot:Q45597" /translation="MESKYLDLLAQKYDCEEKVVTEIINLKAILNLPKGTEHFVSDLH GEYQAFQHVLRNGSGRVKEKIRDIFSGVIYDREIDELAALVYYPEDKLKLIKHDFDAK EALNEWYKETIHRMIKLVSYCSSKYTRSKLRKALPAQFAYITEELLYKTEQAGNKEQY YSEIIDQIIELGQADKLITGLAYSVQRLVVDHLHVVGDIYDRGPQPDRIMEELINYHS VDIQWGNHDVLWIGAYSGSKVCLANIIRICARYDNLDIIEDVYGINLRPLLNLAEKYY DDNPAFRPKADENRPEDEIKQITKIHQAIAMIQFKLESPIIKRRPNFNMEERLLLEKI DYDKNEITLNGKTYQLENTCFATINPEQPDQLLEEEAEVIDKLLFSVQHSEKLGRHMN FMMKKGSLYLKYNGNLLIHGCIPVDENGNMETMMIEDKPYAGRELLDVFERFLREAFA HPEETDDLATDMAWYLWTGEYSSLFGKRAMTTFERYFIKEKETHKEKKNPYYYLREDE ATCRNILAEFGLNPDHGHIINGHTPVKEIEGEDPIKANGKMIVIDGGFSKAYQSTTGI AGYTLLYNSYGMQLVAHKHFNSKAEVLSTGTDVLTVKRLVDKELERKKVKETNVGEEL LQEVAILESLREYRYMK*" gene 3948626..3950551 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" S_feature 3950552..3951916 /Source="Nicolas_S_feature" /locus_tag="new_4130045_4131409" /HighExp="Lbstat, dia5, C30, Gly, Etha, dia15, C90, Fru, G135, Mal" /AntisenseName="yydD" /AntisenseCor="0.44422072328838003" /AntisenseRegPval="-13.7" /CDS_PredictionProba="0.22050400000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1544" S_feature complement(3950764..3951084) /Source="Nicolas_S_feature" /locus_tag="new_4130257_4130577_c" /HighExp="Cold, C30, M/G, S8, Fru, nit, Glu, BMM, Heat, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1545" CDS complement(3951085..3952845) /gene="yydD" /locus_tag="BSU_40200" /old_locus_tag="BSU40200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative DNA wielding protein" /protein_id="NP_391900.1" /db_xref="EnsemblGenomes-Gn:BSU40200" /db_xref="EnsemblGenomes-Tr:CAB16057" /db_xref="InterPro:IPR018760" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11477" /db_xref="UniProtKB/Swiss-Prot:Q45598" /translation="MIVMIIKNLFVCNSQEILKEYKFNAVGVNIILGEKREDHEETNG VGKSTMIECISFLLGKTISNFYTTNEILLNKNVFIVLNVEIDGNQVFLARSFNSPKHG YTLHDTSLTFNLEEWKKVSISVYKKFIEKEILKGEKEDITFAALREYIIRDEKTGFND IVLPNRGGLKQYKLLNYLFTLPTHTEKNIKVFRDKIEKLNSEIKLIESMNINIGDLKV KEDELINEIEDYNRVIYQTKTANKYNNDTNRYSEIKSELNKIQNEIFENEHICKQYQR NIDDLNKKVTKIKELENIEKFYEDIVGFFPEEVKQNYNKVQEFYNFMVESRGSYFKDK IVKIQADLKKLNIKKQGLTEQLESSARILKSNNFIEDISIVMEEQRRKEIELAEVRLR ISDYDKKNHIFDKINELQHEILRVNSMYYDEFQSYSAIVSELKKLFNNLMDVTYNQHG FLDFEYDNRISNAKQSTTGRIKISCSIPDERSHGRLHMKINIFDLTWFLYRCINKCSL NILIHDGSYSNPDPHVKGTLLKHINSSLLENRIGQYFVTINKNELLLDDLQELESKGM IVAKLDRNNEDKNRFFGFRF*" gene complement(3951085..3952845) /gene="yydD" /locus_tag="BSU_40200" /old_locus_tag="BSU40200" downshifts complement(3951128) /Source="Nicolas_upshifts" /id="D2081" /incds=0 /nref=11 /ntot=199 /MaxReadThrough="4.99391" /MaxDrop="4.47843" /score="7.49162587" /energy="-10.5" /TU="U3167" /idTUdmin="U3167" /TUdmin="-322" /isTUend="FALSE" misc_feature 3951913..3951914 /Source="Nicolas_upshift_promotors" /id="U3165" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.67032967032967" /psig="0.255744255744256" /xcortree=83 /SigmaFactorBS="aactccctctactttctaccatgaaattatagaactcttgga ctttattataattCTgttttacttcctctggaaaaaaacctacaatatcttcatagaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3951918 /Source="Nicolas_upshifts" /id="U3165" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.67032967032967" /psig="0.255744255744256" /xcortree=83 /SigmaFactorBS="aactccctctactttctaccatgaaattatagaactcttgga ctttattataattCTgttttacttcctctggaaaaaaacctacaatatcttcatagaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3952845..3953243) /gene="yydC" /locus_tag="BSU_40210" /old_locus_tag="BSU40210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391901.1" /db_xref="EnsemblGenomes-Gn:BSU40210" /db_xref="EnsemblGenomes-Tr:CAB16058" /db_xref="SubtiList:BG11476" /db_xref="UniProtKB/Swiss-Prot:Q45599" /translation="MIDLKIETAENILKYSYVLLENEFKNIQIGNDLIPLVNNSPLKK EKAERPEMNHFLLTKYNAVEENILYSSKILYELLEKEKHIDQLFLDYAKSQGIIINLN IERILYLSLTFLYSLGKVSFNQNMISRTES*" gene complement(3952845..3953243) /gene="yydC" /locus_tag="BSU_40210" /old_locus_tag="BSU40210" CDS complement(3953236..3954681) /gene="yydB" /locus_tag="BSU_40220" /old_locus_tag="BSU40220" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphohydrolase" /protein_id="NP_391902.1" /db_xref="EnsemblGenomes-Gn:BSU40220" /db_xref="EnsemblGenomes-Tr:CAB16059" /db_xref="GOA:Q45600" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11475" /db_xref="UniProtKB/Swiss-Prot:Q45600" /translation="MKVRFLQISDLHFQFQNYDTIVMRDKLLDFIEVLRRESDFDFLL LTGDIAHKGDVYNEDVKEYLNGIIKSMGLSKNNVHLVPGNHDISRDMTRTLLIDSIMK SPNPSEMLDKLDQKATNILVEGQRKFFDFYEDFMGVKYPEEDLHFLYQSEKYNVLSIN TCLLSDKKGEEGTLLTAQMKLYKAIRKMNKEKNKGKVLNIAIGHHTLGCIESSERESI KAHFDDYFIDLYLAGHVHDSSFNITANTNENPFLELVSGAIIKDEYATPEFISVDVNL DNGETEVTYYIWNTEYKYWSKNNQGGRRLQEGKLNYKINRLESLIEKEIEDNDDKIDE DEFKSFIIDFHEYRESYKTFTSNFDNQIGLDKKFYDMKSGETFKRKFDSYSEYFGVIN HIMDSTSYVSADKKELIAETIVDKYLEFHNQYNNGDEIFVKIVNEIYLECHSVLPYSK ALTKKYIKILTCWCIYECEIFNDNKRSVKND*" gene complement(3953236..3954681) /gene="yydB" /locus_tag="BSU_40220" /old_locus_tag="BSU40220" promotor_-35 3953931..3953938 /Source="Nicolas_upshift_promotors" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3953950..3953969 /Source="Nicolas_upshift_promotors" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3953960..3955009 /Source="Nicolas_S_feature" /locus_tag="new_4133453_4134502" /HighExp="C30, Salt, Gly, S8, Etha, LPhT, T0.30H, Heat, C90, M9-stat" /AntisenseName="yydB" /AntisenseCor="0.36202116146901597" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.431" /TUlongSig="NA" /TUlongPSig="NA" /label="S1546" upshifts 3953960 /Source="Nicolas_upshifts" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" S_feature complement(3954682..3954942) /Source="Nicolas_S_feature" /locus_tag="new_4134175_4134435_c" /HighExp="Cold, M0t90, Lbtran, M40t90, Lbstat, T0.30H, MG 150, M40t45, Gly, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1547" CDS complement(3954943..3955422) /gene="rlmH" /locus_tag="BSU_40230" /old_locus_tag="BSU40230" /EC_number="2.1.1.177" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18755835, 20817755, 22411911, 22720735, 28428565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA (pseudouridine1915-N3)-methyltransferase" /protein_id="NP_391903.1" /db_xref="EnsemblGenomes-Gn:BSU40230" /db_xref="EnsemblGenomes-Tr:CAB16060" /db_xref="GOA:Q45601" /db_xref="InterPro:IPR003742" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="PDB:1TO0" /db_xref="SubtiList:BG11474" /db_xref="UniProtKB/Swiss-Prot:Q45601" /translation="MNINIVTIGKLKEKYLKQGIEEYTKRLSAYAKIDIIELPDEKAP ENLSDQDMKIIKDKEGDRILSKISPDAHVIALAIEGKMKTSEELADTIDKLATYGKSK VTFVIGGSLGLSDTVMKRADEKLSFSKMTFPHQLMRLILVEQIYRAFRINRGEPYHK* " gene complement(3954943..3955422) /gene="rlmH" /locus_tag="BSU_40230" /old_locus_tag="BSU40230" S_feature complement(3955423..3955502) /Source="Nicolas_S_feature" /locus_tag="new_4134916_4134995_c" /HighExp="dia5, LBGtran, T0.30H, Diami, Cold, M0t90, dia0, M0t45, M40t45, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1548" CDS complement(3955503..3955673) /gene="yyzF" /locus_tag="BSU_40239" /old_locus_tag="BSU40239" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097800.1" /db_xref="EnsemblGenomes-Gn:BSU40239" /db_xref="EnsemblGenomes-Tr:CAX52715" /db_xref="InterPro:IPR025626" /db_xref="UniProtKB/Swiss-Prot:C0H3T9" /translation="MKQAYYSCEEHIETVLDMYIDDHELPPEIRKIEHTNSLSTACEL CGDPAVYIVGNE*" gene complement(3955503..3955673) /gene="yyzF" /locus_tag="BSU_40239" /old_locus_tag="BSU40239" promotor_-10 complement(3955714..3955733) /Source="Nicolas_upshift_promotors" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3955730) /Source="Nicolas_upshifts" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" promotor_-35 complement(3955747..3955752) /Source="Nicolas_upshift_promotors" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3955796..3955803 /Source="Nicolas_upshift_promotors" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3955816..3955835 /Source="Nicolas_upshift_promotors" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3955833 /Source="Nicolas_upshifts" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" CDS 3955858..3956271 /gene="yycS" /locus_tag="BSU_40240" /old_locus_tag="BSU40240" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21911367; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391904.1" /db_xref="EnsemblGenomes-Gn:BSU40240" /db_xref="EnsemblGenomes-Tr:CAB16061" /db_xref="SubtiList:BG11472" /db_xref="UniProtKB/Swiss-Prot:Q45603" /translation="MRFRWVWLFVIMLLLAECQPSYWVLEKDRIGEGSPDLEIYANYL QMHDDVKGYQVFTISEGKKMVVVSLGSSEKDKKLEVSDVKFSSKETIVTVERKPAPTA NEKNPFILIGLDKIEGDLIVQDETGDRFEETDYQQ*" gene 3955858..3956271 /gene="yycS" /locus_tag="BSU_40240" /old_locus_tag="BSU40240" downshifts 3956251 /Source="Nicolas_upshifts" /id="D2082" /incds=0 /nref=17 /ntot=131 /MaxReadThrough="1.50241" /MaxDrop="5.73792" /score="16.0382598" /energy="-10.8" /TU="NA" /idTUdmin="U3168" /TUdmin=0 /isTUend="TRUE" CDS complement(3956305..3957531) /gene="yycR" /locus_tag="BSU_40250" /old_locus_tag="BSU40250" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18820069; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase" /protein_id="NP_391905.1" /db_xref="EnsemblGenomes-Gn:BSU40250" /db_xref="EnsemblGenomes-Tr:CAB16062" /db_xref="GOA:Q45604" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR014184" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11471" /db_xref="UniProtKB/Swiss-Prot:Q45604" /translation="MGGMALTGNKAVVYKGKGTVAVEDIGYPELILRDGPGVPKANVN RKCEHGVILKVITTNICGSDQHMVRGRTTAPEGLVLGHEITGEVIETGRDVEFIKKGD IVSVPFNIACGRCVMCKTQKTHVCLNVNPDRPGSAYGYVDMGGWVGGQSEYVMVPYAD FQLLVFPDKEQALEKILDLTMLSDIFPTGFHGAYTAGVQTGSTVYIAGAGPVGLAAAH SAQLLGASTVIVGDLNEDRLAQARSFGCETVNVQKHDRLGEQIEQILGEPTVDAAVDC VGFEASGHGNQGEAPAAVLNSIMDVTQVGGSLGIPGLYVTEDPGAKDADAKTGSLKIR FGLGWAKAHTFVTGQTPAMTYNRNLMKAILSGRAQIAKAVNATVISLDDAPKGYSDFD KGAAKKFVIDPHGTLK*" gene complement(3956305..3957531) /gene="yycR" /locus_tag="BSU_40250" /old_locus_tag="BSU40250" downshifts complement(3956320) /Source="Nicolas_upshifts" /id="D2083" /incds=0 /nref=9 /ntot=123 /MaxReadThrough="0.14321" /MaxDrop="4.77892" /score="8.82768619" /energy="-6.2" /TU="NA" /idTUdmin="U3169" /TUdmin=7 /isTUend="TRUE" promotor_-10 complement(3957554..3957572) /Source="Nicolas_upshift_promotors" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3957559) /Source="Nicolas_upshifts" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" promotor_-35 complement(3957584..3957592) /Source="Nicolas_upshift_promotors" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3957594..3957764) /gene="yyzG" /locus_tag="BSU_40259" /old_locus_tag="BSU40259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097801.1" /db_xref="EnsemblGenomes-Gn:BSU40259" /db_xref="EnsemblGenomes-Tr:CAX52716" /db_xref="GOA:C0H3U0" /db_xref="UniProtKB/Swiss-Prot:C0H3U0" /translation="MQTNRVILLAVMICLVSAITVFLLNGCKVDFLDIGGTIIGCFLG IFVVVRIQKKQS*" gene complement(3957594..3957764) /gene="yyzG" /locus_tag="BSU_40259" /old_locus_tag="BSU40259" promotor_-10 complement(3957783..3957801) /Source="Nicolas_upshift_promotors" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3957801) /Source="Nicolas_upshifts" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" promotor_-35 complement(3957815..3957821) /Source="Nicolas_upshift_promotors" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3957869..3958117) /gene="yycQ" /locus_tag="BSU_40260" /old_locus_tag="BSU40260" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_391906.1" /db_xref="EnsemblGenomes-Gn:BSU40260" /db_xref="EnsemblGenomes-Tr:CAB16063" /db_xref="GOA:Q45605" /db_xref="InterPro:IPR020258" /db_xref="SubtiList:BG11470" /db_xref="UniProtKB/Swiss-Prot:Q45605" /translation="MGAIAVLFIVFGFPIVAGVFGIAGHFLFKRFWVAPLIVLITSLI LLVTLASGNSSFIFWVVMYTAIALVTSVATLFLRKFFE*" gene complement(3957869..3958117) /gene="yycQ" /locus_tag="BSU_40260" /old_locus_tag="BSU40260" CDS complement(3958133..3959296) /gene="yycP" /locus_tag="BSU_40270" /old_locus_tag="BSU40270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11557812, 16291680" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391907.2" /db_xref="EnsemblGenomes-Gn:BSU40270" /db_xref="EnsemblGenomes-Tr:CAB16064" /db_xref="InterPro:IPR011047" /db_xref="SubtiList:BG11469" /db_xref="UniProtKB/Swiss-Prot:Q45606" /translation="MKKWMITIAMLILAGIALFVFISPLKSHKTVSQQDLRNPDFLDD KEVLLYFSSSADQDAFGGGKSYALFISHDGTLSSFQMKGLELGSAKVHGDSVMLEDKN TIYTIKNGLRSHKRTYQHTGDSAGFLQNTDGFYTLYNSGYDKKGDGYRSELYRQMDGE WKKDVIPYYIRASGFHDGAIYALVPTDDGKGYQLLQIQADQKKLTYLSITEWQYREGA SVESQLAVDDQAVYVMVRGQKAHDLYQMVKINKKSGEVELHDIAEYKNDEQTIYSSMP FSFKNSFFPYDGNLYFIDGFGKVHKIDAKTGKTSIVFTLSPDKMKAEFKEITQKGSSL YFFTYTYHKPAYIEQYSLKTGKKMKEKEIGKVKDVVTPKSHLKLYDVEVMKRF*" gene complement(3958133..3959296) /gene="yycP" /locus_tag="BSU_40270" /old_locus_tag="BSU40270" promotor_-10 complement(3958167..3958185) /Source="Nicolas_upshift_promotors" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3958175) /Source="Nicolas_upshifts" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" promotor_-35 complement(3958197..3958205) /Source="Nicolas_upshift_promotors" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3959307..3960044) /gene="yycO" /locus_tag="BSU_40280" /old_locus_tag="BSU40280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16291680" /codon_start=1 /transl_table=11 /product="conserved exported protein" /protein_id="NP_391908.1" /db_xref="EnsemblGenomes-Gn:BSU40280" /db_xref="EnsemblGenomes-Tr:CAB16065" /db_xref="SubtiList:BG11468" /db_xref="UniProtKB/Swiss-Prot:Q45607" /translation="MKLKKRVSMFLVALTMCGGLFVTPAKAVKTTNYAEEIAALQPGT TPEEIMKSASQIAKQQHVKQDVILKQFYKEITADKAEGDRLAKESGMSIMGGSSGTKK LPTSAKGNIYYTNSYTAYYNHGHVGMYSAADKIVESVPSDGVRQIAYNARDVEDNSIV QTVSVSSSQKTAAADWAVSKVGDPYSFNFVNNRNTGHDGAKNCSKLLWSAFLLKAGID IDSNGGLGVYPRDITSSSYTTTIMTIY*" gene complement(3959307..3960044) /gene="yycO" /locus_tag="BSU_40280" /old_locus_tag="BSU40280" promotor_-10 complement(3960086..3960104) /Source="Nicolas_upshift_promotors" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3960092) /Source="Nicolas_upshifts" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" promotor_-35 complement(3960118..3960126) /Source="Nicolas_upshift_promotors" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3960186..3960656) /gene="yycN" /locus_tag="BSU_40290" /old_locus_tag="BSU40290" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14635137, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_391909.1" /db_xref="EnsemblGenomes-Gn:BSU40290" /db_xref="EnsemblGenomes-Tr:CAB16066" /db_xref="GOA:O32293" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1ON0" /db_xref="PDB:1UFH" /db_xref="SubtiList:BG11467" /db_xref="UniProtKB/Swiss-Prot:O32293" /translation="MTIMLTPMQTEEFRSYLTYTTKHYAEEKVKAGTWLPEDAQLLSK QVFTDLLPRGLETPHHHLWSLKLNEKDIVGWLWIHAEPEHPQQEAFIYDFGLYEPYRG KGYAKQALAALDQAARSMGIRKLSLHVFAHNQTARKLYEQTGFQETDVVMSKKL*" gene complement(3960186..3960656) /gene="yycN" /locus_tag="BSU_40290" /old_locus_tag="BSU40290" downshifts complement(3960199) /Source="Nicolas_upshifts" /id="D2084" /incds=0 /nref=1 /ntot=78 /MaxReadThrough="3.78599" /MaxDrop="2.94893" /score="8.04802973" /energy="-7.6" /TU="U3175" /idTUdmin="U3174" /TUdmin=0 /isTUend="TRUE" S_feature complement(3960657..3960727) /Source="Nicolas_S_feature" /locus_tag="new_4140150_4140220_c" /HighExp="S4, S5, S6, LoTm, S3, S7, S8, B36, BT, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1549" promotor_-35 3960688..3960694 /Source="Nicolas_upshift_promotors" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3960708..3960727 /Source="Nicolas_upshift_promotors" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3960709..3960728) /Source="Nicolas_upshift_promotors" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3960709 /Source="Nicolas_upshifts" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" upshifts complement(3960727) /Source="Nicolas_upshifts" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" S_feature complement(3960729..3961004) /Source="Nicolas_S_feature" /locus_tag="new_4140222_4140497_c" /HighExp="S4, S5, S6, S7, S8, S3, B36, BT, LoTm, T5.0H" /AntisenseName="rapG" /AntisenseCor="-0.20647217228472101" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1550" promotor_-35 complement(3960743..3960750) /Source="Nicolas_upshift_promotors" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3960767..3961864 /gene="rapG" /locus_tag="BSU_40300" /old_locus_tag="BSU40300" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950930, 16553878" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950930, 16553878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391910.1" /db_xref="EnsemblGenomes-Gn:BSU40300" /db_xref="EnsemblGenomes-Tr:CAB16067" /db_xref="GOA:O32294" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11466" /db_xref="UniProtKB/Swiss-Prot:O32294" /translation="MNKIAPAEIASMLNDWYLAIKKHEVEESSRLFEEVKPLLDDMEE DQEVLAYFSLLELRHKVLLHEARGQGFQHEEPSHMNATSDMLKYYFFLFEGMYEAYKN NYDIAIGLYKDAEQYLDNIPDPIEKAEFHLKVGKLYYKLGQNIVSLNHTRQAVKTFRE ETDYKKKLASALITMSGNFTEMSQFEEAEAYLDEAIRITSELEDHFFEAQLLHNFGLL HAQSGKSEEAVSKLEEALQNDEYARSAYYYHSAYLLIRELFKIKKKEQALSYYQDVKE KLTAEPNRICEAKIDILYAIYAEGGHAETFHLCKQHMDDLLSEKEYDSVRELSILAGE RYRELELYKEAAHFFYEALQIEELIKRTEVI*" gene 3960767..3961864 /gene="rapG" /locus_tag="BSU_40300" /old_locus_tag="BSU40300" promotor_-10 complement(3960995..3961013) /Source="Nicolas_upshift_promotors" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="promotor_-10" upshifts complement(3961004) /Source="Nicolas_upshifts" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" promotor_-35 complement(3961028..3961033) /Source="Nicolas_upshift_promotors" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="promotor_-35" promotor_-35 3961588..3961596 /Source="Nicolas_upshift_promotors" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3961608..3961626 /Source="Nicolas_upshift_promotors" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3961621 /Source="Nicolas_upshifts" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" CDS 3961865..3961981 /gene="phrG" /locus_tag="BSU_40310" /old_locus_tag="BSU40310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950930, 16553878, 16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950930, 16553878, 16816200; Product type r: regulator" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapG" /protein_id="NP_391911.1" /db_xref="EnsemblGenomes-Gn:BSU40310" /db_xref="EnsemblGenomes-Tr:CAB16068" /db_xref="InterPro:IPR030968" /db_xref="SubtiList:BG11465" /db_xref="UniProtKB/Swiss-Prot:O32295" /translation="MKRFLIGAGVAAVILSGWFIADHQTHSQEMKVAEKMIG*" gene 3961865..3961981 /gene="phrG" /locus_tag="BSU_40310" /old_locus_tag="BSU40310" downshifts 3961970 /Source="Nicolas_upshifts" /id="D2085" /incds=0 /nref=39 /ntot=249 /MaxReadThrough="4.8963" /MaxDrop="7.30713" /score="31.0184314" /energy="-13.7" /TU="U3173,U3176" /idTUdmin="U3173" /TUdmin="-45" /isTUend="FALSE" CDS complement(3962218..3963108) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" /EC_number="3.5.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginase" /protein_id="NP_391912.1" /db_xref="EnsemblGenomes-Gn:BSU40320" /db_xref="EnsemblGenomes-Tr:CAB16069" /db_xref="GOA:P39138" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR014033" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG10932" /db_xref="UniProtKB/Swiss-Prot:P39138" /translation="MDKTISVIGMPMDLGQARRGVDMGPSAIRYAHLIERLSDMGYTV EDLGDIPINREKIKNDEELKNLNSVLAGNEKLAQKVNKVIEEKKFPLVLGGDHSIAIG TLAGTAKHYDNLGVIWYDAHGDLNTLETSPSGNIHGMPLAVSLGIGHESLVNLEGYAP KIKPENVVIIGARSLDEGERKYIKESGMKVYTMHEIDRLGMTKVIEETLDYLSACDGV HLSLDLDGLDPNDAPGVGTPVVGGISYRESHLAMEMLYDAGIITSAEFVEVNPILDHK NKTGKTAVELVESLLGKKLL*" gene complement(3962218..3963108) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" downshifts complement(3962224) /Source="Nicolas_upshifts" /id="D2086" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.33097" /MaxDrop="3.38667" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-89" /isTUend="FALSE" downshifts complement(3962286) /Source="Nicolas_upshifts" /id="D2087" /incds=1 /nref=28 /ntot=201 /MaxReadThrough="5.16507" /MaxDrop="5.79932" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-151" /isTUend="FALSE" CDS complement(3963182..3964585) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7540694, 10648515, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 10648515, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arginine/ornithine/gamma-aminobutyrate permease" /protein_id="NP_391913.1" /db_xref="EnsemblGenomes-Gn:BSU40330" /db_xref="EnsemblGenomes-Tr:CAB16070" /db_xref="GOA:P39137" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10933" /db_xref="UniProtKB/Swiss-Prot:P39137" /translation="MNTNQDNGNQLQRTMKSRHLFMISLGGVIGTGFFLGTGFTINQA GPLGAVLSYLVGGFIMFLTMLCLGELAVAFPVSGSFQTYATKFISPAFGFAFGWLYWL GWAVTCAIEFLSAGQLMQRWFPHIDVWIWCLVFAALMFILNAITTKAFAESEFWFSGI KILIILLFIILGGAAMFGLIDLKGGEQAPFLTHFYEDGLFPNGIKAMLITMITVNFAF QGTELIGVAAGESEDPEKTIPRSIKQTVWRTLVFFVLSIIVIAGMIPWKQAGVVESPF VAVFEQIGIPYAADIMNFVILIALLSVANSGLYASTRILYAMANEGQAFKALGKTNQR GVPMYSLIVTMAVACLSLLTKFAQAETVYMVLLSLAGMSAQVGWITISLSQIMFRRKY IREGGKIEDLKFKTPLYPVLPLIGLTLNTVVLISLAFDPEQRIALYCGVPFMIICYII YHVVIKKRQQANRQLEL*" gene complement(3963182..3964585) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" S_feature complement(3964586..3964807) /Source="Nicolas_S_feature" /locus_tag="new_4144079_4144300_c" /HighExp="Lbstat, S0, LPh, T1.30H, HPh, T2.0H, LPhT, BI, M0t90, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.884" /TUlongSig="NA" /TUlongPSig="NA" /label="S1551" CDS complement(3964808..3966013) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" /EC_number="2.6.1.13" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7540694, 9383188, 22720735, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 9383188, 22720735, 23869754; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine aminotransferase" /protein_id="NP_391914.1" /db_xref="EnsemblGenomes-Gn:BSU40340" /db_xref="EnsemblGenomes-Tr:CAB16071" /db_xref="GOA:P38021" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR010164" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR034757" /db_xref="SubtiList:BG10722" /db_xref="UniProtKB/Swiss-Prot:P38021" /translation="MTALSKSKEIIDQTSHYGANNYHPLPIVISEALGAWVKDPEGNE YMDMLSAYSAVNQGHRHPKIIQALKDQADKITLTSRAFHNDQLGPFYEKTAKLTGKEM ILPMNTGAEAVESAVKAARRWAYEVKGVADNQAEIIACVGNFHGRTMLAVSLSSEEEY KRGFGPMLPGIKLIPYGDVEALRQAITPNTAAFLFEPIQGEAGIVIPPEGFLQEAAAI CKEENVLFIADEIQTGLGRTGKTFACDWDGIVPDMYILGKALGGGVFPISCIAADREI LGVFNPGSHGSTFGGNPLACAVSIASLEVLEDEKLADRSLELGEYFKSELESIDSPVI KEVRGRGLFIGVELTEAARPYCERLKEEGLLCKETHDTVIRFAPPLIISKEDLDWAIE KIKHVLRNA*" gene complement(3964808..3966013) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" misc_feature complement(3966070..3966088) /Source="Nicolas_upshift_promotors" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3966073) /Source="Nicolas_upshifts" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" promotor_-35 3966183..3966188 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3966203..3966222 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3966218 /Source="Nicolas_upshifts" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" CDS 3966254..3967639 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9194709, 12533460, 12634342, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9194709, 12533460, 12634342, 23869754; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NtrC/NifA family)" /protein_id="NP_391915.1" /db_xref="EnsemblGenomes-Gn:BSU40350" /db_xref="EnsemblGenomes-Tr:CAB16072" /db_xref="GOA:P38022" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG10723" /db_xref="UniProtKB/Swiss-Prot:P38022" /translation="MVKDSEFLTLVFQSILDEIDVGLHVVDEHGNTIVYNNKMMQIED MEKHDVLNKNLMDVFMFSKQQDSTLVQALQEGKTIKNVKQSYFNNKGQEITTINHTYP IVQDGKIRGAVEIAKDVTKLERLIRENMNKKGSTTYTFDSILGTSPAIQDVIENAKRA TRTSSSVLLAGETGTGKELFAQSIHNGSDRSGGPFISQNCAALPDSLVESILFGTKKG AFTGAVDQPGLFEQAHGGTLLLDEINSLNLSLQAKLLRALQERKIRRIGSTKDTPIDV RIIATMNEDPIDAIAGERMRKDLYYRLSVVTLIIPPLRERKEDILLLASEFIQKNNHL FQMNVEHISDDVKQFFLSYDWPGNIRELEHMIEGAMNFMTDEQTITASHLPYQYRMKI KPADIPEPETPRHQPAADLKEKMESFEKYVIENVLRKHGHNISKAAQELGISRQSLQY RLKKFSHSSNE*" gene 3966254..3967639 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" CDS complement(3967621..3967809) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17198402; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="fragment of putative sensor protein" /db_xref="PSEUDO:CAX52717.1" /translation="MFDRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIG RGTVFLIRLPAPDYSLDE*" gene complement(3967621..3967809) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /pseudo CDS complement(3967926..3968054) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514013.1" /translation="MPGCFDMQKKLNRGHARSVEKGYIEYEEKYKMDVTRETANGS*" gene complement(3967926..3968054) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" downshifts 3967978 /Source="Nicolas_upshifts" /id="D2088" /incds=0 /nref=1 /ntot=146 /MaxReadThrough="0.86899" /MaxDrop="2.90385" /score="20.2816165" /energy="-10.8" /TU="NA" /idTUdmin="U3178" /TUdmin=110 /isTUend="FALSE" CDS complement(3968074..3969276) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" /EC_number="3.4.21.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 16030236, 25384476" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 16030236, 25384476; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation membrane serine protease" /protein_id="NP_391916.1" /db_xref="EnsemblGenomes-Gn:BSU40360" /db_xref="EnsemblGenomes-Tr:CAB16073" /db_xref="GOA:P39668" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG11054" /db_xref="UniProtKB/Swiss-Prot:P39668" /translation="MVDYEREEEHTTPEQPKRSKKGYFLSSLIGVIVGAVLMAFIMPY LSNEGLDTGALDQQQNNNGRESIRTVNVSVNNAVTKIVSNMSPAVVGVVNIQKSDIWG ESGEAGSGSGVIYKKNDHSAYVVTNHHVIEGASQIEISLKDGSRVSADLVGSDQLMDL AVLRVKSDKIKAVADFGNSDKVKSGEPVIAIGNPLGLEFAGSVTQGVISGTERAIPVD SNGDGQPDWNAEVLQTDAAINPGNSGGALLNMDGKVIGINSMKIAESAVEGIGLSIPS KLVIPVIEDLERYGKVKRPFLGIEMKSLSDIASYHWDETLKLPKNVTNGAVVMGVDAF SPAGKAGLKELDVITEFDGYKVNDIVDLRKRLYQKKVGDRVKVKFYRGGKEKSVDIKL SSADQLGS*" gene complement(3968074..3969276) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" downshifts complement(3968098) /Source="Nicolas_upshifts" /id="D2089" /incds=0 /nref=134 /ntot=253 /MaxReadThrough="2.3073" /MaxDrop="5.06813" /score="5.6507537" /energy="-15" /TU="NA" /idTUdmin="U3179" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3969308..3969319) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3969308) /Source="Nicolas_upshifts" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" promotor_-35 complement(3969334..3969340) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3969358..3970152) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9829949, 16030236, 21169496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391917.2" /db_xref="EnsemblGenomes-Gn:BSU40370" /db_xref="EnsemblGenomes-Tr:CAB16074" /db_xref="GOA:C0SP91" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11464" /db_xref="UniProtKB/Swiss-Prot:C0SP91" /translation="MSLQFSVLASGSTGNAFYLETEDHAFLVDAGLSGKAMDGLMAQI GRKLDDVDGIFVTHEHSDHIKGLGVVARKYKLPIYANEKTWKAMENQIGKIDTDQKFV FPMETVKSFGGLDVESFGVSHDAAEPMFYVFHYSGRKLALMTDTGYVSDRMKGIIRSA NVFVFESNHDVGMLQMGRYPWSIKRRILSDVGHVSNEDAALAMTDVIGDETSRIYLAH LSQDNNMKELARMSVQQTLASKGFVTGETFDLYDTDPKKATPLCAV*" gene complement(3969358..3970152) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" CDS complement(3970174..3971016) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 17307848, 17307850, 18408157, 21219466" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 17307848, 17307850, 18408157, 21219466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK" /protein_id="NP_391918.1" /db_xref="EnsemblGenomes-Gn:BSU40380" /db_xref="EnsemblGenomes-Tr:CAB16075" /db_xref="GOA:Q45612" /db_xref="InterPro:IPR018604" /db_xref="PDB:2O3O" /db_xref="SubtiList:BG11463" /db_xref="UniProtKB/Swiss-Prot:Q45612" /translation="MEWNKTKSIFIVAFLILDIFLGYQFFQKWQATGKEYEVIKNDVE HDMKADHITYEGLNKEATEGYRITANQKSFSKEEIEALKDQKPLMDMPSDDHKVTSLK MKFANPIALSKKDIEDDAQALVSSKIQDGEKYKLWKVDKSKKEIIFFQTYEGHYIYQK TDNPSNMIGQVVLHLNGKNEVVSYDQTTLETFKQIQKESLITEMDAVELLYYQNQLKE YSTVKSCKFGYVAQYPLTSTQVLAPVWRITVEYEKKVNGEKKTVQEYFTVNALESTIL DTDQ*" gene complement(3970174..3971016) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" CDS complement(3971003..3972370) /gene="walH" /locus_tag="BSU_40390" /old_locus_tag="BSU40390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 16600972, 17307850, 26999783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 16600972, 17307850, 26999783; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK(YycFG)" /protein_id="NP_391919.1" /db_xref="EnsemblGenomes-Gn:BSU40390" /db_xref="EnsemblGenomes-Tr:CAB16076" /db_xref="GOA:Q794W0" /db_xref="InterPro:IPR009996" /db_xref="PDB:2FGT" /db_xref="SubtiList:BG11462" /db_xref="UniProtKB/Swiss-Prot:Q794W0" /translation="MKRENIKTILLTVLVVISLVFTWGIWTFQPNFSEGSSSTESTVR VKHKIEKTTQKLSETVRPRDMFIHDDGAHYKVDDNALYEEIWSDLPHWDVKGIKDISD QYDKAGFKSWFYGIGGSEAKLDLQFSDTIPIDIFQTLFKWSNQSFEYSSFDHILIPFN ETKANKKIYLVSYSKQLILEVTVESANYRNIMNDLKNRQSNMPAFSLFSIGSKKEFLL PNKPLTMDKKEFVTESIKTNTFKQALFSDPSIVREDSNYNNRNVLTDGISRLDVNLSQ RQVQFQQRNLVQSTSYQTGELIKKSQKYLEDTGSWTDHYQFFNINDSQQLSFYIFMDQ IPVINSTAKPFGATSAITVQWANDDILSYKRPNYSLGTNPIKTSETELMGGSEVKMLL SKQTAYDTDKIDQIFLAYQLVSTSTNDDPLVELEPVWAMKVNGKIVPITKDLLRKEGA NSGVE*" gene complement(3971003..3972370) /gene="walH" /locus_tag="BSU_40390" /old_locus_tag="BSU40390" CDS complement(3972360..3974195) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YycG]" /protein_id="NP_391920.1" /db_xref="EnsemblGenomes-Gn:BSU40400" /db_xref="EnsemblGenomes-Tr:CAB16077" /db_xref="GOA:Q45614" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3SL2" /db_xref="SubtiList:BG11461" /db_xref="UniProtKB/Swiss-Prot:Q45614" /translation="MNKVGFFRSIQFKITLIYVLLIIIAMQIIGVYFVNQVEKSLISS YEQSLNQRIDNLSYYIEQEYKSDNDSTVIKDDVSRILNDFTKSDEVREISFVDKSYEV VGSSKPYGEEVAGKQTTDLIFKRIFSTKQSYLRKYYDPKSKIRVLISAKPVMTENQEV VGAIYVVASMEDVFNQMKTINTILASGTGLALVLTALLGIFLARTITHPLSDMRKQAM ELAKGNFSRKVKKYGHDEIGQLATTFNHLTRELEDAQAMTEGERRKLASVIAYMTDGV IATNRNGAIILLNSPALELLNVSRETALEMPITSLLGLQENYTFEDLVEQQDSMLLEI ERDDELTVLRVNFSVIQREHGKIDGLIAVIYDVTEQEKMDQERREFVANVSHELRTPL TTMRSYLEALAEGAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNRE WIQIVRFMSLIIDRFEMTKEQHVEFIRNLPDRDLYVEIDQDKITQVLDNIISNALKYS PEGGHVTFSIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGL GLAIAKEMVQAHGGDIWADSIEGKGTTITFTLPYKEEQEDDWDEA*" gene complement(3972360..3974195) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" CDS complement(3974203..3974910) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YycF]" /protein_id="NP_391921.1" /db_xref="EnsemblGenomes-Gn:BSU40410" /db_xref="EnsemblGenomes-Tr:CAB16078" /db_xref="GOA:P37478" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2D1V" /db_xref="PDB:2ZWM" /db_xref="PDB:3F6P" /db_xref="SubtiList:BG10001" /db_xref="UniProtKB/Swiss-Prot:P37478" /translation="MDKKILVVDDEKPIADILEFNLRKEGYEVHCAHDGNEAVEMVEE LQPDLILLDIMLPNKDGVEVCREVRKKYDMPIIMLTAKDSEIDKVIGLEIGADDYVTK PFSTRELLARVKANLRRQLTTAPAEEEPSSNEIHIGSLVIFPDAYVVSKRDETIELTH REFELLHYLAKHIGQVMTREHLLQTVWGYDYFGDVRTVDVTVRRLREKIEDNPSHPNW IVTRRGVGYYLRNPEQD*" gene complement(3974203..3974910) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" S_feature complement(3974911..3975007) /Source="Nicolas_S_feature" /locus_tag="new_4154404_4154500_c" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, dia0, LBGstat, dia5, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="1, 1, 0.11" /TUlongSig="SigA" /TUlongPSig="0.986" /label="S1552" promotor_-10 complement(3974995..3975014) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3975007) /Source="Nicolas_upshifts" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" S_feature complement(3975009..3975201) /Source="Nicolas_S_feature" /locus_tag="new_4154502_4154694_c" /HighExp="G180, Paraq, Oxctl, G135, G150, H2O2, T0.30H, BMM, Cold, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="0.986, 1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1553" promotor_-35 complement(3975030..3975033) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3975201) /Source="Nicolas_upshifts" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" misc_feature complement(3975211..3975230) /Source="Nicolas_upshift_promotors" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3975293) /Source="Nicolas_upshifts" /id="D2090" /incds=0 /nref=8 /ntot=83 /MaxReadThrough="5.21091" /MaxDrop="5.81799" /score="24.1725164" /energy="-10.6" /TU="U3183,U3184" /idTUdmin="U3181" /TUdmin="-264" /isTUend="FALSE" tRNA complement(3975294..3975366) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(3975294..3975366) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" tRNA complement(3975402..3975478) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(3975402..3975478) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" S_feature complement(3975479..3975559) /Source="Nicolas_S_feature" /locus_tag="new_4154972_4155052_c" /HighExp="Oxctl, Heat, BMM, Paraq, UNK1, H2O2, C30, MG 45, G180, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1554" tRNA complement(3975560..3975631) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(3975560..3975631) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" tRNA complement(3975641..3975716) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(3975641..3975716) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" misc_feature 3975688..3975704 /Source="Nicolas_upshift_promotors" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3975701 /Source="Nicolas_upshifts" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(3975717..3975813) /Source="Nicolas_S_feature" /locus_tag="new_4155210_4155306_c" /HighExp="LBGstat, C30, UNK1, Oxctl, HPh, Heat, MG 150, BMM, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1555" promotor_-10 complement(3975797..3975816) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3975813) /Source="Nicolas_upshifts" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" promotor_-35 complement(3975830..3975837) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(3975847..3975947) /Source="Nicolas_upshift_promotors" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3975887) /Source="Nicolas_upshifts" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" CDS complement(3975940..3977232) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" /EC_number="6.3.4.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1312531, 10368157, 16163456, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1312531, 10368157, 16163456, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate synthetase" /protein_id="NP_391922.1" /db_xref="EnsemblGenomes-Gn:BSU40420" /db_xref="EnsemblGenomes-Tr:CAB16079" /db_xref="GOA:P29726" /db_xref="InterPro:IPR001114" /db_xref="InterPro:IPR018220" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033128" /db_xref="SubtiList:BG10002" /db_xref="UniProtKB/Swiss-Prot:P29726" /translation="MSSVVVVGTQWGDEGKGKITDFLSENAEVIARYQGGNNAGHTIK FDGITYKLHLIPSGIFYKDKTCVIGNGMVVDPKALVTELAYLHERNVSTDNLRISNRA HVILPYHLKLDEVEEERKGANKIGTTKKGIGPAYMDKAARIGIRIADLLDRDAFAEKL ERNLEEKNRLLEKMYETEGFKLEDILDEYYEYGQQIKKYVCDTSVVLNDALDEGRRVL FEGAQGVMLDIDQGTYPFVTSSNPVAGGVTIGSGVGPTKIKHVVGVSKAYTTRVGDGP FPTELKDEIGDQIREVGREYGTTTGRPRRVGWFDSVVVRHARRVSGITDLSLNSIDVL AGIETLKICVAYRYKGEIIEEFPASLKALAECEPVYEEMPGWTEDITGAKSLSELPEN ARHYLERVSQLTGIPLSIFSVGPDRSQTNVLRSVYRAN*" gene complement(3975940..3977232) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" downshifts complement(3975951) /Source="Nicolas_upshifts" /id="D2091" /incds=0 /nref=200 /ntot=241 /MaxReadThrough="2.03104" /MaxDrop="6.53551" /score="13.9967927" /energy="-10.5" /TU="NA" /idTUdmin="U3185" /TUdmin=1 /isTUend="TRUE" promotor_-10 complement(3977272..3977291) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3977292) /Source="Nicolas_upshifts" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" promotor_-35 complement(3977306..3977313) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3977438..3977857) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16731985" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391923.1" /db_xref="EnsemblGenomes-Gn:BSU40430" /db_xref="EnsemblGenomes-Tr:CAB16080" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:1TWU" /db_xref="SubtiList:BG10003" /db_xref="UniProtKB/Swiss-Prot:P37479" /translation="MGKRFSSFQAAQIRIARPTGQLDEIIRFYEEGLCLKRIGEFSQH NGYDGVMFGLPHADYHLEFTQYEGGSTAPVPHPDSLLVFYVPNAVELAAITSKLKHMG YQEVESENPYWSNGGVTIEDPDGWRIVFMNSKGISGK*" gene complement(3977438..3977857) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" promotor_-10 complement(3977855..3977866) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3977866) /Source="Nicolas_upshifts" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" promotor_-35 complement(3977881..3977887) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3977978..3979342) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" /EC_number="3.6.4.12" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="replicative DNA helicase" /protein_id="NP_391924.2" /db_xref="EnsemblGenomes-Gn:BSU40440" /db_xref="EnsemblGenomes-Tr:CAB16081" /db_xref="GOA:P37469" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR007692" /db_xref="InterPro:IPR007693" /db_xref="InterPro:IPR007694" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036185" /db_xref="SubtiList:BG10004" /db_xref="UniProtKB/Swiss-Prot:P37469" /translation="MTDLLNDRLPPQNIEAEQAVLGAIFLQPSALTLASEVLIPDDFY RMSHQKIYNAMLVLGDRGEPVDLVTVTSELANTDLLEEVGGISYLTDIANSVPTAANI EYYAKIVEEKSILRRLIRTATTIAQDGYTREDEVEDLLSEAEKTIMEVAQRKNTSAFQ NIKDVLVQTYDNIEQLHNRKGDITGIPTGFTELDRMTAGFQRNDLIIVAARPSVGKTA FALNIAQNVATKTDESVAIFSLEMGAEQLVMRMLCAEGNINAQNLRTGNLTEEDWGKL TMAMGSLSNSGIYIDDTPGIRVSEIRAKCRRLKQESGLGMILIDYLQLIQGSGRSKDN RQQEVSEISRELKSIARELQVPVIALSQLSRGVEQRQDKRPMMSDIRESGSIEQDADI VAFLYRDDYYDKETENKNIIEIIIAKQRNGPVGTVSLAFVKEYNKFVNLERRFDDAGV PPGA*" gene complement(3977978..3979342) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" downshifts complement(3977998) /Source="Nicolas_upshifts" /id="D2092" /incds=0 /nref=3 /ntot=107 /MaxReadThrough="1.37092" /MaxDrop="3.96365" /score="31.6981667" /energy="-12.6" /TU="NA" /idTUdmin="U3187" /TUdmin=0 /isTUend="TRUE" downshifts complement(3978042) /Source="Nicolas_upshifts" /id="D2093" /incds=1 /nref=9 /ntot=190 /MaxReadThrough="3.89737" /MaxDrop="3.21735" /score="31.6981667" /energy="-12.6" /TU="U3187" /idTUdmin="U3190" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3979373..3979392) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3979387) /Source="Nicolas_upshifts" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" promotor_-35 complement(3979407..3979409) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3979454..3979460 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-35" promotor_-10 3979475..3979493 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-10" upshifts 3979477 /Source="Nicolas_upshifts" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" CDS 3979512..3979712 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391925.1" /db_xref="EnsemblGenomes-Gn:BSU40450" /db_xref="EnsemblGenomes-Tr:CAB16082" /db_xref="InterPro:IPR018691" /db_xref="InterPro:IPR020086" /db_xref="SubtiList:BG10005" /db_xref="UniProtKB/Swiss-Prot:P37480" /translation="MIKKYAITPNVDADGWFIEVENVAPTALYTSKDAAIEKAKQVAK ENSPSKLVIYDQFKNVEEEHSF*" gene 3979512..3979712 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" downshifts 3979682 /Source="Nicolas_upshifts" /id="D2094" /incds=0 /nref=15 /ntot=43 /MaxReadThrough="4.45045" /MaxDrop="5.68737" /score="12.3008592" /energy="-9.5" /TU="U3188" /idTUdmin="U3188" /TUdmin="-352" /isTUend="FALSE" S_feature 3979727..3980048 /Source="Nicolas_S_feature" /locus_tag="new_4159220_4159541" /HighExp="Etha, C30, Salt, S6, S8, M9-stat, S7, Oxctl, Paraq, Heat" /AntisenseName="yyzB" /AntisenseCor="0.309580857935493" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1556" CDS complement(3979760..3979963) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391926.1" /db_xref="EnsemblGenomes-Gn:BSU40460" /db_xref="EnsemblGenomes-Tr:CAB16083" /db_xref="SubtiList:BG14171" /db_xref="UniProtKB/Swiss-Prot:O32296" /translation="MHAPLSLLKQMLKEHQIDTEKAVTFEEYIAMRLKLQELMGKFAS IGEWDLYQKAADLMMHIGIQWMK*" gene complement(3979760..3979963) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" S_feature complement(3979964..3980264) /Source="Nicolas_S_feature" /locus_tag="new_4159457_4159757_c" /HighExp="S6, S8, S7, S5, S4, BT, B36, T5.0H, S3, C30" /AntisenseName="yycC" /AntisenseCor="-0.77379453158709499" /AntisenseRegPval="-54.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.049" /TUlongSig="NA" /TUlongPSig="NA" /label="S1557" promotor_-35 3980029..3980032 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3980047..3980066 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3980050 /Source="Nicolas_upshifts" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" CDS 3980084..3980224 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28546427" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391927.1" /db_xref="EnsemblGenomes-Gn:BSU40470" /db_xref="EnsemblGenomes-Tr:CAB16084" /db_xref="InterPro:IPR025550" /db_xref="SubtiList:BG10006" /db_xref="UniProtKB/Swiss-Prot:P37481" /translation="MRPLQISAETAQKLAESLNLPLEQIMHMPQHILLAKMAELQKED KS*" gene 3980084..3980224 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" S_feature 3980225..3980296 /Source="Nicolas_S_feature" /locus_tag="new_4159718_4159789" /HighExp="Sw, LoTm, Gly, BC, HiOs, B60, S0, T-5.40H, LBGstat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig=1 /label="S1558" upshifts complement(3980272) /Source="Nicolas_upshifts" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" promotor_-10 complement(3980275..3980289) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3980297..3980301) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3980297..3981505 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25790494; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion ABC transporter (permease)" /protein_id="NP_391928.1" /db_xref="EnsemblGenomes-Gn:BSU40480" /db_xref="EnsemblGenomes-Tr:CAB16085" /db_xref="GOA:P37482" /db_xref="InterPro:IPR004747" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10007" /db_xref="UniProtKB/Swiss-Prot:P37482" /translation="MPHPHNKKIQSFWLITGIIFIAFNLRPAITSVGPVISSIRAELH MSNGAAGFLTALPLLSFAVLSPLAPKLGQRLGNERTLWLGLVILLIGVLTRSTGYTAA LFFGTALIGVGIAIGNVLLPSLIKHKYPEKPGIMISLYTTSMNIFAALASGVSVPLAT QMNGGWKQAFLLWGGLALLALLIWIPQLRHRDTANQTMKLQSSSIWASKMAWYVTIFM GLQSFLFYSSIAWFPEILRSHGIDTATAGWMVSLMQFASLPSTFLTPVLADRVKQQRG IVAALASVYLIGLCGLLAGGSHTLLAIWMIIIGIGQGSSISLALTLIGLRSENAQQAA ALSGMSQSFGYLLAAVGPIFVGYLFDQTHSWTMPIVLLIAALIVMGAAGQGAGRDRYI FQSEKQRNSA*" gene 3980297..3981505 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" downshifts 3981486 /Source="Nicolas_upshifts" /id="D2095" /incds=0 /nref=148 /ntot=242 /MaxReadThrough="3.65611" /MaxDrop="4.91246" /score="26.443484" /energy="-10.1" /TU="U3189" /idTUdmin="U3189" /TUdmin="-484" /isTUend="FALSE" CDS 3981610..3983667 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase" /protein_id="NP_391929.2" /db_xref="EnsemblGenomes-Gn:BSU40490" /db_xref="EnsemblGenomes-Tr:CAB16086" /db_xref="GOA:P37483" /db_xref="SubtiList:BG10008" /db_xref="UniProtKB/Swiss-Prot:P37483" /translation="MKTKRFDAALILILLAAAFLNTYHIWQDDTANQYYLAAVKSMTQ SFHNFFYASFDPSGFVTVDKPPVVLWIQTIFALIFGVHTWSVIIPQALAGVGSVFLLY RMVKPTFGVGAARIAALVMALTPIAVAVSRTNNIDSMLVFTLLLGSTCLLRAVKQGKL VWLLTAFALIGLAFNMKMMQAFMVLPAFVLFYLIASRVSLKKKIGSLLLSLVLLTGLS LSWAIAVDSASSSSRPYVGSSQTNSVLELAFGYNGTERLFGQTTGLAKGDMNAAGGGN MQNQDNMQAPNGNGSSFSQNGNQSFGNHSQAPQPPNGQTGALNGGGGTPPTGGNGPGN GGPGGGGGKSVNMFGTGDPGPLRLFQSALSGQISWMLPFSLIGLLGAIISWYRDRRGH AAKMKETLFWAAWLVPVAGFFSIAGFFHQYYLIMLAPPIAALSGIGWYTMHRLYKNNK DWSSYLLPAAVLITAVFQVYILSAYTSQIGSVWMYVLGLLGLGITLALLMLKRSHPFS KLLTIISLCVLLLTPVYWSATPLLYGGNSVLPESGPQLKGSANGGNMFSSEVDSGLLS YLRKHNTGEEYLFATLTTVTAAPYIIYENESVMAMGGFNGTDPILTVSELKKLIKEGK VKYFLLSENNSGNSELVSWIKKNGKEITSDEYSGSSSSTNSVQGMRRGPGGESQQTLY LVE*" gene 3981610..3983667 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" downshifts 3983532 /Source="Nicolas_upshifts" /id="D2096" /incds=1 /nref=43 /ntot=203 /MaxReadThrough="1.96363" /MaxDrop="3.65354" /score="19.8733078" /energy="-16.6" /TU="NA" /idTUdmin="U3189" /TUdmin=1562 /isTUend="FALSE" CDS complement(3983704..3984153) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 23002217; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L9" /protein_id="NP_391930.1" /db_xref="EnsemblGenomes-Gn:BSU40500" /db_xref="EnsemblGenomes-Tr:CAB16087" /db_xref="GOA:P37437" /db_xref="InterPro:IPR000244" /db_xref="InterPro:IPR009027" /db_xref="InterPro:IPR020069" /db_xref="InterPro:IPR020070" /db_xref="InterPro:IPR020594" /db_xref="InterPro:IPR036791" /db_xref="InterPro:IPR036935" /db_xref="SubtiList:BG10009" /db_xref="UniProtKB/Swiss-Prot:P37437" /translation="MKVIFLQDVKGKGKKGEVKNVADGYAHNFLIKKGLAVEANASNI SALNGQKQKEKKEAIAELEQAKSLKETLEKLTVELSAKSGEGGRLFGSVTSKQITEQL QKDHNIKVDKRKLELPDGIRALGYTNVPVKLHPEVQAVLKVHVKEEA*" gene complement(3983704..3984153) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" downshifts complement(3983718) /Source="Nicolas_upshifts" /id="D2097" /incds=0 /nref=231 /ntot=266 /MaxReadThrough="2.69721" /MaxDrop="6.57383" /score="44.1169256" /energy="-16.6" /TU="NA" /idTUdmin="U3191" /TUdmin=0 /isTUend="TRUE" CDS complement(3984150..3986129) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" /EC_number="3.1.4.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphodiesterase acting on cyclic dinucleotides" /protein_id="NP_391931.1" /db_xref="EnsemblGenomes-Gn:BSU40510" /db_xref="EnsemblGenomes-Tr:CAB16088" /db_xref="GOA:P37484" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR014528" /db_xref="SubtiList:BG10010" /db_xref="UniProtKB/Swiss-Prot:P37484" /translation="MPSFYEKPLFRYPIYALIALSIITILISFYFNWILGTVEVLLLA VILFFIKRADSLIRQEIDAYISTLSYRLKKVGEEALMEMPIGIMLFNDQYYIEWANPF LSSCFNESTLVGRSLYDTCESVVPLIKQEVESETVTLNDRKFRVVIKRDERLLYFFDV TEQIQIEKLYENERTVLAYIFLDNYDDVTQGLDDQTRSTMNSQVTSLLNAWAQEYGIF LKRTSSERFIAVLNEHILTELENSKFSILDEVREKTSFDGVALTLSVGVGASVSSLKE LGDLAQSSLDLALGRGGDQVAIKLPNGKVKFYGGKTNPMEKRTRVRARVISHALKEIV TESSNVIIMGHKFPDMDSIGAAIGILKVAQANNKDGFIVIDPNQIGSSVQRLIGEIKK YEELWSRFITPEEAMEISNDDTLLVIVDTHKPSLVMEERLVNKIEHIVVIDHHRRGEE FIRDPLLVYMEPYASSTAELVTELLEYQPKRLKINMIEATALLAGIIVDTKSFSLRTG SRTFDAASYLRAKGADTVLVQKFLKETVDSYIKRAKLIQHTVLYKDNIAIASLPENEE EYFDQVLIAQAADSLLSMSEVEASFAVARRDEQTVCISARSLGEVNVQIIMEALEGGG HLTNAATQLSGISVSEALERLKHAIDEYFEGGVQR*" gene complement(3984150..3986129) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" misc_feature complement(3984631..3984650) /Source="Nicolas_upshift_promotors" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3984634) /Source="Nicolas_upshifts" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" promotor_-35 3985047..3985054 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3985068..3985086 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3985072..3985738 /Source="Nicolas_S_feature" /locus_tag="new_4164565_4165231" /HighExp="LBGstat, C30, Cold, GM 10, GM 25, GM 15, GM-0.1, GM 45, GM 120, GM 90" /AntisenseName="yybT" /AntisenseCor="0.145393098609886" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1559" upshifts 3985072 /Source="Nicolas_upshifts" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" CDS complement(3986166..3987095) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22956758; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391932.1" /db_xref="EnsemblGenomes-Gn:BSU40520" /db_xref="EnsemblGenomes-Tr:CAB16089" /db_xref="InterPro:IPR018710" /db_xref="SubtiList:BG10011" /db_xref="UniProtKB/Swiss-Prot:P37485" /translation="MKQTRALMEGAILISLFAIITLLVVYVPVIGTILLFALPLPMIL YTIRHGLKLGIWMGAVSLPVVFIVGSFNGLIVAFMSACAGIAMGHFFKRKEPGHAIIS GALIYMLSIVFYFVISIQFLGINIIDEAMTQYRQSLDIVETVAKQSGNAGQFEKQLKL MEEQLGIVQYLFPTAIVMVGVIFSFLSYLIAKPLLRRFSPDIPNLKPFRELKFPQSVV VLYLIIVMLSFLPLEKGQMLYSIALNGEFILGFLIFIQGLSFIFFYCHKKQYPKAAAV IAVILGFVHPVFMAAIRILGVLDMGFHIRNKVK*" gene complement(3986166..3987095) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" S_feature complement(3987096..3987232) /Source="Nicolas_S_feature" /locus_tag="new_4166589_4166725_c" /HighExp="H2O2, G150, G180, Cold, Paraq, G135, Oxctl, Salt, Etha, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1560" promotor_-10 complement(3987214..3987233) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3987232) /Source="Nicolas_upshifts" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" promotor_-35 complement(3987248..3987253) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3987322..3987471) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097802.1" /db_xref="EnsemblGenomes-Gn:BSU40529" /db_xref="EnsemblGenomes-Tr:CAX52718" /db_xref="GOA:C0H3U2" /db_xref="UniProtKB/Swiss-Prot:C0H3U2" /translation="MWDMIKNFFLFSSGVLQATTLLLVILIFMYVRKTKKKNKESSGF MDDKH*" gene complement(3987322..3987471) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" downshifts complement(3987348) /Source="Nicolas_upshifts" /id="D2098" /incds=0 /nref=1 /ntot=44 /MaxReadThrough="6.98636" /MaxDrop="3.23568" /score="-6.7107279" /energy="-8.4" /TU="U3194" /idTUdmin="U3197" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3987510..3987529) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-10" upshifts complement(3987527) /Source="Nicolas_upshifts" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" promotor_-35 complement(3987543..3987549) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-35" promotor_-35 3987550..3987559 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3987572..3987591 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3987578 /Source="Nicolas_upshifts" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" upshifts complement(3987590) /Source="Nicolas_upshifts" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(3987592..3988105) /Source="Nicolas_S_feature" /locus_tag="new_4167085_4167598_c" /HighExp="dia5, Diami, H2O2, Salt, dia15, Etha, Paraq, LPhT, G180, C30" /AntisenseName="cotF" /AntisenseCor="-0.33406696665100499" /AntisenseRegPval="-7.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1561" promotor_-10 complement(3987594..3987608) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3987617..3987621) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3987617..3988099 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1708381, 19933362, 23335421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1708381, 19933362, 23335421; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_391933.1" /db_xref="EnsemblGenomes-Gn:BSU40530" /db_xref="EnsemblGenomes-Tr:CAB16090" /db_xref="GOA:P23261" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="InterPro:IPR016493" /db_xref="SubtiList:BG10012" /db_xref="UniProtKB/Swiss-Prot:P23261" /translation="MDERRTLAWHETLEMHELVAFQSNGLIKLKKMIREVKDPQLRQL YNVSIQGVEQNLRELLPFFPQAPHREDEEEERADNPFYSGDLLGFAKTSVRSYAIAIT ETATPQLRNVLVKQLNAAIQLHAQVYRYMYQHGYYPSYNLSELLKNDVRNANRAISMK *" gene 3987617..3988099 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" downshifts 3988086 /Source="Nicolas_upshifts" /id="D2099" /incds=0 /nref=20 /ntot=52 /MaxReadThrough="5.45774" /MaxDrop="4.1869" /score="-3.60126456" /energy="-16.9" /TU="U3195" /idTUdmin="U3195" /TUdmin="-1540" /isTUend="FALSE" CDS complement(3988129..3988506) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22238377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22238377; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Cys-activated by oxidative stress)" /protein_id="NP_391934.1" /db_xref="EnsemblGenomes-Gn:BSU40540" /db_xref="EnsemblGenomes-Tr:CAB16091" /db_xref="GOA:P37486" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4A5M" /db_xref="PDB:4A5N" /db_xref="SubtiList:BG10013" /db_xref="UniProtKB/Swiss-Prot:P37486" /translation="MSEKKNIYPNKEGCPVEFTLDVIGGKWKGILFYHMIDGKKRFNE FRRICPSITQRMLTLQLRELEADGIVHREVYHQVPPKVEYSLTEFGRTLEPIVLQMKE WGESNRDVLESYRSNGLVKDQQK*" gene complement(3988129..3988506) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" S_feature 3988131..3988660 /Source="Nicolas_S_feature" /locus_tag="new_4167624_4168153" /HighExp="S8, S6, S7, BT, S5, B36, C30, B60, G/S, Pyr" /AntisenseName="yybR" /AntisenseCor="-0.26586375565089998" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1562" downshifts complement(3988150) /Source="Nicolas_upshifts" /id="D2100" /incds=0 /nref=124 /ntot=240 /MaxReadThrough="4.32896" /MaxDrop="5.38963" /score="10.6464065" /energy="-15.3" /TU="U3197" /idTUdmin="U3197" /TUdmin="-802" /isTUend="FALSE" promotor_-10 complement(3988561..3988580) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3988573) /Source="Nicolas_upshifts" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" promotor_-35 complement(3988594..3988601) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3988642..3988646 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3988660..3988679 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3988662 /Source="Nicolas_upshifts" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" promotor_-10 complement(3988687..3988701) /Source="Nicolas_upshift_promotors" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3988690) /Source="Nicolas_upshifts" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 3988711..3989640 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" /EC_number="3.6.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic pyrophosphatase (Mn2+-dependent)" /protein_id="NP_391935.1" /db_xref="EnsemblGenomes-Gn:BSU40550" /db_xref="EnsemblGenomes-Tr:CAB16092" /db_xref="GOA:P37487" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR004097" /db_xref="InterPro:IPR022934" /db_xref="PDB:1K23" /db_xref="PDB:1WPM" /db_xref="PDB:1WPN" /db_xref="PDB:2HAW" /db_xref="PDB:2IW4" /db_xref="SubtiList:BG10014" /db_xref="UniProtKB/Swiss-Prot:P37487" /translation="MEKILIFGHQNPDTDTICSAIAYADLKNKLGFNAEPVRLGQVNG ETQYALDYFKQESPRLVETAANEVNGVILVDHNERQQSIKDIEEVQVLEVIDHHRIAN FETAEPLYYRAEPVGCTATILNKMYKENNVKIEKEIAGLMLSAIISDSLLFKSPTCTD QDVAAAKELAEIAGVDAEEYGLNMLKAGADLSKKTVEELISLDAKEFTLGSKKVEIAQ VNTVDIEDVKKRQAELEAVISKVVAEKNLDLFLLVITDILENDSLALAIGNEAAKVEK AFNVTLENNTALLKGVVSRKKQVVPVLTDAMAE*" gene 3988711..3989640 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" promotor_-35 complement(3988715) /Source="Nicolas_upshift_promotors" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3989626 /Source="Nicolas_upshifts" /id="D2101" /incds=0 /nref=235 /ntot=270 /MaxReadThrough="2.06965" /MaxDrop="8.02492" /score="25.8885382" /energy="-11.7" /TU="NA" /idTUdmin="U3195" /TUdmin=0 /isTUend="TRUE" downshifts complement(3989669) /Source="Nicolas_upshifts" /id="D2102" /incds=0 /nref=14 /ntot=136 /MaxReadThrough="1.08899" /MaxDrop="4.94065" /score="19.3488922" /energy="-11.7" /TU="NA" /idTUdmin="U3200" /TUdmin=33 /isTUend="FALSE" CDS complement(3989673..3990119) /gene="yybP" /locus_tag="BSU_40560" /old_locus_tag="BSU40560" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15096624, 25794618, 25794619; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative manganese-binding lipoprotein" /protein_id="NP_391936.1" /db_xref="EnsemblGenomes-Gn:BSU40560" /db_xref="EnsemblGenomes-Tr:CAB16093" /db_xref="GOA:P37488" /db_xref="SubtiList:BG10015" /db_xref="UniProtKB/Swiss-Prot:P37488" /translation="MKIILTVLAGVGLLSAGGCGMLDQVNDGLNYTSEAAGYVEKVKT FAEEAPELAEKAVNDTEAKEKLEAQLESIQKAAADFNELTPPDAAAEIHRTIQEHNET LQKSAEDVLKQAEEGKVSLKELEQSDLVQNAKQITDVMGQIEKLGE*" gene complement(3989673..3990119) /gene="yybP" /locus_tag="BSU_40560" /old_locus_tag="BSU40560" S_feature complement(3990120..3990450) /Source="Nicolas_S_feature" /locus_tag="new_4169613_4169943_c" /HighExp="S8, Cold, S7, S6, H2O2, S5, S4, Etha, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.998614" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1563" misc_RNA complement(3990309..3990426) /gene="mswM" /locus_tag="BSU_misc_RNA_94" /product="manganese ion binding riboswitch" /experiment="publication(s) with functional evidences, PMID:25794618, 25794619" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25794618, 25794619; Product type n: RNA" gene complement(3990309..3990426) /gene="mswM" /locus_tag="BSU_misc_RNA_94" promotor_-10 complement(3990441..3990460) /Source="Nicolas_upshift_promotors" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3990449) /Source="Nicolas_upshifts" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" promotor_-35 complement(3990474..3990481) /Source="Nicolas_upshift_promotors" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3990487..3990493 /Source="Nicolas_upshift_promotors" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3990506 /Source="Nicolas_upshifts" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" promotor_-10 3990508..3990526 /Source="Nicolas_upshift_promotors" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3990522..3990528 /Source="Nicolas_upshift_promotors" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3990543..3990554 /Source="Nicolas_upshift_promotors" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3990550 /Source="Nicolas_upshifts" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" CDS 3990552..3991859 /gene="yybO" /locus_tag="BSU_40570" /old_locus_tag="BSU40570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_391937.1" /db_xref="EnsemblGenomes-Gn:BSU40570" /db_xref="EnsemblGenomes-Tr:CAB16094" /db_xref="GOA:P37489" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10016" /db_xref="UniProtKB/Swiss-Prot:P37489" /translation="MTEEVFIMSQERVKRPGHTRWYISSLLSGIIILNYFDRVAISVA APAIQDSFHLTATELGIVFSIYTYSYTLMQLPVGSLLDRFGVAWVTRVGMTIWSFLTI LLAFLQGKLLLYLFRFLIGLTSASAFPAASKATALWFPPSERGLANSLFDSAAKFSNV IGAPLVAFLVTTFDWRVAFLTIGCINVLFTIFFWQYYEQPERHKRISKSELNYIQKHN AITTEQIPYKTGPLLKKLFTNRKVWGLMIGFTGYGYTFNLLLTWLPTFFKHTYGMDLM SSGLFTAVPWLISTISGIAVGGWLVDYFIKKGYPNTKVYRTVIIVGMSFGFFFLGSIL TNNITVAIICISIGLAGISATAPVGWSISAELAPIGSVSMLSSMVNLANNLFGGIIAA SLTGYLFDVTGSFTLSFLVAGFVLLLGLVFYVFVLGDVKRIKL*" gene 3990552..3991859 /gene="yybO" /locus_tag="BSU_40570" /old_locus_tag="BSU40570" downshifts complement(3991660) /Source="Nicolas_upshifts" /id="D2103" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="0.73662" /MaxDrop="2.97868" /score="30.543563" /energy="-17.9" /TU="NA" /idTUdmin="U3203" /TUdmin=264 /isTUend="FALSE" downshifts 3991848 /Source="Nicolas_upshifts" /id="D2104" /incds=0 /nref=7 /ntot=55 /MaxReadThrough="2.76545" /MaxDrop="3.99898" /score="-3.44083304" /energy="-17.9" /TU="NA" /idTUdmin="U3201" /TUdmin=0 /isTUend="TRUE" CDS complement(3991903..3992142) /gene="yyzI" /locus_tag="BSU_40573" /old_locus_tag="BSU40573" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52719.1" /translation="MNYKKQNQGFGSISGDHNDIHDILATIEENGTQDAFHYEGGLQG KNEQVLEQIEQEMLASGLDIEEQDEEKVNGDGPIL*" gene complement(3991903..3992142) /gene="yyzI" /locus_tag="BSU_40573" /old_locus_tag="BSU40573" /pseudo downshifts complement(3991924) /Source="Nicolas_upshifts" /id="D2105" /incds=0 /nref=4 /ntot=114 /MaxReadThrough="3.05613" /MaxDrop="4.69729" /score="30.543563" /energy="-17.9" /TU="NA" /idTUdmin="U3203" /TUdmin=0 /isTUend="TRUE" promotor_no_box complement(3991928..3992028) /Source="Nicolas_upshift_promotors" /id="U3203" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.552447552447552" /psig="0.010989010989011" /xcortree=1485 /SigmaFactorBS="gaaggtggtcttcaaggaaaaaacgagcaggtgctcgaacag atagagcaggaaatgctagcttcggggcttgatatagaggaacaggacgaggagaagg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3991968) /Source="Nicolas_upshifts" /id="U3203" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.552447552447552" /psig="0.010989010989011" /xcortree=1485 /SigmaFactorBS="gaaggtggtcttcaaggaaaaaacgagcaggtgctcgaacag atagagcaggaaatgctagcttcggggcttgatatagaggaacaggacgaggagaagg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3992132..3992296) /gene="yyzJ" /locus_tag="BSU_40574" /old_locus_tag="BSU40574" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52720.1" /translation="MMIRGIHLEQQLKDIISACDVAIQNEDFDTLMNYYSERIMCKPR KQPPQRFCEL*" gene complement(3992132..3992296) /gene="yyzJ" /locus_tag="BSU_40574" /old_locus_tag="BSU40574" /pseudo CDS complement(3992308..3992493) /locus_tag="BSU_40576" /old_locus_tag="BSU40576" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514014.1" /translation="MSHQTKYPVNEAAIMPSNRLFARFTMELSMDTEPIGASSAEMDQ RNRKNKNEKDPYVSNIV*" gene complement(3992308..3992493) /locus_tag="BSU_40576" /old_locus_tag="BSU40576" downshifts 3992574 /Source="Nicolas_upshifts" /id="D2106" /incds=0 /nref=13 /ntot=90 /MaxReadThrough="0.18425" /MaxDrop="3.85413" /score="3.91893698" /energy="-13.7" /TU="NA" /idTUdmin="U3201" /TUdmin=726 /isTUend="FALSE" CDS complement(3992766..3992912) /gene="yyzK" /locus_tag="BSU_40578" /old_locus_tag="BSU40578" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52721.1" /translation="MYGKTIKKRLEKIAFLFQEISKKRKEKIERSFVGSKQLHGLSYR RFRG*" gene complement(3992766..3992912) /gene="yyzK" /locus_tag="BSU_40578" /old_locus_tag="BSU40578" /pseudo CDS complement(3992894..3993043) /gene="yyzL" /locus_tag="BSU_40579" /old_locus_tag="BSU40579" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52722.1" /translation="MLNQHTLTYSTIDRKDYRSYKSNPEICLRILHKINETPESRYSV CMAKP*" gene complement(3992894..3993043) /gene="yyzL" /locus_tag="BSU_40579" /old_locus_tag="BSU40579" /pseudo misc_feature complement(3993359..3993375) /Source="Nicolas_upshift_promotors" /id="U3204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.330669330669331" /psig="0.761238761238761" /xcortree=650 /SigmaFactorBS="agattaactatattatatcttaactgtaataacctgtaaaga attttattgatagtattggATTTTATGTTATAAAGGaaaaagggtgggcgatttgctc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3993376) /Source="Nicolas_upshifts" /id="U3204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.330669330669331" /psig="0.761238761238761" /xcortree=650 /SigmaFactorBS="agattaactatattatatcttaactgtaataacctgtaaaga attttattgatagtattggATTTTATGTTATAAAGGaaaaagggtgggcgatttgctc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 3993395..3993402 /Source="Nicolas_upshift_promotors" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3993417..3993620 /Source="Nicolas_S_feature" /locus_tag="new_4172910_4173113" /HighExp="nit, T-3.40H, T-1.40H, T-0.40H, T0.0H, SMMPr, SMM, LoTm, ferm, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1564" promotor_-10 3993417..3993436 /Source="Nicolas_upshift_promotors" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3993417 /Source="Nicolas_upshifts" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" misc_feature complement(3993438..3993452) /Source="Nicolas_upshift_promotors" /id="U3206" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=295 /SigmaFactorBS="tggggagatggagttactcctatttaaaacttcaacacaagt aataaaaaCCTCCTTTTACGTAAaagattaactatattatatcttaactgtaataacc t" /listShort="yyzL, yyzK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3993442) /Source="Nicolas_upshifts" /id="U3206" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=295 /SigmaFactorBS="tggggagatggagttactcctatttaaaacttcaacacaagt aataaaaaCCTCCTTTTACGTAAaagattaactatattatatcttaactgtaataacc t" /listShort="yyzL, yyzK" /GFF_Attribute="listLong" CDS 3993621..3994058 /gene="yybN" /locus_tag="BSU_40580" /old_locus_tag="BSU40580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27902860" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391938.1" /db_xref="EnsemblGenomes-Gn:BSU40580" /db_xref="EnsemblGenomes-Tr:CAB16095" /db_xref="InterPro:IPR020208" /db_xref="SubtiList:BG10017" /db_xref="UniProtKB/Swiss-Prot:P37490" /translation="MNKFLKSNFRFLLAAALGISLLASSNFIKASNDNYKFHLLVPYG YGNAYSNDAFRQTTHTDNPWKVNLQKSAEGKGTIMTFWLINTGNSKIPKASKIHNVKQ GSGAHYYHANSQGSHTYVALAVENNNYSASSYGIDGVWDEETW*" gene 3993621..3994058 /gene="yybN" /locus_tag="BSU_40580" /old_locus_tag="BSU40580" S_feature 3994059..3994135 /Source="Nicolas_S_feature" /locus_tag="new_4173552_4173628" /HighExp="M9-tran, SMMPr, MG 120, aero, GM 120, SMM, T-2.40H, T-4.40H, nit, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1565" downshifts 3994092 /Source="Nicolas_upshifts" /id="D2107" /incds=0 /nref=10 /ntot=98 /MaxReadThrough="6.91942" /MaxDrop="3.8662" /score="9.16494325" /energy="-9.5" /TU="U3205" /idTUdmin="U3201" /TUdmin=2244 /isTUend="FALSE" CDS 3994172..3994927 /gene="yybM" /locus_tag="BSU_40590" /old_locus_tag="BSU40590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391939.1" /db_xref="EnsemblGenomes-Gn:BSU40590" /db_xref="EnsemblGenomes-Tr:CAB16096" /db_xref="SubtiList:BG10018" /db_xref="UniProtKB/Swiss-Prot:P37491" /translation="MESHIYRIIKNKLTIIIFTIIILIPCVDISLLLMTNTEYHPAYA FFLSGTSVGHASQMILLWFLPLYFLLLCADDSIQDYKTGYHYILISKVGRKKYCLEKI FTSFIISFLTMFLSLILNFLLVQVFFFKGTFKNDLDQIKFPDNSLYTFSMAHPYIAIV LFSIICCIMSGFVGALGSSLSLLFRDKKYAYPASFFIWFVLILKNKSLMFLFQPFTEY GYNVLLPILCLSIFIFLIIISSIVLYEAKYNEN*" gene 3994172..3994927 /gene="yybM" /locus_tag="BSU_40590" /old_locus_tag="BSU40590" S_feature complement(3994767..3997357) /Source="Nicolas_S_feature" /locus_tag="new_4174260_4176850_c" /HighExp="S8, S6, S4, S5, S7, S3, C30, BT, G135, T5.0H" /AntisenseName="yybK" /AntisenseCor="-0.46686696237140402" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1566" CDS 3994917..3995627 /gene="yybL" /locus_tag="BSU_40600" /old_locus_tag="BSU40600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391940.1" /db_xref="EnsemblGenomes-Gn:BSU40600" /db_xref="EnsemblGenomes-Tr:CAB16097" /db_xref="SubtiList:BG10019" /db_xref="UniProtKB/Swiss-Prot:P37492" /translation="MKIKRLLLILCLLLFLVTLWFNQNHTYLGKNSIASLLYMNNSTF GYSSIFAYTLFYIVPFLMLLSNFFHSENPYKVMRMVKRKNYYKSKIMEIGFVSLLFSS IHTVINITCTHIFFSKNLLVEANFLSICLLNMISLVFFYLSVGIMFRLTYDLFNSVAL AIFIVYIILDSLYFGVKLLLPNGYWEPFRDLAIFTNMLNRYWSTSNLIIVYIRQIIIV FIFYLVGSSIFLNKDYKK*" gene 3994917..3995627 /gene="yybL" /locus_tag="BSU_40600" /old_locus_tag="BSU40600" downshifts 3995126 /Source="Nicolas_upshifts" /id="D2108" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="7.39982" /MaxDrop="2.95139" /score="9.16494325" /energy="-9.5" /TU="U3205" /idTUdmin="U3205" /TUdmin="-2354" /isTUend="FALSE" CDS 3995624..3996379 /gene="yybK" /locus_tag="BSU_40610" /old_locus_tag="BSU40610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391941.1" /db_xref="EnsemblGenomes-Gn:BSU40610" /db_xref="EnsemblGenomes-Tr:CAB16098" /db_xref="InterPro:IPR024295" /db_xref="SubtiList:BG10020" /db_xref="UniProtKB/Swiss-Prot:P37493" /translation="MRIKGFFITLVAIIFQASLSSYNNNKNVFPFLDGIPISTSGHYE YQNILLWFVPIVSLSFCFSGSIRDTYISYEQLKLVREHSRVKWVTSQFLIITVVLLIF TLSQIAIFYIYSLVSLHNLDINSVINKRFVMMTLMYYLTLLNLFSFQLFMELYYKSQI AQLNISVYIIFSLILAKKLVQLNSPKVIHYFLIPNYSNGLRTGLSYYSQSGTAIIEPL LGLFIIIILQISIVILSVLKFKKIDMLKSEGLQ*" gene 3995624..3996379 /gene="yybK" /locus_tag="BSU_40610" /old_locus_tag="BSU40610" CDS 3996376..3997032 /gene="yybJ" /locus_tag="BSU_40620" /old_locus_tag="BSU40620" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1938973; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-binding cassette subunit of transporter" /protein_id="NP_391942.1" /db_xref="EnsemblGenomes-Gn:BSU40620" /db_xref="EnsemblGenomes-Tr:CAB16099" /db_xref="GOA:P37494" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10021" /db_xref="UniProtKB/Swiss-Prot:P37494" /translation="MIEVLNLTKKIKKTTVLDNISYTFEKGTIYGLFGSNGSGKTMLL RALSGLIVPTEGSITIKGEQLHKDISFPKSVGLIIENMQLLPQYDAFTNLKILSKIKK IASDNDILDSISRVGLENFNSVKVSKFSLGMKQRLNIAQAIFEKPDILLLDEPTNAID EKGVAFVHDILLQEKKRGATIIITSHHKEDIISLCDIALEMNHGRLETSEKVIYKKDS *" gene 3996376..3997032 /gene="yybJ" /locus_tag="BSU_40620" /old_locus_tag="BSU40620" S_feature 3997033..3997347 /Source="Nicolas_S_feature" /locus_tag="new_4176526_4176840" /HighExp="aero, Cold, HPh, nit, M/G, M9-tran, S1, SMM, LPh, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1567" downshifts 3997304 /Source="Nicolas_upshifts" /id="D2109" /incds=0 /nref=93 /ntot=227 /MaxReadThrough="3.45614" /MaxDrop="4.54398" /score="2.19825508" /energy="-10.3" /TU="U3205" /idTUdmin="U3205" /TUdmin="-176" /isTUend="FALSE" downshifts 3997348 /Source="Nicolas_upshifts" /id="D2110" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.98662" /MaxDrop="3.29879" /score="2.19825508" /energy="-10.3" /TU="U3205" /idTUdmin="U3205" /TUdmin="-132" /isTUend="FALSE" downshifts complement(3997402) /Source="Nicolas_upshifts" /id="D2111" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="3.53364" /MaxDrop="2.25148" /score="10.1219981" /energy="-6.3" /TU="U3207" /idTUdmin="U3209" /TUdmin=2266 /isTUend="FALSE" CDS complement(3997407..3998195) /gene="ictI" /locus_tag="BSU_40630" /old_locus_tag="BSU40630" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16321932, 22882546, 25835496" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932, 22882546, 25835496; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391943.1" /db_xref="EnsemblGenomes-Gn:BSU40630" /db_xref="EnsemblGenomes-Tr:CAB16100" /db_xref="SubtiList:BG10022" /db_xref="UniProtKB/Swiss-Prot:P37495" /translation="MNVYDIRMAPYWFYEGRGLVQHPYVFRQPVSSRAIIVSTRGDVT GDGVIDEVFLTGNQMPGSPLWRNITLVIRDGRTHQEQRIQLQNNMGYNPSLFLGDMTG DKIEDVAVVMDTGGSGGAIYAYVFAYLNRQFRRIFNSDVLNDELKYSVRYQNQYKASV ISHQQNETYILDLTYKGREYLNEIYNSQGVLKMPIEGWVNPLSGLYPVDFDRDGVYEL LAYQRIAGRYNADSLGYVQTVLKWNGQRFMFNRQTVTIFGSDLS*" gene complement(3997407..3998195) /gene="ictI" /locus_tag="BSU_40630" /old_locus_tag="BSU40630" promotor_-10 complement(3998219..3998237) /Source="Nicolas_upshift_promotors" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3998238) /Source="Nicolas_upshifts" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" promotor_-35 complement(3998253..3998258) /Source="Nicolas_upshift_promotors" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3998263..3998652) /gene="yybH" /locus_tag="BSU_40640" /old_locus_tag="BSU40640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391944.1" /db_xref="EnsemblGenomes-Gn:BSU40640" /db_xref="EnsemblGenomes-Tr:CAB16101" /db_xref="InterPro:IPR009959" /db_xref="InterPro:IPR032710" /db_xref="PDB:2GXF" /db_xref="SubtiList:BG10023" /db_xref="UniProtKB/Swiss-Prot:P37496" /translation="MEQQLKDIISACDLAIQNEDFDTLMNYYSEDAVLVVKPGMIARG KEEIKKAFITIANYFNHHIVPTQGKMILLEAGDTVLVLSQTLLDSDKKDSEYAMERRA TYVFKKNAQGEWLCVIDNSYGTDLIGV*" gene complement(3998263..3998652) /gene="yybH" /locus_tag="BSU_40640" /old_locus_tag="BSU40640" promotor_-35 3998721..3998724 /Source="Nicolas_upshift_promotors" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3998739..3998758 /Source="Nicolas_upshift_promotors" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3998752 /Source="Nicolas_upshifts" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" CDS 3998798..3999637 /gene="yybG" /locus_tag="BSU_40650" /old_locus_tag="BSU40650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11709313, 12486061" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391945.1" /db_xref="EnsemblGenomes-Gn:BSU40650" /db_xref="EnsemblGenomes-Tr:CAB16102" /db_xref="InterPro:IPR001646" /db_xref="SubtiList:BG10024" /db_xref="UniProtKB/Swiss-Prot:P37497" /translation="MSAEVTLHDNIHYDLSADCQHCFGLCCVALPYAKSADFAFDKDG GTPCRNLQSNYQCSIHKDLREKGFRGCSAYECFGAGQKVSQITYEGKDWRNSPETANQ MFDVFPIMQQLHEMLWYLHEALSIDIAKPIHSELRTTFEKIERLTRLSKERLLTLQVD EHRAEVNEWLLKTSELVRAQARHPKLPKKVSRGSVLIGAKLKGLDLRGANLRGALLIA ADLRNADLRMTDFIGADMRDADLSGADLTGSIFLTQAQVNAANGDSNTKLPLSVRTPA HWK*" gene 3998798..3999637 /gene="yybG" /locus_tag="BSU_40650" /old_locus_tag="BSU40650" downshifts 3999614 /Source="Nicolas_upshifts" /id="D2112" /incds=0 /nref=35 /ntot=188 /MaxReadThrough="1.19247" /MaxDrop="3.72166" /score="-0.156630814" /energy="-6.3" /TU="NA" /idTUdmin="U3208" /TUdmin=0 /isTUend="TRUE" CDS complement(3999670..4000884) /gene="yybF" /locus_tag="BSU_40660" /old_locus_tag="BSU40660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811656, 11557812, 12486061, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_391946.1" /db_xref="EnsemblGenomes-Gn:BSU40660" /db_xref="EnsemblGenomes-Tr:CAB16103" /db_xref="GOA:P37498" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10025" /db_xref="UniProtKB/Swiss-Prot:P37498" /translation="MTYIRKGTPVFRKITFAFFAAGFNTFAILYCVQPLMEEFTREFH VTPTAASLSLSVTTMLLAVSMLVFGSLSEVWGRKPIMGISMLAASVLCLASAFSPSFH TLLVLRTIQGVALAGLPSIAMAYLGEEIEPGSLGSAMGLYISGNAIGAVFGRIVSGLL SEYLNWHMAMGTIGVISLIASVIFFINLPPSRHFTPRKLKLGKLGMSLIGHLRDRKLF SLFLIGFLLLGSNVALFNYIVYVLLGPPYSLNKAFSSWIFIVMIVGIFSSSFIGRMVD RYGYPKILVMNIFIVIAGALFTINNMLAVKILGIALFTFGFFGGHSVASSWVGRRALH NKAQASSLYLFFYYAGSSVFGTIGGLFWSGFHWLGVVGMITFMLLVALWLSGYLARSV KMPDKRNEKGLN*" gene complement(3999670..4000884) /gene="yybF" /locus_tag="BSU_40660" /old_locus_tag="BSU40660" downshifts complement(3999688) /Source="Nicolas_upshifts" /id="D2113" /incds=0 /nref=45 /ntot=169 /MaxReadThrough="1.92237" /MaxDrop="5.70619" /score="10.1219981" /energy="-6.3" /TU="NA" /idTUdmin="U3209" /TUdmin="-20" /isTUend="TRUE" S_feature complement(4000885..4000988) /Source="Nicolas_S_feature" /locus_tag="new_4180378_4180481_c" /HighExp="BI, B60, ferm, T0.30H, T-1.10H, T-0.40H, T-1.40H, T1.0H, nit, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.94819299999999995" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1568" promotor_-10 complement(4000981..4001000) /Source="Nicolas_upshift_promotors" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 4000989..4000996 /Source="Nicolas_upshift_promotors" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(4000991) /Source="Nicolas_upshifts" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" promotor_-10 4001010..4001029 /Source="Nicolas_upshift_promotors" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(4001014..4001021) /Source="Nicolas_upshift_promotors" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 4001022 /Source="Nicolas_upshifts" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" CDS 4001071..4001949 /gene="yybE" /locus_tag="BSU_40670" /old_locus_tag="BSU40670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12169591, 17526699, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391947.2" /db_xref="EnsemblGenomes-Gn:BSU40670" /db_xref="EnsemblGenomes-Tr:CAB16104" /db_xref="GOA:P37499" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10026" /db_xref="UniProtKB/Swiss-Prot:P37499" /translation="MEWEQLEYFQTLARMQHVTKAAKSLSITQPALSRSIARLENHLG VPLFDRQGRSISLNQYGHIFLRRVQAMMKEYTEGKEEIQALLKPDQGVVSLGFLHTLG TTLVPDLIGSFQQEYPNISFQLKQNHSYWLLERLKSGDLDLCLLASIKPENPIQWIKL WSEELFVFVPNDHPLASRESITLNEIAGERFILLKKGYALRMTVDELFEKANIQPNIM FEGEEATTAAGFVAAGLGISILPDLKGLDQSKITKIRVSWPECQRVIGIAWIKGRFLS PVAETFKQYVISHFSE*" gene 4001071..4001949 /gene="yybE" /locus_tag="BSU_40670" /old_locus_tag="BSU40670" CDS 4001963..4002406 /gene="yybD" /locus_tag="BSU_40680" /old_locus_tag="BSU40680" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_391948.1" /db_xref="EnsemblGenomes-Gn:BSU40680" /db_xref="EnsemblGenomes-Tr:CAB16105" /db_xref="GOA:P37500" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10027" /db_xref="UniProtKB/Swiss-Prot:P37500" /translation="MNVKKITSEQDLHTAFEIRKAVFVEEQGCPISDEFDEFDTLHGD CQHILAYHQNVPVGTARVRIVGHTGKLERICILKSYRKFGLGKVIVDALERIVKEQGI SAFKLHGQTQAAGFYEKLGYRTASEEFMLDGIPHVLMTKQDDSAL*" gene 4001963..4002406 /gene="yybD" /locus_tag="BSU_40680" /old_locus_tag="BSU40680" CDS 4002489..4002968 /gene="yybC" /locus_tag="BSU_40690" /old_locus_tag="BSU40690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 28032445; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391949.1" /db_xref="EnsemblGenomes-Gn:BSU40690" /db_xref="EnsemblGenomes-Tr:CAB16106" /db_xref="SubtiList:BG10028" /db_xref="UniProtKB/Swiss-Prot:P37501" /translation="MPANKKEGLIFGVMMCFGMVCVMSIYNAIINRAIYDFSLMTVFE MVIGFMIALLLDLLLVGPLAKKIAFRMPFDKTKKIYVILAMSTCMVIGMVLCMSVFGL VTAVLANGLNGDSLFSAYLMIVLKNFILAYPLQLLIMGPLVRGVFMKFVKPKLTAAI* " gene 4002489..4002968 /gene="yybC" /locus_tag="BSU_40690" /old_locus_tag="BSU40690" downshifts 4002958 /Source="Nicolas_upshifts" /id="D2114" /incds=0 /nref=13 /ntot=97 /MaxReadThrough="0.69144" /MaxDrop="3.55998" /score="-9.53342462" /energy="-10.9" /TU="NA" /idTUdmin="U3210" /TUdmin=1628 /isTUend="FALSE" CDS complement(4003143..4003805) /gene="yybB" /locus_tag="BSU_40700" /old_locus_tag="BSU40700" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391950.1" /db_xref="EnsemblGenomes-Gn:BSU40700" /db_xref="EnsemblGenomes-Tr:CAB16107" /db_xref="GOA:P37502" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG10029" /db_xref="UniProtKB/Swiss-Prot:P37502" /translation="MNLRQLSEHVFQCEFELDVPLRIPVHTWFIKDGDDVYIVDTGIE RFADAQIRAALAIGNPKAILLTHGHSDHIGGASKWLERFDIPIFAHQKELKYINGEEP YPNKNEVENTGVAHIVQPLTEQTLAHLPLKYYLTPGHSPGHVVYYHKIDRTLLTGDLF ITSKEDLHPPIRRFSVDINENIDSGSIIDQIKPTLICSSHGEEILYNEELYKNYVVRY RD*" gene complement(4003143..4003805) /gene="yybB" /locus_tag="BSU_40700" /old_locus_tag="BSU40700" CDS complement(4003952..4004404) /gene="yybA" /locus_tag="BSU_40710" /old_locus_tag="BSU40710" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family, polyamine export and degradation)" /protein_id="NP_391951.1" /db_xref="EnsemblGenomes-Gn:BSU40710" /db_xref="EnsemblGenomes-Tr:CAB16108" /db_xref="GOA:P37503" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10030" /db_xref="UniProtKB/Swiss-Prot:P37503" /translation="MNDILREIGMIARALDSISNIEFKDLDLTRGQYLYLVRIYENPG IIQEKLAEMIKVDRTTAARAIKKLEMQGFIQKLPDEQNKKIKKLFPTEKGKKVYPLLR REGEHSTEVALSGFTSEEKETISALLHRVRKNIERDWEYVKKGNKRDY*" gene complement(4003952..4004404) /gene="yybA" /locus_tag="BSU_40710" /old_locus_tag="BSU40710" promotor_-35 4004428..4004435 /Source="Nicolas_upshift_promotors" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 4004450..4004469 /Source="Nicolas_upshift_promotors" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 4004452 /Source="Nicolas_upshifts" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" S_feature 4004454..4004523 /Source="Nicolas_S_feature" /locus_tag="new_4183947_4184016" /HighExp="G135, G180, H2O2, LoTm, G150, Salt, Diami, Paraq, LBGstat, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1569" promotor_-10 complement(4004457..4004476) /Source="Nicolas_upshift_promotors" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(4004459) /Source="Nicolas_upshifts" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" promotor_-35 complement(4004489..4004496) /Source="Nicolas_upshift_promotors" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 4004524..4004970 /gene="yyaT" /locus_tag="BSU_40720" /old_locus_tag="BSU40720" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase (polyamine degradation)" /protein_id="NP_391952.1" /db_xref="EnsemblGenomes-Gn:BSU40720" /db_xref="EnsemblGenomes-Tr:CAB16109" /db_xref="GOA:P37504" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10031" /db_xref="UniProtKB/Swiss-Prot:P37504" /translation="MNIKRITTEADLHEALKIRRGVFIEEQHVSEADEFDEFDTLQEQ CQHILVYHENQPVGTGRARIVGHTAKLERICILKPYRKYGLGKIIVSGLEEIMKEKGL TSYKLHGQTQAAGFYQKLGYQISSQEFMEDGIPHVLMTKEISRNIT*" gene 4004524..4004970 /gene="yyaT" /locus_tag="BSU_40720" /old_locus_tag="BSU40720" CDS 4004967..4005572 /gene="yyaS" /locus_tag="BSU_40730" /old_locus_tag="BSU40730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23504016; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391953.1" /db_xref="EnsemblGenomes-Gn:BSU40730" /db_xref="EnsemblGenomes-Tr:CAB16110" /db_xref="SubtiList:BG10032" /db_xref="UniProtKB/Swiss-Prot:P37505" /translation="MKYMYYGIGILILSLGISLTIQSGLGTSPFDALLVGLSKKIGLT VGSWEVLISVILLICNAILTRKKPILLGLITAFITGIGIDLWLFVVKNTIYLNSLLSK LICFGIGLVLIGLGTAIYLQTKFASTPIDHLTLIIRDLSKRTILFSRTLVYALFLVLA IIFKGPIGIGTLLTVCLGGMLLHVFMPIVERHFLSKNRRGY*" gene 4004967..4005572 /gene="yyaS" /locus_tag="BSU_40730" /old_locus_tag="BSU40730" CDS complement(4005667..4006188) /gene="yyaR" /locus_tag="BSU_40740" /old_locus_tag="BSU40740" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16579456, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyl-transferase" /protein_id="NP_391954.1" /db_xref="EnsemblGenomes-Gn:BSU40740" /db_xref="EnsemblGenomes-Tr:CAB16111" /db_xref="GOA:P37506" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR008125" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10033" /db_xref="UniProtKB/Swiss-Prot:P37506" /translation="MIMKMTHLNMKDFNKPNEPFVVFGRMIPAFENGVWTYTEERFSK PYFKQYEDDDMDVSYVEEEGKAAFLYYLENNCIGRIKIRSNWNGYALIEDIAVAKDYR KKGVGTALLHKAIEWAKENHFCGLMLETQDINISACHFYAKHHFIIGAVDTMLYSNFP TANEIAIFWYYKF*" gene complement(4005667..4006188) /gene="yyaR" /locus_tag="BSU_40740" /old_locus_tag="BSU40740" S_feature complement(4006189..4007016) /Source="Nicolas_S_feature" /locus_tag="new_4185682_4186509_c" /HighExp="T0.30H, Lbstat, H2O2, LPhT, T1.0H, dia15, Diami, T1.30H, dia5, M9-stat" /AntisenseName="yyaQ" /AntisenseCor="0.51412050904654805" /AntisenseRegPval="-18.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1570" promotor_-35 4006237..4006244 /Source="Nicolas_upshift_promotors" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 4006258 /Source="Nicolas_upshifts" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 4006259..4006278 /Source="Nicolas_upshift_promotors" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 4006324..4006598 /Source="Nicolas_S_feature" /locus_tag="new_4185817_4186091" /HighExp="LBGstat, G135, BC, G180, Sw, M9-stat, Diami, T0.30H, H2O2, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.13713" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1571" upshifts 4006324 /Source="Nicolas_upshifts" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" promotor_-35 4006327..4006332 /Source="Nicolas_upshift_promotors" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 4006345..4006364 /Source="Nicolas_upshift_promotors" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 4006599..4006955 /gene="yyaQ" /locus_tag="BSU_40750" /old_locus_tag="BSU40750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391955.1" /db_xref="EnsemblGenomes-Gn:BSU40750" /db_xref="EnsemblGenomes-Tr:CAB16112" /db_xref="InterPro:IPR007351" /db_xref="SubtiList:BG10034" /db_xref="UniProtKB/Swiss-Prot:P37507" /translation="MLTREDIFKHVKEKYGTSPDYPWEKYPNYASLRHTSNKKWYGLI MNVLPEKLGLDGHGEIDILNLKCPPEISDRLRNGENILPGYHMDKEHWISIVLERTDP EGEIYNLIEQSFHLTK*" gene 4006599..4006955 /gene="yyaQ" /locus_tag="BSU_40750" /old_locus_tag="BSU40750" S_feature 4006956..4007114 /Source="Nicolas_S_feature" /locus_tag="new_4186449_4186607" /HighExp="Sw, BC, G135, H2O2, LBGstat, G180, LPhT, T0.30H, Diami, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1572" promotor_-10 complement(4006998..4007017) /Source="Nicolas_upshift_promotors" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(4007016) /Source="Nicolas_upshifts" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" promotor_-35 complement(4007032..4007039) /Source="Nicolas_upshift_promotors" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" /label="promotor_-35" CDS 4007115..4007681 /gene="yyaP" /locus_tag="BSU_40760" /old_locus_tag="BSU40760" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391956.1" /db_xref="EnsemblGenomes-Gn:BSU40760" /db_xref="EnsemblGenomes-Tr:CAB16113" /db_xref="GOA:P37508" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR024072" /db_xref="PDB:2GD9" /db_xref="SubtiList:BG10035" /db_xref="UniProtKB/Swiss-Prot:P37508" /translation="MTNNLKQRRIILDLAVTLDGFIEGKNGEVDWCIMDPDMGFTDFL NQIDTILYGRKSFDLWGQYIPKNEDPDTEKELWKLVHSKKKYVFSRTQNEIDNQAIFI NDNILEEVNKLKKNPGKDIWLYGGASLITTFINLGLVDEFRLSIHPVVLGEGKPLFID VKQRINLKMVNTRTFSSGVVQIVYHWNG*" gene 4007115..4007681 /gene="yyaP" /locus_tag="BSU_40760" /old_locus_tag="BSU40760" CDS complement(4008188..4009564) /gene="tetB" /locus_tag="BSU_40770" /old_locus_tag="BSU40770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7961647, 14636065, 15849754, 16850406, 17015648, 25954268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7961647, 14636065, 15849754, 16850406, 17015648, 25954268; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multifunctional tetracycline-metal/H+ antiporterand Na+(K+)/H+ antiporter" /protein_id="NP_391957.1" /db_xref="EnsemblGenomes-Gn:BSU40770" /db_xref="EnsemblGenomes-Tr:CAB16114" /db_xref="GOA:P23054" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10036" /db_xref="UniProtKB/Swiss-Prot:P23054" /translation="MNTSYSQSTLRHNQVLIWLCVLSFFSVLNEMVLNVSLPDIANEF NKLPASANWVNTAFMLTFSIGTALYGKLSDQLGIKNLLLFGIMVNGLGSIIGFVGHSF FPILILARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGG MVAHYIHWSYLLLIPTATIITVPFLIKLLKKEERIRGHIDMAGIILMSAGIVFFMLFT TSYRFSFLIISILAFFIFVQHIRKAQDPFVDPELGKNVFFVIGTLCGGLIFGTVAGFV SMVPYMMKDVHHLSTAAIGSGIIFPGTMSVIIFGYIGGLLVDRKGSLYVLTIGSALLS SGFLIAAFFIDAAPWIMTIIVIFVFGGLSFTKTVISTVVSSSLKEKEAGAGMSLLNFT SFLSEGTGIAIVGGLLSIGFLDHRLLPIDVDHSTYLYSNMLILFAGIIVICWLVILNV YKRSRRHG*" gene complement(4008188..4009564) /gene="tetB" /locus_tag="BSU_40770" /old_locus_tag="BSU40770" CDS complement(4009598..4009660) /gene="tetL" /locus_tag="BSU_40780" /old_locus_tag="BSU40780" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14636065, 17015648" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14636065, 17015648; Product type t: transporter" /codon_start=1 /transl_table=11 /product="tetracycline resistance leader peptide" /protein_id="NP_391958.1" /db_xref="EnsemblGenomes-Gn:BSU40780" /db_xref="EnsemblGenomes-Tr:CAB16115" /db_xref="GOA:P23053" /db_xref="InterPro:IPR012618" /db_xref="SubtiList:BG11051" /db_xref="UniProtKB/Swiss-Prot:P23053" /translation="MKCNKMNRVQLKEGSVSMTL*" gene complement(4009598..4009660) /gene="tetL" /locus_tag="BSU_40780" /old_locus_tag="BSU40780" promotor_-10 complement(4009681..4009700) /Source="Nicolas_upshift_promotors" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(4009700) /Source="Nicolas_upshifts" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" promotor_-35 complement(4009713..4009720) /Source="Nicolas_upshift_promotors" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 4009848..4009854 /Source="Nicolas_upshift_promotors" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 4009870..4009889 /Source="Nicolas_upshift_promotors" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 4009876 /Source="Nicolas_upshifts" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" CDS 4009913..4010152 /gene="yyaO" /locus_tag="BSU_40790" /old_locus_tag="BSU40790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391959.1" /db_xref="EnsemblGenomes-Gn:BSU40790" /db_xref="EnsemblGenomes-Tr:CAB16116" /db_xref="InterPro:IPR004879" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10037" /db_xref="UniProtKB/Swiss-Prot:P37509" /translation="MPNKSKPNRLIAEKSPYLLQHAHNPVDWFPWGEEAFAKAKRENK PVLVSIGYSTTCHWWPGIIKSCGTPLKDNRSHFKR*" gene 4009913..4010152 /gene="yyaO" /locus_tag="BSU_40790" /old_locus_tag="BSU40790" downshifts 4010161 /Source="Nicolas_upshifts" /id="D2115" /incds=0 /nref=7 /ntot=103 /MaxReadThrough="1.03879" /MaxDrop="3.89186" /score="10.758481" /energy="-8.2" /TU="NA" /idTUdmin="U3217" /TUdmin=9 /isTUend="TRUE" promotor_-35 4010245..4010252 /Source="Nicolas_upshift_promotors" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 4010268..4010287 /Source="Nicolas_upshift_promotors" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 4010284 /Source="Nicolas_upshifts" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" CDS 4010303..4010719 /gene="yyaN" /locus_tag="BSU_40800" /old_locus_tag="BSU40800" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11948146, 14663075; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MerR family)" /protein_id="NP_391960.1" /db_xref="EnsemblGenomes-Gn:BSU40800" /db_xref="EnsemblGenomes-Tr:CAB16117" /db_xref="GOA:P37510" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG10038" /db_xref="UniProtKB/Swiss-Prot:P37510" /translation="MLLYSISKAAEKTSISSYTLRYYEKIGLLPPPKRKNSGRRFYTE TDIQFMLFLKSLKETGMSLEDINEFVKDGCILEKINSDVKSAQLSPSINKRIEILTKH LEKMEIKKRELEEVISTTKGKLDTYYSILKEEVENK*" gene 4010303..4010719 /gene="yyaN" /locus_tag="BSU_40800" /old_locus_tag="BSU40800" CDS 4010716..4011633 /gene="yyaM" /locus_tag="BSU_40810" /old_locus_tag="BSU40810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391961.1" /db_xref="EnsemblGenomes-Gn:BSU40810" /db_xref="EnsemblGenomes-Tr:CAB16118" /db_xref="GOA:P37511" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10039" /db_xref="UniProtKB/Swiss-Prot:P37511" /translation="MKHLNIYIMLLGFSIFTGATFNLAKYTVGYFSPSSSAAWRFGLA AAVMLIILIFTEGIKKSQLRKNAVSYIVLGIIGIFGFNALFFVGLKYTSPVNGALIMG LNPLLTAILARIILKDNMTKKQVLGIFFAFIGVLLVITQGSIETIKTLSISGGDLIIF TGNVCWALYGVLGRRFVKDGTPLSTTTYTMVIGAVSLIVVSLFTSKPVSLSNIPIGVW GAIAFMAFFTSVLGYLWWNQGIKEIGASKTSLFFNLVPVVTMIISFAVGTPIKVFQVI GAVLVILGVLTASGVIRIPKYNTKEQSAI*" gene 4010716..4011633 /gene="yyaM" /locus_tag="BSU_40810" /old_locus_tag="BSU40810" misc_feature 4011660..4011679 /Source="Nicolas_upshift_promotors" /id="U3219" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig="0.984015984015984" /xcortree=1462 /SigmaFactorBS="actaaagaacagtcagctatataaagaaatagggagtatttt tgagaaaaTGTGTTAAGTTAAATATACActaattataggaagaaggtgatcccatgcc a" /listShort="yyaL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 4011670 /Source="Nicolas_upshifts" /id="U3219" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig="0.984015984015984" /xcortree=1462 /SigmaFactorBS="actaaagaacagtcagctatataaagaaatagggagtatttt tgagaaaaTGTGTTAAGTTAAATATACActaattataggaagaaggtgatcccatgcc a" /listShort="yyaL" /GFF_Attribute="listLong" promotor_-10 complement(4011674..4011693) /Source="Nicolas_upshift_promotors" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(4011680) /Source="Nicolas_upshifts" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 4011705..4013774 /gene="yyaL" /locus_tag="BSU_40820" /old_locus_tag="BSU40820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391962.1" /db_xref="EnsemblGenomes-Gn:BSU40820" /db_xref="EnsemblGenomes-Tr:CAB16119" /db_xref="GOA:P37512" /db_xref="InterPro:IPR004879" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR024705" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10040" /db_xref="UniProtKB/Swiss-Prot:P37512" /translation="MPNKSKPNRLINEKSPYLLQHAHNPVDWFPWGEEAFEKAKRENK PVLVSIGYSTCHWCHVMAHESFEDEEIARLLNERFVAIKVDREERPDVDSVYMRICQL MTGQGGWPLNVFITPDQKPFYAGTYFPKTSKFNRPGFVDVLEHLSETFANDREHVEDI AENAAKHLQTKTAAKTGEGLSESAIHRTFQQLASGFDTIYGGFGQAPKFPMPHMLMYL LRYDHNTGQENALYNVTKTLDSMANGGIYDHIGYGFARYSTDDEWLVPHFEKMLYDNA LLLTAYTEAYQVTQNSRYKEICEQIITFIQREMTHEDGSFFSALDADTEGEEGKYYVW SKEEILKTLGDDLGTLYCQVYDITEEGNFEGKNIPNLIHTKREQIKEDAGLTEKELSL KLEDARQQLLKTREERTYPHVDDKVLTSWNALMIAGLAKAAKVYQEPKYLSLAKDAIT FIENKLIIDGRVMVRYRDGEVKNKGFIDDYAFLLWAYLDLYEASFDLSYLQKAKKLTD DMISLFWDEEHGGFYFTGHDAEALIVREKEVYDGAVPSGNSVAAVQLLRLGQVTGDLS LIEKAETMFSVFKPDIEAYPSGHAFFMQSVLRHLMPKKEIVIFGSADDPARKQIIAEL QKAFKPNDSILVAEQPEQCKDIAPFAADYRIIDGKTTVYICENFACQQPTTNIEEAIH TLISSRD*" gene 4011705..4013774 /gene="yyaL" /locus_tag="BSU_40820" /old_locus_tag="BSU40820" promotor_-35 complement(4011707..4011714) /Source="Nicolas_upshift_promotors" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 4013738 /Source="Nicolas_upshifts" /id="D2116" /incds=0 /nref=221 /ntot=260 /MaxReadThrough="1.24617" /MaxDrop="5.71843" /score="11.6894527" /energy="-16.6" /TU="NA" /idTUdmin="U3219" /TUdmin=0 /isTUend="TRUE" CDS complement(4013771..4014670) /gene="yyaK" /locus_tag="BSU_40830" /old_locus_tag="BSU40830" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11343912, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protease" /protein_id="NP_391963.1" /db_xref="EnsemblGenomes-Gn:BSU40830" /db_xref="EnsemblGenomes-Tr:CAB16120" /db_xref="GOA:P37513" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG10041" /db_xref="UniProtKB/Swiss-Prot:P37513" /translation="MNSFIRPIEGNNTLWRYFFAFLVMVGLYVLGNIAYLFAILFTVI VNPNITFDLDEAVLSDPLVDLYLSHVIYLFAIPGVWLAVRFILKRPFRTVITPNSKMN WRRISFGFIAYFLLMIAVQLIDFVIHPDSYSMQEFNASRFIWLLAAALILVPIQTSAE ELFFRGFLLQAFGRLTKNPLFLTLIVGGLFGVLHFANPEMNNGAVWAGIEYLTFGFVW TYYTIKTGSIEISLGAHAANNMFLCMFITEKNSVYGGIPSLFTVTRGNPMWEAFFTIA VNLVFAGIALWYHKKSKSKQQGS*" gene complement(4013771..4014670) /gene="yyaK" /locus_tag="BSU_40830" /old_locus_tag="BSU40830" downshifts complement(4013814) /Source="Nicolas_upshifts" /id="D2117" /incds=0 /nref=65 /ntot=246 /MaxReadThrough="2.6155" /MaxDrop="3.91098" /score="23.2445146" /energy="-14.7" /TU="NA" /idTUdmin="U3221" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(4014699..4014718) /Source="Nicolas_upshift_promotors" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(4014715) /Source="Nicolas_upshifts" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" S_feature complement(4014717..4015948) /Source="Nicolas_S_feature" /locus_tag="new_4194210_4195441_c" /HighExp="S6, S8, S7, S5, B36, BT, S4, B60, S3, Diami" /AntisenseName="yyaJ" /AntisenseCor="-0.24400480530035801" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1573" promotor_-35 complement(4014733..4014740) /Source="Nicolas_upshift_promotors" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 4014811..4014818 /Source="Nicolas_upshift_promotors" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 4014832..4014851 /Source="Nicolas_upshift_promotors" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 4014838 /Source="Nicolas_upshifts" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" CDS 4014896..4016251 /gene="yyaJ" /locus_tag="BSU_40840" /old_locus_tag="BSU40840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 9529885, 19087206, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391964.2" /db_xref="EnsemblGenomes-Gn:BSU40840" /db_xref="EnsemblGenomes-Tr:CAB16121" /db_xref="GOA:P37514" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10042" /db_xref="UniProtKB/Swiss-Prot:P37514" /translation="MNTIFKQKNTHPFSNAANRLDRLPISRVHFQVLTALGIVYFFDL ADLFTLSNVAPALIEHWGIPLSTIANVTAASFLGMFLGASLGGRLSDRIGRKKALNLF VFVFSIASLCNAAAWDIPSLMTFRFLTGFGVAAAMVITNSYLAEFFPSSVRGKYISFC AMIGLIGVPITNIVSAFVIPLGSWGWRLVFVWGAVGLIYFFFIHRLEESPRWHENRGE YAKADAILTRIEEQVEKEKGPLPAASQPKVSETVKQNAGYAGLLKGRNLKITIVLSAV WIFETFGFYGFASWVPSLLKSNGVTMENTLWYNVLHSVGAPLGALLGSMISERFQRKW ILAASAFLTAIAGLLYGMTFIPIMIIVFGFIVNITERVFTSNLYAYTSEPYPTEYRSS GSGLAYGLGRFSNIFGSLLVGFIAVQLGYISVFLFIGGCWLACSLLLIFFGPNTNAKQ I*" gene 4014896..4016251 /gene="yyaJ" /locus_tag="BSU_40840" /old_locus_tag="BSU40840" promotor_-10 complement(4015934..4015953) /Source="Nicolas_upshift_promotors" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(4015958) /Source="Nicolas_upshifts" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" promotor_-35 complement(4015967..4015976) /Source="Nicolas_upshift_promotors" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(4016285..4016839) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" /EC_number="2.3.1.79" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12731863, 12793527, 19087206, 22226636, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose O-acetyltransferase" /protein_id="NP_391965.1" /db_xref="EnsemblGenomes-Gn:BSU40850" /db_xref="EnsemblGenomes-Tr:CAB16122" /db_xref="GOA:P37515" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR024688" /db_xref="SubtiList:BG10043" /db_xref="UniProtKB/Swiss-Prot:P37515" /translation="MLRTEKEKMAAGELYNSEDQQLLLERKHARQLIRQYNETPEDDA VRTKLLKELLGSVGDQVTILPTFRCDYGYHIHIGDHTFVNFDCVILDVCEVRIGCHCL IAPGVHIYTAGHPLDPIERKSGKEFGKPVTIGDQVWIGGRAVINPGVTIGDNAVIASG SVVTKDVPANTVVGGNPARILKQL*" gene complement(4016285..4016839) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" CDS complement(4016857..4017237) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19087206; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_391966.1" /db_xref="EnsemblGenomes-Gn:BSU40860" /db_xref="EnsemblGenomes-Tr:CAB16123" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10044" /db_xref="UniProtKB/Swiss-Prot:P37516" /translation="MQIEHTAVWVNDLERMKSFYESYFNGEANDLYHNEKKDFKSYFI TFDSGARLEIMKKGNVTDPPSQTMTGWAHIAFSVGSREKVDELTDRLKADGFAVVNGP RTTGDGYYESVIEDDEGNLIEITI*" gene complement(4016857..4017237) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" CDS complement(4017293..4018228) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9457849, 9642180, 16267306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9457849, 9642180, 16267306; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of carbon supply (LacIfamily)" /protein_id="NP_391967.1" /db_xref="EnsemblGenomes-Gn:BSU40870" /db_xref="EnsemblGenomes-Tr:CAB16124" /db_xref="GOA:P37517" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10045" /db_xref="UniProtKB/Swiss-Prot:P37517" /translation="MANIKEIARLANVSVSTVSRVLNHHPYVSEEKRKLVHQVMKELD YTPNRTAIDLIRGKTHTVGVILPYSDHPCFDKIVNGITKAAFQHEYATTLLPTNYNPD IEIKYLELLRTKKIDGLIITSRANHWDSILAYQEYGPVIACEDTGDIDVPCAFNDRKT AYAESFRYLKSRGHENIAFTCVREADRSPSTADKAAAYKAVCGRLEDRHMLSGCNDMN DGELAAEHFYMSGRVPTAIYANSDEVAAGIHLFAKKNNWDVEIIGEGNTSISRVLGFP SLDLNLEQLGIAAFSLFLQDEPADIKIQHKFKKKA*" gene complement(4017293..4018228) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" promotor_-35 4018218..4018227 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 4018241..4018260 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 4018248 /Source="Nicolas_upshifts" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(4018272..4018291) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(4018286) /Source="Nicolas_upshifts" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" CDS complement(4018287..4019045) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" /EC_number="3.1.11.2" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10540738, 16237020, 18203828, 21441501, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10540738, 16237020, 18203828, 21441501, 24244006, 24914186; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="apurinic/apyrimidinic endonuclease" /protein_id="NP_391968.1" /db_xref="EnsemblGenomes-Gn:BSU40880" /db_xref="EnsemblGenomes-Tr:CAB16125" /db_xref="GOA:P37454" /db_xref="InterPro:IPR004808" /db_xref="InterPro:IPR005135" /db_xref="InterPro:IPR020847" /db_xref="InterPro:IPR020848" /db_xref="InterPro:IPR036691" /db_xref="PDB:5CFE" /db_xref="SubtiList:BG10046" /db_xref="UniProtKB/Swiss-Prot:P37454" /translation="MKLISWNVNGLRAVMRKMDFLSYLKEEDADIICLQETKIQDGQV DLQPEDYHVYWNYAVKKGYSGTAVFSKQEPLQVIYGIGVEEHDQEGRVITLEFENVFV MTVYTPNSRRGLERIDYRMQWEEALLSYILELDQKKPVILCGDLNVAHQEIDLKNPKA NRNNAGFSDQEREAFTRFLEAGFVDSFRHVYPDLEGAYSWWSYRAGARDRNIGWRIDY FVVSESLKEQIEDASISADVMGSDHCPVELIINI*" gene complement(4018287..4019045) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" promotor_-35 complement(4018304..4018311) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 4018578..4019081 /Source="Nicolas_S_feature" /locus_tag="new_4198071_4198574" /HighExp="C30, S8, S7, S6, BT, S5, M/G, Glucon, C90, T1.0H" /AntisenseName="exoAA" /AntisenseCor="-0.177921457862244" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1574" downshifts 4019040 /Source="Nicolas_upshifts" /id="D2118" /incds=0 /nref=2 /ntot=12 /MaxReadThrough="2.65789" /MaxDrop="4.11352" /score="16.4680636" /energy="-6.8" /TU="NA" /idTUdmin="U3224" /TUdmin=528 /isTUend="FALSE" CDS complement(4019110..4019349) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 22720735, 24310371" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 22720735, 24310371; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S18" /protein_id="NP_391969.2" /db_xref="EnsemblGenomes-Gn:BSU40890" /db_xref="EnsemblGenomes-Tr:CAB16126" /db_xref="GOA:P21475" /db_xref="InterPro:IPR001648" /db_xref="InterPro:IPR018275" /db_xref="InterPro:IPR036870" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10047" /db_xref="UniProtKB/Swiss-Prot:P21475" /translation="MAGGRRGGRAKRRKVCYFTSNGITHIDYKDVDLLKKFVSERGKI LPRRVTGTNAKYQRKLTAAIKRARQMALLPYVSGE*" gene complement(4019110..4019349) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" downshifts complement(4019116) /Source="Nicolas_upshifts" /id="D2119" /incds=0 /nref=217 /ntot=268 /MaxReadThrough="4.97781" /MaxDrop="7.46952" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227" /idTUdmin="U3229" /TUdmin=0 /isTUend="TRUE" downshifts complement(4019184) /Source="Nicolas_upshifts" /id="D2120" /incds=1 /nref=13 /ntot=142 /MaxReadThrough="8.89363" /MaxDrop="3.9797" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227,U3229" /idTUdmin="U3229" /TUdmin="-68" /isTUend="FALSE" CDS complement(4019393..4019911) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391970.1" /db_xref="EnsemblGenomes-Gn:BSU40900" /db_xref="EnsemblGenomes-Tr:CAB16127" /db_xref="GOA:P37455" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10048" /db_xref="UniProtKB/Swiss-Prot:P37455" /translation="MLNRVVLVGRLTKDPELRYTPNGAAVATFTLAVNRTFTNQSGER EADFINCVTWRRQAENVANFLKKGSLAGVDGRLQTRNYENQQGQRVFVTEVQAESVQF LEPKNGGGSGSGGYNEGNSGGGQYFGGGQNDNPFGGNQNNQRRNQGNSFNDDPFANDG KPIDISDDDLPF*" gene complement(4019393..4019911) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" CDS complement(4019952..4020239) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 19653700, 26447183" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 19653700, 26447183; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S6 (BS9)" /protein_id="NP_391971.1" /db_xref="EnsemblGenomes-Gn:BSU40910" /db_xref="EnsemblGenomes-Tr:CAB16128" /db_xref="GOA:P21468" /db_xref="InterPro:IPR000529" /db_xref="InterPro:IPR014717" /db_xref="InterPro:IPR020814" /db_xref="InterPro:IPR020815" /db_xref="InterPro:IPR035980" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10049" /db_xref="UniProtKB/Swiss-Prot:P21468" /translation="MRKYEVMYIIRPNIDEESKKAVIERFNNVLTSNGAEITGTKDWG KRRLAYEINDFRDGFYQIVNVQSDAAAVQEFDRLAKISDDIIRHIVVKEEE*" gene complement(4019952..4020239) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" S_feature complement(4020240..4020306) /Source="Nicolas_S_feature" /locus_tag="new_4199733_4199799_c" /HighExp="MG t5, LPhT, GM 90, SMM, T-5.40H, GM-0.2, MG 150, GM 45, Gly, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.993, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1575" promotor_-10 complement(4020305..4020324) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(4020306) /Source="Nicolas_upshifts" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" promotor_-35 complement(4020338..4020343) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(4020350..4021450) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12837776, 16014871, 18713637, 21527254, 22995830, 26018081, 26160547, 26912459; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent informational ATPase interacting with 70S ribosome; ROS stress regulator" /protein_id="NP_391972.1" /db_xref="EnsemblGenomes-Gn:BSU40920" /db_xref="EnsemblGenomes-Tr:CAB16129" /db_xref="GOA:P37518" /db_xref="InterPro:IPR004396" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR013029" /db_xref="InterPro:IPR023192" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="SubtiList:BG10050" /db_xref="UniProtKB/Swiss-Prot:P37518" /translation="MALTAGIVGLPNVGKSTLFNAITQAGAESANYPFCTIDPNVGIV EVPDDRLQKLTELVNPKKTVPTAFEFTDIAGIVKGASKGEGLGNKFLSHIRQVDAICH VVRAFSDDNITHVSGKVDPIDDIETINLELILADMETVEKRITRVSKLAKQKDKDAVF EFEILSKLKEAFESEKPARSVEFTEEQQKLVKQLHLLTSKPILYVANVSEDEVADPSG NENVAKIREYAAGENAEVIVVCAKIESEIAELEGEEKQMFLEELGIQESGLDQLIKAS YSLLGLATYFTAGEQEVRAWTFKKGMKAPECAGIIHSDFERGFIRAETVAYEDLLAGG GMAGAKEAGKVRLEGKEYVVQDGDVIHFRFNV*" gene complement(4020350..4021450) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" promotor_-10 complement(4021498..4021517) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-10" upshifts complement(4021513) /Source="Nicolas_upshifts" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" promotor_-35 complement(4021532..4021539) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-35" CDS complement(4021577..4023580) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" /EC_number="1.-.-.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17114254, 20817769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (molybdoenzyme)" /protein_id="NP_391973.1" /db_xref="EnsemblGenomes-Gn:BSU40930" /db_xref="EnsemblGenomes-Tr:CAB16130" /db_xref="GOA:P37519" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG10051" /db_xref="UniProtKB/Swiss-Prot:P37519" /translation="MSKVHQSACPLNCWDSCGFLVTVDDGKVTKVDGDPNHPITEGKI CGRGRMLETKTNSPDRLRYPMKKQNGEFVRISWEQALDEIADKLREIKETSETTAVLH SHDYANNGLLKALDQRFFNGYGGVTEIVGSICWGSGIEAQSWDFGRSYGHGPLDIYNS KHVVVWGRNVSRTNMHLYHHLQQVKKKGATITVIDPIFNPTAKLADRYISVKPGMDGW LAAAVLKVLIEMGRTDETFISEHSVGFDDVKELLKTVSLEEFIVKTETSMEELEYLAG LYADGPVSTFMGLGMQRYKNGGGTIRWIDALVAASGNVGIKGGGANFGNVQIGESFAK TKLTLPELKTTSRSFSMMTQAEEVLTAADPAIEMIIVTCGNPLTQVPNTNKVRQAFEK VPMTVAIDSIMTDTAELCDYVLPTATVFEEEDIYYSSMYHHYVQYGKKLVEPQGEAKS DSWIWSELAKRLGFGELFEYSTQEFLEMGLSSLEAEDVTLERLKEKGHLPLPVKQVPW DDYQFLTPSGKFEFTSSLAEQKGFSGSLQLNVPEESVFHNEELAGKYPYTLLSIHPQR SNHSQHVPFIEKLQHVQVDISPDIAAGQDLQDGDEVVIFNDRGSMKGKVKVMKQAHAK TINIDEGMWAAFGGSVNALTNDTNSDNGMGSTLFDCLVGLKKA*" gene complement(4021577..4023580) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" CDS complement(4023631..4023837) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21348639, 22333191, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="YP_003097803.1" /db_xref="EnsemblGenomes-Gn:BSU40939" /db_xref="EnsemblGenomes-Tr:CAX52723" /db_xref="InterPro:IPR009296" /db_xref="UniProtKB/Swiss-Prot:C0H3V8" /translation="MADKDFGLNDIVEMKKPHPCGANSWKIIRMGMDIRIKCEGCSHS VMIPRREFERKLKKVLVKHEEPTS*" gene complement(4023631..4023837) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" promotor_-10 complement(4023799..4023818) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(4023824) /Source="Nicolas_upshifts" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(4023833..4023839) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(4023863..4023882) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-10" upshifts complement(4023874) /Source="Nicolas_upshifts" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" promotor_-35 complement(4023899..4023903) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-35" CDS complement(4023931..4024947) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16847258, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391974.1" /db_xref="EnsemblGenomes-Gn:BSU40940" /db_xref="EnsemblGenomes-Tr:CAB16131" /db_xref="SubtiList:BG10052" /db_xref="UniProtKB/Swiss-Prot:P37520" /translation="MLWRAGMKWMLLILGSLIGAGYASGQEIWQFFGAESGLAIVLFT IMFIFSSYIVMKISFKVQSTHFLPVLEHLMGPWLAKIYDVLIIFYLFSTTMVMIAGGG VTLQMYKLPFWWGITLICIVTVCLFLWDVKGILSINSILIPVLVAGLLYALISFQSTH HHTWTIDLSQQYNWPASITFTSLNILSVVAILSSVGKEMKGLGEAKIASVASGLIFGV ISFVYNETLVELAGSLSQFEIPLFAVLEGAPYFLFLCMTAVLCLAIYTTTVAGLLGLS SRLMAFIHMPRWMIVLILLVLMVPFTSFGFSDLIAFLYPIYGMLNLYLLVCLLLYPIL SKWK*" gene complement(4023931..4024947) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" promotor_-10 complement(4024980..4024998) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(4024992) /Source="Nicolas_upshifts" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" promotor_-35 complement(4025014..4025019) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(4025123) /Source="Nicolas_upshifts" /id="D2121" /incds=0 /nref=32 /ntot=184 /MaxReadThrough="1.8976" /MaxDrop="3.72136" /score="9.09987016" /energy="-7.4" /TU="NA" /idTUdmin="U3230" /TUdmin="-397" /isTUend="FALSE" promotor_-35 4025307..4025312 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 4025325..4025406 /Source="Nicolas_S_feature" /locus_tag="new_4204818_4204899" /HighExp="S4, S5, S3, S6, LoTm, S7, T5.0H, BT, M9-stat, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1576" upshifts 4025325 /Source="Nicolas_upshifts" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" promotor_-10 4025328..4025346 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 4025407..4026024 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 26362088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore-specific protease" /protein_id="NP_391975.1" /db_xref="EnsemblGenomes-Gn:BSU40950" /db_xref="EnsemblGenomes-Tr:CAB16132" /db_xref="InterPro:IPR009665" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10053" /db_xref="UniProtKB/Swiss-Prot:P37521" /translation="MNRKGGLFSSQERVKQYVSHTDAAAAKQIQTILSSSLRKAAGKP IVVVCIGTDRSTGDSLGPLVGMKLKQMQLTRFHVYGTLSDPVHAVNMKDKINDIHKLH KNPFVIAVDACLGRVKSVGSFQIGDGPLKPGAGVQKDLPEVGDLHINGIVNVSGFMEY FVLQNTRLNLVMNMANVLAEGLSLTDRTEWRQERLNPLQRLTGRI*" gene 4025407..4026024 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" promotor_-35 4025995..4026003 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 4026014 /Source="Nicolas_upshifts" /id="D2122" /incds=0 /nref=11 /ntot=30 /MaxReadThrough="2.64888" /MaxDrop="3.74502" /score="0.352922387" /energy="-6.6" /TU="NA" /idTUdmin="U3231" /TUdmin=0 /isTUend="TRUE" promotor_-10 4026017..4026035 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 4026036 /Source="Nicolas_upshifts" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(4026063..4026911) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103; Product type f: factor" /codon_start=1 /transl_table=11 /product="site-specific DNA-binding protein" /protein_id="NP_391976.1" /db_xref="EnsemblGenomes-Gn:BSU40960" /db_xref="EnsemblGenomes-Tr:CAB16133" /db_xref="GOA:P26497" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10054" /db_xref="UniProtKB/Swiss-Prot:P26497" /translation="MAKGLGKGINALFNQVDLSEETVEEIKIADLRPNPYQPRKHFDD EALAELKESVLQHGILQPLIVRKSLKGYDIVAGERRFRAAKLAGLDTVPAIVRELSEA LMREIALLENLQREDLSPLEEAQAYDSLLKHLDLTQEQLAKRLGKSRPHIANHLRLLT LPENIQQLIAEGTLSMGHGRTLLGLKNKNKLEPLVQKVIAEQLNVRQLEQLIQQLNQN VPRETKKKEPVKDAVLKERESYLQNYFGTTVNIKRQKKKGKIEIEFFSNEDLDRILEL LSERES*" gene complement(4026063..4026911) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" downshifts complement(4026083) /Source="Nicolas_upshifts" /id="D2123" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="3.01094" /MaxDrop="5.3801" /score="9.82080496" /energy="-7.9" /TU="U3233" /idTUdmin="U3233" /TUdmin="-257" /isTUend="FALSE" CDS complement(4026904..4027665) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome partitioning protein; transcriptionalregulator" /protein_id="NP_391977.1" /db_xref="EnsemblGenomes-Gn:BSU40970" /db_xref="EnsemblGenomes-Tr:CAB16134" /db_xref="GOA:P37522" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10055" /db_xref="UniProtKB/Swiss-Prot:P37522" /translation="MGKIIAITNQKGGVGKTTTSVNLGACLAYIGKRVLLVDIDPQGN ATSGLGIEKADVEQCVYDILVDDADVIDIIKATTVENLDVIPATIQLAGAEIELVPTI SREVRLKRALEAVKQNYDYIIIDCPPSLGLLTINALTASDSVVIPVQCEYYALEGLSQ LLNTVRLVQKHLNTDLMIEGVLLTMLDARTNLGIQVIEEVKKYFRDKVYKTVIPRNVR LSEAPSHGKPIILYDPRSRGAEVYLDLAKEVAANG*" gene complement(4026904..4027665) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" misc_feature complement(4027699..4027718) /Source="Nicolas_upshift_promotors" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(4027717) /Source="Nicolas_upshifts" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" upshifts complement(4027809) /Source="Nicolas_upshifts" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" promotor_-10 complement(4027812..4027820) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-10" promotor_-35 complement(4027834..4027842) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-35" promotor_-35 4027846..4027854 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 4027862 /Source="Nicolas_upshifts" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" promotor_-10 4027866..4027884 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 4027913..4028353 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25651892; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative antibiotic immunity protein" /protein_id="NP_391978.2" /db_xref="EnsemblGenomes-Gn:BSU40980" /db_xref="EnsemblGenomes-Tr:CAB16135" /db_xref="GOA:P37523" /db_xref="InterPro:IPR009589" /db_xref="SubtiList:BG10056" /db_xref="UniProtKB/Swiss-Prot:P37523" /translation="MVYQTKRDVPVTLMIVFLILLIQADAIVPFVLGNMRVSGWIIFI LLTLLNGLIIWSFIDLKYVLKEHHLIIKAGLIKHQIPYENIDKVVQKKKLWSGFRLIG SRHAITIYYQGGWGHAVISPQKSEEFIHKLKEKNSNIIIFTKSK*" gene 4027913..4028353 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" downshifts 4028302 /Source="Nicolas_upshifts" /id="D2124" /incds=0 /nref=3 /ntot=144 /MaxReadThrough="2.25356" /MaxDrop="3.41185" /score="-0.6683508" /energy="-14.5" /TU="NA" /idTUdmin="U3235" /TUdmin=0 /isTUend="TRUE" CDS complement(4028404..4029255) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" /function="16.13: Shape" /function="16.8: Protect" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11807071, 15210112, 16549676, 25568309, 28500529" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807071, 15210112, 16549676, 25568309, 28500529; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-binding protein Spo0J-like" /protein_id="NP_391979.1" /db_xref="EnsemblGenomes-Gn:BSU40990" /db_xref="EnsemblGenomes-Tr:CAB16136" /db_xref="GOA:P37524" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR023705" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10057" /db_xref="UniProtKB/Swiss-Prot:P37524" /translation="MKHSFSRFFGLGEKEQEPEIAEHDTNKEEILEIPVNAIVPNRFQ PRTIFSDEKIKELAMTIHTHGIIQPIVVRHTEEEGQYELIAGERRWRAVQSLEWEKIP AIIKDFSDTETASVALIENLQREELSSIEEAHAYARLLELHDLTQEALAQRLGKGQST IANKLRLLKLPQPVQEAIMEKKITERHARALIPLKQPELQVTLLTEIIEKSLNVKQTE DRVVKMLEQGQRKPKPRRKAFSRDTRIAMNTIRQSLSMVEDSGVKLNTEEEEFEEYIQ LTIRIPK*" gene complement(4028404..4029255) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" downshifts complement(4028423) /Source="Nicolas_upshifts" /id="D2125" /incds=0 /nref=245 /ntot=265 /MaxReadThrough="2.30868" /MaxDrop="6.68899" /score="29.5496038" /energy="-14.5" /TU="NA" /idTUdmin="U3236" /TUdmin="-1" /isTUend="TRUE" S_feature complement(4029256..4029376) /Source="Nicolas_S_feature" /locus_tag="new_4208749_4208869_c" /HighExp="LBGstat, G135, G180, H2O2, dia15, G150, Paraq, T0.30H, Oxctl, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1577" CDS complement(4029377..4030096) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" /EC_number="2.1.1.170" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12001236, 17238915, 17573471, 19622680, 24509311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12001236, 17238915, 17573471, 19622680, 24509311; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-methylguanosine methyltransferase (16S rRNA, nucleotide G527)" /protein_id="NP_391980.1" /db_xref="EnsemblGenomes-Gn:BSU41000" /db_xref="EnsemblGenomes-Tr:CAB16137" /db_xref="GOA:P25813" /db_xref="InterPro:IPR003682" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XDZ" /db_xref="SubtiList:BG10058" /db_xref="UniProtKB/Swiss-Prot:P25813" /translation="MNIEEFTSGLAEKGISLSPRQLEQFELYYDMLVEWNEKINLTSI TEKKEVYLKHFYDSITAAFYVDFNQVNTICDVGAGAGFPSLPIKICFPHLHVTIVDSL NKRITFLEKLSEALQLENTTFCHDRAETFGQRKDVRESYDIVTARAVARLSVLSELCL PLVKKNGLFVALKAASAEEELNAGKKAITTLGGELENIHSFKLPIEESDRNIMVIRKI KNTPKKYPRKPGTPNKSPIEG*" gene complement(4029377..4030096) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" CDS complement(4030110..4031996) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11914360, 14993678, 17062623, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA uridine 5-carboxymethylaminomethyl modification enzyme" /protein_id="NP_391981.1" /db_xref="EnsemblGenomes-Gn:BSU41010" /db_xref="EnsemblGenomes-Tr:CAB16138" /db_xref="GOA:P25812" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004416" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR026904" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10059" /db_xref="UniProtKB/Swiss-Prot:P25812" /translation="MGYEAGQYDVIVIGAGHAGVEAALASARQGAKTLVLTINLDMVA FMPCNPSVGGPAKGIVVREIDALGGEMGRNIDKTHIQMRMLNTGKGPAVRALRAQADK FQYQHEMKNTLEKEPNLTLLQGIVERLIVEDGECRGVITQTGAHYRAKAVVMTTGTYL RGRIILGDLSYSSGPNNQQPSIKLSEHLEELGFDLVRFKTGTPPRVKSDTIDYSKTEI QPGDDVPRAFSYETVEYITDQLPCWLTYTSPETHEIIDSNLHRSPMYSGMIKGTGPRY CPSIEDKVVRFNDKPRHQIFLEPEGRNTQEVYVQGLSTSLPEDVQQRMLATIPGLENV QMMRAGYAIEYDAIVPTQLWPTLETKKITNLYTAGQINGTSGYEEAAGQGIMAGINAG RKALGKEEVILSRSDAYIGVLIDDLVTKGTNEPYRLLTSRAEYRLLLRHDNADLRLTE IGHRIGLISDERYAAFEKKKAAIEAEKKRLHSVIIKPSPENQEYIRSLGGSELKDGVR GTDLMKRPEMNYETVTKLAPPEVPVPQDVAEQVEIQVKYEGYIEKSLQQVEKLKKMEN KKIPDRIDYDAIKGIATEARQKLKNVRPLSVAQASRISGVNPADISILLVYLEQGRIA KIAE*" gene complement(4030110..4031996) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" CDS complement(4032017..4033396) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" /EC_number="3.6.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15522079, 15616586, 19052377, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA modification GTPase and tRNA-U34 5-formylation enzyme" /protein_id="NP_391982.1" /db_xref="EnsemblGenomes-Gn:BSU41020" /db_xref="EnsemblGenomes-Tr:CAB16139" /db_xref="GOA:P25811" /db_xref="InterPro:IPR004520" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR018948" /db_xref="InterPro:IPR025867" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031168" /db_xref="SubtiList:BG10060" /db_xref="UniProtKB/Swiss-Prot:P25811" /translation="MDTIAAISTPMGEGAIAIVRLSGPEAIQIADKIYKGPKGKTLSS VESHTIHYGHIVDRPSDRVVEEVMVSVLKAPRTFTREDVIEINCHGGIVTVNQVLQLA LREGARLAEPGEFTKRAFLNGRIDLSQAEAVMDLIRAKTDRAMNVAMNQMEGRLSALV RRLRSEILETLAHVEVNIDYPEYDDVEEMTHQILVEKATAVKKEIETLLRTSEQGKIL REGLSTVIIGRPNVGKSSLLNSLVHEAKAIVTDIPGTTRDVIEEYVNVRGVPLRLVDT AGIRETEDIVERIGVERSRQVLKEADLILLVLNYSEELSEEDVKLFEAVEGMDVIVIL NKTDLEPKIDTERVRELANGRPVVTTSLLKEEGINDLEEAIQSLFYTGAIESGDLTYV SNTRHITILQQAKRAIEDALSGIEQDVPIDMVQIDLTRCWELLGEIIGDSVHESLIDQ LFSQFCLGK*" gene complement(4032017..4033396) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" S_feature complement(4033397..4033527) /Source="Nicolas_S_feature" /locus_tag="new_4212890_4213020_c" /HighExp="dia15, Diami, LBGstat, H2O2, Paraq, dia5, G180, T0.30H, LBGexp, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1578" promotor_-10 complement(4033519..4033538) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(4033527) /Source="Nicolas_upshifts" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" promotor_-35 complement(4033554..4033558) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(4033582..4033601) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-10" upshifts complement(4033592) /Source="Nicolas_upshifts" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" promotor_-35 complement(4033615..4033622) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-35" promotor_-35 4033682..4033688 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 4033693..4035978 /Source="Nicolas_S_feature" /locus_tag="new_4213186_4215471" /HighExp="T0.30H, C30, T1.0H, T1.30H, S2, T0.0H, T-1.10H, T-0.40H, T-1.40H, C90" /AntisenseName="oxaAA" /AntisenseCor="-0.20593684080740801" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.685" /TUlongSig="NA" /TUlongPSig="NA" /label="S1579" upshifts 4033693 /Source="Nicolas_upshifts" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" promotor_-10 4033703..4033722 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(4033707..4034333) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1487728, 12813085, 26883633, 27776484; Product type f: factor" /codon_start=1 /transl_table=11 /product="SpoIIIJ-associated RNA/ssDNA-binding protein" /protein_id="NP_391983.1" /db_xref="EnsemblGenomes-Gn:BSU41030" /db_xref="EnsemblGenomes-Tr:CAB16140" /db_xref="GOA:Q01620" /db_xref="InterPro:IPR001374" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR032782" /db_xref="InterPro:IPR034079" /db_xref="InterPro:IPR036867" /db_xref="SubtiList:BG10061" /db_xref="UniProtKB/Swiss-Prot:Q01620" /translation="MRNVTAAGRNVDEAVQSGLQELGLTKDKVEITVIEEGNKGFLGI FGKKPAIVKLVEKIDPIQQAKLYLQTIAEAIAGKSDVTVQESKKTVRYHITGEKAALL IGKRGQTLNALETLTQLALNRYPGQYKNVTVDAENYRLKRKETLSQLAIKLADQVLKT KKSIQLEPMPSSERKIIHDTLSGYANHQIKTYSMGEGENRHLVISHKR*" gene complement(4033707..4034333) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" downshifts complement(4033724) /Source="Nicolas_upshifts" /id="D2126" /incds=0 /nref=229 /ntot=258 /MaxReadThrough="2.29192" /MaxDrop="6.32351" /score="24.2602773" /energy="-14.1" /TU="NA" /idTUdmin="U3239" /TUdmin=0 /isTUend="TRUE" CDS complement(4034330..4035115) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_391984.1" /db_xref="EnsemblGenomes-Gn:BSU41040" /db_xref="EnsemblGenomes-Tr:CAB16141" /db_xref="GOA:Q01625" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG10062" /db_xref="UniProtKB/Swiss-Prot:Q01625" /translation="MLLKRRIGLLLSMVGVFMLLAGCSSVKEPITADSPHFWDKYVVY PLSELITYVAKLTGDNYGLSIILVTILIRLLILPLMIKQLRSSKAMQALQPEMQKLKE KYSSKDQKTQQKLQQETMALFQKHGVNPLAGCFPILIQMPILIGFYHAIMRTQAISEH SFLWFDLGEKDPYYILPIVAGVATFVQQKLMMAGNAQQNPQMAMMLWIMPIMIIVFAI NFPAALSLYWVVGNLFMIAQTFLIKGPDIKKNPEPQKAGGKKK*" gene complement(4034330..4035115) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" promotor_-10 complement(4035160..4035179) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(4035172) /Source="Nicolas_upshifts" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" S_feature complement(4035174..4035259) /Source="Nicolas_S_feature" /locus_tag="new_4214667_4214752_c" /HighExp="G135, G180, H2O2, Oxctl, Paraq, G150, Cold, LPh, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1580" promotor_-35 complement(4035191..4035197) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(4035260..4035610) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" /EC_number="3.1.26.5" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16061811, 16163391, 16980484, 17299131, 21347352, 24580115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein component of ribonuclease P (RNase P) (substrate specificity)" /protein_id="NP_391985.1" /db_xref="EnsemblGenomes-Gn:BSU41050" /db_xref="EnsemblGenomes-Tr:CAB16142" /db_xref="GOA:P25814" /db_xref="InterPro:IPR000100" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020539" /db_xref="InterPro:IPR020568" /db_xref="PDB:1A6F" /db_xref="PDB:4JG4" /db_xref="SubtiList:BG10063" /db_xref="UniProtKB/Swiss-Prot:P25814" /translation="MKKRNRLKKNEDFQKVFKHGTSVANRQFVLYTLDQPENDELRVG LSVSKKIGNAVMRNRIKRLIRQAFLEEKERLKEKDYIIIARKPASQLTYEETKKSLQH LFRKSSLYKKSSSK*" gene complement(4035260..4035610) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" S_feature complement(4035611..4035761) /Source="Nicolas_S_feature" /locus_tag="new_4215104_4215254_c" /HighExp="G135, G180, Oxctl, H2O2, Paraq, Cold, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1581" CDS complement(4035762..4035896) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7539334, 9371771, 12682299, 23002217, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7539334, 9371771, 12682299, 23002217, 25182490; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L34" /protein_id="NP_391986.1" /db_xref="EnsemblGenomes-Gn:BSU41060" /db_xref="EnsemblGenomes-Tr:CAB16143" /db_xref="GOA:P05647" /db_xref="InterPro:IPR000271" /db_xref="InterPro:IPR020939" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10064" /db_xref="UniProtKB/Swiss-Prot:P05647" /translation="MKRTFQPNNRKRSKVHGFRSRMSSKNGRLVLARRRRKGRKVLSA *" gene complement(4035762..4035896) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" promotor_no_box 4035920..4036020 /Source="Nicolas_upshift_promotors" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(4035932..4035951) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(4035942) /Source="Nicolas_upshifts" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" S_feature complement(4035944..4036012) /Source="Nicolas_S_feature" /locus_tag="new_4215437_4215505_c" /HighExp="Oxctl, G180, Paraq, H2O2, LBGstat, GM 120, MG-0.2, HPh, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1582" promotor_-35 complement(4035967..4035974) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 4035980..>4036113 /Source="Nicolas_S_feature" /locus_tag="new_4215473_4215670" /HighExp="T0.30H, C30, T1.0H, T1.30H, T0.0H, T-0.40H, S2, T-1.10H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.048" /TUlongSig="NA" /TUlongPSig="NA" /label="S1583" upshifts 4035980 /Source="Nicolas_upshifts" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" promotor_-10 complement(4035998..4036017) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(4036012) /Source="Nicolas_upshifts" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" promotor_-35 complement(4036033..4036037) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" ORIGIN 1 atctttttcg gcttttttta gtatccacag aggttatcga caacattttc acattaccaa 61 cccctgtgga caaggttttt tcaacaggtt gtccgctttg tggataagat tgtgacaacc 121 attgcaagct ctcgtttatt ttggtattat atttgtgttt taactcttga ttactaatcc 181 tacctttcct ctttatccac aaagtgtgga taagttgtgg attgatttca cacagcttgt 241 gtagaaggtt gtccacaagt tgtgaaattt gtcgaaaagc tatttatcta ctatattata 301 tgttttcaac atttaatgtg tacgaatggt aagcgccatt tgctcttttt ttgtgttcta 361 taacagagaa agacgccatt ttctaagaaa aggagggacg tgccggaaga tggaaaatat 421 attagacctg tggaaccaag cccttgctca aatcgaaaaa aagttgagca aaccgagttt 481 tgagacttgg atgaagtcaa ccaaagccca ctcactgcaa ggcgatacat taacaatcac 541 ggctcccaat gaatttgcca gagactggct ggagtccaga tacttgcatc tgattgcaga 601 tactatatat gaattaaccg gggaagaatt gagcattaag tttgtcattc ctcaaaatca 661 agatgttgag gactttatgc cgaaaccgca agtcaaaaaa gcggtcaaag aagatacatc 721 tgattttcct caaaatatgc tcaatccaaa atatactttt gatacttttg tcatcggatc 781 tggaaaccga tttgcacatg ctgcttccct cgcagtagcg gaagcgcccg cgaaagctta 841 caacccttta tttatctatg ggggcgtcgg cttagggaaa acacacttaa tgcatgcgat 901 cggccattat gtaatagatc ataatccttc tgccaaagtg gtttatctgt cttctgagaa 961 atttacaaac gaattcatca actctatccg agataataaa gccgtcgact tccgcaatcg 1021 ctatcgaaat gttgatgtgc ttttgataga tgatattcaa tttttagcgg ggaaagaaca 1081 aacccaggaa gaatttttcc atacatttaa cacattacac gaagaaagca aacaaatcgt 1141 catttcaagt gaccggccgc caaaggaaat tccgacactt gaagacagat tgcgctcacg 1201 ttttgaatgg ggacttatta cagatatcac accgcctgat ctagaaacga gaattgcaat 1261 tttaagaaaa aaggccaaag cagagggcct cgatattccg aacgaggtta tgctttacat 1321 cgcgaatcaa atcgacagca atattcggga actcgaagga gcattaatca gagttgtcgc 1381 ttattcatct ttaattaata aagatattaa tgctgatctg gccgctgagg cgttgaaaga 1441 tattattcct tcctcaaaac cgaaagtcat tacgataaaa gaaattcaga gggtagtagg 1501 ccagcaattt aatattaaac tcgaggattt caaagcaaaa aaacggacaa agtcagtagc 1561 ttttccgcgt caaatcgcca tgtacttatc aagggaaatg actgattcct ctcttcctaa 1621 aatcggtgaa gagtttggag gacgtgatca tacgaccgtt attcatgcgc atgaaaaaat 1681 ttcaaaactg ctggcagatg atgaacagct tcagcagcat gtaaaagaaa ttaaagaaca 1741 gcttaaatag caggaccggg gatcaatcgg ggaaagtgtg aataactttt cggaagtcat 1801 acacagtctg tccacatgtg gataggctgt gtttcctgtc tttttcacaa cttatccaca 1861 aatccacagg ccctactatt acttctacta ttttttataa atatatatat taatacatta 1921 tccgttagga ggataaaaat gaaattcacg attcaaaaag atcgtcttgt tgaaagtgtc 1981 caagatgtat taaaagcagt ttcatccaga accacgattc ccattctgac tggtattaaa 2041 attgttgcat cagatgatgg agtatccttt acagggagtg actcagatat ttctattgaa 2101 tccttcattc caaaagaaga aggagataaa gaaatcgtca ctattgaaca gcccggaagc 2161 atcgttttac aggctcgctt ttttagtgaa attgtaaaaa aattgccgat ggcaactgta 2221 gaaattgaag tccaaaatca gtatttgacg attatccgtt ctggtaaagc tgaatttaat 2281 ctaaacggac tggatgctga tgaatatccg cacttgccgc agattgaaga gcatcatgcg 2341 attcagatcc caactgattt gttaaaaaat ctaatcagac aaacagtatt tgcagtgtcc 2401 acctcagaaa cacgccctat cttgacaggt gtaaactgga aagtggagca aagtgaatta 2461 ttatgcactg caacggatag ccaccgtctt gcattaagaa aggcgaaact tgatattcca 2521 gaagacagat cttataacgt cgtgattccg ggaaaaagtt taactgaact cagcaagatt 2581 ttagatgaca accaggaact tgtagatatc gtcatcacag aaacccaagt tctgtttaaa 2641 gcgaaaaacg tcttgttctt ctcacggctt ctggacggga attatccaga cacaaccagc 2701 ctgattccgc aagacagcaa aacagaaatc attgtgaaca caaaagaatt ccttcaggcc 2761 attgatcgtg catctctttt agctagagag ggacgcaaca acgttgtaaa actgtccgca 2821 aaaccggctg aatccattga aatttcttcc aattcgccag aaatcggtaa agttgtggaa 2881 gcaattgttg cggatcaaat tgaaggtgag gaattaaata tctcttttag tccaaaatat 2941 atgctggatg cactaaaggt gcttgaagga gcagaaatac gcgtaagctt tacaggcgca 3001 atgagacctt tcttaattcg cacgccgaat gatgaaacga ttgtacagct tatccttcct 3061 gtcagaacct attaatccga tacactgctg ccgacccgtc ggcagctttt ctattcggta 3121 tctgctccga caagttttcc ctttccctaa ttcgtttttt tttagtacaa ttagatatta 3181 gtgatatttg aaagaggtcg atataatggc aaatccgatt tcaattgata cagagatgat 3241 tacactcgga caattcttaa aattagccga tgtgattcag tctggcggta tggcgaagtg 3301 gtttttaagc gagcatgaag tgcttgtgaa cgatgagccg gacaaccgcc ggggcagaaa 3361 gctgtatgtt ggagatgtgg tagagattga aggatttggt tcatttcaag tcgtcaatta 3421 aagcgggtga cactgattgt atatccagaa cttagaactg acatcttacc gcaactacga 3481 ccatgctgaa cttcaatttg aaaataaagt aaatgtgatc atcggagaaa acgcccaggg 3541 gaagacaaac ctcatggagg cgatctatgt cttgtccatg gcgaaatcgc accggacatc 3601 aaatgacaaa gaacttatac ggtgggacaa agactatgct aaaatagagg gaagagtgat 3661 gaagcaaaac ggggcgatcc cgatgcagct cgtcatctcc aaaaagggta aaaagggcaa 3721 ggtcaatcat attgaacagc aaaagctcag ccagtatgtc ggggccctca acaccattat 3781 gttcgcgccg gaagatttaa atcttgtaaa gggaagccct caagtgagaa ggcggtttct 3841 tgacatggaa atcggacagg tttctcccgt ctaccttcat gatctttctc tttaccagaa 3901 aatcctttcc cagcggaatc attttttgaa acagctgcaa acaagaaaac aaactgaccg 3961 gacgatgctc gatgttctga ccgatcagct tgtagaagtt gcagcaaaag tcgtcgtaaa 4021 acgcctgcag tttacagcac agctcgagaa atgggcgcag cccatccatg caggcatctc 4081 aagagggctt gaagaactga ccctgaaata ccatacagct cttgatgtat cagatcccct 4141 agatttgtcg aaaataggag atagctatca agaagcgttt tctaaattaa gagaaaaaga 4201 aattgagcgt ggtgtgacgc tgtcagggcc tcatcgcgat gatgttcttt tctatgtgaa 4261 cggacgcgat gtgcagacgt atggttctca aggacagcag cgaacgacgg cgttgtccct 4321 taagctggcg gagattgacc tgatccatga agaaatcgga gaatatccca ttttactatt 4381 ggatgatgta ctgagtgaac tggatgatta tcgccagtca cacttgcttc atacgatcca 4441 aggccgtgta caaacgtttg tcacaacgac aagcgttgat ggcattgatc acgaaacctt 4501 acgtcaagca ggaatgttcc gtgtgcaaaa tggtgcgtta gtgaagtgaa gaaatgaggt 4561 gagcaattgt atattcattt aggtgatgac tttgtggttt caacacgaga tattgtcggc 4621 atttttgact ttaaagccaa catgtcgcct attgttgaag aatttctgaa aaaacagaaa 4681 cacaaggtgg tgccttccgt aaacggcacg cccaaatcta tcgtagtcac ggttcagaat 4741 atatattact ctcccttatc ttccagcaca ttaaaaaaac gtgcgcaatt tatgtttgaa 4801 atagattctt agaaattttt tatcacgaat atatcgttta gaaaagtgta ggtgaatgac 4861 gtggctatgg aacagcagca aaacagttat gatgaaaatc agatacaggt actagaagga 4921 ttggaagctg ttcgtaaaag accggggatg tatatcggtt cgacaaacag caaaggcctt 4981 caccacttgg tatgggaaat tgtcgacaat agtattgacg aagccctcgc cggttattgt 5041 acggatatca atatccaaat cgaaaaagac aacagtatca cggttgtaga taatggccgc 5101 ggtattccag tcggtattca tgaaaaaatg ggccgtcctg cggtagaagt cattatgacg 5161 gtgcttcatg ccggaggaaa atttgacgga agcggctata aagtatccgg aggattacac 5221 ggtgtaggtg cgtcggtcgt aaacgcacta tcaacagagc ttgatgtgac ggttcaccgt 5281 gacggtaaaa ttcaccgcca aacctataaa cgcggagttc cggttacaga ccttgaaatc 5341 attggcgaaa cggatcatac aggaacgacg acacattttg tcccggaccc tgaaattttc 5401 tcagaaacaa ccgagtatga ttacgatctg cttgccaacc gcgtgcgtga attagccttt 5461 ttaacaaagg gcgtaaacat cacgattgaa gataaacgtg aaggacaaga gcgcaaaaat 5521 gaataccatt acgaaggcgg aattaaaagt tatgtagagt atttaaaccg ctctaaagag 5581 gttgtccatg aagagccgat ttacattgaa ggcgaaaagg acggcattac ggttgaagtg 5641 gctttgcaat acaatgacag ctacacaagc aacatttact cgtttacaaa caacattaac 5701 acgtacgaag gcggtaccca tgaagctggc ttcaaaacgg gcctgactcg tgttatcaac 5761 gattacgcca gaaaaaaagg gcttattaaa gaaaatgatc caaacctaag cggagatgac 5821 gtaagggaag ggctgacagc gattatttca atcaaacacc ctgatccgca gtttgagggc 5881 caaacaaaaa caaagctggg caactcagaa gcacggacga tcaccgatac gttattttct 5941 acggcgatgg aaacatttat gctggaaaat ccagatgcag ccaaaaaaat tgtcgataaa 6001 ggtttaatgg cggcaagagc aagaatggct gcgaaaaaag cgcgtgaact aacacgccgt 6061 aagagtgctt tggaaatttc aaacctgccc ggtaagttag cggactgctc ttcaaaagat 6121 ccgagcatct ccgagttata tatcgtagag ggtgactctg ccggaggatc tgctaaacaa 6181 ggacgcgaca gacatttcca agccattttg ccgcttagag gtaaaatcct aaacgttgaa 6241 aaggccagac tggataaaat cctttctaac aacgaagttc gctctatgat cacagcgctc 6301 ggcacaggta tcggagaaga cttcaacctt gagaaagccc gttaccacaa agttgtcatt 6361 atgacagatg ccgatgttga cggcgcgcac atcagaacac tgctgttaac gttcttttac 6421 agatatatgc gccaaattat cgaaaatggc tacgtgtaca ttgcgcagcc gccgctctac 6481 aaggttcaac aggggaaacg cgttgaatat gcatacaatg acaaggagct tgaagagctg 6541 ttaaaaactc ttcctcaaac gcctaagcct ggactgcagc gttacaaagg tcttggtgaa 6601 atgaatgcca cccagctatg ggagacaacc atggatccta gctccagaac acttcttcag 6661 gtaactcttg aagatgcaat ggatgcggat gagacttttg aaatgcttat gggcgacaag 6721 gtagaaccgc gccgaaactt catagaagcg aatgcgagat acgttaaaaa tcttgacatc 6781 taatcataaa aagccttatt tccaataaga aataaggctt ttttctgaac aagatcagat 6841 gcagcgatgc ctgcaatacc tatatattct agcaatttaa tgtgtataat cataagttta 6901 ttgatataat ggagaatagt gaaatcgtat tgaaggtcat aatggacaat ctactcccac 6961 atatttcatg tgatacttca gggaggtttt ttaatgagtg aacaaaacac accacaagtt 7021 cgtgaaataa atatcagtca ggaaatgcgt acgtccttct tggattatgc aatgagcgtt 7081 atcgtgtccc gtgctcttcc ggatgttcgt gacggtttaa aaccggttca tagacggatt 7141 ttgtatgcaa tgaatgattt aggcatgaca agtgacaagc cttataaaaa atccgcgcgt 7201 atcgttggag aagttatcgg gaaataccac ccgcacggtg attcagcggt atatgaatcc 7261 atggtcagaa tggctcagga tttcaactac cgttatatgc tcgttgacgg tcacggaaac 7321 ttcggttctg ttgacggaga ctcagcggcg gccatgcgtt atacagaagc acgaatgtct 7381 aaaatctcaa tggagattct tcgcgacatc acaaaagaca caatcgatta ccaggataac 7441 tatgacgggt cagaaagaga acctgtcgtt atgccttcaa ggttcccgaa tctgctcgtg 7501 aacggtgctg ccggcattgc ggtaggtatg gcaacaaaca ttcctccgca ccagctggga 7561 gaaatcattg acggtgtact tgctgttagt gagaatccgg acattacaat tccagagctt 7621 atggaagtca ttccagggcc tgatttcccg accgcgggtc aaatcttggg acgcagcggt 7681 atccggaaag catacgaatc aggccgaggc tctatcacga tccgggcaaa agctgagatc 7741 gaacaaacat cttcgggtaa agaaagaatt atcgttacag agttacctta ccaagtaaat 7801 aaggcgaaat taattgagaa aattgctgat ctcgtaaggg acaaaaagat agagggtatc 7861 acagatctgc gtgatgagtc agatcgtaca ggtatgagaa ttgtcattga aatcagacgc 7921 gatgccaatg cgaatgttat cttaaacaat ctgtacaaac aaactgctct acaaacatct 7981 tttggcatca acctgcttgc gcttgttgat ggccagccga aagttttaac tcttaagcaa 8041 tgcctggagc attaccttga ccatcaaaaa gttgtcatta gacgccgtac tgcttatgaa 8101 ttgcgtaaag cagaagcgag agctcatatc ttggaaggat tgagagttgc actggatcat 8161 ctcgatgcag ttatctccct tatccgtaat tctcaaacgg ctgaaattgc gagaacaggt 8221 ttaattgaac aattctcact gacagagaag caagcacaag cgatccttga catgaggctc 8281 cagcgtttaa cgggactgga acgtgaaaag atcgaagaag aataccagtc tcttgttaaa 8341 ttaattgcag agctaaaaga catcttggca aatgaatata aagtgcttga gatcattcgt 8401 gaagaactca cggaaatcaa agagcgtttt aacgatgaaa gacgtactga gatcgtcact 8461 tctggactgg agacaattga agatgaagat ctcatcgaga gagaaaatat cgtagttact 8521 ctgacgcaca acggatacgt caaacgtctt cctgcatcaa cttaccgcag tcaaaaacgg 8581 ggcggaaaag gtgtacaagg tatgggaaca aacgaagatg atttcgttga acatttgatc 8641 tctacgtcaa ctcatgacac gattctcttc ttctcgaaca aggggaaagt gtatcgtgca 8701 aaagggtatg aaatccctga atacggcaga acggcaaaag gaatcccgat tattaacctg 8761 ctggaggtag aaaagggtga gtggatcaac gcgattattc cagtcacgga attcaatgcg 8821 gagctttacc tcttcttcac tacaaagcat ggggtttcaa aacgaacatc gctatctcaa 8881 ttcgctaata tccgcaacaa tggtctaatt gctctgagtc ttcgtgaaga tgatgaactg 8941 atgggtgtac gtctgactga cggcacaaaa caaatcatca ttggaacgaa aaacggttta 9001 ctgattcgtt tccctgaaac agatgtccga gagatgggaa gaactgcggc gggcgtaaaa 9061 ggcatcaccc tgacggatga cgacgttgtt gtcggcatgg agattttaga ggaagaatca 9121 cacgtcctta tcgtaactga aaaagggtac ggaaaacgaa ctcctgctga agagtacaga 9181 acccaaagcc ggggcggaaa aggactcaaa acagcgaaaa tcaccgagaa caacggccaa 9241 ctagtagcag tgaaagctac taaaggtgaa gaggatctaa tgattattac agctagcggc 9301 gtactcatca gaatggacat caatgatatc tccatcaccg gacgtgtcac tcaaggtgtg 9361 cgtctcatca gaatggcaga agaagagcat gttgctacag tagctttagt tgagaaaaac 9421 gaagaagatg agaatgaaga agaacaagaa gaagtgtgaa aaaaagcgca gctgaaatag 9481 ctgcgctttt ttgtgtcata accctttaca gtcataaaaa ttatggtata atcatttctg 9541 ttgtcttttt aaagacacaa gcatgaccat tatgactagt aaaaactttt tcaaaaaagt 9601 attgacctag ttaactaaaa atgttactat taagtagtcg ctttgagaga agcacacaaa 9661 gttctttgaa aactaaacaa gacaaaacgt acctgttaat tcatttttat aaatcgcaca 9721 gcgatgtgcg tagtcagtca aactagggcc tgcacgacgc aggtcacaca ggtgtcgccg 9781 caggatgcgg tgaacttaac ctgtgatcca tttatcggag agtttgatcc tggctcagga 9841 cgaacgctgg cggcgtgcct aatacatgca agtcgagcgg acagatggga gcttgctccc 9901 tgatgttagc ggcggacggg tgagtaacac gtgggtaacc tgcctgtaag actgggataa 9961 ctccgggaaa ccggggctaa taccggatgg ttgtttgaac cgcatggttc aaacataaaa 10021 ggtggcttcg gctaccactt acagatggac ccgcggcgca ttagctagtt ggtgaggtaa 10081 cggctcacca aggcgacgat gcgtagccga cctgagaggg tgatcggcca cactgggact 10141 gagacacggc ccagactcct acgggaggca gcagtaggga atcttccgca atggacgaaa 10201 gtctgacgga gcaacgccgc gtgagtgatg aaggttttcg gatcgtaaag ctctgttgtt 10261 agggaagaac aagtgccgtt cgaatagggc ggtaccttga cggtacctaa ccagaaagcc 10321 acggctaact acgtgccagc agccgcggta atacgtaggt ggcaagcgtt gtccggaatt 10381 attgggcgta aagggctcgc aggcggtttc ttaagtctga tgtgaaagcc cccggctcaa 10441 ccggggaggg tcattggaaa ctggggaact tgagtgcaga agaggagagt ggaattccac 10501 gtgtagcggt gaaatgcgta gagatgtgga ggaacaccag tggcgaaggc gactctctgg 10561 tctgtaactg acgctgagga gcgaaagcgt ggggagcgaa caggattaga taccctggta 10621 gtccacgccg taaacgatga gtgctaagtg ttagggggtt tccgcccctt agtgctgcag 10681 ctaacgcatt aagcactccg cctggggagt acggtcgcaa gactgaaact caaaggaatt 10741 gacgggggcc cgcacaagcg gtggagcatg tggtttaatt cgaagcaacg cgaagaacct 10801 taccaggtct tgacatcctc tgacaatcct agagatagga cgtccccttc gggggcagag 10861 tgacaggtgg tgcatggttg tcgtcagctc gtgtcgtgag atgttgggtt aagtcccgca 10921 acgagcgcaa cccttgatct tagttgccag cattcagttg ggcactctaa ggtgactgcc 10981 ggtgacaaac cggaggaagg tggggatgac gtcaaatcat catgcccctt atgacctggg 11041 ctacacacgt gctacaatgg acagaacaaa gggcagcgaa accgcgaggt taagccaatc 11101 ccacaaatct gttctcagtt cggatcgcag tctgcaactc gactgcgtga agctggaatc 11161 gctagtaatc gcggatcagc atgccgcggt gaatacgttc ccgggccttg tacacaccgc 11221 ccgtcacacc acgagagttt gtaacacccg aagtcggtga ggtaaccttt taggagccag 11281 ccgccgaagg tgggacagat gattggggtg aagtcgtaac aaggtagccg tatcggaagg 11341 tgcggctgga tcacctcctt tctaaggata ttttacggaa tataagacct tgggtcttat 11401 aaacagaacg ttccctgtct tgtttagttt tgaaggaact ttgttccttg aataagttaa 11461 gatgggcctg tagctcagct ggttagagcg cacgcctgat aagcgtgagg tcggtggttc 11521 gagtccactc aggcccacca tcttatataa cggggcctta gctcagctgg gagagcgcct 11581 gctttgcacg caggaggtca gcggttcgat cccgctaggc tccaccaacg tgttctttga 11641 aaactagata acagtagaca tcacattcaa ttagtaacac aagatatcac atagtgattc 11701 tttttaacgg ttaagttaga aagggcgcac ggtggatgcc ttggcactag gagccgatga 11761 aggacgggac gaacaccgat atgcttcggg gagctgtaag caagctttga tccggagatt 11821 tccgaatggg gaaacccacc actcgtaatg gagtggtatc catatctgaa ttcataggat 11881 atgagaaggc agacccgggg aactgaaaca tctaagtacc cggaggaaga gaaagcaaat 11941 gcgattccct gagtagcggc gagcgaaacg ggatcagccc aaaccaagag gcttgcctct 12001 tggggttgta ggacactctg tacggagtta caaaggaacg aggtagatga agaggtctgg 12061 aaaggcccgc cataggaggt aacagccctg tagtcaaaac ttcgttctct cctgagtgga 12121 tcctgagtac ggcggaacac gtgaaattcc gtcggaatcc gggaggacca tctcccaagg 12181 ctaaatactc cctagtgacc gatagtgaac cagtaccgtg agggaaaggt gaaaagcacc 12241 ccggaagggg agtgaaagag atcctgaaac cgtgtgccta caagtagtca gagcccgtta 12301 acgggtgatg gcgtgccttt tgtagaatga accggcgagt tacgatctcg tgcaaggtta 12361 agcagaagat gcggagccgc agcgaaagcg agtctgaata gggcgcatga gtacgtggtc 12421 gtagacccga aaccaggtga tctacccatg tccagggtga agttcaggta acactgaatg 12481 gaggcccgaa cccacgcacg ttgaaaagtg cggggatgag gtgtgggtag gggtgaaatg 12541 ccaatcgaac ctggagatag ctggttctct ccgaaatagc tttagggcta gcctcaaggt 12601 aagagtcttg gaggtagagc actgattgga ctaggggccc ctaccgggtt accgaattca 12661 gtcaaactcc gaatgccaat gacttatcct tgggagtcag actgcgagtg ataagatccg 12721 tagtcgaaag ggaaacagcc cagaccgcca gctaaggtcc caaagtatac gttaagtgga 12781 aaaggatgtg gagttgctta gacaaccagg atgttggctt agaagcagcc accatttaaa 12841 gagtgcgtaa tagctcactg gtcgagtgac tctgcgccga aaatgtaccg gggctaaacg 12901 tatcaccgaa gctgcggact gttcttcgaa cagtggtagg agagcgttct aagggctgtg 12961 aagccagacc ggaaggactg gtggagcgct tagaagtgag aatgccggta tgagtagcga 13021 aagaggggtg agaatcccct ccaccgaatg cctaaggttt cctgaggaag gctcgtccgc 13081 tcagggttag tcgggaccta agccgaggcc gaaaggcgta ggcgatggac aacaggttga 13141 tattcctgta ccacctcctc accatttgag caatgggggg acgcaggagg atagggtaag 13201 cgcggtattg gatatccgcg tccaagcagt taggctggga aataggcaaa tccgtttccc 13261 ataaggctga gctgtgatgg cgagcgaaat atagtagcga agttcctgat tccacactgc 13321 caagaaaagc ctctagcgag gtgagaggtg cccgtaccgc aaaccgacac aggtaggcga 13381 ggagagaatc ctaaggtgat cgagagaact ctcgttaagg aactcggcaa aatgaccccg 13441 taacttcggg agaaggggtg ctctgttagg gtgcaagccc gagagagccg cagtgaatag 13501 gcccaggcga ctgtttagca aaaacacagg tctctgcgaa gccgtaaggc gaagtatagg 13561 ggctgacgcc tgcccggtgc tggaaggtta agaggagcgc ttagcgtaag cgaaggtgcg 13621 aattgaagcc ccagtaaacg gcggccgtaa ctataacggt cctaaggtag cgaaattcct 13681 tgtcgggtaa gttccgaccc gcacgaaagg cgcaacgatc tgggcactgt ctcaacgaga 13741 gactcggtga aattatagta cctgtgaaga tgcaggttac ccgcgacagg acggaaagac 13801 cccgtggagc tttactgcag cctgatattg aatgttggta cagcttgtac aggataggta 13861 ggagccttgg aaaccggagc gccagcttcg gtggaggcat cggtgggata ctaccctggc 13921 tgtattgacc ttctaacccg ccgcccttat cgggcgggga gacagtgtca ggtgggcagt 13981 ttgactgggg cggtcgcctc ctaaaaggta acggaggcgc ccaaaggttc cctcagaatg 14041 gttggaaatc attcgcagag tgtaaaggca caagggagct tgactgcgag acctacaagt 14101 cgagcaggga cgaaagtcgg gcttagtgat ccggtggttc cgcatggaag ggccatcgct 14161 caacggataa aagctacccc ggggataaca ggcttatctc ccccaagagt ccacatcgac 14221 ggggaggttt ggcacctcga tgtcggctca tcgcatcctg gggctgtagt cggtcccaag 14281 ggttgggctg ttcgcccatt aaagcggtac gcgagctggg ttcagaacgt cgtgagacag 14341 ttcggtccct atccgtcgcg ggcgcaggaa atttgagagg agctgtcctt agtacgagag 14401 gaccgggatg gacgcaccgc tggtgtacca gttgttctgc caagggcatc gctgggtagc 14461 tatgtgcgga cgggataagt gctgaaagca tctaagcatg aagcccccct caagatgaga 14521 tttcccattc cgcaaggaag taagatccct gaaagatgat caggttgata ggtctgaggt 14581 ggaagtgtgg cgacacatgg agctgacaga tactaatcga tcgaggactt aaccatattt 14641 ttgaatgatg tcacacctgt tatctagttt tgagagaaca ctctcaattt gtttggtggc 14701 gatagcgaag aggtcacacc cgttcccata ccgaacacgg aagttaagct cttcagcgcc 14761 gatggtagtc gggggtttcc ccctgtgaga gtaggacgcc gccaagcaag cttaaaccca 14821 gctcaatgag ctgggttttt tgtttgttaa aaatgaagaa gaaactgtga agcgtattta 14881 gggaatttct tttctgatac taataaaaac tgctgaatta acacgtagtc atcacttata 14941 tgctgtgtta ataactcata ccaccattct gtttcatacc ttgcaatcat cccaacgttg 15001 tacaaaatca aataatgaat tgtcatttcg ggaagcctca gaaattgctc cctttgagaa 15061 gggatataat attggttctt ttccatgtca aacaataagc tggtcgatgt ccatggctcc 15121 ttgtcttgtg gtgaaatttc gaacagcagc ccgtgttcat ttttttttgt aaaagaccat 15181 tgataatgat gggacatgta ttcagcaaac cttgaatcag acattttgta attgattact 15241 acttcctccg gtacaaaaat ttcgttctta tccttctcaa cttttgtcat aaatcgttct 15301 ttctgctgaa agtagaaaat atcgctaagt tctggaatgg ccattaataa ttttttcatg 15361 gtataccgtt catctactat atccgattgt ccgaataaat gtttcataaa atgtacgcat 15421 aggccattcc gttgtatttt cacttcatcg tcgctaaaac aataattttg tttctttcgt 15481 tttcttgttg ttacgccatg tgccagtact gatgtatggc ttggataatg aggatcacgt 15541 gtaattaagc atgctttgat aagctgtgcc attccataaa ataaaagaat cggtttgatt 15601 tctaagggag aatatgcggc ttgtttataa aacgattcgg catgctttaa gaaataaata 15661 aaccgttcac tgtttttaaa agagtttttt ttcgcatcgt taataccgtt taagatataa 15721 accttttcta gaaatttctg ggttgattca acggagtaaa atagcgctaa gtctttccac 15781 tcatgatatg tcatgtatat ttcttaatcc tttccgttat ctaaatattt caactctttc 15841 ccgcttcctt gacatgctct tggctagttg ataatctaca tataatattt tgccgaaaag 15901 agggggattt actaatgtgg gaaagtaaat tttcaaaaga aggcttaacg ttcgacgatg 15961 tgctgcttgt accagcaaag tctgaggtac ttccgcgtga tgtggattta tctgtagaac 16021 ttacaaaaac gttaaagcta aatattcctg tcatcagcgc aggtatggac actgtaacag 16081 aatcagcaat ggcaattgca atggcaagac agggcggctt gggcatcatt cacaaaaata 16141 tgtccattga acagcaggct gaacaagttg ataaagtaaa gcgttctgag cgcggcgtta 16201 tcacaaatcc cttcttttta actcctgatc accaagtatt tgatgcggag catttgatgg 16261 ggaaatacag aatttccggt gttccgattg taaataacga agaagaccag aagcttgttg 16321 gaattattac aaaccgtgac cttcgtttta tttctgacta ctcaatgaaa atcagcgacg 16381 tcatgacgaa agaagagcta gttactgcat ctgtaggaac tactctggat gaagctgaaa 16441 agattttgca gaaacataaa attgaaaagc ttcctctcgt agatgaccag aataaattaa 16501 aaggtcttat cacaattaaa gacattgaaa aagtcattga gttcccgaac tcatctaaag 16561 acattcacgg ccgcctgatc gttggcgcgg cagttggtgt aactggcgat acaatgactc 16621 gcgtcaaaaa gcttgttgaa gccaatgttg atgtgattgt tatcgataca gctcacggac 16681 actctcaagg cgttttaaac acagtcacaa aaatccgtga aacgtatccc gaattaaaca 16741 ttattgctgg aaacgtggca acagctgaag cgacaagagc gcttatcgaa gctggagcag 16801 acgttgtcaa agttggaata gggcctggtt caatttgtac tacacgtgtt gtagccggcg 16861 tgggtgttcc gcaaattaca gcaatttatg attgtgcgac tgaagcaaga aaacacggca 16921 aaacaatcat cgccgacggt gggattaaat tctctggcga tatcactaaa gcattggcag 16981 ccggcggaca tgctgttatg ctcggaagct tgcttgcagg cacatcagaa agccctggtg 17041 aaactgaaat ctaccaaggc agaagattta aggtataccg cggcatggga tcagttgctg 17101 caatggaaaa aggaagtaaa gaccgttact tccaagaaga aaacaaaaaa tttgttcctg 17161 aaggaattga aggacgcaca ccttacaaag ggccagttga agaaaccgtt tatcagctag 17221 tcggaggcct tcgttctggt atggggtatt gcgggtccaa agatctgcgt gcgctaagag 17281 aagaagctca gttcattcgc atgactggcg caggacttcg cgaaagccat ccgcatgacg 17341 tacagattac aaaagaatca cctaactata caatttcata ataaattgtt acaaattaaa 17401 aacatttgac agggtctctg actctgtcta ttttttttat actgattatg ataaaattta 17461 tactgttgtg cattgaaaat gtccttaacg gcttaattat agatgaagaa aatgaaatac 17521 ggaggtcgta cgattgaaca tcaagaaatg taaacagcta ctgatgtcat tggttgtgtt 17581 aactctagct gtcacgtgtc tggctccaat gtcaaaagcg aaagcagcca gcgatccaat 17641 tgatatcaat gcatctgctg ctattatgat cgaagcttct tcaggtaaaa ttctttacag 17701 taaaaatgca gataagagac tgccaattgc gagtatgaca aaaatgatga cagagtatct 17761 gttattggaa gcaattgatc aaggtaaagt gaaatgggac caaacctata cgcctgatga 17821 ctatgtgtat gaaatttccc aagataacag cttatcaaac gttcctcttc ggaaagacgg 17881 gaaatacaca gtaaaagaat tatatcaagc tacagcaatt tattctgcaa atgctgctgc 17941 tattgcgatt gcagaaatcg ttgccggttc tgaaactaag tttgttgaaa aaatgaatgc 18001 aaaagcaaaa gaactaggct taacagatta caaatttgtt aacgcaacag gtcttgaaaa 18061 caaagatctt cacgggcatc agcctgaggg gacaagcgta aatgaagaaa gtgaagtttc 18121 tgcaaaggat atggcggttc ttgcggatca cttgattact gactaccctg agatactgga 18181 gacttccagt atcgccaaaa cgaaattcag agaaggcacc gatgatgaaa tggacatgcc 18241 gaactggaat tttatgctga aggggcttgt cagcgagtat aaaaaagcga ctgtagacgg 18301 actgaaaaca ggttctactg actctgcggg ttcatgcttt acaggaacag ctgaacgcaa 18361 cggtatgcgt gtcatcactg ttgttttaaa cgcaaagggc aaccttcata caggccgttt 18421 cgatgaaacg aaaaaaatgt ttgattatgc tttcgacaat ttctccatga aagaaattta 18481 tgctgaaggc gatcaagtaa aaggccataa aacaatttca gttgataagg gtaaagagaa 18541 agaagtaggc attgtgacaa acaaggcgtt ctctcttcct gtcaaaaatg gtgaagaaaa 18601 gaattacaaa gcgaaggtca cactgaataa agacaactta actgctcctg tgaaaaaagg 18661 aaccaaggtt gggaagctga ctgcggaata cacaggtgat gaaaaggatt acggattcct 18721 taacagcgat ctggctggcg tagaccttgt tacaaaagaa aatgtagaaa aagcaaactg 18781 gtttgttttg acaatgcgca gtatcggcgg attttttgcc ggaatttggg gaagcattgt 18841 tgatacggta accggctggt tttaatcaat tgaaagagct ctgatggatg ttagggctct 18901 ttcgcgtaat atactgaaaa aacccaattt ttaataaaaa atgattttca aagcgctaaa 18961 aaccgaataa aatagtatat atgcatatga attattggat ttctaggata caataaggat 19021 tagaaatcat ataactatac cttgattagg gggaccaaga aatggctcaa acaggtactg 19081 aacgtgtaaa acgcggaatg gcagaaatgc aaaaaggcgg cgtcatcatg gacgtcatca 19141 atgcggaaca agcgaaaatc gctgaagaag ctggagctgt cgctgtaatg gcgctagaac 19201 gtgtgccagc agatattcgc gcggctggag gagttgcccg tatggctgac cctacaatcg 19261 tggaagaagt aatgaatgca gtatctatcc cggtaatggc aaaagcgcgt atcggacata 19321 ttgttgaagc gcgtgtgctt gaagctatgg gtgttgacta tattgatgaa agtgaagttc 19381 tgacgccggc tgacgaagaa tttcatttaa ataaaaatga atacacagtt ccttttgtct 19441 gtggctgccg tgatcttggt gaagcaacac gccgtattgc ggaaggtgct tctatgcttc 19501 gcacaaaagg tgagcctgga acaggtaata ttgttgaggc tgttcgccat atgcgtaaag 19561 ttaacgctca agtgcgcaaa gtagttgcga tgagtgagga tgagctaatg acagaagcga 19621 aaaacctagg tgctccttac gagcttcttc ttcaaattaa aaaagacggc aagcttcctg 19681 tcgttaactt tgccgctggc ggcgtagcaa ctccagctga tgctgctctc atgatgcagc 19741 ttggtgctga cggagtattt gttggttctg gtatttttaa atcagacaac cctgctaaat 19801 ttgcgaaagc aattgtggaa gcaacaactc actttactga ttacaaatta atcgctgagt 19861 tgtcaaaaga gcttggtact gcaatgaaag ggattgaaat ctcaaactta cttccagaac 19921 agcgtatgca agaacgcggc tggtaagaac ataggagcgc tgctgacatg ttaacaatag 19981 gtgtactagg acttcaagga gcagttagag agcacatcca tgcgattgaa gcatgcggcg 20041 cggctggtct tgtcgtaaaa cgtccggagc agctgaacga agttgacggg ttgattttgc 20101 cgggcggtga gagcacgacg atgcgccgtt tgatcgatac gtatcaattc atggagccgc 20161 ttcgtgaatt cgctgctcag ggcaaaccga tgtttggaac atgtgccgga ttaattatat 20221 tagcaaaaga aattgccggt tcagataatc ctcatttagg tcttctgaat gtggttgtag 20281 aacgtaattc atttggccgg caggttgaca gctttgaagc tgatttaaca attaaaggct 20341 tggacgagcc ttttactggg gtattcatcc gtgctccgca tattttagaa gctggtgaaa 20401 atgttgaagt tctatcggag cataatggtc gtattgtagc cgcgaaacag gggcaattcc 20461 ttggctgctc attccatccg gagctgacag aagatcaccg agtgacgcag ctgtttgttg 20521 aaatggttga ggaatataag caaaaggcac ttgtataaaa cagttgaaag ctgtggaaac 20581 ttatagtaca ttataagcac aaataaagat cgaaaagcgt tgataggaac tagtagggag 20641 cctctctttc taagagagcc gatggttggt gcgaatcggt gaaagatgct gtctgaatcc 20701 atccttgagc gaaatgctga agcgagtagg catttacggg ataaccgtta tgtttgaaag 20761 tggaaaacga gtctttgatt tgttttcaat cagggtggca acgcgagagc tctcgtccct 20821 ttatggggat gagggctctt tttattttcg ataaatcaat aaaaaaagga gtgtttcgca 20881 tgcttgatac gaaaatgctg agagcaaatt ttcaagaaat taaagcaaag cttgtacaca 20941 aaggcgaaga cttaactgat tttgataagt ttgaggcgct ggatgataga cgaagagagc 21001 ttatcggcaa ggttgaagag ttaaaaggaa aacgaaatga agtttctcag caggttgctg 21061 tgctgaagcg tgagaaaaaa gacgcggatc acattattaa agaaatgcgt gaagtcggcg 21121 aggaaattaa aaagctcgat gaagaattac ggacagtgga agctgagctt gatacaatcc 21181 tgctctcaat cccgaatatt ccgcatgagt ctgtacctgt cggtgaaaca gaagacgaca 21241 acgtagaagt gcgtaaatgg ggtgaaaagc cttcatttgc ttatgagccg aagccgcact 21301 gggatattgc ggatgagctg ggtattctgg attttgaacg tgctgccaaa gtaacaggaa 21361 gccgtttcgt gttctataaa ggcttaggtg ctcgtctgga gcgtgcgctt tataacttta 21421 tgcttgatct gcatgtggat gagtataact acactgaagt gatcccgcca tatatggtaa 21481 accgcgcaag catgacggga acggggcagc ttcctaaatt tgaagaggat gcatttaaaa 21541 tcagagaaga agattatttc ttaattccaa cggcggaagt gccgattaca aacatgcatc 21601 gcgatgaaat cctttcaggt gacagcctgc cgatcaacta tgcggcattc agtgcttgct 21661 tccgttctga agctggttca gcaggacgtg acacacgcgg attaattcgt cagcaccaat 21721 ttaataaagt tgagcttgta aagtttgtga agcctgaaga ttcttatgaa gaattagaga 21781 aacttacaaa ccaagcagaa cgggttcttc agctgcttga gcttccatac cgtgtcatga 21841 gcatgtgtac gggtgactta ggctttacgg ctgcgaaaaa atacgatatc gaagtttgga 21901 ttccaagcca agacacatat cgagaaatct cttcttgcag caacttcgaa gcgttccagg 21961 cgagacgtgc gaatattcgt ttcagacgtg aagcgaaagg caagcctgag catgtacaca 22021 cactgaacgg ctcaggactg gcggttggaa gaacagttgc tgctatctta gaaaattatc 22081 agcaggaaga cggaagcgtt gtgattccga aagtgcttcg tccttatatg gggaatagag 22141 aagtaatgaa accgtaaatt atggaaaggc gtgcctgaca aggtgcgcct ttttgcttat 22201 gtaaacacgg cattttcata aaaacaaaaa aagtttttaa aaatgcttga ccacacgaga 22261 acatacgtga tatagttagt cttgtcgata cggaggaata cccaagtccg gctgaaggga 22321 tcggtcttga aaaccgacag gggtgtcaaa gcccgcgggg gttcgaatcc ctcttcctcc 22381 gccatattga ttttaattct aatgaaacac aagcatatat tggagattgt tttgtccgtt 22441 gcattcggtg cggcggattt tttattttaa agaaaaagtg aatctcgact gagattcact 22501 ttttttgatt atcatgaata actgaagcaa tttgatctac aatattttca atcgagtttt 22561 cgtcgttcag aagatcataa tcttcaatgc gaagttttaa aacagggcag gcattaaaac 22621 cgcttatcca gttctcgtag cgtgtatgca tttcttccca ataagaccgg cttgtctgaa 22681 gctccatctc acggccgcgt tgttcaatcc ggtttaaaat gttctccaga tctccttcta 22741 aatagatcaa cacatctgga tgtgggaaat acggtgtcat taccattgct tcgaaaaggc 22801 ttgtgtaagt cttataatca acctttgaca ttgtcccttt atcagcatgc atttttgcga 22861 aaattcctgt atcttcataa atcgaacgat cctgtacaaa acctccgccg gcttcaaaaa 22921 ttgttttctg ttctttgaag cgttcagcta agaagtaaat ttgaaggtga aagctccaac 22981 gttcaaaatc atgatagaac ttttccaaat atggattatg atcgacttcc tccaacgatg 23041 ttttaaatcc aagccgttta gctaaagttt ttgttaaagt cgattttccg acacctactg 23101 ttcctgctac tgtaataatt gaattcttag ggatatgatg ttccttcata cgataagctc 23161 ctttacatgg gcggcaatgc gttcaaagtc gctcttattc aaaacgaaat cctttgaatc 23221 accatctacg gttaacactg taagttcagg gtctgcttcc tgcagctgct tgatggcgac 23281 ttcataatct gaaatcagct gctccaaata gctagtttca atttttttct caaaggggcg 23341 cccgcgtttt tcaatgcggt gtagcaatgt aggcagactg gcctttatgt aaatgatgaa 23401 attcggcttt ggcagatcat ccgttagcag gtgatatatc tttttgtatt tttccagctg 23461 atgtggagac aaggttcgtt ccgcaaaaat cacattttta taaatatgat aatcagctat 23521 tacaggctgt ccctttttta aaaagtgatc actggtgtct tcaagctgtt tgtatctgtg 23581 acaaagaaaa aacatctcga gctggaagct ccattccttt atattgtcat aaaacttatc 23641 aaggtacggg ttatcctcta caatctcatt gatcataggg aatccgaatt tttgtgagag 23701 catcgttgcg agagttgttt ttcctgcccc gataggacct tctattgcaa taaaaggggc 23761 tgtattcatc ggaatcctcc ttatatctga aaaacgtgcg tcagttaccg accttcatat 23821 tgtatcacaa cccttgggtg cccccatgaa aaaaagacgt ttccaaatta tcgaaacgtc 23881 tttttgacaa cattaaattg atcagacagc agcagccagt tttgtggaaa ggaaagaccc 23941 agcttccaat agctgatgcc tcttaaattc agctctttaa tcagattgaa ttttgcttga 24001 atcgagcggg catcctcgaa ccatacctcg tgccttctgt tttctgcatc agtatagcgg 24061 aagaaaggag cttgagcggt ttggtcatac tgaatggaag cattgttctg atcagctatg 24121 acaatggctt gctgagggct tactgctctt gctggagttc cccctgctgt atatggcagc 24181 gtccagtcat atccatataa attctggccc atgacaattt tgttcgcagg catttcagtc 24241 aaagcatatt ctatgacatc acggacaggt ccaattggag aaaccgcttg aggcggtccg 24301 ccgctatagc cccattcata tgtcatgaga acaacaaagt cgacaatttc gccatgtgcc 24361 ctgtaatcat gagcttcata ccacctgccc tgctgtgttg cacttgtttt aggagcaaga 24421 gccgtagaaa tttctaagcc ctctcgatgg aaaagatccc ttgcttcgcg gaggaattga 24481 ttataggcct ctctatcctg gggccgcaaa tattcaaagt cgaaatgaat gtcacggaag 24541 ccatatcttc tggcattctc gactatttca tttagaagcc gtctttttac agtttcgtcg 24601 ttcaaaagga tccggccaag ttcatcgctg aatgcctggt tttctaggtt cgttataatc 24661 atcatcaatg ttgtattttg actttctgta atgctcctta aattcgttaa aggcggtgcg 24721 actaaggttc cgttccgctg tgcctggaag ctgaatgcgc caaggtaagt taagtagggc 24781 gacgcttctc tggccgcctg ctggagattt tcgctgactt gatttcctcg gggctccaaa 24841 taagcatttg attcgatgtc tcgtttagga gctggaggga tgtataaacg gaaaccaatc 24901 tgaagcacgg tatttaactg gatgcggtta acccttgcga gctcggctgc tgttgtattg 24961 aactgccggg cgatggatgt cagggtatca cctcgcttca catcatagaa ctggccagct 25021 attggaatga caatggtttg tccgacaaca aggctgtcgg gattcggtat ttcattcgtt 25081 tcagtgatgt catttgtggt tgttctgtat tgtgaagcga tagcagaaag agtgtcgcct 25141 tgttttacca cataaatttg aatgaaaaac gcctcctttc atatcgctat caatgtatga 25201 aagaaaagcg ctgatcatgt ttatttttct ataatttgtt cttccgtcgt aatttctgcg 25261 aaaagaacat tctccatcat ggttaaggcg aattcgttat cttcgtcact gtttgacgcg 25321 atacagtcct taggaatcgt gatgctgtat tccctcatat aagcgtcatt agcggtaaac 25381 agcacgcata tattgccggc tatacctgtt atgataatat gtctcacctg caactcagta 25441 agaagggtgt gaagtgctgt ttcgtagaaa gcggaatgtt tcggtttgat taaaaaataa 25501 tcagcatcta ccggagctat ctttgtgatg atatccttgc ttctttcatt tgtgcattct 25561 tgctgtatgt ttttaatgtc agcttgccaa agtccataat gatcattgat gtaaataatc 25621 ggccattcat tttgtctcgc gtgctccttt aatgataaaa tatgaggaac gattttttct 25681 gtttttttag cgagggtttc ccccatatcg aattcaaaat tattgatcat gtctacaatg 25741 agaagggctt tatctgcttt ggacaatcga cagtctcctt tccgtttcag ttatagttaa 25801 tatgtagcct ttttaggcaa tgaaaaaact ttgaaaagag agcttatcct tatgacacaa 25861 gatgaacttt atatgaaaga agcaattaaa gaagcgaaaa aggctgaaga gaaaggtgaa 25921 gtgccaatag gtgcggtgct tgtcattaat ggtgaaatta tagcgcgtgc gcataattta 25981 agagagactg aacagcgatc tattgcccat gcagaaatgc ttgtaattga tgaagcgtgt 26041 aaggcactcg gaacatggcg gctggaaggt gcgactcttt atgtgacgct tgagccttgt 26101 ccaatgtgtg ctggtgcagt cgtactttct cgagtggaaa aagtggtttt tggcgcattt 26161 gatccgaaag gcggctgttc aggcacgcta atgaaccttc ttcaggagga acgctttaat 26221 catcaggctg aagtggtgag cggtgtgctt gaggaagaat gcggcggaat gctcagtgcg 26281 tttttcagag aactaagaaa aaagaagaaa gccgccagga aaaacttgtc tgaatagtac 26341 ggttgcaatt tttaggggaa acagatatac ttaagtgtgc atcgtaatag atgcaacata 26401 aaatttgata tttattttgc cgtgctaagc ggggaggtag cggtgccctg tacctgcaat 26461 ccgctctagc agggccgaat cccttctcga ggttcgttta ctttaaggcc tgccttaagt 26521 aagtggtgtt gacgtttggg tcctgcgcaa tgggaattca tgaaccatgt caggtccgga 26581 aggaagcagc attaagtgaa acctctcatg tgccgcaggg ttgcctgggc cgagctaact 26641 gcttaagtaa cgcttagggt agcgaatcga cagaaggtgc acggtaaatc aatcatcaaa 26701 ttttcagact cacctaatat taggtgagtt ttttgttatg taaaaagagc ttttggaatc 26761 gaaacaaggt tcatgtataa tgggaatgat gaataacgga ggagggcaaa cccgtgagtt 26821 accaagcttt atatcgagta ttcaggcctc agcgctttga agatgtggtc ggacaagaac 26881 acattacaaa aacgctgcaa aatgcccttt tgcaaaaaaa gttttctcac gcctatctgt 26941 tttccgggcc tagaggaacc ggaaaaacca gtgcagccaa aatatttgct aaggctgtca 27001 actgtgaaca tgctcctgtt gatgagccat gcaacgaatg tgcggcctgt aaagggataa 27061 caaacgggtc aatatccgat gtcatagaaa ttgacgccgc ttctaataac ggtgttgatg 27121 agattcgtga cattcgcgat aaagtgaagt ttgccccatc ggccgtcaca tataaggtat 27181 atatcataga tgaggtgcat atgctttcta tcggcgcttt taatgcatta ctaaaaacat 27241 tagaagagcc gcctgagcat tgtattttca tattagcaac aactgaaccg cacaaaattc 27301 ctttaaccat tatctctaga tgtcagcgtt ttgactttaa acgaattacc tcccaagcga 27361 ttgtaggccg catgaataaa attgttgatg ctgaacagct gcaagtggag gaaggatcgc 27421 tggaaatcat cgcgagtgct gcagacggag ggatgaggga tgccctgagc cttcttgatc 27481 aggccatatc attcagcggc gatatcctga aagtcgaaga tgcgctttta attacgggtg 27541 ctgtttctca attatatatc gggaagcttg caaaatccct gcatgataaa aacgtttctg 27601 acgcactgga aacattaaat gaattgcttc agcaaggaaa agatccagct aagctgatag 27661 aagatatgat tttctatttc agggacatgc tgctgtacaa aacagcccct ggcttagagg 27721 gagtgcttga gaaagtaaaa gtcgatgaaa cgttccggga actaagtgaa caaattccgg 27781 ctcaggccct atatgaaatg attgatattc tgaacaagag ccatcaggaa atgaaatgga 27841 caaatcatcc gcgtatcttt ttcgaagtgg ccgttgtgaa gatttgccaa acctcacatc 27901 aatctgctgc tgatctcccg gaagtggata tgctgatgaa aaaaatccag cagctcgaac 27961 aggaagtaga gcggctcaaa acaacgggca taaaagcagc tgcggaaagc ccgaaaaaag 28021 aagcgccgcg tgtgccaaag ggcgggaaat ccaattacaa agcgccagta ggcagaattc 28081 atgagatttt gaaggaagcc acaagaccgg atcttgatct gctcagaaac agttggggca 28141 agcttcttgc tcatctcaaa cagcaaaaca aagtatcaca tgccgctttg ctgaatgaca 28201 gtgaacctgt ggctgccgga tcggcggcat ttgttctgaa attcaaatat gaaattcatt 28261 gtaaaatggt cgctgaggat aacaacggag tccggactaa tcttgagcag attttagaat 28321 cgatgctcgg aaaaagaatg gatttgattg gcgttccaga agcacaatgg ggtaaaataa 28381 gagaagaatt tttagaagat catcagcagg aaaatgaagg atcaaatgaa ccggctgaag 28441 aagacccgct tattgccgaa gcgaaaaagc ttgttggagc ggatttaatt gaaataaaag 28501 actaacaaaa tgaaagagag tgaatgctat gcgtggcgga atgggtaata tgcaaaaaat 28561 gatgaaacaa atgcaaaaaa tgcaaaagga catggcgaag gctcaagaag agcttgcaga 28621 aaaggttgtt gaaggaactg caggcggcgg tatggtaaca gtaaaagcaa acggccaaaa 28681 agaaatcctg gatgttatca tcaaagaaga agtcgttgat cctgaagata ttgatatgct 28741 tcaagattta gtgcttgctg caacgaatga agctttgaaa aaagttgacg aaatcacaaa 28801 cgaaacaatg ggtcaattta caaagggaat gaacatgcca ggtttattct agggggataa 28861 aagaacatgc aatatcctga accaatatca aagctgattg acagctttat gaaattgcca 28921 gggatcggac cgaaaacagc ggttcgtctg gctttttttg ttctaggtat gaaagaagat 28981 gtagtattag attttgcgaa agcattagta aatgcgaaac gcaacctgac atattgttca 29041 gtttgcgggc atattacaga tcaggaccct tgctatatat gtgaagatac gcgcagggat 29101 aagtctgtta tctgtgttgt gcaagaccct aaagacgtta tcgctatgga gaaaatgaag 29161 gaatacaacg gacagtatca cgttcttcac ggcgctattt ctccaatgga cggcatcgga 29221 ccggaggata ttaaaatacc agaattgtta aaacgattac aggatgatca agtgacagaa 29281 gtgatcctcg cgacaaaccc taatatagaa ggggaagcaa cagcgatgta tatatcaagg 29341 ctcctcaagc cgtctggtat taagctctcc cgtattgccc acggactgcc cgtcggcggt 29401 gatttggaat atgctgatga ggtcactctt tctaaagcac ttgaaggaag acgtgaattg 29461 taaggaggaa aaagcgatcc atgggttttc ttcgcaagaa aacattaaga agagagtttg 29521 atgaaaaact aaccgagcag ctttttaagc aaaaggaaga gtggaacagg caaaaaaagc 29581 tggttgaaaa aagcttagaa ccgtctgctg aagtgttata cgaactgaaa gtagctgaag 29641 cgaagtattt tttttactta agggaagcga agcagcgaaa tttaaaaatc agccggtgga 29701 agtaagtggt ctaaactcct ggatcttctc ataagcttgt actagaacaa gcgaaggaga 29761 tgagaagatt catggagcct atttttatta ttgggattat tttaggactg gttattcttc 29821 tttttttatc aggttcagca gcgaagcctt taaagtggat tggcatcaca gctgttaaat 29881 ttgtggcagg tgctttgctg ctggtttgtg taaatatgtt tggcggcagt cttggcattc 29941 atgtgccgat taatctggtt acaacagcta tcagcggaat tttaggaata cccggaatag 30001 ctgcgttagt cgtcattaag caatttatca tttaattgat attatgtatt gacttagaca 30061 actgaaggtg ttattctaat atacgtcgct gatgacgaac agcttttttg aaaagaaaat 30121 gctaaaaagt tgttgacagt agcggcggta aatgttatga taataaagtc gcttaaacga 30181 gcggtaaaca aagttctttg aaaactaaac aagacaaaac gtacctgtta attcattttt 30241 ataaatcgca cagcaatgtg cgtagtcagt caaactactt tatcggagag tttgatcctg 30301 gctcaggacg aacgctggcg gcgtgcctaa tacatgcaag tcgagcggac agatgggagc 30361 ttgctccctg atgttagcgg cggacgggtg agtaacacgt gggtaacctg cctgtaagac 30421 tgggataact ccgggaaacc ggggctaata ccggatggtt gtttgaaccg catggttcaa 30481 acataaaagg tggcttcggc taccacttac agatggaccc gcggcgcatt agctagttgg 30541 tgaggtaacg gctcaccaag gcgacgatgc gtagccgacc tgagagggtg atcggccaca 30601 ctgggactga gacacggccc agactcctac gggaggcagc agtagggaat cttccgcaat 30661 ggacgaaagt ctgacggagc aacgccgcgt gagtgatgaa ggttttcgga tcgtaaagct 30721 ctgttgttag ggaagaacaa gtaccgttcg aatagggcgg taccttgacg gtacctaacc 30781 agaaagccac ggctaactac gtgccagcag ccgcggtaat acgtaggtgg caagcgttgt 30841 ccggaattat tgggcgtaaa gggctcgcag gcggtttctt aagtctgatg tgaaagcccc 30901 cggctcaacc ggggagggtc attggaaact ggggaacttg agtgcagaag aggagagtgg 30961 aattccacgt gtagcggtga aatgcgtaga gatgtggagg aacaccagtg gcgaaggcga 31021 ctctctggtc tgtaactgac gctgaggagc gaaagcgtgg ggagcgaaca ggattagata 31081 ccctggtagt ccacgccgta aacgatgagt gctaagtgtt agggggtttc cgccccttag 31141 tgctgcagct aacgcattaa gcactccgcc tggggagtac ggtcgcaaga ctgaaactca 31201 aaggaattga cgggggcccg cacaagcggt ggagcatgtg gtttaattcg aagcaacgcg 31261 aagaacctta ccaggtcttg acatcctctg acaatcctag agataggacg tccccttcgg 31321 gggcagagtg acaggtggtg catggttgtc gtcagctcgt gtcgtgagat gttgggttaa 31381 gtcccgcaac gagcgcaacc cttgatctta gttgccagca ttcagttggg cactctaagg 31441 tgactgccgg tgacaaaccg gaggaaggtg gggatgacgt caaatcatca tgccccttat 31501 gacctgggct acacacgtgc tacaatggac agaacaaagg gcagcgaaac cgcgaggtta 31561 agccaatccc acaaatctgt tctcagttcg gatcgcagtc tgcaactcga ctgcgtgaag 31621 ctggaatcgc tagtaatcgc ggatcagcat gccgcggtga atacgttccc gggccttgta 31681 cacaccgccc gtcacaccac gagagtttgt aacacccgaa gtcggtgagg taacctttta 31741 ggagccagcc gccgaaggtg ggacagatga ttggggtgaa gtcgtaacaa ggtagccgta 31801 tcggaaggtg cggctggatc acctcctttc taaggatatt ttacggaata taagaccttg 31861 ggtcttataa acagaacgtt ccctgtcttg tttagttttg aaggaacttt gttccttgaa 31921 taagttaaga tgggcctgta gctcagctgg ttagagcgca cgcctgataa gcgtgaggtc 31981 ggtggttcga gtccactcag gcccaccatc ttatataacg gggccttagc tcagctggga 32041 gagcgcctgc tttgcacgca ggaggtcagc ggttcgatcc cgctaggctc caccaacgtg 32101 ttctttgaaa actagataac agtagacatc acattcaatt agtaacacaa gatatcacat 32161 agtgattctt tttaacggtt aagttagaaa gggcgcacgg tggatgcctt ggcactagga 32221 gccgatgaag gacgggacga acaccgatat gcttcgggga gctgtaagca agctttgatc 32281 cggagatttc cgaatgggga aacccaccac tcgtaatgga gtggtatcca tatctgaatt 32341 cataggatat gagaaggcag acccggggaa ctgaaacatc taagtacccg gaggaagaga 32401 aagcaaatgc gattccctga gtagcggcga gcgaaacggg attagcccaa accaagaggc 32461 ttgcctcttg gggttgtagg acactctgta cggagttaca aaggaacgag gtagatgaag 32521 aggtctggaa aggcccgcca taggaggtaa cagccctgta gtcaaaactt cgttctctcc 32581 tgagtggatc ctgagtacgg cggaacacgt gaaattccgt cggaatccgg gaggaccatc 32641 tcccaaggct aaatactccc tagtgaccga tagtgaacca gtaccgtgag ggaaaggtga 32701 aaagcacccc ggaaggggag tgaaagagat cctgaaaccg tgtgcctaca agtagtcaga 32761 gcccgttaac gggtgatggc gtgccttttg tagaatgaac cggcgagtta cgatcccgtg 32821 caaggttaag cagaagatgc ggagccgcag cgaaagcgag tctgaatagg gcgcatgagt 32881 acgtggtcgt agacccgaaa ccaggtgatc tacccatgtc cagggtgaag ttcaggtaac 32941 actgaatgga ggcccgaacc cacgcacgtt gaaaagtgcg gggatgaggt gtgggtaggg 33001 gtgaaatgcc aatcgaacct ggagatagct ggttctctcc gaaatagctt tagggctagc 33061 ctcaaggtaa gagtcttgga ggtagagcac tgattggact aggggcccct accgggttac 33121 cgaattcagt caaactccga atgccaatga cttatccttg ggagtcagac tgcgagtgat 33181 aagatccgta gtcgaaaggg aaacagccca gaccgccagc taaggtccca aagtatacgt 33241 taagtggaaa aggatgtgga gttgcttaga caaccaggat gttggcttag aagcagccac 33301 catttaaaga gtgcgtaata gctcactggt cgagtgactc tgcgccgaaa atgtaccggg 33361 gctaaacgta tcaccgaagc tgcggactgt tcttcgaaca gtggtaggag agcgttctaa 33421 gggctgtgaa gccagaccgg aaggactggt ggagcgctta gaagtgagaa tgccggtatg 33481 agtagcgaaa gaggggtgag aatcccctcc accgaatgcc taaggtttcc tgaggaaggc 33541 tcgtccgctc agggttagtc gggacctaag ccgaggccga aaggcgtagg cgatggacaa 33601 caggttgata ttcctgtacc acctcctcac catttgagca atggggggac gcaggaggat 33661 agggtaagcg cggtattgga tatccgcgtc caagcagtta ggctgggaaa taggcaaatc 33721 cgtttcccat aaggctgagc tgtgatggcg agcgaaatat agtagcgaag ttcctgattc 33781 cacactgcca agaaaagcct ctagcgaggt gagaggtgcc cgtaccgcaa accgacacag 33841 gtaggcgagg agagaatcct aaggtgatcg agagaactct cgttaaggaa ctcggcaaaa 33901 tgaccccgta acttcgggag aaggggtgct ctgttagggt gcaagcccga gagagccgca 33961 gtgaataggc ccaggcgact gtttagcaaa aacacaggtc tctgcgaagc cgtaaggcga 34021 agtatagggg ctgacgcctg cccggtgctg gaaggttaag aggagcgctt agcgtaagcg 34081 aaggtgcgaa ttgaagcccc agtaaacggc ggccgtaact ataacggtcc taaggtagcg 34141 aaattccttg tcgggtaagt tccgacccgc acgaaaggcg caacgatctg ggcactgtct 34201 caacgagaga ctcggtgaaa ttatagtacc tgtgaagatg caggttaccc gcgacaggac 34261 ggaaagaccc cgtggagctt tactgcagcc tgatattgaa tgttggtaca gcttgtacag 34321 gataggtagg agccttggaa accggagcgc cagcttcggt ggaggcatcg gtgggatact 34381 accctggctg tattgacctt ctaacccgcc gcccttatcg ggcggggaga cagtgtcagg 34441 tgggcagttt gactggggcg gtcgcctcct aaaaggtaac ggaggcgccc aaaggttccc 34501 tcagaatggt tggaaatcat tcgcagagtg taaaggcaca agggagcttg actgcgagac 34561 ctacaagtcg agcagggacg aaagtcgggc ttagtgatcc ggtggttccg catggaaggg 34621 ccatcgctca acggataaaa gctaccccgg ggataacagg cttatctccc ccaagagtcc 34681 acatcgacgg ggaggtttgg cacctcgatg tcggctcatc gcatcctggg gctgtagtca 34741 gtcccaaggg ttgggctgtt cgcccattaa agcggtacgc gagctgggtt cagaacgtcg 34801 tgagacagtt cggtccctat ccgtcgcggg cgcaggaaat ttgagaggag ctgtccttag 34861 tacgagagga ccgggatgga cgcaccgctg gtgtaccagt tgttctgcca agggcatcgc 34921 tgggtagcta tgtgcggacg ggataagtgc tgaaagcatc taagcatgaa gcccccctca 34981 agatgagatt tcccattccg caaggaagta agatccctga aagatgatca ggttgatagg 35041 tctgaggtgg aagtgtggcg acacatggag ctgacagata ctaatcgatc gaggacttaa 35101 ccacattttg aatgatgtca cacctgttat ctagttttga gagaacacct ctctaaaggc 35161 ggaaggtaag gaaactccgc taagggctct cacatcctgt gagaaacgcc cagtaccttc 35221 atcctgaagg catttgtttg gtggcgatag cgaagaggtc acacccgttc ccataccgaa 35281 cacggaagtt aagctcttca gcgccgatgg tagtcggggg tttccccctg tgagagtagg 35341 acgccgccaa gcaagcttaa acccagctta atgagctggg ttttttgttt actcaagatc 35401 gagaaaatca aacaaataca aacaccgagg gcttatatag cccatatact gatttaaagt 35461 ttcaaaaagg tctaaatagt gtatacaata tccgttttaa ggggaggcta actgtacgga 35521 ggtggagaag atggacgaaa cagttaaact taatcataca tgtgtgattt gtgatcaaga 35581 gaagaataga ggcattcatc tttatacgaa attcatatgc ttagattgtg agagaaaagt 35641 aatttctaca tcaacttctg atcctgacta tgcgttttac gtaaaaaaac taaagagcat 35701 tcatacaccg ccattatatt catagacctg aaaaggtctt tttttgtact cttaataata 35761 aaaagaagat gaaacttgtt taaggattga acgtagtaga taataatatt aaaactgagt 35821 atagacacag gagtcgatta tctcatgcag agattttttc actttttggt gtggagttta 35881 actagcagtg cgacttttgt tttcattgga atattgagct tttttggttt aaaccagtcg 35941 atttttttat ctattgttta tgggcttgct tctggagcag ccgtatatat agctggcatc 36001 tggaatgcaa gacggttatt tcttaaaaag catgaattga caggaagaga gtatgcttac 36061 attaagaaaa acttagagga agcaaggcag aaaatggtcc gtcttaggaa agccttgttt 36121 caggctaaaa gcattcaaat gtttaagcaa aatgcagaaa tgctaaggat tgtgagaagg 36181 atttatctcc tcaccaaaaa agagccaaag cggttttatc aggcagaacg atttttttat 36241 caaactctcg attcggttgt tgaattgaca gagaagtatg cttttctatc atctcaccca 36301 aaaaaaagca aagaactgtc gatgtcgtta agtgagacac gcatcactct tactgaattg 36361 accaagcgtt tagaggaaga tttaactcaa gcaatgggtg atgaaattga cgagttgcag 36421 tttgaattag acgcagcaaa acattcatta aagaaataag ggaagagggt aagagcgatg 36481 aaccgagacc aaagcgacct tcatatagat gaattattgg cagatccttt tggtggtaac 36541 atagagatac caggttcgga ggctgtaaaa gcagagaaag agcaagtacg gcttgttgat 36601 gttcttcctg aggaaaacaa ggaaaaagca attcagcttg ctggacagat tgatcataaa 36661 aatatgcaaa gcattgtctt atacggttca caagctcaat ctaaactgct gaacttttct 36721 catgatatga ttaatcatgt tcaaaagaag gatgtcgggg agattggcga aatacttgga 36781 gagctgatga aaaagctgga gcaagtaaat cctgatgatc tccaatctaa gaaaaagggt 36841 tttttggcac gcatgtttgg aagagtatca agttctcttc aagaggtgct gtctaaatac 36901 caaaagacca gtgtgcagat agacagaatc agcttgaagc tggagcactc taaaaatgct 36961 ttaatcagtg acaacaagct gttagagcag ttatatgaaa aaaataaaga atatttcgca 37021 gcgctgaatg tttatattgc tgcaggagaa ctgaagctgg aggaattaaa aacaaaaacg 37081 attcctgaac tgaagcaaca ggctgaatcg agtgatcata accaaatggc cgttcaagag 37141 gtgaatgatt taattcaatt tgctgaccgg ttagataaaa gggtgcatga tttgctgctg 37201 agcaggcaaa ttacaatcca aagtgcaccg caaatcaggc tgattcaaaa tacaaaccaa 37261 gcgttagctg aaaagattca gtcatccatt gtgacagcga ttccgttatg gaaaaatcaa 37321 gttgccattg cactgacgct tttaaggcag cgcaatgcag tggatgcaca gcagaaagta 37381 tctgatacaa ccaatgagct tttgctgaaa aatgcggagc ttttaaaaac caatacaatt 37441 gaaactgcac gggcaaatga aagaggcctt gttgatatag ataccttgaa gaaggtgcag 37501 gaaagcttaa taagcacgct tgaagaaaca ctgactatac aagaagaagg acgaatcaaa 37561 cgccgtcagg cagaagaaga gctcatgatg atggaaggcg acctgaagca aaagctgatt 37621 acaataaagg aaagatgatt accagtaagt ctggctttaa gttctgtcag aggcacgata 37681 taataaggtg taagaagaca cattcaaagg attgttttca tgaacacacc tttatataaa 37741 gcattaattc aacatgcgag aagaaattct cattcatttc atgttccggg acatcacaat 37801 ggagatgtct tttttgatga cgctaagtca atattcgatc cgcttctcac cattgatgta 37861 actgaactgg caggactgga tgatctccat catccttctg gggtgattaa ggaagctcag 37921 gagcttgcca gtcaattata tggatcggcg gaaagttttt ttctggtaaa tggtacgact 37981 gtcggaaact tagcgatgat tttatctgtt tgtgaacctg gtgatacaat tctggttcaa 38041 agaaactgtc ataaatctgt atttcatgct gttgatttgt ccggtgctga gccggtttat 38101 cttgcacctg acgttgattc agcgatgcat gtgcctacgc atgttccgct tggaacaatt 38161 aaagaggccc tggaagcata tccagatgcg aaaggcttgg tactgaccaa tccgacatat 38221 tacggacata gtgctgattt gactgagatc attactgaag cccatcatta cgggattcct 38281 gttttggtcg atgaagcgca tggcgcacat tttattttag gtgagccttt tccggtctca 38341 gctttaaaaa tgggggcaga tattgttgtt cagtcggccc acaaaacgtt gccagccatg 38401 acgatgggtt cttatttgca tctcaacagc agctgcagga ttaacaggga tcgggtggca 38461 gagtatttaa accgattaca aagcagcagc ccgtcttatc cgattatggc ttcgttagat 38521 attgcccgcg cttatgtaca gcatattata gaagaacaaa agctttctga cattctgcag 38581 cggatagaaa cacttaaaca aacgtttgat tcacttacaa atgcagaagc tgttaaccct 38641 gctaatccac tgatcatcac ggatccgcta aagctcacaa ttcgttcaaa acgcgggcat 38701 tctggctata cgctgcaaag cattttagag cgtgccaaca tattcactga gcttgctgat 38761 gaaaatcaag ttctgctcgt tctcccattg ggaggaaaac ggagaataaa cgctgaaatc 38821 attagaagca tcgatgaaga gattgagaaa acgcctccgg atcagacgtt tgtttctgca 38881 gaatggggtg tgcagcctgt tactgtcttg ccttatccaa aaaaggtctt acattcgttt 38941 aagaaagaat atgtgagctt tgaggaagca gctggccggc ttaatgcaga agatatcatc 39001 ccttatcctc cgggtatccc gatgattatg gcgggagaaa gaataacaaa agaaagtgtg 39061 caaaagctca gccgcttgat cagcatgaaa acgcatgttc aagggaatat gaaaatcaaa 39121 gagaaacaac tacttgttta tatagaagag gagaaatcat gagcggttta tttattacat 39181 tcgaaggtcc tgaaggtgca gggaaaacga ctgttctgca ggagatcaaa aacatactga 39241 cagcagaagg ccttcaggtt atggcaactc gagagccagg cggaatagat attgcagaac 39301 aaattagaga ggttattctg aatgagaaca atatattaat ggacccaaaa acagaagctc 39361 tcttatatgc ggctgcaaga cgccagcatt tagttgaaaa agtaaaacct gctttagaac 39421 aggggtttat cgttctttgc gacagattca tagacagttc tcttgcgtat caaggatatg 39481 caagagggct tggaattgat gaggttctgt ccattaatga atttgccatt ggagatatga 39541 tgccccatgt aacggtttat ttttcaattg atccggaaga aggactgaag cgtatttacg 39601 caaacggctc acgggagaaa aacaggctcg atttagaaaa actggacttt catacaaaag 39661 tacaagaagg ttatcaagag ctgatgaagc gatttccgga aagatttcat tcagttgatg 39721 ccgggcaatc caaagacctc gtcgttcagg atgttctaaa ggtgatcgat gaagcgttga 39781 aaaaaattca attgtgacct gtttcccaat agttgatata ataatgtaaa cgagatcacg 39841 ttgtttccaa tctaaaggag gccttcacag atgaaattga tagtggcagt tgtacaagat 39901 caggacagca acagactttt gaaaacctta acggatcaca acttcagagt cacaaagctt 39961 gcaacgacag gaggatttct taaatcaggc aatacaacgt ttatgatcgg tgtcgaggat 40021 atacgcgtca ataaagcgtt gagtctcatt aaagaaaacg ggcagaaacg tgatcagatg 40081 attgcccctg tatctccaat gggtggaaat gctgattcct atgtccctta tccagtcgaa 40141 gttgaagttg gcggagcgac agtatttgtc cttccagtcg atgaatttca tcaattttaa 40201 ggatctgaaa ctgtgaaaat taataaagat atacgtacat ttatagataa taagcagatt 40261 ccctctgtga aaacatctga gatcacagca tcgtttaaaa catcaatgga aaaccaaagc 40321 agcaaaatga agcttgatca gcttaccagg ctgttatctg atatagaagc atttggaaaa 40381 aggctaacga aatctcggaa ttttaaagac ttagcgagat ttaaaggact tgtgaaacgt 40441 tttgtcaaag aagctgtgga cagcggtctt tcacatgaaa catcgaaaag ctttgacctt 40501 tacgggaaca gcagaacgct gggacttgtg aaagaaatag atgacaaatt gatacagctt 40561 acggaagaga tgatggatca ggaaaaaccg gcaattgatt tgctggagcg tattggcgaa 40621 ataaaaggtt tattaattaa cctttacaca tagagagtga tacaatggca atatcctgga 40681 aggaaatgaa cgagcttcag cccagagtga tgaagctttt atataatagt attgagaagg 40741 acagactatc acacgcttat ttgtttgagg ggaaaaaagg aacaggcaag cttgatgccg 40801 cgctgcttct tgcaaaaagc ttcttttgtc tggagggtgg cgcggagcct tgtgagagct 40861 gccgaaactg taaacggata gagtcaggga accatcctga tctccatctt gttcagcctg 40921 atggcttatc aatcaaaaag gcgcaaattc aagcgctcca agaagagttt tctaagacag 40981 gacttgaatc gcataaaaag ctgtatatta tttcgcacgc agatcaaatg acagcaaatg 41041 cggcgaacag cctgctgaaa tttttagaag aaccgaacaa agacacaatg gccgtcctca 41101 tcactgagca gccccaaagg ttattggata ccatcatttc aagatgccaa acccttcctt 41161 ttcagccttt gcagccgaaa gcaattgaag acagactgat cgaacaggac gtctcgcctc 41221 atatggcaag gcttctggcc aacatgacta ataatgtagc agaagcagtc gaattaagtc 41281 gaaatgatga gtttgcagag tctagagcga aagtgataaa attgtatgaa gtcctacacc 41341 agcggaaagg acatgctttt ttctttattc aagatcaatg gatgcccttt ttcaaagaaa 41401 aaacccatca agaaatgggt cttgatatgc tcttattgat atatcgtgat gtgttgtcca 41461 tccaaatagg aaatgaagat aaattgattt atcaagactt attccaatca ataaaacagc 41521 atgcgctaca atcaacacaa caaagcgtta cgaatcagat acttgctgtt ttagaagcaa 41581 agaaacggct tcattccaat gtgaatgtac aaggattaat ggagcacttg gtgttaatgt 41641 tgcaggaggg ataagcttgt acaatgtaat tggtgtccgc tttaagaaag cgggtaaaat 41701 atattatttt gatccgaatg gatttcatat agaacatgac agctgcgtaa ttgtagaaac 41761 tgtcagaggc gttgagtacg gccaggtcgt aattgcaaat aaacaggtgg atgagcatga 41821 tgtggtgctt ccccttcgaa aagtgatacg tgtggcagac gatcgcgatc ttctcattgt 41881 agaagaaaat aaacaggaag cactatcagc atttgatatc tgccaaaaga aagtgattga 41941 gcatggcttg gatatgaagc tggtcgatgt tgaattcacg tttgatcgca ataaagtcat 42001 tttttacttc actgctgacg gccgagtcga ctttagagag cttgtaaagg atttggcttc 42061 tatctttaag acaagaattg agctgcgcca aatcggagtg agggatgagg caaaaatgct 42121 cggaggaatc ggtccttgcg gaagaatgct ttgctgttca acgtttcttg gagattttga 42181 acccgtttcc attaaaatgg ccaaggatca gaacttgtct ttaaatccta cgaagatttc 42241 gggtctttgc ggacgattga tgtgctgtct aaaatatgag aacgatgagt atgagacggc 42301 aaaagaacag cttccggata taggagaaat gattacgaca gcaaacggtc ccgcgaaggt 42361 cgtcggacta aatattctgg aacgggtgct tcaggtggaa ctgataaacc gtgaaaaagt 42421 gatagaatat acttgggaag agctcttgga agagggcgtc gtatccgcac aaaccacaga 42481 ttaacgaggt gtggaacctt ggataaaaaa gagttatttg atacagtcat taacttagaa 42541 gaacaaattg gctcactgta ccggcagctg ggggatttga agcagcatat cggtgagatg 42601 attgaggaaa atcatcattt acagcttgaa aacaagcatt tgcgcaaacg gctggacgat 42661 acgacgcagc agattgaaaa gttcaaagct gataaaaaag aatcaaaaac acagaagaca 42721 gagcaaactg atatagggga aggatatgat aatctggcac gtctgtatca agaaggattt 42781 catatctgca atgtccacta tggaagtgtt cgaaaagagg attgtctttt ctgtctgtca 42841 ttcttaaata aaaaataggg aaaaggcttc cgcataagac gggagccttt ttcaaaggta 42901 ctgaaaggat aagaagatgg tttcattaca tgatgatgaa agattagatt atttgctggc 42961 agaggacatg aaaatcatac aaagcccaac agtgtttgct ttttcgttgg acgctgtgct 43021 tctgtccaaa tttgcgtacg ttccgattca aaaagggaaa attgttgatt tatgcaccgg 43081 caatggtatt gtgccgctgc tgctcagtac aagatcaaaa gcagacattc tgggagtcga 43141 aattcaagaa agactgcatg atatggctgt tcgcagcgtg gagtataata agttggacga 43201 tcagatccag atcatacatg atgacctgaa aaacatgccg gagaaacttg gacataatcg 43261 atatgatgtt gtcacctgca atccgccgta ttttaaaacg ccgaaacaaa ctgaacaaaa 43321 catgaacgag catctccgaa tcgcaagaca tgaaatccac tgcacgctgg aggatgtcat 43381 ttcagtcagc agcaagctgc tcaagcaagg gggaaaagca gctcttgttc accggccggg 43441 aaggcttctg gagatttttg aactgatgaa ggcttatcaa atcgagccga aacgtgtaca 43501 atttgtctat ccgaagcaag ggaaagaagc caataccatt ttggttgaag gtatcaaagg 43561 cgggcgcccg gatttgaaaa ttcttcctcc cttattcgta tatgatgaac aaaatgaata 43621 tacaaaagaa atcaggacca ttttatatgg agacaaataa ccatttcttc tacgtcgtga 43681 aatgtaagga caatagctgg tatgccgggt ataccaacga tctgcataaa cgagtgaaaa 43741 cgcacaatga tggaaagggc gcaaagtaca caaaagtaag acgtccggtt gaattaattt 43801 ttgccgagag cttttcaaca aagcgggaag ctatgcaggc ggaatattat ttcaaaaaac 43861 taactcggaa gaaaaaagag ctttatatag aagaaaagcg gaacagcaag gaggctgtat 43921 atgttaaggc gccaaatgag ctttaatgga aagtcggaca tggggattct ttacttggtc 43981 ccaaccccaa tcggaaattt agaggatatg acattccggg cgatcgacac gctgaaatca 44041 gtggatgcga ttgctgcgga agatacgagg caaacgaaaa agctttgtca tgtatatgaa 44101 attgaaacac cgctcgtcag ctatcacgaa cacaataaag aaagcagtgg gcacaaaatt 44161 attgaatggc tgaaatcggg aaaaaacatt gctcttgtca gtgatgccgg tctgccgacg 44221 atttctgatc ccggagcgga aattgtaaag gattttacgg atataggcgg ttatgttgtt 44281 ccgttgccgg gagcaaatgc tgcattaaca gctcttattg cttcaggtat tgtaccgcag 44341 ccttttttct tttacggttt tctcaacaga cagaaaaaag aaaagaagaa ggagcttgaa 44401 gcccttaaaa aacggcagga aacgatcatt ttttatgaag cgccccacag attgaaggaa 44461 accttgtcag cgatggcaga gatattagga gatcgggaaa ttgctgtaac acgtgaactc 44521 actaagaaat atgaagagtt tatccgagga accatatctg aggtcattgg atgggcaaac 44581 gaggatcaga tacgcggcga gttttgtctt gtcgtagaag gaagtaataa tgaagaggta 44641 gatgaggaag aacaatggtg ggaaaccctc actgcgaaag aacatgtcga gcattacatt 44701 tcgaaaggcg ctacgtctaa agaagctatt aaaaaagcag cagtcgatcg caatgtacca 44761 aagcgtgaag tgtacgatgc ttaccatatt aagcaataaa aaaacgttct tgtgtcataa 44821 caagaacgtt ttttgtacaa gaaatgatta tttaaggttt tgaagctggt tttggatttc 44881 gctgatgatt tgctcagcgc cttctttact aagaaccaat ttaccgcctg caagtttaag 44941 gttatcatca gaaacttcac cagttacttg gcaagtcatg tttggtttat attttttaag 45001 gatgattttt tcatcatcaa catagatttc aagagcatct ttttctgcga ttccaagagt 45061 acgacgcagt tcgataggaa taactacacg tcctaattca tcaactttac gtacaatacc 45121 agtagatttc ataaacattc tcctcccaag agatacttat ttgtttaaat tatatttttc 45181 ttcgtcatta ttcgacaaaa tccttacctt catagcataa caaggtttcc aataatcgtc 45241 aatcattttg tttactattg attgtaagaa ttagttctta tagtcagtaa tgtcttggaa 45301 actaccgaaa taacagcatt ttataaatat ttaataaagc tattatccta ctaaaaatcc 45361 ttttaaatca agactttcga accaaagttt tttatttcat ttgattatat acgacaaaat 45421 tcgacacgaa cagacttttt ttattttcat taaagatttt taattttaat tattcttttt 45481 cagggcgtat gtatatattc ttgatcttaa aggctaagat ggtatcatag ataaaggata 45541 aatataaata atattcatat atgatttgca cttatcgccg ctctcgtcct ttgggcggga 45601 gctttttgac attctgatta ggaggtttca agatgccgca agaaaacaat acattttaca 45661 ttacaacacc gatttattat ccgagcggaa aattacatat cggccatgca tatacgacag 45721 tcgcaggaga tgcaatggca cgttacaaaa gattaaaagg gttcgatgtt cgctatttaa 45781 cgggaacgga cgagcatgga caaaagatcc agcaaaaagc tgaacaggaa aacattacac 45841 ctcaggagta tgtggatcgc gcagcggcag atattcaaaa actgtggaag cagcttgaaa 45901 tctcaaacga cgactttatc cgcacgacag aaaaacggca taaagttgtc attgaaaaag 45961 tgtttcaaaa gcttcttgat aacggggaca tctatcttga tgagtatgaa ggctggtaca 46021 gcatccctga tgaaacgttc tacacggaaa ctcagctcgt tgatattgag cggaatgaaa 46081 agggagaggt catcggcgga aaaagccctg acagcggtca cccagttgaa ttgatcaaag 46141 aggaatctta tttcttccgc atggggaaat acgcggatcg tcttctgaaa tactatgaag 46201 aaaacccgac attcattcag ccagaatcac gcaaaaacga aatgattaat aactttatca 46261 aacctggact tgaggatttg gcagtatcac gtaccacttt tgattggggc gtgaaggtgc 46321 cggaaaatcc aaagcatgtt gtatatgttt ggattgacgc actatttaac tatttaacgg 46381 cactcggtta tgatacagaa aatgatgagc tttatcaaaa atattggcct gccgatgttc 46441 atttagtcgg taaggagatt gtacgattcc atactattta ctggccaatt atgctgatgg 46501 cgctggatct tccgctgcca aagcaagtat tcgcgcatgg ctggcttttg atgaaagacg 46561 gaaaaatgtc gaaatcaaaa ggaaacgttg tagatccggt tacattaatt gaacgctatg 46621 gtttagacga acttcgctat tacttgcttc gcgaagtgcc gttcggatca gacggtgttt 46681 tcacgccgga aggatttgtt gagcgaatca actatgattt agcgaatgat ttaggaaatc 46741 tattgaatcg tactgttgcg atgattaata agtattttga cggacaaatc ggttcttaca 46801 aaggtgctgt tacggaattt gaccatacgc tcacttctgt tgctgaagaa acagtgaaag 46861 cttatgagaa agcaatggaa aatatggagt tctcggtagc actttcgact ttatggcagc 46921 tcatcagccg cacaaacaaa tacattgatg agacagctcc atgggtgctt gcgaaagatc 46981 cggcaaaaga agaagaattg cgatcagtta tgtatcatct cgctgaatca ttgcgtattt 47041 cagcggtact gcttcagcca ttcttaacaa aaacacctga aaaaatgttc gagcagctgg 47101 gcattactga tgaatcttta aaagcttggg acagcattac agctttcggc cagctgaaag 47161 atacaaaagt acaaaaaggc gagccattgt tccctcgttt agaggcagaa gaagaaattg 47221 cttacatcaa agggaaaatg caaggttcag caccagcgaa agaagaaaca aaagaagaag 47281 agcctcaaga ggtcgatcgt ttacctgaaa ttacgattga tcaatttatg gatgtagagc 47341 ttcgcgtagc tgaggtcatt gaggcagagc cagtgaaaaa agcagaccgt ttattgaagc 47401 tgcagcttga tcttggtttt gaaaagcgcc aagtggtatc cggcattgcg aagcattata 47461 cgcctgaaga gcttgttgga aaaaaactcg tttgtgtaac aaatctaaaa ccggttaaac 47521 tcagaggaga gctttctcaa ggtatgatcc ttgcaggaga agcagacggc gttttaaagg 47581 tcgtatctat cgatcagtcg ttaccaaaag gcacaagaat taaataatga taaacaaaag 47641 gtgtttcacg tgtaacaatt cgtcgaacac cttttgtgtt tcgacaagaa aggagttttt 47701 cacttatgtt gtttgacact cacgcgcatt taaatgcaga acaatatgat actgatcttg 47761 aagaggttat tgaacgggca aaagctgaaa aagttgaacg aattgtcgta gttggttttg 47821 accgtccgac gattacccgt gcgatggaaa tgattgagga atatgatttt atttatgcag 47881 ccattggctg gcaccctgtt gacgctattg acatgacaga ggaagactta gcgtggatta 47941 aagagctttc tgctcatgag aaagtggtag cgatagggga aatgggactg gattatcatt 48001 gggataaatc acctaaagat attcaaaaag aggtgtttag aaatcaaatc gccttagcga 48061 aagaggtcaa tttgcctatt atcattcata accgtgatgc aacggaggat gtcgtgacca 48121 ttttgaaaga ggaaggcgca gaagctgtgg gcggaatcat gcactgcttt acaggaagtg 48181 cggaagtggc aagagaatgc atgaaaatga atttttattt atcatttggg ggaccggtga 48241 catttaaaaa tgcgaagaaa ccgaaggaag tagtgaagga aattcccaat gaccggctgc 48301 tgattgaaac ggactgcccg tttctcacac cgcacccttt ccgcgggaaa agaaatgagc 48361 caagctatgt gaaatatgtg gcagaacaaa tcgccgaatt aaaagaaatg acctttgaag 48421 agattgcttc catcacgact gaaaatgcga aaagactttt ccgtataaac tgacaaaaaa 48481 cgctagcggg ttttgtaaga gcttgtccct tacagcgttt ttctataaaa gttctacatg 48541 ctttcttctc ctcataggat aggtttgtcg acaagtcttt cttccgtttc tcagtgtatt 48601 tcaggataat gaagaggaca ctgagctttt gggagaaaga gaagggaggg ttgacagcct 48661 tttagatact ctatataatc tctccgagga gaaggaggcg tttttcatca cacaaaaaat 48721 gaaaaagctg ttttccgtaa agcttagcaa aagcaaagtc attctggttg ctgcttgttt 48781 gcttttggca ggaagcggga ctgcgtacgc ggctcatgag ctgacgaaac aatcagtctc 48841 agtttctatc aatggcaaaa agaaacatat acgcacacat gcaaatacag tcggtgatct 48901 tttggagacg cttgatataa agacaagaga cgaagacaag atcacacctg ctaaacagac 48961 aaagataaca gcagacatgg acgttgtgta tgaggctgca aaacctgtga agcttacaat 49021 aaacggggaa gaaaagacgt tatggtcaac agcaaaaacg gtcggtgcat tactggacga 49081 acaagatgtt gatgtgaaag aacaagatca aattgatccc gcaatagata cagatatttc 49141 gaaagacatg aagattaaca tagagcccgc atttcaggtt actgtgaatg atgcagggaa 49201 acaaaagaag atctggacga cttcgactac ggtcgctgac tttttaaaac agcaaaagat 49261 gaacataaaa gacgaagata aaatcaagcc tgcgttagat gcaaagctga cgaaaggaaa 49321 ggctgatatt acaattactc gtatcgaaaa ggtcaccgat gtagttgaag agaagattgc 49381 gttcgatgtg aaaaagcaag aagacgcttc tcttgaaaaa gggaaagaaa aggtcgtcca 49441 aaaaggaaaa gaaggcaagc taaaaaaaca tttcgaagtc gttaaagaaa acggtaaaga 49501 agtgtccaga gagcttgtaa aagaagaaac agctgaacaa agcaaagata aagtgattgc 49561 tgtcggcaca aagcaaagca gtccaaaatt tgaaacggtc agtgcttcag gtgattcaaa 49621 aacagttgtg tcccgcagca atgaatcaac aggcaaagtc atgactgtat catctacggc 49681 ttatacggca agctgcagcg gttgttcagg acatacagcg acaggcgtca atttaaaaaa 49741 taatccgaat gccaaagtca tcgctgtgga tccaaatgtc attccgctag gctccaaagt 49801 ccacgtggaa ggctatggat atgccattgc tgcagatacc ggttcagcga ttaaagggaa 49861 caagatagac gtctttttcc cagagaaatc atcggcgtac cgatggggaa ataaaacagt 49921 caaaattaaa atcttaaatt agtatatact tatgtattca gagggttttg cgccctctgt 49981 ttttttcgtt ataatagaca aagtgcattt tctgcttatt agacgctcga tataagaaaa 50041 agtttcatga atatacaaaa gtttttattt tgtcttggag gaaataatga aaattaaaga 50101 gatcattgtg gtcgaggggc gtgacgatac ggcccgcatc aaattggctg ttgatgcaga 50161 cacaattgaa acaaatggtt cagccatcga tgatcatgtg attgaccaaa tccgtttggc 50221 ccagaagacg agaggcgtca ttattttaac ggatccggac tttccgggag agaagattcg 50281 caaaaccatc tcagaggctg tacccggctg taagcatgca tttttgccaa aacatcttgc 50341 caaacctaaa aacaagcggg gaattggtgt ggagcatgca tcggttgaaa gcattagggc 50401 atgtttagaa aatgtgcatg aggagatgga agcgcagccg agtgacattt cagctgagga 50461 tttgattcat gccggactaa taggcgggcc tgcggccaaa tgccgccggg aacgactggg 50521 tgatctgttg aaaatcggct atacaaatgg caaacagctt caaaaacggc tgcaaatgtt 50581 tcaaattaaa aaaagtgatt ttatgagtgc gctcgatacc gttatgcggg aggaacagaa 50641 tgaataaaga tattgcgaca ccgattagaa cgaaagagat actgaagaaa tacggttttt 50701 cttttaaaaa gagcttagga cagaatttct taattgatac gaacatttta aacagaattg 50761 ttgatcacgc ggaagtgacg gagaaaacag gtgtcattga aatcggcccg ggaatcgggg 50821 ctttaaccga acagcttgcc aagcgggcga aaaaggtcgt ggcatttgag attgaccagc 50881 gattattgcc gattctgaag gatacactgt caccttacga aaatgtcact gtcattcatc 50941 aggacgtgtt aaaggctgat gtcaaatcag tcattgaaga acaatttcaa gattgtgatg 51001 agatcatggt agttgccaac cttccttatt acgtaacaac accgattatc atgaaactgc 51061 ttgaagaaca tcttccgctg aaagggattg tggttatgct gcaaaaagaa gtggctgagc 51121 gcatggcggc tgatccttca tctaaggaat acggctcgct ttcaatcgcg gtgcagtttt 51181 atacagaagc caaaacggtg atgatcgtcc cgaaaaccgt atttgttcct cagcctaatg 51241 tcgattccgc agtcattcgt ctgattctcc gagacggccc ggcagtggac gtggaaaacg 51301 aatccttttt ctttcagctc atcaaggcaa gctttgcaca gcgccgtaaa acgctgctca 51361 ataacttagt taacaatctg cctgaaggaa aagcacaaaa atcaacgatt gaacaagtgc 51421 tcgaagaaac aaatattgac ggtaagcgcc gaggtgaatc cctgtctatt gaggaattcg 51481 cagcgctgtc taacggattg tataaagccc ttttctaaaa gggctttttg ttttgcgcac 51541 cacatggact gccgctacat aggctagaga aggacctttc attcaatgat aagaaaaaac 51601 ttggactcag cgaaaaaagg cgctttctca aggctctttc tttcatgatg aggcttagtc 51661 tatgtgtgga gtgaggaacg tgcaatttca aataggggat atggtagcca gaaaatccta 51721 tcagatggat gttttgtttc gaattatagg aatagagcaa acaagcaaag gaaattcaat 51781 tgccattttg catggagatg aagtcaggct gattgctgat tcggattttt ctgatctggt 51841 ggcagtgaaa aaggatgagc agatgatgcg gaaaaagaaa gatgagagca gaatgaatga 51901 gtcgctcgaa ttgctccgcc aagattataa gctgctcaga gaaaagcagg agtactatgc 51961 gacaagccaa tatcagcatc aggagcatta tttccatatg ccgggcaaag tgcttcatct 52021 ggatggtgac gaagcatatt tgaaaaaatg cctgaatgtc tataaaaaaa ttggagtgcc 52081 ggtctatggc atccattgcc atgaaaagaa aatgtctgct tctattgaag tattgctcga 52141 caaatatcga cctgacatcc tggtgatcac agggcatgat gcgtactcga agcaaaaggg 52201 cggtattgat gatttgaatg cgtacagaca ttctaagcac tttgttgaaa cagttcaaac 52261 agcccgaaaa aagatccctc acttagatca gcttgttatt tttgcggggg cctgccaatc 52321 ccattttgaa tcactcatca gagcgggtgc gaattttgca agttcaccgt caagagtcaa 52381 tattcatgcg cttgatccgg tatatatcgt cgcgaagatc agctttacgc cgtttatgga 52441 acggattaat gtatgggaag tgctccgtaa tacgctgaca agagagaaag ggcttggagg 52501 tattgaaaca agaggagttc tgagaattgg tatgccttat aagtccaatt aacagttgaa 52561 aacctgcata ggagagctat gcgggttttt tattttacat aatgatacat aatttaccga 52621 aacttgcgga acataattga ggaatcatag aattttgtca aaataatttt attgacaacg 52681 tcttattaac gttgatataa tttaaatttt atttgacaaa aatgggctcg tgttgtacaa 52741 taaatgtagt gaggtggatg caatggcgaa gacgttgtcc gatattaaaa gatcgcttga 52801 tgggaattta ggtaaaaggc tgacgttaaa agcaaacggt ggccgccgaa aaacgattga 52861 gcgttcgggc attttagctg agacgtaccc ttctgttttt gtgatacaac tagatcaaga 52921 cgagaactcg tttgaaagag tttcatacag ttatgctgat attttgactg agactgttga 52981 gctgacattt aatgatgacg ccgcaagctc agtggcattt taacgggcag tgaacctttt 53041 gtttactgct ttttgttttg cccttttttg gtttccaata attttaacga aagttccatc 53101 tgatttaaca aaagataaaa cagtcacata ttatcgtgac gtgcacgaat ggctatcact 53161 tctaaaaaag gagttgtttc gtttgggcag acgtcgtgga gttatgtcag atgagtttaa 53221 atatgagctg gctaaagacc ttggttttta tgacacagta aaaaatggag gctggggtga 53281 aattcgggcc cgcgatgccg gtaacatggt gaagcgtgct attgaaatcg ccgaacagca 53341 aatggctcag aatcagaata accgataagg atgtgacccg ggggacgtgc tgttccctgg 53401 tttttttatt ttggatataa atacataatg ggctgaatat ggatatgttc atcctgtact 53461 tcaaatgtga tacaatgttc atacttatgt ttagatggag aagtaggtga aagctatgcg 53521 tattttagaa aaagcgccag ctaagatcaa tctgtcactt gacgtcaccc gaaaacgccc 53581 ggatggctat catgaagtcg aaatgatcat gacgacaatt gatttagctg atcgaattga 53641 attgacggag cttgcagagg atgaagtgag ggtttcctcc cacaaccgat ttgtgcctga 53701 tgaccaaaga aacttagctt atcaggctgc caagctgatc aaggacagat acaacgtgaa 53761 aaagggagtt tccatcatga ttacgaaggt aattccggtg gctgccggtc ttgccggcgg 53821 aagcagtgat gcggcggcga cactcagagg gctgaacaga ctgtggaatt taaatctgtc 53881 cgcggaaacg cttgctgagc ttggagcgga aattggctct gacgtttcat tttgtgtcta 53941 tggcggaact gcattagcaa cagggcgcgg cgagaaaatt aaacatatca gcacgcctcc 54001 gcactgctgg gtcattttag cgaagccgac aatcggtgtt tcaactgctg aagtgtacag 54061 agcgctgaaa ctggatggta tagagcatcc cgatgtacaa ggcatgatcg aggcgataga 54121 agaaaagagt tttcagaaga tgtgcagccg gttaggcaat gtgcttgaat ctgttacact 54181 cgatatgcat cctgaagttg cgatgatcaa aaaccagatg aaacgctttg gtgcagatgc 54241 cgtgttaatg agcgggagcg gcccgacagt gtttggactg gttcagtatg agtcgaaggt 54301 gcagagaatt tataacgggt taagaggctt ctgcgatcaa gtttatgcgg tgagaatgat 54361 cggcgaacag aacgctcttg attaaatccg tatgttaagt tatattgatc ttaaaatatt 54421 cggattttgg gggtgagttc atgaagtttc gtcgcagcgg cagattggtg gacttaacaa 54481 attatttgtt aacccatccg cacgagttaa taccgctaac ctttttctct gagcggtatg 54541 aatctgcaaa atcatcgatc agtgaagatt taacaattat taaacaaacc tttgaacagc 54601 aggggattgg tactttgctt actgttcccg gagctgccgg aggcgttaaa tatattccga 54661 aaatgaagca ggctgaagct gaagagtttg tgcagacact tggacagtcg ctggcaaatc 54721 ctgagcgtat ccttccgggc ggttatgtat atttaacgga tatcttagga aagccatctg 54781 tactctccaa ggtagggaag ctgtttgctt ccgtgtttgc agagcgcgaa attgatgttg 54841 tcatgaccgt tgccacgaaa ggcatccctc ttgcgtacgc agctgcaagc tatttgaatg 54901 tgcctgttgt gatcgttcgt aaagacaata aggtaacaga gggctccaca gtcagcatta 54961 attacgtttc aggctcctca aaccgcattc aaacaatgtc acttgcgaaa agaagcatga 55021 aaacgggttc aaacgtactc attattgatg actttatgaa agcaggcggc accattaatg 55081 gtatgattaa cctgttggat gagtttaacg caaatgtggc gggaatcggc gtcttagttg 55141 aagccgaagg agtagatgaa cgtcttgttg acgaatatat gtcacttctt actctttcaa 55201 ccatcaacat gaaagagaag tccattgaaa ttcagaatgg caattttctg cgttttttta 55261 aagacaatct tttaaagaat ggagagacag aatcatgaca aaagcagtcc acacaaaaca 55321 tgccccagcg gcaatcgggc cttattcaca agggattatc gtcaacaata tgttttacag 55381 ctcaggccaa atccctttga ctccttcagg cgaaatggtg aatggcgata ttaaggagca 55441 gactcatcaa gtattcagca atttaaaggc ggttctggaa gaagcgggtg cttcttttga 55501 aacagttgta aaagcaactg tatttatcgc ggatatggaa cagtttgcgg aagtaaacga 55561 agtgtacgga caatattttg acactcacaa accggcgaga tcttgtgttg aagtcgcgag 55621 actcccgaag gatgcgttag tcgagatcga agttattgca ctggtgaaat aataagaaaa 55681 gtgattctgg gagagccggg atcacttttt tatttacctt atgcccgaaa tgaaagcttt 55741 atgacctaat tgtgtaacta tatcctattt tttcaaaaaa tattttaaaa acgagcagga 55801 tttcagaaaa aatcgtggaa ttgatacact aatgctttta tatagggaaa aggtggtgaa 55861 ctactgtgga agttactgac gtaagattac gccgcgtgaa taccgatggt cgcatgagag 55921 cgattgcatc catcacgctg gatcacgaat ttgttgtaca tgatattcgt gtgattgatg 55981 gaaacaatgg tcttttcgtt gcgatgccga gtaaacgcac ccctgatgga gagttccgcg 56041 atattactca tcctattaat tcaagcacgc gaggaaagat tcaagatgcc gtgttaaatg 56101 agtatcatcg tctgggtgac actgaagcat tagaattcga agaagctgga gcttcttaaa 56161 aaataaccaa aaagcaagga ctgctgaaag ggctgacata agccttttgc cggcggtcct 56221 tttttaattc tgatttttca aacttagttg cactcaatag aaaattcttg cacttcatga 56281 agtctccttg aaatcagaag atatttagga tatatttttc tatggataaa agggatattg 56341 gaggccaata aatggataag cggtttgcag ttgttttagc ggctggacaa ggaacgagaa 56401 tgaaatcgaa gctttataaa gtccttcatc cagtttgcgg taagcctatg gtagagcacg 56461 tcgtggacga agccttaaaa ttatctttat caaagcttgt cacgattgtc ggacatggtg 56521 cggaagaagt gaaaaagcag cttggtgata aaagcgagta cgcgcttcaa gcaaaacagc 56581 ttggcactgc tcatgctgta aaacaggcac agccatttct tgctgacgaa aaaggcgtca 56641 caattgtcat ttgcggagat acgccgcttt tgacagcaga gacgatggaa cagatgctga 56701 aagaacatac acaaagagaa gcgaaagcta cgattttaac tgcggttgca gaagatccaa 56761 ctggatacgg ccgcattatt cgcagcgaaa acggagcggt tcaaaaaata gttgagcata 56821 aggacgcctc tgaagaagaa cgtcttgtaa ctgagatcaa caccggtacg tattgttttg 56881 acaatgaagc gctatttcgg gctattgatc aggtgtctaa tgataatgca caaggcgagt 56941 attatttgcc ggatgtcata gagattctta aaaatgaagg cgaaactgtt gccgcttacc 57001 agactggtaa tttccaagaa acgctcggag ttaatgatag agttgctctt tctcaggcag 57061 aacaatttat gaaagagcgc attaataaac ggcatatgca aaatggcgtg acgttgattg 57121 acccgatgaa tacgtatatt tctcctgacg ctgttatcgg aagcgatact gtgatttacc 57181 ctggaactgt gattaaaggt gaggtgcaaa tcggagaaga tacgattatt ggccctcata 57241 cggagattat gaatagtgcc attggcagcc gtacggttat taaacaatcg gtagtcaatc 57301 acagtaaagt ggggaatgat gtaaacatag gaccttttgc tcacatcaga cctgattctg 57361 tcatcgggaa tgaagtgaag atcgggaatt ttgtagaaat taaaaagact caattcggag 57421 accgaagcaa ggcatctcat ctaagctatg tcggcgatgc tgaggtaggc actgatgtaa 57481 acctgggctg cggttcaatt actgtcaatt atgatggaaa gaataagtat ttgacaaaaa 57541 ttgaagatgg cgcgtttatc ggctgcaatt ccaacttggt tgcccctgtc acagtcggag 57601 aaggcgctta tgtggcggca ggttcaactg ttacggaaga tgtacctgga aaagcacttg 57661 ctattgccag agcgagacaa gtaaataaag acgattatgt gaaaaatatt cataaaaaat 57721 aatcctaaat tcggaggttt atccatgtct aatcaatacg gagataagaa tttaaagatt 57781 ttttctttga attcgaatcc agagcttgca aaagaaatcg cagatatagt tggagttcaa 57841 ttagggaaat gttctgtcac aagatttagt gacggggaag tccaaattaa tatcgaagaa 57901 agtattcgcg gatgtgattg ttacatcatc cagtctacaa gtgaccccgt taacgagcat 57961 attatggaac tgctgattat ggtagatgcg ttaaaacgcg cttctgcaaa aacgattaac 58021 attgttattc cttattacgg ttatgcgcgt caagacagaa aagcaagatc ccgtgagcca 58081 atcacagcta aacttttcgc taacctgctt gaaacagccg gtgcgactcg tgtgattgca 58141 cttgacctgc atgcgccgca aattcaagga ttctttgata taccgattga ccacttaatg 58201 ggtgttccga ttttaggaga atattttgaa ggcaaaaatc ttgaagatat cgtcattgtt 58261 tcaccagacc atggcggtgt gacacgtgcc cgcaaactgg ctgaccgact aaaagcgcca 58321 attgcgatta tcgataaacg ccgtccgcgt ccaaacgtgg cggaagtcat gaatattgta 58381 ggtaacatcg aagggaagac tgctatcctc atcgatgaca ttattgatac tgcaggtacg 58441 attacacttg ctgctaatgc gctcgttgaa aacggagcga aagaagtata tgcatgctgt 58501 acacaccctg tactatcagg ccctgcggtt gaacggatta ataattcaac aattaaagag 58561 cttgttgtga caaacagcat caagcttcct gaagaaaaga aaattgaacg ctttaagcag 58621 ctttcagtcg gaccgcttct ggccgaagcg attattcgcg ttcatgagca gcaatcagtc 58681 agctatctgt tcagctaaac catttttcga ggtttaaatc cttatcgtta tgggtattgt 58741 ttgtaatagg acaactaaaa cgacaagagg atggtgctga atatggcaac tttaacggca 58801 aaagaaagaa cggactttac tcgttcgtct cttcggaata tccgtacttc aggacatgtt 58861 ccaggtatca tatatgggaa ggatacgggt aacaaacctg tgtcattaga cagtgtggag 58921 ctcatcaaaa cgctgaggga cgaaggcaaa aatgcagtca ttacgcttga ggtcagcgga 58981 gaaaaacact cagtcatggt aacagacctg cagacggacc cgctgaaaaa tgaaatcact 59041 catgctgatt ttcaagtagt taatatgagt gaggacattg aagtggaagt tccgattcat 59101 ctgaccggag aagccattgg agtgaaaaac ggaggcgtac tgcagcagcc gttatatgca 59161 cttactgtaa aggccaagcc aaaagccatt ccgcaaacga ttgaggctga tatttcaagc 59221 ctcgatgtaa atgaagtact gacgattgcg gatttgcctg ctggcggtga ctactccttt 59281 aatcatgaat cagatgaggt tgtggcttca atccttcctc cgcagcagca ggaagcagct 59341 gaggtcgatg aagaggaatc tgccgatgct cagcctgaag gtgaaaacga acaataatag 59401 cttaaggcgt aaccctcccg cggttacgtc ttttgtgcta gaatgagaag aattatagcc 59461 cgtttatgaa gacgggagtt atgtgactaa gggaggattc gccatgcttg tgattgccgg 59521 tctcggaaac ccggggaaga actatgaaaa tacacggcat aatgtcggat ttatggtgat 59581 agatcagctt gcaaaggaat ggaatataga gctgaatcaa aataaattta acggattata 59641 cggaaccgga tttgtttccg gcaaaaaggt tctacttgtt aaaccgctta catatatgaa 59701 tttatcagga gaatgtttgc ggcctttaat ggactactat gatgtcgata acgaagattt 59761 gacagtcatt tacgacgacc ttgaccttcc gactggcaag atccgtttaa gaacgaaagg 59821 aagcgccgga gggcacaatg gcatcaaatc actgatccag catcttggaa cgtccgagtt 59881 tgaccgtatc cgcatcggaa tcggccggcc tgtaaacggc atgaaggtcg ttgattatgt 59941 gttaggctcc tttaccaagg aggaggcacc tgagatcgaa gaagcggttg ataaatctgt 60001 gaaggcttgt gaggcttctt tgagtaaacc gtttttagaa gtcatgaacg aatttaacgc 60061 aaaggtataa aatgtaacaa caaagtccat actacaccaa aatgactttt tcatcaggag 60121 gacccttgta tggctttgca ttattattgt cgtcattgcg gagtgaaagt aggcagtctc 60181 gaatcttcaa tggtatcgac agactcactt ggatttcagc acttaacaaa tgaggaaaga 60241 aacgatatga tttcttataa agaaaatgga gatgtccatg ttttgacgat atgtgaagac 60301 tgccaagagg cgcttgaccg aaatccgcat taccacgaat atcacacatt tattcaataa 60361 aaagctttgg tgtagacact agaccaaagc gtttttctgt tctcgcagga aacagagagg 60421 aggggccata tggacaacat tcaaaccttt ataaaagaaa gcgatgactt taaatccatc 60481 atcaacggtt tacacgaggg cctgaaggaa cagctgctcg cgggtctgtc gggttccgcg 60541 cgttctgttt ttacttctgc tctggctaat gaaacgaata agcctatctt tctcatcacc 60601 cataacttat atcaagccca gaaagtaaca gatgatctga cttcacttct agaggatcgg 60661 tctgtccttt tgtaccccgt caatgaactc atttcatcag aaatcgcagt tgcaagccct 60721 gaattgcggg cgcagcgatt agatgtcatt aatagactaa cgaatggaga agcgccaatt 60781 gtcgttgctc cggtagctgc aatcagaaga atgctgccgc ctgttgaggt gtggaaaagc 60841 agccagatgc tcattcaagt aggccatgat attgaacctg accagcttgc ctcacggctg 60901 gtagaggtag ggtatgagcg gtctgatatg gtttctgcgc ccggggaatt cagtattcgc 60961 gggggaatca ttgacattta tccgctgact tcagagaatc cggtgagaat tgaacttttt 61021 gacaccgagg tggattcaat ccgcagcttt aattcagatg atcagcggtc aattgagacc 61081 cttacctcga tcaatatcgg tcccgcgaag gaattaatta tcagaccgga agaaaaagcg 61141 cgggcgatgg agaaaatcga tagtggtctt gccgcgagct tgaaaaaatt aaaggctgac 61201 aaacaaaaag aaatacttca tgcgaatatt tctcacgata aagaacgctt gtctgaaggc 61261 cagacagatc aggagctcgt gaagtatctc tcatatttct atgaaaagcc tgctagttta 61321 ctagattata cacctgataa tacacttctg attttggatg aagtcagtcg gattcatgag 61381 atggaagaac agcttcaaaa agaagaagcg gagtttataa caaatcttct tgaggaaggg 61441 aagattttgc atgacattcg tttgtcattc agcttccaaa aaatagtggc tgagcaaaaa 61501 cggcctctgc tgtactactc tttatttttg cggcatgtac accatacgag cccgcaaaat 61561 atcgtcaatg tgtcaggccg gcaaatgcag agtttccatg gccaaatgaa cgtgcttgcg 61621 ggcgaaatgg agcgttttaa aaaatcaaat ttcactgttg tgttcttagg agcaaacaag 61681 gaacgtacgc agaaattgtc atctgttttg gctgattatg atatcgaggc cgccatgaca 61741 gacagcaaaa aagcgcttgt tcagggacag gtctatatca tggaaggcga gctccaatcg 61801 ggatttgagc tgccgttaat gaagcttgcc gttatcacgg aagaagaact gttcaaaaac 61861 cgtgtaaaga agaagccgcg aaaacagaag cttaccaatg cagagcgcat caaaagctat 61921 tctgagcttc aaattggaga ttatgtcgtt catattaatc acgggatcgg aaaatacctg 61981 gggattgaaa ctcttgaaat caacggcatt cataaagact atttaaatat acattatcag 62041 ggcagtgaca agctttacgt ccctgtagaa caaattgatc aggtccaaaa atatgttggc 62101 tccgaaggaa aagagccaaa gctgtataaa ttaggcggaa gtgaatggaa gcgggtcaag 62161 aaaaaagtag agacatccgt tcaggatatt gctgatgact taattaagct gtatgccgaa 62221 agagaagcga gcaagggcta tgcgttttct cctgaccatg agatgcagcg tgaattcgaa 62281 tcggctttcc cttatcaaga gactgaggat cagctccgtt ctattcacga aatcaaaaaa 62341 gacatggaaa gagaacgtcc gatggaccgc ttgctgtgcg gagatgtggg ctacggtaaa 62401 acagaggttg ccatacgtgc cgcgtttaag gcgatcggtg acggaaagca ggtagctctg 62461 ctcgttccga caaccatttt ggcacagcag cactatgaaa ccataaaaga gcgcttccag 62521 gactatccga ttaatatcgg ccttctcagc aggttcagaa cgagaaaaga agcaaacgaa 62581 acaatcaaag ggctgaaaaa tggaacggtt gatatcgtca tcgggacgca tcggctgcta 62641 tcaaaggatg tcgtgtataa agacttaggg ctcctcatca ttgatgaaga gcagcgtttc 62701 ggtgtaaccc ataaagaaaa gatcaagcaa ataaaagcca atgttgatgt attaacgtta 62761 acagcaacgc cgattccgcg tacgctgcat atgtctatgc ttggcgtaag ggacctttca 62821 gtcatcgaga ctccgccgga aaatcgcttc cccgtacaga cgtatgttgt ggaatataac 62881 ggcgctcttg tcagagaggc gattgaacgt gagcttgcac gcggaggcca ggtctatttc 62941 ttgtacaacc gggtagagga cattgagcgg aaagcggatg aaatttcaat gctagtccct 63001 gacgcgaagg tagcatatgc gcatgggaaa atgacagaaa atgaattaga aaccgttatg 63061 ctaagcttcc ttgaaggaga atcagacgtt ctcgtcagca caaccattat cgaaactggc 63121 gtggacatcc caaacgtcaa tacgctgatc gtatttgacg ccgacaagat gggactttct 63181 cagctttacc agctgcgggg gcgtgtcggc cgttctaacc gtgtggcgta tgcgtacttc 63241 acgtatcgcc gggataaagt gctgacagaa gtggctgaaa aaaggctgca ggctattaaa 63301 gaattcacag agttaggttc cggttttaaa atcgcaatgc gtgacttaac gattcgcgga 63361 gccgggaatc ttcttggtgc ccagcagcat ggcttcatcg attcggtcgg atttgacctc 63421 tattcacaaa tgctgaagga ggccattgag gagcgtaaag gagacacagc gaagacagag 63481 cagtttgaaa cagaaattga tgtcgagctt gatgcgtata ttccggaaac ttatattcaa 63541 gacggcaaac agaaaattga tatgtataaa cgcttcaggt ctgtggcgac aatcgaagag 63601 aagaatgagc ttcaagatga aatgatcgac cgctttggaa actatccaaa agaagtcgaa 63661 tacttgttta ctgttgcaga aatgaaagtc tatgcgagac aggaacgtgt cgagctgatt 63721 aagcaggata aagatgctgt cagattgacg atttctgaag aagcaagtgc tgaaattgac 63781 gggcagaagc tgtttgagct tggcaatcaa tatggcagac aaatcggact gggaatggaa 63841 gggaaaaaac tcaaaatctc catacagacg aaaggccgta gtgctgatga atggctcgac 63901 accgtgctgg gcatgctgaa gggcttaaaa gatgtgaaaa agcaaaccat ttcatcaacg 63961 taaattttgt tactctctgg tgtatattac atttgatgtg acggatacta atttcaagcg 64021 aggcggaagg tacataaagt aactgcttta ggtctttccc acatgtatat accatcaaat 64081 gaaagagagg caccagagat gaaagcaacc ggtatcgtac gtcgtattga tgacttaggt 64141 cgggtcgtga ttcctaaaga aattcgaaga actctgagaa tcagggaagg cgatccgctt 64201 gagatttttg tagatcgtga cggagaagtg attttgaaaa agtactctcc gatcagtgag 64261 cttggagact ttgcaaagga gtatgcagac gcgctttacg acagcctcgg ccattcagtg 64321 ctgatttgtg atcgtgatgt atatattgcc gtgtccggca gctccaaaaa agattactta 64381 aacaagtcaa tcagcgaaat gctggaaaga acaatggatc agcgcagctc cgtgcttgag 64441 agtgatgcga aatcagtaca gcttgtgaat ggaattgatg aggacatgaa ttcttatact 64501 gtaggcccaa ttgtggcgaa cggtgatccg ataggtgctg tggtgatctt ttcaaaagat 64561 cagacaatgg gcgaagtaga gcataaagcc gttgaaacag cagctggatt tttggctcgt 64621 caaatggaac agtaggtctt attcctttct tcgaaaatag gtatgtaaag aacagctctc 64681 cttgggacgc tgttcttttt catgcgtgcc gaaaaaggaa tccaagggtt gggatgtggt 64741 ataataacct cgtttttatt tgtgccgcgg taatacgtga accgtattgc ccctgacgtt 64801 gggaaggagc ttttggatgg acgattcaat aggcgttaaa cggcattgga tttggcaggg 64861 ggcttttgtt ttaattctgg caggcgtcat cacaaaaatt ttaagcgctg tttacagagt 64921 cccgtttcaa aacattgtcg gcgatgttgg attttatata tatcagcagg tatacccctt 64981 tcttggtatt gcggtcatgc tgtccacatc aggatttcca gtcattattt caaagctgat 65041 gaatgattat agtgaaaaaa atcatcacac catattaaaa atatcagcgt tgtttttgtc 65101 tttaatcggt attttattat ttctttgttt atatctgggt gctgttccta ttgcactctt 65161 tatgggagat tcgcatctag ccgtgttaat tcaagtggcc gcatacgcgt ttctgctttt 65221 cccatttgtc gcgttgctaa gaggcggttt tcaggggcgg cacgaaatgc tcccttcagc 65281 cttatcacag atgacagagc agtttctgcg tgttgcggtg ctcttgggtt tatcattttg 65341 gctcgtgaaa aagggagcct cgctttatac tgcgggagcg gcagccgctt caggctctct 65401 tgccggaagt ttggttgcat tgataatact ggggtttttt tggttcaaaa cgaaaagaga 65461 caaccaaacg gataggcaaa acgaaaatgt catcacaaca aaagaattga cgaaaaaact 65521 gcttttatat tcggtcacaa tttgtgtaag cagtttgctg cttttgttta tccagcttgt 65581 tgatgctttg aatttatatg cattgctttc gggtggtgag gcaagcgaag aagcaaaatg 65641 cctaaagggg atctatgatc ggggacaacc cttgttgcag ctcggttcag tttttgccgt 65701 aagcattgcg acgtcactcg ttccgtatat ttctatggct gtaaaaaaca aagagctgaa 65761 gatcatgaaa gaaaaaatca cgtcatcttt gaaactatgc cttgtgctcg gtacaggcgc 65821 atcggctggg ttgatttgca ttctaaagcc ggtaaatatc atgctgtttc aaaatggaga 65881 agggacaggt gcgttacaag tatttagctg ctccattttg tttgcatcct tggcggtaac 65941 ggcagcggca gtcttacagg gagcgggata cacagttttt cctgcgatag cggtgggcgc 66001 gggtgttgcg gtgaaatggg tgttaaacac acttttggtt ccgcgctatg ggattgaagg 66061 cgcatcgctt gcgacagcgg cttcctttgc ggctgtcgcc ggccttaact tgtatcagct 66121 tcggcaaaag gaatggctcg ataagcttag aggcgttttg attccgatta ttggatctgc 66181 tcttttgatg tcagctgttt tgcttgcgta tacgcgtctc tggactttct tgtttcctgc 66241 aacaggaaga ggagcggctg tgattgagag tctttctgct gttgccattg gtggcgcggt 66301 gtttatttat tgtatgatga gattgggaat atttacagat gaagagctga acagtgtgcc 66361 attcggcagc aagttaagca aattcatgag aaggagagaa caaaatggcg ggtaaaatta 66421 cagtcgtcgg acttggtgcc ggagacatgg accaattgac aattggtata cacaagctgc 66481 tgacgaaggc agatacgctg tatgtcagaa ccaaggatca tcctttaatt gaggagcttg 66541 aaaaagaaac gaagaacatc cgtttctttg atgatatata tgagaaacat gatcagttcg 66601 aggcggtata tgaagaaatt gcagatatcc tctttgaagc ggcgcggcgt gaggacgtgg 66661 tttacgctgt gccgggacac ccttttgtcg cagaaaaaac agttcagctg ctgacggagc 66721 ggcaggaaaa ggaaaacgtt caagtgaaag tcgcgggggg acaaagtttc cttgatgcca 66781 cattcaatgt cttgcaaatt gacccgattg aaggttttca atttgtggat gccggcacat 66841 tgtccgcgga tgagcttgag ctcagacatc atctgatcat atgtcaggtt tacgaccaaa 66901 tgacggcttc tgaagtcaag ctgacattga tggagaagct gcctgatgat tatgaggtcg 66961 tcattgtgac tgcagcaggc agccgtggcg aggagatcag gacagtgcca ttatttgagc 67021 tggaccgcaa tgtcgctttg aacaacttaa caagtgtgta tattccgccg attaaagaag 67081 agaagctgct ttatcacgaa ttctccacgt tccgaagcat catcagagag cttcgcggac 67141 ctaatggatg tccgtgggat aaaaagcaga cgcatcagtc attaaagcag tacatgattg 67201 aagaatgtta tgagcttctc gaagctattg acgaagaaga cacagaccat atgatcgaag 67261 agcttggcga cgttttgctt caggtcttgc ttcacgcgca aattggtgaa gatgaaggtt 67321 atttcacaat tgatgatgtc ataaaaggaa tcagtgaaaa aatggtccga agacatcccc 67381 atgtgtttaa agatgttaag gttcaggatg aaaacgatgt tttagccaat tgggaagata 67441 taaaaaaggc cgaaaaaaat acatctgaat catcattact agacagcgta ccgaaaaccc 67501 ttccagctct ttcgaaagca gctaaattgc agaaaaaagc agcgaaggtc ggttttgact 67561 gggaagacgt cagcgatatt tgggaaaagg taagtgagga aatgaaggaa ttttcttctg 67621 aggtttctga agctcctcac gaacacaatc ttaaagctga gtttggcgac attttgttcg 67681 cgctggtgaa tgtagcccgc ttctacaaaa tagagccaga ggaagcgctg accatgacta 67741 atgacaaatt ccggagacgg ttctcgtaca ttgaggaaac agcgaaggaa gagggagtcg 67801 agttggctga tatgtccctt gaggacatgg acaaactgtg gaatgaagca aaagaaactg 67861 agaggagatc atagatatga gattagataa atttttgaaa gtatcacggc tgatcaaacg 67921 gcgtacacta gcgaaggaag tagctgacca aggacgaatc tctattaacg gaaaccaagc 67981 taaagctagc tctgacgtaa aaccgggaga tgaactaacg gtccgcttcg gccaaaagct 68041 tgtaacggtt caagttaatg aattgaaaga cacgacgaaa aaagaagaag ctgcaaacat 68101 gtacacgatt ctaaaagaag aaaaactcgg cgaataggct tgttctaaaa aaacccccca 68161 cctcatacaa tgcagtaata atgctaaaag tatcgaggat atgggggctg aatagatgaa 68221 ttcatattat gatcaaaaag gttcttcgtc tgttccggaa cagcatgatg tgacaatgaa 68281 aggccggaag catttagata tttctggggt taagcatgtg gagagttttg ataacgaaga 68341 attcctgctg gaaacggtga tgggaatgct ctccgtcaga ggccaaaacc tgcagatgaa 68401 aaatcttgat gtggaaaaag ggattgtttc gattaaaggc agggtatttg atttagtgta 68461 cttagacgaa caacaagggg ataaagctaa agggtttttt agcaagttgt ttaaatgacg 68521 ctgacgacac aattctatac aatgctagcg atgtccggta tgggtctctg gcttggtgct 68581 tcgcttgata cataccggct ctttgtcatt cgtgccaaaa cagccagatg gctattattt 68641 attcatgata ttcttttctg gattatgcaa gggctgcttt tcttttatgt cttgcttcat 68701 gtaaatgagg gagaattcag gatttacatc tttttagcgg ttctgctggg cgttgcgacg 68761 tatcagagcc tttgcaaacg aatctatata aaaatactga aattcgtcat ttaccttgtt 68821 gtttctgttt atcaattctt caaaaaactc attcagcacg tgttatttcg tcctattgtg 68881 tggacatgcg gagcgatcat ctggctggcg gcatttttat tcaagaaaac atacagcctg 68941 ataggttttc tcctgctgtg tctatataaa atagtcatgg ttctgtgttt tccgatccgt 69001 tttatcgcga aacaatgttt gaaacttctt cctgtgaaaa tgcgtctaac ttttagacgt 69061 tattttgaaa aaggtgcagg atttctcaaa aagaagaaga aactattgat aaccataaga 69121 acgaccatca cacggttttt gaagagatga aaggaggacc gtctggtttg aatttttcca 69181 gggaacgaac gataactgaa atacaaaacg actataaaga acaagtagaa cggcaaaatc 69241 agctgaagaa acgaagacgc aaagggctgt acagacggtt aactgtattc ggcgccctag 69301 tattcctgac ggcaattgtg ctggcaagct ctgtatggtc ccaaacatct tcccttagtg 69361 caaaagaaga aaagaaagaa cagcttgaaa aagaactgaa aagtttaaag acaaaacaaa 69421 cggatttaaa agaagaaata tccaaattga aggatgagga ttacgtcaca gagcttgcca 69481 gaagggactt attcatgtct ggagacggag aaattatctt caatgtggag aagaagagca 69541 agtagccttg ttgacactta aatttttatt taggtataat taagcaaacg atctttttat 69601 aagcctaagg aggagcactt tttttatgtc gattgaagtt ggcagcaagt tgcaagggaa 69661 aattacaggt attacaaatt ttggagcatt tgttgaattg cctggaggct caaccggtct 69721 cgttcacatt agtgaggtag ctgataatta tgtcaaagac attaacgacc acttaaaagt 69781 cggcgaccaa gttgaagtga aagtcatcaa cgttgaaaaa gacgggaaaa ttggtttatc 69841 tattaaaaaa gctaaagacc gtccgcaagc cagacctaga aatgatttcc gtccgaaaga 69901 atcttttgaa cagaaaatga ataagttttt aaaagacagc gaagatcgct tgtcatcttt 69961 aaaacgcaat acggaatcaa aacgtggagg gcgcggagca agaagaggat aacttgctgc 70021 tttctataaa ataaatgaag catccgttca tcccgacgga tgctttttta ttatcctcat 70081 tctctttaag agtcagaaaa ttacaacatt aaagtttctg ttgacgaaag agacaaacct 70141 ttgtattata taacttgtgc ttagaagcac aaaacaatat ggcggtgtag ctcagctggc 70201 tagagcgtac ggttcatacc cgtgaggtcg ggggttcgat cccctccgcc gctaccatat 70261 ttgtttggcc cgttggtcaa gcggttaaga caccgccctt tcacggcggt aacacgggtt 70321 cgaatcccgt acgggtcatc ctaacaaatc ggtttctctt gcagaagccg atttttttca 70381 tttttagaca acattccgga aattcttttc ataaacgaat atcaaggcag aaaccgtcga 70441 agatttcttt ggtattgtta ccttcttttg acaaaatcct atctgtgctt tcgctataat 70501 gacaggcaac gaatataaca ggtgggagat gagaggaatg gaaaaagcag aaagaagagt 70561 gaacgggcca atggcgggac aagctttgga aaaactccaa tcgtttttta acaggggcac 70621 gaagctggtg actcatcatt tgcattcact gtttttctat aaaggattca tttatgttgt 70681 catcggattt ttgcttggac gggctttcat attatccgag gtgcttcctt tcgcacttcc 70741 tttctttgga gcgatgcttc ttatcagaag agacaaagcg ttttatgcgg ttttggctgt 70801 gcttgcaggt gcgctgacca tatctccaaa gcactcattg ctcatactgg cggcattgct 70861 ggcattcttc gtattttcta aagtggctgc cttcattacc gacgatcgtg ttaaagcgct 70921 cccgattgtc gtgttcttct ccatggctgc agcaagagcc gggtttgttt atgcccaaaa 70981 tggcgtattt acaacctatg attatgtaat ggctatcgtt gaggctggac tatcgtttat 71041 cttaacactg attttccttc agagccttcc gatttttact gtgaaaaaag tgaaacaatc 71101 attaaaaata gaggaaatca tttgctttat gattcttatt gcctctgttt taacggggct 71161 ggctggcttg tcctaccaag ggatgcaggc agaacatata ttggctcgtt atgttgtgtt 71221 gagtttttcc tttattggcg gagcaagcat cggctgtacg gttggggttg tgaccggcct 71281 gattcttggc ttggcgaata tcggaaacct atatcaaatg agtctgcttg ctttttccgg 71341 tttattgggc ggtttgctga aggaagggaa aaaagcgggt gcagcaattg gtttgatcgt 71401 tggatcactt cttatatctt tatatggtga aggctctgcc ggtctgatga caacgctcta 71461 tgagtcatta atcgcagtct gcctgttttt gctcacacct caatctatta cgaggaaagt 71521 ggcgagatat attccgggaa ctgtcgagca tcttcaagag caacagcaat acgctagaaa 71581 aatccgtgat gtcactgctc agaaggtaga ccaattctcc aatgtatttc acgcgctgtc 71641 tgaaagcttt gcaacctttt atcaagcatc agacgaacag acagatgaca gcgaagttga 71701 tctgttctta agcaaaatca cggagcattc ctgccagacg tgctacaaga aaaacaggtg 71761 ctgggtacag aactttgata aaacatatga cttaatgaaa caagttatgc ttgaaacaga 71821 ggaaaaagaa tatgcatcaa accgaaggct gaaaaaagag tttcaacagt attgttctaa 71881 atccaagcag gttgaagagc tgattgagga tgagctcgca catcatcatg cccatttgac 71941 actcaagaaa aaagtccaag acagcaggcg ccttgttgct gaacagcttt taggcgtttc 72001 tgaggttatg gccgactttt ctcgggaaat aaaaagagag cgagaacaac actttctgca 72061 ggaagagcaa atcatagaag cgcttcagca tttcggaatt gagattcagc atgtcgagat 72121 ctatagtctt gaacaaggaa atatcgatat tgaaatgacc attccgttca gcggacatgg 72181 agaaagtgaa aaaatcattg ctcctatgct ttctgacatt ctggaggaac aaattcttgt 72241 gaaagccgaa cagcactctc cgcatccgaa tggatacagc catgtcgcct ttggatcaac 72301 aaaatcatac agggtgtcca cgggagctgc tcacgctgcg aagggcggcg gccttgtctc 72361 cggtgacagc tacagcatga tggagcttgg agccagaaaa tatgctgcag caatcagtga 72421 cggaatgggc aatggcgcaa gagcgcactt tgaaagcaat gaaacgatca agcttcttga 72481 aaaaatcctt gaatcgggca ttgatgaaaa aatagcaatt aaaacgatca acagcatact 72541 gtctctaagg acaactgacg aaatatattc cacgcttgac ctatctatta tcgatcttca 72601 agatgccagc tgtaaatttt tgaaggttgg atcgacgccc agctttatca aacggggtga 72661 ccaggtcatg aaagttcaag cgagcaatct gccaatcggt attattaatg aattcgatgt 72721 ggaggttgtg agtgaacagc tgaaagcggg tgacctctta attatgatga gtgatggcat 72781 ttttgagggg cctaagcatg tggaaaatca cgacttatgg atgaagcgta aaatgaaagg 72841 gttgaaaaca aatgacccgc aggagattgc cgatttgctt atggaagaag tcatccgcac 72901 aagatccggc caaattgagg acgatatgac tgttgttgtc gtccggattg atcacaatac 72961 accgaagtgg gcatccattc ctgttccggc aatctttcaa aacaaacaag aaatttcata 73021 acgcttccgt ataaatcaaa tttcttctgg cgaagatggg aatatatgaa tctgagaatc 73081 ctcgtattct ccaggaggaa tgaatgtgaa caacggacat ttaaatcaaa ttttgctgat 73141 aacggatggc tgctcaaacc atggggaaga cccgcttgca atggctgctt ttgctaaaga 73201 gcaggggatt acggtaaatg tcattggtat aatggaagaa aatcaaattg accctgaggc 73261 aatgaaggaa gtcgaaggga ttgcacttgc cggaggaggc gtgcaccaag tcgtttatgc 73321 atctcagctt tcacaaactg ttcaaatggt aacaaagaaa gcgatgacgc aaaccttaca 73381 aggtgtagtc aatcaagaac tgaaacagat tctcggaaag aatgtggaaa tggaagagct 73441 ttctccggaa aaacgcggcg aagtcatgga agtggtagac gagcttggag aaacggtgca 73501 tcttcaggtt ttggttcttg ttgatacaag tgcaagtatg gcgccaaagc ttccaacagt 73561 aaaagaggcg ctgattgatt tgtctgtaag cctcaattcc cgaattggga ataacgaatt 73621 tgcgatgtgt atatttcccg ggaaaaaaca agaggtcgag cttgtgctga actggacacc 73681 gaagctgcaa tctctttcca cactctttgc aaagctttcg acaggcggca tcacgccgac 73741 aggtccggcg attcgtgaag cgacactgca gtttgaaaaa atacgctcaa gaaggggcat 73801 gctggcagat gatgaacgac gctttgacga gtttggcatg tagcctcaag ccgggtacga 73861 caatcaaagg caagtggaat ggaaacactt atacattgcg taaacagctt ggtaaagggg 73921 ccaatggaat tgtgtatttg gcagaaacat cagatggaca tgttgcctta aaggtgagtg 73981 atgacagcct gtctattact tctgaagtga atgtcttgaa atctttctca aaggcccagt 74041 ccgttacgat ggggccttct ttttttgata cggatgatgc ctatattccc agtgccaata 74101 cgaaagtttc attttatgca atggaataca taaaagggcc gctgcttttg aagtatgtca 74161 gtgataaagg agcagagtgg ataccggtat taatgattca gctgttatcc agcttatcgg 74221 tgcttcacca gcaaggatgg atattcggcg atcttaaacc tgataatctg atcgtaactg 74281 gtccgcccgc aaggatccgc tgcattgatg tgggcggcac gacaaaggaa ggccgggcga 74341 taaaagagta tacggagttt tatgacagag gctattgggg gtatggaaca agaaaggcag 74401 agccatccta tgatctgttc gcagttgcca tgattatgat caacagtgtg cataaaaaag 74461 aatttaagaa aacgaaccag cccaaagaac agcttaggtc tctcatcgaa ggaaacccgc 74521 tgcttcaaaa gtataaaaaa gcgctttttt cagccttgaa cggagattat caatccgcag 74581 atgaaatgaa aaaggatatg ctagacgcgg ggcaaaaagc agcacaaaga aaacagccta 74641 taaaagcatc accgcagcct gccacacgac aaagacagca aaaaccgcgc caaggaaaaa 74701 taacgaagac gcgatatacc ccaaaacaga aaccggctaa gtcggggggg ttatttgaaa 74761 caacgcttat cgtgatcagt gttttagcgc tttatttcgc ctatattatc tttttcttaa 74821 tctgaatggt gcaaactgca gagcctatgc ttcttctttg cttggagggg ttgaaagtgt 74881 taggatatga atatctttaa aatacctgct cattgtgagg aggacattgt gaaaagtgtc 74941 aaagattttt taaacaaaca caatcttacg ttaaaagggg cgacaatcat tgtaggcgtt 75001 tccggcggtc cggactcaat ggctcttctt cacgcgttgc atacgttatg cggccgttca 75061 gcgaatgtta ttgcagctca cgttgaccat cggttcagag gtgcggaatc cgaggaggac 75121 atgcgttttg tccaagctta ttgtaaagct gaacagctcg tgtgcgaaac ggctcaaatc 75181 aatgtaaccg catatgcaca ggaaaaagga ctcaataagc aggctgcagc acgcgattgc 75241 cgctaccagt tttttgagga aatcatgtcg aagcaccaag cggactatct ggctcttgcg 75301 catcatggtg atgaccaggt tgaaacaatg cttatgaaac tggctaaggg tacgcttgga 75361 acgggacttg cgggaatgca gccggttaga cgttttggga cagggcggat catcaggccg 75421 ttcttaacca ttacaaagga agagatcctt cactattgcc atgaaaacgg cttgagctac 75481 cggacggatg aaagcaacgc caaagatgac tacacaagaa acagattcag aaaaacagtg 75541 ctcccgtttt tgaagcagga atctccggat gtgcataaaa ggtttcagaa agtgagtgaa 75601 gcactgacgg aagatgagca attcttacag tcattaacga aagatgaaat gaataaagta 75661 atcacaagcc agtctaatac atcagttgaa atcaattcct ctcaattgct tgccctcccg 75721 atgcctttac aaagaagagg agttcaacta atattaaact atctttatga aaacgttcca 75781 tcatcctttt cagcccatca cattcagcag tttctcgatt gggcggaaaa tggcggtcct 75841 tcaggagtac tggactttcc gaaagggctg aaggtggtca aatcatatca gacatgtttg 75901 tttacatttg aacaatggca gtgcaaaaat gttccctttg aataccaaat tagcggagct 75961 gctgatgaaa cggcagtgct ccctaatgga tatctgatag aggcaaggca ttatgcggac 76021 tcgcctgaag aacatgggaa tgctgttttt atcacaagtg aaaaaaaggt gcgatttccc 76081 ttaacaatcc ggacgagaaa agctggagac cggatcaaac taaaagggat gaacggctca 76141 aaaaaggtaa aggatatatt tattgataag aaattgcctc tccaagaaag agacaactgg 76201 ccgattgtga cggacgcaag cggtgaaatt atctggatac ctggcttgaa aaaatcaatt 76261 tttgaagatc ttgtgattcc aaacagcgac cgcattgtat tacaatatag acagcatgaa 76321 aagtgtaggg ggcaagcaaa atcatgatga aacatgatat cgagaaagta ctgatctcag 76381 aggaagagat acaaaagaaa gtaaaagagt taggtgcaga attaacgagc gagtatcaag 76441 atacatttcc gttggcaatc ggtgtgttaa aaggagcact tccttttatg gcggatctta 76501 tcaagcatat tgatacatat ttggaaatgg atttcatgga tgtatcaagc tacggaaatt 76561 ctacggtttc ttctggagaa gtaaaaatca ttaaagattt ggatacatct gtagagggcc 76621 gggacatctt aattattgaa gatatcatcg acagtgggtt aaccttaagt tatctcgtag 76681 agctcttccg ataccgtaaa gcaaaatcaa ttaagattgt tacccttttg gataaaccga 76741 gcggaagaaa agcggacatc aaagcagact ttgtcggttt tgaagttcct gacgcgtttg 76801 tagtgggtta cggacttgat tatgctgagc gctatcgcaa tctgccttat atcggagtgt 76861 taaaaccggc agtttatgaa agctgatcgg cagcctgctt ccgagatggt tattgtttgt 76921 attggaatga ttttctatgg tactattgaa catagttgtg cttactgtgg gaggaggtaa 76981 ggaatgaatc gggtcttccg taataccatt ttttatttac ttattttatt agtagtaatc 77041 ggggttgtga gctacttcca gacctcaaat ccgaaaacag aaaatatgtc gtacagtacg 77101 ttcatcaaaa acctggatga cgggaaagtt gatagcgtat cggttcagcc tgtcagaggt 77161 gtttatgagg taaaagggca gctgaaaaac tacgacaaag atcaatactt tttgactcat 77221 gttcctgaag gaaagggagc agaccagata tttaacgctt tgaaaaagac agacgtaaag 77281 gttgagcccg cgcaagaaac aagcggatgg gtgacgttcc tgacgaccat catcccattt 77341 gtcattatct ttattctgtt tttcttcctg ctcaatcagg ctcaaggcgg cggcagccgt 77401 gtcatgaact ttggcaagag taaagcgaag ctgtatacag aggaaaagaa acgcgtcaaa 77461 tttaaagacg ttgcaggggc tgacgaagaa aagcaagaac ttgttgaagt tgttgagttt 77521 ctgaaagatc cccgcaagtt tgccgagctc ggcgccagaa taccgaaagg cgtgctttta 77581 gtcggacctc cgggtaccgg taaaacattg cttgccaagg cttgtgcagg agaagccggc 77641 gtacctttct tcagcatcag cggatctgat ttcgttgaaa tgtttgtagg ggtcggtgct 77701 tcccgtgtgc gtgacttgtt tgaaaatgcg aaaaagaatg cgccttgttt gatcttcatt 77761 gatgaaattg acgcagtcgg acgccagcgt ggcgctggtc tcggcggtgg acacgatgaa 77821 cgtgaacaga cgctaaacca attgcttgtt gaaatggacg gattcagcgc taatgaagga 77881 attatcatca ttgctgcgac gaaccgtgcg gacatcttgg acccagcctt acttcgtccg 77941 ggacgttttg accgtcaaat cacagtggac cgcccagatg tcattggccg tgaagctgta 78001 ttgaaagtcc atgcgagaaa caaaccgctg gatgaaacgg ttaacctaaa atcaattgcc 78061 atgagaacac caggcttctc aggcgctgac ttagaaaacc tcttgaatga agctgcgctt 78121 gtagcggctc gtcaaaacaa gaaaaaaatc gatgcgcgtg atattgacga agcgacggac 78181 cgtgtaattg ccggacccgc taagaagagc cgcgttatct ccaagaaaga acgcaatatc 78241 gtggcttatc acgaaggcgg acacaccgtt atcggtctcg ttttagatga ggcagatatg 78301 gttcataaag taacgattgt tcctcggggc caggctggcg gttatgctgt tatgctgcca 78361 agagaagacc gttatttcca aacaaagccg gagctgcttg ataaaattgt cggcctcttg 78421 ggcggacgtg ttgctgaaga gattatcttc ggtgaagtca gcacaggggc gcacaatgac 78481 ttccagcgtg cgacgaatat tgcaagacga atggttacag aattcggtat gtcagaaaaa 78541 ctgggaccgt tgcaatttgg acagtctcag ggcggtcagg tattcttagg ccgtgatttc 78601 aacaacgaac agaactacag tgatcaaatc gcttacgaaa ttgatcagga aattcagcgc 78661 atcatcaaag aatgttatga gcgtgcgaaa caaatcctga ctgaaaatcg tgacaagctt 78721 gaattgattg cccaaacgct tctgaaagtt gaaacgcttg acgctgaaca aatcaaacac 78781 cttatcgatc atggaacatt acctgagcgt aatttctcag atgatgaaaa gaacgatgat 78841 gtgaaagtaa acattctgac aaaaacagaa gaaaagaaag acgatacgaa agagtaattc 78901 gctttctttc taaaaaaact gccggctgac gctggcagtt tttttatgta aatgattggc 78961 tcagctgcgg cttttacaat catccaattc tggtatcgat ttgtttacaa atgagccgct 79021 gatcgtgtat ggtattgtag aatgtttgta aaaagtaaag tagagaaact attcaaaagt 79081 ggtgatagag gttgttactg gttatcgatg tggggaacac caatactgta cttggtgtat 79141 atcatgatgg aaaattagaa tatcactggc gtatagaaac aagcaggcat aaaacagaag 79201 atgagtttgg gatgattttg cgctccttat ttgatcactc cgggcttatg tttgaacaga 79261 tagatggcat tattatttcg tcagtagtgc cgccaatcat gtttgcgtta gaaagaatgt 79321 gcacaaaata ctttcatatc gagcctcaaa ttgttggtcc aggtatgaaa accggtttaa 79381 atataaaata tgacaatccg aaagaagtag gggcagacag aatcgtaaat gctgtcgctg 79441 cgatacactt gtacggcaat ccattaattg ttgtcgattt cggaaccgcc acaacgtact 79501 gctatattga tgaaaacaaa caatacatgg gcggggcgat tgcccctggg attacaattt 79561 cgacagaggc gctttactcg cgtgcagcaa agcttcctcg tatcgaaatc acccggcccg 79621 acaatattat cggaaaaaac actgttagcg cgatgcaatc tggaatttta tttggctatg 79681 tcggccaagt ggaaggaatc gttaagcgaa tgaaatggca ggcaaaacag gaaccaaagg 79741 tcattgcgac aggaggcctg gcgccgctca ttgcgaacga atcagattgt atagacatcg 79801 ttgatccatt cttaacccta aaagggctgg aattgattta tgaaagaaac cgcgtaggaa 79861 gtgtatagga ggtttagtaa tggattattt agtaaaagca cttgcgtatg acggaaaagt 79921 tcgggcttat gcagcgagaa cgactgatat ggtaaatgag gggcagagac gccatggtac 79981 gtggccgaca gcatccgctg cactaggccg tacaatgaca gcttcactta tgctcggcgc 80041 tatgctgaag ggcgatgata agctgaccgt gaaaatcgag ggcggaggtc cgatcggagc 80101 tattgtagct gatgccaatg ccaaaggaga agtcagagcc tatgtctcta acccgcaagt 80161 tcattttgat ttaaatgaac aaggtaagct tgatgtcaga cgtgcggttg gaacaaacgg 80221 aacgttaagt gtcgtaaaag atttaggttt gcgcgagttc ttcacaggac aagtagaaat 80281 cgtttcagga gaattaggag atgattttac ttactatctt gtgtcatctg agcaggttcc 80341 ttcatcagtg ggcgtaggtg tgctcgtaaa tcctgacaat accattcttg cggcaggggg 80401 ctttattatt cagctgatgc cgggaacaga tgatgaaaca atcacaaaaa ttgaacagcg 80461 tctatctcaa gtagagccga tttctaagct catccaaaaa gggctgacac cagaagaaat 80521 tttagaagaa gtcctaggcg agaaacctga gattttggaa acgatgcctg tcagattcca 80581 ttgcccttgt tcaaaagaac ggttcgaaac agccatttta ggactaggca aaaaagaaat 80641 tcaagatatg atagaagaag atggacaagc cgaagcagta tgccattttt gtaatgaaaa 80701 gtacttattt acaaaagaag agctggaagg gcttcgtgac caaactaccc gctaagctct 80761 ttagcgggtt tttaatttga gaaaaggggc tgaaagcagg tttgaaatca agaacaatct 80821 ggaccattat tttaggggcg ctgttggttt gctgtattgc tgttgcatat acgctgacga 80881 aatcccaagc cggcgcatcg tcatccggtg agtctattgc gactatcgga ggcaagagtg 80941 tgacaagaga agaatggctg aaagaaatgg aagatcagta tggtaagtca acgcttgaag 81001 atatgatcaa tgtccgagtt gttgagcagc tggctaaaaa gaacaaactt aaaatatcca 81061 aaagcgaagt tgatcgtgag tttttgctga ttaaagcggt caataattcc ttttacgaag 81121 atgaacatac gacggagaaa gagtggaaag accaaattcg ttataatatc ctccttgagg 81181 atttgttaac aagggatatc gatatctcaa acaaagaatt ggaatcattc tataataaaa 81241 ataaggaact atatcagttt gatgattcgt atcgaattcg gcacattgtt gtaaaagatg 81301 aagaagaagc aagagaagtc ctgaaagaac tgaaaggcgg atcaagcttt gaagctgtcg 81361 ctgccgaaag atctacagac agatatacat caccatacgg cggagattta ggttttgtca 81421 cagaggcatc agacaacatt ccatcagcat acattgaaga ggcgaaaaca ctcaaagagg 81481 atgaatggtc tcaggaacca ataaaggtca gcaacggata tgccattatc cagctgaaag 81541 aaaaactaaa ggcaagaacg ttctcatttg atgaagtaaa ggaccagatc agacggcaaa 81601 tcgcaatgga tcagctaggc gataaagcga cagttaagac actttggaaa gaagccgatg 81661 tatcttggtt ttatggggaa aaaagtacta agtgattgac aaaaaatttt gaaattgata 81721 gattatatac ataataccaa tacaaatagt cggaaattga ggtgtcgaga atggtacgtg 81781 tagcaaactc cattactgaa ttaattggga atacgccaat cgttaaatta aatcgccttg 81841 cagatgaaaa cagtgcggat gtatatctaa aacttgaata catgaaccct ggaagcagtg 81901 taaaagaccg tatcggttta gctatgattg aagcggctga aaaagaagga aaattaaaag 81961 ccggtaatac aatcattgaa ccgacaagcg gaaatactgg aatcgggctt gcaatggttg 82021 ctgctgctaa aggattaaaa gccattttgg ttatgcctga tacaatgagc atggagcgcc 82081 gcaaccttct tcgcgcatat ggtgctgagc ttgtgctgac tcctggtgcg gaaggcatga 82141 aaggtgctat taagaaagct gaagagcttg ctgaaaagca cggatacttt gtgccgcagc 82201 agtttaacaa cccttctaac cccgaaattc accgccaaac aacgggtaaa gaaatcgttg 82261 agcaattcgg tgatgatcag cttgacgcat ttgtagccgg aatcggaacg ggcggaacga 82321 ttacgggagc gggcgaagtg ctgaaggaag catacccttc catcaagatt tatgctgttg 82381 aaccgtcaga ttccccagtg ctttcaggag gaaaaccagg cccccacaaa attcagggaa 82441 tcggagcagg attcgtgccg gacatcttaa acactgaagt atatgatgaa atcttccctg 82501 tgaagaatga agaagcattc gaatatgccc gcagagctgc acgtgaagaa ggaattctcg 82561 gaggcatctc atcaggtgcg gcaatttatg ctgctcttca agtagcaaaa aaactcggaa 82621 aaggcaaaaa agtattggcc atcattccaa gtaacggcga acgttatcta agcacgccgc 82681 tgtaccaatt cgattaaaaa aagccaaaac tcccggttcg ccgggagttt ttttatattt 82741 cgtgcatcaa atatgccatg tctgcgacga atgttattct tggaagagaa attcactttt 82801 ttcactaaca acattgcttt acaattaaaa acaagtaaaa aagaaaatag aggaatgata 82861 caaatggcac aacgcagacc ggcaggcaaa aaaatacctt ttcaaaaaga ctcattctta 82921 caacaatttg agaaacttgc gcaatcccgg aaacatcatg tacttctcga aagtgcaaga 82981 ggcggcagat atagtatagc cggtcttgat ccaattgcga ctgtgaaagg aaaagacgga 83041 ataactacaa ttaagcatgg tgatgagatg ctgtttaaag aaggtgatcc attacgggcc 83101 ttccacagct ggtttaaaac actggaaaca gaaacgaatc atgagttccc tgactttcaa 83161 ggcggggcaa tcgggtttct cagctatgat tacgcacggt acattgaaaa ttttaaaatg 83221 ctctcattag atgatttaga aacaccagat atttattttc ttgtttttga tgatatagca 83281 gtttatgacc atcaagaaga gtctctatgg ctgattactc atgttaatgg ttctgatcag 83341 gaaacagcgg atgtgaagct atctgagtta gagcagatgt ggttgactga gcttcccgct 83401 gtcacttcgc gagagatgaa gcctgaaaca gctggttctt tcgcggcgcc atttaccgag 83461 gatgggttct cacaagctgt agagaaaatc aaacaataca ttgccagcgg agatgtgttt 83521 caagtcaatc tatcaataag gcagtcacag tcactgtctg tccacccata tcaaatttac 83581 aaaaccttga gagaagtaaa tccttctcct tatatggcgt atttagaaac acctgatttc 83641 caaatcattt gcggatcgcc tgaactgctt gtcagcaaaa agggcaagct attagagacg 83701 agaccgattg cgggcacccg ttccagaggg aaaacaaatg aagaagacga ggcgcttgca 83761 aacgaattga tacacaatga aaaagaacgc gcggaacatg tcatgctggt tgatcttgag 83821 cgaaatgatc tgggaagagt atcacgttac gggtctgtgc gcgtaaatga attcatggca 83881 attgaaaaat actcgcatgt gatgcacatt gtgtctaatg tccaaggtga actgcaggat 83941 gggtatgatg ctgtagatat tattcatgct gtgtttcccg gaggaaccat tactggtgca 84001 ccgaaagtaa gaacgatgga aattatagaa gaacttgagc cgacacgccg agggctttat 84061 actggatcta taggatggtt tggatataat cacgatctgc agtttaatat cgtcattcga 84121 accatttatg caaccggagg gcaggcattt atgcagtccg gtgcaggagt tgtgattgat 84181 tctgttccga agcacgaata caaggaatca ttcaaaaaag cttttgcgat gcaaagagca 84241 ttagagctga gcgaagaaga gacaaaaatt agatgaggtg agcggagaaa tgattttaat 84301 gattgataac tacgattcat tcacgtacaa cttggtacag tatttgggcg agcttgggga 84361 agagctggtt gtgaaacgca atgacagcat cacaatcgat gaaattgaag aactgtctcc 84421 ggactttctg atgatatctc ccggaccgtg cagccctgat gaggcgggaa tcagcctcga 84481 agcaattaaa catttcgcag ggaaaattcc tattttcggt gtatgtctcg gacatcagtc 84541 catcgcacaa gtgttcggtg gtgatgttgt tagggcagaa cggcttatgc acgggaaaac 84601 ctcggatatc gagcatgacg gcaaaaccat ttttgaaggg ttgaaaaatc cccttgttgc 84661 gacgcgatac cactcgctga tcgtaaaacc tgagacgctg ccaagctgtt ttacagtaac 84721 agcacaaacg aaagaaggag aaatcatggc tattcgccac aatgacctcc cgatagaggg 84781 tgtgcaattt cacccagagt ctattatgac ctcctttggg aaagaaatgc tcagaaattt 84841 tattgagaca tatcgcaagg aagttattgc gtgatgatat atgtgaacgg ccggtatatg 84901 gaggagaaag atgcagttct ttctcctttt gaccatgggt ttttatatgg gatcggtgtt 84961 ttcgaaacct tcaggctcta cgaaggctgc ccgtttttgc ttgattggca tatagagagg 85021 cttgaacgcg cgcttaagga tctgcaaatc gaatatactg tttcaaagca tgagatcctt 85081 gagatgctgg acaagctgct taagctaaat gatatcaagg atggcaatgc ccgcgtcaga 85141 ctgaacatat cagcgggaat cagcgataaa ggctttgtcg cccagacgta cgataagccc 85201 accgttttat gctttgtgaa tcagctgaaa ccagaaagtc ttcctttgca aaaagaagga 85261 aaggttttat cgatacggag aaacactcca gagggatcgt tccggttaaa atctcatcat 85321 tatctaaata atatgtatgc gaaacgggaa attggaaatg atccgcgtgt cgagggaatt 85381 ttcttaacgg aggatggagc tgttgcagag ggtatcatat ctaatgtctt ctggagaaaa 85441 ggtcgctgta tctatacgcc atcgcttgat accggtattc tggacggcgt cacgagacgt 85501 tttatcatag aaaatgcaaa ggatatcggc ctggagctca aaacgggccg atatgagcta 85561 gaagctctct tgacagctga cgaagcgtgg atgacgaact cggttcttga aatcatcccg 85621 tttactaaaa tagaagaagt aaactatgga agccaaagcg gagaagcaac ctccgctctt 85681 caattgttat acaaaaaaga aataaagaac atgattcatg aaaagggagg aagagcatgg 85741 cgcagcacac aatagatcaa acacaagtaa tccacactaa gcccagcgct ttatcatata 85801 aagagaagac gctggtgatg ggaattttaa acgtaacgcc tgactctttc tcggacggcg 85861 gaaaatatga cagcttggac aaggcgctgc tgcacgcgaa agagatgatc gatgatggtg 85921 cccatatcat tgatattgga ggggaatcga caaggcctgg cgctgagtgc gtatctgagg 85981 atgaggagat gtccagagtc attccggtga ttgagcggat tacgaaagag cttggtgttc 86041 ctatttctgt agacacgtac aaggcttctg tcgcagatga agcagtgaaa gccggtgcat 86101 ccattatcaa tgatatttgg ggagccaaac atgatccgaa gatggcttcc gttgcagctg 86161 aacataatgt tccaattgta ctcatgcata accgccctga aagaaactac aatgacttat 86221 tgccggatat gctgtcggac ttaatggaga gtgtaaaaat tgctgttgag gccggagtag 86281 acgagaagaa cattattctt gatcctggta tcggtttcgc gaaaacctat cacgataact 86341 tggcagtgat gaacaaacta gagattttca gcggattggg atatccggtt cttctggcaa 86401 cctcccgaaa aagattcatc ggacgtgttc tggatcttcc gcctgaggag cgggctgagg 86461 gcacaggcgc gactgtgtgt ctcggcattc aaaaaggctg tgacattgtc agggtccatg 86521 atgtaaagca aattgccaga atggcgaaaa tgatggacgc gatgctgaat aagggagggg 86581 tgcaccatgg ataaagttta tgtagaaggt atggagtttt acggatatca cggtgtgttc 86641 acagaagaaa acaaacttgg ccagcggttt aaagtcgatt taaccgctga gctggattta 86701 agcaaagctg gacagacaga cgaccttgag caaacgatca actatgctga gctctatcac 86761 gtatgtaaag atatcgtgga aggggagcct gtgaaattgg tggaaacgct ggcggaacgt 86821 attgctggca ctgttctcgg aaaatttcag cctgttcagc aatgtacggt gaaagtgatt 86881 aagccagacc cgccaattcc cggacactat aaatcagtag caattgaaat tacgagaaaa 86941 aagtcatgaa caacatagct tatattgcac ttggatctaa tattggagat agagaaacgt 87001 atttaaggca agcagtggct ttactgcatc agcatgctgc ggtgacagtc actaaagtgt 87061 cgtctattta cgaaactgac ccggtcggat acgaagatca agctcaattt ttgaatatgg 87121 ctgttgaaat caagacatca ttgaaccctt ttgaactcct tgaactgacg cagcagatag 87181 aaaatgaatt aggcagaaca agggaagtaa gatgggggcc gcggacggca gaccttgaca 87241 ttttgttatt taatcgtgaa aatattgaaa cagagcaact aattgttccg catccgagaa 87301 tgtatgagcg tttgtttgtc cttgcgccgc ttgcggaaat ttgccagcag gttgaaaaag 87361 aggctacaag cgccgaaaca gaccaagaag gtgtaagagt atggaagcag aaatctgggg 87421 tagacgaatt cgtgcattca gaaagctgaa aggttatact caagaaggat ttgcaaaagc 87481 attaggtata tcagtttcta ttctcggcga aattgaacgc ggaaaccgat tgccgtctgc 87541 tgccatcatt caagatgcag cagatgtttt aaatataagt gcggacgaat tggcgccgcc 87601 agaaaaatag aacaaatgaa aggaggagaa aaattgttca aaatcggaga tattcaattg 87661 aaaaaccggg ttgtgctcgc acctatggct ggtgtctgca actctgcgtt cagattgact 87721 gtaaaggaat tcggagccgg attggtatgc gctgaaatgg tcagtgacaa agcgatcctt 87781 tacaacaatg caagaacaat gggtatgctt tatattgatg aacgtgagaa accactgagc 87841 cttcaaattt tcggaggaaa aaaggaaacc cttgtggaag cggcgaagtt tgtagaccaa 87901 aacacaactg ctgatatcat tgatattaac atgggatgtc ccgtgccgaa gattacaaaa 87961 tgcgatgcgg gagccaaatg gcttctcgat cctgataaga tttacgaaat ggtttctgca 88021 gtagtggatg ctgttaataa gccagttaca gtgaaaatga gaatgggctg ggatgaagac 88081 cacattttcg cagtgaaaaa tgcacaggct gtagaacgtg cgggcggtaa agcagtggcg 88141 cttcacggcc gtacgagagt gcagatgtac gaaggaacgg caaactggga tatcatcaaa 88201 gaagtaaaac aatcagtatc gattccggtt atcggaaacg gcgatgttaa gacaccgcag 88261 gatgctaagc gtatgctcga tgagacagga gtagacgggg tcatgatcgg acgcgctgca 88321 ttgggtaacc cgtggatgat ttaccgtacg gttcagtatc ttgaaacagg taaattaaaa 88381 gaagagccgc aagtacgcga aaaaatggcc gtatgcaaac tgcatcttga ccgcctgatt 88441 gacttaaaag gtgaaaacgt agcggtaaga gaaatgagaa agcacgctgc atggtatctg 88501 aaaggcgtga aaggcaatgc gaacgttcgt aatgaaatca atcattgcga gacgagagaa 88561 gagtttgtac agcttttaga tgcatttacg gttgaagttg aggcaaaaga gcttcaaaat 88621 gcaaaagtag gataatactc acctctattt gctgctcact gctagtttta cgctggcagt 88681 ttttctgctt ttttcatgaa acaatatctg taatggagtg ataacaatga gtcaagaaga 88741 gcataaccat gaagaattga atgatcagct gcaagtcaga cgcgataaaa tgaatcagct 88801 gagagataac ggcatcgatc cattcggcgc acgttttgaa agaactcatc agtctcaaga 88861 agttatttcg gcatatcaag atctaaccaa agaagagtta gaagaaaaag cgattgaagt 88921 tacaatcgca ggccgcatga tgacaaaacg cggcaaagga aaagccggct ttgcccatct 88981 tcaggattta gaaggccaaa tccaaatcta cgtaagaaaa gacagtgtcg gtgacgacca 89041 atatgaaatc ttcaagtctt ctgacctcgg tgatcttatc ggcgtaaccg gaaaagtctt 89101 caaaacaaat gtaggcgaat tgtctgttaa agcaacttcc tttgaattgc tgacaaaagc 89161 gcttcgtccg cttcctgaca aataccatgg tttaaaagac gttgagcagc gctaccgtca 89221 gcgctatctg gatcttatcg taaacccaga cagcaaacat acgttcatta cacgaagcaa 89281 gatcattcaa gctatgagaa ggtaccttga tgatcatgga tacttagaag tagaaacacc 89341 tacaatgcac agcattcctg ggggagcttc tgcacgtccg tttatcactc accacaacgc 89401 gttagacatt ccactctata tgcgtattgc tatcgaactg cacctaaaac gtctaattgt 89461 cggcggttta gaaaaagtat atgaaatcgg ccgtgttttc cgtaacgaag gtgtctctac 89521 acgccataac cctgaattta caatgattga gttatatgaa gcatatgcgg actataaaga 89581 tatcatgagc ttaactgaaa accttgtcgc tcatatcgcc caagaagtgc ttggcacaac 89641 tacgattcaa tacggggaag agcaaatcga ccttaaaccg gagtggaaaa gaatccatat 89701 ggttgacgca gtcaaagaag cgaccggcgt tgatttctgg gaagaggtta ctgttgagca 89761 ggcgcgtgaa tatgcaaaag aacatgaagt agaaattaaa gactctatga cagtaggcca 89821 tatcatcaac gaattcttcg aacaaaaaat tgaagaaacg cttattcagc caacgtttat 89881 ttacgggcat cctgtagaaa tttctcctct tgctaagaaa aaccctgagg acccgcgttt 89941 tacagaccgt tttgagctgt ttatcgttgg ccgtgaacat gccaacgcgt ttacagagct 90001 gaatgatcct attgatcaaa gagaacgctt tgaagcgcaa ttaaaagagc gtgaagccgg 90061 taatgatgaa gctcatttaa tggatgaaga ctttgttgaa gctctggaat acggtatgcc 90121 gccaacagga ggtttaggca tcggtatcga ccgtctggtt atgctgctga cgaatgcccc 90181 ttctattcgc gatgtgctgt tattcccgca aatgagacaa cgctaataaa aaagagcggt 90241 atcctccata gggaaaggat gccgctcttt ttaaatccct tagtatttct tcaaaaaaac 90301 tattgcacta ttatttacta ggtggtatat tattattcgt tgccgctaaa caaggcgata 90361 acgaaaaaaa gaacttcaaa aaaagttatt gacttcactg agtcaacgag ttataataat 90421 aaagtcgctt gaacgaagtg aacaaaatga tctttgaaaa ctaaacaaga caaaacgtac 90481 ctgttaattc agtttttaaa aatcgcacag cgatgtgcgt agtcagtcaa actactttat 90541 cggagagttt gatcctggct caggacgaac gctggcggcg tgcctaatac atgcaagtcg 90601 agcggacaga tgggagcttg ctccctgatg ttagcggcgg acgggtgagt aacacgtggg 90661 taacctgcct gtaagactgg gataactccg ggaaaccggg gctaataccg gatggttgtt 90721 tgaaccgcat ggttcaaaca taaaaggtgg cttcggctac cacttgcaga tggacccgcg 90781 gcgcattagc tagttggtga ggtaatggct caccaaggca acgatgcgta gccgacctga 90841 gagggtgatc ggccacactg ggactgagac acggcccaga ctcctacggg aggcagcagt 90901 agggaatctt ccgcaatgga cgaaagtctg acggagcaac gccgcgtgag tgatgaaggt 90961 tttcggatcg taaagctctg ttgttaggga agaacaagtg ccgttcgaat agggcggtac 91021 cttgacggta cctaaccaga aagccacggc taactacgtg ccagcagccg cggtaatacg 91081 taggtggcaa gcgttgtccg gaattattgg gcgtaaaggg ctcgcaggcg gtttcttaag 91141 tctgatgtga aagcccccgg ctcaaccggg gagggtcatt ggaaactggg gaacttgagt 91201 gcagaagagg agagtggaat tccacgtgta gcggtgaaat gcgtagagat gtggaggaac 91261 accagtggcg aaggcgactc tctggtctgt aactgacgct gaggagcgaa agcgtgggga 91321 gcgaacagga ttagataccc tggtagtcca cgccgtaaac gatgagtgct aagtgttagg 91381 gggtttccgc cccttagtgc tgcagctaac gcattaagca ctccgcctgg ggagtacggt 91441 cgcaagactg aaactcaaag gaattgacgg gggcccgcac aagcggtgga gcatgtggtt 91501 taattcgaag caacgcgaag aaccttacca ggtcttgaca tcctctgaca atcctagaga 91561 taggacgtcc ccttcggggg cagagtgaca ggtggtgcat ggttgtcgtc agctcgtgtc 91621 gtgagatgtt gggttaagtc ccgcaacgag cgcaaccctt gatcttagtt gccagcattc 91681 agttgggcac tctaaggtga ctgccggtga caaaccggag gaaggtgggg atgacgtcaa 91741 atcatcatgc cccttatgac ctgggctaca cacgtgctac aatggacaga acaaagggca 91801 gcgaaaccgc gaggttaagc caatcccaca aatctgttct cagttcggat cgcagtctgc 91861 aactcgactg cgtgaagctg gaatcgctag taatcgcgga tcagcatgcc gcggtgaata 91921 cgttcccggg ccttgtacac accgcccgtc acaccacgag agtttgtaac acccgaagtc 91981 ggtgaggtaa ccttttagga gccagccgcc gaaggtggga cagatgattg gggtgaagtc 92041 gtaacaaggt agccgtatcg gaaggtgcgg ctggatcacc tcctttctaa ggatatttta 92101 cggaatataa gaccttgggt cttataaaca gaacgttccc tgtcttgttt agttttgaag 92161 gatcattcct tcgaaacgtg ttctttgaaa actagataac agtagacatc acattcaagt 92221 aatacaagat atcacatagt gattcttttt aacggttaag ttagaaaggg cgcacggtgg 92281 atgccttggc actaggagcc gatgaaggac gggacgaaca ccgatatgct tcggggagct 92341 gtaagcaagc tttgatccgg agatttccga atggggaaac ccaccactcg taatggagtg 92401 gtatccatat ctgaattcat aggatatgag aaggcagacc cggggaactg aaacatctaa 92461 gtacccggag gaagagaaag caaatgcgat tccctgagta gcggcgagcg aaacgggatt 92521 agcccaaacc aagaggcttg cctcttgggg ttgtaggaca ctctgtacgg agttacaaag 92581 gaacgaggta gatgaagagg tctggaaagg cccgccatag gaggtaacag ccctgtagtc 92641 aaaacttcgt tctctcctga gtggatcctg agtacggcgg aacacgtgaa attccgtcgg 92701 aatccgggag gaccatctcc caaggctaaa tactccctag tgaccgatag tgaaccagta 92761 ccgtgaggga aaggtgaaaa gcaccccgga aggggagtga aagagatcct gaaaccgtgt 92821 gcctacaagt agtcagagcc cgttaacggg tgatggcgtg ccttttgtag aatgaaccgg 92881 cgagttacga tcccgtgcaa ggttaagcag aagatgcgga gccgcagcga aagcgagtct 92941 gaatagggcg catgagtacg tggtcgtaga cccgaaacca ggtgatctac ccatgtccag 93001 ggtgaagttc aggtaacact gaatggaggc ccgaacccac gcacgttgaa aagtgcgggg 93061 atgaggtgtg ggtaggggtg aaatgccaat cgaacctgga gatagctggt tctctccgaa 93121 atagctttag ggctagcctc aaggtaagag tcttggaggt agagcactga ttggactagg 93181 ggcccctacc gggttaccga attcagtcaa actccgaatg ccaatgactt atccttggga 93241 gtcagactgc gagtgataag atccgtagtc gaaagggaaa cagcccagac cgccagctaa 93301 ggtcccaaag tatacgttaa gtggaaaagg atgtggagtt gcttagacaa ccaggatgtt 93361 ggcttagaag cagccaccat ttaaagagtg cgtaatagct cactggtcga gtgactctgc 93421 gccgaaaatg taccggggct aaacgtatca ccgaagctgc ggactgttct tcgaacagtg 93481 gtaggagagc gttctaaggg ctgtgaagcc agaccggaag gactggtgga gcgcttagaa 93541 gtgagaatgc cggtatgagt agcgaaagag gggtgagaat cccctccacc gaatgcctaa 93601 ggtttcctga ggaaggctcg tccgctcagg gttagtcggg acctaagccg aggccgaaag 93661 gcgtaggcga tggacaacag gttgatattc ctgtaccacc tcctcaccat ttgagcaatg 93721 gggggacgca ggaggatagg gtaagcgcgg tattggatat ccgcgtccaa gcagttaggc 93781 tgggaaatag gcaaatccgt ttcccataag gctgagctgt gatggcgagc gaaatatagt 93841 agcgaagttc ctgattccac actgccaaga aaagcctcta gcgaggtgag aggtgcccgt 93901 accgcaaacc gacacaggta ggcgaggaga gaatcctaag gtgatcgaga gaactctcgt 93961 taaggaactc ggcaaaatga ccccgtaact tcgggagaag gggtgctctg ttagggtgca 94021 agcccgagag agccgcagtg aataggccca ggcgactgtt tagcaaaaac acaggtctct 94081 gcgaagccgt aaggcgaagt ataggggctg acgcctgccc ggtgctggaa ggttaagagg 94141 agcgcttagc gtaagcgaag gtgcgaattg aagccccagt aaacggcggc cgtaactata 94201 acggtcctaa ggtagcgaaa ttccttgtcg ggtaagttcc gacccgcacg aaaggcgcaa 94261 cgatctgggc actgtctcaa cgagagactc ggtgaaatta tagtacctgt gaagatgcag 94321 gttacccgcg acaggacgga aagaccccgt ggagctttac tgcagcctga tattgaatgt 94381 tggtacagct tgtacaggat aggtaggagc cttggaaacc ggagcgccag cttcggtgga 94441 ggcatcggtg ggatactacc ctggctgtat tgaccttcta acccgccgcc cttatcgggc 94501 ggggagacag tgtcaggtgg gcagtttgac tggggcggtc gcctcctaaa aggtaacgga 94561 ggcgcccaaa ggttccctca gaatggttgg aaatcattcg cagagtgtaa aggcacaagg 94621 gagcttgact gcgagaccta caagtcgagc agggacgaaa gtcgggctta gtgatccggt 94681 ggttccgcat ggaagggcca tcgctcaacg gataaaagct accccgggga taacaggctt 94741 atctccccca agagtccaca tcgacgggga ggtttggcac ctcgatgtcg gctcatcgca 94801 tcctggggct gtagtcggtc ccaagggttg ggctgttcgc ccattaaagc ggtacgcgag 94861 ctgggttcag aacgtcgtga gacagttcgg tccctatccg tcgcgggcgc aggaaatttg 94921 agaggagctg tccttagtac gagaggaccg ggatggacgc accgctggtg taccagttgt 94981 tctgccaagg gcatcgctgg gtagctatgt gcggacggga taagtgctga aagcatctaa 95041 gcatgaagcc cccctcaaga tgagatttcc cattccgcaa ggaagtaaga tccctgaaag 95101 atgatcaggt tgataggtct gaggtggaag tgtggcgaca catggagctg acagatacta 95161 atcgatcgag gacttaacca tatttttgaa tgatgtcaca tctgttatct agttttgaga 95221 gaacactctc aatttgtttg gtggcgatag cgaagaggtc acacccgttc ccataccgaa 95281 cacggaagtt aagctcttca gcgccgatgg tagtcggggg tttccccctg tgagagtagg 95341 acgccgccaa gcaattgcac gttagtgcaa ttatggagga ttagctcagc tgggagagca 95401 tctgccttac aagcagaggg tcggcggttc gagcccgtca tcctccacca ttatgccggt 95461 gtagctcaat tggtagagca actgacttgt aatcagtagg ttgggggttc aagtcctctt 95521 gccggcacca cttttatatg atataatact caagtctctt gtagaagagc cattagctca 95581 gttggtagag catctgactt ttaatcagag ggtcgaaggt tcgagtcctt catggctcac 95641 cattttacgc gggtgtggcg gaattggcag acgcgctaga cttaggatct agtgtcttta 95701 tgacgtgggg gttcaagtcc cttcacccgc attatatagg ataacagtta gaaaaactgg 95761 acatcctgtc tgcggaagta gttcagtggt agaacaccac cttgccaagg tgggggtcgc 95821 gggttcgaat cccgtcttcc gctccaacta taccatccac gccggggtgg tggaattggc 95881 agacacacag gacttaaaat cctgcggtag gtgactaccg tgccggttca agtccggccc 95941 tcggcattat gttttgcgcc cgtagctcaa ttggatagag cgtttgacta cggatcaaaa 96001 ggttaggggt tcgactcctc tcgggcgcgc catatctttt aatagaatag ataggaaatc 96061 gggaagtagc tcagcttggt agagcacatg gtttgggacc atggggtcgc aggttcgaat 96121 cctgtcttcc cgaccatttt tttatggggc cttagctcag ctgggagagc gcctgctttg 96181 cacgcaggag gtcagcggtt cgatcccgct aggctccacc aaaagttttt aaaaaagttg 96241 ttgactttga agaagtgacg ttgtatacta ataaagttgc tttaacaaag cggacaaaca 96301 aaatgatctt tgaaaactaa acaagacaaa acgtacctgt taattcagtt tttaaaaatc 96361 gcacagcgat gtgcgtagtc agtcaaacta ctttatcgga gagtttgatc ctggctcagg 96421 acgaacgctg gcggcgtgcc taatacatgc aagtcgagcg gacagatggg agcttgctcc 96481 ctgatgttag cggcggacgg gtgagtaaca cgtgggtaac ctgcctgtaa gactgggata 96541 actccgggaa accggggcta ataccggatg gttgtttgaa ccgcatggtt caaacataaa 96601 aggtggcttc ggctaccact tacagatgga cccgcggcgc attagctagt tggtgaggta 96661 acggctcacc aaggcaacga tgcgtagccg acctgagagg gtgatcggcc acactgggac 96721 tgagacacgg cccagactcc tacgggaggc agcagtaggg aatcttccgc aatggacgaa 96781 agtctgacgg agcaacgccg cgtgagtgat gaaggttttc ggatcgtaaa gctctgttgt 96841 tagggaagaa caagtaccgt tcgaataggg cggtaccttg acggtaccta accagaaagc 96901 cacggctaac tacgtgccag cagccgcggt aatacgtagg tggcaagcgt tgtccggaat 96961 tattgggcgt aaagggctcg caggcggttt cttaagtctg atgtgaaagc ccccggctca 97021 accggggagg gtcattggaa actggggaac ttgagtgcag aagaggagag tggaattcca 97081 cgtgtagcgg tgaaatgcgt agagatgtgg aggaacacca gtggcgaagg cgactctctg 97141 gtctgtaact gacgctgagg agcgaaagcg tggggagcga acaggattag ataccctggt 97201 agtccacgcc gtaaacgatg agtgctaagt gttagggggt ttccgcccct tagtgctgca 97261 gctaacgcat taagcactcc gcctggggag tacggtcgca agactgaaac tcaaaggaat 97321 tgacgggggc ccgcacaagc ggtggagcat gtggtttaat tcgaagcaac gcgaagaacc 97381 ttaccaggtc ttgacatcct ctgacaatcc tagagatagg acgtcccctt cgggggcaga 97441 gtgacaggtg gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt taagtcccgc 97501 aacgagcgca acccttgatc ttagttgcca gcattcagtt gggcactcta aggtgactgc 97561 cggtgacaaa ccggaggaag gtggggatga cgtcaaatca tcatgcccct tatgacctgg 97621 gctacacacg tgctacaatg gacagaacaa agggcagcga aaccgcgagg ttaagccaat 97681 cccacaaatc tgttctcagt tcggatcgca gtctgcaact cgactgcgtg aagctggaat 97741 cgctagtaat cgcggatcag catgccgcgg tgaatacgtt cccgggcctt gtacacaccg 97801 cccgtcacac cacgagagtt tgtaacaccc gaagtcggtg aggtaacctt ttaggagcca 97861 gccgccgaag gtgggacaga tgattggggt gaagtcgtaa caaggtagcc gtatcggaag 97921 gtgcggctgg atcacctcct ttctaaggat attttacgga atataagacc ttgggtctta 97981 taaacagaac gttccctgtc ttgtttagtt ttgaaggatc attccttcga aacgtgttct 98041 ttgaaaacta gataacagta gacatcacat tcaagtaata caagatatca catagtgatt 98101 ctttttaacg gttaagttag aaagggcgca cggtggatgc cttggcacta ggagccgatg 98161 aaggacggga cgaacaccga tatgcttcgg ggagctgtaa gcaagctttg atccggagat 98221 ttccgaatgg ggaaacccac cactcgtaat ggagtggtat ccatatctga attcatagga 98281 tatgagaagg cagacccggg gaactgaaac atctaagtac ccggaggaag agaaagcaaa 98341 tgcgattccc tgagtagcgg cgagcgaaac gggatcagcc caaaccaaga ggcttgcctc 98401 ttggggttgt aggacactct gtacggagtt acaaaggaac gaggtagatg aagaggtctg 98461 gaaaggcccg ccataggagg taacagccct gtagtcaaaa cttcgttctc tcctgagtgg 98521 atcctgagta cggcggaaca cgtgaaattc cgtcggaatc cgggaggacc atctcccaag 98581 gctaaatact ccctagtgac cgatagtgaa ccagtaccgt gagggaaagg tgaaaagcac 98641 cccggaaggg gagtgaaaga gatcctgaaa ccgtgtgcct acaagtagtc agagcccgtt 98701 aacgggtgat ggcgtgcctt ttgtagaatg aaccggcgag ttacgatccc gtgcaaggtt 98761 aagcagaaga tgcggagccg cagcgaaagc gagtctgaat agggcgcatg agtacgtggt 98821 cgtagacccg aaaccaggtg atctacccat gtccagggtg aagttcaggt aacactgaat 98881 ggaggcccga acccacgcac gttgaaaagt gcggggatga ggtgtgggta ggggtgaaat 98941 gccaatcgaa cctggagata gctggttctc tccgaaatag ctttagggct agcctcaagg 99001 taagagtctt ggaggtagag cactgattgg actaggggcc cctaccgggt taccgaattc 99061 agtcaaactc cgaatgccaa tgacttatcc ttgggagtca gactgcgagt gataagatcc 99121 gtagtcgaaa gggaaacagc ccagaccgcc agctaaggtc ccaaagtata cgttaagtgg 99181 aaaaggatgt ggagttgctt agacaaccag gatgttggct tagaagcagc caccatttaa 99241 agagtgcgta atagctcact ggtcgagtga ctctgcgccg aaaatgtacc ggggctaaac 99301 gtatcaccga agctgcggac tgttcttcga acagtggtag gagagcgttc taagggctgt 99361 gaagccagac cggaaggact ggtggagcgc ttagaagtga gaatgccggt atgagtagcg 99421 aaagaggggt gagaatcccc tccaccgaat gcctaaggtt tcctgaggaa ggctcgtccg 99481 ctcagggtta gtcgggacct aagccgaggc cgaaaggcgt aggcgatgga caacaggttg 99541 atattcctgt accacctcct caccatttga gcaatggggg gacgcaggag gatagggtaa 99601 gcgcggtatt ggatatccgc gtccaagcag ttaggctggg aaataggcaa atccgtttcc 99661 cataaggctg agctgtgatg gcgagcgaaa tatagtagcg aagttcctga ttccacactg 99721 ccaagaaaag cctctagcga ggtgagaggt gcccgtaccg caaaccgaca caggtaggcg 99781 aggagagaat cctaaggtga tcgagagaac tctcgttaag gaactcggca aaatgacccc 99841 gtaacttcgg gagaaggggt gctctgttag ggtgcaagcc cgagagagcc gcagtgaata 99901 ggcccaggcg actgtttagc aaaaacacag gtctctgcga agccgtaagg cgaagtatag 99961 gggctgacgc ctgcccggtg ctggaaggtt aagaggagcg cttagcgtaa gcgaaggtgc 100021 gaattgaagc cccagtaaac ggcggccgta actataacgg tcctaaggta gcgaaattcc 100081 ttgtcgggta agttccgacc cgcacgaaag gcgcaacgat ctgggcactg tctcaacgag 100141 agactcggtg aaattatagt acctgtgaag atgcaggtta cccgcgacag gacggaaaga 100201 ccccgtggag ctttactgca gcctgatatt gaatgttggt acagcttgta caggataggt 100261 aggagccttg gaaaccggag cgccagcttt ggtggaggca tcggtgggat actaccctgg 100321 ctgtattgac cttctaaccc gccgccctta tcgggcgggg agacagtgtc aggtgggcag 100381 tttgactggg gcggtcgcct cctaaaaggt aacggaggcg cccaaaggtt ccctcagaat 100441 ggttggaaat cattcgcaga gtgtaaaggc acaagggagc ttgactgcga gacctacaag 100501 tcgagcaggg acgaaagtcg ggcttagtga tccggtggtt ccgcatggaa gggccatcgc 100561 tcaacggata aaagctaccc cggggataac aggcttatct cccccaagag tccacatcga 100621 cggggaggtt tggcacctcg atgtcggctc atcgcatcct ggggctgtag tcggtcccaa 100681 gggttgggct gttcgcccat taaagcggta cgcgagctgg gttcagaacg tcgtgagaca 100741 gttcggtccc tatccgtcgc gggcgcagga aatttgagag gagctgtcct tagtacgaga 100801 ggaccgggat ggacgcaccg ctggtgtacc agttgttctg ccaagggcat cgctgggtag 100861 ctatgtgcgg acgggataag tgctgaaagc atctaagcat gaagcccccc tcaagatgag 100921 atttcccatt ccgcaaggaa gtaagatccc tgaaagatga tcaggttgat aggtctgagg 100981 tggaagtgtg gcgacacatg gagctgacag atactaatcg atcgaggact taaccatatt 101041 tttgaatgat gtcacatctg ttatctagtt ttgagagaac actctcaatt tgtttggtgg 101101 cgatagcgaa gaggtcacac ccgttcccat accgaacacg gaagttaagc tcttcagcgc 101161 cgatggtagt cgggggtttc cccctgtgag agtaggacgc cgccaagcaa gcttaaaccc 101221 agctcaatga gctgggtttt ttgtattttg gtttattggt atcataaaat tccacttaac 101281 tgtataatat aataacttta taccgaattt taaatcagca atcaggtttt gtggaccggg 101341 aaaatggaaa taatgaagga tagagcgaga aagttgaaaa ttctcgagaa acggcttata 101401 gtaagattaa agtcaaatat agtcaaagtc agtaaaggag ggggttgagt gggacataat 101461 atttctgaca tcattgaaca atatttaaaa cgagtgttag atcaaaatgg caaggaaatt 101521 ttagagatta aacgaagtga aattgcagat aaatttcaat gcgttccttc ccaaataaat 101581 tatgtcatca acaccagatt tacaagcgaa agaggatata ttgttgagag caaacgcggg 101641 ggcggcggtt acatcagaat cattaaaatt aaaatgaaca atgaagttgt cctgatcaat 101701 aatataattt ctcaaattaa tacccatttg tctcaagcag cctctgatga cattatttta 101761 aggctattag aagacaaggt aatttcagaa agagaagcaa aaatgatggt cagcgtaatg 101821 gaccgctcag ttttacacat tgacttacct gaacgtgatg aattaagagc gagaatgatg 101881 aaggcaatgc tgacttcttt aaaattaaaa taagcgggtg aaaagattga tttgtcaaga 101941 gtgccacgag agaccagcca cttttcactt tacaaaggtt gttaacggag aaaaaataga 102001 agttcatatt tgtgaacaat gtgccaaaga aaatagtgat tcatatggta taagtgcaaa 102061 tcagggtttc tctattcata atttactttc gggtttactg aacatggatt cttcatttca 102121 aaatgcagga actcaaatgt tcagtcactc ggagcaaata tctgcttgtc cgaaatgcgg 102181 aatgactttt cagcaattca gaaaaattgg ccgttttgga tgttctgaat gttacaaaac 102241 atttcatagc aacattacac caatcctacg taaagtgcac agcggaaaca ctgtgcatgc 102301 aggtaagata ccgaaacgaa taggcggcaa tcttcatgtc agacggcaga ttgatatgct 102361 aaaaaaggaa ttagaatcct taatccatca agaagaattt gaaaatgcag ctcatgtaag 102421 agatcaaatt cgtttattag aacaatcact caaaagtaca gatagtgagg aggaacagga 102481 gtaatgtcgc taaagcattt tattcaggac gcactaagca gttggatgaa gcagaaagga 102541 cctgaaagtg acattgtact cagcagccgc atacgtttag caagaaactt tgagcatatt 102601 cggttcccta cgcggtattc caatgaagaa gcctcatcca tcatacagca atttgaagat 102661 cagttttcag agcaagaaat tcccggaatc ggcaaatttg ttttgattag aatgaatgat 102721 gcacagcctt tagaaaagcg tgtacttgtt gaaaaacatc taatcagccc gaatttgaca 102781 gagtctcctt ttggcggctg tttgctttct gaaaatgagg aagtaagcgt catgctaaat 102841 gaagaggacc atattagaat tcagtgtctt ttccctggat ttcagctttt agaagcaatg 102901 aaagccgcaa accaggtcga cgactggatt gaagaaaaag ttgattatgc attcaatgag 102961 caaagaggat acttaaccag ctgtcctaca aacgtaggta ctggtttaag ggcttcggtc 103021 atgatgcatc tgccggcgct ggttttaact aggcaaataa atcgaattat accggcaatt 103081 aatcaattag gcttagttgt tagaggaatt tatggggaag gcagcgaagc agtagggaat 103141 atctttcaaa tttcaaatca gatcacgctt ggtaagtcag agcaggatat tgtagaggat 103201 cttaacagtg ttgctgctca gttgattgaa caagaacgat ctgcccgaga agcgatttat 103261 caaacttcta aaatcgaact tgaggatcgg gtatatcggt catatggggt cttgtctaat 103321 tgccggatga tagaatcgaa agaaactgca aagtgccttt cagatgttcg gttaggcata 103381 gacttaggca taataaaagg actttcaagc aacatactta acgaacttat gattttgacg 103441 cagccagggt ttttacagca atactcggga ggcgctttgc gaccgaacga aagggacatt 103501 cgaagagcgg ctctcatcag agaacggctt cacttagaaa tgaatgggaa aagacaggag 103561 gatgaatcga tatgatgttt ggaagattta cagaacgagc tcaaaaagta ctggcgctag 103621 cacaggaaga agcacttcgg ttaggtcata ataacattgg cactgagcat attttattag 103681 gactggtaag agaaggagag ggcattgctg ctaaagctct tcaagcgctt ggactcggtt 103741 cagaaaaaat tcagaaagaa gtagaaagtt tgatcgggcg cgggcaggaa atgtctcaaa 103801 cgattcatta tactcctaga gctaaaaaag tcattgagct ttcaatggat gaggcaagaa 103861 aactcggtca ttcttatgtg ggaacagaac atattcttct tggtctgatt cgtgaaggag 103921 aaggtgttgc tgcgagagtt ctgaataatc tcggtgtcag cttaaataaa gcaagacagc 103981 aggtgctcca gcttctagga agtaatgaaa caggatcatc agcggcagga acaaacagca 104041 atgcgaatac gcctacgctt gacagcttgg caagagactt aactgctatt gcgaaggaag 104101 acagccttga ccctgtaatc ggcagaagca aggagatcca gcgtgtcatt gaagtgttaa 104161 gccgcagaac gaaaaacaac cctgttctca ttggggaacc aggtgtaggt aaaacggcta 104221 tcgcagaagg tttggcacag caaattatca ataatgaagt acccgaaatt ttgcgtgata 104281 aacgtgtgat gacattagac atgggaacag ttgttgccgg cacaaaatac cgcggagaat 104341 ttgaggatcg cctgaagaag gtcatggatg aaattcgcca ggcaggaaat atcattctat 104401 tcatcgatga gctccataca ttaatcgggg caggcggagc agaaggtgct attgatgcat 104461 ctaatatttt aaaaccttca cttgctcgtg gcgaactcca atgtattggt gcaacgactc 104521 ttgatgagta ccgtaaatat attgaaaaag atgcagcact ggaacgccgt tttcagccga 104581 ttcaggttga tcagccatct gtagatgaaa gtattcaaat tttacaaggt ctgcgtgaca 104641 gatacgaagc ccaccaccgc gtttctatca ctgatgatgc cattgaagct gcggttaagc 104701 tttctgacag atatatttct gaccgcttcc ttccggataa agcaattgac ttgatcgatg 104761 aagcgggttc aaaggtgaga ctgcgctcat ttacaacgcc tcctaactta aaagagcttg 104821 agcagaagct tgatgaggtt cgtaaagaga aggatgcggc agtgcaaagc caagagtttg 104881 aaaaagctgc ttccttgcgt gatactgaac aacgcctgcg cgagcaagta gaggatacga 104941 agaaatcatg gaaagagaag caagggcagg aaaactcaga ggttactgtg gatgatattg 105001 cgatggttgt atccagctgg accggtgtgc ctgtatctaa aatcgcccaa actgaaactg 105061 ataagcttct caatatggaa aacattcttc actcccgtgt catcggccag gatgaagcag 105121 ttgtagcggt tgcaaaagcc gtcagacgtg caagagcagg attgaaagat cctaaacgcc 105181 caatcggctc attcattttc ttaggcccta caggtgtagg taaaacagaa cttgcacgag 105241 cacttgctga atccattttt ggcgatgaag aatccatgat cagaattgat atgtctgaat 105301 acatggaaaa acattcaact tcaagacttg ttggttcacc tccgggttat gtgggatatg 105361 atgaaggcgg tcaattgaca gagaaagtca gaagaaaacc ttactctgtc gtgcttcttg 105421 atgagatcga gaaagcgcac cctgatgtct tcaatatcct tctgcaagtt cttgaagacg 105481 gacgattgac tgattctaaa ggacgcacag tcgatttccg caataccatt ctgatcatga 105541 catcaaacgt cggagcaagt gagctaaaac gcaataaata tgtcggcttt aacgttcagg 105601 atgaaactca aaatcataaa gacatgaaag ataaagtgat gggtgaatta aaacgagcgt 105661 tcagacctga gttcatcaac cgtattgatg aaatcattgt cttccattca cttgagaaaa 105721 aacatctcac tgagattgtg tcattaatgt ctgatcaatt aacgaaacgc ctgaaagaac 105781 aagatctttc tatcgaattg acagatgctg caaaagcgaa agtcgcggaa gagggcgttg 105841 acctggaata cggtgcccgt ccgttaagaa gagcgatcca aaaacatgtc gaggatcgtt 105901 tatctgaaga actcctcaga ggaaatattc ataaaggaca gcatattgtt cttgatgtag 105961 aagatggcga atttgtcgta aaaacgactg ctaaaacgaa ttaatataga agacggaaat 106021 gaggcataca gcatgtaagt gtatgcctca ctttcatatc aagaaataga acaagggaga 106081 ggtcttacac tatatatggc taaaacaaaa tcgaagttca tctgccaatc ctgcggctac 106141 gagtctccaa aatggatggg gaaatgtccg ggctgtggtg cttggaatac aatggtggaa 106201 gaaatgatta aaaaagcacc ggccaatcgg agagcggctt tttctcattc tgttcaaact 106261 gtacagaaac cttcacctat tacatcaatc gaaacatcag aagaaccccg cgtcaaaacc 106321 cagcttggcg agtttaacag agtactcggc ggaggtgtcg ttaaaggctc cctcgtttta 106381 attggcggtg atcctggtat cggaaagtca acgctattac tgcaggtttc cgctcaatta 106441 tcaggctcat caaacagtgt cctgtatatt tcgggagaag aatctgtaaa gcaaacgaag 106501 ctgcgagcag accgtctcgg cattaataat ccgtcactgc atgttttatc tgaaaccgat 106561 atggagtata tttcgtctgc tatacaagag atgaatccat cgtttgtcgt tgttgactct 106621 attcaaacgg tttaccaaag cgatattaca tctgctccag gcagtgtgtc acaggtcaga 106681 gaatgtaccg ctgagctgat gaaaattgca aaaacaaaag gtattccgat ttttatcgta 106741 gggcacgtga cgaaagaagg gtctattgca ggtccgagac tgttggagca tatggttgac 106801 actgttttat attttgaagg agaacgccac catactttcc gtattttgcg ggctgtaaaa 106861 aaccgtttcg gatctacaaa cgaaatgggc attttcgaaa tgcgggaaga ggggctcact 106921 gaggttttga atccttcgga aattttctta gaagaacgct ctgctggttc cgcaggctcg 106981 agtatcactg cctctatgga gggcactaga ccgattctcg ttgaaattca ggcactcatc 107041 tcgccaacaa gttttggcaa cccaaggcgt atggcaacgg gaatagacca taacagggtt 107101 tctctgttaa tggctgtgtt agaaaaaaga gttggactgc tgctgcaaaa tcaggatgct 107161 tatttgaaag tggctggcgg cgttaagctt gatgaaccgg caattgatct tgcgattgtg 107221 attagtattg catcaagctt tagagacaca cctccaaatc ctgcagattg ttttattgga 107281 gaagtgggat taaccggaga agtccggcgg gtttcaagaa ttgaacagcg tgtgaaagaa 107341 gcggcaaagc ttggttttaa acgcatgatc atacccgcgg caaatctgga tggatggaca 107401 aaaccaaaag ggattgaggt tatcggagta gcaaatgttg cagaagcgct tcgtacttca 107461 ttaggaggat aatagatgga aaaagagaaa aaaggggcga aacacgagtt agacctgtca 107521 tctatattgc agtttgttgc tccgggtaca ccgctcagag cggggatgga aaacgtcttg 107581 agagcaaata caggcggtct gattgttgtt ggatataatg ataaagtaaa agaagtggtg 107641 gacggcggct ttcacataaa cacggctttt tctccggcgc atttatatga gctggctaaa 107701 atggatggag cgatcatttt aagtgattct ggtcaaaaga tcctatacgc gaatactcag 107761 ctgatgccgg atgccacaat ttcttcatca gaaacaggaa tgcggcacag aactgccgaa 107821 agagtagcta agcaaactgg ctgtcttgta atcgccattt ctgaaagaag aaatgtcata 107881 acgttatatc aggaaaacat gaagtataca ctaaaagaca taggatttat tttaaccaag 107941 gcgaaccaag ccattcaaac acttgaaaaa tataagacaa tcctcgataa aacgattaat 108001 gcactgaacg cgttagagtt tgaggaactt gttaccttca gtgatgtctt gtctgtcatg 108061 catcgttatg aaatggtact gagaatcaaa aacgaaatta atatgtatat caaagagctg 108121 gggacagaag ggcatctgat caaactgcaa gtcattgaat tgattacgga tatggaagaa 108181 gaggccgctt tatttattaa ggactatgta aaagaaaaga ttaaagatcc gtttgttctc 108241 ttgaaggagc tgcaggatat gtccagttat gatctgctgg atgattccat tgtgtataag 108301 cttctcggtt accctgcttc tactaatctt gatgattatg tattgccgag aggatacagg 108361 ctgttaaata agataccgcg tcttccgatg ccgattgttg aaaatgttgt agaagcattt 108421 ggagtcctgc caaggattat tgaggcgagt gcagaagaat tagatgaagt agagggaatc 108481 ggtgaagtac gagcccaaaa aatcaaaaaa ggattaaaac gcctgcaaga gaagcattat 108541 ttagacagac aactgtgatt tcggttaaaa ccttatgaat acgggtatat taatgttggt 108601 ttttgtttat tctgatattc gtaggatgca taagactttg tgaaattaaa atgttaaaaa 108661 aggaggtggg ggtatgttaa aacgaatagt tcaggcgttc ttcattattt ttggcggcgt 108721 tgttggtata tttttgatac ctgaattgtt tgtactgtta aatatacagg acataccttt 108781 aataacaaac gcatatacgt ctgcggcaat aggagcaatt atcttttttc tcatcagtat 108841 atggggtaca gaatacgttg tgaactgggt gaagtggata gaggattcat tgttaaaagc 108901 gccggttcca gatttgttat ttggaagtct tggcttagtt tttggactta taattgctta 108961 tcttatcgta aatgttattc ctttagacaa tataccttac cgcatattca gcacaataat 109021 tcctgtattt ttggctttct tcctcggtta tctcggcttc caggtgggct ttaagaaaaa 109081 ggatgaattg atcagcctgt tttccatttc cgccagaatg caaaagaaaa aaggaacagc 109141 tgatgaagaa catgaggttc aagacaagaa gctgaaaatt ttggacacta gtgttattat 109201 tgatgggaga atagcagata tttgtcagac tggtttttta gagggagtta tcgtgattcc 109261 gcagtttgtc cttgaggaat tgcagcatat tgcagactct tcagatgttt taaaacgaaa 109321 cagaggacgc cgcggtcttg atatcctgaa ccgcattcag aaagaattag acattgaagt 109381 tgaaatttac gaaggcgact ttgaagatat tcaggaggtt gacagcaagc tcgtcaaact 109441 tgctaagctg acatccgggg tcgttgtgac gaatgatttt aatttaaata aagtgtgcga 109501 gcttcagaag gtagcagtat taaacattaa tgaccttgcc aatgcggtta agcctgttgt 109561 gcttcctggc gaggaaatga atgttcaggt cattaaggac gggaaagagc ataatcaggg 109621 agttgcctac ttggatgacg gtacgatgat tgtcgttgaa gaaggacgga attatatcgg 109681 caagcatatt gatgtactcg tcacaagtgt gctgcagaca gcagcgggac gaatgatttt 109741 tgcgaagcct aagctgttgg agaaggcgct gtaaagggag aagaaacaat gagttatgat 109801 gtggtgattc ctgcagccgg acagggaaag cggatgaagg cagggagaaa taaactgttc 109861 attgagctga agggagaccc ggtgatcata cacacgttaa gagtgtttga cagccaccgg 109921 cagtgcgata aaatcatttt ggtgattaac gagcaggagc gggagcactt tcagcaattg 109981 ctgtccgatt acccgtttca aacttcaatt gagcttgttg caggcggaga tgagcgacag 110041 cacagtgtgt ataaggggct gaaagccgta aagcaggaaa agattgtcct tgtacatgac 110101 ggtgcccgtc catttataaa acatgaacaa attgacgaac tgatcgcaga ggcggaacag 110161 acaggagcgg ccatccttgc tgttccggta aaagatacga ttaaacgcgt tcaagattta 110221 caagtcagtg agacgattga acgttcaagc ttgtgggctg tccaaacgcc acaagctttt 110281 cgtctttctt tattgatgaa ggctcacgct gaggccgagc gcaagggatt tttagggacg 110341 gatgacgcca gcctcgttga acagatggag ggcggttcgg tccgtgttgt agaaggcagc 110401 tatacaaata ttaagctgac gacgccagac gatttgacgt cagctgaagc tatcatggaa 110461 tcagaaagtg ggaataaaca tgtttagaat tggacaagga tttgatgtgc atcaattagt 110521 ggagggccgt cctctcatta ttggcggaat tgaaatcccg tacgaaaaag ggctgcttgg 110581 ccattctgat gcagacgtat tgttgcatac cgtcgctgac gcctgcctgg gagctgtggg 110641 tgaaggagac ataggcaagc attttcctga cacagatccc gagttcaagg acgcagattc 110701 tttcaaatta cttcagcatg tctggggaat cgtgaaacag aaggggtatg tccttgggaa 110761 cattgattgc accatcatag cgcaaaagcc gaagatgctg ccgtacatag aagatatgag 110821 aaaaagaatt gctgaaggcc ttgaggcaga tgtttctcaa gtaaatgtaa aagcaacaac 110881 gacagaaaag cttggattta caggccgggc ggaaggaata gcggctcagg cgacagtact 110941 gatacaaaaa ggctaacttg ttttgatgcc gggtctattt ggtggtagaa tagattcata 111001 catttttgcc tgaggccata catgacatga aaggaagtat ttgaaaatgg gaaacgaagt 111061 acgcgtccgt tatgcaccga gtccaaccgg acatttgcat attggaaatg ccagaacggc 111121 gctttttaat tatttatttg cccgcaatca aggcggtaag tttatcattc gagttgagga 111181 tactgataaa aagcgcaata ttgagggcgg agaacaaagc cagctgaatt atctgaagtg 111241 gctaggtatt gactgggatg agagtgtgga tgtcggagga gagtacggtc cataccgtca 111301 gtcagagcgt aacgatatct ataaagtgta ctatgaagag cttcttgaaa aagggcttgc 111361 ttataaatgt tactgtacgg aagaagagct tgaaaaagag cgtgaagaac agattgcccg 111421 cggagaaatg cctcgttatt ccggaaaaca cagagacctg actcaggaag aacaggagaa 111481 atttatcgcc gaaggcagaa aaccaagtat tcgtttccgt gtgccggaag gaaaagtcat 111541 cgccttcaac gacatcgtaa aaggcgaaat ttcttttgaa tcagatggca tcggcgactt 111601 cgttattgtg aaaaaggacg gaacgcctac ttataacttc gcggtagcta ttgatgacta 111661 cttaatgaaa atgacacacg tgctgcgcgg tgaggatcat atttctaaca caccgaaaca 111721 gattatgatc tatcaagcat tcgggtggga tattcctcag ttcggacaca tgacgctgat 111781 tgtaaacgaa agccgtaaaa agctcagcaa acgtgatgaa tccattattc aattcatcga 111841 gcagtacaaa gagcttggct acctgccaga agcgctgttc aactttatcg gcttgttagg 111901 ctggtcaccg gttggagaag aagagctttt cacaaaagag cagtttattg aaatttttga 111961 tgtaaatcgt ttatctaaat caccagcttt gtttgatatg cataagctaa aatgggttaa 112021 caaccaatat gtgaagaagc tggatcttga tcaggttgtt gaactgacgc ttccgcattt 112081 gcaaaaagcc ggcaaagttg gcactgagct ttctgctgaa gaacaagaat gggttcgtaa 112141 actgatttcc ctgtatcatg agcaattaag ctacggtgcg gaaattgttg agctgactga 112201 tttgttcttt acggatgaga tcgagtataa tcaagaagcg aaagctgttc tggaagaaga 112261 acaggttcct gaagtgctca gcacattcgc agcgaagctt gaagagcttg aggagttcac 112321 tccggataat atcaaagcat cgatcaaagc agtgcagaaa gaaactggcc ataaagggaa 112381 aaaactgttt atgccgattc gtgttgctgt aacagggcaa actcacggtc cggaactgcc 112441 gcaatcaatt gaattgatcg gtaaagagac tgcaattcag cgtttaaaga atatctaaat 112501 aaatgattgt tgacagggaa gagtataaag ctttaggcca ttacagaaag gatcttcatt 112561 ggctgagaga gatccatgag ccgggtttta gaagtgcgcc cttaagacct ttgaagaacg 112621 ttttttgaaa tcagtattca aaggcggccg ccgccgttac aggctgaagt tgggagagca 112681 gaagtctgct tttcaaacag agtggaaccg cgcggttaaa gcgtctctgt catgtttaca 112741 tgcagagacg ctttttttat tgggtagagg aaatcagata gagaaacggg gggaagcatg 112801 tgttttttag aatgctcaaa gaagacattg atactgtgtt cgatcaagat cccgcagcaa 112861 gaagctattt tgaagtgatt ttaacttatt ccggtttaca tgctatatgg gcgcatcgga 112921 ttgcacatgc tttatataaa cgaaaatttt atttccttgc acgccttata tctcaagtaa 112981 gccgattttt taccgggata gaaatccacc ccggcgctac aatcgggaga agatttttca 113041 tagaccacgg catgggggtt gtcattgggg agacatgtga aatcggcaat aacgtaaccg 113101 tttttcaggg ggttaccctc gggggaacgg gaaaagaaaa gggaaaaagg cacccaacga 113161 ttaaagatga cgcattgata gccacaggtg ctaaagtgct cggttctatt acggtcggtg 113221 aaggctcaaa gattggcgct ggttcagtag tgctgcatga tgttcctgat ttttcaacag 113281 ttgtcggtat ccctggacgg gtcgttgtac aaaatggcaa gaaagtaaga cgcgatttaa 113341 accatcagga tttgcccgat ccagttgctg accgctttaa gtctttggaa cagcagattt 113401 tagagctgaa ggcagaactt gaagacagaa aagaaaggat caatcaaaaa tgacaatcac 113461 actttataat acattgacta gacagaagga aacattcgtt cctcttgaag agggaaaagt 113521 gaaaatgtat gtatgcggac ccacggttta caattacatt catatcggga acgcgcgtcc 113581 ggcaatcgtt tacgatacgg ttcgaaacta tttagagtat aaaggctatg atgtgcagta 113641 tgtctctaac ttcacagacg tagacgataa attaattaaa gcggcaaatg aactcggtga 113701 ggatgtaccc accatttcag agcgttttat taaagcatac tttgaagacg taggtgcgct 113761 cggctgccga aaagccgacc ttcatccgcg agtaatggag aacatggatg ccattatcga 113821 attcgtagat cagctcgtga aaaagggcta cgcatatgaa tcagaaggtg acgtatattt 113881 caaaaccaga gcatttgaag ggtacggaaa gctttctcag caatcaatcg atgaactaag 113941 atcaggtgca cgcatccggg tcggcgagaa aaaagaagat gctcttgatt tcgcactgtg 114001 gaaagcggca aaagaaggag aaatctcttg ggatagccct tgggggaaag ggcgtccggg 114061 ctggcacatt gaatgctcag caatggtgaa aaagtatctc ggtgaccaga ttgatatcca 114121 tgcgggcgga caggatttaa cattccctca ccatgaaaac gaaattgcgc aatctgaggc 114181 gctgacaggc aaaacgtttg cgaagtactg gcttcataat ggttatatca atattgataa 114241 tgaaaaaatg tcaaaatcac taggcaactt tgtgcttgtg catgacatca ttaaacagca 114301 tgatccgcag cttttgagat tctttatgct atctgttcat tatcgccatc cgattaacta 114361 ttcagaagag cttctggaga atacgaaaag cgcgttcagc cgtttaaaaa cagcgtacag 114421 caatcttcag caccgtctga acagcagtac gaatttaacc gaagatgacg atcaatggct 114481 tgaaaaggtt gaagaacacc gcaaagcatt cgaagaagag atggacgatg attttaatac 114541 ggcgaatgcc atttcagtct tgtttgactt agcgaaacac gccaattatt atcttcagaa 114601 agatcatacg gctgatcatg tgattacggc gtttattgag atgtttgacc gcattgtttc 114661 tgtcctcggt ttttcgttgg gtgagcagga acttctcgat caagagattg aagacttaat 114721 cgaaaagcga aatgaagcgc gccggaatcg cgattttgca ttgtcagacc agatccgcga 114781 ccagctgaaa agcatgaata tcattcttga agatacggct caaggcactc gctggaaacg 114841 gggagaataa cagatgcttg aatttgatac gataaaagat tctaagcagc ttaacggtct 114901 tgcgcttgct tatataggtg atgccatttt tgaagtgtat gtcaggcatc acctgcttaa 114961 gcagggcttt accaaaccaa atgatcttca taagaaatca agccggattg tttcagcaaa 115021 gtcacaggct gagatcctat tttttctgca gaatcaatca ttttttacgg aagaagagga 115081 agcggtgctg aaaagaggca gaaatgccaa gtcagggaca acacctaaaa atacagatgt 115141 tcagacgtac cgctacagta cagcatttga agcgcttctg ggctaccttt ttctagagaa 115201 aaaagaggaa cgacttagtc agctcgtagc cgaagctata caattcggga cgtcagggag 115261 gaaaacaaat gagtcagcaa catgattacg tcatagggaa aaatgcagtg atcgagacgt 115321 taaaatctga tcggaagctg tataagctgt ggatggcgga aaacaccgta aagggacaag 115381 cacagcaagt gattgagctt gccaaaaagc agggaatcac gattcaatac gtcccgagaa 115441 aaaaactcga tcaaatggtg acaggacagc atcagggcgt agtggcacag gttgcagcgt 115501 atgaatatgc agaactggac gatttatata aagcagccga agaaaaaaat gaacagcctt 115561 tcttcctcat tctggacgag cttgaagacc ctcataatct tggttccatt atgaggacag 115621 cagatgcggt cggcgctcat ggcatcgtca ttccaaaacg gagagctgtc gggctgacaa 115681 caacagtggc aaaagcttca acaggagcaa ttgagcacat tcctgtagca agagtcacca 115741 atttggcacg gacgttagaa gagatgaaag agcggggaat ctgggttgtc ggaacggatg 115801 cgtccgcgcg tgaggatttc cgtaatatgg acggcaatat gcctttggct ctagtcatcg 115861 gaagtgaagg aaaagggatg ggccgccttg tgaaggaaaa gtgcgatttt ctcattaaac 115921 tcccgatggc cggaaaggta acttcactaa atgcatctgt cgcggctggt cttttgatgt 115981 atgaagtcta ccggaaacga aaccctgtgg gagaataaag acccatggat atcctgttag 116041 tagacgggta caacatgatt ggagcctggc cgcagctgaa ggatttaaaa gcgaacagtt 116101 ttgaagaggc gagagacgta ctgattcaga aaatggcgga atatcaatcg tatacaggaa 116161 acagggttat tgttgttttt gacgcgcatc tcgtaaaagg gcttgagaaa aaacagacca 116221 accatagagt tgaagtaatt tttacaaaag aaaatgagac ggctgatgag cggatagaaa 116281 agctcgctca ggctttgaat aatattgcga ctcaaattca cgttgcgacc tctgactata 116341 ctgagcagtg ggcgattttc ggacaggggg cattgcggaa atcggcccgg gagcttctga 116401 gagaggtaga aacgattgaa aggcgaatag agagacgggt aagaaaaatc acttccgaaa 116461 agccggcggg taaaattgct ttatcggaag aggttttgaa aacgtttgaa aagtggaggc 116521 ggggagactt agattaagtt gacgcttttt tgcccaatac tgtataatat ttctatctac 116581 gtgcgccggg gggatcggag tgaatctaca gaacaacaag ggaaaattca acaaagagca 116641 gttttgccag ttggaggacg agcaggtcat tgaaaaggtt catgttgggg acagtgatgc 116701 gttagattac ttgattacga agtaccgaaa ctttgttcgg gcaaaagcaa gatcctattt 116761 cttaataggg gcggacagag aggatattgt tcaggaaggc atgataggcc tctataagtc 116821 tattcgtgac ttcaaagagg acaagcttac ctcattcaaa gcttttgcag aattatgtat 116881 tacccgccaa attattaccg caataaagac agctactcgc cagaaacaca ttcctttgaa 116941 ttcctacgcc tcattagata aaccgatctt tgatgaagaa tcagaccgaa cgctgctgga 117001 tgtcatttca ggagcgaaaa ccttaaatcc tgaggaaatg atcattaatc aggaagaatt 117061 tgatgatatt gaaatgaaaa tgggagaact attaagtgat ttagagagaa aagtactcgt 117121 cttatatctc gacgggagaa gttaccaaga gatttctgat gaactgaacc gacatgtgaa 117181 atcgatcgac aatgcccttc agcgtgtgaa acgcaagctg gagaagtact tggaaattcg 117241 cgaaatcagt ttgtaatagg aatttatgct atattgacag tatttttctg actatgatat 117301 gttactaaag ataagaacta atgtctattt agaaaaaggt gtaatgacat gagaaaaaag 117361 attacgttag catgcaagac atgcggaaac cgtaattata cgacaatgaa gagctctgca 117421 tcagcggctg agcgattaga agtaaagaaa tactgcagta cttgcaattc acatacagct 117481 catcttgaaa caaaatagtt tttgcgcttt taaattgtgg aggtctttta catgcgtatt 117541 atgaaattct ttaaagatgt tgggaaagaa atgaaaaagg taagctggcc taaaggaaaa 117601 gagttaacgc gttataccat tacggtaatt tcaacagtta tcttttttgt tatctttttt 117661 gccctccttg acacaggaat ttctcaatta attcgtttaa tagttgaata atgatcagca 117721 atacgtgcta taatagatca taatattact tgccaaaacc cgttcagcgg gttttttatt 117781 gtggcttaaa atgaaagtta tcataggctt gccgcctatt ttttgaagcg ttatggtaat 117841 tcactaaaac caaatgcggg gagggaagga ctggacagtc ctgaatagaa tggaaaagaa 117901 ttggtatgtt gttcacacgt actctggtta tgagaataaa gtaaaagcca acttggaaaa 117961 gcgtgttgaa tcaatgggga tgcaggataa aattttccgt gtagtcgtac ccgaagaaga 118021 agaaacggat atcaaaaacg gcaagaaaaa agtcgtgaaa aagaaagtat tccctggtta 118081 tgtgcttgtt gaaattgtaa tgacagacga ctcttggtat gtcgtccgca acacgccggg 118141 cgttactgga ttcgtaggat ctgccgggtc aggttcaaaa ccgacgccgc ttcttccggg 118201 ggaagcagaa accattctga agagaatggg catggatgaa cgaaaaactg atattgactt 118261 tgaactgaaa gagacagtga aagtaataga cggacctttt gctaacttta caggatcaat 118321 tgaagagatt gattatgata aaagcaaggt caaagttttc gttaatatgt ttggccgtga 118381 aacgccggtt gagctggaat ttacccaaat cgataaattg taatgtgaaa aaacttgaaa 118441 ttgctatata taaatgataa tatagcaaag gtacgtcttg gacttatcca aggcaactag 118501 catgatattt cgtcattcat ataaagaatg aaaccttgag tgggagggtt taccctatta 118561 ccacatcacg gacttaagga ggtgtgtctc gtggctaaaa aagtagttaa agttgtaaaa 118621 ttgcaaattc ctgctggaaa agctaaccca gcaccaccag ttggacctgc acttggtcaa 118681 gccggtgtta acatcatggg attctgtaag gagtttaacg ctcgtacagc tgaccaagct 118741 ggtttaatca ttcctgttga aatttcggtt tacgaagacc gttcatttac atttattaca 118801 aaaactccac ctgctgcagt attgcttaaa aaagcagctg gaattgagtc tggttctggt 118861 gaaccaaacc gtaataaagt ggcaaccgtt aagcgcgata aagtacgcga aatcgctgaa 118921 acgaaaatgc ctgacttaaa cgcagcagac gttgaagcgg caatgcgcat ggttgaaggt 118981 actgcccgca gtatgggtat tgtaatcgag gattaatttg tttcttgtcg ggttgcgagt 119041 tttaacaagt tcgcaaccct tattcgtggg aggttattcc gctataacca cataaggagg 119101 aaattttaaa atggctaaaa aaggtaaaaa gtacgttgaa gctgctaagc ttgtagaccg 119161 ttctaaagct tacgacgtct ctgaagcagt agctctcgtt aaaaaaacaa acacagctaa 119221 attcgacgct acagttgaag tggctttccg tttaggggtt gaccctcgta aaaacgacca 119281 gcaaatccgt ggagcagttg tgcttccaaa cggaactggt aaaactcagc gcgttctcgt 119341 tttcgcaaaa ggcgaaaaag cgaaagaagc tgaagctgct ggtgcagatt tcgtaggcga 119401 tactgactac atcaacaaaa ttcaacaagg ctggttcgat ttcgatgtta tcgtagctac 119461 acctgacatg atgggtgaag ttggtaaaat cggtcgtgta cttggaccaa aaggtttaat 119521 gccgaaccct aaaactggta cagttacttt cgaagttgaa aaagctatcg gcgaaatcaa 119581 agctggtaaa gttgaatacc gcgttgataa agctggaaac attcatgttc ctatcggtaa 119641 agtttctttc gaggatgaaa aacttgttga gaacttcaca acaatgtacg atacaatcct 119701 taaagctaaa cctgctgcag ctaaaggcgt ttacgtgaaa aacgttgctg taacttctac 119761 tatgggacct ggtgtcaaag tagactcttc aacttttaac gtaaaataat attgacatga 119821 catcaacatt ctgatattat tcaaaatgtt gtaaaataga atatcattta taccgtagac 119881 agtaggggcc taaccgctta attatcctac cgaggtgtat attatcacag ctattacgtt 119941 acgtatgctt gtatatacag cctccatgtc tcatggaggc tttttatatg gaatccgtcg 120001 tctcagtcgt gatcacctaa cggtataagt gttacacaag aatctacagg aggtgtaacc 120061 atgagcagcg caattgaaac aaaaaaagtt gttgttgaag aaattgcttc taaactgaaa 120121 gaaagtaaat caacgatcat cgttgactat cgcggactta acgtttctga agtaactgaa 120181 cttcgtaaac agcttcgcga agctaacgtt gagttcaaag tttacaaaaa tacgatgact 120241 cgccgtgcgg ttgaacaagc tgagcttaat ggtttgaatg atttcttaac tggaccgaac 120301 gcgatcgcat tcagcactga agatgttgtc gctccggcta aagttcttaa tgacttcgct 120361 aaaaatcacg aagctcttga aatcaaagct ggcgttatcg aaggtaaagt ttctactgtt 120421 gaagaagtga aagctcttgc tgaacttcca tcacgcgaag gcttgctttc tatgttgctt 120481 agcgtacttc aagctccagt tcgcaacctt gctcttgctg caaaagctgt ggcagaacaa 120541 aaggaagaac aaggcgctta atctaatcag tttttcataa attaaaacaa aatggaggaa 120601 ttacaaatgg ctttaaatat cgaagaaatc attgcttccg ttaaagaagc aactgtactt 120661 gaattgaacg acctagtaaa agcaatcgaa gaagaatttg gcgtaactgc tgctgctcct 120721 gtagctgtag ctggcggagc tgctgctggc ggagctgctg aagagcaaag cgaattcgat 120781 cttatccttg ctggtgcagg atctcaaaaa atcaaagtta tcaaagttgt acgtgaaatc 120841 actggtcttg gcttgaaaga agctaaagag cttgttgaca acactccaaa accacttaaa 120901 gaaggtattg ctaaagaaga agctgaagag cttaaagcta aacttgaaga agttggcgct 120961 tctgtagaag ttaagtaatc ttcacttacc tgtaggggaa gctcgctttt atgaggcgag 121021 ctttttcttt gccattcttt aagccatgaa aaaaggaggt tctaataatg agtgagcact 121081 attattcaga aaaaccttca gtaaaaagca acaagcaaac ctggtctttt aggcttcgga 121141 ataaagattt cacgtttacc agcgacagcg gggttttttc taaaaaagaa gttgatttcg 121201 gctcccgcct gctgattgat tcttttgaag agcctgaggt tgagggcggc attttagatg 121261 taggctgcgg atacggcccg attggtttat cgctcgccag cgactttaaa gaccggacca 121321 tccacatgat tgacgttaat gagagagccg tagaactatc aaatgaaaat gcggaacaga 121381 acggaataac aaacgttaag atttatcaaa gcgatttgtt ttcaaacgtt gattctgctc 121441 aaacatttgc ttctattctt acaaatcccc caatccgagc cggaaaaaaa gttgtccatg 121501 ctatctttga gaaaagcgct gaacacttaa aagcttcagg tgaattgtgg atcgtcatac 121561 agaaaaagca aggcgcgcct tctgccattg aaaagctcga ggaactgttc gatgaagttt 121621 ccgtcgttca aaaaaagaaa ggctattata tcataaaagc aaaaaaagtt tgactcggta 121681 ttttaactat gttaatattg taaaatgcca atgtatatat tttgcttgat atgatgaatt 121741 gtcaatatct atgtataaat tatacaagta tggaaatgct aataaaatcg gtatttgttt 121801 ttggatgtgg ttttcttaat tagaaaccct tttttctttt gtcttgtaaa agtattttct 121861 ttctttggaa gaaatgctta ttacacatat aatacgcatg atttgagggg tgaatcagtt 121921 gacaggtcaa ctagttcagt atggacgaca ccgccagcgc agaagctatg ctcgcattag 121981 cgaagtgtta gaattaccaa atctcattga aattcaaacc tcttcttatc agtggtttct 122041 tgatgagggt cttagagaga tgtttcaaga catatcacca attgaggatt tcactggtaa 122101 cctctctctt gagttcattg attatagttt aggtgagcct aaatatcctg tagaggaatc 122161 aaaagaacgt gatgtgactt actcagctcc gctaagagtg aaggttcgtt taattaacaa 122221 agaaactgga gaggtaaaag accaagatgt cttcatgggt gatttcccta ttatgacaga 122281 tacaggtact tttatcatta acggtgcgga acgtgttatc gtttcccagc ttgttcggtc 122341 tccaagtgta tatttcagtg gtaaagtaga caaaaacggt aaaaaaggtt ttaccgcaac 122401 tgtcattcca aaccgtggcg catggttaga atacgaaact gatgcgaaag atgttgttta 122461 tgtccgcatt gatcgcacac gtaagttgcc ggttacggtt cttttgcgtg ctctcggctt 122521 cggctccgat caagagattc ttgatctcat aggagaaaac gaatacctgc gaaatacgct 122581 tgataaagat aacacagaaa acagcgacaa agcgttgctg gaaatttacg agcgtctccg 122641 tcctggagag ccgcctacag tagaaaatgc gaaaagcttg cttgattctc gtttctttga 122701 tccgaaacga tacgatcttg ccaatgtagg acgctataaa attaataaaa aacttcatat 122761 taagaatcgc ctcttcaatc agagacttgc tgaaacgctt gttgatcctg aaacaggaga 122821 aatccttgct gaaaaaggcc agattcttga tagaagaacg cttgataaag tactgccata 122881 cttagaaaac ggaatcggtt ttagaaagct gtatccgaat ggcggcgttg ttgaagatga 122941 agtgactctt caatcaatta aaatctttgc tccgactgat caagaaggag aacaggttat 123001 caatgtaatc ggcaatgctt acatcgaaga agagattaaa aacatcacgc ctgctgatat 123061 tatttcttca atcagctact tcttcaacct gctgcacgga gtaggcgaca cagatgatat 123121 cgatcatctt ggaaaccgcc gtttacgttc tgtaggcgag cttctccaga accaattccg 123181 tatcggttta agccgtatgg agcgtgtggt tcgtgagaga atgtcaattc aagatacgaa 123241 tacaattacg cctcagcagc tgatcaatat tcgtcctgtt attgcgtcca ttaaagagtt 123301 ctttggaagc tcacagcttt ctcaattcat ggatcagacg aacccgcttg ctgaattaac 123361 gcacaagcgt cgtctgtcag cattaggacc gggcggattg acacgtgagc gtgccggaat 123421 ggaagtgcgt gacgttcact actcccacta tggccgtatg tgtccgattg aaacgcctga 123481 gggcccgaac atcggtttga tcaactcact atcatcttat gcaaaagtaa accgttttgg 123541 ctttattgaa acgccatatc gccgcgttga ccctgaaaca gggaaggtaa cgggcagaat 123601 cgattactta actgctgatg aagaggataa ctatgttgtc gctcaagcga atgctcgtct 123661 tgatgacgaa ggcgccttta ttgatgacag catcgtagct cgtttccgcg gggagaacac 123721 cgttgtttcc agaaatcgtg tagactacat ggatgtatcg cctaagcagg ttgtatctgc 123781 tgcgacagca tgtatcccgt tcttagaaaa cgatgactcc aaccgtgccc tcatgggagc 123841 gaacatgcag cgtcaggctg tgcctttgat gcagccggaa gcgccatttg ttggaactgg 123901 tatggaatac gtatcaggaa aagactctgg tgccgctgtt atttgtaaac accctggtat 123961 cgttgaacgc gtagaagcca aaaacgtttg ggttcgccgt tatgaagaag tagacggtca 124021 aaaagtaaaa ggaaacctgg ataaatacag cctgctgaaa tttgtccgct ctaaccaagg 124081 tacgtgctac aaccagcgtc cgatcgtaag tgtcggcgat gaagtggtaa aaggagaaat 124141 ccttgctgac ggtccttcta tggagcttgg tgaacttgca cttggccgta acgtaatggt 124201 cggcttcatg acgtgggatg gctacaacta tgaggatgcc atcatcatga gtgaacgcct 124261 agtgaaggat gatgtttata catctatcca cattgaagaa tacgaatcag aagcacgtga 124321 tacgaaactt ggacctgaag aaatcactcg cgatattcca aacgtcggtg aagatgcgct 124381 tcgcaatctt gatgaccgcg gaatcatccg tattggggca gaagtaaaag acggagatct 124441 tcttgttggt aaagtaacgc ctaaaggcgt aactgaactg actgccgaag aacgccttct 124501 tcacgccatc tttggcgaga aagcccgcga ggttcgtgat acttctcttc gtgtgcctca 124561 tggcggcggc ggaattatcc atgacgttaa agtcttcaac cgtgaagacg gagacgaact 124621 tcctccaggt gttaaccagt tagtacgcgt atatatcgtt cagaaacgta agatttctga 124681 aggggataaa atggccggtc gtcacggtaa caaaggtgtt atctctaaga ttcttcctga 124741 agaggatatg ccttaccttc ctgacggcac accaattgat atcatgctta acccgctggg 124801 cgtaccatca cgtatgaaca tcgggcaggt attggaactt cacatgggta tggccgctcg 124861 ttaccttggc attcacattg catctcctgt atttgacgga gcgcgagaag aggatgtctg 124921 ggaaacactt gaagaagccg gcatgtctcg tgacgccaaa acagtgcttt acgacggacg 124981 tactggagag ccgtttgata accgtgtatc tgtcggtatc atgtacatga tcaaactggc 125041 tcacatggtt gacgataaac ttcatgcacg ctctacaggc ccttactcac ttgttacgca 125101 gcagcctctt ggcggtaaag cgcaatttgg cggacagcgt tttggtgaga tggaggtttg 125161 ggcacttgaa gcttacggtg cggcttacac tcttcaagaa attctgactg ttaagtctga 125221 tgacgtggtt ggacgtgtga aaacatacga agccatcgtt aaaggcgaca atgttcctga 125281 accaggtgtt ccggaatcat tcaaagtatt aatcaaagaa cttcaaagct taggtatgga 125341 tgtcaaaatc ctttctggtg atgaagaaga aatagaaatg agagatttag aagacgaaga 125401 agatgcgaaa caagctgacg gcctggcatt atcaggtgat gaagagccgg aagaaacagc 125461 atctgcagac gttgaacgcg atgtagtaac aaaagaataa tctctagtta taaaggcaag 125521 tgacatcggt taatccgaag ataaaaaggg aggtaggccc cttgctagat gtgaacaatt 125581 ttgagtatat gaacatcggt cttgcttcac cagataaaat ccgttcatgg tcttttggtg 125641 aagtgaaaaa gcctgaaacg ataaactatc gtacgttaaa acctgaaaag gacggtctat 125701 tctgcgaacg cattttcgga ccgactaagg actgggaatg tcattgcggg aagtacaagc 125761 gagttcgtta taaaggcgta gtttgtgacc gctgcggagt cgaagtaaca cgggctaaag 125821 tccgtcgtga gagaatgggg cacattgaac tggctgcccc agtttcccac atttggtatt 125881 tcaaaggtat tccaagccgt atgggtcttg tgctggatat gtcacctcgt gctttagaag 125941 aagtcattta ctttgcttct tacgttgtaa ctgatccggc gaatacaccg cttgaaaaga 126001 aacagcttct gtctgagaaa gaataccgtg cttatcttga taaatacggt aataaattcc 126061 aagcatctat gggtgctgaa gcaattcata aacttcttca agatatcgat cttgtaaaag 126121 aagttgatat gttaaaagaa gagctgaaaa cttcacaagg acaacgccgt actcgtgcga 126181 tcaaacgtct tgaagtttta gaagccttcc gtaactcagg aaacaagcct tcttggatga 126241 tccttgatgt gcttcctgtt attcctccgg agcttagacc gatggttcag ctagatggcg 126301 gacgttttgc gacttctgat ttgaatgacc tttatcgtcg tgtcatcaac cgtaacaatc 126361 gtttgaaacg ccttttggac cttggtgcgc ctagcatcat cgttcaaaac gaaaagcgta 126421 tgcttcaaga ggctgtcgat gccctaattg acaacggccg ccgcggacgc cctgtaacag 126481 gtcctggaaa cagaccgtta aaatctcttt ctcacatgct gaaagggaag caaggccgtt 126541 tccgtcaaaa ccttcttggt aaacgtgtcg attactccgg acgttctgta atcgttgttg 126601 gtcctcattt gaaaatgtac caatgcggat taccgaagga aatggcactt gaacttttca 126661 aacctttcgt tatgaaagaa cttgttgaaa aaggtcttgc tcacaacatt aagagtgcga 126721 aacgcaaaat tgagcgcgta cagcctgaag tttgggatgt actagaatca gttattaagg 126781 agcatccggt actgctgaac cgtgccccta cacttcacag attaggtatc caggcgtttg 126841 aaccaacgct tgttgaagga cgcgcaatcc gtcttcaccc gctcgtatgt acagcttaca 126901 acgctgactt tgacggtgac caaatggcgg ttcacgtacc attatctgct gaagcacaag 126961 ctgaagcacg catcttgatg cttgctgctc aaaacatctt gaaccctaaa gatggtaaac 127021 cggttgtaac accgtctcag gatatggtac taggtaacta ttacctgaca cttgagcgtg 127081 ccggtgctgt cggtgaaggt atggtcttca agaatacaga cgaagcgctt cttgcttatc 127141 aaaacggata tgttcacctt catacgagag tagctgttgc agctaactca cttaagaatg 127201 tgacatttac cgaagaacag cgctcaaaat tgttaattac aactgtcggt aagcttgtct 127261 tcaatgaaat tcttccggaa tcattccctt acatgaatga accaacgaag agcaacattg 127321 aagagaaaac acctgaccgt ttcttcttag aaaaaggtgc tgatgttaaa gctgttatcg 127381 cacagcagcc aatcaatgcg ccgtttaaaa aaggcattct gggtaaaatc atcgcggaaa 127441 tctttaaacg attccatatt acggaaacgt ctaaaatgct tgaccgcatg aaaaacctag 127501 gtttcaaata ttcaactaaa gctggtatta cagttggggt ttctgacatc gtcgtactcg 127561 atgataaaca agaaattctt gaggaagcgc aaagcaaagt tgacaacgtt atgaagcaat 127621 tccgccgcgg tcttatcact gaagaagaac gctatgagag agtcatctct atctggagtg 127681 ctgcaaaaga cgttatccaa ggcaaactga tgaaatcact tgatgaactc aacccgatct 127741 acatgatgag tgactctggt gcccgtggta acgcatctaa ctttacgcag cttgccggaa 127801 tgcgcggcct gatggccaac ccggctggac gtatcattga gttgccgatc aaatcaagtt 127861 tccgtgaagg tctgacagta ttggagtact ttatctccac acacggtgcg cgtaaaggtc 127921 ttgccgatac cgctcttaaa actgctgact caggttacct tacacgccgt ctcgttgacg 127981 ttgctcagga tgttatcatc cgtgaaactg attgcggaac tgaccgaggc attcttgcta 128041 agcctcttaa agaaggaact gaaacaattg agcgcttaga agaacgctta atcggacgtt 128101 ttgcaagaaa acaagtgaag caccctgaaa caggtgaagt gcttgtgaat gaaaacgaac 128161 tgatcgatga agataaagca ctggagattg tcgaagccgg cattgaagaa gtgtggatcc 128221 gttctgcctt cacatgtaat acgcctcatg gtgtatgtaa acgatgctat ggccgaaatc 128281 ttgcaactgg ctccgatgtt gaagtcggtg aagctgtcgg aatcattgct gcccaatcaa 128341 tcggtgagcc tggtacacag ttaacaatgc gtacattcca tacaggcggg gttgccggag 128401 acgatatcac acagggtctt ccgcgtatcc aagagctttt cgaagcgcgt aatccgaaag 128461 gtcaggcaac aattacagaa atcgacggta cagtcgttga gatcaatgaa gttcgtgata 128521 agcaacagga aattgtggtt caaggcgcag tggaaacacg ttcttatacg gcaccttaca 128581 actcccgcct gaaagtagcg gaaggagata aaattactcg aggccaagta ctgacagaag 128641 gttcaatcga tccgaaagaa cttcttaaag tgactgacct gacgactgtt caagagtatc 128701 ttctccatga ggttcaaaag gtttaccgta tgcagggtgt tgaaatcggt gataaacacg 128761 tagaagtaat ggttcgccag atgcttcgca aagtacgcgt gattgatgcc ggtgacactg 128821 atgtgcttcc aggtacattg cttgatattc accaatttac tgaagcgaac aaaaaggtat 128881 tgcttgaagg caaccgacca gctacaggcc gtcctgtctt actcggtatt acaaaagcat 128941 ctcttgaaac tgattcattc ttatctgctg cttccttcca ggaaacaaca cgtgtcctta 129001 cagatgcagc gatcaaaggt aagcgtgacg agcttctcgg cttgaaagag aatgttatca 129061 tcggtaagct tgttccagca ggtacaggaa tgatgaaata ccgtaaagta aaaccagtat 129121 caaatgttca gccgactgac gatatggtcc cggttgaata actgatttaa ctctgctgaa 129181 agactgcaaa aacagtcttt cagcagatat atttatgaaa aagtcactct atgagaagaa 129241 cgaatctaaa aaatgtcata ccttgttgac attcgtctcc tagaatgata atataaccaa 129301 ggtgctcgaa ataaacctgt tactttggag gatatgttta tgtcttatga taaagtatca 129361 caggccaaat caattattat tggtacgaag caaacagtga aagctctaaa gcgaggttca 129421 gtaaaggaag tagtcgttgc aaaagacgca gatccgatac tcacgtcaag tgttgtttca 129481 cttgctgaag atcaaggtat ctctgtctca atggttgaat ccatgaaaaa gctcggcaaa 129541 gcctgcggaa ttgaggtagg agcagccgct gttgccatta ttttataacg tacttttgtt 129601 tttgcgtaag attccatctt gtgtaaagac attgtttttt gccttttgat gaaccacctg 129661 ggtatgtggg ttataaaacg taatgaaggg aggaaaaatt catgcctaca attaatcagc 129721 taattcgcaa aggacgcgtg agtaaagtag aaaactcaaa gtctcctgca cttaacaaag 129781 gatacaacag ctttaaaaaa gagcacacta acgtatcttc tccacaaaaa cgcggggtat 129841 gtactcgtgt tggtacaatg acaccgaaaa aaccgaactc agcacttcgt aaatatgctc 129901 gtgttcgttt gactaacgga atcgaggtta ctgcttacat tcctggtatc ggtcacaacc 129961 tgcaagagca cagtgttgta cttatccgcg gcggacgtgt aaaagactta ccaggggtac 130021 gttaccacat cgttcgtggt gcgcttgata ctgctggagt tgaaaaccgt gcacaaggcc 130081 gttctaaata cggtacgaaa aaacctaaag caaaataata tacgaaaata cgcataattg 130141 atgaagggag gatattcaga tgccacgtaa aggtcctgta gcaaaaagag atgttttacc 130201 tgatccgatt tacaactcta agcttgtatc tcgtttaatc aacaaaatga tgatcgatgg 130261 taaaaaaggt aagtctcaaa cgatcctata caagtcattc gatatcatta aagaacgtac 130321 tggcaatgat gcaatggagg ttttcgaaca agcattgaaa aacatcatgc ctgtacttga 130381 agtaaaagca cgccgtgtag gtggtgcgaa ctaccaagtt cctgtagaag ttcgtcctga 130441 acgtcgtacg actcttggac ttcgctggtt agttaactac gctcgtcttc gtggagaaaa 130501 aacgatggaa gagcgtttag ctaacgaaat ccttgacgca gctaacaaca ctggtgctgc 130561 tgttaagaaa cgtgaagaca ctcataagat ggctgaagca aacaaagcat ttgctcacta 130621 tcgctggtag gatttataga ttaacaaaac acaatttcct aataaggaag gagaaattac 130681 ccaatggcaa gagagttctc cttagaaaaa actcgtaata tcggtatcat ggctcacatc 130741 gatgccggta aaacgactac tacagaacgt atcttgttct atactggtcg tatccacaaa 130801 attggtgaaa ctcatgaagg agcttcacaa atggactgga tggagcagga acaagaacgt 130861 ggtatcacaa tcacttccgc tgcgactact gcacagtgga aaggataccg cgtaaacatc 130921 atcgatactc caggacacgt agacttcaca gttgaagttg aacgttctct tcgtgtactt 130981 gatggtgctg ttgctgtact tgacgcgcaa tcaggcgttg agcctcaaac agaaactgtt 131041 tggcgtcagg caacaactta tggagtaccg cgtatcgttt ttgttaacaa aatggacaaa 131101 atcggtgcag acttccttta ctctgtagga actttaagag accgtcttca agcaaacgct 131161 catgcaattc aattgccgat cggtgctgaa gataacttcg aaggtatcat tgaccttgta 131221 gaaaacgttg cgtatttcta cgaagatgac ctcggaactc gttctgatgc aaaagaaatc 131281 cctgaagagt acaaagagca agctgaagag cttcgcaaca gccttattga agctgtatgt 131341 gagcttgatg aagagcttat ggataagtac cttgagggtg aagaaatcac aattgacgag 131401 ttaaaagcag gaattcgtaa aggtacatta aatgttgaat tctaccctgt tcttgttggt 131461 tctgccttca aaaacaaagg tgttcaacta gtacttgatg ctgttcttga ctaccttcct 131521 gcaccaactg acgttgctgc aatcaaaggt acacgtcctg atacaaatga agagattgag 131581 cgtcattctt ctgacgaaga gccattctct gcattagcat ttaaagttat gactgaccct 131641 tacgttggta agttgacgtt cttccgtgtg tactctggaa cacttgattc tggttcatac 131701 gtgaaaaact ctactaaagg caaacgtgag cgtgttggac gtattcttca aatgcacgct 131761 aacagccgtg aagaaatctc tactgtatac gcaggggata tcgcagctgc tgtaggtcta 131821 aaagatacaa ctactggaga tactctatgt gatgagaagg atcttgttat ccttgagtca 131881 atggaattcc cagaaccagt tatcgacgtt gctattgagc ctaaatcaaa agctgaccaa 131941 gataaaatgg gtatcgcttt agcgaaactt gctgaagaag atcctacatt ccgtactcaa 132001 acaaacccag aaactggcca aacgatcatc tctggtatgg gtgaacttca ccttgatatc 132061 attgttgacc gtatgaaacg cgaatttaaa gtagaagcca atgttggtgc tcctcaagtt 132121 gcgtaccgtg aaacattccg taccggtgca aaagttgaag gtaaattcgt acgtcagtct 132181 ggtggacgcg gtcagttcgg acacgtttgg atcgaattcg aaccaaacga agaaggcgct 132241 ggctttgaat ttgaaaatgc gattgtcggt ggggtcgttc ctcgtgaata catcccagct 132301 gttcaagcag gtctggaaga tgcactcgaa aatggtgtac tagcaggctt cccgcttatc 132361 gacattaaag ctaaactttt cgacggttct taccatgatg ttgactcaaa cgaaatggca 132421 tttaaagtcg ctgcttctat ggcattgaaa aatgcagtca gcaaatgtaa cccagttctt 132481 cttgaaccaa tcatgaaagt ggaagtggtt attccagaag aatatatggg agatatcatg 132541 ggtgatatca cttcacgtcg cggacgcgta gaaggtatgg aagcacgcgg taacgctcaa 132601 gttgttcgtg ctatggttcc tcttgctgaa atgttcggtt acgctactgc acttcgttct 132661 aatacgcaag gtcgcggtac gttcactatg cacatggatc actacgaaga agtgccgaag 132721 agcgtcgcag aagaaattat caaaaaaaat aaaggcgaat aattgatttt gccgcttaac 132781 tcaagtataa ctactattgt aagatgagga agtgaaagct ttctttcact tcctatcact 132841 ctatacatta ctaattaaaa gctcttaagg aggattttag aatggctaaa gaaaaattcg 132901 accgttccaa atcacatgcc aatattggta caattggaca cgttgaccat ggtaaaacaa 132961 ctttaactgc tgctatcaca acagtacttc ataagaaatc tggtaaaggt acagctatgg 133021 cgtacgatca aattgatggt gctccagaag aacgcgagcg cggtatcaca atctctactg 133081 cacacgttga gtacgaaact gaaactcgtc actatgcaca cgttgactgc ccaggacacg 133141 ctgactatgt taaaaacatg atcactggtg ctgcgcaaat ggacggagct atccttgtag 133201 tatctgctgc tgatggccca atgccacaaa ctcgtgagca catccttctt tctaaaaacg 133261 ttggtgtacc atacatcgtt gtattcttaa acaaatgcga catggtagac gacgaagagc 133321 ttcttgaact agttgaaatg gaagttcgcg atcttcttag cgaatacgac ttccctggtg 133381 atgatgtacc agttgttaaa ggttctgctc ttaaagctct tgaaggagac gctgagtggg 133441 aagctaaaat cttcgaactt atggatgcgg ttgatgagta catcccaact ccagaacgcg 133501 acactgaaaa accattcatg atgccagttg aggacgtatt ctcaatcact ggtcgtggta 133561 cagttgctac tggccgtgta gaacgcggac aagttaaagt cggtgacgaa gttgaaatca 133621 tcggtcttca agaagagaac aagaaaacaa ctgttacagg tgttgaaatg ttccgtaagc 133681 ttcttgatta cgctgaagct ggtgacaaca ttggtgccct tcttcgcggt gtatctcgtg 133741 aagaaatcca acgtggtcaa gtacttgcta aaccaggtac aatcactcca cacagcaaat 133801 tcaaagctga agtttacgtt ctttctaaag aagagggtgg acgtcatact ccattcttct 133861 ctaactaccg tcctcagttc tacttccgta caactgacgt aactggtatc atccatcttc 133921 cagaaggcgt agaaatggtt atgcctggag ataacactga aatgaacgtt gaacttattt 133981 ctacaatcgc tatcgaagaa ggaactcgtt tctctattcg tgaaggcgga cgtactgttg 134041 gttcaggcgt tgtttctaca atcactgagt aatagtatgg ttttaaacga gacccctgtg 134101 ggtctcgttt tttgtttgct tatctttttc ttgtataata ggatctatca tattcgaggg 134161 gttaatattt atgattcctg aaaagaaatc aatcgcaatc atgaaagaac taagcattgg 134221 aaatacaaag caaatgctga tgattaatgg agttgacgtg aaaaatccat tgctgctttt 134281 tttacatggc gggccgggaa cgccgcaaat cggatatgtt agacattatc aaaaagagct 134341 ggaacagtat tttacagtag ttcattggga tcagagagga tcggggcttt cttattctaa 134401 gcgaatttcg catcactcta tgacaataaa tcacttcatt aaagatacaa tccaagtcac 134461 tcaatggctt ttagctcatt tttcaaaatc aaaactttac ctagccggtc attcttgggg 134521 atcaatactg gcgcttcatg tgctgcagca gcgtcctgat ttattttaca cgtattatgg 134581 aatcagccag gttgttaacc cgcaagatga agaatcaact gcttatcaac atattcgtga 134641 aatttccgaa tcaaaaaaag ccagcatatt atctttcctt acacgtttca ttggtgctcc 134701 gccttggaag caggatatcc agcaccttat ctatcggttt tgtgttgagc taaccagggg 134761 aggattcact caccgtcatc gtcaatctct cgctgtatta tttcaaatgc ttactggcaa 134821 tgagtatgga gtgcggaaca tgcacagctt ccttaatgga ttgcgcttca gtaaaaaaca 134881 tttaactgat gagttgtacc ggtttaatgc ttttacatca gttccttcta ttaaagtacc 134941 gtgtgttttc atttcaggga aacatgactt aattgttcct gcagaaatat cgaaacagta 135001 ttatcaagaa cttgaggcac ctgaaaagcg ctggtttcaa tttgagaatt cagctcacac 135061 cccgcatatt gaggagccat cattattcgc gaacacatta agtcggcatg cacgacacca 135121 tttatgatag atccttgata aataagaaaa acccctgtat aataaaaaaa gtgtgcaaat 135181 catgcatatt ttaaataagt cttgcaacat gcgcctattt tctgtataat ggtgtatgtt 135241 ggtctttgac tgcgatgaag tgagaggttg ctgacacacc cggccgcttt gccatggcaa 135301 ggtgttcagg tttttctcac ggagaactgt ctaacgtgat gtaggcgaaa aggagggaaa 135361 ataatggcaa aacaaaaaat tcgtattcgt ttgaaagcat atgatcatag aatccttgat 135421 caatctgcag agaagattgt tgaaacggca aaacgttctg gtgccagcgt atctggtccg 135481 attccgttgc caactgaaaa atcagtttac acaatccttc gtgcggtgca caaatacaaa 135541 gattctcgtg agcaatttga aatgcgtaca cataaacgtt taatcgacat tgtgaaccca 135601 acaccacaaa ctgttgatgc tcttatgcga ttagacttac catctggtgt cgatatcgaa 135661 attaaacttt aattctaaaa tatagaatga tcttaatagg aggtgtgacg aatgaccaaa 135721 ggaatcttag gaagaaaaat tggtatgacg caagtattcg ctgagaatgg tgatcttatt 135781 ccggtaactg ttatcgaggc tgctccaaac gttgttcttc aaaagaaaac agctgaaaac 135841 gacggttacg aagcaatcca gcttggtttt gacgacaagc gtgaaaagct ttctaacaaa 135901 cctgaaaaag ggcacgttgc aaaagcggaa actgctccta agcgcttcgt taaagaatta 135961 cgcggagtgg aaatggatgc gtatgaagtt ggtcaggaag tcaaggttga aattttctct 136021 gctggagaaa tcgtagatgt aacaggagta tctaaaggta aaggtttcca aggtgcgatc 136081 aagcgccacg gacaatctcg cggacctatg tctcacggtt cacgctacca ccgtcgtcct 136141 ggttcaatgg gacctgtaga tcctaaccgt gtattcaaag gtaaattatt acctggacgt 136201 atgggcggag agcaaatcac tgttcaaaac cttgaaatcg taaaagttga tgcagaacgc 136261 aatcttcttt tgatcaaagg taacgtacct ggtgcgaaga aatctttaat cactgttaaa 136321 agtgctgtta aatctaaata attctcttag gaaaggagga aattgattat gccaaaagta 136381 gcattataca accaaaacgg ttctactgct ggtgacatcg aattaaacgc ttctgtattt 136441 ggtatcgaac caaatgagag tgttgtattc gacgctattc ttatgcaaag agcttcctta 136501 cgtcaaggaa ctcacaaagt aaaaaatcgt tctgaagtac gcggcggagg tcgtaaacca 136561 tggcgtcaaa aaggtactgg acgtgcccgt caaggttcaa tccgttcacc gcaatggcgc 136621 ggaggtggtg tcgtattcgg cccaacacca cgcagctatt cttataaatt acctaaaaaa 136681 gttcgccgct tggcaatcaa atcagtattg tcttctaaag tgatcgacaa caacatcatc 136741 gttcttgaag atcttactct tgatacggct aaaacaaaag aaatggcagc tatccttaaa 136801 ggattatctg ttgagaaaaa agctttaatc gtaactgcgg atgcaaacga agcagtagca 136861 ttatctgctc gtaacattcc tggagttact gttgttgaag ctaacggaat caacgtttta 136921 gacgttgtca accacgagaa gcttctgatt acaaaagcag cggttgaaaa agtagaggag 136981 gtgcttgcat aatgaaagat cctcgtgatg ttctaaagcg ccccgtcatt actgaacgtt 137041 ctgccgattt aatgactgaa aaaaaatata cttttgaagt tgatgtaaga gctaacaaaa 137101 cagaagtgaa agacgcggtt gaaagcatct ttggagtgaa agttgacaaa gtcaacatca 137161 tgaactacaa aggcaaatca aaacgtgttg gacgctacac tggtatgact agccgtcgca 137221 gaaaagcgat cgtaaaactt actgcagaca gcaaagaaat cgaaattttt gaagcttaat 137281 tatctgtaaa aagaaggagg gaaattcaaa atggcgatta aaaagtataa accgacctct 137341 aatggacgtc gtggcatgac aacttcagat tttgctgaaa tcacgactga caagccggaa 137401 aaatccttgc ttgctcccct tcacaaaaaa ggcggacgta acaaccaagg taaattgact 137461 gtacgtcacc aaggtggcgg acataaacgc caataccgtg ttatcgactt caaacgcgat 137521 aaagatggta tacctggacg cgttgctaca gttgaatacg atccaaaccg ttcagctaac 137581 atcgctctaa tcaactatgc agacggagaa aaacgttaca ttcttgctcc taaaggaatt 137641 caagtaggta ctgaaatcat gtcaggtcct gaagctgaca ttaaagtagg taatgcactt 137701 ccacttatca acatccctgt tggtacagtt gtgcataaca ttgaattaaa acctggtaaa 137761 ggcggacagc ttgtacgttc agctggtaca tctgctcagg ttcttggtaa agaaggtaaa 137821 tacgttcttg tacgtcttaa ctctggtgaa gttcgcatga tcctttctgc ttgccgtgct 137881 tctatcggtc aagtaggtaa cgaacagcac gaacttatca acattggtaa agctggacgt 137941 tctcgctgga aaggcatccg tcctacagtt cgtggttctg taatgaaccc taacgatcac 138001 ccacacggtg gtggtgaagg acgtgcgcca atcggacgta aatcaccaat gtctccatgg 138061 ggcaaaccaa ctcttggatt caagactcgt aagaaaaaga acaaatccga taaatttatc 138121 gtacgtcgtc gtaaaaataa ataacggggt tgtctacggt tcttttcgga ccgtagtgca 138181 atcacgaagg gaggttccaa aatggctcgc agcttaaaaa aaggaccatt tgtcgatgga 138241 cacttgatga ctaaaatcga gaaattaaat gaaacagaca agaaacaagt cgtaaaaact 138301 tggtctcgtc gttctactat tttcccacag tttattggtc acacaatcgc agtctatgac 138361 ggacgtaaac acgtgcctgt attcatctct gaagatatgg tagggcacaa gttgggtgaa 138421 ttcgctccaa ctcgtacgta caaaggtcat gctagtgatg acaaaaaaac aagacgctaa 138481 gagaggaggc ttttaaatgc aagctaaagc tgttgcaaga acagtccgta ttgctcctcg 138541 taaagcacgt ctagtaatgg acctgattcg aggcaagcaa gtaggtgagg cagtatcaat 138601 cttgaacctt acaccaagag ctgcttctcc aattatcgag aaagtattaa aatccgctat 138661 tgcaaatgct gagcataact atgaaatgga cgctaacaac ctggttattt ctcaagcatt 138721 cgttgacgaa ggccctacgt taaaaagatt ccgcccacgt gctatgggac gtgcgagcca 138781 aatcaacaaa cgtacgagcc acattacaat cgttgtatca gaaaagaagg agggataagt 138841 agtgggtcaa aaggtaaatc cagtcggtct tcgtatcgga gtcattcgtg attgggaatc 138901 taagtggtac gctggtaaag attacgctga cttcctgcac gaagatttaa aaattcgtga 138961 atacattagc aaacgccttt ctgacgcttc tgtttctaaa gtagaaattg agcgtgcagc 139021 aaaccgcgtt aacattacga tccacacagc taagcctggt atggttatcg gtaaaggcgg 139081 ttctgaagtc gaagcacttc gcaaagccct taacagcctt actggcaagc gtgtacacat 139141 taacattctt gaaatcaaaa gagcagatct tgatgcacag ctagttgctg acaacatcgc 139201 tcgtcaatta gaaaaccgtg tttctttccg ccgtgcgcag aaacaacaaa tccaacgtac 139261 tatgcgtgct ggagcacaag gtgtgaaaac aatggtttct ggtcgtcttg gcggtgcaga 139321 tatcgctcgt tctgaatact acagtgaagg aactgttcca ttgcacacat tacgtgcgga 139381 cattgactat gcaacatctg aagctgatac tacttacggt aagcttggtg taaaagtctg 139441 gatctatcgt ggagaggttc ttcctactaa gaagaaaaat gaggaaggag gaaaataata 139501 tgttattacc aaaacgcgtt aaatatcgca gagagcatcg cggaaaaatg cgtggccgtg 139561 cgaaaggcgg tactgaagta catttcggag aattcggtat ccaagctcta gaagcttctt 139621 ggattactaa ccgtcaaatc gaagctgcac gtattgcgat gactcgttac atgaaacgtg 139681 gcggtaaagt ttggatcaaa attttccctt ctaaacctta cactgctaaa ccacttgagg 139741 tacgtatggg atccggtaaa ggggctccag aaggttgggt agctgttgta aaaccgggca 139801 aagttttatt tgaaatttct ggtgtgtctg aagaggttgc tcgtgaagcg cttcgccttg 139861 catctcacaa attgccaatt aaaacgaagt tcgtaaaacg tgaagaaatt ggtggtgaat 139921 caaatgaaag ctaatgaaat tcgtgacctt accactgctg aaattgaaca aaaagtaaag 139981 tctcttaaag aagaactttt caatcttcgc tttcaattag cgacaggaca acttgaaaat 140041 actgctcgca ttcgtgaagt gcgcaaagct atcgcgcgca tgaaaactgt gattcgtgaa 140101 agagaaattg ctgctaataa ataatcactg aggggaggtc gtgagcatga gcgaacgtaa 140161 ccaacgcaaa gtttaccaag gccgtgttgt ttctgacaaa atggataaaa ccattactgt 140221 tgttgttgag acatacaaaa aacatacact ttacggtaaa cgcgtaaaat actcaaaaaa 140281 attcaaagca catgatgaaa ataatcaagc taaaatcggt gacatcgtta agatcatgga 140341 aactcgtcca ttgtctgcaa ctaagcgttt ccgtctagtt gaagttgtcg aagaagctgt 140401 tattatctaa taaagttcgg aattcttttt ccgaagggag gtaacaaata atgattcaac 140461 aagagactcg tttaaaagta gctgacaact ctggcgcacg tgaagtactt actattaaag 140521 ttcttggtgg ttctggacgt aaaacagcta acattggtga tgtaattgtt tgcacggtta 140581 aacaagcaac accaggaggc gttgtcaaaa aaggtgaagt cgtaaaagct gttatcgttc 140641 gcactaaaag cggagcgcgc agaagtgacg gttcatacat cagcttcgat gagaatgcat 140701 gtgttatcat ccgtgacgac aagagcccac gcggaactcg tatcttcgga ccagttgctc 140761 gtgaattgcg tgaaaacaac tttatgaaaa ttgtttctct agctccagaa gttatctaat 140821 tgaaataaat gccttactca aggaggtgcg atcaggatgc atgtaaaaaa aggcgataaa 140881 gttatggtta tctctggtaa agataaaggc aaacaaggaa caatccttgc tgctttccct 140941 aaaaaggacc gcgttttagt tgaaggtgtt aacatggtaa agaaacactc taaaccaact 141001 caagctaacc ctcaaggcgg tatttctaat caagaggcgc caattcatgt atcaaacgtt 141061 atgccgctcg atcctaaaac aggtgaagtg actcgcgtag gatacaaagt ggaagatggc 141121 aaaaaagttc gtgtagcaaa aaaatctggg caagttctag ataaatagta ttaaaaggaa 141181 gggaggtcta tctcatgaac cgccttaaag aaaagtacaa taaagaaatt gcacctgctt 141241 taatgactaa gttcaactat gattcagtca tgcaagtgcc taaaatcgaa aaaatcgtaa 141301 tcaacatggg tgttggtgac gctgttcaaa acgccaaagc aatcgacagt gctgttgagg 141361 aattaacgtt tatcgcaggt caaaaacctg tcgttactcg tgcgaagaaa tcaattgctg 141421 gattccgtct tcgtgaggga atgcctatcg gtgcgaaagt aactcttcgc ggagagcgca 141481 tgtatgattt ccttgataaa cttatttctg tatctttacc gcgtgtacgt gacttccgcg 141541 gggtttctaa aaaatctttc gacggtcgcg gtaactacac acttggtatc aaagaacagt 141601 taatcttccc tgaaattgac tacgataaag taacaaaggt tcgcggaatg gacatcgtta 141661 tcgtaacaac tgctaatact gacgaagaag ctcgtgagct attaactcaa gtaggtatgc 141721 cgttccagaa ataatcaatg aaagggaggc gaaatcgtgg ctaaaaagtc tatgattgcg 141781 aaacaacaac gtacaccaaa gtttaaagta caagagtaca cacgctgtga acgctgcgga 141841 cgtccgcatt cagtcattcg taaatttaaa ctttgccgta tttgtttccg tgagcttgca 141901 tataaaggac aaattcctgg cgtgaaaaaa gccagctggt aatccccaag aaagggaagg 141961 aggtaattat ataatggtta tgacagatcc aattgcagat atgctaactc gtattcgcaa 142021 tgcaaacatg gtacgtcatg agaagcttga aattcctgct tctaaattga aaagagaaat 142081 tgctgaaatt ttaaagcgtg aaggtttcat tcgtgacgtt gagttcgtag aagacagcaa 142141 acaaggtatt atccgcgttt tcttgaaata cggacaaaac aacgagcgcg ttatcactgg 142201 tcttaaaaga atcagcaagc ctggtttgcg tgtttatgct aaatctaatg aagtaccccg 142261 cgtacttaac ggtcttggaa tcgcgattat ttctacatca caaggtgttt taacggacaa 142321 agaagcccgt gcaaaacaag ctggtggaga agttctagca tacgtttggt aagaagttta 142381 acatgaatgg aggtgtttgg tatgtctcgt gtaggtaaga agctacttga gattccttct 142441 gatgttacag taacgttaaa tgataacaac actgtagctg tgaaaggacc aaaaggagaa 142501 ttaactcgta cgtttcaccc tgatatggag attaaagtag aggacaatgt gcttacagtc 142561 gctcgtcctt ctgatcaaaa agagcaccgt gccctgcatg gtacgactcg cagtctgctt 142621 ggcaacatgg ttgaaggtgt atctaaagga tttgaaagag gtttggaatt agtcggtgtc 142681 ggttaccgtg cttctaaatc cggaaataaa cttgttttaa acgttggata ctctcatcct 142741 gttgagatcg ttcctgaaga aggcatcgaa atcgaagttc cttctcaaac aaaagtagtt 142801 gtaaaaggta cagacaaaga acgcgtagga gctattgctg ctaacatccg cgctgtacgt 142861 tctccagagc cttacaaagg taaaggaatc cgctacgaag gtgaagttgt tcgccgtaaa 142921 gaaggtaaat ctgctaagta agatcgctta aagtgaagaa aggagtgacc tagatgatta 142981 cgaaaactag caaaaatgct gctcgtctta aaagacacgc tcgtgttcgc gctaaacttt 143041 ccggtactgc tgaaagaccg cgcctgaacg ttttccgttc taacaagcac atttacgctc 143101 aaatcatcga tgatgtaaat ggtgtaacac ttgctagtgc atctactctc gataaagact 143161 tgaacgttga aagcactgga gatacttctg ctgctactaa agttggagaa ttagttgcaa 143221 aacgcgctgc tgaaaaaggc atttctgacg tagtatttga ccgtggcgga tacttatacc 143281 atggacgtgt aaaagctttg gctgatgccg ctcgtgaagc tggacttaaa ttttaataaa 143341 agaaggaggg acacatgatt atgcgtcgta ttgacccaag caaattagag ttagaagaac 143401 gcttagttac ggttaaccgc gtagcgaaag ttgttaaagg tggtcgtcgt ttccgcttcg 143461 cagctctagt cgttgtcggt gacaaaaacg gacacgtagg attcggtact ggtaaagcac 143521 aagaagtacc agaagcgatt cgcaaagctg ttgaagatgc gaaaaagaat ttgattgaag 143581 taccaatggt tggaactaca attccacacg aaatcatcgg acgtttcggt gcaggtaaca 143641 tcttgttaaa acctgcttct gaaggtactg gagttatcgc tggaggccct gtacgtgcgg 143701 tacttgagct agctggtgta gctgatatcc tttctaagtc tttaggttct aacacaccga 143761 tcaacatgat tcgtgcaaca cttcaaggtt taagtgaact taaacgtgct gaagacgttg 143821 cgaagcttcg tggaaaatct gtagaagaac tgttaggata aggagggaac attaatggct 143881 aaattagaaa ttaccctcaa acgaagtgta atcggtcgcc cggaagacca acgcgttact 143941 gtaagaacac ttggtttaaa gaaaacaaac caaactgttg ttcatgaaga caacgctgcg 144001 atccgtggta tgattaataa agtatctcat ttagtttctg ttaaagaaca ataaaaatat 144061 ttgatcggat aaggaggtgt cctaatgaaa cttcatgaat taaaaccttc agaaggttca 144121 cgcaaaacgc gtaatcgcgt aggtcgtggt attggttctg gcaacggtaa aacagctggt 144181 aaaggtcaca aaggtcaaaa cgctcgttct ggcggcggtg tacgccctgg attcgagggg 144241 ggacaaatgc ctttattcca acgtcttcct aaacgtggtt tcactaacat caaccgcaag 144301 gaatacgctg tagtcaacct agacaaattg aacggttttg cagaaggaac ggaagtcact 144361 cctgaacttc ttctagagac tggtgttatt agcaaactta atgcaggagt aaagattctt 144421 ggcaacggta aattagagaa aaaattaact gtaaaagcca ataaattctc tgcttctgcg 144481 aaagaagctg ttgaagctgc tggcggtaca gctgaggtga tctaacttgt ttaaaacaat 144541 ctccaacttt atgcgtgtga gtgatatcag gaataaaatc atattcactt tactcatgct 144601 tatcgtcttt cgcataggtg cgtttattcc tgtgccttac gttaacgctg aagcgttaca 144661 ggcacagtct caaatgggtg tttttgatct ccttaataca tttggcggcg gtgcgcttta 144721 ccaattttcc attttcgcaa tgggaattac tccttatatc acggcttcga tcatcattca 144781 gctgcttcag atggatgtgg taccgaagtt taccgagtgg tctaagcaag gtgaagttgg 144841 ccgccgtaaa ttagctcagt tcacaaggta ctttacgatt gtgcttggtt tcatccaagc 144901 gttaggtatg tcatatggat tcaacaatct ggcaaacggt atgctgatcg aaaaatccgg 144961 tgtatcgaca tatcttatca ttgctttagt gctcactggc ggaactgcct ttttaatgtg 145021 gcttggggaa caaattactt ctcatggagt aggcaacgga atatcgatca ttatcttcgc 145081 ggggattgtg tctagtattc caaaaacaat tgggcaaata tatgagactc aatttgtcgg 145141 cagcaacgat cagttgttta ttcatattgt gaaagtcgca cttcttgtga ttgcgatttt 145201 agcagttatt gttggagtta ttttcattca gcaagccgta cggaaaattg cgattcaata 145261 tgctaaaggc acaggtcgtt cacctgctgg cggaggtcag tctacacacc ttccattgaa 145321 agtgaatcct gcaggggtta ttccggtaat ctttgcggtt gcgtttttga taacgccgcg 145381 gacgatcgcg tcattctttg gaacaaacga tgtgacaaag tggattcaaa acaactttga 145441 taatacgcat ccggtgggta tggcgatata tgttgcgttg attattgcct ttacgtactt 145501 ttatgctttt gtacaggtaa accctgaaca aatggctgat aaccttaaaa aacagggtgg 145561 ctatatcccg ggggttcgtc cagggaaaat gactcaagat agaattacga gcattttgta 145621 tcgacttacg tttgtgggtt ctatattctt agccgtgatt tccattcttc ctatcttttt 145681 cattcaattc gctggattgc ctcaaagtgc acaaattggc ggaacatctt tgttaattgt 145741 tgtcggggta gccttggaga caatgaaaca actagaaagc cagttggtga aacgaaacta 145801 ccgtggattt atgaaaaact agaggaaatg gatttatcca ttccctctta ataaagagag 145861 gacgggggaa atccgaatga acttagtctt aatggggctt cctggtgccg gtaaaggcac 145921 acagggcgaa cgaattgttg aggattatgg gattcctcat atctcaacag gagatatgtt 145981 ccgtgctgct atgaaagaag aaacaccact cggactcgaa gcaaaatctt atattgataa 146041 gggagagctc gtacctgacg aagtcacaat cggaattgta aaagagagac ttggcaaaga 146101 tgattgtgaa agaggttttc ttctggacgg atttccgcga acagtcgctc aagccgaagc 146161 tcttgaagaa attcttgagg aatacggcaa gccgattgat tatgtcatta acattgaagt 146221 cgacaaagat gttctgatgg aacgtctgac tggacgcaga atttgcagtg tttgcggcac 146281 aacctatcat ttagtcttta atccgccgaa aacgccgggt atttgtgata aagacggagg 146341 cgaactctat caacgggcag atgataatga ggaaacagtc tctaaacggc ttgaggtaaa 146401 catgaagcaa actcagcctt tactcgattt ctattcagag aaaggttatc ttgcaaacgt 146461 gaatggccag caggacattc aagacgttta tgcagatgtg aaggatcttc ttggaggatt 146521 aaaaaaatga ttatctgtaa aaccccacgt gaacttggta tcatgcggga agcagggcga 146581 atcgtggctt taactcatga agagttaaaa aagcacatta aaccaggaat ctcgacaaaa 146641 gaattggatc aaattgccga acgttttatt aagaagcagg gtgcaatccc atcttttaag 146701 gggtataatg ggtttcgcgg gagcatttgc gtatcagtta atgaagaact cgttcacggc 146761 atacctggca gcagggtgct gaaggacggt gacatcatca gtattgatat cggtgctaaa 146821 ttaaatggtt atcatggtga ctctgcatgg acatatccgg taggaaacat cagcgatgat 146881 gacaaaaaac ttctggaagt gacagaggag tctttatata aaggcttgca ggaagcaaaa 146941 ccaggtgaac gtttgtcgaa tatttcccac gcaatacaaa cgtatgtcga aaatgagcag 147001 ttttcagttg ttagggagta tgtcggacat ggtgttggtc aagacttgca tgaggacccg 147061 caaattcctc attacggtcc gcccaacaaa ggaccacggc ttaaacctgg catggttctc 147121 gctattgaac ctatggtgaa cgctggcagc cgctacgtga aaacattggc tgataactgg 147181 acggttgtaa cggtagatgg gaaaaagtgt gctcattttg aacatacgat tgcgattacg 147241 gaaacgggtt ttgatatact gacgagagtc tagatgatga aaataattcc gaagacagat 147301 gtttttcaag cttgataggg cagaaagctt gggtgaacat tggcaagacc gaattcatct 147361 tgcttcttgt cgttggaatt ttaaccatca tcaatgtact aacagcagac ggagaaaagc 147421 gtacatttca ttctcctaag aaaaagaata tcaatcattt aaccctttat gattgcgtat 147481 ctccggaagt tcagaacagt ataaacgaaa cagggcgtgt gacaaacttc ttttgaaatt 147541 tgtcagaaag caagttactg atttgaagaa gggagaacac ttgaatggcg aaagacgatg 147601 taattgaagt ggaaggtact atagtcgaaa cactgccaaa cgcgatgttc aaagttgaac 147661 ttgaaaatgg ccacactgtt ttggctcatg tatctggtaa aatccgcatg cacttcattc 147721 gcattttacc tggagacaaa gttacggtag aattatctcc atatgactta actcgtggca 147781 ggattacgta ccgttacaaa taaagcactc cggaaactga aggaggttgg aaacacatga 147841 aagtgagacc atcagttaaa ccaatctgcg aaaaatgtaa agttattcgc agaaaaggaa 147901 aagtaatggt gatctgtgaa aatccaaagc ataaacaaaa acaaggataa tttataagga 147961 ggtgcccaga gaatggctcg tattgctggt gtagatatcc cacgtgacaa acgtgttgtt 148021 atttctttaa catacatctt cggaattggc cgcacaacgg ctcagcaagt tttaaaagaa 148081 gctggagttt cagaagatac tcgtgtgcgc gatcttactg aagaagaact tggtaaaatc 148141 cgtgatatta ttgacaaact gaaagtagaa ggtgaccttc gccgtgaagt ttctcttaat 148201 atcaaacgtc tgatcgaaat cggaagctac cgcggaatcc gtcatcgcag aggattacct 148261 gttcgcggac aaaactctaa aaacaacgcg cgtactcgta aaggtccgcg tcgtactgta 148321 gctaacaaga aaaaataagt aagggaggtt cttaaacaat ggctgctgct cgtaaatcta 148381 acacgcgtaa acgtcgcgtg aaaaagaata ttgagtctgg aattgctcat attcgttcaa 148441 ctttcaataa cacgatcgtt acgatcactg acactcatgg taatgctatt tcttggtcta 148501 gtgccggagc tttaggattc agaggttctc gtaaatctac tccttttgct gcgcaaatgg 148561 ctgcagaaac agctgctaaa ggttcaatcg aacatggtct taaaactcta gaggttactg 148621 ttaaaggacc tggttcaggc cgtgaagctg caatccgtgc acttcaagct gctggactag 148681 aagtcactgc tatcagagac gtaactcctg ttcctcataa cggatgccgt ccaccaaaac 148741 gtcgccgcgt gtaatttgtt tgtatagatt ttgtgtccct gtcaataatg ggttatgata 148801 cagttattta tgaaacgaat gcaccgactc gttgcctgag cacatacggg actaaacaat 148861 ggggaatttc ggatggaatc tcatatgatt ctattcgagg tttcgacgtt ttgaaggagg 148921 gttttaagta atgatcgaga ttgaaaaacc aaaaatcgaa acggttgaaa tcagcgacga 148981 tgccaaattt ggtaagtttg tcgtagagcc acttgagcgt ggatatggta caactctggg 149041 taactcctta cgtcgtatcc tcttatcctc actccctggt gccgctgtaa catcaatcca 149101 gatagatggt gtactgcacg aattctcgac aattgaaggc gttgtggaag atgttacaac 149161 gattatctta cacattaaaa agcttgcatt gaaaatctac tctgatgaag agaagacgct 149221 agaaattgat gtacagggtg aaggaactgt aacggcagct gatattacac acgatagtga 149281 tgtagagatc ttaaatcctg atcttcatat cgcgactctt ggtgagaatg cgagtttccg 149341 agttcgcctt actgctcaaa gaggacgtgg gtatacgcct gctgacgcaa acaagagaga 149401 cgatcagcca atcggcgtga ttccgatcga ttctatctat acgccagttt ctcgtgtatc 149461 ttatcaggta gagaacactc gtgtaggcca agttgcaaac tatgataaac ttacacttga 149521 tgtttggact gatggaagca ctggaccgaa agaagcaatt gcgcttggtt caaagatttt 149581 aactgaacac cttaatatat tcgttggttt aactgacgaa gctcaacatg ctgaaatcat 149641 ggttgaaaaa gaagaagatc aaaaagagaa agttcttgaa atgacaattg aagaattgga 149701 tctttctgtt cgttcttaca actgcttaaa gcgtgcgggt attaacacgg ttcaagagct 149761 tgcgaacaag acggaagaag atatgatgaa agttcgaaat ctaggacgca aatcacttga 149821 agaagtgaaa gcgaaactag aagaacttgg actcggactt cgcaaagacg attgactagt 149881 ttcccttgtg aactaggatt ttcgtgtgtt tattattcag aaacagcatt ccaataaagg 149941 aggggacatc acatgtcata cagaaaacta ggacgtacga gtgcacagcg taaagctatg 150001 cttcgtgatc ttacaactga tttgatcatc aacgaaagaa tcgaaacaac tgaaacacgt 150061 gcgaaagaac ttcgctctgt agttgaaaaa atgatcacgc ttggcaaacg cggtgatctt 150121 cacgctcgcc gtcaagctgc tgcatacatc cgcaacgagg ttgcaaacga agaaaataat 150181 caagatgcac ttcaaaaatt attctctgac attgcaactc gttacgagga gcgccaaggt 150241 ggatacacac gtattatgaa gcttggtcct cgccgtggtg acggagcacc aatggcaatt 150301 atcgaattgg tttaatcaca tatttttgtg tatctaaaga agggcgggac agtttctaac 150361 tggatctatg cccttttttt agatactgca acttttaata gagagaaaag cagagcatta 150421 gctgagagga ggccggtttt ccatgaatca aaatcagttg atatcggtag aggatatcgt 150481 atttcgatat cggaaggacg cagaaagacg agcactagac ggcgtctccc tgcaggtgta 150541 tgagggtgaa tggcttgcaa tcgtaggtca taacggttca gggaaatcaa cactggcccg 150601 ggcattgaat ggtttaattc ttcctgaatc aggcgacatt gaggttgccg ggattcaatt 150661 gacagaggaa tctgtttggg aagtgcgtaa gaagataggt atggtctttc aaaatccgga 150721 taaccaattt gtcggaacga ctgttcgcga tgatgtggct tttggtttag aaaacaatgg 150781 tgtaccgcgg gaagaaatga ttgagagagt agactgggca gtaaaacagg tgaatatgca 150841 agattttctc gatcaagagc cgcaccatct ctccggaggc caaaagcaga gagttgcgat 150901 tgcgggggtt attgccgcac gtcctgatat tattatctta gatgaagcaa catccatgct 150961 tgatccgatc gggcgagaag aagtgcttga aacggtaaga catttaaaag agcagggcat 151021 ggcgactgtc atatccatta cacatgacct gaatgaggca gcaaaagcag acaggatcat 151081 tgtcatgaat ggcggtaaaa aatatgctga agggccgcct gaagagattt ttaaattgaa 151141 taaagaactt gttcgaattg ggcttgattt acccttctca ttccagctta gccagctttt 151201 aagagaaaat ggactggctt tggaagaaaa ccatttgact caggaagggc tggtgaaaga 151261 gctgtggaca ttacaatcaa agatgtagag catcgctatc agatgaagac cccgtttgag 151321 cgcctagcac tgtatgatat caatgcatcg attaaagaag gaagctacgt agccgttatc 151381 gggcatacag gctctggcaa gtccactctt ctacagcacc taaatggtct cctgaagccg 151441 acgaagggac agatatcact aggcagcact gtcattcagg cagggaaaaa gaataaagat 151501 ctgaaaaaac ttcgtaaaaa agtcggaatc gttttccaat ttcctgagca tcaattattc 151561 gaagaaacag ttcttaaaga tatttcattc ggaccgatga actttggtgt taaaaaagaa 151621 gatgctgaac aaaaagcgag agagatgctg cagcttgtag gtttatcaga agagcttttg 151681 gacaggtcac cctttgaatt aagcggggga caaatgcgca gagttgcaat tgccggcgta 151741 cttgcaatgg accctgaagt gcttgttctg gatgaaccga ctgcaggatt ggacccaaga 151801 gggcgaaaag agattatgga catgttttat gagcttcatc aacgtgggaa cttgacgacg 151861 atccttgtga cacacagcat ggaggatgca gctgcatacg ctgatgaaat gattgttatg 151921 cataaaggaa cgatacaagc atcaggcagt ccgcgtgatc tgtttttaaa gggtgaagag 151981 atggccggct gggggctgga tcttcctgaa acaataaaat tccaaagaca ccttgaagct 152041 gcactgggtg tgagatttaa tgagcctatg ctcacaatcg aagatgccgc tgccgaaatc 152101 cgtgctcttt ttcagggaga gaagacttta tgatggacag catgattatc ggcaagtatg 152161 taccggggac ttcacttgtg caccggcttg accccagaac aaaactgatc acgatctttt 152221 tatttgtctg cattgtattc ttagccaata atgttcagac atatgcgttg cttggtttat 152281 ttacaattgg cgtcgtttct ttaacaagag ttcctttctc ttttttaatg aaagggctga 152341 agccaatcat ctggattgtc ctttttacgt tccttcttca cattcttatg acacatgaag 152401 gaccgattat ctttcaaata ggttttttca aagtctatga gggcggtctg gttcagggga 152461 tattcatttc tcttagattc gtctatttga ttttaatcac aaccttatta acgcttacga 152521 ctacaccgat tgagattacc gatggaatgg agcagctgct gaacccattg aaaaaattaa 152581 agcttcctgt tcatgagctg gctcttatga tgtcaatttc tttacggttt attccgacac 152641 tgatggagga gacagataag atcatgaagg ctcagatggc gcgaggcgtt gattttacaa 152701 gcgggcctgt caaagaaaga gtgaaggcta ttgtcccgct tcttgtcccg ctcttcgtca 152761 gcgcatttaa acgcgccgaa gagcttgcgg tggcaatgga agcaagaggc tatcaaggcg 152821 gagaaggacg tacgaaatat agaaagcttg tatggacagg aaaagacact tctgtcattg 152881 tcagcttaat tgtattagct gctttgttat ttttcttaag ggcttagagg tgctgtatga 152941 gactgaaatg cacgatttct tatgacggac atttgtttaa cggttatcag gttcagccgg 153001 gcaaaagaac ggttcaggat gaactggaga aggctttggc tgtcctgcat aagtcaaaag 153061 acagaattcc ggtcgtttcg tctggaagaa cagacagcgg ggttcacgca gccggacagg 153121 tgattcattt tgacactccg ctgtctatcc cggctgagag atggccatat gccttaaatg 153181 cactgcttcc ggacgatatc gcagtcaaac aggcagaaat tgcggatgat gggttccatg 153241 cacgatttag cgcagtcaaa aaagaatatc gctactttgt atacacggag aaacacccgg 153301 acgtatttaa acggcattac gcttaccatt tttcatatcg ccttaatgtg caggacatga 153361 gagaagcggc aaagcatctt atagggacac atgattttac gagcttttgc gcggctaaaa 153421 cagaagtgca ggacaaggta agaacgatat acgaacttga ttggactgag acggctgacg 153481 gcctgcaaat gcggatcaca ggcagcggtt tcttatataa tatggtcaga attattgcgg 153541 gtactttgct tgatgcaggt attggaaaaa tttctcccga tgaggtgaaa tccatgctgg 153601 aagcgaagga tcgcgaagcg gcagggcgca cagcgccggg gcacgggcta tatttatgga 153661 acgtttacta tgacaactaa accaggtgta taatattttc ttgacagagt ctgcataaag 153721 ttataagata tcatatggta tgtatttcaa ccccacgata agccccggaa cttattgtgt 153781 tgtgaaatag aacgtaatcg aagtttattg aaaatgacag atcatttagg agggaaattc 153841 aatgcgtaca acacctatgg ctaacgcaag tactattgaa cgcaagtggt tagttgttga 153901 tgctgctggc aagactttag gtcgtctttc ttcagaagtt gcagctatcc ttcgcggaaa 153961 acacaaacca acttacacac cacacgttga tactggagat catgtgatca tcatcaacgc 154021 tgaaaaaatc gagttaactg gtaaaaagtt aactgacaaa atctactacc gtcacactca 154081 acatccaggc ggattaaaat caagaactgc tcttgaaatg cgtacaaact accctgagaa 154141 aatgcttgag cttgctatca aaggcatgct tccaaaaggt tctctaggtc gtcaaatgtt 154201 caaaaaattg aacgtatacc gtggttctga gcatccacac gaagcacaaa aacctgaagt 154261 ttacgaactt cgcggttaat taaaaaggag gttaccaatt tggcacaggt tcaatattac 154321 ggtactggcc gtcgtaaaag ctctgtagcg cgtgtgcgtt tagttccagg agaaggccgt 154381 atcgtcgtta ataatcgtga aatcagcgaa catatcccat ctgcagcttt aatcgaagat 154441 atcaaacaac cattaacttt gactgaaaca gctggcactt atgatgtttt agtaaacgta 154501 catggaggcg gcctatctgg tcaagctgga gcaatccgtc acggtatcgc tcgtgctttg 154561 cttgaagcag atccagaata ccgtacaact cttaaacgtg caggtcttct gactcgtgac 154621 gctcgtatga aagaacgtaa aaaatacggt cttaaaggcg ctcgtcgtgc acctcagttc 154681 tcaaaacgtt aattttacgt tttcaaaaag ctctcgacct tgggttggga gcttttttct 154741 ttcaataaaa cgtggcagtc ccgcataaaa ataacaactg aatggacgct tgacggggtt 154801 aagcaaattg tttgtttata aacggtctct ttgtaataat catggtagat ttcattctta 154861 ttcaattgga agttcggtca atgtttatta tcgttatgtg atcagcccag ctccatctaa 154921 ccactgtatc tcatccgtta aagttcactg ctgattctta acccggagaa acaatagctc 154981 tcattgctaa tggctttatg taacgaagta aaagtaaatc tgatgatata aatcacatat 155041 ctcctttgtg atttttttgc gtttttatga acttttttct aaatatgcaa agggaaagcg 155101 atatcaatct agaaatattt gttatactct atacattaaa gtaaggagaa gattcatgaa 155161 tgcgttagta gctcataata gcaaagcctg ggataaaaaa gtagaaacag gcaatgaatg 155221 gactgttgct gttgaacagc aggttatcga acaagcaaaa aaaggcaatt gggatataag 155281 ggtaacacca atgaaagatg taccgaagga ttggtttccg cctatcaaag gtctgaaagt 155341 actctgttta gcatcaggcg gcggccagca gggtccagtt ttggcagccg caggcgcgga 155401 tgtcactgta ttagataact cagaaaaaca gctgaatcag gatagaatga ttgctgagcg 155461 agatggtctg acgatacaca ctgtcaaagg aagcatggac gatttaagtg tatttaatga 155521 tgaatcattt gatgtcattg tacatcctgt tgccaatgtt tttgttgaga atgtcctccc 155581 ggtatggaag gaagcgtacc gtgtgttgaa aaggaacggc attctaatct cgggttttgt 155641 caatcctgtt gtatttctgt ttgatacaga attagaacag caaggtgttt taaaagtaaa 155701 acactctatt ccatacgctg acccagaaga tcttccgaaa cataaagtga aaaaactgat 155761 cgaaaataat gaggctctgg aattcggcca ttccttagaa gaccaaatca aaggccaaat 155821 tgatgccggt tttatcgtta ctggttttta tgaagataaa ggcggttttg tattagacca 155881 atatatccat acatattctg caacaagaag cgtgaaagta tgaaaagcag cgacctgtta 155941 gaggggctgc ttttttcata accaattaca gaacatttgt tcctcaccct gcagaaagct 156001 gattttttat caatgttaca ccttcatttg ggcgaatttc caaccgaatt cgggcattgt 156061 ttcatcatcc aaacctcaaa ataatcggta aaaggagagt gaatttatat ggcagaagta 156121 ctgtctttta tggatgtgaa acgccaaaag gattttgaat tagaaaagaa cttgctcaaa 156181 gaactctctc tgagacaaat tatccagtct gttaaggatt gtttggaacc attatttcca 156241 tttttacatg atgaacgaga tattattacc gaaggctgta ttgattttgc gattgaagct 156301 tatttgttag gcgggcgttt tgggatattc ggctattacg gagaatcaat gcagagtatc 156361 agtgcccgct ctgcaagaga agaagaagag ctgcgtatgg agttttttga ttatctctat 156421 aattggatac acgagcaata cgcaacattt gataaaaaca ctgtttatga agcggcacgc 156481 aagttcatta aagattggtg gacagcaggg tttgttcaaa gagaaaaaca gtgtaagctt 156541 cgcatgcggt aatcatattt cccgaccctg tcccatagtt atgtaataac ggacaagcgg 156601 gaggggaagg gatgaggaaa aagcttaaat ggctcagttt tttgctaggc ttcatcatat 156661 tactatttct gttcaagtat cagttcagca ataacgactc ttggaagccg tggagcctgc 156721 ccttgagcgg taaaatcatt tatctagatc caggtcatgg cgggcctgac ggcggagcag 156781 tcggcggaaa gctgttagag aaggatgtta ccctggaagt ggcctttaga gtcagggatt 156841 atcttcaaga acaaggagcg cttgttatca tgaccagaga aagtgatact gatctcgctc 156901 cagaaggaac aaaaggctat agccgacgaa aagctgagga tctaagacaa cgagtcaaat 156961 taataaacca ttcagaggcg gagctctata tcagcattca tcttaatgcg attccgtcac 157021 aaaaatggag cggagcccaa agcttttatt acgggaaata tgcggaaaat gagaaagtcg 157081 caaaatacat tcaggatgag ctgagaagaa atctggaaaa cacaacccgg aaagcaaagc 157141 ggattcatgg tatctactta atgcaaaacg tcaccaaacc gggggcgctt atagaagtcg 157201 gatttttatc caatccaagt gaagcaacgt tgctcggtaa accgaaatat caagacaagg 157261 tggcatcttc catatataaa ggcattttgc gatatttcac agaaaaagga gaccctccgg 157321 agtaatggag ggttttcttg tggttctaag cataagacac ccgccattta tgtatgatat 157381 aataataatt gtaaacgaat acacaaaagg gtgaggttcg atgataagag aagatgaagt 157441 aagaaaacta gtcggagaaa tgcgcgaacc ttttcttcaa agacctctgg gagaattgga 157501 tgccgttaag gaaattaaaa taaagcctga aaaacggcat atcagtgtaa aagtcgctct 157561 tgcaaaaaca ggaactgcag aacaaatgca gattcagcaa gagatcgtaa acgtattaaa 157621 aggggcagga gctgagacag tcggccttcg atttgaagag ctgcctgaag aaacggttgc 157681 taaattccgg gcgccgtcag ctgagaaaaa aacattatta aatatggata acccgccagt 157741 ctttcttgct gtagcaagtg gaaaaggcgg cgtaggcaag tcaactgtgt cagtaaacct 157801 agctatttct ctggctcgtc tagggaaaaa ggttggttta attgatgcgg atatttatgg 157861 gttcagtgtg ccggacatga tgggtatcac tgtgcgtcca acaattgaag gagagaaact 157921 tcttcctgtt gaacgctttg gagtaaaggt catgtcaatg ggctttttcg tagaagaaaa 157981 tgccccggtc gtatggagag ggccgatgct cggcaaaatg ctgaataatt ttttccatga 158041 agtagagtgg ggagaagtag actatatcgt tcttgatctt ccgcctggta caggggacgt 158101 tgctctcgat gtacatacaa tgcttccgag ctgcaaagaa attatcgtat ctacgccaca 158161 tccgacagct gcttttgtcg cggccagagc gggctctatg gcgattaaaa ccgatcatga 158221 ggtcgtgggt gtcatagaga acatggctta ttatgaaagt gcaaagacag gggaaagaga 158281 atatgtgttt ggaaaaggcg gaggagataa actggctgag gaactaaacg tgcctttgct 158341 cggcagaatc ccattgaaac agcccgattg ggataaggac caatttgctc cgtctgttta 158401 tgacgaaaat catccaatcg gagaaatata tcaggacatc gcaaaaaaaa tagatgcaaa 158461 aatgtcagtg caggtataaa aggtgaaccg ggattccaga tcccggcttt ccctttattc 158521 actttctttt gctgtgtctt ttgctgcttt tttcagctca tcttcgaact gctttttgta 158581 aagcggacta gaaagtgttt cgttaataac ctcttctaaa taactgcgga attcttggct 158641 ttttgccagc tggctgtact ttttatccat gccgggatcc tgcataacgc tcatcagcat 158701 cttctggtaa tctggatcct tcatcagctt tttaatcact ttttcatgct ctgtctgaag 158761 agttttggca aagccctcag caaaatcagt gtcttcaaag atgtttttcc aaaattcttc 158821 acctttttta gatgtgagtg ttttttctat tgttccttta attgcatctt ggtcaatcac 158881 cagcgcttca ttcatggcat catcatttaa taattcctta atagctttct ttccatcatc 158941 agtttttaat atatcaacaa ccattttttt ggtctgatca tagtccatat ccgctgcttg 159001 gtcttttgga gcgcaagctg ttacagataa taacaaaaaa cagctcatca atagcgtttt 159061 ggcttttgac atgcttaagc tcctttcaca tacttgtctt acctttaata tgattcatct 159121 gtttggaatt atacataaca aaatatcgct gttcgcgatt tttgagggga tgaataaaga 159181 aatgaaaagc cgtggtttag ttcgtttttt cttttctatt ttagctgtcg gggcgcttat 159241 cacgagtatt gtgggttttg ctttaaagtg gggagaatat agagggctgt ttctaacatt 159301 tgaagcggga cagattttct ctgttttatt ttggtttatc ggtgtaggca tgattttcag 159361 tgtgatcagc caaatgggtt ttttcgtgtt tttaacagtt catcggtttg cgcttgagat 159421 attaaggtcc tcctctttgt ggaatttgct gcagttgttt ttcatcctgt ttgttgcttt 159481 tgatttaatg tacgtgcgtt ttttattttt tggagagagc ggagaatcgc tggctggcta 159541 tgcgtggtta ccggtgtttt tattgatctt tggagtgatt acagcttata taaagcaaaa 159601 gcagtcctct aagaaaacat ttgtgtcatc gttatttttg atggttgtga ttaccgcatt 159661 agaatggttc cctgcattaa gagtaaatga tgaggactgg ctttatttaa tgctttttcc 159721 gttaatggca tgtaatgcct tccaattgct gatgctgccg aagtttgcag caaagtaatt 159781 actttacctc tgcggatttg gcatcagaat ttgcgatgag atcacccacg gttacatttt 159841 ttaatccttt ttctttcagc tgatggatga tatcaggcaa tgcttcttct gtttgttttg 159901 cagaatcgga ggcatgtaaa agaataatgt ctccaccgga aacttgcttg gtcacattgt 159961 cgatgatttt ttcaactccg ggatttgtcc agtcttgaga gttcacactg taatgaacga 160021 ctgtataatt gtattgcttt gcgaccttta gaacattctt attgaattgg ccggtagggg 160081 gtcttaatag ctgtatgtct ttgaccccta acttttcaaa ggctgtttgc gcacggttca 160141 tgtccttttt tatttcgctg ctctctaaat tggcatagtt tttataagcg tagcccatgc 160201 tcccgatttg atggccgtcc tttacgatac gggccactgt gtcgggatgg cgttctgccc 160261 aagaagcgga caggaaaaac gttgcgtttt taatcccgtt tgctttcaga gtattaagta 160321 tcggttctgc tctctcatca ccccagctga tatcgaaagt aagtgaaata tctttagagt 160381 ctgtttctcc tttataaatg gctttaggtc cggtgtcagt tgaaaacacg ggaagcggga 160441 cagctctttg gatataaaaa aagctggcag ctgcaaatgc ggcgataagt ataataatta 160501 attgttttac ccgtttaatg tgccacacat agaagtgatt cactgatgat gcctccttat 160561 cttgtccatc attcttgttt tacatcttat gagcatggac aattgaatat aaccgataaa 160621 atgtctcttc acatacagcc taaattgggt gttgaccttt tgataatatc cgtgatatat 160681 tattattcgt cgctgataaa cagctgacat caactaaaag cttcattaaa tactttgaaa 160741 aaagttgttg acttaaaaga agctaaatgt tatagtaata aagctgcttc gttaagcggc 160801 agtaatgatc tttgaaaact aaacaagaca aaacgtacct gttaattcat ttttataaat 160861 cgcacagcga tgtgcgtagt cagtcaaact actttatcgg agagtttgat cctggctcag 160921 gacgaacgct ggcggcgtgc ctaatacatg caagtcgagc ggacagatgg gagcttgctc 160981 cctgatgtta gcggcggacg ggtgagtaac acgtgggtaa cctgcctgta agactgggat 161041 aactccggga aaccggggct aataccggat ggttgtttga accgcatggt tcaaacataa 161101 aaggtggctt cggctaccac ttacagatgg acccgcggcg cattagctag ttggtgaggt 161161 aatggctcac caaggcaacg atgcgtagcc gacctgagag ggtgatcggc cacactggga 161221 ctgagacacg gcccagactc tacgggaggc agcagtaggg aatcttccgc aatggacgaa 161281 agtctgacgg agcaacgccg cgtgagtgat gaaggttttc ggatcgtaaa gctctgttgt 161341 tagggaagaa caagtaccgt tcgaataggg cggtaccttg acggtaccta accagaaagc 161401 cacggctaac tacgtgccag cagccgcggt aatacgtagg tggcaagctt tgtccggaat 161461 tattgggcgt aaagggctcg caggcggttt cttaagtctg atgtgaaagc ccccggctca 161521 accggggagg gtcattggaa actggggaac ttgagtgcag aagaggagag tggaattcca 161581 cgtgtagcgg tgaaatgcgt agagatgtgg aggaacacca gtggcgaagg cgactctctg 161641 gtctgtaact gacgctgagg agcgaaaacg tggggagcga acaggattag ataccctggt 161701 agtccacgcc gtaaacgatg agtgctaagt gttagggggt ttccgcccct tagtgctgca 161761 gctaacgcat taagcactcc gcctggggag tacggtcgca agactgaaac tcaaaggaat 161821 tgacgggggc ccgcacaagc ggtggagcat gtggtttaat tcgaagcaac gcgaagaacc 161881 ttaccaggtc ttgacatcct ctgacaatcc tagagatagg acgtcccctt cgggggcaga 161941 gtgacaggtg gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt taagtcccgc 162001 aacgagcgca acccttgatc ttagttgcca gcattcagtt gggcactcta aggtgactgc 162061 cggtgacaaa ccggaggaag gtggggatga cgtcaaatca tcatgcccct tatgacctgg 162121 gctacacacg tgctacaatg gacagaacaa agggcagcga aaccgcgagg ttaagccaat 162181 cccacaaatc tgttctcagt tcggatcgca gtctgcaact cgactgcgtg aagctggaat 162241 cgctagtaat cgcggatcag catgccgcgg tgaatacgtt cccgggcctt gtacacaccg 162301 cccgtcacac cacgagagtt tgtaacaccc gaagtcggtg aggtaacctt ttaggagcca 162361 gccgccgaag gtgggacaga tgattggggt gaagtcgtaa caaggtagcc gtatcggaag 162421 gtgcggctgg atcacctcct ttctaaggat attatacgga atataagacc ttgggtctta 162481 taaacagaac gttccctgtc ttgtttagtt ttgaaggatc attccttcga aacgtgttct 162541 ttgaaaacta gataacagta gacatcacat tcaagtaata caagatatca catagtgatt 162601 ctttttaacg gttaagttag aaagggcgca cggtggatgc cttggcacta ggagccgatg 162661 aaggacggga cgaacaccga tatgcttcgg ggagctgtaa gcaagctttg atccggagat 162721 ttccgaatgg ggaaacccac cactcgtaat ggagtggtat ccatatctga attcatagga 162781 tatgagaagg cagacccggg gaactgaaac atctaagtac ccggaggaag agaaagcaaa 162841 tgcgattccc tgagtagcgg cgagcgaaac gggattagcc caaaccaaga ggcttgcctc 162901 tggggttgta ggacactctg tacggagtta caaaggaacg aggtagatga agaggtctgg 162961 aaaggcccgc cataggaggt aacagccctg tagtcaaaac ttcgttctct cctgagtgga 163021 tcctgagtac ggcggaacac gtgaaattcc gtcggaatcc gggaggacca tctcccaagg 163081 ctaaatactc cctagtgacc gatagtgaac cagtaccgtg agggaaaggt gaaaagcacc 163141 ccggaagggg agtgaaagag atcctgaaac cgtgtgccta caagtagtca gagcccgtta 163201 acgggtgatg gcgtgccttt tgtagaatga accggcgagt tacgatctcg tgcaaggtta 163261 agcagaagat gcggagccgc agcgaaagcg agtctgaata gggcgcatga gtacgtggtc 163321 gtagacccga aaccaggtga tctacccatg tccagggtga agttcaggta acactgaatg 163381 gaggcccgaa cccacgcacg ttgaaaagtg cggggatgag gtgtgggtag gggtgaaatg 163441 ccaatcgagc ctggagatag ctggttctct ccgaaatagc tttagggcta gcctcaaggt 163501 aagagtcttg gaggtagagc actgattgga ctaggggccc ctaccgggtt accgaattca 163561 gtcaaactcc gaatgccaat gacttatcct tgggagtcag actgcgagtg ataagatccg 163621 tagtcgaaag ggaaacagcc cagaccgcca gctaaggtcc caaagtatac gttaagtgga 163681 aaaggatgtg gagttgctta gacaaccagg atgttggctt agaagcagcc accatttaaa 163741 gagtgcgtaa tagctcactg gtcgagtgac tctgcgccga aaatgtaccg gggctaaacg 163801 tatcaccgaa gctgcggact gttcttcgaa cagtggtagg agagcgttct aagggctgtg 163861 aagccagacc ggaaggactg gtggagcgct tagaagtgag aatgccggta tgagtagcga 163921 aagaggggtg agaatcccct ccaccgaatg cctaaggttt cctgaggaag gctcgtccgc 163981 tcagggttag tcgggaccta agccgaggcc gaaaggcgta ggcgatggac aacaggttga 164041 tattcctgta ccacctcctc accatttgag caatgggggg acgcaggagg atagggtaag 164101 cgcggtattg gatatccgcg tccaagcagt taggctggga aataggcaaa tccgtttccc 164161 ataaggctga gctgtgatgg cgagcgaaat atagtagcga agttcctgat tccacactgc 164221 caagaaaagc ctctagcgag gtgagaggtg cccgtaccgc aaaccgacac aggtaggcga 164281 ggagagaatc ctaaggtgat cgagagaact ctcgttaagg aactcggcaa aatgaccccg 164341 taacttcggg agaaggggtg ctctgttagg gtgcaagccc gagagagccg cagtgaatag 164401 gcccaggcga ctgtttagca aaaacacagg tctctgcgaa gccgtaaggc gaagtatagg 164461 ggctgacgcc tgcccggtgc tggaaggtta agaggagcgc ttagcgtaag cgaaggtgcg 164521 aattgaagcc ccagtaaacg gcggccgtaa ctataacggt cctaaggtag cgaaattcct 164581 tgtcgggtaa gttccgaccc gcacgaaagg cgcaacgatc tgggcactgt ctcaacgaga 164641 gactcggtga aattatagta cctgtgaaga tgcaggttac ccgcgacagg acggaaagac 164701 cccgtggagc tttactgcag cctgatattg aatgttggta cagcttgtac aggataggta 164761 ggagccttgg aaaccggagc gccagcttcg gtggaggcat cggtgggata ctaccctggc 164821 tgtattgacc ttctaacccg ccgcccttat cgggcgggga gacagtttca ggtgggcagt 164881 ttgactgggg cggtcgcctc ctaaaggtaa cggaggcgcc caaaggttcc ctcagaatgg 164941 ttggaaatca ttcgcagagt gtaaaggcac aagggagctt gactgcgaga cctacaagtc 165001 gagcagggac gaaagtcggg cttagtgatc cggtggttcc gcatggaagg gccatcgctc 165061 aacggataaa agctaccccg gggataacag gcttatctcc cccaagagtc cacatcgacg 165121 gggaggtttg gcacctcgat gtcggctcat cgcatcctgg ggctgtagtc ggtcccaagg 165181 gttgggctgt tcgcccatta aagcggtacg cgagctgggt tcagaacgtc gtgagacagt 165241 tcggtcccta tccgtcgcgg gcgcaggaaa tttgagagga gctgtcctta gtacgagagg 165301 accgggatgg acgcaccgct ggtgtaccag ttgttctgcc aagggcatcg ctgggtagct 165361 atgtgcggac gggataagtg ctgaaagcat ctaagcatga agcccccctc aagatgagat 165421 ttcccattcc gcaaggaagt aagatccctg aaagatgatc aggttgatag gtctgaggtg 165481 gaagtgtggc gacacatgga gctgacagat actaatcgat cgaggactta accatatttt 165541 tgaatgatgt cacatctgtt atctagtttt gagagaacac tctcaatttg tttggtggcg 165601 atagcgaaga ggtcacaccc gttcccatac cgaacacgga agttaagctc ttcagcgccg 165661 atggtagtcg ggggtttccc cctgtgagag taggacgccg ccaagcagat ttattaattc 165721 taccatgttt gtttatgaag ctttatatct cattccgcag tagctcagtg gtagagctat 165781 cggctgttaa ccgatcggtc gtaggttcga atcctacctg cggagcattg cttccatagc 165841 tcagcaggta gagcacttcc atggtaagga agaggtcagc ggttcgagcc cgcttggaag 165901 cttaaatgta ttattaccaa ggtttctcat aaggagaaag ctttttttat tgcgatatgc 165961 ggaagtagtt cagtggtaga acaccacctt gccaaggtgg gggtcgcggg ttcgaatccc 166021 gtcttccgct ccatttacct aacgggatat tgtaaattga attgcgcccg tagctcaatt 166081 ggatagagcg tttgactacg gatcaaaagg ttaggggttc gactcctctc gggcgcgcca 166141 tatcttttaa tagaatagat aggaaatcgg gaagtagctc agcttggtag agcacatggt 166201 ttgggaccat ggggtcgcag gttcgaatcc tgtcttcccg accatttttt atggggcctt 166261 agctcagctg ggagagcgcc tgctttgcac gcaggaggtc agcggttcga tcccgctagg 166321 ctccaccaaa agtttttaaa aaaggttatt gactttgaag aagtgacatt gtatactaat 166381 aaagttgctt taacaaagcg gacaaacaaa atgatctttg aaaactaaac aagacaaaac 166441 gtacctgtta attcagtttt taaaaatcgc acagcgatgt gcgtagtcag tcaaactact 166501 ttatcggaga gtttgatcct ggctcaggac gaacgctggc ggcgtgccta atacatgcaa 166561 gtcgagcgga cagatgggag cttgctccct gatgttagcg gcggacgggt gagtaacacg 166621 tgggtaacct gcctgtaaga ctgggataac tccgggaaac cggggctaat accggatggt 166681 tgtttgaacc gcatggttca aacctaaaag gtggcttcgg ctaccactta cagatggacc 166741 cgcggcgcat tagctagttg gtgaggtaac ggctcaccaa ggcaacgatg cgtagccgac 166801 ctgagagggt gatccggcca cactgggact gagacacggc ccagactcta cgggaggcag 166861 cagtagggaa tcttccgcaa tggacgaaag tctgacggag caacgccgcg tgagtgatga 166921 aggttttcgg atcgtaaagc tctgttgtta gggaagaaca agtaccgttc gaatagggcg 166981 gtaccttgac ggtacctaac cagaaagcca cggctaacta cgtgccagca gccgcggtaa 167041 tacgtaggtg gcaagcgttg tccggaatta ttgggcgtaa agggctcgca ggcggtttct 167101 taagtctgat gtgaaagccc ccggctcaac cggggagggt cattggaaac tggggaactt 167161 gagtgcagaa gaggagagtg gaattccacg tgtagcggtg aaatgcgtag agatgtggag 167221 gaacaccagt ggcgaaggcg actctctggt ctgtaactga cgctgaggag cgaaagcgtg 167281 gggagcgaac aggattagat accctggtag tccacgccgt aaacgatgag tgctaagtgt 167341 tagggggttt ccgcccctta gtgctgcagc taacgcatta agcactccgc ctggggagta 167401 cggtcgcaag actgaaactc aaaggaattg acgggggccc gcacaagcgg tggagcatgt 167461 ggtttaattc gaagcaacgc gaagaacctt accaggtctt gacatcctct gacaatccta 167521 gagataggac gtccccttcg ggggcagagt gacaggtggt gcatggttgt cgtcagctcg 167581 tgtcgtgaga tgttgggtta agtcccgcaa cgagcgcaac ccttgatctt agttgccagc 167641 attcagttgg gcactctaag gtgactgccg gtgacaaacc ggaggaaggt ggggatgacg 167701 tcaaatcatc atgcccctta tgacctgggc tacacacgtg ctacaatgga cagaacaaag 167761 ggcagcgaaa ccgcgaggtt aagccaatcc cacaaatctg ttctcagttc ggatcgcagt 167821 ctgcaactcg actgcgtgaa gctggaatcg ctagtaatcg cggatcagca tgccgcggtg 167881 aatacgttcc cgggccttgt acacaccgcc cgtcacacca cgagagtttg taacacccga 167941 agtcggtgag gtaacctttt aggagccagc cgccgaaggt gggacagatg attggggtga 168001 agtcgtaaca aggtagccgt atcggaaggt gcggctggat cacctccttt ctaaggatat 168061 tatacggaat ataagacctt gggtcttata aacagaacgt tccctgtctt gtttagtttt 168121 gaaggatcat tccttcgaaa cgtgttcttt gaaaactaga taacagtaga catcacattc 168181 aagtaataca agatatcaca tagtgattct ttttaacggt taagttagaa agggcgcacg 168241 gtggatgcct tggcactagg agccgatgaa ggacgggacg aacaccgata tgcttcgggg 168301 agctgtaagc aagctttgat ccggagattt ccgaatgggg aaacccacca ctcgtaatgg 168361 agtggtatcc atatctgaat tcataggata tgagaaggca gacccgggga actgaaacat 168421 ctaagtaccc ggaggaagag aaagcaaatg cgattccctg agtagcggcg agcgaaacgg 168481 gattagccca aaccaagagg cttgcctctt ggggttgtag gacactctgt acggagttac 168541 aaaggaacga ggtagatgaa gaggtctgga aaggcccgcc ataggaggta acagccctgt 168601 agtcaaaact tcgttctctc ctgagtggat cctgagtacg gcggaacacg tgaaattccg 168661 tcggaatccg ggaggaccat ctcccaaggc taaatactcc ctagtgaccg atagtgaacc 168721 agtaccgtga gggaaaggtg aaaagcaccc cggaagggga gtgaaagaga tcctgaaacc 168781 gtgtgcctac aagtagtcag agcccgttaa cgggtgatgg cgtgcctttt gtagaatgaa 168841 ccggcgagtt acgatctcgt gcaaggttaa gcagaagatg cggagccgca gcgaaagcga 168901 gtctgaatag ggcgcatgag tacgtggtcg tagacccgaa accaggtgat ctacccatgt 168961 ccagggtgaa gttcaggtaa cactgaatgg aggcccgaac ccacgcacgt tgaaaagtgc 169021 ggggatgagg tgtgggtagg ggtgaaatgc caatcgaacc tggagatagc tggttctctc 169081 cgaaatagct ttagggctag cctcaaggta agagtcttgg aggtagagca ctgattggac 169141 taggggcccc taccgggtta ccgaattcag tcaaactccg aatgccaatg acttatcctt 169201 gggagtcaga ctgcgagtga taagatccgt agtcgaaagg gaaacagccc agaccgccag 169261 ctaaggtccc aaagtatacg ttaagtggaa aaggatgtgg agttgcttag acaaccagga 169321 tgttggctta gaagcagcca ccatttaaag agtgcgtaat agctcactgg tcgagtgact 169381 ctggcccgaa aatgtaccgg ggctaaacgt atcaccgaag ctgcggactg ttcttcgaac 169441 agtggtagga gagcgttcta agggctgtga agccagaccg gaaggactgg tggagcgctt 169501 agaagtgaga atgccggtat gagtagcgaa agaggggtga gaatcccctc caccgaatgc 169561 ctaaggtttc ctgaggaagg ctcgtccgct cagggttagt cgggacctaa gccgaggccg 169621 aaaggcgtag gcgatggaca acaggttgat attcctgtac cacctcctca ccatttgagc 169681 aatgggggga cgcaggagga tagggtaagc gcggtattgg atatccgcgt ccaagcagtt 169741 aggctgggaa ataggcaaat ccgtttccca taaggctgag ctgtgatggc gagcgaaata 169801 tagtagcgaa gttcctgatt ccacactgcc aagaaaagct ctagcgaggt gagaggtgcc 169861 cgtaccgcaa accgacacag gtaggcgagg agagaatcct aaggtgatcg agagaactct 169921 cgttaaggaa ctcggcaaaa tgaccccgta acttcgggag aaggggtgcc ctgttagggt 169981 gcaacccgag agaaccgcag tgaataggcc ccaggcgact gtttagcaaa acacaggtct 170041 ctgcgaagcc gtaaggcgaa gtatagggct gacgcctgcc cggtgctgga aggttaagag 170101 gagcgcttag cgtaagcgaa ggtgcgaatt gaagccccag taaacggcgg ccgtaactat 170161 aacggtccta aggtagcgaa attccttgtc gggtaagttc cgacccgcac gaaaggcgca 170221 acgatctggg cactgtctca acgagagact cggtgaaatt atagtacctg tgaagatgca 170281 ggttacccgc gacaggacgg aaagaccccg tggagcttta ctgcagcctg atattgaatg 170341 ttggtacagc ttgtacagga taggtaggag ccttggaaac cggagcgcca cttcggtgga 170401 ggcatcggtg ggatactacc ctggctgtat tgaccttcta acccgccgcc cttatcgggc 170461 ggggagacag tgtcaggtgg gcagtttgac tggggcggtc gcctcctaaa aggtaacgga 170521 ggcgcccaaa ggttccctca gaatggttgg aaatcattcg cagagtgtaa aggcacaagg 170581 gagcttgact gcgagaccta caagtcgagc agggacgaaa gtcgggctta gtgatccggt 170641 ggttccgcat ggaagggcca tcgctcaacg gataaaagct accccgggga taacaggctt 170701 atctccccca agagtccaca tcgacgggga ggtttggcac ctcgatgtcg gctcatcgca 170761 tcctggggct gtagtcggtc ccaagggttg ggctgttcgc ccattaaagc ggtacgcgag 170821 ctgggttcag aacgtcgtga gacagttcgg tccctatccg tcgcgggcgc aggaaatttg 170881 agaggagctg tccttagtac gagaggaccg ggatggacgc accgctggtg taccagttgt 170941 tctgccaagg gcatcgctgg gtagctatgt gcggacggga taagtgctga aagcatctaa 171001 gcatgaagcc cccctcaaga tgagatttcc cattccgcaa ggaagtaaga tccctgaaag 171061 atgatcaggt tgataggtct gaggtggaag tgtggcgaca catggagctg acagatacta 171121 atcgatcgag gacttaacca tatttttgaa tgatgtcaca cctgttatct agttttgaga 171181 gaacactctc aatttgtttg gtggcgatag cgaagaggtc acacccgttc ccataccgaa 171241 cacggaagtt aagctcttca gcgccgatgg tagtcggggg tttccccctg tgagagtagg 171301 acgccgccaa gcaattgcac attagtgtaa ttttttaaaa aagttattga ctttgaagaa 171361 gtgacattgt atactaataa agttgcttta acaaagcgga caaacaaaat gatctttgaa 171421 aactaaacaa gacaaaacgt acctgttaat tcagttttta aaaatcgcac agcgatgtgc 171481 gtagtcagtc aaactacttt atcggagagt ttgatcctgg ctcaggacga acgctggcgg 171541 cgtgcctaat acatgcaagt cgagcggaca gatgggagct tgctccctga tgttagcggc 171601 ggacgggtga gtaacacgtg ggtaacctgc ctgtaagact gggataactc cgggaaaccg 171661 gggctaatac cggatggtta gtttgaaccg catggttcaa acataaaagg tggcttcggc 171721 taccacttac agatggaccc gcggcgcatt agctagttgg tgaggtaacg gctcaccaag 171781 gcaacgatgc gtagccgacc tgagagggtg atcggccaca ctgggactga gacacggccc 171841 agactcctac gggaggcagc agtagggaat cttccgcaat ggacgaaagt ctgacggagc 171901 aacgccgcgt gagtgatgaa ggttttcgga tcgtaaagct ctgttgttag ggaagaacaa 171961 gtaccgttcg aatagggcgg taccttgacg gtacctaacc agaaagccac ggctaactac 172021 gtgccagcag ccgcggtaat acgtaggtgg caagcgttgt ccggaattat tgggcgtaaa 172081 gggctcgcag gcggtttctt aagtctgatg tgaaagcccc cggctcaacc ggggagggtc 172141 attggaaact ggggaacttg agtgcagaag aggagagtgg aattccacgt gtagcggtga 172201 aatgcgtaga gatgtggagg aacaccagtg gcgaaggcga ctctctggtc tgtaactgac 172261 gctgaggagc gaaagcgtgg ggagcgaaca ggattagata ccctggtagt ccacgccgta 172321 aacgatgagt gctaagtgtt agggggtttc cgccccttag tgctgcagct aacgcattaa 172381 gcactccgcc tggggagtac ggtcgcaaga ctgaaactca aaggaattga cgggggcccg 172441 cacaagcggt ggagcatgtg gtttaattcg aagcaacgcg aagaacctta ccaggtcttg 172501 acatcctctg acaatcctag agataggact gtcttcgggg gcagagtgac aggtggtgca 172561 tggttgtcgt cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga gcgcaaccct 172621 tgatcttagt tgccagcatt cagttgggca ctctaaggtg actgccggtg acaaaccgga 172681 ggaaggtggg gatgacgtca aatcatcatg ccccttatga cctgggctac acacgtgcta 172741 caatggacag aacaaagggc agcgaaaccg cgaggttaag ccaatcccac aaatctgttc 172801 tcagttcgga tcgcagtctg caactcgact gcgtgaagct ggaatcgcta gtaatcgcgg 172861 atcagcatgc cgcggtgaat acgttcccgg gccttgtaca caccgcccgt cacaccacga 172921 gagtttgtaa cacccgaagt cggtgaggta accttttagg agccagccgc cgaagtggga 172981 cagatgattg gggtgaagtc gtaacaaggt agccgtatcg gaaggtgcgg ctggatcacc 173041 tcctttctaa ggatattata cggaatataa gaccttgggt cttataaaca gaacgttccc 173101 tgtcttgttt agttttgaag gatcattcct tcgaaacgtg ttctttgaaa actagataac 173161 agtagacatc acattcaagt aatacaagat atcacatagt gattcttttt aacggttaag 173221 ttagaaaggg cgcacggtgg atgccttggc actaggagcc gatgaaggac gggacgaaca 173281 ccgatatgct tcggggagct gtaagcaagc tttgatccgg agatttccga atggggaaac 173341 ccaccactcg taatggagtg gtatccatat ctgaattcat aggatatgag aaggcagacc 173401 cggggaactg aaacatctaa gtacccggag gaagagaaag caaatgcgat tccctgagta 173461 gcggcgagcg aaacgggatt agcccaaacc aagaggcttg cctcttgggg ttgtaggaca 173521 ctctgtacgg agttacaaag gaacgaggta gatgaagagg tctggaaagg cccgccatag 173581 gaggtaacag ccctgtagtc aaaacttcgt tctctcctga gtggatcctg agtacggcgg 173641 aacacgtgaa attccgtcgg aatccgggag gaccatctcc caaggctaaa tactccctag 173701 tgaccgatag tgaaccagta ccgtgaggga aaggtgaaaa gcaccccgga aggggagtga 173761 aagagatcct gaaaccgtgt gcctacaagt agtcagagcc cgttaacggg tgatggcgtg 173821 ccttttgtag aatgaaccgg cgagttacga tctcgtgcaa ggttaagcag aagatgcgga 173881 gccgcagcga aagcgagtct gaatagggcg catgagtacg tggtcgtaga cccgaaacca 173941 ggtgatctac ccatgtccag ggtgaagttc aggtaacact gaatggaggc ccgaacccac 174001 gcacgttgaa aagtgcgggg atgaggtgtg ggtaggggtg aaatgccaat cgaacctgga 174061 gatagctggt tctctccgaa atagctttag ggctagcctc aaggtaagag tcttggaggt 174121 agagcactga ttggactagg ggcccctacc gggttaccga attcagtcaa actccgaatg 174181 ccaatgactt atccttggga gtcagactgc gagtgataag atccgtagtc gaaagggaaa 174241 cagcccagac cgccagctaa ggtcccaaag tatacgttaa gtggaaaagg atgtggagtt 174301 gcttagacaa ccaggatgtt ggcttagaag cagccaccat ttaaagagtg cgtaatagct 174361 cactggtcga gtgactctgc gccgaaaatg taccggggct aaacgtatca ccgaagctgc 174421 ggactgttct tcgaacagtg gtaggagagc gttctaaggg ctgtgaagcc agaccggaag 174481 gactggtgga gcgcttagaa gtgagaatgc cggtatgagt agcgaaagag gggtgagaat 174541 cccctccacc gaatgcctaa ggtttcctga ggaaggctcg tccgctcagg gttagtcggg 174601 acctaagccg aggccgaaag gcgtaggcga tggacaacag gttgatattc ctgtaccacc 174661 tcctcaccat ttgagcaatg gggggacgca ggaggatagg gtaagcgcgg tattggatat 174721 ccgcgtccaa gcagttaggc tgggaaatag ggaaatccgt ttcccataag gctgagctgt 174781 gatggcgagc gaaatatagt agcgaagttc ctgattccac actgccaaga aaagcctcta 174841 gcgaggtgag aggtgcccgt accgcaaacc gacacaggta ggcgaggaga gaatcctaag 174901 gtgatcgaga gaactctcgt taaggaactc ggcaaaatga ccccgtaact tcgggagaag 174961 gggtgctctg ttagggtgca agcccgagag agccgcagtg aataggccca ggcgactgtt 175021 tagcaaaaac acaggtctct gcgaagccgt aaggcgaagt ataggggctg acgcctgccc 175081 ggtgctggaa ggttaagagg agcgcttagc gtaagcgaag gtgcgaattg aagccccagt 175141 aaacggcggc cgtaactata acggtcctaa ggtagcgaaa ttccttgtcg ggtaagttcc 175201 gacccgcacg aaaggcgcaa cgatctgggc actgtctcaa cgagagactc ggtgaaatta 175261 tagtacctgt gaagatgcag gttacccgcg acaggacgga aagaccccgt ggagctttac 175321 tgcagcctga tattgaatgt tggtacagct tgtacaggat aggtaggagc cttggaaacc 175381 ggagcgccag cttcggtgga ggcatcggtg ggatactacc ctggctgtat tgaccttcta 175441 acccgccgcc cttatcgggc ggggagacag tgtcaggtgg gcagtttgac tggggcggtc 175501 gcctcctaaa aggtaacgga ggcgcccaaa ggttccctca gaatggttgg aaatcattcg 175561 cagagtgtaa aggcacaagg gagcttgact gcgagaccta caagtcgagc agggacgaaa 175621 gtcgggctta gtgatccggt ggttccgcat ggaagggcca tcgctcaacg gataaaagct 175681 accccgggga taacaggctt atctccccca agagtccaca tcgacgggga ggtttggcac 175741 ctcgatgtcg gctcatcgca tcctggggct gtagtcggtc ccaagggttg ggctgttcgc 175801 ccattaaagc ggtacgcgag ctgggttcag aacgtcgtga gacagttcgg tccctatccg 175861 tcgcgggcgc aggaaatttg agaggagctg tccttagtac gagaggaccg ggatggacgc 175921 accgctggtg taccagttgt tctgccaagg gcatcgctgg gtagctatgt gcggacggga 175981 taagtgctga aagcatctaa gcatgaagcc cccctcaaga tgagatttcc cattccgcaa 176041 ggaagtaaga tccctgaaag atgatcaggt tgataggtct gaggtggaag tgtggcgaca 176101 catggagctg acagatacta atcgatcgag gacttaacca tatttttgaa tgatgtcaca 176161 cctgttatct agttttgaga gaacactctc aatttgtttg gtggcgatag cgaagaggtc 176221 acacccgttc ccataccgaa cacggaagtt aagctcttca gcgccgatgg tagtcggggg 176281 tttccccctg tgagagtagg acgccgccaa gcaagcttaa acccagctca ttgagctggg 176341 ttttttgttt tatatctgtg ccgatttgct ttcgtcagta tccattttat caagcttctg 176401 ctttttaaag ttttctaata cttttgaatt ccaatacaat ccctagcatg atcaacatga 176461 gagtcataaa taatcaaaat gcagtttgta cgggagactc atccagactc catccgactg 176521 cgattggcag gatagagccg ccaatccatt ggcagcgaac agcatgcttg tcgtttgttc 176581 tgtttttcca tgataaaatt gattggtgac aataaaataa tggcgaacat gccggccata 176641 aataagtcct aagaaaaaac taagaataat ccctgcaaaa gctgttttat tgattgccaa 176701 aatacagagt taaatgaggc cgctcatatt tatcagcctg agataatgat gataggttat 176761 tttttcggaa accagctcgg gttgccaaat gagagaaaag atattactgt cattaaaacg 176821 attcttggtt tcatccggat atgataaaat gtctcagact atatttgagc catttttttc 176881 ttcagcaatc atcttgcgta attgataaaa atttattatg atactctttg tatgacaact 176941 ccttgcctca atacaatata ctcaacgttt ccccgttttc tccggtcgtt tttcttttca 177001 ttttctcccg taaaataaaa aaagctccca atacaataga tatggtgcgg atttattttt 177061 tactaaaaag gagtcgttat atttgaataa tagttttaca ttaaaacagc aatggttcgg 177121 gaatatccga aaagacattc ttgctggcat tttagttgcg ttagcgttaa tacctgaagc 177181 gattggcttt tctattatag ccggtgtgga tccgatggtc ggtctttatg cgtcattttg 177241 catagccatt attatttcta tttttggtgg cagacctggc atgatttcag ctgcgacagg 177301 ctcaatggca gtcgttatgg tgtcgctggt tgctgatcat gggcttcagt atttatttgc 177361 ggctacgatt ttgacaggca ttattcaggt gattttaggt atcagtaaaa ttgcaagatt 177421 aatgaaattc atcccgcgtt ctgtgatgat cgggtttgtg aatgcgctgg cgatccttat 177481 cttctctgcg cagcttcccc agtttgaagg tgcttcttgg agcatgtatg cgatgcttgc 177541 cgggtcgttg gttattattt atgtgctgcc aaggtttacg actgctgttc cgtctccgct 177601 tgtggcgatt attgtgatga caattattgc ggtcactttc catgtggatg tgcggacggt 177661 tggtgatatg ggcaatattt ctagttcatt gcctcatttc ttaatccctg atgttccgtt 177721 tacctttgaa acactgcaaa ttatttttcc ttattcaatt gctttagcgt ttgtcgggtt 177781 gcttgaatct ttgctgacag cacagattat tgatgaaatg acggatacgg atagtgataa 177841 aaataaagag agccgcggac agggaattgc gaatatcgtg actggattct ttggcggaat 177901 ggcaggctgc gctatgatcg gacaatctgt cattaataca aaagcgggcg gtcgcggacg 177961 tttgtcagca tttgttgccg gtgcttttct gatgttttta attgcggtgt taagtcatgt 178021 cgtggtgaaa atcccaatgg cggcgttagt agctgtaatg gttatggtgt ctgtcggcac 178081 ttttgattgg tcttctttaa aaggtctcaa aaaagcgccg ctcacggact cgattgtcat 178141 ggttgtgact gtggttacgg ttgttgtgac ggatgactta tctaagggtg tatttgtcgg 178201 tgttctttta agtgccgtgt tctttgtagc aaaaatctcg aagctgaaaa tcgtttctca 178261 tgcagaggat caaaagctta gaacgtatca agtgaagggg caaatctttt ttgcgtcagt 178321 gactgatctt acgaatgcgt ttatatatca agaggatatt gagcgggttg tgattgactt 178381 aactgaagct cacgtatggg acgattctgg tgcggccgca cttgataaga ttgttgcgaa 178441 gtttaaggaa caaggcattg aagctgagtt aaaaggtttg aataaagcga gtaaatctct 178501 aatgaaacag atggcataaa atagagaagc ccagatgaat gagatctggg cttttttata 178561 taacatacac ttaagcagca ttgatataat agagagaaga gaaattttaa ataggggact 178621 tgcatatgat gcttcagaag ctgaaccgtg tattggggag agtgatgccg ctgttaacgc 178681 cgactagtgt ggtgctgggc gtgctgctgt ctcagttttt aaatgggtat gaatgggctg 178741 tgccttggat ctttgctttt attacgtttg caggcagttt gagcgcgaac tttcaatctt 178801 tgagacatgc attgtctcat cctctcccta tgattcttgc actattcgtt cttcatattt 178861 tcatgccgct ttttgcttgg ggcagcggcc atcttatatt taaaggtgat cctttgacga 178921 ttaccggttt aacattggct gttgtgattc ctacggggat tacaagcttg atttgggcag 178981 cgatgtacaa agggaatgtc ggtttgacac tttcgattat tttagttgat actgtgctgt 179041 caccgctaat cgtaccgctg agtctttcat tgctggccgg cgctcaggtt cacatggatg 179101 tgtggggaat gatgaaaggt ctgattgtaa tggtcgtgat tccttctttt ttgggcatgc 179161 tgtttaatca gatgtcatct ccagaaagaa ctgcgtttgt gagcagtgcg ctgtcgcctt 179221 tttcaaagct ttgcttgatg gcagtgattg cgattaacag ttcagcgatt gctccttatt 179281 tcaaatccat tgatttgaga tttgcaggaa tagctgtaac ggtattcttt atcgcgttaa 179341 caggttatgc cgctgcttgg ctgatcggaa aaatgatgaa aaggcggcaa gaggaaatag 179401 tctctcttat atttacggga ggcatgagga atattagtgc cggcgcagtt cttgccgtta 179461 cgttcttccc gtctcaggtt gccgttcctg ttgtgatcgg catgctgttt cagcagatat 179521 tggctgcttt gtttggctat atgctgaatc gttttgaatt aaaaccaatg ttgcagaagg 179581 cataaaaaaa ccgctcatag ggttgagcgg ttttttccgt atagccattc gagcgcgttg 179641 atgaactgtt tgcagaaata cttgtggtgg tgcaccgctc ctttttcaat tgaaagacac 179701 aactggtctt cagtgaagcc tttttctttt agactttgat gaacttgctt tgtttttttc 179761 agcatatgtc gctgaatgga ttgtttttca cggccttctt cactcccgat agacatgaaa 179821 acacgtgcag tgccgggctt taaagaagat atatgaatgg tttccgctgc gttctcgtac 179881 cagtatgaac ctgatataga gcctattttc ccgaacattg acggatattt taatatggcg 179941 aacattgaga tgaggccgcc taatgaggca ccgatcattc ctcttgactg cggttccctg 180001 gtgacgttcc agttttcttc gattagcgga atgaactggt tcgttatatc agacagatag 180061 tgatatccca ttccgccgaa gtccgtgaac cgatcactga gtgatgcagc cggccatggg 180121 gtgtattcat caagccggtt ttcgggttcg ataccgatca gcacgagttc agggagcctt 180181 tgctgttgaa aggcgctttc tagtaattcg atttggtttt ggaacaaaga actgccatcc 180241 tgcacgtaaa cagcaggaaa tcccccgctg tctgtgctgt aggaaggagg gaggtacagc 180301 gtgaacctcc tgttgccggc tttgtgttct gaaagagatc ctttcaagca ttctccccct 180361 ttttttgctt gaaaagcaga tataagaaat aaggaactcc gaggatcgcc aaaatgatgc 180421 ctgcgggcac ttctgcgggc tgaaaaaaca gttttccggc aaagtctgcg cttatcacaa 180481 gaagcatccc gattaaaccg ctcagtggca ggatatagcg atgttcgacg ccagccagtc 180541 tccgtgagat atggggagca attaagccga caaacgccat acttcccgct acggagacac 180601 aggcgctgat gattgctaca caggcaacga gaaggatggt tttttcttta tttgatgaaa 180661 taccgaggct tctgactgtg tcttcatcaa aacgaatggt gtcgagcagg cgggatttgc 180721 cgataagaat cggtataaac agcagcatcc atgggagtac agctgtaata tacgtccagt 180781 tggcagacca gatgcttccg tttttccaca ccatggccat ttgatagtct tgcgggtcca 180841 tttttaaaga taaaaacaaa gacagggcgc tgaatcctga attgatcgca atccctacca 180901 aaataattct tcctgaatct aaattgcctc tgtgccatgc aaatatgtaa atcaggatcg 180961 ccgcgatgag cccgcctatc aatccaaaga gcggcattcc catcgctgca gctatggatg 181021 tcacttcctt ctggccttgg aataagagca taaacgctac aatgccagct cctgcccctg 181081 cgttgattcc gagaattcca gggtcagcaa gcccgtttct cgtgatggcc tggataacag 181141 cgcctgcaat gccaagaccg agtccaataa tagcagccat gacaacccgc ggcagtctta 181201 aatcgaacag caaaatttca tactgcggat tcgggtcgat ttgaaaaaga gtggagagca 181261 gctcagcagg acgaacagaa aatgatccgc tcgttaagct gaaatagctg acaacaagaa 181321 tcaaagcgat gaacaatgca tattttttag ccattttgct cccctccttt tcgtttaatt 181381 aaataaagga agaaaggtac gccgataatg gatgttacga cctcaatcgg tgtttcaaac 181441 ggatagttga taaatctgct tgcgagatca cacagggtta aaaagattcc gcccaaaata 181501 caggaacacg gaatcagcct gctgtaatca gagccgacga gaaatctcgt gatatgcgga 181561 acaaccaacc cgacaaacgc aatttttccg gccagcgcta cggcactgcc ggttagaatg 181621 atgacggaaa gcatcgccat gattttaatg gtttttttct tttgccccag gcttttagaa 181681 atgtcgtccc ctaatgatac agcggttacc tttttgctga gagaaatggc cattataatg 181741 ccaatcagga aaaacggagc ggcaagcttc aggaaatctg gactcatttg atgaagtctg 181801 gcactgtacc agaaactgag atcctgagaa atttgaaaat aaatcgacat ggccgctgat 181861 aagctgctga gcagcatgct tgtgactgtg ccgatgatgg cgagctgcac gggggtaaat 181921 ccgtttggca tcatggcggc aaggccgaat actaacaccg ctcctaacgc tgagccgata 181981 aaagagtata tcatcatttc aatcgaagat gattgcggga gcagaaccat gcaaagcgta 182041 atgataaacg ctgaaccatc tgaaacaccc ataatggatg gcgaagctaa ataattgcgc 182101 gtaatgccct gcataagcgc tccagaaaca gcaagggctg cccctatgag cagagcgccg 182161 gcagcccttg gaatccggga atgccatata atttgatggt ctgtgtttcc cggatcgaaa 182221 tgaataagag atgtaaaaac aatatctgtg ctgagatgct ttgccccata aaggattgaa 182281 agcaaaagtg acagcgctat agcaaatgga gaagtaatca atatgatacg tgtccactgt 182341 tttgaataca tacaaaaacc tactctgaat tagttttgtg tcaatttttc agcagccgct 182401 ttcaggaaac ggactttgct ccaagctgtg ccgccttgtg cgagagggtc cactgagttg 182461 acatacacat ggtcttcttt gactgcttta aggcttttcc agattggatt tttctctaaa 182521 tcttttaagg catcaggttt gtctgcattt tcatcatcag aaaattggac gaaaatatgg 182581 tccgggttca tttcacttaa tttttctaat gaactcagct cttgcgcttt tgcagccttt 182641 acttcgttcg gcgccttaag gcctaaatca ccgtatagtg tggagttgaa atacacctgt 182701 tcagggtaaa tgtaaatgtt gccttgtctg attctgatga caagcgcttt tgaatctttc 182761 gctttatcgt tgatttttgt ttttatttct tttagatcct gttcatagtc tgcaataatt 182821 ttctttgctt ttttctcttt tccagtcagc tgggcaagaa gcatcatgtt ttccttccag 182881 tttgaagaga tatgagaaac tgggatcgtc gtgcctgctg tgctgatttt ttgcagcgtt 182941 ttttccggaa actttgttga agcaaggata acatctggct tcatttcaag aatcttttca 183001 atatttggct ccattttttc tccggttggt tcggctttat cagtgatgtc tttgaacata 183061 tcagggaatt tgccggagaa tgaaattgcg ccttgcggat gaacgtcaag caatttcgcg 183121 tcttccattg attcaacgct tcccgtaatg gcaattttgt ctgtcggtac agttacttca 183181 tatgttttat caaggtattc aattttcttc ttctcagatg ctgtgccgct tgccttgctg 183241 gcagttgatt catttttgct gccgcaagct gccgccgtca gcgcgagaag taagattaat 183301 aaggtaagag atatcttttt catctataga gcctcctgtt caattgataa ctattatcaa 183361 ttggaattat agagaatgaa cagatataac accatggaca aattcctgat ttatcatgga 183421 caatctccgg atagtaaaga aacagtttgc tgaacgatgc gttcgtgccc gcaagctgag 183481 tattcattcc acgggtcaag ggatagaaga taaacacggt tatctcgtac cgcgcttagg 183541 ttttgccatg cttctgtctg ctgtaattgc tggtagtaag ctatggtctc cggctcttta 183601 aaaagaaaaa gcatcataca gtcagcttgg taatttgcga tattttctaa cgaaatcgct 183661 tgttctgaag gtgtgtcagc cgttgttgcc gagctgaatc ctaaatcccc aaagaaaact 183721 tcgcggacac ttcggttatg agccagatag aagttttgct tatgcagcct caaaaagaga 183781 aaacgcagcc cttgaacgtg ctgaagtgtt tttttggcgg ccgttgtctg ctggtcataa 183841 tccgctagcc acttttctgc ttcggactcc tcctttaaaa atgaggcagt ttgcagaaag 183901 tgggttctcc agctttcttc tgaaggaagg tacatgactt ctgcgatgcg attcaggcga 183961 tcttgttctt ctggagaaat agaatccatg ctgacaatca catctggttc tgcctgtgat 184021 aacgtgtaca ggttttcttc ccacttttca ttaaaccggt atgcactgag ctggacgggt 184081 atatctgtcg aataatgctg atagtagtaa gacgtccatt tcggatgcag agcggccgca 184141 aaaggtatgt ggtgaagagg gatgagatgg cccattgtgc cccttccgta tgcggcgatt 184201 ttctttcggc gttttttcat atagcttgta ggtgaacagc ctgtatattt tttaaagatt 184261 ctgctgaaat aaaattcatc ttgataaccg gtttggtgtg cgatttcttt caatttgcag 184321 tttgattttg ccatgagccg ttttgccttt gtgattcgtg ttttcgtaat aaattctgtt 184381 acgctctgtc ctgtccattt tttaaagctt tcactgtagt gtttggcact gattcctgcc 184441 atttgcgaca gctgggcaag cgtgattttt gtatcggcat gggtttcgat atagtgtttt 184501 gttttttcga ttgctgaatg tgtatccgtt tgatcagata aactggcagt aaaaagatca 184561 taaatcaggc tttgtacttc aatcacacat tttagctgag aaagctgaga cgattcattc 184621 catagtgcgg caagctcttg aagccggact gcaagatttt cgatatgtga aacattcata 184681 agcttcagtt tggctaattc cgattctgtg cacggtgtga aaatatcttg cccggtttcc 184741 ttgatatagc ttagaagcct gattatacag gcatctatat gtccatcggc tgctggcgta 184801 aagccaaagg tctcgttagg cggacaaaca taaagtgtct ttttttgcag aggattggtg 184861 tttgttccga tcgaaatata gccgtttcct tttaaatgaa aaatcagcac gaatgaatcg 184921 gctaattgct gttctgagaa gagatcactt gtctttttta gatattcaat ttgtactggt 184981 tgataaatca ctgcattttg cacgagtaga ccaccttttc agaagctttc aattgataat 185041 cattttcaat aaaaattgta ccaaataaat gaaagttttc ctatataaag cgggtgggtt 185101 tttagcatga aaaaaaccct tacttatgtg taaaagtaag ggtctttcgt tcaataagaa 185161 tatgttacac gtgtaacata cgatgcttat gttctaataa atgagatact tttttcttgt 185221 tttgctgaat tgttggagtg ttttttcata gctgtttatg atgttctcaa ccgaagttcc 185281 attttcaatt tttgtcctga tccagccgtt gcctgccagt ttatcgaatg aacctgttga 185341 caggaactca aaatcctcag gatagagatc gtgtatggtt ttaatgactg aaagacccgt 185401 tttaacggct tcaaacttat ctctgtctgt cacatagagc tgcacaccgt ggcaaagcgt 185461 tccttgatgt ttagaaaacg tcggtgtgaa ggatgctgcc ctaaatgtaa cgcccggcaa 185521 atggaggctg tttaatgttt cttcaagttc tgtgcttttg ataaagggag ctccgatcaa 185581 ttcgaatggc tttgttgtcc ctcgcccttc ggatatattt gttccttcaa tcagcccggt 185641 tgcaggataa acaaatgtgc tttccaccgt cggcatgtta ggcgaaggga ggacgaaagg 185701 caatcgggta tcgtcaaaat ccatttttcg tttccagtgt ttcattttta ccactgtaag 185761 atcggcatca atactaaatt ctttgttgaa cagtgaagcc aattcgccta tcgtcatccc 185821 atgcttcaat ggaatgggat acaatccgac aaatgaggcg tattcaggtt ctaagattgg 185881 tccttcaata tgattcccgc cttgaggatt cggacggtcc agcaccataa atggaatgcc 185941 gttttcttta gcggcttcca ttgcgtatgc cattgtataa atgtacgtgt agaaacgggt 186001 cccgacatcc tgaatgtcaa acattagaat atcgacattt ttaagcattt ctggagtcgg 186061 ttttttcgtt tttccgtaga ggctgtatac gggaaccccg gttttttcgt caatgtaaga 186121 gcctacttcg tctccagcct gggcgtcacc gcggacgccg tgttcagggc cgaataaagc 186181 tgtcagtttg atatccgggt tctcgtaaag gatatcgaca ctgcttttta gagatgtgtt 186241 tactccggct ggattggtga tcagtccgat gcgttttccc ttgagctgtt ttttatagtc 186301 tggcaagagc gtgtctatcc cagtctggac tttaggtttt ttagctgttt gattctttga 186361 atcgggtgaa gcagaggcag cggttatcgt tccgaacatc atgagccctg tcagaaaagc 186421 gaatattgtt tttctcatgt gtccctcctt attaaagcgg tcttcccgtt ttgatattta 186481 atccgtagcc aagtgggtaa agggtgttcc ctggtttcgt gactgacgga atgtcaactg 186541 gaagtgtgcc tttaggtttt gcctggccga atatcgccat cactccggcc ggaatattag 186601 gttgaagata acggccattt gcgtatcctt taaagccata gactgcaatc agtgcttttg 186661 cttcttcgaa attggctgcg tcataggggt tgcgcaggct cattaagaca aatggtttgt 186721 tgtgctgcag tgcggctttc atgacagctc tcggaaacac ggtggcccat ttgcttgaat 186781 ctgatattgt gtcgtcgatg acaccgtcgt tgacgacagg gtcatttttg acgacatagg 186841 agccggtaat gatataatca gcctctttta cttgtttttc atgctcggtc ttaaatactt 186901 ggctggcaaa gttcattttg ctgagggata cgggtttgat tttctttcgc ttgatgagat 186961 cgtgaatggt ttgttcgatt gaagcagttt gttcttcgta aggtgccaca attaagattc 187021 ggctgccttt tttaggcttg aacggcaaag tgtgctgttc attttttaat acagttactg 187081 ctttttcagc taattttttc tctgctttca ggtgctgctt gcttcctacg atttttttgg 187141 ctttggctat tttttctttt gtactgtcgc tgtttcgcgc tggatacatg ccgcgtttta 187201 ttttcaggga aatgattctt tcaactgaat tgttgatttg ttgttcagga atatccccgt 187261 ttttcacggc ttctttcaaa gcttgaataa cacgtgcgaa tttctgttct tctttcaatg 187321 aagtgactga ggctggcatt aatgcaatat cgacaccagc ttttacggcc atgaccacag 187381 cctcttcctg tccgaaatga tctgcgattg ccttcatatt gagcgcatcg gtaacgatga 187441 ccccattaaa gcccatttcc tgacgaagaa gacctgtcat cacttttttt gaaagtgtag 187501 ctggaaccag aatgtccgat ccatcgagtt tgcttttgta agtggtgtca tcaaaggcgg 187561 gaaactgaac atgggctgtc atcaccatat cagcaccagc atcaattgct ttttgaaaag 187621 gataaagctc gacctcacga agccgttctt ggccatggga aacgagcggc agtccataat 187681 ggctgtcaac gtccgtgtct ccatgtcccg ggaaatgttt gagggcagac gcgatatcct 187741 gccgctgcaa ccctttcatc gtatataaac cgaggcgtga tgtcagttct cgattggagc 187801 tgaatgaccg tacgccgatt acaggattat caggattatt gttaatgtcc acgacagggc 187861 tgaaatctgt attgatgcct aaggcagaga gctcttttcc gatgatgctg ccggtctgat 187921 acgcattgat tctgcttctg gctgcgccca gcgccatatt ccctgggaaa ttagtgccct 187981 cccctaacct cgttacaatg ccgccttcct gatcaatact cagcatgagc gggatttttg 188041 gacttgcctt ttggtaatcg tctgtcagtt ggacagtttg ttttgttgtt tttacatttt 188101 ctgcaaaaag gatgatgcct ccgaattgat atttcttgac gaggctggcg acttcatcat 188161 tcatttttgt aagggcttgc ggagaggact cgccttcctt ttgccaattt ctaaaatcag 188221 gcatcagcat ctggccgagt ttttcatcta acgacatacg attgacaatc tgattggcat 188281 cgattgcacg tttggatgca gaggcttctg tctgtctggc cccgaaaaag catgaaagaa 188341 agagaacggc tgaaaggata agcggaaaga caggtctcat agaaacttcc tcctatcgtc 188401 taatcattca ctccatcgct tcataaatcg cggttatgac acttccataa ctgcctgttg 188461 gaaattggtc accttcaaag acgttcggat tttcttccgg atcaataact ggtgtatgct 188521 ttttatttgt taacaatgcg atgcctaaat tgtatgctgg atcaataatt gtaactgtcc 188581 ccgtccagcc ggtatgcccg taagcatttt cgctggcatg agggccaaac atccattcca 188641 tgcttttact tccgttccgc ctccagccaa gagcgaatgt cggatctgtt gctgaaggtg 188701 ctgtaaacag gtcggctgtt ttctgatcaa ataaagaaat gtttcggtat gaacctttgt 188761 ttaacatgac ttgcagcagt atggccatat catctgcatt tgagaacaat ccggcatgcc 188821 cagacacgcc gtccattgag taaaacgctt tttcgtcatg cacctctcct tgcagcgtgt 188881 ttgtgcggat gttagggaat tgaataacgc cgtcacgtgt attgcccatg cgttcagtag 188941 ctgcgaactg tttcggttta aagccctttt gcagcggatt gtacaaggta tgcttcagcc 189001 tgagcggttt gtagagctct tgctccgtgt agacatcaag cggtttgccg gtgagttttt 189061 cgacaataca tccgagtagc atatatccaa tgtcactgta tacgtgtttt gtcccggttt 189121 gataatcgag cggaattttc gtcaaatatt caatcgtttt gtcccgttct tgggaatagt 189181 acttgccggc tttttccggc gtgtaaaagt aaaagcttga tgggagccct gattggtgct 189241 ggaggacatc aatgacacgt atcttgtctt ttccttttat gaggtcaccc ggctgatcct 189301 tgaaacccgg caaatatgca gaaacttttt catagacgtc aagttttcct tggctgacta 189361 agcgctgcaa tgcaaaattt gttgcgtaca tttttgtatt tgaggctaag tcaaacatcg 189421 tgcgggtttt cattttggcc ggacggcgca gcagttctga tccttcgtac tttttactgt 189481 agccgtatgc tgcttttttt atgatgcgtc catccttcac caccacaaga acggcgcctg 189541 gaaatcctgc tgcaatatcc cgttctatca tctgatctac cttccttagc ttcttcgtcg 189601 agaattgtgc agtttctgca tttatgattt tcggctcaat caagttgcct gctgtttgtg 189661 cgaaggtttc atttggcgca aatatcgata gggttaaaat ggcactgaat atgaacagtg 189721 tctttgtttt cacaggctag cccctttctg tgcttctatc ccgtttacta tccctaaaac 189781 agaaacaatt taatcgaact gagaagccat ttcatcttta tatccgaatg cataggtcaa 189841 taaaaaaccg gccgcgtagg aaataaagag cccaacgata tacaggatga tttgcgaagg 189901 caggactaga aaagatagcg gcagtccgga gacaccaatc gcaatggtgg ctacttgaaa 189961 ataagcttga aaggcgccgc cgattccagc tcctaaacat gctgttaaaa acggacggcc 190021 aagcggcagc gtgactccga aaataagcgg ttcaccaatg ccgagcagtc ccgatggaag 190081 cccgccggcg attgctttcc tcagtgttgt ttttttcgtc ttcacgaaaa cggcaaaggc 190141 cgcgcctacc tgtcctgcac ctcccatagc caaaataggg agcagaggat cattgccaat 190201 tgaattgatc agttccatgt gcacaggcgt caagccttga tgcagtccgg ttacgacgag 190261 aggaaggaag gttgcgccca gaataaagcc cgcagcgatg ccgccgatgt ccaggatgga 190321 cagtaggccg gatgtaatag catcagaaat gaatccgcct aaaggcataa atacgacata 190381 cgttacgatt ccggtgatta acagtgaaac ggtgggtgtg acaatgatat caagtgattg 190441 aggaataaaa cggcgaataa attgttcggt gtaagcaatg aatatggctg cgaaaaggac 190501 gccgatcaga cctcccctgc ccgggagaag ctcttctcca aataaactga tttttgcgat 190561 ctccggattg ataatcaaga tcccggccaa agccccaagt gcgggtgtcc cgccaaattc 190621 tttcgaagcg ttaataccga cgagaatgcc gagataagtg aacagccctg atccgatgac 190681 tgtcaggata atcgcaattt gtgagtctgc agagagccag cctgcttgaa taattgcttt 190741 ggtaatccca gtaattaaac cggaagcgac tagagcggga ataagaggga taaaaatgct 190801 ggcaatttta cgtaagaaaa gtttaaaagg agtggcattt ttccgattga tatcggcttt 190861 ctttttggcc gctgcttctt tgacatcggc accttcttct gctgacacga gctttgagaa 190921 agcagctgta acatgattga caactcctgt gccgaggata atttgtaagg tttcagcttc 190981 aacgaccccc aatacgccgt caagctttct taaagcctga gcatccgctt tgctttcatc 191041 gtaaggcgta atgcgcaggc gtgtcatgca atgcgtatat gaagaaatat tggattttcc 191101 tccgcatagc tcaaggattt tctgtgcgag atgatggtag ttattttctt tgctcattaa 191161 aacccctccc cttcaagatg ccttatttta ttctcataga ttgtatggct gctctcgttt 191221 tatctatata accggttgtc gtttcatact gctcagccgc catgcctaaa aacaaaacat 191281 caattataaa aagctgggcg aggcgggaag aagtggctgc acttcgaatc aaggcttcat 191341 tggaatgggc tgtatacaaa gggacatcag ccagtgcgga gacggatgtc tgactgaatt 191401 gtgtgaggct gatcgttgtg atgccttttt ccttagccat ggcgaacagt tcaacgattt 191461 cctgtgtctc tcctgaaaac gaaatggcga atacgatgtc gtctttatct gcatttgcga 191521 ttaaagatgc cacaagatga gtgtctgtaa acgcggttgc ttgtttatga atgcgaagcc 191581 acttttgctg ggcgtccttg gcgacaatgc cggaagcccc gaggccgata aaatgcacgg 191641 tatgagcttt gagaagcaga gaaaccgctc gttcaagctc tttgtagtcc atcaggtctg 191701 aagtatcctg aatggcttga atggcattgc cggccgtttt ttcggaaatg gagggcagcg 191761 gctcgtgggg aacaatatcc cggtagccct gaaacgtagg ctttgccaga tcgcctgcta 191821 ctctcatttt taaatcttga aatcctttta aaccgagtga tttgcagagc ctgatgacgg 191881 cagcgtcact tgaattggct aaggcgctga tttcgttgac cgtgctttcg attgctttgt 191941 ggggatgggc taggatataa tctgcaagtt tgcgctcgga tggagggagc ttatgcttca 192001 ttgattggat gatcgctaaa ccgcctgtgg ccattctagt tctctcctta tcatggatgg 192061 taatgttcga ttgctttgtc aatgaaaccg tttgcttcat cgagtaatgt ctgtgcttgt 192121 ttctgatctg tgcttgtttt gagcatgacg attgctgttt tgacgtgatg atcggcttgt 192181 tccagagtgt atctggctgt gtcgtatgaa gcgtttgtaa ggctttggat gatgctgatg 192241 gcgcgttctt ttagtttttt gttgctgacg ttgacgtcta ccatcaagtt ttcgtaaacc 192301 ttgccgattt tgaccattac agcggtagat atcatgttta gaatcatttt atgagcggtt 192361 gcggctttca tacgtgttga tcctgtaatg gcctcaggtc cgacgacaac ctcaatgctg 192421 tgatccgcat ccttgctgat ggcggaattt tcattgcaag taagggcgat ggtgtgtgct 192481 ccgactttac gggcgtatct tagggcgcct gcggcgtagg gtgtgcggcc gcttgctgcg 192541 atggcaatga cggtgtcatt tgaagtgagc tgtatgtttc ttaaatcttc agctcctgct 192601 tcttcactgt cttcaatgcc ctctgctgcc tgtaaaaagg cttcggggcc tccagccatg 192661 attccgatga cctgatctgg gcttacgctg taggtgggag gacattcaac agcatccatg 192721 acgccgagtc tgccgcttgt gccggcgcct gtatatatga gccggcctcc attttgaaac 192781 gattcatatg cgcagtctac agctgttttg atgtcgggga gaacctcctg aacggctgca 192841 gcgactttca tatcttcgtt gttgatcatt ttaaggatgc cgagagtgtt tgctttgtgg 192901 atttcaactg tttgactatt gcgtgattcc gttgtaagac ggtgaaggtt taatggttct 192961 gacatgagga tgccccctgt tttaaaatga tatatctcaa tattcagtat attcatttct 193021 gttatgatat ttcaactatg tttttaaatt tttgaaattt tatttcactt aagactataa 193081 gaaatgatga aggatcaact gttctccaag cggcccgatt cttcgccgtc ctttatcaag 193141 gaacccgctt ttcatataaa ggtgttttgc gcgtatgttc agatgattga cggccaagat 193201 gatttcgtcg caccatggaa aatatccgct cacaaaagcg ggaagcaaaa gcatggcttt 193261 tttcgcatag ccttttccgt gatgcacagc ggttaaagac agggagctga gcagtaaagc 193321 aaatggattg ttagaatagg aagcaagcgt ttcttttgat gcatgtaaaa tgaaaaaacc 193381 gactggaagg tcgtctttta agatgacaac cgggtatcgg tcctgtatgc ccagagcctg 193441 agacagcacc tctttcggga gggaggtaaa gcgtttgtca tcgttggtga gcgtgaatga 193501 ttggagctcg ggcaagtgtt caggcttata gaaggataaa gaaatgtctt gagtcatggg 193561 gtggcctcct tacaatatgt cgttaagctc gttttccgaa atgacgcggt agcccgcttg 193621 ttttaacagt gcggcggtta ctccgctgcc ggtgattttt ttgccagaga atgtgccgtt 193681 atagataaaa ccgcttccgc aagatggact gttttctttt aatatgacgg cagaagcgtt 193741 gatttctttt gcgtaagcca atgttttcgc ggcgccttcc atatatagtt ctgtgacgtc 193801 ttctcctgaa gctgtcacga ttttcgctgt tccattgagg acatcctcgc cagtgcctcc 193861 tatgatttct gcgggttcgc gtggggtaga gaagccgccg agaagttcag ggcaagccat 193921 gactgctttc ttttcatcga ctagttttct gattttctcc gacgctgcgt gagagccgtt 193981 atatctgcat tcaatgcctc caaggcaaga actgactaga atcatattgg tttctcctct 194041 cttgctttgc ttgtctctat cataaaataa atggctttag ttgggaggct ttttcagtta 194101 aaaaaggagt taaaaagttt gaaaataaaa aatttaattt tcctctttac aaacaggggg 194161 tgacctgtat ataataactt ttgtcagctc gacgagaaca caacggcccg ttggtcaagc 194221 ggttaagaca ccgccctttc acggcggtaa cacgggttcg aatcccgtac gggtcaccat 194281 ttggaggatt agctcagctg ggagagcatc tgccttacaa gcagagggtc ggcggttcga 194341 gcccgtcatc ctccaccatc ttgccggtgt agctcaattg gtagagcaac tgacttgtaa 194401 tcagtaggtt gggggttcaa gtcctcttgc cggcactgtt ttttcaaaat tttatgtgga 194461 ggggtagcga agtggctaaa cgcggcggac tgtaaatccg ctccctcagg gttcggcagt 194521 tcgaatctgc ccccctccac cattattggg ctatagccaa gcggtaaggc aacggacttt 194581 gactccgtca tgcgttggtt cgaatccagc tagcccagtc acagacacct ttgatcaaaa 194641 ggtgtctttt ttcttttcgg aaaaatcatt ccaacttcta actgttcagt ctgtataata 194701 attttaaaaa tatgttaagg tagtttattc acgaattacc atctacaccc tgccaaaaat 194761 ttgataaact tattttataa aaaaattgaa accttttgaa acgaagctcg tatacataca 194821 gaccggtgaa ggcagaggtt agataaatat ggaaatgatg attaaaaaaa gaattaaaca 194881 agtcaaaaaa ggcgaccagg atgcatttgc ggacatcgta gatatttaca aagataaaat 194941 ttatcagctt tgctaccgta tgcttggcaa tgtgcatgag gcggaggata ttgcacagga 195001 agctttcatc agagcgtacg ttaatatcga cagttttgat attaaccgga aattttcaac 195061 ttggctttat cgaatcgcga ccaatttgac cattgaccgc attcgcaaaa agaagccgga 195121 ttattacctc gacgcagagg tggctggtac ggaaggcttg accatgtatt ctcaaatcgt 195181 cgcagatggt gttttgcctg aagatgcagt tgtatcgctg gagctctcaa acacgataca 195241 gcagaaaatt ttaaagcttc ctgacaaata cagaacagtc atcgtattaa agtatattga 195301 cgaactctca ttaattgaaa tcggggagat tctaaacatt cctgtgggga ctgtgaaaac 195361 gcggattcac agaggcagag aggctcttag aaaacaatta agggatcttt aagtggggtg 195421 atgaaatgag ctgtcctgaa caaattgtgc agcttatgca tatgcatctt gatggagata 195481 tccttccaaa agatgaacac gtattaaatg aacatctgga gacatgcgag aaatgcagaa 195541 agcattttta cgagatggag aaatccatag cgctcgtacg gagcacatcg catgtcgaag 195601 cccccgcgga ttttaccgct aatgtcatgg caaaattgcc taaggagaag aaaagagctt 195661 ctgtaaaaag atggttcaga acccatcccg ttatcgcagc tgctgcggta ttcatcattt 195721 tgatgggcgg gggttttttt aacagctggc ataatgacca caatttcagc gtgtccaagc 195781 agccgaatct tgtggttcat aaccatactg tgaccgtgcc agaaggtgag acggtcaaag 195841 gtgatgtcac tgtcaaaaac ggcaagctga ttattaaagg caaaatagac ggggatgtaa 195901 ccgtcgtaaa cggcgaaaag tatatggcct ctgctggaca agtcaccggt cagattgaag 195961 aaatcaatca gttattcgac tggacatggt acaagatgaa gtctgcgggg aaaagtgtac 196021 tcgatgcatt caatccgaac ggagaagagt aaagcgcgtt agccgctttg ctcttttttt 196081 gcgggctgag agggctggca catttcactt gctaaatcga aatgtggtat aatgggctcg 196141 ctatgtaaag tacatatgcg taacacgtaa aacacaaaat acgaaatgac tgaaatcttg 196201 gaggacgagg aaatggcttt tgaggatatc ccttttttgc agtacctcgg caatgccgtt 196261 gatattctcc ttgtttggta tgtgatatat aaattgatta tggtgatacg cggcacgaaa 196321 gcggttcagc tgttaaaagg aattgtagtc atcgtgcttg ttcgtatggc cagccaatat 196381 ttgggcctca gcacacttca atggctgatg gaccaagcga taacatgggg atttttagca 196441 attattatta tttttcagcc tgagctgaga agagcgcttg aacagctagg ccgcggccgc 196501 tttttttcga ggagcggcac gcctgttgaa gaagcgcagc agaaaacgat tgaggccatt 196561 acaaaagcaa tcaattatat ggcgaaacgc cgtataggcg ccctgctgac cattgagcgg 196621 gatactggaa tgggcgatta tattgagacc ggcataccac taaatgccaa agtcagctct 196681 gagctgctga tcaatatttt tattccaaac accccgcttc atgacggtgc ggtaattatg 196741 aaaaataatg aaattgccgc ggccgcctgt tatctgccgc tttctgagag cccgtttatt 196801 tcaaaagaac tgggcacgcg gcacagagca gctgtcggta tcagtgaagt aacagacagt 196861 ttgacgatta ttgtgtctga agagaccggc ggcgtcagtg tggcaaagaa cggcgacctt 196921 cacagagagc ttacagaaga agcgctgaaa gaaatgcttg aagccgagtt taagaaaaac 196981 accagagaca cttcttctaa ccgctggtat tggaggggca agaaaaatgg ataaattctt 197041 aaacaaccgc tgggctgtga aaattattgc tctgcttttc gcgctcttgc tttatgtggc 197101 ggttaacagc aaccaagcac cgactccaaa aaaaccgggt gaatctttct ttccgacatc 197161 aacaactgat gaagcaactc tgactgatat tccggttaaa gcgtattatg atgatgaaaa 197221 ttacgtcgtg acgggtgttc cgcaaacggt taatgtcacg ataaaaggct cgacaagcgc 197281 cgtgaaaaag gctcggcaga ccaaaaactt tgaaatatat gccgatatgg aacatttgaa 197341 aaccggcaca cataaggttg agcttaaggc caaaaacgtg tcggatgggc tgacaatctc 197401 aattaatccg tctgttacga cagtgaccat tcaggaacgg acgaccaaaa gttttcccgt 197461 agaagtggag tactacaaca aaagcaagat gaaaaaaggc tattctccgg agcagccgat 197521 tgtcagtccg aaaaatgtgc agattaccgg atcgaaaaat gtgatcgata atatttctct 197581 tgtaaaagct tcagtgaatt tggaaaacgc agatgaaacg attgaaaagg aagcgaaagt 197641 gactgtctat gataaagacg gaaacgcgct tcctgtcgac gtggagccct cggtcatcaa 197701 gattaccgtt ccggtgacaa gcccgagtaa aaaagtgccc tttaaaattg aacggacagg 197761 aagccttcct gacggtgtca gcatagcgaa tattgaatcc agccccagtg aggtaacggt 197821 ttacggctca caggatgtgt tggattctct tgaatttatt gacggcgtca gcctagattt 197881 aagtaaaatt aacaaggatt ccgatatcga ggcagatatt ccgcttcctg acggtgtcaa 197941 aaaaatctca ccgtcaaagg tgactttgca tatagaagtc gatagtgaag cggatcagaa 198001 gttcgagaat gtccctatca agactgtagg gctgagcagc tcacaaaaca ttgaatttct 198061 tgatcctgaa tcacaagcga tagatgtaac ggctaaaggc tctcccacga atataaataa 198121 actgaaaaaa tcagatattg aattgtatgt gaatgtttca gatttagagg acggggagca 198181 tagcgtgaag cttgaagtga acgggccaca gaatgtaact tggtccttgg ggcggaaaaa 198241 cgccaaaatc aagctgacgt ctaagaaaag caatacatca acgaatgata acagcagcaa 198301 tacatcaggg aaccaggaca cagataaaca aacaaatgat caaaagaaca atcagcaaga 198361 agatacaaag aacactgata aaaacaacaa cgatcaaaac caagacggaa ataaagatca 198421 aaaccaagat caggatgagg atgaatccac tgcgaattca caatcctcat cggaataaaa 198481 aaggagcgat tataaaatgg gcaagtattt tggaacagac ggtgtaagag gtgtcgccaa 198541 tagtgagctt acacctgagc tggcctttaa agtcggacgt ttcggcggtt atgtgctgac 198601 aaaagacaaa caacgtccaa aagtgctgat aggccgcgat acacgcatct ccggccatat 198661 gctggaggga gcccttgtcg ccggactttt atccattggc gcagaagtca tgcgcctggg 198721 tgtcatttct acaccaggtg tatcttattt gacaaaagcg atggatgcag aggcgggcgt 198781 catgatttcc gcttctcata acccagtgca ggataacggc atcaaattct ttgggggaga 198841 tggatttaag ctttctgatg aacaggaggc tgaaattgag cgcctgatgg acgaacctga 198901 ggataagctg ccaagacctg tcggagcaga ccttggactt gtaaacgatt attttgaagg 198961 cggacaaaaa tatctgcaat tcttaaaaca gacagctgat gaagatttca caggcattca 199021 tgtggcattg gactgtgcca atggcgcaac gtcatccttg gcgacacacc tgtttgctga 199081 tttagatgca gatgtttcta caatggggac ttccccgaac ggattaaaca ttaatgacgg 199141 cgtcggttcg actcatcccg aagcgctcag cgcgtttgtc aaagagaaaa acgcggatct 199201 cggtcttgcg ttcgacggtg acggcgaccg cctgattgct gtcgatgaaa aaggaaatat 199261 tgtagacggc gaccaaatca tgtacatatg ctcaaaacat ctgaaatcag agggccgttt 199321 aaaggatgat acagtggttt caaccgtgat gagcaacctc ggcttctata aggcgctcga 199381 aaaagaaggc atcaaaagcg tgcagacagc tgtcggcgac cgctacgtag tagaagcaat 199441 gaaaaaagac ggctacaacg tcggcggaga gcagtcagga catcttattt tccttgatta 199501 caacacgaca ggggacggat tattgtctgc tattatgctg atgaacactt taaaagcaac 199561 aggcaagccg ctgtcagagc ttgcagctga aatgcagaag ttcccgcagc tgttagtcaa 199621 tgtgagagtg actgataaat ataaagttga agaaaatgaa aaagtaaaag cagttatttc 199681 tgaagttgaa aaagaaatga acggcgacgg ccggattttg gtgcgccctt caggaactga 199741 accgctcgtc cgtgtcatgg ctgaagcgaa gacgaaagag ctgtgcgatg agtatgtcaa 199801 tcgcattgtt gaagtcgtcc ggtcagaaat gggattagag taacgaagtc tattatcaga 199861 gagtgaacaa gacaagcgag gtttacataa gataattgtg agacatacgg caaagttgct 199921 taaaaaacaa ttgaccgttt atgccacatg ttgtaaaatc aagcttgtct tgttcttatt 199981 ttctcaatag gaaaagaaga cgggattatt gctttaccta taattatagc gcccgaacta 200041 agcgcccgga aaaaggctta gttgacgagg atggaggtta tcgaattttc ggcggatgcc 200101 tcccggctga gtgtgcagat cacagccgta aggatttctt caaaccaagg gggtgactcc 200161 ttgaacaaag agaaatcaca tgatcttcca aaaaacatgt aggaggggac gattgaaagt 200221 ccccttgaaa tttgactttc ttcgtctcct tttacaatct taggaggaag aaaaatatgt 200281 gtggaatcgt aggttatatc ggtcagcttg atgcgaagga aattttatta aaagggttag 200341 agaagcttga gtatcgcggt tatgactctg ctggtattgc tgttgccaac gaacagggaa 200401 tccatgtgtt caaagaaaaa ggacgcattg cagatcttcg tgaagttgtg gatgccaatg 200461 tagaagcgaa agccggaatt gggcatactc gctgggcgac acacggcgaa ccaagctatc 200521 tgaacgctca cccgcatcaa agcgcactgg gccgctttac acttgttcac aacggcgtga 200581 tcgagaacta tgttcagctg aagcaagagt atttgcaaga tgtagagctc aaaagtgaca 200641 ccgatacaga agtagtcgtt caagtaatcg agcaattcgt caatggagga cttgagacag 200701 aagaagcgtt ccgcaaaaca cttacactgt taaaaggctc ttatgcaatt gctttattcg 200761 ataacgacaa cagagaaacg atttttgtag cgaaaaacaa aagccctcta ttagtaggtc 200821 ttggagatac attcaacgtc gtagcatctg atgcgatggc gatgcttcaa gtaaccaacg 200881 aatacgtaga gctgatggat aaagaaatgg ttatcgtcac tgatgaccaa gttgtcatca 200941 aaaaccttga tggtgacgtg attacacgtg cgtcttatat tgctgagctt gatgccagtg 201001 atatcgaaaa aggcacgtac cctcactaca tgttgaaaga aacggatgag cagcctgttg 201061 ttatgcgcaa aatcatccaa acgtatcaag atgaaaacgg caagctgtct gtgcctggcg 201121 atatcgctgc cgctgtagcg gaagcggacc gcatctatat cattggctgc ggaacaagct 201181 accatgcagg acttgtcggt aaacaatata ttgaaatgtg ggcaaacgtg ccggttgaag 201241 tgcatgtagc gagtgaattc tcctacaaca tgccgcttct gtctaagaaa ccgctcttca 201301 ttttcctttc tcaaagcgga gaaacagcag acagccgcgc ggtactcgtt caagtcaaag 201361 cgctcggaca caaagccctg acaatcacaa acgtacctgg atcaacgctt tctcgtgaag 201421 ctgactatac attgctgctt catgcaggcc ctgagatcgc tgttgcgtca acgaaagcat 201481 acactgcaca aatcgcagtt ctggcggttc ttgcttctgt ggctgctgac aaaaatggca 201541 tcaatatcgg atttgacctc gtcaaagaac tcggtatcgc tgcaaacgca atggaagctc 201601 tatgcgacca gaaagacgaa atggaaatga tcgctcgtga atacctgact gtatccagaa 201661 atgctttctt catcggacgc ggccttgact acttcgtatg tgtcgaaggc gcactgaagc 201721 tgaaagagat ttcttacatc caggcagaag gttttgccgg cggtgagcta aagcacggaa 201781 cgattgcctt gatcgaacaa ggaacaccag tattcgcact ggcaactcaa gagcatgtaa 201841 acctaagcat ccgcggaaac gtcaaagaag ttgctgctcg cggagcaaac acatgcatca 201901 tctcactgaa aggcctagac gatgcggatg acagattcgt attgccggaa gtaaacccag 201961 cgcttgctcc gttggtatct gttgttccat tgcagctgat cgcttactat gctgcactgc 202021 atcgcggctg tgatgtggat aaacctcgta accttgcgaa gagtgttact gtggagtaat 202081 aaatgtttaa cccctttgga taagattatc taaaggggtg tttttatgtc caaaagcgaa 202141 agaacgtcta cagtggaaaa atggattaaa gaagttgatg gtacaggacc cgactatcga 202201 tcgaccatgg ctatagattt aagatgtttc ctcattagat cggtcaatca ggttaaaagg 202261 cattaaaact tggagagaaa ctgcttttgc ctaactgagt tttctaatgt taatacagat 202321 ataagagagc agttcctcat taagatacgc ttttgatagc agttggaatt tagcatgcta 202381 gaaatccgaa aaccggagag cctattggaa tgataacgtg tttttttatt gacaattaat 202441 aaagggcaaa gaattctaga agtcgcactt acaatgtact tgtgggatta ggttttaaag 202501 ttcattcttt ttttattgag tacattccgg ttaaagttga aatgattcag taaaggacac 202561 gccataaata aaaggtagcg tatgattgcc attctttcca tggaaccgat atttctaaga 202621 tttcatcttt cgtaggcttt cggttcatat tacgtaatat ttttatcgaa tgaataagac 202681 ccacatcatc gattggaaaa gctgtcggga acctaaggca gcgcattaga acataattgg 202741 ctgtccaagg accgattcct cgtattttaa ttaagttttt ttcagcatct ttaaagttca 202801 ttttcattaa tttttccctc gataattctc cacttgccat taatctggct attccaatga 202861 tatattcact ttttttcacc gtcattttaa tatctgccag gtcggtaggg gttaaccgtg 202921 caattcgctc gtacggtggg aacacccaat actttttacc attccattca atagaatcgc 202981 caaatgcttc tacaaattgc ttctttaagg agtacgcgaa ggctaagtta atttgttgcc 203041 ctaaaactcc ccaacataaa gcttcaaata aatcgggaat gccgatcact cgcaacccat 203101 aaaattttcg ggcaggcatt ttaagtaatg gatctgcttt tgccatttca taaaatggag 203161 ttaaatcgtt atcaagatca aaccattcat gaatatattt tacaatctct tcccgtttcc 203221 actgctcaac aggtctagaa tcgtttagga attgaacaat catttgttta ttattgatta 203281 cgcttacctg cactaaggac cgaatttccc caatggctat aacttttgta atgatattgt 203341 tctctatttc atacatgcat tcattttttt ccctggttag gtagccaagg ttcgcattca 203401 tgtcgaaaat ttcaggtaat gtaatgacaa taacatcatt gacttcatgc catgtcactt 203461 tttcattctc cttatcttaa ataattataa gaaaactcac gctggttgaa attagtttat 203521 cacataatca tctttactca ttttgttatc ttgctattac attctaacca ccttattttt 203581 ttctatttat gaggttatag tgtagttatc aagaatgcta aacgggagta gataaaaatg 203641 gcccaagata taaaaaacgc gtgtcgaaaa tttaaattgg gattcaattc aaagaattag 203701 atgagcattg taaggagagg tgagataaat gccggatagt atcaataacg gacataaaga 203761 gagccatgat catagaattt cgaatgatgc agaaatgata acagatgaaa agtggcaagc 203821 aattataaat aatgatgcag cgtacaataa tcaatttttc tacgctgtta aatcgacagg 203881 gatattctgt aaaccatcct gtaaatctcg cgttccgaaa aaagaaaatg tatgtatctt 203941 tccaaacaca gaacaagctc tccgcgcaaa ttttcgccct tgtaaacgtt gcaagcccac 204001 taatgaaaaa atgcctgata gcgagtgggt tgatttaatt actgaataca ttgataaaaa 204061 tttcacagaa aaattaacgc tagaatcgtt agcagatatt tgtcatggga gtccgtatca 204121 tatgcatcga acatttaaaa aaattaaagg cattacgctg gttgagtata tacaacaagt 204181 tagagtacac gcggctaaaa agtatttgat tcagacaaat aaagcgattg gagatatcgc 204241 tatatgtgtg ggtatagcta acgcgcctta ttttattact ttatttaaaa agaaaactgg 204301 acagacacca gcacgatttc gtcaaatgag taaaatggag gaaacgtaca atggaaacaa 204361 ataaaccaac cctttattgg tctttactaa tgttcaagga ttggaatttt tatattgctt 204421 caactttaaa ggggcttgtg tttgtaggtt cacagaacaa accaatcgag gaattgttcg 204481 aatgggctag gaaacgcttt ccgggaagtc ttcttgttga agatgatgat aagcttgaac 204541 cctatgccgt tgaaatcact caatatctag aaggaaagcg gaaaaacttt actgttccag 204601 ttgagtacgc cggtacgcaa tttcagctag ccgtctggaa tgcactttgt gaaattcctt 204661 atggacagac gaaatcctat tccgacattg caaatgatat aaataaacca gcagctgttc 204721 gtgctgtagg tgcggctatt ggggctaatc cggtattaat tactgtaccg tgccatcgtg 204781 taataggaaa gaatggctca ttaactggct atcggggcgg atttgaaatg aagacactgc 204841 tcctcgatct ggaaaagcga gcttcatctg aaatggatgt tcctcattga aagtgaatca 204901 tctataatgg gttggattct tttagaggaa agtaaagacc agtttactga taaacttgac 204961 aacttttaaa atttagcata tcttatacgt aacttaataa tcgatgcaga tgtttatttt 205021 tccttttaaa atatgtaggc ctttagcatt cttttcatat ttcattttaa atattgatag 205081 gatgaaaaag tatcctaata aaaaaggaag agaacatgag tcgatttatt tgataatcag 205141 gactatatta aaggaaatga aaacatagca taaagtaaag accaataata aggtagctct 205201 tcaaaaaact tcgctgaagt tagttgaagt gaagccgaca attttcagga ttcaatgatc 205261 taacataatc attgaaattt tgaagttgtc ggcttttttg ttggaaaaaa atagagataa 205321 ataaaaattg aaataaataa tagacaaata tgatctgatt gaaaggtctt ttgaccaata 205381 atgagtttta aaaaagggag aatttagaat gttagtttcg ctgagtttgt catcattatt 205441 aacattattt tttattatgc ttatggcttc tgggattagt ggactattgt ttttacatcc 205501 gcgtgtaccc ttgagttttg ttcgcattca tattgggatc ttggctttac cacttttggt 205561 ttccttactg attcttgcca atagtggtgt gagtggaaat gttggccctt ggcacttaga 205621 ttccttagct tgtttaatga ctttctttgt tcttgcaatt ggattcatca ttcagcgttt 205681 ttctgtacgt tacttaatgg gggatcgatc ttatcgaaaa tattttacgc tttttacttt 205741 cacaacagga gctgcttcaa tgacatggtt aagtggtgat ctccgcttga tggttctatt 205801 ttggggagca actcttgttg gtttaacctt acttataagg ttaaacagtg cttggcaagt 205861 ggctagtgaa gcagccaaaa tttctggacg gttatttttg ttaagttggt tttctttgtt 205921 ttttgcgatg atgtggcttt ttcatgccac aggtcaatgg cagctatcat tggttgtaac 205981 aaatgaaagt ttagctgggc tgggagaatg ggagagaaca gggattcagc tattgattgt 206041 actggcggtg atcattcctg cagctcaatg gccgttccaa agatggttgg ttgagtctat 206101 tgttgctccc accccagttt ctgcaattat gcatgcaggt ttagtaaatg ctggaggaat 206161 aatactaact cgattttcac ctctatttca tggtggtatc gcttcgatta tcttacttct 206221 gcttgctagc atttctgtat tgattggaac tggaattagt ttagttcagg ttgattataa 206281 acgccagtta gtaggctcca cgattggaca aatggggttt atgctcattc agtgtgcatt 206341 aggcgcctat atagcagcca ttattcacct tattttacat ggtttattca aggctacgtt 206401 gtttctacag gctggttcag cagtagggcg tcatgaagta tcgactcgca ctaatgaaag 206461 aacatcctat ttatgggtca tggctggtcg gattttatcc ttagttatag gtgttgcttt 206521 ttggctcact gctcctggag acgggtatca cttaatcagt gcgctgatct tagggtggtc 206581 attgtccgtt tcttgggatc agcttgtcgc ttttggagag ggccgaattg gccggattgc 206641 cggtttaact gttttaggag gagcagccct cgtatatttt atcattcatc accttttcta 206701 taagtggctg catacaacca tttttcaaag tgttcaacct ccaatgtcag ctgtcatgat 206761 tgtcgtatgt ctcttactct ttggcagtgc tttaggtacg tgggttgctc gtcatcgttc 206821 ttccgttttt ttcgcggtac tctatctttg gttagtccga ttaggtgaag caaaaccaaa 206881 gtcagtagag agtcacccag actaccttaa acaatatatt tcataaggag ctaatctgag 206941 atgggcatta catccgtatt aacgaaagat aatgtaaaaa agatagatac agatattgat 207001 gttcaagaaa gggatcttaa cgttttcatt acatctgcca gccgagtgat tgcgccactt 207061 tggcctattt ctacatttgc tgcacgtaat ccgtggatgg gacttgaaaa ccaacctttt 207121 gatcaggttg caagttggtt gaaaaacact cgcgatgttg atatataccc tagtgcgtct 207181 atgatccgtt cagcaaagaa taaaggtgag attgatgaag attttgtgga aatggggctg 207241 cagcgttggc ttgattcaca ttcctatcac atcccacggg acgtagcaga gcgattttgt 207301 catgctgcat taaagttaga tcccctgcct tccgaccttt tatcatcaca tgagctggag 207361 aaattagtaa gtgaatgtag tggattggat catatcgaga atgtgtttat gcagccacta 207421 agttcgtata tagagaatca agatggtgaa aggctagtca atatactaga tcatcatgtc 207481 attaaatgga gtaaattata tcttgatgac tctcaagcgg gttggacaat gcctaatcgt 207541 gaggaaggtt tctatcgtgc ttggcagcat cttattcaat atgatccagc acttagcaaa 207601 aagcagcgag aaagggtaaa aggttggccg aaagaggcac atttggcttt acaagaagct 207661 ttattcgcac tagaaatccc agagtcagaa atccagactt atcttgaagg tcatttactt 207721 tcattacctg gatgggcagg gatgatgctt tggcgctccc aacaatcgag ccacgaacat 207781 gcactactaa cagaatattt agcggttcga atatccatgg agtgggctct tataaagcca 207841 tacttacctt tgactaatga acgatctaag aaaacaattt caattgctcc ccttatagca 207901 gcttggattc attggggtgg gcttacatta gaagaatggt cacagatgac ggccagtgaa 207961 caaaacgaat atttatcatt tgcctacagc tttgatgaga aacttcgcaa gaaactttgg 208021 ttagaagctt gggaacaaac gtacactgat cgattaagcc agaagatcat ctcgaaacaa 208081 cgtgaaaccg gccgtgaaaa atctgcatta gctcaattag cattctgcat cgatgtacga 208141 tcagaacctt ttcgtcgtca actagaaaaa gaaggcccgt ttgaaacgat tggtattgct 208201 ggtttcttcg gggtgccgat tgcaacttgt gaacttggca gtaaacacag tcatgcttcc 208261 ttgccgatca tacaaaaacc gcaaaataaa ataaaagagt tcgcagatga ggatgtattc 208321 aaaaaataca atcaacggaa gcaagcaatt cattctttaa gccatacctt taaaacgatg 208381 aagcagaatg cgctttcgag cttactactg cctgagctaa gtggaccttg gcttactctg 208441 caaatggcag cccgtagctt tgtgccaaga aaggcgggtc gtttcattcg taatctccgt 208501 gaggcttggt tacgcaaacc tgatacaaaa ctctcgcttc atcatgatgc tacagaggca 208561 gaaatacctg tgggttttac tgatgaagaa aaagtgaact atgctcgcca agcattaaaa 208621 atgatggggt taacagagaa catcgcacca ttggtcgtga tttgtgggca tggcagtcaa 208681 agtactaata atccttattc tgcagccctt gattgtggtg cctgtggtgg agcggccggt 208741 ggattcaatg caagagtttt agctgcttta tgtaatctat cagaggtacg agaagctctt 208801 ttagctgaag gaattaaaat tcctgaggat acagtttttg cagcagctga acataataca 208861 acagtagatg aattacattg gctttatgta ccagagcttt ccgaagctgc acaagaagca 208921 tttgaacaaa ttgaagccgt tatgccgaaa gtgagacatc atgtaaacgc agaacgtcta 208981 gcccaattac cgaatttcca atcgaagcta aaaaatccga aggctgaggc aaaccgattt 209041 gcggaagatt ggagtgagat acgtccggaa tggggactgg ctcgtaatgc cgcttttatt 209101 atcggtaaac gtgaattaac tcaggattgt gatttggaag gcagagcctt tctccataat 209161 tatgattgga agcaggatga aagcggtgaa ctcctagcaa atattattgt aggacctgga 209221 actgtagccc aatggattaa tttacaatat tacgcatcaa cggtagcacc tcattattat 209281 ggcagcggaa ataaagcaac tcaaaccgtt actgcaggtc tcggcgttat gcaggggaat 209341 gcaagcgatt tgttagccgg actgccttgg caatccgtca tggaatcaga tcacgaggcc 209401 tatcattctc ctcttcgttt attgatactc atccaagcac ctagagaata tgtagaacgg 209461 ttattaaatc atgattcagc atttctgcaa aaagttcaaa atggatgggt ccgactggct 209521 agtcttgatc cagaaggatg ttgggaaagc tggtaatgat gaatctaagc atttatcaaa 209581 tggatttgtt actcaataca aaaatgataa acataaggaa gaggtgtgct gtatgaatgt 209641 aaaccaaaat aaaaaagtat tatttttgac ggatattgaa aacggtttgg agcctatttt 209701 acaagaagcg actaacactt ctgcagagaa tatgttgact atacaaagct atggtgccag 209761 tatttcacat ccttatggag aaatcatgag gtctgttatt tttgcgattt accaggaaga 209821 tgttgaggag atttttgtag taggaacaaa agataagaag acttctgcag gtaatggact 209881 aactcaactt gaaacaatga aagataaaat acaaacattg gattatctgt ttcaaaattg 209941 caagcctgaa tttttaggtg gtacggtcga tgaatggcta aatgaaaata gcagtgacac 210001 cattgaaaaa agtgttgata tgattcgaca tcatccccta gtgccgtcat atgttaaagt 210061 tagaggttta ttcgttaatc ataagggtgg aaaaccctca atcgcggagg ttcctgatgt 210121 taaaacaggt caagccatgc ctgatcattg cttgtcatga tgaaatgcag gtttaacttc 210181 taaacgcacc catatatgga gaaagcagtt ctaaggagat tgtatgagcg ctaatttaac 210241 tgattttgtc acgaaaacaa tagaggaaat gaactcgttt gatcgtgaaa atatggaatg 210301 tataaaaaaa ctaattagaa aagcaattga tttttatcat ctaaagtctt atgaagaagt 210361 tgaggaaacc cattcaggaa atgttcgatt tttgcatgtc cactctatga tggaagaaaa 210421 tatgttatcc aaaatgatag tggtcacaag aaacggtaaa actgatttgg atattgaagg 210481 tgtatatgaa ggatatgttg taagagaata ttaatgagac gaaatcacaa atagaatatg 210541 ccaatttttt tgctcaggag atgtattaga tatgaaaaag tctaagggtt ctattgaatc 210601 agagatcagt aagtccatta ctcaatggga gaaggattat cttgggcggg ggtctgtatc 210661 tgttaagact gatatactgc gggacatgat catcgtcaat ttaaaaggga ttttaacacc 210721 agccgaatat gtagtttgtg gatcaaaaga gggtatgtta tctatcaaac aaactcgttc 210781 agagttagtc gaatcaggta tagaaggcct taaggatatt atcttaaaaa taaccggaga 210841 aaaagtgaaa agttttcata ctgatttaag ctcccggaca ggtgaacgag tgatggtatt 210901 taaattatgt aatgatctag agaaaaattt ggaaaagatc ttataatcta aagaaaataa 210961 atgttttgac ggtgtggaat ttgttgtgaa ttgaacataa agaactgccg attcttttgt 211021 tttacaatta tggtatcatt gataactttt attcatatcc taagcggaca taaagagatg 211081 tcaattcata gtacactgtc atgttattcc tgtcgaaaga tctaacatcc gctgttgtta 211141 tgagcggatg tttttttaca tctattttaa atacatgaat ttgatgctgg tgattagtca 211201 cttgaacaat atttgaaaac atccttgtca cctgccgggt ttccccaagt gtttagtgac 211261 atgattatga gaccaacttc gtaaagcttg ctgataaatt taagcggtga acaaaattga 211321 tatgctgtct tcagtttcat ttcacggaat tagtcagaga taaaccttta attaaatata 211381 tccaaaaaac ggattgacat atcgaaatat aacgatataa taatcgatat ggaaccaatt 211441 gaagtattca aagccttatc aaatgaatca aggctgcaaa ttttacaatg gctgaaggag 211501 cccgatcgtc attttgcacc ccatgaaggg attgatatga acacaatcgg ggtatgtgtc 211561 agtcaaataa cagacaaatt gaaaatgacg caatcgacag cttctcaata tcttaccatc 211621 cttttaagag ccggcctaat taaggcggag cgaatcggaa agtacacgta ttataaaaga 211681 gatgaagaag ccattgggaa acttgctgac tttcttaaaa cagagatata aaaataaaca 211741 tcaaaagatg tttattttta caccatacat atcgacatat tacgatgtgt ttattttttt 211801 ataataacat atcgataatt cgtgatatgt ttattaataa ttaaggagtg aatgttttat 211861 gtctaacact tggaaaattt atattttagc cattgtcagc tttttagttg gaacctcaga 211921 gtacatcatt tccggaattt tggatcaaat tgctcatact ctcgggatca ctttagctgc 211981 cgcgggccag cttattacca ttttctcact tgtatatgct ctttctacac ccgtacttat 212041 ggcgttgaca gcaagtatgg atagacgcaa attgatgatg tatgccctag gtttgtttgt 212101 gttcggtaat gtcctggctt ttgtactgcc tggttatgga tggtttattg cagcgcggat 212161 cattatggcg atgggagcag gtgtggttgt tgtcaccgca ttaacgattg ccgctaagat 212221 tgcatcggaa gggaagcagg gcagtgccat cgctacggtc gtgatgggat ttaccgcttc 212281 tttaatcatt ggtgttccgc ttggaagaat gatagcagta gcattaggct ggaagtctgt 212341 atttggagcc attgctttgt tgggattgat cgcaatggtc gttattttct ttactcttcc 212401 gtatactgaa ggggataagc ctgtgccttt gcttcaacag cttgctcttt tcaaaaaacg 212461 gaaagtggct atgggattat caatcacttt cttctggctc gggggatatt ctgttgctta 212521 cacttatttg tcaccgtatc tcttgaacat ctcaggtata aatggcaagc tgctcagcgg 212581 tgttttgctt atatttggaa ttgccagttt ggttggatcg aagtttgggg gatatagcac 212641 cgataaatgg ggagtgccct ttacactcgt tggcgggatg acgttgcata tcgtcacact 212701 gattctgctg tcacttgtta ctcattccta tatcggagtg ttggtgattc tcatattatg 212761 gtcgtttgcc gcatggtcca ccggtccgac acagcaattt cacctggcta caatagaacc 212821 ggaaatgtca ggtgttttgc ttagcatgaa tcagtcaatg atgcaattcg ccatggcggt 212881 cggcgcaggt ataggagggg tttttgtgga aaacgtatca ttggcctcga ttacctgggt 212941 tggtgcgtta ggggttatga ttgcaattat tgcatcattg ctgattttca attcgcaacc 213001 gaaacaagcg ctaaaagata tcaatcaata atttcgaaag ttctaacatc cgctcgttat 213061 acaagcgggt gtttttttta gcgtagtcag tccatgcatg agtcttccaa gggccgacat 213121 cgttctgtat gtgtcgaagg tgcactgaag ctgaatgaga tttcttaagg ctttgccgcg 213181 gcgagctgaa gtacagtacg attgccttga tcgaacactg gaaacacaag agaacgtaaa 213241 cctgaacatc cgcgtaaacg tcaaggaagt tgccacttgg ggagtaaaca cttgcatcat 213301 ctcgctgaaa ggcctagaca atgcggatga cagattcgta ttgccggaag taaacacagc 213361 gcttgctctg tttccgttgt cgattgcagc tgattgctta ctaatgctgc cctgcatctc 213421 ggttgtgatg tcgataagca gcgtaatgaa gagtgttact gtggagtaag atgtttaacc 213481 cctctggata ttttagccga aggggttttt agtatagata tttgatttaa attacaggag 213541 acttcattca tttaaccaaa gtcattgctt tcttaatcac taaagtttat ttgaaaataa 213601 tctcttgatt taatttcctc gaagagattt tttgtcaatc tattaggcat cagaattttt 213661 ataacataat ggaccgtctt tttgacgttt tgtttataga acaagaaaat attcaaaaca 213721 taagtggaaa attaggggtg agctcctgtt tttctcgaga ggatagcttg tcagcttttc 213781 tatttttaaa gggttaaaat attctattta tactaattaa tgtaattttt aggataatat 213841 acaaaatccc ccttacttcg acaattgcaa tctggtatta tcgtatcgca tgggagctat 213901 gtcaatagac tctatgcaaa aattgagagg aggtttactt atgaaaagaa accaaaaaga 213961 atgggaatct gtgagtaaaa aaggacttat gaagccggga ggtacttcga ttgtgaaagc 214021 tgctggctgc atgggctgtt gggcctcgaa gagtattgct atgacacgtg tttgtgcact 214081 tccgcatcct gctatgagag ctatttaaca tttgagaata gggagttgag cgtatttgct 214141 tatactcctt attttctctt aagggggatt ttatatgtca tatgatcgtg ttaaagattt 214201 tgatttgcca gagttagcgg ttcatttaca gcctcatggt gctgtaatga ttgatagaaa 214261 aagtatgttt tatttcagac tcagtggacg tggagcacag ttggcgtttc tgttatcaaa 214321 aaacaaaaat cttcataaaa cggcacgtat ttgggagatt atgaaaaaag aagagatgag 214381 tgctgaccaa ttaaaagaag agcttagtgc ccatccattt acggaggctt ggacggaagg 214441 gctgttagat cagcctttac acgtttcggg ttcgctagat tcatatttac ctattagttg 214501 taccttacag ttgacaaatg cttgtaattt aagctgttcg ttttgctatg ccagctcagg 214561 taaaccatat cctgaggaat tatctagtga acaatggata ttggttatgc aaaagctagc 214621 agcccatgga gttgctgata ttacgctgac cgggggtgaa gcaaagctga tcaaagggtt 214681 taaagaatta gtcgttgttg caagttcgtt gtttaccaat gtgaatgtat ttagtaatgg 214741 attgaactgg cgagatgaag aagttgaatt acttagtcac ttaggcaatg tttctgtaca 214801 gattagtatt gatggtatgg ataatacaca tgaccaatta agaggcagaa aaggcggctt 214861 taaagaaagt atgaatacca ttaaaaaatt atcagaagca aacattccag tgattgtcgc 214921 tatgaccatt aatgagtcca atgctgatga agtatcagat gtggtggagc aatgtgccaa 214981 tgcgggtgct tttatctttc gtgcaggaaa aacgttatct gttggacgtg cgacagaagg 215041 ctttaaggct ttggatattg attttgaaga aatggttcaa atacagctta gggaagcacg 215101 tcataaatgg ggagatcgcc tgaacataat tgattgggag cacgaagaga gttcgttcac 215161 aacagatttt tgtacaccag gatatcttgc ttggtatata agagcagatg gatacgtaac 215221 tccttgccaa ttagaagatt tgccgctagg gcatatttta gaagatagca tggctgacat 215281 tggttcacct gctcgtttgc ttcagttaaa atgtgaagca aaaaattgca aatgtatagg 215341 gaaaattgag ctatctgaac cggacttacc ttttcaaaaa gaagtcaagg cagggattca 215401 ggaatgaata gtctatcatt ggtgttctgg agtattttag cagttgttgg attactgtta 215461 tttattaaat tcaaaccccc aacaattgct tcactactct taagcaaaga tgaggcaaaa 215521 gaaataagca ttcaatttat aaaagagttt gttgggatag atgtagagaa ctgggatttt 215581 tattcagtat attggtatga ccacgataca gtaaataaac ttcatcactt aggcatactt 215641 aagaaaaata gaaaggtttt atatgatgtt gggttggtcg aatcatggag agtccgtttc 215701 gttcaccaga atcaatcatt tgtagttggt gtcaatgcca atcgagaaat cacttttttt 215761 tatgcggatg ttccgaaaaa aaccctttcg gggaagtttg aacaagtttc tccagagaca 215821 ctcaagcaga ggttaatggc ttcacctgat ggactttggt ctagagcaaa tatgactggt 215881 actggtaaaa aagaggagga ttttcgcgag gtcagtactt attggtacat agcggaagcg 215941 ggagatattc ggctcaaagt gactgttgaa ttacagggcg gccgaatttc ttatattggt 216001 actgaacaag aaatactaac agatcaaatg agtaaagtca ttcgagatga acaagtggaa 216061 tcgacattcg gagtatctgg tatgctgggt tcagctttag cgatgatcct tgcgattctc 216121 atccttgtat ttatggatgt gcaaacaagc ataatcttca gtcttgttct gggtttgttg 216181 attataatat gccagtcatt gacgctgaaa gaagatattc aattaacaat tgtaaatgct 216241 tatgatgcaa gaatgagtgt caaaacggtc agtttattag gtattttgtc tacacttctt 216301 acaggattat taacaggatt tgtagtattt atatgttcat tggcaggaaa tgcgcttgct 216361 ggtgattttg gatggaaaac gtttgaacaa ccaatagttc agattttcta tggaatagga 216421 gcagggctca ttagtttagg agtgacttct ctgctgttta acttattgga gaaaaagcaa 216481 tatttacgaa tttcacctga gctttctaac cgaactgtct ttctatcagg ttttaccttt 216541 aggcaaggat tgaatatgag catacaaagt tcaattggag aagaggtcat ctatcggcta 216601 ttaatgattc cagtcatttg gtggatgagt ggaaatatcc tcatctccat tattgtatct 216661 tcctttttat gggcggtgat gcaccaagta actggatatg acccaaggtg gatacgttgg 216721 ctgcatctat ttatattcgg ttgctttctg ggagttctct tcatcaaatt tggttttatt 216781 tgtgtattag tagctcattt cattcataat ttagtactcg tctgtatgcc gctgtggcag 216841 ttcaagcttc agaaacatat gcatcatgat cagccaaagc atacttcact ctaatgatta 216901 ggagaagatt tgatgcaatt gatgcaagta caaaatttaa gcaaatgcta tcgaaatggt 216961 gatggggttg aacatttgtc tttctcaatt caacgaggag aaatcgtggc gctattgggg 217021 ccaaatggag ctggaaaaac aacgacaatt cgatgtttga caggtctcta taagccggat 217081 aaaggagata tcctcattga gggttctcct ccaggagata taaatgttca aaaaaaagtc 217141 gcgcttattc ctgatcagcc atatttgtat cccgctttaa ctgctgctga acatattcag 217201 tttagggcaa gaggatatca tccaggtaaa aaagatgtaa aagaaagggt ttatcatgca 217261 ttgaaggaag tgcacttgga ggagaaagca aaccaattgt gtggtcagct gtcaagaggc 217321 caaaagcagc gggttgtcct ggcgggggcg attgttcaag acgctttgct gtatatatta 217381 gacgaaccga ctgtgggcct tgatatccca tcaaaacagt ggctctctaa ctggttaaaa 217441 actaaaaccg atcaagggtg ttcagcattt gtatcaactc atagtctaga gtttgttata 217501 gagacagcag acagggtgat attaattaga gacggcaaac tcatgcagga tttgtatgtt 217561 cctcaattcg aagaacaagc ggaatggaga aaagaagtga ttcgtcttct aggggaatgg 217621 tcagatgaat aatatcattt cttttttatg gcttcagtca aaaaggcgtt ttgtaagtca 217681 aggtcaggaa aaaaaaatgc cttttttgat catgctcctt tttgttgggg ccatcggatt 217741 tcaagtaagt tttgtttcta gatctacgac atgggatatg agtattgctg gttgggtact 217801 tacaggtgtt tttatccttt atacggcatt tggacttttt tcaaatcgat taccaagtca 217861 aatggcagat attatatggc tttatggcac tgccacatct ttttcaaaag ttgtgtatag 217921 tgttttattt ttcagcgtca cttggaaggc gttgctttgg atcatctcag ccatattcgg 217981 tgatgtatta attgtgcttc tgtctggtga tcatatcaat ttattaggcc gatccataat 218041 ttttgtaggg ctctttttta tcgctgaagt gtggttgatg tcggtctctt gtgccagaac 218101 agtgaagaaa atgaaaaggg tatacgtttt agtctttctt ctaatgttag gcatttactc 218161 catatgtctt tatcgcttct tctttctcca acattcatct gggatatggg agagcattgc 218221 ccgttttatt agtggcgttg gattagtgtt tgatacattg tcaccgttgt atgtggttgt 218281 atttattggg attatcacag tctcttttat gacaattgct tttacgagcc gtcaggtaga 218341 aatgaaggaa tcgttggtga aagaagctga attctgggag gaatttcaag aacgtcaatt 218401 tggttcaggt caaattatac agaaaccaaa aacgacttgg tggggcttgc aaggtctaaa 218461 tggcatttgg tcttttctgt ggttggaact gttgcttttt aaaaaatatt tattttttca 218521 tagcattcat acggtcatgc tcagtggcgt cttttatgtc gtcattttca tgtatccaga 218581 atggttttat cttctattct ttcttatcgt ctcggcagtc atgttaagtt cctattattc 218641 aggaattgtc agacattctc aatcaggcac ccttcattta ttccccggtg ccctttggaa 218701 aaaaatcatt attctagagc tgacgaatac agtctggttg tatattcttt actgtgtttc 218761 tattactttt atggcagttg ggaatttagt ttattggtat atatatggct tagggatata 218821 tatatggttc atgacaataa ggctttttgc ttttacccat acaaaccgaa acgatattaa 218881 gctttcattg cctcaatact acaagtcatt ttttatggca ttaggcctga gcggcatttg 218941 tttgtatgtc attcatttat tgactgctga ctggtataca ttagtggtgg tcgtctgcat 219001 agggagccta agttggtgcc tgttttatcg tttcagatag tggttatgta gagttattgt 219061 tttaaaacga ggagaggggc tcttttatga attcaaatgg tgataaattg tcgttatctg 219121 ttcagaattt agcgaataca aatgagatca caattgttca agcgataggt gagctaaaga 219181 aatcgggaaa agatgcaata ccagttttgg ttgaggcctt aaaagaggaa ggctctttgt 219241 gtaatattgc tgcagctgtt ttaggtgagt ttggggaaga cgcgagtgaa gcagcggagg 219301 agctatcatg tttattaaaa agtcatgcgg aagatacaag aatggcagcg gcgatttcat 219361 taatgagaat cgggaagccc agtctgccct ttgtcatcaa aatcgctcaa gaaagtgaag 219421 ggcaatcgtg cttttgggca tcttggtgta ttgcatggat tgatccgtct tgcattgaac 219481 ctaagatgta taaatgtcta aaatacgagc atgaacatcc ttcaggaata gttgctccgt 219541 ttgcggctga agaggcatta ggaaagctga ttgcttttca gctgaaagat aaggaggact 219601 gaaaggatga aagatgaaca aatgttgact gaatggccaa gtcatttacc atggttgaat 219661 caatcacaga atgattttac atttccaagt gacacatatc ttcttcttta tttttggtca 219721 atgagctgtc caaactgtca ccaattaaca gacaaagtcc ttcaagatat aaaggatatg 219781 aatgtgaaag taatcggagt acatgtcccc tatatagaag aagagaaatc tatggaggtt 219841 gtcttgacgt atgctcttga taggggacta gctattccga ttgtattaga ccaaaactat 219901 gagatcgtca caacttgtca cgtacaaggc atccccagct tttgtctatt aagtcaatac 219961 ggtcagatca ttactaaaac gatgggagat gttggttggg ataagatgtt aaaaaagatt 220021 gcaggcttgt gaaattttcc gtcttgtatg tgcgacaaac ggttgaatat tatgatgaaa 220081 cggtccttcc tataagcagg aaggtttttt aatgaaatat ttttttatta gtaggtaaat 220141 tcatcaaatg ttctgctatg ctccaaatgt acacctttcc gtaagggcaa agtcaaatgt 220201 gaaaaaaaac tgttccaaag ttaatcagaa atttattttc atattgtatc cttcggtatc 220261 aagtgaaagg agcatcatat gaaaacatta tggaaagtcc tcaaaattgt ttttgtcagc 220321 ttggctgctt tggttttgct tgtatccgtc tcggtattta tttatcacca tttccagcta 220381 aataaggagg cggcactgct gaaaggtaaa ggcacagtag tcgatgttga cggtaaaaag 220441 atgaatgtgt atcaagaggg aagcgggaag gatacgtttg tgtttatgtc cggttcgggt 220501 attgctgcgc ctgcttatga aatgaagggg ctgtacagca agttttcaaa agaaaataag 220561 attgctgttg tagatcgggc aggttatgga tacagtgaag tgtctcacga tgacagagat 220621 attgatacgg tattggaaca gacgaggaaa gcgcttatga aaagcggaaa taagcctcct 220681 tatattttaa tgcctcattc gatatccggg attgaagcga tgtattgggc acagaaatat 220741 cctaaggaaa tcaaggccat tattgcgatg gatattggat tgccccagca gtacgtcacg 220801 tataaattga gcggagttga ccgattgaaa gtgagagggt tccacctgtt aacctcgatt 220861 ggttttcatc ggtttatacc ttccgctgta tataatcctg aggtgattcg acagtcgttt 220921 ttaactgatg aagaaaaaga aatctataaa gccattaact ttaagcaatt ttttaatgca 220981 gatatggagc atgagctttt acagtcttac caaaacggca gcaaatctgt gaatctgcct 221041 gcgccaaagg aaactcccgt cttgatttta gatgcagtct ctgaccaaaa tagacattca 221101 aagtatgcta tacaaaaccg aaaagactat gaagcgtttg cggctcaatt caatactgcc 221161 gatataaagg aactgagggg aacacacagt atttatttat atcagcctga tcaaatatat 221221 aaactgtcca tggagtttat gagaaaggtt cgctaggatg aagggttatc gtattttaat 221281 cgttgaggac gatgtgatga ttggtgattt gctgcaaaag attttgcagc gcgagggata 221341 tcgtgtgata tggaaaacag atggagcgga tgtgctttcg gtgattcaga aggtggattt 221401 ggtcattatg gatgtgatgc tgccgggtga agacgggtat caaatgtctg caaaaatcaa 221461 aaagctgggg ctgggcattc cggttatttt tctctcagcc cgcaatgaca tggacagcaa 221521 gcttcaaggt ttgcagatcg gcgaggatta tatggtaaag ccctttgatc cgagagagct 221581 gctattaaga atgcggaata tgcttgagca tcattatggg acctttacgc aaatcaaaca 221641 tttgtatatt gatgcggtaa cgaaaaaagt gttcaatgaa agcctgcatg atgaggtatt 221701 atttactgcg attgagcgga aaattttctt ttatttatat gaaaatagag acagtatcct 221761 gacaaaggaa catttctttg aatatctatg gcagctcgaa gatagaaacc cgaatattgt 221821 caatgtgcat attaaaaaaa ttagagctaa aatcaatgat caagcgggtg agatgattga 221881 aaatatatat ggagaagggt atcggctgaa taccgttgtg aagaaatgaa gctcaagaca 221941 aaatatcagt tgttattgtt tacggccgtc attagtgttc cgatgctatt gctggcggtc 222001 agtgttttga tgtcggtgat ttatgacagc atgtttaaac cgatgaatca tggtatgccc 222061 tttcacaggt cgtttgcata cccggcaatg atcgttgtat ttttgatatc actcttattg 222121 ttagcttttt tattttcaaa gtcgattcat tctctgttgc ataaaatcaa tctattaaat 222181 caaaccattc ggcatttggc gagtgatcaa agggtgcccg ataaaattga agtgaagcgt 222241 gctgatgaaa tcggggaact gatcaagtcg gtcaatttgt taattgaacg gacgacatat 222301 cgtgaactgg agctgagaca gcaggaggaa atcaaaaagg agcttttgca aaaactgcgg 222361 catgacatta atacaccttt aacggctctc aggctgcagt tattttattt ggaagaccaa 222421 tgtcatggtc aggctgtatt cgaatcattg tatcagcaaa tcgaatatat ctcggaatta 222481 actaatgaat tcaatctata ttccgctgag acgctggaaa gctcttatat tgtaaatgaa 222541 gaagtgcgtc taaacgagct attagaaaca gcggtgaaaa agtgggatta tttatacagt 222601 atgagtggga ttgagctgca ctataagccg gcagatcaag atgtgatatg gatgagcaac 222661 acgttatgga tggaaaggct gtttgataat atttttcaaa atacgttaag gcattcaaaa 222721 gctaaaaaga tggaagtcac gattgaacat ggcgatgttt ttattcgtga tgacggtatt 222781 ggatttgatc ggaatgagag cagtgaggga cttgggttaa agattattga ggatacatgc 222841 aggctgcttg cgattactta tgagctgcat acaaatgata acggaacggg gttcttgttt 222901 tcaaaagagt gaccccgctg atgtttttct ttctcctata aaatttatat aatagggaga 222961 aagaaatggg gtgaacatca tatgtttaaa aaaatcatca aaacgattaa gtacctctca 223021 agcagttcta gtgaccgata tcgcagacac cggcattaca gcagcagccg gcgcagacat 223081 tatcgcagct acagcagcag ttcgggcaaa agaagacact acgaccgtta tggcggcagt 223141 catcgttaca aacgccggag ctacagcagc agttaatcca aaaaaagttc ttgttccgct 223201 tttgggacaa gggttttttt atgtgaccga ttgaatggcc cggtttagat cctcgcgaat 223261 ggaagcggtg tgctgatact cttcctcaat gcccaataat cttttcagca gcaaggttac 223321 ttcctttgtc agtgttaatt cctccagcca agtgccgttt ttcttctttt ttcctttata 223381 ttgagagtac agcaagaata acagcgtttc tccgagatcg aagaagtcat cctgttttcg 223441 tacctttatt tcctccattt cttcaggagt caattgtttg gcaaggccga aatcgatgag 223501 gcagagcctg ccatcattga tgatgatatt aggcgttctg atgtcgctgt ggaagataag 223561 gcgatcatgc aggtattcta taatctcaag cagctgcgaa atcagttgta acgccataag 223621 ctctgtgaac ggctgttttc gaaaaaataa taattcttct atattctctc cctcaatgaa 223681 ctgcatgaca taataagcct gtccgtctat gatgaattca tctatgaagc ccggaatttg 223741 cgggtggtga atgtttttga gcagttttat ttcctgctgg aatcggactt tctctttttc 223801 ctttttggct tttgtcggcc gaagctgttt taagacataa ggtgtttgag ctaggatatc 223861 ggtgcacaaa taaaccaaac cgtagcctcc cataccgagg cactcttcga ttttgtattg 223921 atgatttaag ataacgccgt tctttagagg gcggtcaaat agcagttttt ttagaagttt 223981 taatgccatg tctgcacttc ccttggttgt actgactata gtttaccttc tagacggaga 224041 ataaaaaaga gccggataac cggctcggta taagttaaaa ctgctttgtc acgtcgtatt 224101 cataatctat ttttgctttt acgttgctca tcgtcgatct ggctgtcgct aatgtattat 224161 atttaaaact ccataccttt gccacactga gttgatccga caaagagata tcataagacc 224221 ctgaagtcga gctgtttaca agggcacggc tccattcgtt attttcgctt gtcatgatca 224281 gatggcgtgt atttccctgg cttggtgttt gagtggcggt tgtttgaact ctggttacaa 224341 tggcatcacg cggtatccca gattggtttg ttaaatcaac cttgatcacg ctggagtcag 224401 aacctgaggg gctaaggctt gtatttcctt tattttcagc aacgccgctg aattggaacg 224461 ttccgctgcc tgatttgatt cggtcttcaa ttgaaagcgt aaagtacatg tttccagtat 224521 aggtgcctcg tgacactttc acatagaagg tatccgtcgt gttttgggcg tctgcatttg 224581 cataaataaa agaagaaaac gtattagggt taataacttc tgtcccttga gaaacaggta 224641 ttctgttctt gtcataaatt tcaattttca tccctgtata cgcgctctgg tatgtactcc 224701 tcatgtatac tttttctccc ttattagccg taaaagtgaa ataggcttca tcttgaccag 224761 cttccagtat tgttgtatcg atatttttat atttccaata accgatcggc attgcggtat 224821 caaatgaatt gtttcctgtg atagcagtga ctccgacagc tgatgccgaa tacgtaaagg 224881 tagataagac agaaagcata acagcgaatt gaataagcca ttttttcacc atgcaaacaa 224941 cctcctttta tttccatcat acataataac gatttaggtg taaataaatg ttttttgagg 225001 ttaatatata cattatattc gccgataaaa aagaataaga gagaatactc gggagggaat 225061 tcaatgcgtc tgaatcggca atttatccgc actcagctga ttgcacagaa catattgagc 225121 aagaatgcgc ctgccaaacg ggagaatgcg actgaaaatc cagcggcagt tctggaaaag 225181 gcatatagca ggcttaagtc acaatcttca actgggggaa tcaatcagtt caattattct 225241 aaaaccagcg tgtcgggaaa cagcgggacg ttcagcaaag tgtatcaatc agcgaatgat 225301 cgaacagtga cagacacagg ggaagaaaca gtgattcaat cccaaaaccc ctatgaatct 225361 gagagtgata tcagaatcaa aatactagat gaaaaataca gcaggatgaa tgcgattaat 225421 aaaacaaagt ctgatccatt aggctatatt aaggataagt accaaaattc aaagtctcct 225481 tatttcagaa gtgatctgtc agctgcagaa agacaggccg cttacgataa tgaaacagaa 225541 tggttattca aagggaaggc gcaaaactat aaccttcagg atgctgtgtt tcggaatgtc 225601 acatttcatg gggaagtgga agctgagaat gaaaaggtgt atcagcgggg acaggttaac 225661 cagcagctgc aagtactgtt gaatcgaaac catattcata ttccagaggg gacagagctg 225721 acgtttacaa tcacaccgat tgactatcag gtgcgggtaa gcgggacaga cgatcaggat 225781 ctgatcaagc aaattgagca agtgctgcaa tctggagaca acagcaaaga actattttta 225841 cacatcatga aaagtcaaag cagtgattca gcacaatttt ccgaagaggc ctataaaaag 225901 tatcaggcag ctcgtgagat gtatgaagtt acaggctacc atttgaagga tttagaagtg 225961 attgatgggc ggtacgtcac gcctgaggga cgtgacttaa tggatgtata taaggaagag 226021 cttgaaaaag atccagtgca gaaacaaacg gcttcttatg ctatatctta ctatcgttca 226081 gagctcagta aaatcgcgga agccgggtat aatgccattc cggatttcat cctatcaatt 226141 gattacagca atggatctct gagagatgtg ggacaaagca agagctatgg gaccggagat 226201 accgggtggc ttgaagcatt aaagcgtcaa acgggtgtga attattaggt aagctgttca 226261 tgtaggacag cttatttttt atgagaatct aaggggtgaa ttaatcccaa tattcaaata 226321 attttattat ttttatataa aagattttaa aagaagtgaa cgattcaaaa ctctgaacaa 226381 aggtgtttac ctgaaaaaaa caattgtatt ttccagagaa atttattatg atgaaataag 226441 taatttagga gattatataa caattttaag tttgaatttt ctgattgtta tcactgattc 226501 atgtgaaggc aagcaggtct gctgttttct catttatgag tattttgtta ggaggaggaa 226561 gaggagtggc aaataaagaa ttaaagaggg gcctgggcgc gcgccatatt cagatgatcg 226621 ccttgggcgg tacaatcggt gttggcttgt ttatgggttc tgccagcacg atttcatgga 226681 ctggcccatc tgtccttctg gcttatgcaa tatgcggaat ttttatcttt tttattatgc 226741 gtgcgatggg tgaaatgctg tatgtcgagc cgagcacagg ttcttttgcg acgttcggcc 226801 atcaatatat tcatccgatg gcaggttata taacagcatg gagcaactgg ttccagtgga 226861 ttatcgtcgg catgtcagaa attatcgctg tcggttctta tacgaagtat tggttcccgg 226921 atttgcctgc ttggatacct ggtatcgtgg caatggtgat tcttggtgcg gcgaatttaa 226981 tttctgttaa gtcgtttggg gaatttgagt tttggtttgc gatgattaaa atcgtgacga 227041 ttatcttgat gattattgcg ggaatcggaa ttattttctt cggttttggc aatggcggag 227101 atgcgatcgg tttgtcgaac ctgtggtctc acgggggctt ctttgcagga ggtttctcag 227161 gtttcttctt tgcactgtct cttgtcattg cagcctatca aggagttgag ctgatcggga 227221 ttacagcggg tgaagcgaag gacccgcaaa acacgctaag aaatgcgatt caaagtatta 227281 tctggcgtat tttgattttc tacattggcg ctatttttgt gatcgtgacg gtgtatcctt 227341 gggatgagct caactcactc ggaagtccgt ttgtgtctac gttctcgaaa attggaatta 227401 cggcagcggc cggcattatt aactttgtcg tgattactgc ggcaatgtcc ggctgtaaca 227461 gcggtatttt cagcgcgggc cgcatgctgt atacactggg tgtcaatgga caagcaccga 227521 aattctttaa gaagatttca cgcaatggtg tgccgctgta tggcacaatt gcggtgctga 227581 tcggtttggc tgtcggcgtt gtactgaact atatcgcgcc gccgaagatc tttgtctatg 227641 tatacagcgc aagcgtgctc ccagggatga ttccttggtt tatcattttg atcagccata 227701 tcggattcag aaaagcgaag ggtgctgcat tagataaaca tccattcaaa atgccgtttg 227761 ctccttttac aaactatttg acgattgctt tcttgctgat ggttctggtt ggcatgtggt 227821 ttaacgatga tactcgtatc tccctgattg taggcgtgat tttcttagcg cttgtggtca 227881 ttagttatta tgtgtttggg attggcaaac gcacgcaggc caatttgaca aaaagcgaac 227941 aagcagctga ataacgataa aaaagagaca ttcacggatg tctctttttt tatttttcgc 228001 gtatggattt tccctatttt agcaagctat agggtaaaga tagcagaagg aaaggtgttc 228061 ataaaatgga tgttacactc ggttatttgc gcgaatcact ttcgaatcat ctagaaaatg 228121 aagtctgcca gcgtatttgc aagaagatgc tggcgaagcg ttatgcaaat gaagaggaat 228181 ttgtaaaaga cttagatgat aatgaaatgt cttttttgaa ccatgtatta gaaaaagaaa 228241 ttaagtatgc ccagaatgaa caggatcaaa aacgggccaa ggaattaaac gaggtgtatg 228301 aattactgct ttgagaaagg cgggtaagaa atgggagcaa ttgaacgaag cggatataca 228361 tttcagccgg agtttagcgt tgtccgtcaa aacggagcca tccatgtgta ccatcaagga 228421 gaatttgtgg aagaaatcga atttgaattt aacggggaat atcccgatca tgatttgatt 228481 gaagagcttg tgaatcatta ttgttttgag catgagattt agagccctgc cgtgcagggc 228541 tcttttattt aggatgtaat caggccatac tttttcagga tatccacggt gatgtttttg 228601 gcttttgtgc cggaatcatc gacattggtg acaaagacat aagagccatg ctctgttttg 228661 atgaatccga caaaccatcc taatcccata tcagtcaggc gggttccggt tttcccgtag 228721 agcgtgtaat gatcgccttc ctcttgaatc atcatgcgct tgacgatttt catcaccggc 228781 ttgtcaaatg gaagctcctc tttagccagt ttctccaaaa aagtttcttg ttccagcgga 228841 gatattgtga gcgagctttg cagccaaaac tggtcgattc ccccgctgat atcctcgttg 228901 ccgtaagata gagtatgaag ccatgttttc attctttcct cgccgatatc tctcgctaat 228961 gcctgataat accagattgc ggattcgcgc atggccgagc caagcgtatg gtcgcggttc 229021 catgattcga attcacgctt gaccccgtcc catcgtttaa catcgtattc atctcttaca 229081 gctttgacct gcaaaccgat taaagcgttc acgactttaa aggtggattg cggagtttgt 229141 ctttgatttg cccgttttct gttatagaca aatgtctgat ccttttgtaa atcgtgaaga 229201 atgaaggttc catccgtatc cttgaattca tcatcgacat tcattttgct gacattcaag 229261 tgtttttcat gagcagatga tgctgcgtgg acggagaagc cgccgatccc tgcaatactc 229321 agcacaagca caacatatat ccattttttc attttgttct ccccttcgtt ttgattaact 229381 accttttctc tctttcgttt gttcttcctt taaaaaataa tcaaaaagcg cttaaatttg 229441 gttttgcaaa caaatactgt tactgggttt atagtcggaa gataacgtga aaatagaggg 229501 taaaaaggaa ggcagggtaa gcggatgaat gagcagattc cacatgacaa aagtctcgat 229561 aacagtctga cactgctgaa ggaagggtat ttatttatta aaaacagaac agagcgctac 229621 aattcagatc tgtttcaggc ccgtttgttg ggaaaaaact ttatttgcat gactggcgct 229681 gaggcggcga aggtgtttta tgatacggat cgattccagc ggcagaacgc tttgcctaag 229741 cgggtgcaga aatcgctgtt tggtgttaat gcgattcagg gaatggatgg cagcgcgcat 229801 atccatcgga agatgctttt tctgtcattg atgacaccgc cgcatcaaaa acgtttggct 229861 gagttgatga cagaggagtg gaaagcagca gtcacaagat gggagaaggc agatgaggtt 229921 gtgttatttg aagaagcaaa agaaatcctg tgccgggtag cgtgctattg ggcaggtgtt 229981 ccgttgaagg aaacggaagt caaagagaga gcggatgact tcattgacat ggtcgacgcg 230041 ttcggtgctg tgggaccgcg gcattggaaa ggaagaagag caaggccgcg tgcggaagag 230101 tggattgaag tcatgattga agatgctcgt gccggcttgc tgaaaacgac ttccggaaca 230161 gcgctgcatg aaatggcttt tcacacacaa gaagatggaa gccagctgga ttcccgcatg 230221 gcagccattg agctgattaa tgtactgcgg cctattgtcg ccatttctta ctttctggtg 230281 ttttcagctt tggcgcttca tgagcatccg aagtataagg aatggctgcg gtctggaaac 230341 agccgggaaa gagaaatgtt tgtgcaggag gtccgcagat attatccgtt cggcccgttt 230401 ttaggggcgc ttgtcaaaaa agattttgta tggaataact gtgagtttaa gaagggcaca 230461 tcggtgctgc ttgatttata tggaacgaac cacgaccctc gtctatggga tcatcccgat 230521 gaattccggc cggaacgatt tgcggagcgg gaagaaaatc tgtttgatat gattcctcaa 230581 ggcggggggc acgccgagaa aggccaccgc tgtccagggg aaggcattac aattgaagtc 230641 atgaaagcga gcctggattt cctcgtccat cagattgaat acgatgttcc ggaacaatca 230701 ctgcattaca gtctcgccag aatgccatca ttgcctgaaa gcggcttcgt aatgagcgga 230761 atcagacgaa aaagttaaat taaaaagctc tcttccttta tcgaagagag ctttttgatt 230821 acttcttttt ttcatcgtag tattggacgg gatacatgga gccttctgat accattttgt 230881 tgtcctcgat atcttgcggg tccgggtggc cggctttatc aactgggaac gtttccatgt 230941 ctggctgttt tgttattttc atcttcatgc tgtgaatgaa ttctcttgcc ttttggcgat 231001 ttgacgggtc ttttaataga taagaagtga tgccgacagt tgaaacagcg agacctgaaa 231061 gtaacagctt ttgtttcatg gtgatactcc tttctatttt aagaatagtg tttcctgtat 231121 cattcccgtt ttggaaattg ctaaacctgt tgtgttttta tcattggaat taacagtaaa 231181 ttccatttaa gaagaaacta gtgacttcat tcctgtattg gaaggtaata tacattgact 231241 tattatagat ttcagtcaaa attcgataaa tattgacaaa gtaaagtaat cagaataata 231301 atataattag caagagaatg tcatcataca tgaaaggtgt ttacgatatg aatcaattgc 231361 atcgaagaat gggaacgttt tccctcatga tggtcgggct cgggtcgatg atcggttcag 231421 gctggctgtt cggggcttgg cgtgcggctc aaatagcagg accagctgct attatttcat 231481 gggttattgg aatggtcgtc attttattta ttgctctttc ttatagtgaa ctaggttcta 231541 tgttccctga agcgggggga atggtcaaat acacgcaata ttcacacggt tcgtttatcg 231601 gttttattgc gggctgggcc aactggattg cgattgtgtc cgtcattccg gttgaagcgg 231661 tggcctccgt tcaatatatg agttcttggc cttgggaatg ggcgaaatgg acaagcggtt 231721 tggtgaagaa tggaacgctg actggggaag gactagcgtt tgcctctgta ttgcttctca 231781 tttattttct gctgaactac tggacagtca atctattttc gaaagcgaat tcattaatta 231841 cgatttttaa aattattatt ccgggtctta cgattggagc tttgctgttt gtcggattcc 231901 acggagaaaa ctttactggc ggtcaaagca ttgcgccgaa tggctgggca agtgtgctga 231961 cggcggttgc cacttccggt atcgtttttg cgtttaatgg tttccaaagc ccgattaata 232021 tggcgggtga agcaaaaaat ccggggaaat caatcccgat tgcggttgtt ggctctcttt 232081 ttgttgcgac agtgatttat gtcctgctgc agatcgcctt cattggagct gtgaatcctt 232141 ctgatattgc tcacggctgg agccatctga attttaattc tccttttgct gatctggcga 232201 ttgcgctgaa tattaactgg cttgttattg tgttatatgc agatgcattt gtatcaccgt 232261 ctggaacggg gattacgtat acggcgacaa cgtcccgaat gatttacgga atggaaaaaa 232321 acaaatacat gccgagtata ttcgggaagc ttcatccgat ttacggcgtt ccgcgacaag 232381 caatgttctt taacttgatt gtttcgttca tctttttgtt cctgttcaga ggatggggcg 232441 tattagcgga aattatttct gttgctacgt taatttctta tatcaccggc ccgatcacag 232501 tgatgacatt gagacggacg gggaaagacc tgtacaggcc tcttcgttta aaaggcttaa 232561 atgtgattgc tccgcttgga tttatctttg cgtcactggt gctgtattgg gcgcgctggc 232621 cgttaacagg acaggttctg tttattatcc tgatcggtct tccgatttat ttctattatc 232681 aggcgaaggc gaaatggaaa gggtttggcc ggaactttaa agccggcgtc tggatggtgt 232741 tttatctgct ggccatgatg gttatttctt atttgggcag tgataaattc ggcggcctga 232801 atgtcattca ttatggctgg gatatggttc tgattgcgat ggtatccctt gtattctatg 232861 tgtgggcgct gaagagcggc taccagacag aatacttaaa ggatgcgaaa gagataaatt 232921 ctcagctgct taatggacag tcagaagctg ctgccggaaa agaataaaat atagaagaaa 232981 accttgcgat agttgtcgca aggttttttg cttttaataa ccctttttta ctttgtggaa 233041 aagatcagga tagttggtga acactcctgt tacgccccaa tcaagcaggc gatgcatatc 233101 agcttcatta ttgactgtgt aaggatgaag caggaggccg tggctgcgga tcatacggac 233161 gttttcttga tttaaagctt tataatccgg gcccgcaccg acagcgtatg ttttgatttc 233221 ttccagggca gcatctgtca ttgacgccat ttgtttggct tccagcaatt gaacggtcgg 233281 caggtttggc tgtaattgat ggacttttac caggctttct ttgctgaacg attgaatgat 233341 cacctggcct ggcttagaat gctttcccag taatttatgt ttctgcaaag aagcgatcag 233401 tttttcttcc atacctgggt aggtgtcagg cgattttgtt tcaatgtagt agttcgcgtg 233461 ctttccgaaa cggtctaata cctcttctaa tgtaggaact ttaaggccga cgtactgcgg 233521 ctttgctttt tccggatagg cttcattaaa ccaagaaccg gcgtcaagct tcttaatgtc 233581 tgcgagcgta tggtctttca cccaacccat tccgtttgtg gtgcggtcca gtttttcgtc 233641 atgcatgaca atcaattttc cgtcttttgt catttgcaga tccaattcaa taaaatcagc 233701 tttcattttc tgagcggttt cgtaagacag aatcgtgtgc tcaggcacat atccagaagc 233761 ccctctgtgc gcgacggtca ggatacggtc aggtgacagc aggtttcctt ttgacgctgc 233821 cgacactggc gttaccataa atgagagtaa gcccagcgac agaacaaaca aggccagtat 233881 tctatttttt ctcatgattt ctcctcctta tagataagca ctacctgtct ttcataataa 233941 aaaacggatg taaacggcgt gttggaaaac tattaatctt ttatgtgtct ttcttaaaca 234001 tgctctgccc gttttcctgt attccacgtc aaagccaaga agacgatggc aagaatgcag 234061 gatgagatca gcatgataaa gccgccgttc cagttaaaac ggtccacgac aaagcccata 234121 atggcgtttg cgaaggcgga tccgccgatg tatccgaaaa atccggtcaa accggctgca 234181 gttccggctg cttttttcgg tgctaggtca attgcttgaa ggccgatcag cataacaggt 234241 ccgtagatta agaagccaat gctgatcagg gcgatattgt ccacgagcgg attgccggcc 234301 ggattcagcc agtacaccaa tacggcaatg aaaacacccg ccataaacaa aacgcctgcc 234361 ggtgcccggc ggcttttgaa gaatcggtca ctgatccagc cgcacaagat cgttcccggt 234421 atgcctgcgt attcgtaaag aaaatacgac cagcgtgagt cttcaggaga aaagcctttg 234481 gcttctgtta agtaagtagg cgcccagtca accacgccgt atcgcacgaa ataaacaaat 234541 acattggcaa aagcgatgta ccaaagaaat ttgttgttca gcacatattg aaaaagaatt 234601 tcttttgttg ttaattcttt ttcctgattt ttaaaagcgt gttttggata gtcattccga 234661 tactcttcaa ttggcgggag tccgcaggat tgaggcgtat cacgaaccaa taaaacaatt 234721 aaaaatgaaa tgataatggc gatgatggca gggaagaaaa acacgctttt ccaagtgacg 234781 aacatcgcga tcccaagagt gacaagcgga gcaagaatac cgccgcctat gttatgggcg 234841 acattccaga tcgacatttt tgtgccgcgt tcacttatgg agaaccaatg ggccatcgtc 234901 ctgccgcatg gcggccagcc cattccttga aaccatccgt tgataaacat aaaaataaac 234961 atgatggtga cgctcgaagt cacccaaggc attgaaacga atagaatatt aacgattgct 235021 gataaaaata ggcctgtcgc cagaaaatat ctcggattac agcggtcaga caccattccc 235081 atgatgaatt tgctgaagcc gtacgcaatg gacacagcgg ccagcaccaa acccagttct 235141 gttttcgaaa atccctgttc ctgcagataa ggaatggcaa aggcaaagtt tttccgcagc 235201 aggtagtagc ctgcgtagcc aatgaaaata ccaatgaata cttgcagtct gagccgtttg 235261 tatgccgcat ccatctttga atcatccagt ctctcaatat gaggagccgg tttaaatata 235321 ttaagcatta ataattatcc ccctttgctg tttgtgctgg atgtgtggcg tgcctccttt 235381 cccgaaaaac aaaaagagcc agaaaacacc ccttgtcaaa aggggttgga ttcctggctc 235441 tcctcatctc catccaagct attaacttat catgatagcg ctttcttaaa ttatcatagt 235501 ccggagcgaa tgtaaacggg taattttcaa attgggcctt agggaagtga atattatcct 235561 tttactaaat gcaattatat ttttttacta gtaacataaa aatctggagg gaggctgttt 235621 aaagatggat gaattagata tcgcattctt tattttaccg ttaggaatta tgctgctatc 235681 gattgtcggg acctgtattt gtaaaaaccc gtatctgatg ccaatgctta gtttggtgat 235741 ttctcttgtg ctcaccttta ccatttttaa tcaatcattt ttgggatggg ctgttgtcta 235801 tagcttggtt tctctggctt tatcctatat cacattgatt gtggtaagga aaaggaagga 235861 atcaggaaat taaaaagacc tcactttcta acatatcgtt gactaaagca actatatgtg 235921 attataattg ctttagtcaa cgatattaga aagtgggaat tgatttgaaa acaagagaat 235981 catctgtcgg gttaaaattc agaaagttca atcgatttta tacaaacgtc cttggtttcc 236041 ttaatgagca catttacgac agcccgtttt ccttaacaga aacacggatt ttatttgaga 236101 tttataatac gcctaattgt acggcaaaag ctcttcagga taagctgggg cttgaccggg 236161 gatatgtcag caggattgtg aagcagtttg aaaaagaaga tttgatttat aaacagagga 236221 gcaaagatga cgcccgccac cattacattt ttgtcacaga aacaggaaaa acgatttata 236281 aaaagctgga ggagaaagcc aacgaacaag tagaactgat gctgaaggta atcaaccaaa 236341 aggagcagca caagcttgcc gaggcgatgg cagagattga agcgatcctt tcacagtcgc 236401 tttctgccag agcatcagag atatcgatta gagattattt tctttcggag gatcttcaac 236461 tccttattga gaaacaaaga caattttacg cggaggctca cggttgggat gacacgtttt 236521 tagcttatct tcaggagaca tttgacgctg acatcgaaaa aatatggatt gcggaaagcg 236581 gcgggaaatt tgccggctct gtcgggttgg tcaagcacga tgaaaagaca gtccagctca 236641 gatggtttct ggttgatgcg gattttcggg gcagggggct tggcacgcaa ttgctggagc 236701 atctggttgc atactgccaa gacatgaagt ttgaccgcat tttcctttgg acggtgagca 236761 cgatggctga ggctcgtccg ctctataaaa aatttggatt caggataagt gaagtaaaac 236821 aagaagcgcc attatgggga cagcagctga cagaagaacg gtgggatttg gagctgtcat 236881 gaaaagactg cattatgcgt ggatcatcgt ctccgtcacc tttttgatct tattggcggt 236941 tcagggggtg cggctgtcgt ttggtgcgtt tgtggagccg tgggaacggc agttttcaat 237001 cgatagaagc accatctcgc tgatttcgac ggtgagtttt attgtttatg gcatatcaca 237061 gcctgtgatc ggtcggcttg tggacaaatg gggtgcccgg gctgttttgg catggagtgc 237121 gttactgaca ggagtcagca ttttcttaac ataccttgtg acttcgcctt ggcagctgtt 237181 tttgctttac gggctgggtg tctcgcttgg agtgggcgga gcatcgaatg tggcggcaag 237241 tgtattggtc gtcaattggt tcagcaaaaa gcggggacta gcctttggga tcatggaagc 237301 aggctttggc gcggggcaaa tgcttctcgt tcccggctca ctcatgttga tccattggtt 237361 tagctggaag ctgacggttg tggtgttggg actgctgtta atcgtgattg tctttccggc 237421 tgcgctgctg atgctgcgga acaatccttc agaaaagaat acagagccga taggcggact 237481 ggctgcatca gaaaaagaaa cagcacccaa aacaacagct ctttcagtgg ccgggatgtt 237541 tcgtatgagg caattctggt tcttgatttt tccgtttttg atctgtggat ttacgaccgt 237601 ggggctgatg gatacccatt tgattccgtt ttctcatgat catggctttt caacgacagt 237661 cacgagtgct gctgtcagtc tgctagcagg ctttaatatt gctgggatct tgctgtccgg 237721 aattgtagcg gaccggtgga gcagccggaa aatcctgtgc attttatatg cggtgcgggc 237781 gctgtcgatc gtgattctta tttacagcca cgagccctac ttgcttttag cctttgcgat 237841 tctgtttgga ttagtggact ttgcaacggt agcaccgact caaatgctcg ccacccagta 237901 ctttcaaaac tactcgatcg gcctcatgat tggctggctg tcactcgccc atcagatcgg 237961 atcggcacta ggtgcgtatg tgcccggcgt catctacacg gtaacgggtg agtatacact 238021 ggctttttat ttgtcgattg gaatgctcgt gcttgcgagc gtaatgaatg tgatgctgag 238081 ggagccagct gcggttacgc gtgacagtgc ggctgtggta gacaagtgat gaggacaaag 238141 ggaaagcatc tctgatttcg agattattca gagatgcttt ttttgtattt ttgttctaat 238201 acgaagtcga tcataccgac tatgcgggcg ttttcggatt tttgtttgaa gcgttcagaa 238261 atttgaactt ttcttgaaaa tggggaaaca ataaaaaccc aaaaaaggcc gatcaaggca 238321 aaaaacattt gtacagctaa ttctattaat tcattaaaac gagtgctgaa aaaatagaag 238381 tataacgtta ttaatgtcac agtacatacg attttggcaa gtgtgtttga atgtaagcaa 238441 tggttcacta aagaatacct ttaattgatt cagcatgatt gaatcatatt tgtttaggaa 238501 aataagaagt tctttatcat cttttttatg ttctaaaata aagttgctgt ttctgtttct 238561 ttatatgtat ggtggtctac attcaatata tacatctctt aaagtataaa aattgagtat 238621 ttcttagtaa ggatgaaaca aaattacatg atttttttgt tatatctttc agttagaata 238681 aaatctataa ctcctctcat tcgcaaatat tcggctctct gtgcaaagtg cagaacagta 238741 tgtaattgtc cttttctaga tatatttaaa agctttatca aatcaataag gattttcaag 238801 aaaataatta ataatagaaa gataaaaatg tgtggtatgt caatgtaatt gatttgtcct 238861 gaaaataaag aagttgcata gacaacaata atacttccgc aaaacatcaa actcatataa 238921 tgtggaaggg aaaatggacg agttgaaaaa tatgctttta attggcttag catagcatta 238981 tctcttgtat ctaagtagcc caaaagctct ttatcatttt tactaattgt aagaacatga 239041 ttcaatacag cactaaaatt cattgaatct tcattatcag aggcagtatg tttattagcc 239101 tgtatgtttt gttgatccat tttatatttt ttataaagta ttgtattaat taacttgttt 239161 ttctcataga attcagatcg ttgattaagg gatgcttttc ctttgttttt atttcctttt 239221 tttatgattt tagtataagt cataaaaata caaatgactg taaaaataga aaacactgca 239281 ggtgaaatat ctgaaagaat agtattggtg aagacttctt ttgcttggat gaaaaggaaa 239341 gaagctaaag tcatagatat aaacatgcat aaaactgcta ctttcacaag aaactgaagc 239401 ggaagagaag gttccgaata atagtgcttc aactggttga gtgtcagaga atcttggcga 239461 aaaagataat ctattatctc ctgctgattt tgcatctgat tgatatcatg agcgatgttt 239521 tttgtttttt caaaaactat ttgatcattt ttcatttttg ataaacctcc aaaagacgat 239581 agataaacta aaaaaactgc atgagcatat tttaacttat gttcatgcag ttttgtatta 239641 aagttagcta gtataataag caaaaatggc cagtaacata gcagataatg cggtagcgac 239701 tttgactcct ttattgttcg ttaaatcact gcccatattc ccaattagta aaagtgcagc 239761 aacacctaca acagggaata aatattgatc ataagacggc caatctaacg ctaattcact 239821 ctcgggagac gtaactggta ctcccttgta cgtctttatt ttaaacgtaa tcgtagtcgt 239881 tagtccagtt gtgacattgt caccgactgg aatatcaggt gtatagattt taatttgaat 239941 gtttaaagat tcagctgttg gatttacata aacctccaaa taaccgttgc gtactgataa 240001 gctcagacta tttaaaaggt tttgataaga gtcgatttgt gacgcagtga gagacgtttg 240061 agtgtcgccc aataaacccg tgatataggc acctggttta ccatttgtaa tggtaattgt 240121 gtttggtgaa ccttcacttg gtatggttgc cagaagtgaa gttgatagaa taatatccaa 240181 ctcaggtgat gtgaaaatgg tttctgtcgt atcaaattca aacatcgcgt ttgccagact 240241 tgttagattt tctaaagctg gaatggtaga taaaatgtct gtcagtgtac gcagtcttgc 240301 atcatatacc ggatcagacg gcggatttac attgcttgca cctgagtctc ttcctgaata 240361 cccgtcttta tcaatcccga tgcttccaga gccgcttccg atggttcctt cataaaattg 240421 atcaaaggcc cagttgtttg gcatcggata gccgagattg ccgctaaatc ctgttgacat 240481 atttgccaca aaactatact ttgtcagtcc tgcttcagat gtacggatac aaatgtttct 240541 tggtccgtaa acccctattt catacttagg tgcggttgaa aatgtctgca tttttgtaaa 240601 tgctgactta atctcttgga aataaggaat gattttatcg gtcacttcat aatcgtatgc 240661 atcaaaatcg acagcgaaat aaatggtcgt gcctgacgga aaacctaatc ttctagcagc 240721 agaagcggca ctatatgcat ctcttgtgcc ttggtctttg acaaaataag aagattcata 240781 gccgccgtct tgataaattg ggaaaacctt caatccggca tcaagaataa ctgcaagctc 240841 tttagatgtc agggctttag atgtgaggcc gctgcttgtc cgcacatttc cggtcaaata 240901 tctgccaacc gttttataac cgttattccg cagtgtttga gctttttctg cggttataat 240961 tgtagcagtg tcacaagcag aagcggtgcg agttgtgtct cctgagcttg ataataaagc 241021 tttaatggtt ggcatatctg cataacctgt ttgcggcagg cacatgaact cttgaaatgc 241081 tttaacagct gaaacaacac ccacaccata tttgccgtca aactcaccag gatcgaacga 241141 ttttccgtta caatagaggg cgtactgaac aattaagaca aatcctgttc ttgaatcgcc 241201 gggagttaaa gtagggcaca aacttgtggt gccgtttccg aaaaatccat tggcaacact 241261 tgtgctcatg ccttcttctt tttgcagggc ataaataaga gctttatttg tatcgcggcc 241321 atacagtccg tcacaaggca ttaacccgat atagtcattg tagtctcgat ttaagttttg 241381 ttgaatctgg cgaattcttg aatcaccccc agacaccagc ttaaaagcgc tcatgtctaa 241441 taaggctttc ataattaacg tggtgacaat cccatcctgt gttgtcagtc cggcagcttt 241501 ttgaaattct tttaccgcat tttctgtttt ttcgtaaaag acgcctgtaa aaccgccggg 241561 attaaagcct ttacaccata aagccccttg taaaataaaa ttcatgttgc ttggttttga 241621 atctggagct tggcgtttaa gaggcttaaa taagcgctgt gttgtcggcc cgaagttatc 241681 ggctggctct gagataccca attcaatttg aagcgcccga gtcagaccgt agatcgtatc 241741 ccacccagtt ttcccgcttt cttcaactgg gttataccca tgtttgccgc tgtacgtatc 241801 gttcagccat tgctgtgtga ttaagaccat ttcatcaacc atttcgattc ctcctttgtt 241861 agattgcgtt catttatagg tggcaaacgt aggacaaaat aaaaaaatgg atgccgttaa 241921 gcatccattt tacatccgtt ctccaacagc ttcgctttcg gtttcagctc tgaaatgtag 241981 aggcctaaaa gtgtaagcgc gcctcctaga agagcgatcc atgtcatgtt ttcgtgcaga 242041 atcaggacag aagcggcgat cgtgataacc gggaccatgt aaatatacgc actggatttg 242101 acggctccga gcactccaac tgaataattc caagtggcga agcacagggc agaagcgcca 242161 atccctaaga aaagcatgtt gagtatattt gaagcagatg aaaatcggct taggtcaaaa 242221 tggaagtcga acaaaaataa agcgggaacc ataaacaata aaccatacaa aaatactctc 242281 tgtgtcagct cgatgatgtg gtattcgtag gcgcttaatt ttttcatgaa tatcgagtat 242341 ccgccaaaca cgagagcagc cccggctgcc atgatgtctc cgagcggatt tagacgcagt 242401 accacattgc cgttaaacgt aatcaataaa agcccgatca gtgccgagat aaatccaatc 242461 aaaaaagtca gacgcaattt ttcgccttcg agcagaaaat gggccaaaac cgcagtgatc 242521 atcggtataa tggacacgat catgccgaca ttggaggcgt atgtataggt gagagctata 242581 ttttctaata gaaagtataa ggttacgcca aataaaccag ctccggcaaa caacagctcc 242641 tgccgccaat ttctgaacgg aatcatgttg ggacggacga ggataagagc gataaagccc 242701 atcaaaaacc gataaaataa tatttccatt ggagagaagt cagccagcag aacttttgtc 242761 gaaataaagg tcgtccccca aatcagaatg gtcacaatgg ctgcgatatg ccccgaagtt 242821 tctctttgta tgttcatctg tgaagctcct tttcaaaaat cttcatgtat tgcttcggcg 242881 tcagccccac ctgccgttta aaaaacttcg tcatatgact ctgatcgctg aatcctgtct 242941 gaaatgccgc atcaatcggc cttacccctt gttcaaggag ttttttggct tgattaatcc 243001 ggattgtttc catgtagcta ttaggggtaa tgcctttttg ttttgtaaat gaacgcaata 243061 aatgatactt gctccagcct gttaattcac tcaaatcatt gagtgtaaca ttttcggcat 243121 aatgctcttc taaaaattca caaaccattt tgacttcgtc tgatggttct ggaacgctgc 243181 taaggaacgt gacatctgaa taatggcgga tcagctcctc taatagatga agaaacagct 243241 cctccttacg caaagcttgt ttttcctcgg atatcaaaat atgcaattcc tgcaggctgg 243301 ctgtcagctc atggcggaat aacacatgct gggagaaata agggagatgc ccggagccag 243361 taatctcttt caccgccttc tccatgatat ccggcatgac attgatacac cgataatcaa 243421 gcgtccggcc gtcaatctgt tcacagctat gcgtgtcacg ggggttaaag aggagaagat 243481 cacctggatt gatgatatat tcttgatcct gacaggccag ataccgttgc cctttttcaa 243541 taaatccaat cacataataa tcgtgaaagt ggttcgggaa cttctgcata attcccttga 243601 agcggtaggc ttctatatga aggtgtgggt caagctgcag tgtgcgggtt tcgttttgca 243661 tgggatgcct cctgtcggtg tggtggtctt ggattaagtg tagcatgatt ttgggggatt 243721 tcttgtatga tgttgctgtt taggaataga gaaagcagac cgttatttgt ctgctttcgt 243781 ttaagaattt aaaagatttt aaccctcaat aataatttta tcttttttaa taaaaattta 243841 tttttcaaat atttcagtta taatggtttg gaacagatag gaggggcaaa gatgtatcaa 243901 tcaaagaagg ttttattgtt aggttcaggt gaattaggta aagaggtagt gattgaagcc 243961 cagcgtcttg gggtacagac ggtggcagtt gacagttacg agcatgctcc ggcgatgcag 244021 gtcgcgcata acagttatgt cgttgatatg ctggacccag agcagatcag aaccatcatt 244081 gagaaagaaa atccggattt gattgtgcct gaggttgagg cgattgcgac ggatgaattg 244141 ctgaagcttg aagaggaagg atttcacgtt atcccgaatg cccgtgcggc caagctgacg 244201 atggatcggg aaggcatcag acgacttgcg gcggaaacgc ttggacttgc gacagctggc 244261 tatgaatttg cgaatacata tgatgaattt atacaagcgg cagctcagat cggttttcct 244321 tgtgtcgtta aaccattgat gagttcttct ggaaaaggcc aaagtgtgtg ccgctctgaa 244381 gcggatttag agagctgctg ggagacggcg atggaaggcg gacgggtgaa aaacggccgc 244441 gtgatcgttg aggagtttat ccctttcgaa tcagaaatca cactcttaac cgtacgtgcg 244501 gttaacggta cggcattttg tgagccgatc ggtcatgtgc aaaaggacgg ggattatatc 244561 gaatcgtggc agccgcatga tatgacagag cagcaaatag aagaagcgaa gcatattgcg 244621 aaaacgatca cggatgagct tggcggatac ggcctgtttg gtgttgagct gttccttgcg 244681 aaagataggg tatatttcag tgaggtatct cctcgtccgc atgatacggg tcttgtcacg 244741 ctggtgacgc aaaatttgtc agaatttgcg ctgcatgtcc gggcgattct cggctttccg 244801 attacagaaa tcacacagct ttctcctggc gccagcaggc ccctcaaagc gccggaagaa 244861 ttagcggatt acactgttga aggattggaa aacgcactgg cagtcccaaa gactcaagtg 244921 cgcgtctttg gaaagccgat aacaaaagcc ggacgtcgta tggcagttgc gctttctgct 244981 gctgattcag ttgaaacggc aagagagaat gcaaagaaag cgttggacca gctaatttta 245041 aaatagagtt tgaacaggtc ttgtcatggg acaaggcctg tttttttctt tctccgtaaa 245101 agttttatca taagaatcag aaacctgatt ataatgtaaa agtcttccat cgatacgggt 245161 ggttgacact aaaggaggga gatgacaaaa tgaaattagt tccaagattc agaaaacaat 245221 ggttcgctta cttaacggtt ttgtgtttgg ctttggcagc agcggtttct tttggcgtac 245281 cggcaaaagc ggcagagaac ccgcaaactt ctgtatcgaa taccggtaaa gaagctgatg 245341 ctacgaaaaa ccaaacgtca aaagcagatc aggtttccgc cccttatgag ggaaccggaa 245401 aaacaagtaa atcgttatac ggcggccaaa cggaactgga aaaaaacatt caaaccttac 245461 agccttcgag cattatcgga actgatgaac gcaccagaat ctccagcacg acatcttttc 245521 catatagagc aaccgttcaa ctgtcaatca agtatcccaa cacttcaagc acttatggat 245581 gtaccggatt tttagtcaat ccaaatacag tcgtcacggc tggacattgt gtgtacagcc 245641 aggatcatgg atgggcttcg acgataaccg ccgcgccggg ccgcaatggt tcgtcatatc 245701 cgtacggtac ttattcaggc acgatgtttt actccgtcaa aggatggacg gaaagcaaag 245761 acaccaacta tgattacgga gctattaaat taaacggttc tcctggaaac acggttggct 245821 ggtacggcta ccggactaca aacagcagca gtcccgtggg cctttcctcg tcagtgacag 245881 gattcccatg tgacaaaacc tttggcacga tgtggtctga tacaaagccg attcgctccg 245941 ctgaaacgta taagctgacc tatacaaccg atacgtacgg ctgccaaagc ggctcgcctg 246001 tttatcgaaa ctacagtgat acagggcaga cagctattgc cattcacacg aacggaggat 246061 cgtcatataa cttgggaaca agggtgacga acgatgtatt caacaatatt caatattggg 246121 caaatcaata aatacagcaa actagccata ttcatgtcta ttttgttttt atgcgggtgc 246181 agttcgcaga cgcattcttc tcaaaaagaa acgactattc ctgtcactct tcatgtggag 246241 gatgctaagg ggctgccggt cgaaggggtt caagtgacga ttgtcaaagc gccctcttca 246301 gatgaggagc cgagtacaga gattggcgag atactcggta aaacagacaa aaacggagat 246361 atcaaatggg ataccggcag aaaaggcgat tactcagtcg cgttgacgaa gggtgaaaca 246421 tcagtaaccc atcacatctc gttaacagag gataaaaaag atcatgccat tccattagtc 246481 ttcaaagaat agcagtttcc ttgattttaa gggaactgcc ttttttattt attgcaggaa 246541 accaaactat atactggaaa tttattatgt gagataataa gaaataggta ttttttctta 246601 cgagacaaaa ggggcgttat cctttatatc aatcaaaccc ggaggaaaaa gaagaagatg 246661 atacaagatt caatgcagtt tgccgcggtt gaaagtggtc tgcgctttta ccaggcatat 246721 gatcaaagcc tttctttgtg gccgattgag tcggaagcat tctatgtttc tactcgtttt 246781 ggaaaaacac atatcattgc aagtgggcca aaggacgcac cttcgctcat tttgcttcac 246841 ggaggccttt tcagctctgc gatgtggtat ccgaatatcg cagcgtggag cagtcaattt 246901 cgtacatatg cggtcgatat aataggagac aaaaataaaa gtataccatc agcagccatg 246961 gaaacgagag ctgattttgc agaatggatg aaagatgtct ttgattctct tggacttgag 247021 acggcacatc tggccggcct ttcgcttggc gggtcccata tcgtgaattt cttactccgc 247081 gcgcctgaaa gagtagagcg ggcggttgtt atcagtcccg ctgaagcgtt tatttcattt 247141 catccggatg tctataaata cgctgcagag cttacagggg caagaggagc tgaatcatat 247201 atcaagtgga tcacaggcga cagttatgat ctgcatcctt tactgcaaag acaaattgtg 247261 gcgggcgtgg aatggcagga tgagcaaagg agcctgaagc cgacagaaaa cggctttccg 247321 tacgtgttca cagaccagga attgaaatca atacaagtcc cggtacttct gatgttcggt 247381 gagcacgagg ctatgtacca tcagcaaatg gcctttgagc gggcttcggt attggtgccg 247441 ggaattcagg ctgaaatcgt aaagaacgcc ggacatctgt tatctctgga gcagccagag 247501 tacgtcaatc aacgcgtctt gtccttttta tgcgggggga taaaatagta aggaacatga 247561 aaagattggc attcattttt caaaaggtaa caaatgttgt ataataatag aatttgaatg 247621 ctgctttttt tgggagcatt ctatgttatc atgcttattg gagaaaaatt tttcctgtaa 247681 cgctattcga tcactatcgt caaataatat agatggtttt acaattggag gtttggttac 247741 actgtgaatt acatcccctg tatgattacg ataggaaact tcatttgcgg attgctggcg 247801 attcattcct tgctatatca caacattcat tcagcagtgc tttttatttt tacaggcatg 247861 ttccttgatt tctttgacgg gatggctgct cgtaagctga atgccgtttc tgatatgggg 247921 agagaactgg attcgtttgc cgatctggtt acgtttgggg tggctccttc tatgcttgct 247981 tacagtgtcg cgttgtatac cctgccattt atcgggatct tatgcgcatt gacgtacagc 248041 atttgcggaa tgcttcgcct ctctaaattt aacattgaac aaagcaagct cccgacgttt 248101 atcggtatgc cgattccgtt tgcgggcatg tgtctcgtta ttctaagctt cacctataac 248161 ccgatccttc tggcaatcgg cacttgcgga ctctcatatt tgatggtgag taaaataaaa 248221 ttccctcatt ttaaaaaaca tgcggcagaa aacctggagt ctgggagatg gaattagttc 248281 agcagctcat agcggattac ggttatctcg ctattttttt gatgctggta ttaggaattg 248341 taggattgcc gattccagat gaagtgatga tgaccgttgt tggctatttc acgcataccg 248401 atgtattgaa ttatgagctt tcgatattga ttagttttgt cggggctttg ttaggtatgc 248461 tgatcagcta catgattggc agaaaagccg gacgcccgtt tatcgacaag tacggcaagt 248521 gggtcggctt aaaagaaaaa agaatgatga aagtggaaaa atggatgaag aaatacggtc 248581 catattctct tattttaggt tattttattc ccggcgtcag acatgtgacg tgctactttt 248641 cggggatcgg caaaatggat ctgaaaacgt atgttgcgtt tgctgcaatc ggcgcctttt 248701 tatggtgctt tgtttttatt acaatcggaa gggttatagg gattattcat gtttaatacg 248761 gctgtaaaga ttctgtatcg atcattgata gagctgacga atcatcgtct gtcatcctat 248821 ctgattaaag gattttgcga gtcgaaaatc agcaaaccgg tcattccgct tttctcaaaa 248881 cattttcggc tgaattggga tgatgtggac ggtacggctg ctgattacgg atcgctgtcc 248941 gaattgttca ttcgacaaat aaatctggag cggcgccctg tgtcaaaaga ggcgcatgcg 249001 gtggtcagcc ctgttgacgg tgtggttcag acggtaggaa tcatcaaccc gaatcaaacc 249061 tttacggtga agggaaaaga ttactcattc gctgagctga ccggctgtaa aagcgcagac 249121 catcaataca acggcggata tttcgtcgtg ctgtatttaa gcccgaggca ttatcaccgt 249181 ttccattctc cgatcagctg caggtatcaa aagctggccg agctcggaaa tcgctcatac 249241 ccggtaaatc aactaggctt aaaatacggg aaagatgtgc tgtcgaaaaa ttatcggttt 249301 gtgtacgagc tgaatagcgg cagccgaaat gtcctgatga ttcctgtcgg cgcgatgaat 249361 attaattcta tcgtgcagac gaatacccgt actgaattgg agatcggcga ggagctggga 249421 tacttttcat ttggctcaac cgtcattttg gtttttgaaa aagacgcgtt ccagccgtcc 249481 gcccatttag cagaaggcca agaagtccaa gtcggagaac tgataggtta cgaagaataa 249541 aaagaggagc ttgcataaac gcagcgcctc tttttttgaa gaaaggtgag attcatggag 249601 aaacaaatca tcagctggat tacagattat cagaacaccg gagatgaagc cgtcctgcgg 249661 caagtgcgag aagtgtgctg gccgatcgtt gaagcggttt tgcaagagaa agtaatggat 249721 gatgaacaag cgaacaattt gcgcgaaaaa ggaatcgagc ggtttccatt catcatcagc 249781 aaataccaag cggatgtgca gcttccggtt gagacatttt tacaaaatac gtatcggttt 249841 tactttcatc aggtgatgag agaatccagc taaagcttct ttcaacagag aagctttttt 249901 ttgttggcag gaaaaggaaa ctttttctat atctatctcg taatgactag agaacctagc 249961 agaaaaggag agatagaatt gaaacgaatg atagtgagaa tgaccctgcc gctgctgatc 250021 gtttgtctgg cgttttcttc tttttcagcc tcagcccgtg ctgcttctga agaaaaatat 250081 tgggatcact ggattgaacg acatgcacag cctctggatg cttccaatgc ttcaaacaaa 250141 gaccttcgat ttctaaaaaa ggtgctgaag ggaaaacgaa tcgttcagtt aggagaaacc 250201 acacacggtg ctggcgaaat caatgccaca aaggtcagaa tgatcaaata cctccacgaa 250261 gagctgggat acgatgtatt ggcctttgaa tccggctttc ctgatacaaa tgcatcctac 250321 cttaatatgg accaattaac ccctaaaagc acgatgaaaa actccattta cgctgtatgg 250381 cacacagaag atgtcgtcga attgtttgat tacatgaaag agcaaaaaga gaaaggcgat 250441 ccgctgatcc ttaccggttt tgatattcaa agcatgaaga attcattcaa tgtagctgcg 250501 actcaatggg taaaagcggt ggaccctgag aaagcagagt tgctctccca atcagaaaat 250561 gatttttcaa cattagtgac agacagcaat acgtttgatg aattttcgca aaagaaggaa 250621 aagcttgtga aaaactatca gaagctgatc aagttcacta aaacacatgc ttcagagcta 250681 aaagaaaacc ttccaaaaga gccgaaagct tatgagatgt ttatgcattc tcttcagctg 250741 agaattgacg taatggaaac atatatgctg gaagaaatga aagaaaaact agaggagtat 250801 ccggagaata ttgaggattt ttcattcttt atgagagacc gcatgatggc tgaacaattt 250861 cagtgggtag ccgacaccct ttatccgaaa aagaaaatca ttgtctgggg ccacaattac 250921 catctacgca aacagaatac gaagatgata aaggactggg tacagctaaa cggccctaac 250981 atgggtgatt atttgccgga gcggctgaaa aaacaaacat atacgattgg catttatgct 251041 tactcaggtg cgagtcttga tagctccgat aataagactg ttaagccggt tacaagcccg 251101 ccgccgtctg ggagccttga agctttgctg aaagcggcgg accgaccggc tgtttttgtt 251161 gattttctcc atacaaaaaa caagaaaggc acttcgtgga tgtatacccc gcggactgcg 251221 ctctattggg ggtacatgga agagcagatg atcctgaagg aacaatatga cggtgtcatt 251281 tggctggagc atatcacgcc ctctgtcatt atcaagtgag cggtgtcccc tgtggtaaac 251341 aggggatttt tacatatcgc aaaaataatc aaaacatata atccgtgatc cattattcta 251401 aaacagaaag gagattggag cgtgcaatgt attatgaaaa agctgtccag aaaacaatca 251461 attggattga atcacattta catgagcaaa tatcaaacga ggatattgtt aacgtttcaa 251521 gcttttcaaa attccatttt catcggattt ttcaaaaaga agtcggcatg tcggttgctt 251581 cttatattcg gttaagacgt cttgcgaatg cggcggcagc tttgctttat acagatcatc 251641 gtattatcga tattgctttg tattatcagt ttgaatctca agaagcattt acgaggacgt 251701 tcaaaaagat gtatcacatg ccgccaggag cataccgaac atttatgaaa cgctttactt 251761 caaaaaagga ggaatcttac atggagaaaa aaatgaaagg ctgggtattg agcgggagcc 251821 atccgttcca attcgaaatg gggattgacc gggaaaatgt acatcaggga aaagcttcag 251881 ggtatttaaa gtcaacgatg gttcaggata tcggtgaatt tgcgacgatg atgcagcaat 251941 tcaaagcaga tcgctatcta ggaaaaaggc ttcgtctatc aagttttatc aaaacaaagg 252001 gggtgcagca ttttgcctca ctttggatgc gggttgacag tgctgctgat gatgttctcc 252061 aatttgataa tatgagcaac agacctatta ccggaacaac caattggaat cattatgcta 252121 tcgttttaga tgtcccagaa aatagcgctg tgatatcttt tggcgttcaa ttatctgggc 252181 cgggtcaggt gtggatggat catgttgttt ttgaagaggt agatgagagc gttccttcaa 252241 caaaccttga aatgccggga gaacttttag atgaaccggt aaatttatct tttgaagagg 252301 aactacaaaa atagttttca gacaactact tttattagtg agttaatgga aaatactatt 252361 tgttattaat aaacccttgt gctgcttagg tttgtaagag cttggatatt tttatcagtc 252421 tgggcggatc tgttcatctt tgcggcattt tcctgtatga tatagtaaga gtgtgcatag 252481 caactaacta taattgaaca gggtgtttaa aacatggaaa aacaatacag agtattactt 252541 tactataaat atgttccgat tgaagatcca gaggcgttta gagagcagca tctggctttt 252601 tgtaaggagc ttggtttgtt aggccgtatc cttgtttctt ctgaaggaat taacggtacg 252661 gtatcaggta cggttgaaca gactgaaaaa tatatggaaa caatgaaagc tgatcctcgc 252721 tttgcggaca tggtatttaa aattgatgaa gcagaaggcc atgccttcaa aaaaatcttc 252781 gtccgccata aaaaagagct tgtaacgctt cgtcttgaag atgatgtcga tccgaacgaa 252841 acaacaggcc agcatttgaa gcctgcagaa ttttatgaga agatgcagga tccaaacaca 252901 attgtcatcg acgcgcgtaa cgattacgag tatgaccttg gccatttcag aggtgcggtc 252961 cgtcctgaca tcgaagcctt ccgtgaatta cctgaatgga ttgaagagca caaagatatg 253021 cttgaaggca aaaagatttt aacgtactgt acaggcggcg tgcgctgtga aaagttctca 253081 ggatggctgg tgaagcaagg ctttgaagat gtagctcagc ttgatggcgg aatcgtgaca 253141 tacggaaaag atccagaggt gcaaggcaag ctttgggacg gccagtgcta cgtatttgat 253201 gaaagaatca gcgtgcctgt caaccgtgtc gagcatgtga ttgtcggcaa ggactacttt 253261 acaggagaac cgtgtgagcg ttatgtgaac tgcgcaaatc catcttgcaa taaaaaaatg 253321 atatgcacac cggaaaatga gtataaatat atgcgcagct gcagccacga atgccgcacg 253381 aacccaagaa acctgtatgt gaaagagcat aatatgacag aagaagaagt aaacgcaaga 253441 ctggcagcga ttgaaacaga agatcacgct gctgctgaat aaaaaaagaa cacctcgtat 253501 tgaggtgttc tttttttcta tatgctttca gtttggctgt ttgcggaaac ccattctttt 253561 tggcggaagg ccttttccca ttttgatacc acgatacagg cgatcgcatg tcccggtacg 253621 ttcacgcctg ttctcgccat gtccatgacg cggtcaacac ccgcgataat ggcaacgcct 253681 tcagccggca gtcctacagc attggcagtc gccagaagaa ctacaagcga tcctgagggt 253741 acagctgcaa tgcctttact ggtcatcaca agcacaagca tcatgagcag ctgctgggac 253801 aatgtcatgt ctacttgaaa ggcctgtgcg agaaagatac aagaaaccga taaatataag 253861 ctggagccgt cacagttcaa tgacaagccg gagggaacga caaatgatac cactcgtttg 253921 ggacagccgt atttctccat tctatccatc agctgaggga gaatggtttc agtgcttgtg 253981 gtggaaaatg caattaaaaa cagatcccat atcattttca atacttcgaa atacttaatc 254041 tgaaagatga gaccgacaag cggaaagagg acaaagagga tcaggaacag gccaaggaat 254101 acggtgccaa ccagcttaaa catagggagg aggagttcaa tgccatattg gcctacagaa 254161 gcagccatca gggctaacac gccgatagga gcagtgacca tgacgatttg cgtgagcttg 254221 aacataatct gagctgtaga ttcaaaaaac ttcattactg gttcagaagc tttgccgata 254281 ccagctgcgg cgacaccaaa taaaatggcg aagaaaataa cggcaagcaa atcatttctg 254341 gccatgacat caataatgtt tgtagggata atatccagga tcatttgctt gaaatcaaca 254401 actttgtctg tgtagccgga aagttcatga atatcttttt ttgccaaatg ggagaggtca 254461 agcccgacac ctggttttaa gacattcgct aataaaagtc caagccctaa taccaacgtt 254521 gtaatcactt cgaaccaaat gatcgtcttg atgccgagac tgcccatttt tttcatgctt 254581 ccgcttcctg cggctccaat gacaatggta gaaaatacaa tcggcacaac aatcatttta 254641 atcaggcgga taaatccatc tccgacaggc ctcagtgcca tcccgaaatc aggaaaaaag 254701 tggccgatca ccgcgccgac agccaaagcg attaaaattt gaaacgcgat taattttttc 254761 aaatgaatcc ccctttagaa cgatagaatg taggcatatt catatcattc gtgattcaaa 254821 tgcaaacacc ttttttcaag ttattttatt ttgacagcgc tttcattatg ttggcgaaaa 254881 agtcccccgc agcagggggg acttttttac ttcatttgaa tgtgctttag atcttcttca 254941 gaggtatttg tgaaaataac cggtgttatg gctgaagcgg catgctgctt gatgtaattg 255001 agatcaaagg tgagaagcag ttcgccttgt ttgacggctt gtccgcttgt gacatgtgct 255061 tcaaagcctt ccccattcag tttgacggta tcgatgccga catgaatcag gatttcagtg 255121 ccgccggcgc tcataaagcc gatggcgtgt tttgtcggaa aaatcgagac gatctcgccg 255181 tccgcaggtg caacgacttt tccttctgat ggtataatcg caaatccctc gcccatcatt 255241 ttttctgaaa agacctgatc aggcacatcc cctaaagaga ctgtttctcc tttaatcgga 255301 taaataaagg tctcatcgga atcgggcttc agcggtttgt cagttaccgt gtccagcgcg 255361 gcggcggtgg cagggacgcc tccggccatg attgttttga tgtcgtcttt taaggcatcg 255421 gacttggttc cgaatattgc ctggaagttg ttgttgacct ccagcacacc tactgcacca 255481 agccgtttta attcatcctt gcagacttgg cttggctgat gaacggtcac acgaagcctt 255541 gtgatacatg catccaggtt agcgatattt tgctgtccgc ccaaggcctg cagcacgtga 255601 aaggcaagct ggtcttttgc aactggagct ttctcctcat tctgaccgtc ttcatctgtc 255661 tcacggccgg gcgttttcaa attccatttc agaatcgcaa atcggaacaa ataataataa 255721 atgaaagcaa acacgatccc gacaggaatg acaacccagc cgtttgtaga cagtccgtag 255781 ttcaagacgt agtcaattcc tccgcctgag aacgtatagc cgtggcggac atggaataaa 255841 tcacaaacga caaagatgac gccggcaaga atagagttaa tcaaatagag cacgggcgca 255901 acgaacaaga aagaaaactc aaccggttct gtaattccgg tcagcataga tgtgagcgcc 255961 gcagaaatca tcacgccgga gatcattttt ttcttttccg gacgcgcggt atggataatg 256021 gcaagagcaa cggccggcag acagaaaatc atgtaaggga aatcccccat cataaagcgc 256081 ccggctgtcg ggtctcccgc gaaaaacctt gtcaggtcgc cggttacggt gttgcctgtt 256141 gatgggtctg tgtattctcc catcataaaa tagaaaggcg tataaaaaat atgatgcagg 256201 ccaaaaggaa tcagcaaacg atagatcgtt gcataaaaga acaggccgac tgttgaatcg 256261 gcaattaaac tgctggctgc gttaattccg ttttggatca gcggccaaac gaatgagaaa 256321 atgacgccga tcaccaatga actgacggaa gtaatgatcg ggacaaagcg ttttccagag 256381 aaaaatccaa ggaccggatg cagctcgatt gatgaaaatc gcttatataa ataggcggcg 256441 agaagcccga taatgattcc tccgaaaacc cccatatcaa tcaggtgctc ggctccttca 256501 tacggaggct gaaggccgag taattttccc atattgtcga gggtgacggt taaaattaag 256561 tatccgatga cagcggcaag tccggctaca ccttctccgc cggctaatcc gatcgcgacc 256621 cccacggcga aaatcagcgg aaggttatcg aatacaacgc cgcccgcatc ctttataata 256681 gggatgttca gtaaatcctt gtctccgaaa cggagcaaaa gacctgctgc cggcaggacg 256741 gcaaccggag tcatcaacgc gcggccaagc tgctgcagaa tttgaaatgc ctttttaaac 256801 atgacagtct ccttttattg tgttatgaga atgatgcact ctttaatttt tgagctgctt 256861 tataatcggc gataacggtt acatgattgt gtttttgaag aatggaggct ggtacatctg 256921 tcgtgacagg accttcagcc atcttttgaa tggcgtctgc tttttcctcg ccgcttgcta 256981 aaagcacaat atgtttgctg aattccatga tggttttaat gcccattgaa atcgcgagtc 257041 tcggaaccag caccggatcg ccgccgaaga atctggcatt tgcctgtatc gtgctttccg 257101 agagcttcac aacacgtgtc cggtcttcaa aatcagatcc cggttcatta aaaccgatat 257161 ggccattggc gccgatgccg agaatttgga catcaatgcc tcccgcctgg cggatgagat 257221 cctcgtatac tttgcatgcc gcctcaagct gcggattgtc tccttgcggg atatgaatat 257281 gatcaggctg catattgata tgctgaaaaa gatgctcatg cataaaatgg ttataacttt 257341 gcggatgaga tggagagaga ccagcatatt catccaaatt aaatgtagta acctttgaaa 257401 aatcaatttc gcctgcctga tagtctgaaa tcaactgctt atacaagccg accggtgtgc 257461 ttcctgttgc caggccgaga acggcatctt tcttagcttg tatttgttct ttaataatgg 257521 cagcgcttaa cttacagagt tcttcgtagt gctcggcgat cagaatcttc atgtgacacc 257581 ccctcaaaga gatagacaag caccatattt gttatgacca atttatgata cttgtcatta 257641 cgaatttagc accgccctta tcaaactgtc aatattaatt tctgaaaatt tgttataaaa 257701 gaaggataca aatctttcat attgggaggg caaatggtat tatggtctca atgaaaaaga 257761 acggattgca tacagaatgg ggagaatgaa atgacagctt tatattctgt tatcaagttt 257821 aaaatcattg agttaattaa atcgggcaaa tatcaggcga atgatcagct gccgacggag 257881 agtgagtttt gcgaacaata tgatgtcagc agaacaactg tgagactggc tctgcagcag 257941 ctagagcttg agggatatat taaaagaatt caaggaaaag ggacatttgt atcggcggcc 258001 aaaatacaaa cgccgattcc gcataagatt acgagctttg cagaacaaat gagaggactt 258061 cgttctgaat caaaagtgct tgagcttgtg gtgattcctg ccgatcattc catcgccgag 258121 cttttgaaaa tgaaagagaa tgaacctgtc aacaagcttg tcagagtcag atacgccgag 258181 ggggaacctt tgcagtatca tacctcatat attccctgga aggcggcacc ggggctggcg 258241 caggaggaat gcaccggctc gctgtttgaa ttgttaagga caaaatacaa tattgaaatc 258301 agcaggggca cggaatcgat cgaaccgatt ttaacggatg aaacgatcag cggacactta 258361 ttaaccaatg tcggagcgcc tgcgttttta tcagaatccc ttacctatga taaaaatgaa 258421 gaagtggtgg aatatgcgca aattattaca cggggagacc gaacgaaatt caccgtagaa 258481 cagtcatatc attcataaag caatgtgttt taagaaggga atggtggttc tatgttttta 258541 tttacgaatg gaaaagtgct gtggggagca gtgattgctg cattcatcct ttcaattgta 258601 ttttaccctt ttctgccgac gcagatgccg attcattatg atgttgcgaa cagtccggat 258661 ctgacggtta acaagctggc ggggactgtg atgctgcctg ttttgatggt ggtgtttgca 258721 tgggcgcgga agatcaattg gcaatttgta ttcgcagtgt atattttgct gatttgccac 258781 attgtcgtcc tttgtttagc gctctaaatc aaacagccag aataaaactg gctgttttct 258841 ttaatttcag cttcatctga caatgaatgt ggtgtataat agctgatgat cctaaagaat 258901 attctgaaat ttataggtgt gaagcggcgt attattaaag gaaaggctgt atactttttg 258961 cagctttaaa aagactgaat atttaaacaa ttatgtgaaa ggtgtgctga ttagattgaa 259021 taagcttatt gaacgagaaa aaactgtata ttataaggaa aagcccgacc cgtcttcctt 259081 ggggtttgga caatatttta cagattatat gtttgtgatg gactacgaag aggggattgg 259141 atggcatcat ccgagaattg cgccgtacgc accgcttacg cttgatccgt cttcatctgt 259201 ttttcattac ggccaggctg tttttgaagg attaaaagca tacagaacag acgacggcag 259261 ggtgctgctg ttccgtccgg atcaaaatat caaacggctg aacagatcgt gtgagcgcat 259321 gagcatgccc cctttagacg aagagctggt gcttgaggca ttgacgcaat tagttgagct 259381 ggagaaagat tgggttccaa aggaaaaagg aacgtcactg tatattcgtc cttttgtcat 259441 tgccacagaa ccgagtctcg gtgtgaaggc atccaggagc tatacattta tgatcgtgct 259501 ttcgcctgtc ggctcctatt atggcgacga tcagctgaag ccggttagaa tctatgtcga 259561 agatgagtat gtgagggcgg tcaacggagg agtcgggttt gcaaaaacgg ctggaaacta 259621 tgccgccagt cttcaggcac agcggaaagc gaatgaactg ggctatgacc aggtactgtg 259681 gctggacgcc atcgaaaaga aatatgtgga agaagtaggg agcatgaaca tctttttcgt 259741 cataaacggg gaagctgtca cacctgcttt aagcggaagc attttaagcg gggttacacg 259801 tgcgtctgcg attgaattga ttcgaagctg gggcattccg gttcgtgaag agagaatatc 259861 gattgatgag gtgtatgcgg cctctgcacg cggagaattg acagaggtct ttggcacagg 259921 cacggcagca gtcgttacgc ctgtcggtga actcaacatc catggaaaaa cggtgattgt 259981 aggcgacggg caaatcgggg acctctcgaa aaagctgtat gaaacgataa cagatattca 260041 gcttggcaag gtaaaaggcc cgtttaactg gacagtggaa gtgtgaaaat cgaaaaagaa 260101 cctgcccgga ggcaggttct ttttattttg aatgagtcat atcagcagcc ggctggcttt 260161 tgcggttttt tacataatat attgcatagc aaatggccat aaatggaacg ccgcaataga 260221 gtgcgattct ttgattcgga tcaaaggcaa tgccaacgac ggaagccagg cataacagga 260281 acgcagcaat cggcacgaac ggatacaaag gggttctgta tttcaaatca gtaaccttgt 260341 ttcccgcttc gatataacgt tttctgaaca tgaattgaga agcagcgatt cccatccaca 260401 cgacaacgac ggcaaaaccg gaaatcgaca cgagcacaac gtatacagtg tctggcgcaa 260461 atacgctgga cagcaacgac agaatgccgc cgatcatgct gaacaccagc gcgttaaaag 260521 gggttccttt tgacgtcagc tttgcaaatg tcggatgaag cgttttttct tttgataaag 260581 accacagcat ccgggaagaa gcgtagagtc cggaattagc cgctgacagg atcgctgtca 260641 ggataacaaa gttcatgata tcggctgcgt atggtacacc gactctgtca aagacagcga 260701 caaacgggct tttgatgaca cctgcatctt gaatcggaat cagccctgac agcacaaaaa 260761 ttgttccgac aaagaagagc gagagacgcc agaccgttgt ttttatcgct tttggtatcg 260821 tcttgtcagg atcaacgctt tcaccggctg cgattccgat tagttccgtt cccgaaaagg 260881 caaaattgac ggacagcatc gtcatcaaaa tcgggacaaa tccattggga aaaagcccgc 260941 cttccgccgt gaagttggac agcatcggag cggcttctcc gcctttgatc gggatgatgc 261001 cgaacatggc agagccgcct aaaagaataa ataatacaat ggctaatact ttgatgctgg 261061 aaaaccaaaa ttctgattca gcgaaaaact tgaccgaaaa tgcgttaagc aagaagatga 261121 acagcgcaaa gacggcactc cacatccaaa ccgatgtatg ggggaaccag cgctgcatta 261181 acaggccggc tgctgtgaat tctgatccca atgccacggt ccatgtcagc caatacagcc 261241 aagcgaccgt aaatccggtg cccggcccta tgtatttggc tgcataggtg tgaaaggcgc 261301 cggtcacagg catggcgact gacagctcac cgaggcatag catgaccaga tagacgatgc 261361 cggccccgac taagtaggcg agtatcgttc cggccgggcc tgcttgctga atggtataac 261421 ctgagcttaa aaacagcccg gttccgatga cacctcccaa ggaaagcata aagaggtgcc 261481 ggcttttcat acttctctga aaggttgtct cattcttgtt gtgggcagag ttcatctttt 261541 tccaactttc tatcagcgat ttatttcctt cctaataaaa aatctcatgt cagaaagtga 261601 cacgagactc cggcgaaccg gctttaagtt agaatataca aactattccg ataagtcaag 261661 ttgtttttaa agagcgggcc caagccgcaa tttcttgaat attttcgggt tttgtccggc 261721 agcagccgcc aatcagcctc gctccttttt catgccaggt gcgggcgctc gccccgtaag 261781 attctgcgca tgctgcgccg ttccacgttt ttgtttccgg atcatattgc tcacctgaat 261841 tcgggtagac aatgatcggt tttgacgtgt tcttttttaa ctcctctatc aaggaaggga 261901 tatgctgaag cggcgtgcag ttgatgccga gtgctgcaat ttggcggtgt tcatcaagcc 261961 acgatgcgca gtcagctgca ggtgttccgt cactgatatg caagccgtct ttagcactga 262021 agctgatcca tgcatacgtt tcaggaaatt ccttcaacag ccgaacaatc gctttggctt 262081 cagtcagaca cggaatcgtt tcgcatgcca atacatcagc tccggcttca atcagcgcct 262141 tcatccgggg gcgatgaaat tcaatcagtt catcttctga tattgcgtag ttgccgcgat 262201 actcagaccc gtctgcaaga taagcgccat aagggcctat agaagccgca atgatcggtt 262261 ttggccgatt caaacggttc tcttcaagcg accaaaattc atcacgtgct tcagctgcga 262321 tgctgacgga caactcgatg agccggcgtg cttccgcttc gctcagcccg cgtgcggcaa 262381 agccttcaaa tgtagactga tagctggcgg tgattgcaca atcggcgcct gccgcaaaat 262441 aatcagtatg aacttgttta atcagctccg gctcttccat caggattttt gccgaccaca 262501 gactgtcatt caaattacag cccttgcgtt caagctcggt cgccatggcg ccgtctagca 262561 caataagcgg gtatgtatct aatatgtgtt ggataggatt catagaatgt accgatgcct 262621 tctttcagat ttttttgaaa aagatatgaa aatcgtaatg gaggcttacg tgtttgtcaa 262681 taaacgcaaa aagagaaagg tgttcagccc atatgtctga acaccctttt cttatgatat 262741 ttgtttgttg tgcgtgtcag tctttgtgtc tgaaaccggc cagcactcaa tgccattatg 262801 gtttttgagc acatctttat aaaagaccgg atccttgcct gcttttttct ggcgtgtata 262861 gtctttcagc gccgtaaaaa cgacctttga tagtaagaaa atcgcgatta aattcacgat 262921 gaccatcaaa cccatgaaca aatcagcaag atcccagacg agctggactt tggcaacaca 262981 gccaaacacg atcattgcca gcacgccgat acggtagaca aaaatcagtt ttttgctttt 263041 gttcaaaaag ccgatattgg tttcgccata ataatagttt ccaattagag cacagaatcc 263101 gaataacaaa atcagaatcg cgagaaagcc tgatgcccat gatccgacat gggagctgag 263161 ggaggcttgt gtcaaggcga ttccgctcag acccggagta tgataggcat ccgaaaacag 263221 aatgataaaa gcggtgcttg tacaaatgac cagtgtatct gtcagtacac caaaagcttg 263281 gatcagcccc tgtttgacgg gatggcttgt tgtggcggtg gcagcggcat ttggtgcgct 263341 tcccattccc gcttcgtttg aaaagattcc ccgtctgacg ccttgcatga gtgccgcgcc 263401 caaagccccg ccggcggcct ggtcaaaacc aaacgcattt ttcacgatta gcgcaagcac 263461 acctggcagc tgcgtaatgt tggagaaaat gacgaaaaac gcaactccga tatacaggac 263521 agccaatacg acgacaatgg attcagccag ctttgcaatg cgcttgactc cgccaaaaat 263581 aatcgtgccg aatacagcaa ttaaaatgag tcccaatgtc aggcggtttg tgccaaacgc 263641 gttttcaaag gcaaggctga ctgtattgga ttgaaccgag ttgaagacga taccgaacga 263701 taaggtgatt aacacagcga acagcgcgcc catccacctt ttgttcagcc ctttttccat 263761 gtaatacgcc ggcccgccgc ggaagccgtt tacatctttt actttataaa tctgagccag 263821 tgtgctttcc acaaagctgg atgctgatcc gataatggcg ataatccaca tccagaagat 263881 tgcaccgggc ccgccgagtg caatggcgat agcaatgccc gtaatatttc ccgttccgac 263941 acgggccgcc atgctgatgc aaaaggcttg aaacggagaa atgctgtttt ttgaccggga 264001 agcagcacct tctcttaata ccctgaccat ttctttcagc atgcgaacct gtaaaaactt 264061 aagcctgaac gtaaaataga ttccaaaaga aaggagcaaa acaattaata gctttgacca 264121 caaaagatca tttgcaatac cgacgatatg ttctaggatt tgctgcatag aatcacctct 264181 tttttcatgt ttaaaaaatg ctgagctccc attcctgcgc catatgcttc agcagcatac 264241 cgccagtgag gctgttgccg tattcatcaa tggcaggccc gtaaatgccg atgccgcatc 264301 cggattgaaa aggctgttct cttctggcgc ttggaggcac cagcgccatg atgccgccgg 264361 agacgccgct tttggccggc acgccgacaa acgccgcata tttgcctgaa gcgttgtaca 264421 tgccgcacgt cagcattaat gccttggcca attttgccac atcttttgga atcacctgct 264481 cgtgtcgaat cggatgatac ccgtcatgag caaggatcag gccgatcaac gcaatatctt 264541 ctgtagtgct ctccatagcg cattgcttca agtacacctc aagtgtttct tctacttcag 264601 cttctaaaaa gtttgtttct tttaaatagt aggccagcgc tctgttgcgg tgggcggttt 264661 cccattcaga acggaatact tcttcatgaa ttcttggccg ttttcctatc aaagtttcca 264721 tcaccgagta aagaaactcg agcttttcgt atgcagattc tccgggaagg atcgaagcga 264781 tggtgagggc acccgcgttg atcatgggat tgaagggctt tcccggcttg ttgatttcga 264841 gccgaatgat tgaattaaag gcgtcacctg tcggctcgac atctacgcgg tcaagcacat 264901 agggaatgcc gcggctcatg caggcggcaa taaagctaat cacttttgaa atgctttgca 264961 tggtaaaaga gacgttccag tcgccggcgt gtatcatcgt tccatcaggc tccaatacac 265021 agatgccgag ctgtgaatca ttgacttttc ctaaagcggg gatatagttt gcgctttgtc 265081 cattggcggc aaaagggcga tagtattcaa cccaatcatg aagctgtaac gccgggttta 265141 tgtctttctg gtgctctttt atcaattctt tcatcgaatt cctcctcact gatttttttc 265201 ttaaaggact gaggtgtatc aaaacgaagg ctaagggggc gttaaacgct ttcataatag 265261 cggaaggtat aattactgta taatggagac tacagaatca tacaaaatac gacaaaaaca 265321 ttttgaaaat aagcagtaag atttataaaa acctcatgtt ctgggtcaaa agcaatttgc 265381 aggttttctc ccgattcccc aaaataaaaa gcgaggatgt gatcaacata aaactggaac 265441 ggtttattga aaaagacgga tatatactgg ccctcatgct gattacggtg ccgctggccg 265501 gtgaactgaa attttatccc ctcaatgaag aattccgggt cagctttggg gcaccggttt 265561 ttttcttctt tttatcattg ttgcggcatg tgcccgctgt gctgccgggt tttctgactg 265621 gagcggctgt tttcatcttt cgcgtctttc tggaattatg gggcggagga cacaatgggc 265681 tgactccgat tctgtatgat caagcgtctg gctttttctt ttatatgact tacgcctgtc 265741 tgttttccat attaaaggcc aatcgtttcc gtgaacggcc gattatgctc ggtttcattg 265801 ggtttatgat tgaagttgtg tcagattgtg tcgagctaac tgtgcaattt ctcatttttc 265861 atacggttgt cacgcctgag aaaatcactg acattgcggt gattgcgatt tctcacacat 265921 ttattgtgat gagcttttat agtgtgctga agctgtatga aacacaatcg agagaaaaac 265981 agacaaggca gcagcacgag cacatgctga tgatcgtttc caatttatat gaagaaacgg 266041 tgcacctaaa aaagacattg aaaacgacag agaaagtgac aaacgattcg tatcagctct 266101 atcgggaaat gaagggcaag gatgttcagc tgagcggcag aatcctgaga ctggccggag 266161 agattcatga agtgaaaaag gacaaccagc ggatattcgc agggctttca aaactgattt 266221 cgaatgagag tttgagagat tatatgaggg cttctgattt gctgcagctc gtgattcgaa 266281 tgaatgaaaa gtacgctgaa gcactaggga agcagattga tttttactgc tcgatcgagg 266341 gagagcatga cgaatatcac gtatttatcg tgctttcgat cattaataat ctaacagcaa 266401 atgcggtaga ggctatggat gaagagggaa tggtcagcct gaggctccgt aagccaaatg 266461 agagtatggt agaattccag gtggaagaca atggccccgg gatttccgag aaaatcggag 266521 acattgtgtt tgacccgggc tttacttcaa aatatgacga atttggcacg ccttctacgg 266581 gtatcggact ttcctacgta aaggaaatcg tgacagagct agaaggggat atcacgtttg 266641 ataatcagca gcggggagtg gtgtttgcca tcaggctgcc tgtccggcat ttgattcaga 266701 aagggtgaac caaaagctat gcgttttttt attgcagatg atgaccgtgc ggtgcggtca 266761 attttaaggc agatcattga ggacgaagat ctcggggaag ctgctggtga agcagacgac 266821 ggaagccaag tggaagggca tatgctgcaa tttaagcaga ttgatatttt attaatcgat 266881 ctgttaatgc ccggaagaga cggcattgag acgattcgtc agatccagaa tacgtactcc 266941 ggcaaaatcg taatgatctc tcaagtggag gcgaaggaaa tggtcgggga agcgtactcg 267001 ctcggcatcg aatattttat ccataagccg attaaccgca ttgaaattgt cacggttctc 267061 caaaaggtga aggagcggat cgagcttgaa cactcgattg gagccattca gcattctcta 267121 agccggcttg tcaatcggac tgaacggaaa gcgcgtcccc agcagaagag tgacagcggt 267181 ttaaaagagg caggaacatt cctgttgtcc gagctgggca tgatgggaga aggcggcgca 267241 catgatctca tggcggtcct gcagtattta gcagaacacg agcaatccga gccgcacgaa 267301 aaacaaagcc cttcgctaaa acaaatattc acccaagtag cggtacggaa gctggggaca 267361 ggagcctcac agacggaagt caatcgcgaa atgaaagcct cggagcagcg tatccgcaga 267421 gcgattattc attcgctgca ccattttgct tcactgggca caactgattt ttcgaatcca 267481 aaatttgaaa cctatgcatc gaaattcttt gattttccgg ttgtcagcca gaaaatgaaa 267541 gaactccaat ccaaggatgc aaaacccctt gcacctgcta gaataaatat gaaaaaattc 267601 atccacgtgt tttttttgga agcaaagctt ttgcatgaga cgatgaaaca aagaaggata 267661 taaaccaaac agccggctga ccaggctgtt tttttgctgc gcagaatccc ggccggacag 267721 tgatttaccg cttttttata aaatatcaga aaataaagat attgacttat tgtttatttg 267781 tcttacaatt aaacaaaagg atatatggga aggagcggat gtgaaagaaa aattaataaa 267841 agcgcttaca gatagaggcc gtatacacaa ataacaggag gttatgttga tgagccgtat 267901 cagaaaagca cccgctggaa ttttaggttt tccggttgct ccttttaaca cacaaggaaa 267961 actggaggaa gaagctcttt ttcaaaacat tgagtttttg ctgaatgagg gcttggaagc 268021 gatatttatc gcttgcgggt ctggtgaatt ccaatctctc agccagaagg aatatgagca 268081 aatggtggaa gtcgcagtct cggcagccgg aggaaaggtg ccggtctaca cgggggtggg 268141 cggcaacctc agcacagcgc ttgattgggc gcagctgtcg gagaaaaaag gcgccgacgg 268201 ctacttgatt ctgcctccgt atttggtgca tggcgaacag gaggggctgt accagtatgc 268261 gaaaacgatt attgaaagca ctgacttgaa cgcgattctt tatcagcgcg ataacgcagt 268321 tctctctgtt gaacagatca aacgtctgac cgaatgtgaa cagcttgtcg gtgtcaaaga 268381 cggggtagga aatatggatt tgaatatcaa tctcgtctat acgatcggcg accgcttggg 268441 atggctcaac ggaatgccga tggctgaagt gacgatgccg gcttatctgc cgatcgggtt 268501 ccactcttac tcttcagcga tttcaaatta tatcccgcat atttcgcgaa tgttctatga 268561 tgcattgaaa aacggaaatg acgagcttgt gaaggaactc tatcggcatg tgattctgcc 268621 gatcaacgac attcgcaaac aacgaaaagg ctacgccgta tccttgatta aagccggtat 268681 ggaaatcatg ggtttgaatg taaggaatac agccagaccg cctgtcggcc cggttgaaaa 268741 agatcattat cagcaattgg aagcaatttt gaagcaggcg gctgaccgtt ttccgaaaaa 268801 agccgcgacg gtttgaccag aaaaaacacg aaaggggcaa tgggcatgtc tgtgatcacg 268861 gaacaaaaca cgtacctcaa ctttattaac ggagagtggg ttaagtctca atcaggcgat 268921 atggtcaaag tcgaaaaccc tgccgatgtg aatgatattg tcggatatgt acagaattca 268981 acggctgaag atgtggaacg tgccgtcacc gccgccaatg aagccaaaac ggcttggaga 269041 aagctgacgg gtgccgagcg cggccaatac ttatacaaaa cagcggatat catggagcag 269101 cgcttggagg aaatcgccgc ctgtgcaacg cgtgaaatgg gtaaaacatt gccggaagcg 269161 aagggagaaa cagcccgggg gattgccatt ctgcgctatt acgccggaga gggcatgcga 269221 aaaacgggtg acgtcattcc gtctactgac aaagacgcgc tcatgtttac cacccgtgtt 269281 ccgctcggtg tggtcggtgt gatttctccg tggaacttcc cagtggcgat tccgatttgg 269341 aaaatggcgc cggcattggt atacggcaat accgttgtca tcaaaccggc gacagaaaca 269401 gctgtgacat gcgcgaagat cattgcctgc tttgaggaag cggggctccc ggcaggggtc 269461 atcaatttgg tgacaggccc gggttctgtt gtcgggcagg ggcttgctga gcatgacggt 269521 gtaaacgccg ttacgtttac cggttcaaat caagtcggaa aaatcatcgg gcaagccgct 269581 ttagcgaggg gagccaaata tcagcttgag atgggcggca aaaaccctgt catcgtagct 269641 gatgacgctg accttgaagc tgcggcagaa gctgtcataa cgggggcctt ccgttcaacc 269701 ggccagaaat gcaccgcgac aagccgtgtc atcgtacaaa gcggaattta cgagcgcttt 269761 aaagaaaaac tgctccagcg cacaaaagat attacaatcg gagacagctt aaaagaggat 269821 gtctggatgg gaccgatagc cagcaagaat cagcttgata actgcctgtc atacattgag 269881 aaaggcaaac aggagggcgc ttccctttta ataggaggag aaaagctgga gaacggaaag 269941 tatcaaaacg gctattatgt tcagcctgcc atctttgaca atgtgacatc tgagatgaca 270001 attgcccagg aggaaatttt cggtccggtg atcgccttga tcaaggtgga ctcgatagag 270061 gaggcgctga acatcgccaa tgatgtgaag ttcggtttaa gtgcatccat cttcacggaa 270121 aacatcggcc gaatgctttc tttcattgat gaaatcgatg ccgggctggt tcggatcaat 270181 gcagaaagcg caggtgttga gctgcaggcg ccttttggcg gcatgaagca gtcgagctcc 270241 cactcccgag aacagggtga ggcagcgaag gactttttca cagcgatcaa aactgttttt 270301 gtgaagccgt aatggtgctg gaaagaggcg tgcgtctctt tcccggttta tcacaaccag 270361 catatgattc tctactttga aaaggagaag atactatgaa aaaagacttt gcgagtgtta 270421 ctccggcggg caaaaaaacg tccgtgcgct ggttcatcgt gtttatgctg tttcttgtga 270481 cctctattaa ctacgcggat cgagcgacgc tttccatcac cggagattcc gtccagcacg 270541 atttgggatt ggactcggtc gccatgggat atgtcttttc tgcctttggc tgggcctatg 270601 tcatcggaca gcttccgggc ggctggctgc tggaccgttt tggttcaaag actatcattg 270661 cgttaagcat ctttttctgg tcgtttttta cgttgctgca aggggcgatt ggctttttct 270721 ccgccggcac agcgattatc ctgctgtttg cactgcgttt tctggttggt ttatcagaag 270781 cgccttcatt tcccggaaac ggcagagttg ttgcctcatg gtttccaagc tccgagcgcg 270841 ggacagcttc agcctttttt aattcagcac aatacttcgc aatcgtcatt ttttctcctt 270901 taatgggctg gcttacccac tctttcggct ggcattccgt tttcgttgtc atgggtattg 270961 caggcattct tctggctgtc atctggctaa aaacggtgta tgaaccgaaa aaacatccga 271021 aggttaatga agctgagctt gcgtacatcg aacagggcgg cgggctgatt tccatggatg 271081 acagtaaaag caaacaagaa acagaatcga aatggccgta tatcaaacag ctgttaacga 271141 accgcatgct gattggcgtg tacatcgcgc aatactgtat tacgactctc acctatttct 271201 ttctcacatg gtttccggta tatttggttc aggcccgcgg catgtctatt cttgaagctg 271261 ggtttgtcgc ttccctgccg gcgctgtgcg gatttgccgg cggcgtgctt gggggcattg 271321 tgtcagacat cttactcaaa aaaggccgtt cactgacctt tgcaagaaaa gtgccaatca 271381 ttgccggcat gctgctgtct tgcagtatga ttgtctgtaa ctacacagat tcagcatggc 271441 tcgtcgttgt cattatgtcg ctcgcgtttt tcggaaaagg cttcggcgca ttgggttggg 271501 ctgtcgtgtc ggacacgtct ccgaaagaat gtgcaggatt aagcggcggt ttgttcaaca 271561 ctttcgggaa tattgcctca attacaacac cgattattat cggatacatt gtcaatgcca 271621 ctggatcttt caatggcgcg cttgtgtttg tcggcgctaa cgcgattgcg gcgatcctca 271681 gctatttgct gctggtcggg ccgatcaaac gggtcgtgtt aaagaaacaa gaacaagacc 271741 ccgatcaatc gttgcctgtc taatatttat gaaagcgctt tataaaggga ggaaaatgca 271801 tgagttcacc gatacaagag caggttcaaa aagaaaaaag atcgaatatt ccctcaattt 271861 ctgaaatgaa ggtgattcct gttgcgggac atgacagcat gctgctgaat ctaagcggag 271921 cacacagccc gttttttacc cggaatatcg taatcttaac agacagcagc ggaaatcagg 271981 gagtcggcga ggtgcctggc ggagagcata ttcgccgcac actggagctg tcagagccgc 272041 ttgttgtcgg aaaatctatc ggtgcgtacc aggcgatatt gcaaacggtc agaaagcagt 272101 ttggcgatca ggacagggga gggcgaggaa accagacgtt tgatttgcgc accactgtgc 272161 acgccgtcac cgcactggaa gcggctttgt tggatttgct tggaaagttt cttcaggaac 272221 cggtcgcggc tttgctgggc gaagggaagc agcgtgatga agtaaaaatg ctcggttacc 272281 tcttttacat cggcgaccga aatcggacga ccttgccgta tcaaagcgat gagcagtcag 272341 attgtgcgtg gttccgtctg cgccatgagg aagcgctgac gccggaggcc attgtgcgtc 272401 ttgccgaatc cgcacaggag cgctatggct ttcaggattt caaattgaaa ggcggggtgc 272461 tgcggggaga agaggaaatc gaagctgtta ccgcattatc gaaacgtttt ccagaggcaa 272521 ggatcactct tgatccgaac ggggcatggt cattagagga agctattgca ttatgcaaag 272581 gaaagcaaga tgtgctcgcg tatgcggaag atccatgcgg ggatgagaat ggctactccg 272641 ctcgtgaagt aatggctgaa ttccgccgcg cgacagggct tccgactgcg acaaatatga 272701 ttgcgactga ctggcgggaa atgggtcacg cgattcagct ccacgcggtc gatataccgc 272761 tggctgatcc gcatttttgg acgatgcaag ggtcggtgcg ggttgcgcaa atgtgccatg 272821 attggggttt gacatggggc tcgcactcca acaaccactt tgatatttcc cttgcgatgt 272881 ttacccatgt ggcagcagcg gctccggggc ggatcacggc gattgatacc cattggatct 272941 ggcaggacgg gcagcgatta acgaaacagc cttttgagat ttcttctggc tgtgtcaagg 273001 tgccggataa gcctggacta ggcgtcgata ttgatatgga acaagtggaa aaagcgcatg 273061 agatctatcg gaaaatgaat ttaggcgcac ggaatgatgc gatcccaatg cagttcctga 273121 tcagcaactg ggaatttgac cggaagcgcc cgtgtcttgt gcgataagtt tgattgtaaa 273181 tattgtcata tccgctattt tgtcttacaa ttgaacaact gaagggagag ttgttcgtgt 273241 acgaaggttt agaggatttg aaagtcgata cagtcaatcg gaaaacatta gccaagcagg 273301 tcatcgaacg gattgtccat ttattatcga gcggacagtt gagggccgga gacaaattgc 273361 cgacagaaat ggaactgatg gacattttgc atgtcagcag gccggtgcta cgggaagcac 273421 tcagttcact tgaaacgctg ggcgtcatta cgagaaaaac acgagggggc acatatttca 273481 acgataaaat cggcatgcag ccattttccg tcatgcttgc tttggccact gataatcttc 273541 cggctatcat tgaagcgcgg atggcgctag aactcgggct cgtgacaatt gccgcggaaa 273601 aaatcaatga ggaagagctt cagcgtttgc agaagacgat cgacgatatt gccaacagca 273661 ctgacaatca ttatggtgaa gcggataaag agttccatcg aattattgcg ttaagcgcca 273721 ataaccccgt cgttgaaggg atgattcagt ccctgctgat cacccatgcg aaaattgaca 273781 gccaaattcc gtacagggag agagatgtaa cggtcgaata tcacaaaaaa atctacgacg 273841 cccttgccaa aagagatccg tacaaagcac attaccacat gtatgagcat ctgaaatttg 273901 tccgtgacaa aattctaaaa ggaatggatg aaaaataatg gtgagcaacc gcagttgaaa 273961 cgtaagagct gcggtttttt taaaccaatt tagaaaacgc ttactaaaat atgaggagtg 274021 attttcatat ggcgatgaac ctcaggaaga accaagcccc cctttacatc aaagtgcatg 274081 aaatagataa caccgcgatt attgtaaatg atggagggct gccaaagggc actgttttct 274141 catgcgggct cgtacttgaa gaggatgttc ctcaaggcca taaggtggcc ctcaccgatc 274201 tcaatcaagg ggacgagatc gtgcgttacg gagaggtgat cggatttgct gatgagacga 274261 tcaaacgcgg gagctggata cgggaagccc tcgtgagaat gcccgctcct ccggcgttag 274321 acgatcttcc tctcgcaaac agggtgccgc agccgcggcc cccacttgaa ggatatacat 274381 ttgaaggata ccgaaatgcg gatggcagtg cggggacaaa aaatatcctc ggcatcacga 274441 caagtgttca atgtgttgtt ggcgttttgg attatgcagt caaacgaata aaagaagagc 274501 tgctgccgaa atacccaaat gtcgatgacg ttgtgccgct gcatcatcaa tacggatgcg 274561 gcgtggcgat caatgcgccc gacgctgtca ttccgatccg cacgattcaa aatcttgcga 274621 agcatccgaa cttcggcggt gaagtaatgg taatcggatt gggatgtgaa aagctcctcc 274681 cggaaagaat tgcctccgaa aatgatgatg acattctatc gctccaggat caccgaggtt 274741 ttgcggcgat gatccaatcc attttggaaa tggcggagga acggttaatc aggctgaaca 274801 gcagaacccg ggtgtcatgc cctgtttcgg atctggttat cggcctgcaa tgcggcggca 274861 gtgatgcgtt ttccggcgtg acggcgaacc ctgccgtggg gtatgcggct gatttattgg 274921 ttcgcgcagg tgcaacggtt ttgttttctg aagtgacaga ggtgcgggat gccattcatt 274981 tattaacgcc gcgggctgtc agtgaagagg tcggacaatc gctgatcaaa gagatgaagt 275041 ggtatgacag ctatcttcgg cggggagacg cagaccgtag cgcaaacccg tcaccaggca 275101 ataaaaaagg cggattatcc aatgtggtgg aaaaagcgtt aggttcggta gcgaaatcag 275161 gcacaagccc catctccggc gtgctcggcc ctggtgaaag agcaaagcaa aaaggcctgc 275221 tgttcgcggc gacaccggca agcgattttg tgtgcggcac cctgcagctg gctgcgggca 275281 tgaatttgca ggtgtttacg acagggagag gaacaccata tggcctggct gctgcgccgg 275341 ttctgaaagt atcgacgcgg cattccttat cagagcattg ggctgattta atcgatatca 275401 atgccggccg aatcgcgaca ggagaggcca gtatcgaaga cgtaggctgg gaaatcttca 275461 ggacgatttt ggatgtggca agcggccgca aacaaacgtg ggcagaccgt tggggtcttc 275521 ataatgattt gtgcttgttt aatcctgctc cagtgacttg attcatgttt ttatagcgga 275581 aagatggaat atgctgtaaa atgaaaatca gcgtatagga aacggagggg ttacagcatg 275641 gcattcatta gattccgagt gacacgaatt caatagtgaa caactctcgc ctgaatgcga 275701 gagaatcggg atgaatccgc ctatgtatga gcccttatat ggttatcaaa aaagagggtg 275761 gcgtgcctgc ccttttttgt gccttcaagc atcccttctc tctactgcag gccggagcat 275821 gagaaagggg aaatgggatg acaaacctta acgaaaaaca gcttatcact gagattgtcg 275881 ggcttgcacg cagccaaggt ttgacggttc attctgagaa cgcgcaattg aatgaaaccg 275941 gaatggactt tcaagttgta tttgccaagg acgacacagg tatgccatgg gtgctgcgaa 276001 aaccgcggcg aagtgatgtt gtggaaagag catctgcaga aggcataacg cttgcctttc 276061 tccgcgcgaa tctgactgct gatgtgccgg attggagaat tcatacaccg gaattgatcg 276121 cttaccccat gttaaaagga acgccggctg ctggaattga cttggaacaa aagcaatatg 276181 tatggaatat ggatcatcag ccgccgtcag acgactttgt ccgcacactt gccgacatac 276241 tggctgaatt acatggcacg gatcaaatat ctgctgggca atccggaata gaagtgataa 276301 ggccagaaga tttcaggcaa atgacagcag actctatggt tgatgtgaag aataagcttg 276361 gcgtatctac gacgctttgg gaaagatggc aaaagtgggt agatgatgat gcatactggc 276421 cgggtttctc ttctttgata cacggcgatc tccacccgcc gcatatcctt atcgatcaaa 276481 atggacgtgt cacaggactt ctggattgga cagaagcgaa ggttgctgac ccagccaagg 276541 attttgttct ttatcaaacc attttcggag aaaaagaaac tgcccgtttg cttgaatact 276601 atgatcaagc aggcggccga atatgggcaa aaatgcagga acacatctca gagatgcagg 276661 cggcgtatcc ggtggaaatc gccaagctag ctctgcaaac acagcaggag gaacacatca 276721 atatggcgct ggaagcactt ggtgtaacat cggattaaga attgacttcg tttcatgaac 276781 cgagtattat aaactctaca aataatagaa cggattaaca atcgtgagga agagcaagta 276841 cgcatcagaa tggaggttca gagagtcggt ggcaggtgtg aaccgatcct cccctgatgc 276901 cgaatgggct tctgaattgc tttgctgaac ggatagtagg cgatgccggg tttctctccc 276961 cgttaccaag agaggagtat cgaaacatag gttttctgta cttagagtga acggctgtat 277021 agctgttaat aaaggtggta ccgcgagacc ctcgtccttt gcataggacg ggggtttttt 277081 gtgtttctta aaggaggtga cggccaatgt acgatggctg gtggtggcat agcagatgag 277141 ttagaaagga ggatatcaaa tggtcattgc aactgatgat cttgaggtcg catgtcctaa 277201 atgtgaaaga gcgggagaaa tcgaaggaac accttgcccg gcctgcagcg gaaaaggtgt 277261 tattctgact gctcaaggat atacgcttct cgattttatc caaaagcatt tgaataagta 277321 aaggagaaaa gctgagctga gatgagagca gaagagcaga gtaagattcg tgaggccgca 277381 gcaggtacga tttttttgct gatcggaaca gtttgttttg cgtctaaatc gatttggata 277441 aaatgggcat accaaatggg tgctgagcca gatgccgtgc tgctatacag gcagctgctg 277501 gctgttccgc tgttttggct gattttttta atataccgtc ctccaatgcc agacggtaag 277561 aaaaaaggag acctatggaa ggcttgtggc gcgggagtgt tttgtttttt tctgtctccc 277621 ttgcttgatt ttatcgggct gaaccatgta tccgcaatgg ttgaacgtat attgctgatg 277681 agctatccgt tgtttgtgtt tggattcacc gcgtgtcgtg accggaaaat gtcctcaatt 277741 caggaccttt tcgcagttct ggcggtcatg tttgggcttt tcttggcgct gggcggctgg 277801 aatgctgagc ttttccaggc gaatatgatt ggagctgtat tcattttgtt atcttcggcc 277861 gtctatgctg gttatcttgt cctttccggg catctcgtcc atcaaatcgg agggatccgt 277921 ctcaatgcat acgggatgac agctgctgga gctgccatga tgctttacac agggataaaa 277981 tcggcggctg gcatgaatac gccaatggca gcatatccgc tttctatgta tggtttgttc 278041 gcagtaattg cagtcgttac cacagtgatt ccatttgtgc taatgcttga gggcataaaa 278101 cgaatcgggg cacagcgagc cgccgccatt tcaatggcag ggcctatcct gacgattttc 278161 tatggagctt tatttctcgg tgaacggctc gggctcattc aagtcattgg atgcggtggc 278221 gtattttttg tcattacggg catggaatac aggaagctga aaacaggaaa aaaagaataa 278281 tttttataaa acacacacgt ttttcaatta caataagtgt aattacgtgt gtgttttttg 278341 attttgtaaa ggttaggtga ggagatgcag cgcatattgc ttgtagaaga cgaccactca 278401 atcagtgaaa tggtggatca ttatttaaca aaagaaggct ttggaattgt gcatgctttc 278461 gacggagaag agggcatccg gctgtttcag cagggttcat acgatttggt cctccttgat 278521 atcatgctcc cgaagctgaa cggcatggat tttctgaaaa tcatccggga aaaaagcaat 278581 ataccggtct taatgatttc ggcaaaagat ggagatgtgg acaaggcatt gggactgggc 278641 tttggggcgg atgattatat cgccaaaccg ttttcgatga ttgagctgac agcccgagta 278701 aaagccgcga tacggcgggc gacgcaatat tcggcagagg agccggctgt gaataaggtg 278761 atccggattc accagcttgc gatagatata gacaatgttt ccgttttgaa aaacggagag 278821 ccgctccagc tgacgtcaac agaatggcag ctgctgtgct tatttgcatc aaatcctaaa 278881 aaagtgttta cgaaagaaca aatctaccgt tccgtttgga atgaagagta ctttgatgat 278941 cagaacatca ttaacgtaca tatgcggcgg ctcagagaaa agattgagga tgacccctcc 279001 tcccctcaat atattaaaac gttatggggc atcggttata aattaggaga gttttagaat 279061 gacagtgcta tgggtggccg ctgtcatcgc tctggcgtgt ctgaatgtga ttcaattcat 279121 aatgaaaaag aagcgggacg ggaatctggc ttacacggct gaccagctta gctacatgct 279181 cagccgggat tcggcaggac aaattttgct tcctacagac gatcatgcgc tcaaagactt 279241 gcttgttaac atcaatctta tcgttgagaa tcgtcagcag atcagcgccc aatttgccaa 279301 aacagagcaa tccatgaagc ggatgctgac caatatgtcg cacgacctga aaacgccgtt 279361 aacggtcatt ctcggttata ttgaagccat tcaaagtgac ccgaacatgc cggacgaaga 279421 gcgggaaaga ttgctgggga agctccgcca gaaaacaaat gaacttattc agatgatcaa 279481 ttcctttttt gatttagcga aattagaatc tgaagataaa gagatcccga tcaccaaagt 279541 acatatgaac gacatatgca aacgaaatat cctgcactat tatgacgctg ttcagtcaaa 279601 aggctttcaa gcagccatcg atatccccga tacgccggtg tatgcgcagg cgaatgaaga 279661 ggctctggac agaatcctgc aaaacctatt gtccaatgcg attcaatatg gcgcggccgg 279721 caagttaatc gggctgacgc tgtcttatga tgagaggaac atcgccatca ccgtatggga 279781 tcgcggaaaa gggattagtg aaaccgatca gcagcgggtg tttgagaggc tgtacacact 279841 ggaagaatcc agaaataaag catttcaagg aagcggcttg ggtttaacca tcacaaaacg 279901 gcttacagaa aaaatgggag gcatcatatc cgtccaaagc aagccgtacg aacggactgc 279961 atttacgatc acattgaaac gcatgacata ttaatcgtaa gaatttctta aggtttgaga 280021 aataaaaatg acagggctcg ccgctacaat agaaaacagg aaaagagagg gaaggagaaa 280081 caaagttgac ttatatcgta caaacaaacg ggctgaccaa aacatatcag ggcaaagagg 280141 tcgtatccaa tgtcagcatg catattaaaa aaggtgaaat ctatggcttt ctcggcccga 280201 acggcgcggg gaaaacaacc attatgaaaa tgctgacgag ccttgtcaaa ccgacaagcg 280261 gtgaaatcat catccttggg aacaagttca cccacacgtc atatgaggtg ctggggaaca 280321 tcggcagcat gattgaatat ccgatttttt atgaaaacct gacagctgaa gaaaatttag 280381 atctgcattg tgaatatatg ggataccaca ataaaaaagc catacaagaa gtgctggata 280441 tggtgaattt aaaacaaatc gacaaaaaac ccgtcaaaac cttttccctc gggatgaagc 280501 agcgccttgg aattgcgcgt gccatcctca cgaagccgga cctgcttatt ctggatgagc 280561 cggtgaatgg tcttgaccct ctcggcatta aaaagatcag gcaattgttt caagtgctga 280621 gcaaagagta cgggatgacg ctgctgatct caagccacct gctgggtgaa atcgaacaaa 280681 tcgcggacac aatcggcgtc attcgggacg gcaggctgct tgaagaggta tcaatggagg 280741 atgtcagggg ccagaacact gaatacatcg agcttgtcac gccgaatcag acaagggcct 280801 gctttgtgct ggagaaagag ctgcaattaa ccaactttaa aatattaaat gagaaaacga 280861 ttcgaattta cgaggctgaa gcctctcagg ctgccatatc caaagcattg attttaaatg 280921 atgtagacat tgaatcaatg aacaaaaagt atacgtcgct ggaggattat tttatcaaat 280981 tgatcaacgg caatagcatc agtgcgtaaa ggaggagaga cacgttgatg aatttgatca 281041 gaatcgaatt aagaaaaatg aaaatgggct ggtatatcag aggtgccctc attgccaacg 281101 tgatcattat gggttttatg tggctgatca gttattccga aaaagccgat ggcggggttt 281161 cgttccaaag tacggatgaa gcattcctca tcatcggcac cttcgtcaga gcggtattta 281221 tcgtatttgg cgctgtgctg atcgtaaaat tggtgatttc ggaatataaa aacaaaacca 281281 ttcttgtgat gttcacgtac ccgatcagcc gtaaaaagct gctcaccgct aagctcatga 281341 tcgcgggcgg actgacgttt atcacgattt tactttcaaa tatactcata gccgccggtt 281401 tcttttggct gaactcgatc tgccatttca taccgggaga gcttacttcc gagatcattt 281461 ctcaacaggc ggtcaaaatg gcggttttcg cttttggcgc cgctggaacc agtttagttc 281521 ccatcttttt tgggatgcgt agacactcgg ttccggcgac catcatttca tctgtagtaa 281581 ttgtgatgct catcagctca acaagtccgg gcttctcgat ttcatctgtt gtgtatatcc 281641 cgttatcgtt agcggcattc ggtttgttct tttcctacat ggcgatcagg aatgcggaca 281701 agcaggatgc gtaaacaaag gcgcccaata tgtataaaag gccgatgctg tcagcaccgg 281761 cctttccatt atgagtctgt tcttgtttca agataatgct tcttgccaat ctctttgctc 281821 atcatataga aatggaagca atattcaccg attgccatga cgatcgcgcc gaataaagcc 281881 gccaatgcaa cttcaccgcc agtcatcccc atagaaagcg gcatgcccat cagccagatc 281941 acgagaaagg ccaaaccaaa atcagccaaa gttgcaatca tattattcca tttcggcaat 282001 acataaagat cgcccagcaa ataagaaata acccctaaca caatcgtcat tagcagcgta 282061 tcaccaaacg tgaaaccaaa gcccagacca agcaccagat acaacacaat aatcgtcata 282121 atacctttaa tagcgagcgc tttcacatgt gtcattacaa ttcctccttt tgtcatttga 282181 tttgttatgt ataattcctc aaatgtaaaa agttaaacct tatttctttt cggaggcggg 282241 tgcaaatctg ctggggagag gtcaatgatg tgaatccagg aattgaggct gcggcgcttc 282301 gacagcggaa acgtgaagct tgtactgcac cggacgctgc tttgatgccc aacagcccat 282361 tatgtttgct gtttttagat gaataaattt aaaaacttct cctgtccctc cgtcatcact 282421 tctgaagtaa tgaaatatga tgaaaagaga tcaaggggag gtgacgtgat ggcggtcgtg 282481 agagcaacga gtgcggatgt cgatttgatg gcaaggctgc tcagagcgga agcggaaggc 282541 gaaggcaagc aggggatgct gcttgtcggc aacgttggaa ttaatcggct gcgggcgaat 282601 tgctcagatt ttaaaggcct ccgcaccatc aggcagatga tttatcagcc acacgcgttt 282661 gaggctgtga ctcatggata tttttatcaa agggcgcgag atagcgagcg tgcccttgca 282721 cgccggtcga ttaatggtga aaggcgctgg cctgcaaaat ttagtttatg gtacttcagg 282781 ccgcaggggg actgtccagc ccagtggtat aaccagccgt ttgtggccag atttaagtca 282841 cactgctttt atcagccgac ggcggagacg tgtgaaaatg tatataacac attttagaga 282901 caggacaccg ttcaaattga acggtgtttt tctttgaaaa gatgcaatgc aaaatattcc 282961 tgtgagataa tcaaagaaaa aagagctgac ggagatgaca gaatggcaac aattgacctg 283021 caaaagaaaa gtgtaaagat cgtactggag aaaaagcagt taacgaaggt gacggctcgt 283081 gttggactgg ttcttgatat tacgggatcg atgagaccgc tctacaaaaa cgggacggtt 283141 caaaatgtgg tggagcggat tttggcagtg gctgatcagt ttgatgataa cggtttgctg 283201 gatgtatggg tgtatgataa tgaattttcc cgattaaagc cagtttcaga aaaggatttt 283261 tcgggctatg tcgatcgtga aattttaaat aatgaccgct tgcataaatt cggcagaaat 283321 gatgagccgc cagtcatgaa ggacgtgctg cgcaaatatg ttacggagga accgagctcg 283381 tatcctgctt tcattgtttt tatcaatgac gggggctgta aaaagtcaat caaaccgata 283441 attgaagctt cttctgataa accggtgttc tggcagtttg tcggcatcgg aaacggaaac 283501 tttgattttc tcaataaact ggatacgtta gaagggcgtg tcattgataa cacgaacttc 283561 ctgcatatcg aagagattga ccgcatttct gatgatgagc tttatgatgc tctgcttgct 283621 gaatttccat tttggctgaa agaagcgaag gaaaaaggga ttgtaagaga acaagagcct 283681 cctgctgaaa agccgaaaaa gaagggcttt ttcagcagat tgttttcgaa ataactgata 283741 aagagcactg agtcattctg cgaaatggct cggtgttttt gtttttttaa gatcatgtga 283801 agaaaaatag gccgaatggg cggcttgcaa acgacaggat atgcagaaaa cgcgtcattc 283861 agccagcttt cggcatgttt cagcagcagg cttgtgaggg aagacctgtt tttaatgttc 283921 agcgcttaca atcagttcac acttcttcac agtcgtttaa caatgatttc ctataatgga 283981 gacgatcaat gaggagagag gggatcttga atggcatacg acagtcgttt tgatgaatgg 284041 gtacagaaac tgaaagagga aagctttcaa aacaatacgt ttgaccgccg caaatttatt 284101 caaggagcgg ggaagattgc aggactttct cttggattaa cgattgccca gtcggttggg 284161 gcctttgaag taaatgctgc gcctaacttc tcaagctatc cgtttacatt aggggtagcg 284221 tcaggtgatc cgctttctga cagtgtcgtg ctttggacac gtctggcacc agatccgctg 284281 aatggcgggg gaatgccgaa gcaagcagtg cctgtcaaat gggaggtcgc aaaggatgag 284341 catttccgca aaatcgtaag aaaaggcact gaaatggcta aaccaagtct tgcccattcc 284401 gttcatgtgg aagcggacgg gcttgagcca aacaaagtgt actattaccg tttcaaaacc 284461 ggccatgaac taagccctgt cggaaaaaca aaaacactgc ctgcccctgg cgccaatgtg 284521 ccgcaaatga cctttgcatt tgcttcctgc cagcaatatg agcacggata ttatacggcc 284581 tacaagcata tggcaaagga aaagcttgat cttgtcttcc atctcggtga ttacatatat 284641 gaatacggcc caaatgaata tgtatcaaaa acaggcaatg tccgcacgca caacagcgcg 284701 gaaatcatta cgctgcaaga ctatcggaac cgtcacgctc aataccgttc tgacgccaat 284761 cttaaagctg cacatgcggc attcccttgg gttgtaactt gggatgacca tgaagttgaa 284821 aacaactatg ccaataaaat acctgaaaaa ggacagtcgg ttgaagcatt cgtgctccgc 284881 cgcgcggcag cataccaggc atactatgaa catatgccgc tccgcatttc ctctttgccg 284941 aatggcccag atatgcagct gtaccggcac tttacgtacg gaaacctggc gtccttcaat 285001 gtgcttgata cccgccagta cagggacgac caagccaata acgacggcaa taagccgcct 285061 tctgatgaat cgcgcaatcc gaatcggact ctgcttggaa aagaacagga gcagtggctc 285121 ttcaacaatt tgggcagctc gacagcccac tggaatgtgc tggcgcagca gattttcttt 285181 gccaagtgga atttcgggac aagcgcaagc ccgatctaca gcatggattc gtgggacggc 285241 tacccggctc agcgcgaacg ggttatcaat ttcattaaaa gcaaaaatct gaataatgtt 285301 gtcgtactga caggtgatgt acacgcaagc tgggcatcga atttgcatgt cgatttcgag 285361 aagacaagtt caaaaatatt cggagccgaa tttgttggaa cctcgatcac ttccggaggg 285421 aacggagcgg ataagcgagc ggatacggac caaattttaa aagaaaatcc gcacatccag 285481 ttctttaacg actatcgcgg atatgtccgc tgtacagtga cgcctcacca gtggaaagcc 285541 gattatcggg tgatgccatt tgtgaccgag ccgggcgcag ccatttccac gcgggcttca 285601 ttcgtttacc agaaagacca aaccgggttg agaaaggtat catccacaac aatccaaggc 285661 ggggtgaagc aatccgatga ggtcgaagag gatcgtttct tttcgcacaa caaagcccac 285721 gaaaaacaaa tgattaagaa gcgtgcaaaa atcacgaatt aaggagtgga aattatgttt 285781 tcaaacattg gaataccggg cttgattctc atcttcgtca tcgccctcat tatttttggc 285841 ccttccaagc tgccggaaat cgggcgtgcc gccggacgga cactgctgga atttaaaagc 285901 gccacaaaat cacttgtgtc tggtgatgaa aaagaagaga aatcagctga gctgacagcg 285961 gtaaagcagg acaaaaacgc gggctgaatg ctgatgaggc agacaccggg tctgcctctt 286021 tttttatgaa agggagggct tttttgaatg gataaaaaag aaacccatct gatcgggcat 286081 ttagaagagc ttcgccgccg gattatcgtc acccttgcgg cattttttct atttctcatc 286141 acggcttttt tgttcgtaca ggacatttat gactggctga tcagggattt ggatggaaag 286201 ctggctgtgc taggaccgag tgaaatcctc tgggtgtata tgatgctttc cggcatttgt 286261 gccattgcgg cttctatccc tgttgccgcg taccagctgt ggcgtttcgt tgcaccggcg 286321 ctgactaaaa cggagcgcaa ggtgacgctc atgtacatac caggtttatt tgcgttgttt 286381 ttggcgggca tctccttcgg atactttgtc ttgtttccga tcgtgctcag ctttttgact 286441 catttatcct ccggccactt tgaaacgatg tttacggctg accgctactt taggtttatg 286501 gtgaatttga gcctgccgtt cggcttcttg tttgagatgc ccttggtggt gatgttttta 286561 acaaggctgg gcatcttaaa tccttacaga ctggccaaag cgagaaagct ttcctatttt 286621 ctgctgattg tcgtgtccat attgattaca ccgcctgatt ttatttctga ttttctcgtg 286681 atgatcccgc ttcttgtcct gtttgaagtg agtgtcaccc tatcggcgtt tgtctacaaa 286741 aagaggatga gggaagaaac agcggcggcc gcttagtgca gcgtaccacc cggtgacttc 286801 acatcctcat catattgtgc ggccgtaaca gcggcgattc tcaatgcccg gacaatcgtg 286861 tccaggctga ggctcggcgc tgttttgtcg attgtttgct gcggaatgta aggaatatga 286921 ataaaaccgc cgcgaatgtg tggggatgtc cggctaatgt gatccattaa cccgtagaac 286981 aaatagttgc atacaaaggt ccccgctgtg taggaaaccg cagctggaat gccgtgttcc 287041 ttcatcttag cagtcattcg tttcacggga agccttgtcc agtaagcggc gggcccatct 287101 ggagaaatct cttcatcaat cggctgatgt ccttcgttat cggggattcg cgcatctgca 287161 aggttgattg ccactcgttc cggtgtaatc tgcatccgtc ctcctgcttg gccgacacaa 287221 attacgatat ctggctgatg tttttgaatg gcttggcgca gagtgtccag agcggatcta 287281 aagacggttg gaatttgttc cgctgtaata atggcttctt ctgtctcgaa gccattaagc 287341 cgtttcgccg cttcccatga tggattgacg gtttctttgt caaaagggtc aaagcctgtg 287401 atcagcactt tttttctcat tctcccatct cctttttctt ttattctatt gtttatttat 287461 gggtttttca tcaaaataat gtaaaggagt gaatcataat ggagcatttg ccggagcagt 287521 atcgccagtt attcccaacc ttgcagacgc atacgatgct tgccagctgt tctcagagcg 287581 cattggcaga gcctgtatca agggcgatcc aggattatta tgatagcctg ctgtataaag 287641 ggacgaactg gaaagaagcg attgaaaaaa cagagtttgc gagaaacgag tttgcaaagc 287701 tgatcggggc tgaaccggat gaagtggcga ttgtgccgtc agtttctgat gcactggttt 287761 ctgtagcatc gtccttaact gcatttggaa agaagcacgt tgtatataca gatatggatt 287821 ttccggcggt gcctcatgtt tggcaggcac actccgatta taccgtatcc gtcattccat 287881 caatagacgg cgtgctgccg cttgaacaat atgaaacgca tatttcggat gaaacagtac 287941 tgacgtgtgt tcctcacgtt cattatcgtg acggctatgt tcaggatata aaagcgattg 288001 ccgagatttc tcagagaaag ggctctttat tgtttgtaga tgcttatcaa tcagccgggc 288061 atattcccat tgatgtgaag gaatggggcg tagatatgct ggcagcaggc acccggaagt 288121 atttgctcgg cataccgggt gtggcgtttc tttatgtgag aaaggagctg gctgacgcac 288181 tgaagccgaa agcatcagct tggttcggaa gagagagcgg atttgatggg gcttatgcaa 288241 aagtcgcgcg ccgttttcaa acgggcaccc cagcttttat cagcgtatac gcagctgcag 288301 cggctttatc gctgctgaat catattgggg tttctcatat cagggatcat gtgaaaacga 288361 tctgtgccga tgcagttcaa tatgccgctg aaaaaggcct gcagctggcg gcggcacaag 288421 gtgggattca gccgggcatg gttgcgatcc gggatgagcg ggcatcggaa acggcggggt 288481 tgctgaagaa gaaaaaagtg atttgcgcgc cgcgggaaaa tgttatccgt ctcgctcccc 288541 atttttataa tacgaaggag gaaatgcggc acgcgattga tgaaatcgcg gcgaaaacga 288601 tccacaagta aacatgaaaa agcccctgaa cactagtcag gggcttttca tattaatgat 288661 ctactttaac gcgtttcata aagaaagcgc caattaaacc gataatggca acaatcattg 288721 caaacacaaa tgcgtgctgt acgcctgctg tcaaagcttg cgggatgact gccggatcgg 288781 cagggttttt aactgtactc atataatcat gctggcctgc agccataatg ctgaccgcaa 288841 ccgctgttcc gatagcgccg gccatttgct gcagcgtgtt cataatggcg gtgccgtctg 288901 gataaaattc acgcggcagt tggtttaaac cgtttgtctg tgcaggcatc atgatcatag 288961 aaatcccgat catcaagcag gtgtgcagga tgataatcag cacagctgtt gaagtggtcg 289021 tgacatttga gaagaaccat agtacaacgg tgacaatcac aaatcccgga atgacaagcc 289081 atttcggccc gtatttatcg aacaagcggc ctgtaacagg ggacataaat ccatttaaaa 289141 taccgcccgg caagagaaca agaccagatg caaatgcagt gaggactaag ccgccttgca 289201 gatacatcgg cagaagcagc atagatgaca gaatgaccat catacaaatg aacaccatga 289261 tcacacccaa aataaacatc gggtatttga acgcacggag gttcatcata ggctgcttca 289321 ttgtcagctg gcggattgaa aataagataa ggccgacaac gccgacaatc agcgacacga 289381 taacagtcgg gctggaccat cccccggagc cttcacccgc gttgctgaat ccgaatacaa 289441 tgccgccgaa gccaatcgtc gacaggatga tagacaatac atcgattttc ggctttgtcg 289501 tttcagatac attttgcata tatgcgatac cgaaaacaag cgccagcaca aggaatggaa 289561 gagagatcca gaaaatccag tgccagttga gatgctccag aaccaatcct gagaaagttg 289621 ggccgatggc gggcgcgaac ataatgacaa gcccgatcgt tcccattgcg gcaccccgtt 289681 tatgaggcgg gaaaatcacc aagattgtgt taaacatcag cggcagtaaa agaccggttc 289741 caagtgcctg aacgatcctt gccgctaata aaaacgagaa gctcggcgca agcgccgcaa 289801 tgaatgtacc taaaattgaa aagataagtg acacggtaaa aagctgtctt gttgtgaacc 289861 actgcaacag cagtcctgaa acaggaacaa ggataccgag tacaagcagg tagcccgtcg 289921 ttaaccattg gacggttgcc gctgtaatgt tcaattcctt cataaggtcg gttaacgcaa 289981 tattcagcgc tgtttcactg aacatgccga taaaaccggc caacagcaag gaaatcataa 290041 tcggcatcac tttgtattgc tgagatgctt tagctgttgt ttccaaaatc atttcccctc 290101 tctatcaact gcatgtagta tgtcgttttt tttatctctt cagcaggtca ggaatgcagc 290161 tggagatatg aaggagcggc gtactgtttt ttgccgtcaa agataaaagg atgccgcctt 290221 caatcatcgc gttaaccaca gtgctggctt cttttgcacg gctctcgctg cagccagtct 290281 gccgcagttt ttcctcatac acagaggccc attctttgta ggcttcatga caggcttcgc 290341 gcaacggttc gcttttcaat gacgtctcag ccgctagcaa gcccacaggc aagccttcaa 290401 tgtcttccgt acatgaaaac tggcaggaga gctccttcaa aaaggcttga atgccttccg 290461 ctggatcggt gcaggcttcc atgcagtccg cgattttctg acggatatac tccttcatct 290521 cattcacggc ttcgatcgca agctgttctt tacccccggg aaagtggtag taaagagagc 290581 ctttaggcgc gccgctttcc tttataatct ggttcagccc cgtgccgtaa tacccttgca 290641 gctgaaaaag ccgggtagct gccgaaagga ttttctcacg ggaatctcca taactcataa 290701 cattcccacc ttactgaatt gcaatcaaaa atatagtgac tggtctatta tcttgattca 290761 atcatcaatt gtcaagaaaa attcattgta tgaaaagaca aaaaaagaag gatatgacaa 290821 caaaaaatac tgagagaaaa gctgactgat cttttgactg aatagataaa atgtacaatg 290881 attaatcatc atatggatgt aaggagagaa atagatgaaa aaacaacgaa tgctcgtact 290941 ttttaccgca ctattgtttg tttttaccgg atgttcacat tctcctgaaa caaaagaatc 291001 cccgaaagaa aaagctcaga cacaaaaagt ctcttcggct tctgcctctg aaaaaaagga 291061 tctgccaaac attagaattt tagcgacagg aggcacgata gctggtgccg atcaatcgaa 291121 aacctcaaca actgaatata aagcaggtgt tgtcggcgtt gaatcactga tcgaggcagt 291181 tccagaaatg aaggacattg caaacgtcag cggcgagcag attgttaacg tcggcagcac 291241 aaatattgat aataaaatat tgctgaagct ggcgaaacgc atcaaccact tgctcgcttc 291301 agatgatgta gacggaatcg tcgtgactca tggaacagat acattggagg aaaccgctta 291361 ttttttgaat cttaccgtga aaagtgataa accggttgtt attgtcggtt cgatgagacc 291421 ttccacagcc atcagcgctg atgggccttc taacctgtac aatgcagtga aagtggcagg 291481 tgcccctgag gcaaaaggga aagggacgct tgttgttctt aacgaccgga ttgcctcagc 291541 ccgatatgtc accaaaacaa acacaactac aacagataca tttaaatcag aagaaatggg 291601 cttcgtcgga acaattgcag atgatatcta ttttaataat gagattaccc gtaagcatac 291661 gaaggacacg gatttctcgg tttctaatct tgatgagctg ccgcaggttg acattatcta 291721 tggataccaa aatgacggaa gctacctgtt tgacgctgct gtaaaagccg gagcaaaggg 291781 gattgtattt gccggttctg ggaacgggtc tttatctgat gcagccgaaa aaggggcgga 291841 cagcgcagtc aaaaaaggcg ttacagtggt gcgctctacc cgcacgggaa atggtgtcgt 291901 cacaccaaac caagactatg cggaaaagga cttgctggca tcgaactctt taaaccccca 291961 aaaagcacgg atgttgctga tgcttgcgct taccaaaaca aatgatcctc aaaaaatcca 292021 agcttatttc aatgagtatt gaagaaaaga aggcgaataa gccttctttt ttttggcttt 292081 ttaggaccaa taatgacctc tgaatcttaa aatttcttta aaaataagcc aaaattaccc 292141 tttacttaat taatttggta acgtaatata attggagaat ttgttacaaa aaaaggagga 292201 tattatgaaa tttgtaaaaa gaaggatcat tgcacttgta acaattttga tgctgtctgt 292261 tacatcgctg tttgcgttgc agccgtcagc aaaagccgct gaacacaatc cagtcgttat 292321 ggttcacggt attggagggg catcattcaa ttttgcggga attaagagct atctcgtatc 292381 tcagggctgg tcgcgggaca agctgtatgc agttgatttt tgggacaaga caggcacaaa 292441 ttataacaat ggaccggtat tatcacgatt tgtgcaaaag gttttagatg aaacgggtgc 292501 gaaaaaagtg gatattgtcg ctcacagcat ggggggcgcg aacacacttt actacataaa 292561 aaatctggac ggcggaaata aagttgcaaa cgtcgtgacg cttggcggcg cgaaccgttt 292621 gacgacaggc aaggcgcttc cgggaacaga tccaaatcaa aagattttat acacatccat 292681 ttacagcagt gccgatatga ttgtcatgaa ttacttatca agattagatg gtgctagaaa 292741 cgttcaaatc catggcgttg gacacatcgg ccttctgtac agcagccaag tcaacagcct 292801 gattaaagaa gggctgaacg gcgggggcca gaatacgaat taatgaaaaa caaaaccttg 292861 aagaatgcta ttcttcaagg ttattctgct ttcagcacaa tggttttcgc agccatatca 292921 tgaacggttt gttttttctt cgtaaatgcg gcagtcaaat agatcaggcg ggagaacaca 292981 tgcacccacg ctatcaggta acggacaatg gcttgcggga aggatatttt tttatatgtt 293041 tcgtccctca cgatttgcag cccgatgatt tttttgccca gtgtgccctt ccaatttgtc 293101 agcggcatca gcaaagggta cacaatcagc atcaatatgg cgacaataat gacaccggcg 293161 gacccatcgc caaacgtaaa tccggctgcc aaaatcactg ctgcggcaat gattacatca 293221 agtaaaagag cgcaggcgcg cagcatgaaa ccagctagtt ccaatagaaa cactccttaa 293281 aatgttaaat aaacacctaa tgattgtaaa aaagaagggc ctaaagtggg aataggtgat 293341 aagccttaaa tcacaaaagt tggtgaaaat gtcataggta aattggcata atcagccagc 293401 ttatcacatt accaaattct tttttagccc gaaaccaagc cctcagaagt tatttttgtt 293461 aaaatagaaa agttacaaca gaattcggag ggtttattgt gggaaaagtg aaacgaaatg 293521 ccccttgccc atgcggcagc ggcaagaaat ataaaaaatg ctgcggaagt aaagttgtcg 293581 acttcccggc ggaactagcg gcaaaagaag cgaaacaaat tcaggaagac ttagtggagt 293641 atgccttcac agtacataga gaaagcattt caggctttat caaccagcat gattttcttt 293701 ctgctatgga cagacagacg aaagacatca gcgtatttaa cttaggaatc tggggaatct 293761 tcttccaccc gcttgctggt gagaagacaa tcttcgaaga gtaccttcag aaaaaaggcg 293821 attcgatcac tcgtccgaaa acgcgtgaga tcgtagaatc atggcagagc atgacgcctg 293881 ctttattgct gctgaaggac ctgaaggaag gcatcattca ctttgaagat gtcattacgg 293941 caaaacaatt cgaagtggaa atggacgcca gcaatcaaga ccttcctcca gtgggaagcc 294001 tgattcttgg atacccaatc cacgaagcgg aaaaagcaga attcttcatg cagttcacga 294061 tcttcccggt gaagagaaca gaagcgctga tcagcaaggt gaagaaatat gcggatgccg 294121 ctgtgaagga cggcaaaacg ccggaggact tcatgaagca ggaattcaac aacgttctgt 294181 tcgcgttgtt agctgagaaa gatgaagagc cacaagcaga gaaagcggaa gtaagcactg 294241 ttgagtgggc aaacgacttg gagaaagaaa ccgctgcggc tattgaagaa ggcatgagcg 294301 gggaagagta tccgactgaa ttgatcccag ctgttattga catctggaaa acattctgcg 294361 agaaaaaatc acctgtcatc agaaagccgg aagcttttgc ggcggcagtt gaatattatg 294421 taaacgcaat ttctcttaac ggcgcgtccg tttcccaggc taaactggcg aaaaaatacg 294481 gcgttagcgc atcaacgatt tccagccgtt acaaagaaat tgaaagcacg ctgcaagatg 294541 aagcagatcg ttttgcacaa gcgttatcct cataatggaa aaaaccttga aaagccaggc 294601 ttttcaaggt ttttttattt ctgaaacgga attttgattt ctaaccggaa gatggggtgg 294661 cggtaggtaa aatccagcct gccaaaagcg cccttcacca gtttttgaat gatatatgtg 294721 cccatgcctt catgagcgcc gtttttcgtt gagcggccaa acgattgata aattgtatcg 294781 agcacttttg ggtccatccc gggagtgctg ttttcacaag tcagtacata aagcccgctg 294841 cgcagtgaag tctccagttt aatctctgct ttttctcggg cctccgccgc gctgtcgagc 294901 gcattttcta atatgttgcc gaccaagctg acctgatcag caggcgaaaa cggaagggaa 294961 gaaagcggtg tatgcatatg cagcgaaaca ctcacattcg aggcgcgggc tttttctaaa 295021 aaatcataaa gcacccctgc aacgtacgcg ttctctcctt tcaaaaaacg gtcatattgg 295081 ctgtattgat ccgcccagtt ttgaatatat gcttgtgtat ctgccttggg ctgagctgat 295141 ttgattgcag tgatatgttt cattgtgtca tgattccggc ttctgacatc aatcagcatt 295201 tgattggcgt gctgttcagc ttgagtcagc ttatcaattt gatcagaaag ccttgcctgc 295261 aaagcagact gtccgatacg gagcccttca caccctgcaa atatcgcgat tacacataat 295321 accggcatga tgtctgtgcc aatcaacacc actcccaccg acatcacttg aatcaccgca 295381 atccacgcac aaagccctga ggaacagtgt ttccacaccc gcttcgtatt ccaaatgtac 295441 aatcctgcag cagctgcgcc taaagcagcg gcgagccaag aggcggctgt gctgtgtgaa 295501 aaagcagcag ctccctgata acatatgaaa ctaaataaaa tcagataaag acattgaaaa 295561 agggtaatca cgtactaaac tcctcaaaaa tagtagtttt gaaaataatc aagctgctgc 295621 ttagtgatca tcgctttttt agacgttccc tcaaaggaaa ctgtgaatga atgcttggta 295681 taagcggaaa aatgctttat gtaatgaatg ttgataataa aggaacgatg cgaacgaaga 295741 aaatcttttt cgggcaggtc gcctttaata tcatttaatg tttgatacgt ttgcacctct 295801 tcggcggttg tcacaatcgt cgtcgaacgt cccgtccgtt ctgcgaaaat aatatccttc 295861 ttttgcagga cgtgcatttc agacttttgc tttatcaata tacgcccatt caaactcgtt 295921 tccgttttct ttttcaagta ccggtcgaag gaagcggcca gacggtcggc atagtacggc 295981 ttcataatat aatcatggac gttcaggtca aaggcgtgaa ccgcataacc gccgtggccg 296041 gtaacaaaaa tcacatccac atcaagtgaa tgggatttga tcaaatcagc aagctcgtag 296101 ccagacatat ggggcatctc gatatcggca agcagcagat caatgtctcc gttctttacc 296161 cgcctgtagg cttccttcgc tgaatcggtg gaaaagacaa tttcgacgtc ctgcattctg 296221 gacacgatcg cttctaactt ctctaaatct actcgataat catctacaag tccgactttt 296281 accattatca ttcccctagt tacatagaat catctttatt ctatcccatt tcacgacata 296341 aaaagaactc ttcgcgacaa ctttatccaa ctaatccagc ttttcgtata tagtcattac 296401 tagaaataaa gataagggag attgtgacat gattacactg accgattgca gccgcaggtt 296461 tcaggataag aaaaaagtag tcaaagcggt gcgagatgta agcttaacaa ttgaaaaagg 296521 agaagtcgtc ggcattctcg gagaaaacgg tgccggcaaa acgacgatgc tgagaatgat 296581 tgcttccttg cttgaaccat cacagggtgt aatcacagta gacggctttg acacggtcaa 296641 gcagccggct gaggtcaaac aaagaatcgg tgtcttattc ggaggagaaa ccgggcttta 296701 cgacaggatg accgctaaag aaaatctcca atacttcggc aggctgtatg ggctgaaccg 296761 ccacgagatc aaagcaagaa tagaagattt atcgaaacgg ttcggcatgc gcgattatat 296821 gaaccggaga gtgggcgggt tttcgaaagg catgaggcag aaagtcgcca ttgccagagc 296881 gctgattcac gatccggaca tcattttatt tgatgagccg acaactgggc ttgatattac 296941 gtcaagcaac atcttccgcg aatttataca gcagctgaaa agagaacaaa aaacgattct 297001 tttctccagc cacattatgg aggaagtgca ggcgctctgt gacagtgtca tcatgattca 297061 cagcggagag gtgatttacc gaggggcgct tgaatcacta tacgagagcg agcgcagtga 297121 ggatttgaat tacatcttta tgtctaagct tgtcaggggg atttcttaaa tgctgagcca 297181 tatttataaa aaagaaatga tcgacgcttt acgcgacaga aaaacgatat tactcacaat 297241 cttagtgccg atgattatga tgcttggact tgtctttttt tatgaaagca tgctgtccga 297301 caaaggggag cagtacacgc tggctgtcgg ccattcgctt ccgcccgcac tggaaagcaa 297361 gcttaatgag attgacgaaa tcagcgtaaa aacatttgca aagcctgaag aggcagttga 297421 tgaaggaaaa gcagatgcct atctgaacgt cccgaaagag ttcgactcat atgtcaacag 297481 catgacacct tttaaggttg atgtttacgg caattcaatc gatcaagggt cgtcaaatgc 297541 catgcagctt gtgcagtctg ccttagatca gtacaaaaat gaaattgtgc agcaacgttt 297601 aacaaataag catattgatc aatcggtgat ccagccgttt acaattcagc aaaaggaagc 297661 ggatgaggag aaagggactt ccgctattat gctttccgcc attctgccca tgctgattct 297721 gacttccatt gtttccggcg caatgccgat cgctcttgat atcatggccg gtgaaaagga 297781 ccgaaagtca atcgaggcgc tgctattaac gccagtcagc agaaacaaag tgctggtcgg 297841 caagtggctt gcggtttcca cttttggcgt ggcttcaggt gtatttgctt tggtgttttt 297901 gattttgtcc accgtgttat ttaccgaaaa tttaaaaacg gccttccagc tgggagatca 297961 tatgtggagt gtaatcggcg cttcagcctt aatcattgtg ctctctgcat tgctgatatc 298021 tgcgatggag cttttcatca gcatcatgtc cagctcggta aaagaagcgc aaagttatat 298081 gtctctcgtc gtctttctgc ctgtgttccc gatgtttttc atcttcagca aggcaccgaa 298141 ccaatttgac ttatcatact ttctcatccc gtttctgaac ctgcatgcgt tatttaaaca 298201 gcttttattc gggatggttg acccggctac cattttgtct acgtcaggaa ccatcgccgt 298261 gctcatcgcc atcttctttt tactagccag agcctgcttc ctgaaagaca aatgggttct 298321 tccaaaataa acttgcgaaa ggagaaatac actttctcct ttttgtatat cctgaaaaaa 298381 gaaggaaaat agaaaaagga tatctaatac aaaaagtgac cctgcactat ttttcatcaa 298441 aattggtttc aaaggagaag gaacaatgga tcaaacacgt acactcggca aaacgaagct 298501 gaaggtgaag cggatcggat tcggcgcgaa tgcggtcggc gggcataatc tatttccaaa 298561 tctaaatgat gaaacaggga aggatttagt gcgcacggca ttggatggcg gcgtcaattt 298621 tatcgatacc gcctttatat atggattggg gcgatctgaa gaattaatcg gcgaagtcgt 298681 acaggaacgc ggcgtgcgga atgagctcat catcgccacc aaaggagctc ataaagaagt 298741 ggacggcagc attgaattag acaatagccg ggagtttctt cgcagcgagg tggagaagag 298801 cctgaagcgg ctgaaaacag attacattga tttgtattat gttcactttc cggatggaaa 298861 aacacctctc gctgaagtgg cgggcacttt gaaagagctg aaggatgagg ggaaaatcaa 298921 agcgatcggc gcttcgaacc tcgattatca gcaattgcag gattttaatg ctgacggcta 298981 tttggaggtc ttccaggccg aatattctct catacagcgt gatgccgaga aagagcttct 299041 tccatactgt gaaaaacaag gcatctcctt tattccttac tttccgcttg cgtccggact 299101 gctgacagga aaattcacgc aagacacagt ctttgatgat ttcagaaagg ataaacctca 299161 atttcagggt gaaacgttta tccacaatct caaaaaagta gataagctga aagcagtagc 299221 ggaggaaaaa caagcggata cggcacatgt cgccttggcg tggctgttaa cgagaccggc 299281 gattgatgcc attattccag gagctaaacg accggagcaa ttacaggata acctgaaaac 299341 cttgaacatt gaactgaccg aagatgaagt gaatttcatc agcgacattt tcaaataaaa 299401 aaggaaatag ccgtcatggc tatttccttt tggtgtttta ttctttgatg aatgcttcga 299461 ctaattctgc tgctctgtaa tcatccatat caagctgcca ttggtcgatg tcatttttct 299521 tcattttcac ttcaactgtt ttttcagatg aagcaggtcc aagctttttg aattcctcag 299581 gatagacttg aagcgcgtat ttcactgcct cttcatagct ggcactagag tttttactgt 299641 agtagtcttt cactttgtct tcgatgcggt ctgaaagaga agatgcatct acaggtttaa 299701 ctgtggcttc aacaattgct tcgtctttag agattgaagt cgtttttgct tgaatggaag 299761 agtttttgct taatccctct ttaatgccgt tcacgatatt atcaagcgct ttgctgtccg 299821 catatgtgct ggaaaggccg gaagctgaga gataaccgtc tttggctgat tcattaaaat 299881 catttacaat ttcatttttg ttagcgccgg tgattttttc gaaatcggcg ttatctttgc 299941 cgaaaagaag gacatcaaca taagctgata acgcttttgc agaatcttgg agcttatctg 300001 ccgtcgccag gatttttttg tcttttccgt caattttaaa agtaactgat tttggctttt 300061 tatcaccgta agattccggc gtatagttaa gctcgtattg cttgccttta tctacaacga 300121 agaaaagatt tccttcaacg gatttgtcag cgttaatcgt gctgccctga agcttttcgc 300181 tatagtcttc agggtctgtg tcagacattt tggtatcacc ttgatacaat gtgaaatcca 300241 tactgtctac attcagcggg tcttttcctg tgtttttcac cgcgacattg acttttaaca 300301 caagctggtc atctgaagtg gacttatcat atttagacgg aagtgtgtaa gagacatcct 300361 tgattttgac ttgagctata tctgagcttt tttctgtttc tgattctttc ttctccgcgc 300421 ttgttttgct gccggaacaa gcagctgtaa acatcatcag cagaagaatt aggaaaacag 300481 cgtacgtttt tttctgaaac attcattttt cctcctcaaa tggtttagga aaggggagtc 300541 ttttgtcttt gagaaatgga tctttttgaa tggattagca tcatataacc aaaaaaatca 300601 gttcttttct cacggttttc accggatttt ctggaaactc cgccctcctt tgtcatgaat 300661 ggacctataa aaagttacaa cggaattaat tttaagatta ttagctttta tattgaatag 300721 gttcatcatc ctatttttgg tgaaaaatgt tctggtaaaa ctggtaaact cagaaaactg 300781 tgtattttag actattactt tttgattagt tggagggaac ttaagaagga tgaaaggggc 300841 cgcctttgtg aagaaagagg gactgaaaca aaaagcactg gaaatcggcc gggtgccgac 300901 acacttaaaa ctggaaattg aagattatgg cggtgatgat aaaagagctc atttttgttg 300961 ggcagatcct caggatgaga ataccggcat tatcgtggag cttggaccgg acggagagct 301021 ggaatccctt tcccgtgata ttgagcctga aagcggagaa aggctgtctg aggagaaact 301081 agaggatatc atgcgccaat ttgtcgagac tcatcatccg ggggcactct ctgcctttgt 301141 tcgtgaagaa aatgaccgtg catacggcga taaagtgaga ttttcatatg ttcaaatgga 301201 ggctgggctt cctctcccca tgagcggatt tatggctgat gtttccttat caggtgagat 301261 tgtttacttc cgttattacg gcgaagcggg cagcatcatc aagccaaagc gggtcgcgga 301321 tgttgaagag gcacttgcct ttatcaagaa ggacgtggag ttcgaccttt tgtttgaggt 301381 tctccatcgt tctgtttaca aaaacggaga tgatcagccg catttggtgt acgagcctga 301441 aggtagggcg attaccgtac ctgcggattt ggttcaagaa gaacaagcag ttgatgatga 301501 cgatgattac agggagccgg agagctttcc tctcccttta ttcgagggca tccgcgaaaa 301561 ggccgatcct gacagcatga ttggtattga aaatgggttt gtcaaagagc gggaagcgga 301621 tttgggagat gggagaattg gaatcgtttg gcggaatccg gatgaccctg tgtatcagcc 301681 ggcggataaa agcatggaca gctggtttaa gggacggact catcaagtgc tgaaaaccat 301741 ctataacaaa gaaaccggaa aactcgaagg cgtcatgtca tttatggaga aaaaagggcc 301801 gctgacagta accttggcag agtgtgaaaa aatcgcgctt cgctttctat ttgctttatt 301861 tccgaatgcc gatcaatatt ttaggatcag atacgacgaa aaagatgaag aagaaaacgc 301921 agtcgctggt tttacgtttg aagcgcattg tcacggagtt ccgctccgat ttgggcagat 301981 cagaatttgt gtcagccgcc agacagggta tatcaccgtt tatatgggac cggatattga 302041 cccaaataag ctggcaacca ttgatcctgt gccggctatt tcagttgaac aagccaagtc 302101 tatcttttgg cagcatttta aagttgagct tggctgggaa agagagtacg gggatgatga 302161 agaacacagc taccggctcg tctataagcc ggtgtatccg cattttatcg atgcacatac 302221 aggggagcct gtcttcagca tatggtgaaa cagccaaaag tcacgcaatt gcctcagata 302281 tagaagagag tatgtgatga aagtaacaga aagaatctca aaaaacaatg acaataatag 302341 aaaaggacct ttcttcactt taaatgaaga aaggtctttt tatataataa acaggattct 302401 ctttgtcgta gactctttga aagggatgac ttcattggtt aataaacagc tgaaaaagaa 302461 ggcgcaggag atcggaaatg taccgacgca ttatgagctt gagatagaag attacgacca 302521 aaagcaaaag aagtacgggc aggcatattt tatctggaag gaccctaaag atccggaaaa 302581 gcacattaca gttgaactta gaaatgacgg cgccttgctc accttttcaa caactgtcca 302641 ctccgagaca gacaaaaaac ttccagatgc cgagctgaag ctgacggctc ttcagtttgc 302701 cgctgccaat catcccggca catttatgaa ttttcatttt caaggcaagg aagaaagggg 302761 gcagcacatc cggtttgtct ataccaaaat ggagctgggg cttccgattc ccaattcagg 302821 ctttttaatt gatatgacac gaagcggtca gattgtccac tttctatatt acggggaagg 302881 gcataaagcc gaagttccga cggaatttgt agcaaaagag aaggttgtat cccattactt 302941 aaacacaatg tcttttgagc tgatgtacga tgtcattgat ggcgaacagg aaccaaggct 303001 tgtatatgaa ccgattctac cgggatacag ctatcccgca gatgtagacg aaattgtgcc 303061 cgaccagcat atcgcagatg aaagaataga aaacacggcg ccactgccgc cgcttcagaa 303121 caaggaagaa gttgatatat ttgccttgct gggttttacc tctgatatgc agaaagtcag 303181 tgaaagagac tttggagaac aaattggaag cacgtggcgc aggggcgctg cgccggagcg 303241 taaggattta agcataggaa gctattttga aacgagaaat aaaaatacaa tcaaaatgaa 303301 gacggataaa agaaccggaa aattaaaagc agcgctttct tttatggact ggcggaacaa 303361 cctccaatgc tccacggaag aatgccaaga gatagcgctt caatttttgt atgccctcta 303421 tccgagagcg gctgagtttt tcagggtgaa tcccgtccga attgatgaaa gagggagagt 303481 ccgcaaccat ttttctgtct ggtataaagg agtgccgctg cggttcggcg ctgcccgcat 303541 cattgtcaat ccggaaactg ggttgattga cgcttttatg gcgcctgata ttgaacctga 303601 acaattggaa gcgataaatc acaggccgga tgtttccgct gaagaagcga aagaagcatt 303661 tttagccgct tttgatgtga aactggaatg gcagcctgat tttacagcag gcagtgacca 303721 gcactgcaaa cttgtctata agccggttta cccttcctat attgatgcgc acataaggaa 303781 aaagaaaagg ctgtgagggg tgtctagtta ggaatcatct ccaagtgggg gtagtccttg 303841 aatcgtttcc aatccccgcc ccattcgaaa ccgagtgtct tagcgatctc gacaacctcc 303901 agccaatctg attttccgtt ttgattgccg tcatattcca tatcccatat gatgctgcca 303961 tccttttttt gaagggcgaa atcaatcgct aaaccatagt tatgatacga ttcccctcct 304021 cttgcatagg tgacaatatt cccttttttt gtacgtccct gtttatataa ttcatcttgt 304081 tccttaaagg acctgaatcc ttcagtaatg acgacgtcaa tgcctttatt cgctgcagcg 304141 gctttgagtg catcggcatt ctgcttcaca atcggatgaa gatccgaggg gacaggcatg 304201 tcctgcaagg cgttttgaga atgccattca tgccgaatat aactaaaaca aagatctaga 304261 agaaatagaa tacataagat aacaaatgtt tttgcgggta agttcatatc ggtctcactt 304321 tctcaagatg tgctgaatgt taacgctttt aagtgattga ctctctctaa aagcgaacag 304381 ctatgataaa atataacata aatagtagca ggaggaagga ggcagaccga tgagagcaaa 304441 gattccatca gaagaagtag cagtaaagct gaatgaatgg tacaagctca ttcgcgcatt 304501 tgaagcagat caagcagaag cgttaaagca ggagattgaa tatgatttag aagatatgga 304561 agagaatcag gacttgcttt tatatttttc tttgatggaa ttccggcatc gaatcatgct 304621 tgataagctg atgccggtga aagacagcga taccaagcct ccgttctctg atatgctgaa 304681 cgaaattgaa agcaatcagc aaaaactcac gggcttactg gaatactact tttattattt 304741 cagaggaatg tacgaattca agcagaaaaa tttcatatta gcgattgacc attataaaca 304801 tgccgaggaa aagctcgagt atgtcgagga tgagatcgaa aaagctgagt ttctttttaa 304861 agtcgcagaa gtgtattatc acatcaaaca aacgtatttt tccatgaatt atgcgagcca 304921 ggcgcttgat atctatacga aatatgaact gtacggtcgc cgccgggttc agtgtgaatt 304981 tatcatcgcc ggaaatttga ccgatgtgta tcatcatgaa aaagcactga cccacttgtg 305041 cagcgcttta gaacatgcca ggcagcttga agaagcgtac atgatcgctg ctgcctatta 305101 taatgtcgga cactgtaagt acagtctggg tgattacaaa gaagcggagg gctatttcaa 305161 aacagccgcc gccatttttg aggagcacaa ctttcagcaa gctgttcaag ctgtattttc 305221 actgacccat atctactgta aagagggaaa atacgacaag gcagtagagg cttatgaccg 305281 cgggataaag agcgcggctg aatgggagga tgacatgtac ttgacgaaat tccgcctcat 305341 tcatgagctg tatcttggaa gcggcgacct gaacgtgctt acagaatgct ttgacctgct 305401 ggaatccagg cagcttcttg ctgacgccga agatctgctg catgatacag cggaacgttt 305461 caatcagttg gaacattacg agtccgccgc tttcttttac cgcaggctga tgaatattaa 305521 aaagaagctt gccgagcagc gttttcaata ggaaatggca gagaactaca ggttctctgc 305581 tttttttgtg ctgttttcaa ctcggaaaaa cagggtattt tccactgcat agtgagaaac 305641 agaggaggat atcaagtatg tacaaagatt taaccggaaa aacagcgatt gtgacagggt 305701 cttcaaaagg aatcgggaaa gccattgcgg aacggttcgg aaaggagaaa atgaatgttg 305761 ttgtaaatta ccacagcgac ccgtctggag cagatgaaac tctggaaatc attaagcaga 305821 acggagggaa agccgtctca gttgaggcgg acgtgtcaaa agaagagggg attcaggcgc 305881 tcttggacac agctttagag catttcggca cgctcgatgt gatggtaaac aactccggtt 305941 ttaacggcgt tgaggcgatg ccgcatgaga tgagtcttga agattggcag agagtgattg 306001 atgtcaatgt taccggaacc tttctgggag cgaaagcagc acttaaccac atgatgaaaa 306061 acaatatcaa gggcaatgtg ctgaatatct caagtgttca tcagcagatt ccgcgccctg 306121 taaacgttca gtattccaca tccaaaggcg gcatcaagat gatgacggaa acgctggcgc 306181 tcaattatgc ggataaggga atccgcgtca atgcgatagc gcccggcacc attgccacag 306241 aatcaaatgt tgatacgaaa aaggaagaga gcaggcaaaa acaattgaaa aaaatcccga 306301 tgaaagcctt cggaaagcct gaagaagtgg cggcagcagc agcttggctc gtatctgagg 306361 aagcaagcta tgtgaccggc gcaacacttt tcgtcgacgg cggaatgaca ctttatccat 306421 ctcagcttga atagaagaca aaacaggggg attgcgggat gaaaacagac tggtggaagg 306481 atgcagtggt gtaccaaatt tacccgagaa gctttcagga cagcaatgga gacggaattg 306541 gggacttgcg ggggattatt tcccgtcttg actacataaa ggagctcggg gcagatgtga 306601 tttggatttg cccgatctat ccttctccga atgttgatta cggctatgat gtgacaaacc 306661 ataaggcgat tatggattct tacggaacaa tggacgattt tcacgagctg ctggaccagg 306721 tgcatcagcg gggattaaag ctggtgatgg actttgtgtt aaatcacacc tcggtcgagc 306781 atccgtggtt taaagaagcg gagctggaca aaaacagcaa ataccgtagc tattattatt 306841 ggcgtcccgg cacaaagaac ggcccgccga cggactggct ctcaaactat ggatgcccgg 306901 tctggcaata cgaagagcac accggagaat actatctcca tatgaatgcc gtcaaacaag 306961 ctgatttaaa ctgggaaaat cccgaagttc gccaggcggt gtatgacatg atgaaatttt 307021 ggctcgataa aggggtcgac ggtttgcgaa ttgatcagct ccatctcatt tctaagaaag 307081 aatatcttcc ttcgtatgag gactatatca atcagcaggc agagccgaag ccctttcagc 307141 caaatggcga acgaatccat gactatttaa aagaaatcac agatgaagtg ttttctcatt 307201 atgatgtcat gtctgtcgga gaggtcggca gtgtcacacc ggaagaaggc ctgaaatata 307261 cgggaacaga taagcatgag ctgaatatga tttttcactt tcagcatatg gagcttgatc 307321 agcagcccgg aaaagaacat tgggatttga agccccttga gctttctgat ttaaaatcgg 307381 ttttgacaaa atggcaaaag aagcttgaac atcaaggctg gaatacattg ttttggtgca 307441 accacgacca gccccggatt gtgtccagat tcggagacga tggggaatac cgcaaagcat 307501 cagcgaaaat gctggcagcc gtaatttatt ttatgaaggg cacgccgtat atttatcagg 307561 gagaagaaat cgggatgaca aacgcgccgt tcacccggat tgaagactac aaagatatcc 307621 aaacgatcaa tatgtatcat aaacgggtgt ttgaaaaagg ctatgatcca aatgatgtga 307681 tgagatcgat cttagccaaa agccgggatc acgcccggac cccgatgcag tggaacagcg 307741 gcaaaaatgc cggatttact gacggcacgc cttggctgaa ggtcaatccg aacttcaccg 307801 caatcaatgt ggaggaagcg cagggagatc ctgattctgt cttaaactat tacaaaaagc 307861 tgatcagcct gagaaagcag tacgctgacc tcatgaaagg gagctttgat cttttgcttc 307921 cggacgatcc gcagttgttt gtatacatga gagaaaacag taaacaacag cttttgtcgg 307981 tcaataattt ttcaaaagag caggctgttt ttcagtggcc taagaactgc ggcaaagctc 308041 aggcctcact gcttctcagc aattataaca acgatgatct tgatgacgaa atggtgttcc 308101 ggccttatga gagcagggtc tatcttctgg acaaaacaaa ctaatgattg aagtagcccg 308161 gcatttttag ccgggttttt ttagtacata tattcgctct gcaggcggga agaataaatg 308221 aaaatgaaat ttattcttgc aaaacgtaat gacttcggtt tattatgata taggattaca 308281 aaatcgttat cattttgatt taaagttact gaaaaagagg ggatatacga tatgtttaaa 308341 aaatggagcg gtttgtttgt gattgcagcg tgctttttat tagttgcagc atgcggcaac 308401 tcatcaacaa aagggtcggc ggattcaaag ggtgataaac tgcacgttgt cacaacgttc 308461 tacccgatgt atgaattcac aaaacaaatt gtaaaagaca aaggcgatgt ggatctgtta 308521 atcccatctt ccgttgaacc gcatgattgg gaaccgacgc cgaaagacat tgccaacatt 308581 caggatgctg atttgttcgt ttataatagt gaatacatgg agacatgggt tccgtcagct 308641 gaaaaaagca tgggccaagg ccatgccgtt ttcgttaatg caagcaaagg cattgattta 308701 atggaaggct ctgaagaaga acacgaagag catgatcatg gggagcatga gcacagtcat 308761 gcaatggacc ctcacgtatg gcttagccct gttctggcac agaaggaagt taaaaatatt 308821 acggctcaaa tcgtgaagca ggacccggat aacaaagaat actatgagaa aaatagtaaa 308881 gaatatattg caaaactgca ggatcttgat aaactatatc gtacaaccgc aaaaaaagcg 308941 gagaaaaaag aatttatcac gcagcataca gcttttggct atctggcaaa agaatacggc 309001 ttgaagcagg ttccgattgc agggctttca cctgaccaag aaccgagcgc agccagcttg 309061 gcaaagctga aaacatatgc caaagaacat aatgtaaaag ttatttactt tgaagaaatt 309121 gcatcctcaa aggtcgcaga tacgctcgcc agtgaaatcg gcgcgaagac agaagtgctg 309181 aatacactgg aaggcttgag caaagaagaa caggataaag gtttagggta tatcgacatt 309241 atgaaacaaa acctcgatgc cctgaaagat tcactattgg ttaaatcata agatagtgtg 309301 cgccggaggg gtgcacacta tttctttgtg agaaaggaag attaacatga atctcgtctc 309361 attgaaagat atcgttttcg gctattccca tacgcctgtt ttagataaag tatcacttga 309421 tattgaaagc ggtgagttcg tcggcatcac tggaccaaac ggcgcctcta aatcgacgct 309481 cataaaggta atgctcggca tgctgaaacc gtgggaaggc acagtgacga tcagtaaaag 309541 gaatacagaa gggaaacgcc tgaccatagg gtacgtcccg cagcaaattt cttcatttaa 309601 tgccggattt ccgagcacgg tgctggagct tgttcagtca ggccgctata caaaagggaa 309661 atggtttaaa cgtttaaatg aagaagatca tcttgaagta gaaaaagcat tgaaaatggt 309721 ggaaatgtgg gacctccgcc atcgtaaaat cggtgattta tcaggcggac agaaacagaa 309781 aatctgtatc gccagaatgc tcgccagcaa cccggatctg ctgatgctgg acgaaccgac 309841 gacagctgtt gattacgaca gcagaaaagg attttacgaa tttatgcatc atctcgtgaa 309901 aaatcacaac cgcacagttg tgatggttac tcacgaacaa aacgaagtac agcaattttt 309961 agataaagtg attcgattag agagaggaga aaaaggcgga tggaaatgtt tgacttggaa 310021 ttcatgcgac gagcttttct agcaggcggc atgatcgccg tcatggctcc gatactagga 310081 gtgtatctcg ttctcagaag acaggcctta atggctgaca cactttcaca tatctcattg 310141 tcaggtgttg ccatcggctt ttttctcagc accaatataa ccgcagcaag catagtcgtc 310201 gtgaccatcg gcgcgatcgg aattgaatac atgcggcggg cgtatcggac ttattcagaa 310261 gtgtccattg ccatcttaat ggcagctggt ttgtccttcg cgatgttttt aatcagcctt 310321 tccaaaggca cagccaatat gagcatcgat caatacctat ttggatcgct tgtgacagta 310381 aaccagcagc aggtctatat tatcagtatt atcacactgc tgatcctgct ttattttatt 310441 gtactgagaa ggccgctcta cctgctgacg tttgatgaag ctacagccaa aacatcggga 310501 atcaatacaa acgttctctc gttgtcattc agtattgtca caggccttgc gatttcagtc 310561 attattccga tcatcggggt ccttcttgta tcggccctgc tcgtattgcc ggcagccttc 310621 gccatcagaa ttgcaaaagg ctttaacatg gttttcatta cagccatact catttcatta 310681 ttcagcgtat ttacgggact gacatcatcc tatcagctcg ggacgccgcc aggtccgtct 310741 attaccctgc tattgatcgt tttgctatta atcggatttg cagttcaggg agtttggacg 310801 tttatcaaaa aagaagctca gcgcaaaaaa agaagccgat aacatgaaaa gcagttttcc 310861 ctagggaaaa ctgctttttt tatagaaaca attcggcaag gcgctcataa gattcttttt 310921 tcgcctcaaa atcaaacaca ttgcacagaa ccatgatttc atttgtttcg tagcagcctg 310981 tgaggtctaa cagctgttgt ttgacagtgg tgggagaacc gatcaccatc cgctttctgt 311041 tttcttctat gagtttttta tcggacgctg tatagggatg agctttcgct tcctcgatgc 311101 ttggcacgcg gctgtccaag ccttttccga cgcgaagaag ccacagatcc tggcttaatg 311161 cgagttcttc tgcctcttca tctgtttttg cgcaaatgac aaaaatcgta aacagtgcgg 311221 atggattcga aaaatgggct gagggccgaa agctttcccg gtagatgcgg aatgcatttt 311281 ctcctcgctc gggattaatg aaatgcccaa atacatatcc aatcccctgg tgcgccgcgc 311341 gtcttgcgct gttttcacca agaccgagca cccatagctc gggtgccgta ccaataaggg 311401 gcgccgcttt gattccggca tacggatggt cgggaggaag ggaatctgtt agaaaataag 311461 agacatcctg cagctgtctg ttaaattcgg ttaagctttt tttcaccccg tccgttaatg 311521 caagtctggt ttttgtcgtg ccgccggggg agcgaccgac gccgaggtca atccggtttg 311581 gatacagggc ctcaagctgg cgaaaggttt cagccacttt aaatgggctg tattggggca 311641 gaagcacgcc gcctgatccg acacgaatgg tgtttgtctg tgctgcgatg cgggcgatca 311701 tgatttcagg cgctgtgctt gccagtcctt tcgtgctgtg atgctcggca aaccaataac 311761 gcttatagcc ccactgttcg cttaattggg caagctcaac cgaatgctgg agagttgtca 311821 cagggctttc tcctttagaa acaggtgcct gatcaagtat gcttaaatga atcaaaaggc 311881 cgcttccttt ctgtctgttt ttagatggtg acaccagaat aggcaaaatg acttgcccgc 311941 gtcaaatggt ttgtttaaga agcgcacttt atagcatttg caaatcatat atcaaatatg 312001 gaagtttttt ttcgaggttt ttcgtcaatt attcttaact tttacgaaac tttgatataa 312061 taacaaacgt atatattagt aatttacggc ttattttcct tgtgagcgta aaaataaatg 312121 tgactatctt cacattttga tgagtaggag tgaatcgtgt ggcaatttct ttagaaaaag 312181 gtcaacgaat tgatttaaca aaaggaaaag ccggtctgtc aaaattgatg gtcggtctcg 312241 gctgggaccc agtgtcctca ggcggaggat tcttcagcaa actgcttggc ggaggcggtc 312301 cgaatatcga ctgtgacgct tcagtgctga tgctggaaaa cggaaaattc accgataaga 312361 aaaacctgat ttatttcggc aacctgaaaa gccgctgcgg cggtgtacag catacaggcg 312421 acaacctgac gggtgacggt gcgggcgatg acgagcaaat tatgatagat ttagataaag 312481 tgcctggaaa catcgataag cttgtatttg tagtgaacat ttacgattgt gtcagaagaa 312541 aacaagattt cggcatgatt caaaatgcgt ttatccgcgt agttgatcaa tctaatcacg 312601 aggaaatgct caagtacaat ttgagagaca attacgccgg cagaacaagc ctgattacag 312661 cagaaatcta ccgcagcggc agtgagtgga agtttgcggc ggtcggtgaa ggcacaaacg 312721 atacgagatt agaagatatt atcagtcgat acgtataaaa gaaaaggagt ggatgaaaca 312781 tgacaatttc attggcaaaa ggacaaaaag tagatttaac aaaaacaaat ccgggtcttt 312841 caaaggttgt tgtcggttta ggctgggata cgaacaagta tgacggcggg cacgactttg 312901 atcttgactc aagtgtgttt ctgttagacg ccgcgggcaa atgcgcgtca ccaaacgact 312961 ttattttcta caaccagctt gaaggcggca acggttcagt cgttcattca ggcgacaacc 313021 tgactggtgc tggcgaaggc gacgatgaga atgtaaaagt aaatctcagc gctgtaccgg 313081 caaacattga taaaatctca tttgttatta ccattcacga tgcagaagcg cgcagccaaa 313141 actttggaca agtatcaaac gcgtttgtcc gcatcgtaaa tgaagaaaca aatgaagagc 313201 tcatccgtta cgatcttgca gaagatttct ctattgaaac ggcaatcatt gcaggggagc 313261 tttacagaca taacggcgag tggaaattct cagcaatcgg ctcaggctac caaggcggcc 313321 ttgcccgcat tgcaacagac tacggtttgc aagtcggtta agacaaatac gaagagcaga 313381 aaggagagag gcagtatggc cattcaatta tcaaaaggac agcgcattga tttaacaaaa 313441 acaaatccgg gactgactaa agcggtgatc ggcttaggct gggatacaaa caagtactcc 313501 ggcggacacg attttgacct ggatgcttcg gcctttttag ttgatgcgca tgataactgc 313561 gtaaatgatc tcgatttcgt cttctataat aaccttgaac atccgagcgg cggtgtcatc 313621 catacgggtg acaaccgcac gggtgagggc gacggagatg atgagcagat tatcgttgat 313681 ttctcaaaaa tccctgctca cattgagaaa atcggcatca cagtgaccat tcacgacgct 313741 gaagcacgca gccaaaactt tggacaagtt tccaatgcat ttgtccgcgt tgtggatgaa 313801 gaaacgcaga atgagcttct tcgcttcgat ttgggagaag acttctccat tgaaacagct 313861 gttgtcgttt gtgagcttta cagacacggc ggcgagtgga aattcaatgc aatcggcagc 313921 ggattttccg gcgggctggc tgcattgtgc cggaattacg gtttgcaagt gtaagcgagt 313981 gacaaataga gaagtcaccg tttcaaatta taggaggaaa aaacttggac tttttacatc 314041 atattttgtc tacgtatgct tcatttttcg attggaaaat gtggggggaa gttctgactg 314101 atcctgtttc ctggggtttg atcggttccc ttgttgttct ggaaggcctt ttatcggccg 314161 ataacgcgct tgttcttgcg gtcatggtta aacacctgcc ggaaaaacag cggaaaaaag 314221 cgttaacgta tggtttgttt ggagcttata ttttcaggtt tattttcatc gggctcggta 314281 tgcttctcat taaattctgg tggatcaagg tgcttggcgc gctttacctg gcttggctcg 314341 tcattaagca cttctggata ggcgaaaaag aagaggaagc ggacggcatg aagaaaaact 314401 cttggatggt ccgcacgttc gggatcttct gggcgactgt catttcagta gaattaatgg 314461 atcttgcctt ctctgtggac agcatcctgg ccgcgtttgc agtatctgaa aaagtatggg 314521 tgcttctgat tggcggtatg cttggtattt taatgatgcg tacagtggca aaagtgttcc 314581 ttgtgctgat tgataaaatt cctgagctgg aaaacacagc attcgtctta atcggcatta 314641 tcgcgctgaa aatggcgggg agcgctttcc attacgaaat gccgcactct gtattcttca 314701 ttatcattat cgctgcattt gcggtaacat tgatcattca ctacatcaat aaacaaaagc 314761 aggtgcgcga acaaacagcc gcttcaaaag aagaataaaa caaaacaagg agggaggttc 314821 aatgtccttc cttttttgtt accgaaatat cgtttcaatg acaaaccgga aaggaggata 314881 tgatgagaca agaagaacta accattcata aagcacttcc ggctgatggc gattggaaaa 314941 gcctgctgtt tcagccattg ccggagcggg atcactatga aactgcacaa ggcctttctt 315001 tttctcgtct tgccggtcag atattgggca cgcctattga tgagacggac tactataacg 315061 agctgtatga gctgtctgta aacgaccgca taacgatttt gagtgaaacg cttgataaaa 315121 caatcgaacc ggaaacattt caaaagcttc agcatattca ttccatcaat cagaaagaaa 315181 aagggctgtc agtcagccgc tttgttgcct ttctggacgg ggaaaagctg attgcgaagc 315241 actcaaatcc cttgatgcac cgccatttaa gaaaagcgtt gatgacgctt ttacatacct 315301 ttgcggacag tcatgaaaag gggctgaatc atcctgattt tcgcagagtg ctgcttgatg 315361 tctcgaagtt ttccttaaac catctgaacc cttggctgga aaaaaccgat atagagcggg 315421 agatgccgaa ggttgtttgg tatggagatg cgacgaaaag ccagctctat ttcttatatt 315481 atctgatgct ggtcggctgt gatgtactgc tgttccatcc ggcgggaacg gatcagctgg 315541 cgcttgtcga cccgaagcag gagctcggtt ttacggaaaa gctcccggat gtttcggagc 315601 ttcagccgtt tccgaaagaa aaaccagacc ggaaatcaac agtggcttac cgctcaacaa 315661 aggaaattga acatgtgctg aatcacgagg aatccatgct atataagccg tggcagttca 315721 gagatcacac accggtgtcc gttacgctga aaacgaccta tgatgaattg tttttaatca 315781 cgaaagaacg cgcctttatt cggccgaatt tcaaagctga taaacattcc attgagattc 315841 cgaatgtatt cgccaaaatt atgggcgtgt cgaaagacaa taaggaatat tggaacaggc 315901 ttcatactct agcggattat caggaaacag aaatggtcag aagctttcca tttacagaag 315961 aaataaagtc gaactatcaa tttcactaca gccacgcact tgatcaagaa gggaacattg 316021 atccggacaa gctgatggca agcaatgtgt ggcagtacaa acagctgccg gcgggcgttc 316081 agactgccat tgccaaaacg atttcgagaa tgtgcaggta cccgcggctt aaagccttgc 316141 atcaggaaca agtcaaggat gttcaaatct atttgtttaa acaaacaaca aacctgcctg 316201 ctaatctgct gaaattgatt caaatgttcg actatgcgca aaccgttccg aaactcgttt 316261 tatatcatac ggaaatgagc ggcggactca cgcgttcgga tgctgccgcc ctgctgttcc 316321 tgaatgaaat cggaatcgat atcatcattt ataatccgcc cggacaccaa gatattgagc 316381 agtttattga agaggatcag tatgatatcc actggctgga tgacatggtg tttcagcagg 316441 actacaaaga gccttcgctt gtgaaaaggc tcttcagaac cattacccaa aaataaggag 316501 agaagaaaag catgacaaca gaaaatcaaa atccgcttgt tctcgataaa aatgaagaga 316561 tttcccagca aaaagctgac gatatccgtc ttcagctccg tcaggaacca gaagtgaagc 316621 ggcttgctca acaaattgac gtcaaaaacc aaatggagct gcttgagtac ggcaaggagc 316681 cggccgttga aatatccaag ttctctgacc gcatcttggg gatgatgaaa acaacaagcg 316741 tgacagactc cggcacaatg ctgactcagc ttgggaaaat catggaccgc ttcgacaaaa 316801 atgattttga tgagccaaag ggattaatgg cgaaaatttt caaacgcggc ggcagcatga 316861 ttgaaaaaat ctttaaaaag tatcagacgc ttggcggaga gattgaaaaa atccacgttg 316921 agatttcaaa atacaaagat gagatgacga agacgaacta cacgctcgat gaaatgtatg 316981 aaaacaatat caaatactat atggagcttg aaaaatacgt cgttgccggg cagatgaaac 317041 tggaagagat gcagtcgatc cttccttcat atgaggaaaa agcggcaagc gggaaccagc 317101 tggcgcaaat gcagctcgat acgttgcgca acggcattca ggcgcttgag gaacgggtgt 317161 atgatcttga catggcacgg atggtggcgc ttcaaaccgc acctcaaatc cgtctcctgc 317221 agcgaggaaa tgcaaagctg atcgggaaaa tcaactccgc gtttatcatt accattccga 317281 ttttcaaaaa cggcattatt caggctgtta cggtaaagcg gcaaaagctt gtggctgatt 317341 ccatgagcga gcttgaccgc cggacaaacg agatgctgaa acgaaatgct gaaaacatct 317401 cgagccaaag tgttgaaatt gcgagaatgg ccggcagacc gagcatagat attgaaacga 317461 ttgaatcgtc ttggaacacg attgtcagcg gcatgcagga aacaaaacaa atcgaagaag 317521 aaaacaagcg cctccgcgaa gacggcgcga gacgaattgc ccagcttcag gataatatta 317581 aaaaagcagc attgcagcaa taataaaaac cccgcttgtg gaacataagc ggggtatttc 317641 aattacatca tttagttaat gacaatgtgt aaagacaggt gtaaacttaa acggtaatca 317701 ttttgcatat cagaggtgtt ggcaatggga aaacaacagc ctatatccca gcgtaaactg 317761 ctgggcgtcg ccggtttggg gtggctgttt gatgcaatgg atgtcggaat attatcgttt 317821 attatcgccg cgctccatgt agagtggaat ctgtcgcccg aagaaatgaa atggatcgga 317881 agcgtcaatt ccatcggcat ggctgcgggt gcgtttttgt ttggtttgct tgctgatcga 317941 atcggccgca aaaaagtgtt catcatcacc cttttatgct tttccatcgg aagcggcatt 318001 tccgcttttg tgacgagctt atcggcattt ctaatccttc gtttcgtgat tggtatggga 318061 cttggcggcg agcttccagt cgcttcaaca ctcgtttcgg aagcggttgt gcctgaaaag 318121 cggggcagag tgattgtgct tttggaaagc ttttgggccg tgggctggct cgcagcggcc 318181 ttgatttctt actttgtgat accaagcttc ggctggcagg ctgcccttct gttaactgcg 318241 ctgactgctt tttatgcgct gtacctgcgg acgagtctac ctgattcgcc gaaatatgaa 318301 tcgctttctg ccaaaaagag gtcgatgtgg gagaatgtaa aaagcgtctg ggcaagacag 318361 tatatacggc cgacggtgat gctgtcgatc gtttggttct gtgtggtgtt ttcttattac 318421 ggcatgttcc tatggctccc gagtgtcatg ctgctgaaag gcttcagcat gattcaaagc 318481 tttgaatatg tcctgctgat gacgcttgct cagctacctg gctatttctc tgccgcatgg 318541 ctgattgaaa aagcgggccg gaagtggata ctcgtcgttt acttgattgg cacagcagga 318601 agcgcctatt tcttcggaac ggcggattcc ttaagtcttc tgcttacggc tggagtgctg 318661 ttatcgtttt tcaatctcgg tgcgtggggc gtgctgtatg cttatacccc ggagcaatac 318721 ccgactgcga ttcgagcaac aggttcagga acgacagcag cgtttggaag aatcggcggc 318781 atcttcgggc ctttgctcgt cggaaccctg gcagcccgtc atatttcgtt ttcggtcatc 318841 ttttcaatct tttgcattgc aatcttactt gcggttgctt gtattttgat tatggggaaa 318901 gaaacgaaac aaactgagct agaataggaa aagcacctct taaaagaggt gctttcagcg 318961 tgtcgacaaa ccctcgcatt cgttgtcagg actgcgcttc ggtgctcaat gcgaagtgga 319021 tcaacggcta aattctcagg cgtcctgcct aaacgccgtc gtcatcacat cctgtgaatg 319081 tccgctccta tgctcgtcct tcctagactt caagggtttt caatcacgct gaaaagattt 319141 tgtcaacaat ctgaggcacc tcttgaatga ggtgcttttt tacaattgcg cccgggctgt 319201 ggattggcgt ttcccggttt tactgattgt ctggtagagc gtcatagaaa gtatgaacag 319261 aatggcagta aatcctgtga cagctccgaa atgctgtgtg ctttgatata aaaaacctgc 319321 aatacttgta ccgacagtgg ttccggcata catagcggca ttggaaaggg aagcgatggt 319381 tcctcgcgca tttggtgcaa tggattgaaa gacacccatc attaacggaa agatgatgcc 319441 agctgtaaag aacgtgagaa aaaagccggc ttctactaaa aacaagtttg gaaagaacgg 319501 aagagcgaaa tagagagcgc ccattagcag catcccgctg atcagtgttt taaacatgcc 319561 cagcttttct gaaacccggc tgccgataag gctcccgagc atatttccca gtccgagtac 319621 aagcatagct gcgccaattt gtgacacggt taaatgataa tccgcggaaa gccaagtacc 319681 cagaaagctg aacgatgcga agtttccggt ttgaaacaga aaataggcaa gcagaatgac 319741 cgatgttttc ggcaatgaaa aaagctcccg ataggggttg acaattgatg ggcgcgccaa 319801 tggttcagaa ggccggatgc caggcatgac cgccgccagg atcaatagaa gaataagcga 319861 gcacgctgac aaaacgaaaa atggcgtatg ccatgtaaag gaagcgagaa accctccaat 319921 aggaagtccg agcatttgtg aagcggccaa acctgctgtc gcaatcccca tgccttttat 319981 gatctgagaa ggctggacaa tgactgggat ggacgcccaa atttgaggcg tcacaaacgc 320041 agcgctaacg cctgcggcaa aacggaacag gcacatggcg gcaaaagagg gagcgatgcc 320101 gcataaaaat gtggatacga taaagcctgc aagtccccac agcatgactg ttttcctgtt 320161 cagccggtct gagattgggc ctgcaatgaa agcgaagagt gcataaccga gtgcataagc 320221 actgaccatc cagcctgaca aatcagtaga gacatgaaac tgatcctgta aaagggggag 320281 aagcggcgaa agcaaaaagg tatccgtgcc aatgacaaac atgacactga agaaaagcca 320341 aatgcgattc aaattttatc actcctattg ttttataact ttaaaactat gaaacagata 320401 tgtatagaga aaaccctttg ttagagggtt tccaaaaagc caggcaggta tgtttgaaat 320461 gtgtcttcac gcagactgac gtattttgtc cgcgaatctt tccgggttgc cgtcaatccc 320521 gcttcacgca gcgttttaaa atgataagat gccgtggttt tgacaatatt gcacttttca 320581 cctacttcac cgcagctgag ttcttttccg ctgacataaa gcgtacgaat aatggcaagc 320641 cttgattcat cagacagtgc tttaaaaatt tgcgctctga tttgatcatc tgattgtttc 320701 atagtcatga aactataata cataatgggt gttgaaaaag caacttattt ttccagtaaa 320761 ggagcaggaa gtcataagag gaaggaggaa ttcaattcca ataaaagcgt tttcaactaa 320821 aggtaggaga aaaatcaccc gtaaaataca atcatatagg aggattacag agcatttaga 320881 agcataaata agatcatgtg gtcacatgga tgtttataaa gaaatggtac agaataaaag 320941 agaatatgct gtttgtgtgg gaagttacat aaatgttacg gtaataaaga ttgcttaata 321001 tggagggaaa atatgagtgt agatgagaaa ccaattaaga taaaagtcga gaaagtctct 321061 aagatttttg ggaaacaaac aaagaaggca gttcaaatgc ttgccaacgg aaagacaaaa 321121 aaagagatcc tgaaagcaac cggatcaacc gttggggtta atcaggcaga ttttgaagta 321181 tatgatggtg agatatttgt catcatgggt ctatcaggga gcggtaaatc aactttagta 321241 cggatgttaa accggcttat tgaaccgact gccggaaata tttacattga tggtgacatg 321301 ataacaaata tgtcaaaaga ccagctccgg gaagtccgcc ggaaaaaaat cagcatggtc 321361 ttccaaaagt tcgctctgtt tccgcacaga acgatacttg aaaacacaga atacggactg 321421 gagcttcaag gtgtagacaa acaagagcgg cagcaaaaag cgcttgagtc tcttaagctc 321481 gttggactgg aaggatttga acaccaatat cccgaccagc tttccggcgg gatgcagcag 321541 cgtgtcggcc ttgcccgcgc gttgacgaat gacccggaca tccttctgat ggacgaagcg 321601 ttcagtgcgc tcgatccact gattcgtaaa gatatgcagg atgagcttct tgatcttcac 321661 gataatgtcg gaaaaacaat tatctttatt acgcatgact tggacgaagc gttgcggatc 321721 ggcgacagaa ttgtcctaat gaaggacggc aacatcgttc aaatcggcac gcctgaagaa 321781 atcctgatga atccatctaa cgaatatgtt gagaaattcg tcgaagatgt tgatttgtct 321841 aaagtcctca cagcaggcca cattatgaaa cgcgctgaaa cagtgcggat tgataaaggg 321901 cctcgcgtag cattgacact gatgaaaaac cttggaattt cttcaattta tgcagtggat 321961 aaacaaaaga aattattagg tgttatctat gcgtctgatg cgaaaaaagc ggctgagtct 322021 gatttgtcac ttcaagacat cttgaataca gaatttacga ctgtaccaga gaatacgtat 322081 ctgactgaga tttttgacgt tgtgtccgat gcgaatattc caattgcggt tgtggatgag 322141 aagcaaagaa tgaaaggaat tgtcgtaaga ggcgcgctga ttggcgcact tgccggcaat 322201 aacgagtata tcaatgctga aggcactaac gaacaaacac aagatccttc tgcacaggag 322261 gtgaaataag atggatagac tgcctagaat acctttagca gatattattg accgttttgt 322321 tgactggatt acgatgacgt ttggcggatt cttcgacgga atcgctaacg gattggccgc 322381 ttttgtaaat ggaattgtca ccggtcttgg atttattcca tctattttgt taacgattat 322441 tttcgccgca cttgcgtggt ggatcagtac aaggggaatt gcgttattta cgttgattgg 322501 attcctcctg atcgattatt taggatattg ggacccaatg ctgcaaacat tggcgcttgt 322561 tttgacatct gtgattattt cgattgtggt cggggttccg atcggaattt gggcgtctca 322621 gaaagaaacg gttcgccgta ttgtaacgcc aattcttgat ttaatgcaga caatgcctgc 322681 tttcgtatat ctattgccgg cgattttctt ctttaacatc ggtgttgtgc cgggtgttgt 322741 tgcatctgtt atcttcgcga tgccgccgac aatccgcatg actgttctcg gtattaaaca 322801 agtgccggcg gatttgattg aagcgactga ggcattcggt tctacaacag ctcagcgttt 322861 gtttaaagtt cagctcccgc ttgcgacaaa aacgattttg gccgggatca accagagcat 322921 catgcttgcg ttatcaatgg ttgttatcgc cgcaatggtc ggtgcaccgg gacttggttc 322981 tgaagtatac agtgccgtta cacagctgaa aaccggggtc ggagtagagg ccggtatcgc 323041 catcgttatc gttgccatta ccctggaccg tattactcaa aatattaaag tgaagaagaa 323101 aagcaggggg aatgcctgat gcttaaaaaa atcataggca tcggcgtttc cgccatgctg 323161 gcgctctcac ttgcggcttg cggttcagaa aacgatgaaa atgcatccgc agcagaacaa 323221 gtgaataaga ccatcatcgg gattgacccc ggttcaggga ttatgtccct gactgacaaa 323281 gcgatgaagg attatgacct gaatgactgg acattgattt cagcgtcaag tgctgcgatg 323341 accgctacgc ttaaaaagtc atacgaccgt aagaaaccga ttatcattac aggatggaca 323401 ccgcactgga tgttctccag atataagctg aaatatctcg atgatccgaa acaatcttat 323461 ggcagcgcag aggaaatcca tacgatcaca cgcaaaggct tcagcaaaga gcagccgaat 323521 gccgcaaagc ttctgagcca gtttaaatgg acgcaggacg aaatgggcga aatcatgatc 323581 aaggtggaag aaggcgagaa acctgccaaa gttgctgctg agtacgtcaa taaacacaag 323641 gatcagattg ccgaatggac aaaaggcgtt caaaaggtga agggagacaa aatcaacctt 323701 gcctatgtgg cgtgggacag tgagattgca agtacaaacg tcataggcaa agtcttagaa 323761 gacttgggct atgaggtaac acttactcag gtagaggctg ggccgatgtg gactgcaatt 323821 gcgacgggaa gtgcggatgc atccctttcc gcatggctgc cgaataccca taaagcatac 323881 gccgctaaat ataaaggcaa atatgatgat attggcacca gtatgactgg tgtgaagatg 323941 gggcttgttg ttcctcaata tatgaaaaat gtcaactcaa ttgaagattt gaagaagtaa 324001 tcaaaaaagc agcctgtgtc aggctgcttt ttttgcgtta agaagcgtta gcggcagcaa 324061 gtgattccgc cttctgaaat gttttgagca cggcgttcgc caaaatatga atgccggtaa 324121 acatcgcatt tctgtcaaag gtcatgtgcg gatgatggag ccccggctgg agcccgcagc 324181 ctagtccgag catcgttgtt ttcagattcg gcaccttcac ggcgtaaaaa tggaaatcct 324241 cgccgccggt ggtgacaagc gggtcatcaa gccgctcagc cccgatgatt tccgtaatgg 324301 cttctgccat gatcgcttca gcttctttat tttgtgttgc cgcaggaagg ctgtgttctt 324361 tgtgcagctc gatctttgcg ccaaatgcag cggcggccgc ttcacaggct ctttctgttt 324421 cggcgattaa tgcctccatg gcttcattgg tctgtgcgcg caaatcaagg ctgaacgatg 324481 cttttcctgg aatgatgtta gagctttcac cgccggcttg cagttttgtc attttgacgg 324541 tatgcgggat ttgcgggtca atatgaatga gtccgagctt gtgtacaaga aatgccgcaa 324601 tttcaatgct gtttttcccg aggtgcggac gggcgccatg agcctcttcc ccgatgatcg 324661 ttccctcaat gtgctggctt gatccgtgca gaatagaagg agcgcagcgg ccgttctgtg 324721 tttcctggat cggacggacg tgaacgccat acaaatagtc gatatcatca agcacgcctt 324781 cttctatcat tttcaaggcg ccgccgcctt tttcttctgc cggctgaaag ataaaacgga 324841 ttgtgccctt cggaagctca ggttgttttt ttagcagcat taacgtgccc aatgccattg 324901 tcatatgtga atcgtgtccg caggaatggt tggcgcgaaa tgtgccgtta acctcctgcc 324961 acagcgcgtc aatatcagcg cgtaccgcta caacaggtga gcctgagccg atttcgccga 325021 caaccccggt gcagtctgaa aacgtgcgcg tccggcaccc taaatcctca agcttttgtt 325081 tcaaaaatga agttgtctca tattccttcc agctgacttc agggttcgcg tgcagatgct 325141 cgaagatgtc cataatggtt tgtttcattt cttctgaaag cttttgcatg gtaagaaata 325201 cctccttcta tcagaatgaa tttttacctt ctttacttta tttatattga aacaggaaga 325261 taggctgtat ataatatagc acatattgct actattcaga ataattaata ttttcaaaca 325321 gaggggatgg atcgaaatat gagtatgcca gcagccgaaa cacagcctaa gaaaaaacgt 325381 atgacattta aaatgcctga cgcctatgtc ctcttattta tgattgcttt catttgcgca 325441 atcgcttcat atattgtgcc ggcaggtgaa tttgaccgcg tgacaaaggg ggatgtcacg 325501 accgctgttc cgggaagcta tcattcaatt gaacagtctc cggtcagatt gatcagcttt 325561 tttacttctc tacaggatgg aatggttgga tcagcaccca tcatctttct gattttattc 325621 acaggcggca ccattgctat tctagaaaaa acgggtgcca tcaatggcct gatttacaat 325681 gtcatcagca aattccgcac aaagcaatta ttatttattt gtattgtcgg cgcattgttc 325741 tccattctcg gaacaaccgg gattgtcgtg aattcagtta tcggttttat ccccatcggc 325801 ctcattgtgg cacgatcctt aaaatgggac gcagtcgcgg gagccgctgt tatatacatc 325861 ggctgctacg ctggatttaa ctccaccata ttatcaccgt caccgctcgg tttatcacaa 325921 tcaatcgcgg agctccctct tttctcagga atcggcctgc gagttgtgat atacatatgc 325981 tttttgctgt cttctattat ttatatctat ttgtatacga gaaaattaaa aaaatcaaaa 326041 gatgccagtg tgttaggaac agattggttc cctgcggcag gaatgggcga agccggtaaa 326101 gaagaagatc agtcagtgcc gtttaccgtt cgccataagc tgattttggc tgtggcggga 326161 ctctcacttg tcggattttt atacggcgct ttgaagcttg gctggtcaga ttcccaaatg 326221 gctgcgacat ttatttttat ttctgtcctt gccggtttaa taggcgggct tgcggcgaac 326281 gatattgcca aaaccttcat tacgggctgc caaagtcttg tatacggggc gctgattgtc 326341 gggatggcac gaagcatttc cgttatcctt gaaaatggaa agcttctcga tactgtcgtc 326401 aatgctttgg cttcactttt ggatggattc agcccgattg ctggggcaat cggcatgtat 326461 atcgccagtg cgctgcttca ttttctcatc tcttcaggtt ctggcgaagc cgttgtattt 326521 attccaatcc tggcgccgct cgctgatttg atgggaatca cgagacaggt tgcggttgaa 326581 gcggttatgc ttggagaagg ggtcgtcaac tgtgtgaacc cgacatccgg cgttctcatg 326641 gcggtgcttg ccgccagcgg tattccgtat gtcaagtggc tgcggtttat ggtgccgctt 326701 gctctgattt ggttcttgat cgggcttgtc tttatcgtga tcggagtcat gatcaattgg 326761 gggccgtttt aacgattgct gcccgccggc ttgtacggcg ggcttttgag ttattcattg 326821 cagaagcgca ggctgttatt gtaacatgta agccataagc cattcgtaaa agtgcgggag 326881 gaaggtcatg aataatctgc gtaatagact ttcaggcgtg aatgggaaaa ataagagagt 326941 aaaagaaaaa gaacaaaaaa tctggtcgga gattgggatg atagcgggag catttgcgct 327001 gcttgatgtg atcatccgcg gcattatgtt tgaatttccg tttaaagaat gggctgcaag 327061 ccttgtgttt ttgttcatca ttatcttata ttactgcatc agggctgcgg catccggaat 327121 gctcatgccg agaatagaca ccaaagaaga actgcaaaaa cgggtgaagc agcagcgaat 327181 agaatcaatt gcggtcgcct ttgcggtagt ggtgcttacg atgtacgaca gggggattcc 327241 ccatacattc ttcgcttggc tgaaaatgat tcttcttttt atcgtctgcg gcggcgttct 327301 gtttctgctt cggtatgtga ttgtgaagct ggcttacaga agagcggtaa aagaagaaat 327361 aaaaaagaaa tcatcttttt tgtttggaaa gcgagggaag cgttcacagt ttcgggcagc 327421 tttttttata ggaacattga tttgtattca ctctgccaag ttgttttgat agagtgattg 327481 tgataatttt aaatgtaagc gttaacaaaa ttctccagtc ttcacatcgg tttgaaagga 327541 ggaagcggaa gaatgaagta agagggattt ttgactccga agtaagtctt caaaaaatca 327601 aataaggagt gtcaagaatg tttgcaaaac gattcaaaac ctctttactg ccgttattcg 327661 ctggattttt attgctgttt catttggttc tggcaggacc ggcggctgcg agtgctgaaa 327721 cggcgaacaa atcgaatgag cttacagcac cgtcgatcaa aagcggaacc attcttcatg 327781 catggaattg gtcgttcaat acgttaaaac acaatatgaa ggatattcat gatgcaggat 327841 atacagccat tcagacatct ccgattaacc aagtaaagga agggaatcaa ggagataaaa 327901 gcatgtcgaa ctggtactgg ctgtatcagc cgacatcgta tcaaattggc aaccgttact 327961 taggtactga acaagaattt aaagaaatgt gtgcagccgc tgaagaatat ggcataaagg 328021 tcattgttga cgcggtcatc aatcatacca ccagtgatta tgccgcgatt tccaatgagg 328081 ttaagagtat tccaaactgg acacatggaa acacacaaat taaaaactgg tctgatcgat 328141 gggatgtcac gcagaattca ttgctcgggc tgtatgactg gaatacacaa aatacacaag 328201 tacagtccta tctgaaacgg ttcttagaca gggcattgaa tgacggggca gacggttttc 328261 gatttgatgc cgccaaacat atagagcttc cagatgatgg cagttacggc agtcaatttt 328321 ggccgaatat cacaaataca tctgcagagt tccaatacgg agaaatcctg caggatagtg 328381 cctccagaga tgctgcatat gcgaattata tggatgtgac agcgtctaac tatgggcatt 328441 ccataaggtc cgctttaaag aatcgtaatc tgggcgtgtc gaatatctcc cactatgcat 328501 ctgatgtgtc tgcggacaag ctagtgacat gggtagagtc gcatgatacg tatgccaatg 328561 atgatgaaga gtcgacatgg atgagcgatg atgatatccg tttaggctgg gcggtgatag 328621 cttctcgttc aggcagtacg cctcttttct tttccagacc tgagggaggc ggaaatggtg 328681 tgaggttccc ggggaaaagc caaataggcg atcgcgggag tgctttattt gaagatcagg 328741 ctatcactgc ggtcaataga tttcacaatg tgatggctgg acagcctgag gaactctcga 328801 acccgaatgg aaacaaccag atatttatga atcagcgcgg ctcacatggc gttgtgctgg 328861 caaatgcagg ttcatcctct gtctctatca atacggcaac aaaattgcct gatggcaggt 328921 atgacaataa agctggagcg ggttcatttc aagtgaacga tggtaaactg acaggcacga 328981 tcaatgccag gtctgtagct gtgctttatc ctgatgatat tgcaaaagcg cctcatgttt 329041 tccttgagaa ttacaaaaca ggtgtaacac attctttcaa tgatcaactg acgattacct 329101 tgcgtgcaga tgcgaataca acaaaagccg tttatcaaat caataatgga ccagagacgg 329161 cgtttaagga tggagatcaa ttcacaatcg gaaaaggaga tccatttggc aaaacataca 329221 ccatcatgtt aaaaggaacg aacagtgatg gtgtaacgag gaccgagaaa tacagttttg 329281 ttaaaagaga tccagcgtcg gccaaaacca tcggctatca aaatccgaat cattggagcc 329341 aggtaaatgc ttatatctat aaacatgatg ggagccgagt aattgaattg accggatctt 329401 ggcctggaaa accaatgact aaaaatgcag acggaattta cacgctgacg ctgcctgcgg 329461 acacggatac aaccaacgca aaagtgattt ttaataatgg cagcgcccaa gtgcccggtc 329521 agaatcagcc tggctttgat tacgtgctaa atggtttata taatgactcg ggcttaagcg 329581 gttctcttcc ccattgaggg caaggctaga cgggacttac cgaaagaaac catcaatgat 329641 ggtttctttt ttgttcataa atcagacaaa acttttctct tgcaaaagtt tgtgaagtgt 329701 tgcacaatat aaatgtgaaa tacttcacaa acaaaaagac atcaaagaga aacataccct 329761 ggaaggatga ttaatgatga acaaacatgt aaataaagta gctttaatcg gagcgggttt 329821 tgttggaagc agttatgcat ttgcgttaat taaccaagga atcacagatg agcttgtggt 329881 cattgatgta aataaagaaa aagcaatggg cgatgtgatg gatttaaacc acggaaaggc 329941 gtttgcgcca caaccggtca aaacatctta cggaacatat gaagactgca aggatgctga 330001 tattgtctgc atttgcgccg gagcaaacca aaaacctggt gagacacgcc ttgaattagt 330061 agaaaagaac ttgaagattt tcaaaggcat cgttagtgaa gtcatggcga gcggatttga 330121 cggcattttc ttagtcgcga caaatccggt tgatatcctg acttacgcaa catggaaatt 330181 cagcggcctg ccaaaagagc gggtgattgg aagcggcaca acacttgatt ctgcgagatt 330241 ccgtttcatg ctgagcgaat actttggcgc agcgcctcaa aacgtacacg cgcatattat 330301 cggagagcac ggcgacacag agcttcctgt ttggagccac gcgaatgtcg gcggtgtgcc 330361 ggtcagtgaa ctcgttgaga aaaacgatgc gtacaaacaa gaggagctgg accaaattgt 330421 agatgatgtg aaaaacgcag cttaccatat cattgagaaa aaaggcgcga cttattatgg 330481 ggttgcgatg agtcttgctc gcattacaaa agccattctt cataatgaaa acagcatatt 330541 aactgtcagc acatatttgg acgggcaata cggtgcagat gacgtgtaca tcggtgtgcc 330601 ggctgtcgtg aatcgcggag ggatcgcagg tatcactgag ctgaacttaa atgagaaaga 330661 aaaagaacag ttccttcaca gcgccggcgt ccttaaaaac attttaaaac ctcattttgc 330721 agaacaaaaa gtcaactaac cgcaacttta gagtaaaggg ctgattgtca atgtgggagc 330781 agttgtatga tccgtttgga aacgagtatg tgagcgcact tgtggcgctc actccgattc 330841 tcttttttct tttggcttta actgttttga aaatgaaagg cattcttgcg gcatttctta 330901 ccctagccgt cagtttcttc gtctccgttt gggcatttca tatgccggtt gaaaaagcga 330961 tttcttctgt tttgttagga atcgggagcg ggctgtggcc cattggctac atcgtcctga 331021 tggcggtgtg gctgtataaa atcgccgtga aaaccgggaa atttaccatt attcggtcca 331081 gcattgccgg catttcgcct gaccaacgat tacagctatt attaattggt ttttgtttta 331141 acgcgttttt agaaggcgcg gccggttttg gtgttccgat tgcgattagt gcggcgctgc 331201 tcgtcgaact tggttttaaa ccgttaaaag cggcggcgct ctgcttgatt gcaaacgctg 331261 cctccggagc ctttggggcg attgggattc ctgtcatcac aggggcgcag attggtgatt 331321 tgtctgctct tgagctgtct cggacattaa tgtggacact gccgatgatc tcatttttaa 331381 taccattcct gcttgtattc ttattagacc gaatgaaagg aatcaaacag acatggcccg 331441 ctcttctggt tgtgagcggt gggtatacag cggttcagac actgacaatg gcggtgctcg 331501 ggccggaatt agcaaacatt ttggcggcct tattcagcat gggcgggctt gccctcttcc 331561 tccgcaaatg gcagccgaaa gagatttacc gcgaggaagg ggccggcgat gctggtgaga 331621 aaaaggcata ccgtgccgct gacattgcga aagcgtggtc tcctttctac attttaactg 331681 cggcgatcac catctggagc cttcctgcct tcaaagcgct tttccaagaa ggcgggctgt 331741 tatatcaatc aacgctcctg ttcaaaatgc cttttctgca tcagcaaatt atgaaaatgc 331801 cgccgattgc gccatctgcc atgccgttag atgcagtctt taaagttgat ctgctgtcag 331861 cgactggtac agcgatttta gcggcggtca tcgtgacagg gctgttcagc aaaaagttct 331921 cctctcggga tgcctttgct tccttgaagg agacgggaaa agagctgtgg gtgccgatta 331981 tgacgatctg cttcgtgatg gggtttgcca atctggccaa cttcgcaggg ctcagctctt 332041 caattgggtt agcattggcg aaaacaggag acctgttccc gtttgtcagt cctgttctcg 332101 gctggattgg cgtgttcatc accggttctg ttgtcagcaa taatgctttg ttcggccatt 332161 tgcaggttgt cacgggagcg cagatcggtg cgggttcaga tttgctgtta gccgcaaata 332221 cggcgggcgg tgtcatggcg aaacttgttt ctcctcaatc tatcgccatc gctgccgcag 332281 cggtcggcca aacaggcaag gaatctaaac tgtttaaaag gacagtggcg tacagcctga 332341 ttctgttatt gatcatttgt atatggacgt ttattcttgc aagattagga gtgtaataga 332401 aaaaagcagt acatgcccag catgtactgc tttttttatg ttaatttgct ttctttgtca 332461 tttcggctgt tgttttcact ctggcttttc ccataaataa aatggtaacc gccgcgagga 332521 caattggaat caaagcgagc aaaaagacat acgtgatact tgatgacatc gcgtcaataa 332581 tgcgattcag gatcgcatca ggaatctggg aacgtgttcc cgcttggaat atctcctgcg 332641 ggtcgccaat attttgcgca gcgcctgatc ccgctgagcc tttcataccg ctgaaggcgt 332701 cattcagctt gtttgtgaat acgtttgttt gcaccgttcc gaaaatggtg acacctaagg 332761 tcatgccaaa tgatcgcaaa aatgaatttg tagagtttgc cgttccccga aagcgaggtt 332821 caagatcatt catcgatgcc gccggcagca gggagaagtt aaagcctaca ccaaagcctg 332881 aaatcatcat aaagactgtc agccataccc gtgctgtgtc aggcgtcata ttggaaagaa 332941 gcagcatgcc gataaagaaa gctataacag atatcagcat caaattgcgg aagcttgcct 333001 tcgtttggaa gatcccgccg atcatgcttc cgatgactga tccaatcatc atcggcgtca 333061 gaatgaagcc cgcgcttgtc gccgagctgc cgtagaccgc ctgaacgaaa atcggaataa 333121 ataccgctaa aataataaat gttccgccat acaggaaagc gagaatctgt gctgtggcaa 333181 acaagcggtt cttaaacatc cagaaagaaa taatcggctc ttctgctttt ctctccacaa 333241 taaaaaaggc aatgaagaaa acggcgaata caataaacag cccgatgatc tgaatggagt 333301 tccaatcgta tgttttgccg ccaagctcaa gggcgaacat caggcataca atggatacga 333361 ctaaggtaat cgcgccgccc cagtctattt tctgctttct gtgctccaga gattctttgt 333421 agtagcgaat aatgaaaaac aatgacaatg cgccgatcgg cacattgatg taaaacaccc 333481 agtgccagct gatcgaatct gtaatgatcg cgcctaagag cggaccaaga acactggata 333541 atccaaatac agcaccgaac atgccggaca tttttccgcg tttttccggc ggaaacaaat 333601 caaagataat ggtaaaggca atcggcagga gcgcgccgcc tccgatccct tgaatggccc 333661 ggaagatgat cagctgattc atcgtctggg caatcccgca taaagcagaa ccgattaaga 333721 aaaaaataag tccaaacagg aaaaaacgtt ttcggccgta catatcggaa agcttgccgt 333781 aaatcggcat gccagccata accgccacca tataggatgc cgtcacccag gcaaatttat 333841 cgaagcttcc aagatcggct acgatattgc ccatcgcggt ggcaacaatc gtattgtcca 333901 ttgcagacat caagatgccc agcaggagac cgaggaccac aaatttggtg gaagcctgtt 333961 ttgctgttgt tgtgtccatt tgttctacct cctcttactt ttctatgtaa gttctgatat 334021 catgataata gtttgattgt tgaatatctc gattatcaag ataaactcga ttttataggg 334081 aggactgtca gttgtcaaca agaaattcca gaagtgagtt ggaaaagact gctgttcagc 334141 tttttcgaaa actgggcaca agaacggttc tgtttcatca ggcagccgct caagctctcg 334201 gtctgtttcc caccgatttg aaatcagctg acattttaaa tgaagcaggg ccgatgacgg 334261 ccggagagct ggggaaaaaa accggcctca gcacgggttc cgtcacggcg cttgttgacc 334321 ggctggaaaa agcggggtat gtggctcgtg aaaaggaccc gaacgatcgc aggagagtcg 334381 taatcgtccc tttgactgct tcgaaaaaac atataaagga tttgttccgt cctctgtctg 334441 agtcaacgat ggatttgtgc cgcgaatata cggaagagga gctggaactc attttcagtt 334501 ttgtaggcaa agctgccgat attatggagg aagagcttga acgtctgaaa cagtaagtga 334561 atttgtgcat agcttggccc gttcccgaat aaattgtaca agttacataa gagaagggag 334621 tacgggccgg tgaacatttt tttgagctat attgtgctgg gactgtcctt gtctgcgcct 334681 gtggggccag tgaatgcggc gcaaatagac aaaggaatta aaaacggttt ttggcatgca 334741 tggattttcg gtttaggcgc catgacagcg gatgggctgt acatgctttt tatctatttc 334801 gggctgtcgc agttcttgac cgctccattt gtgaaaacgt ttttgtggct gttcggcttt 334861 tttgtcctga cctataccgg aattgaaacg ctgaaaaacg tcagagaacc gatggatgtg 334921 cgaagctcgc gggggaaacc gtcatacagg aaaacattcg catcgggttt tctcatttca 334981 ttgtcaaacc cattgagcat ccttttttgg cttggaattt acggaagcat tcttgcgaaa 335041 acagcagagg cctacaatat gaatcagctt ctaatctata gctccggcat catgatcggc 335101 attttaatct gggatttctg catggctatc acagccagta cgttcagaaa cctgcttcat 335161 gaaaagctat tgagaggatt gaccggaatc gccggtgtat ccctccttgt gtttggcttt 335221 tactttggtt atcagggcat caaacagtta ttgggctgat tcatgaagga cagtcacctg 335281 ccgcttccag ttttaatata gtatccagat gatactggag gtggatcaat ggtgaatggg 335341 atttacacca aaagttttct ggaacgtatt caggaagagc ttcctgaatg gcaaagaatc 335401 gcttttgagc tgctggcaga aactctgggg gacgacgcgg atacatttcc gtgcattccc 335461 ggacgccagg cgtttctgac tgatcagctt cggattgctt ttgccggaga tccgcgggaa 335521 aaccgcacag cggaggaact ggctccgttg cttgcggagt acggcaagat atcgcgggac 335581 acgggaaaat acgcatccct cgttgtgttg tttgatacac cggaagattt ggcggagcat 335641 tattcgattg aagcgtatga agagctgttt tggcgctttt taaatagact gagtcatcaa 335701 gacgaaaaag aatggccgga agacattccg gccgatcctg agcattataa atgggagttt 335761 tgttttgacg gcgagccgta tttcattctg tgcgctacac cggggcacga ggcaagaaga 335821 agccggagct ttcctttttt tatggtcacg tttcagccaa ggtgggtgtt tgatgaccta 335881 aatggatcaa ctgcatttgg ccgtaacatg agcaggctga tccgatctcg tttagaggcc 335941 tatgatcagg ctccgattca cccgcaatta ggctggtacg gaggaaaaga taatcgtgaa 336001 tggaagcagt atttcctccg tgatgacgaa aaacaggtat cgaagtgccc gttttcttat 336061 ttaaagaaca tgttcaacaa aatgaaataa atcaaggact ggcagggcga tctttatgac 336121 cctgcttttt ttgatagatc atggtaacga tggcgataat cacgagaaaa cctatgctga 336181 cgaaaaaacc gggccggctt gatttttcaa acaatgtacc ggacacagct gcagcaatca 336241 gaaccatcgc taaataaatt tgcgtttttc ccatgccctc gggatcagtc agctttttgc 336301 tggagaacag gataaacagc caagtgtata aaagcataag ccccgcagct gttgtcatat 336361 gctcataaat gtttttaggc agcactaacg acaaaataat ggagaggaca agccccgcaa 336421 acgtcagccc aagtgccggc cagcatattt ttttgccttc ctttagagta aagcatttcg 336481 gcgcgtcgcc gtcatcagcc attgtacaaa gcaatgtcgt aaccgcaaat agcgaagcga 336541 caagggtcga gaaccctgcg atgatgaaaa tcccgttaaa tatatcaagg atgatctcaa 336601 ggttatatcc ttttaatgac gtaatgaacg gactgtcctg ttcagtaaac gtgtgtaacg 336661 gaaccaaaag cagagcaagc ccgattgaaa tgatataaat aatcgccagc gtcgccagca 336721 tcagtttccc tgatttagac gcttcctcag gtttttttaa gtgaaccgcc atcagcccca 336781 tgacctcaat tccgccaaaa gcgtaaaacg cgtagattaa acctgtccac agccccatgg 336841 cgccgtatgg gaaaaactca ctcgtcttat ttggaacatg tatgccatga tttccgccgg 336901 acaggatacc gcataaagcc aggatggcaa tgacaataaa cataaaaata gcagctgttt 336961 taatgactgc cagcacgttt tctgtttttt caaagacgga caggccggtg aaaataataa 337021 ggagcccaag tactgcgtag attgaggcaa acacccatag cggcacttga ggaaaccaat 337081 gcttcgtaaa gagcgaaatg gctgtcagct ggcttccggt aatcagcatt tctgatgtcc 337141 agtacaccca gccgttgctg aagcctgccc atttgccgaa tgcttttcgg gcatacgcac 337201 aaaacgagcc cttttccggc tgcttcgccg atagcttggc gagctgttca aagacaaaat 337261 acgtaccgat ccctgcgatc agaaatgaaa ggagaacgga aaaaccgctt tttacaattg 337321 cgatgctgga accgagaaag aagcctgttc caatcgtgca gccgactccg atcagtgaca 337381 gctgccacca agccagattc ccttttggct ggtctttttt tgtttggctc attatttatt 337441 caaccccttt tatctaaggt tagattgtga tctgtccaaa gcttatatac atcggatttt 337501 tgcctctttt tacatggaga aggaagcaga cgctcatact aatgaaaaaa ggagcaaacc 337561 aatgacacag caatatattg tggagccgaa aaaagggctt gggctgaagc tgaaaaaggg 337621 gcagatttta aaggtggttg atgtagaagg gcagcaggtg gctgattttg tcgcatacca 337681 tgccaaggat ttttatgaac accttgatca gggagcgacg atagacgcca atcactccat 337741 tcatgtgaag gtcaacgacc atctctactc caacctgtat aagccgatgt taaccctgat 337801 tgaagatacg gtcggcaagc atgatctgct gttgcccgcc tgccgtcctg atatgaacag 337861 gctcttatat gggaagcaaa aggatgagtt tcaggatacg tgctatgaca atatgaaccg 337921 tgcgcttgag cagtttggcg taccgaagcc ccacatgcat tacccatttg cgatttttat 337981 gaatactgtc cttgatgaga aagggaatct gtctgtggaa acgccgcttt cgaatgccgg 338041 agattatgta aggctcaggg cggagatgga tttaattgtc gcgttttctt cctgcccgat 338101 tgaaaaaggg aaatgcaatg gcgacagtgt gacatccata cgggttgaag tcagctgatc 338161 tctcttgttc acagtgaatg aagacctgtg ctatatttaa tagggataca taacagtcat 338221 gattcatttt cattgattta gggaaatgat cagtaataag ggaaaatgta caggaggaat 338281 gattgggatg agcatgcagg aaaagattat gcgtgagtta catgtgaagc cctcaattga 338341 tccaaagcaa gaaattgagg accgagtcaa ttttttaaaa caatatgtaa agaaaaccgg 338401 tgctaaaggc tttgtattgg gaatcagcgg gggccaggat tcaacacttg cgggaagact 338461 cgctcagctt gcggtggaga gcattcgcga ggagggcgga gacgctcaat ttatcgcggt 338521 ccgtcttccg catggcacac agcaggatga agacgatgcc cagcttgctt tgaagtttat 338581 taagccggat aaatcatgga agtttgatat taaatcgaca gtcagcgctt tttctgatca 338641 gtatcagcag gaaacaggcg atcagctgac ggactttaat aaaggaaacg taaaagcaag 338701 aacaagaatg atcgcgcaat acgcgatcgg cggccaggaa ggtcttcttg tgttaggaac 338761 agaccatgct gctgaagcag tgactggttt ctttacgaag tacggtgacg gcggagcaga 338821 cctcctgccg ctgacaggct tgacgaagcg ccagggaaga accttgctga aagagctggg 338881 tgcaccggaa cgcttatact taaaagaacc gactgccgat ctgctcgacg aaaaaccgca 338941 gcagtcggat gaaacagagc ttggcatttc ctacgacgag attgacgatt atctcgaagg 339001 aaaagaagta tcagcgaaag tatcagaagc gctggaaaaa cgctacagca tgactgaaca 339061 taaacgccag gttccggcgt ctatgtttga tgactggtgg aaataagttg aagaaagccc 339121 gctctcggag cgggcttttg tcgtgtacag aagctttatt tgatgcggat atgattcagc 339181 tttaccatta atctgtcggc gaaccttcgg aggctgcctc ttgtatcagg atctaatggg 339241 agttcggctc tcgcggcaat gttctctgcc acatcctgaa tcgacaggtt gtctgtttga 339301 atgtggtcct caaaaatggg tgatgataat ccttcaacac agcggtcaat ttgtttggcg 339361 gcccatgagt tttttccttc tgctctggtg cgcagccttt ttaacaaggt ttcctttgaa 339421 gccattagtg taaagtggtg aacgatcctg ccttcctgtc tgagcctgcc gatgatctca 339481 ttgaagtatt cagggtgtac aatcgtcata ggcacaataa ggatgccgcg gtatgtatct 339541 gtcagagaag ctagcaaact gtaattgaac gcccgccata aaggatagct ttgaaaatcg 339601 tcctttgcga tctcctgcgg caccatggag cgcagcgcaa aacccatttt ctcgggatca 339661 tacacgtaag atgggttcag ccttctgtgc agttcgaagg ctgtttgtgt ttttcccgaa 339721 ccgaatgccc cgtttatcca aatgatcatc gccatttctc ccttcctatt tatcatacag 339781 aaaaagaccc ttccatcgaa gagtcagctg gaaaaacaat aaaggcggaa ggttttaacg 339841 cttttttgcg tcgaagtatt aaaatacctg cagaaatgtt gtacaatgaa tgtcattcag 339901 gcaaaaatgg ctacaacaaa gcgcactata agcttgaccg gtaaagccgg tatctatata 339961 aatattcgct aaataagcat ataatgaata tataatttca ttccttagga ggatttcgcc 340021 gaagatgaac gctaaacgag ccatcccagt aagagaaaga aatatcgtcc tgatcggatt 340081 catgggtgta ggaaaaacaa caatcggcca attggtcgct aaaaaattat atagagattt 340141 tattgatatt gaccagcaga tcgaaaagga tttcaatatg tcaattcctg agatatttga 340201 gaaaaaggga gaagactttt tccggaaaac ggagaaggaa tatattttag acatctgcca 340261 tcataaacga ttcaaaatcg tatctctggg cgggggatct tttaaacaag aagaaatcag 340321 aaattgctgt ctggaaaact gtctcgtgct tcatctggac ctgtcatggg agaactggaa 340381 gcagcgcgcg gatttattga tcgaaagccg ccctgtactg cataaccgtt caatggatga 340441 aatggaacag ctgtttaacg aaagaaaagt catttatgac aagcacaatt caaaagtggc 340501 aacagacaac ctttccccgg aagaggttgc cgattacatt gttgagacat taaaaattgg 340561 ctgggatctt tatcagccga tgtaaaaagc cgtgcgcagc gcacggcttt ttttatcgtt 340621 ttatcccttg tatcaaaatc gcttttaaac aaaaggagat gggctgtccg ttttggttca 340681 atgtaataca gaacgtgtcg cgtgcttcgt ctgatgcgtg attcaagtgg gtaatgattt 340741 gtttttctcg gtcagcgggg gttccgcctc gtttgatcca gctatcgtat tgaatcggca 340801 agttccactt ttggatgtct tgataggcca gttgattggc gctgaacatc gcctgccatt 340861 ctgataatga gctttcacga acatgggaag ggtctcgaag ccggttcaaa tgattgacaa 340921 actcatcaag aacgggatct tcaggcgcgt aatgatcaac taagagaaaa cgtccgtcct 340981 gttttagtac gcgtgcaacc tctctgacag ctttgcggac atctgaaaaa tggtgggctg 341041 cgtatcggca ggtgatgatg tcaaatgaat cgtcggggaa ggggagtgac tctgccgttc 341101 cttgctgaaa gcgtacgttt tcaactcctt tttcttgcgc gaaggaggac gcaacctcaa 341161 ccatctcttt cgttgcatca acaccgatgc actcctgtac ataaggagaa aatgccagcg 341221 ccgtatggcc ggcgcccgct cctatatcca gcactcgatg ctctgcccgg cattccgctg 341281 ttttgatcat caaccccaaa tcttccccct cggcaaatac cttttcatcc cgatacatct 341341 cggcgttttt agaaaacggt gtttcatttg tcatttgaac cagctccttc ttttcgtaaa 341401 tgatgatatg gattatgtta gcaatttctg ttatgattcg tccaagatat aaaaatgatg 341461 aaaatgatag gttcaaccta tggaggctga aatggatatt aaagtgatgg aatatgcagc 341521 ggaaattgcc cggcgccaaa gctttacaaa ggcggcggaa catcttcata tcgcacagcc 341581 gtctctcagc cagcaaatca aaaagcttga ggctgagctg gggcttaccc tttttcacag 341641 atcccatggc tctgttacac tgacacctca cggcaggcgt ttcattgaaa aagccgagga 341701 catcattcgt tccagagatg atttgcttcg ggaaatgcag gagcgatcac agggaatcgg 341761 tcataaatta tccatcggga ttcctgctgt aacagggaga tatctctttc ctccgctgct 341821 gaagcagttt ttggcgcgct atcctcatgt ggaggttcag cttgttgaaa aagatccggt 341881 ttcattagag aagatgacgg caaagggaga agttgacctt tctgttttat ccttgcccat 341941 cgaggatgaa cggctctcca ttacaccctt gctcacggaa ccggttgttc tcgcggtgcc 342001 gaaggaaaaa caaaggtgga tgccgccgga attggtcgcg ctgattgaga aagcgctgga 342061 agaagatgag ggacgccagc cgtgtgtgcc gattgacatg gtaaggaacg tgccctttat 342121 tctgttaaaa gaaggcttcg gctttcgcag gacagttctc gatctctgtg cggaaagcgg 342181 ctttaagccg aatgctgcct ttaagacgag ccatattgaa accgcccaat ctcttgtggc 342241 taacggatta ggtgtgacaa tggcaccgaa tatggtcaga agggataaag atccgggtgt 342301 gatctattta tcgattcaat ccgcgccatc acgaaccctc gtctttgtct ttttaaagaa 342361 ccgctatgtc agtctgacgg cccaggcctt tatggaacta agccgggaaa gtcttaaaca 342421 aacgtttgat gaaggctgtc tgggaaacaa agatgaaaat atttagaaaa caaagacgaa 342481 acgtggtagt ataggaatac aaactaaatc ttataaaaca aaggggaata atcggaaatg 342541 caactattcg atctgccgct cgaccaattg caaacatata agcctgaaaa aacagcaccg 342601 aaagattttt ctgagttttg gaaattgtct ttggaggaac ttgcaaaagt ccaagcagaa 342661 cctgatttac agccggttga ctatcctgct gacggagtaa aagtgtaccg tctcacatat 342721 aaaagcttcg gaaacgcccg cattaccgga tggtacgcgg tgcctgacaa ggaaggcccg 342781 catccggcga tcgtgaaata tcatggctac aatgcaagct atgatggtga gattcatgaa 342841 atggtaaact gggcactcca tggctacgcc acattcggca tgcttgtccg cggccagcag 342901 agcagcgagg atacgagtat ttcaccgcac ggtcacgctt tgggctggat gacgaaagga 342961 attcttgata aagatacata ctattaccgc ggtgtttatt tggacgccgt ccgcgcgctt 343021 gaggtcatca gcagcttcga cgaggttgac gaaacaagga tcggtgtgac aggaggaagc 343081 caaggcggag gtttaaccat tgccgcagca gcgctgtcag acattccaaa agccgcggtt 343141 gccgattatc cttatttaag caacttcgaa cgggccattg atgtggcgct tgaacagccg 343201 taccttgaaa tcaattcctt cttcagaaga aatggcagcc cggaaacaga agtgcaggcg 343261 atgaagacac tttcatattt cgatattatg aatctcgctg accgagtgaa ggtgcctgtc 343321 ctgatgtcaa tcggcctgat tgacaaggtc acgccgccgt ccaccgtgtt tgccgcctac 343381 aatcatttgg aaacaaagaa agagctgaag gtgtaccgct acttcggaca tgagtatatc 343441 cctgcttttc aaactgaaaa acttgctttc tttaagcagc atcttaaagg ctgataaatg 343501 tgaaaagccg ccgcatatca tcaggcggtt tttttctgca aactgccgga atgagaacag 343561 actggagacg aatagatatg aaacaaagaa tcattgatga attaaaacgg atcgagcagt 343621 catacggagt caaaatcgtg tatgccgtcg agtcaggaag ccgcgcatgg ggatttccct 343681 cgcaggatag tgattacgac gtccgcttta tttatgttcc gaaaaaggag tggtactttt 343741 caattgagca ggagcgtgat gtcattgagg aaccgattca cgatttgctg gatatcagcg 343801 gctgggagct gagaaaaacg cttcggcttt tcaaaaagtc aaaccctccg ctactcgaat 343861 ggctgtcctc agacattgtg tattatgaag catttacgac cgcagagcag ttaagaaaac 343921 tccgcacgga ggcatttaag cctgaagcaa gcgtgtatca ctatatcaat atggcgagaa 343981 ggaacgtcaa ggattatcta caaggacaag aggtcaaaat taaaaagtac ttctacgttc 344041 ttcggcctat tttggcctgc caatggattg aaaagcacgg aaccataccg ccaatggact 344101 ttactgtttt gatgaatgaa cttgttgctg aacccgagct gaaggctgaa atggaaacct 344161 tgcttgaacg gaaaagaaga ggggaagagc ttgacctcga agcaagaatc gatgttattc 344221 accaattcat tgaaacggaa atcgaaagaa tcatggaagc ggcaaaagaa ctgaaggcag 344281 agaaaaaaga tatgacatct gaattgaacc gtttgctttt gaatacggtt gaagaagtgt 344341 ggaaggatgg aggaagctga tgttttttgt cgcttccttt tctcctttat tcgacagaat 344401 ccccccccga ctttctaact atctgattgt ggcaaaccca caaaaataat cagaatcttt 344461 gtattttgag aatattgtga acgctggttt tgtccattta caataaactc atacaaatac 344521 ttcttagatt gcggggtgtt gaggttggaa gtgatcacaa gagatttttt cttattttta 344581 tccaaaagcg gctttctcaa taaaatggcg aggaactggg gaagtcgggt agcagcgggt 344641 aaaattatcg gcgggaatga ctttaacagt tcaatcccga ccattcgaca gcttaacagc 344701 caaggcttgt cagttactgt cgatcattta ggcgagtttg tgaacagcgc cgaggtcgca 344761 cgggagcgta cggaagagtg cattcaaacc attgcgacca tcgcggatca ggagctgaac 344821 tcacacgttt ctttaaaaat gacgtcttta ggtttggata tagatatgga tttggtgtat 344881 gaaaatatga caaaaatcct tcagacggcc gagaaacata aaatcatggt caccattgac 344941 atggaggacg aagtcagatg ccagaaaacg cttgatattt tcaaagattt cagaaagaaa 345001 tacgagcatg tgagcacagt gctgcaagcc tatctgtacc ggacggaaaa agacattgac 345061 gatttggatt ctttaaaccc gttccttcgc cttgtaaaag gagcttataa agaatcagaa 345121 aaagtagctt tcccggagaa aagcgatgtc gatgaaaatt acaaaaaaat catccgaaag 345181 cagctcttaa acggtcacta tacagcgatt gccacacatg acgacaaaat gatcgacttt 345241 acaaagcagc ttgccaagga acatggcatt gccaatgaca agtttgaatt tcagatgctg 345301 tacggcatgc ggtcgcaaac ccagctcagc ctcgtaaaag aaggttataa catgagagtc 345361 tacctgccat acggcgagga ttggtacggc tactttatga gacgccttgc agaacgtccg 345421 tcaaacattg catttgcttt caaaggaatg acaaagaagt aaaaaaggag agattatcat 345481 gacaacacct tacaaacacg agccattcac aaatttccaa gatcaaaaca acgtggaagc 345541 gtttaaaaaa gcgcttgcga cagtaagcga atatttagga aaagactatc cgcttgtcat 345601 taacggcgag agagtggaaa cggaagcgaa aatcgtttca atcaacccag ctgataaaga 345661 agaagtcgtc ggccgagtgt caaaagcgtc tcaagagcac gctgagcaag cgattcaagc 345721 ggctgcaaaa gcatttgaag agtggagata cacgtctcct gaagagagag cggctgtcct 345781 gttccgcgct gctgccaaag tccgcagaag aaaacatgaa ttctcagctt tgcttgtgaa 345841 agaagcagga aagccttgga acgaggcgga tgccgatacg gctgaagcga ttgacttcat 345901 ggagtattat gcacgccaaa tgatcgaact ggcaaaaggc aaaccggtca acagccgtga 345961 aggcgagaaa aaccaatatg tatacacgcc gactggagtg acagtcgtta tcccgccttg 346021 gaacttcttg tttgcgatca tggcaggcac aacagtggcg ccgatcgtta ctggaaacac 346081 agtggttctg aaacctgcga gtgctacacc tgttattgca gcaaaatttg ttgaggtgct 346141 tgaagagtcc ggattgccaa aaggcgtagt caactttgtt ccgggaagcg gagcggaagt 346201 aggcgactat cttgttgacc atccgaaaac aagccttatc acatttacgg gatcaagaga 346261 agttggtacg agaattttcg aacgcgcggc gaaggttcag ccgggccagc agcatttaaa 346321 gcgtgtcatc gctgaaatgg gcggtaaaga tacggttgtt gttgatgagg atgcggacat 346381 tgaattagcg gctcaatcga tctttacttc agcattcggc tttgcgggac aaaaatgctc 346441 tgcaggttca cgtgcagtag ttcatgaaaa agtgtatgat caagtattag agcgtgtcat 346501 tgaaattacg gaatcaaaag taacagctaa acctgacagt gcagatgttt atatgggacc 346561 tgtcattgac caaggttctt atgataaaat tatgagctat attgagatcg gaaaacagga 346621 agggcgttta gtaagcggcg gtactggtga tgattcgaaa ggatacttca tcaaaccgac 346681 gatcttcgct gaccttgatc cgaaagcaag actcatgcag gaagaaattt tcggacctgt 346741 cgttgcattt tgtaaagtgt cagactttga tgaagcttta gaagtggcaa acaatactga 346801 atatggtttg acaggcgcgg ttatcacaaa caaccgcaag cacatcgagc gtgcgaaaca 346861 ggaattccat gtcggaaacc tatacttcaa ccgcaactgt acaggtgcta tcgtcggcta 346921 ccatccgttt ggcggcttca aaatgtcggg aacggattca aaagcaggcg ggccggatta 346981 cttggctctg catatgcaag caaaaacaat cagtgaaatg ttctaagcgg gactaaatgg 347041 gcatcctccc tgcgggggtg tccatttcat ccatatacta taaaaaagag gaggaagtgc 347101 catagaaaac acacagctga ttatttcgat ttgtatttat atggcgggaa tgctgctaat 347161 cggctacttt gcttacaagc gtacgtcgaa tctgacggat tatatgctgg gaggacgctc 347221 tttgggtccg gcagtaaccg ctctcagtgc cggcgctgcc gatatgagcg gctggctgct 347281 aatggggctt ccgggcgcca tgttttctac tggtctgagc ggcgcttgga tcgtcatcgg 347341 actttgcctt ggagcgtggg cgaactggct ttacgtcgca ccacggctga gaacctatac 347401 tgaaaaagcg gggaattcta ttacaattcc cggattcctg gaaaatcgct tcggagatca 347461 aacaaagctt ctcagactgt tttcgggaat tgtcatttta gtctttttca cgttttatgt 347521 atcgtccgga atggtgtccg gcggcgtctt attcaacagc atcttgggga tggattatca 347581 caccggcctg tggattgtga cgggtgttgt tgtggcatat accctgtttg gcggcttttt 347641 ggcagtcagc tggacagatt ttgttcaggg gattattatg tttgccgcac tcattcttgt 347701 gccgatcgtt acgtttttcc acacgggagg agcaggtgat acagttgctg aaatccgctc 347761 tgtagatcct gatatgttta atattttcaa aggaacgagc gtccttggca ttatttcttt 347821 gtttgcctgg gggctgggat actttggcca gccgcatatt attgtgcgtt ttatggcgat 347881 aacgtctgtc aaagagatca aaagagcgcg cagaattggg atgggctgga tgattttgtc 347941 tgcagtaggc gcagtgctga ccggtttggg cggaatcgct tattaccatc agcgcggcat 348001 gacactgaag gacccagaga cgatttttat tcaattaggg aatatcttgt tccatccgat 348061 tatcacgggt tttctgattt cagcgatttt ggccgcgatt atgagtacaa tttcttccca 348121 gctgcttgtg acatcaagct ctctggtaga agatttgtat aagtcgatgt tcagacgctc 348181 agcttcagat aaagaactgg tgtttttagg ccgactggct gttctggctg tttcaattgt 348241 cgcgttggtt ctggcttggg agaaaaataa caccatcctt ggattggtca gctacgcgtg 348301 ggcgggcttc ggtgcatcat tcgggccagt tgtactgctc agtctgtttt ggaaacgaat 348361 gaccaaatgg ggggcactcg ccggcatgat tgtgggagca gcgactgtaa tcatttgggc 348421 gaatgccggt ctttcggact ttctgtatga aatgatacct ggttttgctg cgagtctatt 348481 atctgtcttt tttgtcagca tattgacgca ggctccgtca caagctgtca cagaccagtt 348541 caacgactac caagatacaa tgtcgcaata aagatcgaaa ggaggaggaa ggggctgtcc 348601 ctttttcctc ttttctcctt ttaagcggcc atttttttct tttggaaaca aacgtatttt 348661 tttctataca aaaagacccc gtatggatat gattaaagta aaaaaagtat aggagaaaaa 348721 ggtatggaag agcttttaga gagagttttt tcattttcag atgttgataa gctaattgat 348781 tttattagct atgaactgca aaagccagtg atactggaaa gcgcggattt ctttttgtta 348841 gcctataatt cttactatat taaccatttt gattctgcca accagcagac tattttttcg 348901 aaaaagtgtc cggtccagat ttttgagagg tttctgaagg acggaattat tgaaaaattg 348961 aaaacagagc ctgagccttt tcgcgtcaat aaaattgaaa gcattgggtt aaaccagagg 349021 gtggtcgtga gtgcaaagca caaaggggaa gtcatgggct acatctggat tcaggagctg 349081 gaccaaaatc tgacggatga agagctcgac tttttgtacg agacctcctt ccatgtcggg 349141 aaaatcattt ataaaacgaa taaattgaaa caggaaaagg aagaaaaagc agaggatctc 349201 atcaaacggg cgatctatca gcaatttacc tctgagaagg aactcagacg ggaagctgaa 349261 aggatcaaca ccgtgctgcc ttccatgttt tcagttgtta tcctgcacgc cgcaaatggg 349321 gatggggaag cggttgagga tttaaaggaa aatatcaggt cgtacctgaa tttacgggat 349381 aaggtcagtc atgtcttaac gatcgaatca aacattgtca tcgtcgtagc gagtttttcc 349441 caaaaaagct ccgtctcctc agcagcttct gagtttatta acaagctgtt aacacatttt 349501 cactttcaaa aaatacctac ccctatttat atcggtatcg gaaacgaata taatcaccta 349561 ttaaaacttg gcaagagcta cacagaagca cttgaagtca tcaaagccgc agaaatcacc 349621 ggcaatcagg aaaacattcc atatgaatat gccaaactcg gcatttaccg ctatttagaa 349681 agcatcgaac agaaaaatga atttttagaa tacgagaata aagatttagc tttattaaaa 349741 gcaaaagacg aagaaagcag cactgagctg ctcaaaacct tggaaatcta tctcctcaac 349801 aactgcaaaa caaaaccagc ggcagaacag ctgtttattc accaaaatac attgaattac 349861 cgcatcaaac agattactga gatgacgtcg atcgatttaa gcgatttcag aacgcggtgc 349921 cagctctatc tcgatttgat gctgatgaaa aagaaataaa aaagaaacca gtacttgtac 349981 tggtttcgtc ttcacttaaa atcctctgta aacatacgga tcatcaggtt ttttaatggt 350041 attccagtca gttactttga cgacagggag agttgacttg aatggctggt aatattctga 350101 ggccagagtg cccttaatgt gaatccattc atcatccttg atgtccatgt ccttcggaaa 350161 ttccacaagc atcccgtaca cgccggaatc agcgatacag tgaatgatgc caaaccttaa 350221 tacgaacagc tgatttttgt taattgcgtt tcctttgtaa gcaaatccat gaaattctat 350281 cgtccgtccg agaaattcac ccggatagtt atagatggtt tccattcctt ttaggaaatc 350341 gtcatcggtc agagaaatct cttttttgct ggaatactta ttaaacagct gtttcatttg 350401 tttgtcatag ctgtcttgcg cgtaataaag gctggcatca ggccgcaaat actgtgtttg 350461 ggagtagtga tctccgctct ccatcgcctt aaacgagaac ccttttgttt tgactatgga 350521 tgagtcaagc gttgcaatcg ggaagaagat gcctgacacc aaaggaaaaa gaaaaacaac 350581 ataaatcaaa taacgctgat aaaatggctt gttttgttca tggtcatgct cgtgatcatg 350641 gccgcacccg caatcatggt catggtgatg tccgcttttt tcaggcgact tgataaatag 350701 atatgcttgg acggcggtca gaatggccag caggaagatc gcaataaagg aaagataggc 350761 atatttcata ttgatatatt ttgttagatt tcctgaggca tgcagatgat aaaagaaaaa 350821 cgtaaatccc atcagcacca ataaacgaaa catccaatca cccctttacc agtagtgatc 350881 ccgctaaaac aatcacgaca atgtatgtaa tcagcaggaa aacaaatcgt tttttgaagg 350941 ccgcaagcat catcaataga ttcttaatat ccaccattgc accaaagacg agaaaggcga 351001 ttaacgatcc taatgaaaac gtgctgctga aggaagacgc gatgaacgca tcaacttctg 351061 aacaaagcga caggacaaac gccagaccca tcatcacgag ggaagaggat acatcattct 351121 gcccgatcgc aagcagagtg gatgttttga catacgtctg catagcggct gcgataaagg 351181 cgccgatgat taaatatttc cccacggaga aaaattcatc aatggcatgc cgcaaggtcc 351241 cgcccagttt ttggagcaag gtgccgtgat gatgatggtg gtgcccgggt tcatcaggct 351301 ttaaaagctg gttatcctta aattgatagg ataagatgac cccgatgatc agcgaaacgg 351361 cgagagccag tccgcctctg taaaagacca cgctccatct attcccgaac gcaatataag 351421 tagaaaataa aacgatagga ttaatgatag gcgcggtcag catgaaagca acgcccgcat 351481 gcagaggaac tccctttaac agaagccgcc tcgtaatcgg gatgatgccg cattcgcagg 351541 cgggaaataa aacgccggcc agcgcaccga ataaaacggc gagaaaacgg tttttcggca 351601 tgattcttgc aatcatttct tcagaaacaa acatttgaat gattccggaa agtatgacgc 351661 caatcagaat aaacggaatg gcttctatta aaatgctgat aaaaatagaa ttcagctgaa 351721 gaaaagatga ttgtgctgtc acaataaaac ctccgctcat gttaagctgc ctttcttatg 351781 ataccagaaa aaaaggcact gcttgtttga cggaggaggg gaaaggatcg tttcactttg 351841 gttaggattc caaaaagccg agtaggatac tgcctgtttc tgcagcttct tttccgagcc 351901 aaatcaggtg tccccatgag tgaagcaaac agagaacagc gccacgaatg tgctcttttg 351961 catgatgtgc atgtgacaag tcaaccaatc cgtcataaac actttgcata atcagcacgg 352021 gacatatgat ggcttgcagg tcttttaaag agacagcggc ggtttgtgac aagtcaatca 352081 gaaatccttc acccgagcgc tgccggctgt tcattttccg aaatgcttct atgtcttttt 352141 cattcatcaa ggacttgatt cgctgaaacg gaagcgtgct gaattggggg ctcatagctc 352201 gaaacatcaa acgcgggaaa gcgttattca aggaagaaat cagcttccat atccactttt 352261 ccaccggcgg gcggaagaga atttccccca atttatattc agtgtctttt ggggtgagcc 352321 actctttggt gactgcggat tgcagggtca atgtatttac tctttccgga taatgtgagg 352381 caaagcatat gccgctcggc cctcctgctg agatggcgat cacatggaca ctctcgattt 352441 gtagatgatc taataatttc acatagaaac ggcaggcatt ggcaagactt tttccaattt 352501 cttttgacgt ccgtccatag ccaggccttg aaggcgtaat gatggaatac ccttgttcaa 352561 tcaacgctgt gtatccgaat tcctcgtaac aatttgaatg cccgccatgc atgacaagga 352621 tcggagttcc cttgcctgtc acagaatatt ctagtgtacc gccatcgaag gtgatcgttt 352681 caactcgtct tttcatctgt ttcacccaat tggtttttgc ctattataga gttttcagca 352741 attgaccaca aggtagaaga aatgaataaa caaaggccct tgaaatatga tatactttgt 352801 attgatattc attctcaatt aaaactttga tatagatgtg aacgggaggc aggacggatg 352861 gctgagaatc aagaggtata tgacgttacg attataggcg gggggccgat cgggctgttt 352921 actgcttttt actgcgggat gcgggagctg aaaacaaagg taatcgaatt tttgccgaag 352981 ctcggaggga aggtgtcttt attctttcct gagaaaatca ttcgcgatat cggcggcata 353041 ccggggattg cgggaaagca gctgatcgag cagctgaagg agcaggcggc aacgtttgat 353101 cctgatatcg tattgaatca gcgtgtgacc gggtttgaac gcctagatga cggcaccatt 353161 gttctgacgg gttctgaagg gaaaaagcac tatacaagaa ctgtgatttt ggcttgcggc 353221 atgggtacac ttgaggtcaa tgagtttgac agcgaggatg cggcccgata tgcgggcaaa 353281 aatcttcatt atggagtgga gaagctcgat gcgtttaaag ggaaacgcgt ggtgatatca 353341 ggcggcggag atactgcggt cgattgggct aatgagcttg aaccgattgc ggcgtctgtg 353401 actgtcgttc atcggcgtga ggaattcggc ggaatggaaa gcagcgtgac gaaaatgaag 353461 caatcatcgg tgcgggtgct tacgccttat cggctggagc agttgaacgg agatgaagag 353521 ggcatcaaaa gcgtgaccgt ttgtcatact gagtctggcc agaggaaaga catagaaatt 353581 gatgagctga tcattaatca tgggttcaaa attgatctcg ggccgatgat ggagtggggg 353641 ctggagattg aagaaggaag ggtgaaagct gacagacata tgcgaacgaa tcttccgggc 353701 gtgtttgtgg cgggcgacgc ggctttttat gaaagcaagc tgagattgat tgccggcgga 353761 tttacggaag gcccgacagc ggtcaacagt gccaaggctt atctggaccc taaggccgag 353821 aatatggcga tgtattccac ccatcataaa aaattggtgc ataaataaaa cagcccttga 353881 ggaaaagggc tgcttgccat caggtgtgaa ggagtttttt ctctgcatgt tgattgtgga 353941 tgaaagctag caattcatcc tgttcttgta cggctgtgaa tccataaatg ccggcagctg 354001 agtcatcgcc tatgcagacg ataggagggc ggcttgctga cggttccggc aaaatgccaa 354061 tttgttcgcc accattgatc aattgctgaa cggacagctt gtttgggcaa atgaccatgt 354121 gcagcgggga ttcactgatg gtacgctgaa tcatgtgggt gaaccggtca tctatgacgt 354181 tttcatgagt gatataaaac gaacaggatt catgcttttg catgttttcc actgcatggc 354241 ggctcccgac aacaagacgt ttctctgaat caggctgaat ggcggtgaca agaaagcccc 354301 gtttctcaag ctctgtcttt gcttgctcag atgctgcact cagtttggct gtcagctggc 354361 ggatgtcgat tttctgagaa gccagtgctc tgaaaaattc acaaaccgcc cggcgcgatg 354421 tgaaaaaaac gtcttcaaag gtgccaatct ttcgaagaat ttcttcattg acaggcatgt 354481 tttcggtccg ccatttcggc cactcgatga gatcggcgcc ggaatcgcgc agcttgtctg 354541 caagcgggtc ttcatcttcg ccatgagtca caaccatcaa atgccgtccg atgagcggtt 354601 tgctttcaaa ccagctgtgt gtttgaaagt tgacgatgtc tccgatgacg ataatcgcag 354661 ggtttgtaat ctggtgttcc tgcacttttt gctgaatgtt ctcaagtgtt cctttcacac 354721 tccgctggcg gccccacgtt ccccattgga tgacaatgac agggacagaa ggcgatttcc 354781 cgtatgaaat aagctgctgg caaatataag acaagttctt gacacccatg taaaaaacaa 354841 gggtttgaac gcttcgggcc agcccttccc agtcaaggtt cggcgtgcct tttaatgatt 354901 tatcatgcgc tgtaatcatg gcaaaagacg atgcaaaatc ccgatgcgtg acggggatgc 354961 ccgcatatag cggcgctgca attccagagg tgattcccgg caccatttca tagcgaatgc 355021 cgtgctcatg aagagcatct gcttcctcgc cgactctgcc gaatacgctc ggatctccgc 355081 ccttcaagcg aacgacggtt aacccattta atgctttttc aaccagcagg gcgttaattt 355141 ctttttgttt cataaaatgg cggtttggca gttttccgca ataaataaac tggcagtccg 355201 gtgatgcaaa ttcgagcagc ttcgggttgg cgagccggtc atataaaatc acatctgctt 355261 ccttgagcgc ctgttttcct ttgatggtga gcaggcctgg gtcgccgggt ccggctccca 355321 cgaaatatac gattccgttc ttcatgatca tgtcatcctt ccgtcactgt aaaaaatgaa 355381 ggaccactag aaaagtgatc cggtcttttg atcaatatac gagataaaca tgttctcctt 355441 cgatcagcgt ttcatatgtt ttgacgcatc cgtggtcagg ttcttggacg attccgtctt 355501 ctaaggaaat tttccagtcg tgcatcgggc agaaaacata ttgaccgctg acgatgcctt 355561 ctgccaggac gccgccctta tgcggacagc ggttttcaat ggcgcggatg cttccgtctg 355621 aaagcttgaa aaccgcgagc tccttatctt caatatacac tgttttgcct aattgttcag 355681 gcaattcttc aatttttccg atacatactt ttgttacgtc tttgtttacc atgtccattc 355741 ctcctcaatg atagtttttg tcattatgat gtggtcacga cattttcaaa taattcttta 355801 gaggtttgtt tatcctctaa aaagtctttc cacggatcct tgtggacaga gagtgtttca 355861 ttcattcggc cgttcagctc ctgccgcttt tccggatcgt ttaacacgga ttggacatgg 355921 gataaaccga cgcgctcaag ccatgcggac gtacgctcca gatagtttgc ggtttccctg 355981 taatattgca ggtaagcgcc cgcgtattct aagacttctt catttgtttt caccttcatc 356041 agcaaatcgc cggcacgcaa atgggttccg ccgtttccgc cgacataaag ctcccagcct 356101 ccgtcgatgc cgacaacgcc aaggtcctta atgccggatt ccgcacagtt tcgcgggcag 356161 gcagacacgg ccattttgac tttgtgaggc gtgttcagcc cttcgaattt tttctcaagc 356221 gcaatgccca gtgccatgga gtcttgtgtg ccgaagcggc agaattgctc gcctacacat 356281 gttttcactg tgcggagcgt ttttccgtac gcgtagcccg atggcatatc aagatcttcc 356341 cataccttcg gaaggtcttc ttttttcacg ccgataagat caattcgctg gccgcctgtc 356401 attttcacga gcgggatctc atatttgtca acgacatcgg cgatcttgcg caaatctgtg 356461 gagttggtca cgccgccgta catccgagga acgactgagt atgttccgtc tttttgaata 356521 ttggcgtgca ttcgttcatt aacaaagcgg gatgtccggt catcctcgta tttggttgga 356581 ttgatcatgc ctaagtagta gttcagagcg ggtcggcatt tagaacagcc ttctggcgtt 356641 ttccagccga gcacattcat gacttctctt gtatgtgaca gccctttggc tttgatttct 356701 tctacgactt catctctcga caatgtggtg cagccgcaaa tggcttcttt ttgcgctgac 356761 gcatcaaagt ctgatccgag cgtatgctgg aggatttctt ctacgagcgg cttacagcct 356821 ccgcatgagc gggatgcgcc ggtgcatgct ttgatttcgt ccgttgacga gcagcccttt 356881 tcctgtatgg cttgaataat cgcacctttt gacacgccgt tacagccgca gatgatttca 356941 tcgtcgctca tcgctgcggt tatgcttgtg cctgcttcct ggctgagggg ctgtaagatt 357001 gatattttag aggtttcaga gatatcggct tctttttgaa tcatagaaaa caggcgattg 357061 ccttcgctgc tgtcgccgaa taaaacagca ccgacaattt gattgcctct caggacaatt 357121 tttttataga tgccgtcctg ctcatcgaag actttaatcg cttttttctc ctctgattcg 357181 ttaaagtcac cggcagagaa gacctcgacg cctgatacct ttaactgtgt ggagagaacg 357241 gagccctcat acggttttgt ttcgatgccg cacatatgct ttgccagcac ttttgcctgt 357301 tcatacagcg gcgccacaag cccgtaggcg attcctcggt gctcggcaca ttcgccgacc 357361 gcgtaaatgt gcgggatttc agtctgcata taatcgttga cgatgatgcc gcggttaacc 357421 ggaatgccgc tctcggcccc gagcgttgta tttgggcgga tgccgacagc catgacgact 357481 aaatcagctt caatgcttgt gccatccttg aatcggaggc cttcgacacg gtcgtcaccg 357541 acaatttctt ctgtttgctt ttcaagtaaa aaggtcatac cttgtttttc taactcgttt 357601 tgcagcaggc gtcctgccgt tgcatcaagc tggcgctcca tcaggaatgg ggcaaggtgg 357661 atgacggaca cgtccatgcc gagattcagc agtccgcgag ctgcttccaa accaagtagt 357721 cctccgccga tgacggcagc ttttttatat tgttttgacg cggcgagcat tgtgtctgta 357781 tcttttatgt cccggaaagc tgtgacgcct tttttgtctg cgcccggaat cggaaggata 357841 aaagggaccg atcctgtcgc caggatcaat tcatcgtaag gctggattct gtctgcatct 357901 gtgatgactg ttttgttttc cgtgtccact ttgatgactg tttcatttgt atacaattga 357961 atgttgtttt cttcgtacca gtcccaatcg tttaacgtaa tatctttaat atctgtatcg 358021 ccttgaagca cttttgacaa aaggattcgg ttgtaattgg gatgcggttc ggcaccgaaa 358081 attgtgatct gaaactcgtc tttagcaaca ctcagtatct cttcaatggc ccttaccccg 358141 gccattccat taccaacaag aactagctgt ttttttccca tcagatgatc cgctccttat 358201 caaatgtttt ttccagcgta gcacagcaaa aaggaatatt taagatacat gttataaaat 358261 gtaacaaaat atacgaaaag ttctaaaaat tttatgaaaa atttaaatag gtatgattcg 358321 gacggcgcat accttaaaac cgggcatttt acaggctgga tctaaggctt ccccgattaa 358381 atcattcaca ttttgagcgt ctgcccaatg gatgggaaca aaaacggtat cttttctgat 358441 ttgttctgat aatttgctgc ggacggtgat gcttccccgc ggcgattcta tttttaccag 358501 tacacggtcc tcgatattgt aggtcgctgc tgtttgcgga tggatctcca taaacgattc 358561 aaaatgtctc gcggcaaggg cggcgctttt tcttgtttgg acgcctgtta agtagtgaga 358621 catgactctg cctgtcgtta aataaagcgg ataatcggct gtcggcttct cttttggaac 358681 aggtggttcg tttggaatca cacttaatgc cgctttttga tccggatgag caaatgattc 358741 tgtaaacaag cgcccagttc cgggatgatc agattccgga cacggccaat gaatgccgcc 358801 ttcacgtctg agcctgccgt atgagatgcc tgaataatcg gcaatcccgc ctcggctcgc 358861 ttctctcaat tcattgaaaa tatcctccgc tgacgtataa gaaaagtagc ggcccttgcc 358921 gagagcggat gcgagatcac aaatgatctg ccaatcatgc tttgcttcgc cggggcatgg 358981 ccggcttgct tctcttaatg tcacgcgtcc ttctacattt gtcatggtgc cttcatcttc 359041 taagtaagag gaggcaggta aaatcacatc tgcgtatttc gcagtctcag aaataaacaa 359101 atcgattgcg acaaagaatg tcagtcttct taaagccttt ttcacgagat ttgcatttgg 359161 actggaaaca gcagggttgg agcacatgag gaacagtcct ttgatgtcgc cgtcattgat 359221 tttttccatc atttcatagg ctgagacacc ttttcgcggg agttcatcct gatggattcc 359281 ccacactttc gcaatatgcg cccggtgttc ttcgttttcg atagaacggt agcctggaag 359341 ctgatcggct ttttggccat gctctctggc gccttgcccg ttgccttgtc cggtgatcgc 359401 cccgtagccc gagtaaggtt tgccgatttt tcctgtgatc agcaccatgt ttaagaagcc 359461 tttcacagcc gctgttccat cggtttgctg ttcaatcccg cgggctgtaa acagcatgcc 359521 ggacgtttcc ttggcaaact tcacagcagc ttttcttata tccaccagcg agacactcgt 359581 ctgttcggcg atgtcattca ggtccaacga gtcagtatgc tgcttcagct cttcgaatcc 359641 atttgttcgt gattgaatga aatcctcgtt tataagctgt tcgtcaatga tgattttgac 359701 gagaccgttg gcaagggcgg cgtctgtgcc gggtttgatt ttcagatgaa gatcggcgat 359761 tttcgttgtc gctgtttcac gaggatcaat ggcaatgaag taagctccgt tttctttcgc 359821 tttttcaaaa tacggcataa tcgtaggctg gcattccgca atattggtgc cggccagaat 359881 gatcacacgg gtgtggggga tgtctgataa aggattcgtt aagcctctgt ccgcgccgaa 359941 tgtttggttg gctgcggtgg ctgctgcgga catacaaagt ctcccgttgt agtcgatgta 360001 ttttgtctgt aagcctactc gtgcgaactt ccctaacaaa tacgcctctt catttgtaat 360061 cgaggcgctt ccgtataccg ccatggcgtc atgtccgtgt tcagtttgga tcattgtcac 360121 ttggtctttg atatgattca gtgcttcttc ccaggaaaca ggcataaact cgccgttttt 360181 cttcagcagc ggccgggtga tgcgggagga gttcaaggca tgctggtgag cattcatgcc 360241 cttgatgcat agccgaccct gtgtcgtagg attatcaatc ccgatcgcag tgtacttttt 360301 gcgcgtgacg atggtttgtt ccacgagctg cattttgcac tgcatgctgc aaaacgggca 360361 ttgagtgtca tatgtttttt ctgattggac gtcttgctgt ttatcacgga aatatctaag 360421 cagtcgttca gtcaaaatgc ctcatccttt cttatatgcg cccgtctcta cagtcgggtt 360481 ttgaatcagt gacagatctg tttggaggct ttccagcagc tgtgccctta ggtcttcttc 360541 gaatagcact tctctgatat gaacgatccc gagacggtct atccactgat gaacaccttc 360601 taagtaatga gccgtttccc gataatactg gatcagtcct ttgatcatgc cggcagtgct 360661 gtcttcgttc tcagtcacgc aaaacaaagc tcctgaacgg gcatgagttc cccggacgcc 360721 gccgatgtga atgtcccagc cagcttgtgt ccgaattgcg ccgacatctt gcagggcggc 360781 ctcggtgcag tctgtttcac atgataagct gatagaaatg ggagcgggta agggaagcat 360841 ctcaagttgt ctttcgattt gggctgccag ctgctgaatc gatcgatttt gcccgcatgt 360901 acatgctttg atgctttgca gcgcgtgtcg gtgttcatta gtgtaaacgg gcattttcag 360961 gtcttttttc atgttcggga gatccgcagg cttgatcccg gaaagcttca gcctttggcc 361021 gtgagtgatg gatacgtcgg gaatgctgta tgcctcaatg atgttggcga tggttcttag 361081 ctgctccgcg tttgtccgcc cgccgtacat ttgcggaatc aggatgcatg tctcttcagt 361141 ggctggctca ggctggacaa acccagggta cagcatttcc agatagtatt gaatcgcagg 361201 aacacaagta ctgcatccgt tttttgtttt ccagtcaagc tggttcatca cttctgccgg 361261 attagtgaat ggcctgcgct gaagctcagc gatgatgtcg tcttctgtaa aatcagtaca 361321 gctgcaaaac gaaggtgtgc tggcgggctt cgtatattcg ctgttggtca tgtatctcaa 361381 aaggtcttca acgagcggtt tgcatcctcc gcaggaccca gtggctttgg tgcagtgctt 361441 gacttcctca acagttgtta agctattcgt gtgcaccgcg tcttcaatcg cgcctttcgt 361501 cactgtgttg cattggcaaa tcgtttcact ggaaggcatg gattcaaata aagggccgct 361561 tgtctccggt tcgatgatct gttttttggc aatggagatg tctcgttgtt taagcaggct 361621 gtcgagaagc cgctgcttgt cacgggtgtc tccgaataaa ataacgccgg ccagtttgtc 361681 atctacaaaa agcgcttttt tataaacgcc tgcttgttcg tcgtagattt tgatgctcgt 361741 cgtgcgttca tcctcttgga tctttcctgc tgaccacaca tcgattccag ctatttttaa 361801 cgccgcagat ggtgctgagc cttgatattc ctcacatgga acgccgcaaa tatgactggc 361861 gagcgctttt ccctgctcat aaagcggagc caccaatccg tacaccgttc cgttatgctc 361921 agcgcattca ccaacggcgt agatattcgg ttcgcttgtc tgcatgaagt cattcacgat 361981 gatcccgcgg ttcactttga ttccagcgga tacagccaat tcaatattcg gtttgacgcc 362041 ggccgccatc acaatcaagt ctgcttttaa tgaagagcca tctttaaaat ggattcggtc 362101 tgccttcgtg gcgccggaaa tggagacggt gtctttctcc aaaagaaagg ttaggccttt 362161 ttgttccagc tctgtttgca gcagccgcgc cgctgtttga tcgagctgtt tttgcataat 362221 gccggcggag tggtgaatga cgctgacatc cataccgaga tgctgtaaac ctactgcagc 362281 ttccagtcct aataagccgg ctccgattac cgcagccttt tgaaagtgct gggccatgtt 362341 catcagcgct tggcagtctt ctattgtccg aaatccatag acaccttttt tgtctgcccc 362401 ggggataggg agaatatgag gggaggagcc tgttgccact attaatttgt catacgacag 362461 agtgcgtttc cgatctgtga tgacctgctg ctgatctgta tcaatctgaa taaccgtttc 362521 gcctgtgtaa agcgtgatcc cgtgcttgtc gtaccaatcc ttgctgttca gtgtaatatc 362581 atcgagtgac gcttcaccct gcaatacaga ggataagaga atgcgattgt aattgggatg 362641 cggctcgctt ccgaaaatga caatctcaaa catgtggcga ttcagcttta atacttcttc 362701 aatacagcgg attccggcca tgccgtttcc cgctaacact aatctttgtt tcttcatgta 362761 tcagacctcc tttggcgaag ctcgtaagtt ttctcctatt aaaaattatg tcacaatgca 362821 ttgttaacgc attaaacgtg tcacaaaaac ttacacatgt cttttccaga aaataatggt 362881 cctatatcct tgattcagaa aatgtaaaat aatgagggtc tagaaagggg aatcttatga 362941 agctgtcgga actgaaaact agcggtcatc cactcacttt gctctgttcc tttttatact 363001 ttgatgtcag ttttatgata tgggttatgc ttggggcgct gggtgtttat atttctcagg 363061 attttggcct gtctcctttt gagaaagggc ttgtcgtagc tgtgccgatt ttatctggat 363121 ctgtgtttcg tatcattctt ggtattttaa cggacagaat cggaccgaaa aaaacggcag 363181 tgatcgggat gctggtgacg atgattccgc tgctttgggg gacattcggc ggccgttccc 363241 tgactgagct gtatgccatc gggattctgc ttggcgtggc gggagcaagc tttgctgtag 363301 cgctgcctat ggccagccgc tggtatccgc ctcatttgca gggacttgcg atggggattg 363361 ccggagcggg gaacagcggc acgttgtttg caaccctgtt tggccctcgt ctggcagagc 363421 agttcggctg gcacattgtc atgggaattg cgctaattcc attattgatc gtctttattc 363481 tttttgtatc catggcaaag gattcccctg cacagccgtc tccccagccg ctcaaaagct 363541 atctgcatgt gtttgggcaa aaggaaacat ggtttttctg cctgctgtac agcgtcacat 363601 ttggcggatt tgtcgggctc tcaagctttt tatctatttt ctttgttgat caataccagc 363661 tgtcaaaaat tcacgcaggg gacttcgtta cattatgtgt ggcggcgggg agctttttcc 363721 ggcctgtcgg gggcttgatt tcagatcgtg tcggcggcac gaaagttctt tctgtattgt 363781 ttgtcatcgt ggcactgtgt atggccggag tcagtagcct gccatctctc tcaatggtta 363841 ttgttctatt gtttgtcgga atgatggggc tcggaatggg aaacggcgca gtattccagc 363901 tcgtgccgca gcgcttccgc aaagaaatcg gcatggtgac gggaatcgtc ggtgcggccg 363961 gaggaatcgg agggtttttc ttgccgaaca tcttaggatc tctcaaacag atgacaggca 364021 catatgctat cggttttatc acgttttcct gtatcgcgct gctggcgttt gcacttgtgc 364081 ttgccgcagg ctattactgg cggaaaagct ggagcgcgga aagcagcccg gcggatgttt 364141 aggattttga cggacacgcg tttgtgcgtg tcttttttat tttctcttga ttttcaacag 364201 tgaaccgatc aaaataaata gtaattatta cgatttgtta gtgagaggag ttttctgaat 364261 gaatcaacat acgctgctcc cgaaaaaaac ggagcgtctt caatactttg gatcggtcag 364321 tccgatcaaa ggcgagaaac cagtggaaaa agagaaaatg aaggacctgc aaaatatcag 364381 gaaggattat ttttttgaca ttcagcatgt aggtgtagct aatgtgtccc atccagtcac 364441 aatcacttct gccatgatgc ctgccgagca aacaacggct gcgaacttta caatgacttg 364501 taatttgccg agaaatcaga aggggattaa catgagccgg ttaacagagc tgctgcaagt 364561 ctatcatcaa aatggctgga ttctctcatt ttcctctctt cagcaattta cgaaagagct 364621 tgcagaaaac atggacacat catctgccac agttgaagtg aggtttccgt ggtttttcga 364681 acggaaaagc ccgaagcttg agaaagcggg tttgatgcat gctgatatat tcatgtctgt 364741 cacctatcgc aaagatcagc cgtttaaaca gcgtgccggc atctcagcaa aagtaacgac 364801 tctgtgccct tgctccaagg aaatcagcga atacagtgcc cataatcaga ggggaacggt 364861 cagcatttgg gcggatattc acccggccgc atcgctgcca agtgatgtta aagctgattt 364921 gcttcacgcc gcagaatcaa atgcttctgc gagactgcat ccggtattga agcggcctga 364981 tgaaaaagcc gtgacagaaa cggcctatga aaacccgaga tttgttgagg atctcgcccg 365041 gctgattgct gcagatttgt ttgagcttga atgggtgtca gcctttgaga ttgaatgccg 365101 aaatgaagaa tcgatccatc ttcacgatgc ctatgcgaag ctgtgttttt cgaaggaagt 365161 ggataaaata tgaaactctc attattcatt attgcagttc ttatgccagt catcctgctg 365221 tcagcctgct ccgatcatgc agaagaacac gcaagtatca atacaaagaa aacggtcgaa 365281 aacataacgg acgttcgaaa aacagcaaaa acaagcattg attggacaaa gccttcgggc 365341 ggagaatacc cggatattaa acagaagcat gtctggattg atgtgaatgt gaaggagcag 365401 aaggcttaca tcaaggaagg aagcaacacc atctatacaa tgatgatttc ttctggtctt 365461 gatcaaacaa aagatgatgc tacgccaaag ggcacctttt atgtagagcc tgaacgggga 365521 gaatggtttt tctccgaagg ataccaggaa ggcgcagaat actgggtatc atggaaaaat 365581 cacggtgaat ttttatttca tagtgtgcca atgactaagg atcaaaaagt catcaaaacg 365641 gaagcagaaa aactaggaac gaaagcatct cacggatgta tcaggctgac cattccagat 365701 gcgaaatggg tatatgaaaa tatccctgaa catacaaaag tggtgatcag ctgaattgaa 365761 aaccgttgac aaaaaggaaa aaagaccata caatttaaat cgtaacaatt acgttttatg 365821 ataaatggct tatcattgtc tgtgcatctg tgaaaagcgg aaaggcatcg attaaggatc 365881 ttgctgtcgg caaaggcaag gatttgcgat ggggaaaagg attaaacgcg gttggagtct 365941 ttactgattt agaaatcggg cggcagcgag aaatgagcgc gaaaagctgc tctacaccat 366001 tgtacatacg gcgaagtatt caatttaaat cgtaatcatt ctattttaat ggaggcacta 366061 ttatgaaaaa aattccggtt accgtactga gcggttatct cggtgcggga aaaacaacat 366121 tgctgaacag cattttgcaa aatcgcgaag gcttgaaaat agcggttatc gtaaacgata 366181 tgagcgaggt gaacattgac gcgggcttgg ttaagcagga aggtggcctt tccagaacag 366241 atgaaaagct tgtggaaatg tcaaatggct gcatttgctg cacgcttcgc gaagacttat 366301 taattgaagt tgagaagctg gcaaaagacg gacggtttga ttatatcgtc atcgaatcga 366361 caggaatcag cgaaccgatc ccggtggccc agactttctc ttatatcgat gaagagatgg 366421 gaatcgatct tacaaaattc tgtcagctgg atacgatggt gacggttgtt gatgccaacc 366481 gtttttggca tgattatcag tcaggcgaaa gccttctgga ccgcaaagaa gcattggggg 366541 aaaaggatga aagagaaatc gccgacctct tgatcgatca aattgagttt tgcgatgtac 366601 tgatcttaaa taaatgtgat ttggtcagcg agcaagagct cgaacagctt gaaaacgttc 366661 ttcgtaaact gcagccaaga gccaggttca ttcgttccgt caaaggaaat gtaaaaccgc 366721 aggagatttt gcatacaggg ttatttaact tcgaggaagc gagcggatcg gccggctgga 366781 ttcaagagct gacggcaggc catgcggaac acaccccgga aacagaagaa tacggtatct 366841 cttcatttgt atataagaga cgtttgccgt ttcattctac acgattttac cgttggttgg 366901 atcaaatgcc aaagaacgtg gtacgtgcca aaggaatcgt ctggtgcgca tctcataaca 366961 acctcgcttt gctgatgtcg caagcaggtc cgtcggttac gattgagcct gtatcttatt 367021 gggtggcggc gttgccgaag cttgagcagg agcaagtcaa acagcaggag ccggaaatcc 367081 tggaggagtg ggacccggag ttcggcgacc gcctaacgca gctagttttt atcggaactg 367141 acctggatga agaaacgatc acgaaagagc ttgatcaatg cctgttgact gagtatgaat 367201 ttgattccga ctggtcgctg tttgaggacc cgtttaaatg gaagctgaat caatagaaaa 367261 aaagccgtcc catggggaac ggcttttttt aatgaaacgt ttgtttaaac ataatgagcg 367321 tattttttct caaggatatt ctgaaagacc gcggcaatgg agcagatggc ccaataaatg 367381 agagcggtca gaatatacat ggtcatataa tcaaactctc tgcccccgat gattttcgca 367441 tgctggagca attccggcac tgtaatcatc gcagcgagag aggacgcctt gatcaagtcg 367501 agcaatacat tggcaagcgg aggcagcgca atacgtatcg attgcggcaa aatgatgccc 367561 ctcatcgtct gccaatagga aagacccagc gaggatgcgg cttcccactg tcctttttcg 367621 acggatgaaa tggctgaacg gttaatttcc gcaatgtagg cggcgctgtt taggctaaag 367681 ccgattaaag cagccgtgac agcggaaaat tcaatgccga tataaggaaa cccgaaataa 367741 aggataaaca aaatcaccaa aatcggaacg cctcgcataa atgagatata gagcttcgcc 367801 ggccatctta acaaagcaag tttagacatt ctggcgagtg atatgaacag gccgatcaca 367861 gttcccgcaa acatgcttac aaaagagatg agcagtgtat aaccaatgcc ttttatgaca 367921 taagggaacg attcaatggc cagcttcgtg ttgaaaatat attcccactg aatgctattg 367981 atcatggcgt ccgattacaa atcaacgtcc tgaacgtcgg catcaatttt ttttgataca 368041 tctgctttat tgaagaattg tttcgacagt ttagtcaaag agccatcctt gctcatctct 368101 ttcaatgctt cgttcatctt tttctgaagt gccgcattgc tttttttcat gacaagggcc 368161 tgtttgttcg gcatgtactt gatgtcagga tgaattgtaa tgttgagatc cgggaatgcc 368221 gcgagcgcaa gtgtctgcag gtaatagtcg tttaaaatga cgtcagtgcg tccgttggca 368281 acatctttta aatattgctc attcgtcgca ttatcataaa tcacttcttt ggcgccgtat 368341 tttctcgcga cctccatgta gacggttgta gccgcgccag ccgctttctt cccttttaaa 368401 tccttgagcg ttttaatccc tgataaatcg tcttttcgga caattgccgt gccgtatgaa 368461 tatttatatg gagtggaaaa tgcgaacttc tcctcacggt ccttcgtcac atcgatgtca 368521 ttcgcggctg cgtcaacctg tccgctgttc accgctgtca gcatcccgtc aatgcccatc 368581 tccttgaact caaccttcag ccccaagcgt tttgccgctt cacgaacaac ttcaacctcg 368641 tagcccgtca gcttatcaga gccagagtca gtatcgtgat aagaagtggg atagagcgta 368701 cctgatgtag cgactacgat tttcccttta tccttaatct gctcccagcc tgtatccttg 368761 gaatcggctt catttttgcc ggaacaggct gccaatataa gaaagaaagc cattgtgaaa 368821 ctgaatataa cggctttgga atgcatgaat gatttcacct atagttcccc caatctgtta 368881 atcaactaaa aagatagcat tgaacataag gggttgcaat atgttgatcg cgttttcaaa 368941 aagttcgaat tgtgtataca aaaagcatgg gtgggtgttt aaaagcgtct atgaagggaa 369001 gaggtgatga aaaaaggaat tgtccaagga tgaatgccag acgtaccaag gaaacgcatg 369061 tgaaagtgaa ggatgcagca gacccgtcac tcatctatgc caataccgga agaaatggtc 369121 aagaggcatg aaaccgatct tcagaataaa tttaagtctt gctgatgccc ctaaggcata 369181 tgatatattc gatgagaaag aaaatggaaa catttaaacc ataatgggga gtcaaatgaa 369241 tatttacaaa ccagccggat tttggatcag acttggagct gcattgttag actacattat 369301 agtctccgtg ccgcttttgc tgatctattg gctgattaca ggaaaagacc caaacgacag 369361 catgttcatc agtttggttg ttctgctgta ttctattttg ctgccgatgt tttggcgcgg 369421 ttatcttatc ggaaaaagga tctgcggaat cagaatcgta aaaaaagacg gatcacaggt 369481 cagtctgtta acaatgtttt tacgggttat tgtagccggc ctggtttact gtataacctt 369541 cggactcggc ttgatcgcca gcctgattct gattgccgta cgagaagaca aacggaccct 369601 gcatgattta atcgcgggaa catatgtcac ttatgcgaca ccaggtgaag aggaacttaa 369661 tgctgacgaa gagattagaa agagcgaata atggttcgct ctttttattt ttatgcataa 369721 aaaatacaag gcagcaaaac atatgaaaaa taggattgga ggaataaaat ggatgaaacg 369781 aataaccatc aacattatca caatgttcat tgcagcggct gtcatttctc tgaccggtac 369841 agctgaggcc gctgaaaaac agcagcagtc tcccgcaaat gttacactga cagatcagca 369901 aaagaaagag attgaacaac tggaagcaga gattcttaaa aagcgcaaag acgtgatctc 369961 aaagtatgta caatacggta tcctgcctaa agaaagagga gaacacatca aaaatcactt 370021 ggacaaacac tttgaaatga tgaaacaaaa cggctttgtt ccaaagcacc atcctcatcc 370081 gcataaattt gaaaaaagac attaagattt taagcatcca atgggaattg ggtgcttttg 370141 cgttatttac aggtaggcaa tattagctga gctgttccgc gactaacatc gagttgatat 370201 gaaacgcgtt tcatagccta tgataggttt atcaaataat tcaggagtga taaacactat 370261 gatccaccag catccagaat cttttccgaa acattttttg tggggctctg cttctgcagc 370321 gtaccagatt gaaggcgctt ggaatgaaga tggcaaaggc ccttctgttt gggatgtgtt 370381 tacgaaaata ccgggcaaaa cgtttaaagg aaccaatggc gagattgcgg ttgaccatta 370441 tcaccgattt aaagaagatg tcgctctgat ggctgagatg gggttaaaag catatcgatt 370501 ttccgtcagc tggccacggg tttttccaaa aggaaaagga gagatcaatg aagcaggtct 370561 agcgttttac gatagtctga ttgatgaatt gctttctcat cacatcgagc cggttctgac 370621 tttatatcac tgggatttgc ctcaagcgct tatggacgaa tacggcgggt ttgaatccag 370681 aaacatcata gaggatttta atcactactg tattactctt tataaacgtt ttggagacag 370741 ggtgaaatat tgggttacgt taaacgaaca gaactacaat tttaatcacg gatttattac 370801 agccatgcat ccgcctggag tgaaagacag aaaacgattt tacgaagcaa accatattgc 370861 gtttctggct aatgcaaaag ccatcgaatc atttagagaa tatgtgcctg aaggcaaaat 370921 aggtcctagc tttgcttatt ctccggctta ccctttatca agtcatccag aggatatact 370981 ggcatttgaa aacgccgaag aatttacgaa caattggtgg cttgacatgt attgctgggg 371041 aacctacccg caaattccat tccgctgctt ggaaaaacag ggatgggcgc cgacaattga 371101 agcaggagat atggacctgc tcgccaaagg gaagcctgat tttgtaggtg tcaattatta 371161 tcagacgatc acctatgaac gaaatccgct tgatggtgtg tcagaaggga aaatgaatac 371221 gacaggccaa aagggaacca atcaggagac ggggataccc ggagtgttca aaacgaaaaa 371281 aaatccgcat ctgacaacga gcaactggga ttggacaatt gacccaattg ggctgcgtat 371341 cggtcttcgc cgaattacaa gccgctatca gcttccagtg tttataacag agaacggttt 371401 gggtgaattt gataaagttg aggacggcac tgtacaggat gattatcgaa ttgattattt 371461 gcgttcgcat cttgagcaat gcagacaagc catcagtgac ggtgtcgatt taatcggcta 371521 ttgcagctgg tcgtttactg atctgttaag ctggctgaac ggctaccaaa aaagatacgg 371581 atttgtatat gtcaatcgtg atgaagaaag cacatccgat ttaaaacgct tgaagaaaaa 371641 aagcttttat tggtatcaag atgtcatcaa gacaaacgga gaaagtttat aaagagtccc 371701 tgagagttat tctctcaggg gtttttcatt acacagaaac agcatcaata atataagtgt 371761 cggcgtgcaa atctgacatt tcagccggca cagtccagca tgtcaattga tagtctcctt 371821 taggcagatc aaaggacagt cttttagaca tgatgctttc aatatgaatt ccgttttctg 371881 tgacatgaaa aggaacagtc actttttttt cgtaggagtt tactgtttct gaactgttca 371941 ggcgaaaaag aataaaggcc tttgtatttc gctgtgcctc aaaggaaatg gctccgtctg 372001 ccgcagcata tcctttttca atcgcttcgt cagtccaatc cattacagga ggtgtagaat 372061 ccttttgaaa tacagtaaat tgatgatatg aaatcgaaag ttcttgcggc ttccatgatt 372121 tgatcaatgt gctgttcctc ctctatgtac tgtttactga attgtgaata aaacctttgt 372181 gccgtctggg taatcggtaa gccgatgccc gacccaagag cctgctccgc ggttgtcagc 372241 gggagaaatg tattctacag aagctccctc accgccttct ttgcacatgg ccattggcca 372301 ttcatctctg tcatacccct ttttggaagg tacgtccttt aatgattgct cgcggcgttc 372361 ttcagctccg tctctgtcaa tagtgcacac ctctgagtgc ccctcattta tcgcatcctt 372421 aatatgcttg gcagtttcgg gataccggtc agatgggaag gccattgttt catcatattc 372481 tttcgtttga gacgtttttt gatcagctga gaaaaagtct ccttttatca ggccgacagc 372541 tgcagctgct atgatgacga tgacgagaag tatcgttttt atgatgtccg tcgtgatgtt 372601 cacctcccgc ttttaaaact gacacaagag taatccagaa agcatttggt gtaaaggttt 372661 aaattttatg ttttacgatc agtttattgc agaaatcgta attttagcag atcgaaatat 372721 ttgttttcag caaaatacga ttgccaattt acaataatga tagtaagtca tcagccgttt 372781 tcggcttgat taatcatttt aaattggctt atgataccgg taagctcctc agctaattga 372841 gaaagtgttt cagaagctgc ggtaatctcc tccattgcag caaattgctc ctctgttaat 372901 gcagccgctt gccgggtatt tttagtagat tctttaatgt cggccgtatt ggctgcaaag 372961 gaatcattta tttgatgtgc actggctgaa atgtttgtta cagatgctga taaatcacta 373021 atctcggcgc tgatttcacc tgttgcagct gcaatttcct taaatgcatc tctggtgcgc 373081 tggatcatgg tgactccttc tgcagcttct gttttcacat gctcaacaga tcttgcagac 373141 cggttcatat ccttttgtat ttctatgatc agttttgaaa tctgccccgc agactgttga 373201 gactcttctg ctaatttccg tacttcatca gcaacaacag caaagccttt tccttgttca 373261 ccggctctgg cagcttcaat cgctgcattc agcgcaagca ggtttgtctg atcagcaatt 373321 tgggtgatga ccgataaaat ttgctcaatt tgtttagagc ggccgtctaa ctggtgtatg 373381 atttctccgc ttttctgaat tgactggtga atcgcatcca tttgcgcctg tacatttgca 373441 atttcctttt gtccaatgtc tgcttttgat tgagcgagct gccctttgtc agcgatagcg 373501 gcagtatttg cagaaatatc ccggatgtct gctgaagctt gttttaatga gctttcacta 373561 ttttcaattc gggtgatctg atcttgggct ccatttgcaa tctgctgtac agcttctgtg 373621 attttttctg aagcttgatt tgtttcctct gctccggctg agagctgctg agaggctgac 373681 gcaagctgaa gggctgattg ttgtacggtt tgtatggtat cgttcagctt cattctcatc 373741 ttattataat agacgcttag ttctgaaagc tcgtcaccgg ttttgtctga cacctctatt 373801 gtcatatctc cgtttccggc actttcaaag gcgcttttta aagcgttcag ccgcttgttg 373861 atttttctgg tgaaaaccaa gacaaggatg actgatacca taatgacgat aacaagaacg 373921 atagcgaatt gagtgaaaag tgattgtgta agtgatgcta aaatactttg attagctccg 373981 gtatacagca tgccgatgat gttcccattt tgatctttta acggcatgta tgcagtctga 374041 taagaagaac ctgctacatc tgcttgtccg taaaaacgct ttcctttctt taaaacagcg 374101 gcaataactt cagaagaagc ctgggtgccg acggctcttt cgccattttt catgacattg 374161 gttgcaacac gagtatcgcc ttggaaaatg gtaatggtat cacctgtctt ttcaccaagc 374221 agatcaacaa tatcttcatt tccattgatt tgtgtttgcc ctttatagag cttattgttt 374281 ttcacctgcc agtcgcctga catgacatca tcaatataag tgctgcttaa agcgagatca 374341 cctttcgctt tttcagttgc catttgtttc atgctttctg taatttcctt aagcatcaca 374401 gtgccaactg atgccgaaaa caaaagaatc accacgaaaa cgaggcaaag aattttagtt 374461 cctagcttca tcttaaatcg ttttatcaac ataattcctc cctttacgat ttgcaggtca 374521 tattacttat cgggtttttg ggtttaaagt tttattttag aaaaaataaa accggcctga 374581 tcttcaggcc ggttgtgtga tgctattcaa ggtttgcgtg gtgagtgaac atagtttcag 374641 aatcgagacc ttttttctcc atgagtttta aaatcactgc atcatagaag agcagcaaag 374701 tttgttcaaa taatgatccc attggctgaa tggttttata gcttccgtta gactggtctt 374761 taggggaacc aggcattctg atgatgaggt ccgcttgttt tccgatgctt gattccggat 374821 tgatggttaa agcggcaaca attccgtgta agctttttgc ttttgctgcg gtatgaatca 374881 agctctttgt ctcgcctgat cctgagccga taataactag atctccttcg gcgagcggcg 374941 gagtgagaat ctcacctact atatgggcgt tgaagcccat gtgcatcagt ctcatcgcga 375001 aggattttgc catcaggcca gaccgccccg cacccgcggt gaaaatttgg tgggatgaaa 375061 gaatgtgatc ggcaagctgg tcagcttctt cattagaaat ataagctgct gaattgtgta 375121 actcattgag aatttccgct acgtattcag tcgttttcat cggagttatc cttggacaat 375181 cagctgcttc atttttgaag ctgtttccgc cttatcagct gcgcttgtaa ttccgccccc 375241 gacaatgaca aggtcaggct tttgctggat cacttctggc agtgtatcaa gtttgatgcc 375301 gcccgcgatt gcggtttttg cgttttttac ggtatttttg attgtcgtta attcttcgaa 375361 agagtttttg ccctctgctt gaagatcata gccagtgtgg acgcagatgt agtcaacacc 375421 gagtgcgtca atttctttcg cacgggattc gatatctttc acgttaatca tgtccactaa 375481 gattttcttc ttttgttttt tggcttcttc tactgcgcct ttaatcgttg catcgtctgt 375541 agcccctaaa acggtgatga tgtcagcgcc tgcttccgac gctttcataa tttcgtagcc 375601 tccggcatcc atgattttca ggtctgcaag aaccttcaat tgaggaaatg cttcttttat 375661 ttctttaacg gctcttaggc cttcattgat gacgaccggt gttccgattt caactacgtc 375721 gatgtattgt tctacctctt tgacaagctc aatggcttcc gggatgttga cgaggtctaa 375781 tgcaagctgt aattccattg ttgatccact ccctttttcg aattattgtt cattctatag 375841 gttccttctt ttgttgagaa gtaggcactt tgaagtcaac aagttacttg gaggatactg 375901 tgaggagaga caatcagatt tctttcgctt gattttatga gtgagtataa tgaaaaaaga 375961 gtctgcaaaa aagtaagtaa gtgatgatac gtatctaaca tacaaaaagg ttactaaggg 376021 gggggattct attgagccgg atggacgaca aaaggtttaa ttgtgagaag gaattaacgc 376081 ttgcagtgat tggcggtaaa tggaaaatgc tcattttatg gcatttagga aaagaaggca 376141 caaaacggtt caatgaatta aaaacattga ttcctgatat tacgcagaag atcctcgtga 376201 atcagctgag agagcttgag caggatatga ttgttcacag ggaagtgtat ccagttgtcc 376261 cgccgaaggt tgaatattct ctgaccccgc acggagaaag cctcatgcct attcttgaag 376321 ccatgtatga gtgggggaaa ggctatatgg aattgattga tatcgacaaa aatgtcatga 376381 aagaatcgtt gtaagacgct cttcgcaagg gtgtcttttt ttgccttttt ttcggttttt 376441 gcgcggtaca catagtcatg taaagattgt aaattgcatt cagcaataaa aaaagattga 376501 acgcagcagt ttggtttaaa aatttttatt tttctgtaaa taatgtttag tggaaatgat 376561 tgcggcatcc cgcaaaaaat attgctgtaa ataaactgga atctttcggc atcccgcatg 376621 aaacttttca cccatttttc ggtgataaaa acattttttt catttaaact gaacggtaga 376681 aagataaaaa atattgaaaa caatgaataa atagccaaaa ttggtttctt attagggtgg 376741 ggtcttgcgg tctttatccg cttatgttaa acgccgcaat gctgactgac ggcagcctgc 376801 tttaatagcg gccatctgtt ttttgattgg aagcactgct ttttaagtgt agtactttgg 376861 gctatttcgg ctgttagttc ataagaatta aaagctgata tggataagaa agagaaaatg 376921 cgttgcacat gttcactgct tataaagatt aggggaggta tgacaatatg gaaataactt 376981 tttacccttt aacggatgca caaaaacgaa tttggtacac agaaaaattt tatcctcaca 377041 cgagcatttc aaatcttgcg gggattggta agctggtttc agctgatgcg attgattatg 377101 tgcttgttga gcaggcgatt caagagttta ttcgcagaaa tgacgccatg cgccttcggt 377161 tgcggctaga tgaaaacggg gagcctgttc aatatattag cgagtatcgg cctgttgata 377221 taaaacatac tgacactact gaagatccga atgcgataga gtttatttca caatggagcc 377281 gggaggaaac gaagaaacct ttgccgctat acgattgtga tttgttccgt ttttccttgt 377341 tcaccataaa ggaaaatgaa gtgtggtttt acgcaaatgt tcatcacgtg atttctgatg 377401 gtatctccat gaatattctc gggaatgcga tcatgcacat ttatttagaa ttagccagcg 377461 gctcagagac aaaagaagga atctcgcatt catttatcga tcatgtttta tctgaacagg 377521 aatatgctca atcgaagcgg tttgaaaagg acaaggcgtt ttggaacaaa caatttgaat 377581 cggtgcctga acttgtttcc ttgaaacgga atgcatccgc agggggaagt ttagatgctg 377641 agaggttctc taaagatgtg cctgaagcgc ttcatcagca gattctgtcg ttttgtgagg 377701 cgaataaagt cagtgttctt tcggtatttc aatcgctgct cgccgcctat ttgtacaggg 377761 tcagcggcca gaatgatgtt gtgacgggaa catttatggg caaccggaca aatgcgaaag 377821 agaagcagat gcttggcatg tttgtttcta cggttccgct tcggacaaac attgacggcg 377881 ggcaggcgtt ttcagaattt gtcaaagacc ggatgaagga tctgatgaag acacttcgcc 377941 accaaaagta tccgtataat ctcctaatca acgatttgcg tgaaacaaag agctctctga 378001 ccaagctgtt cacggtttct cttgaatatc aagtgatgca gtggcagaaa gaagaggatc 378061 ttgccttttt gactgagccg attttcagcg gcagcggatt aaatgatgtc tcaattcatg 378121 taaaggatcg atgggatact gggaaactca ccatagattt tgattaccgc actgatttat 378181 tttcacgtga agaaatcaac atgatttgtg agcgcatgat taccatgctg gagaacgcgt 378241 taacgcatcc agaacataca attgatgaat taacactgat ttctgatgcg gagaaagaga 378301 agctgcttgc gagggccggc ggtaaatctg tgagctaccg taaggacatg acgataccag 378361 agctgttcca agaaaaggct gaactgcttt ctgatcatcc agcggttgta tttgaagatc 378421 gcacattgtc ctatcgaacg ttacatgagc aatctgcacg catcgccaat gtgctgaaac 378481 agaaaggggt tggcccggac agtcctgtcg cggttttgat tgaacgctct gaacggatga 378541 ttacagctat catgggaatt ttaaaagccg gcggagccta tgtgccgatt gatccgggtt 378601 ttcctgctga gcgcattcaa tatattttgg aggactgcgg ggcggatttc atcctgactg 378661 aatcgaaggt tgcggcgcct gaagccgatg ctgagctgat tgacttagat caggcgattg 378721 aggaaggtgc agaagaaagc ctgaatgcag atgtgaacgc tcggaacctt gcctacatta 378781 tttacacatc gggaacaacc ggacgcccga aaggcgttat gatcgagcat cgccaggttc 378841 atcatttggt tgaatctctg cagcagacga tttatcaaag cggcagccaa accctgcgga 378901 tggcattgct tgcgccgttc cactttgatg cgtcagtgaa gcagatcttc gcgtcgcttc 378961 ttttgggcca aaccctttat atcgtaccga agaaaacagt gacgaacggg gccgccctta 379021 ctgcatatta tcggaagaac agcattgagg cgacggacgg aacaccggct catttgcaaa 379081 tgctggcagc agcaggcgat tttgaaggcc taaaactgaa gcacatgctg atcggaggag 379141 aaggcctgtc atctgttgtt gcggacaagc tgctgaagct gtttaaagaa gccggcacag 379201 cgccgcgttt gactaatgtg tacgggccga ctgaaacgtg cgttgacgcg tctgttcatc 379261 cggttatccc tgagaatgca gttcaatcag cgtatgtgcc gatcgggaaa gcgctgggga 379321 ataaccgctt atatattttg gatcaaaaag gccggctgca gcctgaaggc gtggcgggtg 379381 agctttatat cgcgggagac ggtgtgggcc gaggctattt acatttgcct gaattaacgg 379441 aagagaagtt tttacaagat ccattcgtgc cgggcgatcg catgtaccgg accggggacg 379501 tggtgcgctg gcttccagat ggaacaatcg aatatttagg cagagaggat gaccaggtca 379561 aagtccgcgg ataccggatt gagcttgggg aaattgaagc cgtgattcag caggcgccag 379621 acgttgcaaa agccgttgtt ttggcacgcc ctgacgaaca gggaaatctt gaggtttgcg 379681 catatgttgt gcagaagcct ggaagcgaat ttgcgccagc cggtttgagg gagcatgcgg 379741 ccagacagct tcctgactat atggtgccgg cttactttac agaagtgaca gaaattccgc 379801 ttacaccaag cggcaaagtc gaccgccgca agctgtttgc actagaggtg aaggctgtca 379861 gcggcactgc ctatacagcg ccgcgaaatg agactgaaaa agcaatcgca gccatttggc 379921 aggacgtgct gaacgttgag aaggcgggga tctttgacaa tttctttgaa actggcggac 379981 attcattaaa agccatgacc cttttaacaa agattcataa ggaaacaggc attgagattc 380041 cgcttcaatt tttgtttgag catccgacga ttacggctct tgcagaggaa gctgatcaca 380101 gagaaagcaa agcttttgcg gtgattgaac ctgctgaaaa acaggagcat tacccgcttt 380161 cattggcaca gcagcgaaca tatatcgtca gccagttcga ggatgcggga gtcggctata 380221 acatgccagc agcagcaatt ctggaagggc ctttagatat tcaaaagctg gagcgcgcat 380281 ttcagggatt aatccgacgc cacgagtcat tgagaacatc atttgttctt gaaaacagca 380341 cgccgagaca gaaaattcac gatagcgttg atttcaacat cgaaatgatt gaaagaggcg 380401 gccgctcaga tgaggcaatt atggcttcat tcgttcggac atttgatttg gcgaaagctc 380461 cgctgttcag aatcggtttg ctggggcttg aagagaaccg tcatatgctg ctgtttgaca 380521 tgcaccattt gatttctgac ggtgtatcca ttggcattat gctggaggag ttagcacgca 380581 tttataaagg cgaacagctt cctgatcttc gtctccagta taaggactac gctgtatggc 380641 aaagcagaca ggctgctgaa gggtacaaga aggaccaggc ttattggaag gaagtctttg 380701 caggcgagct cccggtgctt cagcttctgt ccgattaccc aagaccacct gttcaaagct 380761 ttgaagggga tcgggtgtca atcaagctgg atgcgggggt aaaggatcgc ctcaatcgtt 380821 tggctgaaca aaacggcgcc actttatata tggtgatgct ttccgcttac tatacgcttt 380881 tgtcaaagta tacggggcag gatgacatca ttgtcgggac accgtcagcg ggcagaaatc 380941 actccgatac agagggcatt atcgggatgt tcgtcaatac gcttgcgatt cgcagtgagg 381001 tgaagcagaa tgagacgttt acccaattga tctcgcgtgt ccgcaaacgg gtgctggatg 381061 ccttttctca tcaggactat ccgtttgagt ggcttgttga agatttgaac atcccgcgtg 381121 atgttagcag gcatccgctg tttgacacga tgttcagcct tcaaaacgcg acagagggca 381181 ttccggctgt cggcgatctt tccttgtctg ttcaagagac caatttcaag attgccaaat 381241 ttgatttgac ggtgcaggcg agagaaaccg atgaaggcat tgagattgat gtggattaca 381301 gcacaaagct gtttaaacaa agcacggcag acaggctgct tacgcatttt gcgcgtttgc 381361 ttgaagatgc tgcggctgat ccagagaagc cgatttctga gtataagctt ctttctgaag 381421 aggaggctgc ttcgcaaatt cagcagttta acccgggcag aacaccttat ccgaaagata 381481 aaacaattgt tcagctgttt gaggagcaag cggcgaatac gccagaccac actgcgcttc 381541 aatatgaagg cgaatcactc acttatcgtg aactgaatga acgggccaat cgtttagccc 381601 gcggcattct ttctcttgga gctggcgaag gcagaactgc ggctgtctta tgcgagcggt 381661 caatggatat gattgtgtcg atcttggcag tattaaaatc aggttcggct tatgttccga 381721 tcgatccgga acatccgatt cagcggatgc agcatttctt ccgtgacagc ggagcaaagg 381781 tgcttctcac tcagaggaaa ttaaaggctt tggcggaaga agcggaattt aagggcgtta 381841 tcgtgctagc cgatgaggaa gaaagctatc atgccgatgc gcgaaatctc gcactgcctc 381901 ttgattctgc agcaatggcc aacctgacgt atacttccgg aacgactgga acacctaagg 381961 ggaatatcgt gacacatgcc aatattctcc gcacggtgaa ggaaacgaat tatctcagca 382021 ttacagaaca ggatacgatt ctcggtcttt ccaattacgt gtttgacgcg tttatgttcg 382081 atatgttcgg ctctttgtta aacggagcca agctggtgct gataccgaag gaaaccgttt 382141 tggacatggc tcgcctgtcc cgcgtcattg aacgggagaa catcagcatt ctcatgatta 382201 caaccgcttt gttccacttg cttgtggact tgaatccggc atgcttgtca acgcttcgca 382261 agattatgtt tggcggggaa cgggcttcgg ttgagcatgt cagaaaagct ttgcaaacgg 382321 ttggaaaggg caagctcctt catatgtatg gaccgtctga aagcacggtt ttcgcgacgt 382381 atcatccggt tgatgaattg gaggagcaca cgctgtctgt tccgattgga aaaccggtca 382441 gcaatacgga agtatacatt cttgaccgta cgggacacgt gcagcctgcc gggattgccg 382501 gagagctttg cgtcagcggc gaaggactcg tgaaaggcta ttacaaccgt ccagaactga 382561 ctgaggagaa atttgttccc catccgttta catccggcga acgcatgtat aaaacgggag 382621 accttgcgag atggctgccg aatggcgaca tcgaatttat cgggcgaatc gaccatcagg 382681 tgaagattcg cggacagcgc atcgagcttg gagaaatcga acatcagctg caaacccatg 382741 atcgtgttca ggaaagtgtt gtgcttgccg ttgatcaagg agcgggagat aaactgttgt 382801 gtgcttacta tgtcggagaa ggagacatct catcacaaga gatgagagag catgctgcga 382861 aggacttgcc ggcatatatg gttcctgcgg tgtttatcca aatggacgag ctgccgctga 382921 cagggaacgg aaaaattgac cggagagcgc tgccgattcc tgatgccaac gtttcaagag 382981 gtgtttcata tgttgcgcca cgcaatggaa cggaacaaaa agtcgcggac atttgggcac 383041 aggtacttca ggcagaacaa gtcggcgctt atgaccactt ctttgacatt ggcggacatt 383101 cattagcagg catgaagatg cttgccttgg ttcatcagga actgggcgtt gagctgtcac 383161 tcaaggatct cttccagtca ccgacggttg agggcttggc acaggtgatt gcctctgctg 383221 aaaaagggac agccgcaagt atcagcccgg cagagaaaca agatacgtat cctgtttctt 383281 caccgcaaaa acggatgtac gtgcttcagc agcttgagga tgcgcaaacg agctataaca 383341 tgccggcggt tctgcgcctg acaggtgagc ttgatgttga aaggcttaac agcgtcatgc 383401 agcagttaat gcagcgtcat gaagccttga gaaccacgtt tgaaataaaa gatggagaaa 383461 cggtgcagcg gatctgggaa gaggctgagt gcgagatagc ctatttcgaa gccccggaag 383521 aagagacaga gcggatcgtt tctgagttta ttaagccttt caaaatcgac caacttccac 383581 tgttcagaat agggcttatc aagcattcag acactgagca tgtgctgctg ttcgatatgc 383641 atcatattat ttctgatggt gcatctgtcg gtgtgctgat tgaggagctt tcaaagctgt 383701 acgacggaga aacccttgag ccgctccgta ttcaatataa ggattatgcc gtgtggcagc 383761 agcagttcat tcagtctgag ctttacaaga agcaagaaga gcattggctg aaggagctgg 383821 acggagagct gccggtgctg acgcttccga ctgattacag tcggcctgcc gttcaaacat 383881 ttgagggaga ccgcattgca ttttcattag aagcaggcaa agctgatgct ctgcgcaggc 383941 ttgcaaaaga aacggattcc acgctttaca tggtgcttct ggcttcatac agtgcgtttt 384001 tatcaaaaat tagcgggcaa gacgatatca tcgtcggttc acctgtggcc ggacgatctc 384061 aagcggacgt cagccgcgtc atcggaatgt tcgtcaatac attggcgctg cgcacgtatc 384121 cgaagggtga aaagacgttt gctgactatc ttaacgaagt gaaagaaacg gcactcagcg 384181 cttttgatgc gcaggattac ccacttgagg atttgatcgg aaatgttcag gttcagcgtg 384241 acacaagcag aaatccgtta ttcgatgcag ttttttcaat gcaaaatgcg aatataaagg 384301 atttaacaat gaaagggatt cagcttgagc cgcatccgtt tgaacggaaa acagccaagt 384361 ttgacctcac gctgacggct gacgaaaccg acggagggct tacattcgta ctcgaataca 384421 atacagctct gtttaagcag gaaacgattg aacgatggaa gcaatattgg atggagcttt 384481 tagatgcagt tactgggaac ccgaaccagc cgctttccag cctgtcactg gtcaccgaga 384541 cagaaaagca agcgcttctt gaggcatgga agggcaaagc gctgcctgtg ccgacagaca 384601 aaacggttca tcagctattc gaagagactg cccagcgcca caaagaccgc ccggctgtca 384661 catacaacgg ccagtcttgg acgtacggcg agctgaatgc gaaggcaaac cgtctcgcgc 384721 ggattctgat ggactgcggc atcagcccgg atgaccgcgt cggcgttctc acgaagccgt 384781 cgcttgaaat gtccgccgcg gtgctcggcg tcttgaaagc cggagcggcg tttgtgccga 384841 ttgatcctga ctatccggat cagcggattg agtatatttt acaggacagc ggcgcgaagc 384901 ttctcttgaa acaggaaggc atttcagtgc cggacagcta tacgggagat gtcattcttc 384961 tcgacggaag ccgcacgatt ctaagcctgc cgcttgatga aaacgacgag gaaaatccag 385021 aaaccgctgt aaccgcggag aacttggcgt acatgattta cacgtctgga acgaccggac 385081 agccgaaggg tgtcatggtc gagcaccatg cgcttgtgaa cctgtgcttc tggcaccacg 385141 acgcgttcag catgacagcg gaggaccgca gtgcgaagta cgcgggcttt gggttcgacg 385201 cttccatttg ggagatgttc ccgacctgga cgatcggtgc cgaacttcac gtcattgagg 385261 aagcgatccg cctcgatatc gtccgcctga acgattattt tgaaacgaac ggcgtaacga 385321 tcacgttcct gccgacacag cttgcggaac agttcatgga gcttgagaac acatcacttc 385381 gcgtattgct tactggagga gacaagctga agcgcgcagt gaaaaagccg tacacactcg 385441 tcaataacta cgggccgaca gagaatacgg tcgttgccac aagcgcagaa atccatccgg 385501 aggaaggctc gctttccatc ggaagggcca ttgccaatac gagagtatac attctcggcg 385561 agggcaatca ggtgcagccg gaaggcgtag ccggagagct ttgcgtggcg gggcgcggac 385621 tggcacgcgg ctatctgaat cgagaagacg aaaccgcgaa gcggtttgtc gctgatccgt 385681 ttgtgccggg tgagcgcatg taccgcaccg gcgatttggt gaaatggacg ggcggcggca 385741 tcgaatacat cggccggatc gaccagcagg tcaaggtccg cggctaccgg atcgagctct 385801 cagaaattga agtccagctc gcccagcttt ctgaggtgca ggatgcggcg gtgacagctg 385861 tcaaagataa aggcggcaac acagcgatcg cggcgtatgt cacaccggaa tcagctgaca 385921 tagaagcact gaaatcagca ctgaaggaaa ccctgccgga ttacatgatc ccggcgttct 385981 gggtgacgct gaacgagctt ccggttacgg caaacggcaa agtggaccgc aaagccttgc 386041 ctgagccgga catcgaagcg ggaagcggag aatacaaagc gccgacgacc gacatggaag 386101 agctgcttgc cggcatctgg caggacgtgc ttggaatgtc tgaagtcggt gtcaccgaca 386161 atttcttctc gcttggcgga gattccatca aaggaattca aatggcgagc cgcttgaacc 386221 agcacggctg gaagctggaa atgaaagatc tcttccagca cccgacgatc gaagagctca 386281 cccagtacgt agagcgtgcc gaaggcaaac aggcagacca aggcccggtg gagggcgaag 386341 tcatcctgac gccgatccag cgctggttct ttgaaaagaa cttcacgaac aagcaccact 386401 ggaaccaatc tgtgatgctt cacgccaaga agggctttga tcctgaacgg gtggagaaaa 386461 cattgcaggc gctgatcgag catcatgacg cgctccgcat ggtctatcgt gagggacagg 386521 aagacgtcat tcaatacaac agaggtcttg aagctgcttc agctcaattg gaggtcatcc 386581 agattgaggg ccaagctgca gattacgaag accgaataga gagagaagcg gagcgtttgc 386641 aaagcagcat cgacttgcag gaaggcggct tgttaaaagc aggcttgttc caagcggaag 386701 acggagatca cttgcttctt gccattcacc acttagtggt tgacggcgtg tcgtggcgga 386761 ttttactgga ggatttcgcc gcggtatata cacagcttga gcaaggcaat gaaccggttc 386821 tcccgcagaa aacacattca tttgcagagt atgcagagag attgcaagac ttcgcgaact 386881 ccaaagcctt tttgaaagaa aaagagtatt ggagacagct tgaagaacaa gctgttgcgg 386941 caaagcttcc gaaagaccgc gaatctggtg atcagcgaat gaaacataca aagacaattg 387001 aattctcgct gactgctgaa gagacagaac agctcaccac aaaggtgcat gaggcatatc 387061 acacagaaat gaatgatatt ttgctgacgg cattcggatt ggcaatgaag gagtggacgg 387121 gtcaagatcg agtaagtgtt catttagagg ggcatggacg tgaagaaatc atagaagacc 387181 tgaccatttc tcgcacagtc ggctggttta caagtatgta cccaatggtg ctcgatatga 387241 agcatgcgga tgatctgggc taccagctga agcaaatgaa agaagatatc agacatgtgc 387301 cgaataaggg agtcggatac ggcattctgc gctatctgac ggcaccggaa cataaagaag 387361 atgtggcgtt ctcgattcag ccggatgtca gcttcaacta tttaggtcag tttgacgaaa 387421 tgtcggatgc aggtttgttt acgagatcag agctgccatc aggacagtca ttaagccctg 387481 aaacagaaaa accgaatgcg ctggatgttg tcggatatat cgaaaacgga aaactgacga 387541 tgtcactggc ctatcattct cttgaatttc atgaaaaaac agtacaaaca ttcagtgaca 387601 gctttaaagc gcatcttctc agaatcattg aacattgcct atctcaagat ggtacggaac 387661 tgaccccgag tgatcttggt gacgacgatt tgacgctgga tgagctggat aaattaatgg 387721 aaattttcta atagaggtgg catatgagca aaaaatcgat tcaaaaggtg tacgcactga 387781 caccaatgca ggagggaatg ctgtatcatg cgatgcttga tccgcattct tcctcgtact 387841 tcacacaatt agagcttggg attcacggcg cttttgatct tgaaatcttt gagaaaagcg 387901 tcaatgaact gattcggtca tacgatattc tccgtacggt atttgtgcat cagcagctgc 387961 aaaaaccgcg tcaggtcgtg ttagcggaac gcaaaacaaa agtgcattat gaggatatca 388021 gtcatgcaga cgaaaaccgc cagaaagagc acattgagcg ttacaaacaa gacgttcagc 388081 gccaaggctt taacctggca aaagacatat tgttcaaggt agcggttttc cgccttgctg 388141 cagatcagct gtatcttgtc tggagcaatc atcatattat gatggacggc tggagcatgg 388201 gcgtcctcat gaaaagcctg ttccaaaact atgaagcgct cagagcaggc aggacaccgg 388261 caaacggtca gggcaagcct tattccgatt acatcaagtg gcttggaaaa caggacaatg 388321 aagaagcgga gagctactgg agcgagcgct tggcgggttt tgaacagcca agcgtgctcc 388381 cgggccgcct gcctgtgaaa aaagacgaat acgtcaataa agaatattca tttacatggg 388441 acgaaacact ggttgcccgt attcagcaaa ccgcaaatct ccatcaagtg acagggccta 388501 acctatttca ggccgtttgg ggcattgttc tcagcaaata caactttacg gatgatgtga 388561 tcttcggaac ggtcgtctcg ggacgaccgt ctgaaatcaa cggaatcgaa acgatggcgg 388621 ggctgtttat caacaccatt ccagtgcggg tgaaagttga acgagatgct gcattcgctg 388681 atattttcac agctgttcag cagcatgcag tagaggcaga gcgttacgat tacgtgccgc 388741 tctatgagat tcaaaaacgc tcagctcttg atggcaatct cttaaaccat ctggtcgcgt 388801 ttgaaaatta tccgcttgat caagagcttg aaaacggcag catggaagac cgcctcgggt 388861 tttcgattaa ggtagaaagc gcatttgaac aaacgagctt cgatttcaac ctgattgtgt 388921 atccgggcaa aacgtggacc gtcaaaatta aatataacgg agccgccttt gattccgctt 388981 ttatcgaacg gacagcggag caccttaccc gcatgatgga agcagctgtc gatcagccgg 389041 ccgcttttgt gcgtgagtac gggcttgtgg gagacgaaga gcagcggcaa attgtcgagg 389101 tgtttaacag cacgaaagcc gaactccctg aaggaatggc tgttcaccaa gtgtttgaag 389161 agcaagcgaa acggacgccg gcgagcaccg ccgtcgtata tgaaggaacc aagctgacgt 389221 accgcgagct gaatgcagcg gctaaccgtc tggcgagaaa gcttgtcgaa catgggcttc 389281 aaaaagggga aacagcagcg attatgaacg accgctcagt agaaaccgtt gtcggcatgc 389341 tggctgtttt aaaagcaggc gccgcatatg tgccgcttga tccagcgctt cctggggatc 389401 gtcttcgttt catggcagag gacagctccg ttcgaatggt tttgatcgga aattcttata 389461 cagggcaggc acatcagctg caagtgccgg ttcttacact ggacataggc tttgaagaga 389521 gtgaagcggc tgacaatctc aacctgccat ccgccccgtc tgatttggcg tacatcatgt 389581 acacatccgg ttcaacgggc aaaccgaaag gcgtcatgat cgaacataaa agcattctgc 389641 gcctcgtcaa aaatgccggg tacgttcctg ttactgaaga agaccgcatg gcgcaaacgg 389701 gagctgtcag ctttgatgcc ggaacgtttg aggtattcgg cgcactgctg aatggcgcag 389761 cactttatcc ggtcaaaaaa gagacactgc ttgatgcgaa acaatttgct gcattcctgc 389821 gtgagcaaag catcacaact atgtggctga catcaccttt attcaaccag cttgctgcaa 389881 aggatgcggg tatgttcggc acactgcgcc atttaatcat cggcggagat gcccttgtcc 389941 cgcatattgt cagcaaagta aaacaggcat cgccgtcgct ttcattgtgg aacggatacg 390001 gcccgacaga aaacacgacg ttttcaacca gttttctgat cgaccgcgag tatggcggct 390061 ctatcccaat cgggaagccg atcggaaatt ccactgccta tattatggat gagcagcaat 390121 gcctgcagcc aatcggcgcg cctggtgagc tttgcgtagg cggaatcggt gtagcgcgtg 390181 ggtatgtcaa tctccctgag ctgacggaga agcaatttct ggaagacccg ttcagaccgg 390241 gtgagagaat ttaccgcact ggtgacttgg caagatggct gccggacggc aatatcgaat 390301 ttttaggcag aatcgacaac caagtgaagg tgcgcggctt ccgaattgag cttggcgaaa 390361 ttgaaacaaa actgaacatg gctgagcatg tgacagaagc cgcggtgatc atacgcaaga 390421 acaaagcaga cgaaaatgaa atttgcgcgt acttcacggc ggatcgtgaa gtggctgtga 390481 gtgagctgag aaaaacactg tctcagtctt tgcctgacta tatggtccct gcccacctga 390541 ttcaaatgga cagcctgccg ctcacgccaa acgggaaaat caacaaaaag gaactgcctg 390601 caccgcaatc agaagccgtg cagccggaat acgcagcacc aaaaacagag agtgaaaaga 390661 aattagcgga gatctgggaa ggaatactcg gcgtcaaagc aggcgttacc gataacttct 390721 ttatgatcgg cggccattct ttgaaagcga tgatgatgac ggcgaaaatt caagagcatt 390781 ttcataagga agttccgata aaagtgcttt ttgaaaagcc gactattcaa gaactggcac 390841 tgtatttgga agagaacgaa agcaaggagg agcagacgtt tgaaccgatc aggcaagcat 390901 cttatcagca gcattatcct gtatccccgg cccagcggag aatgtatatc ctcaatcagc 390961 ttggacaagc aaacacaagc tacaacgtcc ccgctgtact tctgctggag ggagaagtag 391021 ataaagaccg gcttgaaaac gcgattcagc aattaatcaa ccggcacgaa atcctccgta 391081 catcgtttga catgatcgac ggagaggttg tgcaaaccgt tcataaaaac atatcgttcc 391141 agctggaggc tgccaaggga cgggaagaag acgcggaaga gataatcaaa gcatttgttc 391201 agccgtttga attaaaccgc gcgccgctcg tccgttcgaa gcttgtccag ctggaagaaa 391261 aacgccacct gctgctcatt gatatgcatc atattattac tgacggaagt tcaacaggca 391321 ttctaatcgg tgatcttgcc aaaatatatc aaggcgcaga tctggaactg ccacaaattc 391381 actataaaga ttacgcagtt tggcacaaag aacaaactaa ttatcaaaaa gatgaggaat 391441 actggctcga tgtctttaaa ggcgaactgc caatactgga tcttcccgcg gatttcgagc 391501 ggccagctga acggagcttt gcgggagagc gcgtgatgtt tgggcttgat aagcaaatca 391561 cggctcaaat caaatcgctc atggcagaaa cagatacgac aatgtacatg tttttgctgg 391621 cggcgttcaa tgtactcctt tccaagtacg cgtcacagga tgatatcatt gtcggctcgc 391681 cgacagctgg cagaacacat cctgatctgc aaggtgtgcc gggtatgttt gtcaacacgg 391741 tggcactcag aacggcacca gcgggagata aaaccttcgc gcaattcctt gaagaggtca 391801 aaacagccag ccttcaagca ttcgagcacc agagctatcc gcttgaggag ctgattgaaa 391861 agcttccgct tacaagggat acaagcagaa gtccgctgtt cagcgtgatg ttcaacatgc 391921 agaatatgga gattccttca ttaagattag gagatttgaa gatttcctcg tattccatgc 391981 ttcatcatgt tgcgaaattt gatctttcct tggaagcggt cgagcgtgaa gaggatatcg 392041 gcctaagctt tgactatgcg actgccttgt ttaaggacga gacgatccgc cgctggagcc 392101 gccactttgt caatatcatc aaagcggccg cggctaatcc gaacgttcgg ctgtctgatg 392161 tagatctgct ttcatctgca gaaacggctg ctttgctaga agaaagacat atgactcaaa 392221 ttaccgaagc aacctttgca gcactttttg aaaaacaggc ccagcaaaca cctgaccatt 392281 ctgcggtgaa ggctggcgga aatctgttga cctatcgcga gcttgatgaa caggcgaacc 392341 agctggcgca tcatcttcgt gcccaagggg caggaaatga agacatcgtc gcgattgtta 392401 tggaccggtc agctgaagtc atggtatcca ttctcggtgt catgaaggcg ggggcagctt 392461 tccttccgat tgatcctgat acacctgaag aacgaatccg ttattcatta gaggacagcg 392521 gagcaaaatt tgcggtcgtg aatgaaagaa acatgacggc tattgggcaa tatgaaggga 392581 taattgtcag ccttgatgac ggtaaatgga gaaatgaaag caaggagcgc ccatcatcca 392641 tttccgggtc tcgcaatctt gcatacgtca tttatacgtc cggtacgacc ggaaagccaa 392701 agggcgtgca gattgagcat cgtaatctga caaactatgt ctcttggttt agtgaagagg 392761 cgggcctgac ggaaaatgat aagactgtat tgctttcatc ttacgcattt gaccttggct 392821 atacgagcat gttccctgta cttctgggcg ggggcgagct ccatatcgtc cagaaggaaa 392881 cctatacggc gccggatgaa atagcgcact atatcaagga gcatgggatc acttatatca 392941 agctgacacc gtctctgttc catacaatag tgaacaccgc cagttttgca aaagatgcga 393001 actttgaatc cttgcgcttg atcgtcttgg gaggagaaaa aatcatcccg actgatgtta 393061 tcgccttccg taagatgtat ggacataccg aatttatcaa tcactacggc ccgacagaag 393121 caacgatcgg cgccatcgcc gggcgggttg atctgtatga gccggatgca tttgcgaaac 393181 gcccgacaat cggacgcccg attgcgaatg ccggtgcgct tgtcttaaat gaagcattga 393241 agcttgtgcc gcctggagcg agcggacagc tctatatcac gggacagggg ctcgcgagag 393301 ggtatctcaa caggcctcag ctgacagccg agagatttgt agaaaatcca tattcgccgg 393361 gaagcctcat gtacaaaacc ggagatgtcg tacgaagact ttctgacggt acgcttgcat 393421 ttatcggccg ggctgatgat caggtgaaaa tccgaggcta ccgcattgag ccgaaagaaa 393481 ttgaaacggt catgctcagc ctcagcggaa ttcaagaagc ggttgtacta gcggtttccg 393541 agggcggtct tcaagagctt tgcgcgtatt atacgtcgga tcaagatatt gaaaaagcag 393601 agctccggta ccagctttcc ctaacactgc cgtctcatat gattcctgct ttctttgtgc 393661 aggttgacgc gattccgctg acggcaaacg gaaaaaccga cagaaacgct ctgccgaagc 393721 ctaacgcggc acaatccgga ggcaaggcct tggccgcacc ggagacagcg cttgaagaaa 393781 gtttatgccg catttggcag aaaacgcttg gcatagaagc catcggcatt gatgacaatt 393841 ttttcgattt aggcggccat tcattaaaag ggatgatgct gattgccaac attcaggcgg 393901 aattggagaa aagcgtaccg cttaaagcac tgttcgagca gccgacagtt cgccagctgg 393961 cggcttatat ggaggcgtct gctgtttcag gcggccatca agtactcaaa ccggctgaca 394021 agcaggatat gtatccattg tcatccgcac agaaacgaat gtacgtgctc aatcagcttg 394081 accgccagac gataagctac aacatgccat ctgttcttct aatggaagga gagcttgata 394141 tttcgcgcct gcgcgactca ctcaatcagc ttgtgaaccg tcacgaatca ttgcggacgt 394201 catttatgga agctaatggt gagcctgttc agcgcatcat tgagaaggcg gaggttgatc 394261 ttcatgtgtt tgaagccaaa gaagacgaag cggaccaaaa gattaaggaa tttatccggc 394321 cattcgactt aaacgacgca ccgctcattc gcgcagcttt gcttcgaata gaagcgaaaa 394381 aacatttgct gcttttagat atgcatcata tcatcgcaga cggcgtctca agaggcatct 394441 ttgtaaaaga attggcgctg ctttacaaag gagagcagct tccggagccg acgcttcatt 394501 ataaagattt cgccgtttgg caaaatgaag ctgagcaaaa agaacggatg aaggagcatg 394561 aggcgtactg gatgtcagtt ctttcaggcg agctgccaga gcttgatctc ccgctcgatt 394621 atgcccgtcc gcctgtgcaa agctttaaag gagatacgat ccgtttccgt acgggaagtg 394681 agacggcaaa ggcggtagaa aaactgcttg ccgaaaccgg aacgaccttg cacatggtgc 394741 tccatgctgt tttccacgtc tttttaagca aaatttccgg acagcgggat atcgtcatcg 394801 gctccgttac tgccggccgg acgaatgctg atgttcagga catgccggga atgttcgtca 394861 atacacttgc cctgagaatg gaagcgaaag aacagcaaac atttgcggag cttttggagc 394921 tagcaaagca gacgaacctg tcagcccttg agcatcagga gtatccgttt gaagatctgg 394981 ttaatcagct tgatctccct cgggatatga gccgaaaccc attgtttaat gtgatggtga 395041 cgacagaaaa ccctgataaa gaacagctta cattgcaaaa tctgagcatt tcaccttatg 395101 aggctcatca gggaacttct aagtttgatc tgacactggg cggatttact gatgaaaatg 395161 gcattggctt gcagctcgaa tatgcgacag atctgttcgc aaaagaaaca gctgaaaaat 395221 ggagcgaata cgttctgcgg ctactaaagg ctgttgcgga taacccgaac cagccgcttt 395281 ccagtctgtt actggtcacc gagacagaaa agcaagcgct tcttgaggca tggaagggca 395341 aagcgctgcc tgtgccgaca gacaaaacgg ttcatcagct attcgaagag actgtccagc 395401 gccacaaaga ccgcccggct gtcacataca acggccaatc ttggacgtac ggcgagctga 395461 acgcgaaggc aaaccgcctc gcccggattc tgatggactg cggcatcagc ccggatgacc 395521 gcgtcggcgt tctcacgaag ccgtcgcttg aaatgtccgc cgcggtgctc ggcgtcttga 395581 aagccggagc ggcgtttgtg ccgattgatc ctgactaccc ggatcagcgg attgagtata 395641 ttttacagga cagcggcgcg aagcttctct tgaaacagga aggcatttca gtgccggaca 395701 gctatacggg agatgtcatt cttctcgacg gaagccgcac gattctaagc ctgccgcttg 395761 atgaaaacga cgagggaaat ccagaaaccg ctgtaaccgc ggagaacttg gcgtacatga 395821 tttacacgtc tggaacgacc ggacagccga agggtgtcat ggtcgagcac catgcgcttg 395881 tgaacctgtg cttctggcac cacgacgcgt tcagcatgac agcggaggac cgcagtgcga 395941 agtacgcggg cttcgggttc gacgcttcca tttgggagat gttcccgacc tggacgatcg 396001 gcgctgaact tcacgtcatt gatgaagcga tccgcctcga tatcgtccgc ctgaacgatt 396061 attttgaaac gaacggcgta acgatcacgt tcctgccgac acagcttgcg gaacagttca 396121 tggagcttga gaacacatca cttcgcgtcc tcttgaccgg aggagacaag ctgaagcggg 396181 cagtgaaaaa gccgtacaca ctcgtcaaca actacgggcc gacagaaaat acggtcgttg 396241 ccacaagcgc agaaatccat ccggaggaag gctcgctttc catcggacgg gccattgcca 396301 atacgagagt atacattctc ggcgagggca atcaggtgca gccggaaggc gtagccggag 396361 agctttgcgt ggcggggcgc ggactggcac gaggctatct gaatcgagaa gacgaaaccg 396421 cgaagcggtt tgtcgctgat ccgtttgtgc cgggtgaacg catgtaccgc accggcgact 396481 tggtgaagtg ggtgaacggc ggcatcgaat acatcggccg gatcgaccag caggtcaagg 396541 tccgcggcta ccggatcgag ctctcagaaa ttgaagtcca gctcgcccag ctttctgagg 396601 tgcaggatgc ggcggtgaca gctgtcaaag ataaaggcgg caatacagcg atcgcggcgt 396661 atgtcacacc ggaaacagct gacatagaag cactaaaatc aacactaaag gaaaccctgc 396721 cggattacat gatcccggcg ttctgggtga cgctgaacga gcttccggtt acggcaaacg 396781 gcaaagtcga ccgcaaagcc ttgcctgagc cggacatcga agcgggaagc ggagaataca 396841 aagcgccgac gaccgacatg gaagagctgc ttgccggcat ctggcaggac gtgcttggaa 396901 tgtctgaagt cggtgtcacc gacaatttct tctcgcttgg cggagattcc atcaaaggaa 396961 ttcaaatggc gagccgcttg aatcagcacg gctggaagct ggaaatgaaa gatctcttcc 397021 agcatccgac gatcgaagag ctcacccagt acgtagagcg tgccgaaggc aaacaggcag 397081 accaaggccc ggtggagggc gaagtcatcc tgacgccgat ccagcgctgg ttctttgaaa 397141 agaacttcac gaacaagcac cactggaacc aatcggtgat gcttcacgcc aaaaagggct 397201 ttgatcctga acgggtggag aaaacattgc aggcgctgat cgagcatcat gacgcgctcc 397261 gcatggtcta ccgcgaggaa aacggggaca tcgttcaggt gtataaaccg atcggtgaga 397321 gcaaggtcag cttcgaaatc gtggatctgt acggctccga tgaagagatg ctgagaagcc 397381 agattaagct tctcgcgaac aagctgcaaa gcagtctcga tctgcgaaac gggccgcttt 397441 taaaggcgga gcaatatcgc acagaagctg gggatcacct gctcattgct gtacaccatc 397501 tcgtggtcga cggtgtgtca tggcggattt tgcttgaaga ctttgcttca ggctacatgc 397561 aggctgagaa agaagagagc cttgtcttcc cgcaaaaaac aaactccttc aaggattggg 397621 cggaagaact ggcggcattc agccaatcag cgcatctttt acagcaggct gaatactggt 397681 cgcaaattgc cgctgaacag gtttctcctt tacctaagga ttgtgaaaca gagcagcgga 397741 tcgtcaagga tacatcatct gtcctatgtg aattaacggc agaagacact aagcatcttt 397801 taacagatgt tcatcagcca tatggaactg aaatcaacga tattcttctc agcgcgctcg 397861 gtttgacaat gaaagaatgg acaaaggggg ccaaaattgg cattaacctt gagggacacg 397921 gccgggagga cattatcccg aatgtgaata tctccagaac ggtcggctgg tttacggcac 397981 aataccctgt tgtgctcgac atatctgacg cagatgcctc agctgtgatc aaaacagtca 398041 aagaaaacct gcgccgcatt ccggacaaag gtgttggcta cggcattctt cgttatttca 398101 cagaaacagc ggaaacaaag ggcttcacac cggagatcag cttcaactat ttgggccaat 398161 tcgacagtga agtcaaaacc gatttctttg aaccgtccgc tttcgatatg gggcgccaag 398221 taagcggaga atcagaggcg ctgtacgcat taagcttcag cggcatgatc agaaacggcc 398281 ggtttgtgct ttcctgctcc tacaatgaga aggagtttga aagagctaca gtcgaggagc 398341 aaatggaacg gtttaaagaa aacctcctga tgctaatccg ccattgcacg gaaaaagaag 398401 acaaggaatt cacaccaagc gacttcagcg ccgaagacct tgaaatggac gagatgggag 398461 atatctttga catgcttgag gagaatttaa aataaaacgc aagggaatta cagaaggcgg 398521 gagcgaaaca tatgagtcaa tttagcaagg atcaggttca agatatgtat tacctatcgc 398581 cgatgcagga agggatgctt tttcatgcca tcctgaatcc cggccaaagc ttttaccttg 398641 aacaaatcac gatgaaagta aaaggcagct tgaatatcaa atgtcttgaa gaaagcatga 398701 atgtgatcat ggaccggtac gatgtatttc gtaccgtgtt cattcacgaa aaagtaaaaa 398761 ggcctgtcca agtcgtattg aaaaaacggc agttccatat agaagaaatc gatctgacac 398821 acttaacggg cagcgagcaa acagccaaaa tcaatgagta caaagaacag gataagatca 398881 ggggttttga tttgacgcgg gatattccga tgcgggcagc cattttcaag aaagctgaag 398941 aaagctttga atgggtgtgg agctaccacc acattatttt ggacggatgg tgcttcggca 399001 tcgtcgtaca ggatctattt aaggtataca atgctctgcg cgaacaaaag ccgtacagcc 399061 tgccgcccgt caaaccgtat aaagactaca tcaagtggct tgaaaagcag gataaacaag 399121 catcactgcg ttactggcgc gaatatttag agggctttga aggacaaacg acgtttgcgg 399181 agcaaagaaa gaaacaaaag gacggctatg agccgaaaga gctgctcttt tcactgtcgg 399241 aggcggaaac aaaggccttt accgagcttg caaaatcgca gcataccact ttgagtacgg 399301 cgctgcaggc agtctggagc gtattgatca gccgctatca gcagtctggc gatttggcct 399361 tcggtacagt tgtttcaggg cgtcccgcgg aaatcaaagg cgttgaacat atggtcgggc 399421 tgtttatcaa cgttgtcccg agacgtgtga agctgtctga gggtatcaca tttaacggct 399481 tgctcaagcg gctgcaggag caatcgctgc agtccgagcc gcatcaatat gtgccgcttt 399541 atgacatcca aagccaggcc gatcagccga aactgattga ccacatcatt gtttttgaga 399601 actatccgct tcaggatgcg aaaaatgaag aaagcagtga aaacggcttt gatatggtgg 399661 atgttcatgt ttttgagaag tcgaattatg atctcaacct gatggcttcc ccgggagatg 399721 agatgctgat taagcttgcc tataatgaga atgtgtttga tgaggcgttt atcctgcgct 399781 tgaaatctca gcttcttaca gcaattcagc agctcatcca gaatcctgat cagcctgtca 399841 gcacgatcaa cctcgttgac gacagggaga gagaattttt gctaaccggc ttaaacccgc 399901 cggctcaagc tcatgaaaca aagcctctga cgtattggtt caaggaagca gtgaacgcca 399961 atccggatgc accggcgctt acgtattccg gccagaccct gtcttatcgc gaattagatg 400021 aggaagcgaa ccgcattgca cgccggctgc aaaaacacgg tgcgggcaaa ggctctgttg 400081 tagcgctgta cacgaagcgc tcacttgaac tggtgatcgg cattctcggt gtattaaagg 400141 cgggagcagc ctatctgccg gttgatccga agctgccaga ggaccgaatc tcgtatatgc 400201 tggctgacag tgcggcagcc tgtcttctga cgcatcagga gatgaaagaa caagcggctg 400261 agctgccgta tacaggcaca acgctcttca ttgatgatca aacacggttt gaagaacagg 400321 caagcgatcc tgcaaccgcg attgatccta atgatccggc atatatcatg tacacgtccg 400381 gcacaaccgg aaagccaaag ggcaatatca ccactcatgc caatattcaa ggattggtca 400441 agcatgtaga ctacatggca ttttctgatc aggatacgtt cttgtctgtt tcgaattacg 400501 cctttgatgc atttaccttt gatttctatg cttctatgct gaatgcggca cggctcatta 400561 tcgcagatga acatacgctg cttgatacag aacggctcac agatctgatc ctgcaagaga 400621 atgtcaatgt catgtttgcg acaaccgcac tatttaatct tctcacagat gcgggagagg 400681 attggatgaa ggggcttcgc tgtatattat tcggcggaga gcgcgcgtca gtgcctcatg 400741 tcagaaaagc gctgcggatc atggggccgg gcaagctgat taactgctac gggccgactg 400801 agggaacagt gtttgcgaca gctcacgtcg tgcatgatct gccggattcc atctcctcat 400861 tgccgatcgg aaagccgatc agcaatgcca gtgtttatat tctgaatgag caaagccagc 400921 tccagccatt cggggcggtc ggtgaactgt gcatcagcgg aatgggcgtg tcaaaagggt 400981 atgtaaatcg tgctgacctc acgaaggaaa agtttatcga gaacccgttc aagccgggag 401041 aaacgcttta ccgtacaggg gatttagcgc gctggctgcc ggatggaacg attgaatacg 401101 ccggccgtat tgacgaccag gtcaaaatac gcggacaccg gattgagctt gaagaaatcg 401161 aaaagcagct gcaggaatac ccaggtgtga aagatgcggt cgttgtggcg gaccgccatg 401221 agtctggcga tgcatcaatc aatgcctacc ttgtgaaccg aacgcagctt tcagctgaag 401281 acgtgaaggc gcacctgaaa aaacagcttc ctgcttacat ggtgccgcaa acctttacct 401341 tcttggatga gcttccttta acgacgaacg ggaaagtcaa taaacggctg ctcccaaaac 401401 ctgatcagga tcagctggcg gaagaatgga ttggaccgcg gaacgagatg gaagaaacaa 401461 tcgcacaaat atggtctgag gttctcggca gaaagcaaat tggcattcat gacgatttct 401521 ttgcgctcgg agggcattcc ttgaaggcca tgaccgccgc gtcccgcatc aagaaagagc 401581 tcgggattga tcttccagtg aagcttttgt ttgaagcgcc gacgatcgcc ggcatttcag 401641 cgtatttgaa aaacgggggc tctgatggct tgcaggatgt aacgataatg aatcaggatc 401701 aggagcagat cattttcgca tttccgccgg ttctgggcta tggccttatg taccaaaatc 401761 tgtccagccg cttgccgtca tacaagctat gcgcctttga ttttattgag gaggaagacc 401821 ggcttgaccg ctatgcggat ttgatccaga agctgcagcc ggaagggcct ttaacattgt 401881 ttggatattc agcgggatgc agcctggcgt ttgaagctgc gaaaaagctt gaggaacaag 401941 gccgtattgt tcagcggatc atcatggtgg attcctataa aaaacaaggt gtcagtgatc 402001 tggacggacg cacggttgaa agtgatgtcg aagcgttgat gaatgtcaat cgggacaatg 402061 aagcgctcaa cagcgaagcc gtcaaacacg gcctcaagca aaaaacacat gccttttact 402121 catactacgt caacctgatc agcacaggcc aggtgaaagc agatattgat ctgttgactt 402181 ccggcgctga ttttgacatg ccggaatggc ttgcatcatg ggaagaagct acaacaggtg 402241 tttaccgtgt gaaaagaggc ttcggaacac acgcagaaat gctgcagggc gaaacgctag 402301 ataggaatgc ggagattttg ctcgaatttc ttaatacaca aaccgtaacg gtttcataaa 402361 tgaagtgatg aaaggaggag acagccaatg agccaactct tcaaatcatt tgatgcgtcg 402421 gaaaaaacac agctcatctg ttttccgttt gccggcggct attcggcgtc gtttcgccct 402481 ctccatgctt ttttgcaggg ggagtgcgag atgctcgctg ccgagccgcc gggacacggc 402541 acgaatcaaa cgtcagccat tgaggatctc gaagagctga cggatttgta caagcaagaa 402601 ctgaaccttc gccctgatcg gccgtttgtg ctgttcggac acagtatggg cggaatgatc 402661 accttcaggc tggcgcaaaa gcttgagcgt gaaggcatct ttccgcaggc ggttatcatt 402721 tctgcaatcc agccgcctca tattcagcgg aagaaagtgt cccacctgcc tgatgatcag 402781 tttctcgatc atattatcca attaggcgga atgcccgcag agcttgttga aaataaggag 402841 gtcatgtcct ttttcctgcc ttctttccga tcagattacc gggctcttga acaatttgag 402901 ctttacgatc tggcccagat ccagtcgcct gttcatgtct ttaacgggct tgatgataaa 402961 aaatgcatac gagatgcgga agggtggaag aagtgggcaa aagacatcac attccatcaa 403021 tttgacggcg ggcacatgtt cctgctgtca caaacggaag aagtcgcaga acggattttt 403081 gcgatcttga atcagcatcc gatcattcaa ccgtgatcaa aagcggacag cttcggctgt 403141 tccgcttttt ttgtgttgaa tgccaatttc tgcatggtat aatagtcgaa atactcaaat 403201 aaaggcaggt cgaaacatgc gcacgtctcc caggatgaaa tggtttgtat tgctgtttac 403261 gtttgttttc gccatcggaa tgaactcatt cagaaattcc tttcaatttt ttatgctgcc 403321 aatggcagac gccttccatg ccgacaggtc gctgatttcg gtttctgtca gcatttttat 403381 gatcacaacc ggcatcgtcc agttttttgt cggttttttt atcgaccgtt tcagtgtcag 403441 aaaaattatg gcgctgggag ctgtttgcat cagcgcaagc tttttggtgc ttccttattc 403501 accgaatgtt catgtgtttt ccgccattta cggtgtgctt ggcggaatcg ggtattcctg 403561 cgcggtcggc gtgacgaccc agtatttcat cagctgttgg tttgacacac acaaaggtct 403621 ggcgcttgct attttgacca atgccaactc tgcgggcctg ctgcttctct cgcccatttg 403681 ggctgcggct ccgtatcatg ccggctggca gagcacctat accattttgg gaatcgtcat 403741 ggcggctgtt ctgctgccgc tcctcgtctt tgggatgaag cacccgccac atgcgcaagc 403801 ggaaactgtg aaaaaatctt atgattggcg agggttttgg aacgtgatga agcaatcccg 403861 cctcattcat atcctgtact tcggcgtgtt tacttgcgga tttacaatgg gaattattga 403921 tgctcacctc gtcccgatac tgaaggatgc gcatgtctct catgtcaacg gaatgatggc 403981 cgcgttcggg gcatttatca tcattggcgg attattggcg ggctggctgt cagatctcct 404041 cggcagcaga agcgtcatgc tatccatctt atttttcatt cggctgctca gcctcatttg 404101 cctgctcatt cccattctcg gaattcatca cagcgacctt tggtacttcg ggtttatcct 404161 gttattcggg ctcagttaca caggcgtgat cccgctgacc gcggcgtcaa tttcggaaag 404221 ctatcaaaca ggattgatcg gatcgctgtt aggcatcaat ttctttatcc atcaggttgc 404281 cggagctctc agcgtgtatg cgggcggttt gttttttgac atgactcatg gttatttact 404341 gattgtcgct gtgtgcatcg tgtttgtggg tttatcggct gtaatagagc tggtgccgtt 404401 tttagataaa cagaaggcaa aagaaaccca ccattcaata taaaaggatc agcactgtca 404461 atgctgatcc tttttaaatt tgagtttttt tgtttcggta tttttaagga taatctcctt 404521 gaatctgttc atctcctctt cggagtgaaa aaaatgtttg gggatcgcaa tatattggcc 404581 acttgatgta ttgaccctga agatattttt atattcgaaa acagctgtaa tttcatccca 404641 attgaaaatg aggtcatatt ttttagaaca tatacgaatt ccttcttggt tcagagtata 404701 tgttcttttg gatttcatcc gttcgttctt cttgtatgct ctggaaaact tcacatatag 404761 aagaaggagg agcagcagtg taaacagaac ggacatcacg ataatcaaca tactgttcat 404821 aaacaagtta agcgcgtcac ttccataaac gatacggggc catccgttaa tgaagttaac 404881 tgcagcaaat atggcgcaaa acaatagaaa gtaaaagcat gatatttttg cgatttgata 404941 aaaaaagatt tctcttacat ccttaaaagt gatttctcct ggaagattga tactttcact 405001 agcatattga atcatacggt aaacctacac ctctaaccat gtttttcctt ttagtctagc 405061 ataatttctc atttttttgc aggcatacca gggcgctttg tttttttctc cagattgata 405121 ttgctcccca ccacgccaat cataatacaa acagccccgg caagatgata ccaggccagg 405181 ctttcgttga gaatcacaaa tcctgcaatc atcgtcacaa tggtagatac atgattaaaa 405241 gcgctcattt taaacgcctc aattcgcgac agcgtatagt tagacagaaa tgaagtgaca 405301 agtgaagaca gcacgcccaa atacacaatg gcgagaacga agccgggctc ccggaacggc 405361 agaaaataag tgccgactgt tcccgccgct ccgtgacgca caagggcgat ggcgttgaag 405421 acgacaaagc cgatggctga catgatgtag gtgagctcgg tcagcttgaa ccgctgcgtc 405481 atttttctgg cagcagtatt gtacatcgct gaagacaaag cggacaatag gatcagcaaa 405541 gaccctttta agctggctga ttccacgtca acgcctttca tcacaaaaat aaacatgacg 405601 ccggcaacgg ataaaaccgt gaaccccttt tgcgtccacg ttgggcgttc ctttaaaaca 405661 taagcggcaa agaccatcgt gaaaatcgga atggctgcct gaataattcc cgcttcagag 405721 gaggacgagt acacaaggcc gaatgcctga aagctgaaaa ataacgcggg atacagcagg 405781 gcgagcggca aaatgtcaat gacgtccttt acgcggattg atagctttac ccagccgaat 405841 aagatcggta cagtggccgc agcaaacgca atggtgaacc gatgcgccaa aatatcaaac 405901 ggctctgctg tttgcagtgc gatttttacg aatagaaagg ataaaccgat aatgaacgaa 405961 tataaaatag ccgctatata agcgggggtt tgctgatgtt taaccataat gggaagggct 406021 cctttacctg aattgcagcg ccggtcgctc cctttattgt atggccgcgg tcagaacggt 406081 acaatgagaa aaacaatgaa ctgtaccggt acaaaacagg gggagaaggc atggagaaat 406141 atatgagtct attaacgagg atagaggaga tgatgcaaag cacctcatat caagaaggag 406201 acaggcttcc atctatccgt cagctgtccg cccgctacca agtcagcaaa agcacagtga 406261 tccgcgcgct gcaggagctg gaaaagcgcc accttatcta ttctgttccg aaaagcggct 406321 attatattgt gaaaaagtca gggaaatcaa aaagcgggca gcctggcccc atcgactttg 406381 ccacatctgc gccggatccc gatgtgtttc cgtatcttga ttttcagcac tgcatcaaca 406441 aagcgattga tacatacaaa aacgatttgt ttatttatgg gacgccaaag gggcttccat 406501 cactcatccg cgtactccga aagctcttgg ccactcaaca ggtatttgcg gatgaacggc 406561 atattttcat tacatcaggt gtccagcagg cgttatcctt gctttgtgcc atgccgttcc 406621 caaatgggaa agagaagatc gccattgaac agccgggcta ccatttgatg gtcgaacagc 406681 ttgagacact tgggattccc gccatcgggg tgaaacgaac ggaagaaggg cttgatatag 406741 ccaaggttga gcggttattt caaacagaat cgattaaatt tttttatacg atgccgcgct 406801 tccataaccc gcttgggtgc tcattgtcag agcgtgataa acaggagctt gtgagactgg 406861 cagaagcgta tgatgtctat ctcgttgagg atgattacct cggtgatctg gaggaaaata 406921 aaaaggcaga tccgctgtac gcatatgatc tgtcctcaca tgtcatctat ttgaaaagct 406981 tctcgaaaat gatgttcccc ggcctccgcg tgggggcggc tgttttgccc gaagcgctga 407041 ctgacacgtt ctatgcgtac aaaaagctga acgacatcga ctgttcgatg atttctcaag 407101 cggcattgga gatttacctg aaaagcggta tgtacggcag gcataaggag aaaatcagag 407161 attcttataa agagcggtcg ctgaggctac atcaagccat tcgaactcac aggcagctgg 407221 gaagcggacg ctttacgttc tccagcgggc aggcaccctg tatgcacacc catctggtgc 407281 ttcctcagga tctgcccgcc tcaagagtga ttcatagact ggaaaaacaa ggggttctcc 407341 ttgaggcgat agaccgtcat tatttatcag attatccgaa agaaaatcta ttaaaaatca 407401 atatttccaa tgtgaaaacg gaagatattg agcgcggtgt caagctgttg atgagccatt 407461 tataaaagct cttcgtacga gaccattgtg atatcctcgg ggaaatcagg gtgtacggcg 407521 catacagcca ttttgtagcc gggatcgacc tcatacgttt tgatatagca tggggaatgg 407581 ctgtccggaa gctcaatgga tacttgtccg tcctggtgca ggcgcactga aaaggaatca 407641 agcggaagcg ataagccttt gccttccttg tttgataaag ctttctttca ttgaccatag 407701 atgataaaaa tagtctgtct gctcgtcctt gtcttttgct aaaaggtcgc tgtactctgt 407761 ttttgaaaag aagcgcttgg cgatctcaag gctgatcggt ttcgtttttt cgatatctat 407821 gccgatcggc tgtgaatcaa acgcgcaaat gacccagcgt ccggagtgag aaatgttgaa 407881 atgagcgtcg ggaagatcag ggatgcacgg cttcccgtat tcctgcgtgc taaagcggat 407941 atcggatttg tccaactgat actgcctgct tatgactgag cgaacgagca catctcccag 408001 cagggtgcgg tgagcatctt ctttatgata aaatctccgg catttctccc gtttttcagg 408061 tgatatgaaa gacatgaacc gttcattttc ttcctgtgaa agcgggcggt ccatataaat 408121 tccgtaaatc ttcattctag atcctccgtc tgcaaaagat tgtcaaaacc atcctatcat 408181 acttccacaa gactcatata gaggagaaaa taaaaaaaca aagccaaggc ggctttgttt 408241 tagtgtacag gcggagatgc tttcactgcg gctgtccgcc ttgccacagc ataattcagc 408301 aactggattg actggggcaa tgaaaaacgc aaaataagtc cggtgaggat ggcggtcaaa 408361 atggtgccaa aaccgatcgg tccgcccatg ccccatgccg caaacaaaat ggttaattcc 408421 atgccgttcc gcacccattg cacattccag ccggtttttt ctgtaatcag catcatcagt 408481 gaatcacgcg gccccgcgcc aaggcctgct gatacataaa caccgacgcc gtaaccaatc 408541 agcaccacgc ctagagagaa gacgatgatc gagcctgtgt aggtcgagag ggcaggcaga 408601 atgaaattga aaaaatctat aaatacacca atgagcacca tattcaggag ggcaccaatt 408661 ttcggccaag ctctcgtaaa caatgacgtg aatccgacga tgagcgctcc aataatgatg 408721 gaccactggc cgacggtaag cccgaagtgc tgaaacaggc tgtaatgaaa tgcatcccac 408781 ggactaatgc cgagtgcttt tccttctatc gtcagggata caccaaaagc caaaatgatc 408841 aaaccggcaa aataaaatgt ccagcgcaga acaagttctt gcttcacgtg aggtcccttc 408901 tttcgtaaaa atcagtcgat tgtcattgta gcacatctga cagaagggcg gaataggcga 408961 aaggggctca acaaaaaaac agggccgccg gaggcgccct gtttcagcgt gttggcaaac 409021 ccttgcattc gttgtcaggc ctgtgcttcg gtgctcacga atttaacatt agctgtgctc 409081 caatgctcgc ccttcctaga cttcaaaggt tttcaatcac gctgaaaatc acaaaatcct 409141 aaaacgaata tcgttttagg attttgtcaa taatctgaaa cagggcgctg acgctctgtt 409201 tttcttatta cagcgggttc aaaatccggt ttaagaaccg ctgtgtccgt tcttcttttg 409261 gtgcggagaa aatttgctcc ggcggtccct gctccacgat aacgccgccg tcgatgaaga 409321 tgacttcatc cgcaacctcc tgcgcgaact tgatttcgtg ggtcacgacg accatggtcc 409381 agccttcatt ggccaagtcc ttgataacct tcagcacctc tccgacaagc tcgggatcaa 409441 gcgctgaggt cggttcgtca aacagcatga gctcaggctg tatcgccagt gcgcgggcga 409501 tgccgacgcg ctgctgctgg ccgccggaaa gctggaacgg atataaatcc attttgtcct 409561 tcaatccgac tttatcaaga agctgaatcg cttcttttct gacttcctct ttgttccgtt 409621 tttgcacctg aacagggccc tccatcacgt tttcgagggc tgtgcggtgc gggaacaggt 409681 gatacgcctg aaacaccatt ccggattttc ggcgaagctt taggatatcc gcctgtttca 409741 cctttttgga gaaatcgatg gagaaatcat caaatgcaag ctctccgcga ttcgggatct 409801 ccagagcgtt caggcagcgg agcagcgtcg ttttccctga acctgaaggc ccaagtatgg 409861 cgatgacttt tcctttttca atcttcatat ctatcttttt taaaatttca ttttcaccga 409921 atgatttgtt taatccttta acggtaagca tactcggaac ctccttattt ggccacgtag 409981 cggtcaagac gccgttcgat gacatgctgg acgagtgaga gcaggaagca gataatccaa 410041 taaataaagg ctgcttcaat atagatcact aaaatttgat caagattccg cgcgccgatt 410101 tcctgggctt ttctgaacag ctcagcgacc agaatttgag aggcgaggga tgtatcttta 410161 atcaggctga taaaggtatt ggataatggc gggatcgaca cacgaaacgc ctgcggcaaa 410221 atgacgcgga acagcgtttt ttgatgtgtc atgccaattg tgtagccggc ttcccattgc 410281 cctttcggca cggataaaat agatgcccga atgatttcag atgcataggc gccgacgttt 410341 aatgaaaagg cgataactgc gcttggaaat ggatctaatg tgacgttaaa ggccgggaac 410401 agatagaaaa tgatgaacaa ttgaacgaga agaggagtgc cgcgtattgc ggatacgtat 410461 acgctgaaca cccatctcaa aggtctcact ttcgacattc tggcaagcgc cgtaatcagc 410521 gccaggatca ttccgaatat aaaggaaaga atcgtaaggg gaatcgtata gtagattccc 410581 cctgaaagta tcggccagaa tgactgctgc accagatccc acgggatcgc cgtgccaagc 410641 gtcaatgccg gcagattatt tagaaacatc ttcgccgaac cattttttag aaattttaga 410701 aagagtcccg tcctctttca tttcttttaa tgctttgttg acttgatcaa caacctcgcc 410761 gcttccttta cggaacgtga aatatgttga ctgaggctca cctgtttcaa acgcgatttt 410821 cacgttttta ttgccagatg tttttaagta gttcaatacg gcaagcttat cgttgtatgt 410881 catatcgacg cggccttgct ggatcatttg aagggcctgc gccatgcctt caacgccttc 410941 tactttagcg ccggcatttg tagctaattt gttgtagttg cttgtcagtg attgagctga 411001 cgtttttcct tttacatctg cttcagactt aatatcgttg ttgtcttttt tcgttacgac 411061 aacggctctt gatgttgtgt atttatctga gaaatcatat ttgtcttcac gatctgtttt 411121 tccgacttgg ttggcaacaa cgtcaaaccg tttggaattc aggccggcaa acatactgtc 411181 ccattgtgtt tccttaaagt cgactttaag cccgaggcgt tttgcgactt ctgtgataac 411241 ttcgacatca tagccagtca gtttatcagt gtctttgtcg tggtaagtga acggctcata 411301 tgttccttcc gttccgactg tgagcacacc ttttttctta attgaagccc aaagatcgcc 411361 atctttggca ttatcttttg actgattgtc atttcctgct ccgcaagctg caagagctgc 411421 aatacttacg accatgaata aagccaataa tgcttttttc atcttattcc ccacttttct 411481 ggttgatttt attgaaataa aaaattagct tacaaatcta aaggataact tttttttagt 411541 atgagtcaag tatttggttt tcataagaca aaatctttta aaataaatcc aaaaattgct 411601 gtgccggttt aggcaaataa ctgtccgttc tccacatgac agccggtgtc ataatgaagg 411661 gattattttc gatatggacg gtgtgaacgt gatttctcat atgaacggga atcattgtga 411721 caggcaaaat agacgcgccg aatccggatg acacgaggct gagcaaagtt gcagagtcgt 411781 ggcattcaca aacaatgcgc ggctccaggt tcaaacgatg aaattcattc atgacctgat 411841 tatagacgcc ttttccgttg acaggccgca gcaggatcag cggaaatgaa ggaatgtcca 411901 ccatcttaat ggtgtctccg cacggatatc cggcttcatc tgaaagcacg agcacacatg 411961 gaatgtcatc aagctgcttg aattgtactg tgtcactttt gatcagtgtt gtcgtgaccg 412021 ccgcatcgat ttgccggctt tccagcagtt ccaacagtgt cgcgggttca ttttcccaaa 412081 tattaaaggt gagatggggg tatctctctt tgatctgtgt tactttttca agcatcagag 412141 ccgcgcaata aatcgttgat cccacggcaa gtgtaccggc tacttcctcc ttcagctcct 412201 gtacctcaat gactgcatct tcaaacctat gcagaatctc ttttgctctt tttagaaaaa 412261 cagctccttc atatgtaaga gtcatttgtt ttttcttgtt acggtcaaac agaacaacac 412321 caagttcgtc ctccagctgt ttgagctgcc tgcttaaagg cggctgcgcc atgtgaagct 412381 ttttggctgc ggacgtaatt ttctgttctt gggcaatggt aatgaagtat cgaagctggc 412441 gaatatccaa aagaaagcgc ctccttatca taccttttag gtattaatta tagatttaat 412501 agatattttt catatggata tatcaggagt atgattgaaa tgaaagcaga attcaagcgt 412561 aaaggagggg gcaaagtgaa actcgttgtc ggaatgacag gggcaacagg ggccattttc 412621 ggggtcaggc tgctgcagtg gctgaaggcc gccggagtgg aaacccatct cgttgtgtct 412681 ccttgggcaa acgtcacgat caaacacgaa acaggctata cgttacaaga agtagaacaa 412741 ctggccacat acacttactc acataaggat caggcggcag ccatttcaag cgggtcgttt 412801 gataccgatg gaatgattgt tgcgccgtgc agcatgaaat ctctcgcaag cattcgcaca 412861 ggaatggcgg ataatctgct gacacgtgcg gcggatgtca tgctcaagga gagaaaaaaa 412921 ctcgtcctct taacgagaga gacgcctttg aaccaaattc atctcgaaaa tatgctagcg 412981 cttacgaaaa tgggcaccat cattcttcct ccgatgccgg cattttataa tcggccgaga 413041 agcttagagg aaatggttga ccatattgtt tttagaacgt tggaccaatt cggcattcgg 413101 cttcctgaag cgaagcgctg gaatgggatt gaaaaacaaa aaggaggagc ttgatcatgg 413161 cttatcaaga tttcagagaa tttctcgctg cccttgaaaa agaaggacag ctgcttacag 413221 tgaatgaaga ggtaaagccg gaaccggatt taggggcctc cgcacgggca gccagcaatc 413281 ttggcgataa aagccctgcg ctcttattta acaacattta cggctatcat aacgcgcgaa 413341 ttgcgatgaa tgtcatcggc tcttggccaa accatgccat gatgctgggc atgccgaaag 413401 acacaccggt aaaagaacag ttttttgaat tcgcaaagcg ttatgaccag tttccgatgc 413461 cggtcaaacg tgaggaaaca gcgccatttc atgaaaatga aatcacagaa gatatcaatt 413521 tgttcgatat actgcctctt ttcagaatta accagggtga tggaggctac tatttagaca 413581 aagcatgtgt catttcccgt gatcttgagg accctgacaa cttcggcaaa caaaatgtcg 413641 gcatttacag aatgcaagtc aaaggaaaag accgccttgg cattcagcct gtcccgcagc 413701 acgatattgc aatccatctg cgccaagctg aagaacgcgg catcaacctt ccggtcacta 413761 ttgcgctcgg ctgtgagccg gtcattacaa cggcggcatc gactccgctt ctctatgatc 413821 aatcagaata cgaaatggca ggtgcgattc aaggcgaacc atatcgcatc gtcaaatcaa 413881 agctgtctga tcttgatgtt ccgtggggcg ctgaagtggt gcttgaaggt gagattattg 413941 ccggagagcg cgaatatgaa gggccgttcg gtgaattcac aggccattat tccggcggac 414001 gcagcatgcc gattatcaaa attaaacgcg tctatcacag aaacaatccg atctttgaac 414061 atttatactt aggcatgcct tggacagaat gcgattacat gatcggcatt aacacatgcg 414121 tgccgcttta tcagcagtta aaagaagcgt atccgaacga aattgtggca gtgaacgcca 414181 tgtacacaca cggtttaatc gcgattgttt ccacaaaaac ccgctatggc ggatttgcga 414241 aagcggtcgg catgcgcgca ctcacaacgc cgcacggact cggctactgc aaaatggtca 414301 tagtcgttga tgaggatgtc gatccattca accttccgca ggtcatgtgg gcgctttcga 414361 ccaaaatgca tccgaaacat gatgcggtca tcattccgga cttatctgtc ctgccgcttg 414421 atccgggatc caatccatca ggaatcactc acaaaatgat tctcgacgcc actacaccgg 414481 ttgcgccgga aacaagaggc cattattcac agccgcttga ttctccgcta acaacgaaag 414541 aatgggaaca aaaactaatg gacttaatga ataaataagg aaaggatgtt cgaaatgcat 414601 acatgtcctc gatgcgactc aaaaaaggga gaagtcatga gcaaatcgcc tgtagaaggc 414661 gcatgggaag tttatcagtg ccaaacatgc ttttttacat ggagatcctg tgaaccggaa 414721 agcattacaa atcccgaaaa atacaatcca gcgtttaaaa ttgatccaaa ggaaacagaa 414781 acagcaattg aagttccggc ggtgccggaa cgaaaggctt gatccgcgtg aactgtatgt 414841 cagaccgtct ctttgagctg cttgacggga gctgcctgaa tgagaagcag catgaggcct 414901 tcgttctgca aacagtatca gaggatggct ggccgcatgc cgctatgatc agtgcaggtg 414961 aaatcatcgc gctgagccga actgatatcc gaatcgctct gtggaaaaac acaatgactt 415021 cggccaacat ccttcgcaca ggaaaagcac agttcacggc gtggtggaag ggagcggcct 415081 attatgtaaa gcttgaatgc gcgcctttac cgcctttgaa agatgccgaa tatgaaagag 415141 accgtttttc ctgccgcatc gtttcagtga aagaggacgt tgcgaaatac gctgatttga 415201 cttcaggtgt ccgtatacag cttcacagcc ctgaagaggt gctgagcaga tggaaaaaga 415261 ccctggaaga tttaaaacgg taatatcgat agcctgacgc catgcgtcag gcttttttta 415321 tataatgaaa acaaaagggg gcgtgagaaa tggaacgtgc ggggatctgt cactcggacg 415381 gctttgattt agcttatcga attgagggcg agggcgcacc catccttgtg atcgggagtg 415441 cggtttacta tccgcgcctt ttttcctcag atatcaaaca gaaatatcaa tgggtctttg 415501 tcgaccatag gggatttgct aagcctaagc gggagcttcg tgcggaggat tcgaggcttg 415561 atgctgtctt ggctgatatc gaaaggatga gaacatttct tcagcttgag gatgttacta 415621 tcctgggaca ttccgggcac gcttttatgg ctttagagta tgccaggaca tatcccaaac 415681 aagttcggaa ggtggcgctc tttaatactg cgcctgataa cagtgaagaa agacagcgaa 415741 aaagcgaatc atttttcatg gaaacagcca gtcttgagag aaagaaacgc tttgaaaaag 415801 acatcgagaa tttgccgcag gacatcgaca aagatcctga aaggcgcttt gtgcacatgt 415861 gtattcgcgc tgaagcgaaa agcttttatc aagagcggcc gcatgctgct gccttatggg 415921 acggtgtatt cacgaatatg ccgatcattg atgaattatg gggcaataca tttgcccgga 415981 ttgatcttct tcagcggtta gctgatgttc gtatgccggt gtatatcgga ttagggagat 416041 atgattattt ggttgcgccc gtttcgctat gggatgctgt tgacggttta tatccccatg 416101 ttgataaggt tatttttgaa aagagcggcc atcagccgat gctggaagaa ccggaagcct 416161 ttgatcaaag cttcaggaaa tggcttgatc aataaaaaac agcccgcaga tcaacatccg 416221 cgggctgttt ctgattataa gacccctttc atcgcgcgtt tgatcaccgg cgagagcagc 416281 aggagaatgc cgccaagaac gatagaaatc aaaccgatgg tgccgaagta cattgtttca 416341 ggaattttat caaacaatcc ggctacttgg gcattgatcg cttgggctgc tgcgttcgtc 416401 agaaaccaca tactcattgt ctgtgcagag aaggcagctg gtgccagttt cgttgtcacg 416461 gataaaccga ctggagacag gcacagctct ccaagcacga caagcaggaa gctgagaacg 416521 agccaaagcg ggcttacgag tgcttctttt ccttgcatag cagggaatac cataatgata 416581 aatgacaatc cggctaaaat aattccgatt gagaatttaa ctggtgtaga cggctgacgt 416641 ttgccaagct tcatccagag ccatgcgaat attggcgcaa aaatgacaac aaacaatgga 416701 tttaatgatt ggaaccatga tgactgaagt tcgaatccgc ccaatgaaag tcttatgcgt 416761 tcatcagcgt ataccgcaag aatggtcgct ccctgttcct gaatggccca gaacatgaca 416821 gcaccgataa acaaaggaac gtaagcggca agacgggatt tttctgtttt gtccgctttt 416881 ttgcttgtaa acatgatgat gaaataaatc acaggaatca aaataccgag aatacttaca 416941 aggtcaatga aacgtttgat cgtcagcacg cctgtttgta cagagataat cactgcgatc 417001 gccacaatga taacaccgat tccggtgcca attgcagatt ttttagacag cggattcggc 417061 acattggaac ctgcaagccc gaggtttttc tttcttgtca aagcaaatac gataagtccg 417121 agaagcattc cgaccgcggc agctccgaat ccgagatgat agttgtactt ctgtccgagt 417181 gttccgacaa ttaacggcgc gagtaaacca ccgaggttaa tccccatgta gaaaatactg 417241 aaacctgagt cgcggcgcgg gtcttctttc gtgtaaagat ccccaactac gcttgaaacg 417301 tttggtttta ataagcctgt tccgacaatg ataagcacca tactgatata gaatgctatc 417361 gaactgcccg gataggcgag tgcaatgtgg ccgaacataa tgaatatgcc gccgtaaaac 417421 acggtgtttg cggtaccgaa tacccggtca gcgagccatc cgccaataat ggtggacatg 417481 tatacgagtg atccgtaaat cgacataatg gcaaccgcag tgcccttgtc aaagccgagc 417541 cctccgttta ccgtctctgt atacaaatag taaagtaaga ttgctctcat tccatagtaa 417601 gagaaacgct cccaaaattc ggtgaaaaat agtgtaaata gtcctcgcgg gtgaccaaag 417661 aacccttttt gcgggacgct tttaatgata ctttcgttat caatcgaagc catgtcagcc 417721 aaaccctttc taaaaaaagt gtattataaa aatcatattc ttatataata cttgtgtcaa 417781 tataatttat actcatttca aatagttcca tattggaaaa attataaata cctaaaaata 417841 gtgatttcct cctaattttt aaacttttta tcgtgagatt ttcttacaca actattcctt 417901 tatatttttt taataaaatt ttagagaaat gtacaagcag atcgggcctt tgtgagtaac 417961 atgatagtaa tcatagagaa ggaggctcgc aattggctga attcatatta aatgcagcgg 418021 atttcggtgt tcctagagat ggtaaaacgg attcgacaga acggattaat cagtgcctca 418081 gtacagctgt ttcgaaaggc tatcatactg tctggtttcc aaagggaaca tatttaatag 418141 acgcaacgct tggcggagat cttaatcaga ggtttcgaaa cgcggggatc attgttcccg 418201 gcaaccttga gattatgatg gaccccgaat gtatcatgaa agtgataccg aatagttcgt 418261 ggggttattc cgcattttat gtaggcaagc aagagaatat aactatttcc ggaggacaaa 418321 ttatcggcga acgggatgag catacgtatg cctcggcggg gataaggtca acccatgaat 418381 ggggctttgg catatgtatt gaaggatgct cgaatgttgt cattgatgat gtgaaaattt 418441 ccgattttac cggcgatggg atcatagtca gcccaagggg attaaagacc aatcaagatt 418501 atcgaacgtc agagcaaatt atcatccgcc gctgtgaggt tcggcggtcg aggagaaata 418561 acatttccat taccggatgt gacatggtca cggtggagga atgcttgatt gaagatgccg 418621 gaacggggaa tggaacagcg ccgaaattcg gaattgacat tgaaggatat ggcgaaggtg 418681 acgttgatta tgaggaaccg attaatgtat caattcgcaa taaccacttt gttggaaacg 418741 tttcaagttc tgtgaccaat tttaacgggt atggcatttt aatagaagga aatcactcag 418801 acaatacaat cagctacgga tatgggacgc aaacagtgat caagggcaat attctgagac 418861 gccctgaaga cgcggcggct gcgccaagag tcgggataac cggactcggt gtatcacaag 418921 gaaaagagac cagtgatgca gtgatcgctg gcaacctcat taccggattt tcaactggaa 418981 ttgatgtcag gggaaagagc gttcttgtga cgaacaacaa aatcagcaac tttgaaaaca 419041 cagggatatt ggtttatcag tcctccgacg taaaggtaga cggaaaccaa attcaaaacg 419101 gactgtctga aacaaggcgc agcatcggtc ttcgcgcagt gctgtcagat gacatcgcat 419161 ttctgaataa ctgtctcatt caagtcgttg acggtgtgaa cgtttccggc ggaaatatga 419221 tcattaaaga taatctcctg agaaaattca gccggggcat ttggattgct caagggaacg 419281 cggtgattga agggaataca ctgaatcctg acgcgtttga agcagtgccg gaatcatatt 419341 ctgtttccgt cacaaacaat gccggcgcca tcatcaaaaa caatacattt aaagagttca 419401 aaaattaccc catttattgc tccacaagtg caaaaacctc aattatcggc aaccacttag 419461 agcgatcccc gcttttggtc accatctata tcagcgcagg tgtgcatgag atttttgata 419521 ataccatttc agtcaacaga acagccggga atccgattgt gatttatctc aatggctctg 419581 caggctctat catctctgga aacaccatca ataacctctc cgcgggcact gcgacagcta 419641 ttcaaacaaa cacgtcaacc aattccaaaa tcatcggcaa ccgcattttt aaagggacca 419701 tcaacaaaca cagcagtgat acaatagacg gcaatatgat tgtctgaaaa aagcgccccc 419761 ctttaggggt tctttttttt cgatttatag atcacgtaca tttctctcac aagtactaac 419821 acaaaaaata aaagcacgac ccattccgca aatgttgtca tcttaaagct ggacatattg 419881 ttataaacgg cttttgttaa actgaaccct tgaagcatgt ccatcaacac agaaatagct 419941 aataaacaaa ttaatatgaa tccggtcacg cccaatatct tcatgcttca tcatcctccg 420001 cttttagtgt ctatctttgg cggagaagtt ataccgcatc taaccctaat gcataatctc 420061 aattttaaaa ggaagaatat gagaaaacga caaggaaagg tatttgtgta tgcctttatt 420121 ttctaagcga aagaacaata ccgattcaaa agacaagcag aatacagacg aaaggaatca 420181 ggaacagcag caagaaaaag aaaggccggt tctcatttct ccaagtttag caaagaatat 420241 agcggaaacg aaaaaggaag tcggaagcag ctctgacgtc atcattcgcg agattaaaat 420301 cggggagcag gatcatgtcc acctagctgt tatctatatt tctgggctgg tcgataataa 420361 cacgatccat gagtcgttaa ttgacccatt ggtacaggat gagtctatcc agaatactca 420421 tgcgatccag caaattcttg aaaaaacgct cccgctgggc ggggtgaaag cggaaaagag 420481 ctgggacaag cttttttccg agttaatgct tggcaatgcg ctcatttttg ctgatggcca 420541 tgatgaagct ttgatttgca gcactcaagg gggagagcag cgctccatcc aagagccgag 420601 cacccaggtg tcattccgcg gcccgcgcca agggtttaca gagtctctgc aaaccaatat 420661 ttccatgatc cggcgataca ttaaaaatcc gaatttatgg gttgaaaaaa tgaaaaaagg 420721 ttctgttacg aatacggata tcgctctcat gtacattcaa ggaatatgtg atgaaaaggt 420781 gctgaaggaa gtgaaacagc gcctggaaaa aatagatatt gacagtattt tggaatctgg 420841 atatattgag cagctgattg aagatgaaac ctttacgacg tttccgacta tgtatcatac 420901 agaacgccct gatgttgtag cgggtaatct gttagaagga agattcgcga ttattgtgga 420961 cggaacaccg tttgtgctta ttgccccagc cttatttgtc cagttttttc agtctgttga 421021 ggattattat tcgcgttttg acattgcgac aagcataaga attcttcgtg ttttagtctt 421081 tttcatttcg cttgtggcac cagctgtata cgtggcagcc acgacgtttc atcaagaaat 421141 gataccgact cagctgttag tggtcattgc ggcccagcgg gaaattgtcc cgtttccggc 421201 tgttgtggag gcgctgacga tggaggttgc ttttgagatt ctgagggaag cgggagtcag 421261 gctgccccgg gttgtcggct cggcagtgtc aatcgtaggc gcgctcgtaa tcggccaggc 421321 tgccgtacag gctggtatcg tctctccggc aatggtgatt atcgtggcac tcaccgcgat 421381 tgcgagcttc gcaacaccgg cgtttgcaat ggcgatttca gcccggctta ttcggtttat 421441 ctttattatt gcctcagctg ttatgggttt ttacgggctg attttaggga tcattatgat 421501 gtttgtccac ttatgcagtc ttcgttcatt cggcgttcca tatatgtcgc cgcttgcacc 421561 tttttcttca caaggcgtaa aggacgcgct tttccgggtt ccgtggtggg ccgatgaaaa 421621 aaggccggaa tcggtcagca aggaagataa ggtgcggcag gggaaagatc aacgcccaga 421681 gccggccgct tcacgaggaa tggtgaacaa agatttggaa gaaggggatc agaatggtac 421741 gtaaatgtct attagccgtt ctcatgcttt tgagcgtcat tgtgctgccc ggctgctggg 421801 ataagcggga gctgacggat cttgcgatta tctcggcgat tggcatcgat cggacaaacg 421861 acagcaacta cgtgctgcat cttcaaatta tcaatccagg aaatgttgcc ggcggccttc 421921 agggaggcgg tgctggagac aggccgcctg tatctgtcta ttcgattgaa ggtaacaata 421981 taacggaagc actcagaaaa gcctccatga aggtatcacg gcggctttat tttgcccata 422041 ccaatctagt cgtgatcaat gaaaagctgg caaaagaaga aggtttggat tttgtattag 422101 ataatcttga ccgggacaca gaattcagga caacagcaac attcgtcgtt gcccataaaa 422161 caaaagcaga aaatattgtg aaaatcttga cgccgattga taaaattccg tcaaataaag 422221 tcaataaaac actcgatttc acggaggcac aatacgggcg ggtggtcaaa atcaatattc 422281 aggacgtttt gaaaacactt gccgccaaca ctatggcacc ggtcatcccc ggatatatga 422341 tgattggtga cgataaaaaa ggagtcagca tggaaaacac gcaggcgact gacccgaaag 422401 ccattcttca ggcagatggt ttggcggttt ttgataaggc aggatattta aagtattggc 422461 tggaagatga tgaaagcgtg ggggcagtct ggcttatgaa taagatccag catacgttta 422521 ttaatgctga ctggggcaag acgaaggatg cggtcagctt gcaggttacc catcaagata 422581 caaagctggt accgaaaatg cggaacggac gcccgtacat ccatgtgaaa gtgtcggttg 422641 aaggtattat agatgctgtc aaataccctt tccaattgtc tgatcccaag gtgctggccg 422701 ctattgaaaa agcgctcaac aaagagcttg aaaaggaaat cagccatact gtgaaaaaga 422761 ttaagaagaa taaaatagat tttatcggtt ttggtgacac gatatataga aagtatccgg 422821 agcagtggga gaaaatgaag gacacttggg acaaagaata tttgccggaa ctgcccatcg 422881 atgtgaaggc cgagacgtat atcagaagga cgggattgcg aaacaatccg atcaaacacc 422941 agtttaaaga tgattaggtc tgaagaaagg ggaagtgaca gatggaaaaa gccagaataa 423001 gcataaggca gttgtttgtc atgattatca tttttgaact gggcagctcc ttattgatta 423061 caccgggatc aatggcgggc agggatgctt ggatagcagt tttattaggc tgtgcgatcg 423121 gactgtttct tttctatttg tatcaaggca tttatcaatg ttatccgaat tcttctccga 423181 aagaatatat ggatgatatg ctgggaacca agctgagctg gctgttttca tttctctata 423241 tcttgtactt tgcctatatt gccgcaaggg tgctgcgtga ctttggagaa atgctgctga 423301 cgtttgctta tcatgataca cctatcatta ttgtaaatgc tttattaatg gtagtaagca 423361 tatatgccgt aagaaaagga attgaagtac tcgcacgcgc ggccgaactt cttttcgggg 423421 ccatgtattt actgggcgcg atcggccttg tgctgattat tgtctcaggg actatagacc 423481 cgcacaattt aaagccggtt ttggcaaacg gcatttctcc tgtccttcac tctgttttca 423541 cacagaccat gtacgttcca tttggtgaag ttgttttatt tgtgatgatt ttccctaacc 423601 tgaatgacag aaaagatgtg aaaaaaatgg ggatgatcgc catggctatt agcggattga 423661 ttgtggcgct caccgtggcg attaatatta gcgtgcttga tgttgatctt acactcagat 423721 cccagtttcc gcttttaagc acgatccaga caatcaaggt cgaagaattt ttagaccggc 423781 tcgatgtctt ttttatgctg gcgctgatca tcggcggctt ctttaaggtc agcctctact 423841 tatatgccac tgtggttggg acatctacgc tctttaagga aaagaacccc tctcaattgg 423901 cttatccgat gggattgggc atcttaatcc tttctataac gatcgcgact aacttttcgg 423961 agcacttgaa tgaaggcctg aacgtggtgc cgctgtatat tcatttgcct tttcaattat 424021 tgtttccgct ctttctgttt attgtggccg tttggaaaaa gaaacgaaga gagaagtcaa 424081 aaggggagga agcaaaaaaa tgataaaaag agcgggggga tgcggccgcc gctcttttta 424141 tgttcacttc tatataaaag ggggatatag ggtgcgcccc tgtctgcact ggcagaggcg 424201 cgttttgtta tacgactgcg acgttttcct tcacagtaaa acttcctctt gaaagtctga 424261 tattgatgtc tgacactttt gcaatttgtt catcgtgcgt caccataatg acgcatttat 424321 cttccttgtg cgccagatcc tgaaagagcc gtacgatctc ttttgatgtg tcctcatcaa 424381 ggtttccggt cggttcatcg gctacgataa gatccgtgtc acagcagaaa gcccttgtaa 424441 ttgatacccg ctgctgctgt ccgccgctca gtgtgagcac tttttgccgg gcttgttttt 424501 cgttgatgcc aaccttctgc agcatgtcaa gcgcatatga ttctttgttc ttttctttag 424561 aacctgtgat ttccatagcg gttgtgacgt tctgcaaagc cgtcatatac gggagcaggt 424621 tgtacgcctg aaagacgatt gatacatatt gatttctgaa attggttaag ccgattttag 424681 aaaccgcttt tccgtcgtaa aggatgtttc cttcttttgg tgcgtcaagt ccgcctgcca 424741 gagacaggaa agtggttttc cccgtccctg atgttccgac gattgtgtag aattttcctt 424801 tttgaaagct gatgttaata tcctgaaaca atggctggct tttgttttta taccagtagc 424861 cgacttgttg aaattgtaat aagctcatag gttccgcctc tttctattcc tgttttgtca 424921 atatcgtttt cggatgaagc cgcagtactg aaattgacgg cagcaatgtt gcaatgattg 424981 cgattaggat gccgatcccg ccaagtataa gcatgtcgtt catagaaacc gcgacgttca 425041 gtgaatcgat aacgtccacg ttggatgaac tgtggccgaa cattttgccg cccatgccgc 425101 caccgccgcc gggcatttgt ccgcttgcgg tttgcgttga atcggttgat gaactgattt 425161 gctgggataa aagctgattt ccaagctgat tcgcgacgag atttcccgtc acagatgcaa 425221 ggccgatagc gataacggcc acaatcagaa tctcagtcaa gaactgtcca atcaatttcc 425281 atcgtttttc accgatggcc attaacacgc ccatttcgta tttgcgctcc ctgattgaca 425341 tcatgacaat caggccaaga atgacggcgc ctgccactga tacaagatac accacgtttt 425401 tagagaaaga agccacattt tcaatcggtc cgaccatttg ctggtaaagc tgatcgtttg 425461 tattcagtgt gtacgtatca aagtcaattg atgttttctt cgctgctttt acgaaagtat 425521 ccatattttt cgcgtcgtcc atatagtaaa cagctgagtc aatcgtattt ttatagtcgt 425581 cgcctttcaa tgccgctgtt gctgtgtaag gcgtataaag cttgttataa ggatttaaga 425641 aagagaaatt ttgggcttgg tcatcacctg aagatgttgt tttataaata ccgacgatct 425701 tcagttttac tgttgtatcc tcatccgttg ctgattcaat tgtgatcgaa tcgccaacgc 425761 ttaaatcatt ttcttccgct aatgtttcgt tgatcactgt tacttttttg ccgacatctg 425821 attttgtaat cgcgcgtccg tctgtgattt ttgaatctcc gtcagagaaa tcatcgacta 425881 acgctgtgct gatgacacct tcaatagaaa gatcagcttg aaccatttgc ggtccgcctt 425941 gtcctccgcc ttgactgttt ttagcgtttg agcttgaact gctggagctg gaatcacttg 426001 aactagagct ttcaatcgca tcaaagtttc ccgcgttggc tgaagctgat gtggtgtaat 426061 tgtagctctt cacatgatca agcgctgcaa gcttattcgc atcagacact ttgatcggtg 426121 tggattcgaa gctgcgcttt tcaccgctgt cctgctgttt ttccatttgc ttttggcggt 426181 caacctgaag tgtcacgctt ccaccgagtt cctgtctggc cagttcgctt gacttttgtg 426241 ctgccgactg gatggcgagg cctgatagaa caaagacaca tatgactgta aacacaaata 426301 attgcaataa cgtttttccc tttttagcct tcatattcca aaaggcccgt ttgataaagt 426361 tcatttatgt tcctccgtat aggtattttt attgataaga ccgcctctgg ggcgcgtccc 426421 cttgctgata aattaatagt agtccaaagg tatgaaaaaa atatgaacaa tctatttcta 426481 gttgatgaaa taaaaactaa caattgtgaa acgcaaaacc ttctgtttaa aatggtgcta 426541 ttatataaaa aagcatcaaa acaaccggag gatataatga aaatattaat gatagaagat 426601 aatgttagtg tatgtacgat gacggagatg ttctttttta aagaaggttt tgaagccgaa 426661 ttcgttcatg acgggttaga agggtaccag cgttttacgg aagaaaattg ggatctaatc 426721 attttggata tcatgcttcc atctatggac ggcgtgacca tctgcagaaa aataagagag 426781 acaagcacgg tgccgattat catgctgact gccaaagaca ctgaatcaga tcaggtcatc 426841 ggttttgaga tgggggcgga cgattatgtc acaaagccgt tcagcccgct gacattggtt 426901 gcccgcatca aagccgtcat cagaagatat aaggcgacag gcaaagcggt tattgatgaa 426961 gatatgattg aaacggaatg ctttaccatt aataagaaga cgagagaagt attattaaac 427021 ggagagcctg tagaaaatct cacgccgaag gaattcgatc tgctttatta ccttgtccaa 427081 aatccgcggc aggtgttctc cagagaacag ctgcttgagc aggtatgggg ctatcaattt 427141 tatggagatg agcgaacggt tgacgttcat atcaaacggc tgcggaaaaa gcttgccagc 427201 gaggacaagc ctttcctgta tactgtgtgg ggagtagggt ataaatttga tgaagattaa 427261 atatttatat cagctgctgc taagccatat cagcattttg attttagcgt ttgtcattat 427321 catttctctg ttttcccact ttgtgaagga atttgcctat cagaacaaag tagaggaatt 427381 gacgtcatat gcggtgcaga ttgcaaatga attccaatcc ggccaggtgg acatgcgcag 427441 gctctatcct tatcaggaca ttttaagcac aagaaagacg caatttatca tctttaatga 427501 agagcagcag ccttattttc ttcctgaagg ctttcatcac ccaccaaggg aacagctgaa 427561 gaaatcagaa tggaataagc tgaaaaaagg gcagactgtc acgatcaggg cagatggccg 427621 ttttgatgat gaagtgtccc ttgtggcgca gcctatattt gttcagaacg aatttaaagg 427681 cgccgttctg ctgatttctc cgatcagcgg tgttgaacag atggtcaatc aggtcaacct 427741 ctatatgttt tacgctgtga tcagcacgct tgtgattacg attcttgtga gctggcttct 427801 gtccaaattc catgtcaagc ggattcaaaa gctgagagaa gcgacagata aagtggcttc 427861 cggcgattat gacatccatt tggaaaacag ctacggggac gaaatcggcg tactggcgtc 427921 tgactttaat atcatggcga aaaaactaaa gcagtcaagg gatgaaatcg agcgccttga 427981 gaagcggaga aggcagttta tcgctgacgt gtcacatgaa ttaaaaacac cgctgacgac 428041 gatcaacggt ttggttgaag ggttgaacag ccatacgatt cctgaggata aaaaggataa 428101 atgcttctcg ctgatcagtg aggaaacgaa gcgcatgctg cggctcgtaa aagaaaatct 428161 ggattatgaa aaaatcagat cccagcaaat taccttgaac aagctagacg ttcctctgat 428221 cgaggtgttt gaaatcgtga aagagcactt gcagcagcag gcggaagaaa aacaaaacaa 428281 gctgatgatc caagtagagg atcacgtcat cgtacatgcc gattatgacc ggttcattca 428341 aattctcgtc aacattacga aaaacagcat ccaatttacg caaaacggtg acatttggct 428401 gcgcggaatg gaaggttata aagagacgat tattgaaatt gaagacacgg gtatcggcat 428461 tccaaaagag gatattgagc atatttggga gcgattctat aaagcagata tttcaagaac 428521 gaacacagca tacggtgaat acggactcgg tctctcgatc gtcaggcagc tcgttgaaat 428581 gcaccagggc acagtagaaa tcaagagtga agaagggaaa ggcacaaagt tcatcatccg 428641 ccttccttta acggcaaaac agcaatagca tacagggcgg cgcatcaact gatgcatccg 428701 ccttttttgc acaccgcttc ggtttattgc gtgctcccga aaacaaagat tgcgtgtttt 428761 tcgggttggg acggcctata aacatgataa aatatgacat aaacagtttt tgatgggaga 428821 gggtgaagga atgaagagtg gggtaattcc ttcttcagcg gtcggtcaaa aaattaacga 428881 gtggtacaga tatatccgga cattcagcgt gccggatgcc gaagtgttaa aagctgaaat 428941 ccagcaggaa ctgaaacaca tgcagcatga ttccaacttg ctgctttatt attcactaat 429001 ggaattccgg caccagctta tgctggatta tcttgagccg ttagagaaat taaatatcga 429061 agaccagcca agcctgtctg aattatcaag aaacattgac agcaaccagg cagatctcaa 429121 agggctgctc gactattacg tgaatttttt tcgcgggatg tatgaatttg ataagcggga 429181 atttatttct gccattacat actataaaca ggcggagaaa aagctctcct ttgtcgcaga 429241 ccatattgaa cgggctgaat tctattttaa aatcgcggaa gcttattatt atatgaagca 429301 aacgtatttt tcattgatta atataaaaaa cgcctatgaa atttacgtgg agcaggaaac 429361 ctataatgtg agaatcattc agtgccattt cgtcttcggg gtcaacctga tggatgaaag 429421 aaatttcgaa caagccgcac gccatttcaa attggcgctc aacatggccc aagcagaaca 429481 aaaagcccag ctggttggaa gagcatacta caatctcggg ttatgctatt acaatcaaga 429541 ccttctagac cctgccattg attactttga aaaagcggtc tccacatttg aaagcagcag 429601 gatcgtcaat tctctcccgc aagcctattt tttaatcacc ctgatttatt ataaacaggg 429661 aaaacatgat aaagcttcgg aatatcacaa gcggggctat gaatatgcta aagaaacaga 429721 cgatgcagac tatgccgtaa aattcgagtt tttgcaatcc ctatatctgg atcagcccaa 429781 tgaagaagga atcgaacgat gtttccagta cttaaaaaat aaaaatatgt acgctgatat 429841 agaggattta gccctagaag tagcaaaata ttactatgaa cagaaatggt ttaaactgtc 429901 tgcttcctac tttctacaag ttgaagaggc aagaaaacaa atacaaagga gtgaaggttt 429961 gtatgaaatt gaaatctaag ttgtttgtta tttgtttggc cgcagccgcg atttttacag 430021 cggctggcgt ttctgctaat gcggaagcac tcgactttca tgtgacagaa agaggaatga 430081 cgtaagaaca agccccttct cattagcgag aaggggtttt tcttttcaaa aaaacaccgc 430141 aagacatagt cttgcggtgc cgccttcatg gagattacgt ttatttagta gcctcctaca 430201 aatgcagttc ccacaatgat caagaggata aataacacaa caatcaaagc gaaagaagtt 430261 ccgtaacctg acattttgtg cacctccttg cgagattgct tcagcaaatg ctgcaaaact 430321 gtggcggaca gggtcccgca gagacggtca gcagcttaga agccgccaac aaacgcagtc 430381 cctacgataa ttaatagaat aaacaataca acgattaaag cgaaagaact gatgccgccg 430441 taaccgccgc cgttagagta tcctgacata aggtttcacc tccctatgaa ggatactata 430501 agatatgctg aaccgatcca tttggcaggg ataatagtgg acaagagaaa aaatgaagaa 430561 ttcggctata tgaaggtgat ataaaaaaat agcgggcgct gccgcccgct atttatgtac 430621 gattaagaga tcagcacgcc cgcgaaaaat tcctggtata acgcttgaac ggcttttctt 430681 tcttcggctt cttttacgcc aaacatcatg ctcacttcag aagacccctg attgatcatt 430741 tcgatattca cctgtgcctc tgataatgct ttggcggctc ttgccgttgt accgacattg 430801 tggcgcatcg cttcccctac aaccataatc agggcgagat gatgctcgac gatgacttca 430861 tcggcatgca aatcctcttc gatccgtttg atgacgctgc gttcagtggc ggcatccatt 430921 tgcccctgcc gtaaaatgat tgtcatgtca tcgattcccg atggaacatg ctcatacgtc 430981 aaaccatgct cctccaggat ttgaagggct ctgcggccaa aaccgatttc tctgttcatg 431041 agatacttgc tgatataaat gctgcaaaaa ccggtgtcgc tggcaatgcc gacgacaggc 431101 ccgtttgtgt tatcccgctt gctgacgacg cgggtgcctt cggctgaggg gttgttcgta 431161 tttttgatct gaacaggaat ccccgctctg aatgccggaa tgagcgcttc atcatgaaac 431221 actgaaaaac ccgcgtagga cagctcccgc atctctctat atgtcagctc gctgatttcc 431281 tttggattct caacgaagga cggattgaca gaatacacag cgtctacgtc tgtaaagttt 431341 tcgtacaaat cggcttgtag tccgttggca agaatcgaac cggtaatatc agaaccgctc 431401 cgtgagaatg tgatcacatc gccatccttg ctgaatccga aaaaaccggg aaaaatgatg 431461 agtccgtcac gttcccgaag acgatagagg ttttgatagg attcaggaag aacttgcgcg 431521 ttgccgggtt catttgtcac aaagaggccg gcatccttcg ggtttacata ttccgctttg 431581 acgcctttat aacggaagta agcggcgatc agtttggcat tgttatcctc tccgctggcc 431641 ttgactgcgt caaggtattg ttcgggattg cttttgtctc cttctaaaag cgtaaacaga 431701 tcatctctga ttttttcgat aatgctttgc cccagctgaa gctcattggc gatgagagcg 431761 taccgttcca caacagcttc cgccagttca ggtgcgctgc ctgttgccaa atattgttct 431821 gcacatgcga ttaagagatc agtcactttc gtatcctcgg catagtgttt tcccggagct 431881 gaaacgacta cagctttccg tgccggatct gaggtaacga tgtgaaacac cttgtcaagc 431941 tgggcgcctg aagcaagtga gctgcctccg aatttaacga ccttcatgtt tacatctcct 432001 aatgtttaaa attttcacac aaatttagta tttattatct ctctttcagt actgtaaatc 432061 aagggggaat ttctttctca ggagaacatt tgtatttttc acgaggaata atgttaggtt 432121 tgctgaccgt atgcctgcgt tataaagata aatatggtaa acagcctaac gttttgggat 432181 ggaaaatggt tagaatgatt agtaaaattg ataaatgact aggttaatat ttttaaagaa 432241 tattgactaa ccctataaaa atggtaatat gtaaatgata atgataatca attactatat 432301 ggccatattg ttttgagtcc ttgcggagta ggagatacgt tctttttgct gtaaggatgt 432361 aaggaggcag catgaagcta cgttacttat ttattctact tatcatatta gcagtcacat 432421 ctgtatttat cggtgtagaa gatctgtcgc cgcttgatct cttcgattta agcaaacaag 432481 aggcgtcaac gctgtttgca agccgtttgc cgcgattgat cagcattgtc attgcgggat 432541 taagcatgag catctgcggt ttgattatgc agcagatcag cagaaataaa ttcgtgtcac 432601 cgacgacggc gggcacgatg gattgggcga ggctcggcat tttaatttcc ttgctgctgt 432661 ttacatccgc cagtccttta atcaaaatgc tggtcgcgtt tgtctttgcc cttgcaggaa 432721 attttctgtt tatgaaaatc cttgaaagaa tcaagtttaa cgacaccatc tttattccgc 432781 ttgtcggttt aatgctcggg aatatcgtca gttcaatcgc gacatttatc gcatataaat 432841 atgacttgat ccagaatgtg tcatcatggc tgcagggaga cttctcttta gtcgtgaaag 432901 gaagatacga gcttctttat ctgagtattc cgctcgtcat cattgcctat gtgtatgcgg 432961 ataaattcac attggccggt atgggtgaaa gcttttctgt caacctcggc ctcaagtata 433021 aacgggttgt gaacatcggg ctcattatcg tgtccctgat cacgtctctt gtcattttga 433081 ctgtcggtat gctgccgttt ctcggtttaa tcatcccgaa tattgtatcg atttacagag 433141 gagacaatct gaagagcagc ctgccgcata ctgtgctgtt gggagcggtt tttgtgctgt 433201 tttgcgatat actgggcaga atcattatct tcccttatga aatctcgatt ggcctgatgg 433261 tcggaatcat cggcagcggc attttcctgt ttatgctgtt aaggagaaaa gcctatgcgt 433321 aaccagatga aaatagcttt gctcgttggt ttagccattg tatgtattgg cttgtttttg 433381 ttttatgact taggcaattg ggattacacc ctgccgagac gaatcaaaaa agtcgctgcc 433441 attgtgctga ctgggggagc gattgcgttt tcgaccatga tctttcaaac gattacgaac 433501 aaccgcatcc tgacgccgag cattttgggc cttgattctc tctacatgct gattcagact 433561 ggcattatct ttttgttcgg ttctgcgaat atggtcatca tgaataaaaa catcaacttt 433621 atcatctctg ttctgctgat gatcctgttt tctcttgttt tgtatcagat catgttcaag 433681 ggtgagggga gaaatatctt tttccttctg cttatcggaa tcgtgtttgg cacgctgttc 433741 agcagcctgt cttcttttat gcagatgctg attgatccga acgagttcca agttgtgcag 433801 gacaagatgt ttgccagctt taacaatatc aatacggatt tgttatggct cgcgttcatc 433861 atcttcctgc tgacaggcgt ttatgtctgg cgttttacaa aatttttcga tgtgctgtcg 433921 ctcggacgcg agcacgccgt gaatttgggc attgactacg acaaagtggt gaagcagatg 433981 ctgatcgtgg ttgcgatttt ggtttctgtt tcaacagcgc tagtcgggcc gattatgttt 434041 ttaggccttc tggtcgtcaa cctggcgaga gaattcctga aaacatataa gcattcatac 434101 ttaatcgcag gctccgtttt catcagcatc attgcgctgg tcggagggca gtttgtggtt 434161 gagaaagtgt ttaccttctc aacgacgctg agcgtcatta ttaattttgc cggcgggatt 434221 tattttatct acttgctgtt aaaggagaat aaatcatggt agaggtcaga aatgtaagca 434281 aacaatatgg cgggaaagtt gttcttgaag agacgtcagt cacgattcaa aagggcaaaa 434341 tcacctcgtt tatcggtcct aacggcgccg gcaaaagtac gctgctgtct atcatgagcc 434401 gcctgatcaa aaaggattcc ggcgagattt acatagacgg acaagagatt ggagcatgtg 434461 acagcaaaga gcttgccaag aaaatgagca ttttgaagca ggcgaaccaa atcaatatca 434521 ggctcacgat caaagacctc gtcagttttg gcaggtttcc gtactcacag ggccggctga 434581 cagaggaaga ctgggttcat atcaaccagg cgcttagcta tatgaagctg gaagacattc 434641 aagacaaata cttggatcag ctgagcggcg gacagtgcca aagggcattt atcgccatgg 434701 tcattgccca ggacacagat tatatctttc tggatgaacc gctgaacaat ctggatatga 434761 aacactcagt tgaaattatg aaactgctga aacggctggt agaggagctt ggaaaaacga 434821 tcgtgatcgt cattcacgat atcaattttg cttcagtcta ttctgactat atcgtcgctt 434881 tgaaaaacgg ccgaatcgtt aaagaaggac cgcctgaaga aatgatagaa acatcagtgc 434941 ttgaggaaat ctacgatatg accatcccga ttcagacgat tgataatcaa agaataggtg 435001 tttatttttc ttaatatata gaagaggtga ggagcatgaa aaagttcgcg ttactattca 435061 tcgctttggt cactgccgtt gtcatttctg catgcggaaa ccaaagcaca agcagcaaag 435121 gttctgatac aaagaaagaa caaatcacag tgaaacacca gctcgacaaa aacggcacaa 435181 aagtaccgaa gaaccctaaa aaagttgtcg tatttgactt tggaagctta gatacattag 435241 ataaactagg acttgatgat atagtagcgg gcctgccgaa acaagtcctt cctaaatatc 435301 tgtccaaatt caaggatgac aaatacgctg atgtcggcag cttaaaagag ccagacttcg 435361 acaaagtggc agaattagat cctgatctga tcattatttc agcaagacaa tctgagtctt 435421 acaaagaatt ctctaaaatt gcgccgacga tttaccttgg tgtagataca gcgaagtaca 435481 tggaatcatt taaatcagac gctgaaacaa tcggtaaaat ctttgataaa gaagacaaag 435541 tgaaagatga gctcgcaaac attgatcact caatcgcaga tgtaaagaaa accgctgaaa 435601 agcttaacaa aaacggtctc gtcatcatgg cgaacgatgg aaaaatcagc gcgttcggcc 435661 ctaaatcaag atacggcctg atccatgacg tattcggcgt ggctccggct gatcaaaaca 435721 tcaaagcgtc tacgcacgga caaagtgttt cttacgagta catttcaaaa acaaaccctg 435781 attacttgtt tgttattgac cgcggtacag caatcggaga aacatcatct acaaaacaag 435841 tcgtggaaaa cgattatgtg aaaaacgtaa acgcagtgaa aaatggtcat gtcatctacc 435901 ttgattctgc tacttggtat ttatcaggag gcggacttga gtctatgacg caaatgatta 435961 aagaagtgaa agacggttta gaaaagtaaa accaaaaaga gcctccgcta aatagcgggg 436021 ctcttttttt gttaatcagc gtgccggctg ctgttcggca gggcgctgag gtttctttaa 436081 tgtgaatgag agaaggaagc cgacaagtgc aatgacggca gccactataa aagcggcgtt 436141 catgccgtgc agggcggcgt gcttcacatt tgtcgtgcct gcatgtgccg cctggttgct 436201 catcacggaa accaatagtg cggttccgat cgagccgccg acttggcgaa tcgtgttgtt 436261 catcgcagtt ccgtgcggaa tcaagtggcg cggcagcgca ttgattccgg ctgttgtcac 436321 cggcatcatg atcatggcgg tgcctaagag acgaacggtg tataaaacga caatccaagc 436381 gagtgacgta tggtcagtca gctgcataaa cggcagagat gtcaggaaga tgatgcagaa 436441 accggcaatc gccagccctc ttccgccgac acggtcaaaa attctgccga taatcggcga 436501 cataaagccc atcacaacgg ctcccggcag gagcataagc cctgtatcaa aagctgtgac 436561 gtctctgaca ttttgtgtat aaagcggcag gatggtttcc gtaccgatca ataatgcaaa 436621 gacgagggtt cccagcagtg ttgttaagct gaaaacgcca aacgtgaaga cgcggaattc 436681 cagcatcggt tttttaagct tcatttgtct tgtgataaac aagagcagcg cgatgacacc 436741 caccagcagt gaaatcaaga cggttgaact ggaccagcca taagagccga cgcttgagaa 436801 gccgtacaga aggccgccga acccaaatgt tgaaaggatg actgataaaa tatcaatctg 436861 tgtttttctt aaagtcgtca cgtttttcat caggatgctg gcaagaatca aatcaatcac 436921 agcaaacgga agaataatat aaaacaatga tctccaagag aaagcttcga cagcccatcc 436981 ggaaagagtc ggtccgatcg caggcgcgaa tgagatgacc aatccgacca tacccatagc 437041 ctggccgcgc ttttcaatcg gaaagattgt caggaataca gtctgcatga gcggcatcat 437101 aatgccggct ccagccgctt gaatgatacg cgctgtcagc agaaccggga agttcggcgc 437161 gaacgctccg acgactgttc cggcagtgaa aatgctcatt gctgtgatga gcagcgcccg 437221 gcttgtgaat ttctcaatta aaaacgcggt aatcggaatt aaaatcccgt tggttaacat 437281 aaatgatgtt gtcagccatt gtgcttggtt ggcatcgaca ttgaaatccc tcatgatatg 437341 gggaagtgca gtaatcaaca atgtctggtt caaaatcgcc acaaacgctc cggctaacaa 437401 aatgccgaca atgacagaac ggttaaaagg tttttgttca atacttgtgt tcaatacata 437461 tcccttcttt tctctaagta attaacagtg tttttaacat ggaaacgggc tgtgttaaaa 437521 caccggtttg ttccagatag ccaatcagtg atttgagtaa aaaagcgcgg ggttcttcct 437581 tcttcgcttc ttcctccagc atagcggctg cggatgtcag ttcatctacg tcatagtccg 437641 cggcggacag ggaagagatg cctttatgta attccttcag gctttccgat aataggactg 437701 atttatcctt tggcttgtag gaggatgctg aatgaatata aagctcgatg gcttcgggcg 437761 gaagaagaga ctggcgggtt tccctgtttt tgataatctg attgagggtg ctgatgataa 437821 actctgcgat cgggtcaagc tcaagcggtt tttcctcgat tttgatcagc attaaaaact 437881 cacgcatcat gccgtgaaga atgataacca aatcccacac aaacgggaga atggtttctc 437941 catacgcctg gatcagcgaa tcgcggtgcc agcagataat cgtcgatctg gtctgatgga 438001 tatgctgttt gacccggtca ttgtgcagct tggggtttcc gtaggtcagc atattgaaaa 438061 actgctgatt ccgcctgaag ccctccagtt ccattttgac cttttgcgtc aaacgctcct 438121 ccggtgtaag tgctgtattt tcctgaagtc ttgaggccgc ggccaccatt tgcttctggt 438181 taaatgacag cagctccaaa agcagatctt ctttagattg gaacagctta tatatcgaag 438241 cttttgacat cttacattct tctgcgatcg cctgcatgga aaccgacgta aaatcctttt 438301 ccgaaaaaag ctttcgcgcg gctaacaaga tatctgtttt tttatcaagc atctcatggc 438361 ttccttcttt cttgaacatt agaaaaccca ttggttcaca gaaaaccaat gagtaacaat 438421 gaaaaaattt taccagataa acaaaataga agtcaatgga ttttaaccgg gtaaatgaaa 438481 ggcctgccgg aaaatccgac aggccgaata agagcttatt tttcaacttt aaatccttgt 438541 ttttcaagca tttcacggat gtgcggatag tacaggcgct catagtagga agcgatgctc 438601 tgtgaccagt ttcttgtttc ttttccgttt gtccgtttat tcatgtattc agacatctgt 438661 tcgtcgtatg cctgaatgtg agacgtcagc tcatcctgat tcaaataagt ttcctgatga 438721 ttgacagctt cctgcggcaa gcgcggtttt ttcgctgaac ggtcggcagg atgcccaatg 438781 acaaggccgg ataaagggaa cacgtatttc ggaagctcaa gcagttcgat cagctcttga 438841 gggtttccgc gaactgcacc gatcggaact gtgccaagtc cgagtgactc agccgctgct 438901 gttgctgtgc cgagggcaat accagcgtct actgcgccga caagaacaga ttccaatcca 438961 tttgtgattt ccattttgaa atcatgcaga tcttcaagcg caattttggc ccggttaaaa 439021 tctgcgcaga acagcaggaa aacaggagct tgatcgatcc atggctggcc gcctgccagc 439081 tcggagattt tctttttgcg ctctttatcc tggactgtga tcacagtcac ttgctgtccg 439141 ttgatagaag aaggggctga ttgcaccgct tcaatgattt ggtccaattg ctcctgagct 439201 acaggctcat ctgtgtagct gcgaatcgag cggtggtctg ttaaagattt aatcacttca 439261 ttcatatgag acacccttcc tttactcgct aagctctgtg cggacaacat caagaggagc 439321 gctcagcagt tcttttcctt ttgcgacaaa cccttggaaa tgcgcagttt cgttatggaa 439381 tttcattgcc gcttcatctt tccatttttc aagcatgaca aatgtatttt cttcgcctac 439441 tttttcgaat aggtcgtatt gcgcgttgcc ttcctcagct cttgaatgct gaacaagtga 439501 ttgagcctcg ctcaaaaatt cctcgcgttt ttctggtttt actttgatgt aagcttgtaa 439561 tacgatcatg taaatctcct ccgtcgttat gcgaatttat tgttcgaatt tcatcgaact 439621 aaatgtaaca tgtattctaa atgaggtaaa ggaaaaaccc ttatatagta aaattgtcat 439681 tctaattgtt gtatgataca tttgtgtcat gaacattcca aaccatccag aaacagaaac 439741 attgcagctg acaaaggttc ttcatgcact tagtgatccg cttcgtttag agctcgtcaa 439801 gcaattagct gaagcaaaag aaaaaacgtg cagcacctgt gcagatgtgc aggttgccaa 439861 atcgactttg tcgcatcatt ttaaagtttt gagagaatca ggcatcgctc aagttcggat 439921 agaaggaaag cgccggtatt attcgcttcg cgctgaagac cttgaaaagg catttccggg 439981 actgcttgaa gccgtgctga atgtagacca ggaccgctgg tgaatcaatc ccctgtaacg 440041 gggatttttt tatgtccgta aaccgctttg aaaagccgct gcacaccctc ctgaatatct 440101 tcttccttca gccgtgcaaa gccgataatg agagcaggcc tgcccgtttg ccgcttgttt 440161 tccttcaagt taaatcggct cattccgaat atttcaagct gcagcccggc agcatgtgac 440221 aggatgtctt gttcggtgcg cctggtatca aattcggtaa caaaatgcag ccccgcattt 440281 gcccctttta cggtaacctc tccgctgaac tctgcttcta aagcggtgat caggcgttct 440341 ctcttttctt tataatgctg cttcattttt tttatatgct tctgatattc accagactcg 440401 ataaattcct gcagggtgag ctgtgtgagt gatgagcaag tctgcagatc atagccccgc 440461 tgtttgtatg ccctcaacag ctcaggcggc aacaccatat agctgatccg taagccgggg 440521 agaagggact ttgaaaaggt tcccatatag atgacatttt gaaaacggtc gaggctttgc 440581 agcgccggaa tactgtctac atcatatgtg aattcactat cataatcgtc ctcaatgata 440641 tatcggcgcg gctcctcggc tgcccagttc agcagctgaa ttcttctgga tacaggcata 440701 atcgttccgg acggaaactg atgcgacggg gtggtcacca gcacatctgg ctgctgtctg 440761 gtgatttcag caatcgacat gcctttttca tccagcatga tcgtctttac ttgttttccg 440821 gcattcttca aaagctgata catgcgcctg tagccaggct cctccatcgc atacacggct 440881 tccttgggta aaagctcagt caacagctgc atgagcacct gtgtgcctgc ccctatgatc 440941 atttgttccg gcctgcattt tacacccctc gtcagggaaa tgagcctcgt aatggccgct 441001 ctcacttcat atatcccttg cggatgtgac atatcgccga gcgtgcggta tgagcgggag 441061 gccgcttttt gctcgcagcg gaaccagctt ttgatcggaa aatggtctgt atcggaactc 441121 atgtgtgaaa acgatatcca atcgctctgg tcgatgtgaa tctcttttag gtcatccggc 441181 agtgcaaatg gagggtgctc ctcggcggaa aacatgtcta gttcctccac gaagaaaccc 441241 tttcgttcaa tggcgtacaa atacccctca gccagcagct gctgataggc tgaattcact 441301 gaatttacgc tgaccttgag attttcagcc agctcccgct tggagggaac cttcgagtgc 441361 ggcagcagat tgcggctgag gatttctttt ttcagctttt gataaatttg ctgatagata 441421 taatcggctt gttctgaacg atcgagtgta atcgtgatat ccattttgta gtttctcctt 441481 ctgataccat caaaaagtta taattggtac ttttcatcat accaaagaga agtcagaatg 441541 ataagaaaat accgacaggg ggatattcac atgagtcaaa caacagcaag catcacaact 441601 gcacaatggc agcaaaaacg ggatcaattt gtgtcaaaag gtgtgagcaa cggcaaccgc 441661 agtctggcgg tcaaaggaga aggggccgag ctgtacgatc tggatggccg gagatttatt 441721 gattttgcag gcgccatcgg cacgttaaat gtcggacact cgcatccgaa ggtggttgag 441781 gctgtgaagc ggcaggcgga ggagctgatt catcctggtt ttaatgtcat gatgtacccg 441841 acttatatcg aattagcaga aaaactgtgc ggcatcgcgc cgggcagcca tgagaaaaaa 441901 gcgatttttc ttaactcagg ggcagaagcg gtcgaaaacg ctgtgaaaat cgccagaaag 441961 tatacaaagc gccaaggcgt tgtctcgttt acacgcgggt ttcacgggcg cacgaatatg 442021 acgatgagca tgacaagcaa ggtaaaacct tataaattcg gtttcgggcc ttttgcgcca 442081 gaggtttatc aagcgccgtt cccttattat tatcagaagc cggccggcat gagtgatgaa 442141 agctatgacg atatggtcat tcaagcattc aatgatttct ttatcgcttc agtggcgcct 442201 gaaacggtgg cgtgtgtcgt gatggagcca gtgcagggag aaggcggatt tattattcct 442261 tcgaaacggt tcgtacagca cgtcgcttca ttctgcaaag aacacggcat tgtttttgtt 442321 gctgatgaaa tccaaaccgg ctttgccaga actggcactt atttcgcaat tgagcacttt 442381 gatgtagtgc ccgatctgat cacggtttct aaatcgcttg cggcaggcct gccattaagc 442441 ggtgtgatcg ggcgtgcgga aatgcttgat gcggcagcgc caggggagct gggcggcacg 442501 tatgccggca gcccgctcgg ctgcgcggcg gctttggcag tcttggatat tatcgaagaa 442561 gaaggactga atgagcgatc tgaagaaatt ggcaaaatca ttgaagacaa ggcgtatgag 442621 tggaaacaag aattcccgtt catcggtgac atccgcagac tcggggcgat ggccgcaatc 442681 gaaatcgtca aggatcctga cacgcgtgag cctgataaga caaaagcagc agcgatcgcg 442741 gcctatgcga atcaaaacgg attacttttg ctgacagcgg gaattaacgg taatatcatc 442801 cgctttttga caccgctcgt catctcagac agcctattaa atgaagggct cagcatcttg 442861 gaggcgggcc tgcgagctta atcattggaa agaaaatggc cgggtctgct atcattttaa 442921 gtaatcatga aaagaaagga atgttcaata tgccagatca attaacggtc tacaacccgg 442981 ctacgggcga ggagatcaaa acgattcctc agcaatcagc cacagaggta gaagaagcca 443041 ttgaacgttc acatcaagcg tttaaaacgt ggtctaaaac atcagcgaac gaaagaacgt 443101 ctcttttgaa aaaatggtat gagctgattg ttgaacataa agaagagctt gcagatttaa 443161 ttacaaagga aaacggaaaa ccataccagg aagcagtcgg cgaggtactt tacggcgcag 443221 gctatatcga atggttcgca gaggaagcga agcgtgtgta cggaagaacg gtcccggccc 443281 cgacaactgg taaacgaatt gttgtcacac gccagccggt cggccccgtt gctgctatca 443341 cgccctggaa tttcccgaat gcgatgatta cacgcaaagc ggcgcctgct cttgccgccg 443401 gctgtacatt tatcatcaag ccggcgccgg acacaccgct gtctgcttat gaactagcgc 443461 gcctcgcata tgaagcgggc attccgaagg atgttcttca ggttgtgatc ggcgatggag 443521 aagaaatcgg aaatgtgttc acaagcagtc cgaaaatccg caaaatcacg ttcacaggct 443581 caacacctgt agggaaaatc cttatgaaaa acagcgctga caccgtaaag cacgtctcaa 443641 tggagctcgg cggacacgcc ccgctgatcg tagatgaaga tgcggacatt gaccttgccg 443701 ttgaacaggc gatggcgtcc aaataccgaa acgccggcca aacctgcgta tgtgccaacc 443761 gcctgatcgt tcatgaatcc attaaagatg aatttgctgc gaaactgagc gagcaagtgt 443821 ctaagctgaa agtcggaaat ggacttgagg aaggcgtcaa tgtcggcccg attatcaaca 443881 aacgaggctt cgaaaaaatc gtcagccaaa tagatgatgc ggttgaaaaa ggcgcgaaag 443941 tgattgctgg gggcacatat gaccgaaacg atgacaaagg gtgctacttt gtgaatccga 444001 cagtgctcac cgatgtcgat acgtccatga acatcatgca tgaggaaaca ttcggcccgg 444061 tcgccccgat cgtcacgttt tctgatattg atgaagcgat tcagcttgcc aacgatacac 444121 cgtatggctt ggctgcttac ttcttcacag aaaactaccg ccgcggcatc tatatttccg 444181 agaatctaga gtatggcatt atcggctgga atgacggcgg accgtcagcg gttcaagcgc 444241 cattcggcgg aatgaaagaa agcggcatcg gccgtgaagg cggttcagaa ggtatcgagc 444301 cgtaccttga aacaaaatat ttgtccatcg gtttataaaa gaatgcacgc tcctgagagc 444361 tgccggattt tccggcagct ctttttgtgt tccggcgaat aatcacaaca attccagcca 444421 aaataacagc aaatacattt tgaaagaagg ttccccaaca atggatttat tattggctct 444481 tctcccggct ttgttttggg ggagcattgt tctcttcaat gtgaaattag gcggcgggcc 444541 gtacagccag acactgggaa cgacgatcgg ggcactcatt gtttctatcg ttatttactt 444601 ttttgttcag cccgttctgt cccttcgcat ttttattgtt ggaatcgtat ccggcttatt 444661 ttggtcactt ggacaggcca accagttgaa aagcattcaa ttgatgggcg tgtcgaaaac 444721 aatgccgatt tccacaggaa tgcagctcgt ttccacctcg ctgttcggtg tgatcgtgtt 444781 ccgcgaatgg tcaacaccga ttgcgattac gcttggcgtt ctcgctttga tctttatcat 444841 tgtgggaatc attctcacgt ccttggaaga taagaatgat aaaaaagagg gcgagccaag 444901 caatttgaaa aagggcattt tgattctcct tgtttcgact cttggttatt tggtttatgt 444961 agtcgtggct agattattca atgtgtccgg ctggtccgcg ctgctgccac aggcaattgg 445021 catggtggtc ggggggttag ttttaaccta tagacacaaa ccctttaaca agtatgcgat 445081 cagaaatatt ctcccagggt taatctgggc aggcggaaat atgtttttgt ttatttctca 445141 gccgcgagtc ggcgttgcaa cgagcttttc cctttcacaa atgggaattg tcatttctac 445201 gctcggcggt attttcatcc tgcgtgaaaa gaaaacgaaa cgccagctaa tagcaattgc 445261 gatcgggatt atcctgatta ttgccgccgc cgtattctta ggaatcgcca aaacaaattc 445321 ataacaaatg gaggaggatg tatatgtatc cggatttaaa aggaaaagtc gtcgctatta 445381 caggagctgc ttcagggctc ggaaaggcga tggccattcg cttcggcaag gagcaggcaa 445441 aagtggttat caactattat agtaataaac aagatccgaa cgaggtaaaa gaagaggtca 445501 tcaaggcggg cggtgaagct gttgtcgtcc aaggagatgt cacgaaagag gaagatgtaa 445561 aaaatatcgt gcaaacggca attaaggagt tcggcacact cgatattatg attaataatg 445621 ccggtcttga aaatcctgtg ccatctcacg aaatgccgct caaggattgg gataaagtca 445681 tcggcacgaa cttaacgggt gcctttttag gaagccgtga agcgattaaa tatttcgtag 445741 aaaacgatat caagggaaat gtcattaaca tgtccagtgt gcacgaagtg attccttggc 445801 cgttatttgt ccactatgcg gcaagtaaag gcgggataaa gctgatgaca gaaacattag 445861 cgttggaata cgcgccgaag ggcattcgcg tcaataatat tgggccaggt gcgatcaaca 445921 cgccaatcaa tgctgaaaaa ttcgctgacc ctaaacagaa agctgatgta gaaagcatga 445981 ttccaatggg atatatcggc gaaccggagg agatcgccgc agtagcagcc tggcttgctt 446041 cgaaggaagc cagctacgtc acaggcatca cgttattcgc ggacggcggt atgacacaat 446101 atccttcatt ccaggcaggc cgcggttaaa cataaaaagc gacccagaca tgacatctgg 446161 atcgctttct ttattaggca cgctttttct ttacaagtgc tgctacagat aaaataatgg 446221 cagccgcaga cagcaccatc gctgtaatgt ctagagctga agaacctgag ttttcggaat 446281 cgtcttctgt tttcgtggcg ccgtgctcat ctgtcacttg ctttgcagac gtgatgtttg 446341 taatggaatg aggtgtatcg gcatcctcgt cacctgtcca ctcaacaatg ctgccgtctt 446401 tgtaatattg gtatgcgtcc caagcagctt cctccgcttt gtcagggttt ttggcaacaa 446461 aggtaaactg ctggaactgg ccttcctgaa tgcctccgtc agtcgcctcc catgtcacgg 446521 atactgattt gtcatcatgt ttttgagtgg aaaccttcca gcccggaatt ggctcatatt 446581 gctggaattc aacatccttc ggcattttga ggacaacctt cgttgtcggc agatttttct 446641 cagaaggaac cttcattgta tacgtttccc aagagcctgc agcagactca gccggtttta 446701 cagaaacatg cgcgctggca ggggccgtaa agaataagag ggagccgaca atagccggac 446761 atagtgtcaa tgcgattttt ttcaacaacg taaacactcc ttaattggtc tttgtaaaca 446821 tgatattgat ttcgttaaag tcgccggtca ggccgtggac tttgatcttc cagtttcctt 446881 tttcattaat cgacaggttt tgatcttgga agacgccttt tgttttttct tttaatgtaa 446941 aggtgctttt gttttcgctg cctgacaggc ctgttttata aacggttaac gtgatttgct 447001 ggatgttttt cacgggatca ccgttatggt cggtgacccg cagctcaaaa acattttttc 447061 caggctggtt tgggctgatg ctgagagaaa cgctttgtcc gttctctatc gctttggttt 447121 ggtagaacgg ttccggcgct ggctcaggcg ggcttggcag gcttgtaaac acggccgctg 447181 tgatcaatac agcgatgccg attgcccact ccgctttcaa cgttcggctg attcctgtgc 447241 ggcgctgctt tctggtaagc agaaaatgaa ttgcgcctaa gaccagcatg aaaacaaaca 447301 gcccgctttt cactaaaaga gcttgtccgt acgctgtatg gaacagtgaa tccattgaac 447361 gaatgatgaa aaatccattg agcaagcctg aaaacaaaat gacgccgact gcagtgagcg 447421 cccatgggga gaaccgtctg accgtctccc acgcgagcgt tttgtcaggc tgcctccatt 447481 cttttgagag cagcaaaacg agtgccgcta ttccgccgac ccagatggaa gcggaagtta 447541 aatgaaggaa atccatcaaa atgccgaccg ttttttcttc aacgacagca gcatgcccgg 447601 taaacgcctt ggcaagcagg agaccgaaaa agaaaatgag cggcgctgtc caatagccaa 447661 aggatgaaaa gcggtttttc cgtatcgcag ggatgacaga cagtgcgagc agcacgaaca 447721 gcgcagcctg tatgatccaa atggagccgc ctgctgtctc aaacagtgtt tctctgatgt 447781 agcccggctg gaatgcgctg ccccagccgc cgcctgcgtt cgcttttgtc tgaatcggaa 447841 gctgaagcaa aagcgccagc cccaatgctg cgatcgagcc ggtcaggata cgtctcgtcc 447901 gtttgacgag ctgttctgat ttccctttat accagaaaag atggaagaaa accgttccga 447961 taaacagaga taaggctgta tacagaatcg cgcgatctgc tgctgttccc ggattcagcg 448021 ctgaatcggc tgctttttgg ctgctgaatc cgccatccgc tttcccgata ctgaacggaa 448081 tgacgccgga aacaggatgt ccatccgcgg atacggcatt ccattccgct ctgtacacat 448141 ctttaggcag attcttcttc agcttcactg tcatgatgtg atgattatct tttttgattt 448201 cagtcttgtc cgtatccaca cggtcgccgt ttgaattata gactttaatg taatgaaacc 448261 cttcttcaac cggttcatta aattcgattt ccacctgcgc aggggcgctt tttaattcgc 448321 tgttttcccc aggtgaagat ttgacaatat aggcgtgagc aaagcttgtt ttcggcagga 448381 aaacaagaaa aagcagaagg atgatccacc atctgtttcg cttcatcact cagacaccac 448441 cttccgctgt atgtgttgtg ttatttcttg gtgcaggtgc agcgtttctt tcggtcttga 448501 agcatgtctt ccagcgcttg gtcgaaagtg cagacggctc cgccgaatcc tttttgaaat 448561 cgttcggcat ggtcaagtgt cgcaaacgga atggcctgcg gctggcagca gtgcaggttt 448621 aattcagcat ttacgacgaa ataagccgaa ccggcactga cggttgtctg taacagaaaa 448681 tctctgcaaa tcaagtgtga aacctcttcc gttttatccg cgtaacgcaa aaacgcgcaa 448741 tgtgcgcagc atagctgttc aatgtcttgg tttaccgtaa tcagctgaac cgaatgagct 448801 tgattgacgg gcttcaagca atagctgcac atatgatctg tttgaggtgt tcggacgggg 448861 agcgtgatgc cgccggccgt tttaatgacc tgatttgact gaaccagctg attgacatct 448921 ctatataccg tcatttccga aacgccgaac cttgcgctga tgtcagaaat tctaagcgag 448981 ccttcttctt tcagccactt cagtatgtgt tgctgtctat taatcggaag cattcataca 449041 ccctcttcat taagatctat ttaagcgtag aggattttag agacggagac aagtaagtgg 449101 atgataaaaa atgtgaaaat gtgttgaaca gcaacaaaac gaaacagaag ggactctggt 449161 ataatagaca gatggaatag aaagtgagga ataccctatg aaagaaacac catgcccgaa 449221 ctgcggcaaa cctttgacag gcgatatggt cagatcatca aatgtgcctt gtcaatttcg 449281 ctgcggccac tgccgggaac ggctttatga atataaagtt tcagctccga ttatgctggt 449341 atcattagcg gccatcgtgc tgcttattta tcttttgatg ctcctccgca atgcggcagg 449401 ctcagtgctg ccagctgtac agcacgtgcc gatggctgta tttgcgcttg tgtgcgcgta 449461 tcccgttttt attgtgagtg agcggatgat tgcaaagtac gtgattcaaa atggcaacat 449521 catttataga ggaaagagaa aaggctcctg aaaccaggag cctttttatt tttaaaaaat 449581 tgtcacagtc atgtgccaaa gtcctcttta ctttcaattg tatagggact gtaagcgttt 449641 taacatagag tcaaagggaa gcatcattct ctgaacatat ttttgtatct tacagcgaca 449701 aacaaaacag ggagggttta tatatgcagc agcaagaaca gcagcaaggc ggcatgaaag 449761 tgaaagtgca acgctttggg agttatttga gcggaatgat catgccgaat atcggcgcgt 449821 ttatcgcgtg gggtatcatt accgcgctgt ttattccggc aggatggttt ccgaatgaac 449881 agctgaacac gctggtcagc ccgatgatta cgtatttatt gccgcttttg atagcgtata 449941 caggcggaaa aatgatctac gaccaccgcg gcggagttgt cggagcgaca gcggcaattg 450001 gggtgattgt aggatcggat attccaatgt ttttaggcgc aatgattatg ggtccgcttg 450061 gcggatacct cattaaacag actgataaat tattcaagga taaagtcaag caaggctttg 450121 aaatgctgat caacaacttt acggcaggga ttgtcggcgc ggctttaacg attctcgcgt 450181 tttacgccat cggcccggtt gtcttgacgc taaataaatt gctggcggct ggtgtggaag 450241 tcattgtaca cgctaattta ctgccggtag ccagtgtttt tgtagaaccg gcgaaagtgt 450301 tgttccttaa caacgccata aaccatggaa tcttaagccc gatcggaatc gagcaagcat 450361 ctcaaacagg aaaatcaatt ctgtttttag tagaagcaaa ccctggaccg gggctcggca 450421 ttttgctggc ctacatgttc tttggcaaag gatcttcaaa atcaacggct cccggtgcgg 450481 cgatcatcca tttcttcgga gggattcacg agatttactt cccgtacatt ctgatgaaac 450541 cggccctgat tctcgcagcc attgccggcg gagcaagcgg actcttaaca tttacgatct 450601 ttaatgccgg acttgtcgcg gcagcgtcac cgggaagcat tatcgcattg atggcaatga 450661 cgccaagagg aggctatttc ggcgtattgg cgggtgtatt ggtcgctgca gctgtatcgt 450721 tcatcgtttc agcagtgatc ctgaaatcct ctaaagctag tgaagaagac ctggctgccg 450781 caacagaaaa aatgcagtcc atgaagggga agaaaagcca agcagcagct gctttagagg 450841 cggaacaagc caaagcagaa gaagcgtctg agctgtctcc tgaaagcgtg aacaaaatta 450901 tctttgcgtg tgatgcggga atgggatcaa gtgccatggg ggcatccatc ttaagaaaca 450961 aagtgaaaaa agcggagctt gacatcagtg tgaccaacac ggccattaac aatctgccaa 451021 gcgatgcgga tattgtcatc acccacaaag atttaacaga ccgcgcgaaa gcaaagctgc 451081 cgaacgcgac gcacatatca gtggataact tcttaaacag cccgaaatac gacgagctga 451141 ttgaaaagct gaaaaagtaa tcttatagaa agagagtgat tgtcatgcaa gtactcgcaa 451201 aggaaaacat taaactcaat caaacggtat catcaaaaga agaggctatc aaattggcag 451261 gccagacgct gattgacaac ggctacgtga cagaggatta cattagcaaa atgtttgaac 451321 gtgaagaaac gtcttctacg tttatgggga atttcattgc cattccacac ggcacagaag 451381 aagcgaaaag cgaggtgctt cactcaggaa tttcaatcat acagattcca gagggcgttg 451441 agtacggaga aggcaacacg gcaaaagtgg tattcggcat tgcgggtaaa aataatgagc 451501 atttagacat tttgtctaac atcgccatta tctgttcaga agaagaaaac attgaacgcc 451561 tgatctccgc taaaagcgaa gaagatttga tcgccatttt caacgaggtg aactgacatg 451621 atcgccttac atttcggtgc gggaaatatc gggagaggat ttatcggcgc gctgcttcac 451681 cactccggct atgatgtggt gtttgcggat gtgaacgaaa cgatggtcag cctcctcaat 451741 gaaaaaaaag aatacacagt ggaactggcg gaagagggac gttcatcgga gatcattggc 451801 ccggtgagcg ctattaacag cggcagtcag accgaggagc tgtaccggct gatgaatgag 451861 gcggcgctca tcacaacagc tgtcggcccg aatgtgctga agctgattgc cccgtctatc 451921 gcagaaggtt taagacgaag aaatactgca aacacactga atatcattgc ctgcgaaaat 451981 atgattggcg gaagcagctt cttaaagaaa gaaatataca gccatttaac ggaagcagag 452041 cagaaatccg tcagtgaaac ggtaggtttt ccgaattctg ccgttgaccg gatcgtcccg 452101 attcagcatc atgaagaccc gctgaaagta tcggttgaac catttttcga atgggtcatt 452161 gatgaatcag gctttaaagg gaaaacacca gtcataaacg gcgcactgtt tgttgatgat 452221 ttaacgccgt acatcgaacg gaagctgttt acggtcaata ccggacacgc ggtcacagcg 452281 tatgtcggct atcagcgcgg actcaaaacg gtcaaagaag caattgatca tccggaaatc 452341 cgccgtgttg ttcattcggc gctgcttgaa actggtgact atctcgtcaa atcgtatggc 452401 tttaagcaaa ctgaacacga acaatatatc aaaaaaatca tcggtcgctt tgaaaatcct 452461 ttcatttcgg acgatgtgac ccgcgtagcg aggtcacctc tcagaaaact gggagaaaat 452521 gatagacttg taggcccggc aaagaaaata aaagaaccga atgcactggc tgaaggaatt 452581 gccgcagcac tgcgcttcga tttcaccggt gaccctgaag cggttgaact gcaagcgctg 452641 atcgaagaaa aaggatacag cggcgtactt caagaggtgt gcggcattca gtcccatgaa 452701 ccgttgcacg ccatcatttt aaagaaactt aatcaataac cgaccacccg tgacacaatg 452761 tcacgggctt tttttactat ctcgcaatct agtataatag aaagcgctta cgataacagg 452821 ggaaggagaa tgacgatgaa acaatttgag attgcggcaa taccgggaga cggagtagga 452881 aaagaggttg tagcggctgc tgagaaagtg cttcatacag cggctgaggt acacggaggt 452941 ttgtcattct cattcacagc ttttccatgg agctgtgatt attacttgga gcacggcaaa 453001 atgatgcccg aagatggaat acatacgctt actcaatttg aagcagtttt tttgggagct 453061 gtcggaaatc cgaagctggt tcccgatcat atatcgttat gggggctgct gctgaaaatc 453121 cggagggagc ttgagctttc cattaatatg agacccgcca aacaaatggc aggcattacg 453181 tcgccgcttc tgcatccaaa tgattttgac ttcgtggtga ttcgcgagaa cagtgaaggt 453241 gaatacagtg aagttggcgg gcgcattcac agaggcgatg atgaaatcgc catccagaat 453301 gccgtgttta cgagaaaagc gacagaacgt gtcatgcgct ttgccttcga attggcgaaa 453361 aaacggcgca gccatgtgac aagcgccaca aagtctaacg gcatttatca cgcgatgccg 453421 ttttgggatg aagtctttca gcagacagcc gctgattata gcggaatcga aacatcatct 453481 cagcatattg atgcgctggc cgcttttttt gtgacgcgtc cggaaacgtt tgatgtcatt 453541 gtggcgagca acttgttcgg tgatatttta accgacatca gctcaagcct gatgggaagc 453601 atcggcattg cgccttctgc gaacatcaat ccatccggca aatatccgtc catgtttgaa 453661 ccggttcacg gctcagctcc tgacattgcc ggacagggcc ttgccaatcc gatcggccag 453721 atttggacag cgaagctgat gctcgaccac ttcggagagg aagaattggg ggcgaaaatt 453781 ctggatgtaa tggagcaagt gactgccgac ggcatcaaaa cacgcgacat tgggggacaa 453841 agcacaacgg ctgaggtcac tgatgaaatc tgttcgcgct taagaaagct ctgatgaatc 453901 aggccggtgg cagatggctg ccccggcctg tccatttcct tacgaaaatt tccacgaaag 453961 tctaaccaag cagatccaaa tgctgtataa taatttggaa ttcttaggaa agcatcgggt 454021 gaaggaagtt gaatgcaaaa acaatcacgt taaagaaaaa aagaaaaatc aaaacgatcg 454081 ttgtactcag tatcattatg atcgcagctc tcatttttac gatcagattg gtgttttaca 454141 agccttttct tattgaagga tcatcaatgg ccccaacgct taaagactca gaaagaattc 454201 tggttgataa agcagtcaaa tggactggcg ggtttcacag aggagacatc atagtcattc 454261 atgacaaaaa gagcggccgc tcatttgtca aacgtttaat cggtttgcct ggtgacagca 454321 ttaaaatgaa aaatgatcag ctatacataa atgataaaaa ggtggaagaa ccatacttaa 454381 aggaatataa acaggaggtc aaagagtcgg gtgtaacctt aacaggtgac ttcgaagttg 454441 aggttccttc cggtaaatat tttgtgatgg gagataaccg tctcaattca ctggatagca 454501 gaaacggaat gggcatgcct tctgaggacg atatcatcgg tactgaatct ctcgtctttt 454561 atccattcgg tgagatgaga caggcaaaat aaaatgcaat gcaaaaagaa catggaacat 454621 gacggcaccg ataataaagc gccgtgcacg tttaaaaaaa tgatgatgaa acggtgcgga 454681 gccggctttc cgccccgttt tttatgatag aaagcgtttt gaagaaaagg gccctgttga 454741 aataaacaga atcaggattg gcgaagccgt gaagcgcatc gaattggtaa atctcaagat 454801 gggtatgctg tttttcccgc agttttttga taagaagcgc tacgtcaaac gacggctcat 454861 aattagggaa aaacaatagg accgggcagg ctggcatgtg atgaagagag tcgcgtatcc 454921 gggaaccgta ataacaaacc gatccgctca cctcaggcat actgctgcat ttccatgcga 454981 tagtagcccc cacgctgaat ccaatcacaa agatgtgccg tccggcgttt tgcctgatca 455041 cattctggat gatggtttct cccgttttca gcctttcgtg ttttgtaaat tgttcgtatg 455101 ccgttttttc ttctttcagt gtgtagactt catcctcgcc gagcaggttg ggcgtcaaca 455161 catcatatcc agccattttg atcagccggc ccatcttttt catatggctg tttacaccat 455221 atatttcgtg tgcgagaatg acaagcggtt ttgggaacat aacggcctcc ttttgtgttt 455281 tttccattat atcctatcgt ttcactttag gctgagatat aatggtcaaa aaaaggagat 455341 ataaaatgaa ctcattatct ttgcctcacc gctatccatt tttgtttatt gatggcgtga 455401 cggatagcga gcccggcaaa catgcggcag cttataagct gattagtgag aacgactggt 455461 ttatcactga tacgcaaaca gaaatgccgt tttcacttgt gattgaagcg cttgcgcaaa 455521 ccgcggcttt tacaggaatt acagatgaga acagcttggg attattgtct tcggtgaaga 455581 aagcggaaaa gctgggagaa gctgtgcctg gtgaccggct tgatcttacg tttgaagtca 455641 cgcgcaatcg gcgcgggttt gtgttcggac atgccaaggc atcagttgga gagcagcctg 455701 ttgctgaagc tgaaatcggc atctatattg aaaaatgaaa aaaacccttc acaacatttt 455761 gtgaggggtt ctattttgtg tcgtaatccc gttcgctttg agagttatct ctttgctggc 455821 gtttgtgttt ttcatcattc atattttcct tcagctcttc attaggaatc ggatcggtta 455881 agtcgttgtg ctcggggttt tcatttggtt tgttttgctg ttttttttct gtcatgtttg 455941 atcacctcac cgtttgtttt cctcttattc attctcctca aacataggaa atcgcttttt 456001 tgtcccgctg ggtataatgt attagaatag agagaagcac aacaaaaaga taaagagagg 456061 tacatatatg tctgttcaaa gagaagatgt agatatcaag ctgatcgcaa ttgatatgga 456121 tggtacactg ctgaacgacg agcagctgat ctcggatgaa aaccgcaaag ccattcgtga 456181 agcggaggat aaaggtgtgt atgtggtgat cagcacgggc cggacgctga tgacgtgcag 456241 ggagctggcg gaatcgctaa agctgtcatc ctttctaatc acggcaaacg gcagtgaaat 456301 ttgggattcg aattttaatt tggtggaacg gaagctgctt catacggacc atattcaaat 456361 gatgtgggat ttgcggaata agcacaacac taatttctgg gcttctacgg tgaataaagt 456421 atggagaggc gagtttccgg aaaacattac ggatcatgaa tggctcaaat tcggctttga 456481 catcgaggat gacgatatcc gaaacgaagt gcttgaggag ctgagaaaaa acaaagagct 456541 cgaaatcaca aattcaagtc cgacaaacat tgaagtcaac gcgcttggca tcaacaaagc 456601 tgcagccctt gccaaggtta cggaaaaact cggctttaca atggagaatg tgatggcgat 456661 gggcgacagc cttaatgaca ttgcgatgat caaagaagcg ggtcttggcg tcgcaatggg 456721 caatgcgcaa gacatcgtaa aagaaacggc tgattatatc acggatacaa atattgagga 456781 tggtgtcgct aaagcgattc gccattgggt actataaaaa aagagagtcc taagatggac 456841 tctctttttt agtttggcag gttttattct gggaccatgg taggttttct gacaaaagta 456901 tttcacaaac tgatatgatt cacttataat gaaataaagt tcaaaaattc ggaatagtcg 456961 ttccgaattt cgggacaata aatgacataa agcatatcgt ttgctttggc aggagggatt 457021 ctgtgtttca gattgattta aactgtgatt taggagaaag cttcggagcc tacaagatag 457081 gccttgacca agatatttta gagtatgtga catcagcgaa tatcgcatgc ggatttcatg 457141 caggagatcc tagtgttatg cgaaaaaccg tcgcgcttgc agcagaaaga ggcgtgaaaa 457201 tgggtgcgca tccgggcttg ccggatttac tcggttttgg gcgccgcaat atggcgattt 457261 ctcctgagga agcgtatgat cttgtcgttt atcaaattgg cgcgctctct ggctttctaa 457321 aagcagaggg acttcacatg cagcacgtca agccgcatgg cgctttatac aatatggcgg 457381 cagtcgatca aaaactgtcg gatgctatcg cgaaagctgt ctataaggtt gatcccggcc 457441 tgattctttt cggtcttgct gagagcgagc ttgtaaaagc gggagaacgg atcggacttc 457501 agaccgcaaa tgaagtgttc gccgacagaa cataccaatc ggacggcacg ctgacaccgc 457561 gctcccagcc ggacgcactc attgaaagtg atgatgccgc cgtcacccag gtcatcaaaa 457621 tggtgaaaga aggggcggtc aaatctcagc aaggacatga tgtgtcatta aaagcagata 457681 cagtctgcat tcatggagat ggagcccatg cgctgacatt tgcgcaaaaa atcagaaaac 457741 agctcaaagc ggctggaatt gaagtgacag ctatttcaga acagaggtca acataaagga 457801 ggaacaatag atggagcagc agaaaaagac agcaggaaaa aaagcgggca gctggtcatt 457861 gctgatgggc gccgcctttt taatggcgac atcagcaatc ggaccgggtt tcctcaccca 457921 aaccgcaaca ttcacaaaca cactcgcagc aagcttcggt tttgtcatct taatctctat 457981 tattttagat attttcgccc aaaccaatgt gtggcgcatc atcgcagttt ctggaaaacg 458041 aggtcaggaa attgcgaata tggtgcttcc cggactgggg tatttcatcg ccattctcgt 458101 cgtgcttggc ggactagctt ttaatattgg gaatatcgga ggggccgggc tgggacttca 458161 ggtgctgttc ggcattacac ctgaaacagg cgctttaatc agtgccgtta tcgccatttt 458221 gatttttgtc atcaaggaag caggaaaagc gatggaccgt tttacgcaaa tcgcggggtt 458281 cgtgatgatt attttaacgg tctacgttgc ggcgacgaca gctcctccgg tcggacaggc 458341 agtcgcaaat acattcgtcc cggaacacat cagcatattt gccattgtca ccctagtggg 458401 cggaaccgtc ggcggttata tcacatttgc cggaggacac cgtttgcttg atgccggaat 458461 taaaggaaag gaatccattc cgcaggtgac aaagagctcg gttgtcggca ttttaattac 458521 atctgtcatg cgtatcgctc tttttcttgc ggttctaggc gttgtatcga aaggcctgca 458581 catcgatgaa agcaacccgg cggcttctgt cttcaagctg gctgctggaa atgtcggtta 458641 taaaattttc ggattgatca tgtggtctgc ggcgattacg tctgttattg gagcagccta 458701 tacatctgtt tcatttttta aaaccttttc tccaaaaatt gaaaagaatt cacgcggtat 458761 tattatcgga tttattgtgg tttctacgtt agcttttgtc acaatcggcc agcctgcgaa 458821 gatcctcgtc cttgtcggtt cactgaacgg cttaattctg ccgattgcgc tcggaacgct 458881 gcttgttgcc gcctacaaga aaaacattgt cggtgattat aagcatccgc tttggctgac 458941 aagcacaggc gcgcttgtag tgattgtaat ggcagttatg ggaatctaca cgttatgtac 459001 acaacttcct caattgtgga gctgatataa gtggagcaat taaacaaaat ggcgccaaag 459061 gatgtacgcg ccctgatacg agaggggaaa ataaacgggc cgaccgcagg catgtccggc 459121 ggctacgccc aagcgaatct tgtggttttg aaaaaggacc ttgcgtttga ttttctgctg 459181 ttttgccagc gaaatcaaaa gccctgcccc gtgctggatg tgactgaagc aggttcgcct 459241 gtgccgtctc tggctgcgcc ggatgctgat atcagaacgg actttccgaa ataccgtatt 459301 tacaggcacg gtatcctaac ggaagaagta tctgatatta cgccatactg ggaggacgat 459361 tttgtcggct ttctgatcgg atgcagtttc tcctttgaac aggcactgat caataatggg 459421 atagctgtcc ggcatattga tgaggggaca aacgtctcaa tgtataaaac gaatatcgat 459481 tgtgttccgg cgggggcgtt tcacggacag atggttgtca gcatgaggcc ggttcctgaa 459541 cggctggctg tacgtgctgc acaagtgacc tcgcgttttc cggctgtgca cggagggccg 459601 atccatattg gcaatccggg agcaatcggg attcgcgatc tcgggaaacc ggatttcgga 459661 gatgccgttt ccattcgtga cggcgaggtt cctgtttttt gggcatgcgg agtgaccccg 459721 caagccgtgg ctatgaatgt aaagcctgaa atggtcatca cacatgcgcc ggggcatatg 459781 ctcatcacag atattcgaga cgagtcgctt gcggtgctgt agcctctcgt catcctgatg 459841 aacgagaatt aaaagaggtg agaaagatga ctgtacgata tcaaatcgaa cagctcggtg 459901 attctgcaat gatgatccga ttcggagaag aaatcaatga acaggtcaac ggcattgtcc 459961 atgcagcggc cgcttatata gaagaacagc catttccggg attcattgaa tgtatcccgg 460021 cttttacaag tctaaccgta ttttatgata tgtatgaagt gtacaagcat ttgcctcaag 460081 gcataagctc accttttgag agtgtcaagc gcgatgtcga agagcggctg gcagaaatag 460141 ccgaagacta tgaggtcaac cgccgtattg tagaaattcc cgtttgctat ggcggtgaat 460201 tcggtccgga tttagaagag gtggcgaaga tcaatcaact gtcaccggag gaagtaatcg 460261 acattcatac aaacggtgaa tatgtggtgt atatgcttgg cttcgcgccc ggttttcctt 460321 ttctaggcgg gatgtcaaaa cgcattgcag ctccgagaaa atcatcgcca agaccgtcga 460381 ttcccgcagg ttcggtcggt attgcgggat tgcagacagg cgtttatccg atttcaacgc 460441 cgggcggctg gcagctgatc ggcaaaacgc cgctggctct tttccggccg caggaaaacc 460501 cgccgacatt gctgcgggcg ggagatattg tgaaattcgt tcgcatctca gaaaaagact 460561 atcacgccta taaggaggag tccaattgag catgaaagta ttaaagcccg gactgctcac 460621 aacggttcag gatataggca gaacgggtta ccaaaaatac ggcgttctgg ccagcggcgc 460681 tatggacacg gtttcactgc gcattgccaa tctgttgata ggaaacggcg aaaatgaagc 460741 aggtctcgaa ataacgatga tggggcccgg tccgtcgttt catttttcaa aacagacact 460801 gattgctgtg acaggggcgg acttcacgct gcgtattaat gacgaggaag cgcctttatg 460861 gaagcctgtg ctcatcaagg aaaacagcac ggtcagcttt ggcccctgca aactcggcag 460921 ccgtgcttat ttggcggcag ctggcggcat tgaggtgcct gccgtcatgg aaagtaaaag 460981 cacatacgtc agaggaagca ttggcggact tcatggcaga gcgcttcaaa aagaagatga 461041 actgaacatt ggagagatgt cagctctttc gcaaaccatc ctttctcgct taagttcgca 461101 gcttggaaaa cagggatttg cagcaccgaa gtggtcagtc agccgcggca gatttctgcc 461161 attgaagaag aatcccgtca ttcgggtgct ggaaggaaag caatttgcct ttttcacaga 461221 agaatcaaaa acgcgttttt atgaagaagc atttcgtgtc acgccgcagt ccgaccgtat 461281 gggctacagg ctcaaaggag aaccgctcga actgaaggcc ccgcttgaga tggtgtcgga 461341 agcggtttca ttcggaacag ttcaggtgcc gcctgacggc aacccgatta tcctgcttgc 461401 agaccggcag acgactggcg gctatccgag gatcgcgcac atcatatccg ctgatcttcc 461461 gattgtttcc caaatcatgc cgggcgagca cgttcagttt gagcctgtgt ccctccagga 461521 ggcagaagcg cttgcggtag aacgggaaca gcatataaaa gaactgaaaa cgagaatgaa 461581 gatggaatgg ctgacatagc aaaggggatg aatgatgcag aataaaaata aaaccgtagt 461641 caaatctatg gcgctgctta atttgttttt gcataaacca agcctaacct taagtgaact 461701 ggtgtcgctg acgggaatgc cgaagacctc tgttcaccgg atggtcagct ccttggagga 461761 aatggggttc ctcagtcggg atgcgtccgg cgcttattcg ctgggattgg tgtttttgga 461821 attcggacag cttgtcgctg acaggctgga tatcagaaaa atagcgaaac cggtgatgga 461881 agagctgtgc cgggaagtgg atgaggccgt gcagttgatc atgagggacg gcaatgaagc 461941 gatatacgtt gagaaaatag aagggacaca gactgtgcgg ctgtatacgg cgatcggcag 462001 gcgttccccc ctatacgcgg gagcgtgcgc cagaagcatt ctgtcctttc ttccccgtga 462061 agaaatcgaa gcatacatca aacaaaccga gctcatttcg attggctccg gaacgattac 462121 cgatcccgaa aaactgcttc aggagattga tgcctctgtg caaaatggct atactgtcag 462181 ctattcagag ctcgaaaact atacggcggc gatcggcgcc ccgatcttta accatgagcg 462241 ccaggtggca gccggcatta gcattgcagg ctttgaagcg agatttacag aagacaggct 462301 gccctattta acagaaaagg tgaaggacgc cgctttacag atttcaagaa aaataggata 462361 tacataagta gccaatcttt tctctgctgc gtacattaac gtatcgacgt tcaagagtgg 462421 aggaaagaac atggtgcttc gatatacagc tctgggcgat tccttgacga cagggagagg 462481 ctccgggctg ttttcacccg gcttcgtcca gcgttttggg gacatgatgg aagctgactt 462541 gaaaacaaga acggcaataa acatatttgc cagatcaggt ctgaatacag aagagatttt 462601 gggactcctg tcatatccct atgtgcaaaa atgtattcga gatgctgata tgataacgat 462661 cacagggtgc ggaaacgatc tcatcgattc ggtcttagcc taccaaacct ctaaggatga 462721 aacgattttc agccgtgtat ccgcccattg ccatgagaat tttgaaaaga tgattgccaa 462781 agtcgccgag attaaaggag aaaatccttc cccgtacgcc attcgtgtgt tcaacttata 462841 caatccgttt cccgaaattg atatcgccgg caaatggatc acttcgttta attcacattt 462901 agaaacactt gcatcagcac cccatgtcaa aatcgcggat gcctatagca tcttcaaagg 462961 caaagaacag gaatatctgt cctttgacgg tgtccatccg aacagcaaag gctatcaagc 463021 gatggctgaa gccgttcaca agctaggcta taaagaatta tcagtttcat agaaaacgcg 463081 cctcatgaca ggcgcgtttt ttatgtgtga tcgaaatatt aaaagaaact taaaattctc 463141 tgtcttctgt tctacagaca aacaaagtgc gctagaataa tggagggcgt aggcaaatat 463201 agccataacg ttcaatattt cgtatataag gaaggatggt ccttttgttt cggattttta 463261 aaatgtcttt tgcggttatc attattatac tggcgcttat tgcttttaac tatacggaac 463321 acacctctgt aatccaatcg gtcatgctcg tctttcttgg tgcggtcatg tttatgcagg 463381 ggcttgaaga gcgcaaaaaa gaaaatgacg gctcaggcgc ttttaatatt tataccgccg 463441 tttttgtatg gtctgtctcc cttatcggtt ttacacttca tattatataa atctattaca 463501 catcctgaaa atgctcgacc gtcgggaacg gggtatagaa ccgatgaagc aaggctttcc 463561 actcttgata ctctgaagaa ccgcgaaagc cttccgtatg gtcctcaagt gtttcccact 463621 ccacaagaag cagatattta tgcgtttcct ccatgcattt tgataacgag tgagtgatat 463681 agcccttcat gccggaaata atcggcgcag cttgccggaa tgcatcctca aactcttgtt 463741 caaggccttc tttaatgtga agcattgctg cctctctgac catgctatcc cttctttctg 463801 tcttttcaaa tagtctacag caaacgatag gagatttctg caaaatcggt gaacttttcc 463861 ttcattttca aaaaaatctt gcacgcacca attcaattaa gagaaaataa caagtggaag 463921 gcaggggaaa gtcatgttaa aaaagtgtat tctactagta tttctatgcg tcggattgat 463981 tgggttaatc ggatgctcca aaacagattc accagaggat cgcatggaag cattcgtgaa 464041 acagtggaac gatcagcaat tcgatgacat gtatcaaagc ctgactaaag atgtcaaaaa 464101 agaaatctcc aaaaaagatt tcgtcaacag gtataaagcc atctatgagc aggccggcgt 464161 aaaaaatttg aaagtcactg cgggagaagt agataaggac gatcaagaca acaagacgat 464221 gaaacatatc ccgtataaag tcagcatgaa cacaaatgcc ggcaaagtca gcttcaagaa 464281 tactgctgtg ctgaaattag aaaaaacaga tgacgaggag tcatggaata tagattggga 464341 cccatcgttt attttcaagc agctggctga cgacaaaacc gtgcaaatta tgagcattga 464401 accgaaacga ggccaaattt acgataaaaa tggaaaaggc ttagccgtca atacagatgt 464461 tccggaaatt ggaattgttc ccggagagct tggcgataaa aaagagaaag tcataaaaga 464521 actcgccaaa aaacttgatt tgactgaaga cgacatcaag aaaaagctgg atcaaggctg 464581 ggtaaaagac gattcgtttg tgccgctcaa aaaggtcaag cctgaccagg agaaattagt 464641 ttctgaagcg acgtcattac aaggcgtaac aagaacgaat gtcagctccc gctactatcc 464701 gtatggcgaa aagacagccc atttgacagg ctatgtccgc gccattacag cggaagaact 464761 gaagaaaaag aaagaaggaa cgtacagcga tacgtctaac atcggtatcg ccggacttga 464821 aaatgtgtat gaagacaagc taagaggcac aactggctgg aaaatctacg tgccgcaaac 464881 cggggaagtc atcgctgaaa agaaagcaaa ggacggcgag gatcttcacc tcacaattga 464941 tatcaaaacg caaatgaagc tgtatgatga actgaaggat gacagcgggg cggcagtcgc 465001 gctgcagccg aagacaggcg aaacactcgc ccttgtcagc gcgccttcct acgatccaaa 465061 cggatttatt ttcggctgga gcgataagga atggaaaaag ctaaacaaag ataaaaacaa 465121 tccgttttca gcgaaattca ataagacata cgcgccaggt tctaccatta aaccgattgc 465181 ggctgctatt ggaatcaaaa acggcaccct taaagccgat gagaagaaaa caatcaaagg 465241 caaggagtgg caaaaagatt caagctgggg cggctattca gtgacacgtg tgtctgagag 465301 acttcaacaa gtcgatttgg aaaacgccct tattacgtca gacaatattt attttgccca 465361 gaatgcgctt gatatgggag cggacacctt tacaaaaggc ttgaagacat tcggtttttc 465421 agaggacgtt ccgtacgaat tcccgatcca gaaatcgtct attgcaaatg acaagcttga 465481 ttcagacatt ttgcttgcgg atacaggcta cggacaaggg caaatgcaaa tgtctccgct 465541 tcacttggca actgcttaca cgccatttgt tgacaatgga gaccttgtca aaccgacgct 465601 gatcaaaaaa gattcacaaa cagctgatgt ttggcacaag caagtggtca cgaaggaagg 465661 agcggcagac attacaaaag gtctgaaagg cgttgtggaa gatgagcgcg gatcagcgta 465721 tcagcctgtc gtgaaaggaa tcacagtggc tggaaaaaca ggaacagccg agctgaaaac 465781 atcaaaagat gataaagacg gcacggaaaa tggctggttt gtcggctacg attacgaaaa 465841 caaagacctg cttgtcgcca tgatgatcca aaatgtgcag gaccgcggcg gcagccacta 465901 tgtcgttgag aaagcgaaaa agcaatttca atcgaattaa aatgtctttt taaaaggagc 465961 gaaaggaaaa aggggatctg aggccgaatg aactagtaag ggggcaaaac ccggtttata 466021 caaagaaaag agggattttg catgcagcgt attcaattgg cggaggatct tcaattttca 466081 agagtcatac acgggctttg gcggctgaat gaatggaact attcagatgc tgaacttcta 466141 agcctcattg aatggtgtat cgatcacggc atcacgacct ttgatcatgc ggatatttat 466201 ggaggctata cgtgcgaaaa gctgtttgga aacgcccttg ccctttcgcc tggattaaga 466261 gaaaacatag agttggtcac aaaatgcggt atcgttcttg aatcgcctga acggcccgct 466321 cacagatcgc atcattataa cacaagcaaa tcgcatattt tggcatccgt tgagcaatcg 466381 cttatgaacc ttaggacgga ttatatcgat atgcttttga ttcacagacc ggacccgctc 466441 atggatccgg agggggtagc agaggcgttt caggccttga aatgctctgg caaggtcagg 466501 tactttggcg tttcaaattt taaagatcac cagtatcgga tgctggaatc atatttgcct 466561 gagaagctcg taaccaacca gattgagctt tccgcatacg aattagaaaa tatgctcgac 466621 ggcactttga acctgtgcca ggaaaaacgg attccgccga tggcttggtc gcctctggca 466681 ggcggcaaag tattcactga aaacacggat aaagaccgac gtgtccgtac ggcgcttgaa 466741 tccgtccaag gggaaatcgg cgccgcttca ttggacgagg tgatgtacgc atggctgtat 466801 acgcatccgg ccggcatcat gccgattgtc ggaagcggaa agcgcgagcg gatttccgcc 466861 gcgataaatg cgttgtcata caagcttgac caggatcaat ggttccgcat ttttacagcc 466921 gtacagggtt acgatattcc ataaaaagca tcagtttacc agctgatgct ttttcaatat 466981 tgtcacaccg cttagtgcca aattaccatt tataagtgat tgattctttc ttgaaagcgt 467041 tttatattaa aaggaaacct ctctatatcc tctactgcat ctccttgcga cttcatccgc 467101 acatcaagat tggctaggag gtctttttta tgtatatgac tgccagagaa caaaagctgt 467161 taaagcactt attattacaa aacagatata taaccgtaac tgagcttgct gagctgatgc 467221 aagtcagcac gagaaccatt cacagggaac tcaaatcaat taaaccgctg atggaaaccg 467281 tggggcttac gttagataaa cagcccggta aagggttgaa agcagtggga agtcccgagg 467341 gtaaacaaaa gctgcttact gatttatcat atgaacagca tgaatacagc gccgacgaac 467401 ggaaactgct cattctttgt tcgttattag agtctcagga gcccgtcaaa ctgtacacgc 467461 ttgctcatga tctccaggtg acgaatgcca cggtcagcta tgacttagat gagctcgaga 467521 agtggatttc tccctttgga ctgacactga tccgcaaaag aggttttggc atccagctca 467581 tagggccgga gaatgcgaaa cggaaaattg tcggcaactt gattgtgaac cgtctcgaca 467641 tccaaatgtt tttggaagcg gttgaattaa acatcaaagg aaaaaccgat tcttcagaga 467701 aaatgttcgg ggttgtcagc aaaggtgagc tgttaaaaat ggagcgcatc ttatttcagc 467761 tcaaagaaaa aatcgctttt tcattgtccg acagctccta tatagcgctc gtcgtccatc 467821 tgacgtatgc gatcgaacga attaagcttg gggaaactat caccatggag caaaatgagc 467881 ttgaggaact gatgaatgcg aaggaataca gctccgctct tgaaatcgcg ggcgagcttg 467941 aacgtgcctt cggcgtgacg attccagagg cggaggtcgg ctatattaca atccatcttc 468001 gaagcgccaa tcgaaaatac aaaacagaat acaaagcgca ggaaattgag ctggaaacag 468061 ccctgcaaac aaagcggctc attgctttta tttcagacaa aatcagaatg gatctgacga 468121 aaaactactc tttatatgaa ggcttgattg cccatttgga gccggccgtc agccgcataa 468181 aagaaaatat tgagatatac aatccgatga aggaacagat caagcgcgat tattttctgc 468241 tttatatggc gatcgaagaa ggtgtcgaaa agtattttcc gggcatgtcc ttttctgatg 468301 atgaaatcgc ttttatcgtt cttcactttg gctcggctct tgaaatcaaa aaagaagaag 468361 caaaagtgaa agcgcttgtc gtctgctcaa gcgggatcgg ctcctcgaaa atgcttgcct 468421 ccagactgaa aaaagagctg ccggaaattg aatcgtttga tatgtcatct ctgatcgagc 468481 taaaggggaa ggatgttcaa gcctatgata tgattgtgtc cactgtaccg attccttatg 468541 aaaacattga ttacatcatg gtcagcccac tattaaatga ggaagacgca aaccaggtca 468601 agcagtatat caagcggaag attcccctta ttcttaacaa aaaaagaagc tcgaaggaag 468661 aggcgcagca agctgatgta cctgacatgc tggaggcggc ggaaagcata gggcggtata 468721 tggaagttat ccaagatgtt ctgcgccatt ttacgctagc tcaactcaaa acaaacccgg 468781 accatagcat gcttctgcta gagctttttc aacagctgaa gaaggatggc ctgatccgtg 468841 atccggaaaa agccgcggtt tgcctggctg agcgggagaa acaaggggga ttgggaatcc 468901 ccggaacaaa catggcgctt tatcatctca aaaatgatga aatcgtcctg ccttttttca 468961 aaatgtttga tctcagcacc ccctatgaag tggatggcat ggacggaaat accctcagga 469021 tgacacgcat tctcgtcatg atggcgcctg gctcattatc tgctgaaggc tcggagattt 469081 taagcgcgat cagctcggca attatcgaga gcggagaaag catggcgggg tttcaggaag 469141 aaggaggaca agaattgtat cagcggttaa accgcatatt tttcacatgg atgaaagaaa 469201 aaaacatact gtaaacctgc atggcacacg tcaaaaattt ggcgtgtgtt tttctgtgga 469261 tggggaacaa aataagaaaa tgtgggacta ttttatcatt cagtattgga ataattccaa 469321 aatgaaatag ttttacaagt tatctttttt gggttaaaat gggtgaggta aggaagaaaa 469381 tctaacaaat tattgaagat tcaagagaat ataggagatg acgatatgga aacattacag 469441 catctgattc tgcatgacat gccgaatagc gaagaaatag aggctgtaaa aagcggagac 469501 catacactga catataaagg ttaccgtaaa cggattaatc agctggcgaa tgccatgctt 469561 caaaaaggaa ttcaaaaggg cgaccgtgtt gcattgcttt gcaaaaacgg ccatcccgcc 469621 tcaactgtta tgttcgccgc acttgaaata ggtgctgttg tcgtacctgt cagctggcag 469681 ctgaaaccat atgaaatgac aggcatttta aaagcaagtg aaccaaaagc gatgttttac 469741 ggagcggagt ttaaagagat actggatgaa gttcttcctg aattgtcctc actgtgtgta 469801 acaatggaaa caggaacagc ttacgaaaca tctgctgaat ttgaagcgct gtttgcaggt 469861 cctgatcatt tgccagagac ggaaatggtt tcacctgatg atacagcact tctgatgttt 469921 acatctggaa caacgggaaa cccgaaaaga tgcatgatta cacatggcgg catatacaga 469981 tacgttaaaa aatccaacag ctcaatagca cgtatgaagg gccttcgttt tctcgcgtgc 470041 catccgattt atcatacgag tgcgctcatt tgcatcatgc ttggaacgtt tgcagaaaca 470101 acatttgtgt ttacaaagga tcaagatcct gttcacatgc tgaaggtcat tgaagaagag 470161 aagattcaga ccgtgatggc tcttcctgtg ttctacacgt atttgcttga ggcgtgggaa 470221 aagcaccaaa ctgacttatc ttcgcttgtt attttaatga caggcggaac aaaagtgccg 470281 agcagcctaa taagccgcta tcttgatatt ggcattccgc ttgcgcatgg ctatggaagt 470341 actgaggctt ggggcatcag cacatggacg cctgatatgg gaatggataa agcggcatct 470401 gcaggaaaac ctgtggcagg tgttaaagtc aaagtggaag atcctctgac cggagaagaa 470461 cttcctcaag gagaaatcgg cgaaatcgtt gttcatactc cattcttatt taaaggctat 470521 gaagacaatc ctgaagcaac agcgaaagtg ctgcaaaatg gatggtttag aaccggagat 470581 tcaggatatg tagatgaaga tggctttatt ttcatcacgg gacgctacaa ggatgtcatt 470641 atttacggag gcgataacgt ctatcctgat caggttgaag aagttatcca gcagatcccg 470701 ggaatccttg aaacggctgt ggtcggtatt cctgacccgc tttacggtga aaaaccgaaa 470761 gcttttatcg tgaaaaatgg cggccagcgc atcacggaag aggatgtcat cgcattttgt 470821 aaagaacgcc tgtccgctta caaaatacct gaagttgaat ttgttaacga actgccgaaa 470881 aacaaccttg gcaaggtgaa aaaagacgtc ctgcgcaatc aggctgtaca ttcataaaag 470941 aagaagcccg tccactttat gtggcgggct tctttgcagt tgcacagacg gaaagctcag 471001 gcttaatgtt cttaaattgt atatcaatgt cttcgaagcc ggctgcttta aagtcagcaa 471061 tcatctgtct tccaaatgat ttggttttct caggactggc atccgcttcc cgcggctgca 471121 tcgtaatggc tgctttgccg cctggcttta atgcccgata aatctgtttt atgccttttg 471181 tttggtcatt ccaaatggtg tagttgttaa cggaaatcac tttatcataa aacgaggcgg 471241 ggagaggaaa tgtctcgatg cttccttgta tcaggcgtac gccctttggt ttcactctgc 471301 gggcggccag cttcagcatg gcctctgata catcaatccc atgaagatga acatccttct 471361 cgcgtttcag catctgctgc atgcagtatc ccgggccaaa cccgacttct aaaatgctgt 471421 ccccgcgcgt gatacccagc tgattgattg tccactgatt cagtgtttga ttttcagcag 471481 ccatgatgta cccggcaatc atgccgatga cgccctttgg cctgctgaat cttctagaaa 471541 gcatgttaat cattcagcaa ccaaccccct ttttgagtta atttcctctc agcgttccat 471601 gtgaaacatt tttctgataa agcaatgcga aggtgccaag ccatgtttat ccaaagagtg 471661 tgtgaggtac acaacaaata gacatgaaaa caaaggagga gaatcatcat ggcaaattat 471721 ccaaaagaac tgccggcaca aactcaaagt cgccagccgg gaattgaaag cgaaatgaat 471781 ccaagtccgg tgtatgagta cgaggattat aaaggagcag acaaattaaa aggaaaagta 471841 gctcttatta caggcggcga cagcgggatc ggacgcgcgg tttccgtcgc ttacgcaaag 471901 gaaggcgcag acatcgccat tgtgtataag gatgagcatg aagacgctga ggagacgaag 471961 aaacgtgttg aacaagaagg cgtaaaatgc ctgctgattg ctggtgacgt aggtgaagag 472021 gaattctgca atgaagcggt tgaaaaaacg gtcaaggaac taggcggcct tgacatcctt 472081 gtcaacaatg caggtgaaca gcacccgaag gaaagcatca aagatattac gagcgaacag 472141 cttcaccgca cattcaaaac aaatttttat tctcaatttt atttgactaa aaaagcaatt 472201 gattacctga aaccgggcag cgccatcatc aatacgacat ccatcaaccc gtacgtaggg 472261 aacccgacac tgattgatta tacagcgaca aaaggggcga tcaatgcctt tacaagaaca 472321 atggcgcagg cgcttgtcaa agacggcatc cgtgtaaatg cagtcgcgcc gggtccaatt 472381 tggacgccac taatcccagc tacgttccct gaagaaacag ttgctcaatt tgggcaagat 472441 acgccgatgg gccgtcctgg acagcctgtt gagcacgtcg gctgttatgt gcttctggca 472501 tcagatgagt cctcttacat gacaggtcag accctgcatg tcaacggcgg aaactttgtg 472561 acgacataag agggagtgag acatatgggc atcacgaaag aagaagtgaa cagctactat 472621 caaaaagcag ggattgtatt aacggacgag gaagtagacc aaatccagct gatggattac 472681 ggcttaggaa aagaaagaaa agtcgggctc cagctcttcg tctacgtcaa tacagaccgt 472741 tattgttcaa aggaattggt gctgtttccg ggacagactt gcccggaaca ccgccatcca 472801 ccggtcgacg gccaggaagg caagcaggag accttccgct gccgctacgg aaaagtgtat 472861 ctttacgtag aaggagaaaa aacgccgctt ccaaaagttc tccctcctca ggaagacaga 472921 gaacactata cggtctggca cgaaattgag ctagaaccgg gcgggcaata cacgattcca 472981 ccaaacacaa agcattggtt ccaggccggg gaagaaggtg ccgtcgtgac ggaaatgtca 473041 tcgacgagca cggataaaca tgatatcttt accgatccaa gaatataagg atgggcttaa 473101 cagcccatcc tttttgtatt gaaaaaaaca gaatcatcgc tataatgggt aaaaaaggaa 473161 agagggcgag gcaatgttca cttgcaaggt aaatgagcac atcaccatcc gattattgga 473221 gccgaaggat gcggagcggc tggccgaact cattatccaa aatcagcagc ggcttggcaa 473281 gtggctgttt tttgcggaaa atccaagcag cgctgacacg taccgagaaa caatcattcc 473341 agattggcgg cgccagtatg ccgacctgaa cggcattgag gcgggtctcc tttatgacgg 473401 cagcctatgc ggcatgatca gcctgcataa ccttgatcaa gtgaatcgta aggcggaaat 473461 cggatattgg attgccaaag aatttgaagg gaaaggcatt attacagctg cctgccgaaa 473521 actcattacg tatgcttttg aagagcttga gctgaatcgt gtggcgatct gtgcggctgt 473581 cggaaacgaa aaaagcagag cggttccgga gcggatcggg tttctagagg aaggaaaggc 473641 acgggatggc ttatacgtaa acggcatgca tcacgacctc gtctactaca gtctgttaaa 473701 gcgtgaatgg gaaggcgaaa aataaagagc acactttctt gtttaaatct tccccggatg 473761 tggaaaagta acagcggaga cgttaaaaag gagtgattcg agatgaatca gcaagacatt 473821 aaacaaaaag tgcttgatgt tctagatcac cataaagtag gttcgctcgc aacagttcaa 473881 aagggcaaac cgcattcccg ctacatgact tttttccatg acgggctgac gatttacaca 473941 ccgacaagca aggaaactca taaagcggaa gaaattgaga acaaccccaa tgtccacatt 474001 ttattaggct atgattgtga aggttttggc gacgcatatg tcgaagttgc cggaaaagca 474061 aagatcaaca attcggcaga actcaaggac aaaatatgga gttccaaatt agagcgctgg 474121 tttgacggca aggatgatcc gaatctggtg attcttgaaa ttgaaccgga ggatatcaga 474181 ttaatgaatg ccggggagaa aacaccggtc tcactcgaac tataaaaaat ttgtgttttc 474241 aggggcgata tgttattatg aatagctagt aagaaaaata agcaaataaa aaagaaagta 474301 aacttctttt ttctgttttg agagagaagc ttaccgcttc ccaagcagca taaccagctg 474361 cccttattct tttccttcat aacaaatcgc ccctaacgat gagatggaaa aaagactttt 474421 ttgttttaca attcacaccg gcgcggcttc ggagccgcag tgacgattga gaggtagggc 474481 tttcgttgtc ttgtgttcaa gaaatttcca tggtgtttac tttccagaat gattcttcgg 474541 aacaatgctt tatgaatcta acccgcctga cttggcggat gatataatct ttatttgcgt 474601 atagaaaaga ataagacaaa ccgcccggcg tacgccggac ggttttttta ttgcaaaaaa 474661 cacatcgtac tgaaacctcc ttgtcttctt tccagtctta tctctaggat gaaattggag 474721 gaagaataac gtgcatgtca ttacaacaca agtacttttt attttttgtt ttttattgct 474781 gattcactcg atagaaacct tagcctatgc gacaaggctt tccggagctc gcgttggatt 474841 tattgcgtcc gcgctttctc tgtttaatgt catggtcatc gtatccagaa tgtcgaatat 474901 ggtgcagcag ccctttactg ggcatttaat tgatgatgct ggaaaaaacg cactggcgat 474961 tgtaggggag cagttccgct ttttaatttt cggatcgaca gtcggcacca ttttgggcat 475021 tatcctgctc ccgtcttttg tcgctctttt ttcacgggcg attattcact tggcgggcgg 475081 cggcggctcc gtttttcaag tattccgaaa gggattctcg aaacaaggat tcaaaaatgc 475141 cctttcctat ttgcgtctgc cgtccatttc atatgtaaaa ggatttcata tgcgcttgat 475201 tccgaagcgt ttgtttgtca tcaacatgct gatcacatcg atttatacga ttggtgtgct 475261 ttcggcttta tacgcaggcc ttttggcgcc ggagcgcagc acgacagccg tcatggcttc 475321 gggtttgatc aacggaattg caacgatgct gctggctatt tttgttgatc ctaaggtatc 475381 cgttcttgct gatgatgtgg caaaaggaaa acgaagctat atctatttaa aatggacctc 475441 tgtcacaatg gtcacatcaa gggtggcggg cacactcctc gcccagctca tgtttattcc 475501 cggggcctac tatatcgcgt ggctgacaaa gtggttttaa taagaaaggc tggatcataa 475561 agatccagcc tttttgcgct tccttattta tagttcctta atccgcggtc gtacaaaaaa 475621 tttccgaatg ggacgaaagc ggcgatgaag ccggcagctg accatttcag cggccatttg 475681 acagagaagg ttgcataagc caagacaagc aaatacaaaa tgaacaaccc gccgtgaacc 475741 gaaccgacaa ttgtcaccgc aagcggaagg cctgcccaat atttaagcgg catagcgatg 475801 aacaacagga ttaagagtga cattccttca ataaaaccca tcgtgcgaag tcttccgatc 475861 ggcgtgtgca gcataaatcg ccctccttgt ggacacgttt tcattttata ctataaacaa 475921 tccggggggg catatgacag ctttcaaaaa atgttcggaa aacattcatt tttacatgcc 475981 ttttctaggg aactgtactt gtcatttaca aaaatacccg agataatgtg tacaaaatca 476041 aaaaagaagg atgttgaaat gaaacttgac cagattgatc tgaatatcat tgaggagctg 476101 aagaaggaca gccgtttgtc gatgagggaa ttaggcagaa aaattaagct gtcgcctcca 476161 tctgtaacag aacgggtaag acagcttgaa tcgtttggca tcatcaagca atacacgctg 476221 gaggtcgacc agaaaaaact ggggcttccc gtttcctgca ttgtggaagc aaccgttaaa 476281 aacgcggatt atgagcggtt caaaagctat attcaaacat tgccgaatat tgaattttgc 476341 taccggattg cgggtgcagc ctgctatatg ctgaaaatca atgccgaaag cctcgaagcg 476401 gtagaagatt tcattaacaa aacatcgccc tacgcgcaaa ccgtcactca cgtcattttc 476461 tcagaaattg acacgaaaaa cgggcgcggt tagagagtgc cgcgcgaagt ctgttataat 476521 aacaggatga gcgtgaaaga aagagaagtg atcaagcatg tcaaaaacag ttgtattagc 476581 tgaaaaacct tcagtcggcc gggatttagc ccgggtactg aagtgccata aaaaaggaaa 476641 cggttatctc gaaggcgatc aatatattgt gacttgggct ttaggccatt tggtgacgct 476701 tgctgatccg gaaggctacg gaaaagaatt tcaatcatgg cgcctagagg atctgccgat 476761 tatcccagaa cccttgaagc ttgtggtgat aaaaaaaacc ggaaagcagt tcaatgcagt 476821 caaatcccag cttacccgta aagacgtcaa tcagattgtc atcgcgactg acgcaggccg 476881 ggaaggtgag cttgttgcgc gctggatcat tgagaaagcg aatgtccgaa aaccaatcaa 476941 gcggctgtgg atttcatctg tgacggataa agcgatcaag gaaggttttc aaaagctgcg 477001 cagcggcaaa gaatatgaaa acctgtacca ttctgccgtc gccagagcgg aagcggattg 477061 gattgtgggg atcaacgcca cccgtgcact taccacaaaa ttcaatgccc agctctcatg 477121 cgggcgtgtg cagactccga cgcttgccat gattgcaaag cgcgaggcag acattcaggc 477181 gtttacgccc gttccgtatt acggcatacg tgctgcagtc gacggcatga cgctgacgtg 477241 gcaggataag aaatcaaagc agacgagaac gttcaatcaa gatgtaacaa gccgtttgct 477301 aaaaaatctc caaggaaagc aagcggtcgt agctgagctg aaaaaaacag cgaaaaaaag 477361 ctttgcgcct gcgctttatg atttaacgga gctccagcgt gacgcccaca agcgcttcgg 477421 tttttctgcc aaagaaacgc tttctgtcct gcagaagcta tatgagcagc ataagctcgt 477481 cacatatccg cggacggact ctagattttt atccagtgac atcgtcccga cgttaaaaga 477541 ccgtctggaa ggcatggaag taaaaccgta tgcccaatat gtcagccaaa ttaaaaaacg 477601 cggcattaaa tctcataaag gatatgtcaa tgacgcgaag gtgtcagacc accacgcgat 477661 tatcccgacc gaagagccgc tcgttctcag cagtctgagt gataaagaac gaaagctgta 477721 tgacctgatt gcgaaacgtt tcctggctgt attaatgcct gcattcgaat atgaggaaac 477781 aaaggtcatc gcagaaatcg gcggagaaac ctttacggcg aaaggcaaaa ccgtgcagtc 477841 gcaagggtgg aaagccgttt atgatatggc ggaagaggat gatgagcagg aggatgacag 477901 agatcagaca cttcctgcgc ttcaaaaagg cgacacactt gccgtccgca cgttaacgga 477961 aacaagcggc caaacgaagc cgcctgcccg ctttaatgaa gggaccttgc tgtcagcgat 478021 ggaaaaccca agcgcgttta tgcagggaga agaaaaaggc ctcgtcaaaa cgcttggaga 478081 aacaggcggc ctcggcacgg tggcaacgcg tgccgacatt attgaaaaac tgttcaacag 478141 ctttttaatc gagaaaaaag gccaagatat ttttatcaca tctaaaggaa aacagctcct 478201 gcagcttgtt ccggaggatc tgaaatcacc ggccttaaca gcagaatggg agcaaaagct 478261 gtctgcgatc gcggccggca aattgaaatc ggctgttttt attaaagata tgaaggctta 478321 cgctcaccaa acggtaaaag aaatcaaaaa cagcagccaa accttccgac atgacaacat 478381 tacgggaacg gcatgtccgg aatgcggcaa aatgatgctg aaagtaaacg gcaaacgcgg 478441 gacgatgctc gtgtgccaag atcgtgaatg cggaagcaga aaaacgattg cccgaaaaac 478501 aaacgcacgc tgcccaaatt gccataaaag aatggagctt cgcggccaag gcgagggcca 478561 aacctttgcg tgtgtgtgcg gtcaccgtga aaagctctct gtatttgaaa aacgaaaaaa 478621 caaagacaaa gcgcgtgcta ccaaacggga cgtatcctct tatatgaaaa aacaaaataa 478681 agatgagccg attaacaacg cgctggcaga acagctgaaa aaactcggtt tggataaata 478741 ataaaaaaac ctgtgcctat cgcacaggtt ttttattgga cttaggtcct gttttcttaa 478801 tgttcaaaaa gggaaaaaaa agctagcaat ctgcattttt tttcttttat agtaaatgta 478861 ctttgtaaca tggcagtcat attttcgtct ataactattt gtgagcgtct gatttgcttc 478921 aggcgacaaa gggggatttg cctgtgaggc atgtactaat tgctgtcatc ttattcttct 478981 tatctatcgg actttccgca gggtgtgctg aagctggaaa caagacccaa aatcagtcgg 479041 cgacagaagt gaatgccagc ccgctccagc cggcggaata tttcatctat cacaatttaa 479101 tgaatgacaa agggctgatc aaaaccgatt tttcagacca gccttcttac ttgtcggaat 479161 ctctcggact gtggatggag tttctgctca gcaaaaatga cgcaccacat ttccaggatc 479221 aatatcagca tctgactgat tcatttctga tgagcaatca cttggtgacg tggaagattc 479281 aaaatggcca agcgagcggg acgaatgcgc tgatagatga tatgagaatt atgctgtctc 479341 ttgaccaagc cgccgcaaaa tggggccgca gcgactacgc gcaaacggct agggatatcg 479401 gcacgtcttt gaagacatac aatatgaaca acgggttttt tacagacttt tacgactcac 479461 aggccgcttc aaaggatgtg acgctttcat acgtcatgcc tgatgcctta gctgtcttaa 479521 agaagaatgg aatcatagac gaagaaacag aacagcggaa tgccaatgtt ctctattcag 479581 ctcctttaaa aaatggcttt ctgccgaaga catacagctc ggagacgaag gaatacacat 479641 atgatagtga aatcaacctg attgatcagc tttacgctgc ttggcatttg ccggaagggg 479701 atgaaaaagc atctgtttta gcggactgga tcaagcagga atttcagaaa aacggaaagc 479761 tgtacgggcg gtattcggca tatacgaagg agcctgccgt ccaatatgag tctccatccg 479821 tatatgcctt agccgtattg tttttgacaa aacagcatga aaacagttct gtcatcaaag 479881 ccatatatga tagaatgaat gactttgaaa ttcatgatcc ggtgaaatcg tattatggag 479941 gctatatgag cggcactcag acgcattcat ttgacaatct gctgccgctg ttagccgaaa 480001 ggaagctttt taatgaaaat atcattcagt gaatcacaaa aattatttgc ttatttttca 480061 gggctcatcg cggccctgtc tttgtttatt tattatgtgt cagcccagca atcagaaggt 480121 gctctgatcc tttgcatcac atttggcgtc atcgccgcag gcatctggtt cggcccgatt 480181 tacgcgctgg cagtgacctt aatcgtactc tttgttctcg gcaccttaat gatgtttttc 480241 cagactggac agacatcgct ctttccggct gaggaagggc tgcgaatgct tgtcgtgtgg 480301 ggaatcgcgc ttttgctgtt ttcttttatt tctggaagaa tccacgatat tacagcagag 480361 cttcggcgct caatgacacg gcttcaatcc gaaattaaaa gctatgttgc tgttgacaga 480421 gtgactggtt ttgataacaa gcaaaggatg aagctggaac tttcagaaga aatcaagcgg 480481 gcggagcgct acggcaattc ttttgtgttt ttgctgctcc atatgcatta tttcaaagag 480541 tttaagtctt tgtacggtga aaaagaaacg gaccgcctct tccaatatgt cggtcagcaa 480601 atcaggacaa gcgttcggga aacggataag aaattccgtc cctctgacga gcgtatcggg 480661 atcgtgctga cgcacacgcc tgctgaacat atgccggccg ttctgactaa gctgaagaaa 480721 caattggata catatcagct ggaaaatgga aagtatgtgt cgcttacgtt ccacgtttgc 480781 tatttgccct accgcaacga tatccaaaca gctgatcaat ttttagaaga actggaaaac 480841 gagatgatga tgaatgaact ataaaggaat cacattgcta tgcgtcatga tgcttctatt 480901 ttcagctatt gcgtcttttc ccgtttctgc gcaagcgaaa gatcaggatg ccggcattct 480961 catcatctac tcaaccttgg acggcaaaga gtcgtcacaa gtcaaaatgc tcgatttgct 481021 tgcgggccac tttacatccc atgtgacagt caaaaaagat tcagacgttg aagcgtcgga 481081 tttcaaaggg aaagaccatg tgatttatta cggccaaacg aaaagaaagc tcagccaaaa 481141 attgctgtct cttatcagcg gcgtgaaaaa accggttgtc gccattggct ataacgcagg 481201 ccaaatcagc caattttctg ggctttcatt agcccgcaaa gaaaatgtgt ttcaggttca 481261 cagcaggtca gaaaaggccg atgtgtctct ggaaagcggg cttaacgtgc tgagtgtatc 481321 aggcctgaaa ggaacggcgc tttacacctt caaagcggat gaaggcacaa cgcattcttt 481381 tatatggaaa acaaaaaaag ggaatgtgta cattggatta acaaatttgt taaatgacaa 481441 tttgatcgtg gcgaaacagc tcagagaagc tttcggagag aaggcgggga cgacgttatt 481501 gtatttgcgt ctcgaggata tcagcccgat gtctgatgaa aaactgctgc ttcaagccgg 481561 tacatacctg cataagcggc atattccttt tatcctggcg gtcattccgg tttacttgaa 481621 tccggaaaca ggcgacaaag tgtatttgtc taatcaaccg aagatggtca aggtgctgaa 481681 gaagctgcaa agcatgggcg gcagtatcat agttcacggc tatactcacg cttatcgcta 481741 cagtgaaaca ggagagggat ttgaattttg ggatgcaaag gcggatcagc cgattacatc 481801 cggaaatgcc gaagaccccc cgtccatttt ggagaaagaa caggacttcc cgaacgaaca 481861 agcctatcac agctatcttg aaccatttcg ggaaaaggaa gaaacgtata caaaacaaaa 481921 actgacgcgt gccattgagg atttgacatc atcgggtctt tacccgctgg cgtttgaagc 481981 gccgcattac acgatgtccg aatatggcta tcaaatcgcc tcgcagtatt ttacaagcat 482041 tttcggccag gtccagctca gcagcacaac atggaaaaca tccggtgcac ctccgtttgt 482101 gactgctcct tcgatgctgc acggaatgac gctttatccg gaaacgatcg gctttgtcga 482161 cacatcgaag caaaacccgc tcggtgagat ggaggagcat atctcccaga tgattgattt 482221 tgaaggcgga gtagccggag gattttatca cccgtacctt gggatgaaat atctgcctga 482281 gctggttgat cagatggaac gcattccaga cagtgaatgg cttgatttaa agaaaacgaa 482341 acaaaccgtc aaaacagaca aagtggaaat tcatacaagc ggtgacggaa cgattcaggt 482401 gaaaaacggc gtaagcccca tttacgagtt tttcgatcat caccggcaaa cccctctgga 482461 aaaggcgtta tggattctct ccgctgttgt gctcttattt gtcatcatgt ttgtcagtta 482521 tacgttttac ttgagagcca cattgaaaaa acgaattttt aaggagagaa gaagccttgg 482581 gtaatacgct gttctttatc tcgctaagtt taatatgggt tatgcttctc taccacatgt 482641 tcctcatgca gggcgggttt cgccactata tgaccttcga acggaatatc ccgaagtgga 482701 gagaaaatat gaaggaactg ccgaaggtca gcgtcctcat cccggcgcat aacgaagagg 482761 ttgtgattcg gcagacgctg aaggccatgg tcaaccttta ttatccgaag gaccggctgg 482821 agattatcgt cgttaatgat aattcatcag accggacggg tgatatcgtc aatgaatttt 482881 ccgagaaata cgatttcatc aaaatggtga ttacgaagcc gccaaatgca ggaaaaggaa 482941 aatcctctgc acttaactcg ggttttgccg aatcgaacgg cgatgtgatc tgtgtgtatg 483001 acgccgacaa cacgcctgag aaaatggccg tgtattacct cgtgctcggc ctgatgaatg 483061 acgaaaaggc aggcgccgtg gtagggaaat tccgcgtcat caatgcggca aagacgctgc 483121 tgacgaggtt tattaatatc gaaacgatct gttttcagtg gatggcccag ggaggcagat 483181 ggaagtggtt caaaatcgcc acgatcccag gcaccaactt cgcgatccgc agaagcatta 483241 tcgaaaagct cggaggctgg gatgacaaag cgctcgctga ggatactgag ctgaccatcc 483301 gggtatataa tctcggctat cacatccgct ttttccctgc cgccatcacg tgggagcagg 483361 aaccggaaac atggaaggta tggtggcgcc agcgcacccg atgggcgcgc ggcaatcaat 483421 atgtcgtgct caaatttttg gcgcagtttt ttaagctgaa acgaaaacgg attatctttg 483481 atttgtttta ttttttcttt acgtacttcc tgtttttctt tggcgtgatc atgtcaaatg 483541 cgatttttgt agtgaatttg ttttatgatt tgcatttgtc tgttggattt ttggcaatga 483601 ttctctggat tttggcgttt ttcttattta tgacagaggt catgattacg ttgagcattg 483661 aaaaaacaga aatgaacaag caaaactttt ttatcgtatt tctcatgtac ttcacatact 483721 cgcaggcatg gattgtgctt gttatctact ctttattcgt agaaatcaag caccgtttat 483781 tcaagcaaga ggtcaaatgg tacaagacag aacgatacaa tcaacataaa agcgggtgac 483841 ctttttgaaa caaataatga tttttctcac aagcttcatg ctgctggcga tgactggaca 483901 aacggctctt gccaaagacg tacaggtcag cggttcgctc cttgggaaaa gcagccaaga 483961 acaagccaaa cagcaggtgc tgacaagcga gctgattaca ctgtatggat caaaagacag 484021 cgcagagctg acgtatcaga tcccggcagg cgcctcttcg ggcaatcagc aattggtaat 484081 cgaatacgag gcatcaaatc ttttaatttc tccatcatcg ttaacggttg tcattgatga 484141 tgaaccggtc aagacgttaa agcttgatgg tgattccaaa cggaaaacag tgaagctgaa 484201 tctgaataaa agccagtctg cgcaaggcta tcacaacgta tcgctgaaat tctacggcgt 484261 aatgaaagag ggcgtgtgcg tcagacagga tacatcaggc aactggatca aaatttatcc 484321 ggacagccgg ctgacacttg ctgacagcag tgaagcgaag ggaacgtcgc tggaccatta 484381 tccgtatcct ttcgcccaat ctggaaatac agcggaagaa acagctatcg tcattccgga 484441 taacccaagt tcagcagaaa tagaagctgc tgttaaaaca gaaggctatt tgaaaacggt 484501 ggacagcagt gtcagtattg cgtatgtcac ggaatctgaa ctgaaaaaaa tcgataagcc 484561 gacgattgtt atcggcgtgg acaagcattg gaacggcaaa gtgaaaaaac tgttgaaaca 484621 agccgggcta caggcaaaag gagaaaacct tctgcttgcg gagcgggtgc tgaaagcaga 484681 gggcaaacag cagccggttc tgtttgcgca agcggcgtcc gaggacgcgc tcacaaaaaa 484741 aatcagcgtg atgacagatc agacatatac aggccagctc agcggcgata cactttcaat 484801 cagcaagctt cagcagactg aaaaaaaaga aagcgataag ctgacccttg agaattttgg 484861 agcgggtgat atcacaattg gagccgacaa aacatcttca gcacattatt tttatccggc 484921 ttcggctgtt ttagatgaaa accaatcggc gaagctgtcg cttaaactga aaaagtctga 484981 aacgattcaa gcctcaacgg ctgaaaacga gtcagcctct caggctgcag aactgaaagt 485041 gatgatcaac ggccagccgc actcggtccg gcttgatgaa ttaggaaaag aagataaaaa 485101 cggattctat catgtcacag tgaaagtgga ccctaagctg ctgcaaaaaa accgctacat 485161 tgatattcag ttcgtcacga ccggtttaaa ggaaaacaac ccttgtaaca ccactgatga 485221 agaaaagtgg gtttttatcg ataaaaacag tacattatca tacgccatca aaggcatgtc 485281 cccgtcagcg gattttcaag agtggccgct gccttacgcc ggaaaccagg atcaaacaac 485341 gttaatcgtg cttcctgaca ccgtaagcca atcgaagcta gaggagcttt ctctcgtaac 485401 agaatccttt ggcaacgaag cacagcattc atatacggta aagaaatcat ctgacgttac 485461 agcaaatgat gcgaaaggac gaaacctcat tttcatagga gggatcaatc aattttctct 485521 tctgaaggag aaatcatcag atctgcttgt gccgcaggaa aagaacggct cgtttgatgt 485581 atctagtttc gagatgctga atgagacgac aaaacaagtg gtatttaccc aagcatcggt 485641 ttgggattca cgctatacaa tggctgtctt tgcaccgtca aaaggagatg gcacggctgt 485701 cacaaaagag atcatcagtt atctgaacag caacgatgag tcggcaaccg tccttaatga 485761 aacaaacagc cagcaggtgt ttacaaacca ccagcagctc aaatcggaaa caaacagttc 485821 cgatgcagaa caaccaacac aggatcatag ccagaaatgg atgtatattg gtgtgctggc 485881 actcattatg gtggttgcgg cagtgttcat ttggattgcc gtaagacgca aaaaaagaaa 485941 gacagataca gaataaaaca gaggcgattt tagcctctgt ttttttattt ttggtaagta 486001 aattccattt gtggaacctg tcattttatt tttttctctc agccaataag cctctttaca 486061 acgtgcggga acgggagtat gatctctttt agaaaacaaa tcgcttaatc tgaaatcaga 486121 gcgggggacc caatagaacg gctttttgcc gttggggtga atccttttta ggtagggcta 486181 actctcatat gcccgaatcc gtcagctaac ctcgtaagcg ttcgtgagag gagatgaatg 486241 aaacctgtgt tcgatgttat ggcacagggg catccgtttg cctctgtgtt ttttgttgtt 486301 catttttgaa tgcaaatcgc atacagagac atcatagcag aaaggactat catcaacatg 486361 tgagagcaag acactgatgg atgttttatt gttttaattg aaaaatgaga aattaaaagg 486421 ggaagacatc gatgtatcat tcaatcaaac gttttttgat tgggaaacca ctaaaatccc 486481 aagcagctgg agagcaaaaa ctgacgaaat taaaagcctt ggctatgctt tcctcagatg 486541 cgctgtcatc tgtcgcatat gggacagaac aaattctaat cattttggca acaatcagtg 486601 cagccgcatt ttggtactcc attccgattg cggttggcgt tctcatcttg ctgctcgcac 486661 tgattctttc atacaggcaa attatttacg cttatccgca gggcggcggg gcgtatatcg 486721 tttctaaaga aaatctcggt gaaaaaccgg gattgattgc gggcggttca ttgcttgttg 486781 attatatttt aacagtagcg gtaagtattt ccgcaggcac ggatgccatc acgtcagcct 486841 ttcctgcatt gcatgattat catgtgccga tcgctatttt tctcgtgtta gtgattatga 486901 ttttgaacct gcgcgggctt tcggaatcag catccatact tgcctacccg gtttatctgt 486961 ttgtggtggc gcttttggtt ctcattgcag tcgggttgtt taaacttatg acaggacaaa 487021 tagaccagcc agcccatcat acatcgctcg gcacacctgt agccggcatt acgctatttt 487081 tgctgcttaa ggctttttcc tccggatgct cagcgttgac cggggttgag gccatttcta 487141 atgcgattcc tgcattcaaa aacccgcctg cgcgaaacgc ggcaagaacg cttgcgatga 487201 tggggatttt gctggcgatt ctgttttccg gcatcacggt tctcgcgtac gggtatggta 487261 cggcgccgaa acctgatgaa acagtggttt cacaaattgc gtccgaaacc tttgggcgga 487321 atgtgttcta ctatgtcatc caaggtgtca catcgcttat tttggttctt gcggcaaata 487381 cgggattctc agccttcccg cagcttgcct tcaacctggc gagagaccag tatatgccgc 487441 gaatgtttac agtcaggggc gaccgcttag gcttctcaaa tgggattatc tttttaggct 487501 ttgcctccat tgttctcatt atcttattcg ggggacagac ggagcactta atcccgttat 487561 atgctgtggg cgtatttatt ccatttacgc tttcacaaac cggcatgtgc atgaaatgga 487621 tcaagcaaaa accaaaaggc tggatcggaa aaatgctgat caactcctgc ggcgctctga 487681 tatcatttat ggttctatcc attctgtttg tgacgaagtt taatgtcgta tggcctgtgt 487741 taatctttat gcctatcgtc gttttgctgt tttttgcgat taaaaatcac tatactgcgg 487801 ttggtgaaca gcttcgcatc gtagacaaag agccggaaga aatcaaaggc accgttgtga 487861 ttgtgcctgt ggccggtgtc accaccgtcg tgcaaaaatc gattcactat gcgaaatcac 487921 tgtccgatca ggtgatcgcc gttcacgtgt catttgacag agaacaggaa aagaaattcg 487981 aaaaacgttg ggaagagctt aataacggag tgcgtctcgt gacgcttcac tcctcttaca 488041 gaagccttgt ccatccgttt gataagtttt tggaaacagt tgaggcaaaa gcgaagaagg 488101 agcagttttc cgttatggtg ctgtttccgc aatttataac gaaaaaacgc tggcacacca 488161 tccttcacaa ccaatcggcc ttcctcctca gagtccggct gttctggaaa aaggacataa 488221 tggttgccac actgccgtat cattttaaaa agtaaagctc taggaccaag ggaatcacct 488281 tggtcctttt tagcgggaaa aggaggtatg ggggtgtata cacaaggtgc ttttgtgatc 488341 gtattgaacg aaagtcagca aattctgctg gtgaaacgaa aagatgtccc tctatgggat 488401 ttgccgggcg gcagggttga tcccggggaa tcggctgagg aagcggcagt gcgggagata 488461 ttggaagaaa cgggatacaa tgcagcgctt tctgcgaaaa taggtgttta ccaaaggcca 488521 aagtttcaag atgaacagca tctgtttttc ggaagcatta caggcggaca agcaatggct 488581 gacggcacag agacagcggg attaaagtgg gtttccccgg ggcgtttgcc gctttttatg 488641 gtgccgaatc gaaaaaggca gatcaatgat ttcaagaacg gcgctcaaga tgtaaatgtc 488701 accgtcaagg atagcgggtt gctcgcggcg atcgacctgt tgaaaagaag actgggcaag 488761 tgattcaggt ctccgggttt taaagccttt ctcctgtggt attgaaaaaa ggaaaaagga 488821 ggatacgtta tggcacacaa aactgcagga caagcaatga cagagctgct tgagcaatgg 488881 ggagttgatc atgtatacgg catccccgga gacagtataa atgagtttat cgaagaatta 488941 agacacgaaa gaaatcaact gaagttcatt caaacccgcc acgaagaggt agcggcactg 489001 gcagccgcgg ctgaagcaaa actcaccggc aagatcggag tctgtctgtc aatcgcaggg 489061 ccgggagcgg tgcacttatt aaatggttta tatgatgcta aagccgacgg cgcccctgtg 489121 ctggcgattg caggacaggt ttcttctggc gaagtcggac gggactattt ccaggagatt 489181 aagctggagc aaatgtttga ggacgtggcc gtgttcaaca gagaggtaca tagcgcggaa 489241 tcacttccgg atctcttaaa tcaggcgatc aggaccgcct acagcaaaaa aggcgttgcg 489301 gtattgagcg tgtcagatga tttgtttgcg gagaaaatca aacgggagcc cgtgtatact 489361 tcaccggtgt atattgaagg gaacctagaa ccgaaaaaag aacagctcgt cacctgcgcc 489421 caatatatta ataacgctaa gaaaccgatt atcctggcag ggcagggaat gaaaaaggcg 489481 aaacgggagc tcttagaatt tgcggacaaa gccgccgctc cgatcgttgt tacactcccg 489541 gcaaagggtg ttgttcccga taagcaccca cattttctcg gcaacctcgg tcagatcgga 489601 acaaagccgg cttacgaggc aatggaggaa tgtgatttat taatcatgct cggaacgtca 489661 ttcccgtacc gtgattattt gcctgatgac acgccggcga tacagctcga ttcagacccg 489721 gcaaaaatcg gaaaacggta tccggtgaca gcgggccttg tctgtgattc ggctctcggt 489781 ttgcgcgaat tgacagagta tattgaacgc aaggaagaca gaagattcct gaatgcctgc 489841 acagaacata tgcagcattg gtggaacgaa attgaaaaag atgagacaga ggcaacaaca 489901 ccgcttaaac ctcagcaggt cgtggcccgt cttcaggaag cggcagccga tgatgcggtg 489961 ctctctgtag atgtcggcac tgtgacagtc tggatggcgc gtcatttcaa aatgaacgcg 490021 aatcaggatt tcatcgtttc cagctggctt gcgacaatgg gctgcggcct gccgggagcg 490081 attgcagcga gcttgtccga accggaacgc caggcgatcg ccgtctgcgg tgacggggga 490141 ttttccatgg tcatgcagga ccttccgacc gccgttaaat ataagctccc gatcacagtc 490201 gttattttaa acaacgaaaa tctcggcatg attgagtacg agcagcaggt caaaggcaat 490261 atcgactatg tcacaaaact tcaaaatgtc gactatgccg catttgcaga aagctgcgga 490321 gcaaagggca tcaaagtgac caaagcggaa gagcttgcgc cggcttttca tgaggcgctg 490381 cactctgacc aaccggtcgt agtggatgtc atgattggaa acgaaccgcc gcttcctggc 490441 aaaatcacct acgggcaggc gaaaggcttt agcaagtaca tgctgaaaaa cttcttcgaa 490501 aaccaaaaat ttgaaatgcc gtcactgaag aaaagtttga aacggttatt ttaaaaaaac 490561 aggggcccta agagcccttg tttttttttt tttttttgga aacaaatgta ttttcagcat 490621 gtttgaattc ataaaatgat cggtatatgt attaggaact gatttcgcca tactcgaaac 490681 agacaaaagg acaaatgcat cttgtttcaa aggaagatgc atttgtcctt gcatgcttat 490741 tcttatcaaa tcttacagaa ctcttctcat aataggttat ttttcttttt tcttcagccc 490801 gaagaagaaa ggaaaagcag aaccgaccaa gaaggtgccg aataaaaaca tgccgccgat 490861 aaacacgtgg aaatttgtgt gtccggccgt aaacgccgtg attagggaaa tgatactgag 490921 cacgatcatg gcaatgccgg gcgcgactct catttttccc ttggatttat gggcagcaac 490981 agaacataaa atgccgataa caataggaac aatccacaaa taaaacagaa taaatactga 491041 catcatcaaa actccgattt ttcttctatc ataacaaatt tctgtcaaaa agggtatcaa 491101 tgagcttttg cggaaaaata aaaaccggct ttagaagccg gtttttttat cgaaacgtat 491161 ctacaattaa aaacacattc aaagcaacga tcaatacagc aatcagccaa gacaccactg 491221 tgatccattt ggcgttgatc agagatccca tgatccgttt attgcttgta aacataataa 491281 gcggaatgag ggcaaaggcg atcccgaagg acagcacgac ctggctcagt acgagagcgg 491341 tcgtcggatt aacacctgac gcgatgatca agatcggcgg aatgatcgtg ataaaacgcc 491401 gtacatacag cggaatgcgg tagttgataa atccttgcat aatcacgtcg cctgaaagtg 491461 tgccgacaga cgaactggat agaccggcaa cgagcagccc gatcccgaac aaagccgcag 491521 acatagggct gacaagatgt ccgaattgct gaaatgcgac gtcgagatcc tcaacaaaca 491581 ggccgttttt gaagaataat gcggcagcca caatcagcat acttgcatta atagcccctg 491641 caatcagcat cgctattaaa atatcaataa attcaaacct aaagattttt ttccgttctg 491701 catcagtttt gccaaccacc cgccgctgtg taagggcaga gtgtaaataa atggcgtgcg 491761 gcataacagt tgcgccaaga atacccgctg caagaagcac actgtcggtg ccatgaaacg 491821 ccgggacaaa aaggcccttc atcactgaca cggcatcagg ctttgcgaaa aaggtctgca 491881 acgcaaaggc gatcacgacc acaaacagca taccggcaat acctgcttca agtgagcgat 491941 aaccacggcg ctgaagctcc aatatcgcga aagaaccgat cgccgcaata atagacgctt 492001 caagcatcgg aatgccgaac agcaaataca gtcccagagc cgctccgata aattccgcca 492061 gatcagttgc gataatgacc aactcgccct gaatccataa tccgatcgag acaggcttcg 492121 ggaattcttc acgggcaacc tcaggcagat ttttgcctgt cgcaataccg agtttggcgg 492181 atagggattg aattaaaagc gccatgatat tggaaaataa gatcacccat aagagcatat 492241 atccgtattt agaacccgcc gaaatattcg ttgcgaagtt gccgggatca atataggcaa 492301 tggctgctat aaatgcaggg ccgagaaaag ggagcagccc tctgaatcct ctgattttcc 492361 cgtcaagcgc atcttggacg gctttggaac ggggagattg tgctgtgatg tccttgttca 492421 tcatgtctca cctgaattct gtttgttttt gccgtacaac aaagagtttc cttaaggcaa 492481 attattttat ctacatcata tgaccatccc ggtttcttgt caaccgaaaa tgttcaaaat 492541 acacttctga atttttccct gttatgtaac atgatatgta gggattcgtg ataaggtccc 492601 atataaaaag acatcgtttc atttcgaaac gatgcctcct gtatctaatg agtctaggct 492661 tccttccgca gcccgcggaa tataaggccc agcaagaaca cgaagatggc tgccccgatg 492721 atggccggga aaatagcaaa gccggcgagg ctcggtcccc atgtgccaag aagtccgtgc 492781 ccaatccaag cgccgatcag cccggcaatc atagagccga aaattcctcc cggcagccgg 492841 tttcctacaa tggcgctccc aattaatccg ataacaattg caacaactaa tgaaaccaaa 492901 aagctaagca tcatgatcac ctctcataaa tgatttacca atcaataacc gctcctgatc 492961 atttcgaaac acttgaaagc atattccttt atgatcctgt tttaatcttt ctctgcacac 493021 tgccgtcagc taaatgaaca atgacctcag tgcctttatg cgccgcgatt tcctttgccc 493081 gttcaatcgc ttctttcttt gtatccttga tttcagacac acgtttggcg ccctcggctt 493141 tgactgccca gcctttttta tgcttaataa catgctctgc tttattcatg agctcggggc 493201 cgctgccgct gcttggatca gcatcgcgtt ctgtctcatc atcatgcgtc aggaaatcat 493261 caatttcatc tgtagaggcg ttttccgccc attccttcgc tttgcttgtc gcaattggaa 493321 tcgcgcgccc ttcctcatag ccttcatcaa tcatcgcatt cgcaatgtct atcgcctttt 493381 ttctcaccgg cttctcaaga ttttttaatg aagcaggata atccttcatc gaccaaggca 493441 tgtctatcac tccttttcct tttataaaaa tggtacccgc aggtgaaaaa taaaaacgca 493501 tccgaaaaaa tgaaggtata ctatatagta gaaaaaacgg aagggaagtg cgggttgggt 493561 gccaacagaa cgaaaagaag acttacatca gcaattaaaa gagatagaga aatgggaaaa 493621 agatcagcaa aaagtctggt tttgggaaaa gctcagccgt ctcccgtttc aactcctgga 493681 caagctgaca ccagaattca tccagaaaaa gatcggcaag ctcttggatg aggtcggcag 493741 ctttgttcaa acaggcggac agtacctgac atctgaaaaa cagattatca ggatgtttca 493801 aaagaaactg ccggaggaga tctttgaatc gctggaggac atccggaaag cgcctcttcc 493861 tgtcatggat gaaattgcgg aaggaatggg caaaaacaga accaacgcag caaccgttca 493921 aggcgcgaca accggtgtgg gcggcgtgtt tacgctggcg gcagacattc cggcagtgct 493981 tggcttatca ctaaaaacat tacaggatat cgcagtcgca tacggctatg acccaaagga 494041 gaaaaaagaa cgagtcttca ttgtgaaatg cctgcagctt acgtcggctg atgttgtcgg 494101 caaaagatcg attttgcagg aattaaaaca ctacgatcaa gaccgtacat ataagaatgt 494161 cgcttctcaa atccaaggct ggcgagaagt cgttttgggc tatcgagaca cgtttggctg 494221 gaaaaaactt ttccagatag tgccggttgc cggaatggtt tttggcgccg ctgccaatcg 494281 ctcaacatta aacgacatta ccgagacagg catgatgctg tacaaaaaga ggcgcattct 494341 tgaacgactg aaagaaacag aacgagagat ggaatagcag aaagcagacg gacaccgcga 494401 tccgcctgct ttttttagtg gaaacatacc caatgtgttt tgtttgttta aaagaattgt 494461 gagcgggaat acaacaacca acaccaatta aaggaggaat tcaaaatggc agacaataac 494521 aaaatgagca gagaagaagc aggtagaaaa ggcggagaaa caacaagcaa gaaccatgac 494581 aaagaattct atcaagagat tggtcaaaaa ggcggagaag ccactagcaa aaaccatgac 494641 aaagaattct atcaggaaat cggcgaaaaa ggcggagaag ccactagcaa gaaccatgac 494701 aaagagttct atcaagaaat cggtgaaaaa ggcggagaag ccactagcga aaatcatgac 494761 aaagaattct atcaagaaat cggccgaaaa ggcggagagg caacaagcaa aaatcatgat 494821 aaagaattct accaagaaat tggctcaaaa ggcggaaacg cccgcaacaa cgactaatca 494881 aaagcataaa ggcagacaac ctgtaaataa aaaagcgatc cggcacatca gctggatcgc 494941 ttttttttgg aatcttctca atttatgccg ctattgagat acaataagtg aaaaaggggt 495001 tttcgctaat gtccaagatg caaaacttgc tcgccatcgc aaatgaagtc aaagaaaagc 495061 acgccaattt ttcaatctca gaggtcaacg accactgcgt gcgccttgcg gtgtttacgg 495121 gagaatatga ctggcaccat caccctgact cagacgaatt gtttattgtt cttgaagggg 495181 agctgctgat cgattttaag gacaaagaaa ccgcggtgct caaagcaaat gacagcctgc 495241 tgatccctaa aggcacggtt caccgcacac gctcttacgt cagaacggta aatctctgtg 495301 tggagcataa acaagccgaa accgtcatca tagaggagca gccatgctaa tcaaaaagat 495361 gatatgtgaa gtagatgctg caaacgctga agcatttgca aaagcgcagt cacagtggga 495421 agcgttatcg catataagcg gctttatcaa acaggccggc ggctggcgaa aaacgataga 495481 cgagccgctc accgcagaaa tcatcagtgt atgggaaaac agagaagcct atgatcattt 495541 tatggagaac gaacatgaca gcatatacga ggaaaacgat cagaaggctg taattctttc 495601 gatagaggtg acggtgtacg aagaggataa accgttcgtt cacgatctgt tacataaccc 495661 cgatatccgg tacgaaccaa actggacggt tctgaaggca taatcaaagc ccaaaacatc 495721 atgttttggg cttgtctctt tactcgcgtc ccggaagtgt attatgaaca aaaggcggtg 495781 ctggttttaa ctccggtttt tctccaaacg tttttgcttc tttcacatat tcaaaggctt 495841 ctccgtccgg cgctttttca ttcagccagt tttgctcggc gcttacttcg ccttcagaga 495901 aattgataag ctgatgtgag aactcttgtt tttcgagcgc tttcgggaat gtacccggca 495961 caaccggacc ttcctgtgct tctaattctt taatggcggc gagccattgg ttctggtgca 496021 tcgtgtcacg cgccagcagg aagctgagca tatctttgac gcctttgtca tccgtcattt 496081 caaacaggcg tgcgacctgc agacggccct gagattccgc attcaggttg gcgcggaagt 496141 ctgccagcag gtttccgctt gctacgatat aaccgccgct ccaaggtacg cctgtactgc 496201 tttccggcat ggcgccaagt cctgatacaa tcgcatggtg agggttcatg ccgcctagga 496261 tggagccgat gaccggatct tcagcagctt tttcctgctg atcaagaggg gcatcctcaa 496321 gaagtctggc aatcatcgtt gcgatcattt caacatgccc gagctcctca gttgccgtat 496381 ccatcagcaa gtccttgtat ttttcatttc ctcttgtgtt ccagccttga aataagtact 496441 gcatggcaac tgaaatttct ccgaattgcc cgcctaaaat ttcttgcatt tttttagcga 496501 ataatggatc tggacgatct ggtttagcag gatgctgcag catttttgtg tgcttaaaca 496561 tgtacccatc tcctttttcg tttatctctt tttatatttc cgatcgatag aaagataaac 496621 gaaaaacagc gtatcgagat gggaactatg aatcttttcg cagctccaac agttcccgga 496681 tcagctcccg gccaaagatg ggctcatact gccggtaaac agggtcaaga cgcttcatcc 496741 attcttgttt ctctttatct gacagctcat aaatatgtat agcagaattc tttttgattt 496801 cttccagctg ctccttgttc atttgttcgg catacgtttc attccactcc gttgtctcct 496861 tcatcgcttc agtcaaaatg cgtcttgttt ctggtgtttg cgccttccag aagtgttcat 496921 cagtcatgac agcgtagccg agataaccgt ggctgcttat tgtcaaatag tcctgaacat 496981 tataaaattt tttagaatag atgtttgaaa ttgtattttc ttcgccatcg actacattgt 497041 tttctaacag ctgaaaggta gaattgaagg attcctgatg aggtgttgcg ccaagcagct 497101 tgaactgatc ctcaatcaca tcgctttgca taatgcgcag atcctgccct tttaagtcat 497161 ccggtgtttt gaccggccct tgatttgttg tgatttgctt aaagccgttc gtccaatagg 497221 ccaatccttt caattggttt ttctttagag aatcaaacag ctgtgtgccg atgcttccgt 497281 tcagcccttt tttgacggcg ttgtaatctg taaatgcata cggcagatcc agcactcccc 497341 attcaggcga gagcatgccg agcttcgatg tggagggggc gataaattga acatcgccgt 497401 tttgcaatgc ttcaatttct tcaatgtccg agtacaggct tccattcgga aatacttcta 497461 tttttatttt tccgcctgat ttttcgttca ccagatcagc gaatttattg gcggccagcc 497521 cttttggcgt attttcagca accacgtggc tgaatttaaa cacgatttga tcctgcaggc 497581 cttcctggtc gtcatcataa acaatctttt tattgccggt atgatcatgg aatccgataa 497641 ataaagcggt tgcaattcca gcgatcatca gtgcgagaca tgcaagcaaa ctcttcatga 497701 aaagccctcc cctatgttaa ggataatggg ggctatgaca ttcgtaaaga cctgaaagga 497761 gaagctgatg aacaaaaaga agctctcaat ccgttggaaa atcacgatct tatcctatat 497821 actcgtcatt ttctcctttt tgatcggcgg cattgtgctc atcggcaaca ttcagcatac 497881 agaggagcgg gagctgaaaa agcggctgat gaatacggcc cggacggtgt cagagatgac 497941 agaagtgaaa gaagccttgg cgcgaaaaaa acaaacagaa gcggttcgcc atgcggttga 498001 agaaatcagg atgattaatg aagcagacta tattgtcgtc atggatatga atcacatccg 498061 atatacgcat cctgtcagca caagcattgg caagaaatca gaaggtgcag acgaggaggc 498121 agcttttgcg gagcacattt atttctctga agcaaagggc gagatcggca cggcggttcg 498181 cgctttttat ccggtaaagg atcaagacct gaaccaaata ggcgtggtgc ttgtcggaaa 498241 aacgctgccg gggatcgctg acatcctgct tcatttaaag cgtgatatcg ccttcatcgt 498301 tgtgctgaca ctcggctttg gccttgctgg ttcctttttg ctggcccgcc atatcaaaaa 498361 acaaatgttt cagcttgaac cccatgagat tgtccgaatg tatgaagaac ggacagcgac 498421 gtttcactcg atgaatgaag gggtgatcgc tattgacaat cgtctcgtca ttacgatctt 498481 caatgaaaaa gcgaaacaga tctttgaagt gcagggggat ctaatcggca aggtgatttg 498541 ggaggttctc aaggattcgc gcctgcccga aatcgtggag cggaacaaag cggtttataa 498601 tgaagaaatt cgtgtcagcg gtaaggtgat catgagcagc agaattccga tcgtcatgaa 498661 gaaaaaagtg atcggcgccg ttgcgatttt tcaggacaga acggaagcgg ccaagatggc 498721 agaggaattg actggtgtca gaaactttgt ggaggcgctc cgtgtccaaa accatgagca 498781 tatgaataag ctgcacacga tcgccggtct catccagctg gggaaatctg aaaaagcctt 498841 gcagcttgca ttccaggcgt caactgagca ggaaaatgtg actgaatttc tgcaccgctc 498901 gattcaaaat gacgctgcgg caggccttct attaagtaaa atcagaaggg gaagagagct 498961 cggcattgct gttcatatag atgaaaacag cagtcttcag caatttcccg agcatgttga 499021 tcagcatgat attgtcgtgc ttttggggaa tctgattgaa aatgccttcg gctcatttga 499081 aaccgttcaa tctgaagaca aacgaattga cattagtatc gaacaaacag atgatatcct 499141 tgctatttta atagaagata acggctgcgg aattgaaccg acacatatgc ctcgccttta 499201 tgacaaaggt tttacggtca ataaaactgg cggcacaggc tatggcctgt atctagtgaa 499261 acaaatcata gacaaaggat cgggcacgat agaagttgat tcacatgcgg ggcaggggac 499321 atctttttct atcgtttttc caatgaaggg ggaggaagca cagcatggct cgtaaagaat 499381 ggaaggttct gctcattgaa gacgatccga tggttcaaga ggtcaataag gatttcatta 499441 caactgttaa aggcgttact gtctgtgcaa cggcaggaaa cggagaggaa ggcatgaagc 499501 tgattaaaga agaacagcca gatctcgtca ttctcgatgt gtacatgccg aaaaaagacg 499561 gcatcaagac cttgcaggag atcagaaagc aaaagcttga agtggatgtc attgtcgtct 499621 ccgctgcaaa agacaaggaa acgatctcac tcatgctgca aaacggggcg gttgactata 499681 tcttaaagcc gtttaagctt gagcgaatga gacaggcact cgaaaagtac aagcaatata 499741 aacaaaaaat cgaagcgaat gatacgctgt cccaggaaca gctcgatgcg atcctgaata 499801 ttccgcagca ggccgtacag gatctgccga aagggttgaa tcacttcacg atgaatgaag 499861 tcactgcttt tttgaaacag caaaccgcat ccctttctgc tgaagaggtt gccaaggcgc 499921 tcggcatcgc cagagtgaca gccagacgat atcttgatta cttagaaaaa accgggatca 499981 tcaaattgga cgttcaatac ggcggagtcg gccggccggt caaccgctac gtgttaaaag 500041 gataaacctg agaccaaaaa gaccaaaatg tccgttatga tcataaactt ccccagactg 500101 tatgaaaacg ctatcattct agtaagaaag acacaaaagg cgaataggac agggggatga 500161 aggatatgaa actgtttaaa aatttaacag ttcaggtcat aaccgcggtc atcatcgggg 500221 tcattgtcgg gctggtctgg ccggatgtcg gcaaagaaat gaaaccgctt ggtgatacat 500281 ttatcaacgc tgttaaaatg gtgatcgcac caatcatttt cttcacaatc gttctcggga 500341 ttgcaaaaat gggcgatatg aagaaggttg gaaaagtagg gggaaaagcg tttatctatt 500401 tcgaggttgt caccaccctc gcactcatta tcggtttatt tgtcgtcaat attatgaagc 500461 cgggtgcggg tcttgattac agcaagcttg aaaaaggaga tgtatcacaa tacacgcaaa 500521 atggcggtca gggaatcgac tggattgaat ttattacaca cattgttccg tccaacatgg 500581 ttgatgcctt cgcaaaaggg gacattttgc aggtcttatt cttttctatt cttttcggag 500641 tgggtcttgc ggcattaggc gaaaaaggaa aaagcgtcat tgatttcttc gacaaggttt 500701 ctcacgtttt tttcaaaatt atcggctaca ttatgcgtgc cgcgccaatc ggggcattcg 500761 gggcgatggc gtatacaatc ggacacttcg ggctcgattc catcaaaccg ctggcaagct 500821 taatgatgtc tgtttatatt acgatgttcc tgttcgtatt tgttgcttta aatatcatct 500881 gcaagcttta cggattcagc ctgtggaatt accttcgctt cattaaggat gagcttttga 500941 tcgtgcttgg cacaagctct tccgaatcgg tgcttccgcg tatgatggat aaaatggagc 501001 gctacggctg ttccaaatcc gttgtcgggc ttgttattcc gacgggctat tcgtttaacc 501061 tcgacggcac atccatctat ttatcaatgg cgactgtctt tttggcacag gtgtttggag 501121 tagacctcag catcggccag caaattacga ttatcctcgt tctgatgctg acatcgaagg 501181 gagcggcagg tgtgacggga agcggattta tcgtccttgc ctcaacgctg tcagcgctgc 501241 aggtcattcc gctggagggg cttgcactcc tgctcggggt cgaccgtttc atgagtgaag 501301 gaagagccat tgtgaacctg atcggaaacg gaatcgccac gatcattgtt gccaaaagcg 501361 aaaatgaatt tgatgaagca aaaagcatag aggctgttga aggcatgaaa aaaatgaaaa 501421 cagcagtctg aaaaaagaac ggcccatcca tgggccgttt ttttaattgt ttaagaatta 501481 ttaaggtaag gacagagacc tcagcatttt tttgttatat aatttacaaa tggatactat 501541 attgaatgaa ggacgtttgt cctaacagga gtgtataaat ggccgcttta gttaaatttt 501601 ttcagcaccc gggagtaagg cgtttctcca tctttgtcgt gttaactggt gtgttatatc 501661 tatttaagag catgatcaac ttaatattgc ttaccttcat tttcacattt ctaatggatc 501721 gtttggagct tgtcgtgcgg cagtttgtaa gccagttctt ccgcgtgagc cagcgggttg 501781 tcattacgtt tctttacatg ttgctggctg tgctgcttac agtcgggggc tttgtgtttt 501841 atccggtcgt cgcggcgcag atccagcagc tggtaaagca gattaaacat attgcgtatc 501901 atcctgacag catccctttc tttgatgaga tcaccagtgt cttcggagat attaacatca 501961 gttcatatgt caaagagggc ttcaatgtag tgtatacgta tctggccgat atcagcacat 502021 tcggcttgca ggtcgtgatg gcgctcattc ttagcatgtt tttcttattt gagaaaaaac 502081 ggctttctga attcatggcg aaatttaaaa cgagcaaact tagggtcttt tatgaggaga 502141 ttgctttttt cggaagcaaa tttgcaagaa cgttcggcaa ggtgctcgag gctcaattta 502201 tcattgcgct cgtcaactgt attctgacgt ttatcgcgct ttggattatg cattttccgc 502261 agctgtttgg gctttcgatt atggtgttct tccttggatt gatccctgta gcaggcgtcg 502321 tcatttccct gattccgctc agcattatcg cctacagcac tggcggtgga atgtatgtgc 502381 tctacattgt ccttgtcata ttcgccattc atgcgatcga aacctatttc ttaaatccga 502441 agctgatgtc ggcgaaaaca gagctgccaa tctttttcac cttcacagta ctcattttct 502501 ctgaacactt cttcggcatt tggggtttaa ttatcgggat tccgatcttt gtgtttctcc 502561 ttgatattct ggatgtcacc aacaaggaag ataggtctaa aggaccccga gagaatagcg 502621 ataaaaagta gtttaaaatc gaataatgag tgtgcctcga tctgccggcc tgcctgttca 502681 gggcatggaa ttaagactcg gaatcggagc ttggcattgc cttgcacagt ggtgaacaca 502741 acaggtgaca atgcttgtca tcagtacgga aactgaaaag aacaaacagt cggagcaaac 502801 gctcatcatc ggtttaacca aacatttgga agcaacaaat gctataatac aaacagtgcc 502861 taatgttggg cactgtttat tttttgtcga aaaaggagga aggctttatg gctgagccga 502921 ttttacatat tgaaggcctc gataaaaaaa ttgggtctaa acagatttta aaacagatca 502981 gcatggacgt catggagggt gaaatcatcg gccttctcgg tccgaatggt tccggaaaaa 503041 caacactcat ccgtatcatc gtcgggctgt tgaaacaaaa cagcggaagc gtgacaatca 503101 gcggattcca gcatgataca gagtttgaaa aagcgatgga agcggttgga gcgattgttg 503161 agaaccctga gttctatccg tacctgacag gctgggaaaa cctcaagcac tttgcgaata 503221 tgcacaaaaa aatagcggat gaacggcttg atgaagtggt ggaacgtgtc gggctgacgt 503281 cagcgattca tgataaggtg aaaacctatt cccttgggat gcgccagcgt ctgggaatcg 503341 cccaggcaat tcttcaccgg ccgaagcttc tcattctaga tgaaccgaca aacggcctcg 503401 atcctgcggg gatgaaggat tttcgggatc atattaagga actcgcagaa atggaaggaa 503461 cagctgtcct gttcgccact catttattgc gcgaggttga agacttgtgc gaccgtgtca 503521 tcatcattca aaaaggtgag atcaaagcgg aagtcagctt acaaggaacc gatcaaacca 503581 cagaaaaagc gattatagaa gtgcagccgc aagaaaaagc gctcaattgg ctgacaggca 503641 atcaatatca agctgagagc caagacggga cgattgtagt tgaggtggca aaagaaaaca 503701 taccggagct gaaccgatca cttgtcggac aagatctgaa tgtattttcc attacgcctt 503761 acacgcagtc actggaagac gaatttataa aagcgacaac agctcatcaa gaggagggag 503821 aagagcttgt ctaaattaat ttggaatgaa catatgaaac tttttaatcg gaaggtcact 503881 ttggtttctc ttatcctgat ggctgtcttt caattcttca tggcattgat cattaaacgg 503941 attgtcatca gtgccggaac agatgaaaac ttcatcggct atttatcgta tacaccgagc 504001 ctgaacattt tgctgcaggc tttaacgatc gtaattgcag caacaattgt ttcgatggaa 504061 tttgataaaa agacgatcaa atttttgctc attcgtccgg ttaaacgcca aaaggtcttt 504121 tggtcaaaat taatcacagt cgtgatggtc agcttctatt tgtatttggc atactacatt 504181 ctggcattat tattcggtct cttgtttttt ggcacatcgg tgactgcgga atcaaagaca 504241 ttgctggtca acaccttggc gctgatcggg tcaaactggc ttgaagctgt aatgatggga 504301 ttattcgggc tgctttgttc ttcgctgttc cgcaatagcg cggtagcagt tgttgtttct 504361 tttgtcgttt tatacggagc gagtacactt gttcagctca tgaagttgtt tgaaaacaag 504421 tggggcagct ttttgctttt tgcgaacact gactttacgc aatacagaag cggagagaca 504481 gcgttgtttt caggcatgac gccattgttt tcaattggaa ttctcatcat acatgccata 504541 ttcttcatcg ttgttggctg gtggtgcttc tgtaaacggg atgttcgggt ctaaaggcaa 504601 ggaatgacat ttttgtgaaa aagctcacgt aaatcaatat catttgatat tttggtttat 504661 actaaaggta ctgacggagg tgtctcgatt gaggaacttt attaccgctt taccgatcgt 504721 attgctgctt ggattctcat ttgtgtcatt catgtttcag tttgaacatc ttgtttattt 504781 caggctcgcg cttgggttgt tttctctcgt gggactgtac atgatatata aaatgaagac 504841 gggcatccgc tattttatca tctatctgta tgccagctgg attgtgttgg ccgcagtgac 504901 cgcttttgaa gagccgattt tctcaagctt tttctttggc ggcctggtga tgacgatggg 504961 ttacctgaca tatatgctga tttatctcgg catgaaacaa gaccgggatg caaatcctgt 505021 gtaatcgcgc tgttcccttg gggaacggcg tgtttttcta tactgggcaa aaggttaaca 505081 gttgcggaaa aatggcagga aatctataat acatattaaa tttatcggaa ttaaaactgg 505141 ggggctgccg gatgtcatta tttatacaaa acgatcaaca gcggcaatgg atggagaaaa 505201 tcggacggat tgcggatgaa tttcagcaaa cagctgctga agatgacgaa cagggacgtt 505261 ttcctgcaga gaaaatacaa aaactgcgtg atgctgggta tacagcatta acattgccgg 505321 catctcatgg cggagggggc atttctgttt acgatatgct cttgtttcaa gaacggcttg 505381 cacggggaga tgctccgacg gctcttagca tcggctggca tttgagcgtg atcggggagc 505441 ttggagaagg caacagctgg gatgaagacg tatttgcatt tgttgccaag gaagtccaaa 505501 acggagccgt cattaacagg gcggcgactg aagcgaaaac cggaagcccg acaagaggag 505561 ggcgtcccgg tacacacgcc gtcaaaaagg atggcaaatg ggcagtgaac gggagaaaaa 505621 cctttacgac gatgtcacaa gctctggatt attttttagt aaccgcatgg attgaggaca 505681 aacaaacaac aggcgtgttt ctcattcata aagatgatcc cggcttgtcg attgaagaaa 505741 cgtgggatat gatggcgatg cgggcgactg ggagccatga ccttgtactg aacgaagtaa 505801 tgcttgatga gaataagctg gtggaactgc ttcaagggcc tcgtggagct aagccgaatg 505861 gctggctgct tcacattcct gcgatttatc ttggtgtggc tcaagctgct cgtgactatg 505921 cagtgcaatt tgcatctgag tattctccaa acagcttgaa tggaccgatc aagaatgtcc 505981 cggccgtaca gcaaagaaca ggcgaaatgg agcttgaact gctcaatgcc agacactttc 506041 ttttccatat cgctcaattg tatgacgatc cggtgcggcg tccacacttg accagcgagc 506101 tcggtgcggc gaaacatatc gtcacaaacg ctgcgctgtc tgttgttgat aaagcgatga 506161 gaattgtcgg ggccaaaagc ctggaacgaa ccaacccgct tcagcgctat taccgtgatg 506221 tgcgcgccgg tcttcacaac ccgccgatgg atgacgccgt gatacacaag ctggcagctg 506281 aagcgtttga gtcataaaaa aaagagcctt accggctctt tttatgtatt gttttgctct 506341 tgcagatttt tttgatgctt gcggtcgatc ctgtcataaa taacgttcat cagctttgga 506401 ttgcccataa tcgcctcttt gttttcctgg atcagctgtt ggtaagtttt cactttacgc 506461 ttcggcatgc tccggcgccc tcctgacatg tttgtattca ctttctaact ccgtcagcga 506521 caattcatac agatgacgct ttgacttttt gtatatacca ttctgtatta acagatgaat 506581 gagctgtttt tttctgattt ctgcagactg aggtgtcatt gtgtcaccaa cctccaatca 506641 aacgatattg ataatcatta tcaattaact tcagtataca atgtccgcaa tagcctgtaa 506701 agatgaaaag agtcctattc ttggccaatt tacaaacatt caacaaatcg acaaaaagtt 506761 tcccgggcaa taatttgctg tcgaaatatt ccgcttcatt gaacgcaccc tgctattttt 506821 catgttttga accatactat gtaatagaat ggaggctggt attcaatgga gcggacagaa 506881 aatctgaaaa agggagaaaa aggggcgctc ctcaatattt ttgcatatgt catccttgct 506941 gttgtaaagc tagttatcgg gattctatat cattctgaag cgctgagagc agacgggtta 507001 aataatggaa cagatattgt tgcgtcagta gcagtgctga taggattgcg gatttctcaa 507061 agaccggctg acagcgatca tccatacggc cattatcggg ctgaaacaat ttcgtctctt 507121 gttgcgtctt ttattatgat ggcagtcggc attgaagtgt taatcggcgg aggaaaagcg 507181 attgcgggcg gcacaacgga aacgccaaat cttatcgcgg catggacggc gttaggcagt 507241 gctgtgttta tgtatggcat ctatttatat aacaaaaggc tggcagcgtc cattaaaagc 507301 tctgccctga tggcagcggc aaaggacagc aggtcagacg cttttgtaag tgccggcgcg 507361 tttatcggtg ttttttcgtc ccagctgaag ctgccgtggg ttgatccggt aacggctttt 507421 atcatcggca tcatcatttg caaaactgcg tgggatatct ttaaagacgc ttcacattcc 507481 ttaacagacg gcttccattt aaaagatctt gagccttaca aacagaccgt cggcaggatc 507541 gaaaatgtgc atcgcctaaa ggatgtgaaa gcgaggtatt taggcagtac agttcatatc 507601 gagatggtga ttacggttga tccgaagctt acagtagaag aaggccatgg agtggcggat 507661 gaagtagaag acaaaataaa acatgaacac gatgtcactc atgttcatgt tcatgtagag 507721 cctgacgaca taaaataagg ctgtttaacg aattagctta tatgttcaga taaaaattca 507781 gtcacttctt caggcgtttt ggcattggcg ctgtgaaggt gagctgtttt ttcaccgttc 507841 ttgaaaataa gcaggctggg aatgcccatt acttggtatt tttcagccag gtcaggaagc 507901 tcgtccttat tcagctcata ccagtcgttt tggttgtatt cttccaaaat atcgccgatg 507961 aacatattca tgcgtgtgca gtctgggcac caatcagcat aaaactttac aatgatttct 508021 ttatcagatt gaatcagttc attaaattgt tcgtttgttg tgattttttt catatgtcac 508081 atctcctttt caatgccatt ttaatataaa ataaaaagga attacataca aatgcattca 508141 acatcagcat gcccaaaaat aattagatca ttttccggtg aaaatgataa gatagtaaag 508201 atgaattgta gtggggggag tatccattga aaacaagtct aggattagtg tacggaggaa 508261 agtcggcaga acataatgtt tccctgcaga cagctctggc tgtaatcaaa gcgctaaata 508321 ctgagaagtt tgatatacat ccgatttata taacagaaaa aggcgaatgg gttagaggcg 508381 cccgtttaac tgaacctgtt tcaaacgtga aaatgcttca atttgagcaa ggaggcagtg 508441 ctttttctcc agctgccctg aaccaggaga tgtttccgca ggaagcgtca cagcaaaatg 508501 aagccatcga cgtcgtattc ccgctcctcc acggaccgaa cggagaagac ggtacgatcc 508561 agggaatgct cgagctgttg aacattcctt atgtcggcaa cggagtgctt gcttcctcag 508621 ctggcatgga taaagttgtc atgaaacatt tatttgcgca ggttggcctt gctcaggcta 508681 aatacgcagc tttccttaag aaagactgga ctcgttctcc gaaagaaagc tgtgaggagg 508741 ttgaacagga attaggctac ccttgcttcg taaaaccggc gaacctcggc tcaagtgtcg 508801 gaatcagcaa atgccgaaac cgtgaagaac tgcaaaaagc gtttgagctt gctttccaat 508861 atgaccgcaa agtcgtcgtt gaagaaggaa ttaacggccg cgagatcgaa atcggcgttc 508921 ttggaaatga tgatcctaaa tgctctgttg tgggagaaat cgcaccgaag acagatttct 508981 acgattacaa agcgaaatat gaggatggag atactgatct gatgattccg gcgattgtga 509041 ctgatgagga atacgcaaca atcagtgata tggcgatcaa agcgtttaaa gcgatcgacg 509101 gttcaggact cgtcagagcg gactttttcc tgacagctga cggcgaagtt ctgatcaatg 509161 aagtcaacac aatgcctggc tttacacctt tcagcatgtt cccgttgctc tggaaagaag 509221 ccggagtgga atatgctgac ctgattgaac agcttgtgga gcttgcaaaa gaacgccacg 509281 ctgaaaaaca attgattaag catacattct aatgaagaag gacactgccg gtaaaagggc 509341 agtgtttttt cccgtatata caaaagaaag agagggacct tacttgatta agcgaacagt 509401 aaaaaacatt gccgaaatgg ttaaaggcac actagcaaat ccgcaatatg aacaaacagt 509461 cattcatgga gtggcaaccg atacaagaaa actggaacaa catcagctct ttattccgct 509521 gaaaggggaa cgttttgacg gccactcttt tgtggagcag gcctttgaag ctggtgtagc 509581 ggctgttctt tgggatcggt cagtaccaaa tccgcccgag aatcacgccg tcattttagt 509641 ggacgatacc cttactgcac ttcagcagct tgcaaaagct tatttgcagg agcttggcac 509701 gcgtgtcatc ggagtaaccg gaagcaatgg caaaacgaca acaaaagata tgattcacgc 509761 cgtattgggg acccagtacc gtgtccacaa aactggagga aacttcaata atcatatcgg 509821 tttgccgctg acggttttag cgatgcctga aaatacggag atcgccgtat tggagatggg 509881 aatgagcgcc aaaggagaaa ttgacctctt gagccgactg gcaaacccgg atgcggcagt 509941 gattacgaat atcggcgaat cgcatatgca agacctcggc tctagagagg gcatcgcgga 510001 ggcgaagctt gaaatcataa acgggcttaa agaagacgga gtgctgattt atatcgggga 510061 cgaaccgctt cttcaaaatg catacagctg ccagacgaaa acgtacggta cgggaacgca 510121 taatgattat cagcttcagg atgtcagcca gagtgaggaa ggaacccatt ttacaatcaa 510181 agggatagaa aacacgtttt ttattccaat actcggcaag cacaatgtga tgaacgccat 510241 ggctgcaatt gctgcagggg cttattttgg catcgcgcct gaggatgcgg caaaaggact 510301 gagcggccta aaggtaaccg ggatgaggct tgaactcatc aaaacagaca gcggcctttc 510361 gataatcaat gacgcttata atgcgagccc gacttccatg aaagctgcaa ttcaattgac 510421 agaaagcctt gaaggctacg gcaaaaaaat gctcgtgctc ggtgatatgc ttgaactcgg 510481 cgatcttgaa gaaacgttcc ataaagagtg cggcgctgtg atcagccctg ataaaattga 510541 ccgcgtcttt acgtacggaa aactgggagc ttttatcgcg gaaggcgccc tgaaacactt 510601 tgagaaagac cgcgtcagcc attacactga gaaaaaagat ctccttcaag ctgtgaagga 510661 aaacgcatca aaaggcgatt tgattttatt caaagcgtcc agaggtatga agcttgaaga 510721 aatcgttaaa gatttaatag agagcccgct ttcataagaa aatattttgc gaaaaaacgc 510781 atattgcatc ataaaataac ctgatatgca aacactaatg tatgccggcc gaaaattatg 510841 tatatctggc cggctgcggc tatgatacaa tatatatagg ttatttcgcg atacgaacat 510901 attcgtccgg acttttcatc gtgacccgaa gttctccgct ggattcttgg gagcggatgg 510961 agcagcagcc ggcatattcg agatgccgat ctgcttctca tcttattgaa aaacaaatag 511021 tgtaatggta agataaaact taaagtaatt cgggctttgt atacggatgg atcctgtcct 511081 tcttgtctaa agggcagttt tataagtggt aaatcacgac attactgaaa cagcaattag 511141 aaggagtttg aataatttga ctataacgtt tcaagatttt aatttaagtt ctgatctcat 511201 gaaagcaatt aatcgtatgg gatttgaaga agcaacaccg attcaggcac aaacgatacc 511261 gctcggactt tcaaataaag acgtcattgg acaagcgcaa acaggtacag gtaaaacagc 511321 tgcgtttggt ataccccttg ttgaaaaaat taaccccgag tctcctaata ttcaagcaat 511381 cgtaatcgcg ccaacccgtg aattagccat tcaagtatct gaagaattgt ataaaatcgg 511441 acaagataaa cgtgcgaagg ttcttcctat ttacggcgga caggatattg gacggcaaat 511501 ccgggcgtta aagaagaatc cgaatattat tgtcggaaca cctggacgtc ttcttgacca 511561 catcaaccgc cgcaccattc gtttaaacaa tgtaaatacc gttgtaatgg atgaagcgga 511621 tgaaatgctg aacatgggat tcattgacga tattgaatct atcctttcaa acgtgccaag 511681 cgagcatcag acacttctgt tctctgccac aatgcctgcg ccgatcaaac gcattgcaga 511741 gcgcttcatg actgagccgg aacacgtaaa agtaaaagcg aaagaaatga cggtttctaa 511801 cattcagcag ttctatttgg aagtgcaaga acgtaaaaaa ttcgatacac tgactcgcct 511861 tcttgatatt cagtctcctg agcttgcgat cgtattcgga cgtacaaaac gccgtgtcga 511921 tgagctggct gaagctctga accttcgcgg atatgcagct gaaggtattc acggtgactt 511981 aacgcaggcg aaacgtatgg ttgcgcttcg taaatttaaa gaaggcgcaa tcgaagttct 512041 agtcgcaact gatgttgccg ctcgcggact tgatatctca ggtgttacac acgtatacaa 512101 cttcgacgtg cctcaagatc ctgaaagcta cgttcaccgt atcggaagaa cgggccgtgc 512161 aggaaaaaca ggtatggcga tgacgttcat tacaccgcgt gagaaaagca tgcttcgcgc 512221 aattgaacaa acaacaaaac gcaaaatgga ccgcatgaag gagcctacac ttgatgaagc 512281 gttagaaggt cagcaacagg ttactgttga acgtcttcgc acaacaatca gtgaaaacaa 512341 cctgaacttc tacatgacag cggcagctga gctgcttgaa gatcatgatg cagtaacagt 512401 ggttgcggcg gctatcaaaa tggctacaaa agagccagac gacacaccgg ttcgcttaac 512461 agacgaagcg ccgatggtca gcaaacgcta caagaaccag cgctcttcta aacgcagaga 512521 cggtcaaggc ggcggctacc gcggcggaaa agggaaaagc aacaaccgtt cttcctatga 512581 caaaaagcgt tcaaacgatc gccgttcttc aggtgacaga cgccagaaaa aatcttacta 512641 atttgatcga ttcagagccc aaaacatgat gttttgggct tttttatgtt cgtgatttgt 512701 tattcagcaa actttcagct gacggaagcc atttttctct gtatgcttaa gaatgaaacc 512761 tttctgtaaa agagacgtat aaataacgac gaaaaaaagg gaggtaggta tttttgagag 512821 agcagccaaa aaaccaaatc agtccagacg gattaaaggt ttggcgactt caagagatca 512881 tcatatccgc tgtttgcttg cttattgtca ttgcagttgc agtgttaagc tattattttc 512941 attggccgta ctggatcagc ggcgtgctcg gcgctgtttg gctgctggga tcgattgtga 513001 cggtctttat cattccgaag gtccgtcata aggtgtggcg atatgaagtc catgaacatg 513061 aaatagatat tcagtcaggt atttttgtgg tgacacgtgt gattgttccg atggtcagag 513121 ttcagcacgt cgatacgtca caagggccat tattaaaaaa atacaacctg gcaacggtga 513181 aaatttccac agccgcgacc gttcattcga tccccgcttt agagatggag gaagcggatc 513241 ggctaagaga ctccatttcc cgtctggcga gggtgactga cgatgatgtc tgaaccgaaa 513301 cgcctgcacc cggtggcagt cattttgaat ttatgccata ccattattca aacgataaaa 513361 aatatcattc tgccattctt ttttgtgtat attgtcaatt caaaccatac tgtccgtttt 513421 tacggagcca ttgcgctcgg tgtgctgttc atctggcttg tagcggcaag cattatcaaa 513481 tggagaaggt ttacctatcg aattgaagat gatgaattta gaattgaaga aggcttattt 513541 gttacgaaaa aacgatacat atcgattgat cggattcaaa caatgaatac gagcgcgggc 513601 cttgtccagc aaatctttaa gcttgtgaag ctgcaaattg aaacagcagg cggaggcaag 513661 gaggcagaag ccgttctttc tgctatttct gttgaagaag cggaacgcat caaagaagct 513721 gtctttaaga aaaaagcgca aagacgagaa aatgaacttg atgaagaacg gcttgaagct 513781 gaagaggagt tggatccgtc cgttgaggtg caagagcact atcgcatgaa cgcgaaagaa 513841 ttgctcatgg ccgcttctac ctccggcgga atcggagtca ttatctccgc tgtatttgca 513901 cttatttccc agcttgatga agtgctgccg atggattggt tattcgataa attttccttc 513961 cttcagcacg ccagcatcgg tatttatgcg gtactcattt ttatcggttt atttatcgcc 514021 tggattttca gcatcgcggg catgatgttt agatacgcga actttcaaat cataaaaaaa 514081 gagcaggaac tggtgatttc aaggggaatt attgaaaaac atcaagtcac gattccgctg 514141 cgaaaaatac aagccattaa aatcaaagaa aatatcattc gccagctttt cggctttgta 514201 acggtgtcca tcgtcagcgc aggaggcggc gaccgggaaa aagaagaagg cgctttgacc 514261 attctctttc caatgattca taaaaaaaag cttccgcaca tgctccgaac atttacgccg 514321 gaatacacgc tggaagaaaa ctgccgccgc ctgccgcggc gcgcgttgaa acgctatttg 514381 ttccgttctg tcattttttc actctttttg atcatcccgt tatgtatctt ctttcagcca 514441 tggggctatc tgtcagtgat cctgctgccg atagaattgc tcttcggcta tctcgcgtat 514501 aaagaggctg catggacgat caacggggac cgtcttcagc tgacgtctag atttataggc 514561 agaacaaccg ccattgtact gaaaaaacga atgcaggtct gcaagttcag ccaatcctat 514621 ttccaaaaga aaggccgctt gtataccatt tctacttcgg tgaaatcatc gagccatatg 514681 gaagagttaa cggtgaggga cgtaggtgaa gaggatgcag ccttcatttt aaagtggtac 514741 tcatatgaaa aagcggacgg ttaataccgc cgctccagcg tgtcggcaaa ccctcgcatt 514801 cgttgtcagg actgcgcttc ggtgctcaat gcgaagtgga tcaacggcta aattctcagg 514861 cgtcctgcct aaacgccgtc gtcatcacat cctgtgaaag tccgctccta tgctcgtcct 514921 tcctagactt catgggtttt caatcacgct gaaaagatga caaaatccta aaatgaaaac 514981 cattttagga ttttgtcaac aatctgaagc ggcggttaat accgccgctc ttttttttgc 515041 acgcataaaa acgaaagaag aaacccgccg catagtccaa acaaatgggc catcatgtta 515101 atattggagt tgataaacga catgagaacg gcaaatgcga gcagtgtgat gatcattttg 515161 gaatgctcct gcccaattaa ctcattgcga aaaagaacca taaacaggta tacgccaaat 515221 agcccgaaaa tggcgcctga agccccgaca tgcacgtaat caagcggctc tgtaacataa 515281 gtgccgatat tgccgatgat gccggagccg gcgtatacaa gaaggaaacg cgcttttccc 515341 agcatgcgtt ccaaagccgg ggcaaataaa aagatggaca tggaattaaa cagcagatgt 515401 gtgaaaccgg cgtgcagcaa aatcggtgtg ataagccgcc accattcacc gtttgcgaca 515461 cctagattat agcctgtgac ggtatccctc cataacacga ctgaatgggc aggaagtgaa 515521 aaaaacagcc agagaacagc ttgcaaagcc aatataaagg tgacaacggg gtaaagcctg 515581 ataaatgttt gaaaattttc agtccgtata aacattccga gccccttttc ttcattttgg 515641 tatatctata gtaacacgtt tatgagacaa accatttaaa tagtacgtac gcaaaggagg 515701 ttatcataca tgatttacgg cattgggctg gacattaccg agcttaaacg gatcgcctct 515761 atggctgggc gccagaaaag gtttgccgag cggattttga cgcgaagcga gcttgaccaa 515821 tactatgagc tttcagagaa aagaaaaaac gaatttctcg cgggcagatt cgcggcaaaa 515881 gaagcgttct cgaaagcatt tggcaccggc attgggaggc agctcagctt tcaggacatt 515941 gaaattagga aagaccaaaa tggcaagccc tatatcattt gtacgaaact gagccaggcc 516001 gccgttcacg tatcgatcac tcatacaaaa gaatacgctg ccgcgcaggt tgtgattgaa 516061 aggttgtcaa gctagtctgc atattaggga aaccccactc atatatttga tagtgcatta 516121 agggagacaa gttgtttgag gcttttatgg tacgcatctg ttctgcctaa acgtgtaccg 516181 agcgtaccgt taaagtcaaa caagcgattt cttcctttta catcaattga gaaaaagggg 516241 ttgaaaaagg tgagaaaaag ctttgttttg cttttaacgg gactgcttgc tgttcttatt 516301 ctttctgcct gcgggcaaaa aacacagcaa gatattgtgg ccgggttaga tgaaaaggcg 516361 aaagaataca cctcgtacaa agcaaaagcg aaaatgacca tcgagacagg gagtgagcct 516421 caagtataca atgtggaaat ctggcacaaa aagccgtctc tgtacagggt ttatttagaa 516481 aatccgaaaa aggaccaaaa ccaagtcatt ttacgaaatg aaaacggagt attcgttctc 516541 acgccgtctt taaataagag cttcagattt caaagcgatt ggccgaacaa cagcagccag 516601 gtttatctgt ttgaatcgct cgtaaaggat gttcaaaacg attcggatgc agttttcaca 516661 gcgaaagaaa agaaatacgt atttgaaaca aaaacaaact atcagcataa caaaatgctg 516721 cccacgcaag aaatcacatt taacaaaaaa gatatgagcc cgtcatctgt caaagtgatg 516781 gatactgacc ggaaagtgat ggtcaaagta gaattcagca gctttgaatt taataaacaa 516841 tttgataaag aatcatttga tgaaaagaaa aatatgaccc tttctcaaat ggatgtcgcc 516901 acaagcgcaa agccttccga tacatttgcg gtcaaaacgc cgctggaact gccgcttggc 516961 gtcaagctgc ttgaagaaaa agatatatct actgaagacg ggaagcgcat catcatgacg 517021 tacggaggag aaaaatcatt tacgttaatt caggaaaaag cccagattgc caaggcttcc 517081 tcctccgtta cgctgaacgg cgaaccggta aatctcggct acaccatcgg cgccctgtcg 517141 gatgcatcat tatcatggac atatgacggc gtagattacc ttctctcttc taaagatctt 517201 tctaaagagg aaatggtgac agtagcgaaa agcatgcagg gacaatcatc gaaataaccg 517261 ccaaaggcca aacatgattt ggcctttttt tcgttagaca tcgtttccct ttagccttta 517321 attttagtat gatatgtaaa tgatattgaa taaaagctag gaagtgtcgt aatgagcaca 517381 aaaccttttt acagagatac gtgggcggaa attgacttgt ccgcgataaa ggaaaatgtc 517441 agcaatatga aaaaacatat cggtgaacat gtccacttga tggcagttgt gaaagcaaac 517501 gcctacgggc atggtgatgc agaaacagca aaggctgctc ttgacgcagg tgcttcatgc 517561 ttggccgtgg ccattttgga tgaagcgatt tcactgcgca aaaagggatt gaaggcgcct 517621 atattggtgc ttggcgcggt tcccccggag tatgtggcaa tcgctgctga gtatgacgtg 517681 accttaacag gttattctgt tgaatggctt caggaggcag cccgccacac gaaaaaaggt 517741 tctcttcatt ttcatctgaa ggtcgatacg gggatgaaca gacttggtgt aaaaacagag 517801 gaagaagttc agaacgtgat ggcaattctt gaccgcaacc ctcgtttaaa gtgcaaaggg 517861 gtatttaccc attttgcgac agcggatgaa aaagaaagag gctatttctt aatgcagttt 517921 gagcgcttta aagagctgat tgctccgctg ccgttaaaga atctaatggt ccactgcgcg 517981 aacagcgccg ctggactccg gctgaaaaaa ggctttttta atgcagtcag attcggcatc 518041 ggcatgtatg gccttcgccc gtctgctgac atgtcggacg agataccgtt tcagctgcgt 518101 ccggcattta ccctgcattc gacactgtca catgtcaaac tgatcagaaa aggcgagagc 518161 gtcagctacg gagccgagta cacagcggaa aaagacacat ggatcgggac ggtgcctgta 518221 ggctatgcgg acggctggct ccgaaaattg aaagggaccg acatccttgt gaagggaaaa 518281 cgcctgaaaa ttgccggccg aatttgcatg gaccaattta tggtggagct ggatcaggaa 518341 tatccgccgg gcacaaaagt cacattaata ggccggcagg gggatgaata tatttccatg 518401 gatgagattg caggaaggct cgaaaccatt aactatgagg tggcctgtac aataagttcc 518461 cgtgttcccc gtatgttttt ggaaaatggg agtataatgg aagtaagaaa tcctttattg 518521 caggtaaata taagcaatta acttacctaa atggagaatt cataaaacag ctttgcttga 518581 agagtgaata atggtatcat tatcactgga tggataaaag agtcgtatcc gtaagtttgg 518641 tggaggtgta tgttttttgt ctgaatccag cgcaagaacc gaaatgaaaa tcagcttgcc 518701 cgaaaaccta gtagctgaat tggatggtgt agcgatgcgg gagaaacgaa gcagaaacga 518761 actgatatca caagcagtga gagcgtatgt cagcgaacga acaactcgtc acaaccgtga 518821 tttgatgaga cgcggctata tggaaatggc gaaaatcaac ctgaatattt cttctgaggc 518881 tcactttgcg gagtgcgagg ctgaaacgac agttgagcgc ttagtcagcg gaggataatc 518941 atttgattgt gaaacgcggc gatgtttatt ttgctgattt atctcctgtt gttggctcag 519001 agcaaggcgg ggtgcgcccg gttttagtga tccaaaatga catcggaaat cgcttcagcc 519061 caactgctat tgttgcagcc ataacagcac aaatacagaa agcgaaatta ccaacccacg 519121 tcgaaatcga tgcaaaacgc tacggttttg aaagagattc cgttattttg ctggagcaaa 519181 ttcggacgat tgacaagcaa aggttaacgg ataagattac tcatctggat gatgaaatga 519241 tggataaggt tgatgaagcc ttacaaatca gtttggcact cattgatttt tagacatatt 519301 tgcaggttgc tcaaatagag caactttttt tgttttcaaa aaacataaac gatataatag 519361 tgaaataacg aaaaaatatg ttgtttttta ttgggaggta agcgaatttg atgtcgaacc 519421 agactgtata ccagttcatt gccgaaaatc aaaatgaact gctccaactg tggactgaca 519481 cactaaaaga attaagcgag caagaatcct atcagctgac tgaccaagtg tatgaaaata 519541 tatctaaaga atatatcgac attctgctgc tgtctgttaa ggacgaaaat gctgctgaaa 519601 gccaaatcag cgaactggcg cttcgagcgg tccaaatcgg actgtctatg aagtttttgg 519661 ctactgcact tgccgaattc tggaagcgtc tctacacgaa aatgaatgat aagagattgc 519721 cagatcaaga gagcacggaa ttaatctggc agattgatcg ctttttcagc ccgattaaca 519781 cagaaatttt taatcaatac tcaatctcat gggaaaaaac agtatccctg caaaaaatcg 519841 cgctgcaaga gctgtctgcg ccgcttatcc cggtgtttga aaatatcact gtgatgcctc 519901 ttgtcggaac aattgatacc gaacgcgcga aacgaattat ggaaaacctt cttaatggcg 519961 tcgtcaaaca ccgttcccaa gtcgtgctga ttgacattac aggtgtccct gtcgtcgata 520021 cgatggttgc ccatcatatt attcaggcat cagaagctgt aaggcttgtc ggagcaaaat 520081 gcctgctggc cggaatccgt ccggaaattg ctcaaacaat cgtcaacctg gggattgatt 520141 tatcccaagt tataactaag aataccctgc aaaaaggaat tcaaacagca ttggaaatga 520201 cggatcgaaa aatcgtttca ttgggggaat aacattttga gacatccgaa aatcccgatc 520261 ttgaaactgt ataattgctt attagtgtcc attcagtggg aacttgatga ccagacagca 520321 ttaacttttc aagaagactt attaaataaa atatacgaaa caggtgctaa cggagtcgtc 520381 attgacctga catctgtgga tatgattgat tcatttatcg cgaaagtgct gggggacgtc 520441 attacaatgt ctaagttaat gggggctaaa gtcgtcttga ccggcattca gcccgctgtg 520501 gcagtgacgc tgattgaact tggaatcgcg cttgaggaaa tcgaaactgc gctcgactta 520561 gagcaggggc ttgagacatt gaagcgggaa ttgggggaat agcgaatgaa cgaccaatcc 520621 tgtgtaagaa tcatgacaga atgggatatt gtggccgcca gacagctggg acgaaacgtt 520681 gcgaaagaac tgggtttcgg cacggtagac caggctagaa ttacaacggc tatttcagaa 520741 ttagccagga atatttattt atatgccggc aaagggcaga ttggaattga acaggtcgca 520801 gacagaggaa aaaaaggcct gaaaatcata gcggaagacc aagggccggg aattcctgat 520861 atccgaaaag tcatggaaga cgggttttca acgtctggag gacttggtgc gggacttccc 520921 ggggtcaaaa ggctgatgga tgaattcagc ttaaattccg tagcggggga aggaacagag 520981 atacaagcca tcaaatggct tcggtaggag gtaagaacgt ggattttagg gaggttattg 521041 agcagcggta tcatcagctg cttagtcgat atatagccga attaacagaa acatctttat 521101 atcaagccca aaaattcagc cgaaaaacaa tcgagcacca aattcctccg gaagaaatca 521161 tcagcattca cagaaaagtg ctgaaggagc tgtatccaag tctcccggaa gatgtgtttc 521221 attcgctgga ttttttaata gaagtcatga ttggctatgg aatggcttat caggagcatc 521281 aaacccttag agggatacag caggaaatca aatcagaaat tgaaatcgcg gcaaatgtcc 521341 agcagacgct tctcggaact aaagttcctc aggaggaagc gctggatatc ggcgccatca 521401 gtgttcccgc taaacagatg agcggtgatt actaccactt tgtcaaagac aaggaatcca 521461 tcaatatcgc aatcgcggac gtgatcggaa aaggcattcc agcggcttta tgcatgtcca 521521 tgattaaata cgcaatggac tctttgccgg aaacgggcat acacccttct caagtgctga 521581 aaaatttgaa tcgtgttgtt gaacaaaacg ttgatgccag tatgtttatt acgatgtttt 521641 atgcgaatta caatatggac aagcatcaat ttacatatgc ttcagcggga catgaaccgg 521701 gattctatta ttctcaaaaa gacaacacgt tttacgattt agaggccaaa ggactcgttc 521761 tcggcatctc gcaggactat gactacaaac aattcgatca gcatctggaa aagggcgata 521821 tgattgtttt attttctgac ggcgtcacag aatgcagaac ggaaaacggt ttcttggagc 521881 gtcctgatct gcagaagctc attgaggaac atatgtgttc ctctgcgcag gaaatggtca 521941 aaaacattta tgacagcctc ctcaaattgc aggattttca gcttcacgat gattttacgt 522001 taattgtttt gcggagaaag gtttaacgtc tgtcagacga gggtataaag caactagtga 522061 tttgaaggaa aatttgaggt gatacgaatg aatataaatg ttgatgtgaa gcaaaacgag 522121 aatgatatac aagtaaacat tgcaggagaa attgatgtat actcagcccc ggtgcttaga 522181 gagaagctcg ttcctctggc agaacaagga gctgacttaa gaatttgcct gaaagatgtc 522241 agctacatgg acagtaccgg attgggcgtt tttgtaggga cctttaaaat ggtgaaaaaa 522301 caaggtggtt cgctgaaact tgaaaatctt tctgaacggc tgatccgact gtttgacatt 522361 acaggcttga aggacatcat tgatatttct gcaaagtcag aaggtggagt gcaatgaaga 522421 ataatgctga ttacatcgaa atgaaagtgc cggcccaacc tgaatatgtg ggaattataa 522481 gactgacgct gtcaggggtc gcaagcagaa tgggctatac gtacgatgaa attgaagact 522541 tgaaaatcgc agtcagtgag gcgtgcacaa atgcggttca gcacgcttac aaagaagata 522601 aaaatgggga agtgtcaata cgattcggtg tgtttgaaga ccgtttagag gttattgtgg 522661 cggatgaagg agacagcttt gactttgatc aaaagcagca ggatctaggg ccgtacacac 522721 cttcgcacac agttgatcaa ttatcagaag gagggctcgg tctatattta atggaaacgc 522781 tcatggatga agtcagagtg caaaaccact ccggcgtcac cgtagcgatg acaaagtatt 522841 taaatgggga gcgagttgat catgacacaa ccatcaaaaa ctacgaaact aactaaagat 522901 gaagtcgatc ggctcataag cgattaccaa acaaagcaag atgaacaagc gcaggaaacg 522961 cttgtgcggg tgtatacaaa tctggttgac atgcttgcga aaaaatactc aaaaggcaaa 523021 agcttccacg aggatctccg ccaggtcggc atgatcgggc tgctaggcgc gattaagcga 523081 tacgatcctg ttgtcggcaa atcgtttgaa gcttttgcaa tcccgacaat catcggtgaa 523141 attaaacgtt tcctcagaga taaaacatgg agcgttcatg tgccgagacg aattaaagaa 523201 ctcggtccaa gaatcaaaat ggcggttgat cagctgacca ctgaaacaca aagatcgccg 523261 aaagtcgaag agattgccga attcctcgat gtttctgaag aagaggttct tgaaacgatg 523321 gaaatgggca aaagctatca agccttatcc gttgaccaca gcattgaagc ggattcggac 523381 ggaagcactg tcacgattct tgatatcgtc ggatcacagg aggacggata tgagcgggtc 523441 aaccagcaat tgatgctgca aagcgtgctt catgtccttt cagaccgtga gaaacaaatc 523501 atagacctta cgtatattca aaacaaaagc caaaaagaaa ctggggacat tctcggtata 523561 tctcaaatgc acgtctcgcg cttgcaacgc aaagctgtga agaagctcag agaggccttg 523621 attgaagatc cctcgatgga gttaatgtaa tgatccaggt tgaagaaaac gagcatattc 523681 aaactctagt atatcaactg aataaagaag ggaaatcgat ttgcggtgac agttttttta 523741 tgaaagctga tgataaggag ttaatttgcg cggttgctga cggactggga agtggatcac 523801 ttgctaacga atcctctgca gccatcaaag acttagtgga aaactatgcg agtgaagacg 523861 tagaaagcat tatcgaacgc tgtaatcagg cgatgaaaaa caaaagaggc gctacagcat 523921 ctatcctgaa aatcaatttt gagcaaaggc agtttacgta ctgctctgtc ggaaatgtac 523981 ggtttattct gcattccccg tctggtgaaa gcttttatcc tctgccgatt tcgggctatt 524041 tatcaggcaa gccgcaaaaa tacaaaacgc acaccgccac ctatgaaaag ggttcaaagt 524101 tcattataca tacagatgga ctcaacgtac ctgatatccg ctcccatttg aaaaaaggcc 524161 aatcggtaga agaaatatcg aattcgctga aaatgtatac gacatcgaga aaagatgacc 524221 tgacctatat tctcggacag ctgtcctaaa aaaccagaaa aagaagctgg acatccggct 524281 tctttttttt gcggttgact attaataagt gcgcttatta taattaataa gtgaacttat 524341 cattctggga gcttatggga tgtggaatta tgaatacaca gcgatagctg atgtggatgt 524401 gggaaaacct ggaactgtta tcaggaaaca gaaacaatgg atcaatggga gacgggtatt 524461 gcatcagatt ctttgaaagg acaatttcaa aatggaacgg aaggaacatt gcttctgcaa 524521 ggaaaaacaa ttctcttatg gcttgagcat gtggagaaac atcgggcgtt ttctgtcatg 524581 gtcaacatgc ccgcatagca atgtaataat ggagtttttt cacgtgcttc aaaagcaaaa 524641 agaagatttg tgtatcacat atggaattgt attagaaggc gctgaagcaa aaaagtgggg 524701 agaaatcatt gggactgaac tgtctaaaga catgccgacg gctgtcagca ggcttgtcca 524761 tctttacgga ggagtgataa aatgaacaca aattactgga tcggcgttgt gtcagagcaa 524821 catgtattaa aaggcgctgc cggcggtttt gcacagctgt gccatggaaa aaaagccccg 524881 ctcgccaaaa tgaaagaggg agattggctg atttattatt ctccgagaga cgcatatcca 524941 gacggcaaac tgctgcgaag ctttactgcg atcggcaaag taaaaagcgg aaacatctat 525001 ccgtatcaaa tggctccgaa ttttattcca taccgattag atatagacta ttatccatgc 525061 cataaaatcg gtttttacga cattaaatca aagcttgaat ttgttcagga aaccaagcat 525121 cttggctttt tatttcgcag aggacacttt gaaataagca aaaaagattt tttgacaata 525181 gcacaagcga tgggagttaa cataagtgga atggcactct aaatttagcg gtccgaacac 525241 aagcccgggc tttttattat ggcaggccac gcaaagttgg cagcggaaag taggaaaagc 525301 attggctgag tttgacctga cccacgttca atttgttctg ctgacctcgt gcaagtatat 525361 gattgctcac ggagaaaccg tcacgcaaaa aaaacttgca agcttcagcc agaccaatat 525421 catgatggtt tcggaggttg tgcggacgct tgagaaaaaa ggatttatcg aaagaagcaa 525481 aaatccccag gataaaagag aggtcctcct gtctcttaca gaaataggag gagaaaaagt 525541 aacagcggct ttgccaattg ttgagaagat tgatcaagcc ttctttgcag ctgcgatgaa 525601 aaaagagaat tttctgagcg gcttacagga actattgaaa catgagtaaa gatacgggca 525661 gcgccagctg tcttttttta tgtgtttttt tcggtttttg atacactaga gaaagaacga 525721 caaaattgga ggctttggtt acatggaaac gtcagccctt ttaaaacagc aaattgcgaa 525781 agaaataggt ttatcacaaa aacacgttga aagtgtcatc cgcctgcttg aggacggcaa 525841 tacagtcccg tttattgccc ggtatcgaaa agagcagacg ggttcaatgg atgaggttca 525901 gattcagacg atttctgaac gctggcaata catacaaaac ctgaatcagc gaaaagaaga 525961 agtcatcagg ctgattgcag agcaggataa actgacagat aatctaaaac gtaaaatcga 526021 gcaatcggtg aagcttcagg aagtggaaga cctttaccgc ccttataaac aaaaacgtaa 526081 aacaaaggcg acagtcgcca aaagcaaagg ccttgagccg cttgccgact atatcctgac 526141 acttccccaa gatgatcatc tggcagcaac tgcagaccaa tacatcagcg aagaaaaaga 526201 agtgttcaca cgagaagaag cgattgaagg cgccaagcac attattgcgg aacaaatctc 526261 agacgagccg accttcagaa agtggattcg ccaggaaacc ttcaaaagag gaaccattaa 526321 gtctgcagcc ggaaagtcgg cagacaccga tgagaaaaat gtgtatgaaa tgtattacga 526381 gtatgaagag ccaattgcaa aagttgttcc gcatagggtg ctggcaatga accgcggcga 526441 aaaagaagac attttaaagg tagcgatcga accgcctgcg gatcacatta aggcgtattt 526501 agaaaaacaa atcatcaaaa atcgctcaac atccgtaaga gagattttgc aggagacaat 526561 tgaagacagc tataaaaggc tgatccagcc ggcaatcgag cgtgaaatca ggaaagagct 526621 ctcagaaaaa gctgatgaac aggcgattca tattttctca gagaacttga gaaagcttct 526681 tttgcagccg ccgatgaaag gcaaaaccgt tctcggtgtt gacccagcct ttcgaactgg 526741 ctgtaagctc gctgtgtcag atgagaccgg aaaagtcttg aaaattgatg tgatctatcc 526801 gcatgcgcca gtcaacaaaa caaaagaagc ccatgaaaaa gtgaaaaaga ttcttgagca 526861 gtatcaagtc gagatggtgg cgatcggaaa cggcacagca tccagagaaa cagagcaatt 526921 catcgtcaat gtactcagag acatgccgcg caaaatttat tatgtgatcg tcaatgaagc 526981 gggagcaagc gtctattcgg cttcagagct tgccagagaa gaattccctg accttaaggt 527041 tgaagagcgc agtgccgtat ctattgctcg gagacttcaa gacccgctcg cggagctcgt 527101 taagatcgat ccgaagtctg ttggtgtcgg acagtatcag catgacgtca gccaaaaacg 527161 cttaaatgaa tctctgcggt ttgtcgtcga aactgtcgta aaccaggttg gagtaaacgt 527221 caacacagcc tccgccgcgc tgcttcaata tgtagctgga ttatcgaagt ctgtagcagg 527281 caacgttgtc aaaaaacgtg aggaaatcgg aaagttttca aatcgaaaag aactgaagga 527341 catcccaagg ttaggtgcga aaacctatga gcaatgtatc ggtttcttaa gagtgcagga 527401 agggacagag cctttggata gaacaggcat ccacccggaa agctataaag aaacaaaagc 527461 acttttgaaa aaactcggac tttcaacaga acatatcggc acggcggaat tgaaggacaa 527521 aatcaatcag ctggcgctct ctgaaacggc aaaagagctg ggaatcggcg aaatcactct 527581 gaaagacatt tgtgaacagc tgacaaggcc ggaacgcgat ccacgcgata aggtgcctaa 527641 gcctttgctg aaaacagacg tccttcagct ggaagatttg aaagagggaa tggaactgca 527701 gggcaccgtg cgcaatgtag tggacttcgg agcgtttgtt gatatcggag tcaaacaaga 527761 cgggcttgtg catatctcaa aattgagcaa tcaattcgtc aagcatcctc ttgatgtcgt 527821 atctgtcggc gatattgtga cagtttgggt tgacggcgta gatgtacaaa aaggcagagt 527881 atcgctgtct atggtaaaat aaaagcactg cttacgagca gtgttttttc ctatagaaat 527941 accagcattg attcagcagt ttaatttggt aattatcttt ttcaaggaac gctttttgca 528001 tctgcttttt aagccaattt ggcataggct cattcctcct cagcttttat cataagaggg 528061 acagtgatta ccatattgta tgcgaacggt gaattgtccc gttcaatgtt ttttaagtga 528121 ggtgcaccat ggataacaaa gagcttcaaa agctgacaga ggatatttct gaaacatatt 528181 ttaaaaagcc gttccgccat caggcgcttt ttaatgaccg gcttaaaacc actggcggca 528241 ggtacctgtt aacctcccat aacattgaat tgaacagaaa atatttgatt gaacacggca 528301 gggaggaact gattggcatc atcaagcacg agctctgcca ttatcatctt catcttgaag 528361 gaaaagggta caagcacaga gacagagatt ttagaatgct attgcagcag gtcaacgcgc 528421 cgaggttctg tacacccctt aagaaaaaag cggaaaacaa aaaaacttat atgtatatct 528481 gtacgacctg cggccaacag tatataaaga agcgcgccat gaaccctgac agatacagat 528541 gcggaaaatg ccgcggaaaa ataaaaagaa ttttttcgtg aaaaaggttg acgaatatgg 528601 caagcctatg ttacattata aaagtcgtca cgagagataa ataaaaacat ttacctcttg 528661 acactgcaaa tcaaggctga tataataagt cttgtctcat tattccacag tagctcagtg 528721 gtagagctat cggctgttaa ccgatcggtc gcaggttcga atcctgcctg tggagccata 528781 ttggagaagt actcaagtgg ctgaagaggc gcccctgcta agggtgtagg tcgcgtaagc 528841 ggcgcgaggg ttcaaatccc tccttctccg ccataagatt tcgatataag ttctcaacca 528901 tcggcccgtt ggtcaagcgg ttaagacacc gccctttcac ggcggtaaca cgggttcgaa 528961 tcccgtacgg gtcattccat ttcgttgggc tatagccaag cggtaaggca acggactttg 529021 actccgtcat gcgttggttc gaatccagct agcccagcca tttttatttt tgaaatctaa 529081 tagtaagagc cattagctca gttggtagag catctgactt ttaatcagag ggtcgaaggt 529141 tcgagtcctt catggctcac catttgtctt tttgcgggtg tggcggaatt ggcagacgcg 529201 ctagacttag gatctagtgt cttacgacgt gggggttcga gtcccttcac ccgcacttta 529261 tttacaaagt gcacgcaaat ctgttttact aggttaagag cctactaaac cagcacaaca 529321 caatttaatg atcacgcggt cgtggcggaa tggcagacgc gctaggttga gggcctagtg 529381 ggtgaataac ccgtggaggt tcaagtcctc tcggccgcat caatgatacc aagggttttg 529441 acacccttgg tatttttttg tgtttatttt caaatgattt actgcccaca aactgcccac 529501 ttacctaaag taagtcatct aatttatcag ccatttcctt ttgcttgttt ggatataggt 529561 gtccataaac atcaattgtt gtttttacag aaccatgtcc taaacgctct ttaattgtta 529621 tgtaatcttc tccttggtgt attaatagtg caacgtgtga atgtctaaaa tcatgtaaac 529681 gtataggagt aagatcgcta tccttgcaaa agtatttaat tttccgactg aaaatatctt 529741 ttcttgaagg tgtatcttta tattgaaaga tataggtatc atgtgaatgt ctaataccta 529801 attcattaaa caactcttct tgtgcttctt tccaacgttc tagtagctta agcaattttt 529861 tattgatgct aactcgccga atcgaatttt tagtttttgg agtagtaaca acaaattgac 529921 catcaagcca ggtgcacgat ttatgcacat ctatttctaa taagattttg tcaatatctt 529981 tccattgcag ggcgagcatt tcaccacatc ttagtccagt taaaaaagca acagtgtaaa 530041 aggttttaaa caataattga tcttgaggaa ttaaactaat aaattttttg aattcttctg 530101 gtctccaaaa cttcattttc tttcttgtta aaggtaatcg tttaacgttg tcacacggat 530161 ttctttttaa gatttcttca tgtacagctg tatcaaaaat tttgcttaga ctagtcatta 530221 tattattaac cgatttattg cttagacctg tttccattaa atgttttctg aaatcagtta 530281 tttctctatg tgtgattttt tgtatatcag atttcaaaaa gtaatcagat atatgtttgt 530341 ttataatgta cttctgattc tgataatagt ttggtttact atctatttca caacttgcta 530401 aataaattga aattagagtc ggaaagctta ctgatctgga ctttcttgct ctttcttctt 530461 gaaattctct tcttaatttt gcttctaatt ctaaagcctc ttttctggtt gatgctactg 530521 gtctcgtcct aattctttct ccagtaatcg ggtcaaatcc aaagctaacg tcaacttgat 530581 attgaccatt ttcaagtttt tttacagaca ttttatttct cctttaacca aaagcgctta 530641 tttcgtgtga atagattctg ttactaaatg agccaatttg agaaagttta taatcagtaa 530701 caaatgatgg tacgttgaag tatgctgcta tttgttcttt gctaaaaccc tgtatatatg 530761 gaagggcttc attaagcatt ttatctgtca gtattaattc tgatgcaaat aggcttgctt 530821 gatgctcaag tttatctttt agaactttag agcaattcac aactttaaaa gtgttcaatc 530881 ttttatggag aaagtaatgc cctaattcat gggcaattac aaattgttga tgttggaggt 530941 tctcgttgat atggattaaa tattgatctg tggctttgtc atgttgtagt aaaccgtttg 531001 cttgtccaag atcatttttg agtatataaa ttttttggat gtcacaaatt tcatagacat 531061 tatttgtacc atgtgtctta attactgatt gcactttatg tttaattcct ttgcttgtat 531121 aaattgttat cactctttct tctttaattc gtcaatgaat ttaattccgt tttttaatgc 531181 ttttttaaca aggcgtgcag tttcctcatc aaattcacca tcattcataa aaaggagtgt 531241 atcttcatcc tttaattcct gtatggcttc attaattgtt ttattgagta aatcagtttc 531301 gtttttcttg cttacttcat cctttcctaa taaatagtct gtagatacgt tatataagtt 531361 gctcaatttt aagagtgtgt ctgtatcagg atctctgtaa tctctttcgt aattagacaa 531421 gttattgtta ccgatattaa gtttctctgc ggcttctttc tgagtgtacc cagctttttg 531481 tcgagcttct tttaatcgtt tgcctaggct catttttatc atccatttca caaagagttg 531541 atttttataa aaataataac aacatttttt ggagaattca ttaatttcac ctataagtta 531601 aataaataat tctaaattct ccttttagga gtgtttgttt cttctttatg gagagtttaa 531661 ttatcaatat ttccatatat gttcaaaaaa atacacttta aggtgaattt tgtgttgact 531721 tacacgaaaa ggagttttat aataaagtta attcacaaag agttgagtta acgaggaggt 531781 gatattttga aaggagagtt tttaactgcg agagatattc aaaaaattct tggagttaaa 531841 caggctaaat cttatgacat cattagaact ttgaatgctc aaatgaaaga agaaggatat 531901 atggtcattc aaggtaaggt gagtagagct aagtttgaag agtgttattg ttacaaaggc 531961 ccaaaatctc aaacggggtg atttttataa acattgatat aacaaactcg tttatgaaag 532021 aagctgtccc tttagctaga caaatggaag gtgattggat agcacgaatg aaaattgctc 532081 tgaattcagt cattataaat cattatttaa accttccctt aacaattgaa aatgttaatg 532141 aattactgcg aaaaggcgtt tcatatcgca ggatatgtaa gcattacggc attggaagaa 532201 aagacattga aaagcttcgg caatcatccg tagtgtgacg ttatatacca ctatagggag 532261 ccgttaagaa tcctttgaaa ggagggatgc gatgaaaata agagtgaatg caacaatcat 532321 tactgatgtt gaagctttaa aggctgataa ggatttgaat cattttaaag actatgccac 532381 ttgtgaaaca ttcgttgttg atgctgataa tcatttgaag gctaatgaag aaatatctga 532441 gttgttaaaa ggctgggatt ggtggtgtat ctggtcaact cgtccattga gtaaaaagga 532501 taaccaagtg tttactttgt ataacgatga tttgtataac ttatgtcgat aggagtgttt 532561 gttccttgaa aactacatat agacaaaaaa agcgccttga cgaatgatca tcaagaacgc 532621 cggaaaataa aaactagaca cttttattat acggtattct tgttgaaatg tcatgcgtga 532681 gtatttgagt gatgaacagc aatcacttta aatgctgtag caggctagaa taagcgtgcg 532741 gaatagctgt agtcagcttg atggctataa ttagcctact aggttgccat gagggcgtaa 532801 agccgttagc aactgataag cgccaagatg gatacagaac cggagcgaat caaaaacata 532861 aaatcgaaat taatgttctt ttgtaaataa attataaaaa aatgaaatgg ggatatgaaa 532921 aatgaactta aactttattg taccggatat caatatgact tttggagaca tgaaattcat 532981 gggacttaac agagaaaggt atgtttatga tcgtgaaaat aataagcgta ctgacgtact 533041 ggaatctagg atttataaca ttgctagtgc tgtccaaggt ggtcaaattg aagtaactat 533101 tcctgagtat gctggggcaa aagaaattcc tccttttgca gatattgagt tgaaaaatcc 533161 aaaaattagc gctatggcga ctagtcaaag ggattcgacg tatgccaatg tgatgtggaa 533221 acttgaagct gatgatattg ttgttaaagg tggctcttct gtgaaacctg ccgcggcaac 533281 tggcgggaat gaaaagaaat aacatgatgc tctcatatcg gcaggcgggt gatgtatatg 533341 agtgatttct taaacaaaag attttggaaa tacaggggca aacgaatccg cccgtacatg 533401 agaaacaacg taaagttagc aggcgcaatc atctttgtgc ctgttttttt attgtctatg 533461 ttcctttttt ggagagaaca actcattcat tttgatctat ctcaagtgat aaaaaatttt 533521 gaatggaatg tgcctttaat cattaaaagc gttttatgct ctgtgctaat tgctgttgga 533581 agcatagttg catcttactt tcttttgttt gacagctata agaaaatcct tcacaggcaa 533641 aagattgcta aaatgatttt ctctaacaag ttttacgaaa aagaaaacgt gaaagtaaga 533701 aaaatctttt caaatgaaac tgactcaaag gaaaagatca catactttcc tagaatgtat 533761 taccaggtca aaaacaacca catctatatt cgtattgcta tggacatgag ccgttttcag 533821 aatcgcttcc tagacttagg aaaggatttg gaaaacggct tattttgtga cttggttgat 533881 aaacaaatgg aagaaggttt tgtatgcttt aagcttcttt acgatgtcaa aaagaatcgt 533941 atttccattg atgatgcagt agctgagaat ggagtccttc cgttaatgaa gcatatctca 534001 tggcaatttg ataagttgcc gcacatgctt attgctggtg gtacaggtgg agggaaaaca 534061 tacttcatgc taacgatcat taaggcatgt gttggactgg gggcagatgt aagaatacta 534121 gaccctaaaa atgcagattt agcagacttg gaagaagtac ttccgaaaaa ggtctattcc 534181 caaaagaacg gtattcttat gtgcctgaga aagtctgtag atggcatgat ggaacgaatg 534241 gatgaaatga agcaaatgtc taactataag acaggtgaaa actatgctta tttaggctta 534301 aaacctgttt ttatcttctt tgatgaatat gtggcattta tggatttgtt agatatgaaa 534361 gaaagaaacg aagccctttc ttacatgaaa cagttggtca tgttggggag acaggcgggg 534421 tattttctcg ttttaggcgc acaacgtcca gatgcaaaat atttagctga cggtattcgt 534481 gatcagttta gctttcgtgt ttcattgggt ttaatgtccg atacgggtta cggaatgatg 534541 tttggcgatg ttgaaaaagc atatgtgaat aaaaaggaga cagggcgagg atatgccaat 534601 gtgggcacag gttcagtgtt ggagttttac agccctatcg tgccgaaagg atatgatttt 534661 atgtcatcta ttaaaaatgc gctggttgga gtcgagggag cgcaggcgac ggcagtcgcc 534721 agcggcagcg taagcgacca gacggccagc ggcgaaggag tgagcgaagc gaatggatga 534781 gctaaaacaa cccccccacg ctaacagggg ggtagtaatc gtaaaagaaa aaaatgaagc 534841 cgttgaaagt cctttggtat caatggttga ctatattcga gtctctttta aaactcatga 534901 tgttgacaga attattgaag aggttcttca ccttagcaaa gactttatga ctgagaaaca 534961 atctggtttc tatggctacg ttggcacgta tgaactggac tatatcaaag tcttttattc 535021 tgcgccggat gacaacagag gtgttttgat agaaatgtcc ggtcaaggtt gccgtcaatt 535081 tgaatccttc ttggaatgcc ggaagaaaac atggtacgac ttctttcaag attgcatgca 535141 acaaggcggt tcgttcactc gctttgattt agctattgat gataaaaaga catacttttc 535201 tataccagaa ctgttaaaga aagcccaaaa gggcgaatgt atttcacgat ttagaaaatc 535261 tgatttcaat ggctcctttg atctatctga tggcattaca ggcgggacga caatatattt 535321 cggttctaaa aagtcagaag cgtacctttg cttttatgag aaaaactatg aacaagcaga 535381 aaagtataac attccgttag aagaactagg cgattggaat cgttatgaat tgcggcttaa 535441 aaatgaacgt gcacaagtgg cgatagatgc tttattgaaa acaaaggatt taaccttaat 535501 cgctatgcag atcattaata actatgtaag gttcgttgat gctgatgaaa acatcactag 535561 agagcattgg aaaacgagcc ttttttggtc tgattttata ggcgatgttg ggagacttcc 535621 tttgtacgtc aaaccacaaa aagacttcta tcagaaatca agaaactggc ttcgtaactc 535681 ttgtgctccc actatgaaaa tggtgcttga agctgatgaa catttaggga aaaccgatct 535741 gtcagatatg attgcagaag ctgaactggc tgacaaacat aaaaaaatgt tagatgtgta 535801 tatggctgat gttgctgaca tggtcgttta aaaccaagct gctaaacctt aataaacaca 535861 ggtgatgcga ttaaacgtat gtgtcaacgg taccggaacg aagtgaggat aaggagttga 535921 catattcagc gctacccaaa ccctcttggc attgaacaaa caaccgtttg ttcctgccta 535981 ccggcgaggg agtcccccga tgattcgggg gaataggggg atagattaac agcaatccaa 536041 cgagctaccg ttggtgggtt tgggtgaaac ccaagaacta acttggaggg ataagatgca 536101 taatgtcaat ctgttgaatc aggctggact ggaaaatgct ttggaatcag ttggctgttt 536161 agatattgta gaagatttaa tagaaaagat gcaggaatat gttttgtatc ataccgaaac 536221 tgccgaaaga tttgcgattg atatctttac agtagtaaac aactacacta aaaaggttca 536281 tgcgatattt aatgttcttg aaaatgaaga cggtgagaca aatgttaaaa atgtagaatt 536341 tgaagtaatg cattttacgg agtaaggaca attttcctta tgactttaaa gggggaacat 536401 caggtgttta atattaatct gttgaatcag gcccgacttg agagtgattt ggattccctt 536461 gggtgtttgg atattgctga ggaactgatt gaaaaaatga tggaagatgt tttttacagt 536521 gatgtagctc aaagaatcat tgttcaaaca cttgctgtta taaataacgc caatgcaaaa 536581 cttcaagcta cgtttaacat cttagaagat gaagatatgg agacagacga acgaagcgtg 536641 gagtttgaag gaattagcta ctacgaataa ggggtgaaaa tgtgcggtgt ctgctgtaga 536701 taaacgattc aaaagcttag gttttaatgt gggcattccc tctttagttt ttgtgagaag 536761 tttaagcaga gattgcatgt tggttgttga aggagaacga gtaaaaggat ttgctgagta 536821 tcgttacaca ttctataaaa caagatactt gccagacggt cgaatgacta gcttaaaagt 536881 ttatatggag aatcaaagca taaaaagggt gttacatcgt gtagcatcct ttttatcttt 536941 cttggaaaga acgaaacaaa ttgaacagaa ggagtgtgaa aaagttgctc aataaagaaa 537001 ttggctctga taagaaggaa gaatcctttt ttcggtctgc ttttcaaaaa ctgaaacgaa 537061 ttgaaagacc ggaaaaagac aaacaaaaag taccccgtga caggtcaaag ctgatagccg 537121 tcacactatg gtcttgtgta gggagcttgc tatttatctg tctgcttgct gtgcttctgt 537181 caattaatac tcgctcccaa cttaatgaca tgaaagacga aacgaataag ccaacaaatg 537241 acgataaaca aaaaatttcg gtgactgctg ccgaaaactt tctgtcaggg ttcatcaatg 537301 aatatatgaa tgtgaagaac gatcaagaat ctattgaaaa acgtatgcag agccttgaaa 537361 gctatatggt taaacaggaa gataaccatt ttgaagatga agaacgcttc aatgtggatg 537421 gtttaaaagg tgatcgagag ttaaagggtt acagcttata taacgtgaaa gaaggtgata 537481 aaaacagcct ttttcaatat aaggtcacat atgaaaatct ataccctgta gaaaaggaag 537541 ttgaaaaaga agttaaagac ggaaagaaga aaaagaaggt gaaagaaaag gttaaaacaa 537601 acgagaaata cgaaaaacaa atgttgctga atattccagt cacaaataaa ggtgattcct 537661 ttgcggtgtc tgctgtccct tattttacac agatttatga tctgaaaggc gatattgctt 537721 ttaagggtaa agaagaaact agagacgaat atgcaggcga gaaaaaagaa tctatcgaat 537781 catttcttca aaatttcttt gagaaatacg cttctgaaaa gaaagaagaa atggtttata 537841 tgatgaaaaa gccggaagca ttggaaggaa acttgttatt tggggaagtg cagtcagtga 537901 aaatcttcga gacgaaaaaa ggtttcgagg ttttttgtgc tgttcgattt aaggaaaaag 537961 aaaatgacat tccggtaaat gaaaaattca gtctagagat tacggaaaac agcggtcagt 538021 tttatgtaaa taaactcaaa catcaatagg aggtttaaat atggatttca tgaatttctt 538081 tattcttggc gcagaccttc caacacttgg aggggtaaaa ggttgggcat cagatgttgt 538141 tatccaattc attacgattg tggtcatgtt catagccgca aagaatctga tgaaattaaa 538201 aatgggcggc attatctttg tttgctgtat tggcagtgcg gtaacgtggg ttattaaaca 538261 ctggtcagaa ttctccggct ggatcaatgc gctaatggaa aaattgtaag ggggcatctg 538321 aatggggcgt ctggtgttca actaccggaa ggcaatgaga gagccgaaaa aaatccaaca 538381 attaaccgaa aattattcgt taccctttgc agttgagtta ataccggcta ttaactattt 538441 catttttgtt ggcttatgct ttggattctg gtacggcgtg aggatgattt tccctcacgc 538501 ttttgataac agttacgtca ttgtgatttt tgggatacca ttttttttaa cgatgcttgt 538561 aacgaaaata aagccggaag gcaaaaacat ctatatatat ttctttgatt tcgcaaagta 538621 ttacttcttc atcaagcttc cacaaaagaa gtattgcaat gatcgaaaga ttgatttaag 538681 taacgaaaaa caaattgagt ttcgaaaact tgtgaaggtg gtggattatt caaatgagac 538741 taaaaacgcc tatgaaggca atacacaaga atttgctgtt aacaagaacg ggcgacgtgt 538801 gggcgtacta ccgaataaaa agcaattcga ttcctatgca aaataaagaa aaagttgaat 538861 cgtataaaaa gaagtggcag catctttttg aagaaattac atcttatgag gattttcact 538921 tgatgatgta tccaagtgag tatgaattag aaaaacgatt taaggattta gaaacagata 538981 ttgcggcaga tgcaatggat gtggcacgtt actacaatga agaaaccgta aggctgttag 539041 aacagcgatt aggaaggctg acaaagtacg acttcatttt aggtgtaaaa ctgaaaagca 539101 gtcttgtaaa tattagtgtc gaacttaaag acaatatact atcttttttc aatacagcga 539161 ctgatacagt cgtgaaaatg ctcgggtggg aacaaaatgt ttccacctct ttttttgaaa 539221 aatatgagga agtcgaagaa acactagcga atatcatggc ttctgttcgc ggagaacggc 539281 tttcagaaac agaaatgaca tacattaacc gttatcactt tgtacgtggg ttaaagcacc 539341 aaacgaatga agaaagtgag ataaaggatg ttcgctctat tacaaacacg atcatagacc 539401 ccactgaccc atcagtattg catttgcata gtgatcaaga tgaaggctat tcagcttttg 539461 tcgtgattga cgaatttctt cacaatatgt cggaaagtga tttgttttat gaagcacagt 539521 ctcttccctt ccctgttgaa gttcagatga aaattcaaac ggaatcaaag tccattacca 539581 agcctgccct caacctcaaa agacagcaat tgaaagaaga acaaaaagaa caacaaagca 539641 caggcgatcg aagtgatgtt tccactgtca caagtgccac aatgataagg catttacaag 539701 atgaaataaa gaaagaagat gtgcatgtga tgaactggct gtcggtgata gtcgttcatg 539761 gaaagacaaa aaaagaatgt gtgggaaaag caacgattgt caaaaggcat ttaaaaggcg 539821 ctggcattac ttgtcggctt ccggtggctg atcaattgaa ccttttttat aaaatgcttc 539881 ctggtgaaaa gttagacata accgataaga actggattca aaaaacaacg caagacggtg 539941 tggctgaaag tctgtttgct gttaactctg atattggttc gaaaatcggg ttctttctcg 540001 gttgggttga tcgtttccaa gagcacaccg acttagaaag tgccattatg tccagccgtg 540061 attttgtctt attccaccct ttcttagcga atcagcagtt aaaaggttca aagacacgtt 540121 ctcctcactg cttaatcaca ggagacacag gaaacggcaa gtcatatcta gcgaaattga 540181 tctttaacta tatcagcatg ttaaacatca aatctctgta tatagaccct aaaaaggaaa 540241 tgagaaagtg gattcaaaga gtcttgaatg atgagtacat tagagagaac tttcccttat 540301 atattgcaca tttagagaaa tacaactata tcacgctaga tcatgaaaac acgcacaact 540361 ggggagcgct tgaccctatc tccttcctcc ctcctatgaa agcaaaagag ctagttcaag 540421 tcatttttga acaagtatat gactttaaag ggaaggacga cataaacaca gctttccttc 540481 gtgctacgtc agaagtgatt gatgcgaaac aaaaaggtga acaggtcggc tcacttgata 540541 ttattcggaa gatgcagagc catcccgaag aagctgtaca aaaagctggt gactatttaa 540601 atgaggtcgt gtcagattcc attttgaaac tttgtattca tgatggttca aatcctgcat 540661 tgtcactaga aaagcgaatt accattttag aagttgaaaa tatggatttg ccggatcatg 540721 ctgagcgact tgaaaactac acgatatcac aactaaagtc tagtgcggtc atgtttgcac 540781 taggtaagtt ctgcgagcta ttcggcatga atcaagacga acagactgtt gaatttatag 540841 atgaagcttg gatattcacc acgtcacaac aaggaaaaaa agtagaaaga caaatgcgcc 540901 ggattggtcg ctcatacaac aatgcggaat acttcatttc tcaatccaca aaagacgctt 540961 taaaagaaga ggattctgga aactttggcg ttgcctttgc ttttgacgaa ccaaacgagc 541021 gtgaagaagt gttgaaatgg atgaacatgg aggtcacaaa agataacaaa aaaatgatgg 541081 aatccatgtt tcaaggtcaa tgcttattta aagattacta tggccgcacc tctaaaattt 541141 cgattgaatg cctattcgaa gaatggcaag gtgctctgaa aacagttgag aaaaaagccg 541201 tcgcatatgc ggaagaaaaa tatttgtaaa aaggggttga atcgtacatg gaaatagctt 541261 tcttaaactc tcttgttgtc acgagtccag gcttttataa agctgagaaa atcacattgg 541321 acgaagttaa acaatggctg aagcattatg atggtcgata caaaagtttt atcggacata 541381 aatcaacggc acagtttctg caaaaattat taggtatcag aattgagcaa aatcgaaaga 541441 ctttcagaca tatgaaatat caaaaagcaa tctgtttctc tctgtatgaa cgatatcctg 541501 aaaacgtgtt gctaacgcaa agagacttag agaaagccag ataccaattt tatttattaa 541561 ctcggttaga ttaggaggtg gttgtaatga aaaagaaaag aattttgatt gtgtcggcta 541621 ttgtgttgct gtttttaact gttgcttcag ctgtaacggt attttcggct gatggagata 541681 caacgacgca gccaaaagtc gaaaaagctg gcggcgtgga attgaaggtg aaaaggtttc 541741 caatctcacg ctatcaagcg aataatgaag catctgacga tttaatcaag ggggcgtttg 541801 ttgggctgac aaacgtcact ttttcttttg cgggaaacat tgtccgtgtg gttgatacgg 541861 ggatggatat tttgtataac ttgcaaccga ttgacgagtt cgcaaattct attacaaacg 541921 tctctaaaac agtttataaa acactgaaaa agaatttcgg tgaagcttta tttattttca 541981 cgtgcgccta tgttgtctac ctattctgtg tgagaggtag cgtaaaagaa gcaatgcggc 542041 ggagtattct atttatttgt gtcatggtga tcggtgggct ttggatgtcg aacgctggtt 542101 attacatgaa agtattgaat gccttgtctg tagaagctca aggaaagctt ttaactgcgg 542161 ggaatggatt ggttggcatt gttcaagatg aaggcaattt tgcagacagt tcagcgattg 542221 aaaaaggaaa agaaatggaa ggcacagttg cggttatgcg taatctttac tttgacattg 542281 ctttgatgaa gcctttttta attgtgaatt ttgatgaaac aagcgaaaag aaaatcaatg 542341 aggaagatac agataaaggc ggacttaatc gtatagataa actgctttct tataagcttt 542401 cagaggatgg agaaaaagat aaaaaagatt atataaaaga gactgaaatt gatgattata 542461 aaaatgaatc tatgacttct ggaaatgtgt ttaatcagct gggagagtct tttatcgctg 542521 tggtcgcttc tattgtcatt gggataccat ttttagcatt agcgttcttt aatttcttgc 542581 ttcaagttgt cgctttagtg atagttttct ttgtgccatt tgctttcatc ttagcgtatg 542641 ttcctcaatt agcttattcg ggatttgtta cgcttggacg cttggggagt gtttacctac 542701 tgaaagcaat gttaggggtt atcgttctgt ttgtgtacgt gacttgtttt attgttgaca 542761 agttaatacc gccaaatggt tttggaatgt atcttttaaa tgttgctgtc cttgcttcaa 542821 tcttgtggat tggttttcac aagagggatg ccattatcaa gtttgtgact gctggaaaag 542881 ttgtttcagt tgataataat atgatggaaa acatgagaca aaacattgtt cagcctgctt 542941 gggaacaagc gaagaaaata ggtggagtat ggggtaacgg aggcggcgta tttactgact 543001 ttacaaagca ttttggggga agaaaagacg gttcgaatgc tgatggcgta actggtgctc 543061 caagtggtgg cggtaattca ccgagtggga ctgctatggg atatgataat actcatgcta 543121 tttcaagaac cccgcaaaaa gaaacagcta acggaatagc taatcataac agtcgaagct 543181 taaaacgcaa tcctcaaact ctatcgaaag aacaagaaaa gcaaaaacaa aaagaagcct 543241 ttgcaaatgc aaaagaaaat aaacagcaat cccatttagc cagattgaga aaagacggaa 543301 taaactctcc tatgttgaaa gatgctttga atgaagggaa tgaggattta tccaaacgag 543361 cacctatctt gcaggataaa aaagatgaat cagcacgaac agatcaaaaa gaatatgtgg 543421 aacagcttct taaacagccc aataaccagc aacaaactga cgatgcatca ttacagcatg 543481 aagaagaatc tacttctaat cgtgcgcctg tcttacaaga gaatgaaaaa gatacagaac 543541 gtactgatca gaaagcgtat atttatgacg aacaaaatca gaatcttgaa acagatcagc 543601 aacaagattt tgaagtccag aaagatgatt ctgtttccaa tagtgagcct gtagcacaag 543661 agaaaacagc agaaatcaaa cgatcagatc aaaaagtcat gatgaatcaa cctgaaccgc 543721 agctcggttt tgaaagtcct caatctacaa aagtagaaaa tcaacctatt gccaataacg 543781 aacgtaaaat cagaccatct gaacccgcaa aagttcattc agatggtatt cgtgttgatg 543841 aaaaacaggc tgttgctcct gctgaaaata agactgtatc aagagaaaaa cagccttcat 543901 cacaaacaat taaacggact gaacaaagcg ttaattcatt tgaccaagtg tctttgaatg 543961 aaattgcaag acgctcttca tcaaaagtag aagatcgact gagaagggat gaaagaacaa 544021 gatgataagt aaaaaggtag ttcttccttt ggtattctcg gctcctttta tcttcttttt 544081 tgttttatgt atcgtagtgg ttatgacgat ttcaagagaa aatcaagtcg gggacgattt 544141 tataggcggc ggggatggcg aatatgaaac agttggaatt gcgccggaag tggaacgatt 544201 tagagcagta tttgagaaat atgcccgtca agaaggcgtt tttgaccaag tgaatattat 544261 tatggcgctc accatgcaag aaagtggtgg gcgttcttta gatatcatgc aaagttccga 544321 aagtatcggc ttacctccca actccataac tgacccagaa cgttcaattg aagtcggcat 544381 taaacatttt aagaaggttt ttaaacaggc tggcggtgat gttcgtttaa ccttacaggc 544441 atacaacttt ggttctggat ttatagacta tgtcaaaaag aatggcggga aatacacaaa 544501 gaaattagca cttgatttca gccgattgca agcttttaaa atgggctgga aaagctacgg 544561 tgacccaagt tatgttgacc atgtcatgag gtatgtgaaa ggctctgata aaaatgtgaa 544621 gcctgtgaaa ggctctatgg atttctatga aacggtcatg aaagaagctt tgaaatatga 544681 agggcaaccg tatgcctggg gaggttcaaa cccggaaact ggatttgatt gttctggcct 544741 tgttcagtgg tcttttgcga aagctggaat cactcttcct agaacagcac aagaacaaca 544801 tggggcaacc aagaaaataa gtgaaaaaga agcgactgcg ggtgacttag tgttctttgg 544861 cggcacatac gaaggaaaag ccattactca cgtcggcatc tatgtaggca atggcagaat 544921 gtttaattca aatgacagtg gaatccaata ttctgatctg aaatcaggtt actggagaga 544981 tcaccttgta tcttttggac gcattaaata actaggagtg aaaatatgaa aacacatatt 545041 gcatgggctt cagcttgttt attattagtc atgttaactg gatttttcac gattggacag 545101 caaacgtata agattgaaaa gttaaaagat aaaaatgaag ttttgagcga aaaaattaag 545161 gaattgaacc atatagaatc aacaagtagc gcttcggaaa ataaggcatt ttttgaagcg 545221 ttttttaatt actccgacat agatatacga tatgaaacag ttaagaagca cacaactgga 545281 aaagggtttg attatgcatt cccttctcgt tctgatcaaa agcacacagt cagcgtgcaa 545341 agtgaattac tatcactaga gagttattca aagccgttag atgagtctca tgaattgttt 545401 ttaaacattg ttgaagtcgc cacaactgca aattcagtca ctacgaatca agtgttaatt 545461 gtacaaacga ctatgaaaaa agaaaaggat ggttggttag tcgataatgt gcaggttaag 545521 ggaaatggat aaaaggtgga aaagatcaat ttgtttgttt atactaaata ttgaaaaagg 545581 aggtaatgtt tattttgaaa aaccttttta ttttccttag tttgatgatg atgtttgttt 545641 taactgcatg tggtggaagc aagtatgatg atgcgattga tgatgtaatt agccaatata 545701 aagagcataa aggaaatgac acagagataa atattaaaag agagaatgcg attgttagag 545761 tctatgaagg gggcaaatat attcagtttg cattttatat gccggataac tcttcacgtg 545821 aattaacaac atttaagtat tatgaaaaat ttggagataa atatgaaaag atgactgata 545881 tgccggggaa tggggaaaat gatcgtctgg ggttatcaaa gaaaacacca gactatgaag 545941 aagtaaaagg agaagagaca gagttagagg agtaaaccgt gtgtttactc ctcttttagt 546001 tttattgaca ttggtaaaac agagataggg taagaactta gctaattaag aatgaaaatt 546061 ataaggttta taagttggaa actaaatcaa atatgtcttc taagaataga tttatgggta 546121 aaagttgttt ttacactatt ggtgctacta gcagtggcat ttaagttatt ttaatttcgt 546181 attaaattta gcctttatcc tttcccattt tttatcttct aatgtgagat catacatacg 546241 gagtattttt tcttttaaat taaataagtc tattggttcc tccaaggaga atgctttttt 546301 atttttatca attactcctt ttatttcgcc cttaaaacca gggaggatga aagtagagca 546361 gttattgcta ttcacccaag tagcccccat ttcattaagg cagtatacgc tatcatagta 546421 attatcggat aacatataaa agacatatgc acccttaaaa agatgttttt ttagatattc 546481 gaaaatatct tcatctccag gaataccatg ataaggtgaa gaagtgtata ttatatcttc 546541 agaagacact cctatatcct ctagtaattc aacgaaagca ttacatacaa ttttgtcttt 546601 tgaggagtgg ctaataaata tttttttctc taattctcta ttttgatcac ttgaaaagtg 546661 agttatgctg cttttttcag tctcatctac tacaggcaat tcatctaaaa atttttttat 546721 tttattttct gtttcatgat gttcaaactc attaaaaaca aattcatttt tatatatttc 546781 attgcggttt cgtgcatacc aagtcttaag ttgttctagt gaataacgaa ttaactcaat 546841 atcatttgat tcaagagatg ttcgaaattg atcaataata tttgtgagta caggctcgcg 546901 agagtaatct agaagtactc ctataattcc attagcctca aattttaatt tttttaatgt 546961 gtccattaga tttcctccga cctaatttaa tccattgttt gtaaacattt catatctaat 547021 tatataacat agactcctat tctaactact tattttaaag cagtctggat tgtttgggta 547081 attcataaaa aaataaaaga aagaaggagg aatagagttt ttcttttttt tgtttgcaat 547141 gttactgtca agtcgcaaaa gaattgctat gaccgaaaaa aaaccgcaaa ggaatagata 547201 taaggtacct ttttgcaatt catctttgta aaataaaggt tattctgaca taatacaatt 547261 aatgtaaaaa ttcgcacaat tttatgtaag gatgggggaa ttttcttgcg gggtgttttc 547321 ttagataaag ataaaattcc gtacgactta gtcacgaaaa agttaaatga atggtataca 547381 tcaataaaaa atgatcaagt tgagcaagcc gagattataa aaacagaagt agagaaagaa 547441 ttgttaaaca tggaagaaaa tcaagatgcc ctgttatatt atcaactatt agaatttaga 547501 catgagataa tgctgagtta tatgaaatct aaggaaatag aagatctcaa taatgcttat 547561 gagactataa aagaaattga gaagcaaggg caattaactg gcatgttgga atactatttt 547621 tactttttta agggtatgta cgagtttagg cgtaaagaat taatttcagc gataagtgct 547681 tatcgaatag ctgaatcaaa gttgtcagaa gttgaggatg aaatagagaa agcagagttt 547741 tttttcaaag tgtcctatgt atattattat atgaaacaaa catacttctc catgaattat 547801 gcaaatcgtg cactcaaaat atttagagag tatgaagaat atgctgtcca gactgtgcgt 547861 tgtcaattta ttgtagcagg aaacttgatc gattcattgg aatatgaaag agccttggaa 547921 caatttttga agtctttgga aatttccaag gaaagtaaca tagagcattt aattgcaatg 547981 tcacatatga atattgggat ttgttatgat gaattgaaag aatataagaa ggcttcacaa 548041 catttaattt tagcgttaga aatttttgaa aaatcaaaac atagtttctt aacaaagact 548101 ttattcactc taacctatgt agaagcaaaa caacaaaatt ataatgttgc tttgatatac 548161 tttaggaaag ggcgatttat tgccgataaa agtgatgata aggaatactc agcgaaattc 548221 aaaatattag agggattatt tttttctgat ggtgagactc aattaataaa gaatgcattt 548281 tcatatctgg cttcgagaaa aatgtttgct gatgttgaaa atttttcgat tgaagtcgct 548341 gattattttc atgaacaagg aaatttaatg ctctctaatg aatattatcg tatgagtatt 548401 gaagcaagac gaaaaattaa aaaaggggag attattgatg aaaatcagcc ggattctatt 548461 ggcagcagtg attttaagta gtgtattttc aataacttat ttgcaaagtg atcataatac 548521 tgaaattaaa gttgctgcag atcgggtagg ggcatagctt agataattgg aaaagaggaa 548581 aaaagcttaa tcttttttcg aaggttaagc tttttctttt atttataaaa agtgaactaa 548641 ctatcagaaa gaaattatat taaattttat ttttttgttt aaaaagtaga ttatataaag 548701 gcaagctagg tgggggaaaa tatgtttaaa aaagaaaaag tcacagaata catttggact 548761 atactaatac caacaatcat cacttttatc attagttggg ttgggtctta ttacaatggt 548821 acttcgacag ttagtattgg acaacctaca aaagtttccg gtcagtatat cacgccaata 548881 aatataagtc cctatcatga tattaaggaa ttaagaataa cttttccgca aaaactagat 548941 gtaaaacaaa ttagttcaaa tgagcctata aatgtaaaat cagataagaa caatatagga 549001 gttgaaagta attccacttt tgagattgcg aaaatcgttg aaaataatag cgttcagttg 549061 ctaattacaa cacaaaaaaa gttaaacgat aaggaaatta gaattgataa aaatggaaat 549121 aacatttctg taaattatga atctcagatt gttaatcctg caaaaaaaca attaatcaat 549181 cttataatta cgtcatctat ttattttata atgcttaata tactagcatt gattatgaac 549241 aaaagatggg ataagtatta tgcaaaaatg aaaaatgaaa tcaaagaatt tgaggataat 549301 gcaaaagatc ttgataaaaa atcaaagaag aaaagcgagg aattatcgga gctgcgaaag 549361 accttgaacc aagcgtttga ggaaactgat aggataaaat atcatgagaa gaaaaaacaa 549421 atcctcctct tagctaagtt aaacgattat aaaaaagaac taaccttttg gagaaataca 549481 ataagaaaag ttctttatga acttcctgat ggagataaaa aagcagataa actaataggg 549541 acagttacat catctttaaa aacgtacggt acagtcgaaa aaaacgagca tgattatgaa 549601 agtttaaaag tagcagctgc cttactaaat gattctgata agagatcgta atgtactgga 549661 ttttaataaa ctattagaaa gaagattagc tgcaaacatc agaacgacca aacaatggtg 549721 gtatgtttat agagtttagt tgttgaaaag ggcgaactat gagtttgctg cccatttact 549781 gcccagaata aataacaaat catgaaaatc agtgtaaata aaataactta atgctataaa 549841 taaaggcttt tgtaaataaa gatatgattt tactaggttg agggcctagt gggtgaataa 549901 cccgtggagg ttcaagtcct ctcggccgca tctcaataat accaagggtt taaccacctt 549961 tggtattatt tttttgtgtg gaaaatacgg ctatgggaga agacttgctc accaaaactc 550021 accagttact taaagtaagt catccaaacg gtcggcggtt ccttctgttt attaggaaaa 550081 agatatccgt tcattgtaaa agaaacgaac catgtcctat tcgttcaaaa aaactaaagg 550141 gtgatacata ttatacatga ttaatatgta tcaccctttt ctttcttgtt caacaatcgc 550201 gcttgaggag aacataagct aatacaactg actcgatttc taaagttgct ccattctttt 550261 tttaaacaac tcatccacaa cctgttttaa aatctcgtac gactgaattt ccttgctcaa 550321 ttcgtaaata ttagataaca caattaattc atctgcgtga tacatttgtt ggaaatcaat 550381 tagttcgcga cgaattgttt ctcgatcacc catgattgta taccccagtc gactgtggag 550441 aatttctaat tcaaactgtg ataacgattc taggaagttt tcagtgggtg gaataagctt 550501 acttaaatta tttgtataaa tatcaatata cacctgcaaa tgacttgcag aaataaaaga 550561 tgcctcgtct atagattctg ctgcaatcac attaatgcaa gcgatcacat aaggttcttg 550621 taaataagaa gacggttgga aattttctcg ataaatagag agcgcttctt ccatcgaatg 550681 gggtgaaaat tgagcgccaa atgcataggg taaaccaagc tttgcagcaa tttccgctga 550741 atccgttgag gatcctaaca caaaaacagg cacatgcgtt ccaatacccg gataagcgcg 550801 aacctcaccc tgtacactct tatccccgac aaaacgcaaa atatcattta cttctctttc 550861 aaagaaaaac actccattat ggttggaacg acgaatcaca tcggccgttt tttgatccgt 550921 tccgggtgcg cgtcctaatg ccaaatctac acgatttgga tataatgttt caagtgttcc 550981 aaattgctcc gctacgatta atggggaatg atttggcaac ataatacccc ctgaacctac 551041 gcgaatgtct tttgtatttg ctaatatatg ttgtacaatt gatacggttg ctgcacttgc 551101 ataagcgtcg tgattatgat gctctgcaaa ccaaatccgt ttatagccca tattatctac 551161 agctttagct aatgacactg cagaatcaat cccttgtttc attgtttctc cttgtcttaa 551221 tggagcaact gataaaacag atatatcaaa ttttttcata atttcacctc taaaataatg 551281 aacttataca agatcaatgg aaaaaacatt ttgaaaaatt gtttcatatt aaatggtgtc 551341 cattcctctt tgatttgcat gcaaataaat atatactttc tcaaacgatc aatacatagg 551401 caaaataaag ttatttcaca atttcacttt acttttaaag ttttaagcaa acataaaaaa 551461 atgttcagtg aacaaaatat gtaaaataca tcttattttt cagaaaggat acaagaaaat 551521 gattgatgaa atagataaaa aaatacttga tgagctgtct aaaaatagtc gccttacaat 551581 gaaaaaatta ggggaaaaag tacatctcac tgcaccagca accgcatcaa gagtagtaaa 551641 gttaatagac aatggcataa taaaaggatg tagtatcgaa gtgaatcaag tgaaattagg 551701 cttctctata catgcttttc ttaatattta tatcgaaaaa atccatcatc aaccctattt 551761 agcttttata gaaacacaag ataactatgt aataaacaat tataaagtta gtggagacgg 551821 ttgctatttg cttgaatgta aatttccttc aaacgaggta ttagatcaat ttttaaatga 551881 cttaaataaa catgcaaact ataaagtgtc gattgttatt ggtaaatagt taactttata 551941 aaacggagat gtgcggtcat ataacatgat atatatgctc taaaaaagcc ctaggttgga 552001 tatggaattt accaagctgg ggccttttta tacattataa taacaagcgc attattcatc 552061 agacattaat gaagtattat aatgcttttt tacttcctta atagacaaat aaagctgata 552121 gtttccatac ttcaataaat cattcagaag gtgatttaaa acttcttgtg aatgaaccgt 552181 taccttcaga agataacatg catctcccga aacacgatga gcttcgctaa tttcattacg 552241 agtagcaata aatttcaata aatcatcatg catatatgca ttcatgaaaa agaagacaaa 552301 ggctgtaaaa gaaaacccca tcttcaattc atcaaccaca atcgaatatg ctttaatgat 552361 accgttatcc tccatttttt tgatgcgatt gcctaccgct tgtcctgtca tatgaatttt 552421 ttcaccgatt tctttccatt gtatccgagc atttttattt aataattgga gaatttgaaa 552481 atcaattgaa tcaatttgca tagtaactcc tttcacagtg aaaaagtttt acaaaatagt 552541 atttcatgag accatcgaaa attcaatgga aattatatat ccttatacag tataaaaatt 552601 ttaagaggtg aaaaaatgac aacagcttta ttagtgattg atattcaaaa tgattacttt 552661 ccaaatggga agatggcttt aacaaaccca gagaaagcag cacaaaatgc ggctaaacta 552721 ctttcacact ttagaaacac aggcgcacct gtctttcatg tacagcatat cacagaaggt 552781 aacatcgctc attttttcca tccaaataca gaaggtgtcg aaattcatga gtcagtacgt 552841 ccattagaga aagagacagt cattgtaaaa catatgccga atagcttttt caatacagat 552901 ttaaatggaa agctacaaga agaaggggtt aaagaattag ttgtttgcgg tatgatgtcc 552961 catatgtgta ttgatgcaac agttcgttct gcagttgaac atggttatgt atgccaagtg 553021 gtagaagatg cttgcgcaac aacaacattg caaattgaag ataaaatcgt tcctgctgag 553081 catgtccatt acgcatttat ggccgcatta aatggtgtct atgcaacagt aaaaaccaca 553141 gaggcatttt taaaataaaa gaatttcctg cgcgaacata acgtctttct tttcacaaga 553201 aagatgattc aacaacttaa aaaaggatgt tcagaaaaat acttctggac atcctttatt 553261 cattatcttt tattgttttt cagtatcatt attcccatct gataaaagat caagatgtcc 553321 tgtttttgat ccatagtaag accatataca gggattgttt ttgccataaa tatagatatt 553381 gatgaaggtt tacataaagc acctaattgc ttgatttact ttaatgttag atccctcaat 553441 aactccattc tcttctaatt tctctactct agctgtagct gctgggcatg ttaaatgtac 553501 tctctcccag atctttcatt gaattcggct attatacata atttctctat aattttttat 553561 ctgtttgatc tatttgaacg ttaattcctt tcgaaaataa agtcaaagag ttaaaacact 553621 tttttttatc tatgtattcg aacactgctg atattataca cttaactctg tcgatctaag 553681 acaaataaaa aaagaaagtg agttgtaaat atgaatatta cacaaattcg aaatgcaaca 553741 attgttgtaa aatacgcaaa taaaaaattt ttgatagatc ctatgttagc agagaaaggt 553801 acgtacgcta ctttccctga aacgatcaga caagatttat ttaatccttt ggtgagtttg 553861 ccaacatcaa ttgataacat tctggatggc gtagatgcgg taattgttac tcatctacac 553921 ctagatcact ttgatgatgt ggcaaaaaac gtattgccaa aaaacatcaa aatgtttgtt 553981 caaaatgaag cagatgcaaa agaagtaaaa gcaagtggtt tcaaaaatgt agaagtgcta 554041 catcaagaca ctgtttttga agggatccaa ttagtaaaaa caaaaggtga acatggcaga 554101 ggggaagagt tattaaactt aatgggtgat gtttgtggat tagtattcaa gcacccaagt 554161 gaaaaagttt tatatgtagc tggggataca gtttggtatg atgctatcga agacgagatt 554221 catacacatc aaccagaaat cattgtggtt aatggtggag acaatcaaag attagattta 554281 ggttcactca tcatgggaaa agaagacatc tatgaagttc acaaggctgc tcctcatgct 554341 aagattatat ctgttcatat ggaagctgtt aaccattgga cactatctag agaagaatta 554401 aaaaacttta gtaaagaaaa aggattctca agtaatattt tagtgccaga agatggcgag 554461 tcttacacat tttaatatga acaccgacaa ataaatagaa gaagctcata attataaaaa 554521 ctaatcatga gcttcttcta ataatgaata ttttaaattt taaatatatc gaaaatccta 554581 aatatacgga ataacaaaaa tggaatgttc caatgatgac aaaaaaactt gaaaagcaac 554641 aaagatgtgt cgttaggagg tagaattcat ggtaatgaca aaaaaagata caaatatatc 554701 aacacagcag cctctttggt tacaaggtta tattgattca ccagaaaaac aaaaccaact 554761 ttataaaaaa acattaaaaa tcttgatttt ttcacaaata tttgggggag caggacttgg 554821 agctgggata acagttgggg cgcttcttgc acaagatatg ataggatcgg aaaatgtagc 554881 aggaattcca actgccctct ttacttttgg atctgccgta gctgccctgc ttataggagc 554941 atcctcacaa cgttttggtc gcagagctgg acttgcaggt ggtttcctta taggcggatt 555001 aggtgctata ggtgtgataa tcgcggcttt aattaacagc gttgccctat tatttgtttc 555061 tcttcttatt tatggagcag gtatggcttc taatcttcaa gttcggtatg ctgggacaga 555121 ccttgcaaat gagaaacaac gggcaactgc tgcaagtatg gccttagttt ctactacttt 555181 aggagctgta gtaggtccta acttagttaa tacaatgggg gaatttgcag attcaattgg 555241 tgttcccaat ttagctggtc cgtttattat gtcaggagca gcttttataa ttgctggaat 555301 tattctctta atttttcttc gtccagatcc gctgtttgta tcaacagcta ttgcgaatgc 555361 tgagaaaaaa gacgataaag tacaaatagg aggaagtcta aaaaatcctg ctatagacaa 555421 aaaaggaata atggtaggag ctgtcattat gattttagct caactaatca tgacagctat 555481 tatgacaatg acaccggttc acatgggtca tcacggtcat ggtttaagcg aagtgggatt 555541 agttatagga ctccatattg cagcgatgta tcttccttca ccattgactg gtttattagt 555601 agataagttt ggtcgcacaa ctatggctat tgcttcaggt gccacacttc ttgccgctgg 555661 gttggtggca gctattgcac cggcagactc attatcattg ctaatcctag cactagtatt 555721 actaggggta ggttggaact ttggtttact aacgggaact gcccttatta tagattcaac 555781 acatccatct ctacgtgcaa aaacacaggg aacattcgat gttttattag cactatcagg 555841 agcagcaggt ggagccttgt caggaatggt tgttgcacat tctagttata caatactatc 555901 aatttctgga gccgttttat cattgttact cattccagta gttatttggt attttagaag 555961 gattcaggaa aaagcataag cttatataac tgtctttgaa gaacctaagt agacattact 556021 ttaccggaac ctcctttttc tatttattat agtaaggagt tgacatggca ttagtggcat 556081 gtgtataact acacaattat ttgggattca gagagcatgt aatgaacgga agagataatt 556141 atttatcact tttattattg tacggtgttc ttgtggcatt aagttcagtc aattttggtc 556201 taactgtttt ctttttgttt tcatcacctc tccatattat taacaaacac gaaaaggatt 556261 ttaatgaaaa taaaatgatt agcgtatgta tctctaattt tcaaaatgaa tgaatagtcc 556321 tttttaagat ttacacactt attctccaag gaaaaatgac tcaatttttc gattttttat 556381 gtaaatcaaa aaagaatcat gttagagtag gtgtgctgaa aataattcaa aaaattattt 556441 tgcgatatga ttaaagtaat attgccagag agtttcaatt ggacaaaatt gtaagtgttt 556501 aatacactgg ggctgcaatc aaatatgcac ctggaatcaa ttgctaaacg ggggagttta 556561 tatgaacaac aagaaaaata tctttgatat tgttatgtac attattttcg gtgtgttaag 556621 tctttttcta gttgcaaaaa ctgattatgg cactggagtt ttagtgtttg ttgcaatttt 556681 atacctcgct gttattgctt ataaaattaa gcaagtattt agtaattcag attcttaagg 556741 tgtaacacaa ggaggatttc aattgagaaa gaaaagagtt attacttgtg ttatggctgc 556801 atcattgact ttaggctcac ttttacctgc aggttacgct tctgcaaagg aggactctaa 556861 gacaacccct tcttacgaag aactagctct acattacaaa atgaaaagtg aaaagatttc 556921 atcgaacggg aaattagttg aaattgagta tgtgagtgga aatgaaactc acaaagttca 556981 gatgaacgga aataatcata ctgtaaaagt cgatggcata gaacaaaaag gtttaaactt 557041 tgagtatgat gaaaatgttg ctaaaagaac aaattatgaa aacaataatt tgaaatcaaa 557101 tgaattcaca acacaggctg caaaacctaa aaagggatac cattatgtgg ggactttatc 557161 tgggcataca aaagcagcta aaaatgcgtt atcagttaca atgtcattag tcggtattgt 557221 ccctggcttg ggatggggga gtaaggctgc cactatttta ttctcttatt gggcaaaaga 557281 acaaatccct gatgcgtatt ataaatatga tttatacgaa aaaggagcaa tgactgatag 557341 ttggtatcag tatgctacag ttcaattttt tgaagataaa gctcataaaa agaaaatggg 557401 caaaccttgg acaagtactc ctgcaaaagt agatttacct aatagctaat tttaaaatca 557461 ctttgtcttt ataaaggaca aagtgatttt ttgttataca gaagtaaaat ccctcgtctg 557521 aggaatcttg gaaaaaactt ggttcaattt tgatataaca tgtttttttc ttgctaattt 557581 agtttttcta tgtatcgcta cacattctaa ataataagat attagccgga cggttgatgc 557641 caagctcaaa agtttatatg gaagtcaaag cataaaaaag ggtgttacaa cgtgtagtct 557701 tctttttatt ttgccaacgt aacaagtgtg aaagtaatga tttgtaggat cagttaagaa 557761 aggtttaaga ttagatattg aaaaatttta tatattttca ataaaatact ggtactataa 557821 taaatgtata cagattgtat ggagatgtaa ttaattaaaa aggagttttt aattgcgttg 557881 gagtaaatgg ttcaatgttt tttgtatagt agcattggga tcaatatatg gttataaatt 557941 atttactaac caagaagtca gtactactcg tttaataata gcttctgtaa ttgtgttgtg 558001 gaatattgtt ggacttttta gcaaagaatc agtaaaacaa gcacagcaag caaattaaaa 558061 gtcataaagt tgggaaagaa ggatgttact tatgtagtat ccttctttat tattccttga 558121 aaaatgaaac aaattggaga ttacagctta tataatcaat tgaagtcgtt gattattttc 558181 atgaacagga gatttaatgc tttctgatga aatattatcg tatgaatgtt gcaagaggaa 558241 acgttactca aagattacag ggatgtgatg aacactcctc tttatcgcac tcacctgacc 558301 ccaaattgtt ggggaagggc aggtacggaa gatagagtat tttttcttcg taacaaatcg 558361 aaaaggttgg ataataaaaa acttataatc taaggcggta tatagttgtg aaaaaggcgt 558421 tatttcttat attagaccag tatgcagatt gggaaggtgt ttacttagca tctgcattaa 558481 atcaaagaga agattggtcg gttcacactg tttctttaga ccctattgta agctcaatag 558541 gtggttttaa aacatctgtc gattacataa tagggttaga acctgcaaat tttaatttgc 558601 tagttatgat tggcggggat tcctggagta atgacaataa aaaactatta cattttgtaa 558661 aaactgcatt tcaaaaaaac attccaatag cagcgatatg cggtgcagtg gattttttgg 558721 cgaagaatgg tttgctgaat aatcatagcc atacaggtaa ttttgtttac ttatggaaag 558781 attacaaaca atataaaccg attagcagtt ttgtagagaa acaagcagta agagataaaa 558841 atttggttac tgctaatgga actgccccta ttgaatttac taatttaatt ttagagatga 558901 ttgattttga tactcctgag aacatagaga aaatgatgta tatgaatcgt tatggttttt 558961 atcatttttg tgataaatat ggaaatccat ttgttgatta atttgctgga aatgattttc 559021 ccgaataggg ggctttgcga ttgagttgaa tttcctaata aagcaaagaa agatgatttg 559081 aggtcaagtt taacaaataa tgccatcaat attaatttgc agttatttcc gattcctgat 559141 ataataaaga agaattattt ttgttcggtg taaaggatag tatgaagatt gacttttcgt 559201 cttgatgata ctttgggcaa ggatagtata tactgtgtgg ttacacacta ggaggcaaca 559261 aaaatggaac aaggtacagt taaatggttt aatgcagaaa aaggttttgg ctttatcgaa 559321 cgcgaaaatg gagacgatgt attcgtacac ttttctgcaa tccaaagtga cggattcaaa 559381 tctttagacg aaggtcaaaa agtatcgttt gacgttgagc aaggtgctcg tggagctcaa 559441 gctgctaacg ttcaaaaagc ttaatcttca atcgtttata caaacaggct ctttatatag 559501 ggcctgtttt tttatgtcta tatcatactc aataaaaaac cctactcaac gttcgagtag 559561 ggagatgcta caaggtaata gaaaaagatt taaaacttca aaggtttgtt tacagtataa 559621 catactggat tgacaatatg cggaatgtat ataaattatt taatgttttg ttcaaatata 559681 gataactgac tctttttttc actaacctgt tcgttcattt aagtaagatt agatgaatta 559741 taaaaatggt ttcatctaaa tgttatcaac tcgcatatct cttttatgag aagaagataa 559801 acaattatta ttcaatgttg cagtggatat aagaaattct taaaaataat gaggagatcg 559861 attgtttttt tctcctggaa ataatcactt agagatacct aaaacaatga aagccctacc 559921 tctcttccat ccttacggct ccttgtccgt gccagtgtga atcaggatac taaaaaaagt 559981 gactatttta ttgagttttt tggtaaaact tcaatcttcg cagaagaaat gtaaataata 560041 aaaatggatt agaatgtagg aataacaaaa gaggtcgtta atgttctaaa cataagttgg 560101 agaagatttg cttttcatca taatattccg aaatatcttt tgggatgtat ctaaccaaaa 560161 ctttttattt gtttttcagt gattccttta attacttcca gttcactaat caaaaattca 560221 tatgcattat ccagcatttt tttttcgctt gcattaagtg ctttttcttt cttcatacgc 560281 attaaatcac gtacaacttc agcaccttct tgtatttcac ctgtttttat tttgtccgtg 560341 tttattttgt acctttgctt ccatggcagt aacctatcgg attctccatg ctgaaaaatg 560401 tgcataatgt gttttaatgc aagtatatcg gtaactggtc gtatattcga actcaatatt 560461 ttactcgttg gaatcataac tgtcatatta ctgattgaca ttcttatgac ataatactgt 560521 tgtttttcct ctaagaattc tttttcttct atggcttcaa ttatacctgc tccgtgcatt 560581 ggataaacaa tgttatcgcc aatttgaaac atatcatcca cctccatata tggtatcctt 560641 cttaagatta ccatatatgg aggtgtaata tcaaaatttt aataataaca tgatcgaatt 560701 tttgatgtca ataacttttt tgaaaaaaca gatcaagcaa aaacaatagg gaacgtgtcg 560761 gatttccaat caggaaaagg tcaattgatc cgtgtgagca gtttttcatt ggctcaatga 560821 cattacagaa atgatttgag tagataagaa agaacgatat tcgtgaaatg tcagctaaaa 560881 atatttaaag cacatgatta agttctaatt tctttaccga tttgatatgg ataacggccg 560941 acttacttaa tgatgcattt tcacttatct tgcaagcaga aaaaggtttg ttgataaaca 561001 tttagccacc aaattggcat tattatcagg gaaattgaca accttcaaat gggtattgag 561061 gcgagaagaa aaataaagaa aggagagatt ataaatgaag accagaacat aaagaagtaa 561121 aggggaaaga acaaggttaa ttgaaaagca aactatataa aatagtttgc ttttttttgt 561181 tatgacttca cttctttttc tttctcttta atgactaata aaacaccgct cagaattaaa 561241 aacgaaccta tccaaaatgt cccgcctatt tgttctccaa gcagaatcca tccgagtaag 561301 gttccaacca gaggctgaaa aaagaaaaag aggcctccac ttgaggcatt taataattgt 561361 aagccgtggt tccacaataa aaatgcacaa gctgttgaaa caattcccaa atacaaaagg 561421 ccacctagaa ttttagggtc aagcagtagt ggcgtaaaaa tcgtgctagg ggagtaccat 561481 taacagggac tccatttatt aatagaataa actttatgaa ttcatttttt tgtatgataa 561541 tggcgtcata ttcatcgctt gttgaaattt acttatgaaa taactggtac tgttaaatcc 561601 aacttgataa gacacttctg tcacattgga ttcagggtgt tgcagtaata ataagctttt 561661 ttgaattcta taatccatta cataacgtaa tggcgtctta ttcagcattc gtttaaaata 561721 acggcagcat tcagaacggc tcagttggcc agcttttgca atgtcctcta atgtgatttt 561781 ttcaacataa tggagatgga tccagtttaa catttgtttc attcgatgac tttttatcat 561841 ttcagattga tcgtactcta attgaaaacc attaacgacc aggtttttcc acattaacgt 561901 taattgcatc gtaatgtcaa tctcatagag cgatgtcttt tgttgaatca attgatttat 561961 ttttttaaca gcatctagaa tattttttgc ccactgttga tttccagcca aaaataaata 562021 gggcaaattg gttgaaaaca tatagggctg aacatagctt gaatacagtt cctgagataa 562081 aacgaaatgg ggtgacacat tcaagcaaat atacgtacaa tccgagcctt ccttttcttc 562141 ggccatgtgc aggtagccgc tattgataaa taatccatcc ccttcgtgaa cctctatttt 562201 ttcttcattt atttgaaaga gagctatccc ttttagtatc aaaacaaatt ggatttcatc 562261 atgccaatga agcggaatat agccatttat attttgattg atcgttgtct tgtagcaggc 562321 aactggcaat tctaccgttc ggtgctctgt taattctttt aaattttgat cgatcacaaa 562381 attcttcatt ctgacttcac acctcaatat atttatattt tttcattcaa tttgagtatt 562441 ttttatcatg ttttgcattt attataacac tattattata tttattagtg aggagtcatg 562501 tatgaatact tccaatagaa gaatgggatt gttctatgtt atcacagggg cgacatgttg 562561 ggggattgga ggcacagtag ccaaaaaact ttttcaagaa tatcaaattg atgtcaattg 562621 gcttgtaacg acacgcttgc ttacggctgg aatgttactt ttaatgctgc aactgttcag 562681 aaaggatcgt tcccaggtta ttgaggtgtg gaaacacaaa gcgtcggctg gccagcttct 562741 aatttttggc ctattgggaa tgctagctgt gcagtacaca tatatggcat ccattcaaca 562801 tgggaatgct gccgttgcta cgttattgca atatttatcc ccagtaatcg tcattatcta 562861 cacgctgttg cgaaaacaaa cggttcttac caaacaagat atcataactg ttgtacttgc 562921 tttagtgggt tgcttttttt tgttaacaaa tggttcaatg tctcaacttt cagtgccggc 562981 agctgcagta gtatggggag ttttatcagg attcgcggca gctttttata ctttgtatgc 563041 cgttggttta ttaaataaat ttgattctct tgtcgttgta ggttgggcta tgattattgg 563101 cggttttgca ttgggtttta tccatccgcc atggcaactg gattttcaac gattaactgc 563161 tgaggcgtat gcatatatct tattcgtgat attatttgga acaatgattg cgttctggtt 563221 cttcataaaa agcttggaaa gcctctctcc aaaagaaaca agcctactag gcagtctaga 563281 gcctctatca gctgttgtaa caactgtcgt ttggttaaaa gcgccatttg gttcttttca 563341 atggattggt gctatttgta ttatagggat aactttaata ttggctttac ataaagagcc 563401 ttctatggag agtgaaaaat cgatattaaa gattaggaat catgcaaatc gggatatata 563461 ggggcttttt ttgcttacat gaccggtccg gcaatgaaaa acactggtgg agtttgagcc 563521 ctctcggcag tatcaaaaat accaagggtt ttgacgccct aggtattttt tcttcaagaa 563581 ccttcaattt ttcttctctg attgaaaaac gtattacttt tttgtgattg gtatccaaat 563641 ttcactttta aaagatggtg atgttacatc cttatgctcg ttccacaata tttctggacc 563701 ttctatttgt tcgtaatttg acgatggaaa ccattcggaa taaatgcgtc cccatacttc 563761 ttgcagtgta tccggaaatg gcccgattga ttcgaataca gcccatgttg aggcaggaac 563821 ttcaagccgt gagaagttat ctggacaccg tttcgttgtg gctgcgccaa tatagtgatc 563881 gagctctccg ttttcctctg tccgaccttc agaaaaattc gtggatgcac taatgaggcc 563941 tgatggtgct acattagata gctcttttag tttatttatt gctttttcat ctaaactttc 564001 ccacatagat gcaatttccg gattaattcc tttgaaaata ataggaactc tttttttaat 564061 gccaacgatg cgaaatgcct ctttttcttc aatacggtag ttcatttcat ttcctccttt 564121 aattgttagc tggaaggtca ttcgtggata agctttaagg gaatggccat taaatctggc 564181 ttttgatggg tttatgccat gtaaattttg gaatgcccgt gcaaaagaat ctggtgagtt 564241 ataaccgtac tttattgcaa tatcaatcac ttttacattg ctgtctttca gttcaaaagc 564301 tgcaagagta agacgtctgc gacgaatata ttccgataat gaaatacctg caaggaagga 564361 aaacatcctt ttaaaatgat attcagagca gaaagcaagc tttgctgcct cttgaaaatc 564421 aatatcatta gtgaggtttt cttcaatata ctttaacgcc ctattcatac ttttaagcaa 564481 atccatttat ttggcctcct ttaaccaaag aataacagga gtgaaatgta tttatccgac 564541 attctgtgca cagttttgca ggatgactta tatgaaataa agtaagtgat tcacttgtat 564601 ttgtacaggt tttattgaag catgctgttc ataaaaaggc atcaataaaa gaaagttata 564661 attgtcttat aaacggcaca ttcatataat tgagtgaaaa aggatgcgta tcatgcctat 564721 caattctttt gaaaattatc cgatgagctg gaagccatcg attgataaag ctgaaaagcc 564781 tatttataaa gcacttgcag ggcaattgga acaggatatt ttaaacggag ttttattacc 564841 tggaacaaaa cttcctccac agcgagaatt ggccgattat ctagatttaa atgtgagtac 564901 gatttcaaaa gcatttaaag tgtgtgagtt aaaagggctg ctgagtgcga ctgtagggag 564961 cggcacattt gtatcgtatg atgcgttgtc gaatgcgtat ttacttgagg atactaagcc 565021 gacacattta attgaaatgg gagcaatact tccagatcac gcttcatatg agcccttgtt 565081 ataccaactg aaaaacatgg ttcatgagga ggattatgaa aaatggttta gctatggccg 565141 ggcaggtgaa agcctttggc aaaaagatgc agctgtaaag ctcatccaaa gaggcggatt 565201 tgaaacatcc gttgatcaca ttttatttgc aaatggaggg caaaatgcga ttgcagcgac 565261 attggcgagt ctttgtaagc ctggagatcg catcggagtt gaccatcata cgtaccctgg 565321 attaaaaact gttgcatcat tgcttagtgt gcaaatcgta ccgataaaat cagaaaacga 565381 tgaaatgagt ccggagtcac ttgaatatgc gtgtaaaaac gaaaatatta aaggtttgta 565441 tttaatcccg gattatcata atccgacgac ttcctttatg tctgttgaga atcgaagaat 565501 ggttgcagac attgtaaaga aatataatct gtttgttatt gaggatgcat cgtaccatct 565561 tctcaacaaa aatccgcttc cggcactcgc ctcattcgca ccgcaacagg ttattcatat 565621 tgcaagttta tcaaaatcgt tagcgccagg cctgcgtttg gcttatgtag cagtgccgag 565681 acaatataag gagccaatat caaaggcgct ttataattta aatataactg tttccccgct 565741 attagctgaa cttactgctc gcacgattgt atcaaatcaa tttgaagtct taattgagag 565801 tcatcgtgaa caaaccattc gcagaaatca actcgtaaac cgatatgttg cgggatatac 565861 atgtttaggt gttgaaacag gcatttttcg ttggttgttg ttaccgggta aaatgtctgg 565921 tgccgaattt gaagaattgg ctgctcgact tggcgtgcaa gtgtatgcgg ctgaacgctt 565981 tgtagtggga aatagttgtc ctgaaagggc tgtaagggtt tctgtctgtg caccaaaaac 566041 acttgaagag cttgaacaag gattaatgat cctgagacgt ttgctagacg atcttaccta 566101 atattgtttg ccatacaatt atgacattgt atggcttttt tgtgcgtgtt atgatgatcc 566161 acatctagag ggaggtttat acaaaattgg cttttagaaa ggaaggtcag atgatgttag 566221 acaaggacag cgtaaaagca atagatgttc aaactgcttc attacagagc tacatcagtt 566281 caccagaaaa acaaaaatcg ttatacaagc gtacactatt cgttgtgagt atctcacaaa 566341 tttttggcgg tgcggggctg gcggcaggag tgactgtcgg tgcgcttatt gcacagcaaa 566401 tgcttggcac tgatgcgttt gctggtttgc cttctgcttt atttacttta gggtcagcag 566461 gatctgcatt aattgttgga agactttctc aacgttatgg ccgtcgaaca ggtctttcag 566521 ctggctttat gattggcgga cttggagcaa taggcgttat tatggcagca atcataaata 566581 gtattttctt gttatttatt tcgttgctta tttacggtgc aggtacagcc actaatttac 566641 aggcccgtta tgcaggtaca gacttagcaa atcataagca gcgagcgact gctgttagta 566701 taaccatggt ttttactaca tttggcgcag tggcaggtcc aagcttagtg aatgtgatgg 566761 gggatttcgc tctttctatt ggtgttccat cacttgctgg ccctttcatt ttagccgcag 566821 cagcatatat gttagcaggt gtggtccttt tcattatgct tcgtccagat ccattagtta 566881 tagcaagaac aatagaagcg gcaaatgaag agcctggtga taaaggacat ttggcggcaa 566941 ctgagcatac agaaaacaaa aaagggataa tcgttggggc aacggttatg gttcttaccc 567001 aaatagtaat ggtagctatt atgacaatga caccggttca tatgagacat catgggcatg 567061 acttgggtgc agtcggtctt gttattggtt ttcatatagg tgctatgtat ctcccttcac 567121 ttgttacagg tgttcttgta gataggttgg gacgtaccgc aatggctatt tcctctggaa 567181 caacgttgct tttggcaggt gtaatagcag catttgctcc gggagaatct atgattcttc 567241 tcgtcattgc tctttcttta ctgggattag ggtggaattt tggtttgata agcgggactg 567301 cccttattgt agattcaact gatactgcca cacgagctaa aacgcagggg acagtggatg 567361 ttctgattgc gttgtcagga gctgctggcg gagcattatc tggaatgatt gtggcaggtt 567421 caagttacct cgcattatca cttattggag ggattttgtc cttattactc attccggtgg 567481 tggtatggtc taggggccgc taaagggtag gattgtttaa tttacattaa tttgttatat 567541 tgttagataa agtatattgc agcatctaat attctaacga actatagttg ctccattaaa 567601 tctattataa agatttgacc aggattcctt atagctgtgt cactcactgc atattcttta 567661 attgaatcac ataaaatggt tatcggattt gaaaaaggca ggattactcg ctttaggtaa 567721 aggagtcata acgttgttaa aaaggttttc tcttgttatt gttacactaa tgatgtctat 567781 cgttgttgtt ttagcggctg ctaaagagtc gcctggagat catgtcatct catttgatga 567841 acctattatc ttgatgatct caattggaat cgttgtattt ttattgatcc ctccattagt 567901 catgtccttt tttggcaatt tggttgtaag aataatatct ggtgtatacc aatgttttat 567961 cgttttcact tttctggggc tcattccaat tggatttctt attcccaatg gctttttgac 568021 aattctagtt tctattgcag gaactttagt cagtatagct agtgttgccg taaccttatg 568081 cattggcaag aataaaaaag atatataatc atcgaattgt tattttttca gattgtcagt 568141 gaaataatta tacaaaaaga gaaggcttgt gggccttctt tttttgttgt tgcatcatcc 568201 ccactttgag cttaatctat tgaataataa gagaaggaac ctatagaaga ataaaataaa 568261 taccgagatg tcaaaaataa aactggactt cattattgtg aattcacgta aatgtaaaaa 568321 gattggaaag aggggaattc cttcatgaca aatagcagaa caaatccgaa ggttgatgaa 568381 tttttaagta aagcgaaaaa gtggaaggaa gaatttgaga agttgagaac catcattctt 568441 gactgtgagc tgactgaaga ttttaagtgg atgcatcctt gttacacata tcataataaa 568501 aatattgttt taatacatgg gtttaaagaa tattgcgcgc ttctgttcca caaaggcgtc 568561 ttattacagg atacagatgg aattctcatt caacaaacgg agaatgtaca ggcggcgcgc 568621 cagattcggt ttacaaatgt tcaggaaata aatgagctag aaaacatttt gaaagcctat 568681 attcacgaag ccattgaagt tgaaaaagcc ggtttgaaag tggatgttaa caaaaatatt 568741 gaattgaaca ttcctgaaga acttcaaaat aaattcgatg aaatccctgc attgaaaatt 568801 gcttttgaag ctttgacccc gggacggcaa agagcgtaca ctctttattt ttctcaagcc 568861 aaacaatcca aaacccgaga atcgagagtc gaaaaatatg tgcaaaaaat tctcgatgga 568921 aagggattaa aggattaggc acgccaaggt tcaggctaaa ggaatagcat catagcgtaa 568981 taagatcatt tctatagaag aaaaacaagc atagtaagat gcttgttttt tcttaggaca 569041 acattcactt actgctgaaa tgcttctaac attgtatgcc actagacagc gttataaaat 569101 attaatgcaa cacctagaaa tctatccaat gaaatagctc aatggtatgg ctcattacat 569161 ttagaatgcc taggagaact aatagaaccg gaagattttt agcaagttac tacactccaa 569221 actttgtttt tgtattaata taccttatta accattgttt ttagtcaggt gcagacaaac 569281 gaatactgat taatgaatca tcatgatatc aatgagccgc ttgatttttt catcgtcgcc 569341 tgtatcaacg tacactgttt ttctgttttt tatgatactc tcagtcactt cccgcatgac 569401 gcctttttct atatcatcag cggaatccca gcgtaaaggc acattatata catgaattgt 569461 gccatcccca ttgccatgat aagtgactga tccatccact aaacgagaac ctgccaactg 569521 ggtcacattt tctggatagc tggcacttgt atcatcatta ggattaattg gctcgccagc 569581 cgcaatatgt cgaacattta attcatctat ctcttgatta ggtccaagtt gaagccaaac 569641 tctggcatat tcaatttttt ccgaagagta tgctgccaat acattgtctt ctttgctttt 569701 ctcttctgct gaagaggtat catttgcagc ttttgttgcg gattcttctg attctgttat 569761 tggctccgct tcatccttgc gtattttggt gctctcttca ggctcagtgt gtttttcgtc 569821 agtttgcaca gcagaagctt gatttgaagg ttgttgtgct tctccatcct tactgtccgt 569881 acatccagca agcaaaatca taagcagcag ggcagtattg caataacata tctttctgcg 569941 tttcttcatt ttttcattcc tctctattaa ttcaggtcag cttcatatat aagtttatgt 570001 atctaaatat taccatggaa tagataggat gatattgaaa actgtttaag aagaggaaac 570061 gatcttgaat agcatcgcga aaacctaaga atcttaagaa gttttgcccc tttttcttca 570121 ggtattgaat gtaaagtggg atataaatgc aaacaaaaac gaaatgcctt atccacctcg 570181 tgtcatggca gaaaaagtgg gggatttatt agagcggatt tgataatggc ggcaggtaaa 570241 tgggtgttga cttatatgtc taagcgggag actcaagtct gctcgatcgc atacaaaata 570301 ccaagggcca gcaacccttg gtatttttat accttcatgc atttttgaag tttatgctta 570361 aaggtctgcc ttactttgca aatcgccgag ctgctgcaac gcacatgata acggcgatat 570421 tcactgctac gagtgcccag cccactttct cgtgcagaat cactgaggca agcagcagtc 570481 caaaaaaagg ctggagaagc tggagctgcc caaccgctgc aattccccct tgggcaagac 570541 ctcgatacca gaacacgaag ccaatcagca tgctgaataa ggatacatat gcaagactga 570601 gcagtgcggg aacgccgatc gccgaccatg agtccggcgt aaaaaagaac gacaatggca 570661 gcataagagg aagcgacaga acgagtgccc atgagatcac ctgccaattc cccagacgcc 570721 gtgaaagttt ggccccttct gcataaccaa gaccgcatac gacaatagaa gccagcatgt 570781 acgcgtcgcc aagcggggat gaacctcccc cctgaatgag ggcgaaacct gctactaaca 570841 agctgccggc agctgagaaa atccagaaga cggggcgagg gcgttcaccc ccgcgcagta 570901 cgccgaagac tgccgttgcg agtggaagaa gtccaatgaa gacaatggcg tgtgcggatg 570961 tgacatgctg aagcgctaaa gctgtcagca acgggaaacc aatcactacg ccgaacgcta 571021 ccactaacaa tgaaatgaga tctcttttgg caggatgctg ctgccggaag atgagaagga 571081 gacctcccgc cagtacacca gctatcgcag cacggcaaac tgtgagaaat aacggatcga 571141 agtctgacac agccaaacgg gtcgcaggca gcgagccgct gaaaatgagt acgcctataa 571201 aaccatttat ccagccattt gttgttttgt tcattataat cactccacat atctttcttg 571261 ttcattgtct gtattttctt aacaaaacca gcagctaagg attacaatga ctataaactg 571321 gaattggcct tttataaaca gccagttttc ataaaaaaat gcataccagt taggagaaca 571381 acgcgcaaat ggatatcacg ccttttttga atagaactct ggatattccg ctttatcagc 571441 agctttatcg gtattttaaa gaaaatatgc atcggggccg tattcaaaaa ggaatgaagc 571501 ttccttcaaa aagactcctg gcgaatcagc tttccatcag ccaaacgact gtagaacgtg 571561 cctatgaaca gctcgctgct gaaggttata ttgtgagcaa gccaagaagc gggtggtttg 571621 ctgattatca tgattctgat tttgcttatg atagaatgcc aagcacaaca cccattcaac 571681 aagaagcaga agaaaataaa caatggattg attttcatta tgggaatgta gattcttctt 571741 acttcccttt ttccgcatgg cgaaaaagca tggtcaatag cttagaccaa tatggacacg 571801 agctttatcg gccgggacat gttttaggag agtttgagct gagaacactc attgcagagt 571861 acctgtatca atctcggggg gttcattgcg gccctgaaca agtgattata ggtgccggga 571921 accctattct gctgcaaatc ttgtgccaag tttttgagcc gaatatttct atagggtatg 571981 aggatcctgg ttatccaaga gcacgcaaga tttttgaagc caaccgcatg aatattgttc 572041 ctataccagt cgatgatgag ggaatctgta tacagaagat caaagaacag cagccaaacc 572101 ttgtatatgt cacaccttcc catcaattta cgctgggaac cataatgaca ataaacagaa 572161 gaattcagct gctcaaatgg gcggccgaaa atcaatcctt tatcatagag gatgattatg 572221 acggggaatt taggtacaca ggacagccgg ttccttctct gcaagggctt gatcagcata 572281 accgtgtcat ttatatgggc actttttcta agtctctttt gccctcgctg cgtatcagct 572341 atatgattct tccttcgcct cttttaaaaa agggtcatga aatcacgtcc ttatataagc 572401 agacagtgtc ctgccacagt cagctaaccc tagctgaatt tataaaaaat ggagagtggc 572461 aaaaacacat caacagaatg agaaaacttt accgcaaaaa aagagccatt gtattagagg 572521 cagtgcaaag ggaattagga gagcatgtca gaatccgcgg agaaaactct gggcttcgta 572581 tcttacttga cgtttatttg ccatttggtg aaaaagagtt aattgagaag gcgaaaaaac 572641 atggagtaaa aatttatcct gtttctcttt cttatcaaca tcatcctcct acaaaaacgg 572701 tctcgctcgg gtttgcaggg gtttctgaat ccgacataag agaaggcata aaaaaactga 572761 aggctgcctg gaagatatga gggagctttc agtttagcaa aacggccaag tgacgactaa 572821 gtgttgagag ctgttcaata ttttttaagt atatgatgag tgcctgcagt ccaggccacg 572881 atacgtctgt ttagcgaaaa acagaatttt ttatttgctc ctcacagtgc taaaataaac 572941 aaaatagaca attgaaaaaa tagaggtgta agaatgaagt tagatgagtt tacaattggc 573001 caggtcttca aaacgaaatc attaaaagta tcaaaagatg atattatgcg gtttgcgggt 573061 gaatttgacc ctcagtatat gcatgtagat gaagaaaaag cgagtaaagg cagatttaat 573121 ggaattatcg cttccggcat acaaacactg gccatatctt ttaaactttg gattgaagaa 573181 ggtttctatg gagacgatat tatagccgga acagagatga atcatatgac attcataaaa 573241 cccgtatatc cggatgatga attgtttaca attgttgagg ttcttgataa gcagccaaag 573301 agaaatgaat tgggaatact cacagtattg ctatctactt ataatcaaaa agaagtaaaa 573361 gtgtttgaag gtgagttatc tgtattgatc aaacgataac tcagaaagcc cgcttttcgc 573421 gggctcgatt gaagcagatg ggtgaaagat gttagcgggt ttcctttgaa aaataagagg 573481 ttaaaacatc ataaacaata ggcaaagaag taaatccctc atcttctaga aaatgacctc 573541 cgtgctgaac ttcatataac gcagcatcaa tttgttgtgc cagatccttg ctgaatgaaa 573601 aaggcacaat ttggtcgtcc ttagaagcaa tgacagcacg gtgcttcgcg gactcgatga 573661 ttttttgatg atcaaacgat ccctgtgtaa attcatctaa catctgtaaa gtgggcaatg 573721 atttggcaaa gccggaaaca agtatgattc cgccaagctg ttttcgtaat tgaagatgtt 573781 ccaaaaatct caaaatggcg gggcaaccta agctgtgcgc aaccaaatac gtattttcat 573841 gtaaagtgtg ctgatataaa gagagtgtat ccagccaatc ctcaagtctt ggctggagcg 573901 gattaggcat gtttaaaatg tctgcttgga ccccatctgc gagcagacgt tttttcagcc 573961 aagggaacca atgatttgtt gaggaggctc tgtagccatg aatgatatag acttgttttg 574021 tcattatttc ctcctaagaa atattttcat tcagtataaa attcctctca ttgggaaaca 574081 agtacgcact tttttgtaag tagctttaca tatgaggccc tccttgtgcc attccccact 574141 tacacatctc atctatgagg ggatacaaag atcgccctct gtcagataac gaatactcta 574201 ctttcagtgg ggtgtgagaa acctcagacc gatgaataag gccgtcagtt tgcaattcct 574261 taagctgtgc gcttaacatt ttatgggtga tgaagggcat agcccttttc agctcgccgt 574321 atctcatcgt tttttcacac cctaactcat agagaattct cattttccat ttgcccccta 574381 taagagataa ggtgtattca aatggggctt gtttactgcg gcacaggcta ttcattgtaa 574441 tcaaacctcc ttttttaagt atcatatcag aataaattag gattttcggt gttgaagttt 574501 gagggcgatt cacgatctga agtgaaaggg gccgcttgct caacaggcgg cacggtacat 574561 gaatgttcta agtcaaagag ggttacctta ctgttagtta ctttatttaa aaaaacgcat 574621 gtttttagct gaaaatatct attatggtat atttaaatat aaagaaatat ttgagaaatg 574681 aggaatggta tgaatacacc caaaaaacat aagaaattta aagcgaaaat gattctccaa 574741 atcatcatgg ttatcattgg aggaatcata gcggcatatg gactagaaac agtgctcatt 574801 ccaaacagtg tatctgatgg aggggtgacg ggtcttagca tcgttggttc acagctattc 574861 aacttgccgc tggggatttt gattgctgtg atcaacattc catttgtctg gttaggatat 574921 aagcaaattg ggaaaagctt tgcattatta tcaattatcg gaatcgtatc gcttgccgcg 574981 gggacaagct ttttccacca cacacccgct atcatagaag gagataccct gttaattacc 575041 gttgtcggcg ggattatcct tggattcgga atggggctgg cgctgcgtaa tggcggcgca 575101 ttagatggaa ttgacatgct tgctgtgctg ctatcccgaa aactgccatt cggaacgagc 575161 gatctcattc tattcttaaa cctatttgtg tttatttttg tttccacagt atttggctta 575221 caaggggcat tgctttcagt cattgcttac tacattgcat ccaaagtgat tcatgttgtg 575281 gaggaaggct taagcggctc taaaaccttt caaattatta caacccaacc tgaattaatg 575341 gtagagacaa tacgtgatca attaggccga agcgccacat ataaagaagc ttacgggggt 575401 ttttcccacg agaaatttaa agaaatcaca tgtgtcatca accgtttaga agaaaccaaa 575461 ctaaaggaaa ttattaatga tattgataaa actgcctttg ttaccgtgta tgatgtagct 575521 gaagtgaagg gcagcaattt tagaaatctt aatcatcact aaaaaataga atgacctttt 575581 taaccgtaac tgacatgccg cgggtaattt aatcaaaaac acttttttga ggcttgtggg 575641 tgaataaccg gtgaaggtct gaatcacaga aataccaagg gcgtcaaaac ccttggtatt 575701 ttttctggtt attagatttt atcttcagct ttacgtgctg cttcgagctt atcaatcctg 575761 tctttatatt tttctcccca gtccttcatg tgcaggataa caggttctaa tgttcttcca 575821 aactcagtta aagagtattc gacttttgga gggacctgtt tataaacctc gcggtgaatc 575881 acgccatccc gttccaattc tcttaattgt agcgtgagca tacgctgggt aatttttggg 575941 tatagttttc gaaactcatt aaacctcttt ttaccgtcaa tgagatgata aagaagaatg 576001 cctttccact tacctccgat gatatctaat gttgtctcca ccggacatcc ttcaaagtca 576061 tcagaagaat aatcaatgcc gagtttacga tttctcaagc tgttcactcc taatagtata 576121 ctttttgata ctatatacat tcaatgtgcg tactttttat attttaatat acatcatata 576181 atgatgtcac atctaaggaa tgaaaggaat ggatcatatg aaaacactcg tactcgttgt 576241 acatccgaat atagaatcct ctcgtatcaa taaaaagtgg aaagaagccg ttttaagtga 576301 accagatgta actgtccatg atctttatga aaaatatcgc gatcaaccaa ttgatgtgga 576361 atttgaacaa cagcagctcc tggcccatga ccgtatcgtt tttcagtttc cattatactg 576421 gtacagcagc ccaccgcttt taaaacagtg gtttgatgaa gtgtttacgt ttggctgggc 576481 tcatggtccc ggcggaaata aattgaaggg gaaagagtgg gtaactgcca tgtccatcgg 576541 ttcacctgaa cactcttatc aagccggcgg atataacttg ttttcgataa gcgagctgac 576601 aaaaccgttc caagcatctg cccatttagt aggcatgacc tatctgcctt cctttgccga 576661 atatcgcgcc aatacaatca gtgaccaaga aattgccgaa agtgcgaatc ggtatgtaaa 576721 gcatattaca aatatagaat taaacccgaa ggttcgcctg caaaggtatt tgaaacagct 576781 ggagagtgtc gatttaacat aaagattgat ttttgaaaat cctgtactca ccaagcagga 576841 ttttttcttg ttcagcagag ggattttaac atatagcaaa aaaagaagaa gccaccaaaa 576901 ataagctatt tgcttggtcc tgactgctta tttttggtga aatacttatt tctctgtgat 576961 gaaataaagc aaagcgatga ccggaaaagc gattccaatc cataatgctg tactccatcc 577021 gcctgaggca tatgcccatc ctccaattga tgaccctatc gcaccgccta gaaagaagat 577081 cgccatgaat aatccgttta atcgactgcg aatttcaggc gccaacgaaa aaatagcacg 577141 ttgactgagc acaaggtttg cagatacacc catatctaac agaatagcag cggccactag 577201 aactgttata ccgacggggg agctgctctg aatcatgagc ggcagtaata aagagacaac 577261 gacaacaccg agagcgattc cagtggcaag cctggttaag cctcgatcag ccaggcggcc 577321 gcctattggt gcagtgactg cacccgcaat gcccaccaat gcgtagagtg ctattgcctt 577381 ctgagaaaaa tgaaaatcag gaccggacaa taataaagga acagttgtcc agaacaagct 577441 gaaagctcca aatacaaacg catgatagat ggcacggcgg cgtaagactg gagtcgtgcg 577501 cagcagcttc cacattgaac cgagtaaggc agtatagttt gtatttgctg ttggttttct 577561 ggcaggaagc acttttgata atacgatggc caggataaca cttaccacgg cggacaaagc 577621 gaatattgca ttccaccccc agatatcagc gactagacta gatatcggac gggaaagcat 577681 aataccgagt aataagccgc tcatgacatt gccaacaacc cggccgcgtg cagcgtctga 577741 tgcaaggtat gatgcaaatg gaacaagcac ttgggctgcg attgatccca atccgacgaa 577801 aaacgcagct gctaaaaaca gtgttccatg cttcacaaat gctgttagtg tcaaagccgc 577861 tgcgcttaga aggagcgata caacaataag ttttttgttt tcgataatat ctcctaaagg 577921 gacaaggaat agtaagccgg caacgtatcc gatttgggtg agtgtgacaa tcaatccagc 577981 accgcttgga gaaagtccaa ttgccttact aattaatccg accaagggtt gtgcatagta 578041 aagattagca acaatgatac cgcatgcagt tgcgagaaga agggttaaac tgggtgaaat 578101 cctctgacct gcttgtttgt ttccattagc catatgaatg aactcctttt taagtggttt 578161 tttgagtgta atcatgactt ctcacaagtg attttataaa ctgaacgttc agtttcgtcg 578221 attaataaaa ataatatact aaacgttcag ttttgtaaat ggatttctgt tttctttttt 578281 tattcaattt aagtatactg aacgtatagt ttatattgcg ggaaggaatg atttatgtgc 578341 agagtaaacg agggcggccg cgtgatgaag gaacgcataa ggcgattctc tctgcagcct 578401 atgacctatt gctggaaaaa ggcttcgatg cggtgacagt cgataaaatt gccgagcgtg 578461 cgaaagtgag taaagcaacg atttataaat ggtggtctaa caaggctgcc gttatcatgg 578521 acagctttct ttcgaccgcg acggacaggc tgcctgtgcc tgatacaggg tcgtcagtac 578581 aagatatagt aacccacgcc acgaatttag ctaggttttt gacaagccgg gaaggaaccg 578641 ttattaagga attaataggt gcagggcagt tggatgaaaa attggcagaa gaatatcgca 578701 cgcgattttt ccagcctcgc cgcctccaag cgaaaggcct tctagaaaag ggaattcaga 578761 aaggtgaatt gagagagaat cttgatattg aagtaagcat agatctcatt tacggaccaa 578821 ttttctatcg tctgcttata acaggggatg aggtgaatga ttcctatgtg cgtgatttgg 578881 tgatgaatgc gtttaaggga gttcaagcta cctctgctac agagagtatg tagctgataa 578941 gaactgcaaa agctgcggat tatatgacaa attggttcca tcgtacagtg aaatataaga 579001 tttttgttgc tgagcggaat catcgaggga aaagttctct tatcggatgt cgaaaaagaa 579061 gtcattcaat cgtgaataca taacatcata ttattacatt ccttttcatc gattggaaca 579121 agggttctat acttcaatgg aataccgcaa agttggagta tttaaacaac aggggaaaat 579181 cgatggccat tatgtaggtg tcatggcaat ggaaaaaata cttgcaatgt aaacaggcct 579241 ctaaagagac ctgtttttta atatccagat gattgtctag tttcagcttg ggctctatga 579301 ccactcccat aactgaaata gtctaatatt tataccagaa gggattgttt atataaataa 579361 aagtttatat aatgacgggg gcgctaagga aacgcgggga gcgactcagg ttttcgtttc 579421 aaagttttga tccttaagat atacggagcg ctacatatgg aaacgtaaag gggaatgtat 579481 aatcatttgg cgtgtatata acgatttgct tatatattga tttgggaagg aggagctcat 579541 atgacgattg atgttgcggc gatgactcgt tgtttgaaaa cacttagtga tcaaactagg 579601 cttatcatga tgagattatt tcttgaacaa gaatattgtg tctgtcaatt ggttgatatg 579661 ttcgaaatga gccagcccgc cataagccag catttgcgga aattaaaaaa cgcaggtttt 579721 gtgaatgagg acagaagagg ccaatggcgt tattattcaa taaatggttc ctgtcctgag 579781 tttgatacat tgcaattgat cttacatcaa attgatcaag aggatgaatt gttaaaccat 579841 atcaaacaaa agaaaactca agcgtgttgc cagtaaggag gcattagatt gacatcaatg 579901 attttggcag tattcatctt tttattaact ctagtattgg tcatatggca gccgaaaaat 579961 ttatctatag ggtggtcagc ctgtggaggc gcagttttag ctctaatagc aggtgttgtc 580021 aattttcatg atgtgttaac tgtgacaggg attgtttgga atgcgacctt ggcttttgtg 580081 gccatcatac tgatatcgtt aattcttgat aatatcggtt tctttgaatg ggcagcgctt 580141 catatggcta aggctgcaaa aggatacggt gtgcggatgt tcgtttatgt atctctatta 580201 ggagctatcg tcgccgcgtt atttgcaaat gacggtgcag ctcttatatt gacaccaatc 580261 gtattagcga tggtcagagc attacatttt aatgaaaaat tagtttttcc ttttatcatt 580321 gccagcggat ttattgcgga taccacttcg cttccttttg tagtaagcaa tttggtcaac 580381 attgtttcag cggactattt tcatattacg tttattgatt atgcatccag aatggttgtc 580441 ccgtacctgt tttcgctgct ggcgagcatc attgtacttt accttttctt tagaaaaagc 580501 ataccaaaac gctatgatct gactgaggtt aaaaaacctg ttgaagcaat taaagatcaa 580561 aacatgttca gactgtcatg gtatatctta gggctgctgt taattggata ttttgcaagt 580621 gaattttttt ctatccctgt atcagtggta gcgggcagca ttgcaatcat tttcttaatc 580681 gctgcgcaaa agagtccggc cgtccataca aagaaagtgg tgaaagaggc gccatgggct 580741 atcgtattct tttcaattgg catgtacgtt gttgtgtatg gtgtccgaaa tgccggatta 580801 acggatgtcc tttcagatgt gattcaagcc gcagctgatc aaggattgtt tgctgggaca 580861 attggaatgg gctttattgc ggcgattctt tcttccatta tgaataactt gccgactgtt 580921 atgattgacg cattggccat tgccggtaca gatacacatg ggatgatgag agaagcgctt 580981 atttatgcaa atgtgatcgg ttcagattta gggcctaaaa taacaccgat tggttcctta 581041 gcgacattat tatggcttca tgttctttcg cacaaaggta tgaagatttc ctggggcacg 581101 tattttaaaa caggaattat cctcacgata cccactttat tgatcacact tgtcggcctg 581161 tatatttggc tgctgataat ccattcttgt ttctaaaagg acaaggtcac tatatcaagg 581221 aaaacaatgc actggtaact cttgccgcag ccaaatggct gaagggtggg ggagaaaata 581281 ccttggggct aagtggaatg tgtacagcgc aggaatcgaa gctcaaggat gacatcgagt 581341 gctgtcaaag caatgaaaga agcagggatt gatatttcaa atcaaacatc ggagaaattt 581401 gatgatccgg caaaagcaca cggaacagaa gaagtgtttc caaagggtcc gtgatgaaat 581461 tggtgaccgt ttaaaacagt ttgctgtaac tggggaataa agaatcgata tattcagcgt 581521 tttcttgggt tatataatac aatgtgttgt tcaacaggtg tctgcgagct gagtgcagac 581581 acctgttttt gtttttattt gtctgagatt cgtaacaggg aagttattta gctggtgaca 581641 gaggaaaatt gatttgtgaa cagaatcatg aaggagacgg tgttttaaag gagttgtctg 581701 ttttgcagga attaacaaaa aaaaaataca gtagcttaaa aacaatgttt gatgacaaat 581761 attgtcccac atttgtctat tcaatattag accaaaccat tccgggagct gtttatgcag 581821 atgatcaaac ctttcctaaa tcgtttttta taggaactga atcaggcatt tattttattg 581881 cgggagacca agggaatcgg gattttcatg atttcattgc aggatattat gaagaacaag 581941 tgaaatcatc aaaacgattt accttgtttt cttccagtga tacatgggat agcgtactga 582001 aacccatact gaaagatgac ttaaaccaaa tgagaagagc tgcattttct tatcaaccaa 582061 aatctttcaa aaagactttg caactgccaa aggggcttgt attgaaaaga attgacgaag 582121 acatcatttc acatagcaca gcgtttaaca gcgcgtatta tgaggagtat tggaattctg 582181 tctcacagtt tgcttcaaaa ggttttggat ttgccgtatt acatggcaat cacgtagtaa 582241 gtgagtgtac ctctatattt ttagggcata atcgagcgga aatggatatc tatacacttg 582301 aagaatatag aggactgggg ttagcttatt gcgtagcaaa taggtttata gcgttttgta 582361 tggaaaatgg gattgttcct agctgggatt gtgatatttg caacaattcg tccattgcat 582421 tagcagctaa actagggttt aagacggtaa cggaatacac tatttactac tctggctaac 582481 cttaatgaaa gaaccttaaa aggagatacc aaccgatgtt ggtatctttt ttgttttaga 582541 gtttttttac ccttttagca gaaaaatggg tgatgaaaat cttattcatt ttatttactt 582601 ttaggtaggt aaaacatacc ccgccaactg taaccactcc gcctagcaga gagagcagtg 582661 tgggtatctc gccgatccag agccaagata tgatcaaggc taaagccggt gtaacataaa 582721 gtgaaagggt tgcttctgaa gcaccgacga atgaagtgac atatgctagt gcgaagtaag 582781 gaataaccgt cggcaataat cctaagtaaa cgatagacaa agttgcgctt attgaagcgt 582841 tcatcatctc ttcgcctaag cctggcagaa acacaagcat aggtattgtt ccgccccaaa 582901 tggtgaatgt aacgaatgga ataaaaccat atttttttat atagcgggct tgaaaaacga 582961 aataaatact ctccgaaaat gctgccagca ggatgaccaa gataccgctc attgaatatg 583021 taaagtctcc cgccccaaat gcaatcaata atacacccaa taaactgatc atagagccaa 583081 gccatttcgt aaatccaaaa tgctctttat aaaacaggcg ggatagcatg gctgagaaga 583141 tcggtgccgt agtaacgagt aagcttgcaa ctccggcact aactgttttt tcaccgatgt 583201 tcagcaaaat gtgatagaat gcaaatccta aaaaccctaa aagaaaaatg gcaggaatgt 583261 ctttcaagtc gggtaggcgc atctgagtca aaacagcaaa aagcaataat gccatagagc 583321 cgattaacaa acgaaataaa gcaaggtgtt ctggcgtgta cccttcaagt cctgcgcgaa 583381 ttcccggaaa agcagatgcc cataaaccaa tcatgagact atgagatatc attatttgaa 583441 ctgttttctt tcgcattcct ctcactcctc tttacaaaaa ccaaccagtt atttaatgtg 583501 tttctatact aataaagatt tgatgatatg gcttcaacca gttcaataga ttttgaccca 583561 accaatttat tttaaggaga ccgattctat gagctttcca gaagaaaaaa agatgaaaaa 583621 gctccctaag tacagacaaa tcgttcattt tattaaagag aaaataggaa atggagagtg 583681 gccgattgga agcaagattc caagccagcg cacgcttgca aaagattttc aggtaaatcg 583741 gagcacagtg attacagcgt tagaggaatt gatggccgat gggctaatag aaggcacaat 583801 ggggaaaggc acagttgtta tcaacaacac atggacactg atggctaaga attctgctcc 583861 cgattgggat caatatgtca cctctggcat tcagatgcca agccgaaaaa tcgttcaaga 583921 gataaatcaa tcagaatcaa atacagacct tatacagctc agtaaaggtg aactttcagc 583981 tgagattttt cctttggctg ttatgaaaga gatgatgggg aaggtatctc aacacatgga 584041 ggcattcgga tatgaagaac caaaaggtta cttacctttg agggaggcat taagcaacta 584101 tttaaaaacc attggaatca acgtctcatc ttcttccatt ctgattgtct caggagcgtt 584161 gcaagccttg cagctgatat caatggggct gttacaaaga ggatcaaccg tttatcttga 584221 tcagccctcc tacctttatt cattacacgt atttcaatca gctggtatga agctgactgg 584281 acttcctatg gataatgaag gacttttgcc tgaaaatgtt catttaacaa gaggagagcg 584341 gggaagggct atcttatata caaatccatg ttttcacaat ccgactggta ttcttatgtc 584401 taaaaagcga cgggaagaaa tcctagcagt aagtgagaat acacagcttc ctattattga 584461 agatgacatt tatcgtgagt tatggatcga tgaaattccg ccatatccta ttaaaacaat 584521 tgataaaaat ggacacgtac tgtacatagg aagtttatcg aaaacattaa gcccaggttt 584581 gaggattgga tggatcgtcg gaccggaacc ggtgattgaa cgtttatctg acattaaaat 584641 gcaaacagat tacggatcca gttcgctatc ccagagagta gcggcagagt ggtttacttc 584701 cggccactac cagcagcatg tagaaaaggt taggcagcaa ttaaaggtga gaagagaatt 584761 ggccttgagt gctttagaaa ctcatttgaa agaagtggcg acatggaata tcccaaaagg 584821 agggtttttt gtctggataa aaatattgcc ttccatatca atgaaattac tttatactaa 584881 agccttatca aaagggattc tgatcaatct cggcagtatc tatgctcagg aaaaagggaa 584941 ttatattcgc ttatcatatg cttatgcatc tcttgaagac cttcaaaagg ggatttatga 585001 gttgggttta atgattaaag aattggcaag caggtaactt ttatatcctt aaatggatgt 585061 ttcactaaaa aagagatcaa gcctaatgat cgcttgatct gataataaca agggttacta 585121 gaatagacca aatcatggtt cggtcttaaa ataatcatgt ctctgaacga aaagtctttc 585181 cgacttctct tcctaaacca aagtagtgtc tgaaattata gataagcggg ctccatttgg 585241 aagggttgat atggttttcg tccagaatga tactttcctc ggcatgaaaa tgtagtgcct 585301 gcgtctctac aattgcgaat gacgattcat attctggaag ccgaatgtgt ttcacttcgg 585361 cttcgatttg gatagggcat tctttaattc gtgttggtga tactgttttt gattgtaaag 585421 gcgttaaccc tgctgcctcg tatttttctt ttttatatgt aaatccgatc tgcttcttta 585481 aaggcggtat actctttttt ccgctataag atgaaattct ttcaacgttt tcccataaat 585541 ccgggccagg caagtttatg acacactctt tgtgtctttc caaattgtcg atggcttttc 585601 ctcccagtcc tactccaagg attatataat gtccaagagc ccaagaagaa gacataggac 585661 taatattagt ggttccatcc tcattcaatg tggttagaag aaatgtcgag gtaccataat 585721 acatgatctt gggtttgatt tccttaaatc gacgagtgtc ttgttttttg atgtccaacg 585781 ttttttcctc cttgtcacgc ttacatttat attgtaaagg attaacattt caactatcat 585841 cgaaatatga atgtaaggag gaaaatcatg aatcctaata ttgcaaaaat ctcttcgttg 585901 ctatcagatc cctcgcgttc ttccattctt ctcagtctga tggatggaag gatacaccct 585961 gcgggagagc ttgcatatct cgctaacatt aaacctcaaa ctgcaagttt tcacctgaat 586021 aaattgcttg aagcaaagct gattagcgta gagaagcatg ggagacatcg gtattacaga 586081 ttggctgact cagatgctgc aaatgtgatc gaacaattgc ttcatattgc gcctaaagca 586141 aaagtcaaat ctttaaaaga gtcaaaagag aaaaaggact tgcatttcgc ccggacctgt 586201 tatgatcatt tggcaggtta tgtgggcgtg caaatggcac attcactagt tgagcagggg 586261 atgttaaaaa aagttgattt aaactttgag gtgacttcag agggtgcttt attcttttcg 586321 aagttaggca tcaatgaaga gcaacaacgg aataagagga gagcctttgc ccgctgctgt 586381 ttggattgga gtgaacggca gcatcatatt gcaggagcat taggaaacgc cctattggtg 586441 cgcatgttag aagaagaatg gatcgttcgt atgcctaaaa cgagagcgat taggattaca 586501 caaagcggga aaatcgcgtt tgaaaagcac ctaaacgtga agatttagga ttttgaagcg 586561 gaaacatcag atgatgaggc acgatatcta ggaggagtaa gatttgttct aatcttactc 586621 cttcttctta ttttgaagca gctcgattcc ccattgcaat agagatgcgg ttccaactgt 586681 ttatttgatt aatgatcaga acaaggtcaa catattgttc ctcatcataa tgttcccgca 586741 cccgatgata tagctcatca ggaacccttt tagatggaat gagcgtgatg tgttcagata 586801 gttcgagagc cgctttctct tcaggtgagt aaaaatcaca ttcattccaa gcatgtaaac 586861 agtaaattcg ctgttcagtt tctcccattt tgcgggcatc ggacgtatgc atatctatgc 586921 agaaggcaca gccgttcatt tgagagactc tgattttgat tagttctctc gtcgttcggt 586981 taattgagga ttgtttcgtg tatttctcca tatccatcat gattttcata ccttcaggtg 587041 caatctcata gtaggacact ctttgactca taaagcaaga ctcctttcca tagaatacct 587101 agattgtatc ccggtattga tcattttacc aatgtgcggt ttgaatgaca gctgtttcag 587161 cgtcttttgg aaagaagctt ctttgaataa aaataagggt agccagcaat gatgagtgga 587221 gctgctaatg caagcagtat ccatgagcct gattggctgt ctctagtgac tctaatgaat 587281 atataagtac cgatcagaaa atataataaa gcacctagaa accaatacat gttcattcct 587341 ctttttcctt gctttttggt tgcgcatttt tgtctgtcat atggcttaat cgatcagggt 587401 tctgattttt taataccttt tcggtccgga ttccttttct ctttaatgat aaaattgtga 587461 gatcaatcga tttcaatgat gatcattcct tcaatgaata gtaagttcct tatgatttta 587521 aaggtaaatt tgaaaagata aaacgtacat agaggcagaa cgttcatgta cgtttgggca 587581 atgatcactt gttggaaact ctaatgtttc cctgcacctg atattgttgt gttccttctc 587641 ttcctataaa atgattggat acatgtatgt ttgcacgttg aaatatgggt tcgattttca 587701 tgaatctcta ttcggtgaaa caggtaaagg aagtggataa ggtttgctta taaggaatcc 587761 ttttaaagat aaatattact cacatgatag gcgggcatta aacatgcttg cactcagagt 587821 gccgggcctg gcttttattc tcatgatcta tatagcctct atcgtgctgc aatttgtttc 587881 tgggggctgg tccattttat tgctttatgc gtttaccata ttaatcgcca tttttgcttt 587941 gcttcattgg cactcatatc gctgggttaa gaaaagagtg attctgtatt tcgcggtaca 588001 aggtttgatc acctttgcac ttgctaatct catgactggc ttctttatac ttgtgattat 588061 cggcctttat gcatttttaa ttggacaaat tataggaatg gcagacagaa gaaggacttt 588121 tctcattctt tatctattgc tgctgctggt cataaattcg gcgtatcacc ttcataaagg 588181 tgaagttttg cattttattg ttattgctgc gccgatcatg attgtcatca tcacttatgc 588241 cgcaacattt tttgcccaag tcgatgaaaa aataaaagct caattgactc ttgaaaggct 588301 ggagctggct catcagcagg tagaacagct gacgctgcag aacgaaagac agcggatggc 588361 ccgagactta cacgatacgc ttgctcaagg tcttgtcagt ttaaatatgc agctggatgc 588421 gattcatgtt catctcgcca aaggcaacac agagagagcg aaggaaatca tacaacaatc 588481 gatgaaaaga gtgaaaagca caatagctga tgcacgttca gctattgacg atctccgcag 588541 caaatcagaa gaaatcggtg ttttaaaaga aagaattacc tcgctaatgg atcattttat 588601 agagtcgaca ggcatggctt gtttattaga ttacagattg catcaggtgc tggatgtgcg 588661 tacagctgaa aactgttatt acatcattgg agaatgcatg acgaatgcgg caaagcatgc 588721 tgaggcgaaa acaatctgga tatccatttg ggatgatgaa aagggaaggc tccatttaac 588781 agttaaggat aacggcaagg gatttgatgt tgaaaaagga aagaaaaaga gaggacatta 588841 tgggcttctt ggcatacaag aacgcgtcag ggcaataaat ggccaattca atatcaagag 588901 tacaaaattg aaaggaacac aaattgagat cactgtacca attcagggag agatgcaaga 588961 tgaataaggt tttaatcgtt gatgaccatc ttgtcgtgag ggaaggtctg aagcttttaa 589021 ttgaaacgaa tgatcaatac accattatag gagaggcgga aaatggaaaa gtagcagtcc 589081 gtcttgcaga tgaattagaa ccggatatca ttctgatgga tttgtatatg ccggagatga 589141 gcgggttaga ggccattaaa caaataaaag aaaaacacga tacccccatc attattttga 589201 ctacatataa tgaagatcac ttaatgatcg aagggattga attaggagcg aaaggatatc 589261 tgttaaaaga tacgagttca gaaacccttt ttcacacaat ggatgcagcc atcagaggaa 589321 atgtgctatt gcagcctgat atccttaaac gtctgcaaga aatccaattt gagcggatga 589381 aaaagcagcg caatgagacg cagctgacag aaaaggaagt cattgttcta aaagcaattg 589441 ctaaaggtct taaaagcaaa gcgattgcct ttgatttggg cgtctctgag cgaacagtaa 589501 agtccagatt aacgtccatt tacaataaat taggcgcgaa ttcaagaact gaggcagtaa 589561 cgattgccat gcaaaaaggt attctgacaa tagacaacta aactgcatat ttgaaaattg 589621 cccaaacgta catgcccgaa tgtacgtttt tttcatttca ttgtcaacta caatgagaaa 589681 gaatgtgatc aagcaatgtg ttgaaaggag attatcatgt caaaaatgtt atatacatta 589741 ggaggatggg ttgctcgcaa tcgcataaaa gcaatatgtg cgtggatcgt tgtgttagtt 589801 gctgcgatag gccttgcagt gaccttgaaa ccaagttttt ctgaggatat gtccatacct 589861 gacacacctt cggaaaaagc gatggatgtg attcaaaaag aatttcctca tggtcctgat 589921 aaagggagca tacgggttat tttcggtgct ggtgatgggg agaaacttac tgggaagcca 589981 gcaaaaaaag caatagaaga tacgttcaaa gaaatcagta aagatgattc tgttgactcg 590041 attgcaagtc cttttgtgac agggacaatc gcgaaagatg gcacagttgc ctatgctgat 590101 atccagtata aatcatcagc agatgatata aaggattact ctatcaaaca cttaaaagac 590161 agtttgaaaa tggctgatga tgaaggattg caaactgagc taagcggaga tgtaccggga 590221 gcggagatgg agataggcgg tgtctctgaa attgtcggca ttatcttggc ttttgtcgtt 590281 ttagccatta cattcggttc tttattaata gcaggtttgc cgattttaac tgcactgatt 590341 ggtttaggtg taagtattgg actggttttg attgggacac aagtatttga tattgcttct 590401 gtcagtcttt cattagccgg aatgattggc cttgctgttg gtattgatta tgctttattt 590461 atttttacga aacaccgcca gtttttaggc gaaggcatac aaaagaatga atcaattgcg 590521 agagccgtgg gaacagcggg aagtgcagtg gtttttgccg gacttactgt tatcgttgca 590581 ctttgcggat taactgtcgt taacattcct tttatgtctg cgatggggct gacagcaggg 590641 cttagtgtac tgatggctgt tttggcttcc atcacacttg tgcctgcggt cttatcgatt 590701 gcagggaagc ggatgattcc gaaatcaaac aagaaaatag aaaaacaaag cactgaaaca 590761 aatgtctggg gacgctttgt caccaaaaat cctatcatgc taagtgtatg cagcattctg 590821 attttgatcg tcattagtat cccatctatg catttggaac tgggcttgcc tgatgctggg 590881 atgaaagcta aggataatcc ggatcgccgg gcatatgact tgcttgccga aggctttgga 590941 gaaggattta atggccaatt aacaatcgta gcggatgcca caaatgctac agaaaataag 591001 gcggaggctt tcgcagatgc agtgaaagaa ataaagggct tagaccatgt agcaagtgtc 591061 actcctgcaa tgcctaataa agaagggaac tttgccatca ttacggtcgt tcctgaaaca 591121 ggtccaaatg atgtcacaac gaaagatttg gtacatgatg tacgcagttt atcagataaa 591181 aacggagtag atttgcttgt tactggatca actgcagtga atattgacat ttcagatcgc 591241 ctgaatgatg cgataccggt gtttgctgta cttattgttg gctttgcgtt tgtattgctg 591301 accatcgttt tccgttcgct gcttgtgccg cttgttgctg ttgcaggttt catgttgacg 591361 atgacagcca ctcttggaat ctgtgtattt gtcttgcaag acgggaatct catcgacttt 591421 ttcaaaatac ctgaaaaagg gccgatactc gcgttcctgc cgattttatc gattgggatt 591481 ctgttcgggt tagccatgga ttatcaagta ttccttgtca gcagaatgcg tgaagaatat 591541 gtaaaaacaa acaatccagt acaagccatt caggctggat taaaacacag tggtcctgtt 591601 gttacagcag ccggcttgat catgatcttc gtttttgcag gatttatctt tgcaggcgaa 591661 gcttctatta aagccaatgg gctggctctt tcctttggtg tactctttga tgcctttatt 591721 gtaagaatga cactgattcc aagtgtcatg aagctgatgg ggaatgcagc ctggtatttg 591781 ccgaaatggt tagacaagat tattccgaat gtggatatag aagggcatca actgacaaag 591841 gaaatacagc cggaaataga tcatgaacaa aagaaacaaa tcagtgtgta atagaaaaag 591901 cagatctttt atgatctgct cttttgctta tggtagtatt tagaagatga agtcggcagt 591961 taaaaggaga cgcttatggc gccatcactc attttcgata tggatggaac tttgtttcat 592021 attggcagaa gctgcatcat actagcaggc atcccaggag aagtgacatg attttttgac 592081 tttgcattca ctacttgatg ccaaggatct tgagaatcct tcttgaaaat aaaggatttt 592141 acaactgatc atataagaaa cctaaagaaa caagcacaca aaaccagctg cgggttttgt 592201 ccaagaaaaa tagagtccat aagagggact ctattttttg aagtgcccgg ctagaagcat 592261 attgcaggac tttatgaatg caaatcacta tcttataagc ccttaccgtg aaatgcctgt 592321 ttctgcattg aaaaaacgca ttacacgttc atttacgtaa gtgggttgtt ccatcgataa 592381 aacatgtccg gcatttttaa tgacttccgc ctcaatatct ggaacgaatg aagaggctcg 592441 gtgcagggct gagtggggat catagatgac ttcatgttca ccaagtaata ataggatagg 592501 aactcttgct gaacgtaatt cctcatcggt aaaaacatac ggaaatccgt cggcattagg 592561 atttggattt cttgatccat cctgccacat tacccctgcc ttaaactgct tcacaaaaat 592621 cgggtgcagc acattctgat cattcatcat ccaatttaag aatgtttcaa ctccatttga 592681 cgctgtaagg ccaagagcgt atttgtagaa atcgtgatga aatggcaaaa acgtttctgc 592741 cggactcagt atagctgcgc tttttactct ctcaggcata cgtaaaagga aattcatcgt 592801 atggagaccg ccaagcgaaa gtccgatcat gtgggacttt tcgatcccca gattgtcaaa 592861 cacatcaaga agccaattgg cgtaatccgt tcttgtaccg cttacattct caggaatact 592921 cttgttttta tcacctatga tatcaactgc ataagttctg tatttactgc tccaatcggc 592981 gatgttggga taccacatcg tcgagctgaa taatgctccg tggagtaata caagcggcgg 593041 ggcatcctct gggccgcttg caatcacatg tgtttgacca aaacgagtag atatatagaa 593101 tgatttacaa cggaccggcc aaagactaag gctttcatta taagtttgat aatagcggat 593161 accgttgtca cttaattcgg gaatactaga tgaatggttt gacatacaaa tgcccctccc 593221 aattttgttt aaatgaatgt gccgtttcgt gatggggaat ctgattttga tataacagac 593281 tttatttaca atataataca gttgttatta gacgtcaaat ccaagatgaa aaggaaaaaa 593341 acgattgaaa cagattattg aaaatcaata taacagaata ttaacctcct ttgtggagcc 593401 gcttcattaa aaccgcaatc caaatgcatg aatcacaaaa atcacaacag gagggatcag 593461 gagggaaggc agcagattca gtgttttgaa cttcttgatt ccaagaatgc ttagacctga 593521 actgaggatg agtatgcctc ccacaattgt gatttcatta ataaggtctg tattgattgc 593581 gctctccatt acttgtgcaa ataaatagat ggagccctgc caggaaaata atacaagtgc 593641 ggcagccgct attccaaaac caaaagttga agcgagcaca atggaggtga tcccatctaa 593701 catcccgttt gtcagaaggt atgtataatc tccatgcaaa gcggcttcaa cagggcctaa 593761 tattgacagc gaacctatac aaaataataa gaccgcagtt gataagccct ctgctaaatt 593821 gcttttagaa aatttgttca ccagcttgtt gaatcgtaat tctaaattga tgatctggcc 593881 tagcaaacct ccaatggcta aactcacgat gaatagaatg gggtatttac tatcaggcaa 593941 atgctgtgta atggcgttga tccccagtgc gaccgcagcg aatcccattg cctgcatcaa 594001 aatatcctgg tattcatctt taatgccttt tttgaatatc cccccgatta tgcttcctgc 594061 aatgatcatc actgtgttaa aaatcgttcc aaacataagc tttctcctcc aaaaatcatt 594121 cctgcataaa aaataaaccc tctagttagt agagagtcaa gggagatcaa aacatattca 594181 tgagattatt tgatgggcag caggatttca gtcacgtaat tatctaggtt attcgtaatg 594241 ccataatcaa tgagtgtgat ttcgattgag tcccctgcta cctcataatg atgttctttc 594301 atatatgcca gtaatttttt gtagtatggt tcggcttctg gatgtgaccc tttaaaccta 594361 atttgcagat attctcttga aggaaagatg atttctgaag aagttttttc attttcatct 594421 tcaagaatca taaatatact ggaatatttg tcaaactgtt ttgctttcac atttgctgca 594481 gaaatggata aaccaatctt gcctatgaat atatcttcgt ttacattcag gtgggttctc 594541 aattcagcta acgaatgttc gatatcatgg ccgagaacat attcatgctg caaataggcc 594601 acacgcattg cgggaagttt gatttttgaa atttgatgta acggcatgtt aacggcatct 594661 tctatatgtg tgatgcgtcg ggagatcttt cgttcaatgc gttccaattc tttcttcttg 594721 cgatcaattt caacctgctg gctttttagt aaatgaagaa gagtgtttgt attttgagag 594781 ttataaaaat caagaagctt attgattggc aggcctaggg ccctcaaata cttgatggta 594841 tccagccgct caaactgttg ggtagaataa tatctatagt tcgtttgctc atctttatat 594901 tccggtttca aaaggccgat ttcatcataa taccgaagag cagagatttt cacattgaat 594961 aactttgaca cttctccaat cgaaaaaaat tccttcattc taacaacctt tctgtcctat 595021 gattgatata cacacattat atagtacggc gagtactaaa ggtaaagttt gcagcataaa 595081 gaaaaaactc cttctaaaaa ggagcttttc attcttcgaa ataaggattt acatggatga 595141 gcacttcttc tacatctgaa aactgtcttt tgatttcatt tcgaatttcg cgggcaatgt 595201 cgtgtccctg cttaattgtc aaatcatgat ccaaagataa acggacatca agcaatttat 595261 agtggccatg ttctcgcgcg cggattctat caattcgttt tacctgatca cattgaaaaa 595321 taacagcttt atattcctct atcagctcgg gatcaacact cttttccatg agcacatcaa 595381 cagacggcct gattaattcc attgaaatct taaaaatgag gtaagcaacg attgcactgg 595441 caatggcatc ggcgtacaac agataggacc atccacggct gtttccgatg atagccaaca 595501 ggacgccgat aaaagcggca agagaggcaa cgatatcgcc tttatgatcg tacgcaatcg 595561 ctataatcgc tttgctgttc cattttttcc cttgctttat agaataacga tataagattt 595621 ccttagccac gtacgaaatc agagccgcaa acaatgcgct gtattgggga acgcttggcc 595681 ctttaacaaa ggacagaatc gcttctatga ggatataaac ggatacgatc actaagataa 595741 ttcctacaat cgcctcacta atgacttcag cttttccgtg accaaaagga tggtcttgat 595801 cgggcggttt attggaaatt ccgatcactg ccaagactgc aatcgaagca acgacatctg 595861 ccgcggaatg tattccgtct gcaaacacgg cttcactatc gcctaccagc ccaaaaaaga 595921 cctttcctgc cattaagatc agattggcga tcaatgcaat caaagcaact tttctgctta 595981 tttgttctct ttcacttgcc attttttcct cctataaaac tgcacaaaaa aataggagtg 596041 ctctatatac gctctccgta tcctttcctg tgtaatcact ttgtttatca taccaattca 596101 atttcgagtg ggtctatagc aacgttgttt cctgtttact aataaataag gtgacagaaa 596161 aaaagttgga gctatgctaa aaaggtcata cagcaaacaa atgagttctt atgtaacaac 596221 agtgatgatt cgctattaaa atgctgccgt cagtgaaaaa tttccaccta attttcaaaa 596281 acctattgac atgagaagat ctgtatttta ctattatctc atattcaaga tattttaatt 596341 tgagatattt ggtcggaaag atcagcgatc aagcgcaact ctaagtgttc aatcgttgtc 596401 agttctttta cacaatattc aatatgattt tttataacat aatatctcga attcgagata 596461 aaagggagtg tagcgtaatg gctgaattta ctcatttagt caatgaaaga cgatctgcaa 596521 gcaattttct ttcaggtcat ccaatcacaa aagaagatct caatgagatg tttgaattgg 596581 ttgcattggc accatcggct tttaatttgc agcatacaaa atatgtgacg gttcttgacc 596641 aggacgtaaa ggaaaagctg aagcaggccg caaacggaca atataaagtg gttagctctt 596701 ctgcggttct cttggtatta ggggataagc aggcatatca acaagcggcc gatatctatg 596761 aaggtttaaa ggtattgggg atattaaata agcaagagta tgaccacatg gtgcaagaca 596821 ccgtttcgtt ttatgaaaac aggggagaac aatttaagag agatgaggcg ataaggaatg 596881 cttcactttc tgcgatgatg tttatgctga gtgctaagga aaaaggctgg gatacctgcc 596941 cgatgatcgg ctttgatgcg gaagccgtaa aacggatttt gaacatagac gaccaatttg 597001 aggttgtcat gatgattacg attggaaaag aaaaaacaga gagcagaaga ccgcgcggct 597061 accggaagcc tgtgaatgag tttgttgagt atatgtaaaa ggagcggata aaaatggcta 597121 aaaaaacgat gggaattcat catattacag cgattgtcgg tcaccctcaa gagaacacag 597181 atttttacgc aggagtgctt gggcttcgtt tggtcaagca aactgtcaat tttgatgacc 597241 caggtacgta tcatctttat tttgggaatg aaggcgggaa gccgggaaca atcattacct 597301 tctttccgtg ggccggagcc cgccaaggcg tcattggaga cggtcaagtt ggcgtgactt 597361 cgtatgtcgt gccgaaaggg gctatggcat tttgggaaaa gagactagaa aagttcaacg 597421 ttccctacac caaaatcgag cgctttgggg aacaatatgt agaatttgat gatcctcatg 597481 gactgcactt agaaatcgtg gaaagagaag aaggagaggc taatacgtgg actttcggag 597541 aagtaacgcc cgatgttgcc attaaaggtt ttgggggtgc aaccctatta tcagagcagc 597601 ctgacaaaac cgctgacctt ttagaaaaca tcatggggct ggagcgagtc ggcaaagaag 597661 gagacttcgt tcgttatcgt tccgccggtg atatcggaaa tgtgattgac cttaagttaa 597721 cgcctattgg ccgcgggcaa atgggggccg gaacggtgca tcacatcgct tggcgggcta 597781 acgatgatga agatcagtta gattggcaaa gatatattgc ttcccacgga tatggtgtaa 597841 ctcctgttcg ggatagaaac tactttaatg ccatttactt cagggaacac ggggaaatcc 597901 tgtttgaaat cgcaactgat cccccaggct ttgcacatga tgaaacacag gaaacaatgg 597961 gcgaaaaact gatgctgcct gtgcaatatg aaccgcatcg cacacaaatt gaacaagggc 598021 tgctgccgtt tgaagtaaga gagttagatt gatttgacac ataaaaaata aagaaacata 598081 tattcaattg atgattgctg gatggtactg tcagcaaaga atcagataaa atcaaagatg 598141 aggagagata caaatggaag atgcaggact gttgcttatt cgtataatga ttggtgtggt 598201 gtttttgttt tatggcacac aaaaattatt cggctggttt ggcggatacg ggattaaagg 598261 aaccggacaa tggttcgaat caattggggt gaaaccagga aacgttgcgg ccgctctatc 598321 aggtcttggg gagttagtaa gcggaattct atttatttta ggcgtattcc tcccgcttgg 598381 agctgctatc ataacaatca tcatgttagg tgctatcgta aaagtccatg gagcgaaagg 598441 ttttgcgaat ggcgccggag gttttgaata taacctggtg ctcattgcag tttccatagg 598501 ggttgcactc atcggttcag gagcttacgc tttgcatttt taatacgaaa gtatgtaaga 598561 acagttgctg cttgtcagta actgttcttt tattttcaca ttttcggcaa gcttgcaggt 598621 actctgcaaa gcaaaaaagc ggatatcata aatataaatc tgtatagtga atgatacgta 598681 ttgatgagct tggtcatgaa aaacagacct atttgaagga gtaaatggat gaaagagatg 598741 acaggattac attcattagt ttctatagaa aactttatca aacagcacaa attcagtttt 598801 atttatatat caaggcctgg ctgtacagta tgtcacgcag ttctgcccca gctcagaata 598861 gtattggatc agtttccaaa catcaaattg gggcatatca atgctgacga tgtagcagag 598921 gtcgccggca gattttcagt tttcaccgtt cctgtgcttc ttttgttcat tgatgggact 598981 gagtttctaa gagaagcccg ttttgttcat tttgaacagc ttgaacaaaa gctgaaaagg 599041 gtttatcgat tatatgaagg cgaataaagg aataaggcaa aaaaagaact caaatgagtt 599101 ctttttttat tcttcactag gcgaagaagg gttatcaacc tgcccttgat cacttgtatc 599161 attatcacaa cttgctgaaa taataattga atgagaagga gagtaatctc ctaatgtgaa 599221 attcactccg taatttttgc tgttcgcagt atggctgttt tgcaagtttt gtccgatatc 599281 tgtattggcg ttttgtgtca ttccatttat cgtgagattt gagatgttga tttgagatcg 599341 catgcttcaa aaactccttt cactcagaag tagctgtcat aaaggacgct ggcagtctat 599401 ttacttctat gatattgcgt ttttatatca ttgcatcaac ataatggtaa aaataatagc 599461 gagtgaatga tcatcttttg aagatgatca acctatcagc agaaataaag ccgcctgata 599521 aagaggcggc agatcgttat atgtcatcta tgaatttgat gtatcgtttt tcgtttgcct 599581 gaaggataag atagtcgttt ttaatgatga gtaggagcct atagcagcgt agccataaaa 599641 ccagcccata aatacgccag aaaagaggct gtgtcgatgg cttatgaaaa cagaaatgac 599701 aaggcctgtt attaaggcaa ctgacggtac aaaagttttg gggattttca ataatatttt 599761 gaggatttgg gttatcaata tgatgattgg aacagctatc acagcatccc aaaagttcgt 599821 gtgaataatt ggaaaagcca tacggcacct catgaagtgt ttatttctta atttttacgc 599881 taaaagcttg gaaagcagct cttggatcgc atatgttaca ttttgggctt gattggcgga 599941 gcttgtttgg cttaaagcat tggattcaaa aaccaaacct gtattactcc caccggaacc 600001 ctctgttgtt ttagacacag agaacgggct gatggaaact gcaaatccgt tattaaaaac 600061 gctgttcccg gatatcgaat gaatataaac tgggaatttc atcattcatc tctcctctct 600121 gttatgactg tttatacaat atggtgtgtg agcagcagtt gcttaaacaa aacggcaaaa 600181 actttcagta agagacaaaa acctgcaaaa tgccacaagc gccttttgtt aatgcagctt 600241 tttagggacg ttttttttat tttttttgcc aacttcatca aaaatattct gattgccaga 600301 ctgggcttgt ccgtccttat ttatgaaatc ggggtgaatg agttttttca gatccctgac 600361 tgttaaaggc ttggcgtcat cagttaattc tattcctaat tgcccgtttg cctctaatgt 600421 cgcaattttg acatcttgta tagccgtaac gccgtgaagc cttagctgca tttcaagctg 600481 gtcagctgta agtctcatct tctttaagtt ttcgatatga agctgtccgt tttcaatgac 600541 gatttttgct tttccggtta acatcttttc aatggtgttc gatttcattt ggatccattc 600601 cataacgatg agtgtgcttg tgaaaattgc cgctgcaatt aatgttttga agaggctgta 600661 ctcgatgatt ggctgaacga taatagttcc gatcgaaatc atgacaaccg tttgagtcga 600721 cgtcatttgt gcgattgatt tccttcctga aattctcagc aaaatgaccc cggctacaat 600781 gagaacaaga gattcccaag tgaaattcat gctaccacct gaccaatgat gaattagatt 600841 tgtcatggga ttggcttttc ttccggccaa tcgcaattta atatatccga aaggcagtcg 600901 gttcattctg tcctgaaccg aacaatattt ttggtataga tggatatatt aagccaaaca 600961 atgatagcaa caggagtttt ttggccgaaa caatctggga agcggggagc gccataacat 601021 gattgaactt gaagttgtca ttagaacggt tgccagcttt ggcttgctgt taatcgcaga 601081 acgaatttta ggcaaacaga caatctctca aatgacgatt tttgatttta ttgcggcgat 601141 cacactaggg gcgattgctg ccggattagc ttacaatact tcaataaaac cgcacaatat 601201 ggccatttcg tttagtattt ttgtgctaac catttttcta atttcgtttc tgtcgataaa 601261 gaacaggaag ctgaggaaat tttttgccgg agatccaaca gtgctgattc aaaacgggaa 601321 gatacttgaa tcaaatatga ggaaaatgcg ttacacactt gattatttaa atcagcaatt 601381 acgggaaaaa gaaatattta atatcgaaga agttcttttt gccattcttg aaacgaatgg 601441 tcagctgact gtgttaagaa aaccgcaatt ccggcatgtg accaaacagg atttaatgat 601501 tgcggtaaac caagaacaaa ggcttccgat agaacttatt atggacggag aaatcattga 601561 gaataattta aagcagaatc gtttgacgga atcctggctt ttggaagaat tgcgaaaaag 601621 agacataaag gtgaaagaga ccgtgtacgc agtgctgctg ggtaatgggg atatttatgt 601681 ggatcaatat aaagaccata tatcagtccc tatggataag gaatgaagga acaatcaatc 601741 ttaaagcccc ttattgaacg caacggtttc aacttgtctt gggtacgaaa tatgcagaag 601801 cccgtttaac agctgaatct gtaacaaatg agtttcagcg gcttcgggaa gctgaatgat 601861 tcgctcaatt tctccgtaat accgttcacg cagcacttcc atttcggctg gaaaaacagg 601921 cgtgatcgtt cctttgatca gcagctgggt tttagacagt aaacggatcg ttaattcttc 601981 ctcatacaca ccgggcattt ccacaatgat aaaattatat tcctcatctt gataaaagtc 602041 gtaaacaaac gtagaagctt cggaatcaaa aaaatgttcc ggggctttat atttgagcac 602101 atttgtccaa aagtcacttt gtttatattc attcgtaatc tcaagccact ttcgaatttt 602161 ttcgaaatcc atatgagatt ctccttaaat ttgatttgaa atcggcgcag aagggtttcc 602221 gatttggtct tggtcactaa cgtctgaatc aatatttcca gtgtttaaaa gtgaagacgt 602281 aggcgaaaga tcccctaagg aaaagtttgc tccaaaatat ttgctgttcg cagtatggct 602341 gttgtgcaca gtcggaccga catctatatt tccgttttgc gtgacgccgt tgatcttaat 602401 atttgcgata ttaatttgat atggcataga cgaaacccct ttaatctaaa attggcggtg 602461 gtgcaatcgg aggagcatta acgttggatg tatcagagtt gccgatagat gtctggtcat 602521 ttacatcagg atcgtttaag aagttttcca ttacggattc tgtaggtgat gtatcaccga 602581 aagaagagtt ggtcccttga gatttttgat tgttggtagg gctgttataa gcagcttcgc 602641 ctattgtaat tgaaccattg cccgaaatac tgttgatctt caaataatat aggttgatta 602701 ctgtagacgg catcccatca cacccttcca tctttctgta cagtacatta tgcgccgctg 602761 cacccaattg ttccttgcat ttacgggcaa aactctatct ggccccggag tgatgctcaa 602821 ttatcagtga atgaaaagcc attgatatag gaatcaatga attgattcag ttattcgaaa 602881 tgcatgagac cttttaataa aggaagctgg caaacaggat cagtttgaaa taattgacaa 602941 tgaagctaat gccatgaaat aatactcgtg agtaacatta ctcgtgggta ttatttttgg 603001 ggtggtccta gttgaaaagt aaaggagtag aaagccgaaa acgattactt aaagctgccg 603061 ctaatgaatt ttcggttcgg ggattccatg acgcgaaggt aagtgaaatt gtgaaaaaag 603121 ctgggttcac gcagccttca ttttacctgt actttcaaag caaagaagcc atctttgccg 603181 agttaataac cgattttcac tctcgagtca gaaagctgac agagtcactt cttctggaaa 603241 acggattaaa cacggaggat gtgtcaaaac gggtactgct agctgtagag actgtttttc 603301 aatttttgga tgaggacaag gatttaacca agatcggctt ttttctcaac ccggaagcaa 603361 aacaaatgaa aaaagacttg gcgatggttt tgaaagagaa cttagaagca gaacagcggc 603421 ttggctattt tcactctgaa ctggatatgg aaactgtcgc tgagtgtttg gtcggcatga 603481 ttgaacattt aaccgaatca tttttgttaa ccggaatcaa agatccggca agcctcgcag 603541 cagaggttgt gaatctttta atttacggga tgcttccgaa agggaatgat gtaagatgat 603601 atctattatg atgaaagtca gtttggcagt ttttatgctt gcgggaggca tcataaaggt 603661 aagccgcgtt ccctttcaag ttgagcattg gcggcattat caatatccat tatggtttct 603721 gactgttact ggcattcttg aaatagccgg ggcacttgct atgacagcgg gaatttggaa 603781 tcggtatgca gcaattggag caggtgttct gtttgtcgtt ctcatggcgg gagcaattca 603841 tgcgcatatg tttcgagcaa gacaatctgt catcatggcg atacaagcga tgatttgttt 603901 gattgtttca atcatgatca tcatggggag ttacacgtaa gcttttcact aatgtttaag 603961 aacaagccca tttgcaggaa atctcctttt cttatcgaat aatagaaagt ccaggaatta 604021 actgaatcag taaaatagag ctccatttct gtgttattcg tccggcatca gctgggcttt 604081 ttttataaag gaggaataca ggatggcatt cactttggaa gacatgactg aggaagagtt 604141 cgaagccttt cgcgggatgt ccgtgcaaaa ttttgcgaaa caaaacataa cgtcaggaac 604201 ttggacggaa aaagaggcat ttgagaaatc ggagcaggca tatgagaaca tgattccgaa 604261 tgggcgagac agcagcaatc attatttttg gaacatcaca aatgaccaag gagaaagaat 604321 gggctggctc tggctgtatg ctgatccatt acatccgcaa aaggaagcgt ttatctattc 604381 ctttggattg tatgaagcct ttcgcggaaa aggacttgct caattggcgc ttcaaacgct 604441 tgatgaaaga gcaagagagc ttggtgcgga aaggctggct ctacatgtat ttgcacacaa 604501 cgagacagcc gtctatcttt atcagaagat gggctatgcc atgaccaata tacgtatgcg 604561 gaaacagcta tgctgaaaag ccgcttacgt tacccaaata caacatgcct atctggaagc 604621 ggtggcaggg tactataagt catcattaga aagattaagg tcatgggagg cttgaacata 604681 taaagaaaaa ggacaacagc tgttgtcctt ttcaatgccg cttgaacttt ctccctcagt 604741 cttttttgtc ttgatgatcc agctctttta ttcgtttcgt aagctcattg aaagcctgat 604801 caagctcctt atacccttta tcatttggcg tcataaaact gagctttccc agcacttctt 604861 gtctttctgt ctcaagcttt aaccgaagct cctcccgctc atttctttct gaaggaacgt 604921 cgtttaactg cttttcgatg ccgttgtttg agatgacgag tttactgttt gttgtttttt 604981 cgagaaagta tcggtcatgt gaaaccgcca gcaatgtgcc gctgtattgt gacagtgttt 605041 cttccagctg ttcgcgtgac ggcaggtcga gatggtttgt cggctcatct aaaatcagca 605101 cgtctttttc ctccagaata tatgccatca gcttgatctt tacacgctca cccatactca 605161 tatgcttgat cggttcagtc cattgggcgg ctgtaaaacc taagtgcctc atcagatttt 605221 gaacgtgccc ccttgctttg aatgtttcat tctcaaataa ctcttccggt gtttgttcta 605281 aaggcaaatc aaacacctcc tgcgttaaat agccgatgtt tgcggacggc gacacccata 605341 cacttccttc tgctgtttcc tgtcccagaa tgatgttcag taatgtcgtt tttccgctgc 605401 cattggggcc tatgatcgca accttttcgc cgtgctgaat tgtaaagttt gcgtttttaa 605461 agagagtcct ttctccaaac gcttttgtta cattctgaac ttctaaaaaa cgttttcctg 605521 ttttgtgggt tgtatcgatt gaaaagcgga ctgtatattc tggggtaacg ggttccgcct 605581 ttgctttttc aagctctttt tcaagccgct tctgcttgga ttttatctgg gcatccgtac 605641 gcttcgcttt tacccggtga tattctttaa acccttcctt tttcgtcgat tgagcatggg 605701 ctttttccga ccaagaagcg agcccattca tttgtgcttc aatccgttca accatttttt 605761 gctgcttttc atattcacgc tgctgggtga gtcttttctt ctcccggaac ttcatatacc 605821 cggagtaatt ccctttgaat tcaatcagcg tctgatcctc aagcgaccat atttttgttg 605881 cggcttcgtc taaaaaatat cgatcgtgag aaacgagaat cacagtgccg ttataatgtt 605941 tcagctgttg gatgagaaat tgcaagcttt tttcatcaag gtggtttgtc ggttcatcta 606001 acagcagcag atctgcatcc tctgatagtc ctttcgccag ccgcgctttc agtttttcac 606061 cgccgcttaa ctgatgaaaa tcacgaagag gcacatgcca tttctccagt aacttctttt 606121 cggcaggtgt ctgatccgca aaggaatacg ccgcggtttc ctgttcaacc aaagccagtt 606181 ttatatcctt ccgaaggatt tgaccctgtg caggggctaa gtcattgtga atgaggtgca 606241 gcaacgtaga tttcccagcg ccgtttttgc cgataatccc aatgatatct ccttgctgaa 606301 cactggcgtt tacatgttta aaaacagttt gatcctttac ttcatagcta acgtttgtta 606361 atgttacgat ctctttcatc catatccctc gctttaaagg gagaataaaa aaatcctccc 606421 aaatgtgttg gaaggattag ccgtgcctgt gcatgatcaa ataagctatt ttttataaat 606481 agcagtgtcg tatatataga aaatgggcag actaatccta ttttttgatt tgaaatattg 606541 atttcaaacg gtaaaaataa gattagttaa tcattgtcca cccatcatcc cttcttgttt 606601 tgattacaaa cactatagca tacctttaaa ttcaaaagca aaggtcattt tcatcaaaaa 606661 aactcctgct ctcatttttg aggcaggagt tttgagtctt attgatgctt cgcttttctc 606721 actttataaa tcacaatcag caaaataaac caaaccggtg tgacaaataa ggaaacacga 606781 gtatcctgtg ccagtgccag cacaaccaga acaaacgcca ggaacgcaag aatcaggtaa 606841 tttgtaaacg gataaagcgg aagcttaaac ttgtttgttt tcgctaattc aggtcttgtt 606901 ttgcggtatt tcatatggca gatgaccgta atcccccaaa tgtagataaa gcatacggtt 606961 gaaatacttg tgatcagggt gaatacgcct tctggcatga tgtagtttaa cgtaacaccg 607021 attaaaatca cgatagctga aaagaataaa gcatttctag gcactttacg ctgagtcagt 607081 ttcgccattg actcaggcgc attgtgatct ttcgccaggg aatagaccat acggcttgta 607141 ctgaatacag cgctgttgca tgctgaagca gcggatgtca acacaacaaa gttgataata 607201 cttgcagccc cgacgatgcc aacagcgaca aatacttgta cgaatgggct ttcgctggga 607261 ttgatgatat cccaaggata gatgctcata atcacgagaa gagccccgat ataaaaaagc 607321 agcacacgga caggaatatt gttgatcgcc ttagggatta ctttttcagg gttttctgtt 607381 tcaccggccg taagcccgac aagctcaatg ccgacaaaag caaacacaac catctggaac 607441 gagaggataa acccgtgcat gccattcggg aacaggcctc cgtggctcca gaggtttgtg 607501 aagctggaca ctcctgagct tgtggaaaag cctttgaaaa tcatcacaag gccaatgacg 607561 attaacgcca aaatggcaat gactttaatc aaagcgaacc aaaattctaa ttctccaaaa 607621 agcttgactg tcgccagatt cataatcagt aaaataataa gagcgattaa gccaggcacc 607681 cattgcggca cacccgggag ccaatattga gtgtagagcc cgactgctgt cagatcagcc 607741 atcgcaatgg aaatccagca gaaccaatat gtccagccgg tgataaaagc tgccatatcg 607801 cctaggtagt cttgtacaaa atccacaaaa gagtgatagt tcaagtttga taacagcagt 607861 tcacccagcg atctcataat taaaaagcaa atgatccctg tgatcatata agcaaataaa 607921 atcgaaggtc cggcaaaatg aatcgatttg cccgagccga gaaataagcc tgtcccaatg 607981 gctccgccga tggcgatgag ctggatatgc ctgtttttca agcctctctg caacgtttgc 608041 tgatttatat tgtctttcgt catgtcgtct gtcactttat gtgttcctcc attgaaaatt 608101 gtttattgag tcagcaatct atttttaatg attattataa cactaaaatt tctatctttt 608161 ttactaaaaa aggattgatg aaaagaattt taatgtgatt tggactattt cccgaaaaag 608221 cggctccatt tagggagccg cttttttatg ctttttcagt ttttgtcata aacaggtaga 608281 gcccgtaatc tgtcggtgcg gatgcgtagc ctgcctgccg cagcattgct gtgatattgc 608341 cgcggtggta tgtcccgtga ttgacaacgt ggggaagcag ttcggaaaca gttgttttca 608401 tgattccgct tgagggattt tgaatctgga gtggcttatt gagctgttct ttttgctgta 608461 aaaatagtat atagcgctcg gataacctca gaaaaaggtc ttccatttcc tctatttctt 608521 tagcctctgt ctgttcttta agctgttcag ctaaagccaa cgcatcgctc aaggttttgc 608581 cggaaaacac ttcaatccag ccgagatcag aaagataaac atgagacaat acatgggata 608641 ttgacggaaa cacgctttga atttcttgat ggtatatctc ttttggaagc tcttttaatc 608701 ggttgaatat ttgttgattg gcccagacgt tatattcata caatttgaat gcaaaatctg 608761 acatgttaaa attccccctt tcgtgtgtat agctttcatt atacacgaac atgagttctt 608821 atgtagagtg ctcgaaaata aaatttgttg acatatatag tttagaggaa taaactaatt 608881 gacattgaac ataaagttta gcggggtaaa ctataatgag gaggggaaga tattgaatga 608941 acaaaagcta tgtcaggcga taaacctgtt tgtggaagtc ctgcttgaag ggacagaatt 609001 tgtgcatcgt gaaatcaatc aggatgtctt caagcatatc tcaagggaac aggcagacct 609061 gttgaaaatt ttaaaagtca agggcccaac ctctcccggc agcctggcca tgtaccaaaa 609121 tgtacataag agcgcgatct ctaacagact gaaaaagctg ctcgaaaagg gattggttca 609181 atgggacgac tgtccggaaa aaagtgatag gcgctctaag cttattaaca ttacacccag 609241 tggtgaacac atactagaag aattagattc tgccatcttt aacgcgctca aaccgttgat 609301 tgatgatata gatgaggaac acttacattc tatcatcgag atattcacca ttttaaaaag 609361 caaatttaaa ggaggagatt ctgccgaatg agagcaatca tcaaattcaa gtgggcaatt 609421 gcagccatag tattagcact taccgtcgtt ttgagtttgt tttctccgaa cttaacggag 609481 ctggccaatc aaaaggggca ggcccagctt cccgctgatg ctgtttcaga aagggcaaac 609541 gccattttaa aacaagcggg agaagacaat aattcgatca gtgtagtctt tacattagac 609601 aacgctataa agaaagaaac agagaatcag ctccggataa taattgataa aatcaaaaag 609661 atcgacggtg tagaagaggt aacatctcct ctgtcagcgg aaaaagaagt caaagaccag 609721 ttgatgtcga aagacaagaa aaccgttctc atgcctgtca cgattacagg ttctgataaa 609781 aaggcggaaa aaattgcgga cgagatttat caaatcgttc ctgatgactt gacggcatat 609841 attacgggag cttcccttat caaccaggat ttcgctcaca gctcagagga agggcttaag 609901 aaaacggaag tgataacagt ctgcctgatc atcggtttac tgttgatcgt gttccgatct 609961 gttgtgacgc cttttatccc gattgtggtt gtcggttttt cttatctgat cagtcaatct 610021 atactgggca tccttgtata caatgttgat tttcctatct cgacgtttac gcaaaccttc 610081 ttagttgcga tcctgttcgg cattggaaca gattactgca tactgcttct tacacggttc 610141 cgtgaagaat tggcaaacgg gcatgataaa aaagaagcgg cgcttatcgc ttaccgcaca 610201 gggggaaaaa ccttatttat cagcggattt gcggtattga tcggattttc cgccttagga 610261 tttgcgaagt ttgcgatttt ccaatccgca gtaggggtag cagtcggtgt gggaatttta 610321 atgatcatcc tctacacact gctgccatta tttatggtga cgctgggtga aaaattattc 610381 tggccttcta agaaagtgct gtcacacagt gataacaaac tatgggcgtt tctcggcaga 610441 cactccgttg cgcgtccgtt tctgttcatt gtcatcacgg tggtgattac gcttccgttc 610501 atcttgacct atgatgacca gatttcattc gactcaactg cggaaatcag cagcgattat 610561 aaatctataa aagctctcga ggccattaag gatggattcg gggaaggaaa agcgttcccg 610621 atcaatgttg tcgtaaaagg agacaaagat cttacaacag ctgatacaat cccctatcta 610681 ggaaatatca gcaaagcgat cgagaaagtt gatcatgttg actctgttat gaccattacg 610741 cagccgactg gtaaaaaaat caaagattta tatattgata accagctagg atcggtttca 610801 gacgggctgg ataagacggt gaaagggatt gccgatgtcc aaagcggatt aacggatata 610861 gaaaacggac tgaatcaaat ggcagggcaa accggctcgg cctcaaatgg agggtctggc 610921 ggttcactgg gcgatgcggc agatggcttg ggcaaaatca atcagcagct gcagctcgtg 610981 agcaaacaga tttcccaaac cggcaatacc gcacagaccg tgcagcagct tacggcaata 611041 agcggacagc ttggccagat tcaaaccggc cttgaacaag cgaaccaaca gctctcaggc 611101 cagcaggcac aagccggaac gctgacagaa agcctgaaaa agctgtccga aggcgtgaaa 611161 agcgcaaatg agggcctgac gaaagtctct gacggtatta cagcttccag tgatatatta 611221 gaggacatga gcaaaagtcc aactgtaaga gatactggca tattcattcc tgatcaagta 611281 atgaaggaca aagactttaa gaagtcaatt gaccagtatt cctttgcaga cggcaaaggt 611341 gttcaattaa gtgtcgttct ggattcaaat ccgtactcag aacaagctat tacgacaata 611401 aaccaaatca aaaaagctgt cgcaaacgaa gttgacggca ctcctttgga gaatgcacag 611461 atcgtgtacg gcggggtcac gagtatgaat gcggacttaa aggagctatc cacaacggac 611521 ttctccagaa caatggtgat tatgattata ggcctgttta tcgtgttaac cattttgttc 611581 cgctcaatga tcatgccgat ttatatgatc gcgtcattgc tgctgacgta ctatacgtcg 611641 atatccataa cagaattaat ttttgtaaac ggcttaggaa acgcgggtgt cagctgggca 611701 gtgccattct tcagctttgt catcttgatc gcgttagggg tagattattc gatcttcttg 611761 ctggatcgat ttaaggaaga ggtgcacctt ggcattgagc aaggtgtcgt caggtcaatg 611821 agcaaaatgg gatctgtcat tattacagct gccattatat tggccggtac gttcgcggcg 611881 atgatgcctt caggtgtcaa tacactgatg caggtggcaa gtgttatcat catcgggctc 611941 ttgctttacg gccttgtcat acttccgctc ttcatcccgg caatcattgc gacctttgga 612001 gaaggaaact ggtggccgtt cggcaggaag aaaggaaaag agtaatcgag agaagagtga 612061 tgaatggtca tcactctttt ttcatgacta aacgactaac ttcagacgtg ttacccaaaa 612121 agatcagacg atcaaacggc ggctgtactt aaaaacaaag agcccggaaa acattcccgg 612181 gctctttgtt ttatttccat tctgcaattg tatcaatcgg cagacggtag gaagcatagc 612241 cttcgtctgc tgcttttccg atagaaagta gcataaccgg tacataacgt tctttatcta 612301 atccgaaggt ttccgcgatg ttttctttat cgtatccgcc gatcgggttt gtatcgtagc 612361 catgcgcgcg tgcagtcagc atcagctgca tggaaacaag acctccgtca atcaggatcg 612421 tttcacggtt gacctgtgcc ggaagctttt caaaatgtgc ggtcagcgcg gcgatttgtc 612481 tgtctttgac ctcctgcggc atgtaaccaa gttccacggc ttttgaatag atttcttcta 612541 gatagtctgc gttgttcatg tctgcaaata cagcgatgac agcagatgat gttgtgactt 612601 gtgtttggtt aaagcttgca agcggtgcga gcttttcttt tccttccggg ctgtcaatga 612661 caagaaaacg ccatggctgc gcgttaacag aagatggggc agttgttgct tcctctaaga 612721 tctctgtcat ttcttctttg ctgattttta ctgccggatc atagttgcgg atagaacggc 612781 ggcctttcat aatttccata aaatcgtttg ttttgatcat gttgatacac tcctcttaag 612841 cttcgatatt atttatattg tttcgcatgc gcgccagcac atcaatgagc aggcggcgtt 612901 cttctgcgct tacatttgcg agcatttcct tcatgaaacg ctccttttcc ttcttagaag 612961 actcaattcg ctctcttcct tggtctgtta accgaacaag ggtgatgcgg ttgtcctcag 613021 gcttgcgccg ccttgatacc atgcctttgg attccagctg tttcaggtgt ctggtaacgg 613081 ctgcgctatc gatatttact ttcttttgaa ggtcgctttg actgatctca tctgcatgat 613141 aaagcaatgt cagcaattcc aaacgagatt ggctgatgcc cgtgcatgcc tcgaacttca 613201 cgccaatcac cttgttcacg ccttgcagct gatataaaat ctcggcttcc tctgaacaaa 613261 atgacgccaa aacccatccc ttctttcctg tcaaaactat taattgatat atcaatgatt 613321 gacacgtcaa ttaatataca acgattgatt tcatcttgca agccatttgc acttttgaac 613381 aacctcccag cgcataaaat tcgctaggct agaacttagc aaaaaaagct ggccgcttct 613441 tcagatgatg ctggtcacga tgattccctg catcattccc atttataggt gttcggaata 613501 tcactttgcc ggcccgtgct caagcggctt tcacaggctg aaagttatga tacaatatac 613561 aaatgtttca cagcttcaat ccatagttgg agctgacatc cattatataa gggactaggt 613621 tgaagggaag gtttgataac atgctgcaca atccaactgg aaaagaacgc ttggcactag 613681 cgtttctgct cggcatgctt gctatattgg gcccgcttaa tatagatatg tatttgccaa 613741 gttttcctga aatcgcgaaa gatttatcag caagtgcttc acttgttcag ttaagtttaa 613801 cagcctgtct ggtcgggctt acgatcggcc agctgattgt cgggccggtc agcgatgcgc 613861 agggaagacg aaaaccgcta ttaatctgta tttttttatt tgcgttatct tctctgtttt 613921 gtgcactgtc gcccaatata acaactttag tggctgcgcg ttttttacaa ggcttcactg 613981 cttctgcagg gcttgtgctg tctcgcgcaa tcgtccgcga tgtgtttacc ggaagagagc 614041 tttctaaatt tttctcgctg ttaatggtca ttaccgcggt ggcgccaatg gttgcgccta 614101 tgacaggcgg tgccattttg cttttgccgt tcgcaacgtg gcatacaatt tttcacgtct 614161 taatgatcat cggattttta ctagttcttc tgattgcatt gaggttaaaa gaaacgcttc 614221 cgctggaaaa acggattcca agctcaatcg gaacatccgt caaaacgatg ggcagcctgc 614281 tgaaggatcg atcctttatg gggtacgcgt taactgtcgg atttattcac gggggaagct 614341 ttgcatatgt gtctggtacg ccttttgtat accaggatat ctacggggtg tctccgcagg 614401 tatttagtat tctttttggc attaacgggc tggcgattat atcgggcagc tttatcatcg 614461 gacgctttgg cggaatcatt catgaaaaaa gcctgcttcg tatagcggtc attacggcta 614521 tgattgcgac ggctgtgcta ttaaccatga ccatgattca cggtcctctt gctacattag 614581 tcatatccat tttcatttac atgattacga tcggcatggt tctgaccagc acgtttaccc 614641 tagccatgga aaagcagggg caccgcgccg gaagtgcaag tgcgctgctt ggaatgcttc 614701 cgctgctcct cggttcaatc gtgtcaccgc ttgtaggcat taatgagaca acagccgttc 614761 cgatgggagc catcatgttt gtgacagctg tcatcggctc actggcgttt tttggattaa 614821 cgaaagaacg agtagggcag aattcataaa aaaacctgac atgacgtcag gttttttgtt 614881 ttatttagaa taacaacagc aggcctgcaa tcgccggagt caaaaagatg gctgatttca 614941 aaaccacctt tggcatgagg ttggtgaatt tcgcgcctac ataggccccg cacattgtcc 615001 cgaccagaac tttgacaagt aaaacgtaat caacaaaacc ttctgtaata tatccgatgc 615061 ctccacctac agccagaggg atgatcacaa gcatcgtcgt tccgacagaa tggcgaatgg 615121 acagattcag cataatcatt aaaccgattt gaataaaagg tgccgacccg atgccgaatg 615181 tgccggaaag aacgccggct gcaattccta agatgaccgc tctcgtatac gttgaaagag 615241 tgctttgatt cacttgagcc ttctctttta aaataaataa tctgattaaa atgagaattg 615301 ctgataaaaa taacattcca gccgtcaaat aatgaagcaa atcagccgga ataaaagaag 615361 tcagcttggc gccgaaaaat gagccaaccg cagcaaagcc tccgactatt aagccgattt 615421 tcatttgaat gttaccctcg cgatagtggc tgtatgcccc tgataagctt gtaaaagcca 615481 tgccggcaag cgaagtgcct aaagccgtat gaatcgggat atggaaaaga agcgttaaaa 615541 gggcaatgac aaagccggct ccaccggcgc caataaagcc taaaataatt cctagaagaa 615601 acataacaag aataatgagc atattttttc ctccattgaa aagatgtaaa aatgtaatcg 615661 tgcgctattc tggcggaggt atggtgtcct attgacgaag aaaaacacgc cgttttttca 615721 gttgccagta gtccgtcgac cgtcgttcag caaacatatc gtacctcaaa ttcagggatc 615781 tgacaaggca gtttgttgct tcccattacc atctgttata tgattttgat gaagaaaagc 615841 ccttgaatat attcaaaaga ggtattatat atggacgatt ttaaattaga taagccgact 615901 ccctactacc tgcaatttta taaccagcta aaaaaaatga tcttcaacgg gacttttaag 615961 cctggggaac ggataaacga aacacagctg gcgaaaagct ttggcgtcag ccgctctccg 616021 ataagggaag ccatgcgatt gcttgagaaa gatggtttgt taaaagcgga tgaccgaaat 616081 gggttttcga tcacgtcgtt aacggcaaaa gatgtagatg agatttataa aatcagaatt 616141 ccgctggagc agctggcagt cgaattagtc atagacgaag cggacgaaga agagctgacc 616201 atactcgaaa aacagcttga agaaacagag aaagcgattc acaacggcac ggaagataca 616261 gaaatcattc gtttaaacca aaaatttcat gagctgctgg ttgatttcag ccataacaga 616321 catttgaaaa atttgcttga gcatgtaaat gacctgattc atttttgcag aatccttaat 616381 tataccggcg accaccgcgc agaaacgata ctgcgtgagc accgcaggat atttgaagaa 616441 gtgaaaaaga aaaacaaaga agcagccaaa caacatgtgc tggctcattt caatcatgac 616501 tgtgagcatt tgaagcatgt gcttgaagaa ggtaaagaga attgatttgt atgatccggt 616561 accaagggag agcagaaccc ttggtatttt tttatgtatt caccacatat ctaagaggcc 616621 ccgttaataa gattttatga tggtttgact aacgaataat gggggttaaa tatgtttatc 616681 catatcgtcg ggcctggtga ttctttgttt tcgataggca gaagatacgg tgcttctgtt 616741 gatcaaatac ggggtgtgaa tggtttagat gaaacgaata tcgtgccggg gcaggctctg 616801 cttatccctc tttatgtata tacagtccag ccgagagata cgcttaccgc cattgcagct 616861 aaagcgtttg tgccattaga gcgactgcga gcggccaatc cgggcatcag cccaaatgct 616921 ttacaagcgg gagcaaaaat aacgattcct tcgatctcaa attacattgc gggaacgtta 616981 agtttttatg tgctccgaaa cccagacctc gatcgggaat taatcaatga ttatgcgcca 617041 tactcgtctt cgatttcaat tttcgaatac catattgcac cgaacggcga cattgcaaac 617101 caattgaatg atgcggccgc tattgagaca acttggcaaa gacgagtcac gccgctggca 617161 acaataacga accttacatc aggaggcttc agtacggaga ttgttcacca agtgctaaac 617221 aatccgacag cgagaaccaa tctggtcaac aacatttatg acttagtttc cacaagggga 617281 tatggcggtg tcacaatcga ttttgagcag gtgagcgccg cggatcgcga tcttttcact 617341 ggatttttac gccagctgag agatcgactt caggcgggag ggtatgtgct gacgatagct 617401 gttcctgcaa aaacaagtga taatatccca tggctgaggg gctacgatta cggggggata 617461 ggagcggttg tcaattatat gtttatcatg gcttatgatt ggcatcatgc gggaagtgag 617521 ccgggtcctg tagcgccgat tactgaaata aggagaacca ttgagtttac gattgcgcag 617581 gtgccgagca gaaaaatcat tatcggagtc ccgctctacg ggtacgactg gatcatcccg 617641 taccagccgg gcacagttgc ttcagcgatt tcaaatcaaa acgcaatcga aagagcgatg 617701 aggtaccaag ccccgataca atattcagcc gaatatcaat caccgttttt ccggtacagt 617761 gatcagcagg ggcggacgca tgaggtatgg tttgaggatg tcagaagcat gagccggaag 617821 atgcagatcg tccgtgaata cagattgcag gctattggcg cttggcagtt aacgctgggc 617881 tttacgccgg gcccatggct tctgcggaaa ttttttacga tcagaaaagt gtaaaaaaag 617941 acaccagagc ttgggtgtct tttttttgat taagtccaga gcagcagaat agttcattca 618001 tttgtacctt gcatgggttg tgttcccatt ttacgattag tagtagtctg atcaaacaaa 618061 gagtcagaat acgatttgag agggagttgt ctacatgaag acagtattga ttttgaattt 618121 tcctgcggaa ggccatgtga atcctacttt aggcattacg aaagcgtttt ccgataaggg 618181 atatgatgtc cattatatat ccactgaaaa atataaaaaa cgattagaag cagcgggagc 618241 aacggtccat cttcaccggg atctgctgcg aacgacacct attcatgtcg gttcgcccaa 618301 tggcattctt gatttcgtga aaatccatat caaaacgtca ttggacattt tacagattgt 618361 caaagactta tctaagagca ttcaatttga ttttgtttat tatgataaat tcggcgcggg 618421 ggaattggtg agggattact tagatattcc aggggtctct tcatcggcgt ctttcctgtt 618481 tggcgaggag catctgaaaa tcctgccgct gcatccggag tctggagcgc cgcttgaatt 618541 ggatcaagag tgcgaagacc ttttggcaaa aatgaaagaa acgtacggtg ttgccccgaa 618601 aaacctggtt caattcatga acaataaagg ggaattgaac gtagtgtata caagccgtta 618661 ttttcagcca gaaagtgatc gtttcgggga tgaatgtcta tttatcgggc cgagctttcc 618721 aaagagagcg gaaaaaacag atttcccgat tgaacagcta aaagatgaga aggtcattta 618781 tatttcaatg gggactgtac tggatcatac agaggatttc ttcaaccttt gtattgatgc 618841 attttcaggc tttaacggaa aagtcgtcat cgctgccgga gaaaaagcgg acctgaccaa 618901 attaaagcag gcgccggaaa actttatcat tgctccgtat gtccctcagc tggaagtgct 618961 ggagcaatcg gatgttttca ttacacacgg cggaatgaac agcgtaaacg aaggcattca 619021 tttcagcgtg ccactggttg tcatgcctca tgacaaggat cagccgatgg tggcgcagcg 619081 tctctctgaa ctccatgcag gctatgtcat ctctaaagat gaagtcaatg cccaaatatt 619141 aaaacaggcc gtagatgagg ttttgcgcaa cgatcagtat acggcaggca ttaaaaaaat 619201 caatcaaagc ttcaaagaat gtatggacat ggaagaagtg atggagcgga ttgatgagtt 619261 gattcgccaa aaaaacaaat aagaaaaaga actcccgtac cttgtacggg agttcttgat 619321 ttaaaacttg attttgattt tttgagcatc actgattttc ttatggttat ggtcaaagac 619381 gtcacttgtc gtgatttcga tccacttgat ctcttttgtt ttcttctcag catccgcggc 619441 cttatcatga gcatggccgc ttgatgcgtt cacaataaag ccgagatttc cggacttttc 619501 ggcgccgcct tccaattcgc cgtttaactc ttcaagataa atatctttgt tccaatcaaa 619561 ggtttcaccc gtatttgttt tcatcaatgc aatcggcgca acatttactt tttttgtaga 619621 ggtgttcttg atatcaacga aaaccttaac gaaatcaaac tcttcatcgt gtgttaactc 619681 atgaaagtaa tcaatcatgc tgtagtccgg gcgcaagtgg atcagcttca tttcttttac 619741 tgttaactcc acgtcgccaa ttttataggt tttgttcact tgtttgatat cttttaagac 619801 agcttttcct ttatcatctg aaaacgtttg gccgacctta tgcaatgtcc ggtcatcagt 619861 tacctgggaa ttaggctgat aatcatctgt gctgtccttc tgggatgaag tgctttgcgg 619921 ctcagctttt actgttttct ccccgcctgc atgctgtttt tcagtactgg cgtttgatga 619981 gcagcccgca agcatgatag caaaaacgag aattgaaaga attcttctca tgatgattcc 620041 tccattaaaa agagatcccg ttacttcata caagcaacgg gacaccttgt attcttttac 620101 ttatcgttaa tcttaatgtt gtattgtaaa gccttgaaaa catttttggc gatttctgta 620161 ttgtcgattt ggccggcaaa tgtctcacta gacggaccgt atgcatagac gggaacatct 620221 tcaccggtat gtccgcctgt tgtccatcca gtgtgagagc gtttattaaa gatgttctcg 620281 attgcgttat cgatatccag tacttccttc gattttgccg cttcttcaac agattgaatt 620341 tcggcttttg ttaaagccaa tttcttttga tcgatatatg ttttcaacgt tttttcaaca 620401 tccgcgccgt cagcgatctt ttctgccata aagtctggtg tgcgctttgc ggctttaatg 620461 ggttcactga accagttgta gatgccgtcc gcaccgatgg aatatccgcc ggttgagtgg 620521 tcagccgttg cgacaaccaa tgtgtgcttg tcttttttag cgaaatcaat agccgcctta 620581 taagcttgtt cgaagtcttc catctcgctc atggcgccaa cgatatcatt gtcatggccc 620641 gcccagtcaa tctggctgcc ttccaccatg aggaagaatc cgtctttatc cttgtttaat 620701 tttttaatgg ctgtgtttgt catatcttta agtgatggaa tatccttcgt acggtcaatc 620761 tttttaggca ggccgccgtc agcgaatagg ccgagaactt ggctgtcttt gtttttcagc 620821 atgtccttgc gatcatccac gtagctgtac cccgcctttt tgaattcctt aatcaaatta 620881 cggtccttac ggtcaaaatt gctctttcct ccgcctagaa ggacatcaat tttgtgcttg 620941 ccgttgacca tctcatcaaa ataatcatcc gcaattgagt tcatattttt tcggctgtgg 621001 tcgtgtgaac caaaagaggc cggagtggcg tgtgtaattt ctgaagtggc cacaagtcct 621061 gttgcttttc ctttttcttt cgcagcttca agcaccgttt tggcttctga cccgtcgtta 621121 tcaacggcta tggcattatt gtatgtttta attcccgcag acatagccgt tgccgccgct 621181 gcagaatccg ttacattttg ttcaggatca tcggggtaag ttgtttgctg gccgacaaga 621241 tactgatcaa aagccgtagg ctccacaact tttgtctttt tattatcctt taagtatcga 621301 taagcagacg tataagacac acccatacca tcaccaatca gaacaataac atttttaatt 621361 tcgtcttggt tccccttttt cttttcctgg gcgctggctt caggcacact gccgctggct 621421 aagctgctga acgcaattga tgataaaacc gcgataggca gtaatttctt cgggaatttt 621481 ttcaactgga taacctccta aatatagatg aatctcaatg acaacccaat tatattttta 621541 aactgttaag ctagtattaa tcgattttaa agattggatt tacaagaata atgaactggc 621601 acccttaaat aatggttatt cttttatgag aagttttaga aggaaagagc gatagtacta 621661 aagaaataaa ttggaggaat agatactggc cgtggatagg cggactgaaa tctgctatag 621721 tcgcatagaa gcaacccgct tacatcttga acaatttaaa gtattacgtt ggaaagaggt 621781 attgtgtaag cacatgtctg agcagttcat atggagtggc atcattttat tttaggaggg 621841 aacaacatgg acgttttttc tgagtactta gcggggattg ctgacccgtt ccaccgagaa 621901 agaacggaag aggtgttaac ttggataaaa aataaatatc caaatttaca tacagaaata 621961 aaatggaatc agccgatgtt tacggatcac ggtacattta ttattggctt tagtgtttct 622021 aaaaagcatt tagctgtcgc tcctgaaaaa gtaacgatag cgcacgtaga ggatgatatt 622081 gtgaaggccg gatatgatta caccgagcag ctgatacgta tcccttggaa cggtccagtt 622141 gattatacgc tacttgagaa aatgattgag tttaatattc tggacaaggc ggactgctcc 622201 actttttggc ggaaatgaag aaaaaggcat aacatatgag ctgtataaaa tatgttacgc 622261 cttttcattt gtctattttt cgttttgatc atctattgct gcttttcatc aaacaaggtc 622321 ttttcattga gcgtaagctg actcgcagaa taatgattac cttgtttcca tttcacttca 622381 atcgtaatat catggccttc aagctcatgt tcatctaacc gctctaaaaa agaaacggac 622441 ttttcttttg cgcttccatc agaaaaagtg cctccagcat aatcatgcat cgggatttcc 622501 gtgtcagaac tcagcagaac ttcatcatcc ttttttacaa tcagtgattc cagataagtg 622561 ttgtctattt caattgtatc accgatccaa taaagtttgc cgctgtattc attcggtgca 622621 tcttcatttt ttgtgaaaac agcttcccaa ttctgatctt tgctttctcc ctgccaattt 622681 ggatactcca aacgaacatg atgaatcagg tgataggaaa aaaagatcaa gcagaaagcg 622741 attaatagga atgccgtgaa aatgagaggg tatttataat gactggacat aaaagactcc 622801 tattcgttta atcaattacc ttcgaaaata gaatttcatc ccgaatcaaa atgccgtttt 622861 cagccacctc gggaatctcc ggcttgagtc ggcgcgcttt ttcaactgcg ttcggaaaca 622921 ctgcggcgaa ttgatagcct ctcttttgat aaaacgctat cgcatttaca ttatcattcg 622981 ttgtgataag ctttattcgt tgacaatgtg catgtttagc cttctcttca acctgctgaa 623041 gtaaagctgt gccgattcct ttattttcaa tcatactatc taatgaaata atttcacaat 623101 ctttcccatc tattgtgtat gtaatacagc caatgatttc gccgctttca tttactgcgg 623161 caaatccatc taattcatca caccgaaaaa tgccgctgga aatcgccatc tcgggtgtac 623221 cccaatgctt ggcaaaaaaa tcggtcaaca tatgtttcgc tatctcattg tttgggatga 623281 tgatcatcat aacactcctc tattgaaaga ttgcatatgt actatcaata taaacaatat 623341 ataacaaaaa aaatagatgt tgaggtgacg gcatggaaat cagcgatatc atttacgggc 623401 agcaccatat agacggagtg ctggaagagc ttatcaaaag cgctcctgtg caaagattaa 623461 aaggaatcta tcaaggcgga gcaagctttt tagtcaatcg aaagtggaat gtgaccaggt 623521 atgagcactc catcggcgtg atgctcctca tcaaaaagct cggaggaacg atagaagaac 623581 agattgcggg tctgctccac gacgtatcac acacagcttt ttctcatgtg gtcgacgttg 623641 tctttgaaaa tcaagcagaa gactatcatg aaaacatctt tcaacaagtc attgttcact 623701 ctgaaatccc ggacatttta caaaaacacg gctatcatac tgaagaactt ttatctgacg 623761 attcaaggtg gacattgctc gaacagcccg caccggagct gtgtgctgat cggacagact 623821 atacgctgcg tgatatgtac cgatatggac acattaacct gcacgaagcg caaacctttt 623881 tggatcatct tattgtgaga aacggaagga tgtttcctga tagtattgaa gccgccgaat 623941 ggtttgtcag tgtgtactac aaggaagtaa ttgatttctt tttgaatcct gtgaatgtat 624001 atggatatga atatttagcg cgagcattga aggcagcgct gcggcatgat gtcatatctg 624061 cagaggatct gctgaaaacg gaccaagagg tactgaacat cctgcgtgca tcaaaaaatg 624121 aagaagtcct gagcttgctt acatccattc atcccggcat acaagtaata gaggatgaca 624181 tccagtacga tttccatcaa aagaagaaaa tgcgcctaat cgatccatcc atttttcttg 624241 atgacaaatg gatcaaatcc tcaggtgttt ctgaaaaggt gaggaaaatg ggtgaggccg 624301 cttatcaaaa agcaaaaaaa ggtgtgtata taaaaatctt aaagcagtaa ttgccgcctg 624361 acagcggctt tttttatgtt tggctttgca aacaaagggg aataggacaa actgcgggaa 624421 cgctttatga gaatatcagc gtatttacat accgttcggg ggtatagtat tatcgagagg 624481 gcatgttttc attgtctgcg ggcaaaagtt acaggaaaaa aatgaagcaa aggagaatga 624541 acatgaaaat ctctaaatat gcactgggaa ttctgatgtt atctctagtt tttgttttat 624601 cagcatgcgg caataacaac agtacgaaag aaagcacaca tgacaatcat tcagactcct 624661 caacacatga agagatggac cattccggat cagctgacgt tccagaggga ttacaggaat 624721 ctaaaaatcc gaaatacaaa gtaggcagcc aagtaatcat caatacttct catatgaaag 624781 gcatgaaagg tgctgaagct acggtaacag gcgcctatga tacaacggcg tatgttgttt 624841 cttatactcc gactaatggg ggacagcgtg tggatcatca caaatgggtg atccaagaag 624901 aaatcaaaga tgccggagat aaaacgttac aacccggaga tcaggtgatt ttagaggctt 624961 ctcatatgaa aggcatgaaa ggagcaacag ccgagatcga ttccgcggaa aaaacaactg 625021 tatacatggt tgactacaca tcgacaacga gcggcgaaaa agtgaaaaac cacaaatggg 625081 tcacagaaga tgagctttca gctaaataat aaaaaatcct ccttttacaa ggaggatttt 625141 tttgctgttt gaacaggtct tgttaaagaa atgaaagcaa acaggacagc gatgatcaca 625201 atcgatccgc cgcaccatgc cgttgacacc acagtacccg tctgatccaa aacaacaccg 625261 ccaatggctg agccaagggc aattccgact tggagggccg atgtgttaaa gctttgctga 625321 atgtcagacg aatcaggtgc aatttcaatt aaatagcttt gctgagccgg ggcgaggctc 625381 cagctcagaa gaccccaaat caccatgaca ggcaaaaaga aaatcataga cgatgtagac 625441 agcggcagta agaacataat gatggcaaag gaaccggtca ccagcaaaat gctcttaaag 625501 gaaccaagcc ggtcagatag cgctcctccg aaagggcctc cgcatacagc agatatcccg 625561 aaaaggaaat aacaaatgct gacccagaaa gagctcaggt gaagagtctc ttctaaaaac 625621 ggcgcaaagt aagcgtaaag cgtgtagtgg ccagctaatg taaacatcgt gacgaggtgt 625681 gaactcgcga ttttcagatt accgatcgtc ttgagttgtt cccggaaagg aatcattttc 625741 tccgccggta ttctttcaaa gaagattgaa ataatcagca tggagatcag tgccaacagg 625801 ccgatgccaa ggaacaaaat ccgccacccg aaggaatcgc tgattaagat tccgagcggc 625861 acgcctaatg cgatagcaga gctgaatccc ataaaaataa ttccgattgc gcgggctctg 625921 tattcaggcg ctacaatttt cggggcaatt gttaaagaaa gcacaacaat cagccctgta 625981 ctcattgctg ccaataccct agataccatc agtgttgcga aattagggct gaaataggcg 626041 acaagattgc taaggaagaa aacaaataaa gcaattagat ataagcgctt ccgctcaatc 626101 ttcgcagtca atgccaaaag cagcggccca gatactgcat atcccagcgc aaacacactg 626161 atcagctgtc cggctgaaac aatggaaatg tctaaatcat ttgcgatctg aggaagaatt 626221 ccccccacaa ttaactcaac caatccgact gcaatcgtag aagctgcaag caggaaaact 626281 ttgaaattca taacaaactc ctttacttaa atgttttgat aaataaaaaa aatcctgatt 626341 acaaaaaatg tcataaacaa attttgtaat caggatttta cggttcctgg tagacaccct 626401 caaaccatat tattgaggtt atacaagtga taatagctat ttaattgatt cgtttccgtt 626461 gatgagtgta ccacattatg aatgaatctt ccatagaaaa atttataaaa cggtgaaccg 626521 gaaaaaaata tgattatatt tattttataa aagtatagac atttaaaatt aaatgactat 626581 aataatcaat gtaagcgttt taataacagg ggggatagca gttgaaaaaa atattactcg 626641 cgtgcagttc aggaatgtct accagtttat tggtgacaaa aatgaaggaa tacgcacagt 626701 ctatcggtga ggaagcggag atttgggctg ttggccagga taaagcaaaa gaagacatga 626761 gaaaagcgga tgccgttttg atcggtccgc aaatgagctt tctgaaaagc gagctccaaa 626821 aagaagcaga tcaatacaac attcaagttg aagtcattga catgatggcc tacggaatgg 626881 cagatgggaa aaaagcgtat gagcaggcat tgtccttaat ggtgaatcaa taatggaaca 626941 gatgaaaatc acgaatttaa cagacgagca aatcagtttt cagctaatcc tgcacagcgg 627001 aaatgcccgc agctgcatca tacaatcact gcgcgcctat aaagaaggga aaaaggacga 627061 ggctgatgcc ctcattgcca aggcggagca ggatttatcc gcggcccatg acattcactt 627121 tcaaatgata cagaaggaat ccggcggaga agcaacagct ttttcattgc tgcttatgca 627181 tgcagaggat catctgatgt caacattatc catgaaagaa ttagtgaaag agatgcttga 627241 tctctttaaa accaagaata tataaaaaat cggggtggat agggtgttcg agaaaatcag 627301 ccaattcctt gttccaattg cagggaggtt aaacaataac cgctatttgc aagtgttgcg 627361 tgatgcattt atgctggctt tcccgctgac gatattcggg tccatttttg tcgtgttaac 627421 gaatttgccg tttctaaaca aaatcatgaa cgcctcaatg cttacgtcgt ttcagtctca 627481 tttcggcatt gcctccacgg cgacaatggg cattatgtct gtctttgttg tgttcgggat 627541 aggctattac ctgtcgaaaa gctatcaggt cgaagctgta tttggcggag cgatcgcttt 627601 ggtttccttt ttgctcttaa cgccatttat cattcagccg gaaacaggtg atgccattac 627661 aggggttatc ccggtcgatc gtctcggtgc aaaagggatg tttcttggga tgattacggc 627721 atttctttct ggcgaaattt acagaagaat cgttcaaaaa aacctgacaa tcaaaatgcc 627781 agccggcgtt ccgcctgctg tagcaaaatc attcgccgca cttattccgg cttttatcac 627841 attgactgta tttttgctga ttaacgtaat ggtgactctg ttttttaaaa caaatatgca 627901 cgacgtcatt tatcatgcga ttcaggctcc gcttgtcgga cttggaagcg gtatcattcc 627961 aacactgatt gccgtgtttt tcattcaaat tctttggttt ttcggactgc atggacagat 628021 cattatcaac tccgtgatgg acccgatttg gaatacactg caggtagaaa acctttctgc 628081 ttacacggcg ggaaaagaaa tccctcatat tatttcaaaa ccgtttatgg agatttatac 628141 agtagggatg ggcggaacag ggatgacgct tgcgattgtg tttaccattc tcatattcat 628201 gaaaagcagg cagatgaagc aagtatcaaa acttggcctc gctcccggta tttttaacgt 628261 aaacgaaccg attatctttg ggcttccgat tgtcatgaat ccgatcatta ttgtgccttg 628321 ggtgctggca ccgatggttg ttacgctcgt cacctatctg gctatgtcag ccgggctcgt 628381 tccgcctcca actggtgtga cagtgccgtg gacggttcca ttattcatta atggcatcat 628441 ggcgacgaac tcaatcatgg ggggcgtgat gcagcttatc aatctgctga ttgtcttcgt 628501 gatctggttt ccgttcctaa aagcaatgga taaattaaat ctggcaaaag aaaaagaaca 628561 ggctgtgcag gagacagctg ctcagcaaaa tgataacagc ataaaaatgt gacataaggg 628621 gagagagact tggcacatac agaacaatat cgttttccaa aggatttttg gtggggatca 628681 tccgcttcag caacacaaat ggagggtgcc gccgacagag acggaaaagg ccagaatata 628741 tgggattatt ggtttgaaaa agaaccgcat cgtttttttg atcatgtcgg acccgcagac 628801 acatcccaat tttacgacaa ctataaagaa gatatcaggc tgatgaagga acttggccac 628861 aactcgttcc ggatgtcgat ttcctggtca cgtttaatac caaacggaac gggcgagatc 628921 aacgataaag ccgcagattt ctataacaat gtcattgatg agctgatcgc taacggaatt 628981 gaaccttttg tcaatttgtt tcatttcgat atgccgatgg cgcttcaaaa aatcggcggc 629041 tgggtcaaca gagagacggt tgacgcgtat gaaaactatg caagaacttg cttccgtttg 629101 tttggcggcc gggtgaaaaa atggttcacg cataatgaac caatcgttcc cgtagaaggc 629161 ggatacctat atgattttca ttatccaaac aaggtcgatt ttaaagaggc cgtccaggtt 629221 ggatttcata cgatgctatc aagtgcccgc gccattcagg cttacaggga gatgaagcag 629281 gacggaaaaa tcggcatcat cttaaatttg accccttcat acccgagaag cagccatccg 629341 gcggatgtga aagccgggga aatcgcagac gcgtttttta acagatcttt tttagaccca 629401 tctgtcaaag gcgaatttcc caaagagctg gttgacattt tgaagcatga aggctttatg 629461 cctgattaca acgctgaaga tctcgacatc atcaaaaaga acacggttga cctgttggga 629521 gtgaattatt accagccgag acgtgtgaaa gcgaaagaac atcttccgaa tcccgacgct 629581 ccttttttgc cggacaggta ttttgatccc tacgtcatgc cgggccgcaa aatgaatccg 629641 catcgcggct gggagatcta tgaaaaaggc gtttatgata ttttgatcaa tttaaaagaa 629701 aactacggca acatcgagtg ttttatctct gaaaacggta tgggggttga aggtgaagag 629761 cgattcaggg atgaacaagg catcattcag gatgattacc ggattgaatt tataaaagag 629821 cacctcaaat ggattcaccg cgccatacag gaaggctcga acgtaaaagg ctatcactta 629881 tggacgttca tggacaactg gtcttggaca aatgcctata aaaaccgata cggatttgta 629941 tcagtcaatc ttgagaaaga cggagaaaga accgtcaaaa agagcggaaa atggttcaaa 630001 gaggttgctg agcatagcgg tttctagatt ttcctaaagg tcaagatctt ccggcaatca 630061 tcataacgaa tagagatgac gaaaatccgc aacattgatg aaatagggaa aagaacttat 630121 gatatccgta aaagcttatg tgatatcaaa cagctgccgg aggataccaa tgaataaata 630181 cgaaatcatt gcaaatgaaa tgagaaatag aattaaaaat aacgtatatc cgatcgatca 630241 gcccattcct gatgaagtat ctcttgcaaa agaatttaac tcaagccgca tgacgatgaa 630301 gagagccttg gataatttag ttgccgaggg tctgctgttt agaaaacgag gccatggcac 630361 gtttattatt caatctgcaa tacaggatga ccatgtccat gtagtcagca atgagattct 630421 cggattgacc aacttgctga aagataaaaa aatcaaaagc aaggtcattc agtttgaagt 630481 gcaatttccc actgaggaag tggccgccca tttgtctatt gatcagaaaa caccggttta 630541 ttatgtcgtt cggctgcgaa ttgtagaagg tgaaccctat gtattagaaa aaacatatat 630601 gccgactcat ttaataccgg gcattaatga cgatgtcctt catgattcga tctacaatca 630661 tattacaaat gtgctgcagc tcaaaatcgc cggaacgcat cggaaaatca gagcctgcaa 630721 atctgatcat attgaccagc agcatctggg ctgtaaacag gatgatccaa ttcttgaagt 630781 ggaacatgtg ggcttcttag ataccgggat tccatttgaa tattcctttt cacgtcatcg 630841 gcatgacaag tttgttgtga cttctgtaaa catacggcgc tgattgcgga gacaacaagg 630901 aggccatctg catgcttggc ggtattgaag caggcggcac aaagtttgtt tgtgctgtcg 630961 gtagagaaga tggaacgatc attgacagga tagaattccc cacaaagatg ccggatgaaa 631021 cgatagagaa agtaattcaa tattttagcc aattttcatt acaggcaatc ggcatcggct 631081 cctttggtcc cgttgataac gataaaacca gtcaaacata cggtaccatt acggccacgc 631141 cgaaagcggg ctggagacac tatccctttt tgcaaaccgt taagaacgaa atgaagatcc 631201 cagtcggatt tagtacagat gtcaacgctg cggcgctggg tgaattcctt ttcggtgaag 631261 cgaagggtct tgacagctgc ctgtatataa cgattggcac tggcatcgga gcgggggcta 631321 ttgtagaggg gaggctcctt caggggctgt cacacccaga gatgggccat atttatatcc 631381 ggaggcaccc ggatgacgta taccaaggga agtgccctta tcatggagat tgctttgaag 631441 gcttagcttc aggccccgct atcgaagccc gctgggggaa aaaagccgcg gatttatcag 631501 atatagcaca agtctgggaa ctggaagggt actatattgc ccaagcactg gctcagtata 631561 ttttgatcct tgcacctaaa aaaatcattc ttggcggcgg cgtcatgcaa cagaaacaag 631621 tgttttctta tatctatcaa tatgtaccaa aaatcatgaa cagctactta gatttttctg 631681 aattatcaga tgatataagt gattatattg tacctccacg tttaggcagt aacgccggaa 631741 tcatcggcac gctagtttta gcgcatcagg ccttacaagc agaggcagca tccggggagg 631801 tgcgatcatg acgcatccat tatttttaga gcctgtcttt aaagaaagac tatggggagg 631861 gacgaagctt cgtgacgctt ttggctacgc aataccctca caaaaaacag gtgagtgctg 631921 ggccgtttct gcacatgccc atggctcgtc gtctgtaaaa aatggcccgc tggcaggaaa 631981 gacacttgat caagtatgga aagatcatcc agagatattc gggtttccgg atggtaaggt 632041 gtttccgctg ctggtaaagc tgctggacgc caatatggat ctctccgtgc aagtccatcc 632101 tgatgatgat tatgcaaaac tgcacgaaaa tggcgacctt ggtaaaacgg agtgctggta 632161 tatcattgat tgcaaagatg acgccgaact aattttggga catcatgcaa gcacaaagga 632221 agagttcaaa caacgaatag aaagcggtga ttggaacggg ctgctgaggc gaatcaaaat 632281 caagccagga gatttctttt atgtgccaag cggtacactc catgctttat gtaagggaac 632341 ccttgtcctt gaaatccagc aaaactctga tacaacatat cgcgtatacg attatgaccg 632401 ctgtaatgac cagggccaaa aaagaactct tcatatagaa aaagccatgg aagtcataac 632461 gataccgcat atcgataaag tgcatacacc ggaagtaaaa gaagttggta acgctgagat 632521 cattgtttat gtgcaatcag attatttctc agtgtacaaa tggaagatta gcggccgagc 632581 tgcttttcct tcatatcaaa cctatttgct ggggagtgtt ctgagcggat caggacgaat 632641 cataaataat ggtattcagt atgaatgcaa tgcaggctca cactttattc tgcctgcgca 632701 ttttggagaa tttacaatag aaggaacatg tgaattcatg atatctcatc cttaatgaat 632761 gggggagttg catttgttta agaaacatac gatctctttg ctcattatat ttttacttgc 632821 gtctgctgtt ttagcaaaac caattgaagc gcatactgtg tcgcctgtga atcctaatgc 632881 ccagcagaca acaaaaacag tgatgaactg gcttgcgcac ctgccgaacc gaacggaaaa 632941 cagagtcctt tccggagcgt tcggaggtta cagccatgac acattttcta tggctgaggc 633001 tgatagaatc cgaagcgcca ccgggcaatc gcctgctatt tatggctgcg attatgccag 633061 aggatggctt gaaacagcaa atattgaaga ttcaatagat gtaagctgca acggcgattt 633121 aatgtcgtat tggaaaaatg gcggaattcc gcaaatcagt ttgcacctgg cgaaccctgc 633181 ttttcagtca gggcatttta aaacaccgat tacaaatgat cagtataaaa aaatactaga 633241 ttcttcaaca gtagaaggaa agcggctaaa tgccatgctc agcaaaattg ctgacggact 633301 tcaagagttg gagaaccaag gtgtgcctgt tctgttcagg ccgctgcatg aaatgaacgg 633361 cgaatggttt tggtggggac tcacatcata taaccaaaag gataatgaaa gaatctctct 633421 atataaacag ctctacaaga aaatctatca ttatatgacc gacacaagag gacttgatca 633481 tttgatttgg gtttactctc ccgacgccaa ccgagatttt aaaactgatt tttacccggg 633541 cgcgtcttac gtggatattg tcggattaga tgcgtatttt caagatgcct actcgatcaa 633601 tggatacgat cagctaacag cgcttaataa accatttgct tttacagaag tcggcccgca 633661 aacagcaaac ggcagcttcg attacagcct gttcatcaat gcaataaaac aaaaatatcc 633721 taaaaccatt tactttctgg catggaatga tgaatggagc gcagcagtaa acaagggtgc 633781 ttcagcttta tatcatgaca gctggacact caacaaggga gaaatatgga atggtgattc 633841 tttaacgcca atcgttgagt gaatccgtaa tgtcacaatt aagaaggtgc tcaagaagtt 633901 tcttgagcac cttcccactg gattaagcat tcatatcgcc taacccagga ctgtgttcat 633961 ttggtatttc aggaagcact ggtacgggaa accctgccgg aggatctatt acttgtaact 634021 ctccgccatt tcggcttgga gatttccctt gatagatttc actgattctc gtttcatcca 634081 acctaaagtt aaaatgtgta ttatggtagc ctaattcgac atactttctg cactcaggat 634141 atttattaat gtcataattc ggcacaggga gcagcttcgc ccattcaacg cccaatgtct 634201 cgagcgcttt cgcgaatgca ttctggtgag cattgtcgcg tacaatcaga aaagcaagtg 634261 tttcgcggaa cgtctgatta gagctcattt cataaattct tgttttttgc agcacacctg 634321 tcgactcaag aagcaggtta tccagcaggt cagtaattaa gtttccgtgg ttatacaccc 634381 acgacccgtt ccacggattg ccccctgcat caacaggaag ggaactttgc gctccaataa 634441 tataatgatg aggattagca tgtttaaccg cttcatcaag tggcgcttga tctgtacctt 634501 gactgccgac accttcaccg cctgattcat ctaataaagc attgattgtg ttttgaacca 634561 gttcaacgtg ggcaatctcc tctaaaaaaa tgccgcgaag cagatcgcgg tactgtttct 634621 gctttcctct gaaattagag ctttggaaaa aaactgcatc attgtacgca tttctccgta 634681 atgaccgcct aatatctcct gcaggacctt agcagctgcc gggtctggct tgtccggttt 634741 aatgatatta atcagttcct ctttgtagta atacataaca cgcctcattt cttcttaaga 634801 gattttctta tattatttgt aagatgagat aaaatatata catgataagc atgggaaggc 634861 gtgaaagaag aaaataaaaa aatacaggaa aagtgttgac caaataaaac aggcatggta 634921 tattattaaa cgtcgctgat gaacagcgtg aaacaaaaca gaaaaacaaa aaagttttcc 634981 taaggtgttt acaagatttt aaaaatgtgt ataataagaa aagtcgaatt gaaaaagatt 635041 cgaaaaaaca ttaaaaaact tcttgacttc aacatcaaat gatagtatga tagttaagtc 635101 gctcaataag cgcccgtagc tcaattggat agagcgtttg actacggatc aaaaggttag 635161 gggttcgact cctctcgggc gcgccatata agataccacg cgggtgtagt ttagtggtaa 635221 aacctcagcc ttccaagctg atgtcgtgag ttcgattctc atcacccgct ccattattga 635281 atgatctttg aaaactaaac aagacaaaac gtacctgtta attcagtttt tgaaaatcgc 635341 acagcgatgt gcgtagtcag tcaaactagg gcctgcacga tgcaggtcac acaggtgtca 635401 ccgcgggatg cggtggactt aacctgtgat ccatttatcg gagagtttga tcctggctca 635461 ggacgaacgc tggcggcgtg cctaatacat gcaagtcgag cgaacagatg ggagcttgct 635521 ccctgatgtt agcggcggac gggtgagtaa cacgtgggta acctgcctgt aagactggga 635581 taactccggg aaaccggggc taataccgga tggttgtttg aaccgcatgg ttcaaacata 635641 aaaggtggct tcggctacca cttacagatg gacccgcggc gcattagcta gttggtgagg 635701 taatggctca ccaaggcaac gatgcgtagc cgacctgaga gggtgatcgg ccacactggg 635761 actgagacac ggcccagact cctacgggag gcagcagtag ggaatcttcc gcaatggacg 635821 aaagtctgac ggagcaacgc cgcgtgagtg atgaaggttt tcggatcgta aagctctgtt 635881 gttagggaag aacaagtacc gttcgaatag ggcggtacct tgacggtacc taaccagaaa 635941 gccacggcta actacgtgcc agcagccgcg gtaatacgta ggtggcaagc gttgtccgga 636001 attattgggc gtaaagggct cgcaggcggt ttcttaagtc tgatgtgaaa gcccccggct 636061 caaccgggga gggtcattgg aaactgggaa acttgagtgc agaagaggag agtggaattc 636121 cacgtgtagc ggtgaaatgc gtagagatgt ggaggaacac cagtggcgaa ggcgactctc 636181 tggtctgtaa ctgacgctga ggagcgaaag cgtggggagc gaacaggatt agataccctg 636241 gtagtccacg ccgtaaacga tgagtgctaa gtgttagggg gtttccgccc cttagtgctg 636301 cagctaacgc attaagcact ccgcctgggg agtacggtcg caagactgaa actcaaagga 636361 attgacgggg gcccgcacaa gcggtggagc atgtggttta attcgaagca acgcgaagaa 636421 ccttaccagg tcttgacatc ctctgacaat cctagagata ggacgtcccc ttcgggggca 636481 gagtgacagg tggtgcatgg ttgtcgtcag ctcgtgtcgt gagatgttgg gttaagtccc 636541 gcaacgagcg caacccttga tcttagttgc cagcattcag ttgggcactc taaggtgact 636601 gccggtgaca aaccggagga aggtggggat gacgtcaaat catcatgccc cttatgacct 636661 gggctacaca cgtgctacaa tggacagaac aaagggcagc gaaaccgcga ggttaagcca 636721 atcccacaaa tctgttctca gttcggatcg cagtctgcaa ctcgactgcg tgaagctgga 636781 atcgctagta atcgcggatc agcatgccgc ggtgaatacg ttcccgggcc ttgtacacac 636841 cgcccgtcac accacgagag tttgtaacac ccgaagtcgg tgaggtaacc ttttaggagc 636901 cagccgccga aggtgggaca gatgattggg gtgaagtcgt aacaaggtag ccgtatcgga 636961 aggtgcggct ggatcacctc ctttctaagg atattatacg gaatataaga ccttgggtct 637021 tataaacaga acgttccctg tcttgtttag ttttgaagga tcattccttc gaaacgtgtt 637081 ctttgaaaac tagataacag tagacatcac attcaattag taatacaaga tatcacatag 637141 tgattctttt taacggttaa gttagaaagg gcgcacggtg gatgccttgg cactaggagc 637201 cgatgaagga cgggacgaac accgatatgc ttcggggagc tgtaagcaag ctttgatccg 637261 gagatttccg aatggggaaa cccaccactc gtaatggagt ggtatccata tctgaattca 637321 taggatatga gaaggcagac ccggggaact gaaacatcta agtacccgga ggaagagaaa 637381 gcaaatgcga ttccctgagt agcggcgagc gaaacgggat tagcccaaac caagaggctt 637441 gcctcttggg gttgtaggac actctgtacg gagttacaaa ggaacgaggt agatgaagag 637501 gtctggaaag gcccgccata ggaggtaaca gccctgtagt caaaacttcg ttctctcctg 637561 agtggatcct gagtacggcg gaacacgtga aattccgtcg gaatccggga ggaccatctc 637621 ccaaggctaa atactcccta gtgaccgata gtgaaccagt accgtgaggg aaaggtgaaa 637681 agcaccccgg aaggggagtg aaagagatcc tgaaaccgtg tgcctacaag tagtcagagc 637741 ccgttaacgg gtgatggcgt gccttttgta gaatgaaccg gcgagttacg atcccgtgca 637801 aggttaagca gaagatgcgg agccgcagcg aaagcgagtc tgaatagggc gcatgagtac 637861 gtggtcgtag acccgaaacc aggtgatcta cccatgtcca gggtgaagtt caggtaacac 637921 tgaatggagg cccgaaccca cgcacgttga aaagtgcggg gatgaggtgt gggtaggggt 637981 gaaatgccaa tcgaacctgg agatagctgg ttctctccga aatagcttta gggctagcct 638041 caaggtaaga gtcttggagg tagagcactg attggactag gggcccctac cgggttaccg 638101 aattcagtca aactccgaat gccaatgact tatccttggg agtcagactg cgagtgataa 638161 gatccgtagt cgaaagggaa acagcccaga ccgccagcta aggtcccaaa gtatacgtta 638221 agtggaaaag gatgtggagt tgcttagaca accaggatgt tggcttagaa gcagccacca 638281 tttaaagagt gcgtaatagc tcactggtcg agtgactctg cgccgaaaat gtaccggggc 638341 taaacgtatc accgaagctg cggactgttc ttcgaacagt ggtaggagag cgttctaagg 638401 gctgtgaagc cagaccggaa ggactggtgg agcgcttaga agtgagaatg ccggtatgag 638461 tagcgaaaga ggggtgagaa tcccctccac cgaatgccta aggtttcctg aggaaggctc 638521 gtccgctcag ggttagtcgg gacctaagcc gaggccgaaa ggcgtaggcg atggacaaca 638581 ggttgatatt cctgtaccac ctcctcacca tttgagcaat ggggggacgc aggaggatag 638641 ggtaagcgcg gtattggata tccgcgtcca agcagttagg ctgggaaata ggcaaatccg 638701 tttcccataa ggctgagctg tgatggcgag cgaaatatag tagcgaagtt cctgattcca 638761 cactgccaag aaaagcctct agcgaggtga gaggtgcccg taccgcaaac cgacacaggt 638821 aggcgaggag agaatcctaa ggtgatcgag agaactctcg ttaaggaact cggcaaaatg 638881 accccgtaac ttcgggagaa ggggtgctct gttagggtgc aagcccgaga gagccgcagt 638941 gaataggccc aggcgactgt ttagcaaaaa cacaggtctc tgcgaagccg taaggcgaag 639001 tataggggct gacgcctgcc cggtgctgga aggttaagag gagcgcttag cgtaagcgaa 639061 ggtgcgaatt gaagccccag taaacggcgg ccgtaactat aacggtccta aggtagcgaa 639121 attccttgtc gggtaagttc cgacccgcac gaaaggcgca acgatctggg cactgtctca 639181 acgagagact cggtgaaatt atagtacctg tgaagatgca ggttacccgc gacaggacgg 639241 aaagaccccg tggagcttta ctgcagcctg atattgaatg ttggtacagc ttgtacagga 639301 taggtaggag ccttggaaac cggagcgcca gcttcggtgg aggcatcggt gggatactac 639361 cctggctgta ttgaccttct aacccgccgc ccttatcggg cggggagaca gtgtcaggtg 639421 ggcagtttga ctggggcggt cgcctcctaa aaggtaacgg aggcgcccaa aggttccctc 639481 agaatggttg gaaatcattc gcagagtgta aaggcacaag ggagcttgac tgcgagacct 639541 acaagtcgag cagggacgaa agtcgggctt agtgatccgg tggttccgca tggaagggcc 639601 atcgctcaac ggataaaagc taccccgggg ataacaggct tatctccccc aagagtccac 639661 atcgacgggg aggtttggca cctcgatgtc ggctcatcgc atcctggggc tgtagtcggt 639721 cccaagggtt gggctgttcg cccattaaag cggtacgcga gctgggttca gaacgtcgtg 639781 agacagttcg gtccctatcc gtcgcgggcg caggaaattt gagaggagct gtccttagta 639841 cgagaggacc gggatggacg caccgctggt gtaccagttg ttctgccaag ggcatcgctg 639901 ggtagctatg tgcggacggg ataagtgctg aaagcatcta agcatgaagc ccccctcaag 639961 atgagatttc ccattccgca aggaagtaag atccctgaaa gatgatcagg ttgataggtc 640021 tgaggtggaa gtgtggcgac acatggagct gacagatact aatcgatcga ggacttaacc 640081 atatttttga atgatgtcac acctgttatc tagttttgag agaacactct caatttgttt 640141 ggtggcgata gcgaagaggt cacacccgtt cccataccga acacggaagt taagctcttc 640201 agcgccgatg gtagtcgggg gtttccccct gtgagagtag gacgccgcca agcattactt 640261 ttatcatcgc ggggtggagc agttcggtag ctcgtcgggc tcataacccg aaggtcgcag 640321 gttcaaatcc tgcccccgca accaaatata tggttaaata aggagtgccc taagggtgca 640381 accaaaataa tcctatacaa atatggtccg gtagttcagt tggttagaat gcctgcctgt 640441 cacgcaggag gtcgcgggtt cgagtcccgt ccggaccgcc attaatgtaa acgaaacgat 640501 catgttttcg ttttttttgt gttttctttt actgtatctt ctgcttggtg tcatagccaa 640561 gctttcttta tatcgggaac atcttggata ttccagcaaa attcgataaa ctaggaagag 640621 cacaaatagg cataagcagg gttgaaagga ggttttggtt catggatgaa tttgatttga 640681 tacatagcat tactccgcgg accattcacc attcttccgt tgatgtagga ataggtgatg 640741 atgcagcgct ctacactgcg aaacacggcg ttcaggaaat tgtttgtgtt gatactatgg 640801 tagaagacgt gcacttcaaa ttacactatt cctcacctga agatatcggg tacaaggcgt 640861 tagccgttaa tataagtgat attgccgcga tgggaggcat tcctaagttt tatctggtat 640921 cacttgcggt accttcaaaa tggactgaat ctgaaatcaa ggcgatgtat gaaggaatga 640981 atgaactggc gaaactatat catatggatc tgattggcgg cgatacagtt tctaccgctg 641041 acaaattagt cgttacagtc actgtaatcg gtgaaattga aaagggacag gcctgtttgc 641101 gcagcttggc aaaaccgaat gatattgtgt ttgtaaccgg tgaaatcggt tcttctgcag 641161 cagggctttc tttattgctg gaagagacta atcctcaaaa ctcatctgtg gaaacggatt 641221 actttatcca caggcataaa cggcctgagc caagagtaag cgtcggcaga ttatgctcga 641281 tttttaaacg ggcagcttta aatgatgtta gtgacggatt ggctagtgaa ctgaacgaga 641341 ttgcagaagc cagctgtgtt tcaattgaaa ttgttgaaag catgcttcca attcattctg 641401 atttgcctaa gcttcatcct aactggaaag aatgggcttt gtttggcggt gaggattttg 641461 agctgacagg gacggtttca aatgaggagt gggaagtgtt gaagcaggag tgcgcagcgc 641521 ttcatcttcc cattacaaag attggctatg tcagggaaaa aacaaaatct aaagtgatcc 641581 taaaaacaga tcaaacatca atgatcttag agaaaaaggg atataatcat tttaaataag 641641 acgggtgact cgtgtgaagc aattaaaatg gagaactgta aatccagaag aaacaaaagc 641701 aattgccaag ctgacggcag cgtttgctaa accgggagac gtcctgacat tagagggcga 641761 tttaggtgca ggaaaaacga cttttacgaa aggttttgca gaagggctgg gaattacacg 641821 tattgtaaac agtccgactt ttacaattat aaaagaatat aacgatggcg tacttcctct 641881 ttatcacatg gatgtgtata gaatggaaga tgaaagtgaa gatttgggac ttgatgaata 641941 ttttcacgga caaggtgtct gtctcgttga atgggctcat ttaattgaag aacagctgcc 642001 acaggagcga ctgcaaattg tcatcaaaag agctggtgat gatgagcggg aaattacctt 642061 tactgctgtc gggaatcggt atgaaatgct ttgtgaggag ttaagtagac atgacaatat 642121 tagcaattga tacatcaaat tatacattgg gcattgcgct gcttcgagaa gacactgtta 642181 tagcagaata cattacatat ttgaaaaaga accactctgt aagagcgatg cctgctgttc 642241 attcattgct gaatgattgt gatatggcac cgcaggacct ttctaaaatt gtcgttgcaa 642301 aaggccctgg ttcatacaca ggagtaagaa taggtgtgac gttggccaaa acacttgcct 642361 ggtctttaga cattccaata agtgctgtat caagtcttga gacgcttgcg gcaaatggcc 642421 ggcattttga cggtctgatc agcccaatct ttgatgctag acggggacag gtgtacacag 642481 gtctgtatca atataaaaat gggcttttag agcaagttgt tccagatcaa aatgtgatgc 642541 tggcagattg gctggagatg ctaaaagaaa aggaccgccc tgttttgttt ttaggccatg 642601 atacttctct tcacaagcag atgatcgagg atgtgcttgg aacaaaagga ttcattggaa 642661 ctgccgccca gcataacccg cgcccttcag aattggcttt tctcgggaag gaaaaggaag 642721 cagctgatgt tcatgggctt gtcccggatt acttgcggct ggcagaagct gaagcgaaat 642781 ggattgaaag tcaaaagtag ggtgatagga tgaaaacaaa agcagcggtc agaaatatgc 642841 ggcttgaaga tatagatcac gtatacgaaa tcgaagcatc ctcctttacg tctccttgga 642901 cgaaggattc gttttatcat gagctgctgg aaaatccgta tgctcattat ctcgtgattg 642961 aaaaggacgg ccatcttgct gggtattgcg ggatttggat tgtgatggac gatgcccaga 643021 ttacaaatat agcgataaaa ccagagtatc gcggccagtc tttaggagaa acgctttttc 643081 gctcagctgt tgaactgtgc aaagaaaaag acgcaaggcg gctttcgctt gaagtgaggg 643141 tttcgaatca tcctgctcaa ggcttatata agaaattcgg gatgcagccc ggcggaataa 643201 gaaagaacta ttatactgat aacggggaag atgcgttaat tatgtgggtg acgataaatg 643261 agtgagcaaa aagacatgta cgtattagga attgaaacaa gctgtgatga gactgctgca 643321 gctattgtga aaaacgggaa agagatcatt tcaaacgtag tagcctctca aattgaaagc 643381 cataagcgct tcggaggcgt tgttccggaa attgcttcaa gacatcatgt tgaacaaatc 643441 actttggtta tagaagaggc gtttcgcaaa gctggcatga cgtatagtga tattgatgcg 643501 attgcagtaa cagaaggtcc gggactggtg ggagcgcttc ttatcggagt gaatgccgct 643561 aaagcattga gctttgcata taacattccg ttagtaggcg ttcatcatat agccggtcat 643621 atatacgcga accgtcttgt agaagacatc gtgttcccgg cactggcatt ggtcgtttca 643681 ggaggccata cagaactggt ttatatgaag gaacatggat catttgaagt cattggggaa 643741 acccttgatg atgcggcagg agaagcctac gacaaagtgg cgcggacgat gggattgcca 643801 tatccgggtg gaccgcaaat tgacaagcta gctgaaaaag ggaatgacaa tattccgctt 643861 cctcgcgcat ggcttgaaga aggctcttac aacttcagct ttagcggatt gaagtctgcg 643921 gtgatcaata cgcttcataa tgcatcccaa aaagggcaag agattgctcc ggaagatttg 643981 tctgccagtt tccaaaatag tgtgatcgat gtcttggtaa ccaaaacggc gcgcgcggca 644041 aaggaatatg atgtcaaaca ggtcctttta gccggaggag tagctgcaaa cagaggcctc 644101 agagctgcat tagaaaagga atttgcccag catgaaggga ttacgcttgt cattcctcca 644161 ttagctttat gcacggataa tgctgcgatg attgctgctg ctggtacaat tgcttttgaa 644221 aaaggaattc gcggtgcata tgatatgaat ggccagcccg gccttgaatt gacttcttat 644281 caaagtctca cgagataata gcgtgagact ttttatctgt ttgttattaa cagacaattc 644341 acaatttatc cacatatctg tgagtaatta tagagatatt gatggataaa gggctgaggt 644401 cactgttaat aaagtggata aattcagaat attttgtgga tagtgtgtat aaagcgctta 644461 ctttgtttat ttattagggg atgttctgtg gataaaaagc acctctaaaa agaggtgctt 644521 gactttttta atcttcttct gtggatagtt cttcccattc ggacaaaaga gattccagct 644581 cctgattaag cttctcattg tctgcatgga tagcttgtac tttttcatga tcctgataga 644641 cttcagggtc acatagcaat tcatcattgc ggctgatgtt ctcctcaatg gtttgaacgg 644701 tggtttcaat ttcttcaatc cgacggagtc gttggcgctc tttctttttc cattcttttt 644761 cttcctcgta ggaacgtttg gagtcagact tcactgtagc tggcgtttta tcagtttcct 644821 cttgctgatt cattttctcc aattcaagct gctctgtttt tttctctgta taataatcgt 644881 aatctcccag atactcctct atatggcttg aagaaagctc caatactctt gtggcgattc 644941 tgttaataaa atatctgtca tgtgagacaa ataacagtgt gcctggataa tcaatcagcg 645001 cgttttcgag aacttctttg ctgtctaaat ccagatggtt cgtcggttca tcaaggatga 645061 gaaagttggc tttttgaagc atcagcttag ctagagccaa tcttgctttt tcgcctccgc 645121 tcagtgaatg aactggtttc agcacatcat ctccggagaa taagaaattt ccgagacacg 645181 ttctgatttc tttttctggg agcccggggt actcgtccca cagctcatca aggacacgtt 645241 tagaggaagt caactcagcc tgttcctggt cataatagcc gacactgaca tttgagccgt 645301 aagaaattgt tccctgatct ggttttaggg tgtctattaa tgttttcagc aatgtcgatt 645361 tacctattcc gttagggccg acaagcgcag cgctttctcc tcttgtgagc atgaatgaca 645421 cttctgttaa aagcggcggc tggttttcat agctgattgt gagatcctga acacgaagga 645481 cttcatttcc gctctgtttt gtaatatcaa aatgaaagtt tgcggatttt tcatcgccaa 645541 gcggttttga catgacatcc attcgctcaa gctgctttct gcggctttgc gcccttttgg 645601 tggtagaggc tctcgccaga tttcgatcta cgaagtcctg cagctttgca atctcgtcct 645661 gctgcttttc atacattttc agatcttttt catactgcgc ggctttttgg tcgagataag 645721 cgctgtagtt gccgtgatac tttttgcttt ctgctcttga tacctcgtat acctggttta 645781 ctactttgtc caaaaagtag cggtcatgcg aaacgatgag aatggcgcct gaatagcctt 645841 gtaaataatg ctcaagccag gtaagcgtat caatatccag atggtttgtc ggctcatcaa 645901 gaatgagcaa atcaggctgt gttaatagaa gcttacctaa agccagtctt gttttctggc 645961 ctccgctgag gctttgaacc tgtgtagaat cgtcaaaatg gctgaagccg agaccatgca 646021 gcacagatct aacatccgct tcatattgat aaccgccttt atctttgaat tcctgctgaa 646081 gacggtcgta ggttttcatg atgctttcta attcacccgg gtcagctgcc gccatttttt 646141 cttccatagc ccgcatttcc ttttccattg cttttaagtg gtcaaaaaca gtcagcagct 646201 cttcttttat ggtaagctta gaatccaagc cagtatgctg ggcgagatat cccattgtaa 646261 tatctttcgg tttaataatt tcgccctttt catacgaaag ctggcctgcg ataattttaa 646321 ggagcgtgga ttttccggcg ccatttcttc ctacaatggc gatgcgatca cgatttctga 646381 cttccagctt tatattgttt aaaatagtat cagcaccaaa tgatttggac agctgattaa 646441 cttgtaagat catcatatta tttcacctct gctataataa gttaagtgta gcttatgaac 646501 cagaagtcag caaacaatac attggccata taagacatag agaagaaaat agtgtatgat 646561 ctgtttaagg agcgttttaa tatgaatgga ttttctcatt ttaatgaaca gggcagagcc 646621 cagatggtgg atattagcga aaaatcttcg actgtccgta ctgcggcggc tgtttcaagc 646681 gtacacatga agaatgaagt gtacgagaaa atacaaagtc acgatatcgg caaaggagat 646741 gtactggctg tcgcacaggt ggcaggcatt atggccgcaa agcaaacgtc gaatatcatt 646801 ccgatgtgcc atccgctttc attgagcggg gtagatatat cgtttgactg gaaaataaaa 646861 gaagcagaag ttatacttca tataaaagca caggtcaaaa cgaaagggag tacaggtgtg 646921 gaaatggaag cgctcacttc tgcatcggtg tgcgctctta ccgtttacga tatgtgcaag 646981 gcccttgata agggaatggt catcggccct actttcttgc tggagaagac aggcgggaaa 647041 aacggtgact ttaaaagaga actatccgag tataatttgg aggaccaaaa atgaataagg 647101 atcaatcaaa aattccgcag gcgacggcga aacggctgcc gctttactat cgctttttaa 647161 agaatctgca tgcgtcagga aaacagcgtg tatcatccgc tgaactcagt gatgccgtaa 647221 aggttgattc tgccacgatt cggagggatt tttcctattt tggagctctt ggcaaaaaag 647281 gatacggata taatgtggat tatttgctgt cttttttccg gaaaacgctt gatcaggatg 647341 agatgacaga cgtcatcttg attggtgtcg ggaacttggg aacggcattt cttcactata 647401 atttcacaaa aaacaataac acaaaaattt ctatggcttt tgatataaat gagagtaaaa 647461 taggaactga ggtaggcggc gtgcccgtct ataaccttga tgaccttgaa caacacgtaa 647521 aagatgaatc agttgccatt cttacagtgc cagcagttgc cgctcaatcc attacagaca 647581 gattggtcgc attaggaatc aagggaatcc ttaattttac gccggcccgt ttgaatgtgc 647641 cggaacacat tcgaattcat catatagatt tagcagttga gcttcagtca ctggtttatt 647701 ttttgaagca ttattcagtt ttagaggaaa tcgaatagag ggaaaggagg agcccaaata 647761 tgccgatcgg tcctggaagc cttgctgtta tcgcaatcgt tgctctgatt atcttcggtc 647821 ccaaaaagct gcctgaattg gggaaagcag cgggagacac acttcgtgaa tttaaaaacg 647881 ctactaaagg attaacgagt gatgaagagg aaaaaaagaa agaagatcag taagttagga 647941 tgacacgaat gaaagtgaat caaatgtcgc tgctggagca tattgctgag cttcgaaaac 648001 ggttgctgat tgtagcgctg gcgtttgtcg ttttctttat tgctggattt tttttagcaa 648061 agccgattat tgtgtatctg caagaaacag atgaagcgaa gcagcttacg cttaacgcgt 648121 ttaacctgac agacccgctt tatgtgttta tgcaatttgc gtttatcatc ggcatagtct 648181 tgacctcgcc ggttattctt tatcagcttt gggcttttgt gagcccgggc ctctatgaga 648241 aagagcgcaa agtaacgctc agctacattc cggtctctat tttgctgttt ttagcgggct 648301 tatctttttc atattatatt ttatttcctt ttgttgttga ttttatgaag cggatttctc 648361 aggacttgaa tgtcaatcag gtgatcggaa ttaatgaata ttttcatttt cttctgcagc 648421 tgacgattcc gtttggactg ctgttccaaa tgccggtcat cctcatgttt ttgacaaggc 648481 tcggaattgt gacaccgatg ttcttggcga aaatcagaaa gtatgcgtat tttacgctgc 648541 tggtgatcgc agccctgatt acaccgcctg agcttctgtc ccatatgatg gtcacagtcc 648601 cgcttttgat tttatatgaa atcagtatcc ttatatcgaa ggccgcttat cggaaagcac 648661 agaaaagcag tgctgccgat cgggacgtgt cttctgggca ataataaaaa atccatttct 648721 catgcgagaa atggattttc tttatttttg gttctttttg attttaaatg aaaaggcgaa 648781 catcttaaaa gaaatgctga tgttgtaagc ggcgaacacc atcagcagga tggagtaaaa 648841 tgaccacatg ctgcctggcg agcttgcggc aagataagta aagatgcacc ctacggcaaa 648901 gtagatcatt ccccaaacta ccgggtttct cataaaaata atcctccaat aatcaattgc 648961 atttgtgtgc tctgctgttc aaggtaatta cgaacaggct caagctgcat gatgacgacg 649021 aatgtattca tcattaaatg ggcgaaaatc ggcacccata tccgttttgt tctcgcatat 649081 aaaaaggcaa aggtaaagcc cattgctgta tatagaagga gatgcttcaa atcagcgtga 649141 acaataccga agataaccga gctgatcagt cctgcgaaaa agaaattcgt tttttcgtac 649201 agcgcgccga aaatgatttt tctgaagatg atttcttcta atataggccc gacgatggaa 649261 gaaacgataa tcatgagcgg gactgcctga atgacatcca gaatcgcttg tgtattttct 649321 gattctcttc cgatgccaaa aacataatat tcaatagagc ctgctattcc ttgagagaaa 649381 agggcaatga aaaaaccggc tatcgcccaa aggatagaaa gtccgattga gtccttctgt 649441 ccgtttcgca gcgtttcttt cggaacggtt ctcagaatga gcagaacaac aacgagacag 649501 gcgataaagc tgataacgga ccataatcct tgtgcatgca gcatattttc atctgtaggc 649561 tgtcctccgg cataaccgaa tttaaataac aagggaatcg cgattaatgc ggaaaactgc 649621 atgatgatat atgtcaaaat aataaaccaa tactgttttc tcaaatggta tgtactcctt 649681 tgttaagtgg gtttcgttca tctacagcta ttgtaacata atcggtacgg gggtgaaaaa 649741 gctaacggaa aagggagcgg aaaagaatga tgtaagcgtg aaaaattttt tatcttatca 649801 cttgaaattg gaagggagat tctttattat aagaattgtg ttagcactct ttagtgctga 649861 gtgctaaaat tacatattca tactattgag gaggttattt cattgttaaa gccattaggt 649921 gatcgcgttg tcattgaact cgtagaatct gaagaaaaaa ctgccagcgg aattgtgttg 649981 ccggattctg caaaagaaaa accgcaagaa ggcaaaatcg tggcagctgg ttcaggtcgc 650041 gtgttagaaa gcggagagcg cgttgcttta gaagtaaaag agggcgaccg cattatcttc 650101 tcaaaatacg caggtactga agtgaaatac gaaggtactg aatacttaat cttacgtgaa 650161 agcgacattt tagctgttat cggctaattc ttaaataaac aatacttaaa acatttgagg 650221 aggtcttgta aacatggcaa aagaaattaa gtttagtgaa gaagctcgcc gcgcaatgct 650281 tcgcggtgtc gatgcacttg ctgatgctgt taaagtaact ttaggaccaa aaggacgcaa 650341 cgtggttcta gagaaaaaat tcggttctcc gttaatcaca aatgacggtg taacaatcgc 650401 taaagaaatc gagctagaag acgcgtttga aaacatgggt gctaagcttg ttgctgaagt 650461 agccagcaaa acaaacgacg ttgccggtga cggtacaaca actgcaacag ttcttgcgca 650521 agcaatgatc cgtgaaggcc ttaaaaacgt aacagcaggc gctaaccctg taggcgtgcg 650581 taaagggatg gaacaagctg tagcggttgc gatcgaaaac ttaaaagaaa tttctaagcc 650641 aatcgaaggc aaagagtcta tcgctcaggt tgctgcgatc tctgctgctg atgaggaagt 650701 cggaagcctt atcgctgaag caatggagcg cgtaggaaac gacggcgtta tcacaatcga 650761 agagtctaaa ggcttcacaa ctgagcttga agttgttgaa ggtatgcaat tcgaccgcgg 650821 atatgcgtct ccttacatgg taactgactc tgataagatg gaagcggttc ttgacaatcc 650881 ttacatctta atcacagaca aaaaaatcac aaacattcaa gaaatccttc ctgtgcttga 650941 gcaggttgtt cagcaaggca aaccattgct tctgatcgct gaggatgttg aaggcgaagc 651001 acttgctaca cttgttgtga acaaacttcg cggcacattc aacgcagtgg ctgttaaagc 651061 tcctggtttc ggtgatcgcc gtaaagcaat gcttgaagac atcgctgtcc ttactggcgg 651121 agaagtcatc acagaagatc ttggccttga cctgaaatct actcaaatcg ctcaattggg 651181 acgcgcttct aaagttgtcg ttactaaaga aaacacaaca atcgttgaag gcgctggcga 651241 aacagacaaa atttctgccc gtgtgactca aatccgcgct caagtggaag aaacaacttc 651301 tgaattcgac agagaaaaat tacaagagcg tcttgctaaa cttgctggcg gcgtagctgt 651361 catcaaagtc ggcgctgcga ctgaaactga gctgaaagag cgtaaacttc gcatcgaaga 651421 cgccttgaac tcaactcgcg cagctgttga agaaggcatc gtatccggtg gtggtacagc 651481 gcttgtaaac gtatataaca aagtcgctgc agttgaagct gaaggcgatg ctcaaacagg 651541 tatcaacatc gtgcttcgcg cgcttgaaga gccaatccgt caaatcgcac acaacgctgg 651601 ccttgaagga tctgtcatcg ttgagcgcct caaaaacgaa gaaatcggcg taggcttcaa 651661 cgctgcaact ggcgaatggg taaacatgat cgaaaaaggt atcgttgacc caacaaaagt 651721 tacacgctca gctcttcaaa acgctgcgtc tgtagctgca atgttcttaa caacagaagc 651781 tgttgtcgct gacaagccag aagaaaacgg tggcggcgca ggaatgcctg atatgggcgg 651841 catgggcggt atgggtggaa tgatgtaata aagggatatt aacccttata catcaatgtt 651901 ttaaccgtct taaaaaacta gacaaagcgt gaataaaaaa agagaaggtc tttcatcagt 651961 ttactaaact gttgggagac cttttctcca tattagcggt catatgagca taaatgtcca 652021 tcgtcgtatt tatgtccgaa tgaccaaatt gttgctggat ttctttaatg cctactcctg 652081 cctcaattag taaggaggta tgggtatgcc taaaagagtg gggggtgaca ttctttttat 652141 cccagctttt ttgagcagcc gtttaagtct agtctcaata acctttctta attgcggatg 652201 accatcctcc cgctcaaaaa taaatgatga gtcttgataa atcaatctat ttttaagctt 652261 aatttcattt tgataaattt tatttttttt tagtagattg acatcgtttc atcaattcga 652321 acgatatcaa cagatcctgt tgttttaggt gttagcaatt ggtatttttc aatttgattg 652381 ttaggggtgt atagggtctt tgtgacctgg cttatcattg aaatctgtcc attttaaagc 652441 aagaagttca ccaattctta ggtcggtcta ggcaagtacg gtaaagacca aatggtccat 652501 ttctagcccg tcagattgag cgagctttag aaaatgtgtc agcacctctt tttccaatgc 652561 tttgttgctt cttgggtaat tgaaaatccc cagttgggtt cattttaata atcccttgag 652621 ttttagcttt tcggaaaatc atacggccgc aggcatgaat acctcccaaa caattgtgac 652681 tgtattgctc gttcagttct aacgtgcggt cttcatacat ttttttgtgt tttgctaatc 652741 gggtattgac ccaatactgc gataaaatgc atcattttct tttcactggc ccgtacactg 652801 cttattttta ccccactccg gttgtaaatc ttaagccaac cttttgcaaa tgttttgaag 652861 ggcatatctg actccttaat aaaagtcccg ttgtcgtttt ggagttctac gtgacgggct 652921 gctactgggg cttctttctt tgttttaaat cttcctttgg atatttctag acgttttttg 652981 gttaaagggt caatgcctag tagatatgat aactccacgt cttaccgcat tgcttgagtt 653041 ttgccattta tttgtcccta actaattttt tttcatcaaa ttggtcttta agtgagttta 653101 ataatttttg tttctctcga ctggtcaata attgcccttc atatttcaaa agattggata 653161 aatttgagat ggaatcaatc ctgatggatt ctaaaagctt tgtaaatttc taattttatc 653221 ctggcctact gtgcaacaga ccttcttaat cgagcctaat tttccatcta tttgattggg 653281 gaacaaatgg ctttttaaca agaaagaagt ccaagaatac attgattggt ggtcaattga 653341 ggttaaaagg aaaaagaggg cctgatatat ctttcacttt cgcctaacta gcaaaattta 653401 ataaaacgat aagcgatgtg aggtgaaaat tatgctaagt gataataatt ttgtttccga 653461 aacactggag aatgtacagt atctattgcc aggtgcaaaa gtaatcaaat tgaggggata 653521 cagcagggcc cacaaagtat acaccattgc aaaatccccg gtagaaaagt ggaaggtcgc 653581 cgcaggttta tccggatcag agatagcaat tctgattaga aaaggtcatt ggattggtgc 653641 aagcattcca gctggcggaa ttgtcatcga tattgatgat tcaaaacagg gagagctagt 653701 gaaaggttta ctagatgcgc aaaactttca ttgtcattgt attaggaccc taatgggtgg 653761 cagtttattt ttaaggataa ccaacatggg gaaaagaaaa ttaaacaaat aaccaaattt 653821 tttactcaaa taggtatcat agtcgatgct gggatcgctg gggcaggcta tattgttttc 653881 ccaacaagta acactgagga cgatatatag taactaagag tcctaatgag ttagatgaaa 653941 tacctaatta tctgaggcct gtacggaatt ctgttaatgt aaaggacaac aacactggtg 654001 aaaaatatgt attccctgta ccaatcgaca gagttggtag cagaaatgat actttaaatt 654061 tgctacacat ttgaaagcct ggaaggtgga accatacgaa attagcaagg ccatggaatt 654121 gatttataaa taccttctgc tggataaaaa agatttctct ttggaggaat tttataaact 654181 caccatatat gctatcaaat ggaaactgga acaagctcag tttccattgt atttagaatc 654241 cacaaaaaaa tcgcatcaaa atgttattcc ccagccgttt aagataaaag gaaatgtctt 654301 atataaaacg gtaatcaaga atagcgggga ctttgaagaa tagctcatca tggcgtgtag 654361 gagtgattca cccttttaag aaactgtcta atatcgaaag aaacagtgtt cattatgaac 654421 tagcctcaaa cgataacgga cgcgaaaaaa aggatatagt tcctgctagt gttatatcac 654481 caagcgggag ttgcttttca ttggcggata atgggctagt tgagaaggaa gggcaaaaaa 654541 tgaagctgac agagagacaa cgacgctttt gtgatttctt tacagaaact agaaatacaa 654601 cagaggctac gcgtctagcc ggaaacaaag ggaaaaatct caacagagta gcttctcaaa 654661 acttgtcaaa actagacatt caaactatat agagcaaaga aataatcaac tagaagcgga 654721 gcgcatagca aacattattg aggtaaaaat gttttggaca attattatac gcgatggaat 654781 agttcggtta aagagcgact aaaggcgtct gagtatatta ctaaaacaaa tgcggccttc 654841 aaggaataga ttgaacatac tggtgaaatt aaaacaggga atgaggaaga agctaaattc 654901 gaatgagagt gatctaaggc ttctagaatt gtatatggag gtgtggtaac gtgagcaagc 654961 ttatatagaa ggattaagtg atcaagttta gtgtaatact aggaatgata aggtgttcat 655021 taacgcacat tacaactaaa aataccgtaa atgccctcaa gaggatgata tatccaaagc 655081 aaaaaccttc attctttcat gaatttaaag tattatataa gctactgaaa aagttttgta 655141 taaaaggtat aatgataaag aacattcgtt cttgtatggg gtactttctc tgagaatgaa 655201 aataatgtct tagggtgata taatgacaaa ttttatttta aatgaaaata aacagttatc 655261 attggcaatt gaagatgaga acatagaaaa tttttatata gatggtacag atttagtccg 655321 aaagataatc cgtagatcag gttcaggagt tacatcacgg gttccggtcc ttagcaccca 655381 agatttagaa aacaagaacc ttcatgaatt atacgatgaa tcttggctcc gtatgaaaaa 655441 cagacccaat actgagctca ctactgagag tataaatatt gcggatttat ttagtggatg 655501 tggaggtcta tccttagggg tttgggaggc atgccgtgcc ctggggataa atccaagatt 655561 ttcgtttgct tgtgatctta acgaagctgc cttatctgtg tacgaaaaaa acttttctcc 655621 cgattttagc ttgaatgaat ccatcgaaaa acatattaat ggcgagttag gtgctccatt 655681 aactgttgaa gagcaaagaa taaaagataa ggtgaaaaaa atagatttca ttctagcagg 655741 tcctccttgc caagggcatt ctgatcttaa taaccatact agacgaaaag accctagaaa 655801 cgctttacta atgagagtaa gtagagttat agagttgttc caaccttctt cagtattagt 655861 ggagaatgta ccaggaatta ttcatgataa atctggttct tttaaagaat ttaagaatca 655921 tttaaagaca caaggttatt acttcgatga aatcgtacta aatgctgaaa aactaggtgt 655981 ttcacaagca cgtcgtagat attttatttt tgcttcaaaa actcctgtat cttccttaaa 656041 tcaaataaat gaattttatt caaccaatag taggccaatt agttgggcaa tatcagattt 656101 agtagaaaat gtaggtgatg atatattcaa cactgcttcc gagcattcat tggaaaacaa 656161 aaggagaata gaatatcttt ttgaaaataa cttgtttgaa ttacctaatt cagaaagacc 656221 ggattgtcat cggctaaaac cacattcata caaatctgtg tatggcagaa tgtattggga 656281 tagacctgct cccactataa ccagagggtt tggatcaaca ggtcaaggga gatttgttca 656341 ttctttgtta aagagaacga taactcccca tgaagcagct aggattcagt tcttcccgga 656401 cttttttaac tttggtgacc ttcggaggag acagtatcaa gacgttatcg gtaatgctgt 656461 gccttccaaa ctatcctatt tattagcatt acatcaatta agataaaaag atttgaggtt 656521 gatatctttg aaagttgtta gtttattctc cggcataggc ggaatagagc ttggccttca 656581 tcagtcagga catacaacag aaatattttg tgaggttgat cctttggcaa aagctgtttt 656641 atcaaaaaac ttccctggcg ttaagataga agatgatatt aatgaaatta gagagttacc 656701 aagctgtgat ttagttgcgg cagggtttcc atgccaagat ttaagtcaag ctggaggtaa 656761 agaagggatt gacggatcac gctccggttt agttaagaaa ctatttgaac ttatagaaaa 656821 gaaagaacat gcaaatcgcc ctccatggat actaattgaa aatgtcccat atatgttaag 656881 gttaaaccgt ggtaaagcta tgtcatattt aacatctgtc ctttctgaat taggttatac 656941 ttgggcatat cgaactgttg atgctcgttg ttttggttta ccgcaacgaa gacatagagt 657001 tattttgtta gcctctttat ttgaagatcc aaaagatgtg attttttcac aggatcattc 657061 agaaccagat ttagatggaa agccttctgt tgtggatcat tccaactatt atggttttta 657121 ttggacggaa gggttaagag gtgtcggctg ggcacgtgaa gcagttccac ctataaaatg 657181 cggatcgtct gtaggtatag cctctccacc tgcagtttgg tctccttacg aggatatagt 657241 agggaccatt aatataaggg atgctgagcg cctacaagga ttcccggaag attggacaaa 657301 tatcactact gaaacaggta aggatataaa agaaggtgcc agatggagat tggtgggaaa 657361 tgctgtttcg gtaagggttt ctaaatggat tggtgaaaac ttaagtcagc caaaagggtc 657421 gatatcagat tttgaaggtg aattagtgac caagacttgg ccaagtgcag catgggggta 657481 cggagataaa aagtataaag ttcccgtatc aaaatgggtt gcaaacacag aacaaatagc 657541 tatttcagag tttttaaatc atccattaaa acctttatct gctagggcat taaacggttt 657601 tttaggtaga gcagccaggt gtacaaatgt aaattattcg gatgaattta ttaactcgtt 657661 agaacgttgt aaggataggc aacttcaaaa ggtttaactt ttcacattaa agagagcata 657721 ctaaaaagta tcggagctgg ataaaaccag ctccgttttt tatctttaat tttttttgca 657781 ttattccatc ttttattcga ccagttccat aaactccttt tcaattcttt gggggtttcg 657841 ggtctcggca agactttcat ctaccctgaa gtagaatttg atttttggtt ctgttcctga 657901 aagtcgcagg cacatccagg gatccgactt caagaaaaca tttaagaaca tttgactgtg 657961 gaaggcccat gagttcctca gggccttcca cagtctctcg attccggtca agtaatcctc 658021 aacagtggta accttgacgg aaccaaagct ggccaaattc agaacggaag gcagcgaggg 658081 tctgctgaat cagttctgcc ccttcttttc cctttagtgt taatgagcgc aggccttcct 658141 gaaagtagcc atattcttca atactaagga gagcttcgta tagtgaaatc cttttttctt 658201 atagtaagca catacctcaa ctgcaaggac atccgtctga acagcatcct tgtctcggac 658261 aaagtcgcca atcagatagc catagctctc ttcgtaccca aagaggaaat tatgttctcc 658321 tgtcttgtag tagccattaa tctttctggc aatgaactta aatcccgtta atacaccgat 658381 tgtttcgact ctgaaagagg ttgcaacttc cctcccaagc tccgaggtaa caatcgtttt 658441 aagaacgatc ccattagatg gaagtgttcc tttctttttt atttgggtta agatatagtg 658501 gagcagaagt ggctcggttt gatttccggt taaaaccgta tactcaccat tttcattttt 658561 aacagcaatt ccaagcctgt ctgcatcggg atctgttgca attaaatatc ggcgtcaatt 658621 tgctgccttc cctgatggcc agctcaaacg cggcatgttc ttcagcattt ggactggtga 658681 tagtggaaaa cagagggcag gctgctcctg ttcttttccc accgctacat gcttgtagtt 658741 cattgccgcc aaggccattg cagtagattt gctgtaccat gaagcggcgt aaatacaacc 658801 ttgatgtctg tttcatctta aatatttgag ttttctgaaa tagttcaagg tatgccttgt 658861 ccacctctgc gctatatttt gatcaggccc tttgctagga ggaagctggc cgccatctgg 658921 cccataaact ttatatccat tgtattcagg cgggttatgg ctcgcagtca caacaatacc 658981 ggcaaaacca tgaaggtgac gtactgcaaa cttaacacgg ttgtaggcct taatgactcg 659041 aaaacgtatg cgctggatgc cagtgtcctg gcggcttcca ttataaaagc cgccaaccca 659101 gcagaaactt tccttaacgt atagatgtca tccggtttgt tccagctcca atttccccgc 659161 gcatgcctcc tgttccatat cccaaattcc ttataaaaag catcttccag gtctttctca 659221 ttccttcctg atttacccaa ccccgatttt agctcggtgc aagttgacta aactgtagcc 659281 atttttctgt tttgtttttc cagcctatga ttgacctaca ataaaataac attattgttc 659341 attataatat agtctagagg ttttcgaacg acgactttct gacataaatc gagtgctctt 659401 gtctgattat gtctagttat agttggtttt ttttattttg tctctaaatt tgatgagatc 659461 atggtggcga ggaatttctt tttcgacagc cccaatcagt accaattcga tatttgaatt 659521 ggtctctcaa acaattccat cctctttatt tattatgata caattatatt aattagaaaa 659581 tacatacata ttagcttgtg tgattttatg ggggtaaaat caatgacttt tataaaaaga 659641 ttagaggacg cttatgaaac tctattaggg aattaccctg ccggagtatc tagtaccagt 659701 actagtaagt ataacgaaat acgaaagatt gtttcagaag ccttcttgat cggtgaaaat 659761 gaagtgtatg taacgggaac atcaagaagg attagcaatt tggacactcg gtttgctcaa 659821 ggaaatcaac ggaataaaca tacccggatg gcagttgctt ttatttctat accttctgtg 659881 gacgattcgg aattagatga actaattata agaacgagaa atagtgcaat tacaacctca 659941 tctaaattct gtaacgggga agaaaggggc acgatttttg acggaatatt acttttttta 660001 gtatttgagg gtgaaaccaa agtgtatccg ctagcattct tagttttcga gaacgatttt 660061 gaattaaagg aaaaggctga ggaattgatt ccaggaattg aactcaaaga atacccgcga 660121 gctaatcaat ccccagccca ggaaaataac aaaagcgcta aaaatgaaga tgaggaaagt 660181 gcaaagagct atgtagtctt ccttgatatt gaggaagatg gttctattgt ggaatttgta 660241 gaagataaag acaaaaccta tagaattggt gatatgattt ggacggcttc acatactaat 660301 ggttcatcag ctatcacacg cagactggaa gtaattgaag tcgttgaaaa tcttgtggtg 660361 tgtaagataa aacataaata taatgaacct gttgataaga attcactgct taagtttgta 660421 aatattgaac aagatttgat ttcatttcta gacttacatc caaatgtcca aaatggaagt 660481 gagggatttg tatctgggga cattgttgat gagaacgcta ctacatcatc ggatgactta 660541 ccggaagact ttgaaaataa ctaagcgata aactttaaat aggggaaatg aactgatgga 660601 aatatccaaa caaacttcag atttattatt gagcctagaa aagaaaaaag gcactttacc 660661 aaaattcagc gttttacgca gtattcctag gaataggatt atttatggtg caccaggaac 660721 agggaagagt aattatctag aaagggaagt gggaaagatc tttggtgata atccatatgt 660781 attcacccga gttacttttt tccctggtta tacatatgga caatttatag gtgcttataa 660841 accggttcct atatataaaa aattaagcgg tgaggaagag atatttagtt caaactttag 660901 ggataagatg gaaaactttg agccaatgat tgattatcaa tttgttcctg gcccatttat 660961 cgatgtatta attaaagctc tgaaaaatag atacactaat tttatattaa ttatcgaaga 661021 aattaatcgt gccaatgcag caagtgtttt tggtgatatt tttcaattat tagacagaaa 661081 taaaaacggt gaaagtgatt atcctgttac attcgggccg gacattatga attatttagc 661141 gagaaacgga attaaagatg aaatgattaa gctaccatcc aatttcttta tttgggcaac 661201 tatgaataat gcggatcagg gtgttttacc gctcgatacc gcttttaaga gaaggtggtc 661261 atttgaatat ttagagttgg aaaagtatag aaaggcagtg gactcttgga agctgagcct 661321 cagatataaa ggtcataata aagtaattat gtggaatgat ttccgagaca ttattaataa 661381 gcgtcttaaa ggaaaagtac cagaggataa gctgcttgga ccttttttcc tgaaagaaag 661441 tgaactgtgg aatcagaatg tatttaaaaa taaactgctt tattatttga aggaagatgt 661501 tttcaagcat aatccaacga ttgatttttt aaatgctagt actttctctg agctaattga 661561 aaaatatgat ggctcggata acatttttac ttttgacata gatgattcgt cttttgtgag 661621 tgattaacta tggataagtc aagtaagttc ttctttgaag atcaaaaata caataaagaa 661681 aggattgtac gtgtactcgg tggtaattta gctttactca aaagtaaagg tatattatat 661741 gaagattcta gtggggattt aatatttaac tatgtaggtg ttatatctaa tgggcgcaat 661801 gtaatattca ttttgcctaa atactgtaac aggcacttag atgaacattc aaagcggact 661861 ttgtttaata agttgctgaa gatttttaaa aaatattcag gtttaaataa aagccgggaa 661921 tctgattatt tcgtatcgga gctagatagt gatgaagtct ccgactttat gatagcagat 661981 tatttgctta atgatttctc attgaatggg tattatcaaa aaaaatttac tgaatatgaa 662041 attgatggag aaggaattat agattggagt aagacagtta atgaaattac cccagtattc 662101 tcaaagggag ttccatatta tttcagtact tataatgaag tggtacaaaa agacgagtat 662161 cacttgatag ttaaaattca taaatgggct ttaagtaaat attttaatga tttcggagtc 662221 attttaggtt ttacgggact agaatttgat aaatcctgtg atggtatgaa aattttggac 662281 tacgctgatt tttttggctc agtaataaat aaagaaatcg tgaacacata tgttgatcgt 662341 gacgttaaat tgttaaaggc attgaaaacc gcaattgata gggaagagaa tcagttttct 662401 aaacgaccca ctctttctct gtatggaaca aaatactttc acagagtatg ggaggaagta 662461 tgtaagaccg tattttccca tgttaatgaa tacgtaaaaa agatatcaag gccaaattgg 662521 attaacttta cggatataga ggttaataaa gagaaaaaaa cactagaacc cgatattatt 662581 aaggctttcg aataccgttc aaaagaatac tttttaatat tagatgctaa atattataat 662641 ataaattttg acggaaaaaa gctggagggg aatcctgggg ttgaagatat aactaagcag 662701 ctgttatatg ataaggcact tgaaaaactg tccagaggta aaacaaaaca taatgctttt 662761 ctgtttcctt cctctaattc aaccaatacc tttaaagtat ttggttctgt tgattttgat 662821 tttcttgata tagccgctgt aactcttgtt tatatttctg ctgaacaagt ttataactta 662881 tatcttgaaa ataaaacatt ttccactgat gacttattta aatttgtaag tgaaattaat 662941 aagtcaaaaa aacgacatag cgttataact tcaacattgt atggtaatat gtttttgttt 663001 acaaaaagat taagtgataa aaattagttc tagaaggtta aaagccgata acataatact 663061 tgtcctcggt tttgtcctcc tatagtttta aaaatattta tcagcattaa atgttaagtc 663121 taaaaaacag tattttgagc tggttttttt aatactattt tcaactgtta ttagtcggaa 663181 tgaatgggtt gcatgatgta aaaccgacaa aaaactcttg ataaacaggg gtttgtcggc 663241 aacggacttt tatttttgat gcccttttgg ccatttgcaa attttcaagg cttctcatga 663301 gttcaccgaa cttgtgagaa gcttcttttt tgatgtataa ataaacatgt gtagtgtgta 663361 caagcttaca tggcatttca tttatggacc gcttctctct ctattgcaga caggataccc 663421 tattggtata ctctcatacg acacaaaaaa gacccagtta tctaaataag tagtgccacc 663481 cactcttaga ctgtttcccc tagaaaagca ctgtcaaaga ggaatcctgt taaatcttgt 663541 gcttctttgc ttttttagct aaaagacgat gttttccttg caataaggaa ctcgtctttt 663601 atgttaaata taaagagcga cagaataatg acatctgatc cccaaaaatt cactgtcgat 663661 ggagttagat tcttccaaca gtaccttaat aaaatccgtc ccgacgctat ggagatagac 663721 aacctaatta tcaactctga tattatcaag gaggacttaa tagtgcatgt ctcaaaaatg 663781 atagatcgtt tggctttata tgatttacac agaaaaagaa gcatagataa acatttttct 663841 gctgctttta cagtcgatat caatgataga gaggaatttt acagtgcaaa tatagctgat 663901 gtttcaattg atttgaatga atctagtggt gtttaattga atctcatatt cttcagaaga 663961 accattcaat acttcttgaa caatatttaa agtattcatc agcttcctct actgaaacaa 664021 tatcttcaat gaaatcggaa aagtattcta gttctgttct tgttggaaga actattctta 664081 agtatcctaa agggtctctt ttaaatgaat ataccatgat aaatcagtct ttcctttctg 664141 tttattctta gttaatattg atcgtacaat tgagtcgaca agacaggcta ttgtagattt 664201 acgggcgttc attcactgga taaaagcaaa taaaaaaggg cctgttatca tagtcggagt 664261 aagccttggg ggatgggtta ctaatctaat tgctaccctg gaatcgaaaa ttgatgtagt 664321 ggtatctatc ttttatgcca atcgcctttc ttattcgata tggaacacga tcccaggtaa 664381 atacataaga gaagaattag aacaaaatgg tgtgacctat aatgagttaa taaaatattg 664441 ggatatcaca gatcctagtc aagccttgcc gaaagttaat aaagataacg tactgctgat 664501 ttctgctaaa catgatcaat atattgactt gaaagatgca gattatttat gggaaagttg 664561 ggggagacct acaagatatg tctacaattg tggtcattcc ggtattgttc tttgtcgcaa 664621 aaagctggca aatgatacgc tttcctttat acgagaaaaa ctggtttgat acatttgtag 664681 actttaataa gaaacgaaag gccaactgcg acttcagttg gcctttccta tttataataa 664741 agaaattgag tgagattgct gacagaacta cgtactactc gttttcttta gttgcccttg 664801 ctaatcgttc aacctctccc cgaatcccaa tcgcaggctc ccacgaatca atcaaacgaa 664861 tcgccttctg attagattcc accgctttcg ttttctctcc tttacgatac aacagctgcg 664921 ccattccgta gtgatagtag atcagttcaa cttgattggc gttatgtttg tcatagagca 664981 tttgctcaaa ggcttcttcc gctttttcaa actgatcaca tttcacgtaa gcgacaccca 665041 gattgaaata ggcttctatc gttttttcgc cgccgtatgt ggagctgatt tcatttgccg 665101 cttcgtataa ttgaatggct tctacatgat aacctctcgc aaagcttaag tcaccgcgaa 665161 ccaatagaac tctgtgttga atggtagggg aaatcggttg attttcgatt tcgtttaaaa 665221 ttgtctctgc tttttcctgt tgcccgtctt ttaaaaacag ccttgctttg agtgcatgtc 665281 cccaaacctt tagatcatag gcatcgtgag cgtctgattg ttcaagaatc ttcagcccgg 665341 cttctatttg ctgaagcgct ccgtctaaat cattgacttc catcaatgcc cagcctgagg 665401 tgtcgattcg gaagtacgct tctcgtgtgt gttggcctaa gtgatgggcg gcgtcggccg 665461 ctttgcgtcc gtattcgatt cgcaggggca ggttgattct gcttagaaaa tggctaatgc 665521 gggtgatgag ttcgattagg atttcttttt gttcagtttc acttgcccat tggatgacct 665581 ttaagatgtt tggccattct tgtttcattt gatctaagtt ccgtcccagc aggtagctcc 665641 aatagataga gttgggctgt tcccgcttta aatgggtttc ggcataatca atataatagt 665701 gcgcccagcg attgcgggct tctttttcat attcgtgctg ttcggacaag tgctgttctc 665761 cgtaagcgac aacggtttgg tgcgctaagt attgtgtcct gccttggctt cgttccggct 665821 gaatcagcgc atatgaccgc atttgttcca tagcgtaatg aaaacggcgg gcgtctaatc 665881 cggctgctgc cgccaggctt ttttcatcag gcggcttgct gaaaaagcaa agcgtctgcc 665941 agagctttcg cgtatcttca ttgcatctat cccaggtgcg gccaaagagg aattcaaaca 666001 attccagcag tgagtagcct gcttttccaa gctcatgaat cagctgctga gcggggatgt 666061 catcgtctga catataggca atgctgagtg ccatggcttt cgggtttccg gcagtcgctg 666121 aaatgaattc gtttttcagg tcagatgata gatgtaacag ctgctccagc ttttcccgtt 666181 tacgtgggag gttgcatgtt tgtaagcagt gatgcacttc ttgttgaaaa aattcgtggg 666241 catctgtttg gtcaagaccg cttagctgaa tggctgtcat ttctccgaag ctttcccgat 666301 aagtttgctt tacgttttcc cgcgctgtaa ggagaacttt tacgccttgc ggaaggctgg 666361 tgataaattc atgaatgtca cgttctgcag tatcaatgct gtcaacgatc agcaggatcg 666421 gtttttctct agtgtaattg gctaacgcat tgcggacgac aaaccgtttt acattgattg 666481 atttatcgat ttgttctttg cgtccgagct gataggcgat cgtatttaaa aaatcgctaa 666541 agcttaatcc tttccaatca gcgctgaccc agatgatgct gttgaatgcc ggccaaactg 666601 aagtatcgtc gacacaggaa taggcggctt caagagcaat tgtggttttt cccatgccgg 666661 cccagccggt gattaaacag actggtgatg gagaaagcat ccattgccgt atcgcttcca 666721 tatcaaagct gcgtccgata aagcgtccgg accagcgtga gggtaaatta tgcgtgatgg 666781 gctgttctgt aagcgcattc gtttcttggc cgggtctgtc atgaaacagc cgttttacta 666841 cattttcaat ttcgccttca ctcggagccc cgaataatcc gtcttttcgc agtattttcg 666901 cttttttcaa acaggatgct gcccatacag gcaatgcggg tttgatgact gggatagtgg 666961 tggcttccag caagtcggtc aaccactcga tatccaagtc ggtcttttcg agaatgatcc 667021 agatcattcc gaacagtttt ccgtcgtcga ttcttccggg aatgtagttt gcccccatct 667081 gtccgatcca gcttttgatc gtgtttgggg agactcccag ctggagtgcg attttatcta 667141 tgtaagactg tcctgttttt tcattctttt tccttctgac tttataatca ggatgaagtt 667201 ttagcgtttt gacgccaggt gccagcattt gtgcaaattg ttttcggttt tcaagttcag 667261 ccataagcct gcacctccta ttagtactat tttatcaatc cagcgttttt tgtatatgaa 667321 aaaataaaag tacagtgccg ctgtcctttt atacagcagg aaaggctgtt gaacgtgtta 667381 aaaagcagat aaaatggggg cagtaacaga gaaaacaaaa atgtatgcac ttacatttta 667441 ttttctaaag aaaggaactt gccaaatgac tcacacagta cctcaaaaca tgaaagcggc 667501 tgttatgcac aacacaagag agatcaaaat tgaaacattg cctgtgcctg atatcaatca 667561 tgatgaagtg ttgattaagg tgatggctgt cggaatttgc ggatctgatc tgcattacta 667621 tacaaatggc cgaataggca actatgttgt ggaaaaacca tttatccttg ggcatgaatg 667681 tgcgggtgaa attgccgctg tcggatcatc tgtcgatcaa ttcaaggtgg gagaccgcgt 667741 cgctgtagag ccgggtgtta cgtgcggacg ctgtgaggcg tgcaaagaag gacgctataa 667801 tctttgcccg gatgtacagt ttttggctac accgccggta gacggtgcgt ttgtccaata 667861 tattaaaatg cgtcaggact ttgttttttt aatcccagac tcactttctt atgaagaagc 667921 tgctttgatc gagccgtttt ctgtcggtat ccatgcggcg gccagaacga agctacagcc 667981 cggatcaacg attgcgatta tggggatggg ccctgttggg ttaatggctg ttgccgcagc 668041 taaagcattt ggggcaggca caatcattgt caccgactta gagccgctgc ggttagaagc 668101 tgcgaaaaaa atgggagcga ctcacattat taatatacgt gaacaggatg cacttgaaga 668161 gattaaaacg atcacgaatg atagaggcgt tgatgttgct tgggaaacag cagggaatcc 668221 agcggcattg caatccgcac tggcttctgt gcgccggggc ggaaaattgg cgattgtcgg 668281 tttgccttca cagaacgaga ttccgctcaa cgtgccgttt attgcggata atgagattga 668341 tatttacggg atcttccgtt atgccaatac gtatccaaag ggaatcgaat ttcttgcttc 668401 aggcattgtg gacacgaagc atctagtaac ggaccaatat tcgctggagc agacgcaaga 668461 tgcgatggag cgggcgcttc aatttaagaa tgaatgttta aaagtgatgg tgtatccaaa 668521 tcgctgagtg aacagggagg atcttcgtat tctccctctt gtttactgga aatgaaaacg 668581 gattcttggg gtgggaaatg atgattggaa cagaaaaagt aacggcattg aaggcgaagc 668641 atcagtcaaa atccagcacc ggcctgtcct ggtttgaacg aatcggttat ggattcggcg 668701 atatgtcgta taatattatc tttcagtttg taaacgcata cttattattt tattatacag 668761 acgtcggcgg cattcagcct gcggtaatcg caactttgtt tcttgttgtg cgtgtgctgg 668821 atgctatttt tgacccgatc atgggattga ttttagataa aacgaataca aggtggggaa 668881 aagcaaggcc atatttgctg tgggtggcat ttccttttgc gctattcaca ttcttatgtt 668941 tcacgacgcc tcatttcggt gagaccggaa atatggtata tgcgtatgtc acttatattc 669001 tgcttgggat gtcctttagt atgcaaacga tcccggtgaa cagcttaacg gggcggatga 669061 cgaattcggt ggaggaacga acggttctga ccacaacccg gatgattttg gtgtatatcg 669121 gcattctttt atccatttcc tgtgcgacac cgcttgcaac tgctatcgga ggagaggatc 669181 aggcgtttgg atttcagatg acggcgctca tctatgcggc tgtcagcatc gttttgaatc 669241 tatttagttt ctttactgta cgggagcgga ttcagcctaa aaagagaaaa aaacaaggga 669301 tcaaaaagac gttatccgtt ttattcaaaa acaaaccctt gctcatgtta atttcatcat 669361 ttttggcttt tgcgatcggg tttaatatta agctcagcac gatggtgtat tattttacgt 669421 ataacgtaaa ccataaagag ttcgtgttta tgggcaccgt tttatttttc ggggcagcgc 669481 tgatcagcaa tttgtttatt cctttctttt ctgagaagtg gggcagaaaa caagtcatga 669541 ttatcacggc agctctatcg cttatttctt atgccggcct gcattttacg ccgtattctt 669601 caattccact cattttcatt tggcttttcg cttcgggatt tttcacaacg cctttaaata 669661 cgcttgcttg gggaatggtt gcggattgcg tcgattatgc ggaatggaaa accggaattc 669721 gcgcggatgg tgttgtgatt tcgagcatga gctttattaa taagctgggt gttgcgttag 669781 ccgggtcatt ttcggccatt tatttaggaa tcgccgggta tgtggcgaat acagaccaga 669841 cagttgcgtc gttgaatgcg attaaaaata tgaatgcttt gattccggga tttttcattt 669901 tgctttctat tattcttatc gccttctatc ctttaacgga aaaaagatat aaacacatca 669961 tctctgagct ggagcaaagg tctgcgagat aaatagatgt aaaattttta atattcaatg 670021 ttgtatttat ggcaaaaagt aatatactga gactgtaatc tagactttat aaatgagtgt 670081 gataatatgc gtagtcattc tgtagtttgt attggggaat tgttgattga tttcttttgt 670141 accgatgttg acgttgattt aatggaaggg cgccaattcc tgaaaagtgc cggcggggca 670201 ccggcgaatg tgtcggcagc gattgccaag ctgggcggag acgccgcttt cagcggaaaa 670261 gtaggaaagg atccgtttgg gtattttctg aagcgaacat tggacgctgt acatgtcgat 670321 acctctatgc tggtgatgga tgagaaagcg cctacaacgc ttgcttttgt ttcattaaaa 670381 caaaatggag agcgtgactt tgtttttaat agaggcgcgg acgctttgtt tacgctggag 670441 gacattgacc aggaaaaact aaacgaagcg aaaatccttc atttcggctc tgcgacggca 670501 ctgttatcgg atccgttttg ctcagcctat ttacggttga tgtcgattgc gaaagacaat 670561 ggacagttta tttcgtttga ccctaactac cgtgaagatt tatggagggg aagagtctca 670621 gagtttgtaa gtgttgcgaa aaaagcgatc gctgtaagtg attttgtgaa agtcagtgac 670681 gaggaacttg agattatcag cggtgtgaag gatcatgaaa agggagttgc gatccttcat 670741 gagatcggag ccaacattgt cgctgtgaca cttgggaaaa gcggaacgct tctttccaat 670801 ggaaaagacc gtgaaatcat tccaagcatt ccggtgacat caattgactc aacaggggcg 670861 ggagatgctt ttgtcggtgc ggctttatat caattggcaa acacggatca gattcaatct 670921 gtagatgctg attttgtgaa actgcgtgag attgtggcgt ttgccaataa ggtcggagct 670981 cttgtgtgca ctaaaattgg agcgattgat gcactgccga gtttggatga gattggagtt 671041 tctttgtaaa tcattgaaga tgtttcttga aagtctttgg acttttgggg gcatcttttt 671101 ttattgctta catttttgtt caggtaaaaa gttgtatatt ttttgtttga aatgtcattt 671161 tttattaaaa aagtgaaact tttaacgata ataaatagta tatgtaacaa gggttaccga 671221 attagcttta ggaggaacga tataatgagt ataattggaa gatttaaaga tattatgtct 671281 gcgaatatca atgctttatt ggacaaggct gaaaatccgg agaaaatggt agatcaatat 671341 ttaagaaata tgaatagcga tttggctaag gttaaggcag aaacagcagc tgttatggct 671401 gaggagcaga gagcaaaaag agaatatcac gaatgccagg cggatatgga aaagatggaa 671461 agctatgcaa tgaaggcgct gcaagccggg aatgagagcg atgcgagaaa atttcttgaa 671521 agaaaaacat ctttggagtc aaagctttct gagctgcagg cggcgaatca aattgctgca 671581 accaatgccg cacagatgag aaagatgcat gacaaattgg tatctgacat tggagagctg 671641 gaagcacgca aaaatatgat caaggcgaag tgggcagtag cgaaaacgca agaaagaatg 671701 aacaaactgg gcgcttctgt ttcaagtaca agccaatcaa tgtctgcatt cggccgaatg 671761 gaggacaaag taaataaggc acttgatcag gccaatgcaa tggctgaact gaacagcgct 671821 ccgcaggatg atatggctga tctgtctgca aagtatgaca ctggcggttc aagccaggtt 671881 gatgatgaac ttgcggcgtt aaaagcgaaa atgatgctcg ataagtaata cataggaggc 671941 cgcagctttc ggctgcggcg tcattttatc ataaaatgtg agagggaacg gtaatgataa 672001 tatcttataa gtgtccgaac tgcggcagtg atatggcatt tgacagtgaa accggctcgt 672061 tatcctgcag cagctgcgga agacaggaca atattgaaag ccttccgaaa gaaaacattg 672121 cggcacggtt ttctgatgat gaagcaaaag aatatcaatg taaaaactgc ggtgccgttt 672181 tgatcacgga agctgaaacg acagcaacga cgtgcagctt ctgcggaggt gctgcaatac 672241 ttgccgatcg tttatcagga catttggcgc cggcgaaggt cattccattt acaatcagca 672301 agcaagaagc ggagcaggca tttcgaaagt ggtgcaaaaa aggccttctg acaccaagag 672361 gtttcatgtc tgctgatcgt atcaaaagca tcaccggcat gtatattcca ttttggatgt 672421 ttgatttaaa tagtgaagta caggtgagag caaactgtac cagagtccat caatatgaag 672481 aaggggatta tatttgcacg gaaacagagc actttgaagc gtttcgtgat atcaatctcg 672541 attatttgaa aatccctgtc gatgcctctg aaaaaatgaa agacgaatta atggacaaat 672601 tggagcctta ttcatacgaa gagctgaagg actttcaaac ggcatatttg gccggttata 672661 ttgcggaaaa gtacaattat accgatgagg agctttttcc gagggcaaaa gagaaaatca 672721 gcagttatat agattcatac atccattcta ctttttccgg atatacgtca gtcaatgtga 672781 gggacaaaca tattcacacg aaaaacgtga acagctttta cgttttgctt cctgtttgga 672841 tggtcagtta cgattatgaa agagcggagc atatctttgc gatgaacggg caaacaggaa 672901 aggtcgttgg aaagccgccg atcagtcgag gaaaagtggc tgcatggttt agcggaatag 672961 caggcgggac atttcttgcg ttgaagctcg tctcattgat gatgggaggc ggattttgat 673021 gcgtggattt tttgggaaag cgatctttgt tgtgctggct gttttcatca tgatgccttt 673081 actgggtatc gaagcggtaa gagcctctga attgcagcag catgtgtacg atcgcgctca 673141 tctattgtca aaagcggaga tcggaaaact tgaatctctc tcggcaaagc tgggtgcaaa 673201 gagggacact gatttcatca ttattacgac caaaagcaca aacggtgaag atattgcaga 673261 ctataccggc gatttttatg atcgttacgg aaaaggcagt acagccattc tgacgattga 673321 tatgacaaac agagaagtgt ttatcgcagg ctttaaaaaa gccgaacagt atttggacaa 673381 cagcaggctc aatagcatca gaaatacgat ttcatctgat ttatccaatg aaaattattt 673441 tgaagctttt gagacatata ttcagctttc ctataaagat atgggcataa aaccgggagt 673501 aaaccctgac aacatattct ttacatggtg gtttcagctg attgctgcca tcgcagtcgg 673561 gggaattgcg gtttcaatca tgctttatca tgcaggcggc aaagtaacgg ttaatggaag 673621 tacatatatg gatcagcgta cgtctgatgt gattgatcaa tacgacactt atattagaac 673681 gactgtaaca agagaaagaa aaccatcaga taaagacagc ggcagcgatg gcggtgttac 673741 gaaaggcggc acgtcataca gtgggagccg gggcagtttt taaatgtaag aaatagagaa 673801 agggagaggc gtaatgtcgt ttttcagaaa tcaattagcg aatgtagtag agtgggaaga 673861 atttagagat gatatgattt tttataaatg gaacaatcgt gaaatcaaaa aagggagccg 673921 tttaatcatt cgtcccggac aggatgctgt ctttttgaac aatgggcggg ttgaaggagt 673981 ctttcaagat gatggcgatt atgatattga atcagaaatt attccattcc tttcaacgtt 674041 aaagggcttt aagtttggct ttaacagcgg catgcgagct gaggtgctgt ttgtcaatac 674101 gaaggaattt accgtaagat ggggaacaaa acaggcgata aatattccgg cagcgggaat 674161 gccaggcggg atgcccattc gcgcaaacgg cacatttaat ttcaaggtgc aggactatat 674221 cagcctgatt gataaaatcg ctggcgtgaa agatcaatat tttgtagagg atattaaaac 674281 ccgtatcatt tctattctgg atcagcttct catgaagtgg atcacaagag aagggaaaga 674341 tatgtttaat cttcaagcaa acgcttttga tattgccaag ggaattcaag aggacttaga 674401 tatgcaatta ataagcgacg ggatgacggt cactggtttt caaatcatga gctttaatta 674461 tcctcaagag gttcaagata tgattacaaa gaacgcttcc tacggtatgg ttggggatgt 674521 gaacagatac cagcaaatat caatgacgga tggaatggca tccggaaaga tgagcggaag 674581 cggagcggct tcggatatgg ctggaatgat gatgggaatg aatatggcca atcagatgat 674641 gaaccaaatg aatcagaatc agcaggcaca gtcatcaggc ccacagtcaa ctggcagcgg 674701 aagcaaaccg aatttctgtc caaactgcgg aacaaaaacg ggcgaagcca atttttgtcc 674761 gaattgcggc cagaagcttg tataagaatc atacagtgaa aagtccggag tgatcagcac 674821 tcgggacttt tttatttagg agaataagca ttacctattg cttgctcctg aacaggccat 674881 tttcgagccc ccgcttggat aattcccagc agcaattgac gacgttcctt tattgaattg 674941 acggcaattt gaaatgtttg ctttgataaa gccggtatgc ctgattgttg aagctttgag 675001 atgtctggtt ctggcggcgc ttgttctgca ggatggatat aggcagtatg aacggtatcc 675061 agatagtttt tgatacttga gcgcgcttct ttgatatgaa gctgattcgg ctgatattgt 675121 tcaggaattc cgtatttgaa aatggttaga gcctcatcca atacagcaac agctataatg 675181 gatgattcct gatgctgcgt gctgtggtaa aaatgaagga tggggaaggc gttatgctga 675241 gcggtcagct ttcccagttc tgatgaggca gcgacaagaa gaaaatcaat gtcgtgaaaa 675301 tctttgccat tccatgcatt atggacgatt tcagttccgt catgccctag acttaataca 675361 ctttgggcaa aggagcgttt ttgattaacc gcactcaaga cggaaatcaa atacgtgaca 675421 gaaaatgtga tggtaagcag tccttgagct gtttcaataa tcgtgacaag cttccatagg 675481 cctccgttcg gagcgaggtc gccatttcct aatgtaaaca tgacatagcc ggaaaaataa 675541 attcggtctg accaggaagc cggttctttt gattgagttt ccataagtga gtgagggtca 675601 ctcgagtaaa tcaaaaccca cccgctccaa aatagactga tccatatcac taacgtcagg 675661 cataacagca gaggaccagc catacttaga acctttgcgt ggtcaccgct gattttgcgg 675721 cagcccttcc acagccaggc agacaggcat cttgtgatcg ggccggcacc gctctctaac 675781 cataacgtgg tccataaaaa atcaatcatc cccgctgtca ataataaaag gcctgcaatg 675841 atataaccct cattcatttt ggttgcctcc cttaagtcag ccttctttta ttttcttctc 675901 tatttccttt tatcctgagt ctgaaacaat tgaacgaatg tttgatttta cagagaaaaa 675961 taggtgggag ttacccaaca cttactcatt tttcaatatg aacagaaaat cacaagattt 676021 ttgacttgat tcacacattt tcatgaagaa aaacgttcat tttccccttg aattggtgat 676081 tttcctttta tagagtaaaa aattttcaga aatttatatt gactgaaagc gtttttataa 676141 ttatgataat atcagatata acaaaaatgt cactataaca tcactacaat tgaactatta 676201 agtgactaat aaataccaaa tgaacgaggt tatgcacaaa gaaatgacca ttgttctttt 676261 aacgagaaat gaaatcgctt ccatagggat tgacatgcta agaagaaggg aaggttatga 676321 ggttattgga taaaaacatg aacaactatt ttctgaagcc tgcttacgaa atgtgaggaa 676381 ggcagcagcc ctggaataag tttttgacat acgcattttg aaaaagactg ggggaaacag 676441 tatgaataaa caaggaaatc aaatgtcatt tttacgtaca attattttag tctccacttt 676501 cggcgggctt ctttttggct atgataccgg tgtgctcaat ggagctttgc cgtatatggg 676561 agagccggat cagcttaatc tcaatgcctt cacagaaggc cttgtcacca gttcacttct 676621 ttttggagcg gcactgggtg ctgtgtttgg cggcaggatg tctgatttta acggccgccg 676681 caaaaatatt ttgttcctcg ctgttatatt ttttatttca acgattgggt gtacgtttgc 676741 accaaatgtt acggtcatga ttatttcccg ttttgtgctc ggtattgcgg ttgggggtgc 676801 atccgtaacg gtgcctgcct atttagcaga gatgtctcct gtggaaagca ggggacggat 676861 ggtgacgcag aacgaattga tgattgtatc aggacagctt ttggcctttg tttttaatgc 676921 gatccttgga acaacaatgg gagacaactc ccatgtgtgg aggtttatgc tggtcattgc 676981 gtcacttcca gccttgttcc tgtttttcgg catgatcaga atgcccgaga gtccccgttg 677041 gcttgtttct aaaggaagaa aagaagatgc tttgcgtgta ttgaaaaaaa tcagggacga 677101 aaaacgggca gcagctgagc tgcaagaaat tgaattcgct ttcaaaaaag aagaccagct 677161 tgaaaaagcg acatttaaag atctttcagt cccatgggtg cgccgtattg tgtttattgg 677221 attagggatt gcgattgtac agcaaattac aggtgtgaat tcgattatgt attatgggac 677281 tgaaattcta agaaattccg gtttccaaac ggaagccgct ttaatcggaa atattgcgaa 677341 tggcgtgatt tcggtattgg caacattcgt cggaatctgg ctgctgggaa gagtggggcg 677401 ccggccgatg ctgatgacag gcttgatcgg tacgacaaca gcattattgc taatcgggat 677461 attctcactt gtacttgaag gatcaccggc acttccgtat gtagtcctgt cattaacggt 677521 cacatttctt gcttttcagc agggcgccat ttcaccagtg acttggctga tgctatctga 677581 aattttcccg cttcgccttc gcggactggg aatgggtgtt acggtattct gtctgtggat 677641 ggtgaatttt gcagtcagtt tcacgtttcc gatattgctg gcagctatcg ggctgtccac 677701 aacgttcttt atcttcgttg gattaggaat ttgctctgtc ttgtttgtga agaggttttt 677761 gccggaaacg aaagggcttt cgcttgagca gctggaggaa aacttccgcg cttatgatca 677821 cagcggggca aagaaggatt ctggggctga agtgattgga taatttaaaa aagaatccgc 677881 acccgagtgc ggattctttt tggtttcaaa ttagttaggt ctaacaagga ttttgacttg 677941 gcttttctct ttaataagag ccccgaagcc ttcctcgatc aaatcatcta gtacgatttt 678001 tttcgttacg agtttgtcgg ctgagaaata gccttctttc attaatgaca atacagccgg 678061 gaagatgtcg cggtatccga taattccttt tactgtacgt tctttgatta cgatatcgtt 678121 cggatggatt tcagcacctt tttcccaaat gctgacgatg acggtttcac cggcaattgt 678181 agtggactgg atggcttgtc gtaacaccac tgggacacca gtgacttcga atgctacgtc 678241 aacaccgcct cctgtacgtt ctgcaatctc agcgactaca tcgtctgttt tagacggatc 678301 aacgatgatc gcgccaagct cctcagcttt ttgctggcgt tcaggagaaa gctcaacagc 678361 gtaaatatca gttgcaccgg cagccttcag cgcttcaatg acaagaagtc cgatcgggcc 678421 gcagccgaat acagccgctt tgtcgcctgc tttgagtttg cttgagcgga cagcgtatag 678481 agcaactgca gaaggttcaa cgagcgcgcc ttgttcatat gataattcat caggaagttt 678541 gaacaaaagc tcttcatcca cagagacgta ttcagagaaa ccgccgcctc cgccggctaa 678601 gccgaggaat cccatttgtt catcaaggtt gtaggcgcct tggtggccgt gtgtagcaaa 678661 aatcggctcg actacaacgc ggtctccaac tttataattt tcaacgcctt ctccgacttc 678721 gacaacttca ccggagaatt catgccccat tgtgacaggt gccgtttcat ttgttaatgg 678781 gtgcggtttg tcaaccggaa taaagatcgg gccgcccaga tattcgtgta aatcacttcc 678841 gcagatgccg caccatttga ctttgatctt tacttttccc ggctccgttt ttggctcttc 678901 gatatgttca atacggatat ccttttggtt atgccatctt gctgccttca tggattacca 678961 ctcctataac ttttgatgtg agtaattccg caccggtcaa tatgaactgt tcacaaaatc 679021 gccattttta aaaccaaaaa agaaatgaaa tttttatata atataatcta cgtttttttg 679081 aaaaaaagaa actttaaaga aaaaagggtc tcgcacactc ttttttcttt atatgagagt 679141 atcaatcgtt tacatagcta tgaatttggt ttgaacaata cggtaatggt tcgttcatat 679201 tgaatgcgac aactactcta tcaataatta taactctaat actgctatta taataggata 679261 atcttccatg gtttatttta gcagaggtaa cttttttgac tttgtaacat tactgtaagg 679321 atattgaaat aaaaaatagc tggttgatcg tgtataatct tcctagatgt taacaaacag 679381 ggggacgaaa tgttgaagaa agtcatttta gccgctttta tcttagtagg aagtactttg 679441 ggagctttta gtttttcatc agatgccagt gcgaaacatg tgaacggaaa tattacttgg 679501 tataatggag tcgggaaaaa aggctcttca ggtaagaaac ttggacattg ggattgtgcg 679561 accaaaatcg gatttgatgt tcctagaaac gggacaaaaa tcagagctta tgcaaaagcg 679621 aagcctaaaa aggtgattac ggtttataaa aatgatgttg gcagaatgcc taatgcagtg 679681 ctggatgtta gccctaaagc gtttaaagcg cttggatacc cattaagcaa aggtaaagta 679741 gcggggcatt acagctatta atgtacatat ataatctgga aagcaagaag tcacattctt 679801 gctttttcta ttggtggaga taaaagatga aaaaaagaat catattatta ttagcagtga 679861 taatagcggc agctgccgcg ggggttgcgt tttatgttgc aaaggataaa ggccatgaga 679921 aggctgctga tgtttcagtc aataccgaaa gcggtgatga gctgctggtt tcaattacag 679981 atacggatct gctgacaaag tattatgaaa atgacaaggt gatccatgag gagaagctga 680041 ccagctatcc ggcatttgcc ttggatcaaa aacagcaggt gctctattat acgggcaata 680101 atgaacagaa tgaaatgagg ctttttaaat tggatctgaa gtctcataaa aaaacgatgc 680161 tttataaagg cgcggagagt gcggacagtt tatttttatc aaaggaccgt tcaaccatct 680221 atttccgctt aggaaaagcg gacgaaagca attttcgaat cgccgctttt gatctgaaga 680281 cgaaaaagta taaaaatctt tatcctgccg ctaatgatca ggatgacacc gtcagcagct 680341 tcttttataa ccaaaaaaac gattcatttg cattgcttca ttattctgta gaagaagact 680401 acaagaaaac agatgaagca aacgaaaagg gcatcgaccc tgaaccgaca acgattcatt 680461 ttgcggaagg ccgccaaaat aaatttaatg agctgaaaag cctgaaccaa tttatcagcg 680521 atattgctgt ttctgatgat gataaacgta ttttattcac atcatatacg caaaaaggaa 680581 cggagcaaac cgcttctatt caaatgctca atgcggatac gaaaaaatat gaaagcatca 680641 tctcaaatca aaaatcattt aagctgttaa ttgacgcaca gcctcagttt tctaaggatg 680701 ggaagaacat ttattttctt gccgaagcca agggggctaa aaagctgaag gacgaaacag 680761 ggcgtgaagc taaggtgcgg acgatttatt cctatagcct tgagaataag accttcaaaa 680821 aagtatggga aaatccgaac ggcatcatca acagcttttt tgtgattaac taataaaaac 680881 cactcggcat gagctgagtg gcttttttaa tggatgaggt gcagggctaa tgatccgagc 680941 catttaaaga tatgaatcag aggtaccgac aaaaacagaa gttcaacata tgagttcatt 681001 gcaacattca gctttttgaa cgcagctctt tttttcaagt ctttttgctg ctggtttgag 681061 atcacgttat cactcctctt atatccatat tataccatta aaacagacaa aaaagcccta 681121 aacgtttaca gttttgggct tctttcttcg tatttggcct cttgcaatga gaggctttta 681181 ttctgaaata tagaattttg tctccgttcg gggtttgttt gcttgcggga gactgcattt 681241 gttataggga agaactagct tgttttcgtt tggctgttgt tttggagatt cactaatgaa 681301 cggatgccgt cgaccatttt acttccgcac aaagggcaca atggcgtatc actgctggcg 681361 aagttttttc gggtccagcc attacagtct tcttttgtgc attcccaagt actcacatct 681421 tcctttggca gcggttcttg atttcgtttg ttatagtaag acataaagtc acttcttccc 681481 tcatgtattt tactgcacat ttcctattgt ctcatacttt tccctaatct cctaattcct 681541 ttttctttat gactttccaa taaccccatc taaaaaggag aggagtgtgc tgttaaaagc 681601 atctggctct tctaaaaacg ggcaatggct gcttttagga aaggtaacga gtgtcgcgtt 681661 tggaatattg ctgcgcaagt gttccccagc tgctgtagag aaaaatttct tgtcttcccc 681721 gaagcacagc aatgccggca cattgatgtt ttggagggtg ccccggtaat cagcggccgt 681781 ttggttaaat aaaatcgtgc tagaaatggc agccggctgt ttgaggattt ctgccagcat 681841 ccattctgtt tcggtctcgg caggcggttc tgcgaacata ttctggatga agctttcgta 681901 gaaaggcagc gggtcagttt gaatggcgtg catcgctgtt tttaagccgt caaaatcaaa 681961 tggaccatgt tcccagccct cccattgata gtccgaagcg gattgatcga tgatcacagc 682021 ggcttgaatg ttatcattcc caaactgatt gagataatcc catacgacaa aagcacccat 682081 tgaccagccg gcaagaacga catgatcaag ctccattgca tttagaaatt cccttatgtc 682141 acgggcatat tgggaaatgg tgtggccgtg aagcactttg tcagattcgc cgtgtcctct 682201 aagatcaaga cgaatacatt gataattggc agaaagcacc gaaaattgtt tgtggaaaaa 682261 ttgtccgctc atcagcaccc catgtataaa caggatcggc gtcccgctcc cgtgtgtttc 682321 atagtaaagg cgtgtctgat cttctaatat gatgtatggc atgtttctcc tcctttagtt 682381 tccatcatga gtatggctgg ctgctgttga gctgatgatg gcagctgtcg cggctgcctg 682441 ctgcgcttga atgactgttt cgatagcggt gtatagtcct gattccatca gcagattttt 682501 ctccatatgc tcactgagat agaggctgac agcaatttta aagttcattt ccttttgcca 682561 tttaaaagct ttttcctggt ttaattcgtc agtgatgcac aaaacggttt tgatatctgg 682621 ctcttccaga aatgtgagga gagcaaggtc tggataatga taatcctttg tttttttgac 682681 agattcagtg atcgattgat atatctgttt gcaagcggaa acaagcattt cgggctcttt 682741 ttcactttgc aaggccagaa tatggctgac ctgatgtaag tactgtcctt ttttaaagcc 682801 gttggctgcc agcagttgat agcatgtttc cgccttctgt agcgcctgca aaccttttcc 682861 gttttctcca agcagtacgg caagcggaac attctgagtt gaagtgagga aataatgatt 682921 tttcttcatc tgctgataaa cagctagccc catgttcatc tgttcttttt ggtttgtcgt 682981 ttcagatttg ccggtgagca agatcagagc ggaaaggtat gtgaacatat cccgcttata 683041 ccctagcttc accatttcat tgtatacatc gatgaaagtc tgaaatgttt gttttgcctc 683101 atgctgaaaa tgaatgtcca gaatagatgc aacagtaaag cggtggtgtg aattgagtgt 683161 tgagaagctg ccgatgtttg atttgatata gctgctcaaa tcataaaagc gctgaaaatc 683221 aaactctctt ttattcacaa tatatgcaga agaaatgagc attaatatct gatcgtgtga 683281 aactttccat tttaattttg tttttaattc agcataaatg gaaatgtaat gctttgtttt 683341 ttcatgtaga tcgtgtgtga gcataaaaag cagctccttt tgttgttttt acgtaatacg 683401 ataaataggg ccaaaggttt cataaagaaa aaacttgcct gctagaggca agtttgtcgg 683461 gttatttatg gggatcagtt atatccatcg gtctcatcat gtcatagtct tcatgctcta 683521 gaatatggca atgccatacg tatcgtccgc tgtacggacc gaatgtcgcc gcgattctca 683581 ggacttcacc tgcatgcgct tgaatggtgt ctttccagcc cttttcactt ggcggcggcg 683641 ggacagccgg accggtatag gacaattccc cgctttcttg ataacgggcg atatcaaacg 683701 gccgccggtc taatacacgg aaggagacta gatgcaggtg gatcggatgt gttccgcgtg 683761 tcgggttgat aatggaccat atttcagttg tgccgacttt tggtgtttct gtgacgggat 683821 cgtgccagcg tttgttatta agcagaagga cgggtctgcc gtattcgtcc tgggtgcctg 683881 ccagttttaa cgttctgatg ttttgtattc tttcatgctg taccgaaggg tatgaggcga 683941 ggtacttcgg ctttctgctt tcgtcttttt gtgccaatgg ttttgtgact ctgaattgca 684001 tgatattcgc atctgtttca ggattgacgt caccgccgca gcccgcgctg tttgccaaaa 684061 tgatcgattc tccttcatat gctgtgaagt caatgatgat atcgtaacgt tcagcaggcg 684121 caaggctgaa agaattcagt ttaacagatc gcggcaggag ccctccatct gaaccaatct 684181 gaataaaatc tccgccatta tcgagtgaca ggttataggt tcttgtattg gaggcgttga 684241 tgacacggaa tcggtatttc cttggctcga cttccaagta tggccatacc ttcccgttga 684301 cgagtatggt ttctccgcaa aaagccggaa cgattgaagg attaggcagt gacggagaag 684361 ggttttccgg tgcgctcgga taaaacaaag aaccatcctc attgatcgtg cggtctgtga 684421 taagaagcgg cacatcgtat tcgtctgaag gcagttttaa gcgtttttcc tttgggtcat 684481 gaatgatata tgcaccgaca agtccggcat agacatttag cctggtgagc gccatggcgt 684541 gatcgtgata ccacaatata gccccgcgct gctggtttgg ataatgataa acctctcttt 684601 tgaaataagg tcctgtttgt tcaaagtctt tggaaaacca agcctccgga tacccgtcac 684661 tatcatctgg cgtgacgccg ccgtgtaaat gaacaacagt ctttacctcg ggctcttcat 684721 gctggctgtc actgtgatga atggtgtgat caatcggaag gaaatgcgtg gaaggaaggt 684781 tattcatcca ttttacatat acgttttcat ttcttttaac ctcaatggtc ggtcccggaa 684841 ataagccgtt gtagccccac aggcgggttg gagggagatc gcgatggagc tgatgagtgc 684901 attcctccat ggtgacttcg tagtatgttt tttcttttga ttgctgtact ggctttagtg 684961 tatctgggat tgggagagca tccacaaatt tttcaagtgt cattttcatc tgtccttatc 685021 taaattttcc aaattggtac tatagttaat gacaataagg acgtgatggt tacaaaaaat 685081 cttcgtgctg cagcccgccc gaagaagaaa ataacaaaat cctaaacggc aggccgttta 685141 ggatttgatc agcattaagg caggatatcg ggttgctgct gtgtgactgg gttggcagcc 685201 gctttctcgc tcaccttgcg ttttctgaac acaaggtaag aaatcagaac gattcccgtg 685261 atgacgcctg tcagcagcag ctcgtctctc atggaatcaa taaacgccat ggacactaaa 685321 attccgcaaa tggcgatgat ggtcaagtag gttaggaaag ggaagagcca cattttgatc 685381 ttcaatgctt ctgggtttgt tttttcgagt tttttccgca ttttcagctg ggaaacggcg 685441 atgacaagat agacgagtaa agcgattgcg cctgatgagt tgactaagaa taaaaagacg 685501 gtatccggtg aaaaatagtt cattacgacc gcgatataag agaaaaatgt cccggccaca 685561 atggcttgta cgggaacgcc ttttttgctc aatttcataa aacggcgcgg cgcttcattt 685621 ctttctgcaa gtgaatacag cattctggat gtggtataca aacctgaatt caggcaagag 685681 agtacggctg tgaggacgat aaagttcata atctgtgcgg ctgcgggcac tcctatatgc 685741 tcaagtacag cgacgaaagg gctttctaaa atatttgctg aattccatgg caacagcgcc 685801 acgacaatgg cgattgagcc cacgtaaaag acgatgatgc gccatacaac ggatctggtg 685861 gcttttgtca cagattcgat cgggttggat gtttcccctg ctgcaatggc aacgatttca 685921 gttcccataa aagagaagat gacaacgaca atgccgagca atacggagct gatgccctcc 685981 gggaaaaatc cgcctttgcc tgtaagattc gaaaaaccga ctggctcact gcccggtgca 686041 aagccaaaaa taaaggcaaa accaacgatt agaaaagcaa tgatagtcac aactttaatg 686101 agggagaacc aatattcaaa ctcaccgaaa gacttaacgg agtagacgtt tgtcagggtg 686161 agcacaatgg tcaagatcaa acttgtcagc cacagcggaa tatcatggaa ccagtattga 686221 ataatgccag caccggcaat ggcttcgatc gctatgacga tcacccagaa aaaccagtac 686281 agccagccga ttgtaaatcc tgcccacggt ccgatggcgt cgtgagcgta ttgagaaaac 686341 gatccgctcg tcgggtttac ggcagacatc tcaccgagca ttctcataat aaaaatcacc 686401 aataatccgg ctaacgcgta agaaacaacg gcacccggac cggtcgagtg aatcactgaa 686461 ccgctgccta caaataggcc ggctccgatt acaccggcaa tcgaaatcat tgtcatatgg 686521 cgggtcttta attccttttt taatcctgat tgagactggt tcataagtta cctcctttta 686581 aaatgcaatc attactgaat attatgataa ttgaaactct atcataaata tacagtttgt 686641 cgaaaattcg tgtaagaaaa tataccagct tatttcaaat ttgtagtgtt ttgtttgcgc 686701 tttcagcgaa tgtgtggaaa aaatgtttcg ttttttattc gctgtgtgat tttgcgtaat 686761 atttacaatt cgatagaatg cgagaagcac tggtgtcctt gggtttgatg ggatttttgg 686821 cggagcaaat aaattggatg agagaaaaag tgttccttcg tcactatttt tctgtggcgg 686881 gtgaatcatg tttctgtaga cccactgcgg atcagctttg taagataata ataggaaaat 686941 gtgagcgaga ggaggttttg tatggagaga tatgatgaac tgaaaaaggg agaatccgga 687001 gcgctggtca gcattgccgc gtatctagtt ctttccgcaa ttaaactgat catcggttat 687061 ctttttcact cggaagcact tacggcagac gggttaaata acacaactga cattattgct 687121 tctgttgctg tgctgattgg cctgcgcatc tctcaaaagc ctcctgacga agatcatcca 687181 tacggccact ttcgagcgga aacgattgca tcgcttatcg catcgtttat tatgatggtt 687241 gtcggactgc aagtgctgtt cagcgccgga gaatctattt tttctgctaa acaagagacg 687301 ccagatatga ttgcggcttg gacggcagcg ggcggggcag tcctgatgct gatcgtttac 687361 cggtacaata aaaggctggc caaaaaggtg aagagccagg cgctccttgc tgcggctgct 687421 gataataaat cagacgcatt cgtcagtatc ggcacattta tcggcattgt ggctgctcaa 687481 ttccatcttg cttggattga tacggtcact gcgtttgtga tcggtctgct tatttgcaag 687541 accgcatggg atatctttaa agagtcatct cactctttga cagatggatt cgacataaag 687601 gacatttccg cttataaaca gacaatcgaa aaaatctccg gtgtgagccg tttaaaagac 687661 ataaaagcaa gatacttggg cagtacggtt catgttgatg tggtggttga ggtatcggca 687721 gatttaaata ttacggaaag ccacgatata gccaatgaaa ttgagcggag aatgaaggag 687781 gagcatgcga ttgattattc gcatgttcat atggagcctt tagaacaaaa ataatggagc 687841 ttcctgtcac aggaagcttc agcgtgtcga caaaccctcg cattcgttgt caggtctgcg 687901 cttcggtgct cacgaattag aacattcgct ccgctcctat gctcgtcctt cctagacttc 687961 aagggttttc aatcacgctg aaaagatgac aaaaccctaa aatgaaagcc attttaggat 688021 tttgtcaaca atctggagct tcctgccaca ggaagctttt ttgtgtgttt tggccagctt 688081 tattggtaac aatttgctag aatcgttttt ttatacagat tgctttttgt ggtaaagtta 688141 ggttacatta tgatgaattt tgtagatgac taggaggaaa ataatggcat atcaagaaga 688201 cctgcatcct ttgctgggga aagcagttga acatattaat agagtaatgg ttggaaaacg 688261 agacatcgcc atactcagct tagcagccct tcttgccaaa gggcatgtgc tgcttgagga 688321 tgtacccgga gtcggaaaaa cgatgatggt ccgcgcgctg gcaaagtcaa tcggcgccga 688381 tttcaaaaga atccaattca ctccggattt gctgccatct gatgtaacag gggtatctat 688441 ctataatgcg aaaacgatgg aatttgaata tcgtcccggc ccaattatgg gaaatatcgt 688501 gctggcagat gaaatcaacc gtacctctcc gaagacacag tcggctttgc tcgaagcgat 688561 ggaagagggg agcgtcacgg tagatggcca tacgatgcag cttgccgatc cgttttttgt 688621 gatggcaacg caaaacccgg tcgaatatga agggacctat cctttgccgg aagctcagct 688681 tgaccgtttt ttattcaaac ttcggatggg ttatccgtcc tttaatgaag agcttgacgt 688741 cttatctctt caggaaaaaa gccatccgat tgagacgctt gagccggtta ttgcaaaaga 688801 agacttcatc tttttacaga gggaagtgca aaatgtccgt gctgatgaca gcattaagga 688861 atatatcgtt gaaattgtgc agaaaacgag acagcatcct tctgttcaat taggcgtcag 688921 tccgcgcggc tcaatcgccc tcatgaaagc ggcacaggca tacgcgctgc tgcatcatcg 688981 cgactatgtc ataccggatg atattcaata tttagctcct ttcacgctgc cgcaccggat 689041 gatgcttcat cctgaggcaa aatttgaagg gattcaggca gaagcgatcg taagggagat 689101 catgtcagct gtgaaggtgc cggttcaaag gtcggcggtc cgctgatgaa taagaaatgg 689161 caatggctcg tatatggttg gaagctgatt atattaactt tattgacggc tgctgttttt 689221 tcttatgcga tgtttcaggg cggctttgtc agctggtttt tgttttacgc gtttctccct 689281 tttgtcttgt atgccgggct gttggccttg tatccgctcc gttcttttca ggcttcaagg 689341 caaatggata aaacacaatt gcatgcgggg gacaggctgg gcgtaacggt tacgctgaga 689401 agaaagctgc catttccgct gatgtatatg gtgattgaag attgcctgcc agaaggtatc 689461 gagtcattaa atcgagacgg agccgcggcc aaacggctcg tttttccttg gtttaaacgg 689521 agcatgacga tgtcgtatga attagctcgg gtaccgcgcg gagagcatca ctttcattct 689581 gtcagggtgc gaaccgggga tgttcttggc ttgattgaaa aaacagcatt ttttgagctg 689641 gatgatacct tgtttgttta tccattctat cagcgttttt cctatcaggt gaatgagagg 689701 catcaggaag acggtgtaag cggttcttct cctattcatc agcaccattc ctcagtcgca 689761 gcaagtgtgc ggaattatca gccgggagac cggtttgctg cgttagattg gaagacatct 689821 gcacggcgga gccagctgat gacgaaggaa tttgagcctt ctcgcagcaa aaatctgttt 689881 ctgctgatgg accgtttttc ctcagacgca ttcgaagagg tcgtttcagt gacagcttcg 689941 attcttcatt ctgttttaaa aaacggcgcg ggtgctggtc tggcttccat cgggaaggaa 690001 aaaaacattt tccctattca ggaaggggat cagcatttta agcacatgct tcggcattta 690061 gccatcgctc attgtgatgc ggcagacccg ataagccgat atgcacggga agagctggga 690121 aagccatctg ttcgccaagc tgatcaagtt gttgtcacgg gacagttaac ggaagatatg 690181 ctgcacctcg cagaaatagg aggcggccgg gttacggtga tactggcaaa agagaaagat 690241 gctgagctct ctcaagctga aaatgtcatg attgaacgca tgatgaaacg ccaaatcaga 690301 gttcggatca tgaggggcgg gcgagtttcg cgtgttgttt agaaagagag gtgactggtt 690361 cacatgccgc acgatgatca caagggaagc cgtttgagct tgctgttatt ttattttctg 690421 gcttttttat tgctgtggga gtggcttagg ccgcttgaca gttttactga aacgaaacat 690481 acaggctttt ttagtgtctt tatcggcttg acgtttctgc tgactttttt caggatgagg 690541 tggtttgtca ccgttccttt ttgtgtcata tttacattga tctcgataca catcctgttt 690601 tatcaaggat ctatattcga cttgagctgg gtcagctctt ttttgcagga tgtctatctg 690661 aatatcacgc tgattcaatc agggcaatgg aatgacatga ttccttcatt tcggaccctg 690721 ctgttttttg tgctgctgtg gctgctggtc tatctcctgc attattgggt gatttaccag 690781 agaagaattt tgtttttctt tttgatgaca gtagcgtata ttacgattct tgataccttt 690841 acgccatatg atgccacttt tgccgtaatc cgtatcgtgc tgatcggctt ctttatgctg 690901 ggccttttat acttggaacg cattaagctg atggaaagaa tcacactgcc aaaaacatct 690961 gtcctgaaat ggtttcttcc tttatctgta ttggttttgg ctgcaacggg attcggactc 691021 gccgctccaa aatcagagcc ggcttggcct gatccggtgc cttttcttaa aaaaatcact 691081 catcaagacc gcgtgtctgc aggggaaagc aaaatcggat acgggaatca tgatgaatca 691141 ctcggcggcc cgttccagca ggatgctaca cctgttttta catggcaggg aaaagagcgt 691201 acgtatttcc gtgtggaaac gaaggacacg tataccggaa aaggctggat tgaaacagac 691261 acaggcatgt cgtatcagct tagcaatgga aaagttgaaa atctgtggtt tgaccataag 691321 gttgcgacag agcgccgcac cgtccgtgta aaagtcgata agcactacgg gtataaccat 691381 ctgatgtatc cgattggtgc ggaaaccatt cagccaaagc aggctgtctc acttgaaatg 691441 aacggcaaca cggagcaaat ttctccgatc agtgaacaag ccggtgaaat cagaaatatg 691501 gggaattata cagtaacgta caattccccg gtctataagc tggatgaact gagaaaggta 691561 aaagtgagaa aaaacagtga ggagtacaca ttcagcgatc gctacatgca gcttccagat 691621 tcactgccag agcgggtgag aacccttgcg atcaaactga ctcaggatca cgacaatatg 691681 tttgataagg tgaaagcggt tgaggactat ttagggtcaa atgcgttcac atatgaaaca 691741 gaaaacgtga ccattccgaa gaatgatgaa gattatgtcg atcaatttct ctttgaaacg 691801 aaaatgggtt attgtgataa cttttcttcc gccatggtgg tgctcttgcg ctcggccggc 691861 attccggccc gctgggtaaa gggttatacg tccggcgaat acaaagaagc agggaacaaa 691921 aatggcagca tttacgaagt gacaaataac aatgcccatt cctgggtaga ggtgtatttc 691981 ccggaacagg gctgggttac atttgagccg actaaagggt ttacaaatcc ggctcaattt 692041 acatcttctg acacaaaaga ctctggcagc gatagcagca gctcgccgaa gaaagcaaaa 692101 gagaaacaga aagaagagaa aaaacagccg caaaaagagg aaaaacaaaa ggaaaagcgg 692161 gagccagctg tttctaaaaa gccgtccgct tcgcatacta atgccggtgc gggcttgtat 692221 gcagcgcttg cggttcttgc agtcctcctg gtggcagctg tattgctgta tgttttccgc 692281 tcgttatgga ttcctgtttt cgccgtgagg aaattgaagc ggcgcagtga tcagcacgcg 692341 ttttttgagg catatggcgc gctgctgaaa caactgaaga gaaaaggact gccgaaacga 692401 gacagtgaaa cgctgcgtga ttatgcaaaa cgaattgatg aaaaatacga catagaagac 692461 atgtcaaagc tgacattaag ctatgaaagg gcgctttaca gaaatgaaga ttcttcggcg 692521 ctatggaatg attcgagaga gttatgggaa aatttaatta aaagaagatg gtcttgaccg 692581 cttatcgacg tgttgttaga attagtgaat attatcggag tctgggagcg agttggcctg 692641 actccggcaa acggccttgc caaagagggc ggagcgagct tcatatctgt cctcgttttt 692701 ttctgtgtca aaaaacttag aggagattag gtgacaacca tgacaaagtt agtgaatgaa 692761 atgattcttg tccttgattt cggcagtcag tataaccagc tgattacacg ccgtatccgt 692821 gaattcggtg tttacagcga gctgcatcca catacattga cggctgaaga aattaaaaaa 692881 atgaatccaa aaggaattat tttatccggc ggtccaaaca gtgtgtatga tgaaaactct 692941 ttccgctgtg acgagaaaat cttcgagctt gatattcctg ttttgggaat ttgctacggc 693001 atgcagctga tgactcatta ccttggcggt aaagttgaag cggcaagcca gcgtgaatac 693061 ggaaaagcaa acatccgcat cgaaggcaca cctgatttgt tcagagatct tccgaatgaa 693121 caagtggttt ggatgagcca cggcgatttg gttgtagaag ttcctgaagg cttcactgtt 693181 gacgcgacaa gccatcactg cccgaactca gcaatgagca aagcggacaa aaaatggtat 693241 ggcgttcagt tccacccgga agtgcgccac tctgaatacg gcaatgatct tctgaaaaac 693301 tttgtattcg gtgtttgcga atgcgaaggc gaatggtcaa tggagaactt tatcgaaatc 693361 gaaatgcaaa aaatccgtga aacggtcgga gacaaacagg ttctttgcgc gctaagcggc 693421 ggcgttgatt cctctgttgt tgctgttttg attcataaag cgatcggcga ccagctgact 693481 tgtatctttg tagaccatgg tcttctccgt aaaggcgaag ctgagggtgt tatgaaaaca 693541 ttcagcgaag gctttaacat gaatgtgatt aaagtagacg caaaagatcg attcttaaac 693601 aaactaaaag gcgtttctga tcctgagcaa aaacgcaaaa tcatcggtaa tgaattcatt 693661 tacgtgtttg atgatgaagc ggacaagctc aaaggcatcg actaccttgc acaaggtacg 693721 ctttacacag atatcatcga gagcggtaca gcaacggcgc aaacgatcaa atctcaccac 693781 aatgtcggcg gacttcctga agacatgcag tttgagctga tcgagccgtt aaatacgctc 693841 ttcaaagacg aagtgcgcgc gcttggcaca gagctcggca ttccggatga aatcgtatgg 693901 cgtcagccgt tcccaggacc gggactcgga atccgcgttc ttggcgaagt aacagaagaa 693961 aaacttgaaa tcgttcgtga atcagatgca atcttgcgtg aagaaattgc aaatcacggc 694021 ttagagcgtg atatctggca atacttcact gttcttcctg acatccgcag cgttggtgtt 694081 atgggtgacg caagaacata tgattacaca atcggaatcc gcgccgttac atcaatcgac 694141 ggcatgacat ctgactgggc gcgtatcccg tgggatgtgc ttgaagtcat ttcgacacgt 694201 atcgtaaacg aagtgaagca cattaaccgc gtggtgtatg atattacaag taagccgcct 694261 gcgacgattg agtgggaata agaatcaatt aatggaaacc atctttttgg caattttgcc 694321 gggaagatgg ttttatttgt ttattacgaa caaaatccga ttttgcgcga ctattgttcg 694381 ctttttgtat tgttttttca aaatgaactt ggtacaatag acacagaaat caaataagat 694441 gaattcgtat aatcgcggga atatggctcg caagtctcta ccaagctacc gtaaatggct 694501 tgactacgta aacatttctt tcgtttgata taaataaaac acggttattt attcaaactg 694561 aaatccgtct gtagtcaagc gtcccaaaat gtattgggac gttttttatt tggcgttttc 694621 aggacagaat aaatagcaaa gagtgaaggg agtcaaatag cttgaaaacg ttttttcagt 694681 ttgatgagct gggcaccagc tatcgcaatg aaatcattgg cggattaacg acttttttat 694741 ctatggcata tattttgttc gtcaatccga ttacgcttgc tttggagagc gtgaaagatt 694801 ttccggaggc gctgagaatt gaccagggtg cggtctttac ggcgacagcg ctggcgtctg 694861 cagcaggctg tatcttaatg ggattaatag cgagatatcc gattgccatc gcgccgggta 694921 tggggctgaa cgcgtttttt gcgttttctg ttgtccttgg tatgggtatt tcatggcagg 694981 cagctttgtc cggtgttttt atttcaggtc ttattttcgt tgctctttct ttaacaggtt 695041 ttcgtgaaaa aatcatcaac gccattccgc ctgagctgaa attggcagtc ggtgcgggga 695101 tcggcctgtt tattacattt gttggattac aaggttcagg aatcattaca gcgaatcctt 695161 ctacgctcgt cacgatcgga aacattcaca gcggtcctgt gctgttaacg attttcggtg 695221 tgattgtcac ggttatttta atggtgcttc gcgtgaacgc aggcgtgttt atcgggatgc 695281 tattaacagc ggtagccggc atgattttcg gtttggttcc ggttccgact caaattatcg 695341 gcagtgtgcc aagccttgcg ccgactttcg gacaagcgtg gattcacctc ccggatattt 695401 tctctgtaca aatgctgatc gttattttaa cattcttgtt tgtcggattt tttgatacag 695461 ctggtacact tgttgctgtg gcaacacaag ctggtttaat gaaggaaaac aaattgccgc 695521 gtgcgggccg tgcgctttta gctgattcat cttctattgt gatcggtgcc gtgcttggta 695581 cgtctacaac aacttcttac gtggaatcaa gctcaggtgt cgctgcgggt gcccggtcag 695641 gatttgccgc aattgtaaca gggattctct ttttactggc tacgtttttc tcgccgctcc 695701 tatcagtcgt tacgtcaaat gtaacagcgc cggcgcttat tattgttggt gcattgatgg 695761 tggcgccgct tggcaaaatc gcttgggata agttcgaagt ggccgttcct gctttcctta 695821 ccatgatcat gatgccgtta acgtacagca tcgcgactgg tattgccatc ggatttattt 695881 tctatccgat tacaatggtg tgcaaaggaa aagcaaaaga ggttcatcca atcatgtacg 695941 ggctgtttgt cgtatttatc ctgtacttta tcttcttaaa ataaggaatg aaaaaccagc 696001 tgcactggca gctggttttt ttgttgcaaa agataaaacc atttcatacg atataccgtc 696061 atgtagatgt gccgccatgc tttacttaaa tggaaatgac ttgactgttc aggaaggctt 696121 cggtacctta tataagtgtt ttattttctt gctgaatggt attccgccgt atttttttga 696181 taggagttgc tgacatgacg gaagaaagaa aagaaacgtt tgaagaagaa attaaccaga 696241 gtgaaagaat agatgcagat gaagaaccgc tatcgagaat gtccagaaag gcgagccggc 696301 aaagcaagca gaagcaaaaa caaaagcaga aaccgcgcca ggaacgcggt gaatcaactg 696361 ttaaagacaa gcttgcgtct gtttgggcag ccatcaacag atattgcggt tttgcgttct 696421 cgattttaaa atctccggcg aaaactgtcg taacggatgg tttttctcat tataagtacg 696481 gtctgatttc aatgcttata ttcagtatca ttttttcaat tgggaattgg tttcagttaa 696541 aggcaagctg gaatcggccg ctcggtttcg gagaacgcca tcatgctttc tatgacgggt 696601 ttttagttgt tcttgtgtat ttgctgatct ttttcgcggt aatggtcttt gctatatggg 696661 ctgtctcccg ctatatgatg aagcagaagg tgacgttcag agaagcggct gccgtattgg 696721 gttcattgct tgtacccgta attgctgttt caatcctttg gctgatcttt gcgatcgtaa 696781 atatcccaat gctgacagta ctgtttacgg tgctgatctt gttttccatc ttttttatca 696841 tcgcgctgta tgtacagcgt gtgtaccagg cggcacaaga tgcaccaatt gattatatct 696901 attgtgtatt tgcagtagtt gcgatagcgc tgctgtttac ggcagtgact tggccgttta 696961 tttctgaata tattacggcg tcgttgattc cgctttaatg aaaaaaccgg ctaatcctag 697021 ccggtttttt tatgtcacac tttttacaaa tatatctaaa aaacatagtt gatttgtagg 697081 attaacccgt gtatgatggg gaaaatgctg aaaacgtcca gcgcaaaaac ctttatgttt 697141 aaggaggatg atggacatgg ctgatgtact tcgccgagca attaaccaaa agaagcaatt 697201 tttaaaaacc aaattactgc tctcggaatt ttatcaagga agaggggaac agcttgctga 697261 ctacacgctg agtgagcttg agaaagaata caagtccctt cagaaaatga aaaaagagat 697321 ctgacaatag atataaagag gtgagtctgc tgaaaagcgg gcttttttgt tttgattttg 697381 aaaaggcgag aaagagggta aactactact gttcaacaca taaaagcgtg tcgaaatatt 697441 ttgcttaagc ttacgggcga agctgattgt aaacggctca tttctctagt agaatatgaa 697501 tgctttgtgc aagctgaaga gtagggggat gaataaaatg atgcaaacca tcttatcaaa 697561 tgggatagcc atggttctca taattctcat tattaatatt gtctatgtgt cattttttac 697621 gataagaatg attttaacgc tgaaaggaca gcgttattta gcggccggca tcagtacgat 697681 tgaaatactg gtttatgtga caggactgag tctggtgctc gataacttag accagattca 697741 aaatgtgatc gcgtacgcgc tcggttacgg tcttggcgta attgtcggca tgaaaataga 697801 agaaaaattg gcgcttggct atattatggt caatgtgatt acgaaggagc tcgatcttga 697861 tcttccgaag cagctccgtg aaaaaggcta cggcgtgaca aactgggtgg caggcgggct 697921 tgaaggcgac cgcacagccc ttcagatcct gacgccgaga agatatgaac tccagctata 697981 tgatacgatt aaaacacttg attcaaaagc ctttattatt gcgtacgaac caaaaacaat 698041 ccacggcggc ttctgggtca aagcggtgaa gaagaggaga attaaagaat aatggcaaag 698101 ccgaagaaga aaaagtttga agtgacagag cagcaaacga ttgatgcggt gcttcagcaa 698161 atgaaagaag aaggatatct gcctgtaagg cgaatggaag agcctatttt tatggaaaaa 698221 aaggaaaatg ggtcaattca gatcgttccg tgcgggaaaa aaatcgtatt tgaagggaaa 698281 ttgatctaaa acacgaacat tagtagaatg aatttttgta tcgttcgata atatcgttga 698341 cattatccat gtccgttgtt aagataaaca tgaaatcaaa acacgacctc atataatctt 698401 gggaatatgg cccataagtt tctacccggc aaccgtaaat tgccggacta tgcaggaaag 698461 tgatcgataa aactgacatg gatatatcgc agaagcgaac gactgacgat acatgtacca 698521 tgcccggttt gtattgcttc ctcataagtg caatgcagag cgggtatttt ttattttctg 698581 aaaacaaaag cattagaagg tggggaacag aatgcagccg ctagtaggaa tcatcatggg 698641 aagcacttcc gattgggaga caatgaaaca cgcatgcgac atacttgacg aactcaatgt 698701 tccgtacgaa aaaaaggtcg tttccgctca ccggacgcct gatttcatgt ttgaatatgc 698761 tgaaactgct agagaaagag gcatcaaggt gattattgcc ggtgccggag gagcggcgca 698821 tctgccaggg atgacggctg cgaaaacaac actgccagtc attggagttc cggttcagtc 698881 caaggcgctg aacggaatgg attcacttct ttccatcgtc caaatgcctg gaggcgtgcc 698941 tgttgcgaca acatccatcg gcaaagcggg tgctgtgaac gcaggcctgt tagcggcgca 699001 aattttgtca gcatttgacg aagaccttgc ccgtaagctg gatgagagaa gagaaaatac 699061 aaaacagaca gtgttagaaa gcagtgatca gcttgtctaa acaaatcatc tatccgggag 699121 ctgtaatcgg cattatcggc ggcggccagc ttgggaaaat gatggctgtg tccgccaaac 699181 aaatggggta taaagtcgcg gtcgttgatc cggtgaaaga ttcgccgtgc gggcaggttg 699241 cggatgtcga aattaccgct cattataatg accgtgaagc gattcgaaaa ttggctgaaa 699301 tcagcgatat catcacatat gagtttgaaa acatcgacta tgatgcgctg cattggctaa 699361 aagatcatgc gtatctcccg caaggaagtg agctgctgct tattacccaa aaccgtgaaa 699421 cagagaaaaa agcaattcaa tccgcgggct gtgaagtcgc accgtacagc atcgtcaaaa 699481 caaagaatga attgaaacag gcagtacagg agctcaggct tccggcagtg ctgaaaacat 699541 gccgcggcgg gtacgacggc aaaggccaat ttgtgataaa agaagaggcg caaatggagc 699601 aggcagccgc tctgttagaa cacggaactt gcattcttga aagctgggtt tcttttaaaa 699661 tggaactgtc ggtgatcgtc gttagatcgg taaacggtga aatttcaaca tttccgacag 699721 ctgaaaacat tcaccacaac aatattcttt tccaaagcat cgtgcccgca cgggtagaga 699781 aagggattca gcagaaggct gctgatctcg cagttaagct tgcagatgag cttaaccttg 699841 tcggaccgct tgctgttgag atgttcctga cagaggacgg agagcttttg gtcaatgaac 699901 tggcgccaag accgcacaat tcagggcatt atacgctgga cctttgcgag acgagccagt 699961 ttgagcagca tatcagagcg gtatgcgggc ttccgcttgg gaagacagat ttgctgaagc 700021 cgggcatgat ggtgaatctt ctcggcgatg aagtgaagct tgttgaggaa gacccggagc 700081 ttttaaaaga ggcaaagcta tatatatacg gaaaacatga aatcaaaaaa ggccgcaaaa 700141 tggggcatat tacatttatg aagcagcctg aagacgaatg gattcaggag atcacaaata 700201 aatggatgaa tagagacgga ggacaagcag aatgatcgaa cgttattcaa gacctgaaat 700261 gtccgcgatt tggacggatg aaaacagatt tcaagcatgg ttagaggttg aaattcttgc 700321 ctgtgaagcg tgggcggagc ttggcgtcat tccgaaagaa gatgtaaagg ttatgcgcga 700381 aaacgcgtca tttgacatca accgcatttt agaaatcgaa aaggacacgc gccatgacgt 700441 tgtcgctttt acgcgcgctg tatccgaatc actgggcgaa gaaagaaaat gggtgcatta 700501 cggcttaacg tcaactgacg ttgttgatac ggctctttcc tacttattaa aacaggcaaa 700561 cgatattttg ctcaaggatc ttgagagatt tgttgacatt ataaaagaaa aagcgaaaga 700621 acataaatac acagtcatga tggggcgcac acacggcgta cacgctgagc ctacaacatt 700681 cggcttaaaa cttgcgcttt ggcatgaaga aatgaaacgt aatcttgagc gcttcaaaca 700741 agcgaaagca ggcatcgagg ttggaaagat ttccggtgct gtcggcacat atgcgaacat 700801 tgatccattt gttgaacaat atgtctgtga gaagctcgga ttgaaagcag caccgatttc 700861 cactcaaacc cttcagcgtg accgccatgc tgactatatg gcaacacttg ctttgatcgc 700921 gacaagcatc gagaaattcg ctgtggaaat ccgcggactg caaaagagtg aaacacgtga 700981 agtagaggaa tttttcgcga aagggcaaaa gggttcatct gcaatgccgc ataaacgaaa 701041 tccgattggc tctgaaaaca tgacaggcat ggcgcgcgtg atccgcggct acatgatgac 701101 agcttacgaa aatgttccat tatggcatga gcgcgatatt tctcattctt cagcagaacg 701161 aattattctt ccggatgcga caattgcgct gaactacatg ctgaaccgct tctccaacat 701221 cgtgaagaac ttaacggtct tcccggaaaa catgaagcgc aacatggacc gcactctcgg 701281 ccttatctat tctcagcgtg tgctccttgc tttgattgac acaggcctga ctcgtgaaga 701341 agcctatgat acagttcagc cgaaagcaat ggaagcgtgg gaaaaacaag tgccgttccg 701401 cgagcttgtg gaagcggaag agaaaatcac gtcacgtctt tctccagaaa aaattgctga 701461 ctgctttgat tacaattacc atctgaaaaa tgttgatctg atctttgaac gtttaggttt 701521 agcatagaag aagcttttag cggcttcttc taagccgccg cagtttgaaa attcccaaca 701581 ttcgggttag gaggccttcc gtgaatattg tgaagaatga acttttatac gaaggaaaag 701641 caaaaaagat ctacaaaacc gatgacgaaa acacgctgta tgtcgtgtat aaagactccg 701701 ccactgcctt taacggcgag aaaaaagcag aaatcagcgg aaaagggcgc ttaaataatg 701761 aaatttcaag cctcattttc aaacaccttc atgctaaggg cattaacaat cattttatcg 701821 agcgcatttc ggaaacggag cagctcatta aaaaggtaac gattgtgccg cttgaagtcg 701881 tggtaagaaa tgttgtggca ggaagcatgt ccaaacgtct cggcattcca gaaggcacgg 701941 agcttgagca gccgattatc gagttttact acaaggatga cgcgctgggt gatccgctca 702001 tcacagaaga tcatatttgg cttttgaagg cggcgactcc tgagcaggta gaaaccatta 702061 agtccattac aacaatagta aatgaagagc ttcaaagcat cttcgacgat tgtcatgtca 702121 gattaataga tttcaagctt gaattcggtt tagatgcaga agggcaagtg cttttggcgg 702181 atgaaatatc tcctgacaca tgccgcttgt gggataaaga aacgaacgaa aagctggaca 702241 aagatttatt cagacgcaat ctgggaagct taaccgacgc atacgaagag attttcaata 702301 gactgggagg cattcatcat gtataaagta aaagtttatg tcagcttaaa agaaagtgta 702361 ctagatccac aagggagcgc tgtccagcat gccttgcaca gtatgactta caacgaagtt 702421 caagatgtgc gcatcgggaa atacatggag cttaccattg aaaaatctga ccgtgatctt 702481 gacgtgctag tgaaagaaat gtgcgaaaaa cttcttgcga acacagtgat tgaagattat 702541 agatatgagg ttgaggaggt agtcgcacag tgaaatttgc ggtgattgtg ttacccggct 702601 ccaactgtga tatcgatatg tatcatgctg taaaggatga gctcggccat gaagtggaat 702661 acgtctggca tgaggaaaca agccttgacg gcttcgacgg cgtgttaatt ccgggaggat 702721 tttcttacgg cgattactta agatgcggcg ccatcgcccg atttgcgaat attatgccag 702781 ctgtcaaaca agcagcggct gaaggaaaac ctgttcttgg cgtctgtaac ggattccaga 702841 ttttacagga gcttgggctg ctgccaggcg caatgagacg caacaaagat ctgaagttca 702901 tttgccgtcc ggttgaattg attgttcaga acgacgaaac cttattcaca gcttcctacg 702961 aaaagggaga atcgattaca atcccggttg cccatggtga agggaatttc tactgtgatg 703021 acgagacgct tgctacatta aaggaaaaca atcaaattgc tttcacatac ggctctaata 703081 ttaatggaag tgtcagcgac attgccggtg tcgtgaatga gaaaggcaat gtattaggca 703141 tgatgcctca ccctgagcgc gcggtcgatg aactgcttgg aagcgccgac ggtcttaaat 703201 tgttccagtc tatcgtgaaa aattggaggg aaactcatgt cactactgct tgaaccaagt 703261 aaagaacaaa taaaagaaga gaaactgtat cagcaaatgg gtgtcagtga tgatgagttt 703321 gcattgatag aatccattct tggaagattg ccgaactaca cagaaatcgg aattttttct 703381 gtcatgtggt ctgagcattg cagctataaa aactcaaagc cgattctgcg taaattcccg 703441 acaagcggcg agcgtgtgct gcaggggccg ggggaaggcg ccggaatcgt tgatatcggt 703501 gataaccaag cggttgtgtt caaaattgaa tcacataacc acccatcagc tctcgagcct 703561 taccaaggcg ctgcgactgg cgtaggcgga attatccgtg atgtattctc aatgggtgca 703621 cgcccaatcg ctgtattgaa ctctcttcga tttggtgaac tgacttcacc ccgcgtgaag 703681 tacttgtttg aagaagtagt agcgggtatc gccggatacg gcaactgtat cggcatcccg 703741 acagtcggcg gagaagtgca gtttgacagc agctatgaag gaaatccgct cgtcaacgca 703801 atgtgcgtcg gtttaatcaa ccatgaagac atcaaaaaag gccaggcaaa gggtgtcggc 703861 aacacagtaa tgtacgtagg agcgaaaaca gggcgtgacg gcatccacgg cgctacgttt 703921 gcttctgaag aaatgtcaga ctcgtctgaa gaaaagcgtt ctgctgtcca agtcggcgat 703981 ccgtttatgg agaagctttt gcttgaagca tgtctggaag tcatccaatg cgacgcctta 704041 gtcggcattc aggatatggg agctgccggt ttaacaagct caagtgcaga aatggcaagt 704101 aaagccggtt ctggcattga aatgaatctt gacctgattc ctcagcgcga aacaggcatg 704161 accgcgtatg aaatgatgct ttctgaatca caagaacgga tgcttttggt tattgagcgc 704221 ggacgtgagc aggaaatcat cgatattttt gacaagtatg atcttgaagc ggtttctgtc 704281 ggacatgtga cagatgataa aatgcttcgc ctgacacata aaggagaggt tgtgtgcgag 704341 ctgcctgttg atgccttggc agaagaagca ccggtttacc ataagccttc tcaagagcct 704401 gcttactatc gcgagttttt ggaaacagac gttccggctc cgcaaattga agatgcgaat 704461 gaaatgctga aggcccttct tcagcagccg acgattgcga gtaaagagtg ggtttatgat 704521 cagtatgact acatggtgcg cacgaataca gttgtcgctc ctgggtctga tgctggtgtt 704581 ctcagaatcc gcggaacgaa aaaggcgctg gcgatgacga cagactgtaa cgcgcgttat 704641 ctctatcttg atcctgaagt cggagggaaa attgctgtcg ctgaagcagc gcgcaacatc 704701 atttgctcag gcgcagaacc gcttgcggtg acagataacc ttaacttcgg aaaccctgag 704761 aagccggaaa tcttctggca gatcgaaaaa gcggcagacg gcataagcga agcgtgcaat 704821 gttctcagca ctccggttat cggcggtaac gtatcgcttt ataacgaatc aaacggcacg 704881 gcgatctatc cgacaccagt tatcggcatg gtcggcctaa ttgaagatac agcgcacatt 704941 acaacacagc atttcaaaca agcaggagat ctcgtatacg tgatcggcga aacaaaacca 705001 gagtttgccg gaagcgagct gcaaaaaatg acagaaggcc gtatttacgg caaagcgccg 705061 caaatcgatc ttgatgtaga gctgtctcgt caaaaagcac tgcttgacgc gattaaaaaa 705121 ggcttcgttc aatctgcgca tgatgtgtct gaaggcggct taggcgtagc gattgcggaa 705181 agtgtcatga cgacggaaaa ccttggcgct aatgtgactg tagaagggga agcggcgtta 705241 ttattctctg aatctcaatc tcgcttcgtc gtttcagtga aaaaagaaca tcaagctgcg 705301 tttgaagcaa ctgtcaaaga tgcagttcat attggtgagg taacagctga cggaattctg 705361 gcgattcaaa accaagacgg acaacaaatg attcatgcgc aaacgaaaga gcttgaacgc 705421 gtatggaaag gagctatccc atgcttgctg aaatcaaagg cttaaatgaa gaatgcggcg 705481 tttttgggat ttggggacat gaagaagccc cgcaaatcac gtattacggt ctccacagcc 705541 ttcagcaccg aggacaggag ggtgctggca tcgtagcgac tgacggtgaa aagctgacgg 705601 ctcacaaagg ccaaggtctg atcactgaag tatttcaaaa cggcgaactc agcaaagtaa 705661 agggaaaagg cgctatcggg cacgttcggt acgcaacggc tggaggcggc ggatacgaaa 705721 atgttcagcc gctcctcttc cgttcccaaa acaacggcag cctggcgctt gctcataacg 705781 gaaatcttgt caacgccact cagctgaagc agcagctcga aaatcaaggg agcatctttc 705841 aaacctcttc ggatacagag gttttggctc acctgatcaa aagaagcgga cacttcacgc 705901 tgaaggatca aattaaaaac tcgctttcta tgctgaaagg cgcctacgcg ttcctgatca 705961 tgaccgaaac agaaatgatt gtcgcacttg atccaaacgg gctgagaccg ctatccatcg 706021 gcatgatggg cgacgcttat gtggtcgcat cagaaacatg cgcatttgac gtcgtcggcg 706081 caacgtacct tcgcgaggta gagccgggag aaatgctgat cattaatgat gaaggcatga 706141 aatcagagcg tttttccatg aatatcaatc gttccatttg cagcatggag tacatttatt 706201 tctccagacc agacagcaat attgacggta ttaatgtgca cagtgcccgt aaaaaccttg 706261 ggaaaatgct ggctcaggaa tccgcagttg aagctgacgt cgtaaccggg gttccggatt 706321 ccagtatttc agcggcgatc ggctatgcag aggcaacagg cattccgtat gagcttggct 706381 taatcaaaaa ccgttatgtt ggcagaacgt ttattcagcc gtcccaggct ctgcgtgagc 706441 aaggcgtcag aatgaagctg tctgcggtgc gcggggttgt agaaggcaaa cgcgtcgtga 706501 tggtggatga ctctatcgtg cgaggaacaa ctagccgccg gattgtcacg atgctaagag 706561 aagcgggtgc gacagaggtg catgtgaaaa tcagttcacc gccgatcgct catccgtgct 706621 tttacggcat tgacacttcc acacatgaag aactgatcgc gtcttcgcat tctgttgaag 706681 aaatccgtca ggaaatcgga gccgataccc tctcattttt gagtgtggaa gggctgctga 706741 aaggcatcgg cagaaaatac gatgactcga attgcggaca gtgtctcgct tgctttacag 706801 gaaaatatcc gactgaaatt taccaggata cagtgcttcc tcacgtaaaa gaagcagtat 706861 taaccaaata aaacttgaaa aatgacataa aggcagcgca gttcggctgc ctttctcttt 706921 ctgccctcgt tcggggagat attttgaaaa gcgccttaaa ggagtgaata ggatgtctga 706981 agcatataaa aacgcaggag ttgacatcga agccggatat gaagctgtaa aacgaatgaa 707041 aaaacacgtg gagcgcacga aacggcttgg cgttatgggc agccttggcg gttttggcgg 707101 catgtttgac ctgtctgagc tttcttatca aaaaccagtt ctcatttcgg gaacggacgg 707161 tgtcggcaca aaattaaagc tcgctttttc catggataag catgacacga ttggcgtgga 707221 tgctgttgca atgtgtgtca atgacgtgct ggcacaaggt gcagagccgc tgtttttcct 707281 cgattattta gcggttggca aagcggaccc agtgaaaatt gaacagattg tacaaggtgt 707341 tgcggaaggc tgtgagcagt caggttcagc cttagtcggc ggtgaaacgg ctgaaatgcc 707401 ggggctctat acagctgatg aatacgatat tgccggtttc tcagtcggag tggcagaaaa 707461 ggacgaaatc gtgactggag aaaaaattga agagggccat ctgttgatcg gcctcagctc 707521 cagcggcctt cacagcaacg gcttttccct tgtcagaaaa gtgcttctgg atgatgcgga 707581 gctggacctc gatacaacat atgagccgtt tgaacgcccg cttggcgagg aattgcttga 707641 accgacaagg atttacgtga agcctgtgct tgccgcggtc aaaagcggaa aaatcgacgg 707701 catggcgcac gtgacaggcg gaggatttat tgaaaatatt ccgcgtatgc ttccggaagg 707761 cttaagtgcg gaaattgatc atggctcatg gccgatcccg ccgatttttt ctttcttgca 707821 agagtacggc aagctaaagg aagaagacat gttcaacgtc tttaatatgg gtatcggttt 707881 tgttttggca gtcaaagaag agcatctgac agatgtgatc ggaacgcttg aaagccatgg 707941 cgaaaaagcc tatttaatcg ggcgtgtgaa aaaaggtgaa ggcgtcacat tcggcggtgc 708001 ggcactttca tgaaaaagtt tgcggtattt gcatcaggaa acggttcaaa cttcgaagcc 708061 atcgtcacgc gtttgaagga ggagaactgg gatgcgtcag cagcgctcct cgtttgcgac 708121 aaaccgcagg cgaaagtcat cgaacgggcg gaagcattcc acattccatc cttcgcattt 708181 gagccgaagt cttatgaaaa caaggctgca tttgaacaag ccatcattga acagcttcgt 708241 cttcacgagg ttgaattgat tgctcttgcc ggctatatga ggctgatcgg tgatacgctc 708301 cttcaagcat atgggggaaa aatcattaac attcacccat cgcttcttcc ggcgtttcct 708361 ggaatcgacg cagtcggaca ggcgttccgg gcgggtgtga aggtggccgg aatcaccgtg 708421 cattatgtcg atgaaggaat ggatacaggt ccgatcatcg ctcaaaaggc aatcgaaatt 708481 gatgaacatg atacattgga aacaatcgaa cagcgaattc acaagcttga gcataaatgg 708541 tatccgagtg tgattaaaca gctattagga ttaaataaca gaggtgaaaa ggcatgacca 708601 ttaaacgtgc attaatcagt gtttcagata aaacaaatct cgttcctttc gtaaaagaac 708661 tgacagagct tggcgttgaa gtcatctcca caggcggaac gaaaaagctt cttcaagaaa 708721 acggtgtgga tgtgatcgga atttctgaag tgacaggctt tcctgaaatt atggacggcc 708781 ggttaaaaac cctacacccg aatattcacg gcggccttct ggcggttcgc ggcaatgaag 708841 agcatatggc gcagatcaat gaacacggga ttcagccgat tgacctcgtt gtcgtcaacc 708901 tctatccatt taaagaaacg atttctaaag aagacgtcac gtatgaagaa gcgatcgaaa 708961 atatcgacat cggcggacct ggcatgctgc gcgcggcatc aaagaaccat caggatgtca 709021 cggttatcgt cgatccggcc gattacagcc cagtgctaaa tcaaatcaaa gaagaaggca 709081 gcgtatctct tcagaaaaaa cgcgagctcg cggcaaaagt attccgtcat actgcggcat 709141 atgatgcact gatcgctgac tatctgacaa atgttgtcgg tgaaaaagaa ccagagcaat 709201 tcactgtgac atttgagaaa aaacaatcgc ttcgctatgg agaaaacccg catcaggaag 709261 caactttcta tcaaacagct cttcctgtca aaggctccat tgcgcaagca gaacagcttc 709321 acggaaaaga gctttcttac aacaacatta aagacgcgga tgctgcagtt caaatcgttc 709381 gtgaattcac tgaaccggct gctgttgctg tgaagcatat gaacccgtgc ggcgtgggaa 709441 caggaaaaac gatcgcagaa gcgtttgaca gagcgtttga agcggataaa acatctatct 709501 tcggcggcat tatcgcgctg aaccgtgaag tggacaaggc aactgccgaa gcgcttcaca 709561 acattttctt agaaatcatc attgcgcctt cattcagcca agaagcgctc gacgtcctga 709621 ctgcgaagaa aaatctccgt ctgctgacgc ttgacgtatc cgccgctgtt caaaaggaaa 709681 aacagctgac atccgttcaa ggcgggctgc tgattcaaga tttagatatg cacggcttcg 709741 atgatgctga gattagcatt ccgacaaaaa gagagccgaa cgagcaagag tgggaagact 709801 tgaagcttgc ttggaaagtc gtgaagcatg tgaaatcaaa tgcgattgtt ctcgcgaagg 709861 acaacatgac agtcggcgtg ggagcaggcc aaatgaaccg cgtcggatcg gcaaaaatcg 709921 caatcgagca agcaggggaa aaagcgaagg gcagcgcgct cggttcggat gcatatttcc 709981 caatgccaga tactgtcgaa gaagcggcaa aagcgggcgt tacagccatc attcagccag 710041 gcggatcgat ccgagatgag gattccatca aaaaagcgga tgaatacggc attgccatgg 710101 tattcaccgg catcagacac ttcaaacatt aaggggatga aaacgacgtg aatgtattaa 710161 ttatcggtaa aggcggaaga gaacatacgc tggcgtggaa ggcagcgcaa agcagcctcg 710221 tcgagaatgt atttgccgct cccggaaatg acggcatggc agcttccgct cagcttgtaa 710281 acattgagga aagcgaccac gcagggcttg tctcatttgc aaaacaaaat caggtcggcc 710341 tgaccattgt cggccctgag gttcctttaa ttgaaggtct ggtggatgaa ttcgaaaaag 710401 cgggcttaca tgtgttcggt ccgtcaaaag ctgcggcgat catcgaagga agcaaacagt 710461 tcgctaagga tttaatgaag aaatacgaca ttccgaccgc agaatacgag acgtttacat 710521 cctttgatga ggcgaaggca tatgtgcagg aaaaaggtgc tccgattgtg ataaaagcag 710581 atggacttgc agctggaaaa ggcgttactg tggctatgac agaggaagaa gcaattgcgt 710641 gcttgcatga ctttcttgaa gatgaaaagt tcggtgatgc gagcgcgtcc gttgtcattg 710701 aagaatatct ttctggtgaa gaattttctc taatggcctt tgtcaaaggg gaaaaggtgt 710761 atccgatggt gattgcccag gatcacaagc gggcgtttga cggagacaaa ggcccgaata 710821 caggcggcat gggcgcctac tcgccagttc cgcaaatttc ggaagaaacg gtccgccatg 710881 ctgtagaaac gatcgttaag ccggctgcaa aagcaatggt acaagaaggc cgttccttca 710941 ctggcgtttt gtacgctgga ttgatgctta ctgaaaacgg ctcgaaggtc attgaattta 711001 atgcccgttt cggcgatccg gaaacacagg tcgtgcttcc gcgcatggaa tctgatctgg 711061 tacaggtgct tcttgatctt ttagatgata aggaagttga cttaagatgg aaggataccg 711121 cggcagtgag tgttgtgctt gcatcagaag ggtatccgga aagctatgca aaaggcacgc 711181 cgatcggcag ccttgcagca gaaactgagc aggtcgtggt cttccatgcc ggaacgaaag 711241 cagaaggtgg agagttcgtt acaaacgggg ggcgcgtcgc caatgtgacg gcttttgatg 711301 aaacgtttga agcggctaga gaccgagtgt acaaagcggt tgatgaaatt ttcaaaccgg 711361 gactcttttt cagaaaagac attggggcac gcgctttaaa ggctgcccaa aaataagtga 711421 ggaaaacccg cagaatagct gcgggttttt tgttatcaaa aagcgggatg gcagctagaa 711481 gaagaaagca caacgagcgt ggttggtttt ccatgggcca tcgaggtgtc aataaaatcc 711541 tcaagcgtat gtaccgattc agtcacgacc tttgtcacat agctgtacat ccccgtgatg 711601 cggtggtttt ctgctacatc aggatgcgat gttgcaaagg cggcgtagtg cttgcagctt 711661 ttcggctcca tgagaataaa agcggtgaca tgcttgttta gtttttcgta acagatattc 711721 gcgctgtagc cggtaatcac tcctttgtct tccagcttcc tgacacgctc cgccgcgctt 711781 ggcgagctga gtccgacaag ctttcccagc tcaaccatcg ttaatctgcc gtttcgctgc 711841 aaatgcgaga gaatctgaag gtctgtatcg tccatttgtc tggctccttt acatatttag 711901 gcgaatgaat gaaaattcct ttgatcgtaa ggtaatgctg ttgatttaac ttcattgtag 711961 catatggatg ccgtcttatt ttttctataa taaagccatc aatcagagag ggggcatcat 712021 gttgccagaa ttgcagcgct ctattacttg gatacaaggg acggcgttaa cgattggggc 712081 ggttttagga tgcgggatat taatcctgcc gtctgtcacc gcggacacgg ccggccccgc 712141 ttctttattt gtttgggtgt tcatgtcctt cttatccttt tttcttgtcg gcacgctggc 712201 ccggcttgtg aaaatagcgc ctagcgcggg aggaatcacg gcttatgtgc agctggcctt 712261 tcagaaaaaa gccggggcta ttttgggctg gatcatgtta gggtccgttc cgatcggcgt 712321 tcccatcatc gctttgactg gcgcgcatta cgtcagttac atcacagagg cggccgattg 712381 gcagattaca ttgattgctg gttgcatgct ggctatatct attttgcttc atatgagagg 712441 gattcaacta tcagcaaaca ttagtacact cgttatatgt gtcatcgtat ttctgcttgt 712501 cacttctatt gctgtgtcat tgccacacgt cacgatagca gaattcaagc cgtttcttcc 712561 gcatggctgg tctgccgctg gatctgtttc tgttatgatt tttttctctt ttgtaggctg 712621 ggaaatgatt accccgttgg ctgaggaatt tcatcgtcct gaaaaagatg tcccgctcag 712681 cttgtttttg gcagcgtctt gtgtggcggg gctgtatatc atgctgtcat ttgtgaccgt 712741 gggtactcat tcatatggag agaatggaga aattgcatcg cttgccatgc tcatttcaaa 712801 aggagcagga gaaagcggtg tatatgtcac ggtatgttta gcgctgttta ttacattcgc 712861 caccatccat gccaatattg ccggtttttc aagaatggtg tacgcattgg cgagagaggg 712921 gcacataccc gtattttttg gaaaactcag tgcgacaaaa cgtacgccta ttcgcgtttt 712981 gacagcgatg gccgcagtgt ttggcttagt gcttgcagcg catggtctgt ttcaaatcga 713041 tttgacgact ctgttgaaag ggccgagcgc ggcttttatc gcatcttaca tatgtacaat 713101 ggcggcagca ctgaaactgc tgggcaggag agatataggc tggtggatgg cgctcggggc 713161 atttgtggcg tgcgcggtga tttattcatt cagcggctgg gcactgcttt atccggcagt 713221 gctggcagct gcaggatatt tctatatgaa aacaaagggt gggcataaaa aaaagcttga 713281 tcacgttttg tgatcaagct tttccattta tccgttttga tgctcgttat ttccagaatc 713341 gctgtgttga aacatgtagg tcacaggaca gaagcgcaag attcccgaac ccgctttcat 713401 ggcccccata aagatgtaaa agagatgcat tctgcaccaa ggttttttcg taaactttgc 713461 actggcggct gacataatcg tcaatccgca ggcgattctg aacacggcat tgatgagact 713521 gatgtttggc ttcaaggaaa tccgctcctt ttacttaaaa aagtttttta atcgaacctt 713581 caaaaatttg taacgttttt atcgtgcgtg atgaggaagg atgtgatacc atgagtctaa 713641 tacatgtaaa ggagagtatg tgaatgtccg aacgcacctt taactggaaa aacaaagaca 713701 tcagggcaca ggttgatgtt gtagactcaa agctgcttcc aacgctcctt ttacggaatg 713761 ctctcgtctt aaatccatat gtaaaacaat ggctgaaaaa aaacatttgg atttatcagg 713821 accgcattgt ttatgtgggt catgaacttc cgaatagagc cgaagaaatt catacgattg 713881 attgtgaagg aaaatacatt gtgccaggtt atattgaacc gcacgcacat ccttttcaaa 713941 tatataatcc ccaaacactg gcggaatatg tgtctcaata cggaacaacg acattcgtga 714001 atgataactt atttttgctt ttgcaaagcg gaaaaaagaa agcgcttacg attttgaatg 714061 aactcaaaaa gcagcctgtc cagtattttt ggtggtcacg ctatgacctc cagaccgagg 714121 ttctgaacga ggaccacgtc cttccatttg acgtcagaaa acagtggatt gaacatccgg 714181 atgtgattca aggcggagaa atgaccggat ggcctcgcct ggtagatggt gatgatttaa 714241 tgctccactg tatgcaagct acaaagaaac agagaaaacg tattgaaggg cattttcccg 714301 gcgcttctga taaaacgctt acaaaaatga agctgttcgg tgcggattgt gatcatgaag 714361 cgatgacagg tgatgaagtg atgagaaggc tggaactggg ctattatgtt tcccttcgga 714421 actcttccat tcgccccgat gtaagaaaaa tcttgcaaga gctgcatgag aagggcttcc 714481 gctattatga ccacttcttt tacacgacag atggcgcaac cccgaatttc tataaaggcg 714541 gcatgacaaa cgagctgatt cgcattgcgt tagaagaagg cgtacctgca atcgacgcct 714601 acaatatggc atcatttaat atcgcaaagt attaccaaat ggatgattat ttaggagttg 714661 tcggaccggg cagactggca tcgctaaaca tactggaaga tccgttaaat ccgaatccag 714721 tgactgttct gtcaaaaggg accattctgc gtgaaaacgg ctgtgatttg aaggcgttta 714781 caaagacgga ctggcacaaa ggcggtcttg tcccgcttga gctttcatat gatatgacga 714841 tggatgactt gcagttttct atgccgatgg gcgtgaaaat gcggaatgcg gttattatgg 714901 agccatatat gattgagatc gacaattcga tggaacagct ctcgtttgac catgatgaaa 714961 gttatttgac gatgctcgac agacacggga aatggcgcgt caatacgatg ataaaagggt 715021 ttgcctcaag cgtgcaggga tttgtaagct cctttacgac gacgggcgac attgtcgcga 715081 ttggaaaaaa taaagcggat atgctgctcg ctttcgcccg catgaaagaa atcggaggag 715141 gaattgtttt agcggagaac ggaaacattc tgcatgaaat cccgcttgcg ctgtgcggct 715201 gcgcctcttc ggaagcgtat gaagacgtgc ttgagaagga acaaaagctg agagatcttt 715261 tgactgaaag aggctatgag ttttgcgatc ctatctatac gctgctcttt ttgcaaagta 715321 cgcaccttcc gtatatacgc attacgccaa gaggaatatt cgacgtcatg aaaaaaactg 715381 tactctttcc atcgataatg cgttaaaata taaaagagca gggagccgac atatgaaaaa 715441 atggatgaca gtttgcgcgc tgtgtttcgt gttttttctg ctggtatcct gccagcagaa 715501 ggatgctgtc ccggatactg caaagaagct gaaagctcct ttaacggggc taaagactga 715561 acagaaagtg actgaacgcc gccctgttgc tgttgtggtg aacaatcacc cgaaggcgag 715621 gccgcagtcg ggtctgtcta aagccgacat tgtcatagaa gcgctagccg aagggcaaat 715681 cacaagattt ctggccattt tccaaagcca gatgcctgaa actgtcggac ctgtgcggag 715741 cgcgcgggaa tatttcgtca ctctcagcaa tggctttgac agcatatttg tccatcacgg 715801 ctggagtccc ggcgccaaaa agcagctgga atccggagct gccgattata tgaacggatt 715861 ggattttgac ggaagcttat tttggagagc tgatttcagc aaaccgcccc acaattccta 715921 tacgtcttat gattacataa aaaaggcggc agaacaaaag ggttataagc tgaagcagga 715981 aacaaatccg ctgctgtttc aaacatcaga tgcaaaacct gcaaatgaat cttacaatgt 716041 tcgggtagat tatggaacaa ataacgttac aaatcttgtc gaatacaact atgataaaaa 716101 agctgaattt tatacaagaa gctctgatgg tgtcataacg acagaccggg aaaccggaaa 716161 gccggttgca atgcaaaata ttttcattgt tgaagccagc catcatatta ttgatcaaga 716221 tggaaggcgg gacatcgact tggaatcagg aggaaaaggt ctgttgtttc agcacggaaa 716281 cgtcattgaa acagactgga aacaagtgaa tggcagaatt gtgccggtaa aagacggcaa 716341 gtggcttccg tttgtgccag gaaagacttg gatcaatatc gtacctgatc ttgatgcggc 716401 ttccattagt aaaggagaag gtgtgtaacg atgcaaatcg ataaattacg cggcaaagag 716461 ctggaccagt tatttaactc gatcttatcg ctgaaagacc tggaggaatg ttaccgattc 716521 ttcgatgatc tatgcacaat taacgaaatt caatcgctgg ctcagcgcct tgaagtggcg 716581 cgcatgcttc gcgaaggaaa cacgtatcat aagattgaaa cagaaacagg cgcttccacg 716641 gctacgattt cccgtgtgaa acgctgctta aattacggaa atgacgctta tgaaatggcg 716701 cttgaccgtg tgaaggagac ggaaacagag tcttcttcca aataaaaaac cgccctgccg 716761 tctggcaagg gcggtttctt tatgaaacaa attgatggat caggttgtcg atattgatga 716821 tactgccatc ctctttccga tagacaacat gctccttgga aaaatgaatc ggcgaattaa 716881 tccctgctgc ggctgcaagg ttaaatagtc cctcgcgcaa tgaaataacg tagttgcaga 716941 cacgatgctg tttttcctca acgctcagtg ctttttgcaa tttcggatct gtcgtcgcca 717001 cacctgccgg acaggtgttg gtgtggcaga cgagagcgcg gatgcagcca acggaaaaca 717061 tcatgccgcg tgcgatgtta acaaagtcag cgccgagggc taaggcgacc gcgattttat 717121 caggagtcag gagctttccg gaagcaaaga ttttcagctg gctgcgcaag ccgtactgtt 717181 taagaagcgt gtccacaata ggcagcgctg tcataatcgg aaggccgact gtatccgcga 717241 gctcgtaaaa ggaagctccg gtaccgcctt cacttccgtc gatcgtgata aaatccggat 717301 gctttccgct tttctgcata tgagagaaaa gctcatgcaa ttcttcagga tgccctgcga 717361 ccagtttgat gccgactggc ttttgtccga catctctaag tttttcaata aagtcgagca 717421 tttcaggagg gtttgagaat tcataaaagc ggttcgggct gtcaatcgac tttccaggtt 717481 cgacattccg aatgtctgcc acttcctctg atactttggc gccgtccaca tggccgccgc 717541 gggttttcgc tccttgtgcc agctttagct caaacgcttt aatctggtca atcctgcttt 717601 ttcttttaaa ttcctcccac gaaaattccc cgtttctttt gcgcacgccg aataggcccg 717661 gtccgatttg gcaaatgata tcggcgccgc cctttaagtg atattcagac aatccccctt 717721 cacctgtatt catccaggtg ccgcctgcca gatggagccc ttttgagagc gccgtaacag 717781 cccgttctcc aagagaaccg tagctcatgg cagactggcc gactaagccc ttcacataaa 717841 atggcttctc gcatgtatgc tcgccaatca cctgtacatc atcaggatgg agaaaatacg 717901 ggtctgcctt gatatgttcg gcatgctcct tgcgtttgaa cagattgtca gcatccattt 717961 tatagatttg ggtttcaatt tttggcgttt gatttacatg catttcttcc ctttgttttg 718021 gaaacatagc gttacggata taatagccag gtttatcaaa atctcttaca gatccaaagc 718081 ccatcattct gcttttgtat ttgccggaga tgacggtttg ctcatattcc tttcgtgaaa 718141 atggctgctc ttcattgtca ttgctgtata aatactgtct gagctccggc ccgatttttt 718201 caaggatata ccgaaacctt ccgatgacgg gatagttgcg aagaattgag tgctcctgct 718261 gtttttcatc ctttatgtag atccaggcaa acaagacgat cgggatagcg atgatcccaa 718321 tgataaatgc gatgagtgct attatgatgg tttccatctc tcagcctccc tttttatgta 718381 accatttcca cagtagaaca ctttccaaac aatagcagaa ggaatctggt gaaaaatgtg 718441 tgctcctgcc gatacaggac tcaccatgca ggtactgcca tatgctctct ttttttatga 718501 aaaaagaatc aaaacacctt tttcagtgaa taacgagatt aacggctttt tccgtttttc 718561 cgcgctatgt gaatttgtta taatgtttaa atggtaacaa acgaatggag gaacgtatga 718621 cgtgtacgat gtaacggagt ggaagcatgt ctttaaactc gatccaaata aagatttgcc 718681 tgacgaacag ctggagattc tttgcgaatc aggaacggat gcggtcatta tcggaggaag 718741 cgatggtgtg acagaggata atgtcctgcg gatgatgtct aaggtaagac ggtttttggt 718801 gccgtgtgtc ctagaggtat cagcgattga agcgattgtt cccggctttg acttatattt 718861 tattccgagt gtattaaaca gcaaaaacgc ggattggatt gtcggaatgc accagaaagc 718921 catgaaggaa tacggagaac tgatgtctat ggaagaaatc gtggcggagg gctactgcat 718981 cgcaaatcca gattgcaaag ccgcggcact gactgaagcg gacgccgatc tgaatatgga 719041 tgatattgtc gcctatgcgc gtgtgtcgga gctgctgcaa ctgccgattt tttatttaga 719101 atacagcggc gtgcttggag acatagaagc tgtcaagaaa acgaaggctg tattggaaac 719161 gtccaccttg ttttacggcg gcggcatcaa ggatgcggaa acggccaagc agtacgcaga 719221 gcatgcggac gtgatcgttg taggcaatgc ggtgtatgaa gattttgaca gggctttgaa 719281 aacagtagcg gctgtgaaag gcgagtagta aattgtacgg atttggttta tgatagaacg 719341 tatgttttgt ataggcgggt gaacaaattt tgaattatat tagcaatcaa ttactaagcg 719401 gtttaaaccc cgttcagcag gaagcagtca aaacaacgga cgggcctctt ttgctgatgg 719461 cgggagcggg tagcggaaag acgcgtgtcc tgacccatag aattgcttat ttaatggcag 719521 aaaagcatgt ggcgccgtgg aacattctgg cgatcacatt tacaaataaa gcggcacgcg 719581 aaatgaaaga acgtgtggaa agcatcctcg gacccggcgc ggacgatatc tggatctcca 719641 cattccacag catgtgcgtg cggatcttgc gcagagatat cgaccggatt gggatcaacc 719701 gaaatttctc catccttgat acggctgacc agctttcagt gatcaagggg attttgaagg 719761 agcgcaatct tgatccgaag aagtttgacc cgagaagcat cctcggcacg atcagcagtg 719821 caaaaaacga attgaccgaa ccggaggaat tctctaaagt tgctggcggc tactacgatc 719881 aggtggtcag cgatgtatat gctgattatc agaagaagct attgaaaaac cagtcgctcg 719941 atttcgacga tttaattatg acgacgatta aactgtttga cagagtgcct gaagtgcttg 720001 aattttatca gcgcaaattc cagtacatcc acgttgatga gtatcaggat acgaacaggg 720061 cacaatacat gctcgttaag cagcttgccg agcgtttcca gaacctttgc gttgtggggg 720121 attctgatca gtcaatctac agatggcgcg gcgcggatat caccaacatt ctttcatttg 720181 aaaaagatta tccgaatgca agcgtgattt tgctagaaca aaactatcgt tcaacgaaac 720241 ggattttgcg cgcggctaac gaggtcatta aaaacaactc taaccgcaaa ccgaaaaatt 720301 tgtggacgga aaatgatgaa ggcatcaaga tttcctatta tcgcggtgat aatgagttcg 720361 gtgaaggaca gtttgtggcc ggcaaaattc atcagcttca cagcacaggc aagcggaagc 720421 tgtcggatat cgccatatta taccggacaa acgcgcagtc ccgtgtgatt gaggaaacgc 720481 ttctcaaagc gggcttgaac tataacattg tcggcggcac aaagttctat gacagaaaag 720541 aaattaaaga cattcttgcg tacctgcgcc tcgtatccaa tccggatgac gatatcagtt 720601 tcacgcgcat tgtcaatgtg ccgaagcgcg gagtcggcgc gacatcactt gaaaaaatcg 720661 cttcgtatgc ggccataaac ggcttgtcct ttttccaagc gattcagcag gttgatttta 720721 tcggcgtcag tgccaaagcg gcaaacgcgc ttgacagctt tagacagatg attgaaaacc 720781 tgaccaatat gcaggattac ttatccatta cagagctgac agaagaaatt cttgataaga 720841 cggaatacag agaaatgctg aaggctgaga aatcgatcga agcccaaagc cgtttagaaa 720901 atatcgacga gttcctgtct gttacgaaaa actttgaaca gaaaagtgaa gacaagacac 720961 tcgttgcgtt cctgacagac ttggcattga tcgcagatat tgatcagctc gatcagaagg 721021 aggaagagtc aggcggcaag gatgcgatca ccctgatgac actgcacgcc gcgaaaggac 721081 tggagtttcc ggttgttttc ttgatggggc ttgaagaagg cgtcttcccg catagccgtt 721141 cactcatgga ggaagcggaa atggaagaag aacgccgcct tgcgtacgtt gggattacaa 721201 gggcggaaca ggagctttat ctgaccaatg ctaaaatgcg caccttgttt ggccggacaa 721261 atatgaaccc ggaatctcgc ttcattgctg aaataccgga tgatttattg gaaaacctaa 721321 atgagaaaaa agaaacaaga gcgacgtctg cgagaaaaat gcagccgaga cgcggccctg 721381 tttcacgccc ggtatcctac gccagcaaaa caggcggcga caccttgaac tgggcagtcg 721441 gagataaggc gggccataaa aaatggggaa caggaactgt cgtcagcgtg aaaggcgaag 721501 gagaagggac agagcttgat attgccttcc cgagccctgt cggcgtgaaa cgcctgttag 721561 cagcatttgc tcctattgaa aagcagtaat tgaagaggaa aggaagaagc agatggacaa 721621 agaaacagcg aagcagcggg cagaagaact gcgccgcacc atcaacaagt atagctatga 721681 atattacacc ttagatgaac cgagcgtccc agatgccgaa tacgacagat tgatgcagga 721741 gctgatcgcg atcgaggagg agcacccaga cctcagaacg cctgactctc ctacgcagcg 721801 cgtcggcgga gccgtgcttg aagcgtttca gaaagtcacc cacggcacac cgatgctcag 721861 tctgggcaac gcctttaatg ctgatgatct tcgtgatttc gaccgccgtg tgcgccagtc 721921 cgtcggcgac gatgtggcgt ataatgtgga gctgaaaata gacggtcttg ctgtttctct 721981 ccgttatgaa gacggctatt ttgtcagagg ggccacaaga ggtgacggga cgacgggaga 722041 ggatatcacg gagaatctga agacgatccg caatatcccc cttaaaatga accgtgagct 722101 gtcgatcgaa gtgcgcggcg aggcgtatat gccgaagcgt tcgtttgaag cactcaatga 722161 ggaacggatt aaaaatgagg aagaaccgtt cgccaatccg cgaaatgccg cggcgggatc 722221 tctcagacag ctcgatccga aaattgcagc gaaacgaaac ctcgatatct tcgtctacag 722281 tatagcggag cttgacgaga tgggtgtaga gacgcaaagc caagggcttg attttctcga 722341 cgaactcgga tttaaaacga atcaggaacg aaaaaaatgc ggcagcatag aagaagtcat 722401 tacgctgatc gatgagcttc aggcgaagcg cgcggacctg ccgtacgaaa tagacggcat 722461 tgtcattaaa gtcgattctc tcgatcaaca ggaggagctc ggttttacgg cgaaaagccc 722521 gcgctgggcc atcgcgtata agtttcctgc tgaagaggtc gtgacgaagc ttctcgatat 722581 cgaattaaat gtcggcagaa cgggtgtgat tacgccgact gcgattcttg agccggtaaa 722641 agttgccggc acaacggtct caagagcatc ccttcataac gaagatttaa ttaaagagaa 722701 ggacattcgg attttggata aggttgtcgt caaaaaagcg ggcgatatca tcccggaagt 722761 tgtgaatgtc ctcgttgacc agcgcacagg agaagaaaag gaattcagca tgccgacgga 722821 atgtcctgaa tgcggcagtg aactcgtccg gatcgaagga gaagtggcgc ttcgctgcat 722881 taaccctgaa tgtccggcgc aaatccggga agggcttatc catttcgttt cccggaatgc 722941 catgaacatt gatgggctcg gcgaacgagt gatcacacag ctgtttgagg aaaaccttgt 723001 ccgcaatgtg gcagatttat ataagctgac gaaggaacga gtcatccagc tcgagcgcat 723061 gggcgaaaag tccactgaaa acctgatcag ctccatccaa aaatcaaaag aaaattcgtt 723121 agagcgcctg ctgtttgggc ttggcatccg ttttatcgga tcaaaggccg caaagacgct 723181 tgccatgcat tttgaaagct tggagaacct gaaaaaagcc tctaaagagg aacttctcgc 723241 ggtagatgaa atcggtgaaa aaatggctga tgctgtgatc acctattttc ataaagaaga 723301 aatgcttgaa ctcttgaatg aacttcagga gctgggcgta aacacgctct acaaaggccc 723361 gaaaaaagta aaagcagagg acagcgactc ttactttgct ggtaaaacaa ttgttctgac 723421 aggaaagctg gaagagctgt caagaaacga agccaaagcg caaatcgaag cgctgggcgg 723481 aaagctgact ggaagcgtca gcaaaaacac agacttagtc atcgccggag aagcggcggg 723541 aagcaagctg acaaaagcac aagagctgaa cattgaagtg tggaatgaag aacagttaat 723601 gggagagcta aagaaataag aggagtgttt tctattgaaa aagacgttgg cattggcggc 723661 aacggcggca gtattaatgc tgtctgcctg ctcgtcaggt ttcggggggg agaaggagga 723721 agagattacg caaaagacgg cgaaatcgtc agaaaaagcg attgtcccga aatataatat 723781 ctctgactcc tattacaaaa tggtgctgcc gtttaaggca ggcaaagcgc gcggcttaac 723841 aacggaacag ctgaatacaa ggctggacat tgacgaattt gaaacagggc tgatgcgcct 723901 tgcccaagat tctttctcaa ctgacgatta tctgttccaa gaaggacaat atttagatga 723961 ggatacagta ttaagctggc tggcacggaa aaaaacgggc tctgatttga aaaaagccga 724021 aaaagaagat aagaacttca aaaatgaagg cttgaacccg gcgctcccga gttctggttc 724081 aacagaagaa aagaacgaaa gcagcccaat ttatttagca tccatgcttg agcacgatta 724141 tttagtcaga aaagacaaga attctatcca gcttggcggc gtcatgatcg gactggcgtt 724201 aaactcagtg tattactatc gtgaaaaaac tggcgacccg caaaaagaag tggagattaa 724261 agacagcacg cttcgccagc agggagaaaa aattgcacag gaggttatta accgcctccg 724321 caaaaaagat aacttgaaga atgtgccgat taccgtggcg ctctacaagc aggcgtcaaa 724381 aacatcgatt gtgccgggga acttcatcgc caaaacagag gtcaaagcag gctctactga 724441 tatctcaaat tgggatgaca tcaatgaaaa atatgtattc tatccggcgg atacaaccac 724501 agcagaaaag tacccggatg acaccgaggt ctttaagcgg ttcaaaaact caattgaaga 724561 atatttcccg aactatacag gcgttgtcgg tacagcgctg tatgaaaatg atgaaatgaa 724621 gaaaatgaag attgacatac caatgcaatt ctacggaaaa agtgaagttg tcgcgtttac 724681 ccagttctta acgggtgaag tgatggacta ctactctaag agctcagttg atgtcgaagt 724741 caatatcacg tcctcagacg gacaggaagc ggtcattatc cgcaatgccg gagataaaga 724801 gccgactgtt cacatttatg actgatagaa aacccttgtg ccatattggc acaagggttt 724861 ttatgttaca attaacagga aaagggaaaa tattttcact tctgccgaaa cacaaatcaa 724921 ggggaggtat gttgatgctg gaaatcgtgt gaaaacaatc attatcaaat ctatagcaat 724981 gaaaggatgt tagacgtgca taaagatatc aaaaaaatat ttcatgaaga gcaggttttg 725041 gcagaagctg cagcgagata cggtttctca aaagatcagg tgcgttttct ggctgatgcg 725101 gaaaactatg tatatgaatg tatgaaagac aatcaacctt atattttaaa gattacccat 725161 acgattcgga gatcttctga ttatatgatg ggagagatgg aatggctccg tcaccttgca 725221 atagggggaa tttcagtagc caaaccgctc ccgtcgctga acggaaaaga cgtagaagca 725281 gtgccggacg gaaacggcgg gtcattttta ttgagagtgt atgagaaagc gccggggcaa 725341 aaagtggatg aatcggactg gaatgaaacg ctattttatg agcttggcag atacacaggc 725401 agcatgcaca gcctgacaaa aagctacaaa ttgagcaatc ccgctttcaa aagacaggaa 725461 tgggatgaag aggagcaatt aaagctgaga aaatatgtgc ctgaagatca gataaaggtg 725521 tttcagcaag ccgattcttt gatgaatgaa ctgcggaggc tcccgaaaag ccaggacaac 725581 tacggcttgg tgcatgcgga tctgcaccat ggcaatttta actgggatca tggcaaaatc 725641 acggcatttg attttgatga tatcggctac aactggtttg ttaacgatat tagcattctt 725701 ctctacaatg tcctgtggta tcctgttgtg ccatatgatg ataaagctgc gtttacagaa 725761 gaatttatga cgcattttat gaaagggtac tgggaggaaa atgagcttga ccctgcatgg 725821 ctgatgataa tacctgattt cctccgcctt cgccatatgc tgatttacgg attgctgcat 725881 cagatgtttg accttaacac aataggagaa gaggaaaaag aaatgctggc cggtttcaga 725941 agagatatag agaatggcac gccgattaca gcatttgatt tttcagcact ggtgtagata 726001 gaaaaagcca atgggattcc agtcccattg gcttttataa tgtatcacac ttcacgccga 726061 ctacgccttc aatggcttta atgtcatagt agacatcggt cgtgtatctg tttttatgga 726121 cgcggacctt cacttccata attggaaaat ccttttcgcc taggtcgtcg atccgaacgg 726181 agtgtgcttt gatatctctt cttttcattt cttttaaaat ctctgtcatt ttgtctttat 726241 cagaaagtga cattctgatg cggatgtctt tttcctgcag gcggtcgggg ccgatttttc 726301 tgaccaccca tgggagaaat tccacactga tcaggatgaa cagaagactg gcaaacgctt 726361 ctttataaaa accggctccc gtagcaagcc cgagccccgc tgccccccag atcatggccg 726421 atgtcgtcag gccggaaatg acatcattgc tttttcgcag gatgacaccg gcgccgataa 726481 acccgacgcc ggagatgatt tgtgccggca gacgaagcgg atccatcatg atgcggtagt 726541 atttagggaa atgatatgcc gcattaatac tgacgatcgt cagcatgcat gagctgactg 726601 cgatgacaat acaggttttt aatccgagcg gcttattttt taattcgcgt tcaagcccga 726661 tgaccatgcc aatcaatgtg gcaatgccca atttcaataa aatatcagga tcaatatacc 726721 agctcaacag caaacttccc ccttctctat ggtgttttta aataaatatg attttctcac 726781 agtatttata gcaaaacaag agcacaaaag ccaccaagct gcgcttgatg gcttattgct 726841 tactttttgc gttttaacag cttttccatg acaccgaata atcggtaaga ggcttttgca 726901 ggacgttttg tgatcatgct gacaatgatg ccggcaatca tactgagaat aaacccaggg 726961 atgatttcgt acacaccggt tgattttgcc aggccggttg taatccagat caacacggtc 727021 gcagccccga caatcatggc agcaagcgcg ccccattcgt tcattcgttt ccaatacaga 727081 ctgagcagaa tcgcaggccc gaaagctgaa ccgaagccgg cccaagcgta tccgaccaaa 727141 tcaagaatgg tgctgttcgg gttcaatgac aagagtaccg cgataacggc aatgactaag 727201 acggacaatc gcccgatcat gaccaattct ttatcagaag cttttcgtct gaaaaatgac 727261 cggtataaat cctctgttac agcacttgct gtgaccaaga gctgtgagga aatcgaactc 727321 atgatggcag ccaaaatagc tgacaataag aaccctgtaa ttaatgggtg gaacaagatt 727381 ttagagaaga taatgaaaat catctccgga tcttttacag caactccgaa tttatgggcg 727441 tatgcaacac cgattaaacc cgtcagcacg gaacctagaa ctgtaatgat catccagctc 727501 atgccgattc ggcgtgcagg ttttaaatct ttaatgtctt taatggccat aaatcggacg 727561 atgatatgag gctggccgta gtagcccaac ccccaggcta aataggaaat aatgctaatg 727621 acgctcgcgc ctttaaaaat atccaataaa tgtggattaa cagcgtcgat ttcatggaaa 727681 gtcggagcaa cgccgcccac atgggtaaaa gcaacgatcg gcacaagcac tagtgctgca 727741 aacatgatcg caccctgcac gaagtcagtc agactgacag caaggaaacc gccaaacagt 727801 gtgtataaca cgacaactgc ggtggtcaga aacaggccta atttgtaatc cgcaccaaaa 727861 gcagattcaa acagccgtcc gccagatacc ataccggaag aggtatacaa tgtgaaaaag 727921 atcatgatga tcaatgcaga tacgattttc agcagtgatg aagaatgctg gaatcgttta 727981 tcaaagaaat caggaattgt aatcgcatca tctgccgctt ctgtataagc acgcagcctt 728041 ggagccagca gcaagtaatt tgagtacgcc ccgattgtaa gacctaaagc aagccataag 728101 gtggacagcc ctgtcgcaaa catcgcgccg ggaacaccca tcagcatcca tccgctcata 728161 tcggccgcgc cggcagacaa agcagtaacg aatggtccga ggcctcttcc tccaagcatg 728221 taatcattga tgtcagtggt tttcttgaat gcataccagc cgattaacag catggcaata 728281 aagtaaattc ctaaagatat aataatttca atactcacgt tttaccctct cttcatttct 728341 aataatgttg catcacctct caaattgatg gtgccagtta agcagcctgg cgtaagtgca 728401 aaacaaaaga aattcttttg cgggtgcact tggtaactta acctaacaaa gtattcccgg 728461 ccattcaagc gatgaaacat tgatcataag ctggaaatac cgttgcaaac ctagaaggga 728521 ataaagaata aaacgctttc aaaaaataat taaagtaaaa atattcagaa aaatatttcg 728581 tttctccttc tcctcatttt agtataaaat atatagggta ttgtttcgaa aacacaggcc 728641 tgtctcaagg cgttttgttg ctttaaaggg cttgtttttg atatgatcag tattatatga 728701 cttaacggag aaatatgtgg aggtggatca tatgtcacga atttcaatag aagaagtaaa 728761 gcacgttgcg caccttgcaa gacttgcgat tactgaagaa gaagcaaaaa tgttcactga 728821 acagctcgac agtatcattt catttgccga ggagcttaat gaggttaaca cagacaatgt 728881 ggagcctaca actcacgtgc tgaaaatgaa aaatgtcatg agagaagatg aagcgggtaa 728941 aggtcttccg gttgaggatg tcatgaaaaa tgcgcctgac cataaagacg gctatattcg 729001 tgtgccatca attctggact aaaggaggga cacaagaatg tcattatttg atcataaaat 729061 cacagaatta aaacagctca tacataaaaa agagattaag atttctgatc tggttgatga 729121 atcttataaa cgcatccaag cggttgatga taaggtacaa gcctttttgg cattagatga 729181 agaaagagcg cgcgcatacg cgaaggagct tgatgaggcg gttgacggcc gttctgagca 729241 cggtcttctt ttcggtatgc cgatcggcgt aaaagataat atcgtaacaa aagggctgcg 729301 cacaacatgc tccagcaaaa ttctcgaaaa ctttgatccg atttacgatg ctactgtcgt 729361 tcagcgcctt caagacgctg aagcggtcac aatcggaaaa ctgaacatgg acgaattcgc 729421 catggggtca tctacagaaa actcagctta caagctgacg aaaaaccctt ggaacctgga 729481 tacagttccc ggcggttcaa gcggcggatc tgcagctgcg gttgctgcgg gagaagttcc 729541 gttttctctt ggatctgaca caggcggctc catccgtcag ccggcatctt tctgcggcgt 729601 tgtcggatta aaacctacat acggacgtgt atctcgttac ggcctggtcg catttgcgtc 729661 ttcattggac caaatcggac cgattacacg tacggttgag gataacgcgt ttttacttca 729721 agcgatttcc ggcgtagaca aaatggactc tacgagtgca aatgtggacg tgcctgattt 729781 tctttcttca ttaactggcg acatcaaagg actgaaaatc gccgttccga aagaatacct 729841 tggtgaaggt gtcggcaaag aagcgagaga atctgtcttg gcagcgctga aagtccttga 729901 aggtctcggc gctacatggg aagaagtgtc tcttccgcac agtaaatacg cgcttgcgac 729961 atattacctg ctgtcatctt ctgaagcgtc agcgaacctt gcacgctttg acggcatccg 730021 ctacggctac cgcacagaca acgcggataa cctgatcgac ctttacaagc aaacgcgcgc 730081 tgaaggtttc ggaaatgaag tcaaacgccg catcatgctc ggaacgtttg ctttaagctc 730141 aggctactac gatgcgtact acaaaaaagc gcaaaaagtg cgtacgttga ttaagaagga 730201 tttcgaggac gtatttgaaa aatatgatgt tattgttgga ccgactacac cgacacctgc 730261 gtttaaaatc ggtgaaaaca cgaaggatcc gctcacaatg tacgcaaacg atatcttaac 730321 gattccggtc aaccttgccg gcgtaccggg aatcagtgtg ccatgcggat tagcagacgg 730381 acttccgctc ggcctgcaaa tcatcggaaa acactttgat gaaagcactg tataccgcgt 730441 tgctcatgca tttgaacaag caacagacca tcataaagca aaacctgaac tgtaaggggt 730501 gaaaagaatt gaactttgaa acggtaatcg gacttgaagt ccacgttgag ttaaaaacaa 730561 aatcaaaaat tttctcaagc tctccaacgc cattcggcgc ggaggcgaat acgcagacaa 730621 gcgttattga cctcggatat ccgggcgtcc tgcctgttct gaacaaagaa gccgttgaat 730681 tcgcaatgaa agccgctatg gcgctcaact gtgagatcgc aacggatacg aagtttgacc 730741 gcaaaaacta tttctatcct gacaacccga aagcgtatca gatttctcaa tttgataagc 730801 caatcggcga aaacggctgg atcgaaattg aagtcggcgg caaaacaaaa cgcatcggca 730861 tcacgcgcct tcatcttgaa gaggatgccg gaaaactgac gcatacgggc gacggctatt 730921 ctcttgttga cttcaaccgt caaggaacgc cgcttgttga gatcgtatca gagccggaca 730981 tccgcacgcc ggaagaagcg tacgcatatc ttgaaaagct gaaatccatc atccaatata 731041 caggcgtttc tgactgtaaa atggaagaag gctcacttcg ctgtgacgcc aatatctctc 731101 ttcgtccgat cggccaagag gaattcggca caaaaacaga attgaaaaac ttgaactcct 731161 ttgcgtttgt tcaaaaaggc cttgagcatg aagaaaaacg ccaggagcag gttcttcttt 731221 ccggcggcgt catccagcaa gaaactcgcc gttatgatga agcaacgaag aaaaccattc 731281 ttatgcgtgt caaagaggga tctgacgact accgttactt cccagagcca gatctagtcg 731341 agctctacat tgatgatgaa tggaaggaac gcgtaaaagc aagcattcct gagcttccgg 731401 atgagcgccg caagcgttat atcgaagagc ttggcttgcc tgcatatgac gcaatggttc 731461 tgacgctgac aaaagaaatg gctgatttct tcgaagaaac cgttcaaaaa ggcgctgaag 731521 ctaaacaagc gtctaactgg ctgatgggtg aagtgtcagc ttacctaaac gcagaacaaa 731581 aagagcttgc cgatgttgcc ctgacacctg aaggccttgc cggcatgatc aaattgattg 731641 aaaaaggaac catttcttct aagatcgcga agaaagtgtt taaagaattg attgaaaaag 731701 gcggcgacgc tgagaagatt gtgaaagaga aaggccttgt tcagatttct gacgaaggcg 731761 tgcttctgaa gcttgtcact gaggcgcttg acaacaatcc tcaatcaatc gaagacttta 731821 aaaacggaaa agaccgcgcg atcggcttcc tagtcggaca gattatgaaa gcgtccaaag 731881 gacaagccaa cccgccgatg gtcaacaaaa ttctgcttga agaaattaaa aaacgctaat 731941 aaaaaagcag cccttagagg ctgctttttt tatggtcaaa ttgagataaa gacaagatga 732001 gggcccgaag cctttcaact tctttgtcgt tggttccggc caaattggac agcatgcctt 732061 taataatcgg cttgcgcggt ttatcctgag tcaattcttc ctcgataaca tcaagtgaca 732121 cggtgatatc ctcgggcagc gtgctgtttt ctttcacttt ctgaatgtcc tcaagcagct 732181 ggtcttttcc cgcaggcatc gggttaaaaa tgtcttttga tacaatcgga ttgagtgcag 732241 aacggctcag cccctgtaca agatcatcca gtctctcaat aataaaggct gagatttctt 732301 ctgcatcgat attaagctca ccgttaaata ccatcacgtt catataggaa tgcacaatgc 732361 ctcttgccat gatggacaga tctgcgacat accgctcgat tccttcgcca taggatacca 732421 gcaaggcgtt ccggtacagc ttatccgtct ccatggttac tttgtaaaag tattgcttga 732481 tttcttgatt ttccggaatg atattttcgg taagcaaaag aacgataaaa tctttatgat 732541 cgcgaaaatc ctcaaattga gcgccaattt gcttttttaa cacttcctta ggcggctttc 732601 cggcgagatc ttcttctata tttttcattt tgttcataga cataccgata taatattcac 732661 aggcagataa cagcagcgct tctttcgatt tgaagtgcaa ataaaaagcg cccttcgaaa 732721 tgccgcattc actggcgatt tcttggatcg tcgtagctgc gaatcctttt ttcgcaaata 732781 aacgaatgct ggtttttatg attctctctt ttttttcatt catgacgtgc ttccccttaa 732841 tccttgaaaa atttagtaaa attttctggt atatgagttg acgttgttgc gttataacgt 732901 ttagtattat atagaatgac cagtcagtca ataaaaaatg taatggagga tatgatgaac 732961 cacgttatta atttcgttct gaaaaacaaa ttcgccgtat ggctgatgac gattattgta 733021 acggcagccg gcttgtatgc gggtatgaat atgaagcaag agtctattcc tgacgtgaac 733081 atgccttact tgacgatcag cacgacatat ccgggtgcaa caccaagcca agtggctgat 733141 gaagtgacca aaccggttga acaagccgta cagaacttgg acggtgtcag cgttgtgacg 733201 tcgacgtcct atgaaaacgc atcgtcggtc atgattgaat atgattatga gaaagatatg 733261 gacaaagcga aaacagaagc agctgaagcg ttagaaaacg tcaacctgcc tgatgacgcg 733321 aaggatccgg agatttcacg ctacagcttg aactcattcc cgattctgac gctgagcgtg 733381 tccagtgata aagataatct gcaagagctg acgaaacaag tggaggacag cctcgtttct 733441 aagcttgaag gcatagaagg cgttgcgtcc gtccaagtat caggccagca ggtggaagag 733501 gttgaattct ctttcaaaga agacaaactg aaggaatacg gccttgatga agatacagtc 733561 aagcaagtga ttcaaggttc agatgtgaca actccgcttg gattgtacac attcggaaat 733621 gaagaaaaat ctgtcgtcgt cagcggcgat attgaaacaa ttaaagattt gaagaatatg 733681 agaatcccga cggcatctgc ttcaagtgca ggcagcagcg cagcatctca agcaggtgcg 733741 cagagtgctc aagcagccca aagcgcgcaa gcggcagcac aggtgcagca aagcgcaagc 733801 acagcagtgc cgacggtcaa gctttctgac attgctacaa ttaaagatgt gaaaaaagct 733861 gaatccgttt cacgcacaaa tggcaaagac agcatcggca tcaacatcgt caaagcaaac 733921 gatgcgaata cggtagaggt tgccgacgat gtcaaagctg agctgaaaaa gttcaaagaa 733981 gaccataaag gcttcaatta cagcgcaact ctcgacatgg cggagccgat cacacagtca 734041 gttgacacga tgttaagcaa agccatcttc ggtgctattt ttgcgattgt gattattctc 734101 ttattcttaa gagatatcaa atcaacatta atttctgttg tttcaattcc attatcattg 734161 ctgatcgcac tccttgtgct gcagcagctt gatatcacat tgaatattat gacgctcggc 734221 gcaatgaccg ttgccatcgg acgtgtagtc gatgactcca tcgttgtgat cgagaacatt 734281 taccgccgca tgagactcaa agatgagccg ctccgcggaa aagccttggt tcgtgaagcg 734341 acgaaggaaa tgtttaaacc gatcatgtca tcaacgattg tgacaatcgc ggtattcctg 734401 ccgctcgcac ttgtaggcgg acaaatcggt gaattgttta ttccatttgc cttaacgatt 734461 gtttttgcgc ttgccgcatc cctagtgatt tcaatcacgc ttgtgccgat gctcgcacac 734521 agcctgttca aaaaatcatt aaccggtgcg ccgattaaag cgaaagaaca caaacctggc 734581 agacttgcaa acatctataa aaaagtattg aactgggcgc tgagccacaa atggatcacg 734641 tctatcatcg cggttctgat gctccttgga agcttgttcc tcgtaccgtt aatcggtgcc 734701 agctacctgc cgtccgagga agaaaaaacg atgcagctca catacagccc agaaccgggt 734761 gaaacgaaaa aagaagccga aaatgaagct gaaaaagcgg aaaaaatcct gcttgaccgc 734821 aagcatgtcg atacggttca gtattcatta ggctctggca gcccgcttgc cggaggagat 734881 tctaacggtg cgttattcta tatcaaatat gaaagcgaca cacctgactt tgataaagaa 734941 aaagataacg ttctgaagga aatccaaaag caatctgacc gcggagaatg gaagtcacag 735001 gacttcagct cttcaggcaa taataacgaa ttaacatact atgtgtatgg cgattctgaa 735061 aacgatatta aagacacggt caaagacatt gaaaaaatca tgaaagatga aaaggatctg 735121 aaaaacgtaa attcaggcct ttccagcaca tatgatgagt acacatttgt cgctgaccaa 735181 gaaaaactaa gcaagctcgg tttaaccgcg tctcaaattt ctcaggcctt aatgtcacaa 735241 acatcgcaag aaccgctcac cactgtgaaa aaagacggca aagagcttga tgtgaacatt 735301 aagacagaaa aagacgagta taagagtgtg aaagatttag agaataaaaa gatcacttcc 735361 gcgactggcc aggaagtcaa aatcggcgat gtggcaaaag tgaaagaagg atcaacatca 735421 gataccgtgt caaaacgtga cggaaaagtc tatgcagatg tcacaggtga ggttacctct 735481 gacaacgtca cagccgtatc agctgctatc cagaagaaaa tcgataagct tgaccaccct 735541 gataacgtat cgattgacac aggcggcgta tcagcggata tcgctgattc cttcacgaag 735601 ctcggtttag cgatgctggc agcaatagcg atcgtttacc ttgtgctcgt gattaccttc 735661 ggcggagcac tagcgccatt tgcgattctg ttctcattgc cgttcacagt catcggtgcc 735721 ctggtcggac tttacgtatc aggtgaaacg atcagtctga acgccatgat cggtatgctc 735781 atgctgatcg gtatcgttgt cacgaatgcc attgtcttaa ttgaccgcgt gattcataag 735841 gaagcggaag gcctgtctac gagagaagcg ctcctggaag ccggctctac acgactccgt 735901 ccgatcctga tgacagccat tgcgacaatc ggcgccttga ttccattagc cctcggcttc 735961 gaaggcggaa gccaggtcat ttcaaaagga ctcggcgtaa cggttatcgg cggtttaatc 736021 agttcaacgc ttctgacgct cctgatcgtg ccaatcgtat atgaagtatt ggcgaagttc 736081 cgcaagaaaa aaccgggaac ggaagaagag taaaaaacaa aaagcctcag ctctgctgag 736141 gctttcagct tgttgaaaaa ccctcgcatt cgttgtcagg tctgcgcgtc ggtgctcacg 736201 aattctacat tcgctccgct ccaatgctcc cccttcctag actacaaggg ttttcaatca 736261 agctgaaaga atgttaagga tgacaaaagc tcaaaacaag aatcagtttt gagcttttgt 736321 gcgttttcac ctgtaagatt atgtacattt tgttgcgatt tttttaactc atagtataat 736381 taaaggttgt tagtgtaaaa atggatcgga tactcttaag taggatgatg agataatgaa 736441 acgtgcacgc ataatataca atccgacttc aggacgggag atctttaaaa agcatcttgc 736501 ccaggtcctg caaaaatttg aacaagccgg ctatgaaacc tccacccatg cgacgacatg 736561 cgcaggagac gctacacacg ctgccaagga agcggcattg cgtgagtttg acctgatcat 736621 tgcggcaggc ggagacggaa cgatcaacga ggtcgtcaac gggcttgcgc ctttagacaa 736681 tcgtccgaca ctcggtgtga ttcctgtcgg cacaacgaac gacttcgcca gagcgctcgg 736741 aatcccacgc gaggatattt taaaagcggc agatacggtc attaacggcg ttgcccgccc 736801 gattgatatc ggacaggtca acggccagta ttttatcaat atcgccggcg gaggccgtct 736861 gacggagctg acgtacgacg tgccaagcaa actgaaaaca atgctcggcc agcttgctta 736921 ttatttaaaa ggaatggaaa tgctgccttc acttcgtccg acagaagtcg agattgaata 736981 tgacggcaag ctgtttcaag gtgaaatcat gctgtttttg gtcacgctga caaactccgt 737041 cggcgggttc gaaaagctcg cgccggattc cagcctgaat gacggcatgt ttgatttgat 737101 gatactaaag aaagcaaacc ttgctgaatt tatcagggtc gccacgatgg cgcttcgcgg 737161 agaacacatc aacgaccagc acattattta tacaaaagcg aaccgcgtga aagtcaatgt 737221 atcagaaaag atgcagctga acctggacgg cgagtacggc ggcatgctgc cgggcgaatt 737281 cgtgaatctg taccggcaca ttcacgtcgt catgccgaag gagaaagcgg aacagttgga 737341 tgactaaaac ttggcttggt aagccaagct cagaatgttg acaaaatcct aaaacagttt 737401 tcgttttagg attttgtcat cttttcagcg tgattgaaaa cctttgaagt ctaggaaggg 737461 cgagcatcgg agcacagcga atgttgaatt cgtgagcacc gaagcacagg cctgacaacg 737521 aatgcgaagg tttgcctaca cgctgaaact tggcttgaat aggccaagtt tttctttcgc 737581 ttaaaactag aggtgattat agatgaaaat gaaaccccca gtagaaaaaa atgaatacta 737641 cgatgtgaca tttgaggatt tgacacatga aggagcgggc gtcgcaaagg tccaaggctt 737701 cccgatcttt gtgccgaatg ccctacccga ggaaaaagcc caaatcaaag tgacacgcgt 737761 caaaaaaggg ttcgccttcg gccgcctgat tgagctgaag gaagaaagcc cgcatagaac 737821 ggacgcccca tgcccgattt acaaacaatg cggaggctgc cagcttcagc acatgaccta 737881 cgaaggccag ctcctgttta aacagaaaca agtcaaagac gtcttagaac gcatcggcaa 737941 gctggacctt tcaaaagtca ccgtgcaccc gacactcggc atggaagacc cgtggaacta 738001 cagaaacaaa gcacaggtgc cggtaggaga acgggaaggc ggactcgtcg cgggattcta 738061 tcagcaaaga agccatgaca tcatcgacat gagcgcctgc ctgatccagc aatccaaaaa 738121 cgacgaagcc gttcaagctg tcaaagacat ttgcgcaaac tacggtgtca aagcctacaa 738181 cgaagaacgc cacaaaggct ggctccgcca catcatggtc agatacggcg ttgttacggg 738241 cgaaatgatg atcgtcttca tcacaagaac aagcgacttc ccgcacaaag cgaagatcat 738301 cgaagacatc acagcgcaat tcccgcacgt caaatccatc gtgcaaaaca tcaacccaaa 738361 caaaacaaac gtcatttttg gcaacgaaac aaacgtcatc tggggcgaag aatacatcta 738421 cgacctcatc ggagacgtca aattcgccat ctccgccaga tcgttttatc aggtcaaccc 738481 agagcaaaca aaagtgctct acgacaaagc gcttgagtac gctgagcttc aaggggaaga 738541 aaccgtcatc gacgcttact gcggcatcgg aacgatttct ctcttcctgg caaagcaggc 738601 gaaaaaagtg tacggtgtag agattgtgcc ggaagcaatt gaggacgcga agcgaaacgc 738661 cgaattaaac ggcaacacaa acgcagagtt tgctgttgga gaagcggaaa ccgtgattcc 738721 aaagtggtac gaagaaggca ttacagctga tacgctggtc gtcgacccgc caagaaaagg 738781 ctgcgacgaa gccctcctgc ggacaattgt ggagatgaag ccgaagcggg tagtgtatgt 738841 gtcctgtaat cctggcacgc ttgcgagaga tttgcgggtg cttgaggatg gcgggtacgt 738901 gacgcgcgaa gtgcagcctg tggatatgtt tccgcatacg aatcatgtgg agtgctgtgt 738961 gttgataaaa ttaaaagaat aaatagtcaa aaatctatgc tgatggaact gttggttctc 739021 taaaacgata attgatttca atggttccat ttgcatgtac ttctatttca tctactaaca 739081 aatgaagcat ttcgggggta agtgtacctt ccttcatgaa tttatctaag ctctttttaa 739141 aatcaattat ttctttttca atcttttgaa attctaggtc cttagatagt tggtgaaggg 739201 tagtttcaaa atttgaaata tcttcattgg tgatatttat ggctaattgg taatcttctt 739261 tagatataac accattagca agagagataa ctaaattgga tttatctctc tttttatcgt 739321 ttaatttttc attaatttcg attatcttag attcgatttt ttctttgtac tttaacgctt 739381 tttcacttaa ttctttaaaa taattttcct tactgaattt caaatatatc ttatttaggt 739441 tggttattac tttatcagtt aaatctattt cacttacgta atgatcacta catgctttta 739501 aaccatgttt attataactt ccacaaacat aaccttttcg attcttttta aaatgcattg 739561 acctcctgca atctttgcaa accgcagtat ttgtaaagag atgtacttca gcttgaggtc 739621 tccttctttt tctagttatt aaaatctctt gtacaataag aaagtcttct aaaggtatga 739681 ttggttcgtg gcttttttca ataattattt ggttttctag gttaactgac cttcttcttt 739741 tactggtaac actcggtcta tattctctac attgttgtag tgtcccagta tagtgaggat 739801 tttcgagaat ttttcttatt gaagatccgt gccatttgtc agtagcgttc tttttgcggg 739861 caagctgcga gggactagtg accccttcgt tatacaatcc ccttgctatt gcatcaaagc 739921 cttttccagc aatatattct gaaaagattc taatatttac tattttctct gcgtttgctg 739981 aatttgagag agatatgatt gtagaacgaa ctcaagaagg taaaatgttg gccaagcaga 740041 atccggattt ccgagaagga agacccaaaa agttcacaaa gcagcaaatc aatcatgcat 740101 taacattact agaaaatcat tcgtataaac aagttgaaga tatgactggg atatcagttt 740161 ctacacttgt aagagctaaa aagaagaaag ctgctgaagc tataaatgga taaatattgt 740221 gaattaatta ttcaatatct tgagaaattt ttataaaagt aatcaaaagt ttaatggggg 740281 aaacgaaatg gcgctcattg atttagaaga taaaattgct gaaatagtga atcgagaaga 740341 tcattcagat ttcttgtatg aattactcgg tgtatatgat gttccacgag ctacaattac 740401 gcgcttgaaa aaaggaaatc aaaaccttac aaaacgggtt ggtgaagtac acttaaagaa 740461 taaggtgtgg tttaaggagg ctaagaaagg aaagctcttt gacgccctta ttgatataga 740521 acaacaagtt gaatatcttt cagctaagcc acgatattta ttagttactg actatgatgg 740581 agtattagcg aaagatacaa aaacattaga ggctcttgat gttaaatttg aagaacttcc 740641 tcagtatttc gatttcttcc ttgcttggaa aggtattgag aaagtagagt ttgaaaagga 740701 aaaccccgct gatattaaag cagccgaacg ttttgcacgg atatatgatg tacttcgtaa 740761 agaaaacaat attattgaga ctaatagagg gttagattta tttcttattc gtttactgtt 740821 ttgttttttc gcagaagata ctgacatctt caaacgaaat agttttacga atttaattaa 740881 gactttgact gaagaagatg gttcaaatct aaataaatta tttgctgatt tatttatcgt 740941 gttagataaa aatgaacgag acgatgttcc atcttattta aaagagtttc cgtatgtaaa 741001 tggccagttg tttactgaac cacatacaga gttggaattt tctgccaaat ccagaaagtt 741061 aattattgag tgcggtgaat tattaaactg ggctaaaatc aatcctgata tctttggttc 741121 aatgattcaa gctgttgctt ctgaagaaag ccgtagttat ttaggtatgc actacacaag 741181 tgtccccaat ataatgaagg ttattaaacc gcttttccta gataaactta atcagtcttt 741241 tttagatgca tacgatgatt atacaaaact tgaaaatctt ctaacacgaa tcggcaaaat 741301 taaattcttt gatcctgcat gtggttcagg gaactttttg attattacct acaaagaatt 741361 acggcgtatg gaaatcaata ttataaaacg acttcaagaa ctcttgggag agtatcttta 741421 tgtaccttca gtaactttat ctcaatttta cggaatagag attgaagatt ttgcacatga 741481 cgttgcaaaa ttatcacttt ggattgctga acatcaaatg aatgaagaat taaaaaatga 741541 agttcataat gcagtacgcc caacgttacc acttcataca gcaggggata ttcgttgtgc 741601 aaatgctatt agggttgagt ggactgaggt ttgtcccgca caaggatctg aagaagtata 741661 tgtttttggt aatccaccgt atcttggttc aaaaaaacaa aacaaagaac ataaatctga 741721 tatgttatca atttttggaa aagtcaagaa tggtaaaatg cttgattata tttctgcttg 741781 gttttacttt ggtgctaaat acgcttcaac tacaaatgca aaagttgcct ttgtatcaac 741841 aaattcagtt actcaagggg aacaggtttc tatcttatgg aatgagttat tcaagtttgg 741901 aattcaaatc aattttgcct ataaatcttt taaatgggcg aataatgcta aaaataatgc 741961 tgcggtaatt gttgtgattg taggttttgg cccgttagat accaaagtaa acaagtattt 742021 atttgttgat gaaacgaaaa agctagtttc taacattagt ccctatttaa ctgatggtga 742081 aaatattctt gtttcttcta ggacgaagcc aatttcagac ttacccaaac tgcattttgg 742141 gaacatgcct aatgatggcg gaggattact ctttaccatt acggaatata cagacgcaat 742201 caataagtat cctgaattag ttccctattt taaaaagttt ataggttcag tagagtttat 742261 taatggtggt ttacggtatt gtttatggct taatgaagca aaatatgaaa aaataaagtc 742321 taatcctcta atacaagaaa gaatctcaat ttcaaaaaat cacagggaaa aatcaacaga 742381 taaaggaacg aataaacttg cattaactcc gtggaagttt agagatactc atgaaacaac 742441 taattattcc attgttgttc catctgtgtc ttctgaaaat agattttata ttccaatggg 742501 attagcaggt gcagatacaa ttttgtcaaa tctaatttat gtaatttacg atgcagaaat 742561 ttaccttcta ggcattttga tgtcacggat gcatatgact tgggtaaaag ctgtagccgg 742621 aagattaaaa actgactata ggtactctgc aggtttatgt tataacactt tccctattcc 742681 tgaattatca acaagaagga agaatgaaat tgaagaagca attcttgaaa ttcttgatct 742741 tcgtgaagag cagggtggta cattagcaga gctttataac ccttcaacaa tgccaattga 742801 attaaaagta gcacatgaaa agttggatgg aattgtagaa agagcgtatc gtcaaaaaca 742861 atttgaatct gatgaagaac gcttagaagt attgcttaaa ttgtatcaag aaatgacaga 742921 acggtaggtg taaggtgtat ggaaaatata attgaaatta attataacca aactggtaaa 742981 agtaagaaaa caaatgaata cggtatgcgt gaaatgcagg caagagcttt tgaaaaacgt 743041 aactcacaat atctcttagt taaagcaccg ccagcttctg ggaaatctag agctttaatg 743101 tttatcggtt tggataagct cataaatcaa ggtttgagga aagtgattgt tgctgtacct 743161 gaacgctcta taggttcttc atttaaaaat acggatttaa aaagttatgg tttctttgaa 743221 aattggaaag ttgatcctag aaataattta actgttggcg gagataactc taaggttaaa 743281 tcttttgttc gttttatgga atcggacgat caggtgttaa tatgtacgca ctctactttg 743341 cgatttgcgt ttgaaaaaat tgatgataaa gcatttgata attgtttact tgcaatagat 743401 gaatttcacc atgtatcggc agatgtcaat tctcgattag gtgaattgtt aagaagtatt 743461 attcataatt catcagcaca tattgtagcg atgactgggt cgtatttccg tggagattct 743521 gtaccaattt tattaccaga agatgaggaa ttatttgaca aggtaactta ttcctattat 743581 gaacaacttg atggatatga atatctaaag ggatttggta taggatatca cttctatcaa 743641 ggccagtaca catcagctat taatgaagta ttggatacaa ataagaaaac aatcgttcat 743701 attccaaatg taaactcagg ggaatcgaca aaggataagt acgatgaagt tggtaagata 743761 cttgatatga ttggtgaagt tgaatatcaa gatgatgata ctggaattat ttatgttaag 743821 cgacattctg acggtaaaac attgaaaatt gcagatttag tagatgacca agttggaaga 743881 gaaaatgtcg ttgcgtattt gcgtaatatt gaagccctag acgatttaga tataattatt 743941 gctcttggta tggcgaaaga gggctttgac tggccgtttt gtgaacatac tttgacagtt 744001 ggttatcgtg gctcacttac agaaatagta caaataattg ggcgctgtac acgtgatagt 744061 tacaataaaa cctatgctca atttaccaac ctaatcgcaa tgcctgatgc aaaggatgaa 744121 gtagtgactt atacagtgaa tacaatgctt aaagctattt ctgcctcact tttgatggag 744181 caggtcctta cacctgactt taaatttaaa cgtagaagaa atgaaagtga aaaatcttct 744241 actacaggag aattattcgt taagggattg aaagaaccat caacagaaaa tgtcaaaaag 744301 attattgaaa atgatattaa tgatttaaaa gcaaaaatca tgcaagattc acaagtccaa 744361 aaaacattta gtggagaagt agatcccaaa gtattgaaca aagtgttgat tccgaaagtt 744421 attcaaaaag tatatccaaa tttatcagat gaggaaattg aggaagttag acagcacgtt 744481 gttctagata cagttatgaa aggtgctaag tctgaagttg taggaagtaa agaatttata 744541 agaatggcag ataagtttat aaacattgag gatttagata tcaatctgat tgattccatc 744601 aatccgttcc aaaaagcatt tgaggttcta tcgaaagaat tgaactcacc agtgctaaaa 744661 ctgattcagg aaactattga tgcaaaacgt attaattttg atgaagatga actagtattc 744721 atatggccaa aggtttagga attttatcgt tcaactggta gaagacctga ttcaaaatct 744781 gaagacccac ttgaaaggcg tatgggtgaa gctgtattat acatgcaaga gcttaggagg 744841 aaacgtgaaa atggcaagta atagatacca ttctattaat gaaatcatgg aaagtcagct 744901 gttttaccaa atcacaacac cacctaagaa aacacaaaaa gcccagtatg atcctgaagt 744961 tgaaaagttt ttggagatta ttgaattcgt caaagaaaat gggcgagaac cccaaaaagt 745021 ccctactgat ttaactgaaa gaagtttagc aagtcgatta attgggattc ggaaagatcc 745081 tgatcgtatg gaatatttga aagagtatga tgaaattgga ttacttgaag taagatcgaa 745141 ggaactaaca attcctaaaa tttcttcaat tgatgatatt ctaaaaagtg gcttatctgc 745201 attattaggt gataatttaa ataatgatat aactaggtca atttttgata caagttcact 745261 tcaaaaggtt acgacaatgc ctgaatacgt tgcaaagcgt aaaaaaataa aagattttgg 745321 aaagtttgaa gagctattca agaagtgcca caaggaaatt acagagggta aacgaaaaat 745381 tttaactttc aaaaatgaac aagacataca gtcaaatagt ttttatatat taaaaggagt 745441 tcttctttat gttgaagatg tgggagaacg taaaaaagca aagggaaaaa ccaatgctag 745501 acttcgatgt atatttgaaa atggaacgga atcagatatg ttactacgtt ccttatcagc 745561 ggagttatat aaacatggta gacgtgtgac cgacaatgaa gatacattgt tggataatgt 745621 tagagaagat gatgtttcga ctggctttat ttacgtacta aaatctttga gtacagatcc 745681 gcaaattagt tccattaaga atttatataa gatcggtttt acaactggtt cagtagaaaa 745741 tagaatcagg aatgcagaaa atcaatcaac ttatctttat gctccagtag aaattgtaac 745801 cacatatcaa gtgttcaata tgaatgctag caaatttgag acggcaatcc atcatgcgct 745861 agcaaataat aatttggatg tttctatttt gggggcaaat ggaaagatgt tagttcctaa 745921 agagtggttc gttgtcacac ttgaagattt acaagctgta atagatgaga ttgtgatgat 745981 ggttcatctt tatgactaaa ttagtatatt aggattttag tattaataat aattttatag 746041 tagactatga aaaaatttga tgccataaca ataacttgtt ccgctttgga gtttgtcaca 746101 attgtagaat tatgtgttgc gagtattaat aggaaggggt tgagcgaccg caaaaaaaat 746161 tttcggtgct gtccgcaaaa gggagtttgg gtgttttgcg ttatatttgg ttgtgtgaag 746221 gttagcggaa actcaattcg tgaagttagg attgcggtta ttacgactga gtagtttcgt 746281 catactcttt tagcagtttt tctgtcttat gcatttcttt gagcatcgga ttcatgtagt 746341 cgttagctga ttctagatat gctctcgtca gagtgtctag tttatttcta actttagaga 746401 ggtcttcttc gaattttcca tccgatgatt gaaggataaa ttcttttgcc tcttcatatc 746461 tttttaatat gtttttcacc attggagttg gattcttttg atttattgtt tttattacag 746521 tgattgttaa atttatttgt tttattaatt cttttcttac tgtcaaggtg atgctccttt 746581 taaatctcta ttctatttga gagttgctat atctgtttaa tggtttgata gactactcat 746641 ctttataatt tagagcaatt tttacaactt gttccgctgt gtaatcttca ttgctccaga 746701 aaattaaatc acttggtgcc ggataaggaa catttttctc taataaatcg agatattcac 746761 tgactttctc atcatctaat gttgggttca ttaattcctt tacaagaaag atcaactctt 746821 cttttgtcag tttatccatt gtttgccctc caatagattg tatctccatt gattttacaa 746881 atgactttat ttcttctgat aatgttatag gttgtttgca taatgataga taattgtctt 746941 gagaaaagtt agtctcatta tagagtttat taattgtatt tataacaata tattcatatg 747001 gaaaacctct aaaatatctt tattttagat tggtttataa aaaatagctc agcagagtag 747061 ggctgagcca ttttttaatt atagaccgag gtaactaatt acaaattctt tatcatcctc 747121 atcttcaggc aaaataccaa ggtttttata ttcccatatt gcgattcttt catatccatc 747181 taattctgag gctaaaatat catcataatt ataatctaat tggaattctc cgctacgatc 747241 caatgttagt gtaaggttag tccaaacatc atcgttatta tttctgtgtt cagttcttaa 747301 ttcttcaaaa agttctctta gttctcttaa caacgtcttg aaaatatcct tgcttacgtt 747361 gtaatggcta ggtatatctt gtgaataaat aatttgatta ttttctggtg ttctgaaatg 747421 aaaaagaacc attgtggaat catctaatac ttctgcataa agatatatct ttgtccattc 747481 accaggtatg atgtcattga gtttttctcc aataagttga tacaaatctt gcatcttcct 747541 agtttccatt cttctaaccc ccaggctgat ttttaataga gacgcttatt tcttttctgc 747601 tcccaatttt gtaggttaca tcgaaatatg atggtctaag tgaatcccca gaatagactg 747661 gttctatttg aactgctact tttttaggtg gttttttgct tagggctttt gcccactcct 747721 gctccatctc ataccatttc ccaccgctcc tattaatctg agaattcatc ggcacgatat 747781 tgtcaaactg gcctgagcct ttgaattggg tggcgattaa atggccgccg tcatcgtcag 747841 gctttcggtc ctggggcttt ccagcattcg tttgtgcata ttggtttcgt ttcgcttctc 747901 ccagctgcaa gtctgctttg acacttgtaa ttctaccata gttgtcagtc gtgtacgtgt 747961 agccttcttt tgttttgtag atgatattag gcttcagcac tttctttctg ctccatcttg 748021 cgaaatgctc gccgtatttg acggttaccg gcggtacatg tggcgctgga gttcgtcttc 748081 cgcttgatga cgttccgtat ggtttcggca ggatgacctt ggcgaatttt tgcagtcctt 748141 ctttaagcgt gaccccgttg actgcgttgt aaggaacgcc tgccggcact aaatcatgac 748201 ggggatgata cgggagaata tccgcaagtg tgagatctcc gatttgattt aacttggttt 748261 tgacgtgttt ttttgatact tcaatgcctg tgtttacttt ttgtttgatg tgatcaacgg 748321 tttgttttga gactgttatg gctttttggg ctgttgctga tttgcttgct gctgttttga 748381 ctttggtcgt cactttggcg gctgtgccag tttttgagac ggctcctacg ccttttgtgc 748441 cgacaattga tgtgacaaca gtgccaaccg catatgacac ccatcttgct cttgagtagg 748501 tgtcaccatt caccatgtct ttttgatacg attcttcgat tgccgctgaa atggcttcat 748561 acgttttgat cgggtgagcc atcgctccgg taatcgcttc aacggttcct cccggatctg 748621 tgaccatatc ccacaggcct acgaccgcgt ctttcccgga atcataaagg ccgacggcaa 748681 cccctttgaa gcctgcttca agctcacgcg tgttttcaat ttgggtgaag tatctctgtt 748741 gttcagctgt cagattttca tagccgatcg tttttgccat ttcgtagaat tcatcggcat 748801 ctgcataatc gtagtttttc agtctttctt tcagtttctc aatctcgcgt tccttcgctt 748861 cctctttctt aatcttcaag taagcctcag tccgcttttc aatgtcgcct tttttcttat 748921 gtatgtcact ctcacggtac gccttggcgt tgtagtggat gggtgtggcg tttttgcctt 748981 tacccgttgc ttcttggagc ttttggaagt cggatttgat gaattgttcg tttggttcag 749041 acagggcgta ttctgttttc aggtcttcgt ccaaggcgtc caatttttcc agtgtttttt 749101 tgcgtttgtc gttggcatcg gccagctcgt ctttgaaggt ttctgttgaa aacaggtcga 749161 gcgggaggat gtcgtcgata tcgtttagga tgtctttcat cgcttttttc tgttcggaca 749221 tgatggattt agatttttta ttggcatttg ccagttcgtg ctccaggaag gattcttcga 749281 tgtatgcgtc tgagaggcct ttgtcttcgg cggctccggc gatgctgttg aaaaatgcga 749341 ttttcatgtc gatgtagtcg atccactggt cggcgacgcc gacgtggtcg tgatagaatg 749401 ccttgatgtt gctggcgcct tttcctgaga attcactgtc actgagatca gcgactcctt 749461 ttaacgcttt tctcaagttg accatttgcg ttcttagttc tttgtactct tttgcacggt 749521 ctgtcgcttc cgaaagcagt gttttcgctt caaatacttt catgaccatt tcccttcttt 749581 tgttcgctca atatcaaaat tttaccacgg gtcgggataa ggtgggggtg agaacgtgtt 749641 ttggtggaaa aatgagtcat ttggcatgtg tctttattcg tggagggatt ggaggaaaca 749701 tggtcgaaat gatattgatt gctacacatt ttttggaagt ttgtattcta tattgttttt 749761 taaggagcat gttgatgacg aaaaaacgga ttacatttgg tttattagtt ttaatggtat 749821 gtgtcatcct gtttgttctg tatgttcagt tacgcaataa agatagtatt cctgtccaat 749881 cttccgccat tcaccccgaa gaagaccgca tcttttttat ttactccaat cctttcataa 749941 aagaaagcgt gctgctttca acctctacag gcgaacggtt taacaggcgt acgtttaagg 750001 tggcggatgt gccttatatt caaacgaaat cttatgcatc aacagacctt gtattattgg 750061 cggaacacga gcctttttac tacacgctgg agaaggatgt gatcaaagag catccgctgt 750121 cagatccatt tgcgttttgg tatgagggga aggatgtcac tattgaggcc tataatgttg 750181 atacgacggg aaatgagatc cacataaacg acagaaaaac gaaaaaggaa tataccctta 750241 ccttgcctcc gcttgtcaca atgggggcca gtgatgagaa ctttatttat atcattcaaa 750301 gcatgtctat ttacgtgatt gacagaaaaa cagaggaaat gattgagacc ctgagcttag 750361 cctcatacgc tgatcaattc gcagactcgg aggaatttat cgtcgcgagc tcggatcata 750421 aattgactgt gattgaaaaa gggacatgga agacgacata tattgcgtat cctgaagatc 750481 ttgaatatgc agatactgtg tactatgaca aagaaagcgg cagtttttac gtggcgtacg 750541 aggacaaaga gggtggagcg aacttgctgg aatatgggga ggatttttct attcacacat 750601 acagcttgaa attcccttat atggaggcga agtttaaggg gaatctattg tatatagttg 750661 cccaggaaga gcataaaaag ggcatcggcg gatacgtggg tgtgtttgat atccattcta 750721 aggagatgct ttatcagttt gatttgcctg aggaacaggt gaaggttcag gattttgttg 750781 tggttgacaa taagtgaata ctatatgaaa tagaatgaca aagacccttg cataaagggt 750841 tcttttttat gaaaaaaaca aattgacagg atgaaaaaac aatttcttcc ttctatattg 750901 ttttcaaaat ttgggattga tagaatatga catatctcat agagaaggag ggaagccgtt 750961 gagtcaagcc ataccgtctt cgcgtgttgg tgttaagatt aatgaatggt ataaaatgat 751021 tcgccagttc agtgttccgg atgctgagat tctgaaagcg gaggttgagc aggacattca 751081 gcagatggaa gaagatcagg atttactgat ctattattct ctgatgtgtt ttcggcacca 751141 gctgatgctt gattatttgg agccgggaaa aacatacggg aatcgcccta cagtgacaga 751201 gcttcttgaa acgatcgaga cccctcagaa aaaactcaca ggtcttttga aatactactc 751261 tttgtttttc cgcggcatgt atgaatttga ccaaaaagaa tatgtggaag cgatcggata 751321 ttatcgcgag gcggagaaag aactgccgtt tgtgtcagat gatattgaga aagcggaatt 751381 ccattttaaa gtggcagaag cgtattatca catgaagcaa acccatgtgt cgatgtatca 751441 tattcttcaa gccttggaca tttatcaaaa ccatcctcta tacagcatta gaacgataca 751501 aagcttgttt gtgatcgccg gcaactatga tgatttcaaa cattatgata aagcgctccc 751561 gcatttagag gcggcgctgg aattggcaat ggacattcaa aatgacaggt ttatcgccat 751621 ttctctattg aacattgcaa acagctatga cagatcagga gacgatcaga tggctgtaga 751681 acatttccaa aaagcggcga aagtaagcag agagaaagtg cctgatctgc ttccgaaagt 751741 cttgtttgga ttaagctgga cattatgtaa agcgggccaa acacagaagg cgtttcagtt 751801 catagaggaa ggattagacc atatcacagc acgttctcac aaattttata aagaattgtt 751861 tctgttcttg caggccgtgt acaaggagac tgttgatgaa cgaaaaattc atgatctttt 751921 aagctatttc gaaaaaaaga acctgcacgc ttacattgaa gcatgtgccc ggagtgctgc 751981 cgctgttttt gaaagcagct gtcactttga acaagcagct gcgttttatc ggaaagtgct 752041 gaaagcccaa gaagatattc taaaaggaga gtgtttatat gcctattaag aaaaaagtga 752101 tgatgtgtct ggctgttact ctagttttcg gaagcatgtc gtttccaacc ctgacaaact 752161 ccggtggatt taaggaatcg acagatcgaa atacgacgta tatcgatcat tccccttaca 752221 aacttagtga tcagaagaaa gcccttagct agggcttttt cttgctttac ggaagacgtt 752281 ccattttcca catcgcggca ttccttctat ttctaacgca agacactcga aacaaccaaa 752341 ccatttgagg tataatggat aaagtgaata acagtattta gattgatata tatgaaagag 752401 agtggaacat catgggccgt aagtggaaca atattaaaga gaagaaggcg tctaaggacg 752461 caaatacgag tcggatttat gcgaagtttg gccgtgagat ttatgtggcg gcgaaacagg 752521 gcgagcctga tccggaatcc aaccaggcgc tgaaggttgt gcttgaacgt gcgaagactt 752581 acagcgtgcc gaaaaacatc attgaacgtg cgatcgagaa ggcgaagggc ggagcggaag 752641 agaattacga tgagcttcgt tatgagggct tcgggccgaa cggatcaatg attatcgttg 752701 atgcgctgac gaataatgta aaccgtacgg cgccggaagt gcgtgcggcg ttcgggaaaa 752761 acggcggaaa catgggtgtg agcggatctg ttgcttacat gtttgacgcg acggctgtaa 752821 tcggtgtgga aggcaaaacg gctgacgaag cgcttgaaat cctgatggaa gcggatgttg 752881 atgtacgtga cattttagaa gaggatgaca gcgcgatcgt gtatgccgag cctgatcaat 752941 tccatgcggt gcaagaggcg tttaaaaacg cgggtgtcga ggaatttaca gtagcggagc 753001 tgacaatgct tgcgcaaagt gaagtaacgc ttccggatga tgcaaaggaa cagtttgaaa 753061 aattgattga tgcattagaa gatttggaag atgttcagca ggtatatcat aacgttgatt 753121 taggtgagta aggagtgagc aggctgttat ggcctgcttt ttttgtcccg gaaattgttt 753181 tagctgtatg taggcggccg cctatacgat ctataagata ttctcatact ctggactgta 753241 acctatgtga aggagagagt aaatatgact gatacaagac atatgtatgg cggacctggt 753301 tttggtcatt atcagggctt tggtattggc cacccgggct atggcatgca aagcacaggc 753361 tatccgggct atggcatgta tggaggccac ccgggctatg gcatgcaagg ctacccagat 753421 cacggcatac atggaggagt cggcggctat ccgggatatg gtgggtacgg cggttaccca 753481 agcggcggct atggaggctc tccgggaact ggaagctatc cgagcatgca ccatgaaaat 753541 gatggccatc accactatta tcaccatcat catgatggaa aagataatct tcatcaccat 753601 catcaccatg ttggaaagga taatcatcac caccatcatg atggtcatta tggccaccat 753661 catcaccata tgggccactg gggaaaagac ggttataaat aaagaagatg atgataaaaa 753721 gaggacactc ttgcagatca agagtgtttt tttagctttt ttcttgactg ttcagtctgg 753781 aaaatggtaa catttgtttc aggaggtgat cattttttgg ggaggaataa agaatttgat 753841 acggcgcttg ttcttcacag ggcgatagag gtttttggag agtatggcta cgaaggaacg 753901 tctcttcagg atctgctctc tcatttaggc attgcgcgcc aaagtttgta tgatacgtat 753961 ggaacgaagc gtgatttgtt tttgtccgct gtgaaatcgt atcttgaagg gaaaaacgct 754021 gccgttatgg aaaggcttga agcgccagga tctgtaaagg aagccattcg tgatattttt 754081 caggagggtg tcaatgccct gagggatccg gaacgggcga aggcgtgcta cattattaac 754141 agcgcgattg aacagatccc gcatgaccct gagcttgccc ggtattttga aagacaatcc 754201 aagcagcttg aggacgcttt ttatcacggg cttttaagag cgaaggatca aggagaattg 754261 aatggcgaag atactgatat atctgcgctt gctcggtacc tgaatcagag caggctgtca 754321 ctgacattta ttgcaaaagt gacggcagat atggatcggc ttcaggacca tgttgacgtg 754381 agtttatcag tgcttgatta acatgtggta aaggattctt tgcccatgta tgtacttttt 754441 ggactgaata gtctagaaat aaaaatgagg tgatgatgaa tgttgatgaa tgagtttgaa 754501 aaagcatgtg aaacattgag aaagtttatg gcttatatgc ttgagaagga catgaagagc 754561 tggacggagc tttgggatga gaatgctgta tttgagtttc cttatgcgcc ggagggatca 754621 ccaaaaagaa tagaaggaaa agcggccatt tacgattata ttaaagatta tcctaagcag 754681 attcatcttt cttcatttac cgctccgaca gtgtaccgtt cagcagactc gaatacggtg 754741 attgcggagt ttcaatgtga cggccatgtg attgagactg gactgcctta tcgccaaagc 754801 tatatcagtg tcatcgaaac gagagacggc cgcattgtgc gttataggga ttattggaat 754861 ccgcttgttg taaaagaggc ctttggagga tcatttttgc aaacagagga gagtgggaaa 754921 tgatgaaaca gaatccgatt ttaatcacgg gcgggaccgg cacagtcggc agccgaatcg 754981 ccagccgttt aataaagctg ggatacagag tgcgtattgc aagccggaaa aagggcgcgc 755041 ttgctgatgc tgagtatgtg tattttaatt ggaagtacgc ctccagtttt acgcctgctc 755101 tggaacaggt aaaacagatc tatcttgttg ctccggtcgg tgtatttgat ccggctccct 755161 atgtgcttcc ctttttaaag gaagcaaagc gtctcggcgc aaagcgggta gtgatgcaaa 755221 gtgcgtctgt tgtctccgag aacggtcccg tgtttggcgc gcttcaccag gcagtgcgcg 755281 agtttccaga atggacggtg ctgcggccct catactttat gcaaaatttc atcaatgtcc 755341 agcaccgcat gtctattcaa acggaggggc gcatcacaac ggcttcgggt gaaggaaaac 755401 ttgggtttat tgacgctgat gacatcgcag aaacagccgt cagggctttg attgatgatg 755461 ttcctcatca aacacatcat attctgacag gtcccgaggc gctgagctat gccgaagcgg 755521 cggagatcat tggagctgcg gcgggacgcc gggtggagca tgtcagcatt tctcgttccg 755581 agctgcagca taaaatggag gcaggaggtt tgcccgcgga ttatgcccat tttatggcga 755641 agcttgatga ggcaattagc catggtgcgg aacatcgggt aacggataca gtgaagcgtg 755701 tgacgggaaa agaacctcgt tcgctgtcag agtttgcggc tgctcatgct gcatattgga 755761 cctcattttg gactgaatag tctagaaaga ccttcggcgc ttccgaaggt cttcttattg 755821 aaaaagctaa gtcgtgtttt agtcataatc atgcctcctg cctcatacct attaaggtca 755881 ttgtttttga gaaaggagga gccggaatga aggatatgca gccgtttacg cctgtcaaat 755941 catatacgcc ctttcacagc cgttttgatc cctgtccgcc catagggaag aaatattaca 756001 gaacgccccc taacctttat atgacctttc agcctgagca catggagcag ttttcgccga 756061 tggaggcttt gaggaaaggc accctttgga aggatctcta tgatttttat gaaaaccctt 756121 atcgaggggg agacgcacat ggcaaaaaag gttgacgccg aatattatcg tcagctagag 756181 caaatacagg ctgctgattt tgtgcttgtt gagctgagtc tttatttaaa tacacatcct 756241 catgatgaag atgcgttgaa gcaattcaat caatattccg gctattcaag gcacttaaaa 756301 agacagttcg aatcctctta cggaccgctt ctgcagttcg gcaacagccc cgcgggcaag 756361 gattgggatt ggggaaaagg gccatggccg tggcaagtat aaggaggaat gcctgaatgt 756421 gggtgtatga aaagaagctg caataccctg tcaaggtcag tacgtgcaac ccgacgctgg 756481 cgaagtattt gattgagcag tatggcggag cggacggcga gctggccgcg gctctccggt 756541 atttgaacca gcgttatacg attcctgata aggtcatcgg ccttttaaca gatatcggca 756601 cggaggagtt tgcccatttg gaaatgattg cgaccatggt ctataagtta acgaaagacg 756661 ccacaccgga gcagctgcgt gaagctgggc ttggcgatca ttacgtcaat cacgacagcg 756721 cgctttttta tcataatgcg gcgggcgtgc cgtttaccgc gagctatatc caagcgaagg 756781 gcgatccgat tgccgattta tacgaagata ttgccgcaga agaaaaggcg cgggcgacgt 756841 atcaatggct gattgatatt tcggatgatc ctgatttaaa cgattccctg cgttttttgc 756901 gtgagcgtga aatcgtacac tctatgcgct tcagagaagc ggttgaaatt ttaaaagaag 756961 aacgggataa aaagaagatt ttctaatagg cagattggcc tctctttcat acaccctttt 757021 acatacagag aaaatggtct gtttttgcag tttggtctgc attataatca aggtgtgtgt 757081 gcaagcttac tttttgattg ggaggccttt atgacagctt ttaagattga gaacgaaacg 757141 attgcagatg gattttacgc gtgtccggcc gtctatgagg atgcagaatc gattaccggg 757201 ttgctcgtcc gaacagctga atggctccgg gatcggggtt ctaaccaatg gagcggactt 757261 ctcaaagggc aagatataca tgatatcacg gggtcaattg aaaagggaca tgtgtttgtg 757321 tttaaaaaag atgaagagct tgcggctgtc gtgatgctgc tgcctgcacc gagcgagtgg 757381 gaccggacgc tttggggaga cgatgggcat gaggagtcca tttatttaca ccgcctcgca 757441 gtaagccgcc ggtttgcggg acaggggctt ggagcccgcg tccttcagtg ggcggagacg 757501 ggcatacact ttccggaaaa aacgcggatc cggcttgact gtgtcgctga tagtgacgcc 757561 ctgcattcct tttatcggcg tatgggatat gaattcatgg gtgctgatgc gtccggatat 757621 catttgtttg agaaagagat tacggcagaa taagcgtcct ttgcaggggg cttttttgtc 757681 tttttctaaa agggaggcag gcgatgtgtg gtcaatatta tttgtgacag ggattgtgac 757741 ggcttgtctg tttgctggcg tatccgtatt gatgcggatg agatttcctg acaaaagtcg 757801 gccggaatgg atgttggccg ggctgatcgt ccttggtgtg tttgcgatct ggtacagcct 757861 cgtgtatgta cgcggctggg aaggggctgc gctcggaatg cttggattca atgtcatttt 757921 cggagccatt gccggatatt tgatcgataa ggccatccgg cgttacagga aaagataagg 757981 ctgctgccgt ctctcaacag gtcgaaattt tcacagaccg gcaggaattt tctttcgaaa 758041 ggagaaatac atattacttt aaaatgaaag cgttttccaa agcaggaagg tgatgttgat 758101 gatacacagt gtggcaaatg ggctgaatca tttttgtacg tgggtgatga gactggccta 758161 tttgaatgtg ctttggattt tgttttctct tgcaggcctg gttgtatttg ggctgatgcc 758221 cgctactgcc gcgatgttta cagtggcgag agaatgggcg aaggggaata cagatgcccc 758281 ggtgttttct gtcttttttc ggacgtttaa aaaggaatgg cgggcatcac agatcctcgg 758341 gcttatcgtt gtgacggctg ccctgtttct gtttgcggat atgcggatag cggctcagat 758401 ggaccagcct gtgctcgtca atgtattcgt gagcattagt ttgattttcg cgtttgttgt 758461 gctgtatgtg ttcccggtat tttctcattt tgacgtaaaa atcagagagg tgctgagcat 758521 cagctttttc attgccttca gtcgtccggc ggtgacgctt ttgatggcag cgggcgctgt 758581 cggtgtgctt tgtctcgttc tgtttcatgt cacgtttcta ttgtttttca gcgggagttt 758641 actcagcctg atcttaacga agctgtcctt taaagcgttt cggtcaatgg atcagcggca 758701 ggagaaagaa aaggcggcat gaagaaaaga gttgctggct ggtacaggcg gatgaagatt 758761 aaggataagc tgtttgtgtt tctatcgttg attatggccg tatcctttct gtttgtatac 758821 agcggggtcc agtatgcctt tcatgtgtat gatgagcaga tttaccgcaa gtcctcggag 758881 gtgcttcgga tgtcttctga aaggatcgaa gacgagctga agaagataga ggatgtgtca 758941 tatgaaatca ttacagacga acagattcag cgcatcctga gcatgcaaaa tcgggatgat 759001 acgtatgatc aatatcaaat gaagcaggag ctgtgggatc agcttgcggg atatgccagc 759061 gatgaaaagt acatcgattc cattcatgtg attgatgccc gcggctcaga gtattcagcc 759121 ggaagcagtt cttcagatct tttgcagcag gagcaggaag aggtatttaa gcgagcgaaa 759181 gcgaaaagtg gaagaaatct ttggatgacg ctcggcgggt cagaccccgt cctgatttca 759241 gcacggcaga tcaggtccta tcaccagctg agtctgaacg gcttgggcat ggtactgatc 759301 caggtcaatg taaaacagat gattcgtgat gtgccgaagg attggggcga ttcagtcgga 759361 gacattatga ttgctgacca aggcggtaat ttggtgtata cggcacatgc atcagcgcat 759421 gttcctgagg cagcaaaaga gacgttgaag caccccggtt atgacttgat aaaaaagaat 759481 ggcaaacgtt actttatttc ttatcttcaa tcatcctacc aaaattggag ctactataac 759541 gttatcccct ttgatcagat gttcgcaaaa atttccttta tgaaaacagt gatcggcaca 759601 tgctttcttc tctttttctg tgtggttttg cttttcggaa ggaaaatcgc caacagcatc 759661 acggagccga ttgaacagct tgtgaccgcg atgaaatcgg tacagcacag cggcattgaa 759721 gcaggtgtgt cgctttctct gccggaacat acacaggatg aggccggcat gctgaaccgc 759781 cattttactg tcatgatgaa acggattaat gagctgatgg aagaaaatgt ggaaaaacag 759841 ctcatcatta aagaaaccga attgaaagca ctgcaagccc agatcaatcc gcatttttta 759901 tataacacgc tcgagtccat caattggctg gccaaggcga atcagcaaaa gcaaatctca 759961 aaaatggtgg aatcgctcgg ttttcttctg cgaaacagca tacatatgaa gaaggatatc 760021 gtgaccattc aggaggaggc ggacattgta cgtcactata tgaccattca gcgatttcga 760081 tttgaagagc gcctgaaatt cacgttggat attgacgatg aggtgaagca ttgcctcatt 760141 ccgaaactga cgctccagcc gcttgcggaa aatgcgattc aatacgcgct tgaacccttt 760201 acaaggccat gcgccatccg gattcaggcg aaaaaggcga agggctgtgt ctgtattacg 760261 gtcgaagata acggccctgg catggatgga cggattcttg aatcaacggg tggaagagga 760321 atcggacttt ggaatattcg cgagcgcatc agcctgacat tcggagagcc atacggattg 760381 cggattcata gtgagcatga aaaggggacg aggattgtga tcacaatacc gtgccgaaat 760441 gaggtggtgt gatgtataaa atactgctgg ctgatgatga gaggattatc cttgatggaa 760501 tggcgggaat cattgagtgg gagtcgcttg gcgcctcatt gatcggaaaa gcgcagaacg 760561 gacatgaagc atatgaaaag attgtacata agcagccgca tatcgtcatc acagacgtca 760621 aaatgcccgg catggacggg cttgagctga tcaaaaaggt gtcagccgtc agcccgtcgg 760681 tgcaatttat cgtcctgtcc gggtttggag agtttgagta cgcaaaggaa gccatgaaat 760741 atggggtgaa gcattatttg ctgaaaccct gcaatgaaca gcagattatc agctcgctgg 760801 aggaaatcat tgctgagctg aagcggcaag atgtgcacaa aaagaaaaca gcccatctga 760861 aacacgagct ggaccatatc cgttcctttg cagccgatca atacttggaa ggcttgatcg 760921 ccggtgtggc ccagctttct ccgccgcctt cacttgccgg aaaaaagatc cgcctcttga 760981 tcttaaaagg ggaacaatct attgatgctg cagccagaga ggcactcgga tcggcactga 761041 cagcggtttg cagcagcggt gaatggaccg tgctcgccgt agaggagaac gccgctgaaa 761101 aggtggcgga ggtttttgcg gaccgcaaga tggccatcag tcaggcggga gaactccggc 761161 acgcggggca gctgtttcgt gacacagctg aagcgtctgg tgacctgcat gggagcgcag 761221 tgatttcaaa aatgatcagg cttattgccg acgagctcgg aaatccgaat ctgtccttaa 761281 aatgggcggc gaaggatatg ctgtttatga atcctgatta tctcgggaag ttatttaagc 761341 aggaaacagg cgagaaattt tcccaatatg ttacacgggt gcgtcttgag catgcgatga 761401 agcagatgaa aataaggagg gacgtgagcg tttcagaaat tgctgaagaa atcgggtttg 761461 gcgataatcc gaagtatttc agtcttgttt ttaaaaaata taccggtctg acaccgtcag 761521 aattcagaag aaaacaggga ggcgcttccg caggatagcc atctctgttt ttttgacttt 761581 cgccactgtt ttttgagtgt ttcgccctat ccgaacgctt taaaataaaa tgtaagcact 761641 tacattaaag gggggattgg tttgaagaag atttgttacg tgctgttatc ccttgtctgc 761701 gtctttttgt tcagcggatg ttcagcgggt gaagaggcct cgggaaaaaa agaagatgtt 761761 acactcagaa tcgcgtggtg gggcgggcag ccaaggcatg attatacaac taaggtaatt 761821 gaactatacg agaaaaagaa tccgcacgtc catattgaag cggaatttgc gaactgggat 761881 gactactgga aaaagcttgc gcccatgtct gccgccggcc agcttcctga tgtcattcaa 761941 atggataccg cttacttagc ccaatacgga aagaagaacc agctggaaga tttaacgccg 762001 tatacaaagg atggaacgat tgacgtcagt tcaatcgacg agaatatgct gtcgggcgga 762061 aaaatcgaca ataagcttta tggatttacg ctaggtgtca acgtgctgtc tgtgattgcc 762121 aatgaagatt tgctgaaaaa agccggtgtg tctatcaatc aggaaaactg gacgtgggag 762181 gattacgaga agctggcgta tgatcttcag gaaaaagccg gtgtctacgg ttccaacgga 762241 atgcatccgc ctgatatttt cttcccttat tatttgcgca caaagggtga gcgcttttat 762301 aaagaagacg gcactggcct cgcgtatcaa gatgatcagc tgtttgtcga ttactttgaa 762361 cggcagctga ggctagtgaa agcgaaaacg tccccaacac ctgatgaaag cgcacagatt 762421 aaagggatgg aagacgattt tatcgtcaaa ggcaaatcag cgattacatg gaactactcc 762481 aatcaatatt tgggctttgc ccggctgaca gactcgccgc tgtctctcta tctgccgccg 762541 gagcaaatgc aggaaaaggc gctgacactg aagcccagta tgctgttttc cattccgaaa 762601 agctctgagc ataaaaaaga ggcagcgaaa tttattaatt tcttcgtgaa taatgaggaa 762661 gcgaaccagc tgattaaagg cgagcgaggc gttccagtct ccgacaaggt ggcggatgcg 762721 attaaaccga agctgaatga ggaagaaacc aacatcgtgg agtatgtaga aaccgcgtca 762781 aaaaacatca gcaaagccga tccgccagag cctgtgggaa gcgcggaggt catcaagctg 762841 ctgaaagata cgtcagatca gattctgtat cagaaggtat cgccggaaaa agccgccaaa 762901 acgttccgga aaaaggccaa tgagatatta gagaggaata attgacggga aatggggctg 762961 acgcaatgaa aaaaagccgg agtataagaa aagacaatct ggcgggatat gcttttattt 763021 ctccgtttat catcgggttc ctatgcttta cggtgattcc gatgggggcg tccctgtttc 763081 tgtccttcac gagctatgac ttgtttacgg cgccgaaatg gatcgggctc gacaacttta 763141 aggaaatgtt tacgggtgac gaaaagtatt ggcagtctct gaaggtgacg tttacgtatg 763201 tgcttgccgg ggttccgctc cgcctcggct tcgcgctttt tatcgctgtc attttaaaca 763261 atgcagcaaa aggaacggcc atttacagaa cgctctttta tctgccttcg atcatcggcg 763321 ggagcgtcgc cgtggcgatt atgtggcgca atatttttgg caatgacggg gtcatcaatg 763381 cgctgctgtt ttttgtcggg attgatcaaa aaattctttg gtaccagaat ccgacaagtg 763441 cgctgtggac attgattctg ctgtccgtct ggcagttcgg gtcgtcaatg ctgatttttt 763501 tggccgggct gaaaaacatt ccgtcttcgt atttggaagc ggcaagtgtg gatggggcaa 763561 atcgggtgca gcgtttcttc aagatcacgc ttccgatcct tacaccgatt attttcttta 763621 acctagtgat gcagacgatt tctgctttta tgacatttac acctgcctat atcatttcga 763681 agggcgaggg cgggccgctt gacgggacac ttctctattc gctctatttg ttccagcgtg 763741 cgtttaacta ttttcaaatg ggctacgcat cggcgatggc gtgggtcatg cttgtcattg 763801 tcgggctgat tacgctcata ttgtttaaaa catcgtcata ttgggttcat tacgagtcaa 763861 aggaggaatg acggatggag ccggtcaacc agcctgtcag agaagccccg gtttttgaga 763921 gaaaaaaagc cgggcgcgtc agtcccaaac gcatactgtt ccatgttttt acggcaacgc 763981 tggcggtgtt gctgctgtac ccggttattt ggctgtttgt cagctcgttt aaagaaagcg 764041 ccagtatttt tacaacctca cattctctca ttccagaccc ttttattctc agtaactatg 764101 ctgaagggtg gaagggcatt gcgggacagc cgtttctgac gtttattaaa aactcggcga 764161 ttattgtcgg gctgtcaaca atcggtgccg tcatgtcatc ggctgtcatt gcgtacggat 764221 ttgcgcgtat accgtttaag ggaaaaaaat tttggtttgc gtgcatgatg gggacgttaa 764281 tgctgcctca tgaagtgttg atgattccgc agtatattat gtttgcgaaa ttagactggc 764341 tgaattcctt taaaccaatt gtcgttccgc aatttttcgg gcatgcgttt tttatctttc 764401 tgatgatcca gtttatccgg acgattcccg aggagctgga tgaagccgcg cgaatcgacg 764461 gatgcggacg ctttgcctgc ttttggcgga tcattctccc gctgattgcc cccgcgcttg 764521 cgacgtctgc gattttctcc ttctattgga agtgggagga gctgattcag ccgctcttgt 764581 atttgaataa gccggagctt taccctgttt cacttgcgct gaagcttttt ctcgatacag 764641 agtcggcttc gaactggggc gcgatgtttg ccatgtcagc cgtctcgtta ttgcctgtga 764701 ttcttgtttt ctttttgttt cagaaatata tcgttcaggg catcagtacg accggattaa 764761 aataaaaagg agtgttgcag atggcacagc ttatctttga tgaagaaaag gtgacgtcgg 764821 ttattgaccg gatcgtgaaa cggacatttc agatggattt tgcgtgggat tggccgggcg 764881 gcgttgcgtt ttacggtgtg gcggaggcct atgaagcgac ggaaaacgag gaatatatca 764941 atctgttaaa aacgtgggtg gatgaacagc tggaggatgg gctgccgccg ctttcgatca 765001 acggagtttc cattgggcat acgcttttgt tcctccacaa ggtgacaggt gatgacgtgt 765061 atttggaaac agcggccgag atggcggaat atgtgctgca taaggcgccg cgctttggcg 765121 agggtatcct tcagcatacg gtgaatgcgg cagaatacgt attccctgaa caggcatggg 765181 cggatacgct gatgatggct gggctgttta tgctgagaat cgggcgggtc atggagcgtg 765241 aggattattt tgaagacggc ctgcgccagt ttcacggaca tgaggatgtg cttcaggacc 765301 ctgtcacgaa tttgtactac cacgcctggg acaacaaagc gcaaaatcat ctgtcgggga 765361 tttattgggg cagggcgaac ggctgggcgg cactcacgat ggcaaaggcg ctcccgctta 765421 ttgaggtgac acatccttcc tttatgatca tcgacggatc gctcagagac cagctgagcg 765481 cgcttgtccg gcttcaggat gaatcagggc tgtggcatac aattttggat gatccggatt 765541 cttatctgga ggtttcggca tcagcgggta ttgcttctgc tctgatgtcg agcggaaagc 765601 tgtatacaaa atatgtgcag aaatcgcttg ccgccatttt ggatgcagtg gaagaggacg 765661 gacgggtcag cagggtatcg gccgggacag ccgtcatgaa aaatgccgaa ggatacaaac 765721 aggtgcctta caaacgaata caaggatggg ggcagggact tgcgctgacg tttcttgctg 765781 atgttttgaa aacgaaaaaa cgcttgtatc agtaaagata gcggcggggg gagagggatg 765841 aaaaaacagc ctcaacagaa ggaacgggtt tctcgctgga agggaacgta tttcaaaaga 765901 aactttgtct tcattttgct gattgcctgt attcccggat tgctgactgg cggcgcaatc 765961 tactttcttt cgatcgacaa ggtggagaaa gagctgcaga gatcgcatga aacacaggtg 766021 gcgcgtgagg tcagccgaat ggatgagaag ctgggagtgc ttgaactggc actcacccag 766081 atggcctacg attcttcact gatgaacgga ttggccgaga gggatttgga gaaagacttt 766141 acgttctcct atcaattaac gaaaaagctg tttcttttgc gggatcagca gccgctgatc 766201 gagcaggctt ccatctttct gaacagcccc cggccacttg tgctgagccc tgaatacagc 766261 gctttgacag aacaggaggc gcttcgcaag tatcgctcgc tgcttgcctc agaccacagc 766321 atttattgga aacggtcggg aaaccaagcg atgctgatcc agctcattcc gggcgcggcg 766381 gagaaaccgt tcggcgcgat catgctggcg gttgatccga aagaaatgga atcaatcctg 766441 caaagcttgt ccccctatcc tgatggcagt gcgttgcttt tagatcaaaa tcgagaggtg 766501 ctgtttcatg agggggaaaa agattttgaa aagactttac ttcatgagat aaaaaaacag 766561 cctgctgaga acggccattt tcagatggaa tggaaaggca aggtgtattc tgtctccttt 766621 ggagaaatga accggatgca tcagcaatgg acctttgtgt cagcggcgcc tctttcagct 766681 attacagcgc cgatggtgtt tttatcaaaa gtgatcatcg tgatgctggt catttgcatc 766741 ggtttggcgg tgtgcatgac atggtatgca tcaaaaaaaa tctatcgtcc catccagcat 766801 ttgcttggct tgtttaccgg aggagagaag aaaacatggc aggcgtccgg gcaggatgaa 766861 ttcaaatgga ttgaaaagag atggcaggat ctatcccttg aaagccggaa gctccaacag 766921 cagctcctgc ggcagacgcc ccatatgaaa aagagttttt tgcagcatct cttacagagc 766981 gatttttact atgacaacga ggaaagcctc agatttcgga tggaggaggc tggctggaac 767041 atcggcggaa acgtgtttca tgtgcttgat ctacaggtga cagggctccg ctgtgaaaaa 767101 agcatcttcc gtgaaggtga tgaacagctt gccgtgttta cactgactaa tatcgctgag 767161 gaattggcgg ctaaacgcgt ttttcagctc tccatacttg atatcggccg gctttctgtc 767221 accgttcttg tgatgaaaac aaacagctct gatctgaagg cgtatataac ggagctggca 767281 cgccaatttg gagatgtaac cggactatgc ctgacctcga cattgagcag caagacggag 767341 cgtgtcacgg aaattccttc tttatttcag gatgtgaaat gcggcaaatc ccgcaggaag 767401 tttgctaacc gggatcaggt cattgatttg caggccgact tccctcggga tgagcagttc 767461 gctccttatt acccttttga gctggaaaaa caaattgttc agaccatccg gctggaaaga 767521 aaacaggaag ccaaggaact gatagatgga tgtatgaagg aactgtcgga aaaagcggcc 767581 atagacaggc atgtgcattc cgccctgatt cagctgtttt cccgcattca ggaggatatt 767641 ttgcattccg ggctcaatcc cagcgaactg tttcagcacc ggaatccgtt tcttgatatt 767701 tcagaattgc gcgaacctaa cgaagcggcg gcctggctga tggatgtagt ggtgacgcct 767761 tacctttcca agcttgaggg cagaaaaaac agacagcaaa agcagctggc agaacgtgtg 767821 attgcgatga ttcacgaaca gtatatggcg gacatttcat tggaaagctg tgccgatgcg 767881 cttggcatga attcctatac gttaagcaag gcatttaagc aagtgaccgg cattaatttt 767941 atcgattatg tgacccagat cagaatcgaa aaggcgaaag aactgctggt caatacgaat 768001 aaaaaaattc atgatgtgtc tgaagaagtc ggctatcgcc acaattattt caatcggatt 768061 tttaaaaaac aggtcggcat gccgccgggt gtcttcaggc aaatgtatca ggaaacgccg 768121 tgaaaggaga gaacatgtga tgaagaaacc gattcaagta tttttagcgg gggattccac 768181 tgtgagtgac tgcccgcctc atgaagcgcc gatggcgggg tgggggcagg tattcgggca 768241 attgttttct gaaggtgtgc tggtccgcaa tcatgccaaa ggaggagcga gcaccaattc 768301 ttttgtggag gaaggaaggc ttcaagcaat tgccgagcac atcacacaag gcgattattt 768361 gttgattcaa ttcggccaca atgaccaaaa accgcggggg acgaagccgt actccacatt 768421 tcagcagttt cttaccttgt ttgcagatac ggcacgcgaa aagggcgcgc atcctgtgtt 768481 cgtcacatcg gtgcagcgcc gccgctttga tgaaaacgga cggatcgagc atacgctcgg 768541 tgagtatccc gatgcgatga aagcactggc gaaggagctc gatgtacctg tgattgatct 768601 gcttgcgaaa acaaaggtgc tgtatgaagc atacgggccg gaggagtcga agcgattgtt 768661 cgtttggttt cagccgaatg aacatccgaa ttacccggac ggcattgagg acaatacgca 768721 tttttcggaa aaaggtgcaa tggaggttgc gaagcttgtg gcagaaggca ttgaagagct 768781 cggacttccg cttaaggacc accttgtgag ccgggaggga aaagaacatg tataaggaag 768841 gcgcttgctt gtaccgcaat ccgctccggt ctaaaagcga tgtgaaggat tggcggatgg 768901 agggaggcgg acagatctca tttgacgatc acagcttgca cctgtcacat gtccaggatg 768961 aagcgcactt tgtcttttgg tgtccggaaa cctttccaga cggcatcatt gtgacatggg 769021 acttctctcc gatcgagcag cctggactgt gtatgctgtt ttttgccgct gcgggtattc 769081 gcggcgagga tttgtttgac ccaagtctca ggaaaagaac aggaacatac cctgagtatc 769141 attcaggaga tatcaatgcc ctccacctgt cgtatttccg cagaaaatac gcggaggaaa 769201 gagcgttccg cacctgcaat ttaagaaaaa gccgcggttt ccatctcgcc gcaatggggg 769261 ccgatccgct gccttctcca gacgacgctg attctccgta tcgtatgaag ctgatcaaag 769321 acaaaggcta tgtgcacttt tcaatcaatg gtctgcccat tcttgagtgg atggacgacg 769381 gcagcacata tgggcctgtg ttaacaaaag gaaaaatcgg gttccggcag atggccccca 769441 tgaaagccgt ttacagggat tttgccgtgc atcaagcggt gagaagatga agacgactgt 769501 aacggatgcg ctttatgcag gctgcgaagc ggtggtgaaa atagcatggc tcaacgggct 769561 gtggctgttg tttacacttt tgggcggcgt tcttttcgga tgggcgccga gcacagctgc 769621 gatgtgtgcc gttataagga aatggctgat ggggcaaaag gatgtcccga tattttcgtt 769681 atttctcgat acctataaaa aagagtttct caaggttaat gcgatcggat tggcgttttc 769741 ggctcttttg ctcatattgt ctgccaacta tcattatttt tctgccagta cgaattggct 769801 gtcctttgcc gtaacaagct gcacgctgct tgcagggctt ttgtatatca tcgcgctgat 769861 gtatgtgttt cccctttatg tgcattacca gctcccgctt cgcaaatata ttccgcaggc 769921 actgctgttt ggcgccatga gaccgctgac aactggctgt atgctgatcg ggtgcggatt 769981 tgtcctttat ttgctgtata cgcttcctgg cctgatccca ttttacggcc cgtgtttatt 770041 tgggcttgtg ttgatgtttt ttgctcttag gggatttcaa aagacggagg cccagcacca 770101 tcaagccggg taacaaaaaa atgacaaata agcaaaaaag tgcagtgtcc gaaataggca 770161 gatgcaaaaa agtgaaattg aagacagctc acaaagcgca taaaatccaa tttaagtaag 770221 cgcttacaga taaatgagaa ggagctgtct gatgattaga cgaaggaaac gcatgtttac 770281 cgctgttacg ttgctggtct tgttggtgat gggaacctct gtatgtcctg tgaaagctga 770341 aggggcagcg cggcagatgg aagcgctgaa ccgggggctt gtagcggtca agacggacgg 770401 gggcattttt gtcagctggc ggtttcttgg aaccgaaaac gcatctgttt tgttcaatgt 770461 gtacagagac gggcaaaaac tgaatgctgc gcctgtcaaa acaacgaact atgtggataa 770521 aaacggttcg gcgggctcaa cgtatacggt tcgggctgtt gtaaacggta ccgaacagcc 770581 ggcttctgaa aaagcctccg tatgggcgca gccgtatcat tccgtcccgc tggataaacc 770641 ggctggcggc acgacgccaa agggtgaatc ttacacgtac agcgctaatg acgcaagtgt 770701 tggcgatgtg gatggtgacg ggcaatacga gctgatcctg aaatgggacc cgtccaactc 770761 aaaagacaat tcacaggatg gctatacggg tgacgtgctg attgacgcgt ataaactgga 770821 cggcacaaag ttatggcgga tcaatctcgg caaaaacatc agagcgggcg cgcactacac 770881 ccagtttatg gtgtatgacc ttgatggtga cggaaaagca gaagtggcaa tgaaaacggc 770941 agacgggaca aaagacggca cgggcaaagt aattggaaat gccaatgcag attacagaaa 771001 tgaacagggg cgtgtgcttt caggccctga atatctcact gtgtttcaag gttcaaccgg 771061 gaaagagctt gtcaccgcaa attttgaacc ggcgcgcggc aatgtgtcgg attggggaga 771121 cagctacggc aaccgtgttg accgttttct cgccggcatt gcctaccttg atggacagcg 771181 gccgagcctg atcatgacca gagggtatta cgctaaaacc atgctagttg cctataactt 771241 cagggacgga aagctgtcaa agctttggac gctggactcc tcaaagtcag gaaatgaagc 771301 gtttgccgga caggggaatc acaacctgag catcgcggac gttgacgggg atggaaaaga 771361 tgagattatt ttcggctcaa tggctgttga tcatgacggg aaaggcatgt actcgaccgg 771421 cttaggccat ggggatgccc tccatacagg agatcttgat ccgggccggc cggggcttga 771481 ggtgtttcaa gttcatgagg acaaaaatgc aaaatacggc ttatctttcc gggatgctgc 771541 aactggaaaa atcctttggg gcgtttatgc cggcaaggat gtaggccggg gaatggctgc 771601 tgatattgac ccgcgttatc cgggacagga ggtgtgggca aacggttctc tctactcagc 771661 gaaaggggtc aaaatcggaa gcggggttcc gtcctcgacc aacttcggca tctggtggga 771721 cggcgatctg ctccgggaac agctggacag caaccgaatt gataagtggg attatcaaaa 771781 cggcgtatcg aaaaatatgc tgactgcatc aggcgcagcg gctaacaacg gcacaaaagc 771841 aacaccaacg cttcaggctg atctgctcgg tgactggcgc gaggaagtgg tgtggagaac 771901 ggaggacagc agtgctctgc gcatttacac gacgaccatt ccgactgagc acaggctgta 771961 tacgctgatg cacgatccgg tgtaccggct tggcatcgcc tggcaaaata tcgcctataa 772021 ccagccgccg cacacaagct tctttttagg agacggcatg gcggaacagc caaaaccaaa 772081 tatgtatacg ccttaactga aagggggaag gaacgggctg cgcgcagccc gttcccatca 772141 aatgaaacca aaaaagaggc aaatggaata cctgaccaga ggtttgattg cggtacagac 772201 agaacagggc gtgtttgtca gctggcgttt tctcggcacg gatcatgaga cgacggcttt 772261 tcacctttat cgggatggaa agcggatcac ccgcgatcca atcgctgaaa gcactaattt 772321 tctcgatcaa aacggaacgg ctgactctgt ttatcaagtg gcggctgtca ataaaggacg 772381 ggaagaaaag ctttccaaga aagctcgtgt ttggcaggaa aatgtcctgg aggttcctct 772441 tgccaaaccg gaaggcggtg tgacgccgga cggaaagccg tacacttaca gcgccaatga 772501 tgccagtgtc ggggatatag acggggatgg agaatatgaa atgatcctga agtgggaccc 772561 gtccaattca aaagacaacg ctcatgacgg ttataccggg gaggtgctca tagatgccta 772621 taaactggac ggcacctttt tgtggcgcat caacctcggc agaaacatca gagcgggtgc 772681 tcattacacg caatttatgg tgtatgacct tgacggtgac ggaaaagcag aaatcgccat 772741 gaaaacagct gacggcacaa cagacgggaa aggacatatc atcggtgatg agcaggccga 772801 ttttagaaac gaacagggca gaattttgtc cggtccggaa tatttgaccg tgtttaaagg 772861 agaaaccggt gaggcgctca cgaccgtgga atatgaaccg ccccgcggca agctggagga 772921 ttggggagac ggctatggaa accggatgga ccgttttctc gccgggaccg cttatttgga 772981 tggggagcgg ccgagccttg ttatggcgcg cggctactat acgagaaccg tgctcgtggc 773041 atacgatttc agaaacggaa ggctcaaaaa acgatgggta tttgactcca accagccggg 773101 acatgaagca tacgcaggac aggggaacca cagcttgagc gtggcggacg tcgacggaga 773161 cggaaaggat gaaatcatat acggcgcaat ggctgtcgat catgacggaa ccggcctgta 773221 ctcaacgggc ctcgggcacg gagacgcgat gcatgtaggg gatctggacc cgtcacgaaa 773281 agggcttgaa gtgttccagg tgcatgagga cgccacgaag ccgtacggac tgtcgctgcg 773341 agatgccgga accggtgaga tattatgggg cgtccatgct ggaactgacg ttggccgggg 773401 catggcggct catattgatc caagctacaa aggatcgctc gtctggggaa ttgatccgcc 773461 gggcaatgat ggcatgtcgt acgggctttt cacgagcaaa ggcgaaaaaa tcagcgacaa 773521 agcgccctct tcagccaatt tcgccatctg gtgggacggt gatttggtca gagaactgct 773581 tgatcatgac tgggacggaa cgatcggcag gccaaagatt gaaaaatggg atgctgaaaa 773641 cggctgtctg aagacgatat ttcagccggc cggcgtgttg tccaacaacg gcacgaaagg 773701 aaacccggtt cttcaggcca acctgttcgg agactggcgg gaagaagtga tatggagaac 773761 ggaagacagc agcgcgctcc gtatctatac aacaacacat ctcacccgcc actgctttta 773821 cacgctgatg catgatccgg tttacaggct cggcatcgcc tggcagaata ccgcctacaa 773881 ccagccgccg cacacgagct tttacctcgg aacgggaatg aaaaaaccgc cgaagcccgc 773941 cctgtacata gcgggaagca aagcggaggc gccgctgtag gaggactaag ggataagacg 774001 caaaggctga acgctacgcc aagatgatta gagaactggc aggacgaacc aatgctcaag 774061 cgctgtacgc accggttttt tcaagggaag agctatccgt gatggaagct gtataaaaaa 774121 cgaggaggaa tgaaaaaatg gcaaatcata tttatcttgc cggcgattcg actgttcaaa 774181 cgtatggaga cagcacaaat caagggggct gggggcagtt tctcggctcg catctgccgg 774241 agcatattca agtgatcaac agagcgatcg ggggaagaag ctcgaaaaca tttgtggaag 774301 agggcaggct tcaggcaatc ctcgatgtga ttgagccgga tgattggctg ttcgtgcaga 774361 tgggccataa tgacgcgtca aaaaataagc cggagcgcta caccgagccc tatactactt 774421 ataaacaata tttaaagcag tatatcgcag gcgcgcggga aaaaggcgcc catccgcttc 774481 tcattacccc cgtagcccgc tttcattacg aaaacggcgt gtttttgaac gattttcctg 774541 attactgcat tgccatgaag cagacggccg ctgaggagaa tgtccagctc attgatctga 774601 tggagaaaag tctcgctttc tttactgaga agggcgagga aaaagtgtac acctatttta 774661 tgatttcaga agggattaac gattacacgc attttacaaa aaaaggcgca aatgaaatgg 774721 cgaaacttgt ggcaaaaggc ataaaggagc tcggcctgcc attgacagaa tcgatcatca 774781 aagaaaggtg aaaatgtgat gagaaaactg tatcatggcg cttgctatta tccggaatta 774841 tgggatgaag agacgattca gcaggacatt gacatcatgc gtgaagttgg cgtaaatgtt 774901 gtgcggatcg gcgaatttgc ctggtcagtc atggaacctg aagaaggaaa aattgacgtc 774961 ggttttttca aagaaatcat cgcccggctg tatgatagcg ggatcgaaac gattatgtgc 775021 acgccgacgc ctaccccgcc gatttggttc tcacatggcc ggcccgaacg catgcatgcc 775081 aatgaaaaaa gagagatcat ggggcatggc tcccgtcagc atgcctgtac gaacaacccg 775141 tatttccgaa aaaaagccgc catcatcacc acagccatcg ccaaggagct tggccggctc 775201 ccggggctga tcggatggca gctagacaat gagtttaaat gccatgttgc agaatgcatg 775261 tgtgagacat gcttgcgcct atggcatgac tggctcaaaa atcgctacgg ggtaattgag 775321 cgcttgaatg aagcttgggg aaccgatgtg tggagcgaga cctatcagac gtttgagcaa 775381 gtcccgcagc cgggaccggc cccgtttctg catcatgcct ctctacgcac tatgtatcag 775441 ctgttttcga tggagatgat cgcttcgttt gcggatgaac aggccaaaat catccgctgc 775501 tattcagatg cgccgatcac gcataacgga tcagtcatgt tcagcgtgga caatgagcga 775561 atgtttcaga atctcgattt tgcctcctat gacacgtacg cttcgcagga aaacgcctct 775621 gcctttttat tgaactgtga tttatggaga aatctgaaac aagggcgccc gttttggatt 775681 ttggaaacga gtccgtcgta tgccgcctcg cttgaaagct ccgcttaccc gcacgcagac 775741 gggtatttgc aggccgaagc cgtatcgtcc tacgccttag ggagccaggg gttttgctac 775801 tggctatggc gacagcagcg ttcaggcagc gagatttccc acggttcggt tctcagtgcc 775861 tggggcgaac ccaccatcgg ctatcaaaat gtgctggcgg ttgagcgggc aagaaaggaa 775921 atcgagccta ttattctatc gactgaaccc gttcaagccg aggcggcgat gacttactct 775981 gacagagcaa aagcatttat taaaactgag cctcaccggg gactccggca tcgttcgctt 776041 gtgacgcatt tttatgaacg tattctcaac acggggattc accgtgacct tattccggaa 776101 ggcgctccac tggacggcta tcgcttgctg tttacgccat ttgtgccgta tttgtcttct 776161 gaatttatca aaaaagcttc ggcattcgct gaagcgggcg gcatctggat caccgggccg 776221 ctgacaggag gacgcacatg cgagcatacc attcataccg attgcggact tggcgaactt 776281 gagaaaacgt cagggatcaa aacacttttt acctttccga tgaatgagaa cgtgaataca 776341 ggaaaagcgt ttggcatcac ggcgccgctc ggactgtgga gcgcggtgtt tgacacagag 776401 agcggaaaca cccttggcac ggttgaagca ggaccggggg cgggccatgc ttttctgacg 776461 gaacggaatt acggcgaggg gaaaattgtc atgctgggct cgcttccatc cgggaaagaa 776521 ggggatgcga tgctggaagc gctcgtcagg cattatgcgg aggaagctgt tatttccagc 776581 cggtcggatg tgacacccgg cacgatcgtt gccccgcgta taggcgaaaa cggccttgtg 776641 tggatcgttg tgaatatgga tggaaaaggc gggagcgtga cattgccgga atcgggaacg 776701 gatttgttga cgcaccgctt ggaaaaggcg gggagactgg cggtcggacc gcatgaatac 776761 cgtgtgattc aatttgacaa tcacagctga ttctttgtat cgaatcagct tttttctatg 776821 gagggagaga cagatgaaaa agatcaaatg gttatcagga cagccaaagg tgacaagcgg 776881 cgtgacgtgg ggcatgccat ggaaaaaagg agaattaaaa aaaggagacc gtctggcgct 776941 tatgaatgaa aacgcggaaa cgcgatatgt gcaaagcgaa ccgtcggcct attggccgga 777001 cgggagcatc aagtggacga agcacgcggc ggtgtttggc ggtcaggaaa accaaagctt 777061 tacagtgcac aaaagagaag tgccgcagcc aactgaatcg ctcagcattc ttgagacaga 777121 gcatgatatc caagtggata caggagcact cgtttgtacc attcataaaa caggatctga 777181 tttcattcaa tcattgcaga tcaatggaaa gccgatcgcc gcaggcggga ggctcgttgc 777241 gataagagaa acgagaaaag agtcagcggc gaaaatggtt cttttgcatg aaaggtctgt 777301 cagctttatc aaacgggcgg cgattgagca gagtggtcct gtcaaagcag tagtcaaaat 777361 cgagggagtg catgtgcttc ataaaacgta tgaggaatgg ctgccgtttg tcatccgatt 777421 aacgttttat gccgggctgt ctgagatcgg ccttgtgcac acgcagctga ttgacaggag 777481 cggtaaacta gaattcgtta aggggctcgg catcgaattc gacctttttt tggagggaga 777541 gccgtacaac cgccatttcc gctttgcggg agagaaaggg atgtataaag aacccgccca 777601 gctgtttggc acacgtaaat tcaatgaacg atatccgctt tatgaaaaac aaatcaatgg 777661 cgaaatgctg tctccagatg aagagcataa ggaatggttt gcacatggca cacagaatgc 777721 ggtttgggac gatgtcaaga tcgtgcaaga ttccagcgat cattacagcc tgtcaaaacg 777781 gaccggaaaa gattatgcgt gggttggaat gctgcatggc agccgggcga aggggctctg 777841 ctatgcgggc ggaaaaaatg gcggtgtggc tctcggcctg cggtatttct ttgagaaata 777901 tccttcagca ctggaaatca caggtcttgc cggcagccgc cccaaaatga ctatctggct 777961 ttggcctccg gacggcgaag cgatggattt gcggcattat acaggaaaca ctcacgtggc 778021 cagcgcgtat gaaggctttg atgaaatgcg ctctgatccg acaggcattg cgaacacaaa 778081 tgaaataagc ctggcgtgct tttcgcacat gccgtctgac gaagtcctca atgcgctggc 778141 tgacaaatgg caggcgcccc cgctcattgt atgcgagccg gacgtctatt acgaatcaaa 778201 agcactcggg gtatggagca tcattgacac atcccatccg ctcaaaaaag agctggaaga 778261 acagcttgat gcggcctttc tgttttataa aaaggaagta gagcaacgca gatggtacgg 778321 tttttggcat tatggcgatg tcatgcatac gtatgacccg atccggcata tgtggcggta 778381 cgatctcggc ggatacgcat ggcaaaacaa tgagctcgtt ccgaccctat ggctgtggca 778441 ggcgtttttc cgctcaggca gagaggatat cttccgaatg gcagaagcca tgacccgcca 778501 tacgagtgaa acggacagct ttcacctcgg tgaatatgcc gggcttggct cacggcataa 778561 tgttgtgcac tggggatgcg gctgcaagga agcgagaatc agcatggccg ggcttcataa 778621 attctattat tatctgacgg gtgatgaccg gacgggagat cttttgacag aagtgaagga 778681 tgccgattat gcccttgtca aaaccgatcc gatgcgcgct ttttacgaga aaggcaagca 778741 cccgactcac gccagaacgg gaccggactg ggcggcgttt tgctcgaact ggctggcgga 778801 atgggagcgg accgaaaatt cggaatatct caaaaaaatc gaaacgggaa tcaactgtct 778861 gaagcggctg ccgctccgct tattatctgg cccgacattt gaatatgatc cggcgacctc 778921 gatgcttcat catatgggag acggcattgc gggcggatat catatgatca ttgccttcgg 778981 cgcgccgcaa gtgtggatgg agctggctga gcttcttgat gactgggaat gggaggatat 779041 gctgagtgaa ttcggcgaat tttacacact cagtgatgag gaaaaacgaa aaaaaagcgg 779101 aggcgctctt catgacgggc attttcactg gccgatgttc gccgccggta tgacagccta 779161 cgccgcaaga aaaaagcaag atcctcatct cgccgccaaa gcgtggaatc ttttgctaga 779221 agataagctc agccatacgc cgcttccgat caaaccggag cgcatcgaga catggacgca 779281 gctagaggag cttccatggg tgacaacgaa cactgtctct caatggtgtt taaatgtcat 779341 agcggcgctg gaactgatcg gagattccct tccggcaaaa aaagaaacat cgggcaaaaa 779401 aggataacag ccggaatttc ataggagaaa tggtgcaaaa aatgaagatt gcaagaattt 779461 atgtaagcgc tttatattga gaggggcaaa ggggaaatgc aaattgaaaa aagggggact 779521 tacgcaacat gaaaataaga atgcgaaaaa aatggatggc cttgccgctt gctgccatga 779581 tgatcgccgg atgcagccat tcggaaacat ccaattcagc aagcggttcg aaagatacga 779641 tcaaaattat ggcgccgctc ttatcgccgg aaagcccaag tgataagagc ccttcattaa 779701 aagcgctcga aaaatacaca ggcaaagaga ttaaggtcac atgggtgcct gattcatcct 779761 acaacgacaa attcaacatc gtcatggctt caggagagat gcctcacgcg attgtcatta 779821 aagataagtc agccggcttt atcaaatctg tcaaagcagg ggcgttttgg gagctgtctc 779881 cttatttaaa agactacaag aatttaagcc aggcagatga aaagattttg aagaacagct 779941 cggtgaacgg cgaggtgtac ggaatctaca gaacgaggga tctgatcagg gcgtgtatga 780001 tcatcagaac cgactggctg aaaaatgtcg gtctggatat gccggaaacg cttgatgatt 780061 tctatgaagt gctgaaagcc tttaaggaaa aagatcctga cggaaacggc aaggatgata 780121 cgtacggcat ggtcgtgccg aaatggatgg gactcggcaa cggaagccca tgggatgttc 780181 tgcaaatctg gttcggcgct ccgaaccgct acggtgttga aaacggaaag ctgattccag 780241 attttacaac gaaggaatac atggatgcgc tcacgttttt taaaaagctc tatgatgagg 780301 gcttgatcaa taaggacttt gctgtcatgg attctgcgaa gtggaatgat ccggttgtaa 780361 aaggaaaagc gggtgtcatc gttgatacag gctcaagagc gtctcaaatc caaagcgcga 780421 tggaggaggc ggatgagtcg aacaaggata tcattgatat cgtcggctcg cttgagggac 780481 cgaatggcaa gcgcaccttc ccgacatctg gttattcagg catgatcacg ataccaaaat 780541 caagcgtcaa aaccgaaaaa gagctgaaag aggtgctgtc cttcctcgat aagatgaatg 780601 ataaggaagc gcagattctc acgaacaacg gagtgaaggg ccgcaattac gagctcaagg 780661 acggcgtatt cacctcactt gaaaaaaaca ataaatctct cctgtatgag catgaaggct 780721 tggcacagtt cagcatgtcg attccgaaaa gcgagtatta catcgaagac cagaaaacca 780781 agctcttcca gcatcgcaag gacatcataa ccgaaggaga aaaaatagcc gtctttaacc 780841 ctgctgagtc gcttgtatct gatgtctata cccaaaaagg agcccagctt gacaacatca 780901 tcctcgacgc gagaacacaa tttatcattg gagaaattga tgaaaaaggg ttcgatgatg 780961 cggtggagct ttggaaaaaa agcggcggca atgaactgat gaaggacttg aacaaattgt 781021 accaatcgtc aaaataaacc gatgcgcctg cctttcggcg ggcgccccgg tatcacgaaa 781081 ggagaacaga tatggaaaca gtgccgaaga agagagatgc acctgttctc accgctggaa 781141 aaggcatcag ctggatggct gcgctcaaac gggacaaatg gctttatctt cttcttattc 781201 ccggtctgct ttatttcttg attttcaaat acttgccgat gtggggtgtg ctgatcgctt 781261 ttaaagacta ttcgccatat ctcggcttct ggaaaagcga atgggtcggc tttgattatt 781321 tcaaagactt ttttatgaat ccggattttt tccggctgct gcgcaacacc ctcatgctgg 781381 cgagtctgga tcttttgttt gcctttcccg cgcctctcat tttggctctg cttttgaatg 781441 aggtaagaaa ggccgtgtat aaaagatgta tccaaacctt tatttacgta ccccattttg 781501 tatcatggac aattgtggtc agcatcacct tcgttttctt tactgtcgat acaggtgtga 781561 tcaacaaatt gattatgagc ctgacaggtg agcagatttc tttcttgtcg gatgcagact 781621 ggttccggcc aatgattgtg atgcaaagca tttggaagga gacaggctgg ggaacgattc 781681 tatttttggc agcgcttgct acggttgatc aagagcagta tgaagcggcc atcatggacg 781741 gagcggggcg gttcaggaga atgtggcata ttacgctgcc ggcgattaga agcaccatta 781801 tcgttttgtt gattttaaga atcggcagct ttttgaatct tggctttgaa caggtgtatt 781861 tgatgacgaa ctcactcaac cgcagtgtgg ctgacatctt cgacacgtat gtgtacatga 781921 tggggattac ccaaggggcg tatagctaca gcacggcggt cggtttgttt aaatcagttg 781981 tcgggattat cttgattttt ggcgccaatt acattgcgaa aaagtttgat caggaaggat 782041 tgttttagag gagggagagg tatggctgaa attcacacga tgcacaacac caaagccgga 782101 cgggtgtttg acgtctgcaa cattctgttt ctcggcggtg tcggcgcgat taccattttg 782161 ccgtttttat atattatcgc cggttccttt gcgacagaag cggaactcgc ccagcggagc 782221 ttctttattt tcccgaaaac ctttacactt gatgcttaca agtatgtgtt ttcgacaccg 782281 acgttccttc gaagcatggg cgtgtccatc ttcatcacgg tggttgggac ggctgtacag 782341 ctgtttttta ccttcacgat ggcgtatccg ctggcgaaac ggcatgtgaa gggacggaat 782401 ctgctgttga atctggtgat tttctccatg ctgttttcag gcggcatgat tccgacgtac 782461 cttgtcgtaa aatcacttgg ccttttggat acgtattggg cattgattct gccgatggcg 782521 attaatccgt tcaaccttat tattatcaaa aacttctttc agcagctgcc gcgcgagctg 782581 gaggaatcag caaaaattga cggctgttcc gaaatcggcg tcttctggcg gatcgccctg 782641 cctctgtcaa agccagttat tgcgaccttt gcgctgtttt atgcggtcgg gatttggaat 782701 gatttcttcc acgctctctt atatatcaat gacagtgcaa aatggccgct gcaaatggtg 782761 cttcgccaag tcacaatttt atcggattta acggcgacca atggtgatac gatgcaaaat 782821 gcagttccgc cggagcaggg aattaaactc gctgtcattg tcattgcgac gctgccgatt 782881 ttggcggtct atccattttt acaaaaacac tttgcaaaag gaatgctgat cggttcggtg 782941 aaaggctgag aaagggagtg tttcatatca gtacattaga tcagattaag attgcctata 783001 tcggcggggg gtcccaaggc tgggccagaa gcctgatgag tgatttgtcg attgatgaac 783061 ggatgtcagg cacggtggcg ctctatgatc ttgattttga agccgctcag aaaaatgaag 783121 tgatcggcaa tcacagcggg aacggcagat ggagatatga ggctgtttct actttgaaaa 783181 aggcgttatc agccgcggat atcgtcatta tttccatttt gccgggatca ctggatgata 783241 tggaagtcga tgtgcacttg cctgagcgct gcggtattta tcagtctgta ggtgatactg 783301 tcgggcctgg agggatcatc aggggcttgc gtgctgtgcc gatatttgcg gaaattgccc 783361 gggcaataag agactacgca cctgaatcat gggtcattaa ttatacaaac ccgatgtctg 783421 tctgtacaag agtgctgtat aaagtgtttc ccggcatcaa agcgattggc tgctgccacg 783481 aggtattcgg gacgcaaaag ctattggcgg aaatggtcac ggaaaggctg gggattgagg 783541 tgccgcggcg tgaggatatc cgcgttaatg tgctcggcat taaccatttt acatggatca 783601 caaaagcctc ttaccgccat attgacctgt tgcctatatt ccgtgaattc agcgcgcact 783661 atggggaatc aggatatgag ctggaggggg aatgctggag ggacagcgtc ttttgttcgg 783721 cacaccgtgt tgcgtttgat ttatttgaaa cgtatggcgc catccctgct gcgggtgaca 783781 ggcatctggc agagtttctt cccggcccat acctcaaaca gcctgaagta tggaaatttc 783841 atctcacacc tatatcattc agaaaacaag acagagctga gaaacgacaa gaaacagaac 783901 ggttgatcgt gcaacaacgg ggcgttgctg agaaagcttc gggagaagaa ggcgtgaaca 783961 tcatagcggc tcttctcgga ttgggtgaac tcgtcacaaa tgtaaatatg ccgaatcaag 784021 gccaggtctt aaaccttcct atacaagcca ttgtcgaaac aaacgcattc atcacaagga 784081 accgtgtcca gccgattttg tccggagcgc ttccgaaagg tgtggaaatg ctggcggcta 784141 ggcatatatc caatcaggag gcagtggcgg acgcaggttt aacaaaggat actggcctcg 784201 cgtttcaagc cttcctcaat gacccgcttg tccagattga ccgcagtgat gcagagcagc 784261 ttttcaatga catgctccaa tgcatcatgc aaagctgagc ttgccgatta gctctttccg 784321 gtttagaaag gaaagcattg accatactga tagtataatc aagaagtagg tgctatcaat 784381 atgggaaatt atttaagtgt tgcggtagaa ctggtctgcg gtttaggcat tttatttatc 784441 atcttaaagc ttctcgggaa aacccaattt tctcaaatta cgccgtttga ctttatttct 784501 gctttaattt taggtgaatt ggtcggaaat gccgtctacg atcatgaaat caaaatcaaa 784561 gaaattattt ttgcttcgct attgtggggc gtgctgattt atattattga atttatcacg 784621 caaaaaatga aatcatcgcg aaagttcttg gagggcgagc cgaatatcgt catccgcaaa 784681 ggggagcttc aatataaagt aatgaagaaa aataagatag acattaacca gctgcaaagc 784741 ctattgaggc aagctgggag cttttcgatc caagaagtag aatatgcgat tcttgaaaca 784801 aacgggatgg tcagcgtgct tccaaaatca gactttgaca aaccgacaaa taaggatttg 784861 cagattcctt cgaagtccgt ttctctgccg atcacgttaa tcatagatgg agagattgtg 784921 cgggataatt tgaaggaagc aggtgtggat gaacagtggc tgaaacaaga attgaaaaag 784981 aagaacattg ataagacaga ggacgtgtta tttgcagaat ggcataaaaa taagccgctg 785041 tatactgtaa cgtacgaaca aagcagatca acatgactct tagaaaaaag cttgcagcaa 785101 ggcgcaagct ttttattgat tgtatgtccc ttgtttgaca gcacgtacat ggtacatgct 785161 cacttcagtg ctgatcagat agtcaggctt tggtttgcct ttgtttgctt tatggccggc 785221 gatatgcgca tcgctttttt cccattgctt ccagtgatcc tctgattccc agcgaatcat 785281 gacaacaact tcttcatcac cgcggcgcac atttttctca agcactgtca catcaattaa 785341 accttcttgt ttttcaatga ttccttcagc gctgaaacgt tctatgactt tatctgcaaa 785401 gccttcttta accgtcattt ttctcaactg tacaaacatt tgtctcactc caatcattct 785461 cacatatgaa taattgtaaa tgaaattcat tctcaatgtc aaagaaagcg cagggcggaa 785521 tcgaaccgcc gtgcgcaaca gtttattctt ttaataaaaa cacatttccg tcttcgtcct 785581 taaattgaac gaaggtgccc cactccattt gattgggctc accgagaaat tctacaccgt 785641 ttgtcttcat tttctcgtat gtaccaaaga tgtcttcgca ttcaaacaca atagaagcct 785701 tcatttgctc tgagcctttc atcatggctt tcgggtaaat gactaaacga gtctcggctc 785761 cttttggcgc aacctccagc cagcttgctt caggtcccat tgggtgatcc gctgcaatat 785821 caaagcctac cttctctgtc caaaattgct tcgctttctg ctggtcctcg acatatacag 785881 caacagtgcc aatttgtttg atcataggga aacctccaag ttgaaaagat aataatacta 785941 taacctgttt acggccgaag taacataaaa aaatcagccg ggaaaccggc tgattattaa 786001 aatgagcagc ttacaacatc gatgtgattt gtgtctaagg cgaaataaac ccagcggcgc 786061 cgtgaggaat cccaataaaa gccgccgacg gatcttctgc caaggatgat cgggtaaaac 786121 caaaatgagc ggccattggt taaccagaca taggtaaatc ggaaaaggca aggacgaatg 786181 gtgattggtt caactaacaa aacggctcct tgagaaccct gcggttttgg gggtttcgct 786241 ggtatttggg aaggaggagg tccctgcggc gcaccgccga agcctgggct ggcaccgctg 786301 ccaataccag ggccggagcc gccgccaaag cctggaacag caccaccgcc aatgccagga 786361 ccggagccgc cgccagagcc cggaacagcg ccgctgccaa tgccaggcca tggatatcgg 786421 tattcatatt caaaagcagg ccaaggctca taaaaatgcc ccgcaaacat ataaggatca 786481 acataataca tgtgataacg tcctttctca ttgtaaactg tacattgcag tttatgcggg 786541 cggactctta ttggtgcatt cgcctaagga tatgaagctg gaatgctctc agagagcaga 786601 atcatttgat ttttctctag tcttattcac aattccgatt tatcatttta taatgaaagt 786661 gcttctatta cgaaaaagga gacagaccgt gaatatcgat caattattat atcaatatat 786721 catagacaac actgcggata ttactgagaa atggttcagt ttgcgttgcc agctaaaagg 786781 cgagctatat tccgccagcc atttaagtga agaaacgaaa acacttttaa ccgagcagca 786841 tacatttacc aatataacaa tcgcaagcgc atttctggag gatcaaaccg attttcaaga 786901 aaacatgaca aaatgggcgc aaaacgttgc gaaaaacagg gtagagcagg atgttcaagt 786961 gcatgaggtc gtagaagcca tatccaattc aagaatctca ttctgggacg cagtcgccac 787021 atttataaaa gagaatcagg agattgtgac aaatgaggat gcagaccgat ggaaccgcat 787081 tgtgaatcag tcgttcgata agctgattat tgaattctcc gagcagtacc aaaaattcat 787141 gctgatgagg cttacatctc agcaggaact gatctcagag cttggctgcc cggtcatttc 787201 cattgccgat ggaatcggga tattgccgct tatcggctcc attgatacaa aacggcacag 787261 gtcattttag aaacagtgcc ggtccgctgt gtcgagagaa aaatcacaag cctcgtcgtt 787321 gatctttcgg gtgttccgat tgtggatacc atggtggctc agcaattgta caacctgtct 787381 aaaacacttt tcttattagg cgtcaaagcc gtattttcag gaattcgccc ggatgtggcc 787441 caaacatcga ttcaattggg gcttgatttt agtgaatatg aaacgtacgg cacgctgaag 787501 caggcattag aaaacatggg tgtccgctgt attgttgagg aattggaaga aaacaaatag 787561 gaagtttcca ggcatatgat tgtccgtcac cgggtgatca tatgcctttt tgatttgaac 787621 agaaatcacc attgatttat cgaaaaaaac ataatattat aattcttata agaatactgt 787681 gaattaaaac ctattcaaca ggggggaagg tcttttggtt tctaaatcaa cgattgatcc 787741 ggaagtgatt gaaaaaatca tcagctcgct ggaaacactc gatttcggca cggttcagat 787801 tacggttcat gattctcaga ttacccaaat tgagaaaata gaaaagcacc gtttttcgct 787861 gaaaaggaaa gaatcaaaat gataatgtaa agggcgtttg ttttcattaa attctcctta 787921 aaacatatac atatttcatc caatttttat ataatagacc tttaagatca ttttttagga 787981 ggatttttga catgcaagct acggttcacg agagtaagca atcgatcatg caacgcattt 788041 tgacagtctt tgtcttcaca ttgctgatcg cgactgtcgg cctttttatc ggccaatttg 788101 ttcctgtcgc tttgatgctg ccgctttcta ttcttgaagt ggcgatgatt attctggcct 788161 tctggatgcg cagaagaaaa gcggtcgggt atgcgtttgt atatacattc gcgttcgttt 788221 ccggcattac cttatttccg atcgtcagcc attacgcttc catcgccggc gcctatgtcg 788281 tgctcgaagc ctttggctct acatttgtca tttttgccgt cttgggcaca atcggcgcaa 788341 aaatgaagaa ggatttatcc ttcctgtggt cgtttctgct ggttgcggtg ctcgcactcg 788401 cagtggtagg gattttcaac attttcagcc cgttaaactc agcggcgatg atggcgtatt 788461 ccgtgatcgg aaccatcgtc ttttcccttt acattttgta tgatttgaac caaatcaagc 788521 accgccacat tacggaagac ttgattccgg ttatggcgtt atcgctgtac ctagacttta 788581 tcaacttgtt catcaacctg ctccgcttct tcggcatttt gagcagtgat gattaatgaa 788641 aaagcgtctg tcattggata ggcgcttttt gccatacatc aaaaaggcag gtggagtatt 788701 ggtgaaaaaa caaatgggcg catatgtatc tctggcagca gctatggcga tcgtcggcag 788761 ttctgtcgtt gtcggcaagc tgatggtcga acggattccg gtctttcttt cctcaggatt 788821 gcgttttttg atcgcttctg tcgtattgct catgctgctg ttttgcattg aaaaagggtt 788881 tccggctttg acgaaaaaag atgtgttcgt attactggtg caatcattca caggcgtgtt 788941 tttgttcagt atttgcctgc tgtatggggt tcaatatacg acgggaacgg aaagcggcat 789001 tttgacaagc acaaccccca tgttgatcgg tattttatcc tttttcctgc tgagagaaaa 789061 aattgagaaa aagacgctga tcggcatttt gctggcggtt tgcggcgtaa tggcgattaa 789121 tttgtttgga gccgggagcc aagacgggac gccgcacgcc ttattcggga acatgctgat 789181 cattgctgca gtcattggcg aagcgttgtt tacattgatg gccaagctgc tatccccgca 789241 tatttcggca ctggcgattt cgaccttcgt atcgctcttc ggcttcctgt tttttctccc 789301 gtttgctttg tttgaggcct cttcatttga ttacagcgtg ccgactgttt tggattggtc 789361 gtatgtgctg tattacgcgc tttttgtcac tgttttggcg ttttacttat ggtatagcgg 789421 ggtgacgaag gtgccggcgg gtgtatcggg cattttcaca tccgttcttc cggtctcagc 789481 tgtcattttg tcaggcgtga tattgaagga gccatttgag tttgtgcatt tcatcggcat 789541 tgcatgtgtc atcggcggca tatttgttac ggtcataaag aaaaaacagc cggatgcgta 789601 tccggctgca gaagaaaaga cgctatagcc tgtccggatc ggacgggttt tttagtcttt 789661 aaacacgctc agcctttcaa aaagatcacc aagcatcttc acgaacatgt ctttttcctc 789721 gtcgctgtag ttttccatga cagcggatat tttgctgaaa tggccgggca gaaattgctc 789781 caggcgtgct ttgccttctg ttgtcagttc aatgctgatt tttcgtttat cctctgtgtg 789841 atgcctgcgg ctgacaaaac cgtctctcgc cagcccgtct agcaggcctg taattgttgc 789901 tttcgtgaca tttgaccgct tggcaagctc tgtcggactt aacctatgat ccttggcatc 789961 aaagagcagc atcaggattt tgaattttcc ttctgaaagc cctcggccag caaagtaatg 790021 ctccatcaca tgattcattt tttttgaaat atcaaaaaga gataaaaaca attcaagaga 790081 gccggcgtca atattggcat acgtttcggc gtgctctgtt atatgcttat atttcggtaa 790141 atgttttaat tccatcgcaa ttagctcccg tacattcgtt gtgacacgat tataaaggag 790201 ggaaaaccat aacgcaactt ggcttggaga tgattgacag cttttcttgg gacatagtaa 790261 ggtaatatag ttaggcgcct aactaataca tatagagctg aaaaggtggt tattgatatg 790321 aaacatatgt taatagcagg aggcggaatc ggcggcttgt cagcggccat ttctctccgt 790381 aaggcagggt tttccgtcac cttatgtgaa gcggcttcag aaaatcgaaa aacaggtgcg 790441 gggattcttc agccgcaaaa cgcactggcg gtgttgaaag aactgggcgt attcgaagat 790501 tgctgtaagc acggctttca aacagaatgg tttaaaacgt ttgatgaaca ggggaatttg 790561 ctgtttcaag tcagtgaatc ctttttagac gattcacttc cgggacgcaa taatatcctg 790621 cgcaaaacgt taaatgacat tctcatgaag catgccgagg cagtgggtgt agacatcaag 790681 tgggggaaaa aggttgtcgc ctatgaagaa actgctgaat cggtcactgc cttatgtgaa 790741 gatggagaaa agatgcaggc tgacattctg gcgggctttg acggcattca ctccgttgtt 790801 cgtgataaga tgctgcaaaa ggaaacggaa aaagagcatc tcggcatggg agcgtggcgc 790861 ttttatatcg aacttcctga ttacacattc gaggacgcaa cattcatgta tagaagcgga 790921 gacacacaaa tcggggtggt gccattggca caacacgctg gctatgtctt cgtcctccag 790981 ccttgcacga gcgattactg ggatgaggaa gatacccggt ttgatagagt aaaagagatt 791041 ctttctggtt ttcgggggct ggattttgtc acaaagcaca tgtcaaaaca gcatcctgtc 791101 atctttaaca aactggagca ggtcgccgtg caggagccat ggcataaagg ccgcgtcatc 791161 atcggaggag acgccgccca cgccggtgcg ccaaccctgg cacaaggagc ggcaatggcg 791221 atcgaggatg ccatcgtcct cgccgaagaa ctccaaaacc acgccgacca cgaaacagca 791281 ttacaggcgt actataaaag aagagcccca cgagcgctca aagtccagaa cctatcatct 791341 gaaatcgtcc gccgcaggct gaaaggagag ccgggagcgg aagaactgat tggggagtgc 791401 tatgcggtgt tgagggaagg gtattaaata ggaaaagtcc agaaagtgat ttctggactt 791461 tttagtcttg ctctgtttta ttccttatcc gctcaatcac ctcatgcagc ccctcaggct 791521 tataaaactc caccggtgaa ctgcctttct caaacgaaat cgtctcggct tcaatcagcg 791581 cgacatagcg cccgtttact tttgcgagat gaatagaatc gccaaaatcc gctagcaatc 791641 ccttaatctc tgtttctccg actttcattt tcagctgggc ctctggcgtg tgctcgatga 791701 tttgggcgga ggcttcgatg acttgatggg tgtcgaggcg ctcttggatt tcccgttttt 791761 cgcttgcttc ccaaatctca atgtcgtgct cgaactgctt gagttcttcg ctgttgtctt 791821 caaatgtctc gtagacgtgc tcttgtacca tgttcatgac ctgatttttc atgatttctg 791881 gcatcgattc tccgtactcg acgaatttca gaaagtcctc aaaatagcgg gcgtgcgagg 791941 cctggtggat tttcagttca ccttcctcga ccattccttc ctctggcatg tacgggtatt 792001 ggatgctttt catgtttttt gtcgtgatcg ccatttcgac ttttttaatg agagaagacg 792061 cgtcagagat gcgggcgacc ttcggctcaa aatcacattt cataatgaag acaaatgact 792121 catcaaagta ttttctcggc acggccgaag cgacgagaaa cacgccgccg cgaaccgcgc 792181 ttgtgtcaag gtacgtgcgg acgaactgct cgctcagctc attgaagtct tcttttgttt 792241 ccgccagacg cgcgcggttg aacatgttgt agtttgggtt ggaatcgagc tcgtggccgg 792301 gctcgacgat aaaatggccg attttcgtcg gcacctgctc ggactgcgga tggcggtcgg 792361 ctttccgttt aacgattttt ttcagttccc cgtcgagaaa gtccttcagc tcgctttctt 792421 caaattctcc cgtatcaagg gtctggaagt gcttgaactg cttgttcgcc tgctcatctt 792481 tgccttccac ctgtatgaca taaaaggata aaaaccgaat ttcaaaatcc atatataaac 792541 tcaccttatt cgcgtattgt acagcttctc aagtatagaa aaaacagcga tcatgcgtca 792601 attgggagaa cggaataatc atgaccatga aagggaaatg tagtcaaata gaaggcattt 792661 catacggaaa ggaatggttc gatgaaggaa acaagcccga ttcctcagcc gaagacgttt 792721 gggccgctcg gcaatttgcc tttaattgat aaagacaaac cgacgctttc gctgatcaaa 792781 ctggcggaag aacagggccc gatttttcaa atccatacac ccgcgggcac gaccattgta 792841 gtgtccggcc atgaattggt gaaagaggtt tgtgatgaag aacggtttga taaaagcatt 792901 gaaggcgcct tggaaaaggt tcgcgcattt tccggtgacg gattgtttac gagctggacg 792961 catgagccta actggagaaa agcgcacaac attctgatgc cgacgttcag ccagcgggcc 793021 atgaaggact atcatgagaa aatggtcgat atcgctgttc agctcattca aaaatgggca 793081 aggctcaacc cgaatgaagc agtcgatgtc ccgggagata tgacccggct gacgctcgac 793141 accattgggc tatgcgggtt taactaccgc tttaacagtt actacagaga aacgccccac 793201 ccgtttatca acagcatggt gcgggcgctt gatgaagcga tgcatcaaat gcagcggctt 793261 gatgttcaag ataagcttat ggtcagaaca aagcggcaat tccgctatga tattcaaacg 793321 atgttttcgt tagtcgacag cattattgca gagcgcaggg cgaatggaga ccaggatgaa 793381 aaagatttgc tcgcccgcat gctgaatgtg gaagatccgg aaactggtga aaagctcgac 793441 gacgaaaata tccgctttca gatcatcacg tttttgattg ccggccatga aacaacgagc 793501 ggcctgcttt cctttgcgac ttacttttta ttgaagcatc ctgacaaact gaaaaaggcg 793561 tatgaagagg tcgatcgggt gctgacggat gcagcgccga cctataaaca agtgctggag 793621 cttacataca tacggatgat tttaaatgaa tcactgcgct tatggccgac agctccggct 793681 ttcagccttt atccaaaaga agacacagtc attggcggaa aatttccgat cacgacgaat 793741 gacagaattt ctgtgctgat tccgcagctt catcgtgatc gagacgcttg gggaaaggac 793801 gcagaagaat tccggccgga acggtttgag catcaggacc aagtgcctca tcatgcgtac 793861 aaaccattcg gaaatggaca acgggcctgt atcggcatgc agtttgccct tcatgaagcc 793921 acacttgtgt taggcatgat tctaaaatat ttcacattga ttgatcatga gaattatgag 793981 cttgatatca aacaaacctt aacacttaag ccgggcgatt ttcacatcag tgttcaaagc 794041 cgtcatcagg aagccattca tgcagacgtc caggcagctg aaaaagccgc gcctgatgag 794101 caaaaggaga aaacggaagc aaagggtgca tcggtcatcg gtcttaacaa ccgcccgctt 794161 ctcgtgctgt acggctcaga taccggcacc gcagaaggcg tcgcccggga gcttgctgat 794221 actgccagtc ttcacggcgt aaggacaaag acagcacctc tgaacgaccg gattggaaag 794281 ctgccgaaag agggagcggt tgtcattgtg acctcgtctt ataatggaaa gccgccaagc 794341 aatgccggac aattcgtgca gtggcttcaa gaaatcaaac cgggtgagct tgagggcgtc 794401 cattacgcgg tatttggctg cggcgaccac aactgggcga gcacgtatca atacgtgccg 794461 agattcattg atgagcagct tgcggagaaa ggcgcgactc ggttttctgc gcgcggggaa 794521 ggggatgtga gcggtgattt tgaagggcag cttgacgagt ggaaaaaaag catgtgggcg 794581 gatgccatca aagcattcgg acttgagctt aatgaaaacg ctgataagga acgaagcacg 794641 ctgagccttc agtttgtcag agggctgggc gagtctccgc tcgctagatc gtacgaagcc 794701 tctcacgcat ccattgccga aaatcgtgaa ctccagtccg cagacagcga tcgaagcact 794761 cgccatatcg aaattgcatt gccgccggat gttgaatatc aagagggcga ccatcttggc 794821 gtattgccaa aaaacagcca aaccaatgtc agccggattc ttcacagatt cggtctgaag 794881 ggaaccgacc aagtgacatt gtcggcaagc ggccgcagtg cggggcatct gccattgggc 794941 cgtcctgtca gcctgcatga tcttctcagc tacagcgtcg aggtgcagga agcagccaca 795001 agagcgcaaa tacgtgaact ggcgtcattt acagtgtgtc cgccgcatag gcgcgaatta 795061 gaagaactgt cagcagaggg tgtttatcag gagcaaatat tgaaaaaacg aatttccatg 795121 ctggatctgc ttgaaaagta tgaagcgtgt gacatgccgt ttgaacgatt tttagagctt 795181 ttacggccgt taaaaccgag atactattcg atttcaagct ctccaagagt gaatccgcgg 795241 caagcatcga tcacagtcgg tgtcgtgcgc ggcccggcgt ggagcggccg tggcgaatac 795301 aggggtgtgg catcaaatga tttagctgag cgtcaagccg gtgatgatgt cgtgatgttt 795361 atccgcacac cggaatcccg gtttcagctt ccgaaagacc ctgaaacgcc aattattatg 795421 gtcgggccag gcacgggagt cgcgccattt cgcggtttcc ttcaagcccg cgatgtttta 795481 aagcgggagg gcaaaacgct cggtgaggct catctctatt ttggatgcag gaacgatcgg 795541 gattttattt accgagatga gcttgagcgg tttgaaaaag acggaatcgt cactgtccac 795601 acagcctttt cccgaaaaga gggcatgccg aaaacatatg tccagcatct catggctgac 795661 caagcagata cattaatatc aatccttgac cgcggtggca ggctttatgt atgcggtgat 795721 ggcagcaaaa tggccccgga tgtggaggcg gcacttcaaa aagcgtatca ggctgtccat 795781 ggaaccgggg aacaagaagc gcaaaactgg ctgagacatc tgcaggatac cggtatgtac 795841 gctaaggatg tctgggcagg gatatagata aagaagactg gagacatcca gtctttttag 795901 tcctttcgaa aaaatggtga tcgcgctaaa cattgatgca tacaataact tcagtccgcc 795961 ggaagggcgg gctgtctgca aaacctattt ttcgtttttg ctagtttatg ttattcttat 796021 actcggtatc tatttctttt ttcaaaggca cacatgacaa aagaaatcct ttttttattt 796081 ccgagaaaaa aatgtgaaac gaaatgaagg tttctttcgt ccagtgattg gtttccaaat 796141 ggttgtaata aaaatgatat ggtgcgaaac ataaatattc cggcttgccg cggtgtattt 796201 attgttgtgt gatgccttga ttttgtttgg aaagaaggaa ttggaaggca ggatataaag 796261 agcaggtaaa tatgaatgaa gaacttaaag tgtttaagaa agtagaggtt gccatgaaga 796321 aacttttttc ttacaaactt agcttttttg tgctggctgt tatactgttt tgggcaaaaa 796381 cgtatttatc ctacaagact gagtttaatc ttggggtaaa aggcacaact caggagatcc 796441 tcctgatatt taacccattc tcaagcgccg tcttcttttt aggactggct ttgctggcga 796501 aagggcgtaa atcagccatt attatgctga ttatcgattt cttgatgaca tttgtgttat 796561 atgcaaatat tttattctat cgtttctttg acgatttctt gacgttcccg aacattaaac 796621 agtccggaaa cgttggaaac atgggagacg ggattttcag tatcatggcc ggtcatgata 796681 ttttctattt cttagatatt atcattttga ttgcggtatt gatctggaga cctgaattaa 796741 aagaatacaa aatgaaaaaa cgctttgcat ctttagtgat cctttctggg atcgcactgt 796801 ttttcatcaa cctgcactat gcggaaaaag accgtccgca actgctgaca agaacgtttg 796861 accgcaatta tattgtgaaa tatttaggtt tatacaacta caccatttat gacggtgtac 796921 agacggctca aacagagacg caaagagcct atgcaagcag cgatgattta acaagtgtcg 796981 agaattacac gacgtctcat tatgcgaaac caaacgccga gtacttcggc tctgccaaag 797041 gcaaaaatat cattaaaatt cacctcgaaa gcttccagtc attcctgatt gactacaagc 797101 taaacggtga agaggtgacg cctttcttaa ataaacttgc gcacggcggg gaagatgtga 797161 cgtattttga taacttcttc catcagacag gccagggaaa aacatctgat gccgagctga 797221 caatggataa ctcgatcttc ggtcttcctg aaggctccgc gtttgtgacg aaaggcgaaa 797281 acacctacca gtcgcttcct gcgattttag accagaagga aggctataca agcgccgtcc 797341 tgcatggtga ttacaaatcg ttctggaacc gtgaccagat ttacaaacat atcggatatg 797401 acaagttctt cgacgcaagc acgtatgata tgtcagatga aaatgtgatt aatatggggc 797461 ttaaggataa gccgttcttt acagaatcga ttccaaagct tgaatctctt aaacagccat 797521 tttatgcgca tttgattaca ttgacaaacc attatccgtt taaccttgat gaaaaagacg 797581 cgtctcttaa aaaagcgaca acaggcgata acacagttga cagctacttc cagacagcgc 797641 gttaccttga cgaagcgctt gagcaattct tcaaggagct gaaggaagcc ggcctgtatg 797701 acaactcagt catcatgatt tacggtgacc ataacggtat ttctgaaaac cataaccgag 797761 cgatgaaaga gattcttgga aaagagatca cagattatca aaacgcacag aaccagcgtg 797821 tgccgctgat gatccgcgtt cctggcaaaa aaggcggagt gaaccatacg tatggcggcg 797881 aaattgacgt catgccgaca cttctgcact tagaaggaat tgattctcag aaatatatca 797941 actttggtac tgatttattc tctaaagacc acgacgatac ggtggcattc agaaacggag 798001 acttcgtaac gccgaagtac acatcagtcg acaatatcat ttacgatacg aagacaggtg 798061 aaaaactgaa agcgaatgaa gaaacgaaga atctgaaaac aagagtgaac cagcagctga 798121 gcctttcaga cagtgtcctg tacaaagact tgctgaggtt ccataaacta aatgatttca 798181 aagccgttga tccgtcagac tatcattacg gcaaggagaa agaaatcaaa taagatgaaa 798241 aagagccttg agcgggcgca ttgccttcgc tcaaggctct ttttttggtt atacaaccaa 798301 cttgaaaaaa tagattccat ttggtcacca aggctggctt tctctcatat cattacagta 798361 gattttgaaa ccggattgaa atcggacaaa ttatcgggga aatgccttga tagattgtga 798421 agatgtacca ggtttcgaac tcaatattca tagagatgag gggtagagat gaaagcggtc 798481 attctctgcg gcggaaaagg aacgagaatg agtgaagtca cgaatgacat tcctaaaccg 798541 ctcgccatga taggcggcaa accgattcta tggcatatta tgaaaattta tcagtactac 798601 ggagtaaacg agtttattct gcttttgggc tataaaggag aaaaaatcaa ggaatacttt 798661 ctcgactatg aatggaagca caacagcctg acactcgaca gctctacggg agaggtacag 798721 atgctggggc agcctgaaac gtggaaaatt acgtttttgg agactggggt agatacgctg 798781 acagccggaa gaatcttgca ggcgaaagac tatatcggtg atgaaacatt tctgctcacc 798841 tatggagacg ggctggccaa tatcaatctt ttccatctca tcagctatca tcagacaaaa 798901 ggtgctgccg cgactgtcac cggcattgac aaagtctcgc agtttggcac cttgacagtt 798961 gaggatggca tggcgaaaac attttctgag aagacatcaa gtgatggaat catcaacggc 799021 ggattcttcg ttcttagtcc aaaggttttc gattatttgc cgaaggacgg gaacacgatg 799081 ttcgaagatg aaccgctgaa gaaccttgcc aaagatgggg agcttgctgt gtaccgccat 799141 tacggatttt ggacggccat cgatacgtat aaaaatctct tagaagtcaa caaaatgtgg 799201 aatcaaggac aacaagtatg gaaggtatgg tgaattgatt tgagtttctg gaaaaataaa 799261 aacgtatttg tcacgggatg cacaggtctt ttaggaagct atttggtgaa agagctgatc 799321 gaacagggcg caaacgttac ggggctagtc agggatcatg tgcctcaatc caatctttat 799381 cagggagaac atatcaagaa aatgaacatc gtgcggggct ctcttgagga cttggctgtg 799441 attgaacgcg cgcttggcga gtatgagatc gacacagtct ttcatcttgc tgcacaagcg 799501 attgtcggcg tggcaaaccg caacccgatt tctacctttg aagcgaatat cctcggcacc 799561 tggaatattc tcgaagcctg ccgcaagcat ccgttaatta agcgggtcat tgtcgcttca 799621 agtgataaag cttacggcga tcaagaaaac cttccatacg atgaaaacat gccgctgcaa 799681 ggcaagcacc cgtacgacgt ctcaaaaagc tgcgcagatc tgatcagcca cacctatttt 799741 cacacgtacg ggcttccggt ctgcattacg cgctgcggaa acttatacgg cggcggagat 799801 ttgaacttca accgcatcat tcctcagacg attcagcttg tgctgaacgg ggaagcgccg 799861 gaaatccgaa gcgacggcac atttgtacgg gactacttct atattgaaga cgccgttcag 799921 gcttatctgc ttcttgcaga aaaaatggaa gaaaacaatc ttgccggaga ggcctttaac 799981 ttcagcaatg agatccagct gaccgtactt gaactggtag agaaaatatt aaagaaaatg 800041 aacagtaatc tgaaacctaa ggtgctgaat cagggaagca atgaaatcaa acatcaatat 800101 ttatccgcgg aaaaagcaag aaagctgctg aattggacac cggcctacac tattgatgag 800161 ggacttgaaa aaacgattga gtggtatacg gaattcttca aaaagtaatg tgaaacgagg 800221 tgaacaagac tgtgaccagc gcgtattgca ccgttttatc aaaaggaaga ttatatcagg 800281 cagtcgcttt gtttaagtcg ttagagcaag ttgatcaaga cagtcccatt tttatacttt 800341 gcatggatga agatacgcac cgcgtgttac agaagctgaa gatgaagcag ctgaaccttg 800401 tgccggtggc cgctcttgaa aatgaattgc tgctgaagct gaaggaaact agagatcaaa 800461 gtgagtattg ctggacgatg aagccgatct ttctgcaagc tgtgctgaac agcaatcctg 800521 agctggagcg tgtgacgtat attgacgggg atctcttttt ctatgcagat ccatcgccga 800581 tttttgaaaa ccagccggac tgctcggtgt tgctttcacg aggggatatt gtaatccctt 800641 cttttgagaa agagcagatt gacatgctgc agcgtctttt aggcagatat aattccgggt 800701 ttatcagctt caagcatgat gatgcaggca cggattgctt ggagtggtgg aaggaacgct 800761 gtcttgagga atgcaaaaat gcaccgggtg aagggaaatt cggtgatcag ggctatttgg 800821 attatatgtc tgagctgttt ccgaatgtgt gtgacattac aacacccggc gtgaacatcg 800881 gccattggaa ttatggacag catacgtttt cctggaaaga tggccggatc gtgctggagg 800941 atggcagtcc gctgatcttt tatcatttca gcggataccg aatcgtcagc atcaatgaaa 801001 tcaaacagat tcatgaaaca acccgcacag atctgccgtt tgtgcatgaa ctgtatcaag 801061 agacactgcc gcatatcatt cagcacatgc aaacgttaga ccctgaattt aacggttttg 801121 cttcaaaaga tgacaacaaa taaatgagta aatacaggaa gtgaaaatga agtgaaagca 801181 agcgttatta ttcctgcata taattcgaag gagcgtcttt acaacagcct tctgtcatta 801241 aaccagcagg agtgcgatga agaatttgaa gtcattgtag cggacaatgg ctctgaggac 801301 gggacgctct cgatgcttga gtcatttcaa gctgattttc cgctgatctt tacacggatt 801361 aaagaaaaca ggggcattgc gtacggacga aatcaggcgc ttcgcaatgc cagaggagac 801421 atcctgattt tccatgacag cgatatgctt gcggcaaagg accttgtggc aaaacatatt 801481 aaagcccatg agaacgaaga gaatctcgtc gtgtgcgggt tgttttggaa acggatctac 801541 agtttttact atgaacgatt tgaagaagaa cataaggaac agctcgcaaa gctcacaggt 801601 gaaatgccga agaaagacaa acaaaagctg ctggaggaag cggacatcaa aaacggaagc 801661 tttcttgata aaagctttga cctcgatacc gactttatag acgtgctcaa gaagatttta 801721 gatgagtacg gcgatgactt gaaaggctat catatgccat ggcgcttttt tatcacgaat 801781 aattcctctg tgaaacgcaa gcatgtggtt gacctcggtt tatttgacga aggcattgtg 801841 cggtacgggt ttgaggatta tgacctcggg atcaggcttc atcaggccgg attgaccttc 801901 aggcttcgcc gtgatattgt cagtgttcat caggaacatc caagcaattg taagtctgta 801961 gacgatattc gggcaaacat tgcctatatg tgcgataaat acaataacat ccgctcctta 802021 gacgttcatc tcgcttttaa tgggccgttc ccgcctgaca tgacgaacag aatcatggct 802081 gatattcaaa agctgctgga atcacagaaa tatgatatgc tgctgaatct gtttcttgag 802141 cttctgcatg ttgttaaaga gcgcaacatt gatccggatt ggcgaaagaa atccccaagg 802201 gtgacggcga aaagctttga tttgcaaact gtccgcaagc ttctgcctaa ggcgaagaaa 802261 aagctaggcg tgaacgattt tgccaacgca ctgtatgcgc ttgtcaacga tttgctgcac 802321 gtggatctta gatcattgga tgtggtataa gtgagtacat ttcatttttc aacgatagtg 802381 tcaaggacac atatctttaa gctcatgcct atgattcatt ctctccatga gcattgcgat 802441 gattttcatt tatatgtgct gtgtgtcgac cagaaagcgt atgaattgct tcagcacgtt 802501 ccatgggagc atgtaacctt tgtgcagctg catgaaatgg aagacccgga gctgttgaaa 802561 gcgaaaagca acagaacgtt tcatgaatat tgctggacgt taaagcccgc ctttttgttt 802621 catgtgatga gcaagtggga tgacgctgaa tactttgccc atatggatac ggatctattt 802681 ttcttttctg atccggcacg tatttttgca gaaaacccaa cggcgtctct gtatttgact 802741 gatcatcgta attcgccgcg cttcatgtcc tactacgacc gaaccggacg ctttaataca 802801 ggctttgtcg gcgccggtaa tacaaaggaa gcatatgaag cggtgtggca gtggagacag 802861 gactgtattg aattttgcac ggtcgaaatg gatacggaac gaaagacata tggtgatcaa 802921 agatatgtgg agaaatggcc ggagcagttt aaaggtgttc atgttgtcaa atccatagga 802981 gccaatacag cgctttggaa tatcgaaaac tataaggtcg ggcaaaagga cggccgcgtg 803041 tatatagatg aaacgccgct gattttctat catttctctg ggtttacgct ggtgacagaa 803101 aaagagttta atctttgctg gtactaccgg attgaagacg aagcgacaat taagatgatt 803161 tatatgccct atatattaaa tctgaaaaga tggattgatg aaatacagtc ggcgtttccg 803221 gactttgcgg atggctttat cccgaagcac gcagtgcctg acactcattt tatccagctg 803281 gattaaaaaa ccccctgccg cctggcaggg gttttttcag ctatgccatt ctctcagctt 803341 ctggtcactt ggcaatagga aggcaaggat gccgaggaca gggagaaagg caatggcgat 803401 catcgtcggg gtcagtcccg cggcatcaat cagagcgccc agcgccacag cgccgattgc 803461 gcccatcccg aaggcaagcc cgacggttaa accggacatt gtgccgattt ttccaggaac 803521 tagctcctgt gcgtagacga ccgttacaga aaagctcgac atcagaacca agccaatcaa 803581 tgcgagcacg ccgtaggcga gaaccgggcc ggcaaatggc agcacaatcg ccagcggcgc 803641 cgagcataac agcgaaccga ggataacgaa gcgttttcca aaacggtctg caagcgggcc 803701 gccgagaaac gtgccgatcg cgccgaacag caagaagaca aaaatatagc tttgtgcctg 803761 ctgaatgctt acgtgatagg tatccatcgc gtaaaacgtg taaaagttac cgatcgcact 803821 cgtataccaa gaacgagcaa aaatgagaaa tataataata ataagagcag atacaacaga 803881 tttggtgatg gccgtgtttt cagccgtttt cttttgcttg cctgatttct gggcaaggct 803941 gccgagacgt gaggcgtacc atttcgcaat atacatgaga aacataacag caagcgcggc 804001 gacaagcgtg aaccaaacag cgccgaattg cccgagcggc acaaggatca gcgcggtgat 804061 cagcggtgcc atcgcctggc ctgagtttcc gcccacctga taaatcgatt gggcgagccc 804121 gcgttttgtg ccggcggcca tatacgccac acgggagccc tccggatgga aaatggccga 804181 gcctaatcca atgaaaaaca cacagcataa gatcgttatg aatgacgggg caaatgcaag 804241 gcccaaaatg ccaagcatgc tggcggtcaa accgactggc agcgcatacg gccgcggccg 804301 tttatcggta taccagccga caacaggctg catgacggat gacaccatgt ttaatgtgaa 804361 agcaatgatg ccgagctgtg taaacgtcag gctcatggag cgttccaaaa tagggaacat 804421 ggccggaatc acagcctgaa gcgaatcgtt gagcatatgg caaattccga taataatcaa 804481 aatcggatac accgtggtgc ctggtttttg aactgttttt tcttttaacg gggcggcgat 804541 agccattgag tctcctcctt acatatataa ccaaagcata ccaccatatt attcataagg 804601 tgaagaattt atcaagagga aaaaagattc ttatgaaaga aataccgtca gcctgattag 804661 cagctgacgg tattttcgat attcaaaatg tgatatagct cttcaagctt acgaatctca 804721 taggttggta tgatctctgg cacattcggc ttcatgtcag ggttcatcca gcaagtatca 804781 agcccggcga gctgtccgcc tttgatatca gcagttagtg aatccccgat gattaatgtg 804841 tgctctgctg aaaattgagg aatccgttca aacacgtaat tgaaatattc cttcatcggc 804901 ttttggaagc cggtgtcttc agaaacgaaa atgtccttga agaatggaaa taatcctgaa 804961 tcacggagac gcttatattg tgtgtgagac acgccgtttg tcacgatgta caaatcaaac 805021 tgttgctgca gatttgagat gagatcaaat gcaccgtcaa taagctgatg tccttcttca 805081 agaaagcggc ggtatttttg ctcaagcaaa gcgccgtccg cttcgtaacc gtactccttg 805141 agcaaagcgg aaaaacgtgt gtttacgact tcatcccgtg tcatcttacc ttcttcaaag 805201 gctctccaga gaccttgatt gatggtttta tactgcgcct tcatgtcatt tgttaaagga 805261 atgttctgat cttcaaacag caaacgcagg gctaaagctt ctgccgcttg aaaatcaagg 805321 atggtatcat ctacatcaaa taataaagtg cggtatcgct tcatctgtgt gtctcccttt 805381 ctcatatgta ttcaaagtat agcacataaa aaaaggaaaa agccggcggg tgaggcaccg 805441 ccggctgaaa agagattatt tgtttaataa gctgtgtttt ctcgaatata ggaagtaaac 805501 cagcgttccg acagcgatcc agatgacaaa tgaaagccat gtgacgccgg gaaggctgta 805561 catgaaccaa aggcagatgc ctgcgctgat aatcggcaca accggaacga atggcactct 805621 gaaggacgct ttgatttcag gatgtttctt tcttaacaca atgacagcaa tggaaatgac 805681 cgtaaacgcg gcaagtgttc ccatgttcac cagatgggcc agcgttccga ggttaataaa 805741 gccggcgatt cccgctgcaa cgatccctgt cagccatgtg ttgcggaacg gggttttaaa 805801 tgacggatga acctttgcga acaatccagg cagaaggccg tctctgctca tggcaaatgt 805861 caagcggacc tgtgcgtaca gcaaagcgag catcaccgtc gtaatcccga taatcgcacc 805921 gacagaaata attccggcaa cagcgtcctg tccgacgaat ttcagcgcaa aggatacagg 805981 atctccgaca ttcaatttgg cataaggcat catgcctgtc agcacaagcg ataccgcgat 806041 gtacagaacc gtacagacgg ctagagctga aataatgccg acgggcatgt ttttttgcgg 806101 atttttcact tcctctgatg cgttagaaac cgcgtcaaac ccaaggtacg cgaagaatac 806161 agtggcagcg ctaagtatga cgcctttcat cccgaatggc ataaaaggag accagttatc 806221 cggtttcaca tagccgatgc cgacaataat gaacaataat atgatcgcga ttttcatcag 806281 tacgatgacg ttgttaaagc gtgtgctttc cttgacgcct ctgctgacaa tcgcagtgat 806341 gaggagaatg atcaccgcag ccggaaggtt aaatacggcg cccgccatgc ttcccggcgc 806401 tcctgtcagt gcagccggaa tatgaagatt gaagccggca agcagtgatt gaaagtatga 806461 agaccagccg gtggcaaccg ccgacagtgc aatgacatat tcaagcatga gatcccatcc 806521 gatcaaaaag gcgagcagct ctccaagtgt cacgtatgag tatgagtaca cgcttcccga 806581 aatcggaatg gaagacgaaa actcagcata acagaaagca gccagcgcac aggcgagccc 806641 cgctaaaata aacgatatga tgagggcggg acctgcaccg gtcgctgcca ctgttcctgt 806701 aatgacaaaa atccctgtac cgatgacaca accgataccg agcaaggtta aatcaaatgc 806761 gcttaacgta cgggcaaggc tttttgactt gctctgcgca ctcaatgttt caagcggttt 806821 ttttctaaat aatgaactca tcaaaagttc ctcctagaaa tattcaaaat attctaatca 806881 ttatatgcag ttcttgttgt attatattgt cgaaatttga cgtagtcaat aaaatatttt 806941 tctgctttaa atgatagaag cgaaacagcg ttgtcgtatc ataggatagt aatttttact 807001 aatcgtatat tcaattttat gcaagatgaa ccgatagaaa aaatagattc gcccatattt 807061 tgatttgcgg ttataaagga gatgctgacc atgtttcaat atgaagagtt gaataaacag 807121 tttatcggcg ggaaatggca ggagggcagc agcccaaatg tattggaaaa caaaaatcct 807181 tatactcaaa aaacattcac aacattccgt aaagcgactg ctgacgatgt agatgaagcg 807241 tatcgggcag cggcgctggc aaagaaaaaa tgggatgcgg tcaacccgtt cgagaaaaga 807301 accattttag aaaaagccgt cacgtatatt gaagaaaatg aagaagccat tatttatttg 807361 attatggagg agctaggcgg tacaaggctc aaagcagctt ttgaaatcgg tcttgtcaaa 807421 aacatcataa aagaagcggc aacgttccca atccgcatgg aggggaaaat tcttccgtca 807481 acaatagatg gcaaggaaaa cagattatat cgcgtgccgg caggcgttgt cggtgtcatc 807541 agtccgttta acttcccatt ctttttatct atgaaatcag tggcgcctgc actcggagcc 807601 ggcaatggcg ttgtgctaaa gccgcatgag gaaacgccga tttgcggcgg aacgctgatt 807661 gcgaaaattt ttgagaacgc gggaattcca gcggggctgc tgaatgttgt tgtcacagac 807721 attgctgaaa tcggcgacag cttcgttgag catccagtgc cgcggatcat ctcatttacc 807781 ggttctacga aagtcggcag ctacatcgga cagcttgcga tgaagcattt taaaaagccg 807841 cttcttgagc ttggcgggaa cagcgccttc atcgtacttg aggatgcaga tatagaatat 807901 gcggtcaatg cggcggtgtt cagccgattt acacatcaag ggcagatttg catgtcagcc 807961 aaccgcgtgc ttgttcattc ttctatttat gacaagttcc ttgagctgta ccaggcaaaa 808021 gtggaatcgc tgaaagtcgg cgacccaatg gaccctgata cgattatcgg gccattaatc 808081 aacagcagac agacggacgg gctgatgaag actgtagagc aagcaattga agaaggcgct 808141 gtaccagtga agcttggcgg atttaacggg acgatcgtgg aaccgacgat cttaaaagac 808201 gtcaaaccgt tcatgagcat tgccaaggaa gagctgttcg gaccagtcgt ctcctttatg 808261 aagtttgatt cagaagacga agcggtggat atcgcaaacg aaaccccgtt tggcttgagc 808321 ggtgccgtac atacgtcaaa tcttgagcgc ggcgtggctt ttgcgaaacg cattgaaaca 808381 ggcatgattc acgtcaatga cacgaccatc aatgatgaac cgaatgtagc cttcggcggt 808441 gaaaagcaat caggcctcgg ccgtttaaac ggtgagtgga gcctcgaaga atttacaacg 808501 ctgaaatgga tctcggtcca gcacgaaaaa cgcagcttcc cttattaatg aaaaggagtg 808561 aatggaattg accataaata cggaaaaaga aaccgcagat attctggacg catttatcaa 808621 agtagcccct tatttaaaca gcctggttca ggatgatatt acaatcggca tttatgatac 808681 ggaaaaactg ctcgtgaata taccggccaa aaccttttcg ctgaacgtaa aagccggcga 808741 tccgctgcag gaaggggata tcatcacaga tgccatccgc agcaatcaga agaagacgag 808801 catggttccg aaagaattgt tcggcttccc attgatcgcg cgtgccatcc cgctgcacga 808861 cgagaatgga agagtcattg gaggcgtcgg cctcggaacg agccttgagg agtcgtcaaa 808921 gctgcatgat gtcgcggaaa gcttatcagc tgttgttgaa caaacagccg cggctatttc 808981 cgacatttct gaatcaatta acgggttttc aactcaaatg tcgggcattt cctctcaggc 809041 gaaaaaagta agcgaaagcg ccggtgaaat cgccgatatt tcagtaactg ttaaaggcat 809101 ctcggaccaa agcaatctgc tcggcttgaa cgccgcgatc gaagcggcaa gagcagggga 809161 gtccggaaaa ggattctctg tcgtcgcaga tgagatcaga aagctagcga cgcattcaaa 809221 agaaaatgtc ggccaaattg accagattac gaaaaaaatc cacagcctgc tgaaagggct 809281 ggaggaatcc attgagtcga ttaaccagca tacagacgga caagccgctg ctgttgaaca 809341 aatttccgcc acgatgcagg agatttcagg aagcgcgcag catcttgcga aaatggccga 809401 aaaagcgctt gaggaagagt aagagaccgg ggacaaacat ccccggtctt tttcttatcc 809461 tgcatttcca tgaaattcgt ctgacgtttt actagtttta ttccagcggc tgatttaaaa 809521 tgtacacatg aacttacgtg aggattgata ggaaccatga gcatattaaa agcggaaaat 809581 ctttataaaa catacggaga taaaacatta tttgaccata tctcctttca tattgaagag 809641 aatgagagaa tcggattaat cgggccgaac ggaacaggaa aatcaacgct gttgaaagtg 809701 attgccggct tggaatctat cgaagaagga gaaatcacga aatccggaag cgtgcaggtc 809761 gaatttcttc atcaagaccc ggagctgcct gcggggcaaa cagtgctgga gcatatctat 809821 tccggtgaat cggctgtgat gaaaaccttg cgtgaatatg aaaaagcgct gtatgaactg 809881 gggaaagatc ccgaaaatga acagcgccag aaacacctgc tggcagcaca agcgaaaatg 809941 gacgcgaaca atgcatggga tgcaaacacc ttggcaaaaa ccgtattgtc taagctgggc 810001 gtcaacgacg taacaaaacc ggtcaatgag ctctcaggcg gccagaaaaa acgggtggcc 810061 attgccaaaa acttaattca gcccgctgat ttgctcattt tggacgagcc gacaaaccat 810121 ttggataatg aaacgattga gtggcttgaa gggtatttaa gccaatatcc cggcgccgtc 810181 atgctggtga cgcacgatag atatttctta aaccgtgtca ccaaccgcat ttatgagctt 810241 gaaagaggca gcctctacac ttacaaaggc aactatgaag tgtttttaga aaaacgcgcg 810301 gaacgggaag cgcaggctga gcaaaaggaa acgaagcggc aaaacctgct gcgccgcgaa 810361 ctggcttggc tcagacgagg agcgaaagcc cgctccacaa aacaaaaagc gagaattgac 810421 cgggtagaga cgcttaaaga gcagacaggc cctcagtcat caggttcact cgattttgcc 810481 attggctcgc accgtctcgg aaaacaggtt attgaagcgg agaacgtcat gatcgcttat 810541 gacggccgca tgctcgtcga ccgttttaat gaacttgtca taccaggtga acggatcggg 810601 atcatcgggc cgaacggcat cgggaaaaca acgctgttaa atgcccttgc cggccgtcat 810661 acgccggacg gaggcgatat tacgatcgga cagacggtca gaatcggcta ctatactcag 810721 gatcatagtg aaatgaacgg tgagttaaaa gtcattgact atataaaaga aacggcggag 810781 gtcgtaaaaa cggcagatgg cgatatgatt acagctgaac aaatgctcga gcgtttcctc 810841 ttcccgcgtt cgatgcagca gacgtatatc cgcaagctgt ccggcgggga aaaacgccgt 810901 ttatacttgc ttcaggttct catgcaggag ccgaatgtcc tgtttctcga tgagccgacg 810961 aacgatttgg atactgaaac attaagcgtt cttgaggatt atattgacca gttcccaggc 811021 gtcgtcatca ccgtatccca tgaccgctat ttccttgacc gcgtcgtcga ccgtttgatt 811081 gtatttgaag gaaatggtgt catttcccgc tttcaaggct cctatagcga ctatatggag 811141 gagtcaaaag cgaaaaaagc ggccccaaaa ccggcagctg aggaaaaaac ggctgaagcc 811201 gagccgaaga aaaaacggaa aaagctttct tacaaagacc agttggaatg ggacggcatc 811261 gaagataaaa ttgcccagct ggaagaaaag catgaacagc ttgaagctga catcgccgca 811321 gcaggcagtg attttggcaa aatccaagag ctgatggccg agcaggcgaa aacggcggaa 811381 gagcttgagg ctgcgatgga ccgctggaca gaattgtccc tcatgatcga agaactggaa 811441 agctaaaaag cgtggccgca gcaggccgcg ctttttttca cataatggac aaaaacgaac 811501 cggcctgctt atgttaggat aaagttgtgt gtcagcggca catggaaaac taacggagat 811561 gatgaagtat gacatgggcg atcgtgatgt taattctcat gagtctggtg aaaatcgtat 811621 taacctgtct tcctacaggc gtcatagaat ggctgctcgg caaatttgaa gtgcacgcca 811681 agctgagtga cgaaaatgcg agtctctctc tagatggaaa acgcctcgag ggtgcagaga 811741 agcagaaagt gattgatcaa tttaacgaag ctatcttcct ggaaaaatat tatatctatc 811801 caggtgatga agagcgttat ttacatccgg aaaacggcgg cacgcctctg gtgatagata 811861 caaaaaaagg aaaaaaagac gtgaagctgt tcgtgtaccg ctacgacgac catatcgacg 811921 tcgtgaaaca gtacaagaag aaagtgatcg cgtatcgagt gctttctgaa agccttcaaa 811981 aagagtctct gtcagtggcg ggaagtttag cttaaacagg aaagtgaaag acgggtgctg 812041 tatgctgctc gtctttttta ttgtttttta aaacttaacg tttacgttaa ggttcaaaag 812101 gtgtataatg gtaacagaaa cggcgaaggg ggatttacct tggaatggat gaagattgat 812161 caagtggcca aaagaagcgg gctgacaaag cggaccatcc ggttttatga agaaatcggc 812221 ttgattccgg cgccgaaacg gacagacggc ggtgtaaggc tttattcaga ggatgatatg 812281 gaggagcttg agaaagtcat cagcacaaaa gaggtgctcg gtttttccct tcaggagctt 812341 cagcatttca tggaaaccag ccgccagcta gagttaaaca aagaggggta tttgttgtca 812401 ctggatccta aggaacggaa agaaaaactg gaggaaattc aggaaaccct gaatcaccag 812461 ctggatttga ttgatgagaa aatccgcaca ttccaaagct ttaaagaacg cctgcagggc 812521 atgaaaggca aagcggaacg cgccattcaa tcaatcgaat gaaaagtttg ttaaacgcta 812581 tttttgtagc gtttctttta atggaataaa gatggaggtt aggtcaaatg gataagacaa 812641 cacaagtgaa tcagaaaacg ggtttgctca gccagccaaa agcggtatgg gctgtcgcgt 812701 ttgcctgtgt gatttctttt atgggaatcg ggctggtcga tccaattctt ccggccattg 812761 ccgcacaatt gcatgcttca cctagtgaag tatcactctt gtttacaagt tatttgcttg 812821 taaccggatt tatgatgttt ttctcaggag ccatttccag ccgcatcggc gcgaaatgga 812881 cattaattct cggacttatt tttattattg tgtttgcggg gcttggcggc agctcaagct 812941 caatcgctca gttagtcggc tatcgcggcg gctggggatt agggaatgct ttgtttattt 813001 caacagcgct tgcggtcatc gttggcgtgt cagtcggcgg cagcgcccaa gcgattattt 813061 tgtatgaggc cgcgctcggt ctcgggattt ctgtcgggcc gcttgcaggc ggagagctcg 813121 gaagcatttc atggcgcgca ccgttttttg gagtatctgt cctgatgttt attgcgttaa 813181 tcgcgatttc tttcatgctt ccgaagctgc cgaaaccggc gaaacgcgtc ggtgtgtttg 813241 atgcgatgaa ggcactcaaa tataaaggcc tgctgacaat ggcggtatcg gcattcctat 813301 acaactttgg attttttatt ttgctagctt attctccgtt cgtactggat ttagatgaac 813361 acggtcttgg atatgtcttc ttcggctggg gccttctgct ggcgattacg tcagtcttta 813421 cggcgccgct cgtgcacaaa gcgctgggca cagtgcgttc gctagtcgtt ctctttatcg 813481 cctttgcggc cattctcgtt attatgggga tctggacaga ccatcagact ttgattatta 813541 catgtatcgt tgtcgctggt gctgtcctcg gtatggtgaa tacgatcatg acaaccgctg 813601 tgatgggttc tgcgccggtt gaacgttcaa tcgcgtcttc agcctacagc tcagtccgct 813661 tcatcggcgg cgcgctcgcc ccgtggattg caggaatgct gtcagaacac tttactgcaa 813721 gcacaccata tacagtaggc ggaatcgtcg tttttgtcgg catgcttgtc cttctcatgg 813781 gacgtaaaca tcttgctgga attaaggcgg ggcattaata acgaaagaca ctgcgcatat 813841 gcagtgtctt tttattcgtt ataatgcatc ataatcgaat tggtgcagga aaggacaacc 813901 tttatgacac aattttacta ttttccggct gaaaactccc tttagaaacc ggttttttcg 813961 gtcagcaaga acggcgttcg cggaaagggc atccgcttcg gtcaggcatt gatgcggctg 814021 ggatttatct tgcagaagct gagaatgtgt ccgttcattt acgattgcca tttcagtgat 814081 ggttcatgct gtagagggga cgtttgccat ggataaggca aaacctgacg aatatgatca 814141 gaaatgttta gaaacgctct atcaatacat acacagcgtc atgaaaaaca gcttttctcg 814201 gtcgagtggt ttaccgcttg ggaagatgag gaggattttg agctgtctgc caaaagagag 814261 ctgacacttg atgaattcac atctccattg cagctcattt taaaagacag agagcttttg 814321 agaatcgttc agaaaaaatg gcagtaaaaa acccgccctt tagcaggcgg gtttttttat 814381 aaattaaagc actttcgtcg tccaagactc gcagttccac gtttctgtcg caatatccat 814441 ataaaagtct ggctcgtggg aaatgagcag aatggagcct ttatattctt tcagggcgcg 814501 cttgagctct tccttggcat cggcatccaa gtggtttgtc ggctcatcga gcaccagcag 814561 gtttgtttct gagttgatta gcttgcacaa tctgactttc gctttttcgc ctccgcttaa 814621 tacggagacg cggctttcga tatgctttgt cgtcagcccg cattttgcca gagcggcacg 814681 gatttcatac tgcgtataag aagggaattc gctccatact tcttcgatgc acgtattgtt 814741 gtttgtttcc ttgacctctt gctcgaaata gccggtatag atgtgctcac cgcgttcaac 814801 agagccttcg agcggctgga tttcaccaag caaacttttc agcaatgtcg tttttccgat 814861 cccattcgcg ccgtaaaggg cgattttttg gccgcgctcc atgcggaggt tgagcggacg 814921 ggacagcggg gaatcgtaac cgatcacgag atccttcgtt tcaaaaatca gcttgcctga 814981 cgttctcgcc ggcttaaagt ggaattccgg ctttggcttt tctgccgcaa gctcgatcat 815041 atccatctta tcgagtttct tttggcggga catcgccatg tttctcgtgc tgacacgcgc 815101 tttgttgcgg gcgacgaaat ccttcagctc cgcgacttcc tgctgctgct ttttgtaggc 815161 cgcttcaagc tgctgttttt tcacctcgta gacttccata aactgatggt agtcgccgac 815221 ataacgtgtc agctcttgat tttcaacgtg ataaatcagg ttgatgacac tattcaagaa 815281 cggaatatcg tgggaaatca ggatgaacgc gttctcgtat tcctgcaggt agcgtttcag 815341 ccattcaata tgctgttcat caagatagtt ggtcggctca tcgagaagca gaatttccgg 815401 cttttcaagg agaagcttag cgagaaggac ctttgtgcgc tgtccgccgc tcaaatcggt 815461 gacatctcgc tctaaaccga tatcgctcaa accgagaccg cgggcgattt cttccacctt 815521 ggaatcaatg acataaaaat cattgtttgt cagcgcgtct tgaatgacgc cgacttcttc 815581 aagcagcttc tcgagctcgt cgggatcagc ctcgcccatt ttgttgtaaa tctcgttcat 815641 ttcctcttcc atcgcaaata aataatggaa tgcgtctttc aggacgtcgc gaatggattt 815701 tcctttttcc agcacggtat gctgatcaag gtatccgaca cggacatttt ttgaccattc 815761 gacttttccc tcatcaggtt caagctttcc ggtaataata ttcatgaagg ttgattttcc 815821 ttcaccgttt gcgccgatca agccgacgtg ctcgcctttt aacaggcgga aggaaacgtt 815881 attaaaaatg gcccggtccc cgaaaccgtg gcttaaatcc tttacagata aaatactcat 815941 gtttacacct ctatcgttat caaacacgca caatcggcgt gtaatattca cccttttgat 816001 tataaaggag gattcggaat gttgaaaggt ataggaaaga aaaagaaaaa ttgcgttccg 816061 ggcgaggttt tgagatacta tggaatagat ttcaggaatt gaggagaaca aaatgacgca 816121 aacttggcca tttttacata atgcacaatc atttatacaa gagaattgga atgcttccgg 816181 ctttcaaaag ccaacccctg ttcaggagca ggcagcccag ctgatcatgg acggaaagga 816241 tgtcattgca gaatcgccga caggcacagg gaagacgctg gcgtatgcgc tgccggtctt 816301 ggagcggatc aaaccagagc aaaagcatcc gcaggcggtg attttagcgc cttcccgtga 816361 gctggtcatg cagatttttc aggtgattca ggattggaaa gcgggctcag agctgcgcgc 816421 ggcttcctta atcggcgggg cgaatgtgaa gaaacaggtc gaaaagctga agaaacatcc 816481 gcatatcatc gtcggcacgc caggcagggt gtttgaactg attaaagcga agaaactcaa 816541 aatgcatgaa gtgaaaacga tcgtgcttga tgaaacggat cagctcgtcc tgccggagca 816601 tcgcgaaacg atgaagcaaa tcattaaaac aacattaaga gaccgccagc ttctatgttt 816661 ttctgccacg ctcaaaaagg aaacagagga cgtgctccgc gaattggcgc aagagcctga 816721 ggtgttgaag gtgcagcgaa gcaaggcgga ggcagggaaa gtgaagcatc aatacctgat 816781 ttgcgaccag cgcgacaaag tgaagctgct gcaaaagctg tcaaggcttg aaggcatgca 816841 ggcactcgta tttgtgagag acattggcaa cctgagtgta tatgcggaaa aactggcata 816901 tcaccacgtt gaactcggcg ttttgcacag tgaagcgaaa aaaatggagc gagcgaaaat 816961 cattgccaca ttcgaagacg gagagtttcc tcttttattg gcgactgaca ttgccgcacg 817021 cggtttagat attgaaaacc tgccatacgt gattcatgct gatattccag atgaagatgg 817081 ctatgtccac agatcaggac gaacaggccg ggccggaaaa gaaggcaacg tgctgagcct 817141 tgtgacaaaa ttggaggaat ctaagctgaa aaaaatggcg aagaagcttg gtgttgagct 817201 gagtgaagct gtgtatgcag gcggaaaact gaagacgaaa taaaaagaag ggcgaagagc 817261 cctttttttg ttgtaaaata atagaaaaga ttttgcgcgg aggtgggaaa atggcttcaa 817321 tagacaggtt tcaagtaatg caggagccag agctgaaaat ccttgaacac tggtttgaga 817381 atgaggatac cagacggaga atggatggga tgctgctatt agatgagtgg tatgcacgag 817441 taaataaaga taaacacgat actgtcatca tggcgtatga tggacagctg ccggcaggga 817501 tggtcgttat tgagttcgga gaggagcgga catatattgg attgatcgtc aatcctttgt 817561 accggcttaa agggtatgga aaacagatac tgcaaaagct gatgaccgaa cctgatttta 817621 ctagcgtgcg agaatgggtg gcatgcattg aagaagacaa tcgaatcagt ttagcttgct 817681 ttcaagcagc aggattcact ttagaagaca cggaacctga tgaagatggt tttcttacgc 817741 tgattcttcg caactgatct catcgaaaca caaaaggagg gcaaaaagcc ctcccgtttt 817801 catcttcatt cagctcggat cactgacctt gatcagctgt ttccctttat tttctccctt 817861 aaataaaccg agaaacgcgt caggaatgtt ttcgaagcct tctgtgatgg tttcctcgta 817921 atggagttta ccagccttca gccattctgc cagctgtttt gctccctcag aaaaacgatc 817981 ggagtagtcg cttacgataa agccttgcat cagcgacttc gttttaatga gttttgattg 818041 gacacgaggg cccatgtcat ctgcttcgct ttctgcgtta taggaagaaa tggcgccgca 818101 caccggaatg cgggcaaatt cattgagcag attcatcacc gcgtctgaaa tcggtccgcc 818161 gacattgtca aaatacacat cgacaccgtc aggacaagcg ttttgaagcg ctttttggat 818221 atcatccgct gttttgtaat tgatggcttc gtcaaactga agctcctgtt ttaaatagtc 818281 gattttttca tcagagcccg cgatgccgac gactcgcgcg cctttgattt tggcaatttg 818341 cccgactgtt gaaccgacgg ctccggcagc tcctgagaca accacggttt cgccttcctt 818401 cgggcgtccg atgtccagca atccgaagta tgctgttaag ccggtcattc ccaaaatgcc 818461 gagataggcc gaagcgggag caaggcttgt atcaattttt cgcaaggcag actcgctcac 818521 agcggaaaat tcctgccagc tgagatttcc gatgacgata tcgccttttt tcagatgatt 818581 cccgtctgac acaacttcag cgataacccc tccagaaagc gctttatcca aggcgaacgg 818641 ctcaacatat gacttcgtat cctgcatacg gccgcgcata taagggtcaa ccgatacata 818701 aagcgttttg acaagcactt ccccttgctt gggttcagga accggaatgg tttcaaagcg 818761 aaagtcttca tgaacaggaa taccttgtgg acgtcttgct aattgaattt gctgctgaga 818821 tgctgtcatt ttcatcctcc tatcacttgg ttgacaccac tgtaacatgg acaggagagg 818881 aaatacaaaa ggtaagctgg catacaaaaa aggttataga tgagcttatg ctttctacaa 818941 gctcttttgt tttaaaagtt ctctttagtc atttatcatt attagaaaac agaacagaaa 819001 aagagctcct gtacacctag ctaagattgg ctagtgtgta tgtcgattct ttttcatatt 819061 cttgcaagca tctgcgaggg ggagcttagt cgttcacatt ttgctttcgc atcaatctgc 819121 aatagcaaag tctatgcgat ttttttacat cagcaaagat ttgttcaatt ttttcctttt 819181 atgccgagtt tttctgaaac agataattga tggtactcaa ccattttctt ttggtcaata 819241 aagtaatgtt tacttattaa ttaaacacgc gaaaaagcaa acgaaaacat aattaaattt 819301 tatatattta ttaaaagctt atatgtttat ttaccttttt tttgaattgt aattgagaaa 819361 atccatatat tgcggacact aataaaagaa tacctgctga aacataaact aaacgaactc 819421 caaggaaatc tgaaatagcc cctatagcca gaattgaaaa cataaaaatg aactgtacta 819481 aagaagacct tgcagacatt atattaattc gagtttgctc ggttgttatg ttctgaataa 819541 gtgtttcttg tgtaagatct cttaatatat aagccggccc cataaagaga accaaaatta 819601 gagctaagta tgaattactt ataaaaccat atattaaagt taaacttcca tatgagacag 819661 cgccaattaa cataaaatta attaacttat tttgaaatct ctccgacagc ttatatatta 819721 taaatccccc tatcatcgaa cctaaataat atgctccatt aataaatccc caccatgatt 819781 ctcctttatg caagacttcg ttaacgaaag ctaaagagac agatcctatc caaatcattc 819841 ctgcccatga ctcaattaaa tccataataa taattgttct aagtttcttt tggctaaata 819901 aataccgcca accacttact atactcttat tgggagaatt tttttcacgt atgacagaat 819961 tagcgtggcc atgtggtaga caaaataaaa gagaaagaag agatgtaaac aacaaaaaga 820021 tagtaagtat aatggtatat ccctcaccta aaaatgcaat tatgagacca cctaaagacc 820081 agcctacaaa ttgaaaagtt tggtccactg tagataataa tccatttgct tttactcttc 820141 tatcaggaga gattatttcc cctataattg cactttttaa aggtgagaac catccattaa 820201 aaaaggaaat acagctaata ataataaaga ctaaaatgag agtttgatta gagtaagttc 820261 ttaataaagc atagaacaaa catattaata acagcatttg tatcaattga gaaataatta 820321 ttgtaagagg cagttttaat cgaattgtta ttaacggtaa tatagcactt ccaaaaatac 820381 gaaaaataat acttattaat gtcaccatag aggcgatggt tgtcgaattg gtcattttaa 820441 acaaaaacga aatcactacc atagtatata gagaaaaacc taaatttgta gtggtctggc 820501 taaataaaat agaataataa cctttactca tatgtatcct cccttggaat aatttttctc 820561 ggtaaagagc ttaaacatat ttaaacacct taaaacaaca aaagtaaaga aaaaatttcc 820621 ttgtaaacta tttactttta ttctatttat tgttattgtt tatttaagtt ctctgactat 820681 tctatcaata ttcagggaac cacatatctt attaaagggg ggaaaaccat gagaaaatta 820741 agaaaaaact ggagaaaatc gattgttagc ccggttcttt atactaatga aaaatggtaa 820801 acacttaggg aatagcattt aatgctattc cttatttcaa caaacaaatc gggaggttat 820861 cgtaatttga ctctattaat gcaagatcat aaatcaattt acaataaaga tatagaaata 820921 ttaattgaag ttgaagaact tattacttct gttccagaaa ataaaaaaaa tgattttaag 820981 agtttaatcg ataatagaat tatgactcta ctaaataaaa ttcaacaccc tgtagcagcg 821041 gaaaatgtgt ttgggatgtg tattgcttat ccgaatactt acataaggta tagattaatt 821101 gatttcgttg aaaaatgggt accttatttc tctgctgtag aaactataat caatctaacc 821161 caggatccgg atgatttagt ttcttttaaa gctatggatg tctgtgcaaa tcataaaatt 821221 gaagaatctg tagcatattt gtcttcgatt attgatgatg tccgggagag tataagctac 821281 cctaaaaaac ctgtgggatt aggggcccaa aaagtattaa gtacattatt agatatattc 821341 ggtgttgaaa aacatgaaga gctagtaatg ctaaaaaatt attttgatca aaatggtata 821401 cttcctaata actttgactt tgaagaaaaa attcctcaaa gtctaataga ggaattcgaa 821461 aaaacagaag aagatgggat gattttaatt ccgggtggct tttttgaatt cggtttaaat 821521 gaaaatgaaa ttcctgacaa aacatttaat tggaaagatg ctgttcctag acaaaaagta 821581 tggttacctc cattttttat cgataagtat cctgttacaa ataaagatta tgatatcttt 821641 accgagttca tagaggaaaa tgggcatata ttctgtcatc ctaatgaacc gcagaataaa 821701 caacatagaa gaaatacata ttgggatgat aggtatttag ataatcatcc cgttacaggt 821761 atagattttt atgatgcatt tgcttacgca agatataagg ggaaagaatt gccaaccgag 821821 tttcaatggg aaaaagctgc tcgaggcgaa aagggtaatg tctggccttg gggagataaa 821881 tttgatcctg caaaggttca atatgctgga agtctttata atgaacccat tacttcttta 821941 aagtcctgga gagaaaattt attaaaagct catgctgata aagaattaaa tcatttaaca 822001 agtgatattt ttgaacaaaa tggtgaaagt ccctatggag tatgcggtat gatcggcgga 822061 acatgggagt ggactagaag tgagcttaaa acaaagagag ctttccaccc tatttttgag 822121 aatgtaccat ttaatagtgt taactcattt gccgttctta aaggaggatc attcttctct 822181 catccaggct taatgttccc ttcttttaga gcaaaagata ttcctttctg tcgacacaat 822241 gaaatgggga ttagatgcgt aaagaatatt ccagtatata aaattagaga atcaattaat 822301 gggccaatta ctaataaagc aatttattaa tcattctagg ttagagactt gataaaagta 822361 tactaacatt gtgtagtaat gttcagcttg tagaaaaaac aatgtttttt ctacaagatt 822421 ttattttaaa tgcttttcaa aattatcagg gattgagaat cagaaaaaga gccattaagc 822481 tcgatcttag ctaggtatta cgatcttctg tatattattg tgagaaatat agaagattca 822541 gttagttagc atttcgattt taagctgagc ctgcaatagc aaagcatctg ttttgattat 822601 tctttttctg atacataagc taattttgtc gcttttcttt tttgtctttt cacgcatttc 822661 gaggatgact tactataatt ctttcagctt ttctatgtgt taagattcga atagatgaaa 822721 taactttaac aagttggtca ataagaacag atttaacttt atgttaaaag agtatctcgt 822781 atagaacata agaagaatga cgagtttttt aagattatca tcaattatgt gagaataaaa 822841 tattataagg gaaaatgaag gctgtcacgt ttctcgacag ccctagggaa ttcctctcct 822901 tttcatttcg cccgtaattt cgggcacagt cccgtcggca ggcacattgg cttctggtcg 822961 atcgggcttc tcatgatgca gcattccaag ccgaagactt cacggaaaaa tggctgggtg 823021 aacacatctt ccggtgttcc ggcgttgtat atttttccgt ccagcacact gatcagatag 823081 tcagcatatt gagcggcttg gtttaaatca tggagcacca tgacaacggt gcggccatgg 823141 tcgcggttca gctttttcag cagttcaagc acttcaatct gatgtgagat gtctaaatac 823201 gtggtcggct catcaagcaa aagcaaatca gtgccttgcg caagtgccat ggaaatccag 823261 gctctttgtc tttggccgcc tgagagggca tcaagtgtcc gatccttcag ttcaatcatg 823321 cccgttgctt ccagcgccca ctctaccatg tcatgatcct cttgggtatg cttggataac 823381 agctttttgt gaggatgtct gccaaaatag cataattcct ctaccgtcaa tccttcagga 823441 gcctgaggag attgtggaag aatggccagt ttttttgcga cttcttttga tggctggcgg 823501 tggatgtctt ttccttctag tagcactgta ccgctttttg gggccatcag cctggcgagc 823561 gatttgagga ttgttgattt accgcagcca ttagcgccga tgagcgcagt gatttttcct 823621 tcttctatct ttaagtcgac tccgtcaata atcactgtac tgtcatatga aagagtgagc 823681 tggtctgcag ccagttttcc catggtatcc tctccctact gtttcctcgc ttcgaatttc 823741 aataaatata agaaataagg cgcgccgatc acggctgtca gtattccggc aggtatttca 823801 accggaggca tgatgccgcg ccctaacgta tctgcaatta ataatataat agcaccaatc 823861 aatgccgatg caggcagtaa atatttagct ttttctccgg taagccgtct ggcgatatgc 823921 ggagcaagca agccgataaa accgattgag ccgacgacgg ctacacagct tcccgccagc 823981 gccaccgcgg tgaaaatcag gatgaatctc agccggtttg cgttttctcc gagaccctgt 824041 gcaagctcat ccccgagtga cataagatcc agcttcggta tgagtatgca gacgatcgga 824101 aaaagaatca aaagccatgg cgcaagcagc ttgacttctt cccagtttct tccccagagg 824161 cttcctgtca gccaaatgag tgcagcattc acgtcgcctg gaaacttgac catcatatat 824221 tgcattccgg cgtggcagac cgcgcctaaa gcaatgcctg ataaagccag tgaagagggc 824281 tgaatgctct tttttcgggc tatcattaat aatagtacag caataatggc ggctccggca 824341 aatgcggaga acggaagcac gtataccggc gactcaggaa agatgagaat cacagccatc 824401 gccgcaagtc cggagccttt tgaaatgccg acaacgtccg gggaagcgag cggatttcgg 824461 atcacaccct gtaaaatcgc tccggcagcg gcaagtccag cacctgccaa aatcgctaat 824521 ataatgcggg gaaggcgata ttgctggatg ataaattcaa aggaatgatc cagtcccagc 824581 agattcgtca ctaccgcatc aggtgaaatg tataatgcac cgattccaat gctgatgacg 824641 gacagaacga ttaaaatcac ggccaatatg agtatcgcca gtaaggggcg tttttgtttt 824701 ctggttgttt tcttcatttc aggtttcgcc ctttccttgc caaatataag aaaaacggcg 824761 ttccgataat cgcggtgaca atgccgaccg gtgattcata aggaaatgca atccatctgg 824821 ccagaacatc tgcgtacacc agcaaaatgg caccgaacag tgccgaaaac ggaagcacgt 824881 attgataatg ttctccgatc agcttgcgga caatatgcgg gacgagcagc ccgacaaagc 824941 caatcggccc ggcgacggct acggaagcgc cggaaagaat taaaataatc aaactgatca 825001 gaatcctgat gccgttcata ttttgtccaa gcccttttgc tgtttcgtct ccgagaccga 825061 gaacagaaac agaaccggaa aatacgaggg caagcccgat gccaatgaca gaaaaaggag 825121 cgatggttat gacgtcctgc cagttgctgc cgtcgattgc gcctgtcatc cagtacagaa 825181 catcctcacc tgactcattt aaaataatga tggcctgtgt catagaggag aggaacaagt 825241 gcacggccat tcctgacagc gccagcttga caggcgtcat tccgccggat gaggcaatca 825301 tatacacaat cgcgccgcct gctgccgcac ccgcaaaagc gaatataaca gatgaatagg 825361 gcgatgccgg cagaatgacg agagaagcaa caacaaaaag cgatgcaccc gcattcacac 825421 cgaaaatttg gggtgaagcc agaggatttc tggtcatagc ctgcatcagc gcccctgcta 825481 cagctaggct ggcgccgaca aaaacgccga ttaatgtgcg gggaaggcga agagtagaga 825541 tgatgagctg ttcctttgaa ccgtcccata caaaaagata tttcaatgaa tctatgatgc 825601 tgatgtctga ggctcctact gaaagattca gcccaagccc aaatataaaa ataatcagtg 825661 caatgataaa catcatcagt cttgatgatg agcgccgttt ggctgaatga tacaacagtc 825721 tcacttcctt actgcgtctg gttgcaaaaa cgaagaagca aggattcccc tcgcttctca 825781 tttgtcctat ttattataca cttttttaag cacatctttg gcgcttgttt cactagactt 825841 gatgcctctg aatcttgtcc aagtgtcacg gtccgcatca tagacttgtc catttttcac 825901 cgctttgaga tttttccaga gcgggttcgt tttccactca tctacaatgg ttttgccttc 825961 gttggctgag atgaacaaaa tatcaggatc gattttgctc aattgctcaa ggctgacctc 826021 ttgataggcg ttatctgact tcacagcgtg tgtaaagcct agcattttaa agatttctcc 826081 gtcataggat gatgatgtat gaagctggaa ggaatccgct cttgcaacgc cgagaacgat 826141 gttgcggttt tcatctttcg gaagttcggc ttttagatcg ttgatgactt ttttgtgctc 826201 ggcaagcttt tcttttcctt catcttcttt atttaatgct ttagcaatgg tcgtaaagct 826261 gtcgatcgtt tcgtcatatg tcgcttcacg gctttttaat tcaatcgtcg gggcgatttt 826321 tttcagctgt ttataaatgt ttttatggcg ctcagcgtca gcgatgatta aatcaggctt 826381 caaggaactg atgacctcaa gattgggttc gctgcgtgtg cctacagatg tgtaatcaat 826441 ggagctgccg acaagctttt taatcatatc ttttttgttg tcatctgcga tgcccaccgg 826501 cgtaatgccg agattgtgaa cggcatccaa gaatgaaagc tcaagcacaa ccacccgctt 826561 aggtgtgccg cttactgtcg tttttccttc ttcgtcatgg atcactctgg aatccttaga 826621 ctcgcttttg ccgcttccgt tgttattctg gcttgatgaa cagccggata caatgaggca 826681 ggcgagcaat aaaacactca tgatggcaat caacttgtta gaataggtgc gcatgtcatt 826741 cttccttttt tcagatttag taatgagaat cattatcaca tgtaacacta taatagcatg 826801 gcttatcatg tcaatatttt tttagtaaag aaagctgcgt ttttactgct ttctcatgaa 826861 agcatcatca gacacaaata agtggtatgc agcgttaccg tgtcttcgag acaaaaacgc 826921 atgggcgttg gctttagagg tttcgaacat atcagcagtg acataaggaa ggagagtgct 826981 gagataaccg gacaatttct tttctatttc atctgttagt gcaaattcaa tgtcgccgat 827041 attcatgata atcgagaaaa caaagtcgat atcgatatga aaatgttcct cggcaaaaac 827101 cgcaagctcg tgaattcctg gtgaacatcc ggcacgctta tggaaaatct gtttgactaa 827161 atcactcaca atccaagcat tgtattgctg ttctggtgaa aagtattgca ttagacatac 827221 ctcctgctcg tacggataaa ggcagcgttt catggtcgtg tgctccgtgc agcggcttct 827281 ccttaatttt gatttttctg aaaataggtc ccgttcctat cactttacca tggacggaaa 827341 acaaatagct actaccattc ctcctgtttt tctcttcaat gttctggaat ctgtttcagg 827401 tacagacgat cgggtatgaa agaaatatag aaaacatgaa ggaggaatat cgacatgaaa 827461 ccagttgtaa aagagtatac aaatgacgaa cagctcatga aagatgtaga ggaattgcag 827521 aaaatgggtg ttgcgaaaga ggatgtatac gtcttagctc acgacgatga cagaacggaa 827581 cgcctggctg acaacacgaa cgccaacacg atcggagcca aagaaacagg tttcaagcac 827641 gcggtgggaa atatcttcaa taaaaaagga gacgagctcc gcaataaaat tcacgaaatc 827701 ggtttttctg aagatgaagc cgctcaattt gaaaaacgct tagatgaagg aaaagtgctt 827761 ctctttgtga cagataacga aaaagtgaaa gcttgggcat aaagcaagga aaaaaccaaa 827821 aggccaatgt cggccttttg gtttttttgc ggtctttgcg gtgggatttt gcagaatgcc 827881 gcaataggat agcggaacat tttcggttct gaatgtccct caatttgcta ttatattttt 827941 gtgataaatt ggaataaaat ctcacaaaat agaaaatggg ggtacatagt ggatgaaaaa 828001 agtgatgtta gctacggctt tgtttttagg attgactcca gctggcgcga acgcagctga 828061 tttaggccac cagacgttgg gatccaatga tggctggggc gcgtactcga ccggcacgac 828121 aggcggatca aaagcatcct cctcaaatgt gtataccgtc agcaacagaa accagcttgt 828181 ctcggcatta gggaaggaaa cgaacacaac gccaaaaatc atttatatca agggaacgat 828241 tgacatgaac gtggatgaca atctgaagcc gcttggccta aatgactata aagatccgga 828301 gtatgatttg gacaaatatt tgaaagccta tgatcctagc acatggggca aaaaagagcc 828361 gtcgggaaca caagaagaag cgagagcacg ctctcagaaa aaccaaaaag cacgggtcat 828421 ggtggatatc cctgcaaaca cgacgatcgt cggttcaggg actaacgcta aagtcgtggg 828481 aggaaacttc caaatcaaga gtgataacgt cattattcgc aacattgaat tccaggatgc 828541 ctatgactat tttccgcaat gggatccgac tgacggaagc tcagggaact ggaactcaca 828601 atacgacaac atcacgataa acggcggcac acacatctgg attgatcact gtacatttaa 828661 tgacggttcg cgtccggaca gcacatcacc gaaatattat ggaagaaaat atcagcacca 828721 tgacggccaa acggatgctt ccaacggtgc taactatatc acgatgtcct acaactatta 828781 tcacgatcat gataaaagct ccattttcgg atcaagtgac agcaaaacct ccgatgacgg 828841 caaattaaaa attacgctgc atcataaccg ctataaaaat attgtccagc gcgcgccgag 828901 agtccgcttc gggcaagtgc acgtatacaa caactattat gaaggaagca caagctcttc 828961 aagttatcct tttagctatg catggggaat cggaaagtca tctaaaatct atgcccaaaa 829021 caatgtcatt gacgtaccgg gactgtcagc tgctaaaacg atcagcgtat tcagcggggg 829081 aacggcttta tatgactccg gcacgttgct gaacggcaca cagatcaacg catcggctgc 829141 aaacgggctg agctcttctg tcggctggac gccgtctctg catggatcga ttgatgcttc 829201 tgctaatgtg aaatcaaatg ttataaatca agcgggtgcg ggtaaattaa attaagaaag 829261 tgaaaaacac aaagggtgct aacctttgtg ttttttaatt aattaaaatg tttattaact 829321 tagttaagga gtagaatgga aaaggggatc ggaaaacaag tatataggag gagacctatt 829381 tatggcttca gaaaaagacg caggaaaaca gtcagcagta aagcttgttc cattgcttat 829441 tactgtcgct gtgggactaa tcatctggtt tattcccgct ccgtccggac ttgaacctaa 829501 agcttggcat ttgtttgcga tttttgtcgc aacaattatc ggctttatct ccaagccctt 829561 gccaatgggt gcaattgcaa tttttgcatt ggcggttact gcactaactg gaacactatc 829621 aattgaggat acattaagcg gattcgggaa taagaccatt tggcttatcg ttatcgcatt 829681 ctttatttcc cggggattta tcaaaaccgg tctcggtgcg agaatttcgt atgtattcgt 829741 tcagaaattc ggaaaaaaaa cccttggact ttcttattca ctgctattca gtgatttaat 829801 actttcacct gctattccaa gtaatacggc gcgtgcagga ggcattatat ttcctattat 829861 cagatcatta tccgaaacat tcggatcaag cccggcaaat ggaacagaga gaaaaatcgg 829921 tgcattctta ttaaaaaccg gttttcaggg gaatctgatc acatctgcta tgttcctgac 829981 agcgatggcg gcgaacccgc tgattgccaa gctggcccat gatgtcgcag gggtggactt 830041 aacatggaca agctgggcaa ttgccgcgat tgtaccggga cttgtaagct taatcatcac 830101 gccgcttgtg atttacaaac tgtatccgcc ggaaatcaaa gaaacaccgg atgcggcgaa 830161 aatcgcaaca gaaaaactga aagaaatggg accgttcaaa aaatcggagc tttccatggt 830221 tatcgtgttt cttttggtgc ttgtgctgtg gatttttggc ggcagcttca acatcgacgc 830281 taccacaacc gcattgatcg gtttggccgt tctcttatta tcacaagttc tgacttggga 830341 tgatatcaag aaagaacagg gcgcttggga tacgctcact tggtttgcgg cgcttgtcat 830401 gctcgccaac ttcttgaatg aattaggcat ggtgtcttgg ttcagtaatg ccatgaaatc 830461 atccgtatca gggttctctt ggattgtggc attcatcatt ttaattgttg tgtattatta 830521 ctctcactat ttctttgcaa gtgcgacagc ccacatcagt gcgatgtatt cagcattttt 830581 ggctgtcgtc gtggcagcgg gcgcaccgcc gcttttagca gcgctgagcc tcgcgttcat 830641 cagcaacctg ttcgggtcaa cgactcacta cggttctgga gcggctccgg tcttcttcgg 830701 agcaggctac atcccgcaag gcaaatggtg gtccatcgga tttatcctgt cgattgttca 830761 tatcatcgta tggcttgtga tcggcggatt atggtggaaa gtactaggaa tatggtagaa 830821 agaaaaaggc agacgcggtc tgcctttttt tattttcact ccttcgtaag aaaatggatt 830881 ttgaaaaatg agaaaattcc ctgtgaaaaa tggtatgatc taggtagaaa ggacggctgg 830941 tgctgtggtg aaaaagcggt tccatttttc cctgcaaaca aaaataatgg ggctgattgc 831001 ggctctgctg gtctttgtca ttggtgtgct gaccattacg ttagccgttc agcatacaca 831061 gggagaacgg agacaggcag agcagctggc ggttcaaacg gcgagaacca tttcctatat 831121 gccgccggtt aaagagctca ttgagagaaa agacggacat gcggctcaga cgcaagaggt 831181 cattgaacaa atgaaagaac agactggtgc gtttgccatt tatgttttga acgaaaaagg 831241 agacattcgc agcgcctctg gaaaaagcgg attaaagaaa ctggagcgca gcagagaaat 831301 tttgtttggc ggttcgcatg tttctgaaac aaaagcggat ggacgaagag tgatcagagg 831361 gagcgcgccg attataaaag aacagaaggg atacagccaa gtgatcggca gcgtgtctgt 831421 tgattttctg caaacggaga cagagcaaag catcaaaaag catttgagaa atttgagtgt 831481 gattgctgtg cttgtactgc tgctcggatt tattggcgcc gccgtgctgg cgaaaagcat 831541 cagaaaggat acgctcgggc ttgaaccgca tgagatcgcg gctctatatc gtgagaggaa 831601 cgcaatgctt ttcgcgattc gagaagggat tattgccacc aatcgtgaag gcgtcgtcac 831661 catgatgaac gtatcggcgg ccgagatgct gaagctgccc gagcctgtga tccatcttcc 831721 tatagatgac gtcatgccgg gagcagggct gatgtctgtg cttgaaaaag gagaaatgct 831781 gccgaaccag gaagtaagcg tcaacgatca agtgtttatt atcaatacga aagtgatgaa 831841 tcaaggcggg caggcgtatg ggattgtcgt cagcttcagg gagaaaacag agctgaagaa 831901 gctgatcgac acattgacag aggttcgcaa atattcagag gatctcaggg cgcagactca 831961 tgaattttca aataagcttt atgcgatttt agggctgctt gagcttgggg agtatgatga 832021 agccattgat ctgattaaag aggaatatgc gatacaaaat gaacagcatg atcttttatt 832081 ccataacatc cattcgcagc aggtgcaggc cattttgtta gggaaaataa gcaaggcatc 832141 ggaaaagaag gtcaagctgg tgattgatga gaacagctca ctcgcgcctc ttcctgcgca 832201 tatcggcttg tcccatctta ttacgattat tggcaattta attgataacg ctttcgaagc 832261 tgtagcggag caaagcgtga aggaagtttt gttttttatc acggatatgg gccatgacat 832321 tgtcattgaa gtatcagaca cagggcccgg tgtgccgcca gagaaaatag aagctgtgtt 832381 tgagagaggc tattcttcaa aggggatgag gagaggctac ggtctggcca atgtgaaaga 832441 ctcagtgcgt gaactgggcg gctggatcga actggcgaat caaaaaactg gcggggcggt 832501 attcactgta tttataccga aggagaaaca aagggggaat ccatttgatt cacatcgcga 832561 ttgcggagga tgattttcga gttgcgcaaa tccatgagag attgattaaa cagcttgatg 832621 gattcaagat tatcggcaag gcggctaacg caaaagagac attggcgctt ttgaaggaac 832681 acaaggctga tttgcttctg ctggatattt atatgccgga cgagcttggg accgcgttga 832741 ttcctgatat acgaagccga tttcctgaag tggacattat gattatcaca gcggcaacag 832801 aaacccgtca tttgcaggaa gcgctaaggg cgggaattgc ccactatttg atcaaacccg 832861 taacagctga caagttcagg caggtgctgc ttcagtataa agaaaaaagg aagctgctca 832921 tgtctcagcc ggaggtcagc caatccatga tcgaccatat ttttgggaac ggtgtgaaga 832981 cagctttgcc ggcagaggat ttgccgactg gcattaattc gattacactg cgaaaaatta 833041 aggaagcgct tcagactgcg tcagaaggat tgacagcgga ggaacttggg gaaaaaatgg 833101 gggcgtcacg aacaactgcc cgccgttatg ccgagtacct tgtgtcaaag gaagaagcaa 833161 gagccgagct tgaatacggg attatcggca ggccggagag aaaatattat ttggcggcgg 833221 attagatatg aaaaaatcta taatcctatt gaatattcta ttgatcttta tgcagggtga 833281 tatcaggcag gcggctgcgc cgcgcctgcc ggacgggccg atagaaattg tcgtccctgc 833341 cgaaccttct ggcggctggg atgtcacagc gcaggcgatc caatcagttt tgaggcagaa 833401 gcagatcgtg aaggatgatg ttcatatcgt ctataaatcc ggcggcgggg gagagaaagg 833461 ctggaaatat gtcaacaaaa gcagcaaaca aaccatcagc atgacgtcca gcctaatatt 833521 gagcaatgat cttctcgggc aaagcaaatt aaaaatgtcc gattttacgc cgctcgccat 833581 tctctccaag gaatggcaga cggttgcatt gccaaaagga tcagcgttaa caaatggcaa 833641 ggatgtgctg aatgagatca acatgcatcc cggcaaggtg agaatcggct ttgccccggg 833701 gtttggcaat gatgatcagc tctcgttcgt cagagcggca gatatgtacg gcattgaccc 833761 gtttgacatt caattctcac agtatgacag cagcgaacag ctcattcagg cgctgatcag 833821 acatgagata gaagcggctt ccatgacact ttctgaagcg aaaccatatg aacgaaacgg 833881 cgatatcacg ttagccgctg taacgtctga taaaagactt cccggttttc caaatgtacc 833941 gacgtggaag gagcagggaa tcccgtttgt tttttctcat tggagaggga ttttgggccc 834001 gaaaaatatg tctgaggaag agatttctta ctgggatcaa gcgctaaaga aggtcacctc 834061 ctcacctgaa tggaagcgga aaataaacga acaggactgg gaaagctttt atttaaacag 834121 cagggaaacg aaacggtttt tagaagagca atctgctttt tatcaaagca tcatgacagg 834181 aaattaaaat cccgacatcc cgggattttt ttcatgccga aaattgatca aaaagaacaa 834241 aacggtttta aaaaattaaa aatacaaaaa aaccaaatta tttacttgcg gttggttttc 834301 ccatacgatg gcaaaaaggc aagacaaaaa ggggagtaag ggagaaaaaa atgtaagcgg 834361 attcatttaa gggggaatgg atgtgttagc aatcttaggc tttctcatga tgcttgtgtt 834421 tatggcattg atcatgacaa aacggctttc tgttttaaca gcattagttt tgacgccgat 834481 tgtgtttgcg cttatcgccg gatttggatt tactgaagtt ggggacatga tgatttcggg 834541 gattcagcaa gtcgcgccga ctgcggtcat gattatgttt gcgatcttat attttggaat 834601 tatgattgat acaggcctgt ttgatccaat ggttggcaaa attttaagca tggtcaaagg 834661 agacccttta aaaattgttg tcgggacagc ggttcttaca atgctcgtcg ccttggacgg 834721 agatggctcg acaacgtaca tgattacgac aagcgccatg cttccgctct atttgctgct 834781 aggcatccgg ccaattatct tggcaggaat cgcgggagtc ggcatgggaa tcatgaacac 834841 gattccatgg ggaggtgcga cgccgagggc ggcgagtgcg ctgggggttg atccagctga 834901 gcttacaggg ccgatgattc ctgtcattgc aagcgggatg ctttgtatgg tggcagttgc 834961 gtatgtgctt ggaaaagcgg aacgaaagcg ccttggtgtg attgaactga aacagccagc 835021 caatgccaat gaaccggctg ctgcggttga agatgagtgg aagcggccga agctttggtg 835081 gttcaattta ttgttaacgc tttctttaat aggatgttta gtatcgggta aagtcagttt 835141 aaccgtactg tttgtcattg cgttttgtat tgcgctgatt gtgaattatc ccaatctcga 835201 gcatcagaga cagcgcatcg cggcgcattc cagcaacgtg ctggctatcg gttcaatgat 835261 ttttgctgcg ggggtgttca cggggatttt gacaggcacg aaaatggttg atgaaatggc 835321 gatctcgctc gtgtccatga taccggaaca aatgggcgga ttgatcccgg cgattgttgc 835381 cttaacaagc ggcattttca catttttgat gccgaatgac gcgtatttct acggggtgct 835441 gccgatttta tcagaaacag ctgtcgcata cggtgtggat aaagtggaaa ttgccagagc 835501 ctctattatc ggccagccga ttcatatgct gagtccgctt gtgccatcca ctcatttgct 835561 tgtcggactc gtcggagttt ctattgatga ccatcaaaaa ttcgcattga aatgggcggt 835621 tctcgcagtg atcgtcatga cggctatcgc tctattgatc ggtgcgatct ctatttccgt 835681 atgataattc aggcgtaatg acacacacta acggcataca acattccgga ggtgtcatta 835741 tgagtgatcc ttatatgccg ctgacttcag tcagaagcgg agcggggttc gaagcggcaa 835801 aaggggtgca cggcctgact gtgcaaattg cgaatgtcta ttttattcag ctgccttctg 835861 aacctcactc atttgtttta attgatgccg gcatgcccca atcagccggc gtgattgtca 835921 atgaagccaa acaaagattc ggtgaagggt ttcagctgaa ggcgattatc ctcacacacg 835981 ggcactttga ccatattggg gcaatcgaag agatccttga gcattgggat gtgcctgttt 836041 atatccattc tcgggaaatg ccttatgtaa caggtaaaga ggattatcct ccggctcgtc 836101 ctgacagcaa gagcgggctg gtcgctaagc tgtcgccgct gtttccgcgg cactctatcg 836161 atatttcctc acatgtccag gcactgccgg aagacggttc agttcctttt cttgacgagt 836221 ggatgtggat cgcgacacca ggacacacgc cgggccatat ttcgttattc cgcgatgacg 836281 gccgcgtgct tgtggcaggt gatgctgtta ttacagtgga acaggagaaa atggctgacg 836341 tcttgataca aaaacaggag cttcacgggc cgccggctta tttcacgcct gacacagaga 836401 cggccgctga gtccattcta aagctggccg gtcttgaacc ggaagcgtta ttgaccgggc 836461 acggcatacc gatgaccggc aaaaactttc gaagtgactt aactgaattg gcaaatcggt 836521 tatcgtctat ttgacacccg caccacgcgg gtgtttttta ttgttttcca ggaagttgca 836581 gaaaaatcat ttgtcttgcc gcttaaaaac gatacaatga aaagcatgaa gtgatgtgaa 836641 ggggagagtt tgttggaaga aaaagaaata ctctggaacg aagcgaaagc gtttattgcc 836701 gcatgctatc aggaattggg aaaggaggag gaagtgaaag accgtctcgc ggacattaaa 836761 agtgaaattg acctgaccgg aagctatgta catacgaagg aagagctgga gcacggagcg 836821 aaaatggctt ggagaaacag caaccgctgc atcggcagat tgttctggaa ttcgctgaat 836881 gttatcgaca gacgagacgt ccggacgaag gaggaagtgc gtgatgccct ctttcaccat 836941 attgaaaccg ccaccaataa cgggaaaatc agaccgacca ttacgatttt ccctccggaa 837001 gagaagggtg aaaagcaagt cgagatctgg aatcatcagc tgatccggta cgctggatat 837061 gagtcagacg gagaaagaat cggcgacccg gcttcctgtt ccctgacagc agcctgcgaa 837121 gagctcggct ggcgcggaga gcgaacggat tttgacctgc tgccgctcat ttttcgcatg 837181 aaaggggacg agcagcctgt ctggtatgag ctgccgcgtt cacttgtgat tgaggttcca 837241 atcacacatc cggacatcga ggcgttttct gatttggagc tgaagtggta cggcgtgcct 837301 attatttctg atatgaagct tgaggtcggg ggcattcatt ataatgccgc gccatttaac 837361 ggctggtata tgggcacgga gatcggagcg agaaacctcg cagatgaaaa gcggtacgac 837421 aagctcaaaa aagtagcgtc cgtgatcggc atcgccgctg attacaatac ggatttatgg 837481 aaggatcaag cgctagttga attgaataaa gctgtgctgc actcgtataa aaagcagggt 837541 gtcagcatcg ttgaccatca tacagcggca agccagttta aacggtttga agaacaggag 837601 gaagaagcgg gcagaaagct gacgggggac tggacgtggc tgattccgcc aatttcaccc 837661 gctgccactc atatcttcca ccgctcctat gataactcaa tcgttaagcc gaactatttt 837721 tatcaagata agccttatga gtaaacaata gaaaatcgat gatggccttc aaggctgcgg 837781 gattcagtca cagagatgtc ggtaaccttt gagaaagggc ttccgttctt tacagcctca 837841 acaaacgatt gcagggcgtt ttccggaccc tctgccaaaa tctcgacacg cccgtcatca 837901 cggtttttga cccagccggc cagttttcgc ttatcagctt ccatttgaac aaaatagcga 837961 aagcccacac cttgaacccg gccgtctaca atgattcggt attgaagcat gtaaaaacca 838021 ccttttcttt ttatgataat caatcatttt acaacctgta aaggggatgt gtttgtatga 838081 aacaagagcg ctattcagtt ctttctctta atctgggaaa accgcagacg cttgaatatg 838141 acggaaagaa aatcgaaacc ggcatcatga agcggccggc taaatcagcc gtcatgctgt 838201 atcgggagaa ttttgaagga gacggacagg cggacctcgt caaccacggc ggacctgata 838261 aggctgtctg tgtctacccg gcggagcatt atccgttttg ggaagagttc ctctcaagac 838321 cgctgtcaaa tgccgcattt ggagaaaatc tgacggtcgc gggcctgact gaggagaatg 838381 tttgcatcgg ggatgtgttc agacttgatg aagctgttgt tcaggtcagc cagccgcgcc 838441 agccgtgtgt aaagctggcg aaaaagtttg gtgtaaaaga aatggtgctg aaggtccagc 838501 aaaccggcta tacagggttt tattttcgcg tgctggagga gggcagggtg tctcccggcg 838561 cgaaccttga attgctgtcc agaggagaga aaggcatatc cgtccagttc gcgaaccgca 838621 tcaactacca tgatgcaaaa aatctcaccg ccattgaacg gattttaagt gaggctgcac 838681 tatcggaaag ctggagagcg tcctttatga aaaaaaagga caggctgctg ccggttgaat 838741 agaaaaaagc cgcgcatatc aacgtgcgcg gctttgccat atttaagatt gttttttctt 838801 tgattcaagc aggttggcaa gaaaataggt tttatagctt tgaagctttc ttccttcatg 838861 gtgcgtgatc ccctgctttt ttagttctgc cacataccag cctttactgc cgtaatgcat 838921 gtcagaaaac tcctttccct atctgatttc gaaacgattg gcattgtaac atctataaaa 838981 agatgctgaa aagagatgcg gggaaaactg agcctttcgc actagatgta cgaatgttct 839041 tctgaatgta tatgcggagc aaaagccgaa tatgatttaa tggccggtta gtttgatcat 839101 gacaacgcca aatgtcataa tggcgaaaac aatgccgata tatgtgagca tcccgttttt 839161 tttcttaacg ccgtaaacgg tcataatgat gccttcaatg aaaaaaatga tgccgaaaat 839221 aataaaccac atgcagataa aggctccttt cacagacata atagtagtgt agcatatctg 839281 aaagagccgg gctgtgacaa tatcaagaaa gccgggcgca tatcgcccgg ctcatgtttt 839341 attgtttatc aaccaatttg accagaagct gtgccaaatg ttctttctca tcttcgtctg 839401 caacgctcca aagctcttgc agcagcattt cttcaccgtt ttgcggctct tcatgctttg 839461 cgaggtagtc tcccaggatc gcagcgcttt ttacaagctt gccgtcatcc aatcccagct 839521 ttttgcctcg gttgacttgt tttttcaggt agcctttaaa ttcctcaaag tcttttaaaa 839581 tgtcttcttt tattgtgcca tgcatcgcgt tcatttcgtt ttcaatttgg attttttctt 839641 gatctctgtt cattgcaaga cctcctcgta cagaataatg atgctttacc tgcaattgga 839701 ggaggttaaa cctgccggaa gcccggaatg tgttttacag tttcgtcagg ataatcggtt 839761 catcttttgt gatgacgatc gtgtgttcaa cttgggcaac catgctttta tccggcgtct 839821 tgaacgtcca gccgtctcca gcttcaacaa tcgtttctgc tttcgttgaa ataaacggtt 839881 caagcgcgat gactgtgcca tttttgaaca gcgcattatc aaacggatca taatagttca 839941 tgatgtggtt cggcgcttca tgcaggcttc ggccgattcc gtggccggtc agggttttga 840001 tgacggtaaa gccttgagag cgtgcttcat gataaacggc tcttccgatc tggttttggc 840061 gcttgcccgc ttttgcctgc tgaagcccct tttgaaaagc gttttccgcg cattggcaaa 840121 gcttatgaag gcgttcttct ccttcaccga gcacaaatga gatgcctgtg tcggaataga 840181 agccgccaaa ttcagcggag atgtcgatgt tgacaaggtc ccctgctttt aaaattttgg 840241 atgtgcttgg tatgccgtga gccacttcat catttacgct gatacatgtc acacctggaa 840301 aatcgtattc cttctcagga gctgaaacgg cgccgtgctc atcaagcaca gcttttccga 840361 taaggtcaag gtcttttgtg ctcatgccgg gctctgcctt ccgcttcatt tcttcacgcg 840421 caagcgcgac gattcttccg atttttttca ggccttctaa ttcttgatcg tttgttacaa 840481 tcatctgtca ttcccgcttt ctttttaaat aatctagatt aagcttacca caactgtctt 840541 aaaaatagga aacacacgga cctgggaaaa aagaaatacc cccgggaaaa ttggtataga 840601 tcactagata tcttatatgg tatatttgaa aaaaaagggt atgaggggga tgggtatgct 840661 ttcattttta caaaaactcg ggaagtcatt tatgctcccg attgcggttc tgcctgcggt 840721 tggaattatc cttgcgcttg gcagagagga tgtatttaat atcccgtttg tctatcaggc 840781 ggggacggcg gtttttgatc atctgccgct tatttttgcg atcggtattg ccatcggcat 840841 ttcaaaagac agcaatgggg cagcgggttt atcaggggcg atatcgtatc tgatgcttga 840901 cgcggcaaca aagacaattg ataaaacaaa taacatggcg gtgtttgggg gaattattgc 840961 cggtttaatt gccggttaca cctataaccg cttcaaggat accaagctgc ctgaatatct 841021 cgggttcttc agtggcagac ggcttgtgcc gattttaaca gccattatta cgatcatttt 841081 agcgggcata ttcggagtgg tctggccgcc gattcaatcg tgtatcaact cgtttggaga 841141 gtggatgctc gggctcggcg gcatcggggc aggcatattc ggcctattca acaggctgtt 841201 aattccgctt ggccttcacc atgtgctgaa caatattttc tggttccaat tcggagaata 841261 taacggagtg acaggggatt tggcgcgctt tttcgcgaaa gatccgactg cgggcacata 841321 tatgaccgga tttttcccaa tcatgatgtt cggtcttccg gcggcgtgtc tggctatggt 841381 tgtgactgcg aagccgtcta aacggaaagc gacggctgga atgatgattg gatttgcttt 841441 aacggcgttt atcacaggga ttacggagcc gattgagttt gcatttatgt ttttatctcc 841501 gcttttatac gctgttcacg cggtcttaac cgggttatct ttatttatcg tcaactggct 841561 cggcatccgc tcaggcttct ctttttcagc cggagctatc gattatgtgc tcagctatgg 841621 aatcgcggaa aaaccgctgc ttctgctttt ggtaggtata tgctatgcgg cagtatactt 841681 tatcgtgttt tatgtactga ttaaggcttt gaatttaaaa acgcctggac gggaagacga 841741 tgatgtggat gaagtgctgg atgaaaatac tgttcaggat gtaaatgaaa acatcatgct 841801 gaaagggctc ggcggaaaag aaaaccttca aaccattgat cattgcgcca caaggctgcg 841861 actgactgtg aaggataccg ctttggtgga tgaagcactg ctaaagaaag caggcgcaaa 841921 aggggttgtc aaatcgggcg ggcaatcggt tcaagtcatt attggcccga atgtggaatt 841981 tgcagctgag gaattgaggg ctgctgtcaa ataaaaaagc ggagagggca acctctccgc 842041 tttttcttat ttatcttcgt tatcctttga cgtttcggaa gaatcttcgt catgttttgt 842101 gtaatcataa tcagaaggat tcaccttctt aaaacctttc ggctcgtaga accgcagcag 842161 gtctccgttt atgattttat cggacatttc aagttccttc ttgacgagtg agtcttctga 842221 cttgtcgact tcggattcat cgagttcttt tccggttttc gtgtcgtaat acttaccgga 842281 tattttcgtg tacttcggtg aaataaagtc tccgtttcgg aacggaatca cttcacggtg 842341 ttctttcgat aaaatatcag aaccggacat cagatagtcc ttcgtatcca ctccgagcag 842401 atgcagaatg gtaggagcca catcaacgtc tccggcatat ttatgaactt tctcgccctt 842461 cacgccggca gcgtggataa agagcggcac ccgttgaagc tgggcgttgt cgtaatcagt 842521 gatttcatcc ttgccaagca ctttcgccat cgctttattg tggttttcag agatgccgta 842581 gtggtctccg tacatcacaa taatcgattt atcatataac ccgtcttttt tcagatcatt 842641 gaagaattgt tcaatggact gatcaaggta atgggctgac tggaaatagt tatcgacgac 842701 agagtcacca aagtctccag ccgggaagtc tgtatccccc tcatccattc cgaatgggaa 842761 gtggttggaa agggtaatga acttcgtata gaacggctgc ggcaggcttt ccagcagcgg 842821 cattgattct ttgaagaacg gtttgtcttt catgccgtag tttttcgtgt tttcttcgtt 842881 catgtcatag taagcagaat caaagaattt atcaatgcct tccgccttgt acatttcgtt 842941 acggttccag aacgtctgcg tgttcccgtg gaaagtagca gatgtgtaat tcttagactt 843001 cagaatcgcc ggaacggatt gcagcgtgtt ttgcgctttg tttacgaaaa ctgaaccttg 843061 agccagcggg tacagagagt tttccatcat aaattcagca tcagatgttt taccttgtcc 843121 cgtttggtgg aaaaagttat caaagtagaa cgtttcgtta tcatgtgcca gtttatttaa 843181 gaatggtgtc acttctttgc cgtcaatttt atagtcgatg ataaatgact gcaaagattc 843241 aagtgaaacg taaatgacgt tttttccttc cgctttgccg aaatacacgt tattcggcac 843301 atcgtaattg gctttcatgt agttttctac ttccgttacg tcgctggaat cggcaagcgc 843361 gcgctggctg ttggacttga tattctgtac agcgtcataa atcgtgaaat tgtatgttcc 843421 caagtatttc acaagatagt tccggtcgaa tgatcttgtc agcaattcag gacggtctga 843481 ttccgcaact gccaggttga tcaagaacac aagaattgaa gacgcaaaaa taattcggaa 843541 cgattttttg cttgacgttt cggcaggctt gtttactttg atcgccaaga tgatcaggat 843601 gatcgtatcg ataaagtaaa aggcgtcagt cggtctcatc agcgaaaatg cgctgtcacc 843661 gagttggccg ccgtttgttt tagcctgcat aatgaccgga attgtaataa aatcattgaa 843721 aaatctgtag tacacaatgt tggcgtacag taaaaaagac attaaaaaat gaatcactat 843781 aatggctgtc tgctgtaatt ttttcttgaa caagagtcca aagccaagaa agaacaagct 843841 tgagctaaga ggattcacaa aaagcaatat tttttgtatc gtgttgtcta ttcctaagtt 843901 gaaattcagg acataaccga catacgtttt gatccataac aggacgaccg caattaagaa 843961 gaaggccagt cctctttctt ttataaatgt tttcattgtt acactccttt tttccgatcc 844021 agttcgagcg aaacgataga aaaaacgaac gtatccaata taacacgaat cagcagatta 844081 gaaaagtgaa aatcgtatga gggagaaagt ggcgaaaaac gccgtcgaat caacgtttcg 844141 ctttgatatt accaaatgta aaacaaggta tctttctaga aataaaggaa taaaatggta 844201 cattgagaat tgtatgataa aatataaggt atagataaaa agaggtgaaa tgatggattt 844261 ttcccatatt gtgtctgaag ataaaattaa gcgcgccatc aaagacgggg actttcaaaa 844321 cctcccggga atggggaagc cgctgccgaa ggatgacgcg gcacacttgc cggaatcgct 844381 gcgcatgggc tatcgtattt tgaaaaacgc gggaatggca gaggacgagg gcgcgctcaa 844441 aaaagagctt atgaccatcg accatttaat cgaaaagtgc tatgacgaaa aagaacgcga 844501 gcaattaatc agaaaaaaat ctgaaaagca attgctgctt gataagcttg tcgacaaaaa 844561 aggcatgttt tcaaagccag catccgcttt ttataagaat aaagtatatg accggcttgg 844621 acgaaacaga ccttcttcca gctgatttgt cttgtctgca ggatggcgat tgataaaagc 844681 catccttttt atgttccaag ttctatgtca aaaggtttat gtttttccat ctatgggaaa 844741 tgattcataa acgaaaaaag ggtgatggga tggaacgact attagtatgg atagagcata 844801 tatctgattg gctgtggggt ccgccgctaa tcatcctgct gacggggacg ggcttgtatt 844861 tcactatttt gctgaaaggt tttcaatttc gctatccttt atacattttc aaacagacaa 844921 tcggcagtgt aggaaaaaag ccgaagggag aaggcacagt cacaccgctt caggcattga 844981 cctcagccct cagttcaacg atcggtgcag cgaacattgt cggtgtgccc gccgctatta 845041 tgtttggggg accaggagcg gttttttgga tgtggcttat tgccttattt gccatggcga 845101 ttaagttttc tgaaagtgtt cttgctgttc attacagaga aaaaaatgag cagggtgaat 845161 acgtcggggg accgatgtat tacataacaa aagggctgcg catgaaatgg ctcggcgtat 845221 tcttctctgt tgcgctgatt gtggagctga ttcccagcat tatggttcag ggaaattcgg 845281 tttcagtctc gcttgccgag acgttttctt tcaataaaat atacgcagga atcggaattg 845341 catttttgat tgggttagtg gtgataggag gggtaaagcg gatcggaaaa gtaacagagt 845401 ttgtcgtgcc tcttatggca ggggcatacg caggtgccgg tctcctgatt gttctcatga 845461 atctatcatc agtgccggcg tttttctctc tcgttttttc aaatgcgttt acctcttctt 845521 cagcagttgg agggttcgca ggtgctgcgt tggcggaaac cgttcgctgg ggatttgccc 845581 gcgggctgta ttctaatgaa gccgggatgg gaacagcccc gattgcacat gcggcagcaa 845641 tgactgatca tcctgtgcgg caagggtttt ggtctgtgat cggcattgtc attgacacct 845701 taatcatctg tacgactacc gcttttatcg tccttgcatc cggtgtatgg acagggaaga 845761 acgcctcaaa tgacccggca gcactgacaa cggccgcatt tcagcactat ttcggttctg 845821 gaggaggata cttcgtttcg gtttccctgg tcttctttgt cgtatcaacc attatggttg 845881 tcatttttta cggcgtaaag caagctgaat ttctgttcgg gcggctggca ggacatgtga 845941 ttaaattcgt ttatttagcg gctattatca taggtgccgc aggcggagca aaagccattt 846001 ggggcgtatt ggacttagca ttggttttta ttgttgtccc gaatgtgatt gcgctcttgt 846061 tattgagcag aaaggtaaaa gcgctgtaca ccgaattctt tacatctgaa cagtactacc 846121 tgaaagatat aagaaaaacg aaacaaaagc ctgtttatcc aacaaaagaa gctaaaaatt 846181 cctagtgttt tgcttttgcg ccgaacaatg ctttgctttt tatgatcaaa taaatgagta 846241 aaggcagcaa aagagaaatc actacattaa tgattggttt gattctgtta aagtcgatta 846301 gctgatttgt atttaaaaaa aaccaaaagc cgcatacgac tgagaacatg ccggttggtg 846361 tatacatggc tttcgggtcg atttttgagt gtaaaaacga aaggccgtat accacgatat 846421 atagggaacc tgctatcttc accataatga ccggaatcca aaaagccgcg atgatcaggt 846481 ctgagcgatc cagaaaatcc gtaatgcgga tctgcctgat gaccatataa gcaggatcaa 846541 agaaagtaga tgtcaggttg ggaccaaaga cagaaattga agaaaataac atcacggcca 846601 gcaataaagc gcccagcagt atcgcgaaaa tggtgtattt tagcgggacg ctccggtttg 846661 agaagagaag cggaaggata atcaattccc ccattgtccc aaacgcgtaa tagcctgatt 846721 gaaggtatgg gattagacct tcaaaaacag gtgtcaagtt ttgaagctca atttgtgtgg 846781 ccagcgtaaa tggaaggaac aagaccagga tgccgaatgg aaataggaat atctgcgcca 846841 ttctggtcaa tgtttctttt ccctctctgg caatacagat cgccacaaag ataataacac 846901 cgccaagaac agccattggt gttctcggga gaaataaaat gttaatcaaa ttgatgaaaa 846961 aacgtatatc atgagcattg attaacagga aatacaaaga aaacagtaaa atgataatcc 847021 ggcctgcgat tggtgaggaa tcgctcagca gctcatagat atttttatcc tgatgctttt 847081 tcatcagcct atgcatgagc cagagtgccg gaatcacgat gacaacgccg aggatgtagc 847141 tgtgccaggc attttgtttt gctgattcga tcatgagaat cggagcatgc tttaatccga 847201 ctgctaacgt atacagagct ccgaaaaata atccttggta tgcagaggtc ttgtccataa 847261 agcacatcct ttctgtcatg ttcaaaacgg aatatattta aacaggtgcc ccagccgcgg 847321 aagcagggga ttcactctca tataaatcca tagaaaagca cttcctgcaa ttagcaggct 847381 gaaggcccat tttgttagat tgttagcgga acgaaaattc ttccattcat atgcgtatat 847441 ggcaatgcac acaatcaatg tctgtacgat atagctgatc atgctgacgc acctccatta 847501 atggctgatc gttttgtata ggacaccgcc ctgctcaatc gtcacaattg ggacgacgtg 847561 aacctccata tccttatata cctcttccca ttcctttttc agcagattct tcgtggttgc 847621 cgtgcttctg atggtcctgt cttgaaagcc ggccgggtcc gcctttagct tttgcaaacg 847681 atgaacggtg ctgatcacgt ccttctttat ggttctgttt aatgcttttt gaatgatgta 847741 atactggtca ttttctctcg tctcataggt tgattggttt tccataataa ttcctttggc 847801 tctgatctcg attgtcattg acagctttcc gtttttttca gcggcatgaa aggatgcatt 847861 ggacttttga agctgaatgg atgcttgccc catttgattc ggcaggtcta ctatgaattc 847921 tggctggcgg gcttgattca gcaacatcag ggctgctgtc atgtgttcat ctttgaaaat 847981 atccatcaat ctgtcctttt taaagatcgc aagcccgtca attttcaaat tagatttgcc 848041 tttccctcca ggttttgttt tagatgcaga gatgaccggt gcatacggat cactgcctat 848101 ttctactaga tcagacatga atctgcttaa gaaaacgggg cggctcgttg cgataatggc 848161 cagctcccga atcatttccg ccggaaactg ttcaagctga acatcggtat ttaaaatgtc 848221 ccgcgcttct ccccggctga ctaaaatgag cgccgttaat ctgttctgcg gatttcgcgt 848281 taaaatatca aagactgggg caacgccgtc tctcgccata tcctctccaa taatgactgt 848341 acgtctgtgg gacgtattga ttgtccgtga caaggaggtt tgcagcttgt tgttcgcttc 848401 tctgatcgta gtgccggaag ctgaatcaac ataccatgtt tttgaaccgg cagttccgcc 848461 gccgccccct gtttgtccgc ctaattggcc gaccaaggga atctgcatgg ccactcgata 848521 ctgatctttt ttcttatcaa tggctgagct gacaacaaat gcaatgtcat tgatttctgt 848581 ccggtcccag caccccgtta gaaggataca aatgagaagc ggcaaaacac acttatatat 848641 tgttttcttc atcttttggg tcctctcttt tcgctccctt ctgtccgttg ccgcgcgaat 848701 acgtgcccgg ccttctggtc atcgtccacc aaggcgccct gacaaaaata tcttttactt 848761 catctcgttt aaacggagaa atcccggata aataaggaat gccgaaagat tgcagcttgc 848821 ataaatgaag cactaagata atcgtgccga gcataatgcc gaatatccca aaaatactcg 848881 ccaaaaacat aagcgggaaa cgaagcatcc tgatggagat agctaagtta aaccgcggaa 848941 ttgtaaatga cgcgatccct gttaacgata cgatgatcac catgggggca gacacaattc 849001 ccgcttcaac agcggctgtc ccaatgacta gggccccgag aatactgacg gtctggccga 849061 tggttttcgg caggcgcact cccgcctcac ggagagcctc aaaagaaatt tccataatca 849121 atgcttctat gatggcgggg aaaggaatcg gttcacgcgc agaggccaca ctgaacatta 849181 agtttgtcgg cattaagtcc tggtggtatg taataacggc aacataaata gccggcaaat 849241 ataaagcaac gaataaaaac atatagcgaa gccagcggat taagttagac atcaaataac 849301 gctcatagta atcttcactg gcctgcataa gctgccaaaa cgtaatcggg cctgttaaga 849361 caaagggcgt attatctgtg aaaatggcaa atcggccttc gagaagctgg gcggcgacgg 849421 tgtccggcct ttctgtgtat tgcagctggg ggaatggcga gtacgtgtcg tcttcgataa 849481 attcttcaat atatccgctt tctaagacag catcaatctt tatctttttg attctttttt 849541 ttgctttgtc aataaccttt ggatcggcaa gcccgtcaat ataggccaag acaacatcgg 849601 ttttggtttt cgtgccgatt ttaaaagaga tcattttaag ctgaaacgtt ttgacgcgaa 849661 agcgcacaag agcggtattg accctgaggc tttcagtgaa gccctctctt gaccctctga 849721 tggtcgattc tgttatcggc tcttcaatgc ttcttctttg tccgcctttt atatttaaga 849781 tcaggccttt tgagtgcccg tcggcaaata aaaccgcgtt cccctcaatg atggatgcag 849841 ccactttgct catactcgtt tctaatgcaa cacttgaaat tgatagagta ttttgcagcg 849901 cctcttcatg ttcatctatt tgatccgtca aatgcattaa gaaagggcgg agggcgtgat 849961 cctgaatatg ttcagatttt acaattcctt cgatataaac aataaatccg cacagcccgt 850021 ttccaaagtc aaattgtcta aatacgatgt ctgagcagcc ttctgttaat aaggtcagat 850081 tttcgaggtt ttccttcaaa ttgggagaga tcggtctgtc ctgattgtct tcaagctctt 850141 tgatgagctg aagcgctttg tcgcgtttat tcatagaggc tcaccctgct ttttaatgtc 850201 atattcaata agtgcttgtg acttttaggg taaccttgtc tgtttcatat attccagact 850261 aggatgaaag cgctataaaa aagtgttgac tacctgtata tacaggaata caatatgatt 850321 ataagttgta tatacaagtt ataaaaacgg atacggaggg gttggcatgg gggaactgaa 850381 caaatcggca cgtcagattg tcgaagcagt cggcggtgct gaaaatattg cagcggcaac 850441 tcattgtgtt acacgtttgc gttttgcttt aatagatgaa agcaaggttg accaagagat 850501 gcttgatcaa attgatgtgg taaagggatc attctcgaca aacggacagt ttcaggtcgt 850561 aatcggccag ggaactgtca ataaagtata tgctgaactg gttaaggaaa cggggattgg 850621 cgagtcaaca aaggatgaag tgaagaaggc ctcagaaaaa aatatgaatc ctttgcagcg 850681 tgctgtgaaa acgcttgcag atatttttat tccaatattg cctgcgattg tcacggcggg 850741 tcttttaatg gggatcaata acattttaac ggcggaaggc attttcttca gcacaaaatc 850801 gattgtgcag gtttatccgc agtgggcgga tcttgctaat atgattaacc tgattgcagg 850861 cacggccttt acgtttttgc ctgcgttaat cggatggtct gccgtcaagc ggttcggcgg 850921 caatccgctt ctcggcattg tgctcggggt tatgctcgtg catcctgatt tgctgaatgc 850981 gtggggatat ggcgcggcag aacaaagcgg agagatcccg gtatggaatc tattcggcct 851041 agaggtgcag aaagtcggct atcagggcca ggtgctccca attttgcttg cttcttatat 851101 gctggcgaag attgaggtat ttttaacaaa acgcacacct gagggcatac agctgctcgt 851161 tgtcgcacca attacgcttc tcttaacagg atttgcctct tttatcatta tcggcccgat 851221 tacatttgcg atcggtaatg tactgacttc agggcttatc tcggtgtttg gttcttttgc 851281 cgcactgggc ggtctgttat atggcggttt ctactcagcg ctcgtgatta ccggtatgca 851341 tcacacgttt cttgcagtcg acctgcagct catcggttca aagctcggcg gcaccttttt 851401 atggccgatg ctggcgcttt ctaatatcgc acaaggttcg gcggctctgg ccatgatgtt 851461 tatcgtgaag gatgagaaac aaaaaggcct ctccctcaca tcagggattt ctgcttatct 851521 tggcattaca gagcctgcca tctttggggt gaatctgcga tacagattcc cgtttatcat 851581 tgcaatggtc agctctggcc tggccggaat gtatatttct tctcaaggtg tgctggcaag 851641 ctccgtcggt gtcggcggcg tgccggggat tttctcaatc atgagccagt actggggcgc 851701 gtttgcaatc gggatggcta ttgtattgat cgtgccgttt gccggaacat acgcgtatgc 851761 gagattcaaa cataaataac aagtggggag cgggacgtgt tgaacgttcc cttttcccgt 851821 tttcaattta aatatggtgg tggaaacaga tgaaaacaga acaaacgcca tggtggaaaa 851881 aagctgtggt ttatcaaatt tatccgaaaa gctttaacga tacgacagga aatggtgttg 851941 gcgatctgaa cggcattatt gaaaagctgg attacttaaa aacgctacag gtggatgtgc 852001 tttggctgac gccgatttat gattctcccc agcatgataa tgggtacgat attcgtgatt 852061 attactcgat ttatcctgaa tacggaacga tggaggattt tgagcggcta gtgtccgaag 852121 cacataaaag agacctgaaa gtcgtcatgg atcttgttgt caatcatacg tcaacagagc 852181 acaaatggtt tcgcgaggcg atctcttcaa tagacagccc gtaccgtgat ttttatatat 852241 ggaaaaaacc gcaggaaaac ggttctgttc cgacgaactg ggaatcgaaa ttcggcggct 852301 cggcatggga gcttgacgaa gcatcgggcc aatactattt gcatctgttt gatgtgacgc 852361 aggctgattt gaattgggaa aatgaagagg tcagaaagca tgtctatgac atgatgcatt 852421 tttggtttga aaagggaata gacggcttta ggcttgatgt catcaacctg atttctaaag 852481 atcagcgctt tccgaatgcg gaggaaggcg acggccgctc tttttacact gacgggccgc 852541 gggtgcacga atttctgcat gaaatgaacg aaaaggtgtt ttcacattac gacagcatga 852601 cggtcggtga gatgtcttca acaaccgtag accactgcat ccggtatacg aatcctgaca 852661 ataaagaact tgatatgaca ttcagcttcc atcatctcaa ggttgactat cctaacggcg 852721 aaaaatgggc cttggcgccg tttgattttt tgaagctgaa ggagatccta tctgactggc 852781 aaacggggat gcacgcagga gggggatgga acgctctgtt ctggtgcaat catgatcagc 852841 cgcgcgtcgt atcaagatat ggagatgatg gcgcatatag ggtgaaatcg gcgaaaatgc 852901 ttgctacggc cattcatatg atgcagggca cgccttatat ttatcagggc gaggagctgg 852961 ggatgacgaa tccgaagttc actgacataa gctcctatcg ggatgtcgaa tcgctgaaca 853021 tgtatcacgc ctttaaggaa aaaggaatgg ctgatcaaga tattacagcc attttacagg 853081 cgaaatcccg tgacaattcc agaacccccg ttcagtggga tgctacggaa aatggtggtt 853141 ttacaacggg cacaccatgg ataccggttg caggaaatta ccgggaaatc aatgctgaag 853201 cggcgctgag ggatcagaat tcggtgtttt accattatca aaaattgatt cagattcgca 853261 aaatgtatga cattgtgaca gagggtacgt atgagataat tgcaaaggat gacccgaaca 853321 tttttgcgta tctcagacac ggcagcaatg aaaagctgct cgtgatcaat aatttttacg 853381 ggacagaggc ggcctttaca ctgccggact ctttagcgcc tgacgaatgg aaggcagagg 853441 tgctgttgac gaacgatgaa gcaagggaag ggcttcagaa catgacgctt cgcccatatg 853501 agtccattgt ttatcgttta acgaaaccgt gttaaactaa gctgggtggt ccataatgaa 853561 ggtgaataaa ttcatcacaa tttataaaga catcgcacag caaattgaag gcggccgatg 853621 gaaagcggag gagattcttc cgtctgaaca tgagttgacc gcacagtacg gtacatcaag 853681 agaaacggtc cgaaaggcgc ttcatatgct cgcgcaaaac ggttatatcc agaaaatcag 853741 gggaaaaggc tccgtcgtgc tcaatcgtga aaaaatgcag tttcccgttt cgggccttgt 853801 cagcttcaag gagctcgcgc aaacgcttgg caaagaaacg aaaacaactg tacacaaatt 853861 cgggctggag cctccgtcag agctgatcca aaaacagctc cgggccaatc tggatgacga 853921 catctgggaa gtcatcaggt ctagaaagat tgacggggaa catgtgattt tggacaagga 853981 ttactttttc agaaagcatg tccctcacct gacgaaagaa atttgtgaaa actccatata 854041 tgaatatata gaaggagagc tcggtctttc gatcagttac gcccaaaaag aaattgtagc 854101 cgagccgtgt acggacgagg acagagagct gctcgattta cgcggctatg accatatggt 854161 cgtggtgaga aactacgtct ttttggagga taccagtttg tttcaatata cggaaagcag 854221 acaccgtctc gacaaattcc gatttgttga ttttgcgcgg cgggggaaat gagagaggcg 854281 cctgcctgcg gcagcgcgct tttttgtttg gtatcaaaat tgatactatc caacaaaaat 854341 gtgcgtactt ttacttttta tcataatggc tacaatagag atgagagtaa tctaaaggag 854401 aggtgtttta catggcagat ctaaagacac aaattctgga tgcatacaat ttcaggcatg 854461 cgactaagga atttgacccg aataaaaaag tgtcagacag cgattttgaa tttattttag 854521 aaacaggaag actgtctccg agctcactcg gccttgagcc ttggaaattt gtcgtcgtcc 854581 aaaatccgga attccgcgag aagcttcgtg aatacacatg gggcgcgcaa aagcagctgc 854641 cgaccgcaag ccatttcgtc ctgattcttg cgcgtacagc gaaggatatc aaatataatg 854701 cggactacat caaacgtcat ttaaaagaag taaaacaaat gcctcaagac gtgtacgaag 854761 gctatttaag caaaacagaa gaattccaga aaaacgattt gcatttgctt gaaagtgaca 854821 gaacattgtt tgactgggca tcaaaacaaa cctatatcgc gcttggcaac atgatgactg 854881 ccgctgcgca aatcggtgtt gattcctgcc cgatcgaagg cttccagtac gatcacattc 854941 accgtattct tgaagaagaa ggccttctgg aaaacggaag cttcgatatt tctgtgatgg 855001 tggcattcgg ctaccgagtg agagaccctc gtccgaaaac aagatctgct gttgaagatg 855061 ttgtgaagtg ggtttaaaag aagaaagctg ctcgcatagc gagcagctct tttttatgcc 855121 tgattcgctc tattctgttt tctcctctga tgtaagtaca ttgccgttcc gagtgcgctg 855181 atcagaaatc cggccaacag gatcgagtac atggatgtgg ctgtgtccgg aagcaggccg 855241 ccagccggac cgtctgttcc tgatccgccc gaaccgtttc caccagagcc gttagtcggt 855301 tgagtgccgg gaggcgtatc atttcctccg tttccgtcag ttggctgttt tccgcctggt 855361 ttgtcggagc ctccgccatg attgccgtca tcaccgcctg tcggttgatc tgacgggaat 855421 gccggcggtt tgttgtttga accggaattt aagatcgtgt attcgctgaa gtggtttgta 855481 tatcctgtca ccatatcatc atcgactgat ccgtgacctg tctttgtgaa agctttcttt 855541 tttctatcga cgtgataaat ggcagggtta tgggcttctt caatatcaaa catgcgaagc 855601 gaaagctgta cgggctcctt gaatgatttt atttcttttc ctttttgctt cactgtaaag 855661 tcatatacat ctgacagtga cacatccaat tctcccgtag acttgattcc gattgcagtg 855721 tctgcggttt taaggttcgc cattggcatc ttcatgctgt accagtagtt gaacatcgtc 855781 aatgaaggat ctgactctct ttctttcaaa agtttgacct gatctttttt cactttaaga 855841 ttgataggct tctcttgaga tccttcatgt attccataat agacaaatgg cgtgttggca 855901 tttttagcat aaatcgcaaa tttgtcttca tcaagtgtcc agctgccgtc cttctgcttt 855961 gtcggcagga atacttcttt gattcgtcct tcaactttag gagagacctt gtttcctagt 856021 tttttcagct gttcggtgaa aatctcataa tcaacgtagc caaggtcttc accatgggag 856081 gcttctgtaa agacagaata tccgtctcct ccggcaccga caaaattatt tgttgccacg 856141 cggtaggtat catccgtatt tatagcaact ttgtctccgt taggcgattc aattttcact 856201 tctaacacac ggtgtccagg tttgttgttt aatgtaaagg tatattcgat tccggccacc 856261 tgagggaaag cgccgccgcc attttccaca ttgcttaggc cttgttcaag ggcttcttta 856321 atttgttttc cggttaaatc ggccacgtaa agcgtattgc cgaacggcat cacgttgagc 856381 acctcgccga gtgtgatatc acctttgtca atgcctgctc tgatgccgcc gccatttgtt 856441 atcgctattc tggcgccggc tgcttctttc gcttttgcca gcataccgtc cgcgatgaag 856501 tttccgagat tcgtttcttt cgtgcgcaca tgctcacgct ggccgtcaag cgccacatcc 856561 gtgtagccga ctttttcatt tttcacgtcc tctaattcat ttttgaactg atcgagctct 856621 tgttttgctt ctgggttttc ttctgtatgt tcatcaattg gcagcacgct cagatttgat 856681 ttatctgttt gcacaacgcc tttttcatca aacgcgacat caacgcgccc caagaattgg 856741 ccgtattctt ttgcctgcgc cacgatcgtc ggttcttcgt tgttcacgac ctccattttg 856801 tctacgaggg tgtgagtgtg tccgccgatg atcaaatcaa tgccttttac ttttttggct 856861 agctcaagat cccggttatg tccgatgtgg gttaaagcaa taattttatt taccttttct 856921 tcttcttgaa tcgctttgac ggtgttttgt gctgtttcaa aggcatcatt gaatacgatg 856981 cttttgcccg ggcttgatgt ggtggctgta tcttctgttg tcaggccgaa tacggcgact 857041 ttctccccgt caacgtctaa cagaatgtaa gggtgaatgc cggcctcttt cttttcacct 857101 gccgtaaagg tttgcggctt tttgacaaat gatttcagct tgggctcatt tgacacatct 857161 acgtttgcac tgacaatcgg aaattccggc gcttcaaagt gatagcggtt cgccggatca 857221 acggttgcgc tgtttccgct tagaaaatca gaaagcaccg tcgggccttt gtcaaattca 857281 tggtttccga aggtcatggc gtcatagccc atcatgttca tcattttcag atcggccaaa 857341 ccgttccatt tagtaaaata cagatcgccg gaaaacacat ctcccgcatc aaggagaata 857401 ttgtgatttg tttcgctgcg tacttcgttg attttcgtca ttcgtctcgc tgcatcatcg 857461 agatgggcgt gcgtatcatt ggtgtgcatg acggtcagat cccacagtcc gtctttagga 857521 ggatctggat ttgaatcatc atcgaattgc agcttataca caccatagcc ttcattcgca 857581 gacttgccta cataagcgac atcgtctgct ttatcggcaa atggcttggc caaaagcgag 857641 gattcaaacg tcagattcgt gccggaaaca ggcgcgattg accagttgtt gtctgctttt 857701 ggattgactg ttttttgttc aataatgtaa tccatcagca cctgcctatt ttcaactgca 857761 gagccgtgga caattttatc gctcgtcaga tgagggaacc cgccgcctcc ggacgcacga 857821 tagttattgg tgactacgag aaattcctgg cttgggctga tcggcttgcc ttcataggaa 857881 agattgatga tacgggatga atccgcattg atcacttttc cgttctcatt gtatttagcc 857941 ggttttgtca catcgacctg atatgtgaca ccgtcaatca cgtcaaaatt ataggagcgg 858001 aaattctcgt tcagcaaggc ctggtcgccg cctttagctg gatcaatttg attgaattgg 858061 cctgctgaca tctccagcca gtccttgacc tcgctgcctg tcagcttgac gatttgaaca 858121 gtattatcgt aaagatacaa gtcaccgaca tttttaatcg caagatctcc ggctggaatg 858181 tttgtatagt aattggctcc gtttctgccg cctgctttaa acggcgctcc agcggataaa 858241 atcggcaggt tcttgtactc ggtatccttc atttcttttt cagcgtacca cttttgcgcg 858301 tcagtcacga tctgaatgga aggatcatct ttgacctgtg caaagaagct gttaatatct 858361 gcttcggttt tgccgactgg ctttcggaca tactccagtg tgttttggtg tgtttgctga 858421 atggtgtttg taacggtttc gtttcttgat gtgacgttgc cagcaataga ttcaatactt 858481 cctttggaat ctgctacctt ccatgagccg tccgcctttt caagcttgag gtcaatcacg 858541 cctaaatatt tgccccagct gcttggcatg acgacaggaa tgccgttaat tgttcccttt 858601 tccacattga actgagcaac acccgcatac tcggcggaag gaaagagtcc gtgctgatgg 858661 cccgagataa tcgcgtcaat gcctttcgtt ttggtggcaa ggtcaaacac ggcgttttct 858721 gcgcctgatg attgcgcctg cttttcaatg ccggtgtggg cgagggcaat aatgacatct 858781 gcgccttccg ccttcatttt cgggatcgtt tcattggcgg attctacgat atcctgcacc 858841 tgaacttgcc cctcgagatt ctttttgtcc catgtcatga tttgcggcgg gacaaagcct 858901 atgtagccga cttttacttt ctgctcatta ccgttttcat caatgagggt tttttcatta 858961 atcacatacg gcgtataacg gttttcgccg ctagttgttt tgacgttggc atttacaatc 859021 gggaaatcgg ctcctttgat tgtgccgtcg agaaagtcga gcccgtagtt gaattcatga 859081 ttgccaagcg ttccggcgtc gtatttcagc gcattcatga cgctgataat cggatgggtt 859141 ttcgtgccgg agataatgtc gtctttttga tatttcaccg cgtattcacc cagcggattc 859201 ccttgaatca agtcgccgtt atccacaagc agggtgttag ggttttgctc gcggtgcttt 859261 tggatcaatt gcgctgttct cgccagaccg aaatccgccg tttctttgtc gctgtagtaa 859321 tcgtaatcca tcatgttggc atgaatatca gtcgtagcca aaatactcag atgcacctga 859381 ggagccgcgc tttcttctgc atgaatgggt ggtgttggga ggattaggct aagtatcata 859441 attgggggca aaagaatacg gagaatgttt tcgacgtgtg ttcgtctttt ctgtattctc 859501 accagttctc cacctttcaa cgaaatttgt gttacagctc ctattgtaag aatattttgt 859561 aactatttgt aggtgtttct ttatgattat tgtaaaaggg agaaaaatga gtattatgta 859621 gcagtatcaa acgacaaata ctgggcattt atgcttatcg tttgtcacaa tcgcggaatg 859681 tttattttag tgtggctggg gtagagtgtt ttatgtagac atataaagcg ggaggttatg 859741 aatcatgggg aaaaaaattg cagttgtttt aacatattat tttgaggaca gcgagtacac 859801 tgagcctgcg aaagccttta aagaagcggg acatgaactg actgtcatcg aaaaagaaaa 859861 aggaaaaaca gtaaaaggca agcagggaac agcggaagtg acggttgacg cgtccattga 859921 cgacgtaaat tcttcagact ttgatgcgct tttgattcct ggaggatttt caccagacca 859981 gcttcgcgct gacgatcgtt tcgtccaatt tacaaaagcg tttatgactg acaaaaagcc 860041 ggtatttgcc atttgccacg gcccgcagct tttaatcaat gcgaaagcgc tcgacggccg 860101 aaaagcgacg ggctatacgt ccattcgtgt tgacatggaa aacgccggtg ccgacgttgt 860161 ggacaaggaa gtggttgttt gccaggatca attggtcact agccgcacac cggacgatat 860221 accggcattt aaccgcgagt cattggcatt gcttgagaaa taagaaaaaa cggacgctct 860281 tgggcgtccg tttttttgtt gcttaggctt gagcacctgt cagtttcttg tacctgtaat 860341 acaagaaagc agctgcagcc gttccgatga ccgcaatgcc gaagtcgaat atgaaaatat 860401 gggcgatgcc ccccgctttt gcgataagcc ctgttgcaat cggcagcaga atcgatgcaa 860461 gacttgaagc agtcgctaca attccggtaa cggttccttt tcgcttccag aaaagctctg 860521 tcattaacgt aatggtaatt tgaaacacac ccgcagttga aaagcctaag aaaaaggcag 860581 tgatgtccag cacaactggg atatgaacgg tcagcatgac tgcgagcgta cataaagtaa 860641 taataggata taagagcgtt atgaagacag gtttgaccca tctattcagc aaaacggcta 860701 ataataaaac agatgccaga gatcctatac tataatagct cagcaattgt acagatgctg 860761 attcagctaa accggctgcc ttttgcgcgt agctcgggag ccagatttga gaaaccgtaa 860821 ataaagccgt ggatgtaaaa ccgatgataa tcagtgcggt gccttccttc tgaaaaacgg 860881 gttcagacaa gaaaacggga gattcctgtt ggccgctatt agttggtttc ttatgttttt 860941 taggaaacga aagcgttgat aaataaataa tattcaggag atagaccgct gccggcagat 861001 aaaaagcaaa tccgtaaaac atgctgtggt ctgctaaaaa tgtgatcaaa agcggcaaaa 861061 gtgcggcccc cacagacata aaggctttaa ccaagacatt tgccgaaccg gaagcagacg 861121 gaaagagctc ggttagggcc ggatatgttc cggcatccat ggctgaatta gcgactccgg 861181 ctaataaagc gaacacaaac gccagctcat agctcggtga taaaggaata ccgactaaaa 861241 agacggccat aattcccgca gaagcgacaa caagcggctt tctgccgatt ttatctgata 861301 gaacgccgga aatgccgtat gtcagcagtt tgccaaaccc gatagcggca atgacataac 861361 tgatgccggt cggatcggta ttccactgtt ttgttaatga agacatattg gatgcgagaa 861421 tgatgttgac catccccaga aagaagtagt tgatatacat tccggatgct gttttgatag 861481 atgtcgtttg catgcttgta ctccttcaaa tcttattcga acactttgct gttttggttt 861541 ggggaaatga taaaaaagac tcgccgagtt tccggccagt ctccattatt tacgaagcga 861601 ggctaattct tgagcaatcg cctgcatttc acttgggctg aatgattctt ttttcatcac 861661 cattctgtga aggtacgtga ggtcttcaat cttctcatca ctgaaatcct ccgctttgat 861721 tacgccgacg ttcagcatgt tcagcttttg ggaaatctct tcaatcattt gagttaatgt 861781 ttctgtattt gggctggaca aagggttcca tcctttctat gcgcaatata ggtatgtttt 861841 attctaacag aattccatca gaaaaaaacc ctattctaaa agcaggctgt tcattccaaa 861901 aaagtgaaga catcagttga aaagaaaatg aacatcctac taagatattc atgaaggttt 861961 ctttttagag aaataggggc aaagaatagg gaggttgcac atcatgataa gcgtgttatt 862021 tgtttgttta ggtaacattt gccggtctcc gatggcggaa gcgattttta gggacctggc 862081 agccaaaaaa ggattagagg ggaaaatcaa ggcggactca gccggtattg gcggctggca 862141 catcggcaac cccccgcatg agggaacgca ggagatattg cgcagagaag gaatcagctt 862201 tgatggcatg ctggcgcgtc aagtcagcga acaggatctg gacgattttg attacatcat 862261 tgcaatggat gcagaaaata tcggaagtct cagaagcatg gcgggtttta aaaacacctc 862321 gcatatcaaa aggctcttgg actatgttga agattcagat ctggctgacg tacccgatcc 862381 ttactacaca gggaactttg aagaggtctg ccaattaatc aaaacgggct gtgagcagtt 862441 gcttgcatcc attcaaaaag aaaaacaatt gtgagtgaaa ggagaatttg catgaacaac 862501 gaacgtttaa tgctgaaagg gatatttctc ggagctgcgg caggcgcggc gttatcactg 862561 ctccataagc cgacaagaca ggcgtgcggg atgagatggc tgacatgcaa gcataaactt 862621 tcactgtaca aaagcaaccc agagctgtta aaaaacactg tcatcacaaa agtggatgag 862681 gccaaaaagc tcgcccgaac gctttcaaag gaagtcgact ttgtgaacca gcaggtgaaa 862741 gagctgaaga aaacaacgcc gcaagtgatg gaactcgtgc aagaaacgaa agagcatttt 862801 tcaaaaaaat gatcaaacat gcgaggtgag acgacatgag ttttttgaaa gagcttttca 862861 gcagatacac ccttcatgaa ggacaaagta aatcagcgga gctggcgtat ttttttctat 862921 tgtcactgtt tccgtttttg atttttatgc tgacgctcac cgcgtatctt ccgctttcta 862981 ccgatgatgt tttaggagtc atagaacaat atgctcccgc cagtgcgatg tcactcgttg 863041 aatccattac ccatcaaacc ttaaataatc gaaatggcgg tttgctgtca ttcgggatta 863101 tcgccgcatt atggtctgcg tctaatggaa tgaatgcgat cgtccggtcg ctgaaccacg 863161 cgtatgatgt ggaagaaaac cgctctttta tcattgttcg tctaacctcg atttttttga 863221 cgattgccat ggtatttacg attttagtgg ctttgcttct gccggtattt ggccgggaga 863281 ttggaaggct cgcttctgac tttgtcggcg cgtcggatct gtttttatcc gtctgggccg 863341 ccattcgctg gggtgtcagc ccgcttgtgc ttttgattgt tttttccgcg ctgtatgtga 863401 ttgcgccgaa caaaaagctg tctctccggt ttgtcatgcc gggtgcggtc tttgcgacta 863461 tcggctggat cattgtcagc acattgtttt cattttacgt cagcacgttt gcgaactata 863521 gcgccactta cgggagcatc gggggaatca tcgttctgat gatttggttt tacttgagcg 863581 gcattttaat tatcctaggc ggagaaatca acgctctttt acataaacgt aaaaagcttc 863641 ctgatgaaaa tccctaccat tagcgcaccc tataaacgaa cttcggttca aaaagaagtc 863701 ggggggatat cgtgatgacc aagcatacga aaaaaggcgg aagccataac aaacaaaact 863761 cgaaaagcaa atcgagccat aaaacaagcg gaagcgccaa cggacaaaac ggctaccatt 863821 agcataaaag cctcctgaca tgatgtcggg aggctttttg attaagaaga tgaagaatag 863881 gtttcagccg gtgaccagct tttcggtttg cccagcacaa gggccagcca cacagagcta 863941 agcgtgagag taatgaagta gaacaagttt gcgctttcaa atgtctgcat ataccagccg 864001 ccggcaactg ggccgaggat gctaccgaga ctgaatgtaa tgccgcaaag caggtttccc 864061 gccggcagga ggtgaggcgg aagaaggtct gtcatatagc tgatgccaag tgtaaaggtt 864121 gatccgactg ccattcctgc aataaaaaag cagccgccga tcacgtaggg cgaaggaaat 864181 acaccggcga tgaaaaagca aagagcccca gtcagtaaaa tcaccagcag cacattccgc 864241 ctgccgtatt tatcgctgag gatgccgagc ggaaactgaa agataatgct tccaatcgca 864301 aatgcgggaa ggatgatcgc tactgcgtct actgatatcc ccaaacggag cgcgtacacc 864361 ggaaagcttc cgttcagcgc cgtttccaga aagccatagc caaatgtagg cataaaggca 864421 acccacccaa acagcatggc ctgataaaat cgcctgaaac tattgtctga tttggtttca 864481 tgaggactgg tttccgggta tgcattttgt agaaagaaaa caaaaagcca cgcaaacaga 864541 ctgatgcagc cggacacgat aaaaggaagc gacggactca gcttgacaag cggcaccatg 864601 aacgggcctg cggcaaagcc aaggccaaag gaaagcccat aaatagacag gtttcttccg 864661 cgattttgtt ttgatgacat ggaggtcacc cacgtttgcg tagaaaagtg aagcatgtgg 864721 tcgccgattc caatgaacag gcgaagcagg aaccagaccc aaactgactg aagccaaata 864781 aatccgaata agcttaaaat gacaatgctt ccgcccatga cgatcagcgg cttgaacccg 864841 agctttctga gcggtgcttc cataaacggc gaagccaaaa gcacaccgat atacagcccg 864901 gtcgcgtgca ggccgttgat agcagcggat tctccatttg tttcaaaaat gattgaaatg 864961 acaggcagca gcatgccttg tgaaaacccg gaaatggaaa cgagcaagac aaggataaag 865021 aaatgaaatc gtgacatcgt gtcagttctc cttatatgga atctatgttg atcgtacaac 865081 gttttccaaa agcaggcaac ctgaaaaaag cctatatcac gctatacatt tgccctcgtg 865141 taatcatgaa ggtttttgtg aagaataaaa ataaaacaag tcataaaaaa ggagctattt 865201 caccatgaat cgtatctttt ttattttagt ggcggccggt gttccgcttt ctgtgattgg 865261 cagtttgatg cattggcctt ccgcggttct atttgcagtt tattgcgtga cgattatcgc 865321 gcttgcaagc tatatgggga gggcgacaga atcactgtcc atcattgcag gaccgcgtat 865381 cggcggtttg ttgaatgcaa ccttcgggaa tgcggtggag ctgattattt ccctttttgc 865441 attaaaagaa ggcctgacag gaatcgtgct tgcctcttta accggttcag tgctggggaa 865501 cctgttgctg gtagcgggcc tatcgttttt tgtcggcggt ttaaaatata agcggcagga 865561 atttaatatc catgatgccc gccataactc cgggcttctg atttttgcca tcattgtcgc 865621 ctttgtgatt ccggaggtat tctctgttgg tatgggaaac gccagcaagc tcaatttaag 865681 catcggcatc agcatcatta tgattctgtt atatgtggcg gcgctgtact ttaaacttgt 865741 cacgcatcgg ggcgtttatc agccgaataa tgccgctcag actgaagaag aggaagagcc 865801 agaatggtca gggaaggttg cgacgattgt cttgtttgcg gcaacgattg tggttgcata 865861 catatccgaa aacctggtcc atacctttca ctcggtggct gaacagttcg ggtggagcga 865921 gctgtttatt ggggtcatca tcgtggcgat tgtaggaaat gcggcggagc atgcgtcagc 865981 gattattatg gccttcaaaa ataaaatgga cattgctgtt gaaattgcag taggctctac 866041 gctgcagatc gctatgtttg tcgcaccggt tctcgtcatc tgttctatct tttttccgac 866101 aagcatgccg cttgtattta cattgcctga gctcgtcgcg atggtatcag cggttctctt 866161 gatgatcgcg atttcgaatg acggggattc caactggttt gaaggggcga cactgcttgc 866221 tgcatatgtc attatggcga tcggcttttt ccttctttaa cctgaaaaaa tgatggataa 866281 caacaaagcg ggatgaaaag actaagggaa aatgccatag aaagagtgat atgatgaaaa 866341 agctatttca ttccacactt attgtgttgt tattctttag ttttttcggc gttcagccca 866401 tccacgcgaa aaagcagttt aaggttccta attctgtcgc aagcatttca aaggaaaaca 866461 cgtatccgaa tgcttcacag gatcagccaa tgcttcagcc gagcaagctg gcaaaggaat 866521 tgctcgatca ttctgaggta aagattgaaa atccgcatct catcaaaatg ctgaatgaat 866581 ccaacatatc cggcacaccg cttgcagtag ggtaccgggc gacaatattt ctcgggaaat 866641 gggcgctcgg ctatgaatca aatgaaacag tcgcaaactg ggaatataaa aaaatcaata 866701 caaaccgtgc ggataaccgc ggcgggaaag aaacggctga aatgcattat gcccaggaac 866761 agcagtacag agtgaagggc ggcttgacag ctaaagttcc aaatgctgaa gatgtcaaaa 866821 gcatgatgat gcaaaaagca atgaagaaaa cgaacctccc gcttgcattt gagacggtca 866881 tcggggctgg cacaaaacgg gatcagattt ataaagtcgc tcctaaaaaa atcggttatc 866941 tacatgcata tgcaccggct gtgaatgaaa aaggaaaagt gacttacgga gaagtgtact 867001 tagtgctgaa aggaaataaa cgaaaactcg tcgtgaaaaa tgtcacgtca cagggaatcg 867061 gcgcgtggat tccggttcaa gatcatgtca cgtttggctt tcagctttcc tcactgccaa 867121 gataaataaa aaactgattc caactcggaa tcagtttttt tgtttattgg gttctctcga 867181 ttcggaccgc ttcctcaagc atttgcacat tgttttggta gagctggcga acgagaaccc 867241 gtcttactgc aaggctggca ctgaaataat catcatcttt caccatgcct ttaaccgtaa 867301 attcgacgcc gcgattgatt ttattcaatg cggtgatgcc gtggatttga aacggttctg 867361 tcggattgcc gaattcatcc cgcttcaatg aatcacgaag ctcttcattc agcatgtcac 867421 atgcctcttc caacacgctg tacacgcggt ccggatcttc tttaaagctg ataagaaagg 867481 attcggtaat ccgcataaaa tcaatattat agttctctat ttgtctgacc tcgccgttgc 867541 tgatggtgag cagcttcccg ctccattccc ggatttgcag cgagcggagg ccgatttcct 867601 ccactgtccc gttgaacaag ttgttgacgg tgacataatc gcctttgtgc agctggcgtt 867661 catatattaa gaatacacca gccagcacat ctttgatcag cgattgggcg ccaaaaccga 867721 tcacgatacc tgctacgccc gccccggcca atatcttgcc gaaatcatgc acaaataaag 867781 aaataacgta aaagataaaa ccaattgttg ccgtatactg ggtgacagaa cggacaaggc 867841 tttcaatcgt tttttccttt ttttcttcaa taaagtccgt ccgtttaaaa aatagctgta 867901 ccagccggtt gatgataaag acaccgatcc aaaggataac ggcaacgagg agaatatcga 867961 cgattttatt ttgaaaaatc tccgtaagtg tttctttcat ccgcatctaa ctcctggctt 868021 gacgttttgt gaagtctgta tcctgataat aactgttttt gacaagaaca ttcggtccga 868081 ggcaccggac attcgggcag tggcaactca gttctttcgc aagcttggtc tctctccact 868141 tttcataggc ggaagggagg ctgtccgtct gaatgttgcc aagcggcggg gtatcaccga 868201 aatcggtcac gataatgttt ccgtcgaaaa tgttcacatt caggcgggat cggccgtcag 868261 ggtcatttcg cactgtgacg tttttcgccg cgcgaagccg gcgaagcagc ttttggtcgt 868321 cttcgtccgg actgcaggca taaaacggca gcgttccgaa cagcatccac gtattttcat 868381 cacgaatatc cagcaagcgg tgaatggcct gtctcatctc tttcaggctg agggattcaa 868441 gagcgcttgc gaaatcgctt ggatacattg ggtggacctc gtgacgctga catttcatat 868501 cttctgtgat ttggcggtga atatgctcaa tatgcggaag tgttcgtttg ttcagcatcg 868561 tttccgcaga taccattact ccggcatcca cgagcgtgcg gctgttttcg atcatttttt 868621 caaaatagcg cgcgcgctgt tcgaaggtcg gttttctgtc catcatggca aagccgattt 868681 cagcaaaatc ttcaactgtt ccccagttat gtgaaatatg tagcacatcg agatacggaa 868741 tgatccattc gtaccgctcg atgtcgaggg tcagatttga attaatttgt gtccgcacac 868801 cccgttcatg ggcatatttc aataaaggaa caacatattc ttttactgat ttcaacgaaa 868861 gcatcggctc tccgcctgtg atgctgatgg atctgaggcg cgggatttcc tccagccgtt 868921 ttaacagaag atctattggc agagcattcg ggtctttagg ctgcaatgta tagcctacag 868981 cacaatgctc gcatctcata ttgcacagtg tcgttgttgt gaattcaacg tttgtcagct 869041 gcatgtctcc gtattggtca acatccatat aggcttccca agggtcaaac tcgggcgtaa 869101 tcggacgcag cttcgtgttt tgtgtcatga ctatctaact cctttataaa tgggcatact 869161 aacgctgcca acagttaatt ttagacctga tttgccaaga tcgcaagtag cgcggcgatt 869221 gaaaaacggc aaaaaatgag ctaccataat aaaaaatgaa tggaggaaca gaatggggaa 869281 cgccgtaaac aataaagatc agcagattga ttatttaaag aacagacttg acatgtttat 869341 gaacgtcatc gattcattag accctgaagc aaccgacgtt gaagatatag acaggcttat 869401 cagcatgctt gatgacctgg aagccaaata cgaacgtttt aaaaaagatt gggaataaaa 869461 ccgcgtgccc gccgcggttt ttttattggc ataaagcaac agtataaaac aaagtctcta 869521 tctgtaaaat aagaaaaaat gcagaaggag cgctggccat gaagtggatg tgttcaatat 869581 gctgcgccgc cgtattgctt gccggaggtg cagcacaggc ggaagcggtg ccgaatgagc 869641 cgattaattg gggctttaaa cgaagtgtca atcatcagcc gccagatgcc gggaagcagc 869701 tgaacagttt aattgaaaaa tatgacgcgt tttatttagg gaatacaaag gaaaaaacga 869761 tttacttaac gtttgataac ggatatgaaa atggctatac gccaaaagtg cttgatgtct 869821 taaaaaaaca tcgcgtaaca ggaacgtttt ttgtcaccgg gcatttcgta aaggaccagc 869881 ctcagctgat caaacgaatg tcagatgagg gccatattat cggcaatcat tcctttcacc 869941 atccggattt aacgacaaaa acagctgatc agattcagga tgaacttgat tcagtcaacg 870001 aagaggttta taaaattacg ggaaagcagg acaacctgta tttgcgtccg ccgcgcggcg 870061 tgttcagtga gtacgtactg aaagaaacga aacgcctcgg ctatcaaacc gttttctggt 870121 cggtcgcttt tgttgattgg aaaatcaaca accaaaaggg aaagaaatat gcctacgatc 870181 atatgatcaa gcaggcgcac ccgggagcca tttacctgct tcacaccgta tcgagggaca 870241 atgcagaagc gctggatgac gcgattacag atctgaaaaa acagggctac acttttaaaa 870301 gcattgatga tctgatgttt gagaaagaaa tgaggctgcc gtctttgtaa aagagaaaga 870361 cctctcctta aacggagagg cttttcttta ttttatacat ttaatcagtg cggcccagtc 870421 cagatccccg aagcctttct caatcccgct ttcaaaatgg ctcttggcca gctcggcaag 870481 aggaagattt gcagaaaccc gttttgcggc ggcgagtgcc aggttggtat ccttcagccc 870541 taaagacatt ttgaagccgg ccggctcaaa tttctgctcg gccataatgg ttccgtaatt 870601 ttgatagact ggagaaccaa agagcgcgct ggcgatttct aaaaattgtt tttgttctaa 870661 gccgtatttc tccatcatta aaaaggattc agataacgcc tccagcatgg acacaagcaa 870721 gaaattaatg ctgattttgg ctgcatttgc cgtcttgctt tcttcgccga cgtcaaatat 870781 ctgctggctc aggctgtcga gcagaggctt ggcagcttgc tttgcttccg ccggtccggc 870841 tgttatgata cggagcgcgg ctttggctgc ggcatccggt ctgccaagga caggagcggc 870901 gagaaaaaat tgtcctttct ctgcatgagc cgctgcgagc ttttctgaga actcaacact 870961 gattgtgctc atcgagatgt gtatgccgtt ctctgctaat ccttcaagca gcccgtcttc 871021 tccgaatgtc acggtgctga cagaatcatc atctgcaagc attgtgatga caatatcagc 871081 ggactttgcc gccagccgcg gcgtatcagc tgcctgtgcg ccttctgtga caaggtcttc 871141 tgtcttttgt ttcgtccggt tatagacagt caattcgtag cctgcttgaa gaacatttcg 871201 ggcaatgggc tgtcccatat tgccgagtcc gatgacagca attttcaatc taatcactcc 871261 ctgaatattt tttccattat aaacaatatg aacagaatat gcatagcgat cggcttacaa 871321 caaaaaagaa cagctgctcg ctgtcctcat ttaaaaatat tgaaccatcc tttatgtaca 871381 aaccaaatca gcattccaat cacaagcgcg gccatcaggc caagtacagc gaaatatccg 871441 tatttccaat gcagctccgg cataaagtcg aagttcatac cgtatacacc ggcaataaag 871501 gtgagcggga tgaaaatggt tgatacgatc gtcagtgtca tcataatcgc attcatccgg 871561 tttgagttta gcgtcacgta gctgtcacgc aagtcggacg tcatgtcacg gttggattcc 871621 acaatttcag acaactttaa caaatgatca tatatgtcgc tgaaataggc tttcgtttcc 871681 cgctgctctt tcacatggtc aaggcttaaa atccggtaga gcaaatcacg catcgggata 871741 atcgtccgtc tcaaatgcaa taggtctgtt ctgagatcaa acacctcgtt catcagcgtt 871801 ccatacgttt tgtggggacg gctttcttca atttcattca gccggtcttc aattttatac 871861 acgagaggaa aatattcatc aacaagctga tccatgatca tataagaaat atgcccgggc 871921 ccttttttca atatgtccgg tgaagcatac aaacgctccc ggactttagc gataccgggc 871981 gtttcgtgta aatgaaaggt gacgacaaat ttttcgcctt gaaagatatc gacttcctcc 872041 gtctcaagtg tttccttatt cagcgcatga atcacgtaaa aacgatagcc gtcataatgg 872101 tcaagctttg gccgctgcat atgctggaag caatcctcaa tggcaagcgg gtgaaaatga 872161 aaaaaatctc tcaataacgc cgtttccgta tcctccgggc cgtaaaaatc aacccagtac 872221 catgcaatat caggctgttc cactcgttcg atcggtatat ttttcagcag ctgatgctct 872281 gttgtgattg cggtaatgtt gatcataaac aaccctccac ctgccattat atcatgcggt 872341 ctttatgaga aaagtatacg gtactctctg cctaattcca gcggcatgtt atactgaaca 872401 aaaacggaaa aaagggtgga tctcatgtgg aaggaaaaag tatctgtcac gcctccgtat 872461 cattttgacc gcgtgctgga caggctgtct ttagaccccc tcaatgctgt tgatcgagag 872521 gcgagggaag tccgtgtgcc aatcagaaat caagcggggg acgtatgtat tgtaaaggta 872581 caggcgttag gccatgcggg cgagcctgag ttcctcgtca gcggggaaac ggatcaggga 872641 gaaatgatga aggaaatcaa gcggattttt caatgggaaa atcatttgca gcacgttctg 872701 gatcattttt caaaaacgag cctgtccgcc atttttgaag agcatgccgg gacgccgctt 872761 gttctggact acagcgtgta caactgcatg atgaaatgca ttatccacca gcagcttaat 872821 ctttccttcg cttacacgct aacagaacgg tttgttcatg cgtttggcga gcagaaggat 872881 ggcgtgtggt gctatccaaa gccggaaacg attgcggaac tcgattatca ggatctgcgt 872941 gatctgcaat tcagcatgag aaaagcggaa tacaccattg atacatcaag gatgatcgca 873001 gaaggcacac tcagcttgtc agagctgccg catatggcgg atgaagacat tatgaagaaa 873061 ctgatcaaaa tcaggggtat cggcccgtgg accgtgcaaa acgtcctcat gttcggactt 873121 ggccgtccca atttattccc gcttgccgat atcggcctcc agaatgccat caaacgccac 873181 tttcagctgg acgataagcc ggcaaaggat gtcatgctgg cgatgagcaa ggagtgggag 873241 ccttatttaa gctatgcgtc tttgtatttg tggaggagta tagaataatt cgtctgacaa 873301 tgaaggaaat cctgcaaacg tgttatacta gaaagatgtg aaaaaaccat ttcactttct 873361 gccatccgca gaaagcttca tatagaaacg gagagaacaa cgtgaaccaa caaaagaaac 873421 aggcgcccgt cgaactgaag gtcggacaaa cttttccgct gacgattaag cgtctcggca 873481 ttaacggaga aggtgttggc tattttaaga aaaaagtcgt cttcgtgccc ggcgcgcttc 873541 ctggcgaaga agttgttgtg caggccacaa aggtccagcc gaagttttcg gagggccgca 873601 ttaagaaaat ccgcaaggca tctgagcacc gggtggcacc gccttgccct gtttatgaac 873661 aatgcggcgg ctgtcagctt cagcaccttg catacagcca gcagcttcgg gaaaaacgtg 873721 atatcgtcat tcagtctctt gaacgccata cgaagtttaa agttgaaaac atggaaatca 873781 aagaaacgat tggcatggac aacccgtgga attaccgcaa taaaagccaa ttccagatcg 873841 ggcgctcgca aagcggcagc atcatcgccg gcttatacgg ccttgattct catgatatcg 873901 tgccgattaa agactgtatc gttcagcatc cggcaacgaa caaaacaaca ggcatcgtcc 873961 gccgcatttt agaggacttc aatgtgtctg tttataatga aagaaaacga aaaggcgacg 874021 ttcgcacgat cgtgacgaga gtcggctttg aaacaggcga agtgcaggtc gtgcttgtaa 874081 ccgcaaaaga aacgcttccg cacaaggaag aaatcgtcaa agcgattcaa aagcgattgc 874141 cagaggtcaa atccattatt cagaatgtaa acggggcgaa aacctcagtg atttttggtg 874201 agaaaacaaa acagctcgcc ggaaaaacag tgattcaaga agtgctcggc gacgtatctt 874261 ttgaattgag cgcccgcgct ttcttccagc tcaatccgga acagaccgtc aagctgtatg 874321 atgaagtgaa aaaagcggcg cagctgaccg gaaaagaaaa agtcgttgat gcgtattgcg 874381 gcgtcggcac tatcggcatg tgggttgcgg acggagcgaa ggaagtccgc ggcatggacg 874441 tcatcaagga atcaattgac gatgctaaga aaaacgccaa aaaacacggc atggcaaatg 874501 ccacatacgt aacaggaaca gccgagcact ggctcccgaa atggacgaaa gaaggcttcc 874561 gcccggacgt cgtcattgta gacccgccaa gaacgggctg tgacagcacg ttcttggaca 874621 cgatcaaaaa agtcaaaccg aaacgctttg tctacgtttc ctgcaatcca tccacgcttg 874681 cgaaagattt gcagacgctg tcgaaggact atcgcgtgga ctatattcag cctgtcgata 874741 tgtttccgca gacggcgcat gttgaagcag tggcgaggct tgtattaaaa tcgtctaact 874801 aaaaagaaca tttcccagtc ataaaatagt tttcctaata agacctggat ttcggtaaaa 874861 taaacaattc cgatttccgg gtctttttcg tgcgcagctc ttgtcctaac ggtctgttct 874921 caattttatc ttccttcttt tcgcggagat ctttatttta actggcgaaa agaattgaaa 874981 aaacgtgttg aaaagcaggt gaaaaaaagc gttatttaac cggaaaaata tcctcccagt 875041 atgtttaaaa tacatgagta gaatgatgta aaatcataga tgtattttca taatttgtaa 875101 aattatatat tgacttgcag ttattacgtg tgaaatattg atgataggaa tataaggaaa 875161 gtatggcgta tatcatttca agagtcattc gatgtaaaaa gttgaaacat tgtaataaat 875221 gaaagaggtg aaaatgatgg ccaaccccat tttaaaatgc ataacgtatg agcactacaa 875281 caattaaata atagtgccga gacgataaca actattacag taatacctac aatggttata 875341 tccttgcgac aatcatgctt cataatataa tgattttaga ttgacacttg gctaaaaagt 875401 attgcagaga aggaaatgga taattaaatg gataaagtat ataaaagaag ttggtttcaa 875461 acatttttgg catttttagt atctcagctt tattttaatt ttgtagaatt aacgggatgg 875521 ggtcctaagt atagagaaat gaatggattc ccagcaaaca tagttgaact agatttcttt 875581 caaacatatc tttcattcta tgataatcca tggtttaata ttattactgt tttcttggga 875641 gttttcacta ttatacaaat aattacaggg ataacaaagg atattcgaaa ttaaagcaat 875701 aacttctgat gccttattta atgatgaaag aaaatgtaca ctttcttaat tatcttatga 875761 gtgaagactg cgacacttag tcagcagtct attttatggt tctggatcag gattaccgaa 875821 ttataaccct atacaaatat atagtaggtt gccacttgct gcgttggtta ttttctaaat 875881 catgagcaaa tcccaaatga ttcagattga agttcttgaa ttcttttaaa taagggttta 875941 ttttctcttc tcatcctctt tactccatgt gattcacaag tggtagcagc ttaagtaggt 876001 tttttcattc tcttgagtac tcagttatac cacccccaac tcaatttgct ttatctctat 876061 tagtttttcc gcaaatatga tatagagata cggatatggt gtagtgttaa atatcttatc 876121 ttcaataaca gggcaattat tttgcgttgg taatatggag aactcatatg atattctatt 876181 taggttggaa tcctttttat ccaaaaagtt caaaagcaag gccactaaga aagacgaagg 876241 tcagcgccag ttaaccagaa tataaaaaat agggtagata atcatcccac gtgaaatctt 876301 caaaatttac tatagattga taagaaatgc tttcgcatgc gataagtgta aaagaagcat 876361 ggtcagtttt taatttggga taaaggttca gccgtatccc ataatgaaag gatttgattt 876421 ttgttatgac agaaaatttc tggcgtgaat taccacggcc gttttttgta ctggcaccaa 876481 tggaagatgt gacagatgtt gttttccggc atgtagtaag tgaagcaggc agaccggatg 876541 tgttttttac agagttcaca aactcagaga gctattgcca cccggatggg aaggatagcg 876601 tgcgcggccg tttgactttt acagaggatg aacagccaat tgtggcccat atatggggag 876661 ataagcctga aaacttccgt aaaatgagta ttggcatggc agagttagga tttaaaggac 876721 tagatatcaa tatgggctgc cctgtgccta atgtggcggg gaatggaaag ggaagcggcc 876781 ttatttgccg tcctgcagtt gcggcagaat taatacaagc tgcaaaagca gggggattgc 876841 ctgtaagcgt gaagacaaga cttggataca cggatgtgga tgaatggcgc gagtggctga 876901 cacacatttt gaaacaggat attgcgaatc tttctattca tctgcgtaca agggcagaaa 876961 tgagcaaagt agatgcgcat tgggagctca tcccagagat taagaaactt cgtgacgagg 877021 tggcaccaga tacattgcta acaataaacg gggatattcc tgaccgtcaa actggcttga 877081 aacttgctga acaatacggc gtcgatggaa ttatgatagg gcgcggtatt tttacaaatc 877141 ctttcgcttt tgaaaaggag ccgaaagagc atagcagcaa ggaattgctt gatctcttaa 877201 ggctgcatct ggatctccat gatgaatatt caaaagaaga agcccgtcca tacaagcctc 877261 ttcctcgctt tttcaagatt tatctccgcg gattccgagg ggcaagtgaa ttaagaaatc 877321 aatgcatgaa cacaaagtca acagatgaag tgcgtgcatt gctcgacgac tttgagagaa 877381 agtatcttga tgggatagag taacagcagt gcttgattca aaaaaggcta acaaaataaa 877441 gggattttta cacaattctt gactaaaata aacctggatt ttcggtaaat ccgggtcttt 877501 tttgtacgca gcttttactc agcctgtctt ttctctaatt tattgtaaga aaataatggt 877561 atatttagtg gagatatcat ataaaggggg agaggaaaat gaaacggcta tgcatcatcc 877621 cctgcggcaa gaaaaaaatc tgggatgtcc agcctgatgc cgggccggta agagcagagg 877681 acgcttatct cagcccgttt catcaggcgt gcgagcggta tgcaaaaaca tttttcgatg 877741 agtgggtgat tttgtcggcg aagcacgggt tcctccgccc tgatgatctc gtttcgggaa 877801 attacgatgt cacttttggc accggtcatc cggaaatcat gacagcggac gagctgcgcc 877861 gtcaatttca cgaaaaaggc ttttctgata tcgaagagct agtcatgctt ggcggaaaaa 877921 aatatcgaag cgttctaaac gccgtcatcg gagaacacca gcatatcagc tggccgctat 877981 catcatacaa aggcataggc tatatgctcc aagcgctgaa ccgggctgtt gaagaaaagc 878041 atgaactgta gcacgtacat atgaggaaaa gagtgggaac atgaaaaaac ttgtgtttgg 878101 cttgcttgcc attgtgttat tcggatgcgg actatatatc tatcatgtat ggttcggtga 878161 tccattttcg aaaaatgctg cagaacagaa gctagtgtct tatgtgaaac aaacctatcc 878221 taagaaagaa atcaagatca cgaatggggt atataacgct aaaacgtctg aatatgtatt 878281 tgaagcaacc tcccaatctc atcgctaccc aatgtgtacg aagggatttc tgcatcctaa 878341 agtaacgtgc gatggaattg aagaagcgta taccgaatca gtagcaaaac atgtaaatga 878401 agaagcaacg aaggcaatcg aagcagatct gaaaaaagcg gttcctcgat ttataaaagc 878461 tgatgctgct ttgagtatcg aaaacggaca gttcacgtta gatacaaaat ggaacaaaaa 878521 gctggctgaa aaagcgccta tgagcatgac gattcagtta gacgccagcg ggttatcaaa 878581 aacagatgcc gcaaagatgg cggaaacggt cagaaaaacg cttaatgaaa agggatatac 878641 atactcaaac ggcacgatag actgtatgca gaaggacggg gacggcggta ttggatatgt 878701 caaatattca attgattttc tttcaaaagc agctattcag tcaaacgatg cagaggaact 878761 aggaagttaa aaagatttcc aaggaaataa atacgtcgat cattgtcaaa ggccgggtga 878821 tatccggtct tttttttgca tgctgtaaaa cgagacaaat gaatcagttt gagacaaaac 878881 gagacacacg tctcaaactg tctccaaagt gaagatgaga agactgattt tacgggctca 878941 aaagactggc acacttcttg catttataat ggtgaaccct aaatagaagg aggcgcacaa 879001 aatgaaattg ttaaaacgag aaggcttgtc attaactgag gaaaaagcgc tgtggatgta 879061 ccaaaagatg ctggagatca ggggctttga agacaaagtg catgaactgt tcgcccaggg 879121 agtgcttccc ggattcgttc atttatatgc cggtgaggaa gccgtggctg taggggtgtg 879181 cgctcattta catgatggcg acagcattac aagcacccac aggggacatg gacattgtat 879241 cgccaaaggc tgtgacctgg acggcatgat ggcggaaatt ttcgggaaag cgaccggatt 879301 gtgcaaaggc aagggcggtt ctatgcacat tgcggatctt gataaaggca tgttaggcgc 879361 aaatggaatc gtcgggggcg gctttacgct cgcatgcgga tcagcgctca cggctaaata 879421 taaacagact aaaaatgtaa gcgtttgctt tttcggggac ggggcaaata accaaggtac 879481 cttccacgaa gggctgaatt tagcggctgt atggaacctt cctgtcgtat ttgttgctga 879541 aaacaacggc tatggcgaag ctaccccatt tgagtacgca tcagcctgtg attcaatcgc 879601 cgatcgggcg gctgcttata acatgccggg ggttacagtt gacggcaaag atattttagc 879661 agtttaccag gcagccgagg aagcgataga aagagcaaga aacggcggcg gcccgtcttt 879721 gattgaatgt atgacctaca gaaactacgg ccatttcgaa ggagatgccc aaacctataa 879781 aacgaaggat gaaagagttg agcaccttga agaaaaagat gccattcaag gttttaaaaa 879841 ctacctttta aaagaaacag atgctaataa gctgtcagac attgaacagc gtgtcagcga 879901 atcgattgaa aaagccgtct cgttcagcga agacagccca tatccaaaag attcggagct 879961 gctgacagat gtgtatgtgt catatgaaaa aggaggaatg taagagatgg cgagagtcat 880021 aagcatgtca gacgcgatca atgaagcaat gaagcttgcg atgagaaaag acgaaaatgt 880081 gcttttgatc ggtgaggatg tcgccggggg agcggcggtc gatcatttgc aggatgatga 880141 agcatggggc ggtgtattag gggtcacaaa gggactcgta caggaattcg ggcgtacaag 880201 agtgctggac actccgattt ctgaggcagg ctatatggga gcggctatgg ctgcggcatc 880261 aaccggtttg agaccgattg ccgagctgat gtttaacgat tttatcggca cgtgctttga 880321 tcaggtgatc aaccaagggg cgaaattccg ttatatgttc ggcggaaaag cgcaagtgcc 880381 gattaccgtc cgcaccacat acggagcagg gttccgggcc gctgcccagc attcacaatc 880441 gctgtatggc cttttcacga gcatccctgg actgaagaca gttgttccat ccaatccgta 880501 tgatgccaaa ggtcttttgc ttgcagcaat agaagataat gatccggtgt ttttctttga 880561 agacaaaacg tcctacaaca tgaagggcga ggtgccggaa gattattata caattcccct 880621 cggaaaagcg gatatcaaac gcgaaggcaa tgatgttacg ctctttgcag tcggcaagca 880681 ggtcaatact gcgcttgaag cggctgcaca gctttcagag aggggcatcg aagccgaggt 880741 ccttgatccc cgcagtctgt ctcctctgga tgaggatgcg attttcacat cgttagaaaa 880801 aacaaaccgg ctgatcatca ttgatgaagc caatccgcga tgcagcattg ccacggatat 880861 tgctgcgctt gtcgctgaca agggctttga tttgcttgat gcgccgatta aacggattac 880921 agcgccgcat acaccggttc cgttttcacc agtgcttgaa gatcaatatt tgccgacacc 880981 agataaaatt gtcagcgtca cgcttgaatt gcttggcgag ccggcattga attaaagggg 881041 ggacacaaat ggcggtaaaa gtagtgatgc caaaattggg aatggccatg aaacaagggg 881101 aagtatcgat atggaataaa aaagtaggcg acccggttga aaagggagaa agcattgcca 881161 gcattcaatc ggagaaaatt gaaatggaga tcgaagcgcc tgaaaaagga acgctgatcg 881221 atatcaaagt gaaagaggga gaagaggttc cgcccggcac agctatctgc tatatcgggg 881281 acgccaatga gtcggtgcag gaagaggcgg gggcgcctgt tgctgaagac aatatgccgc 881341 aagccgtcca gcccgtcaaa caagaaaaca aacccgcagc ctccaaaaaa gatcgaatga 881401 aaatatctcc agtcgccagg aaaatagcag aaaaagcagg attagaccta aaacaactga 881461 aaggaactgg accaggcgga cgaatcgtga aggatgacgt aacaaaggct cttgctgaac 881521 agaaaaaaga tcaagcaaag cctgtttcgg agcagaaagc gcaggaaatc ccggtgacag 881581 gcatgagaaa ggtcatcgct gcccgaatgc aggaaagcct ggcaaacagc gcgcagctga 881641 cgatcacgat gaaagctgat atcaccaagc ttgccactct tcaaaaacag ctttcaccaa 881701 ctgcggaaga gagatacggc acaaaactga cgatcactca ttttgtctca agagccgccg 881761 ttctcgctct gcaagctcac cctgtgctga acagctttta tcaaaatgag cgcatcatca 881821 cacatcccca tgtgcacctt ggtatggctg tagccttgga aaatggctta gtggtgcctg 881881 tcatccgcca tgctgaaaag ctatcgctga ttgaactggc tcaatccatc tcagaaaatg 881941 ccaaaaaagc acgcgaggga cgtgcgggaa gcgaagaact gcaaggatct actttctcca 882001 ttacaaacct tggcgcgttt ggagttgagc atttcacacc gatactaaat ccgccggaaa 882061 caggcattct cggcatcgga gcaagctatg acacaccggt gtatcaaggg gaggagatcg 882121 tcagaagcac gatcctgcca ctcagcctga catttgatca cagagcgtgt gacggcgccc 882181 ctgccgctgc attcctgaag gcgatgaaaa catatttgga agaacccgca gcattaattt 882241 tataggaaaa gcaggtgaaa acgacatgac attagccatt atcggcggcg gacctgcagg 882301 ctatgcggct gcggtttccg cggcacagca gggcagaaac gtgctgctca ttgacaaagg 882361 caagcttggg gggacctgcc tgaatgaagg ctgcatcccg acaaagtctt tgttagaaag 882421 cgcaaacgtt cttgataaaa tcaagcatgc cgacagcttt ggaatcgaac ttccggcagg 882481 tgcgatatca gtcgattgga gtaaaatgca aagccgaaaa caacaggttg tcagtcagct 882541 tgtccaaggc gttcagtacc taatgaagaa aaatcaaata caggttgtaa agggaacagc 882601 ctcctttctt tctgaaagaa agctcttgat cgaaggagaa aacggaaaag aaatcagaga 882661 ggcggaccaa gtattgattg cctccgggtc agagccaatc gagctgcctt ttgccccatt 882721 tgacggcgaa tggatcctcg acagcaaaga cgcgctttct ctttccgaga ttccgtcttc 882781 actagtcatt gtcggcggcg gtgtcatcgg gtgtgagtat gcagggctgt tcgccagatt 882841 gggatcgcag gtgaccatca ttgaaacagc ggaccggctg atcccggctg aagatgaaga 882901 tattgcccgt ctctttcagg agaaacttga ggaagacggt gtcgaagtgc atacttcatc 882961 cagattaggg cgggtggatc aaacggccaa aacggcaata tggaaaagcg gtcagcgaga 883021 gtttaaaacg aaggccgatt atgtgctggt ggcgatcggc agaaaacccc gtcttgacgg 883081 attgcagctg gaacaggccg gagttgattt ttctccaaag ggcattccgg tgaatgggca 883141 catgcagacg aacgtgcctc atatttacgc gtgcggagat gctatagggg gcattcagct 883201 cgcgcatgcc gctttccatg agggcatcat cgctgcttct catgcttccg gaagggatgt 883261 caaaatcaat gagaaacatg tgccgcgctg catctatacg tccccggaaa tcgcgtgtat 883321 cggaatgaca gaacgacagg caagaagcat atacggggat gtgaagatcg gcgaattttc 883381 attttccgca aacggcaagg cgctcattaa acagcaagcg gaaggaaagg tcaaaatcat 883441 ggctgaaccg gaattcggcg aaatcgtggg tgtctcgatg attggcccgg atgtaaccga 883501 gctcatcggc caagcggcag cgatcatgaa tggtgagatg acggcagata tggcggagca 883561 ttttatcgcc gcccatccga ctttatcgga aacattgcat gaggcgctgt taagcacgat 883621 cggccttgcg gtacatgcat aataaaggaa aaagcaggcg catggatata aggcgcctgc 883681 ttttttattg ttgaaagcgc tttatttttc ccctacaata gatgaaaacg gcgtgtaagg 883741 gaggagcgat caaggaaatg aattcggtcc caaacgattt gcaaacctgg aaacgttttg 883801 tgaaagacgg tgtgcttgac gaagcccgat taagaaaacg gattgcagag tcatggcatc 883861 gctgcaaaaa agctgaggtc aatccttatt tagaaaaagg cccgaaggtt ttacagcaaa 883921 cggagctgga tcagcagtca aaaaaacatt cattcttctt gacgaccgca aagccttacc 883981 tcgaaaaact gctgcctgcc ataaaagaaa tggaaatgat ggcgctgtta attgattcag 884041 acggtgttgt tctggcattg gacggccatc cgcgcgcgct ctatgaagcc aaacgcatca 884101 atttcgtcga aggggcatgc tggacagaaa cggctgtcgg aacaaatgcg attggcacgg 884161 cgctccacat cagcgagccg gttgcaatac aaggatcaga gcattactct atcgcttccc 884221 atctttggaa ctgttcagct gctccgattc accatgagga tggcagcctt gcgggtgtaa 884281 ttgacatatc atgcccggcg gcaggcgcgc atcctcatat gcttggtatt gccacggcga 884341 ttgcctatgc cgctgaacgg gaactcgcag ctaaaagccg tgagaaagag ctggagctga 884401 tcagccgttt tggggagaga gctgcatcca gtgtgccgat ggtgctctgt aataccaagc 884461 agcacatcat cagtgcgagc atgccgattc gaacctcaat gccggattgg cagggccggc 884521 acctgtacga gttgaaggaa cggggctatt caatcgaaaa tgctgtcacc ataggagatg 884581 gcggcacttg tttttatctt tcggaacaaa agaaaaagaa ggcgtttcga ttcaatggag 884641 tgatcgggca aagcggccga tcgcaagcga tgctgatgca ccttgaacga gcagctgcga 884701 cggatgcatc ggtctgtttg tcgggtgaaa cgggtacggg gaaggaggtc gcggctcgcg 884761 cgcttcatga gaacagtgag agacggcacg gtccgtttgt tgctgtcaat tgcggagcga 884821 ttccgtctga tttgattgaa agcgaactgt tcggatatgc agagggcgct tttacgggag 884881 cgaaacgaaa tggctataaa ggcgcctttc aaaaagcgaa tcaaggcaca ttatttttag 884941 atgaaatcgg agaaatttcc cactcgatgc aggttgcact tttacgggtg cttcaggaac 885001 gcaagataac gccaatcggc gggacgaaag aaattccggt tgatatcaga gttattgccg 885061 ccacacattg tgatttacgc gagcttgccg aaaacggaaa aatcagagag gacttgtttt 885121 accgtcttca tgtctatcca attgaactcc ctccattacg cgatcgcacc gaggatatcc 885181 cggatctctt tgagtactac aaacagaaga atcattggcc aggcgatctt ccttctgatt 885241 tttgtaatgt gctgaagcaa tggaagtggc cggggaatat ccgcgagctg tttaatgtgt 885301 ttgaacgtct ttctatcaga tttccggacg gccggctgag agatgaatcg cttcccgctt 885361 tactggaagc cgctggattg ccggccagct ctgcagaaaa aaagccggct gctgccggcg 885421 tgcttacttt tcgtgagcaa atccaaaagg atatgatgat caaagcgctt gaatctgcaa 885481 aaggaaacgt ctctcaagcc gcaaaaatca gcgggatccc ccgaagcact ttctacaaac 885541 gcctgaaaaa attcaacttg tccgctgaat cataaagcat acttccttca ggaaatggaa 885601 acgttatgta ttgaaggagg gtgttacgat gaatattcaa agggcgaaag aaattgtaga 885661 atctcccgac atgaagaaag taacatataa cggcgttcct atttacattc agcacgtaaa 885721 tgaagaaact ggaacagcaa gaatttatcc gcttgacgaa ccgcaagagg agcatgaagt 885781 gcagctgaac agcttaaaag aggattaaac aaaaatggcc cgcttcataa gcaggccatt 885841 ttgttatccg cgcggcgcaa ataaaataac acagacaccg atgagacaaa tgaatgcgcc 885901 gatccagtca tacagatcag gtgttttccg gtcaacaagc catccccaca ggaccgcaag 885961 cacgatgaat actccgccat aagcggcgta tacacggccg aaagatggga aggactgaaa 886021 cgtcggaaga atgccgtata caatgaggat cagcgccccg gcgattccgt agccagctgg 886081 ctttgcctct ctcagccata gccaaaccag atatccgccg ccaatttcag caagccctgc 886141 cgcgagaaat aaaagaatgg taatcagcat catgagcact cctcaatttg catttatctt 886201 tcattataga ggaggagagc ttttaaagct tcggatgatt ctcaaattcc ttcaaatacg 886261 cttttcgctg aacctctgta aattggctga tccaattgtt ttgagcctct tcattcaaat 886321 ggggaaggat atagcgttca accgcttcga aaaacagcgg attcgtgatg atgttccagg 886381 tcgggattcg aacgattttg ccgtctgttt tctcgatgat aatatcctca aaaaagatcc 886441 ctttcaaact gtattgatgg cgtcccatat aaagccgctt cacctcggaa aacagcacgc 886501 tgcgctttct caagaagatt tcgccactag gtccggtctt tatggtgaaa atgacatttc 886561 cacggcttgt gaacgcagga aaagccataa agaatgtgat caatccataa atcatcgcca 886621 gtaatccgcc gcccaaataa agcagggcat atttagattc aaacgtgagg gcttcagaca 886681 ccagccagac tcccacaata aaggcgcccc ctgtagcgag gaacagccaa gcccttagaa 886741 acatcatgct ttttacttca atcatgtgct gcccctaaag cttcggatga ttctcaaatt 886801 ccttcaaata cgcactgcgt tggatgtctg taaactgtcc gatccaattg cttttcgcct 886861 cttcattcag atgtggaagg atatagcgtt caaccgcttc gaaaaacaac ggattcggaa 886921 tgatgttcca agtgggaatg cgaatggtct tctgatccac ggtttggatc aatatatctt 886981 cttggaagat tccttttaga ctaaatttat ggcggctcat ctcaattttc ttgatatcag 887041 taaacgtaac agacactttg tcagtgaaca cttctccatt ttttcctgtc ttgatgcgga 887101 aaatggtatt tccccgcggg gtgaaagccg gaaagaagat gataaataaa tataaacaaa 887161 acaaggtgaa cagaaagcca gcaggaatgg ctaataggta atatttcgtt tgaaacgtaa 887221 tacccatata aaagagccac aaacatgcta atcccatacc ggcagatccg acaaaagccc 887281 atattctcag gaacattttg cttttgactt caatgatttc ttggtttttc aatgcttttc 887341 tccttttgtt aattcaattc ttatcatttt gaaatgattt gatttacaac atccttatga 887401 gcagggagga tagaaaattc attctgggtg atgcctgtga caagccaagt atggtgggcc 887461 cccggcagga cgaatgccat gtcagccact tcaggagtgt tatcttttcc atatgccaga 887521 cgcataagtg tatccatttt ccctttccgc aaagccagat catttgcaaa tcgggtaacg 887581 tcctcttggt ggtcatgttt ttcaaggaac tcttttagat atgaagggtt gtctgaagcg 887641 ccctccaaga gtttttcaaa ttcatttgat gtcaatgtta caatcgattc tcttttatcc 887701 tctgtatcta ttatatgtaa aaactcatct gtcttagcaa gtaacccttc acttgattcc 887761 atttttgtaa tgcgatggac ttgttcatca aaaaggagtt cgtgagagta ggtgccgaat 887821 tttgatacat ggcatgacac attctgttcg gcaccttgcc cgttaaattt agaaagcttc 887881 actgtatagt cagcgtcgtt taatacatgg ataaacggac agtactcgtc ctttaaccga 887941 tattgatggt tccgatattc cgctgcatcc ttggctaaga gtgagcggca cgcggcttca 888001 aataaggcgc cgagctgttc atcttctatt tccggaaaat aggcctgctt caaggccatt 888061 ccctgttcaa aaaacccttc gctgtaaaag caaaacaaga gttcttctat gctaattgta 888121 aactgcttca ttgtttattc tcctatccaa atgaaaattt ccctttaagg aaatgggttg 888181 cgccgtgtat aagcgaatcc gctgttttct ttgctttttc cattcctttt ttcgcgctgt 888241 ctatcccttt atgtatcgat ttattcgccg catctatgcc gtcattcact gatttgacga 888301 ctttgccggc tgattccagc ccttttttgg ctgtatcaac aacagcatgg atcggttctt 888361 tcagctttaa ggctgctttt tcagcaaaac cggctgtata tttggcgatt tgttctccga 888421 cgactccgcc aatgtatgaa cctgctgccc caagaaggac agtacccaca ggtcctgcaa 888481 agcttccgat tgcaccgccg atgacagcac cagctgtggc accgccggca acaaaaatcg 888541 tattattcac agcattcccg acggccttgg cgttttcacg cttgagaact tccggtttat 888601 cctggtattt tgcataattt tcagcaattt tcacgcctgc tccgaatgtt tcggtcgctc 888661 cggtaatcag tgtggcggta atggcatttc ctttcgcgaa tctcaagccc gtttttccca 888721 catccttcaa agtggagcgt acgccggctt cattaagaaa tccttttgtg tagcttctga 888781 cgctgtttga aaaatccacc gtgtcctgag gaaagtattt tgtaaacttt ttatgtacca 888841 aatctgaaaa tggacggttt gtctttttca acaaatattt aggattcaaa agcactcttg 888901 ccgctttttg ataacgtgag ctgtcaacgg ccctggaaat atccaagagc agttttgagt 888961 gctgggctgt atgcaagccg cttggttgtt tcacaaattt cgtaagccct aatccgtaat 889021 attttccctg cgtcagcata agagcggtta agcttgtcat cgtaccgtat ttgtcgtagg 889081 cattgtagag ctttcgcaaa atatcatctt gttccacaaa tttatcgcct gtttttctga 889141 tgaaaatctc attgtcactc agcttagtga cgagcgcctt tcctgagctc cacgcatcgc 889201 ccactccaga aaaacagctg ctgtagcggg gatcgcattg caaaatcatc tgccccagct 889261 ccacatgcag gtccttatat ttgttttcca tatcagttaa ttcagtgact acatcatttg 889321 caagctgttc gagcttatcc ggatcaactg caatgtttcc tgacacaccg ttcacctccc 889381 gagtttatgt ctttcctctc ttgctttacg ctccagttct tccattctgg caatttcagc 889441 ttttcgttct tctattttga cagcggcagc cttcagctct tggcttgttt caagcagctc 889501 ctgttcgaat tgatcgtagg cggctttcgt ttcctcgaaa tcctggtcaa acgaatctct 889561 tgctttgccc tgccaagcat ctcccaatgc agataaccgg gattcaagca gcattttgga 889621 gcttctgacc tcttctgcgg ccgcactata cttgtttgcc agctcaatga ctttatatga 889681 gtccaacttt tgtcccctgc cttttctaaa ttcacgcaca attggatgtt ttatataaat 889741 gattataaat aattcggcat gtatccgaat cgtacaaaag aaccttttca taagaattgg 889801 aagggcgtat attcacttaa aattcacagt tggtgagact ttaagattac aaaaaaggta 889861 aaaaaaccaa atctctcaga cataaggcaa atgagaaatt tcccgctcta tgggaaaaaa 889921 cactaaagtt gatcaaatga cctaagtgcg ccaaacgtgt tacgggacga gctatctcat 889981 ggtataaatg gaattgtaaa cgttatcaag gaggtcgtca tatgaagaaa aaatcattct 890041 caatcgtaat agcgggcgga gggagcactt tcactccagg gatcgtactc atgctcttgg 890101 accatttgga ggagtttccg atcagaaagc tgaagctgta tgataatgat aaggagagac 890161 aggatcgaat tgcaggcgcc tgtgacgttt ttatcagaga aaaagcgccg gatattgaat 890221 ttgcagcgac gactgacccg gaagaagctt ttacagatgt cgattttgtt atggcgcaca 890281 tcagagtagg gaaatacgcg atgcgcgcgc ttgatgagca aattccgtta aagtacggag 890341 ttgtcggcca ggagacgtgc gggccgggcg ggatcgcata cggtatgcgt tcgatcggcg 890401 gtgtgcttga aatattagat tacatggaaa aatactcgcc tgatgcgtgg atgctcaatt 890461 attccaatcc ggcggcaatt gtggctgaag ctacgagacg ccttagaccg aattctaaaa 890521 ttctcaatat ctgtgatatg ccggttggga tcgaagaccg gatggcgcaa attcttggct 890581 tatcctcaag aaaagaaatg aaggtccgct attacggatt gaatcatttc ggctggtgga 890641 catcgattca ggatcaagag ggcaacgatt taatgccgaa gctgaaggaa catgtatccc 890701 aatacggtta tattccgaaa acagaggctg aagctgtgga ggcaagctgg aatgacacgt 890761 tcgccaaagc gcgtgacgtg caggctgcag atcctgacac actgccgaat acgtatttgc 890821 aatattattt gttcccagat gatatggtga aaaaatcaaa tccgaatcat acgcgggcga 890881 atgaagtcat ggaagggcgc gaagctttta ttttcagcca atgtgacatg atcacacgtg 890941 aacagtcctc ggaaaacagc gaaattaaaa tcgatgacca cgcatcgtat atcgttgatc 891001 ttgcccgggc gattgcctac aacacaggtg aaagaatgct gttgattgtt gaaaataacg 891061 gtgcaattgc gaactttgac ccgactgcga tggttgaggt gccatgcatc gtcggctcaa 891121 atggacctga accgattacc gttggcacca ttccgcaatt ccagaaaggg ctcatggagc 891181 agcaggtatc cgttgagaag ctgactgttg aagcgtgggc agagaaatcg ttccaaaagc 891241 tgtggcaggc gctgatcctg tcaaaaacag tgccgaacgc gcgtgtggca agactcattc 891301 ttgaggattt agtggaggcc aacaaagact tctggcctga gcttgatcaa agcccaaccc 891361 gcatatcata aatgaaattc ccccattttc gaatctgtaa ttgtatataa tagaaagaaa 891421 atggggggat ctgatatgca gctcgaagaa ctgatcaatc agcactacag caaattgaat 891481 gacaacgatt ttcatatttt aaaatatata ttgaatcata agcacacatg ctatcacctt 891541 ggaatcgacg cgctggccaa agcttgcagt gtatcgcgtt cctcaatttt acggcttgcc 891601 caaaagctcg gtttcagcgg ttacagtgaa tttcgcgtct ttttaaagtg ggaagatcag 891661 ccggaagaag gcgagagtat gagttttgaa aagctgcttg atgatattga agcaaatttg 891721 aagtttttac ggacaaagga catgacggac atgtgccagc tgattgatgc agctgaccgc 891781 attttcgtct acggttctgg aaatgcgcaa aagatatgcg cccgcgacct gcaaagaatg 891841 tttattccgc gccatcgcta tcttattttg attgaagaca caaatgaatt taatttgatg 891901 cgcgatgatt ttaaagtgaa cgatctgttt atcatcattt ctctttccgg agaaacaccg 891961 gagctgattc ctcaggcaag aatgctttct gcaaagggta ttccctttat ttccattacg 892021 aatttaaaaa acaatgtcct cgcccagctg actccgcata atctttatgc gacaagcaaa 892081 cctgtgacat taagcgatag aacggaaatt gtcgcttttg caccgttttt tctcgttggc 892141 gaagcattgt tccgcgcata tgttgattac aaagaggcag aaaaaaatga caatgagtag 892201 cagggggttc tggtatgatg caaaaaattc agcgctttgg aagcgcgatg tttgtgcctg 892261 ttttattatt cgcgttcgcc ggcattatcg tcggtatcag cacgctcttt aaaaataaaa 892321 ccctcatggg accgctcgcc gatcctgacg gtttttggta tcagtgctgg tatatcattg 892381 agcagggcgg ctggactgtt tttaaccaaa tgccgctctt attcgccatt ggcatcccgg 892441 ttgctttggc gaagaaagct caggcacgcg cctgtttgga agcgcttact gtctacctga 892501 cattcaacta ttttgtcagc gcgatattga cggtatgggg aggagcattt ggcgtcgaca 892561 tgaatcaaga ggtcggcgga acgagcgggt taacgatgat tgcgggcata aaaacgctcg 892621 ataccaacat catcggagcc atctttattt cttcgattgt cgtctttttg cataatcgct 892681 attttgataa aaaactgccc gattttctcg gcatctttca aggctcaaca tatatcgtga 892741 tgatttcctt ctttattatg atcccaattg cgttggctgt gtcttatatt tggccgatgg 892801 ttcaatcggg aatcggctcg cttcaaagct tcctggttgc ttctggggcg gtgggcgttt 892861 ggatatacac gtttttggaa cggattttaa ttccgaccgg ccttcatcac tttatttaca 892921 cgccgtttat ttatggcccg gctgtagcgg aaggcgggat cgtcacgtat tgggcacagc 892981 atctcggcga atattcgcaa agcgccaaac cgctgaagga gctctttccg caaggcggat 893041 tcgcgcttca cggcaactcg aaaatcttcg gtattccggg tatcgccctg gctttttatg 893101 tgacagccaa aaaggaaaag aaaaaactcg tcgcagggct gctgattcct gtcacactga 893161 cagcgattgt cgccggtatt acagagccga ttgagtttac gttcttattc atttcacctt 893221 tcttatttgc ggttcacgcc gtgcttgccg ccacaatgtc gacagttatg tatatggccg 893281 gcgtcgtcgg aaatatggga ggcggactga ttgaggcggt aaccttgaac tggattccgc 893341 tctttggcag ccacggtatg acatatgtgt atcaaatttt gatcgggctc tcgtttacag 893401 caatttattt tttcgtcttc agatttttaa tcctcaaatt caatatcgct acaccaggac 893461 gggaaaagga tgaacagcag gaaacaaagc tatattcgaa aaaggaatac agagaacgaa 893521 aaaacaagga tgaaacggcc tccgctgctg aaacggctga tgacaccgct tttctgtata 893581 ttgaagcgct gggcggaaaa gacaacatca ctgaagtcac aaactgcgcc acccgcctca 893641 gagtcagtgt caaggatgaa acaaaggttg aacccgacag cgtattccgc gcgcttggcg 893701 cacacggcgt tgtcaggaac gggaaggcgt ttcaggtaat tatcggatta agcgtgccgc 893761 agatgcggga gcgtgtggaa aaaatattga atcaataaag actgccctcc ttttcgggag 893821 ggttttcgtt tgccgtcaaa aagaccgcca tagtaaagta aagaaagaga caatcgagta 893881 aaaaggggtt tggaggcttt tacatgcaaa aggctttgtc gtttttaaaa ccatattcat 893941 tgctggcggg aattgctctg attcttatgc tgacggagct tgcagttgaa ctgatgcagc 894001 ctttattgat tgcaaaaatc atcgacgatg ggatattgaa gcaagatctg cggcatgtat 894061 ggatatgggg cacggtcatg atcgggctga ccgtgttatc ctttgcggcg gggatgctga 894121 attcctttta tgccgcccat gtcagccaaa gcttttccta tgatacgaga aaagggcttt 894181 ttcaaaaaat ccagtccttc tcctattcca catttggaca gttttcgtcc tcttcttata 894241 ttacaaggct gacaaacgac gtcacacagg ttcaaaatat gatttttatg agtttgcggt 894301 ttatgctgcg ggctccctta atgattgcag gcggcattgt gctgtcgctt gccgttaatg 894361 tgaaactcgg gttttttctg cttgtgacca ttccgatcct gatcttgttt ttgctatggg 894421 tattaaggaa aggcggggca ctgttccgct cagtgcagaa aaggctggat caagtgaaca 894481 ccatcatgca ggaaaattta attgcaatca agctgatcaa agcgctgctt cgcggcagcc 894541 acgaagtcaa acgatttatc aaagccaaca caaggctgat ggaaaaaacg gtttcggcct 894601 ttcagcttgt ggaattcacg atgcctgtac tgatgctgct gatgaatctc tgcatccttt 894661 tgattttgtg ggcggggtcc tacagtatta cgagcggaag cactcaggtt ggcgatgttg 894721 ttgcgataat taactacgca acacgaatta caggcgcgct ttcgatgttt ccgtttttga 894781 ttatgatttt cacccgggcg aaggcttcag gggatagaat cggtgaggtg cttgaaacag 894841 aaggcgacga gcgggaggaa ggcaccatat ctgatcgttt gtcaggacgg attgagtttc 894901 agcatgtatc ctttcgctat cctgaaatgg acagagaagc gctcaggaat gtctcatttt 894961 ccgcaaagcc aagagaaacg atcgcgattc tcggtgcgac gggctcgggc aagtccacgc 895021 tttttcagct cattccgcgg ctttatcagc cggattcagg ccgcatttac atagatgaaa 895081 agccggttca agatattccg gctgaagggc tgcgcaggca aattggatat gtaccgcagg 895141 aagtcctctt gttttccggc acaatcaaag aaaacatcgc ttggggcaaa gaaaatgctt 895201 cactagatga aataatggat gcggcaaaac ttgcgcaaat tcatgaaacg attttaaagc 895261 tcccaaatgg atatgacact gttttggggc aaagaggcgt caacctgtcc ggcggccaaa 895321 agcagcggat ttccattgcg cgggcgctga ttcgaaaacc ggctatcctt ctattagatg 895381 acagcacaag cgcgcttgat ctgcaaacgg aggcgaagct gcttgaagca atcagcacat 895441 accattgcac aactttgatc attacacaaa aaataaccac ggcgatgaaa gctgatcaga 895501 ttttgctgct tgaggacggc gaactgattg aaaaaggcac tcacagtgag ctgctttctg 895561 aatctcagtt atacaagcgc atttacgagt cacaattcgg aagggagggg agcgagtcat 895621 gctaaaagac atccgcaagc ctttccaata tcccaaactg ccaattgaca aaaaagaagg 895681 cgcgaaaaag cgggcgaaag caaaggatac aaagggcaca ctgagacgaa tctggtctta 895741 cttggctgaa agaaaaggac tgctcatact tgtcatgcta atggttgtca tcagcgccat 895801 attcggactc cttggtccct ttgtgatcgg aaaggccatc gaccatttta tcgtcgggaa 895861 aacggtcagc ggcttgattc ctgttttgct tcttctgctc gctatctata tcattcagtc 895921 cctgtcgctt tggtttcaaa actattggat gattacgatc tcgcagggca cggttttcag 895981 aatgagaagc gaattgttca cccatctgca tgagctgccg attccatttt ttgataaaca 896041 gcggcacggc gagctgatga gccgggtgac gaatgacatc gaaaatgtca gttctacctt 896101 aaacacgtca gtcattcaaa ttttgtcaag tgtgatcacc tttgtcggga cgattgcggt 896161 gatgctgtac atgagcccgc tccttacttt gattacgctg accattattc cggtgatggc 896221 agcgagcctg aaatggatca ccaaccgaac gggaaagctg tttaaagaac agcagaaaaa 896281 ccttggtgat ctgaatgggt atattgagga atctgtttca ggcgcaaagg tcatcaaagc 896341 atattcacgt gagaagcaga ttactgctga attcctcgaa aaaaacgctg cactcaagac 896401 gtcgggcttt tgggcgcaga cgatttccgg gtttattccg aaggtcatga actctttgaa 896461 taacttaagc tttacaatga ttgcggcaat cggcggtttg tttgcgctga aaggctggat 896521 ctcgatcggc tccatcgttg tctttgccga gtattcaaga caatttacac gccctttaaa 896581 cgatctggcc aaccagttta atacgatgct gtccgcaatc gccggcgctg aacgggtgtt 896641 tgacgtgctt gatgaaaaag aagagcgcga ggatgaaaag aacgccgtgc atcagcccat 896701 ccaaacaggc agcattgaat tccgggatgt gtccttcggt tacgataaag ggcagcagac 896761 actgaagcat ttacagttta ccgtgcctgc ggggcagtcc atcgcgtttg taggaccgac 896821 gggggcgggg aagacaaccg tcactaacct tctcgcccgt ttttacgagc ctaacgatgg 896881 aaaaatttta atcgatggta cagatattaa aacccttact agagcaagcc taagaaaaaa 896941 catggggttt gttcttcagg attctttctt atttcaggga acgatcagag aaaacattcg 897001 ctacggcagg cttgatgctt ctgatcagga agtcgaagcc gctgcaaaaa cagcgaatgc 897061 ccatagtttt attgaaaggc tgccaaaagg gtatgacacc gtactgacgc aaaacggttc 897121 gggcatcagt caagggcaga agcagttgat ttctatagcg agggcggtgc ttgccgatcc 897181 ggttcttctc attttggatg aagcgacaag caacattgat accgttacag aagtcaacat 897241 tcaagaagcg ctcgcccgtt taatggaagg aagaacaagc gtcatcattg cccacaggct 897301 gaacaccatt caaagagcgg accagattgt ggtgctaaaa aacggtgaaa tgattgaaaa 897361 aggcagccat gacgagctga ttcggcaaaa aggattttac agtgacttat atgaaagcca 897421 atttgagaaa tagacctttg tcctgcacag aggtcttttt ttgttacagt tttatagtac 897481 ttttatttca ttttcgtaaa atgtaacaaa attacttgac gtaaacaagt tatgtatata 897541 tactagctta cattaagtaa gtgataacat ttatcaagga ggataaaatg aataaatcat 897601 ttgaaattgg cacattactt ttaagagtta ttacaggtat tatctttttt gttcacggtt 897661 tatcaaagtt tcagggaatg gagggcacca tccaattttt cggcagcata ggccttccaa 897721 gctttatggc gtatgtcatc gcagcgattg aactgattgg cggagtgctt gtcttcttcg 897781 gattggctac acgtattgtc ggtgtactgt tcgctcttac actgatcggc gccatcatca 897841 ctgttaagct gaaagcgcca ttcatgggca atgcagaatt tgattacctt ctgcttttga 897901 catccattca cctggcgctt actggaagtc gattcctggc gctggaccca tttgtgttta 897961 aaggaaaaaa gaacggaaac gtttcagcat aagaaaagag gcatgcagca tgaccagcat 898021 tcatgaggat acacacattg gctatgccaa actcacaatt cgcagtctgg agcgttcgct 898081 tcagttctac tgtaacgtca tcggttttca agtcttaaaa aagacggacc gccaagcgga 898141 attaacggct gacgggaaac gcgtactgct tattcttgaa gaaaatccga gcgctgtcgt 898201 cttgcctgaa cggtctgtga caggccttta tcactttgcg attcttcttc cggacaggaa 898261 agaacttggg atcgcgctcg cccgcctgat tgaacacggc attgctatcg gacatggaga 898321 ccatgctgtc agcgaagcgc tctacctgtc tgatcctgac ggaaacggca ttgaaatgta 898381 cgctgaccgc ccccgcagca cgtggcagcg tgatcgggaa ggaaactacg tcatgacgac 898441 aaccgctgtt gacattgagg gccttctgga agaggcagga gatgagcgga aaacatcgct 898501 tccgaacgat acaatcatcg gacacattca tctgcatgtc agtgatttga aagaagcaaa 898561 ggcgttttat acagatgtac tgggctttga cattgtcgga aactatgcgg gcatgtccgc 898621 cctcttcgtt tcagccgggg ggtaccacca tcatatcggc ttaaacattt gggcgggaag 898681 aaatgcgccg cctaaaccga caaatgccag cggactagat tattatactg ttgtcctgcc 898741 ccaccaagag gagctggatt tggtggcaaa ccgagtcaaa catgccgggt attcgattga 898801 agagacggaa aacagctttc gtgtgaaaga ccctgtttcc ggcgcctata ttacatttgt 898861 gatttaactg caatcccctt gccgaaataa cggcaggggg attttttatt tttgtccgcc 898921 ttgttatgat gagagaacca acttgttagg aggcgtttac atggaactca accaccttgt 898981 gacgggcaaa atagcattaa atcaatatgt gcatcgctta gagcaaaagg atgtttcatt 899041 ttacgtccac tactggggag cgatgacgaa ccactataac acactgcttc ataagcattc 899101 cttttatgaa atttgttacg tggtaagagg tgaaggatat taccttgaag gcgatcgtac 899161 atatccgctt cgtgaacaga cgattttttt gtcaaagccg gagcatttgc accaaatcaa 899221 aagtgaaaca gggctgttcc ttttttacgt cgctttcgag ctgagcgagg atcagtcaag 899281 cgccgaatgg atcaaagtga tggaagaagt gaaacaaagc ccctttatca caatgcaatt 899341 gaaagatggc gaaccgccgg gcctgctttg gaaaacgtta atgctgcaag cagcgcaacc 899401 tgtcaatgct tttgacaaag agatcctatc tcatttgtcg catgcattga tcctgtcatt 899461 aatccaaacc tttctcccgt acgcccaacg cccgaaacaa aagcagccca ttcacacatc 899521 ttctgctttg ctgacagagg tgaaactgca cataaaagac aatctgtcac agccgttaaa 899581 gctgacggat gtcgctagcc actttcatat ctcagggagg catttatcac gtttatttgc 899641 agcagaactg ggcgtcagct actcagaatt tgtccaaaat gaaaaaataa acaaagctgc 899701 cgaactgctg aaatcaacga atttgtcgat taaagaaata gcggaagaaa tcggtttctc 899761 agtacattat ttcactcgcg tcttttccgc taaaatcggc agctctccag ggcttttccg 899821 ctccctttat aaagactcaa aaatgaccgc atttcaaatc aataaacctt ttcaaaaaat 899881 cgaacaggcc aagccgcacg aataagatgt cctgaaatga caaaacaatg tcttcatatg 899941 ataaagacgc gagaaatctc gttgtcttat aatcttttta gaaagcggtt acaacaaggg 900001 gtattgctga aggagggatg cattggctta tgcttggtgt cgggtgctct gccattcttg 900061 aaagaagggg aagaaagccg tgagtacaaa aaagaaagag gctgtaatag gaaaagaaag 900121 cttagctcat aaagggcttt tacgaacgat tacattggta tctacattcg gcggcctgtt 900181 gttcggttat gatacgggtg tcattaatgg ggcacttcct tttatggcaa ctgcaggtca 900241 gctgaatctt acacctgtta cagaaggact ggttgcgagt tccctgcttc tcggggcagc 900301 cttcggggcg atgtttggag gacgtctgtc cgatcggcac ggccgccgaa aaacgatcct 900361 ttatttagcc ttactcttca tcgcagccac acttggctgt accttttcac caaacgcgtc 900421 cgtgatgatt gcctttcgtt ttctgcttgg actggcggtt ggctgcgctt ctgtaacggt 900481 tccaaccttt ttagcggaaa tttcgccggc agaacgcagg ggacgaatcg tgacacaaaa 900541 tgaactgatg atcgtaattg gccagcttct ggcatacacc tttaacgcca ttattggcag 900601 cacaatgggg gagagcgcaa atgtatggcg gtatatgctg gtcatcgcga cacttccggc 900661 tgttgtgtta tggttcggaa tgctcatcgt gcctgaaagc ccgcgctggc tggcagctaa 900721 aggcagaatg ggtgacgccc tgcgggtgct tcggcaaatc cgtgaagaca gtcaggcaca 900781 gcaggaaata aaagaaatca aacatgcgat tgagggcaca gcaaaaaagg ccggctttca 900841 tgattttcaa gagccgtgga taaggcgcat tctattcatt gggattggaa tcgccatcgt 900901 acagcaaatt accggtgtca attcgattat gtactatggg acagaaattc tgagagaagc 900961 cggttttcaa acagaagctg cattaatcgg caatattgca aacggtgtta tttcagttat 901021 tgcggtcatt tttgggatat ggcttctcgg caaagtccgt cgccggccca tgctgatcat 901081 cggacagatt ggcacgatga cagcccttct gctgatcggg attttatcca ttgtccttga 901141 aggaacaccc gccctgccgt atgttgtgct gagtttgacc attttgtttc ttgcgtttca 901201 gcagactgcc atttctacgg tgacgtggct gatgctctcg gaaatctttc ctatgcatgt 901261 gcgggggctt ggcatgggga tcagcacctt ctgcttgtgg acagctaact ttctcattgg 901321 attcaccttt cccattttgc tcaatcatat tgggatgtcg gcgacatttt ttatctttgt 901381 cgctatgaat atcctagcga ttctatttgt gaaaaaatat gtgcctgaga caaaagggcg 901441 gtcacttgaa cagcttgagc attcctttcg ccagtatggc cgccgcgctg atcaggaaat 901501 ccaaaatcaa acaactcact tatcgtaacc tgagatacca ggaggaatct atcaatgaaa 901561 ctatcttatg taacagacag cctagggcat ttgccttttg aagacatgct caattttgcc 901621 gcaaagcttg ggatcgatac acttgaaatg acaaccgggg gctggtcgcc ggcacctcac 901681 ttgaatcttg atgaattgct gcaaagcagc gaaaaaagaa aagaattttc acaagcgctg 901741 gaaaagcgga acatgacact ttgcgcatta aactgctcgg ggaacccttt agatccgggt 901801 gaattgggca aatcgcacag agacataact gacaaaacga tggagctggc tggattatta 901861 ggcgtcaaaa aagtgatcat gatgagcggt ttgccagccg gcggcccgga cgacaaagtg 901921 ccgaactgga tcacatacac agtaagctgg cctcccgttt taaaagatat cctcaactat 901981 caatgggaag acgttgcgat cccatattgg aagaagcttg tcaaaaaagc ggaggcctgc 902041 ggcgtgggga aaatagcgct tgagaacttc agctctcaat tagtctataa tcctgagact 902101 ctctttcggc tcagaaatgc agtcggcccg atggtcggtt tgaatcttga cccgagccat 902161 ttgttatgga tgggcgcaga cccgatcatc gcagcaaggg agctcggctc agccattcac 902221 catgtccatg ggaaagatgt cagaattgaa agatatttat cggcggtcaa cggactttta 902281 gaaacaaaag aagtgacaga tcctgcaaac cgggcgtgga attacgtagc tgtcggctgt 902341 ggacaggatt tacagtggtg gaaggaattt ttttcagttg taaaaatgat gggatatgaa 902401 ggtgaggttt ctttagaaat ggaggatctg acgatgtcac ctgaagcggg catccgtact 902461 tctgtagaag ctttaaaaca aaccatcagc caataggagg ttttcatgat gctaaatgga 902521 gaaagaatca tctctaagcc gcttcgctgg gcaatggtag gcggcgggcg gctcagccag 902581 gttggatata aacatcgtat tggagcgctg agagacaata ctgcttttca attaactgct 902641 ggcgcttttg atatcgatgc cgaaagagga aaagatttcg gggtgaacct tggagtggat 902701 gcggaacgct gttatcccaa ctatcaaacc atgtttgccg aggaagcgaa aagacaggat 902761 ggcatagagg tagtatcgat tgccactccg aacggcactc attatgagat ttgtaaggcg 902821 gcgcttgaag caggagtgca tgtcatctgt gaaaaaccgc tgttcttcac ttcagcagag 902881 gggcaggaaa tcaaagcgct cgcagagaaa aaagggaaaa ttgtcggcgt gacgtacggt 902941 ttttcaggca atcaaatgct tcttcaaatg cgtgcgatga ttgaacaagg aatgatcggc 903001 gatattcgcg tggttgactt gcagtacaca cacggttttt gtgcaacaga tgaaggtgaa 903061 aagataagcg ctgcacagaa atggcgtgtc gaccctgcga tcgccgggcc aagctttgtg 903121 ctgggcgatt tatctaccca cacgtattat atgtcacagc ttattatgcc aaagatgaaa 903181 attaaggagc tgctgtgtga ccgacagagc ttcgtcggca gccgcgcacc gctagaggat 903241 aatgcccatg tgctgatgca ttatgaaaat ggagcggtcg gaacgatgtg gacatcgtca 903301 atcaatgccg gatgtatgga tggccataga atccggattg tcggctcaaa ggcaagcatt 903361 gagtggtggg acagcaagcc aaatgaactg acgtatgaag tgcagggaga gccgggccag 903421 acactcgttc gcggcatgcc gtatttagat gatgtttgca acgccgatga acgactgggc 903481 gccttacaca gcgaagggct gtccgaagca tgggccaata tttatcttaa atttgccatt 903541 gcgatagacg ccaaaaaccg tgaagatgaa gaaatcttga acaacttggt ttatcctgac 903601 attgatgcag ggatcgaggg cattcgctgg attgagaact gcgtgcgctc ggcaaaccaa 903661 gggtcagttt gggttgaatt taaataaatg agggaatgcg ccgcatatga cataaagttc 903721 atatgcggtt tttattttcc agaaactcct gtcaaaaatg ccctgaggca ggtatgataa 903781 gaagggaatt gggtatcggg agtgatgagc gtgaaagctc ttttttttac gagaatgttc 903841 accttgatgg tgagctgttt aatgtatctg tccattgtga aagaggataa ctggtttgga 903901 tatgtattta tagcagcagg tgctgccatg tatgcagcca atcatgtttt gctgacaaaa 903961 gagacaaatg ccatctggtt ctgcctgatt gatattgcaa tcggcttttc gttcggattt 904021 atctttcccg gcacaggttt gttcattatt atgctttgtc cggttgcggt cgcctttttt 904081 ctgcgggggt ttcctaaaag aacagcatgg tctgtcttat gtctttcctc tattttattt 904141 ttgaccgtcc tcatccgtac atatgcgatg ttcggcaatg aatttgtcat tgatcatttg 904201 actagcatga cattcgttgt cttctgcggt gtcgtgggca aattaatccg caagctgttg 904261 gatgcgcagg atacggcaaa acagcagttt caggaactga cggagtccca tctggcgctg 904321 tctgctgcac atcaggagct ccatttatat gcgaagcagg ttgaagagct gactgccatt 904381 tacgagcgga acagaatggc gcgtgaaatc catgatacag tggggcataa aatgacggcc 904441 cttctcgtcc agctgcagct tttgcgtgaa tggcaaaaaa gagacagcca aaaagcggat 904501 gagacagtag gtgtctgtga aacacttgcc cgtgaagcgc ttgatgatgt ccgcttatca 904561 gtacgcactc tgcaaactga aaacgatcct tcgctaatcg aatcgctgaa acagctgaca 904621 gaggactttt gcaaaaatgc aggagtcaca acagaatttg cggtcagcgg tgatcctgca 904681 atcatcccgc tgtctctcca tccgaccctg atcagaacgg tgcaggaagc actgaccaat 904741 gccaaacggc acggcggcgc cgcagcctgt tcgatacagc ttgcctgcac aacggacagc 904801 atcagccttg tcattaagga tgacggcaaa ggcaatcctg aggcagcact tggttttggt 904861 ctcttgaata tgaaaaagcg ggcagcggag catggcggaa tgatccgctt tgaaagcgaa 904921 cgggatcaag gatttactgt aaatgcagaa ttttcacttg ccaataaaaa atggagcttc 904981 gggcccgtgc agcaaaagga gagtttatca tgattaagat catcattacc gacgatcagg 905041 atatcgtcag agaagggctg gcatccctgc tccagctccg agaagagctc gatgtgatcg 905101 caacggcgcg aaacggacag gaagccttcg aaaaggcgaa agagctggag ccggatatcg 905161 tgttaatgga catccgcatg ccggtttcca acggggtgga gggaacaaaa ttaatcacaa 905221 gctcgctgcc aagcgtaaag gttttgatgc tgacaacctt taaggattca gcgctgattg 905281 ctgaagcgct tgaagaggga gcaagcgggt atctgctgaa ggatatgtct gcagatacga 905341 ttgtaaaagc agtgatgact gttcattctg gcggaatggt gcttccgccg gaattgactg 905401 cccaaatgct gaatgaatgg aagcgtgaaa aacagctgaa aggaataaat gagatagaaa 905461 aacctaacga gctgctcgac ctgaccgagc gcgaaatcga agttctggct gagctgggat 905521 acgggctgaa taacaaagaa attgccgaaa agctttacat tacagaaggc acagtcaaaa 905581 accacgtttc aaatattatc agcaagctgg ctgtcaggga cagaacccaa gccgccattt 905641 actcggtcag atatggtgta tctgtctttt gacatatgac gttttgcata tacgcttctc 905701 tgaaaaggcc ttttacaggc ctttttttca tgccctatgt tctatctgcc gctacatgcc 905761 gcacgccttt ctttcttcta caatggcaat ggatcaaaaa aaggagtgag acgacgtgct 905821 gcaagcagaa aacatcaaaa aggcatacgg aaaaaaaaca atcgtgaaag gcatttcttt 905881 ttccctcaaa aagggggagt cgttcggtct gctcgggcct aacggtgcgg ggaaatccac 905941 aaccatctcg atgatttccg gccttgtgcc gcatgacagc gggaacatca cggtgggcgg 906001 ctatgttatc ggaaaagaaa cggccaaagc gaaacaaaaa atcggcattg ttccgcagga 906061 aattgcatta tatccgacgc tgacggctca tgagaatctt atgttttggg ggaaaatgta 906121 cggacttacg cacggtgagg ccaaaaaaag agcggctgag gtccttgaat atgtcggtct 906181 gactgagcgg gctaaagata agattgaaac attttccggg gggatgaaac gaagaatcaa 906241 catcggtgcg gctttaatgc ataagcccga gctgctgatt atggatgaac cgactgtcgg 906301 tattgaccct caatcgagaa atcacatttt agaaacggtc aaacagctca acgaaacggg 906361 catgacggtg atctatacga gtcattacat ggaagaagtt gagtttttat gcgaccggat 906421 cgggataatt gatcaggggg aaatgattgc gattggcaca aaaactgatt tgtgcagccg 906481 ccttgggggc gataccatca ttcagctcac ggtcagcggg atcaatgaag cgtttcttgt 906541 ggcgatccga tctctggccc atgtgaatga tgtaacagta catgaattag agctcaaaat 906601 tgacatttct gcggctcatc atgagaaagt cgtcacaagc ctgcttgctg aagccactgc 906661 tcatcatata aacctgctgt ctcttcaggt gcaggaaccg aatctggagc gcctgtttct 906721 gaatctgacc ggccgcacgt tgcgggattg aggagggacg gcaatgaaaa aaagcatatg 906781 gatcgcatgg aaagatgtga aaatcagaat cacggacaga aaagggttta tgatgcttat 906841 cctaatgccg ctcatcctaa cctgtatttt aggcgcagcg ctcggatcag ttgttgacgg 906901 aggcagccgg attgatgata tcaaagtcgg ctacattcaa tcagaccagt cagatacagc 906961 aaacatgttt acaaaagatg ttctcaaaaa aatgaagtcg ataaaggtca caaaagtcgg 907021 cagcaaagac aagatgaaaa aactgattga tgaaaagaaa atcgatgtag gcatcgttat 907081 cccgaaccat tgggaagccg gcaaaacctc agctgttgtt aatgccgctc ctgatcaaac 907141 attgaaaagt tccatcattg aaacagctgc aagctcattt atagagcaat ataaagcggt 907201 aaaggaagcc gcgtcaggct caatggacta catcagtaaa acggaagctg taaagcaagg 907261 aaaacttgac cctgcacagt ttgcagaaaa gctggcaaag acgctagaaa aagaaacagg 907321 tgacaagctt actattgcgg aaaaatctgt cggcagcaaa gccgttacca gttttcaata 907381 ctattcggcg gcaatgcttt gcatgtttat gctgtttcat atcacagtcg gggcgaaatc 907441 atttttacag gaaaaggata cggagacgct tgccagaatg ctgatgacgc ctgcgcaaaa 907501 atccgtcatt ctcttcggaa aatggcttgg gacgtatctg tttgccatca tacaattttt 907561 catatttctg atcgtcacaa tcaacgtatt tggtgtggac tggggcggta atctgctgtt 907621 agtgagtgta ctcgggcttt cttacgccgc agctgtatct ggtatttcaa tgctgcttgc 907681 gtcgtgcatc agcgatatga aaactgcaga tgcgataggc ggcttcggca ttcaattgct 907741 tgcggttctc ggcgggtcca tgctgccgct gtaccaattt ccggacgtct tgcagtctgt 907801 atccaaagcg gtgccaaatc gctgggcgct tgacggcttt ctttctttaa tggaaggggg 907861 aggctgggct gaccttcaaa agcctgtgct tctttttgcg gcgatcggct tttgttcact 907921 tgtaattggt atcagacggc ttcatacaag ataaggaggt acaaaaggtg aaaaaaattc 907981 tagccatttg cggcattgag ctttctctca tttttaagaa gccacagaac tatttgatca 908041 tgtttgctgc cccgcttttg cttacctttg tatttgggag tatgctcagc ggcaatgatg 908101 ataaggtgcg gcttgcaatc gttgatcagg acgatacgat tctctcacag cattatattc 908161 ggcagctgaa ggcacacgat gatatgtatg tattcgaaaa catgtctgaa agcaaagcgt 908221 cagaaaagct gaaacaaaag aaaattgccg ggatcatcgt catttcccgc tcgttccaga 908281 cacagctgga aaaaggcaaa catcctgagc tgattttccg tcacggccct gagctgtcgg 908341 aagcgccgat ggtcaaacaa tatgcagaaa gcgcattggc aacgctcaat attcaggtga 908401 ccgcggcaaa aacggcatct cagacagcgg gagagaactg gaaggcggcg tataaaacgg 908461 ttttcgccaa aaaacatgaa gatatagttc cggctgtaac acgacagacg ctcagtgata 908521 aaaaagaggg tgcggaagca agtgacacag cctccagagc agcagggttt tccatcctgt 908581 ttgtcatgct gaccatgatg ggagcggctg gaaccatttt agaagcaaga aaaaacggcg 908641 tatggtccag attgcttaca gcctctgtca gccgagccga aatcggtgct gggtatgtgc 908701 tgtccttctt tgtcattggc tggattcaat ttggaatatt gcttctttcc acccattggc 908761 tgtttggcat caactggggg aatccggctg cagttattgt attagtgtca ctttttctat 908821 tgaccgttgt cggcattgga ttgatgattg cggccaacgt cagaacgcca gaacagcagc 908881 ttgcgttcgg caacttgttt gtcatcgcaa catgtatggt gagcgggatg tattggccga 908941 tcgacattga accgaaattt atgcaatcca tcgctgaatt tcttccgcaa aagtgggcga 909001 tgagcgggtt gacagagatt atcgctaacg gtgcccgcgt cacagatatt ctcggaatct 909061 gcggcatttt gcttgcattt gctgcgatca ctttcgcagc ggggctgaaa gcgctccgag 909121 cctaaaaaac atctgccgtt taggcagatg tttttttgca tgtgggtaca ttcgtatggg 909181 tgcagcctga actgcggtta atccttatct atcatagcta aaattgattc cagccaagaa 909241 acgtaatttt tctcccgctc cagcgctttc gttagcacaa gatagtggcc gaagtccggt 909301 gaagaaaatg acatcggctc tgctgaagcc ataagctttt catagcttcc ctgtaagtca 909361 gaaagcttgg cctggcgttt ttgcagctgg tctttgaaca aatcagaagc ctcctggcgc 909421 gatagacaag aaatgaaata agccttcagc ataaattcat ccttcaccgt ctcgggtatc 909481 ggctggtggc ggatcagcca gtcatgcagc tcctgctttc cgctgtctgt cagggtgtac 909541 atctttttct ccagctttgt gccctgaatc gttgtccgga acgtgataaa tccttcatcc 909601 gtcagctttt tgagctcagg gtaaatctgg ctgtgcttgg cgctccaaaa ctggccgagc 909661 tcctctttaa aataactcgt aatatcgtat ccactcaatt cgccttttcg caaaagccct 909721 aatatggcgt attttaatac tctcatgcta tcctccgtgt ctggctgttt cgcaaaacag 909781 atgagccggt gctcaactgt gattctaact gcctattccc cttattatag aaaagggagg 909841 aagggaacac aaccgggctc tttggaaatg aagataaaag gtttgtcaga aggtatccga 909901 tttatctccg tcaatataaa agagatttaa atttaatttt cagaaaaaat agtaacgata 909961 ttgatttttt atatataata ggaaattggt ggtatgaaaa ttttttgggg gaataaacgt 910021 gaaaaaagta cttatggcat tcattatttg tttatcgctg attctatctg ttttagccgc 910081 tccgccgtct ggcgcaaaag ctgagtcagt acataatcct gtcgttcttg ttcatggaat 910141 aagtggtgca tcatacaact ttttcgctat taaaaactac ttaatttctc aaggctggca 910201 aagcaacaaa ctgtacgcaa ttgattttta tgataaaaca ggaaacaacc taaataacgg 910261 cccgcagctt gcttcatatg ttgaccgtgt tttaaaagag actggggcaa aaaaagtaga 910321 tattgtggct catagtatgg gaggcgccaa tacgctgtac tatattaaat atttaggcgg 910381 gggcaataag attcaaaatg tcgtaacgct tggaggggct aatggtttag tgtcatcaac 910441 cgcgctgccg ggcacagacc ctaatcaaaa gatcctctat acatctattt acagtctcaa 910501 tgatcaaatt gtcatcaata gcttgtctcg gttacaagga gcgcgaaaca tccagcttta 910561 tggcatcggt catattggct tgctttctaa tagccaagtg aacggctata tcaaagaagg 910621 gctgaatggc ggaggcctca atacaaatta atatcttcaa aaaacaacct gctgtctccg 910681 ttacagtggg ttttttcgtc tgagaaagcc atagggtctt atgaccttag tctatcatgc 910741 atacgtcaat ttatgacatc aggcactttt tcaaatagag cggacatgtt aaggtacaac 910801 catcgatttc tatcaatttg aaataaaagg agcgctgtta tgcaaattaa agaaattttt 910861 atgatccgct gcatttcgtg cttaagtgtc gtcttgctcc atatcatttc aatggtcctg 910921 atgcttcagg cagaagctct tgcagatatt tctcacactg ttgattcttt ccgcacactc 910981 ctgatgttca gcacgcccgc ttttattttc atctctgaat ttttactggc ccgttcttat 911041 cctgatgggg tgcctgacgg ttttttaaag aagcggggaa aagtgatttt tgttcctttt 911101 ttatttatcg cagccatcga tgcgctgctg atgaccagtg cgatgggggg agaggtaacc 911161 tttctcgcgt ttgtgcaaaa atatctggcg aacgtattct taggaaactt tatcggatac 911221 ttcattctcg tcatctttca attttacatg ctgcatatga tgtttcatga gtatttgaaa 911281 aaagcatcgc cgaaatgggt gctgtctatc tcatttgtgg tgacagccgc ttatttaggc 911341 tatttctccg cagccagccc ggctcctgct tctgaagagg gaggggcatt tccgttcttc 911401 tgggttccgt tcgcaggctg gcttttctac ttttgtctag cctactattg cggaaaagaa 911461 tacaagcgtt ttttagcgct gctgaaccaa taccgctggg tggtgtacgg cgccgcaatt 911521 gcttctgggg cgctggttgt cactgtttct tatgtcggtg aaatcggcat gatcagctcg 911581 aagcggcctg atatcatgct gtattcaaca agcatgattt tcctgtgttt tcatttgttt 911641 tccaaaatga agcatgtgcc gaaaatcatg atgtttatca gcaactattc cttttcgatt 911701 tatctgcttc atgcctattt tatgattata ggctacgtgt tgcttttgaa tatgcccgaa 911761 attcctgccg taccggctgt tctcctgttg tttgccgtgt gcacagccgg cccgattatg 911821 acctcatggg cgctgaataa gttcaaatac gggtatttat ttgtggggaa aatttatcag 911881 ccaaaacaga agaaggtaac agtcgaagtg cgtgatcacg cagggtgaaa aacaagcggc 911941 aggagggctc ctgccgcgtt tctttacttc tcatccgctt gcagaactgt ttttaaatat 912001 agttttgcag actcagcaag tccagataca tcagcctttt cttcatcgaa atacagggcg 912061 ttttgaatga tgccgtcatt catattgagg aaaaacttgg cgatagtcgc aagaggctga 912121 accggctgaa actctccctg atcgatccct ttttgcaata gccttgaaaa cctttccaca 912181 aaaagatcat accttttctc caaatactgc cgccgttctt cattgcgcca agctgtcact 912241 aaatattcaa attgcaccgg cgccagcgta tctgctacat ctcgcaggcc ctcagtcagt 912301 tcatccaaat agctggaaat ggaggcccaa acactttggt gttcagctga tttatcaagc 912361 tttcggagtc cttcatccag ccctgtttca ataatgcggc gaaacatctc ctcagtgctt 912421 gaaaaataaa gatagacacc gccccggctg aaacctgact cttctacaac atccttcatc 912481 gtcgttaatt cgaatccttt tcgtttaaaa accgttttgg cagcctctaa aatctctgcc 912541 tgccgtttat ccttgtgctc ctttgttact tttggtgaca agatatcgcc tgctttctgc 912601 aattttctta cctataagtg taatcaaccc aatcatgatc agcaagcagc cacagacaag 912661 aaaagcaagt gatacaccga tccattccgc cagcacgccc ccgcccgcca tgccgaggat 912721 agaggcgagg gttgtcgcac tctgaatagc gccgaacacc ctaccgctgt aatcgacagg 912781 cactgttgtt tgcacgagaa tctgaaatgg aatatggacg aggccgaaag ccgcccccat 912841 gatgaaaaaa gcaaatataa agagagtgat gccggcaatt cccataccgc ttaggaatgg 912901 cgcacctcca gttgctagtc caagaagaag ggttccagct gagaaataaa gcaaataaga 912961 agtgattcgc cgtctgccgg taatggccgc tgtaaggagc atcccggctc cgcttacggc 913021 catgcaccag cctgccagct cgggcggagc tcctgaaaag gagcggataa gaataatcgc 913081 ttgggaatca ccaatctgca aaacaaagag aacgacacaa gctgttagta agcctgttaa 913141 tagaagcggc atccgtttca aaaactgaag gccttccttg atagaagtaa gtgctgctgt 913201 tttttcttga ggtgtattgg ctttttgtaa aaaagcatct ctgggaagga aaaacaaaat 913261 gacagcggaa agaaagaagg cgccggcgtt tatataaaaa acagagtgta tcgagaaagc 913321 agcgatcagc gtgccgccaa gggcagggcc gaagattttt gagctgttat caatgatgct 913381 gctgacggaa acggcctgct gaatgtgtgc ttccggagcc aattccttaa gctttccgtt 913441 tttagcaggt aaaaaaagtg aagaaaaaca gctctgaacg gatagcaata cgtaaagctg 913501 ccaaagctca ctgacataaa cgcagctgat aacagtgagg gcacggccga tttcagatag 913561 aaacatgatc gtttttctgt caaaacggtc ggcaagcaga cccgatacag gtccgagtac 913621 aatgacaggc aaagcaaacg acatcattaa aagcgacata tctaatggag aagcatgaag 913681 ctgaaaagcg gctaatgtta gcacggccaa aatgtgaagc cagtctccaa gtgaagaaat 913741 ggtttgcgag gctaacagtg tcatcagtcc tttttgattg cgaaacaacg gtttttccat 913801 gattcatcct cctgattatt aaaatgacac tagtgtcgtt tttaattgta tgggaaaaag 913861 acacaatata caatcttttt cttgtaaaat aaaggagaag attgaataga agggagaaca 913921 ttcatgacat cagtcaatct aagctaccca ataggagaat acaagccgag ggaatccata 913981 tcgaaggagc aaaaagataa atggattcaa gtacttgaag aagtgccggc aaaattgaag 914041 caagctgtag aggtcatgac ggacagccag cttgacacac cgtaccggga cggtggatgg 914101 accgttcggc aagttgttca tcatctggct gacagtcata tgaacagcta tattcgtttt 914161 aaattgagct tgacggaaga gacaccggct atccgtccgt atgatgaaaa agcatggtcg 914221 gagctaaaag actcgaaaac ggcagatccg agcggctcac tcgcgctttt gcaggagctt 914281 cacggaagat ggacggctct gctccgcacc ctgacggatc agcaatttaa gcgcggattt 914341 tatcaccctg atacaaagga gatcattacc ctggagaacg cgctcggcct gtatgtctgg 914401 cactcacatc accatatcgc tcatattacg gagctttcca gacggatggg gtggtcttaa 914461 cgcttttgcc ggcggaaagc cggaatactg atagcagcaa tcaccagaag tgagaccaca 914521 gcagccgctg catataaatg atcatagccg ctggcgacac tcgcatgaat ggcgtcgctt 914581 atcgcggttt tgacttcagg aacgggaatg cgttcgattt gttcttgtaa agaagaaact 914641 tcagaactgt cgatctccgg aatcatctgc atcgcctttt ctgaatatcc gctgtccgat 914701 aagcggctgt tgatctcatc acctatttgg tcaaacccgg ctgtgataaa acctgcataa 914761 agagtaggcg ccaaggtcag tccaatttgc cttactaatg aaagcgtgcc aagagctgta 914821 cccttatttg tttttgccgc ttctgataca aggacgttca gcggagcgcc taacagaaag 914881 ccaaaaccga tcccagctgc cacacttgcg atcacaaact cccatttttc cgtgacccag 914941 agcggaaata aagcaaaccc cgcacatgag atgattcccg aaagaataac ggtttttaca 915001 ggaccttttt tgtcggtaag tgctccgcca agccaagcgc cgattccgga agccaacgca 915061 agcggtgtca tccaatagcc tgcttttgcg gcagggacac ccaaatactg ttcgacatat 915121 gacgggataa aaatgactgc cgccaagagc cccccggata acaaaccgat gataagcgtg 915181 cgctgaaaca tatggtttcg cagcagagaa tacgccaaaa tgggatcgcc tcctcgcatt 915241 tcaactctct tttcatacga gataagcgct gcaaaacaga gtatgccaaa aataatacat 915301 ccataaacct ccggattccc caagctgtgt aagagatttg ccccgtcaag attggtcatg 915361 ccgtacatca cagctaaaat cgacagggac aaaaggaaga ttccggccgc atcgaggcgc 915421 ttagcctcag gtgcttttgt ttccgcgata aaacatgcgc cgaaaacaac caatagcacg 915481 gcaatcggca aattaatcaa aaatagccaa tgccaagacc cggtccaatc aagcagaaag 915541 cttccgatat ttggcccgag cacagcggcc atcccgttca ttgcgccaag cagcccaagc 915601 gccttcccct gtttttcctt tggaagggtc gcgagaatgt gagagctgcc gatgatgaaa 915661 atcccgccgc ctccaagcgc ctgaatcagc cgcgatatca gaaagagcgg gaagctttgg 915721 ctcaaagcaa caagcaaaga accaagtccg aacaggcaaa cctcaatgag aaagagtttt 915781 tttctgccgt agcggtcgga aagttttccg acgattggca cactgacgct aagaccgagc 915841 gtataaaggg taatgcccca tgatccccag gaaggggaaa cggaaaacga ctcgtttatc 915901 gttgttaaag cagccgaaat aattccgtta tctaaagcag ccataaacac gccaatcgta 915961 aacaggctga ttgcccactt ttggcttttc tgctctgtta atgcttcaga cattttcgtc 916021 aactcctttt agttcacttg aaatatatta ttcattttaa atgaactaaa tgtcaaataa 916081 aaaaagcctg ctcccgcagt ttgcggatga cagacttact gatttattct tttttcgcat 916141 tctctaatgc tcttgaaagg atagacagcc cttcgtaaac agcctgcttt tcttcagggg 916201 acagcagctc taatgaacgc ttcaatttca ggtggccctt ttcatacaaa ccccggaaaa 916261 tctttttcgc attctctgtc aactgaacaa ctacagagcg gcggtcctct tcagaatgtg 916321 agcgtttgac aaatcctgat ttttcaagcc ggtcaagcag cccagttgta ttggacaggg 916381 aagcccccat tttttcagca atgtcgctca ctttcaatgt tccatggttg tttaatagca 916441 tcagcacctt catttgcggc atgctcatat ccagtttcat ccactcggac acatcaccga 916501 gcccggcgga cgttaagact ttcatataga gcacccatat ttcccgttcc tccgatgaaa 916561 gaatgttttc gtttaagact gttgtatcgt gtaaattata ttccatttca tcacttcctc 916621 atcattcact cctcttacca tattactcga ttttcactcc tgaaagaaag tgagcagaaa 916681 ccgcatgcgg gactttgtcc gaaaaataac ggtagtgtat aatgagttgg agattattgg 916741 gggagaggat cgaactagaa tatgattgga gagaccattg ctgattaaaa agaatgcttt 916801 atcaatatta aaaatcgttt ttcctattgc tgttttgcta tttgttattt atcaatcgaa 916861 aaaagaactg acaaatctgt cattcaaacg tacgctcatg gtcatcaacg gactggaacg 916921 aacggattta ttcatgcttg tgttgatcgg cttgctggct gttgcggcta tgtcgctgta 916981 tgattacgtc ctgaagtact cactgcgcct atcgatcaca aacggaaaag ttttcagggt 917041 ttcctggatc gccaattcat ttaataatgt gttgggattc ggcggtttag ccggagtcgg 917101 gttaagaatg atgttctata aggagcatac gaaagaccat aaggcactcg tgaaaggaat 917161 cgcctggctc acatcatcta tgctgctcgg attatctgtt ttcagcattt tcgttgctgc 917221 gagagtgctg ccagttgatg aagtgattca tgagaagcct tggctgtggg cggtcgttat 917281 cggttttgca ctgatattgc cgttatcttt agcggtgtcc aaaataaaag accgcaaagc 917341 tggggacgaa gagaatgcgg ataaagtgaa aaatccgatt ttcgcatata ttggagcttc 917401 agttgttgaa tggctcatgg ccgggaccgt catctatttt gctttgttcg ctatgggcat 917461 tcatgcagat atcaggtatg tgttcggggt gttcgtcatt gcggcgatcg gaggaatgat 917521 cagcctcgtg ccgggcggct tcggctcgtt tgacctttta tttttgctgg ggatggagca 917581 gcttggctat catcaagagg ccatcgttac ttctattgtg ttgtacaggc tcgcctactc 917641 atttatccca tttatcttgg gactgttctt tgccgccggc gacctgacgg aaaatacaat 917701 gaagcggctc gaaacgaacc cgcgcatcgc accggcaatt gagacgacaa acgttctgct 917761 tgttgttcag cgtgcggtat tagtgagaat tttgcaaggc tcgctttccc ttattgtgtt 917821 cgtagcaggt ctgattgtct tggcctcagt ttccttgccg attgacaggc tgacggttat 917881 accgcacatt ccgcgcccgg cgcttttgct gttcaacggc ctgtccttaa gctcagcgct 917941 cattctgctc attttgccga tcgagcttta taaacggaca aaacgttcct acacgatggc 918001 cattacagcg cttgtcggcg gctttgtgtt cagcttttta aaagggctta acatcagcgc 918061 gatattcgta ctgccgatga ttatcgtatt gcttgtgcta ttgaaaaaac aatttgtccg 918121 cgaacaggca tcctatacac tgggacaatt gatattcgct gtggcgctgt ttactgtggc 918181 gctctttaac tacaatctga tcgcgggctt tatttgggac cggatgaaga aggtgctgcg 918241 tcacgaatat ttcgtccaca gcacctcgca tattacacat gcaaccatca tggcgatcat 918301 cattgtgccg ctgttcttct tgatatttac agtggtctat cataagagaa cgaaaccgat 918361 cggagagaaa gctgaccctg agcgtcttgc tgcgtttctc aatgaaaaag gcggcaacgc 918421 gctgagccat cttggttttc ttggagataa gcggttttat ttttctagcg atggaaatgc 918481 actgcttctg tttgggaaaa tcgccagaag gctggtcgtg ctcggcgatc catctggcca 918541 aagagaatca ttcccgctcg tgctggaaga atttctgaac gaagcgcatc agaagggatt 918601 cagtgttttg ttctatcaaa ttgaacgaga ggacatggcg ctgtatcacg attttggcta 918661 caacttcttt aaattgggtg aggaagcata tgtagattta aatacattta ccttgactgg 918721 gaagaaaaaa gccggccttc gggcaatcaa taaccgcttt gagcgggagg agtatacttt 918781 ccatgtggat catcccccat tttctgatgc gtttttggag gagctgaagc aaatctcaga 918841 cgaatggctc ggctcgaaaa aagagaaggg attctcgctc ggattttttg atccttccta 918901 tttacagaaa gcgccgatcg cctatatgaa aaatgcagaa ggagagatcg ttgcattcgc 918961 aaatgtcatg ccgatgtacc aggaaggaga gatatcggtc gatctgatgc gctatcgcgg 919021 cgacgctcca aatggcatta tggacgcatt gtttatccgt atgtttttat gggcaaagga 919081 agagggctgt acgtcattta atatggggat ggcacccttg gccaatgtcg gcactgcctt 919141 tacatccttc tggtccgaaa ggtttgccgc tgtcattttt aataatgtca gatacatgta 919201 cagtttcagc ggcctaagag cctttaaaga aaaatataaa ccggagtggc gagggaaata 919261 cttagcgtat cggaaaaaca gatctctttc tgtcaccatg ttcctcgtta cacgtctgat 919321 tggcaaaagc aaaaaagact ccgtctaata agacggagtc tttttttatt tcgtttttaa 919381 gaagtaggtt tcaatatcat caagcaggta gtttgcggct ttaattccgc ctgcggttgt 919441 ccatacgacg tcatcgactt catgtgcatt acctgacttc acggccttca ggtttttcca 919501 tagtgaactg cttgtccact gattggccca tttttcattt tcttttgcat tatcggcttt 919561 ataagtgaaa taaaacagca catcagcatc catatcagga atagattctt tactgtcggt 919621 tgagaacgta aattggtcct tttgtttctt aaacagttcc acttgttttt cagggcgttt 919681 gaagccaagc tggtctaaaa taatcccagg aaatgaatcg gtataataga ttcttgattc 919741 accggataaa aagcgtacga ctgaaacggt tttgtttgtc tggtcgccca gcttgttttt 919801 taaatcagaa acacgtttat caaaatcggc aatgacttcc ttgcctttgt ccgccttatt 919861 caccgcgttg gcgtatagag tcaggttatc cttccagttc ccggccaaag attcagcaaa 919921 aacagtcggc gcaatcgcat ttaactgatc ataaattttt tcctggcgca ctttgtttcc 919981 aataatcaaa tcaggcttta attctgcgat ggcttccaca ttcggttccg tttcaagacc 920041 gacgttttta acacctttca tgtcatcttt cagatagtca taccacgggt cgcccttcca 920101 tgactttacg gctccgaccg gcttaatgcc aagcgctaag agcgcctctg ttccttcatt 920161 agttaaaaca acaatccgtt ttggattggc ggggatgttg tctgatgtcc ccattgcatg 920221 tttgaccgtt cttgttttgc tgcttgacac ctcgctgttg cttgaacttt ctgaactatt 920281 acaggcagaa agtaccataa cggccattaa aaatacgaat agcatgctga tatgcttttt 920341 catctttttc ctcccaatat tgaaattcat tatcatttag atcataataa gcagtgttaa 920401 gagtgtcaat ccctaattga ggattattct caaaaacaaa cattacatag taaataacta 920461 ggagaattag atcatgatct gcaaaaaggc atcttcaaaa tggattgtgt tagtatgtct 920521 gattttcatt ttactgacgg ctgtctgcgc aagcgtcgtg tatggctata caggtacgtc 920581 atggagacag gtctatcagg cgtttacttc cttcaatgga acaaatgagc atgtcatcat 920641 caaggatgtc aggcttccgc gcgctttggt tgcgacagtc gtcggcgcct cgcttgcagc 920701 cgcgggcgct ctcatgcagg cgctcacaaa aaatccgctt gcgtcaccgg ggattttcgg 920761 gattaacgcc ggtgcaggtt tttttattgt tgccggatcg ttttttctgc atattcagtc 920821 acctcaggca ttagtatgga gctcgtttct gggggcagca tttaccgctg cgatcgtcta 920881 tgcagcaggc tcgcttggga gggaagggct gacgccaatc aaactgacgc tggcgggagc 920941 tgccatggca gccatgtttt cttctctgac acagggcttg ctgtctgtca acgaactcga 921001 gcttgcccag gtgctttttt ggctgactgg ctctgtgcag ggccggagtc tggatctgtt 921061 gatgacgatg tttccatatg cagcggcagc gctggtaatc tgcttctttc tcggccaaaa 921121 aattaatctc ctcgttatgg gagaagatgt ggcaaaagga ctcggccaaa aaacaggcct 921181 gctgaaattt gtgatggcgc tttgtgttgt catgcttgca gggtccgctg tcgccattgc 921241 cgggccgatt tcttttatcg gcatcattat tccgcatttt gcccgctttg tcgttggtaa 921301 tgattatcgc tgggttctgc cattttccgc tgttttgggt gccattttgc ttgtttgcgc 921361 ggatatcggt gcgcgatata tcattatgcc tcaggaagtt cctgtcgggg tcatgaccgc 921421 catcatcgga atgcctgtgt ttgtgtacat cgcaagaagg ggggcgaagc tatgaaactt 921481 cgttttggcg ttactgcggc tgaaaagaaa gcatggatcg tctttttggt tttactgggg 921541 ttaacagctg ctgtactcat cataagcgct ggtctcggac aaaggtttat tcctccctgg 921601 gatgtagcaa aaacattctt tggtgcaggt tccaagctgg atgaactgat gatcatgtcg 921661 ttccgcatgc caagaatttt gacggcttta tgcgccggtg tctgcttggc agcggcaggc 921721 gcgatattgc aggggctcgt cagaaaccct ctcgcatctc cggatattat cggaataaca 921781 ggaggagcgg cggtagcggt cgtgctttta atgatgttct tctcagaccg cagcagttca 921841 cttacgatca gtctgtcatg gcttccagca gccgcattta tcggcgcatc ggctgtcggg 921901 ctcatcgtct atttactggc atacaaaaat ggcgcctcca catttcggct ggtgcttatc 921961 ggaatcggat tttcaatgtc ggcgcaggcg atgactaccc tgttgatgat caaaggcccg 922021 atttaccgag catcacaagc caatgtgtat atcactgggt cagtttatgg gtcaaactgg 922081 cagcatgtaa aaatagctat tatcttatct gtcattctct tattcatttg ttttgtcgcg 922141 ctaaaaaata tgaatataca ggtgctgggt gaagatattg cggcgggtgc aggaagcgct 922201 gtgcagcgaa atcgtttttt cttgctcctt ttgagtacgg ctcttactgg ttgtgcagtt 922261 tcagttgccg gcacaatcgg ttttgtcggg ctgatggcgc cccatattgc aagacggctt 922321 gtcggctcat cttatggcgc gctgctccca gcgtcggcac ttattggagc tctgctcgtt 922381 ttaacagctg atatcgtcgg cagaacctta tttgctccgg tggaagtgcc ggccggcgtc 922441 tttacagcgg ctatcggcgc accttatttt atttatttgc tctataaaac aagaaattct 922501 taatcgttac acccattttc ttaaaaaaga aaatgggttt ttttgataat gactgaagat 922561 tcgtaattat ttttgctata ctgacagaga cattgataaa gaaagggcgg cagatgaatg 922621 aaagaagcag aggtattaaa atatgaagca tttacaagca gtcccggcaa aggaaacccc 922681 gcaggcgtcg ttttgcaggg agacgattat acggaagacg agatgcagat catagctgaa 922741 cgtgccgggt attcagaaac ctcctttatc cgaaaaagcg agtcggccga tcttgaactc 922801 cgttacttta cccctggaca cgaaatgaat ttgtgcggtc atgcgacagt tgcttctctt 922861 tacgcattat gtgagaaagg aatgctggag agcggtaaaa cgtacagcat ccaaacgaaa 922921 gcgggtatcc tgcctgtgaa gatttctgaa aaagatggcc gcattcatat cacgcttgaa 922981 caggcctctc cgcaattcaa accatttaca ggcgatcgga aaaaacttgc ggacgcactg 923041 ggtatcaccg atgaagattt tcatgaagac cttccgattg tgtttggcag cactgggata 923101 tggacagcca tcgttccgct taaatcattg gaggcttcca aaaaaatggt gccagataac 923161 aaacaatttc cggaagtgtt agttgatctg ccaaaagctt cagtccatcc gtttaccttt 923221 gaaaccgtcc atcccgacag cgacctgcac gggcgccact tttcatcccc gtattcggga 923281 acgattgaag accccgtgac cggcacagca tccggcgtga tgggggctta tatgaaacat 923341 tatggcaatg ccgagcagca taaatttatc attgaacaag ggcaggaaat tggaaaagac 923401 ggaaaagtgg agatcgaaat gaacgaagcc ggcggccatg tgaaagtgaa catgacagga 923461 acagccgttt actcagaaac ccgtattctt aaaatctaat acggatgatg gtttacaaaa 923521 agatgcactt tccgttatca ttatgaaatg ataatcattt tcaattgcat aggaaggtga 923581 gacggtatgc ctcaaaccga acaaatacat cagcattcag tactgaggga catcatacgc 923641 agcagaagat cgattcgaaa gtttaaacaa gagccagtac cttcagcagt cattcttgac 923701 atgcttgaaa cggcaaaata tgcgccaaat cacagagtga cagagccatg gagatttatt 923761 tacgtttcca gtgagacagg taaagcgaac ctcattaata catttgcagc gttctctaag 923821 aaatccaagc cggatatgac agaggaaaag cttcaaaatt tcaaaaacac acttgggcgc 923881 gttccgggat ttctcctcgt cgtgtttcag gaagatgaaa acgaaagagc gcgggacgac 923941 gattttgcgg caacaagctc gttgattcaa aatcttcagc ttctcgcttg ggaaaaagga 924001 atcggcatgg tttggaaaag cggaaaaatc ctttatgaca aagaagtcca tcaggccttt 924061 ggtttacagg ataatgagcg tttcgccgcc atcatacaaa caggttatcc tgacgaggcg 924121 ccggaagtga aaaaacgcac accgatccgc gaccgattca ctgaaatgta aaaaacccct 924181 tgtctcaaac ggagacaagg ggtttttcat taacgagatt tctttttcgc tctgttgtcg 924241 gctgctttcg cacgctcttg cgcttcgcgg tcatctgcat cagcaagctc ggttgaatat 924301 tcttcgtaaa cgccgtcagt ttcccttttt aaggcatcgg gaacttgtgg aagcttttgt 924361 ttgtttttat cacggttttt gtggatatga tttctgccca tatcaaattc cccctaaaaa 924421 gtgatatcaa acaaatatag tatttggttt taaggggcta tgtattccta cttccgctta 924481 gcagcttttt ccgctttttt aaattcgcct gaataaagaa cttcctgcat ttttttcagg 924541 ttggcgcctt gctggtgctt ctccctcttt ttttccataa aaaggacctc cttcaaccat 924601 gttattctta aggttgacgc ttcctgctgt ttttatacag tctttcggtc cgctatcagc 924661 tgtgagagtg caaattcaag atccgaatat gtaaaacgaa atccagaggt tatcgctttt 924721 ttcggaagag cgcgctgtcc tttcacaatc aaaagactca tttcacccaa tgcttttgat 924781 aaaaagaatt ccgggacggg gagccagtgc gggcggtgct tcacccgtgc aatcgttttt 924841 ccgaattgct tcatgtccac aggattgggc gcggtgacat tcattgggcc tgagatgccg 924901 gcgttttcca ccgcatatcg gatcatctgg gccgcatcct cgacatgaat ccatgacagc 924961 cactgccttc ccgttccgat cgttccgccg gccagaaact tataggggag aatcatgagc 925021 gggagagcgc ctttttctcc aagcatcacg ccaaatctcg cataaactgt ccggatgccc 925081 atcgcttcaa tatgctgtcc ttccttttcc cacaggtgtg cagtatggct gagaaaatcc 925141 tcatctgacg ttgcagaatc ctctgtgaaa gttttctcaa ggcttgtgcc gtaaatgccc 925201 acggcactgg cttggatcaa tgtcttcggc ttctccttct gtttctgaat aagccgctgc 925261 acttcacgcg tcgcattgat acggctggag agaatgtgct gcttcgtttt ttctgtccag 925321 cggccaaaaa tcgattttcc cgcaagattt atccagacat caatatgagg aagttcctgc 925381 tccggtgcgg ctccttccga cagccattgg acatatgtca tatttttttg ttcagtttcc 925441 cttgcgtttc ttgataaaat ataaacatgg tgtccctggc gggtaagaac gcctgtcaga 925501 tgctggccga gaaaaccggt tccgcccgtc attgcgatat tcatgaacat ctctcctcat 925561 cgttctaata aatatacttt acctcattgt aataaaagaa aacgcgtttc aggcctgaga 925621 agggagatta agatgccgtt tattacaaaa atatcaacgc aaaaaaagaa tacggaacgc 925681 ttcaatattt ttctggatga taaatacgcc ttcagcgtgg acgcggatgt gctcgtgaaa 925741 tttgagctca agaagggaaa agaactcgat gatcttgaca tcattgagat tcaatacggc 925801 gatgaagtga agaaaggctt caaccgtgcg cttgactttt tatcctatcg aatgcggtcg 925861 acgaaagagg tcgaggatca cttaaagaaa aaagaaacct cgccccccgt cattgcggaa 925921 gtcatccata ggcttaacga ttacaagtac ttaaacgacc aggaatttgc cgcagcctat 925981 gtcagcactc acaaaaaaac aaacggaaaa ggccctgatg ttttgttcag agagctaaga 926041 gcgaagggaa ttgatgacga tacaattaag gaggcgctaa gttccttttc ctttgaagat 926101 cagacaagag aagcggtcaa gcatgttgaa aagcttctca aaaaagataa aaagctttcg 926161 acgaaagaac tcaaacagcg cgcccagctg cagcttcagc gcaagggctt ctcatttgat 926221 gttatcagcg cggcgatgga tcagattgaa tatgaaaatg atgaagacac agagaaagaa 926281 gcgctgcgcc ttcacgcgga aaaagcgttt agaaaatacc gctatgacgg ctcatatgaa 926341 agcgccatga aggtcaaaca atttttattc cgcaaaggat tctcactcga tttaatcgag 926401 caattactgc aggaagagga gtactgaaat ggagaaacga tacagtcaaa tgacaccgca 926461 tgaactcaat accgaaatcg cattactttc tgaaaaagca agaaaagccg aacagcatgg 926521 aatcataaac gaactggcag tgctcgaacg gaaaattacg atggcaaaag catatttgct 926581 gaacccggaa gattactcac cgggagaaac atatcgtgtg gaaaacactg aggacgagtt 926641 taccatcagt tatttaaatg gcgttttcgc atggggatac aggacctctt cccctcagca 926701 agaggaagcg ctgccaatct cagtattgca agaaaaagaa taaagcgtaa caggaggctg 926761 atgatcagcc tctttttgtt tgcagcacat ttacacgaat tcttaaagaa aaaatcattg 926821 aattcacttg aaaaatcttt taagatgaaa ctcgttgttt tttaaaatca aaggaggcga 926881 tgacgttgag tatcaaaaac ccatctgtaa aatttattat atttgttctt atgatttgta 926941 cattttcaat cggctataca gaatacgcgg tgatgggtat tttgacgtcg attgccaatg 927001 actttcatat acaggtttca tccgcagggc ttcttgtcac ggcttatgcg gcaagcgttt 927061 gtttgacagg gccgctcgtc accatcattt ccgtcaagct tccgagaaag cctgtgcttc 927121 ttgggctgat ggcgatattt atcctttcca acctgatgag cgcactggcg ccgaattttg 927181 cggtattggc catttcaaga attttatctg cgtccattca cggcgctttc ttcgcgattg 927241 ccatggtatt cgcaagtgaa atggttccgc cggaaaagcg tgctgcagct gctgcttcaa 927301 tgaacggcgg actgacagtg gctctaatgc ttggtgttcc attcggctct tatctcggag 927361 atgtcctgaa ttggagagcg gtgttttcca tcattacggc acttggtgtc atcggatttt 927421 taggccttat ggctgccgtg ccgaacagaa aaccaaaagt gatcccaatg cttatgaatg 927481 agtggggtgt ttttaaacac aaacaagtgc tgttttcctt cgcgattacc attttaggct 927541 attccggtgt ctttatcgcc tacaccttta tcgaacccat tttgaggcat tcagccggat 927601 tcagcacggt tggcattaca ggtgctctct ttgcgtatgg attgggaggc gttgccggga 927661 atttctttgc tggaaaggta ccgctgcctt tgctgactcg gacgatgatc ggcgtaatga 927721 tcggtttaat cggtgttctg gctgtatttc cttacatcgc catttacccg gctgcagcca 927781 ttgtggcaac gttcctattc ggggcatgcg cattcggcac gccgcctctt ctgcaaacaa 927841 aggtcatttc ctcatctgag ggcggcacaa ccattgccgc agctgtcagc gtatcagcat 927901 ttaaccttgc caatgccctt ggtgcatgga tcggcggaat gattttaaac ggaacaggct 927961 cttattcctg gctgtttgca ggaggtgcgc ttatgaccgc atgcggactt gtgctttcta 928021 ccttcgcaca cttatcagaa aagaagagcg tctacgaata tcaagtcaat aaagggtaaa 928081 aaacagctgc agtgtatgca gctgttcttc tttaccgttt gcctgaggct ctcattcttt 928141 cttgaggatg ctgattgata gatccgtcag cacgctttga agcatagtcg tcctttgctc 928201 tcggttcacc ctgaaatttg ttttcgtttt cgtaaggaaa tcctttttct ttatttcgga 928261 ccatgtcata tccccctagg ttcgagatca aaaagttgcg tcttttcaga tgaagacgta 928321 aggttagtat atggagaaca ccacgtaata aagcgttatt tttttcctga agaaaggaga 928381 ctgcacacat gaatatgtac attgagaaac tgactaatct gcttctggaa aagaacgaga 928441 tgatcagcta tatacaggca aaaacgtggg tggaattgtt atggagcgat ttcgaagcaa 928501 cctacgcaaa agccggacac gcctatcaag gtgaaaaaat gactgaaaaa atcgtcacac 928561 aatggattga aaactatggc ggccagctcc acctttttca aagctcccgt aacgacgtga 928621 atgattactt aaatcaaagc agaggccttt tgcattaaaa acctgccgtt aacgaccggc 928681 aggttttttc attttcttaa aattacctta acaggaagaa atcataaaca aaacatgttt 928741 caccagcctg tcaatcaggg aataccactt atatcttgtc aaaatgcgag gaggagcttt 928801 atatgaaaaa gaaacaagta atgctcgctt taacagctgc cgcaggactg ggtttgacag 928861 cacttcattc cgctcccgca gcaaaagctg cgccccttca cgacatatct gtcagcatgc 928921 catcatccga tacttacatc ataaaagcag gaaagctgaa tgtccggact gagccaaatc 928981 atgaaggtga tattctcggc actgtatcat cagaacaaaa ggtaaaagtc gataggttcg 929041 taaatgccga ttgggctcaa attcatttca aaggaaagaa agcatatatt tcaactcact 929101 ttttaatgaa aaccgcaagc caagcgaaaa caacgaaaca gacagccttc tatacaccga 929161 cgcccgaaaa cggaaaagct aagcagctct catctggaac agaggtgaca atacttgggt 929221 ggggattcag tgaaaacggc ggatttgact tcacttgggc gttcgtggat tatggcggag 929281 ttaaaggcta tattcacaca aaggatttac aaatgcgata aaaaggcagg ccgaggcttg 929341 tctttttgcc tatgcatgaa acatttcttc tttctgcacg taacaatgag aaaggagatg 929401 atgatatgac gggtttagtc ggcggagggc ttatgatcat tgcgggcata ctgatcaaac 929461 tgtttcctcc caaatcgatc aacagtgtgt acggatacag aacgagacgc tcaatgtcag 929521 atcaaagatt atggaatgaa gcgaaccgtt acagtgcatc attaatgatc ctgtcaggct 929581 tggtgattgc gggaatgggt ttgctgctgg gatcaaactt gtttattctt cagcttatcc 929641 tgctgattgc cgcctgtgtc ataacattta tgctaacgga gaaaaggctg aaaatcatga 929701 cgcacagtca aggaggagat agaagtggac ggagttaaat gccagtttgt caatacgaac 929761 ggaatcacgc ttcacgttgc agccgcagga cgggaagatg gcccgttaat tgtcctgctc 929821 catggatttc ctgagttttg gtacggctgg aaaaatcaaa tcaaaccgct tgttgatgcg 929881 ggttaccggg tcattgctcc tgatcagcgg ggctacaatc tcagtgacaa accggaagga 929941 attgattcgt atcggattga tacattaaga gatgatatca tcgggcttat tacgcaattc 930001 actgatgaaa aagcaattgt catcggtcat gactggggag gagctgtcgc atggcatttg 930061 gcttccacac gcccggaata tcttgaaaaa ctgatcgcga tcaatatccc gcacccgcac 930121 gtcatgaaaa ccgtaacgcc gctttatccg ccgcaatggc tgaaaagctc gtatatcgca 930181 tacttccagc tgcccgatat accggaggca tcactaaggg aaaatgatta tgatacatta 930241 gacaaagcga ttggattatc cgaccgtccc gcgcttttta catccgagga tgtcagcagg 930301 tacaaagaag cgtggaagca gccgggcgcg ctgacagcta tgctgaactg gtacagagcc 930361 ctcagaaaag gaagcttggc agagaaaccc tcttacgaaa cagtacctta ccgaatgatc 930421 tggggaatgg aagaccgctt tttgagcaga aagcttgcga aagagacgga aaggcattgc 930481 ccgaatggac atctcatctt tgttgatgaa gcttcccatt ggattaacca cgaaaagcca 930541 gccatcgtca atcagctgat tttggaatat cttaagaacc aataagctaa aatttctctc 930601 catccgtctg tcataatggc agactttttc tgtgcgtttt ttttcatagt ctgttttaaa 930661 catgacaaaa taacattaaa aatcatgaat gtcaccataa aattgtaaca aaaaacaggt 930721 ttaaacgact ttaaaaaaag gaatagcctt actgaagatt tgtgtaaaac tcccctaagg 930781 caatacttaa aaagaataat aaaaagaagg tgccttaatg aagcaaggat taatctcgat 930841 tattatcccg tcttacaatg aagggtataa tgttaaactc attcatgaat ctttaaaaaa 930901 ggaatttaaa aacattcatt atgactatga aatattcttc ataaacgacg gaagtgttga 930961 tgacacgctt cagcagatca aagacttggc agcgacgtgc agccgggtaa aatatatatc 931021 tttttctcga aactttggaa aagaagccgc aattttggcg ggctttgagc atgttcaggg 931081 cgaggcggtt attgtcatgg atgccgatct gcagcatccg acatatttgc tgaaggaatt 931141 tatcaaaggc tacgaagaag ggtatgacca agtcattgcc caaaggaaca gaaaagggga 931201 cagctttgtc cgctcactct tatcatctat gtattacaag ttcattaata aagcggtgga 931261 agtcgatttg cgtgacggtg tcggtgactt cagattgtta agccgccaag ctgtgaatgc 931321 acttttgaag ctgagcgaag gaaaccgctt ctcaaaaggc cttttttgct ggattggctt 931381 tgatcagaaa attgtatttt atgaaaatgt cgaacgaaaa aacggcacct ccaaatggtc 931441 gttcagcagt ctgtttaact acggaatgga cggcgtcgtt tcatttaatc ataagccgct 931501 gagattatgt ttttatacag gcattttcat cctgctgctt tccatcattt atatcattgc 931561 cacattcgtt aaaattctga ctaacggtat ttctgtgcct gggtatttca ccattatctc 931621 agcagtgtta tttctcggcg gagtacagct gttaagtctt ggaataatag gtgaatatat 931681 cggccgaatc tattatgaaa caaaaaaacg cccgcattat ttgatcaaag aggcgaatat 931741 cccgaacaaa gacctgcctg aaacgaacga attaaaaagc atgcggcgtc tgacaaaaat 931801 gcactgaaaa taccaagcgc cattggcagt gctttttttg cgtgtctatt atcttaaaag 931861 caagactgga gaattcatat gaaaagaaaa catatcatga tctatgcggc cagtttgctg 931921 gtgtccgttc tggcacacgc tttttttgtg aaagaatggg cggaaggcag gtatatgaca 931981 ggtccgggtg acgggcttgc gcaaatgatc gtatttaaaa aattattatt tgaccaatat 932041 acacacggga attttttcta caattattca ttcggacttg gcggcggcac attcagtcag 932101 ctcggctatt atttttctgc gtcttttctt tttcttgctg tgtctgccgc tgtttggctg 932161 cttcaagccg tccagctgat cggagaaacg gatacgcttt tttgggcaga gtcagctgtt 932221 tttatcagta ttttcaaatt gagcttgatc atctttacgt ccgcttctgt ttttcattat 932281 cttcttaagc acagggcggc atcgttcacg ggagccgtgt tatacggcgt ctcaattatt 932341 tatttccgtc acgaagcgta ttgggaattt ttcaccgata caatggtttg gcttccgctg 932401 cttgtgcttg gcgcagaaaa aattattaga gagcggcgtc cggcgtggtt tatcgttgcg 932461 tgttcgctga cgttaatcaa caatttttac tttgcataca taaaccttat attcatcgga 932521 atctatgtgc tgttcagatg gctgatccgt ttggaaccac atgaagagaa aagatggatt 932581 caaatcagat tatttctcgt ttcaggcttc atttcttttg gcatcagtgc ggcggcgttt 932641 gtgccggtag tatacggttt tttaaacaac ctgcgccctc catacagcca gaaaatagag 932701 tggctcaatt tcgatgataa tatcttattt tcgagccgga tcatcattgt gccggccgct 932761 tttctgctgt ttttgtttat tatttctttt tacaaaaacc gtgtgtttcg tctctttgcc 932821 gggttgagcc tgctgtttat tctgtttcat ttcagtccgt atgcggcaag cgtctttaac 932881 ggtttttccg ccccgcaaaa ccggtttgaa tatgttctgg cctttaccat tgcgggagca 932941 gctgcggctg gtttgtcaca gctgtctgaa ttgaaacgga aagaactgct cccggccgca 933001 gctgtcgtcc tgcttcttta cttgtatcat atccaaaggt ataagctcga tatatggaag 933061 cctgcgaatg aaagtattct attgctctta ctcatgacaa tcgcagcctt gtttgctgca 933121 gcttttgcga aaaaacgggc aaaaatggct gtgtacggta taatcattct ttcttcgctg 933181 tttgtcgcca actcctatca aaaatacgcg ctctcagaag gcggcgattt ggacagtgtg 933241 acaaaagaat atcttacaag tgaggaatac agagggcggg aatcatctga gctcatcaga 933301 cgtttacaga aggaagacga tgacccgctc atgagaatcg actggatgaa cggggtccgc 933361 aataatacgc caatcattta cggatttaat ggcttcagcg cgtattccag cattttaaac 933421 aaagatctgc tggccttcta ttggaatgat ttaagcatcg atatgggcag ggaaagcgtc 933481 agccgttacg cgtcattggg agacagggcg aatttataca gcctgcttta cggcaaatat 933541 tatatgaccg aaaaaacaaa cgaagccagc gtcccgtacg gcttcaaaaa gcatttagaa 933601 acagagcatt atgcagttta tgagaatcag tacatgcttc cattcgttaa aacagcggat 933661 gccatataca gcgaaagtga gctggaccga ttgcccgctc ttgcgaaaga acaggcgatg 933721 ctgaaaggaa ttatattaaa agatccatca ggaaaaacgg agcagacacc aaaaccgtcc 933781 aatttgatca ccaagtcgga catcaccgca aaacaagccc agtatcaaaa cgggctgcta 933841 accgtaactg gagaaaacgg aggagagctg atcatcaccc cgaaacagcc atcatccgct 933901 ccgggagact actatgtcag cttttatttg aaaagcaaag caaaagacaa aggatttaca 933961 ttaaaggtaa atgattatgt cacaacaagg aaatcgaaca aatcgatcta taaaaccgga 934021 gtaaataata taacggtaag agtgcctaaa tcaggccata tctcaatcaa tcttccgaaa 934081 ggaacctatg agctgagaaa catagcgctc tatgaagaaa attaccaaac gctgaaaaac 934141 gctgtaatgc aaaataaaac agagaaagca gacaaactga attggaacaa aaatcgactg 934201 accttttcct atcatctgtc aaaagaccag tacatcatgc ttccgatccc atatgaaaaa 934261 ggctgggagc tgaagatcaa cggaaaaaca cagaagatcg aaaaagcgga ttatgctttt 934321 ataggcttca aggcgcaaaa gggagacaat cacattgagc tgacttacta tccgccatac 934381 ttcaaaatat cggcgatcat atctctcgtc agtctgctgc ttgctgtttt ttatataaga 934441 cgtaaaaagc ccggctctat atagagccga gctttaattt tttctgaagt ttttcttcgc 934501 tgaatatcca tcccgtatag gatgaacgaa tcgtgagatc atggccgata tgaacaattg 934561 cgacaaacgg ataatggcct ttgctccgat aacgcaggtc gataaatctc acctcataat 934621 gatctttaaa cgtatccact tcccaccggt ataccggaga aaaggacaga aacgccgcga 934681 tgttatcatc ctgctttgcc gcatgcatta catcggtttc aggaacaggc acccgattaa 934741 atgtatccag aatcacgaca tgtccttcca tgcttcttcc tacatagaaa gcatgtgctg 934801 tcgtcactgc gattcgccat tgcctgaatt tcatcgttgg agaaataata atgctttcga 934861 tctcatcatg aatcatctca tgaagcttcc gtttaattct cagctgcatg atcaggcgca 934921 ccaagtagta gcctaccaat atgatatata agctgagaaa cgtgatgccg ggactcccgc 934981 ctgcatacca aatcgcgata gctgccagat ggctgataaa aataaacgga tcaaacgtat 935041 taatcagccc gagcgcaacc cattttttcg aaaacggacg aatggcttgt gttccatagg 935101 cgttgaatat atcaacaaag acatgcagaa cgactgccag cagtgtccac agccacaggt 935161 gcagaaaatc ggcctgagga taaaataaat acagaatcgc cgggatgatg acagaccaaa 935221 acaaaacggc gggaattgaa tgggtaaatc ctctgtgatt ccttatataa acagcattgt 935281 ttttaagctt taacacagta tcaatatccg gagcctgaga gcccgcaagc gttgcgatca 935341 taacagcgtg agccattgcc ggatctgatc cgacaacagg atcaagcgtc gcaataccgc 935401 ccagtgcgat gcccataacg acatgtgtgc ccgtatccat aggtgacctc cttgcagggt 935461 gatcctgcac attcactttg taagaaattc cccattttca tatacccaat ttttaaactg 935521 attcaatcgt tctcatatgt ttccgctttt tctttattac tatttaatgt aacatattat 935581 cgtactgtgc ccttagtgta caacaaaaaa cagtctaaag aaaagcgggg cgcgaaagac 935641 tggggagaaa cacatatgaa cgtacttgaa gacaaattaa aacaaaaaga catacagcaa 935701 tttcgcgatg atttaatctc atggtttgaa cgagagcagc gcgttttgcc gtggagagag 935761 gaccaagatc catataaggt gtgggtatct gaagtgatgc tgcagcaaac gagagtagag 935821 acagtgattc cttactttct ccggtttgta gaacaattcc cgacagtgga agcgctcgct 935881 gatgctgatg aagaaaaggt gctgaaagca tgggaagggc tcggctatta ttcgcgagtc 935941 agaaacctgc aaagcgcggt aaaagaagtg aaacaggaat acggcggcat tgttcctcca 936001 gacgagaaag attttggcgg gttaaaaggc gtcggccctt atacaaaggg agcggtgctc 936061 agcattgcct acaataaacc cattcccgcg gttgacggaa atgtgatgcg tgtcatgtcc 936121 aggattctat ctatttggga tgatattgcc aaaccaaaaa caagaacgat ctttgaagac 936181 gccatacgag cttttatttc caaagaaaaa ccatctgaat ttaatcaggg cttgatggag 936241 cttggagcct tgatctgtac gccaaaatca ccctcatgcc tgctttgccc ggttcagcag 936301 cattgctcag catttgaaga aggcactgaa cgggagcttc cggtaaaaag caaaaagaaa 936361 aagcccggga tcaaaaccat ggccgcgatc gtactgactg atgaagacgg acaagtgtat 936421 atccacaaac ggccgtctaa aggtttgctc gccaacctgt gggaattccc gaatcttgaa 936481 acacaaaaag ggatcaaaac tgagcgtgaa cagctcattg ctttcttaga aaacgaatat 936541 ggcatacaag ctgatatcag tgatctgcaa ggtgtagtcg agcatgtttt cacccacctg 936601 gtatggaata tttcagtgtt tttcggtaaa gtaaaacaag tgtcggatac cagcaagctg 936661 aaaaaagtaa cgaaagaaga gctcgaacaa tttgcgttcc cggtgtcaca tcaaaaaatc 936721 tggaagatgg caggagaagc agccgccatc tcggctgctc cgtaaaccat tcttaatcgt 936781 aagagacgcg cgtgccgtgg ctgtagtccg cttcattgcg cttcattccg ccgcgcgctt 936841 caatttcttg cgttaattcc cggtattttg attggccttc ttcgttcaaa taaggcataa 936901 tttgctgaaa ggcatgatga aaataagcga gttcactgtt cttccaatct tttttggaaa 936961 ccatgttcaa ttcgctcata tcacgtccga catacataac agaagacccc ctttaaagtt 937021 cttgccatta ttgtttgtgg aaataaaaga actatacgct acaaggagat gaggaaaaat 937081 ggaacaaaat aaatgtgcac tcgtaacagg aagcagccgc ggtgtcggaa aagcggccgc 937141 gatcagactt gctgagaacg gctataacat cgtcattaac tatgcacgca gcaaaaaagc 937201 agcattagaa acagcggaag aaatcgaaaa gcttggcgtt aaagtgcttg tcgtaaaagc 937261 aaacgtagga cagcctgcaa aaatcaaaga aatgtttcag caaattgatg aaacgttcgg 937321 cagacttgat gtttttgtca ataatgccgc ttcaggagta ctaagacctg tcatggaatt 937381 agaagaaaca cactgggact ggacgatgaa cattaatgcg aaagcattgc ttttctgcgc 937441 tcaggaagct gccaagctaa tggagaagaa cggtggcggg catattgtca gcattagttc 937501 attaggctct atccgctatc ttgaaaacta caccacggtc ggtgtatcaa aagcagcgtt 937561 agaggcttta acccgttatc ttgccgttga gctttcacca aaacaaatta tcgtcaatgc 937621 tgtttcaggc ggagcgatcg acacagatgc gctgaagcac ttcccgaata gagaagatct 937681 gcttgaggat gcgcgccaaa atacgccggc gggacgcatg gtcgaaatta aagacatggt 937741 tgatactgtg gagtttctag tgtcttccaa ggctgacatg atccgcggac agacaattat 937801 cgttgacggc ggacgctcac tgctcgttta aaaattttta aaaaagagga atagctatac 937861 gatcacctgc acattctaat gaccgtggag gtgataacaa tggctaactc aaataacttc 937921 agcaaaacaa acgctcaaca agttagaaaa caaaaccaac aatcagctgc tggtcaaggt 937981 caatttggca ctgaatttgc tagcgaaaca aacgctcagc aagtcagaaa acaaaaccag 938041 caatcagctg gacaacaagg tcaattcggc actgaattcg ctagtgaaac tgacgcacag 938101 caggtaagac agcaaaacca atctgctgaa caaaacaaac aacaaaacag ctaatcactg 938161 aaacagaaaa aagcacttca tcttcgggtg gaagtgcttt tttctgtttg aaaaacgaca 938221 aaacttgtgg aaggtctaca gaatgagtca aagggtttgc tttatggaga tcgaaatgat 938281 taaaggagga aatgtttata ctttcatcag gctgaaggag gaaccgatga ccgaatttga 938341 aaagctggta agtgaacaga tgaaaacgat ggataagctt ctcgatctcc aatcagagct 938401 cgaccgctgc aaacaaattg aggcggaact ccggcatttg gaaagggatg caaggctgcg 938461 tgggattcag gctgaaattg cggtaaaacg gaaacacctt gccgatatac aggatatgtt 938521 tcaaaagcag acagagcagg tcattcgttc atatcgcagc tcagaaaagc cgtcttcctt 938581 tgtgtagtgc aggaatgtgc cattccccgg ccggaatggc tcttttattt tcatttttca 938641 atttgtaacg ttataatagg taaaagacgt tgtcggtaag caaatttgga catactaact 938701 gtagggcttt atagaaagta ggggagaaat atgggctatc ccaaggaagg agaaaccatt 938761 caaattcaca gctataagca caacgggctg attcatagaa tttggaatga gacaacaatc 938821 ttaaaaagta cagaaatgtg tgtcatcgga gccaatgacc ggacgatggt aaccgaatca 938881 gacggccgga catggataac cagagagccc gcaatctgtt attttcacgc aagacaatgg 938941 tttaatgtca tcgggatgct gagggaagac ggggttcatt attattgcaa catcagttct 939001 ccgtttgcct atgatggcga agcaattaaa tatattgatt atgacttaga tgttaaggtt 939061 tttcctgaca tgacctacaa tattctcgat gaagacgaat atgatgatca tcggaaagcc 939121 atgaattatc caaaagaaat cgacagtatt ttaagagact acttaaatac gctgctccat 939181 tggattcacc agcgtcaggg accgtttgcg cccgagtttg tcgatatgtg gtatgaacgg 939241 tatttgcgct atacaaaata atggttacgt aaaaacctgt tgcggggtac aacaggtttt 939301 tcacatgggc tcacacacat catgataaag agagaggggg aatcaaccgt gggggttatg 939361 aaacgctaca tgcaattcgt caaaccttat aagaagcaaa ttttcgttac agtgttaatc 939421 gggatcgtaa aattctccat tccgcttgct ctcccattgc ttctgaagta cgtagttgac 939481 gacattattc aaggaggcgg cacggccagt gacaaaacca cgtcattgtt cacgattatg 939541 gcgatcatgt tcgccttatt tttaattttg cgcccgcctg ttgaatatta ccggcaatat 939601 tttgcccagt ggactgccag caaggtgctt tatgatataa gagctaagct gtttgaccat 939661 atacaaaaac tgagccttcg tttttacgcg aatacaagaa caggggaagt catttcccga 939721 gtgattaatg atgtagaaca aacaaaggat ttcgtcatca cagggctgat gaatatatgg 939781 ctcgatatgc tgacgatttt gattgtaatc tctatcatgc tcacactgga cgttaaatta 939841 acgctgatct ctatcgtttt attcccatta tacggaatat cagtgaagta tttttacggc 939901 cgtttacgaa agctgacaag ggagcgctca caggctcttg ctcaagtgca ggggcatttg 939961 catgaacgca ttcaaggcat gcctgtcatc agaagctttg cgatagaaga tcatgaacag 940021 gctcaattta atgagaaaaa cggtcatttc ttagataaag ccatccgcca cacgaattgg 940081 aacgcgaaaa cctttgcggt cgttaatacc attacagatt tggcgccgct catcgtcata 940141 gcgtgcgccg ggtattttgt cattaatgga ccgctgacag tcggaacaat ggtcgcgttt 940201 gtcggatata ttgacagaat gtacaaccct gttagaaggc tgatcaattc ctctacaact 940261 ttgacacagt caatcgcatc aatggacagg gtgtttgaat ttattgacga gccctatgaa 940321 ctcactgaca aaccaaatgc gataaaggcc gatcagattc gcggaggagt ggagtttcaa 940381 aacgtttcgt ttcaatatga gaaggacaaa gaaaatattc ttcatgatgt atccttaaaa 940441 gtaaatagag gagaaactgt agctctcgtc ggcatgagcg gaggaggaaa atcaacgctc 940501 gtcagcctga tcccaagatt ttatgatgta acaagcggca gactgctgat tgatgggacg 940561 gatattcgcg attatgaagc aagaagcctt cgcaaccagg ttggtatggt gcttcaagat 940621 acctttttat ttagtgaaac gattcgggaa aatatcgcga tcggcaagcc tgatgccaca 940681 cttgaagaga taatcgaagc cgccaaagct gcaaatgccc atgaatttat catgagtttt 940741 ccagaaggat atgagacccg ggtgggggaa cgaggcgtta agctttcagg cggacaaaag 940801 cagcggatct caattgcgcg ggtattcctg aaaaatccgc cgctcctcat tttagatgaa 940861 gctacatcag ctctggattt ggaaagtgag cattacattc aagaagcgat ggacaaactg 940921 gcgaaggata gaacaacttt tgttgtcgcc caccgtttat cgacaatcac ccatgcggat 940981 aagattgttg tcatggaaaa cgggacaatc attgaaatcg gaacccatga tgaactcatg 941041 gactatgaga gccaatacaa gcacttattt accattcaaa atttgaacta aaacatcaat 941101 cttatatcct tttaacgaag gatataagat ttttttgtat ataaaaaaac ccggctgttt 941161 aaccgggtta ctcttctgtt tctatttcgc agtctttcgg atgatacgtt tgaaaacttg 941221 tgataagtgt ttctaaatgt tcaagctgct cgcgatattc cacggcgctt gccataatat 941281 tgagcatgtt gtaatcaata agctcctcat ccgtattctg ctgatttttt aaaaatgact 941341 ttgttaaaag ctgcttatac cggatgcctt cttcaaccgc gtcatcatgc ggcttgattt 941401 ttccgacaaa cctcatcaaa atccgctcgt gccagtaaag caggtaatca agttcttcag 941461 tcaatgtttc ctgaaactct tccggcatat gatagatctc gttttccaga cgatgcagct 941521 tcttcaatgt atcaagcgcc cgatttgcag taataatggc ctgtctgaac aggacaagct 941581 ttcttgattt cacataagtc gttttcttaa agtaacttct ttcttcttta tatagaagat 941641 atgtctgatc aagcttgatc attttttctt tcagtttttc aatatcctct ttcaaaatcg 941701 aatgctctgt cgactgccgc atggacaatc tgatccactt cataatttct tcggtgtttt 941761 cgacggtatt atgaatcagc tttgtttcgt acttaggagg caaaaacaca aggttgacga 941821 taaaggaaga aagcacccct aagatgactg tgcttgttct gatcagcgcg aacattaaaa 941881 agtcgtcacc ggcagattct aatatcgcaa tgactgttac aagagcaatt gaaattgtat 941941 gttcaatttt aagtttcagc atgattgtaa tgacaataac tgctgttaac ccgatcataa 942001 tcgggctggg tccgaaaata aggccgaaca ctgtggcaat cacagctccg atgatatttg 942061 cttgaacctg gtcaataata atgagaaaag agcggtaaat cgacggctgg atcgcaaata 942121 tcgctgcaat tccagcgaaa atcggcgcgg gaagcccgat ccacgaagcc aaataaaggg 942181 caagtgtaat cgcaatcccg gttttgaaaa tgcgggcacc aagtttcatt ggtttgtgcg 942241 tgcattcctt tctatagtaa attgtgtgac atagcaaatg ggctaatcct taaaattccc 942301 ggttagttta tttgctaaac aattaagtaa tatacaggga tcgatacaaa tattcaagct 942361 atttttctag aaaaagacca aaatcttaca cgctgtttga ttccataaaa aaacaggagc 942421 tcaaagctcc tgttcaaggt atttgattct agttttttag atgtttaaat gcatcctcga 942481 ccgctgtaag cgtgtcttta atatcctgct ctgtatgtgc tgtggtaata aaccaagctt 942541 catacttaga aggtgctaaa ttaattccgc gttccagcat cagcttgaaa aacgtagaga 942601 atgtttctcc gtcactccgt tcagcctgct cgtaattttc cactttctca tcagagaagt 942661 ataccgtgag cgcacctttt aaccggttga ccgtaatggt gatgccgtgt gtttctgcgt 942721 gcttcaaaat gccttcctca agcatagcgc caaggtgatc aagcttttca tacacgcctt 942781 tttctttgag cacttccaga caagcgatgc ctgataggat ggaagcgggg ttccctgcca 942841 ttgttcctgc ctgataagca ggccctagcg gagctacctg ctccatgatt tcttgtttgc 942901 cgccataggc cccaatcgga agtccgccgc cgataatttt cccgagtgct gttaaatctg 942961 gtttcacctg taagagatcc tgcgcgccgc catacataaa gcggaaagcc gtaatgactt 943021 catcgtaaat aacgagagcc cctgcattat gtgttaattc atttacttgt tctaagaagc 943081 cctctttcgg ctccacgata ccgaagttgc cgacaatcgg ttcaacgaga accgccgcga 943141 tttcactgcc ccatttttca agagctgctt tatagctatc gatatcatta aatggtactg 943201 tgatcacttc gtttgcaatg cttttcggta caccggctga gtctggtgtg ccgagagtag 943261 acgggccgga gcctgcggcg acaagcacaa ggtccgaatg cccgtgatag cagcccgcaa 943321 atttaatgat ttttgtccgg cctgtatatg cgcgagccac gcggatggtc gtcataacgg 943381 cttctgtacc cgaattgacg aatcttactt tgtccatagc gggaatggct tctttgagca 943441 tttttgcaaa tgtaacctcg tgtttcgttg gtgttccata caatacaccg ttctctgctg 943501 cttttttaat cgcttctgta atatgcggat gggcatgtcc tgtaataatc ggaccgtacg 943561 ccgctaaata atcgatgtat ttgttgccgt ccacatccca aaaataagcg ccgcttgctt 943621 tctccattgc aacaggagaa ccgccgccga ctgctttata tgatctagac gggctgttta 943681 caccgccgac aatgtgctgt aatgcctcat tgtgaagttc aattgatttt gtatgcaaga 943741 ataaaaacct cctatatctc catgcgtcct ttctattgta gcatgcttcc gaacaagaac 943801 aatggcttcg ggcttcagat tcagctgaga tggttgtaat ctggacaaga attggatacg 943861 cttaataaaa aaacatccgg aggtaacgta atgactatag aaatcggaca aaaagcgcct 943921 gatcttgagt taaaaggtga tcatggggaa acagtaaaat tatcggatta taaaggaaag 943981 tacatcgtgc tttattttta tccaaaggac atgacaccgg gatgtacaac tgaagcatgc 944041 gattttcggg acagtcacga aagcttcgcc gaactggatg ccgtcattat cggcgtcagc 944101 ccggacagcc aggaaaaaca cggaaaattt aaagagaagc ataaccttcc atttctgctt 944161 cttgttgatg acgagcataa gctggcggaa gcatttgatg tgtggaagct gaagaaaaac 944221 ttcggaaaag agtatatggg aatcgagcgt tccacttttt taattgataa agaaggccgg 944281 ctcattaaag aatggagaaa agtaaaagta aaggaccatg tagccgaagc gcttcaaacc 944341 ctcaaagata tgtctgaaaa gtaaatctct atgagcctat gcttactttt accctgatat 944401 caattgacaa attatcgtag aaagagttac actaattata aacattacaa tgtaagaatt 944461 ttttttagaa gagaggtgca tgacggatgg ctgcacatga actaaaagaa gccttagaaa 944521 cgttgaagga aaccggagtt cgcattactc ctcaacgtca tgcgattctg gaatatctcg 944581 ttaactctat ggctcatcca acagcggacg atatatataa agctctggaa gggaaatttc 944641 ctaacatgag cgtagcgacg gtatataaca atttgcgtgt gttccgggaa tcaggtttgg 944701 taaaagagct cacatacggt gatgcttcca gcagattcga ttttgtcaca tccgatcact 944761 atcacgcgat ttgcgaaaac tgcggtaaaa ttgtggactt ccactacccg ggccttgatg 944821 aagtggagca gctcgctgcc cacgtcacgg gcttcaaggt aagccaccac cgtttagaaa 944881 tttacggcgt ctgccaagag tgttcgaaaa aagaaaatca ttaaaaataa gctgaccgca 944941 cgaaacggtc agcttatttt atttcgacat tttcttttta ttataagact catcaaattc 945001 ttttccttct aatcccttat ctaaagtcag cggctctcgg caatgcatgc acatatcgac 945061 tactcctaaa acctttgtct ctttatcaca gcctggacaa atgacgcgaa ccgctttagt 945121 cgaaagcatt ccgatccaaa agtaaactac cgtgctgaga ccgatggata aaagcccaag 945181 tatcataaac aaactagaaa gcaaaactga ctctttgaaa aagatcccga tgtacataat 945241 gataaaccca acgaaaacca aacttaacgc aaatgttctg attttattaa ttttgctgga 945301 gtatttcgcc atgtccatcc ccctctgttt taactatagc acaaacccga tgggattttc 945361 ttcatgtttt cggttgaact ggaatttaca tatggagagt tactgtgaaa ttgtttataa 945421 tagttcaatg tgtttagaaa aaaggaattt cgttttaacc atagaattga atcaaataga 945481 gaataaaaaa atttgaacaa ttgcattgga ggaatagtga tggaaaatct tctccgtcca 945541 atttaccaag aaagagcaag tcaccccaat acattggctg tcattatgat tgagagaaga 945601 aacaaaacat cttccttaac agataacttt gatgcagctt tgctggtgat tgtaaaggat 945661 gctgatgagc cagtttttat aaagcattat gaatttgatc atcaaacagc ttctttgcat 945721 gtggtaacag attctcagat tcaagaatgg attttgcttg gaacaaatag aagaatcata 945781 gattggattg taaatggcag agtcttgttt gaccgtaatg aatacgtagt tgaactgatt 945841 gacaggctga atacatttcc gtttgccgaa cgtaaactga agatcggact cgaatacggc 945901 aaattaatca gaaggtatgt tgaagggaaa gctttttttg aagccaatca atttttagat 945961 gcctacaatg ccgttgttca tgcgctgcat catttagcac gtattgaagt aatcgacaga 946021 ggattccatc ccgaaaccac ggtgtggagc caagtgcgcc agatggagcc ccaagtgtac 946081 aaattatatt ccgagctgat tgaaagtcat gagagcctgg aaaaaagact tgaattatta 946141 ttcttagcaa atgattttct catccattcc aaagccgaga tcggttcggc gcatcttttc 946201 gaagtaatga aagaaaaaga catttggcaa ttcggtgagc ttcttcaaca tcatgaccta 946261 aagcacttta cccaagatct tggcgttatg cttgattact tgacggaaaa gggacttatc 946321 aacgtctgcc agatagaaac gaaaggacag gctgtctatc accgaggata ttcttttaaa 946381 aaaggtgttg actctgattc ttgaccgtgt tatattatta aacgtcgctg atgcgcttct 946441 gagaaaacaa gctcacagcg gcgggaaaat aaatcaaaaa aacatttgac aaaagaaagt 946501 caaaatgtta tattaataaa gtcgcttcaa caagaagtga aaatgatctt tgaaaactaa 946561 acaagacaaa acgtacctgt taattcagtt tttaaaaaat cgcacagcga tgtgcgtagt 946621 cagtcaaact agggcctgca cgacgcaggt cacacaggtg tcgccgcagg atgcggtgaa 946681 cttaacctgt gatccattta tcggagagtt tgatcctggc tcaggacgaa cgctggcggc 946741 gtgcctaata catgcaagtc gagcggacag atgggagctt gctccctgat gttagcggcg 946801 gacgggtgag taacacgtgg gtaacctgcc tgtaagactg ggataactcc gggaaaccgg 946861 ggctaatacc ggatggttgt ttgaaccgca tggttcaaac ataaaaggtg gcttcggcta 946921 ccacttacag atggacccgc ggcgcattag ctagttggtg aggtaacggc tcaccaaggc 946981 aacgatgcgt agccgacctg agagggtgat cggccacact gggactgaga cacggcccag 947041 actcctacgg gaggcagcag tagggaatct tccgcaatgg acgaaagtct gacggagcaa 947101 cgccgcgtga gtgatgaagg ttttcggatc gtaaagctct gttgttaggg aagaacaagt 947161 accgttcgaa tagggcggta ccttgacggt acctaaccag aaagccacgg ctaactacgt 947221 gccagcagcc gcggtaatac gtaggtggca agcgttgtcc ggaattattg ggcgtaaagg 947281 gctcgcaggc ggtttcttaa gtctgatgtg aaagcccccg gctcaaccgg ggagggtcat 947341 tggaaactgg ggaacttgag tgcagaagag gagagtggaa ttccacgtgt agcggtgaaa 947401 tgcgtagaga tgtggaggaa caccagtggc gaaggcgact ctctggtctg taactgacgc 947461 tgaggagcga aagcgtgggg agcgaacagg attagatacc ctggtagtcc acgccgtaaa 947521 cgatgagtgc taagtgttag ggggtttccg ccccttagtg ctgcagctaa cgcattaagc 947581 actccgcctg gggagtacgg tcgcaagact gaaactcaaa ggaattgacg ggggcccgca 947641 caagcggtgg agcatgtggt ttaattcgaa gcaacgcgaa gaaccttacc aggtcttgac 947701 atcctctgac aatcctagag ataggacgtc cccttcgggg gcagagtgac aggtggtgca 947761 tggttgtcgt cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga gcgcaaccct 947821 tgatcttagt tgccagcatt cagttgggca ctctaaggtg actgccggtg acaaaccgga 947881 ggaaggtggg gatgacgtca aatcatcatg ccccttatga cctgggctac acacgtgcta 947941 caatggacag aacaaagggc agcgaaaccg cgaggttaag ccaatcccac aaatctgttc 948001 tcagttcgga tcgcagtctg caactcgact gcgtgaagct ggaatcgcta gtaatcgcgg 948061 atcagcatgc cgcggtgaat acgttcccgg gccttgtaca caccgcccgt cacaccacga 948121 gagtttgtaa cacccgaagt cggtgaggta accttttagg agccagccgc cgaaggtggg 948181 acagatgatt ggggtgaagt cgtaacaagg tagccgtatc ggaaggtgcg gctggatcac 948241 ctcctttcta aggatattat acggaatata agaccttggg tcttataaac agaacgttcc 948301 ctgtcttgtt tagttttgaa ggatcattcc ttcgaaacgt gttctttgaa aactagataa 948361 cagtagacat cacattcaat tagtaataca agatatcaca tagtgattct ttttaacggt 948421 taagttagaa agggcgcacg gtggatgcct tggcactagg agccgatgaa ggacgggacg 948481 aacaccgata tgcttcgggg agctgtaagc aagctttgat ccggagattt ccgaatgggg 948541 aaacccacca ctcgtaatgg agtggtatcc atatctgaat tcataggata tgagaaggca 948601 gacccgggga actgaaacat ctaagtaccc ggaggaagag aaagcaaatg cgattccctg 948661 agtagcggcg agcgaaacgg gattagccca aaccaagagg cttgcctctt ggggttgtag 948721 gacactctgt acggagttac aaaagaacga ggtagatgaa gaggtctgga aaggcccgcc 948781 ataggaggta acagccctgt agtcaaaact tcgttctctc ctgagtggat cctgagtacg 948841 gcggaacacg tgaaattccg tcggaatccg ggaggaccat ctcccaaggc taaatactcc 948901 ctagtgaccg atagtgaacc agtaccgtga gggaaaggtg aaaagcaccc cggaagggga 948961 gtgaaagaga tcctgaaacc gtgtgcctac aagtagtcag agcccgttaa cgggtgatgg 949021 cgtgcctttt gtagaatgaa ccggcgagtt acgatcccgt gcaaggttaa gcagaagatg 949081 cggagccgca gcgaaagcga gtctgaatag ggcgcatgag tacgtggtcg tagacccgaa 949141 accaggtgat ctacccatgt ccagggtgaa gttcaggtaa cactgaatgg aggcccgaac 949201 ccacgcacgt tgaaaagtgc ggggatgagg tgtgggtagg ggtgaaatgc caatcgaacc 949261 tggagatagc tggttctctc cgaaatagct ttagggctag cctcaaggta agagtcttgg 949321 aggtagagca ctgattggac taggggcccc taccgggtta ccgaattcag tcaaactccg 949381 aatgccaatg acttatcctt gggagtcaga ctgcgagtga taagatccgt agtcgaaagg 949441 gaaacagccc agaccgccag ctaaggtccc aaagtatacg ttaagtggaa aaggatgtgg 949501 agttgcttag acaaccagga tgttggctta gaagcagcca ccatttaaag agtgcgtaat 949561 agctcactgg tcgagtgact ctgcgccgaa aatgtaccgg ggctaaacgt atcaccgaag 949621 ctgcggactg ttcttcgaac agtggtagga gagcgttcta agggctgtga agccagaccg 949681 gaaggactgg tggagcgctt agaagtgaga atgccggtat gagtagcgaa agaggggtga 949741 gaatcccctc caccgaatgc ctaaggtttc ctgaggaagg ctcgtccgct cagggttagt 949801 cgggacctaa gccgaggccg aaaggcgtag gcgatggaca acaggttgat attcctgtac 949861 cacctcctca ccatttgagc aatgggggga cgcaggagga tagggtaagc gcggtattgg 949921 atatccgcgt ccaagcagtt aggctgggaa ataggcaaat ccgtttccca taaggctgag 949981 ctgtgatggc gagcgaaata tagtagcgaa gttcctgatt ccacactgcc aagaaaagcc 950041 tctagcgagg tgagaggtgc ccgtaccgca aaccgacaca ggtaggcgag gagagaatcc 950101 taaggtgatc gagagaactc tcgttaagga actcggcaaa atgaccccgt aacttcggga 950161 gaaggggtgc tctgttaggg tgcaagcccg agagagccgc agtgaatagg cccaggcgac 950221 tgtttagcaa aaacacaggt ctctgcgaag ccgtaaggcg aagtataggg gctgacgcct 950281 gcccggtgct ggaaggttaa gaggagcgct tagcgtaagc gaaggtgcga attgaagccc 950341 cagtaaacgg cggccgtaac tataacggtc ctaaggtagc gaaattcctt gtcgggtaag 950401 ttccgacccg cacgaaaggc gcaacgatct gggcactgtc tcaacgagag actcggtgaa 950461 attatagtac ctgtgaagat gcaggttacc cgcgacagga cggaaagacc ccgtggagct 950521 ttactgcagc ctgatattga atgttggtac agcttgtaca ggataggtag gagccttgga 950581 aaccggagcg ccagcttcgg tggaggcatc ggtgggatac taccctggct gtattgacct 950641 tctaacccgc cgcccttatc gggcggggag acagtgtcag gtgggcagtt tgactggggc 950701 ggtcgcctcc taaaaggtaa cggaggcgcc caaaggttcc ctcagaatgg ttggaaatca 950761 ttcgcagagt gtaaaggcac aagggagctt gactgcgaga cctacaagtc gagcagggac 950821 gaaagtcggg cttagtgatc cggtggttcc gcatggaagg gccatcgctc aacggataaa 950881 agctaccccg gggataacag gcttatctcc cccaagagtc cacatcgacg gggaggtttg 950941 gcacctcgat gtcggctcat cgcatcctgg ggctgtagtc ggtcccaagg gttgggctgt 951001 tcgcccatta aagcggtacg cgagctgggt tcagaacgtc gtgagacagt tcggtcccta 951061 tccgtcgcgg gcgcaggaaa tttgagagga gctgtcctta gtacgagagg accgggatgg 951121 acgcaccgct ggtgtaccag ttgttctgcc aagggcatcg ctgggtagct atgtgcggac 951181 gggataagtg ctgaaagcat ctaagcatga agcccccctc aagatgagat ttcccattcc 951241 gcaaggaagt aagatccctg aaagatgatc aggttgatag gtctgaggtg gaagtgtggc 951301 gacacatgga gctgacagat actaatcgat cgagggctta accatatttt tgaatgatgt 951361 cacacctgtt atctagtttt gagagaataa gtttttcaaa aaaacacttg attttctcaa 951421 gaatacatag tataatgtta aatgtcactg aaattgtctg gtgatgatgg cgaagaggtc 951481 acacccgttc ccatgccgaa cacggaagtt aagctcttca gcgccgatgg tagtcggggg 951541 tttccccctg tgagagtagg acatcgccag gcagacttca ttccgcagta gctcagtggt 951601 agagctatcg gctgttaacc gatcggtcgt aggttcgaat cctacctgcg gagccattat 951661 tggagagctg tccgagtggt cgaaggagca cgattggaaa tcgtgtaggc ggtcaactcc 951721 gtctcaaggg ttcgaatccc ttgctctccg ccactgatac ttatacataa ttacaattga 951781 aagtctgggc ccgttggtca agcggttaag acaccgccct ttcacggcgg taacacgggt 951841 tcgaatcccg tacgggtcat tatatgatgg aggattagct cagctgggag agcatctgcc 951901 ttacaagcag agggtcggcg gttcgagccc gtcatcctcc accattatat catcgcgggg 951961 tggagcagtt cggtagctcg tcgggctcat aacccgaagg tcgcaggttc aaatcctgcc 952021 cccgcaacca aattttaaaa tggtccggta gttcagttgg ttagaatgcc tgcctgtcac 952081 gcaggaggtc gcgggttcga gtcccgtccg gaccgccatt tgaatactta ggctcggtag 952141 ctcagttggt agagcaacgg actgaaaatc cgtgtgtcgg cggttcgatt ccgtcccgag 952201 ccaccaccta tgccggtgta gctcaattgg tagagcaact gacttgtaat cagtaggttg 952261 ggggttcaag tcctcttgcc ggcactgttt tttcaaaatt taatgtggag gggtagcgaa 952321 gtggctaaac gcggcggact gtaaatccgc tccctcaggg ttcggcagtt cgaatctgcc 952381 cccctccacc atttataggg gcatagttta acggtagaac agaggtctcc aaaacctccg 952441 gtgtgggttc gattcctact gcccctgcca aatttatgac atcttgagat tatggcggtt 952501 gtggcgaagt ggttaacgca ccagattgtg gctctggcac tcgtgggttc gattcccatc 952561 aatcgcccca tattatcatt gggctatagc caagcggtaa ggcaacggac tttgactccg 952621 tcatgcgttg gttcgaatcc agctagccca gtctcacttt ttatatcaac tgcatataat 952681 gtattaagtc cattaaaaat gcggaagtag ttcagtggta gaacaccacc ttgccaaggt 952741 gggggtcgcg ggttcgaatc ccgtcttccg ctccaattac ggcggcatag ccaagtggta 952801 aggcagaggt ctgcaaaacc tttatccccg gttcgaatcc gggtgtcgcc ttcttattgc 952861 cggggtggtg gaattggcag acacacagga cttaaaatcc tgcggtaggt gactaccgtg 952921 ccggttcaag tccggccctc ggcaccaatt ttacttacat ggtaagttga attggtgttt 952981 gtgttttatc attataacta atcatattaa tgatctacat aagtagatca tttttttaat 953041 gctttgattt atcataacaa gttaagttcc gaggcctatt ataaagcggc tgtatagcta 953101 gtctttcaac acttttattt tatatttcca taaaaacttt tttgaaatac gttgacactt 953161 tatgagatcc atgatatatt tatattcgtc ggttagatac gacgtaaaac ttgccggtgt 953221 ggcggaattg gcagacgcgc acgactcaaa atcgtgttcc ttctggagtg tcggttcgac 953281 cccgaccacc ggtatactga aaaacccgtt tcttaacaga aacgggtttt tattttttat 953341 taaagaaaag gagcctcggc tcctttttat acttactcag cgtattggtc taggatctct 953401 tctagcacct cttctagctc ttctgtatct tcaagctctg attggctgaa acggacgcgt 953461 acaagctgtt ctccgtcatt atacatctct tccaaccacc ctcggagtcc tcttgctctg 953521 cggtcgactt cgaaaatgat ttccaaaccg tcttcgtcta aaaggaaaat gagctctaat 953581 tcatcaagca tctgacgata atatccggaa gtcggaacga attcgaattc ttgaacgaac 953641 ggaagacgac gctggaagta gggcgcttgt tcgcagtctg cttcgttaag acggaagccc 953701 aggttttcga ttgcttcaag cacattttca atccaagggt gcgcttcaac gaaaatgcgg 953761 tcatgatcgg atttatcgat accgccttga atgtcaaggt ctgtcaccac ggcaacctct 953821 actttcccta cagtgatcgg cgtatctaga ggcagagtga atgtgaacgg aaattgatgc 953881 tcttcaccag gctgtatggt aaatgaacca gtgacccgga aagaatgaat tgtagcgtat 953941 ttccggtgct cttcatcgtc ttttacaatg acataccgtg tgctaagctg taaatcgata 954001 taacggatgt cctgagcgat ttttccgcct ttgacatgta ccgttccctg tacttcttct 954061 cctggaaaat atgcgtcttt ttctaaaatt gtatctactt ttgcagctcc aattccggca 954121 cttgccgcaa gcttcttaaa aaatgacatg ttagatcttc ccctttttct tttttctcaa 954181 cagatatacg taagaaggag gaaaaaagat tcgtttgatt catacttttt tcctattatt 954241 cgtctcggcc tagggacaga ctaagaataa tattgaaaat aaaggagtcg atggaagtga 954301 ataaagaaag tttggttgca gatgaattac acagaatgtt tttggctggt gagctgcaaa 954361 tcacagtaga ggaggatata aacaatattt ccgaaaggct gagaaacggc gatctcagtt 954421 tagaccgatt aagcggtgaa gacgtgttta taaaagaaac ggtaaatgag gctttaagaa 954481 gagtggagca ataaaaaaga gacggcatct catctttgag atcccgtctc tttttgtggt 954541 ctttgctgta agataaaagc gaatcgattt ggaattgctc acccgagcca ccccttttct 954601 aacagaagat ctgacagttc atcatggaga taaacagctg tatctaattg atcatgcaat 954661 gctcttctga tgtggggatt ttcggttgct gttgttgcga cagtgtattt gttaatgctg 954721 gtttttattg ttgttaacaa atcaagaata tctttgggac aaagactttg ttcaatggga 954781 aaccacctcc tttgtttttt tagcagctcc tgataagaaa gtatttgact ttgtttcttg 954841 cttctataca aaatgctata ataagcaaca aattttgttg gggggtgtga tgatgaagca 954901 gattattgcg atggggggcg ggggtttttc gatggagccg gataatttgt ccctcgatca 954961 atatatcctc aatcaatcaa aacgagagca gcctcgtatt tgttttttgc cgacggcgag 955021 cggagattcc caaaactata ttcagcggtt ttatcatgca tttcaaacat tggattgcgt 955081 gccgtctcat ttatctttgt ttaagccacc atcatcagat ttagtttctt ttgttatgga 955141 aatggacgtg atttatgttg gcgggggaaa tacgcggaat ttacttgtgt tatggaaaga 955201 gtgggggctg gaccatattc tcagggaagc atggaagaac ggtgtggttg tagctggaat 955261 aagtgccggt gcgatctgct ggtttgaaga aggggtgaca gattcagccg gaccgctgac 955321 aagtttgaaa agtttaggtt ttttgcaagg gagcttttgt ccccattatg acggggaaaa 955381 ggatcggaga ccggcatacc accagctgat atctaacaag ttcttatgca gtggctatgc 955441 agcggatgat ggggctgctc tccatttcat aaatgatcag ctgtttcaga ctgtgagttc 955501 aaggtcgggt gcaaaggcat atcgggtgat gatggctgaa catgaaatag ctgaaatccc 955561 gttgccggtc aaatatttag ggtgaaattg gctgaatatt atctatattc ctcttttttt 955621 cagattgatt ttatgataag atgagtgcga aatcaatagt tactgggggt gcccgctttc 955681 gggctgagag agaaggcaag cttcttaacc ctttggacct gatctggttc gtaccagcgt 955741 ggggaagtag aggaattgtt tttgttattg tcttgctggg caataatatg tttctttctg 955801 actgtaaccg ggttcattta tatgaatccg gttttttgtg ctggttatgg gcttgatttt 955861 gtcctttcaa acgtagaaag gggaaggaaa agtaatgcaa aacaattcag tgcagcaagc 955921 caacatttcc attatgtcaa gtttttcagg cagcaagaag gtatacgtgg agggttcttc 955981 ttcggacatc caagtgccga tgagggagat tgcattgagt ccgacgacgg gatcgttcgg 956041 cgaagaggaa aacgcgcctg tgcgtgtcta tgatacaagc ggaccgtata cggaccctga 956101 agtaaccatt aatattcaag aaggattaaa gccgctccgc caaaaatgga tcacagagcg 956161 cggtgacgtg gaagagtatg aaggtcgggc tataaaacca gaagataacg gttataaaaa 956221 agcaaaacca aacgtaagct atccaggatt aaagcggaaa ccgctgaggg cgaaggcagg 956281 tcaaaatgtc acacaaatgc actatgcaaa aaaggggatc attacacctg agatggaatt 956341 tatcgccatt cgtgagcatg tgtctcctga attcgtcaga gacgaggtag ccagcggccg 956401 ggcgattatt ccttcaaaca ttaatcaccc tgaaagtgag ccaatgatta tcggccggaa 956461 ttttcatgtg aagattaatg caaatatcgg gaattcagcg gttacgtcat ccattgaaga 956521 agaagtggaa aaaatgacgt gggccatccg ctggggagcg gatacgatga tggatctctc 956581 taccggaaaa gatattcata cgacgcgtga atggattatc cgcaattgcc ccgtgcctgt 956641 gggaactgtt ccgatttatc aggcgcttga aaaagtaaac ggcgtagctg aggatttaac 956701 gtgggagatt tatcgtgata cgctaatcga gcaggcagag cagggagtgg attattttac 956761 gattcacgcg ggtgttttgc ttaggtatgt accgctgact gccaaacgga caactggtat 956821 cgtgtcacgc gggggagcga ttatggcgca gtggtgtctg gctcatcatc aagaaagctt 956881 tttatacaca cattttgaag aaatatgtga gattatgaaa atgtatgata ttgctttctc 956941 tcttggggat ggtttgcgtc ccggatcaat tgctgatgcc aatgacgaag cgcagtttgc 957001 tgaattagag acgcttggag agctgacgca aattgcctgg aagcatgatg ttcaggtgat 957061 gattgagggt cctggacatg ttccgatgca taaaatcaaa gagaacgtcg ataaacaaat 957121 ggacatttgt aaagaagcgc ctttttacac attggggccg ttgacaacgg atattgctcc 957181 gggatatgac catattactt cagcgatcgg agcggcgatg atcggttggt acgggacagc 957241 aatgctttgt tatgtaacgc cgaaggagca tttggggctg ccaaaccgtg atgatgttcg 957301 tgaaggagtc attacatata agatcgctgc gcacgctgcg gaccttgcaa aagggcatcc 957361 cggagcgcaa atccgggatg atgcgttatc gaaagcccgt tttgaattcc gctggcggga 957421 tcagtttaat ttatctcttg atccggagag agcccttgaa taccatgatg aaaccctgcc 957481 tgctgaagga gcaaaaaccg ctcacttttg ttccatgtgc ggtccgaaat tttgcagcat 957541 gagaatttca caggatattc gggattatgc gaagaaaaac gatctcagtg aagcagaagc 957601 cataaataaa ggattaaaag aaaaagcaaa agagtttgtc gatacgggaa gcaatttata 957661 tcaataaaaa aaatgaagat ggagaatgct ccatcttcat ttttttagaa aaacagagag 957721 cgtcgaagcg gaggaatact ctgttcaaag cggaaaacat tttctggatc atatgtcgtt 957781 ttgacacggc ggagtcgttc aacgttttcg ccgtaatatg ttcttggcca gtttctgatt 957841 tcgatatctg gccaatttac gtagtctccc atcgtttctt tcgaaaggga cgttctcagc 957901 ccctcaatcc agcggacatt ttgtcttttt tctccagggg atgtccagtt tgttaagtat 957961 tcctgggcga tgattgcgtc acgataataa aatgccgttt ggtcgggagc gacccgtccg 958021 gctgccccgc cgagtgcttg ctgccagaca ctggcgtttt gattcggagc gtgctctaaa 958081 aagtgtttta ttgttgagat cgcacgttct gataatggct tttcaatgaa agagccggag 958141 cgtttcattt tttgaggctg attgcctccc gggctgttaa aaaaggttac cgcttcaatg 958201 aatggcgttg tttttaccat tccgcttgtc ggacttcctg ctttcaataa aggctttaac 958261 agttttttta actctgtttt tggcccgaca aattggccga gggcttctat gcggtttact 958321 tctttaggcc aaaactctat tgatgatgta agccggtcat ctgtatacgg ggcccagttc 958381 tgccacgtgt tatatacttc ctcaaaatca tcccatcccc atgtaataga aaaaatcgac 958441 acttgagaga tgggcactgc tttaaatgtc atggaggtga ctatgccgaa attgcctcct 958501 ccgcctccct gagacgccca aaataagtct ggatgatttg aacagctgac tgtaatcaga 958561 tcagcgccct ctttttcgtc tgctacgatc atctcaagct gcacgaggct gtcgcaagta 958621 agaccggcag cccttgttaa aagtccaatt ccccctccga gagttaaacc tgtgagccct 958681 acattagcaa tggtgcctgc gggaagcgtc aggccgtatt gccagagtgt ccgatagact 958741 tctcccaatt cagcccccgc ttcaatatag gccagctttt tatcctgatt cacagttatt 958801 tttttcatct cgcttaaatc aataacaaga ccgttattta aaagggaaaa gttctcatag 958861 ctgtgtctgc cgcctctaat acggaaaggc acacggtttt cacgcgccca tttcagcgca 958921 ttgagtgcat cctgtttgtt ttggcaaaac acaatgatgt caggatacct ttctaagctt 958981 aggttaatat tggttcttgc ttcgttatag tccggatcat cccgtgtcac gatacgtccg 959041 gtcaattttg tcttttccac actcccacat ctctttctct cgtattctag tttctctagc 959101 ttatgcgtca ggggaaaaga gtgtataagg aaaaagcggg gatgcaatct gatacagtgt 959161 caacaccctc aaaaaatagt tgacaggtcg gtattgtatg aattaacatg gtcagtacaa 959221 atttttcaaa tttatcgcgc tgatcggaac accgaaggct cttatcgttt agataagggc 959281 cttttttgta tgaaaaaggg gggattattg atgggagtca aaaaagaaaa ggggagaaaa 959341 cgattcagga agcgaaaaac ctacgggaat cagattttgc cgcttgagct gctgattgaa 959401 aaaaacaaac gagagattat aaacagcgcg gaactcatgg aagaaattta tatgaagatt 959461 gatgagaagc atacgcaatg tgtaactaaa tataaaaaaa cccgctgact acaacgggtt 959521 tttgcatttc tccattaaga atctttttta atcggcaatc caaggccttc tgccacgcgt 959581 tttccgtatt caggatccgc tttgtagaag tgctcgattt ggcgcagctt gatttcttct 959641 ttttctaccg gcttcatggc attaacgata ttttcaacaa ggcgggtacg ttcatcttca 959701 ctcattaaac gatacagatc gccggcttga gtgtagtgat cgtagtgatc gtagcttacg 959761 ctgtcagcga taccttgtac cggatatgct gcttgcttat cctcaggtga ctcttttgga 959821 ccgccgaagc tgttaggctc gtaatacaca gatccgccgc cgttatcatc aaaacgcatt 959881 tgcccatcac gctgataatt gtttactttg ttgcgtgcgc ggttgattgg cagcgcttga 959941 tggtttgcac cgacacggta gcggtgtgca tcatgataag caaaaagtcg accttgaagc 960001 attttatccg gtgaaacatc aataccaggc acgagggttc caggtgaaaa tgtcgcttgt 960061 tctacctctg caaagtagtt ttccggattt ctgtctagaa ccatgcgtcc gacctcgatt 960121 aacgggtagt ctttttgaga ccaaactttt gtgacatcaa acggatcgaa acggtacgta 960181 tttgcatctt ctaaaggcat gatttgcaca tatagtttcc atgcaggata atcaccgttt 960241 tcgattgcgt tgaaaaggtc ttctgtatgg taatcagggt tttcaccggc aatttttgct 960301 gccgtattga catcaaggtt tttcacgcct tgttctgttt taaagtgata tttaatccat 960361 acgccttcgc cttcggcatt tgtccatttg aatgtatggc ttccgaagcc gtgcatgtgg 960421 cgaagtgtcg caggaattcc gcggtcagac atcaggattg tcacttggtg cagtgactct 960481 ggtgaaagtg accagaaatc ccatacagcc gtagggtttt tcaggtgtgt ttttggatct 960541 cttttttgtg tatggatgaa atcagggaac ttaatcgcat cgcggataaa gaatacaggc 960601 gtattgttgc cgacgatgtc gtagtttcct tcttcagtat aaaatttaac agcaaatccg 960661 cgcgggtcgc gaactgtgtc agcagagcca agttcaccgg caactgttga gaaacggatg 960721 aacaacggtg tgcgtttgcc gacttcagaa aggaaagcgg ctttcgtgta ttttgttacg 960781 tcgtttgtca cttcaaaata tccgtgtgcg cctgctcctt tggcgtgaac aacacgttca 960841 ggaacacgtt ctcggttgaa atgggccaat ttttcgagta aatgtacatc ttgaattaaa 960901 gttggtccgc gagaaccggc agtcattgag ttttgattat ctccaaccgg agcgccccag 960961 ctagttgtca gtttatttga actcatgtta tcacctcttg gaatttataa gaacataata 961021 tcatctctaa gtaaaaagtc aatattattt tataattatt ataaaatagt tatctctatt 961081 aatcgatata tagtatcgaa attgttgaaa aaccttgttg taacagcttt ttatgacact 961141 taataatttt tggagaaata atttttcctt ctctatttgc gaaacaagca gagtaagtga 961201 taaacaagga tatcaaaaat cgtatttaaa aaagagttga catatcggaa taatttgaat 961261 taacatgtta ttcaaacaaa aaaacaattg ggcagctgat cggaccgccg aaggctctca 961321 tctctacaag aacagagatg ggggcctttt tgtttttttt gaaggcgggg ttggcagaaa 961381 gagagggata aaagtggctg tgaccatcag catcaaagaa aaggcatttg ttcaagaagg 961441 ccgcaaaaac acggtcttag aaaacataga attatcaatc gcaccaggcg aatttctaac 961501 gcttatcgga ccgagcgggt gcggaaaaag caccctgtta aagattattg cagggcttga 961561 ttctgaatat gacgggagtg tggaaattaa cggccgcagc gtaacagctc cgggtattca 961621 gcaaggattt atttttcagg aacaccgcct ctttccttgg ctgactgttg agcagaatat 961681 tgcagccgac ttgaatttga aggacccaaa agtcaaacaa aaggtggatg aactgatcga 961741 gattgtcaga ttgaaaggat cggaaaaagc atatccgcgc gagctgtcag gcggcatgtc 961801 acaaagagta gccatcgccc gggccctgct gcgggagcct gaggtgctgc ttttagatga 961861 accgtttggt gcactcgacg cttttacaag aaaacacctg caggacgtgc tgctggatat 961921 atggaggaag aaaaaaacaa cgatgattct cgtgactcat gatatagatg aatctgttta 961981 tttaggaaat gagcttgcga tccttaaggc caaaccgggg aaaatccata agctgatgcc 962041 cattcacctg gcgtatccgc gaaaccggac gactccggat ttccaagcga tcagacagag 962101 agtgctgtcg gaattcgaga aaacagaaga tttggagtac gcagaaggat cagggatata 962161 gaaagggcgg aagcggaaat gaaaaaagga ctcattgtat tggttgccgt tatttttctg 962221 ctcgcaggct gtggagcaaa tggagccagc ggtgaccaca aacaattgaa ggaaattcgt 962281 attggtattc agcaaagctt aagccccctt ttgattgcaa aagaaaaagg ctggttcgaa 962341 gatgcatttg aaaaagaagg catcaaagtg aaatgggtgg agtttcaaag cggtccgccc 962401 caatttgaag gccttgcggc agacaaactt gatttttctc aagtcggtaa ttcgcctgtg 962461 atcgctggac aggcggcagg cattgacttt aaagaaatcg gtttgtctca ggacggcttg 962521 aaagcaaacg gcatccttgt caatcaaaac agcggcattc aagacgttaa gggcttaaag 962581 gggaagaaaa ttgcagtcgc caaaggcagc agcgggtttg attttttgta taaagcgctt 962641 gatcaagtgg ggttgtcagc taacgatgtg acaattattc agcttcagcc tgatgaagca 962701 gcttccgcat ttgaaaacgg atctgttgat gcctggtcca tttgggagcc gtacttgtcc 962761 ttagaaacaa tgaaacacgg agcaaaaatc cttgtgaacg gagaaagcac agatttatat 962821 tcaccgggtt ttactttagt aagaacaaag ttttcagaag agcatccaga cgaagtggtc 962881 cgttttctga aggtgtttaa taaagccgtt gtatggcaaa aggaacatct ggatgaagca 962941 gcggacttat attctgacat taaagatctc gataaaaagg tcgtcgaaaa tgtgctgaaa 963001 aatactgagc cacttaatga gatcatcagt gacgacattg tgaaagcaca gcaggaaaca 963061 gcagattttc aatttcgaac aaaggcgata gataagaaga ttgatgtgaa ggatgttgtc 963121 gataacactt ttatcaaaaa agcattagag gagcattcct caggaggtga tcaatgatga 963181 aagcagaggc tgcgggctcg ctgcccaaaa cgaatgcgga agcggtgcga aaaaagcccg 963241 gaaggaagag atacggctgg atgaaggggc ttttactgcc cgctgtcatc attgccatct 963301 ggcaggtcat cggcgggctg ggggttgtgt ccgctacagt gctgcctaca cctgttacga 963361 ttgttctgac ctttaaggag cttattttgt ccggcgaact gttcggccat ctgcaaatca 963421 gcatttatcg ggcggcactt ggttttttgc ttggcgcggg gcttggattg atgatcggga 963481 ttttggccgg attttccaaa cggacggagc tgtatcttga tccgtcgttg caaatgctta 963541 gaaccgtacc tcatctggcc gtcacgccgc tgtttatttt atggttcgga tttgacgaag 963601 tatctaaaat tttgctgatt gcgctcggtg ccttctttcc tgtctatatc aatacgttta 963661 acggcatccg cggggttgac gcgaagctgt ttgaagtcgc ccgggtgctt gaatttaaat 963721 ggcatcagca gatatccaaa gtgatattgc cggcagccct gcccaatata ttgctaggca 963781 ttcgcttatc gctcggcatt gcatggctcg ggctcgttgt ggcagagctg atgggctcaa 963841 gctcgggagt cggctatatg atcatggatg cgagacagtt ttcacaaacg aataaagtct 963901 ttgcagggat tatcattttt gcagtggttg gaaagctgac ggattccttc gtcaggctgc 963961 ttgaacgaaa gctgttaaag tggagaaaca gctacgaagg ataaaagata taaaggggag 964021 atgaatatgg aaattctttg gtttataccg actcatggag acgcgagata tttaggatct 964081 gaaagtgatg gacggactgc ggatcatctt tactttaaac aagtcgcgca ggcggcagac 964141 aggctgggat atacaggagt tcttctgcca acgggaagat cgtgcgagga cccgtggctt 964201 acagcgtcgg cactggcagg agaaacaaag gacttaaagt ttttagtcgc ggtaagacct 964261 ggtttaatgc agccttctct ggcagccaga atgacatcca ccctagaccg catttcagac 964321 ggccggctgc tgatcaacgt tgtggcaggg ggcgatccgt atgagctggc aggcgatggc 964381 ctgtttatca gccatgatga gcgctacgag gcaacagacg aatttttaac cgtttggcgg 964441 agacttttgc agggagaaac ggtttcctat gaaggaaagc atataaaagt ggaaaacagc 964501 aatctgcttt tcccgccgca gcaagagccg catccgccca tctatttcgg tggttcgtca 964561 caggctggaa ttgaagctgc cgcaaagcat acagacgtgt acttgacatg gggtgagccg 964621 cctgaacaag taaaagaaaa gatagaaaga gtcaaaaagc aagcggcaaa agaagggaga 964681 tccgttcgat ttggcattag gctgcatgtc attgcccgtg aaactgaaca agaggcatgg 964741 gaagcggcag agcgcttgat cagccacttg gatgatgaca ccattgccaa agcgcaggca 964801 gctttgagcc gttacgactc ttcaggccag cagcggatgg ccgtccttca tcaaggcgat 964861 cggacgaagc ttgaaatcag cccgaatctg tgggcgggga tcggcctggt cagaggaggg 964921 gcaggaacag ctcttgtcgg tgatccgcag acgattgccg accggatagc ggagtaccag 964981 gcactcggca tagaatcgtt tatattctcc ggctatccgc atttagaaga agcgtattat 965041 tttgcagagc ttgtatttcc gcttttgccg tttgaaaatg atcggacgag aaagcttcag 965101 aacaaaaggg gagaagcggt aggaaacact tattttgtca aagagaaaaa tgcatgagtt 965161 taactaaaat acagcccccc gaacatggta tgatattcaa aaaaaggggg ctttttttct 965221 gaaaacattg agaagcgcgg cagtcatttg cctcatagct atgctgtcag catgcggaca 965281 ttcaaaacag atggaaatca aagcggcgga catatcagat cttgaaaaaa acagaatgga 965341 tgtcgcagct tcacaggcat tcactgccga agccgtcaat atcggtgaag gtatttcttc 965401 agctgacatg tacatcgaac attatcaaaa gggaaagctt gttgagaggt ttggaccggt 965461 tcgtgcagat tattcagagg aaaaaactga taccatacaa tttgtttatt ttgagaatga 965521 agagggggaa ggaaagaata aacataccac cattcatttt ggcattgtgg ataaacaggg 965581 aactatagcg gctgattcat cggtgaaacg cgacgatagc acaacacagg aaatgactca 965641 gaatatttca tcgccggaac cgattacttt cgagaagcct gctttgatcg gcagcagtat 965701 tagagggact gacgagacaa tgcacacctc tgaacataaa aaagagctca ttaagcatca 965761 agatgcgtta ctgtattatg tggaattgca tcattagaat gggcggcttc aggccgtctg 965821 ttttacaaag cggtatgctt gcttttttga atggtgaatg atacatttta aatcgtaaca 965881 atttcgattt aaagggaggc tatgtgactt ggctaaaaaa tcaaaagtgg caaaagagtt 965941 aaaacgccaa cagcttgttg agcaatacgc tggtattaga cgcgagttga aggaaaaagg 966001 agattacgag gcactcagca agctgccaag agattcagca ccgggaaggc ttcacaaccg 966061 ctgcatggta acggggcgcc cgagagcata tatgaggaag tttaaaatgt ccagaatcgc 966121 tttcagggag ctggcccata aaggccagat tcccggtgtg aaaaaagcaa gctggtaaga 966181 aaaaactccg gccgattaca gcgcgccgga gtttttttcg tttttcttga aagagatgac 966241 gtaggaaagg tgctggatga tcatgatgat aaacacaata ataataggga aaaacggaat 966301 gcgcgattga aatagcggat aaaaaatgag aagaaccgct gcggcaggca gcgagaagta 966361 gacagcgata tatgacgcgc gacatgcttt tgccgtcatc atctgctctc tttcatcctg 966421 ctcttcaaac tcatcaggca gaagtagctg ctttctggca gggcggcttt ttttctgtaa 966481 gtacaaataa accgcagacg ccgcaacaaa cagaataaag ggagtgaggt ttaaatcaaa 966541 taccatcccg ccgctctttg tgccgaaaaa agatgctatg ccttctgagg cttcaaagta 966601 tgaaatcagc gcccagcatg caaggccaaa taaaacaagg tgaaaagctg cttttgtttt 966661 catgctcatc ttagttttcc tcctctaacc aaaagacatc ctccattttc atggagaagg 966721 ctttgcagat tttcagtgct aacagcagtg agggaacata atcgcctttt tcaatcgctg 966781 ccacagtctg tcttgtgacg ccgaccgttt ctccgagttt ttcctgagaa tagccgaagc 966841 gtgccctcag ctcttttact ttatttttca tcatgacgtc tgtccccttc acaatctcga 966901 ttgattatat tgtatagtat acttaacatt atgtaaatgg aacttaacaa ctttacaaaa 966961 agataacttt ttttcgacaa aatttttata ttcccttgac gaaaaataaa taaacatgta 967021 atataaaaaa agtcagagcg gtactgttgc tgacaatcac aaatgcgggt gtagtttagt 967081 ggtaaaacct cagccttcca agctgatgtc gtgagttcga ttctcatcac ccgctccata 967141 catacgttat taacgcagtg tttcgtttct cagataaacg aagtattgcg tttttttatg 967201 tgaaaaagaa cacggtattc gtgttctttt acgtaagcca atgtactgta tgggtgccgc 967261 cgtgaatttg ttcaaacatt ttcgttaatg atgataagag gttaacagcg ctgcttttct 967321 caatcgatgg cgggaaaaaa atgatttgca gcatattctt agtctcgttt gaaacgggat 967381 agtggttgac gctgtttttg aaatcgccaa aaatgccgtt ttcatcagag aaaagcagta 967441 tgttttcttt ttctcccaat gagatccgga ccggctcatg aagctttccg gcatcataaa 967501 tcataatagg cagagaatat tttaatgcga aaaaatcgat tgtgtcatgg gccgagtctt 967561 tactttccat gaattgttcc ttggatatcg ggaccagcat gtcctccatt ggggttgttt 967621 ctccctcaaa tgaagggtta agctgtttaa agagtttctg ccattccttg acgaaggatt 967681 catcggatat accgccgtcc gcatagtcga aaaacaagga ttcttgaaac aggcggagtc 967741 tgcctttcag catttgcggt gaggagccga cttcgatatt ctcataaatg acagcagctg 967801 catgtaagcc ggccgcacgt tcagtaataa cagaatcaag tttgatattc actagcattc 967861 actccagtta cgtgatatca acctattata aacgctgtgt cgttttatca caaagaaagg 967921 aggctgtgca aaacatgaac gtttatcagc tcaaagaaga attaattgaa tacgcgaaaa 967981 gcattggcgt agacaagatt ggttttacga ccgctgatac ttttgacagt ttaaaagacc 968041 gtttgattct tcaagaatca ctcggctatc tctccggctt tgaagagcca gatatcgaaa 968101 aaagggtgac gccgaagctt cttttgccga aagcgaaatc aatagtggca attgctctcg 968161 catatccttc cagaatgaag gatgcgccga gaagcacgag aactgagcgc aggggcattt 968221 tttgcagagc ttcctgggga aaagactatc atgatgtgct gagggaaaag cttgatctgc 968281 tggaggattt tctaaaaagc aagcatgagg atatcagaac gaagtcaatg gttgatacag 968341 gtgaattgtc tgatcgcgcc gttgcggaac gtgccggaat cggattcagt gcgaaaaact 968401 gtatgatcac aacacccgag tatggctctt atgtgtattt ggcggaaatg atcacaaata 968461 tcccttttga gcctgatgtg ccgattgaag atatgtgcgg gtcctgcacg aaatgcttgg 968521 acgcctgccc aacgggagca ctggttaatc ccgggcagct taatgcgcag cgctgcatct 968581 cttttctgac ccagacaaaa ggatttttgc ctgatgaatt ccggacaaaa atcggaaacc 968641 gcctgtacgg gtgcgatacg tgccaaacgg tatgccctct caataaaggg aaggattttc 968701 atcttcatcc ggaaatggag cctgatcctg agattgccaa accgttattg aagccgcttt 968761 tggccatcag caatcgggaa tttaaggaga aattcgggca tgtctcaggt tcttggcgcg 968821 gaaaaaaacc gattcagcga aacgccattc tcgcgcttgc ccattttaag gatgcttccg 968881 cactgcctga attgacggaa ctgatgcaca aggatccgcg tcctgtcatc agggggacag 968941 ccgcatgggc aatcggaaaa atcggagacc ccgcctacgc ggaagagctt gaaaaagcgc 969001 tggaaaaaga gaaggatgaa gaggcaaagc tggaaattga aaaaggaatt gagttgctaa 969061 aagcttcagg catgactaaa caaggcctgt cctgacatac gtatagagca gaaggaaaaa 969121 acacttgaga tcatccaagt gttttttctc tataaaaaag tatggcgggt ggggtgagct 969181 tgaagtacat tttagaacaa ttagcggagg agcggctggg ctttctggtt aacgggcatg 969241 ctatgagaca ggagtctcaa gtcggagacc ttaaagtcat ggagcgtaag aaaaagcttc 969301 tggaaaaacg taaagttgac atcataaaag cgaaagcaaa ggccgtgatt aatcatgtgc 969361 gggttgagga tgacggaacg acctgccttt cgtataccat ccattacgaa tacgtgtgta 969421 aggaacaaga tgacagcttg tatatagaag agcacataga ggagcgaatg gctttcctgt 969481 atgatcacat tttgattagt gatcaggaaa ttgcgaaaaa gccggctgga tttcatgaag 969541 ggaccagtat tattgactat tctgaagctg aagaggaaag agaagcgttt ggcagggctt 969601 ttcaatacga tcgtctcggc gctgtccaat atgccgagaa attttggaac aagcgcaatc 969661 ctgcttataa aaatttcagc gataactgta caaattttat ttctcagtgt cttcatgcag 969721 gaggcgcgcc gatgcgcggt catccgaaca ggggatcagg ctggtggatg aaacaaagct 969781 catggagcta cagctggacg gtggctcact ctatgaaaat gtatttgtcg aattcaaagg 969841 ccggactgcg tgcggtgcgg gtgaaatcag cggaagaact gatgccgggc gatgtgattt 969901 gctatgactt cgaaggagac ggccggttta atcatacaac gattgtcgtg gcaaaggaca 969961 aaggcaatat gccgcttgtc aacgcccaga cttatgacag caggatgagg tattggtcat 970021 atgaggattc tacggcatac acgccgtcaa tacgatatgc cttttttcat atcgttgatg 970081 atacgacaaa agagtaatta atgttataat gatgggcgga taagaaaaac agaggtgaac 970141 attgtggcat tacatgtcgt tttatatcaa ccagaaattc ccgctaacac agggaatatt 970201 gcacgtactt gtgcagcaac caatacaacg ctacacctga ttcgtccgct cggcttttca 970261 acggatgata aaatgctgaa gcgtgccgga ctcgattatt gggagtttgt taacgttgtg 970321 tatcatgatt cgttagaaga attgtttgag gcatataaaa aaggcaagtt tttctttatt 970381 acaaaatttg gccagcagcc tcatacatca tttgattaca ctgatcttga cgaggattat 970441 ttcttcgtgt tcggaagaga aacaagcggt ttgccaaagg atttaattca aaataatatg 970501 gaccgctgcc tgcgtcttcc gatgacagag catgtcagat cgttaaatct gtccaatact 970561 gccgcgattc ttgtttatga agcgctgcgc cagcaaaatt accgtgattt aaaatagtga 970621 aaaacccgct catcgatgat gggcgggttt ttttgcggat gttgaaatgc tttgtttcgt 970681 ttttgggctt aacaacgtaa cagtgttatg ttacaatgta cccatcaaag gagctggact 970741 tatggaagaa caattaatct ctaaaaaaga attacttgaa agaacatcga tttcatacgg 970801 tcagctgtat cgatggaagc ggaaaaactt aatacctgag gaatggttta ttcgtaaatc 970861 cacatttaca gggcaagaga cgttttttcc gagagaggag attttaaaac gtatatcaat 970921 gattcaaaag atgaaagaaa atttgtcttt ggatgaaatg agggaaatgc tgtcgccgaa 970981 aatgaaggat gtcagcatga ccgctgatga attgcttcat aaaggtttgg tttcaaggcc 971041 tgctcttgaa gcctattcag aagacggagg aagtccggtt ttttcatcca gcgatttgct 971101 ttcgctgttt gtgcttgagg gcctgctgca gtctggaaat gtcagccttg cagaagcaaa 971161 aatggctgca gaggtattaa agaagcatga tactgaagag attgaaaaac agacggagct 971221 gattgtgctc cgcaagctcg gtgtcacaac ttgttttata gcggctgcgg cggacagcat 971281 tttgtttgaa tcatccgtaa aggttgtgga acgggtagat ttattaaaag cttcagagga 971341 attaaaaaca acatttatgc aggagggcca tcaatggatg tagtggaaaa gctggtgata 971401 aatggatcag gaagttctaa gggaggaaca tttcaatcag ttgagattaa tggcagcggg 971461 acagtggccg gggacgtgga gtgtgacact ttttctttta atggaaacgg aaaagcggac 971521 ggcagcgtca aagcgaaagc ggtaactatc agcggttcag gaaagataca tggagacgtt 971581 gaagcagaat ctatccggat gaatggcact ggttttattc aaggagaggt atctgcaaaa 971641 caattgaaaa tcgctggatc atcaacattt ggcggcactg tcaaggctga tggaattgac 971701 attagcggaa aagctgtcat ggaagcagat tgtgaaacag aaacctttca atcagaaggg 971761 aaatgcaaaa tcagcgggct tttaaatgca gaccaggtga tcattaagct ttctgcaggg 971821 gaaagctatg cgcgggagat cggctgccgc catcttcaag tgacctgcag aaaaggaatg 971881 ctgacattgc tcagattgat gccgcagcct gttctaacag cagagctgat cgaaggtgac 971941 gtgattgaat tgacaaatac aaaggcgaaa accgtgcgcg gtaataaagt gatcatcggc 972001 ccggattgcc agattgaaac cgtcgaatac agcggggact atacctgtga tccaagcgcg 972061 tcggttgaaa catccacaaa gttgtaagga ggatcgtaat ggagacaaca aaactgggaa 972121 atttaaaatt atatggcgct gggcatgccg caggaggcgc gtatcacaat gtcagcatca 972181 aaggagaagg tatagttgga gaagggctgt ctgctgtagg ctgccgcata tacggaacgg 972241 gcctttttct cggaaaagca gagactgagc ggctgcgtgt gctcggagaa agtgaatgta 972301 aaggcgatct gacagccggc aaaatcaata tatatgggac aatgaaagtc agcggctcac 972361 ttcaatttga tcgattcaat ctgaaaggcc agactgaaat tggcgggaat atgactggag 972421 aatcctgcga tgtgaaaggg aagcttagcg taataggtga ttgtgaaaca gaaatgttcc 972481 atgtcacagg ctgtgttgat gtatcggggt tattaaattc gggtgagatc aagctgggat 972541 tgagccatga tataagccat gtgcaggaaa tcggcggaac aacaattaca gtgaaaagac 972601 gcgcgagttt ttttagccgg aagaaaggga agctgatcgc cgatgtcata gaaggagatc 972661 gggtttattt ggagaatacc gaagcggcag ttgtcagggg aaaagaagtg atcatcgggc 972721 cgggatgcag catcggaacg attgagtacg aatacaaatg tgaatgcgat ccgcattcac 972781 agattaaaga aaaaacaaaa ctgtaaaaca ttgttctgtt atacaaaaag ggtgctcttt 972841 caggagcacc cttttttatt cttttccagg cttgctttcg tatcctgcgg taaaaattga 972901 tactaaaaaa gtgacaatga cacccatcat gatgattgtt ttcaccgtct ctccccctct 972961 tcaatttttc cgtgctgtcc gagtctggat gattctgtat ttttctttat tatgaacggt 973021 cgcagtctgc cttgtcaacg atgtatgagt atctttattt ttaagaaacc aaagcatgta 973081 tcacgagatg gcggcataga ttgtatcaaa gtaccttatt tgcatagtgt atcaaacatg 973141 atagaggagg tccttatgga tatattaaag aaaattgaaa agtacagaga ggaagagcag 973201 cggctgaaat gggaaggaac tttcgccgat tatttggaga ttattaaaga aaatccgatg 973261 gtcgcgcaat ctgctcattc tcgagttttt aatatgataa aagacagcgg gatagaggag 973321 attgacggac gcaagaagta cagttttttt gaccgcgagc tgttcgggct tgaagaatct 973381 ctggagcgtc ttgtggaaga gtattttcat ccggctgcca aacgtctaga tgtcagaaag 973441 cggattctat tgctgatggg gcctgtgagc ggcggtaaat ccacgctggt cacaatgctt 973501 aaaaaaggtc tcgaagcgta cacgctgaca gataatggcg ctgtatatgc gattaaaggc 973561 tgcccgatgc acgaggaccc tctacattta atcccccatc atttacgcga tgacttttac 973621 agagaatacg gcattagaat agaaggaagt ctttctcctt taaatgtcat gaggctggag 973681 gaagagtacg gaggaagaat tgaggatgtg aaggtggagc gcatcttctt ttcagaagat 973741 aagcgtacgg gaattggaac attcagtccc tctgatccga aatctcagga tattgccgat 973801 ttgacgggga gtattgattt ctcaacaatc gccgagtacg gttcagaatc agatccgcgc 973861 gcttatcgat ttgacggaga gctgaataaa gcgaaccgcg ggatgatgga gtttcaggag 973921 atgctgaaat gtgatgagaa atttctctgg catttgcttt ccttgacaca ggaagggaat 973981 tttaaagctg ggcggtttgc gttaatttct gctgatgagc tgatcgtggc tcacacgaat 974041 gaaacggagt atcgctcatt tatttctaat aagaagaatg aagccctgca ctcaagaatc 974101 atcgtgatgc cggttcctta taatttaaaa gtgtctgagg aagagagaat ttatgaaaaa 974161 atgattgcag aaagcgatgt ggcggatgtt catattgccc cgcatacgtt gaaggtcgcc 974221 gcgatgttct caatccttac ccggttaaaa gagccgaagc ggtcggatat tgatctggtc 974281 aagaaaatga gactgtatga tggggaaagt gtggaaggat ataactctgt cgacgttgag 974341 gatatgaaaa aagaatataa tgatgaaggc atgagcggaa ttgatccgcg gtacgtgatc 974401 aaccggattt cttcaacgat tatcagaaaa aatatggaat cgattaattc tctcgatgtc 974461 cttcgctcct taaaagaagg tcttgatcag cacccatcaa tttcaagcga ggacagggag 974521 cggtatttga attttatctc tgccgcccgc aaggaatatg acgatattgc gaaaaaggaa 974581 gttcaaaaag cgtttgttta ttcatatgaa gaatcagcaa aaacacttat ggacaattac 974641 ctcgataacg tagaggccta ttgcaataaa aacaagcttc gtgatccttt gacaggagag 974701 gaaatgaacc ctgacgaaaa gctgatgaga tccatcgaag agcagatcgg catttcggaa 974761 aacgccaaaa aagcgttccg cgaagaaatt ttaatccgca tctcggccta tgcgagaaaa 974821 ggcaagcggt ttgattacaa ttcccatgaa agactgcgtg aagctattca gaaaaagctg 974881 tttgctgatc tgaaggatgt cgttaaaatt acgacctcaa caaaaacgcc ggatgagcag 974941 cagctgaaaa aggtaaatga agtcgtggcc cgtttaattg atgagcacgg ctacaactcg 975001 acgagcgcca atgagctgct gaaatatgtc ggcagcctgc tgaaccgata agcaacgtga 975061 cccgtccgaa tagggcgggt tattttgtcc cattttctaa atagtttgtc aattaaacgt 975121 gcatatgtgc atatgatgaa tataaatctt ttcaaaagac ttgtttcata atctggcaca 975181 agccggaata cgtatgtatc acgaccacaa atggttaagg aggggaattc atgtcccaaa 975241 atgacagcgg ccattttttg atttctgagg aaaactggtc cctccatcgc aaaggcttcg 975301 atgaccagca gcgccaccag aaaaaagtgc aggaagcgat caaaaacaat cttccggacc 975361 tcgtaactga ggaaagcatt attatgtcta atggaaaaga tgtagtgaag atcccaatcc 975421 gttcacttga tgagtataaa atccgttata actatgataa aaataaacat gtagggcaag 975481 gagacggcga gagccaggtt ggagatgttg tggcccggga tggatcagac aaaaaacaag 975541 ggcctggaaa agggcagggt gccggtgatc aggcaggcga ggattattat gaagcggaag 975601 tttcattaat ggatttagaa gaagcgcttt ttaaagaatt agagcttccg aatctccagc 975661 aaaaagagcg ggacaatatc attcatacag atatcgagtt taatgatatc cgtaaaacag 975721 ggttaaccgg taatattgat aagaaaagaa cgatgatgtc agcctttaaa cgaaacgcaa 975781 tgtcaggaaa accgtcgttc tacccaattt atccggagga cctgaaatat aagacgtgga 975841 atgacatcac aaagcccgaa tcaaaagccg tcgttttagc catgatggat acaagcggca 975901 gtatgggggt ttgggaaaaa tacatggcca gaagcttctt tttctggatg acccgttttt 975961 tgcggacaaa atacgagact gtggaaattg aatttattgc ccatcataca gaagcaagag 976021 tggtctcgga ggaggatttt ttctcaaagg gagaaagcgg cggaacaatt tgttcttccg 976081 tatatcggaa gtcgcttgag cttattgatg aaaagtacaa tcccgcccgc tataacattt 976141 acccgtttca tttttctgac ggtgacaacc tgacatctga taacgcgcgc tgtgtgaagc 976201 tggtcaatga tattatgaag aaggccaatc tgttttgcta cggcgaggtc aatcagtaca 976261 acaggcattc aacgttaatg tctgcatata aaaatgtaaa agatgagaaa tttaagtact 976321 atattttaaa acagaaatct gatgtttttc aggctctaaa gaactttttc agaaatgaag 976381 agtctggtgt aagccatcaa ttttcgtaat gaaaagccca tttcagggct tttttttatt 976441 taataaaagc aagaaaacgc ttgcgaaaaa aatacgggag aaaaagaaat ttttcctttg 976501 acaaatcttc tttcatttat taatatttta tcttgtgaac tattattgag gaatgaggtg 976561 aaaaggagtt gactgaatca gaacgtgctt tgctcacttt tgaacagctc ttcgatacgt 976621 ctcgggcgat atataaaaaa cagaagaaga tattggagat tgtgcttgag ccttttgata 976681 ttacagtcct tcaatatttg ctgatgttta aaattcatca aagcggaagc accccgctaa 976741 gcaagctggc aatgtcgctt gatcttaagc ctgcttctgt gacgcggatg acagatattc 976801 tgtataagcg ccaattgatg aatcgatatg acagtccgga tgaccgccgt atcgtcatga 976861 ttcagttaac cgaagagggg gaagaactga tagaaaaagc cgctgtgcaa tatgcaaaaa 976921 tgggtgctgg cttgtaccaa aagcttgata cctcccagct gcagtatttg cgcaaactag 976981 ccggaagttt aacgaagctt gctgaaggct gttcagaaaa aagcggtaat taaaaacttc 977041 tcacatattt tcaccagctt tccgcaaaat gatagaggat gaaacgaaag gagaaaacaa 977101 aatgaacaga ggacgtttaa ttctgaccaa cattatcggt ttgattgttg ttcttgcaat 977161 tatagctgga ggtgcttact actattatca aagcacaaac tacgtaaaaa cagatgaagc 977221 aaaagtagcg ggcgatatgg ctgctattac tgctccagca gcaggtaaag tatctgactg 977281 ggatctggac gaaggaaaaa cagtgaaaaa aggcgacaca gttgcaaaaa tcaaaggtga 977341 acaaactgtt gacgtaaaat ccattatgga tggcacaatt gtgaaaaacg aagtgaaaaa 977401 cggacaaacc gtacaagctg gtacaacaat tgcacaaacg attgacatgg acaacctata 977461 catcacagca aatattaaag aaacagatat tgcggatatt gaagtaggaa atagtgtaga 977521 cgtagtagtt gacggagacc ctgatactac atttgacggt actgtagaag aaattggtta 977581 tgcgactaac tcaacttttg atatgcttcc ttctacaaat tcaagcggaa actacacaaa 977641 agtaacacaa aaagttcctg tgaaaatttc aatcaaaaac ccatctgata aggtgcttcc 977701 tggaatgaat gcatctgtta aaatttctga gtaaaacaga tcagtcatca aaccatgaaa 977761 ggaggttgtc ttagatggct acaggcaaag aaaaaaatgc aaaaaaccct atgtcattgc 977821 tgattgtgct aatggcgggt ttatttttgg caattctaaa ccaaacactg cttaatgttg 977881 caatgccgca cttaatgact gaatttggcg taagtgcaac gacgattcag tggctgacaa 977941 caggttacat gcttgttaac ggtgtattga ttccgttatc tgctttcctg attacacgat 978001 ttggccagcg gagtctcttt ctcgtcgcga tgttttgttt tacgctcggt acgttagtct 978061 gcggtatcgc acctaacttc tctacaatgc tgatcggccg tttgattcag gccgtgggcg 978121 gaggtatctt gcagccgctc gttatgacaa ccattctgtt aattttcccg cctgaaagca 978181 gggggaaagg aatggggatt ttcgggctag cgatgatgtt tgctccagcg gtcggcccga 978241 ctctttccgg gtggattatt gagcattata catggcgcat tatgttttac ggacttgtgc 978301 cgatcggcgc aattgttatc attgtggctt tcttcatctt taaaaatatg gtggagccgc 978361 aaaaaatcaa actcgatact cttggcgcaa tcctctcgat tgtcggattc gcctccttat 978421 tatacggagt cagtgaagcc ggatctgacg gctggaccga cccgattgta ttgtctacag 978481 ttattatcgg agccattgca attgttgctt ttgttgttca gcaattgcgt catgatgatc 978541 cgatgcttga tttcagagtg tttaaatatg acattttctc actctcgagt gtcattaata 978601 tcattattac agtggcactt tacactggta tgttcctttt accgatttat ctgcaaaacc 978661 tggtcggctt tacggcgctt caatccggtc tgcttctgct tccgggtgcg atcgttatgc 978721 tgattatgtc accgatctca ggtattttgt tcgataaatt cggaccgaga ccgcttgcga 978781 ttatcgggct tctcgtgaca gtggtaacaa cgtatcaata cacgcaattg acaattgata 978841 caccatatac acacatcatg ctgatctatt caattcgtgc atttggtatg tctctcttaa 978901 tgatgccagt catgacagcc gggatgaacc agcttcctgc ccgtctgaac agccacggaa 978961 cggcgatgag taacacgctt cgccaaatca gcggatcaat cggaacaagt ttaattacga 979021 cgatttatac aaaccggacg acattccatt attcacaaat tgcagataaa acaagcacgg 979081 cggacccgaa cttcctccat gcgttccaaa atgcagtttc gaatttaatg gtgaatatga 979141 atgtgtctta tgatacggcg aaaacatatg tgtactcaca tatttataaa cacgcatcac 979201 tcgattccaa tgtcatgggg ataaatgatg cctttatgtg ggcaacctta ttctgtgtag 979261 caggtttgat tttaagtatc ttcctgcgtg acgtcagaaa agataaattg cgtaagaaga 979321 aaaaagagga gctttcatta cttcctgctc caaaagaagc taaggaatct taatctgtac 979381 agggaggttt cctgaatgaa aatttatgta gtgtatgata gtgaaggcga acatactaaa 979441 gtgcttgcag aagcgattgc tgaaggcgcg agagaaaacg acgcggctga agtgttcatc 979501 gaccatgtag atcaggctga tatccgcaag cttaaagata tggatgcgat tatttgggga 979561 tgcccagggc atttcggaac aatcagctcc ggtcttaaaa cttggatcga cagacttggc 979621 tacttgtggg ctgaaggcga gctgatcaac aaagtcggtg ctgtcttctg cacaacggca 979681 acaacacacg gcggcttgga aatgacaatg cacaatttaa tcacgccgat gttccaccaa 979741 ggcatgattg ttgtcggact gcctggcaac gtgcctgaaa acgcacttta tggctcttat 979801 tacggagcag gtgtcacttg tccggtagac agtgatgagt taatgtctga ggaaggtatt 979861 cagcttggac gcgcgttggg aagacgtgtc agccaagtca caggaaacct aacagcagga 979921 cagtaaggag aggttgaaat ggccattatt atagcaataa ttgctgctgt cattgtcatt 979981 gcggccctta ttacatttaa cgtccgcaac gcctcacctg gacctgagaa gcaagaagca 980041 accgatagaa tcgcacctcc agaagaggaa aaaaacgaag cgcattaccc tgctgaagca 980101 agggctgccg agcatacgcc atccgttgtc aaaaacgatt ctccaaaaga gaagcgtgac 980161 acaatgggtg atgatattta caggcaggcg ctgcaaaagt ttaagcattc tgatgaagtt 980221 catgcagaag aagaggtcac tgaggaaagt gacaaaatgc aggaccgcag ctatcgtgat 980281 gcgctgctct ctatgaaaaa taagaaaaag taatgaaaaa ggcaaatccg tttactcatg 980341 cgggtttgcc ttttttgctg tttccatcaa ttatgttttt atcaaataaa tccatggaat 980401 atgttgtatt ccaccttgat ctagtgtact atgttactca tacaccgagg attttttccg 980461 ggaggtaaag acatgaattc ttttttaggt ttattaaaga aagatatcaa gctttcaaga 980521 atgtggctgc tagtatggat atgcggaatc attttcttat tgggaacagg ccatattata 980581 gcttctcgca cgaaagaacc tctagtcatt tttggttttt ttgttgcagt tgcttttttt 980641 ctgcttttct tatctcctgt ttttgttttt tatcaccttc gcaaggaagg gaaatcacag 980701 ctttggctgt acaatccaaa tggcggctta tggctgtttt cttctaaatt ggcagcatct 980761 ttgctctatc aatttgtgat tcagttggca ttaacagcct atggcatatg gatgtatcat 980821 atgctctctg taaaaaatct gctggagcat caagttgata taacgagtac agtggctttg 980881 ctgaatatgt atgggcttat ttcttcgtta gatatgtcag taacagtcat tgtgttttgg 980941 actgtttttc actctctcag aaattggcgc ggaatgcggt gggctgcgat ggttctgttg 981001 gtcgcaatgt ggttattctt cgatgaatac atcataagcc ctttggttga atctcaaaag 981061 catttctggc ctgtaacagt ctattgcaat tttgatttcc acttccacaa tgtttggaga 981121 ttggaactaa aacctatcca tctgtctgtg ctagggtttc ctattgctat agtcatcaca 981181 ttcttgctgc tcatcatggc ttcaaaactg cttgatcgta aagtagaggt gtaaatatgg 981241 acaatcaatt ccaatcctcg aaaccgattt atctgcagat cgctgatcag atcttttata 981301 ggctggtcag gaaggagctg ctcccaggag acaagcttcc ttcagtaaga gaaatggcga 981361 ttcaaactaa agtaaatccc aatacaattc aaagaactta cagtgagatg gaaaggctgg 981421 gtattgtgga gacaagaaga ggtcaaggga cgtttattgc ggaaaaagca gaaatcgtag 981481 acgagctgaa agacaagctg acacgagagg tgctggaagg ctttgtcaag caaatgaaag 981541 agctggggct aacgaaagaa gaaatgttag aagggattaa aacattcaca gagggaggct 981601 aaaatggaaa tcaagctaga acatgtatca aaaaaatacg gccgccatac ggccgtcaat 981661 gatgtgtcaa tcaccctatc atccggacgg atttatggcc tgattggacc gaacggcagc 981721 ggcaagtcaa cgaccctgaa aatgatggct ggccttctgt ttccgacttc aggatttgta 981781 aaagttgatg aagagcaggt tacgagagaa atggtgcgtc aaacggctta tcttactgag 981841 cttgatatgt tttatccgca tttcactgtt aaagatatgg tgaattttta tcagtcgcag 981901 tttcctgatt ttcatacaga acaggtttat aagctattga atgagatgca gctgaatccg 981961 gaaaaaaaga tcaaaaagct atcaaaagga aatcggggca ggctgaaaat cgttcttgct 982021 ttagcgagac gggcagacgt catcttgctt gatgaacctt tttccgggct tgatccgatg 982081 gtcagggatt ccatcgtaaa cagccttgtg tcgtacattg attttgagca gcagattgtc 982141 gtgatcgcga cacatgaaat tgatgaaatt gagactttgt tagatgaagt aatcatcctc 982201 gccaatggag aaaaagttgc gcagcgtgaa gtagaagata ttcgtgaaca ggaaggcatg 982261 tctgttttgc aatggtttaa atcaaaaatg gaagtttgct agaaagagga ggaatatgat 982321 gaaaacagtg ttggaattga aaaacgtgac taaaaacatc agaggccgaa cgatcattga 982381 tgatctcagt tttacgattc gtgaaggcga ggtattcggt tttttaggac caaacggagc 982441 ggggaaaacg acaaccatcc ggatgatggt ggggttaatg aagctgtcga aaggtgatgt 982501 cctcatttgc ggccaatcaa ttacgaaaga atatgccaag gcgattaagc atatcggagc 982561 gatcgttgag aatcccgagc tgtataaatt tttgagcgga tataaaaatc tccagcaatt 982621 cgcaaggatg gtcaagggtg tcacgaagga aaaaattgat gaagttgttg aactggtcgg 982681 tttaacagac agaatccacg acaaggtgaa aacatattct ctggggatga gacagcgtct 982741 tggcttggca caatgccttc tgcacgatcc gaaagtgctg attttggatg aaccgacaaa 982801 cggccttgat ccggcgggga tcagagaaat cagagatcat ttaaagaagc tgacccgaga 982861 aagaggaatg gctgtcatcg tttcaagcca cctgctgtca gaaatggaac tgatgtgtga 982921 tcgaattgcg attctgcaaa aaggaaagct gatcgatatt caaaatgtaa aagatgaaaa 982981 cattgatgag aatgatacat atttcttcca ggttgagcag ccgagtgaag ccgctactgt 983041 tttaaatcag tacgatttgc tgagtaagac aaatggtgta gaaatcaaac tggctaaaga 983101 ggaagtccct gcggttattg aattgctggt gatgcagcaa atccgtattt atgaggtcaa 983161 ggtcataaca aaatcattag aggaccgttt cttagaaatg acaggtgaaa caaaagagga 983221 ggttcagcat gcttaatttg atttataatg agtggctcaa aattttcagc cgtgccggaa 983281 catgggtgat gatcggaatt ctggggctga caatggttgg atttgcattt ttggcgaatc 983341 atttttctgc cggtgaatca aattcccatt ggaaacaaga gcttcaagca caaaacgccg 983401 aattaaagaa agaaatcaaa gaagatcctt cactgaaaga tgggtataaa gaaacaatca 983461 cactcaatga ctatcgcatc gagcataata tccctagtga cacgggctat acggtatggt 983521 cttatgtaac ggattcagca aactttacca tccttaccgg tctgtttact attatcatcg 983581 cggccggaat tgtcgcgaac gaatttaatt ggggaacgat taagctatta atgattcggc 983641 cgctcagtcg ttttcaaatt ttgatgtcca aatatattac agttctcctg tttgggctcc 983701 tgttgctgtt gattttattt atcggttcta ctttattagg gttgatcttc ttcggaacgg 983761 gtggtgaaac cgccgcgaat attcatttaa tctataagga tggccatgtc attgagcaaa 983821 acatgatggg gcatttggct acaacgtatc tttctgaatc cgtctcggct ttaatggtgg 983881 cgacgatggc gtttatgctg tctgcggtat tcagaaacag ctctcttgcg gttggttttt 983941 ccatcttctt gttggttgcc ggtacgactg caactgcatt tattgcagcg aaatttgact 984001 gggcaaagta tatattgttt gctaatgtcg acttgactca gtatgtggat ggcacaccgt 984061 taataaaagg gatgactatg acgttttctc tcgtcatgct ggcgatctac tttatcatct 984121 tcctgttgct tgctttcgga atcttcatga agcgggatat tgcaaactaa taaaaaaagc 984181 tgttttgctt atgcaaaaca gcttttttgt caaaataaaa actgcaggtt tgcacctgca 984241 gtttttcata tcaatttatg cttacgcttc tttagtaacg ttagcagctt gtggtccgcg 984301 gtttccttca acgatttcaa aagaaacagc ttggccttct tctaaagttt tgaagccttc 984361 gccttgaata gcagagaaat gaacgaatac atcgtcttga ccttctactt cgatgaatcc 984421 gaaacctttt tcagagttga accattttac tttaccttct aacatgaaat ttcctcctaa 984481 agcgatcata acgcttaaat tcactattct tgctcttaac aaactttcaa gacgaaaact 984541 cttacaaaac tttcttctta aagatagttc gaacaaaaat aattaccttt actctaccag 984601 taatcttcag aaaaaacaac tgcttattga aatttttttc ggaaaatacc atatttattt 984661 ttcaatttga tatttattta cggaaattca tctgttttct cgatatgtga tcatacgttt 984721 gccttagtat tccttcattt tgggaagata agtaatagga attgacaacc ttattggata 984781 tgagtaaggt aaaagttaat caatattaca aatgacaacg tttatcaact aagagagcgt 984841 atgattttta tgtctgatat tgcttgcatg ctctaataca tagataggag tatggtcaca 984901 atgaaaaagt ggcttatatg cagtttcgtc cttgttcttc tcgtttcatt tactgcatgt 984961 tcaccgtctg cagaacatga atcgataaaa atcgggattg ctgagtctga cggggcaata 985021 tggaactata ttgctcaaaa ggctgaagag gcagggctgg atattcagct gatccctttt 985081 tctgattatg cggagtctga tatcgcactt gctaacaaag aaattgatgc caacgccttt 985141 caaaccattt catattttca gtcgttcact gaaaaataca aacttaattt ggcaccgctc 985201 gggacgacat acataacgcc catgggcatt tattcaaaac gatatgaacg aatccgagat 985261 atatcgcggg gagctgtcgt ttctgttccg gataaagcgt tcgattttgg cagggcgctt 985321 acggtgctcc aggaagcggg tttgctaacg ctgaaaaacg gatttaacgg aacaggttca 985381 gttgatatga ttaaagataa tccgagacac ctgaaattaa aagctgtccg gcaacaggat 985441 gcagtgagcg gtgccgacgt gtttgtcatg aaaccatcag aagcaaaaaa agcgggcttg 985501 aacccgaaaa agcatacgct aaagagcggc ggactcatgt ctgaggaaga gatgaatttg 985561 attgttgtca gagcggagga tcaagatcgg gaagcgctgc aaaccattct tgagctttat 985621 caagctgatg atacagcggc atttatagaa aaagaatatc agggagatct tgtcccggct 985681 tttctgcctt tgaaacgtct ttcagattgg aagaatgaat tcgaacattg aattcattct 985741 tttttttctg aaaaacacac tctgttccgt cccgtttctt tcgctttgta aagcatttga 985801 tcggcaagaa tgggcaagga tcctggctgt tccgtattat tggggtaatg agcggcccct 985861 agtgatatcg taactgaaag ctcgtcgccg tttgttaata caatcggtgc atcacttaca 985921 gtgctcctga tccgttcagc gatccgggct gctttatcaa gagaacagtt cggcaggagc 985981 acggcaaatt cttcaccgcc gatccgagcg gcaggatcag tatttcggat ggtctgcttc 986041 agacgtaacc ctagctcttt gagcacctga tctccttcat gatggccata ttggtcattg 986101 atggtcttaa aatgatcgat atccatataa atcagtgcaa attgaaaatg cggggtatcg 986161 gccgcctgct gatacagagc ttttgtggtt tcttcaaatt ttcttcggtt atacacgcct 986221 gttaaaaagt caaagtgcgc ctgaaactta tattgtttaa aaagaagatg tgcatttgtt 986281 tcatgatcaa taatatataa actgagcatg ccgcccgcta ttgatatgat ccaaaaatac 986341 aaatgaagtt cgtatgaatg taaatctata agaaaataaa aggaaaagga gatcaagcta 986401 tttgtgatta ttaaaagata gaaagcatgt tttagttgaa ctttttttct tctagaaaca 986461 atgagtgacg gaatggcagc gatacaaatg ataataaccg agtatagtgc agatgtgttc 986521 atcgtaatca gcaagcggcc tgcagtgatc atggccaggg ccgttgccgt tgaaacccag 986581 cctccataaa gagcggcaat cataataggg atatttcgaa gatcaataat tgaatgctga 986641 taggtaaatc caaaaaccat cagaataacc ccgagcaaac cgcaggccag tcctttaaca 986701 gcttgaaagg atatgctgtc ttttttatgt actagccttt ctttaaacag gtgggtgaag 986761 agataattaa atgtgattaa aatggtcaaa tttacaaaca gttctttcag caaatattat 986821 cacccttata taaggtacta aagatggaag ggaaagaaaa gaacaaaaaa ggcattatat 986881 aaggtttttt tacttgaatt gataagttaa aataattcgc acttgaccca tcggaattag 986941 tgtaatatag taaatgagaa aatttgaagg gagagtttac ctgctttgga gactttactg 987001 gttgtattac atgtatttat tttattttta cttatcttag ggctctttgt tatgcagaaa 987061 aaacatgttt ccttctctaa acgtgtattt actgcgctgg ggctggggat tgtattcgga 987121 tttgcgcttc agctgattta cggcccgact tcaaatatag tcattcaaac agccgactgg 987181 tttaatattg ccgggggcgg atatgtcaaa ttgcttcaga tggttgtcat gccgctcgtc 987241 tttatttcga ttctcggcgc ctttacaaag ctgaagctga caaaaaatct tgggaaaatc 987301 agcggtttga ttatcgggat tttagtagca acaacagcag ttgctgcagc tgtcggtatc 987361 gcgtccgcgc tttcatttga tctgcaggcg attcaggttg accaaggaag tacagagctt 987421 tcacggggac aggagcttca gcagaaatca gaggatatga cagcgaaaac gctgccgcag 987481 cagattgttg aactgctgcc tggaaacccg tttttagatt ttacgggagc tagaccgact 987541 tcaacgatcg ctgtcgttat ttttgccgct ttccttggag tggcattcct cggcgtaaaa 987601 cacaaacagc cggaacaggc agaaacattt aaaaaactgg ttgatgccgt ttatgccatt 987661 gtcatgcgtg ttgtcacact cattttgaga ctgacgcctt atggggtgct ggccatcatg 987721 acaaaaacaa ttgcaacgag tgatcttgac agcattctaa aactgggcat gttcgtgatt 987781 gcatcatatg ccgcgttaat cactatgttt atcattcatt tgctgctgct gacgttcagc 987841 ggcttgaatc cggtgattta tttgaaaaaa gcggtgcctg tacttgtatt tgcatttacg 987901 tcaaggtcta gcgcaggtgc tttaccgctg aatattaaaa cacagagaag catgggtgta 987961 ccggagggaa tcgcaaactt tgccggttcg ttcggtcttt cgatcggcca aaatggatgt 988021 gccggcattt atcctgcgat gctggcgatg atgattgctc cgactgtcgg ccaaaatcca 988081 tttgacccgg tgtttattat cactgttatc gcagtcgttg ccatcagctc cttcggggtt 988141 gccggagtcg gcggcggagc gacattcgcg gcgcttcttg ttttatcatc attaaacatg 988201 cctgtcgcgc tcgccggttt gttaatctca attgaaccgt taatcgacat ggggcgtact 988261 gctttgaatg tcagcggaag catgacatcc ggtcttatta caagtaaggt cacaaaagaa 988321 attgatcaag gggcatttca tgatcaatcc agagtgattg aagctgaaga agcgtaacat 988381 atgaaaacgt gtaatccaag aggattacac gtttttttaa cggccaggct ctaagtcctc 988441 cagcatttcc atcatcgtgt tgtcgtccat gacattcatt gcgttttgtt caaaatgaat 988501 gggttcagca taatgcggct gtcttttttt cgcggctgtc tcagtttgcc tagtttgaga 988561 ctgtgtatgc tgatgctgtg gttgctgctg tccagcgtgc tggtgctgac ggccattttg 988621 ccgctggctt tgatgctgcg aacggtcctg gttatcaccg ctgcttccgc tgcttccgct 988681 aaatgcttgt ttgaccatgt ttcctacatt agaagcatca aacgtgttat tttctgaatt 988741 tcgtctgttc atttgtcctg tgataaaccc gctgattctt tggcggatct gaggtgataa 988801 tgcagtaata agcatagttg atcctatgat caatgctgcg gggctgattc ctcttcgctg 988861 gttgaacaac atgatccctc ctttgcagtg tattcatatt ttccccctcg ttagacaaat 988921 taaccgttat atttcccggg aaagcatttc ctccagattt gcatgcataa ttaaagccag 988981 ttagaaaaac ctataagtaa agtgataaag gaggaattca catgtttgga aaaaaacaag 989041 tccttgcgtc tgtgcttctt atccctttgc ttatgactgg ctgcggtgta gccgaccaag 989101 gtgagggcag acgtgataat aatgatgtaa gaaacgtaaa ttatcgaaat ccggccaatg 989161 acgatatgcg gaatgtaaac aatcgggata acgttgacaa caatgttaat gataatgtca 989221 ataacaatcg tgtaaatgac gataataaca acgaccgaaa acttgaggtt gctgatgaag 989281 cagctgataa agtaacagac ctaaaagaag taaagcatgc cgatatcatt gtggctggaa 989341 atcaagccta cgttgcagtc gttttaacca atggaaataa aggtgcagta gaaaacaatc 989401 tgaagaaaaa aatagccaaa aaggtaagat ctactgacaa aaacattgat aatgtttacg 989461 tttcagctaa ccctgatttt gtagagcgta tgcaaggata tggaaagcgt attcaaaatg 989521 gtgacccaat cgccggatta tttgatgaat ttacacaaac tgtacagcgt gtattcccta 989581 acgctgaata aatgaaagaa gccgcacaat ttgtgcggct ttttctttgc gttaatgaca 989641 cactgcgaac tcaggctgca tagagtaaaa ataaaaaggt acaagacgga ccggctcagg 989701 gagggagacg tttgcgggat ggcataggaa agcgtgcggc atccgctcta ttcctgtgcg 989761 gagtccttgt gatgctggct gtaagctcag ccatcgtatc aagcgcgatg tatatcctgt 989821 cttttccagg tcaggcatct ggaataacaa aagaacaagt gacgaagcac atgaagaaag 989881 agtcattcaa acaggccgat atttattaca cttctaagga aaagtcctta ctgccattga 989941 cgaaagaaac gcttgaatat gcggtcagta ttaatcagat tatgattgga tattcgaatc 990001 aaaagcctat tgacattatt ttttttccta atgaaaaaca gatggaggct tactccggtt 990061 tattggatgt agttggtttt tattctgaac gggagcagct gatcggattg ttgcctgaag 990121 agaaaaagaa actgttagaa ggggacgagg tagcggttta tttgtaccag agattgttga 990181 ttcatgaata ctcgcaccat gcgtttcacc agaaattgaa ggagcttgag acggatcccg 990241 atgagtttcc gttatggttt catgaagggt taagcgagtg gattgcgaac tatgaattgc 990301 tcatagatcc gatcacgttt tctgtcgtgc cctttgaccg tttgcagact gatcgagact 990361 ggcaggaagc tagagccgaa tatgacactg atgtctattt gcaaagcttt tatatgatcg 990421 atgagctgac ggacaaatac gggaaagaca ttatttcaga aatgattaag gaaacggcaa 990481 aaaaagggga ctttgaaaaa gggtttaaat cagcaacaaa ggaaagtctt gatcaatttg 990541 aaaaagattt taagaaaaaa tttgaaaaaa acagtgcggc attggatagt atctatccaa 990601 tgcctttgtt attagtgaag tccttgctga cccattccgc cttgtgtcgg aggcatttgt 990661 ccttgggcag gggcgaatga atttcgcagc tgttccatat cctgcgcatc aagctgagga 990721 acctggtaat agccgtgttt gttttggtat aggaaaattt caaatgccat ttcaacatac 990781 tcctgaattt gcgcagacag tacgcgtctt acggccggat ttgtcatttc cagagaagcc 990841 atcgtcagca tagaagcttg tgctttaatc gcgcaaagca tttgtcggct gatgatgctg 990901 tcatcaatat cattcatgga ttgaacaggt tttttaggct gtgacggctg catgccgtaa 990961 acagtctggt tgtcttcctt catcatataa gttgctgttt tttgtgaagg ttcgcttcct 991021 gttttgaagc attctgcagt tatattgtat tgagatgtga tgaattgatg ttgacgatca 991081 aggatgttta gtaattcttg atccttacag aattgtctca gcatcataaa ctgatcaagc 991141 acagtaagtg ttccggaaag cacctcatgc atatcaaaca tttcatgtcc gccgtggttt 991201 ttatgcggtt tgccaggaat acctttgttc atttgggatt gctgctgctg attgaactga 991261 tccaaaccga attcctcctt ttttttcaga tcagctgtat tttgtgtcag tctgccgtgt 991321 attatgcaga agcctgaaag gaattatatg ctgtctgtcg aaatgataag cagacaaaat 991381 cgttgtcatt atgtgtataa gggaggaaat atgatgaggc gtattctgca tattgtgttg 991441 atcacggcat taatgttctt aaatgtaatg tacacgttcg aagctgtaaa ggcagctgaa 991501 ccgcaacagc ctatatcgat tgagaaggca atacagcaaa aagaaggaca ggcacttgtc 991561 gaaggatatg cagtcggcca ggctgtttcc ccgcagcatt ataaactgac aagccctttt 991621 tcaaatgatt ataatgttgc gctggcagac cgtaaaaaca aaacatcgcc cgaacacatc 991681 cttcctgtgc aaatcccctc cgccttcaga agccaatttg ggctgcaaac caatccgctt 991741 cttcttggga aaaagataac ggttcaagga aagcttgaaa attactttaa cacgacagga 991801 cttaaaaacg ttcagtcgat gaacgtaacc gatgacacaa aaactccgcc ggctgaacag 991861 caagtgacca taaatgaagc acggggaagg ctgaatgaag aagtaacgat aaaagggatc 991921 attacagctg atcaaaacgc aatcggaggc gggaagctgt cgaccttttt gcaagatgaa 991981 accggaggca ttaacattta ttcgccatcc cctgaacaat ttcccgaatt aaaagagggt 992041 atggatgtca cggtgacagg gaaaatcacg tcttaccagg ggctgaaaga aatcgttcca 992101 aactcatcag gcatcaaaat caaccagtca aatcaatccc tccccgcccc caaacactta 992161 acaatcaatg aacttattaa cggcagccta ggtgatcagt atgaaggacg ccttgtgaaa 992221 ctaaccgctt ttgtttcctc aattccaagt tctcctgccg gcggcggtta caatgtaaca 992281 atgattgatg acgaccatca tgcaatgacg ctccgggtta tgaatgaaac aggggtgata 992341 aacgagcttg atgagggcaa atggtatgaa tttaccggtg tgttaagcag ataccaaacc 992401 tttcagctgc ttccgcgaaa atcggctgac ctgaagctgc ttgaagagca gcccgcacct 992461 ccgtctgcag agggagaata tgaagggatt gttgaccggg tagttgacgg cgataccatt 992521 catcttaaat ctccggtgct tggaacgaca aaaatccggt ttgtaaatgt agatgcaccc 992581 gaaacatatc acacaccaaa aaatgacgca gatgaaaatc aattaagatt tggcaaaaaa 992641 gcatctgact atctaaaaac ggttctgtcc ccgggtgata aaattactgt caaggtcggg 992701 agtgaagcca aggacagcta tggcagattg ctcggacaag tcataaccga atcaggttca 992761 aacgtgaact tagagcttgt aaaaaacggc tatgctccga cgtattttat ttggccggtt 992821 gacaatgaag aggattatca gcaatttcag gccgcagtag ccgctgcaaa aaaagatcaa 992881 aaaggaattt ggaatgaaaa cgatcccctc atggaaatgc cgtttgaatt cagagccaga 992941 gagcaaggga aaggcctgac aagatatgtg ggggactcgt cgaataaaac atatgtgcag 993001 ccagctgact ggaagaagat agctgtggaa aacagaattt tcttcgcctc agcaagtgaa 993061 gcggagagcg cgggatataa aaaaaggcaa acggcacctc aagaacatgt gccgcttaga 993121 attctcagca tgaatgattt gcatggcaaa atcgatcagc aatatgagct tgatcttgat 993181 ggaaatggaa ctgtagacgg cacgtttgga cgcatggatt atgccgccgc atatttaaaa 993241 gaaaaaaagg ctgaaaagaa aaactcgctg attgtgcacg cgggagatat gatcggcgga 993301 agctctccag tttcctctct tcttcaggat gaaccgactg tagaactgat ggaggacatc 993361 ggatttgatg tcggaaccgt gggaaaccac gaatttgatg aaggcacgga tgaacttctg 993421 aggatcttaa atggcggtga tcatccgaaa ggcacaagcg gatatgatgg acagaacttt 993481 ccccttgtat gtgccaattg taaaatgaaa tcaactggag agcccttttt gccggcttac 993541 gacatcatta atgtggaggg cgtacccgtt gcttttatcg gagttgtcac acagtcggca 993601 gctggcatgg ttatgcctga aggaataaaa aatatcgagt ttacagatga agcaacagcg 993661 gtgaataagg cggccgaaga gctcaagaaa aaaggcgtga aggccatcgc ggttctcgca 993721 catatgtcag ctgaacaaaa cggcaacgcc attaccggtg agtctgctga tcttgcaaac 993781 aaaacagatt ctgaaattga cgtgattttt gccgcgcata atcatcaggt tgttaacggt 993841 gaagtgaatg gaaaactgat tgttcaagcg tttgaatatg gaaaagcgat aggtgtcgtt 993901 gatgtagaga tcgataaaac gacaaaagac attgtcaaaa agtccgcgga aatcgtatat 993961 gttgatcaaa gtaaaatcga accggatgtc agcgcgtcag ccattttaaa gaaatacgaa 994021 acaattgcgg aaccgattat cagcgaggta gtcggcgaag ccgctgttga tatggaaggg 994081 gggtattcaa atgacggcga tacacctctt ggaaacctga ttgcggatgg tatgagagct 994141 gccatgaaaa cggattttgc ccttatgaat ggcggcggca tacgtgaagc gctgaagaag 994201 ggtccaatta cgtggggaga tctttacaat attcagccgt ttggaaatgt gttaacgaag 994261 cttgagatta aaggaaaaga tttaagagag attatcaatg cgcaaatctc gccggttttt 994321 gggcctgact acagcatcag cgggtttacg tatacgtggg ataaagaaac cggaaaagca 994381 gttgatatga aaatggcaga tggcaccgag atccagcccg atgccacata tacattgacc 994441 gtcaacaact ttatggcgac ggcgacagga gccaaatatc agccaatcgg actgctggga 994501 aaaaatccgg tgacagggcc tgaggatttg gaagcgacag ttgagtacgt gaagagtttt 994561 gatgagccaa ttgcgtatac aaaagaggga agaattaagc ttgctgaagc cagtgatatt 994621 gaagaccctg taacagaaga cccgataacg gaagagcctg gagatgatcc ggggacggag 994681 gatccgatta aagaggatcc aaggccaggt gaagatttgc ctgatataaa agaaactccg 994741 ggaacagcac cggttcatca gcttccgcct tcagccattt cgagattcaa tgaaatacca 994801 atcaacaaca caaaaaccgc tgatactgct aatagcatca gcacattgcc gttacaaacc 994861 gagactgcgg aaagcgggtc tgatcatcag cttccggata cgtcagcggg ctactataac 994921 tttatggtaa tcggtgcggc ggtgacattg tcaggaactt atctatatgt cagaagaaaa 994981 aggagcgcct ccagaacgtg aaaaaagtta ttccactatt catcattgct gccggcctag 995041 tgatcgcagg ctatggaggc tttaaattga tcgatacgaa tacgaaaacg gaacagacat 995101 taaaagaagc aaagctggcg gctaaaaagc cgcaggaagc ttcggggacg aaaaatagca 995161 cagatcaagc aaagaacaaa gcatcattta agcctgagac cggccaagcg agcggcattt 995221 tagaaatacc gaaaatcaat gcagagcttc cgatcgtgga gggcaccgat gctgatgatt 995281 tagaaaaagg tgtcgggcat tacaaggaca gctattatcc tgatgaaaac ggacaaattg 995341 tgctgtcagg gcatcgggat accgtgtttc gccggacggg agagctggaa aagggggatc 995401 agctccgtct tctcctgtca tatggagaat tcacatatga aattgtaaaa acaaaaattg 995461 tcgataagga tgacacatct attatcacgc tccagcatga aaaggaagag ctgattctga 995521 cgacctgcta tccgttttca tacgtcggaa atgccccgaa gcgctatatt atatatggaa 995581 aacgagtgac ttaaaaagcc gaggcagtgc ctgcggcttt tcttcatgaa aaatatgtgc 995641 ggcaaaggtt tttcatatca gcagggaaag gggcttcagc aactatgagc tcgtctgtta 995701 tcgggtgaac cgcttgtact ttattggcgt gcagtgcctg cctgtttagc agcttgctcc 995761 cgcctccgta aagcgagtct cctgtcaacg gatggccgag gctcgccaga tgaacacgga 995821 tttggtgtgt tctgcctgtt tccagctcta attcaacgag cgacagccgt tctttcgcat 995881 tgctggccat taccttgaaa tgagtgacgg ctgtttgccc gcctggtgaa acccggcgtc 995941 ttgtcgggtg tgagcggtct ctgccgatcg gtgaattaat tgtccctttt ttcgtccgta 996001 gcttaccttc agcgatagcg gtatacgtac gcttcagcgt ctttttctct aactgctggt 996061 ctaagatggc gtgtgccaaa cgatgcttgg caaaaacgat agcgccagat gtatcctgat 996121 caagacgatg gacgtggcgc accttacatg tttcgccatt tatctgataa tgatacgcga 996181 tcaaattagc cagtgtgccg gtttgcccat cctcattcgg atgcgtcgcg atgccagcgg 996241 gtttattgat gatgagcata tgattgtcct caaataaaat atcaagctcg ccatactccg 996301 gaatgaccga agatgcttca ctttcctgaa gatcaatgaa cacgcggtct ccctttttta 996361 caatcatatt gtttaagacg gattcgtgat tgacctttat ctgttgatgg gacatccagt 996421 cttgtatcac tggtttagaa gctttgagcg ctgttttgag tacggaaaac agccattggc 996481 cgtcctgttt ttcattgatg aggatctcaa gccctctgcc tttttggttc atgttaaatg 996541 gctccttttc gaagcggaag gctgctgttt ctcataggaa acacttacct tagctttcgc 996601 gtttttttct gtgctattct tgagtaagac ttaggatatt cgatggcaag aaaggtgatt 996661 gacgtgagaa ttgtgaacgc agcaactgca gaacaggaga gctttatcaa ggagctgtct 996721 atggagctga tccatgatgt atttcctctt tatttctccg aactggacat tcagcgcttt 996781 aaaaagaaag gcgttctgtc tttaaataac cattattacc aaggaacatt aaaagaagca 996841 tttcaaatta tggcttgtct gcaaatgata catattatcc tgaccaagcc ttcgccgcac 996901 tctgatttga gtgatcaggc gatttttgaa aaaaacagca agatgctgaa tgattttggg 996961 atttattttc cgtttgcttt ttctgacttt caaaagaaga ctaacaaagc ctttttcggt 997021 caaagaaggc tgatataatc atgcggcaag ggcttttcta tttttagaaa agctcttttt 997081 gtatcagaga aatcatatca taaaaccttt cctctaactc cctttttaaa cggctcgtgt 997141 ctgaacatac taatgattga aaggggtgct gacaatgagt tcagttaaag atacaatgac 997201 aacgcaggtg gcaaccgttt ctccgaatca aacgattcag gaagcggctt ctctaatgaa 997261 acagcataac gtcggggcga tccccgttgt agagcaaggt gttttaaaag gaatgctgac 997321 tgaccgtgac attgcattaa gaactacagc tcagggccgt gatggccaga cacccgtttc 997381 agaagtgatg tcaacagaac tcgtatcagg aaaccctaat atgagtctgg aagacgcgtc 997441 gcagctgatg gcccagcacc aaatccgccg ccttcctatt gtagatcaaa acaatctagt 997501 cgggatcgtt gcgcttggag acctggcagt caatcagatg tcgaacgagt ctgcgggatc 997561 agcgctgaca aacatttctc accaaaacat tcattaataa gaaagagctt gcagtgtgca 997621 ggctctttct tcacataaaa ccttactttt tgaaagcaga cttgtttcgg ggtatagtga 997681 gtgtatacat atgtctcaat tcgtactaaa ggagttgtac ccagtgatta aagcgttaat 997741 ttttgatttt gacgggctta ttctagatac agaaacacac gaatatgagg ttcttcagga 997801 aatatttgaa gagcacggct cagtgctgcc gctatctgtc tggggaaagg tcatcggaac 997861 tgctgcgggt ttccggcctt ttgaatattt agaagagcag atcgggaaaa agctgaacca 997921 tgaagagctc acacaattga gaagagagcg gtttgccaaa cgcatggaat cagaaaaagc 997981 gagacctggt gtcgaagcgt atttgaatgc ggcaaaggat ttaggcttaa aaataggcct 998041 tgcctccagc tctgattata aatgggtgtc cggccatttg aagcaaatcg gcctgtttga 998101 tgattttgaa gttattcaaa cggcggatga tgtggaagag gtgaagccga atcctgaact 998161 ctatttattg gcggcaaaga acctgggggt atcgccagcg gaatgtctcg cgtttgagga 998221 ttctgtcaat ggttcgattg ctgcgaaacg tgcaggcatg aagtgtgtca ttgtcccgaa 998281 taaagtaacg ggtaccttga tgtttgaaga ctatgatcac aggcttgaat caatggcgga 998341 gatggagctc gccctattgc ttgatcatct gaactcacaa aactagaaag gagcgagtag 998401 gttgtctgag aaattagatt tgacccggtt tgaaaagaaa atggttatcc gcaatatcga 998461 agagaaagac atcgacaaga ttatcgatct tcaaaaggac tgctttccag gaatggagcc 998521 ttggaagcgg gagcatttaa tcagccattt ggagcatttt ccggaaggac agttttgtgc 998581 agaattcgaa ggtgaaatta tcggttcgtg ctcaagtctc ctgattaact ttgatgaata 998641 tgatgaccgc catacgtggc aggacattac agatgacggt tatatcacca accataatcc 998701 tgacggcttg aatatgtacg gaattgaagt catggtgcac ccgaaataca gacgaatgaa 998761 gatcggccac cgtttgtacg aggcgagaaa ggacttagcc agacgcttaa acctgaaaag 998821 catcatcata ggcggacgga ttccaaacta tcacaaatat gcagaggaaa tgacagcgag 998881 agagtatgtt gaacaggtga cacgccacca aatttacgat ccggttcttt cttttcagct 998941 gatgaacggc tttaccctta tgcgaattaa cccgaactat ctcccggatg atacagcttc 999001 gatcaagtat gcgacgctga tggaatggaa taatgtcgat tatctaccgc agcagacaaa 999061 acgctattat aaatcggcgt tccctgttag aatttgtgtg atccaatacg aaatgaagaa 999121 aatttattcc tttgaggaat ttgcgaatca agtagaatac tatgtcgatg ttgcttccga 999181 cgcaagatct gattttgcgg tgttcccgga aattttcaca acccagctga tgtccttcct 999241 tgaggaacgg tcaccgagct tggcggtgca gagaattacc gagtatacag aagattacat 999301 cagcctgttt actgacttgg ctgtgaagta taacgtcaac attatcggcg gatctcattt 999361 cgtcgaagag gaaggcaaga tctataatat cgcttacctg ttcagacggg acggaacgat 999421 cgagaagcaa tacaaactcc atattacgcc gaatgaacgc aaatggtggg ggatcagcgc 999481 aggagaccaa gttcgcgtgt ttgatacgga ctgcgggaaa atcgcgatcc agatctgtta 999541 tgacattgaa tttcctgagc ttgcccggat tgcggctgat aaaggagcca aaatcatctt 999601 tacgccattt tgtacagaag accgtcaagg ctatctgcgt gtcagatact gttcgcaggc 999661 tagagcggtt gaaaatcaaa tttatacggt tatctctgga acggtcggaa accttccgca 999721 aacggaaaac atggatatcc aatacgccca gtcaggcatc tttgccccgt ctgattttga 999781 attcgcccga gacggcattg tcggcgaaac aaacccgaat attgaaatgg tcgtcatcgg 999841 cgatgttgac ctggaaattc tcagaagaca gcgccaaaac ggtacagtgc gccagctaaa 999901 agacagacga cgtgatattt atcatattca atataaaaaa taattcccaa aaaacccgcc 999961 tgaattggcg ggttttttta aacaaaagcg gaattgttta ggtgctttct ttaaaataaa 1000021 agtaaattgt atagtggatg tgccttatgg agtttctgta ttttcgccat ttcctatatc 1000081 atacagaaaa cggctaggct tcacattgct attgcaatgg ctgtccaagt tgtttcgagt 1000141 gcgaccttta tcagtacgat gctgagcatt gtcactttgc ctgttttgct ttggaagctg 1000201 catcctcttt cttcttgaga aaggggatgt tttattattt acgcggttta ttgactctga 1000261 cccggtctgg ctttatattg aaggcaggga aatcatcacc aagacatcac ataaagagaa 1000321 ggtctgtttc aattgaattg gcattatagg gaacgctaat gaaatggaga tgatggggat 1000381 ggaaaacatt cagcaaaatc agggattaaa gcaaaaagat gagcaatttg tgtggcatgc 1000441 catgaaggga gcgcatcaag cggacagcct gatagcccag aaggccgaag gggcctgggt 1000501 aaccgacaca gacggacgcc gctatttgga tgcgatgtcc ggtttgtggt gcgtcaacat 1000561 tggttacggc agaaaggagc ttgcggaggc tgcctatgag caactaaagg agctgcctta 1000621 ctacccgtta acgcaaagtc acgcacccgc aattcaactg gcggaaaagc tgaatgaatg 1000681 gcttggcggc gattatgtta tttttttttc caacagcgga tcggaagcaa acgaaactgc 1000741 ttttaaaatt gcccgccagt accatctgca aaacggcgac cacagccgtt ataaattcat 1000801 ctcaagatat cgggcatacc acggcaatac attgggagcg ctctcagcta ccggacaggc 1000861 gcagcggaaa tataaatacg agcctttgag ccaagggttc ctgcatgcag ctccgccaga 1000921 tatataccgg aatcctgatg atgcagacac gcttgaaagc gcaaatgaaa tcgaccgcat 1000981 catgacatgg gaattaagcg aaacgattgc cggggtcatt atggagccca tcattacagg 1001041 cggaggcatc ctaatgccgc cggacggata tatgaagaag gtggaggaca tttgccggcg 1001101 ccacggagcc cttttgattt gcgatgaagt gatctgcggg tttggacgga caggtgagcc 1001161 gttcgggttt atgcactacg gtgtgaagcc tgatatcatt acgatggcaa agggaatcac 1001221 aagcgcgtat ctgccattgt cagcgactgc tgtgaaacgg gacattttcg aagcgtatca 1001281 gggggaagct ccttatgacc gtttccgcca cgtgaacacg ttcggcggaa gcccggctgc 1001341 ctgtgctttg gcgttgaaaa acctgcaaat tatggaggac gaacagctga ttcagcgatc 1001401 ccgtgatctt ggagcaaagc ttttaggtga gcttcaagct ctgagagaac acccggcagt 1001461 cggggatgtt agaggaaaag ggctgctgat cggaatcgaa ctcgtcaaag acaaattgac 1001521 taaagagccg gctgatgccg ccaaagtaaa ccaagtggtt gcggcgtgca aagaaaaagg 1001581 gctgatcatc ggcaaaaacg gcgatacagt cgccggctac aacaatgtca tccagcttgc 1001641 gccgccattt tgcctgacag aagaggacct ttcctttatc gtgaaaacgg tgaaagaaag 1001701 ctttcaaacg atataatata aaagtgaatt attaaaggag cacatgatga gttttcacaa 1001761 ccagccgatc ttaccggcta ttcgcaatat gaagcaattt gatgagtttt tgaacagttc 1001821 attctcttac ggtgttattc ttgatattca tctcggccag ctgaagggcg tgatcaaaga 1001881 agcgcaaaag cacggaaaga acatgatggt gcacgtcgat ctcattcaag ggattaagca 1001941 tgacgaatac ggtgcggaat ttatatgtca ggatatcaag cccgctggga ttatttccac 1002001 aagatcgaat gtgattgcca aagcgaagca gaagaaaatt tatgccattc agcgcctgtt 1002061 tttgcttgat acaagcgcga tggagaaaag catggagttt atcggcaagc ataagcctga 1002121 cttcatcgaa gtgcttcccg gcatcgttcc gtcactcatt caggaaataa aagagaaaac 1002181 agggattccc atctttgccg ggggtttcat ccgtacggaa gaggatgtag agcaggcatt 1002241 gaaagcgggg gctgtagctg tcacaacatc taataccaaa ttgtggaaaa aatatgaaaa 1002301 ctttttgacg gaaagtgatt gacaccgctt tcatgcactg atacaattgc actaggttaa 1002361 tacattgtga tggagaactc ggagaccaca gcagctcttt acggcaaatg tttatgcacc 1002421 cgtaaagcgg tttgttgtgg tttttttatt ctcttcttct ctatcatgct ttttaatcgt 1002481 gactttagga ggaatgtgct atgacagcat tttggggaga agtcatcggt acgatgctgc 1002541 ttatcatttt tggtgcaggt gtttgtgcag gtgtcaattt aaagaaatcg ctttcattcc 1002601 agtctggctg gattgttgtt gtatttggat ggggattggg tgttgccatg gcggcatacg 1002661 cggttggcgg catcagcggt gcccatttga atccggcgct aacgatagcg cttgcatttg 1002721 taggagattt tccttggaaa gaggttccgg tttatattgc ggcgcaaatg atcggagcga 1002781 tcatcggtgc ggtgattatt tatctgcatt acctcccgca ctggaagtca acggatgatc 1002841 ccgctgccaa gctgggtgtt ttctcaacag ggcccagcat tccgcataca tttgcaaacg 1002901 ttttaagcga agtgattggg acatttgtcc ttgtacttgg aatcttggcc ataggtgcaa 1002961 atcaatttac agaaggactt aatcctttaa tcgtcggttt cctcattgta gcaatcggta 1003021 tttctctggg aggcaccacc ggctatgcta tcaatcctgc acgtgactta ggtccgcgga 1003081 tcgcccacgc ttttcttccg attccgggga agggctcatc aaactggaaa tacgcatggg 1003141 ttccggtagt cggcccgatt ttaggcggat cattcggcgg tgtattttac aacgctgcat 1003201 ttaaagggca catcacaagc agcttctgga ttgtaagcgt tatattggtt gtggtattgt 1003261 taggactcta tgtttatacg aaatcacatt ctgctaaaac attatcaaat tctaaatata 1003321 tttaatcaaa ggggagacat cttatggaaa cgtacatttt atccttagat caggggacga 1003381 caagttcaag agcgattctg tttaataaag aaggcaaaat tgtccactct gctcaaaagg 1003441 aatttacaca atacttcccg catcctggct gggttgagca taatgccaat gaaatttggg 1003501 gctctgtcct cgcggttatc gcctcagtca tctctgaatc aggaatcagc gcttctcaaa 1003561 ttgccggcat cggcatcacg aaccagcgcg agacgacggt tgtgtgggat aaagatacag 1003621 gaagtcctgt ctataatgca atcgtttggc agtccagaca gacgtccggc atttgtgagg 1003681 aacttcgtga aaaaggatat aatgataaat tcagagaaaa aacagggctt ttaatcgatc 1003741 cttacttctc cggcacgaag gtgaagtgga ttttagacaa tgtggaaggc gcaagagaaa 1003801 aagcggaaaa aggcgagctg ctgtttggaa cgattgatac gtggctcatt tggaaaatgt 1003861 caggcggaaa agcgcatgtg accgattact ccaatgcctc aagaacactg atgtttaata 1003921 tttacgattt aaaatgggac gatgaactgc tcgacattct aggcgtaccg aaatccatgc 1003981 tccctgaagt gaagccgtcc tctcatgtgt atgcggagac tgttgattat cacttcttcg 1004041 gaaaaaatat cccgattgct ggagcggcag gcgaccagca gtccgcattg ttcggccagg 1004101 catgctttga agaaggcatg gggaaaaaca cttacggcac aggatgtttc atgctgatga 1004161 ataccgggga aaaagcaatt aagtccgaac atgggctttt gacaacaatc gcttggggca 1004221 ttgacggaaa agtgaactat gcgttagaag ggagcatttt tgtcgcaggc tctgccatcc 1004281 agtggcttag agacggtttg agaatgttcc aggattcatc gctaagcgaa tcttatgcag 1004341 aaaaagtgga ttcaactgac ggcgtgtatg ttgttccagc atttgtcgga ctgggaacgc 1004401 cttactggga cagcgatgtg cgcggttcgg ttttcggcct gacaagaggg acaacaaaag 1004461 agcactttat ccgtgcgaca ctggagtcat tggcttatca gaccaaagat gtgcttgacg 1004521 caatggaagc agattcaaac atttcattaa agacgctccg tgtagacgga ggagctgtaa 1004581 aaaacaattt cctaatgcag ttccaaggag acctgttgaa tgttcctgtg gagcgcccgg 1004641 aaattaatga aacgactgca cttggcgcgg cttatttggc gggtatcgct gtgggattct 1004701 ggaaggaccg ttctgaaatc gcgaaccagt ggaatctgga taaacggttt gagcctgaat 1004761 tggaagaaga aaaacgaaat gagctgtata aaggctggca aaaagccgtg aaagcagcta 1004821 tggcttttaa ataaagtaat actatggtat aatggttaca agttaataag aacggtcctg 1004881 agatgaggag agaccacagc accaaagtgt aagcatgcac tttggctgtt gtggtctctt 1004941 tttctattta ccgtgacaac aaggaggaaa cgtaatgatg aatcatcaat tttcaagtct 1005001 tgaaagagat cgcatgctga cagacatgac gaaaaaaaca tatgacctat ttattatcgg 1005061 aggaggaatt acaggagccg gaacagctct tgacgcggca tcaaggggaa tgaaggtcgc 1005121 actaagcgaa atgcaggact ttgcggcggg aacatcaagc cgatcaacga agctggtaca 1005181 tggcggcttg cgctatttaa aacaatttga agtgaaaatg gtcgctgagg taggaaaaga 1005241 gcgggcgatt gtgtatgaaa acggcccgca tgtcactaca ccggaatgga tgctgcttcc 1005301 gtttcataaa ggcggcacat tcggttcatt tacaacatct attgggttaa gggtttatga 1005361 cttccttgca ggtgtgaaaa agtcagaacg aagaagcatg ctttcagcaa aagaaacgct 1005421 gcaaaaagag cctttggtga aaaaagacgg cttaaaaggc ggcgggtact atgtggaata 1005481 ccgcactgac gatgcgagac tgaccatcga agtcatgaag gaagcggtta aattcggggc 1005541 agagcctgtg aattactcca aagtgaagga gcttctttac gaaaaaggca aagccgtcgg 1005601 cgtattaatt gaagatgtgc tgacaaagaa agaatataaa gtgtatgcga aaaaaattgt 1005661 caatgctaca ggcccttggg tcgatcagct cagagaaaaa gaccattcga aaaacggaaa 1005721 gcatttgcag catacaaaag gcattcacct tgtatttgac cagtctgtct ttccgctgaa 1005781 acaggctgta tatttcgata cacctgatgg ccggatggta tttgcgattc ctcgtgaagg 1005841 caaaacatac gtgggaacaa cagacactgt ttacaaagag gcgctggagc atccgcggat 1005901 gacaacggag gatcgtgatt atgtcatcaa atcaatcaat tacatgttcc cggaactgaa 1005961 tatcactgcg aatgacatcg aatccagctg ggcggggctg cgtccgctga ttcatgaaga 1006021 aggcaaagat ccttctgaaa tttcacggaa agacgagatt tggacatctg actcaggcct 1006081 gatcaccatt gccggcggaa aactgactgg atacagaaaa atggcggagc acatcgttga 1006141 tcttgtccgt gatcgcttaa aagaagaggg cgaaaaggat tttggaccat gtaaaacgaa 1006201 aaacatgcca atctctggcg ggcacgtcgg cggttcgaaa aatcttatgt ccttcgttac 1006261 cgcgaaaaca aaagaaggaa ttgcagccgg tttatcagaa aaagacgcaa aacagcttgc 1006321 gatcagatac ggctctaacg tagatcgcgt ctttgaccgg gtagaagcgc tgaaagatga 1006381 ggccgcgaaa cgcaacattc cggttcatat tcttgctgag gcagaataca gtatagaaga 1006441 agagatgact gcaacccctg ctgacttctt tgtccgcaga acgggacgtt tattttttga 1006501 tatcaattgg gtaagaacat ataaagatgc cgttattgat tttatgagcg agcgattcca 1006561 atgggatgag caggcgaaaa acaaacatac agaaaacctc aacaagcttt tacacgatgc 1006621 ggtcgtaccg cttgagcaat aaatcataac gggctgtctg cagcccgtta tttcttttta 1006681 cgtgccgaaa gggggagatc tcaggttatc aagtgacaga ggcacccgct tcatataaaa 1006741 taatggcata agctgataca taggaggacg aatatgactt ggagaaagag ctatgaacgc 1006801 tggaaacaga cagaacattt agatctggaa ttaaaagagc gccttattga attagaggga 1006861 gatgaacagg cccttgagga ctgtttctat aaagaccttg aattcggtac cggcggaatg 1006921 cgcggggaaa tcggcgccgg gacaaatcgg atgaatattt acactgtgcg caaagcatcg 1006981 gccgggtttg cggcatacat ctcgaagcaa ggtgaggaag cgaaaaaacg gggcgttgtc 1007041 attgcttatg attcccgcca taagtctccg gagttcgcga tggaagcggc aaaaacactt 1007101 gcgacacaag gcatccaaac atacgtgttt gatgagcttc gcccgacgcc agagctgtca 1007161 ttcgctgtta gacagctgaa cgcttatggt ggaattgtgg taacggcaag ccataacccg 1007221 cctgaatata acggctacaa agtatacggg gatgatggcg gccagctgcc tccaaaggaa 1007281 gcggacatcg tcattgagca ggtaaacgcg attgaaaatg agctgacgat cacagtggac 1007341 gaagaaaata agttaaaaga aaaaggctta atcaaaatca tcggtgaaga tattgataaa 1007401 gtttatacag aaaaactgac gtccatttct gtacatcctg aattatcgga agaagtagat 1007461 gtaaaggttg ttttcacacc gctgcatgga actgcaaata aaccggtcag acgcggtctt 1007521 gaagcactcg gctacaaaaa tgtaacggtt gtcaaagaac aggaactgcc ggattcaaac 1007581 ttctccactg ttacatcgcc gaacccggaa gagcatgcgg cattcgaata tgccattaag 1007641 cttggggagg agcagaatgc agatattctc atcgcgacag atcctgatgc tgaccgcctc 1007701 ggcatcgcgg tgaaaaacga tcaaggcaaa tatacagtgc tgacaggaaa ccaaaccgga 1007761 gcgttgctgc ttcattacct gctttctgaa aagaaaaaac aaggcatcct gcctgataac 1007821 ggtgttgttc tcaaaacgat cgtcacaagc gaaatcggcc gtgctgtagc ttcttcattc 1007881 ggccttgata cgattgatac gctgacaggc tttaagttta tcggtgaaaa gattaaggaa 1007941 tacgaagcat caggccagta taccttccaa ttcggttatg aagagagcta cggttattta 1008001 atcggggatt ttgcccgcga taaggacgcc attcaggctg cgcttttggc agttgaagtt 1008061 tgcgcgttct ataaaaaaca gggaatgtca ttgtatgagg cgctcatcaa tctctttaac 1008121 gaatatggtt tttatcgtga agggctgaaa tccctgacgc tgaaaggcaa acaaggagca 1008181 gagcaaattg aagcgattct tgcttccttc agacaaaatc cgccgcagaa aatggcgggc 1008241 aaacaggttg tcacagcaga agattacgct gtaagcaaac ggacgcttct gactgaaagc 1008301 aaagaagaag ccatcgactt gccaaaatca aatgtattga aatacttcct ggaagacggg 1008361 tcttggttct gtctccgtcc ttctggaact gagccgaagg ttaaatttta tttcgccgta 1008421 aaagggtcat ctttggaaga cagtgaaaag cgacttgccg tcctttctga agatgtaatg 1008481 aagacggtgg atgaaattgt tgagtcaaca gcaaaataat tcaagtatga gctgggtcat 1008541 tgtaaatgat ccggcttttt ctttttctca tccaaaagtc tgaaagaaaa tcatcctaca 1008601 agtgaagcaa tgaaatacaa aaaactggta taatcttaaa tacaagatca atgccggagt 1008661 gagaaacgtg agcaaaacga ggatggaaaa attaaaaacg ctgaaaacga ttgcggaaac 1008721 cttaaatcaa gggcacgata tcaaagcaac actggatgag gttttaaaag agttgctgag 1008781 tctgacaaac cttcaatccg gatggatttt tctgatcgaa gaagatgggt cttatacgtt 1008841 agcggccgac gcttatctgc ccccggcttt aagccgcaag gaaaaagtgc tgatgtgcga 1008901 aggggagtgt tactgcctga cgaaattcaa taacggaggg cttagaaaag ctgcaaatat 1008961 catgaactgc aaacgcatcg aatcagcaga aaacctgcat tgttttgaca cagaagggat 1009021 tacgcatcat gcaactgtgc ctttagaaga cggggacaga agattcggat tgttaaatgt 1009081 agcggcggcc ggaaaaacca tgtttgatga ggaagagctg catttactcg agtctgtcgc 1009141 ctttcagatc ggaacggcaa tccagcgtat gaggctttct gaatatcaac aaaaaaatgc 1009201 tcttttaatg gagcgtaacc gcctcgctca ggagcttcac gattcagtca atcaaatgct 1009261 gttttccgtc agtttaactg ccaaagctgc gaagacacta acaaaagatg aaaatttaca 1009321 gcagatgatt gatttcatcc aaaacctatc acaggacgcg ctcgcagaaa tgaaagcgtt 1009381 aatttggcag cttcgccccg gaggattgga aaaagggctg gctgaagcca ttaaaagcta 1009441 tggtgcgctc attggattga agatcatttt tacacaaaaa ggctgtcctg ttctgactga 1009501 tgagcaggag catatgctat ggcgtgtcgt acaggaagct ttaaataact gcaaaaagca 1009561 tgccggaacg gatacggcgt atgttagtct gactgcttct ttgtgccatg cggagctgga 1009621 tatcatcgat catggggcag gatttcgcta tgaagcgcat gccggtctgc cttcacttgg 1009681 cataaaaggt atgaaagagc gagcggaaaa agccggagct aagttttgga ttgagtcagc 1009741 gcttggaact ggaacaaagc tgtccatcag gcttccgcta aaaagccgaa aaggaggggc 1009801 ggtatgaaaa ttgtcattgc tgatgatcat catgttgtca gaaagggtct gcgttttttc 1009861 tttgccaccc aggatgatat tgaagtcgtc ggagaagctg caactggatt agaagccctc 1009921 cgtgtcatcg aagagacaaa gccggatctt gtgctaatgg atttgtctat gcccgagatg 1009981 gacggcattc aagccattaa aaaagcaata cagcaatttc cggatacgaa tatcattgtg 1010041 ctgacgagct actctgatca ggagcacgtc atccccgcgc ttcaggcagg cgcgaaggcg 1010101 tatcaattaa aggatacgga gcccgaggaa ttggtgaaaa cacgacaagt gcatggtggc 1010161 gaatacaagc tttctacagc tattatgccc catgtgctga cacatatgaa aaatcagcac 1010221 gacccggaaa aagaaaaata ctatcaatta actagaaggg aaaaagacgt tctgactgaa 1010281 atagcgaacg ggaaaagcaa taaagaaatc gcagcagcct tgtttatttc agaaaaaaca 1010341 gtaaaaaccc atgtatcgaa tcttttagca aaacttgaag tggccgatcg cacgcaagca 1010401 gcgcttttcg cagtgaaata taacctgaat ggagagatct caaaatgaac atgttagtca 1010461 taaatggcac gccaagaaaa catggcagaa caagaattgc agcatcctat attgcagctc 1010521 tgtatcacac ggatttgatt gatctaagcg agtttgtatt gcccgttttt aacggtgaag 1010581 cggaacaatc tgaactgttg aaagtacagg agcttaagca acgcgttacg aaagcggatg 1010641 cgattgtatt attatcgcct gaatatcaca gcggcatgag cggcgcttta aaaaatgcct 1010701 tggattttct aagcagcgaa caattcaaat ataagcccgt tgcattattg gcagtagcgg 1010761 gaggcggaaa aggcggcatc aatgcgctga acaatatgag aactgtgatg cggggtgtct 1010821 acgccaatgt cattccgaag cagctggtgc ttgatccggt gcatattgat gttgaaaatg 1010881 ctacagtggc tgaaaacatt aaggaaagca taaaagagct tgtcgaagaa ctcagcatgt 1010941 tcgcaaaagc aggaaatccc ggcgtctaaa cgccgggatt tgtttatgtg agaagggcta 1011001 tttgatcttc ataagtcagc tctgtggcat gatcaatata tcggagaagg gaatacagca 1011061 tcttttctaa aacggcgtaa tcctgttcaa aatgatacgc atgcagaaaa tgctcaattc 1011121 gttttgataa caaatcgtcc tctgtacgca ccattaaaat taataaatta tcccattgag 1011181 aacgatgggt gtaataaagc gctttatcgt aatcggcata atccatgaat cgcttctcct 1011241 ttcttgggtg agaagttcat gattagttta tgccgcatcc tctgttattg acggggcaaa 1011301 acttgccgtc tgcgtcagta aaggggtagc aatatgaggg agacataaaa tcaaaatgcc 1011361 tgaatgaaga tatcgctttt ggtaaaccta tgagggaata tattctgggt acaggagact 1011421 gaaaaaatga aatccctgcc gtataccatc gcacttcttt tttgcggatt gattatcgtg 1011481 tcaatggctg caaaaggtca ttcaacggac acagacgagt ccgttcaaaa gtgggaacag 1011541 cttgcctgga gcaaaattca ggatgaatat aagggcgctt cattttctga ttatgcttat 1011601 atggggcgta cagaggtgaa tgatcagcag actaaagatg tctttcgggt gacagtcaga 1011661 cagaaagatg acactttttc tgttcgggcc gaagtctatt ttcatccggt gacaaatcat 1011721 atgatcagca tcaacgtctt taggctctaa taaaaaactg tacagccgtt aaggccgcac 1011781 agtttctgtt tttagaaata tcgttttgca ccgagatagc gctgtttcca gtaagagttg 1011841 ttcatattgg aaatgacaac tccggaatcg ttggcattta tgaattcccc gttgcctagg 1011901 taaattccga cgtgggaagg gccggcttta tatgttgaaa agaaaacgaa atctccgaca 1011961 gcaggctggc taactgattt cattgtgttc caatatcccg ctgccgttaa tctagatacg 1012021 gatgtgactt tgttcagtac atagtaaatg aatccgctgc agtcaaaccc ggacggtgtc 1012081 gtgcctcccc agcgatacgg aaccccaagc tgcgctttag cggccgaaat cattgtgtta 1012141 atcttcgcac tcgttgagct ggtggtgttt gaagaaccgg atgaagacga tgatgaagct 1012201 tttccggaaa tgaccagctt ttggccaacc tgcaagacat ccgtttttaa attgtttttc 1012261 tcacgaatct gctgagctgt tacattaaat ttttgagcaa tcacccataa ggaatcaccg 1012321 cttttcaccg tgtatgtagt cgtcgtgccg gagcttgcat ttgacgaaga agacgacgat 1012381 gatgaagagc ctgaagatgc tttacctgtc agcttcaata cttgtccaac gtaaagcaca 1012441 tctgatttca gattgttgat atttcggatt tgctgtacag tcaggttata gttgtttgcg 1012501 attttccaaa gtgaatcacc gcttttaacg gtatatttag ttgttgctga agtttggttc 1012561 gatttggatg aattgtcttt agaagacgta tcagagccgc ttgattttgt tttcaacacc 1012621 tgattcacgt aaatggtgtc tgattttaag ttgttcaaga ccttcaattc agcgatggac 1012681 atattgactt tgtttgcaat tttccaaagt gaatctccaa gctgcacctt atatgttccc 1012741 gtagaagatg aagaacttga actcttatta gaactgcttt ttgaactgga gcttgaactc 1012801 ttattagagt tgcttttttt actggaacta gagcttgaag aaacagtacc ggacaccttt 1012861 aatttctgcc cagcacgaat taaatcgctg cttagtccgt ttaatttttt cagttcctgc 1012921 accgtcattt taaactcatt tgcgatcagc caaagtgaat ctccgctttt cactgtgtaa 1012981 acagaacttc cgctcttctt ggttgttgag cttgaagtag atgaagaagt gctggatttg 1013041 ctgcctggaa tagtaagcgt ctggccgatc gacagaacag tagtcgaaag atgattggcg 1013101 gatgtgaggg ccgccacact tgtgttatag gtttgggcca gtttccataa agaatctccg 1013161 cttttgacct taatcgttgc tgcttcagct ggtgtcacta ctaaagttgt gccgacaatc 1013221 gcagatgctg tcagccctgc tgctaatttc tttttcatct tagctctcct ttttccccca 1013281 atgattttgc atttgctgtt tcttttttat atcggcacat ttgtctcatc gttttgcctt 1013341 tttataaaaa tagccaaatt atcttaacaa taagggggaa aaagggcata aaaaaagaag 1013401 gaatcttaat ctattccttc atttttaaaa gcttcatgat atcttctttg tttttgacga 1013461 ggtcgcgcag tgtgtatttg tctaaaactg cgaggtaggc taaaagcgct tcattcagca 1013521 catgttttaa gccgcaaacc ggggaaataa cacagagatt cttgttcgca tcaaaacatt 1013581 caacaatatt aaaatcgtcc tccgtttttc tgacaacctc accgatgttg atgtcttcag 1013641 ggtccatgcc taatcgtatg ccgccgcccc gtccgcgtat cgtttctacg tagccgagct 1013701 ggccgagcct gtatatgact ttcatgagat gattttttga aatagaatac gtttcggcaa 1013761 tctgttttat atttgaaagt tctccgggac gctctgcagc cagaaaaatc aacactctta 1013821 atgaataatc tgtataattg gttaacttca taataagacc tcagaataag acattttcta 1013881 tatcttatca taatcgattg aaaaatgaaa aaaaaggaat taaaaaacat gcacccagct 1013941 gggtgcatgt tttttgctta catgtcattc ggcggatttt ggtttttacg gtttttttcg 1014001 atttctgtgt tttgcatttt gcgttcaaat gtagacagat aacgtgatgc aaaatcctta 1014061 ccgccaaggc cgaaggataa accaaaagca agtgcgaagc cgctaagaac gatgatgaac 1014121 gcggaattga cgattgtcgc agcgacaccc agctgatcca gggccataaa gaaagcaagt 1014181 gcgataatcg tatatttagc aataggcgct aaagacttga attcctgacc ttttatcatg 1014241 cttgcgagca cttttctcac caattctcct gcgtaaaggc cgagtccgag aatgaatact 1014301 gcgacaagga cattcggcag atacgcgatg atgccggtgg caatttctac gaggaagtgc 1014361 agccgaacaa tttgaagcgc ctcagctgta aagagcagaa tgacaatgat ttgcgcaatc 1014421 ataccgacaa cttgagacaa ggacagcttt gcaggcgttc cggcttccat gcccattttc 1014481 cctaagacag aatcaaagcc tgcgcgatgg agcagtccgg acaccatgga tttcacccat 1014541 tttcctgccc agatacccgc taatacaagc acgatggcaa tcatgatgtt cggaagcatg 1014601 tttaaaatcg tattcagcat agagacagct ggttttgaaa tgccggcgac atccagctga 1014661 tcaagcgctg aaatgaccac cggaatcata atgagcacat aagcgattgt tccgatgact 1014721 gctgaaaggc ttgtgtcttt taagtaaatt gataaaccca tacgtgccgc gaatctttcg 1014781 gtgccgatgc ttgcaaggaa attcgtaatg atatcacgga caaggcgggc aacaagccat 1014841 ccgattaata cgataagcgc cgctgcaaat aatttcggca gaaaagcgag cacgctttcc 1014901 atcatatttg taaaaggacc tgaaatgccg ctgattttca aagaagataa gacccctggc 1014961 agaaaaacaa gcagcacgag ataaaagaca atttgtgaag cggtattgac agcctggtga 1015021 atatcttttc cttcagacac caaattccac ttgcgcagtt tgtcactcgt gttcagcttc 1015081 atcccgattt ttttgacaag gaagctcaaa acagaagctg cagcccatcc taacagcaga 1015141 atgagtccgg ctttcagcac gcttgggatc gcagctgcaa tcgccgaaag catactgaca 1015201 aacggcgatg ccactgttgt caggtgcaaa atgttaaaga ataaaataaa gacgatgatc 1015261 agtgcgataa aataaacgac cttgcttatg actttttccg aggaatagcg tgaaggcttt 1015321 ttcccagcaa agagcttgtc gtcgattttt gttttgctga gtcctttgta taccgctttt 1015381 tcaatgattt tagcaatagc ccagccgatt aataagacga gtaaagcaat gattacgttt 1015441 ggcagcttac tgagataaga agaaaacacg tctgctacat tcaattggta tcgctccttt 1015501 ttcgtagtat ggtgtgtgtt tacccactta tccaataagc aaacagatga atgtgccggg 1015561 ggaatttttt cttgcccgag tgagactatc atcttttgtc tggcgggctc atacattata 1015621 gataagtcca agtagggggg attcggttga acgcggagga gaagaaggga ttacagcggg 1015681 caattgagga aattaccgaa attgcaaaag gattcggcct tgatttctac ccgatgagat 1015741 atgaaatctg cccggctgaa attatttata catttggcgc gtacgggatg ccgacaagat 1015801 tcagccactg gagcttcggc aagcagtttc acaagatgaa gctgcactat gatctagggt 1015861 taagtaagat ctatgagctg gtcattaact cagatccatg ctacgctttt ttgctggaca 1015921 gcaactcact gatccaaaat aaattgattg tcgcacacgt tcttgctcat tgcgatttct 1015981 tcaaaaacaa ctgccgtttc caaaacacga agcgcgatat ggtggaaagc atggcggcaa 1016041 cagctgaacg gataaaacac tatgaacagg ttcacgggat aaaagaagtc gaatcttttt 1016101 tagatgcaat cctttcgatt caggagcata tcgatccgtc gttggtccga ccaaagctcc 1016161 aatggagtgt ggatgatgag gaagaggaga ttgaagaggc agccacgcct tacgatgatc 1016221 tatggtcttt agatgaaaag aaaccgaaaa aacaagtgaa aaaatcgaaa aaaccgttcc 1016281 cgccgcggcc tgaaaaagat atcctgcttt ttatcgagga gcattcccgg gagctggagc 1016341 catggcagcg tgatatatta acgatgatga gagaggaaat gctttatttc tggcctcagc 1016401 tggaaaccaa gattatgaat gagggctggg cttcctattg gcaccagaga attatacgtg 1016461 agcttgattt aacctctgat gaagcgatcg agttcgccaa gctgaatgca ggtgtcgttc 1016521 agccgtccaa aacaggcatt aatccttatt atttagggct gaaaatattt gaagacattg 1016581 aaaagaggta caacaacccg acggaggaaa tgaagaaaat gggcgtgcag cctgactccg 1016641 gccgggagaa aatgtttgag gtcagggaga ttgaatccga tatctctttc atccgcaatt 1016701 atttaaccaa agaattagtc atgcgcgagg atctttattt gtttcaaaaa cagggccgag 1016761 attataaaat catcgataaa cagtggaagt cggtgcgcga ccagctcgta agcatgcggg 1016821 taaatggcgg ttttccatat ttgacagtaa acgacggcga ttatatgaaa aataacgaac 1016881 tctatattaa gcattggtat gagggcatag agttggattt gaaatatttg gagaaagtgc 1016941 ttccttattt attccagctt tggggaagaa gcgtgcacat tgagtctgtg cttgaggata 1017001 aggaagtcat gttttcgtac gacggaaaag gtgttcaccg cagatattta taaaaaagag 1017061 gatgcagcgt tctgcatcct ttttattttc cagtttttaa aatcttaaat atgatgtttg 1017121 cctggtccgt attgttaatc aatccgcgga atttttcttt tccggggccg tacgcgtata 1017181 ccggtacttc ttcgccggta tgatcggtac tcgtccatcc gctgttggag cgggtattaa 1017241 aaatcttgat gatggctttg gaggcccctt tgcttttgtc agcctgtgca gctgcttcaa 1017301 cgcttttgat ttcttcagat gtgactttca gattggcata gcgggcgagc acatctttaa 1017361 ccggcttgcc ttcactgatt tttttggcca tgaattcagg tgttttctta gcggagagaa 1017421 tcggttctgc gtgccaattc ttttccccgt ttgcgccaat ggtaaagccg ccggttgtat 1017481 ggtcagcagt tgcaatcaca agtgtatgtt tgtctttttt cgcaaattca atcgcggctt 1017541 tataggcctg ttcaaaatct ttaacctcgc tcatggctcc tactgtatca ttgtcatggg 1017601 ccgcccagtc aatctggctc ccttcgacca tcaagaaaaa tcctttttta ttttggttca 1017661 ggcgatcaat tgctgaaacc gtcatgtctt tgagagacgg tgttttactg tcacggtcga 1017721 gcgctttagc aagccctcca tctgcgaaaa gcccgagcac ctgctgatct ttattttttt 1017781 tcaatgcttg tttagttgtc acatagctgt agccggcttg tttgaattcc tttgtcaagt 1017841 ttctgtcctt gcggttaaaa taagattttc cgccgccgag cagcacgtct attttatgtt 1017901 tgccttttat cttgtcatcc atatagctgt tggcgatttg gtccatgttt ttccgtgatt 1017961 cattgtgggc gccatatgcg gctggagtgg cgtggttaat ttcagacgtg gcgacaagcc 1018021 ctgttgactt gccttgctgt ttggcctctt caagtacaga tttcactttt tttccgtttt 1018081 tatcgacgcc aattgcattg ttatatgtct taacgcctgt cgctaatgct gttccggctg 1018141 ctgctgaatc tgtaatatta tagtcagggt catccggatg cgtcatcatc atgcctgtca 1018201 ggttccggtc aaattctgtt aacttcgggt tattcggtgt gtcaccgtta tttttcatgg 1018261 aacggtaggc tcttatgtaa ggcgtcccca tgccgtcgcc tatcatcaca atgacatttc 1018321 tgatctcagc tttgtcttgt tttttggcgc tggccttttc tgtttgctga agctcagctc 1018381 cggcaaagat tccagctgta aggacagaaa cagcggcgat tggcagaagt tttgatttca 1018441 tattttgaaa caaactcatt tttttcatgc ctcctttaat gtattccgtt tatcatgtta 1018501 gggaaacttt gttaaatgcg gctgttgatc atgtaaacaa taagtaaagc cttgtaagga 1018561 aatgaaaaaa cgcttttcgt tatcttgcct tatttgatgt aaagcattca tttttcagaa 1018621 aaatctttac ctctctgtct ttgcatgata tgtttgttta aataaaaaaa ctgcggataa 1018681 ccacagctct cctcgaatat actttatcac tcatttttcc gatatatgag ccgaccccga 1018741 aagtttttca tttatttcct ttatgttgaa aaacatccca taaaacatga caaaagcact 1018801 cgttttttgt cacctttgca atgaaaatga aatatttaat acccttaaaa actttttttt 1018861 agaacgaata attaagaaat ttgtcacatg aagtcaagac tatttctgat gggaatctat 1018921 ccttataata gaaatcaata agattaattt aaaaaaagag atacatatat atagagttaa 1018981 catttgggga ggaaaatatg aaaaagcaaa tcattacagc tacgacagca gttgttttag 1019041 gatcgacgtt atttgcagga gcggcatctg cacaaagcat taaggtgaaa aaaggcgaca 1019101 cgttatggga tctttcaaga aaatacgaca caacgatcag taaaattaaa tcagagaacc 1019161 accttcgttc agacattatt tatgtgggac aaactttatc gattaacggc aaatctacaa 1019221 gttcaaaaag cagcagttct tcttcctctt cttctacata caaagtaaag agcggggaca 1019281 gcctttggaa aatttcaaaa aaatacggca tgacaatcaa tgaactgaag aagctgaatg 1019341 gcttaaaatc agatttgctt cgtgttggac aagtcctgaa actgaaaggt tcaactagtt 1019401 caagcagctc cagctcatca aaagtgtcat cgtcttcaac ttctacttat aaagtgaaga 1019461 gcggagacag cctttctaaa attgcgagca aatacggcac tacggttagc aaattaaaaa 1019521 gcttaaacgg cttaaaatca gatgtaatct atgtcaacca agtattgaag gtgaaaggaa 1019581 caagcacaag cagctcaaaa cctgcttcat cttcatcgtc ttcaagcagc aaaacgtcat 1019641 ctacatcact taatgtgagc aagctggttt ctgatgcaaa agcgttagtc ggaacgccat 1019701 ataaatgggg cggaacgaca acttcaggct ttgactgcag cggattcatt tggtacgtac 1019761 tgaataaaca aacaagtgtg ggcagaacaa gcactgcagg atactggagt tctatgaaga 1019821 gcattgccag cccgtctgtt ggtgatttcg tcttcttcac aacatataaa tccggccctt 1019881 ctcacatggg gatttacatt ggaaacaaca gtttcattca tgcaggatct gacggcgtac 1019941 aaatcagcag cctgaacaac agctactgga agcctcgtta cctcggtgcg aaaagattct 1020001 aatttttaga gaaaacccgt tcattggaac gggttttttt cattagacgg agcacaggcg 1020061 ttttggttgc tcctaaaaat gaaaatgtga taaaaaatcc aagaactttt tttctttctt 1020121 attttcataa agggcaatcg cgtaagcgcc ggcatagggc agctgtacag actgataagg 1020181 aattctgatc atctgtttct ctgctaactc acgctttact gtagataaag gcagaaatga 1020241 aactccgagt ccttccttga taaaccgttt cgttatatgt gtttgagtga ccttcattgt 1020301 tctcacaaat ggaaatgtca ttctgacttg acggagcaag tcgtcccagt aatcaggatg 1020361 attgtgggtc aaaagcaggt attgttcgag cacctctttg gcatcaattt cgttgtcttc 1020421 tatgaaacgc ttatcgggcg gggcaacaag gacgacaggg tctttgtata agcagtggca 1020481 gcttaaagaa gaagactgta cctttaaaca gcttagtccg atatctgctt ccccggcttt 1020541 aatcagtgac gcgatttccg ctgattcgaa aatcgtaacc gccatttctg tttccgtatt 1020601 cattgctgtg taccgcttca tgacagaagg aagcactgta tctgcaataa gcggagaaac 1020661 cgcgagctgt aaggtttgag agtagccttg tctcactctg tgaagctctg ccatgctgtt 1020721 ttcataatca tcaagaagcc tgagcgcata cggcaaatac gccctgcctt catcagtcag 1020781 ctggatttgc ctgcctttac gctcgaacag cttgcagctg atttcttttt ctaattgctt 1020841 gatatgtacg gtcacagtag gctgagataa gaaaagcgtt tccgccgttt ttcggaagtt 1020901 ctcatatttt gcagcggtca caaaggtgtg aagccatttg aaatccattt ctattctccc 1020961 tctgattaat atttttaatt aattcccttt aaaatattga ttatttttta aatattatat 1021021 ttactataat aacagaaaag gataggggga atacaaatgg tacattacgg attaaaggga 1021081 attacatgtg tagaaacatc catcagccat attgatggtg aaaaagggcg tctgatttac 1021141 agaggacatc atgcaaaaga catcgcactg aatcacagct ttgaagaagc ggcttatttg 1021201 attttatttg gaaaactgcc ttcaactgaa gaattgcagg tatttaaaga taagctggct 1021261 gcggaacgga atcttccgga acatattgag cgcttgattc aatcactgcc aaacaacatg 1021321 gacgatatgt cggtgctgag aacggttgtt tcagcattgg gggaaaatac gtacacattc 1021381 catccgaaaa cagaggaagc aatccggctg attgcaatca cgccttctat cattgcatac 1021441 agaaaaagat ggacgcgcgg tgaacaagca attgcacctt cttcccagta cggacatgtc 1021501 gaaaactact attatatgct cacaggtgaa cagccttcag aggcaaaaaa gaaagcgctt 1021561 gaaacctata tgattctggc cacggagcac ggcatgaacg catcgacttt ttcggcacga 1021621 gtcacgttat ctacagagag tgatttagtg tcagccgtca cggctgctct cggtacgatg 1021681 aaaggtccgc tgcacggagg tgctccttct gcggtgacaa aaatgcttga agacattgga 1021741 gaaaaggaac atgctgaagc atatctgaaa gaaaaactcg aaaaaggaga gcgcttgatg 1021801 ggattcggcc acagggtgta caaaacaaaa gacccgcggg cagaagcttt gagacagaaa 1021861 gcagaagagg tggccggcaa tgaccgtgat cttgatcttg cgctgcatgt agaagcagaa 1021921 gcgattcgtt tgctagaaat ctacaaaccg ggacgaaagc tgtacacaaa tgttgaattt 1021981 tacgcagctg cagtgatgag ggccatcgat tttgacgatg aattgtttac tccgaccttt 1022041 tcagcaagcc gaatggtagg gtggtgcgcc catgtactgg aacaggcaga aaacaacatg 1022101 attttccgcc cgtcagcgca atataccggt gccattcccg aggaagttct ttcataacat 1022161 attttggcgt ttattcattt ctgtcgtgtg gtaacgttca gtatcaacca catgtctagg 1022221 agtgatgaat gtgaacccaa tggacagaca aacagaagga caagaaccgc agcatcagga 1022281 cagacagccg ggcattgagt caaaaatgaa tccgctgccg ctgtcagagg acgaggatta 1022341 tcgaggaagc ggaaaactga aaggaaaagt tgcgatcatt actggaggcg acagcggaat 1022401 agggagagca gcagctattg cctttgctaa agagggggct gatatctcca ttctatactt 1022461 agacgagcat tcggacgcag aggaaacacg caaacggatc gaaaaggaga atgtccgctg 1022521 cctgcttatc ccgggagatg ttggggacga gaaccattgt gaacaagctg tgcagcaaac 1022581 agtggaccat tttggtaaac tcgatatctt agtgaacaac gccgctgaac agcatcccca 1022641 ggacagcatt ctcaatattt caacagaaca gctggaaaaa acctttcgca caaatatttt 1022701 ttccatgttt catatgacga agaaagcttt gcctcacctg caagaggggt gtgccattat 1022761 taatacgaca tcgattaccg cttatgaagg ggatacggcg ttaattgatt attccagcac 1022821 aaagggtgcg attgtttcct ttacgcgttc catggcgaag tcgcttgcag ataaaggcat 1022881 cagagtgaat gcggtggcgc ccggtccgat ttggacaccg cttattccgg cgacattccc 1022941 tgaggaaaaa gtgaaacagc acggcttgga taccccaatg ggaagaccgg gacagccggt 1023001 tgagcatgca ggcgcctatg ttctgctggc gtctgacgaa tcttcctata tgacagggca 1023061 gaccattcat gtgaatggcg gccgttttat ttcaacgtaa tcaacgaaaa accagctcaa 1023121 gagctggttt tttgtgtggt gaaaaatttc aaaataaaaa atttgtcgat ttttctaaca 1023181 attttgtttt catttttgca attttatata taatattgag taggagaaag gaatgattcg 1023241 cgaccagtac aaatatagta gaaaaaaaag aataatgacc attgttactc atgaattcag 1023301 aaaattcaaa taaaatatat aaaaatagat gatcgggagt tgaaggggaa tgaaagggag 1023361 cgtttttagg aagaaaagca ttcaggattt aatcgctgcg acgagcgggg aaaagtcttt 1023421 aaaaagagaa ttaggggcat ttgatttaac gttgcttgga atcggcgcca ttattggcac 1023481 agggattttt gttctgacgg gaacaggcgc agtcacggcc ggtcccgggc tgacgatttc 1023541 atttgttgtg gcggcgttgg cttgtttatt cgccgccctg tcttacgcgg aatttgcgtc 1023601 aagtgtgcct gtttcaggtt cggtgtatac attcacttat gcgacattgg gagagcttat 1023661 ggcctttatt atcgggtggg atttaatttt agaatacatg ctggcggtaa gtgcagtgtc 1023721 ggtcggctgg tctggttatt tccaatcgtt tttatcaggg cttggcattc atcttccggt 1023781 tgctttaaca gcggcaccgg gcgcagtgaa aggcaccttt accctgttta atcttcctgc 1023841 attcgtcatt gtaatggcga tcacatattt gctttattta ggcatcaaag aatcaaaaag 1023901 agtcaacaat atcatggtta tcttgaagat actggttgtt ctgctgttta tcgcggtggc 1023961 agccgtttac gtgaagccgc acaactggca gccgtttatg ccaatgggct ttggcggcgt 1024021 gttcagtgca gcggcgctcg tattctttgc ttttatcgga tttgacgctg tatcctctgc 1024081 tgcggaagaa acgaaaaatc ccgcgaagga tctgcctaaa ggcattattt tctctttact 1024141 ggtctgcacg attttatatg tcaccgtatc agccatcatg actggggtta tcccgtttgc 1024201 tcaatttgcg ggtgtggatc atccggtttc tcttgttctt caaagcgcag ggcaaaattg 1024261 ggtggcaggc atcattgata ttggcgccgt gttgggaatg acaacagtta tgctcgtgat 1024321 gctttacggg cagacccgcg tcatgtttgc catgtcgcgt gacggacttg tgccgggttc 1024381 actttctaaa gtgcatccaa agcacaaaac accttatgta gccacttggt ttttcggaac 1024441 gatgtcggcg cttctcggct cacttgttcc gctggatgaa cttgcaaagc tggtgaacat 1024501 cgggacgttg tcggcatttg tcctgatttc tgtggcagtt atcgttttga gaaagaaaca 1024561 gcctgatctt ccgagagctt ttaaatgccc gggagttccc gtgatcccag gcctggcgat 1024621 tctgttctgc ctgttcttga ttttaaatct gggatgggtg acgattgtcc gcttcctagt 1024681 gtggctgtta atcggcttgg taatctattt cctgtattca agaaagcatt caaaattaaa 1024741 tcaataacct tttgataaag agagcggcca tacaggccgc ctcttttctg ttcttggcaa 1024801 atgaatctat agaaatgaag acaaaaataa gagataatat aggctggaaa ggaagtgacg 1024861 tttattgtct gagcaaaaac cagtccaatg ggcttcgaaa attggtttcg tcatggcagc 1024921 ggccggctcg gctatcggct tgggcgcgat ttggaagttc ccttacgtag cggggaccaa 1024981 tgggggagga gccttttttc ttatcttcgt gttatttacc atcctcttag gctatccgct 1025041 tttggtgggg gaatttattt ttggaagacg gaaccagacg aatgccattg atgcatataa 1025101 aaaagaagcg ccgcgatcag cttggtttct tacggggtgg atcggcgtag cggcgtgttt 1025161 cttagtgctg tcgttttaca gtgtaatcgg gggatggatt ttgctgtata tcgtgaaaac 1025221 agcgtcagga tcactgtccg ggctttctca agcacagtat ggcgctcttt ttgcttctat 1025281 tatccaaaat ccggtgcaga cgctcgcggc tcagcttgtc tttatggcac tgactgtact 1025341 cgttgtcgca agaggggttc aaaaagggat tgaacgggta agcgcggtga tgatgccgat 1025401 tttgttttta ttgtttattc tgctcgttct tcggtctctt acgcttaatg gtgcaatgga 1025461 aggcgtaaag tttctgcttg tgcctcattt cggcgatctg actccggaat ccatattatt 1025521 cgcgctggga caggccttct ttacgttaac actgggggtt tcggtgatgg tgacctacag 1025581 ctcctatttg ccgaaaacac aaaatatccc tcgttcggca gcctccattg tcttgatgaa 1025641 tatcattgtg acactcttgg caggtttggc tatttttccg gcggttttct cattcggttt 1025701 tcagccaaat gaaggaccga cattgctgtt tacagtgctt ccggccgttt ttgaacagct 1025761 tccgttcggc acattgtttt ttatcggctt tctcgttgca tttttatttg cagccttaac 1025821 ctcagcattt tcgatggttg aaattatcgt tgccacaatc ggaaaagggg acgaaaagaa 1025881 gagaaaaaaa ctgtcatgga cgagcgggct tttgatcttt ttggtcggaa tcccatgctg 1025941 cttgtcttat ggcgttttga gtgatgtgca cctatttggc aaaacgtttt ttgatattgc 1026001 cgattttacc gtcagcaatg ttttgatgcc ttcaggcgct ctgttaattt ctctatttat 1026061 cccgctgaaa atttcgaaaa gcgaactctt ggctgaaatg cgaaatggat caaatgcagg 1026121 taaagcattc ttttacacat ggttttattt gcttcgtttt atcgtgccgc ttgccattat 1026181 tatcgtgttc ttaaatttaa tcggaatttt atcattttaa aaaacaggct ccgtttccgg 1026241 ggcctgtttt ttatttaata agatgatatc aacggtgccc atgccgtttt cagtttttgg 1026301 atgccgagcc tgatgtcctc ttctgacaaa ccgccataac cgattaagac agaagtaaaa 1026361 ggcgtctgtt ctatatatga gggagacacg ggatagaggg ttacaccgtg gtcagcggct 1026421 gcttgtattg cttcttcctc acttgctgga aacaaaaggc gcagcagaat gtgaagcccc 1026481 gagttcttac cgagaatctc aacggtgttt cccagttcag agcgaatggc ttctaacagg 1026541 acagcgtgtt tttttcggta taagcttctc attctattta tgtgtttttg ccactctccg 1026601 gtttcgatga agtctgccag tgccaattgc gagtgggcag aaacggtctg cttcattaac 1026661 tgaacattgt tttggatcgg ttccatgagt tcagggggca caatcatgaa gctgagccgc 1026721 aaggaaggca gaagtgactt tgaaaaagtg cccagatata tgactctgcc attcggatca 1026781 agaccctgta aagacggaat gggatggccg ctgtagcgaa attctccatc gtaatcatct 1026841 tctataatga atgaatttgt ttctgccgcc catgccagca gctcctgtct gcgggtaatc 1026901 gtcataatgg tcccaatcgg aaactgatgc gaaggagtcg tatacatgag ataaggattc 1026961 tgacggtaga gctcatccgg caggacgcct tctgcatcag aacaaatcgg agtgacatcc 1027021 atgtgatttg cttcaaacat ccttcttgaa cggtgaaagc ccggttcttc aaagccgatt 1027081 tttgtacctg gctttagcga aaggcaaaga ttttgcagaa gcacggtggt tcctgcgccg 1027141 atgataatct ggccgggttc acaatttact ccccgagaca gcctgacgaa tcgggcaatc 1027201 atgtgcctga gttcgtattc tccttgaggg tcgccagagg tgtgaaacga tccggaatag 1027261 cgatcaagac tttttactat gctttttctc catgcgttaa agggaaagag ggtcggatca 1027321 acgctgccct gatggaagtc aatagcaggt gcgttttttt gatgtaatcc cggctgtaca 1027381 gactgctgaa aatggtcagg agctgtcggg aatcctggtt ctacttccgc cgcgaaccag 1027441 ccgattttcg gcttgctttt gacatagccc tcagcagtta attgctcata agctcgttct 1027501 atagttgccg tgctgacatc gagcaagctg gagagcctgc gttttgacgg aagtcttgtt 1027561 ccctttgtga ttcgcgcatg tgaaatttct tgtttaaaaa aggtataaag ctgttcatac 1027621 agcggtgttt tgctcttttt atcaagaaac ggcgtaatat ccatctcatg tctcctttgt 1027681 agctggcatg gtcatttttt ctgatattgg ctatttggca aatgccattt attagctatg 1027741 atcattgtaa cgaaaggaaa ggggattgag aagatgatcc atatgaaaca attaacctcg 1027801 aaagaagaat gggctgagtc gtatccgatt atgagtgaat tgagaacaga actggatata 1027861 gagacgtatt tacaaaggct tgaagcctgt gtgcagaaag aatcgtatat gctgtttgcc 1027921 ttatatgaaa atacagcaat cagagcgctg tgcggggctc tgccgagagt ttccattcat 1027981 aaaggagagc acttgtggat tgcggatctt gttacaacgg caccttgccg atcaaaggga 1028041 tacggcaaaa tgcttttgga ttatgcctca gactgggcga gaaaagccgg actcggtttt 1028101 gtcagtcttt catctggcct tcagcgtaaa gacgcacatc gattttatac agataaaatg 1028161 ggttttacta tagaaagtta tttgttccga aaaccggtat aacgaaaaaa gacgcctgaa 1028221 aaggcgtctt ttttaaaagc caaactgtaa attcgtatct acagatacaa tggtatacac 1028281 acaaataatc acaaagagat taaggatgac gccgagcagg cctggacctg tgcgccctct 1028341 cttgatgaag agttcaacaa cgccgaacgg aacggcagcc atggcgaacg gaagcatttg 1028401 ataggaataa aacgtgacgt tgctgataat ggccaaattc agcaacagca gggacagaac 1028461 cgctgtcccg acagagatcc agccgaatac attgtgttct ttaaaaattc ttaccagttc 1028521 cataattcca cctcgccgac attcgctgat tttacagatt tatttttcag catgcgctgg 1028581 atttccttgg ttggccctgt aacgaccgaa ccgtatacat tgacaccgtt tttctctaca 1028641 taatctaatc ggttatctac attcaggtct ttccgttttg aaatgacctg agcccatttt 1028701 tcgtgtttgg acatgaattt cagggcgttg ataaactgat cgccattcga cttgcctttt 1028761 gtattaaggg cggccaagaa ctttgaatcc tttccaggat agccaagagg ttctgtggaa 1028821 gctgtcttat ttgtgttttt ctctgtttcg attgcgttcc acaaaaagct cacatcatag 1028881 cctttgaatt tgttatacac gtcttttgtc ggatatgcac ggtcatatga aaggtagacc 1028941 tctgataccg ttccttcagg caatgtgctt aacgtttttt ctgcttttgc ggtcgtttgt 1029001 tcagacttgt ttgaaggatg tgtaaagtaa tggccggttt tattcacttc taagtcatag 1029061 tagtttactg ccggcgcttt tactttgtta taaaacattt caacccgttc attccctacg 1029121 gcagccgtct tcgtgccaat ctgcttttgc agcgggaatt ccgtattcat tccaaatagc 1029181 ttcacttggc ttttcagtcc ggaagtatca acaagaacat tcggcatggt cagggctaca 1029241 gtgactgcgg cagtttccat aaactcattg ccggtgctgt gttttccacc cattccgtaa 1029301 tagaggtagc ttcccagcgt acaaagcggc aaaatcatca atgtcgaaat gacggcaagc 1029361 acagaaattc gcaaataaga cttgcgtttg ccgtaggcta aaatcgcttt ttgtttttca 1029421 ggactgatgc tgagatccca atcgttatcg tcctctagtt cgctgtcaat cagttcctga 1029481 tatacttcaa gcttctcgag ttcttcctca aatgcagtca tttcctggtc gctcatttcc 1029541 ccatttttat attgatcaaa acgcttttta aattcttcat tcatcattaa cacctctatt 1029601 ataaagtgct ttcagccgct gtctggcacg aaataaaaca cttttaaaat tcgcctctga 1029661 aatattcata atatgggatg cttctttgta gtttaactct tttaaataat atagcgttaa 1029721 ggcctcccga taattatcgg ggagctcgga catataacca gtcagcactt cctttatctc 1029781 tacctgatgg gcaggacttt gaacagcatt ttgaaagagg cttccgatta agtcatcaga 1029841 aatggttact tctttcttat gctttctgac gtaatcaatg aaggcgtttc gcgccacttg 1029901 aaaaagccag ggctttactt tgctgtgatc ataggagtga atgtgtatgt atgcccgcat 1029961 aaaggtttcc tgcagtaagt cttcagcaag atgcttgtct tttgtcatgg agagcaggaa 1030021 cctgtaaaca tcattcatgt acatttggta aatttcatcg atcgtcactg ccttttctcc 1030081 cctctatgtt atacacgcat aagaaaggtt taaagttgca cattacatgc aaacggcttt 1030141 tttataccta atcaaacacc attactatat agtacccaaa aatggccgca aaagatagtg 1030201 cggagaaagg tttaacattt tttccagagg ggaaaagata gtgaaaaagt gaaggagtgg 1030261 cacaatggaa tataccagta tagcagatac aggaatagaa gcctccagaa tcggcctcgg 1030321 cacatgggcc attggcggaa cgatgtgggg aggcactgac gaaaaaacat cgattgaaac 1030381 aatccgcgcc gctcttgatc aggggattac actgattgac accgcaccgg cttacggctt 1030441 cgggcagtcc gaggaaattg tcggaaaggc aatcaaagag tacggcaaaa gagaccaggt 1030501 gattctcgca acgaaaacgg ctctggactg gaagaacaac cagctgttcc gccatgcgaa 1030561 cagagcgaga attgtagagg aagttgagaa ttctttgaag cggcttcaaa cagactatat 1030621 tgatctttat caggtgcatt ggcccgatcc gcttgtgcca attgaagaaa cggctgaagt 1030681 catgaaggaa ttatatgatg cgggaaaaat ccgggcgatt ggcgtcagca atttttcaat 1030741 tgagcaaatg gatacatttc gcgccgtcgc acctctccat acgattcagc ctccatataa 1030801 tctgtttgaa agagagatgg aagagagtgt ccttccttat gcgaaagata acaagataac 1030861 aacattatta tacggcagtt tatgcagagg gctgttaaca ggcaaaatga ctgaagaata 1030921 tacatttgag ggcgatgatc tgcgtaatca cgatccaaaa ttccagaagc cccgctttaa 1030981 agagtatctt tctgctgtga atcaattgga taagctggcg aagacacgtt atggaaaatc 1031041 agtgattcac ttggctgtca gatggatctt agatcagccg ggagcggata tcgctctttg 1031101 gggagcaaga aagcctgggc agcttgaggc cctatctgag attacaggct ggacgctgaa 1031161 cagtgaagat cagaaagata tcaatactat attggaaaat acgatatcag accctgtcgg 1031221 accggagttt atggccccgc cgaccagaga ggaaatataa caaaagctga gggcgaatcc 1031281 tcagcttttt ggcgtttaaa cgagagaaat cttaaaaatt agtaccaggt aataaaaaat 1031341 attgttataa tagatgacag aaagaatcat tgattacgac aaaggaagtg cgatatgtat 1031401 aagttttgtg caaatgcttt aaaagttatt ctttctcttc gcggaggagt gaaggtgtat 1031461 aacaaagaaa accttccggc cgattcaggt tttgtcatcg cgtgtacaca ttccggctgg 1031521 gttgatgtga ttacactcgg agtcgggatt cttccttatc aaatacacta catggcgaaa 1031581 aaagagcttt ttcaaaataa atggatcggt tcgtttctga agaaaattca tgcctttccg 1031641 gtagatcggg aaaatcccgg gccaagcagt attaaaacgc cgattaagct gctgaaagaa 1031701 ggagagatcg tcggtatctt cccaagcgga acaagaacct ctgaggatgt gcctttgaaa 1031761 agaggtgcgg tgacgattgc gcaaatgggg aaagcgccgc ttgtccccgc tgcatatcag 1031821 ggcccttcaa gcggaaaaga attattcaaa aaaggaaaaa tgaagctgat tatcggtgag 1031881 cctcttcacc aggctgattt tgcccacctg ccttcaaagg aaagacttgc agcaatgaca 1031941 gaggctttga atcagcggat taaagaacta gagaataaac ttgatcagct ataaggcgtt 1032001 ctgagagatt gtcctgaaac tgtgaaaata agaaaagcac cctatacaag gtgcttttct 1032061 tattatgctt cctgctggtt agctgtctcc agaagttctt cttcttgaag ctttttcact 1032121 tcaatatatg cgacgtggtg gccgtcaatt tcattaatga tgaattcgca gccctcttcg 1032181 atgatggaat catctttttc aacatcgtat ttttgagtaa ggaaccagcc gccgattgta 1032241 tcgacttctt cgttctctaa atggatgcct agcaggtcgt ttacttggtc aattaacact 1032301 tttccgtcaa gaatataatg gccttcgccg attttgcgga tttcgctaat ttcatcaata 1032361 tcaaattcgt cgcggatttc accgacaatt tcctcaatga tgtcctcaac cgtcacaagc 1032421 ccggcagtac cgccgtattc atcagacaaa atggccatgt ggaccctctc tttttgcatt 1032481 ttgacaagca ggtcttggat cggcgcagat tcaatgacat gaatgatagg gttgacgaat 1032541 tgagaaatgg tggaatcaac agatacctca ccgctgatgc aggcggtcag cacttcttta 1032601 atgttaataa ccccgataat gttatcttta tcgccctctt ccacagggta gcgggtatat 1032661 ttttcaatct gaatgatgtc catcatttca gaaatcttga tatcatgcgg aaggctgaca 1032721 atttcggtcc gcggaatcat aatttctttc gcgagcctgt cgtcaaattc aaagatttta 1032781 ttcacatatt taaactctga ttggttgatt tcaccgcttt tatagctttc agacaaaatg 1032841 attcgcagct cttcttctga gtgagccagt tcgttttctg aaacggtctc caggccaaat 1032901 gctttggtca ataaccgtgc ggaattgttc aaaagccaaa tgaatgggaa cgcgatgcgg 1032961 taaaaccaaa tcagcggttt cgcaaacagc atagacactg cttccgcctt ttggatagcg 1033021 actgttttag gtgcaagttc tccgacaaca acgtgtaaga acgtgataat ggcatacgca 1033081 aaaataaacg atatgacatg tgaaagggaa cctggaacgt tcatttggac gaaaagcggg 1033141 tgaagcagcc tttcgatcgt tgattcacct aaaaccccta atccgatgga agtcaatgta 1033201 attccgagct gacacgcaga taaatattca tcaagatgcg tggtcacttt ttttacggct 1033261 attgctgctt tatttccttc cgcgatcagc tgatcgatcc gtgagcctct gattctgata 1033321 atggcaaact cagatgccac gaaaaatgcc gtcagggcga ttaaaacagc aactaaaatc 1033381 aaattcacta tgtccaatta gaaccttcac tctagcaatg agaatgaagg taacacctcc 1033441 tgttagataa aatggtttta acttaacagc agcataaatg attggaacac ggcgagcttt 1033501 tcaggcggga gtttgctttt cagcttgtca cgatcctcgg gcttcagccg ttcaaaccga 1033561 tgcaagattc cggagatgtt ttgattcata tgatcaattt ctaatgccag atttccaatt 1033621 tcatcatcaa gtttagctga agagggaaac tggttctcca gtcgatcttt aatatcggac 1033681 agggccaatc gctgcttctt gcaatctaca ataaatataa gtcgtttgag tgcattttcg 1033741 tcgtagtaac ggtaatttga acaggatctg gccggcgtaa gcagaccgag attcgtataa 1033801 taatcaactg tccgtttcgt tactccggcg agtgccgcta gttcactgat gcgataagtc 1033861 tcagccccat ctatatccct cccaaccatc acgttatagt tatgagaata gtttaatata 1033921 tgaacggtgt cttgcacaag tttattgttt tttttagacc ggaattggaa gttgtggaat 1033981 tcatcatctg attgaagtaa cataggaaga tagaattttc aaatttttat atgcggaagg 1034041 gacagatgaa attggctggg ttatcccggg aagttgaaga aaacttaaat aaaggatcat 1034101 ggattcgcaa gctgtttgat gaaggtgcaa ggctgaagaa ggagttcggg gaagaccagg 1034161 tatttgattt ttcactcggc aacccgattg ttgaaccgcc tgaagctttt aagagagcgt 1034221 taatagagga agctgaaaaa ggcagccacg gatacataca aaaccaaggg cttcttgcag 1034281 cgagagaaaa agtcgcgcaa tttctgggct cgcgttttga agctgatttc tcagcggagc 1034341 gcatcgtcat gacggtgggc gcgggaggcg ctttgaatgt tgcgttaaaa agcatcgtaa 1034401 accctgggga agaggtcatt attcttgcac cttattttgc cgaatataag ttgtatattg 1034461 agaactacgg gggaaaagcc gtcagctgcc cgttgacaag ccggtttgag atcgacattg 1034521 aagcggtaag gcaatcgatc actccacaga cgaaagggct gattctcaat acaccgcata 1034581 accccacagg cactgttctc agccagaaaa atatagacga tttaggcgct ttattaaaag 1034641 aaatagaaga gaagagcggc cagacgattt atgtgctgtt tgatgaaccg tacagtcaat 1034701 taatctatga tgaagagctg gcaaatccgt ttcaatcgta ccatcgtgtg atattggcca 1034761 gctcattcag taaagatctc ggcatagccg gagagcggct cgggtatatc ggattggaca 1034821 gccgaatgcc ggatgcggac cttttgatca acgcttttgt gtattgtaat cgaacgcttg 1034881 gatttgtgaa tgcccctgtc atgatgcagc gggctgtggc acgaatggat gatttaagag 1034941 tagacgcgag cgcttataaa gagcgccggg atttaatggt agacatttta aaagaagccg 1035001 gttttgaatt tgaaatgcca aagggaggtt tctttgtttt tccgaaatcg ccgattgaag 1035061 atgaagttgc attttgcgtg catgccgccc aaaaatacaa attattaatt gtgccgagca 1035121 gcggttttgg aatgagcggg catttccgat tatccttcag tgtgccgatc gagcagatta 1035181 aaaactcacg ggacattttc atttctttat ataaagattt tgcttaagaa ggcaaagaaa 1035241 agaaaacagt tttcaaggct gttttctttt tatatccgca aaatccttcc tcttccaatc 1035301 cagacaggcg cagaattgac aagcaggcat gcagttaagg ctttcttcat gataaaagtc 1035361 taaaaattaa aaatcatttt tggaatgagt tgtgttacaa taaaatatac aatttataat 1035421 caaactttga cttttggagg tggtatgatg gggccctctg cttaggcaac aatacaccgc 1035481 gtacctcaat gttaaggaaa aatgattata tcaggaggtg actccttatc ctttgttgag 1035541 aggatagggt taaatggacg atattgacag tctgatttta attggcgtgc tcattgcttt 1035601 aaccgcgttt ttcgttgcaa gcgagtttgc gattgttaga gtgaggagat ccagaataga 1035661 tcagcttatc acagaaggaa acaaacgggc gatactcgca aggcgtgtca ttacagattt 1035721 ggatgaatat ttatccgcat cccagctagg cattacattg acatcaatcg ggcttggcgt 1035781 actgggtgag ccggcctttg aacggctgct gcatccactg tttgaaccgc tcggcttgcc 1035841 ggactcggtt tcacatgcag tctcttttgc agtcgcgtac ggcttgatca cgttcctgca 1035901 cgttgttgta ggtgaactgg ccccgaaaac ggtcgcgatt caaaaggcag aacagctgac 1035961 tttactgata gcgggccctt tgcgtttatt ctatttgctc ctgtttccgt ttatttggat 1036021 cctcaatgga tcggcgcggc ttttatgcgg gatgttcggt ttgaagcctg cgtcagaaca 1036081 tgatggttcc cattctgagg aagaactcag gatgctgtta tctgagagtt taaaaaacgg 1036141 agagattaat ccgtctgaat ataaatatgt gaataagatt tttgaatttg ataatcggat 1036201 cgccaaagaa attatgatac cgcggaagga aatggctgct gtgtcaactg agatgacgat 1036261 ggccgagatg cttgaagtca tgctgaagga aaaatacacg cgctggccag tcacagatgg 1036321 agacaaagac agtgtgctcg gtttggtcaa tacgaagcat ttgttttctg atttgctgtt 1036381 tatgacagaa gaagaacgaa tgaagatgac gatccatccg tatgtgaggc cggtcatcga 1036441 agtgattgaa acgatcccgg ttcatgactt gctgattaaa atgcagcgcg agcgcattca 1036501 tatggctata ttgtcggatg aatacggagg aacctcggga cttgtgacga cagaggatat 1036561 tcttgaggaa attgtcggag agatccgaga tgaatttgat gaagatgaac agccgctgat 1036621 ccaaaagctt ggcgacggcc attatgtgat ggatggaaag gttcggatcg atcaggtgaa 1036681 cagccttctt ggcgcatcga ttcaagaaga cgtcgatacg atcggcgggc tgatattaaa 1036741 agaaaacatc gatattgagg ctggtgaatc cattcgcatc ggttcatata cgataaaggt 1036801 gctgaagatg gacggccgat taatcaagca aatcgatata aaagaagaag ccggcaacac 1036861 aaccgggatt acggcgcacc acaagctgcc gctgcccgag cctgtgatgc tgaacagtgc 1036921 aaccttgagc gagaaataag ctcaaggttt ttttatattg tgattgtcca gccgcaccaa 1036981 aatgcaaaaa gcgacccgca aagtgtcagg acgatgtaca agatgctttc ttttacacgt 1037041 ttggccataa ggagttgaat agtttcaacg ctgaatgtgg aaaaggtcgt aaaggcgcca 1037101 aaaaaccccg tgccaatgat aagcgagacc gaagcatttg caacgtgaag tcctgtaaat 1037161 attccgagcc cgagagctcc gagaatattg actgtcagta tgccaatggg caggctgaga 1037221 cctttggttt tggcggttat gacattgcca agccagaagc gaagcattgc gccaagtccg 1037281 ccccctatga aaatacccgc tagtgtcatt tttcctgcag cccctttctt tgctgaatgc 1037341 ctgctatgcg ccgtcccaca aaaacaccaa tcagtgcaaa tatgatccct gatatcaatg 1037401 aggctgccac atataaaaga gccaatgagg gttgtccttg caaaagcatc actgtttcct 1037461 tagaaaacgt ggacattgtt gtgaagcctc cgcaaaagcc ggtgcctaaa aaagccgaca 1037521 gcagaggccg ttttgccccg atcataaaaa atccggtcaa aatgcctaat agaaggctgc 1037581 ctgccgcatt ttccagccag gttgccgccg ggaactgacc ggtgtgtatc cataagttta 1037641 atccgtatcg gaggcaggcg ccaagcgcgc ctccgataaa aaccgcgcta tatattttca 1037701 tgtttgccat cctttatgat gaaatccggg taatctgtaa cgatgccgtc cacgcccatg 1037761 gcttgtaatt ttgccgctgt cttttgattg ttgacagtcc atgcaaatat gtttaagcca 1037821 tttttattga tggagccgat catcagacgg ttaagccgtg tgtgttttat attgacatag 1037881 tttgcaaaag agcggaaggc cttcatctga tttctggaca gcatgccaaa gttgggcctt 1037941 gtaatgaccg ctgtcggaat cgaaggataa agctcgcgga acctttggac ggagcggaac 1038001 tgaaaggatt gaacaatatt attgatagaa aaagaaaatt gccctaatag ctgtcccacc 1038061 tcttcttcaa ttccgacttg agacggatgg ccttttagtt caattaaaag gccgattttt 1038121 ttgtggtagc gcttgagcac cgcttccagg gttggaatac gctctccttg aaaagcggga 1038181 ccgtaccagc ttcctgcatc gagtttttgc aattcctcca aggtaaaatc cttaacaaag 1038241 cccgatccgt ttgttgttcg gtcaaccctg tcatcgtgta tcacaacaat ctgcctgtct 1038301 tttgtaagct ggacatccag ttcgatcata tctgcattca ttttcaccgc aaggtcaaat 1038361 gcggcaatcg tattttccgg agcgtagccg gatgctccgc gatgggcaat gatgtacaag 1038421 ctaagtcagc tcctcgtatg ggcatttctg ttattgtatc aaatccatat atgcaccgcg 1038481 atacaaactg gtgaattttt tctgccatat cggaatggtc cgggctgagg aatgcgtata 1038541 actaaaaaaa gacactcagc gtatcagaac acatttcgtc agaaaattag gtctttcgac 1038601 atgttcacaa caaaatatga tcctttataa tagcaaaaaa ggaggcgaga tcatgggaaa 1038661 agggagaatc agagtggagg aaagaattaa agccgaaacg gatgctgaaa tgcaaaaagc 1038721 aactctcctt gatcagacac aaacgaaaaa aggtaagtga ctgtccctat tgaatctggc 1038781 tgatagatga attgagaaat gaccccggcg tttcgccggg gttttgtgct gcataagaca 1038841 tttaaatgaa catccttacg aatattttag tataataaac aattgattgg gatagagggg 1038901 agacagtcat gccggattat ctgcagcagt attttacgct tgataacatc atacaaatcg 1038961 gcatcagctt ggcgattttg ctggtgtttc ttatacttag aaaattattc acaagatatt 1039021 tttttaacct gctttttaat ttgacaaacc ggccgaaaac agaaattttt aaacaggtgg 1039081 ttctggcgtt tgataagccg gccagatggt tttttgttgc ccttgggctg tttttagcga 1039141 tccggtattc accgttttta gatgagcaaa tgccggtcat cagcaaaata taccgctcac 1039201 tgattgtggc gctcttgtgt tggggtcttt gtaatttgac cgcaacatcg tcgtttatct 1039261 tccataaggt gaaccagcgc ttcgagcttg acatggatga cattctggcc ccgtttttat 1039321 ccaaattgct ccgttttgtg atcattgcgc tcagtgtcag tgtgatcgct caggaattca 1039381 attatgatgt caacggattt gtagcgggcc ttggtcttgg cggactggct tttgcgcttg 1039441 ccgcgaagga taccatcagc aacttcttcg gcggtattat cattattact gaaaagccgt 1039501 ttacaattgg tgactgggtg gagacgtcga cagtaacagg atcagtcgag gatattacct 1039561 ttaggagcac gagattcaga acagcacagg gggcgcttgt aacggtgccg aactctacgc 1039621 tgtcgatgga agcgatcacg aactggacaa gaatgaccaa acgccagatt acgttttcca 1039681 tccatgtgtc ctacgctacg ccgattgaga accttgaacg ctccattcat tctctcagaa 1039741 caatgctctt agagcatgag ggcgttgata atgaaataat catggtcaac tttgatacgt 1039801 ttgccgacag ctactacaat ttatttttta acttctatac aaaaacgacg gtttgggctg 1039861 aaaaccttaa tattagagag gatatcaact ataaaattat tgagatttta ggtgcagaag 1039921 gcgttcagtt tgcatatccc ggccaaatgg ttgttgtcaa gcaaaagcac gaaagcgacc 1039981 aattccaggt gaatctaaat aaagaggaaa aggaacgggc ttaaaagaga gacttcgtct 1040041 gacagaggcg gagtcttttt catggtaaaa taagagaaaa aggcggtgtt gagttggaaa 1040101 cattcaaaag tattctacat gaagcacaga gaattgttgt gctgaccgga gcgggaatga 1040161 gcacagaatc agggatcccc gactttcgtt cagcaggggg catttggacg gaggatgcct 1040221 caagaatgga agcgatgagc cttgattatt ttttaagtta tccgcgtctg ttttggccca 1040281 aattcaaaga attgttccag atgaaaatga gcggcagctt tgaaccgaat gaaggccatt 1040341 tgcttttagc tgagctggag aagcaaggga agcaggtcga tattttcacg caaaacattg 1040401 acggtcttca taaaaaagcg gggagcaggc atgtgtacga actgcatggt tctatccaga 1040461 cagcagcttg tccggcatgc ggcgcccgat atgatcttcc ccatttgctg gagcgggagg 1040521 tgccggagtg cacggcggcc ggaaacaatg gggacatttg cggaacggta ttaaaaaccg 1040581 atgttgttct ctttggcgat gccgtcatgc actttgacac cctttatgaa aagctggatc 1040641 aagcagatct tttattggtt atcggcacgt ctctcgaagt ggctccggct agatttgtgc 1040701 ctgaggatgc aagcctgatt cccggcatga agaaagtcat cataaacctt gaaccaacgt 1040761 attgcgacag cttgtttgac atggtcatcc atcaaaaaat cggcgagttt gcccgaagtt 1040821 tgggcatgaa aaagtgagcc gctttatgcg cctcactttt ttattcatga acaggaacca 1040881 ttgtgtcctc taacactccg aaggaatagc ctttttcttt taatttattg attagtaccg 1040941 gcagcgcatt tacagtagca ggaagatcat gcatgagaat tacatttggg cggcttgaag 1041001 agctgtgttc catattctca agctgctgta atacggcggt cacatactgt gaattccggt 1041061 atttccagtc catgctgtcg atcgtccaat cccagtacac aaacccatct ttctccagat 1041121 tgcgaatttg tgaggcggtt agtgacggct tgcttccgta tggcgttctg acaagatcgg 1041181 ttttatatcc tgtaatgtcc tgcagcgtgt cacgcgcctc ctgcatttct tttagcggag 1041241 atgtcggtgt ttgatagaac aatctgttat tgtgggtaac gccatgtaaa ccgagtgcgt 1041301 ggccttcctt ttctgctctt ttcacagcct gcttgaattc gttcatccgc ggtgacagca 1041361 taaaaaacgt cgcttttaca tcagcgcttt tcagtacgtc gagcaagcgg gttgtaacgg 1041421 ctgaagggcc gtcgtcgaag gttaagtaaa ccgttttatc tcccatgttc tgctttgtct 1041481 gcagatgttt tatcaggaga tcgggggagt cgtttttcag cttaaggctt tccttctcat 1041541 ctcgaagctg gccgtttgtt gtgacagtga cttcctttgc tttcgttgaa ctgttggaat 1041601 aacccaaaat caccataagc aaaagcagca cacataaaac tgctaaactt gcaaatttaa 1041661 aagcaagcga aactgcagaa ggagaagcct ctcctctcgt ttgtcgcata acaatctctc 1041721 cattggcata aaatctctac ataatgctgt acagcaggca gcttatgaag atgccttatg 1041781 tttacaacct atgtattacc agtcaagtat acaggaataa aactggaaag cacatagaaa 1041841 atttgtcgaa atgtcagatt ttaaggaaaa aataaactcc tttccgctat agatctcttg 1041901 atctttctgt ttttcagctt gtccaatatg gtagaattag tgataatgac agcttgaatg 1041961 acatcaggga catctcgaaa agggagggct tttatgaagg ttttagtcaa tggccggctg 1042021 attgggcgca gtgaagcatc aatcgatttg gaagatcgcg gttatcagtt tggtgacggc 1042081 atctatgaag tgatcagggt gtacaaagga gtattgttcg gcttacgtga gcatgcagag 1042141 cgttttttca gaagtgctgc tgaaatcgga atttcactgc cattcagtat agaagatctc 1042201 gagtgggacc tgcaaaagct tgtacaggaa aatgcggtca gtgagggagc ggtatacatt 1042261 cagacaacaa gaggtgtggc cccgcgaaaa caccagtatg aagccggcct cgagccgcag 1042321 actactgcct atacgtttac ggtgaaaaaa ccggagcaag agcaggcata cggagtggcg 1042381 gccattacag atgaggatct tcgctggtta agatgtgata tcaaaagtct gaatttactg 1042441 tataatgtca tgacgaagca aagggcctat gaagccggag catttgaagc cattttactt 1042501 agggacggcg ttgttacgga gggtacatcc tctaacgttt atgccgttat caacggcaca 1042561 gtgcgaacac atccggctaa tcggctcatt ctcaatggaa ttacacggat gaatatttta 1042621 ggactgattg agaagaatgg gatcaaactg gatgagactc ctgtcagtga agaagagttg 1042681 aaacaggcgg aagagatctt tatttcgtca acgacggcag aaattattcc ggtcgtgacg 1042741 ctcgatggac aatcgatcgg aagcgggaaa cccggaccgg tgaccaaaca gcttcaggct 1042801 gcttttcaag aaagcattca acaggctgct agcatttcat aaatgaacga agaaaagagc 1042861 ccgcttttta cagcggggct ctttttattt tttaacaaat ccaatcaaaa tggagatcat 1042921 tggcgatata tagaggaaga acgtaaatgg gatgtagtct atgactggaa caccaagtgc 1042981 gctcgccata aatgcgccgc tgacgcccca aggaatcaat gggttaatta atgttccgcc 1043041 gtcctctaat gatcttgtca gaaattttcg ctggatgttt cgtttgtcat ataaagattt 1043101 aaatgattgt cccggtatta atatcgataa atactgttcg cccgttgcca agttgacgcc 1043161 gatgcttgag cagacagttg ctgcaacaag acggcctttt gagcggatgc ctttcatgac 1043221 gccttccaat agtgcagaaa tcaatccgat tttctccatc aatccgccga gtgcaaaagc 1043281 aatcataatg agagagacag agcccatcat ggattgcagt ccgcctctgt taataatttt 1043341 agcggctgcc tcattgtcag tttcgaaagt tgtgccattt tgtaaagctg tcataaacgc 1043401 ctgcaggctg ctgtagggta caaaaatagc agtcaaaatt cccgaggaaa taattccggc 1043461 agtcagaacg gggattactg atacccgttt cattgccagc aaaacgacta agagcggaga 1043521 aagaagggcc cacggtgtca cgtttgcagc atcttttatt ccggttatga cctgctgaat 1043581 attatcggtt gaagcagcgt ccgctgacac tgatgaaccg agaaagtaaa acagaacgac 1043641 agtgatgagc aaagctggaa tggttgtgcc catcatatgg cgaatgtgtt caaagattgg 1043701 tatttcgcct attccggctg caaagttggt tgtgtccgac atcggcgaca ttttatcccc 1043761 aaaacaagcg ccgcatatga ctgcgcctgc tgtccattca agcggaacgc cagccgcgct 1043821 cgccacgccg atcagcgcta ctccgattgt gcttacagtt gtcagacttg agccaacaag 1043881 tgtgctgatg atcatacatg aaaacaaagc agtcaacaga aggtggcttg gttcaataaa 1043941 ggatagggca taaactgtca tagtcggtat tgcgccgctg tacatccagg cgccgattaa 1044001 gatgccgatc agcgctagaa caataatcgg ctgtacgccg tttttgatcc cgtctacaat 1044061 ccctttttca atgctcttcc agggaaatcc aaaccataaa gctgctgctg aaagcatgac 1044121 aacacttaaa aacagcggga tatgaggttc tacatgaagc aagaataagc aagaaataat 1044181 aatgcacaac atgaatataa ataaaccgac ggctaacgga aacgtcagct ttttttgaga 1044241 atccaaaata acaccccata tttatcttta atgcttttgt gcttttgggc acgaaagcat 1044301 tataacagaa aaaaacgaaa atctatgttt tttcacaatt atgaatataa aagaagtgag 1044361 cacagggcgt gctcacttta caatcaggac gggtatatcc gatttcgctg aaagcttttc 1044421 acttacactt ccgaatatta gctttttcag cctgttttgg tctctgcttc cggttacgat 1044481 catatcggca gaaatgcggt ttgcatgctc gataattgat tcagccggat cgccttctaa 1044541 tatatcgata tctccatctg cctgctgttc attcagcatc attctggctt cggcgatgac 1044601 ttcttccgta cggtcttcat agatcattgg ctcaggtgat gttacatccg atatcagcgg 1044661 atcaggaaca cttgtcatgc ctccgctgat atagcttgcc tcagctgcgg gtctgggcgg 1044721 gtcgatgacg gtctgattgt ctttcatatc atgtgaatgg gcgacggtaa tagcggcatt 1044781 tacggtttta gcaagatcaa tggctgtcag aagcgctttc ttactatttt cacttccgtc 1044841 aaacgcaaca atgatacggt cagcatggaa catccttctc accctttcaa agcgtcttac 1044901 aacactacta cccgaatttg agcacaatta accttttcct attcaagtaa tgattgacaa 1044961 taaaaggttt tgtttatatg atgataaaaa gatgaaatca gaatggaagg agggtttgct 1045021 atgccaagga atttgcgtgt ttatcaaaca gtttcatatt ggcgcggcaa accttttgtt 1045081 ctgttttcgt gaacggtttt ttaggtcgga ccgcgcgctg aaaagcgctg tgcgtaacat 1045141 atcggttaaa aaaggcatgg agctgacgct tcatgccttt tttatataca aaatctaagg 1045201 aaagacaggt gtatgggatg tgaagacaaa tacagaggcg agggcagttc gtgccaaact 1045261 ggatgaaaaa agctgcaagg aaaaaataga aggcggctga tgaggagatg gggatagatg 1045321 ttttcagttt tgaaaaagct tggctggttt tttaaggcgt actggctgcg ctatacgatt 1045381 gcgattgtcc ttttattagc agtcaatgtc attgaaatgt ttccgcctaa gctcttgggg 1045441 aacgccatag atgatatgaa agcaggggca tttactgcgg aagggctgct gttttatatc 1045501 ggtatctttt ttgtgctgac ggcggccgtg tatatcatgt cttatttttg gatgcatcag 1045561 ctgtttggcg gagcgaatct gatggagaaa attcttcgta cgaagctgat ggggcatttg 1045621 ctgactatgt cgccgccgtt ttatgaaaaa aaccgaacag gcgatttaat ggcacgaggg 1045681 acaaatgatc ttcaggccgt cagtttaacc acagggtttg gcatcttgac gttagttgat 1045741 tctacgatgt ttatgatgac gatctttttg acaatggggt ttttgatcag ctggaagctg 1045801 acctttgccg ccattatccc gcttccagtc atggcgattg caatcagtct atatggaagt 1045861 aaaattcatg agcggtttac tgaggcccaa aacgcgttcg gggcgctgaa tgacagagtg 1045921 ctggaatctg tttcaggcgt gcgggtgatt cgcgcgtatg ttcaggaaac aaacgatgtt 1045981 cgccggttta atgaaatgac cgctgatgtt tatcagaaaa atatgaaagt ggcttttatt 1046041 gattcactgt ttgagccgac ggtaaaactg cttgtcggcg caagctatct gattgggctc 1046101 ggctacggag cgtttcttgt attccggaac gagctgacgc ttggagagtt agtgtccttt 1046161 aacgtttatc tcggcatgat gatttggccg atgtttgcaa tcggtgaact cattaatgtg 1046221 atgcagcgcg gcaatgcgtc attagatcgg gtaaatgaaa ctctttctta tgaaacggat 1046281 gtgacagatc caaaacagcc cgctgatctt aaagagcctg gagatatcgt tttcagtcat 1046341 gtcagcttta catatccaag ctcaacaagt gacaatcttc aggatatttc atttacggtg 1046401 cgaaaagggc agactgtcgg gattgcaggt aaaaccggga gcggaaaaac gacaattatt 1046461 aagcagcttt tgcgccagta tcctccaggt gaagggagca ttacattttc aggtgtaccg 1046521 attcagcaaa tccctcttga ccgtctccgc ggatggatcg gatatgtgcc tcaggatcat 1046581 ttactgtttt cacggactgt aaaagaaaat attttatacg gaaaacagga tgcaactgat 1046641 aaagaggttc agcaagccat tgccgaagca cattttgaaa aagatttgca catgcttccg 1046701 tccggtctgg agacaatggt cggtgaaaaa ggcgtggcac tgtcaggcgg gcagaaacaa 1046761 agaatttcga tcgcgagagc actcatggcg aatccggaaa tcttgattct ggatgattca 1046821 ctttccgctg tagatgccaa aacagaggct gcaattatca agaacatcag agaaaaccgc 1046881 aaaggaaaaa cgacatttat tttgacacac cgattatccg cggtagagca cgctgacctg 1046941 atccttgtga tggacggcgg cgtcattgct gagagaggca cgcatcaaga actgctggcc 1047001 aataatgggt ggtaccggga acaatatgaa agacagcagc tgttcactgc ggaagaaggg 1047061 ggagcagggg catgaaaata ggaaaaacgt tatggagata cgcacttctt tatcgaaaat 1047121 tgctgatcac agccgtcctt ttgctaactg ttgccgtcgg tgcagaactg actgggccct 1047181 ttattggcaa aaaaatgata gacgaccata tcctcggcat tgagaaaaca tggtatgaag 1047241 ctgcggaaaa agataaaaat gccgttcagt ttcacggcgt ctcatatgtc agagaggacc 1047301 gattgcagga gcctgtttca aaagcaaaag aagcgcatat ttatcaagtg ggaatggcgt 1047361 tctattttgt tgatcaggct gtcagcttcg acgggaatag aacggtttct gacgggaagc 1047421 tgacgatcac aaacggagac aagagccggg catatgctgc cgaaaagctg actaagcagg 1047481 aacttttcca gttctatcag ccggaaataa agggaatggt gttactgatc tgcctgtatg 1047541 ggggcttgct tgtgttttcg gtattctttc aatacggaca gcattatctg ctgcagatga 1047601 gcgccaatcg gattattcaa aagatgaggc aggacgtgtt ttcgcacata cagaaaatgc 1047661 cgattcgcta ttttgacaac cttccggccg gaaaagtcgt tgcgcggatt accaatgata 1047721 cggaggctat tagggattta tatgtcacag tgctttcaac atttgtgaca agcggaatct 1047781 atatgttcgg gatattcacg gctttgtttc tgcttgatgt gaagcttgcg tttgtatgtc 1047841 tggcaattgt gccgattatc tggctgtggt cggtcatata ccggagatat gcgtcatatt 1047901 acaaccaaaa aatccgctcg atcaacagtg acattaacgc aaaaatgaat gagtcaattc 1047961 aaggcatgac cattattcag gctttccgcc atcaaaagga aacaatgaga gaatttgagg 1048021 aattaaatga atcacatttt tatttccaaa acaggatgct gaatttaaac tccttaatgt 1048081 cccataatct ggtcaatgtc atccgcaatc ttgcgttcgt ctgtctgatc tggcattttg 1048141 gcggtgcgag cctgaatgcg gcggggattg tttctatcgg tgtgctgtac gcgtttgtcg 1048201 attatttgaa ccggttattt cagccgatca caggcatcgt caatcagttt tcaaagctgg 1048261 agcttgcaag ggtctccgcc gggcgtgttt ttgaactgct tgaagaaaag aatacggaag 1048321 aagcgggtga accggcgaag gagcgcgcgc tggggcgggt tgaatttcgt gatgtgtcat 1048381 ttgcgtatca agaaggtgaa gaggtattaa agcatatttc ctttactgcg caaaaaggcg 1048441 aaaccgtagc gctcgtcggc cataccggat caggaaaaag ctcgattttg aatcttctgt 1048501 ttcgttttta tgatgcgcaa aaaggtgatg tcttaattga tggaaaaagc atttacaaca 1048561 tgtcaagaca ggaactcaga tcccatatgg gtattgtgct tcaggacccg tacttattct 1048621 cgggcacaat cggatctaac gtaagtctgg atgacgaaag aatgactgaa gaagaaataa 1048681 aaaatgcact gcggcaagtc ggtgctgagc ctcttcttaa gaagcttccg aagggcatta 1048741 atgagcccgt gattgaaaaa ggcagcacgc tatcctctgg agagcggcag ttaatttctt 1048801 tcgctagagc tttggcgttt gatcccgcga tcttgatttt agatgaggca acggcgcata 1048861 ttgatacaga gacagaggcc gtgatccaga aggcgcttga tgtcgtcaaa caaggacgca 1048921 ccaccttcgt catcgctcac cggctttcaa caatcagaaa tgctgatcag attttggttc 1048981 ttgataaagg agaaattgtt gagagaggga accacgagga actgatggca ttagaaggcc 1049041 aatattatca aatgtatgaa ctgcaaaagg gacagaaaca ttccattgca taacgctcaa 1049101 aaacccaaaa caatcgtgtt ttgggttttt ggtttatgta gtcaataagc cagtccgaca 1049161 cggtttccga catactcacc tgtaacgagc tcacgatata aaaagtccgc agtatcgccg 1049221 accgaaatgc ttgtgccgcc ctcaggcaaa acgttacgct ccgtacgata aacgccggtt 1049281 gctgttccgt ccgggaggta agtggggcag atgattgtcc agtctaatga tgattcttta 1049341 agcatttcgt atacttttgc atgctccttg gctgcgcggg tctgctttcg tttcgattca 1049401 tttgtttcaa accggtattt tcccggttca tatcgggaat ctaggatccc tgcggtgccg 1049461 atcgtaataa gccgtttgat atgctgttcc tccataacgg agagaatgtg tgccatagca 1049521 gttgacaagg tatcatcacc atctgtgcct agacagctga tcacgatttc agcattctcc 1049581 attatttttt tcacatcttc taagcggcgg gcgttcccca tgacagttct gtcttttgaa 1049641 aggggaagat cagcatgttg agatctgatc agagcgaaaa tatcaaatct ttcatctgct 1049701 gcagcttgtg ttaaaaaggc ttgtccgacg cggccgctgg ctcctaataa agcgattttc 1049761 attaaaaaac ctcctcgcct ttcattataa aaggatgttc tcagtttgaa cagcgcggga 1049821 aagaatacct gtacaaataa acagaacgat gggaaacata ttcatgaatc atggatacac 1049881 ttacgaattg aaccagctcc caattcacaa tggtgatgaa tgacaccccg attccctccc 1049941 tttttttcta ggatatgtgg agcaggaaaa aagggtgaca aaataaagag agcgcggaaa 1050001 ccgcgccctc tatagccata tattgaattg ttattgaact ctgccgccca tttgctgctg 1050061 agcgaaagat actaaacgtt ttgtgatttc tcctccgaca gaaccgttag cgcgagaagt 1050121 tgtgtccgct ccaaggttaa cgccgaattc agaagcgatt tcaagtttca tttgatcgat 1050181 agcctgagct gcgccaggaa ctagtaagtc atttgaagag ttttggttag ccatgtgtaa 1050241 aatctccttt ttatttagta tggttgggtt aactggagtt gcaccaatct gtgaaccctt 1050301 ctcgggtgtc actgccgcct cggcgtaacc caatgctttg ccggcttgtt actacgtatt 1050361 atgttaaaat ggccggaaaa tcatgcggag aattgtgtgg taaatcttga gaaataaaaa 1050421 aagcttagcc gtttaggcta agctagtcat aaatatgaaa aagcatcagt tcatgtatct 1050481 cgtttgtaag agcaggctcg tcagcgcggg cgggaaacaa gtctccccat tcaatctcac 1050541 cgctcttatg atagatgcct tcataatggg tccctttata ataaaatgaa attttccatc 1050601 cgggcagctt ttcttttggg aacaaaggtt tccagctgaa atgagaaatc attacggcca 1050661 cgctccttac atttggtatc aattgaccta aataaaaacg gcttatgttc attgtatcat 1050721 tgtttcagaa catcattgaa gaggcctaaa tatgcagttt gtcccagctt tggataaaga 1050781 taagcccgct ttattaaaaa agcggacagg ttacgaaggc cacaatgctt ccggagatgt 1050841 gattgccttc tcagataaat atgacgcgta ttcaaaactt cttcgttttg taagagaatc 1050901 aacatgatgc aaatttggat gagaaaaaat gcttcggccc gggcgcgaat tcgcttcaaa 1050961 catccatact ttaccgttct gatcaatgcc aaaatcgaaa ccaatctccc cgataaatcc 1051021 ctcgatatga tcatgaagga catggcttgc agtcagtgcc gctgcagaaa gctttttaat 1051081 gacctcaact ctttcagcgg gatcatcgta tacttccgca agtgtcttta cagtgccgcc 1051141 gttagaaaga tgtgttgtaa tgctgttctt tccggaaatt tttacggcga ttgctgtcac 1051201 tgtccatttt ccttttctgt ttttattggt atggacacgg aaatccgctg gtttgccttg 1051261 aaattcgatg agatcaacac cttgctgaat gagaaagtcg gacgggttgt gatgtttttg 1051321 aaattctgca aggaatgagg cggcatcgga ataatcaatt gatgtaaaag ttttggcgtc 1051381 attcgtatgc tttaccgtca ggccgccatc tgttcttgtc agctgataaa tgccggtgcc 1051441 gagtgctcca tttgccggtt tgatatagac ttttttgtat gcgccacaga gctcatctat 1051501 cagctccaca gacggtgtca gctcggatct aggcaaaaag ggtgccgttc ttggatcttt 1051561 ttcgagcaat tgatgaacgt tccatttatt gaaaaacgtt ttattaaacc atgggatctg 1051621 atattcatcg atcagcctct tttttgtatg ttgcaagaga agtgaatctt caatttttcg 1051681 gttcggcaaa cggtcataaa cgacgttcgg caatggaacg atttttttct cccagccgtt 1051741 ttccctgtaa aggaggcctt caatcgtgcc ttcctcccaa ttgatttggt gcgcgccaaa 1051801 aacgaagcag tagcccccgg cttgctcgtg taacgtgaca agtttagaaa aaaagaggga 1051861 acgatcctta aatgggcgtt caagagatac agtaaaccct gccgtaaaga tgccgactaa 1051921 cggcccgata tgcactgtat gatcatgaat cagtatatct gccctgcttc ggtggggaag 1051981 caaaagctca tgaaacagat tttcagagag aagcacggtt tgttccagat gccgtctgta 1052041 agcaacgtgg catctgacaa ccttcgttcc gaatgcggca tgcaaaagtc cgtcttgctt 1052101 cagcgaagag ggcagaaaca gggtgttttc actggttttg tctatgccga tcaaaaaccg 1052161 tttaggattc acgcggaaga actcctttct ggctttgctc agaaaacaga tattggcagc 1052221 gttttagggg acaagtgtac agctgttctt tttgctcggg agagacacgc aggattgact 1052281 tcctgcctgg tttggaattg atatctaaaa tccaaattct cccgtccttt gcaagacata 1052341 tatcaagacc gagttcaaac aacggcccat agcgctcgtc aagataatac ggaaccgatt 1052401 gggtaattga aaacacatca tctagtaaaa ccacttgctg ttttttcggt atatcttcaa 1052461 accaggagtc aaatgtcagc gcatcagatc cgcctgacaa attggccagc agcccgtgtt 1052521 tgtatccgcg tcttactgcc tttccgactg tattccattc acctgcttcg tttttttcca 1052581 taaacagacg aatatcacaa gggtattgtt ccttatcttg aatgtttaag taaggctgaa 1052641 gcaaatattg atgctgaagc acttttttgc accatgtttt aaaagaagtc tggttggaaa 1052701 acgtttttgt ctgcttatcc tttccgatgt gataagtagc agtgatgttt ttcttgccca 1052761 gcttcaaaag aatcacgcct ctgcctcccg cgccgaatgc cggtttaagg atgcaggctt 1052821 tttctttgga taaaaaggag tgaatttgtt cgtagcggct cacctttatc gtttcgggaa 1052881 tatagggatt gattacagag tgctgctgca aatcgtgaag gacggtccac ttatcgggaa 1052941 gaccccgccc gataaattcc gttttcggat attttttgag ccactcaacg attggttttg 1053001 ctttttggga atgtgaatcc ttgccgtaaa aacagcgatc ataaatataa tctggaatcg 1053061 ccatttcagt ttcgttccat gtgctgctgg ccgaatgata gaccgatgct ttgacacgca 1053121 aagtgtcagg tgaaatatca aatggtgtaa accggatgaa acgtatgccg aattcgggtg 1053181 ctcttttggc cagttctgcg gaataatccg cttcatgctg gcgggataag gacataaaac 1053241 cgagtgttat catggtgaga ctcccccttt tattcaaaag ctgccggcgg gtgtccgcag 1053301 ctttacacta aatacatgta agacgaacgc agctgacggt attctacttt acagaatacg 1053361 attctccacc ttgccctatt ccaaaagaac aagctgattt tctaagaaca ggaatttgtc 1053421 tcctcgtttg ctaagtgatt gcatgagcct ctataatacg tataggtaca taatctatat 1053481 gaaaaaagct gaagcacaga tggaggaaga tgaataggaa tgggtattgc aggaaccttt 1053541 atttttatga tcgtgatcgg cgctgccatt ggagcggtga ccaatcattt agcaattcaa 1053601 atgctgttta ggccgtataa agcgtactat ttgtttggga aacgagttcc ttttacgccc 1053661 gggctgattc caagacggcg agatgaactt gcaaaacaaa tgggactgat ggtagtcaat 1053721 catctcttaa cccctgaagg cattaaaaag cggctcgtct ctgatgcagc caaaacgcag 1053781 gctcttcgag tgggggaaca gctgattcaa aagctgtcac tttctgaagt gacagtaaaa 1053841 gaagcgcttg aaaaagccgg gatgaagcgc cccgaaaaag ctgctgatgc atggatcagc 1053901 agctggaccg atgataagct gcatgagctt ttccgccaat acggggacca atcgttaaaa 1053961 gagctggtgc ctatagaggt gcaggaaaag cttgaggaaa aaattccgat gatttcagga 1054021 tatatattgt cacggagtgt ccgttatttt gaaagtgatg aaggaaaaat ccgtcttggc 1054081 aatatgattg atgacttttt aaaagagcgc ggcatgcttg gaagcatggt gcaattgttt 1054141 cttggcaatt caagccttgc ggatcgcgtg ctgccggagc tgctgaaatt cttgcgcaat 1054201 gaggaaacaa ataaattgct ttctgatctc ttaaaaaacg aatggggcaa gctgagggag 1054261 tatacgttta atgaagcaga tgaaaaatgg aatgcaaagg cgctcatttt cagtttgaaa 1054321 cgaagagtgc tgcaagcatt ttcgactgcc cctttcttca acaatacgat tggcacgctt 1054381 accgtccgct atgaatctga gctgacccag caaatgctgc cggcactatt agacaaattg 1054441 cttgaaggta tttcgtccaa ccttgaaagt gtcttaaaac ggttgcgtct tgaggaaatc 1054501 gtcaaggagc aggtggatca gttcccggtg gagcgtcttg aagaaatggt gctgtccatt 1054561 tcaaaaaaag aatttaaaat gattacctat ttggggggcc ttctcggcgg aattataggc 1054621 gcgattcaag cattgtttgt catccttttt taagaagaaa tggtttttga ttaatgaaag 1054681 gagctccata gtctgttata gtggagtggt atgtcaaacg gcaatgatga aaggagctat 1054741 ttacaatggc tgttaatttt tatgatgtag cgtatgatct ggaaaatgca ttacgcggga 1054801 gcgaagaatt cacccgttta aaaaaccttt acgacgaagt taacgcagat gaatcagcga 1054861 agcgcatgtt cgaaaacttc cgtgatgtac agcttagact ccagcaaaaa caaatggcag 1054921 gagaagagat tacacaagaa gaagtgacgc aggctcaaaa aacagttgcg cttgtacagc 1054981 agcacgaaaa aatttctcag ctgatggaag cggagcagcg catgagcatg ctgattggtg 1055041 aattgaacaa aatcattatg aagcctttag aagagcttta cggcagtgtt gaaggctaat 1055101 aagcaaaatc ccttcttgga taagaaggga ttttttattc actcagcaaa cttggaaatc 1055161 caatgaatct tttacctctc cattgatgat gactgataat gtatgaattc ctttgtaatg 1055221 ctttctggtg gttaaatcct taaaggattg gattcttgtg tatgacttcg tttcgttttt 1055281 tcgtatattt gtttctgtta ttttaaatac tttctgatga cgctggcctc ttgcttttac 1055341 aaaatcaatt gcgtactcaa ttcttacttt ttgatccctg tctgaatgaa tatagaaaga 1055401 aaattcaagg ctttcgccaa taactatacg tttgggctgg catgttaaat catgtagttg 1055461 tatcgaatca gcattttcat aaccaaaaag cgctaaggcc tgtttatcac ccttttttaa 1055521 taaggtccga taggcgtgtt tgataatcca gtctgtatgg ggatgtgttc cgtaccattg 1055581 atctgcgact tttctcagta aatgaggatg cgtttttgat atatcattaa ggttgttggc 1055641 cacgcttttt cttacatata aagactcgtc ctgcatcagc ttctcaagga tcggcaatac 1055701 gggggaaggg tccgatttca aagccggtat cgattttccc catggcaggc ggggcctgct 1055761 gccttcgctc gcaagtcttc tcacgtgttc atttttatgc tcagaccatg caagcaattg 1055821 tgcaatcatc ttttcttgat ctaacagcaa aaaaggcctt acagcaaatt ctgaggtcga 1055881 atattgcgta aaggattcca atgcctttat tgattcttcc caatgcgcta acccgtactg 1055941 ttccacataa tctggaaata aaattccgct gagtccttta aaatgagggg ctgtatcccg 1056001 taaaattgtg agcgcttcaa cgtattgttt tggcaaagtt tcgtataaag aaactgtcac 1056061 gcggcgcatc cgctctttta aagtgagttc aggccagtcc tccagccgta atgtatccaa 1056121 gaatctgttt ttgttaaaat caggatagga tgaccttaca tgatggatca actgagatat 1056181 cagttcttca ttatatattt cttttaaatc agccatataa acaccgcttt ttcgtttatt 1056241 atttatattg tatgggaatg tacgttctgg atcaagtgta tagtcctaaa aattaacaac 1056301 tgatcctacc acggatatac aaaagttggt tacttttttt agttaaaaaa acccttgtca 1056361 tcggaaagga aaactgagat aataacattg aaagcgccta cacttaccta tttcaaatgg 1056421 atacggtcgc atatcatgcc gttatataga ggggataagc aacagagagt aagtgttcgg 1056481 agcgcatcat tggtcaaaca aggggttcct gatacatgat ttttcgtaaa tcgaaataac 1056541 gatattaggg agaatggctg cttcgatcgt atcctatcaa caagccatac ataaagtctg 1056601 ctgagccagg ctttttttgc tttaagaaaa ggttgttcta aacacagaga cagggtcata 1056661 tcctatacac aagtacagtc atcaaggagg gggacatctc tgtgtcaaaa caattgcttg 1056721 ccttaaatat agatggagcg ctgcttcggt cgaacgggaa gattcatcag gcaacgaaag 1056781 acgcgattga atatgtaaag aaaaaaggga tttacgtcac acttgtgacc aaccgtcatt 1056841 ttcgctcagc acagaaaata gcgaaatcgc taaagcttga tgccaagctg atcacccata 1056901 gcggggcata tatcgctgag aaaattgacg ccccgttttt tgaaaaaaga atttctgatg 1056961 atcatacctt taacattgtt caagtgctgg agagctatca atgcaatatt cggcttcttc 1057021 acgaaaagta ttccatcgga aacaagaaaa aggtgaattc gaatttatta gggaaagcac 1057081 tcattcatcc gtctgacccg atcttttatc cagtccagtt cgttgaatca ttaagcgatc 1057141 tcctcatgga tgagccggtg agtgcacccg tcatcgaggt gtacacggag cacgacattc 1057201 agcatgacat tacagaaacg attacaaaag ccttccctgc ggtggacgtg attcgcgtaa 1057261 acgatgagaa actgaatatc gtcccgaagg gtgtctcgaa ggaagcgggt ttggccctcg 1057321 tcgcttcaga gctgggcctg agtatggatg atgtcgtggc cattgggcat cagtatgacg 1057381 atctgccgat gatcgaactt gccggtcttg gggtagcgat ggggaatgcc gttccggaaa 1057441 ttaagagaaa ggcagattgg gttacaaggt ccaatgacga gcaaggtgtc gcttatatga 1057501 tgaaggaata tttccgaatg cagcagcgaa aaggatttct tgataagttc cacatgaaac 1057561 gtgtgtaaaa aagccgctcg cgccctgaca ggtgcggcgg cttttttgcc ggattgattt 1057621 tagcagttta tttctgtaca ctaaagaaag ttttgaatct gataaattag gtgatgaagt 1057681 tgcaaattaa aatagaaggc atacatgatg accgcctgca tcggcctctg caaaatattg 1057741 caaatttgtt ttatgaagag tgcgagcttg cgtatggcgg agaggagccc gcagattttg 1057801 tcatttcttt agcgttgtca caaacggatg agcatgtgac ggtttctgga gaagtgaagg 1057861 gtactggcat aaaggaacag catacaaaat tcttttctcc agacatgact gaaaaagaag 1057921 cttttaagca agtgaaaaac acaatttctt atgtgtatct caatcttctt caggcgcata 1057981 cgggcattac gcagaagtgg ggaatcctca caggaatccg gcccacaaag ctgcttcata 1058041 aaaaactgca aagcggaatg tccaaggagc aagcgcatgc tgagttgaaa aaagactatt 1058101 taattcatga tgaaaaaatc atgctaatgc aggaaattgt tgaccgtcag ctggcggcag 1058161 tgccggattt gtaccgagta aaggatgaag tcagcattta tatcggcatt ccgttctgcc 1058221 cgacaaaatg cgcgtattgc acattccctg cgtacgctat ccaaggacag gcgggcagag 1058281 tcggctcatt cctatgggga ctgcattacg aaatgcagaa aatcggtgaa tggctgaagg 1058341 agcatgatgt taaggttaca accatttact ttggcggcgg gacgccgaca agcattacag 1058401 cggaggagat ggatctgctg tatgaagaaa tggtccgctc cttcccggat gtgaaaaaca 1058461 ttcgtgagat tacggtggag gccggtcgtc ctgacacgat tacagaagaa aaactcgccg 1058521 ttttaaacaa atatgacatt gatcggatca gcatcaatcc gcaatcctac gaaaacgaaa 1058581 cgctaaaggc gatcgggcgg caccatacgg ttgaagagac cattgagaaa tatcatctgt 1058641 cacgccagca cggcatgaat aatattaaca tggacttgat tattggtttg cctggggaag 1058701 gcgtgaagga gttcaggcac agtctttcag aaacagaaaa actgatgccg gaatccctta 1058761 ccgttcatac tctttcattt aaacgggcgt cagaaatgac gagaaacaag cataagtaca 1058821 aagttgccgg cagggaagag gtttctcaaa tgatggaaga cgcggtagcc tggacgaaag 1058881 agcatgggta cgtgccttat tatttatacc gccagaaaaa cattcttgga aaccttgaaa 1058941 acgtcggata ctctttgccg ggacaagaaa gcatctacaa cattatgatt atggaagagg 1059001 tgcagacgat tattggcatc ggctgcggcg ctgctagtaa atttattgat cgggatacag 1059061 ggaaaattac gcattttgcg aatccgaaag atccgaaatc gtacaatgag cgcttcgagc 1059121 actacacgga cgaaaaaatc aaatatttag agcagatttt tgaaaaaacg acaaagcagc 1059181 actgattaca gtgctgcttt ttttatccct gtttttttgc gggctgaacc tcaggcttcc 1059241 atttaaatac cttgttcagc aagcggtaaa ttcgttttga ttcctttgtg acaagcggtc 1059301 ccaaaatcgc cagaatgagg acatataatg cggcaaacgg ctttaatgtg gccgacagtc 1059361 cgccggctat cccgagattc gcaacgataa tcgaaaattc tccccgcgat acgatcgtca 1059421 gcccgatatt cgatgaagcc ttatgagaaa gccctgcgcg tcgtcctgcc accattccgg 1059481 cgataaaatt tcccagaatg gtcaaaatca ctgcacccaa cgcaagccaa accgcttcac 1059541 caagcgaaaa cggatcgatg ctgaggccga agctgaaaaa gaacatcgca ccgaagaagt 1059601 cgcgaaacgg aacaacgagg tgttcaatcc tatcggaatg ctctgtttct gaaaagacca 1059661 aaccgagcag cagcgcgccg attgcttctg ctacatgaat cgtctctgaa aaaccggcga 1059721 taaaaaagag tgctgcgaaa atgacgataa taaacacttc gtttgagcga atgtccaaca 1059781 gtttgttcaa cagcggcggg agttttcttg ctgcgataaa aaacagcagc atataaccga 1059841 aggcgatcaa aatggacaag agtgcactcc ctacggatgt cgcatcacct agtataaggc 1059901 cggaaacaac ggacagatat acggcaagga aaatatcttc aaacatgatg atgccgagaa 1059961 tcaattcggt ttccgggttg gcggttcttt ttaaatcaac gagcactttt gcgacaatcg 1060021 cacttgacga gattgtgatg acgcctgcga ggatgaggac ttccagaaag gaaaatccgg 1060081 tgataaaccc gtaaagcagt ccgaggctga agttaatcaa aatataaatc gtcccgccga 1060141 ccgcgattga ttttcctgat ttgattaact tcccgacaga gaattcgagt ccgagataga 1060201 agaggaggaa cagtacgccc attcgcccga aaaactcgat gatttcactg ctttgaataa 1060261 atgttagatc aataatcccc attttcggcg cgtgcggtcc aacaagcatt cccagcacaa 1060321 tcagaaacgg aataatcgaa aatttaattt tattggcgat cacactggcg attgccacaa 1060381 gcacaagtgc agttccgact tcaaatacaa gatggtccat cggggctcac acgccctctc 1060441 cagaaagaaa atcgtgaatc agtttcttca gatgctttct ctcacctgag aggacaaggg 1060501 tgtcattttc ttcaataatc gaatccgctc cgggatttag gagcttttcc tggttgtgtt 1060561 tgataatcgc aataacagtg acatcgtaat tctggcgaac atcaagctca ccgagtgtgc 1060621 gtccgatcga tttggcgcct ttttcgacct taaaccattc aataataaga tcgctgaagg 1060681 ccatttcgat ggactccaga gcttgcggtt tatagaccat gcccccgaga atagctgcaa 1060741 tttgccttgc ttcagaatca tccaatgaaa tatttgaaag aagctcatcc gggtcccggt 1060801 cattaaaccg gtaaatttcc cttcttccgt catcatgaat gataatcgtc attttttcgt 1060861 ggcttcttgt ttcgatttca aactttttgc cgatgcccgg cagatcgttt tctttaatat 1060921 tcaatgaaaa tccctccgaa tgtagtgttg gcagtatggg gtgagttaca aataaaactt 1060981 gagcaaatta tattcggagg taattagact ggtatttgac agggacggcc aaagcctttt 1061041 ccagcctgtt tatcagcggt tcgtcaagtg gtttgacaga gagctgcctg acagactgcg 1061101 ccagcgggct gtactctttg atcagctcag ccgggtgcat gctgcccggc gatggcgttt 1061161 ttgccgattg tgtttcctgc ggatatgaag acataggcac atagctgtca gtgcttgctt 1061221 caaactggga aggcagaacc acgtccgaag ggggaaagta caccataaat aaacttaaca 1061281 gaaaactgat cagcaattta tccatgttcc tttcctccct tctcatcaag atatcccttc 1061341 tttttcacta tataaaactt tatgtttcca ttcaaacaat atgcattttt cagtatctat 1061401 tgaccttgaa aaataaaaag gtttatttgg ggatggcggg gaatgtatag gagaaagaaa 1061461 aaagtaagcg catacatgga ggtgctttta atggagtttg ttcaatatgc atgtaatggg 1061521 gccgttgcag agattatcct gaatcggcct gatgcccatc acgccctgaa tgaacagatg 1061581 ctgtctgaat tgaaggaggc agtcgaaatg gcggctgcaa gcgaggcgct catcgttctc 1061641 ctgagaggaa gcgggaaagg cttttcggcc ggcggtgata tcaggatgat gacgtcagag 1061701 catgaccctg accaatttaa acggctgatg gatacgattg aggctgtcac cctgaattta 1061761 tatcagatga agaaagtgac aattgcagcc attcatggtg ctgctgcggg actgggcctg 1061821 agtttggcgc tttgtgcgga cattgtgctc gctgaaaaaa acgccgttct cgcgatgaat 1061881 tttatcggca ttgggcttgt tccggacggc ggaggacatt atttgctgaa gaaaagaatc 1061941 ggtgaagcaa aagcgaaaaa actgatttgg agcggaaaaa aactatctgc ctcggaagct 1062001 gccgatatgg ggcttcttga tgggacattt gccggagacc ctgccgaagg cgcaagaccc 1062061 attatcgaaa ccctgttggc ctcccctctt ttggcgatga tcgaaacgaa aggtattttt 1062121 caaagcctcc aaattgaaga actgaaaaaa gtgctatccc ttgagcgcag cgcccaagag 1062181 agaatgagaa ggaccaagga tcaccaagaa ggaatccgtg cctttttaga aaaacgggag 1062241 ccgaagtttc aagcgtaaca gatcagccgg aaagctgatc atctgtgaaa caaaatcagc 1062301 tttccggctg cattgactaa acgatgagta tgactatgaa gctctttttc ttttaagagg 1062361 gcttcaccat gcgtttttgc cgcttcttca tgttctgcct cgaattgctc gtttaccagc 1062421 gtgttccccg aaggatcaaa tacggtaagg aaataatcag ccatcaggtt tctcctccat 1062481 tttaaggttt atcagtcttt cttcatttat attctaaaaa ggaaatcaaa atcctttatt 1062541 atgctttatc caaaattagt atataatggg tcagggaagg aggagattca gtgcttacaa 1062601 ttgatcacgt aacgaagaca tttggagatt ataaagccgt tgacggattg gacttagata 1062661 ttccggaaca gcaaatgttc ggtctattag gcgcaaacgg agcgggaaaa acaacaacgt 1062721 ttcgcatgat cctaggatta ttaagcatta cggagggctc aatcagctgg aagggccgtc 1062781 ctgtgaatta tcatatcagc aacaaaatcg gttatttgcc ggaagagcgg ggcctttatc 1062841 cgaaaatgaa ggtaagggat cagctcgtct atcttgccag attaaaaggg atggagaagc 1062901 gagaggctgt aaaagagctc gggacatggc ttgaacgctt caatattaca gattacgaga 1062961 ataagaaggt ggaagagctt tcgaagggga atcagcagaa aatccaattc atttcggcag 1063021 ttttgcataa gccggagctc ctgattcttg atgaaccatt cagcggcttg gaccctgtca 1063081 atgttgagct gctaaaagag gccgtgatct cgctgaaaaa cagcggtgtt tctattttat 1063141 tttcaagcca tcggatggaa catgtggagg agctttgtga gaacctttgc atattgcaga 1063201 aaggaaaacc ggttgtacaa ggcaagctga aggagatcaa gcgttctttc ggtaaaaaga 1063261 atgttaccat tcactccgat gacgatctgc gctttttgca gtcccatgaa ggcattcttc 1063321 aatggaagga aacggcagac ggcgtcaagc tgcagattgc caatgaagac atttctcaag 1063381 agatttttgc gatgctccaa ggaaaagggt ttatcagaaa gtttgagctt gaagagccgt 1063441 cactgcatga tatttttata gaaaaggtgg gggccgtcta tgaataaatt ttggatcatg 1063501 ctttctcata catacaaaaa taagattatg gcaaaatcct ttattatttc gactgtcatc 1063561 acggtgctgc ttgttttagt tgtaacgaat ctggagtcga tcatttcttt gtttcaaggt 1063621 gacgatgcga aagaaaaaat cgccgttgtt gatgaaacaa acgaattata tccggttttt 1063681 tctaagcagc tgaaagcggt ggatacagac ggcgatcttg atgtgaagct gtcgaagcaa 1063741 tcggaggatg aggtcacaaa gcaagtcaaa gatgaatcac tcgatggcat gctcatcatc 1063801 aaacgagatg aaaaagggac catttcagga acatataaag cgttaacgat ttctgatgaa 1063861 agcacgtatc aaacactgca gcaggcgctg acgcaaacca aaacagctgt cggaacagcg 1063921 gagctcggcg tgtcgcagga aacgattagc agcctttatg cgcctgttac tgtggggcag 1063981 aaggcgctga aagaaggggc aaagtctgag gaagagcttg gccagacggt agggcttgtt 1064041 tacattatgc tgttcgtcat ttatttctcg gtgattatgt atgccagcat gatagcgatg 1064101 gaggtcgcaa ccgaaaaatc ttcgcgagtt atggaaatcc tgatctcaag tatgccgccg 1064161 atccagcaaa tgtttgcaaa gctgcttggt atcgggcttg tcgggatcac acagcttgct 1064221 attattatag gagccggctc tctgtcgctt aagctgaacc aaaagagcga aacggcttca 1064281 tctgtcggcg gattccttaa tttgaccgac gtatctgcaa ccactgtcat ctatgctgtc 1064341 attttctttt tgctcggata ctttttgtac gcgacacttg ccgcgtttct cggcagtgtc 1064401 gtcagcagaa tagaggacgt gcagcaaacg atcacgccga tgacgctttt ggttgtcgcc 1064461 ggttttatga tcgcgatgtt cggtttgaat gcgcctgacg caggatttat tacggtaact 1064521 tcgtttattc cgttctttac gccaatgatt atgttcctgc gcgtcggcat gcttgatatt 1064581 ccgttctggc aggcggctgt cggaatcgga atcacactgc tcaccattgt catactggcc 1064641 gttatcggcg ccagaattta taaaggcggt gtattaattt acggcaattc aagcgcgttc 1064701 aaagcgatca aacaagcgct acgtttagcg aaaaactgat tggaaaacag cctggggatt 1064761 ctcaggctgt ttctttattg acagaacgtg cattcgcaag aattcggtgc taaaataagg 1064821 gtacttcatc ctggaaagga gcagaatgtt gactgatcta acctttattc atgcggcaga 1064881 tcttcatctt gacagcccgt tttacgggat atcgcatctg ccggagccga tttttgcccg 1064941 gattaaagaa agcacgtttg caagcgtgag acatatgata gacgccgcag tgagagagca 1065001 cgttgatttc attttgcttg cgggagatct gtttgatgaa gccaatcgaa gcttaaaggc 1065061 tcagctcttt ttgaaaaaac agtttgaaag actcagagag tgcggaattt cggtatacgt 1065121 catctttggg aatcacgatc atcttggcgg ggagtggacg ccgattgaat ggcctgagaa 1065181 tgtccatatt ttttcgtccg ctgttccaga agaaaaatcg ttttttaaag aaggcaggcg 1065241 catagcaagc atttacggct tcagctatca agccagagca ttgatggaaa accaagccgc 1065301 ccgctatcgg agatcaactg acgcaccgtt tcatatcggc atgctccacg gcacgctgtc 1065361 aggatctgaa ggacacgatc cgtattgccc gtttacacat gacgacctcg tgaaaagcgg 1065421 gatggattat tgggcgcttg gccatataca taaacgccag gttctatctg ccgagcatcc 1065481 ggcagtcatt tacccgggaa acacgcaagc acgccatata aaggagacgg gagataaagg 1065541 ctattatctc gttcatgtga caaacggaga tatatcttat gaatttcaga gagcgcatga 1065601 tgtcctgtgg gaaaaagcgg cggttgatgt gacggaggca aagaatatga cagccctctt 1065661 ccaaatggtg gaggacacgt tttcgaagct gcggaaaaag gggagccctg tttgtgtaag 1065721 gcttgtttta caagggacgg cgccggaatg gctgctggag gcgccaaaag gcaccttgga 1065781 tgagtttctt gaagctcttc aggaacaaga agcggaagag gaacgtttcg tttggcctct 1065841 tagattggac gatgagacag aaaacgaagc aaacctaaca aaccttgatc ctttttttgg 1065901 cggtttattt gaagacattg atcgcagcga tctgtcagac gtgctggaag ggcttgagcg 1065961 gcatccagtg tatagaaggc acgcggaccg gtttagccaa gaggaggtaa aggaaataaa 1066021 agagcaggca cagataatat tgaaaagaca gcttaaggtg cttgatacat gaggcggtga 1066081 cagctttgcg aattatatct ttacatatct accaatacgg aaaattttcc aatcggacct 1066141 ttgacttttc cgcctctcct gtccaagtca tctacggatt aaatgaggca ggaaaaacga 1066201 cgatgatgtc attcattgaa agcatgctgt tcggttttcc gaaaacgaaa aagtatgaac 1066261 cgaaaacagg cggtgtctac ggcggtgttc ttgaagctga acatcctgag tatggggtgc 1066321 tgaagatcga acggacgaaa gggactgccg aaaaactaag cgtgtacaca gaaaagggcg 1066381 aagtaaagca gggagatgtt ttaaagcagc tgttccaggg cacagacagg tcgttgtaca 1066441 aagccatata ttcgttcgac gtattcgggc tgcaggaaat tcacgccttt aatcgggaca 1066501 agatagggga atttttgctc ttttccagct tgtttggtgc tgaagccgta tcaaagcttg 1066561 attcaaggct gacgaaggaa agcgaaaggc tctataaacc aaatgggcga aaccctcaat 1066621 tgaatcagga gctggaaacg cttaagcagc tggcagttaa gctaaaacag gctgaagcag 1066681 aggaagcggg ctatcatcag cttctcgagg aaaaacgaac gcttgaagcc cgccttgcag 1066741 ccgcggaaac cgaattgaaa gagacggcgg gacatatccg aatgattgag ggagcgattg 1066801 agcgaaagcc gctgctaaat gaaaaagcga cactcgaaca ggtgattgca gaatttccgg 1066861 aacacgcagg acaatttcct gctgacggac tgcatcagct ggaaaaatat gaatcccatc 1066921 ttcacccgaa atcagcacag cttgaggcgc ttcgggtgaa gatggcggag ttggacaaac 1066981 agaggcaaaa gcttatcccc gataaagaac tattggcgaa agaaacgctg atacaagagc 1067041 tttcggcagc gtttcatatg taccaatcct ggggagaaca gctggcagcc attcaggcac 1067101 agctgcgcca gacgtctgcg cagacagcgg cagggctgga acagctcaat aaaacggatg 1067161 aaaatgagct cctgaatatg aacacctcat atgattatga atggcagctt cagcaagcgg 1067221 tgcagcaata tgtacaggca agagacagaa aacggcagct tgacgagacg tttgaacttg 1067281 cccggcaaga gctggaagac gcggaaaagg ccgttcgtgc cgcttcgtcc gcgattcttg 1067341 aaaacagcca aagaaaagat aaagaagcag ctcttagagc atatgatgaa acacaggggc 1067401 agcaccaaga gcaagcgaag ctcagagaac agctaacgtt ttttgaaaga cagcaggcta 1067461 aacagaaaaa gactgtcatt gcagctggta tgttgttcat cgttctcttt tctctgctgc 1067521 agcaatggat tcccgccata agtttcggcg ctgcacttat tgtgtattgg cttgtttcag 1067581 gaaagtcgtc ttctcgaaac agccgagaga caagacagcc catgacggat atttcaccag 1067641 cagaagctga aatgcttaga gaagcgttat gggaggatga ccgcaataag cagcaccttc 1067701 tcacacagcg tgcagcgctc cagcaaaaag aggcggcgta tgaaagggtc atccagcagt 1067761 ttgaacagtg ggaagccgaa atggcgccgt cctttacaca ggttgagcgt tttatgaatg 1067821 agctcggatt taaggaagat ccatcatttt tgcttgatgc atacagctta atgaaggatg 1067881 ttaaaaaaga agtgaagaaa aagcatgagc tgaccataga agcaggcagg ctgaaaaagc 1067941 accggagaac attcgaagaa cgcgtcagta tgcttcttcc cgtgaatcag agtcaggata 1068001 tctccatttc ggacgccctt cacacattgc ggaaaaacat tgaacgtgaa aaagaaattg 1068061 agaagcaaaa aaaggaaatt gaaacagata ttcattatac aaaggaacag atgcttgaac 1068121 ttgagcaaga aatacagtat ttccacgcac agattgaaca gttatttgcc gcggctgctg 1068181 caaaagacag agatgcgttt tttgccatag ccgccatcag caggcaattg aaggatacgg 1068241 agaacaagct tcatcacgta aacgcacagc ttcaaggcgg gtacccggag gaacttgaac 1068301 tggcggattc caatacgctt tctgaattga aagataagca atttgttgag aatgaaagaa 1068361 aagagcggct gactgaggag atcgagcagc tccgcagcca aatcgcactg ctctcagtca 1068421 aacaggaaca attagaggct tcgggaatgg tctcagacct caagcttcaa accgaaatgc 1068481 aaaaagaacg tgtgaaagaa acggctaaaa aatgggcctc catacaaatg gtcaaacagg 1068541 tgatcagaaa caaattggag cggcataaaa aaatcgagct tccgcgcctt ctggagacgg 1068601 caggagaatt tttccgtcct ctgactgacg gaaactacca aaccatttat ttttccgaaa 1068661 cggatgattc gatcatggtt atgcatcgcg atggcactgt ctatcatgcg gaagagctgt 1068721 cacaagggac gtgtgaacag ctgtatacag cgatccgctt tgctttggcc gttacgcgcc 1068781 agggtgagtc aaagcttccg ttccagcttg acgacagttt tgttcatttt gatcaggaaa 1068841 ggctgaaacg tgtattacat gttctgtatg atttatctga aggcggtagg cagattttgt 1068901 attttacatg ccatgagcac gtaaaagatg catttcatag cagccaaatc atccatttgg 1068961 tgtcataaaa gaggttctat agctgaaaat cggtatgtga tatactggta ttatgtaaga 1069021 tacggaggga gctttaatag aatggctaaa gggattatgc tacatgaggt tggcgaacag 1069081 gtggaccagt atctattgat taaatcctcg acgaaaggga ttgcaagcaa tggaaaaccg 1069141 tttctgacgc tgatgctgca agaccagtca ggcgatattg aagcgaagct gtgggatgcc 1069201 aagcaaagtg atgaagtgac ctatgcgccg cagacgattg tcaaggtcgt cggcgatgtt 1069261 caccattatc gcggacgcac ccagctgaag ctaagaaata tcagaccggt aagcgagcaa 1069321 gaaaacgtca atattgatga ttttttagaa accgcgccga ttccgaaaaa tgaaatgatg 1069381 gataccatca ctcaatatat atttgaaatg aaaaatccga atatccagcg aatcacaagg 1069441 tttttggtta aaaaacacga agctgagttt atggattatc cggcggctac gaaaaaccac 1069501 catgagtttg tctcaggttt ggcgtatcat gttgtctcta tgctgaacct ggcgaaagca 1069561 atagcagatt tatatccttc tcttgatcgt gatctgcttt acgccggtgt tatcctgcat 1069621 gatcttggaa aagtgaagga gctgtccggc cctgtttcca cttcatatac ggttgaaggc 1069681 aatttgctcg gccatatttc catcatggtg acagagcttt caaaagcggc tgaggagctt 1069741 caaatcgatt ctgaagaggt gttaattctt cagcatttga ttttgagtca ccacggcaaa 1069801 gcagaatggg gcagcccgaa accgcctatg gtgaaagaag cggaaattct tcactatata 1069861 gacaatctgg atgcaaaaat gaatatgatg gacagagcgc ttgagcgcgt gaagccgggc 1069921 gagtatactg aacgtgtatt tgcactggaa aaccgttcct tttataaacc gacatttcat 1069981 aaataactta aaaaggactg atgctgacat attcagctca gtcctttttg atgcgtcttt 1070041 cccgcacata actcgtctca ttcccgcata tggttaagaa taaagaatct atgcaaaggg 1070101 ggaggagccc gtgttatttt ttccgtggtg ggtgtatctt tgtattgtag gcatcatttt 1070161 cagcgcatat aaacttgtgg cggcagccaa agaggaagaa aaagtagacc aggcttttat 1070221 tgaaaaagaa ggacagattt atatggagag gatggaaaag gagcgagaac gccgcagttc 1070281 tcagcagcat gaagaagaaa atcaaaacca ttccatcgca taaaaaaagc tgtgcggctc 1070341 aatgagccgc acagcttttt ttattattta gaattgcttg aagatgaaga agtgctgttg 1070401 cttgttgaag atgtattaaa tgtgtctttc agatctttat cttttacttc gatgtcagcc 1070461 ttcttcatga ctttttgaac agcttcctga acagctgcgt tgtcatttaa tttttgttca 1070521 agcacttcag atttcagttc ttttttcata tcatcatatt tgccgcgttc ttctgtcttt 1070581 ttaatgatat ggtagccgta ttgcgttttg acaggatcac tgacttcacc tgtttttaat 1070641 ttgaatgcag ctttgctgaa tgtttcgtcc atttggcctt cttttgcgaa ccagccaaga 1070701 tccccgcctt ttgaagcaga gctgtctgtt gagtattctt tcgcaaggtc ttcaaacttc 1070761 tcgccttttt tcagcttttt ctctacttct tcagctgtct ttttatcagc aacaaggatg 1070821 tggcttgcac ggattttgcc ttttaagcct tcccagtact ctttgatatc ggcgtctgtt 1070881 actttgatgt tatctttagc cgctttttgt gtcagcaatt catattttac ttgttctttc 1070941 aggtaatctt tgccatattg cttttcgagg gcagtatatt gatcgccaag ctgcgttttg 1071001 tattctttca gcttgttgtc aatttcttta tccgaaactt tatacttctt gtccaatact 1071061 ttttcttgca ctagctgtgt cagtacgctt gcgccagctg ttttcttcat gtttgtgtaa 1071121 agctcgcctt ttgtgacatc gcctgcgtct gtttttgcga taacttcttt gtcgccgctg 1071181 ctgcaagcac tgagagcgag gatgcttgta gcagtgatag ctgctattgc gattttcttc 1071241 attgttttca aacactccta atcattccaa attaaattac ctatgcgtat cataacatat 1071301 tgtggctttc tgtaaaaaga ttttaaataa agggcattcg tctagtcaaa cttttgctga 1071361 tgacatactt atatattgat caagaaaagg aggtatgtaa catgagcgga ggatactcta 1071421 acggattcgc gttgctcgta gtactgttca ttttgcttat catcgtaggt gcagcttaca 1071481 tctactaagc agcccgagga tcgcttgcaa cataagcgat cctttatttt cactagcgcc 1071541 taatcgtttc aaacatgaat tgcataacat gtaattggta aataaagctt attacaggag 1071601 gtgctattta agatgggtga agtatttgca ggcggattcg ctttattggt tgtgttattt 1071661 attttattga ttatcatcgg cgcttcttgg ctgtactaat caacataaaa aagcatagct 1071721 gcttaatcag cagctatgct ttctttcgta tttacactgt aaaggagatc tccacaaacg 1071781 aagagatcag taaaattaat atagatacat taataaatcg gaatacctta tcttgccgct 1071841 cttcaggaat ctctctgaca aggcataatg tattggtgag cctgtttatg aaatataaaa 1071901 taaacacggc agccacgata aaatagaata aaatgatggg agattccccc tctctctgaa 1071961 ctgtcccata ttacattacc aaatatttat taaaaaagat agaatgcaaa ttgaaaaatc 1072021 gccaccagca ccagggtttg actacttttc aacaagaata tccaagccgt cagcttcctg 1072081 atcaataaaa gcggttttcg gtgcttttat cagcttgaga gccagcagga aatcaggcag 1072141 acagtagccg gcgtgaatgc ccgagatcat gcaaaaataa tgagcgtgat tcggaaatgc 1072201 cagtgctgcg taaaacaata ccggtgtaat cagcaagaac gggctgacga gtgaaatcag 1072261 cattgttgtt tttggtatac gtttccatgt gcgcatgcgc aatatgtaaa actttttttc 1072321 tatttttctt tttttgcaga tgattggcag gacatggatg actttatgta caaataaaat 1072381 aacgacgagc aaaccgccga ataaagatac atattcatcg cttaagcttg tgccaggccg 1072441 cagcagctca aaagctaaaa aggtagatat aaaaaccaaa atcataaaac atacagcagt 1072501 taatattatg cgaacggcgc cataatcctt catgagattt atggtcttcc agcaattcat 1072561 caaagtcatc cttccataca tcttgaatag aatctcaaaa taatttactc ctcccaagag 1072621 aaaaaatcaa tgctttttta agaaaaaata tcatccggca ggtatttttt tgaaacaagc 1072681 aaacaaactg cgaaatatgg ggttagaact ttcttctcag tgaattatca gctaaaataa 1072741 gattaaagat agaaagaagt ggtgtggatg gattcgatgg atcatcgcat tgagcgatta 1072801 gaatattaca tacaattatt agtgaaaaca gtagatatgg acaggtaccc cttctatgcg 1072861 cttctcattg ataaagggct gagcaaggaa gaaggggaag cggttatgag gatatgcgac 1072921 gaattgtcgg aagagctggc aacacaaaaa gcgcaaggat ttgtaacctt tgataagctc 1072981 cttgcgcttt ttgccggaca gctgaatgaa aaattagatg ttcatgaaac aatttttgcc 1073041 ctgtatgagc aggggcttta tcaagagctg atggaagtct ttatcgacat catgaagcat 1073101 tttgattaac tgtttacagg ttcgagctct tcagccggtt catccgccgc actgtccttt 1073161 gcttttttct tcaattttcc gtttacgctt tcaaagtcat tgtcaatatt ggtgagtgac 1073221 gtttcgaaaa tttccataaa atcatcgccg tagatatggc gtatcataca catcatttct 1073281 gccacttcag gaaattttcc gaataaatga tataaaggct gtgacccttt aaaaacagcg 1073341 ttgcgtgtcg gatcaaattc ctcaagcaag ctccagaata cctcggtacc ttcctcagtc 1073401 aattggacat atgtgttccg tttatcattc agccgtttgg agaaccttaa atatccccgt 1073461 tcttccagct tttttgaaaa gttgaatgcg gttgatacgt gcatgacccc gaatttcgcg 1073521 atttcagaaa tggaagctcc attcaattga tacgcaatcc ataaaatatg atgctcatta 1073581 atattcaggt catacggttt gagccattgc tgccaatcct tctcgatcga tttccaaaga 1073641 gccttgctaa gctgagccat tttctgggtg aaaaccagag cttctttcac atcatagggc 1073701 ggttccactc gattcattac gtcacctgct tctctttttc tttttctcta ttatgccaat 1073761 aaaataaaga ttaataaaga tgaaaatgta agaatttttt aataaattca caaaccattg 1073821 cgacgaaagg gtttttcggc caaaaaaaat acgggtccaa ttttggcccg catttttttc 1073881 ttttgaatag gatattagtt ttgtaaggtt ttctccagct gtctgatttt ctcttcgata 1073941 tcggcaattt ctttttgcag atcctgctgg tgaggcttga tctcttcctg ccatttttta 1074001 attgatgttt ggagctcgcc gcccacgtct ttaataacat ccgtgctttc ttttgccgct 1074061 ttgatcagct ggtcttttaa tgcaagcccg tctgacttta agcgtttgat tgtttcttca 1074121 aaagaatcat aattggtttt cattttttca cgcagctgct ttcctgagga aggtgcagta 1074181 agaagaaccg ctgctcctcc gatgatgccg cctacgaata gtcctgttaa tagagaacgt 1074241 ccgctcgcca ttacaatcac cccgtctttt tcttcaaaat aggattcatt cagcattttt 1074301 catttttgtt gaaagcctga acttctatac atagcttgct ttattttagc atatttttta 1074361 agtgaaaagg agggagaagg ttgtctgtct ttttgattgt attatcctgc atcacccttg 1074421 ccttcgcttc aggcgctgtt tactatatca aacttctcag ccaggctgct tcttatccgc 1074481 ccaagagggt tatccggcag aaagcgcttg tttgttcaac cggaaccgcc tttacactat 1074541 gtcttatctt tttcacaaaa ctcctcgctt aaaacatgct gacatgctgc gggcgctctg 1074601 ttcaaaaaaa cctctcccgg aagcggaaga ggttttgtgt gacaattatt tagcagcttc 1074661 cataaagctt gaacgcctta aaatggtttg cacaatcgga taaataatga tcattgagat 1074721 tgtattcagc acagcggccg gcagaacaac agccgcgaac aatgcggcga aaccgcccgg 1074781 taaaccgacg atcaataaag ctgacgatag aaacacaatt cctgataaga tggtcccgat 1074841 cactgtcagc acagcggctg cacctgtttt ccggctcttt ctgaacaaga gaaacaggga 1074901 gaagaacaga aacgctgata cgggtttatc aatgatgtta gggatctgtc cggctggaaa 1074961 cgcggttgta agcgcggaaa tgattccggt cacgatcccg atgacgagta cattttgcac 1075021 ccgcgggaac agcagaatgc ccatgaacat catgatcagc atcatatctg gtttcatgcc 1075081 gcctaaaaag ggcggaataa tggaatgaag cgctgcgccg attgcggcaa acagagccat 1075141 aatgactaac tcttttgttt tcataactat gctctcctct gctaagcttt ttgccctcca 1075201 ataatatgct catcatttat tgcgaaggct ttacagaatg tgttatgcaa acagtatacc 1075261 aaacggacgg tttgcatagc cagacttttt actcattttc ctgctggaat ttcttcatga 1075321 acgcagctaa tttttcacag tcttcgagag agaccgcgtt ataaatagaa gcgcggcagc 1075381 ctcccaccga acggtgtccg ccaaggccga tcatcttcgc atcttttgct ttctgaacga 1075441 atgttttcgt taattcgtca tcccgaagcg tgaatgtgac attcatgcgt gagcggctgt 1075501 cttttctggc atgtccttta tagaagccgt tgctttcatc aatacagctg tagagaacct 1075561 gcgctttttg ttcattgcgc tgttcaacag cttccacacc gccgttttcc ttgagccatt 1075621 ccagaacgag gctcagcata taaatcgcaa atgtcggcgg agtgttgtag agtgaatccg 1075681 ctttgacatg cgtggaatat ttcaagattt ttgggacgtt cgcattttca ttttgcagcc 1075741 agcttttttt catgatgact acagtcacgc cggaagggcc gaggttcttt tgggcgcctc 1075801 cgtagatcac atcaaatttg gacacatcga tttttctgct taaaatatcg ctggacatgt 1075861 cggctacgag cggaattgga gaattcggaa actcctgcca ctgagtgccg aaaattgtat 1075921 tgttggatgt gatatgtaaa tatgcgccgt cttttacatc cgtaaggtca acctctggaa 1075981 tataactgta attgtctgtt tcacttgtag cggtgataga cgtgttcccg aacagtttcg 1076041 tttctgccag tgctttttca gaccaagcgc cggtcatcac aaaatgtgcg gttttttcag 1076101 gtgttaaaaa gttcatcgga agcattgaga attgaaggct tgccccgcct tgaagaaaca 1076161 agatatcgta atcttccgga atgcccatca gttcgattaa gaggcttttc gctttttggt 1076221 gcaccgcttc atactctttg ctgcggtggg aaagctccat aacagacatg ccggattcgt 1076281 taaaatcaat aaattctttc tgtgcttttt gcagaacttc cagtggcagc gctgcaggac 1076341 ctgcgttaaa attcgttgta cgttccatta tgatctctcc ctgttttcca cgttaatgta 1076401 taaaataata caattatcct atcacaaaaa ttcagttttt tgataaaaaa ttagaattat 1076461 caaaagaaat tgacggatgt ttgcgaaatg ttcacaaaat aaaataacct catcttatga 1076521 tgaggccagg cgttttgcga tagaggaaga gatgttctgc agatcctccg gtttataatc 1076581 atcagcatgc gttttccaaa ccgctccgaa tccatctcct tttccgtagc gagggataat 1076641 atgcatatgg tagtggaaca cagattgtcc agctttttcg ccgttattgt tcagcgtatt 1076701 taagccgatc ggttcaaatt catcccggat agcgcgggcg atttttggaa cagcatggaa 1076761 atattgtttt gctaattcat ctgtaaattc atatacattc tcaatatgtg ttttcggaat 1076821 gacaagcgta tggccttttg tcacttggct gatatcaaga aaggcaagta catgttcatc 1076881 ttcatacacc ttcgctgatg gaatgtcgcc ggcaataatt ttacaaaaga tacaattctc 1076941 tgcacaatgc atgagggttc ctccttatga aattgtttag tatgtataca ttcatcgtac 1077001 cacagaaatg cagaaaatag aaaacaggat gaacggcgag cgttcaccct gaatgcagag 1077061 gaagagctta tatgaagaaa atgtgttatg cctttggtaa gcacctcatt tgtcaataaa 1077121 atgaagactt gtttaatgcc taacgattcc tgcgataaac acctcatttg acaatttgct 1077181 tcatacatga agaattcatc aattcagtga agagaaatgg tttgagcatt ggacatgttt 1077241 attttctatc caactgtttc taagacgtct ttgacaaaca cctcattttt cagttgatat 1077301 gcttttcctc tacaactttt atgatgtcca gaaccctgtc tctttatgac agcaaattca 1077361 tcatttgtta aaagggaatt gtttcaaatc aggccttgtt tttggtacta tgaagaaaaa 1077421 cactataagg ggagaaacta tgtctctgct atcggtaaaa gacttgaccg gcggatatac 1077481 aaggaatccg gttttaaaaa acgtatcatt cacccttgaa ccgaatcaaa ttgtcggctt 1077541 aatcgggctg aatggtgctg gtaaaagtac aacaatcaga cacatcatcg ggctgatgga 1077601 cccgcataaa ggttcaatcg aattaaacgg taaaacgttt gctgaggatc cggaaggcta 1077661 ccgttcacaa tttacctata tacctgaaac acctgtttta tacgaagaat tgacgctgat 1077721 ggagcatctt gaactaacag ccatggcata tggactgtca aaagaaacga tggagaaaag 1077781 gctgcctccg ctactaaagg aattccgaat ggaaaagagg ctgaagtggt tcccggccca 1077841 tttttctaaa ggaatgaagc agaaggttat gattatgtgc gcatttttgg cagagcctgc 1077901 gctctacatt attgatgagc cttttctagg gcttgatccg cttgccatta acgcgctgct 1077961 tgaacggatg aatgaagcga aaaaaggcgg ggcgagcgtg ctgatgtcaa cacacatttt 1078021 ggcaacggca gaacgctatt gcgattcgtt tattatttta cataacggcg aggtgcgggc 1078081 gcgcggcacg ctgtcagagc tcagagagca gtttggaatg aaggacgcgg cgctggacga 1078141 tttgtatctt gagcttacaa aggaagacgc tggccatgaa taatatgctt gatatttggc 1078201 agtcgcggct gcaggagcat atcaaagaaa caagaacata catgaaatat atgctcaacg 1078261 atcacctcgt cattgttttg attttttttc tagcgggcgc tgcaagctgg tacagcaaat 1078321 ggatacggga cattcccgct cactttccgt ccttttgggt gatggccgtg ctgttttcgc 1078381 tcgtattgac aagctcttat gtgcgaacgc ttttgaagga ggctgacctt gttttcttat 1078441 tgcctcttga agcaaaaatg gagccttact tgaagcaggc gtttgtctac agctatgtgt 1078501 ctcagctgtt tccgctgatt gcgctgagca tcgttgcgat gccgctttat ttcgcagtca 1078561 ctccgggagc ttcgctcgta tcgtatgccg cggtctttgt ccaactgttg ctgctgaaag 1078621 cgtggaatca ggtaatggaa tggcgaacga ctttccaaaa cgaccgcagc atgaaacgga 1078681 tggacgtcat cattcgcttt gcggcgaata cactcgttct ttattttgtt ttccaatctg 1078741 tttatatgta tgcgcttctc gtctatgtca ttatggctgt tctttatctg tatatgtctt 1078801 ccgcagcaaa acggaaaaca tttaaatggg agagccatat tgagtccgaa ttgagacgaa 1078861 agcagcgttt ctatcggatt gccaacctgt ttactgatgt gccgcatttg cgaaagcaag 1078921 ccaaacgcag agcttatctc gactttttgc tgcggcttgt gccgtttgaa cagcgcaaaa 1078981 catttgccta tatgttcacc cgcgcctttt tgcgttcgag cgattatttg ggcattcttg 1079041 tcagattaac gatcgttttc gcgctgatca ttatgtatgt ctcagccagc ccgctgattg 1079101 ccgcggtttt gactgtgttt gccattttca ttacgggcat tcagcttctg ccgctcttcg 1079161 gtcactttga ccatctggcg cttcaagagc tgtaccctgt gcaaaaagaa acaaagctga 1079221 aaagctattt ctctctatta aaaactgcac ttagtattca agcgctgctg atgtctgttg 1079281 catctgccta tgcagccggc ttgaccggtt ttctgtacgc gctgatcggt tctgccgttc 1079341 tgatttttgt tgttttgcct gcttatatga cgaccaggct gaaaaagcac ggaaagctgt 1079401 gaactgaaaa gaggtaatca aatgacagat aatcagctgc tgatgcagga agctttggaa 1079461 tggaaaatgc attttttgcg aaaggattcc atgtttgaac gcttttcgaa gcgtgtccag 1079521 acgaaggtga atgaacggat tcctgaaaaa atccatacgg tcgtcaccga gagtgtgaaa 1079581 aaaatggtag aagcgacaat ggccggctct aatatcatca cctataaaaa ggatacaagt 1079641 gcactgtcgc tcagtgaaaa aaacgaattg gcgaaaaaaa cgattgtttc ttatcaaaaa 1079701 gtggcagctg ctgagggagt cggcaccgga gcgggcggca tttttttaag cattgctgat 1079761 tttccgctgc tgctttcaat taagatgaag tgtttattta ccttgtcttc catttacggc 1079821 tttgatgtca aggatgcaca agaaaggata tttttgctgc tcgtgtttca gcttgcgttt 1079881 tcgagtgatg atggccgtaa gtcgcttttt tctgtcatcg aaaattggga gacggagaaa 1079941 aagagcatcg actggagagt gttccagcag gaatatcgcg attatatcga cgtcgtgaag 1080001 ctttttcagc ttttgccggg cgtaggagcg gcagtcggcg gaattgccaa ttataagctg 1080061 cttgctcagc ttggagaaac ggcaagacat gtttttcatc tgaggatatt aaaggaaaca 1080121 gccggagaat aaacactccg gctgtttttt tatagctgat gataggtgat cgcagcgccg 1080181 gcaaggacct tggccgctgt cagcatggct ttttcgttga tatcaaattt cggatggtgg 1080241 tgggaataga ctcgctctgg ctgttcggga gcggcgcctg taaagaaaaa agtgcccttc 1080301 acgttttgta agtaataagc aaaatcctcg ccgcccattt gtggttcacc gtcaatgacc 1080361 tgctgaacgc cctcggtatt ctttgcggtg ctcaccaagt ggttcgtttc tgcaggatgg 1080421 ttcacaaccg ctggataacc ctgttcatag gtgtactcat aggacgcgcc gtgcatgctg 1080481 catattcctt ttacaaccgc ttcaatttct ttctccagaa tgtcccggac attttcatca 1080541 aaagaacgcg ctgtgccgat gagtactgct tggtctgcga tgacattaaa cggattgtcg 1080601 gcgatgaagg agcctgtcga aatgacggcg gattgaatcg gattgacttt gcggctgaca 1080661 atgtgctgca aagaggaaac gatttgcgaa ccgattagga cggcgtcttt agtatcatgc 1080721 ggatgagcgc cgtggccgcc ctttccgaag actttaatcg taaatcggtc tgccgccgcc 1080781 attacggcgc cggggcggca gagaatagtt ccgagcggct cagttgccca aagatgagtg 1080841 ccgaatatca catccgtgtt ttcgagacat ccgtcatcaa tcattggctt tgcgcctcca 1080901 ggataatatt cttctgcatg ctggtggatc atcacaaatg ttcccttcag ttcatgtctg 1080961 ttttggtgaa ggaccttggc cactgcgaga agagctgcgg tgtggccgtc gtggccgcat 1081021 gcatgcatga caccaggcac tttggaggcg taagggacat ctttttcatc ttgaatgggg 1081081 agagcgtcaa agtcggccct caaagcgact gtagggccgg gttcgcttcc ttctatattt 1081141 gctaaaaccc ctctaccgcc aacgtttgtg cggattggga ctcctaacga ttcataatag 1081201 gaagcaataa atgcggcggt tttttcttct tgaaatgaga gctcaggata catatgaaaa 1081261 tggcgcctga tctcaaccat ttcttcaaaa cagccgtcga gctgtttgtt tatctctttc 1081321 tgcagtgtgg atatggacaa agccgcttcc cccttttcta tgcttttcca tgattgtata 1081381 gaaaaagtct gaatatttca actcatgctg ttttaaagca tcatcacagc tgcgagggtt 1081441 gtcaccaaaa ggccaatcgc gacgggaatg aagttttttc tggcaagctc aaaaggatca 1081501 actttgcaaa tggccgcggc gggaatcaaa gcccatggga ccagtgttcc tccgcccacc 1081561 cagatggcag agatttgtcc gagcgcggtc agaatagcgg gatcggcatg gagagcggac 1081621 gaaaagagct ttgcgatgga gccggcgaga gaaatgccag aaaatcctga gccgtcaagg 1081681 cctgttatgg ctccagcggc agttaatgca gtggcggcaa gctcctttga cataggcatc 1081741 atatgggata aagcaatgcc aagatcgttg acaatgccgt gggaaccttt agggagtgaa 1081801 gtgcccagta tgctttcata gcctgagtcg ccaagataaa agaaagcggc aatcgggatg 1081861 acggggccga aaaccttaaa accgaactta aatccgtcaa taaaatagcc ggtgattttt 1081921 tcaagccctt tatgcttata cacgaaaaaa tgaacggtaa agaggataca aattgcagac 1081981 ccgccaatta acgcggttgc atcatttcct tgtaggttaa acaagagcat gcaggcgata 1082041 tctgcaagaa aggcaagcgg aatcaaaaaa gccagtatgg accgcaggcg ttttggcaag 1082101 tacagcgagt tgtcttgttc gccggaaaga acgggggaaa aagaagtggg atgctcctgt 1082161 tttttgcgtt cgcgctgaat catgataaag gcagcagttg ttgttgtcac acccataatc 1082221 agcacaagcg gaatactggc cgagacgaca tcaccgactg gaatgcctgc tgcatccgca 1082281 gtcagctttg gcgccgcctg aatgacaaag tctcctgaca gggcaaaacc gtgtccgaat 1082341 aagttcatgg ccatggccgc ggcaagaggc gtcaaaccgg cacgtgcggc tgcggggagc 1082401 aggacggcgc cgatcaaagc gacacccgga gaaggccaga agaatagaga aatggcgaac 1082461 atcaggcctc caatcagcca ataggcagtc acaggccctc tcacaaggct tgcaaaggga 1082521 gaaatcatcg cttcatttat ccctgttttt gttaacaaat cactcattga aacgataaag 1082581 caaatgatga aaatcgtggg cagcagttcg ccggccgcat agataaagct gtggaataaa 1082641 ctgctgacag aagctgaaag tgaatggctg gcccatagcg atatgataaa aatgccgaat 1082701 agagaaataa atgtcgtgtc ttttctcagc agcataaata ggataattgc accgataaaa 1082761 aacacataca gaacatggac aggcaaaatc ccgacttcca tcatcgatca ctccttccgc 1082821 ttacagatta ttcataggcg ggcggaaggt gccgggacag aggggagggt tatgatggaa 1082881 gatgaacatt gatctgtttc agctgctcaa tcagatgatg ccttaatcct ctattcgctt 1082941 tttgcagatg ttttgggaag cattcaggag aaaaaatgac gcacccttca gcaagccagt 1083001 tttttctata ggcgatgatg ctttccgatg gctctatatg agttatcctc gtgctgcatc 1083061 tcgtactcat caaatccgaa ctgaaaaccg cagcacgggc agatttcatg agaatgattg 1083121 ccttcatgat catatggcgg ttcagccaat ccttaaaccc gcagactggg caagtatgct 1083181 tcattttgct ttcctcccaa taaaataagc tgccggacat gccggcagct attcgacagc 1083241 gaaatatgtg gtgacatagg aaggccggga gaagatcgac gttgtgtcaa ttccggcaga 1083301 tgtatcgcgt tttttgtggg cttctttgta agaaccggac tgctgccagt cttgaaaggc 1083361 gctttccgtt tcccacaagg tcagaatgac ataggtgtca ctgtcaagcg gacggagcac 1083421 tcgaattgct tcaaagccag gctcgttttc gacttttccc gctctgtttt taaatctgtt 1083481 ttcaaacagc ggacgccctt cctgagtaac ggcaatattg ttcaatactg caaaaccggg 1083541 atgtttgatc tctccgactt ggtcaatgac ttcataagcg tgtggtgcct ggaaaacggt 1083601 atctccgttt gtttcatgaa ttaaaatggc gttttcctgc ccctgcatca aaaggatatt 1083661 ttctgaggga tgcttctgta cgatcgtttt taaaaaatcg gctgtcccat atgtaatata 1083721 aaccttcata tcagccacct cctgcttgct agtatatcaa aacaatggta taagtttcta 1083781 ttggcgagtg cttcgaacat aattccaaac aatttttccc atactacctt tagaaaggcg 1083841 aggtgagttc atgtttaaga taaagaaaaa gaaacttttt atacctatca ttattttagt 1083901 gttaactgct tttctcgctt taataggata tatttcaatt atttttctcg gccattatgt 1083961 catagatgaa aaaaagctta ttcttcatgc ttcttcaaaa attgttgatc aaaacggaga 1084021 tgaggttgca agcctgtata cagaaaatcg cgagccggtc tcgatcaatg agattcctaa 1084081 gcaggtcaga gaagcgttta tcgctgttga ggataaaagg ttctatgagc atcacggcat 1084141 tgatgcaaaa tccgtcggaa gggcagtgta ccgcgatata ttagcaggcg gaaaggtgga 1084201 aggcggaagc acgatcaccc agcagcttgc caaaaatatt tttctgacac atgacaaaac 1084261 atttctaaga aaaacaaaag aagtgatcat tgcgattaat cttgaacggg attacagcaa 1084321 ggacaagctg cttgaaatgt atttaaacca gctttacttc ggacacgggg tttacggcat 1084381 acaagcggcg tcccactatt attttaataa agaagtaaaa gatttgactg tatctgaagg 1084441 cgctgttttg gccgctattc cgaaggcgcc ttctacgtac tctccaattt tgcaccctga 1084501 taaaaataag gagcggcgtg atacaattct aggtatgatg aatgaccaag gctatatcag 1084561 tgcgaaagag gctgtcaccg cacagggccg gacgcttgga ctgcatgtga agaaacagtc 1084621 ggaaacacct tggtttgaca gctacattga ccttgtgatc aaagaggcgg aagacaagta 1084681 ttccatttcc ggagagcagc ttcttcaagg cggatacacg atcaaggtgc cgctcgattc 1084741 gaagctgcag aagacggctt accaggtgat gaaagaggga agctattatc ccggaacaga 1084801 tcagaatgcc gagggaagcg cggtctttat taataacaag acaggcggtg tagaagcggc 1084861 catcggcgga agggattaca catccaaagg atataaccgt gtcacagctg tccgccagcc 1084921 gggttccaca tttaagccgc ttgctgtata cggaccggcg atgcaggaaa agaaatttaa 1084981 gccatattct ctattgaagg atgagttgca gtcctacgga gattatacgc cgaaaaacta 1085041 cgacagccgg tatgagggcg aagtcactat gtctgacgcc attacgtaca gcaaaaacgc 1085101 gccggctgtc tggacgctga atgagatcgg cgtcgaaaca gggaaatctt atttgaaagc 1085161 aaacggcatt gatatccctg atgaaggcct tgctcttgct ctaggcggct tggaaaaagg 1085221 cgtttcaccg ctccagcttg ccggcgcgtt tcatacattt gccgcgaatg gaacgtatac 1085281 tgaacccttc tttatctcga gcataataga tgaagacgga gaaacaatag ccgatcataa 1085341 agaagaagga aagcgggtat tcagcaagca gacgtcttgg aatatgacga gaatgctgca 1085401 gcaggtagtc aaaaagggaa cggccacgtc cggcacctat cacggcgacc tggcgggaaa 1085461 aacaggttca acatcttata caggcgtctc cggcgcgaca aaggacgcct ggtttgcagg 1085521 ctatacgccg aaaataaccg gggcagtctg gatgggctat gacaaaacgg atcaaaacca 1085581 ttatttgaaa gccgggagct catacccgac gcggctgttt aaggatattt tgacacaggc 1085641 aggagaaacc ggtcatgtgt tcacaaagcc taaaaacgtt aaagaactgg aaagcccgat 1085701 tgagctgaag ccggtcaaaa cactcacagc cgattacaca tttaaagcag cggggctctt 1085761 tactattgaa ttaaagtggg acgctcaaga ggatgatcgg gccgtataca gaatttatgt 1085821 aaacaaggac ggcgaggaga cgcttcttga ttcggttgaa gggaagggaa gctatgaaat 1085881 tccttatgcc aacttatttt cgggcgcgtc ttataaaatt gtgccttata atacacagac 1085941 aaaaagagaa ggggaaggaa ccgattacgt tcagccaaaa ttgttttcct cttaatggaa 1086001 ttcggcgatt ttttgaactt tgagctacat ttctatacca tttgcctaaa acaaggtata 1086061 gtgtaataag tcaagaaata cgaacgtatg gttgccgtat gaaaggtgga aatcagatga 1086121 gtaaacgaga aacgtttaac gagacgtttt taaaagctgc gcggggagaa aaagcggatc 1086181 acacgcctgt gtggtatatg aggcaagcag ggcgctcaca gccggaatac cgcaagctga 1086241 aggaaaagta cggattgttt gagatcacac atcagcccga actttgtgcg tatgtcacaa 1086301 gactgccggt tgagcaatac ggagtcgatg ctgcaatcct ttataaagat atcatgacgc 1086361 cgctgccgtc aatcggtgtg gatgttgaaa tcaaaaacgg gatcggtcct gtgattgatc 1086421 agccaatccg gtctctggcg gacattgaaa aactcggcca gattgatccg gaacaggacg 1086481 tgccgtacgt gcttgagacg attaaactgc ttgtcaatga gcagctgaac gtcccgctca 1086541 tcggtttctc aggtgcgcct tttacgcttg caagctatat gatcgaaggc ggcccgtcga 1086601 aaaactacaa taaaacaaaa gccttcatgt acagcatgcc agatgcatgg aatctgctga 1086661 tgtccaagct tgccgacatg atcatcgtgt acgtgaaagc gcagattgag gcaggcgcaa 1086721 aagcgattca aatctttgat tcgtgggtcg gcgcattgaa tcaggcagat tacagaacat 1086781 acatcaaacc cgtgatgaac cggatctttt cagagctcgc aaaggagaat gtgccgctga 1086841 tcatgtttgg cgttggcgca agccatcttg caggtgattg gcatgacctt cctctcgatg 1086901 ttgtcgggct tgactggaga ctcggcattg atgaagccag atcaaaagga attactaaaa 1086961 cagtgcaggg caacctggac ccgtccattt tgcttgcgcc atgggaagtc attgagcaga 1087021 aaacgaagga aatacttgat cagggtatgg agtcagacgg cttcattttc aatcttggcc 1087081 atggggtatt tcctgatgtc agtcccgagg ttttgaaaaa actgacagca tttgtccatg 1087141 aatattcaca aaacaaaaaa atgggtcaat attcctaagc atatcttttg gtatcttaat 1087201 gatatcctgt caaaatgttt gtatcagatc attaaagagg gtgtaaacag tgagtagaaa 1087261 gaaaatgggg cttctcgtga tggcgtacgg cacgccttat aaggaagaag atattgaacg 1087321 ttattataca catatcagaa gaggcagaaa gcctgaacct gaaatgcttc aagatttgaa 1087381 agacagatac gaagcgattg gcggcatttc accgcttgcc caaatcacag aacagcaggc 1087441 gcataatctg gaacagcact tgaatgaaat tcaggatgag attacgttta aagcgtatat 1087501 cggactgaag catatcgagc cgtttattga agacgccgta gcagagatgc ataaggatgg 1087561 cattacagaa gcagtcagca tcgtgctggc gccgcatttc tccacgttca gcgttcagtc 1087621 ctacaacaaa cgcgccaaag aagaggctga aaaactcggc ggcttaacga ttacgtcagt 1087681 tgaaagctgg tacgatgaac cgaagttcgt gacatattgg gttgaccgag tgaaggaaac 1087741 atatgcgtca atgcctgagg atgaaagaga aaacgcaatg ctcatcgtat ccgcacacag 1087801 cctgccggaa aaaatcaaag aatttggaga cccgtacccg gaccagcttc atgaatcggc 1087861 gaaattaatt gctgaaggcg caggcgtttc cgaatatgct gtcggctggc aaagtgaagg 1087921 gaacacgcct gatccttggc tcggacccga tgttcaggat ttaacacgtg atttattcga 1087981 acaaaaaggc tatcaagcat ttgtatatgt tcctgttggg tttgtcgcgg atcacttaga 1088041 agtgctttat gataatgatt atgaatgcaa agtggttact gacgatatcg gcgcaagcta 1088101 ttaccggccg gaaatgccaa atgccaagcc tgaatttatt gatgctttgg caacagtcgt 1088161 attaaaaaaa ttaggacgtt aaagaaggcg atgaacatga gtgacggcaa aaaacatgta 1088221 gtcatcatcg gcggcggcat taccggttta gccgccgcct tctatatgga aaaagaaatc 1088281 aaagaaaaga atctgccgct tgagctgaca cttgttgagg caagtccgag agtcggcggg 1088341 aaaatccaga ctgtcaagaa agacggctat atcatcgaaa gagggccaga ctcatttctg 1088401 gaacgaaaga aaagcgcccc gcagcttgtt aaagacttag gtcttgagca tttgcttgtc 1088461 aacaatgcga ccgggcaatc ctatgtgctt gtaaaccgca ccctgcatcc aatgccgaag 1088521 ggcgctgtaa tggggatacc gacaaaaatt gcgccgtttg tttctacggg tctgttttcc 1088581 ttgtccggga aggcgagagc tgctatggat ttcatcctgc ctgcaagcaa aacaaaggat 1088641 gatcagtcat tgggagaatt cttccgcaga cgtgtcggag atgaagtggt cgagaactta 1088701 atcgagccgc tactatcagg gatctacgca ggcgacattg acaagctcag cctgatgtcg 1088761 acatttccgc aattttatca gacggaacaa aagcatagaa gcctgattct cggcatgaaa 1088821 aaaacaaggc ctcaaggctc aggccagcag ctgacggcaa aaaaacaagg gcagttccaa 1088881 actctgtcaa ccggtttgca gacccttgta gaagagatcg aaaagcagtt aaagctgacg 1088941 aaggtgtata aaggcacaaa agtgaccaaa cttagccata gcggctcttg ctattcgctc 1089001 gaactggata acggcgtcac acttgatgct gattcagtaa ttgtgactgc tccgcataaa 1089061 gcggctgcgg gaatgctttc tgagcttcct gccatttctc atttgaaaaa tatgcactcc 1089121 acatccgtgg caaacgtcgc tttaggtttc cctgaaggct ccgtccaaat ggagcatgag 1089181 ggcacgggtt ttgtcatttc aagaaacagt gactttgcga tcacagcctg tacgtggacg 1089241 aataaaaaat ggccgcacgc agcgccggaa ggcaaaacgc tgcttcgggc atatgtcgga 1089301 aaagccggag acgaatccat tgtcgatcta tcagataatg acattatcaa cattgtgtta 1089361 gaagacttaa agaaagtcat gaacataaac ggcgagccgg aaatgacatg tgtaacccga 1089421 tggcatgaaa gcatgccgca gtaccatgtc ggccataagc agcgtatcaa ggagctgcgt 1089481 gaagcacttg catctgcgta tccgggtgtt tatatgacag gcgcttcttt cgaaggtgtc 1089541 ggcattcccg actgcattga tcaaggaaaa gctgccgtgt ctgacgcgct tacctattta 1089601 ttcagctaaa acctccgctt tatcgcggag gtttttttga tgtgcaatgg caatattgtg 1089661 taaaaaatga ttgaattgaa cagcaggtta tgatacattt gcatatgtac ttaatgacta 1089721 aaatgttcaa acggtcagtt tcgaggtgaa tacaatgtca atagatcgaa aaaagctcat 1089781 tttggaggcg gctacaaagt ctttcacgca gttcgggtat aaagcgacga caatggatct 1089841 tgtcgcaaaa cttgcgaacg tggggaaggg aaccatttat acttttttca aaaacaaaga 1089901 agagctgttt gacgagattt tcactacttt attaaaggaa atgaagcaaa aagcggatga 1089961 agcgatggag ccgagccttc cgttccatga aaatgtgcac agagcgctgt ttgccattct 1090021 ggagttcagg aaaacacatc agctgacgat taaaattttc caagagaatg ccgagattgg 1090081 tacaatggca gttcaggaag tgatccagaa aatggagcga tccatcctgt cttatatcaa 1090141 aagcaagatt gaagacggga tcaaaagcgg cgcaatcaag ccgtgcgacc ctgagctgac 1090201 agcctttgtg atgctgaagc tttatatcgc gctcattttt gactgggaaa aacaacaccc 1090261 cccgcttgat aaagagacaa ttgcgggact gcttgaattg tatgttgtca aaggattgtc 1090321 agcgaactag ataatccttt ctctttgcaa gaaaatgacc attttttatg atgagtcagt 1090381 tttagaatgg aggcatcagg atgaacacaa tacgaagtca gtggaaagac atcgtaacaa 1090441 gtaaaaaatt attgattccc atcatcgcca ttttgtttgt cccgcttatt tacagcggcg 1090501 tattcttaaa ggcttattgg gacccgtacg gcacagttga ccagctgcct gtcgttgtcg 1090561 tcaaccaaga caagggagca acgtatgaag gagaaaaact tcaaatcggt gatgatctgg 1090621 tcaaagaatt aaaggataat aacaactttg attggcattt ttccaatgat ctcgaccaat 1090681 cgttaaagga cttattgaat caaaaatatt atttagttgt cgagattcct gaggattttt 1090741 ctaagaatgc cagcactgta ttagacaaaa atccgaaaaa attggatctg aaataccata 1090801 caaatgcagg ttctaactat gtaggggcaa cgatcggcga aaaagcgatt gataaactga 1090861 aagcctctgt ttcaaaagaa gtgaccgagc aatatacgaa agttattttt gataacttta 1090921 aagatatcgc aaaaggtttg agcgacgcga gcagcggcgc gaaaaaaatt gatgacggca 1090981 caaaggatgc gaaaaacgga agcgcccagc tgaaagaaaa tctggcgaag ctgaaggaaa 1091041 gcaccgctac catcagtgac aaaacagcgc agcttgcaga tggagcggct caggtgacga 1091101 gcggcatcca atcacttgac agctcgctcg gtaaattcca ggacagcagc aaccagattt 1091161 atgataaatc tagtcagctt gcagcaggat caggcgagct gacaagcaag atgaatgaac 1091221 ttcttgccgg acttcaaaat gtgcagaagg gtacgcctaa tcttactaac gggttggatc 1091281 agctcaacag taaagtccaa gaaggttctg agaaagcggc aaaagcggaa aagatcatta 1091341 atgcgctcga tttaacgaag cttgaaactg ctgtaaacaa tctggaaaag tcagaaactg 1091401 cgatgaagga attcaaaaaa cagctgactg actttgaaaa cagtttgaaa aaccgtgatc 1091461 aggcatttaa aaatgtcatc aattcgagtg acttcttaac agcggagcaa aaaagccagc 1091521 tgattaattc tgttgagaaa aagcttccgc aagttgatgc gcctgatttt gatcaaatat 1091581 taagccagct acctacagct gatcagctgc ctgacatcgc aacgataaaa agctctcttg 1091641 aagacgtgaa agcgcaggtg gcgcaggtga aagccatgcc ggaagctaca tctaagcttt 1091701 ataacggcgc aaaaacaatc caagatgcga ttgacagatt aactgaggga gctgataaga 1091761 tatacaacgg ttctcagaag ctgacagatg gccaaactaa actgacagcg ggcatcggtg 1091821 aatataataa gcagttcgca aaagcaaaag cgggctcaga gcaattggtg acaggaagca 1091881 gccaagtatc cggcggattg tttaagctgt tagacgggtc taaacaggtc caaagcggat 1091941 catcaaaact tgcagacgga tctgcatcac ttgatacagg tttaggcaag ctattggacg 1092001 gcacaggaga gctgtctagt aagctgaagg atgcggctga ccaaacagga gatatcgatg 1092061 ctgatgatca aacatacggc atgtttgcgg atccggttaa aaccaaagat gatgccattc 1092121 attccgttcc taactatgga acagggctga caccttatat cctgtcaatg ggcttgtatg 1092181 tcggcggcat catgctgacg gttgtcttcc cgctgaagga agcgtcagga cgtccgagaa 1092241 acggttttga gtggttcttc agcaaattca atgtcatgat gcttgtagga atcattcaat 1092301 cattgattgt ggcgacggtt cttctattgg gaattggtct tgaggtagag agcacgtgga 1092361 gattttacgt gtttacgatc attacgagtc tcgctttcct ggcgataatt caatttttgg 1092421 ctacaacgat gggcaacccg gggcgattta tcgcagtcat tattttagtg ctgcagctgg 1092481 gagcgagcgg aggaaccttc ccgctggaat tgcttccgaa tttctatcag gtcatccacg 1092541 gcgcattgcc gatgacctac agcattaacg gattcagagc agtcatttca aacggtgact 1092601 ttggctacat gtggcagatg gccggcgtct taatcggcat tgccctcgtc atgattgcac 1092661 taagcattac ttactttaca atgttaagcc ggaaggaaga aacatcagaa gaacagccgg 1092721 cttcataaag aaaaagaact tgtttccttg gaaacaagtt ctttttttgt tacatccccc 1092781 atttaataag caatcctgta taggttaatc cgccgccaaa cccgaaaagc aaaacgattt 1092841 gatctttttt cagcttcccg gctttcactg cgagatcgag cgccaaaaca attgaaaccg 1092901 aagacgtgtt tccgtagtgc tcaacactag tgagcgtttt ttcaatcggg aacggtgttt 1092961 tttcacaaat tgactcgatc atgcgcaagt tggcgctgtg aggaacaaac caatcgagat 1093021 catcggagct gagtcctgct ttatgtaaaa gccgttcaaa ttcgccaggg acggttcttg 1093081 cggcccattt atatacctcg cgtccgtttt gcaccatttt tccggaaccg acaagctgca 1093141 caccgtttat ttcatttcgc agtccggcac gatacaaaat atcgccgccg ttcccgcttg 1093201 ttccttgtac agacgcaaga aatcccggcg tctcttcatc tcgttctact aacagcgcac 1093261 ccgcggcatc gccgaacagt acgcatgtcg ttcgatcggt ataatcggtt acctttgata 1093321 acgtctctcc ggcgatgacg agaatttttt gatgaaggcc agatgtgatc aatccatttg 1093381 ccaaatggag gccgtatgtc agcccggcgc atgtcgcatt aatatccagc gcgccggtgc 1093441 tttcccagcc gaaatattcc tgtacgcggc atgccgtact cggaaaggcg taatcggatg 1093501 tggttgtggc aacgaggatc atatcgacat catcaagcgt tcctttataa cggctcttga 1093561 gattcttcac cgcttctatg cataaatcag aggtaaattg atgttcatcc gcaatccggc 1093621 gttctctcat tcctgtgcgc tgaacgatcc attcatcaga ggtatcaacg atcttttcta 1093681 aatctgcatt ggttaaacgt ctgctcggcg cataggtgcc gatagctgta atttttgctt 1093741 ttgacatatg aatcactcct tatggtcaga ttataacact agatattagt atctggtact 1093801 aaaaagaagg tttttttaca aaaaaagaga agtgtagata ggaatctatg aaaaagaaaa 1093861 aggaggctga aaaatggtca gtcaagaagc agtagtcttt ttggcattat ccggggctat 1093921 tgcgtttctg ttgccaatcg ggctgattgt atggtttaag cgaaagtatg gtgcctcgct 1093981 taaagtgttt tttattggcg ctctcacgtt ttttgtcttc gctcagctgc tggaaggcgg 1094041 cgttcatgtt tatgtactgc aagtgaatga aatgacgaaa gaagcgatgc agcatccatt 1094101 atggtatggc atttacggct gcttgatggc cggcattttt gaggagtgcg gaaggtattt 1094161 gatgatgcga ttttttatga agcgccatca tacttgggca gatggtctgg ctttcggggc 1094221 aggccatggc gggcttgaag ccatcctgat tacaggcttg tcctctatct cacttattgt 1094281 atacgcattt gcaatcaata gcgggacgtt tgaacagctt ttggtcaatg gcgacgtcaa 1094341 acaggcgctt ttgccgatac aggagcagct gctgcatact ccttcgtatg aatggatgct 1094401 gggcggaata gaaagaatca gtgccattgc cgtccagatt ggtctgtctc tgcttgtttt 1094461 gtacgcggtt aaaaaccgcc ggccgctgtt tttgctgtat tctattcttt tacatgcact 1094521 gtttaatgtc ccggcggttt tatatcaaag aggaatcata gagcatgctg cagctgttga 1094581 aatcattgtt gctcttatag cggctttatc agtttattgg attgtaaaag caaaaagggt 1094641 gtttcaataa aaggtccaag cagcagcaat gcccgcttgg aaaaatgtga atggaaatat 1094701 tcattaagca tgggtcatca gaatatttct gattcagtct ttagcaatga cagcaagaat 1094761 gtctgtgttt tttacaagag aaacaatggt gtttcttttt cttcttctcg caagggtcat 1094821 ggcattcttt ctttttcttg caatggtcgt ggaaatcttt atcgaaccac tcgtcaaaga 1094881 accaaaaatc atcgaaccaa tcgtgacaac gacatttctg ttcatgtgaa tgacgacagc 1094941 acatagaaat ccctcctctt cccatgctct ctacagcata tgagagattg ataggaaaag 1095001 attggacggg tccctcggga aaagagtata ttttaagtag aaaataaaag gaggaatgcc 1095061 ctatgacgtc cgtacgtaaa acgatggagc tcattaaaga acttgtatcg atcccaagcc 1095121 cgacaggaaa tacatatgag gtgatcaatt atattgaaag ccttttaaaa gaatggaagg 1095181 tagaaacggt tcggaaccac aagggcggct taattgcaac gcttccagga cgcgacacat 1095241 cccggcatcg catgctgaca gcgcacgttg acaccctcgg cgctatggtg aaggaaatta 1095301 aagcggacgg ccggctgaaa atcgacttaa tcggcgggtt ccgctacaac tcgattgagg 1095361 gggagtattg ccaaattgaa accgcctcgg gaaaaatgta cacaggcaca atcttaatgc 1095421 atcaaacgtc tgtgcacgta tacaaagacg cgggaaaggc tgagcggaat caagagaata 1095481 tggagatccg cctagatgaa cctgttcact gccggaaaga tacggaggag cttggcattg 1095541 gcgtcggaga ctttgtgtcg tttgatccac gtgtcgagat cacatcaagc ggatttatta 1095601 aatcgcgcca tttggatgac aaagcaagcg tcgccttatt gctccgctta attcatgaaa 1095661 ttcaaacaga agacattgag ctgccgtata caacccattt tcttatttcc aataatgaag 1095721 aaatcggtta cggcgggaat tcgaatattc ctcctgaaac agttgaatat ttggcggttg 1095781 atatgggcgc tatcggtgac gggcaggcga cggatgaata ttcagtatca atctgtgtga 1095841 aggatgcgag cgggccgtat cattatcagc tcagaaagca tttagttcaa ttagccgaga 1095901 agcatcatat tgactataag cttgatatat atccgtacta cgggtctgat gcgtcagcag 1095961 cgatcaaatc cgggcatgat attgtgcatg gcctcatagg gccgggaatt gacgcttccc 1096021 atgcatttga acgcacccat aaatcatctc ttcgccatac cgctaagctt ctgtattact 1096081 atgtacagtc accaatggta taagggggag gaccaatgaa gatttataag ctgaaaagca 1096141 cattcggttg ggaaggtgat gacgggttgg gagaacagct gattcagcag atccttgccg 1096201 gagaaaaaag cgccacgtgc gcgccgaaat cattgtattc aaaagatgaa ttgagggacg 1096261 tttatcaaac agcgggtcag cttgttaccg tttatgataa acatgacaat ccaagatgca 1096321 atataaaagt aacagatgtc tttgaaacca cctttggtgc gcctgatatg aggttagtca 1096381 aaggagaggg caatggagac cgaattgagg agtttcaaga ggatcatcgg atggcatggg 1096441 cggaactgat caaaagcggt gaactggagc tgaatgagga tactgttttg attacagagt 1096501 tgtttgtgct tgttaaagat taaaaaagcc tgcggggcaa gaaccccgca ggcttttcat 1096561 taaccagaaa tggttgcgtt ttgttctgtt ttcgattggg acataacagt ttctgctttc 1096621 gcaggattaa acatgccttc ccatttagac atcacaacgg cagcaagcgc gttaccagtc 1096681 aggttgacaa ctgtacgtgc catatccatg atgcggtcta cgccggcaat aaaggcaagt 1096741 ccttcagccg gaacgccgat ggtgccaagc gttgcaagca agacaacaaa agaagtacca 1096801 ggtacggcag ccatcccttt ggatgtcacc attaagacga gcacaagcgt aatttggtgc 1096861 caaatcgtca aatcaatgcc atatacctgt gctaaaaaga gtgcggcaat agattgatag 1096921 agaacggaac cgtctaagtt aaacgtgtaa ccgatcggaa tgacaaatga aacaatgcct 1096981 tttggacatc cgattttctc cattttttcc atgatacgcg gaagaaccgt ttcagagctg 1097041 gacgtactga acgccagtaa gatttcgtcc ttcatgtaag caaggaactt gaagatgctg 1097101 atgccggcaa tttttgcgac aatcccgaaa ataacaatta agaagaaagc aagcgcgaca 1097161 taaaccaatc cgacgagctt tccgagagag ataagagaac cgagtccgaa tttagacaca 1097221 gtcactccga taagagcgaa aacgccgaat ggcgccactt tcatcacaag gtttacaacg 1097281 tggaacatgg catgggatac accttcaaaa aaggctaata caggcttgcc tctttcaccg 1097341 atcgcggaaa tacccaatgc aaatagtact gtaaagcaga tgatggctag aagatcccct 1097401 tcgaccaatg actggaagaa gtttgtcggc acaatatgga ggaacgtttc cgccactgat 1097461 ttattacttt gttctttttc agtttcaaca tattgactga tgtccgattt ttgagcttcg 1097521 tgtatattaa ctcctgtacc cggatggaag atgtttgcaa gggctagtcc gagaataatg 1097581 gcaaaagtcg tgatgatctc gaagtacaga atcgttctga agcctaattt accgacttgc 1097641 tttccatttc ctgcaccggc tacaccgatg attaagctgg agacaacaat aggaatcact 1097701 atcattttga ttaagcgtaa aaagagatcc ccgattggct gcaggtaagt aggcaatgct 1097761 gggttgccat accaaatgac gccaacaatg acacctagaa taagtccaac gaatatttgt 1097821 gtggctaatc caaacttaat tcttttcata gattacctcc caaaaaacaa agtatcaaca 1097881 tatatcatga atagacatat atttaatctc actattagat caaattataa tagataagaa 1097941 atcaattcgt ctatagtaaa ttatatttcg aaaataaaga atattcaatg acattatgat 1098001 aatcaccaga attatctaaa aacaggtgag ctttgaccta acctgactat tatttcaaaa 1098061 ttaagagata tgtgaaaaaa taagaaaatc ccacgcgtaa ggcgcgggat tttcgctcat 1098121 tacaaatcgt ttacttttat acagtcattg cagatattac cataacactc atgctgctct 1098181 tctatctttt ttccgcattc cgcacacttt ttcgaaggca ggtttctaaa aaattctgtg 1098241 attttcccca gcataaccaa tccctctttc ccctttgtag tgatttcatt gtaatataac 1098301 agattacaaa aatcaataac tgttttgata caatgtttaa aacatgcttt tttcaagaaa 1098361 aatgggtata ttgaaggagg accaattttt ttgaaaagat aggaggacat tatgaaagtt 1098421 acagttatcg gatgctatgg cggttttccg gccgcaaatg aagcgacgtc aggctatttg 1098481 tttcagtcag gtgattactc tctgcttgtt gattgcggca gtgccgtatt gtctaagctg 1098541 ttcggatatg tgccggcgga aaagctggat gcggtcgttc tgtctcatta tcaccatgac 1098601 catatcgctg atatcggacc gctgcaattt gccaagcaag tcggttcgtt tctcggcaaa 1098661 ggagagcata cgcttccgat ttacggacat gatgctgata tagaacagtt tcaaaagctt 1098721 acatataaaa cacatacaaa agggatcgcc tatcagccgg atcagccgct gactgccggt 1098781 ccgtttacga tcaccttttt aaaaacgatt cacccggtga cgtgctatgc catgcggatt 1098841 actgacggca gccacactgt cgtttatact gctgattcca gctatcagga ttcatttata 1098901 ccgttttcga aagatgctga tttattgatc tcagaatgca atttttatgc cgatcaagac 1098961 ggaacaagtg caggccatat gaacagcctg gaagctgggc gcattgcaaa agaagccgga 1099021 gcgggagaac tgctgctgac acatttgccg cattttggcg tgcatgacaa ccttcgcaaa 1099081 gaagcgaaaa ccgtttttaa cggagaagtg aatattgcga aatcaggttt tgtgtgggaa 1099141 ggataaagga ggagcaccat gttatttata gacaatcaaa atatcaatga tccgcggatc 1099201 aatcttgcta tcgaggagta ctgtgtaaag catttagacc ctgaacagca atatttgctc 1099261 ttttatgtga atcaaccgtc tattatcatt gggaaaaacc aaaatacaat agaagaaatc 1099321 aatacaaaat atgttgagga aaacgggatt atcgtcgtcc gccgtttatc aggcgggggc 1099381 gctgtgtacc atgatctggg gaacttgaac ttcagcttta ttaccaagga tgacggggac 1099441 agctttcata actttaaaaa attcactgag ccagtgattc aggcgttaca tcagcttggg 1099501 gttgaagccg aattaagcgg ccggaacgac attgtagtag atggccggaa aatatccgga 1099561 aacgctcagt ttgcaacgaa aggccgtatt ttcagccacg gcaccctcat gtttgattca 1099621 gccattgatc atgttgtatc agcattaaag gtgaaaaagg ataaaattga atcaaaaggc 1099681 atcaaatcga tcagaagccg agtggcaaac atcagtgagt ttctcgatga taaaatgacc 1099741 accgaagaat tccgcagcca tttgcttcgc catattttta acacaaacga cgttggaaac 1099801 gtgccggagt ataagctgac ggaaaaagat tgggagacca ttcatcaaat ttcgaaagag 1099861 cgctatcaga attgggattg gaactacggc cgctcaccaa aatttaacct taatcattcg 1099921 aagcgttatc cggttggatc gatcgatttg cacctggaag tcaagaaagg caaaatcgag 1099981 gactgcaaaa tcttcggaga tttcttcggt gtcggtgatg tatctgaaat tgaaaacctg 1100041 ctggtcggaa aacaatacga acgcagcgtc atcgctgatg tgctcgaagg tgtgaatctc 1100101 aagcattact ttgggaacat tacgaaagag gatttccttg atctgattta ctaaggcaaa 1100161 acacatcgtt tgaaagagcg gttgtgtttt tgaaataatg gaggcaggag ggattcacat 1100221 gaaagtgttt ttaatcggag cgaacggaca aatcgggcaa agactcgtct ctttattcca 1100281 agataatcct gatcattcca tcagagcgat ggtcagaaaa gaagaacaga aagcgtctct 1100341 tgaagctgcc ggtgcagaag ctgtgcttgc gaatctggag ggcagcccgg aagaaatcgc 1100401 cgctgcggca aaaggttgtg acgcgatcat tttcacagcc ggttccggcg gcagcacagg 1100461 ctatgataaa acgctgctgg tggatcttga tggagcggca aaagccattg aagctgcggc 1100521 cattgccgga atcaaacggt ttattatggt cagcgccctg caagcccata accgtgaaaa 1100581 ttggaatgag gcactcaagc cttattatgt ggccaagcat tatgctgata aaattctgga 1100641 agcgagcggt ttaacctata cgattatccg tccgggaggc cttcgcaatg agcctggaac 1100701 gggaactgtt tcagcagcga aggatctgga gcggggattt atttcccgtg atgacgttgc 1100761 aaaaacggtc attgcctctt tagatgagaa gaatacggaa aatcgggcct ttgatctgac 1100821 agaaggagat acgccgattg ccgaagcatt gaagaaacta tgacagtact gacactcagg 1100881 gctttttgct cttgagtgtt tttttctgtt tctctataat ggagaagaaa gcttggcttc 1100941 aataatgaat gactattcat tcacttaagg ggtgggagaa tgaatcttgt ttcaaaattg 1101001 gaagaaacag catctgagaa gcccgacagc atcgcatgca ggtttaaaga tcacatgatg 1101061 acgtatcaag agctgaatga atatattcag cgatttgcgg acggccttca ggaagccggt 1101121 atggagaaag gggaccattt agctttgctg cttggcaatt cgcctgattt tatcatcgcg 1101181 ttttttggcg ctttaaaagc tgggatcgta gttgttccca tcaatccgtt gtacacgccg 1101241 acagaaattg gttatatgct gacaaatggc gatgtaaagg caatcgtggg cgttagccag 1101301 cttttgccgc tttatgagag catgcatgaa tcgctgccaa aggttgagct cgtcatttta 1101361 tgccagacgg gggaggccga gccggaagct gcggacccag aggtcaggat gaaaatgaca 1101421 acgtttgcaa aaatattgcg gccgacatct gccgctaaac aaaaccaaga acctgtacct 1101481 gatgataccg cggttatttt atatacgtca ggaacgactg gaaaaccgaa aggcgcgatg 1101541 ctgacacatc agaatttgta cagcaatgcc aacgatgtcg caggctattt gggaatggat 1101601 gagagggaca atgtggtctg cgctcttccc atgtttcacg tgttttgttt aaccgtctgt 1101661 atgaatgcac cgctgatgag cggcgcaact gtattgattg agcctcaatt cagtccggca 1101721 tctgttttta agcttgttaa gcagcagcag gcgaccattt ttgccggtgt gcctacaatg 1101781 tataactact tgtttcagca tgaaaacgga aagaaagatg atttttcttc gatccggctg 1101841 tgcatttcgg gaggcgcgtc catgccagtc gcgttgctga cggcgtttga agaaaaattc 1101901 ggtgttacca ttttggaagg ctacgggctc tcggaagcat cacccgtcac gtgctttaac 1101961 ccgtttgaca ggggcagaaa gccgggctcc atcgggacaa gtatcttaca tgtcgaaaac 1102021 aaggtcgtag atccgctcgg acgcgagctg cccgctcacc aggtcggcga attgatcgtg 1102081 aaaggcccca atgtgatgaa gggctattat aaaatgccga tggaaacaga gcatgcatta 1102141 aaagacgggt ggctttatac gggggacttg gcaagacggg atgaggacgg ctatttttac 1102201 attgttgacc ggaaaaaaga catgatcatt gtaggaggat acaatgtgta tccgcgggag 1102261 gtggaggagg tgctgtacag ccatccggac gtcaaggagg cggttgtcat cggcgtgccg 1102321 gacccccaaa gcggggaagc ggtaaaggga tatgtggtgc cgaaacgctc tggggtaaca 1102381 gaggaggaca tcatgcagca ctgcgaaaag catctggcaa aatacaagcg gcctgccgcc 1102441 attacgtttc ttgacgatat tccgaaaaat gcgacgggga aaatgctcag acgggcactg 1102501 agagatattt tgccccaata aaatgaaaaa gcgaagcggt tagcttcgct ttttcatttt 1102561 caatcctttg cttctttttt aataatattt agcagcgcct ttgtatcatt tttgcttaat 1102621 ttgtagtatg tgccatcctt caaaaaaacg gcttgctggc tgccgtcaat ccatagtctg 1102681 aatgagtcat accggtcttt atgaaacttg attgtccctt cgtaatcagg ggctgatgtt 1102741 ttttctgtct tcacctgttt tccctgattc ataatatcca gcatatcttt gacgtgctgt 1102801 cttttttcaa tctcgatatc ttcctggccg cttgaagaca gtgtgatcaa atccgcgtct 1102861 accgattgat acacatcgcc tgatcggctg taaagataaa aaaatgcgat aaacacaaga 1102921 ccgattacca cgatggctgc cactattttt ttcatttgca tcactccaaa cattgttagt 1102981 tttcccagcg atcggggttt ccatgcttaa aagggtggaa aagtgcggaa cacagcttgg 1103041 ttctaagaat ttgaatttat gattacaata gaagtaacgg gttgatgtga ggagtgaggc 1103101 gttatgcgca agtggattgc ggcagcagga cttgcttacg tgctgtacgg gctgtttttt 1103161 tattggtatt ttttcctgtc gggtgattcc gcaataccgg aagccgtgaa agggacgcag 1103221 gctgatccgg cttctttcat gaagccgtct gagttggcag tggccgagca gtattcgaat 1103281 gtcaagaatt ttttattttt tatcggggta ccacttgatt ggtttctgtt ttttgttctg 1103341 cttgtcagcg gtgtttcaaa gaaaatcaag aaatggatcg aagcggccgt gccttttcgg 1103401 tttttgcaga ccgttggttt tgtgtttgtg ctttcgctga ttacaacatt ggtgacgctg 1103461 cctttagatt ggataggcta tcaagtatcg cttgactata acatttccac acagacaacg 1103521 gccagctggg ctaaggatca ggttatcagc ttttggatca gctttccaat ctttacgctt 1103581 tgcgttctcg ttttttattg gctgatcaaa aggcatgaaa aaaaatggtg gttatacgcc 1103641 tggctgttaa cagtgccgtt ttcgctgttt ctgtttttta ttcagccggt cattatcgat 1103701 cctttataca atgattttta tccgctgaaa aacaaagagc ttgaaagcaa aattttagag 1103761 ctggcagatg aagccaatat tccggctgac catgtatatg aagtgaacat gtcagaaaaa 1103821 acaaatgcgc tgaatgccta tgttacagga attggggcca ataaacggat tgtattgtgg 1103881 gatacgacgc tgaacaaact tgacgattca gaaattctgt ttattatggg ccacgaaatg 1103941 ggccattatg tcatgaagca cgtttacatc ggtctggctg gctatttgct cgtgtcgctc 1104001 gccggatttt atgtcattga taagctttac aagcggacgg ttcgcctaac ccgcagcatg 1104061 tttcatttag aagggcggca tgatcttgcg gcacttccgc tgttattgct tttgttttct 1104121 gttttgagct ttgcggttac gcctttttct aatgctgtct cgcgttatca ggagaataag 1104181 gctgaccagt atgggatcga gttgacagag aacagagaag ccgctgttaa aacgtttcag 1104241 gatttggccg tgacggggct gagccaggtt gatcctccgg tgcttgtgaa gattttcaga 1104301 ggcagccatc cgtcgatcat ggaacggatt caacatgcgg agaaagaaga gaatgcgccg 1104361 gaacatcagg atgctgacaa ataaaaagaa gcaggtatgg aggaacctgc ttctttttac 1104421 tattattgtg cagctgcttg tacgttgatt aacccttttc catagtagaa agagtttcca 1104481 agatatgttg cagtgctttc taaacgatca cggacttgcg cgtttgtcca agtcgggtgc 1104541 ttagaaagaa ttaacgctgc tgctccggca acgtgaggag tcgccatgga cgttccgtta 1104601 taagcgccgt aagtgcctcc aggaagtgtg ctttggatgg acacgccagg agccatcaca 1104661 tcaagctcag aacctgcgct ggagaatgaa gctctttggt tgctgctgtt taccgcacct 1104721 actgcaatag tagaaggata ttttgcaggg tagccgactg tgcttgtgct tccggatgaa 1104781 ccttcgtttc cggctgcggc agcaacgacg ataccgctgg aaacggcttt gtcaacgact 1104841 gttttcagcg ctgtagaacc agtaggtccg ccaaggctca tgttgataac atccatattg 1104901 ttggaaatgg cccactcaat gccgttaata atccagctat attggccgct tcctgttgaa 1104961 tcaagcactt ttactgcata taatgatgcg cttggcgcta cgcccagaac accgattgag 1105021 ttattaagag cggcaatcgt accggctaca tgcgtaccgt gagaactgcc gtcctggtat 1105081 gggtttgttt cagaaggtac gaagcttgct ccgcctctga cgtttaagtc aggatgagaa 1105141 gagtcaattc cgctgtcgat aacagctact tttacgttag agcctgtgta gccttgagag 1105201 tgaagagccg gcgctttaat ttgagaaatg ccataaggaa cagattgcgc atattcatgt 1105261 gcaatatgat cttcttccac atatgcaacg ctcggatctt ttttcaattc ttttacagct 1105321 ttttcatcca atgttgctgc ggccgcgtta acatacttaa attgcttttg aacctttccg 1105381 cctttttcag aaataacatc ctttttcttg gcggaactca tggcactcat tgtctgttta 1105441 aatccgacaa tgtatttctt ttctgtactg ctttttccgg cagcctgcgc agacatgttg 1105501 ctgaacgcca tcgtaaagat taacgttaac gcaaacaaca agctgatcca caattttttg 1105561 cttctcactc tttaccctct ccttttaaaa aaattcagag tagacttact taaaagacta 1105621 ttctgtgaat ttattgtaat agatggaata atattttagt agacccattt ttttgagatg 1105681 attttatctc tatttaggta tatcatctct cgctatttcc gtagagactc gaaataacta 1105741 ttttcataca gaaaagaacg aaaatagaca tgagtaaatg ttcattatgc tgaaatgtca 1105801 tgctttttta ggttaaatgc tcctgagtcc cggcaaattc ctgtcgaaaa aattcgttca 1105861 aatgacctgc gtgtgcttcc gtgagaacaa tggatattat cgtgatattt tttcaaagca 1105921 tgatgataaa agtattctga aaaataaact ttacagaaaa gggatagaat gaaaaaatta 1105981 ttgagaggga ggaagaaata agatgaacat tcgccaagca aagacatcag atgcggccgc 1106041 cattgcgccg ctgtttaacc aatatcggga attttataga caggcatccg atttgcaagg 1106101 ggcagaggct tttttgaaag ctcgtttgga aaatcacgag tctgttattt tgatagcaga 1106161 agaaaatgga gaattcatag gctttaccca gctctatcca acgttttctt ctgtgtcaat 1106221 gaaaaggata tacatattaa atgacttatt tgtcgttcct catgcgcgta caaagggagc 1106281 cggcggccgg ctgctttctg ccgcaaagga ttatgcaggg caaaacgggg caaaatgttt 1106341 aacacttcag actgagcacc acaaccggaa ggcaagaagc ttgtatgagc aaaacggcta 1106401 tgaagaggat accggatttg tccattattg tctcaatgtg ccggcgaagt gaaaatggcg 1106461 gcttgatgat ttggtttttt gaacgttctt cggttacgat ataaatgaaa aggagtgtgc 1106521 cgaatgtcaa cgttatttca agccttgcag gcagaaaaaa atgccgatga tgtttcagtc 1106581 catgtgaaaa ccatatcaac agaggatttg ccgaaggatg gtgtcctgat taaagttgct 1106641 tattccggca ttaattacaa agatggtctg gccggaaaag caggaggcaa tatcgtcaga 1106701 gagtatccgc ttattttagg cattgatgct gcgggtacgg tcgtctcttc caatgatccg 1106761 cgttttgcgg agggggatga ggtgatcgcg acaagctatg agctcggtgt ctcacgtgat 1106821 ggcggattaa gtgaatacgc ttcggtgcct ggtgactggc tggtgccttt gccacagaat 1106881 ctttcgttaa aagaagcgat ggtgtacgga acggcgggat ttactgcggc gttatcagtg 1106941 catcggcttg aacagaacgg tctgtctccg gaaaaaggca gcgtgctagt cacaggagca 1107001 accggcggtg tcggcggaat tgcggtatcg atgctgaaca agcggggtta tgatgtggtg 1107061 gcaagtaccg gaaaccggga ggcggctgat tatttgaaac agcttggtgc aagcgaagta 1107121 atcagcaggg aagatgtcta tgacggaacg cttaaggcgc tgtccaagca gcaatggcag 1107181 ggagcggttg atccagtcgg cggaaaacag cttgcctcgc ttttaagcaa aattcaatac 1107241 ggcggatctg tcgcagtgag cggcttaacc ggcggaggag aagttccggc aaccgtgtat 1107301 ccttttattc ttcgcggagt aagcctgctc ggaatcgatt cagtatattg tccgatggac 1107361 gtcagagccg ctgtttggga gcgcatgtct tctgatctca agcctgatca gctgctgacc 1107421 atcgtggaca gggaagtatc attggaagaa acgccgggtg cgttaaaaga tattttgcaa 1107481 aatcgcattc aaggaagagt gattgtgaag ctttaacagg atcagcttgc agagaatgtt 1107541 atttttctgc aagctttttt gtggacagga tgatcagctg ctgaactgct gtgtcgcgaa 1107601 acaagatttt cctgtaagcc gaactttctc ttctcatttt aaaaataatt ggtgataatg 1107661 attctcattc cgtgttatac tactcttgga catcttaacc atagaaacta ccaacaggag 1107721 agactggaac atatgaaaaa aacactgatt attcttacag ttttacttct ttctgtctta 1107781 acggctgctt gctcgtcttc aagcggcaat caaaacagta aagaacataa agtggcggta 1107841 acacatgatt tagggaagac aaatgtgcct gagcatccga agcgggttgt tgttcttgag 1107901 ctaggtttta ttgatacact gcttgatctc ggcattacgc ctgtcggggt tgccgatgac 1107961 aacaaagcga agcagctgat caacaaggat gtgctgaaga aaattgacgg ctacacatct 1108021 gtcggcactc gctcacagcc aagcatggaa aaaatcgctt cattaaaacc cgatttaatt 1108081 attgctgaca cgacccggca taagaaggtg tacgatcagc tgaaaaaaat agcgccgacg 1108141 attgcactta ataatttaaa tgctgattat caggatacaa ttgacgcttc gcttacgatt 1108201 gcaaaagcag tcggcaagga gaaggaaatg gagaaaaagc tgacggcgca tgaagaaaag 1108261 cttagcgaga caaagcagaa aatcagcgcg aacagccagt ccgtgctttt gatcggaaat 1108321 acaaatgata ccattatggc cagggatgaa aacttcttta catcgagact tttaacacag 1108381 gtcggctacc gatatgcaat cagtacgtca ggcaatagcg attcaagcaa tggcggcgac 1108441 tctgtgaata tgaaaatgac actggagcag ctgctgaaaa cagatccgga tgtgatcatc 1108501 ctgatgacag gaaaaacaga tgacctcgac gccgacggta aacgcccgat cgaaaagaat 1108561 gtcctttgga aaaaactgaa ggcagtgaaa aacgggcatg tataccacgt ggatcgtgcg 1108621 gtgtggtctc tgcgccgcag tgtagacggg gcgaatgcca ttttggacga gcttcaaaaa 1108681 gagatgccgg ctgctaagaa ataaaagaaa agacaggcaa acgcctgtct ttttcttatt 1108741 tgataaagcc ggataagtgg ctgttgatat tatagtcttt tatccgccat ttttcttctg 1108801 caaattcaat gttgctgagg caggcgttga cgagacgggt gctttgaagc tccgggtcac 1108861 cgccggatat ttctgtcagc agggcgtgaa ttgccgcacc gtgcgccacg atcagcacct 1108921 tcttgtttgg atacgcctga ttcacttttg ccaaaccgcc catcagcctg tcagtgagtt 1108981 cttctaaggt ttccatattc ggatagatgt tatctggata gcgctttgtc cgttcctcca 1109041 gcggcatgcc ctccgcgtcg ccgtaatcgc gttccttaaa atcatccatc tcgactatcg 1109101 gaagatgcag atattcatta ataatttccg cggttctttt cgctcttttc agcgggctcg 1109161 tcacaataat atcccaagaa aagtccttta catattctcc ggtttctctt gcttggcgtt 1109221 cacctgttgc gtttagcggg atatcggttt tgccttggca tttttgctgc aggttccaat 1109281 cggtttctcc atgtcttact aaacaaacgg ctgtcataaa atccccttcc tgactttatt 1109341 catatcgcta ttatactaaa tcgaaagcgt gtgtcctatg aaaaagccta tgcaagaact 1109401 tcaaataata aagccagtcc gattccgccg ccgcttccga tggctgcaac agcatattga 1109461 cagtctggcc gtcttttcgc ttcataaaac aatctggtta ccagagctgc acctgatgca 1109521 ccgtacggat ggccaagagc taaggcgccg ccgcgcacat tgatttttga aaagggaatg 1109581 ccgagttctt gcgagcagac acaaattttg acggcaaagg cttcattgat ttcaaataaa 1109641 tcgatatcat caggtgttac atcgtgtgta tgtaagagct gacgaatcgc gacaaccggt 1109701 gccgcgggcg gaaagttggg gtgaatgccg ctgacagcgc tgccgataaa ccgaagcaca 1109761 ggcttaagtc ccagggctgc tgctttttct tcttccatta ccaaaagagc ggctgctccg 1109821 tctgctatgc cactgctgtt ggctgctgtg actgttccgg agctggtgtc gaaaaccggc 1109881 tttgcacggg gaataatcgc ttctattggc cgcgttttca aaaatgcttc gtccgtctcc 1109941 aattccccga gagcaacaac ttcttcacgg taaaatcctt catcatgcgc gttcctgctg 1110001 cgttgatggc tgagaagcgc gtactcatcc tgcatgcttc tgctgatgga atagcgtgca 1110061 gccgtatatt ctgccgcaat gcccatgtct ggatcgccga tcgcatctgg agaaaagcga 1110121 gcccgttctg aaaaagggga ttggctgctg ctttctgagc cgcccgcgat atacatcgtg 1110181 ccggctcccg cttgaataag gctgcaggca tagcgcacag cttcaaggcc ggagccgcac 1110241 tgtctgtcaa ttgtcattcc gggaaccgat aaaggcagtc cggcttgaag ggctgacagt 1110301 ctggccaggt tgccgcctct gccagtagcg tttccgagaa tgacctcgtc aacttgatcc 1110361 tctagctttc ggctgagaca gcggatgatg ggagccgcca aatcctccgg caggaagggc 1110421 ttcagcagtc cgttttgatt tccaaagatc gttcgttttg catcaacaat aaccgcattc 1110481 atttatactg tacactctct tccagccatt ttttcactct ggaacgggca atttttccgc 1110541 tgctcgtttc cggcaagctg tctgcaaaca cccatttttt cggaatttta taggaggcta 1110601 atttctgttt acaccaggct ttcagtgttc tggcattagc gtttccaaga atgacagcta 1110661 cagcgatttc tccccaatac tcgtcgggaa tgccaacgac agccgcgctt tcaacctctg 1110721 ggcaggcgag aagcacacgt tcaatttctt ctgggaaaat atttaatcct ccgtacacga 1110781 tcatcccgtt ttctcttcct gatatgtata gaaagccctc ttcatcaacg tagcccatat 1110841 catctactgt catccattca tctggtgtgc tgccgttcac atagccggaa aacctcatcg 1110901 ggcttttgac aaatattttt ccgatttctc ctggctggca gcgttctcct ccagcgttgc 1110961 ggatttcgat ccggacatta tgaaaagggc ggcccgctga atgcggcttc cgtttgctgt 1111021 cttccggtga agaaaacgtc acaaaactaa gctctgatgt gccgtaaaaa tcgtacagct 1111081 tgagatgagg ccatgcagcg gcaagcttct tcttggattc tgccggccag tctgcgccgg 1111141 atgaaatgat tttgacggga ctgtcgggaa aaccctcaat ccttgcgagg gcgtctgtca 1111201 tcgtcggtac ggtatagaga acactgatgg attcacggca cagccattcc ttcgctttgg 1111261 caggagaaaa ctttttcagc aaacaaacgg ttcctccgag aaacaaagtg ctgacagccc 1111321 catataggaa gtgagaggac attaacgctc cgggaatcag aaccttatca tctgatgaaa 1111381 tcgaaaaatc tgtttctgta caggtaaagc tctccatcca tgagcggtga gatcgcgtaa 1111441 aggccttcgg ttttcctgtc gagcccgacg taaatcccat ataaaaaggg tgctccggat 1111501 caatggtagg caagggatca gcggctgcct cagaaatatc tgccatacag ttatccagca 1111561 atacaacagg tgtctggcta tctgtcagtt tgtttttgaa aaaggctaaa gtaaccacaa 1111621 gatccgcatt gcttatggac agccgctcct tacattcagc cgggctccag cgtgtgtcga 1111681 tgggaatggc cgtacatcca gccgctgcgg ctccggcaaa cagctgtaaa aacgcgagac 1111741 tatttgggag caggatcgcc acacgattcg gcatgctcgg ctgtgaccgc agccaatttg 1111801 cggtttgaga gacaagccga tcccaatcat ggtacgtgat ttgctccgat tcagtctgga 1111861 tcgctacacg gccgggcgat gtttcggcag tagatgaata ggtatgagta attgtcatgt 1111921 attgtcatcc tccttttgta aacatcgtat cagaaagaga caaggcttga gtgattttta 1111981 tcgccagaaa tgcagataca gccgctttta tcaaatcacc aggcacatat gcaaggctca 1112041 tgaaggcggc ctgtgacaaa tcaatatgca tgataaaagc ttgtaccggt ataccaagca 1112101 gataaataaa gatgatgccg aatacgatat gagtgaaaaa gagacgcaat actgtcacct 1112161 tccgcagcct gttagcggct aaactgatca gccatgaagc gaggggataa gcaatcaaaa 1112221 agcctgcgct cggtccgaaa aacacaccaa aaccgcctcg tccgccgggc aacagcggcg 1112281 ctccgaaggc gacgagcagc aaaaagacaa gctggcttaa gaaagcagac tttggcctga 1112341 gaatgctgcc tgccaacatg acaccaagcg tttgcaatgt aatcggaacg ggtgtaaagg 1112401 ataagaagag agggggcata aagccgagca ctgccatcag cgcggtgaaa atcgcaatat 1112461 gcatcatgtc gattaatttc agcatgtgaa atcctccaaa aagtaatcaa atatggttat 1112521 acaataaatg caggtaatta ttatgtcaac tgatttttaa tttaagttta cataatgaac 1112581 gcaaaaaaac cggccgtatg gcagaccggt ttttgatggt tattcttctg tcaggatgac 1112641 aagcgaatca acggaagcgg ccacatggga aacggcgcgg ctgacttcct gaagccctcc 1112701 aagaaaggct tgcagatcga cgtcgatttt gcctgattgc tctttgctga ttttcatgct 1112761 gtggacgatt tcatcgaata agcggttaat ttgcgtcatt ttttctttac tttcgctgac 1112821 tagctcattc acgtctttga tatgcttgga tacaatgttg atttgtgtat tcgtattgtt 1112881 cacaagctca gaaacagtag agacggtttt tttcgtatcc tcagaaagct tccgcacttc 1112941 atttgccacg acagcaaagc ctttgccgtg ttctccggcg cgggcggatt caatagatgc 1113001 attgagcgag agaaggtttg tttgttcagc tatgcctgtg acgatgccga agattttttc 1113061 aatttgctgc gcgatttcat ccagcttgac catttctttt tcgatttgga caaggcttgt 1113121 gtcaattttg ttcatctgtt tttgctggac ttctagctct ttttttccgc cgatcgactt 1113181 ttcttcaaca gtgctggatg ttacagtgcc ggctttggat gcttgagaaa tgccttcaga 1113241 tttgtccaca agctcttgaa ctgatctgct tgtttctgaa aacagattgg caatcgatcc 1113301 agaggtttct tgaattttct gatgaagaag gtttttcttt tcttcttgtt catcacgggt 1113361 ctggttgtac tcgctttgaa acgcttcaag gacaagctgc tgttctaagt tcaagatttt 1113421 tgttgttgct ttaatggctt ttagcagttc ttgctgattt gtaatggacg cttcataaat 1113481 gtcaatcatt gacaaaagga gctcttgaaa cgcacccata taccattttg gcaaaaggcc 1113541 gattcttaaa tggatggagg cgattcggtt acgcttttca ataaattcat catcgataac 1113601 gcctgcaaac atttcctgaa tatgccgttt taacgtttgt tttaagcggt caactgagct 1113661 gtgatcatta atgatatcca tcaatgagct ttcatggtca aggtttttat aaaacgcatc 1113721 gacgatattt acgatatttt cttgaatgag tggctgaagc tgctctaaca cataaagctc 1113781 agcatctccc aacctgacca ttttgagctg ttttttgaca tctgcatgtt tgtttgtgag 1113841 ctgaatgcgg tttttttgtt gtccgtttga atctgaaaag taagctgttt cttgttttct 1113901 gtctttttta aataacaata caatgatccc ccttgggaaa aatataattt ttactttttg 1113961 gctttttaag cctttttctt ttttatcggc caagggaaac atgaatgaag ctgcagatga 1114021 aaaatatttg aaaaaacgtt cattaaaatg aacggtttaa tcgagatcta tttgttttaa 1114081 tggtttaatg gccggaccct ctacaacttc gccagatggc ttaaagcgtg atccgtggca 1114141 cggacaatcc cacgtatgct cactgtcgtt ccactcgacc tcgcagccta aatgggtaca 1114201 agtcgtatca acgagatgga ggcagcctgt ctcatcacga aatgctcccg ctcgcctgcc 1114261 gtttatggtg acggctttcc cttctcctgg cgaaatgtct tcaaattgga catcaggctt 1114321 ttcaagcttt ccttttatca aatgcttggc gacatctgca ttgtaggaaa tcactttctg 1114381 caacccggga ttcagatgga aacgggacgg cgtgaaaatg ctttcgtatg ggttttcttt 1114441 tttctccaca aggtctgaca ataaagtggc tgcgactgct gaggacgtca tgccccattt 1114501 tttgaacccg gtcgctacta gaatattgtc ctcattttcc gacatcggcc cgataaacgg 1114561 gattttgtcg atcgtcacta gatcttgggt ggaccaataa tatggaatgc tttcgatgcc 1114621 gatggtgctt tcggccagtt gtctcagtgt ttcataatgt gtagacatgg cttttccctg 1114681 gcctgtttta tggcttactc cgctgaagag aatcagcttt tcaccgttta caaccgtata 1114741 gcggagcgcc actgacggct gatcgatact caaatacatg ccctcgggat actcgatctt 1114801 cggcttgatg gcaaggacat aagatctgtc ggagtacatt ctcgcagcat ataatccgcc 1114861 tccgtcataa aaagggaagt gggaacagca tatgataaag cggctcttaa tggcgtgccg 1114921 gctttttgtt accacttcgg gcctttcgcc ttttttgata tcaagcgcaa cggtctcttc 1114981 ataaattcgg ccgccttttt gaacaatttg ctccagaagc gcttttaagt attgaagcgg 1115041 atgaaattga gcttgattct tcatgacaag cgccagctta gaacctaagg gaattggaag 1115101 atccttgata aggtctcttt caattccgag ctttgtgtat gcctcatgct cggtgtggat 1115161 tttttgaaca gcgttttcat ttgccgtata aagatatgcg tcttgctcga tccattcaca 1115221 atcaatttga tgttcatcca caatgccttt tatgtaatca attgcgtttt ggtttgcttc 1115281 ataataaagc ctcgcatggt ttaatccgaa atggcggata aattcgtcgt atatcatgtc 1115341 atgctgtgcg gtaactttag cagttgtatg cgcagtggtt ccgttaagaa cctgatttgc 1115401 ttcaatcaaa acgacacgga agcctctctt cgtaagttca tatgccgttg tgattcccgt 1115461 aatcccgcct ccgataatgg tgacgtcaca ttcagtgtcc tcttgaagcg caggaaaaga 1115521 aggcaggtca gttgatgttt tccagtatgt ttcaggtgct tcctttgcaa aatgttgatt 1115581 agccaagccg ttatacctcc aatcagattt attcttaatt tttccatatt ctatcttttc 1115641 atacatagga agcaggcatt gttcataaca taataaggtt gaaaaggagt gatttcattg 1115701 gcgaatcaaa aaaagaaaac attaccgcct cagcaccaga accagcagcc tggttttgaa 1115761 tatctgatgg acccgcgtcc ggtttttgat aagccgaaga aagcgaaaaa attagagggc 1115821 aaaaccgcta ttattactgg aggagacagc gggattggac gcgctgtctc ggtgttattc 1115881 gcaaaagaag gggctaatgt ggtcattgtg tatttgaatg aacatcagga cgccgaggaa 1115941 acaaagcagt atgtagaaaa ggaaggggta aaatgcctgc tgattgcagg agatgtcggg 1116001 gatgaagcgt tttgcaatga tgtggtcggg caggcaagcc aagtgtttcc atccattgat 1116061 atattggtta acaatgcagc tgagcagcat gtccagccca gcattgaaaa aatcaccagc 1116121 caccagctga tcagaacctt ccaaacaaac attttttcca tgttttactt aacaaaggca 1116181 gtgctgcctc atttaaaaaa agggagctct attattaata ccgcttcaat taccgcctat 1116241 aaaggcaata aaacgctgat cgattattca gcgacaaaag gcgcgatcgt tacgtttaca 1116301 aggtcccttt cccagtcgct tgttcagcag ggcatacggg tcaatgcagt ggcaccgggt 1116361 cccatttgga caccgcttat cccggccagc tttgccgcaa aagacgtgga agtgtttggt 1116421 tcagacgtgc cgatggaacg cccggggcag ccggtcgaag tggcgccaag ctatctatac 1116481 cttgccagcg acgattccac atacgtcaca gggcagacga ttcacgtcaa tggcggaaca 1116541 attgtgaacg gataataaaa agccaatcct tgaaggattg gcttattcgc tctgcttgag 1116601 cgctgcatat tctttagaga gcgtaagaaa cgcatcttta tctttttcgt ccaaggcttt 1116661 gttaatttgg tccgtcagca tggcaagccg acggttatac aaggattcat cgagcaccat 1116721 ttgaatgtaa atatccgtca ttgtgacatc gaattctttt gttttttgcg tgttgcggga 1116781 cttcatgagc tcagtgtacg attttttctc tttcataaag aatcccccca atgccttttt 1116841 tatagtatat ggataacggt cgaaaaaatc aataaatttt tataattttt agacaactaa 1116901 tacttggcaa tctatcgaca tatcctgcaa aatgccgtaa accggcaagt cttatgaaag 1116961 taaaatcggt ttattactag tcatttagta ccattaaata tcattaaaag atgattttat 1117021 cttaaatgtt aaaaaaacct gtcgttttac aaaaacagat gatagattat tagtataaat 1117081 tttgcagaaa aaggatggag gccataatat gagtcagaaa acagacgcac ctttagaatc 1117141 gtatgaagtg aacggcgcaa caattgccgt gctgccagaa gaaatagacg gcaaaatctg 1117201 ttccaaaatt attgaaaaag attgcgtgtt ttatgtaaac atgaagccgc tgcaaattgt 1117261 cgacagaagc tgccgatttt ttggatcaag ctatgcggga agaaaagcag gaacttatga 1117321 agtgacaaaa atttcacaca agccgccgat catggtggac ccttcgaacc aaatcttttt 1117381 attccctaca ctttcttcga caagacccca atgcggctgg atttcccatg tgcatgtaaa 1117441 agaattcaaa gcgactgaat tcgacgatac ggaagtgacg ttttccaatg ggaaaacgat 1117501 ggagctgccg atctcttata attcgttcga gaaccaggta taccgaacag cgtggctcag 1117561 aaccaaattc caagacagaa tcgaccaccg cgtgccgaaa agacaggaat ttatgctgta 1117621 cccgaaagaa gagcggacga agatgattta tgattttatt ttgcgtgagc tcggggaacg 1117681 gtattagaaa aataggaagg agctgaccga acagggcagc tcctttcata aagctatgcc 1117741 gtcggaattc ctccggtgat gccatatacc tgagatgtca catagcttga attctctgaa 1117801 gctagaaata cataaacatc ggccaattcc actggctgcc cagcgcgatt taatggagct 1117861 ggcggcgtgc cttgtccgaa tttcgggatg ttttccgtcg gctgtccgcc ggaaatttgc 1117921 agcggtgtcc aaattggtcc gggcgcaact gaatttactc tgatgccttt ggaagcaagc 1117981 tgttttccca gtccgacggt aaagccgata atggcgtttt tcgttgctgc gtaatctaac 1118041 agcatcgggc ttggattata gccttcaact gaggtagttg tgataattga agctccctcc 1118101 ggcaaatacg gaagcgccgc ttttacaacc cagtaaaggg aaaagacgtt cacttcaaat 1118161 gttttataga tttgttcagt aggcagatct tcgatgtttt cgaccgcttg ctgtttgcct 1118221 gcaacgagcg ctagcacatc aagtccgccg agttcgtgat gcgactgttt gactagatct 1118281 tggcaaaagg attcgtcgct caagtctccg gggatcagca ctgcttttcg gccttctgct 1118341 tcaatcagct cttttacctc ttcagcatct ggctgttcct cgggcaagta gttaatagcc 1118401 acatcggcac cttctctggc gtaagcaatt gcggcagcgc ggccgatacc ggaatcgccg 1118461 cccgtgacaa gcgcttttcg acccgttagt ttacctgatc ctttgtagct tttttctccg 1118521 caatcaggga caggcttcat gttcttttgc aggcctggcg gttcttgata ttgttcggga 1118581 aattcatcat gaaaaaatgc ttttatagga ttcgtaagat ttgaatcaga catcagcaac 1118641 gctccttttc tgtttggtgt acattcgtat gtgtacccct gagcataagc agaaaaacat 1118701 gttttggcag tttgaatagt gaaggaaaaa gaaaacaaga aaaaacaaag ccttcttcca 1118761 tatttatctt gtcaaataag actatatgaa ttatgataaa ttcgagctat aaatcaacta 1118821 aatattgggt gttgggagag tgaatcgtca tgaaaaaagc ggcggcggtt ttgctgtcac 1118881 tcggtctcgt tttcggtttt tcatacggag ctggccatgt ggcggaagcc aaaacaaagg 1118941 tgaaggtcta taagaactgc aaggagctaa acaaagtata caaaggcgga gtggcccgca 1119001 catcgaaggt gaaaaacaaa ggcggaaaaa cgaagtacaa gccttacgtt tctaaggcac 1119061 tttacgatgc caataaaaac aaagaccgcg ataaagatct tatcgcctgt gaacggtaaa 1119121 taagaaaaag caatctggtg tccagattgc tttttttatg cttaggccgc ctgatcggcc 1119181 gcagcgcttt tcgccttcct tgtcataagg ctgactgcca tcatgaccgt gatattcaaa 1119241 agcagggcga cgatgccgac attcaagtct tttgcggctt gcggcagagc cggaaataaa 1119301 gtgccgatcg tcgtttccgt cattgtaata taagtaactg ctccgacacc tgcaataatg 1119361 ccggcgaaag ctccttgctt tgtcaccata ttatgcttga gcaggctgaa caaaagggcg 1119421 gggaatagct gtgtgacaag gctgtagccc atcaaaagca gcgtaacgat ggtattcccg 1119481 cctttgaagg taaaatacac cgaaatcagc gcaatcaccg gcactaaaaa cttagcaagc 1119541 gccgatactt gctgttctgt cgtgcggggc gcgattacct tgtacacatt ttttgcaaac 1119601 agtgtggagg cggacattaa gatcatagac cctggcacaa gtgctgtcag cagtccggca 1119661 gcaccgataa ttccgacaaa ccaagggtca aatgcttgca gagacagtct caaaagcgac 1119721 aaatccccgt ctgcgccatt cagatctgga acttgcagga tagccgcaaa gccgacgaaa 1119781 aggacgaaga gcaggaccag ctggtacaaa ggcatgatga tggcgttttt acgaaacact 1119841 tttgggtttt cggctgaata cgaagcggaa aacgtgtgag gccacatgta aaaaccaagc 1119901 gctgtcaaga gtacggttga actgaaccag gccacacttt gtcccgattc ggggagcgta 1119961 agaaagccag gctttgccgt ttcaatctgc tgaaacatgt cttgaaatcc gccgtagtaa 1120021 tgaattggca aatacacacc taaaaacaga acgacaacca gaatcatgat gtccttcaca 1120081 accgatatcc aggcagaccc gtgaatgcct gaaaccataa cataaaccgt gatggaaaca 1120141 gcgccgatcc agatggcagc ggtcggggtg attttgccgt acgaggtttc cgatacaatc 1120201 agcccgaggc ctttcagctg cagtacaaga tagggaatga gtgcggcgat gccgaccagt 1120261 gaaacgagaa tgccaagcag cggactgttg tatttttttg tgaaaaaatc agactgcgac 1120321 atcagtttat gctgtttcgc gtacgtccaa actgctggaa gaagccagta agaaaggatg 1120381 taggccagac atccgtaggc gatgatataa aaggctggac cgccttttcc gtaggcccag 1120441 ccgctgccgc cgagaaacgt aaaagtagta taaatttcgc ctgccatcaa aaggaagacg 1120501 aaaacagttc cgaagccgcg ccctccgacc gtccactgct ccaggttcat gtcttttcct 1120561 ttttgggcgc gtataccgag aaaaatactc aagagcagga caccgaagat gatgatgaga 1120621 gctgcattca ttctgcttcc tcctttttat tttccttgtc gaggacatac acaatcgcca 1120681 tcagcgcaga ggtcaaaaga gcccacatca caatataggc aagaataaac ggcatgccga 1120741 acacataggg ggtcacctta tttgcaaaag ggatgccgag taagattccg ataaagggta 1120801 aagcggcaag aacgtgaatc agtttcatag aatcctcctt ctatttagga ttgaggtgta 1120861 caagcctaag cgtactgaaa atgatgtcgc agatatcgca gcacatgtca ttttttggag 1120921 tgaaaggctg tggttcgaat tataaataaa tttattttgt ttgtatagtg tgaattgtct 1120981 gaaattaatg ctctgaatcg cccgaagagg gaacgggcag tatgattcaa aaggctcaga 1121041 gtctgtctgg ggcaaataga tagtatgtta ataattcgct gacctgctca cggattcgcg 1121101 gattaaaata gcgatggttt tcttcataac cgtcgatgac aaatgtatag agtgtaaagg 1121161 cctcatcgcg ttccgtctcg cggattgcaa tttttctttt cctcagttct tttctgacct 1121221 ccatcaaatc cttttgtgct atttttaatg attcgctgat aagctgttta taaggatgct 1121281 tcaattttaa tgtgctttct tcaattccgg cgagatcacg gttaaaaatc gtaatggcca 1121341 tgggcaaaaa gagagcccgt tcaattaaat cgtatatttc ctcctgcaga tttggcatat 1121401 tgactccttc tttctaaggg aacgtttgtt ctatttgtat tctatatcgg ctggtgaaat 1121461 gtttcaagac agaaaaaatc accaaaactt tttagttttc tgctgataat gtgtagaata 1121521 aggatagaca aacccggtaa ggagtataaa tgttggagca ttttttatcc tatttgacac 1121581 aagaacattt aactgaatta tttcaaagct atagggcttt cggtccgctc attgctgtgc 1121641 tgctgccttt aattgaagca tttctcccgt ttttgccgct gatcgtgttt gtggtggcga 1121701 atacgaactc gtttggcttg tgggaaggat tcatcctatc ctgggcggga tcaactgctg 1121761 gttccattct cgtctttttg attgtccgtc aatacggaca gagaaaattg cttggattta 1121821 tccgcagtca tccgtctgtc agaaagctga tgttatgggt ggaaagacac ggcttcggtc 1121881 ccatgtttct tctgctttgt tttccattta caccgtcagc cgcggtgaat gttgttgccg 1121941 gtttgtcaag gatcggaacg cggccgttta ttttggcggc agcctcgggg aagcttgtca 1122001 tgatttttat gatcagcttc atcggatatg atctgcacgc gctgattaca cagccgattc 1122061 gaacggtcat cgccgtattg gtgatcactg tcttatggta tgtcggcaaa aaggtggagc 1122121 ggtatctgca tgtaagagcc agtcagcgtg agcatgatgg agggagacag taacatgaaa 1122181 aaacggtttt ggtttcttgc cggtgtagtg tccgttgttc tcgccattca ggttaaaaat 1122241 gctgtcttta ttgattacaa ggtagaaggc gtcagtatga acccgacctt ccaggaagga 1122301 aacgaattgt tggtcaataa attttcgcat cgatttaaaa ccatccatcg ttttgacatc 1122361 gtccttttta aaggccctga tcataaagtg ctgattaaac gggtaatcgg cttgcccggt 1122421 gaaacgatca aatataaaga tgatcagctg tatgtgaacg gaaagcaggt tgctgagcca 1122481 tttttgaagc atttgaaatc tgtttctgcc ggcagccatg taacgggtga tttttctttg 1122541 aaagatgtga cgggaacaag caaggtgccg aaaggaaaat attttgtcgt tggagataat 1122601 cgcatataca gcttcgacag ccggcatttt ggtccgataa gagaaaaaaa tattgtcggt 1122661 gtgatttctg atgccgaata aaaagacgct aattgaagag gcgtcttttt gtatgccgtt 1122721 tggaaaaatg tgttgaagaa aaatttgtaa ggagctataa tcaaaattgt tacctgtgta 1122781 acaaaattta tatatttttt tgactggagg gccgttttta ttggtttttg ttcgtttttc 1122841 atgaaacaaa aggagtggtg aatgatgatg aaatatgaag cagtgattat aggaggaggg 1122901 ccggttggat ttatgctggc ttctgagctt gcaatagccg gagtgggaac atgtgtgatt 1122961 gaacggcttg aaaaacctgt tccgcattcc aaggcgttga cgctgcaccc ccgaacgctg 1123021 gagcttcttg agatgagagg gattttagag cggttcgtat ccaagggaag caagatacct 1123081 accggacatt tttcaatgct ggatacccgt ctggattttt caggcttgga tacgagctgt 1123141 ccttacacgc ttttgctccc gcagtccaaa acagaaaagc ttcttgaaga tcatgcacga 1123201 agcctgggaa cagaggtgtt tcggggtgcc gaggcgctgg cggttacgca aaacggggaa 1123261 gcggtccaaa caatttttaa ggatcgggac ggcagtgtac ggacgatcac aagcaagttt 1123321 gccgttgggg cagatggcgc cgggagtacc gtccggaaac aggcgaaaat tgagtttccg 1123381 ggaacagaca gcactgtcac cgctgcgctt ggggatgtgg tgctcctttc tccgccgccg 1123441 tcaggtgtgc tgtccctttg cacaaaagag ggcggtgtta tgattgttcc gttatctcca 1123501 gaccgatacc gtgtcgttgt gatcagccct tatcgcacac aaacgccgaa agatgtgcct 1123561 gtgactgagg aagagctgaa agctgacctc ctgcgaattt gcggaactga cttcggttta 1123621 accgaccctt cgtggatgtc gcggtttggg aacgccgcgc gccaagcgaa acggtatcgg 1123681 gacggcagaa tctttcttgc gggtgatgcc gcgcatattc attttccggc gggcgggcaa 1123741 ggactgaatg tcggccttca ggatgcaatg aacctcgggt ggaaactggc ggcggccatc 1123801 aaaggctctg cgccttcttg gcttttggac agctaccatg atgagcggca tccggcagcg 1123861 gaagggctcc tcagaaacac ggaggcacag acaaagctga tcgatttcac tcaagcaggc 1123921 ctccatttgc gaagcatgat gtcggagctg ctggccttcc ctgatgtgaa tcgatatgta 1123981 gcggggcaaa tttctgcgct cgatgtcaga tatgaagctg atcgtaccat gccgccgaat 1124041 cgtttgaacg gggcaaggct ccctgacatg aagctgattc tttccgacgg caattcggaa 1124101 cggctgtaca gctttctcca aaacgggaca ttcgttttgc tgtcattgag gcaggaagct 1124161 gatgatcata tcgaagtaaa aggcttacgt acggtaaccg cctcgcttgc agaaccgaat 1124221 gaaaagttgc ggaatgtgca taccatattg attcgtcccg atggacatgt agcctgggcg 1124281 gtggatgcat cagcgcccga ttgttccgag gtgattcaaa aagggatcag ccgctggttt 1124341 tccgtcacca gccgagtata attcaattcg attgtttcat ctgtaacaaa acggtatgat 1124401 agaagaaaca atcgaatgaa aaaggatgga aaacccgatg aacacagatc atacgaaacg 1124461 caatcttttt gaattgtatg cggagctcat tcatcagcag gagaaatggg aggggcttat 1124521 taaagccttt ttatctgacg aattgaggaa gctggatgta gagcacggga gtaaatctca 1124581 attgacgatg acagaaattc atgttctatc ctgtgtcggg gacaatgaac caattaatgt 1124641 cacgtcgata gcagaaaaaa tgaatacgac aaaagcgact gtatcacgca tcagcacaaa 1124701 attgctcggc gcaggcttcc ttcacagaac acagctcagc gataataaaa aggaggtcta 1124761 cttccgattg acgcctgctg gaaaaaagct gcacagtttg cacaaatatt atcatcagaa 1124821 ggctgaacag cgttttctgt cattttttga ccgctatacc gaggaagaga ttctttttgc 1124881 ggaacggctg tttcgggatc tggtgacaaa atggtatccg tcgtcagaag aaattgaagg 1124941 ggggcttcct agcattttta aataaaaaac acgcactgcg gtgcgtgttt ttcgctttgt 1125001 ttctatcttt ttcaaggctg taacgtaaat cagatttcct cttgaagaat gaaattcaag 1125061 atgttcagga atttgcactg cttatacgat atgtctatta gtatctttat tttatacgtt 1125121 ttctactgtg tttttgatgc tttgttttca agtgaaatag ggtcttctgt tttagttctc 1125181 ctaatcttta cagaaatacc tactagaatg accgccatag ttgtaaatat tcccatggtt 1125241 aataagatcg tatcctggtt taaactccat ccaattaaga aagagatgat cgctcctccg 1125301 aaacttgccg aggcaataaa taaacttgta acttcgtcaa cgtacttctg aataatgatt 1125361 gatgctagtg ttaaagcaat gggaaatatc cccgctatac ttaggccaat caaaaatgta 1125421 ccactcaatt gaagtattgg gttacttata taagagaagg caatcaacaa aacaattaaa 1125481 caactacagc taaaaagaag gtatttggaa aaatcaagcc ttctacttac gaaaccaatc 1125541 aatattcttc ctatgatgat ccctacccag aaaaaggaga cacttataag actaatttgt 1125601 tcattgtctt ggtttatcat gattgaaggt aaaaagttgg caaaatttgt ttcaattcca 1125661 gcatatagga aagcgaaaaa tacaaaaaag cctaattgct ttgatttttt tctatctcct 1125721 ataaagtatt gaaatgctcc tccatctgga aaggtcactt gttggttagc attcttagcg 1125781 tactctcggt tcttagacaa gaaaattaac caccctacga ataggacgaa taaaaaggtg 1125841 aatatacagt aatatggtaa aaaccagtta ttgatatcta tgaaggaatt aattaataat 1125901 gggaaagata aagcgcctaa tccaaagaga acttccagct tactcatttt ttctgcatta 1125961 ctttcgaaat tagcaataac aaatgaacca actgtcgttt ctaatgtgcc tgctccatat 1126021 cctaagagaa aagccattac aataatataa taccaatcct tggttagaaa aaagatactt 1126081 aacgctacaa gcattattgt caaagctaaa gtaagtgtcc taaaatgact gtatttctta 1126141 atcattaaag gtgcgattaa tactccgctt agaaatccgg taaactggaa gaagattatg 1126201 accgaaatat catctgttgt cttgttaaaa gcctctaata aaaatggtgt caaactccct 1126261 gttgatatat ggataatacc tactgtaaaa aagaaagcat atccaaataa atatgtccct 1126321 cttaacattc attacacccc tatatgaaaa agcaggaaag taaattcctg cttttttagt 1126381 aacttctctc tttgaaatac tagttgactg ctgaaacaga catgggttga gagttgctgt 1126441 ctttctcaaa gaacatttct aatacttcct gagatctaaa accatcacta aaagaaggga 1126501 tctcaaccca atcattctga gttgatgcaa tccaattgat taactcgctt ctaaaagaat 1126561 cagcccatcc ataaaactcg tttggcggat cgtttaatag gctttgcggt actgggcagt 1126621 ctaccacgtt caagccatct atgagcttgt aaacgtgagg attacctgtg tggtatttaa 1126681 actctttttt gtgtccaact acctcaatgc taaaaccaca gtcttcaggt acagaacact 1126741 ttgatgtgat gatatttaca aataccttgt tcttcagctg gccataaatt tctgcatagt 1126801 catctacaag tacctgttta tcctcttttg tttttacatt tgtgttcatc tttgccctta 1126861 ctgattctgt gatgaaatca ctctcgaaca aataccatac catgtcaata aggtgaatac 1126921 ccagatcccc caatgatcca ctcgtcttct tactattagc gtcatctctc caagtaaact 1126981 tcttacgtct aagtgcacta tttttcttga agtgtacttt tatggacagt atgttaccta 1127041 gttcattatt gataattaag ctttttaaga tatttacgta agataaatat ctataattaa 1127101 atcccatact ggctcttacg ctcaaccttt cagcagtatc tttcattatg cttgcttctt 1127161 caagagaaat agccataggc ttttcacata atacatgctt atgttttcct aatgcttgca 1127221 aagcatgttc tttatggcaa aagtttggtg atgctacaat taaaccttct gaggcatcaa 1127281 ttagttcatc tacgttttca aatgacttcc cgccgaaagt tttcacaaag ctttccgcat 1127341 tttgttgatt tatgtcatat acccctacta actctgcatt ttttattgta gataaagcag 1127401 ttgcatgcgc tcttgcaata ccacctgcac ctatgatgcc tatcttcttc atttttattt 1127461 cctcctcatg atccaattaa tttttttaag gtattagtaa ttccttttga gtactcacta 1127521 tcagttataa ggttgtgcaa gtttttggct tcctgtgttg cattttttag cagatatcca 1127581 ttccctactg tctgtaacat acgaacatca tttccactat ccccaaatgc gatagctctt 1127641 tcggtattta ggttgtattt ctctaacata aacgttacaa tttcattctt tcctgtccct 1127701 atggggataa aatctacatc atagctgtct tctggatcgc ctgctaaggg attacaccga 1127761 tttatattta ctgaaacgcc gtattcttcg cagatttttt caatagctaa taggtttttc 1127821 ttgtcgttta tttcatcttg ttcctgatag tagaagttat gcttataccg tgactttcct 1127881 aattgggttt gaggattcaa aagaatgtta tgattttcat gcagctgttt cacaagtttt 1127941 tcaacctttt ctttactaaa cccttcattt atgcgactgt tccacttgtt atcttgctga 1128001 ccgaagttat gctctgaaaa gtacgtaatt tcagttccaa gatcactagc tataaaatgc 1128061 ggaaaatatc taaattttcc tcgtcccatt ttatcgagaa tagattctat actgctccca 1128121 gtaacccatc cgattattag ctccccatct ttactttttt gttctagata gtcttcgagt 1128181 tcatagatgt cttgttgctt ttgttcgtcg attgtatgcg gaaaatacgt ttcatcaaaa 1128241 tcacaaaaaa caatatattg aggatgttca accgtggata acgttttata ctccgatttc 1128301 ttgcttaata acatgaaaca gtccctccat tactctgtct tgttcttcta aagtaaatga 1128361 cggatataaa ggcaaatgca gtacctgact atgagccttt tccgtatgaa ccaattggag 1128421 tcctgcatac ttgtcctgta ctaaaggagt tttttgcata tgagaaagta ttggataata 1128481 tacatctgtt tgaacaccaa aatcttcatt taatttagtc atgatatctg ccctatcttc 1128541 tgttcttacc ttaataggaa acagatgcca tacatgatct tcacttaatt ctggtaattc 1128601 aatatagcct ttattctgca actctgctaa ttgggtaatg tatctatccg ccaagaacaa 1128661 tcttttgaag ttgtttaatg aaaggtactt cattctctct aaaccaattg ctgcctgtaa 1128721 attgtccatt tttgaattaa atccaaaatt gatgactttc ttatttttta catttacttc 1128781 aaaaccgtga taactaaatt gaatgcattt tttagcgagt tcttcattat cagttgctat 1128841 tgccccagcc ttgccacata caccaaaatt cttataggga ttaaaactta atgtagtgat 1128901 gtctgcatac tttcctaagt ctgtcagtcc aattccttgg caggcatctt caattacttt 1128961 taatttataa cgatttgcga tttgacggat atgctgcatg tctgaatgtt ttccgtataa 1129021 atgcacaggt agaataaact ttgtataagg agttattgct tcttcaattt tgtcaggatc 1129081 gatgcagaat gtttgtgggt taatatctac atagatagga acgcctcccg aagctaacac 1129141 agcattttca gtagctgaaa agctattagc cggcatgata acttcatccc ctgggtttaa 1129201 ccctaaagcc aataaaccta tcataatagc atcggttcca ctgctggttg caattacata 1129261 ccttttatgt aaatatgtag ataaaacttt ttcgaattgc tctaaatagg gaccactcgt 1129321 aaattttcca gttggcaaaa cttcagttaa tgtatttaag atatcttcca cttcatcatt 1129381 ggttattaat ctgtctacag gcaaaaaagg gactttactg atttcacgat ttttttgata 1129441 gttgaaaagg tcatgttcaa tatctatctt ttcttttaat acttgtttcc accgctcgtt 1129501 tacaatactg tcttcaataa caagttcttt tccttgtacg tcacctttta agtgttttaa 1129561 tagtgacatg ttttctttgc ttttacctga aatcttaacc tgtttttgca tgaacagtac 1129621 ctccaatgat tttataatct aaaaatttat tacaaattta tcctagtttc tgaaatcggt 1129681 aacatgtcaa caactttttt aaggaaggga aaatatgcct acaattgatg aaatagcaaa 1129741 attatgcaat gtgtctaaaa ccacagtgtc aagagtattg aataatcatc cttatgtgtc 1129801 gaaagaaaaa agagatatga tcttaaaggc tattaacgaa cttgactaca ctcccaatta 1129861 tttagctcgg aattttagga gaaataagac acaaacgata gctttatcgg ttccgagtat 1129921 cgaccatcca ttttttgctc aattaataaa aggggtctct catgaagtac tgtttaagaa 1129981 ttacaaggta attgtatttc agacctttta tgacaaacag acggagctag aattactaga 1130041 gttattgaag cataaagaag tggatggcat tattcttggg actttagaaa atgaatggga 1130101 tcagatatcc cctttcttaa agtatggtcc tatcttatta tgtaatgaat atcatcactc 1130161 agcggacatc acgataattg ggtatgatga atttgaagcc gcatacatgg gggtagtaca 1130221 tttaattgaa agagggcata aaaaaattgg gttttgtttt gatactccat atagcgaagc 1130281 tcaatgtcag aggaaagagg gttatttgaa agctttacaa gattacaatt tacatcatag 1130341 aagcgaatgg atattcggcg aaatgtttaa tatcgaggat ggctttcgtg tttttcataa 1130401 gataaaggat ctaaaggaca gaccctcagc aatatttaca ggaaatgatc aagtcgccgc 1130461 agggattatt aaacaggcga tgaaaaatgg ctttaaagtt ccagaagact tagctgtaat 1130521 tggttttgac aaccaattga tttgccaagt cgttactccg accataacaa caattgatat 1130581 ccccgtaata gaattaggcc aacaggctgt gttgaaaatc atcgagtcca tttcgggtaa 1130641 tgcctcttta aacagaagaa ttattaaact gccaacaaag cttattataa gagaatcaac 1130701 gtaacgatag atttcccttt aacattttat atctttatat aagaaaaaga ggttattcat 1130761 tttaacctct ttttcaatcg taagtcgtca attatttctt tcatttcacc ctctggcagc 1130821 actcacttca aatctgatcc attaacaacg aaatatccgc ttatatttcc tcatctcgat 1130881 ggtttgcgaa ttaaaagttc ttgaaccctt ttttcaacta ggcactactg ccgctgattg 1130941 agctcttttt gtcttttttt tcaccatgaa gatggtgaag caggcgataa aacggcggca 1131001 gcagggcaat aaccagaatg acgcgaatga cctgaaccgc aacgacaaag gtggaatcag 1131061 catgtaaggt aactgacgtc gtcgccatct ctgcaatccc gccgggcgca aatgccagaa 1131121 cagaagtgat gagcgaaatt cctgtcagct cggaaacgat cacggcgctc aaaaacattg 1131181 ctgcgattaa accgacggac gagacaaacc cgacgatgat aatacgggtg acgccggcaa 1131241 acatgctttt gtacatctta gagccgatcg ttgccccgag aaatacttgt gatacatggt 1131301 tagcttgtga caaccaccat gccgtcatgt cgtgccctgt caccgcagct ccgccaacat 1131361 gtacaattgc tacaccgagc atgctgccga gcagccatgg agctggaaat tttaaaaatt 1131421 tcgcagcttt gcaagctccc caggcagcga gaataagaat gacggtccac aaaacgggag 1131481 cgagcctaaa atctgtcgtt gcagaagaaa tcgtctctgc tgcggcactt gcggtacgat 1131541 cttgttttgt atagatcaga atgactaaaa acggaatgga aagcaccacg agcagcacac 1131601 gcatcatttg aacgaggctg actatagcgg tattggcgcc tacttcctgt gcgatgctcg 1131661 gcatggcgga aagtccgccg ggagcggtgc cgacaaagct agtcatcata tccgttttgc 1131721 tgaaacgcca aagcacatat cctgacagca tggccagcag gatagacaat atcagcataa 1131781 cgccgactga aaaccaatgg tctttgagaa cagagagaac ggataaattc agcttttggc 1131841 ccaattcgat gccgaggatc atctgcccga gggcgagcca tcgtcggtta attccttttt 1131901 ggtctggtgc catcatcagc catgccggcc gtatcatggc gaggcagcag gcgacaatca 1131961 gtgttccgat catccatcca attgatattc cggttaatga aagaataaac cccccggctg 1132021 cactgattgc gataaaccat agatctttga ggagattttc gtctttcttc aatgtaaaac 1132081 ccttcttcct ttttcacgta acactccaat tgttcacgta gtgaatgtat ttattactat 1132141 agtatatttt tgttgataaa gaaattatga attattttct ataagcgatt cacttttctt 1132201 atgaccttgt gttcgagctt ttctattgtg taagtcagag ataaacccgc tgtcagcaga 1132261 cacacggcaa gagcgtaaaa aatcacttct ccgccaaatg atgtcaggat cagcccgcct 1132321 gccagcggtc cgattgagcg ggatatatcc caatgcagac catagacagc ataaaaccgg 1132381 cccagcaaat gaggcggcgc caatttcgat atgaaggtct ggatgtgggt tagcccgatg 1132441 ctttcaccaa ccgtcatcac cgctgccgtc actaaaagca ttgtcagaga ggttgagcat 1132501 gcaaagccgg ctgccgcaag ggagtagcaa atataagtaa tgaagaggat cgttttcatt 1132561 gaaagctttt cggtcccttt gacaagaggt acttggagaa cacagctgaa taaagctttt 1132621 gctgctgaat agatggtcag catggacaga taatcagaaa acatgttttt gctgaacagc 1132681 ctgtatgttg tttctgtttg tgcatataac atgctgatgg ggagagaaag cagcaaaaga 1132741 agcaggacag gcctgtatat tgtaaagctc gcggacattt tcggggtaac agctgggtgt 1132801 agcggctttg tctcaggcag tttcagtgca gcgatcagaa agtagataaa caatgctgca 1132861 gcatctaatg cgaatatcca cacggggtta tgattgtaca gcagcatccc cactagcggt 1132921 cctgccgtca gacccgtcga atagatcgca ttgatgaccg caaacacttc cgaacgtctg 1132981 ctttccggcg tgctttcagc gatttgggcg cgggaagcgg gaatgtacaa cgatcttccg 1133041 atgccattca tgacatagag aatagcgaaa acatacgcat gctcagcaaa tacaaaccct 1133101 gtcattgccg ctgattgaag aagcaatgcg gtcaaaatcg ctgtgcgccg cccaagccga 1133161 tccgtcaccc gtcctgcagc gagcgtcagg aaaatatcag caaatggctg aaggctgatg 1133221 atcagcattg gcatcatgat actgccgttt aattgttcat gcagatacag caccataaaa 1133281 ggtcccatca ttgcacctgt caggcttgtc agcaattcgc cgaaaaagcg gagccgaacg 1133341 ggagcggtat atctcgattt tatagagtga aaactggtca acatgtgatc gccgcctttc 1133401 gctgtttgat atagtagtag tgtatagaag gggcggcggc ccaaaaagtg aagaaaagaa 1133461 gagataaaag ttcccctttt gtcgggaggt gcggggattg aagctgatag agcactacgt 1133521 ggcgcttgta aaaacaggct gcgccgagta tgggcaaatg aacgaaatga cgctcactga 1133581 gattgccgac tgtttatttt gtacagaaag aaatgcaaag ctcattttac ataagctgga 1133641 gaacagcaat tggattatcc gggaaagcgg ggcggggcgc ggccgcaaat ctaaaatcgc 1133701 gtttcttcgg aggcctgagg aactgcttct tcaaactgca aaggaatata ccatgtcagg 1133761 aaagcttaaa aaggcaaagg agctgcttca gcagtatcag tccgcgtttc cagggcttca 1133821 aaacgaatat aacatgtggc tatcagaggt attcggattt gtgacggaga caggcgagaa 1133881 tggggcgaag gatgtcctgc ggctgttcat cacgcctgaa tctgtcagca gtttggatcc 1133941 atgccaaata tttttgcggt ctgagggcca tttcgtcaaa cagatatttg atacactctt 1134001 cacgtttgat tcggatatgc aggagccgaa gcctcatttg gttcatggat gggaagaggt 1134061 cggaaaaaaa caatggagat tttttcttcg aaaaggtgtg ttatttcata atggacagcc 1134121 gctgacatcg cgggacgttg cgtttacatt tcagcgcttt ttggaactgg ctgacaaccc 1134181 gtataaatgg cttctgcacg gagtgaaaca agtcttagaa aagggccctt attgtgtgga 1134241 gctcatactc gataagccga atgcgctttt gccgtatgct ctttgtgatg aacggctgtc 1134301 catactgccg gcagaacagg gcggcgggaa aaatggaaca gggccttttc agatgaatca 1134361 gcaacatagc gggatgcttg tgcttgaagc caatgagcgc tacttcaagg gacgccccta 1134421 tttggatcgc gttgagtttg tgttttctga gcaagccgga gagatgaacg gttttaccat 1134481 tcaagaaaaa caaacatgtc ctgagcagca aactgtcttt gatgagcggc atgttcagta 1134541 tttgtcgctt aatctgaaaa agaaggggcc tcttcagcac cgaagcttta gaaaagcgct 1134601 ccggctgctg atttcctctg aacggctcgt tcgtgaagcg ggagggcacc gaagaattcc 1134661 ggttacgtcc tttttgcatc cgagtccttt tgagtgggag ggcgtttcgc catctgaatt 1134721 gttgaaaaaa agcggatacg agggcgaaac aatcgtgctt tatacctttt cggaaacgga 1134781 tcatcgtgag gacgccgaat ggattcaaaa tatttgcgcc cagcacggta tcaggcttac 1134841 acttcaattc tgtgatgctg ctgatctgcg acggccggaa atcgtgcaga tggcggatat 1134901 cattcatgac agtgcgacgt tttatcaaga cagcgagttt ggttttctgc atttgctgct 1134961 gtcggagaac agtttcttgt atcagcatct atctgaaaag ctgacacaga tttgctcagg 1135021 aatgacagag cggatgtttt ccatgcctga ccgctgttcg agaatcaaca tcctgcgtga 1135081 cattgaccgg cagatgatac aggagctgaa cgcgatcccg ctgtatcaaa atgtgctcca 1135141 ggtgacatca agtaaaaatg taaaaggcct ggtgcttgat gaagagggat ggattgattt 1135201 gtactccgta tggctgtcca aataaaaaga gggttctttt ttgaaccctc ttttttacgc 1135261 tgccatgctg cggcattgtt cagcacaggt gaagcaggct ttcgcacatg cttggcaatg 1135321 atcatgatcg tgctttccgc attcagtgcc gcatgcttca caaatatcgg cgcaaagtgc 1135381 acaaatttct ttcataaacg ggctgtccgt ttgcatggct ttgaccgcca gcgcgcaaat 1135441 atccgcgcat tccctgtcaa gccggatgca tccgctgaga tgatgctgca cgctttcttc 1135501 caagcattta gtgaaacaat gattgcaagc cttcatgcaa tcgatgcaag cctcaataca 1135561 agcctcagaa tattgctcca tggttgattc cccctgtatg acagtatatg gttttatgtt 1135621 tcacggctgc atttgaaaaa aacaggggag tgtgttttta gctaagggga tatgtacata 1135681 taccctgaat gggtatatct aacgttccat cagatagtat aggaaccaga cagcgtgatt 1135741 ttgttcatca cgtgctgcgc gcgtaaagac gcctttcgct tttaagtttg acgtttcctc 1135801 ggccgcacgc aagtaaaagt cgacggtttc ttgttcatct ttaaaagcgg cgtccagtcc 1135861 tcttgtgaaa ttgtccgggc attcttccgt ttgtttcggc atgatgtgtt tgccggtaat 1135921 tgaaccatac agtgtggaaa attcacggag gtggcgaatc tcgtcacgcc tgatttcttc 1135981 aatctgtttt ctgacctcat cgctgtgggc gagttcggca agcttgcggt agcattgaat 1136041 agcactgaat tctccgttga tggccttctg caaattccga atcaaaacag gatcttcccg 1136101 gtatggcacc ggatagggat agtagctgta atgcaagggg attcaactcc attcttagga 1136161 attgggcttc tgtaaaagta tatgttgggc agggagagat gtgcggagat aatcagcttt 1136221 ttatatgtga aaaggccgtt tttaccaata gatcagattg gtcattttcg tcaacattcg 1136281 ataaaatata gagagataaa aagagagggg tcttctaatt tgggagcaga gtttttagta 1136341 ggcaggtccg ggagtggaaa aacgaagctg atcatcaaca gcattcagga tgaattgcgc 1136401 cgggctccat tcgggaagcc gatcattttt ctagtcccgg atcaaatgac gtttttaatg 1136461 gaatacgagc ttgctaaaac gccagatatg ggcgggatga tacgcgctca agtgttcagt 1136521 ttttcacgat tggcctggcg cgtcctccag catacgggag gaatgagcag gccgtttctg 1136581 acgagcaccg gcgtacaaat gctcctgcgg aagctcattg aggagcataa acaggagttc 1136641 aaagtctatc aaaaagcgag tgacaaaagc gggtttaccg cacaggttga gcggatgctg 1136701 acagagttta agcgctattg tctggaaccg gaggatatcc gccggatggc ggaaagcgga 1136761 acggcttccg agtatcgcgg agaacgtgtt ttatctgaaa agctccatga cttatcaatt 1136821 ctgtatcagc aaatggaaaa aagcctcgca gatcaatatc ttcactctga ggattatttg 1136881 acattgctgg cagagcatat cccgcttgcg gaagatataa aaggcgccca tatctatgtg 1136941 gatggctttt atcagtttac cccgcaggaa ttcagggtgt tggagcagct tatggttcat 1137001 gcggagcata tcacgttttc gctcacagcg gacaagccgt catatgagcg ggagccgcat 1137061 gaactggaat tgttcagaat gacggggaaa acctattacc gcctgcatca gaaggcgaag 1137121 gaactgaatt tggacattac gtataaagag ctgagcggga ctgagcggca tacaaagacg 1137181 ccggaattgg cgcatctaga ggcacagtat gaagcgcgtc cggccattcc atacgcagaa 1137241 aaacaagaag cccttactgt gatgcaggcc gcaaacagac gagctgagct ggaaggcatt 1137301 gctcgggaaa ttcacgccct agtcagagag aagggatatc gctataagga tgtagcaatt 1137361 cttgcgcgcc agccggaaga ctacaaggat atggtgaagg aagttttcgc agattacgag 1137421 attccttatt tcattgacgg aaaagcatct atgctgaacc atccgttaat tgaatttatc 1137481 cggtcgagcc ttgatgttct gaaagggaat tggcgttatg aagcggtgtt tcgctgcgtg 1137541 aaaaccgaac tgctattccc gctcaatgaa ccgaaggcca aagtgagaga acaggtcgat 1137601 cagctcgaaa attactgtat cgcctatggt attaaaggcg accgctggac aaagggcgat 1137661 cggttccaat acaggcgttt tgtgtcattg gatgatgatt ttgcgcagac tgatcaggaa 1137721 atcgaaatgg aaaacatgtt gaatgacacc cgcgattgga ttgttccgcc gctttttcag 1137781 cttcaaaaac gcatgaaaaa agcgaagacg gttcaagaga aggcggaggc gctctatcgt 1137841 tatttagaag agacggatgt gccgctgaag ctggatcagg aaaggcagcg tgctgaggat 1137901 gacggcagaa tcattgaagc gcagcagcat cagcaggcgt gggacgcagt cattcagctg 1137961 cttgaggagt ttgttgaaat gatgggagat gatgagattt ctcttgattt gtttcagcaa 1138021 atgatagaag ccggcgcgga gtcgcttaca ttttctctaa ttccgcctgc gcttgaccag 1138081 gtgtttgtcg gcaatatgga tttgtccaga atgtatggca cctcctgcac ctttgtgctc 1138141 ggggcaaacg acggcgttct gccggcacgc cctgatgaaa acggggtcct gtcggatgat 1138201 gaccgggaat ggctgaaaac gattggggtt gagctatcct caggcggacg agagcgtttg 1138261 cttgatgagc acttcctcat ctacatggcg ttttcaagtc cgtctgaccg gctttacgta 1138321 tcgtatccga ttgctgatgc ggaaggaaaa acgcttttgc cgtcgatgat cgttaagcgg 1138381 ctggaagaac tgtttccgca tcataaggag cgcctgttaa caaatgaacc tgaacaggtc 1138441 agcgatgagg aacagctgat gtatgttgtg aataaaagcg tggcacagtc ctttaccgcg 1138501 agccagctca ggttatggac tcgggaatac gacatcagcg acgtctggtg gagcacgtac 1138561 aatgtgctga tgagtgagca ggacaggctg caatcgaaaa agctgttctc aagcctgttt 1138621 ttccggaatg aagtgaagca gcttgaacgc agcgtgtcga gacagctcta tggtgaacgt 1138681 attcagggca gtgtatcgag aatggaaacc tttaacgcat gcccgttttc ccattttgcg 1138741 tcacacgggc tgcatttgaa ggaacggcaa ttcttcaagc ttgaagcacc ggatatcggc 1138801 cagctgtttc attccagctt aaagctgatt tcggacaggc tgcgtgagca aaagctggat 1138861 tggcgcgatt taacgaagga gcagtgcgag ctgttttcct atgatgcggt agagcggctg 1138921 gcaccgaaac tgcaaaagga aattctgctc agctcaaacc ggcattatta tgtgaaggaa 1138981 aaactgcaaa aaattgtgac acgtgtgtcc ggcattttaa gcgagcatgc gaaagcgagc 1139041 ggattcgtac cgatcgggct tgaactgggc tttggaggaa aagggccgct tccgccgctg 1139101 acctttcaac tgaaaaacgg ctgtacgatg gaactcgtcg ggcgaattga ccgtgttgat 1139161 aaggctgaaa gctcaaaagg cctgctcctc aggattgtcg attataaatc aagcgacaaa 1139221 ggccttgact tagcggaagt atattacgga ttggcactgc aaatgctgac gtaccttgat 1139281 ttatcgatta cacattcagc tgactggctc gggatgaggg cgacgcctgc cggagtgctg 1139341 tatttccata ttcatgaccc gatgattcaa tctaatctcc cgcttgggct tgacgagatt 1139401 gaacaggaga tctttaagaa atttaaaatg aagggcttgc tcctcggtga tcaggaagtg 1139461 gttcgcctca tggatacaac ccttcaagag ggacgttcaa atatcataaa cgccggcttg 1139521 aaaaaagacg gctctctcag atcagactca gcagcagtcg gtgaaaagga atttgatctt 1139581 ttgacaaagc atgtgcgccg caccttccaa gaagcgggcg aacaaatcac cgacgggcgc 1139641 gtatccattg agccgtacaa aatgaagaac aagacgccgt gcacatactg tgcgttcaaa 1139701 tcagtatgcc aatttgatga atcactggaa gaaaacgagt atcgcccatt aaaggctgaa 1139761 aaggacaaga caatacttga gtggataaaa aaggaggcgg atggcaatga acattcctaa 1139821 accggcagac agcacatgga cagatgacca atggaatgcc attgtttcaa ccggccagga 1139881 tattcttgtg gcagcggctg cgggctctgg taaaaccgct gtgctcgttg aacgaatgat 1139941 tcggaaaatc accgcggagg aaaacccaat agatgtagac cgtcttctcg ttgtgacatt 1140001 tacaaacgcc tcagcggcag agatgaagca ccgaatcgca gaagccttgg aaaaagagct 1140061 tgtacagcgc cccggctcgc tgcatattag acgccagctg tctcttttaa accgggccag 1140121 catttcgacg ctccattcct tttgcctgca agtgctgaag aaatattact acttgatcga 1140181 tcttgatccg ggctttcgga tagctgatca gacggaaggc gagctgatcg gggatgaagt 1140241 gcttgacgag ctgtttgaag acgaatacgc aaagggcgaa aaggcgtttt ttgagcttgt 1140301 tgaccgctat acgacagacc ggcatgatct ggatctgcaa tttctcgtta aacaggtgta 1140361 cgagtattcc cgatcccatc ccaacccgga ggcgtggctg gaaagctttg ttcatttgta 1140421 tgatgtatca gaaaagagcg ccatcgagga gctgccgttt tatcaatatg tcaaagaaga 1140481 tattgcaatg gtgcttaacg gggcgaagga aaagctcttg cgcgcgcttg agctgacgaa 1140541 agcgccgggc ggcccggcgc cgcgtgctga caattttctt gatgatcttg ctcagattga 1140601 tgaactgatt cagcatcagg acgatttcag tgaactatat aagcgggtgc ccgccgtctc 1140661 ttttaagcgt gccaaagcag taaaagggga tgagttcgat ccagcgctcc ttgatgaggc 1140721 gacagatttg aggaacggcg caaaaaaact gcttgaaaag ctcaaaaccg actacttcac 1140781 gcgaagtcct gaacagcact tgaaaagcct agccgagatg aagcctgtca ttgaaacgct 1140841 cgtacagctt gtcatcagct atggaaaacg attcgaagct gcgaaacagg aaaaatcaat 1140901 catcgatttt tcggatttgg agcattactg tttagcgatt ttgacagctg agaatgacaa 1140961 aggtgaacgt gagccgagcg aggctgcaag gttttatcag gaacagtttc atgaggtgct 1141021 cgttgacgaa tatcaggata ccaacctcgt gcaggaatcg attctgcagc tcgtcacaag 1141081 cggtccggag gagactggta acctgtttat ggtaggagat gtcaaacagt cgatttatcg 1141141 attcaggctt gcggagccgc ttcttttcct ctctaaatac aaacggttta cagagagcgg 1141201 agaaggcacg gggcggaaaa tcgatttaaa taaaaatttc cgaagccggg ctgatatttt 1141261 agacagcaca aactttttat ttaaacagct gatgggcggc aaaatcggtg aggtcgatta 1141321 tgacgagcag gctgagctga agcttggtgc agcgtatccg gacaatgacg agacggaaac 1141381 agagctgctg ctgatcgaca acgcagaaga tacggatgca agcgaggaag cagaagagct 1141441 tgaaacggtg cagtttgagg caaaagccat cgctaaggaa attcgtaagc tgatttcatc 1141501 gccgtttaag gtgtatgacg gaaaaaagaa aacacatcgc aatattcaat accgagatat 1141561 cgtgattttg ctccgttcga tgccgtgggc tccgcaaatc atggaggagc tgagagcaca 1141621 gggcataccg gtttacgcca atttaacgtc aggctatttt gaagcggtcg aagtcgccgt 1141681 cgcgctttct gtgctgaagg tgattgataa tccgtatcag gatataccgc ttgcctctgt 1141741 gctgcgctca ccgattgtcg gagcagatga aaacgagctg tctttgatcc ggcttgaaaa 1141801 taaaaaagcg ccgtactatg aggcgatgaa agactacctg gctgctggtg accggagcga 1141861 tgagctttat caaaagttaa atacgtttta cggacatctg caaaaatggc gcgcgttttc 1141921 gaaaaaccac tcagtatctg agctgatttg ggaagtgtac cgcgacacca aatatatgga 1141981 ttatgtcggc ggcatgccgg gcggaaaaca gcgccaggcc aatttgcgtg ttctttatga 1142041 cagggcgcgt caatatgaat caacggcatt tcgcggcttg ttccgtttcc tgcggtttat 1142101 cgaacgcatg caggagcggg gcgatgatct tggtacggcg agagcgctca gcgagcagga 1142161 ggatgttgtc cgcttaatga cgatccacag cagcaaaggg ctcgaatttc cagtcgtgtt 1142221 tgtagcaggt ctcggccgga atttcaacat gatggatttg aacaaatcgt acctgctgga 1142281 taaggagctc ggatttggca cgaagtatat tcatccgcaa ttacgcatca gctatccgac 1142341 acttccgctc attgcgatga agaaaaaaat gcgcagggag ctgctgtcag aggaattgcg 1142401 tgtgctctat gttgcattaa cgagagcgaa ggaaaagctg tttctgattg gctcatgtaa 1142461 ggatcatcag aaacagcttg caaaatggca ggcatccgcg tcccaaactg attggcttct 1142521 gccggaattt gaccgctatc aggcgagaac gtatctagat ttcattgggc cggctcttgc 1142581 caggcacaga gacttggggg atttggctgg tgtgccagca cacgctgaca tctcaggtca 1142641 cccggctcgt tttgccgttc aaatgatcca ttcctatgat ttgcttgatg atgatctgga 1142701 agaaagaatg gaagaaaaaa gcgagcgcct agaagcgatc cgccgaggtg aaccagttcc 1142761 cggctcgttt gcgtttgatg aaaaagcccg cgagcagctg agctggacct acccgcatca 1142821 agaagtgacg caaattcgga caaagcaatc agtttctgag atcaagagaa aaagagagta 1142881 cgaggatgaa tacagcggca gggcccctgt aaaaccggct gatggaagca ttctgtacag 1142941 acgtcccgct tttatgatga aaaaaggcct gacagcggca gagaaaggga ctgccatgca 1143001 tacggttatg cagcatatcc cgctgtcaca tgtgccgtcg atagaagaag ctgagcagac 1143061 ggttcacagg ctttatgaaa aagagcttct cactgaagaa caaaaagacg ctattgatat 1143121 agaagaaatc gtgcaatttt tccatacaga aatcggcgga cagctgatcg gtgctaagtg 1143181 gaaggaccgg gaaataccat tcagcttagc gcttccggcc aaggagatct atcctgatgc 1143241 acacgaggca gatgagccgc ttttagtgca gggtattatt gactgtctct atgaaactga 1143301 ggacggatta tatctattgg attataagtc ggaccggatt gagggcaaat tccagcatgg 1143361 atttgaagga gcggccccga tcttgaagaa acgatatgaa acgcaaattc agctgtacac 1143421 gaaggcagtg gagcaaattg caaaaacaaa ggtaaaggga tgtgcgcttt atttctttga 1143481 cggagggcac attctgacat tatagcgaga tccataagct ccggaatttc aggcggagcg 1143541 ggtctcgttt tctatataaa agagaggtga aagcatttgc ggattttaca tacggctgac 1143601 tggcatcttg gaaaaacgct tgaaggaaga agcaggctga gtgaacaggc cgatgtgctg 1143661 gatgaactga atacgattgt aaaggatgag cagatcgatg ccattgtaat ggcgggggat 1143721 gcatttgaca ccgtaaaccc gccagcttta gccgagcagc tgttttatga aagcctgtct 1143781 gcgcttagcg acagaggaaa gcgcccgatc gtcgtcattg ccggaaatca cgataatcct 1143841 gaccgtttgt ccgccgcttc accgctgaca catgaaaacg gcattcattt aatcggttat 1143901 ccgacaacag agccgattca tattgaagtg ccttcagcag gagagctttt ggcggttgga 1143961 gcgctggcgt acccatctga agcgcggtta aatgaagtgc tatccgatac gtttgatgaa 1144021 aagctgctcc gtgatcacta tgatgtgaaa atcaggcagg cgtttgagca tatgacaagc 1144081 cggttccgga ccgatgcagt gaagattgcc gccagccata tttatgtggc aggcggaaac 1144141 caaaccgatt cagagcggcc gattgaagtc ggcggtgcat acacggtggc tgctgaaagc 1144201 ctgccggcag atgccgctta cgttgcgctc ggccatttgc atcgcccgca aacgatcaag 1144261 cgggcgcgga cgcttgcgcg ttattcagga tctccgctcg cctacagctt ttctgaagcg 1144321 ggctacgcta aatcagtgac gattgtggac gcaaagcctg gggaagaggc cacttggcaa 1144381 gaggtgttat tatcaagcgg caagccactt gtgaagtgga aagcggcaaa tggattaagt 1144441 gaggtgtaca gctggctgga tgaaggcaga gatcagaatg cttggattga cttggaaatc 1144501 cgtgtcgcgg accagctgtc acttgaagag attcacaggc tgcggaaggc gcacccgggc 1144561 tttatccata tcaggccggt ttttgaagaa cagaacaaag accgggaacg gatcgaggtt 1144621 aaacatgtct caatcgagga ccgctttaag aaattttatg aaaaacaaac tggcggtgcg 1144681 gtgccggatg aagaaatggt gaagctgttt ttagagcttg catcaggcgt tgaagaggag 1144741 gatgcgaaat gaagccgatc gccttaagca ttaaggggct ccacagcttt agagaggagc 1144801 agacgataga ttttgaaggc ctttccggtg ccggtgtttt cggcattttc ggcccgacag 1144861 gaagcggtaa atcctctata ctcgacgcaa tgacgcttgc tttatacgga aaggtggaac 1144921 gggcggcgaa taatacgcac ggaatcttaa atcacgccga agatacgctg tctgtgtcct 1144981 ttacctttgc gcttcagacg aatcaccaaa tctcatacaa agtcgagcgt gtgtttaaga 1145041 gaacggatga aatgaaggta aaaacggcac tttgccgctt catcgaaatc aaggacgagc 1145101 atacggtgct ggctgataaa gccagcgaag tgaataaaag agtggaggag ctcttagggc 1145161 tgacgatcga cgattttacg agagcggtgg tgctgcccca agggaaattt gctgaatttc 1145221 tgtctttaaa aggggcagag cgcaggcata tgcttcagcg tttatttaat ttggagcaat 1145281 atggagacag gcttgtgaaa aagctgagac ggcaggcgca ggaagccaat gcgagaaaaa 1145341 atgaaatgct tgctgaacag tccggtctcg gtgaggcgag ctcagaggca gtggagcagg 1145401 ctgaaaaggt tctcgaacaa gctgaagccc ggctggaagc gatgaggaag aaccgtgatc 1145461 aggcgaagga gcggtttaca gagcatcagg agatatggaa tgtccaaaag gaaaaatcca 1145521 cttatgaaga agaggaaaaa cgtctcgcag aagaacagcc gcatatagac agcatgcaaa 1145581 aacgcctgct ggaagcagaa acagcagcag cccttaagcc ctatgcggac cggtacgcag 1145641 aagcgatcca gcatgaggag caagctgaaa aggaacaaac gctagcccaa aaggatttag 1145701 cagaccggac agctttcttt cagcaaaaac atgaagagta tgaagcgtgg cgccagcata 1145761 aaagcgagaa agagcctgag cttttagcca aacaggaaca gctttcacgc ttgcaggaaa 1145821 tcgaaatcaa actgagtgag gccaagcaag aggaagagcg caaaaaggct gacctccggc 1145881 agaaagaaga ggctcttcaa tctgtcatga atgaattaga gaccgtaaca gaccgcctga 1145941 cacgagggca aaacagacag acagaattga agcagcagct caaatccctg caggtgacat 1146001 ccgatgagcg aaaaagctgc cagcaggccg cagagatggc attgcgcatc agacaaaccg 1146061 aggaacaaat caaaaaagag aaaaaacgaa gtgaagaatt gaacctcgtg ctgcagaaga 1146121 tgaatgaaga gaagaataca ctcgttcaaa agacggaagc ggaagaaaac aacatcattc 1146181 aggcatatga ggcagttcaa actgtgtacc atttggtgtg cgaaacggaa cgctcattaa 1146241 cacgtatgac ggaagaggct agaaagagtc aacacacgct tcacttacag cgtgaaaaag 1146301 caagggtggc actgctgaca aaagagttag cccaaaagct gactgccgga aagccttgcc 1146361 cggtatgcgg ttcaaccgat catgatccat ctgcctcggt acatgaaacg tatgaagccg 1146421 acagccatct tgaagaggac atcaaacgga cagatgtgtt attgacggaa gctgcagctc 1146481 tcagccagga gattctttca gccaaaatta tgcttgaaga acagtccgcg cgctttattg 1146541 aacagtgtcc gtttttgcag acaattcaag cacagaacct tgaagcggca gcttccttcg 1146601 aacatcagcc ggtgtatgaa gcatttgaaa ctgccaaatt tgaatggaaa cgaatcaagc 1146661 aggacattct ttctgttaag acacgaatgg cacaaatgat tggcgcctat caggagtctt 1146721 taaaaaaggc cgagcagctt aatgaaaaaa tcggttttga aaaaagagaa gccgaccgta 1146781 ttgaaagcat catcagtgag cttcaatcct caatggacag cagtctgaac atgtttaaag 1146841 aagcatttca gaatcaatct gtggacgaag cagaaaaatg gcagcaagcc attgaagaaa 1146901 aggaccgggc tgcagaagaa tgtgaaaaac gaattgagaa gagtatcgcg tttcttgctg 1146961 agcatgaagc acaaaaggaa aaactgcggg aatcgggaca ccggcttgag cgggaaaagc 1147021 tggagcttca ttatgcggct gaacgcatca agagcgtgat agctgattat gagcacgaac 1147081 tcggagatta tgcaaaagga gattcgattc aaatcaaact ccgctctgtc cagcaggatc 1147141 taaagctgtt aaaggaaaaa gaacaatctt tatatgaaga actgcaaagc gcccaaatga 1147201 agctcaacca agcgaaaagc cgcgcttctg caagcgagct cactcttcaa gaggcgaagg 1147261 gcagattgga aaaagcaaaa gctgcttggc ttgagcatac aaaaaacacc tccattaccc 1147321 ggactgagga ggttgaacaa agtctcatcc cagctgatga acttgaaaag atgaaaaccg 1147381 gcatagacca gtttatggat aaactgaagc aaaatgctgc aaacttaaaa cgagtagcag 1147441 agatacttgc cggcagagca ttatcagaga gcgaatggaa cgaaaccgtt gcagcattac 1147501 aagaagctga ggacgcattt ggcgctgcta tagaggaaaa aggcgcggcc gcaaaagcac 1147561 tggctgtcat tcgcgaccat cataaacggt ttaatgaaat tgaagctgaa ctgaaaaaat 1147621 ggcagatgca tatcgacagg ctggacaagc tgcaagctgt gtttaaaggc aataccttcg 1147681 tcgaattttt agctgaggag cagcttgaaa gcgttgcgag ggacgcctca gcaagactca 1147741 gtatgctgac aagacagcgc tatgccatcg aagtagattc tgagggcggc ttcgtgatgc 1147801 gggatgacgc gaatggaggc gtacgacgcc cggtttccag tttgtctgga ggagagacct 1147861 tcctcacctc gctttcactt gctcttgcgc tgtctgcgca gattcagctt cggggggaat 1147921 acccgctgca gttctttttc ttagatgaag gcttcggcac actggatcaa gatctgcttg 1147981 atacggttgt aacggccttg gaaaaacttc agtcagacaa cctggctgtc ggtgtcatca 1148041 gccatgtgca ggaactgcgt gcacggcttc cgaaaaagct gatcgtccat ccggctgaac 1148101 cgagcggccg cggtacgcgg gtatcacttg agttgatgta agggaggagc ggatatggca 1148161 aagcagattg ccggaatatg tgagctgtgc ggccggagcg atgtccagct gacagagcat 1148221 catcttacac cgaaagagga aggcggaacg tttttgccga cagcgatgct ctgtattcct 1148281 tgtcataaac agattcatgc cttatatacc aatcaagagc tcgctgtacg tttaaatgga 1148341 atggctgaac tcagaagcga tccagagctt gcccggtttg tcaaatggat cagaaaacag 1148401 ccgcctgaga agctgatcaa aactaagaaa tcaaatgaac gaaaaaagaa aaaatgacta 1148461 aaaagcagcc ctctctttgc agagcggctg cttttatccg tttccaacca tatcctgatc 1148521 gttgacatcg gggtctatat aatttgtcgc gttgactgca ttatttaata gaaggaaatc 1148581 tcccgtgttt cctgctcccg aaccgagcgc agattttgaa gagcttttcg gagaaaggta 1148641 aaaggaatca ccaaagttta cgactccgcc cgatatggaa ttgatagcta taggcccgac 1148701 aattgctggc ataaacgaca ccctttatcg aagtctctgt ttattatatg ttcttggcgg 1148761 gcgattgtga gcgcggagac tgaatctgtc tgatatgttt gagtctcgca tcaccgcgaa 1148821 taagcgaagc tgatccggca tgtaaaacag aagaggctga gaccccttga attttgatgc 1148881 tgcgaacata aatagccggc acctcgtggc aaaacgcgct ttgtacacct gtttcgggga 1148941 gcggcttcac ggcctgctgc tgaaagatct gatactcctt tttgttaaat gagccttcat 1149001 tatggtaaaa cgtggacaga gaacgctgca cagcaaatac ttttacactc atatcgattt 1149061 catttgtgtc gccaacttga aacacacttg cgatcccgag agaattaaac ttaactagtc 1149121 tgatgcgcga tatgcgttta agcattattc tggcgcaagc ggagcaaacg gcccaataat 1149181 aagagattca ggcggtgtat caaaaataga agacaggtag atggattcag tgtctccgat 1149241 gtggaaaacg gaggaactgg acacaccgtt catccgaata tccccgactt ccaagctgcg 1149301 gttgatgact gtaaagatca tgcttgctca tctcctttca tttctgatgg aatatgctcc 1149361 agaaagtgtt ctacagcgcg gatgacatca cgcttcacat gctcagcgat atgttctgca 1149421 tattgtgcag gcggtgtatt ttcttctttt ttgatatggg acatataata gtgaatcctg 1149481 ctgtccattt gttttctgat gtcttcaata acatgatgtc tgtttgtatc gtcaagtctg 1149541 ctgtcatatt gattttcaag ctgttccaaa atatctggga tttcctcggt taagtacatg 1149601 tcgacattct ggcggatctg ctgcatgagc tgagcgctct cttcctgctg catcatcccg 1149661 atttgcggtg tcgactggct gacgtcaaag ttttggacgc tgttcgggtc agtcggattt 1149721 aaaccgatat tcaaagtccc gtcgagcctt tcgattttca gctgatcaaa tttatactcc 1149781 acacgctcaa tggtagtggc cggccgctgt ttcatcgtat tcatttcagt ttgaatctct 1149841 ttcagctgac gttcgagctg ctgaatgtga atcgcctgct gctgaacgaa ggaattcaag 1149901 ttttgcaggt aagaggaaac agattgatca tacatgttct tcacctcttt catatgatta 1149961 acggccagga ggctggagcg ggaccaatga acctgtgtcg ggctcctgca gctggagcgg 1150021 ttgccctgag ccagaaactt ctggtgccgg ctctacatag cttcctgtat tatacaaatt 1150081 tgacagtgac ttgattgatc cggcgctccc gatttgcaga atggaggagt tgctgattga 1150141 ttccagccgg agatagttga tttgaatggt ttgattaata tagaagttca tgagcctcac 1150201 tccttttacg cattggccac gatcggctga tcaaccgcat cattgtcata cacattcgtc 1150261 gcgttttgat aattcatcac cttgaggctg tcgccggtat taaagctgcc agcaccggca 1150321 aacgttctga cctgagcctg aggagaaatc gtaatgcagt ccccgatgtg aacgactccg 1150381 ctcgtaccaa tcgcattaat tttaaacgct ccgacaatgg ccggcatacg agcacatcct 1150441 ttgttgaaaa attaaaaaaa gacaggtaaa gtgaaatgac aattccgatt tcaattgggc 1150501 tattcacgat agcttatgac aaacgcacat atgtgtgaga gaaattttaa ggggacatat 1150561 cggctctttg tgaaagcgtt ttattttttc gggccgttat gtttaaacat ggcaaaagag 1150621 gatgttgggt ataaattgag cggaaatgcg gcgaaggatg ccgctatccg cctatggtga 1150681 tttttgttta tttctttggt gtttttgcgt gtagaatgct ttttggagta tgtcgtgctg 1150741 cggtattcga tttttgggcg ggcacattct cgccctgagg tatatctcag aagtgctgag 1150801 caaaaatcgg agttaaatgt ggtgtattct aattgttata gaaaatgatt tacatacggg 1150861 agttttcaag atatctccca aaaatcattt cttctttaat ccgggtattc agcaggatat 1150921 ccagctcttg gctgcattga atcgtttctt ttgaattcat gccgtatttt tgtgcggttt 1150981 caattagtgt gatcctcatt tcttcaattt tactgttcat tacgctatct ccaattctag 1151041 attttatttt gatataaata caggatatcg ttagtataac ctattttggc tcaaaaggtt 1151101 gcctttcgtc aatttgacta aaaaagcgac aatttttgct gcggcctttt ttaatggaga 1151161 aaggactaaa gtcttgctaa gtgtgcttgc aaaaagtcct gccgttcctc aatttctcta 1151221 agtatgttgg tctgctcctt ttcgatttga aaggggcttt ttttgataaa aggatcatca 1151281 gcagcacttt gacaaatgtc aaggtgccat tcgttgatga gaggagataa tcgttcaata 1151341 gtaaacgacc gcttcagcac gtttttcatt aaggtgtgat attgcgacct gaaggcggga 1151401 atggatagaa gccttgacga aagcgtcttt ccttttgtca gaagcgggtc ttcttcatac 1151461 cattcttgta cggcaagcga tcttgtctcc atcggggaaa cgtaaagccg accggattcg 1151521 tttaaacaaa atgtgtagta aaagccttga ttggtgcagg tgttgccgat cagccacaaa 1151581 aaaaacagct tgacatccag atacaattta atcctttcag ccaattcgtc atctccggct 1151641 gtgcggatca gtatgaaaaa ttcatgtaag aatgccgagg aatcattgtt aaaaagggac 1151701 aatggaaccc ttggatcggc cgtcttcact ccgtaactcc ttttaccggc tggctgatgg 1151761 ttcttgatgt tcaaataaat gccttcaggc tggccattga tggtcagaaa gctgtacgag 1151821 gcaacgggag caggtacgcc gatctggtca aaaaaacaat aggcgagtct gcgccgcatc 1151881 agggacggat catcctgttc tgcattcaaa aaaagtgtcc tttcaccaag cagagacttt 1151941 tcccagctga tttcatagga tgccttttcc gctctgtcac gctgtgtgag aagaatggga 1152001 gaaacagatc gatctgttac gaaaagcccc ttggctgtac ctttcctttt cagctgctcc 1152061 cgatgaaaaa ataaatgcac gcgctccata ttctttcctc cttctcaaaa cgacatttgt 1152121 atgatatgta gagcaagccc gtcctgaaac gaaatgaaaa cggaattgag aaaaagggat 1152181 ttcagcattc gacagagaat acatgaagga gcattctgat ttaaaagatg atggaggaat 1152241 aacatgaaat ttgcgacagg ggaactttac aaccgaatgt ttgtcggcct gatcattgac 1152301 gatgagaaaa ttatggattt gcagaaggct gaaaaaaaac tgtttgaact tgagacgatt 1152361 ccgggatcgc tgattgaatg tatcgcagaa ggggataaat tcgttgcgca tgcaaggcag 1152421 ctggccgagt gggcaaagaa accgaatgat gagctgggat catttatgta ttcattatct 1152481 gaggtgaagc tccatgcacc cattccgaag ccatcaaaaa atatcatctg catcggcaaa 1152541 aactaccggg atcacgcgat tgaaatgggg agcgaggctg atattccgga gcatccgatg 1152601 gtatttacaa aatcgccggt aacggttacg gggcatggtg atatcgtaaa gagccatgaa 1152661 gaggttacct ctcagcttga ttatgaggga gaacttgctg tcgtgatcgg aaaaagcggg 1152721 actcgcattt caaaagaaga tgcatatgac catgttttcg gatatacgat tgtgaatgat 1152781 atcacggcgc gtgatctgca aaaaaggcat aagcagtttt ttatcggaaa aagcttggat 1152841 acgacatgtc cgatggggcc cgtgcttgta cataaatcat ctattcagga gccagagcgc 1152901 ctcaaggttg aaacaagagt caacggcgag ctgcgccaat ccggttcggc aagcgatatg 1152961 atcttttcca ttccggaatt aattgaaacc ctctcaaagg ggatgacgct tgaagcgggc 1153021 gacattattg ccaccggtac gccgtctggt gtcggcaagg ggtttacgcc tccaaaattc 1153081 ttgcggtcag gtgacaaaat tgatattaca attgatccga tcggaacgct gtcaaaccaa 1153141 attggctgaa taaaactgga gggcggaccc ggacccgccc gttttttctg ataatcatct 1153201 ttgtgacaga ggacaagttc atggtactat aagtggggta atttatctga tagggggaac 1153261 atatatgaca cacctacata ttacgacatg ggtggtagcg ctgattctgc ttttcgtcag 1153321 ctactcgctg tattcgtcag gaagtgcaaa gggcgcaaaa atcactcata tgattctgcg 1153381 gttattctat atccttatta ttttgacagg agctgagctg tttgtccgtt tcgccaactg 1153441 gaacggagaa tacgccggca aaatgattct gggcattatc accatcggcc tgatggaaat 1153501 gctcctcatc cgcaagaaaa aagaaaaatc aacaggaggc ctgtgggtcg gcttcgtcat 1153561 tgtccttttg ctgacagtgc tgctcggtct gcatttgcca attggttttc aattgtttta 1153621 atagaaaaac ctatgaaccc ggctctttga tagagctggt tttttttata tttatcccct 1153681 catattccaa atcatttaaa ataaccttaa aattccctgt aagcggtatc tcgtcctatg 1153741 aaattatgat accttcaagg agattcatta ttttgcagga gggataacat gaaacgcaga 1153801 aaattcagct cggttgtggc ggcagtgctt atttttgcac tgattttcag ccttttttct 1153861 ccgggaacca aagctgcagc ggccggcgcg atcgatcagg cggctgctct ggaaaacggc 1153921 aaagagcaga caggcgccat gaaggagccg gaacaggtga aatggtacaa agtgaccccg 1153981 ggagcaacgg atattcagaa aaactcacat atggcactga ccgtaaagag tgattcagta 1154041 ctgaatgtat ctgtatatcc aagtaaggaa aaagcgctta aagatgagac gtttgagatg 1154101 taccgttctt tcacagcgga ggatggaaaa agcgaagtca tttttccata cgcgtggagc 1154161 ggcccttact atgtaaaagt tgaatacctc ggagaagaag aaccagagga cggcggaacg 1154221 gcagaagcag ctgcagaagc caagtatacg attgggtata aaggcaccaa aaaacagccg 1154281 tcagatttag aagaggaaga agcttgtccg gttgaaatga gtgtcgatca gaagaaatca 1154341 ggaaaaggca tcctggataa gttgagatcg attcgtgatg agcagctgag ccaaacagca 1154401 gaaggcaaag aactgacaag cctttattac aaagcagcac cgtttatcgt tgcaaagctc 1154461 gcactcaata aaacagcaag aaatgaaatc tatcaggatc ttgtgacatt aaagccgtta 1154521 tttgacgatg tgtcagaaaa cggagcatca tcttcgtata aggtcactga aaaggatcaa 1154581 aaagcgatca accggctata tgataaagct ttacaatcag tcccgtcatt ccttaaagag 1154641 gagataaaga aacaagcgga ccgactaaat atgaagcagc tgcaaggcaa aacagcagga 1154701 gccattttaa cagaaaacaa tattgcagca aaaagtgaag ttcagacaac aaaggttatt 1154761 ttcaaggtga aggacaataa aagcctctca tccgtacata atgaaatgaa gggcttttct 1154821 gcaagcgcgc aatcgaaaaa agacatatct aatgtgaaaa aggcaaagaa actgtttgac 1154881 aatctgtatt catttgaact tccgaaagac gagaaacaga acggcgcata tacggcaagc 1154941 gccaaaaggg tcaaaagcgc tgctgcgaca ctatccaaga tgtccaatgt agagtttgcg 1155001 gaacccgtac aggaatacaa aagcttggca aacgatattc agtaccctta tcaatggccg 1155061 cttaaaaaca acggtgaaaa cggcggtgtc aaaaatgcgg atgtgaaata tgagcctgcc 1155121 aacacattgc tgtccaaacg caagcttaac gatacactca ttgcagtagt agacacaggc 1155181 gtagacagca cgcttgccga tttaaaagga aaagtaagaa cagatctcgg acacaatttt 1155241 gtcggacgaa ataacaatgc aatggatgat caggggcatg ggacgcatgt cgcaggcatt 1155301 attgcagccc aaagcgataa cggctattca atgactggat tgaatgccaa agcaaaaatc 1155361 atccctgtaa aagtgcttga ttccgcaggt tccggagata ctgaacaaat tgctctcggc 1155421 atcaaatatg ctgctgacaa aggagcaaag gtgattaatt taagtttagg cggaggctac 1155481 agccgcgtgc ttgaatttgc tttgaagtac gcagctgaca aaaatgtctt gattgccgca 1155541 gccagcggga atgatggaga aaatgcctta tcttatcctg catcttctaa atatgtgatg 1155601 tcagtcggcg caacgaatcg catggatatg accgctgatt tctctaacta tggaaaaggt 1155661 ctggacatct ctgctccagg gtctgatatc ccgagcttag tgccgaacgg aaatgtcacg 1155721 tacatgagcg gaacgtctat ggcgacgcca tatgctgccg ccgctgcggg actgctgttt 1155781 gctcaaaatc ctaagctaaa aagaacagaa gttgaggata tgttgaaaaa gacggcagat 1155841 gatatttcct ttgaaagtgt cgatggcgga gaagaagagt tgtatgacga ttatggcgat 1155901 ccgattgaaa ttccgaagac acctggtgta gactggcatt caggctacgg gcggctgaat 1155961 gtcatgaagg ctgtcagcgc agctgattta cagcttaagg tcaacaagct ggaaagcact 1156021 caaacagctg tcagaggaag cgcgaaggaa ggcaccctta tcgaggtgat gaacggcaaa 1156081 aagaaactcg gcagcgccaa agccggaaaa gacaatgcgt tcaaggtgaa tatcgcgact 1156141 caaaaacagg atcaagtact gtatctgaaa gcaacaaaag gcgatgcgaa aacatcgtat 1156201 aaagttgttg tcgtcaaagg aaaaccttcc ggcacaccga aagtaaacgc ggtgaaaacg 1156261 aaggatacgg cagtaaaagg gaaggcaaac agcaaagcga tgatcagagt gaaaaacaaa 1156321 tcaaagaaag tcattgcttc tgccaaagct gacgcaaaag gaacgttttc ggtgaaaatc 1156381 aaaaaacaaa aagccggaac ggtgctgtac gtcacggctg tggatacaga taaaaaagaa 1156441 agcaaggaag caaaagttgt tgttgaaaag taaccaaaaa gcggtgctcg atgcaccgct 1156501 tttttatttg cgcccccgtt ggactgctgt gtacataatg gatcgctttc cgtttgaagc 1156561 cgtccattca aaacggtctc ctgtcccttc gctgctgtag ttgtagtgat gctgcatcgc 1156621 gcattgtgcg gtgtcatttg aaaagtgata aaaggacaca ccctgccccg ccgaagtatt 1156681 cgaaaagact cctttattat aagaaaagac gcaatcgaat accgataagc cgaagctgtg 1156741 caagtgctgc agaaatgcga gaaaggtttc gtcgtcaagc gaatccaaaa gcgccatgag 1156801 cggccgcttg actgatttct catagcggat gcgttctccg ccggaaaggg agatgttttc 1156861 tgcaccgcat gccaaaacca acttgtcctg aaagccggct tgctcccact ttcctttatg 1156921 atggatccag attgggctgt gttggagact gtccgccagc agtatatcgc cttcaccgtt 1156981 ttcgattaag cagatgccgt cttcaatgag gatggtgccg tattcccact ttcgttcctc 1157041 tgtatataac aattgtttcc gtttcatcca tgctgtctcc tttttcttca ttcctctctt 1157101 ttctttccaa ttcaagcctg tcccatacaa ctcttttatg gacaaatcaa ctatctgcct 1157161 atagatgcat aaacttacta aggtgctgaa agaaacgaaa ttgttacgaa agaaacggga 1157221 ttggagctga tgtcacatgt gtggaattac gggttgggtc gattttaaaa agcagctcgt 1157281 ccaggaaaaa caaacgatgg acagaatgac agacactctt tccaaacgag ggcctgatga 1157341 ttcaaacgtt tggggggagc accatgtttt attcggacat aaaagacttg cggttgttga 1157401 tattgaaggc ggacgccagc cgatggcgtg tacctataaa ggcgatacgt acaccattat 1157461 ttacaatggc gagctttata acacggaaga tttgcgcaaa gaattgcggg cgcggggcca 1157521 tcaattcgag cgtacgtcag ataccgaggt gcttctgcac agctacatcg agtggcagga 1157581 agactgtgtc gaccatctca atggcatatt cgctttcgct gtgtgggatg aaaagcgtaa 1157641 tctgttgttt gccgcgagag accgtctcgg tgtaaagccg tttttttaca cgaaggaagg 1157701 ctcttcattt ctcttcgggt cggaaatcaa agcaatcctc gcgcaccctg atataaaagc 1157761 gcgagtggac agaacgggac tttctgaaat tttcggtctt ggaccgtcca gaaccccggg 1157821 cactggcata tttaaaggca taaaagaaat ccgcccggct cacgcgctga cattttccaa 1157881 agacggactt aatatttggc gttattggaa tgttgaaagc gaaaaacata cggacagttt 1157941 tgatgacacg gttgccaatg tcagatcgtt atttcaggac gcggtgacgc ggcagcttgt 1158001 gtcggatgtg cctgtttgca cattcctatc aggcggtctg gactcaagcg cgattacagc 1158061 gattgcggcg ggccattttg aaaaggaagg aaaagcaccg cttcatactt attcgattga 1158121 ttacgaagag aacgataaat attttcaagc aagcgctttt cagccgaatg atgacggacc 1158181 atggattgaa aaaatgacag aggctttcgg cacaacgcac cacaaatgcg tcatcagcca 1158241 aaaagacctc gttgatcatt tggaggaagc tgtactggtc aaagacttgc cgggaatggc 1158301 agatgtcgac tcatccctgc tgtggttttg ccgggaaatc aaaaaggact ttgtcgtcag 1158361 cctatcggga gaatgcgcgg atgagatttt cggcgggtac ccgtggttcc atacggcaga 1158421 tgttgagtct ggctttccat ggatgagatc aacggaggag cggatcaagc tgctttctga 1158481 ctcatggcag aaaaaattga atctgaaaga atacgtaaat gccaaatatg aagaaacctt 1158541 ggcagaaacg ccattattag acggagaaac gggtgtggat aaagcaagaa gacagctgtt 1158601 ctatttaaat atgctttggt ttatgacgaa ccttttggat cggaaggatc gcatgagcat 1158661 gggggcgagc ctggaagtgc gggtgccgtt cgccgatcac cggcttgtgg aatatgtttg 1158721 gaatattccg tgggaaatga aaatgcatga taatcgggaa aaaggcattt tgcgcaaagc 1158781 gcttgagggc attttgcctg atgacatttt gtatcgcaaa aaaagcccat atccgaaaac 1158841 acatcatccg gaatatacaa aaggcgtcag cgagtggctg aaaacgatca gaagccaaaa 1158901 ggactccgtg ctccatacct tactggacag aaaacaatta gatcagcttt tagaaacgga 1158961 aggctcctcc ttcaaggtcc cgtggttcgg gcagctcatg aaggggcctc agctgatcgc 1159021 ccatcttgct caaattcata catggtttga agcgtatcgc attgatattg acgagaggta 1159081 ggttcaatac aaatgtgatt aaaagccaga gatgtataga tttaaataag aaggatagat 1159141 gagcagggaa atatatgctc tatctatcct tttttgtaca acagcactat cgaattgccc 1159201 ccgcattcct tcaataagaa tgaataggtt ttaatgttct gccgataaaa ctagctgata 1159261 ccgggcttaa ctttaattcc ctagcccata cagaaagttg accaatatgg tgaatttcgt 1159321 gagcgatgat atggtgtaat atttcatctc gcgtatataa aacacctgtc tcccaaggaa 1159381 cgcttacaag ttcatctttt atttgatctg aatgtgtttg taaaacatca attatttcag 1159441 ttcggaatgt atttgagaga gatttcactt tattgagtgt ttgataatca gcgaactgaa 1159501 cagcgatatc ttcttttcct tggatagcac gaatccaact atattccaca tcaataatat 1159561 gaaaaagggt atataaaata ttctctactc cgccaagacg atttttaagt aattcttcag 1159621 tggttagttg atgacaccaa gtaaaccatt gatctctaac ctgccagtta tattcaaaaa 1159681 atttcatcac taaactcact ccaatactat catgtatcat aacaattagc ccttttttcc 1159741 gtgattcctc tattaatgaa gtgatgattg agaaatgttt acattctacc tgttgtatgg 1159801 cattaaaaat aataatgcat atctcgtcga tgatgctgtg cgtcttgtta cttttacaaa 1159861 gtaagaatcg gcattttctt catatacaat taggaaaaaa catactagac ttgaagaagc 1159921 agtgatacat aggagtgaga aaatgaaaga gataaaagaa gcttaccagc aatgcggaca 1159981 gattgttggc gaatacgcgc cagcctgttt caaagcatta tcatatctcc cgctaaagca 1160041 aagacaagcc tcttgggcag tattgtcgtt ttgccacacg gcggccagtg cagacgaaaa 1160101 ggtattgccc gcatttgaag ctaaagctga tcatgtttac caaaggacaa ataacggtaa 1160161 acaacatcta tggaaggctt ttgatcatgc gtatcggacc tttacattgg aaagcgaacc 1160221 ttttcgggag tttattgccg cacaaaaaga agacgccaag ccgtatgatg accttgatga 1160281 actgctcatg tacgcatatc ggacgggcgg tgctgccgga ttgatgctgc tgccgatact 1160341 gacacgccga aaacaagatc agctcaaaca agcagccgtc tctctcggct tggccataca 1160401 gctggttcgc ttcttaagtg atcttggcac agatcagcaa aaaaaccgca ttccccgtca 1160461 ggtaatgcag caattcggct atacagaggc tgatctccaa aaaggcaccg taaataaagc 1160521 gttcacaatg acgtgggagt atatcgcttt tgaagcagaa gcctaccttg aagagtgtca 1160581 ggatgccttg ccgctatttc cgcagtattc tcaaaaaacg gtgaaagccg ctcttcattt 1160641 gcaccgggct gttttagaaa aaatccgggc gaagcagcac gatgtatttc aatatcactt 1160701 cgctctcaca gagaccgaag tgaagcagat tctgtctgat atctaaaaaa cacccggcct 1160761 tgattgagcc gggtgttacg ccataccttt ttgaatccag atacgtgagc gccatcttct 1160821 gtacattaag attccccgga cccattcatc cgcgataaaa gaaatccaaa tgccggcaag 1160881 accgaaaccg aggtggatgc cgaaaagata agcaagcggg aggccaatgc cccacattga 1160941 aatcattgcc atgtaaaccg ggaatttcgc atcccccgcg gcccgcagag agttaatgat 1161001 aatgacatta aacgagcggc ctggttcaag gataatggtc atggcaatca ataggcttgc 1161061 agttgctata atgtcagggc tttgtgtgaa gagtccgatc aggtcttttg aaaagatcgt 1161121 catcaaaaca gaggtagccg cagcaattcc gagtgcccaa tataagctct tcatgcagcg 1161181 ctcataagcg gcatcaaatt gtttgccgcc gatataacgg ccgattaaga tttgtgtacc 1161241 ctggctgatc gcagtgccga acagcaaaat aaacatcgta atattttgcg tatacacttt 1161301 tgttgtcaac gcctgcgcgc ccatgatggc gataaaatac gtgactatca tttgcgacag 1161361 gttgtatgaa agctgctctc ccgcagaagg aatgccgatt ttcagcagct tgcgcaaatg 1161421 ctctttatgc atatgaaaga cttttttcag cgacatcttc agctggatgc gtttgttgac 1161481 aatcacaatc atcgcgatta atccgatgac gcgggcgata gatgtggaca tggccacacc 1161541 ggcaacaccg agaacaggaa agccgaacaa accgaaaatc acaacaaagt ttccggcaat 1161601 gtttaaaatg ttcatgccga tagtgacaaa cattgtatct tttgtgtagc cgtagctttt 1161661 taagatcgcg ctgaatgtca tgattaaagc ctgaataaag gacagacctc cgacaacttg 1161721 taaaaagact ttcgcatcag gcatcagtgc gtctgataat cccatcatat gaagcagagg 1161781 gacagccgcg aaaaagacga cggcgctgat ggccaggctg atgaagaagt tggcgccgat 1161841 tgacacataa gcgacttcca tggcttcttt cttttgccgt gagcctagaa attgtgaaat 1161901 gataacggtc gttcctgttg cgataaagct gaacatcacg ataattaaat ttaaaatctg 1161961 gttgctgacg ccgactgctg ccacgctgtt atccgagtat tggctgagca tcagtgtatc 1162021 ggcattaccc ataaacatat ataatgagac ctcaataaag atcggccaag taagcgaaaa 1162081 taatgagaac gttttgtcag cgggtttttt caaagcagtt gatttgaaga cagcttgttt 1162141 catcgtgtct aacccctttc gtaaataaaa tcaacgtttt aaagtgtacc tccatttcct 1162201 tataataaaa agggatagaa acgatacttc ttgtaaaaat ccgacttaaa aaggaggatg 1162261 attcaaatgc ctcgcatcct gtttacagtc ccgccttttc cggtatttat cgcagctggg 1162321 gaaggggttt ttaaaaaagg agaaacccat gtgaaacgtg tattctccgt gtttgatctg 1162381 atatatgtca aacagggaac gttatatata acggaaaatg aaacatcgtt ttctgttgaa 1162441 ggcggcgagt acatcttgct ttctcccggt cttgaacact acgggacgaa gggcagtgat 1162501 gaagcaacct cctactattg gcttcacttc gatgaacatc gatatgaatt tacggcaaag 1162561 ggaggcagca actggtctga gcttcagcag gaaaaaggga gcttcgaaga gctggcccgc 1162621 tacggattgg ccttgccgag aaaaggcaag gtgcagcgcc cgcagtttat ggcgcagcag 1162681 tttgaaaagc tgatcgatta ctccgcggaa aactctgatt tgccgctcag aaagcaaatt 1162741 ttatttgagg agctgatgct gcatcttcaa aaagaagcgt tccaaatacc gtctgcgaaa 1162801 gagcgggtag cctgggaggc ggcccggtat ttacaggagc actataagga aaagacgaca 1162861 atcaaggatc tgtcgctcgc ccttcactat catcaggatt atgtgagccg ctgcatgcag 1162921 caggtgctcg gcgtaactcc ggcacaatac acgaaccggg tgagaatgac ggaagcgaag 1162981 cgtcttttat cctctacaaa tgataaaatg ggcgttattg cggaaacggt cggaatggaa 1163041 gatccgacat acttttcaaa actctttaag cagatagaag gcatttcacc aattgaatac 1163101 cggaaaattg tcagccggaa agttcaataa ccagacgagg gatgaacatg aaaacaacaa 1163161 tttacgatgt ggcaaaggcg gcgggtgttt cgatcacaac tgtgtcccgt gtgataaaca 1163221 atacggggag aatcagcgat aaaacacggc agaaggtcat gaatgtcatg aatgaaatgg 1163281 catacacgcc caatgtccac gccgcggcgt taacgggaaa acgaacgaat atgatcgctc 1163341 tcgtggcgcc tgatatttca aatccgtttt acggcgaact ggccaaaagc attgaggaaa 1163401 gagcggatga gctcggtttt caaatgttga tttgcagcac cgattacgat ccgaaaaaag 1163461 aaacaaagta tttttctgtg ctgaaacaga aaaaggtgga tggcattatt tttgcaacag 1163521 ggattgaaag ccatgacagt atgtctgctt tggaggaaat cgccagtgaa caaattccga 1163581 ttgccatgat ttctcaggat aagccgcttc ttccgatgga tattgttgtg atagacgacg 1163641 ttcgtggcgg atatgaggct gccaagcatc ttctgtcact cggccacacg aacatcgcct 1163701 gcattatcgg agacgggtca acgacaggcg aaaaaaatag aatcaaaggc ttccgtcagg 1163761 cgatggagga agcgggcgtg cccattgatg aatcacttat catccagacg cggttttcct 1163821 tggaaagcgg caaggaagaa gcgggaaaat tgctcgacag aaatgctccg actgctattt 1163881 ttgccttcaa cgacgtattg gcttgtgccg ccatacaagc tgcgagaata agaggcataa 1163941 aagtgccgga tgatctttct atcattggtt ttgataatac gatactcgca gaaatggcgg 1164001 ctccgcccct gacaaccgta gcccagccga taaaagagat ggggcggagc gtcatcgaac 1164061 tgctggcaga agcaatagag ggaaaacgaa aggcgaaaca aaaaatagtg ctcccgcctg 1164121 agcttgtagt cagacattct acatcaccgc tcaacacatg agcccgctaa tgagcgggtt 1164181 ttttcattat gacagttgaa gccaaaaaaa catattgcgt gtaaaccaaa ggcggtgtaa 1164241 aatataacca tcttttgaga aagcgcttgc gcaaaatggc agagcggata gaaccgctgt 1164301 ttttttagct gttaagagaa aacgctttct caaagcgagc ccgaaatgag ataaaggaga 1164361 ggatgggacg tggaacatca agtaagatgt gcagtattgg gattaggaag gctcggttat 1164421 tatcatgcga aaaatctcgt caccagtgtg ccgggggcaa agctggtttg tgtcggtgat 1164481 ccgttaaaag ggagagcgga gcaggttgcc agagaactcg gtatcgaaaa atggtcagag 1164541 gacccgtatg aagtgttaga agatcccggc attgatgctg tcattatcgt aacgccgaca 1164601 agcacacatg gtgatatgat catcaaagca gccgagaacg gcaaacagat ctttgttgaa 1164661 aaaccgctga cattaagcct tgaggaatca aaagcagctt ctgaaaaagt taaggagaca 1164721 ggtgtcatct gccaagtcgg ctttatgaga cggttcgatc ccgcatacgc agatgccaaa 1164781 cggcggatcg acgctggaga aatcggcaaa cctatctatt ataaaggctt tacgcgcgac 1164841 caaggcgcgc ctcccgcaga atttatcaaa cacagcggtg gaatttttat cgactgttcc 1164901 atccatgact atgatattgc ccgttatttg ctaggggcgg aaatcacttc tgtttcagga 1164961 cacggcagga ttctgaacaa tccgtttatg gagcagtatg gcgatgtgga tcaggcgctg 1165021 acgtatattg aatttgactc gggcgcagcg ggggacgtcg aggcaagcag aacctctcca 1165081 tacggacatg acatccgggc ggaggtgatc gggacagagg gcagtatttt catagggaca 1165141 ttgagacatc aacatgtgac catcctatcg gctaaaggga gcagttttga tatcattcca 1165201 gactttcaaa ctcgttttca tgaagcctac tgcttggagc ttcagcattt cgccgagtgt 1165261 gtccggaatg gaaaaacacc gattgtgact gatattgatg cgacgatcaa tttagaagtg 1165321 ggtatcgccg caaccaattc ctttcgaaac ggcatgccgg tacagctaga tgtgaagcgc 1165381 gcttatacag gtatgtaaaa gctaagtatg ttgcatttga ggctttccgc aaaaaaagca 1165441 agggcatttt agcccttgct ttctcttttc tcatataaat agtacatata atcagtaggt 1165501 acgcctgaat ggtccagctg tctcagcatg gcggttacgt tccctctgtg gtaagtgccg 1165561 tgattgacga catgcaggat ggtgtctgca taggttgatt ccagtgtacc tagtttcgga 1165621 tgctgcattg tgaaggtctg ttctaagtcc gtctggcggc tgaagaaatc atgatactgt 1165681 gactccagct cggcagcgtg ctgtttaatc gctgccatat taccttgcgc ggactgtaat 1165741 ttgcctgcgc tgtctataat ctcttggtag gccactcccg aaagaacatt cagccaaatg 1165801 tagtcagccc tgcacatatg aagcagcacg tcgctgacag aaggaaatac gctctttact 1165861 tcttgatagg cagtttcctc cggcaggttt tcgatatggg taaatatttt cttgtttgcc 1165921 caagaatgat agtcataaaa ctgttttgca tcagtcatca gcatgccccc ttttctaaga 1165981 aattcgtttt tttcatctgt ttctccttca attgcaaaag agtgacaccc caaaatatcc 1166041 tgccgctgcc cacattaccg ctgcagagca tttgtttacg atcagcataa gcctgccgct 1166101 cgtatctatc gtctgaaaca accggcccgc tattgcaagg ctgatgaacc aaatccaaga 1166161 cacagcgatg caggcggcca taaagagcca tttctcaagc cccgaatatt gaagagagct 1166221 cgtgccgatg acgccgatcg tgtccagaat ggcatgcggg tttaaaagag aaacagcggc 1166281 cgcaaacgca gcttgctttt ttggtgtgaa cgtatgtttc tcattttggc ttgtgttcgg 1166341 acggatgttc caagtcaccc agcccatata aagcaaaaat aaaaatccgc cggccatcat 1166401 gactgtctca aacacaggca gctcctgcac aatgacagac acgcccgcaa cggctaatac 1166461 aattaacaag gtatcgcaga ctgaagcact gatgacagct gggagagccc gccaaatatg 1166521 cttttgcaac gcgccttgct gaaaaataaa cacattctgc actcccagcg gcaaaattaa 1166581 gccaaacgcg agcacaattc cgtgaatgat tgcattcatg ctgaaaaagc tcctttcaca 1166641 ttttttttca atcataagag agattgtcac taaagtctcc agccatttgg ttgggttagg 1166701 aaccagccaa atgtataatg tgtaaaaaag gggggcatga ccttgtcgca atggcagcca 1166761 agccgaaagt cggatgttcc gctgcatcgg cagatcgaac aatatatgaa agacaagatt 1166821 cttcacggag agtgggctgt agggacgaaa atcccctcac agagaacgct ggccgacatg 1166881 tttcaagtca accgcagcac agtcacagca gccatagatg aactcacgtc tcaaggcttg 1166941 ttagagggaa gaaaaggcgg cggtacgaag gttgtaaaca gtacttggag cgtgctgacg 1167001 gctgagcctc cgcttgattg gagcgattac gtccgttcgg gcattcatcg cgccaattct 1167061 tccatcattc aagctattaa tcagaacgaa ccaagagcgg atatcatcag attaggaact 1167121 ggagaacttt caccggatct tgtgcctgct gacacaattg gacggatgtt tcagcaaatc 1167181 aatccgggcg tcctgtcttt aggatatgag cagccgaaag gaaaccgtca gctgcgggag 1167241 gcagtggccg accatttaaa aggaaagaag atccatgtgt caccgtctgc aattttaatt 1167301 gtgtccggtg cacttcaggc acttcagctc atctcaattg gacttttaaa acgagattct 1167361 gtcattttga cggagaagcc gtcctacctt caatccttgc atgtatttca atcagctggg 1167421 atgcggcttc gcggcttgcc gatggatgat gaaggggtca aagcggggct tgtttcttct 1167481 aatcgaaaac aatatggagg acagctgctt tacacgattc cgtcgtttca taatccgaca 1167541 ggcacagtca tgtcagagca gcgaaggaaa gagatcatca gcctgtcaaa aaaagagcag 1167601 atgcccatca ttgaggatga tgcgtacggt gatttatggt ttgaagaaaa accgccgcag 1167661 ccgttgaaag caatggatca tgagggcaat attctgtatc tgggcgcgtt ttcaaaaacg 1167721 gttagccccg gtctgcgaat cggctggctt gccggtccgg agccggttat tgaaaggctg 1167781 gcggacatta aaatgcagac agactacgga tcaagcggcc tgtcccagtg ggcggctgcc 1167841 gagtggctgt cacagggata ttatgaagag catctgactt gggtacgcag gaagcttaaa 1167901 gaaaggagag acgccgccgt tcattttctc gagcggtatg ccggggacat tgccacgtgg 1167961 cggattcccg caggcggctt ttatatttgg gtgacatttc acaaaaacct gcctgtcagc 1168021 cgtttctttt atgaattgct gaaacggcag gtgcttgtga atcccggcta tatttatgac 1168081 ggtgaagacc gaaacagcat caggctgtca tattcctatg catctcttgg agatttggaa 1168141 actggcatta aagcggcagc tgaaacagca cgccgcctga tgatgtccta ggctttggtt 1168201 atacgatgac agctcccagt gccctggcga aggcaatcgc gtgctcaggt gcgattttgc 1168261 agcctttcaa tttgtcgagg gagacatgaa gctgttcaaa acggcacgtg ctgatgtcca 1168321 tgttttgaag ggacgtgccg gtaaagctgg cgccttccaa ttcgcatccg tcaaagtgtg 1168381 tctgctggag caccgtatcg ctgcattcac tttgcataag agcacagtga tcaaatcgaa 1168441 cttgtttcat atttgagtac gaaaatgagc tgaaatgtcc gtggcattcc tcgaatgaaa 1168501 cattccgcag cgttgcttcc gccacattca ttccaaccat ttttgactgc ttaactgaag 1168561 ttctgtgaat gacagccccg ctgaaatcgg cgtttgataa atcgcatttt tcaaagatca 1168621 catcggtcag ttcaatatgc cgaaaagaca catcgataaa gacgacattt ctgaataccg 1168681 ttttttcaac acatagtctt tcgatatctt cgccgcagat ggtgcaatct tcaaacaaat 1168741 gcatgctgat tacatcatcc tgtgtcacgg catcatgaaa atctgcggtt tgcaggtttt 1168801 ccggtatgtt cggtttttga attgcgattt tattcatgtg atgacatcct ttgctgcccg 1168861 aaaaacagag gcttccgggt tcaatttaat agatcgttaa ggaaattgat acatatagta 1168921 aatcgtgaag agccttttct tggtacagca gcccgcttgt tttgtaagca taaatggaaa 1168981 gcttcctata cgtcaaggcg tttacaggcc gaaaaagcca aagggaacag gaggaatgcg 1169041 gaatggggca ttacatcaaa accgaggagc atgtgacact gtttgtagag gatatcggac 1169101 atggaaggcc gatcatcttt ttgcacgggt ggccgttgaa tcataagatg tttgaatatc 1169161 aaatgaatga gcttccgaaa aggggatttc gttttatcgg cgttgatttg cggggatatg 1169221 ggcaatctga ccgcccttgg gaaggctacg attatgacac gatggccgat gatgtgaaag 1169281 cagtcattta tacgctgcag cttgagaatg cgattcttgc cggtttttca atgggcggcg 1169341 caattgcaat ccgttatatg gcaaggcatg aaggagccga tgttgataag ctgattttac 1169401 tgtctgcggc ggcccccgcg tttacaaaac gcccgggtta tccgtacggg atgaggaagc 1169461 aggatattga cgatatgatt gaattgttca aagctgatcg gcccaaaaca ctggctgatt 1169521 tagggaaaca gttttttgag aaaaaagtgt ctccagagct taggcagtgg tttctcaatc 1169581 tgatgctgga ggcttcctcc tacgggacga tccactcggg catcgcatta agagacgaag 1169641 atctcagaaa ggaacttgct gcaatcaagg tgccgacgct gatcctgcac gggagaaagg 1169701 atagaattgc gccgtttgat tttgcgaaag aattgaagcg cggcatcaaa cagtcggaat 1169761 tggttccgtt tgcaaacagc gggcacggag cattttatga ggaaaaagag aagatcaaca 1169821 gtttgattgc gcagttctcc aactcataag aaaaaacccg acattgatcg ggttttttat 1169881 ataattcctc tgttttgcag tgcgttaatg atgagatcag ctccatcgga aatagaggtc 1169941 tggtcagact caatgatgaa atcgggtgaa agcggcgctt catacggaga atcgatcccg 1170001 gtgaaatgtt tgatctctcc gtttcgcgct tttttataaa gcccttttgg atcgcgctgt 1170061 tcacaaacat gcagcgggca cttcacataa atttcgaaga actcaccttt aggaaagagc 1170121 gctctaacca tgtcccgatc ctctctgaat ggagaaataa aagccgttaa aatcatttgc 1170181 ccgctgtcga caaacagctt cgccacttct ccgatccggc ggatgttttc aatcctgtca 1170241 ccagtctgaa atccaagatc tttgtttaag ccgtggcgga tattatcacc gtcaagcacg 1170301 tagctctgaa tgcccttgcg gtaaagcttt tcatcgacag cattggccag caccgatttt 1170361 ccggagccgg acaaacctgt aaaccaaagg acgcagcttt tgtgtccgtt taaggactgt 1170421 ctgtcagact ttgagatggc agcgggatgc caaatgatgt tcggattgtg tgtcattgca 1170481 attccccgct gttttgcttg atggcaacag gctgttggtg aagtcccttg atcagcacgg 1170541 ctgcgacctc aggccggctg aattctttag gcggcttttt gccttggcgg agaagctctc 1170601 tcacttttgt gcctgataag tggatgtggt ctctcgggct gtgcggacat gttttggagg 1170661 tgcccatgtt tccgcatttt cggcaataaa agctgtgctc aaaaaacagc ggcttgatgc 1170721 ccagctcttc ctctgtgaat gattgaaaaa tattttgggc gtcgtatgtt ccatagtagc 1170781 tgccgacacc cgcgtgatca cggcctacaa taaaatgggt acagccgtaa ttttttcgga 1170841 cgagcgcatg gaaaatcgct tcccgcggac ctgcataacg catggcggca gggaaaaccg 1170901 ataacatgac acgatccttt ggataatagt gattaagcaa agcctggtag ctctccattc 1170961 tgatatcgct ggggatatcg tctgactttg tttctccgac aagtgggtga agcagcagac 1171021 cgtcgaccgt ttctaacgct gttttttgaa tgtattcatg cgctctgtga acagggttcc 1171081 tggtttgaaa gccgacaatc gtcttccagc cgagtttttg aaaggccgct cttgtttcag 1171141 cgggcgttgc ataaaactgt tcgaaagatt tgtcaggcag gctgctgacc gtgataggcc 1171201 ctccgatata gtaatccggg cgcgccagca atttttttac gcctgggtgg gcaggatcgt 1171261 ttgttttaaa aacagacagt gcttcttgtg ttttatcagg ctggtatata tcggtgactg 1171321 tgatcatgcc gtaggtaaca ccgtctttca caagcttgac gtgatctccg gcagacagct 1171381 gtcttgctgt tttttctccg acaggcagcg taatcggcag gctccacggc aagccgtttg 1171441 ccagcctcat ctctttcaca acggaatgat aatctttttc tcccaaaaaa cctgttaacg 1171501 ggctgtagcc gccgatcgca ataagctcca gatcactcag tgcaagctga tccagctctg 1171561 cttggcacgc gcacccttca aaatggcatg cgggatcaca gcggttgatt aatacccctc 1171621 cgtggggttc gtttccattc aacgtgttca acctccattt atacgtttcc ttgttttctt 1171681 ttctgcactt aatgaaagtt tgacatcagc gccttaacat catttcgatt ctcacatcaa 1171741 gaacctgcca tccgctattc ttgatgcagg ccgcattctg ttttctcccg tccggcccat 1171801 cttccagccc tctcatcgtt cgggtccggg gaaggcagtg tacacatttc acagcctatg 1171861 ctcggataat gttgatcgtg cagtttgtta taaggcaaat tgtgcaggcg gatgtacgtc 1171921 caaacgtcat cccatgtcca gtggataagc gggcaaattt tgatgagctc aaacttctgg 1171981 tccaggttta cgtattgaat atgctttctc gttggtgact gatcccggcg cagtcctgaa 1172041 atccaagctg tcatgccgga caggtgcttt ttgagcggtt cgattttccg caattggcag 1172101 cagaggttcg ggttatgctt ccacagctct ccgccgtact tcgtcccctg ttctgttaag 1172161 ctcagctcgg gttcgagcat ctggattgca aatcccggat atcgttcttt gacggtctcg 1172221 atcagctcat atgtttcctg aaaatgaagc ccggtatcca aaaagatgat gtgtgcgttt 1172281 ttgttgattt ttgatattaa gtcgagaagc accattcctt ctgcgccaaa gctgcaggcg 1172341 tacacaatct tttctccgta cgttcggtaa gcccatttca acacatcgag ctcatcgatc 1172401 aattgatccg ttatctgttt ggacagcatg tcgttccaag tgtcatatgt gatggtttcg 1172461 ttcaatgttt tccccccgtt tgcatctgct ttttttatct attgatcgag ttataggcag 1172521 actattcatt ttttgcataa aggttcaggt tttaggtgcc gcgcccgcct aaaatgaggt 1172581 gcggaaccat taagagcccg gctgaatatg ctttttagca aaatggtttt atgcccaagg 1172641 agaggtagta tgccgattgc catttatcag gggcatcatc attcgcttgc cccggcggac 1172701 attaacatcg tcattgatgt catcagagcc tttacggtcg cccattatgc gtttatcggc 1172761 ggggcgaaag agattttgtt ggtccggaca gctgatgaag cctttgcgct gaaagacacc 1172821 tatccggatt atgttttgac gggagaggaa aagggggtcg gtatcagcgg atttgattta 1172881 gataattctc caaaacgtat ggctgggcag aatatgacgg ataaaagcct gatccagaaa 1172941 acaacaaacg gcgtcacagc agcattgggg gcgctgaacg caaagcatct gttcgtaact 1173001 ggattttcca atgccaaaac aacggcacag catgtgaaaa agctcgtcgc aaacgattgt 1173061 gtcataaaca tagtggcttc ccatccatcc ggtgatgacg atatggcatg tgcggagtat 1173121 atcaaaggca tcattgaagg gacaaatgtg gtaacggctg cggaggcgat tgaaagaata 1173181 aaaggctctt ctgttgcgga gaagtttttt gactgccgcc agccattgtt tgattcggaa 1173241 gacatcgttt actgtacaaa agaactgacg ggcgatttcg tgatgaaagt gaaacaagat 1173301 ggagaagttc caacgataga gagggtcata atatgaatga tttttcacta gaattgccag 1173361 tgagaacaaa caagccgaga gaaaccgggc agtccatttt aattgataac ggctatccct 1173421 tgcaattttt caaagatgcg atagccggag cgtccgacta tattgatttt gtgaaattcg 1173481 gctggggcac atcattactt acgaaagatc ttgaagaaaa aatcagcaca ctgaaagaac 1173541 atgacattac atttttcttt ggcggcacac tgtttgaaaa gtacgtaagc cagaaaaaag 1173601 tgaatgaatt tcatcggtac tgcacctatt tcggctgtga atatattgag atttcaaacg 1173661 gtacgctccc gatgacaaat aaagagaaag cggcttacat tgccgatttt tctgatgaat 1173721 ttcttgtgct cagtgaggtg ggcagcaagg atgcggaatt agcaagccgg caaagctctg 1173781 aggaatggct tgaatatatc gttgaggata tggaagcggg cgcggaaaaa gtgattacag 1173841 aagccagaga aagcggaacg ggagggatct gttccagcag cggcgatgtc aggtttcaaa 1173901 ttgttgacga catcatttcc tcggatattg atatcaacag gctgattttt gaagcgccta 1173961 acaaaacgct tcagcaaggg tttattcaaa aaatcgggcc gaatgtgaat cttgccaata 1174021 ttccatttca tgatgccatc gcgttggaaa cgctgcgttt agggctaaga tccgatacct 1174081 tttttctgta aaatagcggc tgcggggctc tcgtcgtgaa gagagcctct gcctattatt 1174141 ttttatggcg gtacataggc gtgagatagg gaagtgaggt caggcggatg ttgtagatga 1174201 agtcgatgac tcttgtcgat atcacctggc atatgagggc ttgaatgacg atgccccagt 1174261 caataataga cgcggtgacc ataaaaatga tgcaattcat gatgagcagg atcgttccag 1174321 gattcccgcc gcggtagata gaaatcatca gagcaagggc tccgaatcct ccgttcgaaa 1174381 ttttatattt gtataaaagt ccgattccga gtcccaataa cactgcgccg cttgccagat 1174441 caagccacag gttagatgtg atatcaggaa aaactgcatc aaagatcaat accgagacag 1174501 aggtgacggt gatagaagcg agggtgccgg tgaatgttct catctccagc cattttaaag 1174561 cggtaaaaag cattgataca ttcacagccc acactgaaaa tccgtggggg atttgaaaca 1174621 gataatgcaa tagcaccgca atacctgctg caccgcctgt cggaatatca tgcggaaata 1174681 aaaacaagga catgccgagt ccttgtagta cgccgcctac gacaatcata aacgtaagtt 1174741 ttgctttcat cagcagttca gccattaagt catttgctcc tttatgaaaa gacttgtccg 1174801 ctgttttcat tttatgaggc tgtccattat ttatgtctca aaataaagaa atggcccagc 1174861 ttaataggct gagccatccc acttgtagcg attgacgatc tccatattga tctctgtgcc 1174921 aatgcctttt cctttcggga tgtggaccat tccttttgaa ggctgcaggc tgacgagatc 1174981 tgtaaaagga ttctccatga cgtcccactc gatcggttca atgtgatcgt tcttcatttt 1175041 agaccatggg ggcagacagg cttgtgcaaa taaagcatag agccgtgaga gcgatccgtc 1175101 atatgcatgg gcggatgctc tgacgccgaa ataacgcgcg agctggaggc agtcccgaaa 1175161 ctcatcaatt ccgttgacat gcatgacatc gggctgaatg atatccaaac agcgctgtga 1175221 aaggagaggc acatattgcg ccgggccttt catgttttct ccgccggcaa caggaacaga 1175281 caaacggctt cgaagcatag cgtaatcctg cggctgatca aagggcaaag gctcctcaag 1175341 ccagccaatg ttcgtccatt cggagaaata gcgctcccat ttaaaagccg cagcggcatc 1175401 gtagctttgg tttgcgtcca gaatcatcgt aatggagctg cctgctgtat gctgcagcgc 1175461 attgatgtgc cggacatcct ccttgaatga agtcccgcca attttgactt tgatttgctc 1175521 aaaacctttt ttcaactggg cttcaacatt ggagactgag cggctgatcc attgcgggga 1175581 gtctgagtac gattgaaaag acgcgtacac aggaatctcc tctctgtatc gcccgcccca 1175641 taattcgcaa accgaacaat ccgcagcttt ggctgcaatc tctgtcagcg ccatgcttac 1175701 agcggaggcc gcccgctggt gccatttttg aatcgtgcgc actaatgaca ggcggctgcc 1175761 agcctgtttt cctaatagaa atgggatgat ccgcttcgta aaaccgacat ggagagcagg 1175821 gagccaatca acgcattctc cccagccgtc tatcccgctt tcggtgataa tcctgatgag 1175881 ataacaagtc cgatatcgtt taaacccatt ggcatctccg tatggctttt ctaatcgatg 1175941 aaatagcgga aaggtttcaa tccgtacaat tttcacactg ggtgctacct ttcctcagcg 1176001 ggctggagcc gattgccagc cattttaggg tcttcttttt cttttgtttc ttcattgttt 1176061 tgcttcacat ggatgagcat catcacaaga atcccgacaa cgagagtcaa tcccgcgatg 1176121 cttaaaaaca tgccgggtct ggaccattgc atcaggcggc cgaaaatcgg aggaccgatc 1176181 gctaccccta agaaacgtac agagccgtac agcgaggtga caaatccccg tctttctttg 1176241 ccgacagccc cggtaatgaa actgttcaca caaggaagga caagacctga gcctatactg 1176301 ctcagtacaa gaacactgat aaaaaggaca agattttcaa tgaatgacag tgccgcgtag 1176361 gatacggtca tgaacgccaa tccaagtacg atcagctttt tcattaacga ttgcttttgc 1176421 ccgattttgc ttcctgttgt ataggacgtc acacacataa ccaaaagcgg gatcgctaaa 1176481 attaagcctt ttttcacgcc gtcggtgtcg tatgtttttt caagaacatc tgagagataa 1176541 aacaggatgc cgaataaagt aaacaaacag gtcgcaccgg ctaaataagc ggtaaacagc 1176601 catctgcctt catgtttaaa gacacttaac agcccttttg catattgtcc gattggtggc 1176661 ggttcttttt cctttttctt ttctttaata aaaatccaag tcagtacgat cgaaatgata 1176721 caaaacacag gaaaggcaaa aaacgcgcca taccagacaa gcagggcgat cagcgagcca 1176781 atgatcggcg atagcacttt ccccatgccg tttgaagctt caacaaggcc gagcaccttg 1176841 ctctcctggg cgcctttaaa cagatctccc gtcagtgcca tggcaattgg gccggttccg 1176901 gctgccccga ttccctgtaa cgctcgtcct gccatgaccc aaggataggc attgtcaaaa 1176961 aaacctgccg caaacccggc taacaaaccg ccggcaccat acaaaattaa gcagggaata 1177021 atgatgactt tccttgagaa tcggtctgcg agataaccga caatcggaat cgcaaatgct 1177081 gcaatcaagg aaaatactgt gatcacgaga ctgacttgaa attgtgataa atgaagttca 1177141 gatttcattt ttggcaaaat cggaataagc atcgagtttc ctagggttaa tattaaaggg 1177201 attgaaccga ttgccacaat cgtcattccg ttattttgtt ttgatgattc catctcagag 1177261 cacactcctt ttcttctgct tagaatgtcc ctgatggctt cgtttattca gcgatcagac 1177321 agcaaaaaac cgaacagaag atacctgttc gggaaaaaag agggttaacc gagagcctgt 1177381 gaaatcaaag catataagtg tccattttga ataggcgctt ttttctgata gaacaaaatc 1177441 ggaggttcat catctttatg aaatcccatt tctatcaggc tgtcatgcag agacgtgtgt 1177501 tcactcggta tatcgattcg catcggccct tgtttgccgg ccgccagcct tgtaattatc 1177561 tgtgctgcaa catctgatga tggagcgatg atagggccga atttcaaatt ggccggtgtc 1177621 tgtacagaaa gtccgtagcc aatgagctgt ccgtcctgat ttctggcgat gatacattcg 1177681 catgaagcag aaataagctg ctgcaaaagg tttgatcgat ctccgccaaa ggcagccaga 1177741 tccgccgcgg ttaagtcgtg aaagtcttgt tctctaaagg atgtcagttc agcatcaagc 1177801 ttttttgtat aaggttgaaa actgtgacag ctgtactttc gcactgaacc tgccgtatga 1177861 aaacctgctt tttcataaag cggcaaacct tcttttgtgg cgcaaagcct gatggcggtg 1177921 ttttcatccg tttgggtaat acaggcgttt accatacgcc ggccaagacc gagccgttga 1177981 tattccttgt caacgataac aaggccgata gaagtaagac ggccaaacaa aaacaagccg 1178041 atgcaggaaa taatatcacc gctgacattt tgataaccga aaaagcgtcc ctgctgaaca 1178101 agcagtttca gctcttgttc gccataatcc ggccacccgg cttgcccgca aagccgcaat 1178161 aagccggaaa cgtgttcttc atgaagctta atcagttcat ctactacgtc cataagatca 1178221 cctgcttgtt ctaagtgttt tgtacatgac aatatgattg ccaatgccgg gaatgtcaaa 1178281 tggttcgcca agttccttcc agccaagctt ggcatagtag cccttgacat ggtgtcttgc 1178341 gttgcaccat accgcctgaa cgccgctctc cgccagtttg tgctccgcgt gtttgatcag 1178401 cgtgcttcca gctttttgat cgcgatatcc ctcgagcgtt gccatgcctc tcagccgata 1178461 cgcagaggct tccgttaata aaggctgact ttgcggggaa aaagaagcga tgctgatcag 1178521 cgttccatca taaaacacgc cgagatgaaa ggagccttct gcgtgatcct ctttatattt 1178581 gcattgttcg atggattgat ggggacgcag aatgcgatgc cggatttcat atgtatcttc 1178641 cacggaaatg gttttgactt cgagcataat gttcctcctc atgattgttt ttctatatcg 1178701 taacacgaat ctcgttgaaa aagactgccc gattcgatca ggcagtcttt tggaaattaa 1178761 tgcaaaaaga tattttggcg ctgctcatct ttttgctgaa tatatgatgt gagctcagcg 1178821 gttaagtcag atctgaggaa aggcgttatc aagtagatgc cgttaaacag ctcgcatgcc 1178881 gtatccagca gggagcgtgc aattgcaagg ccttccgcct tttgcttttc tttatcttca 1178941 ccggcatggg ccattttttc gcgaatcgta tcagacagct taatgccggg aatttcatta 1179001 tggatgaatt cggcattccg gctgcttgtc agcggcatga tgccgatata gatcggcgtc 1179061 ttcagatgtt ttgtttcgtt atggatatcg acaagctgct gctcggaata gacaggctga 1179121 gaaacaaaat aatctgcgcc gcaatctatt tttttctcaa gccgttttac cgctttatcc 1179181 agatggcgga cgttaggatt aaatgcggcg gcaactgaga aattcgtttt cttgccgagc 1179241 ggttttccag acagagacag accttcattg aattgtttga tcagcctgat taaatcaaaa 1179301 gatgttaaat catatacaga cgtcgcccca ggaaaatccc cgattttaga agggtcacct 1179361 gtaatagcaa gcacgtcatt cagccctaac gtatcaaggc ccattaaatg tgactgtaag 1179421 ccgataatgt tacggtcacg gcacgtaata tggacaaggg aacgcatatc gagctgctgc 1179481 ttgacaaggg cgccgcaggc aacattgctg atccgcgggg tcgccaaaga attgtcggcg 1179541 agtgtcaggg catcgattcc cgcttctttt aattcagcag cagcggacag aaatttgtca 1179601 aagcttagtt ttttcggcgg gtccagctct acgataatag agcgtttttt cgctgcgatc 1179661 tcatccaggc cgggctcggt tcgctcgtga tgaacagaaa tgaattcttt cgcccgggtt 1179721 ttgacttctt tttccgtaat cggagccagc ccgccaaccg cttccgccat cgccctgatg 1179781 tgattcggcg ttgtgccgca gcagccgccg ataatccgcg caccttgctt acggaattct 1179841 gacgcgctgt tttgaaaata cgtgtcgtct gtttcataga cgagccgtcc ctcttcaagc 1179901 gaaggaagac tgctgttcgg ataaacggat aagaatacgt catcaaaaat cggcacttcg 1179961 cttagcgctt caatcatgtg ataagggccg aggcggcagt taatgccgac aatatcagct 1180021 ccgagatccg caatcgagcg caatgcgtca gaaagcggcg ttccgtcctg caatacgcct 1180081 tgctcgtgca tggagacatt gagcataatc ggaagatcag tctctttgcg cgcgattttc 1180141 agcacttcac gggcttcttc caaatcataa tatgtttcta acagcaagcc atccggctct 1180201 tcatgcagca gcagatacag ctgctcgcgg aagctgcgct taatttcgtc aagactgtat 1180261 gcgtttttat taaatgtgcg tatgccgccc atcgttccaa gcacgtatgc atcgcctgct 1180321 gaagcccgcg cgatctttac ggcctcctga ttcatttttt tgatgtcatc ctcaagcccg 1180381 tgtctggata atttaatata gttggctccg tacgtattcg tttgaataat gttggctccc 1180441 gcttcaacgt acgctttatg tatgcgctga atttcctccg gctttgaaat attgagctcc 1180501 tcaaaacacc tgtcaatgcc ataggagtag aggagcgtcc ccatggcgcc gtcaccgatt 1180561 aacacctgtc tttgcaaatc ttctaaaagt cccattgtct gcctccttta ttcacatcag 1180621 caaggaaaaa agagaaataa aaaaagtcct cttaagaaga agactttgtc agtgattttg 1180681 tctcttctta tcttccaagc tgttcgagct tgctggattt agcaccttgg tcatggctga 1180741 tcgccattac accggttgct gaagcttcgt cgggccagtc cctctgcttc tcttgataag 1180801 aacggatatg aaattttcgt gtcaggaagt gccaaaagat atctggcgtt tttccctttc 1180861 tccaaattta ccgaaaataa agacaataat caataggaat cagaaaattt atctgaaatt 1180921 tataaattga acgtcaattg gcagatctgc tccccgtaca gctgagataa tctgctgcag 1180981 gtcatctttg ttttttccgg tgacacgcac ttgatcatcc tgcacctgag actttacttt 1181041 cagtccggag tttttgatga tcgtattgat tttttttgcg ttgtccttgt caatgccttg 1181101 aacaagcttt gcacgctggc gcaccgttcc gcctgacgcg ttttcaacct tgccgtaatc 1181161 aatgtttttt gtcggtacgt ttcgtttaat caatttgctg accagcacat ctttcagctg 1181221 gcttaatttg aattcgtcat cggaaacgag gaccagctcc tctttatcta aagaaatgtc 1181281 gcttttgctg cctttaaagt catatcgggt actgatttcc ttcagtgcga tttggattgc 1181341 gttttgcact tcaggcaatt ccaccttgga tacaatatca aatgaacttt cttttgccat 1181401 atgaaaacct ccataacatt taacttatgt gttgattata gtagaataaa gagaaacttc 1181461 caacagaaca aagaatcaat ttgtgatgat tggaaaaaat gttaacaaaa tccgcagaga 1181521 ataagcggaa caggaaggac gatagcatga gaccagggca gcaattaacc ttgagtatag 1181581 atcaccaaac cgacttcggt tactttttaa ccgatgggga agatacgatt ctcttacata 1181641 acagtgaaat gactgaggat atcgaggaca gagacgaagt agaagtcttt atatacgtag 1181701 accagcagga aaggcttgcg gccacgatga aaattccgat catcagcgcg gatgaatatg 1181761 gctgggttga agtggtggat aaagtggaag atatgggcgt tttcgttgat gtcggtttat 1181821 cgaaggacgc actagtcgca actgagcatt tgccgccgta cgaagatgtc tggccgcaaa 1181881 aaggggacaa actttactgt atgctgaagg tgacgaaccg ggggcgcatg tttgcgaaac 1181941 cagcgccgga agatatcatc agcgaactgt ttaccgacgc ttcagaagat ctgatgaata 1182001 aagagctgac aggtacggtg tacaggctga tcgcatcggg ttcattcgtg atcacggatg 1182061 acggtatccg ctgttttatt cacccgtcag aaagaaaaga ggagccaaga ctgggttcaa 1182121 gagtcacagg ccgggtgatt caagtgaaag aagacggttc agtcaacttg tcgctgcttc 1182181 cgagaaaaca ggatgcaatg tcagttgatg ctgagtgcat tctaacgtat atgagaatga 1182241 gaaacggtgc catgccgtac agtgacaaaa gccagcctga cgatatcaga gaacgtttta 1182301 atatgagcaa agccgccttt aaacgcgcgc tgggccattt gatgaaaaac ggaaaagtgt 1182361 atcaggaaaa tggatggaca tacgagaaaa aatagcatga aaacggctcg cctgcagcag 1182421 actgcggagc gagccgtttt tttatgtcta gtttaattca tcaaccagcg ttctgattgc 1182481 catttcgcga tccacattgt ctgaaatcgc aatcggcgta atatcaatgg cgagaatgat 1182541 cagaatcagg gcacctgctg cagcaacata agaaacataa tagaaatagt tagcggtatc 1182601 aacagtgttg acaagctcgg cctgaactct ggatgtatca tccttagaag cggcgatttc 1182661 ctttgcagct tctacttttt cttcaacgat ttgacctgct tttttcagca gttcatccac 1182721 tttcaatgca tctttgctgt aaacagcttt cttcaggtta tcaaaaaagt cagcatcctc 1182781 ttttttaata tcagcgacaa cctgattggc aaaagccttt gcctgttttg tgttgagttt 1182841 gtctgtcatc gctttattaa agacctctgg aagctgtttg ccaacttccc cttgggcaaa 1182901 cacaaagcct ttaaaaattt cctcacctga atactcaagc tgctttgcct gtgccacact 1182961 ttcttgctgc ttcaccaaaa acacagtcgt caccaataca accgacaaaa atactagaaa 1183021 cgccttcttc aaactgaaac ctctcccttc ttgtgttttt tattccacaa cagtctgcga 1183081 atatatgtaa attgaatcgt ggaatcgata ggagtgagat acaatatcaa aatgccggcc 1183141 atgataatcg aaaaactgat gaggcccagc atgactgcaa aaatctcatg cataaaaaca 1183201 gcgatgatca aaatcaatct ccaatgcttc ttcggcgcaa acagtgccgc gaagatgaca 1183261 atttgaacca gcagcgtccc ccatgtcgga atcaccacga acggacttgt tacaattggc 1183321 ttcgttaacg cctgaaaaaa gccgttgaag ccaatggttt tttcctgggc gaaataatag 1183381 acggccgttc cgtccaccca ttcctgctga gatagcttag cgacggtaga gtgaaaataa 1183441 agcaccgcca cttggattct gatcacaaaa taagaaataa aagctgttat ttttccaagt 1183501 gttcttttgc cctctatagg tctcgtactc caatgccatt ttctcggatc ggtcagcgtg 1183561 atgggaagca ataaaaaggt catgactgct gctgcctgct cgcctccgtc gatgacgatc 1183621 agcgatgact gcaggctgta actgacatac caatgcagaa ccccggtgat tctggggcgc 1183681 cagccaatga caacaagcac cagaatggca atgcagaccc atctgaaaag atttaacatc 1183741 atatagttat tttcgccgag acaaaagaga ctgagattca ttttacaagc tggatagctg 1183801 ctgatcccgc tggctggctt cataatgagg ctcgggtgat tgatgagcag cgtcagcagg 1183861 ctggatagcg caatgatgct tcgcgcgagg ccatatacat ttgtccacgg gtttctttcg 1183921 tcccatctgg tgatggtctg ttttatgttt tcgagcatga gatcacaacc ttgactatgc 1183981 tttttacctg ataagacgaa ggggtatatt tagaatagct ccaaggaaca atatcctctt 1184041 tcgtcaaata gtagctgcca caaagcagcg ggcggggagc gggtgttttt aattgcacgg 1184101 ttttggcttt gcttttgcat gcgccgaggt ccttttcttt acatgctgtc cactgttcct 1184161 tgccgacttg gctgtagatc acgcccattt caacgccttg tgaccgccca taccgataca 1184221 ggccgaatag gttgtcagcc ctcatattgg gccatctgac cttggcgctg gcattttcag 1184281 cctcatataa gccgattgca gtatcacgcg gatttttgct aaaaaagccc cagccctgag 1184341 ggaggatgct ggacatgaga aatttggagt cctttgtcag cggaatcggg gttgtcccta 1184401 agctgccaat aatagaaaac agaaatagcg aaccccaaag gattgaaaaa atgacaaaaa 1184461 atgatatcga tttctgcatt cgactgctcc ttttaacctg aagaatcgtt tttacacttt 1184521 tcataatata aaaacattta tgtaataaaa aggttaaaaa gtatgagaaa ttccattttt 1184581 gttaaaagga aaaacaggac attttacact gctatatgtg attgatatat agtgtttttt 1184641 tcgatatatt taaaccatga aaacgaatca agttaatgac cgctggattg ttcaatttcg 1184701 aaaagggatt ttcgagctgg ccatcctatc ccttctgcgt tctaaaccga tgtacggtta 1184761 tgagctgacg tcatccttaa aaaccacctc ggcgctggct atttcagagg gagcgattta 1184821 tccgattttg aaacgtatga ccgagaaggg atggatcgaa tttttttggg aagattcact 1184881 ggacggcccg aaaagaaagt attacaaaat gacgcaaaaa ggagaagaaa tgttaaaaga 1184941 acggctggag aaatacctgg aaacccatca agccttactg tctttatcgg gggatttgct 1185001 atgaatggac agcttatcat tgaccgatac atggaggaac taaatgcaga gctggcgaat 1185061 atgcctgatg tagagagaga aaacgctatc gacgaattaa aggggcatat caccgctttc 1185121 gttcaagaca gaatcaaagc cggccttagt gaagaggaac tgcaggaagc tgttgaatct 1185181 gaattttctc atccgaagga gcttgccgaa ttgatgatgg gtgatggggg agagacgaaa 1185241 aggaggaggt ctttattggg caaaagctgg atttcggtcc ttctcattgt cacgattatc 1185301 gccctgccgc tgctgccgtc cgacttcaga catctgccgc tggctgttta tttaatggtg 1185361 ctcgccggat atgtatggaa gcggaaaaaa ttggtgatgt ttgcaggtgt cagaaaaaac 1185421 aaaatgcgct ctcaaaagga gattgtcaag atttcgcgag tcggtgcggt ttatctgctg 1185481 tttttagcag tggtgctcct tttgagcccg ttcctcaatg cgcttgtcgt cctgctgctg 1185541 attgcagtaa gctgcgccgc tttttttctt tttcttaaca tcaagtaatc ttgtaggagg 1185601 ctgtaagatg gaaatcagca tcaattatct attaattgtc atcgcgcttt tattctttgt 1185661 ggttgcctat tttgtcggaa tcaaaaaaca aacctggatg ttggctgggt ttaacgaggc 1185721 gcgtatacgg gataaagatc ggctggccag aatagcaggc tactttttct tgaattccgg 1185781 tttgttcatt ttgctgaata gttttatctc atttcaaggt caggagcagc tcatacctcc 1185841 gcttatactg gcatatggag caggggttat tatttatgtc aataaaaaat tagtagagta 1185901 gaaaaagaag ggcagagcga aatatctctg cccttctttt ttgggaaaat aagaacgaag 1185961 caccacatac aagtttttgt atttttgata ggatgaagaa aaatggtaga ttccaaaata 1186021 ggaaggatgt ggtgttttgc gcaacttgac caagacatct ctattactgg ccggcttatg 1186081 cacagcggcc caaatggttt ttgtaacaca tgcctcagct gaagaaagca tcgaatacga 1186141 ccatacgtat caaacccctt catacatcat cgaaaagtca ccgcagaagc cggtacaaaa 1186201 cacaacccag aaagaatcgc tattttccta tcttgacaag catcaaacgc agtttaagct 1186261 caaagggaat gcgaacagcc attttcgcgt ttcgaaaacc ataaaggatc caaagacaaa 1186321 acaaacgttt tttaaattaa cggaggttta caaaggaatt ccgatttacg gctttgaaca 1186381 agcggtcgcg atgaaggaaa acaaacaagt gaaaagtttc tttggaaagg tgcatccgca 1186441 aatcaaggac gtctccgtca caccgtctat ttctgagaaa aaagcaatac atacagcaag 1186501 gcgtgagctc gaggcttcca ttggaaaaat cgaatatctt gatggggaac caaaaggcga 1186561 attatatatc tatccacacg acggtgaata tgatctcgcc taccttgtga gactctcgac 1186621 atctgaacct gagcctggct attggcatta tttcatcgat gccaaaaacg gaaaggtcat 1186681 cgagtccttt aatgccattc atgaagcggc aggtacagga atcggcgtgt caggtgatga 1186741 aaaaagcttt gacgtcacag aacaaaatgg gcgcttttat ttggctgacg aaacaagggg 1186801 aaaagggatc aatacatttg acgcgaagaa cctgaacgaa accttgttta cgcttttgtc 1186861 tcaactgatc gggtatacgg gcaaagaaat agtcagcggc acgtccgtat ttaatgaacc 1186921 tgcggctgta gacgcacacg caaatgcgca agccgtttac gattattaca gcaagacatt 1186981 tggccgtgat tcttttgatc aaaacggagc aaggattacg tctaccgtgc atgtcggcaa 1187041 acaatggaac aatgctgcgt ggaacggtgt ccagatggta tacggggatg gagacggttc 1187101 gaaatttaag ccgctgtctg gatcgctcga cattgtcgcg catgaaatca cacacgcagt 1187161 cacacagtat tccgccggtc ttttatatca aggagaaccc ggtgcattaa atgagtccat 1187221 ttctgacatt atgggcgcga tggctgaccg tgatgattgg gagatcggcg aagatgtcta 1187281 tactcctggt attgcaggag attcattgcg gtcattggag gacccatcta agcagggaaa 1187341 tccagatcat tactcgaacc gctacacagg aacagaggat tatggcggag tccatatcaa 1187401 ttcgtccatt cacaataaag cagcttatct tcttgcagaa ggaggcgtgc accacggtgt 1187461 acaggttgaa gggattgggc gtgaagcaag tgaacaaatt tactatcggg ctttaacata 1187521 ttatgtaacg gcatctacag atttcagcat gatgaagcaa gcggcgattg aagctgccaa 1187581 tgatttatac ggtgaaggct cgaagcaatc agcttcagtc gaaaaggcgt atgaggctgt 1187641 cggcattcta tgagcaaaca aaaacagtca ggacacagag tctgactgtt tttgtttgct 1187701 cattttctta aaaagaatat cgccaatgta cctggaccgg catgcgagcc gatggctgaa 1187761 ctgattggat gcataatgat ttctttcggc ttgaacgctt cctcaatcag gtgtttcata 1187821 tccgtggctt tttctttgtt cgcggcgtag ctaatcccga cggtttgatt gctccaatca 1187881 tccccgcgct ctttcataag ctcgatgatc cgtttgaaaa gtttcttctg tccgcgaatt 1187941 ttttccagag gcacaagctt gccgtcctcc atctgaagca gcggtttaat attcaacagg 1188001 ccgccgacaa aagcggacgt tttggatatc cggccgcccc tcgcgagata tgttaaatca 1188061 tcaacggtaa aaatgtgttc aagctggctg caaaagttct ttacagacgt ttcaatttct 1188121 tgtattgtat tcccgttgat acagagatcg gcagcatgcc ggacagccag accgtatcct 1188181 aatgaagcgc atttggaatc aatgacccgc aaatcgaaat cggggaattc ctccttcact 1188241 tcattggcga tcattacagc tgtctgatac gtgccggaga gacctgagga aaaggcaatg 1188301 taaagagcgg gatcacctgt ttcggcatat tgcaaaaaca catttttaat cgtttgcggt 1188361 gaggcttggg acgtcttagg cgtttctcca ttttgcatcg cttcaaatat ttgatccgca 1188421 tgaattgtga ctgcatcttc gaattcttta tcgccgagag aaaccctgag cggaataaag 1188481 ccaatgcctt tttcttcaaa ataagaacga ggcaaatcag tggcgctgtc agcgatgaga 1188541 tgaactgtca tattgcttcc cttctttccg ttatcgctcg ttatcatgag agttaagcca 1188601 actatatcat attaatttgc caaaatcgtg ttcaaatatt tgttttaagg gaaaacataa 1188661 taaagaagaa agagcggagg aacatgccat ggtactagat caaacaaaaa aattactcat 1188721 cgtcatcatc ggcgctttac tcaatgctgc cgggctgaac ttatttttga tacctgcaga 1188781 tgtatatgcc agcggattta caggtgttgc ccagctttta tcaagcgtcg ttgatcaata 1188841 tgcccccttt tacatatcga cgggaacgct cttgttcctc ttaaacattc cggtcggtat 1188901 tttaggatgg ctgaaggtcg gcaaatcgtt tacagtgtac agcattttaa gtgtcgcact 1188961 cactactctg tttatgggga tcctgccgga aacaagcctg tcacatgaca ttttgctgaa 1189021 cgcggtgttc ggcggcgtca tttccgcagt cggtatcggc ttaacattaa aatacggagc 1189081 ttcgacaggc gggcttgata tcgtcgccat ggtacttgca aagtggaagg ataaacccgt 1189141 cggcacgtat ttcttcattc tgaacgggat tatcatcttg acggcaggat tattgcaagg 1189201 ttgggagaaa gcattatata ccctggttac actatatgtg acaacgaggg tgatcgacgc 1189261 cattcacact cgccacatga agcttacggc aatgattgtg acgaaaaaag cggacgaaat 1189321 caaggaagcc atttacggaa aaatggtgcg cggcatcaca actgttccgg caaaaggagc 1189381 atttacgaac gaacagaaag aaatgatgat tatcgtcatc acgaggtatg aactgtacga 1189441 tttagaaaag atcgtcaaag aagttgatcc aaaagcattt acgaacatcg ttcaaacgac 1189501 agggattttt ggtttcttta gaaaagactg acgaaagcag gtggaagtcg tgaaacggct 1189561 gcttgtgatg ctcctccccg tgctgctttt gataggctgc gggaaagatg agcagacaga 1189621 acccgataag gaggtatcag gcggaatgga gaatcaagag gttgttttat ctattgacgc 1189681 aattcaggag cctgaacaaa tcaagtttaa catgtcgctg aagaaccaaa gcgaacgtgc 1189741 tattgagttt caattcagca cagggcaaaa atttgaactt gtcgtgtatg attctgagca 1189801 caaagaaaga taccgttatt cgaaagaaaa aatgtttacg caggcttttc aaaacctgac 1189861 gcttgaatct ggagaaacat atgatttctc tgatgtgtgg aaggaagtcc ctgagcccgg 1189921 aacctatgag gtaaaggtga catttaaggg cagggcggaa aatctcaagc aggttcaggc 1189981 tgttcagcag tttgaagtca aataagaggc tatggcgagt cgccatagcc tttttttatt 1190041 gcagtttgtc cagctgattt tgaaattgat gcaactgttg acgttccgca tctgtcgaat 1190101 tggcatacgc agaagataca gcatttttgg ctctcagaat cgcttgctcc tgatcgcctt 1190161 cctcaaagcc gtttgtcacc atgaccgcct gttgaacaaa tgattttgcc tgctgaaaca 1190221 gttcatttct catttaatat tcatactgcc tttcagccga gtctcgtgcc gcggcatgct 1190281 ggtgagcttc ttctaaagta gaccgatatg gaaatcttgc ggcgtgtagc ccgatggagt 1190341 ctttaccctg ctgaataaac cttctggatt tgcttcgttt acccattttg agactgcccc 1190401 cttccatact ttgacgagat gagtcgtctt caatagtatg gtggggtaaa gtaaggttta 1190461 tgagtgggaa aaattaatac ggaccttctt taaagtgaga aatattcttt caaaaacctt 1190521 gccacgccgt cctcttcatt tgtggccgta gttcggttgg caatctgctt gaccgcgtca 1190581 attccatttc ccattgcaac gccgcagcct gcaaattcaa gcatttccaa atcgttatcc 1190641 tcatctccaa aagcaatgat ccgctccctc ggcacgccgt aataatcgct gattttctgc 1190701 aggccgaccg ctttattcat gccgcttttg ataatttcaa tgacatgcca aggagcggcc 1190761 catcttctat ggtcgatcac ctcggcatgc acatccgata aatatgagcg tattgccggc 1190821 acatcctctt cctttgcatg tatgagtacg gacgtcacat cttcaccgag attttcccgc 1190881 aagtctccga ccgttacatt tgttgtgttc atgttaaagg catctatcag gtgctcatca 1190941 tggtaatgaa agtatacgtc gtcaatcact tcagcaagca cgttatgtac gttgtagctc 1191001 tcgctgatat ccacgagctg tttgacaaca tcaagcggca gtgacgtatg ataccgtccc 1191061 cagctgtcgt cttgcggatg atggacaaat gctccgttaa aattgacaat tggcgttgtc 1191121 agctccatct gctggtagta catggaactt gaacgatacg gacggcctgt tgagatgcag 1191181 acataatgcc cgtcatcttt taggcgctgt atcgtatgaa gggtgttttc agatatggtt 1191241 ttatcatcct ttaataatgt tccatctaaa tctaatgcga ttaaataggg ttttgtctcc 1191301 atgaaaagct cctttaacct tagattttgc ttgttttgcc ttacttacag tgtagctttt 1191361 taccatcttt attgtctaca tgttacactt atgattatgg ttatcctaag gaggggcaca 1191421 ttgtgataca aattgagaat caaaccgttt ccggtattcc gtttttacat attgtaaagg 1191481 aagagaacag gcaccgcgct gttcctctcg tgatctttat acatggtttt acaagcgcga 1191541 aggaacacaa ccttcatatt gcttatctgc ttgcggagaa gggttttaga gccgttctgc 1191601 cggaggcttt gcaccatggg gaacggggag aagaaatggc tgttgaagag ctggcggggc 1191661 atttttggga tatcgtcctc aacgagattg aagagatcgg cgtacttaaa aaccattttg 1191721 aaaaagaggg cctgatagac ggcggccgca tcggtctcgc aggcacgtca atgggcggca 1191781 tcacaacgct tggcgctttg actgcatatg attggataaa agccggcgtc agcctgatgg 1191841 gaagcccgaa ttacgtggag ctgtttcagc agcagattga ccatattcaa tctcagggca 1191901 ttgaaatcga tgtgccggaa gagaaggtac agcagctgat gaaacgtctc gagttgcggg 1191961 atctcagcct tcagccggag aaactgcaac agcgcccgct tttattttgg cacggcgcaa 1192021 aagataaagt tgtgccttac gcgccgaccc ggaaatttta tgacacgatt aaatcccatt 1192081 acagcgagca gccggaacgc ctgcaattta tcggagatga aaacgctgac cataaagtcc 1192141 cgcgggcagc tgtgttaaaa acgattgaat ggtttgaaac gtacttataa agcactaagt 1192201 tattaacaag agctgaattt acgttatact gtagaaaaaa ggagtgaggg aacgtggaag 1192261 aagcattaaa agaaaacatc atgggcgccc tggaacaggt tgtcgatcct gagcttggcg 1192321 ttgatatcgt gaacctcggc ttggtatatg acgttgatat ggatgaagat ggcttgacgc 1192381 acatcaccat gacgctaaca tcaatgggat gccctttagc gccgattatc gtggatgagg 1192441 tgaaaaaagc attagcggac cttcctgaag tgaaagacac agaggttcac attgtatgga 1192501 atccgccttg gactagggat aaaatgtcca gatacgcaaa aattgcgctt ggcattcaat 1192561 aaaacaaaaa aggacagcct gacatgtgag gctgtccttt tttacagctg aaaggagtga 1192621 aaggaaatga tgtacctgct ggcagtttta tgcccgccgc ttgctgtttt gttttcggga 1192681 aaaccgtttc aggccttgct gaatctcata ttgacctgta tcttttggct gccgggcgcg 1192741 attcacgcct gctttatcgt cgccgaccgc cgtgccgaaa aacgggcaag aagataattt 1192801 ggaaaaatga ggacgcagtc atggtataat ggtcataaaa acagcaggga gagcactatg 1192861 aaaaagaaat tgcttgcatt cgcgctttgt actggcgcgt atgcggccct gtttgcgtac 1192921 tctgtgaact cagagcaaaa aacagccaca agcgagatga cggatgtcag ccgcctgatg 1192981 cctgtaaaaa taaagcagac agtgaaaggg caggaagagg aaatgctcat tgacacagtc 1193041 aaagaggcaa atcgaaaaaa cataaaaatt tcaatcgccg gggcccagca ctccatgggc 1193101 ggccatacat attatgagga cggcatcgtt ctcgacatga cgggctacaa caaaatcctg 1193161 tcactcgatc aagagaagaa aaccatcagg gtgcaaagcg gtgcaacgtg gaatgatatc 1193221 cagaaatacg tgaatccata cggactcgcg gtaaaagtca tgcagtcaca aaacattttt 1193281 acaatcggcg gatctctcag cgcaaatgca cacggacgtg atattcgcta cggctcgcta 1193341 attgatacag tcaaatcatt ccggctttta aaagctgacg ggatgattat cactgtcact 1193401 ccaaaagatg atttgtttac ggcggtcatc ggagggtacg gcctttttgg cgtgattctt 1193461 gatgtaacgc ttgagctgac agatgatgag ctgtatgtca tgaagacaga aaaaatgaat 1193521 tacagcacat actcagacta tttttcaaag catgtaaaag gaaatccaga tgtccgaatg 1193581 catctggcgc gaatttcaac agcgaaaaaa ggatttctga aagacatgta tgtcacgaat 1193641 tacgtattgg ctaatcatca ggatcagctg tcctcataca gcgaacttaa agaagacgag 1193701 tatacgggag ccacaaagtt tgcactcggc ttgtcaagac ggtatgaatg ggggaggaat 1193761 tggctgtggg acacacagca atcctatttc ctgagccaga acggcacaga gatttcacgc 1193821 aataacgtca tgcggtccga atcaaagttt cttgagtatg aaaacaatga caacacagat 1193881 gttttgcaag aatactttgt gcccgtgaag gagtatgggt cctatattga tgacctgaga 1193941 caaacgctgt cggacgaaga tctgaacctg ctgaacatta cgatccgcta cgtgcagaaa 1194001 aatgaaaagg ccgacctttc ctatgcgaag gacgatatgt tttcgctcgt actattaata 1194061 aacgagggct tttcaaaaga agaccaggca gataccgccc gaatcatcag gcgcatgaca 1194121 gacgttgcca tcaagcacgg cggcagctat tatctgcctt atatgaccta ccagacaaaa 1194181 gcgcaaatga gacaggcata tccgaaaagt gaagcgtttt ttcagaaaaa acgaacctat 1194241 gacccggatg agcgctttat gaattacttt tatcagaggt ataaataatg gggaaaaaca 1194301 aattaaaatg gctgacatta tcacaaagca gcgtgttttt cgcaagcagc ttaatctttc 1194361 cgttttatat tctgtttgtg aaaaatatcg gctcaagcta cacacagttc ggtttttcct 1194421 acggattgtt cgggttgagc ggagcgctta tttacccgct cctcggacgg ctgtctgaaa 1194481 ggtttgacag ccgttatttt ctgcttctga actcgtgggg gatggctgtt ctgcttttat 1194541 atgtcccgca tatcggaagc gtcgttcaag tgtatatcgt ccaagtgctg ttagggctct 1194601 ttggagcgat gcaaaagcat ggagaaaaag tgctgatcgc taattttaca gacagtggag 1194661 agcgtggaaa gaagatcggg aattaccatt tttggacagc tgtcttttca gcagcagcca 1194721 ttatgctcgg gggctttctc gctgactttt tcacagtgca aatgattttt tatgcaagct 1194781 ctattctata ttttttgagt ggattgatga tgatgaaaac aggctgacgc ggtcagcctg 1194841 tttttttatg cggctgaaat gcggcaccgc atcaacgttt ttgtgctgga gtcgtgctga 1194901 ttttttttga gcggaattcc cattgaacag aaaatttata aatgaataaa aatattaaat 1194961 atacgattga attaattttt attcatgtta taatgttaaa taatttcaca aagaccaaga 1195021 gggtgaactt gttttgaaaa taggaattgt aggtgctaca ggatatggag gcaccgaact 1195081 tgtcaggatt ctttcgcatc atcctcatgc agaggaatgc atactttatt catccagcgg 1195141 agaagggaat gtctatagcg agggttatcc tcatcttacc ggcttagcgg atcagcagct 1195201 gaagccgatt gatatgaata cgatcaaaca cgaaatagat atcatgtttc tcgctgcgcc 1195261 gcccggagta tcaagtgaat tgactccaaa gctggcagac gcgggaatta cggttattga 1195321 tctgtcaggt gatctgagga taaaagaacc ggctgaatat gaaaaatggt ataaacggac 1195381 agcggcaccg aaggcggtga ttcaagaggc ggtatacggt ctggcagaac tgaatcaact 1195441 gcaaattcaa caggcgaaac tcattgccaa tccaggctgt tttccaacag ctgttttgct 1195501 tggcctcgcg ccattggctc aaaagaaact gctcgatgaa tctttcgtta tcgttgacgc 1195561 gaagaccggt gtttccggag cgggaagaaa agcatccatg ggaactcatt tttctgagct 1195621 gaacgacaat tttaaaattt ataaagtcaa tgaacatcag cacacgccgg aaattgagca 1195681 ggcgctgaat gaatggcagc caggtctcgg gcccattaca ttttcggctc acttggttcc 1195741 gatgacaagg ggcatcatgg cgacgatgta taccagatta acctgtgacc taaccgcaga 1195801 tgacctgcat gatttatatt cggaatttta ccaagattca tattttgtga gagtgaggcc 1195861 aaaaggtcag tacccgcaaa cgaaagaagt gtacggcagc aatttctgtg atatcgccgt 1195921 gaccctcgat gagagaacga acagagtcac gatcgtctcg gtaatcgata atttaatgaa 1195981 gggtgccgcc ggtcaggcag tgcaaaactt taatttgatg aatggctgga atgaagaaac 1196041 tggactcacc atcacgccaa tttatccata gaacgggaga gaatcgaacc atgattcagt 1196101 taagtgaaga tcaaattgta aaagtaacag gtgatgtatc ctcgccaaaa gggtttcagg 1196161 caaagggtgt gcattgcgga ctgcgctact cgaaaaaaga cctcggcgtc attatcagcg 1196221 agacaccggc cgtgagtgca gcagtttata cccaaagcca ctttcaggct gctccgatca 1196281 aagtgacaca agacagctta aagcacggac cgacactgaa agccgtcatc gtcaacagcg 1196341 ccattgccaa cgcctgcacg ggagaacagg gcttaaagga cgcatacaca atgcgggaga 1196401 gctttgcttc acagcttggc attgagccgg agcttgtcgc tgtttcatca acgggtgtca 1196461 tcggcgagca tttagacatg gaaaaaatcc acgcggggat cgaactgctg aaagaaacac 1196521 ctgcgggatc aggcgatttt gaggaagcga ttttaacaac tgatacggtg atcaagcaga 1196581 cgtgctatga actggcaatc ggcggcaaaa cagtcacgat cggcggagcg gccaaaggct 1196641 ctgggatgat acacccgaac atggccacga tgctgggatt tgtgacaact gacgcggcaa 1196701 tcgaagaaaa agcgctgcaa aaggcgcttc gggaaatcac tgacgtttca tttaaccaaa 1196761 tcacagttga cggagaaaca tccacgaacg acatggtatt agttatggcg aatggctgcg 1196821 ccgaaaacga gtgcctgaca gaagaccatc cagactggcc ggtctttaaa aaagcgctct 1196881 tgctcacttg tgaggatcta gctaaagaga ttgccagaga cggagaaggc gcgacaaaac 1196941 taattgaagc ccaagtacag ggagcgaaaa acaatcttga tgcaaacgtc attgccaaaa 1197001 agattgtcgg ctcaaatctt gtaaaaacgg cagtatacgg aacagatgcc aactgggggc 1197061 ggatcatcgg agccatcgga cactccgcag cacaggtgac ggcagaagaa gtagaggttt 1197121 atcttggcgg ccaatgcctg tttaagaata acgaacctca gccattctct gaatctatcg 1197181 ccaaggaata ccttgaagga gatgaaatca ccattgtcat caagatggct gaaggggacg 1197241 gaaacgggag agcgtggggc tgtgacctga cctatgacta tatcaaaatt aacgcgagct 1197301 atcgcacgta ataaagggga gcgaaatgaa gaaaacaatc gtttttaaat gcgggggaag 1197361 cgtcatccgt gagctgtcgg aggaatttta tcaaaatctg aaagagctga gggcgtcagg 1197421 ctggaagctg gcaatcgtac atggcggggg accggaaatc acaaatatgc tgaaacggtt 1197481 aaatatcaag acagagtttt cgggcggaca gaggaaaaca acgaagccgg tgctggaagt 1197541 ggcggaaatg gttttatccg gttctgtcaa taaatttttc gttgctgagc ttgccaaaca 1197601 cggactgcga gccgcgggca tttctggtaa ggatggcggt cttttggagg ctgattatct 1197661 agatccggaa acatacggag aagtgggaga aatcaaaaaa gtcgatgcgt ccatggtgaa 1197721 cgcgctgatg gaaaatggca tcatccccgt tattgcgccg ctgtctatga caagcgactg 1197781 caaaacgctg aatgtaaatg ctgatctggc tgcttcagca gtcgccggag cgcttgaagc 1197841 cgataagctg atgttcgtca cggatgtcga tggaatcatg aaggaaaagc agcgtctgga 1197901 cgtcctgacc cctaaggaga ttcagatgct gatcaagcag gaagtgatca caggagggat 1197961 gatcccgaag gtcaattcag ccttgtcagc tttatcagat caggtgtctg aagtcatgat 1198021 cgtaaacggt aaaggatcat tcttcgcaga acaaaccttt caagggacaa aaattgtcaa 1198081 agcaaaggag gctgtttcat gagcagcttg tttcaaacct acggccgttg ggatattgac 1198141 atcaaaaaag caaagggaac gtacgttgag gatcaaaacg gcaaaacgta ccttgatttc 1198201 attcagggga ttgcggtatc aaatctagga cactgccatg aagcggtgac agaggcagtc 1198261 aaaaaacagc ttgacagcgt atggcacgta tccaacctgt ttcaaaacag tctccaagag 1198321 caagcggcgc agaagctggc agcgcatagt gcgggagatc ttgtcttttt ctgcaacagc 1198381 ggcgcggagg cgaatgaagg tgcgataaag cttgccagaa aagcaactgg aaaaacaaaa 1198441 atcatcactt ttcttcagtc gttccatggc cgcacgtatg cagggatggc tgcgaccgga 1198501 caggataaaa tcaaaacagg cttcggcccg atgcttggag gctttcacta cctgccatac 1198561 aatgatcctt ctgcttttaa agctcttggg gaggaaggcg atattgccgc ggtgatgctt 1198621 gaaacagtgc agggagaagg aggagtcaat ccggcgagtg ctgaattttt atcagccgta 1198681 cagtcgtttt gcaaggaaaa gcaagccctt ctcattattg atgaaatcca gaccggcatc 1198741 ggacggacgg gaaaaggctt cgcatatgag cacttcggac tctcaccgga tatcatcaca 1198801 gtcgccaaag gattgggaaa cggctttccg gtcggcgctg tcatcggaaa gaaacagctt 1198861 ggagaagcgt ttacccctgg ttctcacgga acgactttcg gaggaaacat gctggcgatg 1198921 gctgctgtga atgccacatt gcaaattgta ttccagcctg actttttgca agaggctgct 1198981 gacaaagggg cgtttttaaa agaacagctt gaggcagagc taaagagccc ttttgttaaa 1199041 caaatccgag gtaaaggatt aatgcttgga attgagtgtg atggcccggt tgctgacatt 1199101 attgctgaat tgcagacatt aggcttgctt gtattgccgg ccggcccgaa cgtgattcgg 1199161 ctgctgccgc cgctcaccgt gactaaggat gaaatagcag aagccgtcag caagctgaaa 1199221 caggcaatcg ctcatcattc cgctgtaaac cagtgatttt ttttcgatat aaaggcataa 1199281 aaattcattt ttataattaa ttattcatca agaggtgggc tgttagatgg aaggttattt 1199341 agtgttagaa gatgggacat cgttcagcgg cgagctggac ggtcatgaaa actgcacggg 1199401 agaagctgtt tttttcacag gaatgacagg ctaccaggaa gtgctgacag atccatcata 1199461 taagggacag attattgtat ttacctaccc gctgattggc aactacggca taaatgaaaa 1199521 ggattttgaa agcaagaaac cgcaagtaaa agccgcggtt gtctatgagg cgtgtgatca 1199581 cttttctcat tatgaagcgg tatacagcct caaggagtat ctacagaaat ggaatattcc 1199641 gctgttaacc catgttgata cgagggctgt cgtgaagaaa atccgggcaa acgggacgat 1199701 gggtgcgaca gtcacagcct ctaaagaagg agctgagatt gcccttcaac cagagaatgt 1199761 ggcagagcag gcttccgccc aggaaatcag cacattcggc gacgggaata aacatatcgc 1199821 tctcattgat tttggctata aaaagtcaat cgcatcatca cttgtcaaac gaggctgcaa 1199881 ggttaccgtg gtgccatacc agcaaatgga ggccgtatac aacatcaaac ccgatggaat 1199941 tgtgctatcg aacggacctg gagatccgaa agccattcag ccatatttag gaaagatcaa 1200001 aagcatcatc agccgctttc cgactctagg catttgtctc ggacatcagc tgatcgcgct 1200061 cgcgtttgga gggaatactt ttaagctgcc attcgggcac aggggagcta atcatccggt 1200121 catcgaccgt aagacgaaac gggtctttat gacaagccaa aaccacagct atgtggttga 1200181 tgaacagtcg attaatgaag aagagctcac catcaggttt catcatgtca atgatacgtc 1200241 agttgaaggg cttgcccata aaaaactgcc tgtcatgagt gttcaattcc acccggaagc 1200301 ccatcccgga cctgcggaaa gcgaatggat ttttgatgat tatctaaaga atgtgatacc 1200361 agcaaggaga gaaatcgcgc atgcctaaag acaccagtat ttcaagcata ttagtaattg 1200421 gctcaggccc gatcatcatc gggcaggcgg cagaatttga ttattcaggc actcaagggt 1200481 gcatcgcgct gaaggaggag ggctaccggg taattctcgt caacagcaat ccggcgacaa 1200541 ttatgactga tgaagccttc gctgatgaaa tttattttga gcctctgaca gcagaaagcc 1200601 tgacagccat cattaagaaa gaacggcctg atgggcttct tgccaattta ggcggtcaga 1200661 ccgcgttgaa tttagcggtg gagcttgaag aaacgggtgt tttaaaagag cacggcgtca 1200721 aactcctcgg cacatccgtt gaaacgatac aaaaaggaga ggaccgggaa aaattccgtt 1200781 cgttaatgaa tgaattaaaa cagcctgtgc cggagagtga aattgttgat aacgaggccg 1200841 atgccctcca ttttgcggaa tccatcggtt ttcctgttat tatcagacca gcttacacat 1200901 taggcggaaa gggcggagga atcgcccctg ataaagaagc ctttacagct atgattaagc 1200961 aggcgctatt agcaagcccg atcaatcaat gccttgtcga aaaaagcatt gccggcttta 1201021 aagaaattga atatgaagtc atgcgtgaca gcaataacac atgcattacc gtctgcaata 1201081 tggaaaatat cgatccggtc ggcgtgcata caggtgactc tatcgttgtg gcgccgtcac 1201141 aaacattgac agacgaagac tatcaaatgc tgcggacagc aagtctgacg atcatctcag 1201201 cacttgatgt tgtaggcggc tgcaacattc aattcgcgct tgatccattc agcaagcaat 1201261 attacgtcat tgaagtgaat ccgcgtgtaa gccggtcatc ggctctcgca tctaaagcga 1201321 ccggttatcc gattgcgaag atggccgcga aactggcagt cggatacact cttgacgagc 1201381 tgaaaaatcc gctcacaggc tcgacttacg caagctttga accggcactg gattatgtga 1201441 tcgtcaaatt tccgcgctgg ccgtttgata aattcaaaaa cgcagaccgc aagcttggca 1201501 caaaaatgaa agccaccggt gaagtgatgg cgattgaacg gaatttagaa gcggcgatac 1201561 aaaaggcagc cgcgtcgctt gaattaaaaa atatcgggac acaccttcca gagctcagcg 1201621 ggttgtcaat tgatacgcta tgggatttgg caatcactcc ggatgaccgc agatttttcg 1201681 ttgtcatgga gctgttgagc cgcagcgtct cgattgatga catccatgaa aaaacaaaaa 1201741 ttgatccgtt tttccttcat acctttgaca acatcatcaa attggaaaac cgcctgatgg 1201801 aagcagggag cgatctctct tttgaattat tgaagaaagc aaaggaaaag ggattctcag 1201861 acgcaacgat tgcctcgctg atcagcaaaa cagaagaaga ggtgcgcgcg cttcgcaagg 1201921 agatgggcat tacgccttcc tttaaaatcg tagatacatg cgcggcagag tttgatgcga 1201981 aaacaaacta tttttactcc acatatttcg gagagaccga tggagacatc agccgcaaag 1202041 agaaaaaacg cgcgctcatt atcggatcag gcccgattcg gatcggccaa ggcgttgaat 1202101 ttgattacag tgctgttcac ggtgtgctga cactgcaaga gcttgggttc gaaaccatca 1202161 tgattaacaa taacccggaa actgtcagca ccgattatga aattgcggac cgcctgtatt 1202221 ttgaaccgat gacaacggag catattgtaa acgtggcgga gcaggaaaat attgattttg 1202281 caattgtgca atttggcggt caaactgcaa tcaatgctgc tgaagcgctc gaaaaagccg 1202341 gcattactct tcttggcaca tcatttcaaa cgctcgacgt gttagaggat cgggatcaat 1202401 tttatcagct tcttgacgag ctgggattga agcacgcaaa aggagaaatt gcttatacaa 1202461 aagaagaagc cgcttcaaaa gcgagtgaga tcggctatcc ggtgttaatc cgcccatctt 1202521 acgttatcgg cggaatgggc atgatcattg ttgactcgca agcccagctt tctcagctgc 1202581 tgaatgatga ggacagcatg ccatacccga ttttaattga tcagtatgtg tctggaaagg 1202641 aagtcgaaat tgatttgatt tccgacggcg aggaagtctt tatcccgaca tataccgagc 1202701 atattgaacg ggcaggtgtc cattcagggg acagttttgc cattcttccc ggaccgtcca 1202761 tcacgagcgg gctgcagcag ggcatgaaag atgcggcaca aaaaattgcc cgaaaacttt 1202821 catttaaagg catcatgaac attcaatttg tgatcgacaa tggaaacata ctcgttcttg 1202881 aagtgaatcc gagagcgagc cgcacggttc ctgtcgtcag caaagtaatg ggcgttccga 1202941 tgattccgct cgccacacgt ctgctggcgg gagcgtcctt aaaagatcta aatccggcag 1203001 ttcaaaatca tcatggagtt gccgtgaagt tccctgtttt ttcttctcat gcgatccagg 1203061 atgtggatgt caagcttgga ccggaaatga aatcaacggg agaaggcatg tgtgtcgcat 1203121 atgattctaa cagcgccttg aaaaaaatct atacaagagt ctggagtcaa aaaggaagca 1203181 tttatttgca aaacgttccg gaagatgtga aggagttagc agaaaacgca ggttttacaa 1203241 tacatgaagg aacatttgcc tcatggatgg aacaggaagg aaactcgctc cacattaatc 1203301 tgagcggttc tgaagaagca cgcaaagaac gtttggaagc catgacgcac ggcatccccg 1203361 tctttacaga agaagaaact gtgcgggcgt ttttacaaag cggttcaggc catccgcagc 1203421 ctgtatctct caaagacctc tataaaaagg aagtggcatc atgcacacag tgacgcaaac 1203481 cagtttatac ggaaaagatt tattaacgtt aaaggacctt agtgaagaag atataaacgc 1203541 cttgctcgca gaagccggtg agctgaaaca aaacaaaatt cagcctatat tccatggcaa 1203601 aaccttggcg atgatttttg aaaaatcatc aacgcggacc cgtgtttcat ttgaagcggg 1203661 catggcgcag ctgggcggga gcgccctctt tctaagccag aaagatctgc agctggggcg 1203721 cggtgagact gtcgctgata cggcaaaagt gctgtcaggc tatgtggatg ccatcatgat 1203781 ccggaccttt gaacatgaaa aggtggagga acttgccaaa gaagctgaca ttccggtgat 1203841 caatggactt accgataaat accacccatg ccaggcgctg gcggatctct tgacgattaa 1203901 ggagataaaa gggaagctta aaggcgtaaa agtcgcgtac atcggtgacg gaaataacgt 1203961 ggcgcactcc ttgatgatcg gctgcgcgaa aatgggctgt gatatctcga tcgcttcacc 1204021 aaagggatat gaagtgttag atgaagcagc tgaagcggca aagacatatg cacttcaatc 1204081 cggctcttct gtcacgctga cagatgatcc gattgaagct gtaaaagacg cggacgtgat 1204141 ttattctgat gtgtttacaa gcatggggca ggaagcggaa gagcaagaac gtcttgctgt 1204201 ctttgcgcct tatcaggtga atgcggcgct ggtcagccat gccaagcctg actatacatt 1204261 tttacattgt ctccctgcgc atcgcgagga agaagtgact gcggagatta ttgacgggcc 1204321 gaactctgca gtgttccagc aggcggaaaa ccgtcttcat gtgcaaaaag cactgctgaa 1204381 ggccatttta tataaagggg aatcatcaaa aaactgctga gccaaactca gcagtttttt 1204441 tgatggcaac atattcacag ccgcttaggc gcatactaca gcaaaaagga aaaggaggaa 1204501 aaacagtggg acagcagcac caattccggc ccggacagaa agcgcctaat aacggtgtct 1204561 acgtagaaat cggcgagaca gggagcatgg ttaaaaaccc tcaaaaggtc catctgtcag 1204621 caggggaaat gttccccgaa acatcaaacc acaaccggct gtggacctac aaaagaaagc 1204681 cgtgaccact aaaaaaccca aaacaataaa tgttttgggt ttttggcttt ttaatgctgg 1204741 cttgcatttt tgttcatagg catgatttct gctaaaacca tgattaagac atacagtaca 1204801 acagcaatga cagatgatgt tttgaaatta tacgtaacgc tgttcatgct tgcaaccaag 1204861 tagcatgcca tatgtgataa aaggaacgtc caaataaagg caataatata tcgcacgttt 1204921 ccacctcgtc cttctcattc tattctaaaa gttatcatac catacaaaaa gcgaaggggg 1204981 aatccaattt tagcagaaag tgaggtgaca aaagagtctg attcgtcaca ctttaatggt 1205041 aaaatataaa acgtcaatca gtataatagc caaaaatgta aaaggctagg actttacctt 1205101 attcgtttct tttctattta cataagatag cgtgagatga agtgtgaaag gaggcgggca 1205161 agcgatggga ataacggaaa gatactttca actgggaacg gagcataatg tcattcatct 1205221 gccctatcgc ccgaacggct tcggcatctt tatcttgggg gacagaaccc actttgtcgg 1205281 acatgattca agcttttggc agcagcatta tggcagaaat cagcttctga gcatgttgat 1205341 gaatgaagga tacactcttt ttaacagcaa tctgttcgga aggcattggg gggcggaaaa 1205401 agcagtcacc tatgccaaac agctgataca ttctgtgctg aagcaggaaa tcctcaatcc 1205461 gaagattcat attttagcag aaggcatggg tgctctcgtg gccgatgaac tgcttcgttt 1205521 ttccccggat catatccgct cagccgcaat gttgaatcct tgtctcgatc ttcaggcaca 1205581 ttatgaatcg gaaaaagaaa ataaattttt ctataagcaa tttttgaaag aagtatcgaa 1205641 aagctacgga atttctgaaa aagaagcgga agcgattcgt tataaaacaa ttcaaagcta 1205701 cccgagcggc gtaccggttc atatatggca gcgtatgacc ggagctccat atccctacag 1205761 cgtacatgcg gaagttttca aggaaaaaca gcaaaagcaa ggctcaccgg tcgacatgac 1205821 atttcattta tttgagcatc caagcagaat ttatgcatca atttgcaaat tctttcatag 1205881 tcatgaaaaa gaattataga gaatataatg acaacagcct tctcttttgc ggaggctgtt 1205941 ttgttttggg aaatgaaaaa ccggaagggc ggcagatgca atggaatcaa cgctgattgt 1206001 aggtgcggac gaatttttcg gcctttcatt atgtgagcga atgatggatg aaggcataca 1206061 tgttgacgtt gttctggcgg aaacagaaga taaaatgaga caaatgtact tagaagaaag 1206121 actcatgtgg cttgggagaa atgaactctt tcgccagctt gaacacattg gagaccaaaa 1206181 ttatgataca atttgtatcc agttcggaag ttttttgcct ttagaccaat atgattctcc 1206241 ttatatttta gtatatgaag aagaccgaaa agaatgggat aaacgtgaaa aaacaggctc 1206301 ggaaaaaacc gtgatcctgc cgaaaatgta cgggccatgg aaagaagaaa cagaggaaga 1206361 cggctattac acaaacgacg tggctgacga gttgctgaga ttcctgttag aaccaagccg 1206421 tcatagcaaa gatcagcttt ttgaattgca agtcacagag aaaacctcaa aagaagaagc 1206481 aaaaacaaaa attatcgagt ggaaaagaca attttcatca attttcgaca aatattaaga 1206541 aaaaccttcc atgtttcgag ttttctagat acaataaacg tataaaaata atacatgtta 1206601 tagcttgtca aaaggagttg aacatgactt gatcacaagg cttgtcatga tcttttctgt 1206661 cctcctttta ttgagtggat gtggacaaac tccgttcaaa ggaaaaattg agaaggtcgg 1206721 catgctcttt cctgatacga ttaatgacct cgtatggggc acaaaagggt ataaaggatt 1206781 actgaatata caatccaaat acaatgtgga cgtctattat aaagaaggcg ttaaaacaga 1206841 agaagatatc ataaatgcga ttgaggattt tcataagagg ggcgtcaatc tgctctacgg 1206901 ccatgggagt gaatatgctg aggtgtttaa cttggtcggc gaagattatc cagatatgga 1206961 attcgtcatt tccaatgcga aagcgaaagc tgataatgta acaagtgtcc attttagcgg 1207021 ggaagcaatg ggcttttttg gaggaatgac tgctgcccat atgtcgaaaa cgaatcaggt 1207081 cggtgtaatt gcttccttta cgtggcagcc tgaggttgac ggttttatca aaggggccaa 1207141 gtatgaaaat ccggatatag aggtaaatac gaaatatacg gatcattggg atgatgatac 1207201 aacagcagta aagctttatc agaaaatgaa gaacgaaggc gcggatgttg tgtatcccgc 1207261 cggagacggg tataatgttc ctgttattca gcaaatcaaa aaagacggtc tttatgccat 1207321 aggctacgtc acagatcaat cggatctggg cgagaatacc gtattaacca gcacggtgca 1207381 aaatgtggac aaggcctatg aaatcattgc tgaacaattt aataaaggca cccttgaggg 1207441 cggcgatcat tactacgacc tgaacacggg agtcgttgag atgggaacat tcagcccgct 1207501 cgtcgatcaa gactttcagc aaagaatcgc caagctgatc aaaacataca acaaaacagg 1207561 cgagctgcca aaaaacgagt aatggagtga cgtcacatgc agcacgaaaa atcacttgaa 1207621 ttcttgcaaa ttgccatgaa atatctccct gaagcgaaag aacagcttga gaaatcaggc 1207681 attgagctct caatggaggc catccagccg tttatgaatc tatttacaac ggtaatggcg 1207741 gaagcttatg agcttggcaa gtctgacgct aaatctgaaa cagaataaga agaagccact 1207801 tttttgaaag tggcttttca catgattttc tttttaatag cggagagcat gggcgcaagc 1207861 tcctttaaag cgggcttgat ttgatcaaga gagttcataa ttgaaccgat ttggtccata 1207921 atatgcatgt aattaatcgt ctcttcgtcg tttgtctgag aaacctgaga aacttcctct 1207981 tgctgttcct cctccttctc ttctgttggt tttgctgcat cgccgaacat cattcttgaa 1208041 aacacatcca actgcatacg cctcctttcc atataccata ctctatgagt aagatgaact 1208101 gatagtttag acgaatatat tgccatgtga aaaaaaatag gatagaatta gtacctgata 1208161 ctaataattg atcacaacct gattgatctt ctaaatttaa gatataaagg agtcttccct 1208221 aatgaaagct ggaatacttg gtgttggacg ttacattcct gagaaggttt taacaaatca 1208281 tgatcttgaa aaaatggttg aaacttctga cgagtggatt cgtacaagaa caggaataga 1208341 agaaagaaga atcgcagcag atgatgtgtt ttcatcacat atggctgttg cagcagcgaa 1208401 aaatgcgctg gaacaagctg aagtggctgc tgaggatctg gatatgatct tggttgcaac 1208461 tgttacacct gatcagtcat tccctacggt ctcttgtatg attcaagaac aactcggcgc 1208521 gaagaaagcg tgtgctatgg atatcagcgc ggcttgtgcg ggcttcatgt acggggttgt 1208581 aaccggtaaa caatttattg aatccggaac ctacaagcat gttctagttg ttggtgtaga 1208641 gaagctctca agcattaccg actgggaaga ccgcaataca gccgttctgt ttggagacgg 1208701 agcaggcgct gcggtagtcg ggccagtcag tgatgacaga ggaatccttt catttgaact 1208761 aggagccgac ggcacaggcg gtcagcactt gtatctgaat gaaaaacgac atacaatcat 1208821 gaatggacga gaagttttca aatttgcagt ccgccaaatg ggagaatcat gcgtaaatgt 1208881 cattgaaaaa gccggacttt caaaagagga tgtcgacttt ttgattccgc atcaggcgaa 1208941 catccgtatc atggaagctg ctcgcgagcg tttagagctt cctgtcgaaa agatgtctaa 1209001 aactgttcat aaatatggaa atacttctgc cgcatccatt ccgatctctc ttgtagaaga 1209061 attggaagcc ggtaaaatca aagacggcga tgtggtcgtt atggtagggt tcggcggagg 1209121 actaacatgg ggcgccattg caatccgctg gggccgataa aaaaaggtga ggtgcacaca 1209181 agatgactaa aaaaagagta gttgttacag gacttggagc attatctcca cttggcaacg 1209241 acgtcgatac aagttggaat aacgcaatca acggtgtgtc cggaatcggt ccgatcactc 1209301 gtgttgacgc tgaagaatat ccggcaaaag ttgccgctga attaaaagat tttaatgttg 1209361 aagattatat ggataaaaaa gaagccagaa aaatggaccg ctttacacaa tatgcggttg 1209421 tggctgcgaa aatggcggtt gaagatgcag atcttaacat taccgatgag atcgcgccga 1209481 gagtcggtgt ttgggtaggc tccggtatcg gaggacttga aacactagag tctcaatttg 1209541 aaatcttctt aacaaaaggc ccaagacggg taagcccgtt tttcgtgcca atgatgattc 1209601 ctgacatggc gacaggccag atttctattg cattaggagc aaaaggggtg aactcttgta 1209661 cggttacagc atgtgctaca ggaacgaact ccatcggtga cgcgtttaag gttattcagc 1209721 gcggtgatgc agacgtgatg gtcacaggcg gaacagaagc gccgctgaca agaatgtcat 1209781 tcgccggctt tagtgccaac aaagcgctgt ctactaatcc agatccgaaa acagcgagcc 1209841 gcccgtttga taaaaaccgt gatggctttg tcatggggga aggtgcaggg attatcgttc 1209901 ttgaagaact tgagcatgcc ctggcccgcg gcgctaaaat ttacggagaa attgtcggct 1209961 acggctcaac cggagacgct tatcatatca cagcgccggc ccaagacggt gaaggcggag 1210021 cgagagcgat gcaagaagcc attaaagatg caggcattgc acctgaagaa attgattaca 1210081 tcaatgctca cgggacaagc acgtattaca acgacaaata cgaaacaatg gcgattaaga 1210141 ccgtttttgg cgagcatgcg cataaacttg cggtaagctc tacaaaatcg atgacaggcc 1210201 acctcttagg agcagccggc ggtattgaag ccattttctc tatcctggcc attaaagaag 1210261 gcgtgattcc gccgacaatc aatattcaaa cacctgacga agaatgtgat ttggattatg 1210321 tgcctgatga agcccgcaga caggaactta attatgttct cagcaactca ttaggattcg 1210381 gcggacacaa cgcaacatta atctttaaaa aatatcaatc ataatcaagc caaaccggct 1210441 gcccttaaag ggtagccggt tttttttgtg tgcataggat taaaagagga ggcgatcaca 1210501 tgagtgtaga acaaacatat agctggctca ggaaggccgg ttcaatagat gatttggcgc 1210561 attacattat cccgcttttt tcaggtgcgg agaaaaagaa ctggaagggc attctggggc 1210621 atcttcagca tcatgggatg tttaaaaaca taaaagaggg tattcagacg gtttccaagc 1210681 tgaaggaaaa aggtttttac ggacatatcc aaaaggaaga acagtacctc aaaaacaaat 1210741 ggcaaggtcc tgatgtacca attgttacgc tgccggttga tgaacgaaac aggagaatcc 1210801 gtttagaatt cggatcaaaa tcaggactcg cctttcaaga caaaatgttc ctttttcttt 1210861 cgtcagattt agattttggg tcggtatctg cccttatgac gcatgagtat catcacgttt 1210921 gccggttagg tcatctgaca aaagaggaaa aggatgtcac attacttgat acaatcatca 1210981 tggaagggct ggcggaatat gctgtttatg agaggttcgg ccgaagtcaa acggctgaat 1211041 ggacgacttg gtatacaccg gaacagcttc aggctttata tgaaaaaaag attgcgcccc 1211101 atcgggatat caaacgggat aatcgattat ttccccagct gttattcggc aaaggatatc 1211161 agccaaaaat gcttggatac gcagttggat tcaatattgt aaaaaaatat ttaaccgcca 1211221 gcaaggcaag caccgcagac gggctgtcca ttcctgctga gacctttttg gatgcaatgc 1211281 tttaaaagga taaaataatg gaatttcatt aataatatta catttatcct aaaaaattct 1211341 tgattttgca aaatgattgt aataatatac aactataaaa tttttcgata attcaatatt 1211401 atttattatt tctgaataaa gggattgctt tctcttgaaa acgtttgaca acaagagggg 1211461 ggaaagggga gctagcatga gcacactttt agaagtgaat aatttaaaga cttatttttt 1211521 caggaaaaag gagccgatcc ctgcggttga cggagtcgat tttcacatca gcaaaggcga 1211581 aaccgtcgcg cttgtaggtg aatcgggctc cggaaaaagc attacttctt tatcaattat 1211641 gggcctcgtc caaagctcag gcggaaaaat catggacggc tctattaaac tcgaagacaa 1211701 agacctcacc tcattcactg aaaacgatta ttgcaaaatc cgcggtaacg aagtatccat 1211761 gatctttcag gaaccaatga cctcccttaa tccggtgtta acaatcggag aacaaattac 1211821 cgaagtgctg atttaccata aaaacatgaa gaaaaaagaa gcccgtcaac gagctgttga 1211881 actcttgcag atggtcggtt tctcccgggc ggagcaaatt atgaaggagt acccgcatcg 1211941 gctgtccggc ggtatgagac agagggtgat gattgccatc gcactgagct gtaatcctaa 1212001 actgctcatt gctgatgaac caacgacagc gctggacgtg acaatacaag cccaggtgct 1212061 ggagctcatg aaagatctct gtcagaagtt caatacatcg attcttctca tcacacacga 1212121 cttaggtgtc gtgtctgaag ctgccgatag agtgattgtc atgtactgcg gacaagtcgt 1212181 agaaaacgcc actgttgatg acttattttt agaaccgctt catccgtata cagaaggcct 1212241 gcttacgtca attcctgtta tagatggaga gattgataaa ttaaatgcga ttaaaggcag 1212301 tgtgcctaca ccggataatc tgccgccggg gtgccgtttt gccccaaggt gcccgaaagc 1212361 tatggataag tgctggacaa atcagccttc gcttttgaca cacaaaagcg gaagaacggt 1212421 gagatgcttt ttatatgagg aagagggtgc cgaacaatca tgacagcagc taatcaagaa 1212481 acaatcttag agcttcgtga cgtaaaaaaa tactttccga tccggtcagg cctttttcaa 1212541 agaaaagtcg gtgatgtaaa agcggtggat ggtgtttcat tttcgttaaa aaaaggagaa 1212601 acactcggaa tcgttggaga gtcgggctgc ggaaaatcga ctgccggcag aacgatgatc 1212661 agactgtaca aaccgacaga gggccaaatt ctttttaaag ggcaggatat ttccaatctg 1212721 tcagaggaga agctgcggaa gagtgtccgc aaaaatattc aaatggtttt ccaagatcca 1212781 tttgcttcgt taaacccgag aaagaccctg cgttccatca taaaggagcc gtttaatacg 1212841 cacaacatgt ataccatgcg tgaacgaaac gaaaaagttg aagagctgct tgcaagagta 1212901 gggcttcacc cgtcgtttgc cggccgttat ccccatgagt tttcaggcgg ccagcgtcag 1212961 cggatcggca ttgccagagc actcactttg aatccagagc tgatcattgc agatgagccg 1213021 gtttccgcac ttgatgtatc cattcaggcc caagtgatta acttgatgga ggaattacag 1213081 gaagaattta atcttacgta tctatttatc tctcatgatc tgagtgtcgt ccgccatatc 1213141 agcgacagag tcggagtaat gtatcttggc aaaatgatgg aactgaccgg caagcatgag 1213201 ctttatgaca acccgcttca cccatatacc caagcgcttt tatcctccgt tccggttaca 1213261 agaaaaagag gttctgtcaa acgtgaacgc attgtcctga agggagaact gcctagtccg 1213321 gccaacccgc caaaaggctg cgtattccac acaagatgtc ctgttgcaaa accgatatgc 1213381 aaggaacaaa taccagaatt taaagaagct gctcccagcc actttgtggc ttgtcacctt 1213441 tatagctaat gttgcccgca cagctttgag agggggtatg cacactacat aaacaacagc 1213501 ctagaagaac gaacatttca agagggggaa tatctaatga aaagacggaa aaccgcactg 1213561 atgatgctaa gtgtattgat ggttctggcc atctttttat cagcctgctc gggatcaaaa 1213621 tcaagcaaca gcagcgcgaa aaaatcagca ggcaaaccgc agcaaggcgg ggatttggtt 1213681 gttggttcaa tcggagaacc cacacttttt aactctctgt attctaccga tgacgcaagt 1213741 acggatattg aaaatatgct gtacagcttt ttaacgaaaa cggatgaaaa actaaatgtg 1213801 aaattgtcac tcgctgaaag cattaaagaa ttagacggcg gccttgcata tgatgtgaaa 1213861 attaaaaaag gcgttaagtt tcatgacgga aaagaactga ctgcagacga cgtcgtattt 1213921 acgtacagtg tccctttaag caaagattac aagggagaac gcggttcaac atatgaaatg 1213981 ctgaaatccg tagaaaaaaa ggcgattacg aagtcttgtt taagctgaaa tataaagacg 1214041 gtaatttcta caacaatgcg ttagacagca cagctattct gccgaaacat attctcggta 1214101 atgttccgat tgctgattta gaagaaaatg agtttaacag aaagaaacca atcggttcag 1214161 gaccatttaa gtttaaggaa tggaagcagg gccaatatat taagctcgaa gcgaatgatg 1214221 attactttga aggaagaccg tatttagata ctgtgacgta taaagtcatt cctgacgcaa 1214281 atgctgccgt tgctcagctg caggcaggcg atattaattt ctttaatgtg cccgccactg 1214341 actacaaaac ggctgaaaaa ttcaacaacc taaaaatcgt tactgatttg gcattaagtt 1214401 atgtgtacat cgggtggaat gaaaaaaatg aattattcaa ggataaaaag gttcgtcaag 1214461 cgctaacaac cgctcttgac cgcgagtcaa tcgtcagcca agtattagat ggagacggcg 1214521 aggtagctta cattccggaa agccctttat cttggaacta tcctaaagat atagatgttc 1214581 cgaaatttga gtacaacgag aaaaaagcga aacagatgct tgcagaagcc ggctggaaag 1214641 atacgaacgg tgacggcatt ctggataaag acggaaagaa attctcgttt acccttaaaa 1214701 cgaaccaagg aaacaaagtc cgtgaagaca tcgctgtcgt cgttcaggaa cagctgaaaa 1214761 aaatcggcat tgaagtgaaa acccagatcg ttgaatggag cgctctcgtt gaacaaatga 1214821 atcctccgaa ttgggatttt gatgcaatgg tcatgggatg gagtttatcc acattcccgg 1214881 atcaatatga tattttccat tcaagccaga ttaaaaaggg tttgaactac gtttggtata 1214941 aaaatgccga agcggataaa ctcatgaaag atgcaaaatc aatcagtgac agaaagcagt 1215001 attcaaaaga atatgagcaa atctatcaaa aaattgcgga agatcagccg tatacgttct 1215061 tgtattatcc taacaaccat atggcaatgc cggaaaatct tgaaggatac aaatatcatc 1215121 cgaaacgtga tttgtataat attgaaaaat ggtggcttgc aaaataaatt tcccttaaag 1215181 gggagggaga gcgttttctc cctcttctgt ttttaataag gaaagtaaag ggggacaagt 1215241 atatggctgc atatattatc agaagaacct taatgtctat cccgatttta ttgggaatta 1215301 cgattttatc atttgttatc atgaaagccg cgcccggaga tccgatgaca ttaatgatgg 1215361 acccgaaaat cagccaggct gacagagagc agtttattga aaaatacggt ctgaatgatc 1215421 ctcagtacgt tcaatattta aagtggctag gcaacatggt gcagggtgat ttcggaacgt 1215481 ctattgtcag aaaaggaacg cctgtttcag aattgattat ggcaagacta cccaatacgc 1215541 tcctgctgat gctggtttca acgattttgg ctcttatgat ttctattccg ttcggtgtcc 1215601 tgtcggcaaa gcggccgtat tcaaaaatcg actatggcat tacatttacc tcgtttatag 1215661 gcctggctat tccaaacttt tggtttggat taattttgat tatggtgtta tcggtaaatc 1215721 tcggctggtt tccaactggg ggtgtcgaga cactgaatac cgaattcaat atatttgacc 1215781 ggattcatca tttaattctg cctgcattcg ttctagctac agctgacatg gccggactga 1215841 cgagatacac gagatccaat atgcttgatg tattaaatca agattatatt cgcacagcga 1215901 gagcaaaagg atttaaagag aacagagtgc tatttaaaca tggattgagg aatgcattat 1215961 tacccgtcat tacaattttc ggtttgatga ttccttcatt tatcggcgga tctgtcgttg 1216021 tcgaacaaat tttcacttgg ccgggattag gaaagctgtt tgtcgattca gcattccagc 1216081 gcgattatcc ggttatcatg gcaatgactg tgatctcggc ggttcttgtc gttgtcggaa 1216141 acctcattgc agacatcctt tacgcgattg ttgatccgcg gatcgaatat taaaaggagg 1216201 gaaacagaga tgtcagagct gcaaacaact ccctcgccgg agatcaggct gaaagaaaat 1216261 atttcgaaaa agccagaaac aatgacaaag attttctggg aaaaattctc gaaaaacaaa 1216321 ctggccattt taggtgccgt tattcttttt atcattatta tgtctgctgt tttcgcccct 1216381 ttaattgcac cttatcccca agagcagcaa agcctgcttg ataaatataa ggcgccgggc 1216441 cttgaacatc tgatgggaac ggataaattt ggacgtgata ttttcagccg gatcctatat 1216501 ggagcgcgtg tctctttatt ggttggattt gcgtccgtag tcggttcgat tttgatcgga 1216561 acggttttag gagcattagc cggatatttc agaggaatag tggatgctgt cattatgcgt 1216621 gtagttgaca ttgtgttatc cattcctgat attttcttgt tgatcacgct ggtcaccatc 1216681 ttcaagccgg gtgtggacaa attgatttta attttctgtc tcacaggatg gaccacaaca 1216741 gcacgattag taaggggaga attcttgtcg ctccgttcaa gggaatatgt tcttgctgct 1216801 aaaacaattg gaacaaaaac gcacaaaatt attttttctc atatcctgcc caatgcgtta 1216861 gggccgatta tcgtgtcagc tacgctgaaa gttgggtctg ttattctagc tgaatcggcg 1216921 ctaagctact tgggctttgg aatccagccg ccaatcgcta gctgggggaa catgcttcaa 1216981 gacgcacaga atttcacagt aatgattcaa gcatggtggt acccgttatt tcccgggcta 1217041 tttattttaa tgaccgtttt atgcttcaac tttgtcggtg atggcctgcg ggatgcgctt 1217101 gacccgaaaa atattaaata aaaatgaata tcatatctgt tataaaatat caccaaatca 1217161 gaaaaaagca ggtctccttt agtcagaaaa tatacaaaga gatctgcttt ttatgattct 1217221 tacataaacc cagtgattcc agatttcctc aatctctttg gaataatttc tctatccctt 1217281 gcctatactg tggacaacag tttttataaa agtgaggggt tagagatgtt atttcttcat 1217341 gatgtgtggg tcaattggtt tgaaggggaa gaaaatggct acaatgtatg ccactttcac 1217401 gaatggcgca aggaagatac ggttgagctt ttggatcagg tgccgctgtt aagggtgccg 1217461 tcagtactgt ttcattacat agaaaacgat ttgtcagagc ttccgaaagg tttgcttgaa 1217521 gacgtacatc agaaatcgta cattcgaaaa aatcatgagc ggacaaagct tgagtattgt 1217581 tttgtcgtaa cagacggaat cggcatttta gctgttgaca cgatcggcta cacgatccct 1217641 gtcagaaaaa gccgtctaat cccaagacag gagcagctcg tttatgaaat ggtaaaagat 1217701 gtagagcctg aaacatatga atttgagcca aagaagctgg aatcctccaa ggaatatcac 1217761 atcttatcat tagcaccaga acatgtcaga ggactgacaa gaaaagaacg gcaaattaag 1217821 cagctgatgt ttatggcgct tgaccaatta aaagggctga aaaaccgagc ggaaattggc 1217881 tactggtaca cagagtggaa tccgcatatg tatgaacaaa tcaaaaggat gagctttgaa 1217941 gagatttggg acatgctgta taacgaaaca attgaaggct ggtcggacaa acacctagct 1218001 ttttgcgaaa acctaataaa aggacagcct tttttcgaaa agctttggga aatggaaaac 1218061 gaatcaaagg tcaactgaaa aaaaccgctc tttgcaaaga gcggtttttt gattagcgtc 1218121 tttttcttcc aagacccatg gcattctcca tttttttcag cattttgttt gctgtccgat 1218181 tcgctcgttc cgcgccttca tcaagaatcc ggtctaattc ttcagattct atcagctcgt 1218241 aatagcggtc ctggatcggt tttaatgcgt tcactacgac ttctgccaaa tcacctttaa 1218301 actcgccgta gccttttcct tcgtactttg cttcaagctc ttcaattgtc gtattgccga 1218361 ggattgaata aattgtaaga aggttggaaa cgcccggttt gttttcctta tcaaatttga 1218421 caatgccttc agaatccgtt actgcgcttt tgattttctt ttcaagctgc ttcggctcat 1218481 ccagcaatgt aatataagct ttctgattcg gatcagattt gctcattttc ttcagcggat 1218541 cattcagaga catgatacgt gcaccgactt ttggaatttt cacttccgga atcgtaaaga 1218601 tgtcgttgta ttttttgttg aagcgttctg caagattccg cgtcagctca aggtgctgct 1218661 tttgatcctc gccgacaggt acaagatccg ttccgtacag cagaatatca gcggccatca 1218721 gcggcggata tgttaacagg ccggagacga cagcttcatt gcctttggat ttgtccttaa 1218781 attgagtcat ccgctcaagc tcgccgatat aggcgacaca ctgcatcatc catccggcct 1218841 gcgcatgtgc ggggacctct gactgaataa acaatgttgc tttttctgga tcaagtccga 1218901 cagctaagta aagcgccgcg agattgcgga tattctttct aagctcaagc cggtcttgag 1218961 gaacagttat cgcatgctga tcgacgatgc aaaaatagct gttataatca tgctgcagtt 1219021 cgacaaactg cttcattgca ccgatatagt tgccgagcgt cactgagccg cttggctgaa 1219081 tgcctgaaaa aatcgtttgt ttcatgaaaa catcaacctc atttcttaaa acataataaa 1219141 aaaggctcat tcttcccctg taaaaaaggg acgaatgaac cgtggtacca ccctgattat 1219201 tccattaaaa tggaatcact ctgacgtttg taacggagac tgctccggct gagcctactt 1219261 ttttccagtt cggtcagctg ctccaaagtc cattccacat tgcccgttat ctgctcccag 1219321 caccgcagac tctcttcaaa caggtgaaac gtgtactact ctttttcata gcaagctttt 1219381 cttttgattg cttcattata aatcaattat aaccaattgt catcatgaaa aaacattctt 1219441 ttttccagta aaattgtaat aatataaata acacgagtgc tgtaaaatcc ttaaatgata 1219501 actgctatca gcgtaaaaac aggcagatat tatatgtaaa aagcaatatg ggcagaaaac 1219561 acatgaaaaa gtttttaatc aatttatgct ttaaatggta gaaggatatt atgttcatgg 1219621 aagaaaaact aacgaagttt aaatatttta aattgataaa ataatattgc aataaattat 1219681 ttgtttcatt ataatgaact tgttcactct attgttacag cttttttaca aaaataatca 1219741 gaaaagacgg aacagaataa aagttgtgga aactcaggtt catttgtctg atatttctga 1219801 ggatttagcc gtaaggagct gaaaattatt attagggggt ttgcgaatat gaaaaaacgt 1219861 tggtcgattg tcacgttgat gctcattttc actctcgtgc tgagcgcgtg cggctttggc 1219921 ggcagcggat caaacggtga agggaaaaag gacagtaaag gaaagacgac acttaacatt 1219981 aatattaaaa ctgagccgtt ctccttacat ccgggattgg caaatgattc agtatcaggc 1220041 ggtgttatcc gtcagacttt tgaaggattg acacgtatca atgcagatgg tgagcctgaa 1220101 gaaggcatgg cttctaaaat tgaaacgagc aaggacggaa agacatatac atttaccatt 1220161 cgtgatggtg tgaaatggtc taatggagac cctgtaactg cacaagattt tgaatatgct 1220221 tggaaatggg cgcttgaccc taataatgaa tcacaatacg cttaccagct ctactacata 1220281 aaaggtgctg aagcggcgaa taccggaaaa ggcagcctag acgatgtggc agtaaaagct 1220341 gtgaatgaca aaacgctgaa ggttgaatta aataacccga ctccatattt cactgaatta 1220401 actgcgttct atacgtatat gccgatcaat aagaaaattg cagagaaaaa taaaaagtgg 1220461 aatacaaatg ccggagatga ttatgtatca aacgggccgt tcaaaatgac ggcatggaaa 1220521 cacagcggct ctattactct cgaaaaaaat gaccagtatt gggataaaga caaagtcaaa 1220581 ctgaagaaaa tcgatatggt tatgatcaac aataacaata cggaactaaa aaaattccaa 1220641 gctggcgaac ttgattgggc cggtatgccg ctcggacagc ttccgacaga atccctgccg 1220701 accctgaaaa aagacggttc tttacatgtt gagccgattg caggagtgta ttggtacaaa 1220761 ttcaacactg aagctaagcc attagacaac gtcaatatcc gtaaagcttt aacatattcg 1220821 cttgaccgtc agtcgattgt taaaaacgtt acgcaaggag agcaaatccc ggcaatggct 1220881 gcagtgccgc ctacaatgaa gggatttgag gataacaaag aaggatactt caaagacaat 1220941 gatgtcaaaa cagcaaaaga ataccttgaa aaaggcctaa aagaaatggg cttaagcaag 1221001 gcatctgatt tgccaaaaat caaattgtct tacaacactg atgacgcaca cgcgaaaatc 1221061 gctcaagcag tacaagaaat gtggaagaaa aatttaggcg ttgatgttga gcttgataac 1221121 tcagagtgga atgtctatat tgataagctc cacagccaag attatcaaat cggccgtatg 1221181 ggctggctcg gcgacttcaa tgatcctatc aacttccttg aattgttccg cgacaaaaac 1221241 ggaggaaata acgatacagg ctgggaaaat ccagaattca aaaagcttct gaatcagtca 1221301 caaactgaaa cagataaaac aaaacgtgca gagctgctga aaaaagcaga aggtattttc 1221361 attgatgaaa tgccggttgc cccaatctat ttctatactg atacttgggt acaggatgaa 1221421 aacctaaaag gtgttatcat gccaggtact ggtgaggttt atttcagaaa cgcatatttt 1221481 aaataaggct acgtctgaaa ataaaagacc tcaaggtata tggggagaaa agccccatat 1221541 acctttctta ctgatggagt ataaaaatgt aaaaaccatg gaggtgttcc cccttgctaa 1221601 aatatatcgg aagacgctta gtctatatga ttatcacact atttgtgatt gtaactgtga 1221661 cattcttctt aatgcaagca gcaccgggcg ggccattttc aggtgagaaa aagcttccgc 1221721 ctgaaattga agcaaattta aatgcgcatt atggcttgga caagccgctg tttgtacaat 1221781 atgtcagtta tttgaaatca gttgcaatgt gggatttcgg accgtcattt aaatataaag 1221841 gtcagagtgt taacgacctg atcagttcag gtttccccgt ttcatttact cttggagcag 1221901 aagctattct cctcgcttta gcgttaggtg tattgtttgg ggtcattgca gccctttacc 1221961 ataataagtg gcaggattat accgtcgcga ttttaacgat atttggtatt tcggttccga 1222021 gctttatcat ggcggctgtt ctgcaatatg tgttctccat gaagcttggg ctgtttccgg 1222081 tcgcggggtg ggattcctgg gcatacacct ttttgccttc catcgcactt gcttccatgc 1222141 cgatggcgtt tattgccaga ctttcccgtt caagcatgat cgaagtgtta aacagtgatt 1222201 atatccgcac agcgaaagcg aaagggcttt cccgcccagc ggttacagtg cggcacgcca 1222261 ttcgaaacgc acttttgccg gttgttacat atatgggccc gatggccgca caggtcttaa 1222321 cggggagctt cattattgaa accatttttg ggattccggg gcttggtgca cacttcgtca 1222381 acagtattac aaaccgtgat tatacggtca ttatgggtgt aacggtgttc ttcagtgtca 1222441 tcttgctatt gtgtgtatta atcgtagatg tgttatacgg cattattgat ccaagaatca 1222501 agctttccaa agcaaagaaa ggagcctagg ccatgcagaa cattccaaaa aacatgtttg 1222561 aaccagccgc agcgaatgcc ggcgatgcag aaaaaataag taaaaagagc ctttccctct 1222621 ggaaagatgc gatgcttcgc ttccgcagca ataagcttgc aatggtcggg cttatcatta 1222681 tcgtacttat tatccttatg gcaatttttg cgccgatgtt ctcaaggtat gattattcaa 1222741 ctactaatct cttaaatgcg gataagccgc cttcaaaaga tcactggttc ggaacagatg 1222801 atcttggacg ggacattttc gtccgtacat gggtaggggc gcgaatctca atctttatcg 1222861 gtgttgcagc tgctgttctc gatttgctga tcggcgtcat ttgggggagc atttcaggct 1222921 tccgcggagg aagaacagat gaaatcatga tgcgtatcgc tgatatcctt tgggcagttc 1222981 cttcattatt aatggttatc ttactgatgg ttgttcttcc gaaaggtcta tttacgatta 1223041 ttattgccat gacgattaca ggctggatta atatggccag aatcgtgcgc ggacaagtgc 1223101 tgcagctgaa gaatcaggag tatgtgcttg cttcacagac actgggtgca aaaacatccc 1223161 gtcttctatt taaacatatc gtgccaaacg caatgggttc tattttggtc acgatgacac 1223221 tgacagttcc tactgcgatt tttacagaag cctttttaag ctatttggga cttggtgttc 1223281 cggctccgct ggcaagctgg ggaacgatgg cttctgacgg attgcctgca ttgacctatt 1223341 atccgtggcg tttattcttc cctgccggat ttatctgcat tacaatgttt ggttttaacg 1223401 ttgtcggcga cggattaaga gacgcattgg atcctaagtt acgtaaataa gggagtgata 1223461 cgggtgacac gcctattaga agtaaaagat ttagcaattt catttaaaac atatggcgga 1223521 gaggtccagg cgatccgcgg agtgaatttc catctggata aaggggagac gctggccatt 1223581 gttggagaat caggttccgg aaaaagtgta acctctcaag cgattatgaa gctgattcca 1223641 atgcctccgg gttatttcaa acgcggtgag atcctgtttg aaggaaagga tctggtgccg 1223701 ctgtccgaaa aagaaatgca aaatgtccgg ggaaaagaga tcggcatgat attccaagat 1223761 ccgatgacct ctttaaatcc aacgatgaag gtcggtaaac aaattacgga agtgcttttt 1223821 aaacacgaaa agatctcgaa ggaagcggct aaaaaacgcg cggttgaact gctggaatta 1223881 gtcggtatcc caatgccgga aaagcgggtg aaccaatttc cgcatgaatt ttcaggcggg 1223941 atgagacaga gggttgtcat tgccatggcg cttgcagcga atccgaaact tctgatcgcc 1224001 gatgagccga caactgctct tgatgtaacg attcaagcgc aaattttgga attaatgaag 1224061 gatttgcaaa agaaaattga cacgtccatc atctttatca cacacgatct tggtgttgtg 1224121 gctaacgttg ctgaccgggt cgctgtcatg tacgcgggac agattgtaga aactggtacg 1224181 gtagacgaaa tcttctacga cccgagacat ccgtacactt gggggcttct tgcatccatg 1224241 ccgacactgg aaagttcagg agaggaagag ctgactgcaa ttccgggcac gccgcctgat 1224301 ttgacaaacc cgccaaaagg agatgctttt gccctgcgga gctcttacgc gatgaaaatc 1224361 gattttgaac aggagccgcc aatgtttaag gtatccgata ctcattatgt aaaatcgtgg 1224421 ctgcttcatc ctgacgcgcc aaaggtagag ccgcctgaag cggtaaaagc gaaaatgcgt 1224481 aaactggcaa acacgtttga aaaacctgtc ttagtgagag aagttgaatg aattgactga 1224541 aaaactatta gaaatcaaac atttaaaaca gcactttgtc acgccgaggg gaacggttaa 1224601 ggctgtagat gatttatcat ttgatatcta taaaggtgaa acattagggc tggttggtga 1224661 atctggctgc ggtaaatcga caacaggccg aagcattatc aggctgtacg aagcaaccga 1224721 tggtgaggtg ctgttcaacg gcgaaaatgt gcacgggaga aaatcgcgga aaaagctgct 1224781 ggaattcaac cgcaaaatgc agatgatttt ccaagacccc tatgcatccc tgaatccgag 1224841 aatgacagtt gctgatatta ttgctgaagg ccttgatatt cataagctgg caaaaacgaa 1224901 aaaagagcgg atgcagcgag ttcatgaact attggaaaca gtgggattga acaaggaaca 1224961 cgcgaaccgc tatcctcatg aattttccgg cggccagcgc caaagaatcg ggattgccag 1225021 agcgcttgct gttgatccgg aattcattat cgcggatgag ccgatttccg ctttggatgt 1225081 atccattcaa gcgcaggtcg tgaatttaat gaaagaactg caaaaagaaa aagggctcac 1225141 atacctgttt attgcccacg atttatcgat ggtcaaatac atcagtgacc gcattggcgt 1225201 catgtatttc gggaaactgg ttgagcttgc gccggcagat gagctttatg aaaatccgct 1225261 tcacccatat acaaaatcat tgctttctgc gattccgctt cctgatccgg actatgagag 1225321 aaatcgcgtt cgccagaaat atgatccgtc tgtccatcaa ttaaaggatg gggaaacgat 1225381 ggaattccgt gaagtcaaac cgggacattt tgtgatgtgc acggaagccg aatttaaagc 1225441 tttttcatga ttcatcaatc cttcaagaga tttctcttga aggatttttt tgcgtcttca 1225501 tagaaagtga gaatgataac atttacaatt agaggaaaaa gcggaggcga aatacgattc 1225561 aatttctgca taacaaaaat gtttttgcgc tattgctgtc tcaatctttt caatctttag 1225621 caggagtcct cgtcacaatc gttttaatgg tccggatcta tcaaatgact gactccgttt 1225681 ttttggcggg ccttatttta tcgttcatgt cgtttgcgag tatagcagca agcttttgcg 1225741 tctctccggt gcttcgcatt ctcggtttta aaaaggtgct tgcgggagcg aatctgctga 1225801 gagcggtctt tattatactg atggcataca gcgtcactca tcacggacag gcattctttt 1225861 ggattacgct gctgtttgtg ttttgttttt ccttcgcggg cgcttttttt cagccggcaa 1225921 gatttgcgct gctgccgatt attgttccaa agaagcaata tgtaaaagcg aatggtgtga 1225981 tctccctctc gaatcaattg ttcttaacag caggctgggg ccttggaggc cttctgacgt 1226041 acgccgtccc ttttgaactc gttgtcggcg ctgccatttg cctgtttgtt ctatcgggag 1226101 cttccatcag tgtgctgcat gtaaatgaag aagaggctgc aggaactgct gaaacagcat 1226161 ctgtcagaag tatatggaag gatttaatga tcatccctat tgtaagagac attactgtaa 1226221 tggacatgtt agaagctttg gcgggttccg tatggtcatc tgctattctc ctcgcattta 1226281 ctgcggctgt tttgcatgaa acagaggtgt ggtgggggat gtttaacgct tcctatttta 1226341 taggcgcaat tgtcggcagt gtgattgcta ttcgtttttc ttcttttttt gagcggaata 1226401 tgggctatgc cattatgttc agctcgcttg taatgtcggc gctgaccctt ttgttttcat 1226461 tttctccagt cccattttta tgcgctctgg cttgtgctgc aatggggcct ttttatcagg 1226521 tgcgtgatat ttgccaggaa accatgctgc aggaagttat tcccgagcag aaacgaatcg 1226581 gaatcatggc tgcaaaaaat gcgattttga ctccttggtc aggcgtcacc tactccatta 1226641 tggggctagt ggctgatgct gctggtgcga aaatagcttt tatcgcggct gctgcattat 1226701 atatcatgac atttctgatt gcactggcgc agccccgtct ggttcattac aggcgagaaa 1226761 atcgagttca atgagaaaca cttcaaaatg aacggagcag ctggctccgt tttgctgaaa 1226821 aaaaaatgaa accatggcgg aagttcgcac gtctttatag atgtaaggct gtttaaacaa 1226881 gaagaaatgg ggtatatcta aaagtatgaa gacaacgaac tcataaggag caaatcaatg 1226941 aactggtatg aaaagcttag cgagtacttt ccaattgaag aaatgaaatc aaaagcgcat 1227001 atggaagctc ttctgaaaga gcgaagcgat atttatcata aagatgaagg caaacatcat 1227061 attttaatgt ttgcggaatt cgattctttt atcttcgttg attatctgta tgtgtctaag 1227121 gatgcaagag ggcaggggct tggcggcaaa ttgatcgcga agctgaaaaa gaaaaataag 1227181 cccatattgc tcgaggtgga acctgtggat gaagatgata ctgatacaga aaaacgcctg 1227241 aggttttatc aaagagagca tttcaagcat gctcagtcaa ttgggtaccg gcgccggtca 1227301 ttggctacga atgaagtaaa caagatggag attctgtact ggtcaccaaa aacagaatca 1227361 gaagaagaaa ttcttgaagc catgaaacag acatatgaaa acattcatac ttataaagat 1227421 gagaaatggt acggagaatc gtacgaaaaa acggatgagg tcttggaaat catcgatgaa 1227481 gaaaaacaaa aaaatatttt cgatcagtta agctaattga gaataagaac atatcatgaa 1227541 cattaaaaat ttgctggatt gacacatttt tttcttagga tactgttcac acttactttt 1227601 ttatagtata atacctgtaa agattccttt tttagagtaa tttcaattta agaataaaat 1227661 agatgttcat cctactaatt agaggagtga agatgaatgg ttacactata cacatcacca 1227721 agctgtactt catgcagaaa ggcgagagcg tggctcgagg agcacgagat tccatttgta 1227781 gaaagaaaca ttttctctga acctttatca attgatgaaa taaaacaaat tcttcgaatg 1227841 actgaggacg gaacagatga aatcatctca acccgttcaa aagtattcca aaaactgaat 1227901 gtgaacgttg aatctatgcc gctgcaagat ttgtaccgct tgatcaacga gcatccaggt 1227961 ttgcttcgcc gtccgatcat cattgacgaa aaacgtttgc aggtcggata taacgaagac 1228021 gaaatcagac gtttcctgcc aagaaaagtt cgctctttcc aattaagaga agcacagcgt 1228081 ttggcaaact aatagatcgt atcatcaaaa gaaggctgag tcatcagcct tcttttattt 1228141 ttcaacctgc tggtaataaa tgctcgcaag gatgacaaac gcaaccgtca aaatggggag 1228201 gagcgtttcg actgtgccgt gctgcgccat aaaaagcgac agctttttgt ctctgacaat 1228261 catttctccg ccagtataag caagcagccc gcttcccgcg taaatcagaa gcggtatttt 1228321 ctctagtgca atatggatga gtttgctgcc ccaaataata accggaaccg atacacacaa 1228381 tcctataaca acgagagaaa actcaccgtg tgaagctccc gcaactgcga tgacgttgtc 1228441 cagcgacata aagagatctg caagcacaat cgttcgtatc gctctccaca gggaggtgct 1228501 gcttttaatg tgtttcgtgt cttttttttc aatcagcagc tgatatccta aatacagcag 1228561 gaaaattccg ccggcgcact gcaagaacgg aatgttcaaa agatatactg ctgcacttgt 1228621 taatccgatt ctcatggcaa cggcaataaa tgttccgaga ataatggctt gctgtctttg 1228681 cttgtccggc aaatgtctgc tggccatggc aataacaacc gcgttatctc cgccgaggat 1228741 caggtcaatc ccaacaatga cgagcagaga aatcagatag tcatgctcca tgaagcggca 1228801 cctcgctttc agtccttcgc ttgtactact actatatgag acaggtcata ttttatgata 1228861 tcagccgcct gatctgccgt tttttaggca aaggtgcatt tttatttctt ttgtgactgt 1228921 tttatcataa aatagaaata caaaggaatt cacactggcc ttggttaagg ttaagatgtg 1228981 gacggaatgg gtaaagtgta gtaaagtaca attaatcggg agcttagatg tcccttcaac 1229041 atcttatata gaagggaagg ttggcaaatg gaaattgaaa gaattaacga gcatacagta 1229101 aaattttata tgtcttacgg agatattgaa gatcgcggtt ttgacagaga agaaatttgg 1229161 tataaccgtg agcgcagtga agaacttttc tgggaagtca tggatgaagt tcatgaagaa 1229221 gaggaattcg ctgtggaagg cccactttgg attcaagttc aggcactgga caaaggatta 1229281 gaaatcatcg tcacaaaagc ccagctttcc aaagacggac aaaagctcga actgccgatt 1229341 cctgaggata aaaagcaaga accagcatct gaggatcttg acgccttgct ggatgatttc 1229401 cagaaagaag agcaagccgt caatcaggaa gagaaggagc aaaagcttca atttgtcttg 1229461 cgatttggcg attttgagga tgttatttct ctatctaaat tgaacgttaa cggaagcaaa 1229521 acgactttat attcgtttga gaaccgatat tatttatatg tagatttttg caatatgact 1229581 gatgaagagg ttgaaaatca gctaagcatc ctgctggagt acgcaactga atcctcaatc 1229641 agcatacacc gtcttgaaga gtacggcaag ctgattattt cagagcatgc tctagaaacg 1229701 ataaaaaaac actttgcatc atagcaaacc gatttccttc cggaaatcgg ttttttttat 1229761 gcacgaaaat gccattttag agatgtgaaa aatcaaaaac atatagacaa gcagaaaata 1229821 cagcgaacag gagttgatca tcttttccag aaagtatact tcatctggaa aggagagatg 1229881 acaattgttt agtgctgtga ctgaagacgg ccaaatgttt caccttctag gcgctcagca 1229941 aaaccagaaa ttaaagcgga gacggttctt ctgtccggta tgcgggggag agctagctgt 1230001 gaagctcgga cttcaaaaag cgccgcattt tgcccataaa cagaacaagt cctgcgccat 1230061 agacatcgag ccggaaagcg cctaccactt agaaggaaaa agacagctgt atgtatggct 1230121 gaaaacgcaa cgggcttcac caatattgga gccgtatata aggacaatca accaaagacc 1230181 ggacgtcatg gcaagaatca aggagcatat gcttgctgtt gaatatcaat gcgccactat 1230241 cgctccagat gtctttcaaa agcggacaga gggcttcaaa caagaaggaa tcatcccgca 1230301 gtggattatg ggatacagcc gcttaaaacg gactgcttcg tccttttatc agctttcaac 1230361 ttttcattgg cagtttatca atgcaagtcc atacagagaa ctgatatgtt attgtcctga 1230421 aaggcgttct tttctccggc tcagccacat cattccattc tacacaaacc attcttattc 1230481 ctcagtccaa acgatcccta tccatcgggc aggtgcaggc gatctttttt tcactgaacc 1230541 gaaaccctca attcaatatt caggctggac gaaagcgatt caccgttttc gccataaacc 1230601 ccatcggttt aactcaaagg aaacaaatcg ccttaggctg ctgttttatg agaaacgaca 1230661 gacgcctttt tcttttctgc cgactgaagt gtttgttcct gttagaaaag gggcagtttt 1230721 taagagtccg gtttttgtgt ggcaggggtt tctttatttg tttatgacgg atcttggagg 1230781 taaacgtgcg ccaattcgtt tttcagccgt tttgcagcag tgcaaactgc acattcataa 1230841 taagaacatt gcactcaggt ccgaatgcag cgaagagtgt ctttcagaag cggttaaaca 1230901 gtatattgat tttttgtgca agaagggatt tttaagggag actcagaaag aagtatatgt 1230961 gctgaatcag cctgcaggag gcatacactc catgcaggat ctcatagaaa gagaccgcag 1231021 ctgttttata gaatgagttt gtcttatttg gctcacccta agacaaaggt ggtgggcagg 1231081 ctgtgaaagg cacaaaagga aaggtttttc gtgtttttac tgcttttttg gcattcgttc 1231141 tcttcattac tgcatatgat ttgacaaaag gcagtgaaaa accggaagat attcacaaca 1231201 caagtttatt gagaaacagc tgttttttca attggcttga atcaaagaag acgaggggga 1231261 tcaccatggc tgaggaaaaa aaagcaaacc aactgcctga cagaagtgag gtaaaggcag 1231321 aagacacatg gagacttgag gatatttttc ctagtgatga ggcctggaat aaagaatttc 1231381 aagctgtaaa agaattaatt ccgaatttat ctaagtataa aggaaagctg gcagattcag 1231441 ctgatcattt atacgaggct cttacgtatc aagataaagt gatggagcgg ctaggtaggc 1231501 tgtacacata tgcgcatatg cgctctgacc aggatactgg gaactccttt taccaggggc 1231561 tgaatgacaa ggcgggaaac ctgtatacac aggccgcaag cgcgacagct tatttggttc 1231621 cggagatttt atccatagaa gaagacaaac tgcagcagtt cattcttgaa aaagaagaat 1231681 tgaagctgta ctctcatgcg attgaggaga ttacaaagga acgtccgcat gtgctgagcg 1231741 agaaggaaga ggcgctgctt gctgaagcct ccgaggtact ggggtcatct tcaaatacat 1231801 tcagcgtgtt aaataacgca gatataacgt ttccatccat taaagacgaa gatgggaatg 1231861 aaaaacagat cactcacggc aactttatta atttcttgga aagtgaaaac cgtgaagtcc 1231921 gcaaaaatgc gtttgacgca gtgtataaaa cgtacggaca atataaaaac acaatggcca 1231981 cgacgctaag cggcactgtg aaaaaggaca acttctacgc gagagtgaaa aagtacaagt 1232041 ccgcgcgtga ggctgcgctt tctaacaaca gtattcctga ggaagtatac gataaccttg 1232101 ttaagacgat taataagcat ttgccgctcc tgcaccgcta tattgcgcta agaaagaaag 1232161 tgcttgagct tgatgaagtg catatctatg acctgtatac accgcttgtg aaagatgctg 1232221 ggatgaaggt gacatacgag gaagccaaag attacatgct gaaaggcctc gcacctttag 1232281 gggaagaata tgcctctatc ctaaaagaag gactggaaaa ccgctgggtg gacgtttacg 1232341 aaaataaagg caaacgcaat ggggcttatt catcaggagc ttacggcacg aatccgtata 1232401 ttttgatgaa ctggcataat aacgtcaata atctctttac gctcgtgcac gagtttggac 1232461 attccgtaca cagctactat acgagaaagc accagcctta tccatacggc aattacagca 1232521 tctttgtcgc ggaagttgcc tctacgacaa atgaagcgct ccttggcgaa tatttgctga 1232581 acaatttaga ggatgaaaaa cagcgcttat atattctcaa ccatatgctt gagggcttca 1232641 ggggaacggt cttcagacaa acgatgttcg ctgaatttga acatctgatt catacaaagg 1232701 cgcaagaagg cgagccgctt acacctgagc ttctgacaaa tgtctattac gacctgaata 1232761 aaaagtattt tggagacggc atggtgattg ataaggaaat cggccttgaa tggtcgcgta 1232821 ttccgcactt ctattacaat tactatgtgt atcagtatgc gacaggttac agcgctgccc 1232881 aagcattaag cagccagatt ttgaaggaag gaaagccggc ggttgaccgt tatattgact 1232941 tcctgaaagc gggaagctca caatacccga ttgatgtcct gaaaaaagcg ggtgttgata 1233001 tgacgtctcc agagccaatc gaagccgcgt gcaaaatgtt tgaagaaaaa cttgatgaaa 1233061 tggaagagct gctgatgaaa gtcaagcagt cttaaaaaag taagcctgtg cggaaatgac 1233121 gcacaggctt ttttaaaacc ctttaaaggt tttccggtga ttcaagcggt agagggtaaa 1233181 caaaatagac agaaacagca gaggagaggt aatataaagc ggcagcatat gcatcatgcc 1233241 taagatattc aagcagaaaa aaacagcaat gcacacaatt gagatcaaag tagacatcat 1233301 ggcggtcctc ctcgtccttt ttccttataa ggatatgagt gaatgcactt cgttatgttt 1233361 tgtgacaaaa atatgaacat taagcataga ggttgtcaaa agtcgacatc ttttgttatc 1233421 ataaggatgt gaaattgatc acaaacaaac attacccctt tgtttgaccg tgaaaaattt 1233481 ctcccatccc ctttgttgtc gttaagacat atgaaaccgc gcttatcccg gcgcggtttc 1233541 tttagtgcta aaaatggaac gtacgtttgg ttatggcata aaaaaacagc ctcaagcata 1233601 tgcacgcctg cggctatttt tcacatgatt gatattcatc agaataagtg ctgagagact 1233661 tccaaaacat tccgtgtttg gcttccactt tggcaacctt tttagcaaac gccagttttt 1233721 tcatttcttt ttctacctct tcaaggctca ggtcatatac aagagcaatt tccttcgagg 1233781 caacgaagcg gaaatattca ataaaacatt ctaaaggcgg tgtttccgac ggcttcggct 1233841 cgtcgccaag catctcaaat aaaatttctt catatacatc atatgagtag ctgccaggaa 1233901 ctttaagccc ttcatcctca tgctgcgtat taaaaaacgt cagtgtcgga ttaacagaaa 1233961 catccatctc ggcagcaatt ttcatgtcac attgaagcgc cttgaccgcg ctttgagaat 1234021 gcagatcttt tttgaattct tcaagatcga gacttgtatt ttcagcaatc tccaaaagca 1234081 cgttttcatc cgtaatattt ttctttgaaa caaataggct ctcctgcata tttctgagaa 1234141 attgcatgcc ggcttttcgt ccttgcagtt cggctgcttt aaaagcgaga gcagccatat 1234201 aaggcgatga aagcggctga tcctgttcga accagacatt gccgtcacat gacatgccag 1234261 agcggctcgc gatcttttcc catgcttctg cgagaagatg cttttttcgc tttttattta 1234321 aagcggtaag gcttgcggaa gcgataatgc gtaaggtgaa aaaacgtccg tatctgattt 1234381 tcagcttttt gatgacgggc tctaaggacc agcattcagg acataaaggg tctacaaaca 1234441 tataaatttc aagcggtttt tttggatgac cgtggcaatg ggcgaagtat agctcatgct 1234501 gatagtttgt caagatgatc gatcctccgc ttccgtttga ttcaccatat gccttgctgt 1234561 caactccagc cggccaaaca aaaactcacg aatttcgccc tccagcccta catggtccat 1234621 tgcgtccttc atacagctga gccacgcatc agctctctcg tttgtaattg gaaagggaag 1234681 atgccttgct ctgagcatag gatggccgtg ttcctcagta taaagaggag gcccgcctaa 1234741 atactgagtt aagaattgct tctgtttcct ggcggtttct gtcaaatcgc ttggaaaaat 1234801 cggcttcagc aaaggatgag acgcgacacg ctcataaaaa gtatcaacaa gttgcgatag 1234861 aagttcctct ccaatcgctt cataaggtgc gttaaacgat tgtcccatgt tgactactcc 1234921 tttaaatatg gctaatagga atcataaatc ctattgcaaa aagtaatttt ctgtatttca 1234981 ttgtttcatc tagatttatt ttagcaacaa ggcatcattt ctacaaacaa actgcctttt 1235041 atgcgtttga tgactcattt cggctgacag ccggggtttg tatttcatat catatcacat 1235101 aaaaatcagg aatgcgtaag atttcacttc gcaaaaaaac cagagggaaa gagcacctct 1235161 ggttacgcgt aataaactga agttattttt tttacatagt tttgcgtttc ttggaaagga 1235221 ggaatgcctc cgtatcggtc aacattcccc ggtccggcgt tgtaagccgc taatgccata 1235281 gacacattgc cgtcgtattt atccagcatt tgttttaaat atttcgttcc gccctccaca 1235341 ttttgctgcg gatcaagcgg attggaaacg ccaagtgagc ttgctgttga cggcatcagc 1235401 tgcatgaggc ccatcgcacc tgctccgctg accgcttttg cattaaagcc tgattcctgt 1235461 ttgatgacgg cgcggatcag tttttcatca acgccatatt tatcagcggc ttttttaatc 1235521 gcactgtcaa tagagaagtc tcccgaacgg atctgatttg cttcatgttt gtttgaagct 1235581 gaatctgcaa cagctgtttc agtgctttct gccgcttttg tgactgaacc tgaattgctg 1235641 ctcgtatatg agttaagccc atacgctgaa agcagtgacg gcgctgttgt attcgcgctg 1235701 ttcagcatgc tgagcgggct tggcgatgaa gaaggtgctg attgctgaga tgtcagaccg 1235761 tttgtatatt ggctgagcaa agaactgaaa cttgaaagcg ggctttccgt attctgagtg 1235821 tccgagctgc tgcgtgcatt agatatggac tgtaatgcct gaagctgaag taatgctgcc 1235881 caattcgtta cattcacgat gtcattccac cttatataga ctttcgtttt tcttcataaa 1235941 aacgcagaat tttatttttg gtttcgcgct gaggaatgct gaattgctga agcagctttt 1236001 cgaaggcttg tctgccctca tgccaatccg ccgcctcaaa ttcaatttca tagtcctctt 1236061 tatttaaata tcggctgtgg tctaaaacta ttaagccttt ttctgtttct ttttccgcac 1236121 ggtttgttgc taaagatcca aagtattgta tggcatccgt atcgatctga agcttgtgca 1236181 gctggtcctt cacagggccc tcgggaactg aaaatccagc gagatctgat acctctgaaa 1236241 gctgctggtg cgtttccaga agccccacat cagccggctc ctttaatgta aggacatact 1236301 ttccgttttt tctgcggata cgaagcgcag catgtttttg tttcagcgcg aagctgtctg 1236361 tatcaaaata atgattcttt tgatctgtaa aatctttttc tgtcagctgg agtgccgatg 1236421 ctatgttttt gaattcttgt ttggtcagca tgtttttaaa ttcgatttca atctcttggc 1236481 tcatgatgct cttcctttcc gccctgtaaa tcttattttt actattatct ctttagatgt 1236541 taggtttatc aatatcgagc tcgatatgat aaaatgaatc tgtactttgt ttaaaaaagg 1236601 agagcattat gcaaaacaga atcgaaattt tgaatgcaac attatcggat gatcagcttc 1236661 gccttgcctg tcagacagaa ggaaacgaag cggaacgcaa gccgtcaggt caaatgcttg 1236721 ttgattctga ccactttgct tttgtataca tacttgaatt agctgattct tttgaatatg 1236781 tcattataaa ggaacatgta tggccggaac tgaagcaggc ccatgcacaa aaaataccgg 1236841 ttgttttaga ggcaggagac caaacaattg aactggcagg cctgcatgag gagctggaat 1236901 atcttttaga aaatataaaa gataatgcaa actatggaga agaaatggaa gaaaaagtga 1236961 aacgcgtgtt tttatagaaa ctggttcgga attgggggat gtatgatgga tgacaaacaa 1237021 tgggagcgtt ttttagtgcc gtaccgccag gctgtcgaag agttgaaagt gaagctcaag 1237081 gggatccgca cactatatga atacgaggac gaccattcac cgatcgaatt tgtgaccgga 1237141 cgcgtcaagc ctgtggcgag catacttgaa aaagcgagac ggaaaagcat accgctgcat 1237201 gaaattgaaa ccatgcagga cattgctggc cttagaatca tgtgccaatt tgtcgatgac 1237261 atccaaatcg taaaagagat gctttttgcc agaaaagatt tcaccgttgt ggatcagagg 1237321 gattatattg cggaacataa agagagcgga taccgatcat accatcttgt tgtgctgtac 1237381 cctttgcaga cggtatccgg agaaaagcat gttctcgtag aaatacagat ccgtacactg 1237441 gcgatgaatt tttgggcgac cattgaacat tcattgaatt ataaatacag cggaaacatt 1237501 cctgaaaaag taaaactaag gcttcagcgc gcttctgaag cggcttcccg gcttgatgaa 1237561 gagatgtcgg agatcagggg tgaagtacag gaagctcaag ctgccttttc aagaaagaaa 1237621 aaaggaagcg agcaacaata ggtaaagggg aagaagagca tgaaatttgc cgtatcatca 1237681 aaaggagatc aagtttctga tacgctgaaa agcaaaatac aggcgtattt attggatttt 1237741 gatatggaac tggatgaaaa tgaaccggaa atcgttattt cagtcggagg cgacggaacg 1237801 cttttgtatg cttttcacag atacagcgac cgtttggaca aaacagcatt tgtcggcgtt 1237861 cacacaggtc atctgggttt ttatgccgac tgggttcctc atgaaattga aaaacttgtt 1237921 cttgccatcg cgaaaacgcc gtatcataca gtcgaatatc cgcttctcga agtcattgtg 1237981 acctatcacg aaaacgagcg ggaagaaaga tacttagctt tgaatgaatg tacgattaaa 1238041 agcatcgaag gaagccttgt tgctgatgtg gaaatcaaag ggcagctctt tgaaaccttc 1238101 cggggcgacg gcctctgcct gtcaactcca tcaggcagca cagcctacaa taaggcgctg 1238161 ggcggagcga ttatccatcc gtctatcagg gcgatccagc ttgcggaaat ggcttcaatt 1238221 aataaccgcg tgttccgtac ggtcgggtca cctctgcttc tcccatccca tcatgattgc 1238281 atgattaagc cgagaaacga agttgacttt caagtgacga ttgaccattt aacccttctc 1238341 cataaggatg taaagtcgat ccgctgccaa gttgcatccg aaaaagtgcg gtttgcgaga 1238401 ttccgtccgt ttccattttg gaaaagagtc caggattcgt ttattggaaa aggtgaatag 1238461 aaagaggaca tatcgtggag cattttttta tcagaaagaa cattacttcc gctgaggacg 1238521 ggatgactgt aaaagaatat gccggtgaac tgggaatttc gaaacgtctg ctgaccgata 1238581 ttaagtttgg cgggggagac ctgcagatta acggtgagca tgtgacggtc aaatacgttt 1238641 tgaaagaggg agatcttctt atcgtgaagt ttcctgagga gcaggtgagc gagacgctgt 1238701 tggcagagcc tgttccgctc gatatccttt atgaggatga acatgtgctt gtgataaaca 1238761 agcagccgta tgtgtcatca atcccttcga gagagcaccc ctccggcagc attgccaatg 1238821 gaattattga tcattatcaa acaaccggag tgagggcgac agttcatctt gtcacccggt 1238881 tagaccggga tacatcaggt atcatgcttg ttgccaagca tcgatttgcc cactccattt 1238941 tatcgtctgc gcaaaaaaac ggccttgtga aacgccggta tgcggcagtg gttcacgggc 1239001 ggatggcaca gatggaggga acagtcgatg ctccgattgg cagacatcct gacagtatta 1239061 ttgaacggac ggtaacgcca gacggccaga aggctgttac tcatttttac gtcacatgtg 1239121 caaatgatga catgacctcg gtggcattgc agcttgagac tggacgaacc catcaaattc 1239181 gtgttcatat gagctatctc gggcacccgt tgtgcggcga tacactgtac ggcggaacga 1239241 gacaggaaat tggccggcag gctctgcaca gcgagcatct ttcgtttatc catccgctga 1239301 cacaggagaa catgaggttt catgctccac tgcctcagga catgagcaaa ctgataaaag 1239361 gagagaatca ttgattctct ccttttttat atggggcgaa atcttgattc gtcgtaaggc 1239421 agggagcttg gaacagagac ggtttctatt tctggaaagc gaaagcctgt cagttgattt 1239481 ccgaacacgc agcctgtatc aatgttgatg gtgcgattga ccttccgagg ctctttcaca 1239541 ggtgtatgac cgtataccac ccaagccttt ccgttatagg ctgccgccca atcacgcctg 1239601 atgggtctgc cgtccggata tgtttcaccc gtcacgtcac cgtaaagcac aaagtccttc 1239661 actctgcggg tatatttgcc gatatcgtca gctcttatgc cagcatgggc gacaactaat 1239721 tctccattat gtaagatgtc gtaaagcggc gctgtttcgt acagcttcat aaactgttcg 1239781 ctgactgatt ttttctcatc tttggaaagt tcctcaagct ctgccgctgt tgtttcgaga 1239841 ccatgcatca cttttaccgg atttcctttt aagtaacgat ataatttatt gcaatggttt 1239901 cccgggacat aacgcacagc gcctttttcg taagcgccgg ctacaaatcg gatgacctct 1239961 atcgatttgg gccctctgtc agttaaatct ccggcaaaaa caagcaccct gccttcttca 1240021 tggacaggta ctccattttt gattgtatag ccaagctttt ggattaatgc agtcatttcg 1240081 tcatagcagc catgaatatc gctgatgata tcgtaagcca tgcggtctcc tccttaccga 1240141 ttgttttatt tattatgaag caaagtgttg tgagtcatca caagctttta tgtgcaaatt 1240201 atagaagaag aatcattttc taaacaggat taagacctta tcactttatt tttcatcatc 1240261 acccttgtta aaatcgcgtt atgtttttta aaaatgaggt tttgttctct gagtgagaac 1240321 tagcataacc ctgacttaaa aaggaggttc tgattatggc gcatacatct gtcgcatctt 1240381 tagttgttgt acttatcgtt gcatttttga cacccatcct tttgcatcgg tttaaactca 1240441 gcatcccggt tgttgttgct gaaatcatta tggggctgat aattgggaaa agcggcctta 1240501 atttagttgt ggagggtgac acctggctcc agacactctc tatgctcgga tttatctttt 1240561 taatgttttt aagcgggctt gaaattgatt tttcgtcgtt tgagaaagga aagaaaaagc 1240621 agttcctgcc gaatggcaag gaagcgccga atacgtttgc tgcggcatct gttattttcg 1240681 tcggtatttt tattttatca ttgctcttgt cctatgggtt cgtcttggcc ggatttatcc 1240741 aaaatgcatt tttgatgacc ctgattattt caacgatttc attaggcgtt gtcgttccaa 1240801 cattaaaaga agaacggatc atgaattcga atatcgggca gattattttg cttgttgctg 1240861 ttattgctga tttggccacg atgattcttc ttgctgtttt ttcttcttta tacggagagg 1240921 acagcggaaa catgtggctc ctgatgattc tgtttgcggc cggagtggtg ctttactttt 1240981 tcggccgggt cttcaaacat cgctcttttg ttcaatccat gtcaaaaggg acgatccaga 1241041 tcgggacgcg tgccattttt acgttaatca ttgtactcgt tgccctgtct gaatcacttg 1241101 gggcggaaaa tattctcggc gctttcttag cgggggttct tgtttccctg ctttcgccaa 1241161 acaaagaact tgttcagcag ctggactcat tcggttatgg gttcttaata ccgattttct 1241221 tcgtgatggt cggtgtgaag cttgatattt ggactctttt ccaggataaa acaattttaa 1241281 tcatgattcc gctcctgctg cttgcgctgt tagtcagcaa aatcattcct gtcatgtact 1241341 taaagaagtg gtatgataac cgaaccattt tcgcgtctgg tttcctgctg acatcaacgc 1241401 tttcgctcgt gattgctgct gcaacaatcg gccagcagct tcacgtgatc agtacaaata 1241461 tgtcaggagc gctaatttta gtagccgtca ttgcaagtat ttttacgccg atctgtttta 1241521 aaaaattata caaacgggaa gagcagccgg aggagaaaaa gacgattacg ttcattggcg 1241581 ccaatcaaat gactttgcct gtcacactcg aattgccaga ggaagagtat gacgtgcgtg 1241641 ttgtacacgt ctaccaagag aatgcggagg aaaagctgtc agaatcagtg tttgctgttg 1241701 aaacaatttc tgactatgaa cacgagacgc ttgaatcact cggcattttt gaaacggata 1241761 tcctcgttgt ggcgacagga aatgaagata tgaatgcaga cattgcatta cttgcaaaag 1241821 ataaaggcac agaaagagtc attgcaagcg taggatcacc ggagcatgaa gcagctctga 1241881 aggagcaggg aatcagcatc ttttctattc tgctgtcgac aaaaacgctg cttcgcgcac 1241941 tgattgaagc gcctggcgtc atgaagctgc tcacgaacca agagtcttcg ctgtatcaaa 1242001 ttaatatgga gaacagtaaa tatgatggtg tcattttacg ggaattccct ttaacaggtg 1242061 acgtcatctt tgtcaggatc ttcagaggtg tggacagcat cgttcctcat ggggatacga 1242121 ggctgaaact tggagaccgt ttaattgtca ccggatctcg ggggtacgta acggatctta 1242181 agaaaacatt ggaaggataa atcttgacca aataaggatt cgtgttaata tagaggtgca 1242241 gaacaattca atatgtattc gtttaaccac taggggtgtc cttcataagg gctgagataa 1242301 aagtgtgact tttagaccct cataacttga acaggttcag acctgcgtag ggaagtggag 1242361 cggtatttgt gttattttac tatgccaatt ccaaaccact tttccttgcg ggaaagtggt 1242421 ttttttattt tcagaggggg aatgatttgt gaagttttca gaagaatgcc gcagtgcagc 1242481 cgcagaatgg tgggagggga gctttgtcca tccgttcgtt caaggaatcg gtgacggaac 1242541 gcttccgatt gaccgtttta aatactacgt acttcaggat tcctattatt taacgcattt 1242601 tgcaaaggtg cagtcatttg gtgccgctta tgcgaaggat ctttatacaa cggggcggat 1242661 ggcaagccat gcccaaggta catatgaggc ggaaatggcg cttcatcgcg agtttgccga 1242721 gctgttggaa atcagcgagg aagagcgtaa ggcgtttaag ccgtctccta cggcgtactc 1242781 ttatacatcc catatgtacc gttcggtttt gagcgggaat ttcgcagaaa tcttagcggc 1242841 cctgctgcca tgctattggc tctattacga ggttggtgag aaattgctgc attgtgatcc 1242901 ggggcatcca atttatcaga agtggattgg cacatatggc ggtgattggt ttagacaaca 1242961 ggtcgaggag caaatcaacc gctttgatga gctggcggaa aacagcacgg aggaagtgcg 1243021 tgccaagatg aaagagaatt ttgtcatctc cagctactat gaatatcaat tttggggaat 1243081 ggcctatcga aaagaaggct ggtctgacag cgccataaaa gaggtggagg aatgtggagc 1243141 ttcacgccat aacggatgac agcaagccgg tagaagagct agcgagaatc atcattacga 1243201 ttcagaatga agttgatttt attcacattc gggaacgctc aaaatcggcg gcggatattt 1243261 tgaaactgct cgatcttatt tttgaaggcg gtatagataa acgaaaattg gtgatgaacg 1243321 ggcgcgtgga tattgcactt ttctctacta ttcaccgcgt gcagctgcca agcggcagct 1243381 tttcaccgaa gcagatcaga gccagatttc cacaccttca tatcgggagg tcggtgcatt 1243441 cactggagga agcggttcaa gcagaaaagg aagacgcgga ctacgtgctg ttcggccatg 1243501 tgtttgaaac ggattgcaaa aagggtcttg aaggcagagg agtatctttg ctgtcagata 1243561 tcaaacagcg gatttccatc ccggttatag ccatcggggg gatgacgccg gacaggttaa 1243621 gagacgtaaa acaagcaggg gcagacggca ttgctgttat gtcaggaatt ttctcttccg 1243681 ctgaaccttt ggaagcagcc agacgatatt cccgcaagct aaaggagatg cgctatgaaa 1243741 aggcattatg aagcagtggt gattggaggc ggaattatcg gttccgcaat tgcttattat 1243801 ttggcaaagg aaaacaaaaa caccgcattg tttgaaagcg gaacaatggg cggcagaacg 1243861 acaagtgccg ctgccggaat gctgggcgcc catgccgaat gcgaggaacg tgacgcgttt 1243921 tttgatttcg ctatgcacag tcagcgtctg tacaaaggtc ttggagaaga gctttatgca 1243981 ttatccggtg tggatatcag gcagcataac ggcggtatgt ttaagcttgc attttctgaa 1244041 gaagatgtgc tgcagctgag acagatggac gatttggact ctgtcagctg gtattcaaaa 1244101 gaagaggtgt tagaaaaaga gccgtatgcg tctggtgaca tctttggtgc atcttttatt 1244161 caggatgatg tgcatgtgga gccttatttt gtttgcaagg catatgtgaa agcagcaaaa 1244221 atgcttgggg cggagatttt tgagcatacg cccgtcctgc atgtcgaacg tgacggtgaa 1244281 gccctgttca tcaagacccc tagcggagac gtatgggcta atcatgttgt cgttgccagc 1244341 ggggtgtgga gcggaatgtt ttttaaacag cttggactga acaatgcttt tctccctgta 1244401 aaaggggagt gcctgtccgt ttggaatgat gatatcccgc tgacaaaaac gctttaccat 1244461 gatcactgct atatcgtacc gagaaaaagc ggaagactgg ttgtcggcgc gacaatgaag 1244521 ccgggggact ggagtgaaac accggatctt ggcggattgg aatctgttat gaaaaaagca 1244581 aaaacgatgc tgccggctat acagaatatg aaggtggatc gtttttgggc gggactccgt 1244641 ccgggaacaa aggatggaaa accgtacatc ggcagacatc ctgaggacag ccgtatttta 1244701 tttgcggctg gccatttcag aaacgggatc ctgcttgctc ccgcaacggg cgctttgatc 1244761 agtgatctca tcatgaataa agaggtcaac caagactggc tgcacgcatt ccgaattgat 1244821 cgcaaggagg cggttcagat atgatgctac agctgaacgg taaagacgtg aagtggaaaa 1244881 aagacacagg tacaattcaa gacctgctgg cgtcgtatca gcttgaaaat aaaatcgtta 1244941 tcgtggaaag aaataaagaa ataatcggga aagaacgcta tcacgaggtt gagctttgtg 1245001 atcgtgatgt cattgaaatt gtccattttg taggaggcgg atgagcatgt taacaattgg 1245061 cggaaaatca tttcaatcaa gattgctgct gggcacgggg aaatacccat cgtttgacat 1245121 tcaaaaggaa gcagtagctg tttctgagtc tgatatttta acatttgctg taaggagaat 1245181 gaacattttt gaagcatctc agccgaattt tctggaacag cttgatttat ccaaatatac 1245241 gcttttgccg aatacagcgg gcgccagtac tgctgaagaa gcggttcgga ttgcaaggct 1245301 ggcgaaagct tcaggccttt gtgacatgat taaagttgaa gtcatcggat gcagccgttc 1245361 cttgctgcct gaccctgttg agacattaaa agcgtctgaa cagcttcttg aagaaggctt 1245421 tattgtgctc ccgtacacgt cggatgacgt tgtgctggcg agaaagctgg aagagctcgg 1245481 cgttcatgcc atcatgccgg gtgcatctcc gattggatca ggacaaggaa tcttaaatcc 1245541 tttgaatctg tcgtttatta ttgaacaggc gaaagtaccg gtcatcgtgg atgcgggaat 1245601 cggctcgcct aaagatgcgg catacgcaat ggagcttgga gcggatggcg tactgctcaa 1245661 tacggctgta tctggcgctg acgatcccgt gaaaatggct cgtgccatga agctcgcagt 1245721 ggaagcaggg cgcctttctt atgaggcggg ccgaatcccg cttaagcaat acggaacggc 1245781 aagcagtccg ggagaaggtc ttcctgtatg acaggcaggt attcaaggca ggagctgttt 1245841 gctccgatcg gcccatccgg ccagaaaaaa ttgaaagaag cgcgcgccgt gattatcggc 1245901 gccggcgcgc tcggaacagc cagtgcagaa atgctggtga gagcgggagt cggctctgtg 1245961 aaaattgccg acagagatta tgttgaatgg agcaacctcc agcgccagca gctttataca 1246021 gaagatgatg tcaaaaaaga aatgccgaaa gcagccgctg cggagcgccg tctccgttcg 1246081 attaacagcg atgttgatgt gaccggcctt gtcatggatg tgacagcaga aaatatcttc 1246141 gagctgatta gggatgcatc gattattgtg gatgcggctg ataattttga aacccgcctg 1246201 atcgtaaatg atgctgcggt aaaggaaggg attccttttc tttacggtgc ctgtgtaggg 1246261 agctacggtc ttacctttac cgtggtgccg ggttctactc cttgcctgca ttgcttgctc 1246321 gatgcacttc cgattggcgg agcaacatgt gacacagctg gcatcatcag tccggctgtt 1246381 ttgcaggtag cagtctttca ggtaacagat gcactgaaac tgctgacggg agaggagtgc 1246441 gagccggtgc tgcgctcctt tgatttgtgg aaaaacgagc ggtcagaagt gagagcggcc 1246501 agtctcaaac atgacgcatg cccaagctgc ggcacaaagg attttccgtt tttgtcttat 1246561 gaaaatcaaa caaaagcggc tgtattgtgc ggcaggaaca cggtgcagat cagatcatct 1246621 attacgaaag aagcggatct tgaagcgctt gccggtcagc tgaggcaggc cgggcttgaa 1246681 gtagctgcga acccgtattt aatttcctgc cgctcggatg atatgaaaat ggtgctgttc 1246741 cgggacggca gagctttgat ccatggaaca aatgatattg cccgggcaaa atccatttat 1246801 cataaatgga ttgggtaata aaaggagtgt agtgtaatga gtatatataa agcattgaca 1246861 atcgccggat cagattcagg cggcggcgca gggatacagg ctgatattaa aacctttcaa 1246921 gagcttgatg tattcggaat gtctgcgatt acggcggtaa ccgctcaaaa tacgcttggc 1246981 gttcacgggg tgcatccgct gactgtagag acgttgagac agcaaattga cgctgttgct 1247041 gaggatttga gaccggatgc agttaagacg ggaatgctct ggaatgccga catgattgaa 1247101 gaagtggcaa gaaaaattga cgagtacgga ttcaatcgtg taattgttga tccggttatg 1247161 atcgcaaagg gcggggcatc cttgctgcgt gatgagtcag ttgccacctt aaaggagttg 1247221 ctcattccaa gaagctacgc gattacgccg aatgtcccgg aagcagaaac gctgacagga 1247281 atgacaatca gctcgctgga tgaccggaaa aaagcagcgg agcagctcgt caagatgggt 1247341 gcgcagcatg tcattatcaa aggcgggcac cagcctgagg acaatcacat tactgacctt 1247401 ctttttgatg gcagcatgtt tatgcaaatc acccatcctt atatcaatac gaagcatacg 1247461 catggcacag gctgcacctt tgctgcggct ttaacggccc aaacggctaa aggagacagc 1247521 atccatcagg catttgaggt tgcggccaac tttgtccgtg aagcggtgga aaatacgctc 1247581 ggcatcggat cgggacacgg gccgacaaac catttcgctt ttaaacgaaa cagcttaaat 1247641 acaagccgat gagatcacca gctgatggtg atctcttttg cgtttgctac ggtatgcgct 1247701 tttcatctgg acaaggttat gatatgatag gaattaagat caggtactaa tactatgtct 1247761 ttattaaata taggaggctt tatacatatg aatttttcac ttgaaggccg taacattgtt 1247821 gtgatggggg tagccaacaa acgcagcatc gcctggggca ttgcgcgttc tttacatgaa 1247881 gcgggtgcac gtttgatttt cacatacgct ggtgaacgcc tggagaaatc cgttcacgag 1247941 cttgccggaa cattagaccg caacgattcc atcatcctcc cttgcgatgt tacaaacgac 1248001 gcagaaatcg aaacttgctt cgcaagcatt aaggagcagg tcggtgtaat ccacggtatc 1248061 gcgcattgta tcgcgtttgc caacaaagaa gagcttgtcg gcgagtactt aaacacaaat 1248121 cgtgacggct tccttttggc tcataacatc agctcatatt ctctgactgc tgttgtcaaa 1248181 gcggcacgtc cgatgatgac tgaaggcgga agcattgtca ctttgacgta ccttggcgga 1248241 gagcttgtga tgccaaacta caacgtcatg ggtgtagcaa aagcttctct tgatgcaagt 1248301 gtgaaatatt tagctgctga cttaggaaaa gaaaatatcc gcgtcaacag catttctgcc 1248361 ggcccgatca gaacattatc tgctaaaggc atcagcgatt tcaactctat cttaaaagac 1248421 atcgaagagc gtgcaccgct tcgccgcacg acaacacctg aagaagtggg cgatacagct 1248481 gcgttcttgt tcagcgatat gtcccgcggg attacaggtg aaaatcttca cgttgattct 1248541 ggtttccata tcactgcccg ctaagcagga tctatatcaa gcaatcccga atagggattg 1248601 cttttttatt tcttctgatt ttcagctttc tgtcatatag atagaatatg acacaatcgg 1248661 agggatgaag atgtctaata agaaaagaaa cgcggataaa aaaccgctca tgtatattgt 1248721 tcagccggat tatgcagaaa ctacaaggtc atccatgcag gagattgtca tcaaaagaaa 1248781 ggccgacaaa cccgctccgc caaaagctga ggaaaagccg gcttaccatg agaagcagca 1248841 ggaggaagcc gtggcacagg atgtcctgca agaagaccaa aagcctgcag ccgaaccagt 1248901 gagtcagcaa acacaagagg cgagagagcc agagaacata aaaagccaag aggaacagaa 1248961 ggcagagccg caggccgtag aagaaaccgt tgaacacgag cccccgaaag cagaaaaaaa 1249021 ggaagagcct gcacttgagg cccggaagcc tgagaaagaa ccggaagctg tccatagtgc 1249081 tgataaagcg gaggaaaaag caccgccggc acgaaaagtg aaaaaaccga tgagcaagat 1249141 gacgatccac gaaaaaattg attttttaac aaagctgcct cataacatgc cgagagcgct 1249201 ttgtttgatt gaagccaatg gaagaacgta caggggcgtg attgtcggaa gaagaaatga 1249261 ttccgtcctg cttcgaacaa ccggaaacgg agccccaacc gaactggcaa tcgatgatat 1249321 tacctctttg cacccgctcg gtttttaacg aaaaagaaaa aagctgcccg gctgatgttg 1249381 ccggacagct ttttttacat agagaaaagc ctgcaggcct gcaagctttt ccagcttatg 1249441 attaatgatg atgtgtacga ttgattaatc gaggatttaa gcagttgatt gcgcagaagc 1249501 agtctaagtc aacttcaata cagtagttcg ttttttcgag tcggaacact tcacacaccg 1249561 tatctttatc ggtgaagtcc aaaatgtgtt tgtgttcgtc aaatgcgatt aataatgaca 1249621 gtgttgcaca gcttccatgc actctttcga ccctgaaaaa tactgtatta aagcaagggc 1249681 cgttatcgag ttcgccgaca tttccgaagg cgactaatgg cgttgatttt gatgtaaata 1249741 ttgcaaaagg cactgtgtcg cctaacgaat ggcttacaga taaaagctta gagtggcagc 1249801 cggtcgggca gtcttcttca acagcgtttt gcagatcttc aatattttct acagcttcac 1249861 gcacgcagct tgatgttttc tggctcatat tatccctcct gccttataaa tttgagactg 1249921 gcgaaatgat ggagagtcag ctgcctcacg ctggaagcag ctgaatgatt tgcacctgta 1249981 atagagtttg gaaggggatt cctctttaca agtgtttatc cattgtgatg atgcttttta 1250041 tctttgtgag gcgatgttct gtcaactagc tctggtgaca ggcactgaat cgcgcagaag 1250101 catccgagat ccacttcaat gcagaaatct gttttttcta gcccgaagaa atccgggtcg 1250161 caagggtggc aaacacttaa ggtatcgcct ttgacatcga ccgggcgtaa aatagacagt 1250221 gttgcacagc aatcgcataa tttttcgacg cggaagaaaa tggattcaaa gcattgcata 1250281 tcatccacaa atccccctac gtttccgaat gtggagaaca atccgccttt tttatcaaaa 1250341 acgagaaacg gaattgtgtc ttttccagca atcgtagggt ttaaaaggtt ggtatagcag 1250401 ccagtcggac actgttcttc aactgcctcc tgctctgcta aaatcttttc cactgcatcg 1250461 catacacagt tctcatgccg gccatgggtt tttccgcagc tcattgattt cagctccttc 1250521 tttatagggt atttgacttt agtccttaac aacatatgta cccgtgcccc acttggtgtg 1250581 ggtgaacgtc tatatattca tcatatgctt ggaaaataag aaaaagcaga gcgtttttag 1250641 ctctgctttt aggtcctaga ggacaagagt gataactagg atggctacga gtgtatttgt 1250701 tgctgtagaa ataagggttg cgatatcggc atctactgtt gtgacgttta cgccgcggga 1250761 acattcgatg agaagttttt ggcggtttac ttgtttgtta gctgtaagct gtaacaaatc 1250821 ttgtgcgact aattcggcaa ttacgccgtc tgcaattgat gtcagagttg ccgttacgac 1250881 agcggcatta agtgctgtta caactgatgt tacggcttga acgtctgtag atgtaacatt 1250941 gatgtcacaa gaatctctaa taataatcgt ttcatctgaa acttgtttgt tgagatttgc 1251001 ttgagctaga tcttggtcga tgaaggcgtt gtcgttgcca aaaaaaccat tgccattaca 1251061 gcaaacgtcg caatgacatt ttctttcgtg tttttcttta tctttctctt tgtcatctaa 1251121 cggatggtca cagtcaggat caagtgcaac ccaagaatat ggtctgcttt ccatatctat 1251181 tcctcctttt cttttactgt tattaaatga gcgagcctct tattttgact gagtcatata 1251241 tcctgatgaa gaaccctatt ttttatgatt ggctaattgt tatcgttttt ccgtctttgt 1251301 ctgatctgtt caatgagctg ctctctgcgg cttaacggtt ttgtgttctt ttgctcttgt 1251361 gcggctgctt cttctttttt cttcttttgg ttttctatta gcgcttgtga tttagcttgt 1251421 aagtctttta caagatttaa gagcatttct ttttcttcgt ctgatacttt tttcattttg 1251481 tcttttgtga ccccatgttt agaaaatata ttttggacca gcattttcgt cattggatca 1251541 acttctggaa gctttgcaag ctcttctttg aatttatcgt tatctgacat ttgttttcac 1251601 ctcgtctttt aagtttgtga aaagaaaggg ttaaaggacg tcaagttcac taagaatgct 1251661 gtttaacacc tgaagcaaga tttgtacaaa ggttattatc tcgtcggcag acaaagtaat 1251721 tttgatgttg cggctgttga taattttaat gatggttctt tttttgattt gggagctatc 1251781 gagaataaga atttcacttg ccactgcgtc agccaaatcc tcgtcggcga tgacgagctg 1251841 agtcgccacg ataatcatgg ttgtcacaaa ggcttgtata gaaagggcag ctgttatatg 1251901 tgacgtgtca attgtgatat tttcgcaatc aatcacttcg atctgctgtt cgaattcgct 1251961 tgataattgc tcaaatattg cagggtgcag ggattcgact ttttcttcaa atgacataac 1252021 cttcactcct ttcttatcca tactctatat aatgcaaatg gggtgcagag cggaataata 1252081 aaaataacca attttctgcc ggacaagata caattcatga agaatagggt tttggcatat 1252141 atgtgaaggg atcatgattg gcaaaggagt gaacgagtgg ttataaatgg gctgacaatt 1252201 gttcttctat cgcttgcggt ctttcggctc gcccgcctgc tggtgtttga cacgattatg 1252261 gcgccgcttc gcagtctgtt tcatgaagag aaggaagaaa aggatgcgga cgggaacatt 1252321 gaaacctata tcgtgattaa gggaaccggt gtcagggcgt ttattggtga attgctgagc 1252381 tgctattggt gcacaggcgt gtggtgtgcc ggctttttga ttttatgcca ggcggtgatc 1252441 ccgcaagcgg cgcagtggct gattttactt ttggcgatcg ccggccttgc cggcattata 1252501 gaaacgctcg tatcaaaatg gctgcaagaa taaggcgtta ccaccagcaa ctttctgtca 1252561 gaatacgcat aaagtagcat atatgacata aggaaaggaa ggggacaaaa atgaatcagc 1252621 atcataaacc ttcccaaaaa tctccatata cagattcatc gtatcaatca aaaaagataa 1252681 aaaagaaagg ctgcgggtgc ggaaataaaa agaaaaagcc tcaatagcct ggcaaagaaa 1252741 ccggagaact ccggtttttt gtttttttaa cgaggcggtc tcgctcagca tatatcataa 1252801 gcggggggat aaaagtgaat gagtttgaaa aatggataga aggaagatat gaaccacatg 1252861 aacaaaagca aaaagagcat gaagacacga tgggcagtat cagaaaagac ttggatgcat 1252921 ttgataaagc cggtctggaa tttgaagatg agattgaaga gctggctgaa aaaacggagg 1252981 ccttacttaa aaaacatcaa gctcaatatg atcaatcgta aatccgcaaa cgccctatgc 1253041 gaatatccaa gccgatccca gcagctcaca tagtgtatag agagtaaagg aggtgcttat 1253101 ctatgggctt tggatacgga ttcggcggcg gctacggcgg cggctgttat ggcggttatg 1253161 ctggcggtta cggcggcggc tatggttcaa catttgtttt gttggtcgta ttattcattc 1253221 tcctcatcat cgtaggtgca tctttctttt aagatgtatt gaggaagtac gggttataac 1253281 ccgtacttcc ttgccttgtg tttattttta aaaatgttgg aaaagcacat tgtattatgt 1253341 gcattcatac aataccgtat tactccgcca aaaggaggcg cattatggat aatcaatttt 1253401 ttaagaacat cgaaaagaaa acaggtgtga agatgcagga tgtaatgaat cttgccggat 1253461 cactccaaaa cgctaatttt aaagatgaaa atacagtgcg cagtgtgatt aaccgcgtag 1253521 cgcagatggc aaacagacgc gtgccaaaag aattagaaga taaaattgtg gaatctatta 1253581 caagcggaaa agaaaagctt gattttggca cgatttctaa aatgatggat aataaataag 1253641 tggatggcct ggctgactca ctgcagcggg ccttttttta cagtaaaaac ccggcagtaa 1253701 tctgccgggc tgttaatgat gcaagggctg tcttgctttc tgtagcaggg gatacaaaaa 1253761 tcttgagcgg ttggctgttt tgccgcgcct gttagcaggg caagacaaat ataaatgctg 1253821 tttcgcccgg gtcatggcta catataaaag gcgtctttcc tcctcaagag cggcctcgtc 1253881 tccttttctt gccgtttcta atgagaaatc gtgcggaatc gagccatcta cagtgcctaa 1253941 cacgtagact gttttgaatt caaggccttt tgaccggtga atggtcatca gctgaacgcc 1254001 atgttcatcc gttctgtttt tctcagcggc cctcatatgg tctacgtggg caagaaagtc 1254061 aggaatcgtt ttgaacttct tggcgacaac cttgatgtcg cgcaggtcat cagagccttt 1254121 ttccagcttg ttgccctcat tgccccgctt ttttaaatac tcggagaagc ccatttttcc 1254181 ttctgcaaag gtgatggctt ctacgggttt cattgtgcgg aggcttgcaa aaaacggtac 1254241 gattttcttg attttgtcca gctggaatgg cttcagatca ggcaatttgg ccagcgcttt 1254301 gatcatggta cagtcctctg taatcgagag cgccttcagc gtattcaaag cggactgttt 1254361 taaaaacaag gcgggaagca agtgtttaat cgcctcggtg tcatcctcat tttggctggc 1254421 gtacaagtag gcgagaatct ggcggacgat ccgtctgctg taaaacgatt ggacgccgcg 1254481 gtcagctgta tacggaattg acgattgatg aagcctttca tatatagcac ggcctccgct 1254541 gtttgtgcgg taaagaaccg caaagtcttc tggactggct ccattttgaa ttttttcttt 1254601 gatatcggaa acgaccattg tggcttcttc ctcttcatca taaggataaa acagcacagg 1254661 gacctgaatg tcatcgcggg ccgcttcaag cgttttggca tatctgtttt tgttcttttt 1254721 cacaacgata tcagcactag agacgatcgg gtgcgtagac ctgtagttcg cagttaaata 1254781 gatcgtcttc gctcccggat aatccttttg aaaatcaaga atgaaagacg gattgcttcc 1254841 gcgaaacgcg tagatggact ggtcatcgtc tccgacacag cacaggtttt gctccgggct 1254901 ggcgagcatt tgcatgattt tgtattgaac cggattaatg tcctgaaact catcaattaa 1254961 gatatacgta aaccgagatt gatattgttc cagaaggtca ggccgctcga taaacaattc 1255021 atagcaggct gaagccatgt catcaaaatc aaattggctg tgttcttttt tctggcgttc 1255081 ataatgttca tataaacgat aaacttgttt ttcccactca tcttttagag ggatgcgttc 1255141 atttgggaca taagtgtttt tccaaaaacc gatctgctgc agggcttggt caactgggga 1255201 ttctttctca tcgatgcctt cttcatagag tgcttttttg atatattgtt cccgctgcca 1255261 ctccattttc agcagatgct caccgttcca tttagcagaa ttagagtgat acaagatctt 1255321 ataaaacaga ctgtggaatg ttcctgtcac aattcttctg acttttgccg gctgtaatcc 1255381 gtactggttc gccatacgct ctttcatttc agcgacagct tttgttgtaa aggtgacaag 1255441 cagcatattt tcaggcggta tgcctaagtg ttcgatcatg tgggcggcac gggctgtcag 1255501 tacccgtgtt tttccgctcc ccgcacctgc aagcacgagg agcgggccct ctgtttccgt 1255561 gacagctttc agctgatccg tgtttaaacc gacagacgga aaaaggctcg tatcgggttc 1255621 tattgttttt ggcacaaatg gtgttcctgg tttaatgctt ctaggacggt gccattctgt 1255681 aacagctggg gacgggtcag cggcgatcgc ttttcccttg ggtaaacgaa tgacaccaga 1255741 ttcctgatca tcttcttttt tcccctcttt agagggcttc ggttcgcacg cctcctcaca 1255801 tgccggaaaa tcgcctggct ggcgatggat aaactctggc ggatcggcga tgttaagccg 1255861 taacaaaacg ggctttccgc aatgagaaca aaataaatgt ccttttattc cctcttcaaa 1255921 gaggaattga taatgttctc tcgaatatgt atgtaaatgt atgattctat cattcagtcg 1255981 ggcgcatttc aaaaaggggt cctcccaatc aaaaggtgtt cattacagac aatgactatc 1256041 atatcaaaag aaatgtgttt caaaaagtaa gtttaaggga aaagagacag cagaggggtg 1256101 ggtattgtat gatatatgca ggtcaaattc agaaccagca atacgctcaa tatgctaata 1256161 gaacgattgg acataagcag gattatgccg gaaccgaaaa aatcagctat gtcccgtttc 1256221 agcgggtata caaagaactg gaaaagcagc aggagaatca aacggcagct gaaagaaaag 1256281 taaacgagat gaaacgtaag cgctctcttt ataagagatt gcgagaaaaa ggaatgggga 1256341 catatattaa tcgatatgta taaaaaaccg ttcataccag agaacggttt ttttatatgc 1256401 agtaaaaatc cggatctcaa aagatccgga tgcgttcagt ccttcatcat ttgtaagtgc 1256461 ggaatgccgg catcgaggaa ttctttttca gaaagcacgc gatacccgtg tttcttgtaa 1256521 aacggcacag cctgtgtttg cgcgtttaaa atgaaaccgg aagcgcctcc gtctgccgcg 1256581 gctttttcga gcgctttcat aatgatgccg ccgacaccgg ctgagcggtg gcttttcagt 1256641 acgcaaatcc gctctaactt gccgtagccg tccttcatgc gccatcttcc ggcaccgaca 1256701 ggcttttcac cgtcatacac gacgatatgc tctgactcat tttcaagttc gtcaatttct 1256761 tcttcagcag gcacgttttg ttctttgaca aagacttctt ctcttacata gaatgcatct 1256821 ttcagttgtt cttcattttt tgcgataact gctttcaaac attattctcc tctgcctagc 1256881 aagaaggttt catatactgt ccacgatccg ttttccaact ggtagagcaa gtggaaacgg 1256941 tcaacgattt cttcatgcga cacttcctgc atttttaatt gtcccagcac atctgaatgc 1257001 tcatcgtcgg aaagattttg gccgaccgtc acatgcggaa cgaaattata ttcctgttct 1257061 cctgccaaca caccggtgta tagcttttca ttgagtgttt ttaactcttc cgtcggttct 1257121 gctttgatgt aaatgacatt attgacaggc gcaaatgagc tgtattttgt cattttgaga 1257181 acgagtgggt gggactcttt tgcgatgttt cttaaatgtg atacgagctg atccgctttc 1257241 tcctccgcgc attcaaagga tgctctcagc gtcaaatgag gcgggattag agagtagctt 1257301 gggtcatagc gctttctgta agagtttgca aggtcttgga gcttttttga tggaaataaa 1257361 acgattccgt atttcatatt atgtccctcc tggaaataaa gtatgataga gtgttaaagc 1257421 atttttttca gcgccggggt gatgagcggc tgccagtatg tccatttgtg gtctccgtca 1257481 aatggctcga aatcataatc ggaaagcttt ttctccagca gctgtttcag ctcccggttc 1257541 ggttctgtaa agtccagaat gttcccgtct gtcgtgtgga cgtcagtttc ttttgttccg 1257601 atttggtgat aaatagagag gtgtttgata tcgtctgact gttttacggc ttctagtacg 1257661 tgtttgtcaa catagggaga ctgcatgatg atgttgccaa acatattcgg ataatcaagc 1257721 gctgtcataa gtgacacggt tgctccgagc gaatcaccga tcagcgttcg gccgtaaccg 1257781 atctgatagg ttggatactc atcatctgca aaaggaacga gctcatgggc gatgaaccgt 1257841 ttataagccg aaaattttga accctccgga tgataagtgt ttctgcgctc ttttacatcc 1257901 ttatagggaa caccgataat aatgctccgg tctatttcgc gtttcgacag caattcctca 1257961 acctgtctgc cgattctccc cagcctgaaa taatcgtggc cgtcctgcgc gataatgaca 1258021 tggtatttat aaagcgggga gtagttggac ggcagataaa caagcaaggt catttcctcg 1258081 ttaagctctt ttgaaaagaa tttcttttct tgcactgtgc cgtttttcgg tgccataaaa 1258141 acattcctcc aggacatcac tatactttct tgcattttca attattgtac catgaattat 1258201 tagaaatttc tctctttaaa cggttcggca cacgaagaaa aaagtgttga aataaactgt 1258261 gaattgcgct aatataaaac aatcagaaaa ttgaaatcga tatttcttat cgtgagaggt 1258321 ggagggactg gcccttagaa acctcagcaa ccggcttgtt ttgcatttgc aaagcgccaa 1258381 ggtgctaaat ccagcaagcg ttttttatgc ttggaagata agaagaagcg ttaaacccct 1258441 tcttcttatg aagaaggggt ttttattttg aaaagggaag gtgtcagcta tatgtcacag 1258501 cacgttgaaa cgaaattagc tcaaattggg aaccgtagcg atgaagtcac gggaacagtg 1258561 agtgctccta tctatttatc aacagcatac cgccacagag ggatcggaga atctaccgga 1258621 tttgattatg tccgcacaaa aaatccgaca cgccagcttg ttgaggacgc gatcgctaac 1258681 ttagaaaacg gcgcgagagg gcttgccttt agttcgggaa tggctgctat ccaaacgatt 1258741 atggcgctgt ttaaaagcgg agatgaactg atcgtttcat cggacctata tggcggcacg 1258801 taccgtttat ttgaaaatga atggaaaaaa tacggattga cttttcatta tgatgatttc 1258861 agcgatgagg actgtttacg ctctaagatt acgccgaata caaaagcggt gtttgtggaa 1258921 acgccgacaa accccctcat gcaggaggcg gacattgaac atattgcccg gattacaaag 1258981 gagcacggtc ttctgctgat cgtagataat acattttata caccggtctt gcagcggccg 1259041 cttgagctgg gagctgacat tgtcattcac agcgcaacca agtatttagg cgggcataac 1259101 gatctgcttg ctggacttgt cgtggtgaag gatgagcggc tcggagagga aatgtttcag 1259161 catcaaaatg caatcggcgc cgtcctgccg ccatttgatt cgtggcttct gatgagagga 1259221 atgaagacgc tgagcctcag aatgcgccag catcaggcaa acgcgcagga gcttgcggcg 1259281 tttttagaag agcaggaaga aatttcggat gtgctgtatc ccggaaaagg cggcatgctg 1259341 tccttccgtc tgcaaaaaga agaatgggtc aatccgtttt taaaagcact gaagaccatt 1259401 tgttttgcag aaagcctcgg cggggtggaa agctttatta cataccctgc gacccagacg 1259461 cacatggata ttcctgaaga gatccgcatc gcaaacgggg tgtgcaatcg gttgctgcgc 1259521 ttttctgtcg gtattgaaca tgcggaagat ttaaaagagg atctaaaaca ggcattatgt 1259581 caggtcaaag agggagctgt ttcatttgag taaacacaat tggacgctgg aaacccagct 1259641 cgtgcacaat ccatttaaaa cagacggcgg aaccggggca gtcagtgtac cgattcagca 1259701 cgcctcgact tttcaccaat cttcatttga agagttcggg gcatatgatt acagccgctc 1259761 tggcacgccg acaagaacag ctctcgaaga aacaattgcc gcactggaag gcggaacaag 1259821 aggatttgct ttcagttcag gcatggctgc catctcaaca gcatttttac tgctgtcaca 1259881 gggtgatcac gttcttgtga cagaagatgt atacggcgga accttccgta tggtgacaga 1259941 ggtgctgacc cggtttggca ttgagcatac gtttgtcgac atgacggatc gtaatgaagt 1260001 ggcgcggagc atcaagccga acacaaaggt catttatatg gagacgccat caaatccgac 1260061 acttgggatt acggatatta aagcagttgt tcagcttgca aaagaaaacg gctgcctgac 1260121 ctttctggac aatacattca tgacgccggc actgcagcgt ccgcttgatc tcggcgtgga 1260181 tattgtactt cacagcgcga caaaattctt aagcggacac agcgatgtgc tctcaggttt 1260241 ggctgctgtc aaagatgaag agcttgggaa gcagctgtat aagctacaaa acgcgttcgg 1260301 cgccgtcctt ggcgtgcaag attgctggct tgtcctgcgc ggattaaaaa cattgcaggt 1260361 ccgtttagag aaagcgagtc aaacagctca gcggcttgcg gaatttttcc agaagcaccc 1260421 ggcggtcaag cgcgtgtatt atccgggact ggctgatcat cccggcgctg aaacccataa 1260481 aagccagtca acgggagcgg gcgccgtgct atcttttgag cttgaaagca aagaggccgt 1260541 taagaagtta gtcgagaatg tgtcactccc agtcttcgct gtcagccttg gcgccgtgga 1260601 atcgattttg tcctatccgg caacgatgtc tcatgcggca atgcctaagg aagagcgtga 1260661 aaaacgcggt atcactgatg gcctgctccg tctgagtgtc ggcgtcgaac atgcagacga 1260721 tttagaacac gatttcgaac aagcgctgaa agaaattgct ccagtttcgg ttcgttaaaa 1260781 aagaagccgg ggatagtccg gcttctttta ttattgttcg tcatcaggat tcagaatcgc 1260841 gaggacttga tgatcctccc aaacgccatt aatttttaca ttttttcggg cgatgccttc 1260901 tttatgaaat cccgcttttt ctaaaacacg catggacccg agattacggg gcatcacacc 1260961 ggcttcaatc cgatgcagtt tcaattcgtg gaacgcataa tcaacaacca atctgactgc 1261021 ctctgtcata atgccctttc cattatgggc tttgtctaaa aaatacccga tgaacgcagt 1261081 ttgcagcgcg ccacggatga tttgaaagag cgaaaccgtc ccgattaatc tatcgtctga 1261141 cgctgtaaag atgccaaaat gatattcttc atctttctca agtctttcct gatactcggt 1261201 tattcgtttt ctttgcccct caaccgtata gtaatcgtct gcgcgtatca tagaaaactg 1261261 ttcgaaaaaa tctcgatttt cgctttgcag ccccagattt tcttcggcat ccgttacttc 1261321 taaaggtcta acataaatgg tttttccttt taacatatag tgatctctcc gttctcatgt 1261381 cagcattcct cttacattat tctcagggaa atgcaaatat cctttttata agaaggaaga 1261441 aaaccaattt cccataaaag tgccaacata gttgccgatt aagtagccga gcgtaccgac 1261501 aagcatgatc ggggcgacaa gctcccgcca tcccttggca attgccatcg cagccgcagt 1261561 cgtcggtccc ccgacagtag cgttgacggc gagcagaatt tcttcaagcc gcacacggaa 1261621 caattttccg gcagctaagg aaaccgctaa attgctaatc gcaatgataa acacgaataa 1261681 tagaataaga ggcgcattcg tgacgattaa gcggagatct gcaggaatgc cgatcaccac 1261741 aaaaaacaaa taaatcaaaa aggttccaag ctcctgagat ccattgagcc tttcaaaaaa 1261801 acgcgggaaa agaaaaatga taagaacagt taaagacgta agaaccaggt actgatcgcc 1261861 aagcgtaccg gtcagcaggg gatgagaaaa aatgctttta aaataaccgg aaaccttcat 1261921 actaaccgca acaagcgcga aagcggcacc ggcattaaaa gcgatatcct ttaaggaaat 1261981 atccttccgt ttccaatagc tttcagcact gtttccgctg tttccatcgg cttttacctt 1262041 ctcttcaaac ggcatggcat aatgccgctg aaaccatttg agtgcaggaa tgctgattaa 1262101 aataaaaaac aaaagcgcca tcataaaatt atcagccaca acggtagccg acacatattc 1262161 accaggcgtc tcaaattttg ccgccatcgc cgcaaagttg accccgccgc cgatataaga 1262221 ggcgctgatc atcccaccga ttttatctaa gtaaggaata tgctgtttga gtagaaaaaa 1262281 agccaggata ctgccaagca ctgttccaac ggagctaatc agaaaaataa acagcaaacg 1262341 cctgctttcc ttaaaaattt gcctaacatt gatctgaaac aataaaagtg gtatcgccag 1262401 cggtaccaca taagaccaca cagtgtcata cacgggcgac tcaacaggaa gcactcctac 1262461 atttgtaaac accatagcac ctgcaagggc gataatagcg cccgacacag cagacgccca 1262521 cttaaagcgc tgctccagcc cgatgctcac tgccgcccac accgcaataa acccccataa 1262581 tacccataca tcatcagaag aaatcaaaga atgcaaaacc ccatcacctc tattgttaga 1262641 aaattaagac atattataat agccggggaa cggaacagca agtccaaaaa aagtttttct 1262701 aaaaaagcag ttgacgaata gaaggtaagg ttatataata gaacttgtca gaaagataac 1262761 aacataccca gcaacacata catatcatga ttccgtagct cagctgggag agcgctacct 1262821 tgacagggta gaggtcgctg gttcgagccc agtcggaatc atagcttaaa cccttgcgca 1262881 gcaagggttt tttactttgc gttaataaag ccggttcgtc aaattcgtga gttgttggcg 1262941 aactgttggc gaaattcatt gaccgcagtc caaaaactac ctccaaactt acttgattag 1263001 ttcaatagta acaaacggaa gatcggattt ctgttaaatc ttcattgaga atagccagtc 1263061 caagaccgtc acttcagcca tgcatctttt aaatgaaatt ttgtactgaa aacatcaatt 1263121 gtatttttaa attctgctct agaatcagcc cctttataat aatcttgata aattgcttgg 1263181 ggtgatactg attcgtgatt tgtgctatgg tttgcaaggc ttgtagcaaa agcaggagca 1263241 acagtaacga gtaaagcaag ggataatgca aaaccagtta aagctttttc aatttcattt 1263301 taagcacttc tttttttaaa atacaacttt attattaaat ggaatacaaa aacatccaag 1263361 gtgttttttt gttagtaagt tgagttaggg ggattggatg gcacttagaa tattgtttct 1263421 gctgatggga tgttgattct ggatatattt ccaacacgat tacaggccgg acatgaaagc 1263481 gaaccttgct ttgatcgggg caatcatttc atttacggct gcggtttact ttaaagatat 1263541 tgatgtattg agagaagagg gaaaacaaat gaacggaatt tctgagcgtt ggaacacgtt 1263601 taaattacaa aaatcccctg aaccactcta gatcagggga ttgctttccc aacagcttat 1263661 taagtagcgg aaggcatgat caacgattta gtatcaattt attaattgcg aatactagaa 1263721 acataccgtt ttccgccttc cttagaagta acatattctc gaggaacatt aagtctattg 1263781 gtagaatgat aacttacata aagtttcata tttgctcggc tcgttacgat agccgtatga 1263841 tccatccaac catcagcata gcgaagacct attttattat ggtaatcata gtgatataca 1263901 tctccaagct ttacatttga atatgtatca gaaacagtct tcatttttat tccgccagct 1263961 tttaaaatgt atgatctaaa ggctcctgca ttaacccaag catctgtata gggtttccat 1264021 tctttaaagt acggcattct tccagctctt aatgcttggg aaacaaagtt agtacaatct 1264081 ttgtctttat aatatttata gtttttattt ggttttaagg catatttttc tgcatatttc 1264141 attgcagcgt aaccactata tcctttaaca gatgttgcag tcacagttag ttgattagag 1264201 ttagcagcat tgaagttcat acttactggt ttatcttcac ttttcacttc ttctttatca 1264261 tcatttttca cttcttgctt atattttttt aaaaattcat ctaatttaac atccgaagaa 1264321 tattcttcat cattttcata ttgtagagtt gaagaagaat tatttaattg tgttacattt 1264381 agttgcttag aagaattact caatggtatt acatttagtt gattagaaga atttttaact 1264441 tgagagaaac ttagattaga agtatttgtt gattgagaac tttgtttatt agaagttgtt 1264501 ttgggaattt caagtttaat attatcgccc agagatgttg ttactttttc aacaccaaaa 1264561 acaaagtttc gagtaatata agcttcaaca attagcttat tgtttttttc agaagtctta 1264621 acatcgtcta tatcgtatgt aaactcgtgg aatttttgtt tgtccacttt acttaacgca 1264681 gaatacagta agactccttc gtcggaatca gtcaatttag actctttagg atgcgctaaa 1264741 ggagtgttgt gttcaaaatc atatttttgt tgttctaaca tatccttaac tttttcgtaa 1264801 ccaatctcgt tggtaattga aacattttct ttagtctctt tattagtagt ggctgcaaaa 1264861 acttcatttg ttgacactaa tggtgacaat gatagacata aaactagtga agcaagtaat 1264921 tcttttttca tacgaaacct ccaataaaat ctaaatataa gtaatattta tcatttacac 1264981 caattgaaat atggcataaa atacatgtaa taatataaca taaaaataaa tacataaaaa 1265041 ggtatcggag gaaaaaatga aaaagaaaac taaaattata ctttctctct tggcagcact 1265101 tattgttata ttgatagtac ttccagttct atctcctgtt gtctttacag cttcttcgga 1265161 aaaaggagca atcagacacg aaatttataa aagaggatat ccctaccaaa gctactttgc 1265221 agttctccag aaaagagaag gagacaatga atctgggaat ctttattatg taaattggct 1265281 agattggaaa gatgaaacag ggcaaactcc tcacttatgc tattcgaaaa aatcatcaga 1265341 tggtgaatac gaagtaagtt gtggcacagg gccgtaaaaa taaattttaa aattgaataa 1265401 gtccaagacg gaaagcctgc ggacactgat cgttttacag agaaatttgt gcttcgatcg 1265461 gtgtccgttt tttttcgcaa ctaaccagat gtctatcgcg attactagct atgaaaggag 1265521 taattagaca tgaaacagtc caaaaagaaa ccatcacaga agcaacatga gcgcttagat 1265581 cgtttctggc aacaaatgat gaacactaac atgcaaacac tcagacgtgg caaaggcggc 1265641 gcttataaac gcagaaagta aaaagggagt ttgaggatga tgaaaaacgg attcgcttat 1265701 aaaaacggaa agcttgtgaa tatcttttgc ggcaaagaag agctctataa cgagttgaaa 1265761 gccttcttgg tcaaaacctt cagtatcaac gtgaaagagg tatcgaggcc ctcaatatat 1265821 cgcagaacaa aaagcaaaca actggaatga cacttactct atttaactat caggagggaa 1265881 agcactatga cagatcaaat gattgcatgg gagattgagg aatggattcg tgattataaa 1265941 ttcatgctgc gggagatcaa aaggctcaac cgtgtattaa acaaagtgga ttttattagc 1266001 acaaagctca ctgcaacata cggggaggaa gcgggcatgc caaggggatc agcaggcgtc 1266061 agtcaggcag aattgcggca gatggaccga agagaaaggc ggcttcacaa atatgaatct 1266121 attgtgcatt acctggacaa tgcaatggaa cacattgaag aagaaaagca ccgaatcgtt 1266181 tacgattgca tgatggaagg catgagctac actgctattg caaaccacct tgattgctcc 1266241 cgggatacca tcagaaagat caaaacagcc ataatcggca acatcgtcaa taaagtcaaa 1266301 gaagccaact ttctgcaata tttgaattcg tttaaatcgg cggtgtaaaa tggggggcag 1266361 gatcggcgcg gcggattatt cctgcgtcac caccaatttc atacaatgag taaaacctcc 1266421 cagtggtaag cgaggatcaa ctcaactggg aggtcttaca tagtgaatcg gtgataaaac 1266481 agcagcagta ttgcgtacat gttaatatcc ccgacaaaat atgttttttt caacagattc 1266541 gttcgacaaa ttttgcaaat tgttaatcga taacttttca ttcccgatat taaaaatggg 1266601 agtgaattgt aaaatgaaaa aacagaaaaa taataaaaag aagaatattg aaaagcgaaa 1266661 tattgaaaag cgaaatattg aagagaagaa taatgaggac ttagaagaac tggaaaatgc 1266721 gatttatact tatcacaaaa aggagctact tgctttcttt cttgaaaaaa ctcgaattgg 1266781 tcatgataag gaagaataca aaaggttcca atctcttctt tataagttgg atattgaatg 1266841 tttagaattt gctatatcga gattttctca tatagatatt atccatgatc attcaaaata 1266901 tgttccagcc tttatccctt tatttgcagc atatctcacc atgttcttta atttttatga 1266961 aaaacattgg ggagctttat cttttgctgc tggtacaatt gctgctattg tttggataat 1267021 tgcagtagaa agaaaacata gaaatcaagc aatttctatt atgaaaatat ttgaacaagt 1267081 caaagagaga aaagtgaaag acagatctaa agactgaaag gagaaaatat gaataaggat 1267141 aaattaaggt atgcaatctt aaaagaaatt tttgaaggta ataccccttt gtcagaaaac 1267201 gatattggag ttactgaaga tcaatttgat gatgctgtga actttttaaa acgcgaaggg 1267261 tatatcattg gggtccatta ttcagatgat agacctcatt tatacaaatt aggacctgaa 1267321 ctgacagaga aaggtgaaaa ctacttgaaa gagaatggaa catggtctaa ggcctataag 1267381 accattaaag agattaaaga ttggattaaa taataagagc atcctgcggg gtgctttttt 1267441 tgttccctgt aaactgcttc cggtaagtct caggatagac aattggcggt taacggcttg 1267501 agcacggtgg tggtttagag ggaatatctt ttccaaaaca acacgaatca gaagggggcg 1267561 gcggtgaatg tagatggccg aaaagcacat tcaggcgtat aaggattacg tcaaaggcat 1267621 gaaatacaag gaccttgccg agaaatacgg ggtgtcagtg aacaccatta aatcgtggaa 1267681 gcagcggcat ggttgggaaa ggaaaaaggg tgcacccatt gaaaaaagtg tgcacacaaa 1267741 aaaaggcggg caaccgggca acaaaaatgc attagggaac aatggcggcg caccacagaa 1267801 gaatcaaaat gctgtgactc acggcttttt ctctaaattc ttgccagaag agacgcttga 1267861 aatcatggaa gagattcagg agcgttcgcc agctgatatg atatgggatc agatacagat 1267921 tcaatatgcg gccattcttc gggcgcaaaa gatcatgttc gtttctgata aggaagaaat 1267981 gatcaaagag ctgaaaaaga aaaggtccct catatctgag gtcagcgaaa ttgaagatgg 1268041 gcttgtcatt agttttagta cgtggtttcg ctacagactt tacagtgaaa caaacaccta 1268101 acacatttca cattgcttca gattgccttc aaacttgata atataacttc taaaccttcc 1268161 tataaaatga aggtttttta tttgatttca atttttaaat cctttacata cagcgattga 1268221 ttaactcgag caatcaatgt cgcagttata tttatttttc aagaaaatgt tataatgaaa 1268281 agccataaaa tgatgggagg gggaatttcg atgcattaca taacggcatg tttaaaaatc 1268341 atcagtgata aagaccttaa tgagataatg aaggaattca aaaaacttga ggaagaaacg 1268401 aacaaagaag agggttgtat tacattccat gcttatccgc ttgagccatc agaacgtaaa 1268461 ataatgcttt gggagatttg ggaaaacgaa gaagctgtga aaatccattt cacaaaaaaa 1268521 cacacaatag acgttcaaaa acaagaatta acggaagtag aatggttaat gaaaagcaat 1268581 gtgaatgatt gaaaggctct ttaaaaagag acattcaatg acttagtatc agccacttgt 1268641 gactaagtag taaattgttg tccaactctt attttttcta tttaatattt tttgagacga 1268701 aaatgttttt ttaagctgat tttaaaatgt attcaaagtc agctctgttt gatttaatgg 1268761 attatattat ttggatagct tgttaccatc ataatggaga tactccttat aaattggagg 1268821 ttaaaataat gagtcattct caagaaaaaa ttgcactaat tacaggagca agcagtcaag 1268881 gggatattgg tacggctatt tgtcgtaagt tagcctcaca gggtatacat atcttcttta 1268941 ctcactggaa ttctgatacg gcctggatag aagaatttca acaagaaatt ttacgtatgg 1269001 gtgtccgctg tgaggcaatg aaaattgatt tatcagatgc acatgctgca ttcacaatac 1269061 atgaaaaaat ttcagataaa ttaggatatc cttccatcct tattaataat gcagctcatt 1269121 ccgcaagtga taattatgta tcgttagatg ctaaatcact tgatgagcat tatgcggtta 1269181 atatgagatc gaattttctt ctttgtgttg aattcgcccg tcggtttaaa aaatctaatt 1269241 taatatcagg aagaatcatc aatatgacat cagggcagga tttaggtcct ttgcctgggg 1269301 agttagcgta tgcagcaact aaaggagcta tttctgcatt tactaggtcg ttatcacaag 1269361 aacttgcacc attgggcatc actgttaacg ccgtaaaccc aggtccaaca gattctacat 1269421 ggatgacaga tgaaataaga aattttcttt cacctaaatt tccaatgggg cgtattggca 1269481 caccagatga tgcagcacga atgattgcct ttcttgcaag tgatgaggct gaatggataa 1269541 ctggacaaat tattcattca gaaggtggat ttattcgggg ctaagctaat gaaacacggt 1269601 atacaccaat gtatgatgta ttcccaaaac taaatctaaa cttgaagcga aaataaggtc 1269661 ccttctcttt ttagaggggg accttatttt attcatgcat gttttgcatc cagaaaatct 1269721 ggcggataaa gattaataaa ccgttacata tacttttccg aatactgcag tacctttaaa 1269781 caaagtaatc gtggctttcc cttttgattt agccgtcact aaaccatttt gatcgacttc 1269841 agcaactttt tggttatcag tccaataacg agtagctgaa ttatttttaa cagaataggt 1269901 ttctccaact tttagaggta aattatagtc ttgaatcttg ataacatgtg taggtgaaat 1269961 agaaatgttc tttacttcag taggtgtgga gtttatttca tgagctgaag ctaccccgct 1270021 gaccgacaga gctaacgcag aaatcgataa agcagaaaca accgtttttt tgaaattcat 1270081 tttgaaacac tcctttaaag ttttttgtct tgcactataa caattcaata aaagtaatta 1270141 ttttccttgt aaataaatgt taataatatg tgaacgatca attgatttga gctaagaata 1270201 ttgtgtgccc tgcacagagt ttgtatttat gatggaaaat tgctgagaga gaatggccat 1270261 ccttaaaatg ttaatagcac acatttgatg ggtattagtt tgttgagcgt gtggaaattt 1270321 tgttacctgc actttatccc cgaagatacc aaatcacttt tcttcatcat gttcttactt 1270381 tcgtactcat acattagaaa atcttcgttc taaataggtg aagaattgga gtatttttat 1270441 gaatttctgc tgaatataca ttacatagca aactcaaaga gtataaaaat cgcttttttc 1270501 cggaagcttc ggtaaaaaac gaaacttttg tctctatgat tttgttttat aatgtaaacg 1270561 gtttcttata tagtatactt atactatcaa tttgctcaag tagatactga caggaaggat 1270621 agaaaaacag atggaataca taaatacaag acaaaaagag attttgtatc tgttgttatc 1270681 tgaacctgat gactatttag ttgtgcaaga tttcgcagat agggtacagt gttctgaaaa 1270741 aacaatccgg aatgatttga aagtgatcga ggattatctc aatgagcatt ctcatgcaca 1270801 gcttattcga aaaccagggt tgggcgttta tttacatata gaagaacagg aaaggacctg 1270861 gctaagccaa caattacata ctgaacattt ttcttctagg cagcggagcg ataaggaaag 1270921 aatgctgcac attgcttatg acttattaat gaatccgaag cctgtttccg caaaagacat 1270981 tgccgctcgg cattttgtca atcgatcttc cattaaaaag gatttatacg cagtagaaga 1271041 gtggctgaag cgttttgatc tcacactggt ttctaggcag cggcttggat taaaggttga 1271101 agggaacgaa agaaataaaa gaaaggcatt ggcaagaata tctgatttga ttcacaatac 1271161 agcgtttacc agccaattta ttaaaagtaa gtttttacat tatgaagtag actttgtgac 1271221 gaaagaaatc aaatcactac aaaaaaagca ttccctctat ttcacagacg aaacgtttga 1271281 aagtttgttg ctgcatacat tgttaatggt ccgccgcatc aaaatgaagc agccgatttc 1271341 attgtcccca aaagaaatgg cggcagtaaa aaagaagaaa gaatatcaat ggacatttgc 1271401 ttgtttacag cggcttgaac cggtttttgc aattcgcttc cctgaagaag aagccgtgta 1271461 cttaacatta catatattgg gcggtaaggt tcgttatcca ttgcagacag aagagaacct 1271521 tgaaaatgct gtgcttccta aggttgtagg gcatttaatc aatcgtgttt cagagctgaa 1271581 aatgatggat tttcacaagg atcaggattt gatcaatggt ttgaacattc atctcaatac 1271641 tgtgctacaa cggctgagct acgatctttc tgtagcaaat cctatgctca atgacatcaa 1271701 aaagatgtac ccttatttgt tccacctcat cattgatgtt ttggaagaca tcaatcaaac 1271761 ttttgatctt catattcctg aggaagaggc agcatatttg acattgcatt ttcaggcagc 1271821 gatcgaacgg atgcagggca gcagcgagac acataaaaag gcggttatcg tctgccacat 1271881 ggggattggg atgtcacaat tgctgcggac aaaaattgaa cggaaatatc accaaatcgc 1271941 tgtaatggct tgtattgcaa aggccgattt aaaggattat atcaaaaagc atgaggatat 1272001 tgatcttgtc atatccacca ttgcgctgga gaatataacg gttccccata ttgttgtgtc 1272061 tccgctttta gagcctggcg aagagaagaa attaagtgcg tttatacgtc agctgggcga 1272121 atcacaccgc caaaaacaaa aaacgtttca gatgctgaac aatacgactc cttttttggt 1272181 ttttttgcag caggaggcgg agcatcgcta caagttaatc gaacagctgg cgacagcttt 1272241 gtttgagaaa ggctatgttg ataaggacta tgcggttcat gcggtgatga gggaaaaaat 1272301 gtcggctaca aatattgggt caggcattgc cattcctcat gcaaacgcta aatttattaa 1272361 acaatcagca atcgcgattg ccacattaaa ggagccgctt gaatggggaa atgaaaaagt 1272421 ttcgctcgtt tttatgctgg ctgtcaaaca cgaggatcaa actatgacaa agcagctgtt 1272481 tagcgagctt tcatatctta gcgagcagcc ggccttcgtc cagaagctga cgaaagaaac 1272541 caatgtcatg acatttttat ctcatttgga ttattaaaag cagggattat tccttgcttt 1272601 ttttgttata gggaaaaatg cctttattac cggaacctat ggtaaaaaaa gcgattttaa 1272661 tgagctgatt tcggtataca gttgagacaa gatcttatta ttcacacttt aaaggaggtt 1272721 tcctatgaaa ctgttagcga ttacatcttg tccgaatgga atcgcccata cgtatatggc 1272781 agcagaaaat ctgcaaaaag ctgctgacag actgggcgtt agcatcaaag ttgagaccca 1272841 gggagggatt ggtgttgaaa ataagctaac cgaagaggaa attcgcgaag cggacgcaat 1272901 cattattgct gcagaccgtt cggtaaacaa agaccggttt ataggcaaaa aactgctgtc 1272961 tgtgggggta caggacggta tccgcaaacc ggaagaattg attcaaaaag ctcttaacgg 1273021 ggatataccg gtctatcgtt ccgctacaaa atcggaatcc ggtaatcatc aggagaagaa 1273081 acaaaatcca atttaccgtc atttaatgaa cggcgtttca tttatggttc ctttcattgt 1273141 tgtcggcgga ttattgatag cggttgcatt aacgcttgga ggggagaaaa cacctaaagg 1273201 cttagttatt ccggatgatt ccttctggaa aacgattgaa cagatcggca gtgcttcatt 1273261 ttcatttatg attccgattt tagccggcta tatcgcctat agcatcgctg ataaaccggg 1273321 gcttgtgcca ggtatgatcg gcggttatat tgcggcgact ggaagttttt atgacagcgc 1273381 aagcggcgcc ggattcctcg gggggattat tgccgggttt ttggccggat acgcggcact 1273441 ttggatcaaa aaattaaaag ttccaaaagc catccagccg attatgccga ttattattat 1273501 tccggtgttt gcatcactga ttgtaggttt agcgtttgtg tttttgatcg gcgcgcctgt 1273561 agctcaaatt ttcgcctctt taacagtttg gctggcgggg atgaaagggt cgagctcgat 1273621 ccttctggca ttgattttag gggcgatgat ctcatttgat atgggcggtc ccgtaaataa 1273681 ggtggcgttt ctgtttggat cggcaatgat tggagaagga aattatgaaa ttatgggacc 1273741 aattgctgtc gccatttgta tccccccgat tggccttggc attgcgacgt ttttaggaaa 1273801 aagaaaattc gaggcatctc aaagagaaat ggggaaagcg gcatttacga tggggctctt 1273861 cggcattact gaaggagcga ttccatttgc ggcgcaggac cctctgcgcg ttattccaag 1273921 tattatggca ggctcaatga caggttctgt gatagccatg attggcaatg tgggagacag 1273981 agtggcgcac ggcggaccta tcgttgcagt gcttggcgca gttgatcatg tcttgatgtt 1274041 ttttattgct gtgattgcag gatctcttgt cactgctctg ttcgtcaatg tactaaaaaa 1274101 ggatattacg gcgtctcctg tgctcagtga aactgcaccg acctccgcgc caagtgaagc 1274161 tgcggcagca aatgaaataa agcagccaat tcaaagccaa aaagctgaga tgtcggaatt 1274221 taaaaaactg acagacatta tcagcccgga attaattgaa ccaaatttat cgggggaaac 1274281 gagtgatgac atcatagatg aattgattca gaaattgtca cgaagaggtg cgctgctttc 1274341 agagagcggg tttaaacaag ccattttgaa tcgtgaacaa cagggaacaa cggcgattgg 1274401 catgaatatc gcgattccgc acggaaagtc tgaggcggtc agggagccga gtgttgcctt 1274461 tgggatcaaa cgatcaggcg ttgattggaa tagcctggat ggatcagaag ctaaattaat 1274521 ctttatgatt gctgtaccga aagagagcgg gggaaaccag catctcaaaa tactgcagat 1274581 gctatctcga aagctaatgg atgacaatta tagggagcgg ctgctctccg tgcaaacaac 1274641 agaagaagca tacaagctgc tagaagaaat cgaataaagc gggggatttt catgacgact 1274701 gaaccgttat ttttcaagcc tgttttcaaa gaaagaattt ggggcgggac cgctttagct 1274761 gattttggct ataccattcc gtcacaacga acaggggagt gctgggcttt tgccgcgcat 1274821 caaaatggtc aaagcgttgt tcaaaacgga atgtataagg ggttcacgct cagcgaatta 1274881 tgggaacatc acagacattt attcggacag cttgaagggg accgtttccc tctgcttaca 1274941 aaaatattag atgctgacca ggacttatct gttcaggtgc atccgaatga tgaatatgcc 1275001 aacatacatg aaaacggtga gcttggaaaa acagaatgct ggtacattat tgattgccaa 1275061 aaagatgccg agattattta tggccacaat gcaacaacaa aggaagaact aactaccatg 1275121 atagagcgtg gagaatggga tgagctcttg cgccgtgtaa aggtaaagcc gggggatttt 1275181 ttctatgtgc caagcggtac tgttcatgcg attggaaaag gaattcttgc tttggagacg 1275241 cagcagaact cagacacaac ctacagatta tatgattatg accgaaaaga tgcagaaggc 1275301 aagctgcgcg agcttcatct gaaaaagagc attgaagtga tagaggtccc gtctattcca 1275361 gaacggcata cagttcacca tgaacaaatt gaggatttgc ttacaacgac attgattgaa 1275421 tgcgcttact tttcggtggg gaaatggaac ttatcaggat cagcaagctt aaagcagcaa 1275481 aaaccattcc ttcttatcag tgtgattgaa ggggagggcc gtatgatctc tggtgagtat 1275541 gtctatcctt tcaaaaaagg agatcatatg ttgctgcctt acggtcttgg agaatttaaa 1275601 ctcgaaggat atgcagaatg tatcgtctcc catctgtaac atggcagggc ttgagaaata 1275661 aatttgcgag tgaagacgcc tattctccag caatgatcta aataaaataa gagtttaata 1275721 gttggagaag aaatgttaca ctcttttctg tatatggtaa agaatgaaaa aacacgattc 1275781 ggttggtagt ccggatgcat gattgagaat gtcagtaacc ttcccctcct cgggatgtcc 1275841 atcattcttt aatatctttt atgaggaggg aatcgttatg aaattaacga tttactacga 1275901 tggtcagttt tgggtaggcg ttgttgaagt tgtggacaat ggaaagctaa gagcctttcg 1275961 tcatcttttt ggcaaagagc cgagggattc tgaagtatta gagtttgttc ataaccaact 1276021 tttgaatatg atggcccaag ctgagcagga aggagtgcgt ttacaaggca ggcgtcaaaa 1276081 aaagatcaat ccaaaaagat tgcagcgcca ggtttcaaaa gagttgaaaa acgccggagt 1276141 aacttctaaa gctcaagagg cgataaagct agagcttgaa gcaagaaagc aaaagaaaaa 1276201 acaaataatg aaagaacaac gagaacatgt aaaagagcaa aggtatatgc tcaaaaagca 1276261 aaaagcgaaa aagaagcaca gaggtaaata atccaaacaa aagcaggcgc agtgcctgct 1276321 tttgtaatta aggactctac tttgtaacat atatccaatg tttatactcc gctgatttat 1276381 gattcaatat aaaccctaac ttctccaagg ttttttgtga gcctagatta tcatgttcgc 1276441 atcttgcggt gatccgggat actgtttctc ggcttaatgc ccagtttatt agtttttggg 1276501 cggcttccac acaataacct ttgcggcgat gacttttatt tgttgcaaaa ccgatttcaa 1276561 tcatgccatt ttcgtctggg tcacctaaaa atccagttcc cccaacaatt tcataattgt 1276621 ccttctttac aataatccat gaatcaaatc cttttgttcc attgtttttg actaaaatct 1276681 cgcggaaata aggtatcgct tcaaaaaaat cagaatttgg ccattcacca tttgtttcat 1276741 agcctaattc tttgatagcc tgatgatctt gtttagacgc ggcgtcaaga aggggaatat 1276801 caatcgtttg taatcgtaat cgattcgttt caaggagaac catatattta atcctctttt 1276861 ctttttactg ggaataatga taacatataa caattttctc tggtaccttg gcagtagaga 1276921 aagatgaaaa aattgagggg gattgaaaga gtgacaggtg agagtttgcc cagaccaaaa 1276981 acgggtagga aaatgctgat gttaatgtgt ccctacccgt ttttctgttc ctgaatgcag 1277041 ggtttctgat aacatgttgt gctacctttt cgcaatcaaa taaagcgata tggctctttg 1277101 ggtttgcaca ggattatgaa tgataatgac ccattggttt cttcgtcttg gaaagcttgc 1277161 taccgcatac aatggagcag tatcgcgcgg agtgaaccca ccatttatca cgttgatatc 1277221 tcttccttca agatgacaaa ctaagtattc acctggattg atgacctgtt ggttcgtcca 1277281 tgcgtaagaa taaaagccgt ctccaagatc ttcggtggaa gatgggggga caaagccatc 1277341 tacagtcaat gtgatttctc ttcttcgctg tctttctgaa aagtctggac ttctttgagg 1277401 gttatgagta tgtgaaaagt aaggaattaa cgcagggcca taaaagtaat gatacaaagc 1277461 aaccactcct ttattttcca ttcatacaaa ttgtatgtgg gagttatttg ttcattcctg 1277521 ttttgttcca tgtagactaa taatgggcta taggcgtcca aggaaatcaa tttgtccttc 1277581 cgttgattca atgctagtaa ccttgaaaat gcaggttagg atgatagaat ttacatatta 1277641 ctgcaagaag ttagacatac atcattttga tagtgggtga aaacaatggc gaaaaaaatg 1277701 gcaaaaacaa atgcggttcg tctgatagaa cagcagaaca tctcttatga ggtattaggg 1277761 tataaaacag acggccagcc ggtagatggc atctctgttg cggaaaaaat cggttattct 1277821 ttgaaatatg tatataaaac gttggttgca gcagcaggaa caaatcatta ttatgtcttt 1277881 gttgtacccg ttgcagaaga gttagatgta aaaaaggcag caaaggtgac aggggaaaag 1277941 aaaatagaaa tgattgcaat gaaggagctg ttagcggtaa ctggctatct tcgcggcggc 1278001 tgctcgccaa ttggcatgaa aaaattgttc ccgacctata ttgatgcatc tgcagaaacg 1278061 cttgatttta ttattgtcag tgcagggaaa atcggtatgc agctaaagtt ggcgccacaa 1278121 gatttagcca gatcatgtga tgccgcattt gcagaaattg tatagatgca gatatagggg 1278181 aacgaaaaag cttagtcata tcgattaagc tttttccgca tccctttcaa atatgatttc 1278241 aaaataagca gctgccccat acccatctat actgggagcg aaaatctgaa cgaatctcca 1278301 gcctcttttc gcataatcat ggatgatttg ctggtagtct tctttaggcc ttcttctcat 1278361 cgtactcagc tcaactctta cgaattcata ttctttcatc gtttgatccc tcctattaag 1278421 gtatacgtaa aatggagcga gaagttccga aaacctaggt taaggtcgga aagtatattt 1278481 cactcactaa acaaatccat ttatgcctga tgcctgcatg catctgggaa gagttaaggg 1278541 gctataaaaa cgaattttac cgggtcagca gtccaaatga atctcttgct tattgcattt 1278601 gactgagtat ataagtaaaa aaagagcggc cagaacatat aagaaggaga tgatcattaa 1278661 cgcactcata acagggtagt gtttagcgga gtagatgaaa aaatcaagct gtgaaatttg 1278721 tttggggctg ctgacggcat caattccatt aagcagtttt gagagtttag cagtatagtt 1278781 ccaatcaaat cgatctgaaa caagctcgct tccttgatac caattaacag cagctaaaaa 1278841 cagaaatacc ataatagaaa atccaagctg aacaactaaa aatattccct tcacttttgt 1278901 atgacctcca aatctatgaa tatgggaaaa tcaaacaata tattaccacc gtatgggtta 1278961 ttcttgcaat ttcacttcca tacaactcaa acgcaagtct atttttttgt ttgtttttgg 1279021 cttataatac ctgatgatgg aaaaagagtg cgggtttata gattagagaa acaaatgtat 1279081 ttcttagcat tttttatttg tggagagagt atagaagcat tcgattagat ctgctttttc 1279141 acagaaacgg ttttcatctg tttgcctgag ctttacaatt ggctggcaaa aaaacaatga 1279201 tttctttcaa tcaaaacatg caacgatgcg acacatttta tatcttgatg acttatttca 1279261 ttgcctttaa gtcatcctat cgagaaagcg atggtatttt atgaacaaag aaaccctaaa 1279321 aaacatactc atgatttttt caatatgcgc aacactccga gaaaccgatg gtatgcgcat 1279381 agctgatagc tggattttga gtgagattat acgatttttg atttgcatgg ttgtgttttt 1279441 tgccatgaca tttctattag atgctgtttt tccaaacaaa aaagagtcac attaatgtgt 1279501 ggctcttttt gcatcatctg atcagaaaca tcataaatga atcgatcatc atgatgaaga 1279561 acagcaagca aaaataaata agcgagtaga caaacatatc ctttgcccac ttcacgtcat 1279621 cgtctgtttt gaatcctttg atgctttttt tgatccatat gcctccgaga accaaggcgg 1279681 ctaagaaata aaatgggctt atatggccgg tgccgagaga gaaaggaaat aatagcgtga 1279741 ccggcaccag gacggcaata tattgcatca tttttatttt tgttacatga ttgcctttga 1279801 ctactggcaa gagcggaacg ccagcagcgc gatattcctc tttgcgtctt atcccaatcg 1279861 cccaaaaatg cggcggctgc cacagaaaca taatcgtgta caacagcact gctgtcatac 1279921 tgaagtcacc ggttacggca caatacccca tcaatggcgg cgcagctcct gggaagctcc 1279981 cgacaaatgt gctccacaca gacgttcgtt tcacccatac cgtatagatg atcgcataaa 1280041 aaataaaggc ggccagtccg agaaaggccg ttaatggatt gagggaataa agcatggcaa 1280101 gacctgcgat tcctaaaaca gagccatatg ttaagatcat ggctggcggc attttccctg 1280161 tgaccgaggc cctgctgcga gttcgtgcca tttttgcgtc catatgccga tcaaaatagt 1280221 tgttatagac agtgccggaa gccatcacaa acgcggttcc caacattgct gttaccattg 1280281 tcatcaaaaa agccaagccg gttaacgttt tttctgcgct tgcaaacgcg atccaaaacc 1280341 cgccgaaggc tgctatcgag tttgatatga taatgcccgg ctttgcaagt ttgataaaat 1280401 cgtaaatggt tacccggttc gaagctttta tgtattttgt ttcagatatg gctgcagaat 1280461 ctcttgtatt ctccaaaaat agacgcctcc cccaaaactg catgcttttg ttatcgtaac 1280521 aagaggggga cagaatcaca attatttccc atatttgtca tgatattgtc atttttaaaa 1280581 caaaaaaatg gggagctgga ctgcccccat tttgatatgt ggcgactagt aaccgtaacc 1280641 tcccccatat cctccgccat aacctccgcc gtaaccgtac caagggtagt aaggcggtcg 1280701 cgggcgcggg tagtaataag gcgggcgcgg ataaaacggg tagaacggat aatacggtct 1280761 tggataataa taaggcggat aaaatggcgg tctcggacgc ggataataat aaggctgtct 1280821 ttcatcataa ggggtaattt gttcaaatga ctgttcattc aaagggtaat ccaagaggaa 1280881 aacctcccta gcttttttta ttccttttac catattcctg atgcttaagt tgggtgtatg 1280941 tacattcatg aaattcggtt ttttttatga tgaaattcct taaaaaggat tgacatgaac 1281001 ttctaaatct catagtatta caaatgtgaa ataaatgtta ctacaatgtt acaaaaacat 1281061 ttctaaatag atacagttcc aactgatgaa gagtaaatcg aaatggctac gaaagaagga 1281121 gtttttgttg ttggcaaaaa gaatcaaatg gtttcatgta ttaatagcag ttgtatgtgt 1281181 ggtgggcctt atcggctttt tccataatca ttcattgaaa aaagaaacgg tcatgaataa 1281241 agtaagaact gattctcaat atgggaatgt tgagatcgca acgcttgtga atgacgggaa 1281301 aacttttaat tacgcggtaa actatcctgt tttcaaaaat gaaaaaatgg attcggcatt 1281361 aaaaagattc gcagaaaaag aggttcgtca atttcaaaag gaaacaaagg acgttgacca 1281421 agagcatacg acaaaacgca acgaattaaa tgttgattat aaaattgtcc attatgccaa 1281481 acagacagtg gcgattgtat ttaatgaata taaatacatc ggcggggcac acgggcaaac 1281541 cgtgaaaaaa acgtttaact atgattttag taaacaagcg tttctttcca ttgatgatat 1281601 tttcaaagag gacgctgact acttacataa gctttcgtta atcgcttatc acgagctgaa 1281661 aaagaataag gacattgccg cggacgatgc actgttaaag gaagggacgg ctccgaaaaa 1281721 agaaaatttc agccgctttg ccatcaagga ggattatatc gaactttact ttgacacata 1281781 tcaggttgca gcaggctatc ttggagagca atcgattgcc attaagaaaa gtcttttgaa 1281841 agacattctg aaagaacaat atattgataa agcaaaaaat aaaaataaaa tcaaagaaca 1281901 aaagccgaag catgaagtga tttctttacc caaagaggaa acagttgatc caaatcaaaa 1281961 agtcattgcg cttactttcg acgacggccc gaatcctgcg acaacaaatc agattctaga 1282021 ctccttgaag aaatataagg gtcatgccac gttttttgtt ttggggagca gagttcaata 1282081 ttatccggaa acgctaataa gaatgctgaa agaaggaaat gaggttggga accattcatg 1282141 gagccatccg cttctcacaa ggctttcagt gaaagaagcg ttaaagcaga tcaatgatac 1282201 gcaagacatc attgaaaaaa taagcggata tcgtccgacg cttgtaagac ccccatacgg 1282261 cggcattaat gatgaactgc ggagtcaaat gaaaatggat gttgcgttat gggatgttga 1282321 cccggaagat tggaaagacc gtaacaaaaa aacaattgtt gaccgtgtca tgaatcaggc 1282381 gggagatgga agaaccattt tgattcacga tatttaccgc acctctgctg atgcggccga 1282441 tgaaattata aaaaagctca ccgatcaagg ctatcaattg gtgacagttt ctcagcttga 1282501 agaggttaaa aaacaaagag aagcgaaata aattagaaaa ggctgtccgt acggacagcc 1282561 ttttttctat ttaataagag cctgtggtgg cccaaacatt taagtttggt cctgaatact 1282621 tgccgaaagc gtaagaagtc cttggatcta aatcatatac catcggtgta tagcaagact 1282681 tttggccggc caccgctttt ccattgccgc ctgcagaatc acaattatat ctttttccgt 1282741 ctgtgttccg ggtaatctcc gcatttgctt catagccaga cgtcaatgta ttattcatcg 1282801 tgatttttgc ccaagccgtt ttacatgtac tgctgaattt aagctcgact actccgatga 1282861 cttgattgct ggcattcact aagtttgagg atttttttgt agagccgctg gacgcacaat 1282921 cattgtaata agggcttttt ccatcgtagg catgggtttc cgccttggcg ggtgcacctt 1282981 tgacggcaaa aacaaatact actgcgaata acaccaatga agccttcata aacagtcttt 1283041 tcaatttatg acctccttaa tatggcaaac aataaatcat atggaggaac aatcaaaaca 1283101 tgcatgcttt tttgtgaaca ataaaggcgg ccgggaggat ggagttcttg gccgcctctg 1283161 gtatgaggtt atgcttttac atcaatggtt tgtccgagag ttggatgttg aatcatcttt 1283221 aaggtttgat cggcattttg ctgggcggtg tccagccttt ttttcgttaa agcaatattt 1283281 acattctggg caagggatgc ttgatgcatc gcaaccgata aagcaggaat atccatggtt 1283341 ccacctccta tgccttacct atcggcgggt ttgtatgatt ttacagtgaa aaatggctta 1283401 atttctcttg ttgaccctta cgctgcggca tatcgtatgt ttttgacaag gagggaatca 1283461 ggatgaatct agtaatggaa aagacctttg agcaatacga aaagctgttt tcaatggaag 1283521 aacagaaaag agaagatgta tttcggtata cgatgatgag gccgtttgaa aagatgtgga 1283581 ccgccatcca agttccgctg aaagcgaagg agccaaacgg ctatgatgtg atcatggctg 1283641 cgaaaatgct gggctatttg gatgtccgtg atgctgaaag cggccagaaa gcactacaaa 1283701 tactgaaaga atcacatgtt tcagagacag ctgaatctgc acttcggcaa tgcatatttt 1283761 ttgctgagcg cgaacagctg cgggtgaatg caaaggagat caaattcggc ctttatatcg 1283821 ctgatccaaa taagcttcag ctgcaaaaag gctactgcgg gtttggcggg ataccgggct 1283881 ttattcatgt atggattaat ccgaacagtt ataacctgcc aaggattcct tccattattg 1283941 ctcatgagtt tcatcataat gtgcggtttt cgtatataga ttttcatcat ggctctgtaa 1284001 gtgtcgggga ttatcttgtg attgaaggat tggcggaatc attcgccaga gagctgtttg 1284061 gtacggaacg attgggccct tgggtaactc gttttgatca tgaagacttg caatattcca 1284121 ttgatgtgat taatgaggtg ctggatgtga aaggattttc ggaagtcagc cgttatatgt 1284181 ttggtgatcc aattgctaac gaccaaggct ttaagcctgc aggtttatcg gcttttgcgg 1284241 gttatgcagt tggctatcat gccgttcagt catttatgaa tcaacatcat atcacgataa 1284301 gcgaggccac acgtttggat gcgaagacca ttatttctca atgcggtctg ttttctacat 1284361 gaaaaaagcg tcacatacag cggcgctttt tgattcccaa aaccagcagt tctatggcgg 1284421 cacaggcggc aattccgatt gtatatgctt cgatatcgct ccataaaaaa ccgtacccta 1284481 gtacaagccc gccaagagaa gtatctctaa tctggtcgat ccattcggca tgatagagct 1284541 ggctgaattc aatgacaaaa cagaaagaaa gactgataat gcccgttatc attgtcttca 1284601 gcttccgaaa tagaaatccg catcccgtga agatcatggc ggcccacaac gagtctccca 1284661 gataagtatt gagggtatca ggaagaacac tggagaatgc tctggatcca agccccagcc 1284721 caatgatcag tatggtgaaa actgcatata tccaacgatt tcgcttcatt gcgaattgat 1284781 accccgtctc tgcttcatct ccctgtattg taaggaatat agcttttatt tgtccactaa 1284841 aaaagcggct gaatagccgc gtagggtgtt tattttgctt ttaggtttac atggtcggct 1284901 gtctgatccg tgcctattac aaaatggagt tcatagcggc ctgtatcata tacataatcg 1284961 atttcatcgg taaacgggac ggttaacacc cgatttactg gtcctaattg cttctgcagc 1285021 acttccggcg taactccgcc taaattcagc tgccgttcca caccggttcc aaagtagcgg 1285081 atttctgaaa ttgtcatgtc tttatgatag gaaaatccgt agcccggctg tcccatattc 1285141 cagtgatata aatcaaatcg attgtctccc ccgactggtc tttccggttc cccaaacgca 1285201 gcgtggacat ccccttttgt gcttttgtta atggtaaggc cttgcgcctg ctgaggcatt 1285261 tcccctttat aggcggtgtt atagaggttt ttgacaagct cagcggctga ttgattcgtg 1285321 ttttctgaga gtgtgtttgt ttgagctgcg gcctttgccg gtgctgaaaa ggacgcagcc 1285381 ccaaagccgg taaaacagct tgttactgct gctgccgcgg ttatagcaga cattgtcttt 1285441 ttcatgttaa tccctcctaa ttgatctacc attccgtttc cccgtgtttt tgcaacgaaa 1285501 catgtgagtg cgctttgtat gttttattga gttgttgtaa gggaactgaa ataggtaatt 1285561 cggtatataa agcaagaaag gggaatggag atggctggca agaaaacaat cacaataaac 1285621 ggcgttgaaa tggaagcgtc cgaggaacag acggtgctgc agcttttgaa taacagctcg 1285681 attgaagtgc cgcaagtttg ctatcatcca agcttagggc cgattgagac atgtgatacg 1285741 tgcatcgtca gcatcaatgg tgagctgaag aggtcgtgct ccgctgaatt aaaggatggg 1285801 gatgtcattg atacgctctc acctgacgtg aaaaaagcgc aggtcatcgg gatggacaag 1285861 attttatata atcatgagct ttattgtaca gtttgcgatt acaacaatgg gggatgcgaa 1285921 atacataata cggtgaagga aatgaaaatc aatcaccaaa gcattccgtt tgatcacaag 1285981 ccataccata aggatgaatc ccatccgttt tatcggtatg atccagatca atgtatattg 1286041 tgcggacgct gtgttgaggc atgccaagac gttcaggtaa ctgaaacgct gaccattgac 1286101 tgggagcgga aacgcccgcg cgtcatttgg gataacgacg tgccgatcaa tgagtcgtca 1286161 tgtgtgtcat gcggccattg ttcaacggtc tgtccgtgca acgcgatgat ggaaaaagga 1286221 atggaagggg aagccggata tttaacaggc atcaataacg aaacgctgcg accgatgatc 1286281 gagatcacga aaggcgtaga gacaggctac ggctcgattc tcgcgatttc tgatatggaa 1286341 tcggccatgc gtgatgaacg aatcaaaaaa acgaaaaccg tctgcacgta ttgcggcgtc 1286401 ggctgcagct ttgatgtctg gacaaagggc agagacattc tgaaagtaga gccgcaggag 1286461 gaagcgcctg ccaacggcat ttctacttgt gtgaaaggca agttcggctg ggatttcgtt 1286521 aacagcgaag aacgcctgac aaagccgctg atccgtgaag gcgatcattt ccgtgaagca 1286581 gagtgggagg aggcgttatt gctgatcgcc agcaagttca ctgaattaaa agaggcgttt 1286641 ggcccggatt ctctcgcttt tattacatct tctaaatgta caaatgaaga atcctatctt 1286701 atgcaaaagc tggccagagg ggtcattggc acaaataatg tggacaactg ctctcgctat 1286761 tgccaatctc ctgcgactgc cggcctgttc cggacagtcg gctatggcgg tgattcagga 1286821 tcaattacag atatcgcgca agcggacctt gttttgatta tcggttcgaa cacgtctgag 1286881 tcgcatccag tcttatccac tcggattaaa cgggctcata agctgagagg gcagaaagtg 1286941 atcgtcgcgg atatcagaaa gcacgaaatg gcagagcgct cagatttatt tgtccagccg 1287001 cgtgccggat cggatatcgt ctggctgaat gcgatcgcca aatatttaat agaaaacggc 1287061 aaggccgatg aacgattttt gagagaaaga gtgaacggac gggatgaata tgtaaaaagc 1287121 ctcgcgccgt acacacttga atatgctgag gagaaaaccg ggattgatca agaaaccctt 1287181 atccaaatgg cagagatgat cgggcaagct gacagtgtgt gcgcattgtg ggcgatgggc 1287241 gtgacacagc atattggagg aagcgacacg agcacggcga tctctaatct gctgcttgtg 1287301 acaggaaact acggaaaacc gggagcaggt tcttacccat tgcgcggcca taacaacgtg 1287361 cagggagcaa gtgactttgg gagtatgcct gacagactac cgggctatga aaaagtgacg 1287421 gacgaacaag tccgccaaaa atacgagcgt gtgtggggtg tgccgctgcc gaaggagccg 1287481 ggtatgacca accacgaaat gattgaaaaa atccattccg gacagttgaa agcgatgtat 1287541 gtaaaaggtg aagaaatggg ccttgtcgac tccaatatca atcatgtaca cgctgcatat 1287601 gaaaagcttg atttctttgt ggtgcaggac attttccttt cacgtacagc ggagtttgct 1287661 gatgtggttc ttcctgcgag cccgagcctt gaaaaagaag gaacgtttac aaacacagaa 1287721 cgccggattc agcgtttgta tcaggtattt gaaccgctgg gtgaatcaaa gccggattgg 1287781 cagattatta tggaggttgc caataagctt ggcgccggct ggctctatga gcatcctgca 1287841 gacattatgg aggaagcagc caagctgtcg ccgatttatg ccggtgtcac ctatgaacgt 1287901 cttgagggct ataattccct gcaatggcct gtaaacgctg atggaaagga ttcgccttta 1287961 ctctttacag agcgcttccc tttcccagac ggcaaggcca ttctctaccc tgtccagtgg 1288021 acagagccta aggaattcgg tgaggaatat gatatccatg tcaacaatgg gcggctcttg 1288081 gagcacttcc acgaagggaa cctgacttac aaatcaaaag ggatttcgga gaaaacaccg 1288141 gaagtgttct tagaaatttc tcctgagctt gcggcagaac gagggattca ggacggaacc 1288201 ctcgtcagac tcacatcgcc tttcggaaat gtcaaagtga agtgcctgat tactgatcga 1288261 gtcaaaggga aggaagtata tctgccaatg aacgattcag gggaagcggc gatcaacctg 1288321 ttaacaggca gccatgccga taaggatacc gatacgcctg cttacaaaga aacatcggcc 1288381 aagatggaaa ttttgaagca cgacggaatc agcccgctgc ctaagatcaa ccaccgcaac 1288441 ggcaatccgc agccgcaaat cggtgtgcag gttcataaga aatgggcgcg gaaggattat 1288501 attttccctg gtgacgctgt gaaaaggggg atgggccata atggctaaag cgattaaacg 1288561 aatccaaaaa atcgaggtaa cagaagagga tcagcgaaag cgtgatttgc gggaaattga 1288621 agatgctcta attgaccaca aagaagcgat tctcgaaaca ttgcatatgc tgggccatat 1288681 gaacgagcgc ggggtcctgc cgttgctccg cggccttttt ggtcaagggg ataaagttct 1288741 tgatatcctg gtgaaaaagg cagatacaga ggaaacagcc aatacgctga aaaatctgct 1288801 tcttctgttt ggaacactcg gcatgctgga cgtgaagcag ctggagcctc tcattttgaa 1288861 agtgaatgcg ggtgtggcaa gcgctgtaga gcagaaaaac agtgaagaaa agacaggtta 1288921 ttttgatatt atccgctcgc taaaagaccc ggaaatcaac aaatcaatta cactgctctt 1288981 ttccttttta aaaggaatgg gacaagatac aaaggagctg gaacgcacga cgcagcctcc 1289041 ggaacaccaa aaacatcatc aggaaccccg agagaaaaga ggaatgaata agcgagattg 1289101 acctcccacc cgagcggctt cagccagctc gggttttttg atgaaaaggt ctaatggact 1289161 agtaaaaaat attcaaatac taggaagaag taagattgtg atgaatgaga tagaaataat 1289221 cgttactttc ttacctgtta agaaaaggga aaatctgatt ataatagaaa tcgattactt 1289281 tagatggggg aacaatcatg aaaaaagtct tattactatt atttgtcttg acgatcgggt 1289341 tagcgctttc tgcgtgcagc caatcgagcg atgcgtcaga gaaggaaaaa ccgaaagaga 1289401 aaaaatcgca agaagagctt gaaaaggaac ttgataagga attgaaaaaa ggcggtgagc 1289461 cgaagaccaa aaaagatgat caaatacata aaataggaga aacatttaaa gcaggacata 1289521 cgaattttac agtgaataaa gttgatagag tgcaaaaagg tgaatatatg aatgttggcg 1289581 gagctgtaaa tgaggagaca aaaacaataa aagatgatga ggaacggctt attatagaag 1289641 ttacgatgga aaatataggg gaagattcaa taagctacaa ttttatcggg tttgatttaa 1289701 gagataagaa tgatcaatca gtgcggcctg ttttttctat agaagagaag ggcagaatcc 1289761 ttatgggagg aacactagta tcggggaaaa aggttacagg tgtactcagt tatgtcatcc 1289821 ctaaaggaga acagaaacat tacacactgg tatataatcc gtttttagct gatacaaata 1289881 gcagtaatac agaagagaga gtaaaggacg atattgatta cttggtgaag ttagattaga 1289941 tgctaattta cagttgcacg tttttcatct gtggaaaacg tgcatttttt atagcgaaac 1290001 ttgacttgaa aggatgagtg ataaaagtgc aaaccaaatg gctggaacgg gcacagcgga 1290061 ttcgggcgat cgcccaagcg gggcttgctt tttccaagga tgtgtacgac agggagaggt 1290121 acgaagagct aatgaagctt agcgcggaaa tgatggcgga ttactcggag aaggacattg 1290181 aagttatcac tgatttatgg caaggcgaga agggctatcc aacaccgaaa gcggatgttc 1290241 gcggcgctgt attcagagag aatcagattt tgcttgtccg ggagaagcat gatgagctgt 1290301 ggtcgctgcc gggcggattt tgcgagattg gtttatcgcc ggctgaaaac gttgtcaagg 1290361 aaatcaaaga agagtcgggg tacgatacag agccgtctcg attgctggcc gtgctagaca 1290421 gccataaaca ctctcatccc cctcagcctt atcactatta taaaatcttc atcgcatgca 1290481 gcatgacgga cgggcagggg gaaacaggga tcgagacgaa tcatgccgct ttttttccgg 1290541 aagacagact cccgccgctt tctcctaaac gaaacacacc ctcacagctt agcatgctgt 1290601 ttgacttttt gcgccatccg gacaagaaaa cgatatttga ctaaaaaaga aagagcctgt 1290661 gggctctttc ttttttataa tgtaatgtgt ttttcgttgg cgagtttcag aagggtcaaa 1290721 atagaatcgg cttgtttatg gccgagtttt tgctttaatt tgttttcttc aactaatcgg 1290781 ctgccataaa ttttgacgga ggctttgtcg acgacagtat gccagttttc ctgttttttt 1290841 ccctcaacaa gcggtttttc atgtctctca gaaaaagaga acacaaagag tacgaatgca 1290901 agtgaaagta ggattccgac aacttgtttt ttgtaatcag tctgtgctgc cacgttgttc 1290961 tctccttcac cttttacctt ctatttaatc atagaaccaa attattttac ataatgggaa 1291021 agtcattttt ggagttagtg catttggttg aaaacagaga cgttttttga gcggagcggt 1291081 gcaattgaat ccatattgga tttgcgtgct tatgcctaag gtcacgttgt gagccaaaac 1291141 agcagtgcag aatagaaaaa aattgaaaga ttatggtaag atgaacgaaa ttcgaggggg 1291201 aatatatgat gcctgcatcg aacatcgtga tcgcctgcct gctgttatca atttaattat 1291261 ttgtggtagt ccctctcttt ttcgaaagcg ggaggtgaag tggaacatta attgctgaat 1291321 tctttcaagg ggagtgaccg tacatgaatg tgttaaaccg ccggcaagcc ttgcagcgag 1291381 cgctgctcaa tgggaaaaac aaacaggatg cgtatcatcc gtttccatgg tatgaatcga 1291441 tgagaaagga tgcgcctgtt tcctttgatg aagaaaacca agtgtggagc gtttttcttt 1291501 atgatgatgt caaaaaagtt gttggggata aagagttgtt ttccagttgc atgccgcagc 1291561 agacaagctc tattggaaat tccatcatta acatggaccc gccgaagcat acaaaaatcc 1291621 gttcagtcgt gaacaaagcc tttactccgc gcgtgatgaa gcaatgggaa ccgagaattc 1291681 aagaaatcac agatgaactg attcaaaaat ttcaggggcg cagtgagttt gaccttgttc 1291741 acgatttttc atacccgctt ccggttattg tgatatctga gctgctggga gtgccttcag 1291801 cgcatatgga acagtttaaa gcatggtctg atcttctggt cagtacaccg aaggataaaa 1291861 gtgaagaagc tgaaaaagcc tttttggaag aacgagataa gtgtgaggaa gaactggccg 1291921 cgttttttgc cggcatcata gaagaaaagc gaaacaaacc ggaacaggat attatttcta 1291981 ttttagtgga agcggaagaa acaggcgaga agctgtccgg tgaagagctg attccgtttt 1292041 gcacgctgct gctggtggcc ggaaatgaaa ccactacaaa cctgatttca aatgcgatgt 1292101 acagcatatt agaaacgcca ggcgtttacg aggaactgcg cagccatcct gaactgatgc 1292161 ctcaggcagt ggaggaagcc ttgcgtttca gagcgccggc cccggttttg aggcgcattg 1292221 ccaagcggga tacggagatc ggggggcacc tgattaaaga aggtgatatg gttttggcgt 1292281 ttgtggcatc ggcaaatcgt gatgaagcaa agtttgacag accgcacatg tttgatatcc 1292341 gccgccatcc caatccgcat attgcgtttg gccacggcat ccatttttgc cttggggccc 1292401 cgcttgcccg tcttgaagca aatatcgcgt taacgtcttt gatttctgct tttcctcata 1292461 tggagtgcgt cagtatcact ccgattgaaa acagtgtgat atacggatta aagagcttcc 1292521 gtgtgaaaat gtaatagata aggagactgg agattcatga aaaagtacca tatttcgatg 1292581 atcaatatcc cggcgtacgg acatgtcaat cctacgcttg ctttagtaga gaagctttgt 1292641 gagaaagggc accgtgtcac gtacgcgacg actgaggagt ttgcgcccgc tgttcagcaa 1292701 gccggtggag aagcattgat ctatcataca tccttgaata ttgatcctaa gcaaatcagg 1292761 gagatgatgg aaaagaatga cgcgcccctc agccttttga aagaatcact cagcattctg 1292821 ccgcagcttg aggagttata taaggatgat cagcctgatc tgatcatcta tgactttgtt 1292881 gcgctggctg gtaaattgtt tgctgaaaag cttaatgttc cggtcattaa gctctgttcg 1292941 tcatatgccc aaaatgaatc ctttcagtta ggaaatgaag acatgctgaa aaaaataaga 1293001 gaagcagagg ctgaatttaa agcctacttg gagcaagaga agttgccggc tgtttcattt 1293061 gaacagttag ctgtgccgga agcattaaat attgtcttta tgccgaagtc ttttcagatt 1293121 cagcatgaga cgttcgatga ccgtttctgt tttgtcggcc cctctctcgg agaacggaag 1293181 gaaaaagaaa gcctgttgat tgacaaggat gatcgcccgc ttatgctgat ttctttgggt 1293241 acggcgttta acgcatggcc ggaattttac aagatgtgca tcaaggcatt tcgggattct 1293301 tcatggcaag tgatcatgtc ggttgggaaa acgattgatc cagaaagctt ggaggatatt 1293361 cctgctaact ttaccattcg ccaaagtgtg ccgcagcttg aggtgttaga gaaagctgat 1293421 ttgttcatct ctcatggcgg gatgaacagt acgatggaag cgatgaacgc aggtgtgccg 1293481 cttgtcgtca ttccgcaaat gtatgagcag gagctcactg caaatcgggt tgatgaatta 1293541 ggccttggcg tttatttgcc gaaagaggaa gtgactgttt ccagcctgca ggaagcggtt 1293601 caggctgtat ccagtgatca agagctgctc agccgcgtca agaatatgca aaaggatgta 1293661 aaagaagctg gcggagcgga gcgtgcggca gctgagattg aagcgtttat gaaaaaatcc 1293721 gctgtcccgc agtaaaaaca taaaaaccga aatcaatttg atttcggttt tctgtttaaa 1293781 tatttttttt catcccgcat ctccggcatt ctctaagaaa ttttccgcct tttacagagc 1293841 ttttgaacag tgtgtaatca cagttgtcgc agcgcccgct gcgggcatcc ggatattcat 1293901 tgaattcgta aacaatcgat gtatcgtagc cttttgtttc atattcttct tttttggttt 1293961 ccatgtcgat cctccgttac aagacgtgtc tgctgtttat cttacagcaa gcttccggcg 1294021 tattcaatgg attttaggag gttgggttta tcttgatttc tcccttggtt tgcgccaaaa 1294081 tagctttatt aagcttatat acataaaaag cctatgcaaa gaggagagga aacgggtatg 1294141 ggaaaagggt tacttggaaa acgcgtggca atcggtggct cacgaaaaac ggaagaaatt 1294201 agtacaatca ttgaaaaaca gggcggaata cctgtcatcc ggcctctcca aggtacagtt 1294261 tacttagcag agaagcaggt ggagccggat ttgcggacgt ttgcggaaga aaaagctgac 1294321 tgggtcattt tcacgacagg catcgggttg gagactcttg tcgatatggc agagaaaatt 1294381 ggactgaaag atgagtttct gcaggccatt cgccaagcga aagcggcatg ccggggatac 1294441 aaaacgctgt ctgcgctgaa aaagcttgga atcacaccgg aagcttcgga tgaagacggg 1294501 acaacaagag gcttaatccg ttccttggag cctcacgact tttcaggaaa aacagtcatg 1294561 gtgcagcttc atggcgaaaa agcgccggct ctcatggcat ttcttgaaga aaaaggcgcg 1294621 tctgtcctgc cgattctgcc ttatcagcac atcccgccgg aggaggaaac ggtggagcgg 1294681 ttatgccgag agctgatgaa cgatgaggtc gatgccgttt gttttacaac ggccattcag 1294741 gttcgttccc tgtttgattt tgccaagggg cgaggttata tcaatgaagt gaagaaggta 1294801 ttcgaagaac gcgccatcgc agctgctgtc ggaaaagtga ctgctgaagc actgcgggaa 1294861 gagggcatta cgagactgct tgcgccagag attgagcgga tgggtgcgat gattgttgag 1294921 ctggccaagt attatgaaga aaaggaataa caagtacaaa aagccgcttt tccctcggaa 1294981 agcggctttt gtctgtcatt cattttgctt cagctgctga tgaacggtga ataatgatgg 1295041 gtatgtcagc acgcttaaga ttacacaagt cagcgcggct gaggccatcg ttgtaaacac 1295101 gattaagagt tgaaagcgta ctgcctgaat cgggtccgcg ccggctagaa tctggccagt 1295161 catcatgccg ggaagctgga caagacccag tgttttctgg ctttcgagcg tcgggatcat 1295221 actcattttc atcgctgagg taagaatgcg ctgtatggat tgcttcggtg tgccgccaag 1295281 tgacaatatt aattgaattt cttctttgcg aacgccgact tctgagttaa gccggtttag 1295341 aaacaaactt gagagcacca tcgaatttcc gatgaccatc ccgctgatcg gaatgacata 1295401 tcgtgccgta agcggaatga tatgaagaga cagcagaatt ccctgcgtca caatttctac 1295461 gattgctaac gcggcaaaca ccctccaaaa cgaaccgata gtatttttct ttcgcttgat 1295521 gacattttgc gccgccaccg cgagcattaa cagcaccatc agcaggataa aaacagggtg 1295581 gtctccgcga aaaatcagcg acaaaacata accgatgata agcagctgca ccgcggcccg 1295641 gatggtggcg atgatcatgt ctttttctac accggcttta aaggattttg ataaaaacaa 1295701 ggcgatcaaa acaaagatca tcgttaaaga gagagaaagg taatccatta ccgagtgcct 1295761 cccttcaaaa attctttcgc tgcttcatgc tgcggagcgg agaaaaatgt gtcggtttca 1295821 gcgatttcaa gcagccggcc atctgccata aaccaaatgg tatcggctat tcgttttgcc 1295881 tgctccatat tatgagtgac ccacatgact gtccattttt tctcttgatg ctgacgtttg 1295941 atcagttctt caatctcaag agcagagacc gggtccaagg ccgatgtgat ttcgtccaac 1296001 aatagaatgg aggaaggatt tgagagcgtt ctggccagtg acagtctttg ccgctgcccg 1296061 cccgataagt ctctggcgct tctgtctaac aactctggcg gcagccctgc aagcgaagcc 1296121 agcttttcag gagagtacag ctgggattga tgcagccttt gtacaagact taaattgtca 1296181 cgcactgtcc cgtcgagcac gggagccgat tgaaacgcga gggctgccgt tcgcctcagc 1296241 tcattgacat tccattctct gacttccttt ccgtatatgt tgacttcgcc gctgtcaggc 1296301 gttctcatta aattacacat agaaaggagg gtgcttttgc ctgagccgga agggcctaaa 1296361 acggctacga ttgcaccctg ttgaatgtct ccggtgacat cctgcagcac atcataggtt 1296421 tgtccatctt gtttatagct ttttctgact gatctgaagg agatggctgg tatgttttgt 1296481 gtttgatcgt ttgcttccat tacaataatc acctttcaat ataagtaggc tgacattata 1296541 tttaactata acgtgaaaca gattcctttt ggtagcacaa ataaaggaga acaggctttc 1296601 acccattctc ctgcagatgc tacgcagtca gatttgactg tgctttcttt ttcggttttc 1296661 tcggctgtga agcgaaggta tgtaacatca tccccgctat tataatgaac aaaccggcaa 1296721 atgataatag agatgggaaa acgcctgaca gcagaacaat ttcaccaagc agcgcgaaaa 1296781 tcacttcacc ggattgagtg gcttcaacag ctgcgagttt ttgcggattg tctcttacca 1296841 tatcagtggc ccagaaaaat aaaaccgtcg caatgatgcc tgagctgacg gcaacgataa 1296901 aggattgaac ggtttgactt gctgttggaa ggccatctga ccaccagccg taagctgcta 1296961 atataagcca gaatggaagg cttgccaatg tcattccaag cacgcgctga aatgtatcaa 1297021 gccggcctcc gtattcttcg agcattcttc ggtttcctaa cggataggca aaagccgcaa 1297081 tgacaaccgg cagcacactg aaaagcagca tcctcccaga aagcgattct gcatgctgaa 1297141 gctgaatcag agccgctcca atcaggatga tcacagaagt gccaagtgaa accaggggaa 1297201 tcttttggcg aatgagctgc ggaccgcccg gcatatcttg tttgacataa aacaaaggag 1297261 ataagagcac cccggctaca attgtaattt gccaggttcc agctatgagc caccccggac 1297321 cgtatgcagc cgcaaatgta atcggtgcgt aaaaaagcac gaaaccgacg aagctccatt 1297381 tgatccaata aaacggcttt ttcctcattt ctagtaagag aggcgtgaat gtccctctca 1297441 tgatgacaat caaacataaa aatggcacca taaaaataaa gcgcagcgaa gagctccaaa 1297501 gccagctgcc tcctgataac tccatcgctc tgtttaatat aaaggtaacg gcgaaaaaga 1297561 gtgaagccaa tattccgata acgatagctt tcatgatatc cctcattctg gcattatttt 1297621 tttatactat actattcggt atcatgcaga tcaatggaat catgagaaaa acatcatgtt 1297681 tggcgaaccg ctatatgtgg aagacaaaaa agggaggtga aattgatgga aagagagaca 1297741 cagacatact tctttccgga tgacggcagg attccgaatc accctgattt tccgctcgtg 1297801 gtgtatcaaa acgcgcttaa ggacaccgga ctggcagagc ggatcgtcac ccggcatggc 1297861 tggtcaaaca gctggtcagg gagtgttttt ccataccatc attatcacag caatacgcat 1297921 gaagtcctga ttgcccttag gagagaggct gtgattcagt ttgggggaga aaaaggggct 1297981 gccatccctt tcaaatcagg cgacgcagtc gtgattccag ccggagtcgg acataaaaag 1298041 ctcagctcaa gccccgattt tactgtcctt ggcgcctatc ccggtggcgt tcagtacgat 1298101 atgaagacgg ggaagccgaa tgagcgggag gaagcggtca aacagattaa gcaggcggcg 1298161 ttgccggcga atgatccgat cacaggaaaa agagagcctc tattggaaat atgggtaaag 1298221 tgaaggggag aaattgctgg attgtcaata actagtgccg cagaaacgat atgacatgag 1298281 ctccatataa attaatttca taatcgaagc aattcacgtt caaattttgt tcaaaaagtg 1298341 ttatcatata gaaggtaatc gaattggagt tttttgtgtt tgctattttc agagagagta 1298401 aaggattttg acttattcaa ttgtttattt ttagataaaa ataatactga atatggcaag 1298461 atgaaaaact gggtagtaaa catttatttt tgtaaatgat tgtgcatgaa ttcacaatcc 1298521 ttattcttat gccttaaaag cgtgagacag ggagaggcac taccctttcc aaaaaaatca 1298581 gcaaactgct tatagtaaag gagaattgga tatgccagaa acaatcgatc aaacaaatgc 1298641 gtctgtcagc caaagccagc aagatcttat tgatcagcta ttaaagccag aagttcaaga 1298701 atcattgact gttttagttg accagcttcc gaagctgact gagttagtga atattttaac 1298761 gaagtcttat gatttcgctc agtctgtagc gactgacgaa gtgttaaaga gcgacacagt 1298821 cggtgcgatc actgaaattc tcgagcctgt aaaagaaaca gcgaaagaag tagctgcgac 1298881 tgcgatcgaa gcaaaagacc gcgcggaagc aagcaacgaa acaattggac ttttcggcct 1298941 tcttcgcatg ctgaaagatc ctcaagctca aaagctgttc cgttttgcta acagctacct 1299001 tgaagtcatg aacgaacgcg aaaaccaaaa ataatctcag attcaaattg atataaagga 1299061 cggaggatat acgatgtcaa aacatattgt cattctaggc gctggttatg gcggagttct 1299121 ttctgctcta acagttcgca aacattacac aaaagaacaa gcacgcgtga cagtggtaaa 1299181 caaataccca actcaccaaa tcattacgga attacaccgc cttgctgcag gcaacgtgtc 1299241 tgaaaaagcg gttgcaatgc cattagaaaa acttttcaaa ggcaaagaca ttgatcttaa 1299301 aattgcggaa gtaagctctt tctctgttga taaaaaagaa gttgcgcttg ctgacggttc 1299361 tacattaact tacgatgcgc ttgttgtagg tcttggttct gtaacggctt acttcggcat 1299421 cccaggtctt gaagaaaaca gcatggtatt gaaatctgct gccgatgcga acaaagtctt 1299481 ccaacatgtt gaagatcgtg tgcgcgagta ctctaaaacg aaaaacgaag cagatgcaac 1299541 aatccttatc ggcggaggcg gcttaacagg tgttgagctt gttggtgagc ttgctgacat 1299601 catgccgaac cttgcgaaaa aatacggcgt agaccataaa gaaatcaaat tgaaacttgt 1299661 tgaagcaggt ccgaagatcc ttcctgttct tccggatgat cttatcgagc gtgcgactgc 1299721 aagccttgaa aaacgcggcg ttgagttctt aacaggtctt cctgttacaa atgtagaagg 1299781 aaacgtaatc gatctgaaag acggatctaa agttgttgcc aacacatttg tttggactgg 1299841 cggcgtacaa ggtaacccat tagtcggtga atcaggccta gaagtgaacc gcggacgcgc 1299901 gactgtaaat gacttcctgc aatctacatc tcatgaagat gtattcgttg ctggagacag 1299961 cgcagtttac ttcggtccag acggccgtcc atacccgcca actgcacaaa tcgcatggca 1300021 aatgggtgag ctgatcggtt acaacctatt cgcttaccta gaaggcaaaa cgcttgaaac 1300081 attcaagcca gtaaactctg gtacacttgc aagccttgga cgcaaagacg cggttgccat 1300141 cattggtgct aattctacac cgcttaaagg tcttcctgct tccttgatga aagaagcaag 1300201 taatgtacga tatttgacac atattaaagg acttttcagc ctggcttact aatcctttta 1300261 atgaatctgg cattgccaaa agcattcctt tccgagtgct ttctggcaat gtcttttttt 1300321 atgtttatga cagcgttaac atttcatttt caaaaaagag attgatccca aaggaatata 1300381 aaggtaaaat aaaaacaaat caaaatgtta acgttaacat tttgaaatag aatgaaagac 1300441 ggtgaggaca tggaaccctt catgggcaaa aactttttat tgaaaaatga aaccgctgtc 1300501 agcctctatc acaattatgc gaaagacatg ccaattattg attaccactg ccacttaagt 1300561 ccgaaagaaa tctatgaaaa taagacattt caaaacatca cggaagcctg gctgtatggt 1300621 gaccattata aatggcgcat catgagagcc aatggaattg aggagacata cattaccgga 1300681 gatgcgcctg atgaggagaa atttatggct tgggcgaaaa ccgtgccgat ggcgattggc 1300741 aacccgctct acaactggac tcacttagaa ttgcagcgtt tttttggcat ttacgagatt 1300801 ttaaacgaga agtccgggtc ggctatatgg aaacagacaa ataaactgct caaaggggaa 1300861 ggcttcgggg caagggattt aatcgtgaaa tcaaatgtaa aggtcgtgtg caccacagat 1300921 gaccctgttg attctcttga ataccattta ttgttaaaag aagacaaaga ctttcctgtc 1300981 agtgtgctgc ctggatttcg gccggataaa ggacttgaga tcaatcgtga aggctttcct 1301041 gagtgggtgc aggcgcttga agatgccgct gccatatcga ttacaaccta tgatgagttt 1301101 ttaaaggcgt tggaaaaacg agtgcgattc ttccactcag ccggcggcag agtttctgat 1301161 cacgcgatag atacaatggt atttgccgaa acaacaaaag aagaagctgg acggattttt 1301221 tctgacagat tacaaggaac agaggtttct tgtgaagatg agaagaaatt taagacatat 1301281 acgcttcagt ttctttgcgg tttgtatgcg gagctcgatt gggcgatgca gtttcatatc 1301341 aacgctttaa gaaacacgaa tacaaaaatg atgaaaaggc tcggacctga tacagggtat 1301401 gattcaatga acgatgaaga aattgctaag cctttataca agctgctgaa ctcagttgag 1301461 atgaagaacc agctgccgaa aacgatttta tattcactga atccaaatga taactatgtc 1301521 atcgccagca tgatcaacag ttttcaggac ggtattaccc cgggaaaaat acaattcggc 1301581 acagcctggt ggtttaacga tactaaagac ggaatgctcg accaaatgaa agcgttatca 1301641 aatgttggcc ttttcagccg ttttatcggc atgctcaccg attccagaag ctttctttcg 1301701 tatacgcgcc acgaatattt caggcggatc gtctgcaatt tgattggaga atgggtggaa 1301761 aacggcgaag tgccgcgcga tatggagctt ctgggaagca tcgttcaggg gatttgctat 1301821 gacaatgcga aacactactt tcaatttcaa gaagagaaag caaacgtgta acaaagtgtc 1301881 cgctcagtat cgctgagcgg atcactatcc gaaaattctt aagacacaga ggtggaacat 1301941 gcgaactgaa ctggcaaata aggttgtgtc ggtcgaaacg gaaaaaaggc tttcattgaa 1302001 agagaaaatg tcctatggct ttggtgattt tggcaacggt tttatgtttg atctcggcca 1302061 gatttattta ttgaagtatt tcactgatgt agcgggaatc cccgctgcga tggccggcgg 1302121 cattttttta gtcagtaagc tgtttgcagc gataacagat ccaattgtcg gctcatcaat 1302181 cgattatcgc aaaaacatcg gcaaacgggg gaaattcagg ccttatctat taatcggcag 1302241 catcgtgctt gcggtgctta ctgttcttat ttttctgtct cccaatgtat caacgaccgg 1302301 aaaactgata tatgcatatg catcctatat gatttggggc atcggctatt cgtttgtgaa 1302361 tattccgtac ggctcattag gggcagcgat gactcaaaat tctgaggacc ggacctccat 1302421 ttcgacgttc cgccaaatcg gatcacttgg cgccttgttt atcacaagtg tggccgtgat 1302481 gccgctgctc gtcaagtttg ataatccgaa ggtcggctac ccggtggtca tgggcttgtt 1302541 cgccgcgctc ggtgtgtttt ggttttatat ttgctaccgc aactgcaaag agcgcattat 1302601 catatcggaa gcacccaaag aaaaattaac actctcatct gtcgtcaaaa catttattac 1302661 aaataaaccg ctgttaaccc ttgtcctgat gacgattttt tcaatttccg catacaacat 1302721 taaatccgcc atgctcgtct atttcgcaca atataacttg ggcaatgttg aattaatggc 1302781 ttatatgaac ttcatcatta ttggttcttc ctttttgggc gtcgtattcc ttccaaagct 1302841 cgtcaagatg tttggaaaga aacgaacggc aatgatcggc tttggcatca gtgtggccgc 1302901 ggatctgatc aactttatgc ttccatctaa cgtttatgtg tttacaattc tcgccagtat 1302961 cgcctttatc ggaatcagta tcccaaatgg catcacgtgg gctcttgtct ccgatattat 1303021 cgactatggc gaatggaaat ccggtgaacg gaaggaagca acgacatatt cacttttcaa 1303081 tttctcaaga aagcttgctc aatctttgtc tggctttctc tcggggatcg gtttggggat 1303141 tatcggctat gtgccgaatg cagtccagac agcacaggcg ctgattggca tcaaagcgct 1303201 gcttcttctg tatccggcca ttgctttggc attagcgatg ttcattatcg gctttcttta 1303261 taaactcaca gaccagcagc atgctcagat cgttcaggat cttcatcaaa agagctgaca 1303321 atataatata aagaatattt aaaataattt gtaaataaaa tgtgtttgta ggggtttcgc 1303381 ttggagagtg cccaaaaaac tgaaaaggaa ggaggcactt gcttgaaaac gataacaatt 1303441 gcagctgaag aagcaaagga actcgtttgg caaaagctgg acggtgccgg tttgaatgaa 1303501 cgagatgctg aaaaagtggc agatgttctc gtgcacgctg atttgcgcaa tgtacattcg 1303561 catggcgtgc tgcacacaga acactatgtg aacaggcttt tagcgggagg gatcaatcct 1303621 ggggcacagc ctgtttttaa agagacgggg cctgtgaccg gggtgcttga cggagacgat 1303681 ggtttcggtc atgtgaattg cgacatggcg atggaccatg caattgacat ggcgaagaaa 1303741 aaaggagtcg gcatggtcac ggccgtaaac agcagccatt gcggagcgct aagctatttt 1303801 gtgcaaaaag cggctgacga aaagctgatc ggaatggcaa tgacgcatac agacagtatc 1303861 gttgtcccat ttggggggag gactcctatt ttagggacaa atccgattgc ttacggagtt 1303921 ccggctaagc ataaaaaacc gtttatccta gatatggcga catccaaagt ggcttttggg 1303981 aagattctgc aggcccgtga agagggcaaa gaaattcctg aaggatgggg agtcgatgaa 1304041 aacggagaag cagtaactga tcctgacaag gtcgtctcac tttcaacatt cgggggcccg 1304101 aaaggctatg gactatcgat tgtagtggat gtgttttccg gattgctggc gggcgcggct 1304161 tttggccctc atattgccaa aatgtacaac ggccttgatc aaaaaagaaa gctggggcat 1304221 tacgtttgcg cgatcaatcc atcctttttt actgactggg atacgttttt agagcagatg 1304281 gatgccatga ttgatgaact gcagcaatca ccgccggctg ttggattcga aagagtgtat 1304341 gtgcccggcg agatcgagca gctgcatgaa gaaagaaata agaaaaacgg aatttctatc 1304401 gcccggagcg tgtatgaatt cttaaaaagc aggtgagtaa aatgaaagcg gttcaagtgc 1304461 gaaaagcgta tgatctggtg acagcggagg tgaagaagcc agttctttca aaggatgatg 1304521 aagtgctcgt gaaagtcaag cgagtcggca tttgcggttc agacatgcac atttatcatg 1304581 gaacgaatcc gctcgctacc ctcccgagag tcatcggaca cgaggtaacg ggacaagtgg 1304641 aggcagttgg tgcgaatgta cagagcctaa aacccggtga tcatgtggtg attgagccga 1304701 tttcttattg cggatcgtgc tatgcctgcc gcaaagggcg gccgaatgtt tgcgccaagc 1304761 tttctgtatt tggcgtacat gaggacggag gcatgcggga atatattgtg cttccggaaa 1304821 gacagcttca cgcggtctca aaggacttgc cttgggagga agcagtcatg gccgagcctt 1304881 atacgatagg cgcccaggca gtgtggagag gccaggtgga aaaaggtgat accgtcctga 1304941 tccagggagc ggggcccatc gggatctgtg tgttaaaaat ggcaaaactg gcgggcgctg 1305001 ctgtcatgat gactgacttg aacaacgagc ggctggcatt tgcgaaagaa aacggcgccg 1305061 atgctgttgt aaatgtccaa gcagaacatg ttgccgagcg ggtccttgaa tggactggga 1305121 atgaaggagc aaacgtggtc attgatgctg tttgcctgcc ggagactttt gcactttcaa 1305181 ttgaggctgt gtcaccggcg ggacatgtgg ttgtgcttgg atttgatgaa agagcggctc 1305241 agatttctca gctgccaatt acaaaaaaag aagtcacgat aaccggatcc cgattgcaga 1305301 ccaatcagtt tccaaaagtg gtagagcttt tgaatggagg ccggttaatg cataacgggc 1305361 tggtgaccca tacattttca gttgatgacg ttcatcatgc atttcagttt attaaggagc 1305421 atccagatca ggtgcggaaa gccgtcatca cgtttgatta aatgactgaa tccggaggtg 1305481 cgagcatgaa tatgacattc cgatggtatg gacgaggcaa cgatacagtc acacttgaat 1305541 acgtgaagca aattcccggt gtcaaaggca tcgtttgggc tctccatcaa aagcccgtcg 1305601 gcgacgtgtg ggaaaaagaa gaaatcagag ccgaaactga atatattcaa tcctatggtt 1305661 ttcatgctga agttgtagaa agcgtgaatg ttcacgaagc gattaaactt gggaacgaag 1305721 aacgcggccg gtatattgaa aactacaagc aaacgatccg caaccttgcc ggatttggcg 1305781 tgaaagtgat ctgctataat tttatgccgg tttttgattg gacacgcacg gacatgttcc 1305841 ggccgctaga agatggatcg accgctctgt tttttgaaaa ggccaaggtg gaaagccttg 1305901 atcctcaaga gctgattcgg acggtggagg aagcatccga catgacactg ccggggtggg 1305961 agcccgaaaa attggctcgg atcaaagagc tttttgctgc ctacagaacg gtcgatgaag 1306021 aaaagctatg ggacaattta tcattctttt tgcaggaaat tcttcctgtt gctgaggcct 1306081 atggtgttca aatggccatt catccggatg acccgccgtg gccgattttc ggactgccgc 1306141 gcattatcac aggagaggca agctataaga aactgcgggc gatatcagat tcaccgtcta 1306201 attgtatcac cctttgtaca ggttcaatgg gagccaatcc cgctaacgac atggtggaga 1306261 tcgctaaaac gtatgccggc atcgctccat tttcacatat tcgcaatgtg aaaatttatg 1306321 agaatggcga ttttattgaa acatctcatt taacaaagga tggttcgatc aacattcaag 1306381 gcgtgatgga agaactgcat aagcaggatt acgaaggata tgtcagaccg gatcatgggc 1306441 gccatctttg gggcgagcaa tgccgcccgg gatatggctt atacgatcgg gcacttggca 1306501 tcatgtattt gaacgggctg tgggacgctt atgaagcaat ggcaaaaaaa gaggtgggca 1306561 tatgatcccg ctgcatgaga acctggctgg taaaacggct gtcatcactg gcggcagcgg 1306621 cgtgctttgc tctgcgatgg cccgggagct agcccgtcat ggcatgaagg tggcgatttt 1306681 gaatcggacg gctgaaaaag gccaagcggt cgtgaaggag ataacggcgg ctggcggcac 1306741 agcgtgcgct gttgctgcgg atgtgctgga caggatgtca ctggagcggg caaaggaaga 1306801 catccttggc caatttggcg ctgttgatct gttaattaac ggggctggcg gcaatcatcc 1306861 tgacgcgata accgatgtgg agacatatga agaagcggga gaaggccaat ccttttttga 1306921 tatggatgag aggggctttc taactgtatt ctccaccaac ttcaccggtg cgtttctggc 1306981 ctcgcaagtg tttggtaaag aactgctgaa ggcggattca cccgcgatca tcaacctttc 1307041 ttccatgagt gcttattcac ctatgacgaa ggttccggca tacagtgctg cgaaagcatc 1307101 catcaataat tttacgatgt ggatggctgt tcattttgcc gaaaccgggc tgcgggtcaa 1307161 tgcgattgcc ccaggcttct ttctgacaaa acaaaatcat gatctgctga tcaaccaaga 1307221 cggaacgttc accagccgat ctcacaaaat tattgcggga acaccgatga agcgcttcgg 1307281 aaaaccggag gatttgctcg gtacgctcct ttggctggcg gatgaatcct attccggttt 1307341 tgtcactggg atcaccgttc ctgtcgatgg aggatttatg gcttattcag gtgtgtaacg 1307401 aaagcggtgc aacagaaact gaaccaacat aggggtgagg ttgagatgtt ttcaaaagat 1307461 aagcttcccg ttatcctttt tttgttcctg gcaggggtga ttaattacct ggatcgctcg 1307521 gcgctttcca ttgcagctcc ttttattcag gatgatctca cattgtctgc cacacaaatg 1307581 ggcttgattt tcagcagttt ttcgataggt tatgccattt ttaattttct tgggggcgtg 1307641 gcatccgacc gctatggggc aaagctgacc ttgtttgtcg cgatggttgt ttggtcgctg 1307701 tttagcggag cagtcgccct cgcttttggc tttgtcagcc tgctgattat acgcattctc 1307761 ttcggaatgg gagaaggccc gctttcggcg accatcaaca agatggtgaa caactggttc 1307821 ccgccgaccc agcgggcgtc cgttatcggt gtaaccaaca gcggcacgcc cctcggggga 1307881 gccatttccg gcccgatagt cggcatgatc gcagtggcgt tcagctggaa ggtatccttc 1307941 gttctcatta tgattattgg attgatatgg gcagtgctct ggttcaagtt tgtcaaagaa 1308001 aagccgcaag agacgatcaa ggaagcaccg gcaataaaag cagaaacgtc tcccggagaa 1308061 aaaattccgc tcacctttta cctgaagcaa aaaacagtcc tgttcacggc gttcgctttt 1308121 ttcgcttaca actacatcct cttcttcttt ttgacatggt ttccgagcta tcttgtcgac 1308181 gagcggggat taagtgttga atcgatgagt gtcatcacgg tcataccgtg gattttagga 1308241 tttatcgggc tggctgcggg gggatttgtt tctgactatg tgtacaaaaa aacggcccga 1308301 aaaggtgtgc tgttctcgcg caaggttgtg cttgtcacgt gtttgttttc atcagctgtc 1308361 ctgattggtt ttgccgggct tgtggcaacg actgcggggg ctgtcactct tgtcgctctg 1308421 tcagtgttct ttctttattt gaccggtgct atctattggg ctgtcattca agatgtggtt 1308481 gatcaaaaca atgtcggttc tgttggcggc ttcatgcatt tcctcgccaa cacggcagga 1308541 attatcggcc cggctttaac cggatttatt gttgaccaaa caggcacgtt ttctggagca 1308601 tttttgcttg ccggtgggct ggctgtcttc gcttcacttg ctgtgattcg ttttgtccgt 1308661 ccaatcattg gtaagccagc gggaacagaa gctgagaatc ctgtgtctta ttaatctgga 1308721 aatatagtgg gagaggcggt atgtttgatg atacaatata cagtaaataa tcgcagccgg 1308781 tatgataagg aagggaatta gatggtaacc ataaaagata tcgcaaaact cgcaaacgta 1308841 tcccacacta ctgtttccag agcactcaac aacagccctt acatcaaaga acatacgaag 1308901 aaaaaaatat tagagctagc agagcagctc aactatacac caaatgtaaa tgcgaaaagt 1308961 ctggcgatgc aaaagtcgca tacgatcggg ctattcttta caagcattac aaacggaacc 1309021 tcacacagct tctttgcaga cactatcaaa ggcgtcaatc aagccataag tgaggattac 1309081 aatctgtatg tgcgcggcat tgatgatctg aaaaactatg actccgttac accgatgaga 1309141 tatgacggca tcattttaat gagccaaagt gacattgata attcttttat ttaccatatt 1309201 cgcgaaaaaa acattccgct tgtcgtgctg aatcgtgata ttgatgatcg taccatcacg 1309261 aatattttgt ccaatgacaa ggaaggctct caagaagctg tagaatactt cattcagtcc 1309321 ggacatcaag acatcgccat catcgagggg atcgaaggct ttaaatcctc ccagcagcga 1309381 aaggaagggt acttatccgc actgattcaa catcatattc cgatcaagca tgaatacagt 1309441 gtcaaaggac agtacgatat ggaaagcggc tttcaagcga tggagcggct gctggcactg 1309501 ccgaatcctc caaccgctgt tttttgttcg aatgatgaca tggcaatcgg agcgatgaat 1309561 gcgatattcg caaagggcct gcgcgttcct gatgatattt cggtgatcgg gtttgatgat 1309621 attgggtttt cacagtacat cacgccaagg ctttcaacag taaagcgccc agtggagaaa 1309681 ataagcgtgc tcggtgcgca aaaactcttg tcgctgatca gcgagcccga aacaaaagca 1309741 gaaaaaatct tggaaaacac agaatttatg gtgcgtgatt cagtcagacg attgacgacg 1309801 tgatgtcccg tttttcagcg ggcattcttt atacagaaaa atgttaacgt gtgcataaag 1309861 tgagagggag gcaataaggg tgcagaagct gaataaaaat gtgtacgatc actatactca 1309921 gtatccagaa aaaattctcc aattcggaga aggaaacttt cttcggggat ttatcgattg 1309981 gcagattgat caattgaatc aacacactga ttttaatggg agcgtggcag ttgtccagcc 1310041 aagaggctca gaaaaaatca aacgattaaa tgagcaagat ggattatata cacttttttt 1310101 acaaggaatg aaagacggag aagcggtaaa cgagcatatg attatcaact caatcagccg 1310161 gggaattgac ctgttttctg attatgaagc atacaaagaa ttggcatcaa gcgaaaggct 1310221 tcggtttatt atctccaaca ccactgaggc tgggattgta tgtgatgaaa aagatcgttt 1310281 agaggatagg ccgcaaaaaa cattccctgg gaaattaact gcatttcttt actttcgcta 1310341 tcaggctttt aaaggagatc agacaaaagg gtgtgtcctg atcccatgtg aactgatcga 1310401 gaataacggt gaaaagctga gggaaacggt tcttcattat gcacatctgt ggaagctgga 1310461 ggaaggattt acacagtgga ttcatgaggc caatacattt tgtaatagtt tagtagaccg 1310521 gattgttccg ggttttcccg tcgacagcat tgatgagatc acggcagatc ttggctatca 1310581 ggatgatttg atagttgtgg gagagcaata ttatttgtgg gttatcgagg ggcctgattg 1310641 gattggaaaa gaacttccct ttgcggctgc agggctgcat acaaagatcg tcagcgacct 1310701 caccccatac cggactaaaa aagtaagaat tttaaatggc gctcatacag caatgacgcc 1310761 agtggcttta ttatacggct tgaagactgt tagggatgca gtcgagcatc cggaagtggg 1310821 gcgatttata agagagctga ttgatgacga aattcttcct gttttaaaaa tggaaggtct 1310881 ttctcagtat gctgacgatg tgctgaaccg ttttaaaaac ccgtatatta agcattacct 1310941 ggaaagcatt gcattgaacg ccatttccaa attcaaaacg agaaacctgc cgactcttaa 1311001 ggaatatgct gaacaaaagg gacagcttcc tgaacgcttg gtgttttctt tcagcgctct 1311061 tctgtatttt tatcatgata acgagacatt gcaggatgat ccggcagttc ttcaattttt 1311121 caaagaggtt tggtgtcagg aggatggcga catgcttcgg attgcatcaa gagtgttagg 1311181 cgaacagcgg ctgtgggggg cagatctcaa tgagataccg aagctgactg atagagtcgc 1311241 tgtttacttg aatcatattc atgagctggg catgcagagg gctcttgaac aatactgcat 1311301 acaaggggga gaggtacgtt gaagtcgttt ataaagattc ataagcaaga taatgtcctt 1311361 cttgctctgc gggatattca aaagggagag aggctgcatg cttacggcgt gtcgattgaa 1311421 gtaaaggatg atataaaaag aggccataag attgcattgc agtctatcaa agaaaacgac 1311481 agcatcgtca agtacgggtt tccaatcggt catgcatcac aagatatctc gatcggagag 1311541 catattcatg tccataatac gaaaacaaac ctgtctgata tccaattata cagctataca 1311601 ccgagatttg atgaaaatcc gtattctaat gagaaccgga cgtttaaagg ttttagaaga 1311661 gaaaacggag atgcgggtgt acggaatgaa ttgtggattg tcccaactgt cggctgtgtc 1311721 aatggaatag cagaaaaaat gctgcagcgt tttgtcagag aaacagggga tatcgctcca 1311781 tttgataacg tactggtgtt aaagcatcaa tacggatgct cgcagcttgg cgacgatcat 1311841 gaaaatacga agcagatcct gctgaatgcc attcgccatc caaatgccgg cggcgtcttg 1311901 gtgttagggc ttggctgtga aaacaatgag ctggcaagaa tgaaggaagc actgcaagat 1311961 gtgaacttga agcgggtgaa gtttctggaa tcccagtcgg tgaccgacga aatggaggca 1312021 ggcgttgctt tgctgaagga aattcatgaa gcggccaaag gagataagag agaagacatt 1312081 ccgctgtctg aactgaagat cgggctgaaa tgcggaggtt cggacggttt ttccggcata 1312141 accgcaaacc cgctgcttgg acgtttttca gattatctca ttgcacaggg agggagtact 1312201 gtgctgacgg aagtaccgga aatgttcggc gcagaaacca tcctgatgca gcgggctgcc 1312261 aatgaagaag tgtttcataa gatagtcgat ttaatcaatg atttcaaaca atactttatt 1312321 aaacatgatc agccggtgta cgaaaatcct tcaccgggca acaaagcggg cggcatttct 1312381 acacttgagg ataaatcgct gggctgtacg caaaaagcgg ggatttctcc tgtcacggat 1312441 gtcttgaaat acggtgaagt actcaagaca aaagggctga ctcttttgag cgcaccgggc 1312501 aatgatttga tcgcctcctc cgcattggcg gctgccggct gccaaattgt cctctttaca 1312561 acgggaagag gcacgccgtt tggcaccttt gtcccgacgg tgaaagtagc gacaaacacc 1312621 gagctgtatg aggcgaagcc gcattggatt gattttaacg caggcctttt agcagaggat 1312681 gatgttcatg aggaatatgt gctgcgtgag tttatccact atatgattga ggtggcaagc 1312741 ggccagcttg tgaaccatga aaaaaatgat ttcaaagaac tcgccatttt taaatcgggt 1312801 gtgacgttat aataagaaaa ggctatcctt caagcggata gccttcttca ttaaatcaat 1312861 tttaaaccgc tgactaaaat aatggaagcc ataataaatt gcagtggacg cggggagaat 1312921 cgaggcgaaa gatggctccc gatcagtacg ccgggaattg aaccgaggag cagattagct 1312981 gccagcatgt aatccacgct tccgaagctt gcgttcaaaa tgcctgctgc cgtaacaaga 1313041 agaaaagcat gcgcgatatc ggttccgaca atctgtgacg ctttcatgtt aaataagtaa 1313101 atcatggcga ttgcaaataa tgagccggac ccgattgatg ttaatccgac gataaaccca 1313161 aacacaacac caataagaat tgtcagcgcc ctcttatttt caagcggcat cagctgccag 1313221 cggttggggc gaagttttct atccaaaaac aaacgaacga tgattgaaat ggcaaccagc 1313281 gttaacacat atcctagagc gtgcttaata atttcttcct gatgctggtg aaaggcgggg 1313341 aacaaatgca atatgccaat ggctagcgaa gcactcggaa tactgccgat ggctaagtat 1313401 tttaccaatt taaagttaat cgttttctgc cgccaatggg aggcaacgcc aaacagcttt 1313461 gtgatcgagt tatatacaag atccgtaccg accgcgatgg aaggattaat tccaagcaca 1313521 attaaaaggg gagttaataa ggccgctcca cccactcccg tcaatccgac taaggctccg 1313581 acaaacaaac ccatcaatat gatgcttaca ctcatgataa aggcctcctg aaaacccgac 1313641 tatttttatc agattatata tgattaggac gcgttaatca attaaatttt ttgaattttt 1313701 gcacgttagt tgcttgaaat tttggtatgc tcaatatctc tattcatttg ccctataatg 1313761 agtgtctgga cgaaatcgag aagtactaaa ggcgcaaaaa aaagatacct cttaacaggt 1313821 atcttttttc ttgtttacgc tacatgcgct gctgatagaa aggaagctca gtgtggccca 1313881 tttcccgcac atacacgaac aggttgcctt tatggtgaat ttcatgctcc attgcaagct 1313941 gaagcagcgc gcggcctgtg acttttctgc cgaaagcgga tgtcagatca atttctctgt 1314001 ccagctgctc ttcagtcagc tgttcaagga tagcgaccgt tttttctgta tatgtttttg 1314061 ccagaacatt gagatctgtt tctgtttctt cctgcttgtt ttgaaatggt gaggcattgc 1314121 cttccttaat gacatttgcg aacaagtgga aagacgtaag aatgtgtttg accagctctt 1314181 ctgctgacat tgatgtttct gccggtttgt agctgtaatg gtctttgctg attttttcgg 1314241 caagctcatt ggtcacgttt cgatgggata aaaaatggct gacaatttga ttggattggc 1314301 acattatgat ctcctccata tgtaaaaata aatggtgcaa tgaaatccta tatcaacggt 1314361 tatgaattca caagtaatat gctgtgggat gaaacaaaat gctatgtcaa tcgtatatat 1314421 aacgttcaca aaacatgaaa tggagtataa acatgactaa catacctttc atttatcagt 1314481 acgaagaaaa agagaatgaa agagctgcgg cgggctacgg cactttcggt taccttatca 1314541 cacggattga agaaacgctt tatgatcaat acggtgtatt ctatgagctc tatgccagtg 1314601 atgatccaaa tacggaatac tgggagcttc ttgtagaaga tgtccgcagc ggttcattgg 1314661 agcctgagca tgtggcatat atatttgaaa agcttgaaaa gaaaaccttt gcttacgatg 1314721 aagatgagaa agaaccggat tataccgtcc ataagtctat aagaaacagt gtatacgcgt 1314781 atcctgaaaa gggagttgct tttgccagaa ttccatattt tcaagatggg agcattatga 1314841 gttttgattg tctgtttgcg gttaacgatg aaaagatgcg tgcatttctg gagggagtca 1314901 gaccgcgtct ttgggaaaaa agcaagcgga aagtgaccgt gtttacggat ggagatggag 1314961 ggacttcaag agagcaggaa gccattgtca gagaggttca gcggagtcaa gtcatcatga 1315021 atccgctatt gaaaaaagag atatacagat caattgatca gttttttcat agtgataaat 1315081 cgttttatca aacatatgac atcccttaca agcgcggcat tctgttatat ggacctcctg 1315141 gaaacggaaa gacgacgtta gtgaagtcga tcgcaggcag tatcgatgca cctgttgctt 1315201 attggcaaat tactgaattt acgtcgagcg agacaataga agaagtcttt caggcagcga 1315261 gacgcctcgc tcctgcagtt ctggtcatcg aggatataga ttcgatgccg gaagatgtgc 1315321 ggtccttttt tctcaatacg ctggacggcg cgacatcaaa agaggggcta tttctcatcg 1315381 gtacgacaaa ctatcccgaa gagatcgatc caggtttgat gaatcgtgca ggacgatttg 1315441 accgtgccta tgaaatcggg cttccggatg aagagctgcg gctggaatat atgaaaatga 1315501 gaggctttgg catctttttg agtgaaggag aaataaaaaa cgccgcaaaa cttacagaag 1315561 gcttttcctt tgcacagctg ggagaattat atgtatcttc agcccttcaa tggcaccaag 1315621 aagggaatca ccatattgaa accatggtga aagacatgac aggagagcaa agaaaaagcc 1315681 agcggggaag ctggatggaa agaaacaaag tcggttttca ctaaaagaaa gcacgggtgt 1315741 ttgaaaaacc cgtgcttttt tgttgcggtt agccgaaatt cgacaattgc ggttattttg 1315801 cgttcttctt tttcttgtaa atatgataaa atatgacata tctcgggtaa ttcaaaaggg 1315861 gggattaatt gaggatgaag cagacgattc cgtcctctta tgtcgggctt aaaattaatg 1315921 aatggtatac tcatatccgg cagttccacg tcgctgaagc cgaacgggtc aagctcgaag 1315981 tagaaagaga aattgaggat atggaagaag accaagattt gctgctgtat tattctttaa 1316041 tggagttcag gcaccgtgtc atgctggatt acattaagcc ttttggagag gacacgtcgc 1316101 agctagagtt ttcagaattg ttagaagaca tcgaagggaa tcagtacaag ctgacagggc 1316161 ttctcgaata ttactttaat ttttttcgag gaatgtatga atttaagcag aagatgtttg 1316221 tcagtgccat gatgtattat aaacgggcag aaaagaatct tgccctcgtc tcggatgata 1316281 ttgagaaagc agagtttgct tttaaaatgg ctgagatttt ttacaattta aaacaaacct 1316341 atgtttcgat gagctacgcc gttcaggcat tagaaacata ccaaatgtat gaaacgtaca 1316401 ccgtccgcag aatccaatgt gaattcgtta ttgcaggtaa ttatgatgat atgcagtatc 1316461 cagaaagagc attgccccac ttagaactgg ctttagatct tgcaaagaaa gaaggcaatc 1316521 cccgcctgat cagttctgcc ctatataatc tcggaaactg ctatgagaaa atgggtgaac 1316581 tgcaaaaggc agccgaatac tttgggaaat ctgtttctat ttgcaagtcg gaaaagttcg 1316641 ataatcttcc gcattctatc tactctttaa cacaagttct gtataaacaa aaaaatgacg 1316701 ccgaagcgca aaaaaagtat cgtgaaggat tggaaatcgc ccgtcaatac agtgatgaat 1316761 tatttgtgga gctttttcaa tttttacatg cgttatacgg aaaaaacatt gacacagaat 1316821 cagtctcaca cacctttcaa tttcttgaag aacatatgct gtatccttat attgaagagc 1316881 tggcgcatga tgctgcccaa ttctatatag aaaacggaca gcccgaaaaa gcactttcat 1316941 tttatgagaa aatggtgcac gcacaaaaac aaatccagag aggagattgt ttatatgaaa 1317001 tctaaatgga tgtcaggttt gttgctcgtt gcggtcgggt tcagctttac tcaggtgatg 1317061 gttcatgcag gtgaaacagc aaacacagaa gggaaaacat ttcatattgc ggcacgcaat 1317121 caaacatgat gcataaaaaa agacccttag ggctttttat ttcttcagct tccattcttt 1317181 tatcgtcagc tcagaagatc cacttgccac cagcggatcc gcatggccga tttccgctgc 1317241 ctcttccagt gaatctgctt cgatgacata cgctccgcct gtggcgtcgc tgaatggccc 1317301 aaacattttt aaacgttttt ctgcctgtaa acgatccaga aattcatagt gcccagccac 1317361 atgctcctga ttaaatttct ccgttctcat tgtcagcatt aaatatgtat acatattcag 1317421 accctccgtg aacttcagtt taacacattt atccatatta cggtgataga tgatatgagc 1317481 ttttcgtcct acgaatgcca cctatttatg aaaaaagaaa aggagagatg ataggtgagc 1317541 attccagtaa agaaaaattt ggtttctgag gcgaaatacg cgttgaagtg tcctaatgca 1317601 atgtccgctg aatacattac cattcacaac acggcaaacg atgcatcagc ggccaatgaa 1317661 atcagctata tgatcgggaa cacaagctcg acaagctttc attttgcggt cgatgatcaa 1317721 gaggtgattc aaggtctgcc gcttaaccga aacgcttggc acactggtga cggcacaaac 1317781 ggtccgggaa accgcaaatc aatcggtgtt gagatttgct acagcaaatc gggaggcccg 1317841 aagtatgagg cagctgaagc cttggcgatt tcatttgttg cacagctgtt gaaggagcgc 1317901 ggctggggca tcgatcgggt gagaaagcat caggactgga gcggaaagta ttgcccgcac 1317961 cgcattttat cagaggggcg ctgggatcaa gtgaaggcgg cgattgaaaa ggaattaaac 1318021 gggggcgtat cagcgaaaaa agctgcagtc tcttcttcgg cgtctgaata tcatgtaaaa 1318081 aaaggtgaca cactgtcagg gattgccgca tcacacgggg ccagtgtgaa aacgctgcaa 1318141 agcataaatc atatcactga cccgaaccac atcaaaatcg gacaggtgat caaactgcct 1318201 cagacggcat ctgcttctaa aagccatgcc gcatcctcat atccgctccc atccggcgtg 1318261 atcaaagtga caagcccgct gacgcaaggg acaaaagtaa agcaggtgca gactgcttta 1318321 gccgctcttt atttttatcc tgataaagga gcgaaaaatc acggcgttga cggcgtttat 1318381 ggcccgaaaa cagctaatgc agtgaaacgt tttcagtctg tcagcggttt aacggctgat 1318441 gggatttacg gtccgaaaac gaaagcgaag atggaggaaa agctgtaaat gaaaagacgg 1318501 aagctgtgaa gcttccgtct tttcgcctta catacaaact gcggcaagca ccttttgaat 1318561 atcataaatg ctttcatctt ttttaaactg ctttgagaca gcgggaagtt ccgcgccgga 1318621 gatccaaatt ttcagctctg aatcaaggtc aaagcggccg gcagtttcca cgctgaatct 1318681 ggaaatgctt ttgtacggaa tcgattgaaa ttccgttttc ttgcctgtaa ttccctgttt 1318741 atctacaagg ataagccgct tgtcagtaaa gacaatcaaa tcgcgaacca gcttaaacgc 1318801 ggcttcaacc ttctcaccct caagtaaaat atgggcaagc tcttcttgca cagctgccgt 1318861 tgacagtgtt gatgcattgc cgagtaatcc atcaataaac cccatcatat acctcctctg 1318921 cgtattctat caaatcatac tataaaaaag gttttcattc atagatgagt agagtaaact 1318981 ggtgctgact ggtaaagggg ggcgttcaag atggaagata tgtatgacag ctttgcggcc 1319041 ctttctgctt ctgagtcgga gtaccggatt atttatgagg agaaaaacgg aagtgagctt 1319101 atcgtcctcg gtcctcacgg cggcagaatt gagcctggcg tcagtgaact ggtgcgggca 1319161 ttttcggatc gatgttccat ctatttgttt gagggtctaa agcagcgaaa caaccgttcc 1319221 ttgcatctca ctagcattcg ttttgatgag ccgctggctt tagaaaaagt gaatgaccac 1319281 cattacgcat tagcgtttca cgggtattat gatccgaaaa tcccgcatac attggtcggc 1319341 ggggcggatc gtaaaaaagc caagctcatt tgtgagcgtc tgaatgaagc gggttttagc 1319401 gccgagctca ctaatgagaa agaccgcctg gcaggtgtac acccaaacaa tattgtcaat 1319461 cggacgaaaa gagaaatggg actgcaattg gaggtaagca cggcacagcg aaatgcgcta 1319521 ttccgcaatt ttgggtgccg tgataaaagc tacatacaaa acgatttgtt tgatcgatat 1319581 gtggaagccg tcaagcttgg cttttataca taaaactaga cgggacctgc acggttggcc 1319641 tattccttca tacgctgggg ttgtgcgaaa gtgtggggag gaatgattca tgttttatca 1319701 tataaaagag cttcaatatc aagcaaagcc agctcatccc gatccggttt atgcgaaaaa 1319761 acttcaagag gtgctcggcg gccaattcgg tgaaattagc gtcatgatgc agtatttgtt 1319821 tcaagggttt aactgcaggg cggatgctaa gtataaagat ttgttatatg atgtggggac 1319881 cgaagagatt gggcacgtag aaatgctggc aacgatgatt tccaggcttc tggacaatgc 1319941 acccgcggat gtacaggagg atgcttataa aagcaatccc gctattgcag cagtcatgtc 1320001 agggatgaac cctcagcacg cgattgtgtc cggattgggg gcgatggcat cagatagtga 1320061 gggctatccg tggaatgcaa aatacattat ctcaagcgga aacctgctgg ccgattttcg 1320121 cgctaactta aatgcggagg cccaaggacg ccttcaggtg acacggcttt atgccatgac 1320181 cgatgatcca ggggtaagag atatgctgtc atttttgatt gcaagggata cctatcatca 1320241 aaatatgtgg tacgcggcca ttaaagagct ggaggaaaga gaacgggata ttgtcgtccc 1320301 gacgacgttt ccgcgtgagc tcgaaaagca ggaagtctcc tatgacctgt ttaacttttc 1320361 caggggagat gaaagctcac aaggaagatg ggcacatggg gaagcctttg acggccgggg 1320421 tgaattcagg tatatcccgg ctccgattgc gttcgcatct gcgcctcatc ttaaaccggc 1320481 gcccatgtgg ctgcataata cagttccccc aatgtcgaaa tgttaggttc tcttctgggc 1320541 tgaggaatat atcctcagcc cgtatttgat cagatgtttt taccaatatg atataacgct 1320601 ttttcctcag cgacctgcaa gtgctgctga tcgccttcct cgtacgcatt tggccgcttg 1320661 tgagataata aataagcgag ccgcttctga aattgaatac ctgctttacg ccgttcaaac 1320721 atgtcaagcc ttttatcagc aaattccttt gttacccgga ataccgccgc aattgtggcg 1320781 agtgcctggc ttctccattg cggcagttcc atctgcaaca gcataaaggt tggcacacag 1320841 aagtggtaca taaattgatt tgcctggaat tcctgaagct ctctgaagag cttgttcatc 1320901 tgaaaatgat tgcctgcatg ctttaacacg tggcacagct catggccaaa atcctcccat 1320961 tgctcttccc gtgacttttt ttggttcaat acgatactgt acatgccgtc gtatttcacc 1321021 atcatgctcc ccatatcctc aaaatgcacc caaatatcca gatcctttgc gattttcagc 1321081 atgtcaatgt gatgagggga tgtgatgccc agccggccgt ataaattttt aacgtattcc 1321141 tccagatgtg ataagtaatc gcccaattga atactccctt tcgaacgttt gttctgtttt 1321201 tagcgagaaa gaaaagcccg tataggactg gaaggtagtg tagaaatctt tcccttttct 1321261 ttaaaaaata aacacttttt tctttatatc ggtctacttt ttatatgttt tagagaacag 1321321 agaacgattt atttattttt cggtttgcgg tttttctctt tttcttttaa atagttgata 1321381 aattcgatgg cctgctgttt gctttctggg gaaaaatcct gcatatcgcg gtatgcaagc 1321441 tgcaggtccg gatctgagaa catatcgtca tcggattttt tgtctttccc cgttaataag 1321501 taatcagtcg ttacttgaaa gtaatcagcc agcttttgga gtgtgtcgta atcgggttcg 1321561 cttcgcccgt tttcatagtg ggaatatcgt gcccgtgaca caccgatgtg tgatgcgatt 1321621 tcttcctgtg tccttttccc tctgagactc ttcaatctgc cgcctatcat actatgacct 1321681 ctctttttta aactccctac gttacttatg attatagata caaaatgtat caaaataaag 1321741 ttatgataaa aaaagtatca aaaataactt gatgatacag aatgtatcgt ttatacttgg 1321801 taacatccga tacaaaatgt atcaaaaaag atcaggagag tgatcacatg tatccgatcc 1321861 aaatcgtttt tagtgaaaat cccatagatc agcgccatct cggacaatcc ggcggcacca 1321921 tttcgtttac cgcatgcggc cttccggtgt ttcactttga aacgcaggaa cagtttcaag 1321981 catacatgat gttaaaagga gaagcggcgt acaatgaaaa acgataaaag ctatcctttt 1322041 ccgacgtatt cagggttgtt gaattcagaa cattatgaca aaattggccc ggcgttatgg 1322101 ctgtttctct ggtttatcag ctcaacaaca aaagaaatcg aaaaagacgg cgtaagctgg 1322161 ggcatcgtac tcggccataa gccgttaaaa gcgagagaaa tggcggcagt cttcggcgta 1322221 agtgaaaaaa ccgtcagaag atggctggag cttctcgaaa accatgatta cataaaggcc 1322281 gtccgtgcgc catacggact gatgatttcg gtcaagcatt caaaaaaatt cagcttcaga 1322341 tcggacaata ctgtacacgg gagtctaaaa gaacggccat tttcgccgca gacaccggac 1322401 acaaacgacc gtacagatat agataaaaca aacaaatata ctgctgctga tgatgcagtg 1322461 gatcacattg cgaagcggtt tacacaatta cggtcggctc aagaaggacg caccgtgtat 1322521 ccttcctcaa gagattatca agccatcgcc cgcattgttg ccatcggcgt tcctgtcacg 1322581 caaacaatca aatggcttga agaatgcttt caggcttttg aaaaccggcg gaccgccgct 1322641 tctgaaacaa tcaaggcttt tcgctactgc tcgaaattca ttgaagatcg atttttcgcg 1322701 cagcaagcca aaaagaatgc cgcaattcag catgagagga tgaaaaaaca tgacaaaacg 1322761 aacaatcgaa cagattttgg acgagctgag aagagggaga cgtccattac tggcggacaa 1322821 accggccgaa tcagacgcaa gcaggtatga ttgcctgcgc tgcaaggatc agggaggtta 1322881 tctcgtcagg cagaatggcc tggaagtctg gacgatgtgc agctgcatgg cagaacgaaa 1322941 agtgaagcgg ctgctgggtg caagtgagat tacccacgct ttcagacagc tcggcttcaa 1323001 ggaattccgc acggagggaa agccgcaggc cataaaagac gcatttgagt gtacaaaaga 1323061 gtatgttgcc gattatgaac aaatcaagga ttgccgaaaa aacagcattg cccttttagg 1323121 acagcccgga tcagggaaaa cacacctttt gaccgccgca gccaacgaat taatgagaac 1323181 atgctatgtg cctgtcattt attttccgtt cgtggaaggc tttactgatc tgaaaaatga 1323241 ttttgcccta ttagaagcga agctgaaccg gatgaagcag gcggatgtgc tgttcattga 1323301 tgatctgttt aaaccggtta acggcaaacc ccgcgctaca gattggcaat tagagcaaat 1323361 gtattcggta ctcaactatc gctacttaaa tcataaaccg attttgcttt cgagcgagct 1323421 gacaattgaa ggacttgtac gggtcgatga agcgctcggc acgagaatct atgagatgtg 1323481 cagtgactat ttagtgatta tcaaaggagc agcctacgag cttaaccata gattggaggg 1323541 cgtcagataa tgtgtaagct ttgtcaaaca aagaaagtca ttgtggaaca taccggtatt 1323601 ggagttgttt ttcatccatg tccgaactgc cggtccggca ctgacttaac gcctgtcatt 1323661 caaaagctgg agcaaatgct gacagcggga aaagcgaggc tgaatatcta tgattaaaca 1323721 gctgactgct ctaatcgctt tgctgtttcg ggcaaagcga acagaaaaaa acattgaaca 1323781 atggtataag gacgacggga agtgaaagtg ttggcaaaga caaaacaggc agagaaaagc 1323841 cctgcgccgt ggcgtgctgt cccgtgcggg gatacgaaac cgatctatat ttattcagct 1323901 tacagtgaag aagaaaaaga aagatttccg tactcaaacg ggcggctgat tgcagctgta 1323961 tttgacctca gctcttattc gcaaaaaagc aatgcctctt tgatggccgc tgcgcctgaa 1324021 ttgctggaag cgtctaaagc agcacttgat tttctgaaag ggaattctat tcattcaaag 1324081 gagcgtatca ttcagctatt agaaaaagct gaagcaagcg ctgcaccgaa aaggggagga 1324141 aataaaacat gattcatccg aaaaaactgc tgcatatcga ttccgtcacg cttaagagcc 1324201 agctggagga cgggaaaatc cgtgtcatta ttgtggacgg catcaagcaa gaagcatgga 1324261 tcacagaagc gccagagcat ggaaaaacgc tcgtcgaaac aagaaagggc gatcttgctc 1324321 gtgtggaatt tgaaatcggc tacaaattaa attaaagcga aaacagaata cgtccaagac 1324381 ggaaagcctg cggacactga tcaactgcac agcatttgtg cgttgattgg tgtccgtttt 1324441 ttatttgcca aaaatgagga ggatcataga atgcaagact tactatttga atataaacgc 1324501 acgctcaaac aaacaagaat acaatataaa ccgctcgctg aggcagatga atccgtgctc 1324561 tcagctgaag agctgaagga taaaaaaatc atcagaaata tgattactga tcttgaatat 1324621 gtaacagaat ggcttgaaaa aggaaggcag cccggcatca gacgggcgat tgaccggcgt 1324681 gatgtttacc agcggctgat gatcaaggac ccgagaatca tcgaatcatt ttccagcgct 1324741 atgatgtttg agccggacgg acaggtatca gaagaagaca gagatagaat tcgagaagca 1324801 ttagccctgt taacggacag agaaaaggaa atgtttttgc tgcataaggt agaatgtttt 1324861 tcttatgaac ggatcgccga tcttctcggc gtaaaaaaat cgacagtgca aacgacgatt 1324921 aaacgggcga gtttaaagat gcaaagacag caggaagaaa tgaatcgatc acttgcctga 1324981 aagcttgtca tacgtttgcc acctataagt gaatagagca tgacactaag cggctggctg 1325041 atcagccgct tttatgaata aacaaccatg ctggaggtgg cggtgatgca gtagcatgaa 1325101 aacacaacag cgcgaacaag cattagcaat ctatcaacaa catcaaggaa agatcacaaa 1325161 tcgggcgatt gcggacacaa tcggtgtttc cgcgaaaaca atcggcatct ggaaaaaaca 1325221 agacaaatgg aaagaggcgc tgttttctgc gtccaaaaac gaacaaaaac agcgccctat 1325281 aaacaacgat gaattaaatg aacgccagcg gctgttttgc ctgtattacg tcaaaagctt 1325341 caatgccaca cagtcagcaa tcaaagcggg ctattctccg gacagcgctc atgtgacggg 1325401 cagccgactc ttaaaaaacg aaaaggtcgc tgctgaaatt agacgcatta aaaaagaaat 1325461 ggtcaatgaa atgtttattg aagcgatgga tgtgctgcag gtttatatca agatcgcgtt 1325521 tgcggatatt acggactatg tgacctttgg aaaaaaagag gtccaggctg tcgggaaatc 1325581 gggtccgctg tttgatgaag atgataatcc gattatgaag gaaatcagct ttgtcgatgt 1325641 caaagactcc gggctcgttg atggcaccat tgtaacggaa gcaaagcttg ggaaagaagg 1325701 cattgccatc aagcttgcag ataaaatgaa ggcgcttgag aagctatcct tatattttga 1325761 tttgtttcca gatcaattta aacaaaaaat tgaaaatgag aaattgaagc ttgccaaaca 1325821 aaaagcggag aaaacagatg acagccagga gccgattgaa attatgatca aacgaaaaga 1325881 gcgcaagtca tgattgtaaa agaaatcaac cctcatttcg aagattacgt gttcaattgg 1325941 gagcagacgt accagtttct tgtcggcggc tacggctcat ccaaaagcta tcataccgca 1326001 ttgaaaatcg tgctaaagct gctgaaggaa aaacggacgg cccttgtgat ccgggaggtg 1326061 ttcgataccc atcgggattc gaccttcgcc ttgtttcaag aggtgatcga agagctcggt 1326121 ctcacaaagg ccgtggcatc tctttcttcc ccgctgcagc tgcgatttca caatggcagc 1326181 cggatcatgt tcaaaggaat ggacaatccg gcaaaattaa aatcggttca taacatttca 1326241 ttaatatgga ttgaagagtg ctcagaggtg aagtatgagg ggttcaagga gttaatcgga 1326301 cgtcttcgcc atcctgagct aaagcttcat atgatctgta ccaccaatcc cgtcggcacc 1326361 tccaattgga cgtataggca tttttttcgg gatgaacgca agaaacggtt tgtgctggat 1326421 gacagcgaac tttacgaaaa gcggacgatt gtaaagggag atacgtatta ccatcattcc 1326481 accgctaacg acaatctttt tctcccggaa agctatgtga aacagcttga cggactcaaa 1326541 gagtatgatc ccgacctgta ccggattgcc cgaaaaggac gattcggcgt caacgggatc 1326601 agggtgctgc cgcagttcga ggtactcccg catgatcaag tgaaaaaatg tatcgcagcc 1326661 atcagcaaac caatctttcg tacaggtatg gattttggat tcgaggaatc ctataatgcc 1326721 gtcgtccggc ttgctgtaga tcctgaaaaa aaatacctct acatttattg ggagtattat 1326781 caaaataaaa tgacagatga taggacggct gaggagctgc gtgagtttat tgagacacag 1326841 gaattgatca aagccgactc ggctgagccg aaaagcattc aatatttccg ccagcagggc 1326901 tttcggatgg ttggagccag aaagtttccc ggctccaggc ttcaatatac caaaaaggta 1326961 aaacggttca aaaaaatctt ctgttcggac cgctgtgaaa atgtcatcta tgagctcgag 1327021 acacttacgt atgccaaaga taaaaacgga gctctgattg aggatgaatt cacgattgac 1327081 ccgcatacgc tttctgccat ttggtatgcg cttgatgatt atgaggttgc tgatatgaaa 1327141 gagacagcac acaaacgaat gcggccgaac cgagaaagga ggaggtcata aatcatgcac 1327201 aaccaaacag tcagagcaac tgtatttaaa gccaatgccg cggctcctca gacaaagcaa 1327261 atctatgaag atgacttttc tgagctgtac ggagaggaca ttattgctcc gccctataat 1327321 atcatcgagc tcaaaaccat tgccgaatac tcgaccattc ttcagcaatg cattgatgcg 1327381 tacagagtga atattacagg ctttggattc gatgttgagt acacatttga tgtcaacgca 1327441 agtgatgtcg atcaggcaaa aaagaaaaga gcggaaaaag actgggccag actcgaagcc 1327501 ttttataaat gtcttcactt tgatgaatca gctgaaatga ttttaggcta tgccatcgaa 1327561 gacagagaaa aaacaggcaa cggatttatg gaagtgcttc gcgacggggc gggaaaacct 1327621 gccggcatcg aatatttaga tgtgaaatat atgcgtgtat gcggagcagg cgagcctgta 1327681 gaggtttcat ttgtatatga agaaaacggg aaaatgaaaa ggatcaaaag gcaaaaacgc 1327741 ttccgaaaat atgtgcagat gatcaatgga aagaaagtat tttttaaaga atacggcgat 1327801 ccgcgaaaaa tggatattcg cacaggtgaa tatgtaaaca cattggcaga gaagtatcaa 1327861 gcaaatgaag ccattcacct caaaatcgga agcggcgtat acggtgtacc ccgctggatc 1327921 ggcaatattg tcaatttata cggggcccga aaagcagaag agctcaattt tatgtatttt 1327981 aagcaggggc gtcacgtccc cgctgcgatt acagtggaaa acgggatgct gtctgaagct 1328041 tcttaccggg agctgcagga atacatgaat gatcttgaag gcgtggagaa cgcccataaa 1328101 tttctcctga tcgaagcgga aggaatcgca aaagaaaagg atctccacgg aggcgaggat 1328161 attacgccgg tttccgtgga aatcaaatct ttggctgaaa ttctccaaaa cgacgccttg 1328221 tttcttgaat acgatgaaaa aagcagaaat aagctgcgtt ccgcgttccg tctccccccg 1328281 ctgtatacag gcgaggccca ggaatacaac cgggcgacag cggatactgc tagaaaaatt 1328341 acggaggagc aggtttttca gccggagcga aaaactctcg tgaataaact gaacacgctg 1328401 cttttgccgg agctgaatat ccatgacgtc aggctgacat taaaaggacc ggactttcgt 1328461 gatccgcttg agattgcgaa ggtgctcggt ccttttatta cagccggagc agtctcgccg 1328521 aatgatttac gcgaccttgc cggacgggtg cttggcaaaa cacttgagga gtggccggag 1328581 gacatttata aacggcctgc aggacaggat gcggaaaaga caaacctggc tgcgctcatg 1328641 caggagctga aagaaagcat cgaagatatc aaaacgtcct gaagggaggt gaatcaagca 1328701 ggtggcgcga gaattaagaa atgccaaaat cagctttgtc agttatgtgg acaaggcggc 1328761 taaccagaca gaatttttct ttacgaagtc agccgaacct ccgtcatttg aaaaaaaggt 1328821 tcggctgttt acaaaaagtg agcaggatga acaaaagctc gtgtacggaa tcgtgtatga 1328881 gcctgatgtt cctgatgccc acggcgattt tatgaccgcc gaggaaattg aaaaagcggc 1328941 gcacggtttt ctcgcggagg cacgggagat tgatatcaat cacagctttg agggcggaac 1329001 cggcgtcgtg gtcgagtcct atgtggcgcc cgatgatttt atgatcggat caaagcggat 1329061 tacaaagggc tcatgggtac tcgtgacaag agcgtctgac gaggtgtggg aacagattaa 1329121 ggctggaatt atcaccggct acagcatggc tggcactgca gatgtgtatg aagaagaacc 1329181 ggtcgaaaaa gcagggttct ttagtgtatt caagcaaatg cttgctgaca aaacagggaa 1329241 ggagactgaa gaaatgagaa aagaagacat gaaagaatca ttcgagcatg cgctttaccc 1329301 tctgctcaaa cggcttgagc ggattgaaaa aaacacagac acggaggaaa agccggagca 1329361 gacgggtgat gacgagcgtc tgaaaaagct cgttgaagac atgcttgccc cgctgatcga 1329421 acgcatcgag gctttggaaa aagcgcgagg cgcgtctaag cagacagcgg acgatacggg 1329481 cggcaataca gagcaagtca aaaaatcaat ctggagcgga ctgctgtaaa accagtcaag 1329541 gaggaggaaa tcaattgaga aatcaagaga tcattcggaa agcggaaatg tcgctttctg 1329601 ctttaaaaag cggcgggctt atgaaccctg cgcaagcatc ggcttttatc cgcatggtgc 1329661 aaaacacgcc gaccattttc agtgaatccc gcgtgattca aatggaaaac gattcgcaaa 1329721 aatttgaaaa aatcggcttc ggccagcgta ttctgcgggc tgcgcaagaa ggaaaagcac 1329781 tgtcaaacga cgagctgaca gttccaacga caagcactgt ccagctgaac acgaaggaag 1329841 tcattgcgga aatcaacatt acgtatgaca cacttgaaaa caatattgaa aaagacggcc 1329901 tgcagcagac aatcatgcaa attttagcag agcgcgcagc agttgatatt gaagagctga 1329961 tcgttaacgg cgatacagca tcagctgatc cgtatctggc acagctggac ggcatccgta 1330021 aacaggcggt ttcccatatc gttgacatga acggtgaaga actgtccaga gcgacattca 1330081 agaagggctt aaaggcagtt ccgccgaaat atttgcgcat ccctcaggaa ttcagattct 1330141 atacgtctca cggcttagaa gttgaatgga aggaccgcgt ggcagaccgc cagacaaacc 1330201 ttggggacca agctgttcag ggcggcttgt caacagcatt cggcgtaccg gtcaaagggg 1330261 tatccaatat tcagccgtac acagtcggtg agggagacgc gcaatatgac gcttctgata 1330321 tcattctcac acatccgaaa aatatcattc tcggcttctc ccgcaatatc cgaattgaag 1330381 tcgacaaaga catccgctcc cgtaaattca ttattgtctt aacggccaag ctggacagca 1330441 agttcgagga agaggatgcc tgcgcgaaat taattaacgt aaaagaataa tagaaacgag 1330501 gtggtcagct catgctcatt gaaccgactg acgtagcttc ctattcggtc tatgatcggg 1330561 tgaaaaacag gccggaagag ctgctggcgc aggatatcat cgaggcggaa gcagaagcgg 1330621 ctctcatcac gggccaccgc tttgaagaca gcttgtatga tccgctgccc ggcaaggtga 1330681 agttggcttt agtaaagctt gcccagtatt ttgcgcttgt caacagcgat gaatctgcct 1330741 catcaagcta tcagtatgag aaaatggggg attattccta cacggtttcc ggagaaggca 1330801 ggattcagcg gcctgaggtg tatcatttgc tcgaagagtt tattaagccg ggctacgtcc 1330861 ctgaatcctc cagactgaag gtgagatctt tatgagctac aggcagatgc tcattcaccg 1330921 ctgcgatatt tatcatgaag cagcgcaagc gccgtctgca ggccgatttg ggattccggc 1330981 agacaggctg cagccggtga tttcatatcc ggatacaccc gatgaacaag atgtcccttg 1331041 ttattttacc gaaaaaacac agcagctgat tcaggaggag ccggatcaaa ctgtatatca 1331101 tagctttctc gtccattttc cgttgtcagc ggacatccgc gtgaacgata aaatcatttg 1331161 ggagaatcat aaatatatac taaagctgcc gaaaaggatc agacatcatc attgggaggt 1331221 cgtcgcagtc agggatgaaa gcctatgaaa atagcgggat tgaaacagct gaacacggca 1331281 ttaaaagaag cggcttcagg cggtttttcc agacaggcgt cccggtggct tgaggagtgc 1331341 gggcaagatt ttctagagat cgtccaatct gaactcatca gcacacaaac gattgataca 1331401 gaaaaactgc tcagttcctt tgagaaaggc gcagaggaca atctctggat tgtgcaaagc 1331461 ggcgggcttt cgcttgaggt ggggacacag cttgattacg cctcatttct taatgacggc 1331521 cattggacgt caaaacaaga tgtgagatgg gtgccggggc gttttcaagg ctcacggttt 1331581 atttatgatc cagcggcttc aacgggaatg gcgctcaaga gaaaatggat accgggcacg 1331641 ggctactggg atcatgcact gcttttatat gaacagctgt ttgaaaaatc gctggaaagc 1331701 aaactgcgcc agtggctgaa gaagctgtaa aggaggagca ggatgaacag tgaaacagga 1331761 tcgatcatgg cgtttttgta cagccggtgg tctgttccca tttatgaacg cgagcttcct 1331821 gatcactttc aggtgccgtc gttatatgtc ccgccaccat ctgttttcga ggaaacagat 1331881 acggtctcca catttaaaaa aacctacagt ctcaatgtga aactgtttca tctggactcc 1331941 gttcaggcgc tggatgaagc ggacaggctc gcggatgcca tcagagaagc gagaaatatg 1332001 attccgctgc tgagtgaatc cggcgagaag acgggggata tggttcgcat ctcccaaatc 1332061 gagacaaggg taggggacag gggcgaggcg gccatggtga tcaggtggag cagcagatat 1332121 tattatcaca aaacagaaca gcctgtctta caggatatcg acatgaacag cggggtgaaa 1332181 taaacggtgt caaaggacaa acaacagaag aaggctgtac atacaaagag ccgggaagct 1332241 ctatttgata cagcggattt gattaagcac gcgaaggaac tgttcggcgt taagccggat 1332301 attcttcagg gggctttatt tggcgtggat caaccacgta tgacgaaatc agaagccaac 1332361 caattgattc aaacatttct aaccaaggag gtcatgtcat catgaatggc ggaacattta 1332421 caacaggcaa agaaaaagaa cgtgcaggca tttattttaa ctttaaaacg acggcacagg 1332481 agcgggtatc actcagtgaa cggggaacag tcgcacttcc ggtcgcctca agctggggcg 1332541 aagcgaaaac gttcgtctcc atttccagcg ttgaagacct aaacaaaaaa gtgggcctca 1332601 gcattgatga cccgtcttta ttgctgctgc gtgaagcgaa gaaaaatgcg aaaacggtat 1332661 tgatgtaccg tctaaccgaa ggtgtccgag cgtctgctga tattgctgaa ggcgtcaaag 1332721 caactgcagt atatggcgga acaaaaggaa atgacattat catccgcatc aatcaaaatg 1332781 tgctggatgc taattctttc gatgtgacaa catatatgga cgaatcagag gttgataaac 1332841 agactgtcaa aaaggctgaa gaattaacag ctaacggcta tgtcactttt accggaacag 1332901 gcgatctttc ttcaacgatt cctctcactg gatcagaagg agacactgca gctgagacgc 1332961 tgaatgcatc cgcgggcatc cgtttatccg gcggtacgga taaagcccct gtcaactccg 1333021 actatacaga tttcttagcc gcggctgaaa cggagagctt tgatgtgatt gcgctgcctg 1333081 ttgcagaagg tgaccagttg aaagcgacgt ttgctgcttt cattaaacgc ctgcgcgacg 1333141 gccaaggaca aaaagtgcaa ggcgtcacag ccaattatgc cggtgattat gaaggcatca 1333201 tcaacgtaac cgagggtgtg ctgcttgaag atggcacgga agttacaccg gacaaagcaa 1333261 cagcttgggt agctggagcg agtgcaggag caacctttaa ccaatcactt acatttgtag 1333321 agtacgaagg cgcagttgat gtgttacacc gccttgacca cgatacgatt gttgaacgtc 1333381 tgggtaaagg tgaattttta ttcacattcg acgcccgtga taaatccgtc agcgtagaaa 1333441 aggatattaa ctcactcgtg acgttcacag ctgagaaaaa caagaaattt gcgaagaaca 1333501 aaatcgttcg tgtcctggat gctgtgaata atgatttaac acgcgagctg aaagccttaa 1333561 ttaaatcaag aaaaggcagc ggaagcgata tcccggcatc tgaagacgga ctgcagtatg 1333621 taaaaacgat gatcacacaa tacatgacaa cgcttcagga cgcaggcggc atcactggct 1333681 ttgattccga tgaagatatc acaatttcaa tgaatgaaga tcgtgacggc ttcttgattg 1333741 acctggctgt acagcctgtc gacgcagcag aaaaattcta ctttaatgtg gaggtaaact 1333801 aatatggcat taaaagcaca aaacacaatc tcaggaaaag aaggccgttt attcctcgat 1333861 ggtgaggaaa tggcacacat caaaactttt gaagcaaacg tcgagaaaaa caagtctgaa 1333921 gtcaacatta tgggccgccg catgacaggc cataaaacaa caggggcaaa tggaacaggg 1333981 accgcgacgt tctacaaagt cacatcaaaa ttcgtgctat tgatgatgga ctatgtcaaa 1334041 aaaggcagcg acccttattt cacgctccaa gctgtgctgg atgatcaatc ctccggccgg 1334101 ggcacagagc gagtcacgct gtacgacgtc aactttgact ctgccaaaat cgcaagcctt 1334161 gatgtcgatt cagaagcgtt agaggaagaa gttccattta cattcgaaga cttcgacgtc 1334221 cctgaaaagc tatctgacac gttttaatca aagctgaatc agcccatacg cagacctttc 1334281 tcagaaaggt ctgtttttta aagatgaaac caaacaatag acaagggagt ttttttacat 1334341 gagcgagaag aacgaaaacg tatatgatct ttcctttttt atgccgggaa aaacaattga 1334401 agctgaggaa atcaaagtgc cgatctcaaa gcgttttgtt gataaaaaag ggaatgtcat 1334461 tccgtttatt ttaaaaccaa ttactactga acggattgat gaattagaga aagaaaacac 1334521 cacatttaaa aatgtgaaag gccgcggccg tgtcaaagat ttagactccc agcgctttta 1334581 tgcgagaatt gccatcgaat ctactattta tcctgatttt cgttcaaaag atttaaggga 1334641 agcatacaaa actgcggatc cggtagaagt tgccaaacgt gtattatctg ttgggggaga 1334701 gtatgcgaac tggctgaata aagcaattga aatcaatggt tttgaagatg atcttgaaga 1334761 tctagaagaa gaagcaaaaa actagtaaag gatggcgata aggaagctgt gtatttgtac 1334821 tatgcaatgc atgagcttca ttactcgcca tcccaacttc ttgaattata tgaagcacca 1334881 aaacatttta aagctctttt atttgggttg ataggttata agctagatct attagaaaaa 1334941 gaatcaagga gaggagggaa ctaatatcgc aaaattaaca gcccgttttg atctcgaaga 1335001 caaggtatct aaaaaactaa aacggataca taaaggattc caagaggtcg aaaaaaaagt 1335061 caaaaccatt aatcggcaaa tcaaaatcag tatcagagcg gaagatcagg cattttaccg 1335121 gctgagaaaa ataaacgact atatcatttt gaaattcgcg aaatcgcttg aaattaaagt 1335181 tgtacttgat gaccaagtca cttcaaagct tgatgcaatt gaaagaaaac ttaaacggct 1335241 gccgaaagaa acgaagctga ctgtctcttt ggtagatcgg acagcagctg cgtataaaaa 1335301 aataaagaag atgctttcta atcaaaagct atcattcctt ttgattccag atgacaaggt 1335361 tacttctaca gttaaaagga ttatcggtta tattaagaaa aatttgaaaa acggatacac 1335421 agtaaaacta aaggtcatcg atgaaatcac caaaacagtt aatcgattaa cagcccttct 1335481 aaggaaattt gaaaaaacct attatgtaaa agtggttgtt aagacaaaaa tatcagacaa 1335541 aatcaataaa aaagaaagcc tgattaacaa agaaacttct aagaaagaat cagacaaatc 1335601 ctcagataaa ggctctgata aaaactcaga tcaaaaacct ggatgggtcg gaaaaataaa 1335661 aggctggctg aaggattggt ggacaaaatc agcttggcct tggatcaaag atacgctcaa 1335721 tgaaataggc aaagcttttt tggatcgttt caaagagaga ttgatagaaa agctgaaaaa 1335781 tgatgtgttt gataagatca ttgataaaat tctaggacca caaaaaaagg acgattctgg 1335841 tgaaaattct gacacagata aaaaagtcct taaccgtaat acaggaggaa attgttgctg 1335901 tgactgctgt gaaggcggta tcagcccggg cactaaaaat aaaaaaacct atagaaaaaa 1335961 gaaaagtccc acaaaggctc caaacagaac actcaaggtt cctggagagg tgataagaag 1336021 acgccagagc ggcacacctg ctgaaagtgc acctaggacc tcgggttcca agttaaagaa 1336081 ctggcttgga ggcttaaaat cgctagggaa ggattcatct aaactaggta aagcgttcag 1336141 aggaatggga aaggctgttc catacgtagg atctgcttta gcagtgtttg atttagctgg 1336201 aatcaataaa gataatgctg gcgaaaaggt tggttcaatt ggaggacgta ttgccggagc 1336261 ggaagctggt gcaacagccg gagcggaagc tggtgcaacg attggatctt tcgttggtcc 1336321 ggaaggtaca gcaatcggcg gcgcaatcgg cggaattggc ggcgggttag taggcggaat 1336381 cggcggcgaa gaagcaggta agaacattgg taagatgttt gatacttcta agttaaagga 1336441 gagcataagc aattcactat ttaacaaaga gtggtggagt ggaaaatgga actccatttc 1336501 tgatactgcc aatggggcta ttacttggat tgaagataca tggagtaaag tttcaacttg 1336561 gtttgaccag tatgtgttta cacctatata taatgttgct gtacctgtaa ttaattttat 1336621 agtaggattg tttgcctatg cctgggatgg catattggca gtatggaaca ttgtctaccc 1336681 gtggtttaag gataacgtgt gggatccaat aagcggagca gttactaatg ttgctacaac 1336741 gatatggact ggattgtgca acgcctggac ggttatttca ggcatatggt ctactgtttc 1336801 aacatggttt atggacaatg tgtggaatcc tgtaagtgaa gccgtaacca ctgcggcaac 1336861 atggatttgg agtaagatca atgatgcatg gacaataatt tccaatattt ggacaggagt 1336921 atcgaattgg ttttatgata atgtatggaa cccgatcgtc aaaaaagtag aagatattaa 1336981 aacttcaata aaagaaaaat tcgatgatgc aaggaaattt tttgaggatg catgggatgg 1337041 aattgaaact tggtttaatg aacatgtgaa agatccattg gttaaagtat cagagaaaat 1337101 tgctgagaaa tttcaatggc tattcgattt aaaagattca gttggtggtt tcgttgcaaa 1337161 agtaatacac aggggggaag aagttactca cctcaagaaa aaaccaatca aaaaggattc 1337221 gaaagagaaa aaaactagtt ccaaaccaac tactaataac atttttgctc aatctccatc 1337281 aaataataat atgactgttt ttcaacaagc actagatcag aacgccacag gcggctacat 1337341 caccaaacca accatctcgt ggatcggtga agccggcaag gaattcgtta tcccggttga 1337401 taacaaccga ggccggggga agatgcttct ttcacaagcg gcgtctaagc tgggtatgca 1337461 agttgtagac gacatgggcg cagcttcgtc ttctggcgga agtccagcat ctgtttcagg 1337521 aggagcagct gtcagtcctc tatcaggcac agcctcccca gtaatgaaca ctgcaaatct 1337581 tacaggccaa gcgtccacac tcggacagca attttcagaa ggctttggta aaggcatcag 1337641 cgatcagccg gtcaaaatgg aagactggaa aaagaaaaac atcaatacac catttacaca 1337701 aatgatttct gcttcaccaa attacggtaa acaaatggta agtgggtatg ccaagggcca 1337761 aagcggcact gcaaccggaa cagacggctt tttgcaatca aaagttaaaa cgccgttcca 1337821 agccactgtg agcaaatcgt cttcatgggg cacaggaacg gtcaaaggct ttgcgcaagg 1337881 acaaaattca acccaaacag ggactgcaca gtatgtgagt acacatgttg acaaaccgtt 1337941 cctgcgttca aaagacacat cgaacagctg gggctccggt ttgattggaa actttgtgac 1338001 aggcatgaat tctaaatcca gtgaagtaaa acaagcagca aaggatatgg ccaagagagt 1338061 ggagcaggct ttccgtgaag aattagatat ccattcacct tctcgagtca tgatgagctt 1338121 ggggcgtttt gcctctgtcg gtgttgtaaa aggactggat tctgtcgatg tgaaaaaata 1338181 cgcagaaaaa caagccggtt cattggcagc tgcttattcc ggaatgggtg cagtaggggg 1338241 aaatgtgaaa cagtggctta tggcagcaat aatggccaca aagacaccat tgagctggct 1338301 ctcgggatta atgacgattg cacagtatga atcagggggc aacccgaact ctattaacct 1338361 gtgggatagc aacgcgaagg cgggaaatcc atcacaagga ctcatgcaga cagttccaac 1338421 cacatttaat gctcataaag caccgggcat gggtaacatt agaaatccga ttcacaacgc 1338481 tgctgccgcg atcggctata tcaaaagcag atacggctca attgataatg tacctggcat 1338541 taaaagcctg aaacgtggcg gtccttatgt cggttatgca aacggcgggc tgatcacgaa 1338601 agaacaaatt gcccgtgtcg gtgaaggaaa caagcgggaa tggatcatcc cagaggaacg 1338661 gggcatccgc ggtcgctacc ttcttcagag agcggcacag gctcttggta tggaagtgac 1338721 agatccgtct caatcccagc agtctgagct ttcttcagga caagtttcag ctgttacctc 1338781 ggctagccgg ccgactgcag cggtttctgg atcaaaagag atttatattc aatttaacgg 1338841 tgaccagcac ttccataatg gacaagacgc cgaaagccta gcggcgaaga tcaagcaggc 1338901 gcttatagat gaactgcaaa aggatatcaa tattggaacg aagggagtcg ttgcatttga 1338961 ctaaatccgt atatgaattt tggatttcac aagggaagga caagctgcgg ctccccgttc 1339021 ttcccgacca gctgagtatt tcaaatacag ttcagaatga gacggttaaa gtagccaagt 1339081 tcggtgacct tacatttatt gacgagcagg gagcgaaaga aatttcgttc tcttcttttt 1339141 ttccgaagaa atacagtccg atagcagaat atcaaaactt cccgtcgccg gaaaatgcga 1339201 taacaaaaat tgaaaaatgg atgaaggcca aaaaaccggt tcagtttttg attacgggaa 1339261 ctaaagtgaa tttaacatgc agtattgaag gtttttccta tagcgaaggc cagcaggata 1339321 taggtgatcg ttcctttgat attcaattaa aagaatacaa aaccgcttcc ccgcggaaaa 1339381 tcaagcagaa gaaaaaaaca aaggcaaaac gtccgtcgaa ggctgcgccg aagacgtaca 1339441 cagtgaaaaa gggagacacg ctatgggaca ttgcaggcag attttacggg aacagcaccc 1339501 aatggcgcaa aatttggaat gccaataaaa cagcaatgat caaacgaagc aaacggaaca 1339561 tcaggcagcc gggccactgg atttttcccg gccaaaaatt aaagataccg caatgaaaca 1339621 ggtgatgtat gatgatagaa ctgttcgtca ttaaagacac agagtggctt gagctggttg 1339681 cagaaagcgt atcgcttgaa ggccatcgtt atcaggcgcc gcgttccatt gaagcaacca 1339741 tcgtcaccaa gcagggcgac cagacgtatt acagtgtctc agaaggagat acggtcttgt 1339801 ttaaatggaa gggaaaagag ctgtttcggg gcattgtttt tgcaagaacc ccggacgagc 1339861 atacgcttgc cttcagcgct tatgacatgc tgcagtacct ggtcaaaaac caggatatgt 1339921 acgtgttttc caatcagcgg gccgaccaga tcatcagaag gattgcgagt gacttccaga 1339981 taccgacaac ctcgatcgca aacacaggcc atacgatcaa aagtcttgtc attaaaaatg 1340041 atacgacatt gtatgacatc atattaaaag cgctgaaaca gacgaaaagc cagacaggac 1340101 gacattacca gctgtattcg gaaaaaggaa agctcggcct gcgcgcttgg ccagatccgt 1340161 cagaggtatg ggtgcttgaa acgggcgtca atatcacggg ctaccaatac agcacttcta 1340221 taaacgacac tgctactcgg gtggtgcttc gccggcagaa ggacaataag acatataaag 1340281 cctctgccaa ggacagttca ggcttaaata aatacggtgt gcttcaatat acggaaacgg 1340341 tcacagatga catcaaccag gcacagcttc agcagcgggc agatgtacgc cttgctgaaa 1340401 aaaagggcgt gaaaaaagaa ctgaaaaata ttcaggcagt gggcatccca gaagtgcaga 1340461 gcggcttgcc tgtctatatt tcgattccgg aggccggcat caagaaaacc tattgggtag 1340521 atacggaccg gcatgaattt aaaggaacga aacatacgat gacgatcgat gttgtcgaaa 1340581 agaatacgat gccggaagga gtttcctgat gagattaagt gaggctataa aacatttggc 1340641 agtcggcgca gttgacgctg agtctccggt agaactgctc ccggctgaag tcgtttcggt 1340701 ttctcctgtg gaaatcaaat taaaagaaaa cagcaaactg atcataccgg aagacgccat 1340761 cattatccca aaacgaatgc agtccggagg agacgatgca ctcgagccgg gggatcgcct 1340821 catgaccgcg gctctgactg gcgggcaatc gttttttatt ttagataagg tatagacaaa 1340881 ccgcttcagt acgaaggggt ttttatttag catgtaaaag gagtgggcaa catggccctg 1340941 acaccagaag tggagtttga agatattgaa gttgagagcg aagtcattga aacctcgcaa 1341001 acgtacaaaa tagattttga aaacggaaga attacgaatg agctgattac cgggcttgaa 1341061 gcgatcaggc agttcgtgta tatcgcctta cagacagaac gctatgcata ttccatatac 1341121 agccataatg tcggaaacga gcttcaggac gtgctgacag atcatgagac gactgatgcg 1341181 tataaaaaga tggagattcc gagactgata gaagaggcgc tggtttatga tgaccggata 1341241 tctgctgtaa cagattttga gattgaaaaa caaggcgacg cgtttcatgt gtccttcgtg 1341301 gtggagacgg atgaaggaac gcttgagatt gaggaggtga ttggcgaaga tgtttgaaga 1341361 tcagactttt gaagcgatta tggagcgtat gctgaacagc atttccgcag atattgacac 1341421 aagagaaggc agcgtcattt ataatgcgtt agccccggcg gcggccgagc ttgcgaagtc 1341481 ttatatatgg ctggatactg tgcttgagct agttttttct gataccgcac aaggcgaatt 1341541 tttagacagg cgtgcagcgg aagcgggaat tgaacggaca gccgcgacaa aggcggtcag 1341601 agcgggagag tttacatctg gagttactat tcctgtcggc tcccgctttt acgtggataa 1341661 tctttatttt caatatacgg cagacgggac gctcatctgt gaaacacctg gtgaagcggg 1341721 aaacgccaat ctgaccggac gcaatttact gtcattggat accattcccg gtttagaaac 1341781 ggccattgtc aaagaaatcc tgattccggg gcgcgaggaa gagggagatg acagcttgcg 1341841 agaacggtat tttacaaggg ttcggcgtga ggccgtcagt gccaataaaa tgcattataa 1341901 agagtgggct gaggaagtgg acggtgtggg aaaggcaaag atcttcccgc tttggaacgg 1341961 tgaaggcacg gtcaaaattg tcgtcaccaa tgcgaatctt gagcccgctt ctcctatttt 1342021 aattcaaaaa gtgaaagatt atatcgaccc tgaaccagga cagggagagg gacaggcgcc 1342081 aatcggagcc gttgtcacgg tggaaagcgc ggtctggaag gaagttgaga tttctgccga 1342141 agtgctgcct gagatcaatc actcaattga tgaagtgaag tcggaaattg aggaaggcgt 1342201 tttaaacttc tttaaaaaaa tggcgtttga agacaacgtt atccgccttt ctcaaattaa 1342261 caatatcgtc tataattcac catcagtcag tgactactcc aatattcaaa tcaacggcac 1342321 gtctgaaaat ctggtgctga gcgacgtgga aattcctaag cttgggcagg tgaagatcat 1342381 tgagcaaaca agatgacatg cgagcttatc tgccgccgtt tctcaccagc cttaaagaaa 1342441 tggccgagct gctgaaagcg gaagcgcctg agtttgataa acaaaatgac agcatatttg 1342501 atctgacgga tcagttattc gtaccgacgg cgacttgggg gctcagccgc tgggaaaaaa 1342561 ttttaaacgt cccgcgggaa tcaggcgaca ctgatgagat cagacgattg cggctcattt 1342621 ccaaaatgtc gaacatcccg ccaatcacat acagggccat tgagcaggcg gtaaaccgtt 1342681 tcttgaaaaa cccgtctgca caggtccgcc tgcttcccgg cgaataccga tttaacgtcg 1342741 atatcaatgt tgatgacctc cagcacatga atgagctgat cgaagcgata gaaaacatga 1342801 aacccgctca tttggcgtat acgctcagag gcggattgaa tgagacgctg cgaatcaaag 1342861 atacagtcat cctgaatcac cgcagatacc gaacagccag tgagctcaag gtcggttatt 1342921 ctgtcactct taacaacaat gaggtggttt taacttgatt tcaaccatat acagagaacg 1342981 cacagcggct gatctaaaaa gcagaatcga tcacgtgctg ctcaacggcc aaaaaacaga 1343041 aatagtagag ctcgccattg acggtgcgac agtcaccgtt ctgacaaaac gtgaggaaga 1343101 catcaagcat attgaaacgg tacaaatttt tgacgagctg ggcaatgtga tcacagagag 1343161 aaagactgac ctggacgtca gcgaaaacag aacactcgat ttcagattta cttttgaggt 1343221 ggtgtaaaca tggcatacga agaaaaaaca gactggcttc cggacgaccc aatcaacgaa 1343281 gatgacgtca accgctggga aaaaggaata aaagacgccc acaccgacct ggctgcccac 1343341 aaaaacgaca tgaacaaccc ccacaacaca acaaaggcgc aaatcgggct ggggaatgtg 1343401 gataatgtgc agcaggcttc aaagacggaa tttaatgaac ataatcatga ttcaacccgg 1343461 catattacat cagtagaacg tgatgaatgg aatgcgaagg aaacacctgc cggagcccag 1343521 tataaggcag atcaagctga agcaaacgcc aaagcatata cagacaattt tgctgcacga 1343581 agagataatc ctaaccaagt aacaaaagca caggttggac ttgggaatgt cgaaaatgtg 1343641 aaacaagcct cactagcaga ttttgatgct catttaagca attctaaagt tcatgtatct 1343701 gaaggggaaa gaaacaaatg gaatgctgcc caactaatta aacttactgg agacgacggt 1343761 aaaagaatac aactccaaga cggtacagat attcttacat tatcttctgg attttattgt 1343821 gcagttggtc agtcagttgt aaacaacccg gtggaaggcg atgcagcttg gtataactac 1343881 gatattgtag aaggcggttc aggaaggaaa acaatagtag cttaccaaag ttggggaagt 1343941 atgatgtgga ttggaatggt tcacactgat ggagaattta gaggatggaa acaaattgca 1344001 acaacagatt ttatagatag agttcaaaca gaattagatc ttcatgaaaa tgataaaact 1344061 aatcctcatt cagttactaa acaacaagtg ggtctcggaa atgttgagaa tgttaagcag 1344121 gagacacctg atggtgcgca aaaaaaagct gatactgctt taaaccaatc aaaagattat 1344181 actaacagca cggcctttat tactagacca ttaaattcaa taaccgatgc aaatgattta 1344241 aatcttccgc ctggcactta tcgtttagac actaattaca tgaatgcaaa tccagttttg 1344301 caaaatcaat ttccattaaa tgataacaga acaggtttat taattatcta cccctctgca 1344361 aataaatggg ctacacgtca agattggttt agcatctcta cgaaaacact ttatacaagg 1344421 gtagcagtta atggtactga ttattcaggg tggtatatat tagagaattc ggaaggttca 1344481 caaaataaag cggataaagc tttagctgat gctaaaaact atgttgaaac aaattataca 1344541 aatcaaaagt taactgttct aacaggatca aatgcaatcc aagatgcgag aataagcgga 1344601 aatgattaca aatacggaat cacttttatg gacatagggg ccaataacac tacaggatac 1344661 ccgctcactt atggatttgt aaaaaatgaa aagcatagta attatcgctt tactcagtat 1344721 ttctatggaa atgcagacac aactagtgga agttatgatc atgtagggac ttggatccgc 1344781 cattggtggg cagattcagg ctggactgcg tggcaaaaga tatcagggtt tgctcacgct 1344841 aatattggga ctactgggcg tcaagccctt attaaaggag aaaataacaa aattaaatat 1344901 aaccgtatta taaaagatag ccataaattg tttgatacaa aaaacaatag gtttgtagcc 1344961 agtcatgcag gaatgcattt agtcagtgct agtttatata tagaaaatac tgagcgatac 1345021 tccaattttg aattatatgt ttatgtaaac ggcacaaagt ataaattaat gaatcaattt 1345081 agaatgccta ccccttccaa taacagtgat aatgagttta atgcaactgt tactggatct 1345141 gttacagttc cgcttgatgc aggagattat gttgaaattt atgtttatgt tggttattcc 1345201 ggggatgtaa cacgatatgt tacagattcg aatggagctc tcaattattt tgatgttctg 1345261 gagcttggcg gaagaaatta cccgagagtt taggaggtac ctttatgatc ttatatgatg 1345321 ccattatgta caagtatcca aacgcagtat cgagaaagga ttttgaattg cgtaatgacg 1345381 ggaacggttc atacattgag aaatggaatc tccgggcgcc gttgccgact caggcagaac 1345441 tcgaaacctg gtgggaagag ctgcaaaaaa atccgccgta cgagccgcct gatcaggtgg 1345501 agcttctcgc tcaagaattg tcacaggaaa agctggcacg caagcagctt gaagagctga 1345561 acaaaacatt agggaacgag ttgtcagata taaagctatc attactttcc ttgaaaggag 1345621 attatgctga atgaattatt gggtgcttgc cctctattat gagtgggcga caacggatat 1345681 ggtgaaacag gctttagcat atgaagactg ttcaattcag gatctggcag agggtgtgaa 1345741 caaaaagctg atcacagctg accagtataa agaaattacc ggtaaagcca tgtaaggctt 1345801 ttttattttg cctgttttta gatcaaagga ggatgaagat ggtgaagtat caatatgaat 1345861 ttcctctcga taaggctgga aaagccggcg ctgtaaagcc ctatcgagga ggaaaaaatg 1345921 attttgtgac acctgtttcg aatttgtcag gcgtagcgga gattttaaca aatgctgctt 1345981 taaaggcgac tgaggcatac agtcagctcg ggcaggacag gcttggcgca gttctgattt 1346041 cgaaagtgaa gggctgggcg tatgcagatc gtgaaggtac gctctttata gaagaaagcg 1346101 acaacaacaa tgtttggaca acgacagcag cagttaatgt cgcagcaggc gtcctgacag 1346161 cgacggactg ggtatatctt tctaaacgct attaccgttt ccgctatgtg aacgggaatc 1346221 ttcagcaatc tgagtttgta ttataccaat cagtcggtgc gggtgagatg gatgtgcgtg 1346281 tcaatgaaaa aacgccttta cagattgact ttgcggagaa tcaaacacac gatggacggc 1346341 tgaaagtcga ggctcgcaaa acatttgact ttgtctttca tgaaaatgca gagtccgcca 1346401 gcgagggggc tgctttacct gttgacggtg ccgcgcattt actcgttgaa gtctacggca 1346461 cagcagaaat gagcgaagtc aaattttggg gcaaatcggt gtcaggacag aaactgccga 1346521 tcagaggcgt gaaaactgat gatgctacca ctgcctccag tacattagga aaagctgagg 1346581 catgggcctt tgatattaaa gggtttaagg agatcatcat ggagattatc agtatcaccg 1346641 gcggtactct ttcggtaaaa gggaccgcgg tttcataata gtctcggccc tcggaaggga 1346701 ggtgatctgc atgtgaagga ggagtgagag atgcagcaag aggcagacgt gaatgtgttt 1346761 cagcaggatt tagcagacat gaaaggcgag cacaaagcac ttgagcagag ggtttccgca 1346821 ttagaacgcg tgtctgaccg gcaagaccag caaatcatga cgctgaacga aaaattaaac 1346881 aaaattgaag aaaacaccac gtggattaaa cgcaccatca caggtgccat cattacagca 1346941 gtgtctacag gcatcattgg cggagccatc gccattatgt acagcctgct gcagcattaa 1347001 agggggattt ttatgaacac gtttgacaag ggcacggtca tcaggacggt gcttctttta 1347061 attgctttaa tcaaccagac catgctgatg ctcggcaaat caccattgga cattcaggag 1347121 gagcaggtca atcagctcgc tgacgctctt tattcagccg gttccatcgc atttacaatt 1347181 ggaacgacac ttgccgcttg gtttaaaaac aactatgtaa cagaaaaagg gaaaaaacag 1347241 cgcgacttgt taagggacaa taatctgacg aaataaggag agatgaaaat ggttaacatt 1347301 attcaagact ttattccggt tggcgcaaat aaccgtccag gctacgcaat gacgccgctt 1347361 tacattacgg tgcacaacac agcgaatacc gcagtaggag cagatgctgc agcgcatgcc 1347421 cgctatttga aaaatcctga tacgacgaca agctggcatt ttacagttga tgatacagaa 1347481 atttatcagc atctgccttt aaatgaaaac ggctggcatg cgggagacgg aaatggcagc 1347541 ggcaaccggg cttctattgg aattgaaatt tgcgaaaatg ccgatggcga ttttgcaaaa 1347601 gcaacagcaa atgcccagtg gctcatcaaa acattaatgg ctgaacataa tatcagtctc 1347661 gccaatgtcg tccctcataa gtattggtca gggaaggaat gtccgcgaaa attgttagat 1347721 acgtgggatt cgttcaaagc aggaattggg ggaggcggca gccaaactta cgtcgtgaaa 1347781 cagggcgaca cacttacatc tatagcgaga gcatttggtg ttacggttgc tcagctgcaa 1347841 gagtggaaca atatcgaaga cccgaatctt attcgcgttg gtcaagtatt aattgtaagt 1347901 gctccatcgg ctgctgaaaa acccgagctc tatccgctcc ctgatggtat cattcaattg 1347961 acaacacctt atacatcagg agaacacgtc tttcaggtgc aacgagcact tgcggctctg 1348021 tatttttacc ctgataaagg cgctgttaac aacggaattg acggcgttta cggaccgaaa 1348081 acagctgacg cagttgcccg ttttcagtct gttaacggtc taactgctga cggtatctac 1348141 gggcctgcga cgaaagagaa gatcgcagcg caattaagct gatcaaagac cataaaaatc 1348201 ccggagccgc tccgggattt attttttctt cttcaacttt tttataattc cagcactgcg 1348261 ctccctcacc cgaagcgagt acccggaaag cccaaacctt ccgtaatcaa caaacttcac 1348321 acgcctcacc aattttttca ctgtatcacc tgacattatc ctctgtttgt atttattata 1348381 tgtcaccctt taagaaaagg aataaggaca agagctgttt tcccttgtcc ttttagtgtg 1348441 atcatgcttt ttttcgttta tactcgtcaa tcagccgttc gttttctttg aagattcttg 1348501 ctgtatgcgg actgacttga tagcttgcga cactggtggt tgaacgtttt ttcaggattt 1348561 taaacggctt cgccgctctg ggctcgcatc tgttttgaaa cgcacgttcc attatccttc 1348621 accttcctcc tcaattggca gcaccaaatc atatatgctc gttaatgacg taaatagcaa 1348681 ataatcaaat tccgtgacaa tgctgtcaga cgtcagcttg atgacatagt tctgtgtctc 1348741 gatggtaaaa gggatgagaa ccacttttcc gtattggtcg taataaacat cctttcgatc 1348801 gagccgtgtt tgtacatctg ccggatcatc catatgctcg gttaaccggt ctttatcagc 1348861 ctgtgtcgaa tagtggcaaa gagaagccgt taagttcatt ttatcagcat aggttttcag 1348921 cagcttatca ataccttcag cataagcatc tatacttcca taataaacat ggatcggttc 1348981 gtttttcaat aggtattggt atgttttcag ccgattgaga tacatgtgga gcatttcgtt 1349041 gttttcttca agaatttctc ttgtgtctgt ttcaagctcg ctgccggcca gttttttgac 1349101 atatgcactt aagaagataa aagcatcaat caaagcaaaa ctgactgcga caatgagata 1349161 ccgttcccag tgggtaaata gggaagtggg ctcatatgtc cagtatacca tagcgcccag 1349221 aacaaacagc aaataccaag ttttccgaat ggcggacatt ttttctttga ccttcgcttc 1349281 gaaacgccac gtggcataca cgtataaccc cagtccggcc acgatgcacc agaccatgat 1349341 ctgaaagaat aaaaccatat tcgaatccct cacatctgaa ataggttctg cttattgtat 1349401 tcgagagatc cggatggttt tcctgttcca tcaaaaaaac cgctcctttg acagaagcgg 1349461 tgtgacatta aaatatcata tttaaaataa agtaggcgat ggcaccaagt gtcgctgaaa 1349521 tcggaagcgt gatgacccat gtaatgagca ttcgcttggc cgtaccccag tttacgcctt 1349581 ttacgcggtg ggacgcaccg acgccaagaa ttgatgaaga aatgacgtgg gttgtactga 1349641 ccggcaaatg aataaacgtg gcgccgaaaa taatggctgc tccggttaag tcagcggaaa 1349701 caccgtttac cggacggatt ttcatgatct ttccgccaac ggttttgatg attttccagc 1349761 cgccgattga tgttccgaga cccatggctg tcgcgcaggc gaattgcacc caggtaggaa 1349821 tatcattagc agaagtatgt aaattcgctg tgatgagagc cattgtgata attcccattg 1349881 ctttttgcgc atcgtttgtt ccgtgtgtat acgattgcag ggcagctgtt acaatctgca 1349941 ctctgcggaa ttgcttattc gttttcgcca agttgctgtc tttgaaaatc agcttaacga 1350001 tgctataaag aataaaacca aggacaaagg caataattgg tgatagaatc agtgcttcaa 1350061 tgattttaat gaagccctta tagtttaacg ctgcaaatcc ggctgccgca atggctgcac 1350121 cggcaatagc gccgatgatg gcatgggatg agctgcttgg gataccgtag taccatgtga 1350181 taaggttcca ggcaattgca gcgagtagcg cagccaaaat gacaacagag ccattttcca 1350241 gcgtataagg atctacgatg tctttcgtaa tggttttggc aacacctgta aacgtcattg 1350301 ctccgacaaa gttcatcaca gcagccaata taatggcatg gcgcggtttt aacgcttttg 1350361 ttgataccga agtcgcaatt gcgtttgccg tatcatgaaa cccgttgatg aaatcaaacg 1350421 ccagagcaca aatgactatt agtatcgtta atattaatag aatatccatt tttacccctc 1350481 gttacgcgtt tttcataatg atggtttcaa gattattggc aacactttga caagagtcgg 1350541 cgatttcttc aagcgtttcg tatatttcac gatattgaat gactttgatt ggatctgttt 1350601 catttccgaa aagattcttt aatgattttc tgtgcaagtt gtcacaactg tgctcatact 1350661 ctttaatttt gattgcgtga ggctgaatat cctttaagcg attttctgcc agcagctcga 1350721 tcgtaatcaa aatctctttc gcacattctc tgatatatcc gctgaattta tcaatatgct 1350781 cgtctgatga agtaattgag aaaatctcca tcatggcaga gaaatgttcg attccgtcaa 1350841 gcacatcatc caagctgttt gtcagctgaa ggatatcttc gcgctcaata ggagtgatga 1350901 acgctttgtt aagctcttta atcatgacat gaacatgatt gtcacctttt gtttcatatt 1350961 cctttaacgt atctgcaaat tctttaagag tcgtttggtt agtgacctta aaattcacaa 1351021 aatattctgc agtttcgtct atgttctttg caatttctgt taaaaggagt gagaacttat 1351081 ctttttttct tcttatcatt aaaaaccctc catagtttga atgaacaatg cacacatcaa 1351141 attattatat agccttttgt cgaaaaaaaa caggtaaagt cgaaaaaaac gtatcttgac 1351201 ttttttgata aatcgtgtct ccttattttg acctacttcg ctttaaaaaa acgacccaag 1351261 tttgcaaaaa ctttctgctt aacgtaaaaa gtatatcaaa agttgtgttt ttcctgtcaa 1351321 cttttatctt ctgtttcacc aaaaaacggt tccctaaaca agggaaccgt tttatcagct 1351381 tgcttttcgt tttttcatcc cgtaataaac aggcagtccg gcaaggccga tgaggatgga 1351441 taatccgcag ctcattgtat ctgtaatgag tgtgctgcct aacacaaaga aggagcccgc 1351501 gattgccaga attggcataa atggataaag cggaacactg taggcgcgct tttctccctt 1351561 tgctcgcttg cggagaataa acactgcaaa aaaggccatc acataaaaaa tgtagatcat 1351621 gaaaatggag atttctgaga gcttatcagg gttgctgatc agcatcataa tcaaagccaa 1351681 agcaatttga aaagaaatcg caatccatgg tgtgcggaac gacgggtgta catgtgacag 1351741 tttttcagca aatggaagct gtttgcgttc cgccattgca aatgaaacac gcgggaaaga 1351801 aagcaccttt ccatttaagc acccaaagat gctgacgata atccctacac tgatcagctt 1351861 tccgccaatt gaaccgaaca gcatggttgc agcggtgctt gtcgcatttt caccaagcgt 1351921 gacaatttcg ttcgctgaca ggatgtgaag caatgcaaaa ttaatgaaaa tatagatcgc 1351981 cgttacaatt aataatccgc ccgtcatagc gcgtggcagc agcttttcgg gatttttcat 1352041 ttctccgccg agagcggcaa ggagaatcca tccgtcataa gcaaacaacg tagctaaaat 1352101 agccgccccg aagttcatat cagaaatgct ttcgtttact gctgtgaaga tgtgctgatc 1352161 gcctttccaa aggccaaaga cgatgatgca ggcaatcgga atcagttttc cgatcgttgt 1352221 cagcgtttgg acaaaaccgc cgtattttgt accgataata ttaatgacgc ataaaaagag 1352281 aactgctata attccaatga cttttgatag tccagatccc cagccgaaaa gattcgccat 1352341 taaagatcca aaatataaac ccagcgcgcc aataatcgcc gggccgtaaa tgataatctg 1352401 cacccagccg cacaaaaatc cccaaaactc gccgtacact tcttcaaggt acgtataaag 1352461 cccgccggtt tttggaatct gcgttccgat ttccgcgatt gtcaaaccgc ccgccagtgt 1352521 taaaataccg cctaacagcc aggcgaaaag cgccattttt gaatcacctg aataagcaag 1352581 cacagcgccg ggcttcataa aaacaccaga accgataatg gttccgatga caagagtaag 1352641 ggcaaacaag aggcctatct cttttttcaa accgttgtct tcagtatgca tgtccttaac 1352701 ctcctatgat gttgaagctt catgttgaag aatctatttt ttcatattgt aaaccctatt 1352761 ttagaaaagt gaaataaaat aaattttctg attttcgaaa tttgctttgt gtacagcaga 1352821 taaaactgta gaaatacctg ttttaatggt ctataaacga ataaaattca taatttttat 1352881 ttacaaagtt cgtgttttat gtattaggat tttagccggt acagagggga gatgagaatt 1352941 cagaaaatga acgaaccttc ggtgaagctg atatgttgac tttctcatgc gaataaaata 1353001 ctttgttatt agaacaataa atatacaatt atgatatgat atctcgaaat cgagataaaa 1353061 taacctggag ggacagcata tgaaagttaa cggcattcac cacgtatcgg cattaacggc 1353121 cgacgcacaa aaaaacttgg atttctataa gaaagtatta ggattaaagc tcgtcaaaaa 1353181 atccgtcaat caggatgaac cgacaatgta ccatctgttc tacggagatg aagtggcaaa 1353241 cccgggaact gagctgacgt ttttcgagat tccccgcatt gcaccgtttc atgcgggaac 1353301 aaacagtatt tcttctattg gattgcgcgt tccaggcaca gaagccctgc attactggaa 1353361 agaacgtttt gaagagcagc aagtaacgca cagcggcatc tccaaaagag ccggacgtga 1353421 catattggca tttcaagatc atgaggggca gcgacttgtg ctgactgctg atgaggaagg 1353481 aaaaggatat ggcctgcctg ttaaacagag cggcattccg gaagaatttt cgtttcgcgg 1353541 gttagggccg gttgaactga ctgtgccata tgctgaacca actttacacg tattgacgaa 1353601 tattcttgga tttacagaaa tcagccgtga accagtcgaa gggcaaggaa ccgccgttat 1353661 tctggaatca ggagaaggcg gtgctgcaac ggaaatccat ttaatagaaa gaaacgatct 1353721 tccgcgagag cgtcaaggca aagggagtgt tcaccacgtc gcatttcggg taagagatga 1353781 agaagaactt gccgggtggc accggatcat cagccgcgaa ggctttagca attcaggcat 1353841 agttgagcgc tactatttca aggcgctgta tttcagagaa ccgaacggca ttttgttcga 1353901 gttatcaaca gacggaccgg gctttatggt agatgaaaat cttgatgagc ttggccaaac 1353961 gattgctctt ccgccatatc tagagcatcg aagagcagaa attgaagcaa aattgaaacc 1354021 gatccaataa attgtgattc ttttgccttc cggcgccgcc ggagggcttt ttttattacc 1354081 ataattaatt ttgacctaaa cagcatgcct tattagggag gaaatatcag atgctgattg 1354141 ggagaaatgg cttaaaaccc tttgcaaata tgggtgattg gtatggaatg gcctcggcaa 1354201 aaatattgtc tttgtttatt aatagtttat tcatatttgc ttgttacact atttcaaagt 1354261 tagacaaaaa ggagtgaaaa ataagtggaa aagaaaaaac gcgagctgga tatcgtcctc 1354321 ctcctcattt tgctcgcatc tgcattctta aatatctata acatttggaa ggacgacacg 1354381 gtgaatcctt attacaccgc ggcagttaca agtatgatgc aaagctttca taatttcttt 1354441 tatgcttcgt tcgatgctgc cggctttata acagtagata aaccgcctgt tacataccaa 1354501 atccaaacga tcagcgcact gatattcggt atgcacggct ggagcgtcat cctgcctcag 1354561 gcacttgctg gtgtaggttc tgtccttctt atgtacttgc tgataaagcc gacatttgga 1354621 aaaacggcgg cgcgtattgc ctcatttgtt atggcatgta cgccgatagc tgtagctgta 1354681 gcacgtacaa acaatgttga tgcattactg gtatttttct tattgcttgc tacatggctt 1354741 ctctttaaag cgatcagaaa aggaaagctg atctggctgt tagcagcatt tttcgttgtt 1354801 ggagtaggtt ttaatacaaa aatgctgcag gcttacatga ttttaccggc tttcttattg 1354861 ttctatctga ttgcggcaaa cgccacaatc aagaaaaaaa tcgtttcatt ggtaagtgcg 1354921 ttagccgtat tagcagccgt ttcgttatcg tggccgctca ttgttgacaa tatccctgca 1354981 agcaagcggc cttatatcgg aagcagccaa accaactctg ttttggaatt ggctttcggc 1355041 tataacggaa tccagcggct gacaggccaa aattcaggcg gcggccaggg tgcgccaaac 1355101 aaagacgctt caaaagaaat gtcttcttct gataacactc aagcaccgcc taatcagtca 1355161 tcaagcaaca gctcatcaag cgatggtaaa tcctcaaatg gcaatatggc ggcgcctcca 1355221 tccaatggcc aaatgccaag cggcggtcaa ggaggccctc caagcggcgg agatggcggc 1355281 caaggcggac ccggcggaga cggagggaaa ggcggtacag gaaccggttc gaaaatgcaa 1355341 tcaggttcag ggatgtttgg aacgggaaca cctggtccac tgcggctttt ccaacaagag 1355401 ttatctgatc aaatcagctg gcttctgcca tttgcgatat ttggaatcgc aggcttactg 1355461 atcgctggcg caagagaaag aagaagatta tctgtagagc agaaggaaac ggtgttctgg 1355521 gttgcgtggc ttgtaccgat tgccggattc ttcagtgtcg cagaattttt ccatcattat 1355581 tatctcatca tgctggcacc gccgattgcg gctcttgtcg gtgcggggtg ggtcgctctt 1355641 gttcatctgt accgcaatca gacaggctgg aaagcatggc ttttgccggg agcaattatt 1355701 gcgacaactg gatttgaatt gtttattctc agaaactaca acgatcaaat cggtgttgga 1355761 tggagtatcg gggtaggtgt tatcggcgtg ttgtcagcga ttgctttgct gctgtttaaa 1355821 cagcgccaaa aaccgttcag ttattatgtt tcacttgcag ctctcctcgc attgctggtg 1355881 atgccgatgt attgggcaag tacaccgctt ctgtacggag gcaacagctc actgcctgaa 1355941 acaggccctc aactcgcatc aatgagcgga aaaggcatgg gaatgtctga tgcgactgta 1356001 aatgaaaaac tgatcaaata tctagaggag aataactccg gagctgaata cctattcgcc 1356061 acaaccgatt cgaacacagc ggcaccatat atcattaaaa cgaaaaaagc tgtcatggct 1356121 attggtggat acagcggttc tgacccggca atcacactga ctcaattcaa aaaacttgta 1356181 aaagaaggaa aagtgaaata cttcttggct tctggaatgg gaagaggcgg aaacaatgac 1356241 attgttgaat gggttgagaa aaatggaaaa gaagtagcat cagaaaaatg gcaatcaagt 1356301 tctgatcaaa aaacagaaaa tactgattca gctgatacat caagcagcaa ggcttcaggt 1356361 gaaaacggca aaatgggcgg acctggcgga atgaatcagt cagcaacatt atacgaacta 1356421 catgctgatg aataggaggc aaaaacatga gcagacatat tcaatattca attgttgtac 1356481 ctgtgtataa tgaagagctt gtcattcatg aaacctatca gcgcttaaaa gaggtcatgg 1356541 atcaaacgaa ggaaaactac gagctgcttt ttgtcaacga tggcagcaaa gaccgcagta 1356601 ttgagatttt aagagagcac agcctgatcg atccgagagt gaaaattatt gatttttcaa 1356661 ggaattttgg acatcagatc gccattacgg caggtatgga ttatgcacag gggaatgcaa 1356721 tcgtcgtcat tgacgccgat ttgcaggacc ctcctgaact gattttagaa atgattgaaa 1356781 agtggaagga aggctatgaa gtcgtgtacg ccgtacggac taaacgaaaa ggggaaacct 1356841 ttttcaaaaa acaaaccgcg gctatgtttt accggcttct cagcggtatg acagatattg 1356901 atatcccgat tgatacgggg gattttcgcc tcatggacag aaaagtctgt gatgaaatga 1356961 agagattaaa agaaaaaaat ccatttgtaa gagggctagt cagctgggtg ggtttcaaac 1357021 agacagcggt cgagtatgta cgtgatgaaa ggctcgccgg agaaacaaag tacccgctca 1357081 agaaaatgct gaagctgtca atggacggca tcacgacatt ttcacataaa ccgctgaagc 1357141 tggcaagcta tgcggggatt ttaatgtcag gtactggatt tctgtatatg tttatcgtgc 1357201 tgtatctgaa gctattcaca gacagcacga ttaccggctg gtcatcactt attgtgatcc 1357261 agctcctgtt cagcggcatt gtccttctga ttttgggcgt gattggcgaa tatatcggca 1357321 gaatctacga tgaagccaaa gacaggccgc tttacatcgt ccaaaaatcg tatggaattg 1357381 aaaataaaag actctataga gaccagcata tgtcataacc tcaaaccccc tgtccgtaat 1357441 ggacaggggg tttttatgct ctgagcacga tctaaagcaa aagatgctga tagatatatg 1357501 gaaattgggt aaagaagaga ttgtgagctt gtactgcggt tcagtcatgc tgaaataaaa 1357561 acagcaaaac ttaaagattt cgtcctcggc tttgctgcat gtcagctgtt atattggggg 1357621 gcttttaaga aacgcatgat tagagccgta ccagttatgt ttaatagaat actcgtaccc 1357681 aatacaattc cccacgtcaa cgtcgattca gagagaagaa agctcagcaa aagaaaagcc 1357741 aatcctgcgc agatcatacc cagtcccacg gttttcatgt tcatgcctcc tagcaaacga 1357801 tgtttctagc atctgatgtg aatgatgtca atctgtatga tatacggata tctcgtcaga 1357861 aagtttcata gaacaattag gtcttttatc taataaaaag cctcagaccg cttttacggc 1357921 ctgaggcatt atgtcttacg aagttttctc ttctttttga tccagtttaa tttttttcgt 1357981 catttctttg ccgtttcgga gaattttcac ttcaacggta tcaccgatct ttgcgtcttt 1358041 atataagata ttgcgcaatt cactgcctgt atcaatttct ttacctttta ggccgatgat 1358101 aatatcctcc gcttttaatc cggccttttc agcaggagag cctgaagcga cctcacggat 1358161 gtaaacgcct ttattcagct ggctgccgaa caggccgagt gtgccttctt ggtaattttg 1358221 cggcacttgc tctagatcaa gcatgctgac accgatatat ggacgttcaa tttgtccttt 1358281 agacagcaat tcttcagcaa tcggttttac gtcattgctt ggaatggcga atccgatacc 1358341 ctcaacatca tcctcactga ttttcatact gttaatgccg acaattttgc cgtctgtatt 1358401 taacaaagga ccgccgctgt tacctggatt aattgctgcg tctgtctgaa tgacgttaat 1358461 gctcgtttcg ccggctgatg tagacattga aaccgttctg tccacgccgc ttacaattcc 1358521 ttgtgttact gtgcgggaca ggtcttttcc aagcggatcc ccaatcgcaa taacggtctc 1358581 gcctgttcta agatcagatg aatcaccgaa gtttgccact tttgtgacgt ggtcatcact 1358641 gatttggagg acggctaaat cagttaacga gtcactgcct accagctttg cagtaacctc 1358701 agtgccgtca tataaagata ccttcagtga tgatgcccct tctacgacgt ggttatttgt 1358761 aatgatataa gccttgccat tctctttttt gaaaatgaca cctgaccctg aaccgctttc 1358821 tgtatcttcg ctggaatcag aagaactaga gccgaacaaa gagctgtttg attgtgcctg 1358881 aagatttgta ataccgacaa tcgctggtga aaggtcttct accatatctg agattttaga 1358941 agagtcctcg ctcttgaatg cagatgagct gcttgagctt tttttagatt cagaggaggt 1359001 gcttgttgct gtaacagatt gcgtttgctg ctggctggat gattgttttg cagtgtcctg 1359061 agaatcatgg tcaccaagcg gtgtaaacgt gtaaatgcca agagcaagac tgccgccgat 1359121 cactccgcca agcaacggtc tgaaccatcc gaatcctcgt tttttcttct cctgatcatg 1359181 aatgacattg cgggccgagt aggaggcgct ctgatcgttc tctttcgtta aaaagacctc 1359241 attctcatta cctttcgttc tgttttcatc acgatagtta tccatcatgt tcactccgtt 1359301 tctctatttt cacatgtcta tttatattga taggtttatg acttgagttt atcataaaca 1359361 aaaactgtgg gataaaaatg aaaagattat gggaaattgt gaaaaagtgc ggaaaacggt 1359421 acacttcata ttgtatatga aaggactgag tcgatggaac agattggatt gattggatat 1359481 ggcagcatgg cggatatgat cgctagacag ctgttgaaac atgaacaaat aaaagagaat 1359541 gagctattta ttgagacgag aacgaagggg gagcggctgc gggcactcat gtcagattat 1359601 ccaaacgtat cggctgatcc gttggagaat tgggcaaata cgtgccaatt gattttgata 1359661 tgcgtcccgc cactccatgt catcgaaaca atgcgccgtc tgtacccgta tgtgaacaga 1359721 aatactcaca tcgtatccat agctgccggt gtgccgctgc gtcttttgga ggcagaaaca 1359781 gaagccggta tctcacgtgt tattcctgcc attacgtccg aagcagaagc cggcatctca 1359841 cttgtcgttc acagtgaagc actggctgca gagaaaaaag aacgtctgaa tgaattgtta 1359901 tcggttttca gccgtgtacg ggaaatcaaa gaatcgaatt tagatgtggc cagcaattta 1359961 acgagctcgg caccgggatt catagctgca atctttgaag aactggcact gtctgccgtc 1360021 agaaacagca gcctgtccaa agaagaagcc tttgattttc tgattcattc gctatacgga 1360081 actggcaaga tgctgatcga aaaaaatatg tctttcgagg agacgctgga acgtgttgca 1360141 accaaaggcg gaataacggg agagggagct gaggtgatac acgcctctgt gccggacgtt 1360201 tttgatgagg tatttgaaag aaccctgaga aaatatgaac tgcttacaga acaggttggt 1360261 aaacaaacat gaatccttga aagaggattc tttttttatc actgaatgat tgagattttt 1360321 cccagttata ttgcattttt cctctttttt taatataatt tgttagaata ttcataattt 1360381 agtaaaaaag gaggagcgtt atgaaattgt acatgtcagt agatatggaa ggtatttcgg 1360441 gtcttccgga cgataccttt gtggattccg gcaagcggaa ttatgaacgc ggacggctta 1360501 tcatgactga agaagcaaac tactgtattg ctgaagcgtt taacagcggg tgtaccgagg 1360561 tgctggtcaa tgacagtcat tcgaagatga ataatctgat ggttgaaaag cttcaccctg 1360621 aagcagactt gatttctggt gacgtcaaac cattttcaat ggtggaggga ctggatgata 1360681 cgtttagagg cgctttgttt ctcggttatc atgcgagagc ctcgactcct ggtgtcatgt 1360741 cacacagcat gattttcggc gtccgtcatt tttacataaa cgatcggcct gtcggtgagc 1360801 ttggattaaa tgcatacgtt gccggttatt atgatgtccc ggtattaatg gtagccgggg 1360861 atgaccgggc ggcgaaggaa gcagaagagc ttatcccgaa cgtgacgaca gccgcagtca 1360921 aacaaaccat ttcaagatcc gcagtgaagt gcttgtcgcc tgcgaaagcc ggacggctgt 1360981 tgacagaaaa aaccgcattt gccctgcaaa acaaggacaa agtcaagccg ctcacaccgc 1361041 ctgacaggcc agttctgagc attgaattcg ccaattatgg ccaagcagaa tgggcgaatc 1361101 tgatgccggg aacggaaatc aagacgggaa ctacaaccgt tcaatttcag gcgaaggaca 1361161 tgcttgaagc ctatcaggcg atgcttgtca tgactgagct tgcgatgcgg acatcattct 1361221 gctaaagggg tgttttaggc tttggcgcga tacatgataa agcgtttttg ggcaatggca 1361281 gctacgattt tggtgattac caccctgact tttgttctca tgaaggtcat tcccggatct 1361341 ccttttaacg aggagagagg cacaaatgaa gccgttcaaa aaaatctcga agcctactat 1361401 cacttagacg atcctctcat tttccaatac attttctact taaaatccat cattacattc 1361461 gatttcggac cttcaattaa aaaaccgtcg gacagcgtaa atgatatgct ggaacgcgga 1361521 tttcccgttt cctttgagct tgggatgaca gcgattgtca ttgctgtgat ttctgggctg 1361581 gtgctgggcg taatcgctgc actccgccgc aatggctttt tggactacgc cgcgatgagt 1361641 cttgcagtac tcggcatctc catcccgaat tttattctgg caacattgct cattcagcaa 1361701 tttgctgtca atctcaaact atttcccgct gcgacatgga cgagcccgat tcatatggtg 1361761 cttccgaccg cagcgcttgc tgtagggcca atggcgatca ttgccaggct gacacggtcg 1361821 agcatggtcg aagttctgac acaggattat atccgcacag caaaagcaaa agggctttct 1361881 ccgttcaaaa ttatcgtaaa acacgcactc agaaatgcac tcatgcccgt cattaccgtc 1361941 ctgggcacac tcgtcgccag catcttaaca ggaagctttg tcattgaaaa aatctttgcc 1362001 attccgggaa tgggaaaata ttttgttgaa agcattaatc agcgggacta ccccgtgatt 1362061 atgggaacga ccgtttttta cagcgtcatt ctgattatca tgctgttttt ggtcgatttg 1362121 gcctacggtc tcttagaccc gcgcattaaa ctgcataaga aagggtgaag cgtgtgaatc 1362181 tccctgtaca aacggatgaa cgccagccag aacagcacaa tcaggtgcct gatgagtggt 1362241 ttgtcttgaa tcaggaaaaa aatcgggaag ccgattcggt caagcggccg agtttgtcat 1362301 acacgcagga tgcctggagg aggctgaaaa aaaataaatt agcgatggcc ggactcttta 1362361 ttcttttatt tctttttgtc atggcagtta tcgggccctt tttatcgccc catagtgtcg 1362421 tacgccaatc gctgacagaa caaaatcttc cgccctcagc cgatcattgg ttcggcaccg 1362481 atgaactcgg ccgggatgtg tttacccgaa catggtatgg cgcgagaatc tcgttgtttg 1362541 tcggcgtgat ggcagcactg attgattttt tgatcggtgt catttacgga ggcgttgccg 1362601 gctataaagg cggcaggatt gacagcatta tgatgcggat tatcgaagtg ctgtacggac 1362661 tgccgtatct gcttgttgtc attttgctga tggtgctcat gggaccggga ctgggcacga 1362721 ttattgtggc gctgactgtg accgggtggg tcggcatggc gagaattgta agaggccagg 1362781 tgcttcagat taaaaattat gaatatgtac tcgcctcgaa aacctttggc gcgaaaacct 1362841 ttcgcatcat ccggaagaat ttgctgccga atactatggg agcgatcatc gtacaaatga 1362901 cattaaccgt acctgccgcc atattcgcag aatcattttt aagctttctc ggcctgggca 1362961 tacaggctcc gtttgcaagt tggggcgtga tggcgaatga cggcctgcct acgattttat 1363021 ctgggcattg gtggcgcctg ttttttccgg cctttttcat atctctgacg atgtacgcgt 1363081 ttaatgtgct gggggacgga ttgcaggatg cgcttgaccc taagctgagg aggtagctgt 1363141 atggaaaaag ttctgtcagt ccaaaatctg cacgtgtctt ttacgactta cggcgggacg 1363201 gttcaggcgg tcagaggggt gagctttgat ttgtataaag gagaaacctt tgcgatcgtc 1363261 ggcgaatccg gctgcggcaa aagcgttacc tcccaaagca tcatgggcct gcttccgcct 1363321 tattcggcga aggtgacaga cggcaggatt ctatttaaaa acaaagacct ttgccgtctc 1363381 tctgacaaag aaatgagagg tataagggga gccgacattt ctatgatttt tcaagacccg 1363441 atgacggcgt taaaccctac gctgactgtc ggcgaccagc tgggggaagc gctattgcgc 1363501 cacaaaaaaa tgagcaaaaa agcggcacgg aaagaggtgc tttccatgct gtcattggtt 1363561 ggtattccag atcccggaga gcgcctaaag caatatcccc accaattcag cggcggtatg 1363621 agacagcgga ttgtcattgc gatggcgctg atttgcgagc ctgatatctt aattgcggat 1363681 gaaccgacca ccgccctgga tgtaaccatt caggcacaga ttttagagct gtttaaagag 1363741 attcagagaa aaacggatgt gtctgtcatt ctgattacgc acgatttagg ggttgttgcc 1363801 caggtagctg acagagtcgc agtcatgtat gccgggaaaa tggcggaaat cggcacaaga 1363861 aaagatattt tttatcagcc gcagcaccca tatacaaaag gcctgctggg ctctgtcccg 1363921 cggctggatt taaatggcgc tgagctgacc ccgattgacg gaacgccgcc ggatttattt 1363981 tcgcctccgc cgggctgccc gtttgccgcc cgctgtccga acaggatggt tgtgtgtgac 1364041 agggtgtacc cgggccagac gatcagatct gactcgcaca ccgtcaactg ctggctgcag 1364101 gatcaacgag cagagcatgc ggtgctgtca ggagatgcga aggattgaac atgaaaaggg 1364161 ggaagaggat gaaacgagtg aaaaagctat ggggcatggg tcttgcatta ggactttcgt 1364221 ttgcgctgat ggggtgcaca gcaaatgaac aggccggaaa agaaggcagt catgataagg 1364281 caaaaaccag cggagaaaag gtgctgtatg taaataatga aaatgaaccg acttcattcg 1364341 atccgccgat cggctttaat aatgtgtcat ggcagccgtt aaataacatc atggaggggc 1364401 tgacgcgtct tggcaaagat catgagcccg agccggcaat ggcggagaaa tggtctgttt 1364461 cgaaagataa taaaacttac acatttacga ttcgggaaaa tgcgaaatgg acaaacggag 1364521 atcctgtaac agccggagac ttcgaatacg cgtggaagcg gatgcttgat ccgaaaaaag 1364581 gcgcttcatc ggcattccta ggttatttta ttgaaggcgg cgaagcatat aacagcggga 1364641 aagggaaaaa agacgatgtg aaggtgacgg caaaggatga tcgaaccctt gaagttacac 1364701 tggaagcacc gcaaaaatat ttcctgagcg ttgtgtccaa tcccgcgtat ttcccggtaa 1364761 atgaaaaggt cgataaagac aatccaaagt ggtttgctga gtcggataca tttgtcggaa 1364821 acggcccgtt taagctgacg gaatggaagc atgatgacag catcacaatg gagaaaagcg 1364881 acacgtattg ggataaggat acagtgaagc ttgataaggt gaaatgggcg atggtcagtg 1364941 acagaaatac agattaccag atgtttcaat caggggaact tgataccgct tatgtccctg 1365001 ctgagctgag tgatcagctg cttgatcagg ataacgtcaa tattgttgac caggcgggtc 1365061 tctatttcta tcgatttaat gtcaacatgg agccgttcca aaatgaaaac atcagaaaag 1365121 cctttgcgat ggctgtggat caagaggaaa ttgtaaagta cgtcacgaaa aataatgaaa 1365181 aaccggcgca cgcctttgta tcgcctgggt ttacgcagcc tgacggcaaa gatttccgtg 1365241 aagcaggcgg agacctgatc aagcctaacg aaagcaaagc gaagcagctg ctcgaaaagg 1365301 gcatgaagga agaaaactat aataagcttc ctgcgatcac gcttacttac agcacaaagc 1365361 cggagcataa aaagattgcc gaagctattc agcaaaaatt gaaaaatagc cttggagtcg 1365421 atgtgaagct ggccaatatg gaatggaacg tatttttaga ggatcaaaaa gcgctgaaat 1365481 tccaattctc tcaaagctca tttttgcctg attatgcaga ccctatcagt tttctggaag 1365541 cctttcaaac gggaaattcg atgaaccgca caggctgggc caataaagaa tacgatcagc 1365601 tgatcaaaca ggcgaaaaac gaagccgatg aaaaaacacg gttctctctt atgcatcaag 1365661 ctgaagagct gctcatcaat gaagcgccga tcattccggt ttatttttat aatcaggttc 1365721 acctgcaaaa tgaacaagta aaaggaattg tccgtcaccc tgtcggctat atcgatttaa 1365781 aatgggcaga taaaaactga tggaggcgat tgaggaaata ctgcttcttt atgcgaagga 1365841 gcggtatttt ttctctttct tgcacgtata cgtagggtgc agagcaaatg aaaggagtgt 1365901 tttcgttgaa ttacaagccg aaagcgttga acaagggtga tacagtcgga gtgatcgcgc 1365961 ccgcaagtcc gccggatcca aaaaagcttg acaccgcgct tttattttta gaagagctcg 1366021 gtcttcaggt gaagttgggc aaggcgctga aaaaccagca cggctattta gcgggacagg 1366081 atgatgagcg gctggcggat ctccatgaga tgttcagaga cgatgaggta aaagcagtgt 1366141 tgtgcgcatg cgggggtttt gggacaggac gtatcgccgc gggcattgat ttcagcttga 1366201 tccgcaaaca ccctaaaatc ttttggggat acagcgatat tacgttttta catactgcca 1366261 ttcatcaaaa cacaggtctt gtcactttcc atggcccgat gctcagcacg gatattggcc 1366321 ttgacgacgt tcacccgctg acaaaagcgt catataagca gctcttccag gagacggaat 1366381 tcacctatac agaagagctt tctccgctga ccgagcttgt tcctggaaaa gcggaaggcg 1366441 agcttgtcgg gggaaatctg tctttgctga cgtctacact gggcacgcca tttgaaattg 1366501 atacgagagg aaagcttctg tttattgaag atattgacga ggagccttat caaatcgacc 1366561 ggatgctgaa tcagctgaaa atggggggga agctgacgga cgcggcggga attctagttt 1366621 gtgattttca caattgtgtc ccggtgaagc gagagaagtc tctctcgctt gagcaggtgc 1366681 tggaagacta tattatttct gcgggcaggc ctgctctgag aggatttaaa atcggccact 1366741 gctcgccaag tattgccgtt ccgatcggtg cgaaagctgc tatgaataca gcagaaaaaa 1366801 cagccgtaat agaggcgggc gtttcagaag gggcgctgaa gacatgaaaa tcattcgaat 1366861 cgaaacaagc cgaatcgctg tcccgctgac aaagccgttt aaaaccgcac ttcgcactgt 1366921 gtatacggct gaatcagtca tagtaaggat tacttatgac agcggtgcag tcggatgggg 1366981 agaagcaccc ccgacgttag tgattacagg agacagcatg gatagcattg aaagtgccat 1367041 ccaccatgtg ttgaagccgg cattgcttgg aaaaagcctg gcgggctatg aggccattct 1367101 gcacgacatc cagcatcttc ttacaggaaa tatgagcgcg aaggctgctg tagaaatggc 1367161 tctatacgac ggctgggcgc agatgtgcgg gctgccgctt tatcaaatgc ttggcggata 1367221 tcgagatacg ctggaaacag attatactgt cagtgtcaac tcacctgaag agatggcagc 1367281 tgatgccgag aattatctca aacaaggctt tcaaacgctg aaaataaagg tcggaaaaga 1367341 tgatattgca acagatatcg cccgtatcca ggaaatcaga aaacgtgtcg gatcagctgt 1367401 gaaactgcgt ttagacgcta atcaggggtg gaggccgaag gaagcggtaa ctgccattcg 1367461 gaaaatggag gatgcgggcc taggcattga gcttgtcgag cagcctgtcc ataaagatga 1367521 tctcgctggg cttaaaaagg tgacagatgc aacagatacg ccgattatgg ctgatgaaag 1367581 tgtttttaca ccgcgccagg cgttcgaagt tctgcaaacc cggagcgcag acttgatcaa 1367641 tattaaattg atgaaagcgg gcggcatcag cggagcagag aaaattaatg ccatggcgga 1367701 ggcctgcggg gtggagtgta tggtcggcag catgatcgaa acgaagctgg gcattacggc 1367761 cgcggcgcat tttgcggcaa gcaagagaaa catcacacgc tttgattttg acgcgccgct 1367821 gatgctgaaa acagatgtat tcaatggcgg cataacatat agcggcagca cgatttcgat 1367881 gcctggcaaa ccgggcctcg gaatcatcgg ggctgcgctt ttgaaagggg aaaaagagca 1367941 atgatgcaca ctgtcatatc agcagtggcc aacatctgga cagcgcctga ttcacctcgt 1368001 ccgtctgatc aattcatgct tcaaccgact gtaatgatca gagactggct ggagcgcatg 1368061 acgtatgatg aacggcttgg attatgtaca gacaatgtaa tccaaactca ggttctcttt 1368121 ggcgaaaagg tacttgtgac ggcggaacag ggggaatggg tttctgtgat cgtgcctagc 1368181 cagccatccc gaaaggatcc gcgcggatac ccgggctgga tgaaaaagta ccagctggaa 1368241 aaaacaaagc ccatccatac acaacacgat gtgatgatca gcaaacctgc tgcctttttg 1368301 tacagaagca atggggaaaa ggagatcgaa ttaagctttt tgacagttct gccccttatt 1368361 gcaaaagaaa acggatattt taaggtttcg accgtttttg gggaaaggtt tgtgaggcaa 1368421 agtgatgcag tgcctgtcag ccaacagaaa gggactgctg aagacatcat tcaaacgggt 1368481 gcgttttttc ttggccttcc ctacctgtgg ggagggatca gcgggtttgg gtttgattgc 1368541 tccggattta tgtacagtat atttaaggcg aatggataca gcatcccccg tgatgcggga 1368601 gatcaggcta aggcagggaa gggtgtcccg cttgatgata tgaaagccgg tgatctgctg 1368661 ttttttgctt atgaggaagg aaaaggagcg attcatcacg tcggtctgta tgtaggcggc 1368721 gggaaaatgc ttcattctcc aaagacaggg aagtcaatcg aaatcctcac attaacagag 1368781 acaatctatg aaaaagaatt atgtgcggtg cgccgctgtt tttcagaata aggagggaga 1368841 caaatgaggc gactgccttt gttagaggtc agccagctga aaatgcattt tgacgcaggg 1368901 aaaaagcgga cagtcaaagc tgtcgacggg gtcacctttc agattcgtga aggagaaacg 1368961 ttcgggctag tcggggaatc agggtgcggg aaatcaacct tggggagagt gctgatgcgc 1369021 ctttatcagc cgacagaagg aagcgtgaca taccgcggca caaatcttca tgcactaagt 1369081 gaaaaagagc agtttgcctt caaccgcaaa ctgcagatga tttttcagga cccttatgct 1369141 tcacttaacc cgcgcatgac cgttcgagaa attattttgg agccgatgga gattcataat 1369201 ctctacaata cccataaagc acggcttctc gtcgtggacg agctgcttga ggcagttggg 1369261 cttcaccccg attttggcag ccgttatccg catgaattca gcggcgggca aaggcagaga 1369321 atcgggattg cgagagcact gtcgctgaat cctgaattta tcgtggcgga cgaaccgatt 1369381 tctgcacttg atgtctctgt tcaagcgcag gtggtcaacc tgctgaagcg gcttcaaaaa 1369441 gagaaagggc ttacgttttt attcattgcc catgatcttt cgatggtgaa gcatatcagt 1369501 gacaggatcg gtgttatgta cttaggacac atgatggaaa ttacagagag cggcaccttg 1369561 tatcgtgaac cgctccatcc ctatacaaag gcgcttttgt cctcgattcc gattccagat 1369621 cctgaattgg aggacaagcg tgagcgtatt ctcttgaaag gggagctgcc gagcccggtc 1369681 aatccgccaa gcggctgcgt gtttcgtacc cgctgtccgg aggcgatgcc tgaatgtgga 1369741 gaatctcgtc cccagcttca agaaatcgaa cccggccgtt ttgtcgcttg ccatttgtat 1369801 cgaaatgctg aaacgaagga aaaagtaaga taaataaaaa gagtggctcc tttttactag 1369861 agccactcca tttgtttata cttgatgtaa aaactttaca caaaccgggt aagggacaga 1369921 aaccgttgat gggaggagtg tcaatcggcc ggtttctttg tctctttcaa acaagacaag 1369981 gttgcctgtt tcttcatttg aagcaacgag gaacccttcc gttgggtcaa atacaaagtc 1370041 acgaggccag tttccttctg tcgacactct ttctacgaaa gccagctctc ctgaatattg 1370101 attcacttca aatacggcga tactgtcatg gccgcggttt gcgacataaa caaaacgtcc 1370161 gtcctgcgtg acatgtattg cgcttccctg gctgttatct gtaaaatcat cagggatggc 1370221 agaaacgact tggatttctc taaattcgcc ggctgtcggg ttgtattcaa gcgcaatcac 1370281 ttcattgctt aattctgtca tgacataagc gtatttttct ttcggatgaa aagcgatatg 1370341 gcgaggtcct gcaccgggag cgaaggaatg gcttccggat tcagtcaaca caccgtcttt 1370401 aagcttatag gtgtagagct tatctatacc taaatcaacc gctaccacat aattgtgttc 1370461 aggtgtgaac cccgcgtagt gtgtatgcgg tttttcttgt ctttcgtgcg gcccttttcc 1370521 tgtgtgagcg gcctctgaaa caggtgattg caagctgccg tcttcctgaa ccggaaaaac 1370581 gtgtaccttc ccgctgtgat aattggcagt cagtacgaat tgattttgat catcaacgct 1370641 tacgtggcat ggcgaagggc catcaattaa ctgatgattc agaaatgtca attcgccgct 1370701 gtttttatcg atttgatagg cagcaactcc gccttggccg tctgcttttt cgatggaata 1370761 aaggatggtg ttgtttttat tcgtcgccac atatgtcggg ttgcccagct tagcggccag 1370821 ctttggctcg ctgagtgctt ttttctcagt atcaagctca aatgaataaa ttccttcgct 1370881 tccgcctttt gtatatgttc ccacatatcc tatgtatttt gtcatgcgat ttccccctta 1370941 aaaatgatgt cacctctata ttaacgtatc ttgataaaat aagctgttca aaacatgaaa 1371001 aaggggaaga ttcttcattc gcctcgaatc agcggcattg tgcagcacct gaaggagccg 1371061 cctgatttaa taatttctga caggtcaatt tcgataatgt gatagcctct tttcgatagc 1371121 tgttgattga catggcggtt gccagggaga ctgatgatcg ttttttttcc gattgaaagg 1371181 acgttggtgc caagcgtaaa ttgttcgtcc tcgggcacct caataagatc ataacgtttt 1371241 gccagcatat cggctgcatc tggctcaatg gcctgtgaat aaattaacgc ttcgctttca 1371301 gatataatgt taaatacgca gtccaaatgc aaaaattttt catgaagctt cactggaacg 1371361 atcgtatatt caggaagtgc ctcttctagc tggccgatag ctgaaatgtc ggtgcgctgg 1371421 ctgattccga catagacaat gtcatcatcg ataatgacgt ctccgccttc aatactcgta 1371481 tcaagcatgc gggtgtaaga gataccttgg ctgtgaaaaa aatcttttat aacggcttct 1371541 tctccttggc gaatcggttc agtcatgctt gacagaaagg ctttttctcc gatgacaaat 1371601 cctatgtccc tagtaaaaac ctgttctggg agtccgtcgc gaacgggcaa aaggacgacc 1371661 tcaacgttgt gtgacctaag tgcctccact aagcggctgt gctggtcgtt agcggttttt 1371721 acatgaatat tgtcatcttc aaaatgtttt tgtgtttcgt ttataacatc ttttatggtc 1371781 atgtgctcag gtttgcataa gatcactttt tgaagtgtgc cgtattccgt tcggcatacc 1371841 gttttgtgct gagatttcgg gatggatacg tccatttgtt tttcctccta aagtgtgaag 1371901 aatacattta ttattccctc atcatgaaaa tcattaaacc attttaaatt ttagacaaat 1371961 ggaagagaat attgtttaat aggagaatat aagtgcattt agctaaaaga tcagacatca 1372021 aaggggagaa aggtatggaa acaccggaaa caagattttg taaagagtca aaggttgtga 1372081 aaaccagcag ggtgttcccg cttgacacga acaaccataa tacgctgttt ggcggaaaat 1372141 taatgagcta catagacgac attgcctcta tttcagcggc gcgccattgc agacgtgaaa 1372201 cggtaacagc ttcaatggat tctgtagatt ttttaaagcc gatcgggcaa aaggattctg 1372261 tctgcctaga gtcatatgtg acatgggtcg gcacatcttc catggaagta tttgtgaaag 1372321 ttattaagga gcatttgatg actggcgaac gggaactcgc tgccacatcc tttttgacat 1372381 ttgtcgcatt agattcaaat ggcaagccgg tgcctgtacc gagggttgta ccggaaacag 1372441 aagaagaaat catgctgcat aatacagctg tacagcgtgc taatgaacgt aagaaccgca 1372501 agagacacag ccaggcgctt gcaaatgcgc tcggaactga taagccttgg tgaacgttaa 1372561 acccaaaaca taagttgttt tgggtttttt tgtacttttc aatggtgatt attacaatgg 1372621 ttagtccgtt tttgctaggg gattctataa aaaagcaaca aatgtcatgt taaattgata 1372681 attttgtgac aactttatta aagattcatt ttagatatat cttttattcg taagatcatg 1372741 tattttaaag atatatttta aatacatctt ttcgaaagga ttgtttataa aatgttagat 1372801 aacaaaacaa tcgaaattat taaaagcact gtacccgtat tgcaacagca tggagaaaca 1372861 atcactggcc gtttttacga tcggatgttt caagaccatc cagagctttt gaacattttt 1372921 aatcaaacaa accaaaagaa aaaaacacag cgaactgcac tggcaaatgc cgttattgca 1372981 gctgcggcaa acattgacca attaggaaac atcattccgg ttgtcaaaca aatcggccac 1373041 aagcaccgca gtatcggaat taagcctgag cactacccaa tcgtcggtaa atatttgctg 1373101 attgcgatta aagatgtatt gggagacgct gcaactcctg acattatgca ggcatgggaa 1373161 aaagcgtacg gagtcattgc tgacgcgttc atcggaattg aaaaagacat gtatgaacag 1373221 gctgaagagc aagccggcgg ctggaaggag tataagccat tcgttatcgc aaaaaaagag 1373281 cgggaaagca aagaaattac atccttctat ttgaaaccgg aagacagcaa gccgttacct 1373341 gaattccaag cagggcaata tatcagcatc aaagtgcgga ttcctgattc tgaatatacg 1373401 catatccgcc agtacagcct gtctgatatg ccgggaaaag actattatcg aatttcagtg 1373461 aagaaagatg gtgtcgtgtc ttcctactta cacgatgggc tgcaggaggg agattcaata 1373521 gagatcagcg caccggcagg ggactttgtt ttagatcatg catcacaaaa agatctcgtt 1373581 ttgatcagtg ccggagttgg cattacacca atgatcagca tgctgaaaac atctgtttcc 1373641 aaacagcctg aacggcaaat tctgttcatt catgcggcga aaaacagtga atatcatgca 1373701 ttgcgccatg aagtagaaga agcagcaaaa cattctgctg ttaaaacagc atttgtgtat 1373761 cgcgagccga cagaggaaga ccgtgcaggt gatctgcatt ttcatgaagg acagattgat 1373821 cagcaattcc tcaaagaact gattgccaac acagatgcgg attactatat ttgcggttca 1373881 ccgtcgttta ttacggcaat gcataagctt gtatcagagc tcggatcagc gccggagtct 1373941 atccattacg agctattcgg cccgcaatta agtttggcgc agtccgtttg aacacataca 1374001 tgaaactctt ctcctttcag agaagagttt tttattgaga tataagaagg cagacaagcg 1374061 ccggtttcta catccggaca atcacagacc cgctgccatt tgtgcataca cggttttgct 1374121 gttcttgcat tgttctcagc aattcattgt ttacctcaat cgctctaatt agttgcttca 1374181 ttcttagctc caaaccggcc agcctgtcga ttgtttgctg ctggtagccc tcgggttggg 1374241 gagccaatgg cagatcaaag ggccaaaggg tattcgactt ctgatttttc atattgcgta 1374301 ttgcgcctcc aatcggtgtc actttctatt atgttatgtt caggcgatat gcacgttcgc 1374361 ctagacactg atgcatagag ggcctgccac ggggcacaat aggctcaata tgaccagcgg 1374421 atggaggtaa agatcggtgt tatggatggt atgggtattt ttactgaagc cagttatcgt 1374481 attttcgatt gcatatattt tgtttcggct tgccggtaaa aaagctgtgt cacaaatgaa 1374541 caattttgac ctgcttttga ccttcgcaat cggaaccatt atcagtgagc cgatccttac 1374601 atccaagctg ccgatgtcaa tttattatgc gggtgctttt ttggtgcttt atcttatcat 1374661 gagcaagctc tctttatcta ataaatggcg atggctccta gtcgtgagcc cgactgtcct 1374721 aatccgaaac ggggatattg atgaacgcgg ccttcgtaaa gaaaggctga ctgttaatga 1374781 gctgctcgga aagctgaggg aaaagggcta tgccgacccg gctgacattg atcttgctat 1374841 cattgaagaa acgggagaag taagcgtcat cccgaaagag gaagcgagag cggtgcaggt 1374901 gcgggatttg aatatggaag ctgaacggaa ttttatcccg attccgctca tactggatgg 1374961 cgaaatcctt gatcataatt tgaaatatct ccaaaaaaac cgatcctggc tgtttgagaa 1375021 gcttgaggaa aaagggtaca gccccaaact gctgtcttcg attatccttg gcacgatgaa 1375081 tgcacgcggt gatatatccc ttgatttaaa taccgctaat gaaccgcagc atgatcctta 1375141 cttatataaa ccgggaaata acaattaaga tggctctctc ttgtaatgag agcttttttc 1375201 ttttttaaag ggaatttttg tttggtgtca aatgtaccta gttaggaggg gaactgaaca 1375261 tgaaggactt atccataaga aacgacatgg cgccaacggt cagtttgctg tattccgcag 1375321 tggaagaaaa cagtctccgt ctggcttcca tcgtaagcca tatgacacac agtgaacttt 1375381 actataaggg gcgctgccaa acaaaaaaca gcacggctca gcttttgcac catatcacaa 1375441 atgttgatat cagatgggtc tggcgtatca aggaaaatcg gatcccggac catattgaac 1375501 aggcatacgg cccgatgaca gatgaaagcg gacggctgcc tgaaccggtg aatcagccag 1375561 acttagatga actcctgaaa agacatcagc atgtagtaga gaagctgaaa tcggtatgct 1375621 tcactttaac tgaaaatgct ttgaaccagc cgctttcctt cgaaggtgac accgcgacga 1375681 tacgatgggg aatttggcat atggcagatc ataaccgcta tcatcaggca catattgaag 1375741 ctctcaaaaa agaatggaag caggatgtgg cgaagtatga acgctaaaac gaagcttgtg 1375801 actgatcgaa ttcgtttgcg ctgtatggaa gatcgggatc aagccacttt gtttgggctg 1375861 ctttttaatg atcctgacgt catgacatat tattccggtt taaaagataa gaggcaaacc 1375921 cgcgagtggg tcaattggaa ccaacgaaat gaaaaagggt acggcgttag tctgtggatc 1375981 gccgaagata agcggacagg ggagtttttg gggcaatgcg gcatcgttcc ccagcagatc 1376041 gaaaatcaaa ccgtaatgga aattggctat atgtttgccc gccgccactg ggggaacggc 1376101 tatgcgcaag aagcggctcg ggcctgtctg gactatggct ttaacgagcg gcagttcggc 1376161 aaaatggcgg ctttgattga tccgggtaac aaagcgtcca tacgggtagc ggagaaaatc 1376221 ggcatgcatt acagcaaaac gatcagaaaa tggaataaac cgatcgcggt atatgaaaga 1376281 aaatcttaca attgaaagat agagctgagt ttagtatcat gatatcatgt aaagttttct 1376341 agggttccgc atgtcaattg acatggactg gtccgagaga aaacacatac gcgtaaatag 1376401 aagcgcgtat gcacacggag ggaaaaaagc ccgggagagt caatctcatg tgagacgact 1376461 gtccggggtt tttttgtttt cggagaatct taatagatag aaaggaatga ctcaaaatga 1376521 aatggggatt ggtcgtgctt gccgctgttt tcgaggttgt ttgggtgata ggcttaaagc 1376581 acgctgactc agccttaaca tggagcggca ctgccatcgg catcatattc agcttttacc 1376641 ttctaatgaa ggcgactcac agtctgcctg ttggtaccgt gtatgccgtc tttaccgggc 1376701 tcggcacagc gggaacagta cttagtgaaa tcgttctttt tcatgaaccg gttggatggc 1376761 cgaagctatt gttaattggc gtgctcttaa tcggtgtaat cgggttgaag cttgtgacac 1376821 aggatgagac agaggaaaaa ggaggcgagg cataatgctg cactggatca gtttattgtg 1376881 cgcgggctgt ttagaaatgg ccggcgtggc ccttatgaat caatatgcga aagaaaaaag 1376941 cgtgaaatgg gtgctgttga tcattgttgg ttttgccgct tcattttcct tgctgtcgta 1377001 cgcaatggaa accactccga tgggaacggc ttacgcggtc tggacaggaa ttggcaccgc 1377061 cggcggggcg cttatcggca tcctctttta caaggagcag aaagacgcca aacggatctt 1377121 ctttatcgcg ttgattttat gctcagcagt tggtttaaaa attctgtcat aaattgattt 1377181 ttatcaaatc ttcagtataa tggataaata gtttagactt acaaagataa gagggattat 1377241 tcatgaaatc atatatgact cagcggttgg acgaataccg tgacggaaat gaggataaag 1377301 gtcggctctt ggtcagctgc cccgatcagc cgggtatcgt ctctgcagtt tccgcgtttt 1377361 tatttgaaca cggtgccaat attatagaat caaatcaata tacgacagac cctgaaggcg 1377421 gccggttctt cctgagaatc gaattcgact gcgcaggcat tcgtgaaaaa aaatcatcac 1377481 ttcaggcagc gtttgcctct gttgcggaaa aattcgacat gacatggagc ttaactttgg 1377541 cgagcgaact gaagcgtgtc gccattttcg tttcaaagga gctccactgc ctgcatgagc 1377601 tgatttggga atggcaaacc ggcaacctga tggcggagat cgctgttgtc atcagtaacc 1377661 atgaggaagc gagagagctg gttgagcgcc tgaacattcc attccactat atgaaagcga 1377721 acaaagacat cagagcggaa gtcgaaaaga agcagcttga actgctggag cagtacgatg 1377781 ttgatgtgat cgtgctcgca cgctatatgc agattctaac tcctgatttt gtttcggctc 1377841 atccgaatcg catcatcaat atccaccatt cattcctgcc agcttttatc ggtgcgaatc 1377901 cgtacaaacg ggcctacgag cgcggcgtga aactgatcgg tgcgacatct cattatgtga 1377961 caaacgatct tgatgaaggg ccgatcattg aacaggatat tgagcgtgtg gaccaccgcg 1378021 ataatgcgga agcgctgaaa aacatcggaa gaacaattga gcgcagcgtg cttgcccgtg 1378081 ctgtgaaatg gcatttggaa gaccgtgtca tcgttcatga aaataaaaca atcgtcttta 1378141 actagactgc aagaggcccg cgcaatgcgg gctatttttg atgacaaaaa accttgacaa 1378201 gtgtcttttt tctttgcata atataaaaaa atcattgagc gttgaagagg attagtaagc 1378261 agacctttct gtgacagaga gcaaaatgaa tcgctgaaac attttgccgc atgaaacctg 1378321 ccgaacctgc cttggagtcc tagggggaaa acctaggcgc ataacctggc gttacaggag 1378381 agcggagcgt gcacaagcgc gttcaatcaa ggtggtacca cggaaaccca tttcgtcctt 1378441 atgaatcagg atgaaatggg tttttttatt gtagaagagc cgcggaggag aataaatgaa 1378501 aaaacaaaga atagtagtga aaataggaag cagttcgctc acgaatagca aaggaagcat 1378561 tgatgaggca aaaatcagag agcatgttca ggcgatttcc gtgttaaaaa aagcggggca 1378621 tgaaatgatt ctgattacct cgggtgccgt agcggcgggg ttttccagcc tcggttatcc 1378681 atcccgtccc gttaccatca aaggaaaaca ggcggcggcc gcggtcggac aaacactgtt 1378741 aatgcagcaa tatatgaatc aatttaaaca atactcactg actccgggac aaatcctttt 1378801 aacgagaaat gatttttcga aaagagaacg gtatcgaaac gcgtatgcta cgataatgga 1378861 attattagag cggggcgtca ttccgattat caacgagaac gattctacat ctgttgaaga 1378921 attgacattc ggagataatg atatgctttc tgcgttagtc agcggattga ttcacgcgga 1378981 ccagctcatg attctcactg acattaacgg actgtatgat gccaatccaa atgaaaatcc 1379041 tgaggcgaaa cgatttgatt atttgccaga gatcacgcct gaattgcttg gatatgcagg 1379101 ttcagctgga tcaaaggtcg gcaccggcgg aatgaaatca aagctgttag ccacacaaac 1379161 cgcgctgtct ctgggagtga aagtattcat tggaactggc agcggagagc aaaaacttgc 1379221 ggacattttg gacggcaggg gagacggcac ttatatcgga gacaaagaac tatcttcggt 1379281 taacaacaca aggcagtgga ttcagttcca ctcgccgata tcgggagaaa ttatcattga 1379341 tgcgggtgcc gaagaggcga tgatccataa tggaagcagc cttttgcccg ctggagttgt 1379401 gggcgtgaac ggaagctttc cgaaaggggc ggttgtggaa gtcaggggac cgggcggcgt 1379461 gatcggcaaa ggccaaactc attactcctc cgaggagatt atggaggcta aaggcaaacg 1379521 cagtgacgaa cttgattttg agaaaacgtt tgaggttatt cataggaatg actgggtcaa 1379581 tgtaaaagac taggaggcgg aaaaatgagt gaagtttctg taaaagcgaa gctggcgaaa 1379641 gaagcagcag ccgaaatgat catgaaaaca acagccgaga aggatgaggc gctcagcctc 1379701 attgcaaacg gactccgcaa agaactggat tttctcttgg cggagaatgc aaaagacatt 1379761 gtgaacggaa aagagaatgg tttaacaccg gacatcattg accgtctctc attggatgag 1379821 aaacggatac gcgatatcgc ggacgcggtg gagctcttaa tcgacttagc ggacccaatc 1379881 ggcgactctc ttgaaacgat tgaaaaagaa aacggcctgt ttattgaaaa aatccgtgtg 1379941 ccgctcggtg tcgtaggaat gatttatgag gcgaggccaa acgtcacagt tgatgcggct 1380001 accctttgcc tgaagacagg gaacgcggtt gtgctgcggg gaagctcctc agccatccac 1380061 agcaacaaag cgctcgtcag tgtcatttac agagcacttg agcaatcagc gcttccgatt 1380121 cacgctgtgc agctgattga ggatacgagc agagagacag caaaagagct ctttacgtta 1380181 aatgatggct tagacgtatt gattccgcgc ggaggcaaga aactgattga tctcgttgtg 1380241 agagaatcaa cagttcctgt attagaaacg ggagcaggaa actgccacat attcattgac 1380301 gaaacagcca aaccgcaaat ggcagaaaag gttgttgtaa atgccaaaac gcagcgccct 1380361 tctgtatgca acgcgattga atcattgctg attcacaagg cttgggcaag acagcacgga 1380421 aaagaattgc tggaccagct ggaaaacgcg ggagttgaaa ttcgcggtga tgaattggta 1380481 tgtgaacttc atccttcaag caaacaagca tcaaaagaag attgggaaac cgaattttta 1380541 gcgcctgtcc tcagcgtaaa gacggttgaa aacgtccaag aagctgtaaa gcatatccaa 1380601 caatacggca ccaatcattc tgaagcgatt ttaactgaaa atgacaaaaa tgcggtatat 1380661 tttcaaacgg ctgtcgatgc tgccgctgtc tatcataacg cgtcaacccg ctttaccgac 1380721 ggctttgaat tcggctacgg agccgaaatc ggcatcagca cgcaaaagct tcatgcaaga 1380781 ggaccgatgg ggcttcctgc actgacttct acaaaataca tcattaaagg aactgggcaa 1380841 atccgtgaat agcggggtaa tgttcaatga aaaagcttat ctcattacga gataagcttt 1380901 tttatacgcg aaaaattgac atttcaaatt taattgtgta caatttaatt gtataaaata 1380961 tattggggga atgaaaaatg agtcagccat tatttaccgc aactgtttca gcggtaggag 1381021 gaagagaagg aaaggtcatt tcatcagacc gcgttcttga gcttgatgtc gcaatgccgg 1381081 ggacaccgag agccaagaaa ttagaaaaag cgacaaatcc agagcagctg tttgcagcag 1381141 gttatgcagc ttgctttgac agcgccctgc agcttgtcgc aagaacagaa cgggtaaaag 1381201 tagagacaga ggttacagca aatgttagcc tgttaaagga tgaagcggac cagggctata 1381261 agctgggtgt gacgctgcaa gtaaaaggag aaggagtcag tgcatcagaa ttggaggcgc 1381321 ttgtgaaaaa agcgcacggc gtctgcccgt actcaaaagc aacctccgga aatattgatg 1381381 tgacacttga agttgctgaa taaataaaaa gaggatgcct gtacaaggca tcctcaattt 1381441 ttttgatgaa gtgtttccag taatgtatat agagcggact ttaactgttt gagatcctcc 1381501 ccagactgct ttgagagccc cagaattgtc cctggaatgt caaccgcttt ttcttttaat 1381561 aacgctccgt cctctgtcag gctgatcaac acggaccgct catcctcttc agatcttttt 1381621 ctcgtaatca aaccctgttg ttccattcgt ttaagcatcg gagtgagcgt tcctgaatct 1381681 aaatacagct gttcgcccat ttttttgaca gtaagcgttt catgttccca taacaaaagc 1381741 aaagccaaat attgagggta tgttatattc agcttatcaa gcagcggctt gtattgcttt 1381801 gtcatctccc gcgaactcgc atatagcaaa aaacaaagct gattctccaa tttcatatga 1381861 tcaaatttat tttccatttt gttcaccaac tcttttttgt cattcgattc tattgtatct 1381921 gaaaaacctc acttttccta ttctcggcaa acatagcatg tttaaaaaga tcagaaaggg 1381981 aaatataaca actagataca aataaggagg ttgggaaata tggcactatt tacagcaaaa 1382041 gtaaccgcgc gaggcggacg agcaggacat attacatcag atgacggtgt tcttgatttt 1382101 gatattgtca tgccaaatgc caaaaaagaa ggacaaaccg gcacaaatcc ggaacagctc 1382161 tttgcggcag ggtatgctgc atgcttcggc ggcgcgctcg aacacgtagc caaagagcag 1382221 aatatcgaaa ttgattcgga gattgaaggg caggtcagcc tcatgaagga tgagagcgac 1382281 ggcgggttta aaatcggtgt cacacttgtt gtgaacacga aagatttaga tcgggaaaag 1382341 gcacaagagc ttgtcaacgc cgctcatgaa ttctgtcctt actcaaaggc aaccagagga 1382401 aatgttgatg taaaactaga attaaaataa tgaccggcat cctgaggatt ctcaggatgt 1382461 tttttggtgt cggacatgcg gggcgggcac agatttatga taaaacttca gagaagcgtt 1382521 tgaagcatgc ctttaaacca aaagttacag atgaagcggg tggctggcac ggtgtctgcc 1382581 gtgctgaatt gcgcgtatat gctgttttgt atttgcacag ggcatagcgg ctacttggag 1382641 aaataacaag gaccaggccg cgcatgcctg atccttttaa tattctttct tattggcgaa 1382701 gttccgccat gcttgaaacg gggataaatg ctctgttagt gtcacttgat aaaaggggat 1382761 cgttctttct tcagcaggtt tatcaatttc tttataaatg aatgaatcat caaacccggc 1382821 ttcggcagcg tctgtgtgct cagctgcata gaaaacggct ttaggccggg cccagtagat 1382881 ggcgcccaag cacattgggc atggttcaca gctcgtatac aaaatgcagt catcaagctg 1382941 gtaggctcct agcaccttac aggctttccg aatagctgtg acttccgcgt gggcagtcgg 1383001 atcattgctt gttgtgacgt tgttctgtcc ctctgcaata atggctccgt ctttcacgat 1383061 aacggctcca aaaggcccgc cgattcctgc attcactcct tcacatgcga gagtgacagc 1383121 ccgttttaag aacgtttcat gattcatccc aatccctcct gtcaatagag tgttattagt 1383181 atagccgaaa agaatgcaaa gaacattctt aaaaaagtgc aaaataaaca aagtatttgg 1383241 gggatttgct aaataagaaa ccgattgtgg ctgtattata gaaaaaaacc atctgccaaa 1383301 tgcagatggt tttttcaaat tatactagct gtgtctgctg tgctcttgcc tgttttgcgg 1383361 cttcaaccat atttttcaat gctgcaaccg tttcttcctg ctgtcttgtt ttcaatccgc 1383421 agtctggatt tacccagaag cggtcagtcg gacagacggc aagcgcatca acgataatat 1383481 tgtacatttc ttcagttgac ggcacacgag ggctgtgaat gtcatataca ccaaggccaa 1383541 gccctttcaa atacgggtgg ttttttaagt aatctaaaaa tcctccgtgg cttctgctat 1383601 gttcgattgt aatcacatcg gcatcaagat cattgattgt atcaacgata tcttcgaagt 1383661 tgctgtagca catatgtgta tgaatttgtg tctcgttttt cacggaagaa gtggttaatc 1383721 tgaaagcttc tgccgcccaa gtcaaatact catcccaatc gcgggttttc aatggaaggc 1383781 cttcacgcag cgctggttca tcgacttgaa tgatttgaat gcctgcgtct tcaagcgctt 1383841 taacttcttt gcgaagggca agcccgattt ggaaggcgat ttctttcctc gagatgtcgt 1383901 ttcgagggaa agaccagttt aagattgtaa ccgggcccgt cagcattcct ttcacatgct 1383961 tggaagtcaa tgactgtgcg tagactgtgt ctttcactgt catcggttca ataaattcaa 1384021 catctccgta aatgactggc gggcggacac agcgtgagcc gtatgattga acccaggcat 1384081 atttagtgaa ggcgaaaccg gccagctttt caccgaagta ttcgaccatg tctgtccgtt 1384141 caaattcgcc gtgaacaagg acatcaagct ccaattcttc ctgaatatca atccatcttt 1384201 ttgtttccgc attgataaag ttttgatact gttcatcgga ccactcagct ttccgccatt 1384261 tttggcgtgc gctccgcact tcagcagact gcgggaagct gccgatcgtt gtcgtcggca 1384321 aaagcggaag gccgagagat tcattttgta gggctaaacg ttcttcaaac ggaatcgggc 1384381 gcttgaagtc tttatcagtt aattgctcaa gctctttctt ttgttcagaa ttggcgcctg 1384441 ttgcaaactg tttaagcgcc tggatatcag ccttagcctg ctgaatctct tcgctgatcg 1384501 ccgcttttcc tgatactaag ccttctttca aagctgtcag ctcggccagc ttttcttttg 1384561 cgtaggataa tccgttcaat aggtcttttt ccaaatgctc atcagggtgt ttcgctactg 1384621 gaacatgcag caggctgctg gaaggctgaa tccacagttc atcaactttt gcaatgctga 1384681 gaatatcaag aacggcatcg agacgctctt caaggtccgc tttccaaatg ttgcgtccgt 1384741 cgataacgcc ggctgccagc actttatctg tcgggaagcc atgtgtttta agctgttcca 1384801 ggtttctgcc tttgtcgtga acgaaatcaa ggccaattcc ctgaaccggg taagagatca 1384861 gctcttcata agcatcaaca gaatcaaaat acgtctgcaa aagcacattc aaggatgaaa 1384921 gctcacttgt aatgctttca aataattctt ttgcgccgcg tacatcttca ctagaggcgg 1384981 taacgagcgc cggctcatcg atttgaaccc attttacgcc ttcttcttca agctctttca 1385041 aaagctgtac atataatggc acaaggcgtt tttggatcgc ttttgcttca gacggttcat 1385101 agcctttagc aagcgtaacg aacgtataag ggccgacaat cacaggcttt gtttccacac 1385161 cgtattcctg tttgatccgg cgataatctt cgagttgttt gtttcttgtc agacggaact 1385221 caatgctctc gtcatattcc ggaacgatgt aatggtaatt tgtattaaac cattttgtca 1385281 tttcactaga tacagcgtct ttgattccgc gggcgatagc gaagtatgta tcggtagcgt 1385341 cagtcaaatg tctgaaccgt ttcgggatcc agttgaagct gactgctgtg tcgagtacat 1385401 ggtcatactg tgtgaaatca gaaacaggca caacatcaat ctgctggtca atttgtgttt 1385461 ttactgcgga taaaaatagt tcgtcgattt gcttcaaaaa cgtatcttta tcagtactgc 1385521 ctttccaata cgcttcaagt gcttttttcc attcccggtt cagtccgatt ctcggaaatc 1385581 ctaaattcga tgttttgatg gttgtcattg tttctcctcc tttatatgta aaacactctc 1385641 tttcacccgc ggatacaggc tgctaagagg ttttctcaca acaaaaagcc tctttcccat 1385701 gagagaaaga ggcttttcta cgtaaaacac tgcctctctc atctctcaga cacaatctga 1385761 tggaattagc accgtgcctt atgagacatc agtctcggcg cgaaaagcag tgcgccccat 1385821 ttcacaatgg tattacggtc ggttgctgtt ggggtcaaaa ggccaatccc tcgcccaact 1385881 ctcgataaga gaaaatgtta ttaatttttt gaaaagttga atcatttgtt ggtaatctta 1385941 acagtaattc aaattcattg tcaacataga atttgaaatt tttatttaca tgatgtggtg 1386001 tatattatat aagaaaaata atcttatagg gtcaacaaat gtgattgctc tgctttttct 1386061 gcgagctcat caggagctgt taaatacagg aatccattgc ctgccagcgt ttttgcaata 1386121 tcaagaggaa gtgtcctgcg gattagctgt gcgaaaacct cagattcaga aagctttctt 1386181 tgaaatgatt cttcttcata gcttttgatt aaagcaagcg caccgctgac atgaggggca 1386241 gccattgaag tgccggtcag cttaccgtac ttcttgttgg gaagggtgga taagatgttt 1386301 tctcctggtg ccacaaggtc aatctcttta ttcgcgttag aaaattctga taattctcgc 1386361 gctacagaaa cagatccaac tgcaatcact tcattataag ctgcggggta ggaaagctct 1386421 tctgtgcgtt cgtcgccgtc accttcattt cccgctgcac aaacgacaag cactccgttt 1386481 ttcactgcgt ttttcactgc ttcttttagc tctggcacat cgcttggccc tccaagggac 1386541 attgagatga tgtcgacttt ctgttccacc gcgtagttga tgccgttaat tatccattcg 1386601 tattgtccgc tgccgttctc gccgccaaga accttcacaa tcaataggct tgcctcaggc 1386661 gcgactccgg caatgcctcc gtttgaatca ttagctgcaa ttgttccggc gacgtgtgtg 1386721 ccgtgtccgt tgtagtcgga aatcgcatct tccttgccgc cgtcgtcatc cgtgaagttc 1386781 tttccgccga tgatttgatt ttttaaatca gggtggcttg tgtcgcagcc tgtgtctaat 1386841 acagcaactt taatattttt gccttttacc ccttttgccc acatttctgg cgccttaatc 1386901 actttaatgc cctcaggaag ctcgtttaca tccatgatct gctcattcgt cacatacggg 1386961 atcaagcgga tttcaccatt cataaaaaag ccctcctttt ttatgcttgc aagtggattc 1387021 aagggtgttg cctcatatta tatgaaaaaa gcaagcgctc ggacagagcc atttgaagca 1387081 ttttgaaaaa ataggataca caccaaagaa ttagtaatct tcaaaatatt ggatggcttc 1387141 aacatgtatg actgggattc aactgtaagt caagttataa tagtgttggg gaaaggagca 1387201 gtgtcatgaa actgaatgaa aaattatatg catttttttc agagcatgtg gaacaaatgg 1387261 ccgaggaatg gattgaaacg atggaggaaa gtgatccgaa ttcgctttac gccctacata 1387321 atgcaacagt aacggaagaa ttgaaagagc aggacagaga attttaccgg catctgaatt 1387381 acatgtatgt tttaccggaa aaacaatttc tcgaagagtt tcaagagtgg gtcattgagc 1387441 tgaccaacga tcaaaaacat ctcgacacac cggttcagta tgtcattcgg gagtttatga 1387501 gaaacaggag attatatacg aagtattttg agaagttcgc agaagaaaat gaatcagcgt 1387561 ttgaaccggg agagaagcaa aaatgggcag atttgattgt aaaagtattt gatttcacca 1387621 tttatacatt cgttgatcac gctgaaatga atgccaagca gcaattaaac gcccaaagag 1387681 aaatgatatt ggaattaagc tcacctgtca ttaccctgag caaatcaaca gctctgctgc 1387741 cgcttgtcgg tgacattgat accgaacggg cgaagtttat tctggaaaac acgcttcaag 1387801 cttgtgcgaa aagacgtgtg gagcatctgt taatcgatct gtcaggtgtt gttgtggtgg 1387861 atacgatggt ggcgcaccag atctttaaat tgattgaggc gcttaatctg atcggtgtcc 1387921 ggtcaaccct gtcaggaatc aggcctgaaa ttgcgcaaac tgctgtacag ctggggattg 1387981 acttttcgaa tattactatt aaaaccaacc ttgcccaagc attaaactat catcaataaa 1388041 aaaatccgct atctgtgata gcggattttt tatgatgcga aacataaaga tacgagaaag 1388101 gatcccgcga ataataagag gacgaggcaa aagaacaccc agtcgcgccg gttcacgctc 1388161 aatgtcctgt agtatgtccg gtttctgctt cctgtaaatc ctttcgattc catcgcaagc 1388221 gctgtccgtt ccgcttttct gatggcgctt gccaatagcg gtatggtata tcgttttaac 1388281 gcactgattt tattaatgat gccgctctcc gccgctcctc ctctgatttt atgagcctgc 1388341 tgaatcagct ggacctcatc ctttaacagc ggaagaaagc gaaagcctgc aatgacaccg 1388401 tacgcgagct ttggtgagag cctgcactgc tggacaaggc tcagcataaa tagaatcgga 1388461 tcggttgtaa aaacaaacat catcgataag gcggaaaagc ataaaatacg aaacccgaga 1388521 gagatgccga cagacacatt atcgctgtta atggagatag ggcctgcttg aaacaaaaaa 1388581 ttatccggtg ttgtcggcac ttttccaaaa actgcggctg tccacacgca tccgaatgct 1388641 aaaatcaaaa acggaatcgt aaacaacaac cattttttca atgggattcc ggccgccagt 1388701 aaaacgcccg caacgatgat gatataaaaa catgccggag tgtaagggtt gtaaataaac 1388761 gacagcatga cgacacaaca aaaaaccgcc gccgctttca cagtcggatt aatgagatgt 1388821 aacggttgct tcatcacgca cctcctcttg aaatgccatc cattcatata gaaggggaag 1388881 ggtgagcttt gctttttgaa caagccctgt ttcttgagaa aacaactgcg ctggagatcc 1388941 gtcaaaggcc aggcctgtat cgtgaagcac aagcacgctg tcagcatacg aagagactag 1389001 ctccatatcg tgtgtaatca taaggacagc agttccctct gccttgatac gttgaatcat 1389061 ttccatgcat tcagccgccg tgcgggcatc ctggccaaag gttggttcgt ctaataataa 1389121 aacctttacg tcatgcatga gcatagtagc tacgctcagt cgccgttttt gcccttggct 1389181 gatcgcaaac ggatgatgat cagccaaatg cgcaagacca aaacgctgca gcaggtgttg 1389241 cgcttttttc tcagtttcag catttgcttt ctggccgaac agaagctcgt catacaccgt 1389301 atcggtgacg aattgatgct cagggttttg aaaaacaaat cccatccgtt tacgcaattc 1389361 tttttcttta tatttctgca gcggctgatc atagagaagg attttgccgc tttgcggttt 1389421 catgagactg gccagaactg ataggagcgt cgattttcca gttccgttcg gaccgacaag 1389481 cgccgttaaa gagccttcgc gcaacgaaaa gctgatgtct ttgaaaatcg cctgctgtcc 1389541 tctcgcgaac gaaaggctgc tgacttcaag cacactctcc ccagaagggg ctttcttctt 1389601 tttgacatgc ccggcaggaa taggctcttt gaacagcatc tcttttgata aagtaaacgg 1389661 catactcagc ttttcctgca gatgacagac ctttggaatg gcgatgccca atttctttag 1389721 tgtctccgct tcatgctgaa atagattttt cgtcaggcca tccagtgcct ttttgcctga 1389781 tttgtcgagt acgatcgttc tctcaatcca aggcgcccat tcatcaagct ggtgctcaat 1389841 gacgaggagg ctgaaacctt tttcccgctg aagatccttc atcagatgaa cgaactcccg 1389901 agctgagaaa gggtctaaaa gagaggtcgg ctcatctaaa ataataagct caggctccat 1389961 cgccaaaata caggcgagag ccactttctg cttttgtcct cctgaaaggg ttgagatcat 1390021 tttttctttt aaatgggtaa tgcgtaattt ttctaatacg gcgttgattt tctctgtcat 1390081 ttcttctttt ggaatttgca gattttccag cccgaacgct atttcgtcct ccaccgtcag 1390141 catgcagaac tgctgatcag gatcctgaaa aacgaccccg gcatgctgag taatcgtttc 1390201 ggaggtttca gcatctgtga ccggcttttg aaatagaaat acatgtccgg actgaatgcc 1390261 gtcgcaagcc tccggatata gaccgtttaa acaaagggcg agcgagcttt taccgcatcc 1390321 gctcggtcct aataataaaa cacattctcc tttttgaagc tcaaacgaaa tgtcttgaaa 1390381 aaccggtttc tcgtcttctt cataagagaa gctgagctgc tcaaccgtca gaagctcatc 1390441 aaaggcttgc atgttctgac gcccgcttcc gtttcttttt cagttccttt ccgagtgcca 1390501 ttccgtttaa cacacctgta taagcgagag agtcgctgac agcttttccg agaagccccg 1390561 ccaaaagcgc gccggaaatg aggcggatca caagcataat gagcagataa cctggtgaat 1390621 aggctgcata gccagaaaca aagagatcat agataaagct ggctactgaa gaccccatac 1390681 cggccagcat aaggacaggg agagagtatg ctttccagcg tgttgcaaga aatacagcct 1390741 cagccccgag cccttgaaca atgccaatga cgatgaccat cgggccagac ggatttccca 1390801 gcaggcactc aacgagagcg gcaatgattt cagaaacgag cgccgcaccc ggttttcgaa 1390861 tcatgtacgc ggcgatcaca gaaacgataa accaaatgcc gtaaattggt tcataggcga 1390921 ttggcccaaa catacctgca agtacgtttc cgaaatgtgt aaataataaa taaacaacgg 1390981 caaatacgat actgataacg gacatgatga caatttcttt tactttccag cttttcatgt 1391041 tatccctgct ttctgttttt tcttgatgga ctgttagccg aaagattcac agtcatggtg 1391101 atgtggtttg tttgctgctc agccatgcgg aaaacggcct ccaatgtgct gaatacgtca 1391161 tgcgcatccc cgtcaagctc gctcgcgtaa tggacaccct gtacgaaagt gccttgggct 1391221 tttgcaatgt cgacagcctc cataatcaat cccatataat ccggctcatt cattggataa 1391281 agggcaaatt ggcacggcgc ttccgccttc aagcctcgga cagcatcttc attgacacgc 1391341 ttatcacctt tggaaagata tgtatccccc tgtgtgtcac ccgggcatcc aatggaaaac 1391401 gtgccgttca tgacgatgtg ttgttcgctg tttgctgcat gaaggtaaat ggcttttgca 1391461 gcatcgaata catgatcaat cgatccgcgt aacaccgtgc tgatatggtc ggttttcgtc 1391521 caaaccttgg atgtatctgt ttttttcagc gcagacttga tcacactgat aaaatcatcc 1391581 gtcatcggat ataaagagaa gcgaaaaccg gcgattctgc ttgtaccgca aatatgctcc 1391641 atttctccga cctcctgttt ttttggtaaa ataaaaaact gcatatccta agggaatatg 1391701 cagtcataga tcgattaagc gcacaaaaaa atacaccatt cggtcaacct gcacttcccc 1391761 acgctggtat tatccagatc gggtcataag ggatcaaagc gcgtttcttc cgcgctttat 1391821 ctcagccaaa acagcacccc tagtgctttc cgtatacaat tttttatttt gacatcataa 1391881 tagatgataa gaatcatttt gtaaacaacg aaatcatttt tttcatatag ggacgggaga 1391941 ggatggtcaa atttggaaaa aggacacata ttaattgtgg aagatgaaga aaaaatcgcc 1392001 agggttcttc agcttgaatt ggaatatgaa ggatacagcg tcacgatcaa acacaatggc 1392061 acagaaggtc ttgatgcggc agcggaaggc gggtattcct tggtgcttct tgatgtcatg 1392121 cttccggggc ttagcggact ggaagtgctg cgccgcttga gaaaaacgga ttcgcagaca 1392181 ccggtcatat tattaacggc gcgagacagt attcctgata aggtaacagg tctggacatc 1392241 ggtgcaaatg actatgtcac caagccgttt gaaatcgagg aattgcttgc gagaatcagg 1392301 gcggcgctgc ggcaaaatgg aacaaaaact gaagatatcg gcacctttct tacatatgac 1392361 gatttgcggg tgaacgaaaa aacccgtgaa gtgagacgcg gagacaaaga ggtggaatta 1392421 acgccgcggg aatttgatct gctcgtctat atgctaaagc atccgcagca agtgctgaca 1392481 cgggagcaaa ttctaagctc agtatgggga tttgattata tcggtgatac aaatgtcgtg 1392541 gacgtctaca taagatacat cagaaaaaaa ctggactatc cttacgaaaa acagctgatc 1392601 catacgattc gcggggtcgg ctatgccatt aaggggtaaa cgatgaagct gaagaccaag 1392661 attcatctat acacttcgat atcactgttg attttattaa ttttggttca taccgcagta 1392721 tatctcattt tttcgtctgc gctgacatca aaggatgcgg cccggcttgc tgatgagacg 1392781 gataacattg ccgaagcgct gcgtgccgct gaaacagaag gagtggcttt gcaggatatg 1392841 ctgcaggcct atcttccggc aaatggcatg gtgcgtgtag tgaatggtga tcaaaaagcc 1392901 gttatgacga tcacaaaaga aaaagcctat aaagattttc ctctctcttt tcatagcggc 1392961 gaaacggcag atgtgaggaa acctgacggc aagctgtttg ccgaggctgc tgttccggtg 1393021 atttggaccg atggacaagt cgtgtctctt cagctggttg aaagactgga gaacacagaa 1393081 gagagtctgt ttctgctgaa aatcatctta atcgctgcaa gtgctgctgt ctgcattgct 1393141 tctttttttg caggcagctt gctagcccgc cgaatcatca atccgatcag acgattaatg 1393201 atcacaatga aagacataca gcgagacaaa gaatttaaaa cgatttcttt agaaggacag 1393261 tccaacgatg aattgtatca aatggggctg acatttaatg aaatggcaat gatgctgaag 1393321 gagcactatg ataaacagca gcaatttgtt caagatgctt cacacgaatt gaaaaccccg 1393381 ctcactatta tagaaagcta cagcagcctg atgaagcggt ggggtgcaaa aaagccggag 1393441 gtgcttgagg agtcgataga agccattcac tcagaagcgg tgcatatgaa aaaactgacc 1393501 aatcagcttt tggcgctggc caaaagccat caaggactcg aggttgatct gaaaacaatc 1393561 gatctgatta aagcggcgcg cgcggttatg caaacgctcc agtccgttta tcagcgtgac 1393621 atattgcttg aaacagataa agagagcctg cttgtaaagg cagatgaaga acgcatcaag 1393681 cagctgttga ccattttgct tgataatgca ataaagtata gtgaaaagcc tattgagatg 1393741 tcagccggaa cgaggaatgg acggccattt ctatcagtga gggatgaagg catcggaata 1393801 cctgaggagc atatcccgca tttgttcgaa cggttctacc gggcagatga ggcacgaaac 1393861 agaaaaacag gcggaacagg tttaggcctt tccattgcca agcaaatcgc tgatgagcat 1393921 ggcattgagc tgtctgtcaa aagcaagccg ggacaaggaa cagctgtcac catgcaattc 1393981 agcgaacaga atgggggagg ccgatgacta aaacaataaa aacagtatct tttgctgcag 1394041 cagccatttt agttgtcatc atctgtacgt ttctcatcat tcggcaaacc catgagaacg 1394101 tattgtcaaa ggagactgtc gtaaaaaaag tcgaagcctc ttatgaaggc aaggtcacga 1394161 aagcaacaca atcaaaggat aaaaaaacat atgatataac ccttgaaaat ccaaagggaa 1394221 cttactttgt aaaagcagac gcaatatcgg ctgacattct ttcaatgaat agagtaaaag 1394281 cagtgaatcc atctgccatg acagaaaaag aagccgagca tctcgcgctt gagcgggtgc 1394341 cgggaacggt caaaaaacaa acacggcaaa gtcaagttgc cacttatacc atacaaaaag 1394401 aagacgggaa aacatacgaa gtgaaggtag acatgcaggc aaaaacagtc ttgtctgccg 1394461 atcaaatcag cagcaaagat caacaaaaaa cgccgattac gaaaaaagaa gccaaaacaa 1394521 ttgcagagcg aaaaacgggc ggaacagcgg atgacgcaga tctcgaagaa agtgagggca 1394581 ctctcatctt tgaagtagac gttgatcttc ctgataataa ggaagcgaca gtgaaaatca 1394641 atgcctacac aggaaaggta gctaacattg tgtatgaaga ctgacggttt ctcatcaaat 1394701 tctcatcttg ctctcgtttt cctttcatgt tgagtatgta aactgtactc atacaaaaca 1394761 aaggagggct cacaaatgct caagaaaaaa tggatggtcg gtcttttagc agggtgccta 1394821 gcggccggag gattcagcta caacgcgttt gccacagaaa acaatgaaaa cagacaggct 1394881 tcttctaaga cggatgcact cactgaacaa gaagcagaag caattgctaa aacagttgtt 1394941 gacggcacag tagaagacat tgacagagac ctttacaacg gcaaagaagt ctatgaagtg 1395001 gagattgaaa aagaaggtga agactacgac gtttatgtag atattcatac aaaacaagcg 1395061 cttaatgacc cgttaaagga gaaagcagaa caagtcgcca taaccaaaga agaagctgaa 1395121 gaaattgctt taaagcaaac aggtggaacc gtaacagaaa gtaagcttga cgaagatgac 1395181 ggtgcttaca tctatgaaat ggaaatccaa acgaagcaag gaactgagac agaatttgaa 1395241 atttccgcaa aagatggacg cattatcaaa caggagatag atgactaatc aaaacccccg 1395301 ctgcagcggg ggtttttcat gataagaaac cttcttttgg acaatctaag tagaaaagga 1395361 ggcgaaacgc atggaaaaga aagaggagca atacatcaat caggctgaat atgtccctca 1395421 tccgacgaag gaaggagagt atgccttatt tcttcatgaa acgtatcatt tgctttctga 1395481 agatgacgag acacaaacaa cagaataagg gcttaggccc ttgttttgtt ccgtaattgt 1395541 gatgtaagcg catttattac ttttttgagt tgacatagct tgtttttttc tgtaatctca 1395601 gtgtgtcaat tcaattagga acttcgttag gtgaggctcc tgtatggaga tacgctgctg 1395661 cccaaaaatg tccaaagacg ccaatgggtc aacagaaatc atcgacataa ggtgattttt 1395721 aatgcagctg gatgcttgtc ctatgccata cagtgctaaa gctctacgat tgaaggcgcc 1395781 cgcacgcttt ttttgccgtg cttctttcac cttcaatccc gaaggctttt tttatgcctt 1395841 taaaacgaaa ccaatcaaag gaggtgcgga gtatggattc tccccattcg agtcaatctg 1395901 aagaagtacc catatactat gacagcaaga caattgatta cacgatgagg agacgaactg 1395961 ccgcaccttc tggcgaggcc ggcacgtctc cgtagaggag gtacgagtcc cgatggttca 1396021 aaacatgacc tatgacgaac tcattttacg catcattatt ttactgcgag acgggaaaat 1396081 cagggatttt agaagtgtta ttgatgagct tcagccctat gacatggcat ttatttttaa 1396141 agaaatgccg gaaaaacatc gcgcccgcta tttatcttat ttaactgtag acgatatcac 1396201 tgatatgatc ggggagctgg aacgcgaatt tcagcttgtc gtcttaaata aagtcggaaa 1396261 aacaaaagca acactggcga tgaacaaaat ggacaacgat gacctcgctc aattgcttga 1396321 agaaatggac gaagaactga aggaacagct tttatccagc atggaagcgt cagaatcaaa 1396381 agctgtacag ctcttgatga attacccggc tgattcagcg ggacgcatga tgacaaaccg 1396441 gtatgtgtgg atccctcagc attacacggt aaaagacgcg gtcgtcaaac tgaaaagctt 1396501 cgctgaaata gctgaatcga tcaactactt atatgttatt aatgaaagca aacagctggt 1396561 tggggttctt tcctaccgcg atttgattct gggtgaacct gaagaaaagg tgcaggattt 1396621 aatgtttacc cgcgtcatat cagcagatgc tcttcaggac caggaagaag ttgcccgcct 1396681 gatagaacgt tacgattttt tggcaatacc ggttgtagaa gaaaacaacg tgcttgtcgg 1396741 cattgtgacg gttgatgata ttatcgacgt tgttattcgg gaagctgatg aggattacga 1396801 aaaatttgcc gcttccggta aagacatcac ctttgacaca aaagcttacg tggcggcata 1396861 ccggcgtctg ccatggctga ttttactctt atttatcgga ctgatttcag gaagcattat 1396921 cagctatttt gaagacgcgc tgaagcaggt tgtcgcgctt gcgtttttca tgccgatggt 1396981 gtcagggatg acaggaaata cgggaacaca atctcttgcg gttgtcatca gaggtttgtc 1397041 taaagaagaa atgaacaaaa aaacgattgt gcgcctgatc ttccgggagt tcagaacaag 1397101 catttttatc ggagcggttt gttctgtgct gattgcgatt gtttctatca tatggcaggg 1397161 gaatgcgctt ttgggatttg ttgtcgcctc ttcactgttc ttaaccttaa tcatcggcac 1397221 gatgtcagga acgattatcc ctattatttt gcacaaactg aaagtagacc cggcgattgc 1397281 ttctggaccg ctgattacaa cgttaaacga tattttatct ttattaatct actttggcat 1397341 tgccactgca ttcattcact cattataaac gtaaaaagtc cgtctcaact gcgagccgga 1397401 cttttattat ttaacggttt ttgtaccgaa agtgagcatt aagctgcccc tccagcattt 1397461 ttttccgcac ttgcggatcg ttttttaaca tctgttcttt tttgcgcata tcctttaaaa 1397521 tctctgccgt ctgtacgccg tcttcacgct tattggcgat atccatcagc cgctccacat 1397581 cggcaaagga gtattttctt gtcccccttg aagaacgctg cgggtaaatg agctttcgtt 1397641 cctcataata cctgatctgt cttacggaca atcctgtcaa ttcactcaca attccgattg 1397701 aaatcacttt tttgtcttta taagaatgat cttctgtggt catttttcca cccctggatg 1397761 tcttttgata atagtatata aaaaacaaag agaaaaaacc tgacgcttgt catattttct 1397821 aacatcaaat agaagatttt tgaaaaaata cggaagaaaa attaacaaga ataatgcgta 1397881 acacccaagc gcgttttatc ctttatgtaa cgaatcaaac gaggaggaag gataatcatg 1397941 gaggaagaaa aagcagtctc actggcaaaa gaaattatag agttggatat caagcgtgat 1398001 gaaatgctgg agacgtttat gcagcttgcc ggagaacagg cttttcaatt attaagatcg 1398061 gttcaaaacg gacaataccg aaaatcttcg taaacataaa ttctttacat tagattcata 1398121 ccacgttcat ttaaaaagag tatcttttgt ataggatacc tcaaaatgaa ggaggacgct 1398181 atgagtaatt tattgaaatc cgctttagaa aaagaacgac gccattattc tgaaaaactc 1398241 tatcagatag gggtttataa taaagaggtc atgaacaaaa tgacgatttc tgagcttcgg 1398301 aaagaatacg cttatttctt tcgaagcatt acaaatcata aaaattatcc ttatacaaga 1398361 taatgtataa ggattttttt gcttttagaa ggaatttctc gaattatagc gaatacgtat 1398421 agtaagggac tgaactctta ttatatgtaa gggttttcat tattttttta taaaaatcct 1398481 atatacgagg tagatatgat gagattatcg tttaacgaag aagaagttga gcgtgcgatg 1398541 aatttgtaca gagtttttgc aagggctttc aaaagtgtgt ccgaacatag tatccgtgat 1398601 agcaaagagc acggttttaa tcccactgaa tttgctgtac tggaactcct gtacacaaga 1398661 ggcccgcaaa aattacagca aattgggtcg agacttctgc ttgtaagcgg aaacgtcaca 1398721 tatgttattg acaaactaga aagaaacggg tttttagtaa gggagcagga cccgaaagat 1398781 aaacgctctg tttacgcaca tttaactgac aagggaaatg agtatttgga taaaatttat 1398841 ccgattcatg cactgcgtat tgcgagagcg ttttcaggtc tttcgcctga tgaacaggac 1398901 cagctgatcg tcctgctcaa gaaagcaggc atacacagcc agcatttgct gtttcgttaa 1398961 ctattctaca ctctctattt caggagagtg tttttttgtt tccatatgat tctttttaaa 1399021 acatctttaa tcttcctatc agacatttcg ccaaggtatc cattgacgtg ttttttatac 1399081 tccttcatct gttcgttcga ttgaaaaaat gccgcgatat actcttctgc tttctgcatg 1399141 tcccagtttc tcatatctgt gacgagtttc ctttcatgta gaaggtttaa attcatttcc 1399201 tcctgtcccg gcagtgcatg ataaataaat accggaagcc gtttctgtaa gcattcactg 1399261 atggtcacgc ctccgggttt agtcatgatg cctgtcgcct gttcgtacaa acggttcatc 1399321 tctgctttgc tgtgaaggta aggaatcgcc tcaatcaagg ggtggtgtaa acttttgaca 1399381 taggagtaga gcttttcgtt tctgccgcat aatattttgt ataagatctt tccgcctggc 1399441 gacagttcct gcacccattt taaaatccca ccgaccccca tactgccccc tgtgatgatg 1399501 atggtatatg gcgggtggtg ctgcaaggta tctgctgatt ccatttcaaa attttggtga 1399561 actggaatgc cggtcaagta tatgttgttc tgatcgatac cctctgatat tagctgcttc 1399621 tttacttccg tgctcggaac aaaatggtaa tcaatgttct tccgtcccca taattgattc 1399681 acgaaaaaat cagtgtatac attcacaacc gtcagattcg gatattcagg ctttagtcgg 1399741 ttcagcagat aagaaggcag cgcatgtgtg cagaaggcga tatcaggctg tttttcttgg 1399801 aggatgtgcc tcatttgctg tgtgaacagc cattcgtaca tgaaatagcg tttgtcatgc 1399861 tgaaattctc cgcaggcgag gagcctgtaa atgccgctgt acgttttcgg gaaatattga 1399921 atccatttta aataagccac ggaggacaat ttttctaacc gcctatacga atgtgaaaag 1399981 atatcaatct tttcagctgc cagcccttga gactctaatt cagcctgcaa tgcatcagcc 1400041 acatgatgat ggccggtgga aatgcttaaa aaaggaaaaa tgagaatgtt tttcatgaca 1400101 gtcctcctaa aaaaatatgg caactatatt ttgaggagaa cgttcacaaa atataagggt 1400161 gtttttgatc ataaggaagg tgaaaagatg aaaacttgtt tcctttccat atggagagtg 1400221 gttgatccga tttatttctt tttttcaagg ctaagcttga ttgacaacga tcaaaaaagc 1400281 gtttttcgag tcaggctgac gaagtacaaa ggacatcatg tcgtgcttag cgacggaacg 1400341 catataagaa aaaatgatgt gctcgttaaa atccacctgc ataacataaa gctgatcagg 1400401 gagctgcaaa gcattgagag cgcagtcaga aagggaatca ttatttatca gaaagtatat 1400461 caatcgatgc cgcttcttct tgactatatc aacaatcata aaaaaagcga gaaaatcaaa 1400521 ggaatcattg ggattacaat gcttgacaaa ggtgtggaaa ggctcggctt tgatgtgatc 1400581 accccggtga acccttttta cagatgcttt aaaaaagtgt ctcatgtgcc gattttatat 1400641 ttgacttcaa agcctgtgag cttgcggcat ttaccgaatt catcctattt gtttatctca 1400701 aaagaaaagc tgcagaaaac ctatcaaaaa aaagactgat gcctcggtca gcacagtctt 1400761 ttttgattaa atctgatgaa atgtcacttc agggcggctt ccgacacgga tatttacgcc 1400821 ggtttgtccc aagccctcgc tgatataaaa tggtttatcg tgatgataat gaaggccttt 1400881 aatcatgttc attcgcacga gctttcccat tttcaccaaa tgatacggtt ttggccagtg 1400941 aatttgcccg ccgtgaaaat gccctgacag caggtaatca taatgaacat ctttcatatc 1401001 cagaataata tttgggtcat gtgttaagac aagatgatag ccattttcca gactttgata 1401061 agagccggtg atattactcc gattcgtact gtaatcatca atgccgataa tattgactgg 1401121 tcctgcagcc gtctcgattc gaacatgttc attttgcagc gtgatacagc cgttttcctc 1401181 taaaactcgc ttcaatctct gaaagtcctc ttctttcaat acataatcgt ggttaccgaa 1401241 caccgcgtac attccatatg caggctttag cttttgcaag gcgttcaagt aacctgccag 1401301 tttcggaata ttacgtttcc gatcaagaaa atccccggta agagcaatga tgtccacagg 1401361 ctgatctttt gttaaatgat acagctcctc aggtgagact gaaatgtttt ccaagtgaag 1401421 atcagataaa tgaaggatat ttaatttttt tctggctgga aggccgtctt tttggtcgat 1401481 tgaaatggtg ttgactttca catcttttgt attgcggttc gctttatata gaaatggcac 1401541 aaatacgagt atggccaatg aaagtaagat tgtaaacaaa atatatcccc tcccttctat 1401601 cagtatagta agtgatcaag ccctatggat agcgggaatt aatgggtaga gacaggttga 1401661 aaaacggatt gtcatatgat gaatgatttg gaagggaaaa gggataataa attttgacac 1401721 atgaggcaga acatgccgac ggagtcagaa taacaaatgg atgtgtaagc aatgttacga 1401781 ttgatgagac aacaaaaaaa agaaacatat tatctctgga tcgcattatt tcttctttta 1401841 ttgtatgtat ccccgctttt tattttaaag gaagatgccc atatccgggt ccacgataat 1401901 ttagattcca acatcgcttg gtacaaggtt ctggccgata gcggagaaat cgtcggcaag 1401961 gttgacgctg ccattccgca aatcattaac gggctgcccc gggatgcctt tggcaccgag 1402021 tggagcggaa ttgtttggct ccatgctttc ttttcttcca tgaccgccta tgcaataagc 1402081 cagacggtta caagagttgt cgcttttttt ggaatgtatg tgctgctgaa gaaacatata 1402141 atcccggaac caaaagcggc tttcatccga attggcgtat cgcttgcatt tgccttaaca 1402201 ccgttctggc cttcgggaat gctgagtacg cttgggtacc ctttggcact gtgggctttt 1402261 ttaaatatcc gaaaagggga tatctcatgg agagagtggc tgacgctggg cttgctccct 1402321 ctatactcaa gctttgttct aggcttcttc tttttcctgg cagggatggc gtgtttttgg 1402381 ctgtatgatg ccattacaaa aagaagatgg aatttgatgt tcttaggcag tattgcattt 1402441 atgacgagta tctatctttt cgttgaatat cggcttgtct attcgatgct gtttgagcac 1402501 gcaccgatgc atcgtatcga atttatctca tctaggcatg acgtttggca ttctcttcga 1402561 ctatccataa aaaactttgt ctatggccat aatcatgtga tgaccgttca taccgttgtc 1402621 atccttccga tcctgatggt cgtatttgct gctctgctgt tcaaacgaaa tcggacaaag 1402681 ccagaaaatg tttatctgtt tttatgtgtg cttaattacg ggttgtcatt atggtatgcg 1402741 ttttggttca acaaaatttg ggctgttcca aagcagaaat ttgctttttt agcagaattt 1402801 aattttgccc gttttcattt tcttcggccg cttgttatat acgtgagctt tgcgcttgct 1402861 ttatatctca tttggcggat ggggaaagga tggaaatggc ttgtgtacgc cgcagtcgct 1402921 gcacagctga tggtgttggc gccttttaat gaagaatata cgtatggtgt tcattacaac 1402981 gcgccgacat tcagggagtt ttatgcatca gagcaattca aagagattaa ggaatatatc 1403041 ggacgtccgc aagattcgta tagggtggcg agcatcggac tgcatccgtc tatcgcccaa 1403101 tataacgggt tttatacgtt agatacgtat aacaatctgt atccgctctc atataaatat 1403161 gaatttagaa aaatcatcga aaaagagctg gaaaaaaatt ctcggctgaa acaatacttt 1403221 gatgaatggg gcagccgctg ctaccttttt gtcgatgaac tcggtaaacg atatgatttc 1403281 aaaaagaact cgaagaaaac gatcaacaac cttcaattaa atacagatgt atttaaaaaa 1403341 atgggtggac ggtacatttt ttcttcagtt ccgatcatga atgctgaaca aaaccatctc 1403401 gcgctcgtaa agacgtttga ccataaagat tccgcctggc gcatttattt atatgaaaca 1403461 agataaggag gatatcgatt gaaacagtca cagccagtat taaccatcgt cgtcccgtgt 1403521 ttcaatgaag aggaagtgtt tcaagaaaca agccatcagc tgacagaggt tgtagatgat 1403581 ttaattgaag aaaaattaat tgctgaagac agtaaaattc tgtttgtcga tgatggcagc 1403641 aaagaccgca cttgggcttt gattgctatg gagagcataa gaaacaagaa ggttaccggc 1403701 ttaaaattag cctgcaatgt cggccaccaa aaagcgcttt tagccggatt gcataaagcg 1403761 aagaataggt cagactgcgt catttcgatc gatgctgatc ttcaggacga catctctgtg 1403821 atccgggatt ttatgctgaa atatcatgag ggctgcgaga tcgtttacgg tgtacgccgg 1403881 agcagaaaaa ccgatacctt tttcaagcgc acgaccgcgt tagggtttta tcgtctcatg 1403941 aataaacttg ggattaaatt aatttataat catgctgatt ttcgtttaat gaataaaagg 1404001 tcccttgaag agcttgagcg ttatccggaa gcgaatctgt ttttaagagg tattgtcccc 1404061 atgatcggct ttaaatcggc cgaagttttg tatgaccgca aggaacgctt tgccggcaaa 1404121 acgaaatatc cgctgaaaaa gatgctatcc ttcgctttta acgggattac ttcattcagt 1404181 gtcgcaccaa ttcgattctt tacgctttta gggtttgttt tgtttttcct cagcgctgtg 1404241 gcagggattg gcgcgtttat tcaaaagctg ctcggccata cgaatgcagg ctgggcgtct 1404301 cttatcatat ccatttggtt tttgggcggg ctgcaattga tgggaattgg aatcatcgga 1404361 gagtatattg gaacgatttt ttctgaagtg aaaagacggc cgaaatacgc gattgatatt 1404421 gatttgtata atgaacagct gagcccgctt cagcgccagg aaaaagagcg gttagaaaaa 1404481 aagtacagtt aaacacggaa agagctgact tcattagtca gctctttttc ttcaactgat 1404541 gcaatatagc gctaagcggt tcgtcttgcg ggttgcggta aaaatcaaaa aatgggcagc 1404601 cctgcttctt aattcgatcg atgaccgtat caattgtaaa cagagcgggt gttaaagatg 1404661 attgcacctc atgccagtag agcggggctg caacagtccc aagctcattt cctctcgttg 1404721 aatagggaca gataatcgtt tttccttctg catgctgcaa ataatcaaga tacaatttgc 1404781 agtgtctgtt tttaatcaag cgttcagtgg taaagagctc gggaaatgca ttggtgcagt 1404841 actctgcgat cagctgcgta aattggcgtg tttcttcata cgtaaatgcc tcgggagaca 1404901 agggaatata aagctggatg cctttgttgc cggacagctt cgggtacgat gtgatgccaa 1404961 aggaatccaa cagccgcttc agttcatttg cggcctgcac ggccataaga aagtcatctc 1405021 gcgaaggcgg gtctaaatca atgacaatct cagccggacg cctgctttta atggtttgaa 1405081 aaggaacgtg aaactccaaa gcaagctggt tgcaaagcca tagcaatgta gacatatcct 1405141 cacagacaat atgttcatgg cttccatcat agaaagactg aacaaaatcc ggcgcatagt 1405201 ccggcttgtt tttttggaaa aatgattcgc tcctagatcc atgcggatag cggatgacgg 1405261 tgacagcccg gtttttcaga aatgggagca ggtagtcact gacttcaatc atatactgaa 1405321 taaaatcttc ttttgttttt ttattctttt caaatatgat tttatccagg cttgtgaact 1405381 ggagctttgg gtgaaccggt ttggagtgtc gtatgacttg cgcatacgtg cattcggtcc 1405441 agtccatttg gaattcgaaa ccgataaacg atacctctct taatgtgcct tggagaattg 1405501 ttaagtattg aacagctgca caaatcgaag gttcaagcgt aaattcgcct gagggtgttt 1405561 gatgtccgtg ctgttccata atctcgcgta tagcgctttt ttcctcatca cgcattccgt 1405621 gcgagacaga ggcaatcggt gtcattattc cgttttttaa caccgatacc gtcagaaacc 1405681 cgttgttagg gttgaaccct gttatgcaaa cataagcttg tttaaagttt ttatatttga 1405741 gccaatcgga cgaccgcttc ttttcaagcc atttgctgtt tgttttcttc gctacaattc 1405801 cttctccgtc atattttatt accatctccc agagttgatc aaaatgatca taacagggaa 1405861 tggattgaat ggtttctttt gcgtaaggat ctggagatgc aggaagcttt gctgcggata 1405921 tgagttcacg cagcgatttt ttgcggtcca aatacgaaag aagcgttaca tcttctccgc 1405981 ttcgctctaa caaatcaaag gcgagaaagc agcacggccg cgcgtttgcc gattcctgaa 1406041 tcttgtctgg ccttttcaaa cgcccccgca cttgaaggtg ttcaaaatct gcacgacagg 1406101 gattcaccaa acatacgatt tcaccgtcaa gtgtcagcgg aagctctttt tctaggtgct 1406161 gaaaggcagt tttggcgaat tgtgtgattt cagggaaggt gctgctgagc tccacaccat 1406221 ttctgctggt taaggtcaca cctgaagaat ggatgcggag aatacagcgg tacccatcat 1406281 attttacttc gtaacgccat tctgctccga ttggcggtga cgaagttaag accggctgca 1406341 tggtaaacgc catgcgctat gatgtgccgg aggctttttt tctagttgtt ttttgttttt 1406401 tatctccggc tcctttcggt tcagcggctt gtgcaggtgc ggcagccggt gtctcccggt 1406461 tcggccttct ggttctgtcg atgctggctt gcagagcgct taccaggtca atgacatctt 1406521 cacgaggtgg cgctttatca ggagtgacag ccgtttcttt attttctagc ttgtcgttga 1406581 ctctttgcag cagcgcctgt cggtacgtgt cttcatattt ctcaggctca aacttagcag 1406641 tcagttcatc tattaatgtg atagcagttt gcagttcctt atcgtttaca ttcgattgat 1406701 caggtacacc tgggacttga gcggcgcttc tgacctcatc gggataatgg atagactcca 1406761 tgacgataca attttcataa acgcggagaa tcgccagctg ctgctttgac ctgattgtca 1406821 tattggcgat accgatcttt ccggttgagc gcagcgcctc acgcagcagg gtataggcct 1406881 tcgtcccatt atccccgggg ccgacaaagt aggagcggtt aaaataaatc ggatcaattt 1406941 cctgaagctg aacaaagtca acaatctcaa ctgctttctc ctcatgctcc tgttttaagc 1407001 tttttaaatc ttcgtctgtc agcactacat attttccttt tacatattca tatcccttca 1407061 caatttcatc aggactaaga gttttttcgc aatttgtgca aactttctcg tatttgattg 1407121 gtgcgtgatc ctctttatgg aggctgcgca gtttaatatc tttatcttct gtggccgcat 1407181 atagcttgat ggggatgttt actaatccga agctgatcga tcccttccac attgtatgca 1407241 tatcgataaa cccctttttt tctttagtgt gaagagaagg agtacgattc atgtgtagta 1407301 acttatgggt gaaaaaaagc cggcgctgtt attgcgacgg ctgttcaata atgaattgtt 1407361 cgaattgttc cggaggtatt ggcctgctga aaaagaagcc ctgcaaatgg tcgcagcctt 1407421 tttcaaaaag aagctgcttt tgagctgcat tttccacacc ttcggcaatc acctgcaaag 1407481 acagctgatg ccccatggca ataatagctc cggtaatttg ctctgattta ggatgggtct 1407541 gaatatcgtc aataaatgat ttgtcaatct tcagcctgtg aatcgggaag tccttcaaat 1407601 agctaagaga gctgtgacca gtaccgaaat cgtcaatact gattctgatt cctaattctg 1407661 ttagggatga caaaaccttt ttggagtgat tgagattgtc cattgtcatg ctttccgtca 1407721 cctccacttc aagaagctgc ggaggaagct ggtacttatt aagcgtatcc ttgatgaggg 1407781 gaatcagatc tttagattga aactgtctgg cggaaatatt aatggcgaca gaaagatcat 1407841 agcctttgtc atgccaaatc cttgcctgct tgcatgcttc atctataatc cactttccga 1407901 tatcaataat aagtcccgtt tcttctgcaa caccgatgaa ttctccgggc ggacgcagtt 1407961 gcccgtctgg tgtcacaagg cgtatcagtg cttctgctcc tgtcattttt tgttttttca 1408021 cactgaattg cggctgataa tgcaagacaa atctatcgtt ttcgattgct tctctgagta 1408081 ccatctcttg gttaagctta acggtttctt tgttgccgat tgaaaaagaa tagtatctgt 1408141 atttgctttt gtttcgttct ttagccgcat acatcgccat atcagccttt ttcatcaatt 1408201 caaggccatc cgtcccgtct tttggagata tcgcaatccc gatactgaca gatgtgacaa 1408261 gggtgtgatc ttgaattttg aaaggttttt tgaatttttg gataattttt cttgctaaaa 1408321 catctgcttc gcctgttcct gtattggcgt ctgttaatat aataataaat tcatcaccgc 1408381 caagacgggc gataaatccg ttatcaggga ctacagatga caggcgttta gctgcaaact 1408441 gaagcaattg atcaccgaca ttatgcccta atgcatcgtt aatcacttta aaccggttta 1408501 agtcaagaaa gaatacaaca gtgttataat gcaaggaatg ctcgcgattc agcacctttg 1408561 ttagatgaga gatggcatgc cttctgttag gtaagtctgt aagcgaatca taatgagcca 1408621 ttctatggat ttctttttct gctttgtact gcttcgtcat gtctttacaa atgacataaa 1408681 tgctgtctag ttcctgattg acctcaacag gtataagcgt aatatttaag tgaaactggc 1408741 ctttttcagt gataagatcg ctatcgctgt tcatcgcttg tttatctttt ttaacttgct 1408801 caaaaaggcg cttaaccttc agtgatgtgt aattcctcca gtcatgcatg ctgaagccaa 1408861 atttgctgat catttcctca ccagcgtgat tggaagatat tatgtctcct tctaatgata 1408921 aaataaaaat tgcatcaata ttgtggacga ttaaagactg aaatcgctgt tcgttatcct 1408981 ttatgcgttc gctctgttta ataaactttc gatctgcatg ggaactgaat aacaataacg 1409041 tttggataca aaaaataatt aaagtaacaa aaattgacca atgaaacgtt tgcacctcca 1409101 tatggcttcc gggcggagcc atgtccttat ggaaagttgc cgcaagcatc cctgtgtagt 1409161 gcatgcccga aatcccaatg cccattacaa ttgaactgac gcctttatag aatataagat 1409221 gctcagaatg tttttttacg gccaagtcaa agaatatttt taacgagacg aaagaggctg 1409281 caatcgcaat gataattgaa actgtaaata aaataggttc gtaaataatc attacccggg 1409341 aaatggcaga cattccgata tagtgcatag aagcaataga tgcgccaagc acaactgatc 1409401 cggtaagcag tctgtaatat gtaagaatgt gccggctgac aaaatataat gacacaaatg 1409461 atcccgaaac agatgcgcca atggctgcca ttaaaggcat gaattcatat tccatcggca 1409521 tttccatatg gacggccatc atccctacaa aatgcattga ccaaataccg aatcccataa 1409581 taagtgagcc gccgatcagc caaattttac tttttaagcc tgtattgatg gtgactttcc 1409641 ttgaaagttc aagggaaata tacgaggcgg tacaggcaat tagaatagat aaacatatga 1409701 gagtcgtatt atatgtaacg tgtatttcca aatggagatt ccccccgtat cgtgtgttcc 1409761 agtcttgttg actctcttta ttatcggctg cttaaccgca gagtttcagc cttcaaaacg 1409821 atagaaatac gagggagatc tatttttagt tcaactgacc gtgaaaaatg tgttaaaatc 1409881 atcttgatgt tttccgaaaa gagaaaaatg tatgatacat aaacatgaaa caagggagtt 1409941 ggtggctatc gaagagctgg ttatgtcatg gattgaagca tttaaaagct tatcttattt 1410001 tggaatattt ctagcgctca gcattgagtt tattccggcc gaagtcgtct tgccgcttgc 1410061 gggctattgg gtatctaaag gcgatatgac acttgctggc gttgttttgg caggatcgct 1410121 tggaggagtg gccggtccgc ttacgctgta ttggataggc cggtacggag gaaggccgtt 1410181 tcttgaacgt tttgggaagt atctctttat taaacctgaa gcgcttgata agtcagataa 1410241 ttttttcaaa aaacatgggg gctttgtcgc cttcagcggc cgtttcttgc ctggtatcag 1410301 gacattgatt tccataccgt gcggaattgc aaaaatgaat gtttgggtgt tttcgcttta 1410361 tacattcatt gctatgcttc cgattacatt tgtatatgtt tatctcggtg tgaagctcgg 1410421 tgaaaattgg aaggcagtcg gctctattct tgatcaatat atgcttccga tcgggatagc 1410481 gattttggcg ctgttcctgc tctacttact gatgaaaaag aggaagaaac gcacgcactc 1410541 cgaacaatta tctgtatttt tgaaaaataa acgttgacaa atcactgcgc tgcgcatatt 1410601 attgacgtat aaaatcatat ttcttgaaat cccaaagggg agtagcgtcc ggaatgtatt 1410661 ccggaaacaa agtcgtcatt tcatggattg tatccatcgg ctttgttggc atgcctgaat 1410721 tcatgtctag caagaccttt gccttatgtc ggcaaaggtc ttttttgcat ggtccggccg 1410781 gcataagatc ggatgaagag aaagaaaaca acttttttgg gagggtatca tttatggatg 1410841 cagcattatt attagagtat ggttgggttc ttctcgtctt gatcgggctg gaagggattt 1410901 tagccgccga taacgcgctg gttatggcgg taatggtaaa acatttgccg gaggaaaaaa 1410961 gaaaaaaagc gttattttat ggattggcag gggcttttgt tctgcgattt ggctctttat 1411021 ttgcaatttc tttcttggtc aacgtatggc aggttcaagc gattggcgcg atctatttgc 1411081 tgtatatctc agcaagccac ttattgaaaa gatatgtatt taagaaagaa gacacacata 1411141 aagagacgaa gcaaagcggt ttttggccga ctgttttaaa agttgaactg gcagatatcg 1411201 cgtttgctgt tgattccatc ttagcagcag tagcgctggc ggttacactt cctgggacat 1411261 cactcccgaa gatcggcgga cttgacggag gacaatttct cgtcattttg gccggcggta 1411321 tcatcggact ggtgatcatg cggtttgcgg cttccatgtt tgtgaagtta ttaaaggaac 1411381 gtccaagcct agaaacagca gcctttgtga ttgtcggctg ggtcggagtg aagcttgctt 1411441 tatatacgct tgcccatcgc gacatagcgg ttgtttctga gcactttatc cattctggaa 1411501 catggaagct gatattctgg ggtgtcttag cagcaatcgc ggtttgcggc tggtttatgt 1411561 caggtgggaa aaaacagccg gagggtgcac aaaacgaaca aaaaaacagc acccgtgaac 1411621 gggcgtaatc tgaaagactc tgcttaaaag cagagtcttt ttgtgtttga agcgttttca 1411681 taagcgaaat aaaataacat ttttataaca tctttgttac aaaaaacacg cataaaaccc 1411741 ccttaattct ttagaaaggc acgaaatcat gtatagaacg tcagaatggt ttgtcataat 1411801 tgagacattg gaaatcaata tttctttttc tcctttgcga atccctatca aattagctat 1411861 cattaatgag tagttatagg gaggaactga ggtgaaacca gtgcttagcc ttttgtttaa 1411921 attgggaaaa aagaagcaaa cacttgaaaa agctgttgag agtatacaaa aaggcaataa 1411981 agatctgcaa aatgaattaa tacagcaata taagccattt atcgcaaaga cggtttcatc 1412041 cgtttgtaaa cgatatatag atgaaaaaga cgatgagttc agtattggac tgatcgcgtt 1412101 taatgaagct atagaaaaat attcacctga aaaaggaaat tctctgctcg catttgctga 1412161 gcttattata aaaagaaaag tcattgatta cattagaaaa gaagccagaa gcgcacaaaa 1412221 tataaatatc gatttacagg aaggagacga tcaggagtca tcacaaagcc tgattgaagc 1412281 cgagctttcc attgatgaat accgccgtca gattgaacag gagcagaggc gggaggaaat 1412341 cctctatttt caaaagcagc tcaaggatta tggtttatcg tttaaagaac tgcttgaaaa 1412401 ttctccaaaa cacacggatg caaggcaaaa cgccataaag gtggcaatga cgcttgttga 1412461 acatgaagaa ttggccgcta tcctgtatac aaagaagcag cttccggtca aacagcttga 1412521 acagcttgtc tctgtaagcc gaaaaacgat tgagagaaac agaaaatata ttattgcgat 1412581 gtgtattatc attacgggtg attatattta tttaaaagat tatcttaaag gggtgctgca 1412641 ctcatgagaa gagggattat agtagagaaa aataaaaaat tcgtcacgtt gctgacccct 1412701 gacggacaat ttttaaaagc caaaaatgat cgacacagct atgaaatcgg agaagaaatc 1412761 atgcttccga gtgaaacacg catgggcaga agggccagct tttttgattt ttttaaactg 1412821 cgccctttca aaatggggat ttttacgatg actgctatta tgctctttat ttttatagtt 1412881 ctccccgttt tttctaataa taaggcctat gcgtatatga caatcgatat caatccaagc 1412941 gtcgaaatgg cgttaaacag cgattatgaa gtgattgaac tgacgcctct aaacgatgag 1413001 ggacagaaag tcgtgaatga tatagatgat tgggagaaga ctgattttaa aaaggtgatt 1413061 gacgatatta taaccgactg cagtgaacac gggtatgtaa aaaaatcgaa agaaatattg 1413121 atttccactg tttatgaaaa cacagaagac aatacatata aaaaggctgt gaaaaaacag 1413181 ctgaatgatg tgactgaaaa atataaaacg acataccgca tggaatctct cgagtcagat 1413241 atgcaaacga gggaaaaagc gaagaaagaa ggcgtctcaa caggcagcta catcaaatca 1413301 aatgaaaaga atgacaataa agatataaaa gatgactcca gcaaaccatc cggggaagag 1413361 gatcaaaaga gtgatgaaaa tgaggatgaa aacaccgatc aaactgacac ccaggacagc 1413421 aagcaaggag ataatgaaca gctgaatgat gcggattccg gagaccagaa agaagagaaa 1413481 gcggatgacc agattgatga tagtgacaaa gataaaaaaa taaaggaatc agatgaaaac 1413541 acaaataccg aaaaagatgg ggaccatgag caaaccccaa tacaagatcc tcaagataaa 1413601 ggaaatgaaa ataacggcgc tgacaagggc caaagccaat atcacaggga ctggaacaat 1413661 ggtgaacaag gcaagaaccg ttcttcgtcc agaagggata acgcttcaga ccgacgtaat 1413721 ccaaacggct acagcagtga taatcattca gctaaaaatg aagattcgcc gagtgccccc 1413781 ggcgaataaa gacctgaatt tatttagttg tgccatttaa ttgtgattgt gcttgctgta 1413841 ccagccgctt tgtcatttct ccgcctacag agccgttagc gcgtgcgact gtatcagaac 1413901 caaggttcac accgaattct tgagccactt cgagtttaaa ttggtctagt gcctgctcca 1413961 cccctggaac aacgagttta tttctgctcg ccatcttttt catctccttt ttcgataaag 1414021 aaattcttaa cgcgtattta gtttgaaata tacggggttt atttatgctg gcaattgttg 1414081 tggagaaaaa taaaaccccg gcctctgagc cggggtggcg cagactatag aatgtctgct 1414141 gtcattttat gtgcggttgc ctgaatatgg aatgtcaaaa tggagaggac tgtaatggcg 1414201 ataatctgtc tgattttaag ccattggctg tcattcagtt cttcaaaacg gtgacggaga 1414261 cgctctgtct cctgttcggc gatctcctgc agatttgatt ctttcataga aggagtatct 1414321 tggtgatgga tggcatcaag cacatatgcg cagctttcat aataagcaat cgggctgatg 1414381 acatcatcag atctgtctga gattgtgtta aaggccactt ttaaaatagc ccgtatgtgt 1414441 tcaaagtcat aaatggattt taaatcacgt acaattaaaa gaataactgc ctgttcaatt 1414501 gagtattttt tgcccagctc agggtgtccg atcagatctt tgatatcacg ctttacccag 1414561 ttttgaatcg cggttgactt taacgaagtc agctcgcata agttgccaag ctctacgatt 1414621 tcatttgtag acagaccgta ttcttttttc tgtttttttc gttcgtatct tgtaagaaat 1414681 tcaggaattt ctagatgatt ggctgctttt tctgctgaca tgttcgctga ttggacgaga 1414741 atgtcgagcg ggctatgttc tccttgtcct tttagggaat agagcagccg caccatatcg 1414801 gttcgagaga gtttaaaaat gttcattgtt cacctcttta aacaatttga cgcggatata 1414861 ggtctatgta taagttcaaa attcaagcgt cagcaaatta cattaacatc atacgtcgaa 1414921 ttccttgcat tttcaaatgg atgttttata atttaaatat acgggttctt ttgaacttaa 1414981 aataacggag gttgttatgg cgaaaagaat ttttctgttt attctaacga atattttggt 1415041 gcttacaaca atcgggatcg ttttgtctgt tttaagctct gttacaggag tcgggacgta 1415101 ctttacagct gatggcggta tcgatccaat ggcgcttctt gtgttcagtt tagtcgttgg 1415161 atttgtcggt tcctttacgt ctcttgcgat atccagatgg atggcaaaga cgatgatggg 1415221 cgtcagagtg ctgaatccga aaaaacactc gctcagctat gaggaacagc aattggttga 1415281 tcgtgttcac agattaagcc gctctgccgg tttaacgaaa atgccggaag tcgggattta 1415341 ccgttcacct gaagtaaacg cgtttgcgac tggaccgtca aaacgccgtt cacttgtcgc 1415401 agtatcgtca gggctgctgg agcagatgga tgacgcagca gttgaaggtg tgcttgccca 1415461 cgaggtcgcg catatcacaa atggtgatat ggtaacaatg acgcttttac aaggtatcgt 1415521 taataccttt gtcgtctttt tatcgcgtat cgccgcttgg atagcaagcc gttttgtcaa 1415581 agaagatcta gcgccgatcg ttcattttat tgcaatgatt atttttcaga ttgtcttttc 1415641 gatacttggc agcctggttg tgtttgcgta ttcacgccat cgtgaattcc atgctgacag 1415701 gggaggagcg gatcttgccg gcaaggacaa gatgattcat gcgctgcgga cgcttaaaag 1415761 ctattcttcc cggattttgg aagacgatca gacagctgtc caaacgttaa agattaatgg 1415821 caagaagcgc tcttcacttt tctctactca tcctgattta gatgagcgaa tcagacggct 1415881 ggaagctaaa taatacaaac acattgttcc tctgagagaa ttctcagagg ttttttattt 1415941 tatccattga ctaaaatcat aaaaaaataa gcaagttaag aaaatgtttc gtaaaagcct 1416001 ttaaaaatgg acctaatatc tttagaataa ttaccgtact taaaaagaga ggcagaagga 1416061 ttttacatga gattaaagtt tggaaaattg atacaggcct tgtcaccggc ccagctgatc 1416121 gcattatatt attttcttgc agttactgtg gccgttatat tgctgagttt gccggcggcc 1416181 cataaaccgg gggcggattg gacgtttatt gatgcgcttt ttacagctgt cagttcagtc 1416241 agtgtaacgg ggctgacagt tgttgataca gctgatacat tcagcacaat agggattttt 1416301 atattagcat ttgttctgca atttggcgga atcggaatta tgacgctcgg aacgttcatt 1416361 tggctgatca tgggaaaacg aatcgggctg aaagaacgga agctgattat ggttgatcaa 1416421 aaccaatccc agttttcagg aattgtcaat ctgatgaagc aggtactgtt tctgatcttg 1416481 tggattgaat tttttggcgg gctgatactc ggcacatatt tcttaaccta ctatgactcc 1416541 tatcaggaag cctatttaca cggatttttt gccagtatca gtgcaacgac aaacggcgga 1416601 tttgatatta ccggtaattc gatgattcca tttcgccacg attactttgt gcagtttatt 1416661 acaatgcttt taattatatt tggagcgatt ggatttcccg tgcttgttga agtaaaggat 1416721 ttcctgtttt caaagcatcg gcgttatcca tttacgcttt ttacaaagat cacgacgatt 1416781 acgttcggct cacttgtctt gtttggagcc attggcatct ttgccctgga agcaaaccat 1416841 gcgttcgcag gaaaatcatg gcatgatatt ttgtttttgt ccctgtttca atcaacggca 1416901 acccgaagcg gggggctggc aacaatcgat atcagccaat tatcagattc cacactcttt 1416961 tttatttgtg cgctgatgtt tattggagcg tcgccaagct cagtcggggg aggcataagg 1417021 acaacgactt ttgctttgaa ccttcttgcg ctgtttcatt ttgcccgcgg caataaggcc 1417081 gtaaaggtat tcaaacggga gcttcaccct gctgacttga tgaagtcgct tgttgtcacg 1417141 atgatggcga tcctgctcgt ttttggcgcg acactcattc tgaccattac agaaaaacat 1417201 tccctgctgg agcttttgtt tgaagtgtgc tcggcattcg gtacaaccgg cctatcgctt 1417261 ggaattacgg cagatttgag cagtgttgga aaatgcgtca ttatgattgt catgtttatc 1417321 gggcgaatcg gcatcttgac cttcctgtat ctgatcggaa gaaaggaaat tgaagcgaat 1417381 tatcactatc cgaaggaaag agtgattatc ggataggcaa aacaccgcat attttgcggt 1417441 gttttttgat taccaaaaaa aagatgtgtg cctcctgttc agttggagaa cctaactccg 1417501 acaggtgcaa tttacgctcc tgcatcttaa aatgtctgaa aattggcgag gaggattcgt 1417561 atgaagcgta aagctgaagt gaatgaagcc attaaaaata acaatacacc taccgagagc 1417621 atggacccca attcatataa gacacaatat catgacgacc ccaattttag aggggcaaac 1417681 cgcaattcca aacagggcca gcagggaggc atgtaattgt gaagaaaaac cgtcatagca 1417741 gagacatgca aaatcataaa aagcctatga ataaaaaggt gctggaggaa gaattctcaa 1417801 gtgaactcgg ggattacaat gccggaaaga tcatcgaaac gctggaagtc accaagcctg 1417861 aaaagaaaaa agaaaaaaac aaaaaacaac aataaaaaag acctcttagg cggcgtcccg 1417921 cttaagaggt gctttttcta ttttaaataa gcatttttgc ccgttcctct gacaaattgc 1417981 aataagcttg tcatcctcag ctcaatgaat ggctgagcga ctgtcttaac aaagttgctg 1418041 gagaggactg atgtcagggc tgctgttaaa agcaagagga tcactaagct ttgatagtca 1418101 gtaagccaat cctcaagccc gacctgccgt aatgtcttaa taataaaccc gtgaagcaga 1418161 tacacgtaaa atgtccgggt tccccatttg gtaaagaaat accgtttttg cggaacgagc 1418221 gctaaaaagc tgaaggttgc cccaaaggcg agtacatacc agccgattcg ggatagtccg 1418281 cttaccaggg taacgtctcc aaatgaagaa tacggttttg aaccaaacag aaaagaatag 1418341 tcaaaatcga tgccccagca gatgacgaat actgcggcaa gcactccgag cgcaatttgt 1418401 ttgccgcgtt ttgatctcaa taaatcaaaa tgatgtttat ttaaataaaa accgacaagg 1418461 aacatcggta agaatacgaa tgtccgtgac aagctcagcg tgctgctgac aaagtccaga 1418521 taaccgatca gcacggcgat tccgcagctg acaaacagcg cccactgctt tgaaagcttt 1418581 gaaaaaggat ataggagcag gttccaaaag aataagctta caagaaacca taacgaccat 1418641 tgcggatcaa tcgggttcac atttgccatg ctttcatctt gcataatgta ataaaagacg 1418701 gaataaataa tttggaaaat caaatacgga ataatcagct tgaccgccag cttttttaca 1418761 tatcccgccc gtttaaagcc tttcgcgaaa taaccggata caagaataaa tgcaggcata 1418821 tggaatgtgt aaatgaactt gtagaggtag agcataaaat gattatcatt aataaaggaa 1418881 cgaaggatat gaccgaatac aacaaggaat atcaataaaa attttgcgtt atcgaaataa 1418941 ctgtcccgcg atttactcat agcatcacct tctctttcat cagtcactaa gagattattc 1419001 cctgctggta catattttaa aataaaagat gaaaaaggaa tctaaaaaaa tgctgattgt 1419061 taggtcgatg taaagtgacg gtaaggatcg tagaaaatgt cttcgtaatg taatgacgct 1419121 gaaattttct gaaatttata gggcaaatga aggaagttcc cgcattttgt agaaatattg 1419181 agggataggt tttgaagaag gagtgtacat gcatggaaac tcttggtgtc cagacaaact 1419241 cggagctgcg agaggaactg aatcgcctca aagaagaaaa cgcgcgactg aaaaaggaat 1419301 tgaatcagca tcaagtgatt gtcaacaata cgctcgatgc tatttttatt tgtgataacg 1419361 aaatgcggat tgttcaggca aatgaagcaa cagaaaggat gcttcaagtt gactcggaag 1419421 atttgaaaaa gcgttctgtt ttggattttt tgttttcaat cccaaaggat gaactgaatc 1419481 tttccgtaaa gaagtttttt aaaaaaggct ttctgtggaa ggaggttccg atcaggcttg 1419541 attgcggggc aacaaaatac atagagtttc tggccaaaag aggtattggt gaggatttct 1419601 tttttgttgt catgagggac atatcttcta agaagattct ggagcgggaa ttctctatga 1419661 atgaacagct ttttaaggac ttgtttgaca gagcagttga cggaatcgtc ctgtttgata 1419721 aagatggcgg ttttattgat gcaaatttgt ccttttgtaa aagctttgaa atcaatcata 1419781 atgagctgtc tcatttatct ttgtatgagt tcatagacag cggctcacga aaagatttcg 1419841 acaatatctg gaaggcgctc aaccgcaagg gaaaagcgaa gggggagctg cctgtcaagc 1419901 ttcgttcagg agttcaaaaa ctatttgaat tcacgattac atcaaacatc atcagcggtt 1419961 tttatatgtc cattatgagg gatatcacag agaagcggtc tatggagctg cagctcttta 1420021 aaagtgagga gcgcttcaga gaaatctttg aaaatgcaat ggacgccatc atcatctggt 1420081 cgaatgacgg aagaatcgta aaagcgaatc aatcagcctg taaaattttt gagctgccga 1420141 tgaatttgct gttgaaaaga aagctgtgtg attttctcgt tgactcgcag cagaaataca 1420201 gcataacgaa gaggaaatac gcaaaatacg gagagatcag agaagagctg ctgtttcaaa 1420261 tggggaacgg ccaattcaaa gagcttgaat ttacttcaaa acggacaatc cttgaaaatc 1420321 agcatttgac gatcttaaga aatgtaagcg acagaaagcg gatggaaaag gagcttcggg 1420381 aaagcgagct gaaattcaga aaagtgttca acggatcaat ggacggcaat gtattgttcg 1420441 acaatcaata caggatcatc gacgccaacc cgttagcaag ccatattttg ggcctgtcac 1420501 atgaagagat caaacagcac agcctgttag atattatttc tgcttatgaa atagaaaatt 1420561 tggcatcacc ggcaaggcag attaattttg atgaaatgga caacgaaatt ccatttttgc 1420621 tgagcagcgg tgataacaga aaactcgaat tctcatttaa acggaatatt attcaaaata 1420681 tgaacttggc tatctttaaa gacgtaacag agcgaaaaga attggaggag cgcctgcgca 1420741 aatcagatac ccttcatgtt gtcggcgaac tcgcagccgg tattgctcat gaaatcagaa 1420801 atccgatgac tgctcttaaa ggcttcattc agcttctgaa agggagtgtc gagggagact 1420861 acgcccttta cttcaacgtg atcacctcag aactaaagcg catcgaatcc atcatcaccg 1420921 aattcttgat tttagccaag ccccaggcca ttatgtatga ggaaaaacat gttacccaaa 1420981 ttatgaggga cacgatagac cttctaaatg cgcaagccaa tctcagcaat gtacaaatgc 1421041 aacttgattt aattgacgac attcccccga tttactgtga accgaatcag ctgaaacagg 1421101 tttttatcaa tatattaaaa aacgccatcg aagtgatgcc tgacggcgga aatatttttg 1421161 taacgataaa ggcattggat caagatcatg ttctaatctc cttaaaagac gagggaatcg 1421221 gaatgacaga agataaatta aagcgacttg gtgaaccgtt ttatacgaca aaggaacggg 1421281 gaactggact tgggcttatg gtaagctata aaattattga agaacatcaa ggcgagatta 1421341 tggtagaaag tgaagaaggg aagggcaccg ttttccatat tacgcttcct gtcagacaga 1421401 atgctgaaga aagaaggaat gatgaatgaa ctactatacg acagccgaaa cgccgctcgg 1421461 tgaacttatc attgccgaag aggaggaccg gatcactcgt ctatttctca gtcaggaaga 1421521 ttgggtggat tggaaagaaa cggttcagaa tactgagcat aaggaaacac ctaatcttgc 1421581 agaagcgaaa caacagcttc aagaatattt cgcaggcgaa aggaagacat tctccctgcc 1421641 gctcagccaa aagggcactc cttttcagca aaaagtgtgg caagcgctgg agaggattcc 1421701 atatggcgaa tcccgaagct atgcggatat tgccgctgct gtcggcagtc cgaaagcggt 1421761 gcgcgctgtc gggcaggcta ataaacgtaa cgacctgccg atttttgtcc cgtgccacag 1421821 agtgatcggc aaaaacagtg cgttaacagg atacgccgga agcaaaacgg agatcaaagc 1421881 atttttgcta aacatcgagc gaatctccta taaagaaaaa taaaacatat ggcacgttcc 1421941 cttttttcac ggccgacata tcattttatt aagttaaaaa agttggtctg atgaaaaagg 1422001 aggacaaagc aattgaagcc gagccgctct gagaaacttg ccgtttttgc cgaactgttt 1422061 gtgaaactgc atatcttatc aagcgctcaa aaagatgaaa tcatcaatgt taacaaaaag 1422121 aaacaaaaaa accgctgact cggctccaaa tgagcaaagt ccagcggttt tttaatgcac 1422181 cttttctcct ttaaacagct gttcaatctc ttcttcatag tttccggtca taatcccttt 1422241 ttctgtgatg attcctgaaa tgagatcatg aggtgtaatg tcgaaagcgg gattaaagac 1422301 aggcacattg gatggagcgg tccgaactcc ggaaatctgc ctgacttcct cgggatctcg 1422361 ttcctctatc gggatatcag cgccgcattt gacctttgta tcaaatgtag ataaaggtgc 1422421 ggcgacaaaa aacggaatat caaaggcgtt tgctaaaata gcaagaccgt atgtgccgat 1422481 tttatttgcc gtatcaccgt tctttgcaat tcggtcggct ccgacgataa cagcggaaat 1422541 ttgtttttcc ttcatcgtat gggcggccat gctgtctgtg atcagagtga catcaatgcc 1422601 cccctgcatc agctcccaag cagtaaggcg tgaaccttgc aggacaggcc ttgtttcaca 1422661 ggcataaatg tgtaatccca aatctttttg tttggccaag taaaacggag ctagcgccgt 1422721 tccatagcgg cttgtcgcga ttgagccggc attgcagatc gtcatgatcc tgtcgccttt 1422781 tttgaaaagc tgcagggcgt tttggccgat caaccggcac gtttcctcat cctcgacctg 1422841 aatctgaatg gcttcatgga caaggtttgt ttttgcttca tttacggaaa tcgcgttttc 1422901 gaccgaatga ctcagtctct caagcgccca tgacaaatta atggcggtag gccgtgagct 1422961 gtttaaatat tgtttgatgt cttccagtct gcggcggaat tccgtgacat tgtctgtttc 1423021 aatgtctttg gcagcaagcg ccagtccgaa ggcagctgta atgccgatcg ccggagcgcc 1423081 ccttactttg agcgtgacaa tcgcatcaaa tacatcctct ttcgtcgtca gctccaaata 1423141 ttccgtctca tcaggaagct tttgctgatt taaaatggta atagctgttt ctttccattc 1423201 aacagaacgt ggaacagcaa atgaatgggt catgaataga tcattccttt acaagtaact 1423261 taaataattc aataacatct gttatcgttt tgaattccga acgtttttcg ataaaggctg 1423321 tgccggtttc gagcgccaag cgttttctgc cgattcgttt atcaaacggc acgatcgtat 1423381 ccaggtcagc tacatgggca aggccgatcg tgcgtcgtat cagctcacag cccgcaaatc 1423441 cgattgcttc ttcaaaaata tggctgagcg tatcagtgag gtaaccgtcg atgttggcgt 1423501 aaacatccag actgtccttc tgccaggctt cactaaacgt ctcttcaaac gtttcccaga 1423561 cctggttgac atgttcatat aacggctctc tgtcagcccc gtcacggctg agtgcgttca 1423621 aaaataagtt ggcgataaat tgccctacat caaagccgat cggtccgtaa aaagcaaact 1423681 caggatcaat cacctttgtt tcgtgctcac ttgcgaaaat gcttcctgta tgcaaatcac 1423741 catgaatcaa cgtttctgca gacgttaaaa atgacttttt cagcttagcg gcttcgattt 1423801 taacgctgtc attattccaa agcttttcga caaaaggacg aagctcttct tcaaaatcat 1423861 ttgtgtcatg gtcgaagaaa ggatctgtaa aaacaagtct ttccgtaatg tcgcatagct 1423921 ctggatttgt aaactgttta acaagctgtt ttttcacctt aggttcaagc gcgtaatctg 1423981 atgagtagaa aagtgttttt cctaaaaatt caccgatgtg ctgcgacaga tgaggatagt 1424041 tttcaccctc aatgagtcct tttcttgcga tcttgaggtg agagagatcc tccatgacgg 1424101 taaccgccat ttccgtatca gaataaaaca ctcttggaac caggtgaggc acatgctcgc 1424161 cctgacggat gagagcgctg ctttcgattc ttgcacggtc gattgtcagc ggccagcttt 1424221 ctcccaccac ttttgcatac ggaaccgcct gtttaatgat caatgctctg tcatgttctt 1424281 gatcataaat atgaaaaacg taatttaagt tgccgtctcc gatctcctgg catgtcagcg 1424341 tgcttttgct tggaaatagg ccaagcttca ccgccaacgc cacagcggag ctttcattta 1424401 acgtttcgta taaaggtgtt tttgtgactc ccatcatcat aacctccaat tatgtaatta 1424461 attaatatgt ggccgtaaaa aagcctcctt ctcagagaga aggaggctta acatctatgt 1424521 ccgcctctct tatctctcag atcagatctg aatggaatta gcaccgtgcc ttaagagacc 1424581 agcgtctcgg cgcgaaaaaa atgcgcccca tttcacaatg gaattacggt cggttgcttt 1424641 tggggtcaaa aggccaaatc cctcgcccaa ctctcgataa gagaatatat tcacttgttt 1424701 gacaattcta atttatcagt tgatgaacat ggtaacaggt aatttagtta gttgtcaata 1424761 tattttttaa tataaatctt ttctgatatc atcgaaaaca ggaatgctct cccgaacttc 1424821 tgcgctttct tgaaggtcga tttccgctcg gactatgcct tcttcccggc cgccttcagc 1424881 aagtacacgt ccccatggat caataatcag gctatgtcct gcaaattcat tatccggatt 1424941 tgaaccggta caattgcagg ctgcgacaaa gcattggttt tcaatggccc gcgcaataag 1425001 caggcttttc caatgatcaa ggcggggaag aggccattcc gcagaaataa acagcacgtt 1425061 ggcgcctttt gtcgtatgtt ttctgatcca ttccggaaaa cggatatcgt aacagatcaa 1425121 tccagagctt ttgacgccgt caagctcaaa gtatccgtct tcggaaccgg ctgataaata 1425181 cagatgctca tccatcagct gaaaaagatg ggcttttctg tactctttaa tgatttgccc 1425241 ttccttatcc gcgatgtaca ttgtattata aacatcagaa ttcttcctga cagcgaccga 1425301 tccggcgaca atatgaacac catgtttttt tgccgttttc ttcagccagc tctgagcgga 1425361 gcggccgtct tcgtcagcga gttcatcaag attggccaga tcatatccgg tcgtccataa 1425421 ttcaggcaga acaagaacat cagcatgttt gctttctttt tcgatgaaaa attcagcctt 1425481 ttttatattt tccgaaggtt ttccgtatga aatatcaaat tgaagacaag atatcgtcca 1425541 tttcatcttt ttaacacccc aaatttttct ttactttttt catttaacca tatatgatga 1425601 tggactatca tttcaagatt tttttagaag gtgagaatag atgaaatttg aacagtctca 1425661 tgtattgaag gaattgccta aacaattctt cgcttctctg gtgcagaaag tgaaccgaaa 1425721 gcttgcagaa ggacatgacg ttatcaatct gggacaggga aatccagatc agccgactcc 1425781 tgagcatatt gttgaggaga tgaaacgagc tgtcgctgat cctgagaatc ataaatattc 1425841 gtcttttcgc ggctcatacc gtctgaagtc agcggctgct gcattttaca aaagagaata 1425901 cggcattgat ctggatccgg aaaccgaagt cgctgtatta ttcggcggaa aagccggtct 1425961 agtcgagctc ccgcaatgct tgttgaatcc cggtgatacg attttagttc ccgatccggg 1426021 ttatcctgat tactggtcgg gtgtcacact tgcaaaagca aagatggaaa tgatgccgct 1426081 cgtaaaggac agagcgtttc tccctgatta cagcagcata accgctgaaa taagggaaca 1426141 ggcgaaattg atgtatttga attatccgaa taatccgact ggagctgttg ctacttccga 1426201 gttctttgaa gataccgtgc gttttgcggc tgaaaacgga atctgcgtcg ttcacgattt 1426261 tgcttacggc gctgtaggat ttgacggctg caagccttta agctttttgc agactgaagg 1426321 tgcgaaggat atcggaattg aaatttacac gctgtcaaaa acgtataata tggcaggatg 1426381 gcgggttggc tttgccgtcg gaaacgcttc ggtcattgaa gcgatcaatc tttatcaaga 1426441 ccatatgttt gtcagtcttt tcagagcgac tcaggaggct gcagcagagg cactgttagc 1426501 cgatcagacg tgtgtggcag agcaaaatgc caggtatgag agcaggagaa acgcttggat 1426561 cacggcatgc cgggaaatcg gctgggatgt aacagctccc gcaggttctt tttttgcatg 1426621 gctgcctgtg cctgaaggct atacttctga gcagttctca gatcttttgc tggaaaaagc 1426681 gaatgtggca gttgcggctg gaaacggctt cggtgaatat ggcgagggct acgtcagagt 1426741 cggactttta acaagtgaag aaagacttaa ggaagccgct tatcgaattg gcaaactgaa 1426801 cctgtttacc caaaaaagca ttgacaagac cttataacga tgggataatt caaaataatt 1426861 tataaaatct atattttctt atcaagagca ggcagaggga cgagcccgat gaagcccggc 1426921 aaccgactta taaagcacgg tgctaattct tgcagctagc ggctgagaga taagattcgg 1426981 acgagaaacg aaacctcttt agacgcgatt gcagtttgaa gaggtttttt gatatggatg 1427041 aaaatgaaag gagctctggc atgagtgagt tattagcgac atatctcctg accgaaccgg 1427101 gagccgatac agagaagaaa gcagaacaaa tcgcaacagg attgacagta ggctcctgga 1427161 ctgatctgcc ccttgtaaaa caggagcaaa tgcaaaagca caaggggcgg gtgataaaag 1427221 ttgaggagag agagggaact gctgcatcag aaaaacaagc ggtcatcaca attgcctatc 1427281 ctgaaatcaa tttctctcag gatattccgg ctttgctgac aacagtgttt ggcaagctgt 1427341 ccctggacgg aaaaatcaaa ttaatcgatc ttcacttctc tgaagcattt aagcgtgcac 1427401 tgccgggacc gaagtttggc gtatacggca tccggaagct gctgggagag tttgagagac 1427461 cgctgttaat gagcatattt aaaggcgtaa tcggaaggga cctgagtgat attaaagaac 1427521 agctccggca gcaggcgctt ggcggagttg acttgattaa agacgatgaa attttctttg 1427581 agactggtct agcgcctttt gaaacaagaa ttgcagaagg aaagcaaata ttgaaagaaa 1427641 cgtatgaaca aaccggacat aaaacgctgt atgcggtgaa tttgaccgga cgtacggctg 1427701 atctgaaaga caaagcgaga cgcgccgccg aattgggagc ggatgcgctt ttgtttaatg 1427761 tcttcgctta cggcttggac gttatgcaag gccttgcaga agatcctgaa atcccagttc 1427821 cgattatggc gcatccagca gtgagcggag cgtttacgtc ttctccgttt tacggttttt 1427881 ctcacgctct tttactcgga aaattaaacc gatattgcgg tgctgacttc agcctctttc 1427941 cgtctccata tggttcggtt gcgcttccaa gagcagatgc actggcgatt catgaagaat 1428001 gtgtgagaga ggatgctttt aaccaaacat ttgctgttcc gtcagcaggc attcatcccg 1428061 gcatggttcc gctattaatg cgtgatttcg gcatagacca cattattaac gccggaggag 1428121 gcgtacatgg acatccgaac ggtgcccaag gcggggggcg agcgttcaga gctattattg 1428181 atgcggtcct agaggcccag ccgattgatg aaaaagccga acaatgcaag gatcttaagc 1428241 ttgcgctaga taaatgggga aaggctgaag ccgtatgacg actcgaaaac cttttattat 1428301 ttgtgatttt gacggaacaa tcacgatgaa cgacaacatt ataaatatca tgaaaacatt 1428361 tgctccccca gagtggatgg cattaaaaga cggcgtactt tccaaaacgc tgtcaatcaa 1428421 ggaaggtgtc gggcggatgt tcggccttct gcccagcagt ttaaaagaag agattacaag 1428481 ttttgtattg gaagatgcaa aaatcaggga aggctttcgg gaatttgtag catttatcaa 1428541 tgagcacgag attccgtttt atgtcataag cggtggaatg gacttttttg tatatccttt 1428601 gcttgaaggc attgtggaga aagaccgcat ttattgcaac catgcttcat ttgacaatga 1428661 ctatatccat attgactggc ctcattcctg caagggcaca tgcagcaatc aatgcgggtg 1428721 ctgtaagccg tcggtcatcc atgaactttc tgaaccgaac caatatatca tcatgatcgg 1428781 tgattcggtt acagatgtgg aggcagcaaa gctgtctgac ctatgctttg caagggatta 1428841 tttattaaac gaatgccggg agcaaaacct caatcatctt ccgtatcaag atttttatga 1428901 gatcagaaag gaaattgaga atgtaaagga ggtacaggaa tggctgcaaa acaagaacgc 1428961 tggcgagagc tcgctgaagt aaaacgggaa ttggcagaga gagattggtt tccggcgact 1429021 agcggcaatc tgtcaattaa ggttacagat gagcctttaa catttctcgt cactgcaagc 1429081 ggaaaagata aacgcaaaga gacggttgaa gattttctgc tggtcgatca aaacggagag 1429141 cctgctgaaa gcgggcattc tctgaaaccg tcagcagaaa cgcttttgca tacacatttg 1429201 tacaataaaa ccaatgccgg atgctgcctg catgtccata cggtaaacaa taatgtgatt 1429261 tcagagttat acggagacca aaagaaaatc acattcaaag gccaggaaat tataaaagca 1429321 ctcggcttgt gggaagagaa cgcagaagtg accgttccga ttatagaaaa tccggcacat 1429381 atcccgacgc tagcggcact gtttgcggaa gagatttcag aagattcagg agctgttctg 1429441 atccgaaatc atggtattac ggcttggggg aaaacagcat ttgaggcaaa aagagtgctt 1429501 gaagcgtatg aatttttgtt cagctaccat ttgaaattga aaacactcga gcatcagctg 1429561 gttaaataaa aggaggaatt gaaatggcta caattcgaat tcatgatgag gcaaatacaa 1429621 cgattgaaaa tcaagaggaa gtggcaagct ttctggacag tcaagaggtt atttatgagc 1429681 aatgggatat cacgaggctt ccggaacatc tctcagagaa atatgacctg acagaagaag 1429741 aaaaacagca aattcttgat accttcgaaa ctgaaattaa agatatctca acccgccgcg 1429801 gctataaagc acaggatgtt atttcattgt cagacagcaa tccgaaactt gatgaactgc 1429861 ttgaaaactt taaaagagag catcaccata cagacgatga ggttcgtttt attgtaagcg 1429921 gacacggtat ttttgtcatt caaggccagg acggcacgtt ttttgatgtc cgtttaaacc 1429981 ctggagattt aatctccgtg cctgagaata tccgccatta cttcacgctt caggaggacc 1430041 gcaaagttgt cgcggtgaga atttttgtca caactgaagg ctgggttcct atttatgaaa 1430101 aagacagcgt gaatcaataa gcgtgagata gccccgttca tcgaacgggg ctttttatat 1430161 ttattgcaaa cgccactttt catattgtga cagttctttt ttaatcagtg tccaaatcaa 1430221 acctaaaaca gctgcatcgt caatgaatcc aagaccgagg attacgtctg gaatgatatc 1430281 gagcggcatg acgatataca ggattgcggc agttaacagc aaaagtgttt taacctgtga 1430341 acgagggtag tcgccatttc gccaatcgcg aagcatctga aaaaaagtag tgatgtgctg 1430401 gatacatttt tttcggtttt tcctctttaa aatcgctttt ccgcctgccg ctccgagcat 1430461 tattgctttc tttttcttca ttgggcatac ctcctgcctg gcggcgtgtt taagatattc 1430521 ttcacctggg tattgttctt ctaatcctat caatatatct attatacctg aaaaattaac 1430581 ttatttaatg aaaatatgtt tacaaataaa gtataatctg taataatgca caataaccca 1430641 atcaaacttg tttcctattt cttagcggcg aggggtgaag tgaatgggcg gttcttctga 1430701 acaagaaaga ttgttggtgt ctattgatga aaaaagaaag ttaatgatag atgccgctag 1430761 aaagcaggga tttacagggc atgacacgat caggcacagt caggagctgg attgtttaat 1430821 aaatgaatat catcagctta tgcaagaaaa cgaacattcc caagggattc aaggccttgt 1430881 aaagaaatta ggcttgtggc cccgcagaga tgttatgcca gcatatgatg caaataaata 1430941 gcggcctatc agatgcatat ataaagagag agcttttcgg aagcgctctt tttttctgga 1431001 aaaaattcat atgaaagagg gaactaatga aggaactggc gattctcatt accgaaatgg 1431061 tcaatcaatt tcatgatgct tttatttcct tatgcggaat atttggcatt catttaactg 1431121 acaaagaaat gcatttttgg gtgatcggca tttttggcat attctttttc ggcgtcactc 1431181 acgctgtgtt tacatggctt tctaaatgga gtatgacagc cttgtccttt atctataccg 1431241 ttacagtcat cattgtcatc gtatttgcga ttgagattca gcaaaaggtg acggggagag 1431301 ggaatatgga gtttttagat gccacggaag gtataaaggg ttttttagta ttttttatgt 1431361 tttttttgct tttgaaaatg ctgttgcgtt tcatcaaaat ccttttttct ggaagaccag 1431421 caagcaaatc gaatggcaat gcccgatcac gaagataaaa aaccctcctg acatggtcag 1431481 gggggctatg atgcggatac ggggagggtg atcgtcacct ctgtgcctct tcgcacttca 1431541 ctttcaatat gaatagagcc tccgtacatc agcacgatcc gtttacaaac aacaaggccg 1431601 agaccggttc ctttttcttt agaagtaaca aagggaagga agatgtgatc cagcatttcc 1431661 tgagaaatcc cttcaccgtt atccacaact ttgattatgg cttttttatc taaagctcct 1431721 agggagatcg tcagtttgcc tccttcaggc attgactcga ggccattttt tgctacattt 1431781 aaaatcactt gtttaatatg atcttttgta cattttacga gtaagggctg ctcggttaga 1431841 tactgtaatt cgacttcaac attgtataga ttgccctcag aataaatgat cggcataatt 1431901 tctccgataa tgtcctgaag tgagttcagc tcccattttt cagctgtcgg cttgccgaga 1431961 acgagaaact cactcactat ttgattgatg cgctttatct cctgttcgat aatggagaag 1432021 taaagctgat cttcctcacc tttatatttc ttttgcaaca gctgaataaa gccgcttatc 1432081 ccggtgaggg ggttacggat ttcatgggct gtgctggcag caagcgtccc gatcagctct 1432141 aatttttgcg cctcgttttc tgagcgctcc agctgggtct gccgcttcag caaataatac 1432201 agcacgagaa taaaaaggat attcagcaga acaataatac atgaaagcgg aagcacaagg 1432261 cttttcgaca gttcttctat tgtgaccggg ttcggataga ctttcatatt ccagctgata 1432321 tcatccagat atccgctgac aggtttctga tcctctgcat gagaggcttg tccgctcgca 1432381 aaaatcattt tcccgtcttg gttcacaact tcaatataaa catcagggct tagtaagtta 1432441 atgagatttt tcaaataatc aatttgaata gctgcgacaa gataatctgt cacattacgt 1432501 tttgagtcca aaacaggcac acaaattgtg aaaattggct gaccagtaat tctgctcgaa 1432561 taactatctg aaatgactgt ctttttagtt tcctttgctt ttataaaaaa agatctgtcg 1432621 gccaggttta ctttcgtttt taattcggtt gtgcttgcgg tgacgtctcc tttggcattg 1432681 agaaaataga gaccggaaaa tctcggctct gaatcaaagg tcttttccaa aattgattgc 1432741 attttcttta tatcaaccgg tctgtcgatg gcgatggaca aggaggtcat tctcgccatt 1432801 gtttctccga ttaaataatt gattttgttg cggtgaaggt ttagcaggac acttgcttct 1432861 tgtttatgtt ctgcagctat tgtatctttt tctttttcat atacgaaaaa gctgatgacg 1432921 attgccggaa tcacgaccag tatgatataa agtttgactc tcccgcaggc gccttttagt 1432981 attttcaatt tgcatcgctc caacatacac ctgattagag gtattatatc attgtttctt 1433041 cttctttaat aagaaaaaat aaccaaaaaa attagaaaaa gatgttggca agcttacatt 1433101 ttaaaaaaga agagaaatat tggaaagatt tttattgaca ttttggtctt tgtttattaa 1433161 tgtttctctg taacggtttc taaaaggatg attgagacat gacagaaaaa tcactgaagt 1433221 tatttatcgt gctgtcgcgc gcgtatcggt ctattaacga tcatatgaat aagcatattc 1433281 ataagcatgg gctgaatccg actgaatttg ctgtgctaga gcttttgtac cataaaggcg 1433341 atcagccgct gcagcagata ggagataaaa ttctcttggc tagcgggagc atcacatacg 1433401 ttgtagataa gctggagcaa aaagaacttc tcattcggaa agcgtctcct acagacagac 1433461 gagtgacatt tgcgcaaatt actgaaaaag gcatcggtct tttgaacgat attttccctg 1433521 atcacgctgc tgaaattgat gaaatgatca gcgtattaag cgaagaagag gtagagatgt 1433581 gcaccgaaat gttaaaaaga gtaggattaa acgcaaaaca gtttcataat aagtaaaaaa 1433641 aggaagcctg atatgtcaca aggcttcctt ttttgctatt tttcatttgt ttccgctgcg 1433701 cctctcggca aaatgagaac ttcaacccgc cggtttttgc ttcggccttc cgcagtttta 1433761 ttggaagcca ccggtttata ctcgccataa cccttggcgc tgaacacttt tgcatcgagc 1433821 ttggggtttt caatcaggag ccccataaag tttaccgctc tcatgacgct taaatgccag 1433881 tttgattgga attcagaatt tttaattggc atattatcag tatgtccgct gataatgata 1433941 tttcttggcg ggttaatcac aagaagattt gaaatctctt ttgcaagcgg cacatcttcc 1434001 ttacggatgg tcgcttttcc agaatcgaag aagatgctgt ctttaatcgt aatcagaagg 1434061 ccttcactag tcatcttcgt ctccagctga tgttccagct ttttatcttt gatgaacttt 1434121 tccacctggc tcttcacatt ttcaagttct tcttgatcag ctgctttttc tttttctttc 1434181 ttgtttttct ctttctcttc tttttccttt ttcacttcat cgatgccgtc tgactcgttt 1434241 tcaggaggag tgacactgga gtagtccagt acaccggttc cgcctgtaaa aacttcatta 1434301 aatgattttg agagcatttg aaacttagct gcgtcaatcg agctgctcgc gtacagcaca 1434361 ataaacaatg ccaggagaag agtaaggatg tcggcgtaag gaacgagcca tgattcatca 1434421 acgtgctcgt cctcatgctt cttcttcttt tttctcgcca ttttgcgcct ctccttgttc 1434481 tgcaaatttc aagcggtcct tcgcaggaag atacattaaa agcttttgtt cgatgacttt 1434541 cggtgcttgt ccttctaaaa cggataaaac accttcaatc atgacctcac gcagttttac 1434601 ttcctgtttt gattttcgtt ttaatttatt tgcgaaagga tgccataaca cataccctgt 1434661 aaagataccg agaagtgtgg caacaaaggc agcactgatg gcgtgtccaa gctcatctgt 1434721 gttatccata tgagagagag cggcaatcag cccgattaca gcgccgagta ctccaagtgt 1434781 cggagcgtac gttcctgctt gtgtaaaaat agcggctcct gcttggtgcc tgtcctccat 1434841 tgcttcgact tcctctgtca taatatctct tataaattcc gcgctttgcc cgtcaacagc 1434901 catgctgagc ccgtttttca agaaagcatc atctacatcc tcaatgcttg cttctaaagc 1434961 aagcagacct tcgcggcgtg caagctgagc ccattcagag aacataggaa tgagttcctc 1435021 tattgtgagc tgtttatttt ccttaaataa cactcgaaac agcgtaggca cttttttaat 1435081 ttcttttgtt gggaacgcaa taacgactgc tgagattgtc ccggcgataa taattaaaat 1435141 ggcagcgggg tttgcaaggg cgctgaaact gacgcctttc agaaccatcc cgacgctcaa 1435201 tgccacaaaa gcaagaataa taccgattaa cgaagtttta tccatagttt tcaccaaatc 1435261 cttttttact agcttgtcta tggttaatat cggttttggt gcccggaact ttagggacat 1435321 tgtgaatttg ttcatgaaat attcaaggaa gaggcataga agggagaaat aaacaaaaac 1435381 gggctctcca aaattgaaaa gcccgggggt ctactgaaat tagcagcttg cttgcaagct 1435441 gtccttcaga tggtattcat ataatagtag aaatacatat tcactgtata taaacatgtt 1435501 ccatccctcc ttaaaaaagt gtaaaggatg aagggaagta gcgcttcagg agaagggacg 1435561 gtaatttcta agtcaagagt atgaaagtat aaaaaaaagc ggcttcctaa aaggaaaccg 1435621 ctgattgtta ttttgctcgc actttgattt tatcatcttc taaaatcacg tgaaaacttg 1435681 tgatctcgcc attatcaagc agcagatcgg tcatttcatc ctcaacccat tcttggatgg 1435741 ttcttctaag cggacgtgca ccgaatgaag ggtggtagcc cagctcagcg attttttctt 1435801 tcgcttcatc tgtcacattc aagctaatgc cccgttccgc caatgtttct tcaagttctc 1435861 caagaagaag gctgacgatt ttgacaagat gttctttttc caatgagcgg aactcaataa 1435921 tgctgtcaaa acggttgagg aactcaggtt taaagaacat gctcagtgaa tcaattaatg 1435981 tttgttcttc gatgacactg tcatctgatt ggaaaccgac tttcgtttgt ttctcaccag 1436041 cacccgcatt acttgtcatg atgatcacag tgtctttgaa gcttacagtt ctgccttggc 1436101 tgtctgtcag acggccatct tccataattt gcaggaacat atgctgaacg tctgggtgtg 1436161 ctttttcaat ctcatccagc aacacaatgc tgtaaggatt gcggcgcacc ttctcagtta 1436221 attgtccagc ttcctcatgg ccgacatatc caggcggtga accgataatt ttagatacgg 1436281 cgtgtttctc catgtattcg ctcatatcga gtcggataat agcgtctttt gtgccgaata 1436341 attcatctgc cagtgtttta gaaagctctg ttttccctac gccggtagga ccgacgaaga 1436401 ggaaggagcc gactggtctg tttttggatt ttaatccggc gcggcttcgt cttaccgctt 1436461 ttgccacttt ttgaacagcg gcttcttgtc cgatcacgcg ttcatgaagt tttgcttcga 1436521 gttctttcat tttcgtttgt tcgtctgcct gcagtttgcc gacagggatg cctgtttttt 1436581 gttcaacaat ttcctgaatg tgctcagctt ccacagtgac agcggtatga gcggaggagc 1436641 tgttcagttt tttctccaat gcgagttctt catcacggag ttttgccgcc agttcgtaat 1436701 tttcttcttc cagggctttt gttttttcgg cttcaattgc agttaagcgt tcagcggcat 1436761 cctcatcatt cagttcatca attaacaggt tggcttttga acctgcttca tctaataaat 1436821 caattgcttt atccggcagg tgtctgtcct gaatgtagcg ggatgataaa gtgacacatg 1436881 ctttgattgc ttcatcactg aatgttacgc catggtacgc ctcgtatttg tctttaatcc 1436941 cttgcagaat gaggatagcc tgttcaattg aaggctcctg caccatgaca ggctgaaaac 1437001 gtctttccag cgcggcatct ttttcgattt gacgatattc tttcagtgtt gtcgcgccaa 1437061 tgacttgcag ttcgcctctg gctagggccg gtttgagaat gttgccggcg tccattgatc 1437121 cttctgcaga gcctgcgccg acgagaaggt gaatttcatc aatgaacaga atgacatttt 1437181 ttcgttcctt cagctcagtg atcagctgtt tcattctctc ctcaaattgg cctctgatcc 1437241 ctgtgtttgc aacaagagat gcaacatcaa gcaagtatag ctctttgttt tttagtttgt 1437301 ttggaacatc accttcagca atttttaaag cgagcccttc agcgatggca gttttcccta 1437361 cacccggctc accaataaga accggattgt ttttgtttcg gcggtttaga atttcgatca 1437421 ctcgcgccac ttcatcatca cggccgatga cgggatcaat gagaccggct tttgcaccgt 1437481 ttgtaatatt ttgagccagc tcatcaagca accctttttt ttcgctttgt tttgctgcgc 1437541 tctgttcttt cggctggaat gcctgttcaa acggaaatcc gaaagattga ggacccatac 1437601 tcattgaagg tttacgggtc agttcgttat agcaagtttc acaaagaacc atctgtttat 1437661 gaacggaatt tatttgcatg ttaaggcgaa tcgtcgcctc gttttgatga caatgttgac 1437721 aacgcatttg ccaaaacctc cttaataatt tgatcatctt tgaccaatga aagtgaataa 1437781 aaaggtctat tgggtttgac cttctttgac tattagtata cggcaaactt aacggcattc 1437841 aaaccaatat gctcaaagca gactgaatat ttgactatct ttgaccaatt gatttttaaa 1437901 aaaggccggt ttgtttgacc aactttgatt aatagtatac tctgactatc tttgactttc 1437961 aagtcttatg cacaaaaatt tttgatttgt tacaaagtaa aacatgtttt cttcgtcttt 1438021 tcaaggaact tgtctcatag gttataaaaa ggcatatatg gacaaaactg cggttcgttc 1438081 ggagggaaga aatggaacaa tcaaaagggt ctgcaagtca gcttgctttt gtgtatgtcg 1438141 gcacagtagt cggagctgga tttgcgactg ggagggaaat tgttgagttt tttctgaagt 1438201 tcggctggtt cggttttttc ggcattctcg tcagcggcgg aatgtttacg ttactggggg 1438261 ccaagctgat gatcatttca aagcgaatca atgccaagtc atatcaagaa atgaacatat 1438321 ttttgttcgg ggcgacggct gggcggatta tcaatgtatt tatgctgttt gttctccttg 1438381 gagttacatc tgttatgctt tcaggggcag gggcgctttt tgaggaacag ctggggatgt 1438441 ccgctcagat tgggatgctc attacaatcg gtctgagttt aattgtgatg actagaggag 1438501 taaaaggcat tttcggtgtc aatgtgtttg ttgttcctct tttaatcatc ttttcaatga 1438561 ttgtggtggc cgactctttt atattcagcg aatcacgaaa cgcagctcag tgggtctggc 1438621 cgcatcgctg ggattggctg ttatcagcag tttcttacgg ggctttaaat ttatcgcttg 1438681 cccaagctgt tttggttccg ctggcgaatg aaatgtcatc ggagaaagtg ataaaaaaag 1438741 gcgctttaat cggaggcacg atgctgacga ttgtgctgtc cgcgagtttt ctgtctttgt 1438801 cgactcttcc ggatgtattt ttgtatgata taccgatggc gcaagtggtt tatctctttg 1438861 cacgatctgt ccatttgatt tatttactca ttattttcgg agaagtgttc acatcagtta 1438921 tcggtaatct atatggatta gaaaaacaag tgcaaagctt tcttccagtg aaaagcaaat 1438981 atatctttgc agccattatg atcacggctt atattacgag ccaaataggg tacggcaggc 1439041 ttatttcaac gatttatccc ttgtttggct atgtgagcct ggccttcata ggcgctttgc 1439101 tttgcaaaaa agctcctcgg cggcgcagtt tataaatata tataatgaaa cgaaccgtca 1439161 ctatagagcg ataattgatc taggaaccgg ggactgactt ttttattgtc aagaaaaaca 1439221 tcattatggt aagatagcag aagtgaaaaa attgaagaaa atccgtgcga tatgcgggag 1439281 aggttctagc tacaccctct ataaaaaact aaggacgagc tgtatccttg gatacggcct 1439341 tttttatgtt tttctagagc accttccgaa aaaaggtgtt tttttgcgtg aattagctgt 1439401 agcgatgtct ctcgccggcg tttttattgc ggagaaggag aggaatcatg aaaaaagaaa 1439461 aagcaattgt cgtatttagc ggcggtcaag acagcacaac atgcttactg tgggccttaa 1439521 aagaattcga agaagtcgaa acggtgactt ttcattataa tcagcgacat tcgcaggaag 1439581 ttgaagtggc aaaatccatt gcggaaaagc ttggtgtgaa aaatcatttg cttgatatgt 1439641 cacttttaaa tcagcttgca ccgaatgccc tgactagaaa tgatattgag atagaagtaa 1439701 aagacggcga actgccatcc acattcgttc caggccgcaa tttggtattc ttatcctttg 1439761 cgtctatcct ggcttaccaa attggcgcgc gccacattat tacaggagtt tgcgagacag 1439821 acttcagtgg ttatcctgac tgccgtgacg aattcgtgaa atcttgcaat gtcacggtaa 1439881 atctggcaat ggagaagccg tttgtgatcc acacgcctct catgtggctc aataaggcgg 1439941 aaacgtggaa gcttgcagat gagcttggcg cgctggattt tgtgaaaaac aacacgctga 1440001 catgctataa cggcatcatc gcagacggct gcggcgaatg tccggcatgt caccttcgtt 1440061 caaaaggtta tgaagaatat atggtgatga aaggagagcg tgcataaatt gttatctcaa 1440121 atttatccgc aggcccagca tccttattcg tttgaactga ataaggacat gcatatctca 1440181 gccgctcatt ttatccctcg ggaaagtgcg ggagcgtgca gcagggttca cgggcatacg 1440241 tataccgtaa atataaccgt tgccggcgac gaacttgacg attcaggctt tcttgtcaat 1440301 ttcagcgtac tcaaaaaact ggtgcacgga aactatgatc acacgctatt aaatgatcat 1440361 gaagattttt ctcaggacga ccggtattcg ctgccgacaa ctgaagtcgt ggcgaaaacg 1440421 atttatgaca acgtacaggc ttatttagac actttggaga ataagccgac ctgtgtacag 1440481 gtgtttgtcc gtgaaacacc gacaagctac tgtgtctacc gtccgaaaaa gggtggtttg 1440541 aatggctaaa ggaattcctg tattagaaat tttcggcccg acgattcaag gagaaggcat 1440601 ggtgatcgga cagaaaacga tgttcgtccg gacagccggc tgcgattatt cctgcagctg 1440661 gtgtgactcc gctttcactt gggacgggtc tgctaaaaaa gatattcgct ggatgacggc 1440721 ggaggagatt tttgcggagc ttaaggacat tgggggagat gcgttttctc atgtgacgat 1440781 ctcaggcggc aacccggctc tgttaaaaca gctggatgct tttattgaac tgctgaagga 1440841 aaataacatc cgtgcagcgc ttgaaactca agggaccgtt tatcaggatt ggtttacgct 1440901 gattgatgac ctgacaattt ctccaaaacc gccaagctca aaaatggtaa cgaactttca 1440961 aaagcttgac cacattttaa cttcacttca agagaatgat agacagcatg ctgtcagctt 1441021 gaaggttgtc atctttaatg atgaagatct ggaatttgcc aaaactgtgc acaagcggta 1441081 tccgggaatc ccgttttatt tacaagtcgg aaatgatgac gtgcatacga cagatgatca 1441141 gtcactgatt gcacatttgc ttggaaaata tgaagcgctt gttgataagg tagctgtcga 1441201 tgcggagctg aatctcgtca gagtgctccc gcagctgcac accctgttat ggggcaacaa 1441261 acgcggagta taatagaaag gaagatgaac atgacgacaa gaaaagaatc agaattagaa 1441321 ggtgtaacat tgctaggcaa tcaaggtaca aattatttgt tcgaatatgc accggacgtg 1441381 ctggaatcct tccctaataa acatgtaaac cgtgattact ttgtaaaatt caattgcccg 1441441 gaattcacat ctttatgtcc taaaacaggc cagcctgact ttgcgacaat ctacatcagc 1441501 tacattcctg atgaaaaaat ggttgaaagc aaatcattaa agctgtatct attcagcttc 1441561 agaaaccatg gtgacttcca cgaggactgc atgaatatca tcatgaacga cttgattgaa 1441621 ttaatggacc cgcgctacat tgaagtatgg ggcaaattca cgccaagagg cggaatttcc 1441681 attgatccgt acacaaacta cggaaagcct ggcacgaagt atgagaaaat ggccgaatac 1441741 cgtatgatga accatgattt gtatccggag acaattgata atcgttaatt attccgttgt 1441801 gtgatacgga gtgtaaaagg aagtggagtc acagtaaaat ccgaacattc agcgttaatt 1441861 ttcagcggaa atgtgacctg gtcacagcga agtgtgaccc gcactaagct caataaaagt 1441921 gggaaaagtc acacctgaaa atggctctac tcatgggaat tgtattaaaa agtgtgacct 1441981 gaggtgcaac ctgaactgtg acttttatgc agtgaaaaat tgatagtaca gaagcagatt 1442041 aaggcgtaca atttgtacgt cttttctttt ttatccgaaa gaaaaaatgc ctatctagag 1442101 atcataggca ttaaatatta ttatcaatat cttcatttat tttttggcta agtttctgaa 1442161 ccttctcttt aacatttgaa acagctcttt tttgaatttc atcaattctc ctgaatatag 1442221 tcgatgacac ttcttattag aacttcactt tcaaaattga atatctcatt tatttctgac 1442281 tgttcttcat ctgttaggtg atggtattga agttgtttag catttacttc agcagctaca 1442341 tcaatcctaa cttagttgtt ctggttgtac aatttcatat tcaccttctg catactcttg 1442401 ctccgcataa tagcctcccc attgacagag ctcctgcaag ataggtttaa gagattctcc 1442461 aagttcagtg gatgaatatt caaccttcgg cggtacttga ttatacatct ttctgctcac 1442521 aagtccactg gcttcaagct ctctaagtgt ttgaatcagc attttctgag ttatatttgg 1442581 gataatgcgc tttaattcac tcgttctctt tggtccattc attaaaaagt ataatacaag 1442641 gcctttccat tttccgccaa taacttcctt tgtcacttca aacccacagc taaatttttt 1442701 catgtctaaa gctctccatt ccacatttat tactttttag ttactatatc acaaaaaagt 1442761 gggtacttcc gataatgtgc ttactgaagg atactatatc ttgtaagttg ttcttcaagt 1442821 acttaaaggt actagacata aaataaaatt aattctaaag gagtgttaag tatgggtaaa 1442881 tttgaaggta aaatagcgct tgtaacgggt ggaacaagtg ggattggtct tgctacagca 1442941 caaaaatttg taaacgaagg tgcatatgtt tatattacgg gacgtagaca aaacgaactt 1443001 gataaagctg ttaaccaaat tggcaagaac gtaaccggtg ttcaaggtga tatttctaag 1443061 cttgaagact tagacaaact atatgacatt ataaagcagg aaaaaggtaa gttggacatt 1443121 ctttttgcta atgcaggcat cggcaacttc cttccattag gtgaaattac tgaagagcag 1443181 gttgatagaa cgttcgacat taacgttaaa ggaaccatct ttactgttca aaaagcgtta 1443241 tcactattcc cggacaaagt aggttctatt attgtaacgg gctctactgc tggatcaatt 1443301 ggcaacccag cgtttagtgt atatggagca tctaaagcag cattaagagc actagttcgc 1443361 aactggattc ttgacctaaa aggtactgaa atccgtgtaa atgtggttag tccaggaggt 1443421 attcttacac ctgcctacga tgagcttttt ggtgatgcac ttgaagaggt actggaaaat 1443481 agcagaaata ctgttccagc tggaaaagtt gggacacctg aagaagtagc aaacgctgta 1443541 tctttccttg cttcagacga aagcagttac ttgacgggtg ttgaattgtt cgtagatggc 1443601 gggctagcac aggtataatt tcactgcgca gagattacaa atagtcccca aaaaaggtta 1443661 atggggattt acttgaagaa gtcgtataaa aaagtcgttt tccttaaagg acagggaatt 1443721 cgactttttt atatttgaat ttgattaacg ttgtaaattc gcattttcct ggggctacta 1443781 ctaaatgacc tgtaaaaaag attacactgt gaataaatgt acttaaagta acgggggctc 1443841 ttgactttta ataaaaaata atatccctgt ccttgtattc taatactttt aaaaatattt 1443901 aaaggaatcc ttatgtcctg aataaccaca taggaaaata tgttgtaggt tgctttcttt 1443961 ttttgtgggg catcccacac aagctatctc gtgatctcac acctgaacgt tttttataga 1444021 ctagtaccgc gacaagttat attacatata cataccaata aagtagacat taaaaagtga 1444081 aagagaggat ggaaatgtgt gaaaattctt ttccttgaga gtcatcccat gtggctctat 1444141 ggtttaccga atgggtttag ggaagcagga cataccgtaa tgatttccgg tcctgtaagt 1444201 cgggaaaata taactgaaat gatagacgaa tttaaaccag atttaatagt atctatggga 1444261 tggacaccag agcattcaag ggaaaagcag gcctggattc gcaacgctac taaaaaggtg 1444321 aatatccctc tcgtttattg ggcaactgaa gacccgctgc acactcaaaa ctttactatc 1444381 ccgttaatta aaaagatgaa accggatttt gttttcacgg tcacgccttc tctgtgtaaa 1444441 acttatgaaa gcatggggat taaagcagct cacttagact ttgcatttca cgaaagtata 1444501 catcaccaga ttaaaccatt agcgaaatac agttgtgata tagcagtggt ggctaatgct 1444561 taccctaatt ttcttgaaga acatccggaa gtgttccgtt cgtcctcttt aaaaacgctt 1444621 attcgtcctc ttatacggaa gggtattcgc attgattttt gggggagaaa ctgggaaaaa 1444681 atgagtaaat atataggaag agaaattccc cgcaattgga tccatggata ccttgattat 1444741 actgaagcat ataaagttta cagttcagca aaaatcatta tcggtttgca aaactgtgaa 1444801 agccaactta cacaacgcac ctatgagatt cttggttccg gggggttttt attgacatcg 1444861 gatacaccag cagttcgagg taaattcaaa cctggccgcg atctcatcgt ttcttcctcc 1444921 ccaaaagaaa cattggaaaa ggttaaatac tatttaaatc atgatagcga gagaaaaaag 1444981 attcagataa acggtaaaaa ggctgtaaag aatgattcct atcggcatag agccgagaga 1445041 atgcttgagg tgctaaaaag cagaggaatc ataagaaact taggggaaac cattcattat 1445101 gtagatgttc tcaaagaaaa atacgtgatc catcatgtta ctcccggtga aacattatca 1445161 ataattgcca gtaagtataa tgtttccctg cagcaactca tggagcttaa tcatttcaaa 1445221 tcagatcaaa tatatgctgg acaaatcatt aagattagag agaaactgtt tagaaatatt 1445281 aataacaaat tattctaaag gagagtaata tgaatgaagg ggaaaatacc taaaataaga 1445341 aatcaagcga ataaagtaaa aagaacgcct cgttatatgg aatttcccgt gacatacgaa 1445401 gtatatcatg tggaatccgg cgatacatta tggacgattg ccaaatcctt tgaaattccg 1445461 gtacaacaac ttatgaatct taataagctt tcttcagata gaatttatcc tggacaaatt 1445521 ataaagataa gagaaagata atctttgagg tttcggaagc gaatcaaatt gaaatgacaa 1445581 tcctcatttt tttatttgtg gggaacttga tatttttggg gatgaagggg ttatgagatg 1445641 tttcaaatga gctattacta ttctggatta ggatgggact ttattcaaca cgttgatcaa 1445701 acgaacggag tattaaatgt tgtgtctcct gattttttct atatcagaaa agatggatca 1445761 ttacttctcc gttcagctaa tcccgatgtg attaaagctc ttcatagaag aaaattaaaa 1445821 gtagttcctt ttctaagcaa tcattgggat caggatttgg gacgatttgc attaatgaac 1445881 cgagttcttt tagctaaaca aatttctcat gcaatagaag aactggattt ggatggagtt 1445941 aatatcgata tagaaaacct tacagaaaaa gatcggaatc tatttacaga ttttattaga 1446001 ttagtaagga aaagtattcc tagacataaa gaagtatcag ttgcagtggc ggcaaatcct 1446061 tttggctgga cgaagggctg gcacggatca tatgattacg agtatttagc taaatatgca 1446121 gattatctta tggttatggc ctatgatgaa agccgccttg ctgggcctac tgcaagtgta 1446181 ggatgggtgg aaaagtccat tcaatatgtt ctgacccaaa aaatctctcc tcaaaaacta 1446241 gttttaggat tgccattcta tggccgctgc tggatggaag gccaatctgc ctctcaagcc 1446301 attccccttt accttgttgt tagtaaaaag gcatagcggg acaattattt ttgacaccaa 1446361 gagtcaatct ccaaaagcta tttttactgt caatcacgat aaaaaggggc cgttgccttc 1446421 gggaacatat acattatggt ttgaaaatga acagtcactc agagcaaaaa taaaactcgc 1446481 tcaaaaatat aatctgaaag gtcttggcag ctggagtctt ggacaagaag atgcgtcagt 1446541 ctggaataca gtgtttaaaa atatataatg atttatagtt cagaacaaaa ttcgaagata 1446601 attgcaatga atctctaaat ggacatactg aaaggagttt attacgagtg cgggtaaaac 1446661 agtgagggca ttccataggc ccttctccca aaatgttcta cacgaggcat tacattgggc 1446721 ttgaaataca cattcaaact tatgttatag tacgcatttt acggatgtgt tgaatttatt 1446781 ctgcttccat gatttaatca tacacatgct acttgatagc agggttatcg catttcattc 1446841 agaattgttc aggatcgata tggaagcgca cgactaacta gaactttaaa agcatacact 1446901 catatacttc ctgaatggat gctggtttat ctaaaaaaca tgatgagaat tgattgtacg 1446961 catggtgaag catgacttgt tgataatcga ccatatggtt tctccttaga aatgaggggg 1447021 tttttacata aaaaagacga gcgaatccgg ggggaattcc actcgccgct ttctaatgaa 1447081 aagacgggat gctggatggc agctcgtctg ttttattata atttaacgaa cgtatgtttg 1447141 taaaggtgtc ttttcgaatg aattggttca tataaccgtt aagaacagat tcattgtaaa 1447201 cattcgctaa ggtatgctaa gatgcatgga ctataaagga gtgatatgaa gtgaagacat 1447261 tgcggttaaa caatgtaacg ttagaaatgg ctgcatatca agaggagagc gagccgaagc 1447321 gaaaaattgc atttacctta aacgttacga gtgagactta ccatgatatc gctgtcctgt 1447381 tgtatgaaaa aacgtttaat gtcgaggttc cggaacgcga tcttgccttc cggggggaaa 1447441 tgacaaatta ttcaacatca ttgaccaacc tgtacgaacc aggggccgtc agcgagttct 1447501 atatagaaat aacggaaata gacaaaaacg ccgattcatg atcggtgttt tttatgtaaa 1447561 aaagctgccg gccggcagct tttgagaaag cgaatttcat atgtaaggtg ttaaattgtc 1447621 cgtcttgcag ttttttgaat aaatgtggaa ataaggaggt tttaatagga gtctctgatg 1447681 atcttataat ttttatgatt aacaactgtc aatgaatcta actcaagatc ccgatagtta 1447741 tccatgatcg tcacatcaac gataacagaa ttctcattta ctttttcaac aacaccggtt 1447801 aatccgtttt taaattcaat gacattccca accttagcga ttttcacaag cttcctctcc 1447861 tttaaacata ataatgcctt ttgaaagtat tttgcagtat tttcattgag aagtaaagcg 1447921 ataaggagtt ttatctccct tatgaattgt tctgtcgcta taaagatgat atattgattt 1447981 tcgtcaatag aaagaaaagg ggggaatttt tgttgcgtcc cgaagaaata acagaaatga 1448041 ttgaacagct gcgcaccggc gccataaacg aactgagagt ccagaaagag cattttcttg 1448101 atttcagggc cgtgttatct aaacaagatg attttaaaca tttccgagga attgcccagc 1448161 aaggcggaga tgttatcttt caatacttag aacagccaag aagctgaagg tttctcatac 1448221 gtgagaagcc tttttatcat atatgacaga acacaagcct tttattacag ctgtctgtaa 1448281 caggtgtaaa taaaatgtaa agtaccaaag atggataaac atgttttaat ttaacaatat 1448341 ttatagaatt tcagactgtt tttttgccat taagcagtga gtcatcctct ttattccatc 1448401 ctgatacctc cttgggagag ttggaaaatc tttttccgtg aaaatgaatg gatctcttgt 1448461 taaggttatg aagtgttttt tggagcactt taaggaggaa actgtatgac aacgaaattc 1448521 actgctctgg ctgtttttct tctttgtttc atgcctgcag ccaaaattga gcatacacaa 1448581 gcttcactac tgagcgcaaa gaagacaaaa catgaagaag cgaaatggct tacacatata 1448641 gatcgaaata cgaatgaatc tttcccttca ctgtctgctg ataaagacaa gaaaataaaa 1448701 ccgattaagc tatcagcaca cactgaaaag aaagagaaag ataaaccgga caaaacaaat 1448761 gatgagaaag aaacatatac acagtctgaa aaagagttgc tgtcccgtct cgttcacgca 1448821 gaggccaaag gagaatcata taaaggcaag gtcgctgtag caagcgttgt actgaacagg 1448881 acggagaaaa aaggttttcc tgatacgata agaggagtta tttatcagaa aaacgccttt 1448941 gaaccggtcg caaacgggag cattaaccaa aagcctgata aagaatcgat tgaagctgcc 1449001 gaagaagcgc tgtcctcaaa aaatagagaa acagatgcca tattctttta taatccgaaa 1449061 acagcgtcag ataattggat tcgttcaaga aaaatcgtag aaaaaatcgg cagacacgtt 1449121 tttgccgtct aagcatagaa gagacaattt gtctcagctg tgcttttttt catataaaga 1449181 gtaaaaataa aataattttt gaacttgtct catatgatgt tggtagtaca agagacaagg 1449241 agagacatca tgaatcgatt tgtgaaaggg atcattcttt tatccattgc cgcctttttc 1449301 gctgaatgcc ttgaatttgt cgtcaatatg attttggcgc gggagcttgg cgagcatggg 1449361 atggggcttt acatgagtat tttgcccacg atctttttaa ttattgtcat cgcgagcctg 1449421 gaactgccga tatccatttc taaattcatt gccgagtcaa atcctaagct tcatgaaagc 1449481 atgctgaggc acgctttcag aatgacagcc atttttactg ctttttctac tgccgccgct 1449541 agtattgcgc ttccgtttat tccggtattt gatacatacc acccgtttat taaagggatt 1449601 gtcatcggct taattcctgt tgtcgccttt acttcaatcg ccaggggcta ctttatgggt 1449661 gtgcagaaaa tggggaagat cgcaattgcc aatgtgctga aaaaaatcat ccagctcttg 1449721 tgcttattcc tcttttttca atggtactca tttgaattgg acatggctgt gctgatttcc 1449781 ttgtttgttc tagtcgtgag tgatgtggtc gtgcttgttt atttatattc acaatttatc 1449841 atggcaaggc gggcgttatc cggccagcag cacattcatt tgcgcggaaa ggatgtaagg 1449901 aaaagactgc ttgctgtttc aattcctaca acaggactgc gtatttttca tgcggttgtc 1449961 aatgcaattg aacccttttt agtaaaagga gctcttttgg ctgcgggcgt tgccgggaca 1450021 gcggcgatcg atcaatacgg aatgctggca ggagtggctg tgacgatagg gtcgttccct 1450081 gcttttattg cccattcgtt aatggtcgtc atgataccga gtatttcgga agcttatgca 1450141 ctttctcagt atgacatcgt gttaaaaagg ctgaagcagt cgattttcat tacattaggt 1450201 tacggtatac ctgccgtctg ggtcatgttc cagtttgcgg gacctctcac gcatttgttt 1450261 tttcactctc ctgaagcgca gtattacttg cagctgttgt ggccttactt tctctttcat 1450321 ctgtttgtca tgccgctgca ggcgtgctta atcgggatgg gttttgtgaa agaggctttt 1450381 tatcacaatg tatggagcca tatcgttgcg ctaagtatga tgtatgtact gggatcaatg 1450441 gagaatctgc aaatgctcgg gattatcctt ggaatgaaca ctggcatgat tcttttgacg 1450501 agcctgcact atgccacgat ctgcaaagca ttgaaggtat ctgtatttct tacgggaggg 1450561 accagaacgc cgcgaattga aggatgataa aggaacagca ggggcaagct aattgaaaag 1450621 catgaaagga agattccatg ttgacgaagc gcttgcttac tatatacatt atgttattag 1450681 ggttgattgc atggtttcca ggtgcggcac aagctgagga aaaacagcct gctgttcccg 1450741 ctgtttttct tatgaaaacg atagaagggg aggacatctc gattccgaat aaagggcaaa 1450801 aaacaattct ccatttttgg acgtcatggt gcccgccctg caaaaaggag cttccacagt 1450861 ttcaatcgtt ttatgatgcc catccatccg acagtgtaaa gctggtaacg gtgaatttag 1450921 tgaattcgga acaaaatcag caagtcgttg aagactttat taaagcaaac aagctgacgt 1450981 ttccgattgt ccttgactca aaaggggaat tgatgaagga gtatcatatc atcacgatcc 1451041 caacatcatt tttgctgaat gaaaagggag aaattgaaaa aacaaaaatt ggcccgatga 1451101 cagcggaaca actgaaggaa tggacggaag aatagctgag agcatagact ctcagctttt 1451161 ttcatataga gaagaagtga ataaacatta atgataatta ttatcaaaaa gaaattaaaa 1451221 taattataat tgaaattctc ttcgtgcgtg ctataataaa ggaagacatc aagaaataac 1451281 tgacgataaa gctgcctttt gggcagcgat tttgttttta taagagaaat gaagatgatt 1451341 tacgttctca attagagagg agaattcgat atgaatgaac aagttatcgt tcaacgcgac 1451401 ccgcatgagc cattgaaaac agacaagagg gaaaaaaact gggcacagca cgcggagctt 1451461 attgcagcac ttgtatcagg cgctcttatt ttggcaggct ggctcttatc cggatatcag 1451521 gtattatcca taatactttt cttgctggct tttgtgatcg gcggatttgc taaagcgaag 1451581 gaaggaatcg aagaaacact cgaatccaaa acgctgaatg tagaactttt aatgattttc 1451641 gctgccattg gttccgcctt gatcggatac tgggcagagg gtgctatttt aatatttatt 1451701 ttttccttaa gcggagcttt agaaacatac acgatgaata aaagcagcag agatttaacg 1451761 tctttaatgc agcttgagcc tgaagaagcg acattgatgg tcaatggtga aaccaaaaga 1451821 gttccggttt cagacttgca ggccggtgat atgattgtga tcaaacctgg agaacgcgta 1451881 gcggcagacg gtatcattga atcgggctcg acaagtcttg acgagtcggc tttaacaggt 1451941 gaatcaatgc ctgtagaaaa aaacacaggc gacactgtat tcacaggaac ggtgaatcgc 1452001 aatggctcct tgacagtccg tgtcacgaaa gcaaatgaag attcgttatt cagaaaaatt 1452061 atcaaactgg ttgaatcagc gcaaaatagt gtttcacccg cgcaggcttt catcgaacga 1452121 tttgaaaatg cttatgtgaa aggtgtgcta attgcggtgg cgctcctttt attcgtcccg 1452181 cactttgcgc tgggctggag ctggagtgaa accttctacc gcgcaatggt gtttatggtt 1452241 gtcgcgtcac cttgtgcgct tgtcgcctct attatgccgg cggcgctgtc cctgatttca 1452301 aatggcgccc gcaacggtat gcttgtgaaa ggaagcgtct ttcttgaaca gctgggctca 1452361 gtgcaaatga tcgcctttga taaaaccgga actgtaacaa aaggccagcc tgccgtagag 1452421 acgatcagaa tagcagaagg attcagtgaa gcggaagttc ttgaggctgt ctatgccatc 1452481 gaaacgcaat caagccatcc gctcgcccaa gccataacgg cgtacgctga aagccgcggc 1452541 gtgaatcagt ccggctacat atctatagaa gaaacctcag ggtttggcgt tatggcagaa 1452601 gtgtcgggtg cgaaatggaa ggtcggtaaa gcaggtttta tcggcgagga aatggcagca 1452661 caatttatga aacaaacagc atcagatgtc attcaaagcg gtcatacaat tgtatttgtg 1452721 aaaaaggatg atcaaatagc aggctgtatc gcactgaagg accaaatcag gcctgaagca 1452781 aaagaggtca tggaagaact gaaccgactt gggattaaaa cggccatgct gacaggagat 1452841 cacgaagaca cggctcaagc gattgccaag gaagccggca tgacaactgt cgtggcagaa 1452901 tgcctgcctg accaaaaagt gaatgaaatc aaacggttaa aagaagaatt cggaacgatt 1452961 gcaatggtgg gtgacggaat caatgatgcg ccggcactca aagcagcgga tgtcggcatt 1453021 gcgatgggcg gcggaacaga tgtagcactt gagaccgctg atatggtcct catgaaaaac 1453081 gatttgaaaa agctcgtaaa catgtgccgc ttgtctcgga aaatgaacag gatcatcaaa 1453141 caaaatatcg tgttttctct agctgtaatc tgcctgctga tttgtgcaaa ctttttgcag 1453201 gcgatggaat tgccatttgg cgtgattggt catgagggca gcacgatttt agtcatacta 1453261 aacggtttaa gactcctaaa ataaaaccag cagcctaatc aggctgctgg ctttttatgt 1453321 atcaagcttt cccttcattt ttgtctttat cagatctttt cataactagg atgagagcga 1453381 gggtgcagca aaggaaaccc gctgcacagc ctatgataga gctgtaataa taaaagccca 1453441 ccatcttcat cccgataaaa ggagcggaaa ttcccaaaac cgttaagagc ataactgctt 1453501 ttcgtctgaa aaaattcatc agcaaacgga acaacccccc tgcgattgaa cgttactgtc 1453561 agtatacagg aagaggagca ggaaataaaa tgcattagaa aatgaaggcg tcgtgaaagg 1453621 caaacaccgg taaaacctgt tacaatggaa gacagaacaa tgcattgcaa atggcaggga 1453681 ggaacaagaa gtgaatagaa tacaacgcgt ctcttcatgg ctgaaggaag cggggcatac 1453741 tgccgcattt attcatacga aagaaaatgt tttttactta accggttttt acacagagcc 1453801 gcatgaaaga ttaatggggt tatttatttt tcaagaagag gagcctttct ttgtttgtcc 1453861 aggaatggaa gcaggacagg cccgcaacgc aggctggaat catgaaatca ttggctatgc 1453921 ggatcacgaa aatccgtggg agctgataga gaaggctttg aaaaagcgaa atatcagcat 1453981 acatatgctt gcggtagaaa aggattcaat ctcgctgtca cgtgcagaac agctgaagca 1454041 tgcgacgggc ggggctcaat ttgtttcagc agaagaaaca ctcaatcaat ttcgcctgat 1454101 taaagatgac aatgagattc gtttgctgaa agaggcggca aagcttgcag attacggtgt 1454161 tgaagtcggc acagccgctt tgcgtgaagg catcagtgaa gtggaagtgc tcgctcaaat 1454221 tgagtatgag ctgaagaaaa aaggaattca gggcatgtct ttctctacaa tggttttatt 1454281 cggagaaaaa tctggccagc ctcatggaaa tcctggtaca gccacgttga agaaaggtga 1454341 ttttgtttta tttgatctcg gtgttattct tgatggctat tgctctgata ttacaagaac 1454401 gtttgcatac aaaaccatca atccgaagca ggaggccatt tacgagactg tgcttcaagc 1454461 ggaaaaagcc gcgattgagg caagcaaacc cggtgtgaga atcggagatc tggatttaac 1454521 tgcccgcgga atcattgaaa aagcgggata tggtgattat tttcctcacc ggcttgggca 1454581 tggactcgga atttcagtcc atgagtatcc atcaatgagc caggccaacg atacactgct 1454641 gcaggaaggc atggtctaca cgatcgaacc ggggatttat gtgccagaga tcggcggcgt 1454701 acgcattgag gatgacgttc acgtaacaaa ggacggagca gttgctctga cccaatatcc 1454761 aaaggatttg atcatactgt aatagaaata aaaaaggact ttgttctcga catcgtcctt 1454821 ttttatctgc attaaataaa aaaatcatca aatgttcgaa agggtttaat ttcatgtttt 1454881 tggttgagag gttttacagc aagacagctg ccaccgagaa cagtgagaca taacccaatt 1454941 aaaatgaaga aacccatgtg atcttctcct ttcagctaaa aacacaaaaa gatatctggt 1455001 acgtccatat catattgtat gaaacgcatt ccagatcaag gggatttaga aagaagggaa 1455061 tctatggcta atattaaaga cattgcagag aaagccggtg tctctgttac aacggtttcc 1455121 cgagtcataa acaatcatcc atacgtcagt gaagacaaac gaaaaagagt gtttgaggca 1455181 atggaatcat tggagtacac gagaaatatt cacgctgtac atttgtcgaa aggattttca 1455241 aacatgattg gtgttgtctt gccgacggtt aatctgccat attttgcaga gctgattgca 1455301 ggaatagccg acgcagccgc ggaatccggg gttcacctct ctttattcca aacaaactat 1455361 gaagtacaaa aagaaatctt tgcgctgtcc caattaaagc agcgccaggt tgacggcctg 1455421 attttttgct caaaggcgct tgctgatgag aaactcatgg aatgggaggg cccgattttg 1455481 ctttgccaga attcagataa tgcccgcttc ccaaccatca gcattcctca ccaagaagca 1455541 tttcggaacg gcttggacta tttaattgcc aaagggcaca aaaaaatagc catctgtttg 1455601 gcaagaaaaa aaggcatgaa cagccatttt cgaatcaaag cctacaaaga ggcattggaa 1455661 gagatcggcg aggcatttcg tgaagactgg gtaattgaga aagcgattac aatcaatgat 1455721 gggaaggcgc tttttcataa atggaatacg tggaaggaaa agccgacggc tatttttgtt 1455781 gccaatgacc aagtctcagc agggcttttt cttgaagcaa agaaccagcg ggtgtcagta 1455841 ccggatgagc ttgcaatctt aagcgttgat aaccacgaaa tcagccaagc gcttggaatc 1455901 acaacgatcg atattcagac aagggaaatg ggaaagcagg catttgccat attggaaaaa 1455961 agaattcaag gacagccgat tgaaaggaaa gttctggatt accgtctcat cgaaagatcg 1456021 actgtttagt gaatgcattg aaaaaaggtt tgacgtgcat tctgttcgtt atgtacgata 1456081 tgaggtattg aatgacaaag gagctgagga tcgtgaatgg gtccttcaca gtgaaaaagg 1456141 tactgaataa taacgtatta attgcttctc atcataaata cagcgaagtc gttttaatcg 1456201 gaaaaggtat tggtttcgga aaaaaacaag atgatgtcat tgaagataaa ggctacgata 1456261 aaatgttcat tttaaaagac gagaaggaac aaaagcagtt taaaaagctc cttgactatg 1456321 ttgatgaaaa gctcgttgat atttcaaacg atgtcatcta tcacataagc aataggacga 1456381 atcactcatt aaatgaacat attcacattg cgttgacaga ccatatcgca tttgcgatca 1456441 aaaggcagca gcagggattt gatatgaaaa atccatttct aatggagact cagtcactat 1456501 atcctgagga gtaccaaatt gccaaagaag tcatagatat gatcaatgaa aaagcgggac 1456561 tctgccttcc ggaaggggag attggtttta tcgctctgca tatccattca gcgttgacaa 1456621 accgtccgct gtccgaggtc aatcagcact ctcagctcat ggcgcagctt gtcgaggtga 1456681 ttgaagactc atttcaaatg aaagtaaata aggaaagtgt caactatttg cggctgatca 1456741 ggcatatcag atttacaata gaaagaatta aaaaagaaga accgactaaa gaaccagaaa 1456801 aattaatgtt gttattgaaa aatgaatatc cgctatgcta caatacagct tggaaattga 1456861 ttaaaatctt gcagcaaaca ttgaagaaac cagttcatga ggcggaagcg gtttatctga 1456921 cgcttcatct gtaccgatta accaataaaa tttcataaat tcagtttatc cttataacgt 1456981 gttactgatt cgatcaggca tgagtgattg agggaaaaaa acgggaagtt cattctcgtt 1457041 cttttgcgca cccaattttg ctcatgcctt tttgttgtgt aaaagggcaa atgtaaacgg 1457101 ttaaactgga agacttacgc ctgtgaattc gttgtcatga tttttagctg taaggtcaga 1457161 ctagtaaaaa gaggaggtca attcttatgt ttaaagcatt attcggcgtt cttcaaaaaa 1457221 ttgggcgtgc gcttatgctt ccagttgcga tccttccggc tgcgggtatt ttgcttgcga 1457281 tcgggaatgc gatgcaaaat aaggacatga ttcaggtcct gcatttcttg agcaatgaca 1457341 atgttcagct tgtagcaggt gtgatggaaa gtgctgggca gattgttttc gataaccttc 1457401 cgcttctttt cgcagtaggt gtagccatcg ggcttgccaa tggtgatgga gttgcaggga 1457461 ttgcagcaat tatcggttat cttgtaatga atgtatccat gagtgcggtt cttcttgcaa 1457521 acggaaccat tccttcggat tcagttgaaa gagccaagtt ctttacggaa aaccatcctg 1457581 catatgtaaa catgcttggt atacctacct tggcgacagg ggtgttcggc ggtattatcg 1457641 tcggtgtgtt agctgcatta ttgtttaaca gattttacac aattgaactg ccgcaatacc 1457701 ttggtttctt tgcgggtaaa cgtttcgttc caattgttac gtcaatttct gcactgattc 1457761 tgggtcttat tatgttagtg atctggcctc caatccagca tggattgaat gccttttcaa 1457821 caggattagt ggaagcgaat ccaacccttg ctgcatttat cttcggggtg attgaacgtt 1457881 cgcttatccc attcggattg caccatattt tctattcacc gttctggtat gaattcttca 1457941 gctataagag tgcagcagga gaaatcatcc gcggggatca gcgtatcttt atggcgcaga 1458001 ttaaagacgg cgtacagtta acggcaggta cgttcatgac aggtaaatat ccatttatga 1458061 tgttcggtct gcctgctgcg gcgcttgcca tttatcatga agcaaaaccg caaaacaaaa 1458121 aactcgttgc aggtattatg ggttcagcgg ccttgacatc tttcttaacg gggatcacag 1458181 agccattgga attttctttc ttattcgttg ctccagtcct gtttgcgatt cactgtttgt 1458241 ttgcgggact ttcattcatg gtcatgcagc tgttgaatgt taagattggt atgacattct 1458301 ccggcggttt aattgactac ttcctattcg gtattttacc aaaccggacg gcatggtggc 1458361 ttgtcatccc tgtcggctta gggttagcgg tcatttacta ctttggattc cgatttgcca 1458421 tccgcaaatt taatctgaaa acacctggac gcgaggatgc tgcggaagaa acagcagcac 1458481 ctgggaaaac aggtgaagca ggagatcttc cttatgagat tctgcaggca atgggtgacc 1458541 aggaaaacat caaacacctt gatgcttgta tcactcgtct gcgtgtgact gtaaacgatc 1458601 agaaaaaggt tgataaagac cgtctgaaac agcttggcgc ttccggagtg ctggaagtcg 1458661 gcaacaacat tcaggctatt ttcggaccgc gttctgacgg gttaaaaaca caaatgcaag 1458721 acattattgc gggacgcaag cctagacctg agccgaaaac atctgctcaa gaggaagtag 1458781 gccagcaggt tgaggaagtg attgcagaac cgctgcaaaa tgaaatcggc gaggaagttt 1458841 tcgtttctcc gattaccggg gaaattcacc caattacgga tgttcctgac caagtcttct 1458901 cagggaaaat gatgggtgac ggttttgcga ttctcccttc tgaaggaatt gtcgtatcac 1458961 cggttcgcgg aaaaattctc aatgtgttcc cgacaaaaca tgcgatcggc ctgcaatccg 1459021 acggcggaag agaaatttta atccactttg gtattgatac cgtcagcctg aagggcgaag 1459081 gatttacgtc tttcgtatca gaaggagacc gcgttgagcc tggacaaaaa cttcttgaag 1459141 ttgatctgga tgcagtcaaa ccgaatgtac catctctcat gacaccgatt gtatttacaa 1459201 accttgctga aggagaaaca gtcagcatta aagcaagcgg ttcagtcaac agagaacaag 1459261 aagatattgt gaagattgaa aaataagggt gttagtacgc cgtgcttgtc agatgacaag 1459321 tacggttgta tgatataata ttgtgaagta ataaagcttt aagttaaaag gagaatgata 1459381 aaaatggcac aaaaaacatt taaagtaact gcagattctg gaatccatgc tcgtcctgcg 1459441 acagttcttg tacaaactgc tagcaaatac gacgctgacg ttaatttaga atataacggc 1459501 aaaacagtta accttaaatc tattatgggt gttatgtctt taggtatcgc taaaggcgct 1459561 gagatcacaa tctctgcttc cggagctgac gaaaacgatg ctcttaacgc tttagaagaa 1459621 acaatgaaaa gcgaaggact cggcgagtaa tgcaagaatt aaaagggatt ggtgcttcag 1459681 ccggcatcgc gattgcaaaa gcgtaccggc ttgaagagcc agatttaacg gttgaaaaga 1459741 aaaacatctc tgattctgaa gcggaagtaa gccgttttga tgaagcgatt gcacgttcaa 1459801 aagaagagct cgaaaaaatc aaagagcacg ctttgaaaga actgggtcag gataaagctg 1459861 atattttttc tgctcacctt ttagttctca gtgaccctga gcttctgaac cctgtgaaag 1459921 aaaaaatcag cactgattca gtgaacgctg aattcgcttt aaaagaaacg tcttctatgt 1459981 tcgttactat gtttgaatct atggacaacg aatatatgaa agagcgtgcg gcagatatcc 1460041 gcgatgtaac aaaacgcgta accggccacc tgcttggcgt cgaaattcca aacccaagca 1460101 tgatctcaga agaggttatt attgtagctg aagacttaac accgtctgac acagctcaat 1460161 taaaccgtga gttcgtaaaa ggattcacta ctgatatcgg cggacgcaca tctcactctg 1460221 ccatcatggc acgttctctt gagattccag cagttgttgg aacgaaagct gctacaggca 1460281 cgatccaaaa cggcgtgact gttatcgttg acggtatcaa tggcgatgtc attattgacc 1460341 catctgcgga aactgtaaaa gagtatgaag aaaaacataa tgcttatttg gctcaaaaag 1460401 ctgagtgggc gaagcttgtc aatgaaccga ctgtctcaaa agacggacat catgtagagc 1460461 ttgcagcgaa catcggtact cctgatgatg taaaaggtgt tcttgaaaac ggcggagaag 1460521 cagttggcct ttaccgtaca gaattccttt acatgggaag agatcagctg cctacagaag 1460581 atgagcagtt tgatgcttac aaaacggttc ttgagcgtat ggaaggaaaa tcagtcgtcg 1460641 tgcggacact tgatatcggc ggagacaaag agcttcctta cctgcagctt cctaaagaaa 1460701 tgaacccgtt cctgggatat agagcgattc gtctttgcct tgaagagcaa gaaatcttca 1460761 gaacacagct tcgcgcgctg cttcgtgcaa gtacatacgg aaacttgaaa atcatgttcc 1460821 ctatgattgc gacagttaac gaattcaaag aagcaaaagc gatccttctt gaagagaaag 1460881 aaaagctcgt aaaagcggga caggctgtat ctgacgatat tgaagtcgga atgatggttg 1460941 agattccgtc aactgcagtc atcgctgatc agtttgctaa agaggttgat ttcttcagta 1461001 tcggaacaaa cgatttgatt caatacacaa tggcagctga ccgtatgaat gaacgtgtat 1461061 cttacctgta tcagccatac aacccggcaa tccttcgctt aattacactg gtaattgaag 1461121 cagcacacaa agaaggaaaa tgggttggca tgtgcggaga aatggcagga gacgagattg 1461181 cgattccgat ccttctcggc ttaggcttag atgagttctc aatgagcgca acgtctatcc 1461241 ttccggcaag aacacaaatc agcaaattgt ctaaacaaga agctgagtca ttcaaagaga 1461301 aaatcttatc tatgagcacg acagaagaag ttgtcgcgtt cgtaaaagaa acattcaagt 1461361 aatgtacaaa aaccagacgg cctccggcct gtctggtttt tttcataagt aagggtatag 1461421 aaggacacaa taacatggct aggagggata gtatgtcaaa ccaatttaac gcaggagata 1461481 ctgtttatgt gatctacaga aatccgcacg ccgccaatgt agcccacata aaggaagccg 1461541 aaattgtgca ccatccatac catgaaggcg agctttccct gtttatttat gaaacctatc 1461601 atccattcgc agaggacgat gctgtgtttg caagctatga agaagctaaa tcgctttaca 1461661 aagaactgtt tgatattgat ccgtatgagt aacaaggaaa tcattacaac tcatatcctt 1461721 tccgcctagt gagaaaagta acgttagtaa aggaaaagga tgtggcatca tgcagaaccc 1461781 atttgttccg cagcttgtgt atatagaacc gagggcgctg gaatatccgc tgggccaaga 1461841 attacaagat aaatttgaga atatgggtat tgaaatcaga gaaacgacat cccacaatca 1461901 ggtgcgtaat atccctggga aaaatcatct tcagcaatat cgcaatgcga aatcaacttt 1461961 agttatcggt gtccggaaaa cattaaagtt tgattcatcc aaaccctcgg ccgaatatgc 1462021 cattccgttt gcaacaggct gcatggggca ttgtcattac tgctacctgc aaacaaccat 1462081 gggatcaaag ccgtatatca gaacttatgt aaacgtcgaa gagattttag atcaggcaga 1462141 taagtatatg aaggagcgcg caccagagtt cacaaggttc gaagcatcat gtacgtcaga 1462201 cattgtagga attgatcatc tgacacacac gctgaagcgc gccattgaac attttggcca 1462261 aagtgatctc ggaaagctcc gatttgtaac gaaatttcat catgtcgatc acctattaga 1462321 cgcaaagcat aacgggaaaa cgagattcag attcagtatt aatgccgact atgtgattaa 1462381 aaactttgag ccgggaactt cacctcttga taagcggata gaagcggcag taaaagttgc 1462441 aaaagcaggc tacccgctag gctttattgt tgctccgatt tatattcatg aaggctggga 1462501 agaaggatac agacatctgt ttgaaaagct agatgctgct ttgccgcagg acgttagaca 1462561 tgacattacg tttgaattaa ttcaacaccg ttttacaaaa ccggccaaac gagtgataga 1462621 gaaaaattat ccgaagacga agctcgaatt agatgaagaa aagcgccgtt ataaatgggg 1462681 ccgttacggg atcggaaaat atatttatca gaaagatgaa gagcatgcac ttcgagaggc 1462741 acttgaatcc tatattgata cctttttccc taacgcaaaa attgaatatt tcacttaaac 1462801 gggctgttgt gatcaacagc tcgctttttt ataaaaaaca tttttccatt ccatcaaaac 1462861 gccgtaattc aatgattctt tatcctccaa ataattgctg actacacgaa taggtgaacg 1462921 cccgcaacgg aggagaaagg acagcacagg gtcgtttttc ctgccttcca tcacatcttc 1462981 aacgtactga acagcgctga tctcgtgtgc gtatttataa tacaaaggaa tgcggccgcc 1463041 gccgagaagg cgttccagtc ttttatcaac agtcagctca tacatcgtat tcatcagcca 1463101 ttttccgatt ccaagctttc gataatgagg agaaacagaa atatccacta catataaagt 1463161 atttccatga ggttcatgat ttttaatcga tccgttgtca gttgcttgtg cccatgtatg 1463221 atcaggagaa tcaggctcaa attgtacaat aagagcagtc atggaaccga taattctgcc 1463281 attgatgagc gcgcataaag cgccttccgg aaaggttttg atatggctgg caagctggtc 1463341 ctctgaccac agcaattcct ggggaaacgg aggagggaaa cattcttctt gaagagaaat 1463401 cagcctctcg atgtcagtct cagtgtagtt tctaatggtc agagcctcaa attttctgcc 1463461 gtcatgcaca tacatttgtt ttagtatgat catcactctc cttatgttgt ttcattataa 1463521 cgaagattga attttcagta aatatattcc gattttctta taatttattt tttgattatt 1463581 catttttcaa acgaaagggc cgatatagaa attaggaggg gattggtttg tttaaaaaac 1463641 ttcacatgaa gattgctgtt tttgtttcga ttatgttaat catcacagtt gttctcttaa 1463701 tgctgtcttc ttatttgacg ctaaaaccga tgattacaga ggatgggaaa aatacaactc 1463761 aaaacgtgac gcagtcactt gaacaaaata ttgaattgca attaaagagt tatgccattt 1463821 cgttatcaag attggctaat ggggaattaa cgcatacatt tgtaacgaaa ccaagtaaag 1463881 aagcttctcg gctgtttcac gatgacatta agcaaatcaa agacaacgat gattatgttg 1463941 cgatggctta cataggcacc gcaaaaaaag aaatgtttac atatccaaaa gcggatttcg 1464001 ctgaggatta cgatccaaca tcaagaccat ggtataagct tgcagctgaa accccggatc 1464061 aagttgtttg gacggaacct tataaagatg tcgtgacagg agacatgatt gttactgcat 1464121 cgaaagcgat cttagacagg caaaaagtga taggggttgc cagctatgac ttgaaactct 1464181 ctgctatcca gagtatggtc aataaacaaa aggtgcctta caaaggattt gcctttttag 1464241 ctgatgcgag cggcaatctt ttagcccatc cgtcaaatca aggaaaaaat atatcaaagg 1464301 atcaaacact gcaaaccatc gcatccgaga aaaaagggat acaagatgtg aatgggaaaa 1464361 tggttgtgta ccaaacgatt ggcgagacag gctggaaggt cggaacgcaa tttgataccg 1464421 atcaattaat gtggatttca gataaaatga atcgggccaa tctttggata tcattgattg 1464481 cgcttatcat aacaattatt ctcagctact tcctggccaa aacgataacc ggtccgatac 1464541 agcagctgat cgtaaaaacg aaagctgttt ccgcaggcga tttaacagtg cgcgcggaat 1464601 caaaatctaa ggatgaagtc ggtattttaa caagagattt caatctgatg gttgaaaata 1464661 tgaaggaaat ggttgagcaa gtgagactct cttcagggaa agtatctgac acctctgaac 1464721 aactaacggc tgtggctgcc gaaactaatg aaacaagcgg acaaattgca aaagcgattg 1464781 aagaagtagc cgcaggggca tcggaacagg cttctgaagt tgaaaccatt aatgaaaaat 1464841 cggaaagcct gtcaacgaaa atcaggcaaa tcgctgagga ggcaggcgga attaaagaac 1464901 gctcaaaatc gtccgaggat gcaagctata aaggacttga cgcgctcggc cagctgctga 1464961 tgaaatcaaa cgaagccaat atggaaacga aaaaggttga aacgatgctg ctggatttgg 1465021 aaaatcaaac taagaatatt gaagaagtcg ttacagcgat ttcaaacata tctgatcaaa 1465081 ccaacttgct tgccttaaat gccagtattg aggcagccag agccggagaa agcgggcgcg 1465141 gttttgccgt cgtagccgat gaagtgcgga agttagctga gcaatcagcc ctttctacaa 1465201 agcatatcag cgagactgtg aagcttatcc agcttgagac aaaagaggcc tctcacgcga 1465261 tggttgaggc aagcagaatg aatgatgaac aaaacagtgc aattcacgaa actggagagg 1465321 tattaaatac gataactgca gaaatgcagt cactggtaca aggtattgat cacatttacg 1465381 cggaaattca aagaatgagt gaagaacagc ttgcgatttc tgaagccatt caaagcattt 1465441 cagccatatc acaggaatca gctgccgcag cagaggaagt gaacgcatca accgatgaac 1465501 agcttgtcac ccttgataaa gtcaaacact caacggaaac actaaaacat gcaagccaag 1465561 agcttatgaa cacaattgca aaattcacat tgtaatccaa ttacatcccc aaacatcatt 1465621 tgttttgggg attttttatt ttataagatg aatagatatg gtagtctaga aaatgaagga 1465681 aaaatgataa attttaacta aaatctaaac gaaacatctg ggaggaatga ccttgaaaaa 1465741 aacaattggt tttatcggtc ttggagtaat gggaaaaagc atggcatcac atattctcaa 1465801 tgacggccat cctgtattgg tgtacacccg gacaaaagaa aaagcagaaa gcatacttca 1465861 aaaaggcgcg atctggaaag atacggtcaa agatctttcg aaagaagcgg atgttatcat 1465921 cacaatggtc ggctatccca gtgatgttga agaagtgtat ttcggaagca atggaattat 1465981 tgaaaacgca aaagaaggtg catatcttat tgatatgacg acatctaagc cttcgcttgc 1466041 gaagaagatt gctgaagcgg ccaaagaaaa agcattgttc gctttagacg ctcctgtttc 1466101 cggtggagac atcggtgcac aaaacggaac actcgcgatt atggtcggtg gagaaaaaga 1466161 agcttttgaa gcctgcatgc cgattttctc tttaatggga gagaatattc agtatcaagg 1466221 accggctgga agcggacagc ataccaagat gtgcaatcag attgcaattg cagccggtat 1466281 gatcggtgtt gctgaagcga tggcttatgc ccaaaaatca ggcctagagc cggaaaatgt 1466341 tctgaaaagc atcacaacgg gcgcagccgg aagctggtca ttgtcaaatc ttgctccccg 1466401 tatgctgcaa ggcaactttg aaccgggatt ttatgtgaag cattttatta aggatatggg 1466461 aattgcacta gaggaagcag aattaatggg ggaagaaatg ccaggcttgt cgctcgcaaa 1466521 atctttatat gacaagctag ctgctcaagg tgaagaaaac agcggaacac agagtatata 1466581 taagctttgg gtgaaataaa aaaagattgc ctgtacgaaa caggcaatct ttttttatta 1466641 ttttccgatg aattgttgtg tccagatgct tccagactca acgtaaccaa caccgatgtg 1466701 agtaaagtta gggtttagaa tgttttttct gtgtccttca ctgttcatcc aagcttttac 1466761 tacttcttct ggtgtctttt ggcccttcgc aatgttttca cctgctgttt tgtagctgat 1466821 tccgaaagat ttcatcatat caaacggtga gccgtatgtt gggctttggt gatcaaagta 1466881 gtttttgtct ttcatatcct gagattttgc gcgtgcagat ttgcttaacg tttcatcaat 1466941 ttgaagcggt tttaagcctt gtttttgtct ttctgcattt gtaagttcaa caactttttt 1467001 ctcatatgca cttacagatg aaggtgcaga cgttgttgtg tttgtttttt cagcagttgc 1467061 gggtgcttta gaagcagtgt tttgatcagc agctgctttt tcagtagtct tttgtgcagg 1467121 ttttgccgtt tctgtctttt gaacatcctg aactttcacg ttagattgct tcgcatgttt 1467181 ttgaagaagc tgcttcatct ctttttcgtt tgcagcgttt aacgttttga tatttgtgtt 1467241 aatatgcagt tttttcactg catcgttaag tgacatgttt tgtactgtgt tccccgtttt 1467301 tactgtaacc acaggctggc aggagagttc tttcgctgat gcttgctgta cgcccccgaa 1467361 tgtgaataat ccaaccgcag cggcagcaga taaaataaat gctttcttca ttagttcgta 1467421 acctcctaga gttgtttgtt tctacagaaa aatcataaca tagctttttt gtcataaaga 1467481 ttccagcact ttcctttgac aaatagagat tgtcattttc gtaaagtaaa tccgttgaat 1467541 cactaagaat aagggaatca gcggtatata tgattttatc gtaccgttac atagcttcct 1467601 tttttttgaa ccgttagtta tattttaatg tgtttttata ttgacagctt tttttactcc 1467661 ttttcgctgt aacaactatt acaaaggtgt tacaattaat ctcagtatat gtaaatatat 1467721 tgaatgattt gagaggggta accagaagtg actgaaatag gacgtgaacc aaagaaaaag 1467781 agcaaaggaa acagagcaat cagaatgaac ctttttttcc tagctgtctt tgttctattc 1467841 actgcattaa tttttaagct cggggttgtt caaattgttg aaggcgaaca gcatgaagaa 1467901 gacgctgaga aatcaaatgc aaaaacagct tactatcctg cgcctcgcgg gaagatgtac 1467961 gacagaaacc agaaagttgc tgtcgacaac cagagcgttc cagaaattgt gtatgtatca 1468021 acatctagca caaaaacaga agataaaatc aaaacagcga agcggcttgc ttctttcatt 1468081 catattgata ccgaattttt gaaggaaagg gatcttcgtg attactggat cgcagctcat 1468141 ccgaaaaaag ccgccgctct gcttaaggaa tcagaaagca atctgaaagg agaccaggct 1468201 tacaagcttc aaatagagcg tgttccggat caagaattaa aggctattca gcaagatgac 1468261 gaagaaatgg aaactgctgc gatatataca aggttttcaa gcggaaatgc ttacgaacct 1468321 caaatcgtaa aggcaatgaa tccaaataag agcaatagca atggaaaaaa cggagcgctg 1468381 cttgatgaga agaaaaactc ctcgcaaaga ccaaaaaatg acttaacata tgatgaaatt 1468441 tccattgttt ctgagcattt agaagaactt ccgggaatcg atatcgtaaa cgattggaca 1468501 cgaaaatatc cttatgacaa aaccctttat tctgttttcg ggggcgtcac gacacctgat 1468561 cagggcctgc tgagcgaccg gaaagatttc tacttaacaa gaggctatgc gaataatgac 1468621 agggtgggaa aaagttattt agagtatcaa tatgaagaat atttaaattc gcataaagaa 1468681 aaagtggaat acgtagaaga taataaagga aatgtcgtca gccaaaaaac cattgataag 1468741 ggcagcaggg gatacgatct tcagctttct tttgacatgg agcttcaggc aaaggtagaa 1468801 aagatcattg aagaagaagt aagaaacagc cgtgcacgcg gaaattacat gcttgacaga 1468861 gcctttgccg taatgatgga cccgaataac ggcgatattt tatcaatggc agggaaaaag 1468921 atagatttaa aaaccaacaa aattgaagat tatgcgatag gggcatttac cacccaatat 1468981 gaaatgggat cagcagtaaa gggggccacc gtgctagccg gctatcagga cgggatcccg 1469041 cattataaat attatatcga tgctccaatg cttttaggaa cgaatcttat aaaaaaatct 1469101 tatactaata tgggaaccat caatgaatta accgcattgc aaaaaagttc aaacgtatat 1469161 atgttcaatg ttgccatgca tattgcaggc gtaacataca agccgcatgg atctctcccg 1469221 gctgatcaga acgatctact gaaaatgaga aactattaca gccagtttgg tctgggagta 1469281 aagacaggta ttgatctccc gcaggaatca gccggaatgc aaaccacacc taaaactgta 1469341 ggaggattaa ttttagactt agcaattggc caatacgata catacacacc gcttcaaatg 1469401 gctcaataca tctcagtaat cgccaatggt ggctatcgtg ttcagcctag aatcgtcaca 1469461 agtattcata agccaggaaa aaaagaccag ctgggtaagg cgattgaaca taggaaacct 1469521 aaagtactca ataagattaa taattcagag agcgatttga aacaagtaca aacaggcatg 1469581 aaattagtca cttcttcagg gacagcaaaa aatacgttta cagaagatgt atcagggaaa 1469641 acgggaacag cggaaacatt ttactacggc acgaatcgca actggtgggg gaaaaaaaca 1469701 tacaatctga cttttgtcgg ctattacccg tcgaaaaaac caaaagtggc ctttagtgtt 1469761 gttgttccat cagtagatga tgatgataag atcaataaaa ttattgccaa aagagctatc 1469821 cacgcctacg cagagctcga aaaaaaacac agtaaaaaat aaaaaacagg gtgcacaact 1469881 aaaagattgt gtgccctttc ttttattcaa aaattgacgt tcaccataag aatagaagga 1469941 gaatactcat tttctagcga atcatactag gtaaaagtca atctgtatat gtcgaaacac 1470001 gatgatcatg caaaggaggg attctgtgga acaggatacg cagcatgtta aaccacttca 1470061 aacaaaaacc gatattcatg cagtcttggc ctctaatgga cgcatcattt atatatctgc 1470121 caactccaaa ctgcatttgg gctatctcca aggagagatg atcggatcat tcctcaaaac 1470181 gtttctgcat gaggaagacc aatttttggt tgaaagctat ttttataatg aacatcatct 1470241 gatgccgtgc acctttcgtt ttattaaaaa agatcatacg attgtgtggg tggaggctgc 1470301 ggtagaaatt gttacgacaa gagctgagcg gacagaacgg gaaatcattt tgaaaatgaa 1470361 ggttcttgaa gaagaaacag gccatcaatc cctaaactgc gaaaaacatg aaatcgaacc 1470421 tgcaagcccg gaatcgacta catatataac ggatgattat gaacggttgg ttgaaaatct 1470481 cccgagtccg ctatgcatca gtgtcaaagg caagatcgtc tatgtaaaca gcgcgatgct 1470541 ttcaatgctg ggagccaaaa gcaaggatgc tattattggt aaatcgtcct atgaatttat 1470601 tgaagaagaa tatcatgata tcgtgaaaaa caggattata cgaatgcaaa aaggaatgga 1470661 agtcggaatg attgaacaga cgtggaaaag gcttgatggc acacctgttc atttagaagt 1470721 gaaagcatcc ccgaccgtct acaaaaacca gcaggctgag ctgctgctgc tgatcgatat 1470781 ctcttcaagg aaaaaattcc aaaccatcct gcaaaaaagc cgtgaacgat atcagctgct 1470841 gattcaaaat tccattgata ccattgcggt gattcacaat ggaaaatggg tatttatgaa 1470901 tgaatcggga atttccctgt ttgaagcggc tacatatgag gatttaattg gcaaaaacat 1470961 atacgatcag ctgcatcctt gcgatcacga ggatgtaaaa gagagaatcc aaaacattgc 1471021 cgagcaaaaa acagaatctg aaattgtcaa gcaatcctgg ttcacctttc agaacagggt 1471081 catctatacg gagatggtct gcattccgac gacctttttt ggtgaagcgg ccgtccaggt 1471141 cattcttcgg gacatctcag agagaaaaca aacagaagaa ttgatgctga aatcggaaaa 1471201 attatcaatc gcagggcagc tcgcggcggg aatcgcccat gagatccgca accctcttac 1471261 agcgatcaaa ggatttttac agctgatgaa accgacaatg gaaggcaacg aacattactt 1471321 tgatattgtg ttttctgaac tcagccgtat cgaattaata ctcagtgaac tgctcatgct 1471381 ggcgaaacct cagcaaaatg ctgtcaaaga atatttgaac ttgaaaaaat taattggtga 1471441 ggtttcagcc ctgttagaaa cgcaggcgaa tttaaatggc atttttatca gaacaagtta 1471501 tgaaaaagac agcatttata taaacgggga tcaaaaccaa ttaaagcagg tattcattaa 1471561 tttaatcaaa aatgcagttg aatcaatgcc tgatggggga acagtagaca ttatcataac 1471621 cgaagatgag cattctgttc atgttactgt caaagacgaa ggggaaggta tacctgaaaa 1471681 ggtactaaac cggattggag agccattttt aacaacaaaa gaaaaaggta cggggcttgg 1471741 attaatggtg acatttaata tcattgaaaa ccatcaggga gttatacatg tggacagcca 1471801 tcctgaaaaa ggcacagcgt ttaaaatttc atttccaaaa aaataaaaac aacggcttaa 1471861 acgccgttgt ttatcgtctg cattgcttca cgttttttta atacaaataa ttctaaacgg 1471921 tctaggcctt ctctcagcgt gtccattgag catgcaaaag acagccttac atatccttca 1471981 ccatatgttg agaacgagct gcccggcacg agtgccacgc cagcgtcttc caaaagagcc 1472041 atactaaaat caaatgaagt cattccaaat gatttaatag aagggaagat ataaaacgca 1472101 ccggacggtt taactacgtc aagtcccatg gaaacaagac ggtcataaac atagtccaga 1472161 cgttttttgt attgttctct cataatcaat gcatcgtcaa agccgtttgt gacagcttca 1472221 agcgcggctt tttgagaaat ggatgaggcg cacgacacat tgtattgatg aacctttaaa 1472281 atgtgctttg caatgtcttt cggtgcaaat aaaaatccaa ttctccaacc ggtcatgctg 1472341 tgtgattttg acaacccgtt aatgacaatc gtttgatccc gcaaataggt tgcgatggag 1472401 taatgcggtc tgtcatatgt taattcactg tatatttcat cagacaatac gaagacattt 1472461 ctgcctttta agagagctgc gatgcttttc agttcttctt cagataaagt cacgccggta 1472521 gggtttgacg gataaggaag cacgacacac ttggtgttgg gtgtcagagc atcttcaatc 1472581 agccgggcgg taagcttaaa gccgtgtgac gtagtatcaa caatgacagg cttggccccg 1472641 cacaaattga taataggttc atagcccgga taaataggcc ctggcataat gacttcatca 1472701 ccgggagata aaatcgtccg gaatgcagca tcaatggctt ggcttgcgcc tgttgtgatg 1472761 ataatttcag attcagcatc atagttgaaa tccgcttttt tcttcatata aagctgcaca 1472821 gcttgtctca gctccaggta gccggcattc ggagtatatg acgtcacgtt ttcatcaatg 1472881 gctttttttg cggcagcttt cacatgatgc ggtgtgaaaa aatcaggctg gccgattgta 1472941 agtgaaatga cgtcttcgtg ttgggctaca agattcgaga atttgcgtat tcctgaaatt 1473001 tcgatctctc ttgctttcgg attcagcaaa tgttccataa ttcatcacct taacaaatat 1473061 aatgagttta tcctatttta ccactagctg atcatttgtc acctttttaa ctgatatatt 1473121 tcgattgtat gcgccttttt tctaaacata cctttctttt cagaaaaaaa gaagacaacc 1473181 agcgatttga ttgtctttat tgtatcatgt tctattattg tttatatgtg ccaatttcat 1473241 taatagccat aatcaaaatg aaggtcttcg tgccaaatca gatacggagg atgctcttct 1473301 tgaaggtcag ctgattcttt cttcatattc aggtaagttt cttcactgat atcctctaaa 1473361 acagtcattt cgttttcttt aaatattact aaggtaccca ttatttacac ccttctttgg 1473421 aaaaatcctt gactatttta tcactgttag ttggaaagtc aatggttatt aggaaaaaag 1473481 tttctttttt gaggaacgcg gcttgttgcc ttcggaattc gattttgaag agctgccatt 1473541 cactttttac aaattacgcc gatatataca gtacaatact gaatgcgaat agcgagggat 1473601 tgaattgtcg ttacaacaat acgaaatttt attggattct ggtacaaatg aattagaaat 1473661 tgtgaagttt ggcgtgggtg aaaatgcttt cggaattaac gtcatgaagg taagagaaat 1473721 tattcagcct gtcgaggtga catcagtgcc tcactcccat cagcatgtag aaggaatgat 1473781 taaactcaga ggagaaatcc tccctgtgat cagtctcttc tcattttttg gagtagagcc 1473841 tgaaggatca aaagatgaga aatatatcgt gactgaattt aataaacgga aaattgtttt 1473901 tcatgtcggc tctgtttctc aaattcacag agtatcctgg gaagcgattg aaaagccgac 1473961 atcgttaaat caaggaatgg agcggcacct taccggtatt attaagctcg aagacctgat 1474021 gatctttttg cctgactatg aaaaaattat ttatgacatt gaatcagatt caggtgttga 1474081 cacgtataat atgcataccg agggcttcga tgaaagaaga actgataaaa agcttatcat 1474141 tgtagaggac tcaccgcttt tgatgcgcct cttgcaggat gaattaaaag aagcagggta 1474201 caacaatatc gcttcgtttg aaaatggaaa agaggcatat gaatacatta tgaaccttgc 1474261 tgaaaacgaa actgatttat caaaacagat tgatatgatc atcactgata ttgaaatgcc 1474321 aaaaatggac ggacacaggc tcacaaagct gctgaaggaa aatccgaaaa gctcagatgt 1474381 gccggttatg attttctcat cgttaattac ggatgatctg cgtcaccgcg gcgaagttgt 1474441 aggcgcagat gagcaaatca gcaagcctga gatcagtgat ttgattaaaa aagtggatac 1474501 gtatgttatt gaataaataa aaacagccgt tgccagaaag aggcacggct gtttttattt 1474561 taaaagtaac tctcgccaag ttttttaaag accggtttat ggtaagctgg ctgctggcga 1474621 tttggcacta gcggcttttc tttcatgccg acatattctt gcaataggtg tttcgctttt 1474681 gttaaagaca tttgagcttt aggatttcga tacgattgat taagtgtacc taaatgcgga 1474741 agatgttcga agtcttcttt agttggaggc atgtgaaaat agtagtctcc gattgagata 1474801 agcacgtccg attgctgttg gctgaacctt ggattttttg aaaaatgaag ccctattttc 1474861 tttcctttac cttctttgac aagcttttgc aaagcccgtt ttttcagcag atataggtat 1474921 ttagggttgg gggcggtttt tgcatggcgg ttcacagtgt aaactgcttt tgaaagattt 1474981 tctacggttg gctgcagatc tttcgtatat gcatggtcgt ccattatttc tctcctttgc 1475041 tcttatcaat ttctatatgt ttagattata cttttttaaa gttgaaatgc aaatattgaa 1475101 tgtaaaaatg cgcttttttc taagaaaaaa agcgcatttt taacctgcat tatacagatc 1475161 ttgccttctt tttcggctgt tcttgaaatg cttcctgaac attcacttcc acagcctgag 1475221 cactgtattt tggcagtgca ataaaataaa aaataaaaac gagcaggata ataacaccca 1475281 tgccgtaata aagataatca atgtttgaaa caaacttagg gaataacagc gcgactaagc 1475341 cgagtgtcaa agattgtgca aacatcataa aagggtcctg catgccgctt acacgtccca 1475401 tcagttttgg atgaacaatt tttggcatcc accctccgat tgcaatgttg atcggtccga 1475461 tacacattcc cagtgcaaaa gctgccgcgt aatacaccca taaaatattg gtgtagccga 1475521 ggacgaagat cagcaaacct gcaatgaaaa tcggtatcga cattaaaaag tgcggcttca 1475581 cttttttaga gatgagcgtg ccgattacgc ttcctgccag aagcccaaac ccgagtgcga 1475641 tcgtaaatac agacgtatgc cactcataac ggtcaggcgc caatccatat ttcattgtaa 1475701 acatcggcaa tacggcgaat cctccattga caaatccaaa aatgaagaag ccaaaaataa 1475761 gagatgccag caatttgttt tttaaaatat agaggatgcc ttctctaaag tcatttattg 1475821 aatccttaac agaagtcttt ctccagctga atgcaccgtt tggctgtcgg gcttcttttg 1475881 gaatccggca gctgcggatc agcagcccgg aaatgataaa gctgacaaaa tcaagaataa 1475941 tggcgccttc aataccgatt gtgttgtaca taaacgcgcc tatgccgact ccaaacacca 1476001 taaaaatgct aaaaagcatc tgattaagcc ctgccgcttt cgcataatgc tccttcggca 1476061 gaatggcttg taccaaactg ttttctgccg gaaagaaaaa ctttgttaca gcgcttctga 1476121 taaataagat acaaaaaaca agaggaatat tgccggtaaa taaagtgaaa aaaagcacga 1476181 cagtcaggcc tgctctgatc caatcacaat tttctgccac cttttttcta tcaaaccggt 1476241 ccgcgacgac tcccacgatc agaaatacaa atatggtcgg aagagaatac atcagctccg 1476301 ccaaggtcgt atatgaaggc tggctgctga atcggtccag caaaaaaaaa gcaaaggcca 1476361 tgttgcctac tgtcgtgccc atttgagaag cgagtgctgc gaaaaataga cgaacaaaat 1476421 tacgattttt aaatatatcc ataaaaacgc tccttaccct aaaggtccca ctttatcata 1476481 ttataaaccg cctgtttttg aaacaaataa gaaaacatta ccggttaatc gtgactctcg 1476541 ttccgtttgg cacaattgaa gcaagttcga tcacgtcttt gttatgcatg cgaatgcagc 1476601 ctttagaaac agccttacca atcgaagcgg gattattcgt cccatgtatt ccgtagtgct 1476661 gctttgaaag gctcagccaa taagcgccaa atgggccgcc gggattgcgc tggcggttaa 1476721 taatgtaaaa ctcgccagta ggcgtttgcg ttagtatttt accaacggcg atgggatagg 1476781 ttttcattac ccgattattt agggacagcg taagggtctt cgctccgatt gagactgcga 1476841 tatgatacgg aattgtataa gggtccggca gtccggggat gactatggac tgtcccgcgg 1476901 tgagccctgc ctgcagtgac ggattagcct ggagtaatgc agccgtgctg attctgaaat 1476961 cagccgcgat gctgttcagt gtatcacctt gcttcacctg gtacgtaagc agtttcctca 1477021 tcctcctttt ttacttataa gtattgatga ggagcccatc ctgctacatt aatttgtgct 1477081 ttttaaggtg aagacagtga tttcaggctt ggcaagaaac cgcaaaggca gcctggtcat 1477141 cccgaggcct cggtttacgt aaatatgagt gctgcccgtt tgatacattc cctctgtgta 1477201 gacttttcca tatggaggcg taataatcgg tccgtaaaaa ggcagctgaa tctggccgcc 1477261 gtgtgtatgg ccggaaagct gaaggttcac gggataatct gttgttttca aggctgcatc 1477321 aggttcatgg acgagaagaa tggaaaaaag tctgtcgctc agccttgaaa gggtgccttc 1477381 ataatctggg tttcccagca ttaagtcatc aagcgaagca atctcgattt tgctgccatc 1477441 tgcgagtgac aatgtttgat agccattgcg atataccgtg aaacctccgg ccgtcatcag 1477501 gcttttgtaa acggcagttc catagcctcc gtgatcatga ttgccgtaaa tacaaagctt 1477561 gccgaaggga gcattaagct ttctcaataa tggaatgact gcctggtggt gctggtacgt 1477621 atcaggatta tcaataatat cacctgtaaa aacaatgaga tcaggtttag attcattaat 1477681 tgtaagaatg acagttttta aatcttcgag agtaaagtaa tcactcaagt gtgcatcgct 1477741 gaactgcacg attttaaaac cgtcaaatcc gtgcgggatg agagagcttt ttattgtgtg 1477801 ttcggttgtc tcgatcatat gcggctcgag atacctggca tagccatatc ccccgccggc 1477861 cgttaaagcc ccggcagcaa gagcgccgaa cattcctttt agaaattgtc ttctggacat 1477921 ctttttcatt tcaaaccaac ctttaataga gtttttctat tatatcatct gtatctgata 1477981 aaaatctcat atgagcatgt gctgacagag gcagggatat aatgatagaa tattattgaa 1478041 tgaataatca ttcacaattg gagggataaa catggaaaaa aaggcggtaa ttattaccgg 1478101 cgggtcaagc ggcatgggaa aagcgatggc aaaaaaacag gctgaattag ggtggcacgt 1478161 tatggtgaca gggaggaacc atgaggcact tgaggaaaca aaaaaagaaa ttcagacctt 1478221 tgagggacag gtcgcttgtt ttcaaatgga tgtccgttcc gattccgccg cttcagacat 1478281 gattaaagaa gcggtaaaag cctttggccg gcttgacgcg ctgattaaca acgcggccgg 1478341 aaactttatt tgtccggcag aaaagctgac gcccaatgga tggaaagccg ttattgagat 1478401 tgttttaaac ggcacatttt tttgcagcca agcagcggca aggcattgga ttgaccagaa 1478461 gcagcagggt gtcattttaa atatggcagc cacgtacgct tggggagcgg gagcgggggt 1478521 cgttcattcc gctgcagcca aagcgggggt attgtcattg acaagaacgc tggccgttga 1478581 atgggggagc aaatacggca ttcgtacaaa cgcgatagcc cccggaccga ttgaacgaac 1478641 aggcggtgcg gagaagctat ttgaatcgga aaaagcgatg gcccgcacga tgaacagtgt 1478701 gccgctcggc cgattgggca caccggagga aatcgccgct ttggcagcgt ttttgctttc 1478761 tgatgaagca tcctatataa acggggattg tatcacaatg gacggggggc aatggctgaa 1478821 tccttatccg ttttaatctg aatatttata agtgaatatt taagttatta agaactttta 1478881 tgttcgaatg taatacctcc acaattaacc ttcttcctat ccaatttgat aacacataga 1478941 gctttatttg tttatgaggt gttgtgtcat acgtaagcca cctaatatat gaaaggtata 1479001 ttttaaaagg ggagacgaaa tatgaagaac ttagatttca aataaaacat tcatataatt 1479061 acttcgttaa ctaaaaagag aaattataag aatgaaaggt ttcaaggtta catcagattg 1479121 ggaggaaggt aatataatgg acgagatggt attattaact caggaatggc tcaatgaaac 1479181 gtacaaagga aaaagtggct acaattccat tgaggaaaat gggaaaactg gctggaaaac 1479241 aatgtatgca ttaactagag cattacaact agaattggga attacacaga cttccgacag 1479301 ttttggtcct acaactttaa gaaagcttaa agaattaggc ccgatttcta cgtcaactaa 1479361 ttcaaaaaaa aatattgtga aaattattca aggtgctctt tattgtaaag gttatggtcc 1479421 aggtggatta acgggtacat ttggtcaggg aacgaaagag gcgatagcag aaatgcaatt 1479481 gcatatgggg ctttctaaaa cagacggtgt agtaacgcct aaggtgttta aagctttatt 1479541 aaacatggac tcttatatcc ttttaaatgg ggcgtcagag aaagttcgtt caatacagca 1479601 atggctaaat aataaatatt acaatagaga gaatttctac tttatgccct gtgatggcct 1479661 gtattcaagg gatactcaaa agtctcttgt ttatgcaata cagtacgagg aagggttaag 1479721 tgatagtata gctaatggga attttggacc aactactcaa agattgattc ctgtattaag 1479781 aattggagaa acagatgaaa aaaacagttt tattcattta tttcaagctg ctctaatctt 1479841 taatggctac aatgttcctt ttgatggagt atactctgaa tctgtaagat caaaagtaaa 1479901 ggcttttcag tcttttgcaa aattacaaca gagtggtact gccgactttc aaacatgggc 1479961 ttcacttcta gtaagtactg gagaccccaa tcgaaaagga gttgcttgtg actcaattac 1480021 tcaaattaca tcggacaggg cggagtccct taagagggca ggttataaga ttgtagggcg 1480081 gtatctaaca aatgcgccgg ggagtacact aaataaaaaa atacaaccag gtgaattaga 1480141 aactatctta aaatcaggtt taaatgtttt tccgatttat caaacctatg ggggagcaac 1480201 aaattatttt aataaagaac aaggaaagaa agatgcgttt gctgcttata aagcagcaaa 1480261 agaatacggg tttaaaaata acactgtaat atactttgca gtagattatg atgcatatgg 1480321 taacgattta aacaacaata ttattccaca cttcgaaggt ataaatgaaa taatgaacgg 1480381 ttttttaggt tcaacttaca aaattggtat ttatgcccct aggaatgtat gtactatagt 1480441 ttctaaaaaa ggtttagcat ttgcaagttt tgtaagtggt atgtctactg gctttagcgg 1480501 aaacttagga tatcctttgc cttacaattg ggcgtttgac caaatttcaa caattactgt 1480561 tggaaatggt tctggaatga ttgaaattga taatgatatt tgttcaggtt tggataatgg 1480621 agttaatacc ataaatatag tgccttcaga gaataagaag ttttttgatc aaattgatgt 1480681 tttatatgaa actgctgaaa aatatgctca aatgcaaagc gacttaaata atggggtaaa 1480741 aaaaacacaa ttagctaatg agttggttgc ccagtattta agaaaggatg actacaaagg 1480801 gtggaagtgg gtccctaccg caggccagat tgatcctatt tatcgtgaat gggcagtaaa 1480861 gcgctagggg aagacctagt aaatggaatt gttgatccta tatcaaaaac tgtcatagga 1480921 acgcagcatc ttatggcaac ttataatgcc attatttata gtggtggtta ctctcaaaca 1480981 ctacgagatt ttgctggttg gactggagat ctattaacaa caatacagga catgaaatta 1481041 cacgctcaag aatttaattc gccttatgat gcggctatga aaataatagg taatatgtat 1481101 caatttagcc tagatgattt atttagtgat gtagatgcaa ttaatctagc gaataaaaca 1481161 tcagttggtg ctaatgcaca acctctaaat atcgcaatta gagattatta tagtaataat 1481221 gactgtatga ataggttcac tcaatttgta aataatagat ttgatggttc gttagacaaa 1481281 attttctctg aagcagagta ttatttaaat acaaaccttg acccagttgt tgttccaatt 1481341 aggttagcct ttaaacgtgc ttttgatgtt gaggattata gtgaagagat tggaaaaata 1481401 acagcacaag catttagaga tgttatcgag aaaaaaatga tatctgaata aactgcaaaa 1481461 caagcgaacg ttaaaactgg tcgttcgctt gttttatttt ctatttaaat ttatgatata 1481521 atttttaaag attaaggagt gattcattga agaaattgtt aaaaaagtta gttgtattat 1481581 ttttaagcag tttagttatc atctttaatg tttggtactt tattatttgt gctttttccc 1481641 cagagtatta tcaaaataca aatcttactt ctaatgaaat aataagattt gaaaaactat 1481701 accacataga ttttcctgat gaaacaaaat ttattaaagc tagagagtat ttggctgggc 1481761 ccggaggaga tacgtcagct gtattatatg tgtctctgcc aaccaagcgg gtagaaaaag 1481821 ttttatctga ttacacgtat atgaaaataa actatactga caatgtcggt tcaatgtatg 1481881 gagttgacgt ttcaaagagt gtcgccggtt taacaactct tacatttggc acttacgata 1481941 aaaaaggaac tttctataat atgaaacatg atgatgattg gatgtataaa ggcactgact 1482001 ggaatcttta cttttggaca gctgctagtt ataatgctgt tatttttgta tttgttttgg 1482061 ttattgtgaa acaaatgaat aaaattctta attaaccagt atgtagattg ataatctcaa 1482121 aaaaattttc ctcttctttt aacatactcc atacgaccta cttttccata ctatgatttt 1482181 tttgaaattt gtggtgtagt tataattgtg cgtataatca gacaaagata gagaagcagg 1482241 tgataacatg ttggatccac ttgatatttt aacgaacatt gatgatgtcc ttccatatta 1482301 ccaggcgatt tttagtgccg aggagcagaa ggttgtcgga tatgaggtgc ttggacgaat 1482361 tttggcagat tcagaaatcc aaagtctcgg gcccttcttt ttagatgcgg ggatacccga 1482421 agaatataaa ttagaggttg ataacagaat tatccgccag gctcttgacc gctttttaga 1482481 ggcggattct gatctgctga tttttatgaa tcaggatgcc aatctgctga tgctggatca 1482541 tggtgaaagc tttctggagc ttctgaaaga atatgaagcg aagggaatcg aactccaccg 1482601 ttttgtgctt gaaattacag agcacaattt tgaaggggat attgagcagc tctaccatat 1482661 gcttgcatac tatcgtacat acggaattaa aatcgcagtt gacaacatcg gaaaagaaag 1482721 cagcaacttg gacagaatcg cgctgctctc accagatctg ttaaaaatcg atttgcaggc 1482781 gctgaaagtg tcacagccgt caccgtcata tgagcatgtg ctgtacagca tatctttatt 1482841 agcaagaaaa atcggtgcgg cgctgctgta tgaagacatt gaggcgaact tccagcttca 1482901 gtacgcctgg agaaacggag gccgctattt tcagggctat tacttagtgt ctccatctga 1482961 aacgtttcta gagagagatg tattgaaaca aagacttaaa actgaatttc accaatttat 1483021 cacacatgag aaaaagaaac tggagaccgt ctatgagcac tctgaacagt tttacaaacg 1483081 agtgcatcag gctgtgacct ctttgagaaa aaacaatctg tcttctgatg atgactttat 1483141 taaaaagctg gcggaagagc tgacagattg cagcttcagg atttacatgt gtgatgaaga 1483201 aggcgatcag ctgacgggaa atgtgtttaa gcaagatgga gaatggattt atcagccgga 1483261 atatgcggaa aagaactgga gctggcgccc ttattttctg gagaacatta tgagaatgag 1483321 aaatctcaga aaaggttttt tcagtgatct gtacagtgat ttggaaacag gtgaaatgat 1483381 cagaacgttt tcatatccga tggatgatca gatgtattta tttatagact tgccttattc 1483441 ttatttatat gagcaggacg gactgattta acggctgaaa ggccgttttt tttatgaaat 1483501 gaaaaaaata tcaaaaaacg attgacattg atactgagaa tcattatcat ttaattatag 1483561 agagaagcta ctctctgttc cccaacccct ctatcagatc aagatccgaa aaaacttggc 1483621 gctacccccg ccaagttttt tatttgtcaa agcataggac aatccaatga aacaataaac 1483681 ctaactagtg gtaaacgttt aacacgggga gaaacattga gtgccgaaca cccctgacac 1483741 tgctgcacgg gtgaggagga aaattcgttc tgaaatgatt atttcagttc cgttgtttac 1483801 ctctatccag catgactccc attgattatg gccacgcggg acttcaccat aaaattcaaa 1483861 agaaggtttt gacaaagttg caaaaaggca ttcttaatgc tgccaaagat tcgaaaaaaa 1483921 ttataattat gtgcatgaca ttcaaaaaaa gcctcaaact aaagaaaaat agtttttttc 1483981 actttttttc tttgcttaaa ttcagcagtg aaaatgccat cctgtccgac tttatggtat 1484041 gatgctcaat agaacttgta ttataataaa tacttgttga tttgaagttg ctttttgaaa 1484101 ggagtctttt tttagaatgt cacaattaat gggtatcatc acacggctgc aaagtctgca 1484161 agaaacagcg gaagcggcta acgagccaat gcagcgttat ttcgaagtga atggtgagaa 1484221 aatatgcagt gttaaatatt tcgaaaaaaa tcaaacgttt gaactgacgg ttttccaaaa 1484281 gggtgaaaaa cctaacacat atccgtttga taatatcgac atggtttcca tcgaaatctt 1484341 tgaacttctt cagtaagatt cctgaaatag ggggaacaag cttccgcctt tgcaaaagta 1484401 atcgaaataa acggtaagga acatacttgt ttcatggttg taaatccttg aaaaggagtg 1484461 tcgtgatggc tgattctttt ctgttttata atctttcaga agcacagatg acctttcaag 1484521 atgtgatgga acggcttaaa gcctttgttc aaaaggaccc ccgttcttct tatgtgttat 1484581 cgatcggaac cgattcacag gtttaccgcg attacacaaa gtttattacc gcattgcatt 1484641 tgcatcgtac aggcaaggga gcttggggct gcttgaaaaa tcatacagtc gacagaccca 1484701 tacatagcct tcgggagaag atttcgttag aaacggcgta cagccaagaa acggccgctc 1484761 atattcttga tggacactta atggatatta ccgatctgct cctgcccttt accggtgagg 1484821 gggcggatct tacctttgaa gttcacttgg atattgggaa aaaagggctt acaaaagatc 1484881 tgatccaaga aatgactgga cgtattacct ccatggggat tgaggccaaa ataaagccgg 1484941 attcatacac tgccttcagc tatgcaaatc gtttcacaaa ataatttggc tgaaaaagcc 1485001 aaggtaaatg tcgaattatg cggttgacgt ttgttatctg attacttatt ctagcggtag 1485061 agctgaaagt aagttgtctt gctttcagag gtattcagta taaaacaggg ggcctgattg 1485121 cgaatgagtc ttatcggtga acgatttaca gaagaagaac aaaaacttct gctgaatatc 1485181 ctgatcaacc atgagtatgc catcgagcta ttaagcagtg agatcaacga tatagagaca 1485241 gggaccaaaa acgttgacgg aaccacctac aaaaaacttg taacgctata cgaccgattt 1485301 cgatttgaaa attaatggga caccctataa ttgatactcc acaaagagta tcttttttat 1485361 tgaaaggaaa cttttcgaca aatactgata aagtttatat tattgcaata tagggaatgt 1485421 attgatgatg aaaatgaaaa ggggtcgaaa acatgataag cttacaatca gatcaacttc 1485481 ttgaggcaac agtcggacaa tttatgattg aggcggacaa agtagcgcac gtgcaagtcg 1485541 gaaataacct tgagcatgca ttattagtat tgacaaaaac cggatacaca gccatcccgg 1485601 ttctggatcc ttcctaccgt ttacatggct taatcgggac aaatatgatc atgaacagta 1485661 tttttggact tgagcgaatt gagtttgaaa agcttgacca aatcactgtt gaggaagtca 1485721 tgctgaccga cattccgcgc cttcatatca atgatccgat tatgaaggga ttcggcatgg 1485781 tcattaataa cggatttgtc tgtgttgaaa atgacgagca ggtatttgaa gggattttta 1485841 cgagaagagt cgttttaaag gaattgaata agcatatacg ctcattgaat aagtaggctg 1485901 tacggtccta tttttattat ataggcagag tgaaaaaaga aagcgcatac ataatttaaa 1485961 cgagaatagg gcttgaataa gaaactaaga ttttattaga atgggagata agaaaaactt 1486021 attgataaca aaaaggagga cgacatgcag cttcaagagc ttcatatgct cgtagtttta 1486081 gctgaggaat taaatatgag aaaggcggca gaacggcttt ttgtatctca gccggcttta 1486141 tctcagcgct tacaaaccat tgaaaaggcg tggggaacaa aaatcttttt aagatctcaa 1486201 aaaggattaa cggtaacgcc cgccggtgag aaaatcattc agtttgcgaa tgatgtgaca 1486261 ttagagcagg aaagaataag agaaaatatt gacgagcttg aaggtgaaat tcacggcaca 1486321 ttgaagcttg ccgtcgcctc cataatcggt cagcattggc tccctaaagt cctgaagacg 1486381 tatgtggaaa agtatccgaa tgcaaagatc tcgctcataa ccgggtggag cagcgaaatg 1486441 ctgaaaagct tgtatgagga tcaggttcat atcggcatta taagaggcaa ccctgagtgg 1486501 aaggggcgca aagattactt aatgacagat catctgtatt tagtggatac tgaaatttcc 1486561 tgcatcgaag atattgccca tacagaacgt ccgtttatcc agtttaaaag tgacagcact 1486621 tattttcagg aaattcagca ctggtggcat caaaaattta aaacgtcgcc gaaacagacg 1486681 atattggttg atcagattga aacgtgcaaa cagatggcgc tgcacggaat cggttatgcc 1486741 attttgccgt ctgttaccct tcaaaatgaa gataaagtga ataaaatgcc tcttttagac 1486801 atgaaagggc atccgatcgg tcgggataca tggttattag gttatgagcc tgcctttgaa 1486861 ctgaaacaag ttcaagcttt tgtacaagtg ataaaggata tgctggatca ggaaaatcca 1486921 ttttaaagac agcgaggtgc tgtctttttt ttatttatct gttgacaatg aaaatcatta 1486981 tcatttaaag tgatacatat gatattgaaa atcattatca actaatgggg tgataacatg 1487041 gctaaagcct tgattacata tgccagcatg tcaggaaata cagaagacat tgccttcata 1487101 ataaaagata cgcttcagga atatgagttg gatatcgatt gtgtcgagat aaatgatatg 1487161 gatgcgtctt gtttaacctc ctatgattat gtactgattg gcacctatac atggggggac 1487221 ggcgatttgc cctacgaagc ggaggatttt ttcgaagagg tcaaacagat tcagcttaat 1487281 ggtttaaaaa cagcctgctt cgggtctggc gattattctt atccaaagtt ttgcgaagcg 1487341 gtgaatttgt tcaatgtcat gctgcaagag gcgggagctg ctgtttacca ggaaacacta 1487401 aaaattgaat tagcgcctga aacagatgaa gatgtggaaa gctgccgagc gtttgcgaga 1487461 ggttttcttg catgggcaga ttatatgaac aaggaaaaaa tccatgtttc ataaaggggc 1487521 aaccgctgtt acggcatcgg cgttttctgg atattttgtg gcggtacaaa gagaaggcat 1487581 ttttcattac tctttggagc agggctggag aaagcttttt cgtttgaaaa gtaagataca 1487641 ctgtatcagc tacatagggc cttacttatt tggcgttggt gaaaagggaa cagtcattcg 1487701 ttcggctgat gaagggaaaa cctggacgat gtcgagcttt ccgacaaatg caacagtgtg 1487761 ggcgattacc ggcagaaaca acgggtttgt ctgcgcccac ggtaagcatt gtatttatgt 1487821 atcggatgat tttggtgtct catggcgcgt agccaaacct tttgccgaat ttcataatcc 1487881 ccctgttatc cggtcgttat gccttcacgg gggcaatctc tttatcggca cgcaaataca 1487941 cgaatatttt ggcggcattt gggcttacga cattaagcgt gacactgtcc aagttgtcaa 1488001 aaaagaaaaa aaccggatga cggcatccat gctcgtgttc aatgaaaatt ggctggtggc 1488061 ggcgatgggt tctgtgaaag gaaagcacgg tgctgtcact gtaaggaatc ttttgaatgg 1488121 tgaagaattc accatacaat ccagtatgat cagaaatgaa gaatcatttc ttgatctttc 1488181 agaggatgat ggcattatat atgtcactac aacacaagat gaaaatggtt tttcgagaat 1488241 ttaccaggtt gatctcgaag cccggtcgtt aaaatggttc gataccatta agggacatgg 1488301 atggagagtg gccaatcaga aagagaattt cttttgcgca ggcttgtatg aatgtaaatt 1488361 tgtccagccg tacgaagttt cagcaatgat tcattagagg aggaacaagg aattggcgaa 1488421 gattttgctc gtttatgcaa caatgtcagg caacactgaa gctatggcag atttgattga 1488481 aaaggggctt caggaggcgt tagcagaagt agaccgtttc gaagcaatgg atattgatga 1488541 tgcccagctg tttaccgatt atgaccatgt cataatggga acctacacgt ggggagacgg 1488601 agatctgcct gatgaatttt tagatcttgt tgaagacatg gaggagattg atttttccgg 1488661 caaaacatgc gctgtattcg gttccggtga tacagcatat gaatttttct gcggagcggt 1488721 tgatacgcta gaggcaaaaa taaaagaacg cggtggagac attgtgctgc cttcggtaaa 1488781 aatcgaaaat aatccagaag gtgaagaaga ggaagaatta ataaacttcg ggagacaatt 1488841 cgcaaagaaa agcgggtgcg ctgtctgatc actcactggg aactgctaaa acggctgttc 1488901 ctttttttct tgtctttgta tctttccttt gatacagtaa tgaggtagaa aatcaggagg 1488961 aggactatac atatgaaaat gatggacgca aatgaaatta tttcatttat tcaaaatagt 1489021 acaaaatcta cacctgtaaa ggtttacgtg aaaggtgagc tggaaggaat caatttcggt 1489081 gaatctgcga aagcttttat caatggaaac actggtgtcg ttttcggtga atggagcgaa 1489141 atccaaacag caatcgaaga aaaccaaagc aaaatcgaag actatgtggt tgaaaatgac 1489201 cgccgcaatt ctgcgatccc aatgcttgat cttaaaaaca tcaaagcgcg tatcgagccg 1489261 ggtgcgatca tccgcgacca agttgaaatc ggtgataacg cagtcatcat gatgggtgct 1489321 tctattaata tcggttcagt catcggcgaa ggcacaatga ttgatatgaa cgttgtgctt 1489381 ggcggacgag ctactgttgg aaaaaactgc catatcggcg cgggttctgt acttgcgggc 1489441 gttattgagc cgccatccgc taaaccggtt gtgattgaag acgacgtcgt aatcggcgca 1489501 aatgctgttg tgcttgaagg tgtaacagta ggtaaaggag ctgttgttgc tgcgggagcg 1489561 atcgtggtaa acgacgttga gccatacact gtcgttgcag gcacaccagc taaaaaaatc 1489621 aaagacattg atgaaaaaac aaaaggcaaa actgaaatca agcaggaatt acgccagctg 1489681 taaggaaaag tttgataaaa aaggcgtgga taatatatcc acgccttatt cgtataggca 1489741 ggaggaatag aaatgaagat agaggagctc atcgcaattc gcagagatct gcatcgtata 1489801 ccggagcttg gatttcagga gttcaaaacc cagcagtatt tattaaatgt cttggaacaa 1489861 tatccgcaag acagaattga aattgagaaa tggcgaacag ggctttttgt aaaagtgaac 1489921 gggacggcgc cggaaaaaat gctggcatac agagcggata tcgatgcgct ttctatagaa 1489981 gagcaaactg gtcttccatt cgcatcagag catcacggca acatgcacgc ctgcggtcac 1490041 gatttgcata tgacaattgc actcggcatt attgatcatt ttgttcacca cccagtcaaa 1490101 catgatttgc tttttctgtt tcagccggca gaggaagggc ctggcggtgc ggaaccaatg 1490161 cttgagagcg atgtattaaa aaaatggcag cctgatttca tcactgccct tcatattgct 1490221 ccagagcttc cggtaggcac cattgcgaca aaaagcggcc ttctatttgc gaatacatca 1490281 gagctagtca tcgatctgga aggcaaaggg ggacatgcgg catatccgca tttggctgag 1490341 gatatggttg tagcagcaag tacacttgtc acccagctgc aaacgattat ctctagaaac 1490401 acagatccgc tagacagtgc tgttattaca gttggtacca ttaccggagg ctcggcacaa 1490461 aatatcattg cagaaacggc ccacctggaa ggcacgatcc gcacgctttc tgaagaatcg 1490521 atgaaacaag taaaggaacg gattgaagat gtagtgaaag gaatcgaaat cggattccgc 1490581 tgcaaaggaa aagtgacata tccgtctgta tatcaccaag tttacaatac gagcggatta 1490641 acagaagaat ttatgtcttt tgttgctgaa catcaactgg cgacagtaat tgaagcaaaa 1490701 gaagcaatga ctggagagga ttttggctat atgctgaaaa aatatcccgg attcatgttc 1490761 tggctcggcg ctgattctga acatgggctt catcatgcta agctgaatcc cgatgaaaat 1490821 gcgatagaaa cagcggttca tgtcatgaca ggttattttt ctgtttatgc caattaagta 1490881 caaatgaaag aataaaattc cataaaatga gcactctagt aaacggaggt gttcaaaaat 1490941 ggctaaaaaa attggaattg aacaatcgtt atcagatgta gaagctgctt taaaagaaaa 1491001 aggatatgac gttgtaatga tgaaaagccc tgctgatgct caaggctgtg actgctgtgt 1491061 cgtaacaggt cttgataata atgtgcaagg gatagccgat acggtaacac aagcacctgt 1491121 cattacagct tccgggatga cggctgaaga aatttgtagc gaagttgaga gcagaattca 1491181 gtaataaaaa aaccgaagca aaaagcttcg gttcttttat ttattctgtt tctttaggga 1491241 aagcgcggtc gaacgcgttc tttatttctt ttctcaacac tcgttcgact cgccactgtt 1491301 ccatattttc tgttttggca atgaccctga ttacaatttc agaagtcccc agttcttgaa 1491361 tcccgatgac atttgggcct tcttttattt gtggaagagc cgctgccgtt tcatcacaaa 1491421 cctgctgtaa aatatgaatc atttcatcaa tatttctttc agccggcact ttaatgtcaa 1491481 caagagcctg catggtacca cgagaatgat tgctcacgtt tgtgatgttt ctgttgggga 1491541 tgtaatgcag tgttccgtca aagctgcgga tttgagttgt ccttaagcca acctgctcga 1491601 caattccgtc aaaggtggaa acggtaatat aatctccgac atccaattgt ttctcaagca 1491661 aaataaaaaa acctgtcacg atatcactga caagcccttg ggcgccaaat ccgacagcca 1491721 ggccgacgat tcctgccccc gctaaaagag cgcttggatc ataatgaaac aaatctagaa 1491781 ccatgacgaa aaatatgaaa atcaatgtat aagcaaatat gttaagagtc aggcttcgga 1491841 gcgtatgtgc acgtccgata gacaagctat tctgctcctc gaattttgca aacagatgtt 1491901 taatgatttt catgcctaat gatcgaacga taaaatagag caatatcata atggcgagtt 1491961 taatgagcag aacaccggca tttgtaatca gtcccgccca atcatattgt ttaataaagt 1492021 ccatgttgag ctccttttct aattgattgc tgcacattga gactagttac cctgtacatg 1492081 accatgttaa acgttttatt caaaaatgtc gaagccaaag acatacatga tttgttaaaa 1492141 attgactcag gaaatctgct tttatataat ggcattgcaa tataactaaa aatggttaat 1492201 caccctttat tttcatgcga ttttgacctt taagccaaac aataaattgg agggatacat 1492261 atggcagaac gtatggtagg taaacaagct cctcgttttg aaatggaagc agtccttgca 1492321 agcaaagaat tcggcaaagt aagtcttgag gaaaacatga aaaacgacaa atggacagtg 1492381 ctgttcttct atccaatgga cttcactttt gtttgtccga cagaaattac agcaatgtct 1492441 gaccgctatg acgagttcga agatcttgat gcagaagtca tcggggtttc aactgatacc 1492501 atccatactc atttagcttg gatcaataca gaccgcaaag aaaacggtct tggccagctg 1492561 aaatacccgc ttgctgctga tacaaaccat gaggtatccc gggaatatgg cgttttaatc 1492621 gaagaagaag gtgtggcttt gcgcggattg tttattatta atcctgaagg ggagcttcaa 1492681 tatcaaactg ttttccataa caacattggg cgtgatgttg atgaaacgct tcgtgttctc 1492741 caggcgctgc aaactggcgg actctgtccg gctaactgga aaccaggcca aaaaacactt 1492801 taattctttc caagaacgaa aagcggtcta gcatattcgt taggcctctc ttttaaaata 1492861 ggagggaaaa agcaatgaaa ttacgtcagc ccatgccgga attgacggga gaaaaagctt 1492921 ggttaaatgg tgaagtgacg agagagcaat tgattgggga aaagccgacg cttattcatt 1492981 tctggtccat cagctgccac ttgtgcaaag aagcgatgcc gcaagtgaat gaatttcgtg 1493041 ataaatatca agatcagctg aatgttgtag ctgtacacat gccccgttcc gaagatgatc 1493101 ttgaccctgg taaaattaaa gaaacagctg ctgaacacga tatcactcag ccgatttttg 1493161 ttgacagtga ccatgcttta accgatgcat ttgaaaatga atatgtacct gcatattatg 1493221 tgtttgataa aacaggacag ctccgtcact tccaagccgg cgggagcggt atgaaaatgc 1493281 ttgaaaaacg tgtgaaccgc gttctggctg aaacggaata ggtatctgac taaatagtat 1493341 ttcctaaaaa cctgacctca tcaggttttt tatttgtgca aaaagcaatg gaagaagagt 1493401 aagaagctta tttttccaaa tttgggtata ggaattgatg atttgtttga ttgatacgct 1493461 aaaaaacaca gctaattttt gatgtttttc ctcaatttta gataaatctc atatctcata 1493521 actcgaaaat tgtagatatt acactaaatt tctttaaaga agtaagtaaa atatatattt 1493581 tcaacattat accaaataaa ctagaaagcc ccttaatccc ttgagaataa aggactcttt 1493641 tgaaaaataa aacattttca gaaaataagg aatttttcat agagtaaata taatagtaaa 1493701 atgctaaaat aatagttgat aaaattactt ttgtaatcta atatcttaat taaagatgtt 1493761 aattttgata gggggtacat tgaggaatgt ttaatgaaag agaagctttg cgcttgcggt 1493821 tagaacaatt aaatgaagct gaagtgaaag tcattcgtga atatcaaatt gaacgtgata 1493881 aaatatacgc aaaattaaga gagctggaca gaaatggaag cccttccgaa atcaaaaagg 1493941 atttccgttc tgaaaaaaaa cctgactctc tgccggttct cgctgagctt gcggctcagg 1494001 aaatcagaag ctatcagccg caatcacagc agcagtctgt tcagcctcag cttcaatcta 1494061 tttcctctct tcctgccggt ataccagacg gaacaacacg aagaagaaga ggaacggcaa 1494121 gaccgggatc aaaagcagct aagctgcgtg aagctgctat taaaacatta aaacgccaca 1494181 acgcggcgat taagagctcg gagcttcaaa aagagattga aaaagaaagc ggtcttgaaa 1494241 tccctaatat gacaacgttt atgcaaagct taattaaaat gtacccggaa gtgaaaaagc 1494301 catatcgcgg gcagtacatt ttagagggtg aaatcgaatc tgcagaatca gcaaacgaat 1494361 aaatataaag aaaaactgct tggcatcgct caagcagttt ttttattgag gttttttctg 1494421 tgaaggtttg ttttcttttt caagattaag cttatacacc cacttttgat aaggcttttc 1494481 ttcagcggct ctgtttttca gctcttcgat tgtatggctc ttggcctggt ctgatgattg 1494541 ggcgtgggca agctgttttt gaagcacatg tatctgtttg gtgacatctt caaggatagt 1494601 ctctacatga tttggctgcg cgtaggccgc tggagcttct tcttccgttt tttctttttg 1494661 tttcgtgccg ccatcaatat cggcaaaatg agaagcaatc caggcatcgc tttcatcaag 1494721 ttgccgttta tacgatataa tagtttcgtg aaataatttt tctttcgttt tttctatgtc 1494781 tagcagtctt tctttcgttt ctatgattcg atctttcata tgatcaactt ctattttaat 1494841 atgttttagc tgatattctt tttctaccat ttgctctttt agacgcccgt tttcggcttt 1494901 tatcaattcg gcttgctgtt ttgcctgaag cagtgcattt tgttcctgct caattgaggc 1494961 ttgaagttcg ctgatccgtt tatgaagatt tttattttct tcttcgattt tgactttcgc 1495021 aatatgaagt ttatgttttt cttcgatttc ggctctgcgt ttataggttt cagcagatag 1495081 aagctcctgc aaaacaacga ttttatcaag cagttcagct cttatttggt gcagggtttg 1495141 gctggtgtgg gaggcatgtt tttcttttgt tgacatatgt gttaattcgg cagacagctg 1495201 ctggagtttt tctttcatat cggtattttc tttgagcagt ttgttatttt tctgatgaaa 1495261 gtagcttgct tcaagttcag aaatcagctt atggcacctt gaaagctcgg attttaaata 1495321 aaggttctcc tgagacacgt cgtggaaaaa aggacctgat cttttcattc gaaccatctc 1495381 cctcatgatg ttaacactac aatatgcaaa tactgaacag ctattcctct ttaataaaca 1495441 gacaagcagt agcgttgagc ctttgctttt gctatgcttt taacgaaact agaggtgaga 1495501 tgatatgaag catgtaaacg tactgctggc agggggagcc tcacgtcgct ttggagaacc 1495561 gaaggcgttt gtcaaatgga agggcaggat gctttacgaa tgcgctaaag aggcacttgg 1495621 agaacaaacg gttatcatca gccgtcccga atttattgat agatttcaag aaaacggtga 1495681 aaatgaagtg tatcaagatg ctgagccatt tcaaggcatg gggccattgg ctggtatata 1495741 taccgctttt aaaaagacag acggtgatct ttatactgtt ctttcctgtg acacaccgct 1495801 gatacaaaga aggacgatgc tggagctcaa acgtctgatg attgccggtg cggacgcggt 1495861 agtcccaatt tcagacggac aagtgcagcc attgattgcg atttaccaca aacgtatcat 1495921 gccagttcta tacgatcagc tttctgagaa gaggttgaga atatcagatt tattaggcag 1495981 aatttcggtt tgttacgtac aggctgaaaa tatcggagca aacccggcag agtttatcaa 1496041 cattaataca cgtgatgatt ttagctgttt ggaagaaaaa tcgaactccc tcaagcggga 1496101 ctgacggggc aataacatga taagatgaca taaaagataa ggagaacagg tttgatggag 1496161 gaacgttatt cacggcaaat cagatttaag caaattgggg aagagggcca gaaaagactg 1496221 gcagacagcc atgtgctgat tgtcggagcg ggagcgctcg gcactgcagg agctgaaggg 1496281 ctttcgagag cgggagtcgg tacgattacc attattgacc gtgactatgt ggagtggagc 1496341 aatcttcaaa ggcagcagct ttatacagaa agcgatgcca aactccgcat gccgaaagcc 1496401 atggctgcca aagagcatct atcagcgatt aacagcgaga tacatattga ggcgtatgtt 1496461 accgaaggaa cagccgaaac gcttgagccg ctgattgaaa aagcagatgt cgtgatcgac 1496521 gcgacagata attttgaaac ccgcatgctg ataaacgatc ttgcccagaa aacaaagaca 1496581 ccttgggtct atggcgcctg tgtaagcagc cagggaatgt tcatgactgt cattcccgga 1496641 gaaacccctt gtctgtcttg tttgtttgag caaattcctg tcggcggggc gacgtgtgat 1496701 actgccggca ttattccgcc tgctgtgcat atcgtttcag catatcagca ggctgaggca 1496761 ttaaagctgt taaccggcca aaaagaagca atacagcggg ggtttgtgac atttgatgtc 1496821 tggaacaatt cgcatatgaa gattaacgtt aatcatgtac gccgtgagga atgcccatct 1496881 tgcggagcta atgcggtata tccttatctt caggattgga acacaccaaa agctgctgta 1496941 ctatgcggcc gtgatacagt gcaggtaagg tcagaatcat taaaaagaat cccgaaacag 1497001 gagctcatta agcggctgaa aacaatcggc aaggtcgagg ctaatgcgtt tttgctgcat 1497061 attttttacg aggatttcag aattgtcatt ttcaatgacg gacgggcact ggtgcatgga 1497121 acaaatgatg tgaaagaagc caactccgtg ttggcaagag tgattggact gtaacaacag 1497181 gaggggtcag aatgctggag aaaagaacac cgataccggt agacgaggca gttcggcgtg 1497241 tctgccattt tcaaaaacaa ggtgaaacag aatgggtggc gcttgaagac agccttcatc 1497301 ggtttttagc cgaagatata actgcggatc accacgtacc tgcgtttgac cgttcgccat 1497361 acgatggttt tgctgtcaga gcgtgcgata cggcagaagc ttcacgtgaa aacccagttc 1497421 ggtttgaagt tattgaccat attggagcgg gagcagtatc tgaaaaagaa cttggcccgt 1497481 ttcaggccgt gcggattatg actggcgcgc aaatccctga aggggcagat gcagtcgtca 1497541 tgattgaact gactcaagcc tttgaggaga atgggaagtc atttatgtct ttaaaacgcc 1497601 gctttcagac gggggataat atttcaaaaa caggtgagga cgctcaaaaa gggagtgttt 1497661 tactgacaaa gggcacccgg gtgacaccag gagtgacggc tcttttggca acattcggat 1497721 acgcatctgt gcctgtcgtg agaaagcctg tagtcgggat tatcgcaacc ggtaccgaat 1497781 tgctgaatgt cagtgatccg ctggaaccgg gaaaaatccg caacagcaat gcgagtatgg 1497841 tatatgcgca agcgatagaa gcaggcgcaa caccgcttta tttagggaaa atctctgatg 1497901 aactggataa aagctttgct gcagttaaag aagcgatgaa aaaggtggac ttcctgatca 1497961 caactggcgg tgtgtcagtc ggtgactttg actttttgcc tgcgatctat gaaaaactcg 1498021 gagcggacgt gctgtttaat aaagttgcca tgcgcccggg cagcgtgaca acggtggcgc 1498081 atgcaaacga tatgctgctg tttggccttt caggtaatcc gtcggcatgc tatgtcggtt 1498141 ttgaactgtt tgtcaaaccg ataatccaga catggctgct caatgaaaca ccgcattcaa 1498201 tttgtgcgga agctgttttg accaaggatt ttccgaagcc gaacccattt acccgatttg 1498261 ttcgtgcgct cgtgcaccat caggaaggga agctgttggc gacacccgtt ggcttagata 1498321 agtcgagctc tgtcacatca cttgcagatg ccaatgcatt tattatcctg ccgggcggta 1498381 cgcgaggcta cgaatctggc agaacggttc aagtgctgct catcagagaa gagaatggaa 1498441 gtgaatggcc ttggtccgtc ctttcccgat cgtccaagtt gtaggatttc aaaacagcgg 1498501 gaaaacaacg tttattgagc gcattcttga aaaagcctct gaacagggag tccatttggg 1498561 ctgcctgaag caccatggtc acggcggtga accgcaaacg ctcacggaag gaaaagacac 1498621 ggaccgttac aaggcggcag gtgctgatgt aacagcggta gaaggtgctg gtgtgttaca 1498681 gctgactgcc cgccgcaatt gggatttggc acggctgatt gagttatacc aatttctcga 1498741 aacagactgt cttctgattg aaggctttaa aaaagcccct tatcctaaag tggttatcct 1498801 aagtgaaaag gaagatctgg aagcgctgca agcagtaaat ataatcgcca tcatctatag 1498861 aaaaaaagag catatgacag agcatcaggg attacccgtt tttcatgcgg atgatccggt 1498921 tgccgtggat tttgtgcttt cacagctgaa gggggaatct gcataatgga acggtttgag 1498981 attacgaaaa cacccattaa tactgaaaac atcatcaaaa aagtggagaa acgggaagcg 1499041 ggagccatta caacatttat tggtacggtt cgggaatgga caaacggaaa aagaacggtt 1499101 cggcttgaat atgaggcata tgaaccgatg gccgtgcaaa tgcttgctca aatcggcgct 1499161 gaaatcgaag aaaaatggga aggtgcctca gctgcgatca cgcaccgtat aggtgtgctc 1499221 gatatcggtg aagcagcggt agtgattgct gtatcttctc cccatcgaaa agccgcatat 1499281 gaagccaatg agtatgcgat tgaacgcatt aaacagattg tgccgatttg gaaaaaagaa 1499341 atttgggaag acggtgagca atggatcggc gaccagctag aaacgacagc ttatccgaac 1499401 ggaaaaccag acctaagcga gggagagcag catgattaaa attcttttat ttgcagggct 1499461 tgctgaacag gccggtacac aagcaataga aatagatatg gaacaagcaa ccacagatga 1499521 aataaaagcg agtctaaaag aacaatacgg tcttgaatct attgatacgg ctatgattgc 1499581 cgttaacgaa agctatgtaa aagaaaatac ctctgtatct tcgggtgaca cggtagccat 1499641 cataccgccg gtcagcgggg gatgaaaacc ggacggcatt tcagccgtcc ggtttttctg 1499701 tatttcattg gcatatcccc aagtatcctc agcatacaat gattttctgt aagcgtttat 1499761 tctacatatg ttactcccta taaagtaaga gactcactcc ataattagac tgaaattttg 1499821 aaaaataata gaaatttatt tcgggtatcg atatagtgaa gatgataaat gttggaaagg 1499881 tgctggatat ggagacattt aaaagattaa aaatgtatta ttggccgtac agaaaagtgt 1499941 ttatgtggtc gcttctagcc atgcttttga tgactgcaat tactgtcgtt tatccgatta 1500001 tcctgcaaat tacgattgat gagatcgtac tgggacggca gtatcagctt gcggcgtggg 1500061 tcagcttagg atttattgcg gtgatggttt tgaaaggaat ggctaccttt tttcatcagt 1500121 atttaggtga tatgttcggg atcaaatccg tttatcggct gagaaatggt ctgtatgaaa 1500181 aactgcagcg gctttctttt tcttactatg ataacgcgaa aacaggagat ttgatgtcca 1500241 ggctgactgc tgatgttgaa gggcttcgtt ttttcttatc atacggtctc gctgagctca 1500301 ttcgcttcgg cctgctggta gccatcagcc tgtcggttat gttttactat tctgttcctc 1500361 tcacgcttgt gacaatagct gttctgccat ttctcgcggt tgcggtatac cggtttgaca 1500421 aaagagtcca tcccgccttc agaggcatcc gcaaatcgtt tgcgaaactc aatacaaaag 1500481 ttcaggaaaa tatcagcggc attaatacgg ttaaatctct ttccagggaa gattttcaga 1500541 tcagcacttt caataaagcc aatgcagaat acagggcgca gtatttacaa acatcatcca 1500601 tttggtctgc gtatttccct ttaatggagt tcattggtaa cacttgtatt gtagctcttc 1500661 tctcatacgg cggttacttg gttatgcaaa atcagctcaa tcccggcgag cttgttgctt 1500721 tcttcagcct tgtcaattat atgatgtggc ccattatgaa cttaggtttt gtcatcaata 1500781 tgttctctca agcaaaagcg tcaggggaac gcctgctcga cattctggaa aaagaagaag 1500841 acattacaga tcatcctcat gctttgcata aacaaaaatt aaccggagat gtccatttca 1500901 aaaatgtttc tcttgcatac ggaaaagaac aaacaaacgc gctgtgcaat gtaagctttg 1500961 aggcaaacag cgggaaggta atcggactgt tgggcccgac aggttcaggc aaaagctcag 1501021 tgacacagct tctcaccaga ttttacagtc ctgttggcgg aatgattacc attgatcaca 1501081 aacccatcac agattattcg ttaaaaaccc ttcgctccaa tatcggggtc gtacttcaag 1501141 aatccttcct gttttcatct acgattagat caaatatttc gtatgggcgg ccggatgcct 1501201 caatggaaga cgtcatcgaa gcggcaaaaa gggcgcaggc tcataacttt attatggagc 1501261 ttcctgatgg gtatgacacc atgctgggag agaggggaat ggggctttcc ggcgggcaga 1501321 aacagcgtat tgccattgcg agagccatct gcttgaaccc gagcatttta atattggatg 1501381 atgccacaag cgcagtagat atgcaaacgg agcacagcat acagcttgcc ttaaaagaag 1501441 tcatgaaaaa ccgcacaacc tttatcgtcg ctcaccgcat ttcttcactg aaacacgctg 1501501 atgaaattct cgtttttaat aaaggacgca ttcgtgaaag gggaacacat catgagcttc 1501561 ttgaaaaagg cggctactat aaaaagattt acgatttgca ataccgtgat gtcaaaatga 1501621 ttaatgagcc gcatgaggtc ggatagggag gggccaaatg aaacaagcga aaaaacaggg 1501681 ggttttagag cgtttctatt actcttcaga tgaaatcatt gaaaagccgt ttaactgggc 1501741 tcaaatgtgg cggctgctga gctatgtcaa accatatcga aaaacaattt tgccgctttc 1501801 ttttctcact gtattgattg gcactgctgt gaagcttgtg atccccattt tgatcggcgt 1501861 ttatgttctt gatcaagcga ttacagggag aaactcggag ctgctgattc agctcatttt 1501921 tattattagc ggtttatatg tcctcaatta cgccgccaat gtgttaagaa tcaggtggat 1501981 gaatcagctt ggccagcatg tcatttacga tttgcgacag catttattta cccatgtgca 1502041 gcgcttatcc catcgatttt ttgatcagcg gtcggcggga tcgatcttag tcaggatcat 1502101 gaatgatatt aactctcttc aggagctctt tacaagcgga gtcatcaatt tgttgaccga 1502161 cttgctgctt ctggccggcg tgattattat tttgtttacg ctgagccctg agctgactat 1502221 agccatcatg gtgacattgc cgattatgtt ttttatttca acaagtctca gaaaaaaaat 1502281 acgccgatcc tggcaaacgg tacggctgaa gcaatcgaag ctcaactctc atctaaacga 1502341 aagcattcag ggcatccggg tcacgcaggc atttacgcag gaagaagaaa acatggcgta 1502401 ttttgacggt gtcaatcagg agaactacga atcatggcgg gaagcaacta gaaaaaatgc 1502461 catgttccgt ccgcttgtag aaatgacgaa tgcgattggg acggctgtct tgatttggta 1502521 tggagccaca ctcatcatga atgaaaccat tacgattggc gtcttcgttt cttttgcttt 1502581 ctatctggga atgttttggg aacctatttc gagactgggt caggtctata atcagctgtt 1502641 aatggggatg gcatcatcag aacggatttt tgagtttctg gacgaacagc caaatgtcaa 1502701 ggagaagccg aatgccattc ataatgaaaa gataaatggg gagatcagtt ttgaagaggt 1502761 tgaattttcg tatgatgaaa aacgaaaagc ccttcacgcc gtttctttct ctattcctgc 1502821 gggatcgacg cttgcgcttg tcgggcatac agggagcggg aagacgacga ttgccaattt 1502881 aatcagccgt ttttatgatg cggccggagg caccattaaa atagacggta taccgattaa 1502941 ggatctttcc cttgccagtc tgcgctctca aatcagcatt gtcctgcaag atacatttat 1503001 tttctccggg accatcatgg aaaatattcg ttttggaagg ccaaatgctt cggatgaaga 1503061 ggtgatgaaa gcgtcccaag cggtcggagc ggatgagttt atttccgatt tagcggaagg 1503121 atacgcaaca gaggtagagg aaaggggcag cgtactgtct gccggtcagc gccagctcat 1503181 ttcatttgca agagcattgc tcgccgatcc ggctattatc atccttgacg aagcaacggc 1503241 aagcattgat acagagacag aagtaaaaat tcagcaagcg ttaaaaacgc ttctgaaagg 1503301 gcgtacagca gtgatgatcg ctcacagatt gtctacgatc cgcgacgccg accgcatcat 1503361 tgttcttgat cacggcagga aaatagaaga agggaaccat gatcagctgc tcgctaaagg 1503421 aggcatttat gccgggcttg tgaaagcgca atacagcaca gcgatagaat aatatgaaaa 1503481 gccttcaata ttgaaggttt ttggaaattt attagaaaaa catgaaactt tttgatatcc 1503541 ttcccgtact atttgttaga tattctcaag gaggttttga aatggaaacg aatgtagaaa 1503601 aaaacagcgg aacggcgact gaaaagcctt cacttttcgg agtaatcaca agtccgtccg 1503661 ttcaatttga aagaataaga gaaaggccgg ctgtatgggg accgcttttg attgttgcag 1503721 caattatcat cgtcggtgcc gtgctgcaat cactcggtac ggattatagt gagcttttga 1503781 aaagccagga tacgcaaggg ctatctgctg aacaaatgga aactgtcgca acaataacca 1503841 aatttggcgg aatggcaggc gctattatcg gcggtatcgc agcattattt attgcccctc 1503901 ttatttattg gctctgtgta aaagtatcag gcggtgttac gacatataaa aaaatgcttt 1503961 ctctcagtct gtttgtctct ttgattagca gtctcggatt attggttaat ggaatcgttg 1504021 cttttacgac tgacgtgaat cctctttaca gcacgacgtc actcgcaggg attatcccat 1504081 ctgacggggc tctcgccagt gtgttaaata cctttgaaat tttcagcatc tggagctttg 1504141 tattattagc aatcggactt cacaaaacgg gaggcatctc aaaaaaagcc gggtggattt 1504201 cagcaatcat tctattcgga attttagttg tattttcgct tttttcaggt ttaatcaatt 1504261 ctgtggcggg tgcataagct catgaaaaaa gtctggatcg gaattggaat cgcagttata 1504321 gtcgctcttt ttgttggaat caatatatac cggtctgccg ctccgacaag cggcagcgcc 1504381 ggcaaggagg tacagacggg gagcgttgaa gaaaatgaaa tctcatcaac ggttatggtt 1504441 cctggcacgc taaaattttc aaatgaacag tatgtctttt atgaagcgga taaagggaca 1504501 ttagaagaca ttaaagtaaa ggaaggcgat aaagttaaaa agggcacggc tttagtcacc 1504561 tatacaaatg agcagctgag cctggaaaaa gaacagaacc agttaacgtc tgaatccaac 1504621 cggcttcaaa ttgaccaaat tcaagaaaag ttaaaagcct tggacagcaa agaaagagaa 1504681 ctggaaaaac aggtaggaaa gaaagaagca gaaaaacaaa tcgaatctga acggacagag 1504741 cttcaaatgc agaaaaaaac agcggagatc gaattaaaac aaaccgagct tcagcggcag 1504801 tcacttgcca accgggtgtc agatttagaa gtgaaaagcg aaattgaagg caccgttatt 1504861 tctgtcaacc aagaagcggc atccaaaaag tcagatattc aagagcctgt catacatatc 1504921 ggcaacccaa aagaccttgt cgtctcaggg aaattgtctg aatacgatac attgaaagtc 1504981 aaaaaaggcc agaaggtcac actcacttca gatgtaatac agggtaaaac atggaaaggc 1505041 acggtttccg cagtcgggct tgttccggat cagcaggaga gcgctgcggc acaaggaaca 1505101 gaacaggcgg tccaataccc gcttcaagtg aaaataaaag gaaatcttcc agaaggaaag 1505161 ccaggcttta aatttatcat gaatattgaa acagataaac ggaaagcaaa tacgcttcct 1505221 tcaaaggcag tcaaaaaaga agatgaccaa tattatgtgt atacagtaaa agacggaaaa 1505281 gcaaagcgag ttgatgtcaa aatcggcgaa gtgacagatg acctgacaga aattaaagag 1505341 gggcttaccc aagatgatca agtcattttg aatccatctg atcaggtgac tgacggaatg 1505401 gaagtgaaat cctaaatgat tcagctttct aatgtgcgaa aaagctacca gatcggaaag 1505461 gaaacgtttg atgttctcca ttctattgat ttggacattc atcaaggtga atatgtctcg 1505521 attatggggc cgtcaggatc aggaaaatcg acgatcatga atattatcgg ctgtcttgat 1505581 cggccgactt ccggtacata tcaattggac ggcgaagaca tttcttcata taaagataaa 1505641 gaactggcgg cagtccgtaa ccggtccatc ggttttgtat ttcagcaatt tcagcttctt 1505701 ccgcggctga acgcaaaaaa aaatgtcgag ctgccgatga tttattccgg gataggcaaa 1505761 aaggaacgtc aagagcgggc tgagagagca ttggaaaagg tcgggttagc cgatcgaatg 1505821 ctccacatgc ccaacgagct gtcgggcggg cagaagcagc gggtggcgat tgcgagggcg 1505881 atcgtgaatg agccgaaatt gattttagct gatgaaccga ccggcgcgct ggatacgaaa 1505941 acaagcgagg cgattatgga tcagtttaca gcattaaatg ccgagggaac gacaatcgtt 1506001 ctggttactc acgagcctga agtagcagat tgcacgaatc ggatcgtcat ggtgcgtgac 1506061 ggaaacattg ttcctgccag ctccggacaa aggagtgtgg gagaatgagc ctgttggaaa 1506121 acatcagaat ggctctaagc tctgtccttg cccataaaat gcgttcgatc ttaacgatgc 1506181 tcggcattat cattggtgta ggctctgtca ttgttgtcgt tgcggtagga cagggcggcg 1506241 agcaaatgct gaagcagtcg atcagcggcc cgggaaatac tgtggagctg tactatatgc 1506301 ctagcgacga ggagcttgca agcaacccga atgccgcagc tgaatctacg tttacagaaa 1506361 acgatattaa aggtttaaaa ggaatagaag gcattaaaca agtcgttgct tcgacttctg 1506421 aaagtatgaa agcgcgttat cacgaagaag aaaccgatgc tacggttaac ggaataaatg 1506481 atggatacat gaatgtcaat tctttgaaaa tcgaaagcgg cagaaccttt accgacaatg 1506541 actttctcgc ggggaataga gtcggaatca tctctcaaaa aatggctaaa gagctgtttg 1506601 ataaaacctc ccctctaggt gaagttgtct ggattaacgg acagcccgtt gaaattatcg 1506661 gcgtgctgaa aaaagtaaca ggcttgcttt ctttcgattt aagtgaaatg tatgtgccat 1506721 ttaatatgat gaaatcctct tttggcacaa gtgatttcag taacgtatca ttgcaggtcg 1506781 aatcagcaga cgacataaaa tcggctggaa aagaagcggc acagctggta aatgacaatc 1506841 atggcacaga ggattcgtat caagtgatga acatggaaga gattgcggcc ggaattggca 1506901 aagtaactgc aattatgacg acgattatcg gctcaattgc aggtatttcc cttttggtcg 1506961 gcggaatcgg tgtcatgaat attatgctcg tatcagtcac agaacggacg cgggaaatcg 1507021 gaatcagaaa atcacttggt gcgacgaggg gacagattct gactcagttt ttaattgaat 1507081 cagtcgtatt gacgctgatt ggcggtctgg tcgggattgg tattggatac ggaggggccg 1507141 cgcttgtttc agccattgcg ggctggccgt cactcatatc ctggcaggtt gtatgcgggg 1507201 gcgtgctgtt cagtatgctc attggtgtta ttttcggcat gcttcctgca aataaagccg 1507261 caaagcttga tcccattgaa gcgctgcgtt atgagtagcc tcatgcaaca tgcatgaggt 1507321 ttttttatgt ttagtgattt ctactatgaa tataaaagac ttttttcatt aaaataagaa 1507381 gaaaatgtcg tacaattgtc cttatttttg tcgaatttac agtttacaaa ccctatagac 1507441 atacgttaat atggagaaac gtgaaagatt ttgatagtta ttgaatgaat ttgaatgatt 1507501 ttagttgcct aaaccgaaaa tagcgtttac aatgaaattg tattcaaaat gaatacgttt 1507561 tcattaggag gtgaagcatg ctaactcctg aacggcatca attgattatt gatcaaatag 1507621 aaaagcatga tgtggtaaag attcaagagc ttataaatct gactaatgct tctgaatcaa 1507681 caatcagaag agatttatcg acccttgaag aacgcggttt tttaaagcgc gttcatggtg 1507741 gagcggccaa gctttccgat atcagacttg aacccgatat gcttgaaaaa tcatccaaaa 1507801 accttcacga taaactgaag attgctgaaa aagctgcttc tcttttagaa gaaggggatt 1507861 gcatttacct tgatgcaggc acgacgacat tgcacatgat tgattttatg gataaaacca 1507921 aagatattgt cgttgtcaca aacggggtaa tgcatatcga tgcattaata aggaaagaaa 1507981 tttcttttta tctgcttgga ggatacgtaa agcacagaac gggcgcgatt attggaggcg 1508041 cttcattggt tgccatggac cagtacagat ttgacaagag ttttctgggg acaaacggtg 1508101 tccatacaga ggctggattt acaacgccgg accctgatga ggccctttta aaacagaaag 1508161 cgatcaaaca ggcaaaacac gcttacgtct tagcagaccc ttcgaagttc ggagaaattt 1508221 cattttcggc attcgccgga ataggcgacg caacaatcat tacgactgac gctgaagagc 1508281 ttacattcga taattaccaa gaaaaaactg tcgtaaaggt agtgaaacca tgatttacac 1508341 tgtaacactt aatccatctg tcgattatat agttcacgtt gaagatttta ctgtaggagg 1508401 cctgaaccgt tcttcgtatg ataccaagta tccagggggc aaaggcatca acgtatcgag 1508461 actgctgaaa agacaccatg tggcgtctaa agcgctcgga ttcgtcggcg gatttaccgg 1508521 agaatatatc aaaacatttt tacgggaaga aaacctggaa acagcttttt ctgaagtaaa 1508581 aggggatacc cgtatcaatg taaagctgaa aacgggtgat gaaactgaaa ttaacgggca 1508641 gggaccgaca atttcggatg aagatttcaa agccttttta gaacagttcc aatctttgca 1508701 agagggagat atcgttgttc ttgcaggaag cattccatct tcactccctc acgatactta 1508761 tgaaaaaatc gcagaggcct gcaaacagca gaacgcacga gttgttctgg atatctcagg 1508821 cgaggctctt ttgaaagcaa cagaaatgaa accatttttg atgaagccaa atcatcatga 1508881 gcttggagaa atgttcggca cggccattac atctgttgag gaagccgttc cttatgggaa 1508941 aaagcttgta gaacaaggcg ctgaacatgt aatcgtatca atggccggag acggagcgct 1509001 tctgtttacg aacgaagctg tttattttgc taacgtgcca aaggggaaat tggtaaactc 1509061 agtcggagca ggggattccg ttgttgcagg tttccttgcc ggaatttcca aacagctgcc 1509121 gcttgaagaa gcattccgct taggagttac ttcaggcagt gctaccgcgt tctctgaaga 1509181 acttggaaca gaagaatttg tccagcagct tcttcctgaa gttaaggtca cacgtctata 1509241 gaggaggaaa cacaagtgaa aataactgag cttttaacga agcatacgat aaagcttaat 1509301 attgagagca aagaaaaaga aaatgttatt gacgaaatgg tcactgttct tgataaggct 1509361 ggaaagttaa atgaccgaca agcctataaa gaagccattt taaatcgcga aagccaaagc 1509421 tccacgggta tcggtgaagg aatcgctatc ccccatgcga aaacggcaag cgttatcaac 1509481 ccggcgatcg cgttcggacg ttcaaaagac ggcgtcgatt atgaatcatt agacggccag 1509541 ccggctcact tagtgttcat gatcgcggcg actgaaggcg caaacaacac tcaccttgaa 1509601 gcattgtcaa gactttcaac gctgttaatg cgtgaagaaa tccgtaagca gctccttgaa 1509661 gctgagtctg aagatgccat catcgacatt attaatcagc acgataaaga tgatgacgaa 1509721 gaggaagagg aagaagaagc ggcaccagca cctgccggaa aagggaaaat tttagcggtt 1509781 actgcatgcc cgacaggtat tgcccataca ttcatggctg cggatgccct taaagaaaaa 1509841 gcgaaagagc ttggtgtgga aattaaggtc gaaacaaatg ggtcaagcgg cattaagcac 1509901 aagctcactg cccaagaaat cgaagatgca cctgcaatca ttgtcgcagc ggacaagcag 1509961 gttgaaatgg aacgttttaa aggcaagcgc gtacttcaag ttcctgtaac ggcgggtatc 1510021 agacgtccgc aagagcttat cgaaaaagcg atgaatcaag atgcgccgat ttatcaaggc 1510081 agcggcggcg gttcagcagc ttcaaatgat gatgaagaag cgaaaggcaa gtctggaagc 1510141 ggtatcggaa acacgtttta taagcacctg atgagcggtg tcagcaacat gcttccgttc 1510201 gtagtcggcg gcggtattct cgttgcgatt tcattcttct ggggaattca ctctgctgat 1510261 ccgaatgatc ctagctacaa cacgtttgca gcagcattaa actttatcgg cggcgacaat 1510321 gcattaaaac tcattgttgc agttctggcc ggtttcattg cgatgagtat tgcagatcgt 1510381 cctggttttg cgcctggtat ggtcggcgga tttatggcaa ctcaagcgaa tgctggattc 1510441 ttaggcggct taattgccgg attccttgcc ggttatgtcg tgattttact gaaaaaagta 1510501 tttacgttta tccctcagtc acttgatgga ttaaaacctg ttttgattta cccgctgttc 1510561 ggtattttta tcactggcgt attaatgcaa tttgtcgtca atacacctgt agcggcattt 1510621 atgaatttct taacaaactg gcttgaaagc cttggtactg gaaaccttgt gttaatgggt 1510681 attatcttgg gcggcatgat ggcgatcgat atgggcggtc cgcttaataa agcagccttt 1510741 acgttcggta tcgccatgat cgatgcaggc aactatgcgc ctcatgcagc aatcatggcc 1510801 ggcggtatgg ttcctccgct tggtatcgca cttgcaacaa ccattttcag aaacaaattc 1510861 actcagcgtg accgtgaagc tggtattaca tgctatttca tgggagctgc tttcgtaaca 1510921 gagggagcga tcccatttgc tgcggctgat ccgcttcgcg tcataccagc tgctgtagtc 1510981 ggtgcagctg ttgccggcgg attaactgaa ttcttccgag taacgcttcc ggcgcctcat 1511041 ggaggagtat tcgtagcttt cattacaaac catccgatgc tttacctttt aagtatcgtg 1511101 atcggtgctg tcgtgatggc aattatcctc ggtatcgtca aaaaacctgt tacagaaaaa 1511161 taagaaaaaa agcgtccttg gttcgaaagg acgctttttc ttatccggcc ggcagggagc 1511221 gcggttaagt tatgtatttt attctttttt atgataaagt aaaagaagag aaacaactga 1511281 catagcaatt gtctaggagg aaacactttg accgaggaaa aaaatacgaa tactgagaaa 1511341 acggcgaaga aaaaaaccaa tacgtacctg gaatggggta aagcgattgt catcgctgtt 1511401 ctgctggctc tcctgatccg tcactttttg tttgaaccgt atttagttga aggttcatct 1511461 atgtatccca cattacatga cggagaaagg ctgtttgtga ataaaacagt caactatatc 1511521 ggcgagctga agcgcggaga tatcgttatt atcaacggtg aaacttctaa aatccattat 1511581 gtaaaaagat tgatcggaaa gcctggagaa accgttcaaa tgaaggatga cacgctttat 1511641 ataaacggta aaaaagtagc cgagccttac ttgtctaaaa acaagaagga agcagaaaaa 1511701 cttggtgtca gtctgacagg agactttgga ccggttaagg ttccgaaagg caaatacttt 1511761 gtcatgggag ataaccggct gaattctatg gacagccgaa acgggctggg actgatcgcg 1511821 gaagatcgaa ttgtcggcac atcgaagttt gtctttttcc cgtttaacga aatgcgtcaa 1511881 acaaaataaa aacgccttgc tggcctagga cagcaggcgt ttttattttg aaaaagaagc 1511941 gaccaatgca atgcataaaa ccgtgatgaa cactgaaccg ataatagcca gcacactgaa 1512001 gaaaaggtga acctgtttgt tctcttttcc gcgcttttct aatagccgtt tagaaaaaat 1512061 gtgcgaaaat atgtaaataa gggctatgcc tatatataag ccgatatctt tggcggtaaa 1512121 gcctgttacg gcaaggtaaa agcccgtaaa aaagatcagt aagcaatatt cagtaagtgt 1512181 taaaagcctc aacgtgttcc tccatgagag tgtgtaattt tccaggcgga tgcattctct 1512241 ctctttaatt gtaacacagc tggctggttt gggtgtataa gtgttttctc tctgttttat 1512301 cagggaatca tttctcttgc cctgcattca tggtatactt ttattgatga tagacatgat 1512361 ggaggataat aaatgattgc tgtaaataat gtaagcttgc ggtttgcgga tcgcaagtta 1512421 tttgaagatg ttaatattaa atttacccca ggcaactgct atgggttaat tggtgcaaac 1512481 ggtgccggta aatcaacgtt tctaaaggtg ctgtcaggcg aaatcgagcc tcagacaggc 1512541 gacgtgcata tgagtcctgg cgagcgtctt gccgtcttga agcagaacca ttttgagtac 1512601 gaagagtatg aagtgctgaa agtggtcatt atgggccaca aacgcctgta tgaagtcatg 1512661 caggagaaag acgctattta catgaagcct gatttctcag atgaggatgg gattcgtgct 1512721 gctgagctag aaggtgaatt cgcggaactg aacggttggg aagcggaaag tgaagctgcg 1512781 atcctgttaa aaggccttgg tatctcagaa gatctgcaca caaaaaagat ggcagacctc 1512841 ggcggttcgg agaaggtaaa agttctcttg gcacaggcat tattcggcaa gccggatgtt 1512901 ctgctgctcg atgagccgac gaaccacctg gaccttcagg caattcagtg gcttgaagag 1512961 tttctgatta actttgaaaa cacagttatt gtcgtatccc atgaccgtca ctttttaaat 1513021 aaagtatgta cgcacattgc cgaccttgat tttaacaaaa ttcaaatcta tgtcggaaac 1513081 tatgatttct ggtacgagtc aagccagctg gcgttaaagc tttctcaaga agcgaacaag 1513141 aaaaaagaag agcagattaa acagcttcaa gagtttgtcg ctagattcag cgccaatgcg 1513201 tctaaatcta agcaggctac atcaagaaag aaacttctcg aaaaaatcac gctggatgat 1513261 attaaaccgt cttcccgccg ctatccttat gttaacttca cgccggaacg ggaaatcgga 1513321 aatgatgttc ttcgcgtgga aggcttaaca aaaacaatcg atggcgtaaa ggtgcttgac 1513381 aatgtcagct ttattatgaa tcgagaagat aaaattgctt tcactggccg aaatgaactt 1513441 gctgttacta cgctgtttaa aatcatttcc ggggaaatgg aagctgacag cggaacgttt 1513501 aaatggggtg ttaccacatc tcaagcgtat tttccaaaag acaacagcga atatttcgaa 1513561 ggcagtgatc tgaaccttgt agactggctt cgccaatatt ctccgcacga ccaaagtgag 1513621 agctttttac gcggtttctt aggacgcatg ctgttctctg gagaagaagt ccacaaaaaa 1513681 gcaaatgtac tttccggggg agaaaaggtc cgctgtatgc tgtcgaaagc gatgctttct 1513741 ggcgccaata ttttaatttt ggatgagccg accaaccatt tagacctaga gtccattaca 1513801 gcgctcaata acggcttaat cagctttaaa ggcgctatgc tgtttacttc ccatgaccat 1513861 cagtttgtgc agaccattgc caacagaatt atagaaatta cacctaacgg catcgtcgat 1513921 aagcaaatga gctatgacga gttccttgaa aatgctgatg tgcagaaaaa attgactgaa 1513981 ctatacgccg aataaaaaag cagagatttc tctgcttttt ttgataccta aatgtgaaag 1514041 gagatcacaa catgaaattt ttggttgtcg gagcaggtgg agtaggcggg tatattggcg 1514101 gacggctttc ggagaaagga aatgatgtga catttctcgt gcgccaaaaa cgagctgagc 1514161 agcttaaaaa aaccgggctt gtcatccata gtgaaaaagg gaatgtatca tttcagcccg 1514221 aactaatcag tgccggagaa acagggcaat ttgatgtcgt tatcattgct tctaaagcat 1514281 actcgcttgg tcaagtgata gaggatgtca aaccatttat ccatcaagaa tctgtcatta 1514341 tccctttttt aaatgggtac cgccactatg agcagctatt tgcggcattt tcaaaagaac 1514401 aggtgctggg cggcctgtgt tttatagaaa gtgctttaga caacaaagga gaaattcatc 1514461 atacgagcgc atcgcatcgt tttgtatttg gagaatggaa cggcgagcgt acggagcgga 1514521 taagagcgct tgaagaggca ttttcaggtg tgaaggctga agtcatcatt agcgggcata 1514581 tcgagaagga catttggaaa aagtatctct ttattgcagc gcaagcgggg atcacaacgt 1514641 tatttcaacg accgcttggc ccaatcctcg ccacagaagc cggacgtcac acggcccaaa 1514701 ctcttattgg ggaaatttgc actgttttac gaaaagaagg tgttccggct gatccggctc 1514761 ttgaggaaga gagctttcgt acgatgacca gcatgtctta ccatatgaag tcctccatgc 1514821 ttcgggatat ggaaaacggc caaacgacag aaggcgacca cctgcatgga tttttgattg 1514881 aaaaagcaaa acgtttatct ctcgctgcac cagtattaga aaccgtttat gcgaatctgc 1514941 aaatgtatga agcagaaaaa taaaaaaagg aggcggaaaa gcctcctttt atttacttaa 1515001 aaagcccaat ttccgtttct gaagataggc tctcttttcc cgtctgccgt aattccgtca 1515061 atattcatat ccttagaacc gatcataaag tccacgtgtg taatgctttc atttaggcct 1515121 tctttgacaa gctcttcacg agacatctgc tttccgcctt caatattaaa ggcataggcg 1515181 cttccgatcg ccaaatgatt tgacgcgttt tcatcaaaca gcgtgttata gaaaagaatg 1515241 tttgattgtg atataggcga atcgtaagga acaagtgcca cttcacctaa atagtgagaa 1515301 ccttcatctg tttccaccag ttcttttaaa atatcctcac ctttttcagc tttaatgtcg 1515361 actatacggc cattttcaaa cgtcagggtg aaattttcaa taatatttcc gccgtagctt 1515421 aatggttttg tgcttgatac cactccgtca accccgtctt tttgcggcag cgtgaacact 1515481 tcttctgtcg gcatattggc cataaactca tggccacttt cattcacgct tcccgcacct 1515541 gcccaaacat gcttcctagg cagcttaatt gttagatcag ttccttctgc ttgataatgt 1515601 aaggcagcgt aatgtctctc gttcaaatgg tcaacttttt catgaagatt ttggtcatga 1515661 ttgatccacg cctgaaccgg gttgtcttca tttacgcgcg tcgctttaaa aatttcttcc 1515721 cacagaaggt ggatcgcttc ctcctctgat ttgccaggaa acaccttgtg agcccagcct 1515781 gctgatgccg cacctacgac agtccagctg actttgtctg attgaatata ttgtctgtat 1515841 gtatgtaatg ctttgcctgc tgctttttgg aatgccgcaa tccgtttgga atctatacct 1515901 tttagcaagt ctgggttcga cgacacaaca gaaatgaaag cagctccatt tttggcaagc 1515961 tcttctctgc cttttgcttc ccattcagga tattcttcaa atgcttcaaa cggcgcaagt 1516021 tcgtatttta atttggcgac ttcgtcatcc tgccaattca cggtgacgtt ttttgcgccc 1516081 ttttcatatg cgtgttttac aattaaacgg acaaaatccc gaacgtctgt tgaagcattt 1516141 acgactacat actggccttt ttggacatta acgccgactt ctaccgccag ctgtgcatat 1516201 gtatttaatt tctgtgaaaa tgaatccatg aatcattcct ccaagctttt ttctcatcat 1516261 atcaaatatg atcctataaa ggaaagaagg agcccaaagt gaaaaaccca aaacgacacg 1516321 tcttgggttt tttcaatatt atggatgatt cagttttaca gtgccgcctg caggcgaatg 1516381 gggcatattt gccaaagaaa tgctcatgcc tccaagaata attccgctta aaatggctgc 1516441 gatcgctact cttcttccta aatctcttag catctgtttc ctccttaacg tttctccatt 1516501 tcccacaata tgaaggaagt gaggaaaaaa gaagcaagaa atttgccgcg tgtgagaatt 1516561 ttgcgggtaa agactattta attgcctttt gcagcttatc aatcacttct aaagaacggc 1516621 ctgtgccgat tgctacagat tcaagcgggt tttgcgccac gtgtacaggc acgacaatct 1516681 cttctgtgag ccattcttta attccattaa ggagcgcgcc gccgcctgtt aaaataacgc 1516741 cgcgatcaac aatatctccg ctcaattcag gcggacagtc ctcaagtgtc gctctgatgg 1516801 cttcaagaat atgcaggagg gattcacgca ttgcatcttg aatttcgttg gattgaagca 1516861 taatggtttt tggaagacct gtcacgaggt cacgtccccg aatttccatt gcctctggta 1516921 tatgttcaat cagagcatgg ccaatttcca tttttacctg ctcagctgtg cgttcgccga 1516981 tcagcaaatt gtatttttta cggacgaaag aaacgatatc ctcatcaagc tggtctccgc 1517041 cgatcctgat agaatggcag gaaacaacgc caccgaagga aataatagcg acctctgtcg 1517101 tccctccgcc gatatctact accacattgg caaccggctc atcaaccggt aaatccgctc 1517161 cgatggcggc tgcaactggc tcttcgatta aatgaacgtt tttcgcgccg caatttttca 1517221 ccgcatcact gatggcgcgg cgttctactg ctgttgagcc tgatggtgtg caaacgacta 1517281 cgttcggttt tctgaacgac atgccgatgc tttttgcggc ttttttcata atgtgcttta 1517341 gcaggtcagt tgtcatatca tagtctgcga tcacgccatc tttcatcggt ctgacagcga 1517401 caatttttcc cggtgtttta ccgatcatgt ttttcgcgtc agctccgatt gcaagcactg 1517461 cttttgtcgt cgtatccact gcgacaacag atggttcatt taggataatc cctttatttt 1517521 tgctgtaaac aagtatatta gctgttccta agtcaatccc gatttcagtt gattgaaaca 1517581 tgttttcacc caatctctat cctaatttaa tatgattcta catttaaagt ttctcagaaa 1517641 tactgcgatt tttgggggtg tgcgtcggta aagaaatgtt tttgtaaaaa atcaaggaac 1517701 tgtgtaacag aagtaataca tttttcggtt ttatggaaaa aatatcttgt aattcttata 1517761 gaaagcggga aactttttca aagtttcatt cgtctacgat atattgaggt acatccttaa 1517821 aacattacat gagaaaagaa acatttaaag gaagaagggt ttttatgaaa tcaataggtg 1517881 ttgtgagaaa agtagatgaa ttaggccgca ttgtcatgcc gattgagttg agacgggcat 1517941 tggatattgc cataaaagac agcattgagt tttttgttga cggagataaa attatcttga 1518001 aaaagtacaa acctcatggc gtttgtttaa tgactggaga aatcacttca gaaaataaag 1518061 aatacggcaa cggtaaaatt acgctaagcc ctgagggtgc acagctgctt ctcgaagaaa 1518121 ttcaagccgc tttaaaagaa taaaattatg ctaaaaaagg cggagtgata tcatctccgc 1518181 cttttttgcg tgccaatttt tgattaccgc cgcctaagat aagacatcaa gatatttggt 1518241 aatgaatgat ttgggatact ttacatattt tactcaatta tttgtcgaag aatggtacaa 1518301 taagtagaga aacacaagcg gcaggtggtc atatgagaaa atatcaagct cgtatcattt 1518361 ccatcatttt ggcaatgatt tttataatgt tttgggatta tttattttat tttataggca 1518421 aaaacccgat taattggcct gttgatattg tgtatactgc agtcacgctg gtaagtgtct 1518481 ggatgttggc ttattatatt gatgagaaac agcagctggt taagaaaatg aaggataacg 1518541 aatggaagta taaacagctt tctgaagaaa aaaaccgcat catggataat ttgcaggaaa 1518601 tcgtatttca aacgaatgca aaaggtgaaa ttacatattt aaaccaagcg tgggcatcta 1518661 taaccgggtt ttcaatcagt gaatgtatgg gaacaatgta taacgattac ttcataaaag 1518721 aaaagcacgt agccgaccac attaacaccc aaatccaaaa caaagcgtct tctggcatgt 1518781 ttacggcaaa atacgtgaca aaaaacggca cgattttttg gggagaagtt cattataaac 1518841 tttactatga ccgggatgac caatttacag gcagcctggg tacaatgtca gatatcactg 1518901 agcggaaaga ggctgaagat gagctcattg agattaatga acggctggcg agggaatccc 1518961 agaaactatc aatcacaagt gaacttgccg caggtattgc tcatgaggtc agaaaccctt 1519021 taacatctgt cagcggtttc ctccagatta tgaaaacaca atatccggac agaaaagact 1519081 attttgacat catcttttca gagattaaaa gaatcgattt agtgctcagc gagctgctgc 1519141 tgcttgcaaa accgcaggca atcacattta aaacacacca gcttaatgag atcttgaaac 1519201 aagtcacgac attgcttgat accaatgcaa ttctgtccaa tatcgtcata gagaaaaatt 1519261 tcaaagagac agatggctgt atgattaatg gagacgaaaa tcagctgaag caggtcttta 1519321 tcaacatcat taaaaacgga attgaggcaa tgccaaaggg cggtgtcgta accatttcaa 1519381 ctgctaaaac cgcctctcat gcagtgataa gcgtaaagga tgaaggaaac ggcatgccgc 1519441 aggaaaagct gaagcagatt ggcaaacctt tttattcaac aaaagaaaag ggcactggac 1519501 tgggacttcc catttgtttg agaatcctga aggaacatga cggggaattg aaaatcgaaa 1519561 gtgaagctgg aaaaggcagc gtctttcaag tggttttgcc tttaaaatca gacagctgag 1519621 aggagaaaaa taaagtgaac tcgcttctgt ttgtatacgg gacattaaga aagcatgaaa 1519681 aaaaccatca tttgctggca caatcggcat gtatcaatga gcaggcgaga acaaagggaa 1519741 gtttgtttgc tgcaaaagag gggcccacag ttgttttcaa tgatgaagat gaaggctata 1519801 tatatggcga agtatatgaa gcagatgaat tgtgtataca taagctcgat caattttttc 1519861 aaggatatca taaacaaacg gtgtttgtag aaacggatgt cgggattaaa attgcgctta 1519921 tttattttat gaacaaagac gggtgtgccg gttttacgaa aataagcagc ggcgactgga 1519981 aagaacatca gatgatcagc aaatcgaaaa atcccattta ttattttgcc tatggatcat 1520041 gcatggataa tgcccgcttt caaaaagcgg gagtcgatca ctattttcaa gatccagtag 1520101 gaagagctgt tttaaaagga tacacaaccc gcttcacgct aaaaagggaa gacggttcaa 1520161 gagcggacat gttggaagac ggaggaacaa cagaaggcgt tttataccgt atcccttatt 1520221 ctgctctctc ctatctatat aaaagggagg gcgtcgaatc tcttacgtat cggccggcat 1520281 ttgtagacgt tgaagctggc ggaaggcact acaaagactg tttaaccttt ctcgtcctcc 1520341 aaaaagaagc ggaaattgcc ccgcctcagc actatcagat tgaaatcgaa cgcggagcgg 1520401 agctgtattt gtcgcctgag tttactgaaa agctcaagcg gcatatgaat tcgctgccaa 1520461 aaggataaca ctgtaacaaa agaatatgat aaaatttgat caatatcatg tcatataaag 1520521 gagcaccacg atgaaaaaag aatttgcggt aattgggctg ggccgttttg gtggcagtat 1520581 ttgcaaagca ttaagcgaag aaggcgtcga ggttatggca atggatatcg atgaagataa 1520641 agtcaacgag tatgccaaga ttgcatctca cgcagttatc ggtgattcga cagacgaatc 1520701 tgtcctgaaa aatttaggcc tgcgaaattt tgaccacgtt attgtagcaa tcggggaaaa 1520761 tattcaagcg agtattttaa cgacactcat tctgaaagaa cttggcgtcc atacgattac 1520821 agttaaagcg cagaacgatt atcacgaaaa agtgctgtct aaaattggtg cggatcacat 1520881 cgtccacccg gaacgcgata tggcaaaacg aattgcgcat aatatcgtgt ccaacaatgt 1520941 acttgactat ttggagctgt ctgaagagca tagtcttgtt gaaatcgtag ctaacagccg 1521001 cctggctgga aatacgcttc tcgatttaga tattcgcgca aaatacggta ttaacatcgt 1521061 agccataaaa aggggcaagg aagtcatcgt atcaccgctt gcaaccgaag tcatccacca 1521121 agaagatata ctcattgtta ttggatcagt tacagacatc tcccgtttcg aaaaaagagt 1521181 tcttcataca aaatagcagc caaataagcc gtcctcaaag ggcggttttt catattatca 1521241 gaatataaca actttaatga actgagcgtc aatttcttaa aatttcattg actaagcaca 1521301 ggcgttccga tagcatattg taccatataa taaaaaaagg aggggcctat ttgaataaag 1521361 aagcgctagt caataggctg aatgcttcag ccaaaagaca aaaagctgat atcgtcatta 1521421 aaaacggaaa aatcatggac gtatataatc aagaatggat atatgaagat attgcgatta 1521481 cagatggagt tattgtaggc ctcggtgagt atgaaggcga aaatatcatt gatgcagagg 1521541 gacaaatgat tgttccgggt tttattgatg gacatgtaca tattgagtcg tcaatggtta 1521601 caccgattga gttcgctaaa gcagtgttgc ctcatggcgt gacgacggtt gttacagatc 1521661 cgcatgagat cgcgaatgtg tctggtgaaa aagggattga gtttatgctt gaacaagctc 1521721 ggcatacacc gctgaatatc cattttatgc ttccttccag tgtgcctgcc gcaagttttg 1521781 agcgatcagg cgcaattctc aaagctgccg atctcaagcc tttttatgaa gaagaagaag 1521841 tattagggct ggctgaagtt atggattatg tgtcggttca gcaggctgaa aaagacatgg 1521901 ttcagaaact gcttgatgcc cgtgtggcag gaaaaaggat agacggtcat ttagctggtt 1521961 tatcaacaga cctcattaac atttacagaa ccgcatttgt cttaaacgac catgaagtaa 1522021 catcgaagga agaagccctt gatcgtatca gaaggggcat gtatgtcatg atgcgtgaag 1522081 gatcagtcgc caaaaacacg ctcaatgtgc tgccggcggt gaatgaaaag aacgcacgcc 1522141 ggttcttttt ctgtacggat gataagcatg tggatgattt attgtcagag ggaagtgtaa 1522201 accatcaggt gaaaatggcg attcaagccg gacttaatcc gtttttagcc tatcagctag 1522261 gaagcctcaa tgcagccgaa tgctacggat tagatacaaa gggagcgatt gccccgggtt 1522321 ttgacgctga tttgcttttt gtatctgatc tggaaaatgt cactgtcaca atgacgatgg 1522381 taaaagggca gactgttgct gaagacagca aagcggtcta tcaggatcat gcttcaactg 1522441 cagcaccaga tcaggcactg cttgattctg ttaagcttgc tgctcctctt aacaaacagg 1522501 attttcatat gccaatcgat tcagagcagc agatcaatgt cattcaaatc ataccaaatc 1522561 agcttgaaac acgattagta caagttccgg ctcctgttgc ccgcgaattt gagcctgaca 1522621 ctgagcttga tttgttaaag attgcagttg tcgagcggca taaaggatta aaagaaaccg 1522681 gacttggtgt tgtgaaaggt tttggattca agagcggagc gattgccaca accatttcac 1522741 acgactccca taatattatt gccgtcggaa cgaatgatga ggatatcgcg gcggcagtta 1522801 ataagctgca ggaaattggc ggaggattaa caattataaa aaatggggaa gagctccatt 1522861 cagtaccgct gccgattgca gggttattat ccgaccaatc tgcagagcaa gtgaatcaaa 1522921 gcttgctgac gcttcatgat aaattgtcgt taatcggttt cacaggcgga tttaatccat 1522981 ttttgacatt gtcgttttta gcgttgcctg tcattcctga tattaaaatg acgactacgg 1523041 gattattcga tgtaaaatca tttcaacaca tatcactgca ataaaaagag gcactccctt 1523101 agggagtgcc tcttttttta aacctccata atgatcggca ggatcattgg acggcgcttt 1523161 gttttttcgt acaagaaagg tgcaagcgtg tctgtaattt cgtttttgat ttcagaccat 1523221 tgagtcgttt ttcgttccat tactttttgt aagtgatttg aaatgagctc ttgagcgtcg 1523281 ttgatcaagt caccagattc tctcatgtac acaaatcctc tggaaatcaa atcaggaccc 1523341 gctgaaatct tgaagtcgtc catgtcaatg ctgacaacaa cgatgacaag tccttcttca 1523401 gagagaattc tgcgatcacg aagtacgata ttgccaatat caccgatacc gcttccgtca 1523461 atgtacactg aaccggacgg gatttttcct gcaactgaag cctcatcgcc tttaagtgct 1523521 aatacttcac cattatccat gataaagcag ttttcctctg ggatgccaca atctgttgca 1523581 agtttgacat gcatcttttg cattctgtac tcaccgtgaa tcggcatgaa gaatttaggc 1523641 ttgattaaac gaagcatcag cttctgttct tcctgtccgc cgtgaccgga tgtatggata 1523701 tcgttaagag ggccgtgaat aacctcagca cccgcacgat acagctggtt gattgttcga 1523761 ctcacgctga ttgtgttgcc tgggataggg gatgaagaaa atacgactgt atccccagga 1523821 ttgattgaaa tttggcggtg tgtgccgttt gcaattcttg ataacgccgc cattggttcc 1523881 ccttggcttc ctgtacataa aattgttact ttattagcag gcatacgatt gatttcgtta 1523941 tgctcaataa acgtattttt aggacagtta atataaccga gtgtctgtcc aatttcgata 1524001 gccgattcca tactgcgtcc aaatacggca acttttcttc cattttgtac agcagcttca 1524061 attacctgct gcaagcggtg aatattcgac gcaaatgtgg cgaagataat tcggccgtcc 1524121 accttgcgga aaatgtcatg aatgctttct cctacacggc gctcagacat ggtaaactcc 1524181 ggattttcac tgtttgtgct gtctgaaaga aggcacaaaa cgccttcttt accgatttcg 1524241 gccattttcg ttaagtttgc cggctcgccg actggagtaa agtcgaattt gaaatcccca 1524301 gtatgtacga tgtttccggg cggcgttttt acaacaatgc cgtaggaatc cggaatactg 1524361 tgtgttgttc tgaagaatga cacagccgtt ttgcggaact ttacaatatc atcctcgccg 1524421 ataatgttca gtttcgtctg tctcaataat ccatgctctt caagtttatt ccgaagtaag 1524481 ccgatcgcga gttttccgcc gtatacagga atattcactt gtctgagcag gtatggaata 1524541 ccgccgatgt ggtcttcgtg cccgtgggtg ataaaaagcc ctttaatttt atcttcgttt 1524601 ttgactaaat acgtataatc agggatgacg tagtcaattc cgagcagttc gtcctcggga 1524661 aacttgatcc ccgcatcaat cagtacaatt tcatcctgga attgcaccgc gtacgtattt 1524721 ttaccgattt cgcccaaacc tccgagggcg aaaacagcag tctgatcatt ttttacaaat 1524781 ttcataccgc tcataactcc aatactttaa aattttcgct ctgttgttca tattctaaga 1524841 atgcaccatc aacaggtgta ataaactcaa tattaaattt cttttctttc agctttgttc 1524901 tgacgtcacg ctcagatacg ccttcaatat aaagtgaatc tgtcttttcc cgaacaggta 1524961 cttcgtcagc cttctcttga taaaatacct tataaatcat tccaaatctc tccttaaatg 1525021 ccgtatgtta gactcgctca ttctattata ttcgaaaacg gaatataagg aaagccttga 1525081 gcaaaataag gatctctcaa aaagtgaaag atcccttgtc aggcaattgc tttcttacgg 1525141 agcattccgt tccattgtct tctgagtttc tttcttaatt tacgcagcat tagccagtcc 1525201 ctcctttaat gaaaaatttg tcccagagtt cttttataca aatagtatac ggagattgag 1525261 gaagactttt cgtggttatt aatggaattt aatatgattt ttgaacgaaa ttgtttgctg 1525321 aatgacaatc tttttgtatg atgagggtgg gaattgcaga ccaagacgat aaaggggaag 1525381 ttgcgatgga ttctaaatta atcttttttg atattgacgg cacaatatat gatcatgata 1525441 agaatatacc ggaaagtacg agaaaaaccg tggcggagct tcagcgccaa gggcatcatg 1525501 tgtttattgc cagcggccgg tctccatttt tggttaagcc gattttggag gagctgggca 1525561 tccactcatt tatttcctac aatggacagt ttgttgtctt tgaaaatcaa gtgatttata 1525621 aaaatccgct gcctgaaaat gcaatcaggc gattattaaa gcaggcggat gaaggcaagc 1525681 atcctgttgt gtttatggct gaggacacga tgaaagcgac tgttgcggat cacccccatg 1525741 ttctcgaggg aatcggcagc cttaaaacag attatccaga gaccgatgac cttttttatg 1525801 aaggaaaaga aatttttcag cttcttttat tttgtcagga tgaagaagaa aaagcttatg 1525861 ccgcttttcc tgagtttgat ctagttcgct ggcatgagct atcgactgat gttctgccgc 1525921 acggaggttc gaaggcagaa ggaatcaaaa aagtgattga gcgtcttccg tttgatatcg 1525981 gcgatacata tgctttcggc gacggattaa atgatttgca aatgattgaa tacgttggga 1526041 caggcgttgc tatgggaaat gctgttcccg aactgaaaga aatcgcggac tttgtaacaa 1526101 aaccggtgga cgaggatgga attgcatacg ctgtcaaaga attgggcctt ttaaaataaa 1526161 gaaacggctg gcattgtgcc agccgttttc tcttttagcg ctcaattgcg attgcatttt 1526221 caggttcttt gaaaggattt tccttatcaa tatgatcata gaacataacg ccgttcaaat 1526281 gatcgatctc atgctgaaac acaatagccg gaaatccttt taaacgaata tcaatatttt 1526341 cgccttctag tgttgttcct tttactctga tgcgagcata gcggggaaca taaccgggaa 1526401 tcgcttcatc cacagagagg cagccctcgc cgcttgttaa gtagcttttt tcaactgaat 1526461 ggctgacgat cttaggatta aacagagcat agctgtataa tttaccggaa gcatcttccg 1526521 catgaacggc gatcattcgt tttttgatat taatttgagg agctgcgagt cctacgccag 1526581 ggcgcagctt gtatttttcg gctaattctg gattttggct gtttttaaca aattcgatca 1526641 tgtcggccag ctgctgtttt tctgcatcag ttggaggcag ctcaacaggt tcggcagtct 1526701 ctctgagggc tggatggccg tcacgtacga tgttttccat agtaatcaag aaacttcact 1526761 cctaaagctt aatatgtaaa ttatatcgga tttcttcaca aaggtgcaac gaaacgaatg 1526821 accagccgta tatggctggt caatttcatg ctgtgtggtt agcaacagcc tccacctaaa 1526881 taagcagctc cgacaatgat taacagaatg aataaaacaa cgattagcgc aaaggtgcgg 1526941 ccgtagccat atccgcagcc accatatccg taaccaccat aactgcagca gcctccgccg 1527001 taaccatatc catacatatt acataacctc ctcttttaat tacgccagag cctttataag 1527061 taggcatagc gtctaatata acctatgtaa aaacaaaaaa gttgtatggt catctgtcct 1527121 gatttttcac ttttttgatt taatttcagt attgcattta tacagcacgg ctattgccaa 1527181 atgtccccat ggattctata gtagaaattg tcaagattgg gggatttaac gtgaaagacg 1527241 ctataaaacg gcggcctgga atcaagatcg gagctttttg tgccatggca ctgatattaa 1527301 caggatgcat gggacaggac ccggttgatt cacttcatca ttcattagaa aaagccgcgg 1527361 aatcggaaaa gccgtttcaa gaagaacaaa acacactcaa agaattagag gccaaagaaa 1527421 atcagcttta cgatagtgtt atgaagctca atatggatga ttataaaaaa attgttgctt 1527481 tatctaataa ggcgcttgaa aatgtcagca agcgcgaaga acacctaaag cttgaaaatg 1527541 acagcatgaa aaaatcggaa acagaatttg aggaagcaaa aacgtcagcg gaacatatta 1527601 aggaaaaaga cataaaagaa aaggccgatg ccgcagcaaa ccatatggag aaaagatata 1527661 catcatatgg cactatgtat aaagagtata aaaaagcgct tgagcttaat aaaaaactgt 1527721 atatgcagct gaaagacaaa gatttgacaa gagatgatct ggatcagcag atcgataaag 1527781 tcaatgcttc ttatgaaaag atccttaaat atagcggaga atttaatgaa caaaccgaaa 1527841 aatataataa agcccgggaa gatttatatg atgctgcagg ctatcgtgtg aaaaagagct 1527901 gactcgatca gctctttttt tgaatgaaat gcgattcgga tttcgttcaa aattttcatt 1527961 tctattgtag tacagcatag taaggtatac tagtacagtt ttgggtgcgg ttggcatctg 1528021 tttttttgat gaaaatgtaa agcgaataca tttattgaaa atcagcgatg aaaacgattg 1528081 acggttcttc tttatttggt gtaaactaat ccatgttaag cggtgttgta ttagtttttt 1528141 acaacttcga aataatacag ttcaaagcag agtgtaacta tcctacataa aaggttttgg 1528201 caaactgggg atcggctaaa atataatacg acttactgct gatactttag ggtaccctaa 1528261 gtttgtatgt ataaaaggaa tgcacgtcta atgactgttt aaaagaaagg aagaggtgac 1528321 ttagtatggc tgcaaaaacg aaaaaagcta tcgttgacag taagaagcaa tttgatgcca 1528381 ttaaaaagca gttcgaaacg ttccaaattt taaatgaaaa gggagaagtc gtgaatgaag 1528441 cggcgatgcc tgatttaact gatgatcaat taaaagagct aatgcgccgc atggtattta 1528501 cgcgtgtgct tgaccaacgc tctatctcat taaaccgtca aggacgtctc ggattttacg 1528561 ctcctactgc gggtcaagaa gcttctcaga ttgcaacgca tttcgcgctt gaaaaagaag 1528621 actttgttct tcctggatac cgtgatgtgc ctcagttaat ttggcacggc cttccattat 1528681 atcaagcgtt tcttttctct cgcggacatt tcagaggaaa ccaaatgcct gatgatgtga 1528741 atgccctttc tccacaaatc attatcggtg ctcaatacat tcaaactgcc ggtgttgcgc 1528801 taggtcttaa aaaacgcggt aagaaagctg tcgcaatcac ttacactggt gacggcggag 1528861 cttctcaagg ggacttctac gaaggaatta actttgccgg agcttataaa gcacctgcaa 1528921 tcttcgtggt gcaaaacaac cgttacgcga tttcaactcc tgttgaaaaa caatctgcag 1528981 ctgaaacaat tgcacaaaaa gctgtagctg ccggtattgt cggcgtacaa gtagacggaa 1529041 tggatccgct tgctgtatac gcagcaactg ctgaagcacg cgagcgcgca atcaacggcg 1529101 aaggtccaac actaattgaa acacttacat tccgttatgg cccgcacaca atggctggtg 1529161 acgatcctac taaatatcgt acaaaagaaa tcgaaaatga gtgggaacaa aaagatccgc 1529221 ttgtacgttt ccgtgcgttc cttgaaaaca aaggcttatg gtctgaagaa gaagaagcaa 1529281 aagtgattga ggatgcgaaa gaagaaatta agcaagcgat caaaaaagct gatgctgaac 1529341 cgaagcaaaa agtaactgat ttaatgaaaa tcatgtacga aaaaatgcct cacaaccttg 1529401 aggagcaatt tgaaatttat acacagaagg agtcgaagta agccatggcg caaatgacaa 1529461 tgattcaagc aatcacggat gcgttacgca cagaactgaa aaatgacgaa aatgtcttag 1529521 ttttcggaga agacgttggt gtaaacggcg gcgtattccg tgcgacagaa ggattgcaaa 1529581 aagaattcgg tgaagaccgt gtgtttgaca cgccacttgc tgaatctggt atcggcggtc 1529641 ttgcccttgg tttaggctta aacggcttcc gtccggtaat ggaaatccaa ttcttcggat 1529701 ttgtttatga agtaatggat tcagtttctg gccaaatggc tcgtatgcgc taccgttctg 1529761 gcggacgctg gacttcacct gtaacaattc gttctccatt cggcggcggt gttcatactc 1529821 ctgaacttca cgctgacagc ttggaaggtc ttgttgcaca acagcctggt atcaaagttg 1529881 ttattccatc aactccttac gatgccaaag gacttttaat ttctgcgatc agagacaatg 1529941 atcctgttgt cttcttagag catatgaagc tttaccgttc tttccgtcag gaagttcctg 1530001 aagaagaata cacaattgag cttggaaaag ctgacgtgaa acgtgaaggt actgatcttt 1530061 caatcatcac ttacggcgca atggttcatg aatcattaaa agctgctgat gagcttgaaa 1530121 aagacggcat ttctgctgaa gttgtcgacc ttcgtacagt aagcccactt gatatcgata 1530181 caattatcgc ctctgtagaa aaaacaggac gcgcgattgt cgttcaagag gcacaaaaac 1530241 aagccggtat tgctgcaaac gtagtagcag aaattaatga ccgtgcgatc ctgagcttgg 1530301 aagcacctgt acttcgcgtt gcagcgccag atacagtatt tcctttctct caagcggaga 1530361 gcgtatggct tccaaaccat aaagacgttc ttgaaacagc aagaaaagtg cttgaatttt 1530421 aatcaaactg cataatcgag agggaagatg aacgttttcc ctctattata tatctgtttt 1530481 caatgcttac gatgtaaact ttaaaattgc ttaatcaaac taggaggtcg agaactgtgg 1530541 catttgaatt taaacttcca gatatcgggg aaggtatcca cgaaggcgaa atcgtaaaat 1530601 ggtttgtcaa gcctaacgac gaggtagacg aagatgatgt actggctgaa gtccaaaatg 1530661 ataaagcagt agtagaaatt ccttcacctg ttaaaggaaa agtattagaa ttaaaagttg 1530721 aagagggaac ggttgcaact gttggacaaa cgattattac gtttgatgca cctggttacg 1530781 aagatcttca atttaaaggc agcgacgagt ctgacgatgc gaaaactgaa gcacaagttc 1530841 agtcaactgc agaagctgga caagacgttg cgaaagaaga gcaagctcaa gagcctgcaa 1530901 aagctactgg cgcaggacag caggatcaag ctgaagttga cccgaacaaa cgcgtgatcg 1530961 ctatgccttc cgtacgtaaa tatgcacgtg aaaaaggtgt agacatccgt aaggttactg 1531021 gttcaggcaa caacggacgt gttgtaaaag aagatatcga cagctttgta aacggaggag 1531081 cgcaagaagc tgcaccgcaa gaaacagctg caccacaaga aacagctgct aaaccggctg 1531141 ctgcaccagc tccagagggc gaattcccag aaacacgcga aaaaatgagc ggtatccgta 1531201 aagcaattgc aaaagcgatg gttaactcta aacacactgc tcctcacgta acgttaatgg 1531261 acgaagtgga cgtaacaaac cttgttgcac atcgtaaaca gttcaaacag gttgctgctg 1531321 atcaaggaat caagctgact tacttgcctt acgttgtaaa agctcttaca tctgcactga 1531381 aaaaattccc tgttttaaac acgtcaattg acgataaaac agatgaagtc atccaaaaac 1531441 attacttcaa catcggtatc gctgctgaca ctgaaaaagg cttgcttgta ccggttgtga 1531501 aaaatgcaga tcgtaaatct gtctttgaaa tttctgatga aatcaatggc cttgcaacaa 1531561 aagctcgtga aggcaagctt gctccagctg aaatgaaagg cgcatcttgc acaattacaa 1531621 acatcggttc tgccggcgga caatggttca ctccggttat caaccatcca gaagttgcga 1531681 ttcttggtat cggacgcatt gcagaaaaag cgattgttcg tgatggcgaa atcgtagcag 1531741 ctccagtctt agctctttct ctcagcttcg accaccgtat gatcgacgga gcaactgcgc 1531801 aaaatgcatt aaatcacatc aagcgtttac tgaacgatcc acaattaatt ttaatggagg 1531861 cgtaatgtta tggtagtagg agatttccct attgaaacag atactcttgt aattggtgcg 1531921 ggacctggcg gctatgtagc tgccatccgc gctgcacagc ttggacaaaa agtaacagtc 1531981 gttgaaaaag caactcttgg aggcgtttgt ctgaacgttg gatgtatccc ttcaaaagcg 1532041 ctgatcaatg caggtcaccg ttatgagaat gcaaaacatt ctgatgacat gggaatcact 1532101 gctgagaatg taacagttga tttcacaaaa gttcaagaat ggaaagcttc tgttgtcaac 1532161 aagcttactg gcggtgtagc aggtcttctt aaaggcaaca aagtagatgt tgtaaaaggt 1532221 gaagcttact ttgtagacag caattcagtt cgtgttatgg atgagaactc tgctcaaaca 1532281 tacacgttta aaaacgcaat cattgctact ggttctcgtc ctatcgaatt gccaaacttc 1532341 aaatatagtg agcgtgtcct gaattcaact ggcgctttgg ctcttaaaga aattcctaaa 1532401 aagctcgttg ttatcggcgg cggatacatc ggaactgaac ttggaactgc gtatgctaac 1532461 ttcggtactg aacttgttat tcttgaaggc ggagatgaaa ttcttcctgg cttcgaaaaa 1532521 caaatgagtt ctctcgttac acgcagactg aagaaaaaag gcaacgttga aatccataca 1532581 aacgcgatgg ctaaaggcgt tgaagaaaga ccagacggcg taacagttac tttcgaagta 1532641 aaaggcgaag aaaaaactgt tgatgctgat tacgtattga ttacagtagg acgccgtcca 1532701 aacactgatg agcttggtct tgagcaagtc ggtatcgaaa tgacggaccg cggtatcgtg 1532761 aaaactgaca aacagtgccg cacaaacgta cctaacattt atgcaatcgg tgatatcatc 1532821 gaaggaccgc cgcttgctca taaagcatct tacgaaggta aaatcgctgc agaagctatc 1532881 gctggagagc ctgcagaaat cgattacctt ggtattcctg cggttgtttt ctctgagcct 1532941 gaacttgcat cagttggtta cactgaagca caggcgaaag aagaaggtct tgacattgtt 1533001 gctgctaaat tcccatttgc agcaaacggc cgcgcgcttt ctcttaacga aacagacggc 1533061 ttcatgaagc tgatcactcg taaagaggac ggtcttgtga tcggtgcgca aatcgccgga 1533121 gcaagtgctt ctgatatgat ttctgaatta agcttagcga ttgaaggcgg catgactgct 1533181 gaagatatcg caatgacaat tcacgctcac ccaacattgg gcgaaatcac aatggaagct 1533241 gctgaagtgg caatcggaag tccgattcac atcgtaaaat aattttcata tcaaaaacag 1533301 ccccgctttg agcgagggct gtttttttat tttgacagca catgctgtaa tggtttaatg 1533361 atgtcttctt tctttttcac acatccctcg attttcacca cgacatggcg ctgatcaaca 1533421 accataaggg tagggacagt ttcaatctca tcttcccagc cttctttttt atcatagacc 1533481 ttcattttat ctatttgctc gggataatct ttttctaaat caagcagtgc atcgtaataa 1533541 ggcgcttcct ggtctatttg gttctcatca gaaaaaaaca ggatttgtgt atgatgaatg 1533601 ttgtcaatcc ggcttttttt catcggattg atggtggaaa gcgtacagcc cgataaagca 1533661 aatactatta tcagcatggg gaataccgcg cgatatcgca tctatcttct cctctgtata 1533721 aacagtagtt aactagcttt agtttatcac gagagacggc ttaatctgct tcttgttacc 1533781 taattgttat ataattgaaa ccgtttttaa agtgagatta catattatat caatcgttta 1533841 aaatagcaac ctggggtata ttgaattttt tgctgcattc ttggatgaaa gttcaagaaa 1533901 acgtgcaatt acattatgtg ctgtggcata tatatcgagt aaagcttctg tatgaagaag 1533961 atattgtatg atggaaaatg gaaaaacaag gtgaatatga tgatatgaaa taaaatgtgt 1534021 tatacagttt gttgttgaca ttttaaatgt gacatattaa tataataaca acaaaagaaa 1534081 ttaagcgttt tcaaatttca aagaaatggg gaataagaga tgggtacgat tgtttgccaa 1534141 gattgcaacg aagccattca ttactttgaa gatgagaaag tgacaacatt atatggaact 1534201 tgctgcggac aatgtcaatg tcctgttgat gaagagtaaa aaaaagcatg cggcttaaag 1534261 ccgcatgctt tttatttttt attgaattgc tttttgttct ttgatgaccc ggatcatatg 1534321 taaagtcgag tcctcaggtc cttgaacagg gaggcctgcg tcaaggtttt taaaaatgta 1534381 gctgatgttt tcttctgtaa taatttctcc tgggatgaag attggaatac caggcggata 1534441 taccatgaca aattcagcaa taatccgtcc ggatgcttct tttaatggga tgacttccgt 1534501 atttgcatag aaagcatcac gcggagtcat tgccaataaa ggtatttctg gaagcagaac 1534561 ctcagtttgc tgatgtgtta catcttgttc tgacatttgc tgtgcgatct cagttaaagc 1534621 ctctacaagc cggtctgcat cattttggct gtcaccagga gtgaaaatac acaaaatatt 1534681 gtacagatca gaaagctcca cctcaatatt aaaggattca cgaagccatt tttccacgtc 1534741 atgtcctgtc aggccaagac ttttcacaga gataatcaat tttgtcggat catagctgta 1534801 agctgctttc gacccaagaa tctcagaacc gacacaataa atgccttcaa tctgattgag 1534861 gcgatctctc gtctgattgg caagcttgag tgtttcctca gcaagctggc ggccttctgt 1534921 tgcaaggcgt tttctggcaa catccaaaga agcgagaagc aagtaagaag ttgacgtagt 1534981 tgtcagcatg ctcaggatgg attgcactct gtctttagat acaaggcctt ctctcatgtt 1535041 taaaatagag ctttgtgtca gtgatccgcc cagcttgtgt acacttgtcg ctgctatgtc 1535101 cgctcctgcc tgcatagccg atagcggcaa ttcgtcgtga aaatgaatgt gaacgccgtg 1535161 tgcttcatcc acaagcactg gcacatcaaa cgaatgagcg agttctacga tgctttttaa 1535221 gtcggctgca acaccgaaat atgtcgggtt gatgacgaga agcccttttg catccggatg 1535281 ctcggtaagc gcccgtttag cagattcaag tgtaattccg tgggagatgc ccaattcatt 1535341 gtcaatttca ggatgaataa aaattggaac cgctccggaa aatacaatag ctgtcataat 1535401 tgatttatga acatttcttg gaataataat tttatcacca ggtccgcaaa cagccattac 1535461 cattgtcata atggcgccgc ttgttccttg aacagaaaaa aatgtatgat ccgctccaaa 1535521 tgcttcagca gccagatctt gtgcttgttt aataatgcct tttggcgcgt gcagatcgtc 1535581 taatggttca atattaatca aatctatgct taacgcgttt tcaccgataa attgtctgaa 1535641 ttctgggtcc attcctgccc cttttttatg gccgggaatg tggaattgaa caggctgtct 1535701 gcttgcatgc tttttcagtc ctgtgtataa gggtgtttca tgttgcgaca attgttttcc 1535761 cacctttgta atcataccta tgcataatag tgtgtattaa aatcagtttc tcaaccgttt 1535821 tttagacgta aaacaaatga attatattat gaacttgaaa gaatgtaaag aacaatttat 1535881 gatcaaatga agatgctttc tcttaaggga agtaaatcta caaggagtga agaaaatgga 1535941 gtatcaatat ccgatgaatg aagattggac aaccgaagaa gcagtggatg tgattgcatt 1536001 tttccagcag gttgagcttg catatgaaaa aggggcggat cgtgaagaac tgcttaaagc 1536061 ttaccgccgt ttcaaggaaa ttgtaccggg gaaggccgaa gaaaaaaagc tatgcggcga 1536121 gtttgaggaa caaagtacat attctcctta tcgcacggtc aaacaggcga gagaatctga 1536181 tcacgcgaag attaagatgt aagaaaaaga gccgggggat atcccggctc ttttttatgc 1536241 ttgtgttact ttttgggtga gacggtacag aaaagcaagc tgtttaaagg catcgtcgat 1536301 acgctgaagg aattcctggt tattcatatt cagcacttct tctttttgga gctggatgcc 1536361 gcataacagc tcggctttct ttacagtctg caaacgctca aacagtgtct tcagctgttc 1536421 cttgtccatt tcagactgtt tatgtactcc cggttttgtg tgatctgcag accaaacgaa 1536481 gctgtcaggg atatttttcg taatggtttc ttggttcact tcaagcaatt tgccgtattc 1536541 ttctttgata ggggattcat aaataatcgc gaaccataca aagacgtggc tttcccataa 1536601 accaatttgg aaatgcggca gttttttata gcctcttttg ctgtttgcga acgccaccca 1536661 gctgtcagcc gggggattga cggatcttct tgcgtgcttt gccacatgcg gaaacatttc 1536721 atctccggtt aaagctgata aagttggggc aaaatgttcg cctagagctg taagcttcgg 1536781 acggaccgtc tcttttaata cttccatgcg cgcgtctaag ccttctattg taaatgtgtt 1536841 aaagtcttct tcagtgaaac gcatttgtgt catgattttc ctccttcatg ctaagtatac 1536901 atattttatc acagttcata cgagcttcaa aaagattgag cgcgtttgaa gtaaggagaa 1536961 atgtggtaat aaacgagtag gtaaacacac aattttcaga atcatgttgc gcgtaaatag 1537021 aacaatcata cgatataaga agtaatcatt gttgaatggc aaaatgggat gcttttttac 1537081 aaacaaatga tctctggaag gggcgaaaga caatgaggca agttgtaaaa gagggattta 1537141 aggaagagaa aaacaatcgt gttgctgtct ggagactaga ggttgattat gaattggcaa 1537201 ccctatatga agcaatgcag aaagaaaatg aagagcagat tgaacaaagc aaaaacaaac 1537261 ttgagcgact tagaaaagaa tggattcgtc ttaacgggta aaaaagcgat agtgaaaacg 1537321 aaccgcatga atggttcgtt tttacgtgag aagggatatt tttcattttc cttgcttttt 1537381 cattgccgtt atcagtatcc tataaaataa aaggtctaca tagaagagag gtacgaacga 1537441 atgacaaatt ggacggaaat cgatgagatt gcaaagaaat ggataagaga agcaggcgcg 1537501 agaattacac aatccatgca tgaaagcctg acaattgaaa cgaaatcaaa tccgaatgat 1537561 ttagtcacca atattgacaa agaaaccgaa aagtttttca ttgatcgaat tcaagaaaca 1537621 tttccgggac atcggatact cggtgaagag gggcaaggag acaaaatcca ctcacttgag 1537681 ggagtcgtat ggattattga tccgattgat gggacgatga attttgtgca ccagcaaaga 1537741 aattttgcga tttccattgg gatttttgaa aacggtgaag gtaaaatcgg tttaatttat 1537801 gatgtggtgc acgatgagtt gtatcacgca tttagcggca gaggagctta tatgaatgaa 1537861 acgaagctgg ctccattaaa agaaaccgtc attgaagaag cgattcttgc cattaatgca 1537921 acatgggtaa cggaaaacag aagaattgat caaagtgtgt tagcgccact tgtgaaaaga 1537981 gtcagaggca cacgctccta cggttctgcc gctttagagc tggcaaatgt cgcggcagga 1538041 agaatagatg cttacatcac gatgcggctt gcgccatggg actacgcagc cggctgtgtg 1538101 ctgttaaatg aagtaggagg cacctatacg accattgaag gagagccgtt taccttttta 1538161 gaaaaccaca gtgtgctagc cggaaaccca tctatacata aaacgatatt tgaagagtat 1538221 cttcatgctc ggaagtaggc catttgagca ggatgatctc agcttgttag aaaagctcgc 1538281 ggaggctcat cctgtatgga aagaggagga gtttggagat aaagatgcag aagactatat 1538341 catttcctac tccatgtaca acggttcatg gcttgtatgg gaaaaagacg gtatgcctgt 1538401 tgccgtcagc taccatctcg agtggtctcc ttcaaacggt aagccgtggc tcggaacggt 1538461 cctgattgac ccggctgaag aaaaaaaggg acatgcgaag atgatcattg aacagatcag 1538521 caaattgctt agagcgaaac ataaagcgat gtttgcggga gttcccattg agcgcaggga 1538581 atggatactg tttttaagcc aatgcggctt tgaacagctg aaaacggaaa aagatgagaa 1538641 aggcaaatca tttatgatct tggtgaagcc tttagcagaa gctgccgtat gataatggca 1538701 gcttatttgc tgcatgcggg ttcaataaaa agcctctcaa acattgagag gcttctgatg 1538761 atttgaaaat tattttttta ccgcatgaat ataatgaatc gtttcaaacg ctgacaaatt 1538821 gtcttttcga ttactaaaga aaaggtcatt gatgtcgtct ggtgatagat gttcatagat 1538881 cagtaaacca gatgactcta acagatgttc aatctcttga taagtgaaac atgatttcat 1538941 cggttccccg cttgcggcag ccatcttcac catatgttca actcgattcg acgtcccttt 1539001 tgctgtaaaa agtgtttcgt ccgcataatc aaaaacaata gagcttccag gcgggacatg 1539061 agaaaataaa ttgctgatca agcttgcatt ttcttcccgt gttacataat aagacactcc 1539121 gagaaggctg aagaatgttt ttgtgttttt aaatccttca tctaagagag gatcatacga 1539181 aaacgttttg gtgaaatcca taggaacaaa atgaagatga cccggaattg tcagatttgc 1539241 atccttcagc ttattttttt tcaattgctg tgtggccgga tgatcaacct cgaaaacctg 1539301 taagctgttt tctaattctg gatgccgaaa gcagaaagta tccagtcccg ctccaagaat 1539361 gacatactgt tttgccccca ggattaattc gttgtgcaag actttttcac aataagaagc 1539421 acgtgctagg ggcgttggag acagctggat ttgtgcaacc cattttaata ttttttcagg 1539481 atcattttga agacgttcgg cgatctcttt gttgaaaaac gatatttctt gaatcatatt 1539541 tttactgatg tcgataaact ctttttcgtt aatgagatct tttgcgataa aatcatcaaa 1539601 aataagaggt gtgtcatatc ggctgtgata tgcacgggca aaagctgaaa ttagagacgt 1539661 taagctggac tcatttttcc tcatgaaatg atcctccaca aaaaataaga ttcccctggc 1539721 caggagaatc ttattataca tacaaatata ttaatagtaa attttagcat aaataaattt 1539781 ttttgtcaat gtttttgctc ttaactggac gcgcgatcct tcacatagcc acgtgacctg 1539841 tagcagaatt cgtctatcaa ttatgtggac tgaatcatta gcttttataa aatgcgcact 1539901 tgcggctgca tccctcttta tgcaaatcag gagcggtttt ctgtctcatg gcagcatctt 1539961 ttcgtcgttt cagctgagag agaaatcaag atatgtaaca ataaaagcct gagggatctc 1540021 aggcttttcc taatattaca atccaacagc attccaggct gcttcaactt tagcggcatc 1540081 agttgagccg tagaggtcac gggcagactg aatgagagct gccttggcat ctttgaacgt 1540141 ggaagaaggc gtgaggtacg ttgttaacgc acggtaatag atttgctgtg atttagatac 1540201 accaagtttt gtgatggtgt tgtaagcggc tttgtttgga attccgctgt ttgtgtgtac 1540261 accgccataa tcgccttcat ctgtgtttgg aaggtttcgg taattggcgt aattgtcagg 1540321 ctggttgtat tttgtagggt tggacaggct gcgaagagca ggctggctga ccgtaatgtc 1540381 ttcaccgatg tcccagtctt ctgtatcgtt aaaatacccg aatacgtcag agaaagactc 1540441 gtttaatgca cctggctgat tttcataaat caagttggct gtttcttggg tgacgccatg 1540501 tgtcatttca tgcgctgtca catctaatga gccggaaagc ggagagaaga atgaaccgtc 1540561 gccatcaccg taaatcatct ggtctcctgt ccatgcagcg ttattgtatt gagtgccgta 1540621 gtgaacggaa gaaacgattt tactgccttt gttatcatag ctgtttcgtt taaagtttga 1540681 ataaaaataa tcgtacactt taccgaggtt atagtgtgcg tcaacggctg cccgctgtga 1540741 tgaagatgta aatgttttcg ttgtgcttga gacaagcgtg cccggaaggc ggctttgtct 1540801 gttttgcaaa tcatatgtga tgatttgggt gcctgttggt tttgaaagat ctcttagaac 1540861 atattttccg ccttcataag agatgttcaa aggaacagtt gcgcccttta gcgttgttcc 1540921 gcttccagtg gcggcggcat gttctacttt attttgctgt tttaaaatgc tgcctgtttc 1540981 ggcgtcaact aagacttccc agtttgcagg ttcaggctcg acatagcgaa tcgtcacgtc 1541041 gtaagcaaga cgatagctgc cgtcttttgt ttctatcgct tttaattcgg ctttattgct 1541101 gtttttggcc gctccgttag aaacagcgtc tggtgatttg ccgatagctt tgaaagcgag 1541161 tgccagcgct ttttcagaag agactttttg gctgttatct gtttttgcag cagattgatt 1541221 gtgtaattca ccattgaccg catagacatt atcggattta tcgacgtgaa cgatcacttg 1541281 cgaatcttta attggcactc cgttaacgac aggcgcatat cgaaagtgct tgtatccaag 1541341 ggcatcagtc gtgctttcaa caagcttcag ccttttggaa gggtcacctt taaaaatgtt 1541401 gctgttcttt ttcaaaaact gcttgacagc cttgtcattt ggtgcagaga gttctgattg 1541461 cgcaatcgcg tttttggaga ggaaatttgt ttgattctct ttaagctgat gaccttcagc 1541521 agcctgaaca cctggcaggc tgattgataa actcataaac gaagcagcga cagcaacaga 1541581 caatttctta cctaaaccca caataaatcc ccctttttga aaatactgaa aactttatat 1541641 tgttatatta aactagcatt ctggaatact caacaaaaac taacataact agacaaaatt 1541701 gatagtattg tcctgtgttt gtttttgttg aataatatca agatgagtca agtgtcatgt 1541761 ggtggttcat tcaagagtta tgttttttac atatcaaggg gaagatgaga tatttttgtt 1541821 tcatcttgaa actttttgaa aagtccgctg tctaaccgaa tgaggcctta ataagaagta 1541881 aaggattgtt gttcgtgttg gagttattca gtcattatgt attgcatttc gaacgttatt 1541941 ttatattaag cagacaaagc accctgctga ttcaatggtc aattgttgtt ctggcgggct 1542001 tatatctttt ggtgcatcat cccaaaataa accggcagcg cacaatgttc ttggcgggtg 1542061 ttatattgcg gattgtgctg ctggcgggag tgtctgttga acttattcac caggtgcaat 1542121 caacaaactt caccagcgct tacttaagag aggacggaaa agaactgctg ccgctgctgc 1542181 attttttgtt atacggatat gtgctgctga cggcttttca ctatatgctg atgccgcgtg 1542241 atcatggcgg aaagggtaag ttttatacgt tcgaccttgc tgttgtcagt ttgccgatcg 1542301 tacaaatgat ttttagtttc ttttcgtatt ggaaggaata cccggatggg atggagccga 1542361 ttgcattcgt gtttctgttt ttcatcatca ctcttcccat tgcgttgaat gtagtgtttt 1542421 tcaagctgta ttggagaacg gataagatct tactaggctt attttatacg ctgattatcg 1542481 gactgcttgt cttgctgctt gcgccatatc ccaatcaaat ctcaaaagat tatggtgcag 1542541 taatgccata tacgatttat ttggcaatgg cgggattttt gatgagctat catctgttcc 1542601 aaaagtcagg aaaggtttat gtgcgtgtga ataagtgggt gacgatggct gtcatggtgt 1542661 tttttgtcct gctgttaaat ccgatatata acataggaac ggctgctttc gctgtatcaa 1542721 agccagcaaa tgtccatgat tcattcaatt ttgtcgggga gcacatttca tcagaaaaag 1542781 cggaacagat actaaagtca ttttttccta cggatgaaac actttatttg cacgatacaa 1542841 acatggatgt gcattatttc tactcatttg aaagcaaagg ttacaaagct gaggtagatg 1542901 aagtatcgca gctaattcgt aattatgaat acttacaaaa agcacatggg aaaaagctaa 1542961 cgaatcagga gtacaagcga aagtccatcg ctttccttga gcgacacgga cgtgtgttac 1543021 ataaggatca tatcgaaaca aaggtatctc aagaagacgg ccagacagtc gtacgtattt 1543081 acctgaaaaa tcaacttcat aaaaaagatc atgctgatga tggcgcggta ttttattggg 1543141 aaaaggaaac cttaatgggg tttagtgaag atccttcgat ttatcagctt gactctcttc 1543201 tgcatgttca tataacggaa caagacattc acgacaaagt ggaacaaatg tttacagcgc 1543261 tgaacatatc aaaacagcct tatcagatca ctgatattga aagcgacagc ctgcttggaa 1543321 gcatggtgag agttgaaaca aaagttggaa ttgttttgga atttgagggc gaatcaggtt 1543381 gtttacatag tctttcgctt ccgatgaaaa agaatatctc aatggctaac agccggctgc 1543441 agcatcagat attatcgatc ttcgatgctc gtggatcaga aaagaagaaa aaaagcagtc 1543501 agggtgacat ggtgatgtat actgattctt ctaaaacata tgagtttgtt gaagctcaag 1543561 gtcagctaaa cgtttatgta tacagcgata cacctgatca gtcattcccc tatacgtatc 1543621 gtaatggaac attggcttac gaaaaagtag cttctctata tcaggatgtc atttacaaaa 1543681 agcgtatgcg tccgattatc gttcaaagag gggatgaacg gcattatgca tggctgatca 1543741 ttattcagcc gtttggttca aatcgccatg atgcctatgt agtggatgga gaaacacaag 1543801 aggtgaaaag tctttatgaa tcataaagaa aaagagtctg tttttgtaga cttatacgac 1543861 ctgtataaag aaggagagct agaggatgaa tcaatggaat ggatgaaaca gcatgaatcc 1543921 ctatttcaaa agaatgcgga agacttaaag agtaaaactt gtttaaagag aagtcccggt 1543981 gctgaagaag aaagccaaat cagatatatg aaagtatacc tgtcttccat gtatatctgt 1544041 ttcattttat tggccatttg gatgacggtg tggttttatt tttaatgaag catagggatt 1544101 ccattgagga cttgtatcgg cagtattatc aagaaatttt aaattattta ttcagaagga 1544161 ctcatcatct tgaaacagcc aaggacttag cgcaggacac gtttgtaaaa gctcttaacg 1544221 gtctggcttc gtttaggggg cattcttcca tcagaacatg gctctacacc attgcgcatc 1544281 atacctttat caattggtac cgaagggatg tcaaatacca atttactgaa atcagcaaaa 1544341 atgaagggtt aacgcaaaca acttatgacc agcctgaaca gtatctgtca cggacggtga 1544401 aaagcgaaac actgcggcag gagctcctga agttaaaaga tcagcatcaa tccgttttga 1544461 ttttaagaga attccaagag ctttcttatg aagaaatcgc tgagatatta ggatggagtc 1544521 tttctaaggt gaataccaca ttgcaccggg ctagattaga gctaaagaaa aacatgacga 1544581 aaagtagaga ggaggagcgg atatgacctg ctttctagta agagacctgc ttcctctgta 1544641 tcttgaaggt gattgtaaaa gagaaacgga acacgttata gaagagcatt taaaaatgtg 1544701 cagcagctgc agagacatgt atgacacgat ggctgagcca tttgaattgg aaagcgaaca 1544761 ggccgttgag gaggcttatc tgccggaaga agaactgcgt tttaaacaga ggtactatgg 1544821 attactgatc atgaaagctg cctgctggtt tggagcggcg gttgccatga tgctgatcat 1544881 caaactgctg atataaaaaa agcgcttgtc cgattccggc aagcgctttt ttacattaag 1544941 cctggggatg aatcatatcg taaatagcgg caagctgttc ttgtgacagg gcactgaaga 1545001 gtttttcata aacgtcagct tgcagtggcg ttgcacctgc ttgtagcgct gcgtctttat 1545061 catagctgta cacatcatct tgtagcacaa tggctgcttg aagaatgtga atcttgagag 1545121 aaacagcgga gaaaaattgt tcaagtgcaa gtgcttcttt ttctgtgaag ccaagttcaa 1545181 ctgctttttc tgtatcaaat ttgtaatttc catcctcgag atacacacat tgtgaaacaa 1545241 tgctgaaaaa ttctgatgtc gattcccaga gtgtagcaat tacctgagcc tcttcttttg 1545301 tcattcctaa ctcgacagct ttttcgctgt caaaataata tacaccgtct tgttcgtata 1545361 tacattgatt taatatatca atgaatgtat tgagatcttc gttagtgctc gcctgatgct 1545421 ggagttgaac agcagtgtta tcaaccggtg tttttgcgct ggctgcatca ggaccgaacg 1545481 ttaatagagc agctgaggtc attgcggcag tcgttaacat agcttttttt acaaatgttt 1545541 tcttcatgtt tcttctctcc cttttatgaa ttgtgctaca aattccatta tagggagtag 1545601 tttccggtgg aggaataggc gctatggtat tttatgtgta tcgttgccga actacttttt 1545661 gaaggctgca cgtgtgatcg ttagaacgat tgtctatgta tgaaggctgt tttgcatctt 1545721 cctgactaag aaacagggga gataaggctt aaagaaatga aaaacaccgc tttctttgcg 1545781 gtgttttttg attacaatgt cgccggcggg gcaatgcttt taatcaagca agccttgttc 1545841 gcgcattttc ttttttaatg taaatccgcc gcccatgaca gcgcaaacaa gtacaatgct 1545901 ggcgataatg cctgcagggc ttttttcagc gataaagacg ccgatcagca taatgctgaa 1545961 aaccgctgca aatgcaaata atagtaaaag ccaattcatt tttttcataa attccatccc 1546021 cttttacgtc ttatattaag tttacagaaa aacgtgacgc ttttaaagag gatgtgtgat 1546081 ataatatgaa agttatctaa tttttttagg agatgaaaaa gtgaaacttc gaaatgatct 1546141 tcgcaacatc gcgattattg cccacgttga ccatgggaaa acgactctag tcgatcagct 1546201 tttacatcag gctggtacgt tccgtgccaa cgaacaggtt gctgaacgcg caatggactc 1546261 taatgatctt gaacgcgaac gcggcattac aatattggcg aaaaatactg cgattaacta 1546321 taaagataca cgtatcaata ttttggacac ccctggacat gcagactttg ggggagaagt 1546381 agaacggatt atgaaaatgg ttgacggcgt agtgcttgtc gttgacgcat atgaaggctg 1546441 tatgcctcaa actcgttttg ttctgaaaaa agctcttgag caaaacctga accctgttgt 1546501 tgttgtaaac aaaattgacc gtgactttgc tcgtccagag gaagttatcg atgaagttct 1546561 ggatctgttc attgagcttg atgccaatga agagcagctc gagttcccag tggtatatgc 1546621 ttccgcgatt aatggaacag cgagtcttga tccgaaacaa caggatgaaa acatggaagc 1546681 tttatatgaa accattatta agcatgttcc ggcacctgtt gataatgcag aggagccgct 1546741 tcaattccaa gttgcccttc ttgactacaa cgactatgta ggccgtatcg gaatcggacg 1546801 cgtattccgc ggcacaatga aagtcggaca gcaggtttct cttatgaagc ttgacggaac 1546861 ggcaaagtca ttccgtgtta caaagatttt tggtttccaa ggcttaaagc gtgtggaaat 1546921 tgaagaagca aaagcgggag acctcgttgc ggtttccggg atggaagata tcaacgttgg 1546981 tgaaacggta tgtcctgtag accatcaaga tccgcttccg gtccttcgca ttgatgagcc 1547041 gacacttcaa atgacatttg tcgtgaataa cagtccgttt gcaggccgtg aaggcaaata 1547101 tgtaacggcc cgcaaaatcg aagagcgtct tcaatcacag cttcagacgg atgtgagctt 1547161 gcgtgttgag ccaacagctt ctcctgatgc ttgggttgtt tcaggacgcg gtgagctgca 1547221 cttgtcaatt ttaattgaaa atatgcgtcg tgagggctat gagcttcaag tgtcaaaacc 1547281 tgaagttatt atcaaagaaa tcgacggcgt acgctgtgag cctgttgaac gtgtgcaaat 1547341 tgatgttcct gaagagcata ctggctctgt aatggaatca atgggtgccc gcaaaggcga 1547401 aatggttgat atgatcaaca acggaaacgg ccaagtccgt ctcatcttta cagttccttc 1547461 ccgcggattg atcggttact ctacagaatt cctatcatta acacgcggat tcggtatttt 1547521 gaaccatacg tttgacagct accagccgat gcaggcaggc caagtcggcg gacgccgtca 1547581 aggtgtactt gtgtcaatgg aaaacggaaa agcaacatca tacggtattc aaggaattga 1547641 agaccgcggt gtcatcttcg ttgagccggg tactgaagta tacgaaggaa tgatcgttgg 1547701 agagcataac cgtgacaacg accttgttgt taacgtcagc aaaatgaaac agcaaacaaa 1547761 cgtccgttct gcgacaaagg atcagacaac tacaattaaa aaagcgcgca tcatgtctct 1547821 tgaggagtct ctagagtact taaacgaaga tgaatattgt gaagtaacac ctgaatccat 1547881 ccgtttaaga aagaagatcc tcaataagaa cgaacgtgaa aaagcagcta aaaagaaaaa 1547941 aacagcagga ttgtcttaat ctcgtgcaga atttgaaaag atagaacccg tacgtttaca 1548001 ggggagggaa tctttttgaa tgacgtaagc gaacgcctgt cgttcttcgc cgctctatat 1548061 caagtagacc ggcagcctgc ggcaggcatg tggctgctgt acggcacgat ttttgtgttg 1548121 gccgttattg tatttaagct tggatttgct aaacggcttc ctgtattaaa atctgcagtg 1548181 gtgtatgtat ttttggcttt gggctgcact gttttgactt ttttaggggt gtttttgccc 1548241 gtggcagaag gattggtcgt cgctgcgctg attttaatca tttacaaaat ccggctgtat 1548301 cagtcgaaaa aaggacagtc tgcaaaatca taaaagactc agctgaaagc tgagtctttt 1548361 ttgtgttctg tatggttaag cggccgcttt attttttgac tttttctttt ttctgctgtc 1548421 ccgggtgaaa agtaaatttt cccgttttca gccgttcctc tgtttttttg gcaatccgat 1548481 cgtggcattc ctggcacata tatgtatgga tcgggcggtt tcgaagccgt ttcgcgatca 1548541 gggtatcatc atcaattgtt tcaattttat cgcaaataga acatttgacc ctcatcatat 1548601 cacctctttc actaacatgt attataccac ggatcagaag ctgtccaaaa taagaaaaag 1548661 ctaaagcgca aggctatagc ttagtcattg ttgttctttt tcatatgatg atcagattga 1548721 tcgttttgtt ccttctccat ttcctgttgc tgttttctat ttaattggtc attttgctgc 1548781 tttgtttgcg gttcatcttc attgtcaatc acatcgttag gcacttcggg aagcactcgg 1548841 ccgacaattg cagctaattc atccagtata cctgttaccg gatggccctc gctgatttct 1548901 ctgctcattt cgcgaaggcg gctgaccgta tcgggatcag caatgactac tgcgttggcg 1548961 ccatatcgat cattctttag cgcctgagct acagaatatt taatggtttc cactttgctt 1549021 ctgtccaaag tatcatcgac atcaatccca acaacagcat agcctcccag cacaacggct 1549081 gttgcatcct tgacgtcggg gtttttttca gcaacgctga caagatgctt ggcaatatcc 1549141 gttcttgttc cattgtcttt tgtttcttga gttgtgtcct ttacgtgaat cggtttagtc 1549201 tcctgctgtc ttgttgattc tttttcaaca ttctggccct gttttccttg ttgataggca 1549261 caagcggaca ggataagtgt cagctgtatg ataatgaaaa gaattcgcac ttgcgggttc 1549321 cctccttaaa atgctttcat taattttatt gttgaattaa ccttctatct ttatgcacaa 1549381 aaacatatat tttagcaggc attcaccttt ttcatcaaaa gagaagcagg aagaactttg 1549441 acccttatat caggaggctg agacttgagt aaaatttatg tgttagatac gaatgtgtta 1549501 ttacaggatc ctaacgcgat attttctttt gaagaaaatg aggttgtcat ccctgctgtc 1549561 gttttagaag aggttgattc aaaaaaacgg tatatggacg aagttgggag gaatgcaagg 1549621 cacgtatcta agctaatcga tgcgctaaga caaaagggca ggctgcatga gcatgtaccg 1549681 cttgacaccg gcggcacact gagaattgaa ctgaatcatc gttcgtttca ccagctgcaa 1549741 gagatcttta ttgaaaagac gaacgataat cgcatattag ccgttgcgaa aaacttaagc 1549801 ctcgaggaag aaaccaagga aaatggcagg ccggttatcc ttgtcagtaa ggatgtactg 1549861 gtcagggtta aagccgacgc aatcggactg cttgctgaag atttcttgaa tgaccgggtt 1549921 gtggacaatg atgaaatgta cagcggctat aaagatttat atatcagcca gcagctgttc 1549981 agctcttttt acgggaaaaa tcaaatttca gtaaacgatg tgaaacagca tgcgttttat 1550041 ccgaatcagt ttgctttaat gaaggatgag ctaggagggt cctcctcggc agtcggaatt 1550101 gcagacaaaa ccggaacggt attaaaaaga ctcgtatttg atgatgaaca tatatgggga 1550161 atcaggccga aaaatgtaca gcagacaatg gcattagagc ttttgctgcg ggaagatatt 1550221 ccgcttgtca ccctgatcgg caaagcggga accggcaaaa cgctcttagc tttggcggca 1550281 gggctattac agacagaaga cttgggaata tataaaaagc tggtcgtcgc aaggccgatt 1550341 gttcctgttg gcaaggacat cgggtatttg ccaggcgaaa aagaggaaaa gctaaagcct 1550401 tggatgcagc cgatttttga caacttagag tttctgttta atgcgaaaaa accaggggag 1550461 cttgatgcta ttttggcggg aattggctca attcaggtag aggcgctgac ttatatcaga 1550521 gggagaagca ttccagatca atttattatc attgatgaag cgcaaaattt gaccaggcat 1550581 gaggtgaaaa cgttgctgac gagagtcggt gagggcagta aaattgtctt aatgggcgac 1550641 cctgaacaaa ttgatcaccc atatttagac agtctgaaca atggtttggc ctatgtggtt 1550701 gagcggttta aaggacaacc catctcaggc agcgtgaagc tgttaaaagg tgagagatca 1550761 ggtctcgccc agcttgcagc tgatttgctg taacacttaa atgatttcga tctcttttac 1550821 atcggtaatc ggctgtttgt gatgaaccgg gtcttcaaag taaatatgca cggggccgcc 1550881 ttcttgaatc ggcttgcctg cctcactgaa atggacaata ctgttcagag cggtttccag 1550941 agaaacggcg gcctttcccg aacttgtgac aaatacacat tgtgtcgcag agctgttcgg 1551001 ctcagcattt ttcaggacag tcccaagtct cattgcgaaa ctgccgttca tcagtttttg 1551061 cttctcatat tgcttttccg tctttaatgt aggcggcgcg attcgcccct ctctgatgac 1551121 gcgttccgga tcaaggtcgg attcatcccc ggctgattgt aaatatgtgt cttgactgtc 1551181 ccctttgcgg tcaaacgaaa atttgcgatc atcaaaaatc catacgcttg gatcaatggt 1551241 aattggatat gtaacattgc cttttacttg gataacgctc atgatatgac ccccttctct 1551301 caaaattata aaagttttcg catgaattgt cactttgtgt acaaattatg tgtattgaaa 1551361 tgctgaggga acgagggtgt ttgcatggta tgccagcata atgatgagct tgaagcctta 1551421 gtgaaaaagg cgaaaaaagt aacggacaag ggggaggtag ccagctatat tcccgccttg 1551481 gcaaaagctg ataaacacga cctgtcagtg gcgatttatt attccaataa tgtttgtctg 1551541 tcagcaggtg acgtagaaaa aacatttacg cttcaaagta tatcgaaagt cctttccctt 1551601 gctttggtgt taatggaata cggcaaagat aaggtcttca gttatgttgg acaggagccg 1551661 accggtgatc cgtttaattc aattatcaag ctcgaaacag tgaatccgag caagccgtta 1551721 aaccctatga ttaatgccgg ggcattggta gtgacaagtc tgataagggg aagaacggta 1551781 aaagagagac ttgattattt gctttctttt atcagaaggc tgacaaacaa ccaagagatt 1551841 acatactgcc gggaagtggc tgaatctgaa tacagcactt caatgattaa tcgggcgatg 1551901 tgttattata tgaagcagta cggcattttt gaagatgatg tagaggcagt aatggattta 1551961 tatacgaagc aatgcgcgat tgagatgaac agcttggatt tagcgaaaat cggatctgta 1552021 ttcgcattga acggcagaca tccagagact ggggagcagg tcatctcaaa agatgtcgct 1552081 agaatttgca aaacgtttat ggtgacgtgc ggaatgtaca atgcaagcgg ggaattcgca 1552141 attaaggtcg gaattcctgc gaaaagcggc gtatccggcg ggataatggg catttcgcct 1552201 tacgatttcg ggatcggcat attcggcccc gcattagacg aaaaagggaa cagcattgca 1552261 ggtgtaaagc ttttggaaat aatgtctgag atgtacaggc tgagtatttt ttaatttatg 1552321 tcatatgctt aaatcctctt gcattttctg ttgataccct ttatgataaa tagaagaatt 1552381 aggtactcgc ctggggaacg gagggatact tttggcttca gagatgatag ttgaccatcg 1552441 gcaaaaagct tttgaactct taaaagtgga cgctgagaag attttgaagc tgatccgagt 1552501 acaaatggat aacttaacga tgcctcaatg tcctctatat gaagaggttt tagatactca 1552561 aatgttcggg ctttcgaggg aaatcgattt tgctgtccgc ctgggattgg ttgatgaaaa 1552621 agacggtaaa gaccttttat acacattgga gcgcgaattg tctgctttgc atgacgcgtt 1552681 tacagctaaa taaatgataa aactcaaact tattaacagt ttgggttttt ttataaccgc 1552741 tatttttctc tcatctcata aaagacggtc tttttttaca cattccttcc gaatcgtata 1552801 gagattcttc gtctcgtttg ataaattgta gtaaaataaa aaagataaat acataaaaac 1552861 catagataat ggaagttaga agcagggaag aggatgttat gttaaaaaaa atgctaaaat 1552921 cttatgatta ctcactgata ttcgcaatcg ttttattatg cggattcggt ttagtgatgg 1552981 tatacagctc aagcatgatt acggctgtct cccggtatgg agtaagcagt aattttttct 1553041 tcatgcggca gctgtttgct ttaattgcgg gtggcgctct atttattctc atggcgttgt 1553101 ttccttataa agcactggcc catcaaaagt ttcagaaggg gatactgctt gtatctgttc 1553161 ttgcgcttat ctcactgttt gttttcgggc atgttgccgg aaacgcgcag agctggttta 1553221 aaatcggcgg aatgagtatt cagccggggg agtttgtgaa actggtcgtg attttatacc 1553281 ttgcagccgt atatgcaaaa aaacaaagtt atatcgacca tctgttaacg ggagtagccc 1553341 ctccggtagt catgacgctt ataatttgtg ggttaattgc catgcagcca gatttcggta 1553401 cagccatgat tatagggtta attgcgacgt gcatgatctt gtgctccggc ttcagcggaa 1553461 agacgctggt gaggcttgtg atactgggcg gaattgtttt cattttagtc agccctatta 1553521 tctatttgaa tcaggacaaa attttaactg aaggccgttt agcgcgtttt gagagtcttg 1553581 aagacccatt taagtatgca aattcatcag gtttgcaagt gatcaattct tattatgcga 1553641 tcagctcagg cggcattttc ggcctggggc tcggtgaaag tatccaaaaa tacggatatc 1553701 tgcctgaatc acacactgac tttattatgg ctgtcattgc tgaagagctc ggcatttttg 1553761 gggtattgtt tgtgattttc ttattgggtt ttgtcgtcat aaaaggtttt tatattgcca 1553821 gaaaatgcga ggacccgttt ggaagtcttc tggcgatcgg catttcaagc atgattgcca 1553881 tccagtcgtt tattaacctt ggcggtgtca gcggattaat tccgattaca ggggttacgc 1553941 tgccatttat cagttacggg ggctcttctt tggtgctgct gctggggagt atggggatat 1554001 tagcgaatat cagcatgttt gtgaaatatt cagagaataa gaaaaagaaa gagcccttgg 1554061 cgccgaaggg aatgaaaaag aaacagctca aaaaaactgt ttatctgtaa aaaacaagtg 1554121 tgtacagggg aaggatattc cgctatgata gattatattc cattcgggta agggggagaa 1554181 aagtttgtct cagcaatcga tacaaaaagt attagtagca aacaggggag aaattgcaat 1554241 ccgaatattc cgggcgtgta ccgagttgaa tattcgtaca gttgcggtct attcaaaaga 1554301 agattccggt tcctaccatc ggtacaaagc ggatgaagca tacttggtcg gtgaagggaa 1554361 aaaaccgatt gatgcttacc tggatattga aggtatcatt gatattgcga aaagaaacaa 1554421 agtcgatgca attcatccgg gatacggttt cttatctgaa aatattcatt ttgcgagacg 1554481 atgtgaagaa gaaggcatcg tattcatagg gccaaaatcc gagcatctcg atatgtttgg 1554541 tgacaaggta aaagcgcgtg agcaggcaga aaaagcggga atccccgtga ttccgggaag 1554601 cgacggtcct gccgaaacgc ttgaagccgt cgaacaattt ggacaagcta acggttatcc 1554661 gatcatcatt aaagcctcgc ttggcggcgg cggccgcggt atgcggattg tcagatctga 1554721 aagtgaagtt aaagaagcat atgagcgtgc taaatcagag gcgaaagcag cctttggcaa 1554781 tgatgaagtt tatgtagaaa aattaattga gaatccgaaa catattgagg ttcaggtcat 1554841 tggagacaag cagggcaatg tcgtccatct ttttgagagg gattgctccg ttcaaagacg 1554901 ccatcaaaaa gtcattgaag tggcgccgag tgtctcgctg tcacctgaat taagggacca 1554961 aatttgtgag gctgcagttg cgcttgccaa aaatgtaaac tatataaatg cggggacggt 1555021 cgaattcctt gttgcaaaca acgagttcta ctttattgaa gtaaatcctc gcgtacaagt 1555081 tgaacacacg ataacagaaa tgattactgg tgtcgatatt gttcaaactc agatccttgt 1555141 tgcccaaggg cacagccttc acagcaaaaa agtaaatatt cctgagcaaa aggacatttt 1555201 tacaatcggc tatgccattc agtcacgggt tacgactgag gatccgcaaa atgatttcat 1555261 gcctgataca ggaaaaatca tggcttaccg ctcaggcggc ggttttggtg tccgtcttga 1555321 taccggaaac agcttccagg gcgccgtgat cacaccatac tatgattcac ttctcgttaa 1555381 gctttcaact tgggctttaa cgtttgaaca ggcagctgcc aaaatggtgc gaaaccttca 1555441 ggagtttaga atcagaggca taaaaacgaa cattccgttc cttgagaacg ttgcaaagca 1555501 tgagaagttc ctgacagggc aatatgatac atctttcatt gatacaacgc ctgaattatt 1555561 taatttccct aaacaaaaag accgcggaac gaaaatgctc acttacatcg gcaatgtgac 1555621 agtgaacggc ttccctggaa tcgggaaaaa agaaaaaccg gcgtttgaca aaccgttagg 1555681 cgtaaaggta gacgttgatc agcagcctgc cagaggaaca aagcaaattc tcgatgaaaa 1555741 aggtgcagaa gggcttgcaa attgggttaa ggagcagaaa tctgtccttt taactgatac 1555801 gacattcagg gatgcccacc aatcgttatt ggcaactaga atcagatcgc atgatttgaa 1555861 aaaaatcgca aatccgacgg ctgcgttatg gcctgaacta ttcagtatgg aaatgtgggg 1555921 aggcgcgacc ttcgatgtag cctaccgatt cctgaaagaa gatccgtgga aacgtttgga 1555981 agatcttcgc aaagaagtgc cgaatacctt attccagatg ttgcttcgct catcaaatgc 1556041 ggtcggctat acgaattatc cggacaatgt gattaaagaa tttgtgaagc aatcagctca 1556101 atccggtatt gatgtgtttc gtattttcga cagcttaaac tgggtaaaag ggatgacgtt 1556161 agccattgat gctgttaggg ataccggcaa agtggcagaa gctgcgattt gttatacggg 1556221 agatatcctt gacaagaacc ggacgaagta cgaccttgca tattatacat cgatggcgaa 1556281 ggagcttgag gcggccggag cccatattct cgggattaaa gatatggcag ggctgttaaa 1556341 accgcaggct gcatatgagc tcgtttctgc gttgaaagaa acgatcgaca ttccggttca 1556401 ccttcatacg catgatacga gcggaaacgg tatttatatg tatgcgaaag ctgttgaagc 1556461 cggcgttgat atcatagacg tggcggtcag ctcaatggcg ggattaacgt cacagcctag 1556521 cgcgagcgga ttttatcatg cgatggaagg caacgaccgc cgtccggaaa tgaatgtcca 1556581 aggcgttgaa ttgctgtccc aatattggga gtcggtgcgt aaatattata gtgaatttga 1556641 aagcggaatg aagtctccgc atactgaaat ttatgaacac gaaatgccag ggggccaata 1556701 cagcaacctg cagcagcaag ccaagggagt aggccttggc gaccgctgga acgaagtcaa 1556761 ggaaatgtac agacgcgtga acgatatgtt cggtgacatc gtcaaggtaa cgccttcctc 1556821 aaaagtagtc ggagatatgg cactctacat ggtgcaaaac aatctgactg aaaaagacgt 1556881 ttacgaaaaa ggtgaatctt tagatttccc tgattctgtc gtggagcttt ttaaaggaaa 1556941 tatcggccag cctcatggcg gattcccaga aaaactgcaa aagctgatct taaaagggca 1557001 ggagccgatt acagtcagac cgggcgaact gcttgagccg gtgtcatttg aagcgatcaa 1557061 acaggaattt aaagagcagc ataacttgga aatttcagat caggatgctg tggcatatgc 1557121 cctttatcct aaagtcttca ctgattatgt gaaaacgaca gaaagctatg gagacatctc 1557181 ggtattagat acaccgacat tcttctacgg tatgacatta ggtgaagaga tagaagttga 1557241 aattgagcgc ggcaaaacgc tgatcgttaa gctgatttca atcggtgagc ctcagcctga 1557301 tgccacccgc gtcgtttatt tcgaactcaa cgggcagccg cgtgaagtag tcattaaaga 1557361 tgaaagcatt aagtcttccg ttcaggaaag gctgaaagca gaccggacaa atccaagcca 1557421 catcgcagct tccatgcctg gaacagttat taaggtattg gctgaagcag gcacaaaagt 1557481 caataaaggt gatcatttga tgattaatga agcgatgaaa atggaaacaa cggttcaggc 1557541 gcctttctca ggaacaatca agcaggttca tgtgaaaaat ggtgagccga tccaaacggg 1557601 agatctgctc cttgaaattg aaaaagcata aaaaacaaag agtgtatatc aatgatatac 1557661 actcttgttt tttatataga aaatgtggag tgaaacagat ggttagaaga gatataaggg 1557721 gacttcagag attatagagt actgtcacaa gcccaaaata aaaagaggct tatacagcca 1557781 atattttaga tgctttgtag tatgccgtgc atatttcttt aagcactatc tgatttaaaa 1557841 ggctttaata cttatgttcg cgagctatag atccatatga aatttctata atcacgatga 1557901 gaaaggggac agaccgaagt gagccgctca ctgatcatca agttcggcga aggctggcga 1557961 ttgaaacgca taaagcgcca aaaaacaaga cataaaaaag accaaagccg cctaaggctt 1558021 tggtcttgag tccttatgat tgcctggatt cataacggaa acgagcaatc aataataaga 1558081 agtagcatag aacgccaaac agacaggcaa taaagaacga gtgggcaagt gcaaagccca 1558141 gagccagttc agagtatacg atcataatac cggacagtgc ctgtaatgta atgaaaataa 1558201 gacatgagat ccatccccaa aagatctgtt tttgatcttt ataggaagta atagcatgaa 1558261 cagcggcaac aataatccat acaaataaaa gtaaggctgc tgctctgtgg cccatttgca 1558321 cccattcatg gaattgggtc ggaagtccat tgttcagcgg gctgcacagc ggcacattag 1558381 gacatgccag acttgattca gtgtgtctta catatgcgcc tgtatacaca acgatatagg 1558441 aatatattaa aattcctatc atgtgaaatt gcatcttttt gccgatttga agcggcttaa 1558501 ccagtgttct gactgattta tcagcttcaa atatgagcaa tgttaaaata agcactgaag 1558561 caaaagaaat taatgagatg ccgaagtgaa gcgccataat cagcgcgttc gaaccgaata 1558621 cgacagccaa tgcgccaagc aatgcctgaa gaaataaaaa gataattgac atgatcgcga 1558681 gaaacgttgt ttcacgaaaa atcggcgtga tttttctcca tgaccaaaac gcaaggctta 1558741 gcacaaggat aatagagatt ccgcttgcga atcggtggct ccattcaata attgaagccg 1558801 gattcagttc agggaaaaaa cggccgtgac acagcggcca ctgtctgccg catccttggc 1558861 cggaacctgt ttttgtaacg agggcacccc cgattaaaac aattagcatg acaaatgtcg 1558921 tcagaacacc gagagctttt aatgctttat tcatacaata ttcaccttct taacatactg 1558981 ctgcaatttt atatacgttc caagtgtaag cgaatatgtg ttttgtggca attcccagag 1559041 ccttttgttc acaaaaatat aatagaatga cggcttctgg aaaatgtaca cttgattatt 1559101 catgccgggt ctgatagaaa taaggtaaac gcaatgccga tttggagatt gccttcatct 1559161 ttggtaaaat tcataaaaag ttcacaaata aattcctgtt tgtcgtttaa tatttaatag 1559221 gatgtttttt tacaagatgt tatcttgtat gatagagttg caggttattt tattctcctg 1559281 cgttaggttt gtaagggagg tttacgttat ggctaactcc agaatcttaa atgatacagc 1559341 tatagacgga caaattgaag aaacaacggc atggaaagat tttctgtccc ttattaaaat 1559401 agggatcgtc aattctaacc tcatcacgac tttcactgga atgtggcttg cactgcatat 1559461 atccggttta agttttttag gcaatataaa caccgttctt cttacgttaa tcgggtcttc 1559521 actgattatt gcgggctcct gcgcgatcaa taactggtat gaccgggaca ttgaccatct 1559581 tatggagcgt acgaaagtaa gaccgacggt tacgggtaaa attcagccga gtcaggcgtt 1559641 atggtctgga attttgctgg ttgctttagg attgatcatg ctgctgatga caactgtcat 1559701 ggctgctgtt atcggtttta tcggagtctt tacgtatgtt gtattgtaca caatgtggac 1559761 gaaacgccgc tatacgatta acacagtagt aggaagcgtt tccggtgcag tgccgccgct 1559821 tattggatgg acggcagtgg aagggaatat cggtgtcgta gcatgggtgt tattcatgat 1559881 tttatttatt tggcagattc ctcacttctt agcattggct attaagaaaa ctgaggatta 1559941 cagagctgca aatattccga tgcttcctgt cgtatacgga tttgaagtga caaaaagaca 1560001 aattattgtg tgggttgcgt gcctgatgcc gcttccgttt ttccttggta gcctgggtct 1560061 tccgattgtc attctcggct tgctgttaaa tatcggctgg ctgattcttg gcttaatggg 1560121 attccgctcc aagaatatca tgaagtgggc aacgcagatg ttcgtttact cgcttaacta 1560181 catgacaatc tatttcgttg ccatggttgt cttgacgctt ttctaaaaaa tagatatgat 1560241 gcttgtttta tcgcttcaaa ataaacgatg acaactagta aatgccgcct tgacctcttg 1560301 tttaatcagg cggctttact tttatacata gatggcattt tgagtaaaaa aactcataat 1560361 ttaagagaag aggaaatgta agtgctttat tggtgatagg ttggatggcg atagatttcg 1560421 atccgctttc cgcctttgta ttgaccagaa aaggggttgg gtgaaatggt aaagcattgg 1560481 cgtcttattt tattattagc cttagtgccg cttctattaa gcggatgtgg aaaacctttt 1560541 ttatccacgc tcaagcctgc tggcgaggtg gctgataaac agtatgacct gacagtgctc 1560601 agcacattga ttatggtggt tgttgttgca gtagtatctg ttatcttctt ttatgtgatt 1560661 gtgagattca gaagatcacg ggtcggtgag aacacgatac cgaaacaggt agaggggaat 1560721 aaatttttag aaatcacatg gaccgtgatc ccgattttgc tgctcattat tcttgtgatt 1560781 cctgttgtat tatatacgct ggagctagcg gacacatcac caatggataa aaaaggccgc 1560841 aaagctgagg atgctcttgt agtcaatgtt agggcaaatt tatactggtg ggagtttgag 1560901 taccctgatt acggcattat cacaagccag gagctgattg taccgacaga tcagcgtgta 1560961 tattttaatt taaaagcctc tgatgtaaaa cattccttct ggattccttc agttggagga 1561021 aaacttgata cgaatacgga taatgaaaat aagttcttcc tgacatttga ttcaaaacga 1561081 agcaaagagg caggagatat gttttttggg aagtgtgcag agctttgcgg cccttcacat 1561141 gcgctgatgg attttaaggt gaagacgatg tctgcaaaag aatttcaggg ctggacaaaa 1561201 gaaatgaaga actataagtc tacagcagag agcgatttgg ctaagcaggg tgaagaactg 1561261 tttaaagaga aaaactgcct gagctgccat gcggtagagc cgaatgataa gcgtgcagaa 1561321 gccgctagaa cggcacctaa cttggcgacc ttcggtgaaa ggacaaaagt ggcaggggtg 1561381 aaagaggcca acaaagaaaa tgtgaaggct tggctgaagg accctgacag cataaagccg 1561441 gggaacaaaa tgacaggcac atatccaaag ctctcagaca gcgaaacaaa tgcgctttat 1561501 gaatacttaa aaggcttaaa agcggaaagc aagtagggaa gaaagggaga tattggggga 1561561 ggtcacatat gttgaatgcg cttacagaaa agcggacgcg cggatctatg ctttgggatt 1561621 atttgacgac ggtggaccat aaaaaaatcg caattcttta tttagtggca gggggattct 1561681 tctttcttgt cgggggaatt gaagcgatgt ttatcagaat tcagcttgca aagccggaaa 1561741 atgcgtttct cagtgctcaa gcgtacaatg aagtaatgac tatgcacgga acgacgatga 1561801 tctttctggc tgcgatgccg ctcttatttg ccttgatgaa tgcggttgtg cctttgcaga 1561861 tcggggctcg ggacgtttcg tttccatttt taaacgcgct tggtttttgg ctcttctttt 1561921 tcgggggcat tttcttaaat ctaagctggt ttttgggcgg agcgccagat gcgggctgga 1561981 catcatatgc ctcactttcg cttcattcta aagggcacgg catagacttt ttcgtcctcg 1562041 gactccaaat atcggggctc gggacgctga tagccgggat taactttttg gccacgatta 1562101 tcaacatgag ggctccgggc atgacgtata tgaggctgcc tttgtttaca tggacgacat 1562161 ttgtggcctc ggcattgatt ttgttcgcgt ttccgccgct tacggttgga ttggctctca 1562221 tgatgctgga tcggctgttc ggaaccaatt tctttaatcc ggagcttggc ggaaatacgg 1562281 tcatttggga acatttattt tggatcttcg gccacccgga ggtttatatc ctaattttgc 1562341 ctgcattcgg tattttttct gaggtcatcc ctgtgttcgc cagaaagcgt ttgtttggct 1562401 attcttcaat ggtttttgca atcgtgctca ttggctttct gggctttatg gtttgggtgc 1562461 accacatgtt cacgactggt ctcggcccga ttgcaaatgc gatttttgcg gttgcaacaa 1562521 tggctatcgc gattccgacc gggattaaga tttttaactg gctgttgacg atttggggag 1562581 gaaatgtgaa gtatacaacc gctatgctgt atgctgtctc atttattcca tcctttgtgc 1562641 tcggcggtgt gacgggagtc atgctggcag ctgctgcggc tgattatcag tttcatgata 1562701 cgtattttgt ggttgcgcac ttccactacg tcattattgg cggcgttgta ttcggccttt 1562761 tagccggtgt tcatttctgg tggccgaaaa tgttcggtaa aattctgcat gaaacgatgg 1562821 ggaaaatttc atttgtattg ttttttatcg gctttcacct cacgtttttc attcagcatt 1562881 ttgtcggctt aatggggatg ccgcgccggg tttatacgtt tttgccagga cagggtctgg 1562941 aaaccggcaa cttgatcagt acaatcgggg cgttttttat ggcggcagct gttattcttc 1563001 tgctggtcaa tgtcatatgg acatcggtaa aaggtgaata tgtaggtgct gatccatggc 1563061 atgacggacg tacgctggaa tggaccgttt cttcaccgcc gccggagtat aactttaaac 1563121 agcttccttt tgtcagagga cttgatccgc tttggatcga gaagcaggca gggcacaaat 1563181 caatgacgcc ggcggaaccg gttgatgata ttcatatgcc aaacggctca atcctgccgc 1563241 tcatcatttc cttcggcctt tttgtcgcag cgttcgggct gctgtacaga agtgattacg 1563301 cttggggcct gccggtgatc tttatcgggc tcggcatcac atttattacg atgctgcttc 1563361 gttcagtaat tgatgatcac ggctatcata ttcataaaga ggaactgccg aacgatgata 1563421 aaggggtgaa ggcataatgc aagttcaaga aaaattcacc gcagaaacct ttccagcttc 1563481 tcctgaaaaa gtaaccctgg aagggaaaaa taaattttta ggcttttggc tttttcttgg 1563541 cggagagact gttctgtttg cgtctctctt cgccacgttt cttgcgcttc ggaattcaaa 1563601 tgccggtgat ccgcctacga cggaaatgtt cgatgtgaca cttgtattca ttgccacaat 1563661 gcttctatta acgagcagtt taacgagtgt gtacgcgatg taccacatga agaacttttc 1563721 cttcggcaag atgcagcttt ggctgggaat tacgatttta ttgggggcgg gctttttagg 1563781 actggaaatc tatgagttca agcattacac ccatgaattt ggctttacca tcacaagctc 1563841 tgcccttggt tctgcgtttt acacgcttgt cggtacacac ggcgcccacg tggcatttgg 1563901 gcttatgtgg atcagcacgc ttatgatccg caatgccaag agagggctga atctgtatac 1563961 ggcgcctaag ttttacgttg ccagccttta ttggcacttt attgatgtcg tgtgggtctt 1564021 catctttacc gttgtatatt taatggggat ggtgggataa acatggtcga taaaaaaagc 1564081 agagggcata tcaatagcga ccttgaattt aagaaaaaaa agcatgcccg ggagatgaaa 1564141 tatcaagtcc tgtcttttgg tttaatgatc ggtcttacga ttgttgcatt tctgactgtg 1564201 gccacggacg gtgtcggcag ctggtttacg attcctttca ttattttgct agctgcaatt 1564261 caagtcattt ttcagctgta ttatttcatg catatgaatc agaaagggca tgaggcgccg 1564321 gcactgtttt tgtattcagg ggtgtttgtc gcgtttatca ctgtgcttgc gtttgtgaca 1564381 attatatggt ggtaatttga acagccgccg gaggtgaaga aatgaatcag ttggagatat 1564441 ttgggtttcg cgcgatgtgg agcccttatc ttttttgtat cctgttaggc attacggcgc 1564501 tttatctcta tttttacagg cgaatgtctt caaagccgaa tcgaataact ggtaaagaga 1564561 tggtgtgctt tctgtcggcg atgctgtttt tatatgcagc cgagggaagc ccggttgatc 1564621 tgctcggaca tattatgttc agtgcgcata tggtgcagat ggccgtcctg tatttggttg 1564681 tcccgccgct gttaatcgcg gggattcctg catggctctg ggaaaaaatc attttcaggc 1564741 cttcaatcaa accggttttt tcctttttta cgacgccttt aattgctttg cttttgttta 1564801 acggcatttt ttctttatat catgtaccgc ttatatttga tactgtcaaa acagatccgt 1564861 tttaccatac attaatcact tggcttatct ttgtgcttgc gttcttcatg tggtggccgc 1564921 ttgttcataa ggttgagcgt ctacggcagc tcagcggctt gatgaagctg ggttatatta 1564981 tggcggacgg tatgctgctc acacctgctt gcgccttgat catgttcagc ggtgcaccgt 1565041 tatacgccac ctatacagat ccggctttat gggctgaggc aatgaggctt tgcgtgccag 1565101 cggatatgat ggggcaggtc ccattaacag ggccagagat gttgaataca ctgcctttgt 1565161 tagaggatca gcagctcgga gcagtcatga tgaaaatcat tcaggaaatt gtgtacggta 1565221 cttttttggc cgttattttt ttccaatggg tgaagaaaga aagggaaaag gacgggcagg 1565281 aggagccgcc gtatattcag cagacgatat cataaaaggt acagcgaaat atgctgtacc 1565341 ttttcgttac atttgaactg tttttaacat gttggctatg tcctgaatca gtgccttgct 1565401 ttttgtcaca acctgtacgg gaaactcttc cgtttctcca tattctactc catgagggta 1565461 gtaatgcttt cctaggagag gggacattaa ttgaatcacg gcgcgcccgc ttccgacatc 1565521 gccttctgcc gcaatacctt gtatccgcag gtaaaacgta ccctcaatcg tcgaaaactt 1565581 cttgtcatag gtgactctct cgtaatccca ttgacccgct ctgataagac ctttgctttc 1565641 cattaagtcg tctagccagc tgagctcagc cttaacccct tcaagtccgc tttcagtaaa 1565701 cttcaacact gacccctcct tataaaaatt acctttcctg acaatcatag tatgaaagcg 1565761 ttaaactttc aatgaatctt cttcttttga aagtatgcaa aaattaaatt ttgacgacaa 1565821 tagcactaga ctaaaggagg ttaaacggat gacaaaaata aaagatctga tgacagccga 1565881 cttgcaatat tgcacggtat tagataatgt atatgaagct gcagtaaaga tgaaggacgc 1565941 aaatgtagga gcgataccgg tagttgatga ggacggggaa acattggtcg gcatcgtaac 1566001 cgaccgcgat ctcgtattaa gaggaatcgc catcaaaaaa ccgaactcgc aaaaaatcac 1566061 tgacgcgatg actgaaaaac ctgtcagtgt ggaggaagat gcttcagtcg atgaggttct 1566121 tcatttgatg gcatcgcatc agctcagaag gataccagtt acaaaaaata aaaaactgac 1566181 tggaattgtc acgcttggtg atctttcttt atctgagcaa acgaatgaac gtgccggcag 1566241 cgccttatcg gatatttccg aaggggataa tagagaagaa ggcttttttc attaacacat 1566301 aaatctttga catgttaaat aggctgtatt gtaatgggat gtaaacaaga gattgtgaat 1566361 cgccacgggg gtgatagatt gaaaaatata ttgagagcaa tggttatcct tttgattatc 1566421 tgcggaacct atgttctgtt tattcaatat ggatctgttc ctgaaaagaa atcaaatgac 1566481 agcgagcctc aggtgtcgaa tgaggaagcg caaagcggca aacgaataca tatgccgact 1566541 tcagggttat tgtccttcat gggcaagcac gccgatgaag taacgaaaaa gcttggggaa 1566601 cctgaacgta ttgacccttc ggcttatgat tacgattggt gggtatacaa tcaaggtaag 1566661 gatcaatata tccaaatcgg ggtattaaac aataaagtgg tcacattatt cgcgtcgggt 1566721 aatgatatta acgccaagcc tttcaaaatt ggagaatcaa ctggcgaagt attcaagacc 1566781 acccaggtgg caccatttgt gaatgtagag tataaaggaa attcctatcg gtttgaattt 1566841 tctgaagaag atatcaatac aagaccgact gtaaaggtag gaaagatgta tgtccagctg 1566901 tatatggaca aatttgaggg gaagctatcc agcatcaggg cgtttgatgc gcagaccttt 1566961 gtaaagcaaa gaccttatga ggtagtgtac cgcggggaat taattaaacc gaaagccgtt 1567021 tcagatgaga aatggaaaaa gatccaaaca acgagcgaaa agcaaatcct tgatttgacg 1567081 aatgtcatac gcgttaaaca tggacttgcg aagcttgagt gggatcagcc aacggcggaa 1567141 gtggcatttg ggcatagtga ggatatgaag gaaaataatt atttctccca tgtctctaaa 1567201 aaatacggct cgctgaaaga ccgcttagaa gaagggcatg ttgattttca gcaagcggga 1567261 gaaaatatcg catacaatta tgtggacggt ccggctgctg tagaaggctg gctgaatagc 1567321 gaaggccatc gaaaagcgct tctgaattca gattatacgc atcttggtgt cggagtagac 1567381 cggaaatatt acacccaaaa ctttattaag cgatggtaat gaaagccgcg gacgaatggt 1567441 tcccggcttt ttctatttcc atacaagctg gtctgaatga atgtgctgat agcttacaga 1567501 taaggccgtt tcccatccct tcagtcaggc tttttcacca gtgtataggg atatcgctaa 1567561 aaattcattt gggaatgaat ataggcgaac acaatgcccg acaaaacgat acattgtagt 1567621 aggtaacgat tttcggaggg ggtgaggatt gtggcgaatc aacatgccaa tcattcaatc 1567681 aatgacttta aacaattcgt caaaaagcat cccaagctga taaaagaagt gcgcaaagaa 1567741 caaagaagct ggcaggacgt atatgaaaat tgggtcctct tcggggagag cgacccgatt 1567801 tgggatccat atcgggaacc ggaagaagct tctgaagctg tgcctgaaac accgcaaaaa 1567861 aatgattttg tctcgaaaat ggtgacagcg gtgaaaaaga tggatgtcaa tcaaatgaac 1567921 gaacaaatca ataaaatgag ccagtcgatc tcatcgttgc aaagccttct taatacattt 1567981 tccggaagcg gacagaagca ttctcagcca ggctctggac agcatccttt ttcttttcga 1568041 aaggattaaa aaaggggagc tcatatgcgc aaagaggttc aggaatatat tttagcaaac 1568101 gaagaacgga aacgattcat cagagaacag ccgatatggt accgcaggct ttcaagaaaa 1568161 ccggatgatc tgtcctcctt tcagcttgaa atgatgaatt tttatgaaaa aaccattccg 1568221 catcgggtga atcagtttac gaacgggatt caaatggcgc aaatgatgat gcaaatgttt 1568281 caagcgatgc ggacaaaaga ttaaaaggcc ccgaagaagg gtcttttttc atgcggtcat 1568341 aaggttttgt tggcggctgc ggttaagcat tttccaattg gctggtttca tggtaaacta 1568401 acaactggag gtgcatgtta tgtatgcgac gatggaatcc gtgcggcttc aaagtgaagc 1568461 tcagcagctt gccgagatga ttctgcagtc ggagacggct gagaactacc gcaattgtta 1568521 caagcgtctc caggaagatg aagaggcagg tcggattatt cgttctttta tcaaaataaa 1568581 agagcagtat gaggatgtac agcgttttgg caaatatcat cctgactata gagaaatatc 1568641 ccggaaaatg agggagatca aacgtgagct ggacctgaac gataaggtgg ctgacttcaa 1568701 gagagctgaa aatgagctcc agtccattct tgatgaggtc agcgttgaga ttgggacagc 1568761 tgtttcggag catgtgaaag ttccgactgg gaacccttat tttgacggtt tgtcttcatg 1568821 cggaggcggc tgcggttcag gcggaagctg cggatgtaaa gtgtcctgac gagactggcc 1568881 gtctcgtctt ttacatataa gagaaaacag gcaggtgatt gtattggaga ataggcgcca 1568941 gggcatggtt gtgtatctgc actccctaaa gcagagcaaa atgctgagga agttcgggaa 1569001 tgtgcactat gtatcaaaac gattaaaata tgtcgtactg tactgtgata tggaccaaat 1569061 tgaaaaaaca atggacaaga ttgcgtctta ctcatttgtg aaaaaagtgg agccttctta 1569121 taaaccgttt ttaaaattgg aattcgagtc aaagcttgat aaggcaaaag aatacgatta 1569181 taaaatcggc atatagctat aaaaaaatcc ccgcaggcat ctgcggggtc cttctattcc 1569241 ttaatatgtt aaggagaagg caaagggaga ggagaaaccg gaggaagaac ttatggggaa 1569301 acgtaagtct tctccgcggt tggcaacaac atcctctaga tgctgttgct tatagtatgg 1569361 acaaggatca tgctgcctat acacctgttt atcaagatta gcgttcattg tttggaagaa 1569421 tgctttatgt taagatagga ttgatttttt tctatgtaca tagcggcgtc cggccgaata 1569481 aagaaacaaa atagctttta gaaaaagtgg tgtggaacat gagagtaatt tctggatcaa 1569541 aaaaaggccg ttcactaaag gctgtagccg gaacatcaac aagaccgaca accgacaaag 1569601 tgaaggaatc cattttcaat atgatcggcc cttattttga cgggggcagg ggacttgact 1569661 tattcgcagg gagcggaggt cttggaatcg aagcgctttc acgcgggttt gagcattgta 1569721 tattcgttga ccgtgatttt aaagcgattc aaacggtaaa atctaatttg aaaacgctgg 1569781 agcttacaaa acatgcacag gtataccgca atgatgcgga acgtgctttg cacgctgctg 1569841 ctaaaagaga aaccggcttt cgcggaattt ttctcgatcc gccgtataag gaacaaaagc 1569901 tgaaagcact tttaactttg attgacgaat atcaaatgct ggaagaagac ggctttatcg 1569961 tcgctgagca tgacagagag gtcgagcttc ccgaaaccgt aggagatctt gtgatgacaa 1570021 gaaaagaaac ctatgggtta acaggtgtag cgatttataa aaagaggggg tagtgaggtg 1570081 gcgagtatag ctgtctgtcc cggcagtttt gatcctgtga cctacgggca tctggacatc 1570141 atcaaacgcg gggcgcatat ttttgaacaa gtgtatgtat gtgtgctgaa taattcttca 1570201 aaaaagcctt tgttcagtgt ggaagaacgg tgtgagcttc tgagagaagt cacaaaagac 1570261 attccgaaca taacagttga aacatcgcaa ggcctgttaa ttgattatgc aaaaagaaaa 1570321 aatgcgaaag cgattttaag aggcttgaga gctgtatctg attttgaata cgagatgcag 1570381 gggacatcag taaaccgggt gcttgatgaa tctattgaga cgttttttat gatgacaaac 1570441 aatcaatatt cgtttctaag ttcaagcatc gtaaaagaag tggcaagata caacggctcg 1570501 gtatcagagt ttgtaccgcc ggaagtagag ttggcgcttc agcaaaaatt cagacaagga 1570561 tgagggtttt gactcatcct ttttttgttc cgtttgtcag tctgtaagaa aaaatgataa 1570621 tgtacgtaaa cagcgcgcat agtgtgacag caggtccgat ctgcacaagc agattccagc 1570681 cgtttataaa ggcagttgac atgtcactgc tgttaagaga tttaaataca tactgatacg 1570741 gatcatgcca tgctgtgtaa agaggtttcc ataaaagcat gacgaagaca gcggcataaa 1570801 cgccctgcag caaacgtgcg ataaagaatg gtttaaatct aatgtcggtt tccgataaaa 1570861 tacctgccac ctgagcttgt acggaaaagc cgctaaaccc aagaataaag ctgacgataa 1570921 tggctttttg cagaagagaa acatctgtct cgctgacaag cttgctgcct aatgtaattt 1570981 caaacatccc tgataaaagc ggaatgtcca attgagtcgg aagctgaaac aaagtcagtg 1571041 ctccttttgt gaaaacagac aaaacatcag tcagctggac cactgacaac agccgattga 1571101 agacagaaaa taaaataata aagccgccta ccataagaag cgtttgaaca gaagacgtca 1571161 cggcgtcgcc taaaatttta cctaagggcc gtttttctgc aagtctggcg gtatgaagag 1571221 cgtgtaaagc atctttgact gaagggaaag gtatcgtttt ctttcttctg agatgctgct 1571281 cttccttgcg gccataggag cgcattgtta aaccgacggc aagattcccc aaatagtgtg 1571341 cagaagctaa taaaatgcct agtgatgcgt tttgaaagaa accgacggca acagcgccga 1571401 aaataaagag cgggtttgaa gaattggtaa acgacgcgag ccgttctgcc tctactcttg 1571461 aaatctgatt ttcctgccgc agacgggcag tgagttttgc gcccgctggg tttcctgatg 1571521 ccattcccat agcaagaacg aagccgccga cacccggcac gcgaaagatc ggccgcataa 1571581 aaggctcaag caaaacaccg acaaaccgca caatgccaaa gccgattaag agttcggaca 1571641 gaataaaaaa tggcagcaat gacggaaaca caacctccca ccacatagac agcccggttt 1571701 tagaggcttc gaatgaggcc tgtggatgtg agatgacagt cgctgttaaa aaaagaaaaa 1571761 acgaggcaat caaaagtgta ttaatcttcg acaagttcat tcttacctcc ccgatgctaa 1571821 aaatgcccaa tgacatgtat atcatgataa aataatgtat gatgtaaaac ggccaagcag 1571881 tacctgtcct cttgattctt tgtactaata tacgagcata ggggttcagt ttagaccata 1571941 gaattcggta tacagggaat tcaggcagga ggttaacgct ttggccaaac ctaaaatcgg 1572001 gttagcgtta ggatcgggag gggccagagg gcttgctcat ctcggtgtgc tttccagttt 1572061 acataagcac caaattgaag tggatatgat tgcaggaagc agcatgggcg ctttggtggg 1572121 cagtttttac gccgccggac atgacgtggc aacgatgaaa aaagtagcca aagcctttaa 1572181 acgaaggctt tatgctgatt atacggtgcc gaaactcggt tttttaaaag gtgaccgcgt 1572241 cagacagctt gtgcatgctt atacattcgg aaaaccgatt gaagagctcc aaatcccgct 1572301 gggcattgtt gcgtgtgatc tacagacggg agaaaagatt gtgttccgaa aaggatcagt 1572361 gtcagatgca gtgagggcca gcatcagcat cccgggtatc tttattccgc agcggctgga 1572421 cggacgcctt cttgtagacg gcgcggtcgt cgatcgaatt ccggtttctg ttgtgaaaga 1572481 catgggagct gatattatca tcgcttcgga tgtttccagg gttcgaaaaa ctgaaacagc 1572541 agtgcatatt tttgatgtga ttatgcaaag tatggatata ctgcaaaatg aattagtgcg 1572601 gcatcaaaca attgccgcag atatcatgat tcgcccttcc cttgaaacat acagctcaag 1572661 ctcgtttgcc aatattgaag aaatgatatc ggcaggcgaa gaggcgacaa accgaatgat 1572721 cagcaagata agaaaagaaa tagagaattg ggagggctca taatttgcta cgtaaaaaac 1572781 attttagctg gatgctcgtc atcctcatac tgatcgccgt tttatcattt ataaaacttc 1572841 catactatat tacaaaaccg ggagaagcga cagagcttgc ttcattgata aaagtggagg 1572901 gaggctaccc ggaaaaagga agtctgtcct taatgactgt taaagtggga ccggctaatc 1572961 catttacata tgtgtgggca aagatgcacc cttattatga aattgttcct gatgagagca 1573021 ttaaggagga aggcgaatca gataaggagt atatgaaaag acagctccaa atgatgaaaa 1573081 gctcgcaaga aaatgcggtt atagccgcct atcaaaaggc aggaaaaaaa gtcagctatt 1573141 cctttaacgg catatacgca agctcagttg tagaaaacat gccggcaaaa gggaaaatag 1573201 aagtcggtga taaaatcatc agcgcagacg gcaaaaacta tcagtctgct gaaaagctga 1573261 ttgattatat cagcagcaaa aaagcgggag ataaagtcac gttaaagatc gaaagagaag 1573321 aaaaagaaaa gcgtgtcacc cttacgttaa aacaatttcc tgatgagccg gatcgggcag 1573381 gaatcggagt ttcgctttat acagacagaa acgtgaaggt agagcctgat attgattttg 1573441 aaatcgaaaa tattggcggc ccgtcagcag ggttaatgat gtcccttgaa atctataatc 1573501 agctgacaaa accagacgaa acaaaaggct acgatattgc gggaacaggt acgattgatg 1573561 ttgacggaaa agtaggcccg atcggcggca ttgatcaaaa agtcgtcgcc gcagacaaag 1573621 ccggaaaaga cattttcttc gcgccaaatc aaaacggcgc cagcaattcc gattataaga 1573681 acgcagtaaa aacagcaaaa gatattgatt caaatatgaa gattgtgcct gttgatacca 1573741 tgcaggatgc gattgattat ttgaataagc tgaaagcgaa aagcacctga ttctcaggtg 1573801 ctttttctat acatttaaaa agtgttgttc atcttcgtca tatcgaatcg gtgcatgtcc 1573861 gtattcctgt aggtcaaact cagttctcag cggctcttct atcggcaggc tgtaaatcct 1573921 gcttgctttt acgtccagat cgagagctgg atgggagaaa gaggacagtt tgctgacaag 1573981 cggaacagac agtgcttttt tcttttcgga taaataagcc tgtccttttt tcgtcatgcc 1574041 gagaagcctg atatacggcg ccttatcgtt gtcaagcagc ttttgcatat cctgtttttt 1574101 tgttctggtt aaaatgtgtg tattcatccg ctggagcctt gtccacgtat agcgttttgt 1574161 tttcagcagt tccataaatt cctgatagga gctggatttt ctgatcgaac gaataattct 1574221 gtgctctaaa ccttcctcca cctcgtatac ttgctgtaat tcccgtgccg ttacagttga 1574281 aaggctgtat tttaagtaag aaaagtagct ttcaggtgta tgccacaatc cgaaagattt 1574341 gcggtaagct gctaattcac gtgcagatgc agcagggaga aaacgaaggc aggcttcgag 1574401 attctggcca atcatcgctt ttctaatgct tgtggcactt gctatatggt tttcgccttc 1574461 agggagatcg gcatcatgat agtccgaaga gattcgtgcc gtagtataag gtttcatagg 1574521 atatcccccg gttagaatcg aggtcacata ctggtatccc aaaatgttat ttggttttga 1574581 caagtcaagt gcactttcag tatgcaaaat ggagctgaag gcgatagccg ccgctgctgg 1574641 gtaactggcc ccctttttaa gttcttcttt aattcggtca ttcaatatat gtttatgctc 1574701 atcaataagc tgtgctgttt ctaaaaaagg cttgatatcc ccattttcac tcccgaaaaa 1574761 cagcgcctca cattcaagtt cgttcaggat ggaaacactg ccgcgtgcaa aaatgtctgc 1574821 tttttgcacg gcataaagat aaggcagctc aatgacaaga tcaactccgc tttgcagcgc 1574881 catttttgtt cgggcccatt ttgatacaac agcgggttcc ccgcgctgta aaaaatgtcc 1574941 gctcatgacc gcgacagccg tgtcacatcc ggtttgcagc tttgctgttt gggcatgata 1575001 aaggtgaccg ttatgaaagg gattatattc aaccaccaat ccgacagctt tcatattttt 1575061 tccgcctttc ttgctatgtt taaaaacgta tggtacattt gcaaatgaaa actcttacgc 1575121 cttatttttg ttttaagtgt atgcatagca tattccgctg tcaacgatac ttcaatggca 1575181 gcattatgct gtaaagaaaa aatattgaca aaaacaatct taaaagctat aatcatgttt 1575241 gttgctttcc tgaggtgata caaatgaaat ggacgattta tcagctgcat caaatgccaa 1575301 aacaaagttt tgagtttgat gaaacagttg agttaaatga gctgacaaag ctgaattctg 1575361 acattcgccg catttctccc gttcgggtga agggcagagc ggatatcaaa tccaaacagg 1575421 tttcgtttga ttttacaatt tcaggcgaaa tgcttttgcc atgctcaaga acactcgttg 1575481 atgttccgta tccatttgaa atttcaacaa aagaactgtt tatatttcat cacacggatg 1575541 atatagaaga tgatgacgtt cacattgttg aggacgatac tatcgacata actccgatcg 1575601 tgaaagaaga aattctttta gaaatcccta tgcaaatctt ttgtgaatct gaacaagaaa 1575661 aaggagctgc tcctcaagaa ggaaaggatt ggcaagtcat ttcggaagaa gacaagaaga 1575721 atcaagttga tccgagactt gcagcccttg aaaagctctt aaaacaagat gatgaatctt 1575781 aactctttaa ggaggtggga ataatggctg taccttttag aagaacttct aaaatgaaga 1575841 aaagattgcg ccgtacacat ttcaaactta atgtacctgg tatgacagaa tgtccgtcat 1575901 gcggagagat gaagttgtct caccgtgtat gcaaagcatg cggatcatac aacggcaaag 1575961 acataaatgt aaaaagtaac taatgagaaa agcgcagggt gaaagccctg cgctttttct 1576021 ttttctcttc ctgtcagctt gcggaaaatt tgtgagtgca aatagtctat ctaatctatt 1576081 accggcatat gtatgagata aataagctga catggaggga gattgaattt gaccattaca 1576141 agacaagatg cttggactca ggatgaggat ttgctgctgg cagaagtggt gcttcgtcat 1576201 attcgagagg gaggaacaca gctttcagcc tttgaggagg ttggaagggc gctgaccaga 1576261 accgcggcag cctgtggttt caggtggaac tcgtatgtga gaaaacaata ccagtcaggt 1576321 atagagcttg caaaaaagca aaggaaagaa ctgagaaagc aaatcggcgt tcattcggtc 1576381 aatatgccga attccatgaa gcagactgcc tcggcatcgt cagaaggaaa acgagatttg 1576441 tccattcagg atgtcattca atttctcgaa caattcaaag aaacaccgtc tgcacaagaa 1576501 tttcagcttg aaagggaaaa attgaaggag caaatccaat cgctgcaaaa agagcttgag 1576561 gatttgcgga gtgaaaatca gacattgcgg aatcagctag agatgacaga agaggattac 1576621 aaggcactga tcgatatcat ggatcgggcc agaaaaatgg ttgtttcgaa ggaagacgga 1576681 agaatgaaaa aagcggctca agaaacgtaa agaaacgcct gaaatgaacc ggccctatag 1576741 taagaatagg ccggttgttt tgatttctat gcagactctc ccggtgtcat ttcgcgatcc 1576801 atatcaggat gccagatgag cgggttttcc cctttgtccc gcgccatatc atacttaaca 1576861 gttttaaagt tcattttgtt ccaaaattcc gctgatttca ttctcggatt tgtccggatc 1576921 ggcattttga atgattttgc aaattcaacc aaggctctcc cgtatcccct gttctggtag 1576981 cccggaagaa cctcaagctt ccacagctcc aaataatcct ggcggttgtc aaaataggga 1577041 ttcgatttgc cgttaacttg atacagactc attcgtgcta caagtttatc gccaaaataa 1577101 atcccgtaaa aaggcgaggt gctgtcattt tcaataatat tatcctgaag ttcttcaagc 1577161 attgaaagct cctgaatgcc gtattctttg aatttcttga attcttccag cgttttatag 1577221 ttgataagca gacgttctac ctttgtcaaa caaatctccc cctttgttgt ttctacatat 1577281 attgtaaacg ctttatttaa aaaatccaaa tatttaaact ttaattttaa gcacatggga 1577341 tctttgagaa gtaatttctt cttacttctg ctatgataat acgtaaatgc taaattgggt 1577401 gtgacatcat gaaaattgga attatcggcg gaggctccgt tggtctttta tgcgcctatt 1577461 atttgtcact ttatcacgac gtgactgttg tgacgaggcg gcaagaacag gctgcggcca 1577521 ttcagtctga aggaatccgg ctttataaag gcggggagga attcagggct gattgcagtg 1577581 cggacacgag tatcaattcg gactttgacc tgcttgtcgt gacagtgaag cagcatcagc 1577641 ttcaatctgt tttttcgtcg cttgaacgaa tcgggaagac gaatatatta tttttgcaaa 1577701 acggcatggg gcatatccac gacctaaaag actggcacgt tggccattcc atttatgttg 1577761 gaatcgttga gcacggagct gtaagaaaat cggatacagc tgttgatcat acaggcctag 1577821 gtgcgataaa atggagcgcg ttcgacgatg ctgaaccaga ccggctgaac atcttgtttc 1577881 agcataacca ttcggatttt ccgatttatt atgagacgga ttggtaccgt ctgctgacgg 1577941 gcaagctgat tgtaaatgcg tgtattaatc ctttaactgc gttattgcaa gtgaaaaatg 1578001 gagaactgct gacaacgcca gcttatctgg cttttatgaa gctggtattt caggaggcat 1578061 gccgcatttt aaaacttgaa aatgaagaaa aggcttggga gcgggttcag gccgtttgtg 1578121 ggcaaacgaa agagaatcgt tcatcaatgc tggttgacgt cattggaggc cggcagacgg 1578181 aagctgacgc cattatcgga tacttattga aggaagcaag tcttcaaggt cttgatgccg 1578241 tccacctaga gtttttatat ggcagcatca aagcattgga gcgaaataca aacaaagtct 1578301 tttgagcttt ttcggtaaca tgctatactc atttcggatc actaactatt tattggagaa 1578361 aggaagttct agaagatgca gctaactgaa ctttccatca aaaatcagaa tgtgtttgta 1578421 cagcactata tagatggcaa agaagaaatg tcttcttttt ttgattacag tattcatcat 1578481 aaggacatgt ggcgcgaaag actggaagac ttatcttccc ggtttttcgc aagagaggaa 1578541 ttggcggcgt acttaacctc ttaccataat aaattcggtt caagtgcgat gcagtctgct 1578601 attgagaagc tgaaggaccc gtcaagtgcc gctgtagtcg gcggacagca ggcaggactt 1578661 ttaacaggac cgctttacac catacataaa atcatttcaa tcattgtttt agcaaagcaa 1578721 caagaaaagg aactgcaagt gcctgtcata ccaatcttct gggtggctgg agaagaccac 1578781 gatttggatg agattaattt tgttcacaca tctgaagaga atgggcctgt gaaaaaaaag 1578841 ctgcctcagt cttattggaa gaaatcatca gcagcgagta catcgcttga tcaggaaaag 1578901 tgtgccgcgt ggatagatga tgtttttgcc gcttttgaag aaacagacca tacgaataca 1578961 cttctcgaca atgtgaaacg atgtttaagg gaatctgtta cgtttactga cttctttgaa 1579021 ctgctgatcg cggatttgtt ccaagaagag ggcttagttt tattaaattc tggggatccg 1579081 gggattaaaa agctggaaac ggccatgttc caaaagattc ttcgagaaaa tgatgaactc 1579141 gcccgggctg tatcagatca gcaggccttc atgcgtcaag caggctacaa accgattatc 1579201 gagtccggaa aagagcaggc gaatctgttt tatgaatacg aagatgagcg ttttttaatt 1579261 gaaaaagata acggccgatt tgtcatcaaa gagcttgatc taggatggac gagggatgaa 1579321 cttcatacac atatggaaga acatccagag cgtttcagca acaatgttgt aacgagaccg 1579381 ttaatgcagg aatttctcat tccgacttta gcatttattg cagggcctgg ggaaatcaat 1579441 tattggggcg agctcaaaca ggcatttgcg gtgatgggct tcaaaatgcc tcctgtcatg 1579501 ccaaggctga acattacgat acttgagcgg catattgaga aaaaactggc tgaacggaat 1579561 atctcattac aagacgcgat tgagcgcgga acggagaatc aaagagagac atacttcgag 1579621 cgccagattc cggaagagtt tacggcggtg atggatcagg cgaaaagcca aattgaagcg 1579681 attcacaaaa cggtccggca ggaggcgtta aaggttgatc aaagcttgga acctttactt 1579741 ctgaaaaatg ccgcttttat tcaggatcag cttcaattct tagagcgcac ggtgatgaag 1579801 cgaattgaag aaaaagaagg ctacgtcttg aaggattatg aaagaattca aaatagcatt 1579861 aagccgcttc ttgcgccgca agaacggatt tggaatatca tgtattattt gaacaggtac 1579921 ggtccaaaat tcttcacgac attcaagaat ctgccatttt cttttcaaaa tcaacatcaa 1579981 gttgtcaaac tttgaaataa agttttaaag aaccctgact agttcagggt ttttttttat 1580041 gggtaaacag tgtaaaatga agttgtggag cgaagtggtg aatagtggtg agttaaggag 1580101 agaaagtggg gcaagagatc atgtttatgg gtgaatatca gcataccatc gatgcgaaag 1580161 gccgcatgat cgtacccgct aaattcagag aaggcctagg tgagcaattt gtgctgacta 1580221 gaggacttga ccaatgtctc ttcggctacc ctatgcacga atggaaacaa attgaagaaa 1580281 aactaaaagc tcttcctctc acaaagaaag atgcccgcgc gtttacccgt ttcttctttt 1580341 caggggcgac tgaatgcgaa ctggataagc aaggcagggt aaatatcgca tcatctctat 1580401 tgaattacgc caaactggaa aaagaatgtg ttgttatcgg ggtttctaat cgaattgaat 1580461 tgtggagtaa agtaatttgg gaacaataca cagaagagca agaagattca tttgctgaaa 1580521 ttgctgaaaa catgattggg tttgatatat aatgattctt cgtgtataac actctaaaaa 1580581 caatttcaat tcatcctgat aaaaggtggg accaacacaa tatgtttcaa cacaagacag 1580641 tacttcttcg tgaaaccgta gacggactta atattaaacc agacggtaca tatgtagact 1580701 gcacactcgg cggagctggg catagtacat acttattgca gcagttatcc gagaaggggc 1580761 gtttaatcgc ttttgaccaa gatgatacgg cattacagca tgctaaagaa gtgttgtccg 1580821 attataaagg acagctcatt ctgattaaaa gcaatttcag gtatttaaaa gaatatttga 1580881 atgaacaagg cgttacagaa gtagacggca ttttatttga tttaggggtg tcctctccgc 1580941 agctggatac accggagcgc ggattcagtt accatcatga cgcaccgttg gacatgagga 1581001 tggaccagtc ggctacgctt tcggcgaaag aagtcgttaa tgagtggcgc tatgaggatc 1581061 tcgtccgtat tttctttaaa tacggagaag agaagttcag taaacagatc gccagaaaaa 1581121 ttgaggaggc aagaatgaag tctcctattc aaactacggg ccaactggtc gatctaataa 1581181 aagacgcgat tcccgctcca gcgagaagga gcgggggaca tcccgctaaa cgcgtgtttc 1581241 aggcaatcag aattgccgta aacgatgaac ttagggtgtt tgaagaagct ttggagcagg 1581301 caattgaggt tctgaagcca gggggcaggg tatcggtcat taccttccac tcgctagaag 1581361 acagaatttg caaaaccact tttaaagaaa agtcgtcgct tccggaactt cctccgggac 1581421 ttcctgttat accggaagag tttgaaccgg agctgaagct catcacacga aaaccgatta 1581481 cggcatctca agaagagctt gaagagaaca accgggctcg ttctgccaag cttcggattg 1581541 ctgaaaaaag aaaataacga aacgcgaacg caaaattaaa aggaggtcat cagcctatga 1581601 gcaatttagc ttaccaacca gagaaacagc agcggcatgc gatcagtcct gagaaaaaag 1581661 tgattgtcaa gaaaagggct tccattactc tcggagaaaa agtgcttctt gtcctctttg 1581721 ctgcggcggt gctcagcgta tcgcttttga tcgtatcgaa ggcgtatgcg gcatatcaaa 1581781 ccaatattga ggtgcaaaag cttgaggagc aaatttcatc cgaaaataag caaattggtg 1581841 acctcgaaaa aagcgttgct gatttaagca aaccgcagcg cattatggac attgcgaaaa 1581901 agaacggctt gaatttaaaa gataaaaaag tgaaaaacat acaggaatga ttcaaatgcc 1581961 aaaaaagaat aaatttatga atagaggagc agcgattcta agtatttgtt tcgctctctt 1582021 tttctttgtc atcctgggga gaatggcata tattcaaata accggaaaag cgaacggcga 1582081 agtgcttgcg acaaaagcga cagagcagca tgaaaagaaa cggaccatcg aagcgagccg 1582141 cggctcgatt ttagaccgaa aaggaaaagt cattgcagag gacacagcga cgtataaact 1582201 gattgcgatt ctcgataaaa aaatgaccac tgatgtcaag catcctcagc atgttgtaaa 1582261 caaagaaaaa acggcggaag cattgtctaa agtgataaac ttggacaagg ccgacatcct 1582321 tgatatctta aataaagatg caaaacaagt cgagtttggc tcagctggcc gggatattac 1582381 gtattcacaa aagcaaaaaa tcgaaaaaat gaaactcccg ggcatttcat ttttacggga 1582441 tacaaaacgc tactatccaa acggagtatt tgcatctaat ctaatcggct atgccgaggt 1582501 tgatgaagaa acaaatgaaa tttccggcgc gatgggatta gaaaaagtgc tggataagta 1582561 tttgaaggag cgggacggat atgtgacata tgaaagcgac aaatccggct gggagctccc 1582621 gaacagcaaa aataaaatta cagcgccaaa aaatggtgac aatgtatatt taaccattga 1582681 ccagaaaatt caaacctttt tggaagacag catgacaaaa gtggcgcaaa agtataatcc 1582741 gaaaaaaatc atggccgcag tcgttgatcc gaaaacgggc aaagtccttg ccatgggaca 1582801 gcgcccaagc tttgatccga acaagcgcga tgtgacaaac tactataatg atttgatttc 1582861 atatgcgtat gaacccgggt ccacgatgaa gatctttaca ctcgctgctg cgatgcagga 1582921 aaacgtgttt aatgcgaacg aaaaatataa atcagggaca tttgaagttg gcggagcacc 1582981 tgttaaggat cacaataacg gtgtaggctg gggtccgaca acatatcatg acggcgtcct 1583041 aaggtcgtcg aatgtcgctt ttgcgaaact ggcgaaagaa aagctgggat atgaccgcct 1583101 caatcaatat ttgcacaaat tcaattttta ccagaaaaca ggtattgatt tgccaggaga 1583161 agtctccagc aaaatcaact ttaaatatga atttgataag gcgtcaactg catatggcca 1583221 agcgtctgcg gtcacaccaa ttcagcagat tcaggccgca acggcaattg caaatgacgg 1583281 taaaatgatg aaaccttatg tcattgacca tatcgttgac cctgataaag ataaaactat 1583341 ttatcaaaat aagccggaat cagccggaac tccaatttct gcaagtactg cgaaaaaggt 1583401 gcgggatata ttaggagaag tcgttacatc gaagatcgga acagggcaag cttataaaat 1583461 cgaaggtttt gatgttgccg ggaaaacagg tactgcgcaa atagccggta aaggcggata 1583521 tttagacggc acagataact atatcttttc gtttatgggt atggcgccaa aagatgatcc 1583581 tgagctttta atttatgttg ctgtacagca gccgcaacta aaagcaggac aaagcagttc 1583641 agatccagta tcagaaatct tcaatccaac aatgaaaaat agcctgcact acctaaacat 1583701 cgaaccaact gaaaaatctg actcagataa ggaagaaaca aaagcgcaga caatgcctga 1583761 tttaacagat caaacggtag ctgctgctca aaagaaagca aaagaggaga atctcacacc 1583821 aattgtcatc ggcagtgatg tcgctgtaaa agaacagtat ccgaaagcgg atgaggaagt 1583881 tctcaccaat caaaaggtct tcctgaaaac gggcggcaaa atcaaaatgc ctgatatgac 1583941 aggctggtcg agaagagagg ttctgcagta cggcgagctc gcgggaattc atattgaagt 1584001 aagcggacaa ggctacgctg tcagccaaag tgttaagaaa gacaaagaaa tcaaagacaa 1584061 aaccgtaatc aaggttaagt ttaaaaatcc tgattaaaaa gaaagccgtc gttatgcagg 1584121 ctttcttttt ttatgccttc agaggagcat cgttctacct gtccaaattc aggcataaaa 1584181 tgaaacaagc ctaaataagg agtgaacggt ctcttgcgcg tctcgaatgt aacggttaga 1584241 aaacgtttat tatttgtttt gctttttggc gtgatcgtgt ttctgatcat tgatacaagg 1584301 ctggggtatg ttcagtttgt gatgggcgaa aaactgactt cgctagcgaa agattcctgg 1584361 agccggaact tgccgtttga gccggagaga ggcgagattc tggatcggaa tggtgtgaag 1584421 ctcgcaacaa ataaaagtgc gccgaccgta ttcgtcgtgc cgcgccaagt tcagaatccg 1584481 atgaaaacga gcaagcagct tgcggcggtg ctcaatatgt cagaagaaaa agtatataaa 1584541 catgtgacaa aaaaagcgtc aatcgaaaag atcactcctg aagggagaaa aatttcaaat 1584601 gagaaggcga aagaaatcaa agcgcttgat ttaaaaggtg tgtatgttgc ggaggacagt 1584661 atccgtcatt acccgttcgg cagcttttta tctcatgtgc ttggatttgc aggaattgac 1584721 aaccaagggc tccttggact tgaagcctat tacgacgatg atttaaaagg ggaaaaaggt 1584781 tctgttaagt tttatacaga tgccaagggg aagaagatgc ctgatgaagc ggatgactat 1584841 acgccgccta aggatgggct tgatatgaag ctgacagttg attcaaaggt tcagacgata 1584901 atggaaagag agcttgataa cgctgaggcc aaatatcatc cggacggcat gattgccgta 1584961 gccatgaatc cgaaaaacgg agaaattttg gggatgtcta gcaggcctga cttcgaccct 1585021 gctgattacc aatctgttga tccgtccgtc tacaatcgaa atctgccagt atggagcacg 1585081 tatgaaccgg gatctacctt taaaattatt acacttgcag cagcccttga agagcaaaaa 1585141 gtaaatttga aacgggatca attttatgat aaagggcatg ctgaagtgga cggagcgaga 1585201 ctgcggtgct ggaaaagagg cgggcacggg ctgcagacgt atctggaagt tgtgcagaac 1585261 tcctgcaacc cggggtttgt tgaattaggc gagcgcttag gaaaggaaaa gcttttcaaa 1585321 tatatcaaag actttggttt tggacaaaaa acggggattg atctccaagg cgagggaaca 1585381 ggcatcttat tcccgcttga gagagtgggc ccggtggagc aagcaactac ggctttcgga 1585441 cagggagtat ccgtcacgcc gattcagcag gttgcagcag tatccgccgc tgtaaacgga 1585501 ggaacgctct atacacctta tattgcaaag gaatggatcg atcctgttac gaagaaaacg 1585561 gtcaaaaaac aatcaccaat cgcaaagaaa caagtcattt ctgaggaaac atccaaacaa 1585621 atccgctatg ctctagaaag cgtcgtcgca gaaggaaccg gccgcaatgc atttgtagaa 1585681 ggatatcgtg tcggaggaaa aacgggaact gcacaaaagg ttaaagatgg aaaatatctt 1585741 gaaaacaacc atattgtatc atttatcggt ttcgcgccag cagatgatcc gagtctagtc 1585801 gtctacgttg cggtggataa cccgaaaggc acgattcagt ttggcggaac ggtggcagcg 1585861 cctattgtcg gaaatattat gagagacagt ctgccggaac ttggtgtgaa gccccggaaa 1585921 aatcaaatcg agaaaaaata ccaatggaac gacacaaaaa caatagaagt tccgaatgtt 1585981 gtagggatgt ctgtctcaga tcttgagtca ctattggtga atctcaatgt ggatgcttcc 1586041 gggaaaggga gcaaaatcgt taaacaatcg ccagctgccg gaacgaaagt aaaagaaggc 1586101 tcaaagatac gcgtgtattt gactgaagaa gatgaaaagg aggcagccga ttgattcggg 1586161 ctgcctattc ttttattgca gaaaaaatgc tgatatcttt caagattagc tggatgtatc 1586221 cttttattta cgctaaaata tgaactgtat gcttaaaatc attaccacat catttgatgt 1586281 gacttcaatg ataaaaagaa cgaattagaa tgttgagagg tttgatacga tgaaacttac 1586341 aaagctgctt acatacttaa caaccgaacc ttctgtaaac gactcacaag accctgaaat 1586401 aacttcaatt gagatggact ccagggaagt aaagaaaggg agtctttttg tatgtgtaaa 1586461 agggtatacg gtggatggcc acgattttgc gcaaaaagca gtagaaaacg gtgcagcggc 1586521 tattgtggca gaaagagagg tcgatgtgaa tgttcctgtt attattgtcc ggcagtcact 1586581 tcgcgcgctc agcgttttgt ctgatgcgtt ttacggacag ccgacgaaga agcttcagct 1586641 gattgggata acagggacaa acggcaaaac atcaacgacc cacatggtcg atgagattct 1586701 gaaaaaagcg ggaaaacgca caggcttgat cggtacaatg tacatgaaaa tcggagacga 1586761 aacacttcct gttaaaaaca cgactccgga aagcgtcacg ctgcagaaaa cgtttaagaa 1586821 aatgaatgac aagcacgttg acactgcaat catggaggtt tcttcccacg ctttgtcttt 1586881 aggacgcgtc catggctgtg attatgatat tgccgtgttt acgaatttaa cacaggacca 1586941 tctggactat cataaaacga tggatgagta ccggcatgca aaaagcttgc tcttttccca 1587001 acttggcggg gctttcaacc atgaacatcc aaagcgtgcc gtcctgaatg ctgacgatga 1587061 ggcgagcgct tattttgaaa aggtaacagc tgcgcatatc tctacatacg gaattaaaaa 1587121 cgatgctgat gtgatggcga agaacatcag tatcactgca cagggcacaa gctttgatct 1587181 cgtgacaaac aaaggcacga agcacatcac gatgtctctc gtcggacaat ttaatgtgta 1587241 taacgtgctg gccgctgttg cgacatgtat tgcagcaggc ataccgtttg aaatcatcac 1587301 tgaggctgtt gaagaattgc atggtgtaag aggccgtttt gaattggtca atcagcagca 1587361 ggagtttcct gtcattgtag actacgcgca cacaccggac agccttgaaa atgtgctgga 1587421 gacatgcaga gacatgacgg aaggaaagct atttgtcgtt gtcggctgcg gaggagacag 1587481 agataagacg aagcgcccga aaatggctaa aattgctgtg gagctggctg acgagccgat 1587541 tttcacgtca gataacccga gaagcgaaga tcctcgcgcg attttaagag atatggaagc 1587601 cggagtagag aacgcatact atcacagtat tgcaaaccgc gagcaggcga tctttttcgc 1587661 aattgccaat gccaaaaaag gcgacgttgt cctcattgcc ggaaaaggac atgaaaccta 1587721 tcagcagatc ggaaatgaaa ctttcgattt tgatgatgct gaagtagcgg cgagagccat 1587781 tgttgaactc aataagaata agacgaattc ataggaaaga gatgttactg aataatggag 1587841 cttgaaaaga tttttcatat ggaaaaaaat catgaatatg ataactacgt atgtcgtttg 1587901 aaagaaacag gaggagaaaa ggacaatgct tgagcaagtc attctgttta caattttaat 1587961 ggggttttta attagtgttc tgctctctcc gattcttatt ccgtttttaa gaagattaaa 1588021 attcggccag agtattagag aagaaggacc gaaatcacat cagaaaaaat cagggacacc 1588081 gacaatgggc ggggtcatga tcatactttc tatcatagtg acaacaattg ttatgacaca 1588141 gaagttttca gaaataagcc ccgaaatggt gctgcttctg tttgttacgc taggctacgg 1588201 tttgcttggc tttttagatg attacatcaa ggttgtcatg aagcgcaatc ttggattgac 1588261 atcaaagcaa aagctgatcg gacaaattat tattgcggtt gtattttacg ccgtgtatca 1588321 ttactacaat tttgcgacgg atattcgcat tcctggaact gacttatcat ttgatcttgg 1588381 ctgggcttac tttatccttg tgctctttat gctagtcggc ggatcaaacg cagttaacct 1588441 gactgacggc cttgacgggt tattatccgg tactgcggcg attgcctttg gcgcctttgc 1588501 cattctggca tggaatcagt ctcaatatga cgtagcgatt ttctcagttg ccgttgtcgg 1588561 tgcagttctg ggcttccttg tatttaatgc tcatccggcc aaagttttta tgggagatac 1588621 gggatcgctt gcattgggag gagccatcgt taccattgcc attttaacga aattagagat 1588681 cctgctggtt atcatcggcg gtgtattcgt tatcgagaca ttatccgtta ttttgcaggt 1588741 catcagcttt aaaacgacag gtaaacgaat ctttaaaatg agtccgcttc atcaccatta 1588801 tgagcttgtc ggctggtctg aatggagagt agtcgtgacg ttttgggctg cgggactttt 1588861 gcttgccgtt ttaggaattt acatcgaggt gtggttataa gtggaaaatg atcaattttt 1588921 acagaaacag cattttttaa tccttgggct tgcgaaaagc ggatatgcgg cggcctccat 1588981 tcttcatgaa aaaggcattt atgttgcagt caatgatcaa aagccttttg aagaaaatga 1589041 accggcacaa aagctttctg aaaaaggaat cgaagttgtt tgcggagagc atccagtttc 1589101 tctgttcgat cagcatcaaa tcacgattct gatcaaaaac ccgggaattc cttatgaaaa 1589161 tatcatggtt caggaagcag agaaacgagg tattccggtt tggacggaaa ttgagctcgc 1589221 ttactacctg accagcgcca agtttatcgg gattaccgga tcgaacggta aaacgaccac 1589281 gacaacgcta atttacgaaa tgctcaaggc tgactcgcaa aaagcactga ttgccggaaa 1589341 catcggcaca gtcgcaagtg aggttgccta tcatgctgat ggagatgaat ggatcgttac 1589401 cgaactgtct tcgtttcagc tgatgggaac acacgctttc agaccggaaa tcagcctgat 1589461 tttaaatgta tttgacgccc atctggatta tcaccatacg cgcgaaaact atgaaaaagc 1589521 gaaacagaaa gtgtaccttc atcagactgc ttcagataaa gctattgtca accaggatga 1589581 tgaaaccgtc gtgcgtcttg ctgaagccgg aaaagccgaa atcgtcccat tttcagtcag 1589641 caaaacgctt gaacagggcg catatgtaaa agacagtatg attatgttta acggcgaagc 1589701 cattcttcct ctggaagagg ttgtactgcc cggtgctcat aacctggaga acattttagc 1589761 agctattgca gttgtgaaaa cggcaggagc atccaatgag gcggttaaaa aggtgctgac 1589821 aagctttact ggtgtgaagc accgcctcca atatgtcaca actgtgaatg gccgcaaatt 1589881 ttataacgac agtaaagcaa caaacattct ggcgacaagc aaggcgcttt cagcttttga 1589941 taagccggtc attctgcttg cgggcggact ggatcgcgga aatggttttg atgacttgaa 1590001 accttatatg aagcatgtca aagcagtgct tacatttggc cagacggcgc caaaactcga 1590061 gaaactcggc aatgaactgg gaatacaaca tgtcaaacgt gtcgataatg ttgaacaagc 1590121 agtatctgcg gcgtttgcgc tctcaaatga aggagatgtc atcctgctgt cacccgcgtg 1590181 tgcgagctgg gatcaattca aaacatttga agaacgcggt gacatgttta tagatgccgt 1590241 gcatatgctt aagtaagggc ttgtcttgaa gtaaatcggc agccctaatg actttaagct 1590301 tggggtgtcg attgctttga ctactaaaaa aacatcgcct gatttgttat tggtcatcat 1590361 tacgttatta ttattaacaa tcggattaat tatggtgtac agtgcgagtg cggtatgggc 1590421 ggattataaa tttgacgact cattcttttt cgcgaaacgg cagcttttgt ttgcgggaat 1590481 cggcgtcatt gctatgtttt ttatcatgaa tgttgattat tggacttgga ggacatggtc 1590541 caaattgctg atggttatct gctttttcct tctggtgctt gttttgatac cgggcgtcgg 1590601 aatggtgcgg aacggttcaa gaagctggat cggagtcgga gcattcagca tacagccttc 1590661 agagtttatg aagcttgcga tgattgcatt ccttgctaaa tttctctctg aaaaacaaaa 1590721 aaacatcaca tcgttcagac gggggttcgt ccctgcactt ggcatcgtgt tttcagcatt 1590781 tttgattatc atgtgccagc ctgacctcgg aacggggaca gttatggtcg gaacttgtat 1590841 tgtcatgatt tttgtagccg gcgcacggat cgcccatttc gtctttctcg ggctgatcgg 1590901 cctcagcgga tttgtcgggc tcgtactatc ggctccatat cggataaagc ggattacctc 1590961 atacttaaat ccatgggaag acccgctcgg aagcggattt cagatcattc aatcgcttta 1591021 tgcagtgggg cccggcgggt tgttcggaat ggggctcgga caaagcagac agaagttctt 1591081 ttatctgcct gagccgcaaa cagactttat tttcgccatc ttgtcagagg agctgggctt 1591141 tatcggggga acacttattt tgctcctctt cagcgtcctg ctgtggagag gaatcagaat 1591201 tgcgcttggt gcgcctgatc tgtacggaag ctttgtcgca gtcggcatta tttcaatgat 1591261 tgccattcaa gtcatgataa atatcggcgt agtcacgggc ctgattcctg taacaggcat 1591321 cacgctcccg tttctgagct acggaggctc ttcattgact ctaatgctga tggcagttgg 1591381 tgtgctgctg aatgtaagcc gctactcgag gtattaacga atgtatttcc aagcctcctg 1591441 tctaacatga agcttggaaa caattgatgc gataaccctg tccaacaaaa cagggttatc 1591501 gttatgttat agagaaactt agactggggg aaaaaagaaa tgcgaattgc aataagcgga 1591561 ggcggtacag ggggacatat ttatcctgct cttgctttta ttaaagaagt gcaaagacgt 1591621 catcctaatg tggaattttt atatatcgga acagaaaacg ggctggagaa aaaaattgtt 1591681 gagcgggaga atataccgtt tcgttcaatt gaaattacag gatttaaaag aaaattgtca 1591741 tttgaaaatg tcaagactgt gatgcgtttt ctgaagggcg tcaaaaagag taaatcgtat 1591801 ttagcggaat ttaagcccga tgccgtaatt ggaacgggcg gttatgtatg tgggccggtt 1591861 gtctatgccg ctgcgaaaat gggaattccg actattgtcc acgaacaaaa cagcctgccg 1591921 ggcatcacga ataagtttct ttcaaaatat gttaataaag tagcgatttg ttttgaagaa 1591981 gcgaaatcac attttcctag cgagaaagtt gtatttacgg gaaacccgag agcctctgaa 1592041 gtcgtctcaa taaagacggg acgatcattg gctgaatttg ggctttctga agacaaaaaa 1592101 acggtcttaa ttttcggcgg aagccgaggc gctgcaccga ttaaccgcgc tgtcattgac 1592161 atgcaggatg tgctgaaaac aagagactat caagtgctgt atatcaccgg tgaagttcac 1592221 tatgaaaaag taatgaatga gctgaaaagc aagggtgccg ctgataatat ggtcacaaag 1592281 ccgtttcttc atcaaatgcc tgagtattta aaggccattg atgtcattgt ggccagagcc 1592341 ggtgcgacaa cgattgccga aattactgct ctcggaatcc caagtgttct gatcccaagt 1592401 ccatatgtga cagcgaatca ccaggaggtc aatgcgaggt ctcttggcca gcatgatgcg 1592461 gcgattgtac tgaaagaaac agagctcagc ggggagaagc tgattgaagc gctagaccgg 1592521 attgtactga atgagcaaac gttaaaggaa atgagcgaac gaacaaagtc actcggtgtt 1592581 cctgacgcgg ctgcccgttt atacagcgta ctcgaggaat taaaaaaata gtagaaaagc 1592641 aaatggaatg cggaggttta cgatggagaa agtgatacag gaattaaaag aacgagaagt 1592701 cggcaaggtt cttgcaaatg aaccgctcgc gaatcataca acgatgaaaa tcggcggacc 1592761 tgcggatgta ttggtcattc caagcagtgt ggatgctgtt aaagacatca tggacgtgat 1592821 taaaaaatat gatgtgaagt ggacagtcat cggccgcgga tcaaatcttc ttgttttaga 1592881 tgaaggaatt agaggcgtag tgatcaagct gggggcgggt cttgaccatt tggagcttga 1592941 aggggaacaa gtaacagtcg gaggcggtta ttcggtggtc cgccttgcta catcattgag 1593001 caaaaaaggc ctgtccggtt tggaatttgc tgccggcatt ccaggatcag tcggcggagc 1593061 ggtttatatg aatgccggcg ctcacggttc tgatatgagc gagatcctcg tcaaagcgca 1593121 tattttattt gaagacggaa cgattgagtg gctgacaaat gagcagatgg atttcagcta 1593181 caggacatct gtactgcaaa agaaacgccc gggcgtttgc cttgaagctg ttttgcagct 1593241 tgagcagaag gataaggaat caatcgttca gcaaatgcaa agcaataaag actatagaaa 1593301 aaatacacag ccgtattcaa gcccttgtgc gggaagcata ttcagaaatc cgcttccgaa 1593361 tcatgccggg aaccttgtag aaaaagcagg cttgaaagga tatcaaatcg gcggtgcaaa 1593421 gatatcggag atgcacggaa acttcatcgt caatgcgggg ggagcatcag caaaagatgt 1593481 gcttgatctc attgaccatg tgaaaaagac aatccgtgaa aaatacgaga ttgatatgca 1593541 cacagaggtt gaaatcatcg gcggaaatcg ctgattcaag ttctgactga agctgttcat 1593601 atgatatact gtaagcaaac gacaaacggc atcatagtat gccgtttgtt ttggaataga 1593661 cagactttta acagctgttt catttgaatg aggtgaacag gcaatgaacc cgggtcaaga 1593721 ccgagaaaaa atcgttaaca ttgaagagcg gatccctaaa attaaagagc agaggaaaca 1593781 aaaggcaaac cgccgtctca tttcatttat tatgctcttt tttattatgg tgctgatcat 1593841 tgtgtacctg caaacaccaa tcagtaaagt atcaacaatc tctgttacag ggaatgaaaa 1593901 tgtatcaaaa aaggaaatta tcgacctttc cgatattaac agcggagata ctgagttttg 1593961 gagtttggac aagcaaaaaa cagaaaagaa gattcagcaa aataaattag tgaaaaaagc 1594021 ggagatcagc aaatcgcttc ctaataaaat caacattgca atcgaagaat ataaagcgat 1594081 tgcttattta gaaaaagacg atgtgtacta tgaagtgctt gaaaacggct cagttctgcc 1594141 aaacgaagta acgccggatg atgccggacc gattttagtg aattggacaa acgcgaagaa 1594201 gcggtctcaa atggccaagc agctcgatgc gttgtcaaat tcgttaaaac agtcgatttc 1594261 agaaatttat tatacgcctg taaaaatgga tgaaaaccgt attaagttgt acatgaacga 1594321 cggttatgtt gttacggcat ctattaaaac gtttgcagac cgaatgaaga cgtatccttc 1594381 tatcatctca cagctaagca gcaataaaaa aggaatcatt catttagaag ttgccaccta 1594441 ttttgaagag tttgggaaaa acgataaagc tgctaaaaag gaagatgaaa attgaggggc 1594501 aaatcagcag tccttctttc cttgattatg cttatcgcag gttttttgat ttcattttct 1594561 tttcaaatga caaaagaaaa caacaaaagc gcggctgaga cggaagagtg gaaaaaagaa 1594621 tatgcgctga gagatgaact gctgaaacaa gagaaagaaa ataagaagtt tgaaaaagaa 1594681 ttatatcaaa agcaaaacaa agtccgccag gcggaaaata agctgaagaa agagaagtcg 1594741 gaatactata atgtcctcga agatacagaa aaatacagga tgtatattgg ggaagtcggt 1594801 gtgcagggag aaggcgttga ggtgacattg gaagatgcgt catacatacc ggaaggggag 1594861 aatgtgaata gttacatcgt tcacgaaagc catatcttcc aagtagtaaa cgaactgtat 1594921 atctcaggag cggcagctgt cgccgttaat ggacagcgtt tgacgcatga ttcgtatatc 1594981 aaatgcaatg gtcctgtggt aacggtagac ggggtgcagc atcccgctcc gtttacggta 1595041 tccgctattg gagatccaga tgtcctgctg ccctcgttaa atatcgctgg aggcctaatt 1595101 gatcagctgt caatggatca tatttctgtg tcggcagaaa aagagaaaaa cgtacaaatg 1595161 aaaccgattc tgaaaacgaa ggaatgactg aaaaagcggg tgaaatagat tgaaaataaa 1595221 gcgttccttc ataagcatca gtgttcttat ggtcatcttc ggcctgatga tatctgttca 1595281 gtttaattcg ttaaagcacc ccaaagtccg ggatacaaga gatatgtggg atattaggga 1595341 agagctgaca tcagagcaga agaagcagga aaagctgctg gctgaaataa acaaatatga 1595401 caaattgctg aatagctatt cgcaaacgaa agaaatgaca aaagaaaccg cgctaaataa 1595461 taccttgcaa tccttaaaaa aaacagccgg catgaccgat ataacaggta gcggaattgt 1595521 cattacgatt tccccgcttt tttctgaaag cttaacagga gagccgatcg aaaatccgcc 1595581 tccggatttg ctgaaaaagc tgataaatga actcaactcc tacggtgcag agcatatctc 1595641 gattaatgag cgaagagttg tgaatcatac agtcatcaga gatataaacg gcactacaaa 1595701 aatagacgga tacgcccttg acgattatcc tttaacagta aaagtgcttg ccaaagatcc 1595761 ggacatgtta cacagcagag tgaaggggtc aggccttgag gatctttttg catctgaaaa 1595821 tttagcatta aaagccggta aatctgaaag caaactaaca ttaaaagcat atgacagacc 1595881 actggacgta caacagctga aactgcttaa agactgaaaa ggaggagaat tgtcatgtgg 1595941 ctgcccgtgt tgggactggt gctcggaata gcgattggac taatgacaaa cttaacgata 1596001 ccgagtgaat actcaaacta tttatcgctt gcggtgcttg ccgcacttga tacattaatc 1596061 ggcggaatca gggcgcattt acaaggtaca tatgatgaaa tggtatttgt ttccggtttc 1596121 ttttttaata ttatattggc aataagttta gcttttctgg gagtccatct tggtgtagac 1596181 ttgtatttag caggtatatt cgcatttgga gtcagattat ttcagaatat agccgttatc 1596241 agaagaaatc tactaacaaa gtggactctt tctaaaaaaa ataaaaaaaa tgtgatataa 1596301 aagaggatat acataggata taacgaatat tttcaataaa cataaaatgt gaaaagcaca 1596361 taaaaatatt ctgttgttat tttttgttac acacttgtaa agccacattc attgtattgt 1596421 tgttccgcaa ataatagaat agaaatgatc gaaatgtgag gaggtgccat agaatgaaca 1596481 acaatgaact ttacgtcagt cttgacatcg gtacgtccaa tacaaaagtg atcgtcggag 1596541 aaatgacaga tgattccctt aatattatcg gtgtgggaaa tgtaccgtct gaagggttga 1596601 aaaaaggctc aatcgttgat atagatgaga ccgttcattc tataagaaaa gcgtttgacc 1596661 aagctgaaag aatggtaggt tttccgctta gaaaagctat tgtcggcgtt aatggaaatt 1596721 atatcaatat tcaagataca aacggtgttg tagcagtttc cagtgaaaat aaagaaattc 1596781 aggttgaaga tgtacgccgt gtcatggagg cggcacaggt tgtttccgta ccgcatgaac 1596841 agctgattgt tgacgtcatt cctaaacagt ttatcgtaga tggaagagat gaaatcaccg 1596901 acccgaaaaa aatgctgggt gtgcgtttag aagtagaggg caccttgatc accggttcaa 1596961 aaacaatctt acataactta ctccgctgcg ttgaaagagc tggtattgaa ataactgata 1597021 tttgccttca gccgctggca gccggttctg ctgcattatc aaaggacgag aaaaaccttg 1597081 gtgtggctct cattgatata gggggagggt caacaaccat tgccgtattc cagaacggac 1597141 atctcacttc tacccgtgtc attcctctcg gaggcgaaaa tatcaccaaa gatatctcca 1597201 tcggattgag aacgtcaaca gaagaagcag aacgcgtgaa aaagcaactt ggacatgcct 1597261 actatgacga agcctcggaa gatgaaatat ttgaggtaac cgttataggc accaatcaaa 1597321 aacaaacatt tacacagcaa gaagcagcga atatcattga agcgagagta gaggaaattc 1597381 ttgaaattgt ttcagaagag cttcgcagta tgggaattac cgatctgccg ggaggcttcg 1597441 tgctgacagg aggacaagca gctatgccgg gtgtcatgtc tttggcacag gatgtgctgc 1597501 aaaacaatgt cagagtggca agcccgaatt atatcggtgt aagagatcct caatatatga 1597561 cgggagtggg cctgatccaa ttcgcctgcc ggaatgcaag aatccaaggc agaaaaatag 1597621 gctttaagat gcctgaagaa gcgatacagg aaatcgcagt ctcatcatct gaggaacaag 1597681 agcagcatca tcaccaaaat gaggtgcagc agcggccaaa aggaaaacaa aaaacacaag 1597741 ccgaacataa taaacagagc aaaatgaaaa aactattaag catgttttgg gaatagatag 1597801 atagtcattc ggcagattag gaggatttag catgttggag ttcgaaacaa acatagacgg 1597861 cttagcatca attaaagtaa tcggagtagg aggcggcggt aacaacgccg ttaaccgaat 1597921 gattgaaaat gaagtgcaag gagtagagta tatcgcggta aacacggacg ctcaagctct 1597981 taacctgtca aaagcagaag tgaaaatgca aatcggcgca aagctgacta gaggattggg 1598041 agcaggtgcg aatccggaag tcgggaaaaa agccgctgaa gaaagcaaag agcagattga 1598101 agaagcactt aaaggtgctg acatggtatt cgtgacagct ggtatgggcg gcggaacagg 1598161 aacaggtgcc gcaccggtta tcgcacaaat cgcgaaagac ttaggcgcat taacagtcgg 1598221 cgttgtgaca agaccgttta ccttcgaagg acgcaaaaga cagcttcagg ctgcaggcgg 1598281 aatctcggca atgaaagaag cggtggatac actgatcgtg atcccgaacg accgtatcct 1598341 tgaaattgtt gataaaaaca caccgatgct tgaagcattc cgcgaagcgg ataacgtact 1598401 tcgccaaggg gttcaaggta tttctgactt gattgctaca cctggtctta tcaaccttga 1598461 ctttgctgat gtgaaaacaa tcatgtcaaa caaaggatct gctttgatgg gtatcggtat 1598521 tgctactggg gaaaatcgcg cggcagaggc agcaaaaaaa gcaatttcca gcccgcttct 1598581 tgaagcggcc attgacggtg cgcaaggcgt cctcatgaac atcactggag gaacaaacct 1598641 cagcctatat gaggttcagg aagcagcaga cattgtcgct tcggcgtctg atcaagacgt 1598701 aaacatgatt ttcggttctg ttattaatga aaatctaaaa gatgagattg tggtgacagt 1598761 gattgcaacc ggctttatcg aacaagagaa ggacgtgacg aagcctcagc gtccaagctt 1598821 aaatcaaagc atcaaaacac acaatcaaag tgttccgaag cgtgagccaa aacgtgagga 1598881 acctcagcag cagaacacag taagccgtca tacttcacag ccggctgatg atacgcttga 1598941 catcccgaca ttcttaagaa accgtaataa acgcggctaa tgtaaaggac aaaatcgttt 1599001 tcgattttgt ccttttttgt ttttctcttc acactttcct tcttataaag tctttttccc 1599061 tattgcttcc ttcgcttagt aacaaaacag ataattagac ccatttattt ttgtgacatt 1599121 tttatcattt tcatatatat ggaaattgaa tgacatgaaa cgacaatatc tgtaattcag 1599181 attgtctaca gttaatatac agcgatgttc tgacaaacca ttcattatta aaaggaggga 1599241 cgacactttt tttaaaaagc atgttgaaaa agggggatga aaatgaggaa aaaaacgaaa 1599301 aacagactca tcagctctgt tttaagtaca gttgtcatca gttcactgct gtttccggga 1599361 gcagccgggg caagcagtaa agtcacctca ccttctgtta aaaaggagct tcaatctgcg 1599421 gaatccattc aaaacaagat ttcgagttca ttaaagaaaa gctttaaaaa gaaagaaaaa 1599481 acgacttttc tgattaaatt taaagatctg gctaacccag aaaaagcggc aaaagcggct 1599541 gttaaaaaag cgaaatcgaa gaagctgtct gccgctaaga cggaatatca aaagcgttct 1599601 gctgttgtgt catctttaaa agtcacagcc gatgaatccc agcaagatgt cctaaaatac 1599661 ttgaacaccc agaaagataa aggaaatgca gaccaaattc attcttatta tgtggtgaac 1599721 gggattgctg ttcatgcctc aaaagaggtt atggaaaaag tggtgcagtt tcccgaagtg 1599781 gaaaaggtgc ttcctaatga gaaacggcag ctttttaagt catcctcccc atttaatatg 1599841 aaaaaagcac agaaagctat taaagcaact gacggtgtgg aatggaatgt agaccaaatc 1599901 gatgccccaa aagcttgggc acttggatat gatggaactg gcacggttgt tgcgtccatt 1599961 gataccgggg tggaatggaa tcatccggca ttaaaagaga aatatcgcgg atataatccg 1600021 gaaaatccta atgagcctga aaatgaaatg aactggtatg atgccgtagc aggcgaggca 1600081 agcccttatg atgatttggc tcatggaacc cacgtgacag gcacgatggt gggctctgaa 1600141 cctgatggaa caaatcaaat cggtgtagca cctggcgcaa aatggattgc tgttaaagcg 1600201 ttctctgaag atggcggcac tgatgctgac attttggaag ctggtgaatg ggttttagca 1600261 ccaaaggacg cggaaggaaa tccccacccg gaaatggctc ctgatgttgt caataactca 1600321 tggggagggg gctctggact tgatgaatgg tacagagaca tggtcaatgc ctggcgtgcg 1600381 gccgatattt tccctgagtt ttcagcgggg aatacggatc tctttattcc cggcgggcct 1600441 ggttctatcg caaatccggc aaactatcca gaatcgtttg caactggagc gactgatatc 1600501 aataaaaagc tcgctgactt ttctcttcaa gggccatctc catatgatga aataaagccg 1600561 gaaatatctg caccgggcgt taatattcgt tcatccgttc ccggtcagac atatgaggat 1600621 ggttgggacg gcacatcaat ggcagggccg catgtatccg ctgttgctgc actgctgaaa 1600681 caggcgaatg cctcactttc tgttgatgag atggaggata tattaaccag cacggctgaa 1600741 ccgctcacgg attcaacatt tcctgattca ccgaataacg gatatggcca tggtctggtg 1600801 aatgcttttg atgctgtatc cgctgttaca gatggattag ggaaagcgga aggacaagtt 1600861 tctgtagagg gggatgacca agagcctcct gtctatcagc atgagaaagt aactgaagct 1600921 tatgaaggtg gcagcctacc actgactttg acagctgaag acaatgtgag tgtgacatct 1600981 gtaaagctgt cctacaagct tgatcaaggt gaatggacag aaataacggc taaacgaatc 1601041 agcggtgatc atctaaaagg aacgtatcag gcagagatcc cagatataaa aggaactaaa 1601101 ctaagctata agtggatgat tcacgatttt ggcggtcatg tcgtttcgtc tgacgtatac 1601161 gatgtaacag tgaaaccaag catcacggcg ggatataagc aggactttga aactgcaccc 1601221 ggcggctggg ttgcgagcgg aacaaataat aactgggaat ggggagttcc gtcaactggc 1601281 ccaaatacag cagcatccgg agaaaaagta tatggaacga atttgacagg aaattatgcc 1601341 aactcagcaa acatgaacct tgttatgcct cctattaaag cacctgattc aggaagtctg 1601401 ttccttcaat ttaaaagctg gcacaattta gaggatgatt ttgattacgg ctacgttttt 1601461 gttcttccgg aaggtgaaaa gaattgggag caggctggtg tctataacgg aaagacatca 1601521 agctggacgg acgaagaaat tgatttatcg gcttataaag gccaaaacat tcaagtgatg 1601581 tttaaccttc aatctgatga aagcattgca aaagagggct ggtatattga tgatgtagtg 1601641 ctttctgaca aatcagccgg aaaaacagtc aaaaagaata agctgggcgt cgaaaagccg 1601701 tctggaaagc aaaagaaaaa gccagtaaat ccgaaaaagg ctaagccatc tgcaaacaca 1601761 gcggtaaaac atcagaacaa ggctatacag cctcaagttt tgccgctcaa ggcacaagtc 1601821 agtgtagtgg aaacaggaaa atcaacatat tcagatcaat ccacagggca gtacacgctg 1601881 aagcacaaag cgggagacta tacgcttatg gcagaagcat atggttatca gtcgaaaaca 1601941 caaaaagtat ctttaaagac ggatcagacg acacaagcta attttacgtt agaagagatg 1602001 aagaagggca cattaaaagg cacggtcatc aataaaacga caggagagcc ggtaacaggc 1602061 gcttccgttt atgttgtaga ggatgctgcg gtggaaccgg ctatgacaaa cgacaaaggt 1602121 gaatatatgc tggaggccta tgaaggcgct tatacgatta aagtcgctgc accgggttat 1602181 tacagtgatg aattttccgt tgagttaaaa ggtgatgtta caaaagaaac tgcattgaag 1602241 cctttcgtcg gttatccggg tgaaattgca tatgatgacg gaacagcgga gaatgccaat 1602301 tcctattttg ctgccggtaa cggatgggcg gtaaaaatga cgctcgctga cggcaaggac 1602361 aaaggcatgc ttacaggagg gctgttcaga ttctgggata cagagttccc tgatccgggc 1602421 ggcacagagt ttaaggttga ggtatacgat gccacaggaa aagacggagc accgggcaag 1602481 aaaattgcag ggccatttaa cgcggaagct cttcgcaatg gcgagtggac taaggtagat 1602541 ctcagttcaa aagggattat ggtcgataaa gatttttatc tcgtatatat ccagtcgaaa 1602601 cctgatccgt attcacctgg attggcaatg gatgaaaccg gccagaattc cggccgcaac 1602661 tggcagtata tagatggaaa gtggcagcca ggtgacaaag cggatggcaa ctatatgatt 1602721 cgcgcattag ttgattatga agctgctgta cctgagatta cttcaccgac agacaaatca 1602781 tacacaaata aggatagcgt cactgtaaaa ggaaacgctt ctcctggcac aacggtacac 1602841 atttataatg gagagaaaga agcaggagaa acgaaagctg ctgcggatgg cacgttccat 1602901 gcaggcatca tactcaacaa gggtgaaaat gagctgacgg caactgcatc aactgacaac 1602961 ggaacaacag atgcctccag cccaatcacg gtcacgcttg atcaagaaaa gcctgaatta 1603021 acactggaca atccaaagga tggcgggaaa acaaataaag aaacgctgac tgtcaaaggg 1603081 gctgtatccg atgacaatct gaaagacgtc aaggtgaatg gcaaaaaagc aacagtagct 1603141 gatggttcat actcagcccg tattcttttg gaaaatggaa gaaatgaaat caaggtaatt 1603201 gctacagact tggcaggcaa caaaacgacg aaaaagacag tcattgatgt gaactttgac 1603261 aagcctgtca tttccggctt aattccggga gaggataaaa acttaaaagc cggtgaatct 1603321 gtgaaaatcg ctttctcaag cgctgaggat ttagatgcaa cgtttaccat tcgtatgccg 1603381 ctgaccaatg caagagcgag tgtgcaaaat gccaccgaac tcccgttaag agaaatctct 1603441 ccggggagat atgaaggcta ttggactgcc acttcttcta ttaaagcaaa aggagcaaaa 1603501 gtagaagtga tcgtccgaga tgattatgga aatgaaacaa gaaaaactgc gaatggaaaa 1603561 cttaatatga acacagaaaa ttaagtggaa aaaaagctgc cgtcattggc agcttttttt 1603621 atatcctctc attatacttc ctcgacaaat taagcagatt tccctgaaaa attgtatttt 1603681 cctctcaaca ttaattgaca gactttccca cagagcttgc tttatactta tgaagcaaga 1603741 aggggaacag cgtgaggcaa gaaagaaagg agtcagatgt gaaaatctat ttagatgtca 1603801 tttggctgtt aaacttttgt tttgatgcac ttttgctttt gctcacggca tttattttaa 1603861 aacggcatgt aaaaaaaaga agactggtag gcggagcgtt catcggttcc agtattgtcc 1603921 ttttgatgtt tactcctttt tcgccgattg ttgaacatcc ggctgggaag ctagcttttt 1603981 cagttgtgat tgtggtggtg acatttggct ttaaaagatt tcggtttttc tttcaaaatt 1604041 tgttttcctt ttattttgcc acttttttaa tggggggagg aattatcgga gcccattctt 1604101 tgctgcagtc aaattctatt gttcaaaacg gtgtcatgat taccaatcaa acagggtttg 1604161 gagacccgat cagctggttg tttattgttg gtggctttcc agcattatgg tttttttcta 1604221 aaagaagaat tgaagatatt gaaacaaaaa acattcaata tgaggaacga gtcagcgtgc 1604281 aggcagattt gggcagccaa acacttcatg tcagaggcct gattgattcc ggtaaccagc 1604341 tgtacgatcc tcttacaaaa acaccggtaa tgatcattta cattgataaa ctggagccga 1604401 ttttcggaac agccgaaacg atgatcattc gaaacacaga cccattggaa gccatcgaac 1604461 agctcgatga ttcctttcgc tttttagata aaatgaggtt gattccatac aggggagttg 1604521 gtcagcaaaa tcaattttta ttatgcgtta aaccggatca cgtaacgatt atgacaaaag 1604581 aagaaatgat ttctgcagat aaatgtttaa tcggtatcag cacaacaaag ctgtcggcag 1604641 atggagagtt tgacgcgatt attcatccga aaatgctttc gggcaaggct gtcaaacacg 1604701 tttcataatg ttcgcaaatg tccgttactt atcatactca aacggcgtga catttagaag 1604761 ggagaggaag atgaaaaaac tgaaattacg gttgacgcac ctctggtata agctgctgat 1604821 gaaacttggg ctgaaaagtg atgaagtcta ttacataggc gggagtgaag ccctgccgcc 1604881 tccattatct aaagatgagg agcaggtttt gttaatgaag ctcccaaacg gcgatcaggc 1604941 ggcgcgcgcc attctaattg aacgcaattt gcgtctggtc gtatatatcg cccgtaaatt 1605001 tgaaaatacg ggaattaata tagaggattt aatcagcatc ggtaccatcg gtctaatcaa 1605061 agctgttaat acatttaatc cagaaaagaa aatcaagctt gctacctatg cctcccggtg 1605121 tatagaaaat gaaatcctga tgtatttaag aagaaataac aaaatccgtt cagaggtttc 1605181 ctttgatgaa ccgcttaata ttgattggga cggcaatgag cttttgcttt ctgatgtgct 1605241 cggcactgac gatgacatca tcactaaaga catagaagct aacgtcgata aaaagctttt 1605301 gaaaaaagcg cttgaacagc ttaatgagag agaaaagcaa atcatggagc tgcggtttgg 1605361 gcttgtcggt gaagaagaaa aaacccaaaa ggatgtagcg gatatgatgg ggatttctca 1605421 gtcttatatt tcgcggcttg agaaaagaat tataaaaagg ttgagaaaag agttcaacaa 1605481 aatggtgtaa aaaattttat ggttagaacc ccttgatttt acagggattt cctgatttcg 1605541 acagtttttc ggtctgagtg cagtgcatat ttttcccacc caaggagata cttaacgttg 1605601 tacagcagct cctgtaggga gggaaaaaag tgtcgagaaa taaagtcgaa atctgcgggg 1605661 tggatacctc caaattacca gtactcaaga atgaagagat gagaaagctg tttaggcagc 1605721 tgcaggatga aggcgatgat tcagcaagag aaaagcttgt aaacgggaac ttgcgtcttg 1605781 tcttaagtgt cattcaacga tttaataaca gaggggagta tgttgatgac ttatttcaag 1605841 tcggctgcat cggactaatg aaatccattg ataattttga cctaagccac aatgttaagt 1605901 tttcaacata cgctgtacct atgattatcg gagagatccg caggtattta cgtgataata 1605961 acccgatccg tgtctcaaga tcactccggg acatcgctta caaggcgctt caggtaagag 1606021 agcggttaat cagtgagaca agcaaggagc cgactgcaga agacatcgca aaagttcttg 1606081 aagtaccgca tgaggaaatt gtatttgcgc ttgatgccat tcaggatccg gtttctctat 1606141 ttgaaccgat ctataacgac ggcggagacc cgatctatgt gatggaccaa atcagtgatg 1606201 agcgtaatac agattcacaa tggattgaag agctggcttt aaaagagggc atgagaaggc 1606261 tgaacgatag ggaaaaaatg attttgagaa agcgattctt ccaagggaaa acccaaatgg 1606321 aagtcgccga ggaaatcgga atttctcaag cgcaggtgtc cagacttgaa aaagcggcta 1606381 tcaaacaaat gaataaaaat attcatcaat aatgaaaagc ctttaaaacg atgttgtttt 1606441 aaaggctttt ctattgatta tggatggttt acgttttgga aaaagtaagg tatcctagtt 1606501 cgtacaaagt tttatgaaaa ttaaaacaat tataaaaggc aataaagagg aggaccacga 1606561 tgattttgca gcttgacaat gtctcactaa aacggaatgg gaaatggata ctgaaagata 1606621 ttcattggaa ggtggaagaa aaggaaaatt gggtgcttta cggcctaaat ggcgccggga 1606681 agacagcgct gttaaatatg ctttgctcat attattttcc aacatcaggc gagatgcagg 1606741 tgctcggcca tgaatttggc aaaacagagc ttggggaaaa gctcagacgt aaaattggcc 1606801 tcgtctcagc agctcttcag caaaaattgt atccggcaga ttcagctttt gaaattgctt 1606861 tgagcggagc ttacgcttcg attgggttat atgaaacgcc aagtaaggaa accagggaaa 1606921 aagcgatagg tttgttagag gacttgggag caattgaata tgccgatcgc cgctatgaaa 1606981 ccctttctca aggggaaaaa caaagagcat tgattgctag agcactaatg gccgatccgg 1607041 agctgctgat actggatgaa ccagtcacag gactggattt tattgcccgg gaaaagctgt 1607101 tagatacgat tacatacatt gcaaacaaag aaaatgcacc atctatcctt tatgtgactc 1607161 atcatgctga agaaattttg cctgtctttg ataaagccct tttattaaaa cagggagagg 1607221 tttttggatc cggagaaata aaggaaatgc ttactgatca aatactttcc gctttttttg 1607281 atacgccaat ccatgtatta tggaatcagg atcggccgtt tttaacaaga gctgagccga 1607341 taacgaatgc ctgacaaata tatatagatt catcctaggg gtgctttgcg aagctgagag 1607401 agactttgtc tcaacccttt tgacctgatc tggatcatgc cagcggaggg aagcggtgaa 1607461 aagcggagta catcggactc cgtttgtttt tattaagccg tttcatcaca tttgaaacgg 1607521 cttttttgat tttaaagaat aggagcggat ttacattgga tcaacaaata tactctttgc 1607581 aaaaaaaagt ggaagaacat aaggaggagc ttattcagct tgcgaaaacg ctgatttctt 1607641 atcaaacacc tgctccgcct gcaagaaata cagagggcat tcagtcttgg attgcgggat 1607701 atttaaatga attgggattc tcgatcgaca aatgggatgt gtaccctgga gatcccaatg 1607761 ttgtagggaa gctaaaagga acagattcag cagattatta tagcctgatt atcaatggcc 1607821 atgtagatgt ggcagaggta aaagaggatg aagaatggaa gcacgatccg tttcatccca 1607881 ttgaaaaaaa cggtctctta atcgggcgag gcgcttccga tatgaagggc ggaatggctt 1607941 gtgtgctgtt tgctgtcaaa ttaattcgtg aagcaagcat tgaacttcca ggtgatctga 1608001 ttctgcaatc ggttattggg gaggaagttg gagaggccgg cacacttgaa tgctgcaaga 1608061 ggggctacca cgctgatttt gcaattgtcg cggatacgag cgatatgcat attcaaggcc 1608121 aaggcggtgt cattacaggc tggatcgaaa tcaaaagcag tcaaacattt catgatggaa 1608181 cgagacggaa tatgattcat gcaggcggag gaacattcgg agcaagcgca attgaaaaaa 1608241 tggcaaaaat cattgcgggg ctcggtgaac ttgagcgcca ctggtctatt atgaaaagtt 1608301 atcccggttt taaaccaggc acaaatacga ttaacccggc agttatagaa ggcggcagac 1608361 atgcggcttt tatagcggac gaatgccggc tgtggatcac agtccatttt tatccgaatg 1608421 aaacccatga ccaagtggca gcggaaatag aagattacgt caatcggctg agtgacagtg 1608481 atatttggct tagggaaaac cgccctgtat tcaagtgggg aggctcatct atgatagaag 1608541 acaggggaga aatttttccg gcattggaag ttgaccctgg ccacccaggc gtcttagcgc 1608601 taactgcctc tcatcagaaa gtgaaacggg agtgtccaat tattgacgtt tctcaatcag 1608661 ttacagatgg cggatggctg tatgatgccg gtattccatg cgtaatatac ggtcctggag 1608721 atctgcacaa tgcacactct gtgaacgaga aggtatcgat tgagcagcta gtagagtata 1608781 caaaaattat actcgatttt atcatcagct ggtgcagccg gaaaaaagaa caatgacatg 1608841 aaaatttctt cttgctgaca aggttcagcc tgcccgttca tatacttgaa caaaaggacg 1608901 gaaaaaggac gtgatggaat gatcagcatt tcagaatttc aggtaaagga tgtcgtcaat 1608961 gtctcaaacg gaaaaaagct ggggagtatt ggtgatattg atatcaatgt gaccactgga 1609021 aaaattcagg cgatcatact cggaggaaat gggaaagttc tcggattttt tggaaaagaa 1609081 gaggaattgg tcattccatg gcgaaatata gtaaaaatcg gggaagatgt aatcttagtc 1609141 cgattaagtg aaccacatgc ataaacctgc ttgtctgccg cagattggca aatgccggaa 1609201 gtctcgattc ttccggcaca tttcatttag aaatatgcaa atcggcgctc aacgaatgca 1609261 gtaagatgtg gtaaaataag tgggaaattc cgctttttta aatgtttgtc gaaaggttgg 1609321 atcatcatga atacatatca cccattcagt cttaccacac cctcgacact catgatacaa 1609381 gactgggctc aaacgaatca aaacaacaaa gaggtcattg ccggatttac gacaaaaaac 1609441 ggcggtgtca gccaaaagcc ttttgaatcg ttaaatacag gattgcacgt tcatgacaaa 1609501 gatgcagatg tagttaaaaa tcgtgaatat attgccgata tgtttaatac tgatttgcag 1609561 tcttgggtat tcgctgatca gacacatgat aatcgcgttc agaaagtgac gcagagggat 1609621 aggggaaaag gcgcccgtga gtatcacacg gctctaaaag caacggacgg gatctataca 1609681 aatgaaaaaa atgtattttt agcattatgc tttgctgatt gtgtgcctct tttcttttat 1609741 gatccggtta agtcgcttgt cggagtcgcc catgccgggt ggaaaggcac cgtcaaacag 1609801 attggcagag aaatggtgaa gcaatggact gagaaggaag gttcaaatcc ctcagatatt 1609861 tacgctgtta ttggcccgtc tatcagcgga gcatgctata cggtagacga ccgcgtcatg 1609921 gatgctgtcc gcgcattgcc ggtttcagca gaccttgccg ccaatcagac ggcaaaggca 1609981 caatatcagc ttgatctgaa agagctgaac cgtcttatac tgatggacag cggtttggca 1610041 agtgaacaaa tttctgtcag cggtttatgc acggaaagcg agccgtctct tttctattct 1610101 catcgccgcg atcaggggaa aactggacgg atgatgtcct ttatcggaat gaaggaggca 1610161 taaaagatct tgcgtgttgt tgataattta cgacatataa acgaacgaat aaacgaagca 1610221 tgtaacagat cgggccgcag ctccgatgaa gttacggtta ttgcagtcac aaaatatgta 1610281 tcacctgaaa gagcacagga ggcagtagat gctggcatca cctgcctcgg agagaatcgg 1610341 gatgcggaac tgctccgcaa acaggaattg atgaaaggga atccggaatg gcattttatc 1610401 ggcagtctgc aatcaagaaa agcaaaatct gtcgtcaatt cggtttccta tatccattcc 1610461 ctagaccggc tctcattagc gaaagaaatt gaaaaacggg ctgaaggtac tgtacgatgc 1610521 tttgtgcagg tcaatacctc tcttgagcct tctaaacatg gcatgaaaaa agaagaagtc 1610581 attccattca tacaggagct ttccggtttc gaacatatcc ttgttgccgg gctgatgaca 1610641 atggctccgc tgactgatga tcaagatcag atcagaagct gtttcaggtc gctgagagaa 1610701 ctccgtgacc aggttcagaa gctgaaccag ccgaacgctc cgtgtactga actgtcgatg 1610761 ggcatgtcaa atgattttga aattgcaatt gaagaaggag ctacttatat tagaatcggc 1610821 tcatcgttag tcggaaatga aacagggggt gtacagcaat gagtatgaaa aataaactga 1610881 aaaacttttt ctcaatggaa gatgaagaat acgaatatga atatattgag acagagcggg 1610941 aatctcatga ggagcatgag caaaaagaaa agccggctta caacgggaat aaacctgcgg 1611001 gcaaacagaa tgtagtgagc ttgcaaagtg ttcagaaatc ctctaaagtg gtgttgagtg 1611061 agccgcgcgt ttatgcggag gcgcaggaaa tagccgacca tttgaagaac cggcgggcag 1611121 ttgtcgtcaa tcttcagcgg atacagcatg accaggcgaa gcggattgtt gactttttaa 1611181 gcggaaccgt ttatgccatt ggcggcgata ttcaaagaat cggctcagat attttcctct 1611241 gcacgcctga caacgtagat gtatcaggca caatttctga gctcatatct gaagacgaac 1611301 atcagaggtg gtaaagcgag atgatccttt atcaagtttt ttcggtttta agcttattaa 1611361 tcacaatata ctcatttgcc ctgatcatat atatttttat gtcatgggtg ccgagtacga 1611421 gggaaacagc agtcgggcgt tttttggctt cgatttgtga accatatctc gaaccattca 1611481 gaaaaatcat ccctccgatt gcaatgctgg atatttcacc aatcgtagca atacttgtgc 1611541 ttcggtttgc gacaaccggc ttgtggggac tttatcgcat gattgcgttt taatgtgaca 1611601 gtttgatagg ggcttggcag cagccaagcc tctttacata gaagggaaag acgatgagcg 1611661 atatatatca gcacttcaga aaagacgagc gggcctttat tgatcaagcg ctcgaatgga 1611721 aaagaattgt ccaggagcag taccggatga agctgaccga ctttttagat ccccgagagc 1611781 aggtcatcct ctctgctgtt acgggacagg cagatgtcgg gcttgccttt tccggcggct 1611841 atgacagagc ggagcggaaa cgggcgattc tgtttccaga gtacattact ccggaagaat 1611901 cagattttga actgcaggcg tttaacgtcc gttatgctga caagtttgtc tcagtagatc 1611961 atcgttctct gcttggtgca ttaatgggca taggattaaa gcggcaaaaa ttcggtgaca 1612021 tcgtgttttc tgagacagca gtgcaattga ttgtctcagc cgataccgct gattttgtgg 1612081 ctgcacagct gacccaagca ggcaaagcgg cggtcagcct agagaaaatc gacttgtcag 1612141 accttaacat tccagcagtt gatgtcgaaa taagagatga cacggtttct tctttaaggc 1612201 ttgacgccgt ctgcgcctct atgagcaggc aatcccgcca gaaatcacag acgcttgtga 1612261 aaaacggcct tgtgaaagtg aactggaagg tggttgaaga tccttcatac atagtcgcgg 1612321 aaggggacat gctgtctatc agaggttttg gccggtgcag cttaacaaaa atcgaaggaa 1612381 aaaccaaaaa agacaaatgg agagttacgt ttgaacgaca aaaatagtcg gtttttcagt 1612441 ttttttctcc atctgtgcga aatttgtttt ataatgtgaa ctagataacc gtactgaaat 1612501 gtaaaaatgg aggtggcatc atgccattaa cgccaaatga tattcacaac aagacgttta 1612561 caaaaagttt tcgcggatat gatgaagatg aagtaaatga attcctagcc caagtcagaa 1612621 aagattacga aattgttctc cgcaagaaaa ctgagcttga agcgaaagtc aatgagcttg 1612681 atgaaagaat cggacacttt gccaatattg aggagacatt gaataaatca attttagttg 1612741 ctcaagaagc ggctgaagac gtaaaacgca attctcaaaa agaagcaaag ctgatcgttc 1612801 gggaagcgga gaaaaacgct gatcgcatta tcaacgaatc gttatcaaaa tcaagaaaaa 1612861 ttgcaatgga aattgaagag ctgaaaaaac agtctaaagt gttcagaaca cgtttccaaa 1612921 tgctgattga agctcagctt gatcttctga aaaatgacga ttgggatcat ctccttgagt 1612981 atgaagtcga cgctgtattt gaggaaaagg aataaattct ctgattatct tgacattttc 1613041 ttagcttgtc gaatataata cgttcataaa ttcagatgaa aaaacggttg aaagggacag 1613101 tcatgtttcc ttcaggcctt catagcgacc cggagatggt gagagtccgg gatggccgga 1613161 atcatgtaga tcagcccttt agtttccttg ctgaactcac agtaggttag gacgttcatc 1613221 acgttacgat gctcaagagg aaaaagtgta tgcttgcttt ttctaaaagg gtggtaccgc 1613281 gagataagct ttctcgtccc ttatgggatg agagggcttt ttttattttc tgaaaaaatg 1613341 cagtggagga atgaaaatgg attttaaaga cacgctctta atgccgaaaa cagatttccc 1613401 gatgcgtgga aatttgccaa accgtgagcc tgacattcaa aaaaaatggg aggaagaaga 1613461 tatctaccgt cttgttcagg aacggacgaa agaccgcccg aaatttgttt tacatgacgg 1613521 acctccgtat gcaaacggcg acatccatat gggccatgca cttaacaaga ttttgaaaga 1613581 cttcattgtc cgctataaat caatgagcgg ctacaacgca ccgtatgtgc cgggctggga 1613641 tacacacgga ttgccaattg aaacagctct gacaaaaaac aaaaaggtca accgcaaaga 1613701 aatgtcagta gcggaattcc gcaaactatg cgaagagtac gcttggaagc aaatcgaggg 1613761 acagcgtgag caattcaaac gtcttggtgt ccgcggtgac tgggaaaacc catatgtgac 1613821 attaaaaccg gaatacgaag cgcagcaaat ccgcgtattt ggtgaaatgg caaaacgagg 1613881 ctacatttac aaaggcctta aaccggttaa ctggtcacct tcaagtgagt ctgctctggc 1613941 tgaagccgag atcgaatatc aagataaacg ttcagcatct atttacgtcg cttttggtgt 1614001 aaaagacgga aaaggcgttc ttgaaaacgg cgagcgcatc atcatttgga caacaacgcc 1614061 gtggacaatt ccggcgaacc tcggaatctc agtgcaccct gatcttgagt acagcgtgat 1614121 tgcagtaggt gaagaccgct ttgttgtagc aagtgcctta gtcgaaaatg ttgcatcggc 1614181 atgcggattt gatcagtatg aagtgacaag aacggtcaaa gggaaagacc ttgagaacat 1614241 tatcgctgaa cacccgctat atggcagaga ctctctcgtt atgcttggtg aacacgtaac 1614301 aactgatgcc ggaacaggct gtgttcatac agcgcctgga catggggaag atgactttat 1614361 catcggccaa aaatacggtt tagatgtgct ttgcccggtc gatgaaaaag gtgtaatgac 1614421 aagcgaagct cctggctttg aaggcatgtt ctatgatgat gcaaacaaag cgatcacaca 1614481 gcagcttgat gaaaaaggcg cacttgtgaa gcttgaattc attactcatt cttatccgca 1614541 tgattggaga acaaaaaaac caaccatttt cagagcaaca gcgcaatggt ttgcgtctat 1614601 taaagatttc agatcagacc tgctggatgc cattaaagaa accaaatggg ttcctgaatg 1614661 gggcgagcag cgtttgcaca acatggttcg ggaccgcgga gactggtgta tttccagaca 1614721 gcgtgcgtgg ggtgtgccga ttccggtatt ttacgctgaa aacggagaac cggttattac 1614781 agatgaaacc attgaacatg tttctgaatt gttcagacag catggatcaa acatttggtt 1614841 tgaaaaagaa gcaaaggatc ttcttccgga aggctttacg catcctggca gcccgaacgg 1614901 cacatttaca aaagaacagg atatcatgga tgtttggttt gattcaggct cttcacatca 1614961 agcagtgctt gaagaacgtg atgacctcgt tcgcccggct gatctatacc tagagggatc 1615021 tgaccaatat cgcggctggt ttaactcttc tctttctaca gcagtagccg taacagggaa 1615081 agcgccgtat aaaggtgtgc tcagccatgg gttcgcactg gatggagaag gacgtaagat 1615141 gagtaaatca atcggtaacg ttgttgttcc ggctaaagtc atgaaacagc ttggtgccga 1615201 catcttaaga ttatgggtat cttcagtgga ttatcaggcg gacgttcgcg tgtctgacgc 1615261 cattctgaag caggttgcgg aagtatatcg taaaatccgc aacacgttcc gtttccttca 1615321 cggcaacctt ttcgattttg atccaaaaac aaatgcggtg gctgtcgaag atcttcgcga 1615381 agtggatcag tatatgctga ttaagctgaa caagctgatt gataaagtga aaaaagcgta 1615441 tgatgagtac gaatttgcgg ttgtgtatca cagcattcat aatttctgca caatcgaatt 1615501 gagctcattc taccttgatt ttgcaaaaga tattgtctac atcgagcatg cggatcatcc 1615561 ggatagacgc agcatgcaga cagtattcta cgaaacgctt cttgcattag tgaagctttc 1615621 agcgcctatc cttccacata cggcagacga attgtggtct catttaacat ttgttgaaga 1615681 gcagagcgtt cagttgaccg atatgccgga aacaatcacg gttccaaaca gtgaagcgac 1615741 tgaagaaaaa tttgaccgct ttatggctct tcgtgatgac gtgttaaaag cattagaaac 1615801 tgcgcgaaat gaaaaaatta tcggtaaatc tttggaagca aacctgaaat tgtatccaaa 1615861 caaagaaaac aaggagctct tggcttccat aaaagaaaac ctttctcagc tgtttattgt 1615921 gtctgaactg acaatcagcg aagaaaatga agcgccgaac gatgcgcaaa gctttgcgac 1615981 gggtaaaatc gctgtcgaga aagcggaagg cgaaatgtgt gagagatctc gtgtgatttc 1616041 aaaagatgta ggggcaaatc cgaaatatcc tacactttca ttacgcaacg ctgaaatcgt 1616101 tgaaaaatac tatcaaaaat aatgcaaaag agcccggcgt aaaagccggg ctttttttgt 1616161 gccaagagtg acatccttta gaacgaaagg aaaaatctta tgggctttag atcatcattc 1616221 acaggcaaca ataaagatac tacgttaaga gcaggagttg tgaagaatga atgatcaact 1616281 gaccgcaatt tatacggaac ttcttctgat gaaagaagaa ttacagtcga gattatttga 1616341 gtattcttgc tttcaggttt ctacaagccc gcaagcagca atcaatcaaa aacaaaaagc 1616401 aactctgatc tatcatatta aagaagaact tcaagacgtt ctccttgcat tgtccaaaat 1616461 cgaaaacggc acattcggat actgtgaaga aactggggcc cccattcctc ttgcaaagct 1616521 ggcagtgctg ccgacggccc gaacagcaaa cgattttctt tattctgtcc aatttgagaa 1616581 aaaaacgctt ccgatatgga aatcaacgga tatcgaatat ggtcaggcac tgtatgaata 1616641 acagtgtctg tccggttaat atgcctgata tttctttact ccagtgcttt ttattgataa 1616701 aatgcataat ggattaaagt aaccgtaaac tggaggaacg tttgtgctgt attatatgat 1616761 tgcactactt attattgcag ccgatcaatt gacaaaatgg ctagttgtta agaacatgga 1616821 acttggccaa agcattccga tcattgatca ggtattctat atcacctccc atcgcaatac 1616881 gggtgctgca tgggggatat tagcgggtca aatgtggttt ttctacctca taacaaccgc 1616941 tgttattatt ggtattgttt attacataca gcgttataca aagggacaaa ggcttcttgg 1617001 cgttgccctc ggacttatgc ttggcggtgc catcggcaac tttatcgatc gggctgtcag 1617061 acaggaagtt gtggatttta tccatgttat tattgtcaat tacaattacc cgatatttaa 1617121 catcgcggac tcttcactat gtgtcggcgt aatgctttta tttatacaaa tgctgttgga 1617181 cagcgggaaa aagaaaaagg agcaatagca tgaatcaaat tgatataacc gcttcagaag 1617241 aacaaaaaag tgagcggatt gataaatttt tggcatcgac tgagaatgat tggtcaagaa 1617301 cccaggttca gcaatgggta aaagacggac aggttgtcgt gaacggaagc gcggtgaaag 1617361 cgaattataa aattcagccg ggtgatcagg tgaccgtcac tgtacctgaa ccggaagcgc 1617421 tcgacgtcct ggcagagcct atggatctgg atatttatta tgaggaccag gatgtgctgg 1617481 tcgtcaacaa acctcgcgga atggttgttc acccagcacc cgggcatctt acgggcacac 1617541 ttgtaaacgg tcttatggct cattgcacag acctttccgg aataaatggt gtgatgcgcc 1617601 cgggtattgt tcacagaatc gataaggaca cgtccggttt attaatggtg gcgaaaaatg 1617661 atatggcgca cgagtcactc gtaaaccaat tggtcaacaa aacggtcacg cggaaatata 1617721 cggcggttgt ccacgggctt atttctcatg atgacggcac aattgacgcg ccgatcggac 1617781 gggataaaaa agaccgtcaa agcatgactg tgacacgtga tggcaaaaac gctgtcactc 1617841 attttcatgt gcttgagcgt tttcaggatt ttacgttagt ggagtgccag cttgaaacag 1617901 ggagaaccca tcaaattcgt gttcatatga aatatatcgg attcccatta gcaggcgatc 1617961 cgaaatacgg cccaagaaaa acaatcgact ttaatggcca agcgcttcac gcgggagttt 1618021 taggttttga ccatccacga acaggagaat atgtcgaatt tgaagcgccg cttcccgagg 1618081 atatggcaga attaatcgaa aacctcagaa aaaacggttg acagagggtt tcttttctga 1618141 aataataaac gaagctgaat agattcttta aaacagtcca gagaggctga gaaggataac 1618201 ggatagacgg gatgcgtgta taggcgcgca ccttgtccta aaacccctct atgctctggc 1618261 aggaggggtt ttttcttcta tatgaactgt gaggtgtcac acattgaatc aaaaagctgt 1618321 cattctcgac gaacaggcaa ttagacgggc gctgaccagg attgctcacg aaatgatcga 1618381 acgcaataaa ggaatgaata actgcattct tgtcggcatt aagacaagag ggatttacct 1618441 ggcaaaacgc cttgcggaac gcattgaaca gattgaggga aatcctgtta cagtcggtga 1618501 aattgatatt actctttaca gagatgatct ttctaaaaaa acaagcaacg atgaaccgct 1618561 tgtaaaaggt gcagatattc cggtagatat tacagatcaa aaagtcattc tcgttgatga 1618621 tgttctgtat accggaagaa cagtcagagc aggaatggat gcgcttgttg atgtaggcag 1618681 accttcctcc attcagcttg cagtgcttgt ggacagagga caccgggagc tgccgatccg 1618741 agcggattat atcgggaaaa acatcccgac atcaaagtct gaaaaggtta tggtacagct 1618801 tgatgaggta gaccaaaacg atctcgtcgc catttatgaa aacgaataat agatcacctt 1618861 tttaagggca atccagagag gttgcaaaga ggtgcacaac aaaggcccaa aaagtattcg 1618921 gcaggtcttt gtatgcctct ttgcgtaaaa aagcaaagag gtttttttat acagtcattg 1618981 agtcatccta aaatgaaagt caacaatcag ggggaaatca tcatgagtaa gaaaaaagta 1619041 aatttagggg tcagggatgt cccgacacct ttctcttggg tttcattcag ccttcagcat 1619101 ttgtttgcca tgtttggctc aaccattttg gttccgaagc tcgtcggaat gagtcctgct 1619161 gtggcgttgg tgacaagcgg catcggaaca ctggcgtacc ttcttattac caaaggacaa 1619221 attccggcgt atctcggttc atccttcgcc tttatttctc cgatcattct ggtaaaagcg 1619281 accggcgggc cgggagcggc aatggttgga gcgtttcttg cagggctggt gtacgggctg 1619341 attgccttat tgattaggca gcttggaaca ggatggctga tgaagattct cccgcctgta 1619401 gtcgtagggc ctgttattat cgtcatcggg ctgggactgg caagcactgc agtaaacatg 1619461 gcgatgtatg ctgatccgaa cgcgagtgag ttggtctaca gcttaaagca ctttagtgtc 1619521 gcaggagtta cgctggcaat tacgattatt tgtgcgattt tcttacgagg gtttttaagc 1619581 ctgattccgg ttctgatcgg aatcatcggc ggatacctgt ttgcccttac tcaagggatt 1619641 gtcaacttcc agccggtgct tgacgcgaaa tggtttgcag tgcctgaatt tatcattccg 1619701 ttcaaagatt attcaccgtc agttacgctc ggcatcgcag ccgcaatggt tcctgtcgca 1619761 tttgtcacaa tgtcagagca tatcggccac caaatggtgc tgagcaaggt tgtcggacaa 1619821 gacttcatta aaaagccagg tcttcatcgc tctattatgg gtgacagtgt ggcgacaatc 1619881 ctcgcttccc tgatcggcgg ccctccgaca acgacttacg gagaaaacat tggcgtgctg 1619941 gccatcacaa gagtattcag cgtctttgtc atcgggggcg cggcagtgat tgccctttgc 1620001 ttcggcttta tcggcaaaat ttcagcgctg atcagttcag tgccgtcagc ggtcatggga 1620061 ggcgtctcct tcctgctgtt cggaatcatt gcttcaagcg gcctgagaat gctgattgac 1620121 aacaaaattg attatgaaaa caacagaaac ctcattatta catcagttat ccttgtcatc 1620181 ggtgtaggag gcgcttttat ccaagtgtct cagggcggat tccaagtgtc aggaatggcg 1620241 cttgccgcaa ttgtcggtgt catcttaaac ctgattcttc cgcaggcgaa ggaagagcag 1620301 gcagacacat ctgaacaaca tcatatttaa aaccttttaa tgaaagtcca gagaggcttg 1620361 gaagggttat gaagagaagg aagcttcaat gctgccctct atttaaccat accccgagtc 1620421 tatcttagac cggggttttt tttcagcctt aagttgaaaa gagaggggaa agaacatgaa 1620481 gcatttaacg acgatgagtg aacttagcac tgaggaaatc aaagatttgc ttcaaacagc 1620541 acaagagctc aaaagcggaa aaacagacaa tcagcttaca ggaaagtttg cagcaaacct 1620601 gtttttcgaa ccgagcacga gaacgcggtt cagctttgag gtcgcagaaa aaaagctggg 1620661 catgaatgtg cttaaccttg atggaacaag cacaagcgtg caaaaaggcg aaaccttata 1620721 tgacacgatc cggacgcttg aatcaatcgg tgtggacgtc tgcgtcatca ggcacagtga 1620781 ggatgagtat tatgaagagc ttgtcagcca ggtgaacatt ccgattctga atgcgggaga 1620841 cgggtgcggc cagcatccaa cacaatcact gcttgattta atgacgattt atgaagagtt 1620901 caatacgttt aaagggctta ccgtctccat tcacggcgac atcaagcata gcagagtggc 1620961 aaggtcaaat gcggaagtgt tgacaagatt gggtgcccgg gtcctatttt ccggcccttc 1621021 ggaatggcag gatgaagaaa atacattcgg cacgtatgtc tcaatggatg aagcagttga 1621081 gtcttccgat gttgtcatgc tgctgcgcat tcaaaatgaa cgacatcagt ccgctgtcag 1621141 tcaggaaggc tatttaaaca aatacggctt gaccgtagaa cgggctgagc gtatgaagcg 1621201 gcatgcgatc atcatgcatc ctgctccggt aaacagagga gtggagattg atgacagctt 1621261 agtagaaagc gaaaaatcaa gaatcttcaa gcaaatgaaa aatggcgtat ttatcagaat 1621321 ggcagtgata cagcgtgcct tacaaaccaa tgtgaaaaga ggagaagcag cgtatgtcat 1621381 atctcattaa aaacggctgg atactaaacg aaaatggtga aaaaacacaa gcggatatcc 1621441 gagtgactgg agaaaccatc accgcaatcg gcaagcttga tgcaacggat aatgaaacgg 1621501 taattgatgc aaaaggtttg ctcgtttcac ctgggtttgt tgatctccac gtgcatttca 1621561 gagagccggg cggagagaaa aaagaaacta ttgaaaccgg ggcaaaagca gcggcgcgcg 1621621 gcggctatac tacagtagca gcaatgccga atacgcggcc ggttcctgat acaaaggagc 1621681 agatggaatg ggtgcaaaac agaattaaag aaacatcatg cgtaagagtt cttccatatg 1621741 catccattac gatcagacaa atcggcgatg aaatgacaaa ctttgaagcg ttaaaagaag 1621801 ccggggcatt tgcttttaca gatgacggcg ttggtataca gacagcagga atgatgtatg 1621861 aagcgatgaa acgggcagcc gcaattgaca aagcgattgt tgcacattgc gaggacaact 1621921 ccttaattta cggagggagc gtacatgagg ggacattctc caaagcgaac gggctaaacg 1621981 gcattccttc tgtgtgtgaa tcggttcata ttgctcgcga tgtgctgctg gctgaggcgg 1622041 caaactgcca ttatcatgta tgccatatca gcacaaaaga atctgtcaga gttgtacgcg 1622101 atgcgaaaaa agcgggaatc agagtgacag cagaagtatc gccgcatcat ttgctgcttt 1622161 gtgatgagga catcccgggg ctggacacaa actataaaat gaatcctccg ctccgcagcc 1622221 cagaagacag agctgcttta attgaaggtc ttttagacgg aacaattgat tttatcgcaa 1622281 cagaccatgc accgcatacg gaagaagaga agaacacaga aatgaagctg gcgccattcg 1622341 gaattgtcgg cttagaaaca gcattcccgc ttctttacac acactttgtc aaaaatggca 1622401 gctggtcact gaagcagctg attgactaca tgacaatcaa gccatgcgaa gcgttcggtc 1622461 tcccatatgg aacattacaa acggggcaag ctgcggacat tacgttaatc gatttagaaa 1622521 aagaagcagt tatagacaaa gagacatttt tatcaaaagg aaaaaataca ccattcaacg 1622581 gcatcagttg caccggctgg ccggtcgcta caattgcggc agggaagctt gcttatgaag 1622641 aggggagact tgtcaaatga agagacgatt agtactggaa aacggagcgg tattcgaggg 1622701 agaagctttc ggaagcttag aacacaacat gggagaagtc gtttttaata ctgggatgac 1622761 aggctatcag gaaattttat ctgatccttc ttactgcgga cagatcgtaa cattaacata 1622821 cccgcttatc ggaaattacg gcattaaccg tgatgatttt gaatccatta ccccttttgt 1622881 caaagggctg atcatcaaag aattatgtga gctgccttcc aactggcgtt cagcatacac 1622941 cttagacgag tatttaaaaa tgaaaaacat tcccggactc cagggaattg atacaaggaa 1623001 gctgacaaga atgatccgca cggcaggcgc gctaaaagga acattcgctt catctgatga 1623061 agatatcgaa gcagtgctga aaagactgaa cgaaacggaa ttgccaagaa atcaagtatc 1623121 ccaagtatca gcaaaaacag catatccgag cccgggaaga ggcaaacgca ttgtcttggt 1623181 tgacttcggc atgaaacacg ggattctaag agagctgaac aaacggaaat gtgacgtcat 1623241 cgttgtgcct tacaacatta cagcggaaga ggtgcttcag ctgaaaccgg acggtatcat 1623301 gctttctaac ggacctggag acccgaagga tgtgcctgaa gcgattgaaa tgattaaagg 1623361 tgttcttgga aaagtgccat tattcggaat atgtctcggc caccaattat tcgcgctggc 1623421 gtgcggggcg aatactgaaa aaatgaaatt cggccacagg ggctcaaacc acccggtaaa 1623481 agagctggct acaggaaaag ttgccttaac atctcaaaac catggatata cagtttcgtc 1623541 tatcagtaaa acagaactgg aagtgacgca tatcgcaatt aacgacgata cgattgaagg 1623601 gctgaagcat aaaacattgc cggcatttac ggttcaatat catcccgaag cctcacctgg 1623661 tcctgaggat gccaaccatc tatttgacag attcatcgaa atgatcgaaa caacagagaa 1623721 agaaggggaa gcggtatgcc aaaacgcgta gacattaaca aaattttagt aatcggatct 1623781 ggaccgatca tcatcggcca agcagcagaa tttgactatg cgggaacaca agcctgtctt 1623841 gctttgaaag aagaaggcta tgaagtcatc cttgtcaact caaaccctgc aacgatcatg 1623901 acagatacag aaatggctga ccgggtttac atcgaaccgc tcacacctga attcctgaca 1623961 cgaatcatca gaaaagagcg cccggatgcc attcttccta cactcggagg ccaaaccggt 1624021 ttgaatcttg cggttgagct ttctgaaaga ggcgttttgg cagaatgcgg cgtcgaagtg 1624081 cttggcacga aactgtctgc gattcagcaa gctgaagacc gtgacttgtt cagaacatta 1624141 atgaatgaac tgaatgaacc ggtgcctgaa agtgagatta tccactccct tgaagaagca 1624201 gaaaaattcg tcagtcaaat tggattccct gtcattgtcc gcccggcata tacattaggc 1624261 ggaacaggcg gaggcatctg ctcgaatgaa acagagctaa aagaaatcgt tgagaacggc 1624321 ttgaaattaa gcccggtaca ccaatgtctg cttgaaaaaa gcatcgccgg ctataaagaa 1624381 atcgagtatg aagtcatgag agacagccag gatcacgcca ttgtcgtttg taacatggaa 1624441 aacattgatc cagttggaat ccatactgga gacagtattg ttgtcgcgcc gagccaaacg 1624501 ctcagcgatc gcgaatatca gctcttgcgg aatgtatcgt taaaactgat tcgcgcgctt 1624561 gggatcgaag gcggatgtaa tgtccagctc gccttagatc cagacagctt ccaatattac 1624621 attattgaag taaatccgcg tgtcagccgt tcatctgccc ttgcatcaaa agcaacgggg 1624681 tacccgattg caaagctcgc tgctaaaatt gcagtcggac tttcattaga tgaaatgatg 1624741 aacccggtga caggaaaaac atatgcagca tttgaacctg ctcttgacta tgtcgtatcc 1624801 aaaattccgc gctggccgtt tgataagttt gaatcagcaa acagaaagct tggcacgcaa 1624861 atgaaagcga caggtgaggt catggcaatc ggccgcacgc ttgaagagtc attgctgaag 1624921 gcagtgcgat cactggaagc ggatgtgtat catcttgaat tgaaggacgc cgctgacatt 1624981 tcagatgagc ttcttgaaaa gcgaattaaa aaggccggtg atgaacgctt attctactta 1625041 gctgaagcgt acagaagagg ctacacggta gaagacctcc atgaattttc cgctatcgat 1625101 gtcttcttct tgcataagct gttcggaatc gtacagtttg aaaaagaatt gaaggccaat 1625161 gcgggcgata cagatgtgct gagacgggca aaagaactcg gcttctctga tcagtacatc 1625221 agccgtgaat ggaaaatgaa agaatctgag ctttacagct tgagaaaaca agcggggatt 1625281 gcgccggtat tcaaaatggt agatacatgc gcggcggaat ttgagtcaga aacgccatac 1625341 ttctatagca catatgaaga agaaaatgaa tctgtcgtta cagataagaa aagtgtgatg 1625401 gtgcttggtt cgggtccgat tcgaatcggt cagggtgtcg agttcgacta tgcgacggtt 1625461 cactctgtat gggcaattaa acaagcaggc tatgaagcca ttattgtcaa caacaacccg 1625521 gaaaccgttt caacagactt cagcatctca gacaagctgt attttgaacc gcttacgatt 1625581 gaagatgtca tgcacatcat tgacctcgaa cagccaatgg gcgttgtcgt acaatttggc 1625641 ggacaaactg cgattaacct tgctgacgag ctttctgcac gcggagtgaa aatccttgga 1625701 acttcattag aagatttaga ccgtgccgaa gaccgggata aatttgaaca agcgcttgga 1625761 gaacttggtg ttcctcagcc gcttggcaaa acagcgacat cagttaatca ggcggtaagc 1625821 atcgcaagtg atatcggtta tccggtactg gtacgccctt cctatgtact tggcggccgg 1625881 gcgatggaga ttgtttacca tgaagaggaa ctgcttcatt acatgaaaaa tgcagtcaaa 1625941 atcaatccac agcaccctgt attaattgat agatacttga ccggaaaaga aattgaagtc 1626001 gatgcagtat ccgacggtga aacagtcgtc attccgggaa ttatggagca cattgaacgt 1626061 gcgggcgttc actccggaga ctcaatcgct gtttatccgc ctcagtctct cacagaggac 1626121 attaagaaaa aaattgaaca atacacgatc gcattggcta aagggctgaa tattgtcggt 1626181 ttgctcaata ttcaattcgt cttgtcgcaa ggcgaggtgt acgtgctaga agtgaatccg 1626241 agatcaagca gaaccgtacc gtttttaagc aaaattacgg gtatcccaat ggcgaatctc 1626301 gcaacaaaaa tcattcttgg tcaaaagctg gctgcgtttg gctatacaga gggccttcag 1626361 cctgaacagc aaggtgtatt tgtaaaagcg ccggtcttct cctttgccaa gctgagaaga 1626421 gtggatatta cgttagggcc tgaaatgaaa tcaacaggtg aagtcatggg gaaagattcg 1626481 acacttgaaa aggcgctcta caaagccttg atcgcttcag gtattcaaat cccgaactac 1626541 ggttccgtgc ttttaacagt agctgataag gacaaagaag aagggcttgc cattgctaag 1626601 cggttccacg cgatcggcta caacatttta gcgacggaag gaacggcagg ctacctgaaa 1626661 gaagcttcca ttccagcgaa ggtcgtcgga aaaatcggtc aggatggccc gaacttgctt 1626721 gatgtcatca gaaacggaga agcgcagttt gtcatcaata cgctgacaaa aggaaagcag 1626781 ccggcaagag acggttttag aatcagacgt gaatcagtag aaaatggtgt tgcctgccta 1626841 acatctttag atacggcaga ggcgatattg cgagtgctgg aaagcatgac attccgtgct 1626901 gatcaaatgc cggcagtcaa cacaaatcag gaggcggcag tcactatatg aaaaaagcgt 1626961 atttgacagt atgttctaac cagcaaattg cagaccgggt gtttcaaatg gttctgaaag 1627021 gggagcttgt ccaagggttt acaacccctg gacagttcct tcatcttaaa gtgagcgaag 1627081 cggttacgcc tcttttgaga aggccgatca gcatcgcaga cgtcaacttt gaaaaaaatg 1627141 aagtcaccat catttatcgg gtagatgggg aagggacaag actcttgtca ctgaagcagc 1627201 agggagaact tgtggatgtc ctcgggcctt tgggaaatgg ctttcctgtt aatgaagttc 1627261 aacccggaaa gacggctttg ctggtaggag gcggagtagg tgtgccgcct ctccaagagc 1627321 tgtcgaaacg cttgattgaa aaaggggtaa atgtcatcca cgttttagga ttccaatcgg 1627381 caaaggatgt tttttacgag gaagaatgcc ggcagtacgg agacacgtat gtggcaacag 1627441 ctgacggaag ctacggggaa accggatttg tcacagatgt gattaaacgg aaaaagctag 1627501 agtttgatat cctcctcagc tgcgggccga caccgatgct caaggcgtta aaacaggaat 1627561 atgcccataa agaagtatat ctgtccatgg aggaacgaat gggctgcgga atcggcgcat 1627621 gcttcgcgtg tgtgtgccat acaaacgaaa gtgagacatc ctatgtaaaa gtatgtctcg 1627681 acgggcctgt atttaaagct caggaggtgg cgctgtaatg ctagaggtga aattgccggg 1627741 acttgatttg aaaaacccaa tcattcctgc atcaggctgc ttcggttttg gaaaagaatt 1627801 ttcacgtttt tatgatttgt cttgtcttgg agctatcatg attaaggcta cgacaaagga 1627861 gccgcgcttt gggaatccga cgccgcgggt agctgagact ggtgctggaa tgctcaatgc 1627921 gatcggtctc caaaatccgg ggctggatag tgtgttgcat catgagctgc cgtggcttga 1627981 gcagtttgat acaccgatca ttgccaatgt cgcaggttct caagtcgatg attatgttga 1628041 agtcgcagaa catatcagca aagcgcctaa tgttcatgct cttgaattga atatttcctg 1628101 cccgaatgtg aaaacaggcg gaatcgcttt tggcacgaat cctgaaatgg ctgccgattt 1628161 gacaaaagcg gtgaaagagg tttcggatgt acccgtttat gtgaagctat ccccgaacgt 1628221 ggctaatatc acagaaattg cattagcgat cgaggaagcg ggagcggacg gtcttacgat 1628281 gatcaacaca ctaatcggca tgagactcga tttaaaaacc ggcaaaccga tattagcgaa 1628341 taaaacaggg ggactttcgg gccctgctgt gaagccggtt gccattcgca tggtgtatga 1628401 agtcagccag atggtcaaca tcccgattat cggaatggga ggcgtgcaaa cggctgaaga 1628461 tgccctggaa tttcttctcg cgggagcaag cgcagtcgct gtcggaacag caaactttgt 1628521 gaatcctttt gcatgtccag agattattga acagctccca tctgttttgc tccaatacgg 1628581 ctatcaatca attgaagaat gcatcggaag gagctggaat catgaaaaac aacctgccca 1628641 tcatcgcgct tgattttgcg tcagctgaag aaacacttgc gttcttagcg ccttttcagc 1628701 aagaaccgtt atttgtaaag gttgggatgg agctttttta tcaagaaggg ccatctatcg 1628761 tgaaacaact aaaagaaaga aactgcgagc tatttttaga tctaaagctt catgacatcc 1628821 cgactactgt aaacaaagcg atgaagcgcc ttgccagtct tggagtagac ctcgtcaatg 1628881 ttcatgctgc cgggggcaaa aaaatgatgc aggcagctct cgaaggctta gaagaaggta 1628941 cgccggctgg aaaaaaacgt ccgtcactta tcgcggtaac ccagctgaca agcacatctg 1629001 aacaaatcat gaaagatgaa ctgctgatcg aaaagtctct gattgatacg gttgtgcact 1629061 acagcaaaca ggcggaagaa agcggactgg atggagtggt ctgctctgtt catgaagcaa 1629121 aagccattta ccaagcggtg tcgccttcat ttctgactgt cactccgggg atcagaatgt 1629181 cagaggacgc tgcgaatgac caagttcgcg tagcgacgcc tgccattgca agagagaaag 1629241 gttcatcagc gattgtagta ggacgctcga ttacaaaagc ggaagacccg gtaaaagcct 1629301 ataaggctgt cagacttgaa tgggagggaa tcaaatcttg aaacaaatca tcgcaaaaca 1629361 tctattagac atccaagctg tatttttacg cccgaacgag ccgttcacat gggcaagcgg 1629421 cattttatca ccgatctact gtgacaaccg ccttacgcta tctttcccag aggtcagaaa 1629481 cgatgttgct tcaggtatca gcaagcttgt taaagagcat tttcctgaag ctgaaatgat 1629541 tgcgggaaca gcaactgccg gtattcctca tgctgctctt gcggcggacc atttgaatct 1629601 tccgatgtgt tatgtgagga gcaagccgaa ggcgcacgga aaaggcaatc agattgaggg 1629661 agctgtgcaa gaagggcaaa aaacagtcgt cattgaagac ttaatttcca caggaggcag 1629721 cgtgcttgaa gcttgtgcag ctttacaagc ggccggctgt gaagtgcttg gtgtcgtctc 1629781 aatctttacg tacggacttc ctaaagcgga ggaagccttc gcaaaggcag aactgccata 1629841 ctactcatta accgattatg atacgctcac agaggtcgcg cttgaaaacg gaaatattca 1629901 ttcagatgat ctaaaaaagc tgcaaacatg gaaacgaaat cccgagtcaa aagattggtt 1629961 taaaaaataa aaaataaatt caaatgatgt aaagaggctt caaagccttg ctgtacttga 1630021 aaacaggctg tgaggcctgt ttttttatta atcctataaa aaaagtcggg ttgacttatg 1630081 ttagaattgt gctaaaattt actacaaatc taaaaactta tcaagagcgg ctgagggact 1630141 ggacctatga agcccggcaa cctgcatagt ttgtaaggtg ctacttccag caaaatgaat 1630201 tccattttga aagataaggg ctgcatgctg ttcctgtctt tctttccgcc ggattgaaag 1630261 ttttttattt taagaggtaa aaaggctatc tgtatatcag cagccgcgaa tcacattaca 1630321 tgggaaaaga caaccggcag aaagctactg tttgtttgtc tccgaaagga ggaaagaaga 1630381 aatgttaacg tatgataatt gggaagaacc aacgattaca tttccggaag acgatcctta 1630441 taaaggagcg ctgtcagttt taaaatgggc atacggccat tacggcgatc agcttgttta 1630501 tgcctgcagt ttcggaattg agggaatcgt tctgattgac ttaatttata aagtgaaaaa 1630561 agacgcagag attgtgtttc ttgatacagg acttcatttt aaagaaacct atgaaacaat 1630621 tgaacgagtg aaagagcgtt atccgggtct taatatcatc ctgaaaaaac cagatctcac 1630681 ccttgaggaa caagccgaag aacatggtga caaactatgg gaaagagagc cgaatcagtg 1630741 ctgctatctt agaaaggtcg ttcctttaag agaggcgctt tcaggacatc cagcctggct 1630801 ttccggcctg cgccgtgatc aagggccaag ccgtgccaat acgaatttct taaacaaaga 1630861 tgaaaaattc aagtcagtaa aagtttgccc gcttatccat tggacttgga aagacatttg 1630921 gagatataca tcccggaatg aactggacta caatccgctt catgaccaag gctatccaag 1630981 tattggctgt gcgccttgca cttctcccgc ttttacagca gaagatttgc gctcaggcag 1631041 atggaatggt atggcgaaaa cagaatgcgg actgcatgaa taaggagctg caaaatggaa 1631101 ttagccgcta ttttatttag cttgtttttc gcgatgaata ttggtgcaag cggcgctgca 1631161 gcttcgatgg gggttgctta cggctccgga gccatcaaaa agaaaactta cgctttgatc 1631221 ctatgcgcag tcggtgtctt tgccggggcg gtcattggcg gaggcgaggt tgtaaaaaca 1631281 atcagctccg gcattattcc tgagcagacg attacactga cgattgtttg catcattatt 1631341 ggagctgctg ccctgtcgct ctttactgct aatctgctcg gcattccttt gtcgacaagt 1631401 gaagtaacag tcggcgcggt tgtcggcgtg ggagtggctt ataaagtatt gtttgtgaac 1631461 aatcttctga tcattgtgtc attttgggtt tttgtcccgc tgttcgcttt cggcttcacc 1631521 tatttcgtat ctaagctgtt tcgttatttt aagattgaag taaaatcttc taaaaagcaa 1631581 aaaatcctcg gcattgtttt gttagttgcc ggatttttcg aagcattctc tgccggcatg 1631641 aataacgtgg cgaatgctgt tggcccgtta gtagctgccg gtgtgcttga tgtcggaaaa 1631701 ggaaccttgt atggaggagc ttttgttgct cttggcgcac tgttattagg ccggcgagtg 1631761 ctagaaacaa acgggaagaa aattacgagg ttctccaaag gggaaggcat tctcttatcc 1631821 ggtacaggag cgggactggt gatcatcagt tctgtatttg ggatgccggt gcccttggcg 1631881 caagtcacgt catcgtctat tatcggaata ggcatggcga aaaacggtcc gaacgtgttc 1631941 cataaacaag ttgttcaaac gatgctgaag gtatggatcg tatcgccgtt tttatcttta 1632001 tcgatttctt atctgcttgt atccttgttt ttaaaagcag attattattc gatctttatc 1632061 atggtaagtg tgcttttagc ggcgggcggt gccatcagcc tgacaaaggc cattcgtaaa 1632121 gagagacgct cagtccacga acaaggcggg ggaatctgat cattaatctg agtaatttta 1632181 taagttaact aggaggagat ggatattatg agcttagcac cacacggagg aacattagta 1632241 aacagagtag atgaatcata tgatgtgagc ggcattcaaa aagaaattga acttgattta 1632301 atttctttcg cggatttgga attgatcggt atcggtgcat acagcccgat tgaaggtttc 1632361 tttaatgaaa aagattacgt atcagtggtc gaaaacatgc gtctttcttc cggcgttgtc 1632421 tggtctcttc caatcacgct tccggtcgat gcgcaaaaag cagcggaact gtcacttggt 1632481 gaaacggtaa agttaacgta tgaaggagaa acttacggcg ttatccaaat cgaagacctg 1632541 tacgtgcctg acaaacaaaa agaagctgtc aatgtgtaca aaacagatga acaggagcat 1632601 cctggtgtta aaaagctgtt cagccgcggc aatacatatg tcggcggacc gattacgttg 1632661 attaaaaaag cttcaaaaca gttccctgaa tttacatttg aaccgtcaga aacgagacgc 1632721 cagtttgcgg aaaaaggctg ggaaaccatt gtcggtttcc aaacaagaaa ccctgttcac 1632781 agagcgcatg aatacattca aaaaacggct cttgaaacag tagacggctt gttcttgaat 1632841 ccgttagtag gtgaaacaaa atctgatgac attccagctg atgtacggat ggaaagctac 1632901 caagtgcttc ttgatcatta ttacccgaaa gatcgtgttt tccttggtgt ctttttagcg 1632961 gcgatgcgtt atgcaggccc gagagaagca attttccacg cgcttgtcag aaagaactac 1633021 ggctgcacac atttcatcgt cggccgtgat catgcaggtg taggcgacta ttacggaaca 1633081 tacgaagcac aggaactgtt tgacacattt aaacctgaag aactcggaat tacaccgctg 1633141 aaatttgagc acagcttctt ctgtaaaaaa tgcggaaata tgggaacagc aaaaacttgc 1633201 cctcatggca gagagcatca cgtcatttta tcaggcacta aggtaagagg tatgctgaga 1633261 gacggtgtgc tgccgcctgc tgaattcagt cgaaaagaag tagtagaagt gttaatcaaa 1633321 gggatgaaga aaaaagaaga agtaggcgta tcttaaggag gactggcagt gacaaatcgc 1633381 gatattgtat ggcatgaagc ctctatcaca aaagaagagt atcagcaaaa aaacaagcat 1633441 aaaagctcca ttctctggct gacagggtta agcggctcag gcaaatcaac cattgccaac 1633501 gccgctgcga gagaattgtt tgagcaaggc taccaagtca ttgtgctgga cggggataat 1633561 atccgtcacg gcctaaatag ggatcttggt ttttctgatg aagaccgaaa agaaaacatc 1633621 cgccggatcg gagaggtggc gaagcttttt gttcagcagg gaaccattgt gattactgct 1633681 tttatctctc ctttccgcga ggacagacaa caggttcgcg agcttgtgga agcgggcgaa 1633741 tttaatgaag tctacattaa atgcgacctt gatatttgtg aacaaagaga tccgaaaggg 1633801 ctttacaaaa aagcaagaaa cggcgagatt ccgttcttta caggaattga ttctccttat 1633861 gaagaaccgg aagctccaga gctcgttctt gattcaggac agcatgaccg tgaagcgtgt 1633921 aaaaatcagc tgatcgagtt tgttaaacaa aaattgagct gaatatgatc tgctgcgttc 1633981 ttctcagatg ccggaatgca agcgagaaca tcatcacagc gaatcttctg gaagaactcg 1634041 aatagatcgg gggaaatacg atggggaaag tatatattgt aggagcgggt cccggtgacc 1634101 ctgatctgct gacaattaaa gcgctgaaag ccattgaaaa agctgatgtc atcttatatg 1634161 acagattagt aaataaagag attttacaat atgccaaaga gcaagcagac ctgatctact 1634221 gcgggaagct tccggatttt catacgatga agcaggaaac catcaatcga tttcttgtga 1634281 agtatgcgca aaaagggaaa atggttgtca gactgaaagg cggagaccct tttgtgttcg 1634341 ggagaggagg ggaagaagcg gaatgcctct ctgaaaatgg aattccgttt gaaatcattc 1634401 ccggcattac gtctggaatc gcggcagccg cttatgccgg gattcctgtt acccatcggg 1634461 atgcgggctc taacgtcgct tttgtaacgg gtcactataa aaaagaagaa gattttgagg 1634521 aaaagtggaa agcgctggct acaggaattg atacacttgt catctatatg ggtatcaaaa 1634581 acgtgcagca gattgaaaga aaactccttg aaaatggccg ggacggttct acgccagcag 1634641 cctttattca ttgggggaca acggacaagc aaaaatctgt tttttgtaca gttgacaccc 1634701 tttcagaaac ggtgataaaa gaaaacatta caaatccgag tttaattgtc attggaaatg 1634761 ttgtaaatta tcactataag ctggaatggt ttgaatctga actaaaaaaa caagatttaa 1634821 gcgaggcgtt gtaaaaatga aacaagcaat tttatatgtc ggccacggca gccgggtcaa 1634881 aaaagcgcag caagaagccg cagccttttt ggaaggatgc aaggcccaca tctctgtgcc 1634941 agtacaagaa atcagctttt tagagcttca ggagccgaca attgagacag gatttgaagc 1635001 atgtgtgaag caaggtgcca ctcatatcgc agtggtgcct ctgcttcttt taacagctgc 1635061 gcatgcaaaa catgatattc cggaagaaat tgtccgtgtt gcatctcgat atccatcagt 1635121 ccgtatttca tacggaaagc cgatcgggat tgacgaagaa gtagtcaagg ctgtatatca 1635181 ccgaatgaaa gacataggtg ttccgtatga aaatgccaga gtggtgctca tcggaagggg 1635241 aagttcagat ccagacgtca aaagagacgt aaccggaatt gctaatcttc ttcaggaaat 1635301 ggttccagtg aaggaagtca ttccgtgctt tttgacagca tgcggcccta attacaaaga 1635361 ggttttttca gaacttgaaa aagatgacgg cataacaacc tttatcgttc catatttgct 1635421 ttttacgggt atgctgatga atgaaatcga acgagaggtt cagaaattaa aagcccataa 1635481 tccgaacgtc tacctctctt cctatatcgg ttttcatcct catgtgaaaa acgcattttt 1635541 gaaccgtgtg agagaaactg cggcaaattc tgagggacaa tttgattttg atggaggttc 1635601 atatgcttcc gctgcacatt agcctggaaa agaagaaggt tgtgattgcg gggggcggaa 1635661 gcatcgctct cagaaggctg aaaacggtga tttctgaggg agctgatata acgcttgtca 1635721 gtccggatgt ggaaccggaa atcaagcaaa tggcagaaga gcggcgtatc aaatgggaaa 1635781 aacggacaat tgaaaaagaa gattatctca atgctttctt cattattgct gcgacggata 1635841 atgcggcagt gaacaaagaa attgcccaat ccgcttcgcc ttttcagctt gtcaattgtg 1635901 tcagtgacgc tgagcttggc aatgtatata tgccgaaaat cgtaaaaaga gggcatgtca 1635961 ctgtgtctgt ttctacaagc ggagccagtc caaagcacac gaaagagctt gctgaaaacg 1636021 tggataagct gattgacggc gattttgttg ctgaagtgaa caggctttat cagatgagaa 1636081 gaaagaaata agccagagca tacaaatgct ctggcttttc tttatgcggc tcagcttttt 1636141 ttgagcttga tgacagtatc agcatcaggc gtgacaaaga cggtatgctg gctgtcataa 1636201 gtgacgaaac cgggtttcgc gccgtttggt tttttgacat gcctgatttt tgtataatct 1636261 acaggcactg aacttgaatc tttagctttt gaaaaataag ctgcaattgt cgcggcttcc 1636321 atgattgttt gctcatcagg ttcgctgctt ctgatcacaa cgtgggagcc gggaatgtcc 1636381 ttcgtgtgaa gccagatatc gtctctggcc gccactcttg tcgttaaata ttcattttga 1636441 cgattgttct tacccactaa aattgtcagc cctgaggtgg attcatatgt ttctaacacc 1636501 ggattgtgcg gtttttgctt tttctggcct ttttgctgct tagggcgtaa atatttgccc 1636561 tcaacaagct cttccctgat ttcgctgata tcccggggag aagcggacga aagctgctga 1636621 atcagctgat caaaatattc gatctcttcc tgtgccagcc tgatttgctc ctcgacaact 1636681 gcgaccgaat ttttcgcttt ctgatacttc gtgaaatagg cctgtgcgtt ttcagaaggc 1636741 gttttgttcg ggtttaaagg aatcgtgatt gtcgggcttt cttcatcata ataattgatg 1636801 acctcagcct gtttatcacc ttttttcagc atatataaat tagcggttaa aagctctccg 1636861 taaagctgaa attccttcgc gttttccgaa tactccaggg ttttctctaa ttttttgatt 1636921 ttgttggcat tcttcttccg ttcgttcaca acaaaacgct caagatcctg agcctgttgc 1636981 ttaacccggt ctcgttcagc ttttccgaaa taaaaacggt cgagcagttc gcttaatgaa 1637041 tcaaaacggc gcgcttcgcc ctttagatga gtcagctcca gcagataaaa atattccttt 1637101 ccgtttacag tcgtaatgtt gggaatgaaa cggtgctctt tcacttcggc aaacagtgcc 1637161 agcaacgctt ttggcagtgt gactttgttg gcaaggcctg ctctgtgaac cgcttctttg 1637221 gcgaaaagcg gagacacgcc tgaaaagtgg tcgacaattt gtttatcaag ccttccttct 1637281 tgaaagctga ggtgacgcaa aatatcatct tctgacgcct caagaggcga tattttgtcc 1637341 tgagcaggcg gaagcttata atcttggccg ggcagtactg tacggtagct gttcattgac 1637401 ggtgataaat gcttaagtcc gtcgataatc acattttctg ctgcgtcagt caaaatgata 1637461 ttgctgtggc ggcccataat ttctacataa agctttcgta cggtttcatc gccaatttcg 1637521 tttcggcttt tgatatgaaa aatcataatg cggtctaagc ccgcttgttc aattttctca 1637581 atgaatccgc cttcgatatg ctttctcagc aacatgcaaa acattggcgg ttcgcttgga 1637641 ttttcataag cttgtgccgt gatatgcacc cgtgaatagc tcggatgtgc cgataataat 1637701 agtttttggt tttttccctt ggcacggatg tggaaaatca catcgtgctt atatggctga 1637761 tggatttttg taattcgtcc gcccattatt ttctcgttaa gttcgtgtgt cattccgtat 1637821 gtaaacatgc catcaaacga catatgcaat acaccctctc attcttcctg cattcgataa 1637881 ttatagcatg aaatgggacg agtcagaata agcatgctta tagagtgata tctctataag 1637941 agagcagggg agtggacgag cggaatgaag tttcatgaaa tgggacaaac agatttacta 1638001 gaggcaacca atacgtccat gaaacaagga ttaacagaaa aagaggtaaa aaaacgcctt 1638061 gacaagcatg gaccaaacga gctgcaagaa gggaaaaaaa cttcagcgct tctcttgttt 1638121 ttcgcgcagt tcaaagattt tatggtgctt gtgcttctgg cggcaacgtt aatctcagga 1638181 tttcttggtg aatatgtaga tgcggttgcg attattgcga ttgtgtttgt gaatggcata 1638241 ctcggtttct ttcaagaaag gcgtgctgag caatctcttc aggctttaaa agagctttca 1638301 acaccgcacg tcatggcact cagggaagga agctggacaa agattccttc taaggaactg 1638361 gtgccgggtg atattgtgaa atttacgagc ggggacagaa ttggcgcaga cgttcgaatt 1638421 gttgaagcga gaagccttga aatagaagaa tcagcgctaa ccggggaatc aatcccggtt 1638481 gtgaagcatg ctgataaatt gaaaaaaccg gatgtttcac tcggcgatat taccaatatg 1638541 gcatttatgg gtacgattgt gacccgcggc agcggtgtcg gggttgtcgt cgggacagga 1638601 atgaatacgg ctatggggaa aattgccgac atgcttgaat cggcagggac attgtcaacc 1638661 ccgctgcaaa gaagactgga gcagctcggg aagattttga ttgttgttgc attgcttctg 1638721 accgtacttg tcgttgctgt cggtgttatt cagggtcatg atctgtacag tatgttttta 1638781 gcaggtgtct cgttagcggt agccgctatt ccggaggggc tgccggcgat tgtgacagtg 1638841 gcgctttcgc ttggtgtaca gaggatgatt aaacaaaaat ccattgttag aaagcttcct 1638901 gctgttgaaa cgcttgggtg tgcgtctatc atttgctcag ataaaacagg gacaatgacc 1638961 caaaacaaaa tgacagtgac gcatgtctgg tccggaggga aaacatggag agtggcaggg 1639021 gccggctatg aaccgaaagg aagcttcaca ctaaacgaaa aagagatcag tgtcaatgaa 1639081 cataagccgc ttcagcagat gcttctgttc ggagcgcttt gtaacaactc caatattgag 1639141 aaaagagacg gcgaatatgt gcttgacgga gatccgacag agggagcgct gctcaccgcg 1639201 gcaagaaaag gcggtttttc aaaggagttt gttgaatcta attacagagt gattgaagaa 1639261 tttccgtttg attccgcacg gaaaatgatg actgtcatcg tagagaatca agacagaaag 1639321 cgctatatca ttacaaaagg tgcgccggat gtactcatgc agcgatcttc ccgtatttat 1639381 tatgatggct cagcggctct tttttcaaat gaaagaaaag cagaaacaga ggcggtatta 1639441 agacatttgg catcacaggc gctcagaacg atagcggtcg cctacaggcc gataaaagca 1639501 ggcgaaacac cgtcaatgga gcaggcggaa aaagatctga ccatgcttgg cctttcaggt 1639561 atcattgatc ccccgcggcc ggaagtcaga caggcgatta aagaatgccg tgaagcggga 1639621 attaagaccg tcatgattac aggtgatcat gtagaaaccg ctaaagcgat agcgaaagac 1639681 ttgcgcctcc ttccgaaaag cggcaaaatc atggacggca agatgctgaa tgaactttct 1639741 caagaagagc tttctcatgt ggtggaggat gtgtatgtat ttgcccgcgt ttcccctgaa 1639801 cataaactaa aaatcgtaaa agcctatcag gagaacgggc atattgtggc gatgacggga 1639861 gacggcgtca atgatgctcc tgccattaaa caggctgata tcggcgtctc tatgggcatt 1639921 accgggacag atgtggccaa agaagcatca tctcttgttc tcgtggatga taattttgcg 1639981 acgattaaat cagcgataaa agaaggcagg aacatctacg aaaatatcag gaagtttatc 1640041 agatacctgt tggcgtctaa cgtcggagaa atccttgtca tgctgtttgc gatgctgctt 1640101 gcccttcctt taccgctggt tccgattcag attttgtggg tcaacttggt gacggacgga 1640161 ttgccggcaa tggcgctcgg catggatcag ccggaaggag acgtcatgaa gcgcaagccc 1640221 cgtcatccga aagaaggggt atttgcccgc aagctaggat ggaaggtcgt ttccagagga 1640281 tttttaatcg gagttgccac tattttagcg tttatcattg tgtaccaccg caatccggaa 1640341 aacttggctt atgcccagac gatcgcgttt gccacattgg tgctcgctca gcttattcac 1640401 gtgtttgact gccgcagcga aacttctgtt ttctctagaa atccgtttca aaacctgtat 1640461 ttaatcggcg cggtattgtc atccattttg ctgatgcttg tagtaatcta ctatccgccg 1640521 cttcagccga ttttccatac tgtagccatc acgccggggg actggatgct cgtcatcggt 1640581 atgtccgcca tccctacttt tttgctggcg gggtcacttt taacaagaaa aaaataaatt 1640641 catatgatat aatcttaggg gtaatagcgt gtctattgcc cttttattat gagaacaggg 1640701 aagaattggg tgttttaaaa tgatacgaag tatgacaggc ttcggcagtg caagcaaaac 1640761 acaagacgat ctctctgtaa gcgttgaact taaatctgtg aactacagat ttaaagaagt 1640821 gaacgctcgt ttgccaaggc ctttgctata ttttgaagat aagctgaaac agaccattct 1640881 gcagcatatt cagcgcggaa gaattgagct tttcgtatcc gttgacagcg atatgcttgt 1640941 tgagaaaagg cttgaaattg attggccgct gctcgatgag tttgtcgcag ccgcgagaga 1641001 tatgaagaag cggtatcaat tgtctgcaga gcccgatgta atggatttct ttaagcttga 1641061 tcatgtcgtc caggttcatg aagaacagac gcaaaatgac aagctggagg cgttgatcat 1641121 cgatgctgca gaagaagcgg taaaaggtct ctgtgaaatg cgtgaaaaag aggggctgct 1641181 cttagcgaaa gactgcctga tgcatattga tcagcttgaa gagctggtga gagaaactga 1641241 attgctggct gcagatgtcg tatctcgtta ccgggaacgg ctgtatgcca gaatcaaaga 1641301 atggactgaa gacgtattag acgagagccg gcttgtaaca gaatgcgcta tttttgcaga 1641361 ccgctctgat atcactgaag agattacaag gctgaagagc cacttcgccc agtttcgtga 1641421 tatattagct agtggcggag ctgtcgggcg caaactcgac tttcttgttc aggagctcaa 1641481 tcgggaagca aatacgatcg gctcaaaagc aaatgatcat cagatcacaa agcttgtcgt 1641541 tgaaatgaaa agttctattg aaaaaataaa agaacaagtg caaaatatag aatagtgact 1641601 gtgcgtattg tttacagacg gtcttactag gctaaactag agacgtctat tttacagggg 1641661 gaacgtagaa gatgacgatt aaactgatta atatcggatt tggcaatatc atctccgcca 1641721 atcggatgat ttcgattgtc agcccggagt ctgcgccaat caaacggatg attcaggatg 1641781 caagagaccg cggaatgcta attgacgcta catacggacg aagaacccgt gcagttgtcg 1641841 tcatggatag tgatcacatt atcttatctg ccgtccagcc tgagacagtt gcacacagac 1641901 tttctgttaa agaagaaatt atggatgaag ggcaggggta attgccgcat gaaagaaaga 1641961 gggttattaa tcgttctctc aggtccctca ggagttggta aaggaacggt tcgacaagcg 1642021 atcttttcgc aggaagacac aaaatttgaa tattcgattt cagtaaccac aagaagtcca 1642081 agagagggcg aagtgaacgg agtcgattat tttttcaaaa caagagacga attcgagcaa 1642141 atgattgcgg acaacaagct gcttgaatgg gcagagtatg tcggcaatta ttacggcacg 1642201 ccagtcgatt atgttgaaca gacgcttcaa gatggaaaag acgtcttttt agaaattgaa 1642261 gttcaagggg ctcttcaagt gagaaatgct ttcccggaag gcctgtttat tttccttgcg 1642321 cctccaagcc tttctgaact gaaaaacaga atcgtgacac gaggaacaga aacagacgct 1642381 ctgattgaaa atcgaatgaa agccgcaaaa gctgagatcg aaatgatgga tgcttatgac 1642441 tatgtcgttg aaaacgataa tgtcgaaacg gcttgcgata aaatcaaagc aatcgttctt 1642501 gctgaacatt tgaagcgtga acgcgttgca ccaagatata agaaaatgct ggaggttgaa 1642561 taatcaatgt tagatccgtc aattgattct ttaatgaata aattagattc aaaatatacg 1642621 ctggtgactg tttctgcgag acgtgcccgt gaaatgcaaa tcaaaaaaga ccaaatgatt 1642681 gaacatacga tttcacacaa atatgtaggc aaagctttag aagaaattga tgcaggcctg 1642741 ctttcgtttg aaaaggaaga ccgcgaatag tagcacaagt agcaacctat atcatgtagg 1642801 ttgttatttt tttccgtgcg gttttgtaaa gtgcagaggg ggagaattca ttgcttaaca 1642861 atcgaaatgt gttactttgc gtgagtggag gcatcgctgt ttataaagcc tgtgcgttaa 1642921 cgagcaagct ggttcaggca ggagcaaatg tcaaagtgat tatgactgaa tccgcttgcc 1642981 gattcgtttc accgctgaca tttcaggcat tgagccgcca cgaagtctat acagatacat 1643041 ttaaagaaca aaatccaagc gtcatttctc atattgatgc cgcagactgg gccgacttga 1643101 ttatcgtagc gccggctacg gctaatgtga ttggaaaact ggcaaacggc atcgctgatg 1643161 atatgctgac gacaacattg ttggcagcaa cggctcccgt ttggatcgcg ccggcaatga 1643221 acgttcatat gtatgaccac ccggcagtca aacgaaacat ttctgttctt tatcaggacg 1643281 gttattgttt tattgagcca agtgagggct atttagcatg cggttacgta ggaaaaggca 1643341 gattggaaga gccggaaaac atcgtaaagc tggccgaaaa acattttgct gaagaaacat 1643401 ccgctccttt agaaggcaag catgtggtca ttacagccgg cccaacgcgg gaagcgattg 1643461 atcctgtccg gttttttacc aataaatcga cgggcaaaat gggctacgca ctggcggagg 1643521 ctgctgttca gctcggcgca cgggtaatct taatttctgg gcctgtttca cttgatcagc 1643581 ctaaaggcct tgctgagttt atccctgttc aatcggctgc ggatatgcgc gaagctgtgc 1643641 tctctgtgta tgacgcaagc gatatagtca ttaaaacagc tgcggtagcc gattttacgc 1643701 cgaaaacagt atttgaccat aaaatgaaaa aacaagacgg cggcatgacc ttagaactga 1643761 aaagaacagt cgatattttg aaagaattgg gcgagaaaaa gaaagagcag attttggtcg 1643821 gatttgccgc cgaaacacaa gacattgaac actatgcacg taaaaagctc gccgctaaaa 1643881 accttgattt gattgtggca aatgatgtga aagcaaatgg ggccggtttt ggtgctgata 1643941 cgaatatcgt gacaatcttt ttcaaagacg ggcataaacg cgaactcccg attatgtcta 1644001 agctcgatgt ttcttttgaa atccttcagg agatcgcagc cctctcaaaa caaaccggag 1644061 agcgctcatg aattttgcag aagtcatcgt tgatgtcagc accaaaaata tagacaggcc 1644121 ttttgattat aaaatcccag accatctgaa gggcatgatc aaaacgggga tgcgggtcat 1644181 tgttccgttt ggcccccgta agattcaagg gtttgtgaca gcagtcaaag aagcatctga 1644241 cctatcggga aaatctgtca aggaagtaga ggatttatta gatcttacac ctgttctgac 1644301 agaggagctt atgattctgt catcatggct gtcagacaaa acgctgtctt ttaaaataac 1644361 ggcgcttcaa gcaatgctgc ctgccgcctt aaaggcgaaa tatgaaaaag aattaaaaat 1644421 tgcacacgga gccgatcttc cgccgcaagt ggaacggctg ttttctgaaa caaagacgct 1644481 gctgtattca gatatacccg atcatgagac gctgaaactg attcaaaggc atgttcaaaa 1644541 aggggacatt gacgtgacgt ataaagtcgc gcaaaaaacc aataaaaaaa tggtcaggca 1644601 tattcaggca aatgcgagta aagaagagct tgctaagcag gctgagggat tgtcccgcca 1644661 agcagcaaaa cagcaggcga ttcttcactt tctcatctct gagccggaag gtgtgaaaat 1644721 tcctgcggcg gaattgtgca aaaaaacgga cacgagctct gcaaccatca aaacccttat 1644781 ccaaaaaggg cttttgaagg aaagctatga agaggtttac agagatccct atcaggacaa 1644841 aatgttcaaa aaaacagagc ccctgccgct gacagacgaa cagagggctg ccttcgagcc 1644901 catacgcgag acattggaca gcgatgagca taaagtgttc ctccttcacg gcgtgacagg 1644961 aagcggaaaa accgaaattt atctgcaatc aattgaaaaa gtactggcga aaggaaaaga 1645021 agccatcgtc ctcgtaccgg aaatatcgct gacgccgcaa atggtcaacc gcttcaaggg 1645081 ccgcttcggc tcccaggtgg cagtcatgca cagcggttta tccacaggag aaaaatatga 1645141 cgagtggcgt aaaatccacc ggaaggaagt acggcttgtc gtcggtgcca gatccgccat 1645201 ttttgctccg tttgaaaatc tcggaatgat aatcatcgat gaagagcacg agtcttccta 1645261 taaacaggaa gaaatgccgc gctatcatgc gaaagaggtg gcaatcaagc gggctgagca 1645321 tcacagctgc ccggttgtat tagggagtgc tacgccgaca ttagaatcat atgctagagc 1645381 gcaaaagggc gtatacgagc ttctttcact gaagcaccgt gttaaccatc gggtgatgcc 1645441 cgaggtttcg cttgtcgata tgagagagga gcttagaaac ggcaatcgct cgatgttttc 1645501 agttgaattg atggaaaagc ttgaagaaac gattgccaag ggtgagcagg cggtgctgtt 1645561 tttaaataag aggggctact cttcctttgt gatgtgcagg gattgcggct atgtcccgca 1645621 atgcccgcac tgcgacattt ccatgacgta tcatcgttac ggccaaaggc tgaaatgcca 1645681 ttattgcgga catgaagagc ctgttccgca cacttgtcct gaatgcgcaa gcgagcatat 1645741 ccgctttttc ggaacgggaa cacagcgagt ggaggaagag ctgacaaaag tgctgccaag 1645801 tgcgagagtg attcggatgg atgttgacac gacatcacgg aaaggcgccc atgaaaaatt 1645861 actgtcagct ttcggagaag gaaaagcgga tattcttctc ggaacgcaaa tgatcgcgaa 1645921 agggcttgat tttccgaatg tcacgcttgt cggagtgtta agtgctgata caacacttca 1645981 tattcctgat ttcagatcgg ctgaaaaaac atttcagctg ttaacgcaag tcagcggccg 1646041 ggcaggcagg catgaaaagc ccggccatgt catcattcaa acgtatacac cgtctcatta 1646101 cagtatccag ctgacgaaaa cacacgatta tgaaacgttc tatcagcatg aaatggcgca 1646161 caggagagag caatcctatc cgccatacta ctatttggct cttgtgactg tttctcatga 1646221 ggaagtggcg aaagcagcgg ttacagctga aaaaatcgct cattttttga aagcaaactg 1646281 cggagctgac acgaaaattc tcggaccaag cgcgtcgccg atagccagga tcaaagatag 1646341 atatcgctat caatgcgtga taaaatacaa acaggaaacc cagttatccg ctttattgaa 1646401 gaagatactg gaacattata aacgcgaaat tgaacaaaaa catgtaatga tttcaattga 1646461 tatgaatcct tatatgatga tgtaagatct cacgtcttgg agggtaacaa attggcagta 1646521 aaaaaggtcg tcacacatcc tgcggaggtt ttggaaacac ctgcggaaac cgtgactgtt 1646581 tttgataaaa agctaaaaaa actgcttgat gatatgtacg acaccatgct tgaaatggat 1646641 ggtgtcggac tggcagcgcc gcaaatcggc attttaaaaa gagcggccgt cgtagaaatc 1646701 ggggatgaca gagggagaat tgatctcgtt aatcctgaaa ttttagaaaa aagcggcgag 1646761 caaaccggaa ttgaaggatg cttgagcttt cctaacgtct atggtgatgt cacacgtgcc 1646821 gattatgtca aagtgcgtgc gtttaaccgt cagggaaaac cgttcattct ggaagcgcga 1646881 ggctttttag caagagccgt gcagcatgaa atggaccact tagacggtgt gctgtttaca 1646941 tctaaaataa gtaaatacta tacagaagat gaactagcgg atatggaagg atgatttgat 1647001 gacgagaatc gtatttatgg gaacgccgga tttttcagtt cctgttttaa gaaccctgat 1647061 agaggacgga tatgaagtag tgggggtcgt cacacagccg gaccgtccga agggcagaaa 1647121 aaaagtactg acacctcctc cggtaaagga agaggcattg cgccacggca tcccggttct 1647181 tcagccggaa aaagtcagat tgacagaaga aattgaaaaa gtgctggcat taaagcctga 1647241 cctgattgta acggcggcat tcggacaaat tttgcctaaa gagcttctcg acagtccaaa 1647301 atacggctgc attaacgttc acgcatccct tttgccggaa ctgcgcggcg gtgctccgat 1647361 ccattattcc attctgcagg gaaagaagaa aaccgggatt accattatgt atatggtaga 1647421 aaaattggat gcgggcgata tgatctcaaa agtggaagtg gacattgaag aaaccgacaa 1647481 tgtcggaaca ctgcacgata aattaagcgt tgctggcgcg aagctattgt ctgaaacggt 1647541 tccaaacgtt attgccggca gcatatcacc tgaaaagcag gatgaagaga aagcgacgta 1647601 cgcgcctaac attaaaagag agcaagagct gctcgactgg tccagaacgg gcgaagagct 1647661 ttacaaccag atccgcggct taaatccatg gcctgttgct tatacgactc taaacggaca 1647721 aaacttgaaa atatgggcgt cgaaaaaaat agcggcacca acaacagctg agcccggcac 1647781 agtcgttgca gttgaaaagg aaggaattat cgttgccaca ggtaacgaga cggctctgtt 1647841 attaaccgaa ctccagccgg caggcaaaaa acgaatgaaa ggcgaagact ttgtgcgagg 1647901 cgctcatgtt gaagccggtg atgtgttagg agtaaacaat gaaaaaaact agtgttcgtg 1647961 acatcgccct tgaggcgctg atcaaattag aacaaaacca ggcatacagc aacctgctgc 1648021 tgaaatcggt cattaaatca aatgaactga gtgatcagaa cagagggctt ttgactgaac 1648081 ttgtctatgg tacattacaa aataagatcg cgcttgatta tatgcttaaa ccgtttatca 1648141 ataagcctca aaaggtaaag ccgtgggtga ttcagcttct tcgcctatcc ttatatcaaa 1648201 tggagtattt ggagaagatt ccagacaggg cagccattca tgaagcggtt gagattgcta 1648261 aaatccgcgg acacaaaggc attgcttcat ttgtcaacgg cgtgctccgt tctattcagc 1648321 gcgaaggtgt tccatccttt gacgcgatcg aagatcctgt ccgccggctg gcgacagaaa 1648381 caagccatcc ggaatggctt gtgaaagagt gggcggatgc gtatggattt gaagctgcgg 1648441 aaaagatttg ccgcatccat ctcattccgc cgaaacagac gctgcgtgtc aatcaaatga 1648501 aagcagacag agctgagctg cttgaccaaa tggctgctga gggaatcgaa gttgaaaaag 1648561 gcgacctcgc tgaagatgct gtgaagctct taaagggaac aattgccgga actcatttct 1648621 tccaaaacgg cgaagtttct atccaggatg agagctccat gctcgtcgcc cgcgcccttg 1648681 atcctaagtc agatgaaaca gtgcttgacg cgtgtgcggc gcctggcgga aagtcggctc 1648741 atatcgcaga attaatgaag aacaagggga gcgttacgtc gcttgatctt cacaaacata 1648801 aagtgaagct gatcaaagaa gcggcagatc ggcttggcct gacaatcatt catgcggaaa 1648861 caatggatgc tagaaaagcg ggggaaacgt ttgaaaacga acagtttgac cgaatattgg 1648921 tcgatgcccc gtgctcaggt ttcggtgtta tcagaagaaa gccggacatg aaatacacga 1648981 aaaaacctga cgacagcgcc cgtctagctg aaatccagct gtcgatcttg agggaaatcg 1649041 caccattagt aaaaaaaggt ggcactcttg tctacagtac gtgtacaatg gaccggacag 1649101 aaaatgatga agtaatacat gcgtttatac aagaacatcc tgattttgaa cccgatttgt 1649161 ctcttgaaaa gcggctgcct gaaaaggtga gaccctttgt tcgggatgga aggcttcaaa 1649221 tccttcctca ttatttcgga acagatggtt tctttatttg cagcatgaga aagaagggat 1649281 aagcaatggc agaacttaat aaaacaaaag taagaaaaga attgcggaca gagcgtccgt 1649341 ctatttattc ttttgaatta gatgaaatca aacaatggct gacagacaat ggagagaaac 1649401 cgttccgtgc agcccagatc tttgaatggc tatatgaaaa acgcgtatct tcttttgaag 1649461 atatgacaaa cctctcaaag gatctgcgtg agaaattaaa cactcgcttt gtgttaacaa 1649521 cgctgaaaac ggctgttaaa caaacctctc aagacggtac gatgaagttt ttgtttgagc 1649581 ttcatgacgg ttataccatc gaaaccgttt taatgagaca cgagtatggc aattctgtat 1649641 gtgtaacgac acaagtcggc tgccgtattg gctgcacatt ctgcgcgtca acgcttggag 1649701 gcttaaaacg aaaccttgaa gcaggggaaa ttgtcgctca agtagtcaaa gtgcaaaaag 1649761 ctcttgatga aacggatgaa cgcgtcagct ctgtcgtgat catgggaatc ggcgaacctt 1649821 ttgataactt taacgaaatg ctcgctttct tgaaaatcat taaccatgac aagggcctga 1649881 atatcggtgc tcgccatatt acggtctcta cgagtggaat catcccgaaa atttacgaat 1649941 ttgctgatca gcaaatgcag attaactttg caatttctct gcacgcgccg aacacagaaa 1650001 tcagaagccg tttgatgccg attaacagag catataaact gcctgatcta atggaagccg 1650061 ttaaatatta tattaataaa acaggacgcc gtatcagctt tgaatacggg ctgttcggag 1650121 gcgtaaacga ccaggtggaa cacgccgaag agcttgccga cttgctggaa ggagtcaaat 1650181 gccacgtgaa cttgattccg gtaaactacg tgcctgaacg ggactatgtg cgcacaccgc 1650241 gtgatcagat ttttgctttt gaaaaaacgc tgaaatcccg cggagtaaat gtcacaatcc 1650301 gaagagagca aggacatgac attgacgcag cctgcggtca gcttcgcgcg aaggagcgtc 1650361 aagacgagac gaggtgatga gggttgttaa cagccttaaa aacagataca ggaaaaatcc 1650421 gccagcataa tgaagatgat gcggggatat tcaaggggaa agatgaattt atattagcgg 1650481 ttgtcgctga tggcatgggc ggccatcttg ctggagatgt tgcgagcaag atggctgtga 1650541 aagccatggg ggagaaatgg aatgaagcag agacgattcc aactgcgccc tcggaatgtg 1650601 aaaaatggct cattgaacag attctatcgg taaacagcaa aatatacgat cacgctcaag 1650661 cccacgaaga atgccaaggc atggggacga cgattgtatg tgcacttttt acggggaaaa 1650721 cggtttctgt tgcccatatc ggagacagca gatgctattt gcttcaggac gatgatttcg 1650781 ttcaagtgac agaagaccat tcgcttgtaa atgaactggt tcgcactgga gagatttcca 1650841 gagaagacgc tgaacatcat ccgcgaaaaa atgtgttgac gaaggcgctt ggaacagacc 1650901 agttagtcag tattgacacc cgttcctttg atatagaacc cggagacaaa ctgcttctat 1650961 gttctgacgg actgacaaat aaagtggaag gcactgagtt aaaagacatc ctgcaaagcg 1651021 attcagctcc tcaggaaaaa gtaaacctgc ttgtggacaa agccaatcag aatggcggag 1651081 aagacaacat tacagcagtt ttgcttgagc ttgctttaca agttgaagag ggtgaagatc 1651141 agtgctaatc ggcaagcgga tcagcgggcg ttaccaaatt ctccgcgtca taggcggcgg 1651201 gggaatggcc aacgtgtatt tagctgagga tatcattcta gaccgtgaag tcgcaattaa 1651261 aatcctgcgg tttgactatg caaatgacaa tgaatttatc agacgtttcc gcagagaagc 1651321 ccaatccgca tcaagcctcg atcacccgaa tattgtcagc atttatgatt tgggcgagga 1651381 agatgatatt tattatattg tcatggaata cgttgaaggc atgacgctta aagaatacat 1651441 aacagcaaat gggccgcttc accctaaaga agcgctgaac atcatggagc aaattgtctc 1651501 agccatcgct catgcccatc aaaaccagat tgttcacaga gacatcaagc cgcataacat 1651561 tttgattgat catatgggaa atatcaaagt aacggatttt ggaattgcga cggcactaag 1651621 ttcgaccaca atcacccata ccaattcagt tctgggctcg gtccattact tatcacctga 1651681 acaggcccgg ggcggcttag ccacaaaaaa atcggatatt tatgcgcttg gaatcgttct 1651741 atttgagctt ttaaccggcc gtattccgtt tgatggagag tcagcagtca gcatcgcctt 1651801 gaagcatctt caagcggaaa ctccttcggc aaaaaggtgg aatccatcgg tcccccaaag 1651861 cgttgaaaac atcatactca aggcaactgc caaagatcct tttcatcgct acgaaacggc 1651921 tgaagacatg gaagcagaca taaaaacagc ttttgatgcc gacagactca atgaaaagag 1651981 atttacgatt caagaagatg aagaaatgac aaaagcgata cctatcatta aagatgaaga 1652041 acttgctaaa gctgctggcg aaaaagaagc tgaagtgaca accgcacaag aaaacaaaac 1652101 aaagaagaac ggcaaaagaa aaaagtggcc gtgggttttg ctcacgatat gcctcgtttt 1652161 tatcacagct ggaattcttg ctgtcactgt ttttccgtcg cttttcatgc ctaaggatgt 1652221 caaaatacct gatgtctccg gaatggaata cgaaaaagcc gcagggctct tggaaaaaga 1652281 aggtttacag gttgattccg aggtgttgga aatctcagat gaaaaaattg aagagggcct 1652341 gatggtaaaa acggatccta aagcggatac cacagtcaaa gaaggcgcca cggtcaccct 1652401 ttataagagc accggaaaag caaaaacgga gatcggtgat gtgacaggcc aaacggtcga 1652461 ccaagcaaaa aaagcgttga aggaccaagg gtttaatcat gtaacagtaa atgaagtgaa 1652521 tgacgagaaa aatgcgggca ctgtcattga ccaaaatcct tcagcaggga ctgagctggt 1652581 cccgagtgaa gatcaagtca aacttacagt cagtatcgga cccgaagaca ttacgcttag 1652641 agacttgaaa acctacagta aagaagcagc gtctggatat ctggaagaca acggattgaa 1652701 gcttgtagaa aaagaagcat actcagatga tgttccagaa ggacaggttg tcaaacaaaa 1652761 accagcagca ggtacggcag taaagccggg aaacgaagtt gaagtgacat tctctctcgg 1652821 accagagaaa aaacctgcga aaacagtgaa agaaaaggtc aagatcccct acgaaccaga 1652881 aaatgaaggg gacgagcttc aagtgcaaat cgcggttgac gatgcggatc acagcatctc 1652941 tgacacttac gaagaattta agataaaaga gccgactgaa cgaacgatcg aactaaagat 1653001 tgaaccaggc caaaaagggt actatcaagt aatggtaaac aataaagttg tcagctacaa 1653061 aaccattgag tatccgaaag atgaataaca aggagggaaa atatgcctga gggcaaaatt 1653121 attaaggcgc taagcggctt ttactatgta ctggatgaat cagaggattc agataaagta 1653181 atacaatgca gaggaagagg cattttcaga aaaaacaaaa ttacccctct tgtcggtgat 1653241 tacgttgtgt atcaagctga aaatgacaaa gaaggatatc taatggaaat taaagaaaga 1653301 accaacgagc ttatcaggcc gccaatttgc aacgttgatc aagcggtcct tgttttctca 1653361 gcggttcagc cttctttcag cacggcattg ctcgaccgct tcctggttct cgttgaggcc 1653421 aatgatattc agccgattat atgcattact aaaatggatc tgattgaaga tcaagataca 1653481 gaagatacga tacaagccta tgcagaagac tatcggaata ttggttatga cgtatacctt 1653541 acctcctcta aggaccaaga tagtttagcg gacatcatcc cgcattttca ggataaaaca 1653601 acggtatttg ccggtcagtc cggtgttggg aaatcctcgc ttctcaacgc gatcagtccg 1653661 gagctcggat taagaacaaa cgagatttcc gagcatttgg gccgcgggaa acacacaacc 1653721 cgccacgtgg agctgattca cacgtccgga ggtttggttg cagatacacc gggattcagc 1653781 tcgcttgaat ttacagacat tgaggaagaa gagctgggct ataccttccc tgatatcaga 1653841 gaaaaaagct cttcatgcaa atttagaggc tgtttacatc tgaaagagcc gaaatgtgcg 1653901 gtgaaacaag ctgttgaaga cggggaatta aagcagtatc gctatgacca ttatgttgaa 1653961 tttatgacgg agattaaaga cagaaagccg aggtattagc ataatgataa aggttgcacc 1654021 atctattctt tccgctgatt ttgccgcttt aggcaatgag attaaagatg tagaaaaagg 1654081 cggagccgat tgtattcata ttgatgttat ggacggccat tttgtcccga atatcacaat 1654141 cggtccgctg attgtagaag cggtccggcc ggtaacggat ctgccgcttg atgtccattt 1654201 aatgatagaa gagccggatc gttatatccc ggcttttgcg aaagcaggcg cagatatcct 1654261 gtctgtgcat gctgaggcat gtccgcacct gcaccgtacc atccagctca ttaaagagca 1654321 aggagtgaag gccggagtag ttctaaaccc gcatacccct gtacaagtca tcgaacatgt 1654381 tttcgacgat cttgatcttg ttcttttaat gacggtgaac ccgggcttcg gcgggcagaa 1654441 atttattcat tcagtccttc ctaaaataaa agaggttaag cgaatggcgg atgaaaaagg 1654501 aaaaaaagat ctgttaattg aagtagacgg cggcgtcaac aaagaaaccg ctccgctcgt 1654561 cattgaagcg ggcgcaaatt tactcgttgc cggttcagct gtttatggcc agtctgaccg 1654621 caaaaaagca atttctgaaa tcagaggaag taaataagca gctttagaaa agagctgggc 1654681 atacaatagc ctaagctctt tttcctgtat gcagagaaag gaatcagaga tgaaaacaat 1654741 taatatcgtt gcgggaggcc cgaaaaatct cattcccgat ctaaccggct atacggatga 1654801 acacacgctt tggatcggtg ttgacaaagg caccgtcact ctcttagatg ccgggatcat 1654861 tcctgttgaa gccttcggag attttgacag cataacggag caagaacgcc ggcgaataga 1654921 aaaagccgct cccgcccttc atgtgtatca agcagaaaaa gatcaaacag atttagacct 1654981 cgcccttgat tgggcgctgg aaaagcagcc ggatattatt cagattttcg gcattacagg 1655041 cggcagagct gatcattttt taggaaacat tcagcttctg tataaaggtg taaaaacgaa 1655101 cataaaaatt aggctgatag acaaacaaaa tcatattcaa atgttccctc ctggtgaata 1655161 tgatattgag aaggatgaaa ataagcgata tatctccttc ataccgtttt ccgaagacat 1655221 acatgagctg accctgaccg gttttaaata tcctctaaat aattgtcata ttacgctcgg 1655281 ttcaacacta tgtattagta acgaactcat tcattcacga ggtacttttt cgtttgcaaa 1655341 aggcatatta ataatgataa gaagcacgga ttaagcatgt gctttcattc aattgctgaa 1655401 aacaatgaac aaggcggtta cgggacgtta taggagggga caaaaatgaa attttacacc 1655461 attaaattgc cgaagttttt aggaggaatt gtccgggcga tgctgggctc atttagaaaa 1655521 gattaatgcc caggggttca aagccctctt tcaccacata aaaacgcctg ccacatatcg 1655581 gggcaggcgt tcattttgtt atacacgctc aactttaccg gatttcaaag ctcgagcaga 1655641 tacatatact tttttaggtt ttccgttcac aaggatacga accttttgaa gattcgcgcc 1655701 ccaagtgcgc ttagaagcgt tcattgcgtg agaacggtta ttcccagctg ttgttttttt 1655761 acctgtgata acgcatttac gtgccatttg tttccctcct cacttgcaca aaacatctac 1655821 tttttaacat tcatataatc ttagatgctt tcgatatgga tactttaaat aatttaccac 1655881 agctaaaaaa cgtttgcaac tattgtttca tcatctttca agaaaattca cttgacatct 1655941 tgcggaaaca gcagcgctat agtatatgta gaggtacggc cagcgattat tgcctggtct 1656001 tttcataatg gaaaccatat agtagaatag ctgtaactct atgcattcga aggaggaact 1656061 agtgtgtcca ttgaattaag aacgaagtac ggacagattg atatatctaa tgaagtcatc 1656121 gcgatggttg caggaggcgc ggcggttgac tgttacggca ttgtcggcat ggcctctaaa 1656181 aaccagatta aagacggact gactgaaatc cttcggaaag agaatttcag caggggtgtc 1656241 caagttcgcc aagaaggaga acagatacat atcgacatgt atatcattgt cagctacggc 1656301 acgaaaattt ctgaagtggc acataatgtc caaacaaaag taaagtacac agtaaatcaa 1656361 accatcggac tggcagtgga ttctgtcaat atttatgtcc aaggcgtacg agtgacgaac 1656421 ccgtagttag gaggagtagg attgtctatc agaacattag acggcagaac ctttgccgag 1656481 atgattcttg cgggagcgca gaatctgtct caaaacgcca gtgcagttga tgcactgaac 1656541 gtgttcccgg tgccggacgg tgatacggga acaaatatga acctgtcgat gacttccgga 1656601 gcaagagaag ttgaacaaat ggatacggat gatatcggga aggtgggctc cgcgttatct 1656661 aaagggctgc tcatgggagc acgcggaaat tcaggagtta tcctatccca attgttccgc 1656721 ggatttagca aaaacattga aacgaaaaaa gaaattaatg cacttgagtt tgccgctgcg 1656781 ctgcaagcag gtgtagacat ggcgtataaa gctgtcatga aacctgtaga gggcaccatt 1656841 ttaacagttg caaaagacgc tgcaaaaaaa gcaatgatct tagcagaaaa agaaaccgat 1656901 atcactgcgc tgatgactgc agtgacagaa gaagcagagg cgtctttaaa ccgcacccct 1656961 gaattgctac ctgtcctaaa ggaagtagga gttgtcgata gcgggggcaa aggcctgctc 1657021 tgtgtgtatg aaggtttcct tgcttcatta aaaggtgaaa ctgtacctca gaaagcagtt 1657081 cttccgtcac ttgacgacat ggtcagcgca gagcatcaca agagcgcgca aagcatgatg 1657141 aataccgaag atattgaatt tggattctgt accgaagtga tggttaggct tgatcagaca 1657201 aaaagagagt tcgacgaagg cacgttcagg caagacctca gccagttcgg agattctctg 1657261 cttgtgattg cggatgaatc gctggcgaag gttcatattc atgctgaaga gccgggaaac 1657321 gtgttaaact acgcccagca ttacggtgaa ttgatcaaaa taaaaataga aaatatgaga 1657381 gaacagcata cctctatcat cagtcaagaa agcaaacctg cagacaacga aacaccgccg 1657441 gcaaaacagc cgtatggcat tgtgactgta gcgatgggag aaggaattgc agacctattt 1657501 aaaagcattg gcgcttctgt tgtgattgaa ggcggccaga ccatgaaccc aagcactgag 1657561 gatattgttg atgccgtgaa gtctgtaaat gcagatacgg tatttatcct gcctaacaac 1657621 tccaacatta tcatggctgc taaccaagcg gccagcgtag tggatgaaca ggtttttgtc 1657681 attcctgcta aaacggttcc gcaagggatg tcagctctgc tggcttttaa cccggatcaa 1657741 gaagctgaag cgaacgaggc caatatgcta agcgccattc agcaagtaaa aagcggacag 1657801 gtgacgttct cagtcagaga tactcatatt gacggtaaag acattaaaaa aggcgacttt 1657861 atgggcattc tgaatggaac gattatcggc acttctgaaa atcagctgtc agccgcgaaa 1657921 atgctgctgt cagaaatgat cggagaagat gatgaaatcg tgaccattct atatggtgag 1657981 gatgcgtctc aggaagaagc tgagcagctt gaagcgtttc tcagtgaaaa gtacgaggag 1658041 attgaggttg agatccacaa tgggaaacag cctctgtatt cgtatatagt ttcagcagaa 1658101 tagaagggca atttgccctt ctattcttat gtctgctttt aagtgcggca gcgctgtaac 1658161 gcgcccgctt gccattttat atctgatcaa ttagtctaga agcaaagcgc taataagctc 1658221 tggttcataa ggaggaatag catgaaatac agaagcgttt ttgatattat cggcccggtt 1658281 atgatcggtc cgtccagctc tcatacagcg ggagctgcta gaatcgggag agtggccaga 1658341 agtttatttg gcagagagcc tgagcgcatc attgtatctt tttacggctc gtttgcggaa 1658401 acgtataagg gccacggcac agatgtcgcg attatcggcg gattgcttga ttttgataca 1658461 ttcgatgaac ggattaaaac cgctatacaa attgcagaag ctaaaggaat tgatatagag 1658521 tttcgggtag aagacgcagt cccggtccac ccgaacacag caaaaatcac catttctgat 1658581 gaaaagggtg agctggaact gacgggtatt tcgattggcg gaggaaagat tgaaatcaca 1658641 gaattgaatg gttttgagct ccggctgtca ggaaatcatc cggccatatt agttgttcat 1658701 aatgacaagt ttggcacaat tgccggtgtt gccaatgttc tggcgaaatt ttcaatcaac 1658761 gtaggacata tggaagtagc ccggaaagat atcggccagc ttgcgctgat gacaatagag 1658821 gtcgatcaaa atattgacga ccacattctc gacgagctgt cgaagctgcc gaatattatt 1658881 caagtgacaa agattgctga ctagcgaaaa gggtcaggag gagccagtta tgtttcgtaa 1658941 tgtaaaagaa ttaattgaga ttactaaaga aaaacaaata ttgatctctg atgtgatgat 1659001 agctcaagag atggaagtaa cagaaaaaac aaaagaggac atttttcagc agatggatca 1659061 taacctgtct gttatggaag cggcggttca gaaaggactc gagggagtta cgagccaaac 1659121 gggcttaaca ggcggagatg ccgttaaatt gcaggcctat attcgatcag gaaaaagcct 1659181 gtctggcccg ctgattttag atgctgtatc gaaagccgtt gcaacaaatg aagtaaatgc 1659241 agccatggga accatctgtg cgacaccgac tgcaggttct gccggtgtgg tgcccggtac 1659301 gttatttgct gtaaaagaaa agctgaatcc aacaagagaa caaatgatcc gctttttgtt 1659361 tacagccggg gctttcggat ttgtcgtggc caataacgca agcatttccg gcgccgccgg 1659421 aggatgtcag gcagaggttg gatcagcttc aggcatggcg gctgcggcta ttgttgaaat 1659481 ggcaggagga acacccgaac aaagcgcgga agccatggcc attacattaa aaaatatgct 1659541 aggcctcgtg tgcgaccctg ttgcagggct tgttgaggtg ccttgcgtga aacggaatgc 1659601 gatgggcgcg tcaaatgcga tgattgctgc tgatatggca ttggcgggca ttacaagccg 1659661 tattccatgt gatgaggtta tcgatgccat gtataaaata ggccaaacga tgccaactgc 1659721 acttagagaa acaggccagg gcggtttagc ggcaacaccg acaggaagag aattagagaa 1659781 aaaaattttc ggaggagcgc taggttcacg tgaaacaaca tcagcaaact agtatagcta 1659841 acattaaggg tattgggccg gaaacagaaa aaacattgaa tgaactcggt atttatgaca 1659901 tttctgatct tctgaattat ttcccttatc gctatgatga ctacgagctg agggatttag 1659961 aagaagtaaa gcatgatgaa agagtcacag tcgaagggaa ggttcattca gagccttctc 1660021 ttacctatta cggaaaaaaa cgaaacaggc tgacattcag gcttctggtc ggccactatt 1660081 taatcacagc cgtatgtttt aaccggcctt atttgaagaa gaagctttcg ctcggctctg 1660141 tggtgacggt ttcaggtaaa tgggacaagc accgccaaac catctctgtt caggagttga 1660201 aaaacgggcc gcatcaagaa gacaaaagca ttgaaccagt gtattctgtg aaagaaaatg 1660261 ttaccgtcaa aatgatgagg cgctttattc agcaggcgct gacccaatat gcagactcac 1660321 ttcctgatcc tcttccggaa aagctaagaa aaagctataa actgcctgac tattatcaag 1660381 cgttaaaagc aatgcaccag cctgaaacaa gggaagcatt aaagcttgcc agacggcggt 1660441 ttgtttatga agaatttttg ttgtttcagt tgaaaatgca ggcgttccga aaggcggaaa 1660501 gagagcagac acaagggata cggcagcgtt tttcaaacga agaactcatg agatttatca 1660561 aaagcctccc gtttcccctc acaaacgccc agtcacgcgt tcttcgcgaa ataacagcag 1660621 acatgtcttc tccatacaga atgaaccgtc ttcttcaagg ggacgttgga tcaggaaaaa 1660681 cggcagtcgc cgccattgca ctgtatgccg cgatcctatc cggataccaa ggagcgctca 1660741 tggtgccgac agaaattctg gccgagcagc atgctgattc gctcgtttcg ctatttgaaa 1660801 aatgggacgt cagcgttgct cttttgacaa gctctgttaa aggaaagcgg cgaaaagaac 1660861 tgcttgagcg tcttgcggcg ggtgagattg atattcttgt aggaacccat gctttaatcc 1660921 aagacgaggt ggagtttaag gcgttgagtc tcgttattac tgatgaacag cacagatttg 1660981 gagttgagca gcgcaaaaag cttcggaaca aagggcagga tcccgatgtt ctctttatga 1661041 cagccactcc aatcccaaga acattagcga tcacagtatt cggtgaaatg gatgtatctg 1661101 tcattgatga gatgccggct ggacgaaagc gaattgaaac ctattgggta aaacatgaca 1661161 tgcttgatcg tattttggca tttgtcgaaa aagaattaaa gcaaggcagg caggcttata 1661221 tcatctgtcc gctgattgaa gaatcagata agcttgatgt gcaaaacgcc attgacgtgt 1661281 acaatatgct ttctgatatt tttcggggaa aatggaatgt cggccttatg catggaaagc 1661341 tgcattccga tgaaaaagat caggtcatga gagaattcag cgcaaatcac tgtcaaattc 1661401 tcgtatcaac cactgttgtg gaggttggcg taaatgttcc gaatgcaaca attatggtga 1661461 tttatgacgc cgaccgtttc ggactatcac agcttcacca gctgcgcggc cgtgttggac 1661521 ggggtgagca tcaatctttc tgtattctga tggctgatcc aaaatcagaa acagggaaag 1661581 aacggatgag gatcatgtcg gagaccaatg acggtttcga gctgtctgaa aaggatctgg 1661641 aactgagagg tcccggtgat ttcttcggga aaaaacaaag cggaatgccg gaatttaaag 1661701 tggcggacat ggttcatgat tacagagcgc ttgaaacggc aaggcaggat gctgcgaatc 1661761 ttgtggcttc tgacgcgttc tggaaggagc cggaatacgc tgtgttaaga gatgaattgc 1661821 tgaagagcgg agtaatggac ggggaaaaat taagctgagt atcagaagtt tttggtgttc 1661881 agccagaaac aatcgttgca ttccaatcta tgaaattata tactactatt agtacctagt 1661941 cttaattgtc cggatggtgt ttagatatga gaagaaataa gagagaacgc caggaattac 1662001 ttcagcagac gattcaagca acccccttta ttacagatga agaactagcg ggtaaattcg 1662061 gggtgagcat ccagacgata cgtttggacc gcttagagct ttccatacct gaactgagag 1662121 aaagaattaa gaacgtggca gagaaaacac ttgaggacga agtgaagtcc ctgtcacttg 1662181 atgaagttat cggagaaatt attgaccttg agctggatga tcaggcgata tccattttag 1662241 aaataaaaca ggagcacgtg ttcagccgga atcagattgc gagaggacac catttatttg 1662301 cacaggcgaa ttctttggcc gttgcagtca ttgatgacga gctggcgctg actgcaagtg 1662361 cagacatccg ctttacaaga caggtaaagc agggtgaacg tgtcgtagca aaagcgaaag 1662421 tgacggctgt cgaaaaagaa aaaggaagaa cggttgtcga agtgaacagc tacgttggcg 1662481 aagaaattgt tttttctgga cgctttgaca tgtatcgttc aaaacattca taaaggtgga 1662541 gcatgcatga gaatagctgt agatgcaatg ggaggagacc acgctcccaa agctgttatt 1662601 gacggagtta taaaaggtat agaggcattt gatgatctcc atatcacact tgtcggtgac 1662661 aaaacaacga tagaatcaca tttaacaact acatcagatc gcatcacggt gctgcacgca 1662721 gatgaagtga ttgagcctac ggatgaaccg gtccgtgccg tgcgaagaaa aaagaactca 1662781 tctatggttc ttatggcgca ggaggttgcg gaaaacagag ctgacgcctg catttcagcg 1662841 ggaaataccg gtgcattaat gacagccggt ctctttattg tcgggagaat taaaggaatt 1662901 gaccgtccgg cgcttgctcc gacacttccg actgtttcgg gagacggatt tcttctcctt 1662961 gatgtcggcg ccaatgtcga tgccaaaccg gagcacctcg ttcaatatgc catcatgggt 1663021 tctgtttatt ctcagcaagt gcgcggtgtc acttcaccga gagtcggact tttaaatgtc 1663081 ggaacagaag ataaaaaagg aaacgaactg acgaagcaga cgtttcaaat tttaaaagaa 1663141 acagcaaaca tcaattttat cggaaacgtg gaagcgcgag accttttaga tgatgtggcg 1663201 gatgttgtag taacagacgg ctttaccggg aatgttacac tcaaaacgct ggaaggctct 1663261 gcgttgtcaa tttttaaaat gatgagagac gtaatgacgt ctactttgac atccaagctt 1663321 gcagcagctg tgctgaaacc aaaattgaaa gaaatgaaaa tgaaaatgga gtattcgaat 1663381 tatggcggag caagtctttt tggcttaaaa gcgcctgtga tcaaggcgca cggctcttca 1663441 gattcaaatg ctgtattcca tgcgattcgg caagcaagag agatggtcag ccaaaatgtg 1663501 gctgcgctca ttcaggaaga agtgaaagaa gaaaaaacag atgagtagtc tggaggtttt 1663561 tacatcatga gtaagattgc atttttattc ccgggtcagg gatcacaatt tatcggcatg 1663621 ggaaaagagc tttatgagca ggtgcctgct gcaaagcgtc tgtttgatga agccgatgaa 1663681 acgttggaaa caaaactcag ctcgcttatt tttgaggggg atgctgaaga attaacactt 1663741 acatacaatg cgcagcctgc tttgcttacg acaagcatcg ctgttcttga gaaatttaaa 1663801 gaatctggca ttacacctga tttcacagca ggacacagcc ttggtgaata ttctgcactg 1663861 gttgcggctg gcgctctgtc tttcaaagat gctgtttata ctgtcagaaa gcgcggagag 1663921 tttatgaatg aagcggtgcc ggctggcgaa ggagcaatgg ctgcgattct cggcatggat 1663981 gctgaagcat taaagcaagt aaccgataaa gtcacagagg aaggcaacct tgtacagctt 1664041 gcgaatctca actgtcctgg ccaaatcgtc atttccggaa cagctaaagg ggttgagctt 1664101 gcatctgaac tggcaaaaga gaacggcgca aaacgcgcaa ttccgcttga agtaagcggt 1664161 ccgttccatt ctgaactgat gaaaccggct gctgaaaagc tgaaagaggt attggacgcc 1664221 tgtgacataa aagacgctga cgttccggtc atctcaaatg tttctgctga cgtgatgact 1664281 gaaaaagcag atatcaaaga aaaacttatt gagcagcttt actctccggt tcgttttgag 1664341 gaaagcatta acaagctgat cgcagagggt gttacgactt ttattgaaat cggtcccgga 1664401 aaagtgcttt caggccttgt gaaaaaagtg aatagacggt taaaaacaat tgctgtatca 1664461 gatccggaaa cgatcgagct ggcaattcaa acgcttaagg aggagaatga taatgcttaa 1664521 tgataaaacg gctattgtca ctggcgcatc ccgcggaatc ggccgctcaa tcgcccttga 1664581 tctggcaaaa agcggagcaa atgttgtcgt gaactactcc ggcaatgaag cgaaagcaaa 1664641 tgaagtggta gatgaaatca aatcaatggg cagaaaagca attgctgtaa aagcggatgt 1664701 atcaaatccc gaagatgtac aaaacatgat aaaagaaaca ttgtctgttt tttctacgat 1664761 tgacattctg gttaataatg cgggaattac aagagacaat ctcatcatga gaatgaaaga 1664821 agacgaatgg gatgacgtca ttaacattaa cctgaagggt gttttcaact gcacaaaagc 1664881 tgttacaaga caaatgatga aacagcgttc aggccgcatt attaacgtat cgtctatcgt 1664941 cggcgtcagc ggaaaccctg gacaagccaa ctacgtggct gcaaaagccg gcgtcatcgg 1665001 tttaaccaaa tcttctgcta aagagctcgc cagccgaaat attacggtaa acgcaatagc 1665061 gccaggattt atctcaactg atatgacaga taaacttgca aaagacgttc aagacgaaat 1665121 gctgaaacaa attccgctcg cgcgctttgg tgaacctagc gatgtcagca gtgttgtcac 1665181 gttcctagct tcagagggag ctcgttatat gacaggccaa acgcttcata ttgacggcgg 1665241 aatggtgatg taagtttttt ctcgaaaatt tcatcgtagt ttctctagtt ttttaaaaac 1665301 gaatccacta taatacttga ggggaggtga attgctatgg cagacacatt agagcgtgta 1665361 acgaaaatca tcgtagatcg ccttggcgtt gatgaagcag acgtcaaact tgaagcttct 1665421 ttcaaggaag acttaggtgc tgattcccta gatgtagttg agcttgttat ggaacttgaa 1665481 gacgagtttg atatggagat ttctgacgaa gatgctgaaa agattgcaac agtcggcgac 1665541 gctgtgaact acatacaaaa ccagcaataa gctgatgcta aaagtcccgc cgaaacgcgg 1665601 ggctttagcc ctttattcgt gcagttatta cagcatgccg cttttacgcg cgctgtatcc 1665661 ggtttagtca gagaagcgcg gtgaacctga tgtgcctatg gaggttacta tgtcaaaaca 1665721 ctcacattat aaagataaaa aaaagttcta taaaaaagta gaacaattta aagagtttca 1665781 agaacggatt tcggttcact ttcaaaatga aaagcttttg tatcaagcat ttacacattc 1665841 atcttatgtg aatgagcatc ggaaaaagcc gtatgaagat aatgaaaggc ttgaattttt 1665901 aggtgacgct gttttggaac tgacgatctc cagattctta tttgccaaat acccggctat 1665961 gagtgaagga gatttgacga aattgagagc cgcaattgtt tgcgaaccgt ctctcgtttc 1666021 attggctcac gagctgtcat tcggcgatct tgtcctgttg ggtaaaggcg aggaaatgac 1666081 aggcggaaga aagcgtcctg ctctattggc ggatgttttt gaggcattta tcggagcctt 1666141 gtaccttgac caaggattag agccggtcga aagtttctta aaagtttatg tgttccctaa 1666201 aattaacgat ggtgcttttt ctcatgtgat ggatttcaaa agccagctgc aggaatacgt 1666261 gcagcgggac ggcaaaggct ctctggagta taaaatctcc aacgaaaaag gacctgcgca 1666321 caaccgtgaa tttgaagcca tcgtatctct aaaaggtgaa ccactcggag tcggaaacgg 1666381 ccgttcaaag aaagaagccg aacagcacgc tgctcaggaa gctttagcta aattgcaaaa 1666441 acaccatacg aaacaataaa atccccctta tgactcaggg ggatttcagt atgtatgccg 1666501 tcttatttga ccaatgttta tgatagaatt gaaatactta ttacataagg aggatcgcta 1666561 tgttcctcaa acgtttagac gttataggat ttaaatcatt tgcagaacgg atttccgtag 1666621 acttcgttaa aggcgtgaca gcagttgtcg ggccgaacgg aagcggaaaa agcaacatca 1666681 cggatgccat tcgctgggtt ctcggcgaac aatcggcacg ctctcttcgc ggcggaaaaa 1666741 tggaagacat catttttgct gggagtgatt caagaaagcg attaaatcta gctgaagtta 1666801 cgcttactct tgataatgat gatcatttct tgccaattga cttccacgag gtgagtgtca 1666861 caagacgtgt gtacagatca ggtgagagtg agtttctgat taacaatcag ccatgccgct 1666921 tgaaagatat tattgattta tttatggact ctgggcttgg taaagaagca ttttctatta 1666981 tcagccaagg gaaagtggaa gagatcctga gcagcaaagc ggaggatcgc cgcagtatct 1667041 ttgaagaagc ggccggggtg cttaaatata aaacgagaaa gaaaaaagca gaaaataaac 1667101 tgtttgagac acaggacaat ctaaatcggg tagaagatat attacatgag cttgaaggac 1667161 aggttgaacc tcttaaaatt caagcttcaa tagcgaaaga ctaccttgag aaaaagaaag 1667221 agctggagca tgttgaaatt gcgctgactg cctatgatat cgaagagctg catggtaaat 1667281 ggtcgactct taaagagaaa gtgcagatgg caaaagaaga agagcttgct gaatcgtctg 1667341 ctatttctgc gaaagaagca aagattgagg atacaaggga caaaatacaa gcgcttgatg 1667401 agtcagtaga tgagctccag caagttttac tggtaactag tgaagagctg gaaaagcttg 1667461 aaggccgtaa agaagtcctg aaagaacgaa agaaaaacgc tgtgcaaaac caagaacagc 1667521 ttgaagaagc catcgttcag ttccagcaaa aagaaacggt tctgaaagaa gagctttcga 1667581 agcaggaagc tgtcttcgaa acgcttcagg ctgaggtgaa gcagttaagg gcgcaagtaa 1667641 aagaaaaaca gcaggctctc agtcttcaca atgaaaatgt cgaagagaaa atcgagcagc 1667701 tgaaaagtga ttattttgag ctgttaaaca gccaggcttc gatacgcaac gaactccagc 1667761 ttcttgatga ccagatgtcc caatccgctg tcacattgca gagacttgcg gacaacaatg 1667821 aaaagcacct gcaggaacgg catgatattt ctgcgcgtaa agccgcatgt gaaacggaat 1667881 ttgcccgaat tgagcaggag attcacagtc aagtcggtgc atatcgtgat atgcagacaa 1667941 aatatgagca gaaaaagcgc caatacgaaa aaaatgaatc cgctctgtat caggcatacc 1668001 aatacgttca gcaagcgaga tcaaaaaagg acatgcttga gacgatgcag ggagatttct 1668061 ccggctttta tcaaggtgtt aaagaagtgc tgaaagcgaa agagcgcctt ggcggaattc 1668121 gcggagcggt tcttgagctg atttctacag aacagaagta tgaaacggcc attgaaatag 1668181 cgctcggcgc ttctgctcaa cacgtcgtga ccgacgatga acaatctgcc cgcaaagcga 1668241 ttcaatattt aaagcagaat tccttcggcc gggcgacgtt tctgcctctt tctgttatta 1668301 gagaccgcca gcttcaaagc cgtgacgcgg aaacagccgc ccggcattca tcatttctcg 1668361 gggttgccag tgaacttgtc acatttgatc ctgcgtatcg aagcgtcatc cagaatcttc 1668421 ttggaaccgt tctgatcaca gaggacttaa agggtgcaaa cgagcttgcg aagcttctcg 1668481 ggcaccggta ccgcatcgta acccttgagg gagatgttgt gaaccccggt ggttcaatga 1668541 cgggcggcgc ggttaaaaag aaaaataact ccctccttgg aagaagccgg gagctagaag 1668601 atgtgacgaa acggctcgct gaaatggaag agaaaacggc actgcttgaa caagaggtca 1668661 aaacccttaa gcactccatt caggatatgg agaaaaaact ggctgactta agagaaaccg 1668721 gggaaggctt aaggttaaag cagcaggatg tgaaaggcca gctgtacgaa cttcaagttg 1668781 ccgagaaaaa tatcaatacc catttagagc tctatgatca agaaaaatct gctctgtcag 1668841 aaagcgatga agagagaaaa gtgcgcaaac gcaagcttga agaagagctc tctgccgtat 1668901 ctgaaaagat gaaacagctt gaagaggaca tagacagact gacaaaacaa aaacaaacgc 1668961 aatcctcaac gaaagagtct ctctccaacg agctgactga gctgaagatc gcagcggcca 1669021 aaaaagagca ggcttgcaag ggggaagagg acaaccttgc cagattaaag aaagagctca 1669081 ctgaaacaga gcttgcgtta aaagaagcaa aagaagactt aagcttctta acgtcagaga 1669141 tgtcatctag caccagcggc gaagaaaagc tggaagaagc agcaaaacat aaattgaatg 1669201 acaaaacgaa aacgatcgaa ctgattgcat taaggcgcga tcagcgcatc aagcttcagc 1669261 atgggcttga tacgtatgag cgtgagctga aagaaatgaa acgcctgtat aaacaaaaaa 1669321 caacgctctt aaaagacgaa gaagtcaaac ttggacgaat ggaagtcgag cttgataatt 1669381 tactccaata cttacgggag gaatacagct tgtcctttga gggggcaaaa gagaaatatc 1669441 agcttgaaac tgatccagag gaagccagaa agcgcgtgaa gctgattaaa ctcgcaattg 1669501 aagagctggg taccgtgaac ctcggaagca tagatgagtt tgagagggtc aacgaacggt 1669561 acaagtttct gtcggaacaa aaagaagatt taacagaagc gaaaaatacc ttgttccaag 1669621 tgattgaaga aatggatgaa gaaatgacga agcgctttaa cgacacattc gtccaaatcc 1669681 gctcacactt tgatcaagtt ttccgctcct tattcggagg agggcgagct gaactgaggc 1669741 tcaccgatcc taacgatctg cttcattcag gagtcgagat tatcgctcag ccgccgggga 1669801 aaaagctgca aaacttaaac ctcctgtcag gcggagagcg tgcgcttact gctatagcgc 1669861 tcttattctc aatcctaaag gttcgtccag tgccgttttg cgtccttgac gaagtagagg 1669921 ctgcgctcga cgaagcgaat gtgttccgat ttgcgcagta tttaaaaaaa tacagcagcg 1669981 atactcagtt tattgtgatt acccacagaa aaggaacgat ggaggaagcg gatgtgcttt 1670041 atggcgtaac catgcaggaa tccggtgttt ccaaggtaat ttcagttaag ctggaagaaa 1670101 caaaagaatt cgttcagtaa cgaggaaaga ggttaaaaga tgagcttttt taaaaaatta 1670161 aaagagaaaa tcacaaaaca gacagattcc gtatctgaaa agtttaagga tggccttgaa 1670221 aaaacaagaa actcctttca aaacaaagtg aatgatcttg tatcccgtta ccgtaaagtg 1670281 gatgaggatt tcttcgaaga gcttgaagag gttcttatca gcgcggatgt cggttttaca 1670341 accgttatgg aattaataga tgagctgaaa aaagaagtca aacgcagaaa tattcaagat 1670401 ccaaaggaag tccagtcagt gatttctgag aaactggtcg agatttataa cagcggagat 1670461 gagcaaattt cagaactgaa catccaggat gggcgtttaa acgtaatcct tctggtaggt 1670521 gtaaacggcg tcgggaaaac aacaacgatc ggaaagcttg ctcataaaat gaaacaagaa 1670581 ggaaaatctg ttgtacttgc cgccggagac acttttagag cgggagccat tgaacagctg 1670641 gaagtatggg gagagcgtac aggagtgcct gtcattaagc agacggcagg aagcgatccg 1670701 gcggctgtca tctacgatgc tgttcatgct gcgaaagcaa gaaatgccga tgtattaatt 1670761 tgtgatacgg cagggcgtct ccaaaacaaa gtaaatctca tgaaagagct tgaaaaagta 1670821 aaacgtgtta tcgaaagaga agttcctgaa gctccgcatg aggtgctgct tgcccttgat 1670881 gccacgaccg gccaaaatgc aatggctcag gcaaaagaat tctctaaagc aacaaatgtt 1670941 accggcattg ctttaacgaa gcttgacggt acggcaaaag gcggtatcgt ccttgcgatt 1671001 cgcaacgagc ttcacatccc ggttaaacta gtcggtttag gagaaaaagt tgatgacctt 1671061 caggaatttg atccagaatc ctatgtgtac ggactctttt cagatttagt ggaaaaagcc 1671121 gacgattaag aaaaaggccc caacatcttg gggccttttt cttttttatc ttcttacttg 1671181 ataggcgaaa tgataaaggc tgttatcagt ggataccagt cttgactcac cagaaaaaac 1671241 tctgaatggg atgatgtcat agtaatgaac ggaaacagat gtgtaatacg tatagtaacc 1671301 agcagctggc cccaaataca ttggaacctc aaatgttccg tttgcatcag tcgttcctga 1671361 agcagtttgt gttgtgtttc cgaccttcgt gtccgcttca aatcttacgg gcgcgtttgg 1671421 cactggctgt ccgttttggt cgagtaattt gccgcttact gtaatattgt acttgactcg 1671481 ccaatattga ccttgtccgt aattgatttt accgtatacc cctccatctg tgctgatatt 1671541 tgtgattgag gccttataag gtgcctcagc agcgtctgct tgctgtgccg ggaaacctat 1671601 tgtaaacagg gctgccagac ataacataaa caataaaccg atttttttca taaaaatcct 1671661 ccttaaaata gggttcatat acaatatcgg aataaattgg atgatattta gcgtattttg 1671721 gaaaagttaa tcgccgcttt gacaagataa aaacttgaca gtgtcattaa aaccgtgtaa 1671781 actaagttat cgtaaaggga tttgacttaa caaaggggag agctcaaatg tcactcgaaa 1671841 agacaacgag aatgaattat ctgtttgatt tttatcagtc gttgttgacg tcaaaacaga 1671901 agagctatat gtcgctttat tatttggacg atttctccct aggcgaaata gccgaagaat 1671961 atgaggtttc aagacaagct gtttatgata acatcaaacg aacagaagca atgcttgaac 1672021 aatatgaaga aaagctgctc cttttgaaaa agtttcagga gcgtaaagag atgtttaata 1672081 agctgaagga gcttgcttcc ggttcaaaag aagaggaaga aattacagct ctgattgaag 1672141 cgcttgagaa attagattag gaggcggcaa actatggcat ttgaaggatt agccgaccga 1672201 ctgcagcaga cgatttctaa aatccgcgga aaagggaaag tcagcgaaca agatgtaaaa 1672261 gagatgatgc gtgaggtccg tcttgcgctg cttgaggctg acgttaactt taaagtagtc 1672321 aaggattttg tcaaaaaagt aagtgaacgc gctgtaggcc aagacgtcat gaaaagtctg 1672381 acgcccggcc agcaggtcat taaagttgtt caagaggaac tgactgagct gatgggcggc 1672441 gaagagagca aaatcgccgt cgcaaaaagg ccgccgactg ttattatgat ggtcggtctc 1672501 caaggtgccg gtaaaacgac aacaagcggt aagcttgcga atctgctgcg caaaaagcat 1672561 aatcgcaaac cgatgctggt tgctgccgat atttaccgcc cagccgcaat taagcagctg 1672621 gaaacactcg gcaaacagct tgatatgcct gttttctctc ttggcgatca ggtcagtcct 1672681 gtagaaatag ctaaacaggc tattgagaaa gccaaggaag aacattatga ctacgtcatt 1672741 ttggatacgg cagggcgctt gcatatcgac catgaactga tggatgaact gaccaacgtc 1672801 aaagaaatcg cgaatccgga agaaattttc ctggttgtcg attcaatgac cggtcaggac 1672861 gctgtgaatg ttgccaaaag ctttaatgaa cagctcggtt taaccggtgt tgtgttgact 1672921 aagctggatg gagacacacg cggcggggct gcgctttcta ttcgcgctgt cacaaacacg 1672981 ccaattaagt ttgcaggttt gggcgaaaag cttgatgcgt tagagccgtt ccatcctgaa 1673041 cgcatggcat caaggattct cggcatgggc gacgtgctga cattgattga aaaagcacag 1673101 gccagcgttg atgaagacaa agccaaagag ctggaacaaa aaatgagaac gatgagcttc 1673161 acattggacg attttctgga gcagctcggg caagtcagaa acatggggcc gcttgatgag 1673221 cttctgcaaa tgatgccggg tgcaggtaaa atgaagggcc tgaaaaacat ccaagttgat 1673281 gaaaaacagc tgaatcatgt ggaagcaatc atcaaatcaa tgactgttct tgaaaaagaa 1673341 cagccggata ttatcaatgc cagccggcgg aagcggattg caaaaggaag cgggacatcc 1673401 gtacaggaag tcaaccgtct gcttaagcag tttgatgaaa tgaaaaaaat gatgaagcag 1673461 atgacaaaca tgtcaaaagg caagaaaaaa gggtttaagc taccttttat gtaatcggtt 1673521 atacatgata aaaccgttgt taagaaaaaa cactttacaa acacttttat cattgttaat 1673581 atactatctt gttgaaatat tttcggaggt gctagtaaaa tggcagtaaa aattcgttta 1673641 aaacgtatgg gagcaaaaaa atctcctttc tatcgtattg ttgtagcaga ttctcgttca 1673701 ccacgtgacg gccgtttcat cgaaacagtc ggaacttaca acccggttgc aaaaccagcg 1673761 gaagtaaaaa ttgacgaaga gcttgctctt aaatggcttc aaactggagc gaaaccatct 1673821 gatacagttc gcaacttgtt ctctagccaa ggaatcatgg aaaaattcca caacgctaaa 1673881 caaggcaagt aatgactgat caacacttgg aagatttgat tgtccacatt gtgacgccgc 1673941 ttgttgatca tccagatgac attcgcgtca taagagaaga aaccgatcaa aagattgcgc 1674001 tgcgcttatc tgtccataag tcagataccg gtaaagttat cggaaagcaa ggccggactg 1674061 caaaagcgat tcgaacagct gtatttgcag ctggcgtaca gtcttctaag aaagttcaat 1674121 ttgaaatatt tgactaaaag ggagagggcc ggcacctccc ctttttttac acgcaaaaaa 1674181 agggtaaact gatagaagct taggcaaaat agaaaagcct ggacgagtaa aagttttaaa 1674241 agcggggagc ttggtgcgat gcaaattatt caccgtgtag ccgttatgca agtcttaacc 1674301 gagcgcagta aagaaaagct tttagcttct tttgctgaga agaaacaaat gcttgaacga 1674361 gaatgcagcc agctctattt tcagcttaga aaacatgaga aagaacagca aaaccctaat 1674421 atgattgaac aatttaaaaa ggcaatagaa aagcgaaaag atgatataaa aatcattgat 1674481 tttcaaattg ctcaagtaca tacattgccg cttggcagtg agttgaaaga aaaggaagtc 1674541 gatgcgctgc tgacgattga agccggggat gactggcatg agaaaacagc agcgaacacc 1674601 atcgtcataa aagacggaaa agtaattgaa attcgccaga ggtgatcata tgacaaagcg 1674661 atggtttaat gtaggcaaaa tcgtaaatac ccacggaatc aaaggcgaag tgcgggtgat 1674721 ttcaaaaaca gattttgccg aagaacgata caagccggga aacacgctgt atttgtttat 1674781 ggacggccgt aacgaaccag tggaggtaac ggtaaacaca catagactgc ataagcaatt 1674841 tcatctcctg cagtttaaag aaagacaaaa cctaaatgaa gtagaagagc tgaaaaacgc 1674901 aatcattaaa gttcctgaag aagaattagg agagctgaat gagggtgaat tttatttcca 1674961 cgaaattatt gggtgtgaag tatttactga agaaggcgaa ctcatcggaa aggtcaaaga 1675021 aattttgacg cctggagcca atgacgtttg ggtcatcgga cgaaaaggaa aaaaagacgc 1675081 actcattcct tacattgaat cagtggttaa acatatcgat gtcagggaaa agaaaattga 1675141 gattgaactc atggaagggt taatagacga atgaaaatcg attttttgac gctgtttccc 1675201 gaaatgtttg aaggcgtgct cggctcatcg attcttcaaa aagcccagga aaaagatgcg 1675261 gtgcagtttc aagtcgtaaa tttccgagag tactctgata acaagcacaa tactgttgat 1675321 gattatcctt atggcggcgg ggcaggcatg gttctcaagc cccagcctgt ttttgacgcg 1675381 gtcgaggacc tgacatcaaa ggcagccgct gctccgcgta ttatcctcgt atgcccgcaa 1675441 ggtgagcgtt ttacccaaaa aaaagccgaa caattagcta aggaagagca tttgctgttc 1675501 atttgcggcc actatgaagg ctatgatgaa cgcattcgcg agcacttggt aacggatgaa 1675561 atatcaattg gcgactttgt tctgacgggc ggtgagctcc ctgcaatgat gatcgcagac 1675621 agtgtggtca gactgcttcc gggtgtactg ggtaaagagg cttcccatat tgaggattcc 1675681 ttcagcaccg gacttttaga gcacccgcat tatacaagac cggcagatta caaaggttta 1675741 aaagtgcctg aaacactctt gtcaggaaac catgcaaaaa ttgaagaatg gcggaataaa 1675801 gaatcgatca gaaggaccta cctaagacgt ccggatctgt tgaaagacca cccgcttaca 1675861 gagcagcaaa gaaagtggat ttctgaatgg gaaaaagaat agattttatt gcataggcta 1675921 tgaaattgtg ataagatact acttgtggct taagcgggct tatccgctgc aagcttgaaa 1675981 acgatgttcc gctgtgccgg tttttgtggc caagagcatc tgttggaagg agttgaaaac 1676041 gatgcaaaaa ctaattgaag atatcacaaa agaacagctt cgtactgatc ttcctgcgtt 1676101 ccgtcctggt gacactttac gtgtacacgt taaagttgtt gagggtaacc gtgagcgtat 1676161 ccagatcttt gaaggtgttg tgattaagcg tcgtggtggt ggaatcagcg aaacgttcac 1676221 agttcgtaag atttcttacg gtgttggcgt tgaacgtact ttcccagtac acacaccaaa 1676281 aatcgcgaaa atcgaagttg tacgttacgg taaagtacgc cgtgctaaac tttactacct 1676341 gcgtgaactt cgcggaaaag cggctcgtat taaagagatc agacgataat gataacgaac 1676401 gaaaagagct tgttacctgt aacaagctct ttttttatac agaatttgaa aatgccggac 1676461 aggcatcgta aaatacataa aggacaacaa tgaatcatgc atactgaaga taaaggcggt 1676521 gttcgtgtca catgacaatt caatggttcc cgggccatat ggcaaaagca agaagggaag 1676581 taaccgaaaa attaaaatta atcgatatcg tatatgaatt ggtagatgcc agaattccaa 1676641 tgtcatcaag aaacccaatg attgaagata ttctaaaaaa caagccgcga attatgctgt 1676701 taaacaaggc tgacaaagca gatgcggcag ttacacagca gtggaaagag cactttgaga 1676761 accaggggat ccgctctctg tctattaatt ctgtaaatgg acaagggtta aatcaaattg 1676821 tgcctgcatc aaaagagatc ctccaagaaa aatttgaccg gatgcgtgcg aaaggtgtga 1676881 agccgagagc gattcgcgct ttgattatcg gcattccaaa cgtcggaaaa tcaacgctca 1676941 tcaaccggct tgcaaagaaa aacatagcaa aaacgggaga cagacctggt attacgactt 1677001 ctcaacagtg ggtcaaagtt gggaaagaat tagagctatt agatacaccg ggaattttgt 1677061 ggcctaaatt tgaggatgag cttgtcggtt tgagactggc agtcaccggg gctattaaag 1677121 actcgattat caatttgcag gacgtggccg tgtttggtct tcgttttctc gaagaacatt 1677181 acccagaacg gcttaaagag cgttatggcc ttgatgagat cccagaggac attgccgagc 1677241 tgtttgatgc aataggtgaa aagcggggct gtctcatgag cggtgggctc atcaactacg 1677301 ataagacgac tgaagtcatc attcgcgata ttcgcactga aaagttcggc aggctgtcat 1677361 ttgaacagcc gacgatgtaa aggcgcgcag aaatgcgggt ctttattttt tcttggctga 1677421 accgatacat acagtaaggg agaagagaaa gtgaatacat taaccgtaaa ggacattaaa 1677481 gaccgtttgc aggaagtgaa ggatgcacaa gacccattta ttgcccaatg cgaaaacgac 1677541 ccgagaaaaa gcgttcaaac gcttgtagag caatggctta aaaagcaagc gaaagaaaaa 1677601 gcgctgaaag aacaatgggt gaatatgact tcctatgaaa ggctggcaag aaacaaagga 1677661 tttcgcttga ttgcaggtgt tgacgaggtc ggccgggggc cattggcagg accagttgtc 1677721 gccagcgcag tcatccttcc agaggaatgt gaaatacttg ggctgacaga ctccaaaaag 1677781 ctttcagaga aaaaacgcga ggaatattac gagcttatta tgaaggaagc actggcggtc 1677841 gggataggaa ttgtagaagc tactgtgatt gatgagatca atatatatga agcttcaaaa 1677901 atggcaatgg tgaaagcgat acaggatttg tcggatacac ctgattattt gcttgttgac 1677961 gcaatgacac ttccgctcga cacggctcag gcgtcaatta taaaaggcga tgccaaaagc 1678021 gtgtctattg cggcaggtgc gtgtatcgca aaagtgacga gggaccgaat gatgagcgct 1678081 tatgccgaaa cgtatcccat gtacggcttt gaaaaaaata aaggctatgg gacaaaagaa 1678141 catttggaag ctctcgctgc atacggccca actgaattgc accgcaaaac tttcgctcct 1678201 gttcaatctt tcagataaat caccatggac aaggaggcac ctttttaaaa tgaacatacg 1678261 aaatgatgtg caaaaggcgc tgcagcacct tttcgggcgt acagccgtcc cgcaggaaac 1678321 atcaaaagta aacgaagcgc taaacgggga gaagcgtctc ctcttaggaa aagtgcttcg 1678381 tttactagga gatcagcatg ccctgatcca agtcggcaat caaactgttc agggaaaact 1678441 tgaaactcag cttcgtcctc aggcatacta ttggttttcc tacgaaaaaa aaacggcaga 1678501 gcaaacaggc cgtcttcagg tcgttcaaag ctttgatcaa aatcctaaaa ccattcagga 1678561 tgcagctggc aaacttttaa atgctatttc agtgaagacg tcaaacgcag ctctcatgat 1678621 gacaggagcg atgctgaaaa gcaaaacacc cgtaacagaa aatgatatca aaacagctgt 1678681 ccgctggatg gacacgctgc cttcgcaaga cacaaaaaaa gcagttgaaa cggttctctt 1678741 cgctttaaag cgtgatcttc ccattcactc cgagattttg aatggtgttc acgctgtgaa 1678801 atcgcctgtt ccgttgcatc agcacgtatc ccagctgcta caggcaatcg accaaaaccc 1678861 tcagcagagc caaatgatgt caaagctaaa ggaagcagtc acggtgcttt taaatagtga 1678921 aatcgatgtc catgcagaac ggctgattga taagcttatt tctttaaccg acaatacgaa 1678981 agcaccttct ccgacgaata cagctggaag cagggagctt agcacaccag ctggctcccc 1679041 cggaaaagcc agcctgccga ttgcaaatca cacagcagaa cagggaagca tacaagaaga 1679101 gcctgttaaa acagcagcag acattccaat taaagaagcc cgccagctgc tggtgaagct 1679161 gacggaatct gctgaaaaaa acagtctcca aattgtgaaa gaagcagcaa attggattaa 1679221 agcggctgct tcatcgggtg atagtaagtc acttgcagct tcagctgttt tacaggcggc 1679281 acaagtcaca gatcaggaag ccgaagtctt tttaaaggct gttcagcaga cagcacccca 1679341 tttggcggat aaggcagatg ttctttcttt cttatccaaa gtgaaaacgg caatcggcgc 1679401 aagggacgag gttgcgttca ttaaagcgtt tgaacaagga agcgcagtca catctggcga 1679461 aatgcaatcc atcaagctgg ctctttctgc cttaagagca tcgcatgagg tagccgaacc 1679521 agtcaaacaa gaagccgatc agctttttca taaattaaat ggccagcttt tcatgcagca 1679581 ggaccatcca tcatacagcc aaattgtaat gtcatttccg atgttttcga agtcaggggt 1679641 tcaggacatg actgttctgt ttaaaggaaa gaaagaagcg gatggaaagc ttgatccttc 1679701 ccattgccgc cttttgtttt tgctgcagct tgatacacta aaagaaaccg tcgttgattg 1679761 cttggtacag caaaaagtca tgaccattac aatagagact gatttcgagc tgcaggctgc 1679821 gatcgatccg atggtgcccg cgcttaaaca ggggctaaag gaaatggggt acagcctttc 1679881 aggggtaaac gctaaaaaaa gggttcacac cgaagaaaag gcttcaatcg atcaatatat 1679941 aacaagtatc agtgatcagg aagtggatgt gaaaatatga aagagcagac accgatcaga 1680001 aaagctgttg ctctccatta tgacgaacaa aaagacaagg cgccgagagt gattgccaca 1680061 gggaagggcc atgtagctga caacattata aaagaagcga aaaaagcagg ggtcccgatt 1680121 caagaagatc ggacccttgt cgaattaatg cgccatttga cggtagatga tcaaattcct 1680181 gaagctcttt atgaaacggt agccgagatt ttttcattca tttacaaatt ggacgaaagc 1680241 gtaaaaaaca aaaaatagct aaaatattcc ccatccttct ttgaaattta tgtttttaat 1680301 aaagtaaaag tttgaatgtt tagaaggatt aaaagatttt gcatcgaact gtagacaatt 1680361 cttccagtat tattatagaa tgaaagcgca gtctatttta gttttgttac ataagttagg 1680421 aggatgggaa atgaatatcc atgagtacca gggaaaagaa gtcctcagaa aatatggggt 1680481 atctgttcct gaaggtaaag tggcttttac agcagaagaa gcagttgaga gtgcaaagag 1680541 cttatccagc tcggtttatg tcgtaaaggc tcaaattcat gctggcggtc gaggcaaagc 1680601 tggtggggta aaaatagcaa aatcattaga cgaagtaaaa gcgtatgccg aagaactatt 1680661 agggaagacc ctagttacac atcagacggg tccggacggc caagtaataa aacgcttact 1680721 tattgaagaa ggctgcgata ttaaaaaaga atattacatc ggtctagtgc ttgaccgcgc 1680781 cacttcaaga atcgttttaa tggcttctga agaaggcgga acggaaattg aagaggttgc 1680841 ggagaaaaca ccagaaaaaa tcaaaaaagc tgtcattgat ccagctgttg gccttcaagg 1680901 ctatcaagcc agagaaattg cattcgctat taatattcca aaagagctcg tgggaaaagc 1680961 tgctaaattt atgcttggac tatataaagc gtttgttgag aaagactgct caatcgccga 1681021 aatcaatccg cttgttgtga ctggcgacgg aaatgtgatg gcgcttgatg caaaattgaa 1681081 ttttgacagc aatgcgttgt accgacaaaa ggacattatg gaatacagag atttggatga 1681141 agaagatccg aaagaaattg aagcgtccaa atatgatcta agctacattt cccttgatgg 1681201 aaatatcggc tgtatggtaa acggcgcggg acttgcaatg tctacgatgg atattatcaa 1681261 gcattatgga ggagaaccgg ccaacttcct tgatgtgggc ggcggtgcaa ccgcggaaaa 1681321 agtcacggaa gcatttaaaa tcattctttc tgatcaaaac gttaaaggga tttttgtcaa 1681381 cattttcggc ggcattatga aatgtgatgt catcgcagaa ggggttgttg aagcgactag 1681441 acaagttggt ttgacattgc cgcttgtcgt ccgtcttgaa ggcacaaacg tggatctagg 1681501 gaagaaaatc cttagtgaat caggattaaa cattacatct gcggaatcaa tggctgacgg 1681561 cgcgcagaaa atcgtatcct tagtttaaga aagaatgaaa ggcaggggac caaataatga 1681621 gtgttttcat taataaagat acaagagtta ttgtgcaagg gattacaggt tctaccgctt 1681681 tatttcatac gaagcagatg cttgaatacg gcacaaatat cgttggcggt gtaacacctg 1681741 gaaaaggcgg aacagaagcg gaaggtgttc ctgtatttaa tacagtggct gaagcagttc 1681801 aaacaaccgg cgctaacgcg tctgttatat atgtgcccgc accgtttgca gctgatgcga 1681861 ttatggaagc ggtagatgcg gagcttgatc tcgtgatttg tatcacagaa catatcccgg 1681921 ttttggatat ggtgaaggtc aaacgcttca tggaaggcaa gaaaacgaga ctgatagggc 1681981 cgaactgtcc tggtgtcatt acgcctgaag aatgtaaaat cggcattatg cccggataca 1682041 tccataaaaa gggtcatgta ggcgttgtat cacgttcagg aacattaaca tacgaagcgg 1682101 tgcaccagct ctcagaagcg ggtgtagggc aatctacagc tgttggaatc ggcggcgacc 1682161 ctgtaaatgg aacaaacttt attgacgttt taaaagcgtt taacgaagat cctgacacac 1682221 acgcagtcat catgattggc gaaatcggcg gtacggccga agaggaagcg gcagagtggg 1682281 taaaagccaa catgacaaaa ccggtagtcg gttttattgg cggtaaaaca gcacctcctg 1682341 ggaagcgcat ggggcatgca ggcgccatta tttccggcgg gaaagggaca gctgatgaaa 1682401 aaatcaaaac ccttaatgca tgcggaatcg aagttgcaga gacaccttct gtcatgggtg 1682461 aaaccttaat caaggtgctg aaagagaaga acttgttcga aacttgtaaa acgcattaat 1682521 aaaaaaggga cagccgtcaa ggctgttcct gctttttcta acaaaaggag gtcaatctat 1682581 tggatcaggc cgctgtctgc ctaacgattt gcagaatcaa tcaattatta tccccatccc 1682641 ttctattaaa atggtggaaa gccgatccgt ctatgtcgct gacatcaccc gtgttacaaa 1682701 cggttactcg tgatcaaata aaagcagctg cattaaaaaa cgaaatagaa caattttatc 1682761 caaagctccc gcgtgtactt gctgcttatc gtgagcaagg cattaacacc atccctattt 1682821 cttcaaagca atatcctttc tggcttaaaa gcatttatga tccccctgcc gtactgtttg 1682881 caaaaggtga tatgactctt ctttcgaaag ggagaaaaat tggaattgta ggcacaagaa 1682941 atccaacagc ttatgggaaa caagttgtca atcatcttac aaaagagatc tgtcgtaaag 1683001 gttgggtgat tgtcagcgga ctggcgtctg ggatagacgg aatgtcccat gctgcaagta 1683061 ttaaggcgaa ggggcggaca attggcgtca ttgcaggcgg atttcaacac atttatcccc 1683121 gagaaaacct tcagttagca gatcacatgg ctaaacacca tatcctgctg tcagagcacc 1683181 cacctgaaac taaaccccaa aaatggcatt tccctatgag aaaccgtatt atcagcggac 1683241 taagtgaagg cgttattgtc gttcagggca aagaaaaaag cggttcgctg attactgcct 1683301 atcaagcatt ggaacaaggg agagaggtat ttgccgtacc cggttcattg tttgaccctt 1683361 acgccggagg tcctataaaa ctgatccagc agggggctaa agccatatgg tcagcagagg 1683421 atattttcga ggaacttcct gagagaaacg ttcaatatac ggaacccttt tgaattatcg 1683481 tttgacaaac ggtattgtaa tatttaataa tagtgaggat ttaaagttgc atattgtttt 1683541 ctatttaatt aatgacgttc atgataaaga atgaaatgtt gaaagccaaa taaagacagc 1683601 tgcaaaaata aaattgaaat atcttgaaaa gagagagaac acctcttgag ggggatgaaa 1683661 atgtctgatt atctagtcat cgtggaatcg cccgctaagg cgaaaacgat tgaacgttac 1683721 ttaggtaaaa aatataaagt aaaagcatca atgggacatg tccgggatct tccaaaaagt 1683781 caaatgggag ttgacataga acagaatttt gaaccgaaat atattaccat tcgaggtaaa 1683841 ggcccggtat taaaagagct gaaaacggct gcgaaaaaag ccaaaaaagt gtatctcgca 1683901 gctgaccccg acagagaagg ggaagcgatt gcatggcatt tggcacacag tcttgattta 1683961 gatctcaact cagactgccg tgtggtgttt aacgaaatta caaaagacgc tattaaggaa 1684021 tcgtttaagc atccccgcat gatcaatatg gatttagtgg atgcacagca agcgagacgt 1684081 attttagaca ggcttgtcgg atataaaatc agtccaatct tatggaaaaa agtcaaaaaa 1684141 gggcttagcg caggacgcgt gcaatccgtt gccctccgtt tgattattga ccgtgaaaaa 1684201 gagattaacg actttaagcc tgaggaatat tggacaattg acggtacgtt cttaaaaggt 1684261 caagaaacct ttgaagcgag ctttttcggg aaaaacggca aaaaacttcc tttaaatagt 1684321 gaagctgatg taaaagagat tctttctcag ctcaaaggga atcaatatac agttgaaaaa 1684381 gtaaccaaaa aggaacgcaa acgtaatcct gctttgcctt ttaccacttc taccctgcag 1684441 caggaagcgg ctcgcaagct caatttcaga gcgaagaaaa cgatgatgat tgcacagcaa 1684501 ttatatgaag gaattgattt aggaagagaa ggaacggttg gtctgatcac gtatatgaga 1684561 acggattcaa cccgtatttc aaatacggct gttgatgaag cagctgcatt tattgatcag 1684621 acatatggaa aagagttcct aggcggaaaa cggaagcctg cgaaaaagaa tgaaaatgcc 1684681 caggatgccc acgaagcaat tcggccgaca tcagttctta gaaaaccaag tgaattaaaa 1684741 gcagtcctcg gcagagacca aatgagactg tataaattaa tttgggagcg ttttgttgcc 1684801 agccaaatgg caccggctgt tctcgataca atgagtgtcg acctgacaaa caacggtttg 1684861 acatttcgtg caaatggaag taaagtcaag ttttccgggt ttatgaaggt gtatgttgaa 1684921 ggaaaagacg atcaaatgga agaaaaagac cggatgctgc ctgacttaca agaaggcgac 1684981 acggtattat caaaagatat agaacctgag cagcatttta cccagccgcc tccgcgatat 1685041 actgaggccc ggcttgttaa aacccttgaa gaacgcggta tcggccgtcc atccacatat 1685101 gctccgacac ttgatactat tcagcggcgc ggctacgtgg cattggataa taaacgtttc 1685161 gttccgactg aattaggtca gatcgttctt gacttgatca tggagttttt ccctgagatc 1685221 attaacgttg agtttacagc taaaatggag agagatcttg atcatgttga agaaggaaat 1685281 accgaatggg tcaagattat cgataatttc tacaccgatt ttgaaaaacg cgtcaaaaaa 1685341 gccgaatcgg aaatgaagga agttgagatt gaaccagagt atgctggaga ggattgtgaa 1685401 ttgtgcagtt ctccaatggt atataaaatg ggacggtacg gtaaattctt agcttgctcc 1685461 aacttccctg actgccggaa cacgaaaccg attgtgaaac aaatcggtgt gaagtgcccg 1685521 agctgcggag aaggaaacat tgttgagcga aaatcgaaaa agaaacgggt gttttacggc 1685581 tgtgaccgtt atccggactg tgaattcgta tcatgggaca aaccaattga acgaaaatgc 1685641 ccgaaatgcg gaaaaatgct cgtcgagaaa aaactcaaaa aaggtataca agtccaatgc 1685701 gtggaatgcg attataagga agaaccacag aagtagcggt gagcagggtc ttgctcacct 1685761 tctttgtgtg ttaaaagaag gccttgaata ataaactagg agatgtgaaa gatgaaccaa 1685821 caaacagtga atgtaatcgg agccggactc gcaggaagtg aagcagcatg gcagcttgcc 1685881 aaacgtggga ttcaagtcaa attgtatgaa atgcggccag ttaaacaaac gcctgcgcat 1685941 catacagata aatttgctga gcttgtctgc agcaactctc ttcgctctaa tacacttgct 1686001 aacgctgtcg gtgtattaaa ggaagaaatg cgtgcgcttg attcagccat tatcgctgcg 1686061 gctgacgaat gttcggtgcc tgccgggggc gctcttgcag tagaccgtca tgaatttgcc 1686121 gcaagtgtga caaatcgggt gaaaaatcat ccaaacgtaa ccgttattaa tgaagaagtg 1686181 actgaaattc ctgaaggccc tactatcatc gcaacgggtc cgttaacatc tgaatcgctg 1686241 tctgcccagc tgaaggagct gactggagag gactatttat atttttatga cgcagcggcg 1686301 ccaattgtag aaaaagacag ccttgatatg gataaagtgt acctgaaatc ccgttatgat 1686361 aaaggtgaag cagcatattt gaactgcccg atgacagaag aagagtttga ccgttttcat 1686421 gaagcattaa catcagcaga aacagtgccg ttaaaagaat ttgaaaaaga gattttcttt 1686481 gaaggctgca tgccgattga agtcatggca aaacggggta agaaaacaat gcttttcggt 1686541 ccgatgaaac cagttggtct agagcatcct gttacaggaa aacgccctta tgccgtcgtt 1686601 cagctcagac aggatgatgc tgcgggaaca ctttataata ttgtaggatt ccagacacat 1686661 ttaaaatggg gagaccaaaa ggaagttctc aagttgattc caggacttga aaatgtagaa 1686721 atcgtcagat atggcgtgat gcatagaaac acatttatta actctccaag cctgttaaag 1686781 ccgacttatc aatttaaaaa ccgcagtgat ctgttctttg caggccaaat gacgggagta 1686841 gaaggatatg tggaatcagc tgcctcagga cttgtagcag gcattaatgc ggcgaagctt 1686901 gtattgggag aagagcttgt gatcttccct caggaaacag caattggcag tatggcacat 1686961 tatattacaa caacaaacca gaagaacttc cagccgatga atgcaaactt tgggcttttg 1687021 aaagaattgc cagttaaaat taaaaataaa aaagaacgaa atgaacaata cgcgaaccgt 1687081 gcgattgaaa caattcaaac aatttcgaaa acaatatagg tattgattgc aacctgagcg 1687141 cgatttgtga taccatttaa aagcccttcc tggggaggta ttaggcatgg agaatgttaa 1687201 gaatttcgta aagttattcg ttgaatattt acaaattgaa aaaaattatt cacaatatac 1687261 tattgtgaat tatgtggatt caattgaaga attcgagact ttcctgcgcg ttcaaggtat 1687321 aaatggattt gaagaagctg catatcaaga tactaggatt tttttgacag aagcctatga 1687381 aaaaggttta tcgagaagaa caataagcaa aaagatatct gcattaagaa gcttttataa 1687441 gtttctgatg cgggaaaagc ttattgaaga aaatccgttt cagcttgttc atctgccaaa 1687501 acaggagaaa cggataccga agtttctata tcaaaaagag cttgaggagc tgtttgaagt 1687561 ttcagatata agccagccgg ccggaatgag ggatcaagcg ctgttagagc tgctctatgc 1687621 cactggaatg agggtcagtg aatgctgttc cataactatt aacgacgttg atttatttat 1687681 ggacactgtg cttgttcacg gtaaaggcaa gaagcagcgc tatatcccct ttgggtctta 1687741 tgcccgcgaa gcgttgaagg tatacatgaa tagcggaaga cagtgcttgc tgatgaaggc 1687801 aaaagaacct catgatctat tattcgtaaa tcaaagaggc ggaccgctta cagcccgtgg 1687861 catcagacat attttaagcg ggcttgttca aaaagcgtca agcactttac atatccatcc 1687921 gcatatgctt cgacatacgt tcgccacgca tctgttaaat gaaggagcgg atttgagaag 1687981 cgttcaagaa ctgctcgggc attccaatct gtcttctaca cagatataca cgcacgtttc 1688041 gaaggaaatg ttgagaaaca catatatgtc tcaccatcca agagcattta agaaaaatta 1688101 aaggaggccc tttatgtcat cttttcatgc gaccacaata tttgccgtac agcataaagg 1688161 acgaagcgct atgtccggag acggccaagt aacatttggt caggctgttg tcatgaaaca 1688221 cacggcacgg aaagtgagaa aactgtttaa cggcaaagtt cttgctggtt ttgcgggatc 1688281 tgttgcagac gctttcactt tattcgaaaa gtttgaagct aagcttgaag aatataacgg 1688341 caacttaaaa cgggcggctg ttgagcttgc aaaggaatgg cgcagtgata aagtgctaag 1688401 aaagctcgaa gccatgctga ttgttatgaa tcaggatact ttgcttctcg tatcgggaac 1688461 aggcgaggtg atcgaaccag atgacggcat tctcgcgatt ggatcaggag gcaattacgc 1688521 tttggcagcg ggaagagcac tgaaaaagca tgccggggaa agcatgtctg caagtgagat 1688581 tgccagagcc gcgttagaaa cagcaggcga aatttgtgtt tacacgaacg atcaaatcat 1688641 actggaagag cttgaataga aaggacttga ggcgcatgga aaaaaaaccg ttaactccta 1688701 gacagattgt agatcggtta gaccaatata ttgtcggtca gcaaaatgcg aaaaaagctg 1688761 tcgccgtggc attaagaaac cgctatagaa gaagtcttct ggatgaaaag ctgaaggacg 1688821 aggtcgttcc gaaaaacatt ttaatgatgg gtcctaccgg cgtcgggaaa actgaaattg 1688881 ccagacgaat cgctaagctt tcaggtgcgc catttatcaa aattgaagct actaaattta 1688941 ccgaagtcgg ctatgtaggc agagatgttg aatcaatggt cagagatctt gtggagactt 1689001 ctgttcggct tataaaagaa gagaaaatga atgaagtaaa ggaacaggca gaagaaaatg 1689061 caaacaaacg cattgttcgt ctgttagttc ctgggaagaa aaaacaatct ggtgttaaaa 1689121 atccgtttga aatgtttttt ggaggcagcc agccgaatgg tgaagatgag gcggagagcc 1689181 aggaagaagc aaacatcgaa gaaaaaagaa aacgaatggc gcatcagctg gctttaggag 1689241 agctcgaaga ctactatgta acagtagaag tcgaagaaca gcagccttct atgtttgaca 1689301 tgctgcaggg ctcgggtatg gagcagatgg gtatgaacat gcaggatgcg ctgagcggat 1689361 taatgccaaa gaaaaagaag cggcgcaaaa tgacagtcag agaagccaga aaagtcctga 1689421 cgaatgaaga agcaagcaaa ctcatcgata tggatgaagt cggccaggaa gctgttcaga 1689481 gagcagaaga gagcgggatt atctttatcg atgagattga taaaatcgca aagaacggcg 1689541 gtgcatcttc ttctgccgat gtttcaagag aaggtgttca gcgggatatc cttccgattg 1689601 ttgaaggttc taccgttgtc acaaaatatg gttctgtaaa aacagaccat gtattattta 1689661 ttgcagcagg agcgtttcat atggccaaac cgtctgattt gattcctgag ctgcaggggc 1689721 gtttcccgat tcgtgtagaa ctgaacaaac tcacggtaga cgacttcgtg agaattttgg 1689781 ttgagccgga taatgcgctg ctgaaacaat atcaggcatt attgcagaca gaaggtatat 1689841 ctcttgaatt ttctgacgaa gctattcata agattgctga agttgcttat catgtgaacc 1689901 aggacacaga taatatcggt gcgagacgcc ttcatacaat acttgaacgc ctattagaag 1689961 atttgtcgtt tgaagctcca gatgtaacga tggagaaaat aacgattaca ccacagtatg 1690021 tcgaagaaaa gctcggaacg atagccaaaa acaaagattt aagtcaattt atattgtgaa 1690081 aaatttaata tgaggaatgt ttaggaggat tatttatcat ggctttatta caaaaaacaa 1690141 gaattattaa ctccatgctg caagctgcgg cagggaaacc ggtaaacttc aaggaaatgg 1690201 cggagacgct gcgggatgta attgattcca atattttcgt tgtaagccgc agagggaaac 1690261 tccttgggta ttcaattaac cagcaaattg aaaatgatcg tatgaaaaaa atgcttgagg 1690321 atcgtcaatt ccctgaagaa tatacgaaaa atctgtttaa tgtccctgaa acatcttcta 1690381 acttggatat taatagtgaa tatactgctt tccctgttga gaacagagac ctgtttcaag 1690441 ctggtttaac aacaattgtg ccgatcatcg gaggcgggga aagattagga acacttattc 1690501 tttcgcgttt acaagatcaa ttcaatgacg atgacttaat tctagctgaa tacggcgcaa 1690561 cagttgtcgg aatggaaatc ctaagagaaa aagcagaaga aattgaagag gaagcaagaa 1690621 gcaaagctgt cgtacaaatg gctatcagct cgctttctta cagtgagctt gaagcaattg 1690681 agcacatttt tgaggagctt gacggaaatg aaggtcttct tgttgcaagt aaaattgctg 1690741 accgtgtcgg cattacccgt tctgttattg tgaacgcact cagaaagctg gagagcgccg 1690801 gtgttatcga gtctagatca ttaggaatga aaggtactta tatcaaggta ctaaacaaca 1690861 aattcctaat tgaattagaa aatctaaaat ctcattaatc acaaaaagaa ccctttttga 1690921 gggttctttt tttatttcaa ataaaggaaa tcaataagct ttatttcctg ggttgaaagt 1690981 ctttctatgt aataatttta ataaattttg catttttctt caaaaagttt caaaaatgcc 1691041 gaaaagaaag gagaaaaaac agaaattctg ctattttcag gcttatatca aggcgagaaa 1691101 tgtagttcta acaatctagg actttatacc tagttgcaaa atagataatt gtgaggacat 1691161 ttttttacac gaacttcata gactttatgc ctgttatttc ttacaataag catatagttt 1691221 tacaattctc gacaaggata ttgagggtga aaaaaactga aatggaggta agtggatttg 1691281 agcttatttt ctggaacgat acaaaatctt gaaaatgcct tgagcagagc ggatattaag 1691341 caaaaagtca taactaataa tatcgccaat atagatacac cgaactataa ggcaaaaaaa 1691401 gtctctttcc aaaatttatt agatcaagaa tcctcgcgtc ttgaagcgat aaaaacagac 1691461 tatcgtcatg ttgatttttc tgatactgat tcgaattatt caattgttgc gagcggagat 1691521 acatcgtatc agcaaaacgg aaacaatgtt gatgttgaca aagagatgac agaattggcg 1691581 caaaatcaaa tcaactatca agctttggtt gaaagaatga acggtaaatt taattcgctg 1691641 aagaccgtat taacaggagg aaaatgatga cagcttttca tagcttaaat gtttcagcat 1691701 cggctttaac agctcagcga gtcagaatgg acgttgtatc atctaactta gcaaatatgg 1691761 atacgacaag agctaagcag gtgaatggag agtgggtgcc ttacagaaga aaaatggttt 1691821 cccttcagtc aaaaggtgaa tcgttctctt ccattctcaa ttctcaaatg agcggaagcg 1691881 ggaatgctgg aaacggtgtg aaggtttcaa aaattacgga ggatgattcg gattttaatc 1691941 ttgtctatga tccgacagac cctgatgcaa acgctgaagg atatgtacaa aagcctaatg 1692001 ttgatccatt aaaggaaatg gttgatcttg tcagcagcac tagatcatac gaggcgaatg 1692061 tcacggcgat gaatgccaca aagggaatgc tgatgaaggc gttagaaatc ggaaagtagg 1692121 tgaatgaatg tgattaatgc aatttctcct tttcaggttc aaaatactca aaacactcaa 1692181 aatgcaacaa atcaagtaaa caatagccaa aaaacagatt cttcaaatca aacaagcttt 1692241 tcggagcttt taaaaaactc tattagttcg ttaaatgagt cccaagtagc ttctgacaac 1692301 atgactaatg ccttggctgc aggaaaagat gtaaatcttg atgaggtcat gatcgctgct 1692361 caaaaagcta gcatctctct aactgcagca acagagttcc gcaataaagc tgtggaagct 1692421 tatcaggaga ttatgagaat gcaaatgtag ggggtctgac gatttagaga aagagtggaa 1692481 tgaccggggg ttaacatgaa tcgtactcta atgcaaatga aaaacaaaac gagtgagttt 1692541 tggaaaaata gatctaaatt acaaaagatt ttaatggtta gtgctttagc ggcaattatt 1692601 attattggaa ttattattag tgtttttgct tcaaattcta aaatggcgcc gctgtacaaa 1692661 gatttgtctg ccgaagaagc aggacaaatc aaagaagaat tggatgcaaa aaaagtgcca 1692721 aacgaacttt cgaatggcgg tacagtgatt agtgttccgg aggatcaggt tgattctttg 1692781 aaagtgcaga tggctgcaga aggacttcct aaaacgggat caattgatta ttcgtttttt 1692841 ggacagaatg ccggctttgg tttgacagac aatgagtttg atatggtgaa agtgaaagct 1692901 acacagacag aactgtcaaa cttgatcaat gaaatggacg gtattaaaaa ttcaaaagta 1692961 atgattaatc tcccgaaaga cgctgtgttt gtcggtgaag agcaatctgc agcatctgca 1693021 tcaatcgttt tgcagattca accgggttat acacttgatc aaagccaaat caacggatta 1693081 tatcatctgg tatctaaaag cgtgccaaac ctaaaagaag ataacatcgt catcatggac 1693141 caaaattcta catactacga caaatcagac agcgatgcag ggtcctacgc ggatagttat 1693201 tcttctcagc aaggaattaa gtctcaagtt gaaaaagaca ttcaaaaaca tgtacagtca 1693261 ctgctgggta cgatgatggg ccaagataaa gtcgttgtct ccgttacagc agacattgat 1693321 ttcacaaaag aaaatcggac agaagacatt gtcgaacctg tggataaaga aaacatggaa 1693381 ggcattgcag tcagcgctga aaaggtatct gaaacatatc agggcgacgg tgcagccaac 1693441 ggcggaactg ccggaaccgg cgaggaagat gttacaaatt ataaggctga cggtgaaaat 1693501 accgaaagcg ggaactacga aaaaaacagc aacaaaatca attacgaggt taaccgaatt 1693561 cataaagaaa tcgctgaaag tccttataag gtcagagatt tagggattca agtaatggta 1693621 gagccgcctg atgccaaaaa cactgcgtcg ctatcaactg aaagacagga tgatatacaa 1693681 aaaatccttt caactgtagt cagaacatct ttggataaag atgaaacgca aaatcagaat 1693741 ttatctgatg ctgatatcaa taataagatt gttgtttccg ttcagccatt cgacggaaaa 1693801 gtcaatttgg atacaaatac ggaagaatcc tcaggtatcc cgctgtgggc atatattgta 1693861 ggcggtgttt taatcgcagc gatcattgtt ctgatcatta tgcttatcag aaagaaacgg 1693921 gcgcaagagg atgaatttga ggaatatgag tatgaggttc ctcaagaacc aatcaatttg 1693981 cctgatatca acgaagagga aaatgaaaca gcggaatcag tcagacgaaa acagcttgaa 1694041 aagatggcga aagacaagcc ggaagatttt gcaaaactgc tgagaagctg gctggccgag 1694101 gattaggagg aattagaaat ggcgagacgt gatcaagata agcttacagg aaaacaaaaa 1694161 gcagccattc tcatgatttc cttggggtta gatgtgtcag cttctgtcta taagcactta 1694221 accgatgaag aaattgaaag gcttactctg gaaatatcag gtgttcgaag cgtcgatcat 1694281 caaaaaaagg atgaaatcat agaagaattt cataatatag ccattgcgca agattatatt 1694341 tctcaaggcg gtttaagcta tgcaagacaa gttctggaaa aggcgcttgg agaggataag 1694401 gcggagaaca ttctaaacag gctgacttct tctttgcagg ttaaaccatt tgattttgcc 1694461 agaaaagcgg agccagaaca aattttgaat tttatccagc aagagcatcc gcagacgatg 1694521 gcgttaatct tgtcttattt agatccagtg caggccgggc aaattttatc cgagctgaac 1694581 cctgaagtgc aggctgaggt tgcgagaaga atcgcggtca tggatagaac gtctccagaa 1694641 ataattaacg aggtagaacg gattctggaa caaaaattat cttctgcatt tactcaggat 1694701 tatacacaaa caggcggaat tgaagctgtt gtggaagtgt taaacggggt agacagaggg 1694761 acagagaaga cgatcttgga ttcattggaa attcaggatc ccgatcttgc tgaagagatt 1694821 aaaaagcgga tgtttgtctt cgaagatatt gtcacacttg ataaccgtgc aattcagaga 1694881 gtcattcgcg atgttgagaa cgacgatttg ctcctttcat taaaggttgc aagcgaggaa 1694941 gtcaaagaaa ttgtgttcaa caatatgtca cagcgtatgg ttgaaacctt caaagaagaa 1695001 atggagttta tgggccctgt acgtttgaaa gatgtagaag aagctcaatc aagaattgta 1695061 agcatcgtca gaaagcttga agaagccggt gaaattgtaa tagcaagagg cggaggggat 1695121 gatattattg tctaatatca ttaaacaaga atcatctatt tctccacaaa aggaaaaaag 1695181 aaaactttct atacaagagg tgcgtattga tcattctcac cttttgcagg ctgaagagaa 1695241 cccggaggcg cttatggccc gagtgaaaga ggaagctgac cggatttctg agcaggcaaa 1695301 cagtcatata gaaaatattc gccgtcaaat tgaacaggag aaaaacgatt gggcggctga 1695361 aaaacagaag cttattgaag aagcaaaagc cgagggcttt gaacaaggag tagcgctggg 1695421 caaagctgag gcaatgaaac agtatgcaga actgatcggc caagcaaaca gtataactga 1695481 aatgtccaga aaagctgttg aggacaagct tgaagacgct aatgaagaaa tcgttgagct 1695541 tgccgttgcc ctagcaaaaa aagtttggca gcaaaagtct gatgataaag aggctttcct 1695601 cctgcttgta caacaggtta taaacgaagt gaaggaatat gacgatatat caatttatgt 1695661 tgatccatat tactatgaga caatctttca gcaaaaagat gaaatccagc agcttcttta 1695721 taaagaatgt cggcttggca tatatgctga tgaaaaagct caaaaaggaa cctgttatat 1695781 tgaaactcct tttggcaggg tagatgcgag tgttgacaca caattgatgc aattgaaaga 1695841 taaacttctg acagcgctgg aagcaggtgc agctgaatga agacacagag tctgatagat 1695901 tgtatagaaa tgacagactc gtataaacgg tacggaaaag tcaagcgggt aatcggcttg 1695961 atgattgaat caaaagggcc agcaagctca attggtgacc tgtgcctgat ttatgcaaaa 1696021 ggacagtctg ggaaagtcat taaagctgag gtagtcggct tccaggaaga aaatattttg 1696081 cttatgcctt atttagaggc tgcgagcatt gcacctggca gcattgtaga agctactggg 1696141 gaatcacttc gggttaaagt tgggaccgga ctgatcggac aagtcatcga tgcttttgga 1696201 gaaccgcttg acggaaagct tctgccgaaa gggctttcgc ctgtatcaac ggagcaatca 1696261 ccgcctaacc cgatgaaacg gccgcctatc cgtgaaaaga tgggtgttgg agtcagatca 1696321 attgacagct tgctgacagt cggtaaaggc cagcggattg gaatttttgc aggaagcggt 1696381 gtcggaaaaa gcaccttaat ggggatgatc gccaagcaga cagaggctga cttaaacgtc 1696441 attgcacttg tcggagaacg cggacgagag gttcgggagt ttattgaaaa agatctgggg 1696501 aaagaggggc tgaaacgatc gattgtagtc gttgccacct cagaccagcc agcattaatg 1696561 agattgaaag cggcatatac agcgactgca attgccgagt atttccgaga taaaggccaa 1696621 aatgtcatgt ttatgatgga ttctgttaca agggtggcaa tggcgcagcg agagattgga 1696681 ctggctgcag gagagcctcc gacgacaaaa ggctatacac cttcagtgtt cgctatttta 1696741 cctcgtttac tagaacgaac aggtgcaaac gagcatggaa ccattacggc attttataca 1696801 gtgttggtag atggggatga catgaatgag ccgattgccg ataccgtacg cggaatttta 1696861 gacgggcata ttgtgttgga cagggcgctt gccaataaag gccagtttcc tgcagttaac 1696921 gtactaaaaa gcatcagcag ggtgatgtca aacatttcaa caaaacagca tctggatgcg 1696981 gcaaataaat tccgtgaact tttatcgaca tatcaaaatt cggaagatct cattaatatc 1697041 ggagcttaca aaagaggatc atccagagaa attgatgaag cgatacaatt ttatccgcag 1697101 cttattcaat ttttaaagca gggaacagac gaaccggctt tattggaaga aagcattgct 1697161 gcattaacta gtttgacagg aaatgaggaa taaacgtggc ttatcaattt agattccaaa 1697221 agctgctgga actaaaagaa aatgaaaaag accaatcctt atccgaatat cagcaatcag 1697281 tttctgaatt tgaaaacgtt gctgaaaaat tatatgagaa tatgagcaaa aaggaattgc 1697341 tggaacaaaa taaggaaaag aaattaaaaa gcggcatgag tgtacaagaa atgaggcact 1697401 accaacaatt tgtctcaaat cttgataata cgatctatca ctatcaaaag cttgtcatta 1697461 tgaaaagaaa tcaaatgaat caaaaacaag aaattttgac agagaaaaac attgaagtga 1697521 aaaagtttga aaaaatgcgt gaaaaacagt ttaaaatgtt tgctcttgaa gataaagctg 1697581 cagaaatgaa agaaatggac gatatttcga ttaagcagtt tatgattcaa ggccattagg 1697641 agcgaatgta atgtccggca aaaagaaaga atcaggtaag ttccgttcgg ttttgcttat 1697701 cattatcctc ccgctgatgt ttctattaat cgcagggggg attgttcttt gggctgctgg 1697761 tatcaatgtc ttaaagccga tacaggatgc tgcggcaaaa acgccggttc ttaaagaatt 1697821 ggtccctgaa accgaaaata aaaaaggcgc agcatcaagt aaggatagca gtaatacggc 1697881 agctctggaa aagaccatta aggatcaaaa aagtgaaatc agtatattga ataaagattt 1697941 agaaacaagt aaatcagaaa tcgacaggct caatcaaaag atccgttcac ttgaaaagac 1698001 ggctgaggat caaaaaaagt catcagaaga tcatactgaa ggatcagcag actcgaaagc 1698061 ttcttctgaa aatgacaaag tgatcagtgt gtacaaaagc atggacagcg gaaaggctgc 1698121 taaaattatt gcccaattaa aggagcaaga agcactgaaa atattgaatg gcctaagcaa 1698181 aaagcagctt gctgacatat tggcgaaaat gactcctgag caagcagcaa cctatacaga 1698241 aaaaattgct gccagccaag aataggggga atgaaaggtg aagctgcttg aattagccgg 1698301 acctttgctg caaaccacaa cgggttctgc cgctaaaaac atgaaaagta gccagggagt 1698361 ttttcaaaac tggcttatgt ctgaggctgg attgaaggaa ctttcagaac aaggaaaggg 1698421 aactcctaat tctgaagatc agcttttagc agatgcgctt aaaaagatcg gtgaatggct 1698481 aaatgcaagt cctgaagatc aagacaaaca aaatgcggat cttttgcaaa cattaagcaa 1698541 actgacaggg aagcaattgg atgcgaatgc tctgcaaatg ttgcaaaatc ttttgcaagc 1698601 agttgaatca aaaatgtcag gcgggacgga tcaattgctc acagaaacgg agaaaatctt 1698661 ttcagaagct aaaacggctc tgagtgccaa tgattctgct tctgacatta atggagcact 1698721 gaagtctgat aaagagcaat caaatcagga aaatgaagta tccgagcctg caaaagagct 1698781 tatctatatc cagatgttca ttagccagct cgtagaaggg aataagctga ctgatctcgg 1698841 gaatggcaat gaagctcatg ccatttacca aaatggagat caattccttt ctgcattaga 1698901 aaagaagggt gtatctcaac aactaattca ggatcttaaa cagcaaatat tcactaaagc 1698961 tgagtcaagt tcaaaacttt actcgatgac agcgtcagag ctgaaaagtt ttcaaagctt 1699021 aatggatcaa atgtctatgc ttcctcaaaa agggaccaaa gaatggagtt tagctgaaag 1699081 ccagctgaaa gccttcttgt tatcgaaatc atccgaatca tcacaagact ttgggaagag 1699141 tgttctcaca ccgctctcgc agagttcatc cagcaaaaat gcatcggatg tttctggaag 1699201 tattcagcct gtagatagta aatcaggact ccaaatgctg ttttcggggt atcggggcat 1699261 aggaggagtt caaacacttg atctgcagca gatgtcatct gatataccaa atgccgaaac 1699321 aaaaacggtg gctgatcaag tgattaatgc gtggaagcag atgaaatata cgcctttcgg 1699381 cagatcgacg ggaagtttca ctattcggct gaaccctgaa catttaggat ttgtcacaat 1699441 caagctgaca aatgaaaatg gaatgtttca gagtaaaatc atagcatcta gccaatcagc 1699501 aaaagaattg cttgaacagc atcttcctca gctgaagcaa tcattgccga atatggccgt 1699561 ccaaattgac cgttttactc ttccggtcca aagcggggat cagccgatat acggccagct 1699621 tgctgatgaa cagaaacagc agcaagaggg gcagagacag caaagacaga aaaagcaatc 1699681 aaatgatttt ggcgatctgc tcgatgaagt gtcgatggtt gaaatggagg aagaagaatg 1699741 acttctataa gttcagaata taaactgcct gaaaaaacga acactgtgtc gacgaacaac 1699801 agcagcttgg ggaaagacga gtttttaaaa atattaatga ctcaagttca aaaccaagat 1699861 ccgcttaacc cgattgacga taaagaattt atcagccaga tggcgacttt ttcaagcttg 1699921 gagcaaatga tgaatctgaa tacgacaatg actcaattcg ttgaaaacca agatccgttt 1699981 acaacgtatg ttgattggat gggaaaagaa gtatcttgga ctgatggtaa aagtgcaaca 1700041 gataaaacag gcacagtaag ctctgttaaa cattttaaag gaaattatta tctcgttctt 1700101 gatgatggga ccgagatcag tcctgcgaat gtcatgtctg tgggacaatc atctaaataa 1700161 aaacatctgg gggaatatat tatgttacgt tcactttatt ctggaatcag cggtatgaaa 1700221 aactttcaaa caaagcttga cgtaatcggt aacaacattg ccaacgtaaa tacagtagga 1700281 ttcaaaaaga gccgtgtgac ctttaaagat atggtaagcc aaacgattgc cggcggttct 1700341 gctgctggtg caacaatcgg cggaacaaac tctaagcaaa tcggtttagg ttcatcatct 1700401 ggcacaattg atacaattca ttcaacaagc gcgacacaaa gcacaggaag aacacttgat 1700461 ttagcaattg acggcgacgg ttacttccga attgatacag gtgacgggac agcttataca 1700521 agagcaggga acttctattt agataatact ggaacactgg ttacaggtga tggctaccat 1700581 gtactaaata tgaatggcgg aacaattaaa attcctactg atgctcaaag ctttagcatt 1700641 ggttctgatg gaaaggtgtc aattgttgat gctgagggga aaacacaaga cgggggacaa 1700701 atcgggattg ttacttttgc caacagtgat ggattggata aaatcggaag caacctatac 1700761 cgtgaatctt taaactctgg aacggccagt gcagcgaacc agcctggtga cggcggaact 1700821 ggtgctctta aatcaggatt tctcgaaatg tctaacgtcg atttaactga cgaatttact 1700881 gaaatgatcg tagcccagcg cggattccaa tcaaactcaa aaattattac aacatctgat 1700941 gaaatccttc aagaactggt taaccttaaa cgttaaggag ggaggggagg cgagtaatcg 1701001 cttctccgct gttttatgat taaagtaacc cgtttgaacg ggcagccctt tacactgaat 1701061 gcgctattta ttgaacagat tgaatgtttt ccggatacta caattactct gtcaaatggt 1701121 aagaagtttg tagtaaaaga agatgaagaa gctgttctgg aaaagatcgc agctttctac 1701181 cgaaaaatac aaatatttgc aatggatcaa ggaatagagg aaccggaatg aagaaaaagt 1701241 taatgatcat attactaatt attcttatcg taattggtgc tctcggggcg gcggcttatt 1701301 ttgttttagg cggaaagtcc gaaaaaagtg aagcgaaaaa aagtattgat gaaatcgttg 1701361 cgtcttctgt tgatgtagaa gagatcacaa caaatttaaa gtctgataac attatccgtc 1701421 ttgctattaa acttgaaact gattctgata aatcaaaaga agaacttgag aaacgtgatt 1701481 tccaagtgaa agacgctgtt atatcactgc tggctgatac gaatgctgat cagattgagg 1701541 gagacaaggg aaaagaaacc tttaagaagg aactaaaaga taaaataaat agctacctcc 1701601 aagaaggaaa agtagaaaaa gtgtatatta cctcctttaa tctgcaataa agcataattt 1701661 gacagaatac ggaggtgagg aaaatgtcag gagaagttct ctcccaaaat gaaatagatg 1701721 cactgctctc tgcaatatca actggtgaaa tggacgctga agagctgaaa aaagaagaaa 1701781 aagagaagaa agtcaaggtt tatgatttca aacgtgcgct gcggttttct aaggatcaga 1701841 tccgcagttt aacgagaatt catgacaatt ttgcaagact tcttaccact catttttctg 1701901 ctcagctcag aacctatatt cacatatctg tcagttctgt tgatcaggtt ccgtatgagg 1701961 aatttatcag atcgattcca aacatgacga ttctgaatct atttgatgtt catccgatgg 1702021 aaggaagaat tatgatggag gtcaacccca cgatagctta tacgatgatg gatcgagtca 1702081 tgggcgggat tggaatcagt cataacaagg ttgacagttt gacagaaatt gaaacaaaaa 1702141 tcatttctaa tttatttgaa aatgcactgg gtaattataa agaagcttgg cagtcaattg 1702201 ctgatattga accggaaatg actgagtttg aagtgaatcc gcaatttgtt cagatggtat 1702261 ctcctaatga aacagtcgtg gtgatctcgc tcaatactca aattggtgaa atcagcggtg 1702321 tcattaatct ctgtatcccg catattgtac tcgagccgct cataccgaag ctttcagtcc 1702381 actattggat gcaatcagac cgaaatgagc caaagcctga ggaaacaaag tcgcttgaaa 1702441 aacgtatcat gacagcacaa atacctgtcg tggccgagct cggcacatct gaactgacga 1702501 tagaagagtt tttaagttta gaagtcggag actgcataac tttggacaaa tcagtcacgg 1702561 atcctcttac tgtattggtc ggagataagc cgaaattttt aggacaagcc ggccgggtga 1702621 atcgaaaaca ggcagtgcaa attttagatc acgacataag aggtgaacaa gatggagaat 1702681 aatagattat ctcaagatga gattgacgcg cttcttaacg gtactggcag cacgcttgat 1702741 gagccagaga ttccggaagt agatgactta tcggaaatgg agcgtgatgc gatcggtgaa 1702801 atcggtaata tttcattcgg cagttctgcg acagcactgt caacgctttt aaatcaaaag 1702861 gtcgatatta cgactccaag cgtaacggtc attccaagaa gtaaaatcag cgatgcgttt 1702921 cctgaaccgt atgtagcgat tgaagtgaat tatacggagg gcttcagcgg aagcaacctg 1702981 ttagtcgtgg aacaaagtga cgcggcgatc attgcggact taatgatcgg gggagacgga 1703041 aaaggtgcgg acccttcact gggtgaaatc catttaagtg cggttcaaga agcaatgaac 1703101 caaatgatgg gatcggctgc cacatcaatg tctactgtat tcagtaaaaa aattgatatt 1703161 tcacctcctc gggttgaatt gctggatgtt actgaagaaa agggtacaga ccgtattcct 1703221 gatgatgaaa tgctggtgaa agtttctttc aacttaaagg tgggagaatt aatagactcc 1703281 agcattatgc aactttaccc attgacattt gcgaaagatt taatttcaag ccttatgaac 1703341 tcagaaagtg cagaggaaga agaaacggtg cagcctgaag ttacatacga acagccgaaa 1703401 gagcctgtga cgccagagcc gcgtattgaa ccgaagcaac agcagcagcc gccaaaaagg 1703461 cagggaacag caaaaaaagc agcgccagtt caggtttcac cggtggaatt ttccgcgttt 1703521 gatccaaacg aagctgtaca agcccctatt cataatctgg atatgctttt ggatatcccg 1703581 ctttcgatta ctgttgagct tggcagaacg aagagaagcg taaaagagat tttagagctt 1703641 tctgccggaa gtattatcga gcttgataaa ttagccggtg agcctgtaga tattttagtt 1703701 aatcagcgta tcgttgccaa aggcgaggtc gttgtcattg aagaaaactt cggagtgaga 1703761 gtcactgaca ttttaagcca ggcagagcgc attaataatt taaaataacg aaacacaagg 1703821 agagagatag attatggcac atagaatttt aattgtagat gacgcagcat ttatgcgaat 1703881 gatgattaaa gatattttgg ttaaaaatgg ttttgaagtt gtggcggaag ctgaaaatgg 1703941 agcacaagcg gtagagaaat ataaagagca ttcacctgac cttgttacta tggatatcac 1704001 gatgccagaa atggatggta ttacagcatt aaaagaaatt aaacaaattg atgcgcaggc 1704061 aagaatcatc atgtgttctg ctatgggaca gcaatcaatg gttattgatg ccattcaggc 1704121 cggcgctaag gatttcattg tgaaaccttt ccaggctgac cgtgtgcttg aagcaatcaa 1704181 caaaacatta aattaaaggg tgtacgactg ttgaaaaaga gtcaatattt tattgttttt 1704241 atttgttttt tcgttttatt cagtgtacat ccgattgctg ctgccgcggc agactctgat 1704301 aattcaactg taaacgaatg gtttcaaaag aaagatgaaa aaactgcaga tcaatcagag 1704361 caaaagaaag aaaaaacaac aaaaactgct gatgagacgg agggagcggc tgctccttct 1704421 gtctcagctt ttgattttgt aaagatgatt ttcgctttac tgtttgttat cgtgctgatt 1704481 tacgggctgg ttaagctcat gaacaaaaga aatcggctcc taaagccttt tcaatatgtt 1704541 gaaaatattg gcggcacatc ggtcggtcag aacagatcca tacaattgat caaggtcggg 1704601 aaaagtgtgc tcgtcgtcgg tgtaggagag acgatccagc tgctgaaaga aattgaggat 1704661 gaaaaagaga ttgaagtcat tctcagtcag catgaagagg caatgtcaag caaaatagag 1704721 tggcaaaagt ttgtgaagcc gcttaagagt tctgaacatc agccgcagca aaaactgcct 1704781 tcattttcaa aagcattaaa agagcaactt gaagagttaa aacaaaaccg ttctgaagga 1704841 aagaagaaag gcccacgtca tcatgaatga gtttataaat attttcagtt caagcgatcc 1704901 ggaaaacgta agttcgactg ttaaattact attattgtta actgtatttt cagtggcgcc 1704961 tggaatattg attcttatga cttgttttac tcgcatcgtc attgttctgt catttgtcag 1705021 aacttcactt gcgacgcaat ctatgccccc aaaccaggtt ctaatcgggc ttgcgctgtt 1705081 tttaacattt tttattatgg ctcctacttt ttcagaaatt aataaagaag cgctgacccc 1705141 attaatggac aacaaaatca gcttggatga agcgtatacg aaagctgagg aaccgattaa 1705201 agaatttatg agtaaacaca caaggcagaa ggatctggcg ctgtttatga attacgcgaa 1705261 aatggataaa cctgaatcat taaaggatat tccgttaaca acaatggttc cggcttttgc 1705321 catatcggag cttaaaacag catttcaaat aggttttatg atttttatcc cttttttaat 1705381 tatagatatg gtagtggcga gcgtcttgat gtcaatggga atgatgatgc tgcctccagt 1705441 tatgatttct ctgcccttta aaatattact ttttgttttg gtagacggct ggtatttaat 1705501 tgtgaaatct ttgcttcaga gcttttaggg taggtgctaa acgtgagttc agaatttgta 1705561 atttctatgg cggaaaaagc cgtatacgta acgctgatga tcagcgggcc attattggct 1705621 attgctttac tggtcggttt aattgtcagc atatttcagg cgacaactca aatccaggaa 1705681 cagactttgg cgtttattcc gaaaatcgtg gcggttctcc tggctctcat tttttttggt 1705741 ccgtggatgc tgtcgacgat tctttcattt acaacagagc tgttttctaa tttaaatcgt 1705801 tttgcagggt aatgtagaga tgaattcaat tattgactta tttcctgctt ttttattggt 1705861 ttttattaga atctctgctt tttttgtaac gattccgcta tttggacatc gaaatgtgcc 1705921 agctgttcat cgcataggtt ttgctttttt tcttgcggtc atttgtttca gcaccattga 1705981 taaaccgccc tctttggaga tagatgagca ctatatgctt ttggcgttta aagaagcttt 1706041 ggtcggccta tgtctgggtt taattgctta tatgatgatt gccgcagtgc agattgccgg 1706101 ctcgtttatt gattttcaaa tgggattttc aatagcaaac gttattgatc cgcaaaccgg 1706161 tgcacaaagt ccgttgattg gccagtttat ctatacgatg gcacttttgt ttatgctgag 1706221 tgtcaatgcc caccatttgt tgctggatgg tatttactac agctttcagt atatttcagt 1706281 tgatcaggca tttccgaatt tcggcgatga aaagtttgcc tattttattg cgaaaagctt 1706341 taatgcaatg tttattatcg cttttcaaat gtcagcgccg gttgtggcca gtttgtttct 1706401 agttgattta gcattaggta tcgtggctcg aactgttccg cagttaaatg tatttgtggt 1706461 cggtctgcct ttaaagatcg ctgtcagttt cattatgctc attgtatgta tgtccgttat 1706521 cttcgtcgtt gtccggaatg ttttcagttt aacgattgaa acgatgcgga atcttttagc 1706581 attggtcggt gtttcttaat gaagcttaga gttgacctgc agttttttgc gggagagaag 1706641 acagaaaaag ccactccgaa aaaacggaag gatacgcgaa aaaaagggca ggtagccaaa 1706701 agctcggatg tcaataccgc cgtttcttta ctggtaatat tcctttcgct tattgcaatt 1706761 ggtccgtata tgagagacag gctgctgtca ttcatagaaa cattttatac cgaatcgctc 1706821 acaatgaagc tctcagaatc aaatgtgcat acattgtttg tcagcttatt aaaggatatg 1706881 ggcatgatac tcgcaccgat cttgcttgtt gctcttgttg caggagtcgt aagcaactat 1706941 atgcaggttg ggttcttgtt ttctgctgaa gtgatacagc ctaagcttga aaaactggat 1707001 ccgatcaaag gctttaaacg aatatacagt atgagggcga ttgtagagct gattaaatca 1707061 attttgaaaa tcgtagtcgt cggttttgcg gcttttgctg tgctttggct gcattatgga 1707121 gaaattctcc ggcttcctct cctgacaccc gaagaggcac tttctttcgt ttcaaaactc 1707181 actttgtgga tgggactaag cggtgcaggt gcattgttga ttcttgctgg tctcgactat 1707241 ttatatcaga gatttgacta tgagaaaaat atcaaaatgt caaaacaaga tataaaagat 1707301 gagtacaaaa aatctgaagg agacccgatt atcaagtcta aaattaaaca aagacagcgg 1707361 gaaatggcga tgaggcggat gatgcaggaa gttccaaaag cagatgtcat tatcacaaac 1707421 ccgactcact atgcgattgc tttgaaatat gatgaagaaa aaatggacgc accttatatt 1707481 gttgcaaaag gcgtcgacca ccttgcgtta aaaatcagga aaattgctaa agagcatgat 1707541 gtcatgatgg tagaaaacag accgcttgcc cgtgcgttat atgatcaagt ggaaattgac 1707601 caggcagtgc cggaagaatt ttttaaagtt ttagcagaaa ttctggctta cgtatataaa 1707661 acaaaacaaa aagtatattg aatttttcga tttaaaagga gagaaaaaac agcatgtcaa 1707721 caagagattt atccgtttta ataagtgttg tcctcattgt ggcgatgctg gtgattccat 1707781 ttcctccatg gctgttaagt attttgatca ttattaatat ttctcttgcg ttgatcgtgc 1707841 ttctcaccac aatgaatatg caggaagcgc ttcagttttc gatttttccg tcactgttgc 1707901 tgcttttgac cctatttcgt ttgggcttga acgtctcaac tacccgttca attctttcac 1707961 acggtgaggg aggtaaagtc gtcgagactt tcggaaattt cgttgtcggc ggaaatgtat 1708021 tagttggact cgttgtattt atcatcctta ttattattca gtttatcgtc attacaaaag 1708081 gtgctgaacg tgtttccgag gttgcagcaa ggtttacgct ggacgcaatg ccggggaagc 1708141 agatgagtat tgatgctgat ttaaacgcag ggatgattac cgaacaggaa gcgaagcatc 1708201 gccgcgaaaa agtggcaaga gaagcagact tttatggagc aatggacggt gccagtaaat 1708261 ttgtaaaagg tgacgccatt gccggaatca tcattgtgat gatcaatatt attttcggaa 1708321 tcgtgatcgg aatgcttcag cagggcatgt ccattcaaga agctgcttca cactttacga 1708381 tgctgactgt aggggatgga attgtttcgc aaatcccggc actgttaatt tctacggcta 1708441 cgggtattgt ggtcacaaga gctgcatctg aaggaaactt agggcatgac attacaggcc 1708501 agctgtttgc gtatccaaag cttttatacg tcgcagcagc tacgatcatg cttttaggta 1708561 ttttcactcc gatcggcatc cttctgacgg ggccgcttgc gggattgctt gcttttggcg 1708621 catatacact atctaaatca ggtaaggaaa aagaagaagt ggatgagatt cttgaggaag 1708681 aggctgaggt ggacgagctt aaaagccctg aaagtgttgt tcagcttctg catatagatc 1708741 cgatagaatt tgagtttgga tatggcctga taccgcttgc tgatgccaat caaggcggtg 1708801 atttattaga ccgaattgtt atgatacgcc gtcagttggc tttggaactc gggcttgtca 1708861 ttcctgtcgt gcgaatcaga gataatatag cgttgcagcc taatgaatac cgattgaaaa 1708921 ttaaaggaaa cgaagtagca aaaggcgagc tgttgcttga tcattattta gcgatgtcgc 1708981 ctactcctga ggacgatctc attgaaggga ttgaaacagt ggagccttca ttcggactgc 1709041 cggctaaatg gattagcgaa gcggtaaagg atgaagccga catgcttggt tatacagtag 1709101 ttgatcctgc atcagtcgtt tcaacgcata ttacggagaa aattaagcag catgcccacg 1709161 aattgatcgg aaggcaggag acaaaacagc tgatcgatca cttgaaagaa tcgtatccag 1709221 tcctggttga agaggttacg ccgaatccat tgtctgtcgg tgatattcag aaagtgcttg 1709281 ctaagctttt aaaagaaaaa gtttcaattc gaaacttagt aacgattttt gaaacacttg 1709341 ctgactatgg gaaattaaca acagattctg atctcttgac agagtataca agacaagcgc 1709401 ttgctaaaca aattacagcc cagtttgcca aagaaaatga agtgttgaag gttgttactt 1709461 gttccggccg tgtagaaaaa gcaatagcag acggtgtgca gcagacggaa cacgggaact 1709521 atttatcact tgaaccagat atttcagaaa gtatagtgcg ctctgtcgcc aaagaagctg 1709581 aacagctctc attacgtcag gaaaccgcga ttcttctttg ctcgccgcct gtcagaatgt 1709641 atgtgaagca gctactggaa cggtacttcc ctgatcttcc ggtactctct tataacgaac 1709701 ttgaggcgaa tgttgaggta caaagcattg gagtggtgga tatttaatga aaataaaaaa 1709761 atttactgct gcttcaatgc aagaagcggc acttctcatc agaaaagagt taggtaatga 1709821 agcggtcata ttaaattcga aaaaaattaa aaagcgaaaa tggtttggcc tcgtcaacaa 1709881 gcctgctgtt gaagtaatcg ccgtattgga tcaggacttt cttgagaaaa aaacgcctca 1709941 gaaggcagct gaaccgaaac aaacattaaa aactccggtc agcagtccaa aaatagagga 1710001 gagaacatat ccccctcaaa ttccggcgca acaggagcta ggtgattttt cagcatatca 1710061 atctgtactt cctgagccgc tgcgaaaagc agaaaagctt ttgcaagaaa cagggatcaa 1710121 agagtctacg aaaacgaaca ctctgaaaaa attgcttcgc ttctctgttg aagcaggcgg 1710181 cttgactgaa gaaaatgttg tcggcaaact tcaggaaata ctatgcgata tgctgccctc 1710241 agcagacaag tggcaggagc caattcattc aaaatatatc gttctctttg gttcaacagg 1710301 ggctggtaaa acaactacac tggctaaact cgcagccata tctatgcttg aaaaacataa 1710361 aaaaatcgct tttattacaa cagatacgta tcgtattgca gctgttgaac agttgaaaac 1710421 atacgctgaa ctgctgcagg ctcctctgga agtttgctat acaaaagaag aatttcagca 1710481 ggcgaaggag ctattttctg agtatgatca tgtgtttgtt gatacagctg gaagaaactt 1710541 caaagacccg caatacattg atgaactgaa agaaacgatt ccttttgaga gcagcattca 1710601 gtcatttctt gttttatccg cgactgcaaa atatgaagat atgaagcata ttgtcaaacg 1710661 gttttcatcc gtccctgtca atcagtatat ttttacgaaa atagatgaaa cgacttcctt 1710721 aggttctgta tttaatatac tggcagaatc aaaaataggt gtcgggttta tgactaacgg 1710781 ccagaatgtg cctgaggata tacagactgt atctccactt ggttttgtga ggatgctgtg 1710841 cagatgaaca gatatgacca agcagcaact ttacgggcga aaatggaaaa acgtgagcgc 1710901 gttctgccaa tggtttattc acaaaaagcg aagacacttg ctgtcatcag cggcaagggc 1710961 ggtgtcggaa aatccaatat taccttaaat atggcacttg cgctgcagga taaaggtaag 1711021 aaggtgctgc tcatcgacct tgatatcggg atggggaaca ttgatatatt aataggaaat 1711081 tcatcgtctg ccacgataat cgatgtttta accgatcgta agcctttgct gcagtcatta 1711141 tccgttggcc caaagggttt gcggtatata tcagggggaa ccggtcttga tgtgatgttt 1711201 cagctcgatc agagaaaatg gacgtttttt gccaatgaac tttctcatgc attaagccag 1711261 ttcgattatg tgctgtttga catgggagca ggcttatcaa aagatcaact gccttttatt 1711321 ttatcagcag aagatatttt gattattaca actcccgagc cgacggccat tatggacgca 1711381 tacagcgctg tcaagcactt ggttttgaca gaaaataagc tttcaatgaa ggtggctgtc 1711441 aatcggtgcc gtgaccaaaa ggaagggctt gacgcttttg cccgcctctc ccgtacaatt 1711501 catatgtttt tggatgttca ggttcagttt gccggttccg tttctgacga tgtgatcgtg 1711561 agcaaagcgg ttgtcgaaca ggttcctttt ttcataaaaa gccctcaggc aaaagccagc 1711621 cggtcagtcc gtattttagc ggacgccttg tttgaaagag aagaaacgag acacaaagaa 1711681 gacaaacaga catttattga gaaattatct tcttttttaa tgaggagggc ttaatttgat 1711741 tcgtgtgctt gtagttgatg attcagcttt tatgagaaaa atgataagtg attttctgac 1711801 cgaagaaaag cagatagaag taatcggaac tgcgagaaac ggagaagaag cgcttaagaa 1711861 gattgaatta ttaaaaccgg atgttattac tcttgatgtt gaaatgccgg tcatgaatgg 1711921 gacagatacg ctccgcaaaa ttattgagat ttataacttg ccggtcatta tggtgtctag 1711981 ccagaccgag aaaggtaaag aatgcacaat taattgtttg gagatcggtg cctttgactt 1712041 tatcacaaag ccatcaggct caatatctct ggatctatac aaaattaaag aacaactagt 1712101 tgagcgtgtc gtcgcggcag gactttccgg caagcggaaa cgtcctgttt cccagacagt 1712161 tcggcccgaa cctattgtgc gtgctgtcgt taagcctgaa ttaagcaaac cgaaacctgg 1712221 cacgggcaga caaattgtgt gtatcggcac atcaacaggc ggtccacggg cgttacaaaa 1712281 ggtgataccg aagctcccta aggatttgaa cgcaccagtg gttgtcgttc agcacatgcc 1712341 tgaagggttt actgcttctt tggctgatcg gctgaatcat ttatctgaca ttcaggtaaa 1712401 agaagcaaaa gatggtgaag cagctcttaa cggctgtgtt tacatagcac cgggcggaaa 1712461 aaacatatcc gttattaaaa acagcgaagg actccaggtt gtgcttgata accatgacac 1712521 accaagccgt cataaaccat ctgctgatta tttattccgt tctgtcggga aactgacaga 1712581 ttatgaaaaa gtagcggtta tcatgaccgg aatgggcagt gacggcactg ctggactaaa 1712641 ggacatgcta acagccggca atgtgaaagc cattgcggag tctgaagaat cttgtgtcgt 1712701 atacgggatg ccaaaagctg ctgttaaagc gggtctcatt catgagatta aacatgtgga 1712761 agatatcgca gcatccatca caagctgtgt gaaaaaagag agggtgtgat tcaaatggat 1712821 atgaatcagt atttagatgt ctttattgat gagagtaaag aacatttaca aacatgtaat 1712881 gaaaagcttc ttcttttaga gaaagacccg actgatcttc agctcgtaca tgatatattc 1712941 agggctgccc atacattaaa aggaatgagc gcaacgatgg gctacacgga tttagcacat 1713001 cttacccatc tgcttgaaaa cgtgctggat gcaatccgaa acggagacat ggaagtcacc 1713061 tcagactggc tggatatttt gtttgaagct ctggatcacc tggaaacaat ggttcagtct 1713121 attattgatg gcggggatgg taaaagagat atctcagaag tgagtgccaa gcttgatgtg 1713181 aatggtgcgc acgctgaatc cgctgcctcc gctgaacctg cagaagcaca gagttcagca 1713241 tctgattggg aatatgatga atttgaacgc acagttatac aagaagcgga ggagcaaggc 1713301 ttcaaacgat atgaaatcaa gatttctctg aacgaaaact gtatgttaaa agcagttcgt 1713361 gtctatatgg tgtttgaaaa actaaatgaa gtcggagaag tagccaaaac aattccaagt 1713421 gctgaagtgc ttgaaacaga agattttgga actgactttc aagtttgttt cttaacacat 1713481 caatcagcgg aagacattga acaattaatc aatggcgtgt cggaaattga gcatgttgaa 1713541 gtcattcaag gggctccttt aacatcagct gaaaagcctg aagaatctaa gcaagaagat 1713601 tcaccagcag cagctgtacc tgcgaagcag gagaaacaaa aacagcctgc taaaaacgat 1713661 gaacaggcga agcattcagc cggcggatct aaaacaattc gtgtcaacat tgacaggctt 1713721 gattctttaa tgaacttatt tgaagagctt gtcattgacc gcgggcgtct cgagcagatt 1713781 gcgaaagagc ttgagcataa tgaactgact gaaacggttg aacgaatgac gagaatttcc 1713841 ggagatttgc aatcgattat tctgaatatg agaatggtcc cggttgaaac tgtttttaac 1713901 agattcccga gaatgattcg ccagcttcag aaagagctga ataaaaaaat tgaactctcg 1713961 atcatcggtg cggaaactga actggatcgt acagtaattg atgaaatcgg agatccactc 1714021 gttcacttga tcagaaacag tattgaccat ggtatcgagg cgccggaaac acgtttgcaa 1714081 aagggaaaac cggaatcagg aaaagttgtg cttaaagctt atcacagcgg caaccatgtc 1714141 tttatcgaag tagaggatga cggcgcaggc cttaatcgaa aaaaaattct ggaaaaagcg 1714201 cttgagcgcg gggtcataac ggaaaaagaa gctgaaacct tagaagacaa ccaaatttac 1714261 gaattgattt ttgctccggg gttctcaact gctgaccaaa tttctgatat ttccggccgc 1714321 ggtgtaggac ttgacgttgt aaaaaacaaa ctggagtctc ttggcggttc agtcagtgtg 1714381 aaatcagccg agggtcaagg ctctctattc agcatccagc tgccgcttac cttgtctatt 1714441 atttcagttc tgctgattaa gttggaagaa gagacatttg ccattccgat ttcttcaatc 1714501 attgagacag cagttattga cagaaaagac attttgcaaa cgcatgaccg tgaagtgatt 1714561 gactttagag ggcatattgt ccctgtcgtt tatttaaaag aagagtttaa aatagaagat 1714621 acaagaaaag atgcggaaca gctccatatc attgtcgtga aaaaaggcga caaacctact 1714681 gcatttgtgg tggactcctt tattggccag caggaagttg tgctgaaatc actcggagat 1714741 tatttaacaa acgtctttgc aatttccgga gctactattt taggagacgg agaagtagcg 1714801 ctcattattg attgtaatgc actgattatt taaccattcg aggaggtgtc tcacatgact 1714861 gcagaaatta aaacaggcga aaaaatgata gtctttatgg taaatggcaa agaatatgcc 1714921 atttccgtca ctcaggtgaa atcaattgaa aaatggcaaa agccaacgag ggtacctggc 1714981 gtcgaaccat atatttgcgg ggtaatcaat ttacgcgggg tggtgactcc ggttattgat 1715041 ttaagaaaac gcctgaattt gccagagtat gaaattacag atgaaacacg aattatcatt 1715101 attgcttatc gtgatattga agtcggctgg attgtggatg aagcgaatga tgtgattacc 1715161 gtacacgaaa gtgaaataga atctgctcca gaaggcgttc agaaagatac ggatgtgtcg 1715221 atcgaacaga ttgtgaaaca agagaacaga ctcttaaata ttattgatgc gaacgcggtt 1715281 ttggataaag aatcatctca gtccgctgtg cccgatcaag cttaatctta aaggggttat 1715341 gacatgagta tttttaatgg aatcaaagaa gagcagatgg acattttgcg ggaagtcggc 1715401 aatataggcg ccggccactc cgcctctgca atggcccagc tgttaaatag aaagatagat 1715461 atggaagtcc catttgcaaa gctgctgtct tttgatgagc ttgttgattt tttcggcggc 1715521 gccgatgtcc cggttgccag catcttttta agaatggaag gcgatttaac gggttcaatg 1715581 ttctttataa tgcctttttt tcaggcggag cagtttatca gagagctgat tggaaacccc 1715641 gattttgaca tagaggactt aggtgaagac cacatgagct catccgcttt gcatgaactg 1715701 ggcaatattt tagcggggtc atatttaaca gctttggcgg atttgacgaa actccagctc 1715761 tatccaagtg ttcctgaagt ctcattggac atgttcggag ctgtgatcag cgaagggctg 1715821 atggagctca gtcaggttgg agaacacgcc attgttgtcg acacgtcaat ttttgaccaa 1715881 agccatcagc aggagctgaa agcgcatatg tttatgctgc cggactatga ttcatttgaa 1715941 aagctctttg tcgccttagg tgcatcatta tgagtacaac tgaggctgtt gttataaagg 1716001 ttgggattgc tgacgtgaag atcgcccgct tcccggatac catccggacc tctggtttgg 1716061 gctcatgtgt ggggctggtg ctttatgata aagaaaagca aacggcgggt cttgttcatg 1716121 tcatgcttcc ggattcgacg ttatcgaaaa ctgccgagct caaccgggct aagtacgctg 1716181 acaccgccgt acagaccacg attgatatgc tgatagaagc gggatgccgg aaatttgcat 1716241 taaaagcaaa gctggccggc ggatcagaga tgtttaaatt taaatcgaca aatgatttga 1716301 tgaagatcgg accgagaaat gtattagcga taaaagaaca gctgtcttta tttaatattc 1716361 ctattattag tgaagatacg ggcggctcaa gcggccggac gatagaattt gaaccgaagt 1716421 cctgcatgct gcatattcga actgttaaac aaggtgaaaa aacgatttaa ttaaggtatt 1716481 agggggataa caatgcaatc cttgaattat gaagatcagg tgctttggac gcgctggaaa 1716541 gagtggaaag atcctaaagc cggtgacgac ttaatgcgcc gttacatgcc gcttgtcaca 1716601 tatcatgtag gcagaatttc tgtcggactg ccgaaatcag tgcataaaga cgatcttatg 1716661 agccttggta tgcttggttt atatgatgcc cttgaaaaat ttgaccccag ccgggactta 1716721 aaatttgata cctacgcctc gtttagaatt cgcggcgcaa tcatagacgg gcttcgtaaa 1716781 gaagattggc tgcccagaac ctcgcgcgaa aaaacaaaaa aggttgaagc agcaattgaa 1716841 aagcttgaac agcggtatct tcggaatgta tcgcccgcgg aaattgcaga ggaactcgga 1716901 atgacggtac aggatgtcgt gtcaacaatg aatgaaggtt tttttgcaaa tctgctgtca 1716961 attgatgaaa agctccatga tcaagatgac ggggaaaaca ttcaagtcat gatcagagat 1717021 gacaaaaatg ttccgcctga agaaaagatt atgaaggatg aactgattgc acagcttgcg 1717081 gaaaaaattc acgaactctc tgaaaaagaa cagctggttg tcagtttgtt ctacaaagag 1717141 gagttgacac tgacagaaat cggacaagta ttaaatcttt ctacgtcccg catatctcag 1717201 atccattcaa aggcattatt taaattaaag aatctgctgg aaaaagtgat acaataatga 1717261 atttcatggt tagcgagtga aaaacatgtc aacactatta tggcttttaa gctttatgct 1717321 ccacggcgtt cttctgtacg ctgtcattat cctgtatacg aggctcgctg cagtgaaaga 1717381 aacagaaaaa cagcaaaaac agatacttga agagacggaa aacaccttgg cggcatttct 1717441 gcttgaatta aaagaagaaa atgagaaact gatagaaaat aaagcttcat ctgcaagtca 1717501 atcagatgaa gaatcccaaa agtcaggcct tcagacctct gaaacatatc aagagcggga 1717561 tccagtccaa gaggcagaga atcttcctga acatattgaa ggtctgatta cagaggttga 1717621 ccgtcgggaa gagctcgtaa acagtgaggt ccaatcattt gaagaccagg tcatagaatt 1717681 atatgaacag ggatattcgg caagtcaaat tgcccagaaa atgaagagcg gaaagacaga 1717741 aatcgagcta tttttaaaat ttcgctccaa aggtgtaaag gattcttgat tgtcggataa 1717801 agctgtgtta tattatgtct tggtgttaaa tacacacgct taacgattta tgcagagggt 1717861 gctgcaggcg gcagttctgt acaaaaatga cctaagcgga ggaaaaaaac cattatatta 1717921 ggaggaaata acatgtcagt catttctatg aagcaattgc ttgaagctgg tgttcacttc 1717981 ggtcaccaaa cacgccgttg gaacccaaaa atgaagcgtt acattttcac ggagcgtaac 1718041 ggaatctaca tcattgacct tcaaaaaaca gtcaaaaaag tagaggaagc ttacaacttc 1718101 actaaaaatc ttgctgctga aggcggaaaa atccttttcg tcggaacaaa aaaacaagct 1718161 caagattctg ttaaagaaga agctcaacgc tctggcatgt actatgtcaa ccaacgctgg 1718221 ttgggcggta cattaacaaa cttcgaaaca atccaaaaac gtattaaacg tcttaaagac 1718281 attgaaaaaa tgcaagaaaa cggtacgttt gatgtacttc ctaaaaaaga agtcgttcaa 1718341 ttgaaaaaag aattagagcg tcttgaaaaa ttcctaggcg gaattaaaga tatgaaggat 1718401 cttcctgatg cattattcat catcgatcct cgcaaagagc gcatcgctgt tgcggaagct 1718461 cgcaaattaa acatccctat catcggtatc gtagatacta actgtgatcc agatgaaatc 1718521 gatgttgtta tcccagcgaa cgatgacgct atccgcgctg ttaaacttct aacttctaaa 1718581 atggcagatg caatcttaga agcgaagcaa ggcgaagaag aagcggaagt tgctgaagaa 1718641 actgcaccag aaacagaaac aacaactgcg taacctattc aaaaggtgat aagagggact 1718701 gccttttatc accttttttc aagaaaaatg tgtaatatac atactcttgt ttaaacatat 1718761 aaggaggaat acaaatggca attactgcac agcaagtaaa agaactgcgt gaaaaaactg 1718821 gcgcgggcat gatggattgt aaaaaagcgt taactgaaac tgacggagat atggacaaag 1718881 caattgacct tttaagagaa aaaggaattg caaaagcagc gaaaaaagct gaccgtatcg 1718941 cagcagaagg ttctactctt attaaaactg acggcaacaa aggcgttatc ctagaagtaa 1719001 actctgaaac tgatttcgtt gcgaaaaacg aaggttttaa agagcttctt aacactttag 1719061 ctgaccacct tcttgcaaac acgccagctg atgttgaaga agcaatgggc caaaaaatgg 1719121 aaaatggctc aactgttgaa gagtacatca caagcgcagt tgctaaaatc ggtgagaaaa 1719181 tcactcttcg ccgctttaca gttcttacaa aagacgacag ctctgcattc ggtgcgtacc 1719241 ttcacatggg cggccgcatc ggtgtattaa ctgttctcaa cggtacaact gatgaagaaa 1719301 ctgcgaaaga tatcgcaatg cacgttgctg cagttaaccc tcgttacatt tctcgtgatc 1719361 aagtatctga agaagaaaca aatcatgagc gtcaaatctt aactcagcaa gccctccaag 1719421 aaggcaaacc tgaaaacatc gtagcgaaaa tggttgaagg ccgtctgaac aaattcttcg 1719481 aagaaatttg tctattagac caagcgttcg ttaaaaaccc agatgaaaaa gtgaaacaag 1719541 ttattgcagc gaaaaacgct actgttcaaa cttttgtccg ctatgaagtt ggagaaggca 1719601 tcgaaaaacg tcaagaaaac tttgctgaag aagtaatgaa ccaagtgaaa aaataatggt 1719661 gaaaagattt cgcggctaag tcgcgtcttt tcaggcagta taggggacac attttgtgtt 1719721 ccctattttt aaaactatat ttacaaacct ttttttctct tgcataatag aaaacggcaa 1719781 tgtttacact tggaggttat catggaaaaa ccaaaataca aacgtatcgt attaaagctt 1719841 agcggggaag cattggcagg agaacaggga aatggaatta acccgactgt cattcaatcc 1719901 attgcaaagc aagtgaagga aatcgctgag cttgaagtcg aagtggctgt tgttgtaggc 1719961 ggcggcaact tatggcgcgg aaaaacagga agtgacctgg gcatggaccg cgcgactgct 1720021 gactatatgg gaatgctggc gacagtaatg aattcgcttg ctcttcaaga cagcttggaa 1720081 acactcggaa tccagtccag agtgcaaaca tccattgaaa tgagacaagt tgctgaaccg 1720141 tacataagaa gaaaagcgat acgccactta gagaaaaaac gtgtcgttat tttcgctgcg 1720201 ggcacaggaa acccatattt ctcaactgat acgacagctg cactgcgggc tgctgaaatt 1720261 gaggcagacg ttattttaat ggctaaaaat aacgttgacg gtgtgtataa tgctgatcct 1720321 agaaaagatg aatcagctgt taagtatgaa tcactttctt atcttgacgt tcttaaagac 1720381 ggcctggaag tcatggattc aacagcttcc tctttatgca tggacaatga cattccgctt 1720441 atcgtctttt ctattatgga agaaggaaat atcaaacgtg ccgttatcgg tgaatcaatc 1720501 ggaacgatcg tgagggggaa ataacgtgtc aaaagaagta ttaactcaaa caaaagaaaa 1720561 aatggaaaaa gcaattgctg cttatcagcg cgaattggct actgtacgcg caggccgtgc 1720621 aaatccatca ttattagata aagtaacggt tgaatattac ggagcgcaga cacctttaaa 1720681 tcagttgtct tctattaacg tgcctgaagc tcgtatgctc gttatcacgc catacgataa 1720741 aacagcaatc ggtgatatcg aaaaagcgat tttaaaagct gatttaggtc ttacaccaac 1720801 aagtgacggc aatatgattc gaattgcaat tccggcacta acagaagaga gacggaaaga 1720861 attagtgaaa gttgtaaaaa aatatgctga agaagcaaaa gtagctgttc gtaacgttcg 1720921 ccgtgatgct aacgatgatc tcaaaaaact tgagaaaaac ggagacatta ctgaggatga 1720981 actgcgtgct tccactgaag acgttcaaaa actgacagat gaatatgtgt caaaaattga 1721041 cagtgtcaca aaagacaaag aaaaagaaat catggaagtt taatgaaaaa ctatgtacaa 1721101 tagataatag tgaaaagacc ctctcatgtt tacagggggt ttttttgtta atactgttga 1721161 ttacattgat tatcagcagg gaatgtaacc tttttgggtg acggaggaat ctcatgctca 1721221 acatactcaa aaattggaag aatcagcaaa ctgcggcttc caacttagaa cgttatacaa 1721281 aagaagacat acttaaggga gaaattcccg aacacatcgc cattatcatg gatggaaatg 1721341 gccgttgggc taaaaaacgc tctcttccca gaattgcagg ccaccatgaa gggatgaagg 1721401 tggtaaaaag gaccacgaag ctcgcaaacg aattaggtgt caaagtactg acattgtatg 1721461 cattttcaac agaaaactgg aaaagaccga aaatggaggt cgatttttta atgaagcttc 1721521 cggaagaatt tttgaatacg tatcttccag agcttgttga ggaaaatgta caggttcgga 1721581 tcattgggga tgaaacggct ttgccggcgc acacattacg tgcgattgaa aaagctgtac 1721641 aggacacggc gcaaaacgac ggaatgatcc ttaattttgc tcttaactat ggaggccgta 1721701 ctgaaattgt cagtgctgca aaatcactcg cggaaaaagt gaaggaaggc tctttgaata 1721761 ttgaagacat tgatgaatcg cttttttcta cttatttgat gactgaatct ttgcaggatc 1721821 ctgaactttt aattcgaacg agcggcgaga taaggctgag taattttatg ctatggcagg 1721881 ttgcctacag tgaatttgtc tttactgacg tcttgtggcc tgactttaaa gaagatcact 1721941 tcttgcaggc gttaggagag tttcagcaga gaggccggag gtttggcgga atttagagga 1722001 tggtggacat gaaacaaaga attttgacag gtgttctggc agcaattgta tttttatttt 1722061 tggttattgt cgggaaattg ccgttcacca tattaattta tgctatgggc agtgtggcgc 1722121 tttttgaact tttacggatg aaaaagctga agctggtttc actgccgggt ttgatcggtc 1722181 ttttattatt gtggatgttc ttattaccaa gccagtattc gttttttgaa gcggacggga 1722241 tttccaaaat ggaaatcgct ttatttgcgg tactgctatt gctgacttac acagtgttgg 1722301 tcaagaacac ctttactttt gatgaagtcg ggtttattac gcttgcagca atttacatcg 1722361 gaatgtgttt tcattatttt atcgaaatca gaaatcttga ccaatacgga ttaacataca 1722421 ttttttatgc gtgtgttgtc atttggtcca ccgattccgg tgcctatttt gtcggtaaat 1722481 cgcttgggaa gcggaaactg tggcctgaaa tcagtccgaa taaaacagtg gaagggtttg 1722541 caggcggaat tgtcatcgca cttgtattgg cgacgatttt tcagcttgtt gcacaacttc 1722601 cgatcccgta tatctatctg ctgttgatca cgctgttttt gtctgttttt ggacaactgg 1722661 gagatttagt ggaatccgcc ttgaaaagac attacgatgt aaaggattct gggaatattc 1722721 ttcccgggca tggcggtata ttagaccgtt ttgacagttt cttgtttgtc atgcctttct 1722781 tgtactttct gcttgccctt ttttcataaa aaagtctaat atgaatatga gactgatcat 1722841 gcagcaataa gaataggagt agtggcaact ttgaaaaata tttgtctttt aggagcaaca 1722901 ggatcaatcg gcgaacagac tcttgatgta ctgcgtgcac atcaagacca atttcagctg 1722961 gtatctatgt cgtttggcag aaatattgat aaggccgttc caatgattga ggtctttcag 1723021 ccgaagtttg tctctgtcgg tgatctggat acatatcata aattaaaaca aatgtctttt 1723081 tcttttgaat gccaaatcgg gctgggagaa gaaggactga tagaagcagc agtgatggag 1723141 gaggttgaca ttgttgtcaa cgctttgctt ggaagcgtcg gtcttatccc gacattaaag 1723201 gcaattgaac agaaaaaaac aattgcgctt gcaaataagg aaactcttgt cactgcaggg 1723261 catatagtaa aagaacatgc taagaaatat gatgttccgc tgctgcctgt tgacagtgag 1723321 cattcagcca tttttcaagc tcttcaaggc gaacaggcta aaaacattga acgcctcatc 1723381 attacggcat ccggcggaag ttttcgggac aagacgcggg aggagctcga atcagtaacg 1723441 gttgaagatg cattaaaaca tccaaactgg tcaatgggtg caaaaattac aattgattcg 1723501 gctacaatga tgaataaggg attagaggtg atcgaggcac actggctttt cgatatacct 1723561 tatgaacaaa ttgatgtggt tttacataag gagagcatca tccattcaat ggttgagttc 1723621 catgataaaa gtgtgatcgc acagctcgga actccggata tgagagtccc cattcaatat 1723681 gcgctcactt atcctgaccg attgccatta ccagatgcga aaaggcttga attatgggaa 1723741 atcggcagcc ttcattttga gaaagctgat tttgacaggt tccgatgctt acaatttgct 1723801 tttgaatcag gtaaaatagg aggaacaatg ccgacagtgc taaatgcggc aaacgaagta 1723861 gctgtcgctg cctttttagc tggcaagata ccgtttttgg ctattgaaga ctgtatcgaa 1723921 aaggcactaa cccgccatca attactgaaa aaaccgagcc tggcggacat tcaagaagtg 1723981 gacaaagata cccggggata cgtcaattca atactcacat aaggtggtat gttcgtgaat 1724041 acagttatag cgtttatcat tattttcgga acgctcgttt tcttccatga actgggccat 1724101 ttattgctag cccaaagagc gggaattctc tgccgtgaat ttgcgatcgg cttcggtcca 1724161 aagatttttt ctttcaaaaa aaatgaaaca gtttatacga tcaggctgct tccggtcggc 1724221 ggatttgttc gtatggccgg cgaagatccg gaaatgattg aggtgaaacc cggatacacg 1724281 gtcgggcttc tgtttaataa ggaagatcaa gttgagaaag tcatcatcaa tcaaaaggaa 1724341 aaatatccgg atgctttagt cattgaagtg gaaacagcgg atctagagca tgacatgaag 1724401 atcaccggtt atgaacaggg gaaagaggac gaactttcca gctttactgt cagcgaaaca 1724461 tcctttttta ttgtagacgg agaagaagtg cagattgcgc cgtataatcg ccaatttggt 1724521 tccaaacctg tatggcagcg gattaaagca attgctgcag ggccgattat gaactttatt 1724581 ttagcttacg tcattttagt gatgcttggg ctgattcaag gcgtaccgtc aaatgaacct 1724641 atgctcgggc agctgacaga caatggacgg gcggctgaag cagggctaaa agaaggggat 1724701 tatatccaaa gcattaacgg agagaaaatg aggtcttgga ctgacattgt ctccgctgta 1724761 aaagaaaacc cggagaaaga aatggacgtt gcagtaaaaa gagataacaa aacgcttcat 1724821 atttcggtga ctccggaagc tgttaaagat gagaacaaaa aaacaatcgg acgtttcggt 1724881 tcctatgcgc cgactgaaaa aggcgtactc tcagcggttg cttacggcgc gacatcaaca 1724941 gttgatgtca ccaaagccat tttaaccaat ctgagcaaat tagtaacagg ccaatttaaa 1725001 ctcgatatgc tgtcaggtcc tgtcggcata tatgacatga cagaccaagt ggcgaaaaca 1725061 gggatcgtga acttatttca gtttgcggcg tttttaagca ttaaccttgg gattgtcaac 1725121 ctgcttccga ttccggcact tgacggagga agactgttgt ttctatttat tgaagcgatt 1725181 cggggcaaac cgattaacag ggaaaaagaa gcatttgttg tgtttatcgg agtagctttc 1725241 ttaatgcttc ttatgctggt tgtcacatgg aacgatatcc agcggctgtt tttgtaaacg 1725301 aaaagtaaat caatcagagg tgcgaagaaa tgagacaaag cttgacgctt attcctacgc 1725361 tccgtgaagt tccagctgat gccgaagcaa aaagtcatca gcttcttctg agagcaggat 1725421 ttatcagaca gaatacgagc ggggtataca gctatatgcc tcttgcgtat aaggtgattc 1725481 aaaacattca gcagattgtt cgagaggaaa tggagaaaat tgatgccgta gaaatgctca 1725541 tgcccgcatt gcagcaggca gagacatggc aggaatcagg cagatggtat acgtatggtc 1725601 ccgaactgat gagactaaaa gaccgtcatg gccgtgaatt tgctttaggg gcaacgcatg 1725661 aagaggttat cacttcgctt gttcgcgatg aggttaaatc ttataagcgt ctccctctga 1725721 ctctttatca aattcagtct aagttcagag atgaaaaacg tcctcgcttc ggtttgttaa 1725781 gaggccgcga atttattatg aaggatgcgt actctttcca tgcatctgca gagagcctgg 1725841 atgaaacgta tcaaaaaatg tacgaggcct attctaatat ttttgcccgc tgcggcatta 1725901 atgtaagacc tgttatcgct gattcaggcg caatgggagg aaaggatacg cacgaattta 1725961 tggcactttc tgcgatcgga gaggatacga ttgcgtattc tgatgaatca cagtacgcgg 1726021 ctaatatcga gatggctgaa gttcttcacc aggaagttcc ttcagatgaa gagcctaaag 1726081 ctctagagaa ggttcatacg cctaacgtga aaacaatcga agaactgact gcgttcttac 1726141 aggtttcggc tgaagcgtgc attaagtcag tattgtttaa agctgatgac cgttttgtct 1726201 tagtgcttgt aagaggggat catgaagtta acgatattaa agtgaaaaac ttgcttcatg 1726261 cagaagttgt agagcttgct acacatgaag aggtcattca gcagctcgga acagagccag 1726321 gctttgtagg ccctgtcggt attcatcagg atgtggaagt atatgccgat caagctgtga 1726381 aagcaatggt taatgctgtt gccggggcaa atgaaggaga tcatcattat aaaaatgtca 1726441 atgtgaatcg tgacgcgcaa attaaagaat ttgctgatct tcgttttatt aaagaaggtg 1726501 atccttcacc agacggcaag ggaacgatcc gttttgctga gggaatcgaa gtcggacaag 1726561 tctttaagct cggaacacgc tattcagaag cgatgaatgc gacatattta gatgaaaacg 1726621 gacgcgcgca gccaatgctg atgggctgtt acggaatcgg tgtgtcaaga acgctttctg 1726681 ctattgctga acagcatcac gacgaaaaag gcttaatatg gccaaaaagc gttgcgccgt 1726741 acgatcttca tattcttgct ttgaacatga aaaacgatgg gcaaagagag cttgctgaaa 1726801 agctgtatgc cgatttaaaa gcggaaggct atgaagtgct ctatgatgac cgtgctgagc 1726861 gtgccggcgt aaaattcgct gattcagatt taatcggcct tccaatccgc atcactgtcg 1726921 gaaaacgagc tgacgaagga atcgtcgaag tgaaaattcg tcaaactggt gagtcaactg 1726981 agatttcagt agacgaatta tctgcgttta tcagcaagca gtaatcacca taacgattta 1727041 tcaaaaaaca tgttaaaata gaaataatag aaggtacctc attgcctgag gtaccttcac 1727101 ttatgatgtt tttagggagg gatactgtct taatggaaca gttatcagta aacagaaggc 1727161 agtttcaaat tcttctgcag cagattaata tgacagatga taccttcatg acatactttg 1727221 aacatggcga gattaaaaag ctgacaattc acaaagcttc taagtcttgg cattttcatt 1727281 ttcaatttaa atctttgctg ccttttcaaa tatatgacac attaacaacg aggctgacgc 1727341 aatcgtttgc ccacatagca aaagtgacat cttcaattga agttcaggat gccgaggtca 1727401 gtgaaagtat cgttcaagac tactggtcac gctgcattga agaactgcag ggcatttcgc 1727461 cgccgattat cagtctttta aaccagcaaa aaccgaagct gaagggcaat aaactgattg 1727521 tcaaaaccaa aacagataca gaagcggctg cgctaaagaa caaatacagt tccatgattc 1727581 aagcagaata ccgtcaattt ggctttccgg atcttcagct tgatgctgaa atatttgtat 1727641 ccgagcaaga agttcaaaag tttcgggagc aaaagcttgc ggaagaccaa gagcgggcta 1727701 tgcaggcctt gattgaaatg gagaagaaag ataaagaaag tgatgaagac caagcaccat 1727761 ctggtcctct tgttatcggt tatcaaatta aagataacga ggaaatccga acacttgaca 1727821 gcatcatgga cgaagaacgg agaattacgg tccaaggtta tgtgtttgat gtggagacgc 1727881 gcgagctgaa gagcgggcgc acgctgtgta tcttcaaaat tacagactat acaaatagta 1727941 ttttgatcaa aatgtttgca cgtgaaaaag aagatgcggc gctgatgaag tctctgaaaa 1728001 aaggaatgtg ggtaaaagca cgcggaagca ttcaaaatga tacatttgtc agagaccttg 1728061 tcatgatcgc aaatgacgta aacgaaataa aagcaaaaac ccgtgaagat tcagcacctg 1728121 aaggagaaaa aagagtggaa ttgcatcttc attccccaat gagccaaatg gatgctgtta 1728181 cgggtatcgg aaagcttgtc gaacaggcga aaaaatgggg gcatgaggcc atcgctttga 1728241 ccgaccatgc tgtcgttcaa tccttccctg atgcgtattc tgcggccaaa aagcatggaa 1728301 ttaaaatgat ttacgggatg gaagcgaatc tcgtggatga tggcgtgcca attgcttata 1728361 atgccgcaca tcgtctgctc gaagaagaaa catatgttgt ttttgacgtt gagacgacag 1728421 gattgtctgc tgtatacgat accattattg agctggctgc agtaaaagta aaaggcggag 1728481 aaattattga taaatttgag gcgtttgcga acccgcatcg tccgctttcc gccacaatca 1728541 tagagctgac agggatcaca gatgatatgc tacaagacgc tccggatgtc gtagatgtaa 1728601 taagagattt cagagaatgg attggcgatg atattcttgt cgctcataat gcaagctttg 1728661 atatgggatt cttaaatgta gcctataaaa aacttcttga agtcgaaaaa gctaaaaacc 1728721 cagtcattga tacgcttgaa cttggacgtt ttctctatcc ggaatttaag aaccaccggt 1728781 tgaacacact ttgtaaaaag tttgatatcg agctcacaca gcatcaccgt gcgatctatg 1728841 atactgaggc aaccgcttat ttgcttctga aaatgctgaa agacgcagct gaaaaaggta 1728901 ttcagtacca tgatgagttg aatgaaaata tgggtcagtc caatgcttat caaagatcaa 1728961 gaccgtatca tgcaacatta cttgccgtga acagcacggg acttaaaaat ttatttaagc 1729021 ttgtgtcact ttctcatatt cattattttt acagagtgcc gcgtattccg agatctcagc 1729081 ttgagaaata cagggaaggg cttctgatcg gttctgcttg tgacagggga gaggtttttg 1729141 agggaatgat gcaaaaatcg cctgaagagg tggaagatat cgcgtcattc tatgattacc 1729201 ttgaggttca gccgcctgaa gtgtatcgtc acttgctgga gcttgaactg gtccgtgatg 1729261 aaaaagcgct gaaagaaatt attgcgaata tcacgaagct gggggaaaag cttaataaac 1729321 cggttgttgc tacgggaaat gttcattact tgaatgatga ggataaaatc tacagaaaga 1729381 ttttaatatc ctcacaaggc ggggcaaatc cgctgaatag gcatgaactg ccgaaagtgc 1729441 atttcagaac gacagacgaa atgcttgaag ctttttcttt cttaggtgaa gaaaaagcga 1729501 aggagatcgt agtcaccaat acccaaaagg ttgcttcttt agttgatgac atcaagccga 1729561 ttaaagatga tttatatacg ccgaaaatcg aaggcgctga tgaagagatc agagaaatga 1729621 gctatcagcg tgcaagaagc atttacgggg aagagctgcc tgaaattgtc gaagcgcgga 1729681 ttgaaaaaga gttaaagagt attattggcc acggatttgc tgttatttac ttgatctctc 1729741 acaaacttgt aaaacgttca ctagatgacg ggtatctcgt tggttcccgt ggttccgtag 1729801 gatcttcatt agttgcgaca cttactgaga ttactgaggt aaacccgctg ccgccgcact 1729861 atgtttgtcc tgagtgccag cattctgagt tctttaatga cggttctgtc ggttctggtt 1729921 ttgacctgcc tgacaagaca tgccctcatt gcggaacgcc tttgaaaaaa gacggccatg 1729981 atattccatt tgaaacgttc ttaggattta aaggggacaa agtacctgat atcgatttga 1730041 acttctcagg ggaatatcag ccgcaagcac acaattacac aaaagtattg ttcggagaag 1730101 acaatgtata tcgtgcggga acaataggca cggtggcaga aaaaacagcc tacggttatg 1730161 taaaaggcta tgccggagac aacaatcttc atatgcgcgg tgccgaaata gatcggctcg 1730221 tacagggatg cacaggtgta aaacgtacaa ctggacagca ccctggcggt attatcgtag 1730281 ttccggatta tatggatatt tatgattttt caccgatcca gttcccggca gatgccacag 1730341 gttcagagtg gaaaacgact cattttgatt tccactccat ccatgacaac ctgttaaaac 1730401 ttgatattct cggacacgat gacccgactg ttattcggat gcttcaagac ttaagcggaa 1730461 tagatccgaa aacaattccg acggatgatc ctgaagtgat gaagatcttc cagggaaccg 1730521 aatcactcgg tgtgactgaa gaacagattg gctgtaaaac gggcactctt ggaattcctg 1730581 aattcggaac ccgatttgtc cggcagatgc ttgaagatac aaagccgacc actttttctg 1730641 agctcgttca gatttcaggc ttgtctcacg gaactgatgt atggcttggc aatgcacagg 1730701 agctcatcca caataatatt tgtgagctga gtgaggttat cggctgccgt gatgacatta 1730761 tggtttattt aatctatcaa ggccttgagc cgtcccttgc ctttaaaatc atggaattcg 1730821 tgcgtaaagg aaaaggatta acgcctgaat gggaagaaga aatgaaaaat aacaatgtcc 1730881 cagactggta tattgattcc tgtaaaaaga ttaaatacat gttcccgaaa gcccacgccg 1730941 cggcatatgt cttaatggca gtccgcattg cttactttaa agtgcatcat gctcttttgt 1731001 attatgcggc ttattttacc gttcgtgcag atgactttga tattgataca atgatcaagg 1731061 gctctacagc aatcagagcg gtaatggagg atataaacgc taaaggactt gatgcttcac 1731121 cgaaggaaaa gaaccttctg actgttttag aattagcgct tgagatgtgt gagagaggct 1731181 attcattcca aaaagtcgat ttatatcgct ccagcgccac agagtttatt attgacggca 1731241 acagtcttat tccgccgttt aactctattc cagggttagg gacgaacgct gctttgaaca 1731301 ttgtaaaagc tcgcgaagaa ggcgaattcc tctcaaaaga agatttgcaa aagagaggga 1731361 aagtatcaaa aacgatttta gagtacttag atcgccatgg ctgtctggag tcactgcctg 1731421 atcaaaacca attgtcactg ttctaatatg gaaagcagaa tttctcagaa attctgcttc 1731481 tatgcataca taagcgcaaa aagtgccatc gtaatattag agtttctgtc acttgcttag 1731541 gtatgaaggt aagcgtatat ccatttgcaa taaaaatatg gttatggtat agttttattg 1731601 gaaatgctaa cgattaccga ggcaaagagt ggggaaaccc gctcttttgt attgaacagg 1731661 agaattttgt ctcgacatgt tcatcgttta ctttttagcc cctgctcttt tgaagcaggg 1731721 tttttatgca gagtgacgag acgaatatga gatcgacagc acaaggagga agaacatgag 1731781 caaaaaagtg actgacaccg ttcaagaaat ggctcagcca atcgtagaca gccttcagct 1731841 ggaactcgtt gacattgaat ttgtcaaaga gggccaaagc tggttccttc gcgtgtttat 1731901 tgattccgat gacggtgtgg atattgagga atgtgccaaa gtaagcgaag ctttaagcga 1731961 aaagcttgat gaggcagacc caatcagcca aaattacttt cttgaagtct catctccagg 1732021 agctgagcgt ccgctaaaga aaaaagccga tttcgaaaaa tcactaggaa aaaacgtata 1732081 cattaagacg tatgagccta ttgacggcgt aaaagtgttt gaaggtgaac tggctgaatt 1732141 tgatggacaa acagtgacag ttgagatcac gatcaaaaca agaaagaaac ggatcaatat 1732201 tccgtatgaa aagatagcta atgcaagatt agctgttaca ttctaatgaa tacaaatgtt 1732261 ttaagggggg agaccgttaa atgagcagtg aattattaga tgctctcacg attcttgaaa 1732321 aagaaaaagg catcagtaaa gaaattatca tcgaagcaat cgaagctgcg ttaatttctg 1732381 cttataagcg gaattttaat caagcgcaaa atgtacgggt ggatctaaac cgtgaaactg 1732441 gctccatccg tgtatttgca agaaaagatg tcgttgacga agtatacgac cagagattag 1732501 aaatctcaat tgaagaggca cagggcatcc atccggaata tatggtcggc gatgtcgtcg 1732561 aaatcgaagt tacacctaag gatttcgggc gcatagctgc tcaaacagcg aagcaggtcg 1732621 tcacacagcg tgtgcgcgaa gctgagcgcg gtgtgattta ttctgaattt atcgaccgtg 1732681 aagaagacat catgacaggg atcgtccagc gtctggacaa taaatttatc tacgtgtctt 1732741 taggcaaaat agaagccttg ctgccggtta atgagcaaat gccgaatgaa agctacaagc 1732801 cccatgaccg cattaaggta tatatcacaa aagtagaaaa aacaacgaag ggtccgcaga 1732861 tttatgtgtc aagaacacat ccaggcctgt taaagcgttt gtttgaaatt gaagtgcctg 1732921 aaatttatga tggaactgtc gagctaaaat ctgttgccag agaagccggc gaccgttcga 1732981 aaatttctgt tcgcacagat gatcctgacg ttgatcctgt cggttcatgc gtagggccta 1733041 aaggccagcg tgtgcaagca atcgtcaatg aattaaaagg tgaaaaaatt gacattgtca 1733101 actggtccag tgatcctgta gaatttgtcg cgaatgcgct cagcccttcc aaagtgcttg 1733161 atgtcattgt taatgaagaa gaaaaagcga caactgttat tgttcctgat taccagctgt 1733221 ctctggcaat tggaaaaaga ggacaaaacg cacgcttagc tgctaaactg acaggctgga 1733281 agattgatat taagagcgaa acggacgcaa gagaacttgg aatctatccg agagaacttg 1733341 aagaagatga tgagccgctc tttacggagc ctgaaactgc tgaatcggat gaataagagg 1733401 tgactttagg tgaataaaca caaaaagatc ccattacgca aatgtgtagt gactggtgaa 1733461 atgaagccta aaaaggaact gatccgagtt gtacggtcga aagaaggcga aatctcagta 1733521 gacccgaccg gaaaaaagaa tgggcggggt gcttatttaa cgctggataa agagtgcatc 1733581 ttagcagcaa aaaagaaaaa cactttgcaa aatcaatttc aatcacaaat cgatgaccag 1733641 attttcgatg aattgctgga actggcggaa aaggtgaaaa aataaaatgt ctggaatgga 1733701 atggtttccc ttgctgggtc tggccaatcg agctcgtaag gtcgtgtcag gcgaagactt 1733761 ggtaataaaa gaaatcagga atgcgcgtgc aaagcttgtc ctgcttacag aggatgcatc 1733821 atctaacaca gcaaaaaaag taactgacaa gtgcaattat tataaagtcc cttataaaaa 1733881 agtcgagagt cgcgcggttc ttggacgctc tatcggtaaa gaagcccgtg tcgttgtcgc 1733941 cgtcactgac caaggttttg cgaataagct gatcagcttg ctcgattaat atttttgggg 1734001 gtgaacgaat ggctaaaatg agagtatacg aatatgcaaa agcgttaaat gtttcaagta 1734061 aggaaatttt gaccgcactg aagaacatgg atttagaagt gaataatcac atggccatgc 1734121 ttgaagaaaa ggccattaaa aagctagatg ccaaatataa aaaaggcggc gcagctgcta 1734181 aatctcaaaa gccagcagaa acgaacaaaa acaaacagcc acaaggggtt aatcagcaat 1734241 cagctggaaa tcaaccaaat aaaattcgag acggaaagaa gaatgacgtg cagaataatc 1734301 aatttaacaa aaacaagaag aataacaaca acaaaaaaaa taaacgcaac aacaacaata 1734361 ataaaaacca acatcagcaa aagcctgtaa agccgaaaaa agagcttcct gagaaaatta 1734421 cattctctgg cactttaaca gttggcgcac ttgctgaaga gcttggcaaa gagccttcag 1734481 aactcattaa aaagctgatg cttcttggcg taatggcaac cattaaccaa gagcttgata 1734541 aagacacaat cgaactcatt gcatcagaat atggtgttga aacagaagag gtcattgtgc 1734601 ttgaagaaac agagctggaa aaatacgaag agcctgataa tgaagaggat cttgaaattc 1734661 gtcctcctgt cgtgacaatc atgggccacg ttgaccatgg gaaaacaacg cttcttgaca 1734721 gcatccgtaa aacaaaggtt gttgaagggg aagcaggcgg aatcactcag catatcggcg 1734781 cttatcaaat tgaagagaac ggcaagaaaa tcacgttctt ggatacaccg ggccacgccg 1734841 catttacaac aatgcgcgca cgcggtgcag aagtaactga tattacgatt cttgtcgtag 1734901 ctgccgatga cggtgtcatg ccgcaaacag ttgaagcgat taaccatgca aaagcagcag 1734961 aggttccaat catcgttgct gtgaataaaa tagataaaga atccgcaaac cctgaccgtg 1735021 taatgcaaga actgacggaa tacggacttg tccctgaagc ttggggcgga gaaaccattt 1735081 ttgtgccgct ttccgcttta actggaaaag gcattgatga gctcgttgaa atgattttgc 1735141 ttgtcagtga ggtagaggaa ctgaaagcga atccgaatcg tcaggcaaaa ggaacggtta 1735201 ttgaagctga actcgataaa ggcagagggt cagtcgcgac gttgctcgta cagactggaa 1735261 cactgcatgt cggtgatccg atcgtagtcg gcaatacatt tggccgtgtc cgtgcaatgg 1735321 tcaacgacat tggccgccgt gtgaaaactg ccggcccgtc aactccggtt gaaattaccg 1735381 gtttgaatga tgtccctcaa gcgggagacc aattccttgt ctttaaggat gaaaaaacag 1735441 ctcgttctgt cggtgaagcc cgtgcttcga aacagcttga agagcagcgc agcgataaag 1735501 cgaagctcag tcttgatgat ttatttgagc aaattaagca aggtgatgta aaagacatca 1735561 acctcatcgt aaaagctgac gttcaaggat ctgctgaagc tttaacggct gcacttcaaa 1735621 aaattgaagt agaaggcgtt aaagtgaaaa tcatccatac aggcgttggt gcgattactg 1735681 aatcagacat tatcttggca tctgcttcca atgcaattgt tatcgggttt aatgtgagac 1735741 cggacggaaa tgctaagagt acggctgaag ctgaaaatgt agatattcga cttcaccgta 1735801 tcatttacaa agtaatcgac gagattgaag ctgccatgaa aggtatgctt gatcctgaat 1735861 atgaagaaaa agtaattggt caagtagaag tacgccaaac attcaaagta tctaaaatcg 1735921 gtacaattgc cggcggatat gttactgaag gaaccattac gcgcgacagc ggcctccgtt 1735981 taattcgtga cggcgtcgtc atctttgaag gcgaagtaga tgttctgaaa cgctttaaag 1736041 acgatgtgaa agaagtttca caaggctatg aatgtggtat tacaattaag aaatacaatg 1736101 acattcgtga aggtgacatc cttgaagcgt ttgtcatgca agaaattgaa agaacgtgat 1736161 cggatttgcg gagtgtgaat gcatcattta tgatgcagga tcgctaaaag aaaagcgtgc 1736221 cgttctgaag cggattttaa ccagggttca aaacaagttc aatgtttcga tttcggagat 1736281 tggctatcag gacacctggc aaagaaccag cttcggaatc gccgctgttt cttcctctcg 1736341 cgttcaaaca gaaaaagaac tgcagcgcgt cctagcgttt atcgattctt ttcctgaaat 1736401 tgaacggacg atcactagga cagagtggtt ttaacttaga ggtgattgaa ttgagtatga 1736461 gagcaaaccg tgtcggcgag caaatgaaaa aagaactcgg tgatattatc agccgcaagc 1736521 tgaaagaccc gagaattggt tttctgacag taacggatgt acgtgtatca ggtgatttgc 1736581 aaattgcaaa ggtgtatatc tcggttctcg gtgacgagaa aaaacgggaa gaagcgctga 1736641 aagggctggc aaaagcgaaa ggatttatcc gatccgaaat cggcagccgc atcagacttc 1736701 gaaaaacgcc tgaaattgaa tttgagttcg atgaatcaat cgattacggg aatcggatcg 1736761 aaacactgat tcacgaatta cattcagaga aaccatctga ataaaaaaag agaggatagg 1736821 cgtatatcgt ctgtcctctt tcttcgttta taagaaaaaa actcaaaaga aggagtgaaa 1736881 ggcaaatggt taacggagtt ctccttttac ataaacctgt tggcatgaca tcgcacgact 1736941 gtgtcatgaa gatccgaaag ctgttaaaaa caaaaaaagt aggacataca ggaacgctcg 1737001 atccggaagt atcaggcgtg cttccgattt gtgtaggaag agcgacaaaa atagtcgaat 1737061 acttaactga aaaatctaaa acgtatgatg cagaaataac attgggcttt tcaaccacaa 1737121 cagaggatca aaccggagaa acggtggaaa caaagcctgt caatcacgac attgataaag 1737181 cggatgtaga aaaggtttta aacagtttaa aggggaaaca agaacaaatt ccgcccatgt 1737241 attccgctgt aaaagtaaac ggcaaaaaat tatacgaata cgcaagagca gggattgaag 1737301 tagaacgtcc gaaacgtatg ataaccattg aagacattgc cctgacaaca gagattaaac 1737361 atcatggaga aaccgcaagc ttccggttta cagtgacttg ctccaaaggg acctatgtaa 1737421 ggacgctggc ggtcatgatc ggagaaaagc tcggatatcc ggcccatatg tctcatttaa 1737481 tccgtacggc atccggagat ttttctctcg acgaatgctt tacttttgat gaactcgaag 1737541 cacaggccca atccggaacc gtggaagagc atacagttcc tattgaacgt gcgctcaatc 1737601 atttgccgaa atggatcata agtgatacat tagctaagaa agtagaaaat ggggctttgc 1737661 ttgagacgcc cgagcagttt tctgaaatga caagtggaga ccgtattgcc gtctttactg 1737721 aatccggaac ctgcttggcg atctatttcc ctcatcctgc aaaaaaaggg ctgttaaagc 1737781 cggcaaaagt attgatgcaa aaaagcgaac aatagaaaaa aggtgaccgt tctgtgaaga 1737841 cgatacatat tacacatcct catcatttaa taaaagagga gcaggcaaaa tcagtgatgg 1737901 cgttaggtta ttttgacggc gttcatctcg ggcatcaaaa ggtaatcggc acagcgaagc 1737961 aaatagccga agaaaaaggt ctgacattag ctgtgatgac ctttcatccc catccttctc 1738021 acgtgttggg cagagataag gaaccaaagg atctgattac gcctcttgaa gacaaaataa 1738081 accaaattga acaattaggc acagaagttc tgtatgtcgt taaatttaat gaagtgtttg 1738141 cttctctttc tcctaagcag tttatagacc agtatattat cggccttaat gtgcagcacg 1738201 cagtggcagg ctttgacttt acgtacggca aatacggcaa gggaacaatg aagaccatgc 1738261 cggatgattt agacggaaaa gctgggtgca caatggtaga aaaattaacg gagcaggata 1738321 aaaaaatcag ttcttcgtat atccgtaccg cgcttcaaaa cggagatgtt gaattggcga 1738381 atgtcttgct tggacaacct tattttatta aaggaattgt cattcatggt gataaaagag 1738441 ggcggaccat cgggtttccg acagcgaatg tcggtttaaa taacagctat atcgttccgc 1738501 ccacaggtgt atatgccgta aaagcggaag tgaacggcga agtttacaat ggcgtttgca 1738561 atattggcta taagccaacg ttttatgaaa agcgccctga acagccttcc atcgaggtca 1738621 atctgtttga tttcaatcaa gaggtatatg gagccgctat aaaaatcgaa tggtacaaac 1738681 ggattcggag cgagcggaaa ttcaatggca tcaaagaatt aactgagcaa attgagaaag 1738741 ataagcagga agccatccgt tatttcagca atttgcggaa ataacttgca acgcacgcaa 1738801 attttattct aaaatatttg catataggca cgatttttag tatgatagtt ttcgtagtct 1738861 taaaaccatt gcttggcaat ccgaagtcac cgacggttgc taggtaactg gggctaaata 1738921 tgatttggag gtgaaacagg atggcaatta ctcaagagcg taaaaaccaa ctcatcaatg 1738981 agttcaaaac acacgaatct gatactggat ctccagaagt tcagatcgct atcctaactg 1739041 actcaattaa caacttgaac gagcatttac gtactcacaa gaaagaccac cactcacgtc 1739101 gcggtcttct taaaatggta ggtaagcgtc gtaatcttct tacgtatctg cgtaataaag 1739161 acgtaactcg ttaccgtgag ttaattaaca aactaggctt acgtcgataa tcgtaaaaag 1739221 cgggaggatt cccgcttttt tatcgtatta aagcgaaatt tcttataaca aatcattgaa 1739281 atccttttac atactacttt gacattgata tgttcaattc atttcgttca taataggagt 1739341 aattgattat ttcacacaac gaagagagga gttcgtaatt gtatgggaca agaaaaacat 1739401 gtctttacca tagattgggc cggaagaacg cttaccgttg aaaccggcca gcttgccaaa 1739461 caggcaaatg gtgctgtgat gatccgctac ggtgatacag cagtacttag tacagcaacc 1739521 gcttcaaaag aacctaaacc gcttgatttc ttccctctta ctgtaaacta tgaagaaaga 1739581 ttatatgcgg tagggaaaat tccgggcgga tttattaaaa gagaaggacg tccaagtgaa 1739641 aaagcggttc ttgccagccg tttaattgac cgtccgatcc gtcctttgtt tgccgatgga 1739701 ttccgtaatg aagttcaagt catcagcatt gtcatgagtg ttgaccaaaa ctgctcttca 1739761 gaaatggctg ccatgttcgg ttcatctctt gcactttctg tatcggatat tccgtttgaa 1739821 ggaccgattg caggggttac tgtcggacgc attgatgatc aatttatcat taacccgaca 1739881 gtcgatcagc ttgaaaaaag cgatatcaat cttgtcgttg ccggcacgaa agatgcgatt 1739941 aacatggtag aagcgggagc ggacgaagtt cctgaggaaa tcatgcttga ggccattatg 1740001 ttcggccatg aagagattaa acgcctgatt gcattccaag aagaaattgt tgcagcagtc 1740061 ggcaaagaga aatctgaaat taagctcttt gaaattgatg aagagcttaa tgaaaaagta 1740121 aaagctttgg cagaagagga tctgctgaaa gccatccaag ttcatgaaaa gcatgcccgt 1740181 gaagatgcca ttaacgaagt gaagaacgca gttgtggcaa aattcgagga tgaagaacat 1740241 gatgaagaca caatcaagca agtgaagcag attttatcca agcttgtgaa aaatgaagtt 1740301 cgccgcctga ttactgaaga gaaagtaaga ccggacggcc gcggtgtcga tcaaatccgt 1740361 ccgctctctt cagaggttgg cctcttgcca agaacgcacg gttcaggtct atttacaagg 1740421 ggacaaactc aggccctcag cgtatgtacg ctaggtgctc tgggagatgt gcaaatcctt 1740481 gacggcttag gtgtcgaaga gtcgaaacgg tttatgcatc attacaactt cccgcaattc 1740541 agcgttgggg aaacaggacc gatgcgcgga ccgggacgtc gtgaaatcgg acacggagca 1740601 ctgggtgagc gtgcgcttga gccagttatt ccgtctgaaa aagacttccc ttatactgtc 1740661 cgtcttgttt cagaagtgct tgaatcaaac ggttctacat ctcaagcaag catttgcgca 1740721 agcacacttg caatgatgga tgccggtgta ccgattaaag cgccagttgc tggtattgcg 1740781 atgggtcttg tcaaatcagg cgaacattac actgtcttga ctgacatcca aggcatggaa 1740841 gacgcgctcg gagatatgga ctttaaagta gcgggaactg aaaaaggcgt aacggccctg 1740901 caaatggaca ttaaaattga aggcctttcc agagagattc ttgaagaagc gcttcagcag 1740961 gcgaaaaagg gcagaatgga aatcctcaac agcatgcttg caacattaag cgaatcaaga 1741021 aaagagcttt ctcgatatgc gcctaagatc ttaacaatga ccattaatcc tgataaaatc 1741081 cgcgatgtca tcggaccaag cgggaaacaa atcaataaga tcatcgaaga aaccggtgtt 1741141 aaaattgata ttgagcagga cggcacaatc tttatttcct ctacagatga aagcggcaac 1741201 caaaaagcga aaaaaatcat cgaagacctt gtgagagagg ttgaagtcgg ccaactttac 1741261 ctaggtaaag tgaaacggat tgaaaaattc ggggctttcg ttgaaatttt cagcggaaaa 1741321 gacggtttgg tgcacatttc agagcttgcg cttgaacgcg tagggaaagt tgaagatgtt 1741381 gtgaaaatcg gagacgagat tcttgtcaaa gtcactgaaa ttgataaaca aggacgagtg 1741441 aatttatccc gcaaagcggt gctccgtgaa gagaaagaaa aagaagaaca acaatcttaa 1741501 atgaaaacat aaaaggagcc tgggagaccc ggcttcttta ttttgaagct tttcaaaagc 1741561 aggcgggttc taccttgtcc ttctccttca taatgtgagg tgaggggggg acagaacatg 1741621 tacaaaaaat ttgtaccgtt tgccgttttt ttatttcttt tttttgtctc atttgagatg 1741681 atggaaaatc cgcatgcact tgattatata ggggcaatga aaaaagatac ggtgactgtc 1741741 acggcgtcaa aagacccgtt atatgaagaa ttgcttcaaa aagcgccgga gtacgaagtt 1741801 aagccccaga atgcaagaat tgataaagtg tggaaaagca ttccaggcta caatggatta 1741861 aaggtcaata ttgaacaatc atataaaaaa atgaaacagc atggtaagtt tcgggaaaaa 1741921 gatttggtgt acagtcaagt aaaaccaagt gttcatcttg agtcacttca gcctgagcct 1741981 atttataaag gaaatcctga caaaccgatg gtggcttttt taatcaatgt ggcatgggga 1742041 aatgagtatt tggaaaaaat gcttcctatt ctgcaaaagc accaggttaa agctacgttc 1742101 tttttagaag gcaattgggt gagaaacaat gtacagctcg ctaagaagat tgcaaaagac 1742161 ggacatgaaa tcggaaatca ttcatacaat catccggata tgagcaaact gactacagga 1742221 agaatttccg agcagctcga caagactaat gaacaaatag aacaaacgat cggcgttaag 1742281 ccaaagtggt tcgctccgcc aagcggaagt ttcagaaaag cggttatcga cattgcagca 1742341 gagaaacaga tgggaacagt catgtggaca gttgatacaa tcgattggca aaagccggct 1742401 ccgtctgtac ttcagacgag agtgttaagc aagatacata atggtgccat gattttaatg 1742461 catccgactg accctacggc ggaaagtctt gaagcgctga ttacacagat aaaagacaaa 1742521 ggatatgcgc ttggaacagt cactgaacta atggatgaaa caagactatt gaagtaacag 1742581 atgaaggcag cttgtctttg aataggagga acaaatttga ttaaacgata tacgtgtcaa 1742641 aatggtgtaa gaattgtgct ggaaaataac ccgacagtcc gttctgttgc gatcggcgta 1742701 tggatcggca caggttcgag acatgaaacg ccggagataa acggaatttc tcacttttta 1742761 gagcacatgt tctttaaagg gacgagcaca aaatctgcac gcgagatagc agaatctttt 1742821 gatcgtattg gcggccaggt caatgcgttt acttcaaagg aatatacctg ctactatgca 1742881 aaggtgcttg acgagcatgc gaattacgcg ctggacgtat tagcagatat gttctttcat 1742941 tcaacgtttg atgaaaacga gctgaaaaaa gagaaaaatg tagtatatga agaaattaaa 1743001 atgtatgaag atgcgccgga cgacattgta catgatttat tgagcaaagc cacttacggc 1743061 aatcattctt taggctaccc aattttagga acggaagaaa cgcttgcttc ctttaacggt 1743121 gactctctca gacaatacat gcatgattat tatacgccgg accgagtggt gatttcggta 1743181 gcgggcaata tatctgacag ttttatcaaa gatgtagaaa aatggttcgg gtcatacgag 1743241 gcgaaaggca aagcgacagg ccttgagaag cctgagttcc acacggaaaa actgacgaga 1743301 aaaaaagaaa cagagcaggc tcatttgtgc cttggattta aaggcttaga ggttggccat 1743361 gaacgtattt atgatttaat cgtcctcaac aatgtgctcg gaggcagcat gagcagccgg 1743421 ctgttccaag atgtgcgtga agataaagga cttgcttatt ctgtttacag ctatcacagc 1743481 tcatatgagg acagcggaat gctaacgatt tacggcggaa cgggtgcaaa tcagcttcag 1743541 cagctgtcgg aaacaattca agaaaccctg gccacattaa aacgtgacgg cattacctcg 1743601 aaagaactgg aaaacagcaa agagcaaatg aagggaagct taatgctgag cttagaaagc 1743661 acaaacagca aaatgagccg aaacggaaaa aatgaactgc tgctcggcaa acataaaaca 1743721 ttagatgaaa ttatcaatga attaaacgcc gtgaacttag agcgtgttaa tggccttgcc 1743781 agacaattgt ttaccgaaga ctatgcatta gcacttatca gcccttccgg caatatgccg 1743841 tcttaaaaag gaaagcctgc cccataatgg agcaggcatt ttttaatccc tttcatcata 1743901 catagtacaa gggggtgaca gacatgcggc tcagtgaatt atcgggaaag gaaattgtag 1743961 acatcaaaag agctgaacgg ctcggagtgc tcggccagac cgatttggaa atcaatgaac 1744021 aggatggaca gattacagca ctcctcattc ccacagttaa gtggtttggt ttgagaaagc 1744081 aaggtcatga cattcgtgtc ccatggcacc atattcaaaa gatcggttca gatatgatta 1744141 tattagatgt acctgaggaa atgcctcctc gacaagagta aatagcccaa ttgactgtga 1744201 agcgggctct aaagaaaaca tctgaaacat cggctgccgg agccgatgtt tttttatatg 1744261 gaaaaagcgc atcttttata ttcaccggta tttccttttg atcataagat gaaggggagc 1744321 ttaacaacta gagatccagt atatacaaag aaggtgaacg tttagaatgt taaccggatt 1744381 gaaaattgca gttatcggcg gtgacgcaag acagctcgaa attataagaa agctcactga 1744441 acagcaggct gacatctatc ttgtcggttt tgaccaattg gatcacggtt ttaccggggc 1744501 agtaaaatgc aatattgatg aaattccttt tcagcaaata gacagcatca ttcttccagt 1744561 atccgcgaca acaggagaag gtgtcgtatc gactgtattt tcgaatgaag aagttgtgtt 1744621 aaaacaggac catcttgaca gaacgcctgc acattgtgtc attttctcag gaatttctaa 1744681 cgcctattta gaaaacattg cagctcaggc aaaaagaaaa cttgttaagc tgtttgagcg 1744741 ggatgacatt gcgatataca actctattcc gacagtagaa ggaacgatca tgctggctat 1744801 tcagcacacg gattatacga tacacggatc acaggtggcc gttctcggtc tggggcgcac 1744861 cgggatgacg attgcccgta catttgccgc gctcggggcg aatgtaaaag tgggggcaag 1744921 aagttcagcg catctggcac gtatcactga aatggggctc gttccttttc ataccgatga 1744981 gctgaaagag catgtaaaag atatagatat ttgcattaat accataccga gtatgatttt 1745041 aaatcaaacg gtactttcta gcatgacacc aaaaacctta atattggatc tggcctcacg 1745101 tcccggggga acggatttta aatatgccga gaaacaaggg attaaagcac ttcttgctcc 1745161 cgggcttcca gggattgtcg ctcctaaaac agctgggcaa atccttgcaa acgtcttgag 1745221 caagcttttg gctgaaatac aagctgagga ggggaaataa ggatgtcgtc attaaaagga 1745281 aaaagaatcg ggtttgggct gaccgggtcg cattgcacat atgaagcggt tttcccgcaa 1745341 attgaggagt tggtcaacga aggagctgaa gtccgtccgg ttgtcacatt taatgtaaaa 1745401 tctacaaata cccgatttgg agagggcgca gaatgggtta aaaaaattga agacctgact 1745461 ggatatgagg ccattgattc gattgtaaag gcagaacctc ttgggccgaa gctgcccctt 1745521 gactgcatgg tcattgcgcc tttaacaggc aattcaatga gcaagctggc aaatgccatg 1745581 acggacagcc cggtgctgat ggcggcaaaa gcgacaatcc ggaacaatcg gcctgtcgtt 1745641 ctgggtatct cgacaaatga tgctcttggt ttaaacggaa caaatttaat gaggctcatg 1745701 tcaacaaaaa atatcttttt tattccattc gggcaagatg atccatttaa aaaaccgaat 1745761 tcaatggtag ccaaaatgga tctgcttccg caaacgattg aaaaggcact catgcaccag 1745821 cagcttcagc cgattctagt tgagaattat cagggaaatg actaaattta cagaaaatct 1745881 ttcccaaact aaaaaattcg gtcatcaccc gcatattcta tggtaaaata aaacgtaaaa 1745941 tcatagtcaa atcaattcaa tgaagctgat tggcggaagg agttttacag atgggaagag 1746001 gtttacacgt agctgttgtc ggagcgacag gggctgtggg acaacaaatg cttaaaacac 1746061 ttgaagacag aaactttgaa atggacacac ttacattgct atcttcaaaa cgctctgcgg 1746121 ggacaaaagt cacgtttaaa ggccaagagc tgactgttca ggaagcttct cctgagagct 1746181 ttgaaggggt aaatattgct ttgttcagcg ccggcggaag cgtatcacaa gcattggcac 1746241 cagaagctgt aaaacgcggc gctattgtta tagataatac gagtgcgttc cgcatggatg 1746301 aaaatacacc gcttgttgtg ccagaagtga atgaggcaga cttgcatgaa cacaacggca 1746361 ttattgccaa tccaaactgc tctacaatcc aaatggttgc ggcacttgaa ccgatccgca 1746421 aagcatatgg cttaaacaag gtcatcgtat caacttacca ggcagtatca ggagcgggta 1746481 atgaagctgt aaaagagctt tacagccaaa cacaggcgat tttaaataaa gaagaaatag 1746541 agcctgagat catgcctgta aaaggtgaca aaaaacacta tcaaatcgcc ttcaacgcga 1746601 ttccgcaaat cgataaattc caagataacg gctatacgtt tgaggaaatg aaaatgataa 1746661 atgaaacgaa aaaaatcatg cacatgcctg accttcaagt agcggctaca tgtgtgagac 1746721 tgccaatcca aactgggcac tcagagtccg tctacatcga aatagaccgt gatgacgcta 1746781 cagttgaaga tattaaaaat ctattgaaag aagctccggg cgtgacactt caggatgatc 1746841 caagccagca gctttatccg atgcctgctg atgctgtcgg caaaaacgat gtgtttgtag 1746901 gccgcatccg caaagacttg gacagagcaa acggttttca tttatgggtt gtttctgata 1746961 acctattaaa aggcgcggca tggaactctg ttcaaattgc agaaagcctg aaaaaactaa 1747021 acctcgtata aaagagagaa ttttctaaag acgaatagaa gagagtaagg cgctatcagc 1747081 ctgctctctt ctgttacgtc cgaataattt ggagtgaaaa cagtgaagat aattgttcaa 1747141 aagttcggcg gaacatcagt aaaagatgat aaaggccgca aactggcttt agggcatatt 1747201 aaagaagcaa tcagtgaagg atataaggtt gtcgttgtcg tttcagcgat gggccgaaaa 1747261 ggggacccgt atgcaacaga ttctttgctc gggctgcttt acggcgatca gtcagcgatt 1747321 tctcctaggg agcaggattt gcttttatct tgcggagaga ctatttcctc tgtcgtcttt 1747381 acaagcatgc tgcttgataa cggtgtgaaa gcagctgcgc tgacaggggc tcaggctggc 1747441 tttttaacga atgatcagca tactaatgcg aaaatcattg aaatgaaacc ggagcgttta 1747501 ttcagtgtgc tcgccaatca tgatgcggta gtcgtcgcag gcttccaggg cgcaactgaa 1747561 aagggtgata caacaacaat cggcagaggg ggcagcgata cgtctgcagc cgcactcgga 1747621 gcagctgttg atgcggaata catcgatatt ttcaccgatg tagaaggcgt gatgactgct 1747681 gacccaagag tggtagaaaa tgcaaaaccg cttcctgttg tgacgtatac ggaaatctgc 1747741 aacctggcgt atcagggggc caaggtcatt tctccgcgtg ctgtggaaat cgcaatgcag 1747801 gccaaggttc cgatccgcgt ccgttcgact tattcgaatg ataaaggcac attggtgaca 1747861 tcacatcact cttccaaggt cggcagtgat gtttttgaaa ggctgattac gggaatcgcc 1747921 catgtcaaag atgtcacgca gttcaaagtg cctgcgaaaa tcggccagta taacgttcag 1747981 actgaagtgt tcaaggctat ggcaaacgct ggaatcagtg tcgatttctt taacattaca 1748041 cctagtgaaa tcgtctatac ggtagccgga aataaaacag aaacagctca gcgtatttta 1748101 atggatatgg gctatgatcc aatggtgacg agaaactgcg cgaaggtatc ggcggtcggc 1748161 gcgggcatta tgggtgttcc cggtgttacg tccaaaattg tatcggctct ttcagaaaaa 1748221 gaaattccga tccttcagtc ggctgacagc catacgacga tatgggtgct cgtccatgaa 1748281 gcggatatgg ttcctgctgt aaacgctttg catgaagtgt ttgaactttc gaagtaaatg 1748341 tgattgaatc atgatgaggt gaataaaatg aatttcggaa atgtgtctac agcgatgatt 1748401 acaccctttg acaataaagg gaacgtagac tttcaaaaac tgtctacact gattgattac 1748461 ttgttgaaaa acggaacgga ttctttagta gtagcgggaa caactggaga atctccgacc 1748521 ctttcaactg aagaaaaaat tgcgcttttt gaatatacgg taaaagaagt aaacggacgg 1748581 gtgcccgtta tcgctggtac tgggagcaac aacacgaaag attccattaa gctgacaaaa 1748641 aaagctgagg aagcgggcgt ggacgctgtt atgcttgtta ccccgtatta caataaacct 1748701 tctcaagaag gaatgtacca gcattttaaa gcaattgcgg cagagacatc tcttccggtt 1748761 atgctctata atgttcctgg ccgtacggtt gcttctcttg ctcctgaaac gacgatccgt 1748821 ttggcggcag acattccgaa tgtggttgcg attaaagaag cgagcggaga cctcgaagcg 1748881 attacaaaaa ttattgctga aacacctgaa gacttctatg tctattcagg ggatgatgct 1748941 ctaacgcttc caattctttc agttggaggt agaggagttg tgtcagtggc gagccatatt 1749001 gcaggcactg atatgcagca aatgatcaaa aattatacga atgggcaaac agctaatgcg 1749061 gcactgattc atcagaaact gctgccgatt atgaaggaac tgtttaaagc gcctaatcct 1749121 gctccagtca aaacagcgct tcagctgaga ggtcttgatg tcggttctgt gcgtctgcct 1749181 ctagtcccat taactgagga tgaacgtctg agcttaagca gcacgatcag cgaactgtaa 1749241 gaaaatttca tacagtgaaa caaacgcggt cattctcaca ttcagctgag tttgaccgtt 1749301 tcttttacat attggttttc cctaaacctt ctgctttatc ttgttttcta aatttacttt 1749361 cagttataat aggaacaagt gatgatggac gggtatgaga ctaggaggat atagattttg 1749421 aaaaagaaaa atacagaaaa cgttagaatt atcgcccttg gcggtgtcgg agagattggg 1749481 aagaaccttt atgtcattga aattgactca gacatatttg tcgttgatgc cggccttatg 1749541 catccagaaa acgaaatgct cggtattgat gtagtgattc ctgacatatc atatttgatt 1749601 gaacgggctg accgcgtcaa ggcaatcttt ttaacgcacg ggcacgatga aaatatcggc 1749661 ggcgtttttt acttattaaa caagctgtcc gttccagtgt acggaacaaa actgacgctt 1749721 gcactgttaa gagagaaatt aaaacaatac ggacataacc gaaaaactga tttaagagaa 1749781 attcactcca aatctgtcat tacatttgaa tcaacaaagg tatcgttctt tagaacgatt 1749841 cacagcattc ctgattctgt aggtgtgagc tttaaaacat cacttggatc tattgtatgc 1749901 acgggagact tcaaatttga ccaaacacct gcacttaatc agacgtgcga cattggcgag 1749961 atcgccaaga tcggcaatag cggcgtgctc gctctgcttt ctgacagtgc aaatgcggaa 1750021 cggccgggtt acaccccttc ggaagcggct gtcagcggag aaatttcgga tgcgctgtat 1750081 aattcacaga accgggtgat tattgctgtt ttcgcatcca atattaaccg gattcagcaa 1750141 gtcattcatg cagcggctca aaatggcaga aagattgccg tagccggaaa aaatcttcaa 1750201 tctgtcctgc agctggcgag aaagttagga tatattgaag cagatgatga attgtttatt 1750261 tctgtacagg atgtcaaaaa atatccgaag cgcgaagtgg ccattattac agccggaagc 1750321 caaggtgaac cattagctgc tttgacaaga atggcaaaca aagctcacaa acagctgaac 1750381 attgaagaag gggatacggt ggtcattgcg tcaactccga ttcccgggca ggaactcatt 1750441 tactctaaaa cagtagatct tcttgcgaga gccggtgcac aagtcatctt tgcccaaaag 1750501 cgtgttcatg tatcaggcca cggctcacaa gaagagttaa agctgatgat caacctgctt 1750561 aaaccaaaat atttgattcc tgtaaacggc gaatacagaa tgcaaaaagc tcattcaaaa 1750621 atcgctgaag aaaccggcat gaagcgcagt gacatcttct taattgaaaa aggcgacgtc 1750681 gttgaattcc gcggccaaaa cgtaaaaatt ggggataaag ttccttacgg caatatttta 1750741 attgatggtt taggtgtcgg tgatatcggc aatatcgtat tgagagaccg ccgcttgctt 1750801 tcacaggacg gaattttaat cgttgtcatt acacttgata aacaaaagaa acatcttgta 1750861 tcaggaccag aaattatcac tcgcggcttt gtttatgtaa gagagtctga aggtcttatc 1750921 gtacaggcta ctgagcttgt acggtccatc gtgacagaag cgactgaaac atcaaatgtc 1750981 gaatggtcaa cgctgaagca ggcaatgcgg gatgctttga accaattcct ttatgaaaaa 1751041 acgaaacgta aaccgatgat catcccaatt attatggaag tataatgact gactaaagac 1751101 cggagctgct ccggtcttta ttttttgtcc ttcaagccgg gattgaatga agtatctttg 1751161 ttcataatac aaagagaaac tcggaaagga tgaaagcgag atggatcatc gtatggaaaa 1751221 cacagaagaa gagcgtcctg aaaaaaatga tgcgaaggac agcattatga ataaaataca 1751281 gcagcttggt gaaacgacgc ttccgcagct gccccaagat acaaatattc attgtctgac 1751341 cattatcgga caaattgaag gccatgttca gcttcctccg caaaacaaaa caacaaaata 1751401 tgaacatgtc atcccgcaga ttgtggcaat tgaacaaaat cccaaaattg aaggcttgct 1751461 gatcatatta aatactgtcg gaggagatgt tgaagctggt cttgccatag cggaaatgct 1751521 tgcatcttta tcgaaaccga ccgtttctat cgtgcttggc ggggggcatt caatcggcgt 1751581 tccgattgct gtatcctgtg attacagcta tatcgccgaa acagcaacga tgacgattca 1751641 tccagttagg ctcaccgggc tggtcatcgg ggtgccgcaa acgtttgaat acctggataa 1751701 gatgcaagaa agagttgtta aatttgtgac aagccattcc aatataaccg aagagaagtt 1751761 taaagagcta atgttttcaa aaggaaactt aacacgcgat atcggaacaa atgtagtcgg 1751821 taaggatgca gttaaatacg gattgatcga tcacgcaggc ggtgtcggac aggcaatcaa 1751881 taaactgaat gagctcatcg atgaagcaag gaaagaagaa ggacggatga ttcaatgatt 1751941 ctttataccg tgatgcctca ggaaattgtg tttgcagaac agaaccaaga gacaagcgca 1752001 catgagcaaa ttgaatataa aggtgtaccg cttctagtcg aaatgaaagg gaatgaagcg 1752061 gaagtcattc aaatcatgag caccaatcca atgcattttc tgcatccgga catttcaccg 1752121 ggacaaaagc tgaaattaaa cgtataagaa tccaaccctt ttttaagggc aaaatatgct 1752181 ataatagggg aatcctacag aaaaaacgca gcctgtaaac ggctgctttc ttcattatgt 1752241 atgaacttac attttttaac gcagtaaggt gatgagtgtg gcaaagaaaa aacgaaaatc 1752301 aagaaaaaaa caggcgaaac agctcaatat aaaatacgag ctcaacggat tgctgtgtat 1752361 agccatttca attatcgcaa tcttgcagct gggggtagtc gggcaaacgt ttatctattt 1752421 gttccgcttt tttgctggag agtggtttat tttatgcttg ttaggtttat tggtgttagg 1752481 agtctcactg ttttggaaga aaaaaacccc aagcctttta acgagacgaa aggccgggtt 1752541 gtactgtatt atcgcaagca tattgctgct ttctcacgtg cagctattta aaaatttgac 1752601 gcacaaaggg tctattgagt ctgcaagcgt ggtgcgcaat acgtgggaat tgtttttaat 1752661 ggacatgaat ggcagctctg cttcacctga tttaggcgga gggatgatcg gtgcgctgct 1752721 gtttgcggct tcacactttt tgtttgcgtc gactggttct cagatcatgg caattgtcat 1752781 gattttgatc ggaatgattt tagtaacagg acgctcgctg caagaaacgc taaaaaagtg 1752841 gatgagcccg attggacgtt ttataaaaga acaatggtta gcatttattg atgacatgaa 1752901 atccttcaaa tcaaatatgc agtcatcgaa aaaaacgaaa gcgccgagca aaaaacaaaa 1752961 accggcccgc aaaaaacagc aaatggaacc ggagcctcct gatgaagagg gggattatga 1753021 aacagtatcg cctcttattc attcagagcc gattatctca agcttttctg atcgtaatga 1753081 agaggaagag tctccagtta tagaaaagcg cgccgaacct gtgtcgaagc cgcttcagga 1753141 catccaaccg gagacaggtg atcaggaaac tgtttctgct cctcctatga cctttacaga 1753201 gctcgaaaat aaggattacg agatgccgtc actggatttg ctggcagatc cgaagcatac 1753261 cggccagcag gctgataaaa agaatattta tgaaaatgcg agaaagcttg aacgcacatt 1753321 ccaaagcttt ggcgtaaagg cgaaagtcac acaggttcat ctcggaccgg ccgtaacaaa 1753381 atatgaagta tatcctgatg tcggagtgaa ggttagcaaa attgtcaatt taagcgatga 1753441 tttagcgctt gcgcttgctg cgaaggatat caggatcgaa gcgcctatac caggcaaatc 1753501 agcaatcgga attgaagttc caaacgcaga agtggcaatg gtttcgctga aagaagtgct 1753561 ggagtctaaa ttgaatgaca gaccggatgc gaagctgtta attggactcg gccgcaatat 1753621 ttcaggtgaa gctgtattgg ctgagttaaa caagatgccc caccttttgg tcgcaggcgc 1753681 aaccggtagc gggaaaagtg tctgtgtcaa cggcattatt acaagtattt taatgcgggc 1753741 gaaaccgcat gaagtgaaaa tgatgatgat cgatcctaaa atggtagagc taaatgtcta 1753801 caacgggatt ccgcatttgc ttgctcctgt tgtaaccgat ccgaaaaaag cgtcgcaggc 1753861 tttgaaaaag gttgtcaatg aaatggagcg gcggtacgaa ttattttctc atacgggtac 1753921 aagaaatatt gaaggataca atgattatat aaaacgcgcc aacaatgaag aaggagcgaa 1753981 acagccagag ctgccttata ttgttgtcat tgtggacgag ctagccgatc tcatgatggt 1754041 cgcttcatct gatgtggaag attcgattac gagattgtcc caaatggcgc gggctgccgg 1754101 catccatctt attattgcga cacagcggcc atcggtggat gttatcacag gggtgatcaa 1754161 agcgaacatt ccgtcacgaa tcgcgttcag cgtatcttca cagacggatt caaggaccat 1754221 tcttgacatg ggtggcgctg agaagcttct tggccgcggc gatatgctgt ttttacctgt 1754281 aggggctaac aaacctgtcc gtgtgcaggg agcatttttg tcggatgacg aagtggagaa 1754341 ggtcgtcgac catgtgatta ctcagcagaa agcgcaatat caagaagaaa tgattcctga 1754401 ggagacgacg gaaactcatt ccgaggttac tgatgaactt tatgatgaag ctgttgaatt 1754461 aatcgtcggc atgcagacgg catctgtttc aatgctgcaa agaagattca gaattggcta 1754521 tacgagagcg gcgcgcctga ttgacgcaat ggaggaacgc ggtgttgtcg gaccgtatga 1754581 aggcagcaaa cctagggaag tattattatc aaaagagaaa tatgatgagc tctcttctta 1754641 atgaagggag ttccgctttc tatagttgtc aataatgata ttatgtaaac tgatcacctt 1754701 tctatttatt ttttcgacaa aacatgatat agttgtccca attgttcaat aatttttatc 1754761 gaaagtggtt tacggagggg aaacatgtct acaaaagctg ataatcggca cttgtatttg 1754821 aaagtaattg aacgaattaa agaggatata aaaaatggga tctacactga gaaggaaaag 1754881 ctgccttctg aatttgagct ttccaaaaag cttggtgtca gcagagcgac gctaagagaa 1754941 gccttgcgga tactggaaga agagcatgtg attatcagaa ggcatggtgt aggcactttt 1755001 gtccattcta agccgttatt tctttcgggt attgaacagc tgaacagtgt aaccaagatg 1755061 atagaacagg cgaatatgac ccctggcacg atttttctat catcacaagt gcttatgccg 1755121 tctgaagatg atacgaagag atttcacttg gcagaagggc aagaactttt ttaccttgaa 1755181 cgagtcagga cagctgacgg acagccgatt gtgtattgta tagacaaaat tccgatgaat 1755241 attttgccga attctttttc tcatcagcaa gaatctatgt ttgacctgct agagaaaaat 1755301 tcaggctccg taatcagcta tgcagtaact gatatagaac cgatcggcta tcacgatacc 1755361 atttctccag tgcttgaatg cgatccggaa acagctcttt tgctgttaaa acaaacccat 1755421 tacgatcagc acgataaacc ggtgctttat tctttaaatt attttagagc ggataaattc 1755481 agatttcatg ttttgcgtaa acgattctaa aaacggacgc ctgtatgtgt ctgttttttt 1755541 atttgcactg attcatgttt ctttgtacat actttcattc cggttaacgc aatatataag 1755601 ggatgacaag aaagtgaatg ggtgaaaatg ttgagagaga aaaatggaat gaaaaatatt 1755661 attgcattgt cttctgtccc gcttgtgatg acactcggga actccatgct gattcctgtt 1755721 cttccgatga tggagaaaaa gctgtctgtg acttcatttc aagtatcttt aatcattact 1755781 gtatattcag tagtagcaat tatttgcatt ccgattgccg gatatttgtc ggatcgtttc 1755841 gggagaaaaa aaatattgct tccatgcctc ctcattgcag gattgggggg agccgtagct 1755901 gcttttgcct cgacctatat gaaaaatcct tatgctatga tcttggcggg gcgggttctt 1755961 caaggcattg gttctgcagg tgccgctccg attgtcatgc cgtttatcgg cgacctgttt 1756021 aaaggagacg atgaaaaggt cagcgcgggt cttggcgata ttgaaaccgc caacacgtca 1756081 gggaaggtac tgagtcccat acttggagcc ttactggctt cttggtattg gtttgtaccg 1756141 ttttggttta ttccgttttt ctgtttgatc agctttttgc tcgtattgtt tttggtggcc 1756201 aagcctgaag aagatgaaga tgcgcctgct gtttctgagt ttattaagag tgtgaagaaa 1756261 atttttaaac aggatggtcg ctggctttat acggtcttca ttatcgggtg tgtcattatg 1756321 tttttgttat ttggcgtatt attttattta tcagatacgc tggagaacaa gtatgctatt 1756381 gacggagtag ctaaaggcgg attactggca atcccacttt tgtttttgtc aaccagttct 1756441 tttatagctg gcaaaaagat cggtaaagat aaaggccgaa tgaaattttg cgttgttaca 1756501 ggaatgattc tgttaaccct ttcgtttatt gccttgtggt ggaaccacag tttttatttt 1756561 ttatttgtct ttttaagctt tggcgggatt gggattggaa tggctcttcc tgctttagat 1756621 gcattgataa ccgaagggat tgaaagtgaa caatgcggaa ccatttcctc cttttacaat 1756681 agcatgcgct ttataggagt agctctcggt ccacctgttt ttgctgcatt aatgtctaat 1756741 gcaaactgga ttattttcat actctcggcg ttttgcagca tcgtttcttt atttttagtg 1756801 ctctttactg tagatgctaa aaaaagtgaa gaagaaaaaa acttagggac ggtctagcca 1756861 gccgtctttt tttgcgcttt cttgcacagt ttacaactgt acctatacag catgcggagg 1756921 ttattgtttc cttataaatc ctacagttgc tataattaca tgaaagagtg tttctgcgga 1756981 tgctgaaaat tggtcataat acatactaat taagaaatga acgaaggagg ttccatatgt 1757041 catatgttaa tgaactcaaa tcaaagcacg gcggtttaac cgcacacatt gtaaaaacag 1757101 aaaaattcaa aaccgtctcg cttattttta agatgcttgc gccgctgaca aaggatcaag 1757161 tcaccaaaag agcgcttctc ccgcatgtgc ttcttcgcgg aacgaaaagc catccgaaaa 1757221 ccgcaggatt gcgttcatac ttggatgagc tgtacggcac gtcagtatcg gctgatctta 1757281 cgaaaaaagg agagcggcat gtcattacgt tcaggcttga aatcccgaat gaaaaatatt 1757341 taaaagacca aacgccgctt ctcgagaaag ggctccagct tctcgcagaa ctcgtctttt 1757401 cacctgcttt ggagggagac gcttttcagt cacaatatgt ggctcaagaa aaacggacgc 1757461 ttaagcaaag aatccaagcc gtctatgatg ataaaatgcg ttattcgaat ttaaggctga 1757521 tacaggaaat gtgcaaaaat gatccttacg cgcttcatgt caatggtgaa atcgacgatg 1757581 tcgatgacat tacggcagag caattatacg aaacatacca aagcgctatc caaaaagacc 1757641 agcttgatct atatgttgtt ggcgacgtgg acagtaacca ggtacaatcg gcaattgata 1757701 agtatttcaa aacagaagag cgcactcttg gcatgattga aaacaatcac gctgatgaaa 1757761 aagttcagcc aaaagaagta attgatgaag aggatgtcaa gcaaggaaaa ctgaatatcg 1757821 gctaccgcac cagcatcact tatacagatc aggattatcc tgctttacaa gtgtttaacg 1757881 gattgttcgg cggattctct cattctaaac ttttcattaa tgttcgggaa aaagccagtc 1757941 ttgcttacta cgcggcttcg cgtatagaaa gttttaaagg cttgttaatg gtgatgtcag 1758001 gcattgaagt gaaaaatttt gaacaggcgg tttcgattat tgctgagcaa ttccaggcaa 1758061 tgaaaaatgg cgatttcagt gagcaggata tagcacagac aaaggccgtt attcgaaatc 1758121 aagtgctgga aacgattgat acagcatacg gtttatctga gtttttatat cagcaggccg 1758181 ctgctcaagt cgagattcct atcgaagact ttcttgccaa tattgagaat gtcacaaaag 1758241 aggatatcat taaagccggc gaaaagattc agcttgatac gacttatttc ttaaaaggga 1758301 cggagggtgc atcttgatca aaccaatcga atatgaacag cttcaggaga cgctgtatca 1758361 tgaaaaaatg tccaacggcc ttgatgttta cgttttgccg aaaaaaggct tcaacaagac 1758421 atatgcggtc tttacaacaa agtacggctc gatagataac cggtttgtcc ctttaggtaa 1758481 aaacgagatg gttcacgtgc cggacgggat tgctcacttt cttgagcaca agctgtttga 1758541 gaaagcggac ggagacgttt ttcaagattt cagcaaacag ggggcttctg ccaatgcgtt 1758601 tacgtcattt acaagaacgg cttacctttt ctcaagcaca tcaaatgttg aacgcaattt 1758661 agagacgctt atcgatttcg tacaggaccc atattttact gaaaaaacgg ttgaaaagga 1758721 aaaagggatt atcgggcagg agattaatat gtacgacgat aaccctgatt ggaggcttta 1758781 cttcggggtc attgaaaaca tgtacaaaga gcatcctgtc agaattgaca tagcgggaac 1758841 agtggaaagc atttcacata ttacaaaaga ccttctttat gaatgctatg aaacgtttta 1758901 tcacccgagt aacatgctcc ttttcattgt cggccctgta gatcctgaag cgattatttc 1758961 tcaggtaaga gaaaaccagg ggaaaaagcc gtatactgat cagccggaga tcaaacgaga 1759021 agaagtgaaa gagcaagaag cggttttccg aaaagaaaaa gagatcaaaa tgaacgtgca 1759081 gggaccgaaa tgccttgttg ggctgaaatc caaaaatccg tttaaattag gcaaagagct 1759141 cttaaagcat gaactttcaa tgaacttatt gcttgaagct ctttttggca aaagctctgc 1759201 ccagtatgaa tcactttatg aaaaaggata tattgacgaa acgttcagct ttgattttac 1759261 tgctgaatat gggttcggtt ttgcggcgat cggcggagat acgcctgagc ctgatcaatt 1759321 ggctgaagac atttcaagca tgcttttgcg cgccggtgaa ctgattactg ctgaaaagat 1759381 tgaacttgcc agaaagaaaa agatcggcac attcttaaaa gcgctgaatt cccctgaata 1759441 catcgccaat caatttaccc gttatgcgtt cttggatatg agcctgtttg atgttgtaac 1759501 ggtactcgag cagattaccc tcgaggatgt ccagaacgta atacaagagg aaatcgctgc 1759561 agacagactg actgtctgca aggttgttcc taaatcataa acaaaacatc cctccagtgt 1759621 gaggggtgtt tttctgcgga aagaaggaaa gaggatgaac aaaacagcac taatcaccgg 1759681 agcaagcggc ggcattggca aaagcatcag cgaaaccctt gcagctagag gatacaatct 1759741 gctgctgcat tacaatacaa atcaaaacgc ggcagcggag cttgctgaaa aactaagtca 1759801 gatgtttggc gtaaatgcgg agatattaca agctgacctg tccgcgcaag atggagcaga 1759861 taagctgaca agttcaattg ttcagccgat tgatgcgatt gttttaaaca gcggacgaag 1759921 ccattttggg ctgattacgg atgtagataa cgcaacggtc caggaaatgg ttcagcttca 1759981 tgtggcgagt ccgtatatgc tgacgagaaa ccttctgcca ggcatgattc ggaataaatc 1760041 gggagcgatt gtggctgtca gctcgatttg gggagagact ggagcatcct gtgaagtgtt 1760101 gtacagcatg gcaaaaggag ctcagcattc atttgtaaaa ggattggcta aggagctggc 1760161 gccaagcgga atcagagtaa acgccgtagc gccgggtgca gttgatacaa atatgatgaa 1760221 tcaatttacc ccggctgaaa aagaagagat cgctgatgag attccgatcg gccggctggc 1760281 ccggccgcaa gaaattgcgg atgcaacagc ttttctcctg tctgaaaaag cgtcatatat 1760341 caccggccaa attctgtcgg tgaatggcgg ctggcactgc tgatccgaaa atattcggtg 1760401 tatagtttct tttgcgaagg acacaataat cttgtaactt cacatgaaat ggaggaaaca 1760461 agcatgtcag tattagaaaa ctgggatagc tggaaaaact tccttggcga ccgtctgaac 1760521 tatgcgcaag ataaaggtat gagccaggat acgattacag atcttgcgac agaaatcggc 1760581 agctacttgg ctaatgaagt ggaatctaag aacgagcagg aaaaagtgct ggcagatctt 1760641 tggagtgtag catcaaaaga tgaacagcac gccattgcca atatgatggt taagcttgtt 1760701 gaaaataaca gcactcacta ggaagagagg ggatttttcc tctctttttt atgttttcct 1760761 catcacagca acattcttct ttctaattag agaaaaatgc tttatgataa aggaaggtaa 1760821 aattttgcca caatgaaggg ggtatatcat ttggcaaagc tcgaatggta ttttgaatat 1760881 gaaattcaag tgaaccgccc cggactgctc ggggatattt catctcttct tgggatgctt 1760941 tctatcaaca tcgtaacgat aaacggcgtc gatctttcca gaaggggaat gctcctcagg 1761001 tgccgccata tagatcaaat taaacgatta gaatcaatct taaaaacgat ggaaacaatt 1761061 aaagtaacga agcttagaga accgaggctt cgcgaccgtc ttgccgtacg ccacggccgt 1761121 tatattcaac gggatgccga tgacaagaaa acgttccgct ttgaacggga cgagcttggc 1761181 ttattagtcg attttatggc cgaattgttc aaaaaagaag gccataaatt aatcggaatc 1761241 agaggtatgc cgcgtgtcgg gaaaacggaa tcgattgtag cctctagtgt gtgcgagcaa 1761301 aaggtggctg tttgtgtcat caaccttgct gaagcagacg ataagaagcc agctgattgc 1761361 cgatgaatac agcactgaaa atgtctttat cgttgacgga attgtgtcaa cacgaagagg 1761421 gtcagaacgc catctccagc tggtccgaga aatcatgcgg ctgcctgcaa caaaagtggt 1761481 ggagcatccg gacatattcg ttcaaaatac agagtataca ctagatgact ttgattatat 1761541 tattgaactg agaaatgacc ctgatgaggt tattacatat gaacatgccg aggaacccca 1761601 aatgtttgat caatccgggt tttcaagctt tgatttttaa aattggaagg tgtttgttgt 1761661 gactgaacta ggaatccggc tcaaagaagc cagagaggaa aaagcaatgt cattggatga 1761721 tctccaagcg gcaacaaaga ttcaaaaaag gtatttaacc gccttggagg aaggaaacta 1761781 tgacattatt ccggggaagt tttatgttcg ggcattcatc aagcaatatg cagaagccgt 1761841 tgggcttgat gcggatcagc tgtttgagga gcataaaaaa gatatcccta atacgtatca 1761901 tgatgatgtg tctgaaaaga tctccggcat gaatcttcaa aaggaaatgc caaagccagc 1761961 atctaaggcg ctggagctgc tgccaacaat acttgttatt ctcggcgtga ttgtcgtgat 1762021 tgccattgtg tacgcgatca ttcaatttgc caatcacaaa aacagtgatg atcacaatgc 1762081 ggcatcagaa aaagcaatta cgcaaagtga gagcaagtac gaaatcccta aagattcaac 1762141 gctgaaagag aatcaaaata acagctctga aaaagagaca gacactaaaa aagaaacgaa 1762201 agaaaacgaa gataagaaaa aagaaaatga cagtgagaag ctggagatta aagctgctgg 1762261 cactgaagga tcgttaacga cttatgaagt gtccggcgct gataaaatcg agctggaact 1762321 gaaggcatca gacagctcct ggattagagt gcgcgatgaa aacagcagct ctttaaaaga 1762381 aggaacgctg aaaaaagacg aaacctataa aaaagacata actgatcaga aacaagttga 1762441 tatccgcacc ggatatgcac ctaatctgaa aataaaaatc aacggtaagg ttctttcata 1762501 tgaacttgat ccgaaaaaag tgatggcaca aaccataaag attgtaaata aaaaggaaga 1762561 aaagtcatct taattaccag atgacttttc ttcacgtccg agtatgaaat tggaggggct 1762621 ttatgtttaa cttaccaaat aaaatcacac tagctagaat cgcattaatc ccaatcttca 1762681 tgattatcat gctggcgccg tttgactggg gcaggctcga agttggagac gaatccatcc 1762741 cggtcgcaca tttggcgggg gccattctat ttattattgc atctacaaca gactgggtgg 1762801 acgggtatta tgcccgaaaa ttaaatctcg taacaaactt cgggaaattt cttgatccgc 1762861 ttgcggacaa actgctcgta tccgcagcgt taattatcct tgttcaattt gatctcgctc 1762921 cagcttggat ggtcattgtg attatcagca gggagtttgc cgtgacaggt ttaaggcttg 1762981 tcttagccgg aacaggagaa gtcgtagctg ctaacatgct tggtaaaatc aaaacctggg 1763041 cacagattat tgcggtatct gcattgcttc ttcataatct tccatttgaa cttgtgtcat 1763101 tcccgtttgc agacttggcg ctgtgggtag ccgtcttctt tactgtcgtc tcaggctggg 1763161 aatatttctc taaaaattgg gaagcgttaa aaacatctaa ctaagaaaga aggacttcgt 1763221 catggaattt ccaaaaaaag cagaaataat tgcagtcggt tcagagttgc tgcttggtca 1763281 aatcgccaat acaaatgctc aatttatcag caaacagctc gctgaaatcg gggtcaacgt 1763341 attttatcat acagcggtcg gagataaccc ggagcggctg aagcaggtca tccgcattgc 1763401 tgaagaacgc tctgacttca ttattttttc aggagggctt ggacccacaa aagatgatct 1763461 gacgaaagaa acgattgcaa atacgctggg acgtccgctt gtgttaaatg atgaggcatt 1763521 ccaatccatt gaggactatt tcaaacgaac aaaacgcacg atgtcaccta ataaccgaaa 1763581 acaggcgctt gtgatcgaag gctctgacgt gctggcgaat cactttggaa tggccccggg 1763641 aatgctcaca gagcatgaat cgcgctatta tatgcttctt cctggaccgc cgagcgaatt 1763701 gcgtccaatg tttgaaaacg aggcaaagcc tcttctgctg aaaaagatgg gttcaaatga 1763761 aaaaattgtg tcaactgttc ttcgcttttt cggtatcggt gaatctcagc ttgaagccga 1763821 tttggaagat attattgatg cacaaaccaa tccgacaatt gcgcctttgg cggctgatgg 1763881 agaggtgacg ctgcgtctga cagccaaaca cgccgatgaa aaggaaacag agcgtctgtt 1763941 aaaagaaaca gaggccgtta tcttagagcg tgtcggtgaa tttttctatg gttacgatga 1764001 tacttctctt gtaaaagagc tatctatagc atgtaaggaa aaaggcataa caatttctgc 1764061 ggcagaaagc tttaccggag ggctgttttc tgaatggctg acggatcata gcggtgcctc 1764121 aaaattattt gccgggggcg ttgtttgcta tacaaacgac gtgaagcaga atgtgcttgg 1764181 tgtcaagaag gaaacattag atcgttttgg ggcggtcagc aaggagtgcg catccgaact 1764241 ggctaagggt gttcaaaaac tcactggcag cgatatcggc attagcttta ctggtgtagc 1764301 aggacctgat gctcaagaag ggcatgagcc tgggcatgtg tttatcggca tttccgcaaa 1764361 tggtaaagaa gaggttcacg agtttcactt tgcgggctcc agaacgggga tcagaaaacg 1764421 cggcgctaaa tacggctgcc atttaatctt aaagctttta gagcaaaaat aatattttca 1764481 gcacattatc ctcctaagaa aacatgattt ctctgataca ttatgatatt ttgataggaa 1764541 tcacgccaag aaaaaatccg aatatgcgtt cgcttttttc ttggcaaatc ccttcaaaca 1764601 gggtatagta tatgtagtgg taacataaag gaggaaaaaa tagaatgagt gatcgtcagg 1764661 cagccttaga tatggctctt aaacaaatag aaaaacagtt cggcaaaggt tccattatga 1764721 aactgggaga aaagacagat acaagaattt ctactgtacc aagcggctcc ctcgctcttg 1764781 atacagcact gggaattggc ggatatcctc gcggacggat tattgaagta tacggtcctg 1764841 aaagctcagg taaaacaact gtggcgcttc atgcgattgc tgaagttcag cagcagggcg 1764901 gacaagccgc gtttatcgat gcggagcatg cgttagatcc ggtatacgcg caaaagctcg 1764961 gtgttaacat cgaagagctt ttactgtctc agcctgacac aggcgagcag gcgcttgaaa 1765021 ttgcggaagc attggttcga agcggggcag ttgacattgt cgttgtcgac tctgtagccg 1765081 ctctcgttcc gaaagcggaa attgaaggcg acatgggaga ttcgcatgtc ggtttacaag 1765141 cacgcttaat gtctcaagcg cttcgtaagc tttcaggggc cattaacaaa tcgaagacaa 1765201 tcgcgatttt cattaaccaa attcgtgaaa aagtcggtgt tatgttcggg aacccggaaa 1765261 caacacctgg cggccgtgcg ttgaaattct attcttccgt gcgtcttgaa gtgcgccgtg 1765321 ctgaacagct gaaacaaggc aacgacgtaa tggggaacaa aacgaaaatc aaagtcgtga 1765381 aaaacaaggt ggctccgccg ttccgtacag ccgaggttga cattatgtac ggagaaggca 1765441 tttcaaaaga aggcgaaatc attgatctag gaactgaact tgatatcgtg caaaaaagcg 1765501 gttcatggta ctcttatgaa gaagagcgtc ttggccaagg ccgtgaaaat gcaaaacaat 1765561 tcctgaaaga aaataaagat atcatgctga tgatccagga gcaaattcgc gaacattacg 1765621 gcttggataa taacggagta gtgcagcagc aagctgaaga gacacaagaa gaactcgaat 1765681 ttgaagaata aaaataaaat aagtttcaaa tgatacaaaa ggctgagtga aaaactcagc 1765741 ttttttgtat tttgcaaaaa aatgataaaa atattgcttt ttttgacaac ttttttaggg 1765801 ctttattcgt ctaacaaaac gtgtgcaaaa tggaatttat tttgggagga aaaaatgaat 1765861 gacaagccca acccgcagaa gaactgcgaa acgcagacgg agaaaactaa ataaaagagg 1765921 aaaactgttg tttggtcttt tagcagtgat ggtttgcatt acgatttgga atgctcttca 1765981 tcgaaatagt gaagaaaacg aaccatctca agaaactgca gcggtttcaa ataccgatca 1766041 gaaaaaagag gtcaaaaaga aaactgccaa aaaatcagag gaacaaatca aaacagtgga 1766101 tcgaaaccaa aaaatcagca attatttaaa agagatcggt ttcagcggaa cagccatgat 1766161 tgtcagaaat ggagaaatcg taacaaataa aggttttggc tatgctgacc gtaaacacta 1766221 cattcaaaat aatccattga catcttttta tgtcggttca tcacaaaaag cgctgattgc 1766281 aactgctatt ttgcagcttg aggaaaaggg gaaacttcag acaagtgatc cggtaagcac 1766341 gtatttacct cattttccca acggacaaac gattactttg aagaatctgc ttacacatac 1766401 atcggggata aacggacata ttgaaggaaa cggcgccatt actccggacg atttaataaa 1766461 agatatagaa cttcagggaa tcaaacgtca gccgggcgta tgggactaca aggattccaa 1766521 ctattctgtt cttgcttata ttattgctga agtaagcggt gagccctatg aacagtacat 1766581 aaagaatcat atttttaaac ctgcgggaat gacgcatgca ggcttttaca aaacatatga 1766641 aaaagaacct tatcctgccg tcgggtataa gatggagggc agcaaaacag ttacaccgta 1766701 tatacctgat ttatcccagc tgtatggagc gggtgatatt tatatgagcg ctatagatat 1766761 gtacaaattt gaccaagcgc tgatagacgg aaaactgtat tcgcaaaaaa gctatgaaaa 1766821 gatgtttacg ccagggagca gctccacata cggcatggga ttttatgttg ctcccggaag 1766881 ctattcaaac catggtgtta tgccgggctt caatatcttg aacagcttta gcaaatctgg 1766941 gcaaaccatt gttattttgt tctcaaacat tcaaaataat gctaaattgg gccaagtgaa 1767001 caataaaata taccagcttc taaatcaaga atgattggcg atcttctttt ggatgaattg 1767061 cattcggcac gtgaaaagaa gactggcctg caaacgttaa gatggcaagc ttgacaagta 1767121 tttccgacac atttacaatg aagttgtaac atttgttttt ttaacatgat tgttaaacca 1767181 tttaaacttg acaagggcga tgaacacact cattccctgt gaaggttctg tatgttgaga 1767241 aaactagaca atgtacatgc cgacactttt taagcaacaa ccaagttcat agcaagagga 1767301 ggtgaaagta tgaccccaat tatgatggtt ctcatctcca ttttgctgat tctactcggt 1767361 ttagttgttg gctactttgt tcgtaaaacc attgccgaag cgaaaattgc gggcgcacgc 1767421 ggtgcagccg agcaaattct tgaagatgcg aagcgtgatg ctgaagcact gaaaaaagaa 1767481 gctctgcttg aagcaaagga tgaaatccac aaacttcgaa tagatgctga acaggaagtt 1767541 cgtgaaagac gaaatgagct tcaaaaacaa gaaaaccgtt tactccaaaa ggaggaaaac 1767601 cttgatcgca aacatgaggg aattgataaa cgggaagcga tgttggagaa gaaagatcat 1767661 tctctgaatg aacgacaaca acatattgaa gagatggaaa gcaaagtgga tgagatgatt 1767721 cgtatgcagc agtctgagtt ggaacgaatt tcgagtctga ctcgtgacga agcgaaacaa 1767781 atcattcttg agcgggttga aaacgagctt tcacatgaca tcgccatcat gacaaaagaa 1767841 actgaaaacc gtgcgaaaga agaggcggat aagaaagcga aaaacattct ttcactcgcc 1767901 ttacagcgct gcgcagcgga ccacgttgcc gaaacaacgg tatcagttgt caatcttcca 1767961 aatgatgaga tgaaaggacg tatcatcgga cgggaagggc gtaacattcg tacgcttgaa 1768021 acgctgacag gaattgacct gattattgat gatacgcctg aagctgtcat tctttccgga 1768081 tttgatccga tcagacgtga gacagccaga attgctcttg ataaactcgt tcaggatggc 1768141 cgtattcatc cggcacggat tgaagaaatg gttgaaaaat ctcgccgcga ggtcgatgac 1768201 tatattcgtg agatgggtga gcaaacgaca tttgaggttg gcgttcatgg cctccaccca 1768261 gatctcatca agatcctcgg ccgcttaaag ttccgtacaa gctacggtca aaatgtgctt 1768321 aagcattcca tggaagtcgc attcttggcc ggtctaatgg catcggagct tggtgaagac 1768381 gcaaagcttg ctaaacgtgc gggtcttctt cacgacatcg ggaaagcaat tgaccatgaa 1768441 gtagaaggaa gccacgttga gatcggggta gagcttgcga ccaaatataa agagcaccca 1768501 gtcgtgatta acagtattgc atcacaccac ggggacgagg agccgacttc cattattgct 1768561 gtactggtag ctgcagcaga tgcgctttcc gctgcaagac ctggcgcaag aagtgagacg 1768621 ctcgagaatt atattcgaag acttgaaaaa cttgaagaaa tttctgagtc ctacgaaggt 1768681 gttgaaaaat catttgccat tcaggctgga cgcgaagtgc gaattatggt gaagccggat 1768741 tcaattaatg atcttgaggc tcatcgactg gcgcgagata tccgcaagcg aattgaggac 1768801 gagctcgatt atccaggtca tattaaggtg acagtaatca gagagactcg agccgtagag 1768861 tatgcaaaat aaagtgatgc gctaagcatc actttatttt tttgacggca aggaattttc 1768921 aagaagaaag gatttacaaa atgagaattt tatttatcgg agatgttgtc ggttcaccgg 1768981 gccgtgacat ggtcaaagaa tatgtaccaa agctaaaaac aaaatataag cctcacttta 1769041 ccattattaa tggtgaaaac gccgcacatg gaaaaggcct gacggaaaaa atttatcaca 1769101 gcttaatcca gtccggcgca gatgcaatca caatggggaa ccacacatgg gacaaaaaag 1769161 aaatatttga ttttatagat gacgttccga acttggttcg cccggcaaac tttcctgaag 1769221 gaacaccggg gaaagggatc acatatgtga aagcaaacgg caaagaacta gcagtcatta 1769281 atttgcaggg acgtacgttt ttgccgccgc ttgatgaccc gtttttaaaa gcggatgaat 1769341 tgatcgcaga agctgcgaaa agaacaccgt acatttttat tgactttcat gccgaagcga 1769401 caagtgaaaa gctcgcactt ggctggtaca cggatggacg ggcatcggct gtagtaggaa 1769461 ctcatacaca cgtgcaaaca gcggataacc gcattttgcc gaagggaacg gcatatatta 1769521 ctgatgtggg aatgactggc ccgtatgacg gtatactggg gatggacaga gagacgatta 1769581 ttaagcgatt caaaacgaac cttccagtcc ggtttactgt cgctgaagga aaaacaacgc 1769641 tcagcggagt tgtcattgac attgacgatc aaacgaaaaa agccgtgaaa attgagcgta 1769701 ttttaatcaa cgatgatcac atgttctttg aatagttgaa catatggtta ttttataaaa 1769761 atattaaaaa gaaaagcagg aatatagcaa ctccttagtg aatatagtaa aaatggaagg 1769821 tagcccgcta tttttgaaaa gcattgtggg gatggctttt tggatagcaa catctaataa 1769881 tgattgttct aatgaacact cacttatcca ttgtaaaact aagggggagc agaaatggaa 1769941 atcttaaaag tttcagcaaa atcgagtcca aattcagtgg caggtgcgct tgcaggcgtg 1770001 ttgagagagc gaggagccgc cgagattcaa gcgatcggag cgggtgcatt aaaccaggct 1770061 gtaaaagctg tggcgattgc caggggattt gtggcgccaa gcggcgttga tttgatttgt 1770121 attccggctt ttacagatat tcaaatcgat ggggaagaaa gaacagcgat taaattaatc 1770181 gtggagcctc gctaaaaaca aataaagcat tctcaacctg tttgcgtaat gcaaacaggt 1770241 tgtttttcat ttattgtgat attttctccc gatagtattt ttagcacata aatgagcgaa 1770301 tatacaaaat cagaaatgag ctaaaacgtt tcaaaaaaaa tttccgccca tttttcaaga 1770361 cagatacttt tgtccttctg gaaaagacag ttctgtttac gcttattcca tatcatggta 1770421 caatccgaat ataacaagaa tttttcaagg aggattgtac atgcagagtg gaaagatgaa 1770481 agctctaatg aaaaaggacg gggcgttcgg tgctgtgctg actgaagttc ccattcctga 1770541 gattgataaa catgaagtcc tcataaaagt gaaagccgct tccatatgcg gcacggatgt 1770601 ccacatttat aattgggatc aatgggcacg tcagagaatc aaaacaccct atgttttcgg 1770661 ccatgagttc agcggcatcg tagagggcgt gggagagaat gtcagcagtg taaaagtggg 1770721 agagtatgtg tctgcggaaa cacacattgt ctgtggtgaa tgtgtccctt gcctaacagg 1770781 aaaatctcat gtgtgtacca atactgctat aatcggagtg gacacggcag gctgttttgc 1770841 ggagtatgta aaagttccag ctgataacat ttggagaaat cccgctgata tggacccgtc 1770901 gattgcttcc attcaagagc ctttaggaaa tgcagttcat accgtactcg agagccagcc 1770961 tgcaggagga acgactgcag tcattggatg cggaccgatt ggtcttatgg ctgttgcggt 1771021 tgcaaaagca gcaggagctt ctcaggtgat agcgattgat aagaatgaat acaggctgag 1771081 gcttgcaaaa caaatgggag cgacttgtac tgtttctatt gaaaaagaag acccgctcaa 1771141 aattgtaagc gctttaacga gtggagaagg agcagatctt gtttgtgaga tgtcgggcca 1771201 tccctcagcg attgcccaag gtcttgcgat ggctgcgaat ggcggaagat ttcatattct 1771261 cagcttgccg gaacatccgg tgacaattga tttgacgaat aaagtggtat ttaaagggct 1771321 taccatccaa ggaatcacag gaagaaaaat gttttcaaca tggcgccagg tgtctcagtt 1771381 gatcagttca aacatgatcg atcttgcacc tgttattacc catcagtttc cattagagga 1771441 gtttgaaaaa ggtttcgaac tgatgagaag cgggcagtgc ggaaaagtaa ttttaattcc 1771501 ataaaggggg ataaacatga cgaaggaatt tgagttttta aaagcagagc ttaatagtat 1771561 gaaagaaaac catacatggc aagacataaa acagcttgaa tctatgcagg gcccatctgt 1771621 cacagtgaat caccaaaaag tcattcagct atcttctaat aattacctcg gattcacttc 1771681 acatcctaga ctcatcaacg ccgcacagga ggccgttcag cagtatggag ccggcaccgg 1771741 atcagtgaga acgattgcgg gtacatttac aatgcatcaa gagcttgaga aaaagctggc 1771801 agcctttaaa aaaacggagg cggcacttgt attccaatca ggcttcacaa caaaccaagg 1771861 cgtactttca agtattctat caaaagagga cattgtcatc tcagatgaat tgaaccatgc 1771921 ctctattatt gacggaattc gactgacaaa ggcggataaa aaggtgtatc agcacgtcaa 1771981 tatgagtgat ttagagcggg tgctgagaaa gtcaatgaat tatcggatgc gtctgattgt 1772041 gacagacggc gtattttcca tggatggcaa catagctcct ctgcctgata ttgtagagct 1772101 cgctgagaaa tatgacgcat ttgtgatggt ggatgacgcc catgcatccg gagtacttgg 1772161 cgaaaacggc aggggaacgg tgaatcactt cggtcttgac ggcagagtgc atattcaggt 1772221 cggaacatta agcaaggcaa tcggagtgct cggcggctac gctgcaggtt caaaggtgct 1772281 gatcgattat ttgcgccata aaggccgtcc atttttattc agcacatctc atccgccggc 1772341 agtcactgca gcttgtatgg aagcgattga tgtcttgctt gaagagccgg agcatatgga 1772401 gcgcttgtgg gagaatactg cctattttaa agcaatgctt gtgaaaatgg gtctgactct 1772461 cacgaagagt gaaacgccga ttcttcctat tttaataggt gatgaaggtg tggcaaagca 1772521 attttcagat cagctccttt ctcgcggtgt ttttgcccaa agtatcgttt tcccgactgt 1772581 agcaaaggga aaagccagaa ttcgcacgat tataacagca gagcacacca aagatgaact 1772641 ggatcaggcg cttgatgtca tcgaaaagac ggcaaaggag ctccagctat tgtaacaaga 1772701 ggaagagttt actcttcctc ttttgattcc ttattgatta ttattctcaa tgagtgtaca 1772761 atgataggtt gccagttgtg cagagcttca ataaccttta tactgaaggg tggaagtttg 1772821 gtttgaaagg agaaaatatg acatgaatga aaaacaaaaa ttagagagcg gacaagttca 1772881 tccatcggac aaaaaatccg agaaggatta cagcaagtac tttgaagctg tttacattcc 1772941 gccttcttta aaagacgcga aaaaacgagg caaggaagcc gttacttatc ataatgactt 1773001 taaaatttct gaacaattta aaggattggg agacggaaga aagttctata tccgtacgta 1773061 cggctgccaa atgaatgaac acgatacaga ggttatggca gggatcttta tggcgctcgg 1773121 ttacgaagcg acaaactctg ttgacgatgc caatgtcatt ttgttaaata catgtgcaat 1773181 ccgtgaaaat gctgaaaaca aggtgtttgg tgagctcggg cacttaaaag cactgaaaaa 1773241 aaacaatccc gatctgattt taggcgtgtg cggctgtatg tcccaagagg aatcagtcgt 1773301 gaaccgtatt ttgaaaaaac atccgtttgt cgatatgatt ttcggaacgc ataacattca 1773361 tcgcctgccg gagcttttgt cagaagcata cctttcaaaa gaaatggttg tagaagtttg 1773421 gtctaaggaa ggggacgtta ttgaaaacct tccaaaagtc cgaaatggaa aaattaaggg 1773481 ctgggtcaat atcatgtacg gctgtgacaa attctgtacg tattgcattg tgccttacac 1773541 acgcggaaaa gaaagaagcc gccgccctga ggatatcatt caggaagtga gaaggctcgc 1773601 aagtgaaggc tataaggaaa ttactctgtt aggccaaaac gtaaacgcgt atggaaaaga 1773661 ctttgaagat atgacgtacg gacttggtga tttgatggat gaactgagaa aaatcgatat 1773721 cccgagaatc cgttttacaa cgagtcatcc gcgcgacttt gacgaccgcc tcattgaagt 1773781 gctggcaaaa ggcggaaatc tgcttgatca cattcatctt ccggttcaat caggaagctc 1773841 agaagttctc aagctgatgg cccgcaaata tgacagagag cgttacatgg agctggtgcg 1773901 aaaaattaaa gaagcaatgc caaacgcttc tttgacaacg gacattatcg tcggatttcc 1773961 aaatgaaacg gacgaacagt ttgaagaaac gctttctcta taccgtgaag tggagtttga 1774021 cagcgcctat acgttcattt actctccgcg tgaaggcact ccggctgcta agatgaaaga 1774081 taatgtaccg atgcgtgtga aaaaagaacg cctgcagcgt ctaaacgcac tggtgaatga 1774141 aatttctgct aaaaaaatga aggaatacga aggcaaggtt gtcgaagtat tagttgaggg 1774201 tgaaagcaaa aataaccctg atattcttgc tggctatact gaaaaaagca agcttgtcaa 1774261 tttcaaaggg ccgaaggaag ccatcggcaa aatcgtccgc gtgaaaatcc agcaagcgaa 1774321 aacatggtcg cttgacggag aaatggtagg agaagcaatc gaggtgaaat gagatgacgc 1774381 tctactcaaa aaaagacatt gtgcagcagg ctcgaaacct tgcaaaaatg atttctgaaa 1774441 cagaagaggt tgattttttc aaacgggctg aagcgcaaat caatgagaat gacaaagtgt 1774501 ccacaatcgt taatcagatt aaagccctgc aaaagcaggc tgtcaatctg aagcattatg 1774561 aaaagcatga agcgctcaaa caagtagaag caaaaattga cgcgctgcaa gaagagcttg 1774621 aagagattcc tgttatccag gaattcagag actcgcaaat ggaagtaaat gacctactgc 1774681 agctcgttgc acacaccatt tccaaccaag tcacaaatga aatcatcaca tcaaccggag 1774741 gcgacctgct gaaaggggaa accggttcaa aggtgaagca ttcaaataac agctgttctc 1774801 tctaaacacg gtgcctttac aggcccgtgt ttttttatca tttgtgcggt taaaaatgaa 1774861 ctaaataatc tatgtaccaa atgttcaatt ggtttttctg tgctcagccg cgtataaact 1774921 ttatcgcact tataagtaaa gtttctaggc acccctgcat acaatggaac agaaactttg 1774981 tatttttata ttttatttat aaaaatgcac actagacaaa tgcccagcat aagataacac 1775041 gaagaagaac aaggaggcat gccggaatgt ctgaatacag ggaaattatt acgaaggcag 1775101 tagtagcgaa aggccgaaaa ttcacccaat gcaccaacac catctcgcct gagaaaaaac 1775161 cgagcagcat tttgggtggt tggattatta accacaagta tgacgctgaa aaaattggaa 1775221 aaacggtaga aattgaaggg tattatgata taaacgtatg gtactcttac gcggacaaca 1775281 caaagacaga ggttgtcaca gaacgggtaa aatatgtaga tgtcattaaa ctcagataca 1775341 gagacaataa ttacttagat gatgagcatg aagtgattgc caaagtgctt cagcagccaa 1775401 actgccttga agtgaccatt tcgccgaatg gaaataaaat cgttgtgcag gcagaaagag 1775461 aatttttggc ggaagtggta ggggaaacaa aggtagttgt tgaggtcaat cctgactggg 1775521 aagaggatga cgaggaagat tgggaagatg agcttgatga agagcttgaa gacatcaacc 1775581 cggagttttt agtgggagat cctgaagaat aaaaaaggga ctaggggaga cagtaccccc 1775641 aagtctcttt tttatattga tatatcattc ttttatcact ttttgtttat gttataatga 1775701 aggttggaaa atagaaacgt tgatacatag tgagggatta aacaatggcc ggttatacgc 1775761 ctatgataca gcaatattta aaaataaagg cagagcacca ggatgccttt ttattttttc 1775821 gcctgggtga tttttatgaa atgttttttg aggacgccaa aaaagcgtca caagagctgg 1775881 aaattacgtt aacgagcaga gacggcggtg cggctgaaaa aataccgatg tgcggtgtgc 1775941 cgtatcattc tgcttccgcg tatatcgaac agcttattaa aaaaggatac aaagtggcga 1776001 tctgtgaaca gacggaagat ccgaaagccg caaagggcgt tgtgaaaaga gaagtagttc 1776061 agctgattac gcccggaact gtaatggacg gcaaaggcat ccatgagtcg gaaaataatt 1776121 ttatcgcatc tgtttcagcc tgctcgaacg gatacggact tgctctgtct gatttaacaa 1776181 cgggagaaaa tttggctgtt ttgattgaac ggcttgaaga cgtcatatca gaaatttatt 1776241 cagtcggcgc acgggaaatc gtggtttcag gaagcttgga tgccgataca gtggcacagc 1776301 tgagagagcg gtgcggtgca acgatttcaa ttgaagacgg agaaacagac gaacacgtaa 1776361 cgatcattga gcacttaaat aatgaagata taacaaaaac atttctgcgc ttatatacgt 1776421 atttgaaaag aacccaaaag cgcagccttg atcatcttca gcccgtgcag gtgtatgagc 1776481 ttgaggaagc gatgaaaatt gacttgtact caaagcgtaa tctggagctg accgaaacga 1776541 ttcgttcgaa aaataaaaaa ggctcccttt tgtggctgct ggatgaaaca aaaacggcaa 1776601 tgggaggccg gctacttaaa cagtggattg accggccgct tatcagagtc aatcaaatcg 1776661 aagagcgcca agaaatggtg gaaacattaa tgtcccattt ctttgaacgg gaagatctgc 1776721 gtgaacgttt aaaagaagta tatgacttag aacgccttgc cggccgcgtt gcattcggaa 1776781 atgtcaatgc ccgggatttg attcagctga aggaatcgtt aaagcaagtg cctggcatca 1776841 aacagctggt tgcttcactg gctcatgaca aggccaagga acgtgcaaag cgcattgacc 1776901 cttgcgggga tgtacttgaa ctgctggaag aagcgctgta cgaaaaccct cctttatcgg 1776961 taaaagaagg gaacctgatt aaagatggtt ataatcaaaa gcttgatgaa tatcgtgatg 1777021 caagcagaaa cggaaaagac tggattgccc gcctggaaca gcaggagcgg gaatacacag 1777081 gcattcgctc tttaaaggtc ggctttaata aagttttcgg ttattacatt gaagtgacaa 1777141 aagcaaactt gcatttgctt gaggaagggc gttatgagcg gaagcagacg ttaaccaatg 1777201 cagagcgcta cattacacct gaattaaaag aaaaagaagc gctcatttta gaggcggaaa 1777261 ataacatctg tgagctggag tacgagctgt ttaccgagct gcgcgagaaa gtgaagcagt 1777321 atattccgcg gctgcagcag cttgcaaaac agatgagcga gctggacgca ctgcaatgct 1777381 ttgcgacaat cagtgaaaat cgccactaca cgaaaccaga gttctctaaa gatgaagtcg 1777441 aagtgattga aggcagacac ccggttgttg aaaaagtcat ggacagccag gaatatgtcc 1777501 cgaacaactg tatgatgggc gataacagac aaatgcttct cattacaggt ccaaacatgt 1777561 cagggaaaag cacgtatatg agacaaatcg cgctcatttc cattatggcg caaatcggct 1777621 gctttgtacc cgcgaaaaaa gcggtgctcc cgattttcga tcaaattttt acgcgaatcg 1777681 gcgctgcaga tgatttgatt tccggacaaa gtacatttat ggtagaaatg cttgaagcga 1777741 aaaatgcgat tgtcaatgcg acgaaaaaca gcctcattct gtttgatgaa atcgggcggg 1777801 gaacgtccac ttatgacggc atggcgctgg cacaggcgat tattgaatat gttcacgatc 1777861 atatcggcgc caagacgctg ttcagcacac actatcacga gctgaccgtt cttgaggaca 1777921 agctgcccca gctgaaaaac gttcatgttc gcgctgaaga atataacgga acggttgtct 1777981 ttcttcatca aattaaagaa ggtgcggctg ataaaagcta tggtatccat gtagctcagc 1778041 ttgccgaact gccgggagat ctgattgcgc gcgctcaaga tattttaaaa gagcttgagc 1778101 attcaggaaa caaaccggaa gtgccggtgc agaaacctca ggtgaaagaa gagccggcac 1778161 agctgtcctt ttttgacgaa gcggaaaagc cggctgaaac accaaagctt tcaaaaaaag 1778221 aaaagcaagt gatcgatgct ttcaaatcac ttaatatact ggatatgaca ccgcttgaag 1778281 cgatgaatga aatgtacaag ctgcaaaaga aattacatta aaacggggtg atgaatgtgg 1778341 caaaagtcat ccaactgtca gatgagcttt caaataaaat agcggcgggc gaggttgtgg 1778401 aacggcccgc ctcagtcgtc aaagaattgg tggaaaatgc gatcgacgct gacagcacag 1778461 tcattgaaat cgatattgag gaagcaggcc ttgcatccat tcgggtcttg gataacggcg 1778521 aaggaatgga gaatgaagat tgcaagcgag ctttccggcg ccacgcaacg agtaaaataa 1778581 aagatgaaaa tgatttattc agggtgagaa cgctcggttt caggggagaa gccctgccga 1778641 gtatcgcgtc agtctctcat ctggagatta caacaagcac tggtgaagga gctgggacga 1778701 agctcgtcct ccaaggagga aacatcattt ccgaatcgcg ttcctcaagc aggaagggaa 1778761 ctgaaattgt cgtttccaac ctgtttttta acacaccggc ccgtttgaaa tatatgaaaa 1778821 ccgttcatac agagcttgga aacattacag atgtggttaa ccgtattgct ctggcgcatc 1778881 cagaggtatc gatccgcctg cgccatcatg ggaaaaacct gcttcaaacg aacggaaacg 1778941 gagatgtgcg ccatgtactg gcagcgattt acggcacggc tgtcgccaaa aaaatgcttc 1779001 cgctgcatgt gagctccttg gattttgaag taaagggata tatcgccctc ccagagatta 1779061 cacgggcgtc gagaaactat atgtcgtctg tggtcaatgg ccgttacatt aaaaatttcc 1779121 cgctcgtcaa agcggttcat gaaggctatc atacgcttct gccgatcgga cgccatccga 1779181 ttacttttat agaaattacg atggacccga ttttagtcga tgtcaacgtg catccatcga 1779241 agcttgaggt ccggctcagc aaggaaacag agcttcatga cttaatacgt gacggaatta 1779301 aagatgtgtt taaacagcag cagctgattc ctagtgccca ggtcccgaaa aaatcagcac 1779361 ctgccatcaa aaatgagcag cagtttataa cctttgatga aaagcctccg gaaaaaaaag 1779421 ttccggaaaa atcgactgcg ccatcttatt caccgatgaa gctcagctca gtcgtaaaag 1779481 agccggttga tgcggaggaa aaattgcccc ctctccaatt tgatgctcct cctatcgttg 1779541 atcaggaaca aacccttgag gtgtccgatg tttcagcaga acagcctgaa acatttgagc 1779601 aggaatgcca tgaggaacag ccgcagccag cgtctgatcg ggttccaatt atgtacccga 1779661 ttggccagat gcacgggact tatatattgg cacaaaacga aaacggccta tatattatcg 1779721 accagcacgc cgcccaagaa cgtattaaat atgagtactt ccgtgaaaag gtgggggagg 1779781 ttgagcctga ggtgcaggag atgattgtac cgctgacgtt ccactactcc acaaatgagg 1779841 ctttgattat tgaacagcac aaacaagagc tcgaaagcgt cggtgtcttt ttagagtcat 1779901 tcggctctaa cagttacatc gtccgctgcc acccagcctg gtttccaaag ggagaagaag 1779961 cagagcttat agaagaaatc attcagcagg tgctcgactc caaaaatata gatattaaaa 1780021 aacttcgcga ggaagcggcg attatgatga gctgcaaagg ctccatcaaa gcaaatcgcc 1780081 acctcagaaa cgacgaaatc aaagcgcttc tggacgacct ccgaagcaca tcagacccat 1780141 ttacatgccc gcacggccgc ccgatcatca ttcaccactc gacatatgag atggaaaaga 1780201 tgttcaaacg cgtgatgtag cgggggtggt aggcattgat ccattctctg aatggatcaa 1780261 tgcttttttt gtactccttc gagtgtcaga ttataagaaa cggttgtaaa cgtgtgagca 1780321 gtgttaacgc attatacttc atggttcctc cgtataacaa aatttccatt tacaggcaat 1780381 tgggattaat gtatattttg ggtgaggggg tggaaacata tggcatgtgg tccgaagatc 1780441 attatctttt tggatgaact tgatgatcca aatgtgagaa tcattttaga atgcagaatt 1780501 taaattacaa cattgtgttt tgctccctgt tcgtgtgaac agggagattt tttcgtttat 1780561 ataactggtg atgtccaaat atagggtgtt atgaattttc catatctgcc atcggcttta 1780621 agctgcttct ctattaggct ggttatcaaa agcaagttca atgatagcca tgaaagctga 1780681 tatcacaaca agcaagacat ctggaatata aatagactgc ataaagtaat ctgcaaaaca 1780741 gatcgttata agattgctga taaaatacag tataaaagca aaaagtgcag tctttttcaa 1780801 tgaaagtgat tttgccaaaa tgatagagat aatctttgtg agtgggtcta tgattaaacc 1780861 tacagcaaag caggctaaaa taaataaagc taatgtttga ttggaagcgt atgtgatgcc 1780921 aagtatggag aataagcctt tcatcccgaa gaaaaagccg ccgaagatga ctgcaagcgc 1780981 gatggccgcg ataaaagtaa tagatacaat tccgattaat tttgatctca ggttaaaatc 1781041 tttagagtgc tcgttctgtt ctttttggtt catgtatgac actcccttca cctgcttact 1781101 catacaaaca gcacccttga atcagcccaa aatatctata agtctgtttt ctgacgaaaa 1781161 tagtatagca tattttaaca aaaccaaaaa aggccctttc cactggggaa gggccttttt 1781221 catcatgtta actcctgaga ttcgccgaag ctttctcttt ttttggccaa ataaaatagc 1781281 tggctgtaat gagaaagtca atgcctataa tgacagtcca cagtttaaga atgccgctca 1781341 acgcctcggt tcgggaagag tcattgataa aatagatcat ccctgccaat agtcccgcac 1781401 caattaagta ggccagcaca tgtcttagcc agcctttcgc accgtgcttg gcatggtcca 1781461 ttccaaaacg tttcagcggt tttgttcctt tttttgtcac ataatattga aacttttcat 1781521 ctgcccattg aatcatttgt ttcccataag cgatcgatat accgatgtaa acagctgcaa 1781581 tcccatgggc tgcggtcgct gaggctccgc ggtaaaggtc cacaccagtt gccgctaaca 1781641 agatcaaatc gataactgga gttaaggcaa ggaatagcag tcctaatgta tgtcgtttga 1781701 atacgtagcg tacagcaagc cccaaaacaa tgacaaccca aaacgcaatt tcacagaaaa 1781761 caatcatcca tgcgataccg ttcaatccat tcccctcttt tcaatacagt tgtattattt 1781821 aaataatatg ttaccatctt tgtttttgta acacaactgt attataaaaa ttgccctctc 1781881 atttttttct tgttacaata aagctatgcc aaaacaaatt gaccatgaga aaagaagaaa 1781941 acaaattgca gaagcaacgt ggcgcgtcat tttagaacga gggatggagg gagcatcagc 1782001 cagaaatatt gcaaaggaag caggattgtc attaggtgcg ctgcgccatt atttctctac 1782061 acaggatgaa ttgcttgctt ttgcaatgaa acttgtccaa gaaaaggtaa cggaccgaat 1782121 taaggacatt gcagtgaggg atttgctccc taaggaaaaa gtgttgcaaa ttttgcttga 1782181 aatggtccca acgaatgaag aaacgattag agagatggag gtttggtttg cttttactgc 1782241 ttacgccaga cataaaaagg atatgtttga tgcgagtcat gacgggattt tcagcggcat 1782301 gcggaatctg attgcctatt tagatgaatc cgatttactg aagcagaatg ctgataaaga 1782361 cattgaagct gagagacttt acgcgcttgt tgacggcttg gctttacatg ccatgcttga 1782421 ccctgtgcgc gtgaataaag accgaatcaa gcgggtcatt atgcagcatg tagagtcaat 1782481 ttgcgtggaa gatacacgtg agacacaaaa acgacatcct taaggcacta gtgtgaaaag 1782541 cgattcttgt tgggcatgcg tccaaaagag tcgctttttt attttcaaag aacaaggatc 1782601 tctgaaaaaa atggaaaaca atcatgctgt ttggtaaagt ggaatgaaag acggactgag 1782661 gggtgaacac tggtccatcg tttaagaact ttacatgata gggatggtat aaatgaatct 1782721 tacttacaag gtgcatccaa ttaaaacaag gtatcagggc tggacgaatt attgctatat 1782781 cattgaagat attgtaagca gatctgcaat tgttgttgat ccctcatggg aattgagtaa 1782841 gataaccact acactttccg aactcgaagc ggaattaaag gcagtcgcat tgacacactc 1782901 tcattatgat catgtaaatc tggtagaccc gctgacgaag atgtttaacg ctcaagttta 1782961 tatgtcgaaa aaagaaattg attattatca attccgatgc agaaatttaa ttagcctaga 1783021 tgatcatcag acgatcagca taggaaacac aagagcacag tgccttctca caccggggca 1783081 tacagccggc ggaatgtgtt atttgttttc tgagagtatt tttaccggag atacggtgtt 1783141 tacagaaggg tgcggcatat gtgaggatga tggcagctct gcggaagaga tgtttgatag 1783201 cattcaaaga ataaagtcgg aggtttcacc ccatgtacgg gtgtatcctg gtcactcatt 1783261 tggcaaatcg cccggccatt cgataaagga tctttatcag cataatattt actttcaaat 1783321 tgataagaaa gaatattttg tgaaatttcg cactcgtaaa aaccaaaaag gtatttttga 1783381 ttttaaataa tccttctgaa tctattatcc tatttttctt cgaatatcta aatgattttt 1783441 attttcgaaa atgattacat agaaggtgtt atttattttg aaaactcatt tgaaagaaaa 1783501 tgaagcgcat tatcatgata tggcgcccta tatgtaatcc gggtcttttt tcttatgttc 1783561 tgttatatct cctgatcctt tattcctcaa tggaaaaaag cagaaaaaca atggagcaaa 1783621 ctgtaggaaa aattaacttg acggataata tttacagagg ttaccatcaa catgaacatg 1783681 ctactattta tccggtcatc actattataa aatcatacag aagtgaaaca catctactaa 1783741 tcggaagggt ggctttgaga gaatgatcac atatgttttt ccaggtcagg gttcacaaaa 1783801 acagggaatg ggcagcggcc tattcgatga atttaaagaa ctgacggatc aggcagatga 1783861 gatcttagga tattctatca aacgtctttg cctggaaaat ccttattcca atttaaacaa 1783921 aacgcaattt actcagccgg cattatatgt ggtaaacgca ctaagctatc tgaaaaaaat 1783981 cagggatgaa gaagttaaac ctgactttgt cgccgggcac agcttgggtg aatacaatgc 1784041 gttatttgca gctgaagcct ttgattttga gacaggttta cagcttgtca gaaaaagagg 1784101 cgagctgatg agtctgataa gcaacggcgg tatggcagct gttatgggac taaatgaaga 1784161 gcaggttgca aaggctctga aagaatatca tttacatgat gttgatatcg ctaatgtgaa 1784221 tgccccatat caaattgtaa tttcaggaaa aaaagatgag attgaaaaag ccgcatctct 1784281 ttttgaaacg atgactgaag ttacaatggt actcccctta aacgtaagcg gcgcgtttca 1784341 ttccagatac atgaataaag caaaagaaga attcgaggag ttccttcatg ccttttattt 1784401 ttcgcctccg tctatcccgg ttatttctaa tgtgtatgcc aaaccgtata catacgaatt 1784461 catgaaacag acgctggctg atcaaattaa tcattcagtg aaatggactg acagcataag 1784521 ctacttaatg aaaaaaggcc atatggagtt tgaggaggta gggcctggaa atgttttaac 1784581 tgggttaatt catcgcataa agaaagatgc ggaagcaatg ccccgctaaa gcatttgccc 1784641 ctatggccat gtatctcatc aatcaggtct aaacacagat ttcctttcat ttaaggtata 1784701 aagttttaaa gattcaatcg ttcgattgac actgtttcta attgaataac tttatatact 1784761 gttacataaa gaggctgata aattaagtta gacatttgaa ctatgtcagc cggtctgtca 1784821 aaccatcgct cccacatcta gatggtccat ttttaaaccg cacccaccaa tcatagagtc 1784881 gatgttcttt gctgatcctg ttatcatgtt acatcaattt tgagatatca acatacatct 1784941 acgatcacgt cataaatgaa ccacatccag agcaccaata gcaatccttc caagttgaat 1785001 ctcctttact ttttcacata tgtcttttcc atttattaat ttcatttcaa tcgctgctat 1785061 gtgctttaac aacatgcatg gaaatgagaa atccaatagc cgtcataaat ataaaaaaag 1785121 aaggttatac acatgaatga accgcttgtt tttatgtttt ccgggcaagg ttcccaatac 1785181 tatcacatgg ggaaagaact atttaaggaa aataccgtgt ttcgccaatc aatgcttgaa 1785241 atggatgcca ttgcagcacg gcgaatcggc acatccattg ttgaagaaat ctaccatcca 1785301 ggtaaacgtg tgtcagatcc gtttgacagt attctttttt cccaccccgc catttttatg 1785361 attgagtatt ccttatataa ggttttggaa gacaggggaa tttatcctga ttacgtattg 1785421 ggatcaagtc tgggagaatt cgcagcagcg gcagtttctg gtgtgtcaga cgcagaggat 1785481 atgctggatt gcatacttga acaggctatt atcatccaga attcctgcga taaaggaaaa 1785541 atgctggcca ttcttgacaa accgcaattg ctgaatgatc atccgcaact gtttggaaat 1785601 agtgaactca tttctatcaa ttatgattcg cacttcgtca tttctggtga agaagatcat 1785661 ataaggaaga ttatggagga tttaaaggag aagcagattc tttgccagct gcttcctgtg 1785721 tcctatgcct ttcattcttc gcttattgat ccggcagaga gtgcctatgc agaattttta 1785781 agatcaaaat cttttcaaaa accgtcaata ccgattgtat cgagcttaac gggaagctgc 1785841 cttcacgtaa tggacgagaa tttcttttgg aatgcggtca gaaagccaat gatgtttcgt 1785901 gaagcgattc gatatttgga aagccagcat acatgcaagt ttatcgattt agggccatcc 1785961 ggcaccttag ctgcttttgt gaaacagctg attccgggtg attcagctga ccgttgctgc 1786021 tcaatcataa caccatttca tcaggagctg aaaaatctga atacggttga gtatttccgt 1786081 acaccagaaa ggaagtttac aagatgatta catatgtctt tccagggcaa ggctcccagc 1786141 aaaaggggat gggacaaggg ctatttgaac agtatcagca tttgacagat caagcagatc 1786201 aaatattggg ctattcaata gagaagctat gtaccgaaaa atcatatctg gatgtaaatc 1786261 atactgaata cacgcagccg gctttgtatg ttgttaatgc actcagttac ttgaagagag 1786321 tggaggagac cggcagaaaa cctgattttg cggcaggaca cagcttagga gaatacaatg 1786381 cgctgatggc agccggtgca tttgattttg aaaccggatt aaggctcgtc aaaaaaagag 1786441 gagaattgat gggacgaatt acagggggcg gaatggctgc tgtgatcggc ctgagtaagg 1786501 aacaagttac agccgtttta gaagagcacc gtctttatga cattgatgtg gcaaatgaaa 1786561 atacgcccca gcaaattgtg atttctggcc cgaaaaaaga gattgaaaaa gctcgggctg 1786621 tttttgaaaa caccaaggat gtaaagctgt ttcatccatt aaatgtgagc ggagcttttc 1786681 attccagata tatgaatgaa gccaaacagg tatttaagca atatattgac tcattccagt 1786741 ttgcaccttt ggcgatcccg gttatctcca atgtctacgc agagccatac catcaagaca 1786801 gattaaaaga tacattatct gaacaaatgg acaacacagt gaaatggacg gacagcattc 1786861 gttttctgat gggaagagga gaaatggagt ttgcagagat tgggcctgga actgttttaa 1786921 ccggtctcat tcatcggatt aaaaatgaag ctgaaccatt gacatatata ccgaaaaaga 1786981 accccgcgat cagtgcgcat ctaaaggagc aacgcaatgt tcaagccggg attacggcag 1787041 aatctttagg aagtgctgaa tttaaacaag attatcatct tacatatgct tatcttgcag 1787101 gaggaatgta ccgcggcatt gcttcgaaag aaatggtagt aaagctgtca agagcgggaa 1787161 tgatggggtt ctttggcaca ggaggtctga gcctgaaaga ggttgaagat gcgatccatg 1787221 ctatacaagg tgaattagga aaaggacaag cctacggcat caatctggtc cacaatatga 1787281 aacatactga atcagaagaa aaaatgatcg atcttttatt gaggaatcaa gtgagcattg 1787341 tggaggcttc agcattttta agtgtcactc ctgtattagt aaggtatcgc gcaaaaggag 1787401 tgaaacgaaa tcaaaatggt gacgttatat gctcaaatcg tctcatagca aaaatatcac 1787461 ggccggaagt tgcagaatca tttctgagtc ctgcgcctga gaatatgctg caaaagcttt 1787521 taggagaaaa taaaatcact atgaacgaag ctgagttgtt gcggtgcatt ccgatggctg 1787581 acgatatttg tgtagaagct gattcaggcg gtcatacaga tggcggtgtg gcatacagcc 1787641 tgatgccggc gatgacatct ttaagagatg aaatgatgaa aaaatatcaa taccggaaaa 1787701 aaataagagt tggtgcagct ggaggaattg gaacacctga ggcagcgatg gcggctttta 1787761 tgctaggggc tgattttatt ctaacaggct caatcaatca atgtacggtt gaggcggcaa 1787821 caagtgataa agtaaaggat ttgcttcagc agatgaatgt acaagataca gcctatgcgc 1787881 ctgcaggtga tatgtttgaa tcgggcagta aagtgcaggt gctaaagaaa ggcgtgttct 1787941 ttcccgcacg ggcaaacaag ttatatgaac tgtatcagcg gtatgggtct atacgtgagc 1788001 tggatgcaaa gatgctggcc cagcttgagg agaaatactt taaacgcagt atagaagaca 1788061 tatataaaga tattgcattg cattatcccg cggcagacat tgagaaggct gaacaaaacc 1788121 cgaagcataa aatggctttg attttccgat ggtacttcag atacagttca aaattggcaa 1788181 tcagcggaag cgaacattcg aaggtcgatt atcaaattca ctgcggtccc gcgctgggag 1788241 cctttaatca atgggttaaa gggtcgcaat tagaaaattg gcgaaaccgc catgtggatg 1788301 aaatcgggaa aaaattaatg acagaaacgg cagtattgct tcatgaacgg atgcaatcga 1788361 tgtatcagcc gtcgcatgaa acagacaaca taaaaataaa agtttgaata ttatgaaaat 1788421 atacctataa aaatcattaa aataatccct tgaaggagag agcgcattat ggataaacag 1788481 agaatctttg aagtattaat caccaatatt tgcgaggtgc ttcctgaatt agacggacac 1788541 agatttgagc ctgaagatca gttagttgag ctaggagctg actctgtaga cagagctgaa 1788601 attatcacga tggtgctaga ggatttatcg ttaaaaatcc ctcgcattga gctatccggg 1788661 gtgaaaaaca tcggtgaatt agctgaggtg ctttatgaca aagtgcaatc tgcctgaggt 1788721 ggtggtgacc ggtgtaggcg ttacggcctc tatcggtcaa gggaaagagg actttgcttc 1788781 ctcgctgctg tccggcagac atgcctttga tgtcatgaag cgttcaggca gacaaaaaga 1788841 cagccggttt atcggagccg aaattgcgtc attgtcttat cctgaccgac tctctaaaaa 1788901 aatgttgcga aaagcatcat tctccagccg cgctgcattg gtaactctca cagaggcttg 1788961 ggaggaggct gaattggacg atgcagattc ctcacgtatc ggactggttg ttggcggatc 1789021 aaattttcaa cagagagaaa actttgaagt ttatgaaagg tatcaagacc gctccggttt 1789081 tatttctccg gcgtatggtc tgtctttcat ggacagcgat ctttgcggga tatgtacaga 1789141 tcagtttggc atcacgggat tagcatatac ggtgggagga gcttcggcca gcggccagtt 1789201 agcagtcatt catgcgattc agcaagtcct gtcaggcgaa gttgatactt gcatagcact 1789261 tggtgcttta atggatcttt cttatatgga atgcgaggcg ctaagggctt taggcgctat 1789321 ggggacggac aaatatgctg atgaacctga aaatgcgtgc cgtcccttcg atcaaaacag 1789381 agacgggttt atctatggag aatcgtgcgg tgcattggta atagaacgaa aggagacggc 1789441 tttacgaaga ggtctaaaac cttatgcagc attgtctggc tggtcaatca aactggacgg 1789501 aaaccggaat cctgatcctt cattagaagg agagattcat gtcatccaga aggcactgga 1789561 gcgtgccagg cttttaccag aagatattga ttatattaat cctcatggaa caggctcttt 1789621 tattggagat gaaatagaat taaaggcgct ccgtgcatgc cggctttccc atgcttatat 1789681 caatgcaaca aaatcgataa ccggacacgg gcttagtgcg gcgggcatcg tagagattat 1789741 ttctgttttg ctgcaaatga aaaaatctgc cctgcatccg agcaggaatt tggatcatcc 1789801 aatcgatgat tcctttcatt gggtaaatga gaaatcgatt tcataccgca tcaaaaatgc 1789861 gctgagctta agcatggggt ttggcggaat gaacaccgcg gtttgtatac aaaacattga 1789921 gaaatgtgga ggcgaatcat aaatggtttc agccggaata gaagcgatga atgtctttgg 1789981 cggaacggca taccttgatg tcatggagct ggccaaatac agacacttag atactgcgag 1790041 atttgaaaat ttattaatga aagaaaaagc ggtagcactg ccttatgaag atcccgtgac 1790101 cttcggagtc aatgcagcta agccgattat tgatgcttta tctgaagcag agaaggaccg 1790161 gattgaattg ctgatcactt gctctgaatc cgggatcgac tttgggaaat cgttaagtac 1790221 atatatccat gaatatttag gtctcaaccg caactgccgt ttgtttgagg ttaaacaggc 1790281 gtgttattca gggacagcgg gatttcagat ggcggtgaat tttatattat cccagacttc 1790341 tccgggtgcc aaagcactgg ttatcgccag tgatatttca cgttttttaa tcgctgaggg 1790401 cggagacgct ttaagcgaag attggtctta tgcggaaccg agcgccggag cgggagcggt 1790461 ggccgtttta gttggcgaaa atcccgaggt gtttcaaata gatcccggag caaatggtta 1790521 ttacggctat gaagtgatgg acacgtgccg ccccattccc gacagtgaag cgggagattc 1790581 tgatctgtct ttaatgtcat atttggattg ctgcgaacag acttttctgg aatatcaaaa 1790641 gcgtgtaccg ggtgccaatt atcaggacac gtttcaatat cttgcttacc atacgccctt 1790701 tggcgggatg gtgaaaggtg cgcaccggac aatgatgcgt aaggtagcga aggtgaaaac 1790761 atccgggatt gagacggatt ttttaactcg ggtaaaacca ggtttaaact actgtcaacg 1790821 ggttggaaat attatggggg cagccttgtt tctggcattg gccagcacga tagaccaagg 1790881 gagatttgat acgcctaaac gaattggctg tttttcctac ggatccggct gctgttctga 1790941 attttacagc ggaattacaa ctccgcaagg ccaggagcgt cagcgaacat ttggtattga 1791001 gaagcatttg gatcgccggt atcagctctc catggaagag tatgagctat tgtttaaggg 1791061 gagcgggatg gtgcggtttg ggacgcgcaa tgtaaagctg gactttgaga tgataccggg 1791121 catcatgcag tccactcaag agaagccgcg cttgttttta gaagaaattt ctgagtttca 1791181 tcggaagtac aggtggatct cgtgacctat caaacgataa aggtccgctt tcaagcatcg 1791241 gtttgctata ttacctttca ccgtcctgaa gcgaataata cgattaatga cacgctgata 1791301 gaagaatgct tgcaagtgtt aaaccaatgt gaaacatcaa cggtgacggt tgtcgtttta 1791361 gaggggcttc ccgaggtgtt ttgtttcgga gcggattttc aagaaatcta tcaggaaatg 1791421 aaaaggggca gaaaacaggc aagctcccaa gagcctctct atgatttgtg gatgaaattg 1791481 cagaccggcc cttatgtcac gatttcgcat gtcaggggaa aagtgaatgc cggcggtctt 1791541 ggatttgtat ctgccacaga tattgccatt gctgatcaga cggcgtcatt cagtctctct 1791601 gagctgctat tcggcctgta ccctgcttgt gttttaccgt ttctgatccg ccgtatcggc 1791661 cggcagaaag cgcattatat gacgcttatg acaaagccga tttccgttca ggaagccagt 1791721 gaatgggggt taatagatgc ttttgatgct gaaagtgacg tgctgctgag aaagcattta 1791781 ttgcgtttgc ggaggctgaa taaaaaagga atcgcacatt ataaacagtt tatgagctca 1791841 cttgatcatc aagtcagtcg tgcgaaagcc accgctttaa ctgcaaatca agacatgttt 1791901 tctgatcctc aaaaccaaat gggaatcatc aggtatgttg aaacaggaca attcccatgg 1791961 gaggatcagt aaccgtttaa aaatgacaat cagaaccgtt aggaggacat catgacgcat 1792021 tctgttgtag agcttatcga aattgaatcc gccattattc aggtaaagat gcaagatcgc 1792081 actcataaaa acgcgttttc acaagaactt acagacgatt taattcaagc gtttgaatac 1792141 atacggcaga atcccaaata caaagcggtc attttgacag gatatgataa ttattttgct 1792201 tcaggaggaa cgcaagaagg actgcttcga attcaacagg gattgaccaa gttcactgat 1792261 gacaatcttt attctctggc gctggattgc gagattccag ttattgcggc aatgcagggc 1792321 catggaattg gaggcggctt tgtcatgggg ctctttgctg acattgtcat tctgagcaga 1792381 gaaagcgtgt atacggctaa ttttatgaaa tacggattta cgcctggaat gggcgctacc 1792441 tttatcgttc ctaaaaaact gggtttcagc ctggcccagg aaatattatt gaatgcgggc 1792501 agctaccgcg gagctgatct tgaaaaaaga ggggttcctt ttaaggtgct gccccgtgca 1792561 gaagtgttag attatgcagt ggagctggcg caagaactgg cggaaaagcc gagaaactca 1792621 ctggttacac tgaaagatca tttggttgcc ccgcttcgcg atcagctgcc gcgcgtcatt 1792681 gaacaggaat tgatgatgca tgagaaaaca tttcatcatg aagaagtcaa aagtagaatc 1792741 aaaggtttat atggtaatta actgaaaata tatataaatt ttgcaggtga aatggaggca 1792801 gcgtgatgag aaataatgat aatatccgca tattaactaa tccttctgtc agtcatgggg 1792861 agcctttaca tatatctgaa aagcagccgg caacaatacc tgaagtttta tacagaacgg 1792921 cgacggagct tggggataca aagggaatca tttatttgca gccggatgga actgaagttt 1792981 accaatcata cagacgatta tgggatgatg gattgcgcat tgcgaagggg cttcgccaat 1793041 caggcctgaa agcaaaacaa agcgtgattt tgcagcttgg tgacaattca cagcttctcc 1793101 ctgcgttctg ggggtgtgtg ttaacagggg ttgttccggc tccattagcc gttccgccaa 1793161 cgtatgctga atcgagcagc ggcactcaaa agctgaaaga cgcatggacg cttcttgata 1793221 agccagcggt gattacggac cgggggatgc atcaggaaat gctcgattgg gcaaaagaac 1793281 aagggcttga agggttcagg gcaattattg tagaggatct gctcagcgct gaagcggaca 1793341 cagattggca tcaatccagt cctgaagact tagcgctttt attgctgact tcaggcagta 1793401 cgggaacgcc caaagcagtt atgcttaatc atcgtaacat tatgagcatg gtgaaaggga 1793461 ttattcaaat gcaaggcttc accagagagg atattacgtt taactggatg ccgtttgacc 1793521 atgtcggagg gatcggaatg ctgcatttgc gggatgttta tcttggctgt caggaaatta 1793581 acgtctcaag cgaaacgatc ttaatggagc cgttgaaatg gctggattgg attgatcatt 1793641 accgagcttc tgttacgtgg gcgccgaatt ttgcgtttgg tctggttact gattttgcag 1793701 aagaaataaa agataagaaa tgggatctgt cttcaatgcg atacatgctc aatggcggtg 1793761 aagcaatggt agccaaggta gggcgtagaa tacttgagct tttagaacca catggactgc 1793821 ctgctgacgc catccgacct gcctggggaa tgtccgaaac ttcatcgggc gttatttttt 1793881 ctcatgaatt tacccgggct ggaacaagtg atgatgatca ttttgttgaa ataggctctc 1793941 caatccccgg cttctctatg agaattgtga atgaccataa tgaattggtt gaagagggtg 1794001 agatcggccg ttttcaagtc tcgggtcttt ctgttactag cggttattac cagcggcctg 1794061 atttgaatga gagtgtgttt acagaagacg gctggtttga aaccggagat cttggctttt 1794121 tgcgaaacgg gcgcttaacc ataacaggcc gtacgaaaga tgcaattatc attaacggca 1794181 ttaattatta cagtcatgca attgagtctg cagttgaaga attacctgaa attgaaactt 1794241 cttatactgc tgcttgcgct gtccgtctgg gccagaattc aacagatcag ctggctatct 1794301 tctttgttac ttccgcaaaa ttaaatgatg agcagatgtc tcagcttctt agaaacatac 1794361 aatcccatgt ctcacaggtg atcggagtca ccccggaata tttgctgcct gtacaaaaag 1794421 aagagattcc aaaaacggct atcggaaaga tccagcgcac ccagctaaaa acttcatttg 1794481 aaaatggaga gttcgaccac ttgctacata aacccaatcg gatgaacgat gcagtccagg 1794541 atgaggggat acagcaagca gaccaggtga aaagagtaag ggaagaaata cagaagcatc 1794601 tgctcacctg tttgactgag gagctgcacg tttcccacga ttgggtggag ccaaatgcaa 1794661 atatccaaag tcttggtgtg aattctatca agatgatgaa gctcattcga tcgatcgaga 1794721 aaaactatca tatcaaacta acagctagag agatacatca atatcctaca attgaacgct 1794781 tagccagcta tctatcagaa catgaagacc tcagcagctt gtctgctgac aaaaagggca 1794841 cggacacata taaaaccgaa ccggaaagga gtcaggcaac ttttcagcct ctctctgagg 1794901 ttcaaaaagg attatggaca ttgcaaaaaa tgtcacccga aaaaagtgca tatcacgtac 1794961 ctctctgttt taaattttcg tcagggcttc accatgaaac attccagcag gctttcggcc 1795021 ttgtattgaa tcagcaccca atcttaaagc acgtcatcca agagaaagac ggagtgccat 1795081 ttcttaaaaa tgagccagca ctttcaattg aaatcaagac agaaaatatc tcaagtttga 1795141 aagagtctga tattcctgct tttcttagaa agaaagtaaa ggaaccgtat gtaaaggaaa 1795201 acagcccgtt agtgcgtgtc atgagctttt ccagatctga acaagagcat tttttattag 1795261 ttgtcattca ccatttgatt tttgacggag tttcgtctgt cacatttata cgcagtctgt 1795321 ttgataccta tcagcttctt ttaaaaggac agcagccgga aaaagctgtt tctcctgcca 1795381 tttatcatga ttttgcggca tgggagaaaa acatgcttgc cggcaaagac ggtgtgaagc 1795441 accgtacata ttggcagaaa cagctatcgg gaactttgcc gaatcttcag ctgcctaatg 1795501 tcagcgcaag ttcagtcgat tctcagttta gagaggatac atacaccagg cggttgtcca 1795561 gcggcttcat gaatcaggtc agaacgtttg cgaaagagca ttctgtaaat gtcacgacgg 1795621 tattcttaag ctgctatatg atgctgcttg gccgttacac aggccaaaaa gaacagatcg 1795681 tcggcatgcc ggccatggtg aggccggaag aaagatttga tgatgccatt ggacattttc 1795741 tcaatatgct cccgattcgg agtgagctga acccggcaga cactttttct agctttatat 1795801 caaaattgca attaacgata ttggatgggc ttgatcatgc agcatatcct tttccaaaaa 1795861 tggtgaggga tctgaatatt cctcgcagtc aagcaggttc accggtattt caaaccgctt 1795921 ttttctatca gaattttctt caatccggaa gctatcaaag cttgctgagc cgctatgctg 1795981 acttcttttc tgtcgatttc gttgagtata ttcaccaaga gggcgaatac gaattagtat 1796041 ttgaactgtg ggaaacagaa gaaaaaatgg agctgaacat caagtacaat actgggctgt 1796101 ttgatgcggc ttctatatcc gccatgttcg accattttgt ttatgtaaca gagcaggcga 1796161 tgttgaatcc ttctcagcct ttaaaagagt attctttatt acctgaggca gagaagcaga 1796221 tgattctcaa aacatggaac gccacaggaa aaacgtatcc atatataact tttcatgagt 1796281 tgtttgagca gcaggcgaaa aagacgcctg atagagcggc tgtcagctat gaaggtcaaa 1796341 cattgacgta tcgggagctt gatgagaaaa gcacacagct ggccatttat ttgcaggcgc 1796401 atggagtggg tcctgaccgt ctggcgggga tctatgtgga tcgatcgctg gacatgctag 1796461 tgggtttatt agcgatcctc aaggctgggg gagcgtatgt gccgctagac ccgtcctatc 1796521 cggctgaacg attagaatac atgcttgagg acagtgaagt tttcattaca ctgacgacat 1796581 cggaattagt aaatacgttg agttggaacg gtgtcacaac agccctttta gatcaagatt 1796641 gggatgaaat tgctcaaaca gcctctgatc gaaaagtgct tacacgcact gtcacgccag 1796701 agaacttggc atatgtcatt tatacatccg gcagcacagg aaagccaaaa ggtgtcatga 1796761 taccacataa agctttgaca aactttctcg tttcgatggg ggaaacacca ggtcttacgg 1796821 cagaggataa aatgcttgct gtcacaacct actgttttga tattgcagct ctggaattat 1796881 ttttgccttt aataaagggc gcacactgct atatttgtca aacggagcat acaaaagacg 1796941 ttgaaaaact gaaacgggac atccgcgcga tcaaaccgac agtgatgcag gcaacccccg 1797001 ctacgtggaa gatgctcttt tattcaggct gggaaaatga agagagcgtg aaaattttat 1797061 gcggtggcga agcattgcct gagacattaa aacgatattt cttagatacg ggcagcgaag 1797121 cctggaatat gttcgggcca accgaaacaa ctatctggtc agcggttcag cgcattaacg 1797181 ttgaatgctc tcatgccacg ataggaaggc caatcgccaa tacacaaatc tatattacgg 1797241 attctcagct cgcgccagtg ccggcaggtg ttccgggtga gctgtgcatt gcaggagacg 1797301 gtgtggcgaa gggctactac aaaaaggaag aattaacgga ttcgagattc attgacaacc 1797361 cttttgagcc tgggtctaag ctttatagaa cgggagacat ggcccgttgg cttacgggag 1797421 ggcgaattga atatataggc cgcatcgata atcaagtaaa aatccgcgga ttccgtattg 1797481 aacttggtga tattgaaagc aggcttagtg agcatcccgg cattctggaa tgcgttgtgg 1797541 tcgcagatat ggataaccta gctgcctatt atacagctaa acatgcaaat gcttctctca 1797601 cagcgagaga gctgcgtcat tttgtgaaaa acgctttgcc tgcctatatg gtgccttctt 1797661 attttattca gcttgatcat atgccgttaa ctccgaacgg aaagatagat agaaacagcc 1797721 ttaagaatat cgatttatca ggggagcagc taaagcaaag gcagacctct cctaagaaca 1797781 ttcaggatac tgtttttacc atttggcagg aagtgctgaa aacgagtgac attgaatggg 1797841 atgacggatt tttcgatgtg ggcggggatt cgcttctcgc ggtcactgtg gctgatcgta 1797901 tcaaacatga actatcctgt gagttttctg tcacagacct gtttgagtat tcaacgatta 1797961 aaaatatcag ccagtacatc actgaacagc gaatgggcga tgcaagtgac catataccga 1798021 cagacccggc agctcatata gaagatcagt ctaccgagat gagtgatctc ccggactatt 1798081 atgacgatag tgtggcgatt attggcatat cgtgtgaatt tccaggggca aaaaatcatg 1798141 atgaattttg ggagaacctc agagacggca aggaaagcat tgcgtttttc aataaagaag 1798201 agcttcagcg ctttggcatt tcaaaggaga tagcggagaa tgccgactat gtccctgcta 1798261 aagcttcaat tgatgggaaa gacagatttg atccaagctt ctttcaaatc tctcctaaag 1798321 acgctgaatt tatggaccct cagcttcgga tgctgctgac tcattcatgg aaagcaatag 1798381 aagatgccgg ttatgctgcg aggcagattc cgcaaaccag tgtttttatg tcggcaagca 1798441 ataattctta tcgcgcgctg ctgccgtcag atacaacaga gagcctggag acgccggacg 1798501 gctatgtttc gtgggtgctt gcacagagcg ggacgattcc gacaatgatt tctcataagc 1798561 tcgggctgag agggccaagc tattttgtcc atgccaactg ctcatcctct ctgattggat 1798621 tgcattctgc ctataagagc ctcctgtcgg gtgaatctga ttatgcttta gttggcggtg 1798681 caacgctgca taccgagtca aatatcggat atgtgcatca gcctgggctg aacttttcga 1798741 gtgatggaca tattaaagct tttgacgctt cagctgacgg aatgataggc ggtgagggcg 1798801 ttgctgttgt attgctgaaa aaagcagctg atgcagtaaa ggacggggat catatctatg 1798861 ccttgctgag aggcattggt gtaaataacg acggcgctga caaagtcggc ttttatgctc 1798921 caagcgttaa aggccaggct gacgtggtcc aacaggtcat gaatcaaacg aaggtacagc 1798981 ctgaatccat ctgctatgta gaagcacacg ggaccggaac gaagctgggg gacccgatcg 1799041 agctggcggc tttaacaaac gtttacaggc aatatacaaa taaaacgcaa ttttgcggca 1799101 ttgggtcggt gaaaaccaat atcggacatt tagatacagc cgccggtctt gcgggctgca 1799161 ttaaggttgt gatgagtctt tatcatcaag agcttgcacc gagtgtcaat tataaggagc 1799221 cgaatccaaa tacagactta gccagctctc ctttttacgt cgtcgatcaa aagaaaacgt 1799281 taagccgtga gatcaaaacg cacagggctg cacttagctc gttcgggctt ggcgggacaa 1799341 atacccatgc catttttgaa caattcaaaa gggattcaga taagggaaag atagacggaa 1799401 cctgcatcgt cccgatctcg gcgaaaaata aagagaggct gcaagagtat gcagaagaca 1799461 ttctggccta tttagaaaga agagggtttg agaacagcca gctgcctgat tttgcgtata 1799521 cccttcaggt ggggcgcgaa gcgatggagc atcgcgttgt ctttattgcc gatcatgtaa 1799581 atgagttaaa acagaggctc acagatttta tcaatggaaa tacagcgatt gaaggctgtt 1799641 ttcaaggaag taagcacaat gccagagagg tttcatggct gacggaggat gaggacagcg 1799701 ctgaactcat acgtaagtgg atggccaaag gaaaagtaaa caagcttgca gaaatgtgga 1799761 gcaagggagc gcatatagat tggatgcagc tttacaaggg agagcgccca aacagaatga 1799821 gtctgccgac ttatccattt gcaaaggaac gatactggcc gtcgcaggat gaccgcaaac 1799881 cggtggcgca gatatccgga aatcagacag ggatcggctc tattcatcca ttgcttcatc 1799941 agaatacatc tgatttttct gaacagaaat tcagttcggt tttcactggt gacgaatttt 1800001 tcctgagaga ccatgtggta agaggaaagc ctgtgcttcc tggtgttgcg taccttgaaa 1800061 tggcgtacgc ggctataaac caggcggcag gaagtgaaat tggccaagat gtcagaatca 1800121 gattgaatca tacagtctgg gttcagcctg ttgtggttga cagacattca gctcaagtgg 1800181 atatcagtct ctttcctgaa gaagatggaa aaatcacctt tgacatttac agtacacagg 1800241 aagacgggga cgaccctgtt attcatagtc aaggcagtgc ggagctggca tctgccgccg 1800301 aaacgccagt cgcagatctc actgaaatgt cacgccgttg cggcaaagga aagatgtcgc 1800361 ctgatcaatt ttacgaagaa ggcagaagca gaggaatgtt ccatggtccg gcctttcaag 1800421 gaattaagaa tgtgaatata ggaaacagag aggttttggc gcagctgcag cttccagaaa 1800481 tcgtttctgg aacgaatgaa cagtttgtgc tgcacccaag tatcatggat tccgccttgc 1800541 agacagcaac aatatgcatc atgcaggaat tgacggatca aaagctgatt ttgccatttg 1800601 cgcttgagga gcttgaagtg atcaaagggt gttcttcttc tatgtgggct tatgcccgct 1800661 taagtgacag cgatcactcc ggaggggttg ttcagaaagc ggatatcgat gtcattgacg 1800721 agagtggaac cgtatgtgtc aggatcaaag gattttcaac gagagtatta gaaggggagg 1800781 ttcatacttc aaagccttca acacggcacg aacgcttaat gcttgaaccg gtgtgggaaa 1800841 aacagaatga agaacgagag gacgaagatc tttcgtacac ggagcatatc attgttctct 1800901 tcgaaactga acgaagtgtc acagacagca ttgcctccca catgaaagat gcccgtgtga 1800961 ttactctaaa cgaagctgta ggacatattg ctgaacgtta tcaatgttac atgcagaaca 1801021 tttttgaact cctgcaaagc aaggtccgta agctttctgc aggccgtatc atcattcaag 1801081 cgattgttcc gctggaaaaa gagaagcaat tgtttgccgg cgtttccggt ctgtttaaaa 1801141 cagcagaaat agagttcagc aaactgactg ctcaggtcat cgaaattgag aaacctgaag 1801201 agatgataga ccttcacctc aagctgaaag acgacagccg gagaccattt gacaaacaga 1801261 ttcgatatga ggctggatac cgttttgtga aaggctggag ggaaatggtg cttccttcag 1801321 ctgatacgct tcacatgccg tggagagacg agggtgttta tctaatcaca ggcggagcag 1801381 gaagcttagg ccttctgttt gcaaaggaaa ttgccaatcg aactggccgg tctactattg 1801441 tgctgacggg acgatctgtt ttaagtgagg ataaggaaaa cgagctggag gctcttcgaa 1801501 gcatcggagc ggaggttgtc tatcgagagg ctgatgtaag tgatcagcat gcggttcgtc 1801561 atcttttgga ggaaatcaaa gaaagatatg gcactctcaa tggaattatt cacggtgcag 1801621 gcagcagtaa agatcgcttc atcattcata aaacgaatga agagtttcaa gaagtgttgc 1801681 agccaaaagt gagcgggttg ttacatgtag acgaatgcag caaggatttc ccattggact 1801741 ttttcatttt cttctcttct gtttcgggat gtttaggaaa cgctggacaa gccgattatg 1801801 cggcagccaa ttcgtttatg gatgcatttg ctgaataccg ccgttctctt gcggcatcaa 1801861 aaaagagatt cggctccacc atttccttca attggccgtt atgggaagaa ggcggtatgc 1801921 aagtcggcgc tgaagatgaa aagagaatgc tgaaaacgac gggaatggtc ccgatgccga 1801981 cagatagtgg cttgaaagca ttttatcaag ggatagtatc tgataagccg caagtttttg 1802041 tgatggaagg acagcttcag aaaatgaagc aaaaactgct ttccgcagga tcgaaagcca 1802101 agcggaacga tcagagaaag gcggatcagg atcaaggaca aactagaaaa ttggaagcag 1802161 ccttaatcca aatggttggc gcaattttga aagtaaacac tgacgatatc gatgtcaaca 1802221 cagagctgag tgagtacgga ttcgactcag ttacattcac tgtctttaca aacaagatca 1802281 acgaaaaatt tcaattggag ctaacaccga ccatattctt tgaatatggc agcgtccaaa 1802341 gcctggctga atatgtagtt gctgcgtatc agggcgaatg gaatcaagat gctactgcta 1802401 aaggcaaaga tgaaagaaca aacttagtgc acagtttaag cagcctggag gcatcattaa 1802461 gcaacatggt cagtgcaatt ttaaaagtaa atagtgaaga tattgatgtc aatacagagc 1802521 tgagtgaata cggatttgat tcagttacat ttacggtctt tacaaacaag atcaacgaag 1802581 aatttcagtt ggagctaacg ccgaccattt tctttgaata tggaagcctc cacagcctgg 1802641 ctgagtattt gaccgttgaa catggtgaca ccctggttca ggagcgagaa aaaccagagg 1802701 ggcaggaaga gttacagaca aaatcttctg aagcgccgaa aatcacatca cgtagaaagc 1802761 gccgctttac acagcctatt attgcaaaag cagaaagaaa caaaaagcag gctgccgatt 1802821 ttgagccggt tgcaattgtc ggcatcagcg gccggttccc tggcgctatg gatatagacg 1802881 aattttggaa aaacctagaa gaaggaaaag acagcatcac agaagttcca aaagatcgat 1802941 gggattggcg ggagcattat ggaaacccag acactgacgt caataaaacc gacatcaaat 1803001 ggggtgggtt tattgatggt gtcgcagagt ttgatccgtt gttttttggt atttcgccgc 1803061 gagaagctga ttatgtagac cctcagcagc gcttgttaat gacatacgtg tggaaggcat 1803121 tggaagatgc gggttgctcg ccgcaaagcc tttcgggtac agggaccggt atctttatcg 1803181 gtacgggaaa caccggttat aaagatctat tccatagagc gaatcttcca attgaaggcc 1803241 atgctgctac aggtcatatg attccttcgg taggcccgaa tagaatgagt tattttttaa 1803301 atattcatgg tccgagcgag ccagtagaga cggcttgttc cagttctctt gtagccattc 1803361 accgtgctgt gactgcgatg caaaacggtg attgtgagat ggcgatcgct ggaggcgtga 1803421 atacgatctt aaccgaggag gcgcatatta gctacagcaa ggcggggatg ctcagcacag 1803481 acggcaggtg taaaaccttc tccgccgatg cgaatggcta tgtcagaggc gaaggggtcg 1803541 gaatggtcat gttgaaaaag ctggaagatg ccgagcgcga cggaaatcat atttacggcg 1803601 ttattcgggg cacggcggaa aatcacggcg gaagagccaa taccctgaca tcgcctaatc 1803661 cgaaagcaca agctgatttg ttggtgcgtg catatcgcca agcagacata gatccaagca 1803721 ctgtcacata tatcgaagca catggaacag ggacggaatt gggcgatccg attgaaataa 1803781 atgggctgaa agccgcgttt aaggaactat ccaatatgag aggcgagagc cagccggatg 1803841 ttccggatca ccgttgcggc atcggctcag ttaaaagcaa tatcggtcat ttagagctag 1803901 cagccggtat ttccggtttg atcaaggtgc ttttgcaaat gaagcataaa acgttagtga 1803961 aaagcctgca ttgcgagacg cttaatcctt atcttcagct gactgacagt ccgttttaca 1804021 tcgttcagga aaaacaggaa tggaagtctg tcacagatcg tgacggaaac gagcttccgc 1804081 gccgtgccgg aatcagttcg tttgggattg gcggagtaaa cgcgcatatt gtgattgaag 1804141 aatatatgcc aaaagccaat tcagaacaca cggctacaga acagccaaac gtaattgtgc 1804201 tgtcggctaa aaataaaagc aggctgatag atcgtgcttc gcaattgctt gaggtgattc 1804261 gcaataaaaa atatactgat caggatttgc accgcatcgc ttacaccctg caggtcgggc 1804321 gcgaagaaat ggatgagcgt ctggcgtgtg ttgcggggac aatgcaggag cttgaagaga 1804381 aactgcaggc gtttgttgac ggtaaggaag aaacagacga atttttccgg ggacagtctc 1804441 atcgaaataa agagacccag actattttta cagcagatga agatatggcg ttggcacttg 1804501 atgcttggat cagaaaaaga aaatacgcca aacttgctga tttatgggtc aaaggggtct 1804561 caatccagtg gaacacatta tacggagaga ccaaaccgcg cctgatcagc ctcccttcat 1804621 atccgtttgc gaaggatcac tattgggtgc cggcaaagga acattcagaa agagacaaaa 1804681 aagaactggt taatgcgatt gaagatcgcg ccgcatgctt tttgacgaaa caatggagtt 1804741 tgagtccaat tggatcagca gtgccgggga caagaactgt tgccatcctg tgctgtcaag 1804801 agacagcaga tttagcagca gaagtgtctt cgtattttcc gaatcatctc ttaatagatg 1804861 tgagccggat agaaaatgat cagtcagaca ttgattggaa agagtttgac ggcctagtgg 1804921 atgtcatcgg atgcggttgg gatgatgagg gccggctgga ttggattgaa tgggtgcaaa 1804981 gactggttga attcgggcat aaagaggggc tcaggctgct ttgtgtgacg aaggggctcg 1805041 aatcgtttca aaacacatct gtccggatgg ctggcgcctc acgggctggg ttgtatcgaa 1805101 tgctccaatg cgagtacagc catcttatat caaggcatat ggatgctgag gaggttactg 1805161 atcatcgccg tctcgcgaag ttgatcgctg atgagtttta ttccgattct tatgatgcgg 1805221 aggtttgcta cagggatggt ttacggtatc aagcttttct aaaagctcat ccggaaacag 1805281 gtaaggccac ggaacagagc gcggtcttcc cgaaagatca tgtacttctc attacaggcg 1805341 gcacacgagg catcggacta ttatgcgccc gtcattttgc agagtgctat ggagtgaaaa 1805401 aactggtgct gaccggacga gaacagcttc ctccgcgaga ggagtgggct cgttttaaga 1805461 catcaaacac atcattggca gagaaaatcc aggcagtgcg ggagctggaa gcgaagggtg 1805521 tacaggtgga gatgctgtcg ctgacgttat ctgatgatgc tcaggttgag caaacgctgc 1805581 aacatatcaa gcgaacatta ggaccgattg gcggtgtcat tcattgtgca ggtctgacgg 1805641 atatggatac gctggcattt atccgaaaaa cttcggatga tatccagcgg gtgctggaac 1805701 ctaaggtgtc aggtcttaca acgttatatc gccatgtgtg taacgagcct ttacagtttt 1805761 ttgtcttatt ttcttctgtt tcagccatta ttccggagct ttcggcggga caagctgact 1805821 atgcgatggc caatagctat atggattatt ttgcagaagc acatcagaaa catgcgccga 1805881 tcatcagtgt tcagtggccg aactggaaag aaaccggtat gggtgaagtg acaaatcaag 1805941 cgtatcggga cagcggcttg ttgagcatta cgaattcaga aggcttacgt tttctagatc 1806001 aaattgtatc gaaaaagttc ggaccggttg ttctccctgc aatggcgaat caaacaaact 1806061 gggagccgga actgctgatg aagaggagga aaccgcatga gggcggtttg caggaagctg 1806121 ctttacagag cccgccagcc agagacattg aagaggccga tgaagtttcc aaatgtgatg 1806181 gattattatc tgaaacacag tcctggctta ttgatctgtt taccgaagag ctgagaatag 1806241 atcgtgaaga cttcgagatt gacgggttgt ttcaggatta tggcgtggat tcgatcattt 1806301 tggcacaggt gctccagcgt ataaaccgca aattagaggc agcgctcgat ccatcgattc 1806361 tatatgaata cccgacaatt caaaggttcg cagattggct gatcggttct tattccgaaa 1806421 ggctgtccgc tttattcgga ggcaggatat cggatgcatc agcacctttg gagaacaaaa 1806481 tagaggcgga ggcatctgtt cctgggaagg atcgagctct tacacctcag attcaggcgc 1806541 cagcgatttt gtcaccggac tctcatgcag aaggtattgc cgttgtcgga ctctcttgcc 1806601 gattccctgg ggcagagaca ttggagtcat attggtcgtt actatccgag gggcgttcgt 1806661 caatcggccc gattccggca gagcgttggg gctgtaagac gccatattat gccggcgtga 1806721 ttgatggcgt cagctatttt gatcctgatt tctttttgct tcacgaagaa gacgtaaggg 1806781 cgatggatcc gcaagcactg ctcgtgttgg aagagtgtct gaagctcttg tatcacgccg 1806841 gttatacacc tgaggaaata aagggcaagc ccgtcggtgt ttatatcgga ggcagaagcc 1806901 agcacaaacc tgatgaagac agccttgatc atgccaagaa tccgatcgtg acagtcggcc 1806961 aaaattattt agccgctaat ctttcacaat tttttgatgt ccgcggtcca agtgttgtag 1807021 ttgacactgc atgctcgtca gctttggtcg gcatgaatat ggccattcag gcgctgcgtg 1807081 gcggagatat tcaatccgcc atagtcggcg gtgtcagctt gctgagctca gatgcgtctc 1807141 acaggctgtt tgaccggcgc ggcattttaa gcaagcattc atccttccat gtgtttgatg 1807201 agcgtgctga cggagttgtg ttaggtgaag gcgtcggaat ggtcatgcta aaaaccgtaa 1807261 aacaggcact ggaagacgga gatatcatat atgctgtcgt caaagcggcc tcggtcaata 1807321 acgacggaag aacggcggga cctgcaacac ctaatcttga ggcacaaaag gaagtcatga 1807381 aagatgcgct tttcaaaagc ggaaaaaaac cagaggacat cagctacctt gaggcaaacg 1807441 ggtcaggttc aatcgtaacc gatctccttg agctaaaagc gatccaatca gtgtaccgtt 1807501 ctgggcactc atcgcctctt tctcttggct caatcaagcc gaacatcggg catccgctat 1807561 gtgctgaagg gatcgccagc ttcattaagg ttgtgctgat gctgaaagag cgccgctttg 1807621 tcccattttt atcaggtgaa aaagagatgg cgcatttcga tcaacagaaa gcgaacatca 1807681 cgttcagccg agccctggaa aaatggacag attcgcagcc tactgcggct attaactgct 1807741 ttgccgatgg ggggacgaat gcccatgtca tcgtagaggc gtgggaaaaa gatgaaaaac 1807801 acgccatcaa gcgcagtcca atatcgcctc ctcaattaaa gaaacgaatg ctttcgccag 1807861 gcgagccaaa gctggaagcg gagacttcaa aaatgactgc ggcaaacata tgggatactt 1807921 atgaggtgga ggtctaacgt gaaaaagata acgaaacaac tcacattatc gttaaaaaat 1807981 ccgtttattt atcaccatgt ggtttacgga caaaatgtcc tgccgggatt ggcttatatc 1808041 gatataatct accagatatt cagagaacac ggtttctcct gctcagagct tcagctgcgg 1808101 aatttatcca tctatcagcc attgacggcg gaacaggatg cagtaattgt tttgaatatc 1808161 caatgcgcgg agaaaaaaga aggacagtgg caaatcacag ccaagggaat tgaaaaacgt 1808221 gatgggaaag aagcttcaga agaaaagctc tatatgaagg ctgacatgca cgcagactcc 1808281 ccagccatat ttgaagaaac actggatctc agtcaaatca aagcatctgc acagaacgtt 1808341 gttcagcttg atgatgtata tgaacaatgc agacgtcagg aattggtgca cagcgaatat 1808401 atgaaagcaa aaggctgcat ctatgaagag gaagacggcg tccttcttga gctttctctc 1808461 ggttcggagg ccatgcttca cgcagaaggc tttatgtttc acccgactct catagacggg 1808521 agcggggtgg gtgccaatca tttgctcaca tctttgctta aaggagaaca gaggctgtat 1808581 ttgcctctgt tctatgaatc cttttccgct tctgcacttt tgcaaacgga ttgcatgaca 1808641 agaattaagc gctcctccgt ccggcgggaa aaagagctga tttatgtaac acttgaattt 1808701 tttaatgcgt cgggagaaaa agtggctgag ttgaaaaact ttacaagcaa attggtgcga 1808761 gaagcggagc tgattagcgg aaaacatcaa gatgcacagg agacacagat gacaagagcg 1808821 gacactgctg agcgtgataa acctgctgac atggtatctt ctcccgttaa ttcctatagt 1808881 gaggctgaac agttcgtaag ccaattaatc gcagagaaaa tcaataagcc ggtagaacaa 1808941 gttgaaaaac aggtcggtta ttaccaaatg ggactgaatt catcgggctt gcttgaggtg 1809001 gtagaaacga tcagtgataa gatcggtgag agcctttcgc cgactcttct gtttgagcat 1809061 accaccatag cggaactgtc agcgtttctt gccgaggaat atgctgagca ttttagtgcc 1809121 gctggttctc ttggccagaa tgaaagagca cgcgtttccg acagcataaa cgaccataag 1809181 actgttgaag gctctcgtcc tgcacctatt gaggcagcag gcgatattgc gattatcggc 1809241 ttggcgggca ggtatccgaa ggcagccaat attcatgaat tttggaacaa tctgaaagag 1809301 ggtaaggact gcgttagtga gattcctgag tcgcgctggg attggcagcg acttgaagga 1809361 atcacatctc cttcgggtaa ggacatttcc aaatggggag gatttattga tgatcccgac 1809421 tgcttcgatc cccaattttt cagaatcacg ccaagagaag cggagacaat ggaccctcaa 1809481 gagcggctgt ttttagaaac atgctgggaa acgattgaag atgcgggcta tacgccaaag 1809541 acgttggcca agcctaaagg acgaaataaa aggcagcatg taggagtttt tgcaggcgtc 1809601 atgcacaagg attatacatt agtcggagct gaagaagcat cagcagaaaa tgtgtttcct 1809661 ctttcgctca actatgcgca aatcgccaac cgtgtttctt acttttgtaa tttccacggt 1809721 ccgagtatgg ctgtcgatac ggtatgttca tcctctttga ccgcagtgca cttggcgttg 1809781 gaaagcatac gtcacggtga gtgcgatgtt gcgttagcag gcggagtgaa cctgtctttg 1809841 cacccgaata aatatatgac atacggggtc tgggatatgt tttccactga cggacactgc 1809901 cgtacgtttg gaaaggatgg agacggttat gtgcctgcag agggtatagg cgcggtttta 1809961 ttaaagcctt tgcgccaggc agaggaagac ggagatcgca tttatgcagt tattaaagga 1810021 agtgctgtga atcatgtggg cactgtaagc ggcatttcag tgccgagccc tgtttcccaa 1810081 gctgatctga ttgagacatg cttggagaaa acgggaatcg atccgcggac gatcagttat 1810141 gtggaagccc atggaaccgg cacgtcctta ggagatccga tcgaaataca gggattagtg 1810201 aaagcgttcc gccaatatac gcaggatcgg cagttctgtt caatcggttc tgtaaagtca 1810261 aacattgggc acgccgaatc cgccgcgggg atcagcggtt taagcaaggt tgctcttcag 1810321 cttcaccatc aaaaacttgt gccttctttg cattcggaag aactgaatcc gtacgttgat 1810381 tttgaaaagt ctccatttta tgtacagcat gaaacagaaa cgtggaagca gcctgttatc 1810441 aaggagaatg gggaagacgt cccttatccg cgacgggcgg ggatcagttc ttttggcgca 1810501 acaggttcaa acgcacatat tatccttgag gaacatattc ctcaagcagc ggagcaggac 1810561 gtttctttgt cctcagattc tgacatatcc gcagttattc cgctttctgc ccgtaatcaa 1810621 gaacgtctcc gtgtatatgc aaaacgtctc ttggattttc ttcatgatgg gattcagatt 1810681 agagatttgg cgtatacatt gcaggtaggc cgtgaaccga tggaagaacg ggtttctttc 1810741 ttagcatccg gaattcaaga attgagcgac caattgaagg cttttataga aggacgaaaa 1810801 gccattcagc attgctggaa gggccgcgtg tcaagaggaa gcgaaccatc gcgtcccgcc 1810861 gaatcggtac ataaattgct ggagcaaaga aaactcgatc agattgcgga gcagtgggcg 1810921 aacggatctg gtgttgactg gaagctgctt tacgagggaa gcaaaccaaa gcggatcagc 1810981 ctgccgactt acccatttga gagggtgcgt tattgggtgc cgaaagcgga gaaaaagact 1811041 gatcgttcaa aacaggagcg gcacatcctg catcctcttc tgcatcaaaa tgtgtccgac 1811101 atatcgggtg tccgcttccg ttcagcgttt acaggacgtg aatttttctt gaaggatcat 1811161 gtcataaagg gcgaacacgt tttacctggc gcagctttat tggagatggt tcgggcagct 1811221 gtggaaaggg cagctgcgga tcagttcccg acaggattcc ggctccggaa tatcgtctgg 1811281 gtccggccgt tcgccgtcac ggaacagcag aaagatatag atgtacgtct atatcctgag 1811341 gaaaatggtg agattacatt tgaaatctgc cgggaccctg aaagcgcaga ggagtcgccg 1811401 attgtatatg ggcaagggag tgcagtgctt tgtgaggctg gtgaaaatcc ggttatcaac 1811461 attgaagaat tgaaggcaag ctataatggc cggacgctgt caccttttga ttgctacgag 1811521 gcttatacag aaatgggtat tcattatggt gacagccaca gagcgatcga cagcctatat 1811581 gccggcgaaa acggagttct agtgaaattg acgatgcctc ctgtaatctc tgatacagaa 1811641 gaccattata ttctgcatcc gagcatgata gattcggcat ttcaagcatc tatcggtttg 1811701 aggctgggag gagctacgag tttagaagac agaaaggcaa tgctgccttt tgccatacag 1811761 gatgtccgaa tcttcaaagg ctgcgaggca tctatgtggg cgcggatcac atatagcgag 1811821 ggcagtacag ctggggatcg tatgcagaag cttgatatcg atttatgcaa tgaagagggc 1811881 caggtttgcg tgcgattgac gagctattct gcaagagtgt tagaaacaga tcaagaaggt 1811941 ccttctgaag cgaatgacac gctattgttc gaacatattt gggaagaacg tgctgcagag 1812001 aggcaagagc tcatagagta cgacacgtat aaagtcgttg tctgtgatgt tggagaacaa 1812061 atggaaagcc tccaaaatca tcttgactgt acagttctgc agcatgatac agagacaatt 1812121 gatgaacggt ttgaaggtta tgccatacag ttatttgaag aaatcaaaca gctaatgcac 1812181 tcaaaaacag gaggacatac attcattcaa gtggcggtgc ctgcgttgga cgagcctcag 1812241 ctattaagcg gcttaactgg attgctcaaa acggctgaac tggaaaatcc aaaactgaca 1812301 ggacagttga tcgaaataga aaccgggatg tcagctggtg agctattcga aatattggag 1812361 gaaaacagac gctatccgcg tgacacgcat atccgccact ggcaagggaa gcgatttgta 1812421 agcaagtgga aagaagtgtc tggtgagcac ctaagtgctg acatgccatg gaaggataaa 1812481 ggcgtgtatc tgatcacagg cggtgcgggc ggtctgggat tcatctttgc aactgaaatc 1812541 gcaaaccaaa cgaatgatgc ggttgtgatc ctgacaggac gctctccgct tgatgaaagg 1812601 aagaagaaga agcttaaagc cttacagaaa cttggcatcc aagcgattta cagacaagct 1812661 gatctggctg acaaacaaac ggttgatgcc ttattaaaag aaacccaaaa cgtttacgga 1812721 gacttagatg gcatcattca tagcgccggt ttaataaaag ataatttcat tatgaagaaa 1812781 aagaaagaag aggttcaaac cgttcttgct ccaaaggtag caggactgat tcaccttgac 1812841 gaagcaacga aagatattcc gctcgatttc tttatccttt tttcctcagg tgccggagca 1812901 gtaggaagcg cgggacaggc tgattacgca atggccaatg catttatgaa tgcattcagc 1812961 gaatatcgaa atggccaagc agagctgcat aagcgttacg gaaaaactct ttcagtgtgc 1813021 tggccgctgt ggaaagacgg gggcatgcaa attgatgcgg aaactgcaag gatgctgaaa 1813081 agagaaacag gcatggtggc catggaaaca gatcgtggga ttcaggcgct atatcatggc 1813141 tggacgtcag gaaagccgca agtgttagtt gcttccggtg ttactgatcg gattcgtgca 1813201 tttttacatg aaacgggaca tggcaaaggc caatctcaca atatcaaaaa aagcagtctc 1813261 aatcaggagg cagaaaaagc agacatgatc ggggaaattg atgaagagat actaagagaa 1813321 aaagcggaga actattttaa acaggtgctt tcttcggtga ttaagctgcc agctggccag 1813381 attgatgctg aagctcctct cgaggattac gggatcgatt ctatcatgat catgcatgta 1813441 acgggtcaat tagaaaaagt attcggatct ttgtccaaga cgctgttctt tgaataccag 1813501 gatattcggt cattaacccg gtattttatt gattcccgca gagaaaaact gctggacatc 1813561 ttgggatttg aaacgggaaa accttctgtt gaaagaaaat cagaacctga aaaacaagaa 1813621 atcccagtta tcccaagaaa gtctggattt cttcctttgc aagataaaga gcagaagcag 1813681 gtaagagaga aggaaacgga agaaattgcg atcatcggta tctcaggtcg ctatccgcag 1813741 gcagacaaca ttgatgaatt atgggaaaaa ctgagggacg ggcgagactg tattacggaa 1813801 attcctgcag accgctggga tcacagtctt tattatgacg aagataaaga caagcctgga 1813861 aaaacctaca gcaagtgggg cggcttcatg aaggatgtag acaagtttga cccgcagttt 1813921 ttccatattt cgccgcgtga ggcaaaatta atggacccgc aagagcgttt atttttgcag 1813981 tgcgtgtatg aaacgatgga agacgcaggc tatacaagag agcacctcgg ccgtaagcgt 1814041 gatgctgagc ttggcggaag cgtcggtgtt tacgtcggtg tcatgtacga agaatatcag 1814101 ctgtacgggg cacaagagca ggtgcgggga aggtctctgg ctttaacggg aaatccatca 1814161 tccatcgcga accgggtatc ttattatttt gattttcacg gaccgagtat tgctttagac 1814221 accatgtgtt cttcttcttt aacggctatc cacttggcct gccaaagcct gcagcgcgga 1814281 gaatgtgagg cggcattcgc gggcggcgtg aatgtgtcaa tccatccaaa taaatatttg 1814341 atgctcgggc agaacaaatt tatgtccagc aaaggccgat gtgaaagctt cggacagggc 1814401 ggagacggct atgtgccggg ggaaggcgtt ggagcagtgc ttttgaagcc attgtctaaa 1814461 gcagttgaag atggtgatca catttatgga atcattaagg ggacagccat caaccacggg 1814521 ggaaaaacaa acgggtactc agtgcccaat ccgaatgccc aagcagatgt catcaaaaag 1814581 gcgtttgtgg aagcgaaggt tgatccgcgg acagtcagtt acatcgaagc ccacggcacg 1814641 ggaacctctc tcggtgatcc tattgaaatc acagggctgt ccaaagtgtt tacgcaagaa 1814701 accgatgaca aacaattttg tgcaataggg tcagccaaat caaatatcgg gcactgtgag 1814761 agtgcggcag gtattgcagg agtaacgaag gtattgctcc aaatgaaata caggcagctt 1814821 gcgccttccc tgcattcaaa cgtgctgaac ccgaatattg atttccttaa ctcgccgttt 1814881 aaagtacagc aagagctaga agagtggaag aggccgatca tcagtgtcaa tggcaaagac 1814941 atcgaattac cgagaatcgc aggagtctct tcatttggtg ccgggggtgt gaacgcccat 1815001 attttaatag aagagtatgc tccggaacct gtggaggaac gtttaccagc gaggaaacag 1815061 ccggctgtca ttgtgctctc agcaaaaaat gaggaaagac ttcagaaacg cgcggagcga 1815121 ttgctgcatg ccattcgtga acaaacatat gttgaagcag atttacaccg aattgcctat 1815181 acgctgcaag tcggccggga agcgatgaaa gaacggctgg cgttcgttgc ggaaacgatg 1815241 caagagcttg aagaaaagct gtatgaatgt atctccggaa cagaaaatcg tgaatatgtc 1815301 tatcgcggac aagtaaagag caacaaagaa gccattgctg cttttgctgc tgatgaggat 1815361 atgtcaaaaa caattgaggc atggctgcaa aaaggaaaat atgcgaaggt tttagacctg 1815421 tgggtaagag gtttgcgaat cgactggagc acgctatatc aggatcaaaa accgcggcgc 1815481 atcagtttac ctgcctatcc tttcgcaaga gatcgctatt ggatagacgt aaatgcaaag 1815541 gctgaggaaa aaagaacgga ggagccattc gctccagtac agcccgttat tccgaagccg 1815601 tctgtagaca gagaagccag tggcaagcct gccaatatta cgttacagcc tttaatgacc 1815661 aatcaggatc gtttagagcg tgttccatca gatacagaaa cagagacgat cacggcggaa 1815721 gccttgtgcg atgaactgac agcgggctta gcggaagtgc tgtacatgga ccaaaacgag 1815781 attgatccag acgaagcatt catagatatc ggtatggact cgattaccgg gctcgaatgg 1815841 ataaaagcaa taaataaaca gtatggcaca tcactaaatg tcacaaaggt atatgattat 1815901 ccgacaacac gtgatttcgc tgtttactta gcacacgagt taagcacaca agctggggag 1815961 aaaaaacaaa cggagacgta cacgccgatc agacaaaaaa cagtggtacc tgctgctaaa 1816021 ccggctaata tatctctgca gccgttagaa catcatcagc cagtgcaaga ggaagctgaa 1816081 gaaacgattc aatatgcagc ggcagaaata tctgcatcaa gacaatatac tgtagcaatt 1816141 gaaacgctgc atgaaaactt gagggaaagc atagcagacg tgttatacat ggagccatac 1816201 gaggtggata ttgacgaagc gttcatagat atcggaatgg actcgattac cggactcgaa 1816261 tggataaaag cggtgaacaa gcaatacgga acgtctttta cggtaaccag agtatatgat 1816321 tatccaacga tacgtgattt tgccgaaatg ctaaagtccg agcttggaac tcatcttgat 1816381 agaaagatag agcatactga ctctttcgaa gcagcccagc aaaagccagc agcatcatct 1816441 catccaaagc cggcagaacg gccactacag cctgttcaac atccaataaa gaaagaacat 1816501 gagaagaaaa cggttcctgt tcttcaagac cgcccggagg atgcgatagc gattgtcggg 1816561 atgtcgggaa gatacccggg cgctcgtaat gtaagagagt actgggataa cctggttcat 1816621 gcgagaaatg ccattcggga cattccaaca tcacggtggg atgttgacaa atactatgat 1816681 cctgtcctca acaaaaaagg gaaagtctat tgcaaatcaa tggggatgct tgatgatatt 1816741 gaacattttg atccgttgtt ttttaatatt ccgccgtcag aagctgaact gatggacccg 1816801 cagcatcgaa tctttttgca ggaaggctat aaagcctttg aggacgctgg gtacaacgcc 1816861 cgaactttaa atgagaaaaa atgcggtgta tatctcggca ttatgagcaa tgaatacggg 1816921 gtcatgctga atcggcagtc aagagcaaat gccaccggaa acagctttgc gatcgcagcg 1816981 gcgcgtattc cgtattttct aaatttaaaa gggccagcga ttcctattga taccgcatgt 1817041 tcatcttcat tggtcggcac tcatttagcg cgccaggcac ttataaacaa agaaattgat 1817101 atggcgctgg tcggcggggt cagcttatac ctgacgccgg aatcttacat gagtatgtgt 1817161 gaggccggca tgctttcacc tgatggacaa tgtaaagcat ttgacaatgg cgcgaatggt 1817221 tttgtgcccg gcgagggtgc gggtgcgctg gtattgaaaa ggctgaaaga tgcggaagcg 1817281 gaccgtgacc atatttatgg catcatcatt ggctcgggta ttaatcagga cgggaaaaca 1817341 aacggaatca cggcaccgag tgcgaaaagc caaatggatc tggaaagaga catatatgaa 1817401 acatacggca tacatcctga gagtatcagt tatgtcgaga tgcacggcac aggaacaaaa 1817461 caaggcgatc caattgaatt agaagctctg tccaccgtat ttcaagaaaa aacagacaaa 1817521 aagcagtttt gcgcaatcgg ttccgtcaaa agcaatattg gccatacatc cgcggcggca 1817581 ggagtagccg gggttcaaaa agtgttattg tgcatgaatc ataaaacact tgtgccgaca 1817641 ttgaacttca cgacaccgaa tgagcatttt gaatttgagc attctccttt atacgtaaat 1817701 acggagctta agccttggga aacggctgat ggaaaaccgc ggagagcatg tgtgagctcc 1817761 ttcggatata gcggaacgaa tgcccatatt gtgatagagg aatatcagcc tgaaaagagg 1817821 aacgatcgat taacaaagca gcaccgctca gcattatttg tactctcagc gaaaaaagag 1817881 aagcaattga aggcctatgc ggaagcaatg aaagatttcg taacttccaa tgaagatatc 1817941 gatctggagg atatggcata cacacttcag acgggccggg aagcaatgga ttatcgcatg 1818001 gcgtttttgg cggattcgag agaaatgctg atcaaagctt tagatgatta tttggctgaa 1818061 atgccgaacg gcagcatatt tgctgctcac gtgaaaacga agaagagcga aatcaagctg 1818121 tttgaaacgg atcatgatgc caaagcattg ctgcaaacat ggatagagaa aaaaaggctg 1818181 gagaaagtag cagagctatg ggtgaaaggg ctgcagatag attggaacaa gctttatggg 1818241 gaatacacgc ctcgccgaat cagcctgcct gcttatccgt tcgcggaaga gtattactgg 1818301 ctgccaactc aagaaggcga acccgaaacc attgctacag caatgcctca attcgaactg 1818361 atgccaaagc gctgctttct gcgtaaacag tggcagcctt gtccgattga accggcagaa 1818421 atgacgaatc aaaccgtcgc cattttggca aatgaggaga caatggcatt agcggaagag 1818481 ctttcggcgt atttctcgac ataccgtata tttgacagcc aagagctgga tcgggtatct 1818541 gctgctgact atgaacacgt tgctggagca atcgatctga tcgggtgcgg aacgagccat 1818601 gagcattcta tgggctggat aaactggctc caaaagctga tcgagcaagg acgtgcaagc 1818661 aagcatcatt tgacggtctt gggtgtaaca aaggggctgg aggcctacgc aaatgagggt 1818721 gttcttttgt ctggtgcttc acgggccggt ttataccgca tgcttcaaag tgagtacagc 1818781 catcttactt caagacatgc agatatggaa tgcgaagcct ctcatgagga gctggccaga 1818841 ctgattgcag ttgaatatta tgccaagagc acagaatcag aagtctgtta tcgaaacgga 1818901 cagcgatatc gcgcatattt gacagagcag ccagcagaag ccgctctaag tcataagcaa 1818961 gtatcgtttt caacagacaa agtcctgctt attacaggcg ggacaagagg tctcggcttg 1819021 ctgtgtgcgc ggcattttgt gaaaacatac ggcgttaagc ggctggtcct tatcggccgt 1819081 gaagagcttc cgccgcgtga ccagtggaat tcggtaaaaa tttcctcgct tgccgagaaa 1819141 ataaaagccg ttcaagagct agaagacatg ggtgcgcaag ttcaggtgct gtctctggat 1819201 ctcacagaca gggttgctgt cgaacagagc ctgaagacaa tacacgaaac aatgggggcg 1819261 attggcggag tcatccattg tgccgggatg gtgaacaaac aaaacccggc ttttatcaga 1819321 aaatcactag aagagatcgg acaggtgctt gaaccgaaag tcgaaggtct gcaaacgttg 1819381 tttgacctgc ttcaagatga accattggcg tttttcacct tgttttcatc agtatcagcg 1819441 gccatccctg cactagcagc aggacaagct gattacgcga tggcaaatgc ttttatggat 1819501 tattttgcgg aggctcatca agataaatgt cccattgtaa gcattcagtg gcctaactgg 1819561 aaggagaccg gtttaggcga ggttcgaagc aaagctttag aacaaactgg attgatcagt 1819621 ttgacaaacg acgagggatt acagctgctt gaccagattc tatcagacag acagtatgct 1819681 gtcgtgctgc cggcagtacc agatacaaac gtttggaagc cggataagct gatgcagccg 1819741 tcattgcctg tcgaagctct ctcgcatcct gagacgaaag agcaaaccag cactcgcaac 1819801 ctgttccctg aaacagtcga ctggctcgta actctttttt cagatgaact gaaaatagct 1819861 gcagaagact ttgaaacgga tgaacctttc caagaatacg gaatcgactc gattatattg 1819921 gcccagctgg tacagcagat gaaccaacaa ttaaatggag atattgatcc gtcaatcttg 1819981 tttgaatacc cgacaataga atcctttgca cactggctca tttcgaaata tgacatatca 1820041 gctgttttac agccatctgt tcctgagaaa cagacacctc tcaagccgca atcagcaatg 1820101 aaacagaagc tggtgccaga acagcggccg caacagataa gccatgaaaa aacggcactt 1820161 cttgctgagg acatcgctat catcggtctt agttgcaggt tcccgggagc agaaacccta 1820221 gaggaatact gggatttaat acgtgatgga cggtctgcga ttgcgcctgt tccgcctgaa 1820281 cgattcggga actccagctc gaattacgcg ggcctcattg atgaaatgaa ccgatttgat 1820341 catgatttct tcatgatgtc cgaaagcgat gtcagagcga tggaccctca agctttggct 1820401 gtattggagg aaagcttgaa gctatggtat cacgcgggtt atacagagaa agaagtgaaa 1820461 ggcatgaggg ctggtgttta tataggaggc cgcagccagc acaagcctga tccggccagt 1820521 ctttcaaaag caaaaaatcc gatagtcgct ggtggacaaa actatttagc ggctaacatc 1820581 tcacaatttt ttgacttgaa gggaccgagt attgtcctgg ataccgcttg ttcctctgca 1820641 ctggtggggc tgaatatggc cattcaggct ctgcgaagcg gagatattga ggcagcggtt 1820701 gtaggcggcg tcagtttgct tgatgctgat gcgcatcgaa tgtttcatga gcgcggactt 1820761 ttatgtgaca aaccgtcatt ccatattttt gataagcggg cagacggtgt cattttagga 1820821 gaaggcgtgg gcatggttct cgtcaaaacc gtcaaccaag cggttgaaga cggagattcc 1820881 atatatgcag tcattaaagc cgctgcgatt aataatgacg gaagaacggc aggcccatca 1820941 tctccgaatc tcgaggcaca aaaggacgtc atgctgtcag cgcttgaaaa aagcggcaaa 1821001 aagactgaag agatcagcta tctcgaagcg aacggatcgg ggtcggcagt aacagattta 1821061 cttgaattaa aggcaatcca gtccatttac cgttctgaat caaaggctcc gttagggctg 1821121 ggatcggtga aacctaacat cggccatcca ttatgtgcag agggaattgc gagcctgatt 1821181 aaagtagctt taatgctgaa gcatagacaa ttggttccgt tcctgtcagg taatgaaaat 1821241 atgccgtatt ttgatataga aaaaacagat ttgtatttca gcagatcgca agccgagtgg 1821301 aaggagacaa cgccggctgc ggcaattaat tgttttgcag atggcggaac gaacgcccat 1821361 ctcattatag aaggttggag agactcggct gagcgtccaa ttagaagaaa acctctgcct 1821421 ttgccggaat taaataggca gcccgtttta atcaaaccat cagctcaaaa cgtgcagaaa 1821481 aaagtgcatt cagacacagg ggcttctaaa gatatgtttt ggaaaacttt caaataagag 1821541 aggagtggga aaatgataac tgaacaactg cacatttcat taaataatcc aatcatgtcc 1821601 aaccacaagg tatatggaca agcgttatta cccggccttg cttatataga tttaatctac 1821661 caagtattcc aggaacatgg ttatgcatac caagagcttg aattaaaaaa cctaaccatt 1821721 ttttaccctt tgatcgcaga tgagtcatat gacattgccc tgaccattca cgtgtctgaa 1821781 agaaaggaag ggacatggtc catcatcatc gacggacaaa aacagcatgg agaatcacta 1821841 tctgacaaga gacaatatgt gactgctgac atgcatcgta aagagcaaac cgcttttgcc 1821901 gaatcaatag accttaatca gtggaaaagt acagctgaca ggattctgaa tttagatgaa 1821961 atctatgaac aatgccgatc tcaagagtta gtgcataccg gcatgatgaa ggcggaagga 1822021 cagatttatg aagccaaaga gggggctgta attgatttag cagtcggaca ggaagcattg 1822081 cgtcattctg atgcttttct gtttcatccg acgcttattg acggcagcgg cataggttca 1822141 agctgcctga tctcagatca aacgatgtac ctgccattgt attatgaatc gttttctgct 1822201 tcagaacgat tgcaaaaagg atgtacagca cggatcctct cctcatctgt gcgccaaaag 1822261 aaagaactca cttatatgac gattgaatat tttaattcag caggacaaaa agtggccgag 1822321 ctgaaacaat ttgcaggcaa gtctgtacgg aatatgtcag cctttcattc tgcaaaagaa 1822381 attcaagaag aaagagctgc tgtctctcag aacatcagtc gggactatcc cgcatttgaa 1822441 atgtatttgc gtcagctgct tgctaagcag cttgaaaggc cggcagaaca aatggatatc 1822501 cacgctgggt actatgagct tggtctggat tcttcgtcat tgcttaccgt ggttcaggaa 1822561 attggagata aggttggggc ggatcttgct ccgacactgc tgtttgaatt tacaacaatt 1822621 gcagaactag ctgctcatct tgctgatcac tattcaattg gagaggcgga cgatgctgtc 1822681 cgccaatctc cttcaccaat tgatggtgtt acctcttcac cagagatcgg ggaggacata 1822741 gccattatcg gaatggcggg acgctatcct aaggcgaaaa atatacagga attttgggaa 1822801 cagcttaaag cgggtaccga ctgcatcaca gagattccaa actcacgctg ggaatggaaa 1822861 gaaagcgatg gactggattc acctgcaggc aagccgctct cgaaatgggg cggctttatc 1822921 gaggaggctg attgctttga tcctcaattt ttcagaatct ctccgcgtga agcggaaatg 1822981 atggaccctc aggaacgctt atttttagag acgtgctggg aagctattga agatgcgggt 1823041 tatacaccag agacaattgc ttcaccgcag ggagaaaata aaagacagca tgtcggtgtg 1823101 tttgccggcg ttatgcataa ggactattct cttataggag ctgaagctct atcagaacac 1823161 aatccatttc ctttatcgct gaattatgcg caaatcgcca acagggtctc ttactattgt 1823221 aatttccacg gcccaagcat ggcggtggac acggtctgct cttcctcatt aactgcggtt 1823281 catctggcaa tagagagcat ccggaatgga gaatgcgagg ccgcgcttgc cggaggcgtc 1823341 aatttgtcac tgcatccggc taaatatatc agctatggca gtgtagggat gcactcaagt 1823401 gacggctatt gccatacttt cggcaaaggc ggggatggct acgtatctgg agaaggtgtc 1823461 ggcacagtat tgctaaaacc gctgcgaaaa gctgaacagg acggtgaccg aatctatgct 1823521 gtcatcaaag gcagtgcgat aaatcatgta ggaaaagtaa gcggaattac agtaccgagc 1823581 ccggtagctc aagctgatgt aatcgaagca tgtctagaaa aaacaggaat tgatccgcgc 1823641 accatcagct atgttgaagc ccatggcact ggcacctcat tgggagatcc gattgaagta 1823701 caggggttag taaaagcttt cagccgcaat acgcaggaca agcaattctg ttcaatcggt 1823761 tctgtgaaat caaatattgg ccatgctgaa gctgcagccg gcattagcgg cttaacgaag 1823821 actgtcctgc agctgcatca taaaaccttg gtgccgtcat tacattcaga agagctgaat 1823881 ccttatttga agcttgatca aaccccattt tttgtccagc atgaaacaaa ggaatgggag 1823941 cagccatctt ttacagaaaa cggggtggac gtcacatatc cccgccgtgc cggtttaagt 1824001 tcgtttggcg cttcaggatc aaatgcgcat cttattttgg aagaatatat tccggcagag 1824061 agccattcag agacgatttt aacgaaaaat gaagaaatag tgataccttt gtctgcgaga 1824121 aacaaagatc gtctgcaggc ttacgctctt aaacttcttg attttcttag cgaggacgtc 1824181 aatcttttag cgttagctta taccatgcag gcaggacggg ttgaaatgga ggagcgtgcg 1824241 gccttcattg taaaagacat aaaagattta acggctaaac ttcgggcgtt tgccaatggc 1824301 gaagaagaga tcgagggctg ctggaccgga cgagccaagg agaatcagga ggcggctggg 1824361 ctagcatcgg taaatgcgct gaataacaat ttgataagag acagtgaaat gatggaaatg 1824421 gcgaaagcat gggttcaagg aaagcgggtc acctgggacg acctatacgg cgatcgcaag 1824481 ccgcttaaga tcagtgttcc gacctatccg tttgcaaggg agcgctactg gatctcggtt 1824541 cctgaaatga aaaccagcac tgtgaatcat atcttacatc cgctggtgca ccgcaataca 1824601 tcagacttta ctgagcagcg ctttagctct gtatttacag gcacggaatt tttcctgtca 1824661 gatcatgttg tacagggaca gaaaattttg ccgggcgttg cctatttaga aatggcaagg 1824721 gaagcagcgg aaaaagctgc aggcgatctg gacggcgaac aaagagtggt gtcgcttaaa 1824781 gacattgtgt gggtgcgtcc tatcacgata gaaagtgaac caaaagaaat acatattggc 1824841 ctttttcctg aggataacgg ggacatttcc tttgatattt atagcagctc tgaacataaa 1824901 gaagaagccc tgacgataca ctgccaaggt cgcgctgtca tttcagatga agcggagact 1824961 tccattttaa acctttcatc aatacagaca gaatgcagcc tggacacagt gacgtcagaa 1825021 caatgctatg cagcgtttcg aaagattggg cttgactatg gcgagggcta tcaagggatt 1825081 gaaaaagtct atgtcggcaa agatcaattg cttgcaaaaa tctcgttacc cgcttttcta 1825141 aaaaacgaca agcagcattt tgcgctccac ccgagtttga tggattccgc gttccatgcc 1825201 acagtcggtt ttatcgttag ctcagtcaat gccgctggac aagctcagac gctgtctctt 1825261 ccatttgcgt tacaggaggt tgatattttc agcccatgtc cagagaagat atggtcttat 1825321 attcgataca gttcagacag taaagcggag aacaaagtca gaaagtatga cattgattta 1825381 tgtgatgaga acggacgtgt ttgtgtgcga atgaagggtg cctcgatgcg ggcacttgat 1825441 ggagagcagc attcaaagcc gcaactatta actgattctc agctgaccgg gcatacggtg 1825501 atgatccccg tctgggaacc agtctctcta gaagcggagg ataatgcttc gtttgctggt 1825561 aaaagagctg ttttatgcgg agctgctgaa gctgatcgga ctttcataaa gcatcattat 1825621 ccgcaaattt cctttgtcga tatccgccct gcagatgaca ttgaggcaat agcggacaaa 1825681 ctgcaagcgt acggaagcat tgaccatgta ttgtggattg ccccgtcaca ccggggaagt 1825741 ataggtagtg atggacaaga agaagctgtt cttcacttat ttaagcttgt gaaagcatgc 1825801 ctgcaattag gctatggcga gaaacaactt gaatggtctc ttgtgaccgt ccaagcgcag 1825861 ccggttacgc aacatgaggc agtacaaccc gctcatgcaa gcattcatgg gcttgccggc 1825921 acaatggcaa aggaatatcc acactggaaa atccgtcttc tcgatcttga aaaaggctgc 1825981 acatggccgg taaatcacat gtttgcgctc ccagctgacc gccttggcca tgcttgggcc 1826041 tatcgtaatc agcaatggca tcagcagcaa ttgatcccat atcggtcctc actgtcaggc 1826101 gacacgctat atcggaaagg cggagtctat gtggtcatcg gaggagccgg gtatatcgga 1826161 gaggcgtgga gtgagtacat gatccgccgc taccaggcgc aaatcgtttg gattgggcga 1826221 agtcaactta atgctgccat ccagtcaaaa atagaccgac tttcggcgct tggccctgag 1826281 cctttctaca ttgcagccga tgcagccgat aagcattcac tgcagcaggc ttatgaacaa 1826341 gtgaaaaaac gtcatcctca tattcacggg attgttcact ctgcgatggt tttatttgag 1826401 caaagcctgg aaaaaatgaa gccggaagaa ttcaccgctg gactggcggc gaagatcgat 1826461 gtcagtattc ggatggccca agtgttccgc caggagaatg tagattttgt tttattcttc 1826521 tcttcgcttg tagcccatat caaaaatgtg aagcaaagcc attatgcctc tggctgtaca 1826581 tttgcagatg cttttgctca ccagctttct cagagctggg catgccctgt aaaagtcatg 1826641 aactggggat attgggggaa tagtgaagcg gctgaggatg aacattatgt acagctcatg 1826701 aatcaaatcg gcttaggttt aattgagccc gcggaggcta tgaaggcgct ggaagcactg 1826761 ctttctgggc cagtcagcca aacagctttc attcatacga caaagcctgt agcagtcgaa 1826821 ggcgtgaatc agaatgaatt catcactctt tatccagagc aaccttcagc agatgcagag 1826881 agcctgatgg agcgtctgcc gactacggga cgatttcaaa gagtgacaca tgaagagctt 1826941 gatgatcttc tttacaggct gttgttagga cagctgcaaa cagccgagct gtttgatggt 1827001 tatacattat cggttgaacg tcttcaacaa tataagactc gtgaatttta tggaaaatgg 1827061 attcggcaaa gcagcgaatt tctcttgcag catggctatc ttaagaaagt tggagattca 1827121 ttggtgagga aggaccaagc agaggatatc gagctgcttt ggctagaatg gaacgcgaaa 1827181 aaagaaaagt ggcttaaaga cagcgagaca aaggcgatgg ttgtattagc agaggccatg 1827241 ctgcaagcat taccggatat tttgacaggg aaagtccctg caacagatat catgttcccg 1827301 cattcctcga tggaactggt ggaaggcatt tataagcata accaagtggc agactatttt 1827361 aataaagtgc ttgccgatac attattagct tatctggatg aacgtctgaa gcacgaccct 1827421 gaggcatcga ttcgcattat ggaaataggc gcaggcacag gcggcacgag tgccggaatc 1827481 tttgaaaaac tgaaaccata tcaaaagcac atcaatgaat attgctatac agatctgtct 1827541 aaagcatttt tgctgcatgc agaaaaggaa tatggggcgg aaaatccgta cctgacatat 1827601 cagctttttg atgtggaaaa accgattgat cagcaggaat ttgaagcggg aggctatgat 1827661 gtcgtcattg ccgctaatgt ccttcacgca acaaaaaata tccgtcaaac actgcggcat 1827721 acaaaagcgg taatgaaaaa caacggaatg ctgctgctga atgaaatggc gggaaacagc 1827781 ctgttccctc acatcacctt tggtcttttg gaaggctggt ggctgtatga agatcctgca 1827841 gtgcggattc ccggctgtcc aggcttacat cctgacagct ggaaagcggc acttgaaagc 1827901 gaaggctttg aatctgtctt tttcccggcc gaggcggcac atgatctgag tcaccaaatc 1827961 gtcgcagcct caagcaacgg gctggttcga cgtatgatga aaaatgtgat cttgccggag 1828021 aaggttgttt cacaagcgtc taatcaggag ccagcctaca ttcataccat agattcagag 1828081 gaagctggac aatcgaaaca tgctctccta agagaaaaaa gcacagaata tatgaaaaaa 1828141 ctaatcgggg aaacgttgaa aattcctgca ggaaagattg agtcatctga acctcttgaa 1828201 aagtacggta ttgattctat cgttgttgtc cagctgacga atacattgcg taaagaattt 1828261 gaccatgtaa gcagcacttt atttttcgag taccagacca ttgacgcatt agtggagcat 1828321 ttcatcaaaa caaaaacaga agctctgatg aaattaacag gtcttgaccg tcaagttcaa 1828381 caacatacac cggccgaaag cagaacccaa tcttcacaga aacctgatca ggccgctaaa 1828441 agaacacggc gctttcgcaa gcttggcttc agcggggaga aagaaacacc gacaaacact 1828501 cttgcaagcc gtgacgttgc cgttatcggc atttctggac gctatcctca ggcggaaaca 1828561 gcagaagact tttggaacaa cctaaaagaa ggaagaaatt gtattgagga aattccgaaa 1828621 gatcgctggg attggaaagc ttattacgat aaagaaaaag gaaaagaagg atcaatttat 1828681 acgaaatggg gcggatttat caaggatatg gacaagtttg acccattatt ctttcagatt 1828741 tctccgcttg aggcagaaag aatggaccct caggagcgat tatttctgca aaccgcttat 1828801 gcaagtattg aagacgcggg atacacgcct gactcgctct gttcaagcag aaaaatcggc 1828861 gtctttgccg gagtcatgaa caaaaattat ccgactggct acggctattg gtctatcgcc 1828921 aacagaatat cctatttact gaatttccaa ggcccgagtc ttgcagtcga tacagcctgc 1828981 tcatcctccc tgacagcgat tcatttagcg ctggaaagca tctatagcgg atcgagtgat 1829041 tgtgccattg ccggcggtgt caatttagtt gtcgacccgg ttcactatca gaatttatct 1829101 gtcatgaata tgctctctgc tagtgataca tgtaaatcat tcggcgatga tgcagatgga 1829161 tttgtcgacg gtgaaggcgt aggcgccatt gtgttaaagc cgctgcagca agcaatagcg 1829221 gacggtgacc atatttacgg tgtgataaag gcaagtgcca ttaatagcgg aggaaaaaca 1829281 aatggataca cggttccaaa tcctcatgca caggcacagg tgattaaaga agcaattgag 1829341 cgcgccgaca ttcctgcccg aaccatcagt tatttagagg cgcatggaac aggcactgca 1829401 ttaggagatc cgattgagat agcggggtta acaaaagcat tcgagaaaga tacgcaggag 1829461 aaacagtttt gtgcgatcgg ctccagcaaa tcaaatatcg gccattgtga aagtgcagcc 1829521 ggaattgcag ggctgacaaa aatacttttt cagtttaaat atggccaaat tgcgccatca 1829581 ttgcatgctc agcggttgaa tccgaacatc gagttcagcc atacgccatt tgtcgttcag 1829641 cagcaacttg gtgaatggaa acgcccggtg attggcgggc aagaggtgcc taggcgcgct 1829701 ggcttgagca gttttggcgc cggagggtcc aatgcccata tcatcctgga agaatatatt 1829761 ccaagaacgg gggcgcaaac gccgaaagac catcctccag cgctgattgt gctgtcggcc 1829821 aaaaacatgg aacgtttgca agaaaaagcg gaacagctgc ttacagccat caaacaaaaa 1829881 aggtactgcg aaacagacct gatcaggatc gcctatacct tgcaaacagg ccgtgaagca 1829941 atggaggaac ggctggcctt tatagcggaa tcactagagg atcttgagag aaagctgaac 1830001 gattttatcg aaaacaaagc agacagcctg tatctggatc gcatcgatga taacaaaaaa 1830061 gcgttagcag tcttatcagc ggatgaggat acggaaaaaa tcatagaagc atggatgagc 1830121 aaagggaaat acacgaaact gctggatctt tgggtgaaag gcttgtcttt cgactggggc 1830181 atgctgtacg gcacccaaac gcctgtccgg atcagtcttc cggcatatcc atttgcaaaa 1830241 gaacgttact gggcaccagg cgcggcaaag gccccggtgt ctatagaaca ggatcatgat 1830301 cagcaaacag aagaaccttt caaggttatg acgtttcaag aagtgtggaa agaagagccg 1830361 gcgactctca catcgaaacg tatcaaaacg ctcatctgtt ttctgactga aagagaaaag 1830421 caaaacgcat ttgcttcagc cctgaaaaac gttgatcaag acaccaaggt catttttata 1830481 tcacagggcg aagtgtacag caaacagtct gaatatagct accagattgt gcggcaagaa 1830541 cccgttactt ttgaaaaggc cttccagagc attaaagaag aacttggaga gccagatgca 1830601 atcctctata tgtggcctat ggaagacaag cgctgtataa aggaccattc ctgtattgtt 1830661 tacctattac aaggtatgtc cgcagcaaag cttcatcctt cacggctgct gctggcagga 1830721 tgttttgaag atagtcttga ccgaagttat ctggaatcat ggattggctt cgaacgttca 1830781 ctcgggcttg tccttccgca cacaaaagtg actggaatct ttcagcccgc ggaacaagga 1830841 tcgatggatg attggacacg taaagtctgg gcagaattac aggcttcaac tgaacaaacg 1830901 gttttgtatc agaatctgaa acgatatgta aatcacattg aacagacaac gatacaaccg 1830961 gacaacagca aattgaagtc tggcggtact tacctgatta caggcggtgt aggagggctt 1831021 ggttatttat ttgccaagca tttggccaaa aactatgccg caaacctgat tttgacaggg 1831081 aggtcgcctt ttaatgatga gaagcaaaag caaataaaag aattaaagga tctaggcggc 1831141 gaagcgatgt atgcagaagc agatgtgtct gatcctatcg caatgggaga ctgcgtaaaa 1831201 agagggaaag accgattcgg tgccatcaac ggtgttattc atgcagccgg aatcgagagc 1831261 gactctgcta tttttgacaa aaagatcgaa agcttccagc gcatcattga accgaaaatc 1831321 aacggcacga tagcgcttga tgaatggctt aaaaatgaag accttgattt tatgtgttat 1831381 ttttcttctt cttctgcggt tttaggggat tttggatgtt gtgattatgc gattggcaat 1831441 aggtttcaga tggcttacgc acaatacaga aatgagctgc ataacggtaa aacgtttgtc 1831501 atcaactggc ctgtgtggaa ggatggcgga atgaagatcg gtgatgagga aacaacggat 1831561 atgtacctga aatcaagcgg ccaacgcttc ctagaagccg aggaaggtat ccgtatgttt 1831621 gagcacatcc tagctcagca ggatgctcag catctcgtga tagccggtca gcccagccgt 1831681 gtcagcagat ttttaggaat gactgaacca gctattccag aaccggccac tcaagcccct 1831741 ctagcacaag aaaacaagga tgaggtaaaa acactaagca ttgaaaagcg tttagaacac 1831801 gacttgaaag agcatattca cacattgctt aagatttcaa aggacaagct gaatttgaac 1831861 aaaaattggg ccgacttcgg atttgattcg atctatttgg ctaaattctc gaacgtgtta 1831921 tcaaagcatt tcaacatcga agtgacaccg gctttatttt tcggctattc aactttacaa 1831981 gaattgatca gctttttctt aaccgatcat aaagagctga ttgaagcatt ttaccgggat 1832041 gatgcatcag aggcgcaaaa gccccctgaa gcttatgcag taattcctgt agctttagaa 1832101 ccagaagcca gtaaaaaaag cattcggcag gttcacgatg agcctattgc cattatcggc 1832161 atgagcggca ggttccctca agctgattcg gtccatgagc tgtgggataa tctgaaaaac 1832221 ggtaaatcgt gtatctctga cattccgggc gaacgccggg actgggggag agctaacaga 1832281 gatccagaaa aagcagtgcc aaggtggggt gcatttttga aggacataga ccggtttgat 1832341 ccgctgtttt ttcaaatatc gcctaaagaa gccgaaagca tggacccgcg tcagcgcatt 1832401 tttctagagg aagcatggca cacgtttgaa gacgccggct atatgggaga tcggataaaa 1832461 ggaaaatcct gcggtgttta tgtaggtgtg gaagaagggg aatatgcgca tctaaccgga 1832521 gatacggatt acattaacgg aacacaaaac gccacattgt ctgcgagaat cgcatacgca 1832581 ttggatttaa aagggcctaa tatggctttg acagcagcat gttcatctgg actggtggcg 1832641 attcaccagg catgttcagc tctgcgtcag ggggattgtg aaatggcttt agcgggcggc 1832701 gtcagcttga atatttctca catgtctttt gaggcgctga caagggccga aatgctgtct 1832761 ccgaacggac aatgcaaagt gtttgaccag gatgccaatg gtcttgtgcc aggtgaagcg 1832821 gtggctgctg ttctcttgaa accattatca aaggcaattg aagataaaga tcatatttat 1832881 ggctgcatca aggccagcgg cgtgaattac gatggcaaaa ccaacggcat tactgcgcca 1832941 aatcctttta gccaggcaga attgatcgaa aacatttatg aaaaaaatga aatcaatccg 1833001 ctcgatattc aatatgtgat ggcgcacagt accggctcga atcttggtga tccgcttgag 1833061 gtccaagcgt taacgagcgt gttcagcaaa tatacgaagc agaagcaatt ctgtatgatc 1833121 agctcaatta aacctttaat cggacataca tttgcagcgt caggaacggt tgctttaatc 1833181 agtatgctga tggctatgaa aaaccagatc attccggcca ctcatcactg tgaatcggaa 1833241 aacccgtata ttccgtttaa agaaagccca tttgtgcttt gcaaagaaaa ccgttcgtgg 1833301 atcaagaaaa atcagaagcc gaggatggga acgatcagca cgactggaat cagcggcacc 1833361 aatgcacatg cagtcattga agaatacatt ccggatgatc agccgtccac acagcggcat 1833421 caagggtcac cgcagatctt tgtgatttca gcccaaaatg acgatcggct tcaggatgct 1833481 gcctgccgca tgattgcgta tctggagcag aatcataacc tttctttacc tgatgtggca 1833541 tatacgcttc aggttgggag aaaagccatg gaagcaaggc tcgcgatcgt tgcaaacaat 1833601 caggagcaat tggtgcgaaa attgaaggaa tatgtggaag caatgaagaa tggtggggta 1833661 tcaggccaac agagatccct ttatacagga tatacagaag ggattttaga agaacaagat 1833721 gaagcagttc tgcaagctct cgcaaaagaa agaaatttgg aaaacatcgc ggaatgctgg 1833781 gtgaaaggat atcagattcc ttgggaactc cttcatgatg gcgatgacgt tcggatggtt 1833841 tctttacctg gttatccatt tgcaagggaa cggtattgga tttcgtcagg cactcagcaa 1833901 tcagaggccg ttaaacagca ttcacaagat atgaaaacag agattgacga gccgaatggc 1833961 aaaacccata ttcaaaagat cattgttcaa tttttagcac gagaattggg catatctgag 1834021 gatcgaatca atttcaaaag aaacttcctg gattatggga tggattcaat tcttggccga 1834081 aaattgatgc ggcatatcga aaaaaccacg cagctgaaga tggccggccg ggaaatcctt 1834141 gaatgtcaga cagtccaagc tctatctgac catttggcct taaaagcgga aaaacaaaat 1834201 catagcgcag cagcacatca cataaagggc acgtatacag acgagcaaat cattggattg 1834261 atgcaagagg tggcgctagg gaaattggat tttaagagtg tgcaaaacat catagaaggg 1834321 agtaaatcgt atgaatcata aagaaattct cgatgccttc agatcaggag aattaaccat 1834381 ttctgaggtg gaagaacatc ttaaaggcat gaagcggcag ttgaaaagcc cgctttcaga 1834441 agggcaaaaa gggctgtgga tgcttcaaaa aatgtctcct gggatgagtg catataacat 1834501 tcctttatgc tttcgcttca gcaaaccaat acatgcagag acgttcaaga aagcccttct 1834561 gtttgtacag agacaatatc cggtcttagc cagtgtgatt caagaagaaa atggcattcc 1834621 atttcaatcg gttcagttat caaaggatct ttattttgtg gaagaggata tatcagcaat 1834681 gaaatcagca gatattatgc cttttctaaa agaaaaagca aaagaacctt tccagttgga 1834741 agctggtccg ttatggcgca cacacctttt tcatcggtta gaagaatgca ttgttcttat 1834801 aacaattcac catatcatat ttgatggtgt gtcgatgctg acattgatat cggcgctatt 1834861 cgaagcgtat caacaattgc tgaatgggat tgaacccttg cagcagccat caacagctga 1834921 ttattacgat tttgtcgatt gggaaaatcg aatgctgact ggcagagaag gggaagagca 1834981 tctcgcttac tggaaagaac agttgtctgg gagtctgcca gttcttgatt tgcctgctga 1835041 ccgtccgcgg tcttcagcac gaaaatttaa ggggcaagct tataaaagct tgctccctca 1835101 tcacctgaga aatcaaatta aatcgtttgc ccgcaccaat catgtgaatg aatcggttgt 1835161 gtttctctcc atttacaaag tgctgctgca tcattataca aaacaaaagg atatcattgt 1835221 tggcgttccg acaatgggtc ggcaagaaga cagatttgaa accctaatcg gttattttat 1835281 caatatgatg gctgttcgga gcaagaatat cggatctcag ccattaacag catttattcg 1835341 ggaactgcag ctgacagtgg ctgtcggcct ggatcatgcg gcgtttccgt tccctgcatt 1835401 ggtaagagag ctgaatgtag accgctcggc cgcggattct ccggtttttc aaacagcttt 1835461 tctgtaccaa aacttttttc aggcaacagg cttgcaaaaa gtgcttgaac cgtatcaaac 1835521 gcttggcatc gaatatattg aagacattcg gcaagagggt gaatttgagc tggcgctcga 1835581 aatatatgag caagaaaatg aaacagtgct tcatcttctg tacaaccctg atttgtacga 1835641 actgtcctcc attgaaagca tgatggagaa ctatatgaag ctcgcgcagc acatgatgga 1835701 ggacccgtct ttgccgcttg aagcctactc tttgcaatta aatcaagaac aaactagttt 1835761 gctggaacaa tggaatgcga cagggacaaa catcgcaaat gacaagtgta tacatgaggt 1835821 gtttgaggaa aaagcgaaac aaacccccga tgcggttgct gtgatgtttg aagacagatc 1835881 acttacatat aaagaagtag atgaaaaaag cacatctgtg gcagtctacc ttcaacatca 1835941 gggtgttaga cctgaacagc ccgttggcat ttgtgcagag cgttcgtttg atatgatcat 1836001 cggaatttta ggaatactga aagctggcgg agcgtatgtg ccgttagatc caagttttcc 1836061 gcaagaacga ttaaagtaca tgctcaaaga cagtcaggca tccattgtcc tcacccaacc 1836121 taacgttcat gataggatca gcggattaac tggcagccat gtaaaagcga tcaatatcga 1836181 gttagcttgc cgaaacggtt atacagacca gcaaagcagc ggtttaaagc gggaagtaaa 1836241 accggaacac ctcgcttata ttatttatac atcgggaagc accggagagc ctaaaggggt 1836301 tatggtagag catcggagca ttatgaatac cctgaatttt cttgaatctc actatcctgt 1836361 aacggctgag gatgcatatt tattgaagac gaactatgtg tttgatgtat cgatctcaga 1836421 attattcgga tggtttattg gagatggccg tctagtgatt cttccgccta atggggagaa 1836481 atcaccgcag ctttgcatgg attatattga aacatataaa gtgactcaca ttaattttgt 1836541 gccggccatg ctgcatgttt ttttagaaat ggcgaaagac aacaagcgat tcacagagga 1836601 cggtccgctg aagtatatga tggttgcagg tgaagccttc cctaaagtat tagtgaaaaa 1836661 ggcggtatcg ctctttacaa actgccgtgt tgaaaatata tacggaccga cggaagcctc 1836721 catttacgct gcgtatttcg gatgcggaaa aggagatatc gcaagtcacc atacaccgat 1836781 tggaaagcct gtttccaaca cgaaaattta tattgtggac cagcatttga agcctgtccc 1836841 gatcggaaag ccaggtgagc tttgcatcgc tggagccggc ttagcaagag gctactttaa 1836901 aaagccgggg cttacggctg aaaaatttat tgataatccc tttgaatcag ggacgaagct 1836961 atataaatcg ggtgattcag caaggtggct tcctgacggc aacatagaat acttgggacg 1837021 gattgacagc caagtcaaaa tacgcggttt tcgcgtcgag ctgggcgcaa tagaaacaaa 1837081 gctgggtgaa tttccgggca ttttagatca ggcggtagtg gtgaagcagc ttgagggcca 1837141 tcaacagctc gctgcttatt atacagagga aagcggacat gcctctgcca atccaaaaga 1837201 tttgcgcctt catctaaaat cgagtctgcc cgaatatatg ataccttcac actttatccg 1837261 cttagatgag cttccattat cgcccagcgg aaaagtgaac cgtaaagaat tagaaaaacg 1837321 cgagatcgtg ttcaacagaa ggaaaccaaa tcacttgcaa ttaacggaaa tagaggatca 1837381 ggtgctgcgc atttgggagg aaacgctcaa ggtcagcgga tttgggccgg aagacggatt 1837441 tttcgatgcg ggcggcgatt cgcttctggc tgtagctgtg gctgaacgaa tcaaaaaaga 1837501 attcgattgt gagtttcatg ttactgagct gtttgagtat tccacgatcc gtgcaatcag 1837561 tgaatacatt ttggagatga aaaactcaga tctagccggg acacaaaatg aagatgatca 1837621 tgatgacaaa aaagatggaa aatacccgaa acagaagatt cccccttatt ttgacgacag 1837681 tgttgcgatt gtggggatat cttgccagtt cccgggtgcg aaaaatcatc atgacttctg 1837741 gaaccacatc aaagaaggca aagaaagcat acgattcttt tctgaagaag agcttcgcgc 1837801 aaatggagtt cccgaagaat tgatacagca tcctgactat gtgcctgtgc aatctgtgat 1837861 cgaagggaaa gacttattcg atcccggttt ctttcaaatc tcgccaaaag atgctgagta 1837921 tatggaccct cagcttcgcc tcttattgct gcactcctgg aaagcgattg aagatgcagg 1837981 atatgtggct aaggagattc cggcaacaag tgtatatatg tctgcaagca gcaattcata 1838041 tagaacgtta ttgccgaagg agacaacaga aggacatgaa tcaccggatg gctatgtctc 1838101 ttgggtttta gcccaaagcg gaaccattcc cacaatgatc tcacataagc tcggattaaa 1838161 agggccaagc tattttgttc attctaactg ttcttcatca ctagtcggtt tatatcaagc 1838221 atacaaaagc ctgacatcgg gcgaatcaca atatgcgctt gtcggaggcg caacattgca 1838281 cgcacaatca gcgatcggct acgtgcacca aaacgggttg aatttttcaa gcgacgggca 1838341 tgtgaaggcg ttcgatgctt cggcggacgg aatggccgga ggtgaaggcg tagcagtcat 1838401 cctgctgaaa aaagctgtgg atgccgtaaa agacggagac catatttatg ccattatgcg 1838461 cggaataggc atcaataatg atggggcaga gaaggcaggc ttctatgcgc caagtgtaaa 1838521 aggccaaaca gaagtgatac agcatgtatt ggatacaacc aagatccatc ctgaaacggt 1838581 cagttatatt gaagcgcacg ggacgggaac gaaattaggc gatcctattg aaatgtctgc 1838641 tctaaataaa gtgtacaagc aatacaccga caaaacacaa ttttgcggaa ttggttcagt 1838701 gaaaacgaat atcggccatt tggatacagc tgcggggtta gccggatgta ttaaagttgc 1838761 gatgagttta taccataatg aacttgcacc gaccatcaac tgtacggagc cgaatccgga 1838821 tataaagttt gaaagctctc ctttttatgt tgtccgtgaa cgaaaatcgt tagagaaaca 1838881 cgcaggtgtc catcgggcgg ctctgagctc attcggcctt ggcggaacta acgcccatgc 1838941 aatatttgag caatatgaaa acatttctga tgcaggtgcc gaaaacgaag gcaatcagcc 1839001 ttacatcatt cctatatcag caaaaaatag tgaacggctc caagtatacg cgaaggaaat 1839061 gctgtcctat atcagtcaag acgagcaaag gcatttctct ttaagagata ttgcatatac 1839121 cttccaagtc ggccgtgaag caatggataa caggatcgtt tttatagtga acgatctgga 1839181 agagtggaaa catcagctgg aagcttttgt gactggaaag ccgctcgcag aaggctgtat 1839241 tcaaggagaa aaaacgagaa tgacatccgc tgaacagctg cttggaaatg ctgaagcaga 1839301 tgatatggct tcatcgcgga tatcaaaaga agaattgaga aagcttgccg agatgtgggc 1839361 aaatggcttt cacgttgaat ggcgcaggct ctatccaaat ataaagccac gccgcatcag 1839421 cttgccgaca tacccttttg ccgaagaacg atactggcct gaaagcagca ccggcgctat 1839481 cacaacaatt gaaccatctc gtttgcatcc tttggtgcac cataatacat cggttctgtc 1839541 agagcagcgt ttcagctcca ttttcacagg acaagagtat tttattgccg agcatatcat 1839601 taaaggcatg gcgattttgc cggcggcggt cacgcttgaa atggcaagag ccgctataga 1839661 acaaggaatt ggcggattgg aggatcatga aactggaatc aggctgaaaa atgtcgtgtg 1839721 ggttcgcccg gttgtagcag gaagtgagcc ggttcaggta aatatcggac tttacgatga 1839781 agatggcgga catattgctt atcggatgta tggtgatccg gaatccgctg atgcagaacc 1839841 agttgtatat aaccaaggta aagcggaatt gattcagtta aagcgagaaa aagcactgga 1839901 tctttctaag atcaagaaac aatgtgatca aagcaaaatg gatgctgcct cgttttatga 1839961 agggatgatc ggcgccgatt acggtccagg ttacaagagt gtagaggccg tatataaagg 1840021 cgacggccag ctgcttgcca aattatcact gccagaatct gttgcacata cgttgggcga 1840081 ttatgttctt catccaagtg taatggacgg ggcgttacag gcggctgaat atttgcaaaa 1840141 tgtcgtcaga gcggaacttt cagacactga agactttaag gcagcactgc catttgcact 1840201 ggaggaactt gaggtttttc gtcagtgcgt ttctgacatg tgggtttatg ttcaattcaa 1840261 ctcgaaaaac aaaccaggag atttgataca gaaagtcgat attcacctat gtgatgagca 1840321 tggcatgatc tgtgtgcggc tgaaaggatt ttcgacgaga gtgatggagg cagatataca 1840381 aaccgaacca tcaaaaatca acgctgaaac tttattgctt cagcccgttt ggcaagaaca 1840441 aaaggctgct aacagcttag ctgcaaaaaa atatgcagag catctcgtat tcctatgtga 1840501 atatgatcat gagacgagaa aacaaattga agcagccatc gaggatgtcc atgtatacag 1840561 cctggaagca aggccttctt cagtagatgg gcgtttccat tcttatacag aacaagtgtt 1840621 taaaaaggta caagagatca ttcgtacgaa accgaaagac ggcattctcg ttcagatcgt 1840681 gacctctgcc gagggagaac agcaattgtt ttcagggttg acaggactgc tgaaaacagc 1840741 ttgtcaggaa aatgccaaac taaccggcca aatgattgaa gtcagcagtg aagaaagtgg 1840801 agaaagcatt gctggcaaac tgttagaaaa tcaaatgagc agcgattcat atgtcaaata 1840861 tcaaaacggg acacggtata ttgctgattg gcgtgaaatc aaacaggcaa aaggagacgg 1840921 cagcaaaccg tggaaagaca atggcgttta tctcatttca ggaggtgccg gcggactagg 1840981 tcatattttt gcaaaggaaa ttgcggaaca aacgaaaaat gcgacagtca ttctggcggg 1841041 ccgctcacct cttagcgaaa gcaaaagcaa aaagctgaaa gagcttcata gcaagggggc 1841101 tgacatcacc taccggcaaa cagatgttac caataaaatt gaagtctatc agctcattga 1841161 cgacattcaa aaaagatatg gccgtctgaa cggtattctt catagtgccg gaatcatcaa 1841221 ggacagctac ctggttaata aacaggcaaa agatctgcac gatgtactgg cgcctaaagt 1841281 aaaagggctt gtttatctag acgaagcgag taaggatttg cctttagact tctttattct 1841341 cttttcatct ctttcaggaa gtttagggag cattggtcag tctgactatg cggcagccaa 1841401 tgtatttatg gatatgtatg caggctatcg aaataggctt gccgacctca gccagcggca 1841461 tgggcagacg ctttctgtaa actggccttt atggagagat ggaggcatgc aggtcgatca 1841521 agaaactgag aaaaggcttg tgcaacttgc cggtattgtt cctatgaggg cggaaaaagg 1841581 aattcaggca ttatatcaag cacttcattc agaggcaaac caagtaatgg tgatcgaagg 1841641 cgatgtgcag aaaataaaac aaaacatgct ggccaaaaac gcctcagcac ctatggaaaa 1841701 gaaggaagca gaacacatga ctgaacaaat aaatagcatt gatgcagaca gtttgctgga 1841761 taaagtaaag gcgatgttaa agcgagagat cgccaagctg ttaaaggtca agcttgaaac 1841821 gattgacgat catgcagaga tgacggtgta tggttttgat tctatctcca tgactgaatt 1841881 caccaaccat atcaatcgcg cctatcagtt agagctgacg ccaaccgtat tttttgacca 1841941 cccgacgatt catgcgtttg gcaagcattt gtcagaagaa tatcaatcgg tatttgcgaa 1842001 gacatttgct gtgcgcgctg tatcggctca gcttcagcct gctgcgaaac aggaacaagc 1842061 cgtgcgtgcc aaagctaaaa gacgcagaaa gcagcaagtc atgctgccaa acgccataca 1842121 gagtgatgct gggcctgagc caattgccat tgtgggcata agcgggattt tccctatggc 1842181 gaaagacgtt gaggcgtact ggaacatctt aaaagagggc aaagactgca tgacggaaat 1842241 cccgaaagat cgctgggatt ggcgtgaata tgaaggtgat ccggcgaagg aagtcaataa 1842301 aacgaacgtg aaatggggcg gttttattga cggtattgca gattttgatc cattattctt 1842361 tggcatttcc ccgcgtgaag ctgaacaaat ggaacctcag cagcgcttac tgctgactta 1842421 cgcctggaaa gcgatcgaag atgcaggata ttcggcgaaa aggttgtcag gcacaaaaac 1842481 cggcgtcttc atcggaacgg gaaatacagg atacagctct cttctatcta aagcgaactc 1842541 ggcaatagaa ggatcagcgg cagccaatac gagcccatcg gtcggtccga accgggtcag 1842601 ttatttcctt aatctgcatg ggccgagcga accggttgat acagcgtgct caagttcact 1842661 agtggcgatc caccatgcca tctcttcaat tgaggaaggc acttgtgaca tggcattagc 1842721 cggcggtgta aatacgatta tccttcctga ggtgtatatc agctttgata aggcgggagc 1842781 actgagcaaa gaaggaaaat gcaagacgtt ttcaaatcaa gccgatggtt ttgcacatgg 1842841 ggaaggtgcc ggcatactgt tcctgaaaaa attaaaagcg gctgaagaag cgggagacca 1842901 tatttacgga gtcataaaag gcagtgcaat caatcacggc ggccgtgcag cctctttaac 1842961 gactcccaat ccgaaggcgc aggcagatgt tattcagtcg gcatatcaaa aagcgggaat 1843021 cgacccgaaa accgtgacct acattgaagc ccacggaacc ggaacggagc ttggagaccc 1843081 ggttgaaatt aacggtttga aatcagcttt taaagcattg ggtgtaaatg aaggagacac 1843141 atcagccaat ccttactgcg gattagggtc tgtaaagaca aacatcggcc acttatcgct 1843201 ggcagccggt gcagcaggag ttattaaaat attattgcag cttaagcata aaaccttagt 1843261 gaaaagtctg cattgcgaaa acgtgaatcc atacattcag ctgaaaaaca gtccgttcta 1843321 tatcgtacgg gaaacggaag aatggaaagc gctgaaaaat gaacagggag aagagcttcc 1843381 tcgacgggca ggtgtcagtt catttggaat cggcggagta aacgcccacg tgattatcga 1843441 ggaatatatt ccggaagcat ccgatgagaa tataccatcc atcgcgccgg aacatccggg 1843501 tatcttcgtt ttatcggcta aaaatgaagc gcggctaaaa gaacatgcac agcagctggc 1843561 agatgcgctt gataagcaaa catatagtga cgtaaatctc gcccgaatcg cttatacact 1843621 gcaagccgga cgggatgcga tggaagaacg tctcgggatt atttccggtt ccattgagga 1843681 tttacagaaa aagttaaaag actttgcagc ggagaaaagc ggtgtggagg atgtatttaa 1843741 aggcaggatt gataaaggca cactccaaat gctgacagag gacgaagaga ttcaagaagc 1843801 cgtcgagaaa tggatggaac ggggaaagta tgcaaaattg cttgaattat gggtaaaagg 1843861 gcttgatgta gactggacga aattgtatgg cgagaatctg ccaaagcgca tcagcttgcc 1843921 gacgtatcct ttcgcaaaag accgttattg gatctctgat catattgaaa aaagcggcag 1843981 cattgatgca aatcaagcag cctcccgcct tggcggagcc gtgctgcatc cattaatgca 1844041 tcaaaacaca tccaatctct cggaacaaag gtttagctct atttatacgg gagaagagtt 1844101 tttccttgct gatcatgttg tgaaaggcca acggattttg ccgggagtgg ctcatcttga 1844161 attggcgcgg gcagctgttg agcaggccgc agaggtacaa ggtgtaccgc gcatcatgaa 1844221 gctaaagaat gcggtgtggg tgcggcctat tgttgtagag gatcagccgc agcaagtaca 1844281 cattaggctt ttaccgggag aaaatggtga gatctcttat gaaatctatg gtcattcaga 1844341 cgttactggc gaacagtcaa tcgtctacag tcaaggcagc gcggtattga atcctgctga 1844401 aaatttgccg gcggttgatt tgcaatctct gcgggagcag tgtcaggaaa gtcatttcag 1844461 cgtaaacgaa gtatacgaca cctatcgaat gattggattt gaatatggtc ctgcttatcg 1844521 cggagtgaaa aaaatctata cagctgaaca atttgttttg gcaaaattgt cattgcatcc 1844581 gtcagctgca gatacgctca gccaatacaa aatgcaccct gggctgatgg attctgcttt 1844641 gcaggcgtca agcattttga caggagccgg ggataaccag ctgacactgc cttttgcggt 1844701 ccaggagctt gaagtcttcg gagcatgttc gtcagaaatg tgggtatacg caagatacag 1844761 ccaaggcagc aaggcaactg ataaggtgca aaagcgcgat atggatattt tagatgagag 1844821 cggcaatgtt tgcgtacgga tgaaaggatt atctttcaga gcagcagaag gcggctctgg 1844881 atcggcggaa tctgatcaaa cgctggcaac cctgatgttt gaagaaaaat gggtgcccaa 1844941 ggattttaaa aaagaaagtc ctgagcctca ttacgaacgg cacattgtca tgctttgcga 1845001 catgaatggc ctctcaaaag atcgcattga atcaagaatg acaggagcgg aatgcatcgt 1845061 tttggagtca ttccgcgaag gacttgcaga gaggttccaa gattatgccg aacaagcgct 1845121 tgagacggtc cagggtcttc tcaaaagcag acctcagggc aatgttctga tccagctgct 1845181 tacctctgca caaagaaagc agtactcatt ctcagggcta tcggcgctcc ttaaaaccgc 1845241 cggcctggag aataaaaaac taatcggcca gacgattgaa atcgattcac atgaaaatgt 1845301 tgaaagtgta atagaaaaac tgaaagagaa taaaaggcac acagaagatc agcacatcaa 1845361 atatgaaaaa ggcaaacggt acatcaatga tctggatgaa atgcaaatag atgatcggga 1845421 aataagcatg ccgtggagag ataaaggtgt atacctcatc acgggcggcg caggaggact 1845481 tgggtttatt tttgcaaaag agattgctcg ccaagccgaa cagcctgtgc tcattctgac 1845541 aggcagatcc gcgttgaatg cggatcagca ggcggagctt aacgaacttc agcaattagg 1845601 ggctcgcgca gaatacaggc aggttgacgt gacacaaacg gaagcagcct ccgagcttat 1845661 cacaagcatt acgtctgatt acgaagactt gaatggtgtc attcacagcg ctgggctgat 1845721 taaagataac tatcttatga gcaaaaccaa tgaagagctg acacaagttc tcgctcctaa 1845781 ggtgaaaggg cttgtgaatg tggatgaggc aaccgagcat cttgcgttag atttctttat 1845841 cctcttttct tcaatatcaa gtgttgccgg cagcgcggga caggccgatt atgcaatggc 1845901 taatgcattt atggacagtt atgctgctta tcggaatgcg cttgtaaccg ccatgtacag 1845961 gcacggacaa acgttgtcaa tcaattggcc gctctggaaa gaaggcggca tgcgcgcgaa 1846021 taaagaaatt gaaaacatga cgttgaaaaa cacaggtgtg actccaatgc ggaccgagac 1846081 cggcattcaa gcgctgtata aaggtttggc atttggcaaa gatcaagtca tcgtcatgga 1846141 aggattcaaa gacatgatga gggaaaagct gactcaaaag ccgtcttctg atgatgtacc 1846201 aatgaaaaca gtgcaagtac gggtgacatc tgaagcaaga atggatcaag ggaatatgtt 1846261 tgaccacatt caagaagttt taaagcaaac aatctctcaa ttgctcaaaa tcaaacctga 1846321 agagattgac ccggacatgg agtttaatca atatggattt gattcgatta cgttaactga 1846381 attcgcaaat acactgaatg agaagtgcaa gctggatctt acgcctacgg tcttctttga 1846441 gcacgcaact gtttatgcat ttgcagggta tctgtcagaa gaatatccaa atgcttttac 1846501 agctcaaacg cctgccaaag ctgaggtgct gatgcagcct gtcgaacaga atataaaaaa 1846561 tatgacgttt tcgactgaaa accgctttgt aaaaccttcg gtaacaccaa tgcaaaagga 1846621 agctgatcac aagcctgagc ctattgcgat tgtggggatg agcggcgttt tcccaaaggc 1846681 aaaagacgtt gaggaatatt ggaagaacct gtcatcgggc gcagattgta ttacagaggt 1846741 tccaaaagac cgctgggatt ggcaggagta ttacggagac cctctgaaag aagcgaataa 1846801 aacaaacgtc aaatggggcg gttttattga tgaagttgct gactttgatc cattgttctt 1846861 cggcatatct ccgctggagg ctgagcagat ggagcctcag cagcgcctgt taatgaccta 1846921 tgcgtggaag gcggtagaag aagcgggaca ctcagcgaga agcctggcag gaaccaaaac 1846981 gggcatcttc atcgggacag gaaacacagg gtacagttca cttctgtcaa atgtagacat 1847041 cgaaggctca gcggctgcga atatgagtcc ttctgcagga ccgaatagag tcagttattt 1847101 cctgaacatt catgggccga gtgaaccgat cgacactgcg tgctcaagct ctttggtcgc 1847161 cattcatcat gcggtttgcg ccattgaaaa tggaaactgt gaaatggcga ttgcgggagg 1847221 ggtcaacacg gtcgtaactc cgcaaggcca tatcgcctat gataaagccg gggcgctgag 1847281 caaagaagga agatgcaaaa cattttctga caaagccgat ggattcgcag tcagtgaagg 1847341 tgccggcatt ctctttctga aaaagctgac agcggctgaa cgagacggtg atcatattta 1847401 cggtgtcatt aaaggaagtg cggtaaacca cggtggccgc gcaaattctc taacgactcc 1847461 taatccgaaa gctcaggcgg atgtcgtaaa aacagcatat gaaaaagcgg gaattgatcc 1847521 aagaaccgta acttatattg aagcgcatgg gactggaaca gagctgggcg atccagtaga 1847581 aatcaacggc ttaaaagcgg catttaaaga gctgtatgaa aaaacggggg acccggctgt 1847641 tcatggcagc cattgcggac ttgggtcagc gaaaacaaac atcggtcact tatcactggc 1847701 ggccggtgtg gctggtgtca ttaaagtgtt attgcagctc aagcataaaa cgcttgtcaa 1847761 aagtctgtac agtgaaactg ttaatccgta tatcagactg gatgacagcc cgttttatat 1847821 tgtgcaggaa tcgagagagt ggcaggcgct tcgggatgaa gccggccgag agctgccgcg 1847881 ccgcgcaggt atcagttcgt tcgggatagg cggcgtcaat gcccacgtgg tcattgagga 1847941 atatattccg aaagaaacaa cccatcctgc aacagcacca gccgtgacag cacagcaccc 1848001 gggcatcttt attttgtcgg caaaggatga agatcgtctg aaagaccaag cccggcaatt 1848061 agcagacttt atcagcaagc gatctatcac tgctcgtgac ctcactgata ttgcttatac 1848121 actccaagag gggcgtgatg caatggagga gagattaggg atcatcgctg tctcgactgg 1848181 ggacttgctg gaaaaactga acctctttat agaagggggc accaatgcga agtacatgta 1848241 cagaggcaga gcagaaaaag gtatcgcaca aacattgaga tcagatgacg aagtacagaa 1848301 aacgctcaac aatagctggg agcctcacat atatgaaaga ctgcttgatt tatgggtaaa 1848361 aggcatggaa ataggctgga gtaaactgta tgacggcaaa cagccgaaac gcatcagcct 1848421 ccctacctat ccatttgcga aagaacgcta ctggataacg gatacgaaag aggaggcagc 1848481 cgcccatcaa acagctttaa aaacagtcga atcagcagct ttgcatccat tgatacatgt 1848541 caacacatct gatttgtcag agcagcgttt cagctcggcc tttacaggtg ctgagttctt 1848601 tttcgccgat cataaggtga agggaaaacc ggttatgccg ggcgtggcat atcttgagat 1848661 ggttcatgct gccgttacaa gagcagtgag aagaaccgaa gatcaacaat ctgttattca 1848721 catcaaaaat gttgtgtggg tgcagccgat tgtggcggat ggccagcctg ttcaagtgga 1848781 tatcagtcta aatccccagc aggacggcga gattgctttt aacgtctata cagaggctgc 1848841 acacaatgat cgaaagatac attgtcaagg cagtgcttca atccgtgggg caggagacat 1848901 tccagtccag gatatcagcg cgcttcaaga ccaatgcagt ttaagcacac tctcacacga 1848961 ccagtgttat gaattgttta aggcgatcgg cattgactac ggacctggtt ttcaagggat 1849021 agatcggctt tacatcggcc gcaatcaagc cttggcagag ctttctctgc ctgctggtgt 1849081 aactcacaca ctgaatgaat tcgttcttca tccaagtatg gccgactctg ctttacaagc 1849141 gtcgatcggg ctaaagctga attccggtga cgagcagctt tctctgcctt ttgcgctgca 1849201 agagctagaa atattcagcc cgtgtacaaa taaaatgtgg gtgtctgtga catctcgtcc 1849261 taatgaggac aaaatacaga gactggatat tgatttgtgt gatgaacaag gccgagtgtg 1849321 tgtaagaatc aaggggatta cctcaaggct gctggaagaa ggcatacaac cgccagacgg 1849381 gccgacatca ctaggaaact ccaaagcaac tcttaacgga gcgcttctta tggcgccgat 1849441 atgggatcga gtgcagctgg agaagaggag catttcgcct gctgatgagc gtgttgtcat 1849501 cctcggaggg gatgacaaca gcagaaaagc tgttcaaagg gagtttccgt ttgccaagga 1849561 gctgtacatt gagccgaacg catcaattca tagaattaca ggccagcttg aagcactcgg 1849621 atcgtttgac cacatcgtgt ggatgtctcc ttctcgtgtg acagagtgcg aagtcggcga 1849681 tgaaatgatt gaagcccaag atcaaggcgt cattcaaatg tataggctca ttaaggcaat 1849741 gctttcttta ggctatggac agaaggagat aagctggacg atcgtgacgg tgaacacaca 1849801 atatgttgat cagcatgata ttgtcgaccc ggtcgatgcc ggggtgcacg gcctgatcgg 1849861 ttcaatgtca aaagaatatc caaattggca gacaaagctg atcgatgtta aaaaatacga 1849921 agacctgccg ttatctcaac tcctttcctt gcctgccgat caagaaggga atacgtgggc 1849981 ctatcgaaac aagatttggc ataagcttcg tctaattcca gtacacaaca atcaaccggt 1850041 gcacacgaag tataagcacg gaggtgttta tgttgtcata ggcggagctg gcggtattgg 1850101 tgaggcgtgg agtgaatata tgatcagaac atatcaggcg cagatcgttt ggattggcag 1850161 aaggaaaaag gatgcagcca ttcaaagcaa gctggacaga tttgcacgtc tagggcgagc 1850221 cccgtattac attcaagcag atgcggctaa ccgagaggaa ttagaacgcg cgtatgaaac 1850281 aatgaaacaa acacatcgtg aaatcaacgg catcatccat tctgcaattg tcttacaaga 1850341 ccgaagcctg atgaatatga gtgaggaatg tttcagaaac gttcttgctg caaaggttga 1850401 tgtaagcgtg cgaatggctc aagttttccg gcatgaacca ctggattttg ttttgttttt 1850461 ctcttccgta caatcgtttg caagagcttc cggacaaagc aattacgctg cgggttgcag 1850521 ttttaaggat gcttttgcac agcggctttc tcaagtatgg ccttgtacag tagccgtgat 1850581 gaattggagt tattggggaa gcattggtgt tgtttcatca ccggattacc aaaagagaat 1850641 ggctcaggca ggcataggct caattgaagc ccctgaagca atggaagctt tggaattgct 1850701 gctcggggga ccgctgaagc agctagtaat gatgaaaatg gcaaacgaaa cgaatgatga 1850761 agcggaacag acagaagaaa cgattgaagt gtacccggaa actcacggct ccgccattca 1850821 aaagctgcga agctatcacc cgggtgacaa cacaaagatt caacaactgt tataggaggg 1850881 gaaacgccaa tgctgaacac agaagacatt ctctgtaaaa tgcttttcgc acaattacag 1850941 tccatagggt ttttcacaga aagtaaatcc cagccggtat tggagaattt ctatggcaga 1851001 tggtttgaag aaagccaatc gattttagaa cggcatcaat ttctcaagcg aacggagaac 1851061 ggacatgttc caacacgctc aataggcacc atgagcgagc tgtggaaaga atggaatgaa 1851121 caaaaatttg acctgcttca agacaataat atgaaagcca tggtgacatt ggtggagaca 1851181 gcacttaaag ccttgccgga gattctgacc ggcaaggcgt cagccaccga tatcctgttt 1851241 ccgaattcat ctatggattt agtagaaggg gtctataaaa acaatcaagt cgcagactat 1851301 tttaatgatg ttcttgcaga tacgttaaca gcctatctgc aagaacgtct gaagcaagag 1851361 cctgaggcga agattcgaat attagaaatc ggagccggga ccggcgggac aagcgcggct 1851421 gtttttcaaa aattgaaagc atggcagaca catataaaag aatattgtta tacagatctg 1851481 tctaaagctt ttttaatgca tgcagaaaat aagtatggtc ctgacaatcc atatttgaca 1851541 tataaacgat ttaatgtcga ggagccggcg tctgaacagc atattgatgc gggaggctac 1851601 gacgcggtca tcgcggcaaa tgtgcttcat gccacaaaaa atatccggca gacattgcga 1851661 aatgcaaaag cagttttgaa aaaaaacggg ctgctccttt taaatgaaat aagtaatcat 1851721 aatatatatt cgcatttgac gttcggcctt ttagagggct ggtggctgta tgaggatcct 1851781 gatctccgca taccgggctg cccgggcctg tatccagaca cttggaaaat ggtgcttgag 1851841 agtgaaggat ttcgctatgt ttcctttatg gctgaacaat cgcatcaact cggccagcag 1851901 atcattgccg ctgaaagtaa cggagtcgtc cgtcaaaaga agagaacgga ggcagaagaa 1851961 gatccaagcc atatacaaat gaatgctgaa atcgatcatt cacaggaaag cgattctctc 1852021 atcgaacaaa cggcacaatt tgtgaagcat acgctggcaa aatcaatcaa actatcacca 1852081 gaacgtattc acgaagatac gacatttgag aagtatggaa ttgattcgat tttgcaggtg 1852141 aatttcattc gtgaattaga aaaagtgacg ggagagcttc caaaaaccat tttatttgaa 1852201 cataacaaca caaaagaact cgtcgaatat ttagtaaagg ggcatgaaaa taagcttcgg 1852261 acagcattgt taaaggaaaa aacgaagcct gcaaaaaatg aagctccact tcaaacagag 1852321 cgtacagatc ctaataagcc atttactttt catacacgcc gctttgttac agagcaggaa 1852381 gtcacggaaa ctcagctagc aaataccgaa ccactaaaaa tagaaaagac aagtaatttg 1852441 caaggaacac attttaatga ttctagtaca gaagatatcg caataatcgg ggtaagcggg 1852501 cgctatccga tgtctaacag tttagaagag ctttgggggc atttaatcgc cggagacaat 1852561 tgtattacag aggcaccgga atccagatgg cgcacatctt tattgaaaac attatcaaaa 1852621 gatccaaaaa agccggcaaa taagaaacgc tatggcggat ttttacaaga tatagaggca 1852681 tttgaccatc agctttttga ggtggagcaa aaccgggtga tggaaatgac accggaactc 1852741 cgtttatgtt tagaaaccgt ctgggaaacg tttgaggacg gcggctatac gcgaacccgg 1852801 ctggataaat tgcgggatga tgacggagta ggtgttttta tagggaatat gtataaccag 1852861 tatttttgga atatcccatc tttagagcag gcagtcctca gctcaaatgg gggagactgg 1852921 cacattgcaa atcgcgtttc ccactttttt aacctgaccg gaccgagtat cgctgtcagc 1852981 tcagcatgct ctagttcatt aaacgccata catcttgcgt gtgaaagcct gaaattgaaa 1853041 aactgctcaa tggcgattgc tggaggtgtc aatttaacac tcgatctctc taaatatgat 1853101 tctttggagc gtgccaatct gctgggaagc ggcaatcaaa gcaaaagttt tggcaccgga 1853161 aacgggctta ttcccgggga aggcgtcgga gctgtcctgt taaaaccact ttcgaaggcg 1853221 atggaagatc aggatcatat ttacgctgtg atcaaaagca gttttgctaa ccatagcggc 1853281 ggaagacaga tgtatacagc tccggacccg aagcagcaag caaagttaat tgtcaagtcg 1853341 attcagcagt cgggcattga tccagagact atcggctata ttgaatcggc ggcaaatggt 1853401 tcggcgctgg gcgatcctat tgaagtaatt gccttaacaa acgcgtttca acaatataca 1853461 aacaagaaac agttttgtgc gataggctct gtcaaatcca atctggggca tttagaggcg 1853521 gcttccggta tttctcagct gacaaaagtg ctgctgcaga tgaagaaagg gacgctggtg 1853581 ccgacaatta acgcgatgcc tgtcaatcca aatattaagc tggaacacac ggctttctat 1853641 cttcaggaac aaacagagcc atggcatcgc ttgaatgatc ctgaaactgg aaaacaattg 1853701 ccgcgcagaa gcatgatcaa ttccttcgga gcggggggag cctatgccaa tcttattata 1853761 gaagaatata tggagacggc ccctgagaaa gaacatatcg ctccccgcca gcaggaattc 1853821 actgccgttt tttcagccaa aacaaaatgg agcctgctta gctatctaga aaatatgcaa 1853881 ttgtttttag agaaggaagc ttctctggat attgaacccg ttgtacaggc tttacacagg 1853941 agaaaccata atttagagca taggactgca tttacagtgg catcgactca agagctgatc 1854001 gaaaaactaa aggtgttccg aacatcaaga gaaagctcac tccagcaagg catctataca 1854061 tcattcgatt tacagccatg tgcggaatca gcatctaggg atagagaaat aaacgcagca 1854121 gagcaatggg cacaaggggc attgattgct tttaaagaag ctgatatagg gaaccgaaca 1854181 ggctgggttc atctgcctca ctatgcattt gaccataata catcatttca tttcgatgta 1854241 tcgtctatca atgagaaatc gtcagatgtt gaagacaata tcaatcagcc ggtcattcaa 1854301 gatcaattca cttatgatga gccttacgtt caaggacacg tcttcaacaa tgaacgggtg 1854361 cttgtcggtg ccacatatgg cagtctggcc attgaagcat tttttaacct gttccctgag 1854421 gaaaacagcg gccgtatcag caaattaagt tatatcagtc caattgtcat caaacaaggc 1854481 gagaccattg aacttcaggc aaagccgctg caaaaagatc aagtcataga actgcaaatc 1854541 atgtatcgcg agccgtcctc tggtttgtgg aagcctgccg caatcggaca atgcggaatc 1854601 ggttcttttg agcccaaaaa agtcaatatc gagaacgtta agcattcatt aactaagctt 1854661 catcacatcg atcagatgta taaaaccgga aacggtcctg aatggggaga gttatttaag 1854721 acaattactc atctctacag agatcacaag tctatactgg caaaaattcg cctgccccaa 1854781 agcgggctgg caaacgggca ccattacact gtaagcccat tgatgacaaa cagcgcgtac 1854841 ttggctatcc tcagtttctt agagcagttt gacatgacag gcggcttcct gccgtttgga 1854901 atcaatgata tccagtttac aaagcaaacg ataaaagggg attgctggct tttgattaca 1854961 ttggttaaga atacaggtga catgttgctg tttgatgtag atgtgatcaa tgagtcgtca 1855021 gaaacagtgc tgcactactc gggctactcg cttaaacagc ttcgtatttc gaatcaaaga 1855081 ggaaatcaaa ataaggccat caaagccagc aatctgaaag ctcgtatcag aagctatgta 1855141 acagataaac tggcagtaaa catggccgat ccgtcaaaat tgtcaattgc aaaagcgcat 1855201 atcatggatt ttggaattga ttcttctcaa ttggttgcac tgacaaggga gatggaagca 1855261 gagacaaaga tcgaattaaa tccgactctg ttttttgaat atccgactat tcaagagtta 1855321 atcgactttt ttgcggacaa acatgaagca tcttttgctc agctgtttgg tgaagctcat 1855381 cagcaggaag aacgcccagc tcaaatcgaa aaccaaatga aacagattcc ggcatacgag 1855441 acgaacacgg ataaaacaat cgaacacgcg gcagacggca tagccattat cggcatgtcg 1855501 ggacagtttc cgaaagcaaa cagcgtaacg gaattttggg ataaccttgt ccaaggaaag 1855561 aactgtgtct ctgaagtgcc gaaagaacgc tgggactggc gcaaatatgc cgcagccgat 1855621 aaggaagggc aatcaagcct tcaatggggc ggttttatag aaggaatagg tgagtttgat 1855681 cccctgtttt ttggcatatc gcctaaagaa gcggcgaata tggacccaca ggagtttctg 1855741 ctcttgatac atgcatggaa ggcgatggaa gatgcaggct taacagggca ggttttatcc 1855801 agccgcccga caggagtatt tgtcgcagcc ggcaatacgg atacagctgt ggttccttcc 1855861 ctaattccaa accgtatatc ctatgcactt gatgtaaaag ggccaagtga atattatgaa 1855921 gctgcctgtt cctcagctct agtggctttg cacagagcta tacaatccat tcgaaacggc 1855981 gaatgtgagc aagccattgt cggggctgtg aatttgctgc tttcaccaaa aggctttatt 1856041 ggcttcgact caatgggcta tttgagtgag aaagggcagg ccaaatcctt tcaagcagat 1856101 gcaaatggct ttgtcagaag tgaaggagca ggagttctca tcattaaacc attgcaaaaa 1856161 gccattgaag attctgatca tatttattcg gttattaaag gttcaggtgt atcgcatggc 1856221 ggcaggggaa tgtcacttca cgcgccaaat ccggccggca tgaaggatgc aatgctgaag 1856281 gcttatcaag gagcgcaaat tgatcccaaa acggtgacct atatagaagc gcatgggatc 1856341 gcctctccat tggcagacgc gatagaaata gaggcgttaa agtcaggctg cagtcagctc 1856401 gaattggaac ttccacagga agtacgggag gaagcgccat gttatatcag cagcttaaag 1856461 ccgagcatcg gacacggtga actcgtctca ggcatggctg ctcttatgaa ggtcagcatg 1856521 gcgatgaagc atcaaacaat accaggcata tccggatttt cgtctttgaa tgaccaggtg 1856581 tcattaaagg gcacccgttt ccgagtgact gccgagaatc agcaatggag ggatttaagt 1856641 gacgatgcag gcaaaaaaat tccgcgcaga gcgagtatca acagctatag ctttggaggc 1856701 gtaaatgcgc acgtcatttt agaagaatat attcctttac caaaaccacc ggttagtatg 1856761 agtgagaatg gtgcccacat tgtagttctt tctgcaaaga atcaagacag gctaaaagca 1856821 attgctcaac agcagcttga ctatgtgaat aaacaacaag aactgtcatt acaagattat 1856881 gcttatacac ttcaaaccgg ccgagaggaa atggaagacc gcctggcgct cgtcgtccgc 1856941 agtaaagaag aactggtaat cggcttgcaa gcctgcttag cagaaaaagg cgataagctg 1857001 aagagttctg tacctgtctt tagcggaaat gcagaaaatg gctcgtcaga tctcgaagcc 1857061 ttgctggatg gtccattaag agaaatggtg atcgagactt tgttgtctga aaacaacctt 1857121 gaaaagatcg cgttttgctg gacaaaaggg gtgcaaatcc catgggaaaa gctttatcaa 1857181 ggaaaaggtg cccgcagaat accgttgcca acctatccat ttgaaaagag aagctgctgg 1857241 aacggctttc aagcagtaga gaatacgcct tctgtttcac aggatgagcg tatcaacaac 1857301 agcagcgatc atcacatatt agcaaatgta ctagggatgg ctccggatga actgcagttt 1857361 cataagccat tgcagcagta tggatttgat tcaatttctt gcatacagtt attacagcaa 1857421 ttgcaatcaa aggtggaccc tctcattgtc ttgacggagc ttcaagcatg ccatactgtt 1857481 caggacatga tggacttgat cgcaaagaaa caggaggata catccttaca aaatgatcaa 1857541 gctcgcacgt ttccggaatt aataccgtta aatgacggca agcgggggcg ccctgtcttt 1857601 tggttccatg gcggagtagg aggagttgaa atctatcagc aatttgcaca aaagagccag 1857661 cgcccttttt acggcattca agccagagga ttcatgactg attctgctcc tttgcacgga 1857721 attgaacaaa tggcttccta ttatatagag atcattcgat ccatacagcc tgaaggtcct 1857781 tatgatgtag gcggatattc cttaggcggg atgattgcat atgaagtcac tcgccagctg 1857841 caaagccaag gccttgctgt caaaagcatg gtgatgattg actccccata tcgttctgag 1857901 acaaaagaga atgaggcatc tatgaaaacg tcaatgctgc aaacaattaa tacgatgctg 1857961 gcatcgattg cgaaacggga aaagtttacg gatgttctca tcagccgtga agaggtggac 1858021 ataagcttag aggatgaaga attcctgtct gagttgattg acttggcaaa agaacgaggg 1858081 ctaaacaaac cagataaaca aatacgtgcg caggctcagc aaatgatgaa aacacagcgc 1858141 gcctatgatt tggagtcgta cactgttaag cctctccctg atcctgagac ggtaaaatgt 1858201 tattatttcc gcaacaaaag caggtctttc tttggtgatt tagacactta tttcacttta 1858261 tcaaatgaaa aagaaccgtt tgatcaagct gcctattggg aggaatggga gcggcaaatt 1858321 cctcatttcc acctggtgga tgtcgattca agcaaccact tcatgatatt aaccgaaccg 1858381 aaagcgtcaa cagccctgtt agaattttgc gaaaagctct attcaaacag gggagtagtg 1858441 aatgcgaatt tccttaaggc tttccggaag aaacatgaag cgagggaaga aaaagaaaca 1858501 gatgaattgg tgaagcgctg agaaaacaca aacgccccct cttttaaaag ggggcgtttt 1858561 gaatgttatt ttgaaagtga aacagggaga ctttctaatc ctcttaaaaa gacatttttt 1858621 ctccattgaa tgtcatcagg tgcaaccgca agttcaatat caggaaatct cttcaaaagt 1858681 gctttaaatg caatgtggcc ttccagcctg gcaagaggcg ctcctaagca gaaatgaatg 1858741 ccaaaaccaa aagaaatatg tctattaggc gaccgattta tatttaatat ttcggggttc 1858801 tcaaaaaaat tcgggtcgcg attggcagat ccgatgccta taaaaatcat gtctcctctt 1858861 ttgatcgaat gccccttata tgtaaagtct tcgatggccc accgatttgc catcataacg 1858921 acaggtgagg tgtatcgcag caattcttca accgctgtag cgatcatttc aggctgctgc 1858981 ttgagcttct cacattcctt cttgtgctgc agcaatgcga gggtgcctga gccgagtaag 1859041 ttaacagttg tttcaaggcc ggctacaacg agcaagaaca gcatcgaata gagctctttt 1859101 tcgcttaact tgctgccgtt ttcctcagca tgcacaagtt tgctgattaa atcgtctttt 1859161 ggctttattc ttctgtcatg gatcagctta gcgatataat ctttaaattc acgaagggcc 1859221 tgatttgtca gctctctatt accttcagag gtatcaacca tcgcattggt ccagatttga 1859281 aactgtgacc gatcttcttt tgggattccc atcaattcag atataacaat aaaaggcaaa 1859341 ggggaagcga aggatttcat gatatccgct ttattttctt tttccatttc atctaaaagc 1859401 tgttcagcaa tttgttcaat gctgccgcgc agattttcaa tggttcgggg agtaaatgct 1859461 tgatgaacaa gtgatctcag gcgggtatgg tcaggtgtgt cttttgccag catatgatcg 1859521 gatacaaaat cgatatcttc actaacgttg agcattttga tttgttcttg gttcatcaca 1859581 ttttttacgt ctcttgtaat tcgattgtct tttaaaaagg ccatacaatc atcgtatcgg 1859641 gtaattaacc aggccggata tgtggctccg aaccgtttta attcaaatcg gtgaatgggc 1859701 tcttcctctc taaatcgtcc taaaactgaa aaaggattgt gatgaaactc tttaccatgc 1859761 ggatgaaaca tcaatttttc catttgcatt ctcctcgcct aatagggtaa atagatgaat 1859821 caaattgctg aattagttta caaaaaacag aatgatttga aatgtaatcc tgtctctaaa 1859881 actatatatc tatcttaggc gtcattcaat agggagaaga acgaaaaaag tgaaaaaacg 1859941 gctcgatata aagcagcgcc tttgaacgaa agctcaaagg cgctacgctg tattattttg 1860001 atgaaagtgg ctgtcagctg tgctggatat caattgtata tactgcacga tctgttacga 1860061 ccttcaatcc ttcgttttct tggtgaatat gaagctcacc taataaagga atctcatagg 1860121 cattttgcgg aagcggtacg tttccgtcct cagtgaatgt tgttccttcg ccttctaaaa 1860181 caagctcttc tttcgcaaca taatcatcag gatgattcgt actgcgtata gccacttttt 1860241 gaaggtggag aacaatctga tccaagtctg atatctcttc atcatgggtc aattcacctt 1860301 ttctaatatc aagcgtctgg ccgacttttg attccagcca ttgagaaagc tgtgtattcg 1860361 tgtgtgccat caatattcct ccttttgatc tacacgatac tattcccaat tgctgcatct 1860421 tttacacggg aaagagccgc cccactcttt atgtatgaaa cagttcgctg ttgagtgcct 1860481 tgatatagcg tacggcagaa cgctggaccg attcgtcggc attttctttg acaactttag 1860541 agaaagcatt gtaaagccgg ttgaattgaa gcggttttac tttggctgct atttcttcaa 1860601 ctttggaggc gggaagggga atgagatttg ggtagctgta cataaagctg acccagtttc 1860661 gatccgccgc aaccgtaatg atatctccgg tcaatagaca gcctttccct tcattgccct 1860721 tgctccaatg caaaacagca ccgcctttaa aatgtccgcc cagtcggtaa aggtccagtc 1860781 ccggcttcat attgagcgtt tcccctgacc agaagtgaat gtgattgctt ggccttgtca 1860841 cccattcttt atcatcctca tggatataga tcggcgcctg aaacgcttca gcccactcaa 1860901 cctgagtaga gtaataatgt ggatgagaca aggcgatggc ttgaataccg cctaattcgt 1860961 tgatttggtc aattgtcttt tggtcaagat atgtcatgca atcccacagc acattgaagc 1861021 ccttatgctg aataagatgg gctgtttgtc caatcgcaaa ctctggttca gttttgatgc 1861081 tgtaaagatg ctcttcttcc tttttaagga tgttttgaag gtttcctttc tcacgcatgt 1861141 cttcaagggt tgtccaagtt tgtccatcgg gatgaatata ctgtctttca tcctcgcaaa 1861201 tcagacacga gttgggcgga tctacagtct gtgcatgttg cacaccgcat gtattgcaga 1861261 tataatatgg cactttcttc acttccttca tctattttcc attattttac cttatgatta 1861321 tgaatattca aacgaaaaaa ccggcagttc tgctgagaga gaattgccgg cttttgatga 1861381 tgtttattgg ccgggaacgg aattttctgc gttgacagcg cccgctccgt agatattcgg 1861441 atcttcatct ttccatttgt ccgtgccgtt tttcaaaagc tcttttactt catcaggggt 1861501 aagatccggg ttttgctgaa gaattaaagc tgcgattcct gcgcaaatcg gtgttgccat 1861561 cgaggttcct gacattgtaa agtactgaga ccctacacgg cttgactttt ggagcttatc 1861621 aatataagaa ttcggagagc gaagggaaat aatattaaca cccggcgcta aaatatcggg 1861681 cttttctttc ccgtatactg tcgggccgcg gcttgagaag gaagcgacag tatcatcatc 1861741 gctgcttgca gtattgttat cgtcaagcgc acctactgta atcacctttt cgctcacgcc 1861801 cgggcttgca atggtctgcg aatcagggcc tgagtttccg gcagcgacac agacgacaat 1861861 ccctgcgctc cacgcttcct caaccgctct gactaacgga tcttcctgtt catgatcata 1861921 tctaagggca tcgcccccga gcgacatgct cataatatca atcggttcat cggggttgtc 1861981 ctcattgtat tgaatacacc actcaacacc ctctataata tctgctaacg ttcctgaacc 1862041 ctgcttgttt aataccttta cgccgatgag attggcttcc ggtgcaggtc cgcggtattg 1862101 accggaagag gatgcaccgc tgcttgcgac atcacctgca cagtgtgtgc catgaccatt 1862161 atcatcgtac ggctctgttt tttgattgac catgtccgcg aatccgataa ttcttccttc 1862221 tagatcagga tgcgggtaga ttcctgtatc gacaacagcg acagtaacac cttttcctgt 1862281 cagggtttgc ccgtttctga cgacttcctt cgcatggctt gcttcggttg ccgtgtctaa 1862341 aagcgctttg acttcgcggt ttaaatacac tttacggata ttgctgcatt cagagagaag 1862401 ggaatgtaat gctgaaggag taacctcggc gctgcagcag ttgattttgt tgaagcggct 1862461 ttttagcttg ctgcgttttt ctttttgcag cacctctcca gccatttgaa agccggtctc 1862521 gtgacagcct tcctcaaatt cgataatgac tgacattttt tttctgtttt gcaatttggt 1862581 ttcgaaaaat ttatgcaaga agcaaggagt ccatttgaag ggcttgtaaa gttgcaatac 1862641 ggtttcccgt aacggccaat ctagcttgtg agcatttgct ctcaccattt gtaccataga 1862701 gtacccaaac atgtattttc ctcctattat aaggttctct gtatactcta tgaacagatg 1862761 ataggtttgg taagtttgtt tgtcctctgt aagagacaga caagagtttg tttttctgaa 1862821 tctttcgcat tagatacgat agattcagaa gctgaggaaa tcattgggga ttgaaaaaga 1862881 acgtttgttc gtattataat gtgatcatat caaactggga aggggagagc aaccgtatga 1862941 atttctactt gcaccgatct ttggaaagcc aaatgccaat cagcattata tatgaagaaa 1863001 gacggaacga ttagtaaaag aacgattatt gtgagacaga aaagcaaaac gaaaatcaaa 1863061 gcattttgtt tttcgaaaca acagatcaga acatttttat tggactctat cctctcctgt 1863121 gattttgtga gaacaaataa gcaaaatctc tattctgcag gccggtaaca gctgtccgtc 1863181 tcagcaaccg ggcagcctgt tactaaaacc ctccttaaac ctatatacat ttatttgcca 1863241 agtgaggttg ttcctacctt ttttgtcttt cctctcaacc ttttttcact cttatttgaa 1863301 atgaaccgct aataaccgtg acaatcaatt gattttttga aaccgggaac tttttcactg 1863361 atgatattgt gtatacaatg gtaagataaa acctattggc taaacctcat ataatgaacc 1863421 gcgccattct tatgaaagga gttaaacatg agaagatttt tactaaatgt catattagtc 1863481 ttagccattg tcttgttctt gagatatgtt cattactcat tggaaccaga accatcaaat 1863541 cagccagata catattcaaa tttcagcagc ttggcagaga atgagagccc agccgattac 1863601 gatatttcat ataatgagaa aaaaggaagc aaagtcttaa ttatgtctcc gcatggcgga 1863661 agaattgaag gcggagtaag tgagcttgtg cgttatttca ataatgaata ctctacatac 1863721 ctatttgaag ggttgaagtc ccatgataac caaacactgc acattacaag caccaacttt 1863781 gatgagccat tggcaaaaaa gaaaatcaag gagcatcaat atgtggtggc ttttcacgga 1863841 tataaaggag agaacaagaa tacccttgta gggggaacag accgaaagcg ggcgaaaatg 1863901 attgtgagag cccttgagcg gagagggttt tccgctgagt tagcgtcgtc taaaagcggt 1863961 cttgctggat tgaatgccga aaacattaat aaccaagggg aaacggggct aagtatccag 1864021 ctggaaatca gccgtgagca gagagaagca ttttttgatg atttttatta taaaaataga 1864081 aaatacacaa agaacagtga attttatgct tatgtcagtg cgatcaaagg tgtcctggaa 1864141 aaagagtatt cgtaacaagc agatcagaag acaaaataag agaagatcag tagactgaaa 1864201 taggataaaa aaggaggcaa aacaatggca gatcatcatt tttatttaaa agcgaactgg 1864261 ccgggtaacc gtaatgatgt cggtacgatc gaaagcggaa acctgatcac atcgatttcc 1864321 attcctaaag aaatggatgg cccgggagaa gggaccaacc cagatgaaat gcttctcggg 1864381 gcggcagcga cctgttacat tattacactt gcagcgatga tggagagaag cgggctggaa 1864441 aaagaagact tacagatgga gtcagaaggc attgtcaacg ttacaaaagg agtctttaca 1864501 tacaaaaaga tcattcaccg tccctctgtc gtgcttaaac atgatgcttc acaagacgac 1864561 gtcgcattgg cgcacaaact ttgtaaaaaa gcggagtcgt catgcatgat ttcgcgtgca 1864621 attcaaggaa atgtcgagct gcagcttgaa gcctctgtga aactgggtgg agaataaaga 1864681 aaacagacgg tcactcacag gccgtctgtt ttttatcttc agcgtgggct ttcgattgat 1864741 ttagcacgac cacgcctgca atgacaagcg tgagaccgaa tacacctttt aaactgatgg 1864801 tttcgccaaa aagcaaaaac ccgacaattg ctgtaagcgc ggtaccaacg cccgaccatg 1864861 ttgcatacgc gcttgataag tcaattgttt ttaaagaaaa gcttagaaac gtaaaagcag 1864921 aaagaaatcc gactatgact ccggcaatgg gccaggcttg tgtaaatcct tctgaaagct 1864981 tcaacatcgt gctcccaaac acttcagata caatggcgag agccaaataa agcaatcctc 1865041 tcatcttcat cactccttta cggccaatta agtaacacga cccctgatag taataaaaga 1865101 atcccgataa gccctttggc attcagatct tccttgaacc attttactcc gatcactgtc 1865161 gtcagcaccg tgcctgcccc gctccaagtc gcataggaga ggctcagggg aatatggttt 1865221 aaagtcaggg acagcatata aaaggcgagg gaatagccaa taacgaccaa agcacttggc 1865281 ttccactttt tgaagccatc agatactttc agcatggctg ctcctatcga ttccgaacat 1865341 atggcaatcg tgaggaatat atatcctatc aacatcatga attctcctca ctatattttt 1865401 agattagaaa aaaaacttca gctagaaaaa tattagtgta tgcctatgta tgagtcaaga 1865461 gattcatttt cacacactta aaaagacccc tttttaaggg gtcttttgcg tttaataata 1865521 aaaagggaac ggggcatacg gataataggg gtatccgcca tacaaataag gattaaataa 1865581 agcgcttcct ataagcccgc ctgcaaggcc gccgataaac ggtcctccaa aaaatccgaa 1865641 tggccggcca aacccataac caaatccggg tcttccaaac ccgtaaccga acccgaacgg 1865701 tcttccaaac ccaaatggtc tcccgaatcc gaacggcctt ccaaatattc ttgtatcttc 1865761 agggctgaaa tgctctaact cgttcatgtt ttctttcctc ctgtaataaa gtgtagatga 1865821 tgcagtgtat tcaccctgcc cggatttgat tgggcgaatc gaggaaaagg aggatgtgaa 1865881 cacattgggc ctgtatcagt ctgactggtc aaaagcaccg ccccacgcac atgcttatca 1865941 tgtcaaaaca acgagagaac agggccatta tcatctcatc gaagggttta ctcagccggc 1866001 aaacggatca aataccgatc agcatacaca ttactataca gggatcactt catttgaaaa 1866061 cggccatttt catcggtatt acggaatctc aggaccggcg attcccttag cagatggcac 1866121 acattatcat gaaatcgaag aaacgacgta tctggcctat aacgagccga ttgagatcca 1866181 gtacggaggg gttgtgtacg atcccggaga tgacagaaga aaaacgcatc gtcataccct 1866241 gaaaggaaag acaagggaaa ttgtcggcaa tgagccgctc ggctggtaga aggatgttta 1866301 ccgatgcaaa aaaagggcaa aatggatagg tggttgtcca tgttgaatgc tataatgggg 1866361 ggagatttat aaaagagagt gatacatatt gaataatacg aagcagcccg ttgtcatttt 1866421 agtcggaccg acggcagtgg ggaaaaccaa tttaagtatt cagctagcca aatccttaaa 1866481 cgcggaaatt atcagcggag attcgatgca gatttataaa gggatggata ttggaacagc 1866541 taaaattacc gaacaggaga tggagggagt gccccatcat ctgattgaca ttttagatcc 1866601 ccaagactct ttctctactg ccgattatca aagcttagta agaaataaaa tcagcgagat 1866661 tgcaaataga ggaaagcttc cgatgattgt cggcggtaca gggctttata tacaatctgt 1866721 gctttacgat tatacattta cggaagaggc aaatgatccc gtgtttcgag agagcatgca 1866781 aatggctgct gagcgggaag gcgctgactt tcttcatgcc aaacttgctg cagcagatcc 1866841 cgaggcagca gctgcgattc atccgaataa tacaagaaga gtcattcgcg cactggaaat 1866901 tttacatacg tccggaaaaa cgatgtccca gcatttgaag gaacaaaaac gagaacttct 1866961 gtacaatgca gtgttaattg gcctgacaat ggatagagac acgctttacg aaagaattaa 1867021 tcagcgggtc gatttgatga tgcagtcagg ccttcttccg gaagtgaaac gcttatacga 1867081 caagaacgtg agagactgtc aatcaataca ggcgataggc tataaagagc tgtatgcata 1867141 ttttgacggt tttgtgacac tttccgatgc tgtcgaacag ctaaagcaga actcgaggcg 1867201 gtatgcgaaa cgccagctga cgtggtttcg caacaaaatg caggtcacat ggttcgatat 1867261 gacaccgcct gttgatatgg agctgaaaaa aaaggaaatt ttcacacata tagcaggaaa 1867321 actcgaactt taatcgaaac tgtatgatat agagaatcaa ggaggacgaa acatgaaacc 1867381 gattaatatt caggatcagt ttttgaatca aatccggaaa gaaaatacgt atgtcactgt 1867441 ttttttgctg aacggctttc agttgcgggg ccaggtgaaa ggctttgata actttaccgt 1867501 attgttggaa tcggaaggta agcagcagct tatatataaa catgcgatct caacgtttgc 1867561 gccgcaaaaa aacgtccagc ttgaactcga atagatcaaa aaatgccatg tcaagacatg 1867621 aggaaaggct gtcgggggtt cccggcggcc atttttaaca tgaatccact tttgctccaa 1867681 gctttttgtg taagctgacc atgccaaggc acggtctttt tttatgagaa caacatacgg 1867741 aagtaaaaat ggtatattat gtataaaatg aatttgggag tgatcgatct tgtttgaaag 1867801 tgaagcagaa ctgagacgaa tcaggattgc acttgtatgg atagctgtct ttttactgtt 1867861 cggggcgtgc gggaatcaag ataccattat tgaaacagac aacggcaatt cagactatga 1867921 aacgcctcag cccacctcgt ttccacttga acataaccat tttggcgtta tggaggacgg 1867981 ctatatcaaa atttatgagt ataatgagtc ccgcaatgag gtaaagctga agaaagaata 1868041 cgcggatgat gagcttgaat aaaattcaca agcattcgaa tttacaaagc ggatgccagc 1868101 cgctaaacta aatacagaca cagatcaaac agagggtgaa aacatgaagc ataaagtgat 1868161 cgtgaatcat tgggaagaaa tttgcgaaga tgattcttgc tatgaatacg gaacaagtat 1868221 cattgtgaac ggaaaagaat taatcagaga agcgtcaatt atcactgctt tgaaggcggt 1868281 tttagaagag atcggcgcgg atgttgaaat agaagaaaca gtagagagcg aaaaatgctg 1868341 tgatagctta agaaaaaaaa atctagacta ctaagcagtt ttttttcatg ttatgatata 1868401 catcggctaa aaacgacacc ccgagtagga cgagagatga ttctcgttct gctctctttt 1868461 ttgggcccta atgagtctgc ccgtttgcct gatttgatca aaatatgaat ttttcataaa 1868521 aacgaatcta tatattgtgt ttttgctaga gggtagtata ctatatatag tgttagtgat 1868581 gagagattca tattttttga taggtcgtga taaaacgtgg tacaaatcat atttgattcg 1868641 aaaacaggga atgttcagcg gtttgtgaat aaaacaggct ttcagcagat acgcaaggtg 1868701 gacgaaatgg accacgtgga cactccgttt gttttggtca cctacacgac aaacttcggc 1868761 caggtaccgg catcaacaca atcatttctc gaaaaatacg cccatctctt attgggagtc 1868821 gctgcgagcg gcaacaaagt atggggcgat aactttgcaa aaagcgccga taccatttca 1868881 agacaatatc aggtgccgat cttgcacaaa tttgaactca gcggcacatc taaagacgtt 1868941 gaattgttta ctcaggaggt agaaagagtt gtcacaaaat caagtgccaa aatggatcca 1869001 gttaaataac gaaatcatga tccaaaaaga tgggaaattc cagtttgata aggataaaga 1869061 agctgtacat agctattttg tagattatat caatcaaaac acagtcttct ttcacaattt 1869121 aaaagagaag ctggattatt tggttgaaaa ccaatactac gaagaggaat tcttaagcct 1869181 ttattctttt gaagacatta aagaagtgtt taagacagct tacgctaaga agtttcgttt 1869241 tccttccttc atgagtgcgt ttaaattcta taatgactat gctttgaaaa cgaatgacaa 1869301 gaaaaaaatc ctcgagcgtt atgaggaccg gatctcaatt gttgcgctgt tcttcgctaa 1869361 cggcgacact gagaaagcaa aagaatatgt aaacctgatg atcaatcaag aatatcagcc 1869421 gagcacaccg acatttttga atgccggcag aaaacgccgc ggtgaacttg tgagctgctt 1869481 cttgctcgaa gttaatgatt ctttaaatga catttcaaga gcaatcgata tctccatgca 1869541 gctttctaag cttggtggcg gggtttctct taacctgtcc aagcttcgcg cgaaaggtga 1869601 agccattaaa gatgttgaga atgcgacaaa aggcgttgta ggcgtcatga agcttcttga 1869661 taacgcgttc cgttacgctg accaaatggg acaaagacaa ggctccggcg cggcgtattt 1869721 aaacattttc caccgcgata tcaatgattt tcttgatacg aaaaagattt ctgcggatga 1869781 agatgtgcgt gtcaaaacgc tttcgatcgg tgttgtcatt ccggataagt tcgttgagct 1869841 tgcacgcgag gacaaagcgg cttatgtatt ctacccgcac acgatttata aagagtacgg 1869901 ccagcacatg gatgagatgg acatgaacga aatgtacgac aagtttgtcg acaaccctcg 1869961 ggtgaaaaag gaaaaaatca acccgcggaa actgcttgaa aaattggcga tgcttcgttc 1870021 tgaatcaggc tatccataca tcatgttcca agataacgtc aataaagtgc atgcgaataa 1870081 ccatatttcc aaggtcaaat tttctaacct ttgctctgaa gtgctgcagg catctcaagt 1870141 ttcttcatac acagactatg atgaagaaga tgaaatcggt ctggatattt cctgcaacct 1870201 gggttcgctt aacattctca atgtcatgga gcataaatca atcgaaaaga cagtcaagct 1870261 tgcgacagac tctttaacac acgtgtctga aacaacagac atccgtaatg cgcctgctgt 1870321 aagacgggca aacaaagcga tgaaatcaat cggcctcggt gctatgaacc ttcacggcta 1870381 ccttgcgcaa aacggcattg cgtatgaaag tccggaagcg cgtgactttg caaacacgtt 1870441 ctttatgatg gtgaatttct actccatcca gcgttctgcg gaaatcgcaa aagagaaggg 1870501 cgaaacgttt gatcaatatg aaggatcaac ctatgcgaca ggtgaatact tcgacaaata 1870561 cgtttcaact gatttctcac cgaaatacga aaaaatcgct aatctgtttg aaggtatgca 1870621 tatcccgacg acagaggact ggaaaaagct aaaagcattt gtcgctgaac acggtatgta 1870681 tcacagctac agattatgca ttgcgccgac aggctctatc tcatacgttc aatcaagcac 1870741 ggcgtctgtt atgccgatta tggaacggat tgaagaacga acatacggca actcaaaaac 1870801 gtactaccca atgcctgggc ttgcatctaa taactggttc ttctataaag aagcctacga 1870861 tatggacatg ttcaaggttg tggatatgat cgccactatc cagcagcaca ttgatcaggg 1870921 aatcagcttt acattgttct taaaagacac aatgacgacc cgagatttaa accgaatcga 1870981 tctgtatgca catcatagag gaattaaaac catttactat gcaagaacga aagatactgg 1871041 gcaagacagc tgcctttctt gtgttgtttg attaaaggag agtttatagt gacaaaaatt 1871101 tatgacgcag caaactggtc aaagcatgaa gacgatttta cccaaatgtt ctataaccaa 1871161 aacgtgaaac agttctggct tccggaagag attgctttaa acggcgatct cctcacatgg 1871221 aagtacctcg gaaaaaatga gcaggacact tatatgaagg tactggccgg acttacgctt 1871281 cttgacacag agcaggggaa tacggggatg ccgatcgtgg ctgaacacgt agatggccac 1871341 cagcggaaag cggtgctgaa ctttatggcg atgatggaga acgctgtcca tgcgaagtcg 1871401 tactctaata ttttcatgac ccttgcaccg actgaaacga tcaatgaagt atttgaatgg 1871461 gttaaacaaa ataaatattt gcagaaaaaa gcgcaaatga ttgtcgggct ttacaaagcc 1871521 attcaaaaag atgatgaaat ttcactgttc aaagccatgg ttgcttccgt ctatctggaa 1871581 agcttccttt tctacagcgg tttctattat ccgttatatt tctacggaca aggaaaactg 1871641 atgcaaagcg gtgagatcat taacctgatc cttcgtgacg aagcgattca cggcgtgtat 1871701 gtcggtctcc ttgctcagga aatttataat aaacagacag aagagaaaaa agcagagctt 1871761 cgtgaatttg cgatcgacct cctgaatcag ttatatgaaa atgagcttga gtatacagag 1871821 gacttgtacg atcaagtcgg gctctcacat gatgtaaaga aattcatccg ctataatgcg 1871881 aataaagcgc tgatgaacct tggatttgat ccatacttcg aagaggaaga cattaatccg 1871941 atcgttttaa acggattaaa cacaaaaaca aaatcgcatg acttcttctc tatgaagggg 1872001 aatggctata aaaaagcgac agttgagccg ctcaaagatg atgactttta ttttgaagat 1872061 gaaaaagagc agatataata tctgctcttt tcggcttgaa ggttcaaatg aggaggacgc 1872121 agtacccatg ggaaaaatgg acgaaatgat tttagttgcc ccgcgcgatg atgtgtttaa 1872181 aaaagaaagc ttaaccttcc agggcgtgta cagtgaagat agcagagtag cagaaatcat 1872241 ggctcagatt gaagcggcct atcgtgaaat gagaagaggg gacgcagaag aagatccgcg 1872301 tttcaagcag ccgatacctt atgtcgtcat taagcgtgaa gatgaagttt ttctttacga 1872361 gcggctggct ggcggcggtg aatcacgtct gcacaacaag ctttctctcg gttttggcgg 1872421 ccatatgaac gccatcgaag gggcagcttc atttgctgaa gtcttaaagc tgaacacaga 1872481 ccgtgagctt gaggaagaac tgcaaataaa tgaagaagat aaacaggcga ttgtcacact 1872541 gggattgatc aatgatgatg aaaacagtgt tggcaaagtg catatcggta ttctttctgc 1872601 gcttcaatta aagcctggcg cacaagtgga agtgaaggag aaagaacaaa ttgcgggtaa 1872661 atggatgaaa gtttctgaat taaaacagga tgatatctac aaccgtctgg aaacatggtc 1872721 acagtttgtt gttgatattc ttgaataaaa aaacccggtt tctcgcgatg aggagccggg 1872781 tttttttatg agacgctcgt ccccgtctcg gctatgattc taggatcaca atagcgtcaa 1872841 agccggcatt tttcgctctg gcagcgaggg tgtctgcatt gtctttggat gaaaatgcgc 1872901 caatctgcac tttgtataat ccgtccttta aaaggacaat cgagtcaaaa cctttggctt 1872961 cggcattact tgcgagcgag tcggcattcg ctttgacttt aaatgcgccg atttgaacct 1873021 tatataaccc tgagctggaa gtctttttaa ggttaaaggc ttgctccagc ccgtttgcat 1873081 gtcctctcgc taagctttga ataaaactgc tcgttttcag cttatttgca tcggaaacgg 1873141 tatcaatgaa gccgttctcg gtcaagaggg caggcattgc cgactccctt aggacgtgga 1873201 agttcgctgt ttttttgccg cgatcggcaa agtcgacagc ttgtatcact tcagagtgaa 1873261 ttgtcgattg ataagtcgtc gtcggggctc ctacatctgg ataaatatag ctttcaaaac 1873321 ctgtgcctcc cccggaatta acgtgaatgg acaaaaagaa atctgctccc cagttatttg 1873381 cggcatttgt ccggtcgttt aagctgacat attggtcgct tgtccggctc agcagcagag 1873441 aaacgccttc atattcatta gttaatatcg tacgtaaggc taaagcgatt tgcagggtta 1873501 acgttttctc ctgaaggcca ttacctgttg cgcctggatc agacccgcca tggccaggat 1873561 caataaaaat tttaaccatt tttcatcacc tcattacagg atatgaaaaa acacggcttc 1873621 tgcttgtacg attatcattc aactgaaaaa tgaggaaata accctttcac atccagaaat 1873681 tatttctcgg gaaagcgcac aattcaacat gaagcgacaa cagatacggt ccgacatgaa 1873741 atctgtgcat acgccatatg tttgtatgta ctatgggttc ggttaacctg cactgattcc 1873801 tgctggtttt aagctttgcg ttcatattaa atcaagcatt taaaacgtaa attgatgagg 1873861 aaagctcctt tcattaaaga caccgcttta taaatcgaaa aaaagaaaaa cacttcaggt 1873921 atcttagggc gggtaatacg tttcgtacaa aaatcagccc gttgtatgaa aaagaaataa 1873981 tgagaaagaa gctcactata atactctgac aaaatgatta aaaacaaaat ctcatggttt 1874041 gtccacccca tgtccgtgaa tacaataaga aataaagtat ttctcgggaa agcgcaggat 1874101 tccttattgt tcccgaaaaa agcaattgtt tcgacacatg ataggcgttt gtcacaatcg 1874161 gcatccgctt gaatatcata tagagagaac agagaggtga agatgttgga gcgcgctgtg 1874221 acttataaaa acaacggaca gatcaacatt attctgaacg ggcaaaagca ggtgctgacg 1874281 aatgctgagg cagaggcgga atatcaggct gcattgcaaa aaaacgaagc aaagcacggc 1874341 attttgaagg aaatcgaaaa agagatgagc gcattagttg ggatggagga aatgaaacgc 1874401 aacatcaagg aaatatacgc ctggattttt gtgaaccaaa aacgcgcgga gcaaggcttg 1874461 aaggttggaa agcaagcgct gcacatgatg tttaaaggaa atccgggaac gggaaaaacg 1874521 acggttgcac ggctcatcgg caagctgttc tttgaaatga atgtcctgtc aaaaggccac 1874581 ttaatagaag cggagcgggc tgacctggtc ggggagtata tcggacacac cgcccaaaag 1874641 acgagagatt taatcaaaaa gtcattaggt ggcattttgt ttatagacga agcctactcg 1874701 ctggcaagag gcggcgaaaa ggactttggg aaagaagcga tcgacacact tgtaaagcat 1874761 atggaagaca aacagcatga gtttattttg atactcgccg gatattcacg ggaaatggat 1874821 cattttctct cgttaaatcc cggactccaa tcaagatttc ccatctccat tgattttccg 1874881 gattactctg tgacccagct catggagatt gcgaaacgaa tgatcgatga aagggaatac 1874941 cagctcagtc aagaagcgga atggaaattg aaagattact taatgacagt gaaaagcacg 1875001 acaagtccca ttaaattcag caatggacgt tttgtcagaa atgtgatcga aaaatcgatc 1875061 agagcacaag ccatgaggct tttaatggga gaccaatact taaaaagcga cttgatgacc 1875121 atcaaaagcc aagatctttc cattaaagaa gaagcatctg gatctgcata gacctctcag 1875181 tttttgagag gtctgttttt tgctcgtatt tccgcttttc aaagcaatcg atttgtggta 1875241 tacacatgca gggtttggta tgataatact actgcccaat atgcaaaaga aaggaacatc 1875301 catttgaacg aacaagaaac gattcaggag aaagccattt tagtcggatg tcagctgccg 1875361 catatcacgg atgagcattt tgaaaattct atggaagagc tagcatctct gacgaaaaca 1875421 gcagacggaa aagtactgac cagcgtcaca caaaaacgga acagggctga cgccgctaca 1875481 tatataggaa aagggaaggt agaagagctg aaggcactcg tggaagagct tgaagctgat 1875541 ctcctcatct ttaatgatga actgtcgcca agtcagctga agtcattggc aacagcaatt 1875601 gaagtgaaga tgattgaccg cacgcaattg atattagata tttttgcaaa gcgggcgaga 1875661 acgagagaag gcaaacttca aattgagctg gctcagctgc aatatgcact gccgcgtctg 1875721 acgggacaag ggatcaacct ttcccggcaa ggcggaggaa ttggggcaag aggtcccggg 1875781 gaaacgaaac tggaaaccga ccgccgccat atcagaaatc gcattcatga aatcaacaca 1875841 cagctttcca ctgtcattcg ccatagaagc cgataccgtg aaagaagaaa gaaaaacggt 1875901 gtgcttcaaa ttgcgcttgt cggctataca aacgcaggga aatcaacatg gttcaaccgc 1875961 ctgacgagtg ctgacagcta tgaagaagac ctcctgtttg ccacgctgga cccgatgacc 1876021 agaaaaatgg tcctgccaag cggctacagt gttcttcttt cagatacagt aggatttatt 1876081 caggatcttc cgacgacatt gattgctgca ttccgctcaa cgcttgagga agtaaaagaa 1876141 gcggatttaa ttctgcattt aattgattct tcaaatgagg attatgcggg acatgaaaaa 1876201 acagtgcttc ggctgcttga ggagcttgaa gcagatgata tcccgatgct gacggcttac 1876261 aataaacgtg atcaaaaact gcctgatttt ataccgaccg ccggaaggga tcacattatg 1876321 gtcagtgcga aatttgagga cgacgctgca gcctttaaag aagcgattca gcgctatttg 1876381 cgccaagaac tgttaacgtc ttttgaagca catgtgccgg caagtgaagg gaagctcctt 1876441 tccagaatca aatcggaaac gatggtagac cgcttctatt ttaatgaaga aaatgaacag 1876501 tatgacatat ccggctatgt ccaagaagag caaagtatca tcggtgaatt aaagaagtat 1876561 atgtaggaag gaaatataaa gacatgtttg acacattaac acacggagaa ttattgaaga 1876621 aaacggcaat ggaagtggaa gcggacattg ccggcattca taaacaaata gaagaaatca 1876681 gcgagcgaaa tgagtggaga gtgcttcaaa gctatagaaa acacaaagta agcgacactc 1876741 atttcacgcc gtctactgga tacggctatg atgatatcgg aagagacacg cttgaaagca 1876801 tatatgcgga tgtgtttggc ggagaagcgg ggcttgtaag gccgcaaatc atttcaggca 1876861 cacatgccat ctcaattgct ttgttcggtg tcctcagacc gggggacgag ctcctttata 1876921 tcacgggcaa gccgtatgat acgctagagg aaattgtggg cgtcaggggt ggagaaaacg 1876981 ctggttcgtt aaaggatttt caaatcggct ataatgcggt tgatctgacg aaagacggaa 1877041 agatagacta tgatgcagtc gccgctgcga tcaatccgaa gacaaaagta atcggcattc 1877101 agcgctcaaa aggatatgcg aatcgccctt ctttcttaat tagtgaaata aaagaaatga 1877161 tccgttttgt aaaagaaatc aatgaaaatc tgatcgtctt tgtggacaac tgttacggag 1877221 aatttgtgga agagcttgag ccttgccatg tcggagccga cctgatggcg ggatctctca 1877281 ttaaaaatcc cggcggcggc cttgcgaaaa caggcggcta cctcgtcgga aaagcgaaat 1877341 ggattgaagc ttgctcatac cgtatgacgt cacccggcat cggcagagaa gcgggggcat 1877401 ctctttactc gctccaagaa atgtaccaag gcttcttttt ggcgcctcac gttgtgtctc 1877461 aaagtttaaa gggagcggtg tttacagcga gattccttga aaaactcggc ttcacttcaa 1877521 acccgaaatg ggatgcgaaa agaacggatt taatacaatc cgttgagttt tctgacagag 1877581 aaaagatgat tgctttttgc caggctattc aatttgcatc gccaatcaat gctcatgtga 1877641 cgccttatcc agcctacatg cctggatacg aggatgatgt cattatggca gcagggacgt 1877701 ttattcaagg agcaagcatc gaattatcag ctgatggccc tatccgcccg ccgtatgtag 1877761 cgtatgttca gggaggatta acctattcgc atgtgaagaa tgccatatgc agtgcagtgg 1877821 attcattgat gcaaaagcaa ttaatttaaa ttttttaaaa atttctctgg atttgatgtt 1877881 aagaatcctt acatcgtatt gacacataat ataacatcac ctataatgaa actaagttaa 1877941 gaaaaggagg aaattgagat gagtgataat attcgccgct caatgccttt atttccaata 1878001 ggaattgtca tgcagttaac tgagttatca gcaagacaaa ttcgatatta tgaggaaaat 1878061 ggactgatat ttccagccag aagtgaagga aatagacgat tattttcatt tcatgatgta 1878121 gataaactgt tagaaatcaa gcacctgata gaacaaggtg taaacatggc aggaattaaa 1878181 cagattctgg cgaaagccga agccgagcca gaacaaaaac aaaacgagaa gacgaaaaaa 1878241 ccaatgaaac atgatctgtc cgatgacgaa ctgagacagc tcctgaaaaa cgagctcatg 1878301 caagccggcc gttttcaaag agggaataca ttccgtcaag gcgacatgtc ccgcttcttt 1878361 cattaatccg ttagcaactg ttttgctata tacatttacc ttttaagagg aggaatttta 1878421 ccaaatggca aagtacacta gagaagatat cgaaaaatta gtaaaagaag aaaacgtgaa 1878481 gtatatccgc cttcaattta ctgacattct tggaacaatc aagaatgttg agattcctgt 1878541 aagccagctt ggaaaagcgc ttgataataa agtcatgttt gacggttctt ctattgaggg 1878601 attcgttcgt atcgaagagt cagacatgta cctgtatcca gatctaaata catttgttat 1878661 cttcccatgg acagctgaaa aaggtaaagt agcacgtttc atctgtgata tttacaatcc 1878721 ggatggcaca ccttttgaag gtgacccgcg aaacaactta aaacggattc tgaaagaaat 1878781 ggaagacctc ggcttcagtg attttaacct tgggcctgag cctgaattct tcttattcaa 1878841 attggacgaa aaaggcgagc cgacgcttga actaaacgac aaaggcggat atttcgactt 1878901 agctccaact gatttaggag aaaactgccg ccgcgatatc gtacttgagc ttgaagagat 1878961 gggctttgaa atcgaagcgt ctcaccacga agtagcacct ggtcagcacg aaatcgactt 1879021 taaatatgct ggagcagtcc gctcttgtga tgacatccaa acatttaaac tagttgtcaa 1879081 aacaattgcc cgtaaacacg gcctgcatgc gacatttatg ccaaaaccat tgttcggtgt 1879141 aaacggttca ggtatgcact gcaatctatc actcttcaaa aatggtgtta acgcattctt 1879201 tgacgaaaac gcagatcttc agttaagtga aacagcgaag cacttcattg caggtatcgt 1879261 gaagcacgca acaagcttta cagcagtaac aaacccgaca gtaaactctt acaaacgtct 1879321 tgttcctggc tatgaagcac cttgttatgt agcatggagc gcgcaaaaca gaagcccgct 1879381 tatccgtatc ccggcttctc gcggcatcag cacacgtgtt gaagtacgca gtgtagaccc 1879441 agctgcaaac ccataccttg cacttagcgt attgcttgct gcaggattag acggaatcaa 1879501 aaacaaactg gaagcgccgg ctccaatcga ccgcaacatc tatgtgatga gcaaagaaga 1879561 gcgcatggaa aacggaatcg ttgaccttcc agcaacactt gcggaagcac tagaagaatt 1879621 caaatcaaac gaagtcatgg tcaaagcgct gggcgagcac ctattcgaac acttcatcga 1879681 agcaaaagaa atcgaatggg atatgttccg cacgcaagta catccttggg aacgcgaaca 1879741 gtatatgtct cagtattaat atctcaatcc cttggcacta aaagtgtcag gggatttttt 1879801 atgttaatag gtaataaatt atggagcggc actgctaaaa agcagggtca cttttagtct 1879861 atgtcactaa taattctatg tactaaattt ttaattaggg aaataattcc acgcttaagg 1879921 aagcaatacg cataaataat tcgacaaatt ctgtgataat tccattgttc aatacttcta 1879981 ccagcaataa taagatgagt aaggtagatg tttatcattg acatcataac caaatgaatc 1880041 cataattacg ttgaaatcta aatcaatttt caaaaaggag atttctatga aaaaattgac 1880101 tatcttctcc gggggattag gagcggtttt ttctgtactg gctcaactgt ttgcggttat 1880161 agatgactct tacactttgg ggaatttatg gtttttaggt gctttggcgg gaattataac 1880221 catgcttgct tcaatccaga caaataataa accagtcttc agcatattat taattgctag 1880281 ttcagtaata ggtctacttg gaactggtct tgtatacatc ataccaacac tgttcaatat 1880341 aataataatt tataaatttt caaaagtaag ccaataagcc aatgggaaaa ttaaggttct 1880401 ttttttattt aacatccctt tgacaaggtc ggtgataaat cgcagaatgt ttatgcttgc 1880461 aactaatcca ccagcggggg catcggtggg catgattatc taacgccatg tttctaggat 1880521 accggaattg aaacatttgc tgaggcattt cgtgaagctg atcaccaaat gaccatttcc 1880581 atagaggcac gtctaaagaa gctatcatag gaggacaata ctgtgtggaa agctttaagt 1880641 caattactca agaaacagaa aaatcaaagt ccaagcgatg aagattatat acagattcca 1880701 gaattagaag taaaagtttt ggggatgctt cacagtatca atatagacct ggttaatgta 1880761 atagcccaag cagaaaagtc taaggagttt ataggacaaa tcgaaggcat ctggcattct 1880821 atagcaaatc aattttattc actcgcccaa gggtttgaga atgaggatat caataagctt 1880881 tctgcggatc ttgatcatgc tgccgccact tgggaagctg ttgctaataa agcaaaagag 1880941 tttgtaacaa attcatacca agggtaaaag aaaaataagg gcctgaaagg gctcttttgc 1881001 ttatagtcat atttcccgta agtattactt tttggattta ataaatttta aagcgtgttt 1881061 gtttcactga attcatagtc aaaaggggaa tgtttttatg cttggaatca acgttgaaaa 1881121 atcaaatgaa aacttaatta tcaattggca gctatccaaa attgaaattc caatcaaaga 1881181 aatcaatgat gtatttcttg atccaaacta tgggggagag gagaaaagcg cagtaaggat 1881241 tgggtttcct tatggctcaa cagatagggt agtaattaaa acagcacgta acacttacat 1881301 tttgttcacc actaatcctg ctttaattat gagtaaaatt gtttcttaat aaacagttta 1881361 tgtccctttt aaatttatct attaatgttc tgtgtggtaa aatttagtga gatgatttaa 1881421 ggaggaggag catttatgga agaaataaaa gttagttcac atgacactag atggtattaa 1881481 gaaagcagtt tctaaatatg gtacattccc tatgtttcat catggaggat atgtcatgga 1881541 agatgctact tttcatttca aagatcctgc tagtcctcaa gaaattagcg atatagaaca 1881601 gaagctaggt gttactttcc ctaatgacta taaagagttt ttgttacagc acaatgggat 1881661 ggaaatgttt gatgggattg aaatacttag cttagaggga atcattgaat ataatgaggt 1881721 tcaagatttc ccagagggat acgttttaat tggatatcat tttgatggaa gatatgtcat 1881781 agacacaaac aaatcaaaaa atggattagg ctatatgcta tatctagact caattgatga 1881841 tattgaagat gcgattaact tagattctaa tttcgagata tggtttgata tgctagtgtc 1881901 tttaaatgga acgaaatatt gggaagtaaa tccgaatctc caagagtatt ataaactggt 1881961 ttcagaataa cacttcggca aaagaaaaaa ttatgactaa tttcaacaac caaagaaact 1882021 gcaatttgag ggaagtataa tgacaattta cgagcaaatt aaggatgctt tgaaaaataa 1882081 gatcaatgag ttggtttcac ctcaagaagt aaagaaaacc cttcaagaaa aatacggaac 1882141 taatccggat agcattattt tatcagatta ttgttataac cggtataata aggggatttc 1882201 ttttaataag cacctctttg aatatatgaa tagaagttct tacaaatact taggtgaaaa 1882261 ctctctttat acaggactta ttttcagaaa atcaaaaggg gaagataagg aagttatcgt 1882321 aggcgaatgg gtaaacggtg ttaaatcact ccgagaagct tctgttacta ataaccaaat 1882381 aaatgatcaa gccgaaatca ttagtaaaga acaacttgta aacctttata atgaatataa 1882441 ccaaatcctg agatatgaaa tgaatgtatt gaactgtaag cctacagaat tgaggcattt 1882501 aattggcaga atcggtgaat tcatttgtgc aatccaaacc aacggcactc tggcacgtca 1882561 aactaatcag catggatttg atgttgtgag tgatggcaga cggattagtg taaaaacaac 1882621 agctcaatca agtggtttta tttcgataaa taaaaataca ttttatgatt ttgatgattt 1882681 ttttgtagtt caatacgtaa atgatgattt taaagttatt ttcttcggct caaaggaaga 1882741 agtgcaaaaa ataagcagaa tttatggaag ccaatacgaa gttgaaattt cacttcttaa 1882801 aaagcttaat aaggaatacc aattaaatta aacaatcttg ttggtaacaa acatcctctt 1882861 acttattgta agaggatgtt tgtttaattc ttacatattt tatctttgca atctggctta 1882921 cgagttgcat ccacagtaaa tgatcttact tcgtctttag ttttgtcata aattccccat 1882981 attacccctc agagaaggat agggggatta ttttggagaa tcatattcca ttgcttgttc 1883041 acagtcagta atccttgagt tgttctagca agaggcaata ttgttgaata agaatagttt 1883101 taaagaggtt attgttgtct tcatattgaa ataaagatta agtatattag aggggagttg 1883161 ctttaatgca cataacaaca aaaaggttat tgatacgtga atttgaattc aaagattggc 1883221 aagcagtata tgagtataca tctgatagta atgtaatgaa gtatatacct gaaggggttt 1883281 ttactgaaga agatgcaaag gcatttgtaa ataaaaacaa aggtgataac gctgaaaaat 1883341 tccctgtcat actaagagat gaagactgtc ttataggcca tattgttttt tataagtatt 1883401 ttggtgaaca tacatatgaa attgggtggg tgtttaatcc caattatcaa aataaagggt 1883461 atgcttctga ggcagcccaa gctatcttgg aatatggatt taaagaaatg aacttacata 1883521 ggattatagc tacgtgtcaa cctgagaata ttccctcata ccgagttatg aagaagattg 1883581 gaatgagaag agaaggcttt tttaaaaaat gtattccaaa aggcaatgaa tggtgggatg 1883641 aatattatta cgctatttta gaggaagagt ggaattgaac tttattgagt gcggcaatac 1883701 aaacaaatta tcaccctcta cttagaacat attagttaaa tgaaggtgat atataaagtg 1883761 atatgacagt gattaaatgg gattcaatga gctccggtga attgttttta ggtgagttca 1883821 ctaaggatga tacctgatac gcagccatac cattcgagcg ttaatcattt tataactgat 1883881 cttttcactt ttgcccacgg gggaataaga ccctatttaa gtttgccaga cgattgtttg 1883941 atccgttgtt gatgattgtc aggatttttt gtgaaggaat atctttatat agtggttgat 1884001 tattcccttc tggtaaaaat tgatctatgt tgaattgctt aacatgtcat tgaactcaga 1884061 gaataaagtg aacctgccac agatgttcat tatcttttag ggggttccaa aaagaccgta 1884121 ttcctatcga tcgctcagag tgaaaatggt atactaaagt tacaatcaca ggaaggaatt 1884181 acaatttttt tagatctaca taaaatcatc tgattaaccg aaagtgagaa tgtgtgaatg 1884241 aatttaatag ggtatattga ggaaaggttt caaaacctcg aattaattcc tagcatctat 1884301 aatcaatggg gcacaggaat ccatttttgt cttggggaaa atatctatca actcaaagca 1884361 aatgaagaat tgaatttaaa gatgtttcgg attgtatatg aacaaacctc aatcattttt 1884421 aatgaattat ttgaacaaaa tgatgacata ttccttgtga cgaatatgta taagcacaaa 1884481 aagaaagaga aatgtataag aaaattaaag gtgtatcaac cgtttctaaa atgtaaaaat 1884541 catttgaatc aaattatggt gaagacatat ccctatcctt tcgaaatcaa taaagctgaa 1884601 gaatacgaga tgcaacaatt ttccctgtta tgcaaacctc gagacttacg tgtaactgaa 1884661 ttacttaaag cagccagtaa tgaggatttt ccacaaaaac cgaaattcgg aggttactct 1884721 attgattacc ctgatgtttt ctttgtgaac attacaaaag acattatttt ctttatctat 1884781 gatgaccgcg gatgcgaagt catagctcat gatttcaaac gaatacgtcc actttatgaa 1884841 aaatatcacg actgggtaga agagtataag tgcatgtaat acttttttta aaaacgattt 1884901 atcaggaaag gcagaattag attatgaggg ccttacatac aagatgtaaa cggttattga 1884961 aactaagatg gtattatgtg atgatgagag atctgcattt ttattagtac ttgatgaaag 1885021 attagtggat tttgattctc aaggtggaaa ccatattagt gtttatttag ttactcactt 1885081 tgagttatct gatcaatcgt ataaagatgt attaagcttt aatgatgatc ttttgggtat 1885141 ggagcataac tgttcgtatg caatggatat tctaagcgtt aaagaggaac ttgatttcga 1885201 tttcccattt aatatgcttg caataaaaag ctatgtacaa gaattaataa aaatgttagg 1885261 gattgatatc actctgcctg aaatgaaaga aagagatttt gacaaacttt ctcaaaacta 1885321 aataaaacta ctatttttaa agagaacgga gacttgcttt caatatgaat gttaaaaaag 1885381 ctgcagctgt tttttcaatc actattccaa ttatctcagc catcttaatt attaattttt 1885441 ttacaggatt tatgtcaatt ccatggcaag gaatgccggt gttttttcca ttattacttt 1885501 ctcctatagg aatcatttta gcgttcgttt caataaagac aaataaacgg tgtgctgtat 1885561 atgggattgt cttaaatgca attatgtttc catttccttt tttctggttt atcggagggg 1885621 ctttgttatt tggagtttaa aatccattag gcattacgct tatacattgg tattttcgag 1885681 cttgtcaaaa gaaggaataa aaaaacttca gaattgcttg gctttacttt atgttgaaag 1885741 gggtcgagta aggtggatag gaaaaaggat gaaatacaaa gaaaatatag ggaacaaatg 1885801 agggagaaga aagaacgaga aaaagaagat ggcagttcac atacttttga aattgttgtt 1885861 gtgctagcca ttatcatttt gatgtttttc tttaattcag ttttcaaggc tttttagata 1885921 ttgtacagat gactttcagg atgtttgaaa aaataaccct ttgagatata taccgcatga 1885981 aagtattgaa ggacttatga aaattcaaga gccagttgaa tcttaataat taatcaccaa 1886041 ataatgggga tgtaaaatga agttgtataa tgaatttatc aatatagcta aaacgtttaa 1886101 taaagagtta gacataattc cattattata tggatcttta ggtcttgaaa aggtaactgg 1886161 gttagacttt tccccagaag atattgatct ccttattcct ttaatttttt tagaggaaaa 1886221 gtgggaaaaa ctaaaaaaag tgatggaact gcatggatac aaaatggttg atttacatga 1886281 gcatgaattt aagaaaacta atacaaaaat aggcatttct tacattgagg atttaaaacc 1886341 atttgcagat gtagactata ataacctaga gatttttgaa gatggcggag cgaaatatca 1886401 tttgctaacg attgatgatt acctcaagat ttataaaaag tctttattag atggttatag 1886461 aagaaggaag aagaatcata aagaccaaag taaaattaac atattgaata aattaatacg 1886521 gaattaattt ctgtattccc ttttgtttcc agtctcaatt aaaattttta agattaaaat 1886581 aagtttgaag gaaaaatcat agtgtttaac acagccatta atcctcagac agtcaaatag 1886641 ccatttctac tccggttgaa agcttctcta tttttgcttc ttatttatct ttcctgtatt 1886701 gatatatgta tgtagggttg gacttataac ataaactatt ctggccattc cgttctttca 1886761 attcatgacc gggcttgcca tcagcataaa tctaggctaa cagtctccat acatcctgtg 1886821 atcaccttta tcaaactctt aaatgcaact taccactaac caattcttta tttcgcatag 1886881 atcatctttg tcatgtgttt acacaagaat ctgttttgga ctgagacact gaatataaca 1886941 aaacagtcaa aaatcaatat ttaattcatt ctgtttaaac tttctgaaaa agatgttgaa 1887001 aaagtcgaaa ggattttata atattaagtc aagttagttt gtttgatcaa caaactaatg 1887061 aaatgaactt tcattatcca caagataaga tcttactaat atggatggaa gggggataag 1887121 agggtcgatt taatggagct aaacaatata agaaacgaaa gaatgaggct tttatccttt 1887181 tccaggtata taaggtatga cgaaaaaaga tgaatttttt gcttgctgat caccatattt 1887241 ttttgcactg ttttgaaagc gcttttataa aagtttactg accgtaaatt cgagaaattg 1887301 ttataccgtt tcacactgtt ccatattaaa ggatcgaaaa ggggagaaat catgctcagt 1887361 gaaaatgtaa agaagattag catggttgaa aaagttggat atgcgtctgg agattttgct 1887421 tgtaatttaa tttatgcaac agtgtctacg tatcttttgt tcttctatac agatgttttt 1887481 ggtttatcgg cagcagcagc cggtactatg tttttagtgg ttagaataat cgacgctctc 1887541 gctgatcctt ttatcggaac aatagttgac agaacgaaca gcagatttgg acgctttaga 1887601 ccgtatcttt tattcggagc ttttccattt gtcatactgg caatactctg ttttacaaca 1887661 ccagactttt cggatatggg gaaattaata tatgcctata taacctatgt tggcttgtcg 1887721 cttacataca caacgataaa cgttccatat ggcgcgttaa cttctgcaat gactagaaat 1887781 aatcaagaag ttgttagtat aacttctgtt cgcatgttat ttgcgaatct tgggggactt 1887841 gtcgttgcat tttttgttcc cttactggct gcttatttaa gcgatacttc cggcaacgag 1887901 tctcttggct ggcaactaac catgggtatt ttgggaatga taggcgggtg ccttttaatc 1887961 ttttgtttta aaagcacaaa agagcgggtc actcttcaaa aatccgaaga gaaaattaaa 1888021 tttacggata tatttgagca gtttcgtgtt aatcgtccac ttgttgtatt aagtattttc 1888081 tttattatta tttttggagt gaattccatc agtaattcgg ttggcattta ctacgtaacg 1888141 tataacttag aaagagagga tttggtgaag tggtacggtt tgataggaag tttacccgct 1888201 ttggtcattt taccgtttat tccaaggctt catcaatttt tggggaaaaa gaaattacta 1888261 aactatgcat tattactgaa tattataggc ctcttagctt tactgtttgt tccgccaagt 1888321 aatgtttacc tcatacttgt ctgtcgatta atcgctgctg ctggaagtct cactgccggg 1888381 ggatatatgt gggcgcttat tcctgaaaca attgaatatg gagagtacag gactgggaaa 1888441 agaatgggtg ggctcattta cgctataatc ggatttttct ttaagtttgg tatggcctta 1888501 ggaggagttg ttccgggtct ggttcttgat aagtttggat atgtagcaaa tcaggcacaa 1888561 accccggcgg ccttaatggg gattttaatt acaacaacca ttattcccgt gttcttgctt 1888621 gttctagctt taattgatat taatttctat aacttagatg agaaaaaata taaaaacatg 1888681 gttcgagaat tagagaatag agacaaagtt tatttggatc atattgatga tttcaaggct 1888741 taaaaaagaa aataaactga ggaggagtcc caaatgaaga ttaccaatcc cgtacttaaa 1888801 ggattcaatc ccgatccaag tatttgtaga gcaggagagg attattatat cgctgtatct 1888861 acatttgagt ggtttccggg agtccagata caccactcaa aagatttagt aaattggcac 1888921 ttagttgcac atccattaca gagagtttca caattagaca tgaaaggaaa cccaaattca 1888981 ggtggagttt gggcaccatg tttaagctat agtgatggga agttttggct gatctatacg 1889041 gatgttaagg tagtagatgg cgcatggaaa gattgtcaca attatttagt tacttgtgaa 1889101 acgattaatg gtgattggag tgagccgatt aaattaaata gctcggggtt tgatgcttct 1889161 ttgttccatg atacggatgg aaaaaagtat ttattaaata tgttatggga tcaccgtatt 1889221 gatcggcact catttggagg aattgttata caggaatatt ctgataaaga gcaaaaatta 1889281 atcggtaaac caaaagttat atttgaagga actgatagaa aactgacaga agctccgcat 1889341 ctttatcata tcgggaacta ttattattta ttaactgcag aaggaggaac acggtacgaa 1889401 catgctgcta caattgctcg ttctgcaaat attgaggggc catatgaagt tcatcccgat 1889461 aatccaattt taacgtcatg gcatgaccca ggaaatccat tgcaaaaatg tggtcatgca 1889521 tccattgttc aaacacatac agatgagtgg tatttagctc atttaacggg acgtcctatt 1889581 catcctgacg atgattcaat ttttcagcag agaggatact gtcctttggg cagagaaaca 1889641 gctattcaaa aactttactg gaaagatgaa tggccctatg tagtaggtgg aaaagaagga 1889701 agcttggagg tagatgcacc ttctataccc gaaacaatat ttgaagcaac gtacccggaa 1889761 gttgatgaat ttgaggattc aacattaaat ataaattttc aaactttaag gattccattc 1889821 acgaatgaat taggttcatt gactcaagcg ccaaatcatt tacgattatt cggtcatgaa 1889881 tcattgacct cgacatttac tcaggcattt gtagccagac gctggcaaag tctccatttt 1889941 gaagccgaaa ctgctgttga gttttatccg gaaaattttc aacaagccgc tgggttggtg 1890001 aattactaca atacagagaa ctggacggct cttcaagtca cgcatgatga agaacttggg 1890061 cgcattcttg aattaacaat atgtgacaac ttttcttttt cacagccatt aaataataaa 1890121 attgttattc ctcgtgaagt aaagtatgta tatttaagag taaatattga aaaggacaaa 1890181 tattattatt tctattcttt taacaaagaa gattggcaca aaattgacat tgcactggaa 1890241 tcgaaaaaat tatcagatga ttatatccgt gggggaggat tcttcacagg ggcctttgta 1890301 gggatgcaat gccaagatac cagtggtaat catattccgg ccgactttag atattttcgt 1890361 tataaagaaa aataatttgc acatgaaaaa ggagatttct attttagaac tcctttttca 1890421 tatgagaagg tgccatgtca ctattgcttc agaaatactc ctagaataaa aaaactcatc 1890481 tttaaagatg agctgtccat tccataaaaa attacattgt aatcatgtcc agaaaatgat 1890541 caatcacaat ggaggacatt cctaatgccg gtgcattctg tcctaaggaa gatggcaata 1890601 attcatagct attgcctaat tgggaataaa cccttgatga tacttcactt ctcattgaat 1890661 ttaaaaccat aggatgcgat tcaattatgc tatttcttaa aattacggct tgtgggttga 1890721 aagtatttag aatattggta aggcctattc ctaaatagaa tccaaaattt tgtaatgcat 1890781 ttaaggttcc gatatcattc agatgggcga ggtttatgat atcttgatag gacagttttt 1890841 tctctttggt ctgaagagat tttaataaag ccttctctga agcatacaat tcccagcatc 1890901 ctcggtttcc gcaactgcat ttaggaccat taaagtctat tgtcatatgt cccatttctc 1890961 cagagaagcc gcttactcct ctatataaat gattgttgat aataacaccg atccctattc 1891021 ctgtgctgat acttacgtaa ataatgttat cgtgattttt tgcagctcca aatacttttt 1891081 ctccatatgc gccagcattt gcctcatttt caataaaaac aggcacattg tacttctctt 1891141 gtatcgaaga ttttaagtca atatctctcc agttggagtt cggagtgaaa acaatttttt 1891201 gatctttatc aatgagtcca ggcacgcaaa tacctatacc aataagcccg tacggagatt 1891261 ggggcatttg cgtaataaag tgatgaatca tatcaatcaa aatgtctttc gttatttctg 1891321 gagaattgga ttccaaatgg cggtattgat caagaacgat tgttccttca aggtctgtta 1891381 aaatgccatt aatataatcc acaccaacat ctattccaac ggagtatcct gcctttttat 1891441 taaaaacaag catgacaggt cttcttccgc cacttgattg tccttgacct atttcaaata 1891501 ccatactttc tttcattaac gtgtttacct gtgatgagac agttgattta tttaatccag 1891561 tcatttcaga taattttgct cttgaaatag gtgaattttt aaggatttct tttaataata 1891621 acttttgatt tacttttttg acaaaggttt gatcagcgat atccacttca tccactccat 1891681 ttgtttaatc tttaaattaa gtatcaacat agtacatagc gaatcttccc tttattatat 1891741 ctaatgtgtt cataaaaaac taaaaaaaat attgaaaata ctgacgaggt tatataagat 1891801 gaaaataagt tagtttgttt aaacaacaaa ctaataggtg atgtacttac tatatgaaat 1891861 aaaatgcatc tgtatttgaa tgaatttatt tttaaggggg aaatcacatg gctcaatctc 1891921 attccagttc aatcaactat tttggaagcg caaacaaagt ggtttacgaa gggaaagatt 1891981 cgactaatcc tttagcattt aaatattata atcctcaaga agtaatcggc ggaaaaacgc 1892041 tgaaagagca tttgcgattt tctattgcct attggcatac atttactgct gatggtacag 1892101 acgtttttgg agcagctacg atgcaaagac catgggatca ctataaaggc atggatctag 1892161 cgaagatgag agtagaagca gcatttgaga tgtttgaaaa actagatgca ccattctttg 1892221 cttttcatga ccgggatatt gcaccagaag gcagtacgct aaaagagaca aaccaaaatt 1892281 tagatatgat catgggcatg attaaagatt acatgagaaa tagcggcgtt aagctattat 1892341 ggaatacagc aaacatgttt acgaatcccc gtttcgtcca tggtgccgcg acttcttgca 1892401 atgcagatgt gtttgcgtat gctgcagcac aagtgaaaaa agggttagaa acagcaaaag 1892461 agcttggcgc tgagaactat gtattttggg gcggccgtga aggatatgaa acattgttaa 1892521 ataccgattt aaaatttgag cttgataatt tggctagatt tatgcatatg gcagtggatt 1892581 atgcgaagga aatcgggtac acagggcagt ttttgattga gccaaaacca aaagagccga 1892641 ccacccatca atacgataca gatgcagcaa caaccattgc ctttttgaag caatatggct 1892701 tagacaatca ttttaaatta aatcttgaag ccaatcatgc cacattagcc gggcatacat 1892761 tcgaacatga attacgcatg gcaagagtac atggtctgct tggctctgtt gacgcaaacc 1892821 agggtcatcc tcttttaggc tgggacacgg atgaatttcc gacggattta tattctacga 1892881 cattagcaat gtacgaaatc ctgcaaaatg gcggccttgg aagcggcgga ttaaactttg 1892941 acgcgaaggt cagaagatct tctttcgagc ctgatgatct aatatatgcc catattgcag 1893001 ggatggatgc atttgcaaga ggattgaaag ttgcccacaa attaatcgaa gatcgtgtgt 1893061 ttgaagatgt gattcaacat cgttaccgca gctttactga agggattggt cttgaaatta 1893121 tagaaggaag agctaatttc cacacacttg agcaatatgc gctaaatcat aaatcaatta 1893181 aaaacgaatc tggaagacag gagaaattaa aagcgatatt gaaccaatac attttagaag 1893241 tataacagga taagctccag atcctgctat caataccaag tcactgaatt acccgtcatg 1893301 attcctttcc tattgcttgt tgttatgacg ggtaacttct ataattagga tttatttaga 1893361 gtgaatggtt ttttaaaagg gcaaggagtg aaaaaatgaa gtatgtcatt ggaatagatc 1893421 ttggaacgag tgctgttaaa accattttag ttaaccaaaa cggcaaggtt tgtgcagaaa 1893481 cgtccaaaag gtatccgctc atccaagaga aggcgggata tagtgagcaa aatcctgaag 1893541 actgggttca gcaaacaatt gaagcattgg ctgaattggt ttctatatcc aatgttcaag 1893601 ccaaggatat tgacgggata agctattcgg gacaaatgca tggattagta ctgcttgacc 1893661 aagatcgtca ggtgttacgt aatgcaattc tttggaatga taccagaaca acgcctcaat 1893721 gtataaggat gaccgagaaa tttggcgatc atcttcttga catcacaaaa aaccgtgttt 1893781 tagaagggtt tacattacct aaaatgttat gggtaaagga acatgaacct gaacttttta 1893841 aaaaaactgc tgtgtttttg cttccgaaag actacgtgcg attccgtatg accggtgtca 1893901 ttcacaccga atactccgat gcagcaggaa ctttactttt acatattact cgcaaggagt 1893961 ggagcaatga tatttgcaat caaattggta tttctgcaga tatttgtcct ccgcttgttg 1894021 aatctcatga ttgtgtagga tcgctgcttc cgcacgttgc cgcgaagacc gggctattag 1894081 aaaaaacaaa agtgtacgct gggggagcag ataatgcttg cggcgctatt ggagcaggta 1894141 tcctttcttc cggaaaaaca ttatgcagta ttgggacgtc aggggtcata ctttcctacg 1894201 aagaagaaaa agaaagagac tttaaaggga aagtccactt ttttaatcat ggaaaaaagg 1894261 attcttttta tacgatgggc gtcacgctcg ctgcaggata cagcttggac tggtttaaaa 1894321 gaacgtttgc accaaacgaa tcgtttgagc aattattgca gggggtggaa gctattccga 1894381 taggagccaa tggactgcta tacactcctt atttggttgg tgaaagaacg ccgcatgctg 1894441 attcttctat tcggggaagc ttgatcggaa tggatggagc ccataataga aagcattttt 1894501 tgagggcaat aatggaaggt atcacattct ctttacatga atcaattgag ctattccgcg 1894561 aagcgggaaa atcagttcat actgttgttt ctattggtgg gggagctaaa aatgatacgt 1894621 ggctgcaaat gcaagctgat attttcaata cgagggtaat taagttagaa aatgaacaag 1894681 ggccagctat gggggctgca atgctggctg cctttggaag cggttggttt gaatcacttg 1894741 aagaatgtgc agagcagttc attcgtgagg ctgctgcatt ttatccaaag gcgcaaaatg 1894801 ttcaaaaata taaaacacta tttgatttgt ataagaacat ttacactcac acaaaggatc 1894861 tcaatacagc tttgaagagc tttcgaaaaa actaatgatg ttattgtctg gagatcaacc 1894921 gaagaacaat taatgatcaa tcatcatcaa aggcctttga taacatggct gccttctttt 1894981 gaaaagatgg tgagaataag gtatcgcaac ctttaaacag tattggagta tccagcagac 1895041 aaaacgaacg agtggaaccg tattttgtca gcgaacactt caagaagtgg ggaagcttag 1895101 gaatgccaat gggtaagatg tatgaaaccg cgctaacgac ggtagaggga tctcttgatt 1895161 tatgaagaaa taggaaggat gttaacacac aaataacccc tcacattgac gtgaaggggt 1895221 gttttttatt gttactatac agcggaaatt ttacaggcta gttgcatgat tttagcttgt 1895281 taagcagaat ggaactagac tctccatcat ctctttctca ttctttggaa actgcattct 1895341 gctaggtttg ctgctttttt taacaaacag tgtttttcta tttcacacag ccattaaatc 1895401 ctctgttcgt cacataaccg ctcttactcc aaattgacag tttatctgat tttgcttctt 1895461 gctcatctag tctgaattgg tctatgtatt ttgtgttagg ctcatataca tatgctactc 1895521 tggccaatcc ctctttcaat aatgtctctt gaacagattt gccgtcaaca taaacgtatg 1895581 ctaacagtct tccatactta tctctgcgat cgcctttatc aaattccagc tgtagcttac 1895641 cgctgttgac caattcttta tttcgtttcg acgcatcctc accgtatggt tgaacacaag 1895701 aatttggttt cttcgtctca ggtgtatcaa cgagcaagta gcgaactgtg tctttctttc 1895761 cgttgtaaat aaccttaatc gtatctccat ctattgctct atctaatgta acattgacca 1895821 atttcttctg attttttgaa tgaggcgtgc cagccttttg ttctgtctga ttatattcat 1895881 tagagtgagt atcttgagag acttgctccg tcccattaga atctgaatgg tttttggctg 1895941 cgtgatttga tccgcaagct gccaaagtaa tacttaaaac gattgcgatc atactgatca 1896001 aaatcttctt catattgatt ccctctttat cattttctct tttcgcgatt aaacatcatc 1896061 attataacga tatggacatt ttttgtgaat ggaaaacttc aagggaactt ataacactcc 1896121 aaattgccaa tagttaactt cacaacgaga tgatcaaaac atcaccatca catagcggaa 1896181 ataaataatc ctgaaaataa tattgactga aaatgctttt agaattatga taatatgaga 1896241 aatgacaata atgtgacaaa gacattacta caacataaca actaatagct taggtttatt 1896301 ctattggtta aaaatgtaaa cggttacaaa tccagaggcg aaaatctaag atagagatga 1896361 ctttagtttt gactcaatat ccacactgaa agagcttatt aagtattctt aaaggcaggg 1896421 gaaatggata tgaatgaaca tcgaaatcga aggttgaaat taataatgat ttcagcaact 1896481 tttggagggc ttctctttgg atatgacacc ggagttataa atggagcttt accttttatg 1896541 gcaaggccag atcagcttga tttaacacct gttacagaag ggcttgttac gagtattctt 1896601 ttattaggtg ccgcgtttgg agcgttgtta tgcggaagat tggctgatcg atatggccgc 1896661 cgtaaaatga tccttaatct ttccttttta tttttcctgg catcactggg aacagcgtta 1896721 gcacctaatg ttttcatcat ggcggtcttt cgttttttac tggggctggc tgttggagga 1896781 gcctcggcga tggtgccggc ctttttagca gaaatggcac cgcatgaaaa gagagggcgt 1896841 atggtaaccc aaaatgaact aatgattgtt ggcgggcaat ttttagcata tgtttttaat 1896901 gcgatcctcg gtgtaacaat ggcaaatacg ggacatgttt ggagatacat gctagtcatt 1896961 tgtgctgtac cggctatcat gttatttgcc agtatgctta aggtaccaga aagcccccga 1897021 tggctaatct ccaaaggcaa aaacagtgag gcgctgcgag ttcttaaaca aattcgagaa 1897081 gataaacgtg cagaagctga atgtagagaa attcaagaag cggtagaaaa agatacagca 1897141 ctagaaaagg catcactcaa ggacttttct acaccatggc tgcgccgtct tttatggatt 1897201 ggaatcggtg ttgccatcgt gaatcaaatt acaggtgtga actcgattat gtattatggc 1897261 acacaaatcc ttaaagaatc tggttttggt acaaaagcgg ctttaatcgc taatattgga 1897321 aatgggctga tatcagttat tgcagttata tttgggattt ggctggtcgg aaaagtgaga 1897381 cggcgtccaa tattattgat tggtttggca gggacgacta cagcgctcct attgattgcg 1897441 attttctcaa ttgtgcttga tggatctatg gcacttcctt atgtagtgct ttctttgacc 1897501 gttttatttc ttgcctttat gcaagggtgt gtaggacctg tgacttggct tgtcatagcg 1897561 gaaatattcc ctcaaaggtt aagaggactt ggttctggga taagtgtttt tttcctttgg 1897621 atattaaact ttgtgatcgg ttttgctttc ccgatcttgc ttagctctgt aggtttgtct 1897681 tttacattct ttatatttgt ggctttaggt gtattggcaa tcggttttgt gtacaaattc 1897741 atgccggaaa caaaagggcg tacacttgaa gaattagaag agcattttcg ttctcgacac 1897801 gatcataata ctcctgaaca atcagttatt gaggtataaa tatgttgaaa atctctcttc 1897861 ttataggagg gattttttta gtttcagaaa aaacaaaatc cctctggtag agggattttg 1897921 attcagcatt ttaagatgtt ctacacgtat aatactggag ttgatacttt aaaaatctcg 1897981 ccatctctta tataaaaacg agggatgcgg cggcttaatg tagacacgac ttcatagtta 1898041 atcgtattga gcatttcagc cacttcatca acggaaatct cggctccttt ttgcttaccg 1898101 taaatcacga cttcatctcc ttgtttacct tcaccgtttt ctcctaaact gaccatgatc 1898161 atatccattg ttactcttcc cgccactggc actcgttttc cgcgatgaag aacaaacccg 1898221 cgattggaaa gggcacgaga atagccgtca gcatagccaa tcgggagtgt agcaattact 1898281 tcattaggtt ctgcgatgta tgtagcacca tagctaacgg ttcggggttc tgtccgcatg 1898341 gttttcacat aagcgatgcg tgcctttaaa cttaacgcag gttcaagctt aacgagattt 1898401 agttgtttaa tataggctga aggatataaa ccatataagc cgatacctaa acggatcata 1898461 tcagcgctaa attccggaaa tgcgatagct gcagccgtgt tgcacatatg cacggtgggc 1898521 agctcaatcc cctgtttttt taaaaagctg agaaaactga tgaatttttc atgctgcagc 1898581 tttgtgagtg ttgtgtccgg ttcatcagct gtcgaaaaat gtgtgaaaat ccctgtccat 1898641 ctgaggaatt tacttgcctt taaggctttc actacctcta aaagttcttc ctttgtgcgt 1898701 acacctaatc gtcccatgcc ggtatccacg ttaatatgaa tggccagccg gttagcactc 1898761 gcttcttttt ccaatatctc gtttgcttct ttcatccaat caacctgaaa tgctgataat 1898821 gttatattcc aagctgctga cttctttaca caactaaggg atgtaaaacc aagcacaagg 1898881 ataggtgctg taatcccagc tttacgtaaa acgattcctt cctccacact ggcaacagcg 1898941 agctcactcg ccccgtgttc cagtgcatgg cgtgccactt ctatagaccc gtggccataa 1899001 ccgttcgctt ttacaacagc cataattttg ctcttatgtg gaatatgacg gcggatcgct 1899061 cgcaaattct ttttaacggc atcaagattg acttcgatcc aaacttctcg gcaaagcttt 1899121 atcatcaacg cttccttcct tcttatggat tataaatacc acctattgcc gcaagaataa 1899181 atgttaattg ttggatgatt cgatcttatt ttattcaact ttatttgaaa tcattcaaca 1899241 gcaaatccat gtgatacgag aaggtgccta tcaatgttcg aataatagca agtacgggat 1899301 acatgaggct tgtaagtggg gtgttaatgg atgcggcgac cgaggattac aaaaatgatt 1899361 atttgttttg ggacattttt ttctaagggt agatgataac gagaaatcta atcaggaaat 1899421 acttaccgtt gttatgaaca ttgaagaacc ttttaaatga gaagggctga ggaaattctg 1899481 taaaagataa tcggttgaaa aggcagtcga ttccttgttc cataaaccta acatcagagt 1899541 atataattat actcgtattc acaaaaatcg tttaagtaag gggtatacat gaatagggga 1899601 gttagttttc aaataccgaa tgaatatgga aattttctat ggagaatact gcagccggta 1899661 gaaatagcta attataggtg gcaaacgagt ggggaatctt attttgttgt agaaggagag 1899721 ctcgatgatg aggagctttt tcatgactac gaaattgttg agggggcagt ttttgagcaa 1899781 caattaaaaa cgaatcagta ctataccatt ttcgttgaac tgaaagcatt tccatatgga 1899841 aaaatggtta atcaagtcaa tacatatgaa gagtttgctg acagtgattg cgaacttgtc 1899901 cttttgatag cagataatag ctacgtttcg atttactgta aaaacaaaaa tatcattgaa 1899961 aaactttact tcaatgcttt acagcatgat tttgaagacg ttcaatttat aactgatgaa 1900021 aatgacacaa gaacaagcct tactgtatga tactcaataa aaattaaagg agctagtaca 1900081 tgacaatgca aattaaaatc aagtatctag atgaaacaca aacaagaatc agcaaaattg 1900141 agcagggaga ctggattgat cttcgggcag ctgaagatgt aacaatcaaa aaagatgaat 1900201 ttaagcttgt cccattaggt gttgcaatgg agctgcctga aggttacgaa gcacatgtcg 1900261 tccctcgttc aagtacatat aagaactttg gcgttattca aacaaattca atgggtgtta 1900321 tcgatgagtc atataaggga gacaacgatt tctggttctt tcctgcttat gcattgcgtg 1900381 atactgaaat taagaagggt gatcgtatct gccagtttag aatcatgaag aaaatgccgg 1900441 cggttgaatt ggttgaagtc gagcatttgg gaaacgagga tagaggagga ctcggttcaa 1900501 caggtacgaa gtaaacaaaa taaatccttg gctgtcttca tgctgtgtga ttgatcaatg 1900561 gaggtttcag ccaaggtaca tataaatatt atgtataaaa tgaatatttt aatacgaagg 1900621 atttaattaa aaacaaagtt taaaaaggga agttttgaaa aagtgaaata gtaataacta 1900681 aagtcgataa agaacctaaa gatgtcaaag aaacaatttt tctggtgctt tgcttttttg 1900741 aaggtttact tagctcgtgg ataactgccc cccataaaag catggatgct aaaattataa 1900801 tacttatata cataaagatg ctccttttat tatatttaca gtttttacat ttttatcgat 1900861 tttaccacat ttaggattga gttgtcgatg aaacaagcat ctctataaag aaatactttt 1900921 atctaaattt ttataaatag gggaaggcaa ctaaaaacta gtaatgccac taataataag 1900981 ccaagttaaa tgacttgtgt tcattaataa ttgaatttta cagcagccat gagcacaaaa 1901041 aaatctgagt tcgtcgataa atatcataaa aaagcccccg gtatgtcgcc agggaataaa 1901101 tagacgttta agagatttag tgatgttttt tatatgattc gacaaaatca taataatgat 1901161 catcgtcatc ataatacttt ttttcgtaat gataatcgtg atcatcgtaa tactttttat 1901221 catggtcatc atactttttg tcgtaatcat aatgtttttt atcatgatca taatacttgt 1901281 cgcaatcata atgcttctta tcattgtcgt aatacttttt gtaatatgtt tttttccaag 1901341 tataatactc ttctttatat tttttataat aacccaatta aattcctcct ttatgttatt 1901401 cgaatttaat ttatgaagtt taaatgatat ggtatggtca aatgaaataa gaatagtaaa 1901461 aagaggctgt ttaaaacact ttctgaaaaa caaaacggat agctgtttat gaaaataaga 1901521 gcgagagaga gcactcaatc actgtaaaat aatagtaaag tgtatagaga gattagtata 1901581 cgtaaaaagg gactttctca ttgaagaata tttgaacgtt atggttaaga ttcaagagct 1901641 ctatgatgtg atttttcaca ctgcttttga aggatttaga gttagacatc aaaaacaaac 1901701 agcaaaaccg gctagaaaca gatcatataa ggaatgaacc gctgccaaat atcataaaaa 1901761 agttgttaat gatcaaatga atgaaattag agagaattta ttttaaagaa agcccaattg 1901821 cacatggaca aatgacaatt gatattgagg taaaatacaa tgcattaaat cagaaaaagc 1901881 tattggagga tttaatgtgt ttagacaatt tccaatttgg tatacacaaa cacctgacta 1901941 tttgaatttt tatgtaccgc aatatcaaac catttcgtat aatcctcaac aatgttatca 1902001 acggtgtatg taccaaactg gcggtaacta tgagctatgt gacagactat gttatggaga 1902061 aatacaggtg taaaagaggg ggattaactc ctctttaaac acacagtgag tggaataaga 1902121 tcctcacttt atctgcaagt gcttagtatt tgcgataata ttgcattcgt aataaattat 1902181 gcttagcaac tgaaaatgaa agaaggatat gaatagtcat gacgcaattc gataaacaat 1902241 acaattcaat tataaaggat attatcaata atggaatctc agacgaagag tttgatgtaa 1902301 gaaccaagtg ggactcagat ggaacaccgg cacatactct aagtgtaatc agtaagcaaa 1902361 tgagattcga caactcagag gttccgattt taacgacaaa aaaggttgcc tggaaaacag 1902421 ccattaaaga gttgctctgg atttggcagc tgaaatctaa tgatgttaat gatttaaaca 1902481 tgatgggcgt ccatatttgg gatcagtgga aacaagaaga cggaaccatc ggacatgcat 1902541 atggatttca gctggggaag aaaaacagaa gtctaaatgg agaaaaagtg gatcaggtag 1902601 actatcttct tcatcaattg aagaacaatc catcttcacg cagacacatt acaatgctgt 1902661 ggaatcctga tgaattagac gcaatggcct taacgccatg tgtatacgag acacaatggt 1902721 acgttaaaca tgggaaactc caccttgagg taagagcacg gagcaatgat atggcattgg 1902781 gaaatccatt caatgtattc cagtataatg tgttgcagcg catgattgct caagtgactg 1902841 gttatgagct tggtgaatat atctttaaca ttggggattg ccatgtgtac acacgtcata 1902901 tagacaattt gaaaattcaa atggaaagag aacagtttga agcacctgaa ctatggatca 1902961 atcctgaagt gaaagatttt tatgacttta ccattgatga tttcaagtta atcaactata 1903021 aacatgggga caagctttta tttgaggtag cggtttaatg ctgccttttt attgtgcagt 1903081 gaatagatag caggtatcct aatttcatta agcaatctgg aagatgaata aaaattgaag 1903141 gacaaacacg tataatacat aaaaaagatt aactctacag ttaatctttt ttattcagaa 1903201 gaaaatatcc taactttgaa actaaataca aagtaaaagc aatcattaca gttctagata 1903261 ttacaattcc atgaatagct agatcatatc cagcaggtat caacgcattt gtattacaca 1903321 taaaatatat agatattaga agtgctacaa taactaaaat cattccaaaa agacttgttt 1903381 tttcatattt cataccaatt tccaccctta ttaaagttag gtttaaacaa aagagctgaa 1903441 gaaacgaact atgaccagta tgctccaagg aaaaccgcca gacaatgctg gcggcttttt 1903501 gctgcttcgt ttatttatta acagagatcg taacgttatt tcctgcaact gaaacctttg 1903561 cgaaatcctg tgtatctacc acaggagtga cggctttatt gtcgatagtg atgttgttaa 1903621 aagaggtcga aaaggttgct ttgatcgcat cacgctggct ttcatacgaa acagccgcgg 1903681 tagcaagtgt tttccatttt gaaatcgtgc cgatgttggt tccttgaatt tctgtgataa 1903741 tccgtccggt gtagccgtca ttgttcgttc cccaaagggt catgcgcgta ttgccgctta 1903801 aatttttata gattgtcatt tggactgtgc ttccagggcg gaagccttta ttgtatgtga 1903861 atttgtcttt tccttcgatg tacgtttctt catttttgga cccaaccttc atgaggggct 1903921 tccagacgtt gtattgtttg ctgtactgaa gcccgatatc ggcttcagtt ccgcttgttg 1903981 ccctaaagcc agaataaata tagggagtag agaccgagtc gttgtttttg acagtttcag 1904041 gaagcacgat tttagctgta aaaacggcgc ccgtactgtt caggtagaca cggccgccga 1904101 ttccgttagg cagctcggat gctgcttttg cgacttgagc gtctgccgcg ggtaaacctg 1904161 gtatacctga tgaaagggtt ccgaaaagaa ctgctgttcc tactgcacct gcaatcaata 1904221 cttttttcac caaaattccc ccttttgata gtggtttcgc catttattat accttatttt 1904281 ggaactggat ttacgtatat aaatcgacaa aatatttcat tttgaatgat gtaaggtcga 1904341 aacgcttcgc caatctgaaa gctatatacc tttatcagag gaaagaatga gatcacattc 1904401 gttttaaccg atttgaaatt ttcctcaaaa taaaagtaca aatgcttaaa gaaacgatta 1904461 ttaaaagaat gcccgctatc gtttccaagc ctgtaaaaaa gaggtgacgt ttcatcaatg 1904521 tctgtccttg taaaatgata aaagcacaga taccgactaa gaaaagaaaa caaatactta 1904581 ggattgctaa cgctttacgt gagtatgttt tcatttcatc tttaaaatac agcaatacga 1904641 aaataaagca gataacattg gctattgttc taatcacctc aaagcttttc atgacaactg 1904701 atataaatag acaaagtaaa atgagataaa atacgatgtt tctatacaaa aaacctctcc 1904761 ttttatgtag gatcctcaaa gagtttataa aagtttcttt gtaactgcaa taaattgaat 1904821 gcgctcactt atgaactaac taaactatgt actaaatatt cactattctt tttcagattc 1904881 agtcaccaag gttttcatag aaagggaagc ttcagaaata tacatatagt gcacaaacaa 1904941 aaaagacccg gcaatagccg ggggaaagta aaaacgagga gatgttaatg gcgtttagta 1905001 gtgtttttta tgctttttat actctacaac ataatcatag tcttttttat cgtgatcata 1905061 atatttttta tcatagtcat catatttttt gtcgtaatca cagtcataat cttttttatc 1905121 atattcgtaa tacttcttat aatacgtttt tttgaccgta taatactctt ctttgtattt 1905181 tttgtaataa cccatatata ctcctccttt atttttacta cgctttatta tacggcgagt 1905241 agattttgcg gcttggacag ttaaaatcat agaaggaaaa aagggctgtc caaatgatag 1905301 aaaaagacag atgacacaaa aacaaatcaa aataaagagc cgatttttca tcggcccaaa 1905361 cgatttatcc tacatttgtt tgtcttcttt gttttctgag tcattttttc tgatatcctg 1905421 agtcagtccg cttgttgctt gtttaaattc tgataaggct tttcctgctg cacggccaag 1905481 cgccggcagt ttatcaggcc caaatactaa aaaacccaca aacaaaataa cgagtatttt 1905541 tgtgaagctt aattccatat ccttttcccc ctgattgaag tacaaccttt taaacaaatt 1905601 ataagagata gcagtacaaa tgggaatgca tttattttga acattttaaa accagcacaa 1905661 agacggattc ataaaacggc tgctgctgaa tataatgtcc aatgccacct gcctaagaag 1905721 caggaggcag gctggatcaa ttatgtagct ctgccggaaa tgatacaaac gtagcggcta 1905781 tcattgacat agaggagtgg tgtagctgat gagattcact aaggtagttg gatttttgtc 1905841 tgttttaggg ttggctgcgg tttttccatt aacggcacaa gcagaaaaag ccggaactgc 1905901 gggggctgga gagtgggata agttggggac ttacacatat acttactcaa gtccgacggt 1905961 atactcgacc ggaggagatt ttagagtgtg cctttcagga agcactcctt tttctgtttc 1906021 actgcactta tatgaggatg atcccggtga caatcctgat gattatgtag gggcaaacta 1906081 tttttcaccc ggagaatgcc acacctttgg cagtattgga aaatttgtag atgggagcaa 1906141 taacaaggcc gagttctttg ttaccgatta ctctggtaaa tctaaaactg ttacgtttta 1906201 tgattgatgg actcaaattg tgaagtataa cccttggaaa aaaacaaaaa agagagatac 1906261 ctctctcttt tttattcttc gacagcctta cgaagccgtt catttacaat gccagtccag 1906321 ccgccatcca tcttaccgcg aacgacggag cttttctcgt ttgctttgcc gatcacttca 1906381 ttcggctctt tccagccgct gtgaataagg gtaaaccctg tcttttcccc caagtcttct 1906441 aattgaaagg taacgaccca tccttctgta tcccattcaa aagaaagttc agttggagct 1906501 tgaacagcca aaactttaca aggggacggc ccaaacggcg attgtaagtg aaattcttgt 1906561 ccttctttga gctgaaagtc attgggcata aaccacttgg caatgccttc tgaagtagag 1906621 actgtctccc agactttctg aatgggagcc tccagagtaa tgctttttgt aatatccggt 1906681 aatgcatttt cgttgttttg agccatttcg tttacctctt gacatatgat gttttttcaa 1906741 ttcaatcata taataactaa taagatcatg tccatagcgt gcattattta tgctagagct 1906801 gctgttgaac agcgtgtcag tcgccagtct gatctgtgaa tgggagaatt ctgcatgcgc 1906861 gaaaaagaga gagaggtgta tgttgtcatt tcgttcattc ttgtttgcag ccgcaactgt 1906921 tatgtttgaa ctgggattcc tgttcagcca atttattttg cgatttttgt tttaatagta 1906981 aatgagccat tttctaaaac aggaggtttt ttatgcttgg aaaaatcaaa gcagccattg 1907041 ataatagtcc agggaagccg gccagaattt tagttagtga aaaagcgttt cagcaattag 1907101 aggaagaaat gcgctttgtt tacgtttcca aaccgaaaac gataatgggg attcctgtgg 1907161 aagtttcaga tcaggcagaa agcttcaagc tggaatttta gttttcccag actgctaaaa 1907221 ggctcatttt gtgttaatta tgcaaaatgg tcaggttgat ttctttaaaa gcatgatgaa 1907281 atgttcatca tgctttttta ttgagaaaaa agacgaacat aaaaaatagg tatacgggaa 1907341 aaataatcct attagagaga ggggaactga cagatggata acatgatatc aacacttact 1907401 gactggaatg tgtggtttca agcgttagta gtatttctcg ttccatatgt aatctataaa 1907461 gtgtttactt ggattcatgt ataagaaggt gcaatgatga ggtggcggaa caatcagtac 1907521 aaaacacaga agcagcataa atcagattat tcgacagctg aaaagcagga tcaggatgtg 1907581 ttaaccggta acatcggata cgacttagaa catgtaaaaa gaaaaatagg acataacggg 1907641 gacgttcatt tccgtgagct tgaaatcact caattacatg tgaaagcggc attgatcttt 1907701 gttgaaggac tgtctgatca ggacttgatt aataaaggac tatcagtgtt agtcatgaat 1907761 caacctaatc aggtaagcga tgaaatttct caatccggca aaggtatttt aacttcgaaa 1907821 cagataaaaa atcaaatcgt atcaatcggt gatgtcatag attcagagaa aatcagtgat 1907881 atcgtgttga atgttttcat gggttcgaca gcgcttctca tcgatggaat accgcaggcc 1907941 tttcttctgg gaactgtaaa aaaacaaaat cgaagtatcg aggagccgct ttcagaagcg 1908001 cttgtcagag ggccgcgcac aggctttaca gaagagttga gtacgaatac agctcttttg 1908061 agacagcaag gaaaaaatga tcaattaaca ttgcagagat ttgaagtagg aacacgatta 1908121 aaaaaggatt taattatcgc ttatatgaat gacattgcag atccaaaagt agtcgaggaa 1908181 gtaagaaaaa gagtgagagg gattgagatc gatcatttgc cggagtcagg ctacgttgaa 1908241 cagttaattg aggataatta tttgagcccg ttcccgcaag tacagagtac agaacgtcct 1908301 gatcgcgtca taagcggatt aatggaagga agagtagcta ttctgcttga cggcactccg 1908361 tttgctttga ttgttccagt cactttcagc atgatgcttc aatcgcctga agattattat 1908421 gaacggtggt tcccgagctc gctcatcaga ttgctgaggt tcatcgcagc aatgataacg 1908481 ttattcgcac ccgctttata tatatcattt atttcttttc atcctgggtt aattccgacc 1908541 aagctggcga tttcaatttc cgggacgcgc caaggtgttc cgttcccatc tctgattgaa 1908601 gccttattta tggaagtcgc gattgaaatt ttaagagagg cggggcttcg tttgccaaaa 1908661 ccaattggac ccgcaatagg catagttggc ggattaatca tcggggaagc agctgtgcag 1908721 gcggggattg tcagtccaat catggtcatt gttgttgcgc tcacagcaat ttcttcattt 1908781 gccatcccgc attatagcac aggtatagca cttcggatgc ttcggtttgg cgcgatgttt 1908841 tgtgcggcgg tgtttggatt gtttggagtc attatgtatt atctgctgct aagcagccat 1908901 gtcgtaaagc taaagagctt tggtgtgcca tacgcaagtc cggcagtgcc ctatcactta 1908961 aaagattgga aagactttgt tatcagaatg cctcttttag tcatgaagcg ccggcctaaa 1909021 atgatgaata cagataatac aaaacgggtg aagtgatgaa ctcgacagga tggtgataaa 1909081 gtctcatgtt cagcccaacc agtaaaatca caaccgctca ggcaacgatt atcatcatta 1909141 attatatgct tgctgccgga gttcttacgc tccctcggac agtaacagaa caaacacaat 1909201 ctcctgatgg atggatttca gttttattag gcggggtcct agcggtaata gccgggatga 1909261 ttatagctaa attaagccag cagtatccta aggagacctt ttatgaatac tcccgacata 1909321 ttgtaggaaa atggctcggg catctgatca gtattgtttt tattacttat tttctggcac 1909381 tcggtgcatt tgaagtcaga gtcatgtccg aaatcgtgga tttttttctc ctcgaaggga 1909441 caccttcttg ggccatcatt atgacagttc tttggattgg gctttattca attacacaag 1909501 gcctagatcc gattgcacgg ctttttgaaa tgatttttcc gattacggtc atcatctttt 1909561 taacgatagc cctcatgagt ttaggcatat ttgagatcaa caatttgcgc cctgtattag 1909621 gtgatggaat catgccggtt cttagaggtg taaagacaac gaacctttca tttacatgtt 1909681 cagaaattat gttcatttta gtagcattta tgaaaaagcc gaaaaatgcg gtgaaagcag 1909741 ttgtgatcgg gacaggcgtt gtgaccagtt tttatatgat tacgatgatt atggtcatcg 1909801 gtgcactatc agttgaggga gttgtgacga gaacatggcc ggggcttgac ctgatgagaa 1909861 gttttgaaat acctggttta atatttgaac ggtttgaatc atttctgctt gtgatttgga 1909921 ttatgcagct ttttgccacg tttattatca ctttttatgc agcttccctg ggagtctcac 1909981 aagtttttaa aaagaaaccc ctttcatgta tgtttgggct gcttcctgtt atatatatcc 1910041 tctcttgcat gccgaaaaat gaaaatgacg tctttatatt gggcgatacg gtcagtcata 1910101 tcgctttgta tatatttggc gctttgccga ttttgctgtt agtcatttcg aaatggagga 1910161 aaagaggtga aaagtaaact aaaacgtcaa ttgcctgcta tggtcatagt atgtctgctg 1910221 atgatttgcg taacaggatg ctggagcagt cgggaaatag aagatctggg tctcacattc 1910281 gctatcgcaa ttgataaagg aaaagaaacg aacactgaaa aagagttaaa agaagagggc 1910341 gggagctatc cgaaaaaaga caacattacg ctgacctatc aatttgttaa tgaaaaagcg 1910401 gcaggcgcgg gcacaagcgg gggaggcggt agcggacaag gagcgcaaaa agcgtacatt 1910461 aatataagtg aaacagggga ttcattacag cagatcggaa gtgaggttgc attaagacgg 1910521 gaccgagaag tgtttagccc gcatttaaaa gttgttgtca tgagtgaaga tgtgctgcac 1910581 acatttccta tcgacgaaat gctggatcaa ttttttcgtg ataatgaaat caggctgagc 1910641 tgtcttgttt tatctgctaa aggggaagca agagacgctc tccagctgaa agagaacgga 1910701 gaaattccgg catttcggct gattggatta ggtgaaaatg aacataaagt ttccagaatt 1910761 cttcccccta tgacactcgc gaaactaatt ggaaaactgc attctggcag cagcttttta 1910821 ctgcaaaatg tggttgcggc gaatggagcg gtcaagtatt ccggagcagc tgtaatcaac 1910881 ggaaaatcga aaaaaatgat aggcacctta aatgaatatg aaactgaggg gattacatgg 1910941 attagaggag aagggaaagg cggagttgtc aaaagtcatg ataaaaagag ccaacagacg 1911001 ttagcgtacg atatcaataa aatcaaaagc agaattcagc caatcgtaaa agggaaagat 1911061 atttcattcc atgtcgatat tgaatcagaa ggcgatttgg ttgaaaactg gaacacaaaa 1911121 gaggcgttgg acacccagtt tatagatcgt ctcgaaacga ctattgaaaa cgaggtaaag 1911181 aaaatagttg gtcaggtatt aaaaaaaatt cagcatgatt ataaagcaga tgttgcgggt 1911241 tttgatgaat cttttagact tacatatcct cacttatgga aaagggtgaa aaataactgg 1911301 gatgacacct tcagtaaagc cgacatcaca tacagtgtga acgtcacaat tactcatttc 1911361 ggcacggtta aaactcagta atgaatccca aggaagagaa ggaaacctct cttctctttt 1911421 ttatgcattt attaggataa agatactttt tttggagaga tatacacttt tcaaatcgac 1911481 caatatgcta atataggaat tgcttgaaat agaagggaga aggggctgtg aggcagaaac 1911541 cgatttatgt agaaatcgaa atgaaatctg atctggatac actctgggaa tatacacaaa 1911601 acccatcact gcataaggaa tgggatctcc ggttttcaaa tattacgtat ttgaatagtc 1911661 agccatgcga aaaacagaag tttctttacg aaacaagggt aggctttgga ttaaaggtgt 1911721 caggtacagg agaaaccgtc ggtgttttca acaaatgttc atctgaaagg tcttcttcac 1911781 tggcttttgg ctctgatcat ccattatctc tgattcggca tggaagcggc tactggaagt 1911841 atatacagag agaaaatggg aaaatgacgt ttttaacaca gtaccaatac aaaacagcct 1911901 acggactgct gggaagatgg attgatcgtt tattatttcg gccgctgctt ggctgggcga 1911961 ctgcctggag ctttgatgca ttaaggcttt gggtagagca aaataaacat ccgaagcgct 1912021 tcattcgatc tgctatcatc tatgtgttca tgtgtctgtt tttcagcctg ttttggttct 1912081 atcaaggctt tgcaggtgtt aagacaagca tattgacagg aacagcggag ataggcttag 1912141 ctattttgtg gctgcttcct ttaaaaagaa aatggatcat tcatggtgtc caggcttgta 1912201 tttttgctgg gtttgcttgt ctaggttccg aaatattcat gtgggttcta ttgagtgtgt 1912261 tttccgctgc aagcggcgct cttagcctgc agctccccag tgccaggcgc acaaaacgaa 1912321 agagaaagaa gtgacattgt gagttcgatt tatgaaaaat caattattaa ctatcatttg 1912381 ctgcatccca agctgcagaa acggtaccaa ttagacgggt ctcatacatt cagcgggacg 1912441 ggaacgatgt cagaaataag cggaggctct tttctggtta gaatgctgtt aaagctgggt 1912501 gtttttttca gatgcttctt ttcagaaaga ggcaaagaca ttccatttac aatacaaaat 1912561 agaacttgtc ttttgaaatc gcaacataca ggaatagaat ggaatcgtac atttttcttt 1912621 aaaggcaaaa aacgtttctt tgatgcgtta atgatatatg acgagaaaga aaatagaata 1912681 cttgatttct tcggcaaacc tcatctgctg ctgtctgttt tgacgttcga ggcatctctt 1912741 gacggctctc ttacgatcac atcgggaaag caatggctat tgatatgcgg aaaaagaatc 1912801 ccgctgccga aatggctgac cggtacatcc gaagtttgcg aaacgtttga tgaaaaaaag 1912861 aattgtttca ccattgaagt gcatgtgcaa aatacaattc ttggcactct tttcttttat 1912921 aagggaacgt ttcaggagga agagagagaa tcatgaaacg aaatggcata gtcagtgcgc 1912981 tttgttttat tggatttctt gcagcagaag caccggatat ttcagtggca gaggcactcg 1913041 ttttgttatc cattctattt ttcgtgccgg gaatttttcc ttttgttttt cgtcaatctc 1913101 cggttcgtgc tgctcagttt atggaaaacg ggctaatcca gtgctatcct gtagccgcat 1913161 tctttgcggt gctggctcta gtgacggagg ttgggggttt cgcacttatc tggtggatgt 1913221 acacagtttt taatgcattg tatgcgatcc tccgcctttg ggaaacaaag atacatagaa 1913281 tcgaagagac atcagttttg ttcggtctta tttatttggc gggaggagga ttttggtttt 1913341 ttgcttatgc tgcccatttg cagatcatgc aatttggccc tctcatcatt ttgctgactg 1913401 ctgtccactt tcactattct gcttttctga tcccgatctt caacggttta ctcggcagaa 1913461 ccattagaaa acatcggatg ttgtacagtt ggataacatg ggtgattttg ctttcgcccc 1913521 ttcttatcgc actgggcatc acatattcaa aaacacttga tgtcattgcg gttagcattt 1913581 atatggcggc gatttatctt catgcatttt tggtgttcac ggcagctttt cgcaccaaga 1913641 cggggacatt tcttattcgg ctttcttccg ctgttttaat gataacgatt gctttctcga 1913701 tgatttattc atttggtgtc tttcggcaag aagttacatt gaccatcaat cagatgattt 1913761 ggattcacgg ttttgtcaac gcgtttggtg ttatcttgcc cgctctcata gggtggagaa 1913821 tagaggatgc gaaacctttt gatgcagaca gtgtaaagac attcagccgt atctacggaa 1913881 aaagaaagat tggagaagaa tttttagcta acattcaagc tgaaaataac gctcggtaca 1913941 gcggacttgt ggatgatatg ggcagcctgc gttcaaaaga tttttcacca gaaaaactgg 1914001 cgccgctcat tctttcgttt tatgaacaaa ccatcgaata caatattaaa gcaaaagtaa 1914061 catggagcac gtggtttcgg ccgcttgcaa ttatttacga atggttcagc agaagaatcg 1914121 gccaaataca tctttcgacg aaccctgact ggtataggat gtacagcaag ataaaaggtg 1914181 ttcattcgaa aaaagacgga agggaaagag tacgtgcctg gattagaaca aatgaaaaaa 1914241 acgaaaccat ttttaccgct ctttattcag tgtatcgttc aaatggagag gggtatatga 1914301 atatttcttt accgcttcca ttcagcagca tgacaggtat tttaaaacca tatcatcatc 1914361 aggagaagct ggttttaaca agcaggcgga gaaaaagcag agcgggggat gaggggattt 1914421 atctgcaaac aagagcggga acttgtccgc ttcctttatc tgaaaccttt ctgatagaag 1914481 ctgtacatga caacaaatta accgctgttc atcatatgtg gctgtttgga ataaaatttc 1914541 taactgttca ttacagcatt acacatatta accagcctat tgaaagaacc taacacaaag 1914601 aagaagcttc gtctgccagt tgtaatgaga tgaactgttt taaaattctg caccgcatca 1914661 agacaggaaa ggaagggttt atggtgtttt atatcagttt atttctgatt ctttggctgg 1914721 ctgctgggtt tgcagtggga atgaaacaag tgtatgtcga tcagctgttt gataaagctg 1914781 tgatcgaaag actggaaaaa gaagcgaatg atcatggaca tgctgaccgg atgatcaaac 1914841 agcgcgtcct ttatattgca gcagtgacag taagcgggtt tatttctgtt tattatgaaa 1914901 tgaaaacaat cccgcaaagg cgaaacataa gaaaaattga aaaaaacatc atgaaattaa 1914961 atcaagcaaa aaaacgaaga atgaagagaa aataaaaagt gcacaggcca aagggcaggt 1915021 gcatttttgt tttgtatgga aaatggggga ggtggtgcca gcttactttt cataaattca 1915081 aaaatgagaa gaacagcgcc cgggctaatg gtatataata ttgtgaattt aacaaaaatt 1915141 taacaaggag gacgagagaa ttcgtgctaa agcctcaaag agacctacat tctgttgatt 1915201 tggacttaga ggcggagtag atgaaaccgg ccaaagtatc cctgctccgc cgtttgctcc 1915261 attccttgaa gcatgttgat tgtaacatag ccaaacgttt tccatcaact attaaaattg 1915321 taaaattatt gatgattttt atggtgttta ctccgatttc ttcaatttat gctgaagatg 1915381 tatatcagaa ttttgaggaa ttaaaaaaca atgaagatcc ttctgattat ggcgttgtta 1915441 cgaaagaaac cggaagccct gttcttgttt tagctattca cggaggaggt attgaaggcg 1915501 ggacaagtga agtagcgaga gagctcagca aagagtactc gatgtattta tttgaaggct 1915561 taaaatcggc aggaaactca gtcctgcaca ttacgagcac acactttgat gaacctcggg 1915621 cccttaaaat gacgggaaat catgaatatg tcatttcatt acacgggtac gcagaagaag 1915681 atcagcagat cgaagtcggc ggtacagatc gcgtaagagc ggcagattta gttgagaaat 1915741 tgcagcatgc cggttttcct gctgtattgc tcaatatgga ccatccgcat gcgggcgtta 1915801 gtccgaataa cattgcaaat aaatcaaaaa caggtttaag tattcagata gaaatgagca 1915861 cagggtttcg aaagtctttg ttcggcatct tttctttaaa aagcagagct gttactcaaa 1915921 atgagaggtt ttatgagttt acagaagtga tgttccgttt tctcaaaaat agctactgaa 1915981 aaataggagg cgataagaca gcctcctatt ccttatgctt ctctttcgtt tcgggaaaca 1916041 gctcgtccgc ggcttccgtt tgatactgca acgtgttatc tctcgctgac agttcatttc 1916101 ggaaattttc atcaagcaca tttttcagta aataccgatg aaaaaagtat tcaaaaacag 1916161 taagacaggc agcggaaagg agagccgctc caaatggtga gaaatcgttt cttgtttggg 1916221 ttaaaacaaa tacccaaaga ataacgaatg aaaggccaaa gtcagccaat gaagctgtaa 1916281 tattgtttgt tctgggtaag acgagcatgt caccagaaag ataggaaaca aaacctaaga 1916341 aaagtgcaat aaacatcaca cttaaaaagg atgcgtgata gactctgtcc aaaatcacat 1916401 ataaaagggc gagagtgaaa gcaatctttg aagcaagcgc aatgatatgt ttcatttgac 1916461 cacctaaatt gttatttttt gaagaaaatt cttgggcgta aacaaatgat aaataatgca 1916521 attcaaaacc attcataatg gtcatgttac tattttaaac agtccgtttt tgtttacact 1916581 ggtatttttt tcagctgtat gaaactttct tatgaaaaaa gtcgtatatg tggatgatca 1916641 gctttcaagg ggggaatgat ttgtggagat aaaaggaatc aatcacttgc tattttcagt 1916701 ttcgcatttg gatacatcga ttgattttta tcaaaaagtg tttggtgcaa agcttttggt 1916761 aaagggaaga acaactgcat attttgatat gaacggcatc tggctagcgc ttaatgaaga 1916821 accagacatc ccgagaaatg acattaagct ttcttatacc catattgctt ttacaattga 1916881 agatcatgaa tttgaggaga tgtcagctaa attaaaaaga cttcatgtca atattctgcc 1916941 tggcagagaa cgagatgaac gcgatcgaaa atcaatttat tttaccgacc ctgacggcca 1917001 caaatttgaa tttcataccg gaacccttca agacaggctt cgatattaca aacaagaaaa 1917061 aacgcatatg cacttttatg atgaaacggc cttttgatag cacaaccata tttcatataa 1917121 ggttaaattt aaagaagggt gttggtggag actttatgtt tggggaaggt ttctacccga 1917181 cttgttcaac gatgccatat cttttgaact gcacaagtga ttgggtgaag gtgaaattga 1917241 aatacacatt acattacatt ttatatgaag aaagcgagct gttttatcaa atgttgaact 1917301 aattaaacta tgtactaaat tttcagtata tttcaattgc tttgcccctt aataaatata 1917361 aaaccgcatc cttccacgac ctaaaaaatg aaacgttttt aagaagatgg cgtctaatat 1917421 tctaaatgtt catattttga taaaagtttc ctaaaggaaa gaaaatttct tgacttcaac 1917481 aatcttttgg tggataatta tggtgtaaac atgatgttct ttttcctcct attcgggctc 1917541 gcacccaaaa gtcagggcga gcctgctttt tttgaacaac aaaccccctc tccgtaaagg 1917601 aagagggggt tattttatgc atctgataga tcaatagatt aatggacggt tctgaacacg 1917661 ccaatcactt tccctagaat gctgacattc tgcaaaatga taggttccat cgttgggttc 1917721 tcaggctgca agcgaatgtg ggtatcctct ttatagaatc gttttacagt tgcttcatca 1917781 tcttctgtca tcgcaactac aatttcccca ttgttcgctg tgttttgctg tttaacgatg 1917841 acatagtcct tatcgagaat accagcatct atcatactgt ctcccataat ctccagcata 1917901 aatacatgct cgtctggagg aaccatgcgg tcagggagcg gaaaatattc ttcaatattt 1917961 tctactgctg taataggaga tcccgccgtg actttcccga tgaccggtac attaacgacc 1918021 tggctttgcg gaatgtctac ttcttcatca agaatttcta ttgctcttgg ttttgtcgga 1918081 tctcgtctga tcagcccttt tgtttccaaa cgggccaaat ggccgtggac agtagaactg 1918141 gacgcaagcc cgacagcctc tccgatctct ctcacggaag gcggatatcc ttttgattta 1918201 acctctgctt taataaaacg gaggatatca agttgccttt ttgatagctt cgtcattttt 1918261 cgcacctcaa aacgtcgatt ttaagaagat tatagcatga ttttccttac agtacaaaca 1918321 taggttcgaa aaaacaattg acagaaacgt ttgttcgtat atactgaaat tataaaaatg 1918381 cgaacaaaca ttcctgttgg aggttatgat catgagtaaa gaatctatta tttttgtcgg 1918441 tctgtttaca gtgattttga gcgcggttat ccttatgctg tcatatacaa gcagcggcca 1918501 agagcttaat cagtatgtta aaatagaagt ccagcaaggc gacacactct ggtcaattgc 1918561 tgatcaggta gccgatacaa aaaagataaa caaaaatgat tttattgaat gggtagctga 1918621 taaaaatcaa cttcaaacct ctgatatcca gccgggtgat gagttagtga tcccattgaa 1918681 aaagaagcat caggatgcat atgaattagc aactgtaaga tagagaggaa agagagataa 1918741 aatgaaagca ctcatttatg cccgtgtaag cacaaataaa gaacagcagg aaacgtcatt 1918801 aaagcggcag gaggaggagc ttacggccat tgcagcggag aacggcatgg aagtggtcaa 1918861 agtgatttca gaaaaagcca gcggatatga aatggatcgg gatggtgtat ttgagctgct 1918921 cgatgagatt aagaacgctg atattgatgt cattttggtt caggatgaga caaggctcgg 1918981 acggggaaac gcaaaaatcg cactgcttca ttgtatttat agagaaggtg tgaaagtcta 1919041 tacaacggct catagaggtg aactggagtt atcggaggct gactcaatgg tcttggaaat 1919101 cgtcagcatt gtggaagagt atcagcgaaa gattcacaac atgaaaatca gacggggaat 1919161 gaaacgtgca gtaaaaaacg gttttaaacc gcaaaaaaac ttaaaaaacc aacatgggaa 1919221 cagtggaaaa gaaaaaatag aggtgccaat ctcagagatc gtccgcctga gagcgaataa 1919281 actgacgttt gctgaaatcg cggctaccct aagagggttt ggctatgatg tctctaaagc 1919341 aaccgttcac cggcgttttc aggaatacat agagaatgaa gagactgcag agtgaatcag 1919401 ttgtaaaact ttttttgatc tagtactata tagacaaaat gcaataaagg agtttaacat 1919461 gatttcaaac gcgaaaattg ccagaattaa tgaacttgct gccaaagcta aagctggcgt 1919521 tattacagaa gaagaaaaag ccgaacagca aaagctccgt caagagtact tgaaaggttt 1919581 tcgttcttct atgaagaaca cgttaaaaag tgtgaaaatc attgacccag aaggcaatga 1919641 tgttacacca gaaaagctaa aaagagaaca aagaaataac aaacttcact aatataagag 1919701 gaatacggca atatcgtatt cctcttttgc atatactata atcaaaactc ttatgtgaca 1919761 aaattcaaca agtttctctc aaatttaagc tgaaacagtt gagaaaaagt cgtcagacat 1919821 ttatgatgta agggtacaac acataaggaa ggggattttt atggatacaa ttgaaaagaa 1919881 atcagttgct accattcgca cactgtcaat agacgctatt gaaaaagcaa attctggtca 1919941 cccagggatg ccgatgggag ccgctccaat ggcatacacg ctgtggacaa aatttatgaa 1920001 cgtaagtccg gcaaaccctg gctggtttaa ccgtgaccgt tttgttttat ctgctggaca 1920061 cgggtcagca ctattataca gcatgcttca tttaagcggg tttgatctta gtattgaaga 1920121 tcttaaggga ttccgccagt ggggcagcaa aacaccagga catccggaat tcggacatac 1920181 tgccggtgtt gatgctacaa caggtccgct tggccaagga attgccatgg cagtcggtat 1920241 ggcaattgct gaacgccatt tagcggaaac atacaaccgc gattcattta acgtagtcga 1920301 tcattataca tacagtattt gcggtgatgg tgatttaatg gaaggtattt cttctgaagc 1920361 cgcttcactc gcaggccatc ttcagcttgg ccgtctgatc gtactatacg attctaatga 1920421 catctctctt gatggagacc tcgaccgttc attctctgaa aacgtgaaac agcgttttga 1920481 agcaatgaat tgggaagttc tttatgttga ggatggaaac aatattgaag aattaacagc 1920541 ggctatcgaa aaagcacgcc aaaatgaaaa gaaacctaca ttaattgaag tgaaaacgac 1920601 aatcggattc ggttcaccta accgtgccgg tacatccggt gttcacggtg cgccgcttgg 1920661 taaagaagaa agcaaattaa caaaagaagc ttacgcgtgg acatatgaag aagacttcta 1920721 cgttccgtca gaagtttatg agcatttcgc tgtagctgtt aaagaatcag gtgagaaaaa 1920781 agaacaagaa tggaatgctc aattcgctaa atataaagaa gtttatcctg aacttgctga 1920841 acagcttgaa ctggcaatca aaggagagct tccgaaggac tgggatcaag aggttcctgt 1920901 gtatgaaaaa ggaagcagtt tggcatcccg tgcatcttcc ggtgaagttc tcaacggact 1920961 tgcgaaaaaa attcctttct ttgtcggagg ttctgctgac ctagcgggat cgaacaaaac 1921021 gactattaaa aatgccggtg attttacagc ggttgattac tcaggcaaaa acttctggtt 1921081 tggtgtacgt gaatttgcga tgggtgcggc cttaaacggt atggcgcttc atggcggtct 1921141 tcgtgtattc ggcggaactt tctttgtctt ctctgattac ctgcgtcctg cgattcgcct 1921201 tgcagcgtta atgggccttc ctgtgacata tgtcttcaca catgacagta ttgcggttgg 1921261 tgaagacggt ccgacgcacg agcctgttga acagcttgct tcactccgtg cgatgcctaa 1921321 cctttctttg atccgtccag cagacggcaa tgagacagca gcagcatgga agcttgcagt 1921381 gcaaagcact gaccacccaa cagcgctagt gcttacacgt caaaaccttc ctaccatcga 1921441 tcaaacatct gaagaagcat tggcaggagt agaaaaaggt gcatatgtcg tttctaaatc 1921501 taaaaacgaa acacctgacg ctcttctcat cgcttccgga tcagaggtag gtcttgcaat 1921561 tgaagcgcag gctgaattgg caaaagaaaa tatcgatgtt tctgttgtca gcatgccttc 1921621 aatggaccgt tttgagaaac aatctgatga atacaaaaac gaagtccttc ctgcagatgt 1921681 gaaaaaacgt cttgcaattg aaatgggctc atcatttgga tggggcaaat acacggggct 1921741 tgaaggtgac gttctcggca tagaccgatt cggtgcatct gctcctggtg aaaccatcat 1921801 taacgaatac ggcttctcag ttccgaacgt agtgaatcga gttaaggcat taatcaataa 1921861 gtaagctttt gaaagaggat gagtcaaatc atcctctttt tcttgtttat ccgacaaaaa 1921921 tagtattggc tgtttaacag taatagacaa ttctttcttt tcttcttttg tataatagag 1921981 agcaaatgaa atgctgctgg aaaaggggat gaaaagatgg aacgtcacta ctatacgtac 1922041 ctgatcaaag aggaatttgc caatcactat ttcggccggg aatcggttat gtttgagctg 1922101 tttcaagact atcattggac aagccttgaa aagcagcagt atgaaatgac agagaaacag 1922161 attcaatata ttacacaacc aatcccgatt ttacatatgc atcagcggtt aaaaatgaat 1922221 ttaaacaaga cggattacag gcagctggat tatatttata gaatagcttt gccgaaagca 1922281 aaaggccacg cgacgtttat gatgaaggag cacatgatag aaattgtggc ttcgggagat 1922341 tacgaggcag aaacgatatt ctttgaagtg ttaagaaaag taagcccttg ctttttagca 1922401 atggatttca attcgaagcg ttacggatgg ctaaatccgg tgaaagaaag aaattttgtc 1922461 taaaaccgaa gaaaaagaga tgtaaatgtt gtataatagc ttttggttta gtacacttta 1922521 aactagacaa catgaaggag gaaataaaat gactttatgg gttggcatcc tagtgggcgt 1922581 tgttgcattg ctcataggtg ttgcactcgg gttttttatt gctcgtaaat atatgatgag 1922641 ctacctgaaa aagaatccgc ctattaatga acaaatgtta cgcatgatga tgatgcaaat 1922701 gggaatgaaa ccttctcaaa agaaaatcaa tcaaatgatg aaagccatga ataatcaaac 1922761 gaaataatac gtaaagatta tgatatagag aaacatggtt ataaaataaa aaacccttat 1922821 acgggttttt tattttgcaa tcattcatca cccgctactg ctcgaaggcg ctgcttttga 1922881 tattgtatga gaagatggtc aagctcctga ctgagctcta tcgtaatatg agatgtcatt 1922941 ccgttcgcca tgacaatttg cagcagctct gctctttttt tttcaatttc ttttaataga 1923001 tgctctctaa tcacagggat gtatcctttc atacattaga tcttcaaagt gaatgtttat 1923061 attatatcca tatttatact aattttcaaa tgagaaggag tataatgtct caatgtcaaa 1923121 ttaaattata taagtttttt ctgaaaatag aaatccttca agtgaaagtg ttaaaaaaat 1923181 gaaatgattt tgtcataact tgaaggaatg tcaaatcatg aagggatgat gacatgggag 1923241 acgtgaatta ttttttgaca ttcggagcgg ggtttttatc ctttatttcg ccttgctgcc 1923301 tgccgcttta cccagctttt ttgtcatata ttacaggggt cagcatggac gatgtaaaaa 1923361 ctgaaaagct gctgctgcag aaaagaagct tgtttcatac tttgtgtttt ttgcttggct 1923421 tttcagtcat ttttattgct ttaggctatg gaacatcttt tattggcagc ctgtttaggg 1923481 attatcacga tgcgattcgg caaattggcg cgttgcttat tattttgttc ggtttcatta 1923541 cactcggtgt gttccggcct gaggctatga tgaaagagcg gagaatccat tttaagcata 1923601 aaccaagcgg gtttttaggg tcggtcttaa tcggaatggc atttgcagct ggatggacac 1923661 catgtaccgg tccgatatta gctgctgtta tcacacttgc aggcaccaat ccgggctcag 1923721 cggtgccata catgatgtta tatgtactcg gttttgcggt accgtttctt ttattgtctt 1923781 tttttatcac aaagctgaag tggataagga agaaccagct tttcattatg aaagctggtg 1923841 gcgttttgat gattgtgatt ggtgtgctgt tattctttaa ttggatgagc ctgatcatta 1923901 ttttgctgtc agatcttttt ggaggcttta ctggtttttg acggtaaatt actttcgtac 1923961 tactactaat ccttttgttt ttggtacaat aagactatta tctgtggaaa tcgattgttg 1924021 gaggggaata tgacaagagt tttagttgta gacgacgcca agttcatgag agtgaaaatc 1924081 agagagatct tggaagaggc aaattacata atcgcaggcg aagcggcgga cggtgaacaa 1924141 gcagctgacc tgtataaaaa actgcgcccg gaccttgtga caatggatat tacaatgccg 1924201 gtgaaaaacg gcataaaagc gcttcgtgat atcttaacct ttgatcctaa agcgaaggtc 1924261 atcatgtgca ccgccatgcg ccagcaaaga attgtaacgg aagcaattga gctgggggca 1924321 aaggatttta ttgttaagcc gtttgaggaa acaaaagtgc tggaagctgt aagccgcgtt 1924381 atgggacatt aaagtcattt cttttcaaaa tggttttttt tattgttttg gagtatagta 1924441 tatagtatca acactccgag aaacaaagga atgataagta tgatgattat agtttcatca 1924501 attattgctg tgttaatggc tgtagctgtg atggtggtca gaataaagtc ctctgacaag 1924561 cctgtttcac caaaaaaaat cattcttccg ccgattttta tgagtacggg agcgttaatg 1924621 tttttatttc cggtattttg ggtaactgga gcagagtttt tggaagcatt cactttaggt 1924681 gtgattttct ctatttttct aatcaaaact tctaagttcg aaattaaaaa taatgaaatt 1924741 tacatgaaac gctctaaagc atttgttttt atattagtcg gtcttttggt gatcagaatc 1924801 gtgatgaaat cgatcttgag cacatcaatt gattatggtg cactgagcgg aatgttttgg 1924861 attctggctt tcggtatgat tgtgccttgg agaatcgcca tgtatttatc atatcgaaaa 1924921 cttcataacg agctgcagtc atctaatatt caaatgaatt aaaaaacctt tcctcttgtc 1924981 aggaaaggtt ttttatttga gaagggtctg ataaggttcc aaatcgattt ttttgtcccg 1925041 cagatgcctt tttaagaagg tatggtctct tttaggagtt gcgagaatat agcctttgat 1925101 cataagttgc tgatcaatct ttgctacctt ttcttttaat gcaagctcac cgattttgcc 1925161 tgcgatttta gcttttgctg catctctgaa cagctctggc acgggcgcag tcaattcatc 1925221 tagaaactgt ttgttttcat cgttccataa atgtctgctg ttttcaatat agtaatcctg 1925281 ccaatcaagc tctgatctgc cgtcctcttt tggtaaacgc tttaaaaact ttcgaaacat 1925341 gaaaaaaccg ccgattgata ataagactac catcatgatt acccaaaaca gaataaacca 1925401 taaaaaccat ccttccagca tcaatcattc ccccttattc taaccatatt gtatacgaag 1925461 agagattaga agaacacagt aaaaaaagaa tagaaaaaag tgatagacgt ctagtcaaaa 1925521 gagatagtag atcatattct attgtatagt gaatctgcta tttggccatg ggagagtcac 1925581 tagagggtat ttgacgataa atggacggaa aaaaagtcac tttcataata ggggatgaaa 1925641 gtgacttttt atgtttagct gagaggaaat tgaagagaaa aagaagagcc atcttctgtt 1925701 tctttattga cggcgactgt gagtatttga ttttcgcatt cgacttgaat gtttttgtca 1925761 ttaaaataaa aaggaagcat catttgtttt tcaaaagtct gtcctgacga tttgacagtt 1925821 aagatgaact cgcatccaga aagggtaact gttacttgtg taggctgtaa aaaagtcaga 1925881 tccgcttcta taatatactg ctgacttgtt tcatataaat caataggcaa tgtttcgtcg 1925941 taccaggcga aggggtcttc aaaaaattgc cgaagccatt catccatact atcgaaatca 1926001 ttcgcatcgt tgcgttttga atggttcatg gaagcattcc tccacatatc aaccttgctt 1926061 tacatcatat gcggtggatt ataaatgggt gaacgcataa aaaaacagac actaaggtct 1926121 gcttttctta catatcatgg cttgagttgt gcttttgtct tgtatggttt cggtttttta 1926181 cttttttgct tccgcttaga ggctcgggtt ggccgggatt gtgtccttta ggggcgtttt 1926241 tatgcatatc tttacttgta ttcttattgg tcataaaatg agaacctcct taaaagagtt 1926301 cggtgttatt gattggtttt tctttttttg ttattttggc gttctgcttc agtcagtaca 1926361 agctggtcgt tttcaatata gccggcgcct ttgccttggc tttttgcgtc attcattccg 1926421 ttaatgacgt gattcgcttt tcttttgacc atcattatca cctcaatcat aatatggctt 1926481 cttttattgt gttatatgag agagcgtaaa cagtaaaaat taccggtaca tttttctcat 1926541 aagtcgaact tattgtattt aataaaaaca ttgatattta cttatgtatg attttgtttt 1926601 aatatgaaat tgtgagaaaa ttgtgatgga atgtaatgtt catctgagaa tgatctgatc 1926661 tgaaggggga ttttggagaa tggcaaacga gcaaaaaact gcagcaaaag acgttttcca 1926721 agcgagaaaa acgtttacta caaatgggaa aacatatcat tactactctt taaaagcgtt 1926781 agaagattca ggtataggaa aggtttcgaa gcttccttat tccatcaaag ttcttttaga 1926841 atcagtattg cgtcaagttg acggcttcgt tatcaaaaaa gaacacgtgg aaaatttggc 1926901 aaaatgggga actgccgaat taaaggatat cgacgttccg ttcaaaccgt ctcgtgttat 1926961 tttacaagac ttcacagggg ttccggcagt agtagatctg gcttcactgc gtaaagcaat 1927021 ggcagctgtc ggcggagatc ctgataaaat caaccctgaa attcctgttg atctcgttat 1927081 cgatcactct gtacaggtag ataaagcggg tacagaagat gcattagcag taaatatgga 1927141 cttggaattc gaaagaaatg cagagcgcta caaattttta agctgggcaa agaaagcgtt 1927201 taacaattat caggcagtac cgcctgcaac aggtattgtg caccaggtca accttgagtt 1927261 cttggcaagt gttgtccatg ccattgaaga agacggcgag cttgtaacgt atcctgatac 1927321 gcttgtcgga acagactcac acacaacaat gattaacggt atcggtgttc tcggctgggg 1927381 tgtcggtgga attgaagctg aagcgggaat gcttggacag ccttcttact tcccagttcc 1927441 agaggtaatc ggcgcgaaac ttgtcggcaa gcttccaaac ggaacaacag ctactgactt 1927501 ggcgttaaaa gtaacacaag tgctgcgtga aaaaggcgtt gtcggtaaat ttgttgaatt 1927561 cttcggaccg ggaattgctg aactgccgct tgcagatcgc gcaacaattg cgaatatggc 1927621 tccggaatac ggtgctacat gcggattctt cccagtagat gaagaagcgc ttaactacct 1927681 gcgcctgact ggccgtgatc ctgaacatat tgatgttgtt gaagcatact gcagaagcaa 1927741 tggcttgttc tacactccag atgcggaaga ccctcaattt actgatgtgg ttgaaattga 1927801 cctgtctcaa attgaagcaa acttatcggg tccaaagcgt cctcaggatt tgatcccgct 1927861 atctgctatg caggaaacgt ttaaaaagca attagtcagc cctgcaggta accaaggatt 1927921 cggtttaaat gctgaggaag aaaataaaga aattaagttt aaactcctta acggcgaaga 1927981 aacagttatg aaaacgggtg cgatcgccat tgctgcgatt acaagctgta caaatacatc 1928041 aaacccatac gtgctgatcg gcgccggact ggtagcgaaa aaagcggttg agttagggct 1928101 taaggtgcct aattacgtga aaacgtcact tgcaccgggt tctaaagttg ttacaggata 1928161 tcttgtgaat tcaggccttc ttccatacat gaaagagctt ggctttaacc tcgttgggta 1928221 cggctgtaca acatgtatcg ggaactcagg tccgctttca ccggaaatcg aagaagcggt 1928281 tgcgaaaaat gatcttctga ttacgtctgt cctttccgga aaccgtaact ttgaaggacg 1928341 tattcacccg cttgttaaag gcaactatct tgcttcaccg ccgcttgttg tggcatatgc 1928401 gctggctgga acggtaaaca ttaacttaaa aaccgatcca atcggtgtgg gcaaggatgg 1928461 tcaaaacgta tactttaatg atatttggcc gtcaatggac gaaatcaatg cacttgttaa 1928521 gcaaactgtt acgccagagc tattccgcaa agagtatgaa acagtatttg atgacaacaa 1928581 gcgctggaac gaaattgaaa caacagatga agctttatat aaatgggata acgattcaac 1928641 ttacatccaa aacccaccat tctttgaaga gatgtctgtt gagccaggca aggttgagcc 1928701 attaaaagga ctgcgtgttg tcggtaaatt cggcgattca gtcacaactg accatatttc 1928761 tcctgcgggg gcaatcggaa aagatacgcc tgccggaaag tatttgcaag aaaaaggtgt 1928821 ttcacctcgt gactttaact cctacggctc ccgccgtgga aaccatgaag tcatgatgag 1928881 aggaacattt gccaacattc gcatcaaaaa ccaaatcgca ccgggtacag aaggcggatt 1928941 tacgacgtac tggccgactg gtgaagtaac atccatctat gatgcatgca tgaaatacaa 1929001 agaagataaa accggtcttg tcgtattagc aggaaaagac tatggtatgg gatcttcacg 1929061 tgactgggct gcaaaaggaa caaaccttct cggcatcaga acggtcattg cagagagctt 1929121 cgaaagaatt cacagaagca atcttgtatt catgggtgtg ctgccgcttc agtttaaaca 1929181 aggtgaaaat gcggatacac tcggcttaac gggtaaagaa gtcatcgagg tagatgttga 1929241 tgaaacagtt cgtcctcgtg accttgtgac tgtaagagca atcaatgaag acggcaatgt 1929301 aacaactttt gaagcagtcg tccgctttga tagtgaagtt gaaattgatt actaccgcca 1929361 tggcggcatc cttcaaatgg tgcttcgtga aaaaatgaag cagtcctgat gaatcaatag 1929421 gaagagaagg catttcgctt tctcttcttt ttatgacaca atgtgctgcg gaggtggcat 1929481 atgctgaaaa aatggctcgc agggatcctg cttatcatgc tagtcggtta tacgggatgg 1929541 aatttatatc aaacatacag caaaaaagaa gtcggaattc aagaggggca acaagcacct 1929601 gatttttctt tgaaaacgct atcaggagag aaaagctctt tacaggatgc aaaaggcaaa 1929661 aaagtgctgc tcaatttttg ggcaacttgg tgtaagccgt gccgtcagga aatgcctgcg 1929721 atggaaaagc tgcaaaaaga gtacgccgac aaacttgcgg ttgttgcggt aaatttcact 1929781 tcagctgaga aaagtgagaa acaggtccga gcgtttgctg atacttatga cttaacgttc 1929841 cccattctga ttgataaaaa agggatcaat gctgactata acgtgatgtc atatccaacg 1929901 acatatatct tagatgaaaa aggtgttatc caagacatac atgttggcac catgacaaaa 1929961 aaagaaatgg aacaaaaact ggatcttgat tagattcagt tttttttata ctcaaatatg 1930021 cttacaagtt ttcagaattg gaaaaaataa aagaatatgc ggaggtgaga agcgtgaaga 1930081 agatgagaaa acgttctttt catgagctcg tcatggaaaa caaaaaagag ctgatgacca 1930141 atacagagta tttaaatcag cttgaggaaa agcttgaaca gcgatttaag caaaaataac 1930201 ctttaatttg tattcatgtt tacccctcct tttgagaaac ctatctgttg aggagggata 1930261 aacatgggaa acaacaagaa aaacggtcag cctcaatatg ctccaagcca cttgggtaca 1930321 aagcctgtaa aatataaagc caataaaggg gaaaaaatgc atgatacttc aggacagcgg 1930381 ccgattatca tgcagacaaa aggcgagtag cgaaaattcg agtttatttc taggaggtac 1930441 atccgaatga caaagaacca aaatcaatat cagcagccta atcctgatga tcgttctgac 1930501 aatgtggaaa aattgcagga tatggttcaa aatacaattg aaaatataga agaagcagaa 1930561 gcatcaatgg agtttgcttc aggagaagat aaacagcgta tcaaagaaaa aaatgcaagg 1930621 cgcgaacaga gcattgaagc gtttcgtaat gaaatacagg acgaatctgc agcgagacaa 1930681 aacggatacc gttcttaaaa aaccagggaa acctggtttt tttctttctg atttgattat 1930741 ggtaaaatgg ggctaaattg acgttaaggg agcagagtaa tcttgcatgt atcaaaaaaa 1930801 gaaatagaag tgcgttatgc agaaacagat caaatgggga ttgtctatca cgcaaattat 1930861 cttgtgtgga tggaggtcgg cagaacggcc ttgattaagg acttaggctt tttatatagt 1930921 gatatggaaa aaaaaggcgt tctgtcccca gtcgttgata tcaatatttc ctataaaaag 1930981 ccgcttcatt acggagaaac cgcggttgta catacatgga tagaggacta taacggattt 1931041 aaaaccgtct atggttacca catttataat ccggccggtg agctttccat caaagccacc 1931101 tcatctcata tttgtgtgga taaagaaagc tttaagccaa ttcaattccg caaagctttt 1931161 cctgattggc acacagcata tgaaaaggcc aaaaaatagg gaagtgaacg ggatatggcg 1931221 tttggtgtga aacgggagga acttaaccgg tggaaacaag cagtgaaaag aggagaaatc 1931281 gcatttttaa cacattactg gctggatgac cgatttccag aagcaaagac cgtgacaaaa 1931341 gccggctgtg cagacattga taagctggtt cagtggggag cggcgtacgg gttaaaaaaa 1931401 gaatggatcc ataagaaaag tgaatttccc cactttgatc tgctggggga aacacaaaaa 1931461 tatattttgg aacaagaaaa cctaaccgat catcttatac gatttcattt gtaaaaaaag 1931521 aacgcacatg aagtgcgttc ttttttattg gtattcaaaa accggttcat cagcgtcttc 1931581 tgaatagctg acgagaaggt cgtggttatc aaagtaccat aaatcacttt cttcaataaa 1931641 gaaggtaatg ccatcagctt ctgcagtgac tccagcctct tgtggggcat ctttcgctac 1931701 accgagagaa aaaccctttt gaacgttgct gcagcctcca tagcggacga aaaagcgaac 1931761 ctggtctccg ctttccaaat cgagttcttc tttataccag ttcaatgcgt cttcgttaat 1931821 tgtcatattc ataacagaac acccctttgt tcttcatttg aattttctct attataaacg 1931881 tattaggcta ttctgtgtca aaagagaagt tttttaagct tataaccatt ttactttagg 1931941 ttctgtttta ttgataattc gtttaatgtt cgctcggtgt ctgtatatca caaaaatagt 1932001 gagcagggta acgacaatca ataaatacgt atcatggaca aagaaactat atataacagt 1932061 atagatccct gttaacatcg atgagagaga aacaaattta gtcaagtata aaaagatgaa 1932121 gaataccgca accatcgtga taaataacag gggtgcgtaa aatagcaaaa cgcctcctga 1932181 tgtcgccacg gctttaccgc ctttaaattt ggcgaagatg ggaaacacgt ggcctaaaac 1932241 cgcaaagact cctgcaagaa gcgggtgaat atcaacatgc atgagaaaag gcaatgcagt 1932301 tgccagtgtc cctttcaaaa tatctccggc tatgacgacc gaaccagctt ttacacccaa 1932361 tgtacggaat gcattggtag cgcctaagtt gccgcttccg tgctcccgaa tatcaattcc 1932421 tttggcaagc ttgcccacaa ttaagccaga tggaatgctg cctatcaagt aggccaaaat 1932481 aatcaataaa gcaattaaca tctacatttc tcctttttca aattcccttc tttttatttt 1932541 aacatgagat gtcatgatct gatgataagt ttttttgtaa agtttgctta caaatcaaat 1932601 caaacatgca tcatattttg atttctcctg ttttgatcgt gtaaaataag tgaaaaagga 1932661 gtgacacacg atgcaaaacc cttctaaagc ggaaattaaa gagattcttc aaagaagcaa 1932721 acgtatagcg gtagtagggc tttcagaccg tccggataga acgtcacata tggtttcaaa 1932781 agcaatgcag gacgcgggtt atgaaattat ccctgtgaac cctacaattg atgaggcgct 1932841 aggtgtcaaa gccgtttcat ctttaaaaga gatagacggt ccgattgaca tcgtaaatgt 1932901 attccggcgc tcagaacagc ttcctggagt ggcggaagag tttttagaga cagatgcgcc 1932961 agtattttgg gcacagcaag ggctagttaa tgaggaagca taccagatgc taaaagaaaa 1933021 aggcagaacg gttatcatgg atctgtgcat aaaagtggca cacgctgtaa caaaataggt 1933081 gcagaactgc aaaaatcctt gtaaattcaa ggatttttgc tttttaattt taagatattg 1933141 tttgcgtatt acggtgaaac agatacaata aagcttgaac agcttttttt gaataccttg 1933201 tccagctggg tttcggccgt tcgatttgcg aaggtctgct gctttatata taataaacaa 1933261 acatacgttc tcatagtgta aaaacagcac tagccgatgt tttgagaaga actgattcgt 1933321 tagctctatg ttgcgattgc aaacatattg gttataatga ggagtccaag gcagtactgg 1933381 ctcgaggcga ggtttataaa aaatatctta tatacaaatg atgtgtaaca ctgaaaagag 1933441 aaagacaatg ttagtttttg aaaggggttt gtacgtttgg ctagaaaaca gcaatttgat 1933501 tacaacgaag atgccataca ggtgctcgaa ggccttgagg ctgtcaggaa aaggccgggt 1933561 atgtatattg gctctactga cgcgcggggt ttgcaccact tggtttatga aattgtagat 1933621 aactctgtcg acgaggtgct tgccggccat ggagatcaca taatcgtcaa aatacataaa 1933681 gacaatagta tttctgtaca ggatagaggc cgcggcatgc cgaccggaat gcataagctc 1933741 ggcaaaccaa cccctgaagt gattttaacg gtgcttcatg ccggagggaa attcggccaa 1933801 ggcggctata agacaagcgg cgggctccac ggagttggtg catcagtcgt gaatgcttta 1933861 tctgaatggc tgacggttac cattgagcgg gacggttttg tctatcagca gcgatttgaa 1933921 aatggaggaa aaccggttac atctctcgaa aagatcggca aaacaaaaaa gacgggaact 1933981 cttacacact ttaagccaga tccaacgatg ttcagcacaa ccacttataa ttttgaaacg 1934041 ctctctgagc gcttaagaga gtctgcgttt ttgttaaaag gactgaaaat tgagctgatt 1934101 gatgaacgca atgaccagcg tgaggtcttt tattatgaaa acggcataga agcgtttgtt 1934161 gcttacttaa atgaagaaaa agacgtcttg tctgaagtgg tctcgtttga gggtgagcat 1934221 cattctatag aagtggactt tgcgttccag tttaacgatg gttattctga aaatattttg 1934281 tcgtttgtca acaatgtcag aacaaaagac ggcgggacgc atgagtcagg tgcaaaaact 1934341 gcgatgacgc gtgcttttaa tgaatatgcg cgaaaagtgg ctttgctgaa agaaaaggat 1934401 aagaaccttg aaggcaccga tataagggaa gggctttcag ccattatttc tgtccgcatt 1934461 cctgaggagc ttcttcaatt tgagggacaa acaaaaggaa agctcggtac cagtgaagca 1934521 agatcagcgg tggatgcgat tgtttcagag cagcttgctt actttttaga ggaaaatcgg 1934581 gacaccgcaa cgcttcttgt caaaaaagca atcaaggcga gccaggcgcg cgaagcggca 1934641 cgcaaagccc gtgaagaagc aagaagcggc aaaaaacgaa aaaaatcaga agcgacttta 1934701 agcggaaagc tgacgcctgc gggttcaaga aacccggcaa aaaatgaatt gtatctcgtt 1934761 gagggagatt cagcaggcgg gtcagccaag cagggacgag accgcagatt ccaggcggtt 1934821 ctgcctttac gcggtaaagt cattaataca gaaaaagcta agcttgctga tatctttaaa 1934881 aatgaagaga tcaatacgat cattcatgcg atcggcgggg gagtcggggc agatttctca 1934941 atcgatgaca tcaactacga caaaatcatc attatgaccg atgccgatac tgacggcgcc 1935001 catattcaag tgctgcttct tacctttttc tatcgctata tgaaaccgct cattgagcat 1935061 ggcaaggtgt tcattgcgct gccaccttta tataaggtca gtaaaggaag cgggaaaaag 1935121 gaaatcattg aatatgcatg gtctgatgaa gagatggggg atgtcctgaa aaaagtcggc 1935181 aaaggctata ccattcaacg atataagggt cttggagaga tgaacgcaga ccagctgtgg 1935241 gaaacgacga tgaatccgga gtcccgcaca cttgttaggg tcaaaattga cgatgcggca 1935301 cgtgtagaga gacgtgtgac gacgttaatg ggagacaaag tagagccgcg cagaaagtgg 1935361 attgagaaaa acgtcgcttt cggcttagat gaagaaagca atattttaga aaatgaaaac 1935421 ttatcggtcg ctgaggaggt ttaatgattg tcacagccag aattatttca tgatttacca 1935481 ttagaagagg tgatcggcga ccgttttgga cgctacagta aatatattat tcaagacagg 1935541 gcgctgcccg atgcgagaga cggattaaag ccggtacagc gcagaattct gtatgcaatg 1935601 catacagatg gaaacacgtt tgataaaaac ttcagaaaag cggccaaaac ggtcggtaac 1935661 gtcatcggta actatcatcc gcacggtgac agctcggttt atgaagcaat ggtgcggatg 1935721 agccaggatt ggaaagttcg taatgtgtta atcgaaatgc atggaaacaa tggaagcatc 1935781 gacggagatc ccccggcagc catgcgttat acagaggcac gattatctcc gatagcatct 1935841 gagcttcttc gggatattga caaaaacacg gttgaatttg tgccgaactt cgatgataca 1935901 agcaaggagc ctgtcgtact cccggcgatg tttcctaacc tattggtcaa cggatctacc 1935961 gggatttcag caggatacgc gaccgacatt ccccctcatc atctgggaga agtcattgat 1936021 gctgtcatta agcgtattca aatgccttct tgctctgttg acgaactcat ggaagttatt 1936081 aaagggcctg attttccgac aggcggtatt attcagggcg ttgacgggat aagaaaagct 1936141 tacgaaaccg gaaaaggaaa aatcattatc cgcggaaagg ctgaaattga aacaatcaga 1936201 ggcggacgag aacaaattgt cattactgaa attccatttg aagtaaataa agcaaacctt 1936261 gtaaaaaaaa tggacgagtt ccgtattgat aaaaaggttg aaggcatctc agaggttcgt 1936321 gatgaaacgg atcgaacagg gctgagagtg gtcattgaac tgaaaaaaga agctgatgcc 1936381 aaaggcattt tgaatttctt atataaaaat actgatttgc agatcacata taacttcaat 1936441 atggtggcta tccataaccg ccgtccgatg ctgatgagcc tgccgtctat tttggatgca 1936501 tatatcggac accaaaagga agttgtcaca aaccggtccg tttacgagct tcaaaaagca 1936561 aaagacagac atcatatcgt agaagggctc atgaaagctt tgtctatttt ggatgaagtg 1936621 attgcaacaa tccgttcttc tagcgataaa cgtgacgcta aaaacaattt gatcgcgaaa 1936681 tatgaattta cagagcctca ggctgaagcc atcgtgtcat tgcagctata tcgtttaacc 1936741 aataccgata tcacagcgct taaggaagag gcagaagagc tcggtaaaaa aattgaagag 1936801 ctcgaatcta ttctgagcaa tgataaaaaa ctgctaaaag tgattacaaa cagcttaaaa 1936861 gcactgaaaa agaaatatgc agatacgaga cgctccgtga ttgaagaaaa aattgaagaa 1936921 attaaaatca atctcgaagt catggttgca tctgaggatg tatatgtaac cgttacgaag 1936981 gatggttacc taaaacggac gagccagcgc tcatttgccg cttccaacgg tcaggacttc 1937041 ggaatgaaag atacggacag gatgctgcat cagtttgaaa tgaatacgac agacgtgctg 1937101 ctgctcttta cgaacaaagg aagctacatc tattgtcctg ttcaccagct gcctgatatc 1937161 agatggaagg acatgggcca gcatttttca aatctaatca ctattgaccg tgatgaaacg 1937221 attgtaaagg ctataccgat aaaagaattt gatccgtcgg catatcttct attctttacg 1937281 aaaaacggta tggtgaaaaa gacagagctc actcattata aagcacagcg ttattctaag 1937341 gcacttgtag ccttaaatct gaagggtgaa gatgaactga ttgatgtaca tgtaacaaat 1937401 ggggaaagcc agatctttat ggccactcac ttagggtatg gtctatggtt tggagaagac 1937461 gaagtgaatg tagttggcgc gcgtgcggca ggtgtcaaag ggattaactt aaaagaggat 1937521 gactttgttg tctccggtga gattcttcag caatctgatt caattgtctt gttcacacag 1937581 cggggagcgg ttaaacgcat gagtctttct gagttcgaga agacatcccg tgcaaaacgc 1937641 ggtgtcgtaa tgctaaggga actgaaaaag aatcctcacc gtgttgtagc actgttcgct 1937701 tgcggtcttg aacagcgact aatggcagaa acagaaaaag gcgacagaaa agaactgcag 1937761 acaaaagagt tgcggacaaa cgacagatac agcaatggct ctttcttttt tgatgaagag 1937821 gaatcaggca aggttacagc tgtttggcgc cttcatacag aacaataata aaaaacccgc 1937881 tcatactata tgagcgggtt tcgtttgttt tttatcagct ttcatggttg gtgaatagat 1937941 ctgttacagc atgaatgact tcaatcccct gccatacaaa taaattcagc gctgtgaaag 1938001 aaaataagcc taaaatcacc attcttaaga taaacaacat gtttaacagc ctcctcatat 1938061 tttcgttaca taatcgggtg atgttgaaca tgaagtttgc cgaaataaga cgattgataa 1938121 aatttggcca gtataaagct ttttttccgc tgacgtctgc gggagtatcc cgtacttttg 1938181 ctttcagcgg tcagcagcag aacagccatt gcccataaag cggtcagcgt aaatgcccct 1938241 gtgatggatt tcttctcatc atcagcattt tggccggctt tcatctcatg catttcctgc 1938301 tggtcggcta cggctttata atgatggccg atatcaaagg cgtggggaat tgagaacaaa 1938361 tgaaaactgg caatcgccaa gaataagatg gatgctttca atatcgttac ttttttcaaa 1938421 tgatctcccc ctcctttaat attactgaat atttttataa taatacccca atccatccta 1938481 aaagtaaacc tgatttatta aatttaaaaa taaatttaac tttgttaagt atatatcttt 1938541 ttgcttattt ttgaaagaga aaacttcttt tattagcgta tgtatacccg gtttatggtg 1938601 tgaataaaaa catattttaa atgatatgtt gtttaggatt tattacttta tttatgtgta 1938661 aatcaaagag aaaggcaaga gaatgggaag aaatgattac attgttaata gggtactctt 1938721 tttttaaagc cagtttgcaa ggaatgtttt tattcgtagg aaaataatag agaaggggtc 1938781 gacagagtaa catctggcta tgacaatatt cttctcgaaa aaacttccta attcgtcata 1938841 ttgtgatata ataaaactcg ttatgttaaa aaatctaaca tcaaaatcga attcgtattg 1938901 aattgatgaa aacgggaggt aaatatggag tcttttttca atagtttgat taatattcca 1938961 agtgatttca tctggaaata cctattttat attttaatag ggcttggatt attttttacc 1939021 atacgttttg gttttatcca attccgttat tttattgaaa tgttcagaat agtaggggag 1939081 aagccggaag gaaataaagg tgtttcatct atgcaggcat tctttatttc ggccgcatcc 1939141 cgagtcggca cagggaattt gactggtgta gccttagcaa ttgcgacagg cggaccaggc 1939201 gctgtatttt ggatgtgggt agtggctgca gtaggcatgg cttcaagctt tgtcgaaagt 1939261 acattagcac agctttataa ggtaagagac ggggaggatt tccgcggagg gccggcctac 1939321 tatattcaaa agggtcttgg tgccagatgg cttggcatcg tttttgcaat cttaattacc 1939381 gtctcattcg gcttgatttt taacgctgtt caaacaaata caattgctgg agcattggat 1939441 ggcgcattcc atgtaaataa aatagttgta gccatagttc tggcggtttt aactgcgttt 1939501 atcattttcg gcggtttaaa acgtgttgtc gctgtttcac agctaattgt gccggttatg 1939561 gcaggcattt atattcttat cgctttattt gttgtcatca cgaatattac ggctttccct 1939621 ggcgttatcg ctacaattgt taaaaatgct ttaggttttg aacaagtcgt cggcggcgga 1939681 ataggcggca tcatcgttat cggtgcgcaa cgcggacttt tttcaaacga agcaggaatg 1939741 gggagcgcac caaacgcggc tgcgacggct catgtatccc atccggcaaa gcaaggcttt 1939801 attcaaacat taggcgtatt tttcgataca tttatcatat gtacgtccac agcatttatt 1939861 attttgctgt acagtgtaac gccaaaaggc gacggcatcc aagtcacaca ggctgctctt 1939921 aaccatcaca ttggaggctg ggcgccgact ttcatcgcag tcgcaatgtt cttgtttgca 1939981 ttcagttcag ttgtcggcaa ctattattat ggcgagacaa acattgaatt tattaaaaca 1940041 agcaaaacat ggctgaacat ttaccgtatc gctgttattg ctatggttgt gtatggatct 1940101 ttatcaggct tccaaatcgt ttgggatatg gcggacctct ttatgggtat catggcgctg 1940161 atcaacttaa ttgtgattgc gctgctgtca aacgttgctt acaaagtgta taaagattac 1940221 gcgaaacagc gtaagcaagg acttgatcct gtgtttaaag cgaaaaacat cccagggctg 1940281 aaaaacgctg aaacatggga agatgagaaa caagaagcat aatataaata taaaacaaag 1940341 ctgcattcaa tagttgaatg cagctttttc attattggaa ataaatttaa tttttcgact 1940401 cgaatgaaaa atgacgtgta aagtcccaat tcagtccagt tttctttgtt ctatatgtgt 1940461 catgtgtgtc ttattcattg gaggtagagc aaattgacag gcttttaaac ctccccaaaa 1940521 caagaaatta ggttgataga caatcatgag aaagattttt acaatgagtt cgtgctcata 1940581 agaagtgtag agccaaaatg atgcgaagga ggaaaagatc agatatgaaa cggtcaatct 1940641 ctatttttat tacgtgttta ttgattacgt tattgacaat gggcggcatg atagcttcgc 1940701 cggcatcagc agcagggaca aaaacgccag tagccaagaa tggccagctt agcataaaag 1940761 gtacacagct cgttaaccga gacggtaaag cggtacagct gaaggggatc agttcacacg 1940821 gattgcaatg gtatggagaa tatgtcaata aagacagctt aaaatggctg agagatgatt 1940881 ggggtatcac cgttttccgt gcagcgatgt atacggcaga tggcggttat attgacaacc 1940941 cgtccgtgaa aaataaagta aaagaagcgg ttgaagcggc aaaagagctt gggatatatg 1941001 tcatcattga ctggcatatc ttaaatgacg gtaatccaaa ccaaaataaa gagaaggcaa 1941061 aagaattctt caaggaaatg tcaagccttt acggaaacac gccaaacgtc atttatgaaa 1941121 ttgcaaacga accaaacggt gatgtgaact ggaagcgtga tattaaacca tatgcggaag 1941181 aagtgatttc agttatccgc aaaaatgatc cagacaacat catcattgtc ggaaccggta 1941241 catggagcca ggatgtgaat gatgctgccg atgaccagct aaaagatgca aacgttatgt 1941301 acgcacttca tttttatgcc ggcacacacg gccaattttt acgggataaa gcaaactatg 1941361 cactcagcaa aggagcacct atttttgtga cagagtgggg aacaagcgac gcgtctggca 1941421 atggcggtgt attccttgat caatcgaggg aatggctgaa atatctcgac agcaagacca 1941481 ttagctgggt gaactggaat ctttctgata agcaggaatc atcctcagct ttaaagccgg 1941541 gggcatctaa aacaggcggc tggcggttgt cagatttatc tgcttcagga acattcgtta 1941601 gagaaaacat tctcggcacc aaagattcga cgaaggacat tcctgaaacg ccatcaaaag 1941661 ataaacccac acaggaaaat ggtatttctg tacagtacag agcaggggat gggagtatga 1941721 acagcaacca aatccgtccg cagcttcaaa taaaaaataa cggcaatacc acggttgatt 1941781 taaaagatgt cactgcccgt tactggtata aagcgaaaaa caaaggccaa aactttgact 1941841 gtgactacgc gcagattgga tgcggcaatg tgacacacaa gtttgtgacg ttgcataaac 1941901 caaagcaagg tgcagatacc tatctggaac ttggatttaa aaacggaacg ttggcaccgg 1941961 gagcaagcac agggaatatt cagctccgtc ttcacaatga tgactggagc aattatgcac 1942021 aaagcggcga ttattccttt ttcaaatcaa atacgtttaa aacaacgaaa aaaatcacat 1942081 tatatgatca aggaaaactg atttggggaa cagaaccaaa ttagttaagc ttttttttgg 1942141 cggacatcag taacgatgtc cgtttttatc atctaatagg aggtttgcgt tgtggatgaa 1942201 atactgaaac agtatatggt gctgtataaa aaaatgagta atatgataaa tggtcccgac 1942261 tatccaggta aggaaaaaga catccagcat caaaaagatc agatcgaagt ttacgaaaaa 1942321 cagctgcagc aaggattttc tacagattat gactatgatg tgtttgctga ttctgttatc 1942381 aaatgcgcat atggcgatat gacgctggaa gatttagaag ccgtttatta tggattgaca 1942441 acaccatttt tttgatttgt cattcagcag taaaatttca atttctgtct cactaactta 1942501 agtatacttt gatattgaga cagaaattta tttattttgt ttacttccta gaatatatat 1942561 tatgtaaact agaaaagatg aagaataaag ctttgctgtt tttatgtaca tcctttcttc 1942621 ttcctgtaat tcagcaacaa aataaaaaag cgatttccca atcggaaaat cgccaattca 1942681 gacactctat tatttatgtg tgtctttgtg ctcttaacga tttacaacaa atgttgtcac 1942741 gctttgagct ggaagatgag cccaaaaatg attgcctgat acagtgagat tcgttccagg 1942801 ttgtagattg ctgctgctgc tcgtgatcca tctagatacg tttgaagcag atccattctg 1942861 caaaacaaag ttttggttga ctcctgtgtt gcttttattg atggcaacaa taacgacctt 1942921 gttgtcacct ttataggctg acacgtaaac gttcgcatta gggtttttcg ttgcatcaat 1942981 ccttacatag ccgggacgca caaactttga gaaatgagcc atattgtagc cgcgtttgct 1943041 gatcgtacca tcttctttca taggtccata tgatcttcgg atgtaccacc atacataagc 1943101 ttgaaagtcc ccctctacca tcgcattgtg aatatgctgt gaaacatcca atgcctcagg 1943161 ccatcgatcc gccgagttgg tatcactgtt tggatagtat acttccgtca tccaaaggtc 1943221 cttccccgct cctttttgtt tgaaaagagg ataagggaat tggctgacct gggtgccgta 1943281 caggtgagtt ccgagaatat ccatattggc aagagcctgc ggatcgttca agatcgggtc 1943341 cgacaaattc ttcaagtatt gaaatgactc aggcgcaatg acgcgggcat tgatcgagcc 1943401 ggcgttttct ctcataaagc gaagtatttc ttgcggcgtc caccacgtcc actcgtgagc 1943461 gtaatcaggc tcgttttgga ccgaaatcgc gtaaagattc acaccattat tcttcatgaa 1943521 ggtaacaaaa tcgttaagat gctgcgcgta tgctgcgtac ttgttgtatt tcagccgttt 1943581 agccgatgtg tcaccattcc gattaaaggt ctcaaccata tcacttggag gattccaagg 1943641 agaagcaaaa acgattgctc cgtgtttgac cgcactcttt gcagtctcca cctctttata 1943701 ccaattattt cgattttcat ctacatgaat tcttaagatt gaaaatccta actggttctg 1943761 tccattgcca aaagcagttt ctctttgagc tgctgtaaga tccccagccc aagccggatg 1943821 attcatccct ccaaaaccgc gaatcacttg tttctctgca gatacattaa ctgttacatc 1943881 acttgctgcc aaaacttcag tagcgcctgg ccctaacatg actgacagca tagtgaaaca 1943941 tactaatagt acacaaattg ttttttttat gcgtggaatc atttattcct ctccttcgtc 1944001 atgtgtcttt tacggtatta aaaaatctgc atggcatatc cataatggcg ggctgttccg 1944061 gtgctggccc gtacttcacc cgcctcgttt ttaagcggtc ccattacgag tactatcttt 1944121 gcgtaaactg ccagtaatca aaattaaaca agtttcctgt acctgttccg gtaaatacaa 1944181 agaatacttt gtgcacaccg gttgccccgc ttaccgcagt ttctatttcc ctccacgttt 1944241 gcgctccgcc tgttgaaggc acattcagag ttccaacaag cttaccgtct gcactgtcga 1944301 ggcgcacttc tattttcccg cctaaagtgg atgctacatt tgctttaaat gacctggcac 1944361 cgcccgctcc gaagtctgca tttcctacag caatccagtc tccattttga atgcttgtta 1944421 catgctgatt atttactggc ccgccgggtg ctgtggactt ctctgtcaaa atgcgtccat 1944481 tccaagcaaa cgtttcagct tctacccggt tatatgggtt taaattggaa atttgtgtta 1944541 cacctgcata atttgccgct acctcttgaa tagatccatc tgcattatgc accagcttat 1944601 taatatgggg agagcggtat cctttgccgg ccccgaacag agcggaactg acagtttgcg 1944661 catggtacac cacataccac tcgtttttaa aattgaaaac agcatgatgg ttgtttccgc 1944721 cacctccgaa aaatgcaccc ggatttttca ggaagtgccc tctatatgta aagggaccca 1944781 tgggacttga actggtcatg tagccgatct cacccggggg tttatcggcc gggtgcgtgc 1944841 cgccgaaatt gatgcaatag gagtaataat atgttccgtt atacttgtgc aatcccgaat 1944901 cttcaaacat gaaaggcgca tcaattgtag atgcacttcc aacaacactc gtcatatcag 1944961 gccccaattt tatgactcta gccgttttag gattggccca ttgtccctgc gttggatttg 1945021 aaacgccagg aacgcctccg ccggcataca ggtaaccggt tccgtcgtca tctacaaata 1945081 ctgccggatc aaaaagccat acaacaccag acattcctgg cgtacttggc gttacgagcg 1945141 gttttccgat tgggtcggtc catggaccaa tcgggctgtc tgcggtgaga accccgatac 1945201 ctccgccgct gtttgcgaaa taaaggaaga atttatcctt gccattaatt tttttaactg 1945261 cgattgacgg tgcccatgac gcacctgccc attttgcaat tccacggcct ccattagctc 1945321 cattggcacc tgctaccgga atggctccgt ggtctgtcca gttcaccata tccgctgaag 1945381 atatgacgaa tactctattc aaattggcaa atgaattatc tttaattgtt ccgttgctat 1945441 tatattcata gtcatcactt gacatataga tgtagactct tccgttatag gtcagcgcaa 1945501 ccggatccgc tcccaaatga tggtcgataa gcggatttga attccctata tgttttgcaa 1945561 ttgtagtact agtggcagca tacgcagact tcccagataa gcagctcaat aataaaacta 1945621 gaatccataa acatacgcta cactttttcc tcatcacttc acatcctcct ttttccttaa 1945681 aatgggggat tttcttttgg aatttgataa caacaggtca cgaagattgc acgcataaag 1945741 tagccggaag ctgtttagca atgttcccag ttgttctgaa agctcatctt catgtgtctc 1945801 cattctctct tttcttcgag gagatcgcac cactccttca aaattgttca aaaaaacttc 1945861 cccattccta gcgaccattg tccagaaaat aaaaagacag gattgttcat ggcctcccac 1945921 taatcacatt gaacggagat tacatcatta tccaagatat ccctttatct aacatcctac 1945981 atcattaaaa aaattgtgta tagaaacttt tggaggagtt agtgttcgat tctacaaagg 1946041 aactggatac atttattcat tgataagatg gggctaacac tccgtttata tttgtatgtt 1946101 ttcagacaca aaaaacagcc gttcaatgcg gctgtttttt tcaagagtat aagactattg 1946161 agcggtatac ccgctttttc atgttttgtt catattttat taattgttta ttcaacactg 1946221 tccgctatag taatccatat caacaaatat gactgccact cgcatctttt atgaagggag 1946281 gttcgttacg ctgaaagaaa aaataaagac attaggccgt ttttgcaccg taggcgtcgg 1946341 caatacgctg atagattttg gtgtcttctt tcttcttacc gcttgtcatg tctcttatct 1946401 gccggcgcag atctgctcct atactgcagg tatcgtcaac agctatgtgt ggaaccggaa 1946461 ttggacgttt tgtgtgaaac gtaaggctga cgggaaagag atcgtgcgtt ttctcatgat 1946521 taatattgcc gcgtcaggga tcaccttttt gctgctttat ttgtttcaaa attgcggctg 1946581 ctcgcttttg gtgagtaagc tcgccgccac tatcggcgga atgatgatga attttatcgg 1946641 aaaccgaatc tgggtatttg gagattcgct gaaaaacata caggatcagg agtgaagatg 1946701 aatgagaaaa aaagtgagaa aagcggttat acccgcagcg ggtttaggaa cgagatttct 1946761 gccggcgaca aaggcgcagc ctaaagaaat gcttccaatc gtcgacaaac cagcaatcca 1946821 atatattgta gaagaggccg cagagtcagg aattgaagat atactgatta ttacagggag 1946881 aaacaaacgc tcgattgaag atcattttga tcggtcggcg gaattggaat tcaatctccg 1946941 ggaaaaaggc aagacggaga cacttaagga aatgcagcag attgccgatt tggccaacat 1947001 tcattacatc cgccagaaag aaccgctcgg attaggccat gcggtgctgt gtgcggagca 1947061 ttttatcgga gatgagcctt ttgctgttct cttaggtgat gatattatgg tgtctgaaac 1947121 accggctctt cggcaattaa tggatgtata tgacgtttat ggcacagagg ttgtcggtgt 1947181 acagtcagtt ctccctgagg atgtcagcaa atatggtatt ataaatacat cagggtctca 1947241 agggcatgta tatgaagtga acgatttagt ggaaaagcct tctcctgaag aagcaccttc 1947301 ggaaatcgca gtaatgggac gttatgtgct gaattcttcg atcttctccg ttttgaagac 1947361 aattggcaga ggcgcgggca acgaaattca gctgacagat gcgcttcgtg aggtttgccg 1947421 taaggagccg atccatgccc ggctgctgga aggaaatcga tatgacattg gcgataagct 1947481 gggctgtttt aaagcgagca ccgaaatcgg cttaatgcgt cccgaaatga gatctcagct 1947541 tttggcctat ttagaagatg tgatcaaacg ggaaacgaaa gaaatgctgc ggtaaaaaaa 1947601 ttgtaaccat cttgctcgtc aatcagtcat ataatagtga aaaagattag gacaggttgt 1947661 gaagaatgtg ggcagtttga taagcgaaat tttaacatgg ctgacgaaca tgggatatgc 1947721 gggtattgcg attgggttaa tgattgaaat cattccgagt gagattgtat tagcttatgg 1947781 cggctatatg gtatcggagg gcacgattgg atttattggc gcaattattg cgggtgttat 1947841 cgggggcacc attgcccaga tctttattta ctggatcggt cgctatggcg gcaggccatt 1947901 tctggacaaa tacgggaagt atttattgat taaaaagcat catatcgata tgtcggaaaa 1947961 ctggtttcag aaatacggcg ccggagttgt cttctcggct cgttttatac cggttgtcag 1948021 acatgccata tccattccgg caggtattgc cagaatgcct tttctcaaat ttgtggtact 1948081 gactgtgctt gctatcattc catggtctat cctgtttgtt tatttaggca tacagctagg 1948141 aagccagtgg gatgatgttg agaatatagc aggcacttat acaacaccga ttatgatatt 1948201 ggctgttgtc gtgatagccc tttattttgt gattaagaaa cgtacagcca tatttaaacg 1948261 atagctagcg gatatgcata ggggtgactg acgctcccct atgcatattt ttttacttgc 1948321 gatgttgatt tgccagcttc agattctccg ctaaaaatgc gacaaacact tcatcccgca 1948381 cgagcgatgc ggcataattt ctcttaataa accattctgc ctcttcaaac gctgcgaatg 1948441 tttcgtcttg ggtttctccg ttaatttgaa tattccattc gttgtctaaa gggaaaagaa 1948501 aaaatctcat ttgtgcgcga ttttcatata atgatccatt cgcagatccc tttagattat 1948561 agatgttacg gaaggcatcc ggccgtacag gatcaatacg gaaagcttca gctacaaaca 1948621 actcgtatac ttcatcggtt attgaacagc cggacgcttt tgcatgccct ccgccgccat 1948681 atcggccggc gatttctgac acatcgatgt aatcatgaat ggtgcggaga ctgactcgtt 1948741 ttgaccccat gctcaaaatc gcaatgtaat cgaggtgcgg gttatctttc cctagcctgt 1948801 tccccagctc tgaatggtac gattcagcgt gaacgatgcc tacacagtgt tcgtgaacaa 1948861 aggtttgtac catttccctt ttctttctgc ggaggtagcg ctcgattttt tcgtcttcta 1948921 aatcaagcag tttttcttca aaatcatcga agaaaaattc gtcatgcgtg gaaaggcgct 1948981 ggatcatttt tgcttcaaat tcatcgattg acagcaaaaa gaaaagatca ttaagccgct 1949041 tcgcctgttt ttgatcgtac cgctcccact cccatgtatc gtattggcgg acgagctctg 1949101 tgaattgatc taaggcgttt gtcggtttca tgaagccatt ttcaatgaga tagccatata 1949161 aaagcgatgt cgcggatgtg agccttccat catcgtattc cacctggaca aatccccatt 1949221 catgctcatt caaatgaagg gctgttttat gatggtcaat gagcttcact ttgccccctg 1949281 catgaacata ctcattcaat ctctcttcgt tttcttcatt gacggcgaga tcggtgatga 1949341 ataacgcgtc ctgtctgttg ctctccttcg ctttttctaa aaagtactgc acctgtgcgt 1949401 ttaagccgtt gacagagtta taccggatct ctacgtcttt tccgaacgcc aattttgcta 1949461 cgattccgca tcctactccg tccaagtcgt tatgtgaata taaatgatac ataatgtagg 1949521 ccccttttta tgataaactg acaattgccg ctagaggtgc ggcagccttt atttactatt 1949581 ctaaaaaacc aagcgtttta tgcaatggta attagttgac ataatgttgt tattgtaaat 1949641 atataaagga gcgctttttt tgcgctccta agttcttgct tttacaccgg ataaaccgga 1949701 tgctttcgat tggtaaatgt catttccttt gtcatgtatg ccttgagccg tttggccagc 1949761 tcatcacgca gcgaattggc tgggataaca gcatcaatga tcatttctga agccagacgg 1949821 tagatattga tgtcctcttt gtattcctcc cgtttgctgc tgataaatgc ggctctctct 1949881 tcttctggca gctcggcgat ttttttagcg tagacagcgt ttacagcggc ctcagggccc 1949941 atgacggcga tttgggcggt tgggagcgct agacagcaat ccggttcaaa tgccggccct 1950001 gccattgcat acaaccccgc cccgtaagct tttcggacaa tgacagagag ttttggaaca 1950061 gttgcctccg acatcgcaga aatcattttc gctccgtgtc tgataatccc agcctgttct 1950121 acttttgtgc caatcataaa accggggata tcggctaaga acagcaatgg gatatgaaaa 1950181 gcgtcacata aggtaataaa cttagccgct ttgtctgctg aatcgtggaa taagacgcct 1950241 ccttttacct tcggctggtt tgcaacaatg ccgacaggct gtccgtggat tcgtgcgagg 1950301 cccgtcaata attccggtgc aaataaggct ttgatctcaa aaaatgagtc ttcatctatg 1950361 acccgctcaa tgagctcatg catatcaaaa ggtgcgtttt gattttgcgg aatgacgtcg 1950421 gcaagcggag tttcgaagtg ttttggcggg cgtttctcat gaatgggcgc tttttcttga 1950481 aaatttgccg gaaagtaaga caaataagcc cgcaccagct gtatggcttc ttcttcagtt 1950541 tctgcaagaa tatctccgca gccggagatt gagcaatgca tacgggcgcc acccatttct 1950601 tcgagagaca ctttttctcc aataaccatt tccgccatcc ttggcgaacc taaatacatg 1950661 gaggcgttac cgtctaccat aacgacgata tcacagaagg ccggaatata agcgcctcct 1950721 gccgcagatg gtccgaaaag cagacagatt tgcggaatgc gtcccgataa tttgacttga 1950781 ttgtaaaaaa ttcttcctgc accgcgtctc cctggaaaga cattgatttg gtcggtaatt 1950841 cgggcgcctg ccgaatcgac taaataaatg agcggacagt ttaatttttc ggcgatttct 1950901 tgaattctga tgattttttc aactgttttt gctccccatg accccgcttt cactgttgaa 1950961 tcattcgcca tgacgcaaac ggtttggccg ccgattttgc cgatagcggt tacaactccg 1951021 tcagcgggaa gcccgtctga catacattcc gcaaaaaaag cgtcttctag ctcaatgtca 1951081 tcgtcaaaga gaagggaaag ccgctctctg acaaagagct tgcctttttc ccgattgctt 1951141 tgatgatact tttccgctcc gccttttcga atccgttcag cccgttctgt tcgttccttt 1951201 tcataatcca tcagcattgc ctccctttta tattcccttg tatacggccc gtcttttttc 1951261 ttgaaaggcc tgaagccctt ctctcctgtc ttttgtcggg atggtttgtt catacgcttt 1951321 ttgttcaatc gcaaggcctg tagcaagatc tgtctccaat cctttattga ttgcaaattt 1951381 agcctgacgg acagcgatcg gtccgttggc agaaatggct gcggccagtt cctctgcttt 1951441 tggcataagg tcacaaggag ccgtgacatg ctctacaagg ccgatttctt ttgcttcgtg 1951501 tgcggtcacg cgtctgcctg tataaatgaa ttcttttgct tttcctctgc caatcagccg 1951561 gggcagcctt tgggtccctc cagcgcccgg gataatagct aaccctgttt ccggaagtcc 1951621 cagcacagct gcttcagttg cgattcgaag gtcgcatgcc aatgccaatt ctagtccgcc 1951681 gcctaatgcg cttccattta tcgcagctat gaccggctgc ggcaaggcat caagtaaagc 1951741 cgccgttctt tgaatgagag atacactttc cagaacctga tcttctttca gttttatccg 1951801 ttccttcagg tctgcccctg cacaaaacgc tttttcaccg gtgcctgtga ggatgacgca 1951861 acggatgttt gagttaaatt caatttcctg gataatcatt tgcaggtttc taagcatttc 1951921 cgctgaaaga gcatttgctg cctgaggcct gtttaaggtg atcaacgcca tatgttcatt 1951981 tttaacagta aaaagaatag aatctcccat tgtatgcgtc ctccctttta tcaagatgat 1952041 ttaaacacct gtaaatttct gctcggcagc ggtttgccca ttttttcttc aatccatttg 1952101 gccgcagata gcagtttttc tagctttaca tttgttttga tatccatctg ttcaagcatg 1952161 tacacgatat cctcagttgc ggcgtttcct gatgaacctg gcgcatatgg gcatccccca 1952221 agcccgcctg ccgagccgtc gaacaccgtg atgcccattt ggagtgctgt gaccatgttg 1952281 gccagagcgg ttcctctcgt atcatgaaaa tgcagggcaa tttgattagc cgggaatcgt 1952341 gccaaaagag cttcaagtac agtttccact tgggcgggat tagctgctcc aatcgtatct 1952401 ccaagcgaca gttcagaaat cccaaattca aatagagctt ctgaaaggcg aatgacttgt 1952461 tcaatgggga catctttttc gtacggacag ccgaaaacag tcgagaggta ggctcttgtt 1952521 gtgaggtttg ctttttgtgc gtcgttgttt acttgtttga gtatatggag ggattcagaa 1952581 gtggatttat tgatgttttt tctgttgtgc gtctcgctgg cggacataaa aacgcaagcc 1952641 tcgttaatgc ctccttcaag tgcattctcc agtcctcttt gattcgggac aagtgccgcg 1952701 tacgttaccc ctttttctcg gtcgatgcct tttgctacat cgatagcatc tcgaagcgcc 1952761 ggaatccatt tcgggtgaac gaaggatgtg atttcaatat acgacagccc tgtccgggaa 1952821 agctggttga tccaggttat tttatcctct gttgcgatcc aaacgggctc gttttgtaag 1952881 ccatcacgcg ggccgacttc tttgattgtc acttttttag gatatggcat ggtcttcctc 1952941 caaattattg agtggaattg ctcagttcga gcagtacgtc tccttcattt acaaagtcgc 1953001 cttccttttt tttgacttct tttacgattc cgcttctatc tgcaacgatc gggatttcca 1953061 ttttcatcga ttccaaaatg gctacctcct ggcccttttc gatttggtcg ccggctttga 1953121 cgtggacttt ccacaggttt cctgccattt gtatgctaac cgtcatgaca actgcctcct 1953181 ttataggtgc tgtttcaaaa agtcagtcgt gacatcccct tctttaaatg cctttgttgc 1953241 cgcagcctgt atgaggagcg gaaggtttgt tttgattccc tctacacgat agtcgcgaag 1953301 cgctgtctct agtttttcaa ttgcttctgt tctggtttgg cctttgacaa tcatcttagc 1953361 gatcatcggg tcataaaaag gggtaacggt gctgtctttt gctaccgcac attcgtgtct 1953421 gactcctttt tggtcaggaa gtgaaaacgc agtgatcgta cctggtgacg ggaagaaggt 1953481 cttgggatct tccgcgtata ttcgaacctc tatcgcatgc ccgttccgtt ggatgtcttt 1953541 ttgggagaat gtgagtgtat ggcccgcagc aatccgcagc tgctgctcaa ctaagtccag 1953601 gcctgttatt tcttcagtca cggggtgttc aacttgcagt ctcgtattca tttcgaggaa 1953661 ataaaaattt tgtttctggt caactataaa ttcgatggtg cctgcgttcg tatagccgat 1953721 tgccttcgct gcttttaccg ctgtttgacc gatcttcatt cttagttcat cgtctacaaa 1953781 tggagacggt gcttcttcaa tgactttttg gtggcgcctc tgaacagagc aatcacgttc 1953841 aaacagatgt actgtatggc cgtgttgatc ggccaaaagc tgaacctcga tgtggcgcgc 1953901 atgttcaata actttttcta tatacataga cccgtcaccg aaaaaatctg ctgcgcgctt 1953961 tttgtttccc tcgtacgctt tttttaatgc ttcttcattt tcaacacgct gcattccgat 1954021 gccgcctccg cccgctgaag ctttcagcat gacaggatag ccgatttgac ttgcggtgcg 1954081 gcaggctgcc tctatatctc cgagggattc agaaacgccc ggcaccacag ggacacctgc 1954141 agcctccatt gcttttcgcg cttcaatttt gctgcccatc tttgcgatga tatcagggga 1954201 aggtccgata aacacgatgt tttcttgctt gcagcgttca gcgaaccggc tgttttctga 1954261 taacaatcca tatcccgggt ggatcgcgtc ggcttttgct tttttcgccg tctttatgat 1954321 tctctctata tttaaataac tttcactgac tctcgattcc ccgatcaaat atgcctctgt 1954381 agcggctttt gtatggggcg cgtccttgtc tgcttctgaa taaacagcga ccgttttaat 1954441 gccgagacgg ctgcatgttc ggataattct cattgcaatt tcaccgcggt tggcgatcag 1954501 tacttttgta aacatgattt cacctcattg acttgatgat aagttgaaca tttcaatcgt 1954561 tttttctcgc agtttatatt tttgaatttt gcctgaggcc gtcatcggat agtcatccgt 1954621 aaaaataaca taacgcggaa ttttgtggcg ggcgattttc cctttgcaat aggctttaag 1954681 ctcatcaggt gaaacgcttt taccgtcttt cagtttaatc caggctgcag cttcctcccc 1954741 gaatttggcg tcaggcacac caaccacctg tacatctaaa acagcgggat gctggtataa 1954801 aaattcttca atttcccgcg gataaatgtt ctcgccgcct ctgatgagca tatcttttaa 1954861 tcttccggtg atgcggcagt acccgtcttc atccatgaca gcaagatctc cggtaaacag 1954921 ccatccgtca tgattgattg cttttctggt cgcatctttg tctttataat agcctttcat 1954981 gacgtgatag ccacgggtgc acagttctcc ctgcatgcct ctttgaactt cttgacatgt 1955041 cccgggttct acaattttca cctcagtatg tggcagggca cggccggttg tttcgactct 1955101 tcttatgaag gaatcatttg ctctcgtttg tgtaatgact ggcgaggctt cggtttgtcc 1955161 ataggcgatc gtaatgtctt tcatgcccat cctttcaatc acagctttca tcacttcact 1955221 tggacaggga gagccggcca tgattcctgt tcggagcgtc gatagatcat atgcatcaaa 1955281 atccggatga tgcagctcgg cgataaacat ggtaggcaca ccatggagca ctgtgcattt 1955341 ctctttttct accgttttaa ggacggtaac gggatcaaat tcttgcacgg gtatcatggc 1955401 tgccccgacg gatacacatg ccaaaacccc aaggacgcat ccaaagcagt gaaaaaacgg 1955461 aacagggatg cacatgcggt cttgagaggt taaagccata cattcagcga tattagcagc 1955521 gttattgatg acattgaaat gggtcagcat cacgcctttt ggaaaccctg tcgttcctga 1955581 tgtgtattgc atattaatca cattgtcttt atccaggctg ttcattctct cttcaagctc 1955641 agcatctgtc actgttttcg ccaatatctc tgtatcgtcc caatgataca tgccagacaa 1955701 tcgtttattg ccaatataga tcagcgtttt taaaaaggga tagcgttcag atttcagttg 1955761 gccgggcttt gcttcttgca gttctggaat taaactgttc acgatgtctg gataagaagt 1955821 gcccctgtat gaatccatga taataagcgc cgcggcatcc gattgcttta acaagtaatc 1955881 aagctcatgt gcttgataat tggtattgac ggtcacgagc acggctccga tcttcgcagt 1955941 tgcgaactgg acggcaagcc attcagagat attagaagcc catatggcga cgtggtctcc 1956001 ttttccaatc cccatccgca tgagaccttt agcggtttga cggcacagac tgtcaaattg 1956061 agcgtacgta tagcggatat ttcggtctgg atacacaaca gcatctcgat cgggatacgc 1956121 atcagctgtt tgttccagca gcctgccgat tgtggaatgg atgagttcag ccattcattg 1956181 ttcctccttt cttaatgata ggaaagcgtt tacattttta ttttaaaagc tgtctggcga 1956241 tcacgagacg ctgaatttca gatgtgcctt caccgatttc cattaatttt gcgtcccgca 1956301 gcatccgttc caccccatac tctttcatat agcctgaacc tccatggatt tgaatggctt 1956361 gattgcaagc tcttgtcgcc atttcagatg cgaatagctt ggcgtacgcc gcttctttgg 1956421 tgaacgggcg gttatgatct ttcagccagg cggcttttaa caccatttgc cgtgccagat 1956481 caatttccat cgccatgtca gcaagcttaa attgaatcgc ttgaaaggaa gaaatcggct 1956541 gtccaaactg ctttcgctct ttcgcatatg ccaatgatgc gtcaagggcc gcttgggcaa 1956601 tgccgactgc aagagcagcg atggagattc gaccaccatc cagcgtatat agaaactgtt 1956661 taaacccttt tgttggatcg ccaagtaagt tggccgcagg cactcttaca tcttcaagca 1956721 agatttccgc tgtattcgaa ccgcggacgc ccattttatc gtacgggctc gtaatcgtaa 1956781 gtcctggtgt gtcagttggc acgattaatg cggagatgat gttttttccg tctttgtttt 1956841 tgcctgttac ggcggttaca ataactgtgc gtgcgtagct tgcattagtg atccagcact 1956901 tttcgccgtt gattacatac tcgtcaccat ttgaaatcgc ttttgtttga gtgcctcctg 1956961 catctgagcc ggcatttggc tccgtcaggc cgaatgatcc gagtgctgtg cctgaagcca 1957021 gcggcgtcaa atgcgtctgt ttttgctctt ctgttccgaa gtagtaaaga gggcttgcgc 1957081 ctagcgagac cgctgcagca tagcttaatc cagtactgcc gcaggctttg ccgacttctt 1957141 caaccgctaa ggcatatgaa atcgtatcac cgccagatcc gccgtattct tctggaaatg 1957201 gaatacccat cagaccgagt tcacccattt ttttaaatgt ttgcatcggg aactcgcctg 1957261 tttgatctac atgttcagcg tgaggagcaa tttctttttt cgcaaaatct tttaccattt 1957321 cacgcaccat ttgttgttct tttgtcagct caaaattcac atcgtttcct ccttcacatc 1957381 tttgtaacat cctattaggc gagttctata atcattccct gacaagaaaa gtctgaaaat 1957441 taaaactgaa tcatttttta tgtgataata tcagcgggat gagcaaatac atgcagtagg 1957501 cgcataccat ccatatcgta aacgcaataa cttggccctt tgataaagcc gggaagatga 1957561 ggggaagatt ccaaagggaa atcgtatcca tcaataaacc gaccgctgat ccccatatac 1957621 ctagcttgat caccgcgaac tgtgattgat cgagtttttg atagagaaag aacacaaggc 1957681 ataaaacaag agcagtgccc gctcccaaga gaagaaagtt cggcaaaaag gcttcttcag 1957741 ccggatcagt caacacagca tctccgaaca gcacaaaaaa taatgtggca cctaaccaga 1957801 ctagaaatga aaacgtaaaa cacgtcctgt acgtgtttct cttcgatttt atttttattt 1957861 agtactagtt tctcagattc caataatggt aaatgtccaa acaccgcctc catattcatg 1957921 tgaatctcac ctttgttttt taaaaaattc agcggtttac catcgtttcc tgtcccaaaa 1957981 tcacttttta aaaaaagacg acttagaaag ccgtccttct catttcttat tttgttgttc 1958041 gtttggaagc tttgctttcg ttatgaagcc ggtctgctga agtgacataa tacgtatatt 1958101 tcttgttggg atctgccgtg ttatctaaga aggtttgctg ctcatgtgtt tttctttgcg 1958161 ttgccagcaa tgttctctgc tttttccctt cggctctgta tatcgcataa taggctgttt 1958221 ctttcgtttt ttgatttgat gggtgatctt taatctgcag aagattgccg tttttgtctt 1958281 cggtgacttt cgtaagcttc ggtttttttg gggcggtatt gtcaagccaa ggcatttgcg 1958341 gaaccagtgc cggcttgctg taaagatcgg tgctgagact gtctttgatg ccaagcggat 1958401 ttttgttgag gtccttgagg ctgaaatgca tgcttccttt caccagttca agctggcggt 1958461 tcaaagtgat ttgccgcaca tattcctcag gatcggacca aggcggatca aaattgttat 1958521 tgattttata tgctgcctgg ccaatatata agtgaacagg cctatttttg acttcattgc 1958581 tccaccaatc agccagcacg tcgtaagccg ctgcgttaaa gccgatactc caataaattt 1958641 gcggagcaat ataatcgatg tcgccttctt ggatccaatg ccttgtgtct gcatatagat 1958701 cgtcataatt tctgacgcct gcttttgtat tcgatccggt cgggtcatct gcggcgtttc 1958761 tccatactcc aaagggactg atgccgaatt tgacatacgg ttttgcagct ttaattgttt 1958821 ggttgatttg tttgacaagc tggttcacat tgtcccgccg ccagtcatcg atattagaaa 1958881 aagcgtcttt tccgtattgt tcgtactgtg cttgatcagg aaattcctgt cccgctattt 1958941 tataagggta aaaataatca tccatatgaa cagcatcgat atcataatgt tttacgactt 1959001 cttcaatgcc tttgacgata aaatctctcg cttctggaat gcctggatga taatacagct 1959061 ggtttccata ggcggcaacc caatctggat gttttcttgc cgggtgatcc tcagacaatt 1959121 tattaagatc tgtatgattc attgtaatac ggtaaggatt aaaccacgcg tgaaattcca 1959181 aatttcgttt atgggtttct tcaatcataa atgcaagagg atcatagccg gggtccttcc 1959241 cttggacacc ggttaagtat tccgaccaag gcccgtaagc tgacggataa aaggcatcag 1959301 ccgtcggttt aatctgaacg ataacggcat tcattcccat tttttgcaca tcgtccagca 1959361 gtttgatata ctcctgtttt tgctctttca cagataaccc ttttttggac ggccaatcaa 1959421 tatttaatac ggaagcaatc catacggctc tcagctccct gtcagactgc gcattggcca 1959481 taaacggaac ggaaatgaca aacgttccga tgatcaagct gacaaggaaa cggacaatcg 1959541 acttttggca aaccttcatt ctgtttcttc tcccccatta catcactttc actattcgct 1959601 attacggtat tcccgggcta taaaagggtg attaacagaa tgtctatctc actaaataaa 1959661 cgaaaaaagt cctaaagcat gttgtgaacc gcttttagga ctttttatca ttcatcatgg 1959721 tttgcagact ttttaacaca tcaataagtt ttacgccgac accgacagcc gtttcaagga 1959781 tcgcttgtgc tccggcaatg gctaaaataa agatcagcgg tattgcaata cgaggcaaaa 1959841 aaagatagcc aagtccgatc aagatggcac accaaacacc ggcacaccag tagcaattga 1959901 gcatgtatcc aaagttagaa gccggcacgc ttttttcatc tacatgcccg ttttgatcaa 1959961 caatcctttt ctttttcata aaaggttttc ggataaattc tgtgattttg tcaaatacaa 1960021 tcaaatgtgt cagcctgtaa ctggctagaa tcagcatgat aaaagttaga aaagaaagac 1960081 ggtccattga gaagcctcca agaaaaagga tgatgttatc attcccaagt gtcccttatc 1960141 cattcttgat acaaaaagaa agacggacag agaatggcct ctgtccgcta atccgcttta 1960201 tcgtttgtgc agtattactt gatttgaagt gatcttttct aaaatgtcga ggatgatgtc 1960261 ggcattcttt tcagcatatg ttccttccag catgtcttta tgagcgccaa aacccgtgta 1960321 ctcactatag tttccgcagg cgccttccca tttcgttaag cctgtatgcc cgctggtttc 1960381 ggggtggatt ccagcttcga tgaaatgaat gcttgctttg atgtggcctt cattcagcaa 1960441 ttgtgcccaa tattcctgat agtttctttt tttcttcatc accttttctc tgactgcttc 1960501 aggcagatat gctgcagatt cgtcattacc ggtatcgata ggcaaaggct gttcttttag 1960561 ataagcgtcc acgataatga agtcgctgac ttctaatcct ttgcgctcca tagcctgtgc 1960621 cacttcaaaa gccaggtttc cgcctgcaga gtagcctaat aaaacgtatg ggccctcagg 1960681 ctgtatgtcc gtcatgcaat taacatattg ttcaatgcgg gtgtcttgtt caataaagtg 1960741 aaacccgtat acggctgcct tctcattcag caataaagca aggtctttaa aataaatgcc 1960801 aaatcccgat atcggcggga agcagaaaag attttgcgcg ccgtgctggt tcagtttgat 1960861 cacatgctgt tcatttgctg ctgtcagctg tttagaataa agtttttcgg caagctgagc 1960921 gattgtcgga tgttcgaaca agaaatcaat cggtatgtca atgttctgct gatgttttag 1960981 tgtatgtatg acttgcagtg ctcttagtga atgtccgcca atagcaaaga agtcatcatc 1961041 aatactgatt gtgttaacac cgaggacttg cttccaaatg ttcgccaatt cttcttcaac 1961101 caagtttctt ggcaatatga tgttctgtcg tttggcaggc ttattttctg gaataggcag 1961161 cgcgctgcgg tctatttttc cgtttccggt aagcggcatc cgctccacac gcacccagtg 1961221 ctgcgggatc atatagtctg gaagcacacg cgccaaatcg gcgcgaaaat ccgtatctgt 1961281 ttttttgtga tcaccgacgt aatgagtgta cagctgcgcc tctccatctt tttctctcaa 1961341 tgtcactgct gcttcttgaa cgccttccat ttctaacagg cgcgcttcta tttcggcagg 1961401 ctcaattcgt tttccgcgga ttttcatttg cctgtcaatt ctgctgatgt attctaagtt 1961461 tccatcaggc agccagcgcg ccaaatcacc agtacggtat attctttctc caggcaagaa 1961521 aggatgagga gaaaacacag catttgtcag atctactctg ttcaaatagc ctttagcgac 1961581 tccatcaccg ccaacacaaa gctcgccggg aacgcctatt ggcaaaagac gtccttttgt 1961641 atctaagatg taagcggtgc tattactgat tggttttcca atcggaatcg gccccgcata 1961701 gtctctcttc atttcaaaaa aggttgaaaa agtcgtgttt tccgttggcc cgtaaatatt 1961761 atgaagcgcg agatctggac aggcgtgtct gacggcattc atcagggcag gagagagtgc 1961821 ttctcctccg acatataacg tatggagtcc gcgaaacatg tcagctcgta cctgtgccag 1961881 ctgattaaaa agagctgtcg ttaaaaatag cactgtaatg tcattttcaa gcaaatacgc 1961941 tccaaaccga tcaggtgtca gcattgtcga tttatcaatg atatgaaggc ttgcgccatt 1962001 taaaagtgcc ccgaacattt caaaggtgac ggcgtcaaag ctgatagatc cagtcataat 1962061 aaaccggtca tcaccggacg cagacgtgta attgctgttt ctgacaaggg acacgacatt 1962121 gcgattcgtg atcatgaccc ctttcggccg gcctgttgat cctgaggtat acatgatgta 1962181 cgcaagatca tccgggctgg agctgatatt aatagggata tcgttctctt ccatcaatcc 1962241 ctgcgcatct gaaatgatac atgttcctga gaacgcagcg ttttgctcca atcccttttg 1962301 aacaatcagc atttttgcct gcgtttcctc aagcataaag ctgactcgtt caggcggaag 1962361 ctccgcatca agcgggaggt atgctccccc tgcttttaat acggcaagca cactgatcat 1962421 gaattcggga gaatgtgcag ccaatattcc ggctgtctcg tttttccgaa atcccttttg 1962481 aattaactct ctggcgagcg cattagagcg tttatcaagc tctttatacg aaatagacat 1962541 attgccatac acaagtgcgg tatggtctgg cgtcttttct gcttgttcgc gaaataaatc 1962601 gataattgta tgattctttg gatactccgt ttttgtattg ttgaactgtg tgacaatctg 1962661 ctctttttct gttgcatcaa gaaaagaaaa atcagcaatt ggcatatgag ggtgctgtgc 1962721 agctgtgcta agcgcttgcg taaattgcct cttgatacag ctgatccagg cagcatcgta 1962781 aacgaatgca ttatagctga acttgatgac aagctcttcg ccaggagcaa cgacaagatt 1962841 aaagttatat cctgattgct cggatacttg aacttgatcg atttgcagcg gtgaatcggt 1962901 ttgatcagcg gaatcggcga ttttctgctg taacggatag ttttcaaaga cgataatgtg 1962961 atcaatcagt tcctgtttta atgcggtgtt tgcctgaata tcaaataaag gctggcaggt 1963021 aaacggctca gcttccagca tttctttctg gcagcgtatg agcagctcgt gaaacgtttc 1963081 gtcttggtgt gttttaattc gaatcggtat ggtattgata aacaacccta tcatttgctc 1963141 cacgcctggg atttctgacg gtcttcctga tacaactgcg ccaaacacaa cgtcgtctgt 1963201 gcggttatat tgctgcagca tcacacccca gactgcctga ataagggtag cgagcgtgac 1963261 gccgtgttgt ttggcagtct ctttcagctt gtctgtcagt ggtttattta atgaaaatat 1963321 caaatcttca cggtgataac tttcttttgt ttctttatca gacacacgag gcagaggtga 1963381 tggagcgctg tagtttttta aataggtatc ccagtaggcc gctgcttttt ctttgtctcg 1963441 gtttgtcagc catgaaatat aggtgctgta cggacggaca gggtctaatg aaagcggttt 1963501 tcctgcatga atcgattgat aaatttgcat aaattcctgc ataacgatac ctaggcacca 1963561 tccgtccatt aaaatgtgat ggtgactcca gatacagaca tgctcatctt tagctgtttt 1963621 gaatagagaa atccgcatca gcatgtcttt ttgcagatca aagccttttt gcttgtcctt 1963681 ctctttaaag cgttcaatat actcattctg gtcgtttgtc ggcagatgag aaatgtcttc 1963741 gctgttcaaa tggaattcac gttctgtcat cacgacttgc cgaggtcccg acaaatgcgg 1963801 gacgtgcggc aaaaacacgg ttctgaaaat atcatggcgg tcgataatgg cttgaatgct 1963861 gcgctggaac cagtcatagc tgaggcttcc tttaatggtg aagagcgact gctcaacata 1963921 cgccccctcc tctttacgga ggaaggaatg aaacagcatc ccttcctgca tatgactcag 1963981 aggataaatg ttcttgattt ttttaatggt attcatagtg tctgcacctt tcttcacgga 1964041 ttcattagtg aaaactgagc atatcagcga tctcttgcag ggcgtcctcg gtcagttctt 1964101 gatcatcaaa atcactgatc gtcttttctg tttcgctttt gttctggcag tgttcgatca 1964161 gctgtaataa aaattgacgg catgtttcgc taagctgttc gatggttttg cgctgaaagc 1964221 gggcattgtc ataagtcata ttgacagtca attttccttc tgcagcgatt gcgctgatat 1964281 ccagcgactg ttcacggttc catgttgtgc tgatatcacc tccggcaccc agcggagaga 1964341 atgagaaggc gtcctcctca ggtacttcag ctgtgcggcc gctttcaaat tgaccaagat 1964401 aattaaagct gatttctggt gcacctgtga aattgatgtc ttttttgcca ggcggagtca 1964461 aatatttgat gacaccgtag ccgaatcctt tgtcaggtac acgtctcagt gtatcttttg 1964521 ttgtttttag cacatgaacc atgctttctt ccgaatctgg caagtctgcg ttcagtttaa 1964581 tcaataacgg ataaatggcg gtaaaccatc caatcgtccg gctcacatct attcctttta 1964641 atacatcctc tcgcccgtgg ccctctaatg atagtttgaa ggcggattga ttggtccaat 1964701 ggcgcagcgc aagaatgaca gaagcgagca gcatgtcctg cgtatcagtg ttatatgcgc 1964761 tgttggcgtc ttttaagagt gctgctgtct ctttatcgtt taaggtaaac gaaattgtgg 1964821 accgttgtcc ctcgtgtgct ctagttccat cgatttgatc aaaaggcaat gcctctgttt 1964881 gatactcttc ggcttcgcgc caatacttga gctgtttcat tagctgctgg ctttcagcgt 1964941 agtcagagag ctttttcgca tacgctttaa acgagcttgt tttaggcggc agtttgatat 1965001 cctccccgcc agcagcttgg cgatacccta aagccaaatc ttcaagcaga acccgccatg 1965061 agatgccgtc aacgacgagg tgatgagcag ataaaaataa gaaatcaccg tcaattgtgt 1965121 ggaaaagacc ggcttgcagc agcggaccat tcttcaaatc cattttctgc tgaatatcaa 1965181 gtacatggcg cttgataaga ggttcatacg gtctatttcc atcagtgccg tccggagctg 1965241 acaaatcaat catctgaagg ccgtacaacg cgtcgtccga atgactgagc ggccgattat 1965301 attgatccca ctttccttgt tcattctgtg taaacaccat tcgcagcgca tcatgatgac 1965361 acgttattgc ttttaacgtt tttcgcagtg cgtcttcttg tacagaggtg cttcgatgca 1965421 gcattacgga ctgattaaaa tggtgttttt cttttatatc ttgagaaaga aaccattttt 1965481 gaacaggcga ccattgtacg tctccctcaa ccgcagcttg gctggaactt gtatctgaat 1965541 cacggatata agctgccaat tcttgaatgg tcggatggct aaacaaatct ttcactgcca 1965601 tttgcttgcc tatccggtga agccgcgcag atacctgtaa cgctttgatt gaatctccgc 1965661 caagttcaaa gaacgaatca gctgttccga tcttttctgc ccccagtact tctttccata 1965721 tatctgccag tatttgttcc attttgctgg atggcgggag gaatggacgt tcaccttcgt 1965781 ggttgtatac aggttttgga agtgctccgc gatccagctt gccgtttggt gacaatggaa 1965841 gtgagtccag tttttcaata aacgcagggt gcataaacac cggcagcttg ttttgtaatt 1965901 ctgagcgtac agcatttgtg ctcaaccctg gttttgtcac cacataagcg cttaattcgg 1965961 tttgtcctga cgctgttaca tgagcaacta ctgcggcgtc ttttacaccc tttatacacc 1966021 ggatgaccga ttcaatttct ttcgtttcta cacggtatcc tctgattttg acttgatcat 1966081 cgattcttcc gagatattcg agtgtaccgt cggccatcca tctggcggcg tctcctgttc 1966141 ggtacattcg tgcttcgggt ttaaatggat tctgcgtgaa tgctctctct gtcagttctg 1966201 gaagattaac gtaccctctt gcaagccctg ttcctgctat acaaagctct cccgcaacac 1966261 cgattggctg aagctgatga ttgctattta aaatcagcac ttgagttccg tcaatcggct 1966321 ggccgatgct tacgtatgcc tgcttttcca tatgtctcat gacggtagtc gccacgctgt 1966381 tttctgtcgg tccatattcg ttggcgagtt cggtatgcgg acatatagct aagctgcggg 1966441 cgatcaattc gcggtcagcc gcttctcccg ccagtgtgac gactctaagc gtctttacat 1966501 cttccggctg cactacgtcc aaaagcgctc gatataaaac aggcacaata atcatatgtg 1966561 taatccgttg acgagacagc tgatgcttaa tggccagaat atccttcgct tcctcttcat 1966621 gaagcaaaac ggcttttgca cctgacaaaa gcggtgtaaa catactagtt ataaagccgt 1966681 caaatgagaa agaaaagagc tgcagaatgg tatctgtctc gttgaatgca taagcgtttc 1966741 gccgccactg aagagtgtta gcaatccctt tatgctcgac cattacccct tttggacggc 1966801 ccgtcgttcc tgaagtataa atgatataag ccaaatgatg ggcagacgac atttgcggca 1966861 gcggcgattt gtcgtcttcc tctacgcttt ctatcgtcaa gatctctcct tcaaagtcag 1966921 caagtactcc cagatccgct tcatttattg tcatcagcag tttcgttccg ctgtcgctga 1966981 ggatatagcg tttccgttct ttcgggtatt caggatcaat gggaacgtaa cagcctccgg 1967041 ctttccacac accaagtatg gatgctatca tactgaacga acgatgcatc atgatgccta 1967101 ctggtgtgtc cggcttaaca cctcggctgc gcaatgcacg tgcgattcca ttggaccact 1967161 cgtcaagctc ctgataagtg agtgttttgt ctccgctgac aagtgcagaa gcttttggtg 1967221 ttcgtgcagc ttgctgctca aacaattgac tgattgtttg aactccgtat tgattcgctt 1967281 gcccggtgtt aaactcatta agcagctggt gccgctcttc ttgggtcagg atgtcgatat 1967341 ggttgagtgt caccttcggg tttttgccga tgatgctaag tacatttgtt aaatgcgatg 1967401 cccagcgttc aatggtggtt ttctcgaaca atgcggttga atattcaaaa aggaaatgaa 1967461 tgtttccgtc gccctcagat gcctgtagtg tcaaatcgaa tttagaaacg agatgagaaa 1967521 cttgtgccgg cttcatttgc aaatcatgaa gatgcaatgg ctcgtaatca ttattttgaa 1967581 caactaacat cgcatcaaac actgggttcc ggctcatatc tcgtgtcaat tcaagcttat 1967641 cgacaagctc ttcgaacggg taattctggt gctcaaaggc ttccaatgct gtctcacgca 1967701 cttcctgcaa atactgtacg aatggcttcc cgccctccgg gcgcgtccga agcgccagcg 1967761 tgttcacaaa catgccgagt atcggctcaa gatccttgtg cggccggccg gcgattggcg 1967821 agccgacgat gatatcttcc tgtccgctta agcgtgacaa gaacgcggtg taagccgcaa 1967881 ggagcaccat gtacagtgtg cttccgtttt ctcgtgccag cttgtgaagg cctgatgcaa 1967941 cctctggttc cagcgtaaat gagaccttgt cacccgcgaa gcttcgcacc ggcgggcggg 1968001 catgatcagc ggggagatcc agcacaggca gctcgccctc gagctgcttc agccagtacg 1968061 cctcctgcat tttgtacgcg tctcctgttt tgaatccttc ttgccatacg gcataatctt 1968121 tatattgaat gcgcagcgcc ggaagcttcc gattattgta cagctcgccg aattcttgaa 1968181 tcagaatgtt gacggaaaca ccgtctgaaa tgatgtgatg catatcaacc agcaataggt 1968241 gccgctcatc tgataccttt acgatttggg cacggaacag cggcgcttgg ctgagatcaa 1968301 acggtttgat aaatgcggct gcggcctcct gttcggttcg tgcgccgaga actgtagtct 1968361 gtaacgtaaa cggcacctcg tcatggatgc gctgcaccgg atcgcctcct tcgtcctgtt 1968421 cgaaggaggt tcgaagcgac tcgtggcgct tgatcagctc ttggaaagct ctgtccatcc 1968481 tttcagggtt gagcttccct tcgagctcta acacagccgg catattgtag cctgtccctc 1968541 cgtcctccag ctgctgaagg acataaatcc gcttttgggc agaggaaacc ggataggttt 1968601 cctgtttttc agcgggctta atcgcttcat atggactgtc cgttccttca cggataacgg 1968661 tagccagtcc ttctaccgtc ggatgggcaa acacatcttt tagcggcacc tgtacatcga 1968721 attctttggt gatccgtgag acaagcgccg ttgcttttaa ggaatgtccc ccgcggtcaa 1968781 aaaagttgtc gtgaatcccg acagggccat ttttcagcac gtcctcccac agctgagaaa 1968841 gcttcatctc agtcacgttt ctcggcgctg tgtaggtctc cgcatctgcc gctccgccag 1968901 gagctggcag ggcgtttcgg tcgagctttc cgcttggcgt aaccggccac tgttccatct 1968961 ctatcatata ggctgggacc atgtagcccg gcaacagtct ctcaagctgc gctcggactt 1969021 cgtttctttg gagcccttct acataagcgc ataattccgg ctccccgctg tctgtccgta 1969081 cggtaacggc cgcctctctt acaccttcta tacttcttag tgccgcttca atttctcccg 1969141 gctcaatccg gtagccgcgg attttcacct gatcatccgt gcgcccgagg aattcaacat 1969201 tcccgtcagg gagccagcgc gccacatccc cggttttgta catgcgttca cccgggtaaa 1969261 acgggtcttc aagaaaacgc tcctccgtta atgccggccg attcaaataa cctctggcaa 1969321 cacccgctcc ggctatgtac agttcgccga tacatccaac aggcagcatc cgctgattct 1969381 gattcaggag atataatctg acatgatgaa caggttttcc aattgggatc cgttcaagtt 1969441 tttcatgcgg cggacaatca aagaatgcag cttctacggt tgcttccgtt ggcccatagg 1969501 aattggttat tgaaacattt ggaagcaact cgtaaaatcg ggagacaaga tgggtcccca 1969561 gctgttctcc cccagaaaac actcgcttga gtctgtttgt cttaatcggt acagagcgat 1969621 attttatatg ttctaaaaat gcatggagca ttgaaggcac aaaatgcata gctgtgatct 1969681 tttgttcttc tatggccttc gcgatcactt caggttcttt ttcgcctccc tgaggaagca 1969741 gataaacaga agctccggca taaggccacc aaaacagctc ccatattgaa gcatcgaatg 1969801 aatatgatgt tttgtgcata atcatatctg aatgctttag ctgatagcgg gactgtaggg 1969861 aattcaaaaa attcaccgct gatcgatgtt caatttcaac acccttaggc atcccggtag 1969921 agccggatgt atagatgaca taggctaaag attgcgggag aacatccaca ttcggattgg 1969981 acaaacgatg tgccagtccg ctatttgtct gattgagata gacaatctct cctgtaaatt 1970041 ccggaacatg aaggccggca gactgaagca ggagaatgtt tgtaccgctg tcctccagca 1970101 gaaagctgat tcgttcttcc ggataatccg ggtcgatggg cagataagcg ccgccagctt 1970161 taagaatgcc ataaatgcca agcagcattt caggtgaacg ctttcctata atggcaacag 1970221 tcgtttcggg ttttaccccc cgtccgatca gctcccaggc gatacggtta gcctgttcgt 1970281 tcaattcttt ataggtcatc actccatctt cgaagataac ggccgcctga tcaggcgttt 1970341 tttctgcctg ctgttcgagt gcatagtgga gcgtttgatt cattgaatag cccgtctcct 1970401 caaacagatg gcatgattca atgaaatctc gctcttcttc ttttgttaag attggaatat 1970461 tgtccaattc tgtttcagga ctggcagctg tatgttccac aagcgtggtg aaaaggctgg 1970521 cccacctttg gatggtttct ttctcaaaca aagctgtact gtattcaaac tgacagaaaa 1970581 gctcggaatc atgctctgta acgtataggg aaatatcaaa ttttgatatt gggtgctcca 1970641 agtcgttcca ctgaagctgt acatcattca tttttagctt ttgctgttcc atattctgaa 1970701 ggactagcgt tgtgtcaaac aaaggattcc ggctcatttc ccgctgcaca ccgagtttgt 1970761 ccacaagctc ttcaaacggg taatcctgat gctcatacgc ttctagtgcc gtctgtctga 1970821 cttctttcag aaattcctca aatgtcttat tacccgccgg gcgtgtgcgg agagccaatg 1970881 tattgacgaa catcccaaga acagcttcaa ggtcggcatg gggccgtccg gcgataggtg 1970941 aaccaatcac gatatcatcc tgaccgctta accgagacaa aaaggctgaa tacaaagcga 1971001 gaagcgtcat ataaagcgtg cttctgtttt tatgggcgag ccgctttatg cgggccgtga 1971061 tctctttgtc caattgaaag gttacttttc cgcctatgaa ttgccgttct gccggacgtc 1971121 gtttatctgt tggaagctcc agtataggaa ggtccccgct aaactgctgc tgccagtaag 1971181 tctcctgctt ttggtacgag tctccctttt taaatttctg ctgccatacg gcgtaatctt 1971241 tatattggat ccgcaatggc ttaagctgcc ggtttgcata aagatcggta aattctcgga 1971301 ttaggagctg aacggatacg ccatctgaaa tgatatggtg catatccacc agcaatacat 1971361 gcttctcgtt tgacacttct ataaggcctg ctctaaataa tggcgcctgg ctgagatcaa 1971421 agggacggac aaatccctcg atagtggtct ctttacttaa cgtaaacggc acttcggtgt 1971481 ggatacgctg aaccggctcg tcatcagctc cggatacaaa ggaagttcga agcggctcat 1971541 gccggctgat cagttcttta catacagcag acagtttggc gacatccagt gcaccttcca 1971601 gttctaagac cgcaggcatg ttataggcga caccctcatc aagctgttga agcacataga 1971661 ttcgtttttg ggccgaagat acaggatatg tatccctttt ttctgctggt tcaattgctg 1971721 catacagatt ttgttctgcc tctcgaataa ttaaagctaa tccttcaaca gtcggatgag 1971781 caaagatgtc cttaagtgaa acttgcacat ggaattcctt tgcgatccgt gacataagca 1971841 ctgttgcttt taacgagtga ccgccattgt caaaaaagtt gtcttggatg cctatatgcc 1971901 cattctttag cacatcttca aatagttgcg aaagctttgc ctctaacaga tttcgagggg 1971961 cagtatatgg gtttccgctg attgaagcat ctggctccgg aagtgctgcg cgatctactt 1972021 ttccgtttgg ggtaagaggt atgctgtcaa cccatatcca tttcgccgga atcatgtatt 1972081 ctgggagctc actagccata taactgcgta aatctattgt gttcagcttt tgtacactgc 1972141 aatagtaagc gcataattca tgttcaccgt tttgatcttg ccagatgaga atggcagcct 1972201 cactaatgtc cggatgattc attagcgtga cttcgatttc ttgcggctca attcgataac 1972261 ctctgatttt cacttgattg tctgcccgtc cgatatattc gatgttgccg tcttcaagcc 1972321 gtctggccaa atcacctgtc cggtacatga tcacatcagg cttgaatgga tcggatgaaa 1972381 atttgtcgct tgtcagttta tcgtgattga catatcctct ggcaacactt gcgccggaaa 1972441 tatagagttc gcctggtacg ccgcatggct gaagctgttt ttgatgattc aaaatatata 1972501 gatcagtaca gcctatcggt ttaccgattg gcggaagctc aggaataggg tctccaggat 1972561 gaatggtata cgtagatacc acatgagttt ctgaaggtcc gtaatgattg tgcaggtgta 1972621 tgccgcgttt acgcaacaca tcttggaaaa ggtctgaaat cattaattgt tccccggctg 1972681 cgatcaggtg tttgacgcca tcaggaaacg agttcgcaag ttctcgctcg ctgaaaatca 1972741 ttttgataaa agcagttggg agaaacacaa tattcgtctg atgcttgttt ataaatgcaa 1972801 acagctgagg cacatctctt tttatggctt ctggcacgat gtggagtgtg ccgcctttca 1972861 gaagcgcaga aaatatttct tgatagcaga cgtcgaagga aggcgtcgca aattgcagaa 1972921 catctgcttc aaagtcaatg ccggagtgag tatattcgaa cttcagcaag ttagccatgt 1972981 ttcgatgctc aaattgaaca ccctttggtt tacctgttgt gcctgatgta taaatcatat 1973041 acagcagatc gtcagcattg ttgactgact ttatgttact gccgtctact ttgctttcga 1973101 tatcttctgg atgagtgata atgtaattgt cttctaacga tgagggaaga tgcgcttgtg 1973161 aaacaacatg cgaacagccg caatcatgca gaatataacg gattctgtca gcagggtaat 1973221 gcggatcaac cggaacaatg gcgccgcctg ctttcaagat accaagaaca cctgtgataa 1973281 acgccgctga gcgttccatc ataatcgcaa cgggttcctg tctcacaacg cctttcattc 1973341 gtaaatgccg tgccaatctg ttagccgctt tattcagttc tctgtatgtt aatgagcagg 1973401 cttgatcaat tacagcatga gcatctggtg tcttttccgc ttgcttttca aacatggcat 1973461 ggatggtttc gtaaactggt gtttgatctg tgatttctcc aatcagctgc cgcttttcag 1973521 tatctgtcgt gatatcgatt tcttcaggtg gaagattcgg attatttaag atttgtgata 1973581 cagcattcag aagatgctct ttgacagaga gcacaaaaga ccgatcgtgc tgctccgcat 1973641 catagttcat tttgatatga atttcttccc ctggcgccac cataagataa aagctgtagt 1973701 tggtttcatc tgcgacagtg aaattatgaa tctgaaaaag atcagaagca tgttcctgtt 1973761 tgttcagcat ttgaatctct tgctgcaccg gatagttttc aaatacgaga atatgatcaa 1973821 tcagcccttg cttaacagct gagcgggatt gaatctcata taaagggtgg tagctgtacg 1973881 cttcagcggc aagacggtct ttttgcatat cttttataag ttgaagaaaa ggcgtttttg 1973941 ccccctgcac ccgaaccggc atcgtattaa tgaaaagacc taccatatgt tcaatgcctt 1974001 cgatttctgc gggtcttcct gaaatgacag aaccgaatac ggcgtcatcg ttattattat 1974061 atttttgcag cagaatgccc caaatggtat gaaaaatcgt actgagtgtc acttcttctc 1974121 tagcagcaag ctctgaaagc ctgctgcttt cttccttaga gaatgaaaat gtaacgtgtt 1974181 cctgcctgct ttttcccttt gtttttttct gcttcgggag cacggtttgc tgttcgtggc 1974241 cggaaagata atgatcccaa taagaaaccg cctgctcttt gtcttgctcc atcagccatt 1974301 tgatatactt tccgtatggc tggaccggct ccaatgttat tggggatgca tttacataag 1974361 atgcgtaaat atgcagaaac tcctttagca caatgctgag gcaccaaccg tccatcatga 1974421 tatgatgaaa ggtccaaatg caagagtact ggctctctcc tgtttgaatc agagcgatgc 1974481 gcatgagcac atccttttgc aaatgaaacc cccggtcccg gtccttttct ttccattgct 1974541 cgataaactg tgattgctcc gcctcgttta aatgagtaat gtcttcttcc agtacgatga 1974601 catttcgttc tctcagaaca acctgctggg gggaggaaac attttggctg ataaaaatcg 1974661 ttctgaaaat atcatgtctt tctacaagag cgttgatgct gttttgaaaa aactgcgggt 1974721 tgacttttcc ttctattgta aaagaagctt gctcaacata cgcctgtgaa tctttttgca 1974781 ggagggaatg gaaaagcatc ccttcctgca tgtaagacag cggataaata tcctgaattg 1974841 aattcgcttt tgtcatgttc atgtctcctg tcacgatttt ctacaattct tccaccaagc 1974901 tggatatgct gtccaagtcc tctgccgtta atgattgact gctgaaatcg ctcagtgtct 1974961 tttctgcttt ctgttgaccg gcgcagtgtt tcataatgtc cagcaaaaag tgttcaatcc 1975021 tgttaataag ctgttccatt gtgtttctgt gaaagcgggc tggcggataa ctaagattga 1975081 aatggagctt tttgtctgct gccattgcac tcatctcgat gatttgctcg cgcttccatg 1975141 tatgagtgat atcctttccg ctaccaaggc ttgatgggcg gaaggtgtcc tgtctttcga 1975201 tgtcgttgaa ctggcccaaa tagttaaagc tgatttcagg tgtttttgaa aacgtaatgc 1975261 ttttattttc agggtgtgta aggtatttca gcataccgta acctacccct ttgtttggta 1975321 tccggcccag tgtatcttta acggttttta ctgaggttcc gagctcatcc ctatgatttt 1975381 caaagcttat gagggccggg tacatggatg taaaccagcc gaccgtcctg cttatatcta 1975441 actctggcag aatgtgttct ctcccgtgtc cttccatagc gatacggagc ttgcttcctc 1975501 ctgtccattc acaaatcgcc aaggatgctg cggttaacag aatatcttgt gtatctgtgc 1975561 cataggcgtg attgacgttt tgcagcaaga cggcggtgtc tgcttcagtc agtgaaaagc 1975621 ttaatgagtc ccttttgctg aagtcgatgt tcacatgatg cggtatttca tagggcagtt 1975681 ctgcggcttg ctgttcttct acacttcgcc aatacgcctc ttcgcgaatc agcttactgc 1975741 tttgggcata ttcctgtatg cgtcttgcgt attcctggta ggaatccgtt ttaggcggaa 1975801 gctggatcgt ctggcctgca gcagcttgtt gatatccggc tgacaaatcc tccagcaaaa 1975861 tccgccatga gacaccatca acgacaaggt gatggatcgc aaggaacaag taatctccgg 1975921 tcagtgtttt aaacaaagcg gcgtgcaaca atggtccttc ctgcaaattg atgctttgct 1975981 gaagatcggc aacttcttgt ttgattttcg tctcccagcc gctttctgac tgtgaaagat 1976041 cagagattct taagctgtat agctgtgact catgaatgcc ttggttgatt tgaatccatc 1976101 gcctgtcatc gttgcgataa accatccgaa gcgcatcatg atgctccgcc agttttttca 1976161 aggctggtct aagggcgttt tcagacaaac gtccagaatg gaatagcatg acagactgat 1976221 tgaaatggtg tctttcttca atatcttgtg aaaaaaacca ttgctgaaca ggcgtccaag 1976281 gaacgtcacc ctgaatgggt ccttgctcta tgattctctc tgacttacgg ataaatggtg 1976341 ataagtcctt tatctttgga tgacggaata aatcacttac ctgcaagctt agtccatagc 1976401 gcccaaggcg tgcagaaact tgaagggctt tgattgaatc tccgcccaat tcaaaaaacg 1976461 aatcctctat tccgatcctc tggatgccta gaacctcctg ccagatcaat gccagctgct 1976521 cttcaagttc gttgcgtggc gggatgtatg tttgtttaga tgcgacatct ggttcaggca 1976581 gtgctttccg gttcaatttg ccgtttgatg tgagcggaag agtctccatt tcaatgatat 1976641 acgccgggat catatagttt ggcagcgaac gcgcgagaag agaacgcact tgttcagcat 1976701 tcgtgcctgc ttttacgctg atatagccaa acagctcttt gctcccggtc tgggctgtac 1976761 gtgctaacac tgcggcttct ttgaccccgt ctatttgacg aagtgctgtt tcgatttcac 1976821 ccagctccac ccgatagcct ctgactttta cttgatcatc aatacggcca acgtactcaa 1976881 ttgtgccatc ggaaagccag cgcgccagat cacctgtgcg atacagtcga tcgccaggtg 1976941 caaatggatg tgggacaaat ttctctttcg ttaaatcagg acggcccaaa tatcctctgg 1977001 cgacgccatc tccgccgaca caaagttcac cgacagctcc gaccggctgc agcactcccc 1977061 attgatttaa gataaaagcg gtggaattac caaccggccg cccgatcgga atggaaagtt 1977121 catatgtttt ttgaatgtga aggcatgtcg aaaaagttgt attttcggta gggccatatc 1977181 cattccatat agatacttca gggcagacat ttctgattcg attgacgtgg ctcggcgaca 1977241 aagcttctcc gccaataatc aaatgtttca gctgtgaaaa tgtttgttca ttttgctctg 1977301 tcaaatgatt gaatagagaa gatgtcagcc aaatcgttgt gattccttga tgttctatgt 1977361 acctcttaag ctgatgggaa tcgagaaatg tttgttgatc ggacagatgc aaagcggcac 1977421 catttagcag cggtccgaaa atttcaaatg acccaacgtc gaaaccgatt gatgatgtca 1977481 tcagaaggcg gtcttcaggt gtaaatgtaa tataattgct gtttttaaca agacgaatta 1977541 cacttcgctg ctcaatcatg acaccctttg gtttaccggt tgatccagag gtataaatga 1977601 tatatgcaag tgaatggggc cctgctgaag attcaacgtt cttcgcctct ccttgctttt 1977661 gaatatcttc gattatgatt tgttcacatt caatgcctaa tagccgtttt tctgtttttt 1977721 cagattgaag gagtaatgct gccctgctgt cagacagcat ataagctatg cgttcaacag 1977781 gcagattaga atcgataggc agataggctc ccccggcttt tagaatgccc agcattcctg 1977841 caatgagttc tggtgttctg cctgtcaaca aggctacaac actatcaggc cctacgccct 1977901 ttatctgtag aactgaggca atttgatttg cccagctgtt caggtcctcg taagtgaata 1977961 cttgggtgtc gctgacaatt gctacagcat taggtgtttg ttctgcctgc atttcaaaga 1978021 gtctgctgat ggtttcattt cttggataat ctatttttgt acgattgagc tcgtggataa 1978081 ggtaatgggc ctcatcctca ttcaggatat ttattgttcc gagagcggct ttgttgtctt 1978141 tgatgatgga gagtaacata ttgttgaagt attgaagcca cttttctatc gtttttttct 1978201 tatataagtc agtactaaac tccatttgga acgtcagcaa accgcggggc tgttcctggg 1978261 catatagggt taaatcaaat ttggacgttt gatgcccatt gtttgctgca ggtttgagac 1978321 aaagttcatc cagctccaac gattcctgat ccatattttg aagaacaaac attacgtcaa 1978381 acagcggatt tctgctcata tctcgtgtca attcaagctt atcaacaagc tcttcgaacg 1978441 ggtaatcttg gtgctcaaag gcttccattg ctgtctcgcg cacttcctgc aagtactgta 1978501 caaacggctt cccgccctcc gggcgcgtcc gaagcgccag cgtgttcaca aacatgccga 1978561 gtatcggctc aagatccttg tgcggccggc cggcaattgg cgagccgacg atgatatctt 1978621 cctgtccgct taagcgtgac aagaacgcgg tgtaagctgc aaggagcacc atgtacagtg 1978681 tgcttccgtt ttctcgtgcc agcttgtaaa ggcctgatgt aacctcttga tccagcgtaa 1978741 atgagacctt gtcacccgcg aagcttcgca tcggcgggcg ggcatgatca gccggaagat 1978801 ccagcacagg cagctcgccc tcgagctgct tcagccagta cgccccctgc gttttgtacg 1978861 cgtctcctgt tttgaatcct tcttgccata cggcataatc tttatattga atgcgcagtg 1978921 ccggaagctt ccgattattg tacagttcgc cgaattcccg aatcagaatg ttgacggaaa 1978981 caccgtctga aatgatgtga tgcatatcaa ccagcaacag gtgccgctca tctgatacct 1979041 ttacgatttg ggcacggaac agcggcgctt ggctgagatc aaacggtttg ataaatgcgg 1979101 ctgcggcctc ctcttcggtt cgtgcgccga gaactgtagt ctgtaacgta aacggcacct 1979161 cgtcatggat gcgctgcacc gggtcgcctc ctgcgtcctg ttcgaaggcg gtccgaagcg 1979221 actcgtggcg cttgatcagc tctttgaaag ctctgtccat cctttcaagg ttgagcttcc 1979281 cttcgagctc taacacagcc ggcatattgt agcctgtccc tccgtcctcc agctgctgaa 1979341 ggacataaat ccgcttttgg gcagaggaaa ccggataggt ttcctgtttt tcagcgggct 1979401 taatcgcttc atatggactg tccgttcctt cacggataac ggtagccagt ccttctaccg 1979461 tcggatgggc aaacacatct tttagcggca cctgtacatc gaattctttg gcgatccgtg 1979521 agacaagcgc cgttgctttt aaggaatgtc ccccgcggtc aaaaaagttg tcgtgaatcc 1979581 cgacagggcc atttttcagc acgtcctccc acagctgaga aagcttcatc tcagtcacgt 1979641 ttctcggcgc cgtgtaggtc tccgcatctg ccgctccgcc aggagctggc agggcgtttc 1979701 ggtcgagctt tccgcttggt gtaaccggcc actgttccat ttctatcata taggctggga 1979761 ccatgtagcc cggcaacagt ctctgaagct gtgcacgcac ttcgtttctt tggagccctt 1979821 ctacataagc gcataattcc ggctcgccgc tgtctgtccg tacggtaacg gccgcctccc 1979881 ttacgccttc tatgcttctt agtgccgctt caatctctcc cggctcaatc cggtagccgc 1979941 ggattttcac ctgatcatcc gtgcgcccga ggaattcaac attcccgtca gggagccagc 1980001 gcgccacatc cccggttttg tacatgcgtt cccccaggta aaacgggtct tcaagaaaac 1980061 gctcctccgt taatgccggc cgattcaaat aacctctggc aacacccgct ccggcaatgt 1980121 atagttcgcc ggcgacaccg gaaggctgta cggctaaatg cggatctaaa acatacaaac 1980181 gcgcaccagg tacgggcttc ccaatcggaa tccgcaaacg gtctctgtcc cgttctggat 1980241 ctaacacgta aaatgccgcg tctaccgtgg cttctgtcgg cccgtagcca tggattaatg 1980301 atacctgcgg caatacagaa gcaaaacggg ctgccgtacg cggcgcaagc ggttcacctc 1980361 cggcgaatac acgctttagg cttgtcctgt cactcagcct ttcgatttcc gcttgatcga 1980421 gaaagctgtt cagcatagcc ggaataaaat gagccgttgt cacgttttcc tgatgaatgg 1980481 cttgtacgat caatgcggag tctttttccc agccgggcgg aagcagatac gccgaagcac 1980541 cggaaagagc ccaccaaaac agctgccaca cagacgcatc aaaggaaaaa gaggttttca 1980601 ccatgacaat gtcatcttcc gaaagccgaa actggtgctg catgccggtc agaaaggaaa 1980661 cagcctggcg gtgctcaacg gccactcctt tcggctgccc ggtagagccc gatgtataga 1980721 tgacataggc gagagatccg tcgctaacag aagcagacac atgacgtttt acttcttcac 1980781 actcaagaga tgtcatgtcc acttcaagcg tttcgccaga aaagtttggt gcggagcatc 1980841 ccggctgtgt cagcaagagc gatgccccgc tgtctttcag catgtagctc agccgctcct 1980901 ttggatacgc aggatcaagc ggcaaatacg cccctccggc cttcaataca gcaaggacag 1980961 cgatcagcat gtcaggtgag cgttcagaca ggacaccgac gatactttcg tttgtgacgc 1981021 cgcgtgccgc aaggtgcgca gccagccggc tggcgtacat atcaagctca gcgtatgtca 1981081 gcgaaccgcc tgaaaagcga atggccagcc gctccggtgt gactgccgcc tgtcgttcaa 1981141 acagcccatg cagggttggg gcttcaggtg aaacagatac tgtcctgtta ttttgagaaa 1981201 cgattttccg tgttttgtcc tcatctagca acgtcatctt tgacacagga agagatggat 1981261 cagagatgac gtcagagacc atgtgcagca aataatcttt tatttcggac atcatgcttg 1981321 gttgataagc gctggtctga aaatgaatcc gaacgtacaa ggtacggcct gggatcactt 1981381 tgacactgca actataattg gtcacctctt ccatctcaaa atctttgacg gagaaatcaa 1981441 atgaccccgc ttgattcagc tcttcgatct cttgctgggt aggtgtattt tcaaagacga 1981501 taatatgatc gatcaactct tgctttagag cactctgcgc ctgaatatca tacaagggaa 1981561 agtaactata ggcttctgcc tcattcatgt ccttttgcat tctcctgact aggtcagaaa 1981621 aagacagaga atcactttgg gctcgaatag gaatggtatt gataaaaagc ccgaccatgt 1981681 tttccacatc ttttagctca gaaggtctgc ctgatataac tgaaccgaac acagcatcgc 1981741 tgctgcgatt gaccttttga agcataatcc cccataaagc ttggaaaaca gtgtttagtg 1981801 tcgcaccaga agctgctgcg attttctgta attcggcggt ttctttttcg ggaatggcaa 1981861 acgtgatctg ctgtagtgtc ccattcggaa tttgatctgt tcttttcggc aggggtgtag 1981921 atttttcgaa atgctgaagc ctctttttcc agtactcagc tgcttcttca cgatcttgct 1981981 gcatcagcca tttaatatac gtcccgtacg gctgtacggg aggcaaatca ggaagctggc 1982041 ctttacccag cgcttgataa atatggagaa agtctttaat gacgatgcct aaacaccagc 1982101 catccattaa aatatgatgg tggctccaga tacagacata atgatcaggc gcccatttta 1982161 aaatagatat tctcatcagt acatccgttt ggagatcaaa gcctttggat ttgtcctgct 1982221 ctttgaatgc ctcggtacaa tgttctttat ccctttcatt gagatgggaa atatcttcaa 1982281 tatgaatagg gcaatgacgt tgcttgagca cgacttgacg aggtttggct acatttttat 1982341 agatgaatgc tgttcgaaag atatcgtacc tgtcaaaaac agcatccata cttttttgga 1982401 aacgctccaa gtcaagctgt ccatggatcg taaaagaagc ctgttcaaaa taagctctcg 1982461 actgttcatc atacagtgag tgaaaaagca tcccttcctg cataaatgac aaagggtata 1982521 tatcctgtat ttcaggttgc tgcggcatca gtgaatctcc tctcctatag tttgttgacg 1982581 gctcccatga tctcactcaa ttcatcaagc gttaagtctt catcagtgaa atcagatgcg 1982641 ctccactctt ggttttcttt gccggtacaa tgctcaatga tgttttccag agtctgttta 1982701 aaatgcctgg aaaatgtttg gattgttttt tcctcaaatt gaaacctgtt atagatgatg 1982761 tgcatgttca ggcaccccga agaaacggcg ccgctgatat ccagtgcata aggacgctcc 1982821 cagttcgggc tgatctcatt tcctggcttg atgtcagaca cctcaaaggc atttgattga 1982881 atatcctgat caaactggcc taaataatta aagctgattt ctgggctgtt tttctgagag 1982941 ccccatcttt tgctgatata tttcagcacg ccgtagcccg cgcctttatg cggtatacgg 1983001 tgcagcatat cttttgtctg tttaataagg tggcccagcc gctcttcttt gtccttatga 1983061 tcggaatctc tcatatcaag ccacacagga taaatggagg tgaaccagcc aacagttctg 1983121 ctaatatcga tgtcctcaag atatgattcc cttccatggc cctccatgct gattttaaat 1983181 tggttatttc ccgtccattt ctgcaaagca agacctaaag ctgtcagaag gatatcattc 1983241 atctccgtgc tgtaagcttt atgtgcagcc gttaatagta attctgtgtg atggcgagat 1983301 agctcaaaat caatcacttc tgtatctttg aatgtgttag atgctgcgtc attgtctttt 1983361 ggaataggct ggatgtgacg gttctcgcac tcatcccagt acgctgcttc gcgctgcacc 1983421 tggcggctta tagagtagtc agctattctt tgtgaatacg ttaaatatga atctgttttt 1983481 tgcggcagtt taatagattc tcctgagact gcctgtttgt aagctgttga aaaatcctca 1983541 aacaaaatgc gccaagaaac cgcatcaaca actaagtgat gaatcgttag aaataaatgg 1983601 tcaccattct cggttctaaa caatccagcg tgaagtaagg ggccggtttc caaacgaata 1983661 tgttcttgca tccggctggc tgcttcctca atcgtgttcc gggcttctgt taggctatcc 1983721 tttacatcaa acagttcaag tgcatatagc tcctcatctg aaagatctat ccctctgttt 1983781 atctgcactt gcctgccatc ttcatgccgg catacgattc tcagtgcatc atgatgagtc 1983841 acaaggcttt ttagtacttt tctaagcgca gcctcatcaa atcgttcagc ccggtagatc 1983901 ataacggatt ggttaaaatg atggctttcc agagattgcg agaaaaacca ctgctggata 1983961 ggtgtccaag taatctcgcc ttcgaccggg ccttggtcaa tggcgcgtac gtcttttcga 1984021 acccgggcgg acagttcacc aagagtctga tgttcaaaca tctcacgtac tgtcgtttca 1984081 aatccgcgct gcttcagtct ggcacaaacc tgcagcgctt taatagagtc tccgccaagc 1984141 ttaaagaaat tggcgcttac acccagctca tctacattaa gaagctcttc ccaaatttca 1984201 gccatcaccg tttcaatctc atttctagga ctgatatcat cagctgtata agcttgtttt 1984261 tcaggctctg gcagggcttt ctgatcgagc tttccattaa cagtcaccgg gatgctgtca 1984321 atttgtatca tacgggcagg cagcataaag tcaggcaagg cgttttttag gtaagttcgg 1984381 atgtctgata tattcgcagc ctgttgatct tttatcacca tatatgcata tatagctgtt 1984441 tgcccttgct cgtctgctct ggtaatgaca gccgcctctt taatcattgg atactgaaga 1984501 agtgccgctt ggatttcgcc taactcaata cggtgccctc tgactttcac ctgctcatca 1984561 atgcggccta agtattccag ctcgccattt gacaggcgct tagcaagatc tcctgttcgg 1984621 tataatctgt ctcccggaag ataaggattg gatacaaaac ggtcagcggt cagctcatct 1984681 ctgttgagat atccccgtgc cacaccttcg ccgcctatat acagctcccc tggaactccg 1984741 gtcggctgca ggttcatatg ggcatccatc acatgagcct gcagagtaga aagaggccgg 1984801 ccgatattgc ttttattttt tgcaatgtct gctgcggaca attttttgaa tgttacatgg 1984861 accgttgttt ctgtaatacc gtacatatta atcaaatcag tatgaggata tttttcattc 1984921 cagctttgaa gcaatccggg ctgtaaggct tcgccgccaa aaatcacata gcggatgttt 1984981 aaatgatctg tatgattttg gtcttcaagc atcaagccgt aaaaagcagt cggggtctga 1985041 ttgagtacag tgacgcgctc tttttttaac aataatcgga atgcttgggg gtcacgggct 1985101 gtttctttag agaccacgac taatgtactt ccgttcaata acgcaccgaa catctcccat 1985161 acagagaaat caaagcaata agaatgaaat aacgtccaga cgtcttcatg gttaaattca 1985221 aaaggcaggt tttgatgctt caagagactg atcacattgc ggtgctcgac aatgactccc 1985281 tttggctgac cagtcgttcc agatgtgtat atcacgtatg cgggctgatc cgttactatt 1985341 tcttcaatgt ttacatcagc cggaattgag ttgttttcac attcatcgat atacaaaata 1985401 tgcccggtgt agtctgcagg tttgtttaga ccgcgctctg tcagcagcag ttttgctccg 1985461 ctgtcattga gcataaagct aatacgctcc ttgggatatt caggatcaat cggcaaatag 1985521 gccccgccag cttttaaaat cgataaaacg ccaatgatca tatcaggtga ccgatcgagc 1985581 atcagaccga cgatatcgcc agttctgacc ccttgtttga tcagcatagc agctgcccgc 1985641 tcggcttttt cattcaggtc tcgatacgta agctgagaat ggccgcacac cactgcgata 1985701 tgctccggat actgagctac ttgcttttca aataagctta ctatgttttc atttctcgga 1985761 taagctgcat actgccccat tttttcaagg agtaacctac gctctgcagc aggaagcaat 1985821 tgcatgttcg aaattctcat ctcagtatcc gccgttaccc cttttaccaa ttcaataaaa 1985881 taggatgccc actgcgtaat ggtttcttct tcaaaaagag cagtgctgta ttcaaaacgg 1985941 cagcgtattc cactcagatg ctcctcagca tgtaatgtta aatcgaattt agatatatca 1986001 tgtttaggag tgacagacga aatcgacaga ccaggcactt cgaaccggaa atcttcactg 1986061 ctttgaagca caagcatcgc atcgaacagc gggttgcgat ttacctctcg atttgtatcg 1986121 agcttatctg ccagctcctc aaaaggataa tcctgatgct cgtaagcggt cagagccagg 1986181 tggcgaatgt catgcaaata ggagctgaac gttttgtggc cctcgggctt gctgcgcatc 1986241 gccaatgtat tgacgaacat tccgatgacg cgctccagat cagcgtgcgg tcttccggca 1986301 gcaggcgaac cgacaacaat atcctcttgc ccgcttagct tagataacaa aatagaatag 1986361 acagccagaa gaatcatata caatgttgtt cccgtttcag ccattaaacg gtgcagttca 1986421 tcagccatgt ctttatcaat gttgacttca attgttccac ccctgaaatc agggagacgc 1986481 ggccttgttt tatcaagcgg taattctagt gtaggaagac tcccgccaag ctgaccgagc 1986541 cagtaggcct cctgtttttt gtatagctct ttcgggtgct tctcttgctg ccaaacagca 1986601 aaatccttat aatgcaggtt taaagctggc aactcttttc cgcaatataa gtcagtaaat 1986661 tcttggacaa gagtgctcat cgagacaccg tcggcaataa tatggtgcat atcgagcagc 1986721 aaaaagccgc gattattgcc cattgtaatg acacatgctc taaaaagcgg accggatgat 1986781 agataaaacg gtttgataaa ggtctcgatt gcagactcaa gcatttgttc tgattccatt 1986841 tcaagctctt ttagatcaaa agccatctct ggataaatga tctgcacagg ctcgtctctg 1986901 tcaagcacaa aaacagtccg taatgcttca tgccgattca caagttctgt gagaacgctt 1986961 ctcaaccgct ggcgattcag atttccgcgt aattcaagta cagctggcat gttgtagcct 1987021 gtgctgtcat ctgccagctg atgaagagca tataatcgtt tttgcgagaa agacagcgga 1987081 tagacatctc tttgatccgc aggttcaatc tgtgtaaaag cgtgttcttt taagctcatc 1987141 aatttgaccg ccatgctttc aaccgtcgga taagaaaaca cctcactgag cggcagctcg 1987201 acattaagct ttttatgtat tcttgatacc agtgcggccg cttttaagga ctgtccgcct 1987261 aactgaaaga aatcatcacg aatgccgatg tgctgtttat tcagcacatc ttcccaaata 1987321 tgtgcgagat cagcttcgat taaggttcgg ggcgccatat atgtgacact cgtattgttt 1987381 tctggttcag gaagcgcaaa cctgtcaagc ttgccgctgg atgttaatgg catctggctg 1987441 atgttgataa tacttgctgg gatcatatag gacggcaatg tcccggcaag atgctgatac 1987501 aaatctggga ggctgtttcc cttttccgga acgatataag caacgagctc cttttcctca 1987561 gcagaaacat cacgggccag taccgctgct tcttttaccc ccggtgcttg tcgaagaact 1987621 gtttcaatct ctctcagttc aatacgataa cccctaattt tcacttgatc atcaaaacgt 1987681 ccaatatatt caatcgttcc atcaggcaaa aagcggcctg catcacctgt tcggtataaa 1987741 cgctcccctt caaggaatgg atgatcggag aatgctttct gtgtcagctc ttgctgtttg 1987801 tagtatcctc tcgcaagacc cgcgccggaa atacacagtt cacccgccgc gccgatcggc 1987861 tgcatttgat ttccgtgcaa aacaaatact tttgtgtttc tgatcgggtg tccgatcgtg 1987921 atcctctctt ttttattcag atgccgcaat attgttgttg ccacactgtt ttctgtgggc 1987981 ccgtattcat ttgccagttc agcagaagga caaattattt gattcaactc aagcagatca 1988041 ggcgtgaccg cttcacccgc aaatgtcaca atacgaagac tttttgcatc gtcagcagtc 1988101 atcacttcca ataacaccct gtacagggaa ggaacaatga tcatgtggct gaccttataa 1988161 cgggctattt ttcgcttaag ggccagcaca tccttcgctt cgtcatctgt tgtcagcagt 1988221 acgcacgcac cagataaaag cggggtaaat aagctcgtta cacagccgtc aaacacgtac 1988281 gaaaacaaat ggagggatat atcctgttcg gtcatgctat actcttcccg tctccattgc 1988341 aatgtattgg caataccgtg atgatcaact aaaacccctt tagggcgccc cgtcgttccc 1988401 gacgtataga tcaagtaggc tagatcacct ggcggcatat ttggcgcttc tgtttggtaa 1988461 ctttctgtat gttctatcgt tatcgtattt ccttcatagg acggagggat caaggaaata 1988521 aggtcttctt ctatcagcaa ttgagccgct tgactgtcct tcagaagaaa agaaagacgt 1988581 tctgctggaa aatgtggatc aagcggcata taagcgccgc ctgctttcca aatcccaagc 1988641 agagctgcag gcatttccat tgaccggccc atcattacag caacgatatc cccagatcca 1988701 acgccttttt ctatcagggc gtgcgcaatc tgattggctc ttacttgtaa ctggcgatag 1988761 gtccagcact cgtttcccat tttcaatgca gcagcttcag gtgttttgtg agcttgttcc 1988821 tcaaacaatt ggggtatcgt tttgttcaca taaggacgct cagtttcgtt aaacaattgg 1988881 ataacctgtt gctcctccgg cggcacgata ttgatgtcac tgacggcaac atcgggattt 1988941 gtcaaaatgc aatccagtgc ttgctttaga tgcccctgaa tcctcagcat ctcctcccgc 1989001 tcgtaaacgt ctgcgttgta gctgaatttg atataaaatg attctcccgg aacgataacg 1989061 atattaaagt cgtaattggt ttgttccgac attgaaatgt cactcagctt cagagcgcct 1989121 tcgtcatttt cactctccac gcttaatgcc tgatgaagct gtacagggta attttcaaaa 1989181 acaaaaatat gatcgatcaa cccttgcttc aatggactat ggttttgaat ctcataaagc 1989241 ggataatacc catgctgttc agatgataaa atatcctcct gcacggcttt gaccagcgaa 1989301 gaaaatgtta tgccttccgc agatcggatt cgcactggaa cagtattgat aaacaaaccg 1989361 accattgatt caatcccgtc aatcgctgac gggcgtcccg aaatgacgga gccaaaaacg 1989421 gcatcatctg cagcattata tcgatggagc agcacgcccc aaatactcat aaacagcgtg 1989481 tttaatgtca ctccccagtt ttgggcagcc tctgtcagtt tctcaaccat atccggcgct 1989541 aatgaaaagc tgacctggtc ggctttataa ttcccgtctg ccgtgcggcg ctttattcgg 1989601 ggaatagaag cagtattgcc gtactccttc aaatattcgc tccagtaggc agcagtctct 1989661 tcttgatctt gttctccgag ccattcaata taacggctgt acggcaccgt gctgccaagc 1989721 tgtacaggtg agttattttt gagcgaatca tacatgctga aaaactcttt aagaataatg 1989781 ccgagacacc acccatccat gatgatatgg tgatgtgtcc agacacatgt atattggctg 1989841 tctcctctat caaaaagggc aagacgcatt aaaggatctt tttgcaaatc aaatcctttt 1989901 tcccgatcct tagtcataaa agcatcaatc agcgtctgct gttcttgatc agccaggcga 1989961 gaaatatctt ctctatatac tgtcaattca cggtttgata gaactacctg ctgcggacct 1990021 gtaagatctg gtacttcttt aatgaaaatc gttctgaaaa tatcatatct agaaacaaga 1990081 aggtttaagc tcttttgaaa cgagtcgacg catagattcc ctgtgatcgt aaacgaggtc 1990141 tgttcgatat atgctttcga gctgaaatcc attagtgaat gaaacagcat tccttcctgc 1990201 atgtgcgata acggataaat atcttgaatt tgtgccgatt gtgccatcaa ttccacacac 1990261 cttttcaaaa gttaaagatc tttcacgaga tcttcgatgc tagataatgc agacaacgtt 1990321 aattctttat tgctgaaatc gctcaatgtt ttttcgcgtg cttttttctg cgaacaatgc 1990381 tcaatcgtct cgataagatg cctgtgaaaa cgatccataa agcactcaat tgagtgtttg 1990441 ctgaacactt gggtgtatac cgcttttacg tgaagccgtc cgtccgtaat gagagcattg 1990501 atgtccagct catactctcg ttctctctca cccgctattt cgtaacgggg ctggtaatat 1990561 gataattgaa acgtttcaac ttccttctct tcgctaaatt gaccgagata attaaagctg 1990621 acctcaggct ctttatgccg cagttctcct atgtgtgtta acaatccgta tccagttcct 1990681 ttgttcggta ctcttctcag catatctttt gtcgtcttaa ttcggtatgc gagctgatcc 1990741 tcgaaaggct cgggaatacc catgtctagc agaataggat aaatggaggt aaaccatcca 1990801 actgtccttg aaatatcaat gtttggcaca tgcccttctc taccgtgtcc ctcagtgctg 1990861 atcacgattt ggtcatgccc agtccattca gaaagcgcca ttcctaaagc cgtaagcaaa 1990921 agttcgttgg catcagtacc ataggcttgc tgggtttcaa acagcaattt ttcagtccag 1990981 tccccggata gtacaaacgc tgctgcgtcg ctgttcattt ggagtttgtc tggcacattt 1991041 tctatgtcct taggaagaaa agcagtgtga gcgtctaaaa tcgtttgcca atacgttttc 1991101 tctgaaagca attgtttact ttcagctatt tgggtaagac catcggcgta ggataaataa 1991161 gaatccgttt ttggcggtaa ttggatttct ttcttttcta aagcctgttg atatgctgca 1991221 gctaaatcct caagcagaat tctccaagaa acgccatcta tcacaagatg atgaagtgca 1991281 atcagcaaat gatccccttc tgccgtttta aacaaacctg cttgcagtaa gggccctttt 1991341 tctacattca ttttgctttg aatgacggtt tcctcagcgg caagtttttc atcaagatga 1991401 gccctttcca gcgatgcttt tgtccaatct gaaatataaa ggccaaacag ttcatgatcc 1991461 ttgtgattga ttccgcgatt aaactgaatg acatggccgt tttggtcacg ttggaaaatc 1991521 atgcgaatgg catcatgatg ctcggttatt ttacgcagcg ctagatgaag cgcgttagca 1991581 ttgaatcctt tttcactgaa aagcatgacg gactggttgt aatgatagtg aaaagcatgt 1991641 acctgtccga aaaatcttcg ctgaatcggg gtgagttcag cttcaccttc cgcaggtccc 1991701 tggtccgctt gagatgccaa tggtgtgata tgtccgcata gttcctgaat cgttgaataa 1991761 cggaataagt cgcgtattgt catgctccag ccttcagctg ccagacgtgc tgccacttgt 1991821 aatgctttaa ttgagtctcc gccaagctca aaaaaggaat cgtgaatgcc gactcgtgac 1991881 atgctcagta catcttccca tatatacgcc atcgtttttt gtaagtcgtt aactggtgcg 1991941 gtatatggac gcgataacac attatttgga gccggcaagg catttctgtc cagctttccg 1992001 tttagggtca gcggcatgtt tactaaagga atcagatatg caggaatcat atacgctggc 1992061 agttcctttg ttaaagcagc acggagagca ttcgtattga cgtctgaagg cacaatatat 1992121 gctgccaaac cagcctgtcc atttttatca tgctgaacgg caacagcagc ttctctgaca 1992181 agccccgttt gaagcagaac actttcaatt tcttctgttt caattctgta tccatttatc 1992241 tttacttgat aatccattcg gccaagaagc cggatcgttc cgtttggaag ccagcatgct 1992301 cgatcaccgg ttctgtacag cctttctcca gagacaaatg gattttctgt aaatttcatt 1992361 tgcgttaagt caggtttatg atgatagcct ttcgcaacac ctgccccgcc gatgcacagc 1992421 tcgccggcaa caccgatcgg ctgaatttga tcagtctggc tgagtacgta catgtgtaca 1992481 ttcggcagcg ggctgccgat tggtacgtta tctcccgtac actctccacc catactggtt 1992541 tcatagaaac tcgaatcaat ggttgcctct gtgacaccat agctattaat gatgcgcatg 1992601 ctttggccaa agcgatctgt caatgttttg aaatcttgag ctttcaccat gtcggaacca 1992661 agaatcagta tgtctaagtc aggaagcttg aactggttac ggtatacata ctccatcacc 1992721 gggataatga gagccggtgt cgactccatc accgtgattc tctgagattt aatgatttta 1992781 tatatttcag caggttccag ccgtgtttca tctgggcaaa cgattagagt cccgccgttg 1992841 gtcaatgttc tcgccaaatc tcctgagaag acatcgaatg aaaagctcgc gatttgaagc 1992901 agtctgacag gcttccgatc cagttcataa atttgacgcc aagcaagagc agcatgagta 1992961 aagttctgat aggtgacaat aacaccttta ggcgcacccg tcgttcctga cgtataaatg 1993021 atatataccg gctcttcagg agcaggagat aagttaaggt tgcagttact ttcttcaaaa 1993081 gagccctcat cgtcaaggaa gatgtgagac atctcagatt caggcgagtt cgaaatcaaa 1993141 tgcttcaact ctctctgtaa aagaagaata tctgccccgc tatcacgaag aatgtattca 1993201 atacgagctt ttggataatg tgcatcgatt gggatataca ctccgccagc tttcatcact 1993261 gccagaactc caacaattgc atcgatggac cgcttggcta aaacagccac agttggcttc 1993321 ggtccttttc tgttttgcaa tgttcgtgcc agacgattgg ctctttcatt tagaaggcga 1993381 tagctaatct ctgtttcgtt atcaataaca gctatatgtt ctggattttc ttcagctttc 1993441 gcttcaaata tgcgatgaaa aggaatatct ttttgagcaa attcaacttg agttttgtta 1993501 aattcaaaga ctattttttg tttttcttta tcactaagta tgtttatttg tgcaaggctt 1993561 gtttcaggag ttgaaagtgc ctcatgcaga aattcgataa aatgatcagc ccagcgttca 1993621 atcgtagctt tcaggaatac ttctgtacta aattccattt cgcagcaaat agatccactt 1993681 atttccgtag ctattaatgt gatatcaaat aaggaaatgt gatgtgcgaa attggcaggc 1993741 cggactttta tttctctcag atctatgtct tgtttttcca cattttgaag gataaacatc 1993801 gcatcaaaca ctgggttccg gctcatatct cgtgtcaatt caagcttatc gacaagctct 1993861 tcgaacgggt aatcctggtg ctcaaaggct tccaatgctg tctcacgcac ttcctgcaaa 1993921 tactgtacga atggcttccc gccctccggg cgcgtccgaa gcgccagcgt gttcacaaac 1993981 atgccgagta tcggctcaag atccttgtgc ggccggccgg caattggcga gccgacgatg 1994041 atatcttcct gtccgcttaa gcgtgacaag aacgcggtgt aagccgcaag aagcaccatg 1994101 tacagtgtgc ttccgttttc acgtgccagc ttgtgaaggc ctgatgcaac ctcttgatcc 1994161 agcgtaaatg agaccttgtc acccgcgaag cttcgcaccg gcgggcgggc atgatcagcc 1994221 ggaagatcca gcacaggcag ctcgccctcg agctgcttca gccagtacgc ctcttgcgtt 1994281 ttgtacgcgt ctcctgtttt gaatccttct cgccatacgg cataatcttt atattgaatg 1994341 cgcagtgccg gaagattccg attattgtac agctcgccga attcccgaat cagaatgttg 1994401 acggaaacac cgtctgaaat gatgtgatgc atatcaacca gcaacaggtg ccgctcatct 1994461 gatatcttta cgatttgggc acggaacagc ggcgcttggc tgagatcaaa cggtttgata 1994521 aatgcggctg cggcctcctg ttcggttcgt tcgccgagaa ctgtagtctg taacgtaaac 1994581 ggcacctcgt catggatgcg ctgcaccgga tcgcctcctg cgtcctgttc gaaggaggtc 1994641 cgaagcgact cgtggcgctt gatcagctct ttgaaagctc tctccatcct ttcagggttg 1994701 agcttccctt cgagctctaa cacagccggc atattgtagc ctgtccctcc gtcctccagc 1994761 tgctgaagga cataaatccg cttttgggca gaggaaaccg gataggtttc ctgtttttca 1994821 gcgggcttaa tcgcttcata tggactgtcc gttccttcac ggataacggt agccagtcct 1994881 tctactgtcg gatgggcaaa cacatctttt agcggcacct gtacatcgaa ttctttggcg 1994941 atccgtgaga caagcgccgt tgcttttaag gaatgtcccc cgcggtcaaa aaagttgtcg 1995001 tgaatcccga cagggccatt tttcagcacg tcctcccaca gctgagaaag cttcatctca 1995061 gtcacgtttc tcggcgccgt gtaggtctcc gcatctgccg ctccgccagg agctggcagg 1995121 gcgtttcggt cgagctttcc gcttggcgta accggccact gttccatctc tatcatatag 1995181 gctgggacca tgtagcccgg caacagtctc tcaagctgtg cacgcacttc gtttctttgg 1995241 agcccttcta cataagcgca taattccggc tccccgctgt ctgtccgtac ggtaacagcc 1995301 gcctctctta cgccttctat gcttcttagt gccgcttcaa tttctcccgg ctcaatccgg 1995361 tagccgcgga tttttacctg atcatccgtg cgcccgagga attcaacatt cccgtcaggg 1995421 agccagcgcg ccacatcccc ggttttgtac atgcgttccc ccgggtaaaa cgggtcttca 1995481 agaaaacgct cctccgttaa tgccggccga ttcaaataac ctctggcaac acccgctccg 1995541 gcaatgtaca gttcgccggc gacaccggaa ggctgtacgg ctaaatgcgg atctaaaaca 1995601 tacaaacgcg caccaggtac gggcttccca atcggaatcc gcaaacgatc cctgtcccgt 1995661 tctggatcca atacgtaaaa tgccgcgtct accgttgctt ctgtcggccc gtaaccatgg 1995721 attaatgata cctgcggcaa tacagaagca aaacgggctg ccgtacgcgg cgcaagcggt 1995781 tcacctccgg cgaatacacg ctttaggctt gtcctgtcac tcagcctttc gatttccgct 1995841 tgatcgagaa agctgttcag catagccgga ataaaatgag ccgttgtcac gttttcctga 1995901 tgaatggctt gtacgatcaa tgcggagtct ttctcccagc cgggcggaag cagatacgcc 1995961 gaagcaccgg aaagcgacca ccaaaacagc tgccacacag acgcatcaaa ggaaaaagag 1996021 gttttcacca tgacaatgtc atcttccgaa agcggaaact ggtgctgcat gccggtcaga 1996081 aaggaaacag cctgacggtg ctcaacggcc actcctttcg gctgcccggt agagcccgat 1996141 gtatagatga cataggcgag agatccgccg tcagcaggag taaactcatg gttttctgct 1996201 ttttcgctcg caagagatgt catgtccact tcaagcgttt cgccagaaaa gtttggtgcg 1996261 gagcatcccg gctgtgtcag caagagcgat gccccgctgt ctttcagcat gtagctcagc 1996321 cgctcctttg gatacgcagg atcaagcggc aaatacgccc cgccggcctt caatacagca 1996381 aggacagcga tcagcatgtc aggtgagcgt tcagacagga caccgacgat actttcgttt 1996441 gtgacgccgc gtgccgcaag gtgcgcagcc agccggctgg cgtacatatc aagctcagcg 1996501 tatgtcagcg aaccgcctga aaagcgaatg gccagccgct ccggtgtgaa agctgcctgt 1996561 cgctcaaaca gcccatgcag ggtgaaagct ttaggcgaaa cagcttccgt cttgttaaac 1996621 tcatacaaca atttttgctt ttctcttgta ttcgtcatat ctaattctct tataaagctg 1996681 tgcggatgtt taagggcgtt ttccagtatg gtaagcagat gagattgtat tcgtttaata 1996741 tcctcaagag aaaacaaggt attttgatag tcgaaattta attgaatggt tccattgtct 1996801 atccgttctt gtatttgaac tgaaagttcg ttcgcggtgt atccgctgaa ataaagcgct 1996861 gtttcatagt caaaatcatc tgcattgtgc cactgaagtg gctgatactg catagatata 1996921 ccgataaggt tgtgtaaatc cttctgttca tttcttaatt catttacaag caaattataa 1996981 ggaaaccgtt gatgacgcat aacagaaagc tgttccctgc ctattgtgcg gacaaaggaa 1997041 agaaaatctg tgtcaggatc aaccgttatt ctgattggaa gggaactaac gaacatgccg 1997101 agcatttctt tttcagcctt tgaacctctg ttgccatagt aggtgccaat ggcaagatct 1997161 tttttagaag tgattcggct gatgcatatg taaaatgaag ccataaataa ggaaatgata 1997221 ttgatcttgt gttcttcgca gaagattcga atcgtttgct ctagatcagg tgaaagaatg 1997281 atggtgtctc tggatgcaga tgtgctctgt ttttgtaagg acgtctggtc ggctaacgag 1997341 tggtattcca acgggtgctc aaaggtttgc gtccaaaata aacggtcctt tgcaaaccgt 1997401 ggagattgta gatattgact ctctttttcg atgtagctca agtaagaagg ttccggctga 1997461 tcaggtaaag gatctttctt tttcattttt tgataaagat ctataatttg atttcccatc 1997521 acatttaaag agattccatc cattatgata tgatggaatt tcgcaaatag ccaaacttca 1997581 tgagagtcaa ttctaaggag gtaaaattga aaaagaggcg agttgaacag tttaaatgga 1997641 atgctcgctt gatcctgaat ccattgctct atttctatca tttcaacatt tgaaaaatca 1997701 attattctaa gtggataata tttatattca gtaaggtgca atcgaggctc aagctcttct 1997761 ccttctaaca gctgaaatct aatggcgtcg ttgcgggaga tggaatgatt cagtgctccc 1997821 tccagagtat caagctcaat attgccttta aatttcacac aagctgtaag attgcaaatg 1997881 ctggtatctg gctccagcag ttcggtaaac cacactctcc tttgggcatg ggttaaagaa 1997941 taagtatgtt cgctcaacgg attccctcca gttctcataa taagaggata agaaaatgta 1998001 gaaaaaagca gaaaaatgac aataaaagaa attatatgac tatataatcc atatatgcac 1998061 tatattaacg gatatttttt aaagtacaat aaaaaacatt aaatttttat aacatttttt 1998121 ttgaatatag tattatttct ttatttttcg tttctttttt tatcaaattt ccggatataa 1998181 agtgataaaa gtattgtttt acataaggtc ttatacacta ctttttaatc ggactaattt 1998241 tcttttgtgc atcattcttc taattgttgg aaggttcgac aaagcgttat tacagacata 1998301 aaaaaacctg ttttctcttg gaaaacaggt ctcccgctat tattgatttg ccaaaatgac 1998361 agcgatttga tcctcaatat cttttccatc ctcttcatca atcaatccat ttagaagaat 1998421 agagaaaaca agtttttttc cgctctttgt ttctgcgtac cccgatagag agcttaccgt 1998481 actgagcgat ccggtttttg ctcttacttt tccttgtgca ggagtgcctt tcatgcggtt 1998541 tctcagcgtt ccgcccacca ttctgtcagg attccccgca acaggtaaag aatttagata 1998601 agccgagaac caactctgat cctgaatgtc atataacagc tgtgaaagtt gatctgagga 1998661 tacagcatca atatgtgaga ttcctgatcc gtcccttaag acgagtgatt tagaatcaac 1998721 accaaattcc ggaagcgtac tgtttaacac ttcgagcccc ttttcccagc tcccttctcc 1998781 ttttttcact ttccccatct cttttacgag cacttcggca tgtccgttat tacttaattt 1998841 catgaacggc acaaaaagtt tcgataaagg cattgagcga tgagagagca gcacatctga 1998901 agaactaggt gcttcacccg tcttgatgtc ccctttcaca gtaatacctt gtttttttag 1998961 tgactgctta aataaatcta aggcatatcc ggcaggctcc cagacagaaa tccattcctt 1999021 tgtcttgttt gcgtcaaccg gtacgctccc ttcaattgta atcgtgtttg ttccatgctc 1999081 tctttcgatt gtgaggtctt tctctgaacc ggcagcagtc gttttagcat cgttctttat 1999141 cgttatataa tcggttttcg gagagacaga cacggcaggc tcttcccctt ctttttgatt 1999201 tggggtgacc tcaacaatca cagtgcctgc atcatagtct tcgtttggag acgctgttag 1999261 agcggagatt ggcgcgccat aatatgtgta ttcatcgctc caaggcatat caggtgataa 1999321 tcgcatgtca tcatgccacg tatcatcacc gatcagattg cctttaatta cttttacgcc 1999381 ggaatgtttc aatatctcag ccattttgtc aaaatcagat ggtaaaagtg tcggatcgcc 1999441 tttccctttc aaataaaggt taccattcag ctttttccct ttcagtgttc catccgtccg 1999501 gacctcggtt gtaaaagaat agttctcgcc aaggacagaa agtgccgcgg ccgctgtcaa 1999561 aagctttaga gaagaggcag gcctcattcg ggtgtctcct gaatgttcat atagaacagc 1999621 acctgtttcc gcagagcgaa cggtgatgcc ggccattgcg ccttcgaggg caggatgatc 1999681 agctaaaatc ttatcgatct gcccggaaag tgcatcttgt ttttcagcgg caagcgcagc 1999741 ctgatgcata taaggcaccg aagcaacgac gaaaagcagt aaaacagcaa cataaagctt 1999801 tatgcttttt ttcattaatt tccccgcctc tctgcgcttc atcattggct attgatgatt 1999861 cagttcaatg gtgatactgc ttttagctgt cgtttcttct cccggctcca gcacttgtaa 1999921 accagtgagt gacgaaggta aatcaagatt cactgcgttt gtcacccatg tgtaaggctc 1999981 agggcataaa tacccttgtt ttccgtccgc attgtataca acccaatgtt taaactgttc 2000041 atctgcctta taaataatgc tgatatgtgc atgctgatga taaatgactg cctggttttc 2000101 tccgcccctc ttctgataag aagataaaaa gacatcatcc agctgcttgt ggcgcaaatc 2000161 cattccttca tgcaaagctt ctttatacgg gacatccatc agcttcccgg tcggcagcag 2000221 gcgttcatcc aactcccatt gctgatctgc tgtcagggag aataacgagc tttctgccgg 2000281 aaatataaat gtagtatgat aaccaattcc ccaaggaaac gcttcctttc ctttgttcat 2000341 gaccgtcgca tgtttaaata gggtattctc cttgatcgtg tatgtcatcc gaacgacggc 2000401 atgatgagga aattgcttct gcacatgggg aagctcagaa agatcaattt ctgtttcaac 2000461 aatcactcct tcatcagttt gcttcgtggt cacgacattc cacttttcat ggtaaagaaa 2000521 cccgtgaaga tggttgtgtt tatccttctc gttgatatca aaatgatacg ttctgccccg 2000581 gaaactgaat gtaccgtcac ttatgcggtt aggcgggaac aggattggaa tgccatacaa 2000641 tgttggtgtg tcgtgaaaac tttctgctgt ttccggttca cgcaaaagct ggacatttgt 2000701 tgttttgtcc acgagagaaa tgacgttgct cccccactca gggacaacaa tcatttctag 2000761 atgttcgttg cccgctttga tggccggcgt tcccaaatac gtgattttct caataaagtt 2000821 tgccatgttt actcaacctc tccttgattc attgctagta taagaattca atgtactgta 2000881 ccatatttcc tccattttat attttcccct atcaaataaa aaaacaccgt tcaaacttat 2000941 gaacggtgtg attcggaggc tattggatga gacgtgtgat ttgtttcttt ttccagacga 2001001 attgataata cccataaatc aacagcaagc tgacggcaaa cgcagctgga taaccaaccc 2001061 agacgccgag tatttcaagc tttgtatagt gagaaaggac gaaagcgaca ggcacctcta 2001121 ctccccagat tgcaaaaata ctgatgacgg tcggccataa aactgttccg cttgcccgca 2001181 tcgttgcaga aataatttgg gcatttccaa acagcaaata gctccacagt gtaatcatca 2001241 aaagacggtg cgcaatgtaa agcgtctctt gctcggttaa aaataacgat aaaatctgat 2001301 gtgaaaaaac atagatcaga atgatcagta cgccgccaat gatataattc agccaaatcc 2001361 caacgcgaat gacctgcttt aagcggtcaa actcgtttgc tccgatcgat tgcgcagcga 2001421 aaatagaaac cgcaatacca aggctgacgg ccggcatctg tacatagctg gccacctggt 2001481 tgaccactcc gtatgcagct gttgcattag agccgtaatg attgacgaat gaaataaccg 2001541 ctatctctga taatgagaca agaatcatat tgatgcttgc tgggacccca agacgcagca 2001601 ggagaaccag cagttcctta tccattttca aataacgacg cactgtttta tcaaattgca 2001661 gcgggtgttt tcgctttcgt aaatacacca ttaacacgag aaaagtcgca atcgtggaaa 2001721 tgacagttgc atatgccgag ccgtatatgc ccagtttcgg aaaaccaaac atgccaagga 2001781 ttaaaacagg caaaagcgcg atgttgatga ccgtgctcac aatcagcgta taaaacggtg 2001841 tcttggaatc tcctgttccg cgcaaaaagg tagtatatgc aaaatataaa aacataaacg 2001901 gcatagcata aaataaaata cgtgcatagt tagcgctgac atgaatgaca ttttcaggtg 2001961 ttcccattaa acgaaggata tccagggtga aaatactgcc gataacggct aacacaacgc 2002021 ctaataaaaa tgtaaacgtg agtgtcgtcc cgacaacagc ctttagccgt tcctcatttt 2002081 tcgctccgta agcttgtcct atcagaatcg aacttcctga accgatccca atcgtaaatg 2002141 agattaaaag aaaaaataac gggaaaaagg atgatacagc tgccactgca tcaacaccga 2002201 gccatctgcc tacagccatc atcccgacta gctggccgac tgattgcagc acattgctca 2002261 gcagaagcgg cactaaaaag agtgacatcg accgccaaac tgatggtttg cttttctttt 2002321 gagttacaag aggttcttgt gatgtttcca tattaaagga ctcctttatt tgaaatcgtt 2002381 tttaaacatg ccctcatttt ttgacaaaaa caggatatgt aacatgttat tattcatcac 2002441 tgcacttatg aaacccttcc cgattcttct aattttacac atctttttag cttatgaaga 2002501 ataaactagc aagtaatggc gtattttttg tgagtaaaag aataaaaaat aatttatgca 2002561 aaagtattgt aatctatccg taattattgt aacatttgta acataagaga aagagatttt 2002621 gaaggagaga gcgataatga aaaaatgtct tctatttcta acaaccattg cacttattct 2002681 gtcattaagc acaaatgcat ttgcgaaaaa tacatcaggc gatttatcac aaaaacaagc 2002741 attacagttg gcattatccg ctagagaaca tttttggaac accatgagcg gccacaatcc 2002801 gaaggtgaaa aaagcagttt gcccatcagg cacattcgag tatcaaaatc ttcaatatgt 2002861 atacatgtgc agtgatctag gcactaaagc aaaagcggtg aattatttaa ctcctatttt 2002921 tacaaaaaca gcaatcgaaa aaggctttaa agattatcat ttcactgttt caaaaggaaa 2002981 acttgctgtt ccaatcggtg acggagacaa tcttttgaat tggaaaaaat caactgctaa 2003041 actgatctct aaaaaaggca gcacaatcac atacgaattt actgtcccta cattagacgg 2003101 atccccttct gcaaaacgga aagtgacatt tgtgaaagaa aataaaaaat ggaaagtcaa 2003161 tcaatttgac gcagttatat aagaaaaacg cccggtataa gcgggcgttt tttatttggt 2003221 ttgcataaag aaagacaaca ggcgaaaagt gcctgttgtc tttttgtgaa tataacgctc 2003281 taggagagat tcgaactccc gacctgcagt ttaggaaact gctgcactat ccgctgtgct 2003341 actagagctt ttggtattta tatagtagct ctgatgatca atattttcaa gcgatttgta 2003401 ttaaagccct ccaaaaacct tatatgcggc tcttgtcgta tcttcatcaa taccgatata 2003461 ccgcattgta attgatggtg atgaatgatt cagtattctc tgcagctcgg cgatgtcttt 2003521 cgttcgctga taaaaatgat agccaaacgt tttccggagt gtatgcgtcc ctatctcctc 2003581 aagtccgcac gctgcagcgg cctctcttaa aattctgtag gcctgaatgc gggaaatcgg 2003641 cttcctggtc cgcactgatt taaaaagata ttcgttttcc ttcatgtctt tcgtatactc 2003701 gtatatttcc tgtttcagcg attctaaaat aagaatcttt cttttctttt tcgttttgct 2003761 ttcagtcgcc cataaatgat ctttattttg aacgtccttc acttgcagcg gcagaatatc 2003821 agaaatacgg agcgcgctgt tgatgccgaa aataaacaga aaataatccc gcttgttttt 2003881 gttaagcaaa tactgtttga cttcttggat tttctctaga ctgcgaatcg gctgtacaat 2003941 atgcatcaaa aaactcctta aaaaccgtta tgtaacattt tgaggtctat gttactatta 2004001 tagctgaaaa acgttgaatg tcaaagtgcg gcggcgttta tgtaacataa tatacatagt 2004061 gttacataag cttttaaaaa agcttcttcc aaccttcacc ctataaaata agctttaaag 2004121 cctcttataa agcttttaac ctcttggata cttatccccc tactaatcat caaaaaacct 2004181 cttaaaatga aatctgacac tcccaatttt ctggagcttc cgcaaaaata tacaaaaaaa 2004241 gacacaattt caaattgtgt cctaatcctc atcctttaca tcaatatctt ccgggatcgg 2004301 ttcatttaat atttcctgca caagtgcttt gtaattctcc agctgttcga gatgcgtttt 2004361 gaactgttcc ttataaatca aaaattgctc cccgtcatga acggctctga ttttcccttc 2004421 gagcaccaag cttttaatat aatcctctga aagatttgta tattctgctg tttcttcaat 2004481 cgttaaatac atatagcagt cccttcttaa tccgtatgct gattctaata tagcacatgg 2004541 ctcatatcaa tataatcaat tctgcacaga aaaacggcat tatgcactat ataatatacc 2004601 atttgtcact tgtgaaaacg ctgtaatttt tttacgctaa gattgtaaca atacagcttc 2004661 atataggagg gagaacatga aaagaacgtg gaacgtctgt ttaacagctc tgcttagtgt 2004721 tctgttagtc gctggaagtg tcccttttca cgcggaagct aaaaaaccgc ccaaaagcta 2004781 cgatgagtac aaacaagtag atgttggaaa agacggcatg gttgcgaccg cacatcctct 2004841 tgcttctgaa atcggtgctg atgtgctgaa aaaaggagga aatgctattg acgcagcggt 2004901 tgccattcaa tttgcactca atgtaacaga gccgatgatg tcaggtattg gcggcggcgg 2004961 ttttatgatg gtgtatgacg gaaaaacgaa ggatacaacg ataatcgaca gccgtgagcg 2005021 tgctccagca ggcgcaactc ctgatatgtt tctggacgaa aacggcaaag caattccttt 2005081 ctctgaacgt gtaacaaaag gtactgccgt tggtgttcca ggcactctga aagggctgga 2005141 agaagccttg gataaatggg gaacccgttc gatgaagcaa ttaattaccc cttctattaa 2005201 actcgctgaa aaaggctttc cgattgattc ggtgttggca gaggccattt ctgattatca 2005261 ggaaaagctt tcacggactg ccgcaaaaga tgtattttta ccaaatggcg aaccgcttaa 2005321 agaaggagat acccttattc aaaaggattt ggctaaaaca tttaagctta ttcgctccaa 2005381 aggcactgac gctttttata aaggaaaatt cgccaagacg ctttctgaca ctgtccagga 2005441 tttcggcgga tcaatgacag aaaaagattt agaaaattac gacattacaa ttgatgaacc 2005501 gatttgggga gattatcaag gctatcaaat cgctactact cctcctccaa gctccggcgg 2005561 tattttctta ttgcaaatgc tgaaaatcct tgatcatttt aacctttcac aatacgatgt 2005621 ccgctcatgg gaaaaatatc agctgcttgc tgaaacgatg catttgtcat atgccgaccg 2005681 tgcgtcttac gcaggtgatc ccgaatttgt aaatgttcct ctcaaaggcc tgcttcaccc 2005741 cgattatatt aaagaacgcc agcaattaat caacctagat caagtgaata aaaaaccgaa 2005801 agccggtgac ccttggaaat accaagaagg atcagcaaac tataaacaag ttgaacagcc 2005861 gaaagacaaa gtagaaggcc aaacaaccca ctttacagtt gctgaccgtt ggggaaatgt 2005921 tgtttcttat acaacaacaa tcgaacagct attcggaacg ggtattatgg tccctgatta 2005981 cggtgttatt ttaaacaatg aattaacgga ttttgatgcg ataccaggcg gagctaacga 2006041 agtacagcca aacaaacggc ctttaagcag catgaccccg acgattttat ttaaggatga 2006101 caagcctgtc ctcacggttg gatctcctgg cggggccaca attatttcat ccgttttgca 2006161 aaccattctc taccacattg aatatggtat ggaattaaaa gcagctgttg aagagccgag 2006221 aatttacaca aacagcatga gctcttaccg ttacgaagac ggagttccta aagatgtcct 2006281 cagcaagcta aacggcatgg gccacaaatt cggcacaagt ccggtggata tcggaaacgt 2006341 gcaaagtata tcgatcgacc atgaaaacgg cacctttaaa ggtgtagctg attcaagcag 2006401 aaacggcgcg gcgatcggca ttaatttaaa acgtaaataa ataaaaaact gtactcgctt 2006461 caaatgagta cagttttttc atgcagatct ttaaaataaa aactgacaaa cgtctttatt 2006521 ctgctaatgc acgtctatct tcatcttttc atttcgttta tctcatcaag aaatgtctga 2006581 aacgcactcg taataaaaaa gtctttcctg tatataaaga cgatctctaa gtcttgatat 2006641 gatggtggca gctgatgaat ccatacattt gtacgatgct cggagccgtc aacagcggac 2006701 tttgggagca gcgccgtacc catcccggcg gaaacacctt ttataatagc ctccaatgtg 2006761 ccaaactcta tgattttttg attgtgtatg cctgcttcct ctagtaatct tttgaccctg 2006821 tcacgatgag aacagccagc cccaaaaaag agcatcggct gctgaagcat gtcttctgcc 2006881 gtcccttctc gtgatgaaat caaaactaat tcatcatggg agacatggag ttgtctaact 2006941 gcagcgtgtt caaccggccc atatacaaaa gcgccatcaa ctttatgatc aagaacctgt 2007001 tgaatcaaat gatgcgtatc agctgtgttc actgataaat ccacttcagg aaaacgcctg 2007061 aggaaggatg ctgcatgctc aggcagatgc gttaccgcca ttgtttccag tgatccgatc 2007121 cgcaaaggcc cttttggttg cctgctcatt cgggtcgatt tttcagcttg gtctaacagc 2007181 gataatactt gatctgcata ttgtaaaaga ttttctcctg cagcagtcag cttcattccc 2007241 cgattcgttc gatgaaaaag cctgatattc aaatcttcct caaggttatg cactctggct 2007301 gtcacattcg actgaacata attcagcatt tgggctgctt tcgttatgct tccttcgcga 2007361 gcaacagcct gaaaaatctt taaatctccg ctttccacgc gctctcacct gcttgctatg 2007421 atgaaaagtg atattggcta tcatatttgt tcattttact cgaagaaaac cgctatgtaa 2007481 aatatgtaaa gatatgaaaa tacaattaat gaggaggcag acagcatgaa agctgtaatt 2007541 cacaacggaa aagccggtct tctggggtta tcagttcagg acgttccatc aacaaagcct 2007601 ggatacggag aggtaaaggt taaattaaaa tctgcaggcc tgaatcatcg tgacttgttt 2007661 cttatgaaaa acaaatctga acaagatcct cacatgatac tgggttctga cggcgcgggt 2007721 atcatcgaag agattggtga aggcgtgaaa aatgttactg ttcagacaga agtagtcatt 2007781 ttcccgacat tgaactggga tttgacagaa aatgttccac ctgtacctga gattctggga 2007841 ggtccttcgg acggaacact tgctgaatat gtgatcattc cttcacaaaa tgcaatcaaa 2007901 aaacctgctt atttatcttg ggaagaagcg ggcgttttac ctttatccgc tttaactgca 2007961 tatcgggctc tgtttacaaa ggggcaatta aaaaaaggcg agcatctatt gatacccggc 2008021 atcggcagcg gtgtagcaac ctacgcttta tttatggcta aggcgattgg ggcaacagta 2008081 agcgtgacct cccgcagtga ggagaaaaga aaaaaggcgc tgaaattagg tgctgattac 2008141 gcatttgaca gctacagcaa ttgggatgag cagttgcagg gaaaaaagat agatgttgtt 2008201 cttgacagca taggacctgc cctcttttcg gaatacttcc gccatgtaaa accaaatggc 2008261 cgtattgtca gctttggggc aagctcaggg gataatctca gttttccggt gcgttcttta 2008321 ttctttcctc aggtcaatgt tttgggaacc tcgatgggaa gcggtgagga atttcaagct 2008381 atgctcgctt tcattgacaa acataagctg cggcctgtaa ttgaccggat atatccttta 2008441 gaaaaagcat gtgaagcata taaaagaatg caggaaggca gacagtttgg aaacatcggg 2008501 atcgtaatgg aataaaaaaa gaaaccggct ggcagccaga ccggtttctc ttatatgata 2008561 atccccttta tttacggaag aactgaactc cccatcaaat atcgatccac ttcacgcgcc 2008621 acttcacggc cttcattaat cgcccatacg attaagcttt gccctcttct tgcatcccct 2008681 gcggcgaata caccatcgat atttgtttga taatccccat atgctgcact gattttgtta 2008741 tttactgaat taacaccgaa ctgtttcaac agcggctgtt ctgtgccttc aaagccgata 2008801 gcgataaaga caagctgagc aggccatact ttttccgttc caggcagctc gcggaactcg 2008861 tattttccat gctcattttt cactttttcc atttggatgg tatgaagctc tttcagcttt 2008921 ccgtttttat ccgcgaccat ttttgtcgtt tgaatggagt attctctcgg atctcttccg 2008981 aattttgctt ctgcttcctc gtatgcatat tcaagcgtaa agacgtgtgg ctgttcaggc 2009041 cacatattgt cattcgtgcg ggctggcgga agtttcgggt gtttgccgaa ttggtgcacg 2009101 cttttggctt tttgacgcag agcggtagcc acacagtcag ctcctgtatc tccgcctccg 2009161 attacgatga catctttccc tttggcatca atgaattgct tgtctttaaa attagaatct 2009221 aaatagcttt ttgttgcaag tgtgaggtag tccattgcgt aatggactcc ttttgagtcg 2009281 cgtccttcga ttaagaggtc ccgctgtttt tgagcgcctg tgcataagat cacagcatca 2009341 aattgctcct ttagctcatc agctgtaatg tcaacaccga tttctgtgtt cgtgacaaaa 2009401 tcaattccct cttgcgtcag caatttaatt cggcgttcta caatgccctt ctcaagcttc 2009461 atgtttggaa tgccgtatgt taaaaggccg cccgctctgt ctgctcgttc aaaaacagtg 2009521 acggaatgtc ccgcttgatt cagctggtca gcactcgcca gtccggctgg gcctgacccg 2009581 acgatggcca cttttttgcc tgttcgtttt tttggaattc taggttgaat ccagccgttc 2009641 tcaaatcctt tatcgataat ggtccgctcg atgtttttaa ttgatacggc cggatctgaa 2009701 atcgctaaag tgcatgatcc ttcacaagga gcggggcata cccgccctgt gaattcagga 2009761 aagttgtttg ttttcaacag acgttccaat gcttccttcc atctgccccg gtagacaaga 2009821 tcattccatt caggaattaa gttgtaaatc ggacagccgg atgtaaatcc gttaatgtcc 2009881 gcaccgatct ggcaaaacgg tgtaccgcaa tccatacacc gcgccccttg ccgtttcgat 2009941 gcttcttctg aaaaaggagc agaatattct ttccaatcct ttaagcgagt gagagggtcc 2010001 cgctccgcag gtttttctcg tttgatctcc ataaatccag ttggtttccc catgttcctc 2010061 tccccttcct tactgtacta ccgcttgttt ttgtcccgat gctgctgtat tctgctttgg 2010121 cttcgtgttg gcctcaaaag cgaacatgat ggcttcttca tctgataaac ctgcagcttt 2010181 ttgctcttcg atgcttgcga gcatttgttt atagtttttc ggaatgactt tgacgaattt 2010241 tttcacactg tcttcccatt gatctagcag atcttctgct ttttggctgt ttgtatacgc 2010301 agtatgtctt tcaagcattg ctttgatttg ctggatttct ttctcatcct ctaatgattc 2010361 aaataaaatc atctcaaggt tgcatttgcg tttaaacgct ttgacatctt cggtcagtac 2010421 ataagcgatt ccgccggaca tacctgccgc aaagtttttg cctacatcac cgagaacgac 2010481 aacgctgccg ccagtcatgt attcacagcc gtggtcgccg atgccttcta caactacgtt 2010541 cacaccgctg tttcgaacgg caaagcgttc accagcacgc ccgttaatat atgcttctcc 2010601 gcttgtcgca ccgtaaaaag ccacgttgcc gataatgaca ttgtcatccg aagcagagtt 2010661 gaatccttct gatgacttga cgatgatttt tccgccagaa agcccttttc cgacgtaatc 2010721 atttgagtct ccgtccaaat aaagcgtcat ccctttagga acgaaagctc caaagctttg 2010781 gccggctgat ccggtaaagt gcagcttgat tgtatcttca ggaagacctt cttctccgta 2010841 acgctttgag atttcactgc cggttatcgt tccggctaca cgatttgtat tattgatttc 2010901 aatcgaaata tcagcttctt ttccagattc gatggcttct tgtacggccg ggagaattgt 2010961 tgtaatatca agtgattgat caattttatg attttgcggc gattggaacg tccgcacccc 2011021 ttcaggctga taaagaaggg tagacaaatc aagctggctt gctttccagt gctcctttgc 2011081 ccgttcactt gcatgaagta catcagtgcg gccgatcatt tcatcaaatg tcttgaagcc 2011141 taacgcagcc atgtactcac gaacttcttc ggcaatgaac agcatatagt tcacaatatg 2011201 gtcaggatct cccatgaact ttttgcgaag ctctggattt tgtgtcgcta caccgacagg 2011261 gcatgtatcc aaatggcagg cacgcatcat gacacagccg agtacaacta acggagccgt 2011321 tgcgaaacca aattcttcgg cgccgagcaa ggcagccatc acaacgtcgc ggcccgtcat 2011381 gagctttcca tctgtttcta atacaacacg gtcacgaagt ccgttcagca ttagtgtttg 2011441 atgtgcttct gcaaggccaa gctcccacgg aagccctgta tgtttaatac tggttttcgg 2011501 agaagcgcct gtacctccgt catagccgct gatcacaatg acatctgcag tcgctttggc 2011561 aacacctgca gcgattgttc ctacacctgc ttttgacacc agctttacgc tgattcttgc 2011621 gtcacggttg gcatttttca aatcgtggat cagctgggct aaatcctcaa tcgaataaat 2011681 gtcatggtgt ggcggaggtg agattaatcc gacacctggc gttgacccac ggacatcggc 2011741 aacccatgga tataccttgt tgccaggaag ctgcccgcct tcacccggct tagcaccttg 2011801 agccatttta atctgcagct catcagcatt gacgaggtaa tggcttttga caccaaaccg 2011861 tccggatgca atttgtttga tcgcacttct tctatcatcg ccgttctcat ctggaacaaa 2011921 gcgtttggga tcttctccgc cttcaccgct gttgcttttt cctccaagac ggttcattgc 2011981 gattgctaaa gcttcgtgcg cttccttact caaggacccg aatgacatcg cacccgtttt 2012041 aaaacgtttg acaatcgatt cagcggattc aacctcctcc aacttcaaag gcttgcggtt 2012101 tccgtcaaat gcgaacaagt tccgcaaaaa tccgatgcgt tcttcatcag ccgcttttgt 2012161 atactgttta aacagattgt aatcatttct gcggcacgcc cattgcaaag tatgaatcgt 2012221 tttcggatta aacgcatgat gctctccgcc atttctccat tggaagtcac ttcccggttc 2012281 aagcgttttg ctgtaatcat cctgatacgc ttcccggtgg cggcgctgtg cctcttctgc 2012341 aattgtttgt aaatcgatgc cgcctagctg tgatgcagta cctgagaaat agcggtcgat 2012401 cacatcgcgg ctgattccta ccgcctcaaa gatttgtgcg cctctgtagc tttgcacagt 2012461 tgaaattccc atcttggaca tcacttttac gacgccctca gtaatgcttt ttccatattt 2012521 gctaaccgct tcttcatagc tgatatccaa acggccttca tcaatttcct gcttgtaggt 2012581 cgcataagcg agataagggt taatcgcatc tgcgccataa ccgattaacg ctgcaaagtg 2012641 atgcacttca cgtgcttctc ccgattccac aataatgctg accttcgtac gcagcccttt 2012701 gcggattaag tgctggtgca gtgcgcttac tgccagaagc ggcggaattg gtgtcagtcg 2012761 ttcgttcatc tttttgtctg ataaaattaa caaacttacg ccttggctga tggctttctc 2012821 tgcctgtgtg aacatgtcct ttaaaccgcg ttcaagatcc tctgaaaaca gcacatcaat 2012881 tttttggctt tttaaatcag gatgaacaat cgttttcaat gcgtaaaact gttcattgga 2012941 taaaacaggt gtatacagtt taatccggcg aacatttcgt tcacttggat gaagaagatc 2013001 gccttccgca ccgagccaag tcatcgttga agtgacaagc tgctcacgaa tcgcgtcgat 2013061 tggcgggttc gttacttgtg caaacagctg tttaaagtag ttaaacagcg attgcgctcg 2013121 gtcagaaagt acagcaagcg gagcgtcatt ccccattgaa ccaaggggat ctttgccttc 2013181 tttaataaca ggaattagat acttttggat atcctcatat gtgtatccga atgccttctg 2013241 gcgagtaaga agatcactaa attgttcttc ttctcttgac tccggatcag gatttacttg 2013301 tacaagctct tcttcaagcc atttttggta cggatactca gttgcaattt gtgttttgac 2013361 ttcctcatcg gagataatac ggccttcttc caggtcgatt aaaagcattt tcccaggctc 2013421 aaggcggttt ttatataaaa cgttctcctg ttcaacttca ataacgccta cttcagatga 2013481 gaaaataata taatcatctt ttgtgacata ataacgggcc ggacggagac cgttccggtc 2013541 aaggatcgcc ccgatttgtt taccgtcagt aaatgaaata gctgtcggtc cgtcccaagg 2013601 ctccatcagg gagctatggt actcgtagaa cgcccttttt tccttggaca tatgcgtatt 2013661 ttccgtccaa ggctctggaa tgagcatcat tgccgtatgt gccggtttgc gtccagccat 2013721 cacaaaaaac tcaaatgcgt tatccaaaat ggaagagtca ctgccatcag cattgagaat 2013781 cggcaaaatc ttgtttaagt cctcaccgaa gctttcagaa acaaattgct gctcacgtgc 2013841 tctcatccag ttgatatttc cgcgaagggt gttaatttca ccgttgtgaa ccaaatagcg 2013901 gttaggatgc gctctttccc atgtagggaa tgtattggta ctgaagcgtg aatgaacaag 2013961 cgcaaaagca gaaacgaatg cttcgtcttg cagatcagaa taaaatgcat caacctgttc 2014021 aggtgttaaa aggcctttgt aaacaatggt ctggcttgaa agactggcaa aataaaaatc 2014081 aagaccttcc gttactcccc aattttcagc ctgtttacga atgacataca attttcgttc 2014141 aaaagataaa ttgtccttta gatcagaact tgcgccgata aatacctgac ggacaaacgg 2014201 acagcttttt tgcgccactg ttccgatttt tccgacattt acaggtacag ttctccatcc 2014261 aagaacgact tggccttctt gttcaattag tgcattgatt tgcttttcaa ttttttttct 2014321 ttcatcttcc ttctgtgaga aaaagaccat tcctaccccg taacgttctt tttctggcag 2014381 attgatgttt ttgcactctt ttctaaagaa agcatcaggg atttgaacca gtaagccggc 2014441 tccgtctcct gtatccggat cactgccttg ccctcctcta tggtctagct ggcaaagcat 2014501 cttaagtcct tgtttgacaa tgtcgtgagt ctgcttgccc tttaagtgtg catataggcc 2014561 gattccgcat gcatcatgtt caaattcagg acggtagaga ccttgagctt ttggcatttg 2014621 attgtacgtc ataattcctc tcccccgatc aatttccgat aataccggtc ataaaatcta 2014681 acaactctat aatcattgta ggttttcaaa acgatataaa caatatataa tttagatcaa 2014741 aagaatctca aaatgagata gatggatgtg agacaaacat ggagctgcgc caactgcgtt 2014801 attttatgga ggtggctgaa agagaacacg tttcagaagc cgctgatcat ttgcatgtgg 2014861 cccaatcagc aatcagcaga caaattgcca atcttgaaga agaattaaat gtgaccttat 2014921 ttgagcgtga agggagaaat atcaaactca cgccaatcgg aaaagaattt ttaattcatg 2014981 tgaaaacggc gatgaaagcc attgattatg cgaaagagca aattgatgag tatcttgacc 2015041 cgcatcgcgg aacggtaaag atcggctttc ctacaagcct cgccagccag cttttgccga 2015101 ctgtcatttc agcgtttaaa gaagaatatc cgcacgtcga atttttgctg cgccaaggct 2015161 cctataagtt tctgattgaa gctgtcagaa accgcgatat tgatctggcc ttattagggc 2015221 cggtgccgac gaatttctct gacataacgg gaaaaatatt atttactgaa aaaatttacg 2015281 cgcttgttcc attaaatcat ccgcttgcta aacaaaaaac ggttcattta atcgatttgc 2015341 gcaacgacca atttgtattg ttcccggaag gatttgtact tagagagatg gcaatcgata 2015401 cttgcaaaca agcaggcttt gctcctctcg tttccacgga gggtgaggat ttggatgcga 2015461 tcaaagggtt agtgtccgca ggaatgggcg ttacccttct gcctgaaagt acttttgctg 2015521 aaacaacacc tcgttttact gtgaaaattc caattgagtt ccctcaagta aaacggactg 2015581 tcggaatcat taaaccgaaa aatagagagc ttgcgccttc cgcgaatgat ttttatgagt 2015641 ttgtcattca atttttctct aagctggagc agtatcaata aaaaaaatga acccgagctt 2015701 ctatatagaa gcttcgggtt tttttctgca aattaattta caggtaaaga aaaatccaca 2015761 tggcaaacaa atgcttcttg atcaattaga gctctatttg tcagttcctt tttcttttcc 2015821 ggttcttgaa gctgtacaga agagtaattg acgattccaa ggccgatttc cgtccctttt 2015881 gaatccatca gccgaacaac tgaaccgctt ttgaatttcc ctttaatctt ctgtacaccg 2015941 tctaggtata aactcgattg tccgtttgtt atttttcgtg aacaatcatc tgataaaatc 2016001 atttcacctt ccggaccgga attaaaagcg atccattgct ccttttgatt caacggaagc 2016061 gttccttctg cttcaaaata ggtgccttcc gcctgttcat gaacggcgtg gtataaaata 2016121 tcgccagcat ctgcctgacc taggaaacct ttaatgccag acgccattac gattttaaac 2016181 gcatcaagct tagagcgcat gccgccggtg ccaacgatgc ttccagtgtc acctgcgcat 2016241 gcttcgatgt caggtgttat ttcactcacc cgctgtatct ttttcgcttc tggatttgtg 2016301 cgcggattgc cgtcatataa tccgtctata tctgataaaa tcacaagcat atctgcatca 2016361 atcaatcctg cgacttttgc tgcgagcgta tcattgtcgc caaacttgag ccgattgacg 2016421 gtaactgtgt cattttcgtt tatgatcggg atgatgccgc gctcgagcag tacattcatt 2016481 gtattcctga cattgttgta tcgatattca tcagaaaaat cgcttctcgt aattaaaatt 2016541 tgggatgcga catagccgtg tgccaaaaac agctttgaat aagcctccat tagcaatccc 2016601 tggccgattg aagctgatgc ttgtttttct ggaagcttct cgggcctttg gataaatccg 2016661 agcttccgat atcccgccgc cactgcgcct gaggaaacca aaatcacttc ataaccggcg 2016721 tctttgagtt tgacgacctg gtcgaccaac gcttctaatt ttcgaatgct gatttctcca 2016781 tgaaggcttg ttaatgaact gcttccaatc ttcacaacga ctcttttcat gcttgtatca 2016841 ggcgtcactt tatcactcct gatagcggcg ctgcagtttt ttcgatatct tcgctgattt 2016901 cctttgaacg cttagccgca tgctttattg cttgagaaat cgcttctccg ccgccgctct 2016961 ttttcaaggc ttgcagcccc gctgctgtcg ttccgttcgg tgacgtgata ttatctctta 2017021 agatctcagg atgttctcct gtttccatga gcatttttgc ggcacctaaa agtgtctgtg 2017081 cgccgatgct tcgagataac tgtttatcga ggcccgcttc ctcgcctgtc ttttcaatga 2017141 attccattaa ataataaaaa tacgcgggtc cgctgcctgc aattccggtg aatatatcca 2017201 tttgattttc ttggattgta tagacttcgc ccatgcatcc gagcaatgct tcggccagct 2017261 tcttcaggtc ttccgacaca tatttgccaa gggcaatagc tgttgcagaa gcgccaatca 2017321 tactggaagt gttgggcatc actctgacaa ccggctgttc attaagcaat gattgttcaa 2017381 taaaagaggt agttatgccg gcaaggaccg acaatattaa ttgatggggt tgaatacgtg 2017441 attttagtga tgacagagcg ttttcggcgt cttttggctt cattgccaaa atgagcacat 2017501 ccatgtcttc aatacatagt tggttcggca aggcgccttt aatgccatat tgaagttcaa 2017561 gttcagttaa tcgctctgta ttgctgcggt ttgtaacgca gatgttttgt ttcgggattt 2017621 tgttggctcg aacgatacct gatatcattc cttccgccat agatcctgct cctataaagg 2017681 ctactttctt ttgatcaaag atcggtaaca tctcctttgt tcgctttttt gttcgcattt 2017741 tcacacgttt aaaatgttac cacgtgagga aatgatgtca agtttgaagg ccattattga 2017801 tttgtattgt ttcttttcga caaatatgta taatgaaaag cagaaaacac ccggttcaca 2017861 ctgctgcgcc gggtgtttgt ttctattaaa aattatctga gagagctttt tcaatcagtt 2017921 ttttacagcg atccagctct accttcagct gttttttata tagcttggca gcttcgtaat 2017981 ctttaaattg atagaggacg acttcctgga gcttagcccc ttcttttttt actttaattt 2018041 gttttagtat cccgtcatca agaagctcat gcaaagaccg gtatacttct gtatgatttg 2018101 gtttaaaacc aatctcttta aattcagacc gaagtacttc aagcagcttt aacccataga 2018161 gtctctcttg ctctgtcatc gttatcatat aaagcttcaa aaatgcgcgc tgtttcacta 2018221 aaaagcctgt tgaactcctt ttttcttctt tcatcatatg cactccttct tctgtcactg 2018281 acaacactat gtactaaata ttcaattttc ttttattgtt ttccttcttt atattaaaga 2018341 ctgatagtcc agttatttca tgtttactga ttataggtgt agcggaaaaa ataaatttcg 2018401 actgaacatt tggtacatag ttttcttagt tctattatag cctgcattta ctgctatctt 2018461 caatttaaac gattgccagg gtttacatat ctcattttac cggtacggat ttcattcaaa 2018521 taaaaaaacc tgtcgaaaga caggttttca tttttaagga tttgttgacc ataatcccgc 2018581 tgttttgatg aaaatacgag gatctaattt cagttgtgcc accatgtact cagcaagatc 2018641 ctcaggctgc ataacttttt caggattacc gtctgttaag ttcaattcga tagacatatc 2018701 actagcgaca gtgctcggcg ttaacgcgct gactctgata ttatgttttc tcacttcttg 2018761 cataagagac tctgttaacc cgagaacggc aaatttagaa gcgctgtaag cacttgttac 2018821 agcagctcct ctttggcccg ctgtagatga aatattaatg atgtctccgg ctttgcgttc 2018881 gatcatttcc ggaagcaccg cgcgagtgac atggtacaca cccattaggt tgacttgaat 2018941 aatattttcc cactcatcag ctgacagatc taagaaaccg ccaaatttgc tgatgccggc 2019001 attattaatg aggatatcga tatcaccgag ctgttccttc acttgagcta cagcttggtt 2019061 aacctgatcg gcatctttta catctgcagc agcaaatgca gcttttacac caagcgcttt 2019121 gacttcttca gccacttttt ctacattagc ggaagtccgg ccaattaacc cgatattcac 2019181 gccttctttg gcaagcgcca gagcagtagc gcggccaatt cctctgcctc cgcctgtgat 2019241 tagtgcagtt ttatgttgta aactttgcaa ttgaagcacc ctttctttgt ttacatatgt 2019301 acgatatcac attataagta caatacatcc aatacgcaaa tcaaacgaac tgtgtaaata 2019361 tcatttcttc tgattaaaaa aacggataca gggtaatgac ataagaaaag gagtgaacat 2019421 atgattatag tttatatcag tcttgcagta ttagcagttt ctattatctt cttaggagtt 2019481 accgtgatcc aaaacaagaa aaaaatagac cccgcactaa aggagctttc ctctgttacg 2019541 caggctatgc aaaaacaaat cgaaggatta aaaacagaaa cagagctgct gacgcaaaaa 2019601 caaaagaaga ttcagcagga tgtccaaata aaaaaataca cgcttcagca gaccgcagct 2019661 gaagtgaaag aagttcccca agcagtcaaa gaggtgtggc aggcaggaca ttttaatagc 2019721 agataaggat gaatgagatc ccgttgttac gatcagaatg gacaaatggg atctcatttt 2019781 tcgaggaggc ttacacatga ttataaaccg cagctgctta aaagagttcg cagaaaaagt 2019841 acattttctt ccctcttcac ttacaaagtc cgatttactt actgatccat ttcgtctcca 2019901 tcaagaaaac gaacttggca tctactattc acctcataat gaatttatca atcgggatgc 2019961 ctcgcttgtg attgccggga tcacgcctgg tttttcccag atgaagacag cgtacgaaac 2020021 agccgccgaa agcctgctgc aaggcgggac tcttgagcaa atggcagtag acacaaaaat 2020081 agcagcgggt ttctccggat cgatgagaca taaccttatt accatgctgg atttatgcgg 2020141 gctgccgcaa gcttttggca ttcaaagcgc cgcaaagctt tttggagaat tacggcatat 2020201 gctccataca acttccgtta ttaaatatcc tgtctttatc cagcaaaaaa actataccgg 2020261 atacaaaccg gctatcactc attctcctat cctaagcact tatgcttttg ggcacttccc 2020321 tgcagagctt aaccatgtga cgggaccagc tcttctcatt ccgttaggaa aagcggccga 2020381 aacagtgtgt gaaacattga tcagacagca cagcctccag aatttgattt gccttaacgg 2020441 ctttccccat ccatcaggcg cgaacggcca tcgtttgaaa caattcagca aaaacaaaga 2020501 gcaactagaa agacaaattc gttcctttgc tgcattggtt gatttcgcta tagaaaagag 2020561 gaaataaaag ggatatgata aacaaaaaca caaacgtggg gagtggttga atgtttccta 2020621 tattagaaac ggatcggctt atacttaggc aaatcacaga tcaggatgcg gaagccattt 2020681 ttgcttgttt ctcaaacgat gaggtgacac gctattatgg gcttgaaaac atggaatcta 2020741 tagaacaggc catttcaatg attcaaacgt ttgctgccct ctatcaagaa aaacgcggta 2020801 tacggtgggg aattgaaaga cgggacacta aagaactgat cggaacaatt ggctttcacg 2020861 ctctggccca aaagcatagg cgcgcggaaa tcggttatga aatcatcccg gagcattggc 2020921 gaaacggatt tgcatcagaa gtcatttcaa aggtcgtatc ttacggattt tctgcccttg 2020981 gactgtcgcg tattggcgca gttgtattta ccgataatga agcatcaaat cgtctgcttc 2021041 taaaaatggg gtttcaaaaa gaaggcgttt taagacagta catgtatcaa aatgggactc 2021101 catatgatac aaatgtgtac tctattgtga aaccaagaga atgacggtat tctcttggtc 2021161 tgtgccacat cccttttcct ttaaaaagat aaaaagcgcc cctcaaacag ggcgctttct 2021221 aattaagatg catattgagg agatgtttcc tccttaactg ctttttcctc aggtatatga 2021281 atacattttg tcaagaccgc acttgcaagg taaagggccg caaagatcca gacgacacct 2021341 tgcgcgccga cgagaccgat gaacagccaa gcgagtgcag ggccgacaaa cgctgataaa 2021401 cctgcagcta aattcaatac agacatggct gcccctttat cttttcctgc caccgtcggc 2021461 acaattgcac caatcggcac atagcctgcc agcaaaccgc cccaaataaa gccgatcacg 2021521 ctgacaaccg ctaaacttcc gccggagaaa acaggtgcgt agtataataa gacggtgaaa 2021581 atgccgcagc cgactccgcc gaaccaaata acagtatttt tccagccgaa tttatcgccg 2021641 acaataccga agataaggtt aaacacaatg ttccccagga aaatcgttcc ccaaatttgc 2021701 agccacacat tggttgaaat tccatgctgg gccatgtgca tcggcaaaaa gactggaaaa 2021761 ccatatgtac caatgctgtt gatgattctg atgattccgc ctgtaagcac gcgcggattt 2021821 gtaaatagaa tcgtaacccc ttttaaaagc tcctcggctg tttctgatct ttttcttttc 2021881 ttcttttcaa aacggtcttt attgataaac aatgcaaaga atgcaccgag acatacccag 2021941 aaaatagagc tccaaagcgt attcaaataa ccgaacgctt tgatcgcgta gcttgagtac 2022001 caagcgccga acacaaacat gccgaggcaa tatgcaatcc aaaaccagcc gacagcagtg 2022061 ctcagtttgc tttgcggtgt tctgtaaatg acccatgtca agaaagaata agcaaaaagc 2022121 gggtaaccta acccttttac gaagtaagtc acatacatca ctggcaggtt cagctgttca 2022181 aatccaaata cgataaaagc agctgtaccg atcacataaa acaacagccc cataaacatc 2022241 gttcgttttg cgccaaatgc ttcgagacat acacccgaaa accaggaagc tatggcaagc 2022301 gcaattccgt atatactaaa aatggaagcg gactgctgaa cggtgagccc gttttcgatc 2022361 aaaaaaggac tgagccagcc ttgttcaagg ccatctccca tcataaacaa aacaacccct 2022421 aaaaatcccc aggcaagccg cttcggtatt cctattttat ccaacatatc tgtctcctcc 2022481 ttagatgcta ttattcatta ccgtattacc ttattaaagt tgaaaattaa atgattcctc 2022541 aaaacagcag aaattccgtc ttaaattaat actttgcttt ctgatcctga aaaaaagcgc 2022601 tgtgtttgct tccattcctc atataaagcc aattctatct gacagtcctt cggttcgatc 2022661 acccggacat ttgctgacat ctcctccgtt aattgaaagg tttcattgca aatgactgca 2022721 gcaccgacga cagatgcctg atgatatccc tcttggacat agaccttttt ttgaagaaga 2022781 tccgcgatat attgagtgag cgctttgctt tggaatcccc ctccgcacac ccaaacataa 2022841 tcacgttcaa acggagtaac ctctgttaaa atgtcaaagt tccatttgat tgaaaatgcg 2022901 atctcttcta gcgctgcacg tacaaaatgt gccctcttta aatgtgctga cagcggggca 2022961 tcaaaaagaa aaccgcctct cgttaacgca ttcttttcag ccgataaata agagccgaga 2023021 gccgctacac atgcatggtc ttcttttgca agtgcagaaa tctcctcctc cattacttcg 2023081 tacgtttcat tcggataaaa aatctgtttt aatttttgat aattcaagcc ggtaattccc 2023141 ggattcgttt ccacaagcca atgcccttga tccgtatgac agttcaacca ggctttatgt 2023201 tttgtgtcgc catgatcctc agtaattttg gttattggcg ttgttgtccc tgatacaatg 2023261 acaatgtcct caagtccagc tccggtgctt ttgacagcca gctgtgtatc cccgccccct 2023321 gctataacct tagcatttat tgaaaggcct aattcggatg catattcatt tgctatcgtt 2023381 ccaattgctg ttcccgctct tacaagaggc ggaaggatag atggagaaaa gccgaaaatg 2023441 tcgcacatct cttctgacca agtgttttgc ttcacatcaa atagcagggt ttctgttgcc 2023501 tgtgatggtt catatgttaa tattccgctc agttggtacg tcacccaatc actgatgctt 2023561 gtaaagcttg cagtcttttc ccataaagag ggctggcgct gttttaatcc ataaagcttg 2023621 agcgcagaaa aaagtgcagt tggcaggcgg cctgtgctgc tgtatatctc ttcccaatcg 2023681 ggaatgcccg cctcccactc tcggccgcga ttatcgatgt tcggcagccc gagaaaagga 2023741 ttgccgtttt gatcaatcaa aacaatcccc tgtctttggc tcgtcgatgt caaaccaatg 2023801 atgtcaatat cacacgaacg ggatagcgca cgttttgcca aattcatcac ctgcttccac 2023861 agcacctgag gagaaaaata acggctgtcc gggtaaagcg tctctgtgga atactcgatg 2023921 tcctcccgtt caactgttag aacactgcca gttacactca cgaccgctac cctcgcattg 2023981 cctgtgccaa tatcaaaaac gagatagcct ttttgttttt tcattctgtt agcctccttt 2024041 cttatccccc tgttttcagt gcgtccttgt tatacattgt ctgaatatta agagtttttt 2024101 cacccttcca ctttttgagg gctttattca gtatcgtcac gtgatgatcc tccacttcaa 2024161 atgttgctcc agcgagatgc ggtgttgcca gaacattagg caatgaaatc aattcataat 2024221 ctgattcctc tggaggttca tgataaaaaa cgtctagtat cgcaccgctg attttatgtt 2024281 cttttaatac aaataaaaga tcttcacggt ttacaacaac tgctcttgaa gtattaacga 2024341 aaatcgcact ctctttcatc agatcaaaat attgccgatc tatcagtccg agtgtttcct 2024401 cagtgcgagg cagatggaca gaaacgatat cgctgtctga aaacaccgtt ttaagagatg 2024461 ctttttcata caacggatga tcgtcttgaa tgtatggatc gtaatatttt atcttacagt 2024521 caaacgcagt cagcagtttt gcaatccttt gcccgactgc gccgaaccca atcatgccaa 2024581 ccgtttttcc tgttagctca tttcctttaa atttgacata agcctgcagg taatcactgt 2024641 cccactctcc atccttcagc cactgattcg aggcgctggt atggcgcaga aaggaaatca 2024701 catttccaat aaacatttcg gcaacggctt gtgcattccg ccctggtgta taaaaaacag 2024761 gtatgcccct ttttgaggca gctgccacat ccacatttga gggcattccc ctgcaaacac 2024821 cgacaaatga aagttcggga acagaagcaa atacgctgtc tgttacctga tcaagttcag 2024881 taatcaagcc tgtcgcattt gttgctttta gcagctgaat gagttcatcc tcccgatatg 2024941 ccctaccttg ttccttccaa gattgataag caactgagcc aaacaagttt tcaagctctt 2025001 ttcgtccttc ttcgttgtac ggtgctgtaa ccaaaaccgt catgctgcaa aacatccttt 2025061 tcatcgtatt tttcataaaa aaaatctctt tccgaagatg gaaagagatt catatatagg 2025121 cgcgctctgt tacaggcaga cgccggtata aaccttgctt tcctatcttt caagctagcg 2025181 cttgctggaa ttggcacaat aatgttgccg aggtttcata gggccagtcc ctccacctct 2025241 ctggatagaa aatattgagt atgtaatttt cagaatgaag aatacgttta tcataaagaa 2025301 gactcagatt gatgtcaatc tctttttttc agaattgacg ttatcatcgg aaatgttata 2025361 attcttacaa aatatctaac tagagagagg aactgggcca tgagatcttt tgccacacaa 2025421 caaaacggca ttttcaaatc cgtttgctcg ctggactgcc cggatcagtg cggattgtta 2025481 atacataaaa aagacgggaa aatcgtaaaa gtgcaaggag accctgatca tcctgtcaca 2025541 gctggaaaca tatgcaacaa agtccggaat atgacggagc gcatctatga tgaaaagcgg 2025601 ctgactacac cgctcaaacg aacaggtgcg aaaggccaag cgatatttga accgatttcc 2025661 tggaaagagg caatcgatac gatcacctcc cgctggaaac agctgattga tgaagaggga 2025721 gctgaaagca tacttcctta cagcttttac ggaaatatgg ggaaattgac agctgaagga 2025781 atggaccgcc gcttttttta ccgcatgggg tcaagccagc ttgaacggac gatttgcagc 2025841 aaagcgggat ctgaaggcta taaatataca atgggcataa gcgcgggaat cgatcctgag 2025901 gaaaccgttc atacaaaact atttattttt tggggaatca acgcggtcag cacaaatatg 2025961 caccaaatta cgatcgccca aaaagcgcga aaaaaaggtg ccaaaattgt cgtgatcgat 2026021 gtgcataaaa atcaaacagg acgtcttgca gattggttta tcccaataaa accgggaacc 2026081 gacagtgcac ttgctcttgg catcatgcac attttattta aagaaaacct tcatgatgaa 2026141 gcatttctgt ccgagtacac ggttggctat gaagagctcc gtgaacacgt gaaacaatat 2026201 gatcctgaaa aggtatcgac gatcaccggt gtcagtaccg aagatattta ccgactggca 2026261 aaaatgtacg gggaaacctc cccttctttt atcagaatcg gaaacggacc ccagcatcac 2026321 gataacgggg ggatgattgt aaggacgatt gcctgtcttc cggcgatcac cggccaatgg 2026381 ctgcacacag ggggcggcgc aattaagcat aacagcggaa ttttagaata taacacaaat 2026441 gccttgcagc ggcccgactt attgaaaggg cgcaccccga ggtcgtttaa tatgaatcag 2026501 cttggcaggg tgcttttgga aacagacccg ccgattcgct ctctatttat ttacggaacg 2026561 aaccctgccg tcgtcgcgcc cgaagcaaac aaagtcagac agggcttgct gcgggaagac 2026621 ttgtttactg tggttcatga tttgttttta acggaaacgg ctgcatatgc ggacattgta 2026681 ctgcctgcaa catccgcttt tgaaaatact gatttttaca cctcctactg gcaccattac 2026741 attcagcttc agcagccggt gattgagaga tatggggaaa gcaagtctaa cactgaggtt 2026801 ttccgattac tggctgaagc catgggattc acagaccagg agcttaaaga ttcagatgaa 2026861 gtattaatcc gccaggcgct tgaccatcca gataatccgc atttggcaga gattgattac 2026921 gattcactta ctaagcattc atttatgaaa gcgaaacgtg aaaagccgct gtttccgggc 2026981 gaacttccaa cgccaagcgg aaaaatagaa ttatattcag aaaaaatgaa acaagacggc 2027041 ttccctgctt taccgacata tacacctctt gtaaccgata atgaacatcc gtttatgtat 2027101 gttccggggc caaaccataa tttcttaaac tcaacatttt ccaataatga aaaacacatc 2027161 aagcttgaaa agacgccaaa gctctttatc aacacaaaag atgctgaaaa acacggaatc 2027221 gttgatgggg cacctgtacg aatttggaac agccggggag aatgcgagct gaccgctgca 2027281 gttggagaac aagtgctgcc aggtgtcgtt gtcagccaag gattatgggc ggatgaacaa 2027341 ggaaaaaaac agcttgtaaa cgcgctaacc ccagatcgct tgtccgatat gggcggcggc 2027401 gccacctttt tttcaggccg tgtacagatt gaaaaggttt gaaaaataat gaaacccgga 2027461 gtatgccaag cccgtataac ataacatcga cataatggag gcatacacat ggacgttttt 2027521 ttaggaattg gtattgcttt ggctggatat tttatcggtg aaggcttaaa gcagaggaac 2027581 caaaccaaag gtaatgaaca aaatgatatc ttcctaataa aagaacggga tatttacttt 2027641 tacattggac tttttttagg aataacaacg actgaagcaa aacagttagc tggagacatg 2027701 gcagacctgc cttacatcga aataaacgga aaaaaatatg tccagaaaca tatgttaaaa 2027761 gattggacat tcacattagt tgaaaaacat cagggtgaat aaaacaaatc tgaggagagc 2027821 gagattcatt gtcacgctct cctctgttta gctgtatgga tcctgccacc aaaactttgt 2027881 gctataagcg ctgataaaac gataaaccac catctatgtt ctttcctcaa acaactcaag 2027941 atgcccgttc cacaacaata gtttttatat tcctttgatg acgtgatgtt cttgatgaac 2028001 gtatgtatcg taaaacactt agaaaaccta ttcggtttga atgtgtgctc tcattatgcc 2028061 cccatactgc gcctttatcc gcggaggatt tttttaaaaa aatatgaaac ctaaagcttt 2028121 tagatcctga atttttattg aacctccata tttctccgat tggtaaaaat tagcctatac 2028181 accggaagct gtacgtttat aaaggatcag agaatcccat aaccagtaaa tcactgcagc 2028241 cgcaatactt aacatataat aaaagtacga ttgcaatgtc catgctattg acgcaggttc 2028301 attgataaca aaaaacagga aagctgcgat aaaagcaacc acactgtaaa tcaataggta 2028361 catgacattg aaagttctcg cttttttctg caacttcatt tggagcggaa cagcaaaaag 2028421 gccatacacc acaaaaccgt ataataaagc aattgctgcc gtaaacaatg caattatcat 2028481 atcgccatac ataacgaaag aataaaaccc taataacaaa ccaaatgtaa ggctggatag 2028541 ccctaatgtc attaaataat atgatgcgat ttttttcatt ttttcacccc ccttgtttga 2028601 tttattcaca gtgctgttag tataaattca caacctttgt atttctttta tcgagatgtc 2028661 ttccctaacg tgctatacgc aatgcgctaa taaaaggttt caaaaatgac gttcttttat 2028721 tagataatac gctggctgaa aacgcctctc ctgattggcc aaagcgcgaa tgaaaaaagt 2028781 gcatgaatac ctgcccaaca gacagaataa gaagagttga tatttcaaca cttttcgtaa 2028841 aggggtgaaa ccaatgagta agaaaggtat tcaaaattca agtattgaac aaataagaaa 2028901 tgaccatgag actgaaacag cttttaaagc agatgatcct aaaaaacacg gttccgatcc 2028961 taaaagaacg aaataagttc ttacccccac taaaatatca ataatctgga ggaagtaaag 2029021 tgactcaaaa aaacggtgca gacagacctg atgattataa aagattttct tcattagaca 2029081 aggaatatga ttttcagcaa tctatacgca gcaatactga gacagaaagt gtaaacactg 2029141 aaacacaaac tcataacaaa gaaaacaaaa atgacacaac agatgttgcc gggaaatact 2029201 ttgagccctc agattataaa ggaagcacgc aattagaaaa aggattggct gaaactcatg 2029261 aacaggtcag cgatgactat tttgaaggga caatcgatca aaatttggac tagccataca 2029321 aacggaacta acttaaaaga agtcagttaa ctctgttttt agaaacaacc acagtaaaag 2029381 tagccaaccc ccaccgaata agatgggggt tgcacgtaag tagcctgttt aatatttaaa 2029441 acgattaatg acggtttgaa gttcttctgc caactgagat agagattctg cggcatagga 2029501 gatttccccc attgaatgaa gctgttcctg tgatgaattt gcaaccgctt ctgtatttgc 2029561 tgacgtttct tttgtaccag cagccaatgt atgaactgtg tgctgaatca cttcaacgcc 2029621 tgaagtaagc tgttgagttg ctgctgcaac ttcttgtatt tgagaagtga cctgttccac 2029681 caggttcagt atttcattga aatttcctgt tgtctcttga gaaagaacaa tacctgagct 2029741 cacattttct tgaacaactt taatattatt taccgtttct atcgattcgt tttggatggt 2029801 cgctaccacc gattggatgt ggtttgcaga tttatttgtt tcatccgcca acttccgaac 2029861 ttcttctgcc accacagcaa atccttttcc ttgctctccg gctctggccg cctcgatcgc 2029921 tgcatttagt gccaacaaat ttgtctgctc tgaaatcgtc gtgataagcg aagagatatc 2029981 gctgatttct gctgtgctcg ctaccaatgt ttgcaatcca ttgccggctg aatctacaga 2030041 tttatcaatg aatttcatct ggtctaacat cttgttgacg gacttagagc ctatttcagc 2030101 cttgtctctc atcgaagaag aaagatccgc tatgttccct gtatttgaag cgactgatga 2030161 tatactgtct aataattcag tgatggattc tgcgctcttt tctgtcattg agctttgctt 2030221 cacattgctg tcggcagcca tctgcatggc tcgtgaaata tgttcagatg ttgatttcga 2030281 ttcttccgcg cttgccgata attcttcaga ggaagcggcg acttgttcag atgagctgct 2030341 gatctgcttc acaatttgag ttaatgaatg agtaaaagaa ttaaaagatt gggcaagctg 2030401 gccaaattca tctttatttt tcacaatgac ttttttggtt aaatcagcct cgccgtgtgc 2030461 aatttcctcc agctgcttat ttatgcttct tagtggcacc ataatggact ttaacagcat 2030521 tatgcttaga acaatgccta atattactga tatccctgtg acaatgataa tgagcgattg 2030581 actcattttc ccattgccct gtatttcatc ctttagatcc tctacctctt gatccaggcg 2030641 atcagacagc ttattgacag ccggagctac gccttctttt cttattgttc tttcttctcc 2030701 aaaatggatg gtttctgctt ttttaggatt tgaagagtag gctgttacta cttgctgatt 2030761 caaagctcta tactgagtaa aacttgtctt aatgtcttca atattggatt gatacttctc 2030821 ttcatcaatc aagtcattaa cccggtcaag gctctttaag acatcgtctg cttttccctt 2030881 cataccctcg tcgtattctt tgtctctggt aatcaagaag cctctttcat catttgataa 2030941 cccggtcaat tcatattgga tgtgttttat ctctttttgg aattccattt tgtctttaag 2031001 ttcttcattc tttttcacag tagaagaaat cataaatact gaggagcctc caattccaat 2031061 aattgaaaca actaatattg atataatccc cagcaatttt gttttcactt tcatgtgtcg 2031121 ttttcccttt ccgcacaatg taatggctga aataaaatat gttcaagcgc gtttgaatcc 2031181 aattcgctta cgctcatgtc cataatatcg acacgtgtta tcaagtttta tagtgatatt 2031241 cttatatgaa taagcaaatt ctttacgtct ctgaacttac agaaaaacct taagtaaaat 2031301 ttgcagtctt ttgcggtatg taagtcactc ttattcgttt ttctaaaaaa ggcttttccc 2031361 acctcaaatt ggctgaaccg gctgttttct cgaaaatata atacaatacg cagcataata 2031421 tgaaggagcg aaacttaaat ggggatcatc aatggtaaag aattcattga ccgattgaat 2031481 aaactagaaa acgaaatatg gtatgatggc gaaaaaataa agggtaacat ttctgagcat 2031541 cctgcattta aaggaataat caaaacaaaa agctcacttt atgaattgca aacaaaggat 2031601 gagttaatac atgaaatgac ttattgcctt cctggagatc ataatcgaat cggcctttcc 2031661 tatctccagc ctaaaacaaa aaatgatttg aaaaaaagaa ggaccatgat tgaacattgg 2031721 gctagacata ctcatggaat gatggggaga agtccggatt acatgaatac ggttatgatg 2031781 agctttgctt cgtcagcgga gcttctaaaa gataaagaga attgctttcc tgaacatata 2031841 ctagatatgt atgaacaagc tgctaagcat gacctttcct ttacccatac attcattact 2031901 ccgcaagtga accggtcaca gtcctatttt gggctaagtg aaaaaccgat atctgctaaa 2031961 gtcattgata gaaccgaaaa aggtttaatg attcatggcg cacgactgct tgccacacaa 2032021 ggcgggttga ccgatgaaat cttggttttt tcagcgccta aatttttctt tgaaacagat 2032081 gaagcttatg ctttttcaat cccttctaat acaaaaggcg taaaattcat cacaagagaa 2032141 tcatttgtat taagcgactc ttcctttaat catcccttaa gctcaaggta tgaagaaatg 2032201 gattcaattg tggtttttga tcatgtgtta gtgccgtgga atcgtgtgtt tttttacgat 2032261 aatgtggaag cagctaaaga ttttatgaca aaaagctctt ttcatgcctt tacctttcac 2032321 caggttgtca ttaggcaaat gataaaaatt gaatttctat taggtgttgc acagcttctt 2032381 gtcgacacca ttaatgtttc cgaatatcag cacatccaag aaaagctctc agaaatcatt 2032441 gtgggattgg aaacaatcaa agccctcatt gacaaatcgg aaaatgatgc tcagttagat 2032501 gaattcggct atatgcgccc ctgtttaatt cctcttcaag tcatcagtac gatcattcct 2032561 aagctatatc ctcgatttac tgaaatcata caattaattg gagctagcgg aatggtgaca 2032621 ctgcctaccg aaaatgcatt tgactcagag atacgggaag atcttgacca atatcttcaa 2032681 gcaaccaata caaatgctga agaacgtgtg aaaattttcc gtttggcatg ggatttaaca 2032741 atgagttcat tcggaactag acaaactcac tacgaaagat attttttcgg agatcctatt 2032801 cggatttcaa gcaggctgta taccagttat ccaaagcagg agcagttgaa catgattaaa 2032861 acatttttac atgcagatac agaacattga aaaaacagcg ggaaaagatc cgctgtttcg 2032921 tattttttat tcaggaaact gaacatggcc cggtactgta taggctttgg acgttccgct 2032981 ttcaggcagc tttggaatgg tgtctttcac aacttttccg cggatgtcag tcattctgac 2033041 tttgagagag ccagtaccta aattcgtact cacaaaatgg ttatagtcca ttttctccat 2033101 gttgatccac ttaccatcct tttcatattc cattttcata acaggatact tgtgatttct 2033161 gacttggatt gctgcccacc acctgctgct gccttctttg atccggtacg tgaaattgcc 2033221 ggtgattggg gctttgacaa cacgccattt aatattgatt tttccgtctt tcatattgcc 2033281 gattttacgg aaggcattag gtgacagatc aagagctccc cgagcgcctt cgggataaag 2033341 atcagtaaca tatacggttg ttttcccttt tggcccttca acttccaaat aagagccggc 2033401 aagtgccgct tttactcctc cgtaattgag atccgccgga tttattgcag taatctccat 2033461 atcggaagga atgggatcca gcaggaaagc tcctcctgaa tagcctgacc ctgtatacgt 2033521 tgcataacct tcatgcaggt cgtcatatgc tgccgaagct tgcggggaaa aacagaagat 2033581 cgtcaacaaa accataccaa caaatgcact catgatcttt ttcatatttg gtcctcctca 2033641 aaccagactt caaatgagaa tcattatcat tataagactc aatccatctg gtttgaaaga 2033701 ggaaatagat tcatagttga ttttaaggca aattcactat cattcatata tcaaatgtag 2033761 gtacttatga aaaagccaat acaaatgaac gaatgtgcac ttcagccgaa tgtcttattt 2033821 ttccctctca aaattcgcat ttcaataacg aaatgaaaca ggctgttggc ctgataacag 2033881 ctatacagga aaagctattt ttccccgctc agtttcaact tagctgtcat catgatgcca 2033941 aagatcagca caatcggaac ccaaataatg aagtgataaa aatcaggctc agccagagca 2034001 acaataatag cccctacaca atacaaaata atagccagtg ctcttaacac agtatctctt 2034061 aagaaagtct tcttttgctt cttaaaaaac aaacggccgg atatatcctc taaaagagaa 2034121 gccaaagtgc cggtcaacac agttgaagaa atacctgcaa tccccagttt ttttgctgct 2034181 gtagtttgaa tccccataga aatgctcatg agtataatta gaatgtgcac aggaacaaat 2034241 gcccggtaaa aagaaagaca agcaaagaca aacaaaatga atgcttcaag tgcgagggct 2034301 tttgtcacag cagaaggcca aagggtattt tccgcctttc cgaccatcaa tgtagcaatg 2034361 atcacgccgc atataaatcc gattagcgca gtcaaggaat taaaaacagt gacctgaatg 2034421 gatttgccga tagctaaccc caataataca atgtttccag tcatattagc tgtgaacaca 2034481 tgtcccaggc ttaaataccc gattacatcc acgattccag ctgttaaaca taaaagtgat 2034541 agcaaggtgt ttcgataagc tgctgcagtc aacggtgtat caatcctttc ttctatttca 2034601 attgttagta tgtcttttgg cgcaatctct attttttaag taacccaaca ttaattagga 2034661 agatagaacc tattattcct ttccattaac tgtaataata atccccgcaa ggaaatgatt 2034721 aaaattgaaa ggaagcatat tgtgatgaaa cgactttgtt tatggttcac cgtctttagc 2034781 ttgtttttgg ttctcttgcc tggaaaagca ttaggtgcag tcgattttcc gaatacctca 2034841 acaaatggcc ttttaggttt tgccggaaat gccaaaaatg aaaaaggcat ctctaaaacg 2034901 ggcacaacgg gtggaaaaaa cgggcagatt gtttacattc aaagcgtaaa tgatttaaaa 2034961 acccatctag gaggatccac tccgaaaatt ttagtgcttc aaaatgatct ttccgcatct 2035021 gcgaaaacaa cagttaccat tggctcaaat aaaacactcg tgggctctta cgcgaaaaaa 2035081 acgctgaaaa atatttattt aacaacttca tcagcttttg gaaatgtcat ttttcaaaat 2035141 ttaacgtttg aacacagtcc gcagattaac ggaaataatg atatccagct ttatttagat 2035201 tccggtatga actattggat tgatcacgtc acattctcag gtcatagcta taatgcaagc 2035261 ggaagcgatt tggacaaact cgtgtatatc ggaaaatccg cagattatat cacgatcagc 2035321 aactcaaaat ttgcgaatca taaatacggt ttgattttag gatacccgga tgattctcag 2035381 catcaatatg acggctaccc ccacatgaca atcgccaata attattttga gaacttgtat 2035441 gttagaggcc caggtctgat gagatacggt tactttcatg ttaaaaacaa ttacagcaat 2035501 aattttaacc aggcgattac aattgctaca aaagcaaaaa tatattccga atataattac 2035561 tttgggaaag gcagtgaaaa aggcggcatc cttgacgaca agggcactgg ttatttcaaa 2035621 gacataggca gctatccatc actcaacaag caaacctctc cgctgacttc ttggaatcct 2035681 gggtcaaact atagctatcg tgtccaaacg ccggaatata caaaagaatt tgtcacgaaa 2035741 tatgccggat cacaaagtac aactctggta tttggctact gatataaaag aggccctgcg 2035801 ttaaaaacgc tgtgcctctt tttatactat aggctatttt taagcgatcc ttgtaattcc 2035861 atcaagatcc agcgtcggtc aaactaaaaa gcatatgttc ttttccacaa taacttctta 2035921 actggctttc ttattatacc agtttatcgc aagtgaaaag aaatcattgt tctgaacctg 2035981 tattaaatga acgatcgtcc cacaaactac ttaaaaaccc ctaaaaagga tgatggatat 2036041 gtgcggcagg tttactttgt actctgcatt tgatgatatt attgaccagt ttgacatcga 2036101 tcaatttttt cctaaaggtg aataccagcc aagctataat gtcgcaccat cacaaaacat 2036161 ccttgcaatc atcaatgatg gatcaaataa tcgcttaggc aagcttagat ggggacttat 2036221 tccaccttgg gcaaaagatg aaaagatcgg ttataaaatg atcaatgctc gagccgaaac 2036281 aattaccgag aaaccggcct ttcgaagacc gcttgtcagc aaacgctgca tcataccagc 2036341 agacagtttt tatgaatgga aacggcttga ttccaaaacc aaaatcccaa tgcggatcaa 2036401 attgaaatca tctgctcttt ttgcgtttgc tggcttatat gaaaagtgga gcacacatca 2036461 aggataccct ctttatacct gcaccatcat aacaactgag cctaatgagt tcatgaaaga 2036521 tatacacgac cgaatgccgg ttatattggc ccatgatcat gaaaaggagt ggcttaaccc 2036581 caaaaataca agccctgatt atctgcaaag tttgctgctg ccttatgatg ctgatgacat 2036641 ggaagcatac caggtttcat cattagtaaa ttcacccaaa aataattcag ctgagcttct 2036701 tgatgcagaa aatcatatgt agtgattgaa aaaattctct agcaagaact tgtcaaatag 2036761 ctttgttcct taggtgccaa tccctctagt aattatgaat atttagtaca tagatcaatt 2036821 agttatcttt agcatcagtt tgaaataatt ttattatgta aacttaaata agcaatgtta 2036881 ttcctttcat ataaaatagt ttacattttt ataaaatcgc ttcacttttc tattttgtca 2036941 gcaaaaaaac tgaaccacat taaacttatg aaacctgccg cacctgtgga ttgcaaatat 2037001 gatataagcc catagaggta aatccataca ctttccctcc taagaattaa atgaaatttc 2037061 tttcatctta catgaaggtc ttctttcttt tgtttatcca gtgtaatact taataatatg 2037121 ttgatgaatg cagctggaaa atatataaat cccactccaa gaatgcctag tatcgtactt 2037181 aaacttacta tgtaattctt tgtcatcgtt tgactgtcaa tcaatattag aagtgaaatc 2037241 aatccagcta aaacacctat aaaccaagca tcgccaacag cataagaatc atccagcatc 2037301 cctaaccatc gccccaatat agagctccca atggcagtca aactggataa aaatatgagt 2037361 gctttcattt cttctcctcc tttaaagcca atcaaactgg tagaaatcgg ccattgaatc 2037421 cccattatcg aatggttacc atttcatttc cacattaaca ttttaaagct cattacaata 2037481 cgattcaagc agaaaaaccc tacataacgt atatataggg atttaataaa acacaggcca 2037541 aaattcagct ctatctactt taaaaagata tgaagggcag ctgtgtgatc tgttacgtct 2037601 ttacgtaccg ggatatttca caacaggcac tttcttcttg cgcagagaat caagcatgac 2037661 tgatccagca ttcaagttgc tttgtactaa ttctttaggc gtcaatgcca tccactgatt 2037721 gagtgacaca tctgcatagc ggttactttt gaacatttct aaaaaccata atgtttctgt 2037781 accagtgttt tgtatatagt gtccggcatt agaaggcacg tatccaacgt cgcctgctct 2037841 ataatcaaat gtgcgggcag tcccatttcc gataaatacc gtcattcgtc cctgtcctgt 2037901 tagataatat tgccactcat cgctattggg atgccaatga agctctctca tcgcgccagg 2037961 ctcaatctga acaagtgcag cggctatcgt ttttgaaatt gggaagttag aagaatccac 2038021 aattcgtaca ctcccccctg gcatttgaat tgggggttga tttaacagct cgtgtttaaa 2038081 ggtcatgggg acttttccat atggtgactg aatgtcttca ctggcgactg atcccggcac 2038141 attcccttgg tagatataga cttgctcaga cggaagagag ttgaaagcat tctccgggac 2038201 accgaaattt gcagacagaa catcttttgg tgtgtgtgca agccaatctg aaatggttaa 2038261 cgttgaaaac tcagaaaagt tcccatcatc gaaaacgagc agaaactcgc agtgttccaa 2038321 tccctgtatg gaatgcggaa ttcctgccgg gaagtaccaa aggtcgccgg gaccaacatc 2038381 agcaatgaaa tttcgtccgt cttggtcaac agcggtgata cgtgcccgtc ccaaaagcat 2038441 ataagcccac tccgcttgct tatgccaatg aagctcgcgg acgcctcccg cagttaagct 2038501 catgtttaca cctgcaatcg cagtcgaaat cggaagctgt cttacggtga tttctcttga 2038561 ccagccgccg tgatctaatt tcatgggagc gtctgagaat gaaaatctca agttaggaat 2038621 cataccctca tctgtaacag gcggaacaaa tatattcgga ttttgaatat cccgtattat 2038681 atttcgcggg cctgtatcaa tagctccagc tccatcactt cgaataggct gcggcacgtt 2038741 tctgtcttca tgattgattg gttgttgttc caacagcatg cacctcgttt tagaaatgaa 2038801 caagatttta tttcagccta tgcagaatct tagattgctg tgcctaggaa tccgcaaata 2038861 aaaaagtgac caccaatgtg atcacaaata catcaaataa actatttttt ataccatggc 2038921 ttcttatgta atttgattgc ttctgtctgt tttttctggc ctgtcctcca ctccactttt 2038981 actaatacat catgacctat cacttcatct tcaggcatat aatcaaaggt ggaaatatgg 2039041 tcctccatgc gtcccccacc cggcatttca tcacctgtgt actccgataa gtcgtactca 2039101 tctacgttat catcttgata cttttcgcca tctacataca gagtaattct ttcaacaaca 2039161 gtccactttt cttccttctt actcccctgc caatatagat ttagaaaata attgggtcca 2039221 attgaagttt tgtctgattt ttcaaggtta gacatccaca gtccgctttt cccgctgccc 2039281 tcatatttca ctttgttccc tgacaccatt acaaataatg tgatgatgca gatgatcaag 2039341 aatccagcaa tgatcaatag ccatttctta atattgttct tttttctcat gtttttcctc 2039401 actttcctaa ctttttagta ggaaaatacg atcaaaatgt taccgaaaag aaaataagaa 2039461 agggctaatg atctaacaga tgactgtcta aacttttgac ttaaattaaa gtgctttcta 2039521 aagacaagat taaaacgtat aacagctctt aaatgcattt tttgtttcat tgagtcaaga 2039581 accttaaaat ggctttttat tattaaaaat caagctagtg tattaagtaa cttttcaaat 2039641 ttatttatac tcatgatctc gtgagtcaca aatctcccat caaaaaaaac gctaaaagtt 2039701 gtccaaatag ctggtgactt ttgtgcctct tctttcgatg ataactgaat tgactgaaat 2039761 tgaacccctt tcttttcagt caattcccgc aaatcattta tcatgcccac tgcaaacgga 2039821 cactgagctg tatagtatat cgtaatcccc ttttcattga tagaatcact tttcacctgg 2039881 ctcttaaatg caggagaatc tgcaaggcca ttccaagtca aagccattaa ttgaaaataa 2039941 ggggcagctt catcttgtag agtaaacccc atatgctcaa agaaatgctt atcacttaaa 2040001 tagggcagtt ttttcttgcc tgcgatatgg ataatgccat ccatgccgca cgctttcgca 2040061 tctgctatac atttgtccaa caatcgtttc gcatgaccgt tatttttata tctgccagac 2040121 acccacagac aattaatgta cataaaatta ggcgcattga taggcaccca tgcctcattc 2040181 gcaggtaggt attcaataaa gacttttgcc cgttcatgta agcgatagaa caccaatcct 2040241 tcatccattc gagctttgag ccatctcttc ttttcattaa ctgcatgctc atattgtttc 2040301 gtgcttaatg cacagcaaat atgattgtct tcaatattgt cctttgtgat ttcaatgtag 2040361 cacatctcct ctttcccccc tttaacataa ttacatggaa ttcaacttca cactttacat 2040421 gcctaataga ataaataccc gttccaactt aaatactttt tcttttccat tttgccaatt 2040481 aactgtaaaa cccttctttt attcagatat tatcttgatt cctatatcac ccatttcaaa 2040541 tccaaagtgt gttcatcttt gaggattaga tgcactgctt atgctataaa tacagtacac 2040601 gaagtttttt atttgaagta atatttgtta cgggacagca atagtaaata agtgataaaa 2040661 ggggaattaa acttggtgga aaaatgttat tcttgtttaa tttgcggata caaaggatta 2040721 attcaaaatc ctttgtataa aggcgagtat caaaaaacgt ttgacatttg tccatgttgc 2040781 ggttttgaat ttggctacag tgaggatcat gatgtgaggt taggttttat tgtaactcct 2040841 gatcatttaa ttgaggctgc atttcaattg tatcgcaaac aatggcttga gagcgggatg 2040901 gtaattgctc atccggaaga tattccagaa gaattgaaaa atggcaattg cttaaaattt 2040961 gaagttttgt tgaaacaatt gaaaaaacta aatcttgaca tagaaaattt tgaaattagc 2041021 ggtttttaat gatgaaacag gttgcacttg tttaggtttc actgtcatta tcagtaaaat 2041081 gttaagttga aatgcgcaat cagtcacaaa gtctctattc gtattcaata aagactttgt 2041141 gatcatcgac aaacatttca ctcccatcgg ataaagtatc caaaaggcct cctctggttc 2041201 ttctctatag tcattaatca cagtcacttt gacatttgac tcagctatga ttggttttcc 2041261 aacaattttt cgttttttcc tcaggcaaag taagagatcg aatcatcaaa gccattccat 2041321 ctttactgtc taattaacgc catcttcagt gaatttaaag gtctgtttta aattgcgtcc 2041381 ttcttgcccc ttctgtgtcc aaattataac aacctctaat tcagaggcct tatctgccag 2041441 cataaaatga ttgaacttca gcggtgagcc atcatttaaa ctttcagcta acattttaga 2041501 atcttctttt ggtttgacac aattttcatc gggacatcca aaaagcgaaa accttgtgat 2041561 tgaattaggg tcatttctat acaattgcac atccactgta gctgcttttt cccctatatt 2041621 tttgacttcc aaggaatata cttgatattc tcctttatga ggtctcgtaa attcctttac 2041681 attttttgct tcacttactt ttactgacca ctggtctgtt ttttgtgtaa taggcaacac 2041741 cgtaaaagtc agggcatgcg cttttgattg gcaaaacgta aatccaactg ctgtaaaaac 2041801 aattacagaa aataataccc ttttcacttc atttatccct ccttcctttc actggccgct 2041861 ccttaaagaa ttgattttga gcaatctaca agctctctta accaaaacct tacctgaggt 2041921 tttgtcttta ctgctctgca tttatttctt tcggtatccg agaaggagct ttggggattt 2041981 ttctcaatct gctgttaatc acatcagaag agtatagcgt aataatcata cttcccccat 2042041 acctttttgc ccgaattaag attggttggt tatattggtt ttgaaagcga aagtcaggac 2042101 ctccccagct taccgtcgca tcccgtccgg gcggtacata tggtacactt ctagtatgag 2042161 aatagcgctg aacgatctgc agtcctgcac gatctactgc attaaataga gttgaggaca 2042221 cctgacaaat tcctcctcct acaccttcag acaactcccc ttttacaata atgggtgcac 2042281 ttttatatcc tttgttccga gttctcattc ccacaacttg gttaaacgaa aacgtctcat 2042341 tagggaaaac aacgtgattg tcgattgctt ttgcagaaag agaaatattg tgtgaacggc 2042401 ttttattgct tgagttaaaa tacgtcacgt actgaccaag ctgctgcgta ctgatgtgag 2042461 ctagcagctc gctgtcaact ttcggataaa tgttcatttc cggcacttct atcttggagg 2042521 gaccttgccc ataaaaatac gcataaaact tttccataaa cgcctgttga tacagtttgt 2042581 agccaaccct gcccgggacg atgcttccat gatcgttaag gacagcattt atcggctcac 2042641 ggtacacttt ctgatcaagc tgtttgatga atttactgta tttttcatag tcaaccattg 2042701 gagtgccggg aagaggcatt gtaaagtctt cacggttaac agtggcaatc gtccgtcctt 2042761 gctgtgtgac cgttaaactg tcctgcggct cactcggctg agccaataaa aaaagaccag 2042821 tgatcaaaat ttgtatcata agtcggttta cctcccaatc attagtatga acagccgctt 2042881 atcctttgat gtatttcttc ccatcgtttg tttgaatctt tagacgttga taaaaacctt 2042941 cataaaagag cttagcttta tgttcacacc gatccctgag ctcactgagg cacacggttc 2043001 attcagtcgg caagtttgaa gtagttcagc atctcccagt gatgagggat gcttttttgt 2043061 cttgtcaaaa atgaaaaggg tctcctataa caacaaaaaa tcaatccatt tcaatatttt 2043121 tttattgaga aacgataaat tttttgttac attcaattag acaacaaata aatgaggtgc 2043181 ttgttatgaa tcgaatgtcg acaatttttt taaagatagc tttggttctt attggaattc 2043241 caattcttgc tttatgcatt tttttagtgc ctaaggtagc caactattca gcagaattat 2043301 ttccaaatat cgcttatata aaatatctcg ttttcatcta tttgtatgta acggcgatac 2043361 ctttttactt tgctctttat caagcgttca aacttttaag ctatattgac aaaaacaaag 2043421 ctttctcggg tttgtctgta agagctttga agaatataaa atattgcgca gtcactatca 2043481 gtatctttta cgcagcaggc atgcctgtct tttatctgat ggccgagata gacgacgccc 2043541 cgggtatcat tgtgatcgga ttggttatta tttttgcttc aatggtgatt gcggtctttg 2043601 ctgctgttct tcaaaaactg ttaaaagaag cgattgatat aaaatcagaa aatgacttaa 2043661 cggtctgagg tgatgacatg gcgattatta tcaacattga tgtgatgctt gctaagagga 2043721 aaatgagcgt aacagagctt tcagagagag ttggcatcac catggctaat ctttcgatat 2043781 taaaaaacgg aaaagcaaag gctattcgat tatcaacttt agaagcgatt tgcaaggctt 2043841 tagaatgtca gcccggggat atattggaat accgaagtga tgaagacaca ggattcgtaa 2043901 agaaaaaata tgaaggatca acagaaaaat aaagtgattg gcggtgagct tatggacata 2043961 aacttatatc catctagctg ctatactaag cgtccctttc atacacgaag aacacaacta 2044021 tggaggaggc atacatcatg agagccataa aacaaatcgt ccattttggc tgggaacaag 2044081 ccctttcatg tttgtttcct gccgttattt ttgcctcttt ggctattacg caaatcatcc 2044141 cactgccctt cttgccgcgg tatgactggc tgctcattat ctgcgttctc atgcaattgt 2044201 ggatggtgcg ttccggtctt gagacacggg atgaattaaa agtgatcaca ttattccacc 2044261 ttattgggct tgctctggaa ctttttaaag tccatatggg ctcctggtct tatccagaag 2044321 aaggatactc caaaatattt ggagtacctt tgtatagcgg ctttatgtac gcaagtgtag 2044381 ccagttattt gtgccaggca tggagaaggc ttaaggttga actggttaag tggccgtctt 2044441 tttttgcagt tgttccgctt gccgcagcga tttatttgaa ttttttcacc caccattttt 2044501 ctatagacat tcgatggtgg ttatcagggc ttgtcatcat tgtcttttgg caaacatggg 2044561 ttacatacga ggtgaatgga gctcgttacc gtatgccgct cgcactttct tttatactca 2044621 tcggattttt tatatggata gcggaaaata tcgctacgtt ttttggagct tggaaatatc 2044681 caaaccaaat cgatacatgg agtctcgtac accttggaaa ggtaagttca tggctcttgc 2044741 tagtgattgt tagctttctt atagtagcat cattaaaaca agttaaggag cagagtccca 2044801 caaaggcaga gatggatgaa tctttttctt agcatacgca tacaagctcc caaatagagt 2044861 gaaaagcaac gttcaaatgg ttgctttttt cttttatgta actctgccgg tgagtattca 2044921 tcttcttcaa atttcatcgc aacacgataa ctgattcaga ttacaactgc tttcaacact 2044981 ttgacaaact catgcgccgc cggcgttatc tcttcaaatg aatgtgcgat gacgccaata 2045041 tcgcgtgtga ccctaggaaa gatgtccttt ttaatcaatt gatgcgggac ggatgaaagt 2045101 gtaaagtttg aaatgatgcc gatacccaag ttatttttga ccatattaat caaggtttcg 2045161 gcattttgca cagttaagtt ttcctttaat tcgatgttgt attgcgaaaa tgcgtttgac 2045221 atcgcgattt catgaccgcc tttacaaaaa atgaggtcat cttgatatgt ttcaaggtcg 2045281 acatgctttt caagttttaa ttcgtcacgc tgcggcggga tgacggccac catatagtcg 2045341 ttacacaata gctgattttc aaacggttca aatggagatg ctgcgatccc gatatcaacc 2045401 gtccgatctt caacccatcc ttttatttgg tcagaggttc cttcgatcaa ttctatgcgg 2045461 atcagcgggt agtttgatct gaatgccgca atcgcctgtg gcatgatatt tgttgaaact 2045521 gcaggaaatg aaccaatttt caccttcccg tttaacagct tgttttcccg gttggctact 2045581 tgatatattt tgctttcaat tcccttcatt tgcctcgcca gcagcaatat ttcttttccg 2045641 atgtcagtca gcattaaacc atgatgttta tccctgatca ataatttgag ctgcagtgag 2045701 ctctccaggt tttttatcgc tttacttacc gccggctgag agatgaacaa ttcttttgcc 2045761 gcttctgtaa tatttaattt ctccccaact tttacaaata tgtgaagatg gttcatgttc 2045821 ataaccattt ggttataccc ccaataataa aaatgtattt cagttataca taaatgtaac 2045881 atatgataga aaccagcacg atattttaac aagaaaggcg gcttcattat ggtaaaagtt 2045941 atgctgggaa tcatatctgt cacacttatt tggggttata cttgggttgc gatgaaagta 2046001 ggaattcatg acatcccccc gcttttattt tcgggtttgc gcctgttcat cggagcagtt 2046061 cctttatttc tcattctctt catccaaaga aaaaagcttt caattcaaaa agaacatctc 2046121 aaaagctata tcatcatgag cctgttgatg gggctgggct atatggggat tttgacgtat 2046181 ggaatgcagt ttgtcgattc agggaaaacc tctgttttgg tatatacaat gcctatattt 2046241 gttacggtga tcagccattt ttcattaaac gagaaaatga atgtgtataa aacgatggga 2046301 ctggtctgcg gcctcttcgg actgttattt atatttggaa aggaaatgct caatatcgat 2046361 caaagcgctt tatttgggga gctgtgcgta cttgtggcag cgcttagctg gggaatcgcg 2046421 aatgtgttca gcaagctaca attcaagcat atcgatatta ttcacatgaa tgcctggcac 2046481 cttatgatgg gagccgtcat gttattggtg ttttccttta tatttgaggc ggtcccttca 2046541 gccgagtgga catatcaggc ggtgtggtca ttgctgttta atggcttgct ttccaccggc 2046601 tttacctttg tcgtatggtt ttgggtgctc aatcaaatcc aagcgtcaaa agcatccatg 2046661 gcattaatgt ttgttcccgt attggcccta ttctttggat ggctgcaatt gcacgaacag 2046721 atcaccatca atattatcct cggcgcactg ctgatatgct gcgggatttt tatgaataca 2046781 tttacatttt cacgacggaa agtgtgaatg atatacattt cccctgtcat ttgggcttca 2046841 tgtgacagga gaagactatt acgagaaagt cttctagaat cctgacgaca gcctattaaa 2046901 caatgaaaaa agctaatgtc tgcatgtaga cattagcttg gctggcgttt aggctggtga 2046961 gaatccagat acttttttat taccattctg gctgatcaaa ctgaaaaccg tatagacctt 2047021 ttactttaac atctccgcaa tctggatctt ttgtcaaaat caaataatga gtcttataag 2047081 gcatcgtctc aactcgatca gttgcactaa aatcaaaatg atcccccgag aagttttttt 2047141 cactaacggt tatttcatat cctgacaaag tcattcgcat gattcttgcg ttaattgtac 2047201 atccttcagt atcgaaaatg gtgaatctgt acccaaagtg agatgtccaa tggtttgaat 2047261 ttaggtcatc agacttcata aaccattttt cattctctgt cattgtaaaa ctcactttct 2047321 cctcatcttt cacgataacg gccgaagctt cccctacatg gatagtcaaa gccaaaagaa 2047381 atgtaaaagc taacatcaac atctttttca aaagagttcc tcccgatatc ttttacttca 2047441 atatattgga agggtctttt ctgatcaaga cagtcttctc caaatgaatc tttagcacca 2047501 tgaaatgagc cttaataaga acagttttaa cccaaatcaa cctctattcg aaataaggct 2047561 taccaatcta tattcttttt aaaagtttct gcatttcttt atttagctcc tagacacata 2047621 taaaaaatgc tcctataagt tcaggagcac tacaaaaaac tgctaaagtg ttttctatcg 2047681 atttattgta ttcattagct caaagaaata ttcaggcttt tgagtcttat ttagcttata 2047741 ccatgaacgc aatgtatctg gtgcaaatac atctaatttt ttcaatactt ctaccgcaaa 2047801 ttccagagga gcaattcctg atgcagtaac caaattttca tcagatactg caggcccctt 2047861 ttcatagaat gtttctcctt tgtaattagg gcagaccata ttcatatagt cgaggtcatt 2047921 gcttgtgtgc tttctcgaat ttaagtatcc ttcattcgcg aggcccaagg ttgccccaca 2047981 aattgcagca atagtcgtgc cgagctttaa agcgtcgcca acttttttca agatcggctg 2048041 atgaatatct tctccccaag tgtttcctcc gggtaaaatg ataagatctt gactcccaag 2048101 agtacattcg tcaagagaaa tatctggttt tatgcttaat cctcccaacg tagttatcat 2048161 ttctttatta acccctactg taactacttt taaagatgct gcatcttgtt taaagtatct 2048221 ccctgagttt agttccgcaa ttaaatatcc atattcccag tctgacattg tgtgaaatac 2048281 gtagagataa acttttctcg tttgcatcca ataacactcc aatcacaatt gataaagctt 2048341 tctaatagat gactttgctg acagtcattg tcagcttttt tgttgattct attcttatgc 2048401 ccttgttctc ccaacttata aaaatataag atcaattgat tctatgttta ctagcgcaaa 2048461 ggggtttgtt acactaactg tcatgggaaa catttcaaag gtaatacaaa atcatttgaa 2048521 tgaggaggcc tgatgaagtt gaaaactaaa gcgtcaataa aattcggaat atgtgttggg 2048581 cttttatgtt taagcattac tggtttcaca ccttttttca actcaacaca tgccgaagca 2048641 aaatccatag aagacacaaa catggcaagc tgtataacga ataaaaaatt tgttcaactt 2048701 gagaaaaaat ttgatgccag gcttggtgtt tatgcaattg atataggttc aaacaagaca 2048761 atcgcctatc ggccgaatga acgatttgct tacgcatcaa cctataaagt tctagccgca 2048821 gctgctgtcc tgaagaaaaa ctcaattgaa aaacttaatg aagtcatcca ctacagcaag 2048881 gacgatcttg ttacatattc tccaatcaca gagaaacacc tagatacagg catgagccta 2048941 aaagaaatct cggaagcggc tatccgttac agcgataata ccgctgggaa catcttgttg 2049001 caacagcttg gcggccctaa aggttttgaa aagtcactga aacagattgg ggatcatgta 2049061 acgaaagcta aacgattcga gacggatcta aactctgcga ttcctggtga tattcgtgac 2049121 accagcaccg caaaagcact ggcaaccgat cttaaagcct tcactttaga taacactctc 2049181 acgactgaca aacgcatgat cttaaccgat tggatgcgag gcaatgctac tggtgacgaa 2049241 ctgattcggg caggcgctcc aataggatgg gaagtcggcg ataaatccgg agccggaagt 2049301 tacgggacac gaaacgacat tgctatcgtt tggccgccaa acagagctcc tattgttgtg 2049361 gcaattctgt caaaccgctt tacgaaagat gctaattatg ataatgctct tatcgctgag 2049421 gctgcaaaag tcgtccttaa cgatctcaaa taatatgttt agccttttgc cacaaaggaa 2049481 aagacattac ttttttaact tctaccgttc attttttgat gaacggttct ttcataagac 2049541 ctctagaatc atatatttaa acaccacaaa attaaacatt attataatta acagcaagtt 2049601 ttcattttat ggaacaagta aagtttgaat ctgacaagaa ttaagactaa gcaccctaaa 2049661 atccgttttc ttttcttcca agaatatact ccttagtgca agccattata aagatacaag 2049721 tgaacataca atgcagacaa ctctcttaag tctcttattc tgtgaccaat ttgtaatact 2049781 catgaatatc cggactcact tccaatattt cgtctcgttc gaagacacta acatatcaaa 2049841 ccacttgaat taacataact gaacttgata ttggtcactg gcagtttcaa tgcaatagaa 2049901 caacatttgt tgtctcagag gttatctata tgagaattca acaatttttt tataataatt 2049961 catatttttg tatcgttgca cttggtggat ttgactcttt tcgtgtatgg aaccacactt 2050021 ttattttttc acctcttttg agatcatctg tgttatcaat ctcacttaat cctacaatta 2050081 ctatgttatt tttaaacttg ttcataagtt gtccttcaga aagattgtaa tcttcttttc 2050141 ctggagcttt tgtatcggta atgagaattg ccctttcatt gtctttaagc acgacatagc 2050201 ctactaggct ctgcatcttt gtttcgtctc cgttttgttc atttttattg cagcctgcaa 2050261 ggaaaataat gagcataatg agcactatca agcttactcc gattttaggc atctttcttc 2050321 ctcctcttta aactcatctt taaaataaac aacaggatat cacccaaccc atctacttct 2050381 ttttgcaatt cataacagca gcatactcat tctccaattc ctcaaccttc tttttattct 2050441 ttctcaaata tttgcatgtg gtagccctcg atattatccg cttactcatt tttgcgcttt 2050501 caaatatatt attgaaggcc gcttctttct ggattccagc ataaatatac ttatccttac 2050561 tgtcgtttac tatcgcaact tccattaaaa tcgagatttt tacttttttt atgatccatt 2050621 attcacttcc aaaataactt ccaattacaa cataatatat gtataaattg taaatggagt 2050681 tgatgtaatt gaagattagg aaaatcttat tgagttctgc tttatccttt ggcatgctaa 2050741 tatccgcggt tcccgcattg gctgctggca cttcgtctga ggttgcagta aaaaatgaag 2050801 aatatgatta tgacactata taccgcatta gtcctctgcc aatggacttc cagccaacaa 2050861 tagaatacaa cggttatact tatacgctta cacgtcatta ttttgattac tcaatcgggt 2050921 tttacacggc tatttataca aaagttgttt aaacttataa aggagctttt tagctccttt 2050981 ttctcttgtt ttaagcaagg tatttctttc tatgtggtcc cctatcaaat acaacatcaa 2051041 cattctccag ttctctttga cacgaacaaa atctaaagtt tggttttaaa tgctggtaat 2051101 aaaaaattca ctttaaagaa gtgccgcccg caaaatacgg cttttgtaca ctacgccaat 2051161 tttatattga aaagccagac ctcctcaaag aggttccagc ttttcttaat gtgctatcga 2051221 tcttcgttag ttcaacggga actttatcat tcggtacaaa tgcagcctcc caacttctag 2051281 ttagggctga tggcggaata tctgacggtt ctctacacac atcagacatt agaagatttc 2051341 aatgtagcct tctgtaccat gaacgcgaat tcgttgccca tcttttatca gcttggcagc 2051401 attttcaacg ccaacaactg caggtaagcc atattcacgg gctataacag ctccatgggt 2051461 catcagcccc ccaacttcgg tgactaggcc ttttatggat acaaacaatg gtgtccagct 2051521 tggatcggta aaggaggtaa ctaatatatc tccatcttct aaatccgcat cttccatgtt 2051581 taaaatgaca cgcgctcgcc cctctataac tccggaggaa acaggtagac ctacaatcgc 2051641 tccggctggg agattttctc gtttatactc acctgtaacg atttcaccat cagacgtgat 2051701 aacacgtggt ggagatagtt tttcatataa tgtgtactcg tcttttcgtg tactgatgat 2051761 ttgataatcc agtttatgtg tgcgcacgac ttcgtgaagt tcttcaaaag tgagatagta 2051821 tatatcttct ttttcatgaa taacgcccgc ttctatgagt tgttcggctt ctttcagtaa 2051881 agcctgctta taaacgaagt atcgattaac catgccgtat tttggatatt ccctaaaccc 2051941 gctgaaattc cggatgatat ctatcgctcg ttttgtttct ttggcttttt gttcaccatc 2052001 cggtaattgc ttcaatcgat ctaataactc ttgttctttc ttcaaagctt cctgtcgccc 2052061 ttgctcaaat ttccgatggc cgacattagg ctcaaaattt ttaatattat taagaatcat 2052121 tgggacaagt gtagttggtt tttcgctcca tcgagttctt gtgatatcaa tctctccggt 2052181 acatcgcatt ccgtatttgc tgagataatc atagatcgcg tctcgggttt tgcttccgcc 2052241 atcaaactta gccagttcat ccaaaaagtt atcatctttt acatgttgta agtaatcaat 2052301 tacctctgga taaggacgaa tcacatctgc gacgtctaat agcgcaagac ccatttctga 2052361 agtaatatta tggggtacag attgagaaag cgtatctgct gcgttttttt cacctaacca 2052421 ctcgttcatt ttttcgttaa tccataatga agcattcata gcagttcgaa ttagaaccga 2052481 actttttggg ttaaataaaa tcttctttaa ttcctgaata tcttccagaa taaaacgaaa 2052541 taaatctgat cctgatttcg tttggatgtt ttgttttaac tcttctatcg atgtttgact 2052601 gctctcaatc aaatcagaca cgattgtcgg atcgttttca acttgagccg gcatatctgc 2052661 attgcctctg ctgggatttg gtgctgtttt atcatttggt atcgacttta tgaaatctcg 2052721 tcgctttatt atggtcataa gtgcgtcttt taagagctga tcgtgctgcc ccatgccttt 2052781 taagaaaact tctctgctgt caggggatgc cagatgatgt gtgacatcaa caaatagcct 2052841 tccaccggct ttacgcatgg gtgcaacagt cgtcaacaga aaaaaagaca atcccagtgg 2052901 ttttatggga tccgtcatca tttgttgatg accaacagaa atatagacgt gattttcttg 2052961 gtcactcgct tcagggatgg ggaataaagt agtgattgga cgactctgta caatataaaa 2053021 agtatcgcgg gccaaacacc attcgatatc ttgcggctgg ccgaaatgag cttcgatctg 2053081 tcttccaatg cgtgccagct gtaaaatttg ttcatcagtc agtgtttgag ccttttgctg 2053141 atcagaatcg atctgctgtg tttctgttcc gccttctttt cgtccgtaga tagccatttt 2053201 tttagttgct attctcttat cgatgatttg cccatcctgt actttaaaac aatcggcaga 2053261 taccaagcca gaaaccagtg cttcaccaag tccaaaaccg gcatcgatgg ataacacctt 2053321 tcggttggag gtaatcggat cagcggtaaa taaaatcccc gaagcctgag ggaaaaccat 2053381 cctttgaacg ataacggata aatagacttg gctgtggtca aatccatttt gcatacggta 2053441 aataaccgcg cgatccgtaa atagggacgc ccagcattta ctgatatgct gcaagattgc 2053501 atcgacgccg gtaatattta aataggtgtc ttgttgaccg gcaaaagaag catgtggtaa 2053561 atcctcagca gtcgcactag aacgcacggc ataggcatgt tcctcgccaa actgggagag 2053621 atattgagcc actgctttca caacatcgga aggaatgtct acttccataa tgatttgccg 2053681 aatcttccgg ctgatgttac caatctgatc tcggtcctca acttttagca tggtcaattg 2053741 atccaacaac acttgtaacg tttcgttttg ttcgatggct ttttgatatc ctactgttgt 2053801 gacacaaaat ccttctggta cttgtatacc ttgaattttt gataattccc ctaaatgtaa 2053861 cccttttcct ccaacgagcg aaagctgtgt tttttcaatt tcatgtaaac cgagaaccaa 2053921 agaactcatt ctacatctcc ccttcaaaaa aaaatattga caagagcttc ctagcaggat 2053981 ataataaaat tataagatgg atatctataa ctttttaact agaaagcgca cgtagtgtga 2054041 ttatatcacc gtgtctgttt ttgtgcaata taaaaagaac ctgggaaatt tcaccaggtt 2054101 cttttcttaa tttccatagc tagtcgcatt aaaaaacttg gtttgagctg attcaatcct 2054161 ctaaggaaat cctaaagttg ggttcttttt gaacttactt gctttgttcg tagagtcccc 2054221 attcataaat tggacttttt gttcttaaca gtcccacctt taactagtat aaagttatga 2054281 ggatctggtt aactactaga tatttttatt ttgaataagg cttatgtttg ataaagaagg 2054341 gttatgtaaa ggtgtctgtt gtgagcaagc gctgactaca aaaaattgat agcattctca 2054401 tttaaatacc attctattaa cctataggga aagttttaaa accagatgga gaatacccta 2054461 cctccagcaa ttccaaggcc gttcacctag tagaaaacaa cctttaacca ttactaacga 2054521 ttttaataat cattgattat aaaacttctc aaggaacgat cagcagcccg ttagctaccc 2054581 ctgattaagg atgatctgtt accacactgt tacgttagaa cttccactac tttgatatcc 2054641 ttctgtcgcc atgacttggt aagcccaatt actgcccaga ttcattccat ggctcttcca 2054701 tgcgttcaca tgattgctga aagtgattgt agcgttgctt ccggttggtc tcttcgactg 2054761 gcgaacactc cagtactgcg taaaagtagt gcgatcgcca tcaatggaag gtgcgttata 2054821 acgtgtagtt gtatatatgt catatgtacc cccatcactt tttacagtac ctttatacgt 2054881 tccagtaggt ctataagtac cccatgaatc cactacataa tattctatga gaggtgatct 2054941 cgtccaacca tataaagtta aatatccatt gccattcggc gcccaaactc cggcattata 2055001 gtttatcgtc ctaaatggcg aacctgtagt ccaaccttta ccaacaacaa aatttccggt 2055061 attagaccaa ttaacactgt aattcccgcc agacccattg acagcgttta ctataccgcc 2055121 cccatcagtc caattttgcc agtagtctgt gctagctgca gaggcggttg ccgaaaacaa 2055181 gctaatactc attaaagctg ccgataatcc aactaagaaa ttctttttaa acttaaacat 2055241 atgttacctc ctataatatt ttttccgact ttgaggtagc actcgtatac atttaaaaca 2055301 ttcttaatta ctaacgccaa agcttttgat cgtccccttc agtataatac cacgaattca 2055361 tgagcaaata ttaaaagtat ttgtaattca attacaaata cctagaaaca cattataagt 2055421 ggtcttcttc caccatatcc tgatcctttt ttcgcaggat cacaattctt gtttctaatt 2055481 cagatggagt aatatctgca atgaattccc attgaaccat ttcaaataaa ggagatatac 2055541 attagagatt gtgaaattat tgtagctgcc gcttgtctaa tgaagggaag caaatttatg 2055601 aagaatatga agaactgaag aagaaaacaa ttaaggttat actaagaaag aactgctcaa 2055661 ttaaaattat tgaccaaatt tgaggatgat agcttagatc agttttacaa agaagttgca 2055721 agatttttat ttgaaagggc tctgaaaaag aaaaaaaaga attgacaatc agggtaactg 2055781 tgggatgtaa ccgagcctcc aattcaaaat aaatatcttt aactttcttt ttttatttaa 2055841 agagggactg tatatccctc tttaaaatta agctttagat tgctgctgaa agtaataaaa 2055901 attgtacttt tgatcaaacc cttcttcgct accacaaaga aaaataatga attcaataaa 2055961 tgcgataata gaggggatac cagtccagca aaacaaaata tatagaatac cttgtcctac 2056021 tcttcccaaa taaaacttat gtattcccag acccccgaag aaaaatgcta ataatgccgc 2056081 tacaattttg ttcttcttgc ttaccatgac ttcctcctag ttcattgcta ccatttttaa 2056141 agtaatgctt tcacattata atgcattttc cgccagaaat cgtgaaaatt ttgaaattct 2056201 tttgagattt tttattttat tgagaaatga aagctcatat aattgaacta gatggttttg 2056261 ggaggcattt attcaaaatg tattgccaaa gattacggca attacgaaag gcacacaaat 2056321 taacaatgga acagttagct gagaaaattg gaattgcaaa atcaagttac ggcgggtatg 2056381 aagctgaaag caaaaaacca ccattggaca agttggttat tttagctaga ctatatgatg 2056441 tttcagttga ttacatactt ggattaacag atgatcctga tcctaaagtg gaaagaaaaa 2056501 atctaaaaga gtttttagaa aaaccagata ttcactggga tggatataaa cttacccctg 2056561 agatattaga tcctatacgg aaaattttga agttggttac tgcaaacaac aattaaaaaa 2056621 gccctcataa gggcttttgc ataaaacaat tatttcattg aattttctgg actcatttca 2056681 agaagtttat tcatgatgat agctaaactt tcaccagctt tttgtagctt ctcacctgct 2056741 tttatcagag taattaaagc acttaaaaag tccactaagc tattttgatt tattgcaact 2056801 gtttctttat aagctttgta agcttcttca aactgatcaa attgcacacc tttcatagca 2056861 acaacagcta atttatctga aatatttcca tatgactctg ttaaactaaa aaatcttttg 2056921 acattgatta gtaaggcaat gcactttaaa taatcgtgcc ccagaccaat atgtaaattg 2056981 cctgcagcaa acagcaaatc gttcaaaact gtgtacggtt caccattcct tgcaactgtc 2057041 tcaatccctt tgtataagta taataaaaag acaaatgaat ttttatctgt ggaacgctca 2057101 ggtaataagg acactataat aacttacttt aagccaaaac atccaaataa aaaggctggt 2057161 tataattatt ataaaaatca ataggaacta taaatatata aagagggatt gctatgccaa 2057221 aattatatac atgtttaatt tgcggatata aaggattaat tcaaaaccca ttaaacaatg 2057281 atggtgagta tcaaaaaaca tttgatatct gcccttgctg tgattttgaa tacggctaca 2057341 gtgaagatca tgacgtaagc ttaggtttta ttgtaactcc agattattta attgacgctg 2057401 caattcagtt ataccgaaaa cagtggattg agaatggaat gaaaactgca aatcctgaag 2057461 atattccaga agaattaaga aacggtgact gcttaaaatt cgaggtgttg ttaaagcaat 2057521 tgaatagcct aaatctcgat actgaaaact ttgaaatcaa gggatttaat ggttattaag 2057581 cagatccaag cccccatatg ggggcgttct tattattgta cagtctatca gaactattta 2057641 tagaaaaact atttaatgta ttgtataaat atcactgacc ttttctttct ccattcaact 2057701 tccttaaccc tcaactgttt gctgctgcat cacattcctc ctttttgatt tttgtgtatc 2057761 aagcctgtac aatattcaaa aaccctaaag gatgatgaac atgtgtggca agttcacttt 2057821 attttctgag tttgatgaca tcattgagca attcaacata gatcaattct tacctgaagg 2057881 tgaatatcac cctagctata atgtcgctcc ttcacaaaac atcctgacaa ttatcaacga 2057941 tggatctaat aaccgtctgg gtaaacttag atggggtctt atccctcctt gtgctaaaga 2058001 cgaaaagatc ggttataaaa tgattaatgc tcgtgctgaa acattggccg agaaacccag 2058061 ctttcgaaag ccgctcggaa gcaaacgttg tatcataccg gctgacagtt tttatgaatg 2058121 gaaacgcctt gatccaaaga ctaagattcc tatgcggatt aaacttaaat cgtcgaatct 2058181 ctttgctttt gccggcttat atgaaaagtg gaacacgcta gaaggcaatc tgttgtacac 2058241 ttgcacaatc atcacaataa agcctagtga gcttatggaa gacattcatg atcggatgcc 2058301 agttatccta actgatgaga acaaaaagga atggctaaat cctaaaaata ctgatcctga 2058361 ttatctacaa agcttgttgc tgccttatga tgctgatgac atggaagcat atcaggtatc 2058421 ttcattagtg aattcacctg agctcattga atcccattaa gtaccactgc catatcgctt 2058481 tatataccac ctcctcttag ctaatatgtt ctaagtagga ggtggtattt tgtttgtatc 2058541 tccaatgcta ttgcattcaa taaaagagcc ttttgatgac gagagctata tcactgagct 2058601 taaattatca agactaaaat taaaataagg gctcatacat agttgatata tataatatgt 2058661 attgagacct ttattgaaca aacgccccgt ttgttaaagt ggaaatctct ataattaata 2058721 gccgactttt aaaagttcca atctaaaatt atcctctaaa tcggctagct tcattaactt 2058781 ctccgatata cctttccaat ctttatttac agacatagaa tgacatatcc caaacacctt 2058841 agcctgttca gtcttcaaca ctgataaatg tgaatgccta tctttaaaat acattgcata 2058901 atcgttggcc cttcttgcac ttaattggaa aaggaagaat gttgtatgcc ttatagtatc 2058961 agctgtaata ggggcattta ataattgatc agcataaaaa caaattgctt cccttccaat 2059021 taaccctata tccacttttt cgaatttccg ataagttctc ttaaaataat caattgctct 2059081 ctcgtatatt tcgttattgt ctaatgtgac aacctttttt gctgtagacc aatatttatt 2059141 gattcctttc ctatacggaa tcctttccgc catccaagcc ttcttaaatt ggtccagtga 2059201 taatggaaca aatggaaagc ctgctggatc ttgcacataa atattttcat tatccatttg 2059261 gtaccctaga acataatggt cagaaccatt taaattttta tgattcggat ggtatgttag 2059321 ctcccccata tctaaagggc ctagaatgac agggttttgt ttgatttgct gttttaataa 2059381 cggaaatggg tcatctaagt cactagcttg ctgatgttct tctgcagtaa atccaaggat 2059441 gtttaaagca taattgatac catcatcagg atctctcata ctaaaataaa ggtttttttc 2059501 atattctatc atggcaccta acccaacacc agttaatatc tctacaagtt gaggagatac 2059561 attttctcct attgatgaaa gaaacattgc agttgaattt gaataacagt aatggccatt 2059621 tcctatatac actaacatca cctccgggta gataagttaa ccttacaatt ttgaaaattg 2059681 aaaatccata ttaaattgct ccgttctcgt attcatcatc tggatcattt ttatcaacaa 2059741 taatgatctt ctcgccaatc tccgttttac gatcgacctc tacgtattcg cgcttgatgc 2059801 tgctaagtgt ttcgtcagcc agtacgtgaa tcattacagt tgagttcgct ttaatttccg 2059861 tcatttactg caccctttat atttttttta tgttttttca attcttttta gattttcata 2059921 ttggatttca ctcttttaat tatagaggcg tgtcatacac atgccatcta agagagatag 2059981 gacaattttg tcttggaggt gaaagctaat gaattttctt cttgatcttt ttacaaattg 2060041 gacttttgat aaagtcctgg attatacact agctgctgta atttggtctg tatttaaatc 2060101 cagatcaaag cagaataagt atccaggcta tttcgagaaa atacgccgct atagaaattt 2060161 acatcccctt ctgcgatcgt tatcgatgcg tgtactttta tcgataacga tccatcctta 2060221 tatgtttagt taaaaactat cttttattta gacttaatgg gataaaatct tcattgtaaa 2060281 actcttccca ctcagcaatt aagtttctat aatagttttg gttagagtcg gttggcatag 2060341 attcaatatt gtcaaaacca ttaataccga catctaattc tactgtcact aatccttggt 2060401 aaaacttctt ataattcttt ttaattactt tgaaaaattc aacatcaaag aagtcttcat 2060461 attcagttgc tccactccaa gaatcataag aggacttaac acgataatta aaaagaacca 2060521 aaactaactc atctttcaca tcttttgata tttgctccat taattgattt agtccttcac 2060581 tggcattaaa atctacaatg cttaatcgga agtcaatcca agtaacagct tcatctttta 2060641 accttccttc tccgtcttca ttcacttcaa ttaatacata tctgtcagcc ataattccct 2060701 cctaatttat ttgtttaaaa tcacgatttt aactatttat gatccattag tcacttccaa 2060761 agcaacttcc atttaactca taattaatat ataaaatgta aatggagttg atatatttga 2060821 accttcgaaa aattttattg agttctgctt tatcattagg tatgctggta tctgctgctc 2060881 ctgtcttggc aacaagttct tcgtctgaag tgatagtaaa aagtgatgaa tatgattatg 2060941 acaccatata tcagcttagc cccctaccaa acttcaagcc ttctattgaa tacaatggat 2061001 atacttatac tctcacacgt tattatttcg attactcaat tcagttttat acggctattt 2061061 atacaaaagt tgtttaaact tatagggagc ttttttagct cctttttcac ctttttaagc 2061121 aagatatttc tttctatgcg gtcttttatg tatgaaatca aatgctttcc ctaattcctt 2061181 ctcttctgtt accgctgagt ccatatctta tattgcatct aaggtttagt cagtcgagat 2061241 cattgaatat atagtacttt actcagaaca ttttgcttat taaggacata ataagtgttc 2061301 gtattaattt ttcctgttac gataacgatc aaaaacaaaa taatttatct cattttaaga 2061361 cagaagttat tctgcttttt caaaaaaata ttcttgattt tccctttttt agatgcatcc 2061421 ataaagcatt cgatcataac cattatatgt aactgaaatg caggtataag agttattata 2061481 tagggattac actaccatta tctgggggtg tattaacatc caaatactca aaagcaagaa 2061541 caaatgtacc catagcactt ccatttccac accctatcca aattttcatt ttcctaattc 2061601 cacatcaaaa tcaccctttt tcacatcgta atcactatcg taaaagccta tagtatcaac 2061661 gtttttcctt cttaaaattt tcttttttta taaatatctt cccaaaacaa ccactttccc 2061721 ctactcccgc ttatgtttta cgatcgttta ccccctattt actaattaaa gtatcaaaaa 2061781 ttcttatgtt tactgtcttt ttagctcatt ataaattttt acgataagca attgcctttg 2061841 cttttggata tgacttgact gtatttggtg acgatttaac agagaaattt aatgctcttc 2061901 tgactttttt aactgcattg ggcattattg ttgatccaac aactcaaggt atttctgata 2061961 gtgaacaagc aatggattat gattcaccga gataaacccc atacccttct cttgattgag 2062021 gagggtattt ttttcgtttt ttcaaatgaa aaaattgcag aaaactttac atccttttac 2062081 aattttttca atgactatgt tatgattgtt ttcgagagat ttttgaaatt ttcagaaaga 2062141 ggggtttaaa tgagtaagat cgcttctgaa gttgtcgcta ctacactgaa tgactggtac 2062201 attgctataa aaaaacaaaa ggttgatgaa tcaataaaat attattcaga gataaagaaa 2062261 ctttttgatg aaatggaaga agatcaagaa gttcttgcgt attatagtct attagaagaa 2062321 agacataaaa tgttgctgca ttcttcacga ggagagcctt tacaaaagca cacctatttt 2062381 actgaagaca atcaaaactt cataacaaaa acaaatgata aattagaata caacttttat 2062441 ttatttgaag caatgtacga ggcatacaac aaaaactatg atcgagcaat taacctatat 2062501 ggattagctg agaaaaagct tgcagaaatt ccagatgaaa ttgaagcagc tgaattttac 2062561 tctaaagtct cttacttata tactcttgtt aaacaaagca ttgtggcaca acattatata 2062621 aaaaatgcaa tttcaatata taagcgacac cctgattata aatgcaaact agctacatca 2062681 acaatgattg cagctgcaaa ctatgctgat atgaaacgat ttgaggaagc agaacaatat 2062741 tacttagaag caattgatat tgcaaaagaa acaaaagatg aatttttaaa agctcaatta 2062801 tttcacaatc ttagtatcgt ttattctgat tggaacaaac ctgataaatg cattgaatct 2062861 cttgaaaaag caataggaaa tgaatcttgg ttacattcga tttattatat aaattcttta 2062921 ttcatgatga ttaaagaact ctttaaaatt gacgaaaaaa tgaaagccat taatttttac 2062981 aataaagcac aggaaagact catattaatg gagaataaag tatacgaagc caaaatcagc 2063041 atcctgtata acctttattg tggggaatta aaaaataatt tcaataattg tattagtaat 2063101 attgagtttt taaaacagca aaatgaactt gaaagtgtag atgaattgtc ctacatagct 2063161 gcaaaaaggt ttgaatcaat aggtgctttt gaagaagcaa cgagcttttt caatgcgaaa 2063221 atttgggctg aacagaaaat gaatcaggtg gagggaatct tatgaaaaaa cttgtgcttt 2063281 gcgtatctat tttagctgtg attttaagtg gagtagcttt aacgcaattg agtacagatt 2063341 caccatctaa catccaggta gctgaaaggc cagtcggagg ttaaaaaagg ttgattaatt 2063401 aatttagccc tactcaaaca tttgagtggg cttttatttt atgatttatg tccaccggtc 2063461 agccctgctc tgtggagcgc agtacctgca aacgtaactg agatacttct cactgttttt 2063521 tgcccgagta aaacttatta aagaacatca agcaacactt ataaatatcc atcgtgatat 2063581 ttgtgggaaa atcaattgtt ttggatcgat gaaaaccacc gccaagctca tctttactgt 2063641 atccaattcc tagacttatt gttcgaccaa ctttattata tgtacgtgcc cttcttgcga 2063701 cttcctcaca aatctccaag agcacagctt taatctcttc tctctttgta taatccctaa 2063761 acaaaatctg actcttacca aaactaatct gcccctgcat caatggagct cctatttcag 2063821 ataaatcaat tccgtgagca tgatagtaca actggtttcc cattattccg aacttctttt 2063881 caagcagctc taaaggaaat ttagctaact gacctacagt tgatataccc attcgattca 2063941 gatttctttc catcctccct cctatccccc acattttaga caaaggtcga actttccaga 2064001 gtctatttgg cacatcttca tatctccaac gtgcaatacc actctttgtt ttcttactct 2064061 ccaggtcaag tgcaagctta ctaagcaaca tattgtcacc aattccaact gtgcacatca 2064121 aaccaaattc tctccacatg ctgctttgga ttgctttggc catttcttca ggattctctt 2064181 ttcctgcatc taaaaaagat taatcaattg aatacgtgtg gacacatttt tcaggaacaa 2064241 atctgtaaaa cagctttgta atctcagttg aaactctgat gaaaagcttc atttgtggat 2064301 ttacaatgta tattcttgga tcttcaggta tctcaaatag tctcgatcct gttttgattc 2064361 caaaatcttt tttaagtgca ggagatgcag ctaacactac acttccctgt ctatccgtat 2064421 tccctacaac ggcaagataa catgttaaag gattaagccc cattgctaca gccgatacag 2064481 aagcataaaa ggatttcata tcgacacaga gtatattctc acgtggaaat tgtgagtaat 2064541 cagtcattgt atataactct tatgatgtta ttcatgttga tataaactgt attgtcgttc 2064601 tggtctttta cgtgaagctt ttgttgttca aaattaatgt aatgtactct gccggtaaca 2064661 ttttcaacaa atcccttgtt aaagagtttg aatttcaact ctttattaaa ttccaatgcc 2064721 tcagaaacga gaatatccat ctcatcaatt tgtttgtcat ctaaagatgg cttttcaact 2064781 tttgatccat caatcaaatc ttgtttaagc tgtattaatt gttctagcat cattgatgtc 2064841 cattgatagt tcctcgatcc ctaaacatat cgactcactc cttgattgat ctaatatcaa 2064901 cagaacaaac gttccttatt caatatagat cagaacaaaa gttcgatgta aatgttggta 2064961 ataaaatata aaggtcaata atgatatccg tagtattaat aaaggagaga ttcttttcga 2065021 cgagggagag tgtgatggtg aatgaagaag aggttaattg gatttttggt cttagttcct 2065081 gctttgatta tgtggggtat aactttaatc gaatcaaaca aaaagacccc tgtagaagtt 2065141 ttagaaagtg cttgggatga atttgggtta tttagttttg aaattggaat aacagatccg 2065201 gcaattacaa taggcatgga tcaaaccaaa agtgaagcaa aactccgtga atatttaaaa 2065261 gataatctgt ctagagaagc caaggaaaaa tataagattt atatattcaa ggatgatact 2065321 gataagctgg agaaagagca tcaagaatat ttgaaagaaa ataatctcaa taagtaaaac 2065381 gcccagcaat taaaactgga cgttaaaaaa cattagttat tctttatttt tttttagtat 2065441 tcacacgtaa tctctctcta tcttctttaa aagaggatat gtagttttta gactctaatg 2065501 cagtcaccaa cgctttatta gttctattat ttgagatctt tattcgtctg cctttttcag 2065561 caatttcaga gtaaggttcc cctattttag ttaaaaattc agtaattgat tcattatcaa 2065621 tatgctttat ttgtccagct agcaacgata acctagtatc caatgttgta ggtgattcaa 2065681 gcaaaaaggt tagtagttca ttggtgattt tcaggttatg ctcattaata aaataaattg 2065741 tatctttaag aatatcatta tttccatctg tcaaacagtt agaatttaaa tgttgtacaa 2065801 atatttcttt gttaaattga gagagctcgt tgctatctat gagttgcttt atatcattgg 2065861 catcaaggga aaaatcacct tgtttatcaa taaactcgtc agggtttctc aaagcgagtt 2065921 ggatatgaag tgtatcaaaa tttaatttta actctttaaa attttccggt gttagagata 2065981 acaaatcatt atcaatcaat aattttgctc ttttttcact aacatttccg agcggaaagt 2066041 aaatccaact ttgaatacta gcaattaaca cttcgaatgt ttcgtctgta atatcccgac 2066101 tattaatgat ttcttctgag atatcttcta aaatcgcttc gtcaaattta tcatcaaacg 2066161 cctctatatt atttttagag agctcttttc tattaacagg attgtttaag aaagctatta 2066221 agaaatcagg cattttttta ttgtattcta cataagaagt aataacgttt gaccagcatg 2066281 caaccatttt attttcacgg atcacaattg gccataactc tttaatcaat tcaccaatat 2066341 ccgagatggc aaaagttttt ttcatgatca ttgcatgctt tactctctta tctaaatcct 2066401 cccgatttaa taactccaga aaactttcct ctggttcctc aatctcctca gtaagtaaaa 2066461 ctttttcaac aaatatatca atattgtcat ttacgtaatt gataacagcc tgctgatcag 2066521 agtttttaac tgcagcatac gttatattgg gagcatcatt taaaataact gataaagttt 2066581 tgatattaat ttcgtataga tttcgttgaa caacaaagtc atatattgtt tcagaattta 2066641 gcaaatgatc caaactttta aatttaactt ggagttttaa tagtagttct tttattttct 2066701 cctcatcaga tactaagctg agaagattta agtacttgga taatgtgaaa gacatgaccg 2066761 actctttatt cattcggata atatcagcta tatcagcata tgtaagtata tctgacaagt 2066821 attcctcttt tttctgttgt gtataattgg atctaagttc aataaaactc caaaaatcat 2066881 cccatttact agatatcgat tggataaagg cagctttatt tattgccctt tctttaaaac 2066941 catctatgaa tgtaacagat tctttacttc catttgcaag tcgctcaatt atgctatcat 2067001 aataattacg gtattcagaa tgatccatta tatagtttaa gagatgaaaa ttaagtacct 2067061 ctatttgctt aaattcagca ccaactaatt tgctcattat tttaccgata ttatccagct 2067121 caaagctgta aggcaatgac tcgtggtttt taatactaaa tacaaattta atatcggaaa 2067181 gacttaaact ttctggatag aagtaagtga tgtaatggtt atacatttca tcaatatatc 2067241 catgacgtag caggtaaaca agtaattttt tctcgtaaag cttatcagaa aatacatcct 2067301 ttgaattcat ttttgtaatt aatacttgta aagattgcgc tcttatttct tgcttttctc 2067361 tctctaattc caatagttct ttcttgaatt tttggatttc atttttctct atagccttga 2067421 tggcatcttc tctttcaaag tagttcggtt tccgaccaaa aacagttgca atttctttaa 2067481 ttgtcgctgg accatttcta tttcttaaat aacaatagat agtatccgca ttttttaact 2067541 tctcaaaaaa ccgatcttta ttagatgtat tgcctctaaa tacctcgcca tctatattaa 2067601 tatcataatt agaattcaaa tttgatattt ctaattcgct caagtatata aaatttaatt 2067661 cagcaattga ttttaaagac tcaacttcta tattcgctaa tttcctctct aattgttgta 2067721 ttttagcatt aattaatttt atttgttcct caattataag ttgttttttt tgaaagattt 2067781 catataccaa ccctttgtta tattgtaatt tagaaaaatc cacaggataa atatttttgt 2067841 agattatcat tgctaacatt ttgttaggat caagatcaat tgcacttagt ttttgttggt 2067901 atataacaaa ttcattaaaa atattcttta atactctcat gtcatcaatg taaattgtta 2067961 catcctctaa gaaatgagtg tttatcaaat cagaatatgg tgaatgtttt attttctttt 2068021 taagtatgtc tcctgaatta gatgcattaa taattggtat tactgggata ataaaatcaa 2068081 aaaattttgt gcggtctcta gttaactttt cagtgtctgc atctccaaaa atatcatctt 2068141 ttatcgcata tataaaaaca acacgtctat ctatttgttc tgaattattt ataagttcat 2068201 ttaattctct taatctttca aaaataccta tattattaaa gcgatctaag tcctcaaata 2068261 ttacaacatt atacttggag gcttcaaaaa aatataatat ttcatctaaa tatttatcaa 2068321 atatagaaga gttttcttcc cctgtatttt tttctaacgt tgtattagca attgtaacct 2068381 tattcaattt taagttggca cggacaaaat gataaattct tttatatgcg agtagaggat 2068441 atactataaa gaacagtgct aataatatag tcagtcgtat ttgttgctga tcttcagtac 2068501 cgagactcct tgaaactaac gtctcagcat atattccttt aagtgcatca ggtttaaaaa 2068561 ggtagatgcc aactataata aatgcaaaaa agaaaatcaa atttataatt atgctcttag 2068621 tccttatatg cttaattctt ttaaacctag aaaagggaat ggttctatcg tgtacccggt 2068681 atatcatttg ttgcaagatg cttttctcta acttattctc catatcatcc gtatctgtgt 2068741 tgaatgtagc taaggatata tttaagaaac tatattccct gctgtattgt ttttgaaagg 2068801 tatttaatat gctacttttt ccagacccgt agggaccagt tagggcgata tttttcactt 2068861 ttttattttc taacccccaa cttagtgctt tagaatattt tccatcagtg tcgacatcat 2068921 tgctaggaga aagatcttca aaaaggcttt cttccttaac attaggttct tttagtctaa 2068981 tcagaagttt ctctaaccac tgcacaaatt tttttttgat ttcccccaaa aaaaacaaat 2069041 cctttctaaa ctttcaggtg taatacgaat taataaaact ggagcaaaga actaaataaa 2069101 tgagtatgta gcaatgacaa atcatttctc ttccatctaa tatagtcctt tatcgccagt 2069161 tgaaattcac tattaattgt aacatgaaag ggcattaaaa gtttctgaaa aaaagatgat 2069221 caataaacaa cacagcgccc aattacagga ctgtttcata tttaaattga atttttataa 2069281 gcattaattg cttcatttcg cagcagcata ttatctttgt taaccatgcc taagttgtaa 2069341 gcttttttga taatatctaa tacctgagaa tctaacgccg aaagattacc gcctggatta 2069401 aatcttgatt tccaataatc taaagaatta tttaggtcaa gtgagctttt tttgttctcg 2069461 ggtttaacta cttcattttt ctcaagtgtt tcacagaatt cactaaaacc aatggatcta 2069521 ctgggagctg agttatttcc cccgtatcct tctgtagcca agctgcaaaa tgctaagaat 2069581 tttggatcat aaataagatc gcttcagttt acatttacca ctgataatca caatcctctc 2069641 aaagcttttt ataattgtag caccttttcc atttttacac atattaaata tcgacaatca 2069701 ttcaaatgat ttaataattg aatacaaaaa agaacctgca ttttgcaagt tcctttcacg 2069761 ttgtcaatat attgtgaatt tttaacgaca agggcattta tgtatagtat gatatttcct 2069821 gtacagtaag ttttgctcac tcgagggagt cttgctcatc ccctaatgaa aggggtgatg 2069881 ctatgtcaac attccaggca ttaatgctaa tgcttgcaat cgggtcgttt ataatcgccc 2069941 tattgacgta tatagaaaaa atagacctcc cttgagcctc agaacctgaa gggataggcc 2070001 tacctagaac cacatcgagc aagccctttg atgggcaact ttttgtacag agccggggtg 2070061 ttggtagcac ctcggtcttt tttattttat gcatttctca ttaaagaaat gcactgtaat 2070121 gtattgtaaa actgattata acacattttc cgtgaaatgc attacaataa acctcaagag 2070181 acttggaaag cttttttatt gtttcttgta acgttataat gatctaaaat agcgcacaag 2070241 cctttataca tcttcatcat ttcttactct tctagctcgt ctttcaacat tccaattccc 2070301 aatctttccc cagacattct tgttagtcca tttccctagc ttagttttat caaaccattc 2070361 ctgaaacaaa gatatttcat ctttcctttg cattgtatct tttaaaagga aataatgtat 2070421 tatccaaaag atataaagag ctgaacaaga aagtccaaaa ataagtttat ttacctctaa 2070481 ccaatttcct aaaacttgtt cgcctaaata tttatcatat agaaggggta taaaagcaaa 2070541 tgctgaagca ccgacaaaaa aagctagagt ttctttaaac catctaacaa aaacaaaaac 2070601 agcgcttaaa atataattcg ttctaaaaag aactttatac caattataat tcttgtttag 2070661 agtaacaaat atacttctat attctttatt aactgcttga tctaacattc tcattttata 2070721 aaataatttt ttcctattct cgctgttctt gtttaaaata tactctctga aacaatcttc 2070781 tgtattcaaa atttgatcta tcaataagat gtttctaagt tttgatagct tccccttttt 2070841 cccactatat tcttcgaaaa atttttctat aaggaccatt ttatggtttt catcttcttc 2070901 attctttatt tcttttaggg aataatacat aggctctaaa attttttcta atgtttcacc 2070961 tgattgagag tagaatcgtt ctatactttt ttgtctttga ttgaatagca atgcaactat 2071021 acccgtaatt actgcagtaa gaataccatt ttgttgtatc caattccaaa tatctaataa 2071081 ctccaattaa gcttctcccc ttctctctga atttactttt aatacgggct aaaataaaaa 2071141 aggtttcata taaaacggga ctagaaaact tctgtcactt taattattta atccaataaa 2071201 ataagctctc attgcgagag cttattttat ttagattgag gatgtgcaac tcaagccttc 2071261 tattgcgcta tagcaatact tttgcttaat cgtcccagtc ttcatcctca tcccagtcat 2071321 ctttcgcttc ctgaatctta ttataaaaaa attcaataaa gctgtctgca acagtatctt 2071381 gataaccaat taccctatcc cattcaacta cagggcattc tccgtctttc attttatttg 2071441 tatctagaca gtaagcaaag taatcaacat cttcaataac cacaagtcca tcagtaaggc 2071501 catagtgttc tttatattca ttagttctat ttacaactga tgcatgatca aagttgtagc 2071561 ctaaaaccaa aacgccgaat aaaccaccag caccgtattt ttctaaaaac catttataac 2071621 tgttggggag atcgcattgg aggttttctt caatgcgacc aatgttttca tgacttgcac 2071681 cttctgtaaa tatagcattt tgtttatttt cattaataaa gttctcaacc ttcgaataaa 2071741 tcatataaac acctcaattc tcattttcaa attgtttcgc tctccatttc caatatctct 2071801 ttctaaagct ctcgtattgt gcttttaaaa ccttatcatt tctaaaactt tcaccatcag 2071861 acttaagctg atgaatgaca tcactatatt ttgtatgtaa gctgttcggg atttcaagca 2071921 ttgggccagg ttcttcttga atcaagtgat gtaaattaat ctgtgtaccg tcttttgcat 2071981 aaggggcatt cccgtttttc attagctgaa gatttgtaac accgaattct gttttttgat 2072041 taatatcaat atctttcata gtatacactc tacggcttac atctttaact ttccccttcg 2072101 cctttacctt cccctctatt tcatatgcat catacttttc tttatttagc caaggagggc 2072161 ttttcttttg gccagtaaac ggttttcttg ttccatccgg tattttcttc gcattagtca 2072221 aaagttcatt cttaaggttt tggctatcaa ccacattgta tggcacgtta tctgctagag 2072281 caagcttata cttagggttg taaggcagca aatctggaat cttaacgtcc ttgattttct 2072341 tacctgcttg acttgcttta tttattacct tgcccgctgc atctgctttg ttaatggctc 2072401 ctgcaccttt tgtaccaaca acagctacag ccactgaacc aatagcatag gtaacccatc 2072461 ttgatctaga ataggcatct ccattcacca tatccttttg atatgactct tctattgctg 2072521 ctgaaatggc atcgtatgtt ttcactggat gcatagctgc attacccagt gctgagagtg 2072581 tttctcctgg atcggtgatg aagtcccata tgccggttac agtgtctttt cctacatcgt 2072641 ataaaccaac tcctacacct tttacgatat cccaggtgat ttctcctgct ccttctagct 2072701 gcttcgcttg ttcaatttgc actgcaagct gcacttgagt tggctccaga ttctcgtacc 2072761 ctactttctt agcaatctct aaatattcat cagggtcaga tacaccgtca ttaagttttt 2072821 tctttaattc cttgatttca cgttcctttg cttcttcttt cttcacactt aagtaagctt 2072881 cagaatgctt ttcaatatcg ccttttttct tatgtatgtc actttctctg tacgctttag 2072941 cgttatagtg aattggtgta gcgttttttc ctttgcctgt tgattcctgc agctttttaa 2073001 agtcttgctg aataaattgt tcgtttggtt ctgtttcagc gtattctgtt tttaaatcct 2073061 catcaagctt gtttagctta tcgattgttt tttcacgttt gtcatctgca gaagaaagtt 2073121 tgtctttgaa gtcttctgtt gagaatattt caaggggaag gatatcattg atgttgttta 2073181 atatgtcttt cattgctttt ttctgttcag acataatgga ttttgatttt gcataagcgt 2073241 tagccaactc gtgttctaga aaggattctt ctatgtaagc atcagacatc ttcgcatctt 2073301 caagtgttgc agacatgctg cttaagaaag caatcttcat atcgataaga tcaatccatt 2073361 ggtctgttac gccgacatga ccatgataaa atgctttaat gttgtcagca cccttgcctg 2073421 aaaattcact gtcatctagg ttagctactt ccttaaacgc ttttttgagc ttcaccattt 2073481 gcgaccttag ttccttatac tctttggttc ttttatccgc ttcaaagagt aatgaatcag 2073541 cctcaaatac cttcatatca ttctccttcc tagactactt ctatgtaaat tttaccacag 2073601 taatctaatt gaataacaga aaaagacagc caaaatgact gtcttataca tcacacacta 2073661 tcttgttcta taataatttt ctgcggtata gtagcgccaa tcccaaaaag gttccccatt 2073721 ggccaatata taccggtcta aaaatttttc aaagtttaaa tttaatggat tatattctaa 2073781 accactttca aatatataga gatagttggg atcaccttgg ttcactttat ctttatcgat 2073841 cattaaatgg cattcttcca ataagtagcc aattggaata ccattgatat cttcaaacaa 2073901 atcttcatat tttaactcct cttcaatctc ttcaaggcta aatagctgaa gtcctccacc 2073961 tatattctcc ccatcagaaa gaatctcaaa aattttcgca ccgttatgta gtgtcatgaa 2074021 cttctgataa tcctgtggaa gggtaagctg gtgtttagcc tcaaagcttt gaatgtcatt 2074081 cagggttgct ttgtcctgtg aaaaagtaac aaggaactcc atgatatcac cttctgaaca 2074141 aaacaattta atggctcctt tttcgtctaa aagacttttc aagccattta cagtcttatg 2074201 aacaaagtta gtcacataca tcaccccttt atttcctttt aacaataacc tttcaaattc 2074261 caaaagatgt gaacagatcg tgataggtgc tcttttcagt gaatataatg caataaattc 2074321 taaaaagagg tgcctccaaa aattgaattc tctaatgaat gatgacatgg taaagatcat 2074381 tagaaatggc cttagcgcat cgcagcatcc aaagcacatt cttgttatag gagctggatt 2074441 gtccgggctt gtatcagcat ctttgttgaa aaatgccggt cacagagtaa cgattctcga 2074501 agcgagcggc agagcgggcg gccgtgtctg cactttgaga tctcccttta gtgatgattt 2074561 gtatttcaac gctggcccga tgcgcatacc gaataaccat tcgttaacct tagaatatat 2074621 caaaaaattc aaattgccaa caaatgtatt tatcaacaga accccgatgg acatcattta 2074681 tgcaaatgga atcaaaacac gtctccaagt ttttgaacga gctcctggaa tattgagata 2074741 tccagttgca ccaaatgaac aagggaaaac gtctgaagag ctgatgcttt ctttactgca 2074801 gcctattcta aattttatca atcaaaatcc agcaagaaat tggcggattg tcgaagaaca 2074861 atacaaaaat cattcgttaa gctctttttt aaacacgtat ttttcatatg gcgcgatcga 2074921 tatgatcggt gtacttttgg atatggaagc gtatatgggg atgtcccttg ttgaagtatt 2074981 gcgggaatct atcttttttt catcccccgc tcacttctat gagataactg gcggtatgga 2075041 tctgctgcct cacgcgtttc ttcctcaatt aaaaacaaac attctatacc atcaaaaaat 2075101 gatgaaaatg tctcagggtg aaaatcgtgt tacgatccat tgtcagcatc aacaaacggc 2075161 agaattcaca tcattcacag ctgatctcgc tattgtaacc attccttttt caacattgcg 2075221 atttgtaaaa gtcgaaccat accattcatt ctcttactat aaacggaggg ccatccgtga 2075281 gctaaactat atcagtgcaa caaaaatcgg catagagttt aaaagccgat tttgggaaaa 2075341 agccggtcag cacggcggca aatctattac tgatcttccg attcgttttt catattatcc 2075401 aagcagaaat attggagcaa atggacatgc tgtcattctg gccagctata catgggccga 2075461 tgaggcactg atatgggaca gtctttcaga aggagagcga atccagtata ctttactgaa 2075521 tttatctgaa atctatggtg atattgtgtg gtctgaattt gtgtctggca cttcttttag 2075581 ctggagccag tacccgtatt ctgcgggagg ttttacagct ttcgaaccag gacaagaatt 2075641 agagctgtat ccctatattc ctgtccctga gggcagagtt catttcgccg gagaacacgc 2075701 ctcactcact catgcgtgga tgcaaggcgc gattgaatct ggaatacgtg ttgcttatga 2075761 ggtcaatcgc ttaccttaga tcatgctcac atcttgttaa aactggttga tataaaaaga 2075821 agtgaagaat ttatactcct ttgtttaaaa gattaattca aatatgggat gtctcaacat 2075881 tcggttcttt attatcttta tacacgtttt gaatgcggac ctcccttttc ttccataatc 2075941 attaataaat acccaaccat aggaaacgtt ttaattaacc atcgggcgaa ctttctttca 2076001 ctgtataacg attcttaatg ttgcttttta tcctttactt gtcctctctt tttttcattg 2076061 acttacattt cttgaaaacc agtataaatc ctaaaggaat tttgtaacaa atacagaatt 2076121 ggaaagagaa gcgccaaaag aaatgctaac tccttatctc aaagacaaaa ctgcgcttat 2076181 attaaaagaa agaggtgtct ttagaatggt tcattttaaa aactgccctg atccttctct 2076241 aaacgccaat tctcagtctc accccgaatt ttcatccgaa ttagaacata ttaagacaag 2076301 aatgcaaaac tttattaagc actcggttac agaccaaaat atcgaagtta ctgacgcaag 2076361 ggtgacggcc gaaggagagg tcacctctct tttaaaagaa cgtctcgaca aggaatatta 2076421 taggctttta tctaaaatca cccgggaagt aaatgtggct gacttcggcg ctgttccaga 2076481 tggaagagac aatactgaag cttttcgaaa agcaatcggg aatggccgag tcaaagtaca 2076541 tgttccagcg ggagaatacc tcgttcaagg gattaaactt ccatcttgga caacaattgt 2076601 tggacaaggt aaagggatca cagtgattaa attgcatgaa gacactccag cgcatgaatg 2076661 ggtgattaca aatgatgatt atcaaaatgg aaatcgcaat atttttgtcc aaggaatgtc 2076721 attagactgg aatccaagta gacaatgcgg tgtgagaaat ccagggggac agttctccag 2076781 ttgtttaact tttgctaagg ttgaatatgg gtggatcaaa gatgtggaag cgattaacgc 2076841 aggtcttcat ggtattgata ttacatcgcc aacgtatgac catttgcctg ataccgattg 2076901 gacaaaagac ggatcaagat atatttggat cgataactgt gtgacatatg gttcaggaga 2076961 cgacggcatt accacccatt atagcgaata catctttatt tcaaactgcc attcaggaaa 2077021 tccgcgggga acagaatttg ctgaaggtgt ttcaaactcc aacggaatag aaattgacga 2077081 cggctctagg catgtgtggc ttttgaataa ctttacaagc ggcaacatcc gcggagttga 2077141 agtaaaagcc catgaactgt ggccagcctc tcaaaacgtc catatcatag gccatatttc 2077201 ttatcgcgat gttcgtgcat ttgatcttcg tcatattggt caccatcaaa ttacagatcc 2077261 tgaaagcaca acagcatacg atgtcacact cattgattgt tcagcagttg aaccagtttt 2077321 caactcgctt tacgatgctg tgaccccaag agcgctggtt atttcggcat ataaaaacgt 2077381 taatgtaagc ggattcacag cgattggtga tccagactat gattataaag aaaaccctgt 2077441 cgtagccttg caatatcgca gccaaaatat aaccattaat ggtattaaaa ttcgcggttt 2077501 taaaaaagcc ggtgttgata ttaatttatc aggcggatca aataaaactg attatattaa 2077561 aatttcaaat tttgatattt ataaatctgc tccaaaagga atttcaatcg gtggaggcct 2077621 ctacaatgtc aatattctaa atggaacgat gattactgac aatgggacag ttgcaattca 2077681 gtcccccaat aatcaggcca caattctcgg tgtacaatca gaaggttata gtgtggcagc 2077741 ctcaatcaaa ggccaaacat accaacaagt tccaatcaat ttgaaaggag gcatacagct 2077801 tgcaacgacc tctggctttg ccgttaacca aacaagcgca gttatagcag gtaccggcga 2077861 cattacggcc cgcggagaaa gaaatgcggt cattagctct tctggaggct ccagtactga 2077921 aggctctcgc gcattaatcg cttcttcaaa taacgcacat attagaggaa accaagcgtc 2077981 aagaacaata ctgtcttctg aaaatattat acttgaggaa ccatacaccg tggcaggagg 2078041 tcatcaatca ataaagtggc ttcttgactc tgttcgggga aacgggacgt ttgccggtgc 2078101 aatcagttct tctttaggtg gatatggaga gtattttgag agttcaactg gacagttaat 2078161 ccatactggt acaatcgtga ctttaagagg tgaaaaaatt gtgcccgcga atgttggaga 2078221 ttatatgctt ggcgttattt cagaaacttc agctttcatt tcaggagcct ccagtttcgt 2078281 ctggcagggc cgttatttga caaatgagtt cggcggattt atttatgaaa cggtgactga 2078341 tgaggaaagc ggtgaactca tacgtgttcc caaacaaaat ccagactacg atacagcgct 2078401 ggaggcaaat tatcattcac gggcagcaag agacgaatgg cacgttgtag ggttggttgg 2078461 ccaacattat gtgcgtattg acgaaactgt caatcaagga gattatctta cggcacataa 2078521 tggaatagga acaaaagcca ctgaaggaag ctggaaagta atgaaaataa cctctgctta 2078581 cacatcagaa aaagggtatg gtatcgctct aaccgtcatc aaatagtgga tacgccgacc 2078641 agttcaatat atgtttatcc aaataattag atctcttttc taggttcttt attccttgta 2078701 tgttattatc aattttcaat atctaccaaa atacccctaa tatactatcg taattaactt 2078761 atattataat caaaaaaatt ttgacagctg ttccttctcg ttattcatga aagttgctat 2078821 tgaaatgagt aaatggatat catattagac ttctatagca aatacaccat atatatcctt 2078881 taagtattta caaattgaaa atgtttcatg aggcttatta aaagtattgt tcttttatca 2078941 tctgtaagtc gatacaaact gcattaagat cacacctaaa tctcactgag ttttttctta 2079001 caaataaaat gaaaaccctt tccattctaa attcatttca ccgttactaa aagtaatcct 2079061 tgcattcctt cgccctccat gctatattca tatagcgatg agctgaattg tgtaagccga 2079121 tgtacatgcc tttacggcac acacgaatgt ggcgtgtggt gcatcgcctc aatacgcaaa 2079181 gacgtttgcc ttaggcaaac gtcttttttt gcgttatccg atttttgtgc cgtttgggac 2079241 aggctgatcc ggctgcaaaa ggacgacgtc gccctggccg ggtatgccgc cgaggaccaa 2079301 gacttccgat ttaaatccgg cgatccggcg gggcggaaag ttcacgactg ctatgacttg 2079361 cttgttgatg agaccttccg gcttgtaacg cttcgtgatt tgtgcgctcg attgttttat 2079421 gccgatttca gtcccaaaat ctatcacaag cttgattgcc ggtactcttg cttcaggaaa 2079481 ttcttccgct tttacaattg ttcccgttct gatatccaat ttctcaaagt catcaataac 2079541 tgccatatca ataactcctt tttctcctat tgtaaaggag atatacaata ttcttttaac 2079601 taaagagcca tcatttttta tccgaatata aggtgtttcg atacaggcgg ggcggcattc 2079661 ctgtgctttt cgtgaaccat cttgtaaaag aagaaaggtt ttgaaagccc agcgcctcgc 2079721 tcacgacggt aagagtttca tttctctcca tcagcattct ttttgcttcc tcaaggcgaa 2079781 ggtcggcaat atagttctgc ggggacttcc ctgtctgttt tttgaaccag cttgaatagt 2079841 aagctgggtg ataatgctcg atttctgcca gcttcttaat cgtcagccgc tcaaataaat 2079901 ggctgtgaat gtatgcaatt gaggcatagc tatgggattg aagcttttct tttatgtatt 2079961 gtactagcat atgaagcgag ttggctgttc cggcctttgc ttcctctgtc agcaagtacc 2080021 tgatcgaaga ccagaaagga tcgagggcag cttcaattcc tgatcctgca cgatactcat 2080081 caattttcat tgcatgaagc ggaacatcca gtacaagaca ttcatttctt ccgatagaac 2080141 ggaagcgatg ctcgcactgc ggcggaatat ataaaaaatg atccggattt aatttcacct 2080201 ggcgcccctc agtctcaaga tcaatactcc cttcaagcgg aaaaagaaat tggctgtacg 2080261 cgtgcttatg tgaatgatat agccgtgtgt atgtccgttt ttcgcaaatt atctcttgaa 2080321 gcgagtccat tagcaaaccc cttcctttgg tcatctttta atccggtaat ggtgttccga 2080381 tataggcgaa aagccgattt ttccatataa agaaactgcc gccagatttt ctttcatcac 2080441 ttgtaaaaac atgcgttccg ctccgttgtt ttttgcccat tcagtcaaca ccctgatcac 2080501 ttgggttcct gccccttttc ctctgtgctc ctcagctaca acgatattac taagtccgcc 2080561 ataaccatca atgacagaaa ccgtgccaag cgctgtcagg ctttctttgt catacatctt 2080621 gaaaaaagtt ttacacggcg gcatgcgttc gaatatgtgt ttgtaacctt tgtgacgctc 2080681 gggtgaaaac ccttctaatt gaataaattc atctatccaa acagatgatg gctcttgttc 2080741 ccacttgtat gtaaatcggc tgttgtcatt tgttcggctc ataattgacc ggcacaacgc 2080801 tgtcatctgg aagcactcgt ctaccttttc ataacggctg tctgccaatg cgtcatcaag 2080861 ccctttcggt gatgcgttgc taatatgaaa acaaacaggt aagcctaaac tttgataaaa 2080921 aagttcggcc tctagctgaa aatccccttc aggcatatcc gcagacgtcc atacgctatt 2080981 tgcccttttg gttacgccaa aattcgctct gagaagccat ttccctatgc ttttttgaaa 2081041 ataagccggc catgaagctg ccgctaatcg ttcaatcttg cgaatgtcat ccattgcata 2081101 atgcctctcc cctatgtata ctcccttgat attatacaat attcagaaat ataagacatc 2081161 catttatttg tttacataat atttttattg tttattaata atcctgacaa aaatgtccga 2081221 attgaaaatg acaggctttc taaaatgtcc tcctcacgtt caaatgcttc ttttgcgatt 2081281 aaaacagtaa agccatgcag cagacttctg agcccccttg tcgcatgaat ggcagtcttt 2081341 tcacttgcat agccgttttc aatgagcagc ttcgtcacaa gacagacaat ttggtcagag 2081401 acgatttccg tccgtttgtc gtgaacctta agaagagccg cttcataata tccgggattt 2081461 tcaattgcaa aatcaacata tgcatgagct aaagaaagca tcgcggaatc tccctttcgt 2081521 tcggttacgg agtccgccat ttgatcaaaa agctttgtca gtcctctgac agcaagttct 2081581 gctctgatcg cttgcagccc gttgatatgg ttatacaatg acggggggcg aacattcatt 2081641 tttttagaaa gtgcagcaag tgagacacca tttacccctt cctgatcggc aatctctgct 2081701 gcagcgtcta caatcatttt ttgggtcaaa cctattctcg gtgacatgct catcatcctt 2081761 tctttgcttt ttggatcgcc tgtctcatcc gctctgaagg tgatcgcagg aattttccat 2081821 gtccgacagc gagacaggaa ggcgccttat cggcgagcaa ttgtgcactt ttgatggcct 2081881 cctccttatt ccatgtggcg aaagcgggaa aaggaaacgc ccattttatc tgacctgata 2081941 cagcgattcc tccgcgcaac tgaaacgcat ctcctgctat taaagtgccg tttcttgtat 2082001 caagaaatga catgctgccc ggtgtatggc ccggtgttgg aatggcaagc agagaaccaa 2082061 ttgtttcacc gcccgtcagc agttggtgag gctttgtttg tatgtgtttc ggaatacctc 2082121 cttttatagg cgtctgcggc tcatcttgcc gcaaagatgt gtcaccttgg agcaagaatg 2082181 aatcccgttc cgagatcatg acctttgcat gcggaaatgt ttgtgccaat gtatccagtg 2082241 atccgacatg gtccccatgt gcatgagtca gtaaaatatg ctgaagcggt tttccaagct 2082301 gattcacagc ttgaataatc cctttatagc tgcctggcag tgcggcatca ataagggtga 2082361 cttcgttttc ttcctctact aaatagcaat taaccggaaa caatgctgga aaaaaagtca 2082421 gctgccaaac cgtttggtac tgagtaattc tcatcttttt attcctccta acaaaaacta 2082481 atggtgttag ttttattatt aactaacacc attagttttt caagagttta ttattttttt 2082541 atcgctacat aaatgttaac ttgtgctcgc tgtggcactg cggcattttg atcatacatc 2082601 tcaaagtcac ctgtaaacgt gcgcagatgc cgcttatccc aagtccaaat ttccttccac 2082661 gtttcaagca caatctcttc aataggaccg attctggaag tgaaaacggc gtaagcggaa 2082721 gccggcaaat caatattttc atatggtccc ggaagaatgt cgtcgtattc ctgaaacgtt 2082781 ccgactgaaa acgtataaaa cccattcgtc tcttgttcat aattcgaata taaggcaata 2082841 atgctcttgt ctttttcagc ctgtgataaa agagcgctca tatcctgctt ccataattga 2082901 tcccacagtg ccggaatcct cctttcttcc gtcatttcca gtgcgttgct tgtccgttgt 2082961 gatagtccgg caaatcgttt caggtctaag tgtgttatat gtgaaaagcc catacgatct 2083021 cctccttttt ttaagattat agacaaagaa acctgacagc agtgtgtcag gtttcatata 2083081 ttttttgcat gtgatgaatg gtttctttta ctttatccct tatatgaaga ggctgcagaa 2083141 cctcaatatc ctttccgaac tggagcaaaa aaccgatcag ccattgatct tctggaagtg 2083201 aaatcaccgc ctggcagatt tcatcttcct cacaacagtg aaggacatca tatccgaacc 2083261 attcacctat acgctgacgt gctgacggct gaacaagaat aaccaattca gttaaacggt 2083321 ccttttggta ccaactctta tcccatggca aagtgtccag ctgaatgtct tttctgataa 2083381 atgtctgatg taagatggcc agatctttca tccggttcag tttaaaaaag cgaaaatcat 2083441 ttcttaccag gcagtaggca tataaatacc agtgccccgc cttgcaaacc aatgtataag 2083501 gttcagtttc ccgaagtagt gtttccccgc ttgcgcttgt atatgtaaaa gatatcgtta 2083561 acaaccgatc gatggcagcg ctgattttct cgcgcagcgt cttttgatcc tcagtatggc 2083621 cccaagccgt catgtcaata aaccattttt ctgtttggtg cttaaatgct tgagtagatt 2083681 gctcaggtat aaggtgtttg attttttgat aggctgtgct gtgagaaacg ggttcataca 2083741 tagatgaaac gctttgcaaa gcggaagcaa ttgcaaacaa ttcctcctcc ttcagccact 2083801 ctctttcaag ccgatacgtt tccatgatgc caattccgcc cccggaaccc tgtgaggtca 2083861 caatcggaat accagcccta ttgatcgtct caatatcacg gtaaattgtt ctgacagata 2083921 cttcaaacag ctcagcaagc tctgcagcct gcacttgttt tttgctgatc aataacacaa 2083981 ccatcgctaa caaacgttcc agtttcattc tgcgcacctt ttcttcttgt attttccaac 2084041 aaaacaatca taacattttg ataaagcttg ggcatatcta ttatgcggcg gaatacacct 2084101 cgcatatgct atgaaaacag gggtttcccc ttcttttttg tgttcagtat ttatttcagc 2084161 tactatttcc gaccggataa gcatacactt ctcaacggag gggatttcac atcatgcatc 2084221 ttacacttca gagcgtttat cctgccataa tcatcatctt ttttctgtat aaaaaaatta 2084281 aaaggtccat cggataccag ccgctgaagc cccgctggct gttcacccgt atcattcttt 2084341 tctcgctgtt tgcttttgga ctttcaatct tcagcgccat tcaccctttt ttatatggat 2084401 atctcatttt gggcattctt ggcggatggc tccttgtctt tttcgctaag aaaaacatct 2084461 cttttgaaaa acgcagagga aagatctatt ttcggactca tatttgggta gaggtgattc 2084521 tcttaacttt atttctatca agatttctgt atcgagtgac ggagctttat cttacctcac 2084581 ctgatctaaa ccgccttgga tcatacagtc agtcaatcgg aacggaccct ctgacaattg 2084641 gcgtctgttt tctgatagcc gtttattata tcggtttttc ttcttttatc atcaagctca 2084701 gcagaaacga acttgaacag cacgaataca ataaagaaaa agacatcctt gcccgctaac 2084761 agcgagttaa gcaaggatgt ctttttcaat catgctgtgt atgatggatc atttgctgaa 2084821 gaacatctaa aacatgttca tcctccggag agtaataaat cgatgttcct tctctgcgcg 2084881 atttgacaag ccggagattt tttaaaaatc taagctggtg ggacacagtg gattgcagta 2084941 aattcagctt ttctgcaatt ccgtttactg catgctcacc ttgggacaat aaatggagaa 2085001 ttctgattcg ggtaggatct gaaagcgctt tgaatgtttg cgcgactaga aacagcgtct 2085061 cctcgtccag atcagcagcc gattgttccg tttctctaaa ttcagtcata tgtatcacct 2085121 ttctttattc atagttttat cttataacaa atgcgcttga gtgcaaacca gcctgcttgt 2085181 attccatttc aatctcatag tttaaattta tgtttcaaat caggttttta cttggtctga 2085241 tataccctct tatgtcataa taaaaaaggt catactgctc caaacattga gggtgaaaca 2085301 cagtgaagaa aaagagaaaa ggctgtttcg ctgctgcggg ttttatgatg atttttgtct 2085361 ttgtcatcgc ctctttttta ttggtcctgc tttttttcaa ccgggattta atcaaaaaac 2085421 ttccgatcga tacgaaaacg attgttttgg aacgtttaac cgattacaaa cccttggtgg 2085481 aagaagagct tgaaagccaa ggactctcta attatacatc actcatatta ggcatgatgt 2085541 atcaggagtc aaaaggaaaa ggcaatgatc ccatgcagtc ctctgaatct ctggggttaa 2085601 aacgcaatga gataacagac cctcaactca gtgttaaaca aggcatcaag caatttaccc 2085661 tcatgtacaa gaccggtaag gaaaaaggcg tggatttgga taccattatt caaagctaca 2085721 acatgggggc aggttacatt gattttgtag ctgaacatgg aggaacgcat actgaggaat 2085781 tggcaaaaca atactccgag cagcaagtca aaaaaaatcc tgatctgtat acttgcgggg 2085841 gaaatgcgaa aaatttccgc tatccgtatt gctacggtga ttatacgtat gcagaaaaag 2085901 taaaagaaaa aacaaaaact gttgaagaat ctttgcaggt tgcaacactt gaaaccatgg 2085961 aatccaaggc tcatgaataa gagtctatca atttactgac aaaagcccaa aaatgaattt 2086021 gggcttttgc catgtttaca cgtaaaaaaa gccatactga gtatggcttt taataatacg 2086081 gtgaaatcat caaatataca ataacgcctg taaggcttac atacagccat agaggcattg 2086141 tccatctcgc aattttttta tggcgctcca cctgcatgct gaagcctctg atcagcgtaa 2086201 acagcgcaag cggcacaata attgcagaaa ggcagatatg tgtaattaaa ataaagaaat 2086261 aaatcgggcg cataatacct tctccgccat agagcgtgtt ttccgcaatc gagtggtacg 2086321 tcacatagca aatcaaaaat agtaatgttg ttgtgaacgc agccaaaata aagcgtttgt 2086381 gagctttgat atttttctgt ttaatcataa tcagcgcggc caataagaag ataaacgtaa 2086441 agctattgaa tatcgcattc agcattggca aaatgtgaat attcgcatgg ctgaactgat 2086501 ctaatttagg cataaaaaac agcactgcga ttaaaccgtt aatcagaact gtcagcgtaa 2086561 ggacaatccc cgtgtaattt ttcggtttat tttctgtttg gttcatttgg tgacctctcc 2086621 taatttgtac tggctatcca aatcgtatgc aaattcaaag aagatgtcaa cggtttcgat 2086681 tgcttcgtca gaaattagac acacttcaaa ggccggaggc tattagcccc ggcctgttag 2086741 gtttacgcct cttttatcaa atgttcaatg accttatgtt cattttcatt cagcaggttc 2086801 ttttgaattt tcgaatgaat gggtttattc atatgctgat ccaagatatc ggccgtttct 2086861 ttatccccgg caataaccat tcgttcccat cttttcgcgg cagctttttg atcaaggctg 2086921 gcagccagcc gcttatacag tctcgattgg ttctctgtta catgttccct catccggttc 2086981 tcttcaaatg gtggcgcttt gtctacagcg gaatggctat tcttccaaga ctcattgatc 2087041 atatcatact cataacgctc caccgcctca atttttccta aaacagtttc aataattttc 2087101 acttcatgct gctgagttaa aataaacgcc gtacttgggt atgtctggcg caaacccttt 2087161 agctgatcca ggacagctgt ttcttcccag taaaatcttg tatctacagg gacttgaagc 2087221 ttaataggtt cccatatgcc gctgtcggaa acaaaaaaca cgagactgcg gggcatgtct 2087281 tttcccattg cattcaagta ttgattcatt ttagccctga ttccatccag acacttttcc 2087341 tcctctggat cactagctgc caaatactct tttaatcggc tgaatcctga ctttagggca 2087401 atcttccatt ctcccccctg ctgctctgga tctctcatgt ctgtattgag atacagagag 2087461 agaattttat ccggcggttc caattggaca tactgtaatt tgttaatcaa tgaatcaatc 2087521 gccattccga ttcctccttt ttcacaggtt agttttcttt ttcctctctt aaaaacgatc 2087581 aaacctgact ttccgctaat ttctagtaat aatggaattg ttgtttacaa tacgcctctc 2087641 ttctaataca attggtaact gtgtttctaa gctgtttttt gaaaggagtt tgatcttgtt 2087701 tactgttaaa gaaaaaaatc gtcaagagct tgaggaagaa ctaaatgatt tagaatttca 2087761 aatttatcgc atgcaggaga atatgaagga tttatctaaa gatgccaaag tgcttggtat 2087821 tgatcaatcg aaacatgatg agtggatgat tgtttcctcg attgatgatg gccaaacatg 2087881 caaaattatg ctaactgatt gtaaaacggc ataccgagga aaaggctgtt tttcacttgt 2087941 agcgtcttac aaggacgatg ccattcatat aggggatata aaaggccctc cgaatcacgg 2088001 gtttggctcc atttgcatga aatatttaaa agatattgca agagaccata atataccgaa 2088061 agtcaccgga gacatcgcca aacgggattg gaatcatgta gaccggctga ttcactttta 2088121 tgaaaaacat cacttcaaag tatgtatcga tcatgatacc caatccggca gcattaagtg 2088181 ggttgatttg taaaaaagtc tggaagaaag agccaagata tgctgtaatg gtataaaacc 2088241 attgatggag ggttctatgt acgcctcaaa actgaaaaag ggagacgaaa tccggatcgt 2088301 gtctcccgcg accagcatgt ctatattatc aaatgaagca aaaatccaag caaaaacggc 2088361 gttagaacgc ttaggttatc gggtaaccat cgctgaacac gcaaatgaat gtaacgaatt 2088421 tgattcatcc tctatcgagt caagagtcca tgatctgcac gctgcctttt ttgatccagg 2088481 cgtcaaagcg attttaacga cactcggagg gtttaattca aatcagctgc tgcgttatct 2088541 tgattacgag aaaatcaaac gacatccaaa aattctgtgc ggttattccg atataaccgc 2088601 tctttgcaac gctatttatc aaaaaacggg tcttgttacg tattcaggtc cccacttctc 2088661 aacatttgca atgaaaaaag gactcgatta tacagaggag tattttcttt cttgctgcgc 2088721 ttcagacgat ccgtttgaaa ttcacccctc aagtgagtgg agcgatgatc gctggttttt 2088781 ggatcaagaa aacaggcgtt tttatcctaa taacggccct gttgtaatcc aagaaggtta 2088841 tgcggaaggt actttaattg gcggaaactt atgcacgctt aatttgctgc agggaacgga 2088901 gtattttccc gaaacagaac atactatttt attgattgaa gatgattata tgtcagacat 2088961 ccatatgttt gaccgcgatc tgcaatcact catccacctc cccgcttttt cacatgtaaa 2089021 ggcgattttg atcggcagat ttcagaaagc atcaaacgta tcaatagatc ttgtaaaagc 2089081 catgatcgaa acaaaaaaag aattatccgg catcccgatc atcgcaaata taaatgccgg 2089141 acatacctcg ccaattgcca cgttccctat aggaggaaca tgcaggattg aagctatttc 2089201 gggtacatca cgaatatgga ttgataaaca ttaatcagct tgtaaatttt tttacaagct 2089261 tttttagcgc aatcggctat gcatgccgca cgagacatga caaatgtcat ataggaggca 2089321 tgatgtgtgc tactacaaaa gacttctctc attagcgtat actgaaccga gacacacaat 2089381 gagaggatac ttactatgac tgaacaaacc attgcacata aacaaaaaca gctgacaaag 2089441 caagtcgctg catttgctca gcctgaaaca aaaaacagcc tgattcagct tttaaacacg 2089501 tttatcccat tcttcggcct atggtttctt gcttatctca gcctcgatgt ctcctatctt 2089561 cttacgttag cattaacggt gattgccgca ggttttctga caagaatttt tatcatcttc 2089621 catgactgct gccatcaatc ttttttcaaa caaaaacgct ataaccacat tctcggtttt 2089681 ctgacaggtg tcctgacttt attcccgtat cttcaatggc agcacagcca ttcgattcat 2089741 catgcaacta gcagcaatct ggataaacgc ggaacaggag acatctggat gttaacagta 2089801 aacgaatata aagctgcatc cagacgaaca aagcttgcat acagacttta tagaaacccg 2089861 tttatcatgt ttattctcgg accgatttat gtttttctga tcacgaaccg ttttaacaaa 2089921 aaaggcgcaa gacgcaagga acgtgtaaac acatacctta cgaatctggc aattgtcgcg 2089981 ttggctgccg cttgctgtct gatctttggc tggcaatcgt ttttactggt gcaaggcccg 2090041 atatttctga tttcaggttc aatcggtgtt tggctgtttt atgtgcagca tacctttgaa 2090101 gattcttatt ttgaagcgga tgaaaactgg agctacgttc aggctgctgt tgaaggcagc 2090161 tcattttata aactcccgaa actgcttcaa tggctaacag gcaatattgg ttaccaccac 2090221 gttcatcatt tgagtccaaa ggtgcctaac tataagcttg aagttgctca tgaacatcac 2090281 gaaccattaa aaaacgtacc gacaatcacc ttaaaaacaa gcctgcaatc acttgcgttc 2090341 cgtctatggg atgaagataa caaacagttt gtgtcatttc gggctataaa acatatacct 2090401 gtaagccttc cgcctgattc accagaaaaa cagaagctgc ggaagaatgc ctgatgataa 2090461 aggaggtctt ctaatatact agaaggcttc ctttttattg ttggagggtg cattctggct 2090521 ttcacaatga taaagttaca agtaagatga aaagctgaaa atgaggtaag atcatgatta 2090581 aaaatcattt tacatttcaa aaactaaacg ggattacgcc ctatatatgg acgatatttt 2090641 tcatcctccc cttctacttt atatggaaat catcatctac atttgttatt attgtcggca 2090701 tcattttgac gcttttattt ttttcggtat atcgatttgc ttttgtctca aaaggctgga 2090761 ccatttattt gtggggattt ttattaattg gcatttcaac cgcctccatt actctgttca 2090821 gttatattta ttttgctttc tttattgctt attttattgg aaacattaag gaacgcgtcc 2090881 cttttcatat tttatattat gtccatttaa taagcgcggc cgtcgcagcc aatttcagtc 2090941 tcgtattaaa aaaggaattc tttctgacac aaattccttt tgtcgttatt accctcatca 2091001 gcgcaatttt attgcccttc agtataaaaa gccgcaagga gcgcgaacga cttgaagaaa 2091061 agctcgagga tgcaaatgaa cggattgcag aactggtaaa attagaagaa cgtcagcgaa 2091121 ttgcccgcga tctccatgat acgcttgggc aaaagctttc tcttattggt ttaaaaagcg 2091181 acttagcaag aaaattgata tacaaagatc ccgaacaagc agctcgtgaa ctgaaaagtg 2091241 ttcagcaaac agcgcgaact tctttaaatg aagtaagaaa aatcgtttcc tctatgaagg 2091301 gcatccggct caaggatgaa ttgatcaaca tcaaacaaat tctcgaagca gctgacatta 2091361 tgtttatcta tgaagaagag aaatggcccg agaatatctc attgctgaat gaaaacattt 2091421 tgagcatgtg cttaaaggaa gctgtcacaa atgtcgtcaa acacagccag gctaaaactt 2091481 gccgagttga cattcagcag ctctggaagg aagttgtgat tacagtgtct gacgatggaa 2091541 cattcaaagg agaagaaaat tccttttcaa aaggacatgg cttactcggg atgagagaac 2091601 ggcttgagtt tgcaaacgga agccttcaca tcgataccga aaacgggacc aagcttacca 2091661 tggcaattcc taataattca aaataaacat aaaggatggc ttatatgatt agtatattta 2091721 ttgcagaaga tcagcaaatg ctgctgggcg ctttaggatc acttctaaac ctcgaagacg 2091781 atatggaagt cgtaggcaaa ggtacaaccg gccaagatgc tgttgatttt gtcaaaaaac 2091841 gccagcctga tgtatgtatt atggacattg aaatgcccgg aaaaacaggg cttgaagctg 2091901 ctgaggagct aaaagataca ggctgcaaaa ttatcatctt aaccaccttc gccagacccg 2091961 gttactttca gagagctatt aaagctggcg ttaaaggcta tttgttaaaa gacagtccga 2092021 gtgaagagct ggccaacgcc atccgtagcg tcatgaacgg aaaacgcatc tatgcacctg 2092081 aactgatgga ggacttatac agcgaagcta accctcttac agatagagaa aaagaagtgc 2092141 tcgaacttgt ggctgacggt aaaaacacaa aagaaatcgc tcaggaactc agcatcaaaa 2092201 gcgggacggt gcggaattat atctcaatga ttctagaaaa gcttgaagtg aaaaatcgaa 2092261 ttgaagccat tacccggtca aaagaaaaag gctggtttaa ataaaaaagg atcttggcat 2092321 ctgccaggat cctttttgtt aacctgaaat tcccgtttga gaacctcgtc gcaaccagaa 2092381 ttaaattgat ccatatcctc gctcctacgc ccgctgaacg attgtttggt taacagccca 2092441 ataaaagact ggattgaatg atatccctgt taaaatggtc ggccattgca catcagcaga 2092501 atttctgata ttgattatat tgtattttca gtatgacaaa gttgtgccac ttcgctcccg 2092561 aagctgccat gcccaactgc aagagcctaa tatcacaata aaaaaccgtc tgaaatcaat 2092621 ccgattccgt aaatggtatc tgctacatcc aactgcttat tatctgccaa aaacaccagc 2092681 tcgtttcgct gatcaaagat agtaacaacc agctataaat gtcatgatgc cgaatgtctc 2092741 tgtaatgtgg aatcaatctt ttaacccgag agcccctgaa tcgcacataa agaaaaacgg 2092801 gaccactttc ttttatcagc atatgatata aacagctcta agcagaacaa aaaaagacac 2092861 aagccaaaag cttatgtctt ttatcacaat ctatattatt agtttaagac tttaacactt 2092921 acagttttga cgccccaatt agaagcatca cttttacttg gtacaaatac gtcgatttta 2092981 tttcctttaa tagcgccgcc agtgtctgct gctgttgctt ccccgtagcc ttcaacatag 2093041 actttagaac ctagcggaat tacattagga tcaaccgcaa taactttcgc gttcgggttc 2093101 ttatttaagt caatgcctgt agctgtaacg ccggaaatgc cgccgtcgtt agcagtgtaa 2093161 gcagtagcag taactgttag ttcttttgaa gcttcttgat tatttgtatt tgattgaaca 2093221 gccttctcct ctgtgttaac agaagtttct gcctcagcct ttgtttcttg tttaggttgc 2093281 tgttgtacag cttcttgttt aggttgctct ttttgcacag cctcttgttt tggcgcagct 2093341 tgaggtgcgt ttgtttgcgc attctcagta gctgtgtttg ctgctgttgc ctgacctttt 2093401 actgaaagag ttgatccagc atagatcatg tcagagctta agttattcca aactttcagg 2093461 ttgttgactg tcgtgccgaa tttttgagca atcttagaaa gcgtatctcc cgctttaatt 2093521 gtatattgcc cagtcgtggt tgtttcttct gaagaaatgg tcagtttttc tcctgcaatg 2093581 attttatcag aagttaactt gttccattct tttaagtcct ttaggttcac tccatttttc 2093641 tgagagattc cccagagcgt atcacccttt tgcaccgtaa tttcttttgc agaagcgtga 2093701 gctccgaatg cagttgttga aagtgcagca actgccacaa aggacataat cgtcttcttc 2093761 ataagtaaat cctcccttgt tagcttttta ttggcggcta acaggtgata tcgtaacaca 2093821 cgtaaatgtc aaatcaataa caaaaagata tgatttagat tacagttcct ttacatgaag 2093881 gatttctctc tgatggaaag acttgctgaa cccttgatat aataggcttc gcaggtcttt 2093941 ttattttgag gcgaaacaga gaaaataaaa tgtgtttttt atagaaaaaa agattgtttt 2094001 tctgtttttt tagtctgtca tccttgcata agcctgtatt tcttgtaaaa aaagccggcc 2094061 gtattttgct cttttttgtt ctccgactcc ttttatagac aaaagttcat catcatttac 2094121 gggctgtttt cctgacattt cttttaacgt ttggtcagag aaaacaacaa atggcggaac 2094181 accctgctca gccgcaattt ctttccgaac catgcgcaat cgttcaaata gctcgtcatt 2094241 ttcagtaatc gctgccgctt ttaacgcttc ttttctcgct actgataatt ctcctttcag 2094301 cacattcctt cctttactgc tgacaaaaag agtcggaaac gttccgtctg acatcctgat 2094361 gaagtcgtca gaaataagaa attcgataaa atcactgatt tcgccaacgg attggtgttt 2094421 taatatcccg tatgttgaaa ggtcggaaaa gccgttttca agaacttttt tatttttgga 2094481 gccggcaagc acctgggcaa ccatcgtctt gccaaaccgt tctttcatgc gaatgataca 2094541 agataagacc atttgcgcct cccgcgtcac gtcatgggcc gctcttgtat cggtacagtt 2094601 tccgcactgt ccgcacgcat caggctcctt ttctccgaaa tacataagga taaaacgctg 2094661 cagacaatct tccgtatgac agtagtcgac catttgtctc agctttttta aatcctgctt 2094721 ttgtttctct tcatgttctg attgctcaat taagaagcgc tgcaccataa tatcctgcgg 2094781 tgaaaacagg agaacacatt cactggcaag accgtcccgt ccagctcgtc ctgcctcttg 2094841 ataatagctt tccatatctt tcgggatttg tgcatgcaga acaaatctga tatttgattt 2094901 atcaataccc attccaaaag cagaggttgc caccatcact tgaagctcat cattaagaaa 2094961 tctttcctgc tgctcttttc tcacatcatc agccaaacct ccatgatacc ggcctgccct 2095021 gacctgattt cgtttcaatc tctcatatat ccgatcagct tcttttctgg tcgctgtata 2095081 gacaattcct gcttcatgcc tgttgttttg cacatattcg tctataaacc gatctttatt 2095141 ttctcctttt actactttaa aggttaaatt ctctcgggaa aatccggtat ataccgtgtt 2095201 ttctttttga atatgcagct gtttgcaaat atcatcatga acctcgggtg tggctgttgc 2095261 tgttaacgcc atgatgacag gcttgtcgtg taattcacgg aacaagattt caatattcct 2095321 gtagcttggc ctgaaatcat ggccccattg agaaatacaa tgcgcctcgt ctattgcgac 2095381 caaaggaaca tctatgccct gcaaaatccg gataaactct atggacgtta gtcgctctgg 2095441 tgtaatgtaa aaaagcttat aagccccttc tttgagtccg ttcagcctct catatatttc 2095501 ctgattggat tgtgtgctgt taatgtaggc ggcgttaatc cccgcttctt ctaacgcatc 2095561 aacttgatcc ttcatcaagg aaatcaacgg tgaaatgacg atcgtcgtcc cttcaaacat 2095621 taatgccgga atctgatagc aaatcgattt gccgcctccc gtcggcataa tgcaggccgt 2095681 attttgcctc gcttccgtca ccaagcggat cgcttcatct tggccgctcc gaaacttctc 2095741 ataaccaaaa taatgagcca gaagggattg ggctctatgt aacataacgt gtaaacctcg 2095801 cttttccttg aatttctccc atcatatcat aaaaaagcgg ccttcatttc tttcacacaa 2095861 aaatggaata ttcactatac caaacctttt tagataaaat aaaaagccat ttccgaaaag 2095921 gaaatggctt tcgctacgtc ttgccgtatg caagtaagaa agttttaaac caccactcct 2095981 caaagtgggt gtttgcagaa acgttcctgt cgtcctctgc aatggaggca tgacattccg 2096041 gcttcgatat aaaactccct attacagctt aaaggttaaa acttaattaa caatacgcac 2096101 aaagtagctt ctttaatata gtacaccatc aggcgctttt aatcaagagg tcagaacaat 2096161 tgtttagaaa aactttttcc agtgaataaa actgtttttt ctccaaaata cctgacaatt 2096221 cgacaaacaa aaaatatatt acaataaaaa aaatagcctt tattgctaaa agcgaatgat 2096281 tattttcttc tatattaatg tgtatataca aaaagactcc tatttgtaac gataggagtc 2096341 ttggctttat tagaattttg cagcaagatc ttttgcttct tgtaaacctt tttcaacgat 2096401 ttcttgcgct tgatcaggtg ctgcgttatg tccttcgatg acaactgtgt gcaagtcttg 2096461 aacaccccag aaaccaagaa ctgttttcat gaagtttaat gacatttcaa gtgcagccat 2096521 tggtccttct gagtagacac cgccgcgagc gttaagaagc gcaacttttt tgccgcccat 2096581 taaaccgact ggtccttctt gtgtgtattt gaatgtaacg cctgcgcgag acagataatc 2096641 aacataagta tgaagcactg ctggcactgt gaagttccaa agcgggaatg cgaaaacaac 2096701 tttgtcagct tttacaaact ggttcagata tttgtcagca attgctgctt gttttttctc 2096761 atcttctgtc atttccattc cttgacctgc tttaaatgtt ccgttaatca tatctctgcc 2096821 aaggtaagga aggttttcct tatgaagatc taattcaacc acttcatcat tagggttgtt 2096881 ttctttataa gcagctaaga aagcttcgta aagtttagtt gaaacgcctt cttcagctgt 2096941 acggtcgctt gattttacaa ataaaactgt agacatttgt attcctcccg gtaaactttt 2097001 tatatttact tacaaatagt atgttacttt cttttttacg taaagtcaat cactttattt 2097061 tgaatatgag attttttttc aaaaaaagca agtacatcta atatcggtgt acttgcttgg 2097121 catttttact tcgaatcttg ttcacgatcc aagatttcat acgtctgcga gcttttttga 2097181 tcaattgttt ctttgttgga taagtctttt acctgttcat gaaactctct ttcataagaa 2097241 ggagcatctg tctccagatc atcctccaca tcagcttggg cctcaactgt cattcttgca 2097301 taaggaacag cttcaagtct ttcgtaagga atctcttggc cggttttttc acacacgcca 2097361 taagttccgt ctttcatctt ttgtaatgca cggttgacct cctctaacag ctcccggtca 2097421 atctctttca ctgtttggtc tgtcatccgg tctgtgacga gcgtcccgtg gtctgccata 2097481 tggttgtcaa ccccattgga aagctccccc acttcttccg tcattgattc tgtttccttt 2097541 ttctcgccag acaattcttt ttgcatatcg agcaatttat gatagagatg ctgtgtttgt 2097601 tcttttgtca gtgccatgta tatcctctcc tttctatcct gtttcccgtt ttgccttctg 2097661 tcaaacatgg aaacatcgat ggaaagatga gctactgcct ttttgaacgg atcgtgaccg 2097721 ctggcgtcga tggtgcttcg ggttttcgtt ggcacttttt gtccttctct tctggcggta 2097781 tataataggt tgcgcctata tttaatctgc cgctcagttc atcaatggtc agctcgccga 2097841 attcaagatg atagtcaact ttttcgacat tcagcgtttc aatatgtata taggtttctt 2097901 cagactcttg tttgctgctt tgtttttgtt tctcaatcac tgagagtctt tcttcacatt 2097961 cacgcagttt gtcaagttct ggtttcaagc aatgcctgat cagcgaccgg aacatttttt 2098021 tcatgacatc acgacccttt gcatactcct ctttcgtcta catatataat gaggtatatc 2098081 ccatagaaag gagaggtttt catgcttccg actaacatca atatttctca tctcaagact 2098141 aactcgatag gcaccggctc atcccttacc tttggttctg cggagttaag gaacaggtgc 2098201 tctgctatca aaagaaataa cggttttggg gaacaaaatg cagatggtat tgttatggtc 2098261 attccgattg aatcaattga tgaccgtgat gtgtcagatg cactcagtat gaaaatcaat 2098321 catcaataac aatggttttc gcttgacctt cgtctttttg aatagtgatg tataggattc 2098381 cgtctttaaa aatggcattc atctttccat gaagatgatc ggaaagcgga attttctttt 2098441 caaaacttcc gtatttccct tctttttggc gaaagtcctg ttcattaaaa taggaaaagc 2098501 gctgcccctt caccactaaa taatctccgt acgataatat gtgaacgtct tgtttacggt 2098561 agcctggaag ataaattaaa aactgcactt ccgcaacggt atctacaata tccatgctcg 2098621 gaaatgaagc atctcctttc cctcgctgat cttgctgcgc aaacggaaac ggagattggc 2098681 catttgtcat aaaaggggtt ttttggtctt catcaaatac ctgtttccaa aagtcaccgc 2098741 cgtacatctg ctgtgcgaat tccatccact gcttcatctt ttcgaaatcc atttgaagcc 2098801 ccctgtctta acatacttta taaccgccag catacaacta tagaaaggag gtttgcctgt 2098861 ggttcaacca actccgtata tcaatattaa tattttcatg ctgaaaatta attcctttga 2098921 aaatgcttca gcggttaacg taggacaaaa tttattggca gaatggcaaa attcagataa 2098981 aaaaaatcaa ggctacggac agaattttgg agatgcgagc ggatttatgg gcacgagaag 2099041 ccatgtggat gacagagacc aaattgattc tccggcctct tttgaaagtg aagcggttaa 2099101 ctcctcaatc aaaaggaagt gatgagatgt tcttttcacc ctccgtcgta aatgtcggcg 2099161 gatttaaaat caatacgatg gatcgaggtt cctctttaac actcggtccg tatcagcagg 2099221 tcgattactt tttatcagct aaaataaatc aagggtttgg agaagaaaat ggcgacttta 2099281 ctcctcttgt cgtgccgatt tcaaatgtat tagatgcaga tcttgttgat tcgaactcag 2099341 cgaaaaacag tgtggtgtaa taagaacagg gcgcacatgc cctgttcttg tttttatata 2099401 taaaaaaagc ctaaccattt tttgaacggc tggctcatca aatattcagc tgcacaaatg 2099461 ctttgtcagc accgcctgaa cctcgcttaa atcggtgtct ttcgcaaatt ctaattcgaa 2099521 agttttgctt cttgtcatca ataaaagccc agtgtccgga tcaaacattc ccgcttcttg 2099581 gatggcaaag ctttcaattg ttttatatgg aagaaataca cgaaccttct ttttagaaaa 2099641 cattttattg tcaaagaaaa tgatccgctt atttgtaaag caaatttggt ccactcggag 2099701 cttataaatc gattcaattc tttccccttc aacgagcaaa gcctcaagct tctttgcgtc 2099761 cgttgatctg ctaacagaaa aaatacccaa tgaagaaccc ctctttctgc atttatctat 2099821 ttgttttatc attcactaca taaaaataag tcctttatcc ctatataaga atacgacata 2099881 gaagacattt aaaccattac gaacagatta catttttcaa atttttgatt tgttttttgg 2099941 cttttaagct gttgtcatca agtaatacgc acatatagag aaaaaagttt caatattcag 2100001 caatgttttt ataaaaaagt ggtttttaat gattttttta attttgtttt atatttcctg 2100061 ttttaaccac aaaaaaaccg cagctgagct gcggttttat gtatcgactg cttttaacaa 2100121 aatctgtttg atgcttcaag gaagcattac atctcttcga agtattcttt ataatagccg 2100181 ccgactttat tcgtattgtc gaccacaaag agaaactcct ctgtttcatt ttttacttca 2100241 tattcttttc ccggcgttaa aacgcggttt acgatatatt tttttgcgtt tgtctgcaca 2100301 cactttactt ttttaatggt ttctttttca agccaatttt tatgaatcat gatgaaatct 2100361 ccttttctta tctataagct tattgtagct tttttctttt gtaaattgca atatcggtta 2100421 ttcattgatt ttgccttgat ttctattata gaatgtttgt atacgcttac gtttgaagca 2100481 actatcacag cttatttctg ctattcaatc caggaatcaa tgtgctatca ccaagaatct 2100541 cagaacagac cataaaaaat gactggaggt ttgttacgga tgagttcttt aacgatgcaa 2100601 gtgacgaaaa ggctggagac atttttacag ggaacaaaga agctttatat tgacggaaag 2100661 tttgttccga gtgcctcagg ggcaaccttt gacactccaa acccggcgac cggcgaaacc 2100721 ttgatgacgc tgtatgaagc ccaggctgcg gatgtggaca aagctgttaa agctgcccgg 2100781 aaagcctttg accaaggtga atggagaaca atgtctccag cttcgagaag cagactgatg 2100841 tataagctgg cagacttaat ggaagagcat aaaactgagc ttgctcagct tgaaacactt 2100901 gataatggga aaccgatcaa tgaaacgact aatggagata ttccgctggc tattgagcat 2100961 atgcgctatt acgccggctg gtgtacaaaa ataacaggac agacgattcc ggtttccggc 2101021 gcttatttta attatacgcg tcatgagcct gtcggtgtcg tcggccagat cattccatgg 2101081 aatttcccgc tcctgatggc gatgtggaaa atgggcgcgg cacttgcaac aggctgtaca 2101141 atcgtcctca aaccggctga acaaacaccg ctttcagctc tttatttggc agaattaatt 2101201 gaccaagccg gtttccctgc cggtgtaatc aacatcatcc caggattcgg tgaagatgcg 2101261 ggagaagcgc tgacgaacca cgaagcggtt gataaaattg cctttaccgg ttccactgaa 2101321 atcggaaaga aaatcatgtc caccgcagcg aaaagcatta agcgtgtgac attggagctg 2101381 ggcggaaaat cgcctaatat tcttctgccg gatgcgaatt taaaaaaagc catcccgggc 2101441 gctttaaacg gtgtgatgtt taaccagggc caagtctgct gtgcgggctc acgtgtcttc 2101501 attcataaag accaatatga tgaagttgtt gatgaaatgg catcctatgc tgagtcactc 2101561 cgccaaggag cgggacttca taaagatact caaatcgggc ctctcgtaag caaggaacag 2101621 catgagcgcg ttctttccta tattcaaaaa ggaaaagatg aaggagcaaa agcagtgacc 2101681 ggcggaagct gtccttttga agcaggatat tttgtcgcac cgactgtgtt tgcgaatgtt 2101741 gaagacgaaa tgaccatcgc aaaagaagaa attttcggac ccgtgctgac tgcaattccg 2101801 tacgaaacag tcgatgaagt tattgaacgg gcaaaccatt cagaatatgg gcttgcagcc 2101861 ggactatgga cagagaacgt caagcaggct cactatatcg cggaccgact tcaagccgga 2101921 accgtttggg tcaactgcta taatgtgttt gacgcggcgt ctccatttgg cggttataaa 2101981 cagtcaggac tcggacgaga aatgggatca tatgccttgg ataattacac agaagtcaaa 2102041 agtgtatggg taaaccttga agactaacat gtatgtttaa aaaactgctg cctgccagca 2102101 gtttttttct ttctgtaatg gcagtaaaag acgctgaata tatatgcttc tgaaggagtt 2102161 gagcgtgatg ggcacacttc aggagaaagt gaggcgtttt caaaagaaaa ccattaccga 2102221 gttaagagac aggcaaaatg ctgatggttc atggacattt tgctttgaag gaccaatcat 2102281 gacaaattcc ttttttattt tgctccttac ctcactagat gaaggcgaaa atgaaaaaga 2102341 actgatatca tcccttgcag ccggcattca tgcaaaacag cagccagacg gcacatttat 2102401 caactatccc gatgaaacgc gcggaaatct aacggctacc gtccaaggat atgtcgggat 2102461 gctggcttca ggatgttttc acagaactga gccgcacatg aagaaagctg aacaatttat 2102521 catctcacat ggcggtttga gacatgttca ttttatgaca aaatggatgc ttgccgcgaa 2102581 cgggctttat ccttggcctg ctttgtattt accattatca ctcatggcgc tccccccaac 2102641 attgccgatt catttctatc agttcagctc atatgcccgt attcattttg ctcctatggc 2102701 tgtaacactc aatcagcgat ttgtccttat taaccgcaat atttcatctc ttcaccatct 2102761 cgatccgcac atgacaaaaa atcctttcac ttggcttcgg tctgatgctt tcgaagaaag 2102821 agatctcacg tctattttgt tacattggaa acgcgttttt catgcaccat ttgcttttca 2102881 gcagctgggc ctacagacag ctaaaacgta tatgctggac cggattgaaa aagatggaac 2102941 attatacagc tatgcgagcg caaccatata tatggtttac agccttctgt cacttggtgt 2103001 gtcacgctat tctcctatta tcaggagggc gattaccggc attaaatcac tggtgactaa 2103061 atgcaacggg attccttatc tggaaaactc tacttcaact gtttgggata cagctttaat 2103121 aagctatgcc cttcaaaaaa atggtgtgac cgaaacggat ggctctgtta caaaagcagc 2103181 cgactttttg ctagaacgcc agcataccaa aatagcagat tggtctgtca aaaatccaaa 2103241 ttcagttcct ggcggctggg ggttttcaaa cattaataca aataaccctg actgtgacga 2103301 cactacagcc gttttaaagg cgattccccg caatcattct cctgcagcat gggagcgggg 2103361 ggtatcttgg cttttatcga tgcaaaacaa tgacggcgga ttttctgctt tcgaaaaaaa 2103421 tgtgaaccat ccactgatcc gccttctgcc gcttgaatcc gccgaggacg ctgcagttga 2103481 cccttcaacc gccgacctca ccggacgtgt actgcacttt ttaggcgaga aagttggctt 2103541 cacagaaaaa catcaacata ttcaacgcgc agtgaagtgg cttttcgaac atcaggaaca 2103601 aaatgggtct tggtacggca gatggggtgt ttgctacatt tacggcactt gggctgctct 2103661 tactggtatg catgcatgcg gggttgaccg aaagcatccc ggtatacaaa aggctctgcg 2103721 ttggctcaaa tccatacaaa atgatgacgg aagctgggga gaatcctgca aaagcgccga 2103781 aatcaaaaca tatgtaccgc ttcatagagg aaccattgta caaacggcct gggctttaga 2103841 cgctttgctc acatatgaaa attccgaaca tccgtctgtt gtgaaaggca tgcaatacct 2103901 taccgacagc agttcgcata gcgccgatag cctcgcgtat ccagcaggga tcggattgcc 2103961 gaagcaattt tatattcgct atcacagtta tccatatgta ttctctttgc tggctgtcgg 2104021 gaagtattta gattctattg aaaaggagac agcaaatgaa acgtgaatct tatcaagcgg 2104081 agatgttcaa ttggtgtgaa gccctgaaag atcagattca aaagcgaggt cagcttgacc 2104141 agtttgaaga tcaaatcgac aagatgattg aggctctgga agatgaccaa acaacagaag 2104201 aagattggta taaacaggcc gctgcccttt atcgggatat tacagaatca gatgatacaa 2104261 gtgaaagacg cgcttatgtc cctataggga aacacgtgct gccaaagctt ccttacaaat 2104321 actccgcctt agaaccttat atatcacgcg atattatgat ccttcatcat acaaaacatc 2104381 atcaaagcta tgtcgatggc ctgaacaaag cagaatcaga gcttaaaaaa gcgagagcga 2104441 caaagaatta tgacttaatc actcattggg aaagagagct tgcgttccat ggagcaggcc 2104501 attatttgca tagtattttt tggttttcta tgcatccaaa cggaaaacgg cgtcctacag 2104561 gggcattgtt ccaaatgata gacctttcat ttggaagcta ttccgctttt aaagaacatt 2104621 ttacccaggc ctctaaaaaa gtggaaggcg tcggctgggc cattctggtc tgggcacctc 2104681 gatcaggacg gctggagatt ttaacggcag aaaaacacca gctctttagc caatgggatg 2104741 tgatccccct tttaccgctt gacgtatggg agcatgccta ctatttgcaa tacaaaaatg 2104801 accgggccag ctatgtcgat cactggtgga atgtcgtgga ttggcgcgag gctgaaaaac 2104861 gttttgagca ggcaaaagaa gtcgtttgga agctctatta aaaaaagccc cctttcctcg 2104921 ggggcttcgt gtgttaaaaa atacctatca catgcaaaaa cacgatgatg atggcaacag 2104981 gagatagata tcgaatgagc agcagccaaa ccgcaaacca ctttcgtttg agattggaac 2105041 cgcttttcag ctcgtcaaac aaatcctgtt tcggtatttt tagcggaaca aaaatcgaaa 2105101 tcagtaacgc acctaacggc attaaaatat tgctcacaag atagtcagcc gcatcaaaaa 2105161 tagacagatg aaatatagtg acgtcactta agacaccgta tgataatgca gacggcacac 2105221 cgacaataaa aatagcaata ccgcctaacc aagcgaatcg ttttctctta ttgatatcgc 2105281 ctttcgacag tactgcgacc aaaatttcca gcattgaaaa agcagatgtc aatgcagcaa 2105341 ataaaaatag aagtaaaaat gctaataaaa agataattcc gaacggcatt tgattaaaca 2105401 cagtcggcag aacgttaaat aacagaaccg ggccttggtc tggcttgagg ccgaatgaaa 2105461 atacagctgg aaaaatcgca attccggcca ttacagcaac aagcatgttc ataacagtta 2105521 cagatacagc ggactgtacc agattttcct gtttctctaa ataagcgcta tacgttacca 2105581 tgacagatac accgacactt aataagaaaa aggattgtcc cattgcatat aaaatggtat 2105641 tggcatcaat tgcagttaaa tcaggcatga ggaaaaattt gattccttcc atcgcgccat 2105701 caagtgtaac cgaacgcacc attaaaatga tgaataatag aaaaagcgcc ggcattaata 2105761 cttggcttgc tttttcaatt ccgctgctta ccccttttgc aacaactaaa attgttacca 2105821 ccataaagag cagctggcct cctacagcca aataaggatt tgaaatggta cttgcaaata 2105881 tcgtatcaaa accagatgtt tgcgataaac cgccagtgaa gccttttata atataaatta 2105941 aaatccatcc gcctacgaca ctgtagaaag atagaagaat aaagcacgtc accatgccta 2106001 aataaccgat ccaatgccac ttcgttcctg gagcaagtgt tttataggac tgaacggcat 2106061 ctttctgtgt tcttctgcct atgatgaatt cacctaacaa taaaggcagt ccgattaaaa 2106121 ccgtaaataa aataaaaata agtaaaaatg cgcctcctcc gctggttccg gcaacatatg 2106181 ggaatttcca tatcgcacca agcccgatag ctgatcctgc cgcggctaaa ataaagccga 2106241 gcttcgaaga ccattgattt gcttccttca ccgtatcact cctatttgat ctaaccatta 2106301 taaaggttca ttgtaagaat atcttcctat atagtcaaga acattttaat tagtttacat 2106361 catatatcta tagacatctg ccaaaaacta atattgaatt attcagaaaa ttatttataa 2106421 taagagaatg ttatgaaatt tgtaagaatt tctgctgaag ttcttgataa gtgtgttagg 2106481 agtgttttta tggacatcat tagaaaaata agccattttg caggacaaac ctttggcata 2106541 tgggtcattg tttttgcagt gctgggattt tctttcccat ctttatttac gtggatcagt 2106601 tcttatatta cgatttttct cggcattatc atgtttggga tgggccttac actgcaagcc 2106661 gatgatttca aagagctggt cagaaagcct tggcaagtta ttattggagt aatagctcag 2106721 tatacgatca tgccgctcgt tgctttcggc ctcgcatttg ggcttcatct tccagctgaa 2106781 atcgcagttg gtgttattct tgtcggctgc tgtcccgggg gaactgcatc taatgttatg 2106841 acattcttag caaaaggaaa tactgccctt tctgttgcgg ttacgacaat ttctacctta 2106901 ttggcacctg ttgtaacacc gttgttgatt atgctgtttg ccaaagaatg gcttcctgtc 2106961 tcgccggggt ctttgtttat ctcaatctta caggcggttt tatttccgat cattgcaggt 2107021 ctgattgtca aaatgttttt cagaaaacaa gtggcaaaag ccgtacatgc ccttccgctt 2107081 gtttctgtca ttggcatcgt tgcgattgtc tcagctgtcg tcagcggcaa tcgggaaaat 2107141 ctgcttcaat cggggttgct cattttttca gttgttatcc tgcataacgg tatcggttat 2107201 ttactggggt ttctttgtgc aaagctttta aaaatggatt acccgtctca aaaagcgatt 2107261 gcaatcgaag tcggcatgca aaactccggg cttggggctg cacttgccac ggctcatttc 2107321 tcaccgctat ctgccgtacc aagcgcaata ttcagtgtgt ggcataacct ttcaggttct 2107381 atgcttgcaa catattggtc aaaaaaagtg aaaaagaagc aagctggatc caaaagcagc 2107441 aatctatcac tttaaatatg catcaaaaag ggtacatcac tttatcgtga tgtacccttt 2107501 tttattatcc ttctaataaa agctgttcag gatcttccag taaatttttg attgtcacga 2107561 ggaaaccaac cgcttcttta ccgtctacaa ttcggtgatc ataagataaa gcgatataca 2107621 tcatcggacg gttttcgaaa cgctcttcat caatggctac agggcgcagc tgaatcttat 2107681 gcatgcccag tataccgact tgcgggctgt ttaaaattgg agttgacatc aatgaaccga 2107741 aagtccctcc gtttgtaatc gtgaaggagc ctccctgaag ctcgctaagg gttaatttat 2107801 tgtttcttgc ttttttcgca agctcgccga tctctttttc gattcctgca aatgtcaggc 2107861 gatccgcatc ccgtacaacc ggaacgacaa gaccttcatc agcagcaaca gcgattccga 2107921 tatcgtagaa ttttttaacg atcaactcat cgccttgaat ttctgcattc aacagcggat 2107981 attttttcaa tgcagccacg accgctttcg tgaagaaaga cataaagccg agcttcactt 2108041 cattttgctc aaaaaattga tctttgcggc gttttctgag attcatgaca gccgtcatgt 2108101 ccacttcatt aaatgtagtc agcatcgctg atgtttgctg tacctctaca aggcgttttg 2108161 caatcgtttg tctgcggcgt gacatttttt gcacttcaac aggtttgtca aagctttgct 2108221 gtgctttttg agcctgaggc tgctgctttt gctgaggagc cggttttgat gccggttttt 2108281 cgtacgcttc gacatcctgc ttgcgcactc ttccaagcgg atctccagtt ggaacttgag 2108341 acaggtcaat tcctttttct ctcgcaagct tacgggccga cggagaagcg atcgttcttg 2108401 attttgcttc agattgtgct tcctcgctca cctcttgtgc agctggttca gcctgtttct 2108461 cttcttttac gctttccttg ctttctgttt tctctgtagg agcaggggca gaactttcac 2108521 ccgcgccttc tgaaatcgta ccgataattt ctccgacctg gacggtatca cccgaatctt 2108581 tcaatacctc ttgaagtaca cccgattctt ctgctgtcaa ttcaacattc actttatccg 2108641 tttctagttc aagcagatat tcaccctgtt ctacatagtc accaggctgc tttaaccatt 2108701 gggctattgt tccttctgag attgattctg ctaattcagg taccttaatt tccgccattt 2108761 tttcatttcc cccttagttt ttgcgagtca agctatcaga tacaatacgt tcctgttctt 2108821 ttttatgaac tgtcggatct ccctctgcag ggctggatcg tcttcttcgt ccaatatatt 2108881 gaacgcttac tccctctggt gcaatctctg tcaaatacgg gctgatataa ccccaagccc 2108941 ccatgttctg cggctcttcc tgcacccaaa cgatttcttt caggttcgga agttttgcaa 2109001 ataattcttt gactcctttt gccgggaatg gatacagctg ttcgattctc gcaatgtgaa 2109061 gccactcttt accgtcttct aacttattaa aatgatcgct aatgtctata gacactttac 2109121 cgctggataa tacaagtctg gttacttttt catagtcatg agaaagtccc gactgttcat 2109181 aaacaggctg gaagcggctt tcgctgagct cctgcacttc cgacaccgta tttgggttgc 2109241 gaagaaggct cttcggcgtc ataatgacga gcggtctgat ttcttcacga agcagcattt 2109301 tagcctgtct tcttaaaata tggaaatact gtgccgcgct tgtcaggttg gcaaccgtcc 2109361 agttgttttc cgctgcaagc tgcaggaatc gctcaattct tccgcttgag tgctcaggcc 2109421 cctgtccctc gtaaccgtgc gggagcagca tgactaatcc ggatttttgg ccccatttcg 2109481 cgcgtccggc agaaataaat tggtcaaaat acacttgagc agcgttggca aaatctccgt 2109541 actgtgcttc ccacaaaaca agcgtttccg gtgaatgcac gttatagccg tattcaaaac 2109601 cgagaaccga tccttcagac agcgggctgt tatgaacagc aaatgatgtg ctgcagtcag 2109661 ataagtgatg aagcggcaca aattctttgc ccgtctcact gtcatgaagc acaaggtttc 2109721 tttgggcgaa cgttccgcgc tcggaatcct gtcctgttaa acgaatcggt gttccgtctt 2109781 tcaaaattga agcaaacgcg agtgattctg ccaaagacca ttccactttt ctgtcatcat 2109841 cgaacgcctt ggcgcgtctt tctaaaatgc gctttagctt gccgaaaaca ttaaatgact 2109901 ccggccagtt gatcaattcg ccattcagct tgcggagcac atcaaaatca atcgaagtgt 2109961 ccacatctgg gaaaccgttt gatacaggct ctggaagttc aatttcacaa gcagtgtgtt 2110021 cctttttaga cggaactttc tgatatgcat cctcaatgcg cttcgttacc gatttttcga 2110081 tgttttgaac gacttcctcg gtaaccacgc cttcttttac cagcttttca gcgaaaattt 2110141 gtttgacggt cggatgcttt ctgacagcat catacagcat tggctgagtg gttgacggtt 2110201 catccatttc gttgtgtcca tagcgtctgt acccgatcaa atcaatcaga aaatccttgt 2110261 tgaatgtttt tcggtattcg accgcaaact taacagctga aagacaagct tcaggatcgt 2110321 ccgcattcac gtgaacaatc ggaatttcat aacccttggc caggtcgctg gcatattttg 2110381 tcgatctgga ttcagcgctt tctgttgtga atccgatcat gttattggcg ataatatgaa 2110441 tcgcaccgcc tacttgatac ccttttaaag agcttaaatt caatgtttca gctacaattc 2110501 cttccccagg gaatgcagcg tctccatgga ttaaaatggc cagcgatttt gtttcatctt 2110561 gtaccgggta tccgctttgt gttcgcgttt cctgtgccgc tcttgtgctg ccttcaacaa 2110621 tcggattgat aaattccaag tggctcgggt tgttcgctaa cgtaatgcgc gctgattttg 2110681 tttcagcgtc ttgaagctcc cgattcgccc ccaaatggta tttgacatcc cccgtccatc 2110741 cgtagctgat tccaatggat ccctcagacg gtacaagatc tttgttcggc gcatgctgga 2110801 attcagagaa gatgatttca tacggtttgc cgagcacatg tgccaagaca ttcaggcgtc 2110861 ccctgtgcgc catcccgatg ttgacacttg tcgtgcctga tttgacagat tgtgcaataa 2110921 tgtcatcaag cactggaaca agagcgtcca gaccctcaat ggaaaagcgc ttctgcccga 2110981 cgaatgtgcg gtgcaaaaac tgctcaaagc cctctacttc tgtcaatctt tccagcacag 2111041 ctgacagctt ttcagctgag ttcttctgga acagctcgcc agattcaatc tttcttgtca 2111101 gccactcgcg ctctttgaag tcatgcacat ggtcaaattc aaaagagatg gttcttttat 2111161 acgtatttcg taaatactga atggcttcta aaccgttcga aatgttttta ggagcgtctt 2111221 tgcagatgac agacgcaggt attgctttta tttcctcttc tgttagcccg taatcggata 2111281 atggaaaaag ttcgctcttt ttctcatcct ttctgagcgg attgacggaa gcgttcaaat 2111341 ggccataggt tcggatatct tctgcaagtc tgactgcgga tgcgatcttt tgaatcagat 2111401 cggctgtaac acgtcccttt tcttttgttc ccgaggcctc ttttatatcg cttggcggag 2111461 caccgagctc gtcgaacatt tccttcaaat ccgggtcaat gctgttcgga tcctgggtat 2111521 actgatcgta aagctccagc gcatagccga ggttcggacc gtaaaaatct tcccaattca 2111581 ttcgttgttt catactattt tgaaacattt gaatattacc cccaacttaa ataatcaagt 2111641 gattgattca ctatcttgaa ataactttcg aacgctgtgt ccaaaattat gtaataaaaa 2111701 cgcttccaac gatattttac cactgtttgc aatttgattc taccttgatt gttcacaaaa 2111761 tagtaaaaaa cctttataaa aaacaaaaaa tttaatcatt cgaaaaaaca aacgccaaaa 2111821 agcataggat taagggctat cctatgcttt tatgaagcag ttttttcagc agcggataca 2111881 aaacatccgg tagctgatca acatccggga caaatatact gaattttccg tacatatcct 2111941 ggatcgtctt catttgcgat tcttctattt ctgagttgga gagaaaaaca tttatcactt 2112001 ctattcctct ttttcgggct tcgataaccg cctcacttgt atcaacgatc ccattttgtt 2112061 cgtagccaaa tgcggccggc tctccatctg agaaaacaat taagaacttt tgcgcctcgc 2112121 tgcgatgcag catttttttc gtcatctgcc taattgcgta cccgtcacgg ttatcttctt 2112181 ctggctcaag ctgcataatg gccggtccag aatcttgtct taatgatgat tggaagggaa 2112241 taaccgtatt gaaatagttt ggctggcttt tttcggttgc atcatttgtg tcctcccaaa 2112301 aaccgacaat ctgatgcgga accgctaccg atttcaacgc ttcgtgaaac agcacgattc 2112361 ctcgttttgt ttcgtccatt ttgtcgaaca tgctggcgga acaatcgacc agcaatgtaa 2112421 aaactgcgtc gatttctgaa gatggttctt gctttttgta gaacaggcgc ggatttcgct 2112481 cagtgaagta acgaagaagc ttattgttca gtctcccggc atgaaggtct gttctcggca 2112541 atgttttttt atgctccagc gttttttgaa tcatttgttt caaacgcttt tgatacgatt 2112601 caatcgtttt tgcctgctgt ttataagaaa gctcttcttc actggttgcc ggctgcggtt 2112661 ctttataaat tggaaatgca tatttatttt ctttgccgtc agccataccc gctccgttcg 2112721 gctggtcttt ttgggactcc agcgcttcca gcttggaata gtctttccgt ttcgtttgtc 2112781 tggctgatcc ttgaacagag ccaagggcct gatctccatc gtcgccttcc cttgaagcat 2112841 cttttcctaa atctgatttt gcgccgtgtt caatatcaaa ttgaaggaag cttttagacg 2112901 gtgcttctgt ttcccggtgc catgtcggca tttcttcttc atggatatcc tcatcaccgt 2112961 ctgattgttt tggaagcgtg atgtcatcac tcagcttcgg cgcttttttc tcttcttcaa 2113021 ataacggctg ttctgcagct tttgcgtaat caagctcagg caaaaagaag taggtgttca 2113081 acatgtcttt atcgagtacc tcttcaagtc cgtccatgag gtcctcaaca attttcagaa 2113141 cctgccgtgt cgaatctgct tcatacacac gcaagagctg ctgctcaata aacgggcgca 2113201 tcagatcgat atcttcacgc atggatggaa gggtctcgag cggcgattcc gctgtgagct 2113261 tgaaatagat cgcgcaaaag agcgcatcgg taaaaatgct tcgttccaaa tttaaggtca 2113321 gctgggttga gaaatgtttt ctgtacatgt cttttcgctt cgcaaataca tgtttcgtac 2113381 ccgggcgctc acgtttgatg cattcttcga tcctaatgtc ttcaagcagc ataaagagct 2113441 gcttggcaaa acttttaaac gtaagatggc gatggatatc attcaaaaag ttcgcaaact 2113501 catgcagcga gctatatctt gttccgactg aacgcaggta gacgtcgctt ttcagacccg 2113561 cttccatgtc ctcagctgcc ctgtctttcc aaaagtggct catatagatt ttcttttcaa 2113621 atggattgta ataggactga acgccatact ccacttctac cgcttcactc ttggtgagtg 2113681 ttttggccaa atcagtcagc atcataaata aaaatgaatc aatcgtgctg tcgttaaatt 2113741 tgataaattt catcgcagcc ccctcattca aacagagttt ctgcaatatt tcggacagcc 2113801 gctttttccc gatcatcatc aagcttttct acaattcccc gctcaatggc acgacgcggc 2113861 ggaatataag cagctaaatc acatgtatcg attaaagctc tgatggatgc cgcttcttca 2113921 gacacctgtc cgttattggc ctgaacgatc aagtcagagg aaagcgtgat aaatctgtca 2113981 atcaatttct cgtctttcaa ggctgactga gacatgagca cttgtttcag cagctcgcct 2114041 ttaatataag gcacatcaat gatgacaaaa cggtttttca acgcttcatt cagaggaaca 2114101 gttccgacat agccttcatt gatggctgca atgactccga aaccgctttt agcccgtatg 2114161 acctcgcctg taaacggatt tgtcatcatt tttctgtaat ctaatacacc gtttagaata 2114221 ggcagtgttt ccggcttcgc catattgatt tcatctatat aaagaaaatg gccttccttc 2114281 attgcctttg taacaggtcc tgaaacaaac tcgattgttg cctggccaga ttgattttca 2114341 atcgttttat aaccgaccaa tgcctcagcg tccaagtcga ctgaacagtt gacgctgtgc 2114401 atcggtttat gaaaatagct ggacaatgtt tctgccagct ttgtttttcc tgaacctgta 2114461 ggccctttca gcaggacatt tttccccatg gctaatgcaa taatggcgtc aaataaaatg 2114521 gcttcatcct ccgcctcata gcctgatgtt cctataagcg attgaaactc tggggaaata 2114581 ggctgctctt tatatgataa aagcttttgt tgtatatctt ccggcaatgt taagtgctgt 2114641 agttgagttg tcatagacag attccctttc ctattcatat tccattaacg agtatactaa 2114701 aaaagcccct gtatgctcaa tacaaaaggg cctggatgat attactgctt ctcgttattt 2114761 cccaaaaggg ctccgcagac aatacgcgca ccggaattgc cgcttgggtt tgtcagataa 2114821 tcgtccgctt gttcatgaat aataaatgca cttccgtcct cgtcgagaat atttagttta 2114881 cttccttttt tcagtgaagt gtcaggcgca ttcattatga catctacctt tccatcagca 2114941 ccgacttcaa ggttcggcag atctccggca tgatgcccca tcggattatt aaagccgtgt 2115001 tctttgttca gtggattaaa gggaccgccc gctgattcaa aatccggcct gacacaagaa 2115061 cctttctcat aaatatgaaa accgagagaa gcacctggac gcaggctgtt tgcggaaata 2115121 tgaatatcga ggccttcatc atctgattct ttgatctcta taaaaccgac tgctttccct 2115181 tcacgattga ccagctggac atgatgacca aacgctgacg tttcaaccac ttttttttcc 2115241 ggcacccggt taggagggtc tggaggtttt ttttgtccgc atccggcaac tcccagtgcc 2115301 gtcagcatca tcaacagcaa gagacggtgc atactgtctc ccccttgttt tttctaacag 2115361 tgtggtcaat cattgtctgg tataaacaaa aaagcctata aaaggctttt tgtcatactc 2115421 atttttaaaa ataacttctt gcgcccaagt accgctgttt ccaatacgaa ttgctgagat 2115481 tggaaatgtc gacgcccgat gagcttgcat gaataaaatc accgccgcct agataaatcc 2115541 ccatgtgaga cgggccggat ttatatgtgg taaagaagac aaagtctcct actgacggct 2115601 ggctgacttt ctgcatgaca ttccaatacc ctgccgtact caatcttgat atagatgata 2115661 cattattaat gaggtaataa atgaagccgc tgcaatcaaa accggcaggc gtgtttccgc 2115721 cccatcggta aggcactccg acatattttt tcgcttccgt tatcattctg tcaatcttcg 2115781 aacctatttg aatgtttgac cctgagttat cttttggctt tgttggcttt gtcggatttg 2115841 aaggattaga ttttgatgct cccgaaatag tcagaacctg cccgatttgc aacacatccg 2115901 atgataaatt gtttttatca cggatgcttt ggacagtgac tccgagccga tttgcaattt 2115961 tccacagcga atcgcctgct tttaccttgt acgtcgttgt ttttgaggga ttggagtttg 2116021 acggcttttt ggaaccgctg tttccgttct taggtgaact gcttcctttt attttgagca 2116081 cctgtttagg ataaagtgta tctgatgtta agccatttaa ggtttttaat tcggctacag 2116141 tcatatttaa gctgtttgcg attttccaca gtgagtcacc aagcttgacc gtatatgtac 2116201 tttttgaaga acctgaagaa ttggaaccgc tgtttttctt tgatccattt gatccgcttg 2116261 aactgcttgt ccctttgatc ttaagctttt gccccggacg aatcaggtca ctgctcaggc 2116321 tgtttaagct tttaagctca gaaacactca ttttatgatt tttagcaatc atccataggg 2116381 aatcaccata tgcaactgtg tatgttgatg ttttgcttga attagatggg gatgtcgtgc 2116441 tttttttgct gctttcagga accttaagac tttgtccgac ataaagcacc gttgatttca 2116501 atttgttttc ggatttcaga gctgatattg tcgtatcata ctggcgggaa agtttccaaa 2116561 gagagtcacc gctttttact tttatcgttt ttgcttccgc gggtgctgcg gccatcgacg 2116621 acccaacaac tgcagaaaca gccaagccgg ctacaatctt ctttttcatt cattcaacct 2116681 cctaaactgt ttttttgcaa aaacagctag tattttgttt ccaaaaatgg cacacaactg 2116741 ttttatcgtc aatttttcag caagttaaac ccttttcaaa catttggcgc agcattttca 2116801 gcatcgttcg acctttaaac cttcaaataa acatctaaca ttttacataa gcacgatatg 2116861 tttttcgaaa gtctaaggaa ctatttaagc gagggtaaaa atgatggttt tctattgatg 2116921 aacgaagcag tttctcctcc tttcttgtct atttttctaa tcaattctct atcggcgtgt 2116981 caaatccctt cctctgcatt cttatgaaat ggcaaaaagc ctgttctttc gataagaaca 2117041 ggcttttaca ctatgcattt gctgattgag ttttttgttt tacagcttca agaatgctgt 2117101 cggctgcttt tttagagccg cctgccgctt tcagtgattg tccaatttct tttgcctttt 2117161 cagcatacga acgattattc attacttctt gtatcgtctc tttcagtagg ctttcagaca 2117221 attcttcctt tttaattact tttcctgcgc cgactttttc tacctgatct gcgacaacaa 2117281 attggtcgcc tcccatcgga atgacaacga gcggggtttc aaaatacaaa ccttcacttg 2117341 tgctgttcat tccgccgtgg gtcacaaata agctggctct tttcaagatc tcaagctgag 2117401 ggacatacgg gcgtacaatg aaattctccg gaatgtcgtt taactcactt gttttaatat 2117461 gcttgccgat ggaaagcaca actttaccgt caaagtcctt acacacttca aggcattgat 2117521 taaaaaactg cttttgatta ttaaaaatgg ttcccattga aataaacagc acgttttcat 2117581 tgtcaatctg atcaaatggg aaatcattgt ttccggctct ttctgtaatg gaaggaccga 2117641 caaatacata tcgctcgcca aattgctcag ccagtggctg aaatcccctt gatgtaaaga 2117701 cgattgtcaa gtcaccatca gctaaaaaaa catcaaatgg cttcttgatc tctgcttgaa 2117761 aatcagcatt taacgtttct gcaagctgct ggtatgattc ataatgaggc gaatcttcaa 2117821 gtgatccttt catgtacgct cccatcattt ccttcgcaaa ttcctcattc atcgcaaagg 2117881 ttgtacacaa tgaaaatctt ggcagcttca gcatgttggc aatgacttta cccgcgagaa 2117941 gatggtgatc atatatgaca taatcatacg attcatgttt gacttcctca taaatatgag 2118001 tcgcgatatc cttacaggct ttcaaaaaag cgcagagcat ttctgtgaaa tctctttctt 2118061 catcgccggt tgcgtttttc ccgaagtaat ctcctctgaa atcatgatac tcacgaaact 2118121 ctatatcaag agctgtgatt ttttctttat attccttcac tgcgtagtac gtaatgtttt 2118181 ctccccggga tttcagctcc ttcatcacac cgatagaggg attaatatgc ccttcaccgg 2118241 ggaaaccgat cattaataca ttagccatgc ggcagcaccc ttcctttgag aatttatgta 2118301 atattttata cggtactata aatgcataaa caggtaaagt atttcactta attaatattc 2118361 atcatatata acttttctac cagtttatat tccctgtctt caagacaaaa agcattcagc 2118421 ttgaagcgaa tgctttaata aagatgcgaa ttcagtcatt ttgtctcatg ataggattct 2118481 taatcaggcc ctttttatta tttttacgtt cttggtgaaa ttaacggata taatacaccg 2118541 tctttggcaa acgacatctt ccctgtttcc tctgaaacca cgagcaccag tgcatccgta 2118601 tagcccgaca taccaagagc cgcccggtgc cgggttccca aatggatatc cacttccttc 2118661 gtcgtcagcg ggagcacatt ggctgctgac acgagtttgt tttccctcac taataaagcg 2118721 ccgtcatgaa gagggtttcc gggaaaaaag atgctttcaa ttaatgaaga gctgatctcg 2118781 gcgtgtaggg aggtgccttt ttgaataaaa cgttcaaccg ggtctgctct ttcaatcaca 2118841 attaaagctc catgcttatg ttccgataag gctttaatcg ccttggccag ctcaataaat 2118901 gccggcgtaa attcctcaat gtatgattgc aaataaaagg aggatgcaat cccctgcatg 2118961 tcctgaaaaa cgtgccccaa atcatctaat tcacaaagga gacactggtc tttttcgtga 2119021 agcgttttca agattagaga tgcatcacct aatatttgct ctaagtacac ctgtattttc 2119081 cccttgaacg cattttctga tatctgctca tagcgcatag ccttcatctc ctgtttaaat 2119141 ttccaacttt tcacgaatgc ttatcttatt gatgcacatt ctattggtaa aggagggatg 2119201 taaagaatgg aaatcgaaag aatcattcag tatatttgca cctttttagg cgtgatttcg 2119261 ctttctttta tttatgccca aatgtttaga aaaacgaaac cgacaaaaaa agaataggcc 2119321 cggcgttcat tgctttttat acataaaatg ttataatttc tctcgttatg aaaaagaaac 2119381 ggagatcaat gtatgaaaga aactcaaaac gcccgggaaa aaatcaaaca gctcttgcac 2119441 attttaatac cgatattcat tacccaagcg gggctttctc tgatcacttt tctagatact 2119501 gtgatgtcag ggaaagtcag ccccgctgat ttagctggtg tcgccattgg ctcaagcctt 2119561 tggacccctg tttacacagg acttgcaggt atattaatgg cggtcacccc gattgtcgct 2119621 cagttattag gtgcagagaa aaaacagaag attcccttta ctgttttaca agctgtatac 2119681 gtggccgcgc ttcttagcat cgccgtttta gtgattggat atgctgcagt tgaccttatt 2119741 cttggccgat tgaaccttga tattcacgtg catcagattg ctaaacactt tttaggcttt 2119801 ttatcactgg gaattttccc tttatttgtt tacaccgtgt tgagatcatt catcgactca 2119861 ttaggaaaaa cgagagtcac catgatgatt acactcagtt ctcttccaat caattttgta 2119921 ttgaattatg tatttatctt cgggaagttc ggaatgccgg cacttggagg tgtaggcgcg 2119981 ggactggcat ccgcgttaac ttactggtgt atatgcatca tcagtttttt cattattcat 2120041 aaaaacgcac cgttttctga atacgggatt tttcttacca tgtataagtt ctcttggaaa 2120101 gcatgcaaaa atttgctcaa aatcgggctg cctattgggt tcgccgtgtt ttttgaaacg 2120161 agcattttcg cagctgtcac gcttctcatg agccattttc atacagtgac catcgcgtcc 2120221 caccaggcag ccatgaattt tgcgtctctt ttatatatgc tgccgcttag cgtgtccatg 2120281 gctctaacaa ttgttgtcgg atttgaagcg ggtgcagccc gttttaagga tgcacgctca 2120341 tatagcttaa tcggcatcat gatggcgatc ggcttttctt tgttcactgc cgcctgtatc 2120401 cttttattca gagagcaaat tgcgggcatg tacacttctg accccgatgt gctccggctg 2120461 acacagcact ttttaattta tgcgctattt tttcagcttt ccgatgctgt tgccgcaccg 2120521 atccagggag cactcagagg gtacaaagat gtgaactata cgcttgcggc cgcttttgtc 2120581 tcttactggg tcattggcct tccggtcggt tatatggtcg gtacgtttac aagcctcggt 2120641 gcattcggct attggattgg attaatagcg ggactcgccg ccggagcagt tgggctgttt 2120701 ttcaggctgg caaaactgca aaaacgttat tcgcaaaaac aacacattta aaagaggtga 2120761 tcaatcatgg caaaaaacaa aaaattattc gagtatcttt cccagcatgc ggaaaccatc 2120821 agttcaacat ggtatgaaac aatcgaggag actgatccca attccattta tgcctcaaca 2120881 gaccctgttg tcattcacaa tttaaagagc cagaatcttg cctttaacta taaaataaac 2120941 cgtattttta tagatgatga ggacgtatac ttgcctatac tgaaagaatg ggcctttgaa 2121001 gtcacacagg atcaagagca tttaaaaact cctatccact atattattcg ggagtttgtc 2121061 agagtgagag atttatatgt ttcttatgtg aaagaatttg tccatctcaa tcagaatact 2121121 gtgaaaagcg aagaagccga agacctgtat cacgccctta taaaagcgtt tgatcttgtg 2121181 attcatattt ttatagaaga aatgtacaaa aacacaagcc ttcagcttca ggcccaaaaa 2121241 gatatgatta ctgaattgag cgctccggtc atcgtgctgt ttcacagcgt cggactgctg 2121301 cctttaatcg gagatattga tacagtccgc gccaagctga ttatggaaaa cacactgcat 2121361 caatgtgcga aaaaaaaggt gacacaactg tatattgatt tgtcaggagt agctgtgatt 2121421 gatacgatgg ttgcccatca gctgttcagt ctgattgagg cgcttcgttt aatcggtgtt 2121481 tcttcaactt tgtctggaat ccgtccggaa atcgcgcaaa cagcggttca gctaggtttg 2121541 tctttcgaag gtatttcctt gagatccact ctcgcttcag ctattgcatc ggacttaaaa 2121601 ttaaaaaagg tataaggctt aaggccttat acctttttga ttaatcattc cattgatacg 2121661 tccaatatat ttcttcttca aaccatgttg ccataacagg ttcattattt ttcaatttct 2121721 cttcaagctc tctgagcatg ccttctgttt gtgtgcggtg agctcttaac gcattcattt 2121781 taatatcagc tacttctttg atatcaagta cgacatcagc ttcgccgaga acctcttctc 2121841 tgttgcgggt aatggccatg cagattgtac gcggacggtc ttctttcttt ttgcggtata 2121901 atgcacggat aaccgcttcc ccgcatgcat catggtcagg gtgcacaccg tgtccgggat 2121961 aaaatgtgac aattaaactt ggttttacat catctatgat ctcttccatg atatcagcta 2122021 aatactcatc gtcttcaaat tcgagcgttt tgtcacggag tccaagcatc cgaaggtcat 2122081 tgatatccat ttctttgcaa gcgttgatga gctcttgttt tcttagcagc ggcaacgttt 2122141 cccgattcgc gaaaaatgga tcgcccatat ttctgcccat ttcacctaaa gtggcgcagg 2122201 catacgtaac gggaatgtct ttttttctgt ttaaggcaat gaggcctgcc actccatatg 2122261 attcatcatc agggtgaggc aggattacta gtacatgttc tttcattatt attcaccctt 2122321 ttctttaaac tgtgaacggt ttttcgctga tttgcagaga aatagccagt ttaccgcccg 2122381 gcaggtgtcc cgccattaat aaacggtttt cttcatctac cgtgtattca gtcaagcctt 2122441 cagcataaat ccagccttct tctgttttca agccaacgcg gtaaggcccg ttgcctttga 2122501 tttttgcctg atgataagtg acttttgcat tgcgaatata cgcaacaacc gtcatgttct 2122561 tttcatttaa gtgcgctgaa taagaacctg tggtggtttc taaatggata tatacagggc 2122621 ggtccgcata tcgttctaaa gatgcttgca catcttcttt tatgatcgct ttcatgattg 2122681 ctcccctctt tcttctttta aatactctgc acgttctgta tgtaatttga ccagctgata 2122741 tttcacagcc ggttcgagct gtgaattcac aatgcgctga atcgcggcaa aatatttttc 2122801 cagcatcggt tttcggagtc ttggatgtgt tcgtttatcc aagagctcaa gatcaatcgc 2122861 ctctgctacc gcttctgcgt catcatgtgc gagagatcgg ttattccaaa gtgaagcata 2122921 ggctttcact atctctttat cattgtccat cgtcttgctc ctttatgtct tacatacatg 2122981 aaatgattat acataatata tgcatcagct gaaaagccaa aggcctcaat ggctttttga 2123041 cgcccgtttc cacttcactt gtgaaaacgt aaacaagagc agcgcagccc atatacagct 2123101 gaatgtaaaa gccttcgagc ttgaaaatgg ctcatggtaa acaaacagcc cgatcagcag 2123161 ggtaatggtc ggcgcaatat attgtaagat accgacttga tacagtggca gccgtttcgc 2123221 tccttccgca aacaataaga gcggcaaagc cgtaaacaca ccggccaaaa agagaagcag 2123281 ccacgtccct ccgctttctg cacccgctgg ctgaacatgt ccgctgaaca gcaaataccc 2123341 caatgcaatg ggcataatca tgaatgtttc cagcgttaaa ccgatggcgc tcggcaggct 2123401 tgttcttttt ttgcttaacc cgtacagccc aaagctgaat gcgagcagaa gcgcaacata 2123461 aggaatggag ccgtattgga acgccgagat gatgacaccg gctgccgcaa tcgaaacggc 2123521 cactaattgc aggcgattca gtttttcctt taaaaataaa atcccaagga gcactgatac 2123581 aagcggatta atgtaatagc caagactagc ctcaagcaaa aagccatggt tgacagccca 2123641 tatgtataca aaccagttga tcgaaatcag gatagaagca agaaataaag agaggatccc 2123701 tccgttcttt ttcagagagc gcaactcctg ccatcctatt ttccattgcc gcaagaaaaa 2123761 aagtacgata cacataaaaa caaaagacca tataatacga tgagccaaaa tatcaagagc 2123821 cggcagctgt tcgagaagct tccaatagag cggaaacagg ccccacatga taaatgaaac 2123881 ggctgtgtaa ataacgcctt tttttgtttc tgcatgttgc attgatatcc ctgcctttct 2123941 ttagagcatc ttatattata tcacgtgaaa gatctggtgg gcatatacta ttttgtccgt 2124001 gaagaaagga tgtgaagaca atgtttgagt ggaacaagta ctttcctttc cacaatcaat 2124061 tttctaaaga agcattaaaa aaagctgatc cgaaagaagt tgaaacgtat gtcaatcgtg 2124121 tgatggaaag tgtgttcggc agtgattatg cggctcaatt tcctttccgc gatcctctcc 2124181 cccaaaaaga acatcccgcc aaacctgatg caaaacctga tgtcaaacct gatattgata 2124241 tattcgaaac agcagaccat gtgtttgtaa aggtgccaat cagcgaagaa tggctggaac 2124301 aagtgagaat caaacacaca tctcacgaat tatggttgga aaacctccca agagcagatc 2124361 atccgaaaaa agtaaacctt ccttgtttag tcaaacgcaa aggaacaaaa gccgtctata 2124421 aggatggcct tctggaagtc atgtttcaaa agcagcaaga ctacaatatg tccgaggtag 2124481 aaatcatccg ataaaaaacg gcctgcaatc gatgcaggcc gttttttatt aatagaagcc 2124541 gggatatccc ccgtatggca cgccggcacc aaaaccgtac ggtccgcctc catatccata 2124601 agggccagga ggataggcat agggacgaga atagttaaac agcgcactcc cgagaaaacc 2124661 gcctaataaa ccgccgacta gaggagcgcc aaacaaaaaa ggactacgcg ccggatatcc 2124721 ggctggacct gggattccgc gtaaatacga atgatgaggg tacatgattt tttcctcctt 2124781 tatgtctgcc tatacgtaaa gtattcagca aggaagaaaa acgattgggc tacggactgt 2124841 ctatgattgt tacatcacaa gccctgccaa taacacacag ccgagccctg taaccgaaag 2124901 aactgttgta agcagcgtcc aggtttgaaa tgtttctttc atgctcaagc cgaaaaattc 2124961 ctttaccatc caaaatcctg catcatttac atgacacgca atgacactgc cggctcctgt 2125021 tgcaagcacc attaacgcag ggtttacact gccagcctcc ataagcggag ctgccattcc 2125081 cgctgtggta agcgcagcca cggtagcaga gcctagacac agacgcagaa ccgcggcgat 2125141 ggtccatgca acgaatagcg gcgacatgtt tgtttgacgg aaaaaatcag cgacataatc 2125201 gccgactccg ccgtcaatca gcacctgttt aaacgctcct ccccctccta tgatgagcag 2125261 catcatcgca atttgcgaaa ttgattctga aatagatctg ccgatttcct gcatagatat 2125321 tttacgggca tatcccatcg tatagagtgc aagcaacagc gaaatgagca ttgccgttcc 2125381 cggagtgccg ataaattcta taatgtcttt tccttttgaa tgttcactca ataataaaga 2125441 aaaaattgtt gccattgcca taaagataac cgggaataaa gacgtgacag cactgatcgc 2125501 aaagcccggt gtttcatcca gctgaaattc tttccttggt cctaaccccg ataggtttcc 2125561 atgcttttga tacgcaccag gaaaccgttt catcgcaaat ttattaaata aaggcccggc 2125621 aatcacagtt gtcggaacag cgatgatgat tccaaaaagc agcacctggc caatatgggc 2125681 accatatgca actgagatag cagttggagc aggatgcggg ggcaaaaatc cgtgagtaac 2125741 atttaaggcg gcggccatcg ggattcccag atacagaaaa ggcattttta attctttagc 2125801 aatcgcgtaa acaatcggta tcaacagaac aagaccgact tcaaaaaata gggcaatccc 2125861 gatgataaaa gaggcaacca caaccgccgc ctgtattcgt ttcctcccga atttgtcaat 2125921 cagcgtaatg gcgatccggt agccgccccc agcatctgag acaagcctcc caagcatcgc 2125981 gccaagtcca aacactaaag ctaaatgccc cagctgcccg ccaattccag tctcaattga 2126041 aagaacaatt ttattgatat ccattccaag tccgatggct actaaaaatg aaacgacaat 2126101 cagtgagaca aaggtattta attttacttt aataatgaga aataacagaa tcagcactcc 2126161 gacagctaca attaaaatcg gcatggtacc cctccaaaag tgttttatat gattctcgcg 2126221 acaatgtttt ggcgcttttc atgcctagat gaacagaaag cgctttcatt aataactaaa 2126281 aacgtcttgg ttatatgatt gttatctttt gatcaactaa tatgttcata ctaatctcct 2126341 aatcaatgac tgtcaatcgt ttttatgagc ttgtctcgat tacctaccgc ctaacccaat 2126401 gatttattag ttatatgttg attaactttt ggttatatgt tatgtttttt aaagttgact 2126461 gccaatcatt atatctctcc attgtctgga agcaaatgag acaatatgag aacagacgga 2126521 taacaacttc ataagaggag gagtacacat gccattattg cgttttgatg taattgaggg 2126581 ccgtgatgaa aaatcgctgc aattgttatt agatactgct caccaagcga tggttgaagc 2126641 atttggtgtt ccggaaagag accgttatca aattgtccat cagcatcccg caaacgagct 2126701 tataatccag gatgcgggat tagggtttca gagaaccaag gatatggtca tcattagcat 2126761 gacaagcaaa gcaagaaccg aaagccaaaa ggaaaaattg tatgctctgc ttgctgaaag 2126821 gctagaaaaa aaatgcgaaa tttcccctga cgacctcatg gtatctatta ctgagaatgg 2126881 tgacgcagac tggagtttcg gtctcggtga ggcgcaattt ttgaatggaa aactataaga 2126941 tttcgtctcc ccacaaaaaa aagaagagag agctccaaag aagctctctc ttttttcata 2127001 aatgcggaag tcatcagtat agaagcatcc agcaatacga aaaacctgga tctcctttta 2127061 tatccggttt aaatgccaat tggaagctga ctgggttttg gctgaaaata taaaattttg 2127121 ctgatttgca taataagata catcataatc cccatttaca ataggttgga tgttatagct 2127181 tattgatcat ttcctatttt atatatcccc ttcatatgca catgacattt ttgccaatcc 2127241 ggaaatatca gtctgacaaa tataaaaagt catgtaaacg ggtgtgaacc gtacttacat 2127301 gactcaccat ggaaacaaag gctctttttc aggtgccgct ttccttattt ctcttcttca 2127361 cacactgtgt caccaggctc gcaaaattga tcggcccatg cctgcatttc ttgaaataca 2127421 gcttgaagcg ctgttccttt ttcagtcagc gtgtagatga ctttgaccgg cgtttcaggg 2127481 agaacctgcc gttcgacaat ctcgttttgt tcaagctcct tcaagcgctc tgccaacatt 2127541 ttttggctga tcatcggtat tgtttccgtt atctctttaa accgtttcgg cccatccatt 2127601 agcacatgga tgatcagacc gttccatcgt tttcccagca atgagaatgc ggattccatt 2127661 ttagggcaca tcgtatttcc cataagtctt catcccttca tctattgatt gacatgtatt 2127721 caatgatcca ttacaataat ctttcaagtt acatttagta agcttctaac ttttctatta 2127781 tcataccacg tttatccgaa ggaggaaaca ctatgacgaa tactctggat gttttaaaag 2127841 cacgtgcatc tgtaaaggaa tatgatacaa atgccccgat ctctaaggag gagctgactg 2127901 agctattaga ccttgccact aaagcgcctt ctgcttggaa ccttcagcat tggcatttta 2127961 cagtattcca cagcgatgaa tcaaaagcgg agcttcttcc tgtagcgtat aatcaaaaac 2128021 aaatcgttga gtcttctgct gttgttgcca ttttaggcga tttaaaggca aatgaaaacg 2128081 gtgaagaagt ttatgctgaa ttagcaagcc aaggctatat tacggatgaa atcaaacaaa 2128141 cattgctcgg ccaaatcaac ggtgcttacc aaagcgagca attcgcacgt gattccgctt 2128201 tcttaaatgc ttctttagct gctatgcagc ttatgattgc cgcaaaagca aaaggttatg 2128261 acacttgcgc aatcggcgga tttaacaaag agcagttcca aaagcaattt gatatcagtg 2128321 agcgctatgt tccggttatg cttatttcaa tcggcaaagc agtgaagcct gcgcatcaaa 2128381 gcaaccgtct gccgctttca aaagtatcaa cttggctgta aggatatgaa aaaccttagt 2128441 ccgaaatccg gactaaggtt tttttataca atcgcctctt tgtaccattc acgagcctgt 2128501 tcagcttcat gctgagtcag ctgatggccc ccgtcctgcc agtaaacgga ggctgatgcc 2128561 ccgctgtcac gcaaatagcg gtaaagctct tctgattctt ccttcgtgca aagaggatcg 2128621 tatttcccgg caccgataaa aacagggagc cccgccatat caggcagctc gataccccga 2128681 atcggaacca ttggatgatg cagaatagcc ccttttaaca catctttata atgaaaaagc 2128741 aggcttgccg caatgtttgc gccgtttgaa taaccgactg caatcactcg gccgcgatta 2128801 aactgatgcg tttctgcagc ctcgtcgata aaatctttca attctcttgt ccgcaccaca 2128861 agatcctttt catcaaaaac tccttcactc agacgtttga aaaatcgcgg cattccattt 2128921 tcaagcaccg atcctctgac accaagcaaa tgggcatcag ggtctataaa ccgccccaat 2128981 gaaagcagat cgtgttcatt accacccgtg ccatgcaaca gcaaaagtac gttgtcagat 2129041 gttcctttct cataaatatg cttcattata aattccccct tttaaagttc aggtaaaatg 2129101 tctgtaattt gttgtctatg tttctccagc cattcaggca gttttaagga agtccctagc 2129161 tcagcaaacg tttcatctgt cataaagccc ggttcatctg tggcaatttc aaataagata 2129221 ccgcctttct ccctaaaata aactgatgta aagtattccc tgtcgagaat ttctgacgaa 2129281 ggcagatggt tttcagcaat aatcggcagc catttcgcct gttccttttt cttagtccga 2129341 aacgctacat ggtgtaccgt accatatcct ccgactcctc ttttttcagg atgtaaatgg 2129401 acatcaatga caccgccgac cgccgctgaa gatgccagtc tgacaatctg gtcttcttcg 2129461 gccactttgg tgtatccaaa gctttccgtt aacaattgta tggtcgcctg cgggtcgtag 2129521 gaatatagca gcacaccttt cattcccgta attgcttcat ttgttgtgat cccgtcaggc 2129581 gtccactcgc ttttgccgct tttcgcatcc tccatgatcg ccagcggaag gtcttctgta 2129641 tcatcaaaaa taagaccttt ttcaccaaac aacgtttttt cctctaggct cagcccgctt 2129701 ttctcaagac gttccttcca aaaagacagg gagcctgagg gaactgaaaa gtacacccgg 2129761 cccgcttggc cttttcctac cgttccctgt ccgcttcctt ggaacggaaa aaaggtcatt 2129821 attgtaccgg gatctccgtt ttgattccca aagtaaaaat gatacgttcc gggatcatca 2129881 aagtttactg tttttttaac gagcctgagc ccaagcactt ctgtataaaa tcgcaagttt 2129941 tcttgcggat ctctggcgaa tgctgtgaca tggtgcaatc cttctgtttt cattttctca 2130001 ctcctattta tctcgatttc aagatattta ttattttaaa cctttattga aaaggatgca 2130061 aaccatgtgt tttgattaaa taattgaaaa aatcattttt ttctaataat tatcttgtga 2130121 tcttttctta caactgctat tatagtgagc attatcatgt ttcaggagga aagtaaatgg 2130181 ttaaaaaagc acttattgtt attctcattc ttttgccatt cgttcagctc gcgcttttgc 2130241 cgcttgtgaa tcgaatagaa ccgattatgt tcggcctgcc gtttttccac ttttggctgc 2130301 tgctgtggat tattgttacg ccgttatgct cgtttggcat ttatcagatg caaaaaaaag 2130361 atggaggact tgaataatgc aagggaatct gactgcactt ctcattactg ctattattgt 2130421 tttaaccgtt gtctgtatcg gctttctcgc cggaagagac aaatcctcac gtacttctgt 2130481 ggaagaatgg tctgtcggcg gcagacgctt cggcggtctt ctcgtctggt ttttagtagg 2130541 cgctgacctt tatacggcct atactttctt agggttgacc agtactgctt ttacaggcgg 2130601 aagtgttgca tttttcgcca ttccttattc tgtgttggcc tactttatcg cctacttctt 2130661 cttgccaaaa ctttggaaag ttgcgaaaat tcataaatta acaacactcg cggattatgc 2130721 ccgggaacgt tttaacagta agcttttggc aagcctcgtt gccatcgttg gggtactcat 2130781 gcttattccg tacatatgcc ttcagctgag cggcattcaa gacacgcttc aggttgccgg 2130841 cactggctat attaacgtaa aattcgttgt gatcatttca tttattcttg ttgctcttta 2130901 cacattcttc agcgggatta aagggcccac atatacagcc atcattaagg acattttagt 2130961 atgggtcatt atgctgttta tggtggtgtc cctccctctc attcatttta acggctggac 2131021 gccaatgatt gacacgttag tgaaggaagc gccgcaaatg ctgacgatac cgtcagaagg 2131081 gccaaaaggc attccttggt ttatcacagc atctattgtt tccgctctgg cactttttat 2131141 gtgggcacat gccgctacag gtgttttcac ggcgaaaagc gctgatgcag taagaaaaaa 2131201 cagcatgttt ttgccgcttt ataatatcgt gttaattttg gttatttttc ttggctttat 2131261 cgcctttctt gttctgccgg aagatacaaa tccaaggctg gcgctgctgc atttgattca 2131321 aacatcttac ggcggcgtgg cacaaggctt tgcatatgcc actatcgctc ttgcttcatt 2131381 aataccttgt tccattatgg caatcggcgc atcgaattta ttcgccaaca acctataccg 2131441 ggatttgatt catccgaatg tgtcgcaaag caagctgact cttgtcacac gttcaatggt 2131501 gtttgttgtc atcggtcttg cgctgctgtt tggaatgctg ttcccgactg ccttagtgac 2131561 acttcagcta ttaggtgtat ccggtatggt gcaaatcttc cctgcgattg ctgtcagcct 2131621 gttctggaaa aaccaaacga aagaagcaac ggttatcgga ttattagccg gcctagcggt 2131681 aacgtttatt gtgtatatca ctcaatccgc acatggcatt tatgaaggat tctggggatt 2131741 ggccgccaac atgatcgctg tggtcatcct gaatccgctg ttcgttaaaa acgcgggatc 2131801 caatcctgtc attgaaggtt tatttggcaa aaaacaagac gctaatccaa atcaaaaggg 2131861 cgcataaaaa aaccatacgc ggcagccgcg tatggttttt tttacatttc ttttttcagt 2131921 gtttcaattg ccttttccat ttgcgtatca ttatcagaca gcttcttttg aagttctatc 2131981 attaatttcg ttgttgtatc gccagtcagt atgcctgttt cattcagctt ctcttttttc 2132041 tggaactgtt tgacgacaga tacaaaatcc tggtcataca tactgttaac ctttaccttg 2132101 taaccaagtg ctttgagcat tttctgagcc actttgacgt ttgtgcctgt atcacctgat 2132161 ttgtacgttt tatctgcgtc caaatacggc agcttcgcgt aatcaggcag ctctgctttc 2132221 acttgaggct tgatgccttt tttgtgaatc cattcgccat cagcagtcag ccatttggca 2132281 actgtcagtt tgacggtaga gccatcatca tattcttttg ccgtttgtac tgtacctttg 2132341 ccgaatgtcg tctcgccgat taacggtacg tttgacgatt catgaagggc agcggccata 2132401 atttcggctg cgcttgctgt accgtcattt actaaaacga cggtcggctt ggtcactttc 2132461 cgttcttttt cggccttcat gacttctttt gaaccgtttt tgtattcaac ctgcatgatg 2132521 tttttccctt tatcaatgaa caggttgctc atcgtaatcg cctgttccat taagccgccc 2132581 gggttgcctc tcaagtctaa aatatagcct ttggcgcctt ttttctctaa actgtcaatc 2132641 gcatctgtca gctctttagc tgttgtttca gagaaagaag tgatttgaat ttctccgatg 2132701 ttgttgtctt tcatctctga atagacagtc tctacaggaa tggtatcgcg cttaatggaa 2132761 agatcgatat tccccactcc cgctctgttc agttcaagct tcacctttgt gccctttttg 2132821 cctcggatta aagcgacggc ttcatttaca ttcatgcctt ttacgctttt tccatttacc 2132881 ttaatgattt ggtccctcgg tttgataccg gctttttcag caggtgaacc tttaattggg 2132941 gatacaataa ggatttctcc gtctttctcc tctacttggg ctccgattcc ttcaaaagat 2133001 gctgaaatcg tctcgtcgaa tgatttcgct tgctcttgat ccatatatgt agaatacgga 2133061 tcatccagtg attgaatcat tcctttaatt gctccgtcta ctaatttgtc atcatctgtt 2133121 ttttggtaat aatcactttt gatttgctca tacgctttat ttaatttgtc gaacttgctg 2133181 tctcctgtgc ttgctgattt ttggcccagg atactggaat tgcccgtaat aaataaagta 2133241 agcgccgaag cgacaactgc agtgatcagc acaataaaaa acagttttaa ttgccgtttc 2133301 aattaaacac cacctttttc ttcttacatt attatcatgg acgaattctt attcgtcaac 2133361 tcggagcaga aatgaaagag aaacgccctt cttttgcttt tcataaacct atgtctttat 2133421 acgacatatg ataaggaaaa aggaggattc gatattgagc cgatatttag aaatgctgtc 2133481 cttattcggt gtcgcagggg cgcacccagg cgggctggct ttttcaaaag cggtcttgca 2133541 aaaggctgca ccctctccgg atcagccgat tcttgatgcc ggatgcggaa cagggcaaac 2133601 ggcggcttat ttaggacatt tgctgtatcc tgtaacagtc gttgataaag atcctattat 2133661 gcttgagaaa gcgaaaaaaa gatttgcgaa tgaagggctt gccatccctg catatcaggc 2133721 ggagctggaa catctcccgt tttcttctga gtccttttcc tgcgtcctgt cagaatcggt 2133781 cctcagtttt tcacgcctga catcctctct tcaagaaatt tcaagagttt taaaacccag 2133841 cgggatgctg attggtatcg aagctgcttt aaaaaaacca atgccccctg cagaaaagaa 2133901 gcaaatgatg gatttttacg gatttacttg cttacatgaa gaaagcgaat ggcataaact 2133961 cctaagatcc tatggctttc aaaaaacaga agcgatgtca cttcttccgg aagacatgga 2134021 atttgaacca accacagaaa tggatttatc gcaaacgatt gatcccatct attacgatac 2134081 gcttcaaaca cattatcagc tcatgcagtt atatagtgag tacatgggtc attgtatttt 2134141 tatcgcgtac aagtaaaacg gcgtatcgcc ccctgttttc gtccaacctt tttttcctat 2134201 ctatcatatg ctgatagaaa gtcaggatag gaggggaaca atattggaga gatattatca 2134261 tctttgcaaa aaccatcaag gtaaagtcgt cagaattaca gagagaggcg ggagagttca 2134321 cgtcggcaga attacccgtg taacaagaga cagagttttt atagctccgg tcggcggagg 2134381 gccaagaggt ttcggttacg gatattgggg cggttattgg ggatatggag cggcttacgg 2134441 gatttccctc ggtttaattg caggagtggc tctggctggt ttattcttct ggtaagcata 2134501 gaacaaatgc tagattcacc agacacaatg aagcccgctt atctagtgta agcgggcttt 2134561 tcattttaaa ttttcttcac tttttcaaag tactcttcaa gcgttaaatc attatcttgg 2134621 atgacctttg cggctttttt gcctacatag cgcagatgcc atggctcata ttcatatttc 2134681 gtgatatctt ctttattttt cggatagcga ataataaagc catatttata agcattgtcc 2134741 tgcacccatt tcccgtctgc cgtgcttccg aacgcttcat ttagctcaaa gccattgctc 2134801 cggctcgaaa tgtccatcgc aaggcctgtt tgatgctcgc tttcacccgg gtaagcgacc 2134861 gcttcctttg ccttcctttc cccttttagg cttacttcat tgtcaaaaat gactttctgt 2134921 ctgtcatacg aacggtaccc tgagacagct gccagttcat agccttcctt tttggcagca 2134981 tcgaacattg tttttaatgc gtcggccgct tcttttctga tgtaacgttt ttgaatcttt 2135041 tcttcaaaag aaaactctac atcaggtatg acaagatcgc taggttcata gtttccgggc 2135101 agtgcatatt gtttattgac aagcgcgagt atattttctg gattttgaat ggtttccaga 2135161 ccatcgactt ttttaatatc attgaaatac tggctttcca atgaaaactc actgttttga 2135221 gtgtttgatt ttttgctgtc agctgttttt tgttctgttt gctttgtttc tgctgtggtt 2135281 ttcgtatcct tttgagcatc tccgttcgac atgctgcagc cggctccgac tattgccgtt 2135341 acactcagag cggcagccag tgagaaccat ttaccggact ttttcatatt acattacctt 2135401 ccttttatca atcgtttccg catgcataaa gaagaggctg ccggcaccca gcacgcctct 2135461 tgatatattt tattgtgata cggaatgtaa agccacttct atcatatcat gaaatgtcgt 2135521 ttgacgctct tccgctgtcg tttcttctcc tgttaatacg tgatcactca cggtgagaat 2135581 tgacagggct tttcttccgt gcttcgctgc taatgtatac aatgcagttg tttccatttc 2135641 aacgccaagc acaccgtatt ttgcaagttt ttcaatttgc gaatcgtcat tgtagaactg 2135701 gtcagctgta aatacgcttc ctacagtcac cggcacacct ttatcctttg cggcatcata 2135761 ggcatttttt aaaagctcga aatctgcgca aggcgcaaaa tcaacgcttc cgaaagcaac 2135821 tctgttcatt tgtgaatcag ttgaggaggt catcgccaaa atgacgtctc gcactttgac 2135881 atctttacga atagcgccgc aggaaccgac tcttattaga ttttgcacat cgtagctttg 2135941 aattaattca ttcacataaa ttgaaataga cggaactccc attcccgtgc cttgtactga 2136001 gattttttta cctttatatg tacccgtaaa tccatacatg cctctgactt cattgtagca 2136061 ttctacattt tcaagatacg tttctgcaat aaattttgct ctgagaggat ctcccggcaa 2136121 aagcacagta tccgcaattt gtcctttttc agcacctata tgtacactca tctcatatcc 2136181 tcctgtaaat ctaaattatc atccagcccg tccattttac aacgaatgtc atgatgaaac 2136241 aaacttcagc attgattata aaggaatata tcgaaaaaag aaatgttcga ggatctgtta 2136301 ggcacttcct cagaaaaacg gataatcggg gtgttaattt gaaaacctaa ccgcaggaag 2136361 gaggggtggg acatgggtaa aaaacatcgt aaccggatca ccggccaaaa aaagaacaat 2136421 catatacctg aaaaagatat cattgcagct gaagaagcac acgggaaaga atattccgct 2136481 gccaaacgca agccttaaaa ctgcagaaaa ctgcgggttt ccgcagtttt cttttcatta 2136541 tgtcgtttgt acaatcagac gattgatttt cctccagccg gcgggaagca gttgataata 2136601 tgttttccct tttctgcctt catcaatcag gatcacgtcc cctgtggcca tgaatcttgc 2136661 atcataatca ctcggaacag tgtcgaatac attaaacaaa gagaatgctc ttttcagcac 2136721 gtcttgatga tcgctcccgt tcagttcagt tcgatagacg gctctgtagc cctttttttc 2136781 gccaaaccgg ggtgtctgaa atattgtcac gtcataggaa caagacttct ttttaaacac 2136841 ggataacatc atcaagatcc cctccctttt atttctttaa catattggcg tttttgctgt 2136901 gttttcctct ctctattttt gtcgaaaccg cttaatcttt tcgtcaaaac cttttactag 2136961 gaaaaacaga agcaagccga ggctaaagcc tcctaacacg tctgtcacaa aatgaacccc 2137021 cagatacact ctgcttatgc cgactaaaac agcaattaca ccggctatga tatataccat 2137081 ttttttatgc ttagacaaaa acgggagatg tttcactaaa aagtaagcaa taacaggata 2137141 gacacaagca gcattcatgg aatggccgct cggaaaactg aaggatgatt catgaaccag 2137201 cggtgcaaaa tcaggcctca ctctttcgat ccattctttt aagactttgt ttaacagccg 2137261 atctgtgccg aatactaaga gcatcaacag gccgtcccat gtttttctgt agaaaaacat 2137321 gcctgctcca atgatgacaa ttagagggag cagaaaagaa gaagcaccaa gatgcgtgat 2137381 ccccgtcatg acttcattaa gccatggctg acggatcaaa acagctgcct tgcttattgc 2137441 ttcatctgca gattgaacag catttgtatg aatggccgca gctagaatta aaaagaaaag 2137501 aaacaaacta acgggcttgt acaattttaa ccacctcaat tttcacagaa gtcatagaac 2137561 atgaataata aaaccggagc tgaccgctcc ggttttaagc ctcactcatc ttcatccagc 2137621 tcttcatcta tcatacattt ttctatcaaa taatcaaagg taatatcagc gatttcaaac 2137681 agctcatcct cactcggtat gtagccccgt cttgcaagct ctctgtaaaa aaattcagcg 2137741 atttcttccg tatcaatcac aagatctatt tctttcatct ccgtaccgcc tcctttttta 2137801 tgttttatga aaaaacaggc tgaattatac ccggtgttct aaacaattct ttcagtcata 2137861 tattgaataa aaaacgagcc atgggaggct gacgctatga ttgctaaaat gatggaagca 2137921 ctggacggag aaagatttga tatcataatg gaaaaaacgc tcaaaggaat gacgcgtgtg 2137981 atgatttggg gctgtctgcc atatttttta tatgtcttga tccgtatgtt cacaaattaa 2138041 ctgaaatgct cttttaaact ttccaaaaca aacatcatca tgtctttata ttcttcatcc 2138101 tgaaacattt cgtacagaat tttgtagtca ttataaatat ccagaagctc atcaacaatt 2138161 gacacagcaa ggatgtgaag ggtatcttga tcttcatcac cgccttcaaa ctgaagaaga 2138221 gcagacgatg cgatatcttc gccgatctca tggccagttt ctccgacata atggacaaac 2138281 aacagctgat gcacaaactg gtccatttca tattttctaa gcaccagcgt gagatcctct 2138341 tcctccgttt caagccactc tccatccttt aaacgggtca gctcataaat gatatcttcc 2138401 cagccatctt ctaaatatct ccaaatttct gttctatggc cgataatgcg aaagagttct 2138461 tttccataat ctttaacata aacaacgtcc ccaataagga attcatactc aatatcaagc 2138521 ttctccatgt cgacaatgac accctcataa tctttataaa gctgaataga tgattcaaag 2138581 tataaaactt cgttatgatt gacttcataa agatagtgtt tatcaatttg gtgtactttt 2138641 gtgatggtgc cgactgttcc atacataatg acgactacga tatcccctac ttggaatttc 2138701 ggtttatttt gcttcatggt gtctccccct cgccgcaaca tttctcatac gctatcgtat 2138761 gccgggtgaa gccaattcgc atgggcatga aaaccaaagg aaatatccaa ttatggtatg 2138821 ggtatggaca taaaaaaatc cgcagtgatc tgcggatgaa acagctatta tctgccgtgc 2138881 acttcagact cgtattgatc ccaagcttca tcaaacgtcg ccatcgtgtg aaggtaatca 2138941 gcattcagct ccaaatatga actgatttca tgataatcgg ttgatgtttt tggaaagctg 2139001 tgatcctcat acgcctgatt ggcaaattca ctgatgctgt ccttcggctt agggtgtctg 2139061 tatttcaata aatagtgata aaaggatttc atgggtttcc cctcctgatg tctgtctttt 2139121 gttgttctat tatacagttc aagtgtaaaa ttacaacaaa agaatactga aacatgactc 2139181 aggagaagtc aaaatagttg cgtttcaaaa ttctttctgt ctccatgagc tgctgatatg 2139241 tcaggctttc aggcagtttt tttgtttgaa ttaaaagcag ctgatcctca atctctttaa 2139301 ccgtgttttc ctcttgatag gtcataccgc aggaagaaca taccatggca ggggtgtctg 2139361 tcagttctat agccctcgtt ccatcaggga gctcccagta caccgtgttc ctgccgggca 2139421 ccgcttcgag ctcgccgcac cattcgcatg ttttcatgaa gaatcccctc cgcattcagt 2139481 ctctttctgt tttttctgct gcgccaaaaa tttcttttct ttgagctgat ctcttttctc 2139541 acgccgatct tttaatgttt catgctccgg atttgcgatg tatgcctctc tccttttgat 2139601 tctgtctaca ttttcaggtg taaacgaaac ttctttgtca gcaaaaatgg cactcagccc 2139661 gatcggctcc tttttgtcag cggtttcagg gaaaacggac tcaaaatagg cgtctgcctg 2139721 attggggata taattctctg gttccggata tgacgtaatc acaccttcaa aatttcttaa 2139781 gatcactttg tcaggacttt gtgacaggac atagtttggc tgcagggcga ttttacctcc 2139841 tccgcctggt gcgtcaacga caaaggtagg aaccgcatag cctgaggtat gacctctcag 2139901 cccttcaatg atctccaaac ctttggaaac aggagctctg aaatgcccta ttccttctga 2139961 cagatcacat tggtaaatat aataaggacg gactctgatt tttaccaagt catgcatgag 2140021 ctttttcata attggaaccg aatcattaat acctgctaat acgacagcct gatttccgac 2140081 cggcactccc gcgttcacca gcttttcaca tgcctcaacg gattcttctg tcatttcgat 2140141 gcttgtgtta aaatgggtgt tcagccagac cggatgatat tttttcaata tctcgcacag 2140201 atgatcggta atgcgctgcg gaaagacgac gggagctctt gttccgattc tgatgacttc 2140261 cagatgcgga atgctgcgca gctcttttaa aatatattct aaaatttggt cgttgatgag 2140321 cagcccatca ccgcctgaaa ttaaacaatc gcggatttcg ggtgtttccc ggatataagc 2140381 aattgcagca tcaagctgtt ttttggggac gcccattccg atttgtccgg aaaagcgcct 2140441 tcttgtgcag tagcggcagt acatggaaca ttgattcgtg acaagaaaca gcacacggtc 2140501 gggatagcgg tgtgtcagac cgggtaccgg tgaatcttca tcctcatgaa gcgggtcttc 2140561 cagatcgtat tttgttttgt gcatttcttc agaaagcggc acagactgca tgcgtaccgg 2140621 gcatctcgga ttgtcggggt ccattaaaga agcatagtaa ggtgtaatat ttaaggggat 2140681 cgttttggta gaaattctga cgccttcctc ttcatcctcg gtcagattaa tgactttctt 2140741 taaatcatct aacgttctta cagtgtgtgt cagctgccaa agccaatcgt tccatttctc 2140801 ttccggaacg tccttccata actcgatctc cttccaatgc cgtttcggtt tataccattt 2140861 gtttttcaaa cgaactcctc ctcgcgcata ttttgactta cagttgcttg caccaaatat 2140921 tcatgttttc aaggccttcg gctataaagc aattattgat cagccttccg ccatactgat 2140981 aacctgaatg gtacaacaca gcattcatcc caaaagacga agcacgggcg agagaaaaca 2141041 catgaacgat atcctctcca gccatttctt tttctaacgc ctcgattaaa aagcttgtta 2141101 acgaatggcc gcgatattcc ggcagcacag cgcaatcggt tatttctgca tgcccaagct 2141161 ctggattgat ttctgcgctt gctgcgctga tcaggcggtc atgatcaagc atgatataat 2141221 acaccgtatt tgcattcatc gtcttttcaa tataagcggg gtcaaatacc ggggttgggt 2141281 acgtgcggaa tactttttta tacagcatcg atagctggta catgtcgttt gtttctgctt 2141341 ttctcatcgt aaaaacgggt gtactgtcgt tgcgaagacg gggcgctgtg cgatatatgg 2141401 cttcgatgat ctcctgttcc tctgtataag aatctgtttg tctccggctt tctgaaaggt 2141461 aacgtaccat gacacaagcc gaatggccga gataatagcc ctttagatag ccctccggcg 2141521 caaataattg tttggcaagg atcggctcat catgctgctt cgcatagaca atgatttttt 2141581 ctgcattctc ttcttttgcc gctgccacga tatccggcag ggccttctca atggctccgt 2141641 cataacgaac cactctgatt cgtttattaa agccgtcatg gtccaaaact gctgtgacac 2141701 cgctactctt tattgacttg agcatccgca tcctccccat ctgtatgaag gccgcaccaa 2141761 tccatgacaa aaagtgcaat aattttagca gattctatca tggcttcaac ctcaatgtat 2141821 tcattggcct gatgagccgt ttttgtttcc cccggcccga aaacgatcac tggtgtatct 2141881 cctgcatggt acaaaagccc tccatccgtt ccccacgggg aagcctcaat aatcggctct 2141941 gtctgtttca ttttttgata ggctgattgc agcacagaaa ttaaagggtg atcatcaggt 2142001 aaatcattcg gcagccattg agcgccaaac cattcgactt gtacgggatg gcgtttaaac 2142061 cattcgtcat ggtattctaa atccttcagc cagttttcca attcaagttt tacagcttct 2142121 ggtttctcat ggggagcaat tccgcatctc ccttctatga cgacacggtc tgcaactgaa 2142181 gatggccagg caccgcctga gatggtgccg atattcaccg gtaccggtat tgggatattg 2142241 tcatacagcg gatctgaaat tctcgcattg cggactttct ccagctcttg tatcgctgtg 2142301 ataacgtgca tgcttttttc aatcgcgctt accccttcat agcgtgtgcc cccatgtgcg 2142361 gataatccct tcacagtgat ccgaaaccac atcgaaccct gctgcttaat aaatagtttc 2142421 atattcgtcg gttcaggaat cagcgccccg tcagcacgat agcctctcat gatggcggaa 2142481 agtgtaccgg cgccgccgca ctcttcatct acaacactct gaaacaatac atctcccttc 2142541 agtttgacat cgcaggcgtg cagggcttct aaagcaaaaa gaagggctgt attgcctccc 2142601 ttcatatccg ttgagccgcg gccgtatatt ttaccgtttt cttcgacagc ttgatacggt 2142661 tcatacttcc aatcctttac gcttccttca ggcacaacat cgatatggcc gttcaaaatc 2142721 agggacctgc ctccgccggc tcccgttttt ttagccacga tattcgggct ctcatgaaaa 2142781 tcggatcggt tagatttaaa gtagggatgc tgttttaatt gctttatgct tggctcccat 2142841 acatcaatgt ccatatgaaa ttgccgcagc ttttcaagca caacagcttg ggcgttaaac 2142901 tctgacccca atgtgctttt ttccccaatc agccttttga gaagacgaat ggctttggcc 2142961 gaatgctgat caagccactc gattactttt ctttcaatgt cttgcatcct cattccccct 2143021 cttaagaaaa aggcatatct attttgattt cagcttctgt cagcctcgtc acctcatcga 2143081 ttgtcgagcc attcatcagc tcttttaaaa tgaagtgatg gctatcgacc tcaagaaccg 2143141 ctttttcggt aataatcaaa tctacacagc ctgcagcagt taatggcagc gtacatcttt 2143201 ctgttaattt aggccttccc ttttgatctg tatgactcat gacgacaacc acttttttcg 2143261 ctttttgggc aagctccatc gccccgccca taccaggcac cttttttccc ggaacaagcc 2143321 aatttgccaa atctcctgat tggctcacct gcagggcgcc taaaatcgta atgtcaattt 2143381 tgccttttct gatcatcgca aaagacatgg ttgtatcaaa ataagaagcc ccttttacag 2143441 cgcggacagg atatcccgcg gcgttgcata aatgcgcatc ctcttctccc ttttcgggac 2143501 tttctccaat gccaaggaca ccgttttccg cttgaaacat gacctgcatg tcaggcttca 2143561 aaaagttcgg taccaaggaa gggataccga taccgagatt cacaatcatg ccctgcttaa 2143621 tttcagtagc agcgcgtttt gcaatctgtt ctctttctgc tactcccaag cccatttcca 2143681 cttcactccc tcgcttcgta caaccccctc aacaaaaacc cccggtgtga caatcatttc 2143741 ttcagaaatc tcccccatcg gaacgatacg ctcagcttcg gcaaaggttc tcctggcggc 2143801 cattgccata agcgggttca tattgcgcgc ggttttgtca tacgttagat tgccgaattc 2143861 atctgcaatg taagcattga tgaaagcaaa atcagcagtc agcgcctctt caatcaagta 2143921 tcgttttccc gccactgtta cgatgtcctt tttttcgcaa accatttgat tatcaatgcc 2143981 cacgtcggtt aaaataccgc caagccccgc tccgccggcg cgaatccgtt ccgcaagcgt 2144041 tccctgaggt gaaaattgaa cctctaacgt cccctctgtc atctgttttc cggctactgg 2144101 attggaaccg atatgcgagg cgatcagggt tttgacccgt tgattaacaa taagcgggcc 2144161 gattccgata tccgggaaac cggcgtcatt gcaaatcaca gtcaaatccg ttacaccgct 2144221 gtccaatatc gcttcaatca atgaaggagg cgacccgact cccccaaaac cgccaaacat 2144281 cagaaccgat ccatcccgaa catctgcaat tgctgtgtca atgctgattg ctttttgaaa 2144341 tggcgccatt taatgtcaat ccttttttaa gtttttttcg accgctgcaa ctgtttctga 2144401 aaaaatagag ataagctctt ccatttcacc gtctgaaata gtaaaaggag gagcaataat 2144461 gacagcatct ccttctccac tgtctattcc agctttggaa ggataaacaa tcagcccgcg 2144521 ttttttcgcc tcgctgacaa taagctgggt tatcgcctgc tctggcggaa acactttctt 2144581 cgttttttgg tctgccacaa attcaatgcc taatagcagt ccttttccgc gcacctcacc 2144641 tataatgccg ctttgagatg ccgcctcatc aagcttcttc ttcagcacag cgcccttttt 2144701 ttctgattgt ttgatcaagc cgtgctttaa cacatatcgc aaaacttcaa gagcagcttt 2144761 ggctgaatag ggatgtgcac tatatgtgtg accgctcata atcacacctg acccttgttt 2144821 tatggtttca ataatagaat cagatacgac ggcagcagca ataggtgcat accccgcacc 2144881 gagtcccttc cccagtacag caatatcagg tacggtatcc caatgctctg tcgcgagcat 2144941 ccttcctgtt ctcccaagcc ccgtcatcac ttcatctgca ataaaaagca catcgtgtgt 2145001 gcggcatacc tcacttaatc tctcataata tcccggaggc ggagtaatcg ctgctcctgc 2145061 agcaccaata ataggctcag ccacaaagcc ggcgatgaat tggcttccga ttcttttaat 2145121 catggtgtcc agttcatcag ctgcagtctg aacaaagtct tcttccgtct cgtgattcag 2145181 ccgataaata tgtggagctg agatagctgg ataccgctca atgagatggg tgaaccggta 2145241 tctcctttca taaaaaccag acaatgaaag cgctcccaaa gttattccgt ggtaactgct 2145301 ccatcgagac aaaaagatgg atttttgtgt ttgctttttt tcctgccaat actgaatggc 2145361 gattttcata gctgtttcta tcgcttctga tccgctgttg acaaaaaaag accaattcac 2145421 atctccgggc agctcctgtg ccaagagagc ggctaattgc tcggcgggct cactcgtaaa 2145481 ctgtgagcgg taagcaaaag acacctgatc aagctgttct ttcagcttct cagtcacatc 2145541 acgaactccg tggccgatat tacatgtcac cgcacctgac gagccgtcga gatatttttt 2145601 tccggtctga tcataaacat atgaaccctt cgcataactg acaaccggat aggccgagct 2145661 aagctctggc ttaatcaaat aactgctcat gctcccacct caaaacccct tttaccatat 2145721 tgtatgagtg tccaaatggc ggcatgacgt tccccgcaaa aactttttca cataaaaaga 2145781 gccttcctaa taaggaaggc tcttttgaaa tttcagcatc tagcaaataa aagcggctcc 2145841 aacaataatt aataaaatga acaagacaac aattaacaca aatgtatttg tcccgcagcc 2145901 aaatccgtaa ccgtacccag agtatccata catgctgttt tcatcctttc ttatcacgat 2145961 atacgacatt ttatgcgggc caagtcccaa atggtttgtg caaacgccta tttcatgtaa 2146021 ggaaataatg aaatacagta tgcacccgct catatttttt aaacgtcagc ttttcgtaaa 2146081 actgagttgc accgtcagtg cttgcagcca ctaagtaggc tgcttccatt cctagtgatt 2146141 tggcgatgga cagcatttct ttcactaaga tactgccgta gcccttcctt tgaaactgat 2146201 ctaaaattgc cacttcttcg attttagccg ttttctcttg atgatcgata aacagctcgc 2146261 cgcacccaat gggaactttc tgtgcctggt cgctgtaaca aacaacaaga atgattatat 2146321 ctgcttcata gaaaggatat tttcttttta atttttgttc agcgattgct tctccaatat 2146381 aaatggaatc gtaaattttc ataatagaag atccgtcgct aagacttttt gccgtccccc 2146441 atgcggttaa aggatgtccc atctgcccct tccagtcact aagcttcatg tcatatagta 2146501 gctcatcctc gacgacaaaa ccgcttttta caagtgactg cttcaaaccg agcggaaaaa 2146561 catgctgcgg cgacgctttt aaatggagat aattcgcatc aagcagcttt ggtacggagg 2146621 gtaaaaagtt aagtaaccgc tccaatggaa acgtatcatg gagctgaaca aagttatgag 2146681 aaaaaatttg cggaagctgc ggatctctgt atacgctgta atgatcaaac gatgccgatt 2146741 cagacgttaa caatatatat tgatgttccg tttttgaata atgtcctgtc atgaacgtct 2146801 cctttttatg acctatacct ttactctgtt gcaatattca atttctttat aatctcatcg 2146861 tacaccggat aaaacggctt tccaattgga aattgctgaa tatttcggaa agaagcggag 2146921 attggcttct gatgtaaaaa aaacttcctt gttacttgtt cactaatcgg gtgaaagacg 2146981 ccgtttagaa acaaaaacgg ctcgcgttcg atgaaaaaca gacgtcggcc aggcggattt 2147041 ttgatcaatt cagatcgttt ccacgtaatc ggcggccctt ccggaagcgt ctccatctct 2147101 tcttttccaa ttgtcactat gtcttttctt tgaaattgat aaaattgaaa cgcatactgg 2147161 tccacaattc gccttttttt tccggcttcg atataaaata ttgcaggatg gtcagcttcc 2147221 tttactaaaa tataattcgg aatgtttaaa attttgccaa tcctatattg gaataaatat 2147281 gggtctggaa cagcgacagt ccgatttaga tacaaaaaac cccacttttc tccaacagga 2147341 tgccttacac cctgatcaaa aaaatacaca ttttgatctg aaccttttac aaaagagccg 2147401 tcaatcaaat cggcgggcag aaaccgatat gcattttgaa atgaatctgg ggttttatag 2147461 gttgtgtcta atacttcatt tatcggcaga aatggggtaa agttgttgag tctcgcccaa 2147521 aaaattgcgt cgccatgatt ccaatgcttc atatcatcat cccagtagcc tccaaattta 2147581 tggtgaatga gattaagtaa cgaacggcga tgcataactg agcaatgatc aacttgaaaa 2147641 gcggcctgat caagcactgc attggcattt ctgtagaaat gtgagatttc ctctcccctt 2147701 tcgtttacat gtacaacttt ttgttttgaa tagaccgcct gcgcttcagg cttatgtgaa 2147761 aactcttgca ccatacggct cagccgctca ggatgataaa cagtgtcgtc agtaagatag 2147821 gaaatgtaat cgccgtctgc aaatgggagc gcactgttaa ttaatgtggc ataacgggct 2147881 gtttttaatc gatctgcagg atgcacgaaa ctgttatgat attgaatgcg ccggtcatgg 2147941 agatacttgt gaatcaccgc agttgtttct gcattcgaat gatcatccat gataaaaagc 2148001 tcccaaagat catgcgtttg ctgtatcacg ctttcgatcg ctttttgcaa ataatcgggt 2148061 ttgttgtaac ttgttaaaat aatagacact ttctctccca tctataccgc ctcccgccgt 2148121 caaacataaa aacggctccg cagcaagcag agcctctgtc atcatttaaa aagcacccca 2148181 gcttacaaca cttgagagtg aaacatgaga tctcgtgtta tttaacgggt tttggaaaat 2148241 aaccaaatca gtcagaactt cttttacgat gacattttga agtgtatctc cgttgatcaa 2148301 attgactttt gaaaccggta cgcccagctc ttttgcaaaa acaagctggc gtctgaggtc 2148361 agatggattt ccttcagaag acgattgacg tatcagcaga atcagcaaaa gcaaaataaa 2148421 atgcagatca tcttggtttt cttctcgatc cacttgtttc tctaaatcca aatcatccct 2148481 ctcccttatc cttatctctg tttcacaata tgtgcgactt cgatttatgg tataggctat 2148541 gtccactcca ttaaaaaatc agcattttcc ttaaatagat gaaaaataga tcaggtacgg 2148601 cgttcgactc ataccaaata acagccggaa gaatatgaat aacgtgagtt cactatcgaa 2148661 taggaggtgt gtgtaatgag ctctgaaaat gcacagttaa aaaaggattt aattaaagcc 2148721 gttttaagcc ctttatttcc aactgcaaca gaaggaggag aaaatatgga tagtaatctt 2148781 aaagccttgc ttgatgctgc catcgatcaa aaagtagatg aaagtgaaac ggttacggca 2148841 gaatctattt tagacccttc tcttccggca agatggattt ttgccagaat tacgccaggc 2148901 actacaatca gcattgtgac tgattcaggt gacatgatcg gaccggttgt tttcgttgct 2148961 ttcgatcagg ttcacgggat cgtatttgta acacaggaaa gctccgtcac tccggcaggc 2149021 caagctacaa cattaattga tgtagacaaa gtagaaagcg ttacgttctt ttcataacat 2149081 ccgatgaaag tcttgtatat ccagtcggga tacggaggaa tatacagtta ttttgatcgc 2149141 tgggctgaag aatgttttca gaacactcat acagagtata tgattgcaga taaacctgaa 2149201 gcagaatctt tgatgaagat cgaagcgttt cagccggatt tcacacttat gatggttgga 2149261 gaccgcgttc ctcacgactg gctgacctgg ttaaagggta aggatatccc cgtgtatgtt 2149321 tggctgaccg aagacccatt ttatatggat atcagccttc aggtaattaa gcttgctgac 2149381 gccatattaa cgatagaaca aaatgcagct ctctactatc aagagctcgg ctaccagaac 2149441 gtctattatg ttccgatacc agttaaccat cggctgttta aaaaaatggg caccgaacat 2149501 tcctatcatt caaatctgtt aatcatcggc tatccttacc ctaatcgggt tcagcttatg 2149561 aaagaagcgg tccatctgcc attcacggtt cgggtaatcg gcaaggaatg gggaaaatat 2149621 ctgcctaaaa aagtgctcaa acagccgcat attgatgtcg tcagcacatg ggttccaccc 2149681 gaacaggccg ttcattatta taatggggca gacatcgtaa ttaatgcgca tcgtccctat 2149741 cattttgctt tcaaccaaaa tactatgcgc atcaaaaatg ccagttttaa taaccgaacg 2149801 tttgatatcg ctgcatgcga agcatttcaa ttaacagatt tacccgcggc gcatcctttt 2149861 tcatccatta tttcttatca cggcatgaac gactttaagg aaaaagccgc tttctatatc 2149921 aaccaccctg aagaacggca aaaagctgca gcagccaatt ataaagagac cgtacccgca 2149981 tttacgtttg atgagcttcc tgcaaaacta aaagcgattc atctggcgct ttcttgaaaa 2150041 atcgttcatt gctatgaacg atttttttat tcatagaaaa aagcagctgc acaagctgct 2150101 ttctattcta gccgtcagaa cggtctttca gcttcctcgg atttacctgt ttatgaagat 2150161 caggcatttc gccgagatgc tgtgcaattt gttcccacga tacaattttg aaattttgat 2150221 tgacggcttg tccgttatca atattttcgc cgtcctgcgc cacaaaaatc ccgtacggat 2150281 attttgggcc aagtccgaaa ccgagaacat caataccatc cgtgtcacta gtaccgtcta 2150341 tcttctcgcc atctgtaatc tcaaagttgg ctacatagcg atttttcccc tgccgttcat 2150401 acattgcata gctgttattt ccttgacttg aagccatgag atatcctttg ccatttggtg 2150461 cataatagat tgtcagtcct tcaatatcag ctgtcaaatg atctcctgtc gcacggtcaa 2150521 caacctgccc ctttgaccct ccgccgggct cagcgttaaa tttccagatg gcctcatctt 2150581 cctctgctat gtataggttt ccgtactcat catccgcaac aaggccttcg gtctgagaat 2150641 tcaacttaaa ttcacgcacc tttttccctg ttacataacc ctttccacca tcaacaattt 2150701 catactgctc aaattcccct tgtttgcctg tcactaatgc gtaaaatgct cctgttttct 2150761 ggctgtgata caagctgaat ccataaacct cagaaatatt ggtggaaata ggatggttcg 2150821 gatctgtaat gcttttcaat tttcctttat ccccgtctat tgcatatact tcaattgtat 2150881 tttttccttc ggaccggttg gatgcggcag caatatcaat tttttcgccg ttcaatggaa 2150941 aatcatagcg cagatcgaca ttattgagct tgccaaactc ataagaatga agctgttttc 2151001 cgtctaaatc atacacaacg agccctgact tcttatttgt tgtaatcaac ttgctttttt 2151061 ccgggtgttt ttcatgaacc caaatggccg ggtcatctgc tgcatcatcg ccagatgcga 2151121 ccggatctgt ctccgtgtgt gcagtcactt tgaaatgatg ttcctcattc acataatgag 2151181 ccgacaccga ggttgctgtc aggctaagca ataaacccgc ggcagtgctt agcagcattg 2151241 tttttggaac cttcatttgg taccctcctc ttttatcact aacactacta ttgtaaaata 2151301 tatacaggtg attaccgtga ggaaaatgaa ccttttttta tagggtttct gactcataaa 2151361 caacttattc cccaaagagg tggtgagatg actttgccag atttactttt gcggagcgaa 2151421 ataaaaatat gttgaatatt tagtacatta tttatttagt tttgtttttc cctagttacg 2151481 tccgtttttc cattttctat taaaaaagaa cactttgtga catgatcatt cccctaaatt 2151541 ttgttttatt ggttgctttc attaattcga ttacaaagtt gaacatatga tgcatggtag 2151601 agaaacgaga gttggaggat aagccatgcc taaacagcaa acagcagaac taaaaccatt 2151661 tttccataac aaaacagttt tagtcactgg cggaacgggt tcaatcggga gtcaaattgt 2151721 caaacgcctt ttgatgctta cacctaaaca ggtgattgta ttcagcaaag acgacagtaa 2151781 acagtatgtc atgagccaaa agtatgcgga ggataagcgg ctattatttg tacttggaga 2151841 tgtacgcgat cacagaaggg tgaatcaggt gatgaaaggc gtcgatatcg tctttcacgc 2151901 ggctgcgctg aaacaggttc cgacatgtga ggaccatcca tttgaagcga tccagaccaa 2151961 tctcatcggc ggacaaaatg tggtggaagc tgccctttca caccgagtgc agcatgtcat 2152021 taatatcagt acagataaag ctgtatctcc tgtgaacaca atgggtgcca ccaagctgtt 2152081 atctgaaaag ctgtttcatc aagcaaaccg ccacgtccaa aacaaaggaa ccttgttttg 2152141 ttcggtccgc tttggaaatg ttctcggttc cagaggttcg gtcatcccca tattatttga 2152201 acagatgatg gagggtgaac ctctgaccat cacagacaaa aacatgacca gatttttcat 2152261 gtcaatagac gatgcagcta cattgacatt acaatcggct gctattacaa aaggcggaga 2152321 aacctttatt ttcaaaatgg aatcactgaa acttgaagaa ctgattcatg ggtttgaaga 2152381 atatgcatcg cagcacgggc tcccgcggcc ggctgcagta gaagtgggca agcgtccagg 2152441 tgaaaagctt cacgaagaat taacatctcc acatgaaatt gaatcactgt atgaatgggg 2152501 caacctttat gcgatccttc cagagccgga aaaacatcct gactttcgca aagtcaatct 2152561 gcctgggtat caatcagatc aagccccgct cattacgaaa gaaagaattg ctcagattat 2152621 tgaagaattg catcaagaga aaaaggcata aaaacaagcc tgtctatcca ttaggcaggc 2152681 ctgtttttaa cagtttattt attaaagaga tgcagatagc tttcgtatcc ttcttctttt 2152741 agcttatgct tcggaacaaa ccgcagcgct gctgaattta tgcagtaacg aagtccgttt 2152801 ggccccggtc cgtcattaaa tacgtggcca agatgagaat cagcagttcg gcttcttact 2152861 tctgtgcgaa tcatgccgtg gctcgtgtcc agtttttctt ccacttcttc ttcaatcggc 2152921 tttgtaaagc ttggccagcc gcattgggaa tcaaatttat ctttggatgt aaacaatggc 2152981 ttgcctgaca caatgtctac atacaaccct tcttccttat gatcccaata ttcattttga 2153041 aatggcggct ccgtgccgtt attttgcgtt acttcatatt gcatgcgatt taatgacttt 2153101 attttttctt ctttattgta cgccatttat ttagcccccc aatgctcgct gataaatccc 2153161 gctcgtccgg aacctgtccg gtagcgctga taatgtgctg gattcttttt ataaaaatgc 2153221 tgatggtagc cttccgcttc atagaaaggt tcagctttta aaatgtccgt tacaatcgga 2153281 tctttaaaga tgccgctttc cgccagacgt tgcttggaag cttccgcaag ctccttttgt 2153341 ttatcattat gataaaaaat ggctgcgcga taggaactgc cgcgatcagc aaattgccct 2153401 ccggcatctg tcggatcgat ttgctgccaa aataattcaa gcagtttttc ataagggaat 2153461 acatcaggat gaaacgtgat ttgaacggct tcacgatgtc ccgtcgtttc actgcacacc 2153521 tcttcgtacg tagggttttc agtatggccg cctgtatacc cggacaccac tttttcaatt 2153581 cccggctgtt cgtcaaaagg tttaaccata caccaaaaac agcctcctgc aaatgtggcg 2153641 atttcttttt tttcagacat actggtgcct cctttgttaa tacgtggtat tattatatta 2153701 tagcatgtaa aaatagaatg aaaatgattc tgcttttcaa taaaatctat aggttttaag 2153761 caatatgctt atgtaatgga ggttcacaaa tttgaaagta agaacacaga tgatgtacga 2153821 tatggaaact ttactccgta aagtctttaa acaaatacgc aatgaaatca atgaaatttt 2153881 agataaagag ctgtcgcgga atgaattcac cattcttcga atccttagtg aacaagggcc 2153941 taaaaaagtc actgaatttg cgcctatttt agaggtatcg gcaagccaca ttacggctgt 2154001 gaccgatgcg ctggtagaaa aggaatggat tacgagaatc agatcgaagg aagacagacg 2154061 catcatccgc attcatatca ctgaagcggg cgaaaaagtc cttcagcact ttaacgagaa 2154121 aaaaacggaa tatttcttta aacgctttga ctgctacact gatgctgaac ttgccacgtt 2154181 aatcgagctc ttcagcaaac ttgataaaaa acggtgaaaa aaagcacata ccgatatata 2154241 ggtatgtgct tttcgcagtg cttcacttat ttttcagtaa acagcttcat tgctttccag 2154301 cggccatatc tataatacaa aaatgccgcg cagctgctaa ataaaaaact cattccgatt 2154361 ccaagcccga ttcctttttg tccaagccaa gctgaaaata gagctgtgaa aggatacctc 2154421 aacacccaaa acgagatcaa atttaatacc agaacctgca gcatcgctcc cgcggccctg 2154481 acgattccgt tcagcacaaa attaacccca ataaaagggt agaaaaacgc gatccacttc 2154541 aaatattgtt caccaaatgc gaccgcatca ggctcactga taaataacct tatgaggtat 2154601 ttaccaaata cccaaatcat aaccgcaatc accagcatgc aggaaataac agctatcaca 2154661 cctagccttg caattgttcc cactcttttt tcgtttccga ttccaatatt ttgccctgcc 2154721 atactattga cggccgtacc ggcagccatt gctggaagcg tgatgatgct atcaagccgc 2154781 tgcaccgcgc caaagcctga taccacgtga tccccgtatg agttaacaac actcataatc 2154841 gccatcatac cgcctgtaat caccatcatc tgcagacctg ccggaatccc gagtttcaaa 2154901 atcagcgcgg actcttccca cttgggcatt ctcggaatcg agaatggcac aagcttgtgt 2154961 ttgatgacat aaaacaaccc atacaaaaac gcaatgccct gtgacaaaat cgttgaataa 2155021 gccgctcccg ctattcccat gcggaacaca gaaataaaga gcggcgcaag cactgtattc 2155081 agtacaacag caaacgcaat aaaccggaga ggtgtcttgc tgtcgcccag cgcacgaagc 2155141 acagtactga taaagttata accaaacaaa aataaaatgc cgataaattg aatctgtaaa 2155201 tacgtctcag caagcggtat cattgactcc ggcgttttta gaagacgcag caaaagctct 2155261 gagagaaaaa aaccggccgc gccgaatccg atgcttaggc ctgttaataa aacaacaaaa 2155321 gcgttaatat acgacgccat tccttttata tcatcttttc ctttttgctg agataaaatg 2155381 gttaacgtcg cattgttaag gcccaaaata aaagacagca cggtcaaaac aatcgtgctt 2155441 gataccgcgg ctgccccaag ggcctttgcc cccagtaaat tgccgatcca caagctgtct 2155501 ataaattgaa aggaaacctg caatgcgttt ccgagcataa taggcattga aaacagtaca 2155561 agctgtttca gcacgttccc ctgtgtaaaa tcgtatgctt tcatcttttc tccttgtgtt 2155621 ctcaaatttt cttcggacca cacgaaaaaa gagacgttgt ttcatgtctc ttttttcatg 2155681 acttatcggt tttttttcgg tctcgcatac cgaatgtaaa caccatcaca cttaggaaca 2155741 aggcacaata ggaaacattc aaatacattt gatccatatc ttcagcagcc agatgatgat 2155801 aagcaagcca gccgaagtac agggaaaatg taaaggataa taaactgaaa tactggtaaa 2155861 tccgtttcat tttcagtcac ctctattgtt taggatggta ataggaaaac tcaatttcat 2155921 ctttttctaa atttatctta tccgctttga catacattcc attcgttaaa ggcatttctg 2155981 acaaacgcac ttcaatgctt ttatctccgg ggtgaacatg gacaaatgac ggcaattcat 2156041 aaaagctgtc catataattt aacacaaagc taattggtat actcaatttc cctaacgaaa 2156101 atttcgtgac attcagctct acatcaccgt tttttttcac ggtcggctca aaagcgataa 2156161 acgcatcaat agacgtggaa aatgccttga ttttccctgc gacatgaaca tcatcatcaa 2156221 tctctacttt ataatcaagc ttgtttgatg ctttgtcgtt taaatatgag ttaacaaacg 2156281 cagctaatga ttcttttgtg cttgtcactt gaaatccata ctcgctctca gatgcatctt 2156341 tcacctgagc ctgttccccc ggaagcaaaa caagtgccac aaacccggcg gcgaggataa 2156401 aattgattgc aagcaatata aaaaacagtc gcttccactt attcatgctg tcaccctact 2156461 ctttcggtaa tccttctttt ttaatggctt gatagacgcg ctttgcgata agagaataac 2156521 ccgtaccatt aggatgaaaa tcatcttcct cagaaattcg gctgctgtca cttttttgat 2156581 taaacaaatc ttcgatatgg acgatttttg catgtttatc ttttttcagc tctttttcag 2156641 caatatggtt ccaatccgtg acgacaccat ttatttcatt tagttctgat aatgtaaacg 2156701 taaacggatt gtacatgctg acataaatca gctcagcgtg atcattcagc tcgcgaattt 2156761 cagaaatgat tttttcaaag cgcttttcgt acggtttttc cgcttcctga aacggttcaa 2156821 cggttaattg cagaaagttt tggcgaagga ttttcatcaa atcattaccg ccaattgtaa 2156881 aaaagacata atctgcgtcc tttatgcctt tttgaacctt tttatctttt agtttttcta 2156941 ataaatcatc cgaacggttc ccttttacag cataattttt cacgtcgacc gttttgactt 2157001 gtttatctga ccggatagaa tccgccacct tgccgacata tccctttccg tcgggatctc 2157061 cgactccttc tgtcagcgaa tctccgacag ccgctatgac aatgtgttct tttgttttcg 2157121 tttcatgggc tttttgtttt ccctcagatg atgtacgtat gctcgtacac gcagtaagaa 2157181 gcaaaatcaa actggccatg attgaaaaaa tgcgcagctt caatcttgtt gctccttccc 2157241 attctactag tggaaagtgt atcatgtttt agaagatttg caaatgccta gtctcttagc 2157301 ttacttgagt gtactggctg acttcacatc ggaaatgata tcatcgtacg gtgtattctc 2157361 cactccattg taatctttca gcaccttacc gtccggacct accaaataaa aagaagattg 2157421 atgaatcact tggtcctctc cctccggctt ctttacgatc gctttaaagc tcttaagtgc 2157481 gaactcctca atctcactct ggctgtatcc cgtgagaaaa tcccagttat caaaagataa 2157541 tggataattt gcggcaaatt tcttcagctg tttcggctta tcgttttctg gatcaacact 2157601 aaatgatatg atgcggacat ctatattttc ggctttcagt tttttttgca gatcggtcat 2157661 atgagcggtc attggcggac atatagtttc acaattggta aaaataaaat ccgccagcca 2157721 tacttctcct tttaaactct ctaaagaaac gttcttgccg tcttggtttt gaaatgtaaa 2157781 aggctccacc tcgtaattga gcggatcttt aatctgctgt cctccgcatg cacacaaaaa 2157841 cagaaaaatc agcccagccg ttaacccctt gataaccttc atgacatcca tcctttccag 2157901 ccagcataaa aacgctttct aaaaccgtcc ttactgtccc atgtttgtat tcgatactga 2157961 gcaaaaaaaa tcctgcatgc ctccccatta acgattacaa aggagggcat gcaggtaaaa 2158021 aacggcatgt tacgcgttgt gctttaacac ctcttgatga aatacagcct gataatctgc 2158081 ccacttcatc cgccgcttca tataatgtcg gaaagaatac acttttgccc tgctgtttga 2158141 tgaaaacact tcttttaagt agaattgcaa atggtgatgt aacataaaga aatagtgctc 2158201 atcttccttt aatacaggta tttctgtcac tttcacctga atcccgtcac cgcgtttgaa 2158261 ctctaggctt ttgagtaaca agctatcaat cctctttttt gtttttcttc tattatatat 2158321 gatgccagcc gggctgtctg tcattttgcg cggttgtgta aaaaaattag attagcaaat 2158381 ggaacaagtc ctcatccttg ttcacctcta cataatgaaa cggttttttg ttcatccgtt 2158441 caatcagcgg cccataatcg gctttgttct gcagctcgat gccgacaaga gcaggtccat 2158501 tgcttttatt atttttcttc gtatattcaa accttgtaat gtcatcattc ggcccgagga 2158561 cttcgtcaag aaattcgcgg agcgcccccg ctctttgtgg aaaattgacg ataaaataat 2158621 gctgaaggcc ttcaaaaatc aaggaacgct ccttcatttc ctgcattctt ccgatatcgt 2158681 tattgccccc gcttaccaca cacaccacgt ttttcccttt aatttgatcc ttgtacaaat 2158741 caagcgctgc gacagaaaga gctccagccg gttcagcaac aaccgcacat tcgttatata 2158801 attcaagaat ggatgtacat acttttcctt caggcacaag gagaatgtca tcaacgacag 2158861 tttccagcgt ccggaaggtt tcctcgccaa tttttttaac agccgcccca tctacaaact 2158921 tatcaatttt atcaagtgtg acgacatgcc cagctttgtt tgattcaaag taggatgccg 2158981 ctcccgccgg ctcaacagca attacctttg tatcaggaga cacgtttttc aaatatgtac 2159041 ctaccccaga gagaaggccg ccgcctccga cacttgcaaa aagaaaatgc ggttctgtat 2159101 caatgtcgtt taaaatctcg actgcgagcg ttccctgtcc ggccatcaca tccggatcat 2159161 cgaacggatg gataaacgtc cgagattccg cctcacagca ttcagcagcg cttttatacg 2159221 cgtcgtcaaa cgtatcgcct gtcaaaataa tatcgataaa tccttttccg aatagttcaa 2159281 cttgagatac tttttgtctc ggtgtagtag acggcataaa aattttcccg tgaatgccaa 2159341 gatgtttaca cgaaaatgcc acaccttgag cgtggtttcc ggcacttgca cacacaactc 2159401 cgttctctgt ctgctcgctg gaaagctgtt tcattttatg ataagcccct ctgagcttaa 2159461 aagatctgac aacttgcaag tcttcgcgtt ttaaatagat attgcattca tatctctcag 2159521 aaagtctgtc attcctctgc aaaggtgtgt gaatgacaac gtcctttacg ttttggtgag 2159581 ccttcaaaat gtctttcact tggatgagag agttttcttt aagcaacggt ttcatgtaca 2159641 gattcctttc ttgttttaaa tccctattta atatgccatt ataacatgaa tattcaaaaa 2159701 ataagacaat tatttttatt taataattaa aaaaatacag actatgtcca ccacatcttg 2159761 tggtaacttc tgttcaacca ttatcctgca gagccaagaa aaaagatgat cgtaaaataa 2159821 agggtgtttt caaccaaaag gcatgatata atgaaaccaa ttagaaccaa aaggagccaa 2159881 ttgatgaata gtgcaccaaa actcaataca tttcaacatc taatcggaga acatcaaact 2159941 tttctggaag cgaagcgaat cgccaagcag ttctcgttat cggagcttcc tgtcttaata 2160001 acaggaaaaa tcggaacagg caaaaatcac ttcgcacatg ccatacactt ggaatcttcg 2160061 agaagcaatg aaccgtttat aagcgtcaat tgcagcaccc attcggaaga aacccttatt 2160121 catgagcttt ttggccctaa cggaaacaca ggtgtttttc aaaaagcggt acgaggaacc 2160181 ctttttcttg atgatgtatg gcgcatgcct gcttctgtac aagctcagct gttaaaagcg 2160241 cttgattcag acacggagaa accgcgaatg atctgtgctt ctgcagaccg atccgtggaa 2160301 catacattca ggcaagactt attctacaga ctgaacattt taacgctcac actgcccgaa 2160361 ttatcggaac gaaaaagcga tattccgctt ttgacacagc attttctctc aaattctggt 2160421 cagcaattgt taatcgatcc ctccgttttt cccgtgcttg agaagcatgc atttgaaggc 2160481 aatgtcaggg aattaaaaaa cgctgcagat tatatggcgg cagtatcaag cgggggaacg 2160541 attcagccat atgacctgcc gccgtatatt agaggcacga tagacggaaa aacgtcgaag 2160601 aaaaaagcga aactgcttac tttaatggaa aaagctgagt ttttgtttat tttggaaaca 2160661 ataaaagtat tgaacgaaaa aggagaacct gccagcagac ggatcatttc tgaacacagc 2160721 aaaaataccc aaacctcgtt aactcctcag caggtcagaa gccgtctcga ctatttggag 2160781 aaaaaagatt atgtcaccaa aagccgcgga cgcgcaggca caaaaattac ctttgagggc 2160841 ttgagcttta tagagacgtt aaaaaatcaa atgatctagc gatcgaaagg agaatgtact 2160901 tgtttacaat caaagaagag atcgccaatg cgattacaca cggcatcggt gtcctcttat 2160961 ccatcccagc attagtgttt ctaatcatat ttgcggctaa ttacgggtct gcatgggaca 2161021 ttgtcagctt tacaatattc ggtgtctcta tgctgctgtt atatttgagc tccaccctgc 2161081 ttcacagcat cacacataaa aaaacgaagg acattttgga gattattgat catagcgcaa 2161141 tttacgtact catcgccgga acctacacgc cttttttgct tgggccgctg aaaggcacac 2161201 tcggctttac cctgttggtt atcgtatggt cacttgccct aggcggaatc gtttttaaaa 2161261 ttttctttgt gaaacggttt atcctattgt caaccttcgt gtatttagtc atggggtggc 2161321 tgatgattat tgcagttaaa cctttatatg cttcactgag cggagcggga ttcagcctcc 2161381 tttttctcgg cggcatttta tactctgtcg gaaccatctt ttacatttgg aaaaagatcc 2161441 ccttccatca cgccatttgg cacagctttg tattgggcgg gagcgctgcc atgtttttct 2161501 gcgtgctctt ctattgtgta aaggtgcctt tcctttcgta acagtaacag aaaagcgcag 2161561 tcttcacgac tgcgcttttt tatgcacgta attgtttttc attggcaggt atataagctt 2161621 ttgaaaagga caattcaatg tctgccggtt ttaagcgttt aaaaaacgag ccattttgca 2161681 tgttatctgt tcctttcgtt tccaccatca ccaacggaag atgatagcgg gccgcaagtt 2161741 ctacaggatc aatagaacca tctagtgaaa gaatcaggct ttgtcccttt tccagctgtt 2161801 ttgtcacatc ttcatatacc ttttctgaat ccccgtctga aatcacatcc atccgatcca 2161861 gccattgccc gataaaaggc aagcggaaca cttttgggtt agcgataaag ccggccggtt 2161921 cctcaatata tccagcaatt aaggccagtt cagccaaacg caaacgggga tgcacataca 2161981 aaacaggacc gtgtggtatt ggctctggct gatggatcgt cacaactgaa ccggagatgc 2162041 cgatacagcc ttctaaaaac gcctttggct gttcgtacac aagagccatc tgttttttgt 2162101 atgacagacg gggatcgagc attgtttgat taaataattg tttcatattt tttaacagca 2162161 tatacacaat ataaaccact agaaggctgt agcgaaccaa ttaaaatcct cccgctttag 2162221 aagaattctt tttttcatac attagaaatt cgtaatcata cgggtttttt tcgtctttgg 2162281 tcccctgctc agaagaaacc agcttccaat tggattcatc aaattcagga aagtgacggt 2162341 caccctcaaa ctcgtgatga attttcgtca tatacagtct gtccgcataa gggaacaggt 2162401 ccgtatagag ctgagcccct ccgatcacaa agcattcttc agggcctgaa caaatgtcca 2162461 gtacatcctt taatgaactg acaaccgtgc atccctgaaa ttctgaatcc ggcgctgagg 2162521 taacgacaat atttttccga tttggaagcg gacgtccgat cgattcaaat gttttccggc 2162581 ccataatgat tgaatggccc gatgttattt tcttaaagta tgcaagatca ttgggcaaat 2162641 gccacggcaa atcattgtct ttgccgataa gcctgttggc atccatcgca aaaatgaatg 2162701 aaatcatacg ctgaccgccc cttttatatg aggatgcgga tcataatcct cgatgataaa 2162761 gtcctcaaat gcaaagttaa aaatagaatc aacctttctg gcgaaacgaa gctgcggaag 2162821 cggtctaaca tctctttcca gctgcaaatt gacttgttca atatgatttt ggtaaatatg 2162881 aacatcacca aacgtatgga tgaactcgcc cggttcaagc ccagtcacat gagcaatgat 2162941 catggttagg agggcataag atgcaatatt aaacggcaca cctaagaaaa catcggcaga 2163001 gcgctgatac agctgacagg acagcttgcc gtcagacaca tagaattgga acaggcaatg 2163061 gcacggcggc aacgccattt tatcaatttc accaacattc caggcgctga cgattaagcg 2163121 tctggagttc ggatttgttt taatatcttc aataagacgg gaaatttgat caatggtttc 2163181 tccatcagct ccccgccaag aacgccattg ggagccatat acaggtccaa gttcaccgtt 2163241 ttcatcagcc cactcattcc agattcgcac tccgttttcc tgcagatagc gtacattcgt 2163301 atctcctttt aagaaccaca gcagttcatg cgcaattgat ttaaagtgga gttttttagt 2163361 ggtgagcatc ggaaagcctt cccgtaaatt aaatctcatt tgatatccga aagtgctgat 2163421 tgttccggtc ccagtccggt ctcccttttt ctcaccatgc tctaaaacat gtctgcagaa 2163481 atccttatac tgtttcattt ttttcatcct ttaaaagtag tcttctagta gtgtaacaca 2163541 ataaaaaatc atttctgaac ccagaaatga tttttttata gtcagctgac gacaggcttt 2163601 tcatcctgtt ctttttcttc atcttgcaga tcctgatgcg tatgtgcaat tctgctcgcc 2163661 gctgctgcag caagagctgc cacaatatca tccaaaaagg tgtgaatacc gtctggactt 2163721 tcatcaagtt ccttaataat tccaatcttc tctttatcca aataaccgaa attggtcaaa 2163781 ccgatcgacc cgtacacatt aacgattgaa agcgggataa tttcatctat gccgtaaagc 2163841 ggttcatccg tttcaacaag gtgctgcagc ggttcgggga gaagtttctg ttctgcaagc 2163901 tgatcgagtg caaggcctgt caaaacagca tgaataattt cacgtttgtt caggactttt 2163961 tctacattct ccatgcaaac actgagcggc agatttggat tgtatttttc ctgaagtttt 2164021 tgaacaatcc gtgcaatatc ttctatcata acgccccgtt tgttcagcat atcctttgtt 2164081 atatcgacca tttcattcat tgtgtacttt ttcatgtcta atggcatctc ctttaggcac 2164141 tcatccagtt gggaggcgtg ttgcggtccc agtaaatgct cccaagctca tgatgtgatt 2164201 gaaatccatc ttctgctgta tgataatgaa aattaaacca gtagccgtca tgaggcgggt 2164261 ggtctcttcg cacatggaat ctgagaagat cttctccagt tgtccgattg taaacgttga 2164321 aaattttttc cgttttgccc gctgaaggca tgcttgagat cacaacatct tggtacgcct 2164381 catcatcttg caatgtcgct aaataatcac taatcacatt ttcgattttt ggcaggatct 2164441 ctttccgata gtcatcctca atgacaggag cgattctgct gccgaatttt aaaaaggact 2164501 gatcctcagc gctgtcaagg agctgttcct tgtacgattg aaaaagcagt tcaggatctc 2164561 gcctgtcatc cgactcatca tcgtacaggt catgctcatc ataaaaagcg gtgtaatcat 2164621 tctgctcaag actgctcggc tgtccggaag gcttgtccgc cataagggca gccggaggag 2164681 atacgagccc gaacgttaca atggtaaata aaaccacaag ggtctttctc atccacaatt 2164741 tcatgactgc ttattcctct ctattttatt gtcatgtttc tcttatttta gcacatccaa 2164801 aacatgcaag tcatgtacta tatgaaactg atatgcaaat taggagattc gttgctatgc 2164861 actttgtgta aaaacgctta caatatttca tgaaaggagg ctttccgcat gattgacgct 2164921 ctgtttgcca cagtttcact cttaacatta ttatactttg tcgtcatgga ggtcaccgat 2164981 taacagaaag cccgtgatat gaatcacggg cttgtttgaa tgacgccata atggaacagt 2165041 gctgtttttc ttttcatgac gttaaaacca aactgttcaa accgcgggct tttccagtgg 2165101 tcttttagca caacgctttt tctggcgact cgtaccgctt cattgataca tccttcgtgc 2165161 aaaacggaat cctctgccaa atcacgtaaa ggcgcgatgc cgtcagaggt ttctacaggt 2165221 tcatgaaaca ttggatcgaa ataaaccaca tcaacagagt tgtcagggag ctgcttgatg 2165281 tgttcaaagc aatcaccatt cttcacctgg attcttctca tcgcagcttg aagctcttct 2165341 atacccgttt cccatgaatg cagccccgtc ctcactaaaa cagacacaag atggtttttt 2165401 tcaatcccaa caacagaacc cgtttcgcct actgccatac ttgcgataat ggcatctgac 2165461 cccaacccga gtgtgcaatc taaaaacgta tccccttcag ataagccggc agcccgaagc 2165521 ataggttctt tctccccctg taagaagcgt ttggctctga acatcgctgt attcggatga 2165581 aaaaagaatt tggcaccttg tttcgtatac agctcaaacc gctctttgcc gaccacaagc 2165641 aaatcacgtt cagctgattt cagcaggtgc tcaaccgttt gtttattccg gccgcagtat 2165701 ggcatattta gctctttaga aagctgcttt gcagttttta tggtgtgttc agacggtcta 2165761 tagcttgttg ttatcatctt ctgtactccc aaaaagaaaa tgcccggaga acgggcattt 2165821 agcagtgcgc atcgaaggca gcagtcagat ttttcatgat ttcttccata tcgtgtcctt 2165881 caatttcatg acgcggaata aaatgtacga cttctttgcc tttcaaaaga gccattgatg 2165941 gtgaagaagg ctcctggcca gtaaaatact cacgcatttt cgcagtagct tctttatctt 2166001 ggcccgcaaa tacagtcacc gtattgtcag gtgttttgtc attctggagg actgcctgtg 2166061 tagccgcagg acgcgcaagg cctgccgcgc agccgcatac agagttaacg actacaagag 2166121 ttgtgccctc tgccttttcc ataaagtttt ctacttcttc cgctgttgtt aactcttcaa 2166181 aacctgctcc agtcagctcg cggcgcatcg gtacgacaag ctggcgcatg tattcttcat 2166241 aagccattga cataaaaaaa gccccctcta gtatccttca tctgaagtaa aggatactat 2166301 agagagggcc ggatttcaaa tgttcacgcc ttaaaataaa agaaagtgtc cccagctatc 2166361 tagattttca taataccgcc ggtgttggca cttgtcacaa gtttagaata acgtgccagg 2166421 tagccggttt tcactttcgg ttcaaaacct ttccagttcg cttttcgttt ttcccactct 2166481 tcttctggca cttgtacatc caagatgcgt ttttcaatat caacgataat atggtctccg 2166541 ttttcaacaa aggcaagcgg cccgccctca gcggcctcag gtgatacgtg gccgattgag 2166601 aggccacggg aggctccgga aaaacgtccg tccgtaatca atgccacttt tggcccgagt 2166661 cccattccaa cgatttggga tgttggcgcc agcatttccg gcatgccagg tccgcctttt 2166721 ggcccttcgt atctgatgat gacaacgtcg ccttctttta cttttcggtt gataatgccg 2166781 tcaagcgcct cgtcctgaga atcgaatacg acagccggcc cttcgtgtct tgtaatccca 2166841 ttctgtacgc cgcctgtttt aatgatagcg ccgtccggag ctagattacc gaataaaaca 2166901 gcaaggcctc ccttttcagt gaatggttga tccagcgggt gaatgacgtc ataatccttt 2166961 acttcatgtc cggcaatggt ttctccaaga gtttttcctg taacagtcag cgcatctaaa 2167021 tgaagcgctc cttctttctt cgaaagctca ttcagagccg ctgaaacgcc gcccgcttcg 2167081 tgaagatctt caataaacac atccgatgca ggcgccagct tagccaagtg cggcacgcgc 2167141 tcagcgactt cgttaatgcg ttctaaagag tattcaacgc cggcttcgtt tgcaagggca 2167201 agggtatgaa gaacggtatt tgtagaacct ccgagcgcca tatcgagtgc aaacgcgtta 2167261 tcaatcgctt ttactgtaac aatatcacgc ggtttgatat ctttgcgaat cgtttccatt 2167321 aattgcgcag ccgattttct cacaaactct ttgcgttccg gagatgttgc cagaatggtt 2167381 ccattacccg gcaaagcaag accaagtgct tctgacagac agttcattga gttcgccgta 2167441 aacatgcctg agcaagaccc gcacgttggg catccgaact gctctagttc ttgaagctcg 2167501 ttttcgttga ttttccctgc ttggtaggcg cctacccctt cgaatactga ggaaagggag 2167561 atttttcgcc cgtcacttgt tcttcctgcc gccatcggtc cgccgctgac aaaaatcgtc 2167621 ggaatgttga tgcgcattgc cgccataagc attcccggtg tgattttgtc gcagttcgga 2167681 atacagacca ttccgtcaaa ccagtgtgcg gatacaaccg tttccacaga gtctgcgata 2167741 atttcacggc ttggcagcga atatctcata ccgatatgcc ccattgcgat gccatcatct 2167801 accccaatgg tattaaattc aaacggaacg ccccctgctt ctctgattgc ttcttttacg 2167861 attttcccaa actcctgcaa gtgaacatga ccgggaacga tatcaatgta tgaattacac 2167921 accgcaataa acggcttgcc gaaatcctct tcttttaccc ctgctgcacg aagcaaactg 2167981 cggtgcggag ctctatcgat tccttgtgtg atcatattac tgcgtaattc tgccatggtg 2168041 atcctcctaa attctttcaa ttgtttgatt ggattttatt ttgacaattt tcagtttatt 2168101 tatgggctgt ttttgcaaat aagataaata caggccgccc tcaccttgtt ttgttctttc 2168161 gtgtttttat atttatatag ctttctttcg atttgaaccc tccaactatt aatattgtta 2168221 cttactataa atagttttcg gatatttttc aacaatattc gaaataattt ttataaaaag 2168281 tgaattcaca taaaaaaggt gcatgatctg cacctttttt atctttattc gccttttttt 2168341 ctgctttccg tcatttgttt ccaaacagaa ccttttgctt cttctccatg ctcaatacgt 2168401 tcaagcgcca ttttgacttg aaggctgacc tcaaattcgg ggtcatcttc ggcagcgcgc 2168461 aaagcttcaa ttgcactttc atcgccgact tcgtacagga acatggcggc acgccagcga 2168521 acaagcttgc tggagtcgct taatgacttg atcatagcag gaatggcttg aggatcgccg 2168581 atatcagaca ggcagtctcc ggccgttctt ctgactgata cagctttgtc ctcaagtgct 2168641 ttatacaata gaggaagaac atcaggtgtt tcaatcattc ctaagtacac aacagcctgt 2168701 cttctgatgg acacctttgg atcatccaat gccttctgta aaaccgggat atcctcttct 2168761 ttcggatcca tctgttccaa gtgtgcataa cgctttttcc agtcctcatc atccagcata 2168821 tcaagcgtta ctttatacgc tttgcgctgt acagcttgtt ttgcttcgcc ctttccttga 2168881 gcggctgctt cagtcagtcg tttcagccgt tcatcactgt atgccgcttg aagctcttct 2168941 gtcacatcat ggccgatttc atcaaagtca ccgaatctga caccttgttc tttccaagcc 2169001 cgctcaaaca caacattgga agcttcagat ctaagtttta agatcgcctg ctgaaagcgt 2169061 tcaggtaagc cgaagcgttc ttcccgctct ccatcggtta atttaacttg cataggaatg 2169121 ccgctgaaca tctgcacaaa aacttttacc tctccaaaag attcttgatc agaacgattt 2169181 tcttctgcgc tttcagcact ttccatccca aatgcagtgc ggacttgcgg taaaatgtct 2169241 ttccagtcgt atcttgcatt ccgttcaaca gcaagaaaat ctgcgacgtg atatacccct 2169301 ttaactccat ctattttaag gatttccgct ataacaagcg gtgcgccttc tgcttgctca 2169361 ggtttatagt tattgctttt gcccgccgga agctcttccg ttaagatgac tttcattgta 2169421 ttcgggcttg gtgtaggttc aattgatttt atcttcatga tcgtcctcct atagcatatc 2169481 tgtgacttat tctatcatag tcgctccaag ccttctatta cgacgtttcg gcatcaatcc 2169541 cgggtatgtc tttttctaat tggcggacaa attgaagcat aaaattgtgt ctttcttctg 2169601 ccagttcccg tgcagtgtct gtattcatca tatctttcag ccgcagcagc ttatgaaaaa 2169661 aatgagcgta ggcgctttgc tcatctccat aaaggccatg cccttttgcg cccgcaaaca 2169721 tgaaagctct cgcaatgccg acagcaccaa tcgcatcaag tctgtcagca tcctgtacag 2169781 cttttccttc aattgagagc ggctccttcg ccaatttccc cctgtcccga aaggacatcc 2169841 ttgttataat atgaatcacc ctgtcagcat tctcttttcc tactccgaaa aaaacgagct 2169901 gatcatatac ttcgctcaca gaaagcctga ccgtgtcagg cagcttcaca tcaattaaat 2169961 catgaaccaa agccgccgtt tcaacaatga acaaatccgc tttttccttt tctccaatat 2170021 acgctgcaag atctgctact cttgatacat gatgccagtc atgtccagag ctttcgtcag 2170081 tcaggataga ttgaacccat gtcctgattt gctctgcctg cttcaattcc ttcacaaaaa 2170141 caccctcttt ttattgctct aatagcttca cgatatcgtc ttccaactct ttcggatttg 2170201 tatttggtga ataacggcca acgatttctc catttctatc cactataaat ttcgtgaaat 2170261 tccacttgat cgccttagtt cccagcatcc ctttcgcatg ttctgtcaaa tacacaaaca 2170321 gcgggtgggc gtttttcccg tttacatcca cttttgaaaa cataggaaat gtaacaccgt 2170381 aatttgtttc acaaaattcc tgtatgtcag cctcttcacc aggctcttgg ttcatgaatt 2170441 gattgcaggg gaaccctaag atctccagcc cctcctgctg atatgtatca tataattcct 2170501 gcagctgctt caattgggaa gtaaaaccgc acttacttgc tgtattcacg atcatcagta 2170561 cctttcccgc gaaaggctga agtgtcatgt ctttccctgt gattgtacgt accttcatat 2170621 gataaataga catgtaagtc cctcctatgt ccttggtgct gattatttta ccttttttaa 2170681 atcgcaattc aaaatgtaaa catcaattaa gaactcataa gaaacctaac gatatgagcg 2170741 tcagttcatt atcaattcat atggctcgtt ttttatctta tcattctata aaacattaca 2170801 attccctctt acatctttga aaatcatttt actgtgaaac caaaaggcgt gtcagtgcgt 2170861 tttatttaaa gagttttctg ttgtttcccc ctcaacacgt atagatagat tgaaaattgg 2170921 cgtgaaaatt cctataatga agaaaattaa acggggaaat aatggaggtg gcacgttgcc 2170981 tattaatata ccaacacacc tgccggcaaa acaggtgctt gaaagtgaac atatatttgt 2171041 aatggatgaa agcagagcat ttcatcagga tatccggccg caaaaaatta ttatattaaa 2171101 tttgatgccg aaaaaaatcc aaacagagac tcagcttctc agattgcttg gaaattcgcc 2171161 tttacaggtt catttcacat ttttaatccc aagcacacac acgccgaaaa atactgcgag 2171221 agaacacctt gacgaatttt acacgacttt ttccaatatc cgtcacaaga ggtttgacgg 2171281 catgattatc accggtgcgc cgatcgagca tttggcgttt gaagaggttt catattggga 2171341 agagctcaag gaaatcatgg agtggagcaa aacaaatgtc acttcaacct tgcatatttg 2171401 ctggggtgct caagcaggtt tgtattacca ttacggtgtg gaaaaaattc aaatgccgaa 2171461 aaaaatcttc ggtgtgttcg aacataccgt tctttcaaaa cacgaaagat tggtaagagg 2171521 ttttgacgag ctatactacg tgccgcattc ccggcataca gatataaata tggaacagct 2171581 tcaagcagtg cccgagttaa acattcttac cgcatcaaag gaagccgggg tttgcttaat 2171641 tgtgtctaaa gacgaaaaac aagtcttttt gacagggcac cctgaatatg atacaaatac 2171701 gcttcttcaa gagtatgaaa gagatttgga acgaaacctt tctactgtcg aggcccctaa 2171761 acattatttt gcaaaaggca gcaacgagcc agtgaatcgc tggaaagcgc atgccacatt 2171821 attgtttatg aattggctga attattacgt ttaccaagaa actccttatg aatgggacta 2171881 atttttcttt ttttagtgat acgctgagca aaaaatatga taaaatacat ctgattcagt 2171941 ctgcgtataa caaaaattta aaatactgga atccaaatca tttaaaatta gcttaacttt 2172001 ttcactgcat taataattcg attatgtatt tgtgttatgt ttatgtatag acaataactc 2172061 cttacgatgc atgaagcttg cttgttgttg attacattga ggtgaattta cttgaatacc 2172121 aataaaagag tattaatttt gactgcaaat tacggaaatg gacatgtgca ggtagccaaa 2172181 acactttatg aacaatgtgt acggctcggc tttcagcatg taacagtttc taatttgtac 2172241 caagagtcaa atccgattgt ttcagaggta actcaatacc tttatttaaa aagcttctca 2172301 atcgggaaac agttttatcg tttgttttat tacggagttg acaaaatcta taataaacgt 2172361 aaattcaata tttactttaa aatgggtaat aaaagattgg gcgaacttgt cgatgaacat 2172421 cagcccgata ttattattaa tacatttccg atgatcgtcg tgccggaata cagacgccga 2172481 actggaagag tcattcctac cttcaacgtt atgactgatt tttgtcttca taaaatttgg 2172541 gttcacgaaa acgtggataa atattatgtg gcgacagatt acgtgaagga aaaactgctg 2172601 gagatcggca ctcatccaag caatgtaaaa atcacaggaa ttccaatcag gccgcaattt 2172661 gaagaatcca tgcctgttgg cccgatatat aaaaagtaca atctttcacc aaacaaaaaa 2172721 gtgcttctga tcatggcagg tgctcacggt gtattaaaga acgtaaaaga gctgtgcgaa 2172781 aaccttgtca aggatgacca agtgcaagta gttgtcgtgt gcgggaaaaa tacggcttta 2172841 aaagaatctt tgagtgcgct tgaagcggaa aatggtgaca aattaaaagt tctgggctat 2172901 gtggagcgca ttgatgagct atttcggatc acagattgca tgattaccaa gcccggcggc 2172961 attactttga cagaagccac agccattgga gtgcctgtca ttctgtacaa acccgtgcct 2173021 ggccaggaaa aagaaaatgc aaacttcttt gaagaccgcg gagctgccat cgttgtgaac 2173081 cgtcatgaag agattctcga gtcagtcact tcccttcttg cagatgaaga taccttgcat 2173141 cgcatgaaga aaaacattaa ggaccttcat ttagcaaact cctctgaagt gattttagag 2173201 gatatcctga aggaatcaga aatgatgacc gccaaacaaa aagccaaagt gctatcgtaa 2173261 tggcgtactt gagagcatac gaaaatcgtg tgctcttttt atttatattc agccatcaat 2173321 aaaagcggtt acattttttt atggaacttg cccttctttt gaaaaataag ccgtttcgca 2173381 acttgacggg tgctcccaga tggtgtatag ttgaaccatc atttaacaat gaatcaaagt 2173441 tagatgatga caaaattttt tttagcacat gggtgctaca gtactaggag gaattaagca 2173501 atatgcaaaa cggtaaagta aaatggttca acaacgaaaa aggattcggc ttcattgaag 2173561 ttgaaggcgg agacgatgta tttgttcact tcacagctat cgaaggagat ggatacaaat 2173621 cattagaaga aggacaagaa gtttcttttg aaattgtcga aggtaatcgt ggacctcaag 2173681 cttctaatgt tgtaaaactc taaactcaat acatgatgat gagatgacaa atagaggaga 2173741 ggcattcgcc tctcctattt gattttcatc tggatttcaa tcgccaaaat gttttgttta 2173801 cacctctgtt caatctcttc aacatacttt tccattgatg gttttccttt tttcgcgata 2173861 tcggccagtt cttctaaatc actgtatatt tctataaatg ttttgtgaag gatcaacttc 2173921 aagtctttat catccatagc tgcgttcccc ttctctatca agatacctca aatagtaaaa 2173981 cggtcctatt tattctggtt caatagttat atcggcttat ttttattttc ttttctattt 2174041 tggtacataa atttcaaaaa aactctgcaa aataatggcg gaggtgtttt ttgtgacttc 2174101 agaatttcat aatgaggatc agaccggctt tacggataag cggcagctgg aactagcggt 2174161 ggaaacagcg cagaaaacaa caggagccgc gacgagaggc caaagcaaaa cattagtcga 2174221 ctctgcatac caagccattg aggatgctag agaactgtca caatctgaag agctggcagc 2174281 tctcgatgat cctgaatttg taaagcagca acagcagctg ctagatgaca gcgagcatca 2174341 gctggatgaa ttcaaagaat aaaaaccgca gcttctgcgg tttttatttt tagtgattgg 2174401 ttaagacatc tccgtattgt ttcaactttt caccaaccgt acatttattg atacaaaatg 2174461 aatgcgcata agttttgcca aattctttgc gaaactgctt cttaataaaa cagtccttgc 2174521 aatattcatc gtgcagttct gtcagttctt taaagatcat tttcttatcc aatatcgtca 2174581 tctccgttac ggtctaattt cgtgtggctt tctacgaatt gatgggatag aattttttta 2174641 gcgaggccgt cagcttcctg attgtctttt cgttgtattg tttcgtaggt tggagtaagc 2174701 ttcagcgatt caaggagtgc ttctattttg tccagccatt cattatgaga tggatcataa 2174761 caaggccagc tgccgtcaag ctgattcagc acaacaagcg agtccccttt gattgtaatt 2174821 gaatttctgc ttgccccaag ctctcttact tctcttattg cttcataaag cgctgcgtat 2174881 tcagcttcat tattggtttt cagccggaag cttttatttt ttctcaagcg atgccgggtt 2174941 cctcccaatg aataatagat gacgatcccg agaccggcca gttcgctctc tttatcgaaa 2175001 ctgccgtcaa aataaacagt aatgtcatca ggctcttgag caagctcctc tgtcagcttt 2175061 tccaattcct tcagcgtcca gctgccgcct ttctcgtctt cgaactctag ctccttcatg 2175121 tatggaaaac ggccaagttc tctggcgaac gtacgtgcct gctgtgctgt cagccagtct 2175181 tcgctaaaaa atgagacgga tcccgttcct tttgcttcta ttttcaaatg cggtctgagc 2175241 ttcattacaa tcaccttacc attcattagt tgccgggctt atgctataat caaaccaatc 2175301 ttaccccgga aaggaagctt tttcatcttg tttaataatt cgttttggat cttttttgcg 2175361 atcattcatt ttatcattgt tcttttattt tataaaggat ttggcaaaat gggactgttt 2175421 gtttggatcg gttttgcgac agtctgcgcc aacctccaag tcgtcaaaac agtcgaactg 2175481 tttggcttaa cagcgacact cgggaatgtg atgtatggca caatcttttt tgcgacagat 2175541 gtgctgaatg aaaaatacgg accagctgaa gccagaaaag cggtatggct cggattctca 2175601 acgctcctga cgctgacatt tgtcatgcag ggcgtgctgc ttttcgaacc ggcttccagc 2175661 gacatatcac aaacagcgct ggaaacgatc ttcggattcc ttccgcgagt tgcgttagga 2175721 agtctgcttg cctttatctt cagccaaacg ctggatgttt atgtatattc ggcaattaga 2175781 aggatatttc cttctgatcg gcttttatgg ctcagaaacg gcggcagtac agcagtcagc 2175841 cagttgtttg atacattcat attcactgca gtcgcctttc tcggcattta tccggcagac 2175901 gtgtggcttc atatttttat ttctacatat ttgattaagt ttgcggtatc tttaatttca 2175961 ttgccttatg cctatgcagc caaaaaaatg atacctaatg atgaaaggag ttcataatgc 2176021 ctacagaaat atatgtagac ggcgcaagcg ccggtaatcc agggccttcc ggtatcggca 2176081 tttttatcaa acatgaggga aaagcagaat ctttctctat tccaatcgga gtgcatacaa 2176141 accaggaagc ggaatttctt gcattaattg aagggatgaa gctatgtgca acgcgcgggt 2176201 atcaatcagt ttcctttcga accgattcag atattgtgga acgcgccact gagcttgaaa 2176261 tggttaaaaa tataacgttt caaccgtttg tagaagagat catccgatta aaagcggcat 2176321 tccctctttt tttcatcaaa tggataccgg gcaagcaaaa ccaaaaagcc gatcttctgg 2176381 caaaagaagc gattcggctg aatgaaaaga attaaatctt gatcattggt tcatcctaat 2176441 ggcgaggtga actaacatga aaaagaaaga taaaggccgg ctgaccggcg gtgttactcc 2176501 gcaaggcgac ctggaaggca atacacataa tgaccctaaa acagagcttg aggagagagc 2176561 aaaaaaaagc aatacaaaac gctagagagg atctaaacga tctctctagc gttcagcttt 2176621 tcaagcatac gctcaattcc tttaatttgg tggcggcgaa gcatgtcagc cgcctgctcc 2176681 atttgcaaag taaataaagc gtctttcagt gtgcaggcca gcggcactga gcaatggatt 2176741 tccgcaagct tcctcgacat ctccaaatcg cttaaacctt gctgaatttt tccctgctgt 2176801 ccttttggaa gaagagaaag attttccaat aaacggtcaa tcgtttcgta ttcacgaatc 2176861 agtttgtagg ctgttttttc tccaatgcct ttgactccgg gatagttatc actggaatca 2176921 cccataagcg ctttaatatc aatcaaagcc ttcggcatta cgcctgtttc ttcataaaaa 2176981 gtctcttttg tatagacttt ataatttccg attccttttt gaagcaaagc aacgcttact 2177041 ttatccgtta acagctgaag taaatctctg tcccctgtta ccaccgtaat gtccgcttca 2177101 ttcgcaaata aatcggcaag agtaccgata cagtcatccg cttcatagcc ggcaaagcca 2177161 atattcatga ttccaagctc tgcggctgct tcctttgcca aatcaaactg cggaatcagc 2177221 tccacaggcg gcgcgctgcg gttggcctta taatcttgga acaagtcatt tcggtacgtt 2177281 ttgctcccca tgtcccagca gcagacgacg tgtgtcggct ggaatgtttc cacagctgta 2177341 atcaaatgct ttaaaaagcc gttgacgccg ttcgtcggca ccccgctgtc atttatcata 2177401 aagttgcgat gtacggccgt ggcaaaaaag gcccggaata aaagagccat gccgtcaacc 2177461 agcaatagtt tattattatt catcaaataa ctcccttttc tttcattcct tctattttat 2177521 cataaagcag cccaaaaata aaaaacagta tctctttaat tagagatact gtttgaatat 2177581 ttatcaatcg ttgtgtcttt tgttgctggc gatcagcttt tcagcttcgc gtcctgcgta 2177641 agagtcaaaa tgggtttgaa atccgttttt ctttttggcg ttgttattcg cctgtgcatt 2177701 tctgtttccg agctttgttc tgcccaacat gaatcccccc ttacgtcgga tgcatatagt 2177761 atatgcttcc ggcaggaggt tcactcgcga caggatcatc cagcttacat gcggcttacg 2177821 tattctctga ccatttcttt tgatacaagc cgtcttgtcg ggacgatgcc ttttttagcg 2177881 agctgattca tttgctcggt aatttcatta attgcatctg tagtataagg ctcatcgttt 2177941 ctgcatttag caacagcttc ttcaatcgcc aattcacgca tattttcaag acgcataaat 2178001 gctttgatat gctcgtgctg ttttgatgaa tgtgctgaaa ttgctttatg tacctctgac 2178061 attaatcgtt catctcgctt ttttctattt agtctatcat gacttgaaat acaagccaac 2178121 tgaattttac atttttattg tattgtctga atttttccag gagatgcacg cctgatacgc 2178181 catttcaatc tctttcgcat gttccccttc cgcatatcct cttaaatatg tctctttttg 2178241 atccgttatt tgcgcgattg ctttttcacc catatcttcc tgtaagcgtc tgaggtgagc 2178301 agtgtaatga gatatcaggc tttcttcttc attttttatc catgcctctg tgattttcgt 2178361 aagtttcatc cgtacagctt cgataaaggt cgcttttcct ttctgctcaa aaaactgctt 2178421 cggtgatttg atctctttta gttcctgctc aaaagcacgt tcttctattt ccggttcaac 2178481 ttccttcaac tgtatgccgt tcgaatgctg atcacccgca taaacggaaa aataaccgtc 2178541 ctcgtttaat gttttttgaa aatgatccag ccattcttca ttgatatgcc gttcgatgaa 2178601 accgctcatg cgaacatcaa gcgttttgat ttcctgaata tattcaaata gatattcatg 2178661 taaggctgtt gtcatcgctt tactgacgtt ctttttccaa tccccgtttt gcagcccggg 2178721 atgaaatgcc gattttaata aatcatttgc aaaatatgat aatcgctgtg caatgtgata 2178781 tagctgctct cttgtatctt tttttacttt ttcaatgatg gtttttgagt tccgccgttt 2178841 ctcgatatcg gccgctgtcc gctcaaatga cagcataagg cactgtttct gcgcttcctt 2178901 ctcttctcgg gactgatgct gggattggtg aagctgaaaa acagtttcgc atagtttgtc 2178961 tgcctccgaa ctgagctgcg ctgctgacgc tttttttaca tccacttcga taaaccggtc 2179021 taagtgtttt cttactttcg agaactgatt ataaaatgac tccggttttc ccaccagttc 2179081 ctccttactt gatacggtaa agagctgcgg ctcataaacc ccttctttta caagctctgc 2179141 gctgacataa tcggtcactg tttcgagctc tgttttatct tttgcaaggt ctgcagcatt 2179201 aataataaaa aacattttat ccatgctgag cgattctttc acaagtccaa gctttcgcaa 2179261 aaatgaacgg tctccttttg aaaaagagtg ctgataataa gtcatataaa aaaatgcatc 2179321 agcatctttg atatattgga atgccagttc tgtatgccgt ttattcatgc tgctcgcgcc 2179381 gggtgtatca acgatcgtaa tccctttttc agtgagcggg catgtatagt agaccgttac 2179441 ctctttcaca gcacaggccg ttgtttcctc tgctacatac ggctttaatt cagagagcgg 2179501 aatcgttaat ttcttctgtt cctgtatata ctgctgatac ttctcgtatg caagcaggaa 2179561 attgctgatc aatttcacgt gttcttcctg cagcctgttt tttttgactg ccttttccca 2179621 cttctctgtg aaggaacggc ctgccggctc ctttggtatt ccggtgagct gcaaaatttc 2179681 agccgttaag tcatcctctg tcttaaacac tacattcgct gttttgttta agttgccatt 2179741 gattggcttt gtgatcttgt taattgtcgc tgtggttggc gttggtgagg atggcagcac 2179801 tctttcgccg acaagcgcat tggcaaatga tgatttcccc gagctaaagc ctccaaaaag 2179861 agcgagtgta aatttccgtt cctcaagcct tttcaccctt tcacgaaacg ctgaagtttg 2179921 ctttaacaac atgctgcatt cgcctaaaat gtcagacaaa gtgtaaaagc gtttgatttg 2179981 gtcttgaagc ggcatttctt gttccatttt gatttctgat ttcggcatcg gctgcgccgt 2180041 cagctggctt cggccttgtt tctgctctgg agccgccact cttgttttct tcgatttaaa 2180101 ccattctgtg tctatatgca ttgggcatgc ggactcttct tcccaaatgg cccacaggcg 2180161 atcggttttc tctcgggcat tattctctaa acgtgcctgt tcttgaagaa agacaagttt 2180221 ttctgattct tggacgagcc ggtcgttaat tgtttgcaca tctttggaaa cacgctcttt 2180281 caccatagcg gagagcacct ttatgatgtc tgcggcttct cttttcgcct ctttccggat 2180341 gagctctgcc aagtcttttg tatattgcaa tacatattca gaggaaaagg ctgcaccatg 2180401 cttgaccgcg tgttcaatga tgcttatatc aagcggtgtg cgataggcct gaatcagctt 2180461 ttcactttca gcggtataga catcaaatac cttggcgagt ttatgaagcg tgtctatcat 2180521 atgccaatcc gcttcggcct ctgttcgttt tgccacatca gagaaaaaag cattccgcct 2180581 tttatctctt tcctgtgcag ttttcgcttt agaaaagaaa aagccggttt taaaggaagg 2180641 ctcttgtgat tctaaaaatg cagccgccaa ttcacgcatt tcaaaaggcg tcaggttggc 2180701 gttttttaaa atacgattga tttcttcctg catcctcttc tctgcctcag tcatttgttt 2180761 ttcggcctca tccaattgat cacgcagcga ttggaccagt ccagtatgga tattaagctg 2180821 ttcagcgaaa ctcggagcgc ctgtttcgtc tttcttcagc atttccgtat gttcctttag 2180881 cagattacgg actttttgtt cggttaaagc ctgcatattg ctttttgatt gctgttctat 2180941 tctgcttaac tcttctctca gggcccccat ctgattgaac gggtgatccg gttctgttac 2181001 tgatgtaaaa tagagcgctt cccttgaaat cccttcattg caaagcatct cctctacctg 2181061 cgcttgatag tctccaaatt tcgtctccgt ctcatcatgg cggtcaattt gattgacgat 2181121 aaaatacaca ttcggaatgc tttcttttat tgatctgaga aactttacat tttcctcagc 2181181 gtgcacgtga ttatagtgaa cgacgtaaaa cagcgcatcc gcttggtgaa gaatagaagc 2181241 agccgataga aaatgcgcat catctgttga atctatccct ggagtatcaa tatacgcaac 2181301 cccggaatcg atctcagtat acctgtcaaa aatttcgacg ctttcaatct gttccccgtc 2181361 tttacaatat tgctgcacct tgtctttctg gtaagtccct tccagctcag cacacgctcc 2181421 gtctgttgta tgaagccgaa ctcgcttttc cccgtttctg atcacaacaa ggttagcgct 2181481 tgtcggaatc gggcttgtcg gcaaaatatt ctccattaac aggcagttca gcagtgacga 2181541 tttccccgct gaataatgcc cggtaaacgc gatataaacc tcttcatcag ccgctttttt 2181601 catgaccgca gccagtttag cagccctttg ttcatcttga ttctcaataa attgcttata 2181661 aagttccccg gttttatgca aaagctcttt tctgttttga tctgtcataa gtctgaaccc 2181721 ctttgtgccg tttcaattgt gaaccttttt cgaaagatct gaattcattc ccttttcatt 2181781 ttacacaaga ataaaccaaa tttctttagg agaatagaaa aaagccgcca ttacggcagc 2181841 ttctataaaa gaaaatctgc aacttttaca agttccagat tcatcaaaca gatttattag 2181901 agattccttt taatacaaaa ccaattaata cactatatgt acaaaccgct ccaagcaaaa 2181961 acagcattgt catttgcttc accatcctga ttgagaatct ttttcaaacc cattttaaca 2182021 tggttgagaa tgattttcaa tcgctatttt acgctgtatt cctgtaatgc tttgtcttct 2182081 gcgcgaattc tgacgcttaa caacacggca ttgaaaatgg aaaacagaca catggtgacg 2182141 tatgcttgat aaagcagcgg aatcagcaaa atttcgagga taacaacggc atagtttgga 2182201 tgtttcatcc atttatatgg accttttttt acaagctcta cacctggaac aacaaggatt 2182261 ttcgtattcc aatatgctcc taaggaacaa agcgcccaat accgtacgat ctgtacgctt 2182321 aaaatcactg cagcgatacc gagccaccag ctggacggct gtttattcat cagcagcacc 2182381 tcggcaatta aggacaggaa aaaaaggata tgcatcgtaa tgatatacgg atagtggctc 2182441 tcgccaaatt caattgctcc ttgcttcttt accttttgtt cgttttgcct ggccactgcc 2182501 atttctgctg ctctttgaac aatgagaatg gcgatcaaca accaaaacat gagtcaggcc 2182561 cccttttccc agctgaataa tagcaactct gatgagaaac ccggccctaa tgcgccaatc 2182621 agtcctcgtt cagcttcctt tttatgtccg ttctgcagat ggtctttgat cacatacaag 2182681 attgtggctg aagacatatt tccgtgcttt tgcaaaatgc tttgcgcaga tgaaagcttt 2182741 tctgacgaca gcccgagact tttgatgtat gcatcgatca ctttttttcc gcctggatgc 2182801 gccaaaaaaa cactgatatc atggaatgac agcttatgtt tgtccaaaaa aatctgtaca 2182861 tttgttttga gccatttttc caccaaggtc ggaatgtctc gtgagaaaat gactttgaat 2182921 ccttgatcgg taaagtccca gcccatgaca tcttctgatt gtttcatcaa aacagattgg 2182981 gcgtccatta tcttcggcgc aagcttcagc tttgacaccc tgcggtccgc cttctctccg 2183041 cataataaag ctgcggcaat gccgtcacca aaaagcgagg tgccgatcag attgcttttt 2183101 gttttatctt ccggctggaa tgtcaggctg cacagctcgg cagaaatgac aagcacaaaa 2183161 gcctcaggat acgctttgca gtattcggct gcacgcgcaa gtccgctggc tcctcctgca 2183221 cagccaagcc cccaaatcgg aatccgcttc gtatatggag aaaacggaag ttcattcata 2183281 agccgcgcct cgatactcgg tgtggaaaga cctgtactgg agacgaaaaa aacagcttcc 2183341 actttctcat aaggaatggc ttcttgaaaa aattccggat gagagaggca ctcacgaaca 2183401 gccgctctgc tgtgtttaag tgtttcttct atgtatattt gatttttttc ttcaaagctg 2183461 tgcccctctt tataccattc aatcggctta acaaactgtc tcgaatggat ttgcccgttt 2183521 ttaaaggagg ataacagcct gtcaatatcc ttaaaagaat gctgaaacat atagcgggcg 2183581 aactcggccg ctttctcttg gtttacatta tacgcaggaa gacttgttcc aatggataaa 2183641 ataaacgcca tgcgatcacc tctttgcata cattgtgccg caacaatctt ttttatatgc 2183701 aaaaaaaact ccgccgcggc ggagttagac tgctgttttt tgttcagcga ggtcagcttc 2183761 ttgttctatt tttttagctt tagaaaaaac gttatataca atatttaaga cgactgcagt 2183821 aaagctgccc gccacaatgc cattcgttgt aagcagcgtt aaggcactcg gaagctgttt 2183881 gaaaatatcc ggcacaacgg tcacaccgag ccccaatccc actgagcaag caacaatcag 2183941 cagattttcc tgtttcgcaa aatcaatgcg gctgagcatt ttaattccgt aagcaatcac 2184001 cattccaaac atcgccacca ttgcaccgcc caaaacagcg gatggaataa tagtcgtgaa 2184061 agcagcgatc tttggaaaca gcccaaatgc cattaggatc acacctgtga ccacaatgac 2184121 ggcatttttt ttgatccctg tgagctgaac aagcccgaca ttttgagaga atgccgtgta 2184181 aggaaaagcg ttaaaaatac cgcccagaag cacagccagt ccttcagctc gatagccttt 2184241 agacaaatct atctctgtca aacggcggtt tgtcaggtca cctaaagcaa agtaaacacc 2184301 agttgactcc acaaggctga caattgcaac gatggacatc gtaatgatag gcgctgcgtg 2184361 aaaagacggc gctccgaagt aaaatggctg aatcatttga acaactgccg cgtccgaaac 2184421 attatcaaat tgaacttttc ccataaaata tgcgatgaag gtgccaatca aaataccgat 2184481 caaaatcgag acggacttga taaagccttt tgtaaaacgg tatagaagca caatgatact 2184541 caacacggta aaagcaagtg caagattgga gagatctccg aaatctgcac ttccttctcc 2184601 gccggccatg ttattcatgg caaccggcat cagtgtaata ccgataatcg taacaacaga 2184661 gcctgtcacg accggcggaa aaaacgatac gagctttcca aagaaaaatg aaataagaat 2184721 gacaagaatg cctgaagcga taatgctgcc gtaaactgtt gaaaccccat attcagatcc 2184781 aatcgctatc atcggcgata cagctgtaaa ggtacagcca agcactaccg gaagcccgat 2184841 cccaaaaaat cggttgctcc acacttgcag aagtgtagcc acaccgcaca taaaaatatc 2184901 aatcgatact aagtaagtca gctgctcgac agtcagtccc attgcttttc cgacaatcag 2184961 aggaacgaca atggcgccgg catacatggc aagaacatgc tgaatcccta aagacagcgt 2185021 tttgccgaat ccatttctca tgaatgaacc tcctgtacga aggacacttt tccttcttct 2185081 aaagactgaa ttcttgccaa agattccact cggtagccca gttttacaag ttcatctctt 2185141 cccggctgaa atgacttttc aataacaatg ccgattcccg caatagaagc tcccgcttgc 2185201 ttcacaatcg acacaagccc gtgcgctgcc tgtccatttg ccaaaaaatc atcgataatc 2185261 agcacatgat cctgatccga caggtgggtc ccagacactg cgatttggct ttctgtttgc 2185321 ttcgtaaagg aataaacaga cgctgtcagc aagttgtcgg tgagtgttaa cgatttatgc 2185381 tttctcgcga agacaactgg cacacccagc ttcaagcccg tcattacagc gggagcgata 2185441 cctgatgatt cgattgtcac aattttggta ataccgtctt ttgcaaacct agacgcaaat 2185501 tcatcaccaa ttctctgcat aagcagcgga tcaatttggt gattcaaaaa agaatccact 2185561 ttcaatacct gatcagataa tacgacgcct tcttcctcta ttttccgttt cagtgcttcc 2185621 atcctgtcta cctccgttat gagaataaaa aaagcattgc ccgctcaaat aaagagcaag 2185681 caatgctgat atcacaaaaa accgtacacg tgcggttcca ttgctcaccc atagtcggac 2185741 atttacggtg cccggtagaa acttgcgtgc catatccacg cgattatatg agtgttccta 2185801 ttatattgta ataaattata tcaagattct aatctcttgc ataggctgaa aataaaaatt 2185861 cccgaacttt aattttgttt ttttagatat cattcgtatt tcaaggggat tcgatataaa 2185921 agagtctgac gaccgcgccg ccaggctttt gattataaca gatagagatt tgaatatttg 2185981 tttgataaat aatcaattaa atagcgaaca ttcagctctt ctcctgttgc atctttaata 2186041 atgtctaacg gctttttccg ttttccgtga atgtgcacct tttccgtcag ccattgcttt 2186101 atcggatgga actctcctct ttccaagaga gcgtcaaatt cagggagatc ctcaagcatt 2186161 ttttgtttca gctgagccgc atacatgtag ccgagcgcat aggatgggaa gtagccgaaa 2186221 tctccacctg cccaatggac gtcctgtaaa atcccctctg cgtcggtctg cggtgtaatc 2186281 cctaaataat cctggtattt ttgattccaa agcgacggca gatcttccac agacacttca 2186341 ttgctgaaaa tcgctttttc aatttcataa cggatgatga tatgaagagg atacgtcaat 2186401 tcatccgctt cgaccctgat aaatgaaggt tttgattcat tgattgcccg gacaaaatca 2186461 tccagggaga tgtccttgaa ctgtacaggt gatgcctctt gaatcttctt atagtacgga 2186521 gtccaaaaat gcttgttgcg gccgataaaa ttctcgtaaa ataatgattg cgattcatga 2186581 attcccatcg atgcgccgtc tgacaagttc gtgccactga gtgcttcatc aatattttgc 2186641 tcgtaaatcg cgtgcccgca ctcatgaatg gtcccaaaga tcgccgtccg gaaatctttt 2186701 tcatcatatc tcgtcgtgac ccgaacgtct ccccgattca gcgtagttgc aaacggatga 2186761 acggtttcat caagtcttcc gccatcaaaa tcgtagccaa gctcctgtaa aaaatacaga 2186821 ctgagctctt tttgcttttc tttcgggaac gcttttgtaa taaagcttgt atctggttta 2186881 tttccggaag ctgtcacctg tttaacaaga gggataatcg cttccttcag ctcagcaaac 2186941 aactgatcaa gcacctttac cgtgacgccg ggctcaaaca aatcaagcaa tgcatcataa 2187001 ggatgctctt gatatcccca atacgtaata aaacgtttat tgaattcaat cagctgttct 2187061 aaataaggag aaaacaagct gaaatcagat tttcctttcg cttcctccca cgctgtttct 2187121 gcctttgaac acagaatcac gtattctttg tattcagcct cagggatttt cttattctct 2187181 tcatactctt ttttcgccag ttccactgct tttttcgtat cttccgacaa gtcatcaaat 2187241 cgttcataca ggacatcgat aagctccttc attcgatctg atgtttggat attgaatata 2187301 tctgttgaaa gctggccgat actttcggca cgatcctctg agccattttt cggcgcgcct 2187361 gttctggagt cccagtgcat taacgcaact gcttcgctgt aatgtgagat tctttttaaa 2187421 agatcaaaaa attctttttc atatgtatgt atctccatat ccattccctc cctattctag 2187481 ccgttccatt acaggctaat ggaagggggt atgaaagtca aattgtttgt ataaaaggct 2187541 gccggtatgt tttgtggcag cctttttatt cagttgatcg tcatttgatt ttttggcgga 2187601 ggtgttctcc gctttttctg cttgattttt ttatctaccc acactgttgc cagcggggtt 2187661 aagagcgagg tgacaataac gcttgtcgcg ataattgcag ttgccgactc agcaactggc 2187721 gcaaatgagg cattcgcttc cgctaatgca tatggcacgg ctacagccgc ccctgccgta 2187781 gaagaagcgg ccactcccgc gacaccatct ccccgcgcaa taaaacgatc aagcaaaaac 2187841 aaagaactgc ccgataaaat gacgacagaa actccgataa aaatgccgag cagccctgat 2187901 tggatcagca ttccaaaatt caaggtattg ccgagcgaaa aggcgaaaaa tggaatgatc 2187961 gccggcacaa ccttgctgaa taagtctctg agatcatgat ccagatttcc aagtatacat 2188021 ccaagtaaaa acgggatgac tgtcgctgcc agcgtttccc atgggaatgc ggcaagtccc 2188081 gtcacaccaa acgtcaccat ggtcataaaa ggaccagatt ctgtactgat aaaggcgaaa 2188141 gcgcccgcat cctcttttct tcccatgtga ttcatgagcg ccaaatacag tccgccgttc 2188201 gtttcattca ttaccgcgac aattgctaaa acagaaaggc ctgcaaaaaa gccggattgt 2188261 atgccatcgt caggtataaa ttgcgctgcg atcacgccga gcagcgccgc aaatccgatc 2188321 ttccccaata ataacgtgat tccttttctt gcgatatagc ctgaagaacg aaaatcaatc 2188381 gttgctccta cgcaaaagat aaaaacaccc agtatcggca gcgttccggt aatcaaagca 2188441 cccgtaaacc ctccaaagaa ctccgctgtt ccaggcgcaa acgtgttgag cgccgctcca 2188501 agaaatagcg gaataatcat cattccgcca ggtacccgtt caattgtcgc cttgattttc 2188561 atattgtgga ttctcccatc ctccggttat gaaaaaacaa ttccacttac acttggaaaa 2188621 cagcctgcaa atcctctttt gaacagctgc ccaactggct gccgactccg acggcgccag 2188681 ctccggctct aagccaatca ggcacttcag acggatgtat cccgcctgtc ggaataaagg 2188741 tcacctgcgg gaaaggaccc gctaaatttt tcataaacgg aatgccaaac acaccgcttg 2188801 ggaacagctt taatgtcgta aaaccgaatg tcagcgcttc cataatttcg ctcggagtca 2188861 agacgccggg gatataatgt gtctttacaa aagatagatg ttcagcaaga tcagctgaaa 2188921 aacccggact gacaataaac tgcgcgccag ccttagcagc ttccccagct tgctgcgcgc 2188981 tgatgaccgt acccgcgcca attaaaatat cttccctatt acggaaggat tcgataatat 2189041 ctgatgcccc gggggtcgta tacgtcactt caactgcacg aatcccttta tctaataaac 2189101 tctcaatctg ctgacaggcc tcctgcttat cctttgaacg aatgactgca atcagctttg 2189161 cttctttcag acggttttca acgactttgg actccatatt aataatcccc tttcttttgg 2189221 tgaaccgttc tttgagcaga taaaaaagaa gctaatttct ccctggtcgg caaaccgtcc 2189281 atatcccccg gtgcctgcac ttgcaaagcg ccaatcgcat ttcccctttg caccgcatcc 2189341 ttgtacgaca aaccgtctag gataccgctg attacaccga ctgcaaatcc gtctccggcg 2189401 ccgaccgtat caaccacccg gtcgacccgg cagccttcta gaaatccttc acttgtcccc 2189461 gttttaaagt aagcgccttc ttttccaagt ttaatagcaa caaagctggc accttttttc 2189521 aaataatagt cggcaatgcc ttcaggtgtt ttttctccgg tcaatagctc tccctctgcg 2189581 atacccggga aaaaccagtc tgcaagccca gccagatcat tgattgtgtg taccattgtt 2189641 gcttgatcag gccaaagcga aggtcttaca ttagggtcga atgaaatggt cttccctgcg 2189701 tttctcatgt cgttcatgac atgatacgtg aagtctttca tctcggctga taaagcaggc 2189761 ggaatacctg tcacatgcaa atggcctgcg cattgaaaat aatctctcgg atattcagct 2189821 gtagttaatg tgcttgcagc tgagtttttc ctatagtagg taacttgcgg gtcgccttct 2189881 ttcacttttg acttcagcag cagcccggtg ggattttcgt cctgcgagcg gatcacgcgg 2189941 gacacatcca ctccctcttt tttaagctct tgtaaaataa acgttccgag ctgatcattg 2190001 ccgaccttgc tcatccatcc cattcgaaat ccgagtctgg caaggccgca ggcgacattg 2190061 ctttctgctc cggcaagccc tttagaaaaa gtggatactt catgaaggcc tccatactca 2190121 tttgcataaa acatggccat tgattccccg aatgtcaccg catcaagctt catctcttcc 2190181 caacctcctc ttagttgagg gcacctagga ttaaagtgac tttctcatga tgacttttgc 2190241 ctctaattca atggtttgag gcgctccttt gtcaccttca atccttttta atacacgttc 2190301 catcgccgtc ctgcccatat catgtgacgg ctgggcgatc gttgtaatgc ctggaccgat 2190361 cagtttgtac cactccgtat catcgaatcc tgcaatccct atatcttgag ggatgcgcag 2190421 gccaagctct tccatacagc tgatgatttt cagcataatc aagccattca aagccagaat 2190481 cgcttttttt tgctccggca tttccttgtg aaaagaacga agctccgcct taagctgctc 2190541 cttgtccttt acgtcaattt catgcaatct gacaagcccg ttcacatttt gaaccgaagc 2190601 catttcctga tacacagctg ctctttctgc acgagggctg atagaggaaa tcggttcggt 2190661 aaacagcgcg acatcagtat accctttgct gtacaccttc tgaagaatct cttttgtgat 2190721 ccatctgttg tcagtcgtta cggtatccag tttcagatcc ggcagtttcc ggtcaattaa 2190781 gattgttgga atttgctgtt cagcaaaagc gcggagtaca tccttgtttt cccctgttgc 2190841 gtttaaaatc aagccctcaa ccgaatgggc ttctagcttt aagagcattt cccgctcttt 2190901 ttcaggactg ttatctgtgt tgcacaccat aatgctgtat ccatattgat cacaaacctc 2190961 ttcgactccc ctgaaagcag cgaccgaaaa aggatttgta atgtcagcca caacaaatcc 2191021 gattaacttg ctttttttta ttttcaaacc ttgtgccatt ttactcggcc gataattcaa 2191081 ttctgcgatt gcctttttaa tgtttttcac tttttcagga gaaatcgcgt caatttttcc 2191141 gttaatatag cgggaaactg tcgatttcga aactcctgca cattcagcta cgtctttgat 2191201 ggttgtatgg cctgttgttt tctttttcat tcaagtgctc ctgtatctca tatatttgaa 2191261 accgatttca aaaccgttac aacaaaagaa taccataatt ttaaaatttg ggaagagttt 2191321 ttttaataat atgtcaattc attatttttt cgttgactct tttcactatt tatcctaaaa 2191381 ttttctttga aaccgttacc aaaatatttt cattcaagtg atgctgaaat cctaaccaag 2191441 ggggaaatat aatggaaaat cgttattctg tacatcctga acaagtaaaa cgctttacaa 2191501 cagaggagct tcgcagtcat ttcttaatgg attctttatt tacagaaaac aaacttacga 2191561 tgtattactc acatgaagac cgggttgtca tcggcggagc ggctccaggg caaagtgaac 2191621 tgaagcttga tgcaggtgat tttctaaaaa cagacttctt tttggaacgg cgtgaaatcg 2191681 ggattattaa tgtcggccag cctggtgccg ttagagtcgg cgatgatgaa tatgtgcttc 2191741 aaacaaagga ttttctctat attggaatgg gcaatcagga tgtatcgttt tcaagcctga 2191801 acggggaaaa agcgaagttt tacttcgtct ccgcttgcgc ccacaaaagc tatccgacac 2191861 aaaaagccgc cctatctgaa ctgacaccgg accgccttgg tgatgatgca gcgtctaatg 2191921 tcagaagtct gtacaaagtc attcatcagg atggcattaa aagctgtcag ctgatgatgg 2191981 gaataacgat gttagatcaa aacaacaact ggaataccat gccagcacac gttcatgacc 2192041 gtcggatgga ggcttatctt tatctggatc ttgaaaagga ctcaaaggta tttcatttca 2192101 tgggccagcc ggacgaaaca cgccatcttg ttgttggaaa tgagcaggct gtcctttctc 2192161 ccgcttggtc tattcattct ggcgcaggaa catcaaacta tagctttgtg tgggcgatgg 2192221 ctggagaaaa ttacacattt acggacatgg atctcattcc aatggatggg ctgaaataag 2192281 atgggttatc tacatgacgc cttttcatta aaaggaaaaa cagcgctggt gacaggcccg 2192341 ggaacaggga tcggtcaagg aatagccaaa gccctagccg gggctggcgc tgatattatc 2192401 ggcacatcac atacaagcag tctgtctgaa acacagcagc ttgtggaaca ggaaggccgg 2192461 atatttacat cttttacatt ggacatgagc aagccggaag cgataaagga ttctgcagct 2192521 gagctgtttg aaaacaggca gatcgacatc cttgtcaata atgccggcat tattcatcgg 2192581 gaaaaagcgg aagattttcc agaagagaac tggcagcacg tactgaatgt caatctaaac 2192641 agcctgttta ttctgacaca gcttgctggc aggcacatgc tgaaaagagg tcatggaaag 2192701 attattaata ttgcctctct cctgtctttt caaggcggca tcctcgttcc ggcttacacc 2192761 gcgagcaaac acgctgttgc cggtttgaca aaatcatttg caaatgagtg ggcagcgtca 2192821 ggtattcagg tcaacgcaat cgccccaggc tatatttcta ctgcgaatac aaagcctatt 2192881 cgggatgacg aaaagcgaaa tgaggacatt ttaaagagaa ttcctgccgg ccgctggggc 2192941 caagcggatg atatcggggg gactgcagtc tttttggcat cacgtgcttc agattatgta 2193001 aatggacata ttttagcagt tgatggcggc tggctatccc gctgacaaat aaaaaagctg 2193061 acgaacgatc gtcagctttt ttccattaca tcatgtgcgg ttcaacaggc aagacctttt 2193121 tgacctcatc aatgatgcgt tcattttctc cgccagcgta aatgtgaatc gagccgctgt 2193181 cttgattcga gcgaatcagg cgcccgatgc cctgccgtac acgtaacaac atatatggca 2193241 gatcaacttc ttcgaacgga tcttttttcg ctccgttgcg cttcgctgta aatacaggat 2193301 cgtgtggcgg gaacggtaat gaccaaatgg taacattctt caatgcgtca ccgggaatgt 2193361 cgagtccttc ccataagtga actgaacaaa gtactgtttc ttcttcctct tggaatttct 2193421 ctactaagct gctgatttcc tcatcacctt cgaagaaaat tggatacggc agctcccatg 2193481 ccgccgacag ctctttaaac tcgtttaatt cttcaaaaga agggaaaagc accagcgttc 2193541 ttcctttgta tcgtttgatt gtttcaatcg tttcagccgt tttttgttca gcgtccatat 2193601 ctgtttttgc gtatagatta atactcattt gctcgtcata atcataaggg gaatcaacag 2193661 ttaatgacaa ataatcatga atcccaagac tgtcggcaat ataatcaaac gaaccgcctt 2193721 ctgacagcgt agcagaagaa aagatataag gaattttctt agaaaacact ttttcgccaa 2193781 gtacttctgc taccgttctc ggcatcacga caaaggttga ttctgcttcc tttttctcca 2193841 gccagctgat cgcatccttt tgatatagag ataatgaata cgccatttgt tcaacatatt 2193901 cttccactac tgacagttcg tattgatcaa tcgtatacat ttcagactca aatacaagtg 2193961 cctcaccgat tttatcaagt aaacggcaaa gctcgtccgc cgcctttttg acacgatggt 2194021 cattttttat ttctaaacgg tgtgaaccgg ctacttcctt tgattcttca gaaagaacat 2194081 agaaaaattc gtcgtttgcg agaagcgcat cttcaatcaa ttctgcaaac tcttctctga 2194141 tgtcattttg cagcaatcgt tctaaaaaca attcaagagt agactgcttc actctatagg 2194201 ttagcgcttt ttgcgcagca aactctaaca agtgcccctc atcaaataca actgcactat 2194261 gatcaggcaa gagcggcagc tggccctctc gtttgcgtga ttcttccgtc cacacatgct 2194321 ccatataaaa atcatgggaa caaatgatta agtccgttga cttgcggtag taatctctgg 2194381 aaagtgtcag accgcatctg tgtctcatat cacaagtcag acagtcctga aacgagtcgt 2194441 agcttacgtc agaccactct tcattcgata gatttgcgta ctgcttacgg tcgccatacg 2194501 gataaaagcg ctgcatcgcc tgggactcgt ggacaaatga cggtaacgac tcataaagat 2194561 ccagccattt atcatcatca gaacgctgca ttgttttttc aagcttcttc aagcataaat 2194621 attgctcatg tgattttgac agccttgtat caattttcag atcaagatgc tcagccagct 2194681 tagaaatatc gccctctttt ttcaccagct gttcaattaa tgtttcatcc gcacaagcga 2194741 tgatggcagg tttgccgaca taccttgcat agctgattgc aaaaagaaga tataccagcg 2194801 ttttccccgt tcccactcca gcttcggcga acatgacttt tttctcttta aacgcccgct 2194861 ccagctgaaa agccataaat acttgctcgt cccgaagatc aaaccctttt tcgggaagga 2194921 tatcgtaaaa cacgtcacca atccaattgt tcaattcttc ataaaaattc tttgttttcg 2194981 ttaaagaaaa aggcaaacgt gatgttgtca cctagttcca acccccaact attcgacatt 2195041 cagaccacca ataatatcat tttccgctga tgaatacaat aaaaaacttg gcaatgccaa 2195101 gttttttgca gtttacttac gattgatcac atgcgacgat aaaaaaggat ggtctgttga 2195161 ataaatatgt tctaccgctt tttctaaatc agtttgcgca tgcgaaatca cagacggaga 2195221 cgaatcagtc ccgagctcct tcagctcgtt tgctgttgcg tcaagcgccc tttgaataag 2195281 attaaaatgt tcgctgttca gcatgagatc acctctgatg gaaataatca tcattgtatg 2195341 cgaacttttc attttatata catgctttac cgcatgttat caccgaaaca tgcacaaact 2195401 acacttgata ttccgtctcc ggattatccg tcttatcaac aatattctat cagggagtga 2195461 tgttgacatg agttatagaa accgattaga tcagcattct gaactgtttc atcacaattg 2195521 gacgcggcct aaacgttcaa agtctcaagt aaacggtcac actgaaatgt cccaaaccaa 2195581 cattatattg agaagcaacg cgaaagctca ccgttggtaa cgatagaata gggctgaaag 2195641 atgaaagaag acgcatgcag agcgtcttct ttttatgcgt tttctgtttt cttgcgctgc 2195701 ggtcttactt ttgaccagta ttgataataa tccgttttaa taaacccgtt aaagagtttt 2195761 cgtttcttcg ttgcttttct gccatatgct tcctcaaagt tttcatttga tgtcagcata 2195821 tacacagacc aagtatcaag cggctcgaac gcctgcccca tttctttgta catctgctca 2195881 acggcttttt tctcgccgag acgctctcca tatggcgggt tgccgacaat tacgccaaat 2195941 tccagatttg tggtaaagtc tttgacctgc atctgtttga actggattag atctcccaat 2196001 cctgcttcct ctgcattttc ttttgcgatt tgaaccatgc ggtggtctat gtcgctagcg 2196061 aaaattgtaa gcggctgatc ataatttgcc ttttcttcga cttcaagccg cgctttgttc 2196121 cacagatctt taccgatcca ttcccaatcc tctgatacaa aatcgcggtt gaatcccggg 2196181 gcgatgtttt ggccgattag cgccgcttct atcgcgattg ttccggagcc gcagaaagga 2196241 tcaacaaacg ggcggtcagg cgtccaattg gttaattgca ccaaagcggc agcaagtgtt 2196301 tctttaatcg gcgcaccgcc ctgatcgaca cggtatcctc gtttgtgaag gcccgtccct 2196361 gatgagtcca gtgtaatcaa agcctgatct ttcaataaag atatttccac tttatactca 2196421 gcacctgttt cttcaatcca atcattggct ttgccggact gcagcttgag cttttcgaca 2196481 attgcttttt tgacgatccg ctgacagtca ggaacgcttg caagtgttga ttttaccgat 2196541 tttccgatga cagggaattt cccgttttca ggtataaatg agcgccagtt aatcgctttc 2196601 gttttttcaa acagttcatc aaatgttttc gctttaaaag aagcaacctg aacctttatg 2196661 cggtcggctg ttctaagcca aaggttcgca cggcagatgg caagtgcatc accttcaaaa 2196721 ataactttcc cgttatcaac cttgcattcg tatcctaaat ctcgtacttc ctttgcgaca 2196781 acagcttcaa tgcccatcgg cgccgttgca attagtgtat acttcttcat cgtatcaccc 2196841 tgtcttttaa aacttttctc ttttcaagat aaaagctctc cttatacggg agagcttgtt 2196901 ttcatcattt taaatgtaag tggtctaacg ttctgtaagc catgttttgt tccatcgtac 2196961 tgcaaacggc tcatcacctc gtactcaggc ggcaatcatc tatctacaga aagcattctg 2197021 tccttctctc cgttgaattc cgttaagaag gttcccctac caaaatttgg gtttctcgct 2197081 cgaggggttt accgcgttcc actctcacca tttctagtga gacttcgtca ctgtggcact 2197141 ttcaaggata ctcagccata tccgaagacg taggcttttt tcctgccgtc agcctctaaa 2197201 gactgcccta gcttatgact tcgctaggca cgaacactac gggcatctca gcaccgtgcg 2197261 agcatggact ttcctctaca gattcaagat ctgcagcgat tacccgaacg ttaagaacat 2197321 gaattattat ataacaactg attacaattt acaagcgcca tttttttcaa gcgtgatcaa 2197381 tcataaagct tgctgccaaa aacgtgtttt tctaagttag acagccgttt taaaatatca 2197441 aagtttgttg tgttagattg cacaggctgt tttttgctgg cttcttcaag ctgttttttc 2197501 agctgcagat tttcctgctg cagttcttca atttcttgat ggaaggtttc ataatcctta 2197561 ataatcatat ctaaaaattt gtcaacgtct tcttgcttgt agcctctaac gcctgtttta 2197621 aattcttttt ccaaaatttc tttcgcagaa agctttactt tatcagcaag catctttttc 2197681 acctcgtatc gtgaatcatc acatatattt tttcagaaat ctgtacggtt gtcaaatttc 2197741 tctctcattg ttagtagctg tcttcctcca ctgtcactct caagtcatcc attgtaataa 2197801 agtagatggg atagccatcc tgttcgcgcc ttttttccgc tgtcccaagc atatacttag 2197861 gggagccttc cttttccggg tcatataaaa gcagaagccc gtcggactta tcaatgaaga 2197921 actgattttt ttgtttgaat tgaagcgggc tttcataagg acggtgagtc aggcttgctt 2197981 catagtctgc ctgagccaga actgcttcat actgttcttt attcggttct ttccagttct 2198041 tttcctgctc gtaaaatggt gtgatgacag ctacctttaa gtcagggtat tcctcctgca 2198101 aatcatatgc agcttctgcc gcccacagct caactccaag ctggcccgaa attaaaatcc 2198161 attctaatcc ttcatccaaa aaagcaatca gccggttttt aatggctttt tttatgtaat 2198221 acagcgcctt gtcatcctgc ttaaatatcc ccagttcaaa cggtttatag cccgttattg 2198281 ccaatacttt catcatttca cctgctttaa aaaatggggc tcccgtgggc cccatttgtt 2198341 gtgctgcatt gtttacacca tcaagctgca cgttttccat actagtagtc gcagcaaggt 2198401 tttcctgctt gaaaatgctg atgcgtagcc gggtcaacat ttgagaaagt gtgtggaaag 2198461 tagtgaacgt gctgaaaatg ctggtggttt acgtttgttg tatgctgtgg gtgaatgtgc 2198521 ggcacgatag tcttcgaaaa cgtatggtgt tcacagcaat gagtaggatg gacaattggc 2198581 gccatcatat gcggtctgca gtgatgcatg ataaaatccc ctttccataa actttattac 2198641 aatactaagt tatgaaaaat aaggggtaca tgttctgatg caaagaccta ttttaaaagt 2198701 gtgcaattaa gctgtcttta aagtttgaaa acacaaaagc aatcaaaaat accacaacaa 2198761 agaacaagta aaaaacaccc ttatacatac caactctccc tttaaaaata actaacgtca 2198821 ttttacagga ttcgccgcta ttctacaaca aaatcaatgt gaattcagca aaaaaaattc 2198881 atggcgaaac aagtcgtctt ttgcgctttc ccggggaata tttaagagga atatttcctc 2198941 tttagccggg caattctcac atgcagtttt tcagtttctt tctctgataa gcatgccgca 2199001 tcgctaagcg attgctctgc tacttgcaat gcttttccga attctttttt cttatgctca 2199061 aaatatttcg cgagctctat tacagcagcg tatctgcact tctggttttg cgagcgggac 2199121 agcttttccc aaagcggcac tgcttcttcc aagcggtttt gttttttgta caggagcgat 2199181 aaatccagcc gtgcactgtc ctggtcctca aacgattttt ctataagcct ttccaactgc 2199241 ttgatcgctt ggtccgtttc tttatgagcc ataaaccatt tcgccatagc ataggcttca 2199301 ctgtgttctt ttggcgcatg tgattctgaa aggatttttt tagacatatg gatgtacaat 2199361 gaaatgagtg ataacacatc catttcatta tgatgcagga caccttttaa aagatccggc 2199421 tcttgcgcct tgataaaatg aaagtaaagc attggcgcca agtagcccgg tgtgtcttct 2199481 agcctgcgga tgccgagctc ctctttttca accgtgccaa gagatacacg gtccattttg 2199541 tgtttccaca ggcgtctagc tccatgcaaa agatcaaagt ggccaaactc cggaagcttc 2199601 ggaagtctgt cacggatcaa ggtgtgcctt gttttcacct gcggccaatc aaaggctttg 2199661 ccgttgtagg tcacaagtga tgtaatgtca acctcgctta aaaagctttg gtacaaggcg 2199721 acttcgttcc ccggtttggg caaaagatgc tgtttgactg tcactcggtc ttcatatact 2199781 ctcgcatgcc caagcaaaaa aatggtattc ccagctccac ccccaagacc ggttgtttct 2199841 gtatcaaaga aaaagaggtt gtttttgtta tacccttttg ctgacaatgt atgcgacagg 2199901 ccgctttgat tccacagtgt gatcacttcc tcaagctcag aaaagctgta taacccatgg 2199961 cggtgagaaa gcggatattc tacttctctg atgaggcaat attcatcttc gaagatgaaa 2200021 ggcttcatgc caaaagcctc ccactcttct aaaaacggga tgtcatcaaa gtggttttct 2200081 tgtttgcctg cttctatttt ttgttctcct tcgtcgagcg ccatgtgctt tttcatccgt 2200141 tggagtttcc cttttaatga catatccggc ctccctcctt acgacatttg atccaacagc 2200201 tgcaaaattc tttcctttgc ttttatccct tctatttccg tacctataca agacggacag 2200261 ccgtcatgac aaggacaatg tgtaatcagt tgtttcgccg cttcattaat gtctgaaaaa 2200321 cgtttaaaga cttcctccgc caaaccgata ccgcccggat aatgatcata taaaaatatg 2200381 gttggcaatc cggtatgggc tgctttaatt tgagaaacaa catgaacatc atttcgatca 2200441 cacatgatat acacagggac aatatgctgc agcacattcg agatgccaag aagcagctgt 2200501 tccagtgtct tttccccgat gtcttcatcc gctgttttga tttcgagcca agctgcactt 2200561 gtatgcagtt cttcttccgg caaatgaata ggtccagacc caatattttc aaaagtggtc 2200621 atttttattt ttttaaaaat ggtcggcagg gcattgacag tgacgtctcc gtagtgcaat 2200681 gacgtacggc ttttttcttt cgttttatcg atttctaata ccttcagctg aactgccagg 2200741 tttgcatccg tataatattc gacatcgact tttctgacat acgccttttt atggtcccaa 2200801 tcgagcttct caacttgata ctgaacgcct tcatgcaaat aaatcgcttc atcatgcaaa 2200861 agcgtcatcg cactaaaacg gtccatttca ccgataatcc ttacatttgc aatatccgac 2200921 tgatcaacta taacgacatt ttcctgggag gcggaacgca aactgatgtt tgacgcaggg 2200981 aacgactcac ttgcccaatg gtaccgttcg ccgttgcggt gaagaacagc ctcttcctga 2201041 agatactcaa gaatatcact gacttccatg gctccaaatt cttcatcagc tctaaaagga 2201101 agctcataag ccgcacactt taagtggtct actaaaataa tcaaattctc cggattgatt 2201161 cttgcagatt ccggcgaacg attaaagaaa tattcaggat gccgcacaat atattggtca 2201221 atcggtgttg aattggctac catgataatc aaagattcac cgtgtcttct gccggctcgt 2201281 cccgcctgct gccaagcact tgcaacactt ccgggatacc ccgtcattac acacacttgc 2201341 agctggccga tatcaacacc aagctctaag gcattcgtac tgaccactcc taaaatgtcg 2201401 ccttctctca gtcctctttc gatttctctt cgctctttcg gcagatagcc tccccgatag 2201461 cctctgattg attttgttcc aatctctttt ttcacaagct cctgaatatg gcttaaaata 2201521 atttccaccc gaactctgct tctggcaaaa acaatggtct gcactttgtt tttaaggaac 2201581 tctttcgcca gttcattcac ttctgcggtt gcgctccttc taatattcag cggtttgttc 2201641 acaattggcg gattgtaaaa cacaaaatgc ttgcgtccgc tcggtgcgcc gttgtcatcg 2201701 accagccgca tcggtttgcc tgtcagctgc tctcccaatt cctttgggtt ggcaatcgtt 2201761 gcggaagtac aaataaaaac tggatcactt ccataaaacc ggcagatccg cttcagccgc 2201821 cggatcacat ttgccacatg gctgccgaac acacctcgat acgtatgaag ctcatcgatg 2201881 acgatatact taaggttttc aaacaaactg acccatttcg tatgatgcgg tagaatggca 2201941 gaatgcagca tatcggggtt tgtaatgaca atatgacctg cttttctcac cttttgtctg 2202001 attgccggag acgtatcccc gtcatatgta aagcttttaa tatcaatgcc catttcatca 2202061 ataatttcat ttagctcgct cttttggtct tgtgccagcg ctttagtcgg aaataaatat 2202121 aacgcccggt ttgtttcatc ttgggcgatg gactgcagga ctgggaggtt gtagcataac 2202181 gtttttcctg atgctgttgg cgttacggta acgatgctct ctcctttttg cacatattga 2202241 aaagcggaat attggtgagt atatagttca tcaatgcccc ttttcgaaag ggccgctttg 2202301 attctctcgt ctatactttc gggcataggc cttgtttttg cttcccgagg ctcaatttca 2202361 tgccaattca caacgttttc atttcctttt aaatcagaaa tgagttcagt cagtgatttc 2202421 tttttcattc tttacacctc tttgtcaagt acagtttacc gaatatttgt ttgcatggct 2202481 aggtgcaaat tttatacagt tgaataaaaa aagcaaggca tacgccctgc ttatttcgct 2202541 tttattgtaa agagctttga ttcgccttta cgagcagcct tttcgcctgc cgataccatt 2202601 gatcctacag cctcaccatt cattataacg attgggatga ctgtgctgct cgctttttct 2202661 tttattaatt ccaaatcaca tgtaatcagc gggtcaccga ccttcacttt atccccttct 2202721 ttaatgtggg cagtaaatcc ttctccgttc atattgactg tctccagccc gacatgaatt 2202781 aacagctcaa ttcccgagcg agtccgaatg ccaacggcgt gtttggtgtg gaaaatctga 2202841 atgacttcac cttcagcggg agaaacgatt tcaccgctag aaggttccac cgctattcct 2202901 tctcccatca ttttctgtga aaaaacaggg tccggtacat ctgacaggtc cattactgta 2202961 ccgtctgccg gagaataaat aacctcttct gtcacctttt cctgaatttt gcccattccg 2203021 aataattttt tcagcaatgt attttctccc ttctcattca cttcaaccgt tatcccttca 2203081 ttcaccacta tttaaccaca ctttcaattt tgcttcaatt tataacaaca tctggcatag 2203141 acgcataatc tggttaaaaa aggcggtggc gatattggaa ttccatgatg acaaaaagaa 2203201 cgaactgcaa aagaaagaag aaatcataac ggaggcaatc gacactcttt ttcaatcctc 2203261 agcgttcggc aaccttataa acggatttca gaacctaatc aactcgagtt taaaggatgt 2203321 gcagacgacc atacatgtca gagaaagaga tactgggctg tatatcgata ttaccattcc 2203381 ggcgacgttt cgagatggcg agatcgtcgt tgatgttaaa tcgaggtatc tccatgtaac 2203441 actccaagaa aaacagaaac accaaaatga ggctaccttt acaagcatga caagaacggt 2203501 tcagctgcct tatgaagttc gccaagaaga tatggaaacg tcttggaacg agcagacaat 2203561 gacacttttc tttccaaaaa ataagcatga atgaacgatt cattcatgct tctatcattt 2203621 aaaaaagctg gtaaatccct ttattaaaga tccgacctga ttcattgcac tcattacttg 2203681 acctgtcgta tccatcattt tattaaaatc aaattgccca ttggcttttt tgaactgcga 2203741 cataatgctt tgaaattgtg aaggctgctg ttgattaggc cttgggatag gataagggtt 2203801 agaaaataca ggcggctgca taggcatagg ctggatcgga gcataaggct gataataatc 2203861 ctgctgtcca taatgctgct gaggcagttg ttgctctaaa taaccgggtg cagcctgctg 2203921 ataatatcct tgcatatgct gaggataata atagcccatt tgccgaggat agcttcgaga 2203981 gctcccgttc attgcgattc ccccctaaac acaacatatt tctcttctat atatgtatga 2204041 atgacttcta ttgtttgtgt cacaagtgat gattagcatt tgtcaaattg tgtcgaaagt 2204101 ttaaattttt taaaaacaga aaaaagtcga atcattatgg taccatattt tcaatacaga 2204161 tgagagggga tgcaccataa tgaacgtatc atacttaagc aaacgttttg cagaaatgaa 2204221 gaaatatgaa acagactgta tgaataaact gatggacttt gccaagttcc tctatattca 2204281 aggacatctc agcataactg agtttcgtaa cagtatgaag gttctcgaag caaatggagc 2204341 agaaagcccg gcatatgaga tgaattaacg tccggccccc tataaaaacg aaaagaagac 2204401 agccttttac cggctgtctt ctcttgcaat ttcatccttt actgcgtgca atgtataaag 2204461 gactgactca gtgatgtcct tgaatcgttt tttatgaata tgatgaacat aagattgaag 2204521 gaccaattcc aggaaattat cctttacggc ctcaatttgc tctttatgca catattttgg 2204581 ccggcggact tttatcaatt caagagcacc ctctgcccag cgagcagcca gttcatcatt 2204641 ctcttcaact gcaggcttta tcgtctcaaa aaaatcataa gaatgattac tgttttttcc 2204701 ttcctgatac cgatcagcgc ctttttcagc aacttcaatc atttgctcgg tcatttccag 2204761 caaagtttgt gatagcaata tctttcacct caatgcctat cgtaccaaat ttcactcaca 2204821 aattcagccg atgcggtata ccttctcaaa cgcatacctg tgttcaggcg attgatacag 2204881 ctcatttata caaatatgaa gatctatgat ttcttcttcg agcacactta ggcgatcgtt 2204941 ctccgtttcc cgcatctcag cctctaatgc atttacagaa tgattcaggc tttgctcagc 2205001 tcgcgttaat tcatcttcta tatcagaaag catacggaga atatctgtct tgcatacata 2205061 accggacatt cgtgtacctc cctttccttg tctctcccgg ttaacattct ttgctctcaa 2205121 ggctctttcc ttcctcatga caaaactaga agcaaatcgc caaacaaaca ggtattccac 2205181 gaaaagctga agttttcgac aaaaacaccc gcaaaaattg tatgatcctc ctcattaatg 2205241 caaacgatac ttgtgaggag gtgccgtatg aaaacaagac cgaaaaaagc cggccagcaa 2205301 aaaaagactg aatcaaaggc aatcgattct ttagataaaa aattaggcgg cccgaaccgc 2205361 ccttctacgt aagaagcaag gaatttcctt gcttctttat tttttcagcc actgctccac 2205421 cgcaaaaagc gcatgaagct ggcgcttttt atgtaaatac cagtctgtca attcaatctg 2205481 cttcggcaat tcctcgcgcc taaagaacgt tttctttatc tttccatgaa accaatctgt 2205541 tttcgttccg tctaatgagt ggattaactc agggtagcat gtccttagca taggagatgt 2205601 tctttttgta atcccgatca tcttttccat atcaaaacgg gaacctgtgt gcggcactgt 2205661 gtgcaaaaag tgataaaaag aggagaacaa ttctggcttg aacagcaatt gagacagctg 2205721 ctttcccagc cttatccttt cctccgcctt tgaaaagcgt ttcactgaaa tgccgtaaaa 2205781 aaacccattt gaggaaggaa aaataacggt gttaaaatga aaccagtcac ttaaataaaa 2205841 aggaatcgtg tcaaaaacat tctttttaaa cgaaggattt tgtataatag gtgtttggat 2205901 agtgttttgt tcatttataa tgagggcata cattagccgc tccgtatttc gctcatgcca 2205961 aaaacgggtc cattcttccg acataaattg tgagacgcca aacacatgca gcagatgaaa 2206021 cagcggtttc ccaactcttt ttgaccagtg gtataaaaga agctgcggat aggcatccga 2206081 aaaaataagc cagttcgctc tttcataggc taaaaagaac catttttgct gtctctcacg 2206141 gagtccaagc tgaaacagac tgccttttaa gtcagtcatt gaccagccgg cattacgaga 2206201 aacgaaagaa gccaaaagcg accatttgat ttccggatga cggtcgtaaa atgctttata 2206261 agcatttgtt cttgaaatgt tatccgcgtt tttcattttt gtctgccgct caatccggct 2206321 cagaagcttt ctgatggcct gttgttcttg cacgttcatt cacttccgtc atgattagtt 2206381 taataaggag gatgagaaag tgattcggta tcctaatgga aaaacatttc agccgaaaca 2206441 ttcggtttca tcccaaaaca gtcagaaaag ggccccgtct tacagtaatc gcggaatgac 2206501 cctcgaagat gacttaaacg aaacgaataa gtattatctg acaaaccaaa ttgccgttat 2206561 acacaaaaag ccgacacctg ttcaaattgt aaatgtccat tatccaaaaa gaagtgccgc 2206621 agtgattaaa gaagcttact ttaaacaatc atcgacaaca gactacaatg ggatttacaa 2206681 agggcggtat attgattttg aggcgaaaga aacgaaaaac aagacctctt tccccctgca 2206741 gaattttcat gaccatcaaa tcgagcatat gaagcaggta aaggctcaag acggtatttg 2206801 ttttgttatt atatccgctt tcgaccaggt ttattttttg gaagccgata agctgtttta 2206861 tttctgggac agaaaagaaa aaaacggcag aaaatcaatt cgaaaagatg agttggaaga 2206921 aacagcttat ccgatttctc ttggatacgc acccagaatt gattatatta gtattattga 2206981 acagctttat ttttcgccat catctggtgc gaaaggttga ttaacgaaag gttgagatgt 2207041 tatgtcagat caatttaaca gccgtgaagc tcgacgaaaa gcgaacagca aatcgagtcc 2207101 ttcaccgaaa aaaggcaaga aacgaaaaaa gggcggattg tttaaaaaga cccttttcac 2207161 tttactcatt ctgtttgttt taggcgtagt cggcggtgct gttacatttg ccgtcatggt 2207221 ttctgatgcg ccgtcccttg atgaaagcaa attgaagacg ccttattcat caacgattta 2207281 tgataaaaat ggaaaagaga tcgccgaagt cggcgccgaa aaacggacct acgtctcgat 2207341 agatgaaatt cccgatgttg taaaagaagc ctttatcgcg acagaagacg ctcgttttta 2207401 tgagcaccac gggattgacc ctgtccgtat cggcggtgca ttagttgcca actttaaaga 2207461 cggcttcggg gctgaaggcg gaagtacgat cacccagcag gtcgtcaaaa actcccttct 2207521 ttcacatcag aagacgttga aacggaaggt gcaggaagta tggctttcga ttcagctgga 2207581 gcgcaattac tctaaagatg aaattttaga aatgtattta aaccggattt atttttctcc 2207641 tagagcatac ggaatcggaa aagcggcgga agaatttttc ggcgttactg atttaagcaa 2207701 attgactgtc gaacaggctg cgacgcttgc aggaatgccg cagagcccaa cagcgtacaa 2207761 cccggtcaaa aacccggata aagcggaaaa acgacggaac atcgtactca gtctgatgaa 2207821 aaagcaagga tttatttctg attctcaata taacaaagcg aaaaaagtgg cagtgaaaga 2207881 cgaaggcgtc gtgtcacaga aggaatatga aaaagcaagt acaaacaaat acagcgcatt 2207941 tgttgaagag gttatgaagg aaattgatga aaaatctgat gtcgatccat ctgctgacgg 2208001 attaaagatc tatacgacat tagatacaaa agcacaagat aaactagatg aattaatgga 2208061 cggagacacc gtcggattta ctgaaggcat gcagggcggt gtgacgcttc tcgataccaa 2208121 aaacggagaa gtccgagcga ttggtgcggg acgcaatcag cctgtcggag gctttaacta 2208181 tgctactcaa actaaggcac agcctggttc gaccataaaa ccgattttgg actacggacc 2208241 agttattgaa aataagaaat ggtccacata cgaacaaatt gatgactcag cttatacgta 2208301 ttctaacgga aaaccgattc gtgattggga ccgcaaatat ctagggccta tctcaatgcg 2208361 ttacgctctg gcccaatcaa gaaatatacc tgctttaaaa gcattccagg cagtcggtaa 2208421 agatactgct gtagactttg caaatggact cgggcttggt ttaacaaaag ataatgtaac 2208481 agaggcctat tctattggcg gtttcggtgg gaacgatggt gtttctcctc tgacaatggc 2208541 aggtgcatac agcgcgtttg gaaataacgg aacgtataat gaaccgcatt ttgtaaaatc 2208601 tatcgaattt aacgatggca cgaagcttga cttaacacca aaatcaaaat cagccatgag 2208661 tgattatact gcgtttatga ttacagatat gctgaaaaca gctgtgaaga caggtactgg 2208721 acagcttgca caagtacctg gtgtagaagt tgcaggaaaa acaggaacga ctaactttga 2208781 tgataatgaa gtcaaaaggt acaatatcgc tagcggtggc gcccgagatt cttggttcgt 2208841 tggctacaca ccgcaatata cagctgccgt ctggacggga atgggagaaa acgaggctgg 2208901 aaagaaatca ctttcagctg aagagcaaaa agttgcaaag cgcatcttcg cccagctcat 2208961 cgccgatgtc gatgacggaa gcggatcatt tgagaagcct gacagcgtag tggaagccac 2209021 cgtagaaaaa ggttctaatc cggcaaaact ggcagggcca aatacgccaa gcgataagaa 2209081 gctcacagag tactttgtta aaggcacagc tccttctact gtttctaaaa catatgagaa 2209141 agaagaaaaa gaggaaacag ctaaactgtc tggtttaaac gtgaaatacg ataaagacaa 2209201 tcaatcttta acgttaagct ggaattacga cggagatgcg acctttgctg ttaagcaatc 2209261 tgttgacggc ggcagctact cggaaattca aaacagctct gcaaaagagg cagttatttc 2209321 gggtgtgcag ccaggatctg tatacaaatt cgaagtaaca gccgtcagtg atgatggcaa 2209381 aagtacagct tccacatctt atgaggtgcc aaaagctgaa gacgatgaag ataaaaaaga 2209441 ccagcaacaa acggatgatg aaaaacaaga tgatgagaag actcaggatg atacacaaac 2209501 tgatgattct caaaaagatg acggtcagac ggatcaagat cagacagatg attcaacaaa 2209561 cgatcaagac aaaaaacaag acaatacgaa caccaatccg tccgacaaca ataaccaaga 2209621 ccaatcaaac gataatgata acgacaacag taacaaccag gatacgtcgg atggtgattc 2209681 gaactctggt aagaatgatt caacaggttc tgacacgaat aaaaataaaa cagacacatc 2209741 taataaaaca caaacaaact catcatccat tgaaaaaaca aattaaacaa aaaagccgtc 2209801 acctttgggg tgatggcttt tttggtacac aataaaaaac ctcccgtttt aacaggaggt 2209861 tttatcgatt catcgcatga tatttataaa aatgcttttt catttcggta atcagctcat 2209921 caagctgaat aaagcaatgg tattgggtcg gcttaagaag aataaattcc actcgttcag 2209981 cccaattaat cggctttgcg ggatatgatt tctccctcag ttcttgccaa tcgagcgatt 2210041 tcaccggctc acctgctgtc caatgtaacg aagccagcaa acacacaatg ccctttaaca 2210101 tttcgttttg gtcacatctc gattttcgtg tttgaaagac tgggagaagt gatgctttga 2210161 tgtcatccca cacttcaaat aaaagcggaa cgtatttccc gctgtcctcc catggcaaat 2210221 cgccttgtaa ttccgtgcag aaatcaaaat acacgggatt ggtctgcaag gttttcttca 2210281 tatccgagga actcttctgg ccaagactgc gcaagtattg ctcataggaa gccaacactt 2210341 cttttgcttg cgtcatcgtt tcaccagtcc ttttttatcc ctcttctgcc cttctctgca 2210401 caaagaaagc agcggacact ccgcacagcg cggagattgg gctttacagt gatatctgcc 2210461 gaagaaaata agccggtgat gcgtaacgga ccaatcttct ttgggaacct tgcgcatcag 2210521 cgtcttttca acttccagaa ccgagtcctt ccaccggcaa atgcccaatc gtttgctgac 2210581 tctctccaca tgggtatcta cggctatggc cggcacgcca aacgcaacgg ataccactac 2210641 gtttgcggtc tttctcccga cccctggcag tttgacaagc tcatcgcggt ctctcggcac 2210701 ttctccgccg taatcttcaa taatcatttt actcagcttt tgaatatttt tcgctttatt 2210761 acgatataaa ccgattgatt taatatcctg ctgaagctct tccagcggaa cagccaaata 2210821 gtcttccggc cgtttatatt tttggaataa tgttttggtc actctgttta caagtgcatc 2210881 tgtacattgc gcagataaag caacagccac cactaattca aaaggattgg aatgaaccag 2210941 ttcacactcc gcatgaggaa acatgtcacc tatcttgtct aaacagaatt caatttgttt 2211001 tagatttaac acgattgtca ccttttcact ttattgttca agccaattgt aaaaaggaac 2211061 ctgcctttta tactcttttt gcggttcatt ctgctttgct tgtacacgcc ggaatttttg 2211121 gctgtgtatt tttgcctgct ccacagtttt aagcccattt ttcttccatt caaacaaaat 2211181 ccggtcaatg tagcggaaac tgagttttcc tgatagtaca gcctctttta acgcgtgttt 2211241 gatcagttgt gcgtcatgct gatcctggtc ctgccagatc gccagcgttt cacactccaa 2211301 aggcgataac ggtcttgcga actcttcctc aaaaatggta taaaggcttt tttgttcccc 2211361 ttctgctttt ctttcctgtg tttgattctg tgcaagctga atatactcgt acagcttgcc 2211421 ccataaaggc tgaagagaat atttctcaaa tttgatgccg ttttgatcct cgcattcttc 2211481 aataaacaga aagccttttt gaataaacat ccgcaatctg tttgtacatt cttcaacaga 2211541 aattgacata ccttcctgca gctgattcgg tgtaggaaaa tatgatcctt tttctaaatg 2211601 cattttaatt tttaacagca gaataagttc tgtttcatta agcccaagct gtttataatg 2211661 cgtgagcaga agattgggga tggttgatgt tccctgctcc tgcatatcaa taaattgctg 2211721 ttttttcatc gtcacacctc ttactgtaaa ggattgtgat tgccccttta ctgtaaaaag 2211781 tctcccttgc aggagactct tttttgtttc atttgaatgt attacggata cagacggttt 2211841 aacagtcttg ggaacggaat cgtttcacga acgtgaggcg ctccgctgat ccaagctact 2211901 gtccgctcta atccaaggcc gaagccggaa tgaggaactg atccatattt tctaagttca 2211961 gcataccatt tataagcgtc agaatccagt ccatgttctt taagacgcga ttccaaaagt 2212021 tccatatcgt gaatccgttc agacccgccg atgatttctc catagccttc cggcgcaatc 2212081 aagtcagcgc aaagcacaac gtcctcacgg tcagaagccg gctgcatata gaacggtttt 2212141 aaggacgtcg gatagcgagt gatgaatacc ggtttgtcat aatgttcagc aatcgctgtt 2212201 tcatgaggcg ctccgaaatc atctccccac tcgatatcgt caaagccttt ttctttcaga 2212261 aattcaatcg cttcatcata cgtaattctt gggaacgggg ctttgatttg ctcaagtttt 2212321 gacgtgtctc ttcccaatgt gtttagttca attttgcaat ttttaagaac tgattgcacg 2212381 atgaaagaaa cgtaattttc ctgtacttga aggttttctt caaattctac aaacgccatt 2212441 tccggttcga tcatccagaa ttcgattaag tgacgctttg ttttagactt ttccgctctg 2212501 aatgtcggtc cgaaagagaa tacttttcct aaagccattg ccgcagcttc catgtagagc 2212561 tgtccgcttt gagacagata tgcatcttca tcaaagtact ttgtcgcaaa gagttctgtt 2212621 gttccttcag gtgcgcttcc agtcaaaatc ggcggatcca cttttacgaa gccttcgtta 2212681 ttaaagaatt cgtaagtcgc gcgaatgatt tcattacgga ttttcatgat cgcatgctgg 2212741 cgctttgaac gcagccataa atgtctgtga tccatcaaaa attccgttcc gtgttctttt 2212801 ggtgtaattg gataatcggt cgcttcgtga atgacttcaa tatctgtcac agcaagttca 2212861 tatccaagcg gagaacgctc gtcctctttg acaatccctt ttatatagag cgacgtttcc 2212921 tgcgtcactg atttagctgt ttggaaaatg ctttcttcca cttccgcttt tactacgaca 2212981 ccctgaataa aaccggtacc gtcccgaagc tgtaaaaacg caattttccc gcttgaacgc 2213041 ttattagcga cccaagctcc gatcgttact tcctcaccta cgtgcttgta cacttggttg 2213101 attgttgttt tcaacatatt tccctccaaa acaagaaaga cattcggaag ctcattgccc 2213161 cgcgaactct tttatcatca ctttattata cccgctctta actaaccggg tcaatgcaga 2213221 taaaaagcgg cttttctgtc agccgctttt tgatctgtta gctatgtttt tctacaaaac 2213281 gcttgattct ttcaatggct tcttcaagaa gatctaacga tgttgcataa gaaagacgga 2213341 cattctcagg agagccaaat ccggatcctg gaacaatcgc aactttttcc tcctcgagaa 2213401 gcgctttaac aaattcatct acatctttga aaccgcaaga ttgagctgcc tcttttgcat 2213461 ttgggaacaa gtaaaaagca ccttccggct tcacgcagct gaaccctggg atttctatga 2213521 gctttgcata gatcgtattt aatctatgtt caaatgcttc tctcatttct tccaatggct 2213581 cagaaggccc gttataagca gcaatcgctc cgtattgtgc gattgatgtc gggtttgacg 2213641 tgctgtggct tgcaaggttc gtcatcgctt taataatgtc ttcagagcct gccgcataac 2213701 cgattctcca gcctgtcatg ctgtgggact tcgatacgcc gtttataatg accgtttgct 2213761 ctttcagtct gtctgacagc tgtgcaatgg aaacatgttt ctttccgccg tatgtaagtt 2213821 tttcataaat ttcatctgac acaatcaaga tatcatgttc aaggcacact tcaccgagcg 2213881 cagatagttc ttcttccgta tacatgacac cagtcgggtt gcttggagag ttaataacga 2213941 ttgcttttgt tttttccgta attgcatttt tcagctgctc aggcgaaatt ttgaagtgat 2214001 tttcctcaag cccttctaca taaacaggct ttccgccagc gagtttcacc tgctccgggt 2214061 agcttaccca gtaaggcgtt ggaataataa cttcatcttc ttcatccaaa atcacttgga 2214121 aaagggtata cagagcatgt ttggcaccag tgcagacaat aatttgagac ggtttgtatt 2214181 caatattctg gtcgcgttta aatttctctg caatgctgtt tttcagttca gccaaaccac 2214241 cggaaggcgt gtatttcgta tggccctcgt tcatcgaacg cacagcggca tcaataatat 2214301 gctgcggtgt attgaagtca ggctcgcctg ctcctaagcc gatgacatca tggcctgcgg 2214361 ctttcagttc tttcgctttc gctgtgattg ccagtgtggt tgatggtgtt aatgcggata 2214421 ctctttttgc cagtttcaac ttgaactccc cctaattcgt cttaaggcgt gatatttttg 2214481 agaatctttc cagttgtaaa gtccacataa cttaaactgt attgcccttc tttgtctaag 2214541 tacgtcactt cccaaagcag gacgtttcct tctcttgcca gatgaacctc tttttgcttt 2214601 gaaaccagcc cttcatcctt tatgattttc gccgctttgt cttcagagat tccctctttc 2214661 gcttcttttg agagaatttt tgctttttta tcagcaggaa cccagacata taatgcagtg 2214721 ccttttttat ccgttccctt tacaacataa tatttttctt ttccgacaaa tgtttcgact 2214781 tgatcaacat gggcgagatc ggtttctttt ttagcttcag cagctgctgc ttcgtgcccc 2214841 tcttcctttt gtgccatggc tgatttataa atgcttgccg agacaagaag tactgctaaa 2214901 aaaataatac caaaaatgac ggtaaatatt aatgcttttt ttctcatctt ctcacctacg 2214961 tacgataaat ggtaaaaacg gcttggtttt tgttttcttc atccagcgca aggccgaaca 2215021 tcagattgtc tcttttcagt gtacgattca atgtgtccac aattttatac agatcatcag 2215081 aatgctctac attaattgtt gaaagaattt cgattttact ttccattttt tcatcctcca 2215141 gtttgaacaa atattgttag tcatactcca tttcaggaca cgccatacta gtatcacaga 2215201 gcgggaaatc cgcttttaaa taaaacacca tcctactccc acaccgcaaa agccgcttta 2215261 tgcggctttt attctttttc ccctgcaaca taagcttcaa gctcgctgtc agtcatttcg 2215321 gatactgagg ttgtcggcaa ggcatcaaga aacagccggc cgtaaccagc ggttttaatc 2215381 cgtctgtcca atataataat cgttcccttg tctcccgcag aacgcagcaa gcgtccgatt 2215441 ccttgcctga aggtcagcac agcttccggt aatgacactg tttgaaacgg attctttcct 2215501 tttttgcggg caagctcaca ttttgcagca tgaagcgggt gatcagggga ccggaatggg 2215561 agcctcacga tcattactgt cgtcagctca tcaccaggga aatcaacgcc ttcccaaaaa 2215621 tgatttgttc cgagcaggat cgcctgattg gatgttttaa aagtcttcat cagtttgccg 2215681 ggacttccgc ctgtaatccc ttgtgccaag agctgaatgc cggaagcact catgttatgc 2215741 ttaagctcct ggtgaacctt tttcagcata tcatgggatg taaacagcac aaggatttta 2215801 ggctgttttt cctttgccat cagttcgata taacgggctg tatcctgtat aaattcaggt 2215861 tgccctgtat cctgaattga tttcatttct tttggaatca tcacctgcat acgctcatcg 2215921 taagaaaagg gtgactcaat tctcattgtc cgcgggaaaa agtcactcag tcccagtcgt 2215981 tcaatcataa attgaaaaga accttcgact gtaagagttg cagatgtcag caccacacta 2216041 tttttgcgcg cgaaaaactg atcagccaga agttcaccag gttcaagagg ctgtgcgtaa 2216101 atggccactg catttttcgc accctttgca tctatttcaa tccaaaccgc ttcatcgtca 2216161 tcagagccaa agaagagctt ctgcaacgtc tgacagtaat gctgcaagcc tttcatgctt 2216221 ctttggtatt catcggctaa aaagacggtt ttgctcttca tgcccttcaa atgtttttcc 2216281 ataagggatg actgcgcctc aaaaagctgc tgcaaatgtg tcagcatgga acaaagcctc 2216341 tccgcaccat ctgttaagat cgaccagctt ttatcctggc tttctttgtt caccttaaac 2216401 actagacggt ttaagtcttc tttaggtttt cttcgtttga caaaagaatg tacagagcta 2216461 aagaaagcat cactttctgc ttgaacgtgc tgaagccact cttccaattc gaaaaatgaa 2216521 tcaaccggca ggctgtttcg ctggaatagc tgtctcatct tttttagaag tccctgctcc 2216581 ttcagagtgc cgattctgct caatttcgta tgcaattcta tgtacgtggc tcttttccct 2216641 aaatgttcgc ttgccgcacg ttcaaaatgg tgtgcttcat caataataaa tgtgccgctt 2216701 tcgggaagcc tttttttatg gctgccttca tcggtcagca aaagagaatg attggtgatc 2216761 accaaatcgg aacgcatagc aatctgtttg gcccgctcgt aaaaaccgat cacatgctca 2216821 ctgcgacttc ttttatagga gtcatcgtca taagccaatc tgtcccacag caattttccg 2216881 cctgaaggca aattcagttc cgctacatct cctgtatttg tctctgtcag ccaaacaaga 2216941 agctgtgcct ttgtcagtac ggcatcataa ttatcatctt cttcatgaag cacctgctca 2217001 aatttataca ggcataaata atgcgattgc ccttttaaaa tcgccgctgt taccggaaat 2217061 ggaaacagat cttggacaat cggcaaatcc tttgtgagaa tctgctgctg taaaagcgtc 2217121 gaatacgtgc tgattatgac cggctttttt gatttcttgg caaaaagcgc agccggaata 2217181 agatagccaa tcgtttttcc gatgcctgga ggagcttcaa tcagcgcatg ctcacgattg 2217241 gcaaacgcat cagccacctc tctcatcatc atcatttggc cgtctctttt ttcataccca 2217301 ggcattaact ctgacagcgc tttttcattt cccgcttccc agctttcgat ctcaaatgag 2217361 aagttctcgt cctcatttat acgaacatcg atagcttcag gttctctgac agaaaacgaa 2217421 gaaaagcgcg tatagcccgg tatctcggta tgtctgtttt cattaatgaa catatccaac 2217481 aaatgcgtca gatcactgat gaaatgctgc gaaagccttc ttaactgctt taatgtcgga 2217541 taaggaagct gccgcagctt ttcaaggatt tccaaaaaaa taagccctgt cacttcagca 2217601 tcgctgtcag cccggtgcgg ctgatcatgc cgcagctgaa gctcctcgct taattccgtc 2217661 agcttatacc cttcaaatcc cggaaaaaca atgcgtgaga gctcgacagt atcaagcact 2217721 tcacaatctg ggagctgaaa gcccgcctta tgtagctcat acttgacaaa tccaaggtca 2217781 aaatggatat tgtgggcgac aaaataagcg ccgtcaagca attggaatac ttcttcagca 2217841 actgcttcaa atggctgttc attctcgacc atttgattag agattccagt aagctgctca 2217901 ataaaagcag ggattgattt atttggatta atgtattttg aaaaccgctc agtaatttgt 2217961 ccattttcga ttacaaccgc tgcgatttgt atgattttat cgcctttctt cggcgaattc 2218021 cctgttgtct ctacatctat aacaacgaac cgttgcttat tcattaaaat ggacacctca 2218081 attcttgcat acgacaaaag tgtaacacgt tttgtacgga aatggagcgg caaaaccgtt 2218141 ttactctcaa aatcttaaaa gaaaaccccc gataaagggg gcttttcttc tacaaaattg 2218201 tacgggctgg ttcgttcccc agcatttgtt caattttgtt ttgatcattc agaacagcca 2218261 ctttcggctc atggcttgcc gcttcttgat cagacatcat tttgtaggaa ataataatga 2218321 ccttatctcc ttcctgcaca aggcgtgcgg ctgcaccgtt taagcatatg acgccgcttc 2218381 cccgtttacc aggaataata tacgtttcaa gacgtgctcc attattatta ttcacaattt 2218441 gtactttttc attaggaagc attcccacag catcaatgag atcttcatca attgtaatgc 2218501 ttcccacata gttcaggttt gcttccgtaa cagttgccct gtgaagtttg ccgctcatca 2218561 ttgttcgata catattatat tctctccatt tctcgaatat caataatgat attatctatt 2218621 aaacgcgctt ttgaaaaagc aactgcaaca gcgagaatca tctttccagc aatttcattc 2218681 acaggctcga gttccggata ggaataaagc tctacatagt ctatggttcc gctagtcgtt 2218741 tcaatgatat cttttgcagc ttttatcacc gcttcaggat ctctttcacc ggcttggaca 2218801 agttccgcac ttgtttgaag ggcccgatac agcttaggcg cttcttttct ttcctcagct 2218861 gttaagtata cattgcgaga gcttttggct aagccgtctt cctctctgac cgtatcgaca 2218921 ggaaccaatt caatatccat gaagaagtcg ctgattaacc catcaacaac agctacctgc 2218981 tgcgcatctt ttaaaccgaa ataggcacga gtcggcttga ctagattgaa aagcttcgtc 2219041 agtacgatcg cgaccccgtc aaaatgtcct tctcttgagc gcccgcataa cacgtctgtg 2219101 cgtctttcta catgaatcgt gacattcttt tcaccgggat acatatcatg agcatctggc 2219161 gtaaaaagaa tatcgactcc ggcgttttct gcaagagctg catcccgctc aatatcgcgc 2219221 ggatatgctt caaaatcttc attagggccg aattgtgcag gattcacaaa aatactcata 2219281 ataacggcgt cgttttcttg tcttgctttg tctgctaagg ttaaatgccc ctcatgcaga 2219341 aaccccatcg tcggaacaaa tccgattgac ttgccctctg aatggtattg ttttatggct 2219401 tctttcagct gtgaaatatc agtaatctgt ctcatcttat tttcccccgt acaagccgtc 2219461 aagcactgtc tggttcattt gaaaggaatg cttttgttca gggaaagcac gatgtcttac 2219521 atcctgaaca tatccgctga ttgctgtttc gatggtttca tcaatgcgcg tatattgctt 2219581 tacaaattta ggtgttctct caacaccgtg gccgataata tcatgataaa cgagaacttg 2219641 tccgtccgct ttcacaccag ccccgattcc aatgaccggt atgcttagcg tctcggcaat 2219701 tttggctgtg agttctgccg gcacacattc cagcacaagc atcatagctc ctgcttcttc 2219761 gcattttata ctgtcttcta ttaatttttt ggcgctttgt tcgtctttgc cctgtacttt 2219821 atagccgccc agtacgccga ctgactgcgg tgtcaaacct aagtgactga ctactggaat 2219881 gcctccaagc gtcaatgcgc gaatggattc aaacacgcct tctccgccct caagcttcag 2219941 tgcgtcagct ccgctttcct gaacgatagc cgctgcattt ttcagcgtat cttccttaga 2220001 caggtgataa gacataaacg gcatatctgt cacaataaag gtattcggcg cacccctttt 2220061 aacggctttt gtatgatgga tcatgtccgc aactgtcaca ccgacagttg aatcaaggcc 2220121 gaggacgacc attccaagtg aatcaccgac taaaatcatg tcaactcccg cttgttcagc 2220181 aagtttagct gccggataat cataagcggt cagcatgaca atcggttctt cagactcctt 2220241 catttttaga aaatccagtt ttgttttcat gttttctcct cctcatgttt agaggagatg 2220301 atctgccgtt ttcttctgca agccaaaaaa ccttccgtta caacgagaag gattcttcac 2220361 tttctaaagt tcggcgagtt tcatccctct gtcccagtcc ttttttggat caaggcagac 2220421 tgctgcaatg tctatctatt ttaataatag gtgcagttcg caggcgatac tgcccaatgg 2220481 aagtatacca aaatcaacgg gcttgtacca acacattagc ccaattcgat atcggcagaa 2220541 tagatttttt taatgccttc gttcgtttct aaaagcagaa cgccttcatc atctatacct 2220601 aacgccttac cgtaaaaggt tccgtttaac gttctggctc tcatattagt gccaataccg 2220661 agcgcatagc tttcccataa aagcttaatc ggcgtaaatc cgtgcgtcat ataatcccgg 2220721 taccgtttct caaagcatag taaaatatgc tggatgacgc cggcccgatc aattttttcc 2220781 ccagcagctt ggctgaggct tgtcgcgatg tccttcaatt catctggaaa atcattaggc 2220841 tgctggttaa cgttaatgcc gatcccaatg atcactgaac gtacgcggtc ttcttcagcc 2220901 tgcatttccg ttaggatacc gactgttttt tttccgttaa tcaaaatatc atttggccat 2220961 ttaatatccg tttggatgcc tgctgcctct tctattccct gcacaacagc tactgcagca 2221021 agcagagtca gctgcggtgt tttttggagc ggaatgtcag gccgcaaaat caggctcatc 2221081 caaacaccgt ttccttcttg agaatgccat accctagaca ttcggcccct tccggctgtt 2221141 tgtttgtcag ccaccacaag ggtgccttcc ggtgcgttat tattcgcgag ctcatgagcc 2221201 gttttttgcg tgcttgaaag aacgtcatgg taaataagat gctggcccat cacttccgtt 2221261 tttaatccaa aacgaatttc gctttcactg agttttccgg gttttttgat gagccgatat 2221321 ccttttcttc taacggcttc tacttcataa ccctctttcc gaagctcttc aatatgcttc 2221381 cacacagcag ttcttgaaca gccgagagca tcactgattt tttggccgga aataaattca 2221441 ttgccggcct gagaaaataa ttcaataagg tcttttctta atgttgaccg catgtcttca 2221501 gccactcctc tatgtgtttc ttttgattgg agagcttccc tgtcacaaca gcctgctcga 2221561 tccactgtaa ttcttctgac acccattttc cggccggccg gtttcgaagc gcaagcaagt 2221621 ccttacccgt gatatcaaga tccttaaggc ttttgatcgg caggttttga taagcgtact 2221681 gaatgtcctt cagtttcttt tcatccagtt tttcgttttg ccgaagctgc gatattttgg 2221741 ccgctgagag cagtgctttt ttcccagctc tgtacattgt cattgcgtca aggctctggc 2221801 caaacgtatc ggcaatgtga atggcttcct tgatcacttt tcccgggagc ttccaggctt 2221861 tcaggaaaag gggcgcgtct ttcaaaacta tgccaaggtt aattaaaaga gcagcccaaa 2221921 gctcctcacg ggatgttaaa gagaagaatg gaaactcact cgttgaaatc aggttttctc 2221981 gtttatgata aaaaccagga agctcttcat acaatctcgt ttgaatgagt gtttgaagcg 2222041 cctggcgaga agctcttccc tgcagcaatt tctcaaactc tatagttttt cgttcgactg 2222101 aaacatggga gaggagtgat ttttctttcg caatggcttc ttctgtttcc ggtgaaagcg 2222161 taaagccaag ctggctcata aagcgtacgg ctctcagcat acgaagcgca tcctcttgaa 2222221 atctatcctc aggctttcca acggttcgaa tcactttctg atcaatatct ttcttgccgc 2222281 caaaataatc aagcaccttc ccgtccgctg tcatggccat cgcattgatc gttaaatctc 2222341 tgcgttttag atcctcttct aatgatgaga taaattgcac ttctgacggt cttctgaaat 2222401 caacataatc agattcagtc cggaatgtcg tgacttcata ggtttcatcc tcccagagca 2222461 caataatggt cccgtgctct ttgcctacat caacagtccg ctgaaacagc cgttctactt 2222521 gatcaggtgc cgcatctgtc gcgatatcga catctccgat cgttcgtttc atatagctgt 2222581 cacgaactgc gcccccgaca aaataagcct gatggcccgc ttcgattaag atgcggagca 2222641 cgggaagtgc tttgataaaa actttttcca tgtgatcact ccggttctgc taaatcggca 2222701 taaatctgtt catactggct gacaattttt ttagaagaaa attcattttc aagcatctct 2222761 attgccgcct ttgtaaaacg attgcttagc tgttcatctt ctaaaatgct catcgcgcgg 2222821 gctgttgcgg ccgtaacatc accgacatcc accaaaaatc cgctcacatt gttttttata 2222881 acctcaggga taccgccaat gtttgttcca atacaaggca ctccgcaagc catcgcttca 2222941 agcaggacaa ggccaaagct ttctttttca gatagcagca gcttcaaatc gctaatagaa 2223001 taaagatctt caacacggtc ttgatttcca agcattaaga cttggtcttc caagccatat 2223061 tttctgataa gctcgcaggc tgtcgatttc tccggaccgt ctccgactaa aagcagcttc 2223121 gctttcgttt tgccagcgat attgcggaac acacggatga catcctgcac gcgtttaact 2223181 tttctgaagt tggacacatg gatgacgact ttttcatctg gtaaaattcc atgtttctct 2223241 ttaattgccg ctgtgttttt cttcagatac acgcgctcgt ctataaagtt ataaatcgtt 2223301 tcaatttttt tctccggttt aattaaatcg tatgtttcag ccgcaagcgc tgaggagacg 2223361 gccgtcaccc tgtctgatga ctcaatagca aaacggatca gatcttttag agacggatca 2223421 taacctaaca ccgtgatatc cgtgccatgc aaagtggtaa caatgccgat attgcgtttc 2223481 agcatttgtt ttgcaagata ggcgcaaacg gcatgcggga gagcatagtg agcatggata 2223541 atgtctaaat tctcccgttc cgccacctca gcgattttgc ttgccaatgt caaatcatac 2223601 ggaggatact taaaaacagc atattgatta acctcaactt catgaaaatg aatattggga 2223661 tgatatgtat tcagtctaaa cggaatgctt gatgtgatga aatggatttc atgtcccttt 2223721 tcagcaagct gcttccccag ttctgtcgca atgatacctg agcctccaac gctcggatag 2223781 catgtgattc ctatttttag ttttctcatt gttcgccccc aagcacatca tgatcaagca 2223841 tcagcatccg tttggaaaag aaaccttcgg catactccac gcccgcttct ttaccgtaaa 2223901 gcttttctct cgcttcaacg atttcaatat acccattcgt cagaggagta gaaacggaat 2223961 cctttgacgg gataaactgg cttttgtagg cgttgaggct ttgtttcttt gcctctattg 2224021 tatccgagat atcaataaca aaatccggct gatgaaaacc atttatcata taatagtaaa 2224081 ccttgctgac tttatgcgcc ggaaggcttt tttcgtcttt atatttatgg attccggcgg 2224141 aaaagatcgc ttcttccacc agtgcagccg cattgccgtg atccggatgg cgatcctttt 2224201 tatacggcat aaaaaccgct tttggccgac agattctgat gacagtgaca attgaccgaa 2224261 ttgcctgatc actcattatt aggccgcggt ctggaagcgt tagctgaatt cttttatctg 2224321 cgcctaatat gcgggctgct tcagctgctt cttctttacg caaactgacc gtaccgttag 2224381 aagagagttc cgcttctgtc aaatcgcata tcattacttt tttttcctgt ttgacaaact 2224441 tcgctattgt gccgcccatt ccgatctcga catcatcact gtgggcgcca aaagcaagaa 2224501 cgtcagcatt atacattcgg ctcttctccc cgaagaaggt cacggaattc gaaaacacct 2224561 tcatcaagtg tgcgcacaag aatttccgca gtacccatat ttgtggcgag cggaatggaa 2224621 tacacatcac ataaacggat taatgccgag acatccggtt catgcggctg cgcggtcagc 2224681 gggtcgcgca aaaaaatgac aagatcgagt gcattggcag cgatcagtgc accgatttgc 2224741 tggtctcccc ctaaagggcc ggattgaaaa cgttcaattt gaagacctgt cgcctcatga 2224801 attttcaacc ctgtggttcc ggttgcgtat agatcatgat tctttaaaat atcccgatag 2224861 gcagtcgtaa attgaaccat atcctgtttt ttcttgtcat gcgcgatcaa agcaattttc 2224921 attgtttatc cccccgtcta atcaatgata ttttctaaac catacacaag ctgatcaatc 2224981 ttcatgactt gttcgactga cagtttaacg cctgacatga aagaagcacg gttataagaa 2225041 tcatggcgta tctgaagcgt ttggccatcc atgccgaaca tgacctcctg atgcgcgatc 2225101 agtcccggaa gacggacgct gtgcaagcga ataccgtttt gctccgctcc tcttgctcct 2225161 gggagaattt ctttttcatc cggatgtcct tgctgctttt ctttacggac ttctgaaatc 2225221 atttccgctg ttttaagcgc agttccgctt ggtgcgtcaa gcttctggtc atgatgaagc 2225281 tcaataatct caacatcctc aaaatagttg gcagccattt ttgaaaattt catcatcagt 2225341 atcgcaccga gcgcaaaatt tggcgcgatg atggctccga tccctttttc ttctgttaaa 2225401 gatgtgagct cttttaaatc agcttctgag aaaccggttg ttccgacaac tggacggact 2225461 ccgtgctcta atgcaatttt tgtatgtact tttccgattt cgggcgttgt taaatcaatc 2225521 aagacatccg gttgtgtttc tgtaaaacag gcatggatat ctgtgtaaat gaaagcatct 2225581 gactcaacag gcatcacatc agataatttt tgctgatcgt atgtatggtc tatggcccct 2225641 acaaggtcaa aatgtggtgt tcgttctgcc aatttaacag cttcctgccc cattcttcca 2225701 cgcggtcccg caatgactaa tttaattgtt tcgtttgaca tcttgatctc ctctactttc 2225761 cttcttcttt tctggtccag cgatctttat ctcttgtatt aaatttatgc atgactcggt 2225821 cgtgagcttc ctctaaagag atatcaagag agttggctaa acaaaccaat acaaatagca 2225881 catcgcctat ttcctcttcc atgcttttat catcttcagt cgcttttttt ggtttttctc 2225941 cataacggtg attcacttct ctggcaagct cgcccagttc ttcagtcagc ctcgccatca 2226001 tggccagcgg gctaaaatat ccttctttaa attggcctat gtaacggtct acttcagcct 2226061 gtatgtcttt cattgtttta tcactcactg aacgaaacct cctatcatcc tcttacatgt 2226121 tagctaattc agatacgttt gacaaatgtt taagcacgtt tgctgttttc tttttcatcc 2226181 actataatat aaacgctatc taatggaagg aaaaggggtt ttgtgtgatg cttggagaaa 2226241 ttagattaaa aaacatattt tttattttaa tcggagcggc aattttttca tttggcttgg 2226301 ttcatttcaa tatgcagaac aatctggctg agggcggttt tacaggtatt acacttttgc 2226361 tttatgccct tttccacatc agcccctcta tatcgaacct ggtgttgaac attccgattt 2226421 tttttattgg ctggcgtttg ctcggcagga caatgtttgt ttataccctt gtcggcactg 2226481 tagccttgtc tttgttcctc agcatctttc agcgatatga aatccatatg ccccttcagc 2226541 acgacttagc gctcgccgct ttatttgccg gcgtattcat cggagccgga ctgggtatta 2226601 tttttaagtt cggcggtacg acaggcggtg ttgatatcat cgcacgttta gtgaataagt 2226661 attttgggat tccgatgggc agaacgatgt ttgctttcga tgcctgcgtc atcattttgt 2226721 ctttgcttac ttatctctcc tataaagaag cgatgtatac gctggtagct gtatttgtag 2226781 cggcaagatt aatcgatttt attcaggaag gcggatacgc tgctaaaggc gctacgatca 2226841 tctcttcgaa aaacgacctg attcagaaaa agattcttga agaaatggaa cggggcgtca 2226901 ccattttgaa aggacaaggt tcctacacaa aagaggatat agatgtactt tattgtgtgg 2226961 tgccgaaaaa tgaattggtg atgctgaaaa gcgtgattaa ctccattgat ccccatgcct 2227021 ttgtagcggt aagcgatgtt cacgatgtgc tcggagaagg atttacgctt gatgaaaata 2227081 aaaatccgct tccgcgctga catgtaatag aaaaaaggcg gctgaccgcc gcccctcatc 2227141 cttatttagg gtagtccctt tttttcagct tgtttttttc cgccttgtac tttctgtaac 2227201 cgacataggt aagagcagta atgatgatac tgccggttgt aatgatcacc cagagtaaag 2227261 acggatcggc atcatcctcc tccaccctgt caaacacatt tttcaggtca tgctgaagaa 2227321 gggaaagccg ttcaagcttc gtgctctctg tcatttgctg aaattcctct tgctcaataa 2227381 catctatatg ttttccgact gtttcaagct gatcctctga tacatcgatt gtaagactgg 2227441 ggtaaatcaa gtcatataaa ctgataaatt cattccattt ttcatgaaag cttgtgcttc 2227501 cattcttttg gacatctcgc ttcagttcag taaaagcttc cataatcggt ttttccagtg 2227561 agccccaaag cgggtcagac cgattgtcaa ccgcatccat cagcattctg aactgcgcgg 2227621 ctgctctgag tttttgtgtg tctgatgtat cagcttgctt taaactccga accatatcat 2227681 tatagcccaa tgtgatttga cgaatttggg ctcccgttag catggggtct tgctgttttt 2227741 tctcagcgga ttttaatgtt ttttcaaaat actccaagac ttgaagcgcc tcttcatatt 2227801 tcgcctgtcg ggtcatttga aagactgtat cggataaatc attcaattcc tcgaggcttc 2227861 cccgctctgc agccttggca tttccattat aaaaaataag tgcaatcaac aaacagatcg 2227921 tcagctttcg tttcatgcag gtccctccca ctctctctcc ttacagaata tgaagaaagg 2227981 gacaaggata gaccaacatt gtctttacat cagctcaagc ttcgtttgct tttttgagac 2228041 cacaagaaag taagcaagcg cgattgaaaa gatacttagc caaaatgttc cgtatcctat 2228101 ttcagtcata taatcagaaa gcatagagta ttgcggcatc atatcaaaca agtagtcaat 2228161 gacatcgtta tgcagtgtcc agactgcagc aattgcaaga tgccaaaatg aaaaacgaaa 2228221 atacggactg tataatacgc cttgaactgc cattgcaaaa tgcgaagcaa ttagcatgta 2228281 gccctcccac ggcaagtcac cagttactgc aagcacaaga aaattcatag ccaccgccca 2228341 taggccatac tttacgaggg taactagcgc aagcgcctct aaaagcggag cattccgttt 2228401 catgagaaag gcaagcagca caaacagaaa gaaaaacgtt gctgtcggac tgtccggaac 2228461 aaaaatcagg aaacgggccg gtgtctccaa aagctgcggc aagtaccaat agtagccgta 2228521 aaccgttccc agaaaattaa tggctaagac aagaataagc atcggccgct gccctaatac 2228581 atattgaaac catttcacat cgaatcaact ctcagtctgt aaaaataata tgtccatata 2228641 aaaaagctga cgccgggtca gcttttgata ataaaagtat atccttccat ttgacaattc 2228701 acaatacgtt attttgcggt tgtttcagaa ataaattttg caagttcttc gagctgctta 2228761 tcatttcctt tgaacacacc cgccggcatt ttgcctttcc cttctacagc gatttttttg 2228821 atttcatccg gtttcagccc gctgtcaacc aatgaaggcc cggccgctcc tccctgaagg 2228881 ttatccccat ggcaagaaat acagccctgt tccttaaaaa ccttatatcc ttctgcattg 2228941 gtgtcaatgt cggcttcttt tgtaattttc ccctgttctt ctgccttggc ccagtcatga 2229001 gtagcaactg actgccacgt caaaaataca gcagcggaaa tggccagaag catcataccg 2229061 acagcgaccg gacgcttcca cggccttctt tctgtccctc tgtctaggaa tggagccaaa 2229121 agcagggccc caaaagcgag acctggcata atcatggcgc cgaccactgt aaagcttccg 2229181 gcggcgtatt catacttcaa cagctggtat aagaaaagaa aataccaatc cggcagcgga 2229241 atataaccag tatcagtcgg gtccgccatc cgctctaaag gcggctgatg cacaatcgtc 2229301 aaaacgagaa aaccgatgag aaagacagct ccaaccatcc attcctttaa caagaaattt 2229361 ggccagaaag cctctgtttt acccggatac tccgaataat ccttcggtat attcggcttt 2229421 ttttcagccg gtatccttga gtcgcctaca aatttcatcc ctttgccccg gtgcatgtca 2229481 tcccctccct tttattcgca gatcaagagt ttaaagcggt cctgaaatcc cctgcttccg 2229541 gatcataata aaatgtgcag ccatcagccc gaacaatgcg gcaggaagaa aaaatacatg 2229601 gatcgcaaaa aacctagtca gcgtttgggc gcctacaata tccggatgcc ctgcaaggag 2229661 cgttttaact tgcgttccga tcaaaggcgt ggcttcggcg atctgcagtc cgacttttgt 2229721 tgcaaacaga gccttcatat cccaaggaag caagtagcct gtaaagccaa gaccgagcat 2229781 aacaaaaaag atcagcacac cgacaatcca gttcagctcg cgcggttttt tatacgcgcc 2229841 ttggaaaaag accctcagcg tatgtaaaaa catcatcaca atgaccaggc tcgcacccca 2229901 gtggtgcatc cccctgacaa tctggccgaa tgccacttca ttttgcaaat aatataccga 2229961 ttcccaggca tttttgatat caggcacata atacatcgtt aaaaacattc cagataatac 2230021 ttggataacg gttacaaaaa acgtcagtcc cccaaagcaa tacacaaacg cagagaaatg 2230081 atgggcggga ttcacatgtt ccggtacttc gtgatcggca atatccctcc acatcggtgt 2230141 aatatcaagc cgctcgtcta cccagtcata aattttgttc agcatgtcac ccttccccct 2230201 taggctttgc ttttccaaga tacaggaagc cgtcttttac ttcttgctca taatgatcaa 2230261 gaggcgcaag cggcggcgtg ccagggacat tggtgccgtc cttttcatag agtccgtaat 2230321 ggcatggaca aaagaattta ttcgggtttt taggatcact attccagttc accgtacacc 2230381 ctaaatgctt acaaattggc gaaagtgcta caatttcatc cccgtttttg aagacccagg 2230441 ctgatcttga ctcttctgac tcataccagg catcgacttg attaatttta aaatcaaagc 2230501 gctgcggctc ttttgtcaac tcatcaacgc tgacaacctg aaccatatcc tgcttccctg 2230561 tcgattttaa taccgggtcg agtgcgaagc gaaccatagg catgagcata ctagccgcca 2230621 taaaacctcc tacgcctgtg agcgtataat tcaaaaattg acgtctggat atatcatgtt 2230681 ttccgcccat ctcttctccc ccctctaagt cacccctgca aactgactaa aatagaaaat 2230741 attgcaataa ctctagacac cctcataata tatgaatctc tcagcaaggt caatatagcc 2230801 aaaatattgt ttataaggaa atgtaagtgt ttttataaag tgctccataa ctgtaacaaa 2230861 acgttcaaaa tttcagcagt gcgttcatcc aatatttttc tttttaaaga gtcatttaaa 2230921 tgctctaatg gaacagacga tgtaacaatc attttgccta acgcatcctc agctctccaa 2230981 ctttcgtcag atgtgagcag gacaacatgc ggaaattccg ttatcagctc ttcccgcaaa 2231041 tccttaagcc cttgaacggt tatttcattt ctatcaacat atgtataagg cggaagtaaa 2231101 tatacccgtc cctttaactg cctttcaagt tcttctgaga gaagctgcgt aaactcgcct 2231161 ttctccgccg ccattttaaa atggttatta acccttatgt taattaatgg tatgacagcg 2231221 gtatcaatgt aatccttagc ttgtaaatag tccttggcat cagtgattct ccacctcatc 2231281 gttctccccc tttacggcaa caagccttgc aattcactgc aaggctggtc atattatgtg 2231341 agctgattta attggcgcga taattgttca aatgcctctt tatcatgacg atctaacgcg 2231401 tcgtcaatgt cttttaataa tttttctctt tggaatgtgg aaatagcgtg ctctaaaatc 2231461 tgttccgcca atccctgatc ttttttattc tcaaaaaggt ttttcggaat atgcgggttg 2231521 gactccagca ccgccgcata ttcaggtgag ctgtaagccg aacggaaatt aagctggata 2231581 aacaaatcct gctgtttatt taatctaata tcatgaaaag atttttccgc gtcggtagtc 2231641 atgacattct ctttatagaa ccggaacgga acttcttcaa cacaatgtgt tgacattata 2231701 atgcctctcg ggcaaaattc agcctgctcc acaaaatgaa ccttctccat gagagaatca 2231761 tggctcatta agtagttcaa gatccaaacg cactctcggc gctttaactg ataatggttt 2231821 aaaaaccaac ggataaaatc ttttttctca ttgacagaaa caggggtctg catgtaattc 2231881 cctcctctat cgttcgtata atctatatac ttatatgttc cacatgaatg gttaatattc 2231941 ctgcttatct agaaaattca tcctcgattc gcaaaatcgt ttcttcaagc tcttcattgg 2232001 ctccgtccat ttcaagaacc tttttcaaaa gcggcagcgc ttctttttga agaccttctt 2232061 ctaataggaa gcttgcgtat tcatataaga aatctctatc ctcccggtaa tgaagatagg 2232121 cagcctcaaa ggattgtttt gcttcctcgt attgctctaa ttcagtatat gcgcttgcaa 2232181 gataccaatt gtatttagga tcttcttcac cgtagcttcg aacctcttga ataagatcaa 2232241 tgatctgatc ataatcctct tctttgtgat acacggcaag aagtgtatga agcgcctcga 2232301 caaagcccgg atcaagcgca agcgcctcct gaagcagctt cttcccctct tctgacttcc 2232361 cgattttcaa ggccattttg gcggcataaa ggaaaagttc tttgttatat tcatcatatc 2232421 tgatcccctc ttttgccgtt tttaatgcct cttcatacat tccttcagct tcatagcttt 2232481 tcgagagcgg catataaagt gaagtataag atggatcaag ctcctttaaa tcagacagct 2232541 gcttaatagc tgttttcaca agccccgcct gtaaggctgt aaaaccatag ccgaaaatcg 2232601 tattaggatc aggattctca tcgacagctt tctcatacca tggaatggca tcctcaaatt 2232661 cacctgaggc acttaacgat tctgccagtc tttgatggac attaacgccc ccgatctcac 2232721 tctgctcctc agccgttgtt ttaaaatatt gaaccgcttt tgcataggct ccctgagcaa 2232781 agtaaagttc tcccagtgca aaatcaataa caggttcatt gtccagaatg gactttgcct 2232841 ggaaaagctt ttgttcactg acttcgaata acccctgcat ctgataaaga tccgccataa 2232901 gcagcaaact ttccggatat gatggatctg tttccggaat agtctccagc acagcgaggg 2232961 ctttttcttc ttcgtcaata tctattaaaa gttcagcgta gaaattcgtc agttctgttt 2233021 catttggata taaatcatgt agatcactaa tcagtgaaat ggctttttct acatcgcccc 2233081 actcgtaata aagctgggct gcaatggctt tatcttcatc atgcagctgt ttttcagcct 2233141 tcgagagcgt gttgaggcct ttttctgttt cacctgcttc aactaatttt atggcttctt 2233201 gaatcaatgt attcaaatcg gaccggtcct ttcttttcct atacaacatc aaccatacaa 2233261 aaaaagcttt atttgttcgg gttaatctta tcataattca gacgaatgcc cccggcaaat 2233321 aagatgcttc tgtacggaag ggaattattg agtcttatta gtttaccaaa agatcttgag 2233381 atagaaaatg aaaaaaggaa gatcgccctc tgtacagtaa agcagctctt tgacctgccg 2233441 gcttgtaagt aaagcacatc cccccttttc gtttttctat ccgttctata agacaagcta 2233501 tgttttttcg cctcgaatta tgatctgcat aaaaaatcct gaagtaaaac ttcaggattt 2233561 tttcgaaagc ttatttaaat gctcgaagaa ggttggataa gaaacgtgaa tggcatccgt 2233621 gtgctcgatt tcaatcggct cctccgttat acaggaagca ataccaagca tcattccgat 2233681 tcgatgatct ccgtggctgg acactgcagc gccgcctttc aacgtttgtt tgccataaac 2233741 cttcattcca tctgctgtcg gttcaatttc agcacccagc ttgcgaagct cagaaacaac 2233801 agtatcaata cggtttgttt ctttcacttt tagctctgcc gcgtccttaa taacggtggt 2233861 tccttccgcc tgagtcgcaa gaagcgcgat gatagggatc tcatcaatta aacgcggaat 2233921 gatatctcct ccgatttcaa ctgcctttag agatgacgtt tctataatca aatctccata 2233981 aggctctgca ccgctatcag cagatggttt gatttcaagt tttgccccca tgttttgaag 2234041 gacatcaata atacctgtcc gagtcggatt taaacctacg tttttcaata caattctgct 2234101 gtttggaacc atcgcgccag cagcaaggaa aaacgcggct gaagaaatgt ctccaggaac 2234161 aaaaatatca gcagctgtca gtttctggcc accagcaatg gaaacactcg tttgatcttc 2234221 agaaagctta acgccaaaag cagaaagcat ccgctcagtg tggtcccgag atttatgggg 2234281 ctctgttaca gttgttgtgc cctcagcctg taatccggcc agcaaaacag cagatttaat 2234341 ttgcgcgctt gcaacaggtg atacataatc aattcctttt aatgaagcgc cgctcactga 2234401 cagcggtgta aactctccgc cggctctgcc gtcgatttta gcccccattt ttttcaaagg 2234461 ctcagtcaca cgcttcattg ggcgtttcgc aatgctctca tctccggcta ccgcgctgta 2234521 aaaaggacgg cccgccaata ttccgagcat caggcgaatc gttgtacctg aatttccgac 2234581 atctaaaagg ctttctggct ctttcagggc atcgattcct tttccgtgaa tcacgacatc 2234641 gctgctgctt tgctcaatgt gaacacccat ttttctaaag caatcgatcg tgctcagaca 2234701 atctgctccc ggcagaaagt ttttaactgt tgttgtgcct gccgctagcg cgccaaacat 2234761 aacagagcgg tgagaaatgg atttatcacc gggaatatgt atttctccat gtaaggtctg 2234821 caccttatct cgtttcattt tttccacctc aatcagcata aaaagtttca tattccgccc 2234881 gggcttcaat gcattgttct gcccttttgc ggtcgtcatc agactgaaaa ctgatcctta 2234941 aaatcccgtt aatatcctct cgtgtttcga taatgcggat attcgtgata ctgatgcgct 2235001 ccgcagctaa gatcgctgtt atctcggata ttacacccgg atgatcgggt acatccacat 2235061 ataaatcata aaatgcaggt atcgctccct tctgccgaag cggcagcccg tcgcgataat 2235121 ccttggctgt tttaaaataa cgaaatagat tttccgcatc ttcttgttct acatatgtac 2235181 ggatcttgtc aatttcacga atccactcat caaaacggtc taagatttta tctttattat 2235241 gtaataaaat atcccgccac attgccgggc tgcttgatgc aatccttgta atatctctga 2235301 acccgccggc agcaaaacgc ttaacaagcg gatacaggtt ttccgaatga tgggtttggt 2235361 gaacaaggct agctgctaca atatgcggaa aatgactgat tacgcttgta acgccatcat 2235421 gctcctctgg cgacatttcc acaaaatggg cattcgtccc cttcagcagg ttttttaact 2235481 gttccacagc ttgtttgtcc gttttctggc ctggcgttaa aatataaaat gcattttcaa 2235541 acaggaactc cttcgcagcg gccactcctg atttatgtga acccgccatc ggatgccctc 2235601 cgacaaattg atagcggcta ggcagcactt gatcagcgta atcaaccact ttttgctttg 2235661 tgcttcctac atccgtaatc aaaagctcat gttcaattcc tgaatgagcc agctcttcaa 2235721 gcataaccag tgtttgttca acaggtgtcg caatgattac tgtagctgcc tctttcacac 2235781 cgctaataaa cgaatcagca cgatcgtcta tcacgcctaa ttttaatgcc gctaccgcct 2235841 gttcatcaga gatgtcgatt ccgataatcc gtttgccggg atgatttttt ttgatggcta 2235901 gggcaatcga accgcctatc aatccgagac cggcgagcaa tattgtatct ttcatttgat 2235961 tcatacgtca tcacctggtt tatagactaa agaggtgata tttgatcacc tcttataaaa 2236021 tttcagctaa aatggcaagt atttcttcat tttgctcttt tgttccgatc gtaatccgga 2236081 gtgatgtcgg gaaacctaat gcgtttcctg accggacgat atagcctttt tccagcagag 2236141 cctgaaacag ttcatcagca ggacgtttaa agtcaattaa cacaaaattt gtctgtgaag 2236201 ggtagcactt taaaccatga gttttcgcaa aatcataata ctgctgaagg cctgcattat 2236261 tttgctcgac acaggaagca ataaacgctt gatcatcaag tgctgcaatc gccgcagcct 2236321 ggcccagacg gctggtatta aacggctctc tcgccggctc aatctggcga atcaggttct 2236381 cgtcagcaat tccgtatccg actctgagcg ctgccagacc gtatgccttt gaaaatgtgc 2236441 gcaaaatcat caaattggaa tacttgctta agagcggcac ggtttccggg taatcctctg 2236501 ctgttacata ttcataatat gcttcgtcaa gaacgacaag gacacgagaa ggaacgcgct 2236561 ccagaaatgc gagtaattct ccttcagatg tataagtgcc agtcggatta ttcgggctgc 2236621 atatccaaac gacttgtgtc tgttcgtcga tggcttctaa catggcgtct aaatcatgtg 2236681 agccgtcggg acgaagtgca atttcacgta cttcagcacc ttcaataacc gcattatgtt 2236741 tatattgcgg aaaagtgggg gcagcagtaa ccgtgtttgt tttatcgttt aaaaatgccc 2236801 ggcagatgat ctgtatgatt tcatcagaac cgttgccgaa aataagtgat gtttcgctga 2236861 cattgaggtg cttactgagc cttgtccgca aagcggcgct atacccgtcc gggtaaaggg 2236921 ctagctgttg aatctcatga tgaagcgcct cttttgcagc ctctgaacag ccgtaaggat 2236981 tctcgtttga agcaagcttc acaactttat ccaagccata ttctgatttc actgcttcaa 2237041 tcggctttcc aggctgataa ggcttcagct gttttaaatg ttctttgata cgcaaatcag 2237101 tcacctcatt ttaaactgta caagccgcta aacgccattg cataatcctc aaactcctgc 2237161 agcgcctgat ttctcgtttc agcgctgatg agccggtcct ttaattcttc tatttttctg 2237221 acgagcgcac ttcccactac gacaccgtca ctaatttcat tcatctttat gacctgttca 2237281 cggtttgata taccgaaccc tacagcaacc ggaacagtgc tgagattctt cacagtacga 2237341 atgaacgggt acacggatga attgaactca ttgcggacac cggtcacacc cagagaagat 2237401 acacagtaga cgaacccctc ggcttgttca ataatggttt tcaaacggct ttcgcttgtc 2237461 ggcgcaacta aagaaatata cgtcacctca tggcttttac attcctcttg aaggctgttg 2237521 ctttcttcta atggcagatc cggaacaagc agaccgtcaa tatgattttc ccgcagtaaa 2237581 gcgaaaaagt attctttgtt caattgtaac acaggattat aatacgtaaa gaggataatc 2237641 ggaatattca ctccgttttt tttcatttct ccgcctaatt cgattgcctt tacgatattc 2237701 attccttgat caagcgcccg ctttgaagcc cgctggatca ccggaccgtc tgcaagcggg 2237761 tcagagtatg caacaccaag ctccaatgct gtggcgcctg ctttttggag tgacttcgcc 2237821 agttcaatcg aaacctcagg aactggatcg cccgccgtaa taaacgggat aaacaatttt 2237881 tctgatggtt gaagatccaa tttaaacatg ggctttcacc tcttcttcca atacattcat 2237941 taatgtgttg acatccttgt ctccccggcc tgataaacag acgagaatga gttgaccgcg 2238001 atccattcct ttggcgagtt tgaatgcttt cgctaacgca tgggcagatt cgattgccgg 2238061 caaaatcccc tctttttctg acaaaagctt taatgcatcc accgcttctt catcggttat 2238121 actgtcataa gtgacacggc cgcttttatg caaatatgca tgctccggac cgattccagg 2238181 atagtcgaga ccggctgaaa tagagtaggg ctcaataatt tgcccgaact catcctgaat 2238241 gagataagtc aatgaaccgt gaataacccc tacggttcct ttcgaaatag tggcggcatg 2238301 aagaggtgta tcaattcctt ttcctgctgc ttcagcgccg atcagttcaa catcttcatt 2238361 taaaaatgcc tgaaacatac ccatcgcatt gcttcctccg cctacacatg ccactacttt 2238421 atcaggcata gtgccttcaa tacgtttcaa ctgatccttc gcttcctctc cgatcatttt 2238481 ttgaaattca cggaccactt gcggataagg atgcgggccg acaactgatc caatcatata 2238541 aaagtgatcc tcacaatgct gaacccagta ccggatcgcc tcatttgtgg catccttcaa 2238601 tgttccgttt ccgcttgtta caggcactac ctccgctcca agaagcttca tgcggaaaac 2238661 gttcagagac tggcgggcaa catcctcttc acccataaac acagtacagg aaaagccgaa 2238721 tttggctgca actgttgcag cggcaacacc atgctggccg gcaccggttt cagcaatgat 2238781 tttcgttttg cccatttttt tagcaagcag cgcttgacct agcgcattat tgattttatg 2238841 agaacctgta tggtttaaat cttctcgttt caaatagatt ttcgcgccgc ctaagtattc 2238901 agtgactcga tcagcgtatg ttaatgcagt cgggcgtccg gaatagtcct ttaacagctt 2238961 ataatactct tcacgaaaag cgggatcatc cttgatttgt ttaaatgctg tttgtatttc 2239021 atctaacggc tgcatgagtg tttccggaac aaactttccg ccaaaatcac cgtatctgcc 2239081 tatttcattc ggatatggat acatatcggt tcatcctttc ttctaaaagc ctcatcagat 2239141 tctgatcttt ttgtccgttt ttttcaattc cgctggcaag gtcaattcct tctggctgcc 2239201 atttcaatag gcgtgtgatg ctatccggat tcacgccgcc agcgataaag cagcgtttac 2239261 caatagccgc ctgctgatat tccggcacac attcccaaga aaatgcaaca ccagttccgc 2239321 ctctagaccc ttttacagat gaatcaatca caaagccgtc aacattatct ttaaagcggg 2239381 ctatttcttg agttgtgtta tcttgatggt gaagcgcctt ccatatttca cagcctgtca 2239441 gcttgcgaag agcagcagca tccgccggtt tttcatcacc gtgaagctga atgacgtcga 2239501 gcttcaagct cttggcaata cgtgacatcg tctctattga ttcattaaca aaaacacctg 2239561 caacctgttt ttcgacacga acttggttca gccatttttt cacatcttcc ggagatactt 2239621 ttcgtttgct ttcagcaaaa ataaatccta ggtaatcagc ctgtgattcc gccgcaagct 2239681 gcaaatcctt tagtgaccga ataccgcaat attttaatgc cggtttcttc acaacctcac 2239741 tccctaaaca aagcatggat tgctttacgc tgagaagttt gtctcatcaa tgattcaccg 2239801 ataagtacag ctcgcgcccc atgttcattg acaaatgtta aatgttctaa agaaccgatt 2239861 ccgctttcgc tgacaagcaa ggattctttc ggaacgagag atgcgatttg ttctgtctgc 2239921 tttacagatg tttcaaacgt ttttaggttt cgattattta cgccgagaat gtcgggtgtg 2239981 aacactttca atatttgttc tagcgttgat gcatcatgaa cctccactaa cacgtccatc 2240041 cccttttcac ctgcttcaag atataattca tgaaggtgta agggatcaag cacctcgccg 2240101 attaacaata tggcatccgc tccgattctt cttgattcct ctacttgaag agaatcaata 2240161 aaatcttttc taagtacagg aatcgaaaca gcacgcttta cgtctgataa atagctgttt 2240221 tccccttgaa aaaacggggt gtctgttaaa acggaaatcg catctgcctt cgcagcctca 2240281 tagtcttttg caatctgcac aggtacaaaa tcctctttaa taagcccttt tgacggcgat 2240341 gctttcttca cttcggcaat caacccgata aaccgattcg ggcttgccag cgcctcctta 2240401 aatgaacgtt tctcgaaagg ctgctctacc ggcagaacca gtgttttcac ttcttctttc 2240461 ttttgtttga tgattttttc aagcatagat ctcttcctct ttctgcttta gtcgttcaag 2240521 ctgcgcggca gcgcctccgc ttgtaatcgt ctctaacgcc agctccgttc cttccttcag 2240581 tgaggcggta attcccgccg tgtaaatcgc agcacccgca ttaaaagccg taatagataa 2240641 agcggaactg ctgcttttat tttcaaaaat attctgaatg agataagcgc tctctttcgg 2240701 agactgcacc tgtaaatctt caagtctgcc atttgtgaaa ccgaaatctt cgggtgaaac 2240761 ggtatactcc cggcgctctc cgtcctttaa ttcaatcacg tcggtcggtg ctgtaattga 2240821 aagctcatct aaaccgtcac ggcttgatac aaacataacg tgcttcggct gaaacgtctc 2240881 cagtgcgctt gccatcagtc cagctttttc aacagaatag accccaatca cctgacgctt 2240941 cgcctgtaaa ggattgctga gcggcccaag cagattaaat accgttctga aacctagctc 2241001 ttttctagta cctgctacat gtttcataga cgaatggtaa agcggcgcaa aaagaaatcc 2241061 catgttgttt gtttcaatgc tgcttttgac cttttcggga gtggtttgaa tagaaacctc 2241121 tagctcctct aaaacatcag cgcttccgct tttagaagag acagagcgat tgccatgctt 2241181 agcgattttc gcaccagctg ccgaggcaac aattgccgag gccgttgaga tattaaaagt 2241241 ggaaataccg tctccccctg ttccgcatgt atcaacaata tcaggaagtc catcgactgt 2241301 aagagcgtgt gcccgcattg ccttcacaaa acccgcaagc tcttctggcg tctccccccg 2241361 atgagcaaga attgacaata tcccccccat ttcagaagga gtcatttccg ctgccatcat 2241421 catattcatc agcgtttcag cctcaccggc agtaagggtt tttccgtcaa cgcacaattg 2241481 tagaaatctg ttcatcagct ttatcctcct tgctatgaaa catgtcttct gcaatatgaa 2241541 tcgttttcag cagcgcaccg gctttattac agctttcttc gtattcggct tccggaacag 2241601 aatcagcaac aatgccagca cctgcctgta tcgatgcaac accgttcttt acactcatcg 2241661 tgcgaatcgt aatacaagag tcgatattcc cgtcaaaccc aatgtaggca atacaccctc 2241721 cgtatgtctc tctcggtgtt ggctcgagtt cttgcaaaag ctgcatggca cggattttgg 2241781 gtgcgcctgt taaagtcccc gccgggaaag cagacatcag tgcatcgaca ggatgaaccc 2241841 cttttttcaa tcggcctgta accaccgaga taatgtgcat gacatgtgaa aaggaaacaa 2241901 tttttgtgaa ctccggcaca gaaacagaac catactctgc tactctgccg atatcgtttc 2241961 gggcaagatc aacgagcatg taatgctccg ctttttcttt ttcatccttc atgagctcaa 2242021 ccttcagtct ctcatcttca gctttgtctg caccgcgttt tctcgtaccg gcaatcggat 2242081 ggatttctaa gtgcccgtct tgaacgtgta ttaaccgttc cggagagctg ccgactattt 2242141 ctctgtctag cagtttcata taatacatat acggcgaagg attgacgatc ctaagcactc 2242201 ggtataactc aaaagcatct gcttttatcg gcacctcaaa tttttgtgat aaaacaccct 2242261 ggaagatatc gcctgctttt atatagcttt tgattttttc tacatcagcc ataaaagccg 2242321 atttttcata attagaagat actgtctcaa agctgggtgt cttgtatgaa tcagcagaaa 2242381 gaaacagctc ttttatgttt ttttggtcca tcattttttc aatgagattt tgaagctcca 2242441 gatgattttg atggaataca tccatttttt cgttttttgt ttcctctcca gtgagccttg 2242501 catattggat aaagtggacg tttttggttt catgatcata cgcaattaat gtccggcaaa 2242561 caaacagcat acacttttcc atgtctgttt ctttggtatg cgaaggaaca gaaggctcaa 2242621 tcagcgggat catatcatag cttaagtacc cgacagctcc gccgacaaaa ggaatgccaa 2242681 gctcaggtgt tttgattttg tatgtggtat tcatccagtt cagcacttct tttagttcat 2242741 ttcctgtgta aagagatttg ctgtcctgat cagcggccga aaaacggccc tgctcttctt 2242801 taattgtgag aaatggattc aggccgataa acgaatatct ggaccaagtg gatgtatcgt 2242861 ccttgctttc aagaagatac gtaatctccc tgtcaagctt ctctatcatt tgaatgggtg 2242921 tcagtgtatc gactgtgaag gtctccacaa tcggtatcgt gtggtgggac aagctgtcct 2242981 ctaaaaatgc ggaaatgttt gattggaaat tcattgctct cactccttat ggcaaggaga 2243041 atgagaagat ggcatgagag gataaaatac tatataacaa ataaacccaa aagaaagact 2243101 tcttttgggt agaataaaca taatgtctca gctcaactaa actcattctc tgctacccta 2243161 ttctctaact caactcattc taattgcttt atacacactc ttgtgtattt ctaagctgtt 2243221 cttatcgtat tacaattcag tattttttgt caatgataaa tcgggcctca atacgacaac 2243281 tttttctaaa tatacatgtc tgatctgatc ctgagggaca tctgtctgga ccgtcatcat 2243341 gactcttatg cactttttca gaccgcctgt tacgtccatt tcctgcatac atgttaccgg 2243401 tacatactgc catcctgaaa gctcgcgaac agcttttgcc gggaaaacag cgtgcaaatc 2243461 aggtgtagcc gacagaagca tttgaacaac atcttccggt tttgtatgat tttcttctat 2243521 gattttctct aacagctgtt tagttttttg taaaatttct tcttcagtat cccgttcaac 2243581 tgtagttgct ccgcgaattc cgcgaatcat catgatgtct cctccaatcg ccatttgttc 2243641 agccagctct caagttcatt tctggaaaat gtatgatcag caactttccc taattcgttg 2243701 agcacaataa actgaatctt cccgccacgg gttttcttat cattcatcat acggttcaag 2243761 agaaccgaag tttccgtctc ttttctgatt tgacttggat aacccaggct ttttagccag 2243821 ctgaccaaac gttttctgtc catttcacag cctacagtct tttcgcttat atataaagca 2243881 aactgcattc cgagggctac ggcatcaccg tgagtgatct gcccatatcc atattccgcc 2243941 tcaacggcat ggccgagcgt atgcccaaag tttaagtaag ctcttatccc ctcttctttt 2244001 tcatcctgct gaacgacaga cgctttaatt gaaatgcctt taaaaatcat gtcattcagc 2244061 tgatcattag tgatatcacg cagtgagtgg atattcagca gctcctccag aaacgctctg 2244121 tcatagataa aagcgtgttt aatcacttct gccattccgg acctaagctc tttttcaggc 2244181 agagaacgca ggaaatctgt atcatagagc acggctttcg gctgataaaa cgcaccgatt 2244241 agattttttc caagcggatg gttcacggct acttttcctc cgactgcgct gtcatgcgcc 2244301 aagagcgtcg taggcatttg gatgaaatca atgccgcgca taaaagtggc agccacaaaa 2244361 ccggcaagat cccctacaac accgccaccg aatgcgatga tgcatgagga gcgatccata 2244421 tgaaaacgaa tcgcttcact ctgcaatttt gtgtacatgt ccatggattt tgcctgctct 2244481 ccactcggta ccgtcacttt tttcacaggc catttttctt gcagcaaatg gagcatttca 2244541 tcaccataca ggcggtccac ttcttcatcc gtgacaaaca taatccttgt taaaggcctg 2244601 tttaaagagg ttaatagttc gcaagccttt tttctgatac cttgtccgat aaaaacagga 2244661 tatgacgagg aagcagtttg aacatgcagt gtcttcatta aaattccctc gacagttttc 2244721 tcatattctc cacattttct ctaatgcggt caatttgatc taatccgaat tgttcaacga 2244781 ctgcgttcgc aatttcccaa gcgacagccg cttcagcgac tacacttgcc gcaggaacag 2244841 cacagctgtc tgaacgttca atgctggcag aaaacggttc tttcgtttca atatcgacac 2244901 ttttcagcgg tttatacaaa gtcggaatcg gcttcatgac tccgcggaca acaatcggca 2244961 tccctgtcgt catgccgcct tccagtccgc caagtctgtt agtagcacgg gtgtatcctt 2245021 tttcctcgtc ccaaatgatc tcgtcatgga cttcgcttcc atttcgccct gctgcctcaa 2245081 atccgatgcc gaattccaca cctttaaatg cgttaattga cagaacagcg gcagcaagct 2245141 tgctatccag cttgcggtca taatggacat agctgcccac gcctaccggc attccctcga 2245201 caatgacttc tactattccg ccgatggaat ctccgtttgc ctttgcttca tcaatggcag 2245261 ccatcatttt tttgcctgcc tcttcatcgt agcatctgac aggagactct tccgttacac 2245321 gctgcaagtc ttcaattgac gtatactctg ttttttcagc tttaacagcg ccaatttgca 2245381 acacgtggcc cgccacctta atgccaagct cagaaagaat ctttttagct acagcccctg 2245441 ccgccactct gacagttgtt tcccttgctg aagaacgctc aagcacattt ctcatatcac 2245501 gatgattata tttaattgca ccgtttaagt cagcgtgccc aggtctcggt ctggaaatct 2245561 ggcgcttcat ttccttttct tcatcttctg taatcggagc ggcgcccatg atttttgtcc 2245621 aatgcttcca atcgttattt tcaactacga gagcaattgg cgaaccgagt gtacgtgcat 2245681 ggcgcacccc gctcataatt ttggcctggt ctttttcgat ctgcatgcgg cggccgcggc 2245741 cgtgtccttt ttggcgtctg gcaagctcaa aattgatatc ttcctccgtt atgtaaagcc 2245801 cggcaggtac accctcaata atggttgtca gttgggggcc gtgtgattct ccggctgtta 2245861 aatatctcat gacttcttct cccttcatcg cattaacgct tttaagtaag actactataa 2245921 catatttttc agcaaaaagt cagtctatct tttttgataa aagaatgtat cggctgggac 2245981 taggccaaat ttctcgggat tgaagatttg ctcggtgctg ccgacaaaaa gaactccatt 2246041 cttcttcaag ctatgtgcca tttttaaata cagctcttcc ttcgcgcttt ctgtaaaata 2246101 aataaataca ttgcggcaca cgattaagtc aaagtcttgt tcataacgat ccgccagcaa 2246161 attgtgcttt ttgaatgtaa tattcttttt gatttccgtt ttcacttcat aacttctatt 2246221 tgcgttttgc gtaaaataac gatctttcac agatagcggc acttcctgta aagaccgctc 2246281 ctgataaacg ccttttttcg ctttttccaa tgctttttca tcaatatccg tcgctaaaat 2246341 ctgatagccc ggaagacctt tttgctggtc caaaagcatg gcaagcgtgt atggctcctc 2246401 ccccgttgag caggcggcac tccaaatttt taaaggccta gaggtcttga ttaacggcag 2246461 aattgcagtc tcaagaactt cccatctttt ataattacga taaaattctg aaacattgat 2246521 cgtcattctg tccaatgttt catttaagag agcttgatcc ttttccaatg ccgcagcaaa 2246581 gtccttaaag ctttggaacc cctttttctc ataaagtgac gttagccttc tcttcatttg 2246641 tgcttcttta tatagtgtta aatcgactcc ggttaattgt ttccatttcg ttgtaaatac 2246701 gctgtatgta tccatctcta ctctcccagt ctcgctgtct ttttgtccta gtatagcttg 2246761 ttttatcagg aaattgtatt gtttcaataa aaaaatcagc ttttcagctg attttagatc 2246821 gttgggaaag gcagaggtct gatgcacact gccattcaac cctttattca ctttaatgta 2246881 aacctttaca aaacagaaca aaaaccggcg gcgttatatg ttgccggctc tgttgcttat 2246941 tttcacaatg attaatagat ccagcctgcc ataagctgct gatatgatac taattcttca 2247001 ttcttaaaga aaatgttaat ctcgcgttct gcactttcga gagaatcaga gccgtggatg 2247061 atgttttttc cgacaaacat gccataatcc ccacgaatcg taccaggtaa agcttcttta 2247121 gggtttgttt tcccgatcag ctgtctcgtc acttcaatga cattttcgcc ttcccacacc 2247181 attgcgaata caggtcctga agtaataaac tcaacgagct ctccgaagaa aggcttacct 2247241 tgatgttcgg cgtagtgttt ctcagccatt tgttcagtca ctctcattaa cttggcgcca 2247301 gctaattgta agcccttacg ttcgaatcta gataaaatgt ccccaatgag ctgacgttgg 2247361 acaccgtctg gtttcaccat gataaaagtc ttttccatca tattctccac cccatcatta 2247421 tgtatgtata ggctttcaca ctgcacaccg aaatcgtaac atctttctga taattaatca 2247481 atccggggcg gagaaatttc ttaatatcta caaaaattaa aattttcttt taccgatata 2247541 ttttgcgatg gctgcaagag acgagcgtgc gcgccctcga ggaagcgtgt ttaatttctg 2247601 aaaagctttc tgcagataca tttcgcttac tgccatagat gcttcaattg catctgtttt 2247661 tttgatttct tcaatgattg gttcaagctg ttcctgcgtt gtctcactgt taatcaattt 2247721 aagctggttt tttaatgcag gatttttcag ggcatacagc actggcaatg tgacgtttcc 2247781 ttgaagcaaa tctcctccta cgggtttacc cagctcttcc tcagttgaag taaaatcaag 2247841 aatatcatca ataatctgat aagacatgcc gacgtaatac ccaaaccagt acaatgcctt 2247901 atgaatcttc tcatcagctc cagacgcaat ggcaccaagc tggcagctga ccgcgatcaa 2247961 gagagctgtt tttcttttga tacggcggag atacgttctg agattttgtt ccatgttgta 2248021 tttgtctttg atctgctcaa tttcccctag acaaacttca acgatcgtct gtgacaaaat 2248081 cctatgggct ttcggttcgt taattctcgt catcatttca agagatcccg caagcatata 2248141 atcgcctgtg tacatcgcaa tacgattgtc ccactttgct ttgattgtcg gttttcctcg 2248201 gcgaagctct gcatcatcaa tgacatcatc atgaaccaaa gatgccatgt gaatcatttc 2248261 cagagtgacg gcgacatatt taatcttatt aatatcataa tcgccaaaca tgccagaaag 2248321 cagcacgaaa acaggccgaa tacgtttccc tccggcctgc agcaggtgaa gacctgcctc 2248381 gcttaaaagc gggtaatcgg aacgtacggt ttgttcaagt tctctttcga ttacatcaat 2248441 atcgtcattt aaaaaagagt aggccatttt aaatttcata tcattcaccc aaacatctgt 2248501 gttttcattt ccatccgata tgcgtggcag cgactccgcc agtaaacgaa tgatatttaa 2248561 catttttcag gcccgcctct tcaaacaggc ctgccagttc cttcattcca gggaaatctc 2248621 tggctgattc ttgaagccaa gaatattctt tatagctctt cgcaaacagt ttcccgaaaa 2248681 acggcataat atacttaaag tacataaagt aagcctgtct gaatccgaac atttccggct 2248741 gggacgtttc cagacatacc acctgcccgc ccggcttcac tacacgtctc atctctttca 2248801 gtacagtcaa gtaatcaggg acattgcgga gtccgaagcc aatggtgaca taatcaaatg 2248861 tatcatcatc aaaaggaagc tccatcgcat ttccgtgcag cagttcaatt tggctgaatc 2248921 cgccgtcttt tactttctgc tcgccgacac tcagcatatt ttcactgaaa tccaagccct 2248981 tgatctcgcc gcttttgcct gccgcttttg caagagcgat cgtccagtca gccgttccgc 2249041 agcagacatc aagtgctttt gcgccttcct ttacattcat gatgcgcatc gttttgtcgc 2249101 gccatttttt atgctgctga aaactgatga cagagttcat ttggtcataa tttttatata 2249161 ttttttcaaa tactccgtgt acgcgctgtt cttttgagtc ctgcataatg gtttaccctt 2249221 cttccacttt ctgatgatag gtttgatctt ggctgattgt cttcagacgg tttattaaaa 2249281 tgttctgaat aggtgaattt agaggcagaa gtgactcaat gctgtttttc gcttttttaa 2249341 aacaatcttc taatatctct tcttttgttt ttcccagctg tataaaactg ccgatcacat 2249401 ccagaaatgc atcatttccg ttcataagcc gcttaaatac aaaaaaatca ctcgacagct 2249461 ttttccagcg cgggaggttg aagtgttccg ccacacgatg gaataaagct gattcaacga 2249521 tgccgacact ttcgaaaaaa tcgttttcgt ccttgaaaga acggtcatac agacgaattt 2249581 tatgttcgtt gatttcttta atggctgtag caagcgtccg aatcatgtag atatccttca 2249641 tttcagatag taaagagtag tacagcccgc tgaaataatc gcccgcgaga acagtcaatt 2249701 ggcggttttt gttttcgtct cgttttatga ctctagctgt cgtcacttca tcatgggtat 2249761 caagggcgct ttgtacaagc atcgctgtta caatataatt ttctctgtcg ttgtttttta 2249821 tgtcggcttc ttcaaataaa gcatgaaaaa gaagaagctt atcctcatca attttcggcg 2249881 cagaaatatg cttcgctaaa taaggatgag acagcttttg ttttaatttc gtgttcagat 2249941 tggctaaagt tccgtagatg tcttgcaaaa atatcaccct tgtccccaaa ttcacattta 2250001 tttcttaatc tatgtatgag ttttatcttt tcattcgctt acgcaggtat cattatagca 2250061 taaaaaaaag aaattggctg tatcctcccg ctgtttgcga gcatttgctt ttaacagcgg 2250121 ggacagccag cttatttttt ttcgcttttc atttctccgt acgcggtttg aatcagtgcc 2250181 tctcctctga ctttaatggc agaagtatgc tctgtaaact gagcgatgat cacttctccc 2250241 ttgtcgagtt tttcggaatg gtgaaacttt gtgtctgttc ctcttgtcag gccgatcaca 2250301 ttcactccgt cctcaacggc tttaatgacg acaaaatcac ttgaatgctt ttggttcatt 2250361 tatagcaccc tctatcttta ttagtcctgg cgtttaatat gttccaatac ttctgcacgg 2250421 gcagcggcat catctttaaa aacgcctctg actgctgaag tcacagtttt cgcacccggt 2250481 tttcttacac cgcgcatcgt catgcacatg tgttccgctt caaccactac cattacgcca 2250541 tgcggatcaa gcgtttctac gatgctttct gcaattgtag aagtgatgcg ttcctgaagc 2250601 tgcgggcgct ttgcaacggc ttcaacggca cgtgccagtt tgctgagtcc tgtgaccttt 2250661 ccgcctcgcg ggatatatgc aacatgtgct tttccataaa agggaacaag gtgatgctca 2250721 cacatagaat gaaacgctat atcttttaca agaacaagct cctcatggtt ttcaccgaag 2250781 atagtctgga aatgttcttt tggatcttca ttcaagccgg agaatacttc ggcatacatc 2250841 tttgcgactc ttttcggagt atcaagaagc ccttctctat tcgggtcttc tccgatcgct 2250901 tctaaaattt gacgaacagc ttgttcgatt tgctctttat taacttcttt catgttctat 2250961 gtcctccacc aatgaataca tttaatttcg attctagcac atatgccccg ctaaaagcaa 2251021 agtgaatgcc ctgtcaggaa gcccatgctc ttgaaatatg aaaagcccct tagaaagggg 2251081 cttttctgtg aagaaataaa gtgtatgtaa gctagatgca tacacgatct atattcacaa 2251141 ttattttccg gcaactgcgt ctttaagcgc tttacctggt ttgaaagcag gtactttgct 2251201 tgctggaatt tcgatttctt cacctgtttg aggattgcgt cctttacgtg cagaacgttc 2251261 acgcacctcg aagttaccaa aaccgatcag ttggatttta tcaccgtttt taagtgcatc 2251321 taagatcgta tcaaaaacag agtcaactgc ttttgtagcg tcttttttag acaattcgct 2251381 tgcttctgca accgcattga taagttctgt tttgttcatg cctttcacct cctcccaaaa 2251441 ggatacattc agttcgttta ttatcatttc ttcacagttc agtctgattc taaacctgtc 2251501 tcagaaaaaa atgagagcaa gtaagagaaa gacaattaaa cggcttttta agaaaaactg 2251561 cactctgagg aatgtttgtc caacaaagtg aagaatttct gtatgtagag taacacatat 2251621 aaaaagccat atcaagcatt ttaaagcgtc aatcccttgc tcgtcaagga tttaaggtga 2251681 tttaccgaac gaatattcct ttttttcctt ttttcatcct attccttgat ccttttccat 2251741 tattaagagc aaagaaaaaa gacctcccat tctataaaga ggtctaccgg tattacagga 2251801 tgatggcgat taagccgcca gagccttcgt ttatgattct ttctaatgtt tcttttaatt 2251861 tataccgtgc gttttcaggc atcaatgaca gctttgcctg aatcccttct ctcacaattg 2251921 agctcagcga ccttccgaag atatcggaat tccagatgga gagcggatca tcctcaaagt 2251981 cctgcattaa atagcgtaca agctcttcac tttgtttttc cgttccgata atcggggcga 2252041 attcgctttc gacatctact ttgatcatat ggatcgacgg agcgacagct ttcagcctca 2252101 caccgaatcg cgagccctgc cttataattt ccggctcatc gagactcata tcagctaaag 2252161 caggcgctgc aatgccgtat cccgtctgtt tgaccatttt taaggcatca gacacttgat 2252221 catattctgt tttcgcatgg gcgaagtctt gcatgagctc aagcagatgg tctcttcctc 2252281 tgatttcgac gcccacaact tcttttagga tttgatcata tagatgatca ggcgcgtaca 2252341 aatcaatttc tgccacccct tggcccagct caattccggc taatccggca ctttcaatga 2252401 attcaaactc gctgaattgg ccgacaaccc tgtctacgtc ccggagccgt ttaatatcct 2252461 taaccgtttc cttcacggac tcctgatagc tttcacgcaa ccaatggttt tctttcagca 2252521 ccattaccca gcttgggaga ttgacattca cttctagcac cggaaactcg tagagggcct 2252581 ctctgagcac actcagcaca tctgattccc gcatgctctc tacactcatt gccaataccg 2252641 ggatatcata tttttcgctt aaatcctggc gcatggcttc cgtttccggg tgatacggcc 2252701 tgactgagtt gatgaccata ataaaaggtt tgccaacctc tttcagctct tcaatgactc 2252761 tttcttcagc ctctatatag tcacttctgg cgatatctcc aatggtgccg tctgtcgtaa 2252821 tgacaactcc gatggtcgag tgttcttgaa tgacttttcg tgtgccgatt tcagcagcct 2252881 catgaaatgg gatcggttct tcgtaccaag gcgtattgat catccgcggc ccgttttcat 2252941 cttcatatcc tttagcgccg ggcactgtgt aacctacaca atctactaat cttatattca 2253001 catcgagtcc gtctgacaca tgaacagaca tcgcctgatt cggaacaaat ttaggctctg 2253061 tagtcataat ggttttgccg gctgcgctct gcggcagttc atcctgcgct cgggcccggt 2253121 ctgcttcgtt actgatattc gggagcacca caagctccat aaatttttta atgaacgtgg 2253181 attttcctgt acggacagca cctacgactc ctaagtatat atcgcctcct gttcgttcag 2253241 cgatatcctt gaaaatatcg accttttcca agtgatcccc tcccggactt cctatccttt 2253301 tcaattttat taagctcttt caatcaaaca caggacacta tatgtgtatg acgttgtcct 2253361 atttgaatat gacatcttta gaaaatttct catcctcaat ctattaatat aaaaaaacct 2253421 ttctccctat ttgtatgcaa gggagaaagg ttcattcctt tttcatatca ttttctaaaa 2253481 aaacaggttc ctgtttgtca tttaccgtat attttacaga aaacgcgggg acaaaggggg 2253541 tttcatgcca aatcatatcc tggatttcag tcccgggttt aaacgttttt ttgctttttt 2253601 tgaggcaaga agccagctca gtccggtaat cggcatatat ttctccgtct ccgtcaatca 2253661 taagcggcaa ggaattccct gagattgggc ttgtcactgt aagagagctg ccatccccaa 2253721 gcttcttctc atcgagtgta aataaatcac gagatagcac atccttgtaa ggcggatatt 2253781 gatgctcctg acgatacatt tggatgcgca atttcacatc gcgaattttt tctgccatct 2253841 ttagatcaat taatttaaca gtcggatcgt tctctacgtc aacaagcacg tattgatagt 2253901 ctcccccgct ttcaaatgcc gtacttggag gttcagctat gtatcttggc gctaaccggt 2253961 taaagtctat cggatatttt tgatatagcg gtgtcgacat atctttggtt tgaataggaa 2254021 gcagccctcc atttgccttt tgaaattcat caacagcaga ttgaacctgc tttagctggt 2254081 cttgataagg aatggcatgc acactgcttt tccgttcatt tggatataaa catccggata 2254141 aaaacacgac tgccgcaaaa atgattgcgc acttcagttt acccatacag cacttccttt 2254201 tacagcttta ttcattgaca gggccgctaa aaaccacgac aaacacaata attccagata 2254261 tgagcataca catgtatgcg aatgatgaaa tcgcaatctt caaaaaacgg ttttggcact 2254321 taaagcggct taaatagatg gaagctacag ccagaaacat cagacccatg gaccctagag 2254381 caaaccacat tttcatcaat gccagattca atgacgtgcg cctccccgat atgtaagata 2254441 taagcgttat attatatttt aatatacagc gccggaaaag atcaaccaga ttttccatcc 2254501 attgatagaa caaaaaaact gaagcaaaga gggggacctt cgcttcagtc aacttgacta 2254561 tattcacctg cacgtttaag aaacactctc ttggacttcg atgctatagt atgcgacttg 2254621 gcatacagat gcatcctcta ttgcctaaat cggcaaaatg tttcaggaga tcccaagact 2254681 tgggtgttct tctgtttttc gggctttcgt tcaattaaga tatgcgattc accatttgat 2254741 tgacactttt acttcacttg attttcaaac gtatttacca aatcctccat ctcgtgggtt 2254801 ttccctctcg ccattaaaga ttcaacagcg gtttccactt tttgtccgtt gaataggacc 2254861 tgatggagag cttctgtaat cggcatttta acatcatatt tcttcgaaag ctgataagcc 2254921 gctttcgtcg tgcggacgcc ttcgactacc attcccatct cttcaagaac atcttcaagc 2254981 ttgtaccctt ttccgagcaa attgcccgca cgccagtttc tggaatgaac acttgtgcac 2255041 gtcacaatca gatcgcctac tcctgtcaat ccagagaacg tcaagggatt tccgcccatt 2255101 ttcgttccga gtctcgcgat ttcggcaagt ccgcgtgtaa tcaaagcagc tttggcattg 2255161 tcaccgtacc ctaaaccatc tgtaattcct gcagcaaggg caataatatt ttttaaagcc 2255221 cctccgattt caactccgat aatgtcagga tttgtgtaca cccgaaaatt gtgattaata 2255281 aatagatcct gcacctcttc tgctgccctc atgctctttg aagatgcagt aacagttgtg 2255341 gggtgccgca gccctacttc ttccgcatga ctcgggccgg aaaggacaac gatatctttt 2255401 ctgacatcac tcgggagctc aatttccata atttcagaaa tgcgcagaag tgaatctggc 2255461 tcaataccct tgctgacatg aacaaagact gcctttttcg ttataaaagg gacagcctgt 2255521 ctcagcactt cccgaattgc ttttgtcggg accgcaacga taatgacatc tgcgtctgaa 2255581 acagcctctt tcatatctgt tgttccttta atggatgtag acagcttaac attcggcaaa 2255641 taatctttgt tttcatgcaa ctcattaatt tgatgaatta aatctgcacg gtgagcccac 2255701 acacacactt catttccatt atcagttaga actaaagcca gtgctgttcc ccaactcccc 2255761 gctccaagca ttgtgacttt tttcatgttt gattcacacc tttttatttt ctagctcttg 2255821 caaatatttt gattggtgtc ccctcaaaac cgaacgcgtc tctgattcgg ttttctaaaa 2255881 accgttcgta tgaaaaatgc atcagttccg gatcgtttac aaacacaacg aagcttggcg 2255941 gctttaccga cacttgagtc gcatagtaaa ttttcaaacg agaaccgtta tgagtcggtg 2256001 tcggattcat tgccacagcg tccatgatga catcatttaa gacgtttgtt tgaactcgaa 2256061 gtgaatgatt ttcactagct ttgataatcg caggcatcag agtatggatc cgttttttcg 2256121 ttaaggcaga cataaatagg attggcgcat aatccagaaa ttgaaaatga tcgcgaatat 2256181 tttcttcaaa ttctttcatc gtgctctcat ctttgtcaac agcatcccat ttgtttacga 2256241 cgatgacgac ggccttgccc gcttcgtgtg cataaccggc gatacgcttg tcctgttcaa 2256301 taatgccttc ttcgccatcc agcacaaccg ccacgacttc tgagcggtca atcgctttta 2256361 gcgcccgcag tacactatac ttctcagtcg tttcatagac tttccctttt tttcgcatac 2256421 ctgcagtatc gacaatgaca aactcctgct ggttgtaagt aaatgacgta tcaacagcat 2256481 ctcttgtcgt tccagccacg ttgctgacaa taacgcgttc ttcgccgagc atcgcattca 2256541 caagtgaaga ctttccgaca tttggacgtc cgatcagaca gaattgaata acttcttcat 2256601 tgtatttcgt ttcaggaatg tttttaaaat gctctgcaac ggcatccagt aaatcaccca 2256661 gtccgagtcc gtgtgttccc gaaattggat acggctcgcc aaagcctagc gaataaaaat 2256721 cataaatatt cgctctcatt tctgtgttat ccagtttatt aaccgctaaa acaacaggct 2256781 tttttgtgcg gtacaaaatt ttcgccactt cttcatcagc agctgtcacg ccttcacggc 2256841 cgttcaccat aaaaataatc acgtccgctt catccatggc gatttcagct tgctggcgaa 2256901 tctgcgctaa aaacggctca tcaccgatat caataccgcc cgtatcaatc aaattaaaat 2256961 cataattcag ccattcagcc gagctgtata tccgatccct tgtcacgcca ggggtatctt 2257021 ctactattga aattctttct cccgcaatcc ggttaaagat tgtggatttt cctacatttg 2257081 gtctcccgac aatggctacg acaggtttac ccatagtacc cttcctttca atccagccgc 2257141 tttcattttt acataaattt tcaaccggtt attaaaatca tttcattcac ttttatgaaa 2257201 agaaaccctt cagaggaagg gcttaactca tttattatat cagtttttac tgggatcaca 2257261 actattctta aaaatgtttc acgatcaaat acacgtcatc tccgattctg tgagctattc 2257321 catcaaggat cgcctcaaga tttttagcga aaagctccat ctccttttgg tcattgcaaa 2257381 aaaagacagg tgctccccct gcaacccgat ttcgatttgt cgtgattaca gacaaaatca 2257441 ctttcgtaag agattcactc atcctatcac cttatcctga ttcttgataa attcagtcgg 2257501 cattctaatc gcattttcca gggttggaac attgctaata atttgaacag ccgtttcggg 2257561 atggtgaatt tgcgggagaa caaatactgc cactctccca tcatttaaat cccgttttgc 2257621 aattggtgtc aaagatggct ctcctgaatc ccgataaacc ccgagcacat tggaaacatc 2257681 aaataaaatg gcctgacgct gccctaaatt tgctatcgtc gctgctgaat taaagttttt 2257741 cggcgtcaaa ataaagccca tgccatgctt taaaatcagt tcctgtttct ctggaagccc 2257801 gatattcatc atataaatat tatcaacaaa cagtcccgga ccgtcaaagc gcggctttat 2257861 gtactcgata tctacaatat ccttcaacac actgcccgac ataaacttca tggccagtaa 2257921 aaaacaaacg acagccgcta tgactgcagc ccagatggat aaaaacacat acgcagaggt 2257981 tgtcaaaagc gctgtaaaga tcacaatata atttctgctt tcaaacgcaa tggcaatccc 2258041 ctcaatatat gtgcttcccc ttgagacaag ttcatacgaa tccatttgcg tcaatgtgtt 2258101 ccgctccatg tttcggacat ctctaaattg cgtcgctgcc aatgttaaaa atgtgatggc 2258161 cgtaaattcc tcctgcaaaa gcgccggcat aataattgca cctaaaccag ccgctatcaa 2258221 ccccagtgcg atgtgaatca ctttcccatg aacataggtc ggatactggc ggtaatccgt 2258281 tttcagcata taaagccttg tcgcaattcc ggcaatgacc ccagcaataa tcggatagat 2258341 gtaatcactc atgacatttt ggtagctcct ttgtttgatc ttttgctttt ctgaccaatc 2258401 tggcttgcga ggtgttcgta tttagatatg ccaaacagca atatcatccc cgcagaacac 2258461 gcattcagcc attgaaagcc gccgacagcc atagccccgg ccaacttctg gatcacaaat 2258521 gaatacacca gttcgccttg gcacatccct aggacaaata agacaagctg cttctcaaaa 2258581 ttcctttcaa cagaagctgt taaaagcact attaatataa cagcagccca ctcaggtttt 2258641 atgatgaacc aaaccgggtc atataatgca aaaagataaa caaacgcata cgcggcaaca 2258701 agcgtcagat agaccatgat gtaacgaaaa cgatacattc ccaaataccc ggcatagaca 2258761 catccgcaaa cgaaaaacat caaatatgca gcattcaggg aaaaatataa agcgatgtca 2258821 tgtatgctta gaataatatt agttaaaata aagacagaga cggcaattcg tcttttcgtc 2258881 ttttcaaaaa taaatgttgt cagaacccac agaaaccaca ttgaccaata gtaataaaat 2258941 tgttccattt tacttcctcc atattcccag tatggagttc aagcacattt tttaaacaat 2259001 cgatctcaca ttaaggagta tgatcatggg aaaagacaga caagagaaaa aactcaaagc 2259061 ttcaggcaga gtcgaatcag atcgcgacca gtccattcac tatgacggag cgacaagcct 2259121 tgaacaaaac ggaagattca aaaagcgaaa atcataatac aaaaagccca aaccacatat 2259181 ggttttgggc ttttatcatt tatcgcacac tatagcttga tgtattgacc cctctctctg 2259241 tgagccaatg atgggtttca cctttgatca caaggggcgc cttttgtaaa tcggcaattg 2259301 ttctggcacc cagcacggtc ataatcaact ttaattcctc aaggatcagc tgaatctcct 2259361 caagcagtcc ttcctcaccg ctgtcagtca gcgcttttaa aaaatgccct gccattccgg 2259421 tgcaagaggc ccccagcgca attgcctttg ccacgtcaag cgcatcttgc agaccgccag 2259481 aggcgatcat ggtgcttgca ggaaactcag agcggatttc cgccaaactt gcagctgtcg 2259541 aaatgcccca cgaattaaaa aaggagattt gccgctgtct tcggagattt tcgattttcg 2259601 agaaatttgt tcccccgtaa ccgccaatgt caacagctgc agcaccagct tcatacagct 2259661 ttcctgctga tgctttgctc ataccgaagc cgacttcttt cacaatgacc ggtacactga 2259721 cccggctgca aatttgttca atgcgtttca atgcgccgct aaagcttctg tccccttcag 2259781 gcatcacaat ttcctgaatc acattgaggt ggatctgcag tgcgtttgct ccaatcatct 2259841 caacggcttc ctttgcctga gcagccgttg cctcgcttcc caggttggca aaaatcagcc 2259901 cgtttgggtt ttcctttcga acaatttcat aggaaagacg ctctgatgga tcttttaatg 2259961 ctgacatttg cgatcccaca gcaaggggaa ttccagcctg agaagccgct cgcgcaagcg 2260021 atttattaat ctcatatgta agttttccgc cgccgccagt cattgcattg ataaaaatcg 2260081 gcgaactgct tgaaagttcg ccgatttttg tggaaatatc tacttgttct aatgcaagat 2260141 cgggcagact gacgtgaaca aacgtaatat catcaagacc tgtttcccgc ttctggccga 2260201 tggacaaggc atgattgatg tgttgtcttt ttcgttctgc tcgagtcacg tttatcacca 2260261 attattttag tttattcagc ttatctccga tcagatctcc aagctggaag ccagtgcttg 2260321 tttcttcctt cgcttgatat tgacggtaat cttcctggtc agctttaggc gtttcttcaa 2260381 gttcacgcat gcttaatgaa atgcgctcct cattttcatt cacatcaaga accttcactt 2260441 ttacagtctg tccttcttca aggacttcat gcggcgtgcc gatgtgttta ttggaaattt 2260501 gagaaatatg aacgagacct tcaacacctg gaaggatttc aacaaaggca ccgaagctta 2260561 caagacgctg tacagttcct tcaagcacat cgccaggctt cactttttcg ccgatttggt 2260621 tccaaggtcc aggcagtgta tctttgatcg ataaagaaat acgttcatta tcacggtcaa 2260681 ccgataacac tttcactttt acttcttgtc cctcttcaac aacgtcagac ggcttctcta 2260741 catgagagtg ggaaagctgt gaaatgtgta caagtccgtc gatgccgcca atatcaacaa 2260801 acgcgccaaa gtcagtcagg cgctgtactt tgccatcaag tacacttcca acttcaagag 2260861 actgaagaag ttcttgtttt ttattcgctt gttcactttc aacaacagca cggtgtgaaa 2260921 ggatcacgcg gtttttatca cggtcaagct ctacaacgag cagtgacagt gtttttcctt 2260981 tatagtcagt gaagtcttca acgaaatgtg cttcaacaag tgatgccgga ataaaaccgc 2261041 gaacgccgat atcaacgaca aggccgcctt tcacgacatc tttcacttca gcttcaaaca 2261101 cttcttttgt ttcaaatttt ttctcaaggt cttcccaagc gcggtctgca tcaacagcac 2261161 gtttagataa aatcaaagca tcgtcttcca cttttgttac tttcaggtca agctcgtcgt 2261221 ctactttaac aacatccgat gctttctcta catgaagact tgataattca ctgattggaa 2261281 taataccgga ttgtttgaca ttgataattt ctacatctac atgtttgtct tctacctttg 2261341 tcacaatccc tttaactaca tctccaacct ctggcacttg aacatcaatt tgattcattt 2261401 cctctgtcat ttgaataacc tccttggtcc aaacctacac agcttaatta aaacggtttg 2261461 aaagctgaac atataacatg cccgctttta gccgaatatg tattaaagaa tcatccaaaa 2261521 aagttttttg aatgatcaat aaaaagtttt attagtatta acttctaata aaaggacagg 2261581 tttgtcaagc aataacattc tatcttcgtt gaaaaattca aaaaaagtgg catttgccat 2261641 cctcagcggg acttttgctc cacagcctcg aggattttat cagctacctc ttgaatggaa 2261701 agcgatgtcg tgtcgatttc aagagcgtct tctgctttac gcagcggaga tacttcgcgc 2261761 tctgaatcaa gcttgtctct tcttgcaatt tcctcaatta atgtttcgta gttgacatca 2261821 aagccttttt tcacattttc ttcataacgg cgtttcgctc tctcttccac agatgccaaa 2261881 agaaagattt ttacttctgc atttggcagc acatgcgtcc cgatgtcacg accatccatg 2261941 acgacgccgc ctttttcccc aagctgctgc tggcgtttca ccatttcttc tctgacactt 2262001 ctgtgcttgg ccgcaattga aacttggttg ctgatttcat ctgttctgat cgcctcagtt 2262061 acatcggtgc cgtttacaaa cactttttgt ccatcttttg ttgtaatcag ctcaatgtct 2262121 gtccgcttta gcagctcagc cagtttttct tcatctgtca gatcaacgtt ttcctgtaaa 2262181 gccgcgtacg taatcgcccg atacatcgct cctgtatcaa tatatatgta cgattttttc 2262241 tcagccacaa ttttggcaac ggtgcttttc cccgcagctg ccgggccgtc gattgcaatc 2262301 gataatttct tttccataat tcctctcctt gctcttttct cctctaagga ttgtatcacg 2262361 aactttatga aaaagggtga aaaattgatg aataattaat gtttgaaggt ttcaatccta 2262421 ttgttttcct ccattttatc caccccttca tattgaatca cttttgatac gtatggttca 2262481 atatgctgat agtgaaaaag aaattggaca ccaagtaaaa tgatggcctg aatgaacaat 2262541 aatttgatca gcagccgttc aaatgttttc attggagcac ctccattaca aatagtatgg 2262601 aagtgtttgc cgatgtttat tccattcggg cctttcttct cttatttaac tggcgcctga 2262661 tgcagtattg aagcaaagcc tgctggtcac ctgctgcaat ttctgaatac tctaaagtca 2262721 tttttcgttt ttctgacttg gggtcattaa agattcgtct gacaactgct tctgtttcta 2262781 tttgacgtgt gtgctcctct tcaggaagac ggatgatcag gcgcaatgat tcccccgatt 2262841 gaaaagaaag gccatcagct aaaaccacgg cgatgccgcc tgcactgatg ttataggata 2262901 gtgtgcggat ctcttcttca tttcccggct gaatttgcac atctaatacc gcatcagttc 2262961 ttacatattg gcggcgctgg attcttttca ttttttcacg gggaggcatt tcaagacaga 2263021 tcatttgaag tttgtccttc actttacctt ttatacggct tataaagcga taaggaactt 2263081 cgtcttttcc cacaaactct accgttactt ccatatcgtt atgtaaaatc acagttcgcc 2263141 ctgtaactac atcaacagga tacgcgatca aaagttcatt gttttcgatg ctgaccgcct 2263201 tgctttttgc ctttttcaat tcattttctt ctatatattc taaaagtaca ttttctccaa 2263261 tctctatcat tgacttcact ctttcgcatt caatatactc acgtttttat taaagcacgt 2263321 aatgaaaaaa aggaaaagac atttagtcct ttcctcctgt ttttataggt ctttatatat 2263381 aggttctgca ttttttagtt tttcaacctt ttcttccgat ccgtctttgg cattgatata 2263441 cattctgaat gtgtcatttt caattgtccc aagcatttcg tagcataaca cttcttgacc 2263501 tagttcattt gtaatcaaag cgagccttgt ttctctcact tgtacatttt tatttaattt 2263561 agactttgcc tctgcttcag taattgcagg cttaggtatg gttctttttc tgtgagatgt 2263621 gaggaagtct cttgctgaaa agccgacaac ctcaccgtca tccaaggcca ctttcatacg 2263681 aattgcctcg gggtacatcc ggactttatt ttcaacagga acatatgaaa atacaccgat 2263741 tttatcatat tgggcacttt catcaatttc caaatcatct gtttcaaatc cgtttttctt 2263801 taaaaatgca agcgctcggt tcgatccgtc atttaaactg attttctgat ctttcacttc 2263861 tctgttttgg atcaagtata ccggatgccc gcccttcttc gtaatatcca tataaatcac 2263921 tgctttatgg tctgggtctt tcatgctgat gctatataca tcgcgatttg ttttttttcc 2263981 gctctttacc actttaattg aataattgtc atctggggca aagcgctcag caatttgttt 2264041 tgcttcctgt tcggaaattt gttttccctt cagatggctg aagcctttct cttctttttt 2264101 cgtactggtg aaactcgggc caagatcagt gccagtggag aatgcaccaa catttttttc 2264161 gactgtttta aagctgttga taatcgtatt atcactttgt ttttcgtcag aagccagagc 2264221 catttctacg tccatccagc gaaggttttt gctcatgaca aggtgctgaa catgacgcaa 2264281 ttcattttgt atatcttcgg actgctgata tagcttattt agtgatgtat actcgttttt 2264341 atcaagcggc ttttggtcca aatctctgac tgacgtttta tagctgaaat cgccgatctt 2264401 tgataatagc tcttcagttt tattaaacgg cattaatgta agcggcagct gactgacgct 2264461 gttatgagct tctgatgtaa tcctccacac atcgatcaat gcaggcgaca gtgatttttg 2264521 gctgttcatg gcaagtgttg ttccgatttt atcatgaagc tgatccacct gataggtaag 2264581 ctcatgaaac gcccgctgat agttattttc agcatgaaga agaactgcgt ctttttcctg 2264641 gtgttctttg tatccccagt agcctgtacc gactattgca ataccaagca cggcgattaa 2264701 aattcctctg atcatttatc acacctcttt ttatgctttc tcatatctgc tactcacaga 2264761 aaatgtgttt accgattctt ttaatctgcg gacgccccca aatccacgga cttgtagccg 2264821 tatccggatt aaagtagtaa agtgcttcct ctgatgggtc ccagccattg atggcatcca 2264881 gcactgcttc tcgtgccgtt tcattcggct gcatgtaaat ttgtccgtcg gctactgctg 2264941 tgaaggcaag cggctcaaaa ataacccccg ctactgaatt tggaaataac gggctgttca 2265001 aacggtttaa aatgactgct gcaatagcaa cctgcccctc gtacggctcg ccccgggctt 2265061 cgccataaac cgcttgagca agcagcctga tatcgttgtt ggaaaatcca ccaggcatgt 2265121 tcgctgctac cgcatcctgt tttcttgctt ttgctggtgt attgttttgc tgtttattcg 2265181 cattcgcttt aggcttctgc gttgtttttt ccgcaggctg tttctgccgt gcttctgctt 2265241 gttgtcttgc cttttgtgtt gctgcttttg atggtttcgt ctgatacttt agcggaattt 2265301 ttccgtaatg cgtgaatgta ttccctttat tgagctgttc catgacatat tcacgatagt 2265361 attttgattt acatattaag gtttgctttg ttttagctcc tacaaggccg tcaacctctt 2265421 ttaacccgaa ttgatcctga aaatttcgaa ctgcccagta cgtcccccat ccataaaccc 2265481 cgtcaatttt tccgttataa tatccgttgt attgaagacg cgcctgaagc tcgaccacat 2265541 catcccctgt tgcccctctt tgaatgacct gattcgaaaa ggcagagatc gtttcagtat 2265601 taataaacgt cgttattgta aaggaaaaaa ggatgagaca tgccataatc gatcctttgg 2265661 acttcatctt ttcaagcctc ctactgcaaa tttttaagtg taatcgtatt ttctgtaacg 2265721 aggttatttt tatacactct ttccttgtta tccctcagaa cataaaaact gcacacaaaa 2265781 aagccgcacg gttgctgtgc ggcttctata cttgcatcat attaacggaa cgggcttttt 2265841 tcgctttacg caaaccaaac caccataaaa ataccataaa tggaagcata taataaatcc 2265901 aattgctaag cgctgttagg ataaaatcat atgatccatg caaaagggat gggacaacta 2265961 aagaaagagt aagccacttt acacgcgcct tatcagcgga aaaacgggct tttccaaggt 2266021 aaaatcccat tataacgcca atcaaggcat ggcatgaaac aggcagcagc gccctgacaa 2266081 acgcatgctc cacgccgtgg ccaattaaat aaagaatatt ttcgagggtt gcaaaaccga 2266141 gtgatacact tgcaccgtac acaatcccgt cataatgctc atcaaagtgg gcgtgcgggt 2266201 aaacactgat catcagtata aaccatttta atgattcctc caaaaacccc gaagataaaa 2266261 aagaaacgaa aaagcttccg cctcctacat tctctttttc aagtacatac tggataaaca 2266321 tgatgggaaa tacaagaaca accccgagaa aaaacgaccg tagcaccata tgtacaggtt 2266381 cattatcata ctgatctttt aaataaaaat aacttaataa cgcgatgccg ggggcaattc 2266441 ctgcagagat gattgcaaac atcaggcaac ctctttcctt tatattccta catctatcct 2266501 accatgttgt ttaaaatttt acatctgtct gcacttaaaa aaacaaaaag agcatacgaa 2266561 tgcatcatat gctcctcatc tttaatggtt ttctcttttg gcgatttccg ctgcgatatg 2266621 ccccccgtga aacctgccgt tttcaataaa tatttcattt gcattgtttc ccgcagcaat 2266681 aacaccggca ataaagacac cttcaacgtt cgtttccatc gtttcttcgt tgaaaaatgg 2266741 acgccctgtt tctttatcaa tttcaacacc aattttttca agaaattgat gatcgggatg 2266801 atagcctgtc atggcaaata caaaatcatt tttaatggta atgagttctt tctctccgga 2266861 gcgaaacaca acttcattct cggtgatttt ttcgacacaa gctccaaatt ccatacggat 2266921 tgtaccgttt ctgacgagag cttcaaattc cggcagaatc cacggcttaa tgctcggaga 2266981 atactcattg cccctatata aaactgtgac acgcgcccca gatttcacga gttcaagggc 2267041 ggcgtccacg cttgaatttt tcccgccgat gacaacaaca tctttatcaa aatacgggtg 2267101 gccttcttta aaataatgaa atactttcgg caaatcctca ccgggtacgc ccatatagtt 2267161 tggatgatca taatagcctg tggcgatgat acaatatggc gtcgtgtagg tctcttttga 2267221 cgtctcaata acgaatgtgt tattttgcgt tttcgtcact ttacgcacca tttcaaacgc 2267281 attaacacgg atgtttttcc gtttaacgac ttcccggtaa tacgataaag cctgaattct 2267341 gacaggcttc ctgttctctg taataaatgc cacatctccg atttcgagct tttcacttga 2267401 actgaaaaag gtttgatgcg tcgggtaatt gtaaatactg ttaacgacat tgcctttttc 2267461 gatgacgagg gcatcaatgc caatttgttt taggtgaatg gcagcagata gtccacaagg 2267521 tcctccgcct ataataattg ctttttcttg aatcatttct gtcaactcct gcgattggca 2267581 tttcacttca tattttctat ttccgaataa aaaaatctcc tattttatca taggagattt 2267641 tttattttta tgcaaatcat caacttatat ccagcctcta aaacgcgaag cttcagccat 2267701 tttgcgaacg ccgaccatat atgcagcgag cctcatgtca attcttcggt tgttagccat 2267761 ttcgtaaata ttgttaaatg atttgaccat cattttttct aatttttctt ctacctcttc 2267821 ttcactccag tagaagcctt ggttattctg aacccattca aaataagaaa ctgttacgcc 2267881 accggcactt gccagcacgt ctggtacaag cagaatgtcc cggtctgaaa gaatttttgt 2267941 tccttcaagc gttgttggtc cgttcgctgc ttcaacgaca attttagccc ggatattatg 2268001 ggcattttct tctgtaattt gattttcaat cgcagcagga acgagaatat cacaatccag 2268061 ctccagcagc tcttggttgg taatggtatc gttgaaaagc tttgttacgg taccgaagct 2268121 gtcgcgtcgg tcgagtaaat aatcgatatc aaggccttcc ggatcataaa gtccgccata 2268181 cgcatctgag atgccgacaa cttttgcccc cgcatcatgc ataaattttg ccaaatagct 2268241 tcccgcgttt ccgaagcctt ggacaacgac acgcgcacct ttaatatcga tgcctctctt 2268301 cttagccgct tctttaatac agatggtaac accttttgct gtcgcagatt ctctcccgtg 2268361 agatccgcca agcacaagcg gtttgcctgt aataaatcca ggcgaattaa attcatcaat 2268421 tcttgaatac tcatccatca tccaagccat gatttgtgag tttgtaaata catccggtgc 2268481 cggcacgtct tttgtcgggc cgacaatttg gctgatcgct ctgacatacc ctctgctcag 2268541 acgctccagc tctctaaacg acatatccct tggatcacaa acaattccgc ctttaccacc 2268601 gccatatgga agatcaatta tgccgcattt taaactcatc caaattgaaa gcgccttcac 2268661 cgccttcacc tctttttctg ttacgttcgg gtgaaaacgt atcccgcctt tcgttggacc 2268721 gacagagtca ttgtgctgcg cacgatatcc tgtgaaaatc tttactgaac cgtcgtccat 2268781 acgaacaggt atttttaccg ttaataatct catcggctct tttaacaatt cgtatacctc 2268841 ttcgggatat cccaattttt ccagagcctt atgtattacg gtttgggttg attttaatac 2268901 atcaagtttg tcctcttctg tatgaccggt gtttcgatcg gctgccattt gagttaacct 2268961 cctagaatct tctgtttctc acatgctccc tttcagagaa tagtatacac cttcatatga 2269021 tctgtgcata gaataaacgt tatgtttttc catgtttttt aacgaaaaaa aactgctgaa 2269081 atcagcagtt ttccgttgca ttcttatgaa aaatgagttt gtatcgtttc tacggcatta 2269141 ccgtccataa tgagcttacc atactcttgc aggcgataaa tcgttaaagt tgtcggattg 2269201 ccgtattcag ccagaaccgc cacaacccct tcagccgtat gtgaccctag atcttcaagg 2269261 cttaaaaagt actgcccgtc atagtggtag acagttcccc ctgtgatacc gattcgctgt 2269321 aagctttctg aaagctgaat gatatcttca aaggaatgga attgatatat gatgtccgcg 2269381 ctttcatcaa gcttgacttg catttcgatg taatcatcat catactcatc gtcttctgaa 2269441 tcggcgtctt ggttctttgt tacaatcacg accatccctt gtgcttggag agaatacact 2269501 tccactgcaa tcggtccatt cgcttcaaag ccgagctctg tatttgcttc attcatcata 2269561 tctttaaata actggtggac tttaaatgag tccttccaga ggtcttcttt tgtcaatccc 2269621 cggtctgtca aatcatcgag ggttaaaaag attttgatct tattataatt cagacgctca 2269681 agccgcataa cgttccctcc tgcctctact tgcacacaaa tcatataaca cattatatga 2269741 gatgatgagt cataggttct taattgttat cagtttacac tgagttcact agtaagacaa 2269801 gcacaatgca gtttttattg ccatacggat ttttgctttt tagaagttat tctggcccgc 2269861 aaagagtcac aatgtgagtt tcaggctcag cacctaaacg aagaggcact tttgtcgtgc 2269921 cgtagccgtt gctgatcaga tatgccgcgt ttttaacaat acctgttttc cccagttcat 2269981 aaggaccgaa ttttccaaac ctgatctggc ctccatgggt atgtccgctg agtatcacat 2270041 caataccgtc atcttcattg atttgttcat gaatctccgg attatggcaa accagaatat 2270101 tcagctggct ttcatcaagt tctttgatgg cttcctcata atgatccatc tccatcctga 2270161 tatcatcaac ccccgcaatc gcaatcgtat gcccattgta tgaaaacggg actgactcat 2270221 ttctcagagt gatgacgccg tgcgctttaa atatggaata cagcttatgc tgcctgactt 2270281 cataatcatt attcccccac acaaacacga tagggacccc gaaatgtacg agccttttga 2270341 tgttttcctc gattctcgca ctgggcaccc cgccctcagc taaatcaccg ccgattataa 2270401 ccaagtgggg ggcatggctt cgcgcttttt ctaaaaggtc ttgatcgatg agacgtttgt 2270461 gaatgtctga aataaaaaag attgtcagag gcggcttgcc cttcatcttt gataaaggaa 2270521 acgtatgtgt cttcaaatga ttgccttttg ctgttgcata catttttgcc gtcattgccg 2270581 ctgccgcaac agttagtaca ccggcaattt tcactgatag cttcataaaa aactctccat 2270641 tctttttaga acttatcaat aagacggaca ataaaaaaag acgtttctat cgtttgagaa 2270701 aacgccccat tttatttact ttcaaaatat agattaatgt catatttgtg cttcatcata 2270761 tgaaaaacag actctctcgc cttccattta tcgggctgcg gccagagatc agtgcttttc 2270821 tgaataattt cacatctcag tttatggaaa tcagtctcgg atttttcttc ctttttcttg 2270881 aaataatatg aagtgcagta ggcaaaagcg gttgccagca tccaaaataa ataaaaggta 2270941 tggctaagta tttcttgaag tataagctga ggctccgggc ttttgatcat gatcataaca 2271001 cataataagc ctaggcagat aagtgaagcc catcgccatc tgcggcattg tgctgcataa 2271061 ttttcgaatt tttgttttcg ttttaccagc gcttggagca tctgtttggt cggcgcgtct 2271121 gtaaactgat ccagctgatt ccataaggat tccatacgct tcacaccttg tccattttca 2271181 ttgctacaat atatgaacgt aaaataaaaa taatacccta ttcatccatt aaagggatgt 2271241 ccaaaacttg tccggtgtaa acatcatttc cattcagatg attatatgct cgaatttttt 2271301 cttctcctgt ccggctttta taatacttca tggaaatgcg gtatagcgtt tctttctttt 2271361 ggacggtgtg cttgacaacg cgattcggca cattttgaac tggctcagct ggctgttctt 2271421 gctgttgtac tgttgattgg gaagaggaag cagccgcggc ggttgcttcc tccttatttg 2271481 gcgagtcttc tttttccgct acagcagtct gtttcttatc agcagctgtt tgctcttttg 2271541 gcttggaatc ttctggctct ttttttgact ccttctgcag tgcggtttct ttagtgtctg 2271601 cggtatcgtt tttatcctct gatttcggga caacctcata tttgctttgg ctgctgtcaa 2271661 taaaaacatc ttcataatcg tcatgattat ccgggtggct ctttagataa aataaggtga 2271721 ctaaaacgat aaccggcaca aatacaaata ttactgcgag tactgtgaat aatggcgttt 2271781 ttgttttgcc ttgctttttt ttctgttctc tttgattttt tacagattgt cttgtcggaa 2271841 ggctttctcc atcatcgaca taatcgtccg ccaatgcggc gttttgatct tcataaagat 2271901 tctgggcttt tcttctctct actctcgaca tgttcgtcat gtttatccct cctcacatgt 2271961 tcaaaacgaa tctgacaggc aaacacggca tcaatgataa aatgcgccgt catcggaaca 2272021 aataagttgc cggtccattc atacatcaga ccgagcaaaa agctgattgc tgtcaccata 2272081 ataaataaca gccattttga caaataccga aagtgcagag cggcaaatat aaggctggcc 2272141 gtccataaac cgatatgagt ctgcagcact cctctgaata acatttcttc cgcgaaagca 2272201 atcagaagcg ttaaaaatat aatatgaggg attgacctct tactgaatat ttttttattg 2272261 attccgccgt catcatataa atgagacgga aaccatttca ttactgccat atcggctaaa 2272321 ataacaataa cagctataga aacaccatac cagatgattc gcatatcgcg aatgtcccag 2272381 agctttaata cgtcccgtac atcctcaaaa aagaacagtc ctgctgcagc agcggcaaag 2272441 atgatgagta gctgcgtcaa atataactgc ttcagcatat catggtcagt catatgctga 2272501 atataatctt tttgctgttt cagttcagct cacctacagt ctgcaagctg aatatccggt 2272561 gcaattccga actccagctg tctaatggcg ccattttact ccgttcccct ttttgttcat 2272621 acaaggataa atcaaaaccg caatgtgaac agcacgggag gtttccgtca tcaggctcgt 2272681 atgattcatc aaagtaggtt aacagtgcct gccttaaaca gccgtcacgc tgaagcaaaa 2272741 atgatacacg gtgcattttt tccagcttca gctccatgcg atatgaaatt tctttcttca 2272801 tcagttcaac tgatgttttt ccctgcataa agagatgaat catcatacgg gcctgtgtct 2272861 ctccgacgcc atactgaagt aatacgtcac gcagccttct ctcatcccgc tcctccgtct 2272921 tctctagcac acggattacg tcggcgattt cttcagctgt gacactctcc atctggataa 2272981 tttgttcctg caattcaaaa tcccctggcg cccgcagcaa aatgctgaca ctcggctttc 2273041 cgtcgcgtcc cgctctgccg atttcctgca taaaagcttc tgccgtctgc gggagatgaa 2273101 aatgaatcac atatctgata tcaggtttat cgacacccat tccaaacgca ttcgtacaac 2273161 atatcacatc aagctggtta tgaataaact gctgctgaat taaaatcctg tcccctgact 2273221 ccaaaccgcc atggtaaaag tcggctctgc tgctcgtttt gcttttaatt tcacccgcta 2273281 attccttagc ccatttccgt gttggacaat aaacaattcc cggaccttgc aggttttcaa 2273341 ccagctgaat gaccctatct attttttcgg cagtatccgc cgcattttca accctcagtg 2273401 cgatgtttgg gcggttgact gagttgagat ggcgtacagc atgctgcagc tccagcaggt 2273461 tcatgacatc ttgcagcgtt tcctttgtag ccgtggcggt caatgccaga acgggtgggt 2273521 gtccaagttt ttttctcagc tgtccgagct ttgaataatc aggcctgaag tcgtgtcccc 2273581 attcagaaat acaatgcgct tcgtcaataa caaataggct aatcggaacg cttttcaatt 2273641 tttccaatac atatggagac tgtaaagctt caggagacaa gtacaaaaat ttatatcgat 2273701 gaatatgttc taaaacaaat tgtctttcct gcctgttaag catgctgttc aaagctgcag 2273761 cacgcttttc cccccgggct ttgagctgct gcacctgatc ctccattaaa gaaagcagtg 2273821 gagaaacgat taataccatg ccatcaagca tataaccagg cagctggtag caaagcgatt 2273881 tccctccccc agtcgggagc attgcaatgg tatccttccc gctgagtatg ctttcaataa 2273941 tgtcctgctg ccctttttta aaggaagtaa aaccaaaaaa ctgatataac gtttgctgta 2274001 atttagtcat attgctgcac ctgctttgtc aatgccagtc tgatttgaaa gtagctgaac 2274061 cgctgttcca gcccgtcgcg aatttgtttg attttattcg tccgcatccg tttggcaaac 2274121 tctgcgattt gaagctggtc ttctgctgat acatagtcat taatcataaa cgcaggctca 2274181 tggagagaaa tctcgacaat gtggtcttca atcgtcgctg ttttcagctt tctgatttca 2274241 gcaattcgct gtatcggaaa cccttgtttg accatctgcc atgttttcct cgtcgactct 2274301 gtcagggcat tatctaagtg cacatcagaa aggagatcct ttaacaaagc atcttcacac 2274361 tccggaagag aatgaataaa ataatgtacc gaagcccaaa acatgatata gacataccat 2274421 tcgtcttctt tcagcgtatc agcaagctgc ctgctcgtat aaccgatccg atggtgcgag 2274481 gttaaggagt agacaaaaat ttgcgctgct ttgttttcaa tctttttcaa atgcgcctca 2274541 agcatggcaa aaaggctttt tgccatctct atatgatccg tatgccggga caggtatttc 2274601 tttacccagt gaagtgtctt atgatccttt gtgacaggga tatactgcct gctcccttgc 2274661 tgtttatggg ataggacctg cacaagcagc gaaagccttt tccaaagcac gccggcagcc 2274721 tgctgataat gagcgccgtg acaatgaacg ggccaaggcc gctcgctaag ggcatgtctc 2274781 aaaactgctg cgccgctggc tgtcactttg tatgtatctg attcagacat tggcgcgaga 2274841 tatgaatgct tttcaagctt gtcaagcgac gcagaaatat cgcttctcga acattttgcc 2274901 gccattccaa agtattttgc agtctgaaat aagccggcat cttgaatggt ctgtgacgat 2274961 ctcttgcctt tgaataggtg aaaaacagcg cttcccgacc gttccccgtt tattttgcaa 2275021 agacaatcga gaaccataat atcgaagtaa tttaatgaca acctatccac ctacattctt 2275081 cctgacaaaa atcgttgatt tgctcttttt attttaacag atttcaaaca gaaatcgacg 2275141 tttaaagtca tcattaaggg ggatgttatg tagataaccc cttatgtgat aagcattctc 2275201 aatcattttt ctgttgaaat gtggcagcaa catcattaca ataagtaaga ggaataggtg 2275261 ttaaattgat taaatataaa gattgatcca tttgttccac caagaacaat ctgggaggtt 2275321 ttattcatgg caaagtacac aatcgtagac aaagatacat gtattgcatg cggcgcttgc 2275381 ggagctgctg caccagacat ttacgattac gatgatgaag gcatcgcgtt cgtaacgctt 2275441 gatgaaaaca aaggtgttgt cgaagttcct gaggtactgg aagaagatat gattgacgca 2275501 tttgaaggat gccctactga ttccatcaaa gtggcggatg agccatttga aggcgacccg 2275561 cttaaatttg aatagaagta actaaaaaaa gctcccgaac gggagctttt ttatttaatg 2275621 gatatgtgca cttcgctgct gctcaatcca tggcttaagc ttgataaaaa ttagtgagaa 2275681 tacaaccgta attacaatac cttttatcat gttaaacggc aggatacctg cgacgactgc 2275741 tgtttttagc gcgctgtcgg ataatgccgg tgaatgtaaa aaccacgtgt atgccggaag 2275801 aatcagaaca taatttaaaa tactcattaa aatggtcatc gctgcagttc ccaaaagcag 2275861 gctgacagcc aagccctttg ctgagttgag ttttttaaat aagaaagcag tcggtaatat 2275921 aaagagtgtt cctgcaataa aattcgcaac ttgccctaca ggaactccgg ccatgcttcc 2275981 ctgaatgata tactgaagaa cattttttat cgcttctacg gcaatacccg ccaaaggtcc 2276041 gtaaatcaga atggcaataa ttgcgggaac gtcgctaaaa tcgattttta aataatccgg 2276101 aagacccgga aacgggaaat ttaacagcat caaaacaaat gcaatgctgc tcagcatgct 2276161 gaccacaact aattttttta ctttcacttc attctctcct tttcgatcac atcttactcg 2276221 aaaacggaaa ggttcttttc cagccaataa aaaaaccgct tcatatataa aagcggggtt 2276281 tcgaaaatta ggctaggcaa agaaacgttt gaaaaattca atttcaaaac gcttatgaac 2276341 ctccatcttc tcccatccag actgtactgt cggctccgga atctcaccga atcctgctgt 2276401 aaagacagct cgcgggctta gagccattgg ctcatcaccg ccggtaggga atttcaccct 2276461 gccccgaaga ttgatcatat gaaatttaat tacattataa acgataactg gttggctgta 2276521 tagagaattg cttcaaatta aatatattac ctgcaagctg tcagatcatt gatttattag 2276581 gctttacttt tatcctttac tgcgtcaata cacgttgaca ctcttttgag aatatgttaa 2276641 attatcagat atttagtttg tcaatttagg aggaaatcta acgatgtttc gagtattggt 2276701 ctcagacaaa atgagcaacg acggtttaca gccacttatt gaatcagact ttattgaaat 2276761 cgttcaaaaa aacgtagcag atgcagaaga tgaattacat acttttgatg ctcttttggt 2276821 gcgaagcgcg acaaaagtaa cagaagacct tttcaacaaa atgacttctt taaaaattgt 2276881 cggaagagcc ggtgtcggtg tcgataatat cgatattgat gaggctacga aacacggggt 2276941 aatcgtgatc aatgctccga acggcaacac catttcgaca gctgagcata catttgcaat 2277001 gatctcttct ttaatgagac acattccgca ggctaatatc tcagtgaaat ccagagagtg 2277061 gaaccgcaca gcttatgtcg gttcagagct ttatggaaaa acgcttggta ttgtaggatt 2277121 aggccgaatc ggaagtgaaa ttgcacagcg tgcgagagcg ttcggtatga ctgtgcacgt 2277181 ttttgatcct ttcttaacgg aagaaagagc gaaaaaaatc ggcgtaaaca gccgtacatt 2277241 tgaagaagtg cttgaaagtg cggatatcat taccgttcac acgcctttaa caaaagaaac 2277301 aaaaggctta ttgaataaag aaacgattgc aaaaacgaaa aaaggcgttc gcttaattaa 2277361 ctgtgcgcga ggcggaatta tcgatgaagc agcacttctc gaagctttgg aaaacgggca 2277421 tgttgcggga gcagcgcttg acgttttcga agtcgaaccg ccagttgaca acaaacttgt 2277481 tgatcatcca ttagtcattg ccactcctca cttgggagca tcaacgaaag aagcacagct 2277541 caatgtcgcc gcccaagtgt cagaagaagt tctgcagttc gcaaaaggcc tgcctgtcat 2277601 gtcagctatc aacctgcctg ccatgacaaa agatgaattt gctaaaatta agccttacca 2277661 tcaaattgca ggaaaaattg gcagccttgt atcacagtgc atgaaagaac cagtacagga 2277721 tgttgccatt caatatgaag gcacaattgc taaacttgaa acatcgttca ttacaaaagc 2277781 ccttctgtca ggctttttaa aaccgcgcgt agactctact gttaatgagg tcaatgccgg 2277841 gggtgtcgca aaagaacgcg gcattagctt cagtgaaaaa atttcctctt ctgaatctgg 2277901 atacgataac tgcatcagcg taaaagtgac aggagaccgc agcaccttta ctgtaacggc 2277961 tacgtatatt cctcatttcg gagaacgaat tgtcgagatc aatggattta atattgattt 2278021 ttatccgact ggtcacttgg tgtatatcca gcatcaagat acaacaggtg tcatcggccg 2278081 agtaggacgt attctcggag ataatgatat taacattgca actatgcagg ttggccgtaa 2278141 ggaaaaaggc ggagaagcca tcatgatgct ttcctttgac agacatctgg aagataaaat 2278201 tgtgaaagaa ctaacaaatg tccctgatat tgtgtctgtg aagctcattg atctgccata 2278261 attaaaaaaa ctcaagctat atagcttgag tttttttatt gttctatccc cgtgtgtttt 2278321 tatgcaaaat atctaagaca ctccttagct cagaaacagg aatttggcct ggtgcggacg 2278381 cctcttctcc agctccaaaa gtacaagccg atccaaaaac ctcaccgctc agcctgctga 2278441 tgagccctgt tgcagccatt gacattgtaa taatggggcg gtctgcatat attgttttca 2278501 ttgtatacgt cgcatcaagc agtgttagga gatctccagt atcattcggc atgacagcca 2278561 tttttggaat atgcgcgcct aagtcctgca tttttcgaag tctggaaata atttcatctt 2278621 ttacaggtgt tttttcaaag tcgtgatttg acatcaccac atagacgttg ttttcttccg 2278681 ccagcgatac taacgctttt acatttgcat ctcctgaaaa taattcgatg tctatcagat 2278741 cgatgtcttt tgtttggatt gccgattcca gcaaagcaag ataggagctt tcgtccatct 2278801 ccatgctccc gccctctttg tgggttctga atgtaaatag aaatagcttg tcttctaaag 2278861 atttacgaag cttagaaatg agctttgtga ccgcttctct gtcattcgct ttttcaaata 2278921 cgtcgactct ccattcaaca atgtccggat tcagtaattt tactgcctct gcttcattca 2278981 gaatttgttt ttccgtcttt cccatcagcg gaatgatgat tttcggcatc ccttccccga 2279041 tggaaactcc tttaatcgtt aacacgttca ctcgtctcaa atcctttcaa tctttacctt 2279101 gttttattat acacgtacaa cttttttttg aaaatttcta ttatatgaat agcaactaaa 2279161 aaagagcctt aaagggctct ttttagttta aggaaatcgg atttggagca gctggcaccg 2279221 gaattgcatc tgatatgtca tatttgccga tttttttcgt tctggtttcc gtaaaggtca 2279281 cttctgtgaa gccaaactct tttgcagtca aaagtagtcc ctcaatcatt aaaataccgg 2279341 caatagaatc atcaacttct gactcctttg aaaagcggat atataagtgt ttctgtttct 2279401 tcgttacaga ttggacagca cccgcttgaa taagaggtgt cgtatcttct tggctgctcg 2279461 attccatttc cttaatcgct tcttttactg tatcaaaaga atgatttgac ggaacgagaa 2279521 agtcttgtcc ttgtttattt tggtacaagt agtaggatcg ttttgactgt ttgggaatcg 2279581 aaatttccgt aaaagtgcca tatgagccaa tccgaacccc agtctcattt tgatccgata 2279641 aaaatttgac tttttcataa ggactccatt ttaaggattc tttaagcaat ttttttaaca 2279701 gtgtatcatc ttttatagaa aatgccgtag ctggctgatg gactcgtata cttaattcct 2279761 tctgctttgg tttttccttt atttctactt catctatgaa ggttggaatt gtaatggcat 2279821 gatcaaggat gcccaattca ctactttcaa acagcatatc ctggatcgtt tggtctgcat 2279881 ttgttttttg aatgctgacg ggtatgattg cagatgtatc ggcatcagca accgctacag 2279941 tgatgtaatt gtcttgttcc ttttcaggaa cgacaaacga tgtctgatcc aaggacgatg 2280001 cagcttttgg gctgtcttct gtctcagttt tcgttactgc gttctcttgg gacgcttctt 2280061 tttgttgagg ctgtgcctga tcaaagaaat gaggagaaat aatgaaggcg atataaaccg 2280121 caattgcagc ggcacacgcg gggccaatcc acctgacagc gggcttattt ttacgctttg 2280181 ccatcgtcag ccgcttgtaa atatcctgag gcgaacgatg gtctttaact gccggaagtt 2280241 gacttaacaa ctcctttatc tgttcttcgt tccattctga cttcatcatc cattagctcc 2280301 tccctcaaaa gctccatatg tttccgaagt actttgagcc ctctgtgttg ggtcgttttt 2280361 actttgcttt ccgagaagcg cagagccttg gctgtttcct gtattgaata tccctgaata 2280421 aaccgcaaga taatcacagc tctttgatcg attgtacatt gatcaagcgc agcataaatt 2280481 tcccggacat tttcatgttg aaccgcaagt tcgtccggca gcaattgctg atccctgaca 2280541 tcctgtgtat cccagtcaaa tgtaccgagt atacgctgtc tgattgtttg ctgtttacgg 2280601 aaccagtcta tcgcaacatg gcgtgcgata gacaaaagcc atgttttttc actgcttctt 2280661 ccttcaaacg tatgataaga atttaatacc cggatataaa cctcttgaag aaggtcttct 2280721 gtctggtttt tatcctttac catataaaat aaaaattggt acaaatcttg atgatatgta 2280781 tcatataata attgaaaggt ttcttccatt tgaaacccct ccgttcactt ttttgtcgta 2280841 tgaatagctt gaaaagttac attacaacta tattacgagt aactggaatt tggaagggaa 2280901 tttatattaa catatcctta aattttatta atgttggcta ttaaaaaaac acccgctcag 2280961 tcagcgggtg tttcttatgg aacaagattc ttcggcaaat tcagactcga ttttaccgtt 2281021 ttgtcggaat ataaaaagaa aatgttgttc ctttatctat tcggctgtgc acagtaattg 2281081 atccgttgtg ggcttccacg atatttttaa cgatagccag ccctaacccg gttcctgctc 2281141 tgccccttgt ccgcgcttta tctgccttat aaaaccgctc aaagataaat ggcagatctt 2281201 cttccggtat gccagacccg gagtctttga tatcaatttt caatccatcc ttcacagaat 2281261 ggactgaaat ggagacactg ccgccggctg aagtatgccg cagcgcgtta tcaatcaaat 2281321 tggtaaatac ctgctccatc ttgtcttcat caaacataaa ttcctcttct gtgagagaaa 2281381 tgtcatgatc taaagcaata tttttttctt tcgcaacacc ggaaaacttc cgaatgatct 2281441 tttctaaaaa ctcattcaca ttgatttttt cataatgtaa gcctgtatgg cctgattcca 2281501 ttcgggctaa atcaagcaaa tcattaacta aacggcccat tcggagcgat tcgtcataaa 2281561 tgatttgggc aatttctttc cggtcttctt cagagcttgc aatgtcatcg acaattgctt 2281621 cactgtatcc ctgaagcatg gagatcggtg ttctcagctc atgactgaca tttgcgataa 2281681 agtcctcccg cagcttatca aggcggcgtt cttctgtcat gtcacgcagt acggcaaccg 2281741 ctcctctgac gtgcgattcc gcataaagcg gcgacatcaa aagcacccat gatctgcctt 2281801 gaagcgtcat ctcaatcatt tgttcttttt cagtgctgac agcgttttga aacagctctt 2281861 ttgcttcagg cggaagattg tcgccttctt tgatattcat gttctgttca taataccaag 2281921 cctgaagaaa acgttcagcc ggcgggttgg tcacaagaat cgtaccgtca atattaatgg 2281981 taataacccc gtcagccata ctgctcaaaa tgttagaaag ctgctctttt tcttgattga 2282041 gcgcattgat atgaaagtta agctgccggc ccatttgatt aaaagcggtc gccagttcac 2282101 cgatttcatc ctgagttaaa atcgggattt ttgtatcgaa cttgcccttc gccaaatcct 2282161 gcgcgccttc tctcattttt cggagagggt acgtgaccct gcttgataaa aagaatgcga 2282221 aaaatgtggt cagcacaatc gcaattccag cggcaagaaa aatatagcgg gtcgtatgtt 2282281 ttgttgtatc tttaacggca agcaaagact gggataaaaa gaccatgcct ttctttccgt 2282341 ctttttcata cgggacacct acaatcaggc gttcattatc cgtgtctgta tcgctcagtc 2282401 ccgtccgttt gcttactttt ttatggtctt tgagagcttt atttaagtct ttgtcatgct 2282461 gtatttgctc aaccgtaata gacgacaggc gatttttatc attcggagaa taccagtggt 2282521 tcttctcatc ctggatgatg gcaatgcttg ttaagttatc agcgagttcc caagtgattg 2282581 accttgccag tgcctggtcc tcgtgatttt ctaggatgac agcaacttta ttcgcaagct 2282641 gtgttaaatc attctcagct tcttccacat ggtagttttc aataaactcc agcaaaagaa 2282701 ccgttaaaat gaacaatacg atcaagacga gtgaaaggat cgtaaaccac agcttgccta 2282761 ctacgctttt ccaaaatttc attcagcgcc gacctcaaat ttataaccta caccccatac 2282821 ggtgacaatt tttttcgcag cttccggaga taccttgttc agcttctctc tcaagcgttt 2282881 gacgtgagtg tccactgtcc gtaaatcacc aaaaaactca tattgccaca cttctttcag 2282941 aagcttttcc cgatcataca ccttgtcagg cgttttcgct aagaaatata gaagctcata 2283001 ctcttttggc gtcaggctca cttctgttcc atcagctgtt acgcggtgag catcatggtc 2283061 tattgacaga tgtgaaaaca cgagcacatt tttcgtcggt gtattggcat tgaaataaga 2283121 ggtttgggat gctcttctca aaagggcctt tacacgcagc acgacttctc tcgggctgaa 2283181 cggcttaaca atataatcat ctgttcccgc ttcaaacccc tgcacccggt ttgcttcttc 2283241 tccttttgcg gtcagcataa taatgggtgt cgcttttttt tcacgaattt gccggcacac 2283301 ttcaattcca tcagtccccg gcatcatcag atcaagcaaa attaagtcat aattggcttc 2283361 aagccctttg gcaatggctt catcaccatt ttcagcttca tctatagcat aattttcacg 2283421 ttcaagatac attcttaaaa ggcggcgaat tctggcttcg tcatcaacta ctaatatttt 2283481 tgtttcgttc gtttggtcca tgttttcccc ctgctttcct tctgttactt tcattttatc 2283541 aaatcgtgag aaagtttgag aactgtgtcg ctttcaaagg actatgcata agaatgaagt 2283601 ccggcaagca caagatttac gaatattaaa ttaaacataa taatagcaaa accgattacg 2283661 gccagccatg ctgacttctc accgtgccag cctcttgaca gtcttaaatg caagtaagcg 2283721 gcatagaaca aaaatgtgat cagcgcccat acttccttag ggtcccagcc ccaaaatctg 2283781 gtccacgcga gctgagccca aatcattgca aagatcagcg cgccgagtgt aaagatcgga 2283841 aatccgattg atacggccct gtacccaacc tcatccacca gatcaagatt gacgtttttc 2283901 accagcggat gtaatagagc gctgattctt tttctgatga tcagacggag agccccatac 2283961 aacacaagac ctgctccaaa tgaccaaatg acagtgttca cttttctgcc tgagaaaagc 2284021 gcgggaagat caacaagcgg ttccattctt ccttcggtca aaagctctcc ctgatgcgga 2284081 ccgacaagcg cgggcatttc gtacaccatc acgctttttt ctttactttt gtccacccag 2284141 ttaaactccg cttcatagcc tgcaagacga aatgccgatg tgattgcaat aaaggcgacg 2284201 gttgtgacca ggataaacat aatcgcttca agccagaagg tctttttgct tggctttgtc 2284261 tggtctacat gcttcaaaag aaagatgaca ccagcgacaa agctgatggc aagtatagct 2284321 tgcccaagcg cggccgttgt tacgtgaata tacagccagt tactttggag cgaaggaatt 2284381 aaaggcgaga tatctgtcgg aaacatgctg gcgtaggcaa tcagcaataa agcaattgac 2284441 agcgtaaaca ggcctaatga aggcaatcta tagagaaaat aaagaatgat aaacgccaaa 2284501 acaagcatca tgccaaaagc ggtggtgaat tcaaacatat tgctgacagg cgcatggccg 2284561 cttgcagccc accttgtgat gaaatatcct aggtggcaga aaaaaccgac aatagaaagg 2284621 gtgattccaa tgttggccca tcggtttggc ctgccctttt tatctttatt cccgcgtatg 2284681 gccccgccga agattgggac agcgattaaa tacacaagaa aggccgcata aagaaaattt 2284741 ccgctcagct ctgccatgac atcactccct tttcgcctat ttctgtgttt tgattaattc 2284801 tttttggtcc accggttcag tcagtccgga atcagccaat ataaatgcta aatccttctt 2284861 caggccaaac cagtttttat tggtatgccc tgctaccata actgcaccgt cctgtgagtg 2284921 cagccaaatt cttcgatgct gccagtacat accttgaatg acaccgatca taaaaatggc 2284981 tccgccgaca gcaagcaccc agagtgtcag atcctttctg actgtaagtc cagtaatgtt 2285041 tttcgtttcg acatggtcaa atttcagctt gtatttatta ttgcctgatc cttcgatggt 2285101 ttcttggatg gcgacaaagc tcttttcgcc tttcggtttg tccggcgtta tgatattaaa 2285161 gacaaaagcc ggattgttag ggatctttgt ttttgtgctc ggctctccgt cctgattaaa 2285221 atagaagtca ggcaggtagc tggcgatttc caccttgtaa ccgttaccaa gatcatagac 2285281 tgaatctgga tccagaaggt tgatcttcag gctcccaaag gatttttttg tttttttatc 2285341 aatcagctgg aacaccattt ggtcaagctg attctctttg taatccacct ggtaaacgga 2285401 aaaagaatca aaacgcagcg gctgattgac acggatgtct tcttctgtta ctttttccag 2285461 cttcggcttc tcgccataaa caatttttcc ttctctcttg tagagtacgg catcagtttg 2285521 aaagttcttt gccactctac cgtccccgac tctgtcaatg gcatctgcaa ataccttttt 2285581 ttccgttttg ctgttatagg tctctacgct gaattgattg tttttcaaat aatattttcc 2285641 gtctgtaccc ggaattgctg cggtttcgcc ttctctgacc caaagcgtct catcgacgta 2285701 catgccaggc acaaatctca gcatcgcacc aatcagaaag atgatcaatc caatgtggtt 2285761 gacatacggg ccccagcggg aaaagcgtcc tttttcagca agaatgctgc cctctttttc 2285821 tctgattcta taatgttttt tctttaatag agtaactatc ttttctttcg attccccgtt 2285881 cagtacagta actgtttcac tgaacaagcg ctgccttctt aaaaaggccg ggctccttct 2285941 gacaccttgg ttttttaacg ctctatacaa cggaatgacc cgatcaaggc tgcaaatcac 2286001 gagtgaaatg ccgatcgagg caatgagcag caaataccac caagaaccat ataaatgatg 2286061 aaacccgagc aaataataaa gctggccaaa cgtgccgtac tgctccttgt aataagtatc 2286121 agcctgtgcg cccggaggca gataggcttc ctggggaaaa atggtgccga acgctgatgc 2286181 ggcaagggtt atgacgataa gccatattcc caccttaacc gaggaaaaga aattccaaat 2286241 tttgtcgatg atcgttttgt tataggtttg cgaacgtctt gcgcttccgt catatctcat 2286301 atcagcgagc ggaggttgag tttcctgaag agctcttccg cacgattcgc ataaaacggt 2286361 tccgaccggg tttatatgtc cgcattcaca tttgacttgc ttcatcccga agtctctccg 2286421 ggttttatga gattcatata atcgtgtatc atgctttctg tcatagtgcc ggtcaccacc 2286481 ttgacaactt ttccttccgg attgatcaaa aaggttgtcg gaagcggaga tacgtcatag 2286541 gcatcaagca cttggcgatc tgtatccaga acaaccggga aattgactcc gtaggatttc 2286601 ataaaattat gtactgctat ctttgactcc ccaacattta cagcgacaat ttcaacacct 2286661 tggcttttaa aatgcttata ttggtttgcc atataaggaa actctttttt gcacggttca 2286721 caccatgtac cccagaaatt caaaaaaaca cctttccctt ttaagtcact gagctcgata 2286781 cgtttcccat tcgtatcctc taggacaaaa ttcggtgcgt cggacccttc ggatatactc 2286841 tctttgccgg caaatacagc gttgtaaatg gtatagccga gtgcgcagat taaaacgaga 2286901 aggatgccgg tccgaatgaa taaacgcctt tttttcttca ttgtccactg cccccttccc 2286961 cctattgcag atccattcaa ttatatcatt gcacgttcat ttcacatttc ttactttttg 2287021 aaggttatgt gaaatttaga aagcgttttt accgtgatcc gccagtgctc tgagcctttt 2287081 tacttcgtga ggcgtaagct ctctggcatc gcccgtgtgc aggcctcgca ggtttaaaaa 2287141 cgcgtattcc tcacgcttca gcttgattac ctcatgtccg atcgcttcaa acatgcggcg 2287201 cacttgtctg ttgcgtccct catggatcgt cagctgaata atgcttgtct gctttttctt 2287261 atccaaagac agcagcttcg ctttagcagg cgctgttttg ccttcctcca gcctaattcc 2287321 gcgctccagc tttctgagca gctctttagg cgggattcct ttcaccttcg ccacgtatgt 2287381 tttgtctatt tcatacttag gatgcattag cttattggcg aattcgccgt cattggttaa 2287441 aagcaaaaga ccgctcgtat catagtccag acgcccaatc ggataaatgc gctgcggaat 2287501 atttttaaaa aagtccgtca ccactttgcg tcctttatca tcttgcgctg cggaaataac 2287561 gcctcttggt ttatataaga gaaagtaaac cggctcttcg cgttcaacct ttaacccgtt 2287621 tacctcaatc tgatcagaac cggtgacctt aacacctagc tctgttacta ctttgccatt 2287681 cacctttact tttccttctt taatcagctc ttctgccttt ctgcgcgacg caactccggc 2287741 atgagcaatc actttttgca gtctttccat gtctttcacc tcaagtatta tcttactttt 2287801 ttcaacctta acaaacaagc tttttcaaat tcctatgcca aatctaaaaa aaacgccgtt 2287861 ttcaggcgct cccaaataat aacgtaacga tgatgataga tgcaactacg ccgattaaat 2287921 ctgcaagaag tcccaccttt aatgcatcac ccattttttt aatgccgact gctccgaaat 2287981 acacagtcag tacgtaaagc gttgtatctg tagatccctg catgacggaa gccagcctgc 2288041 cgataaagga atcgggcccg tatactgcaa ttaaatcggt cgtcattcca agtgcggccg 2288101 taccggagat cgggcggatc agagcaagcg gcactacttc agcagggatg ccgatagcgg 2288161 agaaagccgg ttttaaaaga tccattataa aatcaagcgc gcctgatgat ctgaaaacag 2288221 ttatagcgac aagcattccg actaaatagg ggataatgga aaaggcaatt tctatcccct 2288281 ctttcccgcc ttcgacaaac gattcatatg tcggaacctt tttgatcgtt ccataaagaa 2288341 gaattccggc aataatgatt ggaatcatgg ctaaagacag ccagttgatg atttccatcc 2288401 gctcaccttc ccttcttttt gcggcggtaa taaaaatacc gatcaatgat aatggcaccg 2288461 attccggaaa taagcgttgc caaaatgctt ggcccgacga tatctgtcgg cgttttggag 2288521 gaataagcca ttcggacagc gatcaccgtt gtcgggatga gtgtgatgca ggacgtatta 2288581 acagctaaaa aagtaatcat cgaccggctt gcttccgatc ggtttccgtt cagctttttc 2288641 atttgttcca ttgctttaat gccaagcgga gttgctgcat ttccgaggcc gaagaaattc 2288701 gccataagat tagataaaat atagcccatc gccgggtgat ccggcggtat atcagggaac 2288761 agtttagata taaaaggtct gcacatccgg ctgaaaatat ccaaaagccc tgactgctcg 2288821 gcgattttca ttaagccaag ccagaaaaca agcacgctca tcaatccaaa tgagatcgta 2288881 atcgcttctt tcgcaccctt aaacacggct tcatttacat cttgcagagt tccgttgcac 2288941 atcgcaaaaa cgagtccgat cacggttaaa ctgacccaaa ttatattgac cattttgctc 2289001 cgcctgccgc attcagaaag attgatttaa acgtttcaaa aaattgtttc ttcggttttt 2289061 gatgccgctc attttcataa tagatcggca cttttgcgat ggttgcatcg ttgaacatga 2289121 tctccatgtg ccctacgatg tcagggattt tcgaggcatc tttttcccat gcttttttcg 2289181 gcttgagcag tgtggtatta atttttacat tttctttttc ctcttcggtc agcaaatagg 2289241 tgatatcacg tttgataaaa gccttcgatt cataaaatgt gcctttcagc tttggaatat 2289301 cccctttttt tgcaattaaa taggtttgat aatgctcaaa cacatagtta aacatcttca 2289361 tatggtcatc ccaatcatta gggtcattaa tggtgacggc tatcaggtca atgccgtcct 2289421 ttgaagccgt agagaccagt gtccgttttg caagttttgt atagcctgtt tttcctcctg 2289481 tgctgtacgg ataaagcatg gtcagcagtt tgtttttgtt tttccatacg ctttccatcg 2289541 tttccgcttt gtatattttt gtgcctgaaa tcttttgata gtctttcagc ttcatagcat 2289601 acttagttaa aatggccatg tcataggctg ttgaataatg attttcatgg tcgtccaatc 2289661 cgtgcgggtt ttgaaaacgg gtgtttttca taccaagctg ctcggctttt tgattcatca 2289721 tataaacaaa cccatcgagg ctcccaccga catgctcagc aatcgcgaca gcggcatcgt 2289781 ttcctgatct tagcatcagg ccatacacaa gatctttcag cttcactttt tgaccttctg 2289841 ttaaataaat ggcggagcct tctgttctga cagcatttgc cgaaaccgtc actgtttgat 2289901 ccattttgcc ggattcgatg gcgaggacgg cggtcataat ttttgtgatg ctcgcgatcc 2289961 gccttttttg atgctcatcc ttggcatata acactctgcc tgacgcaccg tcaataatga 2290021 tcgcgctttt tgcactgaca tctatagcag catgtgctgt attcacattt acggttgcaa 2290081 taagaaaaga aatcatgatc acgaatactg cttttttgaa aatgcgcatg tttgctcacg 2290141 tccttgtggt ggtttgtaca agtttatgcg catgtccatc agttatgaat aacaattata 2290201 tttctggaag caaacataaa aaaactctcc ctgaaaaagg gagagtaaac gttatctgat 2290261 tggcgccatg cttgatccgg acgcttcgta atgagccagc tcttccctca tcttcagaaa 2290321 ggccgcgctc aacggcaata ataattgctc aagcgacgca ggaacagcat gataaaactc 2290381 aattgcgctg accccggtat aagacgcccg gctattttca caccacgtgt cttttttcgg 2290441 cataaagaac tcttcaatgc attggtgata cacattataa agtgtttttt ccgctctggc 2290501 ttcctgaaaa ggctcctgca tcaggagacg acggcacgct tctgcgcctc cttcacaaaa 2290561 tactgccatt cttctcagag tgctaagcac atcacagcag tatccttttt caataggcaa 2290621 ttcagcctgt aaggactcaa gcgtcgtttg atttaggtaa tcgttcacgg tattgacaac 2290681 cattgataag aattcgcctg ttttttgagt ctgcgctcgc acaatcgaat gtcccatttc 2290741 gtttggtatc ttcccctcat gtatttgtct ctcacatttt gcttctttca tgatagcttc 2290801 ttccttatat cttatgatga tgaaaaagcg cgattcatta aacttctatt ttatatcttc 2290861 gaaggtttgg ttaaagtttt caaaaaataa atctgcttct tcttgaagaa cgtcttcttc 2290921 cgcattttca ggcagcggcg gaagctcgtc cagcgttttc agaccgaatt gttcaagaaa 2290981 agtcggcgta gtaccgtata aaatggcccg ccccggacca tcggcacgcc ctacttcaca 2291041 caatagcgcc ttcgcgacaa gactgtgtaa aatccgctct gattttactc ctctgatttc 2291101 ttcaatttct gctctcgtaa ttggctgttt gtatgaaaca atggccagta cttctaaaga 2291161 tgcttgagaa aggccctttg acggcacttc aatcagtttt ttcaagtaag gcgcaaagtc 2291221 ttttttggta gagagcatgt acgtatctgc atactcaata agttcaatcc ctcgtgtatc 2291281 tccgcggtat tcgtccgcca catccgccat gatcgtgttc agttcaggct cttcgatttc 2291341 aagcactgtt aacagctgct tttttgtaag cccttcatcg cctgccgcat aaagaagggc 2291401 ttccacaata gctttccaat tcacgatatc aagccccatg aatggattca ctccccgtaa 2291461 tgtaaatatc tgaaaaattg tgctcctgtt caatgaggac cagctgattt ttcatcagct 2291521 caagaacagc tagaaaggtc actactaaat gttctttttg ctcatatgga aacagatcca 2291581 taaagttaat tctcgttcct ctagatttca agctgtgcac gatttcgttc attctggctt 2291641 cgattggtat gtcctgtctt gtaattgttg tttccatcgg cctgtttatt tttttgcgtt 2291701 tcagcacttt ttgaaaagct ccgatcatat catagaccgt gacagagagc ttttgctcag 2291761 actgttttac ttcttttgca tattcactca aatcactcgg cggtttcgtg aacgattttt 2291821 gtctttcttc ttcccgttct tttaaatcct tcgccgcatc tttatatttt cggtactcaa 2291881 tcagcttttc aatcagttcc tcccgcggat cttcttcttc aagtaattca tcttcaaaaa 2291941 gctcctcctc ttgcttcggg agcagcattc tgcttttaat gctgagcagc gtggcagcca 2292001 taaccaaata ctcgctggca atgtcgagct caagcacgcg catcgtatgt acatataata 2292061 aatattgttc agtgatcttc gccacaggta tatcatatat gtcaatttca agacgattga 2292121 ttaaatgaag cagcaggtcc aatgggccct caaacgtatc aattttcact tgatattctt 2292181 ccatcatctc accattttca agtatcactc tcattgccgg aaaaactggc taccctatag 2292241 tataagccac caaaaagctc tcgtccaata ctatttcata tcctgttttg aaggagtttg 2292301 tacagaatat tcaaaacaca agaggtgttt gctcggagcg cagaagcggg agaaaaagcc 2292361 tttgcttctg gttttccttt ctaagaagca ctagaggccg ggcgttcttt tttcctttta 2292421 tcccttctat ggtacactaa aagcacatta aaggaggaag caccttgtat ccgaaagctt 2292481 atatagatta tctcgttgag tttcatgcga cacgggatta ttttgaatgc catgaaatat 2292541 tagaagaata ttggaaggaa gatccgccaa agaaacgaaa acgctattgg gtgggcttta 2292601 ttcagcttgc agtggcttta tatcatcaca gaaggcagaa tacagccggg gcaaaaagac 2292661 tgatggcgaa cagcatccgg attcttcaag cagaacaccg ggcagtcgaa gacttagggc 2292721 ttgatcatgg ccgtttgctc gaacttatgc aatcggttta cgaacaaatc gaaaccgtct 2292781 ctgcctataa aagcattata ctgccaatca aagatgagaa actggaggaa gcatgcagga 2292841 tcgaatgcag gaaaaaaaag tatacatggg ggcagcccag tgcactcagc aacatatttc 2292901 ttatcgacaa acaccgtttg cgggatcgga ctgacgtcat ccgtgaacgt gaaaaagaaa 2292961 tagaacgcag aaaaaaaagc agagactgat cacagcctct gcttaattat tgtatgaaat 2293021 gtcttgatcc tgctgacctt gacaacgttc gaaaaagctc tgcgttaatt catttggaac 2293081 cagtacttgc gttttgaata aatgctttaa agcatccatc atctgttttc cgattccttg 2293141 atggcgatga gaaggattca cactgatatg ccggatctca acctcagaat cctttttttc 2293201 gactccgatt gctccgacga tatcctcgtc ctctttccaa agaaagagct ggcggtctgt 2293261 atccgtttcg tagtccttaa ttgtctgctg aagctgctta aggtcttttt cattcggcat 2293321 aaacgaaaga agccccatcg caatcttttc aaacgatttt ttataacgaa ttaacataaa 2293381 aacccctcta tatccaaaat gtccagtctg ctattaacgg atacgaatag gtgatccgtt 2293441 ttctcacatt atatcatttt cgccatattt ttaaactgtt ttcagcaaat tattcaaatg 2293501 agcggtttaa atttgccatt tcaatggcag aaacagcaca atctacacct ttgttgcccg 2293561 cttttgtgcc ggcacgctcg atagcctgtt cgatgttttc agttgttaca attccaaaga 2293621 tgacaggtac accagtagtg tttgctgctt gcgcgatgcc ttttgcagct tcattgcaga 2293681 cataatcgta atgtgtcgtt gcgcctctga tgacagtgcc caatgtgata atagcatcat 2293741 atttttttgt ttccgccatt tttttcgcag caaacggtat ttcaaatgcg cctggaaccc 2293801 aagccacatc aatgtcattt gtgtctacgc catgtctgag cagcgcatct tctgctccgc 2293861 tcagcagctt gctcgtaata aaatcattaa atcttcctac tacgattccg attttaagac 2293921 ctgtaccaac taaatttcct tgtatgatat tcatatgatt cccatccttt tttgtgatat 2293981 ttgtgattag aaatgaagta aatgacctag cttgttcatt ttggtttgca aatatttttt 2294041 attgtgttct ttcgcctcca tttgaagcgg cactctttct gaaatactga gtccgtagcc 2294101 ttcaaggcct gcgatttttc gcggattatt cgtcaaaagc ttcatattcc ggacaccgag 2294161 gtcgcgtaaa atttgtgctc cgatgccata gttgcgaaga tccggcaaga atccaagcgc 2294221 ctcattggct tctacggtgt catagccttg ttcctgaagc ttataagctt ttaatttatt 2294281 gattaaaccg atgcctcgtc cttcttggcg caagtacagg agcactccac ggccttctgc 2294341 ggcaatttgg ttcagcgcgg cgtgcagctg cggtccgcaa tcacagcgat gagagccaaa 2294401 cacgtcacct gtgagacatt ctgaatgcac ccggaccaat accggttctt ctccgaacgg 2294461 cacatctccc atcacaaatg cgacatgctc ttttccatct acctcatttg tgtatccata 2294521 aaccttaaat gtcccaaaat cagtaggcag cgtaatgtca acttcacgct cgacaagtgt 2294581 tgtcagattg taacggtatt gaatcaaatc cttaatggtg atcattttta attgatgctt 2294641 tttcgcaatt tcaatgagct caggcactct cgccatcgtt ccgtcttcat tcataatttc 2294701 acaaatgacg ccggctcctg gagatccgca agcttcagca agatcaacag cagcttctgt 2294761 atggcccgct cttttcagga cacctccttt tttcgcaatc agtggaaaaa tgtgccccgg 2294821 acgctgaaaa tcagatggca cggatttgct gtccagcaat gcttgaacgg taaaagatct 2294881 ttcttgagcg ctgatacctg tcttcgtttc acgatggtct atgcttacgg taaatgcagt 2294941 gtggtgagag tctgtattat gctcaaccat agggtgaaga tcaagcctgt ctgcgatttc 2295001 ctcactgagc ggcgtgcaga tcagtcctct cccatgtgtc gccataaagt taatgacttc 2295061 cggcgttgca tgctcggcaa gagccacaaa gtctccttca ttttctctgt cttcatcatc 2295121 tacaacgatg atgacttcgc ctttttttaa agcgtccagt gcttcttcta tcggatgaaa 2295181 catgcaaatc ttcctctcta aaagccgttt tcgcttaaga aggcttttgt aatggtttgt 2295241 tgggtcttat tttcattggc tttatgcaaa aatcgataca tatattttcc gatcatatcg 2295301 cattcgatat tcactttaga gccgatcgtt ttttctgaaa agatcgtttc gctgatcgta 2295361 tgcggtatta aggagatcgt cactgtgtct tctgtcaggc cgaatatggt taagctcacg 2295421 ccatccacag taattgatcc ctttaaaacc aatgtttttg ttaatgacgg gtccattttt 2295481 aaatcatagt aaactgcgtt gcttttctct tcaattcgtg tgatttccgc agttccgtcg 2295541 acatggcctg agacgaaatg gcctccgaaa cggccgtttg ccgccatcgc tctttccaga 2295601 tttactttgc ttccttttgt taaatcattc agtgacgtag ctttgactgt ttcaggcata 2295661 acatccactg tgaattgatt ttttgtaaaa tcagtgacag tcagacaaat gccgttcact 2295721 gcaatgctgt cgccaagatg aacatcctct aaaatctttg agcatttaat agttaaggcc 2295781 attgcatgcc ctgctttttt catggattcg attgtgcctg tttcttcgat aattcctgta 2295841 aacatggtca ccatcctatt cctttgtcgg ttttgccgtc agtttgatat cacggccgat 2295901 ttgggttata tcagtgaatt gtaataaggg gacatctttc attgattgaa aaccttcacc 2295961 ggagattaag ctgggagcat gcgttcctcc gattagttta ggggcaaaat agaagatgat 2296021 ttcttgaaaa cagccttctt tgacaaagct tccgtgaaca gctgaaccgc cttccacata 2296081 caccgacatg atgccttctt ccgctaggat cttcaaaaca tcaggaattt gaatgcgctc 2296141 ggtttcaagt gtaaatatgt tcactccgaa agctgaaagc cgttttttct tttcctcgtc 2296201 tgcgcgtgcc gtcgtaaaaa tccatgtcgg cgctatttga tcgcaaatca ctttagcgtc 2296261 ctcaggaatc gagagtacgg tatcaagtat gacccgaacc ggctgttttg ttacattcgg 2296321 cagtctgcag gttaagctcg gattgtcggc tttcactgtg ccaactccga ctaaaatgct 2296381 ttggtgtgtt ttcctgtatt gctgagcatc ctgtcttgca gcctctgacg tgatccattt 2296441 gctgtcaccc gtgctggtag ctatcttgcc gtcaaggctg gcagccgctt ttagcgtgac 2296501 gtacggaagg cctgtcctca taaagtgcag aaatttttca ttcagcctct ccgcctggtc 2296561 tgccaggatg ccttccctta cctcaatgcc agcttctttc atcatgctga tccctcttcc 2296621 agccacaagc ggattaggat ctctcatcgc cacgaacact cttttgatac cagagttgat 2296681 aatcaattct gcacatggcg gtgtttttcc gtaatggctg cacggttcga gtgtaacgta 2296741 aatgtcggca ccctctgcat gtgctccagc catatggatg gcatgaactt ctgcatgagc 2296801 ttcaccatat tttaaatggg cgcccattcc gacaatttgt ccgtccttta cgacaacagc 2296861 gccgacgagc ggattggatt cggtctgtcc ttcgccctgc ttcgcaagat ctaaggccag 2296921 cttcatataa tactcttcca tttgtttccc tcccctcttt tgttatttac cgtcaaaaaa 2296981 gccccgaatt tataaaaaat tcggggcttt aggtatttta cgcaatagga aataacacta 2297041 tgcattttta aacattttgc atagcggctc atcatccttc tcccatccag actttcactg 2297101 tcggcttcag cttaaactga atccaccgcg tgcttatgca cacgggtcac gggctctaaa 2297161 gcaaatgtgc tttactaccg ccggtcggga tttccaccct gccccgaagg atacaatctt 2297221 tattcatttg tccttattgg ttattatagc gatccttttt aaagtacgca atgaaataaa 2297281 cttacaattt gagaaaaaca aaacatcacc cttcgatccg aaaggtgatg ttttttaatc 2297341 attcactttt gcaaccttga ttaatccgtc gatccgcttt gatttgctga agtaagcctt 2297401 aatcttgtca ccttctttta tatcagataa atcctgattt aatttttttc cgttgaagat 2297461 gattttcgtt ccgttttctg ctactccatg atactctgag ccgtcaattt tcgtcacttt 2297521 atattcctgg atggtgtatt cctcttcttc cgaggacaag gtttgtccaa ttgctgtcgg 2297581 aacatccttc agctcaatat catttatgta catataaccg cctgcaagta aaagcaaaag 2297641 cactaacaga atggtaatct tggtttttat tcttcccatt tctaaacctc cagccaatat 2297701 gaatctattc attcatatga gttattcctt tttttcatga ataaaaaacc gtaaattctc 2297761 gtaaattatt aatataacga tgcataacgg gaatatgttt cacatttctg caaaaatttc 2297821 ttttctatag atatacgaat ttatgttctg tttttagggg atgaccgtaa aaaagatata 2297881 aaaaaagcag ccccaatggg aagctgcttg atcctaattt gttttgcgca tttcgttaaa 2297941 cgggtagaaa acaaactttg acgtacccgc aatttgtttt ttcgtgaaga ggccaaggcc 2298001 gttacggctg tccatggaat tgcgacgatt gtcacccatc acaaaatact tgttatcagg 2298061 cactttaacc gggccgaaat catcggtcaa atggtcaaaa ccgtcctgtt tcgctctctt 2298121 tttattagcc gccaaataag gttcgtccac ctttttcccg ttgatataga gctggtcatt 2298181 tttcatctca accgtatcgc cgggaaggcc gataatacgt ttgacatagt gaacatcatc 2298241 tccgtttaac acgacgatgt ctcctctatc aaactcgccg atgtatttga ctgtcatatt 2298301 aacaaaaacc ctttcacggt tgtgaagtgt aggatacata gagtcaccat caacgacata 2298361 cggcgcaaaa ataaagttgc ggatgagcaa agcaagaacg acagcaatca caattgcttt 2298421 tgcccattct aatattgact ttttcttcga aacattttct gatttcaact gatttcctcc 2298481 aataaacaac ggtcttcaat ttatgttatc acgaatcgaa aaaaaatccc attaggacca 2298541 ttgaagtgat tttacaaact gttaatcttc atcttctacc cacatcatgc ctattttttc 2298601 ttgtcgatca taactaggcc tgaaaatatt gaaagaaatg aatcgcataa ttcagaagcg 2298661 atggactcag aagaaagaga gttctcatat gcaaaatctt tagatcgtat ataaagcatg 2298721 aggttacggg cagtttgttc atttactgca ttccattgat ctcccagtcc atgataccca 2298781 tggcacttga caaaacaatt aacgtcatga aggttactgg aatgtttgcg gcaacctatt 2298841 tcacaggtga taaccgcacc ccgttttttg ctttcataat atgtttaaaa tcattcaagc 2298901 tcgaaaacat ggatcagcct ccaaaaaata aatccaatat attcccggca gttgaagact 2298961 ctttattata aaactctgaa tatccgcagt tcttacagta aaccactaga aatcggttat 2299021 gctgcacgtc aaacagcttt gataatcccg tgccggttgt agctatttct ttttgtccgg 2299081 cttcagtact accgcatttt atacagcctt tgttgttcat atcgcgatct ccttttcatt 2299141 acatcacgtt tgtttgattt attttactac aaaatatcaa tcccaatgac ccgtactact 2299201 ttaaagttta cttaattttg attacatact aattgggttc gtttctcagc ttggtaaatc 2299261 ttctggagaa acggaaaagc tccatgacca aaacattcaa actcagccaa acaccgccga 2299321 aggcgtaacc cgcagcaaca tcactcggat actgctcata aagtacacac ggctcagccc 2299381 gatgaggaat aaaacgataa taaacaaaaa aatgcaacag tttgcagacg cgtcttgtga 2299441 gaatgacgaa caaaaagata agcacaaaaa ccaaaaatga caaatgccgt taaagtctgt 2299501 tcgctcggga atggatataa tacatgactt tccaaaggag cgtgaacagg atgaagggaa 2299561 tgaaagagcc gtctgattcc ctcttcataa agctccccac caatgactag gaaaaataag 2299621 aaagagagtt cgattttccg atcttgccct ctgaataccg tccaaaaaaa agttagaaca 2299681 ataacggcta acagaacacc tctcgacgca aaagctttct gaattgcagc tgggcccagt 2299741 ctatacccga tccaatacga catgctcact cccacagctc cccaatccgg ccgctaacat 2299801 gcttagcacc cagtttaact tttcttgaaa cacgagaaca ccggcaaact ctcccggtcc 2299861 aagtaaagct agaagctcta acatcaagac aataaacaag acggcatatc cgtactgttc 2299921 gagcaacccc gtcaaaactt gcatgtgatt ctccttaaac ttttttgttc ttttatcatt 2299981 cccaatccac tttttgtata atcagcacaa ttttatcttc agtcgtccaa caacattgtc 2300041 tatggcggga tcttctctca tacattcttt tttgacatag gaggagcaat agcatgaaat 2300101 gggaggaaac aaaagatacg cagggagttt gccaaaattt tgggcagttc gttctgccac 2300161 cgagtcaggt gtttgtttgc ccacctcatc ccttgtcaat tccccatttt tcccgtttga 2300221 ggttcgaaat ggtaaagtat ttcacttagt ttcttacatg aagaggtaaa ttctttgctc 2300281 accgaactag gatagcggcg tatggcgatt tctacattgc ataaccactg gttatttagt 2300341 gagccgtgag caatgtatat gcactttgag tcagcacagg atgatcctat tacattcgcc 2300401 agaaaagcag ctgccgcatt cagagtagtt aaaagaatag acagatatct gggcttccgg 2300461 aagctttaaa ggaggctctt ttttcgagca tttttataaa tcaataaaaa caggcatctc 2300521 ctaaatattt ttgccgataa gtttacgcta atcaactcta gcactaatac atataaaaaa 2300581 tagaatgata tgaaaggaga cttgatagta tgattgatta tcctattaat ataaacaacg 2300641 tttccgggaa cagtgtaatt aacgtaggcg gcgcttttat gatcaggcct ttaactttgt 2300701 ccaaatctgt gtttggctcc ggaggtttaa acacaggaat tgtctttgaa aataactttg 2300761 taagcaaagc taaaatgatt aatcatcaat ttactgatca aaacgtcacc aaaacttttt 2300821 aatgtattca atacacgggg gtcactaact aaacacctgg ttttgccaac cgccatcagc 2300881 attcggcggt tttttattga acatttttgg ccaataaaaa aagcttcctc tctaagagga 2300941 agccttttgc ctgccgatta gccttctaca cgaacttctt tcatgacatc gccattagac 2301001 atgtttttcg cgaattctaa tccgcttgtt actttaccaa atacagtgtg aacaccgttc 2301061 aaatgaggct gtggctcatg aacgatgaaa aattggctgc cgccagtgtc ttttccggca 2301121 tgtgccatag aaagtgcgcc cgcctcatgt gtatgcgggt tgccttctgt ttcacatttg 2301181 attgtgtatc ccggaccgcc tgtaccagtt ccgtgcgggc atccgccttg gctgacgaag 2301241 ccagggatca ctcggtggaa tgtaagcccg tcataaaagc cttcgttcgc aagcttttca 2301301 aagtttgcaa cagttccagg tgcagcttca ggataaagtt caaattcaat tttgttcccg 2301361 tcttctaata aaaagtaacc tgttttcaat tgtatgccta ctttctttat tttaattttc 2301421 aaaggagatt atgtataggt tatagcctgt ctctccttgt cgcggctatt ataccacacc 2301481 tttcggggga aaacgaatct cccgagcttt actaaaaaat aaaaatgaaa cctgaatctc 2301541 tttatctccg tctaacctaa cggaactgta tttttcatga ttcaggtcct cacaaagcag 2301601 cactatccag ctgcttgtga aattgaagga ggtcaaactg ctttgaagaa aatttggatt 2301661 ggaatgctgg cagcggccgt tttgctgctg atggttccga aggtcagtct cgcggatgcc 2301721 gcagttggag atgtcattgt aacactgggt gctgatttgt cagaatctga caaacaaaaa 2301781 gtgcttgatg aaatgaatgt ccctgataat gccacaacgg taaccgtgac caataaggaa 2301841 gaacatgaat atttaggaaa atatatatcg aacgcgcaaa tcggatcgag agcgatttct 2301901 tcatcgtcaa tcaccattgc caaaaaaggc tccggattga atgttgagac ccataatatc 2301961 agcggcatca cagatgaaat gtacctgaat gcactgatga cagccggtgt taaagatgcg 2302021 aaggtgtatg ttacagcacc gtttgaagta tccgggactg ccgctttaac tggattgatt 2302081 aaggcgtatg aagtttcttc tgacgaagcg atctcggagg atgttaagca ggtcgccaac 2302141 caagagcttg tcacgacatc agagcttgga gacaaaatcg gtaacgaaaa tgcggcagcc 2302201 ctgattgcaa aaatcaaaga agagtttgct aaaaacgggg tgcctgataa taaagctgac 2302261 atcgaaaaac aagtggatga cgcagcttct gatttaaacg tcacacttac agacagccaa 2302321 aagaatcagc ttgtctccct attcaataag atgaaaaacg ctgacattga ctggggacag 2302381 gtcagtgacc agctagataa agcgaaagat aagattacga aattcataga atcagatgaa 2302441 ggcaaaaact tcatccagaa agtcattgat ttcttcgtat ctatctggaa tgcgattgta 2302501 tctatattca aataagaaaa gcgccgaaaa atcggcgctt tcttttattg ctttacaccc 2302561 gttttaaatg gcagatcaag ttttacaata tcttcgtatg tttctcgctt cacgactaaa 2302621 tgagcctcac cgttttcgac aaatacaacg gcgggtctcg gaatacggtt ataattgttg 2302681 gccatgctgt atccataagc gcctgtacaa aaaacggcaa gaagatcgcc ttcttttact 2302741 tccggcaggt caatatccca aatcagcata tctccgcttt cacagcactt tccggcaatt 2302801 gataccgttt tgtcatgcgc ttctccgatc ctgttggctg ccgcagcttc atatttagct 2302861 tggtaaagcg caggacgaat attgtcgttc atgcctccgt ctacagccac atattggcgg 2302921 acacccggca cttctttttg agagccaacc gtataaagag ttgtgcctgc gtctcccacg 2302981 agagaacggc ccggttcgat ccaaatttcc ggaatgtcaa aaccgtaacg ggaagcattt 2303041 tctttcacag cttcgataat tttttcaacg tattcagtgg catgaagcgg ttcatcatct 2303101 tccgtataac gaatgccgaa acctcctcca agattcagca ccttggatac aaatgaatat 2303161 gaatctctcc attcgtctag ttttttgaag attttttccg ctgctaacac aaaaccggcc 2303221 gtatcaaaga tttgcgagcc gatatggcaa tggacaccca gcagctgaat gtgttccgat 2303281 tgtaatactt gttcaatggc ccgttcagtt tgtccgttat gaagatcgaa accaaacttt 2303341 gaatcttcct ggcccgttgt aatgtagtca tgcgtatgcg cttctactcc gggcgtgatc 2303401 cgaagaagaa catcgatgga gtgacccgtt tctttacata ggtcttcaag aagcgcgatt 2303461 tcatagaaat tatccaccac aatgcagccg atgcggtgct caagcgccat ccgcagttct 2303521 tccctgctct tattgtttcc atgaaagtgg atgcgttctg ccggaaagcc tgctgcaaca 2303581 gccgtatata gctctcctcc ggatacgaca tctaaagaaa gtccctcttc ctcagcgagc 2303641 tgaatcattg cgactgatga gaatgctttg ctcgcatatg ccacctgtgc tttcagccct 2303701 gcagaaataa acgcctgctt aaagctttta gcacgctcac gtattaaagc cacatcatat 2303761 acgtaaagag gtgtaccata tttctccgct aaatagagag catccacacc tccgatttct 2303821 aaatgaccat gttgattttg tctgcttgtg ccgtgtaaga acaatgtcat tccctctttc 2303881 tccgcttatg gatgaaagga cagttttatg gactgtccct tcataattaa gacatacatt 2303941 atcatactct tcagtcagtt tcaatgcgat tatgaattgg taggctgcct taagcgattt 2304001 ttggggtgaa cgatgctggg tcttactttt gcgccaggtt tcgctgtgcg gacaagaacc 2304061 tgccacagcg cctttccgtt aaagggaatc agcggccata agtacggtgt ctgaagggat 2304121 ttgatgcttg ccatggcaat aattagcact gtaaatccga tgacgagccc ttttatatga 2304181 aataaagcaa cgagtatcat gaggacaaga cggctcattt tgtttgccaa gcttaattca 2304241 taactaggcg tcgtaaaggt tccaatcgcc gcaagtgaga cgtacagaat cacctcagga 2304301 gaaaaaaggc cgacctcaat cgcaatctgc ccgatcagaa cagcggcaat taaacccatt 2304361 gctgtcgata aagccgtcgg tgtgtgaatg gcagccattc tgagaaactc gattcctaag 2304421 tcagctaaaa atatctgcag gatgatcggg atatgcgtat ctttatttaa accgataaat 2304481 ttcatgttgt ccgggagcag atcaggctga agcacaaaga gaaaccagat cggaagaaat 2304541 aaagtagaag caagaatacc gaaaaatctt acccatctta aaaaggtccc gactgaaggc 2304601 gcctgcctat attcttcagc atgctgcaca tggtgaaata aagtcgtcgg ggtaatgatc 2304661 acactcggcg atgtgtccac tataatgata acatggcctt ctagaacatg atttgcggcc 2304721 acatccggtc tttctgtata gcgcacgagc ggaaaaggat tatagctttg attaacaatg 2304781 aattcctcga cagttttgtc tgccattgtt aatccatcga catcaatgga tgcaatttct 2304841 ttttctacga tctcaaccag atccggatca gctatatctt ctatataaca aatgcttaaa 2304901 tccgtctttg accgctcacc aactttagtc atcttgactc gaaggcgttc gtctctgatc 2304961 cgccttctga gaagggccgt attgacgacg atattttcaa caaatccgtc tctggctccc 2305021 ctgaccacct tttccgtatc aggttcttcc gggtttctgc ccggatagct tctgacatca 2305081 attataaatg cgaagcctgc accttcaaca atgacagcga cgagcccgga cagcacttgg 2305141 tcggtggttt catccaaggt ttttactttt tcgacctggg cgttaagcag cctgttttcg 2305201 acgatgtcga ccagctcatc agggtcttct ttccgattgt taatggcaac aagctctctc 2305261 attaaatgaa taatataggc tgtatcgcat aatccattta gatagtaaag ctggatctct 2305321 ttatctaaaa tcgtgagctt gcgaacacct acatcatagc tcgtccccat cccaacacgg 2305381 tttttgaaat actcttcatt tttagctgga ttccgataaa cccgaatttt ctcttccttg 2305441 tggtccggca tgatacccgc tcctttctaa aataaactcg accgctttca tggtgattgg 2305501 cgaccctttt gagatatcgt cttttctgcc cattttgccg atatccccga taccgacaat 2305561 aagcgggaga tcaagtttat caaggcaata gactgtatct ccactcattc tgtggtcatc 2305621 aaattccctt tccccgactt tatcgacgcc gtattcagtt atttctccat tgcggtcaat 2305681 gcttacatcg accctggtcc attcagcctg atgtgttttt gacgcgaccg caatcacacc 2305741 gagcacttca atagacggat gggttgcgac ataggttaga gcggcttctc ccgggccctc 2305801 tccttgaagg ccggagtcgt caaacatgac aaatacagga tcatacggtg ctgaggcgat 2305861 cagcttgaca agctcggcgc cgctgcgggt ggaaggattc ccttttgatt gtgaaataca 2305921 tcggcctccc actttgcttg cggcgtattc aattgtttta gcggcataaa catccccgtc 2305981 tgttaccagt atgaccttgc gttttgtcgt catgtcggca ttatcctttc ggtttgaaaa 2306041 taacagctac gataaaggcg aaaagaatag cggctgagat accggccgag gtcagctcaa 2306101 aaatccccat gccgattccg ataaatccgt gtatatgcgc ctgatgcatg gcgccgtgca 2306161 gaagactgtg accgaagctg acgatcggaa cggtggcgcc tcctccggca aattcaataa 2306221 atttatcgta aatgccgaaa ccatctaata ttgcaccgat tacaacaaat gatgtcatga 2306281 catgagctgg cgtcaattta aaaatatcca agagcagctg gccgacgata cagatggccc 2306341 cgccgcagac aaaagccaaa aggtagtcca tattaagatg cacctcctgc acgctcaaat 2306401 acaaccccgt gggcgatagt cgggatggtt tctttttgct ggatcatcgt cgggcttaat 2306461 agcgccccgg tcgccacgac aaatacacgg tttagttttc cttctctcag ctgcttaaaa 2306521 atatgagagt aggtgacaac cgctgaacaa gcacagccgc tccccccggc aaagacctgc 2306581 tgatccggag tgtaaatcag aagcccgcaa tcatcatgct ttgtgccgac tggatatcca 2306641 tcttctttta aaatgtcttt tacgattgga gaaccgacgc ctgacaggtc acctgtcagg 2306701 attagatcat agtcatccgc tgtccggttg agatctttaa agtgctgctt aatcgtatca 2306761 gctgcagccg gagccatagc cgatcccata tcaaaaggat ctgtaattcc taaatcagaa 2306821 accttcccga cagtcgcact tgtgatttgg atatcacccg gtgtctgact gatgacaact 2306881 gcaccgcttc cggttacagt ggaggtagca gtgtccggtt tttggcctcc gtattctgtc 2306941 ggatagcgaa actgtctttc cgcagttgca ttgtgactgc tggtggcagc gagtgccctt 2307001 ttggcaaacc ctccatcaac taaggctgat gcgacagcca ctgtttccat tgatgttgaa 2307061 caggcgccaa acatacaaag aaatgggatt ttcaagtgtc ttgccacata gttagccgtc 2307121 acgttttggt tcagcaagtc gcctgccagc aataggtcaa tatcatcttt tgtcagattg 2307181 tttttttgaa gtgcaacatt aacagcgtct tccatcagct gccgttccgc catttcccag 2307241 cttttttgat tacaatgcat ttcgtcatag gttttatcaa ataaagagcc aagcggtccg 2307301 tctttttcct ttggtcctgc tgccgttccc gctgagttga caaatatggg atgttcaaat 2307361 acccaggttt gctttcctgt taatttcatt ttcttctcct cctatgacat cagtttctca 2307421 aaagcaaacc gaatcattcc aacgatgtat gcagctacaa ctccgaaaac aataacattt 2307481 cctgccagtt taaacatatt tgtcgctact ccaagcacta atccttcgct tttatattca 2307541 agagccgcac ttgccatact gttggcaaaa cccgtgacag gtacggctga acctgcgcct 2307601 gcgaattgtc cgattctgtc atagattcca aaccctgtaa gcagggcaga aattaatatc 2307661 agcgttgcag ctgttggatt ccccgcagtt ttttcattga aatcaaaaaa atggatataa 2307721 aaattttgca gaccttgccc gattgcacaa atcagtccgc ccactaaaaa ggcttttaca 2307781 cagttccaga cgtaaggcgg cttaggctga tatgttttca cttttgattt gtaattttct 2307841 tttatgtttg tcatcttgaa acctccttat gaatggtcaa taaagtacag ccagtgaaat 2307901 aaagatcccg cgattttccc aatcacgatg gccattaaca gaataatgat tttacttctg 2307961 agcccgattc gtttcgccaa aatcggcagg acatttaaaa cctctgtaag agcagccgct 2308021 agcatcccga cgaacaaacc tgccagaagc ccgaccggca cagctatcca ttttgttaga 2308081 taaagatgat tcatatgaag cgtctcccat cccccgcaaa ccgcgccaag aataacagcc 2308141 gcttcataag cctgaacaaa tctcattgtt ttggtgagct gcatcagccg cggaatgatt 2308201 cccattacgg ttaaaaaagc aacgaaaccc gcccccaccg ttatgcctcc gccgagcccg 2308261 acaaaaatga tgaacaatac actaacgatc atgcagatcc tttatggttt cttgattctc 2308321 atgcatggcc acatattgat cgagatcaag ctgatagtta aacatctcaa cctccagcgg 2308381 gctgggctct tcatttaggc gctttttaaa tatgtggtta aaaaacacga tcatccccag 2308441 tcccaaaccg atgctgtatg ggatttgaag caaatatgga tagtcattcc tctctccggt 2308501 tatgatttca tatagtgcga tatgaacatc tctcatgctt acatcctcat gaaagttcat 2308561 gatggcaaga cacgatccaa taaacagaag cagccagaca ccgataaata gaaccgttga 2308621 taaatttcgc tttcgatact gaatttcaac aatggtttct gctccgccta cggtttgaac 2308681 atcaattgtc gggtcttgta aatgaatggc tctgaggact tgtatgatat ccagaattac 2308741 gatattttta tctttttcgc tcacctgata aagcggcata gccgaaagtt tctttttcag 2308801 ctgaagctgc ccttctattt gcgcggcatc tccaacggta ataatatccc ctggatgtgc 2308861 cagcactcgg tggcgaagcc ggataaatat tcgtcgttcc atcattgatc accatctttc 2308921 ggtggttata tatgtagtat gtggttcgat tttgttctca ttcatccgct cgaaaagacc 2308981 ataaattacc acgcttttgc acaaaaaagc tagcctgcac tgcagactag ccatccgtat 2309041 gatccatttg aaccttgatc tgttttaata ttttcttttc aagcctggaa acctgcacct 2309101 gagagatccc gagccgctca gccacctcgg actgtgtctg gtctttataa tatctgagat 2309161 agacgattag tttttccctt tcctccaaat cgctgatcgc ttctttcagc gcaattttgt 2309221 caaaccattt ttcttctgag ttgtcagcga tttgatcaag cagggtaatc ggatctccgt 2309281 cattttcata aacggtttcg tgaatcgaag atggagccct taccgcctct tgggccagta 2309341 caacatcctc agcttcaatc tccaaatggt cagcgatctc ctgcaccgtc ggcactctgc 2309401 ccagtgtttt cgaaagctca tccttcgcgc gccggatttt gtttccaagc tcttttaatg 2309461 accgtgatac ctttacggtt ccgtcatcac ggataaatcg ttggatttct ccgataatca 2309521 tcggcactgc atacgttgaa aaacgcacat cataggttaa atcaaatttg tcaacagatt 2309581 ttaacagccc gatgcagccg atctggaaga gatcgtcagg ctcatatcct ctgtttaaaa 2309641 accgctgtac gacagaccaa acaagacgca tgtttttttc tatgaggagg tctcttgcct 2309701 gctggtcgcc attttggctt tgtttgatta attcctttac ttcatgatcc ttcagctgag 2309761 cgtttttgcc gtttttctta acctccacat ccataacaaa tctccttaat tacaaagcgc 2309821 tttgcttttt gataagtgct ttgttaagcg aatcgttgtt cccatttcag gcgatgaatc 2309881 gatactgaca tcatccatga aattttccat aatggtaaag cccattccag agcgctcaag 2309941 ctcaggctta gtcgtaaata gaggctgacg ggcttcttca agatctgtaa tgcctaagcc 2310001 ttcatcacga atagtcatat atacgacatg atcttccagc gtcactgaaa tgtaaacttt 2310061 cccttcacag ttctcttcat atccatggat aatcgcattc gtgacagcct ctgacacgac 2310121 tgttttgatt tcagtcagtt catccattgt cgggtccagc tgagctataa atgaagcaac 2310181 tgtcacacgg gcgaacgatt cattctgact gagggcagaa aactcaaggt gcatttcatt 2310241 tttcatgatg ccacccccag tgtcaggagt gcctgctgtt cagattgttc aaatcggata 2310301 attttaaaca gacccgacat atcaaacaat cgcttcaccg caggagagat agcgcaaaca 2310361 accatttctc cgccaatttg cttaatttgc ttgtatcttc ctaaaataac gccaagcccc 2310421 gagctgtcca taaaggaaag gtcctccaag ttcagcacga tatggcgaat atcatccttc 2310481 tccaatgatt gagtcacttt ttgcttcagg gtttcagccg tatggtgatc gagttcgcct 2310541 gttaatcgaa tacaaagcac agattctttg acattcatgt caattccaag gctcatgctc 2310601 attcctcctt gatatgatcg gataatgagt gtttcgattt cgacggaatg aattccttca 2310661 ccgtgacaaa actagtggtc attcggcata attacttaaa ttttgtccag tctcccatcg 2310721 tccgctttaa gaatgtgata aacccggctt tcttcatatc ttcttttgca gcaacaggac 2310781 tttcagcgag tacttctcca tcctttttca gaacaagagt gccaagctct tggccttttt 2310841 gaatcggagc actaatattg tccttcatct tgatttcttt tttcacatcg ttcatatcct 2310901 cgcctttttt cgtcaatatt gaaatcggct cagatgtagt gagttcgata aatttttgtt 2310961 tccctttttt gacctttact tttgctactg tttgatttcg tttatataaa ggatgcgttt 2311021 catattggct aaaggcgaag tcaagcattt ttgtcacttg cgcgtttctt tctttaggcg 2311081 tgctcgctcc gaatacaacc gctatggccc gcatgtttcc ttttttagcc gaagcagtca 2311141 gacaatattt cgcttcgcct gtatagcctg tttttacgcc gtctacacca ggataaaatt 2311201 tgataaggcg atttgtattt acaagccaaa actttttatc tgtattttca cgcagataat 2311261 cttcatacgt gccggtaaac ttcgtaattg attcgtattt caataattcc ttagccatga 2311321 ttgccatgtc ataagcagag ctgtagtgtc cttcctcggt cagtcctgtt gggtttttaa 2311381 aggatgtatt tttcaatccc agctcttttg cttttttatt cattttcttc acaaattctt 2311441 cttcagagcc ggaaataaat tcagccatgg cgacggaagc gtcatttccc gaagcgattg 2311501 cgatgccttt cagcatttct ttgacagtca tttcttcgcc gggctcaagg aatatctgtg 2311561 agccgcccat tgacgccgca tgctcgcttg tacggacctt atcactcatt ttgattttgc 2311621 ctttatctaa agcttccata atcaaaagca tcgtcataat tttcgtcatg cttgcaggcg 2311681 ccagtctctc attgctgttc ttgttgtaaa gcacttttcc cgtgtcacgt tctatcagca 2311741 ccgcagactt cgcttcatga gcaagctccg atgtacgttt tccgtcttgt tttgcaaatg 2311801 cagacggtgc aaatgtaagc agcattatac caatcaacaa agtggataaa agacgtttca 2311861 tctcaaaagc cctccatttc ataatccttt ttattttttc caagcgtgat ggttttatac 2311921 gccactgatg gaaaatgttt cgaattttgg gcataaaaaa agacagctgt gtgatatcag 2311981 acacagctgt cttttggtcc tgcattgatt catatttatt cgtactgagc gacgatcgct 2312041 ttaacaagct ttaagaatcc agcttttact ttttcggtca cttccataac ttcatcgtga 2312101 cttaaaggct gatccagaat tccggctgcc gcgttagaga tgcaggaaat gccaagaacc 2312161 cgcattcccg catgattcgc tacaatgact tccggaacag tagacatgcc gactgcatca 2312221 gagcccatcg ttcttaagaa acggacttct gccggtgttt cgtaagaagg tcctgtcaca 2312281 gcagtgtaca cgcctttttg aattgggata ttaaggtctt tcgcaatctt ttcagccagg 2312341 ctggacagat ctttgtcata ggctgaagac atatctggaa atctggcgcc gaaatctgct 2312401 tcgtttggcc cgattaacgg gtttgttccc ataaagttga tatgatcggt aataatcatt 2312461 aaatctcccg cacggaattc agtgttgaca ccgcctgcgg catttgtcac gatcaacgct 2312521 tccacaccga gcgctttcat cacgcgtaca gggaatgtga ctttctccat tgagtagcct 2312581 tcataaaaat gaaagcggcc ctgcattgca atgacggaaa ctccttcaag agtgccaagc 2312641 acaagctgtc cggcatgccc ttcaacagta gataccggga attcaggtat atcttcatat 2312701 ttcagcttga ccggattttc gatttcgtcc gccaaaatgc caagacctga gcctaaaata 2312761 aggccgatct ttggagattc cggcaggttt tgtttaataa aagcggctgc gcgttcaatt 2312821 ctgtccttca agaaacagtc cccctattgt aataaagata aaaagctttt cccgtatttc 2312881 ggtttatttg tttggaaatt atcagcgatc gttgcgccaa tatcggcaaa tgtatctgca 2312941 agcggcagca tttgcgcttt cttatgtttt ttgctgtaag cgagaatcgg cacatactcg 2313001 cgtgtatggt cagtcccatg atgaatcgga tcattgccgt ggtcggctgt aataattaac 2313061 agatcgtctt ctctcatttt ttcaaacact tccggaagcc gcgcatcaaa ttcttcaagc 2313121 gcgcgtccgt agccttcagg gtcacggcgg tgtccgaata acgcgtcaaa atcaacaagg 2313181 ttcgcaaagc tcagacccgt aaaatcttct cccagcgtat cgatcacctt gtccattccg 2313241 tccatattag aaaccgttct gcgtgaagaa gtaatgcctt ctccgtcgta aatatcagag 2313301 attttaccga ttgaaatcac atctaagccg cagtctttca attcattcat gacagtgcgg 2313361 tcaaacggct tcagcgcata atcatggcgg tttggcgtcc gtttgaattg acccggctct 2313421 ccgacgaacg gccgtgcaat aatgcggcca accatatatt tcggatcaag cgtcagctct 2313481 ctcgccgttt cgcaaatgcg atacagctcc tcaagcggca caacctcttc gtgagcggca 2313541 atttgcagaa cagagtcagc agacgtgtaa acaattaaag cccctgtctc catgtgctcc 2313601 tggccaagct catccaaaat cgctgtgccg gaagccggct tgtttccaat aattttgcgg 2313661 ccagatctct tttccagctc ttgaagcaat tcatcaggaa agccttccgg gaacacttta 2313721 aacggtttat caatgtataa acccataatc tcccaatggc cggtcatcgt atctttgccg 2313781 tttgacgctt cttgcatttt tccataatag gcaagcggat gttctgtttt ttctacacct 2313841 ttgatatctt cgataagacc aaggccgagc tttgccatat tcggcatatg taatccgttc 2313901 atatgctcgg caatatgacc gagcgtatga gcgccttcgt cattaaagtc agcggcatcc 2313961 ggcgcttcgc cgattccgac tgagtccatc acaattaaaa acacacgatt atatttgtat 2314021 gcaggcatct tgaaagcctc ctttttttct atacgtctat tgtatcgcta agaggtctga 2314081 caactcaagt ataaaccgtt ttcattcccg ttgacaatgt atttggaaat aatgagaaac 2314141 ttcaatattt tctgtcgctc taaacaaaaa agccgcagcc acctgcggct atgctcgcgg 2314201 atgaaactgc ttgtacacat ccttcagcct tgttttcgtc acatgcgtat aaatttgcgt 2314261 cgtggatata tccgcatgac cgagcatttc ctgcaccgct cttaaatctg ccccgttctc 2314321 aagcagatgc gtcgcaaagg aatgcctgag tgtatgcgga gtcagctctt tcttaatgcc 2314381 ggcttccaat gcgatttttt tcaggttctt ccaaaatccc tggcggctga tctgtttgcc 2314441 gtgatgattt aaaaagaggg cgtcagatac attatttttt aacagttttc ccctggcttt 2314501 tgtcatatat tcctcaatgg cggaagcagc ggcttcaccg attggcacaa tccgttcttt 2314561 tcttcctttg ccgaagcatc ggataaaccc catagataaa tgaacatcag ccgttttcaa 2314621 ttcaatcatt tcactgactc gtatgcctgt cgcataaagc agctccagca ttgctttatc 2314681 ccgatatccg aaagggctcg tcagcttagg cgtgtccaat aaccgctcga cttcattgag 2314741 cgcgagcacc ttcggaagcg cccgttccgt cttttgtgtt tcgatatgaa cggaagggtc 2314801 cttatccgtt actttttccc tgagcagaaa ttgatgaaaa gagcgaatgg atgccaaatg 2314861 ccgcgccgat gtcttgccgg atttccccga gtccttcaaa tgctttaagt attggataat 2314921 atgtatgcgg gtaacgtgat tccaatctgt aacatgaagg gtttctgtta agtagagaga 2314981 atagcttttc aagtcacgtt cataggatac gatcgtattt tgagagagcc ctctctctac 2315041 cataacgtag tggatgaaat cctttatttg atctttcact cttgatctac tccccgtttt 2315101 ggtaaaaaaa gatcaaccgg tcgaaccatc cgcctttttc atcctgatcc atttcaacaa 2315161 cttttacagc ggagccttcc ggtttatcat accgatgata gttttcatac tcttgattca 2315221 cccatatcat agcataatag aacaaagcgg taaaaccggt aaacaggatg aaaactttca 2315281 atgcatcgac agctgttttc aggaatcttc ccatgtccta atcgatcctt tccctatggt 2315341 tccagttata taaaccatat gccaaatcag aaaggtttta tacatagaaa cagcaaaaaa 2315401 ccctttcccc atgagaaaag gttcgcgctc ggcaccgtct attcagtttc ttttccgtta 2315461 cagcggtggc aaatgccgtg aaacgtcaat ctatgatctt taatcttaaa tttccaatca 2315521 cgttcaatga tttcttccac gtcttcaagc aaatcttctt caatttcatc aacggctccg 2315581 cactccatgc acaccaagtg gtgatgaaag tgagctgcgc cctctttccg aaggtcgtaa 2315641 cgggacacac cgtctccaaa gttaatttta tctacgactt ttaattcagt taataattca 2315701 agcgtacggt atactgtagc gagaccgatc tcaggagatt tctcttttac gaggaggtat 2315761 acatcttctg cgcttaaatg gtcttcttcg ttttcaagca gcactcttac tgtcgcttca 2315821 cgctgtggcg taagtttata gctggatgag tgcagttgtt tcttaatacg atcaatacgg 2315881 ttttccatgt ctttccctcc tacgccgcat tccatgactc attataacaa aatacgcgca 2315941 gagttccaac tataattatt ataaactgat aaataaaatg gttttctttt aataatgatt 2316001 ttaaaaaagt ctagatgtaa gcttttccat taaaacagga gataagtatg cttcaaagag 2316061 agatgaaatc agcgctaaaa acagaatgac cagcagcaca aaggcatacc gcccgaacca 2316121 ttgaatcggc gcgtcatgca ggcttcgttt cacgaacagc tgtctgatta actttaaaga 2316181 aaacgcaatt gcacatgtgc ccataatgag ataagccgga atcagcagca cattttgcgg 2316241 caaaacggag acaaatgata ggaaaaaccc gcttactccc atctgattga ctaggaaccc 2316301 gacagtaaag ccgacgacga tccctttcag aaagatcata atgaaaataa tcggcatccc 2316361 aatgacggaa attcccagta tccacatcag gcctaaatac tttgcattat gaaagatact 2316421 ttgcccaaac atatcagctg aacttgcctg ttttccatcc gaaagctgtc caaaaaattg 2316481 acttaagtag tagtataaat cttctttctg gctgatggtc atactgttga caataatcgc 2316541 gccaaagatg acacccatga aaaacagcac tgacacaaat atataaagag agagatgatc 2316601 tttgacatgc ctgagaaaca tgtccttata agagattttt cgcataccgt ttcctcccgc 2316661 ccgctctagt gatttgattt aatagattgt atgaaagaaa cagaaaaaca tgcccttttt 2316721 caaaaagaaa caatagagat gaatgctagg cggctttttg gggcacaaaa aaatccttat 2316781 catcaactgc tgtatgatca taaggattct tatgcttccg tttattcaaa atctcttttt 2316841 tgctttttgt cattcttcca tgtgtgctga aagatggtgt gctgcctctt gataataaga 2316901 cgtcacgtcc gccgtttctc aatcgatgcc cccgcttctt tttcgcttgg ctttttgcca 2316961 tgtgatcact ccctttttta ttttcatagt aatgataaca aaattgaaca atgataagaa 2317021 aaaaacagca cctgctacga caggtgctgt ttagctacat ttatttcact gctgtaagag 2317081 ctgcatgctc gacagctgct gctaccgcat gatggacttt tgaatcaagc ggctgaggga 2317141 caacatcacc ttgtttagtg caagctgcga tggcctctgc tgctgcgaca agcatatcat 2317201 gattaatctc cgtgcttttt gcgttaagcg ctcctctaaa aatccctgga aaaccgagta 2317261 cattattaac agaacgcccg tcagctgcat atgcggcgcc agcctgcagt gcggcctccg 2317321 gctcaatttc cggcttcgga ttcgataaag ccagaatcac ttgaccagaa cgtacaaatg 2317381 ccggttttat taaacccgga acgcccgttg tagcaatgac aatatcacat gtttccataa 2317441 gctcctcaat actggaaact gcctgtccgc cgtattgttc gagacggttc attgctgact 2317501 ctgatttgtc tgttccgtat acagcattca caccataagc catgaacatc cggcagatgg 2317561 ccacgcctgc tgcgccaagg ccgatttgcc ccactttcgc ttccttcagg tcaacccccg 2317621 cactcctgca tgccgaaatg gcagctgcca gcgtcactac agctgtacca tgctggtcat 2317681 cgtgcataac agggatgttc agctcctctt ttaggcgatc ctcgatttca aaacaatgcg 2317741 gcgaaccgat atcctcaaga aggatgccgc taaagcccgg agaaatatgt tttactgttt 2317801 tgatgatttc ttcaggatca ctcgtatcaa gcagtatcgg aatgccgcta atacccgcca 2317861 gctgatcaaa taaagcagcc tttccttcca tgacaggcat gccagccaca gagccgatat 2317921 tcccaaggcc taaaattgcg gttccatccg ttacaattgc aacagaattg ctgatcgttg 2317981 tataaataga agctttttca ggttcttttt cgatcagtcg gcacacgtcc gcaacacctg 2318041 gtgtgtagac acgtcccagc tctgccagtg aacggatcgg cattttgctt ttcatttgga 2318101 tttttccgcc ttcatgtgcg gacaggactt catcagatac ggtgtgaagc ctgatccctt 2318161 ctccgagggc ctgtacagcc gcgatcactt cctgaagctg ttcttcattc tccacttgaa 2318221 cggtaatatt ccgcattgtg taattgggtc cgacttttac cgtctccact tcaccaatat 2318281 ccccgcccag aaggccgatg gccgtagcca cccttccaag atttccggga accgaaggcg 2318341 tttcgatcat cagtgtccga atcatgtgtt tcgctatcat tcagtgatcc tcccctatta 2318401 gcctagtttt tcggctttaa ctgtattgtt tttcgtatac catataaatt ttcctgtata 2318461 accatagata attgcaagac ctattgctac aaaactgagc cacataaacg gcagataaga 2318521 gaaggtagaa acacctaaaa taccagccat gtaaatccca ttatcagacc aaggaaccat 2318581 ccccgaagtc aatgttcccc cgacctctga gttacgtgat aacactcttc tgtccagatg 2318641 taagcgatca tagctgtctt ccataatttt cggagtcaaa ataagagata catacatcgc 2318701 acagccgaag atgtttgcta aaaacgctac gatcagtgta gacaatgtga cattgccggc 2318761 tgaagttaat ttcttttcaa acgttgaaac aatgactttt aacacgccga gtttctcaag 2318821 cagaccgcca aaaccaaggc caaagatgat gacgacgaga gaatcaagca taccgacaat 2318881 tccaccgcgg tttaacaagc cgttcaaaaa ttcaacatcc gttttaatag agaagccgtt 2318941 gtacgcagtt gcaatcgcat gggcaatatc cattccttgg aaaacaacag cccagattgc 2319001 accgagtaaa gcgccaatta cgataactgg catagatggc tttttcatcg ccaataagac 2319061 tatgacgaga actgccggga tcagcatcca aatatgaatg tcaaacgtgt tttgcaaaga 2319121 tgattttaag aattcaactt tatcaagatc aatatttttc ccgccgtaca taaatccaac 2319181 aactgtaaag agtatagctg taatgacata agcaggtatt gataaataaa gcattgctct 2319241 cacgtgagcc aatacatcga cttttgatag tgaagaagct agaactgtac tgtcagacag 2319301 cggagacagc ttgtccccaa aataagcacc tgaaagaata gctcccgcta ctagaggaag 2319361 cggaatgcct aacccctctc caattgcgat catggcaatg ccggcagttc cgactgttcc 2319421 ccatgacgtt cctgttgcca cagacataat ggaacaaata attaacgttg ccagtaaaaa 2319481 gatacttggg tgaataaatt ccagtccgta ataaatcaaa gtcggcacaa cgcctccggc 2319541 aatccatgtt ccgatgagcg ccccaactga aacgagaatc agtacggctt caaggccatt 2319601 tgatatccca tgtacaatcg cattttgtaa atctttataa gaataaccga gtctaatacc 2319661 taaaagcatt gcaataaacc atgaaacaaa aagcgccagc tgtatcggca agtcgagaaa 2319721 gactgtaaac gatagaacaa gtgctaaaaa tactcctagt acaataataa tttcaaatag 2319781 tgttggcaat cttacatcct tcaaaagaag tcccccttca tgtaaaagct aaaacgcttt 2319841 caatatatag tgcaacacgt atactatact tcctcatccc tatgttgtaa acagcttatt 2319901 catccgacta ttcggagatg aataagctgt attttataca aattttattt ttctaatagt 2319961 tctttccctg cgatacctgg tttggtcatc tcatatgggt ttaaaataat atccaattct 2320021 tcttcagtca gcacatcatg ctgcagacaa agatcccgga cagattgccc tgtcataatt 2320081 gcttccctgg caattctagc tgccgcttca tacccaagat gcggattgac agctgtgatc 2320141 acgcctgcgc ttttttctac gtattgcttc atacgctttt cgttggcttc aatgcctttt 2320201 aagcagttgt cagtgaacga acggaagccg ttgttcatga tgctgatgga ttgaagcaaa 2320261 ttaaagacaa gcacgggctc catgacgttc aactcaagct ggccggcttc tgaagcaagg 2320321 cagattgtat tgtcatttcc gataacctgg aacgcaattt ggttgatcag ctccgccata 2320381 accggattga ctttccccgg cataatagat gaacccggct gacgtgcagg cagagaaatt 2320441 tccgcaagtc cggcgcgcgg tcccgacgcc attaagcgca ggtcgtttgc gatcttcgac 2320501 atgttcatca tgcagacttt taatgaagct gatacctctg tataggcatc tgtattttgt 2320561 gtcgcatcaa caagatgatc agcgccgaca agaggaagcc cgctaatatc agcaaggtgc 2320621 tttactacct gtttgatata ttcaggatca gcgttcagcc ctgtaccaac agcagttgcg 2320681 cccatgttga cttcatacag gtgctggcgc gattgcttga ttcgtttgat atcacgctcg 2320741 agaacacggc tgtaagcttc gaattcctgg ccaagacgga tcggaaccgc atcttgaagg 2320801 tgtgtccggc ccattttaat aacagagtca aactcctgtg ctttttgctt aaacacacta 2320861 tgcatatctt ccattgtttt cagcagtttt tctaagagct tcaatgtgga aatatggata 2320921 gcagtcggga acacatcgtt cgtagactgt gacatgttca catgtgtgtt tggacttaaa 2320981 tggatataat ctcccttttt atgtcccatg atttcaagcg cccggtttcc gataacctca 2321041 ttcgcgttca tgttcataga agttccggca ccgccctgaa tcggatcgac gataaactga 2321101 tcgtgccact tgccttccag aatctcgtca gcggcttgta cgatagcttg gccaattcct 2321161 tcatacagcc gtttcacgtc catgttggca agagccgcag cttttttcac aatcgccagt 2321221 gcgttaatca tttcctcatg gattttgtat cctgtgatcg gaaaattttc agaagcacgg 2321281 agcgtctgaa ttccgtaata aacatctgct tcaatttgtt tttccccaag gaagtctttt 2321341 tccacgcgat attctttttg gccgtttaac ataatcttta accttctttc tctttgctgg 2321401 ttatcgtttt tacattttac aggacaacgt catcagctat cggcgtttcc ataattctct 2321461 tgacgacagg aagatccgaa gactgaccta gcgcccacat caattttggc acaattgctt 2321521 ctgtgttcat atttcttgat cggataatta agtcttggtt gactctgcgg ccaacctcgt 2321581 aaatgctcat gtcttcgcct tcttcaagac attgagtcgt aatgacgacg acaatgccgc 2321641 tttcgatcag ttcattcact tttgacaaaa tgtctctgcc ttcaaacggc actcctccgc 2321701 tgccataact ctcaatgaca attcctttgt acatgctttt cagggcatca aacatttcgg 2321761 gctttaagcc tggatgcagc ttcagcagac atacatctgt gcatagtgaa gtgtcaactg 2321821 tgaaggtgtc gttctcaggt tccgttactt gtttgttgta ttcgatcccg tcttcattga 2321881 taaaagcgat atatgggtaa ttgatgcttt caaatgcgtc gtagcttttc gttcttaatt 2321941 tgatcgcacg cgttccctga atgactctgc cgtcaaacac aacataaacg ccgcccacgc 2322001 cttcacaggc aaatcgaatg gcatctgtaa tatttttttt ggcatcggtt ttttggaacg 2322061 tgatcggaat ctgcgagccg gtgatgacaa tcggcttttt ggcatgctgc agcatatacg 2322121 atagtgcggc agatgtatag gccattgtat ctgtaccgtg agtaataaca aacccgtcat 2322181 aggcatcata attttcctta acggcttctg ctatttccac ccagtattca ggctgcatat 2322241 tggtgctgtc tatattcata agcgactgag tttccattgt gtaatcgtta tcaagttttg 2322301 atacgtaact taataattca tcagccttga ctccgggagc cagcccattt tccccttcaa 2322361 ctgaagcaat cgttccccca gttgtcaaca tcaataattt tttcatacca tgcacctctt 2322421 cactgtatct aaagatgggt tgcgagaagg tattcgcttt tcgcatactt ttaatgcaat 2322481 tatagacacg gaaaataaaa tacgcaagac attattattc aattcgcgta cacttcctaa 2322541 tacctatatg atataatcag ctcaaggtga aaaaggagcg gaagttcatg aatctagatc 2322601 gtttaactga attgagaaaa aagaaaaatt ggtcgcttca atatacagct gaccttctcg 2322661 gtatcgcaaa aagcacatat gccggctacg agtcaggcta ccgacggcct tcacttgaag 2322721 cgcttgccat gctggctgac ctctttgaca caacctgcga tgaactttta ggccgcgaga 2322781 aacaaaagca gactgctcct caggccatag aattggccac gtggagcagc ctcgacttta 2322841 ccatttctgt tgatggccag ccgctgagtg aagatgaaat catccagctg attaccttta 2322901 tacgcacaaa aagaaaagta caggaggaac tgagttaatc tttagctcac ggtttaattt 2322961 taccgtaggt tcctcctcct ccggctttca attccagttt tccggatctc gcttttacga 2323021 taagcgccgc ggttttcggc gggacaacgc gagccaaatc ttcttctgca gcctcatgaa 2323081 gaacagccat ttctgttccg aaggcttttt ttagtttgtc cagcgttttc gggcctacac 2323141 ccggaacaaa ttgcagcggg atctgatgta catatcgcgg acgcgggacg cgaacttcaa 2323201 gctgatcact caattcacgc aatctatcgc tgactccctt ggtaaatctg gcttttccgc 2323261 aattcgcgca cgctgtttcc ccgcttacag caggctctcc gcacgcttcg caagccgtct 2323321 gataatattt ccccaataac gggtccaagc cataatttgc gataattttc ctgtcatctt 2323381 gtccctttaa tgcaagagca aattcagtaa aatcagctga ctgcacatat aattcattat 2323441 attctctgcc gattttcccc aacgaatgcg catcagaatt tgttaaaaaa ggatacggat 2323501 tcaattgcga tacgtgtgat gccatgtctg tatcacagct taatccaagc tccaccgcgt 2323561 ctatcataga tggatcaaaa acctcagtta agcttgattt aacccctttt ccatataagc 2323621 ttttatgcgg cgtaaagata tgggcgggga taaacaggcc gcccatatcc tgcacttttt 2323681 tttgcaggtt taagcccgtt tcataaatcc gctgcgagct taaatgaata tttttcagcc 2323741 gggctgacag ccagtttgaa aactgtttca tatcagccag cgtcggcata aatacgagca 2323801 catggatcgg tccgctgcag gcttcatcat aaatctccag ctcgctcccc aataaaagag 2323861 tcgtgctgcg ataacggatt cctcccccgt caagctcgcg atattttcca gatgaaatgc 2323921 cttcctcaag ctctagaatg acttccggag aatgacagtc gataatgccg aggagttcaa 2323981 ttcctttatg ttcactggct tcaaccaaaa ttctgtccag cgttaatgtt ttggcgcctg 2324041 ttattttgac agcccttcct gtaaaggtcc ggccgatatg aatgtgcaaa tccgcgtaaa 2324101 tctttttcat ttttgtgctt ggagcgcttc tttcagctga agatactgaa tcgcgtaggc 2324161 tgttttagca tcatatactt cacgcgattc aaccagcttt agcgcatctt caagcgtcac 2324221 ctccatcact tcaacaaact cgtcctcatc aagctcccgt ttttcttcaa gcacagaaag 2324281 ctcctcagca agaaaaacgt gaacgatttc atctgcaaat ccgggtgatg tataaaacgc 2324341 agttattttt gtcagttttt ttgctgtata accggtttcc tcttcaagtt cccgaagtgc 2324401 cgtatactcc ggctcctcac ctttttcaag cttaccggcc ggaatttcaa cgatcgtccg 2324461 ctcaagcggc ttacggaatt gtttgaccat gatgattttc ccttcatctg tgacggctag 2324521 taccgctaca gctccagggt gtttcacaat ttcacgttta ctggctttgc cgtttggcag 2324581 ctctacatcc tcgacataaa gatcaatgac tttacccgaa aaaatctgtt ctttggcaat 2324641 tgttttttct tctaatgatt tcatttcttc atctcccgtt ctgtctctat atgatgcccc 2324701 atacatttta tcatactaga gcaaaagggg gcttcttcgt gaaagtgcac cgcatgccaa 2324761 aaggtgttgt cttagtcgga aaagcatggg aaattcgagc gaagttaaaa gagtatggac 2324821 gcacatttca atatgtgaaa gattggatct caaagccata aaagttgaaa ctttagctcc 2324881 tttatattac ggtcaataca aagcctaaaa aaggagtgtg cacatgagaa agcgcaaatt 2324941 gggtacatct gatttagaca ttagcgaagt cggactcggc tgtatgtctc ttggaactga 2325001 aaaaaacaaa gcattgtcca ttctggatga agcgatcgag cttggcatca actatttgga 2325061 cacagcggat ttgtatgacc ggggacgcaa tgaagaaatt gtcggtgatg cgatccaaaa 2325121 cagacgccat gatattattc tggcaacaaa agcgggaaac cgttgggatg acggaagcga 2325181 gggctggtat tgggaccctt caaaagctta cataaaagag gcggtaaaaa agagccttac 2325241 acgtctgaaa acagattata tcgaccttta tcagctccac ggcggcacga tagaggacaa 2325301 cattgatgaa acgattgaag cgtttgagga attaaaacaa gaaggtgtca tccgctacta 2325361 cggcatttct tccatccgcc cgaatgtgat taaagaatat gtaaaaaaat caaacatcgt 2325421 cagcattatg atgcaattca gcctgtttga cagacgccct gaggaatggc tcccgctttt 2325481 agaggaacat caaatcagcg tagtcgccag aggtcctgtt gccaaagggc tcttaactga 2325541 aaaaccgctt gatcaagctt cagaaagtat gaaacaaaac gggtacttgt cctattcatt 2325601 cgaggaactg acaaatgccc gtaaggcaat ggaggaagtg gctcccgatc tttccatgac 2325661 agaaaagtcg ctgcagtatc tgctagcaca gccggctgtc gcttcagtga ttacaggcgc 2325721 cagtaagatt gagcagttac gggaaaatat tcaggcagca aatgcacggc gtttaaccga 2325781 agaggaaatc aaagcgctcc aatctcatac gaaacaagac atttacaaag ctcatcgctc 2325841 atagcagaaa aaccagcacc tgtacgggtg ctggtttatt tatattgatg ccaatccatt 2325901 tggctttcat ttaggagttc ttcaaagctc ttattttttt cgatctcttt tttctttcta 2325961 atctgttctg ctttttctct tttctgcctc ttttcatcct cttccttcaa ttggctcttc 2326021 atctccataa gctttgcttt gatatcggat tgaaggccgt cttttagctg gtgtttgtca 2326081 atggattttt gttttttcat gcagacttcc cccatgtttt gttttgaagc cagtttatca 2326141 cggagcatat aaactgaaca agcagactct cttctgatca ctttctcagc gtagcagtgt 2326201 ttaggtataa tgatcttaaa cacgaattgc ctatatattt cgttgaaagg tgctgtgact 2326261 tttgaagaaa atccttttgg ccattggcgc gctcgtaaca gctgtcatcg caatcggaat 2326321 tgttttttca catatgattc tattcatcaa gaaaaaaacg gatgaagaca ttatcaaaag 2326381 agagacagac aacggacatg atgtgtttga atcatttgaa caaatggaga aaaccgcttt 2326441 tgtgataccc tccgcttacg ggtacgacat aaaaggatac catgtcgcac cgcatgacac 2326501 accaaatacc atcatcatct gccacggggt gacgatgaat gtactgaatt ctcttaagta 2326561 tatgcattta tttctagatc tcggctggaa tgtgctcatt tatgaccatc gccggcatgg 2326621 ccaaagcggc ggaaagacga ccagctacgg gttttacgaa aaggatgatc tcaataaggt 2326681 tgtcagcttg ctcaaaaaca aaacaaatca tcgcggattg atcggaattc atggtgagtc 2326741 gatgggggcc gtgaccgccc tgctttatgc tggtgcacac tgcagcgatg gcgctgattt 2326801 ttatattgcc gattgtccgt tcgcatgttt tgatgaacag cttgcctatc ggctgagagc 2326861 ggaatacagg ctcccgtctt ggcccctgct tcctatcgcc gacttctttt tgaagctgag 2326921 gggaggctat cgcgcacgtg aagtatctcc gcttgctgtc attgataaaa ttgaaaagcc 2326981 ggtcctcttt attcacagta aggatgatga ctacattcct gtttcttcaa ccgagcggct 2327041 ttatgaaaag aaacgcggtc cgaaagcgct gtacattgcc gagaacggtg aacacgccat 2327101 gtcatatacc aaaaatcggc atacgtaccg aaaaacagtg caggagtttt tagacaacat 2327161 gaatgattca acagaataaa aaagcgaaag gcctcttcgg ctctttcgct tttttatgtt 2327221 acagaacgtc ggtaatgcca tccatatttt ctctgatcca ttcaatcgca agatctatcg 2327281 ttgtaaactc ctgcgtctcg aaggtcattt catcctgcaa tagccagaca tctttcttga 2327341 tggactctgc tcctccgatt gaccagtgaa gcaaggtata aggatggttt tgattcagga 2327401 aggataccca cgttttattt tgtgctgtgt tcttcattgc cttcagcttt tgttccacgt 2327461 ttcgcgtctc ctactttact aatatgctca ttctggggct gagcatttca gccgggcttt 2327521 tcagcgccaa tgttttggct ttttcattgt aatcgatcgt catttgatcg tcaaaaaaca 2327581 ctttttgcga cgattggata tacagcggaa tgccgttcgt ttccagctgc tcgcactgtc 2327641 ccgttaattc ttctgccagc cagattgtcg ggacaccgct taccgcgcag ccgcatcctt 2327701 ctgcatcgta acgaagctgg gctttttttc ccgggttggc gtcaaacgcc tgctgcagtg 2327761 cctgttttgc tgcatctgtc acatgtatgt tcataaggtg aaacccccgt tttcatcatt 2327821 ttcgctattg tagcatacaa tactgccatt cgcattgttt ctgccttttt tccaccgctt 2327881 cgcattttct tctgcagtct tgatccactc atctttccct tgtatatact gattgatgct 2327941 gtcagggtgc tgggccgcca gctgtttttt gagaacggcg tattctttcg ctatgtttgg 2328001 atgagctctg agataatctc tgaataacag atgcctttca atagcagggt ttccctgttc 2328061 gtacatatgg acatgatgag tgcgtttatt tccgcccttt tggaaataac gcctgcccgc 2328121 tataccgttc tcaccttttg gtgtatagcc gttggccttc atttgttcat caaattggct 2328181 cacggcttca atgcttctga cttcaattaa catatcaatg attggcttcg ctgccatgtt 2328241 aggtattgat gtgcttccga tgtgatgaat agcgataatc tccggcccga acacaagttt 2328301 cagccgttct ttttcttcat cgaaacattc tgcccatttt tcgttgtaga gaatgatctc 2328361 aacttttctt ttcggataca aatgaaagac cgacagcaat agaccctgcg ctgctttgac 2328421 ggtttctgcc ttttggaatc cggcctgtgt atagagtgac acagccgggg tattgttctc 2328481 ggctgtgact acttcgattt tctcagcgtc ttcattatga tcaatgacaa attgcagaag 2328541 cgctcgtcca attccttttc tgaaaccgtc aggatgcaca acaagcctgc aaatggtgag 2328601 ataatgcatg tttttctcat atgaaatgac accgatcagc ttgccgtttt tccgatatcc 2328661 cgcaaaccgt tcatgggatg cttgaatatc ctttaccttc tcttgtaaag cgggaatacc 2328721 gtcaaaaccg ataatctctg tttcctttat gtaggcgggg atctgtacgg ctaaaatctc 2328781 acgcgctata gtggcttcct tatgctggag aaattcaatc attcgtgttc tcctgaaaca 2328841 gccgctgtct gtcgactttt gcgacgcgga ctgcatacga ctcgtaccaa acgcttcttc 2328901 ctttttcttt tgctgcttga tgttcagtgt gatgcctcca atggttaatt gcgtccatac 2328961 tgtcccaata ggaaactgtg atgccccttc catccgcttc acgtacgctt tccacgccta 2329021 aaaatccagg ctgatccgcc gcaagtgata ccatccgctc cgctgtttct ccatatcctg 2329081 tgtcattttc gcttttgaca gaagaaaaaa tgactgcata gtaaggaggc tcaggtgttt 2329141 ttgataaaaa atccatcata tttccccctc atatgttttt gacaaatagt accctgtctt 2329201 ggcccgggcc atcatagttt gcaaacactg agatgccatt taccgttttg gtgccctttt 2329261 caatatcaaa ccccaatttt gtgtgatatg cgattgatac cttattcaca ggtgaagtga 2329321 cacacttcac ccgggtgcag cccctttgtt ttactgtttc gataaataca tcatacaatt 2329381 gtttcccaat ttgcattttt ctgaaatccg gatgcacacc ggaaaaatga atgtacgccg 2329441 tttcaggatc ggattgcgat tgaaatccga ttaaaaatcc cgtcatgctg ttatgttcgg 2329501 atgtaataaa gcttgtgtcc tgaaaatgct caaaaaatag tctcggcaat ttttctttca 2329561 gctgtctgcc gccccaccat tcattcagta cagacgttac catttcataa tctgaagacg 2329621 tgattgttcg aatatccatt acgatttgat ctccctccgt ctggcaaaac gaatgtcagc 2329681 tctttttctc acaatataaa aattatattt tgcctggctg gaattgtaaa tgccttcttt 2329741 cctgtatcat acgtttccag actgccgagg gaacaatgtt tgatcatttt acgcctattt 2329801 ctcccccaaa caggaggaga gactttacag cacaatatca agcacttgat caagtttcag 2329861 cttataaagc tgatcctcgt ctccttttat ccatactgct ttttcaaact cttcataccg 2329921 gcagattttc ccggtgcagc agacaatctc accgtcctga aagcagctga cagtgatatc 2329981 ctgagcaaac tccatcgcgg cgcaaagcgt ttgattcatc tcttccagct tatcggggtc 2330041 aaggatcggc ttttgcagct tctgtttaag tcgctttctc tccagcaggc tttgcttatg 2330101 ttccggcaga aacatcctgc tcccttccca cagcaggttg ccccttttta aatggtcgtt 2330161 catttataat gcccccctat tttagccgca cgttcaaatg cctggcctgc cgctgtcagt 2330221 gacgccgccc tgatgattgc tgtatcgccg aatcgatttt taatgccatc catcacatag 2330281 cctaggctca ttttctttgc ataatcctga aataaattga gctgccatat gtcatcagat 2330341 gagagctgag acagattgac accgaggcgg cggacgggtt tcccgtccca aaatgtaaga 2330401 aacagccgtc gtacagcctc atatacatcc tgcgtagaat tagtcggctc tgccagcttc 2330461 acttgccggt tgaagcccgt cggccaatca aaatcagcac cccggcagct cactgacact 2330521 gtctgcccca tgaccccggc gtttcggctt cgcctgcaca cctcttcact cagctcaagc 2330581 aatacgacct tgatttcttt gtcaaagtgt tcgtagtctc tcgggagagt cattccatga 2330641 cctatcgcct tttgcccgtc cagagacgaa gttgacacag gggaatagtc gattccgttt 2330701 gccgtcatcc acagcacgtg gccgttaatg ccccatttct tttttaaaag atcgagcgga 2330761 aaagccgcga gcccgccgat cgtgctgatg cccattcgat ttaaatgatg cttcatgcgg 2330821 ctcccgacgc caaacatgct gcccaccggg agcggccaca tttcggtttt catattttct 2330881 ttcgttaagg taaaaatacc gttcttattc tttttggcaa aattgtcaca cgcaattttg 2330941 gccagcgctt tgttagggcc gattccgacc cgtgcataaa cgccgatctc ccgcatgatt 2331001 ctgccctgaa tgcttttcgc gatctccatc ggcgtcccaa acagcttctg gctgcctgta 2331061 atgtccatga actgttcatc gatggaatac ggctccacaa ggtctgtata ctcctcgaga 2331121 atggccgtaa tttgcagtga tacatcaata taccgctgca tacgcggccg gagcacaaca 2331181 gcctcaggac acttttcctg cgcctcccac agccgtgaag cattcaccac acccttttgt 2331241 ttcgccagcg ggcaggcagc caatacgact ccgccccttt tttcagggtc acccgaaaca 2331301 atgacgggcc tatttttcaa atgtggattt tccgctttct ctacagatgc ataaaacgat 2331361 tgcatgtcaa cgagaaaaat cactttttct ttcatcatac acacctctaa aaagaactta 2331421 tgttcgcttt tcattatatg cgaaagtatg ttcgttttat actggtaaat gattcttgtc 2331481 tgacagaaaa tatgatccaa gggtttgaga gaagaaaaac atttagtaga ataaaagcga 2331541 agcataagga taggagagtc atgatggaga aatttgtcga aaaaatgctg ggacaggcat 2331601 tgcggcaata cggcagaaac gttgctatag atccgttaag cccgtatgaa aaacaaagcc 2331661 tgaaagcggc tctacaagag agacggaatg aagaaccaga tgaggatttg catgcgcata 2331721 tagaagatat catttatgac tatgtcacaa accaaggcct gttctcttaa acgcatgact 2331781 gtcagttctt tcagccgctg atgcggcttc cctttgaaaa caccgcctga aacaaataaa 2331841 cagtctcagg cttacagaaa aaaagcagga ttttctcacg ctccatagat tcatatggcc 2331901 tggcgtaaaa ttcccctcaa tgctcgcgca aaacggaata agctgtccat gatcacgcgt 2331961 atacactttt tcgaagagat gtgctctctt gttctgtcat gcggtccatg ccggttttca 2332021 gcgtacatct tgatctcata gccggtttca ctgccgatat gatccacgtt ctggcggctt 2332081 aaactaacac accctcactg accaatcgct ttgcttttca tcggacatcc cgtcattttc 2332141 cttctttcaa gatgtaaact ccgtcagcca cacgcatcct caacgcatag tatattgcca 2332201 tccatacaat caggcatact acatgtcaat aacgaaatat tttgaacgat ctattggaga 2332261 aggaaatttt ttcatatatg atagagaaag atcatacata caggagagaa tataattcat 2332321 gaagaaatgg aaagatatcc acccgatcag ctggacaatt ataatcggaa ccattttcgg 2332381 cagaatggca acatcgatga gcattccttt tttagcgatt tatttgacag ccgtccaagg 2332441 cgcatcagct tcctatgcag ggctggtcat cgccgcgagc tcatcagtcg gcatcctcgc 2332501 aagcttttac ggcggatata tctcagataa attcggcaga aaaaacatga tgcttgtatc 2332561 gattttcgga tggatgctgg tatttgcagg ctttgcggca gcatctaatc tctgggtgtt 2332621 ttttgtagta aacgcattaa acggtctttg caaatcactg tttgagcccg cttcaaaggc 2332681 cttgttgtct gatatgacag aagaaaaaac gagactgcta gtttttaatt tacgctatgc 2332741 ggctattaat atcggcgttg tcttcggacc tgtgcttggc ctatatttcg gctcatcgca 2332801 atcgactacg ccctttttgg tgcctgcagt catttacgga ctatacggaa ttgtgcttgc 2332861 cctccaattt aaaaaacatc catccttatc agcaccagcc cagtcccgaa atatgagcgt 2332921 gcgggaagcg tttatggtca cgcaaaagga ttatcttttt accattgctt tggtcggcat 2332981 tacgctatgc accttcggct actcacaatt cagttccaca ttccctcagt atatggcgca 2333041 gaaccccttg atcggcaatg gaacgaagct gtatgggctg atgctgacat taaacgcaat 2333101 cgttgtgttg gcgacgcaat ttcccattgt ccattttgca aaacggtttt cgccgctttg 2333161 ttctctgatg ctcggtaatg tgatggttag catcagcatg gccattttca ccgtatcaca 2333221 cggtgttcca tcaattgtga tgattgtcat cacatttaca atcggcgaag tgcttttatt 2333281 ctctatgatg gatttgtatg tagaccagat tgcaaaacca ggattaaaag gcacttattt 2333341 cggggcaatc ggtttttcac agctcggaaa cgtcatcggc ccttgggtcg gggggatatg 2333401 tatagacctg tttggcgctg gccggccgat ttatattttt tctgtcctga gcggcattac 2333461 cctgctcggc ctgccatttt tagcgttcgc ctatcggcaa atgaaaatgg agaccacaaa 2333521 acaccgttcc cgtctggaaa agccgcttta aataaaaaac ggaagagaat gaatctctcc 2333581 cgcaaacatg aggtgaagaa catgaatata ggtgatgtga tgtttcagct gtttgtattt 2333641 attatatttg ccgctgtcgt ctttgcggct gttacaggct tcaagtatgc gaaaaaccga 2333701 aaagcgcagc tggatcgcat tgagaaaaag ctgaacagcc tgtccgaaga tcacgattaa 2333761 cagcttgggg caacgagctc taccttaatc cggtctggat cctcacaaaa gactgcataa 2333821 tgcccgtctc ctccggcaaa aggatgcctg tctcggtaca acacacgata gccttttgcc 2333881 gtcaattttt cagtcatctg atcgacttga agcttggatt cagcatgaaa tgcgagatgg 2333941 ttcagaccga ctcggcatct atggtattcc ggctctagaa atggctcttt cgcctgcaca 2334001 atcactaggt aaaaacgatc tttcttccag ctgatgcctg agctccattt ttgatactct 2334061 ttataaccaa gttcttttaa gaaccagccc caaaaccgcc tagacgcctc caaatcagag 2334121 acatacagtt caatatgatg cacatttcat accctcctta ccaacacttc ctcgacctta 2334181 tgcccgtctc ccttacgcaa aatgagatct gacctgaatt tagttggcaa aatattttca 2334241 tataaattcg gccggttgac actctcccaa atcgaggctg ccatctcgtc agcctcctga 2334301 tcggacaagt ctttaaattt atgaaaatat gaatcaggat tttgaaaagc tgtttcccga 2334361 agcaggcgaa aacgctctaa ataccaagtg aaaatccggc tttcctccgc atccacataa 2334421 atcgaaaaat caaagaaatc ggaaacaaaa atacgcgggt tttcccggtc atcctccaag 2334481 gtgggcgact gaagaacatt aatgccttca ataatcacaa tatccgcctg ttctacaacc 2334541 tcgaacacac cttcctcgcg gtcataggtt agatgggaat acaccggggc ctttacgctg 2334601 tcctttcctg attttaagtc attcaaaaat tcgagcagcg cctttacatc atagctttca 2334661 ggaaatcctt ttcttgacat catatttttc tttttcagct cggcagtagg aaataaaaaa 2334721 ccatctgtcg tgataaggct cacttttgga cggtcaggca aacgcgaaag cagcttctgc 2334781 aagatccgcg ccgtcgtgct ttttccgact gcgacactgc cggcaatgcc gataataaac 2334841 ggaattttgg ctgaatgtgg gtgcttcaaa aaaacattga catgcttatt gcgttcagcc 2334901 gcagacttga catgtaaatg aagcaagcga acaagcggaa tatagatcgt ctccacttct 2334961 tcaacagata gataatcatt caatccttcc acagcttttg cctcttcttc agatacagca 2335021 atcgacaaat gccccccaaa accagaccaa gactcccgat tgtgctgtgt atataaagta 2335081 tgtaggttaa gttctttatt tttcactgtt tacacctgac tctctgtagg ttaaaaccct 2335141 tacaaagatt gtaacggaaa accttttcac tgtctgctta tttttcattt cgttttttta 2335201 gcaaatcagc accgattcgg ttatacgcag ccatttcatc ttttggaacc atgcttcctc 2335261 ccgttcccca gacgacatgt acggcatgtt ccatcttata tttctgagca tagcgccttc 2335321 cctcttctgt cgaaaaaagc tgaaccggcc cgaacatgcc agcaagagca gagggctcta 2335381 aatatttatc ttcagataca gccagcatat gaagcaaagt ataaagcgta ttgtcctcta 2335441 ccgtataaca gccgctcaga agcggttcaa tcagcttgcc gacaaatcct gacggcctcc 2335501 ctacggcaag tccgtcagca gccgtctgat tatccaggcc gatatcctgg acggagatct 2335561 tctcgtgaag tcctgaataa agccctaaca gcatacaagg tgaatgagtt ggttctgcga 2335621 aaaacacatg aacatcatct ccgtataaaa gcttcagccc aaatgctaca ccgcccggtc 2335681 ctccgccgac tccgcacggc agatacacaa acaagggcgt ctcaagactt ggctttatat 2335741 tcatacagtc aagctgtgtt tttaatcggc ttgcagcaac agcatatcct aagaacagct 2335801 gacgagaatg ttcatcatca ataaaataac agaatggatc ttgttccgcc tgccgtctcc 2335861 cttcgttcac cgcttcactg taatctgttt cgtactccat aacagtgact cccttttggc 2335921 ggaggagatc ctttttccac tgcttagcat cggcggacat atgcactgtc acgcgaaacc 2335981 cgagtgccgc gccgatgatg ccgatgctta aacctagatt tcctgtcgaa ccgacagcaa 2336041 tcgaatagcg ggagaaaaac ccggtaaacc gctcttcctg taagatgcgg taatcatcgg 2336101 tttcctgaag cattccttct tgaagcgcga gattttcagc atactttaac acttcataaa 2336161 tcccgcccct cgctttaatc gatcctgaaa tcggaagctc atggtcgcac tttaaaagcc 2336221 atcttccggg aaatggctgc tgatatgccg cttccagctt tcccttcata tgctgcacct 2336281 caaaaagcgg agactcgatg attcctttag cgcctttcgt ctcaggaaac acctcggcaa 2336341 tgtaaggtgc aaaccgctgc attctttttt ccgcttccgc tatctcggtt gcccactcat 2336401 ctgcacgggg taatggcccc tctttcttgc ctgaatttgc ccagaataca ggctctgcat 2336461 caatcagttt ctgaataaac ggatctttaa gcagagcatg aaggacttct gaatgaactg 2336521 acattcaaca atctctccct tccactatca aaaactgccc cgtgagaaac aagccactcc 2336581 accacaggca gttctatcat tattttttca tgagcgcgcg tcctgccagc ttttctacaa 2336641 gagctggaaa cagctgatac agcttagtgc cggcattcat taaacgcgga agattgatct 2336701 cccgcttttt cgtaaaaatt gcagctgtaa tttgagctgc cacgtcatca ggatcaagca 2336761 tccagcggcc gacatttttg gcgtagtccc cgcctttatc agcaatggaa aaaaagtccg 2336821 tctgaatcgg gcccgggttg actgttgtca cataaatgcc ggttcccgaa agctccatcc 2336881 gcaaagcgtt tgagtaacct aacacggcat gtttggtcgc ggaatacagg ctagacttcg 2336941 gtgtggcgat tttccccgct tgagaggcga tattgatgat atgtcccttt ttttgctcaa 2337001 gcatttgcgg aagcaccgct tttgtacagg cgatcaggcc gaagacattc acatcaaaca 2337061 tcgctttcat gtcatccaat gtagagtcta aaaccgtttc aaatataccg aagcctgcat 2337121 tgttaatcag tacatcaatc gagccgatct gatcgcggac ccgggcgata tcctctaggc 2337181 ggccgacatc cagaggaaaa atctcacact gtccgctcca ttcctcggtt attttccttt 2337241 tgatttctat caaacgatcc tcgcgtctag ccgacagcag gacatgggct ccttcagccg 2337301 cgcataagta tgcgattctt tctccaagcc ctcctgaagc gccggttatc caaatccttt 2337361 ttcccgctat atgtttcacc catttcacct cttcattgtt ttaaagtata cggtatttcc 2337421 ttcccaatat gacgtgatgg cttcttcagc ctccaacaca tcaaggtgac ctgccgtttc 2337481 tgacatcgtt aaaaacaatt ccttttcata tacagcagga aaaagctgct gacagacctg 2337541 aaaagcggtc atcggctttt catccagcat gcgacgcaca tcctccgtcc tgttcctctg 2337601 cttgtcaaaa cgcttctcaa tcagcgcttg tacactggtg ataggctcgc cgtgaccagg 2337661 aaatacgatt gttggatcaa gttgagacag ccttcgcaat gaccgctgat aatccactaa 2337721 aggctttgac ctgacgtctc ccgctttcgg cgcttccaaa atcggattag acgagctgtt 2337781 tgccagcagt agatcgccgc caagcatcct tccgcttttt tcatggaaca gaacaatatg 2337841 cgattcagca tgtccaggca tctccaacac agaccagccc tcaagcccat ctatgcccat 2337901 accttctctg attgattttg tcagagatct cgtacaggaa aatgcgtacg ctgatcgaat 2337961 cagcttttcc gccttccccg tatcaaatgg aacgcctaat tcaggcagca gcttttgaaa 2338021 aaaacgtttt tgccaatcca taaaggcttg attttggctg atataaggtt cgttgaatgt 2338081 atgcccaatc acttcgattt catctgaaaa gacatcaagc aagcctgcat gatcagcatg 2338141 atggtgagtc agtacaacct gctcgatatc tgacaatttc acatttacag cggcaagctg 2338201 ctcttgtaag gctctggcag cctcttttgt attcggcccg gcatcgataa gtgtcagcgc 2338261 atcacctttt acgaggtaaa cgataacatc gccgacagca aacggtgtcg ggacgcggat 2338321 cgcaattaca tcttcagttg tcatcctttc gctccttgtc ttcattcatt attcatattt 2338381 tagctttttc tcggtcttgt gtcattattg cagaatgaga acaaaccttt ttgaaaaagc 2338441 tattgacatt agcttgtccg ccattgcata atgaacaaca aactaaaacg agaaccattg 2338501 gaacgctatg acgaggaata gtatacaagg caatggccta agagagcgat acccccggct 2338561 gaaaggtgtt gcggcccgct tgtttgtaga acctgccctc aagtcgcggt taggaaaacc 2338621 taaacgtttc ccgcgttacg gggatttgag ctgagcacaa tttgtgctaa tgagggtggt 2338681 accgcgaacc ttttcgtcct ttacgtgatg aaaaggtttt ttgttgttct aatagaagga 2338741 ggatatcaat gaaaaagata ggatttgtcg gcgccgggtc aatggcagaa gcaatgatca 2338801 acggcatttt gcaaagcggc atcacaaaac cagaacatat ctatattaca aatcgctcaa 2338861 atgacgagcg tctgattgaa ttaaaggaaa cgtacagcgt gcgtccatgc agagataaaa 2338921 atgagttttt cactcacacc gatatcatta tcctcgcttt caaaccgaaa gacgcggcgg 2338981 aaagcatcga cagcatccgg ccgtatatca aggaccagct tgtcatttca gtacttgcag 2339041 gccttaccat cgaaaccatt cagcattatt ttggcagaaa gctcgcggtc attcgcgtca 2339101 tgcctaatac atcagcggca atcagaaaat cagcaaccgg attttccgta agcacggaag 2339161 caagcaagaa tgatattatt gccgcaaaag ctctattgga aacaatcggt gatgcaacac 2339221 tggttgagga gcggcatctt gacgctgtca ctgcaatcgc aggcagcggc ccggcctatg 2339281 tgtatcgtta tattgaggcg atggaaaaag cagcacaaaa agtaggatta gataaagaaa 2339341 cggcaaaagc actcattttg cagacaatgg caggggcaac agatatgctc ctccaaagcg 2339401 gcaaacagcc ggaaaagctg cgtaaagaaa tcaccagtcc tgggggcact acagaggcag 2339461 gtcttcgcgc tttacaggac tcccgctttg aagaagcaat tattcactgt attgaagaaa 2339521 cagctaaacg gagcgcagaa atcaaagaac agtttgccgg tgccgcctta gagagacatt 2339581 cttagatgta aggacaaaaa cagaaggcac agtgccttct gttttttatt tttcccgcag 2339641 cagctggccg gcagattctg attgctttaa tagcgcggag atcgtaaatg aaagcaaatc 2339701 gggaagcact tcaaaggaat aaggcatata caatctttcc gtccatttat gcgggtcttt 2339761 accagccgga ccgacattta aaactgggac atataaagcc tgatttttac cgcttggcaa 2339821 tgaataccct ctgttaaaga gcggcatatt gcttgtgtat gcatcaacct cctgtttttc 2339881 cagctgaaga taactcaagt ccgaaagtcc ggggaagtac tgaacctccc gtaatgcaat 2339941 gccgtatcgc tcagccgcat aatgctttat ctgatctgct gtatttctga tcaattgatc 2340001 atcctttgaa gaaacagctg gataaagcgg cggactataa aacagaacga tgagcggcgc 2340061 atcctcctta caaagcgaag caagctcaga aacaattttc gtcgaaaaat ccctgtctcc 2340121 aagctccccc ctgttagcaa aggcataatt tagagcccgc tctgtttccg agatccccgc 2340181 acgctttttt gcacgcgaga ccagctcatc aaatgtcaaa acagtgacgt cccgctcaat 2340241 cggctgaaat ggctcaaatt gttgaaaatc ctgtgttttc ttccgaacgt tcgacatgat 2340301 ttcctccgcc gcctgttctg ctgttttaag cagcatctga tgcagctcac tagctgagcg 2340361 tttcattgac agcacattaa ataatgtgac ggctgtatgc ggtgtctgga ctgaatatgc 2340421 ctctttcaag tccttttgca ttaagtttac cggcggcgga gtgacctcgc catcaacctt 2340481 ttcgcaataa tcagcattca gttcaagcaa acggttaatc tcagatacca ttaaatttgc 2340541 gtttagacct gaaaacggct ctccaacatg tgtctcaatc cccttgcaga aaaaacccgc 2340601 aagcaccttg ccaatgcttc ctgtataaaa atattgctgc tgatcgccgg gaaatttttc 2340661 aaacatcggt tcggcattca ggcaagcggt taatgtgata tcatgctttt tctccatctc 2340721 cttcaatgca ggaaccgctt caatcatgcc tcttgaattc acttcctcgt ccggaaccgt 2340781 tatcaacagc agattgccct caaaatgccc gttcattgcc ctctccagca tcgacagttg 2340841 aatacaaagc cccgctttca tatccatcgt ccctcttccg aacagccagt ctccgctttc 2340901 ggcatctctt ctcacacgtt ccgggagcag ctcttttttc tctaaaaagg agctcaaaag 2340961 ctcagcaggc ttgcaagcca tatgtttaaa ttcgccgtaa tcttctatgt caacgacatc 2341021 aaaatgactc agcagaagca ctgtcttttt gacattcttc tttttgacta gagccgtaag 2341081 aaaagatctg ccatcgtcca tcggatgaag tgttacatca tcagggtgct tttgaaaata 2341141 gggcttgtcc ttcaaaataa aataaagata ctctgcaagc gctacctcgc cctttgaacc 2341201 ggtgatgctt tcgtattgca caagagaagt taaaagtgcc agcaattcgt ccttcgtctg 2341261 ccaattcatt gattccgccc ctcctatgaa taaaaatgct tctatactga aaaataaact 2341321 gatttctcgt ctattataca gaaatgtttg acaaaagcgg ttcatttgag cagtttatat 2341381 gacgggaaag aaatgacttg atataatcaa tctctaaaaa ccttacggga ggcgaaagaa 2341441 atggccagaa aattatttac acctattaca attaaagata tgacgttaaa aaaccgcatt 2341501 gtcatgtcgc caatgtgcat gtattcttct catgaaaagg acggaaaatt aacaccgttc 2341561 cacatggcac attacatatc gcgcgcaatc ggccaggtcg gactgattat tgtagaggcg 2341621 tcagcggtta accctcaagg acgaatcact gaccaagact taggcatttg gagcgacgag 2341681 catattgaag gctttgcaaa actgactgag caggtcaaag aacaaggttc aaaaatcggc 2341741 attcagcttg cccatgccgg acgtaaagct gagcttgaag gagatatctt cgctccatcg 2341801 gcgattgcgt ttgacgaaca atcagcaaca cctgtagaaa tgtcagcaga aaaagtaaaa 2341861 gaaacggtcc aggagttcaa gcaagcggct gcccgcgcaa aagaagccgg ctttgatgtg 2341921 attgaaattc atgcggcgca cggatattta attcatgaat ttttgtctcc gctttccaac 2341981 catcgaacag atgaatatgg cggctcacct gaaaaccgct atcgtttctt gagagagatc 2342041 attgatgaag tcaaacaagt atgggacggt cctttatttg tccgtgtatc tgcttctgac 2342101 tacactgata aaggcttaga cattgccgat cacatcggtt ttgcaaaatg gatgaaggag 2342161 cagggtgttg acttaattga ctgcagctca ggcgcccttg ttcacgcaga cattaacgta 2342221 ttccctggct atcaggtcag cttcgctgag aaaatccgtg aacaggcgga catggctact 2342281 ggtgccgtcg gcatgattac agacggttca atggctgaag aaattctgca aaacggacgt 2342341 gccgacctca tctttatcgg cagagagctt ttgcgggatc cattttttgc aagaactgct 2342401 gcgaaacagc tcaatacaga gattccggcc cctgttcaat acgaaagagg ctggtaatgc 2342461 ccataagaga tatcctgtag aggatatctc tttttttatt tttagagaaa cgatcggcta 2342521 aggttctccg tctccctagt agaaccaatt agaggagatg actccaatga aatcagcttg 2342581 gatggaaaag acatatacaa ttgacggatg tgcgtttcat acacagcacc ggaaaggatc 2342641 aagcggtgta acgattgtct ttgaggccgg ctatggtact tcttctgaga cgtggaaacc 2342701 attaatggcg gacattgatg atgaatttgg cattttcaca tatgatcggg caggcatagg 2342761 aaaaagcggg caaagcagag ctaaacgaac agctgatcaa caagtgaaag aattggagag 2342821 tttgcttaaa gcagctgatg taaaacctcc ttatttggct gtttcacact catacggagc 2342881 tgtcatcacc ggtttatggg cctgcaaaaa caagcatgat attatcggca tggtccttct 2342941 tgacccagct ttaggcgatt gcgccagctt tacctttata cccgaagaaa tgcacaaatc 2343001 acatacgaga aagatgatgc ttgagggcac acatgcagag ttttcaaaaa gtctgcagga 2343061 gctcaaaaag cggcaagtcc acttaggaaa catgcctctt cttgtgttgt catcaggaga 2343121 acggactgag aaattcgctg ctgaacagga gtggcaaaac ttgcacagca gcatattgtc 2343181 tctatctaac caaagcggct ggattcaagc taaaaacagc tcccacaaca tccatcatga 2343241 tgaacctcat atcgttcact tggctattta tgacgtatgg tgcgcagcgt gccagcaggc 2343301 cgctcctctt taccaggcag tcaattaacg taaaaaaaga ccgggccgta agggattccc 2343361 ggtcttttat attattttgt ttcacggtga agggtatatt tctttaaacg cggtgaatat 2343421 tttttcagct ccaaacggtc tggattggtg cgtttatttt ttgttgtgat gtaatttcgg 2343481 tctcccgttt cagtgcaaag ctaaagtaac atttactctc ataattaaca tctccttata 2343541 aaacgtaatg attacgtttt attatacaac gtcatcacaa attgtcaaat aagagctccg 2343601 ccttcagcct cgcgggacgt ttacctctaa gaaatcatat gccgccacgc tattggggaa 2343661 aacgtcaacc gcttcttttt gaagctccaa agaagcatct ccctgatatc ttgcgctgat 2343721 atgggttaaa atgagctgct tcgctcttgc ttctttcgct gttacagccg cttgttccgt 2343781 tgtactgtga taataatcat aagcaagttt acggtcttcc ttagcaaagg ttgcttcatg 2343841 aacaagcaca tcacaatccc tcgcaagctc ttttagtttg tcacttactc tcgtatcacc 2343901 ggagaacaca acagatcttc cctttttagg aggctccaga aaatcattcc cattgatgat 2343961 tcgtccgtct tcaagcgtta ccgtttcgcc ttttttgatt ttctgatata caggtccggg 2344021 cgggatgttc atttctttta atacgtcagc cttcaaggaa cccggtacgt ctttttcctg 2344081 cacacggtac ccgaaggctt ccactccatg aataacagat accgctgtga caataaactg 2344141 atcgtcctca aacacgattc cttcttcaat ttcctggatc gcaagcggat atgtcaaatg 2344201 ggttttcgtg acggcaaggc ttgtttcaat aaacgccttg atccctttag gtccgtacac 2344261 tgtcagctcg tcctctccgc cttgaaagga acggctcccc agaagccccg gaagtccgta 2344321 tacatgatcg ccgtgcatgt gtgtaataaa gattttctct attttacgag gtttaatcgt 2344381 tgtatgtaaa atttgatgct gtgtggcttc cccgcagtca aaaagccata ccgaacgcct 2344441 ttcttcaagc aattttaatg ccaccgacgt tacatttctc gccttggcgg ggatgccggc 2344501 tcccgtccct aaaaaaagta attccacgtt tccttcctcc tactagaacc agatacctac 2344561 aagaatacag gatcaagcgg aaaatgtgaa tcttgcctct gaaaagaaca atcctttcgt 2344621 gctagaaaca ttttttcagc attctgctta aaaaagggct taaatgtttg ctttcgttga 2344681 attttagatt taaaatgaag gaaatatacg gggtgtacta aaataaagct tcgaataaag 2344741 tgaggtactt ttagtgaaaa caaaccaaca accaaaagca gtaattgtca tattcggtgc 2344801 aactggagat ttagcaaaac gaaaattgta tccgtctatt caccgtttat atcaaaacgg 2344861 acaaatcgga gaagagtttg cagtggtagg agttggaaga agaccttggt ctaatgagga 2344921 tcttcgccaa actgttaaaa catccatttc ctcatctgca gataagcata tagatgattt 2344981 cacgtctcat ttttactatc acccgtttga cgtgacaaac cctggttctt atcaagagct 2345041 aaacgtattg cttaaccagc tggaagatac atatcaaatt cctaacaaca gaatgttcta 2345101 cttggcaatg gctcctgaat tcttcggaac gattgcaaaa acattaaaat cagagggtgt 2345161 aacagctaca accggctggt cccgccttgt catcgaaaaa ccgttcggcc atgatctgcc 2345221 aagcgcacag gcattgaata aagaaatccg cgaagcattt acggaagatc aaatttacag 2345281 aatcgaccat tatctaggca aacaaatggt tcagaacatt gaagtgattc gatttgccaa 2345341 tgcgattttc gaaccgcttt ggacaaaccg ctacatttca aacattcaaa tcacatctag 2345401 cgaatcacta ggcgttgaag accgcgcaag atattacgaa aaatcaggcg cccttcgcga 2345461 catggtgcaa aaccatatta tgcagatggt tgcccttctt gcaatggagc cgcctatcaa 2345521 attgaacaca gaagaaatcc gcagcgagaa agtgaaggtg ctgagagcac tgcgtcctat 2345581 tgcaaaagac gaagtggatg aatactttgt gcgcggacaa tatcatgctg gtgaaattga 2345641 cggtgtaccg gttcctgctt atacagatga agataatgtc gctcctgact ccaatacaga 2345701 aacctttgtt gccggcaagc tcttgatcga caacttcaga tgggctggtg ttccattcta 2345761 catcagaacc ggaaaacgaa tgaaagaaaa gtccacaaaa attgtcgttc aatttaagga 2345821 cattccgatg aacctgtact acggtaatga aaacaacatg aatccgaact tgcttgtcat 2345881 tcatattcag cctgacgaag gcattacgct ttacttaaat gctaaaaagc ttggcggagc 2345941 agcacacgca cagccaatca aactcgatta ttgcagcaat tgcaatgacg agttgaacac 2346001 ccctgaagca tatgaaaaac taattcacga ctgtcttctt ggcgatgcaa caaactttgc 2346061 acactgggat gaagttgccc tttcttggag ctttgtcgac tctatttctg aaacatgggc 2346121 agcaaacaaa accttatctc ctaactacga atcaggctca atgggaccga aagaatctga 2346181 tgatcttttg gtgaaagacg gcttacactg gtggaacata taataagaag aaaaaagccg 2346241 aaatagttta ctaagcattt tcggtctttt ttacgctgaa caaaggtata acaatctcct 2346301 taataacaaa acccccaaag cttaagagct tcgggggttt ctattgatta cttcatccat 2346361 tcagtatgga agatgccttc tttgtcagta cgctcataag tatgagcgcc aaagtagtcg 2346421 cgctgtgctt ggattaagtt tgcaggcagt acggctgtgc ggtagctgtc atagtaggct 2346481 aatgcgcttg agaatgatgg caccggcaca ccttgggcaa ctgcaagtga aatcacttgg 2346541 cgaagcgctc cttgatagct ttctacaata ttcttgaaat agctgtcaag aagcaggttg 2346601 tcaagctcag gctcgcgatc gtaagcttct ttgatcttct gaaggaatgc cgcgcgaatg 2346661 atgcaaccac cgcggaagat catagcgatt tcaccatatt tcagatccca gttgtattct 2346721 tcagaagcag ctttcatttg ggcaaatcct tgcgcgtatg aacagatttt actcatgaac 2346781 aacgcttttc tgaccgcttc aatcagctct tctttatttt ctgtaacagg cttcacttct 2346841 ggtcctgaaa gaagtccgct cgcttttaca cgctcttcct tcatagctga gataaagcgt 2346901 gcgaatacag attcagtaat aatcggaagc ggaacgccta agtcaagtgc gctttggctt 2346961 gtccattttc ctgttccttt ttggcctgct ttatcaagaa tcacatcaac aagcggtttg 2347021 cctgtttctt cgtctttttt tgtgaagatg tcagccgtaa tctcaatcag gtagctatca 2347081 agctcacctt tattccattc agcgaaaact tcatgaagct catcagcaga aaggcccagc 2347141 acctgtttca gaatgaaata tgattcagag atcagctgca tatctccgta ttcaattccg 2347201 ttgtgcacca tttttacgta atggccggcg ccgtccggac cgatatatgt cgtacaaggt 2347261 tctccgtcaa cttttgcaga aatggcttca agaatcggtt ttacaagctc atgtgcttct 2347321 ttttgtccgc caggcatgat agaaggtcct ttaagcgctc cttcttctcc gccggaaacg 2347381 cctgttccga taaaatgaat gccgctttca gcgagttctt tgttacggcg ctgtgtatct 2347441 ttatagtatg tattaccgcc gtcaattaaa atatcatcct tctctagatg aggaagaaga 2347501 gattgaattg tcgcatctgt tgcagttccc gctttaacca ttaataagat tttgcgcggt 2347561 gtttccaagg attggacaaa ttcttcaatg ctgtaagtgc caacaacatt ttttcctttt 2347621 gcctcctgta aaaactcctc agttttactg cttgatctgt tgtaaacaga aacagaaaat 2347681 ccccggcttt cgatatttaa agccagattt ttacccatga ccgcaagtcc gataacgccg 2347741 atttgttgtt ttgacatatt ctaacgtccc ttctgcaaac gtttaatcat tttaaaattt 2347801 aaattaaaat aaaatgatat ttataataaa gaaattacca tacattcacc ctttttttca 2347861 agcgattcag cttttctttt catcttgaaa aaaatcttta ttaaagcttg ttccctttgt 2347921 tttgctctcc tcttttttta acgttgcccc ttttctgatc agtttggtac cgtacttttt 2347981 attcagcttt tccatcatct gctgaatggg ctcatccttc gcatcttcat taaagctgaa 2348041 caaatcgagc tgtttatagg cctgctcttt ttctactaaa tccgttccgg taatgccaag 2348101 cagcctgaca ggatttttat tccaatgttt aaaaaagagg tgctccgctt ctttcaaaat 2348161 gtcatttttt tgatcaatcg ggtttctcag cgtagtgctt cttgtgatgg ttctccaatc 2348221 cgcatatcta atcataataa aaagcttcga agccatgact tccttgcgct gtaaacggtc 2348281 actcacagaa gcggcaagct ttctaaaaac gcctaacagc tcttcttcat cactggaatc 2348341 atgggaaagt gtcgatgagt tgccgacgct tttaaattcg taaatgcgct ccgggtcaac 2348401 cggcgcatgg tgaatgccat ttgctttatt tttaaggcgc ggaccgttga tgccaagcag 2348461 gcgcttcagc gagtgttcat cagctgcagc tagctctccg attgtatgga tgccgagtcc 2348521 cttcagtttt tccgctgtct ttttgccgac tccgtgcatc tctccaacag gaagcggcca 2348581 caggatatcg ggcacttgcc tctttcttaa gatcgtaatt ccaagcggtt ttttcatatc 2348641 agacgccatc ttagcgagaa atttattcgg tgcaatccct atgcttgacg ggagcagcag 2348701 ctctttttgc agcctgcttt ggatttcttt tgccgtctct agagcgcggc tgctgtatgg 2348761 tgtatcggtc atgtccatat agccttcgtc gatggagaca ggctccacta ggtcagtata 2348821 ttcacgaaga atggtaaaca tcgctcgtga agagtttcta tagcggtcaa agttcggcgg 2348881 aagaacgatg agctcaggac aatggcgctt cgcttgccaa accggcatcg ttgttttgac 2348941 gccgcgcgct cttgcttcgt agctgcatgt taccacaatg ccctttcgct cctttacgtt 2349001 tccggcaact gcgaccggct ttccccggag agccggatca tatgccattt caaccgacgc 2349061 ataaaagcta ttcatatcaa tatggaaaat aattcggctc tttcccggca taaacaaatc 2349121 tccttttcgg tcattagaca acagcttgta catatagtaa aatgaagcta ttgaatggat 2349181 gtgatgacaa tgtttgtgga atcgataaat gacgttttat tcttagtcga ttttttcaca 2349241 attattcttc ctgctctaac ggcaatcggg attgcattcc tcttacggga gtgccgtgcg 2349301 ggcgagcaat ggaaatcaaa acgaacagat gaacatcaga cggtctttca cattaaccga 2349361 acagactttc ttattattat atatcatcgc attacaactt ggatacgtaa agtcttccgc 2349421 atgaattcgc ctgtgaacga tgaggaagac gccggttctc ttcttttata aaccgcattt 2349481 ataaaaagga ggagaacaaa attgttaaaa acatatcaaa aacttttggc tatgggtatc 2349541 tttttgatcg tattatgctc gggcaatgct gcatttgcag cgactaatca ggtgggaggc 2349601 ctcagcaacg taggtttttt ccacgattat ttaatcgaac cgttttccgc tctgcttaag 2349661 ggtgttgccg ggctgtttca cggagaatac ggactctcta ttatcctcgt aaccattatt 2349721 gtgcgtatag ttgtattgcc tttgtttgtc aatcagttca aaaaacagcg catcttccaa 2349781 gagaaaatgg ccgttattaa acctcaggtt gacagtatcc aggttaagtt gaaaaagacg 2349841 aaggacccgg aaaagcaaaa agagctgcaa atggaaatga tgaagctgta tcaggagcat 2349901 aatatcaacc cgcttgcgat gggctgtctt ccaatgctga ttcagtctcc gattatgatt 2349961 gggctttatt acgcgattcg ctcaacacct gaaattgcgt cacactcgtt tctatggttc 2350021 agtttagggc aatctgatat tctcatgtcc cttagtgcag ggattatgta ttttgtccaa 2350081 gcctatatcg ctcaaaaact gagcgcgaaa tattccgctg tcccgcaaaa ccctgcagcg 2350141 cagcaatccg caaaattgat ggtgttcatc ttccctgtga tgatgacgat tttctcgctt 2350201 aatgtgccgg cagcccttcc gctgtactgg tttacaagcg gactgttttt gacagtgcaa 2350261 aacatcgtcc ttcagatgac gcatcataaa agtaaaaaaa cagccgctct tactgagtcg 2350321 gtgaaataaa aaagcaaccc cgtgcaaaaa gccggggttg ttttttgtta cttgcaaagt 2350381 accgcgccaa acagtcttgt ttatcatggc tgaagcagaa atggccatcc taaaaaatag 2350441 ccgtatcgtt taaaaagaag gaaatcggga atacctttac tcacctccaa ccgaaaggag 2350501 cctatacgtt gacggaacgc tttcagcaaa aaaatatttc tgtacctgat ggaatctgga 2350561 tcatgagaca aacctggaat gatgtcttat ttgctcactg gcctgttgat gtttctatcc 2350621 ttcgcgcttt ggtaccgtcc gttttagaat tagatacata taacgggcaa gcttggatca 2350681 gcatgcttcc ctttatgctc acgaacctga gggcgcgtta tctccctgtc attcccggtg 2350741 cgcgtgcatt tcctgagctt aacctccgca cctatgtcac gtataaaggc aagcccggca 2350801 tttatttttt tagcttagat gccgatcatc gtctggcggt ccttggcgct cgcacattct 2350861 ttcatctgcc ttatttttac gcggatatga agtccgaaaa aaacggtgat gccattgact 2350921 atgtcagcaa gcggaaaaat gacaaagaag cagcattcca cgccgcatac cggccaattt 2350981 cagcgccttt tacagcagaa aaggattcgc tcgattactg gctgacagaa cgatacaggc 2351041 tctacaccac ttatcgcaat aagctctatt acgaagacat ccatcatcat ccgtggctgc 2351101 tgcaaaacgc cgaagcagaa atttcagtca atacggtgac tgatgctcac ggtattacat 2351161 tgccggagtc agaccccttg cttcattatg ctaaaaaaca ggatgtgtta ttttggccgc 2351221 ttaggaaatg gagctaaaaa aacccgatgc gggaaatcgc actcgggttt tcttttttta 2351281 ttttgccgcc tcttcaataa tggcaacaac catttctgcc gttttaacga gctcttcgat 2351341 cggcattttt tcattttttg tatggatttg ctcataaccg acagcaagat tgaccgtcgg 2351401 gatgccatga ccagcgatta cgttcgcgtc gcttccgccg ccgctcgttt gcagctcgct 2351461 tggacgtccg attttagcag ccgctttttt cgcgatttca acaacttggt cgccgtcttg 2351521 atatttaaag cccggataca taacctcaat ttcgacttct gcgcgtccgc ccatatcagc 2351581 agctgcctct tcaaaagcag ctttcatttt ttgaacctga gcttccattt tctcaggaac 2351641 taaagagcgc gcttcagcaa gaatatgaac ttcgtcgcac acaatgtttg tttgtgtgcc 2351701 gccttcaaac cggccgatat tagctgttgt ttcttcatcg atacggccca atggcatttt 2351761 tgagatggct ttgctagcga ttgtaatcgc tgaaatgcct ttttcaggtt caaccccggc 2351821 gtgagcggtt ttcccgaaaa ttgccgctct taccttcgcc tgtgtcggcg cggccacaat 2351881 gatatttccg acttttccgt ctgaatcaag agcatagccg taggatgcag tgatcataga 2351941 acggtcaagc gccttcgctc cgatcagacc cgattcttcc cctactgtga tgatgaattc 2352001 aatcgtgccg tgttcaatat tttcttcttt cagcacctta atcgcctcaa acattgcagc 2352061 caatcccgct ttatcatcag cacctaaaat cgtcgtgccg tcagttttga cgtaaccgtt 2352121 ctctacaact ggttttacgc cgtttccggg tacaactgtg tccatatgag atgtaaaata 2352181 gatcgtatct gtttgttttg tcccttttag cgtgcaaatc aggttaccgg ctccgtggcc 2352241 cgtgatatcc attgtatcgt cttctttaac gtccacacct aaatcagaaa attttcgttt 2352301 cagcactttg cagatttcag cttcgtgctt tgtttctgag tcaatttgga caagctctaa 2352361 aaattcttcc agcaggcgtt tttcattcac catttgtaag tccctccata ttaaagcggt 2352421 atgttaccgt gctttttttt cggtctctct tctgtcttat gtgtaagcat atgaaaagct 2352481 tgaatcagtc ttccccttga ttcttccggc aaaatgatgt catcgaccat tccacaagcg 2352541 gccgctttgt atgggccggc gttttgcttt ttgtattcag cagttttttc gcgtttcgtc 2352601 ttttgcgggt cagctgaagc tttgatttcc ttttcataca aaatcgatgc cgcaccttct 2352661 ggacccatca ctgcgatttc agcattcggc catgcaaaca caaggtccgc tccgatcgct 2352721 ttgctgttca tggccacata ggcgccgccg tacgcttttc taatgatgag tgtgactttt 2352781 gggacagtcg cttcagcata agcaaacaat aattttgctc catgcctgat gattccgttg 2352841 tgctcttgct gaatacccgg cagaaacccc gggacatctt cgacagtcaa cagcgggata 2352901 tcaaatgcgt cacaaaaacg gatgaacctt gctgctttat cagcagcgtc aatcgtcagg 2352961 cttcccgcca gatgcttcgg ctggctcgcc acgatgccga ttgctttttc acccagcctt 2353021 gcaaacccaa tgacaatgtt cttcgcaaaa aatggctgaa tctcaaaaaa agactgcggg 2353081 tcagccagct ccctaatcac cttccgaaca tcataaggct ttgtcgtatc agcagggaca 2353141 agacggttta ataacggtct ggacgcctct ttctctggct tcggctctgt tgtccggcca 2353201 ttcagcggca aataagacag tagttttctc acccctgtca gaacctcctt ctccgtatgc 2353261 ccggaaaagt gggcgtttcc gctgacggca ttatgtatcc ccgctccgcc taagctctcc 2353321 gcatcaacct gttcccctgt cactttttca atcaccttcg ggccggtaat aaacatccgg 2353381 ccagtctgtt cagccataaa tataaaatct gtgagtgccg gagaatatac agcgcctcca 2353441 gcgcacggcc ctaaaataac cgatatttgc ggaatgactc cggaatataa gacgtttcgg 2353501 taaaatatgt gaccgtatcc atctaatgat aacacaccct cttgaattct cgcaccacct 2353561 gagtcattca gcccgataat cggcgcctta ttttttgctg ccagatccat caaagcgcag 2353621 attttcctgg catgggtttc gccaagcgcc cctccgtaca ctgtgaagtc ttgcgcaaat 2353681 acataaactg agcgaccgtc aattgtgccg taccctgtca cgaccccatc ccctaacatg 2353741 cgctgttctc ttgttaacac ttgactttcc atgaaggggt gtaattcgat aaagctgtcc 2353801 tgatctagaa gaaatatgat cctttcccga gcagtgagct tgcccttttg ccgctgctga 2353861 gccagctttt cccgtcctcc gccttcttct gcctgcttgc gtttcgtgta aaaatgatcc 2353921 atgtgctcat tcatgctcat tgtgttggtc tcctttcggt tcacaaagct ctacaagaac 2353981 accgtttgtt tcccgagggg aaataaacgc gatctttttc ccgttcgctc cctgtcttgg 2354041 aaacctgtca atcaattgaa catgctgatc agacaatgct tgaagctgtt cagataggca 2354101 gttgcacaaa aacgcaatat gatgcagtcc ctgccctttc ttctccaaaa ataaatggac 2354161 ggggctgtca gctgtcaacg gctctatcag ctcaagtttg acgctaccag cttgaaaaaa 2354221 agcaacattc accttttgct cttcaaccgt ttcttgatga agaaatgcaa gccccaatac 2354281 attttcataa aagcttcttg catcttttat cgaaaaaacg gctatcccga tatggtcaag 2354341 cctgttcatt ttcatccctg ctttcgctaa tagatatcgc ttgtccgccc attcaaaaca 2354401 cgctaaaata tagacagatt gtttaaggag tgaaaatcat gtctcaaaaa ctgatgaaaa 2354461 gcgttttgat cgtgattttg ggagttttta ttctttcaac tgtactctca ggaatcgtca 2354521 tgtttctata acgataaaaa agcaggcgcc ttattcaatg ggaatatcct gcttttttat 2354581 cagagcttta tgctcgatgg caatctcctc aaaagagcgg ttgtcgtccg tgatcagcac 2354641 tctcgttcct actggtatcg tttgaaacaa atgaacaacc tcatcgttat gcatacgtat 2354701 acagccgtta gacacaaatt ttcctactga ttcctctcgg tttgtcccat gaattccata 2354761 aatccgcccg tccgttcctt tcgcgtcaaa tccgatccat cttgccccaa gcgggttatc 2354821 aggagatccc ccttcaatat ttttctttct gtagtaagga ttttccgctt ttaccgttac 2354881 cgaaaactct ccttcaggcg tcaaatcatc tgtttttcca gtcgccacac tatacacgcc 2354941 ttctactttg ttgtcgagga taacagcaag ttcatttgtt cgcttgttga caataacata 2355001 cggatcaccc ggcagcggat tttcgccgag cggccaaatc ggtgaaatca tcatgaaaat 2355061 cgaacataag aaaaaacgca taagctcctc ctttttcatt aggttgacca atgaaggaag 2355121 agctcatgcg aatcatccga gtgatttttg cgcttttatt cctttaaaat aacttttaat 2355181 cactaaatat tgttccattt cgccgagaag atggaagaga gcggccctcg cttcaaattc 2355241 ctctctagtc gcaggaagcg gcatctcctc aaattctttt ctcatgtcag caagtctttt 2355301 cagaaatttg tatgctgtat tcccagggtg tatcgcctcc cgcaaatcat gaataaattc 2355361 agcgatcatt tttccctgat ctaccgtgat ggagatcgat gtcactttag ggagaaggcg 2355421 ttcgataatt tcaaattgct tttctctcat tttaaaataa tgataatgca gattttcata 2355481 acgcaaaatg tggttttgca catctcgata tgccaggttt ttagcctccg taatgagctg 2355541 gtgcgtttcc ggaatttctt ttcctgacca atcttgctca ccagttaaca aataccgttc 2355601 gatttctgca aaaatgacag caaagttatc ctctatcttt ttgcggtagg caatcagttt 2355661 ccggtcaaga ctaggcatat acaagttcat caatagagcg acgccgatgc caaccgtaat 2355721 cagctgaact tcattccaga tgaaagtagg cgtaatgccg ccggacatgt ataaatgaag 2355781 gataataaca gaactggtga cgataccctc gttaattttt aacagaaccg ttatcggaat 2355841 gaatatcaaa agaagcgctc cgatcacaaa cgggtggtag ccaataagct cgaaaaagag 2355901 ataagaaaaa gcaattgcca gacagcatgc cgaaaagcgg gcccatgagg cctgaagcga 2355961 ccgtttttgt gtgatttgta tgcacaaaat ggtgatgatt cctgctgatg cgaagttttg 2356021 caaatgcaat aactggctta tataaatagc caaagctgtt ccaagcgcgg tctttattgt 2356081 gcggtaacca attttaaaca tgtcggactc catttctatt tgtttcttca ataaaaaaga 2356141 agaggcggcc agccttcttc ttttttatat tctataatat tttctctaaa aagtcctgcg 2356201 ctcttttgga ttttggcgac ataaaaaatt ccttcggatt gccgtcttcg acaatcattc 2356261 cttggtccat aaacagcaca cggtctgcca cttcttttgc gaagcccatt tcatgtgtga 2356321 caatcaccat ggtcatgccg gtttcgacca gctctttcat cacctgtagc acttctttga 2356381 ccatctctgg atcaagggcg gaggtcggct cgtcaaacag catgatgtcc ggattcatcg 2356441 caagagccct ggcaatcgcg acacgctgtt tttgtccgcc agacaaacgg tttggatagt 2356501 catttcgctt ttcaaacaaa ccgactttgc ggagcaggtc ctcagctttc tcctgtgcag 2356561 cctgttttga ttcttttttt acattgacag gcgcgtacat gatgttttcg agaaccgttt 2356621 tgtgcggaaa gagatgaaaa tgctgaaaaa ccatcccgat gttttcccgg acctttaatg 2356681 tgttggtttt cggcttcgta atctctgtgt cttttattgt aatggttccg ccgttaggct 2356741 tttccaacag gtttaaacag cgtaagaacg ttgatttgcc tgagcctgaa ggaccgatca 2356801 cggcaacaac ctcaccctca gcgattgttg ttgaaatgtt ttttaatact tcgtgtttcc 2356861 caaatgattt tgacagcttt tcaaccttaa tcattggatt tcagcttcct ttctacagcc 2356921 ttgccgataa acgttaaaat caggacaagc acataataaa tcaatcccgc gataatgagc 2356981 ggctcaaggt aattgtaagt ggcggcgcca gcttgatatg cgcgtctcat gacatcacca 2357041 agcccgatga cggtgacgat cgccgattct tttgttaacg taattaattc attcacaatt 2357101 gcaggtgata tatttttgaa ggcctgcggc agcagcagat ccttcatcat ttttccatac 2357161 gggacaccga gtgcaacagc agcttctttt tgccctttat caatggcatt gattccggct 2357221 ctgataattt ccgatacata agcggcggaa ttcaaagaca atgcgacaac cgcagcccaa 2357281 aactggtcaa tttgaaatcc gagcagctga ggaaggccaa aatagacaat cataagctgc 2357341 agcactaaag gcgtgcctcg gaacactgat gtataaaaat cagcgatcca gataaacggg 2357401 cggaatgtgc tgatcttgca taagcttagc acaataccga gtataagtcc gataatagca 2357461 gatacaacaa caatttttaa tgtaattgcc aagccttcta atataaaagg aatttggggg 2357521 atcgttgctg aaaaatccaa attcatagcc tttgtctcct tttcttacag gaaaaaagtt 2357581 tcctattcaa taaaaaggct caacgaaaaa gttgagccgc ttttttttac ttctcgccag 2357641 tgaaccattt tttcttcaat ttctcaagct ctccgttatc ttccatttcc ttgagcgctt 2357701 tattgaattt gtctgtcagt tcactgtcct ttctgaaagc aattgctgaa ccggcttctt 2357761 ccgctttcgc atcaggaatc acaaagcctt gcaggtcatc atttgatttg aaataccctt 2357821 ctgcaacaat gtcttcaata atcgcggcat cgaagcggtc agatttgatt tcctgcacca 2357881 aatcagaaat tctgttgcgg tcttctgttt taaaaccata ttccggagaa agctctttcc 2357941 ccttctcttc ctgaatagag ccaagctgaa cgccaactgt ttttcctttc aggtctttca 2358001 aagattgaat gccgctgtct tttttgctga caatcatatg gttcgctgtg taatacacat 2358061 cggaaaaatc aacttgtttt ttacgctcag gcgttggtgt cattcctgac agaacgagat 2358121 ccacctgttt tgatttaagc gctgtaatta agctgttgaa gtccatatcc tgcacttcaa 2358181 tttcatagcc tgccttcttt gccagagctt ttgccagctc tacatcaaag ccgacaatat 2358241 tatctccttc tttatattca aacggtttgt aatccgccga agtacccata attaattttt 2358301 tctttccgct ttctgaacct gaattgcttg agccgcacgc agttaatgca aaggtgatgc 2358361 aagcagccac aagtaataag agccattttt tcatgatcca tttcccccgt attcattact 2358421 tttggtgtat ttgaatattt attcgttaat ttgtatttta aacagtttct catttttatg 2358481 caatactatt tttaaaaatt atctttaggc ttatctttcc agtgatctct tctgatatta 2358541 ctagataaaa attaaatcgc tgtacaatcc gattgaataa tcccttaata tttattcata 2358601 tatccttgga aatttatgca caaaaaaacc cgggctgctt tgagcatccg ggttgttcgt 2358661 cttatacttc ttcacaatat tcttcaaagg cttcctgcag ctttgccact acagccatcg 2358721 gctcatggcc ttcaatttca tgacgctcta ccattttcat gatctttccg tctttcaaaa 2358781 tcgcaaagga cggagaagat ggtggataac cttcaaaata gtcacgcgca cgcgctgtcg 2358841 cttctttatc ctgtccggca aaaacggtga cgagctgatc aggtctttta tcatagtgaa 2358901 cggaatggta ggctgccggt cttgcaattc ctccggcgca tccgcaaaca gagtttacca 2358961 tgacgagcgt cgttcctttt ttcgtaagtg cctcatccac ctcttcggct gttttaagct 2359021 cggtgtatcc ggcagctgtt atttcttgtc tcgcttggcg gacaatatca ttcataaata 2359081 aattaaagtc catgttcaat gaagacctct cctttttcat catctgttct tatgatagca 2359141 aggaaacgtc catatcggca aatgactttg cttcgccgtg cacttttttt gctcttcgtt 2359201 tactgcttac agaaaaaggg gattatataa ccagaagtaa aataaaggag cagttgtata 2359261 tgagccaccg gaaagcgtta ctgattcata acggaaatgc cggcaacaaa aatatagaaa 2359321 aagcacttgg tgctgtggtg ccggttttat ctcaccattt agatgaggtg attattaaac 2359381 agacaaagaa aaaggatgat gcgtatcatt tttgccgatc cattgatgat tctgtcgaca 2359441 ccgtcttcat tctcggcggc gacggcacga tccatcaatg cataaatgct atcagcgctc 2359501 tagaaagaaa acccgctgtc ggaattttgc ccggcggcac gtgcaacgac ttttcaagag 2359561 tgcttggcat ccctcaaaat cttgcaaagg ccgcggaagc acttatggcg ggaaaaaaaa 2359621 ccagcgtaga cgtatgtcag atgaatgacc gttatttttt gaatttctgg gggatcggct 2359681 taattgcaga aacgtcgaat caaatcaacg aaacggaaaa agcattattg ggaaaaatca 2359741 gctattttac aagtgccttg cgaaccgtct catctgctgc atcgtttccg atgacattaa 2359801 aaattgatgg agaagaaatt aaagaagaag ccgttatgct gcttgtgatg aatggccaat 2359861 acattggaac gaatcgaatt cctctgcccg atgccagtat tgaagacggc ttacttgatg 2359921 ttctcatatg ccgcaatacc aacctcaccg cgctgcggga gctgatgagc atggaacaag 2359981 gctcaattga tcgttttact ggagagttgt cctatgtcca ggcttcccgt atcgagattg 2360041 aaacagacac tgccaaaaag gcggatatgg atggagaagt ttatacacat acacccgcag 2360101 tcattcaggt cctgccacag catatcgaca tgcttgttcc cgcaaatgaa taactgtcat 2360161 aaggctttag aaagattttg caaatccgtt gactctcccc taggaggagg tcttacagta 2360221 taagggatac acacttgaaa aaggggaagt catatggaga agaaaaatat taccttaact 2360281 atattattaa ccaatttatt tattgctttt ttggggatcg ggcttgtgat tccagtaacg 2360341 ccgaccatta tgaatgaatt gcatttatcg gggaccgcgg tcggctatat ggttgcctgc 2360401 ttcgctatta cacagctcat tgtctcacca atagccggac gatgggttga tcgcttcggg 2360461 cgcaagatca tgatcgtaat cggcctgttg ttctttagtg tgtcggagtt tttgttcggc 2360521 attggaaaaa cagttgagat gttatttatc tcccgtatgc tgggcggtat cagcgcagcc 2360581 ttcattatgc ccggggtcac ggcttttatt gcagatatca cgaccattaa aacacggcca 2360641 aaagcgctcg gttatatgtc agccgctatt tcaacaggat ttattatcgg ccccggcatc 2360701 gggggatttt tagcagaagt ccattcccgg ctgccttttt tctttgcggc agcttttgca 2360761 ctgttagcag ccattttatc aatcctcacg ctgcgcgagc cggaacgaaa ccctgaaaat 2360821 caggaaataa aaggacagaa gacaggcttt aaacgaattt ttgcccccat gtatttcata 2360881 gcttttctca ttatcttaat ttcgtctttt ggtttagcat catttgaatc tttatttgca 2360941 ttattcgtgg atcataaatt cggatttacg gccagcgaca ttgccattat gattacagga 2361001 ggagcgattg ttggcgccat tacgcaagtc gtcttattcg accgcttcac aagatggttt 2361061 ggcgaaattc atttaattcg gtacagctta attctctcga cgagtctggt attcttgctg 2361121 acaacggtac attcatatgt tgcgattctg ctggtgacag tcaccgtatt tgtcggattt 2361181 gatctcatgc ggcctgcggt aacgacttac ctgtcaaaga ttgcgggaaa tgaacagggg 2361241 tttgccggcg gtatgaattc aatgtttaca agtatcggca atgtattcgg gcctattatc 2361301 ggcggaatgc tgttcgatat agatgtaaac tatcctttct actttgcaac ggtcacctta 2361361 gccataggga ttgcactgac cattgcttgg aaagcgcctg cacatcttaa agccagcacg 2361421 tgataagaag cgcattcttt gtgtactgca aagaatgcgc ttcttcttta tactgatgat 2361481 agaaggagtg atggcatgaa ggaatcgtat tactcaattg gggaagtatc aaaactggca 2361541 aacgtgtcga taaaagcgct ccgttattac gataaaattg atttatttaa accagcctac 2361601 gtcgacccgg ataccagcta ccgctattat acagattctc agctcattca tctggatttg 2361661 atcaaatcat tgaaatatat cggcacacct ttagaagaga tgaaaaaagc acaggactta 2361721 gagatggaag aactgtttgc tttttataca gagcaggaga ggcaaatcag ggagaaatta 2361781 gactttttat cagccctgga gcaaaccatt tcattggtga aaaagcggat gaaacggcag 2361841 atggaatatc ccgcgctcgg tgaggtgttt gttttagatg aagaagaaat acggatcatt 2361901 cagacagagg cagaaggaat cgggcctgaa aacgtgctca acgcctccta cagcaaatta 2361961 aaaaaattta tcgagtcagc agatggattt acgaacaata gctacggcgc tactttctct 2362021 tttcagccct acaccagcat tgatgaaatg acttaccgtc atattttcac acctgtattg 2362081 acgaataaac agatttcatc aattacgccg gatatggaaa tcacaacgat ccctaaaggg 2362141 aggtatgcgt gtatcgcgta taatttttcg cctgaacatt attttctcaa cttacagaag 2362201 cttatcaaat atatcgcgga ccgccaatta acagttgtca gtgatgtata cgagttaatc 2362261 ataccgattc attactcccc gaaaaaacaa gaagaatatc gagtcgaaat gaaaatacgg 2362321 atcgctgaat aataaagcat agaaaaagag cattttttga aacaaaactt caaaaaatgc 2362381 tctttttgct tatttagtaa acagatgtct tctcgtcaat cgattctaaa atttgtttca 2362441 ctcgtccgag gaatcgtccg cacacgagac cgtcaagcac tctgtgatct aatgacaggc 2362501 acagattaac catgtctctg acagcaatca tgccattgtc catgacaacc gggcgtttga 2362561 cgatggattc tacttgaaga atcgcagcct gagggtagtt gataatgccc atcgactgaa 2362621 cagacccgaa cgaacctgtg ttgttgacgg taaacgtgcc tccctgcatg tcatctgcag 2362681 tgagttttcc gtctcttact tttttagcta ggccggtaat gtctttcgca atgcctttaa 2362741 ttgttttttc atcagcgttt ttaatcaccg gaacaaataa agaatcctct gtggcaactg 2362801 caattgaaat attgatatcc tttttctgaa taattttgtc ccccgcccac atgctattca 2362861 tttgcgggaa ttcttttaac gcctgagcga ccgcttttac aaaaaaggcg aagaacgtta 2362921 aattaaagcc ttctgtcttc ttaaaagaat cttttatact gttgcgatat gcaaccatat 2362981 ttgtgacgtc gacttccatc atcgtccaag catgcggaat ttctgttttg cttcgcttca 2363041 tattggaagc aattgctttt cttacacctg tgacagggat ttctttatca ccggctgcag 2363101 acgcaggata tgacgtctct tcttttggct caggttttga tgcagacttc ggtgcaggag 2363161 ctgctgtttt cagctcctca ggattctgtt cttgcacgcc gcctgtttca attaagcgct 2363221 gaatatcttt tcgtgtgatg cgcccgccgg caccagttcc tgtcacttga tcgaggtcaa 2363281 tgccgtgctc tccggccaaa cggagaacag ctggcgagta gcgcttttta ttgggctgat 2363341 cggctgctcc agcacttttt gcaacagggt tctcagcggc ttctgatgct gctggctgtt 2363401 cttgtttttg ttcagccgga ttcgcgcctt ctgtttcaat tttgcaaatc atttctccga 2363461 cttgcagggt ttggccttct tctcccacaa gctctgttat cgtaccagta aaagaagacg 2363521 gaacctctgc atttacctta tctgtcatga cttccgcgat cggatcgtat ttgttcactt 2363581 tatcaccggg ggcgacaagc catttgctga tcgtcccctc tgttacgctt tctccaagct 2363641 gcggcatcgt catttgttca attgccatga ttgtatcctc ccttacgtct ttaaaactcc 2363701 gctaattctc tcatcgccgc ttccacttta tcagggttga ccataaagta tttttccatt 2363761 gtcggcgcat aaggcatagc cggaatatca ggacctgcaa gccgtttgat cggcgcgtct 2363821 aagtcgaaca gacaatgctc ggatataatt gcggctactt cgctcatgat gctgccttct 2363881 tttgtatctt ctgtgaccaa aagaaccttt ccagttttgg acgcagcttc gatgatggct 2363941 tctttatcaa gcgggtaaac tgttcttaaa tccaccacat gcgctgaaat gccatctttt 2364001 tcgagacgtt ctgcagcttg taaggcgaag tggacacaca ggccgtatgt gatcactgtg 2364061 atgtcgtcgc cttccctttt tacgtccgcc ttgccgattg gcaggacata atcatcagcc 2364121 ggaacctcgc cctttatcag acggtatgcc cgcttgtgct caaaaaacag cacggggtct 2364181 tcgtcacgaa ctgcggcttt taagagccct ttcgcgtcat atggtgttga tggcatgaca 2364241 attttcagtc cgggctggtt ggcgaaaatt gcttcgactg attgagaatg atacagggct 2364301 ccgtgcacgc ctccgccgta tggcgctctg acgacaatcg gacagctcca gtcattgttg 2364361 ctgcggtagc ggattttagc cgcttcagaa ataatttggt tgactgccgg cataatgaaa 2364421 tcagcaaact gcatttcagc aatcggtctc attccgtaca ttgccgctcc gataccgact 2364481 cctgcgattg cagattcagc aagcggcgta tccataacgc gctcttcccc aaattgttca 2364541 tagagtcccg ctgtcgcttt aaacacaccg ccttttcttc ctacatcttc cccaaggacg 2364601 aaaacgcgag aatctcgttc catttcttct ttcatcgcca aattgattgc atcaatatat 2364661 gacattactg acatttgttc ttcctcccta cttcgcataa acataatcaa gcgctgactc 2364721 aggagctgca tatggggcgt tctccgcttc atccgtcgct tcatttacga ttgccataat 2364781 ttcatccagc atggtttgtt ctatctcatc ggacagcagg cctgtttcct ttaagtaagc 2364841 ttgataagta agcaggggat cacttttttt cgcttcctct acttcttcac ggcctctgta 2364901 gctgctgtca tcgtcatcac tggaatgtgg tgtaaggcgg taagaaatcg tttcaattaa 2364961 tgtcgggcct tctcctctgc gtgccctttc gcgtgcttct ttaaccgctt gataaacttc 2365021 cagcggatca tttccattca cagttacgcc aggcatccca tagcctatgg cacggtcgga 2365081 aatgttctca catgcgactt gcttatcgta aggcactgag attgcgtatt tgttgttttc 2365141 acacatgaaa ataaccggca gcttatggac agcggcaaag tttgcccctt catggaaatc 2365201 gccttggttt gaagaccctt ccccgaatgt aacaaaggct gcgatatcct ttttctccat 2365261 acgtcccgca agcgcaatac cgactgcgtg cggcacttgc gttgtaaccg gagatgatcc 2365321 cgtcacaatg cggtttttct tttgtccgaa atgtcccggc atctggcggc ctcctgagtt 2365381 cggatctgct gcttttgcaa acccggacat cattaagtcc tttgctgtca tgccaaacgc 2365441 gagcacgaca cccatgtctc tgtagtacgg caatacataa tccatttcac ggtcaagtgc 2365501 gaaagccgct cctacctgtg ctgcttcctg tccttgacaa gagattacaa atggaatttt 2365561 gccagaacgg tttaacagcc acattctttc atcgattttt cttgctaaca gcatggttct 2365621 atacatatca acggcttcct gatcagtcag ccctagtgct tgatgtcggt ttgtactcat 2365681 tcaagcccct cctttatgct tttaaaaatg aatggctttg ccatctgcgg caagcgcagc 2365741 ttctccaatt gcttcagaaa gcgttggatg cgggtgaatc gtttgcccga cctcccacgg 2365801 tgttgcgtcc agcactttgg caagacccgc ttcagaaatc atgtcggtga catgcgggcc 2365861 aatcatatga acgccgagaa tatcatctgt atctcggtca gccacgattt tgacaaaacc 2365921 gtcgctttca ccgtatacaa gcgcttttcc aatcgccata aatgggaact tgccgatttt 2365981 gacattatgc ccgttcgcct ttgcttcgtc ttcggttaag ccgacactgg cagcttcagg 2366041 gcttgagtaa atgcacttcg gcacaagcgt cggatcaagc ggatgcggat tgagacctgc 2366101 aaaatgctca acagcaataa ttccctcatg tgaagcaacg tgagctaact gcaggccacc 2366161 gattacgtct ccgattgcat aaatatgaga ttccttcgtt tggcagcttt cattgactga 2366221 aatcatgcca ttttcagtaa caatatcggt gttctctagg ccgatgcctt cgatatttgc 2366281 ctgtctgccg atggaaacaa gcattttctc agcagaatag gtaacggttt ctccgtcttt 2366341 ttccgcttgt atgctgatat cgtctgatgt ttttgtcatt gtgtcaggca gcacttttgc 2366401 ccctgttatg aactggatgc cttttttctt aagaagactt tccatttctt ttgaaatctc 2366461 tagatcttca gtcggcaata tgcgatccgc gtattcaata accgttacct taacgccaaa 2366521 atcatgaagc atagacgccc attcgatacc gataacccct ccgccgacaa tgatgattga 2366581 ctgtggcagc tcctccattt ggagcgcctc atctgaagtc agtacagact taccgtccac 2366641 ttcaagaccc ggaagcattc tcggtcttga tcctgttgca atgatcactt gtttcgggat 2366701 cagcatgtca ttttcttcgc catttccccg ctcaacagaa attgttcccg gcagcggaga 2366761 gaagattgac ggtccaagga tacgtccata tccggtgtac acgtcaattt ttcctttttt 2366821 cattaaatga tttacacccg ctgcaagctt atcaacaacg gcttgcttac gctgctgcac 2366881 tttttcaaag ttgagggaca cgccagccgt ttccactccg aattgatcgg cttcacgagc 2366941 tgtccggtat acctctgcgc ttctaagcag cgctttactc gggatacagc ctttatgcag 2367001 acatgttccc ccgagttttt ccttttccac aacggctgtt tttaagccga gctgagcggc 2367061 tctgatggcc gcaacataac cgccggtacc gccgcccaga atgactacgt catactcagt 2367121 tgccatggtg actcactcct gtctgtctat tcaatacgat attgtttgga ttgctcttcg 2367181 ccctgcaata ctcttagcgc cccttgggca agagactgca gttcattttc acccggataa 2367241 actaaaacgt ctgaaatcca atctatgtat gatctgatag cagaaacaaa gctttttccg 2367301 tacgcaaggc ctcccgtcag cacaatcgct tcaacttcgc cttttaacgc cgcgctggct 2367361 gccccgattt cctttgctac ctgatatgcc atggcatcat aaatgaagcg ggctttttca 2367421 tcgccccctt gaatcatctg ttccactttt actgcatcat ttgtaccgag atagcctaaa 2367481 agtccgccgg tgccaacaag ctttttcatg atttcttctt ttgtatattc ccctgaaaaa 2367541 catagatcaa caagatctcc cgcaggcact gttcctgctc gttcaggact gaatggtccc 2367601 tcgccgtgca ggccgttatt gacatccacc actcgcccgc ggtcatggac gccaattgta 2367661 atacctccgc ccatatgggt aataatcatt ttcatgttct catatcgttt gccaagggag 2367721 gctgccgctt tacgagcgac agctttttgg tttaacgcat ggaaaatgct tttcctttca 2367781 atttcaggca tgcctgaaac tttcgcaagc actgacattt cgtctacgac aacagggtcg 2367841 acgatatacg aagggatatt caggccgtca gcgatttccc gcgcgataat gccgccgaga 2367901 ttagaagcat gctgaccggc gtagccgctt ttcaaatcct caatcatctc atcattcact 2367961 acgtaggtcc cgccttcaat tggccggaga aggccgcctc ttgcgcagac tgcatcaaac 2368021 tttgaaatat tgattccctg ttcatgaagc gtttcgagaa tatggttttt acgaaattca 2368081 tactgatcaa taattcggtc aaatcgctgc agctcttcta tgttgtgtct caatgttttt 2368141 tcaaaaatgc ttctttcgtt atgaaaaaca ccgattttcg ttgaagttga gcctggatta 2368201 attgtgagaa tgcgtttttc gtcatgtagc actttcataa cctccagatc aatttcttaa 2368261 cgtctgctta atacactgtg gccgttttgc aaaaactggc ttcttgagcg gcgcatgcgt 2368321 tcaatccgtt cctctgctaa gcggtcagcc gctaaatatg caggaatgcc gtcacgctga 2368381 gaaatctcaa gtacacgctc gatattgccg taaatgcctt caactttttt caatgcacgt 2368441 tctgcattat agccgtaaag ctcatctgcc acgttgatga caccgcccgc gttaatcacg 2368501 taatccggtg cataaacgat gcccatttcg tgaatttgat caccatggcg tgtctctttt 2368561 aattggttgt tagccgcacc tgcgatcact ttcgccttca gctgtttaat ggtgtcgtcg 2368621 ttaatagtcg caccaagggc acacggcgca taaatatcgc agtcttgtga ataaatgtca 2368681 tcaggatcta ccgcacgggc gccaaaatct tcaactgcac gctgtacaga ttgtttgttg 2368741 atatccgtaa cgattaagtt tgctccttct tcatgcaggt ggcggcaaag gttataggct 2368801 acgttcccaa caccctgtac agcaatggtt tttccttcaa gagagtcggt tccgaaagca 2368861 gctttagctg ctgccttcat tcctctgtac accccgtacg ctgtgactgg ggacggattt 2368921 ccagaagagc cgaaagcagg agaaatccct gtgacatagt ctgtctcatc atgaatgata 2368981 tccatatcct cgaccgttgt gcccacatct tcagccgtga tgtatctgcc attcagtcct 2369041 tgaatatagc ggccaaacgc gcggaacatt tcctcatttt tgtctttgcg cggatcgccg 2369101 ataatgactg tttttccgcc gccaaggttt aagcctgccg ccgcgttctt ataggtcatg 2369161 cctcttgcca atctgagcgc atcttcaatt gccgcttctt cattttcata tgtccacatt 2369221 ctcgttccgc caagcgccgg accaagcgtt gtatcatgaa tggcgataat cgcttttaat 2369281 ccagattgtt catcctggca gaataccaat tgttcgtaat cgtatttctc catatattta 2369341 aaaagttcca tgttcgttcc tcctaatgtg tgtattcttc agatgcgcat attgccagcg 2369401 caatggaata cagtttattt tcagcagagt ccgctctgct tgttaaagca atcggtgctt 2369461 ttgctcctgt aatgacagcc gccacgctgg ccttggcaaa ataaatcagt gatttatata 2369521 aaatattgcc ggcctcaatt gttgggacga gaaggatatc tgcgttgccc gctacgtctc 2369581 ccgaaatttt tttctgggcc gcggcaattt gtgaaactgc gttatccaaa gcaagcggtc 2369641 catcaacaat gcagcctttg atctggcccc ttttgtacat ttgagctaga gcagctgcat 2369701 tcacggtcgc ttccatttta gggttcaccg tttcgaccgc tgcaagggca gctgcttttg 2369761 gcatattgtt ccccactgca tgggccacat gaacggcatt ttgcaaaatc tgccggagct 2369821 cttccagcga aggagcaata ttcattgccg aatctgtcac aaacatcagc cggtcaaaat 2369881 ccggtatatc gaagacagcc acgtgagaaa ggacacttgc tgaccgaagc ccctcctgtc 2369941 tgttcaatac cgctttaagc aaaacagaag tcggcacatt gcctttcatt aaaacgtccg 2370001 ctgttttatg atgcacagca cgaaccgcta atttcgccga ttcctcagga gtattggcat 2370061 ggacgatttc cacttgatgc ccttgcatgg atgatgtcag ctcgttcagt tttttgctgt 2370121 cgcccgttaa caagaaacgg gcggataggt gctcggctgc cagctttaca gcccggatca 2370181 cttcctcatc ctcagcatga gcaaccgcaa tggtcttatt tttgtgtatc gacgctttgc 2370241 cgattaaatc tttcagcttc atctgttacc acctttcttg tttcgactcc gccttttatt 2370301 atgcaagttc catgccagct cttaagggtg ctgtcatacc aggtataccg aaacattcgt 2370361 gcagatgttt gcgtttattc tgcaaattat tgcatgcctt catttgcaag gccatattta 2370421 tccattttgt aatataaatt ccgaatgctg acaccgagag cttttgctgt ttttgtccgg 2370481 ttaaaatgat gcttttcaag cgtttgctgg atcaaatgcg cttcaaattt ttctactgcg 2370541 acagacagct tttcgccttc aatatccgga aaatcaaaac ctgttccctg atctgtgtca 2370601 ttttcttttt gctcaagttc gaatacaggc aagtgatctt tttcaatcca ttccatatgc 2370661 ggattcagaa aaatcatggc tcgtccaagg acattttcaa gctcccggac attcccaggc 2370721 caatggtagg cagataaggc gcgcaaggct tgctgtgaga gcccttttac attcctgccg 2370781 taatcccggt tgatcttttg gataagtctg acgctcaatg cttcaatgtc ctccaaccgc 2370841 tgccgcaaag gcgggatgga gatcggatag cgattgatcc ggtaatacag gtcttcccgg 2370901 aatgttccgt ccgccatcgc cttttcaata tttacatttg tcgccgcgat cactctgacg 2370961 ttgacaggga tcgctttcgt gccgcccact ctgacgattt ccttttcttg aaggacgcgt 2371021 agcaatttgg cctgcatatt ttgtgtcagc tcaccgattt catctaagaa aatactgccg 2371081 ttatttgctt cctcaaataa acccttttta ccgccgcgct tcgctcctga aaacgcacca 2371141 tcctcatagc cgaacaattc tgattcgagc aggttttcag aaagggctgc acaattcacg 2371201 cgaataaatt tattgtattt ccggtcactt tcgttatgga tggcatgggc gaacagttct 2371261 tttcctgttc ctgattcccc gcgcagcaag atggttgccg gtgttttcgc accgagcttc 2371321 gcctgctcaa gcgcaaccag catttgctcg cttttgccga taatgtcgtc aaacgtgtat 2371381 ttcgcttcaa gcgtgcgaat aatttgtctg gcgcgattaa gctccgctgt cagcatttta 2371441 atttcggaaa catcgtgaat cacgccgacg ctgcctttca aaatcccgtc cacaatcacc 2371501 ggtgctacat taacgatcac ttctttttca ttcgggccga ccttcattct gacaccgcgg 2371561 acaggacgtc ttgtttcaag cacctttaaa tgcatgcttt cgccttcgga aatatcagtg 2371621 tttgcaggct tgccgatgac ttctttttca gaaagccccg tcattttcgt atacgcttta 2371681 ttgattagca ggccgatgcc gttttcatca acgacagaaa tcgcctcatc ggaggattga 2371741 ataattgcct ccagcatcgt acggacctgc tttaagttgg tcacttcctc tgccagctcg 2371801 accgcatcag tgatatcttt aaacacacaa agagccccga gcagacgtcc gccttcatca 2371861 ataatcggca gtcttgtggt cacaatttgc aaatgatcgc ctaacagctg cttctggttg 2371921 tattcaggca ctcttgtttt taaaatccgc ggcatcttag tgctcggaat cacttctttt 2371981 attgggcgcc caatgacttc ctcacgtttt tttccgacca ttttttcggc catatggtta 2372041 aagagaatga tttcttcatt gatatcaata aaaatcattc catcatgggt ggaattaaaa 2372101 attctgtcat atttataggt ttgctctttt agcatttgaa tcaggtgctg cttttcttcc 2372161 atcagctgaa aaacgatgta tgccattttt cccggcatga caatggtatc ttcatgcttt 2372221 ctttgaagga gctcgtcaaa cacggcttga tcgccggtag tatgaatgac gatatccggt 2372281 ttttgttgta tgtaaggttt ccaatcagat gatacggcaa tcccatactg ttctgcttct 2372341 ttcaatcccg gcgcctcggg gtctttgtca actacggcaa tgatatctat gatggctgtt 2372401 ttaatcagaa tatgtaataa cgccgttccc cttttgccgg cacctactat cagtaccttt 2372461 tgcatcccga tacccctttg tatgaaaaaa tttgcacacc tatttattcc gttgcaataa 2372521 tttgcacaac cctatgttac cacgttttct tctcttgaca aaatattttt tccgctggac 2372581 aataaaggaa atgaaaagat aaaggggttt tctgaagatg agccgacttc ttgcgctttt 2372641 aatattagtc atccccgggg ctatttctgc tttaggcatt aaactgatga gagatacact 2372701 tttcggccat acaatcaagc cattttcagc tctttggctc caagggttgt caggattcat 2372761 cttttttgcg atcggcctct atgtgctggc cgggttcatt ttatacagag acagaaaacg 2372821 caatcaagtc agcccgcgat tcagaaaacg atagctgaaa aaaagccgga gaatgctccg 2372881 gctttttttg ttgcattatt cgtcaggcaa aacggtcttg gcaatcgttt tgtctaacgc 2372941 ttcatagtca taataagaaa tcgtatcgta cagttctttt cgtgtctgca tatcatgaag 2373001 tccttctttt tgtgagccgt gctccttcat caaaccaaac atccgctcac aagcttttgc 2373061 cgccgctcga agcgaggtga caggatatat caccatgtga aaccccatat cttcgaattc 2373121 atcggcacga taatatggcg ttttcccaaa ttcagtcata ttcgcaagga gcggaacggg 2373181 gatacgctca gcaaactggc ggaattcatt ctccgcctgt agcgcttccg ggaaaattgc 2373241 gtccgctccc gcctcaatgt aagcctctga acgttttatt gcggcatcaa gcccttcctg 2373301 cgccctggca tcagtacggg caacaacaat aagggagggt gccgcttgtt taatggcttt 2373361 tattttttgc gccatttcct ttatcggaac tagctgtttg ccatttaaat gtccgcattt 2373421 ttttgggagc tgctggtctt ccatttgaac ggctgctacc ctggcttcaa gcatctcccg 2373481 ggctgttcgg gcggcattta agacaccgcc aaatcccgta tcgatatcca caagcaaagg 2373541 cagatcagct gcacgcacaa gatctttggc ccgttcagct atctctgccg atgtgatgat 2373601 ccctaaatca ggcagccccc tgctggctgt ataggcagca ccggacaaat aaatagcaga 2373661 aaaaccggct tctttcgcaa gcaaagcggc catcccgtca tgggcgccgg gaatttgaag 2373721 aatgtccggt gctgacatca gcttgcggaa acgcccggca agctcctctt gtgacgattg 2373781 cttattgacg atccacgaca tgaaacaaaa tccccctttt acatgcagaa catgtctacg 2373841 aattcattta cgcgcatcgt ttgtaatgtc tcatagctgg tacagcgctc ataaatgtgt 2373901 ttgtgctgtt tatcaggaaa atgggttttg agattgtcag aaaacttttc cagcagtttc 2373961 ggcactgctt cctctcttcg aaaacgatgg ccgaggggaa actcacattc caccatttcc 2374021 gtgctcgttc catctttaaa atgaacctga acggcatttg agatggagcg tttatcaggc 2374081 ttcaaataat cctcggtata tgttttattt tcagtcactt ccattttatc acgaagttta 2374141 tctattctcg gatcattcgc tgtttcagct tcataatgct gtgcggtgat atcaccaaaa 2374201 agcaaaccga ttgctgtaat gtattggagg cagtgatcac ggtctgccgg attgtggagc 2374261 gggccttttt tatcaatgat tcggatagct gattcatgcg ttctgatgac aactcggtca 2374321 atctcgtcaa tccggttctt tacctgcggg tgaagaatga cggcggactc cgccgctgtc 2374381 tgggcgtgaa attccgcagg ataagacact ttaaataaca cattttccat gacataagcg 2374441 tcgagcggac gggcaagctt gatctctttc ttattgaata aaacgtcttg gaacccccaa 2374501 cccggtgcac tcaaggctgt cggataaccc atttcccctt ttaacgacat cagcgccaaa 2374561 tgaacacctc tgctcgttgc atctcctgcc gcccatgatt tacgcgagcc tgtattcggt 2374621 gaatggcggt atgtcctcaa tgctgcattg tcaatccatg cattcgaaag cgcatttttg 2374681 atttcttctc ttccgccgcc caaaagcttt gctgcaacag cagttgtcgc aactttgaca 2374741 aacagcacat ggtcaaggcc aactcgattt aagctgtttt ctaacgccag cacaccttgg 2374801 atctcgtgtg ctttgatcat catctcaagt acgtcgcgta ccgttaacgg ctcttttcct 2374861 tcagacagcc tcactcttga tacataatca gcagcggcaa ggattcctcc caagttatcg 2374921 gatggatgcc cccactccgc cgccagccac gtatcgttgt aatcgagcca gcgaatcatg 2374981 cagccaatat taaacgctgc cctcacagga tcgagaacat atgacgttcc cggcactttg 2375041 cttccattcg gcacagtcgt tcctggaaca atcgggccaa gcagctttgt gcattccgga 2375101 taccgtagcg ccaagattcc gcagcccagg gtatccagca atacatgccc cgctgttgta 2375161 tacgcttcgg cactagtaat ctctttctca agcacatagt ctgtgatttc ttcgataaca 2375221 cgatccgttt tcggcattct accagctcct ttcatgattt tgtttgatat cgcgggccca 2375281 tgtaactgac acggggacgg aagagccgat tattggcatg ctgttcgatc acatgggcgc 2375341 ataaaccgga cgttctcgcg ctgaaaaaga tcggcgtata taaaggaatc ggtatgccga 2375401 gcatccaata cactggggca gcatagtaat ccaaattcgg gtaaagccct ttttccttct 2375461 ccatcagccg ctcacccgct tcgcacatct catataaacg atggtcaccg gctttatcgc 2375521 ataattgctg cagcgcctct ttcatcatga gtgctctcgg gtccattttt ttcatataca 2375581 cccggtggcc gaagcccatg attttttctt ttcttttcag ttttgtttgc aaaagctgct 2375641 caaaatcaga tgtcgttttt gcctccaaaa gcaaatacat cacagcttcg tttgctcctc 2375701 cgtgaagatt ccctttcagg gaagcgacag ccccagtcaa agccccataa agatctgaat 2375761 gtgtagatgc aatgaccctg gccgcaaagg ttgaattcgg catctcatgc tcactgtaca 2375821 ggacgagcga ccggtcaaaa atctgttctt ccaatgaaga cggcaatttc cctgtcatca 2375881 tgtagagaaa attcgcactg taggataggg tttgaagcgg aagaatcggt tctttcttat 2375941 taatgatcct gtagctggca gcagtgaggg caggcatttt cccaagaagc tgataggcgc 2376001 gttctttgtt tgcggaagga gaccgatcat caatttgccg atcatagcca gcaagtgccg 2376061 acaggccggt acgcagacca tccattggat gagtgtcctc agggagcagc tcaagcagac 2376121 ggagatgatc agcaggcagg cttgaggcac tgtttatttt acgttccagc gtttccattt 2376181 cactttcttc tggcagcctg ccctccagca ataaatggac aagctccaga tagctttttg 2376241 tttcagaaag ttctattaaa tcatagcctc ttatcaaaat ctggctggac tgcgtgtcaa 2376301 gataagaaat atgagtttct gccgcaatca caccgtccaa ccctggagaa taatgctgtt 2376361 tctcctccat atcctcaacc tccgtttttg cgttttttgt ctatcaggtt ccgccaagca 2376421 aatacttgga aataatcagt ctttgaatct cgttcgtccc ttcataaatt tgcgtcacct 2376481 ttgcatcgcg aagcaggcgc tcaactggat aatccttcat atagccatat cccccataaa 2376541 tttgaacggc gtctaacgcc gcctttacgg ctgcatcgga agcaaattgt ttagccatag 2376601 acgcttcttt tccacagttt aggccgcggt tatgaaggtc tgcagcgtgg tagacaagat 2376661 gtcttgccgc ctcagctcta gtcgccatat cagccagctt aaatgatatg ccttgattgg 2376721 ctgcaatcgg ccttccaaat tgcactcgct gcttcgcata atcaacggca tgctcaagag 2376781 ccgcctctgc aattccgagg gcctgtgccg caatgccgat ccggccgaca tttaaattcg 2376841 ccatggcaat gtgaaagcca tccccctctt tgccaagcaa attggcttca ggcacttctg 2376901 cattatcaaa aatcagttcc gtagtattgg agccataaag ccccagcttt ctttcttttt 2376961 ttccaacggt aaaaccgggt gtgttttttt caacaataaa agccgaaatc ccgtgcctgc 2377021 cttgatctgg agctgttaaa gcaaatgtga tatagatatc agctgctccg ccattcgtta 2377081 tgaatatttt cgatccgttt aataggtatt tgccgttctt tttgattgct gttgtgcgga 2377141 ggctcccggc atccgacccc gagtgaggct ccgttagtgc aaatgcgccc aaatggtctc 2377201 ctgacgcgag atttggtata tatttcatct tctgttcttc gttgccgaaa tacagaatcg 2377261 gattcgtgcc gactgaggta tgaacggaga gaatcacgcc gacagccgcg ctgattctag 2377321 aaatctcatg aattgccaaa atataagaaa caacgtccgc tccagcaccg ccgtattgtt 2377381 ccggcaccgg tattcccatc agtccgtgtt tacccatttt tttgatcagc tgaaagggaa 2377441 attcgtccgt tttctccatg atttccgcag cgggagcaat ttcttttcgt gcaaaatcac 2377501 gcaccatttt tcgcatcatg acttgctctt gggttacatg caactcggcc acccccggat 2377561 ggaatagact tcaggaagtc ttctcctcat agtcataaaa accgcgtccg ctctttttgc 2377621 caagccagcc tgctttgaca tacttgcgga gcagcgggca aggacggtat ttggaatcgc 2377681 caaggcctga gtgaaggact tccataattg ataaacacgt atccagtccg ataaaatccg 2377741 ctaatgcaag cggacccatc ggatgattca tgcccagctt catcacttca tctattgcct 2377801 ccggcttcgc cactccctca tacacgcaat agatggcttc attaatcatt ggaagaagca 2377861 cacggttgga aacaaaccca ggaaaatcat tgacttctac cgctgttttc cccatctttt 2377921 ccgctaatgc cataacatct aaggccgttt cttctgatgt agccaagcct cgaatcactt 2377981 ctaccagctt cattacaggg acgggattca taaaatgcat gccaataacc cgttgaggcc 2378041 ggtttgttac agcagcgatt tctgtaatag gcaaggaaga tgtattgctg gccaaaatcg 2378101 tatgaggcgg gcaaatgcga tcaagtgttt taaacatctc agtttttgcc gccatgtttt 2378161 ctgcgatagc ctcaatcaca atgtccgcat gctctgcctc ctcaagtgtt tgagaaatcg 2378221 aaatgcggtt gattacgctc ttcacttccg tctcggtcct ttttcctttc tcagcatcac 2378281 gggccagctg tttcttcagc cgtttcaatc ctgcctccgc ggcctctgga ttcacatcat 2378341 acatccgcac ataaaagccc gcgtcggcgg ctgtttgagc aattccgctc cccatctgac 2378401 ctgcgccagc taccatgatt tgtttgattt ccattcaaat cccctttttc atcatgtttt 2378461 aatgaacctg cactaagacg gcgtctccct gtgctgcccc gctgcaaata gcggcaacgc 2378521 ccagaccccc tccccgtcgc tttaattcat aaacaagcgt catgagaatt ctcgcaccgc 2378581 tcgcgccgat cgggtggccg agcgcgatcg caccgccatt cacatttact ttttcaagat 2378641 cgaaacctac gattttttca catgtcaaaa caactgaagc aaaagcttca tttacttcaa 2378701 acaagtcaat atcttggaca gttaaaccat tctttttcag gagcttgtta atagcaaacc 2378761 ctggcgctgc cgccagctcg tgcgctggca ttcccgtagt tgaaaaacca agaattgtag 2378821 ccagaggccg tttgccaagc tcagcagctt tttcctcaga catcagcacg aacgcgccgg 2378881 ctccgtcatt gactccagga gcattgccgg ctgtgataga accgtcactt gcataaatcg 2378941 gagcaagttt tgcgagctga tccagacttg tgtcacggcg aatcgcttca tctttatcaa 2379001 caacgtttgg ttttcctttt cgaccgatcc agttgacggg aacaatttca tcctgaaact 2379061 tcccttcatc ggcggcctta gctgcccttg catgacttct caacgcccat tcgtcctgct 2379121 ctcttcgtga gattgcatat tccttggcag ctgtatttcc gtgaacagcc atgtgcacct 2379181 cgtcaaatgc gcacgttaat ccgtcataca ccattaagtc cctaagctcg ccgtccccca 2379241 tccgtgctcc ccagcgcccg gcgggaacgg catacggaat attgctcatg ctttccatcc 2379301 cccccgcaac aagtatgtcc gcatcctgcg cccgaatcat ttgatcacat aaagtgacag 2379361 cgcgaaggcc ggaagcacag actttattca gtgtttctga cggcacactc caaggcattc 2379421 ccgccagacg ggcagcttga cgggaaggta tctgccctga gccggcctgg acaaccatgc 2379481 ccatgacgtt tccttctaca tcatctccag agactccagc ctgttgcagc gcctccttca 2379541 tcacaatgcc cccaagctca gcagctttca cctctttcaa aactccgccg aatttgccaa 2379601 atggagttct tgcagcactt acaatgactg ttttcctcat ggtttcacct cattcagaag 2379661 atagacagcg cttacaattt ctagttgtct tctatgaatg tatgctttga aacgggcatg 2379721 aatgaatgaa aaaagaaggc tgcgtcaaac agcctccttc taacaactat tcatttttca 2379781 gcaatgccga agccttttct ggaaagtcgg taaacatgcc gtctgctccc gcttcaatga 2379841 gacgcttcat atcttccgga cgattgactg tatacggcct taccttaatc aaaccgttcc 2379901 tcattttctt cagtacttca tctgtgaccc ctgggctgtt tatcttcggg tgatagccgg 2379961 aagccggaat agacgcgata tatcgatctg cctgataaag cacatctgaa gttaatactg 2380021 cccgttcgat atgcggtgca agccgggcgc acagcgccaa gctgtcatga ttaaacgtgg 2380081 ataggatgac tctgtcctct acattaaatc gcttcactgc ctccagcact ttttcttcca 2380141 ttccctcata gcggatcacg ctgtttttta attcaatgtt gatgagaaaa tcctttttta 2380201 ccgcccacga gagcacatct tctagcagcg gcacttttat atcgctgtac gcttgatcgt 2380261 gaccagcggc cgcattcgca gtctttacct catcataggc tgtatccttc acgaatcctt 2380321 taagtgatgt cgtgcgatta agtctttcat catgaattac aacaatgcgt ccgtctttcg 2380381 tcagctgtac atcaagctct atcccatccg ctccggcttc aattcctttt tcaaatgcaa 2380441 gcattgtatt ttcgggaaat tgacctgatg ccccccggtg ggcaaaaatc tttgtcatcg 2380501 tttcacctca aaccctaaag ttttctccat tatacttatt ttgtcggctc cactctagga 2380561 ttaaggctgt atcaatctac tgatcataat aagaatcaat gccattgaca atcgcatctg 2380621 cggccttttg ctggtattct tcacttccca gcttgtccgc gtcagagctg ttcgtgataa 2380681 acccaagctc cgccaacaca cttggcattt gtgaatatgt aatgacgtaa aagtctgatt 2380741 ctttcacgcc cctgtctctc gtttgtaagg aagaaacgag ctgtgactga atatcggatg 2380801 ccagacgccg gctgttctcc ccttcataat cagattgaaa atacgtttct gttcctgaag 2380861 ctgaagcaac ccctgaattc acatgaatgc tgacaaaaag gtcagcctga ttggcacttg 2380921 ccttagccac tctttcctcc aaggtcagaa aatgatcgtc agaccgggat gcaacaggat 2380981 tggctccctc ctcttttagt ttgtctgtca catgctctga gacagccaaa ttaatatcct 2381041 tttcaaagag cccgtttccg accgctccac tgtcttcacc gccgtgtccg gcatcaatat 2381101 acactgtttt cccttctatc ggctctgctg cctgtgcaca aggcgcgagc gtcaaagcca 2381161 atccgcacag cgccaagctc ctccataaca ttctcaactt actccctccg gtcacgagtt 2381221 ctttcgcagc tgaatatctt ccagctgtaa agttccatta tccttctttg tatatttcac 2381281 caggacatgt gtctgatctg gcagtgattc acattcatca cgtttatcct tcggaacttg 2381341 tatcatggtt tcttctccat taagagaaac cgcaatcgta tgaggatcag ccgagccaat 2381401 gtattttccc tcttcggtaa acctcggcac tgagtcatcc gcacttgcaa cactgcaccc 2381461 cgaaagaaag agcgcagtaa acagcaaaag aaccgtttgt ttcacatgac cacctcttcc 2381521 tgatgtttgg cttttatctt tgaccagaat ggagaatttg taaagacaac gcgaatgcag 2381581 gcgagcaagt tccatgattt tcaaaagggc tatacgaccc gatcatttcc tgttgttaga 2381641 aagataacga gcagatttgt ctatgaggat ggctctaatt gaggcgccaa ttagaaaaaa 2381701 ttagcggaaa gaagcaactt tttattcatt ttaaaaaatt tgagaatagg gtgagcaaat 2381761 cgtttgacgg gtgggtcagc caagcgtaac cttttaaagg atatttactt tattgaaaga 2381821 agttaaagcc atgaaaaaat tcgttctgct gctggcggca gctgtcatca catgctccat 2381881 cggccaccaa atcagtggcg gctacaaagg ccccgaaaaa gagcggccaa aacatcactc 2381941 tgcactcaag atattcagtc ggtaaagcag atcaattgca ttaattttta catataggct 2382001 agaatatgtg cgaatccaaa cgaaagaaga tgatcaaatg aatcctaagt ataagccact 2382061 ttttgaacca tttacgttta aaagcggcgt tacaatcaac aaccggatcg cagtagcacc 2382121 gatgactcat tacgcttcta atgaagacgg tacaatatct gaagcggagc tcgactacat 2382181 catcccccgt tcaaaagaga tgggaatggt gattacagcc tgcgcaaatg ttacaccgga 2382241 cggaaaagca ttccccgggc agccggccat ccatgacgat tccaacattc caggtttaaa 2382301 aaagttagca caagccattc aggcacaagg cgctaaagct gttgtacaaa ttcatcacgg 2382361 cggtattgag tgcccgtctg agctcgttcc tcaacaggat gttgtggggc caagtgacgt 2382421 gtttgataac ggcaaacaaa ttgctcgcgc attaacagaa gaagaagtgg aaaacattgt 2382481 gaaggcgttt ggagaagcga caagacgcgc cattgaagcc ggctttgacg gtgtcgaaat 2382541 tcacggtgca aacggctact taattcagca gttttattct ccgaaaacca accagcgcac 2382601 ggatcgctgg ggaggaagcg atgaaaaacg attagccttc ccgctcgcta ttgtcgatga 2382661 agtgaaaaaa gccgcttcag aacatgcgaa gggtgcattc ttagtcggct accgcctgtc 2382721 tccggaagaa cctgagacac cgggattgac aatgactgaa acttatacgc ttgttgatgc 2382781 tttaggggat aaagaattgg attatcttca tatctcactg atggacgtga actcaaaagc 2382841 gcgccgcggt gcagatccga ctcgcacacg catggactta ttgaatgaac gtgtcggaaa 2382901 caaagtgccg ctgatcgccg tcggttccat ccattccgct gatgacgcgc ttgccgtcat 2382961 cgaaaacggt attccactgg tcgctatggg acgcgaaatt ctagttgacc ctaactggac 2383021 ggtaaaagta aaagaaggcc gtgaaaagca aatcgaaaca gtgatcaaag gcacagataa 2383081 agaaaaatat catttgcctg aaccgctatg gcaagcaatt gtgaacacac aaggctgggt 2383141 gccttataaa gattaatgtg caaagactgc cgaaacgatt cggcagtctt ttttcccttt 2383201 atataaatag tttgtgtaca catctaaaca gcaaaagaaa gagctcccca ccaacttcga 2383261 aaagaaaatc caggaaaaac ccctcacgct ttcttgcttt tttctttttc attcgtacgt 2383321 ctccttttta catgaatacg ccttacttac gattttgcag gagaaaggtt tcattttata 2383381 acggacacat ctagggtcga tcatgcttcg tgatcctata agatgtatga atggaccaag 2383441 agtgcaggta ataccgccat ttgctttcct tacttttcaa acctatcctt tactatatgc 2383501 ggatacttaa tattcttctc ccatactaca aatgtcccca aaacaaaacg cctcctattt 2383561 atcagcgcaa actaataaat aaaagacgtt tgatttaatg accacttaat aagctcatgt 2383621 ttaagaagcc ttatgctcta acctcagctt atccgcaacc attgcaatga attcactgtt 2383681 ggtaggttta gcttttgtca tgctgacagt ataaccaaac aacgaggaaa tggaatcaat 2383741 gtttcctctg ctccatgcca cttcaattgc atggcggatc gctctttcta cacggcttgc 2383801 ggttgtgtta aattttttgg cgatgtccgg atagaggact tttgtaatgc tgccgagcaa 2383861 ttcgatgtca ttgtatacca ttgagattgc ttcgcgcaga tagagatagc ctttaatatg 2383921 ggctgggacg ccgatttcat ggataatgct tgtgatgctc gcgtcgagat ttttcttctt 2383981 tggttcaggc tggctgctgc gtataatact gctttgcgat gatggcgcac gatgcgtcac 2384041 actgctggca tttccgctga cctggcggat atggccgaca aggttttcca tatcaaacgg 2384101 tttgagaata aagtaggacg cgcctaaatc gacggccttt ttcgtgacat cttcctgccc 2384161 aaaggctgtc agcataatga cattcggctg ttttttcaga tctgattccc tcagcctctc 2384221 taaaaccgca agtccgtcta gatgcggcat aataatatct aatacgagca catcgggatc 2384281 tttttcttta aacagcgaca ggcattcctg tccgttataa gcaacgccga tcacttccat 2384341 gtcttcctgt ccttctatat attcacttaa caggcttacc agctctcgat tatcatcagc 2384401 aacacaaact ttaattttct ccacgtttct tcctccccaa atgtagttaa caggattcac 2384461 ccttgctaca tgtttacatt cgacaaaacc gctatatacc ctctaaaaaa atcataatca 2384521 ccaatattag tggcatatct ttgttattct atgtttttct ctgtttttcg actaaaaatg 2384581 aaatttgaca aacaaggaaa cgtgaatttg tcgaaaaatc ttcttttgta tattttaccg 2384641 tatgtattct gagaagtgaa gagggatcaa aataaaaaaa ctgccggaaa ctccggcagt 2384701 cagcttgctt tttcttttcc ataaatatcg attcctgctt ctgacagcat ccattcaata 2384761 tgaacaccgt agccgcttgt cgggtcattt acaaatacat gggtgacagc accgatcact 2384821 tttccatttt gaatgatcgg gcttccgctc atcccctgta cgatgcctcc tgtttctttc 2384881 aacagtcttg gatcggtaat tttcaacacc attccttttg tcgcagggaa tttttgcggc 2384941 gttgtgctga cgatttcaat atcgaatttt tctactttgt catcatcaat aaccgttaaa 2385001 atttcagccg gccctttttt gacttcggta gaaaacgcaa ccggcaatgc ttgatctgat 2385061 atgttgtttt gaatcggctg atgcagtgtg ccgaaaatcc caaacgggct gtttctgtta 2385121 atatccccga tcgttttgcg ttctgaggaa aatcgcgcca gtttttctcc cggattaccg 2385181 cctgtccctt tttcaattga tgttacagtg gatttaacga tttctccatt ctccactaca 2385241 attggtttct ttgtgtccat atcggaaatc acgtggccaa gtgctccgta tttttttgtt 2385301 ttcggttcat aaaaggtcat agtgccgatg ccagcagcag aatctctgat atataacccg 2385361 attctgtatt tgccttctcc ttcatccttt tctgggatca gcttcgtttt gattttctgt 2385421 ttatcacgtt tgatcagtaa gtctaaagat tcaccagttt tcccagcctt ttgaataaat 2385481 ggggctacat cattcatttt ttcaattttc tgtccattca tctcaataat gatgtcgccc 2385541 gcttcaattc ctgccgtttc tcccggagat tttttgcctt cacttgtatt gatttgatga 2385601 aatccgacga caagaacacc gacggaatga agttttacac cgattgattg tccgccaggt 2385661 ataactttta aatcaggaag aacatgcact tttgtttttt taattggaaa tccggcaaga 2385721 tcatatacca attctgactc acctgatttt ttgcccgtca ccttgatttc atgcggatct 2385781 ttctttactg taaacgcttc tgaggattct gatgtctgag cgtttaccga taaactcgtt 2385841 tcaatcgctt gtgtttgggt ttcaaatact ctcatttgcg ttggaatcag taaatattct 2385901 tttagcggtt tgcataaacc tacacttaat aacgaaacaa ggagaattaa acctactgct 2385961 tttctgatgt tatcgggcat tcactacttc actctcctcg ctcctatccc acaccttctt 2386021 tatgacttgc tgctacatca tttaattttg ccttctgacg gcttatttat aactgtcata 2386081 tgaagaaaaa cattggatat actgatgaac gaatggatgt gcacgaaaaa aataagctgc 2386141 gcttctcgcg cagcttaccc agttgttttg acttgatccg cttgttttaa aagttctttc 2386201 gcatggcgtt tcgttaagtc ggttacttcg acacctgcaa tcatgcgccc gatttccgct 2386261 accttttcct gcttagagag cggcttgaca cgtgtcgtcg ttctgccgtc ttttaactcc 2386321 ttcgcaatat aaagatgcgt atcggccatg gcagccacct gaggcaggtg tgtaatgcac 2386381 agcacttgtg atcctattga caccttatgg atcttctcag caattgcctg tgcgaccctg 2386441 ccgcttacac cggtatcaac ctcgtcaaaa atgatcgatg tcacatcctg ttgtgaggaa 2386501 aaaatgcttt ttatggcaag catcacccgt gacagctctc cacctgaagc gactttcgaa 2386561 agggatttca gcggctcgcc tgtattggtt gaaattaaaa acttcaccag gtcaatccct 2386621 tgttcagtca gctgaacggg ctggccgttt acaagcggcg cctcttcatt gcgtgacgct 2386681 gttctgacct taaattccgt atcaaaagtt gatttttcca tgtacaggct ttttaattcc 2386741 cgatgaatct catcagccag ctttttcgcc catgtttttc ggatttgtga cacatttgcc 2386801 gcttccactg cgacatcttt gccgacggag tcaagctcct ttttcaagct ttgaaggtgg 2386861 ctgtccctgt tttcaatttg gtcaatctct tcttcaattt tagaagcata ttccaaaatg 2386921 tcttcaacag tggcaccgta ttttcgtttc agctgtttga tttcattaag tcgcgtctca 2386981 atatagttca ggcgttccgg atcaaattca agctcatcca gcatatttct catctgaaat 2387041 gtggcatcct caagcaaata gtaggagttc gaaacacttt cagacatttt tttcagcggt 2387101 tcgtttatat cagatatatc ttcaagctgc gctgatgcca ttccaaccca gtccaatccg 2387161 ccctgctcac tgcgaagcgc gttatatgca ttttgcagcg actcatatat cttctcaaag 2387221 tttgaaattt gctggcgctc ttcttggagc tgttcatctt cgttaagctc aagctttgcc 2387281 gattcgattt cttcgagctg aaattgaata agatcaagac gatgggccat ttcctgttcg 2387341 ctttcagaaa gctgcttaag ctttttgagc agcttcacat accgctggta cccttcctga 2387401 tacgttttga gcgcgctttc cacttcggcc ccggcaaact tgtccaaaag ctggagatga 2387461 ttttcgtctt ccattaacag ctggttatcg tgctgcccgt gaatatctaa taaaagcctg 2387521 ccgatctctc ttagtgaagc aatcgtgaca agcttgccat tgacacggca aacgcttttc 2387581 ccgctcgtgc tgatatccct tctcatgacg atcatttcgt ctgaaacgtc gattccctgc 2387641 tcagcgcata cgcctaaaac aggatggccg ctctccaaca gaaacagccc ttcaagttcg 2387701 gcttttgctt ccccatatct aacaaattca gatgatccgc ggcctccgac taaaagagaa 2387761 atggcatcta tgatgatgga tttgccggct ccggtttctc ctgttaaaac cgtaagcccg 2387821 cgttcaaaag aaaccgtcag ttcctcaata atggcaaagt ttttaatcga tagttcagct 2387881 aacaaacagc attacacctc ttatctttgt tagattttct gttacagcag ttcaaggagc 2387941 ctgtttttta cgccttctgt atcttcagga gtccggcaaa taattaaaat cgtatcatct 2388001 ccgcaaatgg tccccatcat ttcatcccag tccaaattgt ccatcagcgc cccgattgcc 2388061 tgggcattgc ccggcatcgt tttcagcaca atcatatggc ttgctgagtc tattttcaca 2388121 aatgcgtcca tcaatgcccg ctttagcttt gacagcggat tgaaacgctg gtccgccgga 2388181 agactgtatt tgtaagaacc attatttgta ggcactttta caaggtgaag ttctttaata 2388241 tcccgtgata ccgtggcctg cgttactttg tatccatcct gctttagcat gtcgaccaat 2388301 tcatcctgcg tttcgatttc attgcttgta atgatctctc tgattttaat atgcctctgg 2388361 cctttgttca tgtaagcacc tctatttcca agcttatctg ttcttttatg ttatatgatt 2388421 ctctgcacat tgtacatgaa tgcagaaaaa aggaataata gcgccctatt attccggtac 2388481 atctgctttt ttttctttta acgtcttatg tgcttcttct acaacgcgca tgatctcttc 2388541 ttccggcagt tcctggcctt cctgtccctc tcccggccaa tgcaaatgaa ggagaaactc 2388601 aatatttccg tctcctcccg tgattggaga aaatgacaag cctttacaga tatagccttc 2388661 agcggcagaa aaactgatca ttcgcttgag cacatcagca tgcactttag gatctctaac 2388721 aatccctttt ttgccgacgg attcccgtcc cgcttcaaac tgaggcttaa ctaaagccat 2388781 gcagtcgctg cccggtacga gcaaagtcct taggacaggc aggatgagcc gcagtgaaat 2388841 aaaggacaca tcaattgtgg caaactccgg catgcccttt gtaaagtctg ccggtgttgc 2388901 ataacgaaag ttcgtccgtt ccatcacgac gacccgttca tcctgtctaa gcttccatgc 2388961 aagctgatta tagcctacat ccacagcgta tgactgttta gctccatttt gcaaagcgca 2389021 gtccgtaaaa ccgccggtgg aggagccaat atcaatcata attttatctt tgacagagac 2389081 gggaaattcc ttcaacgctt tttcgagctt taagccgccc ctgctcacat acctcagcgg 2389141 gtttcctttg acagttaacg gaaggtcgcg gtcaattttt tctccaggct tgtccaagcg 2389201 gttttcgttt gaatagacga tccccgccat aatggctctt ttggcttttt cacgcgtttc 2389261 cgccagccct ctttccacta ataatacatc taatcgttct ttctttgacg tcatgatcca 2389321 attcctttgt gtgtctttgg tggcatcagt aatctaatac gatttgccac ctgctgtttt 2389381 gtcagtccaa tttcctcaag aagcgctgtt acacttccgt gttcaataaa ccgatcaggt 2389441 atacccattc tgtcaatcgg agtatgatat tcaccttgat catgagcgaa ttctaaaatc 2389501 gagcttccga aaccgccttc taagaccgct tcttcaattg ttaaaattgg caagccttct 2389561 tttaggatac tcttcatcat cttttcatca atcggcttaa taaaacgcgc attcacaacg 2389621 cgcacggaaa ggccttcttt ctgcagctct tcggctgctt caatcgccat ttcgattgtt 2389681 gtgccgaatg ttaagatgac agcatcgttc cctggacgca gcacctccca cgtaccgatc 2389741 ggaatcgttt tcaactgttc atccattttt acgccgagtc cgtttccgcg cggaaaacgc 2389801 attgctatcg ggccttcgtc atagctaagt gctgtatgaa ccatgtgctg gccttcattt 2389861 tcgtctttcg gcatcattaa gaccatgttt ggaatgtggc gcataaacgc aatatcaaac 2389921 acgccttgat gtgtctctcc atcagcgcca acgagtccag cacggtcaat tccaataaac 2389981 acattagcgt tttggcggca gatgtcatga acaacttggt catatgccct ttgcaggaag 2390041 gttgagtaaa tcgccaaaaa cggcttcata ccctgcattg ccatagctgc agccattgtt 2390101 gcggcatgct gttctgcgat tcctacgtcg aacatccggt cagggaattc ctttgcgaag 2390161 ccttcaagct ttgaaccgac aggcatagcc ggcgtaatgg ctacaatgcg tccgtcctcg 2390221 cgcgccattc gctgcacagt tccgctgaca agaccgctcc acgaaggagc tgcggctttc 2390281 ggctttacaa agtcaccggt attaatttta tatggtccgg taccatgcca tgtcccaatc 2390341 gtatcggtct cagccggttt gtaccccttc ccttttttcg taatgacgtg cagaagaaca 2390401 gggcctttcg tttttttggc gtattgaaga ttctcaatca gctcatgata agaatgtccg 2390461 tccactgggc ccaaatacgt aaaaccgagc tcctcgaaaa acattccgga gacgagcatg 2390521 tatttcaggc tgtctttgac ccgttccgcc gtggcggcaa gcttgccccc aactgccgga 2390581 atctttttaa ataagtattc aagctcatct ttgacccact ggtatttccc cgcagtgcgg 2390641 agccgtccga gcatagagtg aatggcaccg acgtttggcg caatactcat ttcattatca 2390701 ttaaggatga caatcatgtc ttttttctcg tcgccgatgt ggttaagggc ttcgagcgcc 2390761 ataccgccgg tcagcgcgcc gtcaccaatg atcggaataa tatattcatc cgttccttta 2390821 atatcacggg cagctgccat tcccatcgcg cctgacagag aagtcgagct gtgcccggtt 2390881 tcccaaacat cgtgctcgct ttcactccgc tttggaaatc cgcaaagccc tttgtactgg 2390941 cgaagcgtcg caaattcttt tccgcgtcct gtcagcagct tatggacata cgactgatgg 2391001 cctacatccc ataaaaattt gtctttcggg ctgttaaatt ccttatgcag ggcaacagta 2391061 agctctacga cacctaagtt tgggccgatg tggccgccgg aagcggataa acttgtaatt 2391121 aaaaactgac ggatttcatc acttaatttc tctaattcat caatggacat gttttttaaa 2391181 aacgacgggt cctgtattga taaaagatcc aaagcggatc aactcacttt cagcatgaat 2391241 ttctgcaatg atacatgtct tttgcatgcc gagctgacaa taatctcaga cataaaaaaa 2391301 gacaaacgcg cttttccttt tcatttttca tataaactgc ttacatttta ccatacctcg 2391361 tgcagccgct tcaaattagg atcgttttag tgatctcttg ccgcaattaa atcacaaagc 2391421 tcatataaaa ggtctttttg aagagagagt ccgccgatca atcgcttcgc ctcttttata 2391481 tgaacatcca atttatgttt ggccccttcc aatgaaagaa gcgacgggta tgtcgatttg 2391541 tcatttgtgg tatccgagcc gacacgtttg ccgattttct cttcactgcc ttctaaatct 2391601 aaaatatcgt ctctgatttg aaatccgatt ccaatgtggc tgctgaaggt acgcagtgtt 2391661 tcaatgtctt cctcaggcgc atcagccaaa atagcaccgg cgattacaca aaagccaagg 2391721 agcttggcag ttttccgttc atgaatggat tcgagctctt caagcgtgac ttgtcggttt 2391781 tccgcttcca tatcagctac ttgcccaccg accatgcctt cggtgcctgc cgctgaaatc 2391841 agttcattca caagccgcag gcgcttttct gctgacacct cgtctgacac gtgggaggta 2391901 atcagcttaa agctttctgt gagcagcccg tcacccgcta atactgccgt cgcttcacca 2391961 aacactttat ggtttgtcgg cttcccgcgg cgcaaatcgt catcatccat gcatggaaga 2392021 tcatcatgaa ttaacgaata cgtgtgaatc atttcgacag cacagcccac cggaatgccg 2392081 tctttttcgc tttttccata tgcatttaaa acagccagta caatcagagg ccgcaaccgc 2392141 tttccgccgg cctgtagaga atatagcata gatttcttta atgagtccgg catatcaagc 2392201 ttttctgtat agacagaaag ctgattttca attgtttttt tccggtccgc cagaaagctc 2392261 gttaatttat ttgtcacctt cgtcttcctc ctgaacactg aaaggtgcca gttcgccgtc 2392321 ttcttttaaa atgaagtcca tttgcttttc gactttttgc agcttttcat ggcacatttt 2392381 tgacagagcc atgccttctt ggaaatagtt aatggcttgc tctagaggca catctccctc 2392441 ttcaagcttt gatacaatgc tctcaagccc tttcatcgct tcttcaaatg tcatgttttc 2392501 attttttttc acgtctgtca tttttcttcc cctctctttt ctaatacttc acaggtcagc 2392561 acgccatcct tcagcttgat ttcaagccgg tcctgctctt ctatttgact gacactttta 2392621 atgagtttat cttctttata agccaagctg tatcctcttt ccatcacttg aagaggactt 2392681 agtgcattca gcttgccaag aacggtttga aattgggaat gcagctgctt catttggata 2392741 ttcatatttt ttctcagctg atttgtttgt tcctggtatc gtgttctcgc ttgtttcagc 2392801 tgttcatgag gatgcaatgc ctctaatctg tacgtttcac gctccagctg tctgcttttc 2392861 cgatctaaaa gagcggtcag ctgtgcttga aactgctggt acgcgaggtc aaactgctgc 2392921 tctttttgcg catacaaacg ctttggaaaa cgaaaggcat aggacgattg cagcgtttgt 2392981 atccgttctt ttttctggcc gagatgctgc tgcattgctc ttgtcattct gacttccgct 2393041 gtttttgtcc gttcgattaa atcagtggta tgaggcacag caatctcagc tgctcctgtc 2393101 ggcgtcgcag ctctgatatc ggcgacaaaa tcactaatcg taaaatccgt ctcatgtccg 2393161 actgccgata taatcggaat attggaagca aagatggcgc gtgctacaat ttcttcattg 2393221 aatgcccaca gttcttctat cgaaccgccg cctctcccga caattaatac gtcgcaaatc 2393281 tctttttcat ttgcctcttc aatgcgcgta acgatggatc tgctcgcatt ttcaccttgt 2393341 acgagcgctg gaagaacaat gacttttaca aggggatatc ttctttttag agttgtaata 2393401 acgtctctga cagcggcacc cgttggagat gtcacaaccc cgattgtggc tggaaatgcg 2393461 gggatttgtt ttttgtagcg gtcgtcaaat aaaccttctc cggcaagctt cttttttaat 2393521 tcttcgtacg ctaaataaag cgctccaacc ccgtcaggct gcatttcttt ggcatataat 2393581 tgatagtttc cgctcggttc atatacggaa attccgcctc tgaccagcac tttcattccg 2393641 ttttcaggtt taaaaggcag acgctcgctt tgtctcgcga acatcaccga ctgcattctt 2393701 gcgttttcgt cttttaaagt gaaataaata tgccctcgtg tgtgtatctt tacattcgac 2393761 aattcgcctt taatccaaat attttcaagg tgaggatcta catcgaattt tcgttttata 2393821 tactttgtca gcgctgagac ggtcacatac gctgcttcac ccatgtctaa aaactcctct 2393881 cctaagcatt cctgcaccat aactaaagaa aacccgccct ggctttagga gcctgaagaa 2393941 gcgggtatcg tgctcatatt caaggcgggt aaacatttcg cctgtgaata tctccaatta 2394001 tctatgataa cgtacgtttc gcagatttaa cagtattatg cgcaagcatc gtgatggtca 2394061 tcggacctac tccgcccgga accggcgtta tgaaggacgc tttttccttt gccccttcaa 2394121 attcaacgtc tccgcaaagc tttccgtttt ccagacggtt aacgccgacg tcaatgacaa 2394181 cagcgccctc tttgatctgg tctgcactga tgaagttggc tctgccgact gccaccacca 2394241 ggatgtccgc ttttttcgta tgttcagtaa tattttctgt tcttgaatga cagtaagtaa 2394301 ccgtcgcgtt ttcatttaat aaaagctggc cgacaggttt gccgacaatg ttgcttcggc 2394361 cgactacaac aacctcttta ccggaaaggt caatattggt tttcttcaaa agctcaacaa 2394421 ttccatgagg cgtgcaagga agaaacgtat cttcgccaag cagcattttc cctacgttta 2394481 acggatgaaa accgtctaca tctttatcag gggagatacg ttcgatcacc gctttttcag 2394541 aaatatggtc tgggagcgga agctgaacga gaatgccatg aaactcaggg tcttggttat 2394601 attgatcaat aatggaaagc agttcagctt ctgtgaggct gctgtcaaat tgatcgagct 2394661 tgaaattcat tcccattgtt tctgccgctt ttttctttcc tcgcacgtaa gagtgagaag 2394721 caggatcatc tccaatcaaa ataaccgcca gtccgggagt gacgccttgc tttttaagct 2394781 cttctacctc ttttgccaat tgttcgcgtt tttctctagc cgtttctttt ccgtcgatga 2394841 ttgttgcagt cattttcttt cctcctatga ttgttcaata tcagatttaa tgttagaaag 2394901 aaccccgttt acaaactttg tcgctttgtc atcaccaaac cgttttgcca gctcaatcgc 2394961 ttcgttcatg gagacattca ccggaatgtc ttcggcatat gccatttcat atgctgccag 2395021 gcgcaaaatc gcacggtcaa cattggcaat ccgatcgagc ttccaattca ccagatgctt 2395081 ggagatcatt tcatccagct ggtcttggtg ttccaatacc ccgtgtacaa gctgttcaaa 2395141 gaaaggatct gttttttctt catccagtgc gtgttctatg gcttcattca ctgcaatatc 2395201 gctgacatca atttgaaata gtgcctgcaa agctttttct cttgctgttc ttcttttcat 2395261 tttctttctc ctttgatcct ctttatccgc ttgtcgttaa gccacaaaga gatcataaca 2395321 tatttttttc gtatccgcat attgaaatca aggttttttt accctattac cgaatatttt 2395381 cacacacctt aatatgatta ttcggatttc acgttcatga agaaactcgg ctatgtaagc 2395441 cggctttctt catgctttga aataaagggt aacgtgtaaa aaaaccaaag ggccgccctc 2395501 cccttggttt cgtgttaagc catttacatt tcttcgtcga tttggacttc ttgggctttt 2395561 gtgtcaaatt gaatgccgac gatgtgaata ttgatctcgt taatcgaaag agacgtcata 2395621 tttaataagg tttgacgaat gttttcctga acggatgctg caactttcgg aatcgaaacg 2395681 ccaaatgtaa cgacacagta tacatcgatc gtaattccgt catccgccag gtcgactttg 2395741 acacctttgc catgattcac tttgccaaag cgctcaacga cgcctgtcgc aaagtttccg 2395801 cgcatttcgg caactccatc aacttctgat gctgcaatgc cggcaatgac ctcaatgacc 2395861 tccggtgcaa tctcaacctt acccaaatgc gtatcttcgt gatccatttt aagcaagctg 2395921 ttgtctttca ttcaattcac ctccgtaaaa attatgagcc cattacatca tatgtttcta 2395981 aaaatttcgt attaaactct ccgctcacaa atgtttcgtg ttcaagcagt tttaaatgga 2396041 aagggattgt tgtctcaatg ccttcgatga cgaattcgct caatgcgcgc ttcatgcggg 2396101 caatcgcttc atctctcgtt tttccgtatg tgattacctt tgcaatcatg ctgtcatagt 2396161 acggtgggat ggaatagcca gggtacgcag ctgaatcgac acggacacca agaccgccag 2396221 gaggcaggta cattttaatt tcaccaggtg acggcatgaa atttttgctt gggttttctg 2396281 cgttgattcg gcattcgatg gcccagcctt caaattcaac atcttcttgc ttgaggctca 2396341 gttccattcc tgaagccact ttgatttgtt ccttgatcag gtcagttccc gtcaccattt 2396401 ctgtgactgg gtgctccacc tggattctcg tgttcatttc catgaagtaa tagcgctgtt 2396461 cattgtagtc atagataaat tcaactgttc cagcacctgt atagccaacc gctttggcag 2396521 cctttaccgc tgcatctccc atttgctccc tgatttctga atcaagggca ggagatggtg 2396581 attcttccaa aagcttttgc aggcgtcttt ggatcgagca gtcgcgttcg cccaaatgga 2396641 tcgtatttcc gtagttatca gcaagcactt ggatctcaac gtggcgaaaa tcttctatgt 2396701 atttttcgat gtatacacct ggattcccaa atgcagttgc cgcttcctgc tgtgtaatct 2396761 taatgccatt aatcagttcc tcttcagtgc gggcaaccct aattcctttt ccgcctccgc 2396821 ctgcggtggc ttttataatt acaggatacc caatttcatt agcaagcgaa accgcttctt 2396881 ccacattttc tataattccc tgtgaacccg gtacgattgg cacgccggcc tgtttcatcg 2396941 tttcccgcgc aacgtctttt gttcccattt ttgaaatggc gtcagcgctc gggccgacaa 2397001 acgtgacatt cacttcttca cataattcag cgaaatcagc attttcagct aaaaatccgt 2397061 atcccggatg aatggcgtcc gtgccagtca gctttgcaac actcacaata tttgtaacgt 2397121 ttaaatagct gtcttttgat gctttcggtc cgatacaaaa agcttcatcg gccatttgaa 2397181 catgaagggc atctttatca gcttctgaat aaacagcgac agtctcaatt ccgagctctc 2397241 tgcaggctct gatgattctg acagcaattt ctcctctgtt ggcgatcaat agctttttaa 2397301 tcatgttcag tctccttact ccgcttttac aagaaataga ggttgtccgt attcgaccag 2397361 ctggccgttt tctactaata cttcaacgat ttcgcctttc acttctgctt cgatttcgtt 2397421 gaaaagcttc atcgcttcta caatgcagac aactgtgttt tcatttactt ttgaaccggc 2397481 tgttacatac gggccagctt ccggtgatga agaagcataa aatgttccta ccattggtga 2397541 agtgatttta tgcagattct catcttgctt tggtgcttct tgggcaggtg ccgctgcttg 2397601 ctgcgcttgc ggctgaactg cctgcggagc ctgtgcttgt acaggtgctg ccggtgcctg 2397661 ctgcatgact tgaaccgtgc ctgcttcgtg ttttttcagt tttaaggata caccttcatt 2397721 ttcatatacg aattcgtcaa ttgtagactc gtcaattgct ttaatcagct cgtggatttc 2397781 tttgatattt aacattcaat cgcactccta tgtatgaaat ttcttttttt ataggttact 2397841 actaaaagta catactatgt tcatcttaca ggagcggact tttgaattca actctaatat 2397901 gacagcaacg caaaaagccc gcttgtttag cgggcttttt tccctcattc ttatttagag 2397961 ggttcaaatg tgacagcgac atctttcatt gttttgattt cttttgccac aaggtctata 2398021 atggctgtcg ccttcgattt agagtgtttg tctgatttga ctgtaatatt gattttatct 2398081 ccttcagcat taacaagcgc atcctcgtaa ccttgtgttt taatcagcgt ttccagctgt 2398141 ttttctgttc cttccacttc actgagagcc gtcattttat cgtatgcttc gcttttctcc 2398201 ttggctgttg catcatcgct tgacacaatg gcattcagct cttctctttc tttgcttctg 2398261 gcatcttcta aatcaagacg gtacgttgta aacaaatcat catcggctgt ttccgtaaca 2398321 acagttcctt tttcactggc ttcagcggat gtttccttgt ctgctgatga atctttcgtt 2398381 ccctttgttc catcttcttt tcctttttca gtttctgtac cgcttttttc cttcgtgtct 2398441 tgcttggcag gcgctttttc agttgcgacc tctccgctgt cagacgcgct tttttcactt 2398501 tgcatctgca cggcgttttt gctttccggc gacatgatat agtagacgct taacaccacg 2398561 acaagactga gcattgttaa tagccaaacg gtttgttttt taagcattta tgaatcctcc 2398621 tttatttttt taggggcaac cgcaacccgg tggcttggaa catccaggac ccgtgtcacc 2398681 gcttcgataa tggtttgttt tatttgaacg ttgtccactc cttgagcaac aacgagtaca 2398741 ccgcgtatat caggtttttt cgtttggacg acgacaggtg tttctttatc gccgtttttg 2398801 atcatgacga tttcttcctc cgatgattgg tctgtaacgc ttctttttcc gccttctttg 2398861 tcagtttctt cagtggttgt atttttgttt gatttgtttt tttcgtatac tttcagcgac 2398921 gttgcatcta cattcacgac aaccgagaca tcgtccacac caatgattgt ttcaagaatt 2398981 tctttcagtt gattttcgta ttctttttca tagtcatcga tcgagtcttt aggtttatca 2399041 gattttgagg ctttaaacac ttcggctgtt ttctctttgc tgtctgcgga atgttgtgat 2399101 gatacggccg ttatcgtttt ggcgttttca gttttctcag gtgaagaaaa cagctggctg 2399161 acaagcataa aggaaactcc gagaacaaaa acgaatagaa agtaatgata tttggtcagc 2399221 ttcggctttt cgccgtcctt cgtttgtccc ggaagaaact gctttttcaa tacattccat 2399281 aatccgtttt tattcattgc cgacactctc cccgccttcc atatgaaccg taattttctc 2399341 acttccgatt tcccaaatgt ccgcgagctg cgtttgtatc tgtttggctt ctttttgttc 2399401 ggctgcttct tttgttacgt atgcatgatc tgtatcaatg tggaccggcg cgaccgtttg 2399461 gaccgttttt tcagaagacg gggccatata cacgctgatt gttttaatat cctcttctga 2399521 atctaccttt tctcctgccg tgagtttgat gcggcctact ttatattcat catgactgaa 2399581 tctctcctcc gctttctttt ttagttggac agccatttct tctagaatat atgcgcgctg 2399641 ggaagcttgt atttctattt tttttgaatt gatttgattt tttatgtcgg cagactctga 2399701 ctgcccgttt tttgtgaggt attcaaagat gacttcgggg tctgtcttga aaagtttaaa 2399761 aatcggcgta agcatgacga caatcaagag caggctgact accatttttg cgtacttttg 2399821 catgctggag ctcggcagca gcatatcaat cacaattgca aataggataa acaacacgat 2399881 ggtggtaagc cattccgtta aaaaactcat ttgcctgcct ccttcatttc atcatcatcg 2399941 tgaggtttcc ggctgtgatt atgacagtaa ggcttaaaaa aaacatgaga gacacaatgg 2400001 cgagagctgc aaaaatataa atgacgcttt tgctgatgac gtcgaggcag gtgatgacgg 2400061 gcccgcctcc tagcggctga agaatcgcgg ctgccagctt ataaataaaa gcgagggaaa 2400121 gcactttgat tgccggaaat gccgcaatac agatcaaaat agcgacaccg agaatcccta 2400181 ccgtattttt cagcagtaaa gaggcgctga ttactgtatc tgttgcgtct gtaaacattc 2400241 ggccaagcac aggaataaaa tttccggtta taaatttagc cgtcctgagc gtaatgccgt 2400301 ctgtcactgc agctgacgct ccctgaacag agatgacgcc gagaaagatg gtaagaaaaa 2400361 cagccagtgc tccgatggcg atatttctga gcaggttagc cagctgcgtt actttgtatt 2400421 gttcagtcat cgtgctgaca atgctcagaa tcgctgataa aaaaatcagc ggcatgacga 2400481 tattctgaat caagagaccg ctcgtgttca tcaggaagag gataacagga tgaaagaagg 2400541 cagcagatac agctccgcct gaggaagcca aaagcgccaa gaggagcgga atgagcgcca 2400601 ggataaagct ggtcatcgtc tgaatcgcct cagttgcata gttaattgcc acatgaaagc 2400661 tattaagcgc aaggataatc agcaccatgt acacaattga gtaagcgacc ttactgacgg 2400721 tgctttgctg aaaagcattt tgcaaaagct gcagaatgac gcaaaaaatc gtgagcaaaa 2400781 tcaatgtgcc cagcagcttt ccgttggcaa gcacttcatg aaacaaataa gaaaagagag 2400841 ctttcagcca ttcttgcggt gagaatgatt tatcgccatt gataaactcc attaagctgc 2400901 ctttttggct ttccggcagc agtccgccgt attctgtcat aatgtcattc caaaattccc 2400961 cgatcttatc tgtttcaagc gaggctgctg tcctttccgc taattgctcg gctgtttcag 2401021 catggtcttc cgtttgttct gcattaccag ctgcttgtac aatttctgca cggcctgcta 2401081 tgatcagcac ggccaaaagc aaaacccatt gaaagcgctt caatctaccg cctcctttcg 2401141 gttatgacat agaaggtata agtccgagaa tcgtttcgat aatgacggtt aaaataggca 2401201 cagccattac gagtattaaa attttccccg ccaattctat tttcgaggcg atggctcctt 2401261 gaccggcatc ttttgtgagc tgtgccccga attcagcaat ataggcgatt ccgataatct 2401321 ttaaaatggt ttcaacatag accatgttga catttgcatt aatcgcaatt ttttctatca 2401381 ttcgaataat gtcgtagatt tggtctacca aataaagaaa aatggcacat ccggcaaaaa 2401441 cgacgattaa aaacgcaaaa gtcggctttt gttcttttac aattaaagaa aggaaggtgg 2401501 cgatcagccc taaacctaca atttgaacaa tgtcaatctg caagcccccc tatccttgga 2401561 ataaaaacac agcttttatc tttttaaata ggtcatctac aatcgtggcg accataaata 2401621 aaatatagat aaaacctaac agcgtcaccc actgagcata ttctttcttg cccatctgat 2401681 ccaatatcgt gtgtaaaaaa gcgaccacga ttcccactcc ggcgatttga aatatgacat 2401741 tcacgtctac tcccatttta tttttgctcc cctcacgttt acatcaatag aagaatgagt 2401801 aacaagcccg ctaaaaagcc caaacttttt atcatctttt cgtttttcgc ttgcgcctgc 2401861 tcagcatccg cttctgaggc ttccaaatgt gtcagcgcca gcttgatgtg cttttgctga 2401921 gagattcgat catgaatccc aagcgtctcg ccaaactgct tcagcacttc gtattcgctt 2401981 tttttcaaag acagggtgtc ccataccttc tttaagcttt gctcccacgc cgttttcgcg 2402041 gaatcacttc ccttgtccag ctgatcactg aatgcggaaa aaagagttga aacaggctgt 2402101 gcgagctgtt tggcaatctg ctgtgaagca gtatgaagcg gtgtatggcc gtacatgatt 2402161 tcagcctcga gggattgaag cgccgcacgc agctggcgga tttgccgcgg ccgttctgta 2402221 taaatcttcg ccatctcaaa acctgtccat gttgtcgcta ccacaatgaa tacagcgccc 2402281 agcagcttca gcatgttttc acgcccgtcg tcctagacag cacatttccg tctttgtcat 2402341 aaatttggct cactgtgccc ggcccttttg ctcttgataa ttccaaatag cggtcaaagg 2402401 ctctttcttc ccacaaacgc ttcaatgaag gccgcttcat caggtcggat atactccagc 2402461 catgcgccga tacgattact gaaacaccgg catgcagcgc ctccagaagt gcatctgtat 2402521 cttccatacg cccgatttca tcgacaatca tcacctcagg gctcatggat cgaatcatca 2402581 tcatcagccc ttcagctttt ggacaggcgt ctaacacgtc aattctctga ccaaattgat 2402641 gctgcggaat accgcgaaga catccggcaa tctctgaccg ttcatcgacg atccctgtct 2402701 ttacgggcag catgtttttt ttgccggtgc ttgagagcct cgcaaggtcc cggagaagtg 2402761 ttgttttgcc ggtttggggc ggtccgataa tcagcgtatt cagccagctg ttttgatata 2402821 agtatggaag cagcggctcc gcaatcccca gcttttgccg ggcaattcgt atattaaaag 2402881 atgcgatgtc acggaggcct ttcacacctc cgttttccgt aatgactctg cccgccagtc 2402941 cgactctgtg gccgcctctg atcgtgacat accctttctt cagctcttct tcaagtgtat 2403001 acatactata gttgctgagc cggctcagga tcagatgggc atcctcggcc gtgcccgcat 2403061 aggacaaata aacaggttgt cctcttcgaa tcaattcaac agggcggttg atccgaattc 2403121 tgacttcttc gatttccagc cattgttgtt ccggtatttc agaaagggcg tttttcatgg 2403181 attcagggag aacctcagcg atttcattca acagagcctc ctcctttcta ccgattggct 2403241 tctttaaaat gtatgatgtg aggcagactt tatgacaagc ctctctttat ttatgaacac 2403301 ccgccaaaat caagacaaca cccgtaaaaa tcagaatcag ctttgcatac gaaagctgcc 2403361 cggcaatttg gtagattccg acagtcattg taatgataaa aatcaacgga ccgacaatag 2403421 cgagaatgct gttaaccaca accgccttcc ggacatcgtt ggtcacaagc atgacaattg 2403481 ctgccgtcag ctcaatcata gaggataaaa ctcgtaatcc cgccattgtt aaaacagtag 2403541 aattgatatt tccaagtaaa aatttcatag cactctccca acctcccatt tttttatatg 2403601 atatgctcta gcttgctgaa gtagtcttgt cattttcgta taaaagaaag attctgtttt 2403661 tgggcacaaa aaaagcctgc tcccatttgg gaacagactt ctttttttct ttctatgctc 2403721 ttgaaacgta agaaccgtct gatgtattga caacaagtgt gtcgccttca ttcacaaaga 2403781 acggcacgtt tacaacaagc ccggtttcag ttttcgcagg ttttgtaccg cctgacgctg 2403841 tatcaccttt aataccaggt tcagtttcaa caactttcag ctcaactgtg tttggaagtt 2403901 cgataccaag tgtttcatcc tggtacatca tgatatgcac agacatgttt tctagcaggt 2403961 attttaattc ttcttcgatt tgagttgcgc tcagttcaag ctgctcataa gaagaagtat 2404021 ccataaatac gtgctgatct ccgtttgcat atagatattg cattgttttg gtttcgattt 2404081 gcgctttcgc tactttttca ccagcgcgga atgttttttc ctgaatcgcg ccagtgcgaa 2404141 ggttgcggag tttagagcgg acaaatgccg caccttttcc aggttttacg tgctggaagt 2404201 caacgacgcg ccaaatgccg ccatctactt caattgttaa tcctgtacgg aaatcgttaa 2404261 ctgaaatcat gtttaatgtc ctcctatatt ccaatcacaa aataataagt tcttttgggg 2404321 aatgggtgat tgtccggttg ccgttttctg taatcacgat gtcatcttca atgcggacac 2404381 cgcctgtttc tggtatgtaa atgcccggct ccactgtgac caccataccc ggttcaagga 2404441 tagctgaaga tctgacggat aatcccggcg attcatgaac ttccatgccg agcccgtgcc 2404501 cggttgaatg gccgaaatag tcaccgtagc cttttgcagc aatatgatcc cttgtgaggg 2404561 cgtcagcctc ttttcctgtc attcccggct taatatgtgc gacgccaagc gcctgagcat 2404621 caaatacaac ctgatagatc tccttcaatt gatcactggg ctgacctaca gcgaccgtcc 2404681 gggtaatatc agaacaatat cctttataat aagcgccaaa atcaagcgta acaaggtctc 2404741 cgctttcaat cagtttgtca ctggccacac cgtgcggaag gcttgaacga aggcctgagg 2404801 cgacaatcat atcaaaagaa gagctgtctg ctccctggct tctcatataa aactccagct 2404861 cattggcaac agcgatttca gaaatgccgg gtttcataaa cgtcaagata tgtctgaagg 2404921 catcatctgc aatcttcgca gcttcctcta atatcttaat ctcttcacta gacttaatca 2404981 agcgcaactt ttccacggat tcagccacag gcactaattc ggcatcactg ataacggcgc 2405041 tgtatgaagc gtaagtgcca tatgtcatgc tgttctgttc aaagccgaga cgcttgatgc 2405101 caaacgattc aacagtgtcg gcagtggtct gaatcaagct gccgccatgt tcaatgatct 2405161 caaaaccctt tacctgaacc ttcgcctgct cagtataacg aaaatccgta ataaacgctg 2405221 ctttgtcacc cgatataaca gccaaacccg ccgaacctgt aaaccctgtc atatagcgta 2405281 cattagtgtt gcttgtaatc agcatgccgt caattcccag ctgtccaaac aggtttctta 2405341 atttctctag cttcatcttg attctccccc ttgctggctt aataagtagc gaacagcaag 2405401 cttgtagcct tcagctccaa gaccgacaat ctgccctttc gcaacaggag cgataaccga 2405461 ctgatgcctg aattcttccc tggcgtataa gtttgataaa tgcacctcta ccacaggaag 2405521 actgatgctt gaaacagcat ccctgatcgc atagctgtaa tgactcaggg cgccggggtt 2405581 cagaacaatc ccgctgtatt gctcctcagc ctcatgtatc gcatctatca aatcaccttc 2405641 gtgattagac tggaagaaag tgagctggat atgtaaggct tcagcaaact gaaaaagatc 2405701 tgtttcaata tcggtcagtg tctggcggcc gaatacttca ggctcacgac tcccaagccg 2405761 gttaacattc ggtccgttca aaatcaaaaa atgaggcaca caatctctcc ttttcgcgag 2405821 ggtttctcat gtaaaaaatg ttcacttctc gtgaacattt tatcatactg gaaaaggatt 2405881 atacactatt ctctatgcat tcccagcgca cgtgcaagct tttccgaatt cagctcattg 2405941 tattcaaatg aaatagaata cccgacaaac agcccgtaaa gcaaataaat gcaaatggtc 2406001 gtaataattg tatctgatgt cagttcggtc accgtgcgca catctggaaa aatcggatta 2406061 aaaacaaaaa acacgagcag ccaaagcacc aagccgtata aaatacccgg ccacattgtt 2406121 tttaaacgtt tcaatagaag aaaataaaga aatgctgcgc caattgaaat tactccaatc 2406181 aaaatgatgc tgattaccgt tcccagccca tgttttttcc actctccgag tacaaacggc 2406241 tgcaatatca tattcgggct gatttcggaa aaatgaaaca aatatgcgat ataagcaacg 2406301 aaactccaaa gtacgcctcc gcaaaaacct gttgccgcca ccctgccggc cattgaaaca 2406361 ggcggctttt gcttctcatt caattcttca ttttgttctg tatctttttc gcttgtcatc 2406421 atggcacctc cagttaaagt gtgcccaaaa aatgaaatgt caataaaaaa gctcacactt 2406481 tttggcagct gcgagtaaaa tttgaaaata acgggtataa tgcatgtaga aaaagcaagg 2406541 ctatggcaat tttttcagcc tgtcaatcta gaggtttagc gctgtttcct gtacaataga 2406601 gtgaaaggaa atggttagca atcctaaaga aataggcagg ttgataatat gtcaaaacat 2406661 aaagttccgc ccgcttacgg cgggcaggct gttgtggaag gcgttatgtt tggcggaaag 2406721 catcattacg ttacagccat cagaagaacg gatggaagca ttgacttttt taagcttcca 2406781 cgcaaacaca acccgaaact gaacatcgtg aaaaagatac cgtttttacg ggggatcgcg 2406841 gccattatcg aagcgagtgc aaacggcaca aagcatttga atttttcaag cgaacgttac 2406901 gggctcgatc catctgaaga cgagacactt gagcaggaag aaaaaaaatc ctctgggctg 2406961 tctatgtatc tcagcctcgc agttataggc gtcctatcat ttttgttcag taaattcgta 2407021 tttacattgg ttccagtttt cttagcggaa ctgacaaggc cgattttttc cttgaacaca 2407081 gcgcaaatcg cgattgaaag cctgtttaag ttgattttgc tgctcggtta catctatttt 2407141 ttgtccatga caccgcttat taaaagagtg tttcaatatc atggagccga acataaagtc 2407201 ataaactgtt atgaacagaa tttgccaatt actgtggaga atgtccaaaa ccaatctcgg 2407261 cttcattacc gctgcggatc aagctttatt ttatttacga ttattgtcgg catgtttgtt 2407321 tatttactcg ttccgacaga tccgctttgg ctgcgtgtta tagatcgtgt cgcactgata 2407381 ccggtcgtgc ttggtatatc ctttgaagtt ctgcagctga caaacaaagt gcgtgacatt 2407441 cccggtctga aattacttgg gtacccggga ctttggcttc agctgttaac cacaaaggaa 2407501 cctaaggatg aacaggttga agttgccatc gaaagcttta acgaacttct cagactcgaa 2407561 gcattgtctg agcaaaatca gaagccttct cacaacgtca tctaaaatcc gttgccctgc 2407621 tattactttc ggaggtggac agttatgaat catcgtgtac aacctattat tgctgtatta 2407681 attgcgctgg gagcgttcgg tttcctctat gtgctggtaa ccaatcccgg agaaatggca 2407741 aaaatggcgg taaccgtcat cgtggcaggt atcattattt attttattgt gaaatatgta 2407801 atgaatcgaa atgcgggcag cgaaggagca gccttcaaaa aagcggcgaa acaatcacgg 2407861 cgccggatga aagaacaaaa agcaaaacac cgcgccggac ataagggacg tgtcagccac 2407921 ctgcgaagcg ttccgagcgc cagcaagcct aagccgatga ttctcaagaa aaaaagccag 2407981 actcagctga ctgttataga agggaaaaaa aataaaaaga aaaacagagc gcttttttaa 2408041 taggtccact gctttaaaaa cagctctgtc cgtcttttac ctagctcaat cagggctagt 2408101 tttttttgtt gtgttaaatg aaaatcagtg gccattacgt catcaacagg gagaaaaatg 2408161 atattttgtt catagcgtga cgcaatgtgc cttgcgtcat gagcatcctt catcgtttca 2408221 aacagggcgc cgaacagttc aaaagcgttg cggatatttt ttttcggacg ctctctttca 2408281 cgcggcgcaa gcgtgacacc gatcacaggg cgctttcttt cctttgaaaa cagccagatt 2408341 ggaaaattgc ttaacacgcc tccgtcgaca accgtggcgg tgcctgtgtc cgtttttaat 2408401 tttatcggtt caaagaaata cggaatgctg cagctcattc tgaccgctct ggcaaccggg 2408461 aacatatctg gatttaaccc gtaacgggcc aaatcgtccg gcaaaacaat catggtgccg 2408521 tttgtcagat cagaagcaat aaggcgcaga gaccctttct gcaaatcgcc gaaaaccctt 2408581 atgcctttcg ctcttaacag atcagcaatc catttttcta tcgtatcgcc tttgtataag 2408641 ccaagacgcc agtagatgga cacccactgg agcatcttta aggggagaaa tgagtacctc 2408701 tgatccagca atttctctcc gtccacttct tcaattaaag cgtggatttc cttactggtg 2408761 taacctgacg caatgaaagc ggcaataatg gcgccggcgc ttgtacccgc aactctttta 2408821 aagcggaagc ctttttcctc aagcacttca taagcgcctg cgagcgcaat gccttttact 2408881 cctccgccgg aaaacacacc gtcaatatac atctcattcc ctccccctcc atccgatcgt 2408941 ttattaccat tttaagaaaa cacgcgaaga aatagaccaa cgaatgacgg gtggcgtcag 2409001 cgtatcaaaa aagacggcct ccttcgagac cgccttttta ctgattatga tgttctgttt 2409061 tcttttggat tgatttcaga tcttttttac gggcatcatc ttcttcaaaa tattgaacaa 2409121 gatccccgat gcgatcaata ctgttccagc ttaaatgatg ttcgattcct tcgacatcgt 2409181 tatatatttt ctcttcatca acaccaatga ttcttaaaaa ctgctcaagc aattcatgtc 2409241 tgtataccag ccgtttgcct atttttttcc ctttagacgt taacacgaga ccgcgatatt 2409301 tttcataaat taaatattcg tctttatcta gtttttgaac catttttgtt acagaggagg 2409361 gatggactgc caatgcttcc gcgatatcgg aaactcgtgc atatcctttt tcttcaatca 2409421 gcatataaat ctgttcaata taatcttcca tacttggtgt tgtcatcgaa accctcccaa 2409481 aaagcacctt aactttataa accattacaa gtttacacta atgaacttga aaaaacaagg 2409541 atgctccgcg ggtcaaaagc cctgtttacc gcttataatt ccattcatct gaagcgtact 2409601 ttgtttcagc caagtgatga acaaaatcaa gctcttcctg agaaagttca tatggctcca 2409661 aatgaatgtt aagacctgtt tcaaatcctt ctttaaaggc tttacgagcc tcatccatcg 2409721 tcacccgctt ttcgatgagt tcattaatgg caaccgcttt atttttgaaa ttgcgctgca 2409781 tccgctctct tactctttca cttggatata agaacagatc gaacagcttg tcctcatcta 2409841 aatcaagaag aatggagcca tgctgaagaa tcacaccttt ttgtctcgtt tgcgcgcttc 2409901 ccgccacctt gcgcccctca accactagtt cataccacga aggcgcgtca aaacaaacag 2409961 atgaccgcgg attttttaag ctttcttttt ctttttcagt tctcgggatg gcaaagtaag 2410021 cgtccagacc gagatttcta aagccttgaa gtatgccttc tgaaataacc cggtaagcct 2410081 cagtaacagt cgccggcatc tcggggtgct cttccgaaac aattacgctg tatgtcagtt 2410141 cctgatcgtg cagcacacct ctcccgccgg tcgggcgtct gacgaatccg agattatatt 2410201 tatgtactgc ttcaaaattg atttcctttt taatattttg aaaataccct acagaaagtg 2410261 tcgccggatt ccagccgtaa aaacggataa ccggggggat tttcttttcg ctgtgccaat 2410321 ataaaagcgc ttcatcaagc gccatattga atgcaggact tgcattgcct gagtctataa 2410381 accgccaagt ttctttttgc attttaagac cttccttacc gttttaatag aatcagttta 2410441 tcaaactgtc gggaaaatga aaaatatttt agttccatta tagatgacaa tcacgctgtg 2410501 ctttactata atagtatttg tcgaaaacgg ctctatgacc ttgttttatg aagcagggtt 2410561 ttgattttat atgctaaagg agtagaatca cattgtctaa tatgatcgtt ttgattattt 2410621 ttgctgcatt tatcatctat atgattgctt catatgtcta tcagcagcga attatgaaaa 2410681 cacttaccga agaagaattc cgcgcgggtt accgcaaagc gcagcttatt gatgttcgtg 2410741 agccaaatga gtttgagggc ggacatattt taggcgcccg caacatcccg ctttcccagc 2410801 tgaaacagag aaaaaatgag atccgtacgg acaagcctgt ttacctgtac tgccaaaaca 2410861 gtgtccgcag cggacgcgcg gcacaaaccc tgcgcaaaaa cggctgcact gagatttaca 2410921 acctaaaagg cggctttaaa aaatggggcg gaaagattaa agcgaagaaa taaagcaaac 2410981 agctgtctgg tagacagctg tttttattta tctttcttcc gcctcgtatc tgagcactgg 2411041 gtgtctcgcc gcttttgttt catccattct ttttacaatc gttgtatgcg gggcctcctg 2411101 aacaagctcc ggattctcct ccgcttcttt tgcgatttga atcatagcat caataaacgc 2411161 gtccagtgtt tcctttgatt cggtctctgt cggctcgatc atgatgcatt cttcaacatt 2411221 aagcgggaaa taaatcgtcg gcggatgata gccgaaatca aggagccgtt ttgcaatatc 2411281 aagcgtacgc actcccagct ttttctgccg cttccctgat aatacaaatt catgcttgca 2411341 atggcggtca aacggaagat cgtaataagg cgcgagtttt ctcatcatat aattggcgtt 2411401 taacactgcg ttctcagtaa cagcctttaa tccgtcaggc cccatggagc gaatatacgt 2411461 atacgctctc acattaatgc caaagttgcc gtaatacggc ttcacacggc cgatcgcatg 2411521 agggcggtca taatcaaacg taaagcgccc ttcttttttg actaaaactg gctttggcaa 2411581 ataaggaatc agatcttgtt ttacgccgac agggcctgag ccggggcctc cgccgccatg 2411641 agggcctgtg aatgttttat gcaggttgag gtgcaccacg tcaaatccca tatcaccagg 2411701 tctcgccttg cttaaaacgg catttaaatt agcgccgtca taatacagtt tcccccccgc 2411761 ttggtgtaca atttccgcca tctctgtaat ctgctcctca aacaagccga gcgtgttcgg 2411821 attcgtcagc ataagagctg cagtttcttc attcactgct ctttttaaat cctctaaatc 2411881 aacaagccct ttttcattcg atttcaccgt aacggtttca aagcctgcta ctgttgctga 2411941 tgcaggattc gtcccatgcg cggaatcagg gacaatgacc ttcgtccgct tgaaatcccc 2412001 gcgagcttca tgataggcac ggatcatcat cagccccgtc cattcgccgt gcgctccggc 2412061 agcaggctga agcgtaacct catccattcc cgttatttct tcaaggtgtt tgcttaaatc 2412121 atataaaagc tctaatgcgc cttgcaccgt gtcttcatcc tgaagaggat gaatcgcagc 2412181 aaaaccagga atacgtgcga ttttttcatt gattttcgga ttatatttca tcgtgcaaga 2412241 accgagagga taaaaaccgg aatccacccc gtgattgcgt ttggacagcg ctgtataatg 2412301 gcgcatgatg tccagctctg aaacctccgg cagcgctgcg tcttcgtcac gaatataggt 2412361 gtctgacaag aggtccccca attcgatttc cggtacatcg agctccggca gactatagcc 2412421 gattcggcct tctcttgaaa gttcaaaaat aagtgcctgg tcctgattac tcatggcgat 2412481 cccccaattc ctgaatgagt gcgtcaattt cttcttttgt tctcagctct gttacagcaa 2412541 tcagcatatg gcagtccagc tctggatacg tcaacccaag atcatatccg ccaatcatgc 2412601 cttttgccag caaacgcttg ttcacagctc tcaccggctc atccagtttg atgacaaatt 2412661 cattaaacat cggcccgtca aacataacag taaggcctgc tttttttgct tcttgctttg 2412721 catagttggc ttttaagaga ttttggcggg ctatatcttt tacgccgttt tttccgagag 2412781 cagtcatggc cactgatgct gccagcgcat ttaaagcttg gttcgagcat atatttgatg 2412841 ttgctttatc ccggcggata tgctgctccc tggcttgcag ggtaagcaca aagcctcttt 2412901 ttccgttttc gtcttccgtt tgtccgacga gacggcccgg cacctttctc attaattttt 2412961 tagtaacggc aaaaaagccg caatgcgggc cgccgtatgc tgaaggaatg ccgaaaggct 2413021 gcgcatcacc gacgacgata tcagactgaa acttgcccgg cggagtgaga agacctagcg 2413081 ccagcgggtt ggctgaaaca ataaacatgg atttcccttg atgagcgata ggctcaatat 2413141 cctttagcgg ctcgatcctg ccgaaaaaat tcgggtactg aacgatcact gcggctgtgt 2413201 tctcgcaaac ggtttggcgc aatgcatcaa gatccgtaac gccatccgca gcgggtactt 2413261 caacaacatc aatatactga ccttttgcgt aagttttcag cacctctcgc gattcaggat 2413321 gcacggtttt tgacacaaca atttttttct ttttcgtgtg gcctgaagca agcattgctg 2413381 cttctgccaa ggctgttccg ccgtcataca tcgaggagtt ggcgatatcc atgcctgtca 2413441 gttcacagat catcgtttgg aattcaaaaa tagcctggag ctctccttgt gaaatctctg 2413501 gctgataagg cgtatatgcg gtataaaact cagagcgcga aatgacatga tccacaatga 2413561 caggctgata gtggtcatat acacccgctc ctaagaaaga agcgtattgt acggtatcac 2413621 gatttttaga ggccagcttt gtcagttctc ttgttaattc tgtctctgat ttcgcttttt 2413681 tgatttgatg ctctttttta tatttgacgt tttccggtat atcagcaaat aaatcatcga 2413741 tgctgcttac gccgatagta gcaagcatct cctgtttatc cttttctgtt gcgggcaaat 2413801 aacggtgctt catgtgttgt ctcctctctc caagaaaaaa tattagcgtt tataaaatgg 2413861 tgttttgaca acctttgctt tcactaattt tttgcgtatc tctacatcta caacagtccc 2413921 gatctcactc gtttccgaat caattaaggc aaggccgacg ttttttccta atgtcggtga 2413981 ctgcgtgccg gttgtcacct ttccgacaga cttgccattt tggaaaacct catatccgtg 2414041 ccgcggtatc cctttttcaa tcatttcgag accgacaagt ttgcgcttcg ctccgttttc 2414101 tttttgttca ctcaatactg acttaccgaa aaagtcagac tcctttttgt gctttacagc 2414161 aaagcctata cctgcttcaa tcggtgtaat atcccgggtc agctcctgac cgtagagcgg 2414221 gagcttcgct tcaaaccgga gtgtatcacg tgcaccgaga ccgcatggaa tcaatccgta 2414281 tgcatcccct gcatcgatga tttttttcca aatatgcata gcatcatcac tgcggcagta 2414341 aatttcatac ccgtcttctc ccgtatagcc agtgcgtgaa ataagtgctt tgcggccgct 2414401 gatatcggct tcatcaataa acgcaaacgg ctttaatgca gacacatccg catctgtcag 2414461 attttttaag atcgcttctg ctttcggtcc ctgtacagcc aagagcgcga tttgatctga 2414521 ctgattgtca atctgcacat cacctgctgc atgttctttc atccaagcca agtctttatc 2414581 tatattagaa gcattaatga caagcagata gcggttctct cctttttgat agataagcaa 2414641 atcatcgacg gttccgccat ccgggtaaca catcgctgta tattgagcac ggcctggcgt 2414701 taacgcggaa acatcatttg tcatcaatct ttgcaaaaaa gacagactgt cgttccctga 2414761 cacttcgact tctcccatat gagatacatc aaacaaaccg gctgcagttc ggacagcctc 2414821 gtgttctttt tttatagaag aaaattgaac aggaagctcc cagcctccga aatcaatcgt 2414881 ttttcctcca tattccttat acaggtcaaa taacggcgtt cttttcagca tctaattcct 2414941 cccctttatc aacggcgcag ctaaaaaaca tacaaaaaag gacagagaaa cacctcatgt 2415001 aaaatgaagg ttctctgtcc tggcacctga aagtttactt tgcatacgca aagacgtccc 2415061 ctttggtggt ttgcgcatcc gcacaaacac tctccagagt tgcgtcgagc aagagttctt 2415121 ttgcctgaga gattcactcc gcagtttgct ccttcggcgc ctgtatcccg aggttttcgg 2415181 tcaggtctct ccccttgctg tcattcgctc atattttcat gctgttatgg acatactata 2415241 gcaatatctt acatcaaata catactcata tcctaccatc atcactatat gctgggcaac 2415301 agcaatttgg gcagattttt cttatattat tcatcttaag aatcgaagaa taagaaaggc 2415361 ggtttcaaag caatgaatac agaaatgatc tacgatgcaa aatggcctga agaatttgct 2415421 gaaagactga aaaacgatgg cccttgggca aactgggaac tgtacaagct ctctgcagaa 2415481 atccagaaaa cattagcaat tccagagttt gaaggcttac gggctccttt atatctgcct 2415541 tcctttacgc cgctccccca ccagcttgaa gtggcgcaaa aagtggttga aaaaatgaac 2415601 gggaaagcga ttttagcaga tgaggttggt ctcggaaaaa cggttgaagc tggactgatt 2415661 ctaaaagaat atatgattcg cgggttagca aaaaaaattt tgatccttgt gcccgcttcc 2415721 cttgtgtcac agtgggtcaa agagcttcag gaaaaatttt tgattccggc tgttgaacaa 2415781 aagaaaagct atgtgtggga gcaatgcgat attgtcgtct catcaataga caccgcgaag 2415841 cgctcgcccc atcgagaaat cgttctgtct atcccatatg atcttgtcat tattgatgag 2415901 gcacacaaac tgaaaaatag caaaacgaag aactatgaat ttgtccggaa tctcgtaaaa 2415961 aaatattgcc tgcttcttac cgcgacgcca atccagaacc gtatcgaaga gattttcaat 2416021 ttggtgtcct tattaaaacc cggccattta ggcagtcaga atcactttca ggaggagttc 2416081 gccaagaaga aatccagttt agaagcgcat gaacatttaa aagatcttgt gaataaagtc 2416141 atgatccgta acaggcggca tgatacaggg ctgaattgga aacagcgcca tgttgaaaca 2416201 gtgccgattc aattttctcc atcagagcag gcgctttatg atgaaatttc tcgtttgaag 2416261 gacagtatca ataaaccagc cagcatgttc tcgattatga ccttgcaaag agaatgctgt 2416321 tcgagcagag aagcggtata tatgacgctg aaaaagatgc ttgatcaaaa agagaaacaa 2416381 gcacctgcca ttgatgagga tacgatttca gttttgatag atcgcatcaa tcaagtgaca 2416441 caaaactcta aagcgcttca agttgttgac ttgatcaaaa agatcgacga taaggtcatc 2416501 atttttacag aataccgcgc aacccagatt tatctgcagt ggtttcttca gcaaaacggc 2416561 atcagttctg tgccgtttag aggcggattt aaacgtggaa aaaaagactg gatgaaggat 2416621 cttttccgcg gaaaaatcca agtccttatt gcaactgaag caggcggtga gggaattaac 2416681 ctgcaatttt gcaatcacat gatcaactat gacctgccat ggaacccgat gcggcttgag 2416741 caaagaatcg gaagaattca cagactcggg caggagcgtg acgtgcatat ttataacatg 2416801 gcgacaaaac atacggtgga agagcatatt ctaaagcttt tatatgaaaa aattcatttg 2416861 tttgaaaaag tggtcggtga acttgatgat attttaacga aaattcaagt gaacaatttt 2416921 gaagagcacc ttcatgacat tttgtatcac tcagcaacag aagaagaaat gaaaataaaa 2416981 atggataact taacctcatt tttgtcttat aaaaaacagc tgcctgctga aaaaagagga 2417041 tcttagcctg taaggaggtt ttattagtga gacagcaaga ggttcacgat tttctgctgc 2417101 gtttttttca agcaaacagc tgccaaatcg tcgatcaagg cttaggctat atgacagtgc 2417161 agcttacagt tgaaatggac aaacaaatca tgaaccgccc tttctactgg cattggcgcg 2417221 agaagacagg cggtgatccg aatccaatga aaatcacttt tattacagat aaagaaaatg 2417281 cgccaaaaga cctagatggt gaatttatat attttggggc cccgcgtctt tttcaaatat 2417341 tcaaagctgt taaacaaaat gggagattta ccagaatgta tgagaaaatt gaatcagccg 2417401 gagctaaagt cccacttcag ccttggcttg gtataaatgt cacgatttca taccagtccg 2417461 acatgaaaaa ggataagtta ttgtcactag gtcttcacct agtctctgga acgataattg 2417521 aagattttca aagcaagctg acccagtttt cactgacgtc tcaaatatgt gactattgct 2417581 tcaccatttc acctatgatc aaaccagaaa gcggacttaa gcgtatggaa aactatattt 2417641 ccaaatccgc tatgcaggag ccgtccgact gggcggaaca ggcggttaac aggtggaaga 2417701 atgatatgac attgcttgat aagttttacg agcatataga agaaaaacca gaagaatacc 2417761 atctagaaaa acaggcgctg aaaaccttgt atcaaccaaa gatatcagtt gaaattgaaa 2417821 atggcggatt gttttatctg caaaataata tttcaagcta acttttttac cattcgacat 2417881 cattctcgtt ttttttgaga aaatacgatt ataataaagg tatattggaa aaaaattctg 2417941 gtgatttaat ggcaaatgac ttccagagac taatgaagca tacaataagt catggccgga 2418001 ctggctgaaa tacataaaca agtattttag gaggagaaac tgcatgaaga atgcaaaaca 2418061 agagcacttt gaattggatc aagaatgggt tgaattaatg gtggaagcca aagaggcaaa 2418121 tatcagcccg gaagaaatac gaaaatattt acttttaaac aaaaagtctg ctcatcctgg 2418181 tccggcagcc agaagtcata ccgtaaatcc tttctgaatg tgctataata tcacaaggaa 2418241 ggtgatgaca ttgattggcc agcgtattaa acaataccgt aaagaaaaag gctactcact 2418301 atcagaacta gctgaaaaag ctggggtagc gaagtcttat ttaagctcaa tagaacgaaa 2418361 tctacaaacg aacccctcca ttcaatttct cgaaaaagtc tccgctgttc tggacgtctc 2418421 ggttcatact ttgctcgatg agaaacatga aaccgaatac gatggtcaat tagatagtga 2418481 atgggagaaa ttggttcgcg atgcgatgac atccggggta tcgaaaaaac aatttcgtga 2418541 atttttagat tatcaaaaat ggagaaaatc ccaaaaagag gagtagtgcc tgagcagagg 2418601 cactaactcc tcttttgtca ataaccatcg agacggccca gtatatgaat actgggccgt 2418661 ctcttttttt tgctgttatt aatttttatc ctcgctatgc gctttttcat tttctttcac 2418721 gtaaccatct ttatcagtat ggtccttttt gattgtcaag ccgttccact gtgtagcttc 2418781 gaatgagaat tgaagcttaa tggagttgcc ttgatattta ttttgaacca taagcccttt 2418841 ttcatctttt gttttatcat ccttgaattg gatttccatt tgaacctgat cgaagtcagt 2418901 tggtgttttt ggaacaccat catattcagg agcggtttta ccatcaattg ttgctacatt 2418961 gactttaccg cttgcattta agaatttagg gtcaatttgt tttttgattt tttcagcagc 2419021 cgctgcatca tttttagcag acatcaaata caagtcttta aggttcgcat catctaaaat 2419081 aatgtttttc gggtagccat tgccgccctc ttttccaact gtcaacaatg tcacttcaaa 2419141 ctggctgagg aaatcttctg gagatgtatt gctgccgccg tttgctttaa aatctccata 2419201 attaagcgcc attagaactt ctttgatcgc aagtgatccg ttattttcaa attggaaatc 2419261 ctttgtcaac ttatctcccg gctttagatt tgataagttc acactcgctg aattctcttt 2419321 agcagataaa tcaagcgtac ctgatgcaaa agtagcatcc tttgatttaa tgtcgttaaa 2419381 tgctgcccat gttcctcctc caactaaagc taatcctagt gctgcagaag caactcctaa 2419441 actcaatttc tttttcatac ccatggtaag ctcccctttt attgaatgat tttatatcga 2419501 aacctgttgc caggtttaca actgaagtta agtagacatg gtgctgtcct ttgtatctgt 2419561 ttccaaggct tttgtctttc tttcaatttc tctaatggcg ctgctgatcg tcacaaaagc 2419621 gtaaactaac agcatcacgc cgggaacaat caataataca gccgttccaa tcggctggct 2419681 ggcaaaatga agcatatagc cggcatatgg aagctgaaaa cctgtgtatt gcgcgcgaac 2419741 attttcgtcc gatacaggcg ctgaatcagc tgctgcatta ttatcacctt ttgttttaaa 2419801 taacaaatgg tctccttgct ttgttatgtc aacaattctg tgggtgaccg ccgtatttgc 2419861 atcctgcata aatgtaataa cgtcaccttt ttggagctct ttcacatcag tgatttcttt 2419921 gaccaatatt aaggaacctg tattgaactc cggctccatc gaacctgaca gaactgattt 2419981 cagcgtatac ccaaacactg ccggctctcc cccggatgaa cgtgttgaaa tcacgacaag 2420041 tgtcagcaca ataataagag taaagatgat cacgtataaa atattactga tcagcttcat 2420101 tgcttttttc atcctcttcc ccgctttcct tctggtctga ttgagtttct ttttctttgg 2420161 ttacagcttc ttgagatgtt tcttctttca ttgttttttc cggtatatct ttttgtgttg 2420221 tttcattctc ctttttgacg tccgactttg tttctttttt agggactgtc ggtttttcat 2420281 cgcattttgc aagcctcata ggctccgacc actcaaatgt actgccgttt gccgggtagc 2420341 ctgccggttt atatacttta aatgcataaa tgccgggttt catttttttc ttggtctcaa 2420401 ttttataaag tgaatcgccg atttgattgg agacaaatcc tttttcgatc acgttcccat 2420461 cctttaacgg tttgcgggca ttttcaagct tatgaagctc ccacttccac tttgatttct 2420521 taagtttctc acctgtattt tcgagcacag caaataaggc gaaaggtgag catacagtgc 2420581 ctttcgtatc cgtttgatct gatatgtgca aatcactttg atcccagcgt ttatcataat 2420641 ggcagttttt atctgtatgc tgaaagtctt tacacgtttg aagtgagaca tcaaatgttt 2420701 caatatcatg aaaagcagcg cttgtatcat cggaaaattg taagcatatt gcggcagtca 2420761 gactgaaaat gactgaaagc tgaaagataa gcagaacttt cagtttcgtc ttcgcctttt 2420821 gctgattgtg aaacaatcga aacatatctt acctcctgta aaacactgta acttgatatg 2420881 acaatcgttc tctttaaaga acttcacaaa tagagtataa tcaacgattt atagatttaa 2420941 aaacaccgaa atcgctcatt ttgttcgttt aaaagaatgt tttcatcata ttacaaagtc 2421001 ttgctcagta ttgctcattt tttcaatttt ttagaaattt ttgggattgt tatgtgagaa 2421061 tttaaatgca tatcccatta ttatttggta ataataaaca aagaaagggt gacagcatga 2421121 tgatcaaaca atgtgtgatt tgtctatctc ttctcgtctt tggcaccaca gccgctcacg 2421181 cagaagaaac accgcttgta accgcccgcc acatgtccaa atgggaagag attgctgtaa 2421241 aagaagcaaa aaaaaggtac ccgctcgcac aggtactgtt caaacaaaaa gtatgggacc 2421301 gtaaaagaaa agatgaagca gtgaagcaat accatttaac tctgagggaa gggtcaaaag 2421361 aattcggcgt ttttgtgacg atttcatttg atccttatag ccaaaaggtc aataaaattg 2421421 ccatattaga agaatatcaa taaggtcctc cattttttga aggaccttat tcgtttattt 2421481 gcggttattt tttccgtttc agccaaagtc ggaagccata gggtaaaata ccgaaccact 2421541 gctgggaaac aggcgttttt gtttctttcc gcacctcttt tcgttctttt cgctcatctc 2421601 tcggagtatc tatatatttg acaaattgct gcgtcatata tttaacataa tcattcgttt 2421661 tcacgtgatc acctcatcat tcaattatta tgagtgttgt ctcacatgac tttttttata 2421721 ccctttacac tgttttattc tgtccatctc agcagttttt tctgtttttg gtcaaacacg 2421781 atctgtgcag ttctttctgt tcccgaatcc gttgacactc ttaagttgat ttctttttgt 2421841 tcttttatcg atgtatcatg aatgtaataa gaaacccgtc catatagaaa ttgctgcgta 2421901 ccctcctggc ctttccgttc ctctagaaca tgccgaatcg aaagaagcac cccattttga 2421961 agcaaattct ctcctatgta taactctttt gtttccttct caaacatgca gcgtgaaata 2422021 tattgagcag caacaaagtt cacgattaac agcacaagcg ctgacacaaa aagaacagct 2422081 ggataaataa accctcttgt acgatacatt cacccccctc ctaaatacga atagactgga 2422141 aaagcagttt gatacacttt ttggtcttca ctctcaattt tcagcaaaac aacaccattt 2422201 tcaatatcag ctttcatggc agtaatatga tctaaaatcg gaacatgccc tttgccatcc 2422261 actctttttc ttatcattga atgataaatg tcaaaacgga tgtcttgtcc ggaaagattg 2422321 gtgcagatta acacgctccc atgctcggct gtcttaactg cctgtgattc cttgcattca 2422381 ttcatcatct gttctatcga aatcatccat tcctgctgtg tgaaaccgtc atgttcctgc 2422441 tgtcgagaca aaaacagatg gataatcgca gctaacgatc ctgatatgag caaaaagact 2422501 gagagcgaaa ataatacgtt aagaagcgtg tagccattct gtctgcaaaa tgctgaggca 2422561 aaatgatttt tctttataag ctgcggcttt gatacatacg ttttgatatt cgccctcctc 2422621 ctcccacttc attgcataga tatgattgtt ctttgtaatc gtttttgacg cggctccttc 2422681 accactcatg acatatttgc taatgctctc attcatcatc tgatagccaa tttctcgtga 2422741 ttccgccatt ttttcatcag ccatcagctt gtcccacaag gggacgactg tcagcagcac 2422801 aaacagccac aggcttagcg cagacattgt ttctattgta gaaaaacctt tattttctct 2422861 ccacattgac tctcccgctc cctagataaa ctgttatgtc ataaacggca tggcctttta 2422921 ctcgtatttt tccgcctgca ttcgggtgcc ctttctcatt aaattccaaa cggtctttta 2422981 atgtcagcag ttctatagaa agtcccgttg catacggacg ttcaataacc gtatcaccaa 2423041 tgactaattg atattctttt ttatgaaaga gaatttttgt tctttgttga cgggaaatag 2423101 cagtctgctg tgtgagcata atatcatttt tcagctgact tgctgcctgt cggacagctg 2423161 tattgtcata agcaggagga agtgtagtga agacggccac caggaggata gaggcaaggc 2423221 ttaacacaag caaactttct aaaagggtaa accccttctc ctcgtttaat ttaatgttca 2423281 accttaactt ctccgccggt gatgataatg cgcttaccat ttggacagac agcatccttt 2423341 ttcacatagc cctctgactg taaatcggca aggctcggag tttgtccttc atgatcaagc 2423401 tcaaatgcag tcatttgtgc cttaaccatg ttttgtaagc cttcacagcc ctttttttga 2423461 atggtttgat tatgtttcgt gacgttcggt atcgtaatta aaagcaaaat cgaaataata 2423521 aagagcacga ttaacatttc aacaagtgta aatcctttct cattcatcag cctcttcctt 2423581 tcacatttga ttcatcatct gatacatagg cacaagcata gataaataca caagtaagat 2423641 catcgctgca acaaatccat aaatcattgg ctgaaggatg cctgtccatt tttgcgcttt 2423701 gtgttccagc cgctgtaata tgaattggct gtatgtgaaa agctcccgat ccaatcggcc 2423761 gctcagctgg ccgtgagata tgacttttga taaatcagtt tcataaaaaa ggcttccaca 2423821 aatagcggat tcaattgact caccggcttt tagccgttca atcaattgtt cagcctcgca 2423881 gcggtagaaa gggagaaacg tttgatgttt aaatgcatta aggctgtcat aaattgagag 2423941 gcctgatttt aaaaggctgc ttagctgcaa agaaaaaaag tagctgttaa acagctttac 2424001 aagctttcca accaaaggaa tcctgataca aatcagcatt tgccgggcag gtgatttttt 2424061 cttaaacaca agccaataat aaatcccgat acctgctgta aaaagaacaa gcaaaatgat 2424121 cacaagatca atatgctgaa aaaaagcaaa aagcatatcg gttgaacgtg aggtttccat 2424181 attcatcgat tgatagatac cggaaaactg aggaatgatg atggactgta acatataaaa 2424241 catgacagcg accgtaaaga tgaggaaaag cggatagcgc agcactcttt tcagctggtc 2424301 tgcctgtgca atttttcgtt ccagcagctc tccgctctgg atcattgaag caggcagttc 2424361 accatgtgtt tcagcaaaat aacaaatacc tacggcttcc ttatgaaatg acaaactctt 2424421 tagtacttga taaaacggag ccccttccct caaacaagtg accgaatcag tcaagtcagc 2424481 cgcctgcctc ttattcatct gaagttccat caggcgtaat ccatccagaa gtgtatatcc 2424541 gcccgcagtc atttcaccga gcctctttaa taacctggct tgatccttta acaaccagac 2424601 ttttctaatc tttttcatga taaacccacc ggtcatagtt gtttgtcgtt aaatagccga 2424661 gcgcaattcc ttttctgata atttgacgaa gcgtttgata ttggtaattt gcatgatttc 2424721 cttttgcctc ctggatacat tgctgaagat ttttcccgta tagaagctca taaacgctag 2424781 ctctcctagt atttcgtgac tgtcggcaat acactgatga acatccgttt tcacaaaacg 2424841 ggcaagccaa atcaaccaag cgctgagccg ctattgcaat gacagtctgt tcgatttcat 2424901 tcatattgat accgaattca agcagtctgt aaattgcgcc ctttgcgtct ctcgtatgaa 2424961 ggctcgttag taccagatgt cccgtcatcg ctgcccgcac cgcaatttca gctgtttccg 2425021 cgtctctgat ctcacctaaa ataatcatat cggggtcatg gcgcaaaatt gctttcagac 2425081 ctgcggaata agttacaccg gctttttcat tcacctgaac ctgaagaaca tcttcgtccc 2425141 ttgtttcaac agggtcctct aatgtgacaa tatttcgatt aaagtgtttt tttgcatatt 2425201 gaacgagaga gtataatgtg gtagtcttcc ctgaaccagt cggcccggta aaaatgagca 2425261 tgccatggga atgttttaaa aacgagagta atgtggctcc tgtcttcgga aatagcgaca 2425321 atttatcaat cgaagggata ttgtattggg gcatcactct gatcacgagg ctttcttcat 2425381 taattgtggg cagcgttgac attcttaaat gaacatttcc ctctttcaac tttaacgtaa 2425441 gcgaaccgtt ttgcggcttt cgcctttcac ctatatccat tgctgaaaga aatttaaaat 2425501 gtgaaatcag tcttacgcac tcttcttttt tcatgtccct ttttttcagc aaggcatgat 2425561 cgacccgaaa atgaatgata gcgtcccgct ccctcggcac aatgtgaata tcagaagcct 2425621 ttgttagata tgcctcttca atcaagtttt tgcttacctt ttctattgaa tccaatttga 2425681 ttccctctcc tttcaacgca tattgtagaa aaagaagaaa aggtaatcaa acagggaaaa 2425741 cgtgattttg tgagatgtta tatgctgaaa aaccaattct ttctggcaag aaaaaagact 2425801 ttcaactgaa tgtacccctg tcattataat tttccctata aataaaaaag cagacatggt 2425861 caccatgcct gctagattcc attttcatta tgctgttttc gcttattgac cagtatcttt 2425921 ctcaacggaa agatcgccta atgcaacaat accggtcatt tggtcatttt caagaatcga 2425981 taaactgcgg atttaatgct ctgtcataag ccccttgaca tcgtatccgg tcaccctgat 2426041 atgtctggtg aaaaagcggg gcacgctgca caaaatatga aacatcctat agagtccgcc 2426101 tttttcgagg tttctttttc ttcttccgct cctgcagcat atctcccgtc cagccttttt 2426161 ttctcaaata gagatagatc agaactgtag atgtgacaat caataagagg gaaaagagat 2426221 atccgtattt ccaattcagt tccggcatca ctgaaaagtt catcccccat aaggcaccca 2426281 gagctgtaat cggagtaaaa agcgtcgtga aaatggtcag cgcttttaca atttcattcc 2426341 ccctatgtga ggtaatgact tcctctgaat gcagcagatt gttaagctcc ccttcaaatt 2426401 cgctgatgta tgtaaatccc ctgtcaatct tcagttgtgt ccgctgataa tcctttttcc 2426461 cttcattttg aggtaaaaag gtttctttca acgccatttc aattttttta gcgcttaata 2426521 tcaaattttt ccaaatcatc agttcatggc gcaggagatg gacgcggttt aaaatgcttt 2426581 tgctattgtc gtctttaatt tgccatctga gctttctcag cttgacttca aattcatcaa 2426641 caccgattaa atacgcattc attagttcgc cgagaagaat taaaaacccc tctatcgcat 2426701 tgtccgctct ttccatttgc cgaacaactt ctttgccttt aatctctctc aaaattgaaa 2426761 agtcaaagtt gattgtaaaa aaatattgtc tggtgatata aaagtgaaaa acagtatggt 2426821 ctttttcttc accaagcccc tgatcataaa caatcgaccc aaatactgct tcattttccg 2426881 tttcagttgt atctactcgc aaaaaattaa cgtgatggtt attttcaaac cacttttcac 2426941 actgaggcca gtgagaaaaa tggattagat ctcttgcctt acttctttct tgaggcccca 2427001 tttggtacca aaaccaatcc tttcccgtat gtgccttcat gtcaagctcc tccaaacttt 2427061 tgttctttat tctttaattg cccaataacc gcgtcactaa accagtctgc cgcttcaaca 2427121 catgttttat gagcattttc aggtggtatg gaatgtagaa agacatcgga aaagggaggt 2427181 gcatgccttc cttggagaag gcagttgttt tggaatttat caatttacta gcagtcgcta 2427241 ttctcatttt gttaacagga tttttcgttg ccgtagaatt ttcaatcgta aaagtgcggc 2427301 gatccaaaat tgatcagctt gtcgcaaaag gaaagaaagg tgctaaagcg gcaaagcatg 2427361 tcatcactca ccttgatgaa tatttatcag cctgtcagct gggcatcaca gtcgcagctt 2427421 taggactggg atggcttggg gaaccgactg tgcaaactct gcttcgaccg ctttttcata 2427481 aagcaggctt aaatgaatcg cttacccacc tgctttcact cgtcatcgca tttttagtgg 2427541 ttacgtattt aaatgtcgtt attggggagc tggcgccaaa gagtttcgcc attcaaaaag 2427601 cagaaagcat taccttgttg ttcgctaaac cgcttatttg gttttataag atcatgtttc 2427661 cattcatttg gctgttgaac cactctgccc gattgattac aggagtgttt gggctgaagc 2427721 cggcatcaga gcatgagctg gcttatacag aggaagaact tcgggtccta ttggctgaaa 2427781 gctataaaag cggcgagatc agaaaaagtg aattaaagta catgaataat atcttcacct 2427841 ttgataaacg aatggcaaag gaaattatgg tgccgcgaaa tgaaatggtt agtttgtcac 2427901 tagatgaaga ctccatttca aatcttcagg aaacagtcaa gcaaacaaaa tatacacggt 2427961 acccggttgt aagagaggat aaagataacg tcattggcgt gattaatatg aaagaagtgc 2428021 tgttttccat gctgacgaaa gatttttcaa tcaagaagca tcaaattgaa cctttcgtac 2428081 agcccgttat ccatgtaatt gagacgattc ctatttataa actattgctg aaaatgcaaa 2428141 aggaacgcac tcatatggcg atcctcatag atgaatatgg cgggacgtcc ggtttggtca 2428201 ctgtcgagga tattatcgaa gaaattgtag gagaaatccg tgatgaattt gatgcggatg 2428261 aagtgcctca tatccgcgaa cttggaaagg atcattactt gttaaatgca aaattattaa 2428321 tcagcgatgt taacagcctg cttggaaccg atttatcaga ggctgaagta gacaccttgg 2428381 gcggctggtt tttgacacaa aacatagacg ctgagcctga aagtgccata gaatatgatg 2428441 gctactcttt taaggtaaaa gacatcaaca gccatcacat tttatttata gaagttaaaa 2428501 aagctgaata gcccgtgaaa ggctgttcag ctgctatctt tcaagataaa catggcaaag 2428561 gcatcaacac tcttttattt taaacccttt attggccagg gctttagcaa gactttgctc 2428621 tgttttcaca ttcgaaaaat ccagacccag cttcacgaca gtttgggcaa tttccggcct 2428681 gattcctgaa ataatagtct caatgccgag caatttggtg ctgtcaatca ctttaaaaat 2428741 ttgataggct accatggtat caacgatagg aacgcccgaa atatctaaaa ataaatacga 2428801 gagctttaac gctgagcact gctccagcac agactccaaa atcgtcctcg ctctgtgcgt 2428861 atcaatttca ccgacaagcg gaagaatccc aattccatca gtaatcggca taatcggcgc 2428921 actcaattca ttaatcattt ctttttgcgc gtttaattgt atcatggtca cctggtgata 2428981 ttcttccgta aacacttcga tgatctcatc aatgttttga ttcaagatcc ggctccactc 2429041 ataaaattcc tgaatgctga tgtcttgaga agaagcttcg ctgaatttat gaatccattc 2429101 aaacatgatg tgcctgaaag tgttaaactg gccgacactt tgtgtaaccg tcacttcatg 2429161 aacggcacgg tctctggcgc attgaagaga ccaccggttg agctcatcct ctacgtcttc 2429221 ttttctaagg gattttgcta cgatggtcac caataattca tgctggtctt ttaacttttg 2429281 ttctagtttt tgctgatctt tcgctgaata cagccagctg ccgtttgacg tacaaacttc 2429341 cagccattgt tgcgtaatat cttttttgtg ctctgttaag tgctgatcaa gagctatcat 2429401 cttaatgagt tacctcctgt ttttgaaaaa tgtacgctat atatgtataa cgcgtctgcc 2429461 tttacacata ctatgtttag attcaatggg ctatagccaa gcggtaaggc aatggacttt 2429521 gactccgtga tcgttggttc gaatccagct agcccagttt ctgaacaggt gaaaaaccga 2429581 agataagctg attcgtataa atcagcggat cttcggtttt tcatcatgca gattgatgaa 2429641 ccgttttctt cttcgataac ttcaacagtt ctcccgggtt ataaccaatc accagctttt 2429701 tgttgtctac tagaatcggg cgtcgcaaaa gcttcggctt ctcgattaaa agttccagca 2429761 cctcatttac cgtcatttct tcaatgttta aatttaaatt tttgaaagtc tggcttcttg 2429821 tcgccaaaat ttcatcaatt ccttctgtcg ttaacgataa aatgtacttt aattcttctc 2429881 ttgtcggggt ttctctgaat aagtgccgtt cgttaaattc aatttgatgt gctttaagcc 2429941 aatgttttgt ttttcggcat gacgtgcagc ttggatatga gtaaaaagtt aattgttgtt 2430001 ccattcgttt tttcctcctc agttaaccat ctctttgtag aataactacc cggatcattt 2430061 ttcatttaaa ccatttacag aacttttttc ggattatttt ttaaaaaaca ttcatacaat 2430121 agaaaacaca atcaaaggga caaattccat ttgtatatta ataatgaaaa tgtttacatt 2430181 tctaggtgtg atctattata ataacagtca gagggactct cgggagggga taaaaatgaa 2430241 tcgcatgttc cgggtgttag gattttggac gggaattttt gcagtcatgt tttatttagg 2430301 tgatatgaaa gatgcttccc ttttattttt tggacagacg atcttatttg tgtttctatc 2430361 gtatttgaac ttaaccgaac gcatgtatat ttatattttt ggcgcttatt taacaatttt 2430421 cttcgccggc tttacatatt actcaatttt tattatggtg cccggcggcg gaggccatta 2430481 aatgcagaaa gagacaaacc ttatcggttt gtctcttttt ttacaatgaa aacccattta 2430541 aaaacggatt ttgatcctgc tcagtcagta cgtctgtttc aggtccatgg ccgcttaaca 2430601 ccagcgtgtg ttccggaagc gtaagcagtt tttcatgaat ggacgtcagc agcgtctctt 2430661 gattgccgcc tattaaatcc gtacgtccta taccgccttg gaacaagaca tctccggaaa 2430721 tgaccaagtc tgcatctttc acgtagtaag acacactgcc tggtgaatgt cccggcgtaa 2430781 ataatgtttc caaatgaaac ggcccgatat tcaactcacc gtcgccttca attagatgat 2430841 ctgcaggctt agctgtgact tctatccctc gcagcatgcc ggagccgttt aaagaagcgt 2430901 ccgcaagcca atttttttca ttttgatgca ggtaaacagg gatatcccat ttttctctca 2430961 cttcatcaag cgccccaata tggtcaaaat gggcatgtgt aagcaaaatg gctaaaggcg 2431021 tcagcccttt ttcttttatg tattgattga ttttatgtcc ctcgccgccc ggatcaaaaa 2431081 tcagacattg atcatcactg atgagaaaat atgcgttcgc ttgaatcggc cctactggca 2431141 ttcgtctcca tttcactatt atcacctctt tcttttttat gctcttatta tgagggtttt 2431201 tgaaaaaaga ttcaaacaat cgcaatgaaa acgctatcga caaacctata aaaaacaggt 2431261 agaataaaac tggaaagaat tgcaggtttt tcaatgtaaa gggggctgtg ttatgttact 2431321 tgtcgtgatt ttcggccttg tcgctctttt cgctttatgg ggagtcttgc gttctgttag 2431381 aaataaaaat atactcgggt ttttattagc cggtgccacc ttatttgtct ttggatggtt 2431441 taccgtgatg accgtaataa acagcgggta tccaaccgca cattaaaacc tgtatccgat 2431501 cggatacagg tttattttta tggctgtaaa tgtttattga cactttctat tttgctctca 2431561 agcgtcgttt ttttgtcacg cctgtcatcg atacggatat tcgttgccac tctgtgcaat 2431621 cctttttgaa atggcgcttc gtgaattgcc tgaataactg caaaaaggtc actgagttct 2431681 ccctcgatca gcgtattcat cggtgtcagc tgatatttga ttttcccttc tgcttgatat 2431741 ccttctaata tcttttgcac atcggctacg taagcactga cactgggtgt ttccgtaccg 2431801 attgggataa tggttacatc tgcgatagcc atcgttattc catctccttt tgatcaatga 2431861 tgagttgctt cgtttcatgt gatttcaata aaataatttg ctcaaaatga aagccgtata 2431921 acgcatattt cccgttcgga gatatttgaa tcggctccat ttcccgcaga gacacaagat 2431981 cttttgtctc tcccgatgct acattgattg ctgcgagctt atatgcatcg ccgctttgtt 2432041 tgaatgtata aaacaggcct cctgcttcat catagtcata ctccattgga gccaaacttg 2432101 tatatttcgc ttggagcggc catttcgctg taacaggtga tgttgattgc ggcgttttaa 2432161 actgatacgt cccttttcct ccggaagctg atttgacagt aaaactcatt tgatggaaag 2432221 aatcgaagaa tagaacgtta tcctcaagct tctgttccgt cttagaagct gtatcgaacg 2432281 tatataaagg ccctgtttta tcgtctctac cctcttttac ataatcaaat gtatttttgg 2432341 atgtccaatg aatgaacgga acctgtactg ggcttaagaa agattcgtct tttttagcat 2432401 tcacctgata tgtatggaaa tcccagtttt cattgaattc cgtcaccatc atttgataag 2432461 gatcatactg attccaagca gcttcaagct catacgtttc gtaatctttt tcgtaaagcg 2432521 tctctccttc tgcattaagc aaaaccactg ccgtcttttg gctatgtgtg atttgcagca 2432581 gaatcatctg ctccctcgca ttgatttgaa catcaacgat ttgaccatcc gtttgataga 2432641 gctttttcgc tttgcctgta aagatgcggt acgcaaaaag ctctgttttc gtcggattag 2432701 acgcagtata taatattgtg ctgttattca gccagccttc cgccccatcc gctttttccg 2432761 cggaaagcgg tatgatgtct tttttctcat cttttgccgc cgatgcctgt ttttgctgct 2432821 gatgagatgg ttcgcatgcc gataaactaa acagcaatac cgccagcaga ataaaacaaa 2432881 ctgatctcat cagcattccc ctccgatcat ctttattctc tcatatttgc ttcggcagaa 2432941 aaaagaaaaa gtttcagtta ctcatgaaaa aataacgccc tccacaagat accgcttgtg 2433001 gcgttatata tgtgtgaaaa ctgctgaaac ggcaaaggat tttggccttt tccaagttcc 2433061 accgtatacc cttccttaaa ataatggtga ataaaccaat cacgaaatcc agcatagctg 2433121 tctatatccc ttactccctt ataaatgttc ccgcttaact cctcaaactc ctttatgacg 2433181 gcagcagatt cctcaggctc aaggccttta tagccccaat aaatttcttc tccttgagta 2433241 tgaagagcca gcagtctgtc aggcggattc tccgtgatca gccggtacat cgcaatagat 2433301 tccggctccg taagcggaga gattcccgga aaatcgcggt agctgggtgc tgtcggtttt 2433361 cggtattttt caatttccca taatgatgga aattgtttat ttaaatcaac cccgtttata 2433421 ttcgccttcc attcattaaa atttggacga tgttcattta gcctttcgag ttcatctctt 2433481 ctggctccca tgacttctga tccgtttaaa acaagatcaa cgccatccgg attgacaaga 2433541 ggaacgaggg ataaggatgt gctgttaaac agctttatgg gagaaaagcc aaagaaaggc 2433601 gaattgcagc ataatgacat acagtattcc ttaaaccatt ttagcaggac agacgttgta 2433661 atccactcat tcgcatgaaa tgacgcgttc atatggacct tttttacggc atgctcccca 2433721 ccagccttca gctcccagat aggcctgccg agtacagaac ggccaatttc ccggcatgag 2433781 acaaacggaa aaacatcaat aatcttcttt atttcctttt caacagctga atcatcatag 2433841 attttctctt gctcaatcca gctatctgaa agtttcagct gccgaggctg taaaaagcgc 2433901 tttatgtcct gaatggtttg aagctctttg ccgctatgct cctctatcac ataaccaggg 2433961 caatacaatt gatgtttttg tgcggagcga tttgcacttt taagcaattc ctcgtctatc 2434021 ttcagttctt tcgccacatt ggccaaattg ttcttgatct caggtttcac cgtaataaac 2434081 gccatcatca tccccctttt ttgttactat atgacagcgt atttaaaaaa agaaagcctc 2434141 ccgctcactt cgatgcggga gacattgtga ttatgatgcc tgatcaagca tttgtttttc 2434201 tttccgcttt gacgaattgt ccagcctttt ctggtcataa aatcgcaaca aatccccata 2434261 aatgatttca tcagaaagtg atagctcctg ttttgcttta tcagcaaatg cttcacattg 2434321 ttttgtctct tctaacggtt ttcccgtctc tttgtcataa cacgcaccgt ctgtataaac 2434381 aacctgatct gtgataaagc tcccgtcccg gagcaccgtg aagtccagtt tttcgtctga 2434441 aagcagatcg ttgccgaatt gaatttgatc tttcgtatca atccctaaaa gattcatcag 2434501 cgtcggcctg atatcaatct gcccgcctac tgtttcaatg gtttgcggct ttttatcagt 2434561 aatacccgga atatgaatga ccagcggcac tttttggagc tgtacctctt caaatggggt 2434621 tatttctttt cctaaaaact gccccatcgc ttcattatgg ttttctgata taccataatg 2434681 gtcaccatat aatacaataa cagagttgtc gtataacccg tcttccttca gcttttcgat 2434741 aaaccgtttc agcgcctcat cctgataacg cactgtcgga aaatatttat ttagcgtctg 2434801 gctgtttgaa tcatattcat caatcaattg atcctcttca tcaagatcaa acgggaagtg 2434861 gttcgtcagt gtaatcagcc tcgagtaaaa cggctgaggc agatttttca tcagctctga 2434921 ggactgctca aaaaattctt tatccttaag tccccagccg actgaatttt cgtcagttac 2434981 atcatacgag ttaatatcaa aaaacgaatc atatccaaat gagtcgtaca ttaaatcacg 2435041 attccaaaag ctcttattat tagcgtggag caccgctgaa tagtatccgc tgtttttcaa 2435101 aatttcagga gcggccatat attgattgcc cgcattcgta aaaaatacgg cacctcgtcc 2435161 aagcggatac agtgaattgt ccacgataaa ttcagaatcc gaggttttcc cctggcctgt 2435221 ttggtggtaa acattattaa agttgtagct ctgttttata aagtcattca gaaaaggcgt 2435281 gatttcttct ccattcaatt tttcattaat cacgaagctt tgcgtcgact ctaaggatac 2435341 gagaatgacg ttccttcctt ttgcagcgcc gaataagcgt ttgttggcat ccttcgcatt 2435401 agcggttacg tagttttcaa tctccgtcag gctgttgctg tctgccaacg ctctctgtgc 2435461 ggattgcttt gactgaagaa cgccatcgta aatatgaaaa ttaaacaggc taatgttttt 2435521 aacaagcatt tctctgtcaa atgagcgtgt caatagctga ggtctttccg cctcagacaa 2435581 gcccaggttg aagaaataaa cagaagcaac gaacaaaaaa taagccgccc gttcattttt 2435641 cgttgaggga atgtccgatt gaaaagcttt ttgccggatg tgaagccata ttaaaaccgc 2435701 aatatctaca gctaatagga ggtctgtcgg ctcaagaagt gttccgatgc tgcttccgag 2435761 atcacccata ttgctcgttt gaaaaagaac agggattgtt aagaaatcat tgtaaaaacg 2435821 gtaaaaaacc atatttgcca gcaatacaaa cgtgacaaga cagctcatcg cgataatgta 2435881 gcgatttctg tttttgcctt ttaaaaacag gctgaggcca aaaataagca acaaaaaact 2435941 caatgggttg ataaacagaa taaattcctg tgttagattg tcgattttaa tatgaaaact 2436001 ggttttgtaa acagcatacg ttttcagcca catcaataaa atggcaatca gcataaatga 2436061 aatcttcgaa aaaaacgttt ttcgcatttc aacctcctat gcagcacgct caaaaaaatc 2436121 agtctattcc caacattctc attaacacat caaattaaat cttaacctga gcacaacaaa 2436181 aaatcaattt catttacaca attttaacaa ttttgatgtt tcagccattc atttttagcg 2436241 atccaagcgc ctccgataac gccggcatca tttccaagtg ctgcgattga aatatcagca 2436301 gcttgggctg cccgcggaaa cgcgcatttg cggaatgttt tctcgacttt tgatctcagc 2436361 agttctccgg ctctcgatac gccgccgcca agaacgattt tggatggatt aagcgagctt 2436421 gccaaatttc cgagcaccaa accaagatgc ttggctacat aatcaaccac ctcaagggca 2436481 atttcatcat tttcacccgc cgcttcaaac acatctcgcg ctgacaattg ttcggttgct 2436541 tttaaacgtg tcgtcttttt agcatttgct attttttctt ttgcaattct tacaattccg 2436601 gttgctgacg caattgtttc gatacagccc gttttgccgc agttgcaggg cgctccgcct 2436661 tcagggatgc tgcaaatatg gccgatttct ccgccggcgc catttatacc atgtacaatt 2436721 tcaccatttg caatgatgcc gccgccaact cctgtgccaa gcgtcacgag aatgacgtct 2436781 tttgcgccat cacccgctcc cttccacatt tccccgagcg cagcaatatt cgcgtcattt 2436841 tctataacag ctgggatgcc ggtttctgtc tccagatggt ttttcaaagc ataatttttc 2436901 caccctagat ttactgtttc ataaaccact cctgccgcca tatctacagg gcctggtgca 2436961 cccattccga tgtatttgat gatgtgcttc ggtttttgca gctcatccag cttgctgtcg 2437021 attgtttttg caattgtgac agtaatcgtg tcgccggttt tatctgtcgg aacttcccac 2437081 ttatgctgaa tttcgccata ttgattaata aaagcgagtt taatcgtcgt tcctcccagg 2437141 tcaatgcccg caaaccatat ctcgtccatt tttatcacct tagcctttat aaaaatctct 2437201 tccgtttttt gtttgttcca attcttttcg aaggacagct gccgctctgg cccactgctc 2437261 cttttcaatc atgtggttca tgtataattc ctttaattca tccagcataa actcaatttc 2437321 aagctctctg tctccaaaat aaacaatgtg gccaaacgtt tttaacagct gctgcacatc 2437381 ataaaatgta ttcattttcc tcaccatttc ttgaacttaa ctatcataag cgtattcata 2437441 aggaagcggt cagtcaagaa gaaaacgctg acaaaaaagc cagcttcctt tccatattcc 2437501 acctctatga ttctttattg ttttcaattt gccgctgcag ctccttgtag cgctgctcct 2437561 tcggcttcag tttcacagcc gtctggatgg ccttttctgc ttgtgcaagc tcattttttt 2437621 ccgcatacaa taacgctaaa ttgtaatagg aagcatggtc tttaggttct tttttcactg 2437681 ctcgttccaa aagggaaacc gcctgatcat attcgccgat ttgaatatca gaaacagcaa 2437741 gaattttcaa aagatcggca gaggcatctt tttgcgctgc ttctccgttc agcaattctg 2437801 ttacttcttc atactttcct tcctgataca gctcgcttgc ctgctgaatc agcgctgact 2437861 cctggtgtga aggcgaatgc aatccgtaat ataaaaatcc aacagccaaa gcaatcagca 2437921 aaaccgctga caacaatctt tttccaaagg ctccggcttt aggcaacccc agtgctgctg 2437981 cagcgaaaaa gccgccaatc aagccgccga tatgtcctga attatcaata ttcgaaaccg 2438041 caaaaccaaa gcccagattg atgataataa tgacaataat attggttcct atagttctta 2438101 aaaacatttt tcgattagac aaagcaacat acagtaatgc acctaagcat ccgaatatgg 2438161 ctcctgatgc ccctgccgaa ggatacgggc tgaacacaaa actcgcaatc gaacccgtaa 2438221 tgccagcagc cagataaatc agcaaaaatc tccccgatcc atacatccgc tcaaccgctg 2438281 taccaaccga ccataaagcc agcgtattaa aagctaaatg cgctatgccg atgtgaagca 2438341 cgatcggtgt cagaagccgc caccattctc cttgtgcaat caggctgttt tcttttgctc 2438401 caaaagccac cagtgtctcc gtattagtgc tgcctccgtt tatttcgagc aagaaaaaca 2438461 tcaggatctg aagcgcaata aataaatatg taaaagtcgg ttttccgttt tgaaaaaccg 2438521 ccgcttcagt ttttctctgt tcttcttgtt tcagcactag cgaaaggaag cgttctcgcg 2438581 ccatttgcgc gttttcaaac gaagcgtgtt cctctgaaca atcttctgta cgaaatgatg 2438641 gaaaaaccgc ttgaagatca tctcgaagca tcgttcctct aacgatcgcc ggctcaactg 2438701 acacagttcc cttctcaaaa gttttttttg caatctcttc ccagtcatca actggggctt 2438761 ccgttgaaaa aaacacgttc agcagcttca tccttcgtct gcccaattga tgtctgactc 2438821 gttctactcg ttcggcctgc tcttcgatgt ctctaaccat ttcttgacgg aaatcaagat 2438881 cgtgcttata aagacgaact agatcatgag aggacttgtc cggcgcttcc agccatattt 2438941 catctgactc accggcttgt atgacgccat acccgctatt caccaggtgc gccgcaattt 2439001 tccaatatgt atactccagc aaaaacatgt ttaccgctcc aatagttttt tttcattata 2439061 acagctggcg ctccgaaacg cctactgaaa gcaaaaaatc ccgtttttca cgggatttta 2439121 gaaagcttgc tgtataaact tattgcggat aaatggaatt cttaaaaaca aatggataaa 2439181 agaccgcctg attcctggct ggctgagtac agtattcata agacggtagc gattttgata 2439241 aaacatgacg gcagaaaccg cgaaaatggc atatatcaaa agttttttca tgatatccct 2439301 cctgccaata gggtttgtta ttctacctta tttattctcg aataagggac aggaaagtta 2439361 tgaaaaacaa gaaataatcc gatcctctgt tatcagctta tgtaccggga tgtcatgcgg 2439421 cagacggggt acgtgcgcaa acaactggca ctccaaaagc aaagagactg tcttcccttc 2439481 atattcactt aaatagcgat cataatagcc gcctccaaag ccgaccctaa acccgttaac 2439541 atcaaaacaa acacccggaa cgatcatcaa gtcaatttgt gatgggttta cttcttttgt 2439601 tttttcaatt accggctcga gcagtccggc gtacacggtt tcgagctgat catcagtctg 2439661 atatgtgcga aattgcattt tcttcgtgtc cggatggcat tttgggatgc aaacttgttt 2439721 cccttcttcc caagcctgct caatgacagg acgcgtcggt atctctaatc ctctggaaat 2439781 agtgacggca atggtgccgg cattttgcca ctccggcaga gaaaacaagt acttatacat 2439841 acgttccgtt ttttgaagaa tatcttcatt tgataaagca gacagtgcct ccagcgtctt 2439901 ttttcttaat tgtgatttca tctctcatcc ccctcggaat agaaaaaaag ccagaacctt 2439961 tttcaaagct ctggcttttt tcttacacct caaacagcaa agctgttatt ttgtttcacg 2440021 gtgtaacgta gattttttat cacgtgggca atatttttta aattcaacgc ggtctggatt 2440081 gttgcgtttg ttctttttag aaatatagtt acgctcacca cattcagtgc aagccaaagt 2440141 aatattaacg cgcattattt tccctccaaa ctaaaatcat ttacttattc agacttatat 2440201 ataataccac tataatggac ggaatgctag gctgtttttc aatgaattgc tgaattattg 2440261 aagatacgct cataaagctg caaatatgat gacataatga gtcgggggtg gtggagcttg 2440321 aacacttgtt gtctgccagc ttcttttatc cggcgggctt tttcccggtc ttttaaaaaa 2440381 ctgtccagca gatcagcagc ttcctgtacg agcgtaaaat cagcgatgat tgccgttttg 2440441 tcatgaaccg cataatcaca aaaaccacct gactgagaaa cgacagtcag cacaccttgt 2440501 tccatgcttt cttgcgcggc aagcccaaac ggttcataag aactagggaa aacagccatt 2440561 tcacagtgag acagtaacgt tctgatatct ttcctattta gaaacggcag aaacatgacg 2440621 cgatccttca ggttatatgc cgcagccaat ttctcatagc aggacagaga cggcccctcc 2440681 ccagccagca ctagatagag gtcaggctga cgctgcttca agatggcaaa cacctttaac 2440741 agctgcgata atcctttttc cggaacaaac cttccatatg aaaagaggaa tcttctattc 2440801 atgcttctcg ggattttccc cttctcttcc tccatagatg cagggcttgg gataacggtt 2440861 attttcttat gtgccgcctt atcaagagac cgcttcataa atgtgcttaa tacgatcaat 2440921 gcatcagcgg attctataag gagccgttcg gtcatgagcc tgtatgggtg tggggcttct 2440981 cggcacacct tcttcctttc gctttcaaga ccgtggattg tcgcagcaag cggaaggcca 2441041 agccgttgtt tcaaatactg ggcggcaggg gcagttgtgt catcatgggc atgaatcaga 2441101 tcaaagcgtt tattgtgtga taacacatgg cgaaccattg taaagttagc atcagctatg 2441161 taatcttcaa acttcgcata cgaaaacagc tgcccgctcg gagtaaaaac cgtaatgttg 2441221 atatgagggt ttaaatagga aatgaggcgg tttaaatgga caccgagccc gcttttcggc 2441281 tcatcgggat gttcgggtga aagcatgaga atgttcaccg ttctttttcc cctctcccat 2441341 aacaggtgta tgcagaaaat tgcgcctccc acctggtgtg cgcttcttca atctgaaaac 2441401 tgtttatatg acgaatccca ttttcatcaa gatagatgtc gtctgtaccg gcaagcttga 2441461 gagagacatt cattgaattc acaattctgt attcagcccg atatacagca tcaccagccg 2441521 cctgtctaat cgtccattct cctttatcat acgttgtgcg ttttgtcctg acagcttcaa 2441581 tgtcttttct tttgatgaca atgcgcaatt cttttatcat atcctgcgtt ttttcgaaaa 2441641 ggaccgcttc agccagccgc attgtttctt ctgagatttc ccagcttacg gtcaaggtgt 2441701 gagcgttttg aatgattatg tcgaatgtgt ccctaaaaaa ggaaagctta tgtcgtatat 2441761 tatagggaaa tgggtgttta tccatggact cctaacattc tcctttccaa tcgttcactt 2441821 cgtgttccta ttaaaccatt acatgaagaa gaagcgaaga aagatttctc gacaaaatct 2441881 cgtttttttc gcgaattcct ttagaaacta ttggttttat ggtataaaaa agaaggataa 2441941 aaaaagaata gaaggtgatg aaacgtggaa attgctatta ttgcgttgtt tatcgtcagt 2442001 atagcgctaa ttgcattctc atattctcaa agagacccga tgaaagatgt agaacaggag 2442061 ctcgaaacac tgcagctttc tgcgatgcag gaaatttaca agctcaaaaa gaaaatgaca 2442121 gtgcttgagg aagaattact ggaaacaaac cttgtcattc gcaaatcaaa gcagaacgac 2442181 atcaatcaaa aaatcgctaa acaaatactt tctaaatata ataacggtat gtcagctgaa 2442241 gcgattgcta aagctgaaca tgtatcagtg gaagacgtga atacgattat caaagataat 2442301 gagaaggtgc tcgtatgaca aaacggggca ttcaggcatt tgctggcggc atcattttag 2442361 cgacagccgt tcttgcagct gttttttatc tgactgacga agaccaggcc gctgctgtaa 2442421 aagataataa aacagtaacc gaacaagacg tgaacaatta tcttgattct aaaaaattgg 2442481 tttctgtcaa ccgtgatgaa tatcaaaaac ttctcgattc aaaagagaaa tccttaaaca 2442541 atgacagcgg ctcagacacg aaatcagaca aagtcaaaac ctacaagctc accattaaag 2442601 acggcatgag cacggcggat gtatctgcta ttcttgaaaa agagggcatt atctcttcgg 2442661 ctcaagactt taatgactat gtcattgatg ccggctatca caaagaaatt cgtgccggcg 2442721 agtttaaagt aaaatcagac atgagtttca aaaagatcgt aaaaacgtta acacgataaa 2442781 aaaacaggct gactcagcct gtttttttca tccaaacttt cctgaaatgt aatcgagcgt 2442841 tctttggtcc ttcgggttag agaacatttt attcgtattg tcgcattcaa caagctcgcc 2442901 catgtagaaa aaggcggttt gatcagaaac ccttgctgcc tgctgcatgt tatgcgtgac 2442961 aatgacaatt gtatatttat ctttcagctc tagaatgagt tcttcaattt ttctcgttga 2443021 gattggatct agtgcagatg tcggttcatc catcagcaaa atatcaggat tggtcgcaag 2443081 tgctctggcg atgcaaagac gctgctgctg gccccctgac agcgaaagag cggacgtatg 2443141 caatcgatcc ttcacctcat cccataacgc cacgtctttt aatgactttt ccacaatttc 2443201 ctgaagcttc ttcttatttt tggtgccgtg gactctcggt ccgtaagcca cattatcaaa 2443261 aatagattgc ggaaacggat tccctttttg gaataccatg ccgatatttt ttcgcaaatc 2443321 cacgatgtcc actttatcct ttaaaatgtt gctgccatta tagttcagct cacctgcaag 2443381 ctttacattc ggcgtcattt gaatcattaa attcaatgtc ttgataaagg tcgatttccc 2443441 gcatccggat ggtccgataa tcgccgtaac ctcattttca taaatgctca aattgatatt 2443501 ttttaaagca tgatgctgcc cataccataa gttcattcca ttgacttgat atacttcctg 2443561 tttcattaca gcttcggtag caatactcat tgccgccctc ctatccgaat ttcccgttaa 2443621 tataatcctc tgtcttttgc tttttcggac tcgtgaaaat ctgttcggtc tgtccgtatt 2443681 ctacaagctc gccgtttaaa aagaatgccg tccggtcaga aacccgcaga gcctgctgca 2443741 tattgtgcgt gacaataata attgagtatt ctcttttcaa tcctgtaatt aattcctcta 2443801 tttttgcatt tgaaatcgga tcaagcgctg aagctggttc atcaagcaga agaacagccg 2443861 gcttcatcgc aagcgttctc gcgatgcata aacgctgctg ctggccgccg gataacgaga 2443921 gtgcggatga atgtaaacga tccttcacct catcccagag cgctgctttt gttaaacttt 2443981 cttccacaat ttcatctaaa acagctttat tccgctctcc ggcatatttc aatgcatgtg 2444041 tgatattcgc atagatcgat ttcggaaatg gatttggttt ttggaaaacc attccgattt 2444101 ctcttctcaa gctgacaacg ttaatattgc cgcccaatat atttaatccc tcataaagga 2444161 tttcaccttc cgctcttgca gatggaatta aatcgttcat tcggttaata tttctcaaaa 2444221 aagtagattt tccgcatccc gacggcccaa ttaaagcagt caccgcattt ttttcaatat 2444281 ccatgtttac atgatgaacg gcttgtttat ttccgtaata aatggacaga tctttgacct 2444341 caagcacgtg gttctgcttc ggaacaataa cagctcgctc aggtttttct tttaccattt 2444401 gttcagacat gtttttcgcc tctttccgtt ctaatttgcc gtaagctttt tgtagatcat 2444461 cgtgccaagc catctcgccg cgagattaaa cacaagaaca gaaatcacca gcacggcaga 2444521 accaccgttg gcaatcgctt cagcatccgg aatcattcct tgtgtattga cgttccaaat 2444581 gtggaccgca agtgtttcag cgggcctgaa aatattaagc ggtgatgttt ccgaaaacgg 2444641 gttccactcc gtaaaattaa gacgcggtgt tgtcaggcct gccgtaaata ataatgcggc 2444701 cgcttccccg aacacccttc ctgacgctaa aattgctcct gtgatgatag aaggaatcgc 2444761 acttggaatt aaaactgttt ttacggtatg ccagcgtgat acacctaaag cgagagaggc 2444821 ttccttcaga tctttaggga ctgaacggat cgcgtcttct gtcacacgca ccatgacagg 2444881 aaggttaaaa acagttaacg caagcgctcc gcctatgatc gtataacccc agcctgttaa 2444941 gttgacaaac atcaataatc caaacatccc aatgacaata gacggaagag atgaaagcac 2445001 ctctatacat gttctaatga agtcagttac tttgttatta ggcgcgtatt cagccatgaa 2445061 gactccgccg cccacaccga gcgggattgt aatcagcatt gtaataaaca aaatataaaa 2445121 ggagttaaac agctgatctc gtatgcctcc tccagctgca atggcgctcg actttgttgt 2445181 aataaattga aaactgagct gagaaacacc gtttataata atataggaaa acaaacctac 2445241 taaaatggca gcgataatgg ctgcacacaa accaaacatt ccggtcgcca gtttatctgt 2445301 tattttgcgg ttcattacac tttcctccta gatgacaagt agcgaataag caggatgaac 2445361 aagaatgaca tcaccagaag cacaagcccc attgaccaca gcgtattgtt ttcaacactt 2445421 ccgtatgtgg tgtggcccat attcagcgtg atgatcgttg tcagcgttcc cgcagtgtca 2445481 aacgggcttt ccggcaatac tcttgtattt ccaatgacca tctgaacagc caaagcttca 2445541 ccgaacgccc gagccatgcc taacacaaca gctgtcatca atgttggaaa agctgcaggc 2445601 acaagtactt ttctgatcgt ctgccatctt gtggcaccaa gcgcgtaaga accctctcgt 2445661 aaactcttcg gaagagaagc cattgcatca gcagaaatcg atgtgatcgt cggcagaatc 2445721 atgacggaaa ggacaatcgt tcccgccaat aaactgtgcc ctgttccgct cgatttgaac 2445781 tgggcgataa acggcaccaa tactgtaaga cctatgaatc cataaacaac agatggaata 2445841 ccgactaaaa gctcaatcac cggctgcagc actttctttc cccaattcgg ggcaatctct 2445901 gtcataaaaa tcgcacctgc aatgccaagc ggcgcagcga ttagagcaga aagaatcgtt 2445961 actgcaaatg agccaaaaat aaatggcagc actccgtatt tcggatcact atctgtagga 2446021 ttccaattta agctcgttaa gaattcaatt gggcttacac catttacaag aaaagattgc 2446081 agccccttaa cgccgaggaa aatggtaatc gcaacagatg ccgcaatcat aatcagtgca 2446141 caagctgtga ctatcattct tccccgaact tcatccaatt gccgattttg cctagagctg 2446201 attaagcgct cgctcacaga catattttct ctattgttta tcattgtttt acactcctat 2446261 gaatgtgtta agaggagaaa cggttgtccc cgcactcctc tttttattaa gatcagcttt 2446321 gcttcccgtt ggcatcacgt gtcactttca tatcagtaac cggaatgtag ccttggtcag 2446381 taacaatgct tttttgaatg tcttcactct ttagataatc aagaaattct ttagctaaac 2446441 ctgtcgcttc accttttgta taagaatgtt gataagccca gatcggatac tcgccagttg 2446501 ctacattttt cgcttcaggt ttaacaccgt caatagatag agcagttact ttgtcatctg 2446561 ttaaatatga gaatgcaaga tatccaatcg ctcccggagt atcagcaatg atctttttca 2446621 ccgtgttgga ggaatcttca gtaatgcctt ctgcaggctc cgctccgtca agcgcatatt 2446681 tcacaaatgt agcacgtgtg ccggaagaat cagggcggtt tacaagtgta atcttttggt 2446741 ctttgccgcc gagctctttc cagtttttga ttttgccagt gaagattttt ttcaattcat 2446801 cttttgaaat atcctttaca ccagcatcag ggtttacagc tgctgccata ccaactacag 2446861 cgacttgatg atcgacaagc gcttttgcat cgatgccttc tttttcttca gcaaaaacgt 2446921 ctgaattccc gatctgaaca gctccttcag agacttgaga aagccctgtt ccagaaccgc 2446981 cagcttgtac ctgtatatca gcatcagggt tttcttccat aaatttttcc gcggctgcaa 2447041 gtactagtgg ctgcattgcc gatgaaccag aaatggttaa agaacctgat gccttttctt 2447101 ctccttttgc agaatcgcta ttcgattttt tactttctcc tgcatttccg catgcagctg 2447161 caatcatcat aaaagcagcc atcagaagca taagcaccaa tttgtttttt ttcatttcct 2447221 gaattccccc tgcgtataat gtgtaatttg tcctacacgt atagagtaaa ggttctatgt 2447281 aaaaagggtt tgaaccgaat gttaaggttt tgtaaatcag tgcgtttttt gtataaaaaa 2447341 aacgcccaca tcatgtgagc gttttttttt agttatcaga agacgttgtg ttttctgcat 2447401 tttcttcaat tttgtcttta ttcttttgct gagtaccttc tttgtcctgc ttcgatttca 2447461 gctcaaaata tttatccatt acttccctgc cgatttcgtt tgtaattgag tatctttgat 2447521 tgtaatcaat gtaagtccaa ggaactacga cagaaatagc aatctcagga ttgtcagctg 2447581 gtgcataagc cacaagcgtc gtattataag tgtctgttcc tgtttttgat ttatccggtc 2447641 cgtcgtaaaa tgattgggct gttcctgttt ttgcagctgg tttatacgat gctgaagcca 2447701 gttgacctgc agctgtccct ttagtggcaa cccgtctaaa accggcttgg acctcttcaa 2447761 tatagctact cttcatatcg actttattca atacttcagg ctgaacagaa tcaacgactg 2447821 cgccgatccc ttttttcgca tttgaatctc tgacttcctt tacaagctga ggcttcatgc 2447881 ggtagccacc atttgctatg gtggagacat attgagccaa ttccagcggt gtataagtat 2447941 catactgtcc aatggcgaaa tcaagcaaga aaccagataa tctgcttgta cctttatatc 2448001 ccgtcatttc atttggtaga tcaattcctg tttttactcc taatccaaat tgactgaaat 2448061 aatttctgaa ggtatcaaat gcagaagtat ccaaaggcaa tgcttggtga ggtttatatt 2448121 cacctttacc aactgcaatt gctgttttaa acataaaaac gtttgatgac ttctctaatg 2448181 cagtttgaat accaaccggc cctaagtttt gccaagattt tttccctctt ttatcctggc 2448241 cgatatacaa tggttcatcc ttaaatacag tattcaaatt aatcgctcca gtttgaagac 2448301 cggtcaaaac ggttgcacct tttacagctg atcccatagc gtaggatgaa gtcatggctc 2448361 ctaatgcata atcatcaaac ttataggctc cattttctcg tttaatctgc ttccctgcca 2448421 ttgtcagcac ttcgccgttt ctagggtcca tcatgacaac gaatgcacga tccaacaatt 2448481 cggtactagg tcttgcttta gcagctttaa gttttttctc aataattttt tccactgatt 2448541 tttgcaaatc aatatcaatt gttagtacaa gatctttccc ggctttgcct tcagataccg 2448601 tttttgttcc cgtgacattg ccttttgaat ctgtgatatt ttcgactttt gctttttggc 2448661 cctgcagaag gctttcatat tggtattcca gatagctttt tccgaccctg tcatttcggc 2448721 tgtagccaag cgacagataa tggtcgagca agttggacgg caatccttca ttagagctgg 2448781 aaacacttcc gagcactgag cgaagaaggt ttttataagg atattcacgt tcccaatcgg 2448841 acgtgacatc aacacctggc agttcgtcta aatgttcact taccactgcc atttccttcg 2448901 ctgatacatc ttcgtttttg atatattgag gggtcaatgc atagcccgaa tccatctgtc 2448961 ttttgatagc aaggatctgc atatctttat ccgtcaattc attcagctgc ttatcagtaa 2449021 tccgttttag ctgaagctgg tataaatcgt catcggatat ttttttgtct tcaacctgct 2449081 gtctttcttt agagctaatg agctttttcg cttctttcgg tctagtcaaa atccaataat 2449141 cttttttatc ccgttctgtt actttttttg tatcgacttt gatcatgtca gacagctttt 2449201 ttgcgatctt taagcgctgt tcttgcgtgg tcgatttaga tctcgtgtat gtgattgcat 2449261 ttaaagcctt atttgtcaca atggcattaa agtttcgatc ataaattttc ccgcgtggta 2449321 ccgctgagct gacttcactt tgttcctgct tattcgcttg gtttttgtaa tcatcacctt 2449381 gcacgatctg cttgatgccc agttccacaa taatccaggt aaatataaca aaggcagcta 2449441 aaaataaaat attcagccgg atcggaagcg acttcttttt ctctttatga ttttgctttt 2449501 ttggtttatt tctcctcata acatcacctt ttctatttac agaaagaaaa gacactcaag 2449561 taagagtgcc agttttcatt ttaaaggttt tttcgacttt tttctacaga taaccccttt 2449621 ttggcaaaaa aattatctct cgccttttaa aagggtcggt tctgttaccc gtttttggcc 2449681 gtcttcttcc atggtttcat tttccccttc tttctcctta aaacgaatat ccttgacaaa 2449741 gtaataaatc aaaggatgtc ctatacccaa tatcgcaagt gacaaaggaa ttcccacatc 2449801 ctctttcaga agggccacaa tcaggagaaa gcacaaaatg gaaacaattc tgccggcgtt 2449861 caagaacatt tctctaagca cgatatattc aattcttgct tttctggcat gcctcgcgcg 2449921 ccctatcaca tcatatgtaa gtgatacata tggcacaagc aacagaggat agccgatggc 2449981 aataaaaacg ccgtacgtta ataatgtcga aaagctcata tggaacagaa tcaaaaacag 2450041 cgcgccatac aaaataagtc cgcccagcaa aatcgatttt tttctcgcct ttttcttaat 2450101 cagcctggat gcaaagtagt aggcaaagaa ggaaacagct gaattgacaa gaccgaatgt 2450161 accgagagca agctcgctgt ttgtctcaat aaatacaaac acactgatta aaaagacaaa 2450221 aatcccttct ctcaaaccct gaaaaaaatg cgcattcgtg attctccgcc aattcatatt 2450281 gctatggcgc tctccaaata ctttgctcag cataaaacgg ccctttgatt ctctccgttt 2450341 taagaaaaag ctcatcacga cagccagggc aaataaactg agggagagac tgaaaatcac 2450401 tgtataaccc gtattatttt caagccttga gatcacgaat ccggctacaa tcgggccgat 2450461 cattcctgca gaggaagaca gaatgcccat aaacccgttg aaaaagtctc gtgtatccgg 2450521 ctctgttatt tcaaaggtca gcacgttaaa cgctagccaa taaaagccat agccaactcc 2450581 gagcaccgcg ccgattagca cgaggcggct ggccgccgtt tctccggcta aaagcacact 2450641 taaataaaag gcagctaaaa aaatgacgcc gaaccttaaa atgaataccc tgtctatttt 2450701 tttggctaac cgtccagcca aataaaaggt tatcggctgc attgtcacaa tggataaatt 2450761 atatatcgcc aaatcaataa atttccctga ctgcttccaa agatacacat taacaaatgt 2450821 attggacagt gcaattccca gcgagtaaag cccgccaatg gtcagcagaa agagtaagcc 2450881 tttgtttacg tctacatcgc ctatcacttt ttttagtttg ctcattactg actccccttt 2450941 actatccctt agtctgtctc actcaaaccg agatatgtaa aaagaagaca taaaaaaaca 2451001 aggtcccata atgaggacct tgtttgtgcc attattttgc ttcgctgtat agacgagcca 2451061 cttcgtccca gtttacaaca ttccagaaag ctgaaatgta atcaggacgg cggttttgat 2451121 agttaaggta gtaagcatgc tcccaaacgt caagacctaa gataggcgtt ttgccttctg 2451181 aaagcggaga atcttggttt ggcgtgcttg tgatttcaag tttaccgttg ttcacaacaa 2451241 gccatgccca gccagaaccg aagcgtccag ctgctgctgc tgcgaattgc tctttgaatt 2451301 tgtcaaagct tccaaataca ctgttaatct cttcagcaag cgcgccagtc ggttcgcctc 2451361 cgccgtttgg agataaaagt gtccagaata atttgtggtt cgcgtgtccg ccgccgttgt 2451421 tgcggactgc agtgcggatg ttttcaggaa cagaatcaag atctgcaaca agctcttcaa 2451481 ctgatttgtt ggcaagagca gtgtttcctt caaccgcttt gtttaaattt gtcacgtatg 2451541 tgttgtggtg tttcgtatgg tgaatagtca tagtttcctt gtcgatatgc ggttctaaag 2451601 catcgtacgc ataaggtaat tctggaagtt cgtaagccat gataattcct ccttagtata 2451661 tatgtactga aatgccgctt cacagcgagc ctttcttcat tcaatgtaac aaaagaatgc 2451721 tttgtaatca atgaaaaagc tcacgatttg gctcatttca gcggacatat ttcactttaa 2451781 ccgataatct gccccattaa acctgccgcc agcatttctt ataggaccgt ccataaaaag 2451841 taaccgatca tcaaaagctg tatgatgccc tttgcaataa cccctgttaa aaaaccaatg 2451901 agtgagccga ggccaatttt aaacgctgac tttaagtcct tctgatggac gataagttct 2451961 gcgcaaacag ccccgataaa cggccccaat atgatccctg caaccggaat gacaaaaggc 2452021 ccgattaata aaccgatcgt gcttccccat atggcagctt tgcttcctcc gaaccttttt 2452081 actccaagca gattcgacac gtaatctgct gcgaataata ctgcggcaaa aactgcctca 2452141 acaagccaga acatataaga atacggactg aatgaaaata aaaatccgta caatacaaat 2452201 ccggcaacaa taaatactac gctaggaata acaggataca ccagcccgat aaaggcaatg 2452261 ataaaaaccg ctgcaatcaa cagccaatac aacatatcca tagcttccat cctcccattt 2452321 tactctgtct tcttcatgtc ttccttgtat tcacacgcat gcaacgatac aataagcaac 2452381 atatattagt ttagctagga agtgaagata gtgaatgtgt ttcagctttt cattaaaagt 2452441 acatactctc cccgtgatat tgcaaaaaca agatttcaag gaatcggaaa agcgattctt 2452501 tatgtatttt tgctctctgt cctgtttgca atccctaccg cttattatgt aagtacaggg 2452561 accgtaaaat caatgaacgg ctttaaaact gttttaaaca aagatttccc tgatttcaca 2452621 atttcaaacg gcaaacttca aacggatgag aaaaaagcca cggaatctca ggcaaatggt 2452681 ttcgttatcg tgttcgatcc gacagactcc tatggcactg aacaaattga agcaaagcaa 2452741 aacgcaatcg gcatccttca gaacaaattt gttttggcca ttgacggaca agcccaagaa 2452801 atgtcttact caatgatgcc gtcagagtta cagaaaaaag atgtcattgc aggtttaaac 2452861 caaaataaag cgatgattgt aactgttctc tcagctctta tttttctcgt aacagcagcg 2452921 ggaaaattta ttgaagtatc gtttttagcg cttatcgggt taatcattaa gaattcgcag 2452981 aaaaaacatt tatcctatca tcagctctgg aagctttctg cttattccat cacactttca 2453041 actgtattct ttacaatcat gcgggcacta gaagcaaccg taccaagtga atttttgctg 2453101 aactggtttg tcaattttgt catcctgttt ctcgttttaa aagagattcc gtccaaaaaa 2453161 gtaattaata aaagttaaat tatatttatt tttatccttt aagtagagag tgtgaaagca 2453221 tttgcattaa ctttttactt aagggatatt taataaaatg tatagagctt aaacagatac 2453281 atttataaaa aaagctctac aattactcaa gaacaagctc tggacaataa tatcagaagt 2453341 agtaagatgt aacatgaaag aagttcttaa cagcatttga catatgtttt taacaaaata 2453401 agaataatgt taaattttaa ctaatagact agttaaaatc atatggcaaa atattttgca 2453461 tcctttcaca acatatttac ataagatagt tgctatttaa aaagccaggt accaataggg 2453521 cacctagctt tcagaattaa atcatcaaca agttagaatt atcttctttc cttctattct 2453581 cattattgaa ctgttatctt ttttgtgggt ttatgtatac aaatgcagct cccttagctt 2453641 tccccttata tactgataaa cctactgccc aaggtgttcc tgtcggtttt ggtaatttac 2453701 tgaagtaaaa ctttttggtt ggagttctac ttgaaaagta ccctgaatat tgcgggccaa 2453761 tgtccccacc ctcaactata gatacaccaa agctcttata atttagttta ccgcattttc 2453821 catttgtttc ggcgtaagca tcaatagatg ttgcactctt agtatatgta taagcatctg 2453881 taataactct tattttacaa ccagaaatac cacttaccgg ttgccaacca ctgcttgcag 2453941 cctctgcttt ttctttaggt gcaactacca aagttaacat tagtagcaaa attaaaaaca 2454001 cagaaaattt tccttgcttc attttgtaga tcctccttta aactattaca taattatcct 2454061 aacagatcca ttgttcattg taaataatgg aatacgagtt ttatattata aaagcctctt 2454121 tttgatctaa ttttgcacta ttttctattt tctatctgaa gttaatgttt agtcgaagaa 2454181 atcctgtcaa aaaagcgcct gtataaaaac cgagcattcg cagtctcttt tcttttgtca 2454241 tgaatcgaaa tggacaagca tactatggta taaaatttcg tatgcgggag gaaaagcgat 2454301 gaagcgtctc accttagtat gcagcattgt ttttatactt tttattcttt tttatgacct 2454361 taaaattgga accataccca ttcaggacct ccctgtctat gaagcatcag caaaaacggc 2454421 tgtacaagaa ccggcttata aaacggtgaa ggtaaagccg ggtgatacgg ttatgtcgat 2454481 agtcggatca gcaggttctc cggatgacat tgtaaaggat tttgaagcac tgaatccaaa 2454541 tgtgaaagct aacgccattc aagccggaac agcgtataaa ttcccggtct acccttaatt 2454601 taacgttaat ttcttgtcag ttcggcgaag acactgttac aatgtaattt gtaaaataaa 2454661 ttcacataaa ccatactaga attgttatat ctagaagcgg caactacaat taaggagcga 2454721 ttgcaagtga gtgaaatcac acatcgtaca aaaacgcgtc ccgtcaaagt gggaccttta 2454781 acaataggcg gcaacaatga agttgtcatc caaagcatga caacaacaaa aacacatgat 2454841 gtagaagcaa cggttgcgga aattaaccgt ttggctgaag ccggatgcca aatcgttcgg 2454901 gtagcatgtc cggatgaacg ggcggcaaac gccattgcgg atattaaaaa gcgcatttcc 2454961 attcctctcg ttgttgacat acatttcgat tataaacttg cgttgaaagc cattgaaggc 2455021 ggcgcagata aaatccgaat caaccccggc aatatcggcc ggcgcgaaaa agttgaagcg 2455081 gttgttaaag cggccaaaga caaaggcatt ccgatcagaa tcggagtaaa cgccggttca 2455141 ttggaaaaac ggattttaga aaaatacggt tatccgactg ccgatggaat ggtagaaagc 2455201 gcacttcatc acattaaaat tcttgaggat cttgattttc acgatattat tgtcagcatg 2455261 aaggcctctg acgtgaacct tgcaatcgag gcttatgaaa aagcagcgaa agcgtttgac 2455321 tacccgcttc acctcgggat caccgagtca ggaacactgt ttgccggcac agtaaagagc 2455381 gcagcaggac tcggcgccat tttaagcaaa ggcatcggga acaccatgcg catttcacta 2455441 agcgcagacc ctgtagaaga ggtaaaagta gcaagggagc ttctgaaatc tttcggctta 2455501 gcctccaatg ctgccacgct catctcatgc ccgacttgcg gccgtattga gattgatcta 2455561 atcagcattg ccaatgaagt ggaagagtat atttctaaga taaaagcgcc gattaaagtt 2455621 gctgttctcg gctgcgctgt aaacggacct ggtgaagcga gagaagctga tatcggaatc 2455681 gccggcgcac gcggtgaagg gctgctgttc cggaaaggga aaattgtccg taaggttcca 2455741 gaggaaacga tggtagaaga actcaaaaaa gaaattgaca ttcttgctga ggaacactac 2455801 gcaaaacttg aagctgaaaa agcaaaatta aaagaagaaa cacaaaaagc ttgacgggaa 2455861 cccgtcaagc ttttttgtgt tagaaaaatg gaataataaa tattccaagc actaatgaaa 2455921 cgacaccgat acccattgcc caggctccaa ggccttgagc acctcttctt cttgcgatat 2455981 agccgacaat aataccagca gctcccaata aaacaggcag tacaaacaat gaaatgatgg 2456041 acaaggctaa agcgatgtac cctattcccc gtccttcatt gacattgccg ccgctgcgat 2456101 cattgtcttg gtcattgctg cggtcagcag cacgataagg ctctgcgatt tcagcagctg 2456161 tttcctcaaa aaaaccgtca ttgtcgcggg taatatttgt cccttcagat ccatgatcaa 2456221 catagtaact gttgttatca cgcttttcgt aatcgtttgc caccttcaat tcccccttct 2456281 gttttattaa aggagctttt atagtttgat ccattttgcc tgattcatgt ttgctaaact 2456341 tttctgttaa tgtcaattgt ttatgttaca cttgaaggga tgaaactgaa ggagtgtggg 2456401 catgttacgc ttaggaatag atattgacgg cacaatcacg gctcaggata cattcgtccc 2456461 ttatttgaac cgttcgttta atctttccat ttcattaaac gatatgacgg attatgattt 2456521 aacaaagctg ttaaacatta cccaggaaga attttgggat tggatgaatc aaaatgaagc 2456581 gatcatatat aaggaagcat tgcttgcaca gcatgcgaaa cagtctctcg atcttctcaa 2456641 agaggagcac aagcttattt atattacagc gagacggact catttaactg atattactta 2456701 tgaatggttt gacagacaaa acattcatta tgaccacatc gaacttgttg ggggtcatca 2456761 caaagttgaa gcggtcaaga atcataacat cgacctgttt tttgaggatc atcacgggaa 2456821 cgccatgatg attgcgaaag aagccgggat accggtgatt ttgttcaatt ccccttataa 2456881 tcagcttccg attgattcaa acatcatcag agtaaacaac tggctagaag ccgttcaatg 2456941 gatgaacaac aacaagcatc acttaatacg cgtcaataac tgaaaaagga gcccaaaccg 2457001 ggcccctttt tcatatatac gcattttacg cagtagtgtt ttcttggttt tccgctgtac 2457061 aatcagggca tgtgccataa atctcaaatt tatgcccgct gacctgatag ccatccaaat 2457121 catcacaaag cttgtccatc ggacatgatt caatttcctt tgttttgccg caggcaagac 2457181 aaataaaatg atggtggtga tgggtgaatg aacacttaaa tcggaagagc ttttcaccgg 2457241 acagctcagt tgtttccaaa atcccaagtt cttcatataa agaaagattt ctgtagattg 2457301 tatcaaagct taagcctgga taatcatcat tcagtgcaga cagtacgttt ttagcggtaa 2457361 gatatctgtc tgaatcagca aaaagctgca gcatatcctc ccgtttgttt gtatatttat 2457421 atccgttttc ttttaatagg ttcagcgctt cttggacgtt catgaagggt cccccttttc 2457481 gctttgctta agaacgtatc acatgtatga aaaagaaaat ggcagctgtc tgtccagcaa 2457541 gccattttct ttactgcaga taaaattata cccataaaat gaataaaagt aaatgaaagc 2457601 ctagtggatt gcgtttttga attttccgcc tctcgtttca tgagtattca taattgttat 2457661 gaatgcattt tgatcaactt caaacacgat cgatttgagc tttgtcactt ccagccttgt 2457721 gacaaccgcg taaattacgt ctttttcttc gtccgtatac ccgcctttcc ccttcagctt 2457781 cgttgtgccc cgaccgagac ggtgcaaaat cgcgtcggaa atctcatcat actgctcaga 2457841 cacaataatg acagcttttg tttcatcaag cccttggatc acggcatcaa tcgttttcat 2457901 cgcaatataa taagtcatga atgagtacat cgcttgctca ggaccgaaca caaaaactgc 2457961 ccaaatgaaa atgaacacat tgatgaacat aacgaactca cctacagaaa acgggagttt 2458021 tttggtcagc aaaataccga gaatttctgt accatccatt gaacctccat ttcgaataac 2458081 aagcccgacg ccaaagccga gtaaaagacc tccgaacaca gtagccaaaa taggctgggt 2458141 tgtaatggct tctacatggt gaagtgagga ttcaataacg gcaagcccga caatccctat 2458201 aaacgtagag actagaaagg tcttaccgat atatttatat ccgaagatca taaaaggaat 2458261 atttaatatg acaacgaaaa aagcgaaatt cagaaagggg tttgacataa agaggtggtc 2458321 taaaataaga gatacaccga taatcccgcc atcaataaaa tcattgggga ttaaaaataa 2458381 ttcaatactt acagccgcag atgcagctcc taccagaatc ataaagaccc tgaaaataaa 2458441 atgggtaaat gtttctttct tatgttgttt tgttggggtc ataaaatctc ctttcctgca 2458501 ataactattt taaatacatt ataaatctat tttaccatta aacactgaca cattttactg 2458561 atttgcccat acattaagtc tggaggtgga atgaccgatg attttatttc aaagaattat 2458621 tttgcagcgg cttaatcagg ctactgctga tgatttgctg aagtactcaa aacaatacgg 2458681 aatcagctta acaagatcgc aggccgttga agtagcgaac ctgttatacg ggaaaaatgt 2458741 aaacatcttt aatgagagtg aacgaatgcg gctgctgaaa caagtagaga cgattacatc 2458801 gaaagaaaca gctcaaacag ttaatgaact attcaaacaa tttacaagct aaaaaatggg 2458861 ggtgttatcc cccatttttt attgctgtaa aatcttttca agcaatgtat catcaaattg 2458921 tttttctttc agcatttcaa tctcaaaacg gtatggcggt tttttgttct ttttatcttc 2458981 accgacgtat ggtgtttcaa gaatttttgg aatgtctttt aactgctcat ggtgaacaac 2459041 atattgcagt gcgtcaaaac ctatttcacc aaagccaata ttttcatggc ggtcttttct 2459101 cgcacctttg acatttttgc tgtcattgat atgaagcact ttaatacggt caatgccaat 2459161 gattttatcg aactcattta gcactccgtc aaagtcttcg acaatgttat acccggcatc 2459221 atgtgtatgg cacgtgtcaa agcacactga cagctgctca ttgtgtgtaa cgccttcgat 2459281 aatctgcgca agctcctcaa agcttctgcc gcattctgat ccttttccag ccattgtttc 2459341 taatgcaatc tggacatttt gattcggatc aatcacttca tttaagcctt caataatttt 2459401 tttgatgccg gcttcagctc ctgcccctac gtgagcgcca ggatgaagga caatttgctt 2459461 cgctccgatg gccgctgtcc gttcaatttc tgaacgaaga aaatcaacac ccagctcaaa 2459521 agtggacgga tttgtcgtgt tgccaatatt aataatataa ggcgcgtgta cgataatctc 2459581 gtcaatgccg ttttcttgca tatgtgcccg gcctgcttct atatttaagt cttcaatttt 2459641 ctttcggcgc gtattttgcg gtgcgcctgt atagatcata aacgtattcg ccccataaga 2459701 gactgcttcc tggcttgcag ccagaagcat atgttttccg ctcatagaga cgtgtgagcc 2459761 tattctcagc aacaggttcc cctactttct tttcttagat tggtttcttc tctgtttttt 2459821 cttgattttc tccatctcat agctcatttt ctttttatac ccaggcttaa ccttcttcgg 2459881 ctttttcacg agacgatgag caatttcatc cgcttcattc ggcgtttttt tacgtttttt 2459941 gcggcgctga cggtcatcgc cttttttcca ttcgcccttt tcaagctcta agtactcaaa 2460001 ttcgatgccc attttttcaa gtcttactaa tgcatcctca tcagtaagct cataaatggt 2460061 catcgcttgt cctgatgagc cggcacgagc cgttctgccc acacggtgaa catagaaatc 2460121 gagatcatcc ggcagctcat agttgataac atggctgaca cctttaatat caatacctct 2460181 tgcggcaagg tcagttgcaa tgatatatgt gaattccaaa tcattgatct gcttcatgac 2460241 ttttttccgc tcacgtggtg ttaatccgcc gtgcagcaag ccgattttca tgcctttgcc 2460301 agtcagatac tgggcaatat ggtcagccgt atttttcgtg ttggcaaaca caatccccag 2460361 gtatggattc agatgcgaca tgatgtcaaa aaggagcttg tccttgtcac gatgtttcga 2460421 aggaatgagg atatgctcga ttttcgcagc agtcacctgt tttggctcca catgggcgta 2460481 tttcggattt tccatgtatt tcttcaagaa tggtttcagc ttttccggta tggtcgctga 2460541 gaacacaagc atttgcagat cctcaggcat gcgggaaccg atgtaatcta catctgcaag 2460601 gaatcccatg tccagcatta aatccgcttc atcaataaca agagattccg ctttatgaac 2460661 acttaacgcc tgttctttga ttaagtcagc aatccgtcca ggtgtaccga caacaagatg 2460721 cggctgtatt ttcaatttat caattgattt ttgtttatca gtgcctccga taaaacattt 2460781 cgagcgaatc tgacttcctt cttcaccctg cgtgatttta agcgcttcct gataaatctg 2460841 gttggcaagc tctcttgtcg gagccgtaat gactacctga acgacatcct tagcaggatc 2460901 gattttgttt aataaaggca gtaaataagc gtgagtcttt ccagtacccg tctgagactg 2460961 gccgatgacg ctttcttttt ttaacactgc aggaatcagc cttttctgga tatcagtcgg 2461021 ttcgtaaaaa ccaaggcgat gtactgcatc tataataaat ggtttcaatt cataaagttc 2461081 aaatttcgtt tctttcattt ttcccagctc cttaaagcgg cacattatgt gtccatcatc 2461141 acattatacc cgattttgct taaaaacacc acgtttgcaa ggcgtttgtt ttattcagtt 2461201 atgtaaagca aataccgcag cccatgcata ttctaatagc agagagagct gaaaggaggt 2461261 acaagtatgt tttcaccgca gcagccaatg agaaattacc cacagcccgg accgccccgc 2461321 cccatgccaa atcagcgaat gatgggcaga agaccgccta atatgcgagg accttcattt 2461381 ggagcacagc agcaaggttt tcagcaagcc ggacaatttc ttcctcaggc aaatgccgga 2461441 gcgagaaatg gtgcaggtgc aggcggaggc ttaaaaggaa tgctgtcaag gttcctcccc 2461501 ggcggaggag gcgctggcag cgccggggtt cccggaattc caggagcagg tgcagcagcg 2461561 agcggaggtg ctggcctgca aggcattcaa aatattgcca atcctgcatc attatccagt 2461621 atgcttggaa atgtgcaaaa agtactcggc atggcgcagc aagtcacccc tatgatccag 2461681 cagtacggcc cattagtccg caatctgcca gcaatgatga agctgtacag ccaattaagt 2461741 aaaagtgatg atactgagac agaggccaat gaggaaagtg aaaaacaatc cgtttcagaa 2461801 gaatcatcag aaaaagaaaa agagactgaa acaaaaacct cagatgggaa caaaaaatca 2461861 aaaccaaaaa gttcttctct cccaaagaaa tctaaaacaa ctgacaataa agaacaagaa 2461921 ttaaaaacat ctgccccgaa gaaaaaggaa gctgcctctc ctgctccgaa aagaacatca 2461981 ggcagttcaa aaccgagatt atatatttaa cattctttga tatcttaagt gagattggct 2462041 ataatgagat cagaagaatg caagaataga gccgtttgat tacggctttt tatattgcct 2462101 ttactcactt cagtattgga ggacaaccga aaatggacgt aattaaaatt tcaccgcgcg 2462161 gctattgcta tggtgttgtt gatgctatgg tcattgccaa aaatgcgtcg ctagataaaa 2462221 gcttgccaag acccatctat atactcggga tgattgttca taataaacac gtcactgatg 2462281 cgtttgaaga ggaagggatt tttacattgg acggctctaa ccgtctggac atcttaaagc 2462341 aggttgacaa aggaactgtc attttcactg cgcacggtgt ttctcccgaa gtcagaagaa 2462401 tcgcagaaga aaaagggtta gtcgcaattg atgctacatg tccggatgtg acaaaaactc 2462461 ataatctaat cttagagatg aaagaaaaag gatatcacgt gatctatatc ggcaaaaaag 2462521 ggcatccaga gcctgaggga gccgttggcg tagcgccgga gatcgttcac ttagttgaaa 2462581 cagaagaaga tgtaaagaac cttgatatcc aatctgagaa gttaatcgtg acgaatcaaa 2462641 caacaatgtc tcaatgggat gttcacgaca ttatggagct tgtcaaagaa aaatatcctc 2462701 atgtcgaata tcaccaagag atttgcctcg ctactcaagt gcggcaggaa gctgtatcag 2462761 agcaggcaaa aaaagcggac ttaacaatcg ttgtcggaga cccgaaaagc aacaattcaa 2462821 ataggcttgc tcaagtgtca gaggaaatag ccgggacaaa agcataccgg atcggcgact 2462881 taagcgaatt gaagctcgaa tggctgaaag gcgttaatac cgttgcagtt acagcgggag 2462941 cttcaacacc gacgccgatc acaaaagaag tcattcgctt tttagagcag tttgatcacg 2463001 aagatccatc aacttggaca actgaacata atataccgct caaaaaaata cttccaaaag 2463061 taaaagcaaa aaactgaggc tgtaaaagcc tcagtttttt tatagaaatg taaatggatt 2463121 tgtatctgtt tcagaaacaa agatattcac gccaaacttt ttatcattac acattgatgt 2463181 aagttttctc gtgacgcctt ctttcatgat tttttccgcg taatggcccg gatcaaccac 2463241 atttaggcca agcatcatcg catcatgggc cacatggaag tataaatctc ctgtgacgta 2463301 aacatcggct ccctttcgtt ttgcatgatg aatatacttg tttccatctc cgccaagaac 2463361 agctactttt ttcaccatgc tgtcagcatc cccaaccatt ctgacaccat tgacgtcaag 2463421 cttgtctttc acaaataaag cgaattcctt gagcgtcatc tcatttttaa gggttccgac 2463481 acggccgagc cctttttcgg cgggagtctg ttcgacagga tagatatcgt aagcgacttc 2463541 ttcatatgga tggcttttta tcattgcatt gataacagcc ttttcgacgc ttttaggaaa 2463601 tacagtctca agccttactt catgaacaag ctcaagctct cccacttcac cgataaaagg 2463661 cttagctccg tccaatggct taaagctgcc gattccttca gatgaaaacg cgcaatggct 2463721 gtattcaccg atatggccgg cccccgcatt tccgagcgcg gctctgacct gctcttcata 2463781 ttccttcggc acgtaaactg ccagcttttt cagaggatcc gtataagtag gtgccagcac 2463841 ttccgtctca ctcagctcta atgcttcagc aagcaaatca ttcacaccgc cgtccgcaac 2463901 gtctaaattt gtatgagctg cataaacagc aatatcatgc ttcaaacact tttcaattaa 2463961 ccttccggca ggctgatctg ttgaaatatg ctttagcgac cggaaaattg gtggatggtg 2464021 tgcaataatc aagtcaacct ctttttcaat cgcttcatcg ataacgctct ctaacacatc 2464081 aagtgtaacc atcacatttt taattggttt gtttaaggtg ccgatttgca ggccgatttt 2464141 atctccttca accgcatagg ctttcgggga aaattgttca aacagctgga tgatctgctg 2464201 cccatttaca cttttagcca tgatcgatta cctcctttaa cagctccatt cgatcggcga 2464261 gctcctttaa tttttgtttg ttttgctctg tatccgccgc ttggctgatc tgttcataaa 2464321 tgctttgagt gtgctgaagc tcttgtgtcc actttttcaa aaagacagca tttttttctt 2464381 ttgccaagaa agggccaacg agcatcccgg ctgataaaga aataccgtca taagccgcat 2464441 ccctgtctcc cgcttctgcc accagcacct catagcactt tccgtcctct tcaaggatta 2464501 cctcatctat cagcgcatat ctttctttat aaagccactc cctgatatga acagcatgaa 2464561 tattcggctg taaaatgagc cgttccttcc ccgttaattt gtctttgccc gcttctaaaa 2464621 tgtgagcgat caaagccccg cccattccgg caatcgtaat ggcatcagct tcaccttttt 2464681 taatcacttc cagtccgtct ccctgcctta cagaaatgtg cgagtttaag cctgattttt 2464741 caacctgccg ctttgcagac aaaaatgggc cgtctgttat ttctccggca atcgccccgc 2464801 tggctttatg attcagcacc gcataacaag gaaggtaggc gtggtcagag ccgatatcgg 2464861 ccatcaccgc tccattcggt atgtactccg ctactgtttg caatcgttta gataatttta 2464921 attcgttcac ttgtcatcac aacttttctc aatcattttt tcctttacta tcatataaaa 2464981 aatcagcccg gaatccaagc tgaagcaaat gattttgaaa ttatttcttt tgatgcgggt 2465041 ctgcacgcag cagtcaaaaa taaaaggctg tcgagaacat ctcggcggcc tgtgaatgta 2465101 taaagagaaa aatagttctt ttatttaatt tttgacaccc actctgccat atcatccagc 2465161 ttatcggccg gaacaagacc ggaaggcatt ccattaccgc ctttttcgat ctttgtttta 2465221 atttcagcga catctttctt atcccctaca ccttttaagc taggacccga aacaccttca 2465281 taattttcac cgtggcatgc gatgcagttt gccttgtaaa tttcttctgg tgaagcgttt 2465341 gcatctttct tttcagcaga tttgctttct cctccgctcg caatctcccg agagtcatca 2465401 agtcctttta ctgataaaaa gaaagttaga ccaattccta aaacagcgat cagcaaaaat 2465461 ggaataagcg ggttccattt catttccctt cccccttttt gatccttccc cctatgtaaa 2465521 cacttctaat tctaacttat ttttacaaaa agtaaatgga ttgctataca aaagtttttt 2465581 attcacactt tatacaaaat tgaatagaaa catgcctaaa tctctaatat cctttttatt 2465641 ctattgtata atgtattgta tacgcttaca atagaaaata tggaattaga ttttgaaatt 2465701 tttcaccaca atgttcattt gcaaatgaca tcatttttca gtaaaataaa ggcatattat 2465761 ccatatatct ttttaaaaaa agaagaacgg atcttcaaga cccgttccat cttattcaag 2465821 gaaatctttc aaacgtttac ttctgctagg atgtcttagt ttccgcaacg ctttggcttc 2465881 gatttgtcga atacgctctc tcgttactcc aaatactttg ccgacctctt ctaatgttct 2465941 tgtacggccg tcatcaagac cgaatcgaag acgcaataca ttttcttcac gatcagttaa 2466001 cgtatcaagc acatcttcca gctgctcttt caatagctcg tatgcggcgt ggtcagaagg 2466061 tgaagttgct tcttggtctt caatgaaatc accaaggtgc gagtcatcct cttcaccgat 2466121 cggtgtttcc agagataccg gctcttgagc aatctttaag atttcgcgta ctttttcagg 2466181 cgttaaatcc atatcttccg caatttcttc aggtgttggt tctctgccta agtcttgcag 2466241 taattgacgc tgcacacgga ttaatttatt aatggtttca accatatgaa cgggaatccg 2466301 gatcgttctc gcctgatcgg caatggcgcg tgtaatcgcc tgtctgatcc accacgtagc 2466361 atacgtactg aatttataac ctttgcgata atcaaatttt tcaacggctt tcatcaggcc 2466421 catgtttcct tcctggatca gatcaaggaa cagcataccg cgtccgacat accgttttgc 2466481 gatactgaca acaagccgca ggttcgcttc agccaatctg cgtttagatt cttcgtcacc 2466541 ttcttcaatc ttttgagcgt aggcgatttc ttcttttgca gaaagaaggt taacccgacc 2466601 gatttccttt aaatacatac gaactgggtc attgatttta acgccaggcg gtacacttag 2466661 gtcattaagg tcaaattctt cttcggcttt ggcaagctgc tgaatattag gatcttctgt 2466721 ttcttcattc tcactaatta attcaacacc ttgttcacct aaaaattcat aatactcatc 2466781 catttggtct gattcaattt caaagctgga catacgctca gcaatttctt catatgtcaa 2466841 aacgccacgt tttttaccag actctgttaa ttgctctttt acttggtcga atgttaattc 2466901 tgtctcgtgg gtttgtttat cagccattat ggatccctcc ttccaaagct tgcaacgaat 2466961 tctataagcg gtatgattct tattcggtcc attcaggcgt tttctatgtg aactgccttt 2467021 aacaatgtgc gaataatgaa atgacaattc atgatgaggt taagcgatct atttgctcct 2467081 ccgcaaggaa tcattgccaa taaatgctcc tcatcagttc tccagttatt ttaaagatcg 2467141 gttcaatgta acgatttctt gagccaaaga agcagctctt aaaaaatctt tttgcctttc 2467201 tgcttcggct ctttccgcct ctttttcttt tatcattgac caatttcttt gattcaacac 2467261 tttttttaca taatctgata actcggcttc gctaagctct tgattaacct gaagcattaa 2467321 tatatcggac aagagctggc ttatatgatc atccgtcacc ctggccatca gatgctgagg 2467381 cgtcagctcg gctccctctt cataaaaagc ataaagataa gcggctaatg cccggtgctc 2467441 atcaatatta aattgaaacc ctacccggtc aatcactttt ttgatgacgc tccgatctcg 2467501 aagcatgtga gcgagtaaca gcctttctgc attttcatac gccggacgca aacgtttttg 2467561 ccttgctttt gtcgtcagat gcgctcgccg cgttttagtt tcaccgctat tgtcagcagg 2467621 tttgttttgc ttgctgaaaa cagacagctg ctcagttaaa gactcctgtg aaagcgaaaa 2467681 ctctgaagca agctgcttta catagacttc ctgctctaga gaccctgaaa gcgtgctgat 2467741 ttctttcagt acgtctttaa tgtaagctag gcggtcgcct tcatcggaca ggttctttcc 2467801 ttttcggaaa tattgcattt tgaacgccat tacggtgaca cttgcgtcaa taatgtcgtt 2467861 tttaaatttt tccccgccga attttttgat gtaatcatca gggtccaatc cgtcaggaat 2467921 cattgcaact ctgactttgc agcctttttt ttgcagaagc tccgaagctt ttaaggtggc 2467981 ttcataaccg gctttatcag agtcatagca aagaatgatt tcttcgacgt ttcttctcag 2468041 gatcttgaca tgatcatctg taagagacgt tcccatcgtg gctatgcttt cctttacatc 2468101 cgagcttacg gccgatatga catcagcaaa cccttcaaat aagactgctc tttcctgctt 2468161 tctgatatga aggcgggcct tataaaaatt gtaaagcagt ttgcttttat gaaagagcgg 2468221 ggtttcagga ctgttcatat acttaggctg ctggctgcca agagccctgc ctgagaaagc 2468281 aacaacagcc ccgtgatgat catggatcgg aaacatgaca cggtttctga agcggtcgaa 2468341 atatccgctt ccgtcttcgc gtctgatcag gagacccgct ttttccattt gcgcctcact 2468401 aaatcccctc tttacaagga atttcgtgat aaagtcccaa gaatcaagag catagccaat 2468461 ctgaaattca ttaatcagct ctttcgtaaa gcccctagaa agcagataat ccagtgcctc 2468521 ttgaccttct tttgtattta ttaacaaatg atggtaaaat ttcttcagga gctcatgtgc 2468581 ctcagccatt ttttgttctc cagaagactc tggccgggct ccggaatgga ctgttatatc 2468641 atctggaaaa tcaatttggt atttgtcagc aaggtgagaa accgactcgg caaaagaata 2468701 gccttccatc tgccttaaaa aagagaaaac attgccgccc gctccgcagc caaagcaatg 2468761 aaaaatctgt ttgtcgggcg atacggaaaa cgaaggtgtg ctttctccat gaaaaggaca 2468821 gagtccaaag tagtttcggc cttgcttctt taattgaaca taatcaccta tgacttcaac 2468881 gatatctgcc gacttttgca cctgatccac aatttcatct ggtatccgat ttcccatctt 2468941 ataacactcc gtcgtacatt attcgatgct ttagtgcaaa atcccttcat cgttcgacag 2469001 gattttttgc agcagtgtaa taaatcgttc tcgatcttct ttattcaatt ttttaggccc 2469061 tttggcatat acgccttttc ttctttgttt gccggaaaaa tgacggccct ctagggcaaa 2469121 atcaatcgtg tcttccttgt aaagacgacc tctttccgac ataacagaga catttctgtt 2469181 caacagcaga gatgctaatc cgatgtcctg cgtcacaaca atatctcccg gtttcacgtg 2469241 atttgcgata tataaatcag cagcttcttt atgaggatca acatacttcc atttttcttc 2469301 attgcttctg gaaagctgat aatgttcaaa tgaagcgaca aaaagaactt gaacttcata 2469361 ctcggatgct gtttgtaaaa tttcatcttt taccggacaa gcatcagcat cgacaaaaat 2469421 cgtcttttct tgttcattaa gaagagtaat tctccatccc tccattaaac tcctgcataa 2469481 aagcaagcaa aatcgcacat cctttattat tgtggatgta tatgaatttg tcgaaaaatt 2469541 tccgggagaa attcttgaca tcttacccat aatagtttat tcgtatcaca cgatccttaa 2469601 acctaaaatt aatcatttta tcacaatttt ttattataat acaaacttca caaagatgct 2469661 attgtttttc attattccct tttggcacag ccaaaaaccc aggatagagc gtcctgagtt 2469721 atatgttttt tgttttgaga tgatggataa tatttgctgt ttcctcaacc gctttatttg 2469781 aaacatcaac aacctggcag ccgatccgat ccacaatctt ttcgaaatac tcgagttcct 2469841 ctttgattct gttgatattt gcataaatcg ctttatcatt aagcccgagt gattttaaac 2469901 gttcttttct gatatgattc agtttatcag ggctaatctt taaaccgatg cattttttcg 2469961 gatcaacgtt aaagagttct tccggcggat caacctccgg tacaatcgga acattggcaa 2470021 ccttcaggcg tttgtgtgcg agatattgag acagcggtgt tttagacgtt cttgacacgc 2470081 cgatcaaaac gatatcagct tttaaaatcc ctcttggatc acgtccatca tcgtatttaa 2470141 ctgcaaactc gatggcctcc acttttttga aataatcttc atcaagctgg cgcacccgcc 2470201 ccggttcgta tttcgctgtt aaaccgtagg ctgtttccat tttatcaatc aacgggccga 2470261 taatatcata atataaaaca tttgcttttt ccgcttcggc tatcaaatat tctctgattt 2470321 ccggcaccac gagtgtaaaa cagataatgc cgccgtctgc ctttgcaagt gaaatcactt 2470381 cattgatagt gcctatatct tcaacataag gaattcttct tacatgagta tcatccgccg 2470441 atccgttaaa ttggctgagt gctgctttta ctaccaattc agccgtttca ccgacggaat 2470501 ccgatacaac atagatgatg cggttattca tattatcccc ccgttagttt gcaatcttat 2470561 aggatttcat tttcagataa actgacaagt attttggtca tatttgtttt tgtcactctg 2470621 ccgatcactt caaagccttt atcggtgtct ttgatgacag gcagtgcatc aatttgtttt 2470681 tctattaagt gctttgcaat gtccatcaca taatcctcgc gtctgcacac cgtaatgttc 2470741 ggcatccttg tcatgatgat gtgaacaggg accgatgtaa gctcctgctg gccaatgctc 2470801 gctctgagca agtcttttcg tgaaagcacc ccgactaaaa cagcatcgcg gtccaccaca 2470861 aacagagtac ctacatcttc taaaaacatg gtgcaaatcg catcgtacac agaaacgttt 2470921 tcgtgaatca ctacggggat agattgaaag tctttcacct gaagcttttt gagtttatcc 2470981 gccaaaagct gtgtgccggt ttttcccgta tagaaataac cgactctcgg gcgcgcctcg 2471041 aggaatcctg acatggtgag tatggctaaa tccgggcgca atgtcgccct ggttaggttc 2471101 agcttttctg caatatgctc ccctgtaatc ggcccgtttt cttttacaat ctgcaaaata 2471161 tgttcttgcc gtttatttag ttcgatcgta ctcaccacct tttcacttca tagctatgta 2471221 aagaaataac aatccatatt ataacgtaaa tatcttgtaa tcaaacaaaa aacttataaa 2471281 tggggaaaag acgattaccg atcacacagc aaccgccttt tctctcttta ttttacaata 2471341 agggcattca tattcgcaaa ggacttgatc tcatccgcca agcttaccat ttgcgctaaa 2471401 cgatttgcct ttaatgactc attatccgct ataaccattg tatgatcgaa gtaagcatcg 2471461 atcggttctt ttaaggctgc aagtgaagca agcgccgcct cataatcttt tttgctgaag 2471521 ttttcctgca gattttgctt cgctgtttgg taggcatcaa acagttttgc ttcgtattca 2471581 ttttcaaaca gatcaggctg aatgtctccg cggactcctt ttttgctgat agagatcact 2471641 cggcctaacg cttcggctgt ttccttaaag ccaggtgcac caagcttttg ctccagtact 2471701 tgtgctttat gcagcgcaga gtacggctca agctcagagc tttccagcac ggcgtcaatg 2471761 acatcatgtc tgatttgttc agcattcaag acatatttca agcgctgagt gaagaaatcc 2471821 agcagttcat tttctttatc ggtttgaacg aaagtaagca gctcttcaaa tgaaattccc 2471881 cagttgcggt caagaagaat cgcaacaata ccgcttgctt ggcggcgcag tccgtaaggg 2471941 tcctgggaac cggtcggaat tacgccgata gagaagaatg aagcgattgt gtcaagctta 2472001 tccgccattg ctacaacagc tccggtgaaa gtagaaggcg tttctccgcc cgctgatcta 2472061 ggcatataat gttcattaac tgccgcagcc acagcttcat cttcgccaag cattctcgca 2472121 tacttttcgc ccataattcc ttgaagttca gggaattcat atatcatatg cgtcacaagg 2472181 tcgaatttag aaatttcagc agcccgcttc acatgtttta atgtatcttc atcagcctga 2472241 agacgaacgg caagtttctc tgcgattgat gtgactctcc taaccttatc agcaagagaa 2472301 ccaagctctt catggaaaac gatattttca agcttcttca catttgcatc aatgtttagt 2472361 ttctgatctt ctttgtagaa gaatgaagca tcagataaac gtgcgcgcag cactttttca 2472421 ttgcctcggg ccacattttc aatcgcgtgg ctgttgccgt ttcggactgt gataaagtga 2472481 ggcagcaggt caccgttttt gtctttgaca gggaagtagc gctgatgctc tttcattgtc 2472541 gtgacaagca cttcttcagg aattgacaga aactcggatt caaatgaacc gtaaagagct 2472601 gtcgggtatt ctactaaatg attcacttca tcaagaaggt cttcgtcaac tggaatgctc 2472661 caattgtttt cagcagccat tgtttccagc tgagattgaa tcatttgctt tcggacgcta 2472721 ggatcagcaa taacatgctg tcctttgagc tgctcttcat aagctgaagg tgattcaatt 2472781 gacacttcat gtccgaggaa acggtgtccc tgtgttgtcc gtccagactc aacgtttgtg 2472841 atcgaaaatg gaatgacatc ctgtccaaat aatgcgacaa tccatttgat cggtcggata 2472901 taacgcaaat cttcatttcc ccagcgcatg tttttcggga aatgcaagct tgtaattaaa 2472961 ccgctcaatt ctggcagaag cgacttcgtt tcttggccgg cttggaattt ttgcacgaat 2473021 acatactcta tgccttttac ttctttgatg tacaggtctt ccacatttgc gccttggcct 2473081 tttgaaaagc cgattgccgc ttttgtccag ttcccgtccg catcaagggc aatttttttc 2473141 gcaggccctt ttgcttcttc ttttatatca tcctgctttt ctgcgacatc cttaacgaac 2473201 acagcaagac gtctcggtgt attgaagagt ttcacttcac cgtgagtaat atttttttct 2473261 ttaagccagc ctgtcagctt gtcgccaagc tgaaccatgc tttcattcaa aaagcgcgcc 2473321 ggcatttcct ctaatccgat ctctaaaagt aaatcctgtt tactcatgag aagaaccctc 2473381 ccctttaagc attgggaacc ctagtttttc tcgttcctca tagtaggttt ttgctacttt 2473441 tctagctaaa ttccgcactc ttgcgatata gcccgtccgc tcggtaacag agatcgcacc 2473501 tttggcatca agcaggttga aagtgtgcga gcatttcagc acatagtcat atgctggatg 2473561 aacaagtccg ttgtccattt gcttgatcgc ttctttttca tatgtgctga acaattggaa 2473621 cagcatatcg acgtctgatg tttcaaacgt ataaacagaa tgctcatatt cagccatcat 2473681 gaataaatct tttactgtaa accctgacgt ccattccaag tcaaacacgt tttctttatc 2473741 ctggatataa gacgcgagac gctcaattcc atacgtaatc tctacagaaa cgggtttaca 2473801 ctctaatccc ccgacctgct ggaaatacgt aaattgtgtt atttccattc cgtcaagcca 2473861 aacttcccag cctagacccg cgcagcctaa agacggattc tcccagttgt cttcaacaaa 2473921 gcgaatatcg tgctcaagcg gatcaattcc aagagcacgc aaggaatcca aatacagctc 2473981 ttgaatgtta tcaggtgacg gtttaataat gacctggaac tgatgatgct gatacagtct 2474041 gttcgggttc tccccgtagc ggccgtctgc cggacgtctg gaaggctcta cataagccac 2474101 tttccacggc tcaggaccga tactgcgcaa aaatgtatac gggctcatcg tgccggctcc 2474161 tttttctaca tcgtaagcct gcataagcac acagccctga ctggaccaat gcttttgcaa 2474221 ggttagaatc atgtcttgaa tattcatttc aagcacctcc acttttcttt cataagttga 2474281 ctgcggcagc aaccaaaaaa ctcccgtctc tatgcttgcc agccgcaaac atagggacga 2474341 gagttctccc gcggttccac cctagttgct gagaacaaaa tcccagcctc ttttttaaaa 2474401 ttgctcaaga atgcctttcg ttgcgtgctc atccttagct tacaccgccc taaggtcgct 2474461 ttcatgaggt aaacgcaagt acttctttct ctcactgcaa catattttat aataaatgat 2474521 catataaaaa gatggaccaa atgtcaactt ttgttttcac ccataagatg tttcatgctt 2474581 tccatttgat ctaaaaagcg ctttgatttt aaatacaatc ccgaatattc ttcgtaatat 2474641 aaatcaatca cttgctttaa ttcagctttt gtttcctctt ttaaggacac attgccgagt 2474701 ctcgacagat caaaatagta aaagagcctt aacagccttg ccgtttgcgg tttaatcggt 2474761 atcctgtaag gatctttttc aaaacagcgg tggcatataa aaccattatc acgaacagag 2474821 aaatgaaagg ttccgtcttg gcttttacaa tgtacacaat gattcagctc aggatacagg 2474881 cccatgacac cgagcatctt catttgaaca atgaaggtga taacatccgg atctgttcct 2474941 tcattcaact gttttaatga ttctaatatg aattcaaata aataaggatt tggctttttt 2475001 tcttctgtgc ctctgtcgac taactcagca acataggcag catatgctgt taaaaacaag 2475061 tcttccctga tgcctctcat gctgaggatc atttccccct gctgaagcgt tccgaggccc 2475121 gatgtttttt gcattaagaa agaaccatac aaaaagggct ggctgactgc tgataaacgg 2475181 ctgttcggtt ttttggcgcc tcgtgccata acacctattt ttccgtgttc tcttgtcagt 2475241 aatgttacga ttttattcgt ctctccgtaa tcatttgtgc gaagaacgat cccttcacat 2475301 tttgtcagca tttccgcacc ttcctcaagc aggagcggcc aagaggttta taaaattgga 2475361 taatcaaatc gggctagctc atcttctagt tcttcgggtc tttccatgtt ctctttttcc 2475421 agttctttaa aaagaagata cgtatcaaca tttcctgttt gagaaaatac gttccaggta 2475481 aaattcaaca caagaaaccc acctttctgt agttaaacta gcttacctaa actccaaatt 2475541 cttaccttta tcttgaccag atgtcctcca tttcatgtta aacaaaattt gctaatgtat 2475601 ccctgttcct gtgagataat gacacacacg ggaagagatt aatattcgtc ctctttaaag 2475661 ccaaaatcgc gaagctggga cattttatta cgccagtctt tctgcacttt cacccacaat 2475721 tcaaggtaga cacgggagcc caacagtgct tcaatatccg ctctcgctct ttttccaacc 2475781 tcttttagaa ggcttccttt tttaccgatc acgatgcctt tctgggaatc ccgctcgacc 2475841 acaatcgttg ccgctacgtg cacagaaccg ttgtcctgcc ctttgatgga ttcgatggcc 2475901 accgcaatgc tgtgcgggat ttcttctctc gtcaaatgca gcaccttttc cctgattaat 2475961 tcagaaatga taaatcgttc agggtggtca gttacctggt cactcggata gaattgcggc 2476021 ccttccggca aatacgcttc gatctgcgcg agcaaggttt cgatgttatt tccttctaaa 2476081 gcagaaatcg gaacaatttc cttaaaagga taacgtttgc ggtattcgtc aattagcaga 2476141 agcaattggt cgggatgaat tttatcaatt ttgtttacga ttaagaatac aggcgtagac 2476201 atcgtctgca atttctcaat gatgaattcg tcgcccttcc cgtagccttc ctcagcattg 2476261 atcataaaca agatcaaatc gacttctttt aatgtatttt gcgccacttt catcataaag 2476321 tccccaagtt tatgcttagg tttatgaatc cctggtgtgt caataaaaat ggtttgtgat 2476381 gtgcctgtcg tcagtactcc ttgcaccttg tttctcgtcg tttggggctt atcgctcatg 2476441 atcgcgattt tttgtccaat gactctgttc aaaaatgtag attttcctac gtttggtctt 2476501 ccaataatgg atacaaatcc tgatttaaag ctttcgttcg tcatgtaaat cctccgatga 2476561 aaatgcgcct ggcaataatt cttccacagt catttctttt atttgtcctt gtaaattagt 2476621 cagtacgaca ataacgtctt ttgtgcaaag ctcagaaatc acctgtcggc aggctccgca 2476681 cggagatact ggtccagggg tgtcagccgc aacggccagc atctgaaact ctgtatcccc 2476741 ttcagaaaca gctttaaata aagcggtacg ctcggcgcaa ttgcacatgc tgtatgccgc 2476801 gttctcaata ttgcagcctc tgtacacttt tccatccttg gtaagaagag cggctcctac 2476861 ttggaatttg gaatacggcg catatgccat atcacgcgct tttaaagctt ctgttattaa 2476921 ttcttgtctg ttcatgtgta cattcctctc ttacctataa tggtaccgct atcactttat 2476981 attttacata atcgcgcgct ttttttcacg cccatttcta aaaatgtaaa ataaatgtaa 2477041 gaattttcag ccattacagc tttggcaaaa aaataagtaa accaatgata cacgaaatca 2477101 cggcaaaaac gcaaacagcc ccggcggcag cgtccttggc cgctttagca agagggtgat 2477161 gtttgtcagt tattaaatca accgtatgtt caatggctgt atttaaaagt tcaagcgaaa 2477221 acataccacc tatcaaaagg aatataatca tccactcaat aatgctgagc tctacaagga 2477281 agccgcaaat gagaacagcg caggcggctg cggcatgaaa ttggaaattc cgctccgtcc 2477341 gcgctgtttc ccatatgccc cggcctgcat gcacgaagct tttgaagaat cgattcagct 2477401 catttctatg atcttttgag tccataagcg tccagcaatt ccttttgctt agtaaacatc 2477461 tcctcttctt cctctttcgt catatggtca tatcctaaaa ggtgcagaaa tccgtgtaca 2477521 gctagaaatc cgagctctct tttaaaagaa tgattatact cctctgcctg ctctcttgtg 2477581 cgatcggcac tgatgataat atcacctaaa accggaggca tttcggcgcc cacgatttcg 2477641 atctcgcctt ctccctcttc ttcaagagca aatgagatga catctgtcgg agcatccttt 2477701 ccccggtatt ctttgttaat ctgatgtatg tcatcattgg aaacaatcgt gacagaaact 2477761 tcagcctgat cctgaacgcc ttcacgctca gcggcaaatt gaagcagatt ttctacttct 2477821 ttgagcatct cttctgagac gcttcccgtt tcatcaacga tatcaatcag taaactcatc 2477881 tatttcacct tcttagtagc ctccggatat tcaatccggg agtggaaaat tccttttaat 2477941 gttgcacaga gcgtttttgc gattgtatcc agctctttaa atgtcaaatc gcattcactg 2478001 aactgtccgt cctgaagctt atcggatata ataccccgga caagcttttc aattcgttca 2478061 ggatttggat tgtgcatgga tctgacggcc gcttcaacac tgtcggccac tgatataatt 2478121 gcggcttcct ttgactgcgg cttcggtccc ggataacgga actcttcctc tgtaatctgg 2478181 tcgccttttt ccttcgcttt atagtaaaaa aactttaaaa gcgaggttcc atgatgctgc 2478241 tcagcaatat cgacaagctc tttcggaaat ttatagcttc tcagcatatt cgcaccgtct 2478301 gtcgtatgcg agataataat atttttgctc aactgaggtg acagcttgtc atgcggattg 2478361 tcaatattca tttggttttc aataaaatat tgcgggcgct ttgtttttcc gagatcgtga 2478421 taatatgcgc cgactcttgc aagcaaacca ttagccccaa ccgcttcaca ggctgcctct 2478481 gataaattgg caaccattac actgtgatga tatgtacctg gtgtttccgt cagtattttg 2478541 cgcaatagcg gatggttagg attagacagc tcgagcagcc tcatggtgga taaaatgcca 2478601 aagcccgtct caaaaaacgg catcagaccg atgatcaata cagatgaagc aaaccccgac 2478661 acaaccccca tgagcattaa cgtgccgatt tcaagacccg acagcgcagt gttctggatc 2478721 aataataagg atagaacgac aaccatatta ataaacgcca cgaaaagtcc ggtctgcaaa 2478781 atctttgatc ttgcattgtg ttttcctaaa aataatacac ctgaaatgcc gctgatcaaa 2478841 taataaatcc ctatgacata attgaatgtt cctgtcacac cctgattaaa catcatactt 2478901 ccgcaaatcg caagaatgat acttcccaaa atggcaatgc gttcattcat cagcagtttg 2478961 attaagatgg cgccggccgc aatggggacc agatagccga tattattata ctccatcttc 2479021 tgaaacaaac tgacaacctc catgatcaca agcaaaagtg ttgtgattat ggagaataac 2479081 agaatggatt ggtttttaaa cttcagattt tgtttctgtt tttcaaaata atatacaagt 2479141 gttgcaatga aaagtccgat cataatcaat agcccgctga tcggtttaaa gagatttgag 2479201 ttatttaata acccggtcag ctcaagtttc ctgtacactt cccgatcaat gaggtcattt 2479261 tcttccacga gcacttgccc ctgtttgatt tgaacctgct ggacattatc tgaggcttcc 2479321 tgccgttttg cctctgttgc tttcggatcg aagacgtaat tcggaataat agcaaaacgc 2479381 ccgatttctg tcgcggctcc caagtattta gacggaatag aattgctctt tagctctttt 2479441 tctaccttat cctttgcatc agatagttta tccgaaggga tttcactgct catgaccgta 2479501 tttaccgcgg taatgaccgt atctctgaca aaagaaaagt cttcactgtc tgctttcagc 2479561 aatgtcttga tggaatcctc cgatatagaa tcattcacat ctgatgtcaa tttgtccttt 2479621 acagatttga ccattgattt ttccgatggt gatttactgc cttcttccga tgattttttc 2479681 acttcactaa tactgtcgaa tattgatgac acaaggtcaa tccgattgtc tgtatattct 2479741 ttttttaatg tatattgatc ttcaaccgcg tcctcagcgg cttgcttttt ttcctctgtg 2479801 gctttttgat cttctacggt tgccggagcg taaatggtct tgtcgctgac tgaaaacagg 2479861 tctaaatcaa gtgtttccgg cttaacatgt acaaagagca aagcaaacat aatggcagcc 2479921 agcagaagat acagcagtac atgcatggag cgggcatttt taaaactgct ccattttttt 2479981 gagctgcttt tggtcttagc cttctttttc aacacaagaa cctcctcttg aaacatcaag 2480041 cccataagca atcataaaaa tgacccgata acgcgcgatc gggtcattca gcattaattt 2480101 tgcttatcgt atgcttcaat aattttcgca acaagcggat gtctgaccac gtctgtctgg 2480161 tctagctcaa tcatagaaat gccgtctatt cctttcagca tctccttcgc tactgcaagt 2480221 cccgatttga cgcctttcgg cagatcaatt tggctaacgt cacctgtaat gatcatttta 2480281 gagccaaaac ccagtctcgt caaaaacatt ttcatttgag caggcgtggt attctgtgct 2480341 tcatcaagta taacataagc atcatcgagc gtccgtcccc tcatatatgc gagcggagca 2480401 atttcaatga tgcctctttc catcagacgt tctgtatgat ctgccccaag cacatcatgg 2480461 agagcgtcat acagcgggcg caaataagga tctacttttt cttttaggtc acctgggaga 2480521 aaaccaaggc tttcaccggc ttccacggca ggtcttgtta aaatgatttt tttgatatgt 2480581 ccgtttttta aagcatggac tgcttttacg acagccaggt acgttttccc ggttcccgcc 2480641 ggaccaatgc cgaatacaag gtcattccgc ttcatagcgg ccacgtattc ccgctgtccc 2480701 attgttttta cacggattga tttgcctttt gcgttttttg taatttcttc ttcatacatg 2480761 ctttcaaagt attcaagttc attcttcttt gccattttga tggcgtaaat cacatcacgt 2480821 tcagagatct ctatcccctt gcgaattaaa gcgaggagcg atcccagcag cctgtctgca 2480881 atctgaaacg attcatcatc gcctgaaaca taaatcgtct cgccgcgcgt aatgatattt 2480941 aaattcagat ctttctccat caatttcaaa aaagaatctt ggttcccgaa gagtgaaagc 2481001 gcctcgtccg ggtttttcag tttttgattc atcgcaagta aatgttctgt cattcttcag 2481061 tctccctgac aataggtgtg gtttgaacga tatcttctat aacttggtag agaataatca 2481121 actttacttt accattctca acagtctggt gcaaaacttt ttcacttttc acctcgccgt 2481181 tttcgcctat tttatcctct acatcctgtt tacccaattt aatgccttct tgaactgctt 2481241 cttcttttgt atattttcgc aaagcctctt cactttctct cgtttgctct ttgacatagg 2481301 atacagggag cttaaatccg agaaaatgaa gcgaatgctt ttcttgttct gtttttggat 2481361 gcttcaattc ctctttttta aacgtcatcc cccagatcgg gattgccaaa gaaccaaaag 2481421 aaagcttgtg ctttgtcctt actttgcccg tatagacgtt aaataatgtt tcaagcggga 2481481 ctgtcacttc tgatctatac caggtttctc cataaatttc tgcttttgag gcgacttcct 2481541 gctgatggtc ttcgctgccg atcagtcccg aaacaagcag ctgtcccttt tcaacatgat 2481601 cgtgtatggc ggccatgggc tgtccttttt gcacaaacat tctcgtaatg gttgctttct 2481661 ttttggcgac aatattgcgc gggctaacat atttttcttt ttcgggctca tttttctcca 2481721 caactttcat atgaatggtc gtccccttca gatcaactcc gacccaagtg atattgtcta 2481781 ttccattggt taatgatttc tgtatttttt cgggcgacat cattaaaaac tgcagacggc 2481841 cctttttgac gccgatttca ttaagatgct gcctcatttg atgttctgtt tcaggcttag 2481901 cgcctgtcac atcaattttc cacaccatat tggacagcaa aaacaaaaga atgaaaaaaa 2481961 tcgcaaaacc gatcgtaaac cctatattca gctttgattt cagcaacagg aagggaaatc 2482021 ccttccgatt gataaatcgg gctttacatt taaatttact tcttacccgc cgaaaggcat 2482081 gtacatcctg aagctgtata tataacgata cggcttcttt cttttttttg acatgaaaga 2482141 ccggaatccc ctgtcttgtg cattcattaa ggagccgctc aatccctctt cccgtcaatt 2482201 caagctggac cttacccgaa aaaaaagaca gccatttatt tttcacaaca tttccccctc 2482261 ggctttatga ctcaacatat cgaacgacat caatcgtacc ctccaaaagt atctcttccg 2482321 gaagaatcgc cttgatgaca aaatttttac cagatatgat gcactggccc tgcttcagca 2482381 tcagccgcac ttcattctca ctgaaaagca aaaggcctct gtggttttct atgtagatat 2482441 gaagtctgcc aaccattgta atcctcggca gatccatcat aacgtccggg ggaatttcca 2482501 atgctcttgt cagccaagct ttcatacgat tctttctttg ccccatacaa aaagaacccc 2482561 ctttcatctc atatgtatga tttgaaagga ggttctaaca ctttaatttt tacgggccgg 2482621 gcgcatcgta cggtgaggtt ttttcgcccg tggaggtccg aacacctctc ctagaacgat 2482681 cccctgtacg acggtgtctt tattcacctg aagcattttt tgttttgtgt atactgtttt 2482741 ttgtttggca gcagcaagat ctcgttccag ccctttcagg tttcttgctg tttccctgcg 2482801 tctttcttcc gcttcccgtc ttgcctgttc catacggtta gggataggtg caggggcatc 2482861 ttcttttgac tgcttctttt gaggagaagc agattgcacg tgttgaggtt tttttctttt 2482921 ttggctgttt tgcttttctt ctttgctctt tttgccgaaa atcgcagaaa tgattccgat 2482981 gatcgctgca ataataagcg gattggtcag taaatcttcc atcagcgttc tcccttctta 2483041 gagagattat gatttgcggt cttcatccga agggtctttc gtcagcttgc cgaatgaatc 2483101 acgcatttct gtgtcagcat cgatgttctt gatattcatg taatccatga cgccaatatt 2483161 cccttcacgc aaagcttctg ccatcgcaag cggcacttcc gcctcggctt ctactacttt 2483221 cgcgcgcatt tcttctacgc gggcacgcat ttcctgttct tgagcgacag ccatcgcacg 2483281 tcgttcttcc gcttttgcct gcgcgatgtt tttatcagcc tcggcctgat cggtttgtaa 2483341 aattgccccg atgtttttgc cgatatctac atctgcaata tcaattgaga gaatttcaaa 2483401 cgcagttcct gagtccaatc cttttccaag gactgtctga gaaatcatgt cagggttttc 2483461 aagcactttt ttatgattat cagatgaacc gattgtagaa acgattccct cacctacacg 2483521 agctacaatg gtttcttccc ctgctccccc gacgaggcgc tcgatattcg ctcttactgt 2483581 gattctcgct ttcgctttca cttcaatccc gtccattgcg acgccggcaa tgaacggtgt 2483641 ttcaatcacc ttaggattaa cgctcatttg aacagcttcc aacacgtccc ggcctgcaag 2483701 atcaatggca gcacagcgct cgaatgtgag ttcaatgtta gctcgctgag cggcgataag 2483761 cgcgttgacg actctgtcaa cattacctcc agccagatag tggctttcaa gctggtttgt 2483821 tccaacatta agtcccgctt tatgcgcttt aatcagcggg ttaacaaccc gattcggaat 2483881 gacgcggcga agcctcatcc caactagagt gaaaatgctg attttcactc cggctgccaa 2483941 agctgaaatc caaagcatta caggcacaaa tgtaaaaaat actgccaaaa caatgatcgc 2484001 tactgcgaca attgccagaa tcataagtgt tgacggatcc atataacttc tcctcgtttc 2484061 tatttaaatt tctctcacga caatgcgtga gccttctact tttatcactt ttactttttt 2484121 atctttttct gtaaacgatc cctccgatac aacgtcaagg cgttcatcat caataatcac 2484181 ggtaccggaa ggacgcagcg gtgtaaaggt tatacccact tttcccatta agtccgtgcg 2484241 cgtttgattt gaaacgtagc cgctctccgt gtttgtagaa tcatttaata tcaatttctt 2484301 aaagaatttc atacgctttc ccaacaccct tgtcagtaaa ataaaagctg taatcgaaac 2484361 agctgaggcg atcaagagag aaaccgccat gacagtgaag ctccccgcgg ctaaaaacag 2484421 gctcgcaata atcgctccca agcccagtaa tccaatgatt cctccgggaa gaaaaatctc 2484481 aagcagaatg agaatcaccc ctgctataaa gaggagaacc gtctcatacc cggcaaggcc 2484541 ggctgcaaga tgcccgtaaa agaacagcaa taacgcaatg agtccagccg ttccagggag 2484601 gccgacaccc ggggaaaaaa gctctaccgt cagacctaaa aaagcgattg tcagcagaat 2484661 agggacaatg accggattcg tcagccatct tgccgtcttt tccgcaaagc tctcctttgc 2484721 atagctgatc tgcgcctttt cgaacccaag cttctttacg agcgtggaca aattgtcagc 2484781 agtgccttct gaatagccta cctcaatcgc cttgtctgcg ttaagtgtca gcagatctcc 2484841 cttaggcgcg ccaacttcct tggcatctat atctgggtca gccattgcga gcgcatattt 2484901 tggatcgcgg ttatttttca ctgcggcatc ttccatctct gccagccaaa gtgattgagc 2484961 tttttggtca gcggcattgc cttggccatc aacaatcgcg gcggctccca tttttccgcc 2485021 aggcgccata taaatgtgat ctgcttgaag tgcaatatat gcaccagcag acaacgcgcg 2485081 tttgttgaca tatgcagtta cggggatctc gctttcggtt atcaaatcgg ccatatcaat 2485141 agcagatttg accaatcccc ccggggtatt gatatcaaga ataatatggt ctgcatgtgc 2485201 atcctttgcg tcttgtaacg aacgggacaa aaacgaggcg agaccctgtt cgacattttt 2485261 ttcaaccggg atcacataaa cagtttgttt ttctgctttt gcgttcagct gtacgcctaa 2485321 taaagaaagt aaaaatatac ccaaaagagc agcacggaat cctttgattt gaagcaaggg 2485381 cggtgtatcc ctccttcctt ttataataag tgccttctct tcatacgtaa caaatgtatc 2485441 aaaggtttca tttttttatg tataaaaaaa gacatctctc ttagaaagat gtccttttct 2485501 ttgccattta agacagttga ctgctcacaa gcttattaat taaacttccg tcagctttac 2485561 cttttacttt aggcataatt gcccccatca ctttgcccat gtccgctttt gagctcgcac 2485621 cgacctccgc gatggtttca tttacgattg tacgcagctc ttcttctgac agctgctcag 2485681 gtaaataaac ttctaaaatg tccagctctt tttgaacttt atctactaaa tctaaacgat 2485741 tagcgtttga aaattcctgg agggagtctt tacgttgctt aagttcacga gaaaggacag 2485801 tgagttcctc atcctcggtc aaactgtctt tcttaagctt aattgcttca ttttgaagtg 2485861 aagccttaac cattcgaacg acagtcagtt tgtctttctc acggtttttc atatacagct 2485921 tcatatcctg gttgagacgc tcaagaagac tcataaatcc accctctttt agaatttgcg 2485981 ttttctagca gcttcagact ttttcttgcg ctttacgcta ggtttttcat aaaattcacg 2486041 ctttcttgct tcttgcaaag tacctgtctt tgatacactg cgtttgaagc gacgaagagc 2486101 atcttcaagc gattcgtttt ttctaacgac cgtttttgac attctctttc cctccctccg 2486161 aatacaccaa tcgactacct ttaagttaca catataaaca tgtactttga cattataata 2486221 taagccatca gtcaggtcaa ctaagtgagt tcacttttcc gtcatgagtg cgactgcctg 2486281 tctatataat gaaagaaagg ggttggtgaa taggatgtta attctgatta gctttactgc 2486341 tcttatatta ttctttctcg caggcatgaa catgcttcga aagggcttaa tttcaatggc 2486401 gtactcaaaa attgaagaac gtttgctttt atttacagac catccgttaa aagcgtttct 2486461 tatcagtatt gtatttacgg ggatacttca gagcagctca gcctttatgg tcattgtcat 2486521 cggctttgta agtgcgggcg ttctttcttt taagcggacg atcccgatga ttctggggac 2486581 aaatgttggc tctactttta caactgaatt tattgctatc aaaatggata ttgtgatttg 2486641 ggttctttta ataggaggtt tattgttttt tctgactggc aggtatcctt tgaaacagct 2486701 gggaacaagc ttccttggac tgggcatcat cttcttttgc atcagcggat tcagccatct 2486761 tgccgggccg ctgacaaagc tgaaaacggg cgccgacgtt ctataccatg ttaacgattc 2486821 aaactggtcc gctttgctca tcggcatggt gttaactgcc atcattcact ccagttctgt 2486881 ctgtatcggc attttgatga gttttatgaa tgaagggatt atcggactga cacaggcgat 2486941 gagcgtcgta ctcggatcaa atatcgggac atgcattaca gctgtcatgg ctgctgtatc 2487001 cggcggatat gcggcgaaac agacagcata tgcccatgtg gtatttaacg tgctaggggt 2487061 ggctctagta ttgccttttc tgaccgcagc gaccggcttt gtagagcagt tatcacctga 2487121 tcccgcacaa aagatcgcgc atttcagcct tttatttaat gtggtgacag ctcttttatt 2487181 tcttccgctt acaaacttgt tttaccgatt gattcacctt cttatcccgg ctaaataaaa 2487241 aaatcggtac attttaatgc accgattttt taggttaaga agacaaacgc atgtgttcag 2487301 ttatttcatc ctcaaccaca cggacaaact gtccttcgtt gtaaggataa cctgctttta 2487361 ggattttgac ttttacgatt ttgccgatca tatcttccgt acctttgaaa acaaccttca 2487421 tataattgtc tgtgtaaccg acaaacatat tttcttcttc tgtttcctta aacgcttcct 2487481 cagggataat ctcaagcact tcattttcat actgagaagc gtattctttt gcaagctggt 2487541 cagaaagagc aatcaggcgg tgcacacgtt cgtttttcac gttttcatcc acttggtctt 2487601 ccattcgtgc agctggtgtt cctgtacgct tactgtaagg gaaaacatgc agctcagaga 2487661 atttatgttc tttaataaag ttataggttt ccataaattc ttcttctgtt tctccaggga 2487721 acccgacgat gacatcagaa gtaacagcta agcctggcag tgcttttttc aatttattta 2487781 aacggtctgc aaagaattcc attgtatatt tgcgtctcat ccgtttaagc actgtgtttg 2487841 atccggattg gataggaata tgcaaatgat tcactatctt atctgagcgg tctaagacct 2487901 cgatcacttc gtcagtgatt tggctggctt cgattgaaga aattctgatc cgtttcacgc 2487961 cttccacacg ggtgtctaat tcgctcaaaa gcttcgcgaa gttgtaatct ttcatatctt 2488021 cgccgtagcc gcctgtatga atacccgtaa gaacaatttc cttatatccg gcatcgacaa 2488081 gctgctgcgc ttgtttaatg acttcttcag ggtcgcggga gcggagcagg cctctcgccc 2488141 acggaatgat acagaatgtg cagaaattat tgcagccctc ctgtattttc aatgacgctc 2488201 ttgtgcggtc cgtgaaagca ggcacatcaa gctcttcata tactcttgct ttcatgatgt 2488261 tgctgacgcc attaatcggc tggcgttctt ctcggtattg gtcaatgtag ccaagcattt 2488321 tttcacggtc ctgtgttccg actacaatgt cgacaccggg gatcgccata atctcagcag 2488381 gtgaggtttg cgcgtagcag cctgtgacac agatgacacc gtcaggattt tgacgaatgg 2488441 cgcgtctgat cacttggcgg ctttttttat ctcccgtatt tgtaaccgta catgtattaa 2488501 tgacatatac atcagctgtt tgttcaaagt ctcttctttc atagcccgct tctttgaaaa 2488561 gctgccagat tgcttctgtt tcataatggt tgactttaca gccaagcgta tggaaagcaa 2488621 cagttgccat tactgatcac ctcttaataa ctctgtttga taagaaatcg cactcaacgc 2488681 gtatagcgga gcggtttctg tccttaaaat tctcggtcca aggccgcacg tcacaccgtc 2488741 ttgctctgtg agccgttcaa cctccgcttc tgttaaaccg ccttcgggac caaatacgat 2488801 caatagagat gatcctttcg gaaggctgct tacaatcgcg ctgaatgcgc ttatttcccc 2488861 ttgcttcgat gactcctcgt atgcaacgac acatttatcg aaatcctgca tcctttgaag 2488921 aagctgctga aaagaatgga catccatcac tcgcggcact tcgttacggt acgattgctc 2488981 agccgcttcc ttcgcaattt tcgtccatct ttcccgcttt ttctttgcct ttttgtcatc 2489041 cagcttgaca acagaacgcg cggcttggaa aggaataaag gcatgagctc cgagctcagt 2489101 ccccttttgg ataatccatt caagcttatc tcctttcgga aggccgctcg caatatagac 2489161 ctttatcgga agctctctgt tttcattcgt ccattctatc acaaggcagg acactttatc 2489221 tttggaaaca gattgaagtt cacattttgc ctcgaagccg tcttgagagc agcagataat 2489281 ctgatctccc tcattcattc tcatcacgtt cacaatatga tgaacttctt cgccggtaat 2489341 cgaaaaagtc ggcgcttcct ctatttgctg cttcgtgagc tcgataaaat atcgttgcat 2489401 acgctgtgac acctactaac tgttattttt tcgcaataat gctgacccaa tcttccattg 2489461 aaaggatttc tacaatggta aagccagctt gttccagtgc ttcttttact tcttgttttt 2489521 tatgaccgat gattcctgac gtaataaagt gaccgccttc ttttaacagg ctgtacgctt 2489581 gtgaagtaaa gcgaagaatg acttcagcca aaatgttggc cacaatcaca tcatgttccc 2489641 cttcaatccc gtctaacaaa ttgttttgct tcacttgagc aatatcgctg actttgttca 2489701 gcttgagatt gaggcgtgca ctttctacag ccacgggatc aagatcgtag gcatgaaccg 2489761 attcagcctc aagcattgca gccgcaatac ttaaaattcc cgaaccagtg ccgacatcaa 2489821 tcaccttatc acccttttgc acaaagcgtt caagcgcctg aatgcagagt acggttgtcg 2489881 gatgtgtccc tgtgccgaaa gccattcccg ggtccatttc aataatcagt tcatcagtat 2489941 ggaccggcgt atattcctcc cacgtcggca caattgtaaa cttttcagaa attttcacag 2490001 gatgataata ctttttccag gcagtcgccc actcttcttc atttacttca gaaatagtga 2490061 tgtggtttct gcccaaatca atattgtaaa gaaggagatt attaatcgtt tctttgatgc 2490121 cgtctacagt ttcgcccaga aaactgttaa ccggcagata tgctttgaca atgacaccct 2490181 catctgggta atcattgggg tcgagctggt agatttcccc gtacacattc tcacgttctt 2490241 taattaaatc aagcgggtcc tctatcacaa ccccacttgc accagcttca tgcaatatat 2490301 ttgagatagg ttcgaccgct tcatgtgttg tgtgaatgct taattcggac catttcaaaa 2490361 ctaccaactc ctcatccaat aattaatcgc ctttaaacgc gcgttttacc ttgtcaaaga 2490421 aactcatttc ctgttcgtca ggcaggtttc cgctgacttc ggcaaattcg cggataatgt 2490481 ctttttgttt atcagtcaga tttgtcggcg taacgacgcg gacgacgata tgctggtcac 2490541 cctgtccata gcctctgaca ttttgaacgc ctttgcctct taatctgaat ttcgttcctg 2490601 tttgtgtacc ggccggaatt ttcaatttca cttttccatg cagcgtcggc acttctacct 2490661 catctccaag agcagcctga gcaaacgtta acggcatttc acagtaaata tcatcgccgt 2490721 cacgctcgaa gaactcgtgt gcgcgtacat ggaacacgac aaataaatcc ccggcagggc 2490781 cgccgtttat tcctggttca ccctgtcccg agagacgaag ctgctgcccg tcatctacac 2490841 cggctggaat tgtcacattg attttcttgc gttttttgat ttttcctttg ccgccgcagt 2490901 ccgcacattt gtttttaatg attttgcctg taccttcaca gtggtggcag acccgtctgt 2490961 taacgacttt tccaaacggt gtattttgct ccacgtttaa ctggccggag cctccgcagt 2491021 gggagcatgt ttctggattt gttccaggtt tcgcacctga gcctttacat gtttcgcacg 2491081 tttcctcgcg gggaatttcg atggttgttt ctttaccgaa agccgcatcc tcaaacgaca 2491141 gggtcatcgt atactgtaaa tcagcaccct ggcgcggagc gtttggatct cttcgtcttg 2491201 tgcctccgcc gaatatactt gagaaaatat catcgaaacc aaaaccgccg aaatcgccgc 2491261 cgccaaaacc tccgccgccg aagccttggt tagggtcagt gtgaccaaat tgatcgtaat 2491321 gcgcacgttt ttggtcatct gacagcgttt cgtatgcttc ttttacctct ttaaattttt 2491381 catctgatcc ggcttctttg ttaatatcag gatgatattt ttttgacagc ttccgataag 2491441 cttttttaat ttcatccttt gaagcgctct tacttactcc cagcacttca tagtaatcac 2491501 gcttactcat ctcgcttcac tctcccgaat ttctcacata aattagattg tatcattttg 2491561 aattatgatt tttcaattcc ttttatcccg ggcaagaaaa aaagtcaaag ccaagagatg 2491621 cctgactttg actttctaat cattgaatca gattatgaaa tgtgttcttt tcggtcagct 2491681 ccggaagcgg ggctgacact aaaaagaact tattttttgt tttggtcgtc gtttacttct 2491741 tcgtattcag cgtcgacaac gttgtcatcc gctttgcctt cagcgtttgc tccgccttga 2491801 gcttgctgtg ctttagcagc ttcttcataa agcttcatag aaagctcttg aacgattgtt 2491861 tgaagctcat cttttttcgc tttgatctct tcaaattcgt ttttctcaat cgctgctttt 2491921 aaagcgtctt tggcatcgtt ggcttttttc acttgttctt cgtccacttt gccttcaaga 2491981 tcttttaatg ttttctcagt ttggaaaaca agctgatctg cttcgttgcg gacttcgatt 2492041 tcttcttttt tcttcgcatc agcgtcagca ttttcttccg cttcttttac catgcgttcg 2492101 atctcttcat ctgagagacc tgaagaagat ttgattgtaa tgttttgttc ttttcctgtg 2492161 cctaagtctt ttgctcttac gtttacgata ccgtttttgt caatatcgaa agaaacttcg 2492221 atttgaggca cgccgcgcgg tgctggcggg atatcagtaa gctggaagcg gccgagtgtt 2492281 ttgttgtcgg cagacattgg gcgctcacct tgaagaacat ggatatcaac agctgtttgg 2492341 ttatcagcag cagttgagaa cacttgagat ttgcttgttg ggatcgtcgt gttgcggtcg 2492401 atcagttttg taaacacacc gcccattgtt tcgataccga gagaaagcgg tgtaacgtca 2492461 agaagaacaa catcttttac gtcacctgtg ataacgccgc cctgaatcgc agcaccaagc 2492521 gctacaactt catccgggtt tacgccttta tgcgcttctt ttccagtttc ttttttgatt 2492581 gcttcttgta cggcagggat acgagttgat ccgccgacaa ggatgacttt gtcgatttcg 2492641 cttgcagaaa gtcctgcatc ttgaagcgct tgacggacag gacccattgt gcgctctact 2492701 aaatgagaag aaagctcttc gaatttagcg cgagttaatg taagttcaag gtgaagcggt 2492761 cctgcttctc cagctgtgat aaacggtaaa gaaatttgcg tagaagatac gccggaaaga 2492821 tcttttttcg ctttttcagc tgcgtctttc aaacgctgaa gcgccatttt gtcttttgac 2492881 aaatcaatgc cgttttcttt tttgaattca gacaccagat gatcgatgat aacttggtca 2492941 aaatcgtccc cacccagacg gttgtcgccg gcagttgaac gaacttcgaa tacaccgtcg 2493001 ccaagctcaa ggatggaaac gtcgaatgta ccgccgccaa ggtcgtatac taggatcgtt 2493061 tgatcttcat ctgttttatc aagtccgtat gcaagcgctg ctgcagtcgg ctcgttgatg 2493121 atacgttcta cttcaagacc tgcaatttta ccagcgtctt ttgttgcttg acgctcagca 2493181 tcgttaaagt atgcaggaac tgtgataact gcttttgata ctgtttcgcc aagatagctt 2493241 tcagcgtatg atttaaggtg ttgaaggatg atagcagaca cttcttgtgg agtgtaatcc 2493301 tttccttcaa tttcaacttt ataatcagta cccatatgac gtttgataga cataattgtg 2493361 ttagggtttg taatagattg gcgtttagcc acttccccta cttgacgttc gccgttttta 2493421 aatgcaacaa ctgatggcgt tgtgcggttt ccttcagcgt tagcaataac tttaggctcg 2493481 ccgccttcaa gcactgccac acatgagttt gttgttccta agtcgattcc gataacttta 2493541 ctcacttgaa taacctcctg ctatgtaatt attgattcac tttgaccatg gaagggcgaa 2493601 tgacgcgatc cttcagctta tagccttttt gcatttcctc aacaacaatg ttggagccgt 2493661 agttttcgtc ttcagcctgc ataacagctt ggtgcagatt aggatcaaat tcctgcccta 2493721 cagcttcgat ggcttcgacg ccttcttttt tcaaggcttc tacgagctga cggtggacca 2493781 tttccattcc ctggagcaaa cttttcgtct gttcattgtc ggcttcaacc tgaagcgctc 2493841 gttcaaaact gtcaagagcc ggcagcaaat cagtcacgat attttgagaa cggtattttt 2493901 gggacgcttc catctctaaa cggctgcgtc gtttatagtt ttcaaagtct gcttgaacac 2493961 gcaaaagttt gttttctttt tcctcaagca aaccttgcaa ttcgttaatt tggttttgaa 2494021 gaagttcgct ttcatttgtt tcttcctgct gttcatcagc ggcagcttgt tcttcaatga 2494081 tttcttgctc ttctgtttcg ttttgttcaa cggtttgttt ttcttctgac attgtgttca 2494141 cctccctcaa agtgtaagga gaaggacagg tgctgccctt cgataaaatt tgccaaaatt 2494201 cccttattca tcatacagac ttgttaatgc ttttgacaag tccgaagtca catgctgaag 2494261 caggctgaca accctggaat aattcatgcg ggtcgggccg ataatcgcaa ttgagccgat 2494321 ctgcttctgg tctacggaat aagaagccgt aatcagactg caattttcca tctcttcata 2494381 gtcgttttct tttccgattt taatcgaaat tcccgtgtgc ggggattgaa ccagctttaa 2494441 aacatcctgt tctttctcaa ttaatgaaag cagcgaccga actcgggtga tatcatggaa 2494501 ctcaggctgg ttcagcatat tgattttccc gccaaaaaac aacttttcaa cgtgatttgt 2494561 ggaatgaaag gttgaacgaa gcgcgtcgag tatattgtca tagtttttaa tgtgctgtct 2494621 taggtacatg acaacttctt taaatatgcg ctcattcagt tcatccattg gaacgccgct 2494681 taaacggtcg ttcagtatat ttaccagttt ttcaatatca gacagatcca ttttggtcgg 2494741 aaagttaatc gttttgtttt ccacatgccc cgtattggta acgagaatcg ctaccgccat 2494801 atcaggctga atcggaatga tttgaatctg tttaaggtaa ttctcactca acttcggccc 2494861 gagtacgatg gatgtgtaat tcgtcagatc ggacaaaatt tgcgctgatt tttgaactgt 2494921 cttctccagc tcgaaaattt tctctttgaa gatcgagtgg atttggtcca ggtcgctttt 2494981 cgtcaatttg acgggtgaca gcaaatggtc aacatagtac cgataccctt tttctgacgg 2495041 aacacgtcct gaggatgaat gggttttttc aataaagccc aattcctcca agtcagccat 2495101 ctcgtttctt attgttgcag agctaaatgt gatttcatct tttttcgaaa gagttcttga 2495161 tcccaccggc tgtgccgatt taataaaatc gttgattata acctgaagga tcagcagctg 2495221 acgatttgtt aacatcatca tcacctctgt tagcactctc aataagcgag tgctaattct 2495281 ataacaaaag tatcaaacca caagaaaaat gtcaattata actcacccaa aaaagcgcca 2495341 aaaacttcat tgcctaataa tttcccttga tgagtcaaat aaacggcaga ctccgaattg 2495401 tgaatcagcc ctttttcagc gaggtctttt aacacgcttg ggaaaagtcc atccagggaa 2495461 cggccgtatt tttctgcgaa tcgttttttg ctgacaccgg ctgtttttct caaacctaaa 2495521 aacatttctt cctcaatctg ttcttctgtt gtcacttcat gtgtatctct gtacggaaaa 2495581 cccttttcag ctatcaggtc aatgtaatgc ttaacaggtc cgacgttcac tgttcgtgtg 2495641 ccgccaatat atccgtgagc gccagctccg aaaccgaaat attgttcgtt gctccaatac 2495701 gttagattgt gcttagattc catgcctgcc ttagcaaagt tgctgatttc atattgatga 2495761 atgccgtgag cttccatctt gctcatcact atttcataca tttcagcttc ctgctcctgc 2495821 ggcggaagat gaagccgccc tttttgcatc aaattataaa ataccgtttt cggttctaca 2495881 ataagggagt aaacggaata atgctcagcg tccaatgata aagcagtgtt tatggaatgt 2495941 tccagatgct tgagggtttg ccccggaagc ccgaacatga gatcaagact gatattctca 2496001 aaaccgattt cccgcgctct ttcaaaagag gtgaatacat ctttttgctt gtgcactcgg 2496061 ccgatttttt ctaacagatc gtcttcgaac gtttgcacac caaagctaag gcgatttacg 2496121 cctgcttctt ttaatatttt taatttctct gcggacaaat cgtccggatt cgcttcaacc 2496181 gcaaattccg ataagtcgct tgagggcttt agcacgcggt tgatcatatc catcagcttt 2496241 ttaagctgtt cctcagacag ggaggtcggc gtgcctcctc cgataaagat tgttttgaga 2496301 tcaggctgcc cggtttttgc tattgtattt atcatttcct gttcgagtgc gtttaaatac 2496361 tcgtcgactg gctgactttg aataaaatat ttattgaaat cgcagtagtg gcaaatatgc 2496421 tcacaaaatg ggatatggat ataagctgat ttcaacggat tcaccttctt tacagaaaga 2496481 agccgcagta caagactgcg gcggcttcta ttgttttttc ggactgtcgt ccattttcag 2496541 aactgccata aatgcttctt gcggcacttc aactgagccg acctgcttca tacggcgctt 2496601 tccttctttt tgtttttcaa gaagtttccg tttacgcgag atgtcccctc cgtaacattt 2496661 agccaatacg tttttacgca ttgcttttat ggtggagcgg gccacgattt tctggccgat 2496721 tgcggcttgt accggaactt caaactgctg gcgcggaatg agttctttca gtttttcaac 2496781 gatcactttt ccccgttcat atgcgtaatc acgatgcacg ataaaggaaa gggcatcgat 2496841 tttttcacca ttcagcataa tgtccatttt cacaagcttg gacggtttgt agccgatcag 2496901 ttcataatca aaggacgcat agcctttagt gcttgatttc agctgatcaa aaaactcata 2496961 tacgatttcc gctaatggca tatcataaat gatgctgaca cggtttgcgt ctaaatactg 2497021 catatcaatg aaattgccgc gttttccttg gcaaagctcc attacagcgc cgacatagtc 2497081 attcggcacc atcatcgtcg cttttacgta tggctcctca accctttcga tcttttgagg 2497141 atccggcatg ttggacgggt tgtcgacaac gaccttttcg ccgtctgtca tatacacgtc 2497201 atagataacg cttggcgctg tcgtaatcag gtcgatgttg aactcacgct caattcgctc 2497261 ctgaatgatc tccatgtgaa gcatgcctaa aaatccgcag cggaacccga atccaagcgc 2497321 ttgcgaagtt tccgcttcat attgaaggga ggaatcattc agctcaagct tttcaagagc 2497381 ttcccttaaa tcattatact tcgctgtatc aatcggatac aaaccacagt acaccatcgg 2497441 gtttagcttg cggtatcccg gcagcgcttc ttctgcagga ttggcagcgc tcgttattgt 2497501 atcaccgaca cgtgtgtcac caacattttt gattgaggca gtcaggaagc ctacatcacc 2497561 gaccgtcagt tcatttgtcg gagttgcttt cggcgtgaac acgcccacct ctgttacttc 2497621 gaattctttg ccggttgcca tcattttgat tttttgtccc ggctttaccg ttccttcaac 2497681 gactctgata taagccacga caccgcggta ggcgtcataa agcgagtcga agatcagcgc 2497741 tttgagcggc gcctccggat ctccggtcgg agctggcacc ttttctacga tttgttctaa 2497801 aatctcctca atcccgatac cggcttttgc tgaagcaagc acggcttctg atgcgtcaag 2497861 gccgataacg tcttctacct cttggcgcac acgttcgggc tcggcgctcg gaaggtcgat 2497921 tttattgatg accggaagga tttcaagatc gttgtcaagc gctaagtaga cattggcgag 2497981 cgtctgcgct tcaatcccct gggctgcatc cacgacaaga atcgctccct cgcaggcagc 2498041 aaggcttcgg gatacttcat acgtgaagtc gacgtgtccc ggcgtatcga ttagatgaaa 2498101 gatatattct tctccgtctt ttgctttata tttaagctga acagagttta atttaatggt 2498161 tatgccccgc tcacgttcaa gatccataga atcgagcaat tgttctttca tttctcgttg 2498221 agtgattgcc gacgtttttt ctaaaatacg atccgctaag gtcgattttc cgtggtcaat 2498281 atgggcaatg atagagaaat tccgtattct cgattgcctc tctaaacgct tttctttatc 2498341 tgtcacaatc tatcactcct actattaaac gcaaaataca ctagcttaga ttatatcaat 2498401 aggattgtaa agattcaatg taaaacaaga aagagaaaag ttccctatca tatctgggtt 2498461 gcttttctct ttcacgtact tattgattca tatcccgtat ccattcatac attgactggg 2498521 cagtattggt tacggtgtcc gaaagcgctt ttccggcttt tgaaaacata ttgaatgtct 2498581 ccaccttttc cagctctttt tgtttttcta ctaaatcttt tgccgtgact gtttctccta 2498641 ggattgaggc ttctttttca ttatcttttc cgtcggtgag cgtaaacgcc cccttcagtg 2498701 aagggtcatg atagcctttc atactcagca tcccgtggtt tgcctgctgc atgccgaaca 2498761 gaacgcctaa aaacatgatc gtgacaagca gtaagcactt tccaaagtat gcaatcaaat 2498821 caaccaccta tttcttattg ttttttcgtc tccccgctcg ctgcgttgac cttttcagca 2498881 tcccagtaca tttcgctgaa tacgtccgcg gccgcgttag ccgcacgctg cagctcttcg 2498941 agattattat ccactccgcc aaactcgagc aaaagcgctc tatcggttaa atcctgattg 2499001 taaacaccat tatcgcctgg cgagcctttg gaaaagacac ctgtgctaag tccggggtat 2499061 tttttctcca tcagtttatg aagctcactc gcaattttat agttttcttc gaagtttttg 2499121 ctttttttcc cgacgacaaa ggctaccctg gcatagcttt tccctttaat cgttgcggtt 2499181 gtgtcttttt tgcgccgaga gtctctgtgg atgtcaatga tatattgcag atttttgttt 2499241 gaagcgaggg cgtctttcac gaccggcctt gattcatcat aggacctggc atagtttaag 2499301 ccttttttat tcaattttga ctgtatatcg gttttattca ctgtggctcc gattccctgg 2499361 gattcaagcg cttgtccgaa catatctcct acaagcgtga cattggcttt agaatggcgc 2499421 gccatgtcag gatcggtctc gccttttaat agagggagat atgattccgt attgtgcgtg 2499481 tgatagataa acacgacctt tttatcacct gttgtttgtt tcggcggatc tttttgcgca 2499541 ttatctgatt gcgtttgctg tttttcaatc tctgccaaat tcgcttctct ttcttcctcc 2499601 atcaccttag acggcggcgg cgattccgca ggcatattcg tataatccgt tccttgtcca 2499661 gctaacaaaa tctcggtatc aaattgtgca aatcctggca gctcccgacc gagaaagctc 2499721 cgcggatctt cgaggttaat gctcgtcgcc agctttaaag aaagacgaga aagatgaaat 2499781 gagctgtctg tttgagagag gtcagaagcg aaataatggt tttccatctg cagcaaatgt 2499841 gcaaatacgt cacccggcaa ttcttcagca atcccataaa aagagtcaga cgacggccta 2499901 agttccggcc ggagagacgt cagcacaccg gatagaacaa aaatcacgat aaggcttacg 2499961 ataaatagaa agatggcttt taccgctttc cctccattta ccgcaacaac aatctgtctg 2500021 tttctgcgtt tatttctcat tgaatccctc cagcgcttgt ctagtaatta ctctatgaac 2500081 aagctagagg aagtagaact gtttagtgat tgtaggagcc tttgttttct tgtgacactt 2500141 tttcatgaag cgctgtgttt aatccgttcg ctaaaacatt tgccatatcg tcgataaatg 2500201 aatcgacttc cttcggtgta accattaagt tgtgccctaa aggcgaaagc acctcgtgaa 2500261 tgagctgccg tttttcatct tcttgaaggg ttccgacaat acctaggaac gattggcgct 2500321 gcttttgatc gggaagatcg tcttcagtga gcactttctt tttcccaaac gtcatgcctg 2500381 ccggaacaag cgatcttgat ggcctgttat ccttcatttc tctgccaaaa tgttttaata 2500441 tgtagtccac cgtgtcgctg gcaattgtca cggcatcaac tactgtcgga acaccgatag 2500501 caatcaccgg aacaccaagc gtgtctttgc ttaaatcttt tcgtttattc cccactccag 2500561 accccgggtg aatgcctgta tccgatattt gaatggttgt gttgaccctt tccaccgccc 2500621 gcgccgccaa cgcatcaatg gcgatgacaa aatcaggctt cgattgctca atcacacctt 2500681 taataatgtc acttgtttcg attcctgtta tccccattac acccggtgca aaagcactga 2500741 caggcctgta accctcctgt acgttttccg gctgaagctt aaacaagtgc cttgttacca 2500801 acagattttc tactgccatc ggtccaagcg catcaggtgt cacgttccag ttgccgagcc 2500861 caacgatcaa acagctcgca tcttttgaga tattaaggtt ttcaagaaaa gctgagaatt 2500921 cctccgcaaa gacagcagag accttctcct gcatttccga atcattctcc ctgattccct 2500981 gtgcttcaag cgttaaatag cgcccttctt tttttcccga aagctctgcg ccttcctttg 2501041 taacatcaac tgtgcggatt ttaatgccgc cgtgatcacg ctctttttca ataaagcctt 2501101 taatttcttt tgtcggcaca gcctgctgat tggccattgc ttccttcgtt tccactgcca 2501161 aatcggtccg tatcaaatac tgattcacat ccagctcact ctttttcata caggggcctc 2501221 cttcacatta agtacctata ttgttgccat ttgctgaata aatcatgcta aaaagagaac 2501281 cttcaatgaa aaatacttta catttatatt gcaatctaaa ggtgtgtttg atagaataca 2501341 atttgttcta ttgtgaagaa gatttaacct taagacactg tgctacaggt tgtatcttag 2501401 gaggtgaaac acatgccaaa cattaaatca gcgattaaac gtacaaaaac aaacaacgaa 2501461 cgccgcgttc ataacgcgac aatcaaatct gctatgcgta ctgcaatcaa acaagttgaa 2501521 gcttctgttg ccaacaacga agctgacaaa gcgaaaactg ctcttactga agcagctaaa 2501581 cgtattgata aagcagtgaa aacaggtctt gtacacaaaa ataccgcagc tcgatacaaa 2501641 tcaagactag cgaaaaaagt gaacggactt tctgcataat ataaaaacga tcctcaataa 2501701 tggggatcgt ttttttcatt tctttttaac agctgtaaaa ggaacagttc gagcaggagc 2501761 tgcttgtcct ttttcccggt tttcatctca tagtccatga cggcaagctg ttcaataatt 2501821 aaacggagct cctcctctga aaaaagcctt gcttgatcca tcgccagctt tacccgaaat 2501881 gggtgaactt ttagattaga agcgatttgt ttttgtccgt atccctgttc cgcgaagtac 2501941 ttcgtctgca gaatcagccg gaactgattc gaaataagcg ccataatttt gatcggttct 2502001 tcattttgtt ttagcaaatc ataaaaaatt tgcagactct ctgttcgttt tcggttgacg 2502061 attttattga tcagctcaaa aatattttgt tcaaggcttc tagcaacaag catttttaca 2502121 tcatccagcg taatttcttc acgatctcca ataaacgtgc agagcttttg aatctcctga 2502181 aaaatcgatg acagatgacc gttcacaagc agaaccaaat gctccgccgc ttccgtgccg 2502241 attgttttct gctctgtttt tgcaaggttg acagtaaagt ctgtcgtttc ctttgcattt 2502301 aattccttcg cctccatcat aaacgcgtgc ttctttaacg ctttcgtcag cttttttcgc 2502361 tcatcaagct tttcatacgg agcaagcagg acaaagactg tgtaaggcgc aggtgattgt 2502421 atatatgatt caagcgcact gacgttgtgc tcaatttttt cttttttctt ttcacctgtt 2502481 aaaaaatatg gatttttcac aatgacaaga cgccgctccc ccataaacgg aaacgtttca 2502541 gcatctgcaa tcgcttgatc cagcgggtcc tcttccagat caaaaacgga cagattgaaa 2502601 tcctttgtct cctgatcaac gaccgtctgt ctgatcctgc tgacggtttc ttgcagcaga 2502661 tatgtctctt ttccgtataa acaataaacc ggatggacct ctcctttttt caggcttttc 2502721 cacacatcaa ataccattgt tgtacgactt cctctctttc atcatcccct tctatcctaa 2502781 attgagtttg caaaatagta aagaggaagc ctgactgctg cttccccatt tatattaaac 2502841 gcctgttcgc aagcccccgg gacagcttgt aaaaaggcga taatcaccag aacagaaaac 2502901 gttaccttag cttctagatt tttcaaaaca attccattat acttaagtca gtcaggaggg 2502961 ataaagttga atgattttga aaaaaacgtt caaagcaaac gaaatgatgc tgtagattca 2503021 gctgttggtt ttgttgtgtc cttcggattt ttcgccttct tgtttgtcat ggcaacggtt 2503081 attcacctag ttggttcata acagcgactg cccgggctgc tgatttctcg gcagtctttt 2503141 ttagttcgtc tctgttatat ctgatgtatc atatggagga tagacagaaa aggttccaac 2503201 tctgtttttg tatctatatt ggatcgttcc gttttgatct gttcgcagca cgcggataga 2503261 atgtctctgt aatagttgca gaactttttg atgaggatga tggtaccgat tgtttttccc 2503321 ggctgagata atggccgttt tcggctgaag ctgttggatg aattcttcac cggtagagcc 2503381 tttgctccca tggtgcccca cctttaacac atctgctttt atattcggaa acacgttcat 2503441 cacctcttgt tccccttctt tctccagatc acccgtcaag atccagctca taccgcccgt 2503501 ctccatccac agaacgagag atgaattatt tttgcttgcc ggatcaggtg cttccggtga 2503561 cagtacatgg aactgcaaat cctttatttg caacacatcg cctcgcttca cctcttcaat 2503621 tgccactccc tcttccctgg ctgcctgcag cactttctca tctttaggtt cagaaacgaa 2503681 ccctttcgga atcacgaggc gctttacttt atgatgcttc agcagaatct ccgcctctcc 2503741 gatatgatct tggtcagcgt gcgtcagaat taaagcgtca agctgcttga ttcccttagc 2503801 agttaaaaac ggaatcagca ccttttcccc cagtgaaaac ggatgctgtt tttcgcgcca 2503861 aggctctgac gagtaagaca aagtgccgcc ggtatcaatt aagacacgac cccgctgatg 2503921 cggagcacct acaaacatgc tgtcaccctg tccaatatct atcatatcca cttctccttc 2503981 ggaactaaga cacggatata taaagagcag aaacatcacc gtgcagcaaa tgcctccggt 2504041 taccatcaac tgcgacaagg agcgtttttc aatcgccata agcaatagga tgatcgtgac 2504101 tgtgaataaa aaaagcaaaa caggtgcagg atgtgcgatc ataatcgtga acacatcaac 2504161 atctgcaatg tttgtgatta acctattgat ccagcttatc aataaatcaa accagctgaa 2504221 aaacaatctc ccaaacgaag cggaaagact taatagaaga acacctgcta cagctcccgg 2504281 caaaatacag aaggtataaa atggtaccat caacatattc atcggtacgc tgatgataga 2504341 aaactgatga aaatgatata ggagaatcgg aagcgagccc agctgagcga tgagtgatac 2504401 aattgtcagc tgccccaagg aggttttaac ctgctgaaaa atagaagagg atagaattaa 2504461 agaaaaactg acggcgaacg atagctgaaa accggcttca aagagatgat aaggattgaa 2504521 gagcagaagg acgatgtacg aaaggcaaat tgcagttgca gagcggacac gccatttgac 2504581 aagacttcca gctaagtaaa cacccgacat gagagcggcg cgtagcactg aaggagcagc 2504641 gccggtcaac atcacataga gcggcagaaa taacagcaac agaattgacg ccttttctct 2504701 agttatacca aggcggatca tgatataaaa caaacctgct gtcaaaatcc ccacgtggag 2504761 tcctgatatt gccaagagat ggacaacacc aagcttttga tacgcggtaa gcacttcatc 2504821 ctccacgtaa aatctgtcac caactgtaag tgcctgtaca atccctgtcg aatcaggagg 2504881 cagaaggctg tttgtgaatg atatgatatg ttttctcaag ctgagcacct tgtacttgaa 2504941 attttcaggt tcgctgcagt tttggataga cgtgacagag tagttccaat gaatatgctg 2505001 ccgataaaga tactcgttat aatcaaatgc acccggcaca gttgcgtgat tcggttcttc 2505061 caatgtacca gtcaactcac atgacattcc tggttctatg tataacagct gttctttttc 2505121 accagcagac tgaatgcgat acgcagcagc ccatttttcc ttatcaggtg tctcaaccat 2505181 catagacata cggtcgccgt caattttggg aatagtgtca atcactgcct tgaattgata 2505241 ggttccctgc cgataggaag agacattctg agaatctgtg actgcataca gtacaaaaaa 2505301 caatataaaa gagaagaaac aaacaataat aagaaaagcg tgcctcgttt tgattaaaat 2505361 gatgaggaga aagaggatga aaagaaaaat agcggggaaa taagcggcgg cagtaattcc 2505421 agccgttgcc gaagctgccg ccataggcaa taataagcgc gaattacgca ttcatcacac 2505481 gtagctcgtg aaaagtgtat tcgcctgttc atgtatcttt ttcaattctt cctccgctaa 2505541 accggcatca gccaatttcc ctattagacc cgctacaaat gaaagctttt ctctgttttt 2505601 cagatcaacg atcatttcat cgagttcaac ctgttcaaca gttacacccg cctgttcaaa 2505661 taattcctgc gcatacggat gtgttttgta atcctcagca taataaaccg ttttgatacc 2505721 agcttgaata atagatttgc agcattgaat gcacggataa tgcgtcacat aaatctcggc 2505781 tccatcagtc ggcaccccaa acttagagca ttgaagaatc gcattcattt cagcgtgaat 2505841 ggttcttgcg caatgatcat ctatcattaa gcatccttca tctgcacaat gtacgccgcc 2505901 cgcgattgac ccattgtagc ctcctgctat catgcgtttg tctctgacta tagtagcgcc 2505961 gacagataat ctcggacatg tgctgcgcag cgccaataaa tggctttgag ccataaagta 2506021 ttgattccat gaaattcgtt ccacgttgtt ccctccaaat gttgtgttgc ctgaccttta 2506081 gtttacctat cataatgcat gaccgtcaaa tcactttact gtaatggaag actttatttt 2506141 ctcaaatgac ttttcaccta ttcctgaaac cttagtgata tcttcaattg tttggaaacg 2506201 accgttttcc tcccggtatg caataatagc ttcagctttg gatggcccca cccctgagat 2506261 gccttgtaac tcctctaagg ttgctgtatt gatattcacc agcgctccct tccctccatc 2506321 gctttggaca gaccctccgc caccttgctg cactgctgtt tcctctccct ttttcgggat 2506381 gtacaccact gtcccgtcct gcagaatctc cgccaaattt acttgcgctt cgtctgcttg 2506441 ttcactggtc ccgcccgctt tctcaattgc ctgagatact ctgtcccctg ttcgcatttc 2506501 ataaacgcca ggatgctgaa cagcaccttt gatgtctatc acaattgttt cgtttgactc 2506561 gtcgttgttt gcttcctgct ttaccactgt attttctgtc tctgttggta cagcttgctt 2506621 caccggctct ttatttttcc ctgtggccag aaagatcata atcgctgtga aaacagccgc 2506681 agaagccgct aaaataattg ctttcttatg ctgattcaac caattcatcg tgcatgttcc 2506741 ccgctttcgt catattttat tttcataaca catatggttt agaggataat agctcaaagg 2506801 aggggaaacc attgaagata ggctttatcg gcacaggaaa tatgggtacg atccttatcg 2506861 aatcatttat tgaatcaaaa gcggccgatc cctcaaacat gacaatcaca aaccgcacaa 2506921 ttgaaaaagc gttgcacata aaaaaccgct acaacagcat aaacgttacc gaaagtctcg 2506981 aaaagctcgt ttctgaaaac gagatgattt ttatttgtgt taagccgctt gatatatatc 2507041 ctttactggc aagagcgtta ccttatttaa gaaaagatca tattctcatt tcaattacaa 2507101 gccccgttca aaccgaacag ctcgaacaat atgtgccgtg tcaagtggcg cgagtgatcc 2507161 caagtattac gaacagagcg ctggcaggtg tttctctcgt cactttcggc acaagctgcg 2507221 gcgaatctgc aaaagcgaaa atcaatgagc tgatgcagca tatctctcat ccgctgcaaa 2507281 ttgaaagtga catcacgagg gttgcatcag acatcgtaag ctgcggcccc gcttttatga 2507341 gctatctgat tcagcggttt atagatgcag ctgtttcgga aacatcagtg tctaaacagg 2507401 acgcgatttt gatgtgtaag gaaatgcttg tcggaatggg aaaactgtta gaaaccgaat 2507461 tgtataccct gcctgcatta caggaaaagg tttgcgttaa aggcggtgta acaggagaag 2507521 gcattaaagc gctggaaagc ggtgtgcagg atatgtttca ccgggtattt caaaatactc 2507581 atatgaagta cgaggaggat atttccgcag tgaaaaagca gtttcatgtg tagacgagta 2507641 tgtcatacgt tcgtctgtac tgcaaaagca taaaaaagca ttttaaaaaa ccatcgtttt 2507701 aggaaacgat ggtttttgat ttctgcgcct tgaaaaagag gcgttctgat tgtgctgatg 2507761 gctcggtatc cgtaaaatca gctgtcacgc gatggagctg aaagccgcag ttcttaagca 2507821 tttcttcgta ttcttccacc gggaacgttc tttgctcgtg tgtctcatca aaacgatcat 2507881 acgcttctcc gttccacaca aaaaacgaca tatcatgaat gacagaaagc tcgtcacttc 2507941 cggcaaagct ctgccaaata tagctgatat cttcgtcctg gtcagcaaat gtgctatccg 2508001 gaaagacttc cgcaatttta aaagatgaat gaacatcaaa cagcaggatg ccttcaggct 2508061 ttaatacccg aaaaacactt ttaaaggttt cgatcacatc attttttgtt tttaaataat 2508121 ttaatgagtc acagcatatc acaacagcgt caaattgacc gtcaaagccg gtaatctctc 2508181 tcatatcctg ctgaagaaat aaaataggct ggctactcga taccttttgc tgggcgaaag 2508241 aaagcatctc ttcgctgaga tcgatgcctg taacctcgaa gcctttttcg gcaagccgga 2508301 tggagatttc ccccgtgccg catgccagat cgagaatacg gcctttttcc gggagagatg 2508361 cttcaatcca ttttgtccat tgatcgtaag gcgcgtgtga cattagctcg tcatacacgc 2508421 ttgcaaagcc ttgataaatc attgattcat tccaaagtca agatctgcga gcggagcgtc 2508481 tccccacagc ttttcaaggt tgtagtagct tctttcatcc ttgtggaaga catggacaac 2508541 tacatcgcct agatcaacga gaacccatct tgcttcatca aagccttcca tctttttgac 2508601 ttgaatgccg ttttcatcag cttgatcctt gatttcacgg gcaatcgcct gtacctgttt 2508661 atctgaattt ccgtggcaga tcagaaaata atcagcaacc agagaaatac cttccatatc 2508721 cagtgctaaa atatcctctg cccgtttatc atcgcaagcc gcagctgcga tctttaaaat 2508781 ggacttttgg ttcattcaca aattcctcct gttcagctgc cagacacaag ccagttatac 2508841 gttaaaaatg tgtctggaaa aaccggttga ttttttttca taagaaaaac cattgtattt 2508901 ttaatggact gaatcagcgc ttgattcaaa tctgtctcag caagcttacg cacctcatcg 2508961 acaccgggaa atgcccggtt tggctcaatg taatcggcaa cgtaaatgac tttttctaaa 2509021 agtgtcatgc cggggcggcc tgaggtatga tacctaatgg cgtcaagaat gtcttcatct 2509081 tgaacccctg cctctctttg gaccaaataa gcgccgaccg gagcgtgcca gagctccgga 2509141 ttatgatcca ataaatgcgc aggcattttt tcacgcgcaa taatttgttt catttcttct 2509201 ttcgggcgga atttggcgta atcatgaaag attgccgcta tttccgcttt tttagaatcg 2509261 gctccaaaac gctccgcaag ttcgatcgcc gtgttcatca cgccaaccgt atggatatat 2509321 cggtgttcgg tcaattgctg cttcacgcat gcaagtgcct cctcacgatt catataaacc 2509381 attctcctct acatacttct tcactttatc agggattaag tagtcagtgg gcttcttgct 2509441 tttaaaccgt tcccttatca tagttgatga tacctcaaat tccggaacgt ctgcaaagag 2509501 aagcggataa ggggtttcaa catgaaaacc ggggcgcttt actccaataa attgaatgag 2509561 gttcagcagc tcgtccagct tataccattt cggcaaatat tcaatcatat cagcgccgat 2509621 aataaagaac agctgatcat ttggataacg ctgcttcagt aaagaaacgg tatcaaaggt 2509681 atatgatggc ccttctcttt ccatttcaac aagctccagc ttaaaggacg gattagattg 2509741 aattgcaagc tttagcattt ccacgcgatg aaagctgtcg gtatagtctt cgttctgttt 2509801 atgcggcgga atttgattag gcataaacca aatttcatca agccccgcct ggtacagcac 2509861 ctcattcgcc attaagaggt gaccattatg cggagggtca aacgtgcctc cgaaaattcc 2509921 gattttcttc atttcaacca cctttaagga agctcgattt gtttattttc ctttgattcc 2509981 ttatataaca caatcgtatt gccgattgtc tgcaccaatt gagagcggct tccttttaca 2510041 agagcttccg ctacatcgtt tttatcctct tcgcaattct gaagcacgct gactttaatc 2510101 agctctctcg cttcaagcgc ctcagcaatt tgtttaatca tgttgtcgtt tactccgcct 2510161 ttacctactt gaaaaatcgg cgttaaatga tgcgcttttg aacgcaaaaa acgtttttgt 2510221 ttacctgtta acattctgtt cctcctaatt ttcctattac aatagatctc attttttcaa 2510281 tattaggctc ttgtccagtc cacaattgga aagacaatgc tgcctgttca acaaacatgc 2510341 ccacaccatc gagtgttttc aagccttttt ggcttgcttc ttttaaaagt gccgtctgta 2510401 ttggattata cacgatatca catacgacgg cactgctcgc ggcacgctgt aatgaaagcg 2510461 gcacatcgtc cacgttcgga tacatgccca cagacgttgt atggatgata acatcatact 2510521 gctcaagacg ttcttctgct tcttttatgc ttaatacttc tttattgtga aacgagggag 2510581 tagcttctgt aagccgcttt gctttttcta acgtccggtt gcaaatgtca aattttttcg 2510641 gggtatttcg gacaattgtt gtaaaaatgg ctctcgccgc tccgccagcg ccgatcatta 2510701 agaatgacag ttcagagatg ggcttgtcta ataccttcat taatgacttc acgaagcctt 2510761 ccccatcggt attgtatccg acaagcttat ctccctctct tctgaccgtg tttacggcac 2510821 cgagcacttt tgcactctca tcaatatgat ccaaataatc cataatggaa accttgtgcg 2510881 gaacagtcac attgattcct tgtacgccta gagctcttat tccttttacc gcatcctcca 2510941 gatcattctc ttctaccttg aaggcatgat aatgtccgtc aagcccgagg tctttcaatg 2511001 atgcgttatg aatatcaggt gacatagaat ggccaatagg atttccgata accccgtaca 2511061 gctttttcat acacctctcc ccttttctta aattaatgaa cgccgaacaa atacatgaac 2511121 gccttttggc gcgtatgcag ttaccttttt atcagcgtca tggacagtaa cccagcctaa 2511181 cccagagaaa acgatatctg tctttttgtc ttttatcgta aacgtatggg cgaccaattc 2511241 aggaaactca tccatttcat ctttacccgg aggtgtgagc aattcccctg catgcttttc 2511301 ataaagcgcg tctgcatttt caagttttgt tctatgaatc atcagctcat tcggcatata 2511361 gcaaataaaa ggagatcttt ccccagacac ataatcaaac cttgcaagtc cgccaaaata 2511421 cagtgtttgc tgatcattaa gctggaatgt gcgaggcttc agctcctttt taggagataa 2511481 tattttcagg tcctttttat tgacataatg cgccatttga tggttgttga taattcccgg 2511541 tgtatcataa agcgatgaac cgtcatccag cgggatttca atcgcatcaa gggttgtgcc 2511601 aggaaattgg gatgttgtaa taatatcttc ttcacctgac acttctttaa taatccggtt 2511661 aataaaggtt gactttccta catttgtaca tccgacaaca tagacgtctt ttccgttgcg 2511721 gtaatgctca atcgcgtcaa ttacttctct gattccctgg ccgcgacccg cactgaccaa 2511781 aaatacgtca accggtttta agccaagctc tttcgcttca cgcttcatcc attggatcag 2511841 acgctctctt ttcagtgact taggcaaaat atccgcttta ttgccaacta ataagatagg 2511901 gtttcccccc accaagcgct gcagcccatt aatccagctg ccgttaaaat caaaaatatc 2511961 aacaattttt acgaccagag agtccgtttc tccaataccg tgaagaatgt tcaaaaaatc 2512021 atcatcagtt aaggagacat cttgtatttc attatagttt ttcagtctga agcaacgctg 2512081 gcaaatcaca ttttctttcg taagcgatgc aggcggcgcg taccccaaac ctgttttgtc 2512141 ctcggtttgg atcgtaactc cgcacccgat acaaacaacc ttttccattt cttactcctc 2512201 ccactgaatg tgcccttttc gtttgagagc actcagtatt ctgcgttcga cctggcggtt 2512261 aaagcgcgta atgaatccgt cagaggaagc gactggcacg accaaaatcg tatggtagcc 2512321 gtttcggttt cccccgagta catcggtcag cagctggtct ccgatgacaa cgcagtcctc 2512381 ttttttcagc tccatattgc gcaccgctct attaaaggct ttacccatcg gttttcttgc 2512441 tttatagatg aatgggattc caagcggttc tgagaaaagt ttcactcttc tttcgttatt 2512501 attagagaca attgtcactt taatgccgtg ttccttcatt tcttcaaacc actcgatcaa 2512561 tcgcggcgtc gcgttcggcc tgtcccattc aacaagcgta ttatccaggt cagtaataat 2512621 tccttttaca tttcgttcct ttaatttctc aggtgtaata tgaaaaatat tttttacaaa 2512681 ctcgtcaggt aaaaaaaact tttttaacaa aacccgcacc cttccctttt tctttctttc 2512741 aaaatgattg tcgaaaaaaa tcgaacttgc gcctaaagaa aaactgagca aaaaaatttc 2512801 gacaaaaatt gggtttcttc accaggtgtg gataaattta cacacactat ccactcttat 2512861 tacatcactc tttagacaaa ttataaacac gatactcaca agttatccac tttttggtgt 2512921 ggataacaga acgattgttc ttatatgcat ttcatggtag attaaagata acttcaacct 2512981 cagatgaatg caacttatca ttgtatgcgt taaaatcatg aatgattcca acttttaagg 2513041 aggtgcctct cccattaatt gggttcctag catgagaaaa ctgtctgatg aattactaat 2513101 agaatcttat ttcaaagcca ccgaaatgaa tttaaaccgt gactttattg agttaattga 2513161 aaacgaaata aaaagaagat cgctcggaca tattatttcc gtatcttctt aataggaatt 2513221 tgtctatttt ttccgggcgt atttcctttt tttactcaga tgactgatat tatatcactt 2513281 tggctgcgcg ctttactact attttcagca aaaaacaccc ctaaaaagag gtgttttaaa 2513341 gggccggtta ttatgctaac cagtatatgc cgcccacaac aaggagaaca acaactaaaa 2513401 caacaataaa agcgtatcca tatgctctgc ctgcgccata catgtgaagc gcctccttaa 2513461 taaggtttta taacagccta tgtaggagaa ataaatcgga ctaggcggtt gtccggctca 2513521 acgctgcagg atctgcccat cttgtattcc ttcatatacg atccttgccc ctttaggtgt 2513581 catatgattt ccagaaggat ctataagacc agattggata agcgcttcat cagttgcttt 2513641 tccgccgtct gcttctataa aatgcttcca gttatctaca agagggacat ccaggcgctt 2513701 cgacacatct cttgtaatat cgttatatga gttgtgccat ttccttgctc cgccttttgg 2513761 ttcaaaagca gctgcttgat atctggaata gtaaaacaaa tgatgcttcc cattaccttc 2513821 tataattggg atacacgtca ttaagattgg cttgatcccg tgttttctgc tttcttcaat 2513881 aaaataaacc agattttctc taaaacgctg cttcgacact ctcggtttcc cctcagtcag 2513941 tatggcagcg tcattggttc cgaacataat aaacaaatac ttcggttttt gatccagcac 2514001 atctgtctga aatcggagac gggcatcctc tgtcgtctgt ccgccgattc ccgcattgag 2514061 tatatcaagg ttaccgcgct cagctgtttt taatatattg acccactgct gtgcttttgg 2514121 ataatcgcga taatcccaat tagagccacg cgtattactg tcaccaaatg ctacaacgtc 2514181 ttcgtatccc cttccctcgc atcctgctgt aacgaacagc agaaggaaaa ggatgataaa 2514241 atgtttcatc tttacacccc caaaagcctc actttaatgt tatacctctg tttctcttcg 2514301 ttcaatgaag agtttttcgc tatcactgtt ttttcctata gttaacgtgt ccccctcagt 2514361 gaatatcatt ctgctttcat tgcggcgcag ctgatgattt tttaaaattc ccttctttcc 2514421 aatctgaaaa acacacaaac caaagaaaag aaaataacct gaatccgcac tggaaacagg 2514481 ttatccgtta aatcctgcat ttactttaac ttcgatttaa gcttggcctt tgtttttggc 2514541 ccataaatcc cgtctgcagt taatccgttc atgagttgaa aacgcttgac ggcattcgct 2514601 gttttcggtc cgtaaactcc atctatgcca ttgtttttgg ctcccttatc agggtaaaag 2514661 tgaagtacag ctaaagcctt ttgcagctgg agaatgtttg tgccctttcg ataaggcgaa 2514721 gtgagcttta taaccccaga cggcagagga tatgatggtg aagtttcttt tggaggtgta 2514781 tccgaggaag aaattccgtt tagaaaagag ttccagtggt ccaagagttt ccgcggacat 2514841 tctttcccgg accacttttt gtggggaaca acacgattta acggaatatt gttttccttc 2514901 atcagctttc tgatcagcca ctgggcattt gatgttgctt tttcaaaatc gccgtcagca 2514961 ttttcacaga tttcaatccc gatcgatttg cggtttcctg tcccgtttgt accgtctccc 2515021 gcatgccagc cgttttcatc tatcgggaga tgctgataaa tgactgaatc gtcaactgta 2515081 aaatgccagc tttcggatgt gttcgggttt ttcacaaact tggcgtgcat tttcgcatca 2515141 gcgcctttgg ctgtattcgc tgtattatgc accgtaatat aagcaggcgc catcgcatag 2515201 ccaggacgat tatcatttga taccggtata aaatcctttt ttatggttac catttctatc 2515261 cctccctatt aataagaatg cagaaaacag agagatggac agcctttttt atgaggtaaa 2515321 aaagaattgt gttcttaacc tggttttcag ttgaacagct gaaatggcac cagttatact 2515381 aatttagatg acggaggttt tgactcctga catcacctaa gttgggagtg accatagaca 2515441 tgttaaaaaa agtaataggt atacttgtga ttatcgctat catttcagtt ggtttttttc 2515501 agaaagaagc ttggcttgat gcaatcaaag caggagggat gttttccgtt ttatttagta 2515561 tgctgctgat tgctgccgat gtttttttcc caatagtgcc gtttgctttg attgctgctt 2515621 taaatggcgc agtgttcggg actgcaaatg gaatttggat tacactgacc ggctcaatgc 2515681 ttggtacaat attgctgttt tttctcgcca ggtacagttt tagagattgg gccagaaaaa 2515741 aagttcaggc ctatcctgcc atacaaagct acgaggcttc cttcaacaaa aacgctttta 2515801 ccgctgtttt attaggaagg ctgatacctg tcataccttc acttgtaatg aacgtgatct 2515861 gcgggctgag ccaggttcgc tggcatgttt ttttctttgc gtctttaata gggaaaatcc 2515921 ccaatattgt tgttgtcact attgcaggtg ccaatttcac cagcaataaa ttattgtcta 2515981 tcagcattta cggtacatat attctgatca tcatgctggt catttataaa aagttccctc 2516041 atcttctgaa ggtgccaaaa aaataaggag gcttgttggc ccccttactt tttttctgtc 2516101 gcatggcctc caaattcatt tcgaagcgca gcaaccacct ttcctgtaaa cgtatcgtct 2516161 gttaaagaac ggtatctcat cattagtgac atggcgatga ccggcgttgc cgtctgcaga 2516221 tcaagcgcgg tttccaccgt ccattttcct tcacctgagg aatgcataat gcccttgatc 2516281 tgatccagtt tcgcatcctt agcgaaagct cgctcagtca gtcccataag ccaagaacga 2516341 atgacagaac catgattcca cactctggca accttctcgt agtcaaaatc aaattggctg 2516401 ttttcaagca cttcgaatcc ttcaccaatc gcggccatca ttccatactc aattccatta 2516461 tggatcattt ttaaaaaatg tccgcttccc gcttcaccag cgtatagata accattttcg 2516521 acggcagtat cacgaaaaag cggttccaca atctcccatg cttcatgatc gccccccacc 2516581 ataaaacagg ctccatgccg tgcgccttcc attccgcccg acgttccggc atcgagataa 2516641 tggatacccg cttctttcat ttgattgtag cggcgaattg attctttata atgagagttt 2516701 ccagcttcga taatcatatc gcctttactt aataaaggtg atacatcacg caaaacagca 2516761 tcgacaatgc catgcggtac cataacccat aggatgcgcg gcgggtgtaa taaagaaatg 2516821 aactctttaa gatttgttgt cccctcagcc ccgtatgctt tcagttcatc aacagccgct 2516881 tgatttacat catatccaac cacttgatga ttgcggtcaa tgaattgctt tcctatgttt 2516941 atgcccattt tccctaagcc gattaatccg attttcatat ctgttcctcc tgattgtcta 2517001 aaaagccttt actctttatg ttccctatgg attgtattgt gatacgcaga aaacaaatgg 2517061 ggcttacatc gtctgcgcat gtaaatttta tttttcatga ccgacggcgc ctgccagttc 2517121 tattactgaa tctctttata tccataatta tcgctttatc cttgatttac catcagttta 2517181 agttaaaata tgggaaggaa ttcgattttt tcagtaaaaa gaaggtgaca tgttgcagaa 2517241 tcaatctcat actcttattg gagttacgaa aaccgctgta ttctttttat acgctgcact 2517301 tgcaatcatc ggttttgcaa tcgggtattt tattccgcag attgcgaaat gggcattatc 2517361 cctcccctgg atccctcttg aaggaccact tcggctcatt acctcttttc agggatctac 2517421 agcttcattt atcactgctc ttctcggtat gtgtgcgggg atttggttcg ctcattctgt 2517481 tattgcaatg ctgctgtctg tcaaaattac agatcacaca gtggaattca tcaaaggaaa 2517541 aaaagtgcaa acaattcatt ccgatgacat cgctcttgta tttatggatc acaaacggct 2517601 tgtcctcctg ggaacagccg gatatgaatt ggtacgggaa gaaattgatg aaaaaccagt 2517661 aaacgttgag aaggccttta gacagcatca ttacgaatgg gcaacagatg gtgatccgtt 2517721 taaagatcaa tttcgccgat ggattcctga tgcaccagac ctatcgcaag gcgcccatgc 2517781 cttattaaaa gctcgtcaca aagcactgca ggacgaagaa aaagacgata ttgaagaatt 2517841 ccgtctcgaa ctggcacagc tgggcatcgt tgtacgggac gaaggcacac gccaatattg 2517901 gcgaaaagca gaaacctatc ccccgaaaat tcagctcggc gaaggattgt aacaacagag 2517961 gctcaagaaa gagcctcttc tttactactg cacaataaac agcactctgg taccgtcagg 2518021 atagctgctc atttgattcc ctacccacga gccggcgccg cgattatcag aaggcgtcac 2518081 atatcggaca tcagcccctg caccgccttc ctcgcagacc gccatcggcc actcatcccg 2518141 gtcatagccc ggcttggtcg ggattccctt taaagattcc tcccgccttt tgtctgctcc 2518201 atctctgtca atggtacaaa tatctggatg tccctctgca atcgcatccc taatatgact 2518261 gccggtttcc ggataacgag acagcggaaa atataacact ttgtcatacg aagatgcgcc 2518321 ttggatctgt tgcggaacca ttaaacaaag aagaactgct gcagcaagaa acaggcctgc 2518381 catccatttt ttcatcccca tccccccata cctttgttca tttcaatgta tgggcgcttg 2518441 atgaagaata tttttaacat ttgaagttag tatgctgctt accaaagccg gactcccccg 2518501 cgagaaattt cccggtacag acacagacag cctcccggtc acatacattt acatataggc 2518561 ttttgcctac atacttttgt ggaggtgacg atggtgacag gtgttttcgc agcgctcggc 2518621 tttgttgtta aagagcttgt ctttttagta tcttacgtga aaaacaatgc ctttccacaa 2518681 ccgctctcaa gcagcgaaga aaaaaaatac ttagagctca tggctaaagg ggatgaacat 2518741 gccagaaaca tgctgattga gcataatctt cgcttggtcg cccatattgt gaaaaagttc 2518801 gaaaatacag gtgaggatgc agaggactta atctccatcg gaacgatcgg gcttattaaa 2518861 ggaattgaaa gctattccgc tggaaaaggg acaaagctgg cgacgtatgc agcgaggtgt 2518921 attgaaaatg agattgtaat tacaaaaggg gggtgcatac acccctcttt aatacgtttc 2518981 aatatatatg gtgtcagaat ccacaatggt aacttctttc acgataaagt taacaattgt 2519041 ttttttatct tcaagagtta agttatctgc accgattgat tgaaaatagt cgatggctct 2519101 ttttagagca ttttcacttg agctcgtatc atctaggact ttcatttttg actggatttc 2519161 gttacacttt tcagtaagct gattttgctt tttttgcagt tcaataattt gtgctttgat 2519221 ttcatctatg tctaaatcat cgtcatcgct taggctgatt agcgttaaaa gacgcttgcg 2519281 gccttttttt gttttctcta tctctttttc aataagttct aattcatcag acaggtgatt 2519341 tgattgttca gcctctttaa aagaaacata cttttgagga tttgtgatga atttaaaaat 2519401 ttcaccccat acatgccggt tcaatttatt ctcagacatt tcttttccgc agccgcggtc 2519461 ctttgcgcca gaataatttt tccggcaagt atatacatag tagtctttac catgtgattt 2519521 tcttttcttc cctgtcatgg tatttccgca ttttccgcat ctaaccaaac ccgataacaa 2519581 gtaattgtga gggctgatac tcaagtgttt tcttttactt tgacctaaga gttcttgagc 2519641 ataatcccat tgttcagctg gaacaattgc tggaattgtc acagtgattt gttcttcttc 2519701 aggccttatt ttaattatag atttgttccc tgcctgcttt gaaacatagg aaccctctgt 2519761 atcatattta tactgtctat gttcaccctt ataggaagag ttcattaata tttgccgaac 2519821 aacctgcctg tgccatactt tggcgccttt ttttgtttta acccccatct gagttaaatg 2519881 tagagcaata ccatttactc tgccgaaaaa agggctttta tgatcggtga aatagttaaa 2519941 aatcatccga atgatttttg cttcctcttc taatatctca agagttcttt tctctttaac 2520001 aaatttatag ccatatagtt tagaatcttt aatgatcatg ccttttttca ttttttgaag 2520061 tcggccgctt gatgtccgtt ctttgatttt ggctttttca aattctgaga ttgccccgcg 2520121 cattgcgaaa aacaattgac cttctggaga attggcgtat tcaccattta caaaaatcaa 2520181 aggtatgttt cgctttcgca attcgtcatc aatgattagc tgattcatta atttccgaga 2520241 aagacggtca ggatcgtaac aaatgacttg acttataagt cccttgcttg catcctccct 2520301 caagcgattc aaagccggac gttctaaaag ctctcctgaa aatccttcat ctgcatactt 2520361 cagcacatct ttagtccctg ctttctttat acaggcctcg atttggctgt cgatgctcga 2520421 tcccttgatc gcttgttcct cggtcgatac ccttacatat attgctatca ccctgaatct 2520481 ccttcctata aagttttatt aaataatgat agcaatcgtt aatgcatttg tcagcttgcg 2520541 gtccctcgat gattatcact ttcataaaat gcatcacccc ttgggtaatg ctatgtaaca 2520601 gctgtttgtc caaatgagga gattttaaat taaactatag tgttattaaa cgtttcaatg 2520661 aatatgcaaa aaatttaaaa aaagttgttg tgacttttct acactccttt aggtcctcaa 2520721 tagaaaagat tttattttct atgcctcaac attcgcttat tatagttttc aatgatttat 2520781 tattatttga gagtacaatg gagtagtgtt tttcattgtt agatagttaa tgacatttca 2520841 ctggtgtcaa gttcgtatag ctagacatta ataaaaaaag gacacatata aatatgcatc 2520901 ctttaacaaa agagtttatt tatttccctg tttcagcaaa ttccttcaac ctattcccta 2520961 tttcatcacg aactctttgg aaaaacgccc atttttcttc ttctgtccct tgtgctcttg 2521021 ccggatcatc aaaaccccaa tgctcacgtt ttacatgtgg aggcgtcatc gggcatttat 2521081 cagcagcatc tccacaaagc gtaacaacta aatcagcatt gttcagaata tcagaatcga 2521141 ttatatctga cgtttgatta gagatatcta taccaacttc cttcatcgct ttaacagcat 2521201 tcggatttaa tccatgtgct tctatccccg cgctatacac tttccactca tcacctaaat 2521261 attgtttagc ccatccttca gccatttggc tccggcaaga gttccctgta cataaaaagt 2521321 aaatgatttt attctccata tattccacct ctacatcgag tgacttccaa agtattttcg 2521381 ttgaaaccat aaagcaacct taacaagtgc tatcatgact ggcacttcta caagcggacc 2521441 aattacggcg gcaaatgctg cacccgaatg aattcgatat caagcttcgc acttaaacac 2521501 agcggaattt ataatatatg cttggacagc cgtaaaagcc gaactgaaca atggtatgat 2521561 tttgctcatg aattttgcca tatatataga catgaaggcg ataaaaaaac aatgcctgca 2521621 acttggactg attatttgga ttggcagtcc aattatttta catatcactt ttgcattcca 2521681 acttgcatgt tgcgtaatat caaccttccg tacatacaat cacatgcaat tgaaaatgta 2521741 gcttggttat ttaaggtatc cccttcattc gctaagaaac gtttaagcat ttattacagg 2521801 aaactgactc aacatttatt tagtcaaact gttacgggaa atttatgccc cccctttttg 2521861 taatgaataa tgaaatcctc atgcatttgc gcgcattgaa aaaaacaaaa aaagacgtct 2521921 cccttcacga tccgatcggg caggataagg aagggaatga aataagcctg attgacgttt 2521981 tgaaatcaga aaacgaagac gtgatagata cgatccagct caatatggag cttgaaaaag 2522041 tgaaacaata cattgacatt ttagatgacc gtgagaagga agtgattgtc gggcggtttg 2522101 gacttgattt gaagaaggaa aaaacgcagc gagagattgc caaagaactc ggtatctcac 2522161 gcagctatgt atcgcggatt gaaaagcggg cgctgatgaa gatgtttcat gagttttatc 2522221 gggcagagaa ggaaaagcgg aagaaggcga aggggaaata atgcagaaga agccggatct 2522281 catactccgg ctttctctat ttgaaagagt tatgaaaatc atttttttca tcgctgataa 2522341 gctctccgag aaagacaggc aggatcgtaa caaataactt gacttataat cctcccgcag 2522401 gcattcaaag ccggacgttc taaaagctct cctgagaaaa tccttagatc ggtatacttc 2522461 agtacatctt tagtccctgc tttctttata caggcctcga tctggctgtc gatgctcgat 2522521 cccttgatcg cttgttccac gatatattgc tatcaccctg gatctcctgc ctataaagtt 2522581 ttattaaata atgatagcaa tcgttcatgc atttgtcagt ttgcagtccc tcgatgatta 2522641 ttaccttcat aaaatacatc accccttggg taatgctgcg taatacctgt ttgtcctaat 2522701 gaggtgattt tcaatgagta tgaaaacaaa taaaaaaacc gatggtttgt accatcgatc 2522761 tgttttctat atcactaggc cctcaatata gtaaatctag ctcattggtt atgaaagctt 2522821 attttcatta cacactatat attcatttgt tatcatttct atacgtttat atcaattatg 2522881 gtaaaaaatg gttacaaaaa cccaataaac gtccaaccta actttttcat cttatttatt 2522941 aagaatttta acctcttcct tgtgaaataa agaagcgatt ttcatctcca aacagttaat 2523001 gctatttcat cgggacatgt ctgttaaagt agccaataaa tacattcgga tatccactta 2523061 caaccacgat tcaatttgat ccactacaga tttctgagct gacattaaac agatagagtt 2523121 ataaaaatct gtaccagttc cctttcacaa ttaggacatt tcggcggcgt ttcggcataa 2523181 tgcgaactaa tttattaatg ttcaacaaca gaatttcgtc tattggcaat aaagaatcca 2523241 caaatcattg caagaatggc catcgcccac cagaacgttg agatcgcctg atcatgatcg 2523301 atgataatca aacgaatgac agctgtgatg ccaatataaa tgaagtagcg aagcggaaaa 2523361 tgaaagtctg atttgaagta tttgataatc aaagcaatga actcaaagta catgaagaat 2523421 ataagcagtt ctccaagcat ctcataatag ctgtccactt tgttgaacag tgacttgtat 2523481 acgaatagca caatgtacca agtctcgctg atcagaagtg cgcttaaggc taacgccaga 2523541 aagaacagac agacgttgag aagcgcttgt aacaggtaag gcaccttttt gaatttgtta 2523601 gaaaatctca tcatgttgtc tcctatttca atatattcgt ggtttttatt ctcagcctac 2523661 atcttggtgt tccaaaatcg tagcacaatg tagtacttag aattcttttg tatactgtga 2523721 aactgtccct gcatgcggga catcattcgc gcaatgcttc tttcaccgag tccgttgctt 2523781 tccggtgtta tatctgcaag tttaatcgta ttgctaacat ggatctcaaa tatctcttga 2523841 tccgatacaa acgtgatact gattttttct tccggatctg cgtatttcaa taagtttgac 2523901 atcacattat caaatacacg accaagctcc tccaaattca cgttaatata ggtttccggc 2523961 agctcgcctg aaatatggac ccgaaaatgc tcctgatgaa ggatagcaat ctgatctgat 2524021 attagatcgt agatcacttc tttcactgca acggtctcca gatcggcctc atattccttg 2524081 ttcagcagga aatacgcaaa cagattgtca gacaagcttt ttaattgcag tgctttacca 2524141 taagcattgg ctacataccg atctttgctg gcacccgctt cgcctccctc ttttttggca 2524201 aactccagat tcatgatcag cgacgtcagc ggtgtgcgca tatcgtgcga catttcggta 2524261 accaggctgc ggctctcagc ttgcaattcc tcgatagctt taagtttatc caggaaagct 2524321 ttccgcagat cctcaatgct ctttgcaatc atcgctaatt catcatgccc ttttatcgtc 2524381 atctcgtagt ccagttcgcc cccttcaaga atatgaatct cttgatgaat cgttttaagg 2524441 tagcgaagac tttggcgaat tccgaagaga acaatgatta aaaagatgag ggttgccccg 2524501 agcaaatcca atgcaaaggc cagatcataa tatcgggaag agtagaaacc gtcgataatg 2524561 actcgtcctt caccatcgct aaacttgaca ggatgtgaat gattttgagc gtactgagtc 2524621 agcttttcct ttccataatc cgattcggaa taaatagaat catattgcag ctcctgatcc 2524681 ttgaatatgg tgaggttaat gtaattttct tttttgaccc actcgccaaa cgcttttcta 2524741 tctgatgtag acaactcatt ttctgaaacg tacttgctga atttttgaat gtatcttgct 2524801 gactcctcgt gataatactc ttccgaactc agatatccct cgatcagatc atctgtgatc 2524861 ttttgcaacg tcagaaagat cacaccactc acaatcgcag caaccattat cagcaaagcc 2524921 agttttttgg ttagcgtaaa tttaagatgc gccaaatcga tatcctcttc cccattcagt 2524981 ttttatataa accggacgtg ccggatcatc ctcaattttg gagcgcagct tccgtatatg 2525041 caccatcacc gtattgttgg aacagtaaaa gtaaggctgt ccccacacac tctcatatat 2525101 attttgggca gaaaatattt tgttgcgttt gttcatcaga agtttcagga tacgatactc 2525161 cagatctgac aacttgattt gcttctcctc tttccacacc tcattaaatt cttcgctcac 2525221 tcttagtttg cccccgataa gaaatgtttc ttcctgttcc ttcttttcct gatagatagt 2525281 atatctgcgt aattgagcaa tcactctagc gtgaagttcc tcttccgaga atggtttagt 2525341 catataatca tcgccgccgg cgagtaatcc ctcagtttta tcgagtgtac tcgatctggc 2525401 cgtcagaaac agaatcggga cgttagagga tttcctgatg tgctgacatg tttcaattcc 2525461 cgaaatgcct ggcatcataa tatccaaaat aaccaaatca agcgagtcat tcacaagttg 2525521 caatgctcgc tttccatcct tggctcttag cacctcgtaa cctgcacgtg taagggattc 2525581 ctccaaaaga tcaccaatat cctcatcatc ctctacgact aatattcgat aggccatgtc 2525641 tctctcacct catgattctt gttgttattt ctcgtgtgtc cttactatat atcgttcata 2525701 gtaataagta cgttataaga tactacgtaa atcttaacaa tttatgaaag ctgatgctcg 2525761 ccacaaattt gtcacatttt ctaaaaaaaa tgatgactct tcataaattg ttaagattcg 2525821 gtctttatat ttatccattg taaggctcaa gtttttcaga tccgcactac acattgccgt 2525881 gataaatggg aaaggagtat tgatatgatt gtacaaaaag aaggacgcgg gcaaccggtg 2525941 agtctgcggg aacgggttca ttttctggac atcgtacgag gatttgcctt gcttggcatt 2526001 attattgtca attattttct gatcgtagat tcagtaaagg gattcgaaat ggcctccgat 2526061 gacgtactgc ataagctggt ttcctggttt gccgaaggga aattcgttac gttattctcc 2526121 ttcctgttcg gagtcgggtt tatgatcttt atggatcgag ccgcgcagaa ggtagagagt 2526181 cccaacaagc tgtttgcccg caggttatct atcctgttgg gatttggcat tttgcacatc 2526241 acatttgttt gggtcggtga catattggcc ttttacgccg taagtggctt cctgttactc 2526301 gccttctata aacgcacggc caaaacggtg cttagatgga ttatcgcact tatcgtgttt 2526361 caattcctga ctcctgtttt cacaatgttg tacaatgtca tcaatactgc agggtcaaaa 2526421 aacccgaatt tttcagagtt tactttgttt agccacagca gccttaccta catggaatcc 2526481 atcagcactc ggtggacaga tatggtcacg atggctgccg gctctttctc tatgatctat 2526541 tccatgtttc tcatgtttct gctgggcgtg tactttgtta agatggaatt tttcaaagac 2526601 atggaagcga aaaagcctat atggaagcgt atctggatca ttagcacaat cgcttttcta 2526661 ataacacaaa gcagtatatt actagacatg tttaatcttt ctgagaatat gctgtggaag 2526721 gacatttcct ctgtcttggg tcaaaatggc ggcttaaccg gaagtatgtt ttatatgagc 2526781 acttttgcaa tgctgtttct ataccttcct cagctgcgag gccctatgat gatattcacc 2526841 aaagtcggac ggatgtcatt gacctgttat ctgcttcact ctatcattgg aacagttctg 2526901 ttcctcaggt acggattcgg gcttgcggat catattcaat ccgccggcac gttcatgttc 2526961 agtctggccg tgtacttcgt tcttatgagc tttagtacat tgtggttgaa acggtttagg 2527021 tacggtccga tggaattagt atggcgcaag ctgacgtacg gcaaagtaaa cgggagtccc 2527081 aaagcaactc cgctgcattc ggaaaaatct attcagaaat aacccccttg cacagattgc 2527141 atgacttcaa attagtgttg ttgaatgaag cgggcattaa acggacagat ttgatatatg 2527201 gactagttat ttttatatca tttaggcttc tttgggctaa taaatccacc agagtttact 2527261 caatgtgcat tgctcatgat cgaatctaaa ttgaatcttt tacgcatgtt catagtcaaa 2527321 ggcgcctcat tcgactattt ttgtaacttt tcgcaggaaa aattcgagaa tgatgacaaa 2527381 tcccgcatac gacacttaat acggtagtga acaatagtaa attagggtta catgcagctt 2527441 gttttccaat gaaacaaaga aaaagaatca tacaaaaaga caggagaaag cttttgaagt 2527501 attttaacgc caaatttacc gcggaagaaa gagcgatgga atcacttttt tgtgaaaagg 2527561 cctcgcagag cagctcgaat gttttactga acgactgaac tctatatttt agcaactgag 2527621 ggagtgaaca atcatgaaaa ctaaaaatga accaaaagtt attctggaac tagcaaagga 2527681 atctgatctg ccagaattcc aaaaaaaatt acaagaagcc tttgcgatcg ccgtgattga 2527741 aacgttcggt gattgcgaag atgggccgat tccatcggac aatgatgttc aggagtcttt 2527801 caatgctccc ggagcagtgg tatatcatat tcttcaggat ggtaagaatg tcggtggtgc 2527861 agtagtacgt atcaacagcc aaacaaatca taattcgcta gatttattct atgtatctcc 2527921 agaatatcac agccaaggga ttggtctttc tgcttggaaa gccattgaag cacagtatcc 2527981 ggatactgtg ctttgggaaa ccgtgacacc ttatttcgaa aagcgaaata tcaacttcta 2528041 tgtgaataag tgtggatttc atatcgtaga gttctacaat gaacatcact ctaatccgca 2528101 tatgcatcgc aatggacgtg aagatgacaa gcccctactg aatgatgatg actttttcag 2528161 atttgtaaag attatgaaaa aaaaggacta aacaattgaa cacggcgaga tgccgcagag 2528221 agttgctggt aactttttta tatttcatta tcagaggaag gtaataatga tgtttaaaag 2528281 gtgttttgat ccctgtctca taaacagggg tcaaaacacc tttgaatcat cggtttcttt 2528341 tctgacatat accacgccca ctagtccctc aacatagtaa aaacatatca tgagttacaa 2528401 aagcttttat tcaaagcata tgtttatttt atttatactt attttcatca tttttcagaa 2528461 ttctggacac aaatcgggta cctattagag gccaaggaac tctacatttc attaagaaat 2528521 acgtactcat tgccctgctt taattaattt taagccctcg cactatgccc ccccctgaat 2528581 taagtatttg atgtaacttt gaaattaagt ttatgaaaat ctgtcacaaa cccttatttc 2528641 ataacacatc atttgtttca gcttccctcg cgaataccgg attaatgctc ggctttaaga 2528701 tagtcaacca atctctccgc actgttctta acatcttctt ttgaaagatg aagtgtccca 2528761 tattgtgtaa acgcaggaag aaaacgcatt cctatatagt tagcagtgac ttgaaacggt 2528821 ctgataagct cgctgatcgt gatattatat tctccgcctg cttgataatc agattcctgt 2528881 gcgcctaagg agatagctaa gagtagttct tttccatgca atttagttcc tccagttcca 2528941 taagcccagc catgtgttaa cacatcatct tcccattgtt tgagtaacgc gggactgctg 2529001 taccaataca ttgggaactg aaaaacgata cgctcatgat ctaacaggag ctgctgctct 2529061 ttttctacat caatgataaa attagggtat tcaccgtaca ggtcatgaac cgtaatgtct 2529121 ttctcttgct ttaaacgatt catccaggtt ttgttgacaa cagacgtttc caaattagga 2529181 tgtataacga taactaatgt tttcattaga ctgattatcc tttctttgcc aattagttat 2529241 tattttttac gataatgaat tgattctaat tttaaaatag caactttatt tacacctatt 2529301 ttatcctttt tcatgaattc agggcaacta attgggcacc aaaatcaatg atgacttaag 2529361 acattgtttt gtagaaatcc gatatacaga ataatccatt atttagaaaa tttctacctt 2529421 ttccctcaat ccttaccaat ttaaactcat taaggagata ctttatcacc aactttaaat 2529481 aataatggaa taagtgctaa taaaataatt cctacaacca acgtagatat tattaactcc 2529541 ttccatacaa tcaaattctt taaaaacatt tgataaataa ctaatgagtt tactggaatg 2529601 ttaagcaata agcccgtaag aagtccaggt gcatactttt tcattacaac agttgcgata 2529661 agatgtggaa aaatagcgtt gataaccata gaacctagaa agccaatgaa aatccatttt 2529721 gcaatatctg attctggcat atataaaaaa ccaaatgcag ataaataagc caacatagtt 2529781 ataacaatga cagcaaaatg aaattcattt gaagttactg gcttttgaaa ctttgaagat 2529841 tgttgtgacc actcaggtaa ccaaatagct tcctcaatat tatgaagtgt aatagcaaaa 2529901 caaaaaaatg ctacgaaata aaccacctat catttcctcc tcggtgccac aaccaatatg 2529961 gtttggcaac attatattac atttgaggct gattggatat ggtgttaaaa gagagaagaa 2530021 tctgccttag tagttgcttc ttaattatat gtgcaataac gtgttgttac gtggcatgtc 2530081 atattcaaat ataataactc taaagcaaac aaagatacct atatagtttg gcatcctctt 2530141 ttttagttcg agtccctcta tttattttgg gcacaaaata gacataattt atattgactc 2530201 attataccca tcacatacca taccccttaa accaatcagg attaaaatgt tttaaaaaag 2530261 gtgatcaaag attaagttat ggtctctttt attttatgta tgctgtctta atgcaaaaca 2530321 acactggaca ccactaagtc aaatgcattt catggtacta tagtcaagac ttgtccaagt 2530381 caccattatc aaaatgaatt tcatcaaaca cttgaaacat ttattgaacg cggccaagtg 2530441 tcataacatt aataagaaac caacgagtga tgaatctttt aatctttcat tttacccgct 2530501 ggctcatatc aaaggagctc taaccaaatt ttaatagctg tcgcacctat taattgcgct 2530561 aaaacccatt gcaggaattt tgtatttact ttttgcccaa ctgatgcgcc aataggagaa 2530621 gctattaaac tagtaatcat aagaaccaga gctggtacaa aaagaacctg gcccgtgatt 2530681 acttttccaa ctgttgcgcc aatggatgaa agaaatgtaa tcgcaagaga tgaagcgact 2530741 gtgactctaa caggaatatt taaaatcgat aacataatgg ggactaggat aaaggcgccg 2530801 ccagctccta aaatacctga tacgccacca atgataaacg ctaaggaaga agccaaccat 2530861 ttattaaata tcacttcctt atcttcgcta tgttcttgtc ctttctgtcc ttttttaggt 2530921 ataaacatta aaataactgc tataatagcc agaattccgt atataaagtt aattcctttt 2530981 tcagatatat aatgagaaaa gtaactcccc aatacactcc ctaaaaggat gctgcttccc 2531041 atgtaaataa ttaatgtttt atttataaga ccactcttac gataagccca aacaccgccg 2531101 agtgtcgcaa aaaaaacttg aatagcccct atccctgaaa cttcatgggc agttaatgac 2531161 atcactccca ctaaagaagg aatgtacaat agcattggat aattaataac tgctccgcca 2531221 ataccaatca ttccggaaat aaaggcacca ataaacccta taatgaaaag agttgtgata 2531281 aaggcaatat ccattttatt tgcctccttt cataggaaaa gggtatcttt ctattcgata 2531341 ccctttcaca ttcattagcc tttttgaatc caaaatttca atatatcgcc ctcgtccgtt 2531401 tgctctaaaa ggtcatgtcc gcctgattta gaccaggctg taagatcatt tttggctccc 2531461 ttatctgttg catgcacttc taatatttga cctgattcca gttcattcat cgcttttttt 2531521 gttctgacaa ttggcattgg gcatgccaag ccttttgcgt ctaatacttt atctgatttc 2531581 atgttcttct ctcctctttt tagcagaaac ttgtgttacc gtattgcaca gcggtttggg 2531641 ccaatctcca tttcacgctg tttttcttca tctgggctga ttttccccat gtttgtttct 2531701 cgaatctctt ggtatgcatt tggttgcgga ggcaaatgat ctgttactag gtgtctaaat 2531761 tctgtttcat ccgcaatgtt caaaccatgg ttctcgctaa ataatgtact tagttgttta 2531821 ccaacacttc cattctcatt tagctcgtca atgatcataa agtgtgccgg taatacaatt 2531881 aaatcctttg ataacgcttt gtaacggcta taaagcgttt ttcttaaatc tcctacccaa 2531941 tcttctgcca taccggctaa gtctggtctg ccgattgaat caataaacaa gatatcacct 2532001 gaaagaagat actggtcatc gacaatgaaa gaagtggagc caatcgtgtg ccccggagaa 2532061 taaatcggtt gaattttaat cgttgtattt ccaataataa tgtcatttcc ttcttccaac 2532121 ggctgataat cgaattccac ttcttcagca tctttaggcg gtaaccagta ggttgctttt 2532181 gttttttcag caatgactct gccgcctgaa atatggtccg cgtgaagatg tgtatcaaat 2532241 acgtgagtaa tcgttgcacc cttccccttc gcaaaatcta taaagaaatt caccatacgt 2532301 gtcgcatcaa taattgctgc ttcaccattg gaaatgacca tgtatgacaa gcagccttta 2532361 ccgattcgaa caaactgata catctcaccg ccatctttta aatccccgac ttttaccggc 2532421 tctaaatgtt cgctccatgc tttcattcca cccttaaggt aggatacaga atgacctgct 2532481 tcagaaagca tttcggatac catgacggat gaaccttctt ttgcgcaaac gaccagcact 2532541 tctttatcag aaggaatttt ctccaagata tcttctacgc catctaaaag atcaaaataa 2532601 ggaacattca aatggtcaaa gtcatgccct tctatcttcc aatcactaaa atcattttca 2532661 ttacgcacat ccaaaataaa taaaggttct ttgttaaaga tttttttgtc acttcttttg 2532721 gggtcattgc ctttacggtc atgtttcaat acctcctata tcaaatcttt tagcgggact 2532781 aaaacgttaa ggatacatca gcatctttcg taaaaccaaa aaaggtaaca gccccgccta 2532841 cttcgattcc ttccataaaa tcatcttttg ttaaacccat aacgtccatc gttatttgac 2532901 aaccaaatca tgcaactccc atttcaatca gttaagaata gaaggcacat ttgcgttcct 2532961 acaaccttct gcgacatgct cttttccttg tcgcaatatt acagacttta taagcatcaa 2533021 acagaccgct atttgccgca ataatcgcta ctcttgtact catctgttca tcatgctttt 2533081 tatttattcg gttttacctg tccaatcccg catacccggg acaacattaa taaccttttt 2533141 aaaaccttgt tttttcatgg tgcgggccgc catttcactc cttcttcccg aatggcagat 2533201 aatataaatt tcatcatttt cgtttaattc gttagcgcgc ttttccactt caccaagagg 2533261 gatatgcaca actcctggga tatgagcttt ttcatattcc tctatctctc gaacatctaa 2533321 aatgttaaga gactcgtcac tatctacttt ctgtttgaaa gcttctaatg aaatctcagg 2533381 aattgaagat gcattttctg atgaatgctc tcctcctttt cgaagaaaat gacgaagtat 2533441 ttctccctct gcttcagtac ccagatattc atggcctgta ctttttgccc atgcttccag 2533501 atctgctgta gaacctttat ctgtcgcatg aatttccaat acttcaccag cttttaaatc 2533561 cttcattctc ttcttcgttt ttacgatagg cattggacac gccaaacctt tagcgtctag 2533621 tacaatagtt gctttcatca ttttttcctc cttttcttat ataggggtgg gggtatacaa 2533681 atatacaaaa agtttctcac tgtaagttaa caccatgtat tcataccccc ttttatattt 2533741 gtgatgtttt taaatccttg tttcttcaat atttttactt gcctttaaac ttctcattcc 2533801 gcttagcaat gagtaaatga gtaacattag ataaataagt tgacactgcc ttcctcagca 2533861 tctgccaaat aagctgctac accagcatag tcaatatcat ctaatagttc tttttcctgt 2533921 aaaccaagaa gatccattgt catcgtacaa gctacgagct ttaccccctg ttcttgagcc 2533981 atctcaatca actgaggtaa agtaagtaca ttatgctttt tcatcacatt tttaatcatt 2534041 ttagggccca tacctgcaaa gttcatttta gataaaccca tcttatcagc accacgaggc 2534101 atcatctttc caaacatttt ttcaagaaat ccttttttca ctggaatcag ctcttcttta 2534161 cgtaaagcgt taaatcccca aaaagtatgg aagatcgtca cttcatgatc gtaggcagct 2534221 gcaccatttg caataatata ggctgccatt gctttatcat aatccccgct aaataaaaca 2534281 attgttgtgc gttttgtttg ttctgtcatg tttattctcc taactaatta cccctgcggg 2534341 tatattaaag tcaaaaaatt ttttcgaaag atctgctttt attcaactct ttaaatacca 2534401 tagggggtat aatataacgc atataaaaat tcgtcaacct taggttgatg aatttttatc 2534461 ggctctttac caataagtcg actgcttctt ttactaaatt ttgtgtgtct tcgccttttt 2534521 ctaaactttc acgaacacaa tgttcaaggt ttgtgctcac aattaaaccc atcgctcgat 2534581 cgatcgcatt acgggaagct gctaattggg tcacaacctc tctacaatct tttccttgtt 2534641 ccatcatagt caatacacct ttaatttgtc cttcaatccg tcgtaagcgg tttttaatct 2534701 tttgatcata ctccatatat caatgaaatc ctttctttca tttattttta catttacatg 2534761 ttgccagttc ataactgttt acatggatac ctttgcgctt tagaaaacgc actcctaaat 2534821 ttaattccac ccggtcacga gctattatgt gtattttatc acgtggaatc tctaaataaa 2534881 aacgttttag atacgcatat gggatgttta aaataatatt atccgaaaaa ttggctacat 2534941 cgttataatg acgaatatct aatattgtga tgtccatagc ctctaattta tctttatgga 2535001 tacaagagat tccggttata ggataataac gtctatacgt tgcaatgata atcacaaaaa 2535061 taagcaggaa tgcaataact aaataattga tactatttac accaccttat taactctttg 2535121 tttattcaca aaacaataat atacccccat aggtatatag tcaagtgtga aagttacttt 2535181 ctttgagctg atagattcat ttcgatatcc gcggattgaa aaaatactta cattcgataa 2535241 tgccaattct gctaaaagga actcgaataa agcaataagc cgatttaatt ttaaatcggc 2535301 tttatttatc aattacttaa aattagcaca agacacgctg cttggatatt aaatggggtt 2535361 tcattagcat ggtactggtt ccccatgttt catgctggat gtgactttaa ttattctaga 2535421 attctccaga atatctgtgc taatcttccg cagccactgc atctgctttg gtttcatgaa 2535481 ctgtaccaaa tggatggtta ggaggagcat aaatggagta aagttttaat ggcgtatttc 2535541 ctgtattaat tacgttgtgc caagtgccgg cagggacaac aatggcagaa tcatcataga 2535601 catttctttg aaagttcaaa tgatctttgc tctttcccat tttgacgatc ccacgcccct 2535661 gctcaatccg taagaactgg tcaacgttag gatggatttc caaaccaatg tcttctccaa 2535721 taccaagact catcaaagta acttgaaaat gctttcctgt ccataaagca gtacggaacg 2535781 tattgttttg ttttgtggct ctattgatat ttacaacaaa tggttttggt ccataatcct 2535841 tcaaaagaag gtttctatct tcatatgaag agcgcaaatc ggcacctctg tgtactttct 2535901 ccatctcatt tggaatagtc caataaacag atcttccatc attatacatc ggcacagtca 2535961 cataataata acattgaggc gaaaaagggt tatagtacat tttttgatcc ccgcaattat 2536021 aaatttttgt gatagtatcc tatgcattta ttaagggagt gtgctaaatc aagaaaactc 2536081 atattaaaca caaaaatgaa tgttcgatca ccgtttgatt catggatgaa taatttatca 2536141 ccgaccttgt aatcgttttc tagatgttga atttcactag cctttgttaa caagacatcg 2536201 aatgacacct ttatatgatg gattatcaaa ggtcgacgat cctaaatggc ttttgaacat 2536261 ttacatagca caacaacaga gtatacggaa ttctgttgtt tgtcccccct atcccagctc 2536321 ttttagattt atctctttgg atgcgccttg atggccagtt tttcagcagc atagaattta 2536381 tcccctcctg aatcgttata gcatatttca acgccgatag acttgcggtt cccagtgccg 2536441 tttgtaccgt ctcctgtatg tgggctcgct tttagtaaac cagtttatat tctttttggg 2536501 cacacaacag aaacaatttt ccatatgaaa atctcgtaat tttacacctc tttaacttga 2536561 aggaggattt ttgcatatgt attttcatac ccgtcaacta ccatctcatc cagcatatat 2536621 tcctcatatg cattttcccc tatttgcatt ccatttcttt caatgaactc aatgattctc 2536681 cggtacgcct cttcagtatt tccgcctatt tcatatccaa ctgcatacag gccttttggc 2536741 cgtacatgat aatttatgtt ctctgcccca tcttttactt ttatataaaa gtaactgtaa 2536801 ttgtagaagt ctttttctaa gatttgttcc cgtgcaaaga ttccgcctat cggatatcct 2536861 tcatctaatt catattgctg aacttcatga atgagttctg aaatggctgc cacatatttt 2536921 cgttctggta agtttaatgt ttttcggctt aacatgaatg tttcttcatt taaatattca 2536981 aaagaaattg aggaaaaatc agtctcaagt gcttgttctg taagcgtcac ttttgtttgt 2537041 aagatcgttt gcaactgctt aagctcattt atttttttat caatctcaat agacttttct 2537101 tttagaacat gcaggatctt gtctggtgtt tttcctttta ttagacactt tatttctttt 2537161 aatggaaccc caagctcttt aaatagactg atgacttgaa aagtctcaaa ttgatgatag 2537221 gaataatatc tatacccatt ttcttttttt atttccggcg agaaaagacc aatctcatca 2537281 taatgaaata aagtttgttt ttttacacgg cagagcttcg aaaactcccc tgttgtgaaa 2537341 tacttcttaa catcttcgct cataaaaacc tccttgacta tacggtaacc atatacctta 2537401 tgatttgatt gtacttgaaa aaagcttcaa gcgaaaagga taggtaaaaa gggttcaatt 2537461 gagtaaaagg ggaattcaga tgaaaaaatc aataaatgag caaaaaacga tattcattat 2537521 actattaagc aacatcttcg tagcatttct tggtatcggt ttaatcattc cagttatgcc 2537581 ttcttttatg aaaatcatgc atttatccgg cagcacaatg ggttatcttg ttgcggcttt 2537641 tgccatttct cagttaatta cttcaccttt tgcaggtagg tgggttgacc gtttcgggag 2537701 aaaaaaaatg attattctcg ggttgcttat attcagttta tctgagttga ttttcggatt 2537761 agggacccat gtttcaatat tttatttctc gaggatattg ggtggtgtaa gtgcggcttt 2537821 tatcatgccc gcggtaacag catatgtagc tgatattaca accctaaagg aaaggtcaaa 2537881 ggctatgggg tatgtttctg ctgcaattag caccggcttt attattggac ctggtgcggg 2537941 aggatttatt gccggctttg gtatccgcat gccgtttttc ttcgcctccg ccatcgcgtt 2538001 aatagcagct gtcacttccg tttttatact aaaagagtca ttgtcgatag aagaacgcca 2538061 tcaactctca tctcatacaa aggaatcaaa tttcattaaa gacttgaaga gatccattca 2538121 tcctgtctat ttcattgcat ttattatcgt ctttgtaatg gcttttggtt tatcagctta 2538181 tgaaacggta ttcagcttgt tttctgatca taaatttggc ttcacaccaa aagatattgc 2538241 agccattatt acgattagtt ccattgttgc ggtagttatt caagttttac tattcgggaa 2538301 attggtcaac aaacttggag agaaaagaat gattcagctg tgcttaataa ccggtgcgat 2538361 cttggctttc gtgtctactg ttatgtcagg atttttaact gttttgcttg taacttgttt 2538421 tatttttctg gcgttcgatt tgctacgtcc ggccttaacc gctcatttat ccaatatggc 2538481 cggtaaccag cagggtttcg tagcaggcat gaactccaca tacaccagcc tgggaaatat 2538541 atttggacct gctctaggcg gtatactatt tgatcttaac attcattatc ctttcctttt 2538601 tgcaggtttc gttatgattg tcggccttgg tcttacaatg gtttggaaag aaaaaaagaa 2538661 tgatgctgca gctttgaatt aattcatttt ctataaagtt aagtcatttg gatgcaggga 2538721 atgcccctgg ttaggcacaa taagaaaagg tacttaattt gataggctac atgttgcttg 2538781 acgtgaatat agtataagct gagttttagc aatatcagga taccgggata agaaaaaagg 2538841 agaatgtagt atgagtataa acataaaagc agtaactgat gataatcgtg ctgcaattct 2538901 tgatctacat gtcagccaga atcaattatc atatattgaa tctacaaaag tatgtttaga 2538961 agatgcaaaa gaatgtcact attataaacc tgtcgggctt tactatgaag gagatctagt 2539021 cggttttgca atgtatggat tgtttcccga gtatgatgaa gataataaaa acggacgagt 2539081 ctggcttgac cgatttttta ttgacgaacg ctatcaggga aaaggattag ggaagaaaat 2539141 gcttaaagcc ctcattcagc accttgctga gttatataaa tgcaagagaa tttatttaag 2539201 tatatttgaa aataatattc atgctatacg cctttatcaa aggtttggtt ttcaatttaa 2539261 tggtgaactc gactttaatg gtgagaaggt aatggtaaaa gagctataga tatccaagcc 2539321 tccttgtttg ctgagaaacg tttgaacttc gataatgatt acctacttaa actgcaagat 2539381 cattgtttaa aaaagcctgg atgaaaattt catctcaggc tttaagcatc ttattagtca 2539441 aaatctcatg tgttttatcc agatgttatt cttttttccg gacaatttct aaataattaa 2539501 tatgccggcc aactgtttcg tgcactttaa aaatataccc atcggcttct ataacggacc 2539561 caactgcagc gtctatttgt tgagtcataa accagccgcc tattgtatcc acttcgtcac 2539621 ttgctaacgt cgttcccaat aaatcattta catcttcaat gagcactttc gaatctaaga 2539681 tatagtgatt atcatttact tttctaatat taggcacttc atctttatca aattcatctc 2539741 tgatttcccc gacaatttct tcaagaatat cttcagcagt gactaaacct gaagtgccgc 2539801 catattcatc cacaagaata gcgatatgtg ttcgctcttt ttgcattttt accaatacat 2539861 catgaattgg aacggattca ataacatgga taacagggtt gatatgattt tctaacttga 2539921 aatcctcttt tatcttctgg tctgtgtcaa tataagctga caaaaattct ttagcattga 2539981 taaaaccaat gattgaatct ttatctccat ttaggactgg gtaccttgta tagctctctg 2540041 tcttaatgat cttaacaata gtttcataag aatcctcact agaaatcgct acgatctctc 2540101 ttctcggaat cataatttct ttggcgattc tttcatcaaa ttcaaaaata ttatttacat 2540161 atttcaactc attttgattg atttcaccgc tcttatagct ttcagacagt aagatgcgca 2540221 gttcttcttc agaatgagca agttcatgtt ctgatgcagg tttcaaaccg aagagtccta 2540281 ctataaaccg ggctgaacca tttaaaaacc atataaaagg gaacaggatg cggtaaaacc 2540341 aaataattgg ctttgcagtc aaaagagtga tggtttccgc tttttggata gcgagtgttt 2540401 taggagcaag ctctccaact acaacgtgca aaaaagtcgc catcacaaaa gcaatcacta 2540461 agatcaatac atgtgagact gtttcactta catgaaaatg agcaaataag gggtgcaaaa 2540521 tcacttcaaa agtcgattct ccgacccagc caattcccaa cgctgtaacc gtgatcccta 2540581 attgacaagc tgacaaatat tcgtccaaat gagtaatgac ctttttggct gatatggcac 2540641 ctttttttcc ctctaatatg agttggtcaa tttttgatga cctgatcttt actatcgcaa 2540701 attcagtcgc aacaaaaaat gctgttaaga caattaaaag agtaaagatt ataaggttaa 2540761 tggttgtcaa tgatttgcct tacctagtaa ggcgtacacc tccgatgtaa atatttattg 2540821 aataaacaaa aaacagtata tataacatta taagttcaaa agaacctaaa atcaactctg 2540881 aatgatgtaa ataatcatct ttttccgtat ggagagtggt tcccatagtc ttcaactaac 2540941 gattagtggc gttttaaggc ttaaaaaaga aagcaaaata aaaacacacc tgaattttct 2541001 ggtgtgtttc aataataccc aaccgtcttg atttatttaa tgtctttata aagattttct 2541061 tttaaaattt gaatcaattc ggcctgttgc tttatatttt tgcggccatt tctattaatt 2541121 gcagcaagtt cacagacaat tccagctgaa atgaaaaaca ataaaccttc aaacatttta 2541181 aatcccccac tgtctaagtg atagtcaaat ttgttttttc tttttgcaat acctgcttat 2541241 aatcttcctt acgctgatat atgttattta aaatgagtcc aataatgaca aacagtgttc 2541301 ctactatatc aaaagcagtt atgttatatc ctttgatcac catgattaac aatgtagtaa 2541361 tggggacaaa gttaataaat aaaatcccat taatggatga taggatttta atgccatagt 2541421 tccaactaag gagggctatg atacctggta aagtaatcat aaataaaaaa tcatacttaa 2541481 ttgctgcaat cactttaata ctcggtaccg acacgtaacc ttgcgcggta agtatagctg 2541541 tcatgattcc tgttatagct gtgccgaata aacatgtcaa agttgaataa cgaagtgtgg 2541601 accactctcg gaatatctgt ccccccattg tgtagacaac ccaccctaaa acaccaatga 2541661 atataaagag tatcgagaat agatgatccc ctaatgaaaa aaagaaactt atattacctt 2541721 tggttatgac catcgaagcc cccaaaaagg caatcaatat actgatcatt gtgtattttt 2541781 taggtttcac atgtttatat ccccatagaa taacaattga aagcatcggc atgagtgcct 2541841 cggcaatgga tgctgtcata attccagact tccccatcaa cctttgacct aaaaaaataa 2541901 gaacattgta tatagtaaac gccatcaccc caaataaaat gatccatttt gctttaccct 2541961 ctaaatgaaa tgatttcttt ccttctctca ccaataataa aatcactaac ataatcgtta 2542021 ccacaccgta gcgaataaat gaaaaataaa acggatcaac aaattctaat gcatgatctg 2542081 caactggaaa catcgcgccc caagacatac ttgctactaa acatgtaagg gcaccaatga 2542141 ataattgacc ttttttcatt gaattcccct ccttttcttt aaaattacaa tgagaattat 2542201 aaaaagaagt aagcatcaag taaaatgaac aaaagtgatg aaaaacatca ttgataatga 2542261 tactttaatg aaggggggat cttcatggaa ctgcgagact tacaaatttt caaatgcgta 2542321 gcccatcaca agagtattac cggtgctgca aaagagttaa attatgtaca atctaatgta 2542381 actgcgcgga ttaagcaatt agagaatgag ctcaaaacac ctcttttcaa tcgccataaa 2542441 aaaggggttt cactaagccc agagggccga aaaatgattg aatacgttaa caaaattttg 2542501 aaagatgttg aagaactgga gcaagtcttt ctagatactg aaataccgtc tggaatatta 2542561 aaaatcggta cagtggaaac agtgaggata ctgccgacca tcatagcttc ctattataaa 2542621 aagtatccta atgtggattt atcattgcag gctggtctaa cagaggaact tattaaaaag 2542681 gtcatgaatc acgaattaga cggagctttt atttcaggcc ccttgaaaca ttctattctg 2542741 gaacagtatg atgtttatac tgaaaaactt actcttgtaa ccagtaacaa aacgtttaat 2542801 atagaggatt tttcaacgac tccgattctt gtttttaacc aggggtgcgg gtatcggtct 2542861 aggcttgaac aatggctcaa agatgaaggt gtgctcccaa acagaatgat ggaatttaac 2542921 atcctagaga caatcttaaa tagtgttgca cttggactcg gtataacagt ggtaccggaa 2542981 tctgctgtta tgcatctagc tgtacaaggt aaggtttatt gccacccatt gcctgagaaa 2543041 gacagctgta tctcaacaat ttttatacgc cataaagatg cgtacctgac aaattcaatg 2543101 cgcagcctcc taaagaccat tgttgaacat aaaaatatga gtatggctta aagtgatttt 2543161 tctctttcta tattctaact tcttaaataa aagagaaggc tcatctccac ttcgctaccc 2543221 ttattcacgc aaaaaataga gcagtaaaca tgtgagttac tgctctgctt cgtttattca 2543281 ccgttcattt gttttacaat gtattcagca tcatttccta cgccttgaag caacgctgaa 2543341 cctcgcttat gctgccaagg caaacctata aagtacaatc cttctacagg tgaaacacct 2543401 ctatgatgta tgattcgacc ttcttgatcc aaaacacctt ttatatttat ccaacataag 2543461 ggattcctga aaccagtagc ccaaataata ttgtttactt ctaatgtaga tgaatcttta 2543521 aaaatgattt cattttgctt tgcggcaatg actctttttt ttaagatgat ctccttctgt 2543581 tttattgcat gttttaattc atgcccaaat actggatcac ctttcttttg aatgaatttg 2543641 cctactattg atgtatgact tgcatgtaaa actcctagtt tatcaaacca ccaaaagatg 2543701 cttctttttc cgatcattaa agggaaataa acaagtttat tactacaagc taaatatgta 2543761 actctttctt tggataattc aacagctatt tgagcaccac tattcccacc accaactact 2543821 agtacatttc catatgccaa ttgttttgaa ttcttatatt gtgatgagtg tagttgatta 2543881 atattatcgg ataaatcctt tgatattgat ggaatattag gggtatgaaa aggccctgta 2543941 gcaatgacaa gattcttcgt ttgatattct tcccgatttg tttttattaa gaaataattc 2544001 tttattttta ggacacttat tacttctgtc cgtaattgga ttggaatttc aaatttttta 2544061 acatacttct ttagataagc aacaatttca ttttttgaag gaaatccatg tttttctcct 2544121 tcaagatgca ttccaggcaa agagctatac attcgagaag taaataaaac taatgagtca 2544181 taccgatctt tccagctctc ccccacctca tgacttttat ccaaaatgat aaacttttga 2544241 tcggactgct taagataata tcctattgag atccctgctt gaccagcccc gattactata 2544301 gtgtcgtaca cattatcacc ccgccaattt caaattgtca gtagacagaa tctgcaaaat 2544361 cctagttgat ctcctcacta taaagttaga taaaaaattt aatggtgatg gtggtcacgc 2544421 tgcttctcca ttttgggctg acaaaggatc gcattgtcgt ggttatgcgc ttcggtttcc 2544481 atttgaatgg ttacgtgcgt aatgccttta tgctcaagtt catgttcaat tttgcgtaaa 2544541 atattttcac tttctgaaat ggtcagttga tcgtcaacaa ctgcgtggca agaaagagca 2544601 ttcaatccgc ttgtgataga ccatatgtgt aaatcatgaa tgttttgaat tccctctgtc 2544661 ccttcaattg tacgaatgat atcagagaca tcgatatttt ctggagttcc ttccattaag 2544721 atgtgaatgg aatctttagt cacattgtaa ccgcttctta gaacaagaat agccacaatg 2544781 atactagcca atggatctgc ccagccccat ccaaagaaga tgataagtat ggcagctaaa 2544841 atggcaccta cagagccgag catatcgctt attacatgta aataagctcc tcttatattc 2544901 agattattct ttgtatctcc gccactcatc ataatccaag cgaccaatag attcacaact 2544961 aacccgatga tactaattgt aagcatgccg gttgttgcta cttttggtgg attagagaag 2545021 cgttcgattg cttcataaat gatataaaga gaaataagaa ttaaggcagc accgtttatc 2545081 acagctgcaa gaatctcaaa tcgtttatag ccgaatgtct tattgtgatt tgcctttttt 2545141 tcagctaatg taaaagcaat cagggcaacc attaatgaaa ttgaatcact cagcatatgg 2545201 cctgcatcag ataaaagcgc caggctattt gttaaaaatc cacctatagc ttctataatc 2545261 atataacctg taatcatgat aaaagagatc aataaaacct ttttatttgc tccttcatta 2545321 tgattgtgac ccataaaaaa ctcctcctta cctaaagttt ttaatacata tgtatttatt 2545381 atttcaaatc tgttatgaag cattctaaca tgatacaaat aatatttata tatgagcatg 2545441 tgttcatata taaatatatc tgctctttac tgaaatgtca aaatattttt atagaaatcc 2545501 acaatacctc cttaattatt cttttataaa cataaaaaag cggagcaaac acatggtttg 2545561 ctccgctacc ctagtttctc tatccttttc ttcaatcaag catttgaggg tagtattcaa 2545621 ctacaattta cctgttaaaa attgggcctc accaagtcca aaactccagt cagcattatc 2545681 attttcaaca atagatacaa ttaaatcagt tgatgcgata ccacactcag attccagtct 2545741 ttcagctaac agcctgtaaa atttttgttt cttctcttcc ggtcgggatt tacttgtaac 2545801 tgaaagaaca acaagatttt tagttcggtt aaatcctaac ccagtatcct caataatcat 2545861 atgattttct ggatgttcat gaacaatttg ataacggtct tgttgaggca catcaaaagc 2545921 ctctactaca acattgtgag cgacatctaa aagttttttc aaacttgatt gatctcgccc 2545981 ttctattaag tcaaaacgaa gtaatggcat aaaatcccct ccttctacta caacagtctt 2546041 tttaatttca ttcgttaatg tgtcagctat ttccaagcag ctgctacatt tagaaaataa 2546101 agtaatttcc caataacccc ttcattctgg tgttagtcaa gcctatgtta tgatgtgtat 2546161 ttccataggc aatatacaga atcaacttcg agtaattaac cattttttga aatagcttta 2546221 tcacttactt tagaaatcat ttattcttct aagctttagt ttacatgaag ctctgctatc 2546281 atatataatt caaaattaag atggaagaca tctcaaaatc agatatcaac tatggaggac 2546341 tagatgaata ttcagttgtt acaggttttt ctcactactg ctcgtgaagg cagtatttcc 2546401 aaggctgctc tgactttaaa ttatgcacaa tcgaatgtaa cgaataagat acaacaacta 2546461 gaaaacgatt tacagacaaa attattctat cgtcatagtc gaggaatcac acttactccc 2546521 ccagggcaaa ttcttgtttc ttactcagag aaaattctac atactattga agaagctaga 2546581 gcagccatgg gcgaatcatc cgcgccttct gggccactgc gtataggatc aatggaaaca 2546641 acagctgcag tttggcttcc tcaactcctt gcacattata ataacctcta tccaaatgtt 2546701 gatttgaacc tagtaaccgg ccctacggaa caacaaatac aagcagtttt acattatgag 2546761 ttaaacggcg cttttatttc agggcctatt gaacaccctg atttagttca agaaaaggta 2546821 ttggatgaag agatggttct tgttacaagt gcttcacacc ctgtgatttc ttccattcag 2546881 gatgttcaaa cacaaacaat gcttgtattc cgtaaaggat gctcatacag agcaaagctc 2546941 aatcatatcc tgcaagaaga aggtttatta cctataaaat taatggaatt tggcatactt 2547001 gaagcgatca ttggctgtgt aagcgccggc ttggggattt cactgctgcc tcgttcaatc 2547061 attgcttcgc atgaaaaaga aggccgcatc cgcagccaca ctatctctga caaatattct 2547121 tttgtatcaa ctatgtttat aaggcggaaa gacactttaa ttacccctgc tttatctgct 2547181 tttttaacgc atatgaggga tcattttcag ataaagaggc cagatcaatc gtaaataaat 2547241 ggatggaagg catgcttcgc ctcaaaatac ccctgatcag ttgtctgata taaaaatata 2547301 ggcgcatctc aatgtttgta tagagcaaaa aagcaaactt cggtatgtag tttgcttttt 2547361 cttcgtgatt ttgcactctg aatcgtgaaa cctagtcgat attaggatgt agattttcct 2547421 cattcaaaga attttgaacg aaggtcattg ccctagacac ttggttgcgt cttgaagtta 2547481 aaggctgact atttcctaaa gcgtcaatcg ctctcacaac tattaaatat tcacctacag 2547541 atttcgggtg acaacgggaa gattgatatt ttcggttgga caggggcaga acatccaatt 2547601 gtaacagttg aagtatccac tgatggagga gatcctgcag atctgagtga tattgctgtt 2547661 gattgatcaa cttgtttttg ttcggaatat actcagtata tagccgcata ttcctcctgc 2547721 aatagctgga atgagccacc ccagccctat gttatacata ggaagaatct gagtgaaaat 2547781 acgattcaca acttcaattt ttattccagc cgccttcaaa ccgtcaaata ggctgatgat 2547841 gaatgcgaat aataaactgc cttgatacac ttctgtcttc cctttaaata cagaatgcaa 2547901 aaacgttaaa aatattaagg aaatcgcgat aggatacatc gtcagtaaga caggcattga 2547961 caccttaatg agctgggtta atcctatatt tgcgacaagc gtactaaaca ctgataaaac 2548021 gacagcaatt tttttataag aaatgttcgg aaataattca tgaaaaaatg aagaacacgc 2548081 tgtgatcagc ccgacacttg tcgtcagaca cgccactgta atcattaagc ccaataagat 2548141 tgaaccataa gatccaaaat aataggatga aaccttagcc aaaacctctg ctccattttc 2548201 taaaatcccc agttcttcaa cgctggaagc ccccatatag gaaagggctg tatacataac 2548261 tgctaagagt acagctgcaa tcgcggctgc ttttgcacaa acaactatca gctgtttttt 2548321 ggtagaagct ccttgttctt tcaatgcatt cacgatgata attccaaaaa caaatgctac 2548381 aagggcatcc agagtgaggt atccttcctg aaatccttta aaaaacgctt gtgatgtgta 2548441 cccttttgat ggtgcttgaa tggttccaat tgggcgaata agagctacgg ctacaagcaa 2548501 tccgataaat gtcagcttaa ttggcgtcaa aaatttacca actatatcaa tgatttttga 2548561 aggattgagt gataacaagc atgccaatgc gaaaaataat attgtaaata tgatcaatga 2548621 gacagggctt gcatcatttg ataaaaaagg ttttacccca atttcaaacg atacgtttcc 2548681 tgatctcggg atagcgaaaa aaggcccgat tgccaaatag agaatcgtcg taaatacaat 2548741 gccaaacacc gggtgaacac ggctggctaa cgactgtaag ttttgtttac ccgaaaaaac 2548801 aaatgctgtt atagccagta atggcaatcc aactccggtc actaagaaac ctgcattagc 2548861 gacccataca tttttcccgg ccaattgacc aagcataggc ggaaaaatga gatttcctgc 2548921 tccaaaaaac aatgcaaata gcattaatcc tataatgatg atataggaag cagacacttt 2548981 ttttgacatt atatatcctc cgattaaagt agacacttct tgaatagcca ggaaacatta 2549041 cagatgctat ttgcactggc acagtgttga ttccaaaata agcttgtgtc agttttatat 2549101 atttttatca agttaaataa aagcatgatc attttgatcg tttccgatat cggttaaaaa 2549161 accaattgca ccaaaaccat ataaacaacg gttccccccg ctatggaaag aagcatattt 2549221 ttcttccaca agtgaagcag tacaacagca gctgctccaa ccaattcagg aatgccatga 2549281 cttccagaaa gtagactcac atctttcaaa caataaatga ctaaaagccc gattaccgct 2549341 gatggcagca ctttaccaag atactgtaca tatttcggtg tcggtttgcc agacgggaaa 2549401 atcatgaatg gaaggaaccg tgtcagcatt gttccaagca cgaccattgc gatggtgatc 2549461 atttgctgcg tcatagtcat cgtcatacgg aaacctcagc tttctccaat ggttttctca 2549521 gaacagtcag tacccctaaa atggcgagca tagcaggaat aataaattgg tttccgccaa 2549581 aaaggataag actggctact gaaagtccaa gtcccgtgag agcactgtaa tgctttttct 2549641 ctttcatcca ttgttctatg aatatcacaa taaacagagc agtcatcaca aaatcaagcc 2549701 cttcggtatt aaacttcacg tacgacccaa aaatacctcc tatcgctgcc cccgcgaccc 2549761 aatataaatg attaagcagt gtcacaaaaa acataaacca gcccttatca acattcgccg 2549821 gaacattagc ggtataattg atagaaaatg attcatcgca cattccgaaa atcagataaa 2549881 gctttttctt tccagtcccc ctgtacttat ccaacatgga aattccataa aacaaatgcc 2549941 gggcattgac cattaacgtc aaaaaaagag cattcatagg gttgaacgca ccaagtaaaa 2550001 aattcgctgc aacaaactcc attgagcccg caaatatcat aaaactcatg atgattggat 2550061 agattgcgct aaatcccaaa gaatgcataa agatcccata agctatcccc aaaaataaaa 2550121 accccgcaaa aatcggaatg gtatatggga atgcagaacg aaatgcagcc catatttgac 2550181 ttctcttatt catatgagtg tttatagcag gagagcttaa atgtaacgat tctttatttt 2550241 tattcaaatc aacaacctcc tacatttcat caattggcac actgacagtt cttttttctg 2550301 tactcatgac tatgcttgtg tcaactccac taatagcagg gttctgcatt aatgaatcaa 2550361 tgataaaatt ccgataactc tccatgtcct tcgccacaat cttaagcata tagtcatggc 2550421 ttcctgtaag tgtgtagcat tcttgaacct gtgggaattt gtttatatcc tctaaaaatg 2550481 aatgaattgt ctccctattt aagggtgata agttgatgag agctagtgct gtgacttcga 2550541 ttccaagttt tttctcatca acaatagtcg taaacttttt aattatacct gcttctacta 2550601 ggttctttgt tcttgcaagg caagctgatg gtgaaagccc aattttctta gataaattta 2550661 aatttgatat tgaagcatct tcctgcaaat ctcttaagat ggccttatca gtttcgtcaa 2550721 gcataatacc catttcacaa cccccaatac aacttaacag aattatattt catacaattt 2550781 aaataataac gaatttttat tcgttaatca aatattattt aaatttaaat ccttttaaag 2550841 tattattcac agaataaaat tatcctcgcg attaactcat aatgaaatta acttacatca 2550901 gaaagaagtc atgggagagt tatgtacttg tgtgacttga taccaacatc ataagaaact 2550961 tatcagaagc caaaaagtta ttgcggtctc accgaaaatt gaatttgcgg tgccctattg 2551021 cctttttccg cgaacgaaaa ttgttaaaat tcgcaaaaca gaaagtctac tctattatta 2551081 ttttaaattc gtcctttagt tcttcttgag cctcttgtat aacttctaat acatcgtcag 2551141 cgtatgaacc taaaaatgta ttgctgaact caaaattttt caagactaaa gtgagcggca 2551201 aatccaccca ccctgtcagg caatcccata aagcgtctaa atttctccca tagtagtctg 2551261 ggaagtctag tttatctttt aaatcatcat gtaaaacttc tatattttca aagtctcttc 2551321 catctattat tatttttctc attagaaact atgccctcca ttattttatc ttaacaaacg 2551381 tttactatgt aacagctgtt tgtccaaatg aggctgaaaa caaataaaaa acaccgatag 2551441 gatgaaacta ttggtgtttg caagacatct tcatacccgg taggcataaa taatgctaaa 2551501 ctttgttttt aaaaagctat catatcaaat ttttatgtta cagcttttac tatcgtttaa 2551561 tctaattgag gagtaaaaca agatatgttt gaaaatcaca tatcccctaa aaattaaaaa 2551621 ctaatcggca gttcttcgag tgctctcatc agaaaattcc ctttccattt catttgtttc 2551681 ttttcgcctt ttaactgtat atttggacag cggcgtaata aggtggaaat cgcaatcttt 2551741 gcttctaagc gggctagctg tgcaccaaga caaaaatgat tgccatggcc aaaagcaata 2551801 tggcggttgt tctttctttc aatatcaaat atgtcggcat ttggaaatat cttttcatca 2551861 cggtttgctg atgctaaaga aatgatgatc acatctttcc gtttaatctc ctgcccatgc 2551921 agtataaacg gttcagccgt ccagcgaatt gtcgttagct caacagggct gtgaaaccgc 2551981 aatgcttctt ctatggctga attcatcaag tccggctgct ggcggagctt ttctagttga 2552041 tcatggtgac acatcagagc atatgtcata ttggtgatta agtttacggt tgtttcatga 2552101 cctgcaacga taagcagcat aatcatcgag tacaattctt ctgtacttaa ttgtgtgcct 2552161 tcactttccg cttgaattaa tgcactgatt aaatctcctg caggttctct cctttttttg 2552221 cgaactaagg attccagata ttcaacaaac tcccctaaca agtggtcatt ctcctgaagt 2552281 ctttcagggg catctgaaaa atcaataatt gcttgcgacc atactctgaa tttttgacga 2552341 tcttccaagg gaatgccgag catttcactt atcacgataa tcggcaatgg aaacgcataa 2552401 tcgtctacta ggttcatgaa tttgttgggc tgcactttat ccaataaaga atctgcgata 2552461 tgctggattt tgtcttccaa ctgcaaaatc atccgatgcg taaatgcttt ttgaacaaga 2552521 gttcgcaagc ggttgtgatc agggggatct gaattaagca tatgttttgt taaagtctct 2552581 tcattcttca atagagcagg acgtttttct tttgcggtaa atacattttc atagtttttc 2552641 tttaattttt cattctttaa taaatgtatt gcatcatcat atctcgatat gagccagcct 2552701 ttccccagag ctcctaaaga taatgggtag agagcctgtg attttcgcaa ttctttataa 2552761 aattcatacg cttcatcttt aaatgctctc gaagacaatt gactttccgt caaaatggtt 2552821 acactctttt tttcttttga agacattcat tcgacctcca tctttgaaag gttatgataa 2552881 tctttaaata taaaatcagg acgatttgta aaatgatcca ttgagatcag tattcatgat 2552941 aagggccaaa atgccgtccc cgcattttga aataaaagat atgagacagt cattaatcat 2553001 tttgctgcct aaactctttc cctgataaaa tggcgaaact cctaatactt ctatgccggc 2553061 tcttttaagg atttggaaaa ttttttagcc ccattttgat taatgttatc ccccctgctg 2553121 ctatataatc gatcaagttt aatgtcgggt ttatcacgat gttttaatag agcggcaaca 2553181 accatttcac cattctgaat gccaacaaaa aagaaatgct ttttaaaata tgctcttgtc 2553241 agtactttat gcatttcaaa aataaatgaa tgatcttttt ttcgcgtttt acgagtaaat 2553301 ccataaaagg atattgattg aaagattgat ggaatagctt tgccactttg cttacttcat 2553361 ctgctcttgc ttgtcgataa agaaacattg atgcacctcc tctgagcagt aaagcaggaa 2553421 atcgaattaa agcgcccttc ctattggaaa ggcgcctgcc gttttactgt gccaaaatgt 2553481 ttttcatcag tgagttttta taaaatcatt tattaattga tcagttgtca atattgtggc 2553541 aaattcatca tgcaatgtag ctagagatat attatgaata gtcgccgcat cataatatgt 2553601 atcattttgg tctctcattc cgaaggctgc tgttgcatct gaaatcaggt atgtatcaaa 2553661 ccctaaatta ccactcattc ttgtggtggt tgatacacag tgaggcgtgg ttaaaccagt 2553721 tatgactaca gtggttattt catttaattt taagaattct tctaaattcg taccaataaa 2553781 gctgctattt actgtcttgg ttataatgac ttcttcatcc ataggcttaa ctatttcctt 2553841 tattgcaaac ccttcattct ttggatggaa taaagaatga ggtttatcag aagtgtgttg 2553901 tatgtatatg actgtccatc ctttttctct ccataattct agtattttac taatgttttc 2553961 ttccgccttt acgttattcc gttcccccca ttttttatca tcgaaggctt tttgtacatc 2554021 cacaatgatt aaagctttct tttcttccac aagataccct cctacgtaga atttctattt 2554081 attactacat tctaaataca aattttactt ttgtacaatt gtttaatgat gaatttcaaa 2554141 tgagcgcctt ctttattgga aaatgcgttc tatactgcaa ctgtgcccaa gccgttaacc 2554201 ttcaaatcta atctgagaat cactggctct acagagaata ataaaaaaca ctctaataac 2554261 gagtgctgaa atgaaaaact attgatttag aagccatttg atacgctcag ctgaaatgat 2554321 gtagtggagt attataagac ataaaaagac aatactaact ggttttaaat aactaaaata 2554381 aagcgctgca acagccattg caaagatcaa taattcaata actaaccttg ttactccgtt 2554441 tacagctatt acagtttgtc cgcttcgact aggatcatga ggtactgcaa atacagacca 2554501 gacaatcata actgcaatag gtaaaaccaa agttaaaaca tatttaaaat aaccattaaa 2554561 gcttatccaa gcatacaccc ctaaggagat tagtgcagca atttcaaggg tgaatcttaa 2554621 aagtaaatta gtctgattca gtttttccaa ctcctctata aaaaacaccc ccgcaggaga 2554681 tgctctttct ctgctttatt tcagcgtata aaaacttttc tgttcttcct ctttagattc 2554741 tattgtagtt ttcggcgaga ttacctctac ttttgaagag atgataccga ctgctgctgt 2554801 taccaatgct ccgataatag aacgatgata agtataatga aatatgacaa cttttcccct 2554861 cctattcagt taattatcca aataatcagg aagttgtcta caatttgcag aatttgtcga 2554921 acgaagtaaa gattatacct gggaggcttt actcattgta tgaattacag taaataaatt 2554981 gccttccctt ttgagaagac gttccaactc agctagactc ttccaatagg cttccttttg 2555041 gcgcagctgc ttttattcaa aaattgagca acacctgaat gtttcattgg aatttctgaa 2555101 ccatcgatcg ctgctgaatt tgttgcaaat gcatacgtag gagtagtcga atggtggttg 2555161 aaaaatgaaa tgccttcccc acctcgagtg atggcagaaa aagcgggggt tttgttagag 2555221 aggaatctat agatatgtgt atcgaagatt tgacagcatt aaaaattata cttacatcgt 2555281 tgggaacagg ccaacaataa agcggaagaa cgttgtcatt tgaagtggtt tggaataaaa 2555341 atgattcgaa tatgttctta tcattgtaaa cgaacaaaaa aagaacatgt tttgaaaaaa 2555401 gattgatcaa aacatcttct tatatgttgt catagcgtaa ctttttataa aaaggttaat 2555461 tacattttcg gggcttccaa accaaatttt gcccattctt cttttgctgg accataaata 2555521 cctggaacag ttaaacctgc ttgtctcata agaacagtca tttgtccccg atggtggttt 2555581 tgatgttgaa ttaaaaacat caaaagtgaa ccgttaggca tttgttgtcc aataaagttg 2555641 atacgttctt gaagtgtatg gtcagtccat tgggttttta atgcctgtac aaatgcatta 2555701 ctggcttgat gatagctgtc agctataaac tgagcagaag ttggaacagg ataatcttca 2555761 gctggggctt ggaacgttaa gtctgtgttt gaggtaatga tgccaatggc agcaacagta 2555821 tgccaagcaa tacggcctag agtccaattt tgtgaagtta tttcttgttt aagtgattca 2555881 tcagtcagac tatttaatag tttctgtgta gcatctgctt cgaactccca agatttcaaa 2555941 aaatggtcta aggtttgaaa cacaaaaatc ctccttttca ttcttttgtt ttttcaatgt 2556001 gcttataggt taattataat gcctcctttc gttaaaaaga acaaaaattt cggacaagaa 2556061 taatcatagt aaaatgcgta gacattctta aacgtaacga tttacgcatc tttttacaaa 2556121 catctgacta cttggtctcc attgtcagcg agaatcaaat atcatatgaa gacaatccta 2556181 tattcttatc actttactga gcaataaata ccttccgtat acttagtaat accttcatcg 2556241 taatcaggat acttatatgc aagaccttct gatacagctt ttgaatactt tctaaataat 2556301 gcatagcaag taaataaaga cttccacatt tcctgatacc cattcacaga atatgtagac 2556361 atgagttcct cccattcttt atttgaaagg taccgcttca taaatttata gttcttcccc 2556421 atactaaatg aatacccttt ctgagatgcg atatgccagg ccatcattct caataaatta 2556481 ggacgtacaa tttcatttaa atggtcaatg gcaaaaagga tttcatttct tgctagtcct 2556541 tttactacgt aagtcgaaac catccagaac tcattacagc aatcatcaaa ttcccttgca 2556601 gtcggccttt ttatccagta ttggcgatca tttggggtca ctttatagtt gatgaacgaa 2556661 tccttatcaa gcaatacctt aaccaaacca tcgttattag caaaataatc ttctgcttca 2556721 cgaattggaa taagggttag atctaatttg ttgccatcct caaaaagaat aatgtatgaa 2556781 aaccaattac ctaattcggg aggaaaaagc tccatatctt ctggtttttg catcataatg 2556841 cgcttcccaa agatttcgag ccactgatca ttttctttaa aagattctac atcagttaca 2556901 aaatacgaga tgtcataatc ttggaagttg tcaggaggga tatttctgtt tgtacgtgac 2556961 ccttccaaag tgaccaatcg gattctctca tcgttcaaag caaagtccaa aaaaatgtcc 2557021 atcatttcct gctcacttcg cattacatgt tcctccgttt cagccttaat atctaactgt 2557081 aaaacgtctt atagattttt ttactcttga atgtgatgta ttcttctaag ctttatttta 2557141 catgatgttc tcctatatat cattcaatat taagatgcaa gacatctcaa aatcagatat 2557201 caactatgac ggactacatg aatattcagt tttttgtaga gccgccatgg gacgacacta 2557261 tctttgacac actttaatcc cccctgcttt atcgacatgt taactggtat gagagattga 2557321 caaaaagaag gaaaacgata tatttaagcg aatacgagtt tttgagtaaa ttttaaaatg 2557381 acactttttt caaaaatcat gtcttaacgg gaggattcgg tatgaatgaa tttatgaaaa 2557441 agttttcttt aacaaaaccg attattcaag ctccaatggc tggcggtatt acaaagcccc 2557501 gacttgcatc tgcagtttcg aatcaaggtg ctcttggcag cttagcatcg gggtatctta 2557561 cgccagacct cctagaacaa caaataaaag aaatatttga gctgacagac gctccttttc 2557621 aaattaatgt gtttgttccg ctaggtctag agatgccacc aaaagatcag attaaaaagt 2557681 ggaaagaaaa cataccgtta gctaatcaag taaatcaatt cacatctgta caagaagagt 2557741 gggatgactt ctatcaaaaa attgatctaa ttttaaaata caaggttaag gcttgctcat 2557801 tcacttttga tctgccgcct gaagacgcag taaaggagct aaaaaccgct ggatgctgtt 2557861 taataggaac cgcttcaaca gtagaagaag cattgttaat ggaagaacgg ggaatggata 2557921 tagtagtcct tcaaggaagt gaagccggtg gacatcgcgg agcattctta ccttccaaag 2557981 gtgaatctgc cgtaggttta atggctctga ttccacaagc agcagatgca ctgagcgtac 2558041 ctgtcatagc tgctggggga atgatagacc acagaggagt aaaagcagct ttaaccctcg 2558101 gagcccaagg cgttcaaatc ggttctgcct ttttaatttg tcacgagagt aacgcacatc 2558161 cagtgcataa acagaaaata ctagaagcaa acgaagcaga tacaaagctt acgacattat 2558221 tttcaggtaa agaggccaga ggaatcgtaa ataaatggat ggaagaaaat gaacagtttg 2558281 agacacaaac ccttccgtac ccttatcaaa atacactaac gaaggcaatg agacagaagg 2558341 cttcacttca aaataaccat gatcagatgt ctttatgggc aggtcaaggg atacggtcat 2558401 tgactgagga aatttcggtt aagcagcttt taaatcagct ttgccaagag gatataaaaa 2558461 tataggcgca cctcattgat agagcaaaaa gcaaactttg acaggcagtt tgcttttttt 2558521 ttcgtaattt catccactga ctctggaaat ctaaatactc ctacattttc aaagctaatt 2558581 tgaatcgggt tatcaatcat cacattgata cgatgcgatc ttgataattt caccacaacc 2558641 acaatacatt accaacattt cgatcttatc tccccttctc aagttttgct ccctattcga 2558701 ataatcgata gctcccatat taaatttgaa tagtaaaatg gttctttttc gtttgattca 2558761 gatgatataa agtcatatga taaaaaaaga atgagacaga aagcgtgaga agtgatgaaa 2558821 ataggatttt ttgattcagg aattggtggc atgactgtat tgtatgaggc cataaaagtt 2558881 cttccttatg aagattacat tttttatgca gatacgttaa acgttccata cggtgaaaaa 2558941 tcaaagggta aagttaaaga atatattttc aatgcagctg aatttctggc cagtcaaaat 2559001 atcaaagctc ttgttattgc gtgtaataca gctactagca ttgcgataga ggatcttcgg 2559061 agaaacttcg actttccgat aatcggaatc gaacccgctg taaagcctgc tataaataaa 2559121 tgtacagagg aaagaaaaag agttctggta gttgctacta atttgacgct taaagaagag 2559181 aaatttcata atctagttaa agaaattgat caccatgacc ttgttgattg cttagctctt 2559241 ccaggactag ttgaatttgc tgagaacttt gattttagtg aagacaaaat cattaaatat 2559301 ctaaagaacg aactatcttc ttttgatctg aaacaatatg gaacgattgt gttaggatgc 2559361 actcattttc cgtttttcaa aaacagtttt gaaaaactgt ttgggataaa agttgatatg 2559421 atttcaggca gtgtcggtac tgcaaaacag ttgaaaaaag ttcttgcaga tcgtaaccag 2559481 cttggtaaag gatcgggctc aatcaccttt ttcaattctg gccataaaat tgtggaccaa 2559541 gaagtcatat caaagtacaa aagattgttt gaaatattag atgaaactca aaggagtcat 2559601 gttggacatt gaatgtaaat gaaaaagaca atctcctgaa gagaaacatg aactaagaag 2559661 cgggcttaaa aagcccactt tttttctaac aaacaattga gttatacaca catatctgat 2559721 tacagtgttt tctctctttc ccctcttatt tctcccccct ctctatagct tttctatttc 2559781 aataaaacac aagtctcgat tgaaaagtta tcgtaacatt tacacttcac aggagatttt 2559841 tcacgattgc gaatcgaccg tttgccagat gcacaaagtc ataatgtgta aattctgtat 2559901 ctatgtgcat gtttattatg gaattatttt cataatgttt tataatacaa gatgatagcg 2559961 ttttctaatt ataatgatag ggggaaataa tgatgatgaa aaaaggtctg cttgcgggtg 2560021 cgcttacggc aaccgtgctt tttggcacat gtgcagtaga tgtaccgggt attattagtc 2560081 caaaaaccgc agaagctgca tcacagctaa ctgatggaat cggcgggagg gcttacttga 2560141 acagtaatgg tgccattctt gttacgaaaa tccagcttcc tagctccact caggtttcaa 2560201 atgggacagc ctacatctac tctggtttta gcggaggcac agaatccgat atcgggtttc 2560261 agtacagtga taaatataat gtatggaaac catatatgaa agtcggttca aaaggacagg 2560321 atcaggttca gtacctcgaa ggaggaagcc aattcacgaa tacgaaaggc ttccgtcccg 2560381 gcagcaccgt acaacttacc atctacaaaa accttaacgg caatacccgc gctacatact 2560441 ggggcacgaa caatgccgga tacaacggcc gtctcatttc agaaatcagc aaaacaaatg 2560501 tcggctccat ctcaaaatgg aaagcgctcg ctacagttgc aacaacaggg tcacgccaat 2560561 ctatcaaatc aaacttttca acatctttta caaacatcac catcgacaac aaagcaataa 2560621 cacctgtaat tgatacacaa gacttcgcta aagtaacagt ctcaggcaac agtgtcagtt 2560681 tatccgttgt caaaaattaa aacatgttaa acatacaatg cgttaggcta ttgagaagct 2560741 ctcgatagtc ttaaaggggg cttaacatgc cccttttttc atttcaattt aactttcagt 2560801 tagcttcggt acatgccgtc tatccccgtc ttttatctgg gtgaagtaag ggcagctcgc 2560861 cccttctgaa cctgttccat ttgctcaacg caaaaggtgt gcatcactgt cttaaaaatg 2560921 ttaaaacaaa tagcagatgg tgcactttat ttttagatga ggcatgctta cgctcgatat 2560981 gcaagtcaaa tgattaaggg tctgcaagag agagaagttt tgggtgtact ttcataaaag 2561041 agggatggct tcatatagct cgattgcatc aggaagatta gccaacgatt ggccgagaac 2561101 aacacatcac tttgaaacgg attcattcca aaatcataag tatgatccaa taactaataa 2561161 agatcagtta gcagtccagc cttaaaaata tttttacatc aattaaacta gcatcactat 2561221 cgaataagct cgatctgcat atcatgtact atcctctttt aaggaaggtg atgttatgag 2561281 gtcatttcca ttaatcgtag ttctattcat cctattaatc atcgttggga catctttctt 2561341 tggtggctat taagaacaca ccttacctca tatccatcag acgccataag aaatctttat 2561401 ggcgtctgtt ttttattaga tttaaacaaa accattaaag tgggccatgc aaacacacct 2561461 atggagatta ctgccacgac ttctttgtga gggaattatt cttcccttta tggactattg 2561521 tcgatcaaaa gagaaagttg aaatgcattt ttatggtgag atgaatcgag gcttagacat 2561581 ataaaaaacc gcaaagcttt cttgaagaag ctttgcggtt tttgggtctc ttctttgctt 2561641 catataagcc aatagatttc aagcgtaatc cactgccata catccaatga ttttttattt 2561701 tgaaataggt ttcttctact cttcatgtga gatgactcaa ggtatgccac gtcacaataa 2561761 tatggcggat actgaatggt ctcaatcagt tttttcccca ttctatcaat tctccacaga 2561821 aaaaatggct atggcagaac aactttcata gagtaatcat catttaatga gccatcatct 2561881 catgggcaat atcgtgtcca tccatttttg acgggtagta agtaggccag tttttgactt 2561941 catcaagtaa agcttcacgg tcgtcccccc aatagagatg gtaatgacta gctttagtcg 2562001 ggtaaatact atgatcacta aactgaatat actgaggcag cccttctgct tttttagcta 2562061 gtttgaatat gtatcttacc cctctattgc ccgcatcata ggttagaatt tcgtatccgt 2562121 catacgtata cttaccagaa tattcttttc catttttgaa gaacgttaca gtatctttct 2562181 ggattacaat acggtcaaca tctgtttgat agcctttttt ataatactct ttatattctt 2562241 cagctgtctt gccgccttcg tgttctgatt tatatgaaaa cacttcgtca agagtaccat 2562301 cttgcaggta tggatataca gattgccaat ctccttccca atcagaaagt aagcgatcct 2562361 ttacttggct gtttttaaaa tagccttcat atattttttc tgtttcttca tcatgcgcat 2562421 gactatgatc gtgagaatgt tcgtgtgtat gactgtcaga tgtttgctct tgcgttttgg 2562481 aagagtcttc ttcaactgct gaggatgatg ttgtttgatt agactcacct gcagaagaac 2562541 cggaagtctg acatcctgcc aaaactagta atgaaccaat cgttaatatg cctagccgtt 2562601 ttgaaaataa aatgttcatt ccaacactcc ttttttatta aatcgaaaac attacgattt 2562661 attatacata catctcttgc aaacatcaaa ggaaaaatgc tcttcatgcg gatggcctat 2562721 tttaaaggaa taactgacta tgttcatcag ttattccttt aaaatacgaa agtctacgat 2562781 atttccatat cgatccgctt caatgtgaca gcacccctca agcagctgtt ttaattttcc 2562841 acgtccgcgt tgtacccttg attttgctcc ggagtaagaa atgccgagct tttcactcaa 2562901 ctctttttgt gataacccct ggaaatcagt taactcgagc gcctctcgat acttttcagg 2562961 caaccgtttg atggtcgatc gaatacacac agttgcttcc ttggtgaaat tttcttcctc 2563021 tgcactgtca ttaaaatgta gaacatcagg caatatttcg cttgtttttt ttgtacggta 2563081 aaaatcaata atcgtatttc tagtgatccg ataaatccag ctgtcgatct tttgttcatc 2563141 gatcagattt gggagatgca cttgtatttt cataaatacg atttgcaaga ggtcatcaac 2563201 gatagattga tcgttaaccc tatgtgaaat atatgttttt aacggctgat gaaattgatc 2563261 ccatagatcc tctatattca tttgaaaaaa cctcctataa ttttgcgtct gctttacatt 2563321 tgcttcgtct ttttaatcgt aacaaagagc aaacaattgt tgaatcaatt gtattgcagc 2563381 tgttgccaaa aataatgata aaggagaggt ttgttgtgga gtatacctat ttagggagaa 2563441 caggattgcg ggtgagccgt ttatgtttag gcacgatgaa ttttggagtt gatacagacg 2563501 aaaagactgc gttccgtatc atggatgaag cacttgataa cggcattcaa ttttttgata 2563561 ctgccaatat ttacggctgg ggcaaaaacg caggattgac agagagcatc attggaaaat 2563621 ggtttgcaca aggaggacag cgccgcgaga aagttgttct ggcgacaaaa gtatatgaac 2563681 cgatttctga tccgaatgac ggaccaaatg atatgagggg cttgtctcta tacaaaatca 2563741 gacgtcatct ggaaggatca ctgaagcggc ttcagacaga tcatatcgaa ttgtaccaaa 2563801 tgcatcatat cgataggcgg acaccgtggg atgagatatg ggaagctttt gagactcagg 2563861 ttcgctccgg caaagtagac tatattggat ccagtaattt tgcaggctgg catttagtta 2563921 aagcgcaagc tgaagctgaa aaacggcgat tcatgggact cgtcactgaa cagcataagt 2563981 atagtttatt agaacgaaca gctgaaatgg aagtgctgcc ggctgcacgg gatcttggtt 2564041 taggagtagt ggcgtggagt ccccttgcag gagggcttct tggcgggaag gcattgaaaa 2564101 gcaatgccgg aactcgtaca gcaaaaagag cagatttaat tgaaaaacat cgtttgcaac 2564161 tcgagaaatt ttcagattta tgcaaagaac taggagaaaa agaagcaaat gtggctttgg 2564221 catgggtgct ggcaaatcca gttttaactg cgccgatcat cggaccacga acggttgagc 2564281 agctgcgtga tacgataaaa gccgttgaaa tcagtctgga taaggagatt ctccgcatgt 2564341 taaatgatat ctttcccgga cctggaggag agacacctga ggcatacgcc tggtgataca 2564401 ttcattactc aatactgaca tttttcttaa atatttatac tgaactatca tattaagaaa 2564461 gacaagagca tgtttgtctc ttgtcttttc cacatcgtgc tgaaaatgct ggctaaacat 2564521 cgacaaaaat gctgccgctt aaaaaagaac cctaaacaat agagtaactg gaaagacaac 2564581 tggcttgatc agcttgggac ccctttcagc tgtatttaaa tcaatcaaac taatgattca 2564641 ttggcagtct aaatattatt attgtttctt tacaaaatag taatagcccc tgtaatgatt 2564701 gctaacaacg taataactaa tgatgtaatt acagcccact taacggcaaa cctttgaaat 2564761 gaccccaagt ccattttaag catgcttact agcaatactg ttgacgcaac caatggactc 2564821 atcagatgaa ccggctgccc cattatagaa gcccttgcaa tttctactgg ttctatacca 2564881 tatgctgagg cagcttctgc aaagataggt accataccaa agtaatatgc atcatttgat 2564941 aaaacaaaag taaacggaat actagtgagt gctacaataa cggggaaaaa ccctcccatt 2565001 gatgagggga tgatggatat taatgatcct gctatggcat ccaccatctt tgtcccggat 2565061 aatataccag caaatactcc tgctgaaaat accaataata ccacggttat ggcattacca 2565121 gaatgctcgg cgattcgctc cttctgcatt tttacattcg gataatttat agtaagggca 2565181 agaacaaaac caattaaaaa taaaactgac ggatgcttag ttccaagcac aataaacacc 2565241 atgatactta taacgaggaa taaattaaga tatattaagc gtggcctttt caattgttcg 2565301 ctctccaaag tagcagccat ataagattga gagctgtcct ttgttatatg tctaggctct 2565361 aattgaacga tgcctattcg attcctctct ttccttccca ttagaaaagc cagaaatatc 2565421 acacaagcaa tacctccaag catggtcgga agtaatggca caaagaaatc tgaaggatcc 2565481 aaacccagca ctgaaatcgc tcttgtagct ggtccgcccc atggagtcat tccgctaacg 2565541 atactcaacg acagcattgc taatgtcgcc ataaccatgg gattcatacc aattctttta 2565601 tacaaaggta acattgctga gactgttatc atataggttg ttgtaccgtc cccatctaaa 2565661 gcgataagca ttgccaagac ggcagaccct atcgctattt tcacagggtc tccctttact 2565721 atagataaaa ttttttctat tagcggatca aataaacctg catcaattaa aattccgaaa 2565781 aaaagaatag caaacaatag caatgccgct gaacttgcaa ctgtttgaat tccttctaaa 2565841 atcatgtcgc caataccctt accaaaacct ccaataagag caaaaacaat gggagtgatg 2565901 gtcaaggcaa caataggcga gactttcttt gtcattatta atattgtaaa aacagttacc 2565961 atcgaaaaac ctaaaatagt aagcatatta cacctccaag aatgcgcttt caaatgactt 2566021 ttgattaaca tatcttatac ggtgtaataa gttaaataaa tattttttta ctgtgtttca 2566081 aaaaaaattc tatcataact ttaaatggtt accatttgtt caccctttaa aaaatcaatg 2566141 aatgctttaa cgagtttgat tcctaatgat ttttgatcgt acattagcca agtatctctc 2566201 attagaggct tacccttagc attatacagt tccattgtgt acaaatgatc agattcctgc 2566261 aggcaaattt ctggtgctat ggagtaacca agaccatgct ttaccatctc tttgcaagtc 2566321 tcttgtcgat ccacttccat tgcaataatg ggggcttgtt ttagattcgt atgcatccaa 2566381 tcttctataa tcgtttttaa agaagcatcc gttttatatt tgataaaagg taaaaaagga 2566441 agttgctcta tcgttattgg tttttttgag atgatatgta atttttcccg tgtcagccgt 2566501 tcctccaccc ctttccagcg atggcttcct ctcagtatac cgacttgtac aataccagca 2566561 tctaataatt tcatgacatc tgtgctccag cctgtttgta cactatattg gacattagga 2566621 tacatagtgg aaaattccct taataactta gggagcttat attgagcgaa attgcttgat 2566681 acccccagcc ttagatgtcc ttgcacctct ttgcttagat tagagatatg atctttggta 2566741 tcttgaagtt cctgtagcat tcttcttgca taagcaacca agtgttctcc ttccgcagta 2566801 aaggtaattc ctttatgcct tttggtgaat aattcaattc cgaaaatctc ctcaatcttt 2566861 ttcaaccgat aagtgatgga aggctgtgat gtaaataatc gttctgctgt ttttgttaca 2566921 ctttgttctt cgtgaagaat tttcaataaa atccaatctt tctcatccat tttcatcttc 2566981 ctttctagtc cttctttcac aattataaaa gtttttttat cgaatattaa gaaaacttat 2567041 attttatttt tattttttta ccttctacac taaaaaacat aaaaaatact acctttaaga 2567101 tgaggatgat gacgatggtc aagacgaatg taacaatcat gagaggcgga acaagcaaag 2567161 gcgttttttt ccacgaatca gccatgccta acaataaaaa cgaatgggag ccctttttgc 2567221 ttgatgtcat gggaagtcct gataaaagac aaatagatgg tttgggtggc ggtaattccc 2567281 ttactagtaa agtggcaata ataaagaaag catatacttc ggatattgat gttcactata 2567341 ctttcggtca agtcagcatt tcggaagaaa aggtggactt taaggggaac tgcggaaata 2567401 tctccgctgc tgttggtcca tttgctattg aagaaggact tgtaaaagcg aaagaaccaa 2567461 tgactgcggt aaggatcctg aataccaata cgaataaaat gatcattgcg gaagtagaag 2567521 tggaagacgg tcaggtcaaa tatgacggag atgttacgat atctggagta cctggatctg 2567581 gatctccaat ctatttaaac tttcatgatg ccgctggttc agttaccggt catttattgc 2567641 ctactggaaa tagttcggag tttttagata caagtcaagg ccaaatagag gtgtctatta 2567701 tcgactatgc aaatccatta gtttttgtgg aagcgagcag tatcggcctg gatggaacgg 2567761 aacttgcaga agaatttact gatctacagt tggctcaatt tgaagaatta agatccattg 2567821 cggcagagaa atgcggcttt gccagtcgat tttcagctac aaagttatcg ccggctgtcc 2567881 ccaaactggc tatagtagca aaaccagaga aatataaaga tagtacaggt gcttggcatt 2567941 caagcgttga gatggactta cacatcagga tgatgtccat gcaaaagcca catcaagcac 2568001 tggctgtcac tggagcgata tgtacaacaa gagccctttc agtggaaggt gcaatccctg 2568061 caagaatagc aaaaaaccac tctacaaagg ttcggctagc tcattcttct ggtattattg 2568121 aaacaatggt ggagcccact ggtataaaga tcgtccgtac cgcacgacgt attatggacg 2568181 gaacagttta tacgcatgga gactatcaaa tgatgtagat ggactgtgca aaaagcctcc 2568241 cccctttcca tcgttaatag atggattgaa tgcgccttct tgcacagatc cattgtaatc 2568301 ttgcatggct ttaaaaaagc ctctatattg ttttttatga aatcgccaag gtcctttcat 2568361 gtatctgcct caagcatgac ataatcatta tagagaaaat tgaatacttt ttactgcaaa 2568421 taaaaagata ccaacatcat tggtatcttt tagattgagt tcatctgcag cggtttcttt 2568481 tcctcactgc ttatttgatt acaaaattac cgtactcgtt tgaacgaaca tgaatcggtc 2568541 cgtttagatt atagttgttc tccttggcga tagagcgaag cacgtccaca cgggcaactg 2568601 attctctcca ttcgtcacgg gtgtcatgat tggccggatt catcagatcg tcatagcgta 2568661 cgtccaagaa tttattcaac cacttcttct cgtctattcc gtctttaggt gatccgcccg 2568721 cttttttgtt cgtacgttta atcaaggcat aaaaagagtc agggtcatca ccatcgccat 2568781 gctgaataac cgtatcgtac atcacagctc ttgccaatgc tgtttttagt ccggcattat 2568841 ccgatcgttt catggcaggc tgataataca aatggtcatt tactttgtct tgagcggcgc 2568901 gaaattcctt atcatttgca agcgacttcc aggcagaagc gaatcccttg agattgcttg 2568961 tatcatcgct ttcttccttg gccagacggc gcaattcagg cagatacttt ttcagtttgt 2569021 tattcggaac tgcctttgtg tatacttcca ctacttccaa tgcatccccg gtagccgttg 2569081 taaagcctgc ccgtccgcat gtatagcctc gcccgtcatc caatcgctct acatatccat 2569141 attggatctc cgttgtgccg ttttcaaaga tacttgtcag ctgttccgcc cggcgctttt 2569201 gatctttatt cagtcccgcc gcaaaaaccg tttcgctcat catcagggta aaaaacatgg 2569261 tgaaaacaag taatgagatc gctgcttttt tccaaaaatc tgctttttgc atactgattt 2569321 tcatttcact tcccctttct aaatattgta aatacagact cagtatacat gaagaaactg 2569381 ccctattgtt gaaaatacat caatttgtca atattttgaa tctaaagtaa tatagcttga 2569441 atcttactct attcattgcc aatcagcctt agcccctctc actgggaagg tcccttgatt 2569501 ttcatactgc ttcaactttc attaacaaga tgccataagg ctttactcta ttttataatg 2569561 gaagtgatca tcgaaaatcg ttagggaggt gatgtaatgg caagcaagat gagaatgcca 2569621 gattccgcaa cgtcccatgc aaagcctact attgggaagg cgatactttg catggggtag 2569681 actttctaaa agatcgccca agtaagcttt tctgatatag tggctttgca ccttatttga 2569741 cataaaaaaa taaggagctg gcagaaatgg catatgtaaa agcaaccgct attttacctg 2569801 aaaagctgat atcggaaatt caaaagtatg ttcaaggaaa aacaatatat atccctaaac 2569861 ctgaatcctc tcatcaaaaa tggggtgcgt gttcaggaac aagaaagctg atcgatgaca 2569921 gaaacgcttc tattaaaaaa gcatttaaaa acggcaaaac cattcatcaa ttatctgatg 2569981 aatatcacct ctctattgaa acaataaaaa aaattgtcta ctctaaataa acaaaacgga 2570041 agcactgata aaaaataatc agtgcttttt atatggcgag tttgtttctt agttatttcc 2570101 tgcatatgat accattggcc aattgtgtaa agttaaggga gatgagaaga aaggaaggtc 2570161 ctacaaatga cgataaacaa tggaacgttg caagtacccg gcgcgaacat ccactatcag 2570221 gtgcgtggct ctggtccaat cattcttttg gtccacggag gaggcggtga tgccgacaag 2570281 ttccatcatg ttgccaatca tctggctaac tggtacacgg ttgttactta tgatcgccgc 2570341 ggccattccc gcagcaatct cgccaatcag attgagggtt accgtgtgga aacacacagt 2570401 gacgatgctc accgtcttct agccaaaatc accaataagc cggcctatgt atttggaagc 2570461 agctccgggg ctgttatcgg gcttgatctg tgcatacgcc atcccgaaca agtacatgtc 2570521 atgatcccac acgaaccaat cttattgcag cttctgcatg gaaatgagct gaaacaagcc 2570581 gagcaattca tggaagacct taagaaaaat catcgaagtg aagtcattaa attaatgtca 2570641 agattagaga cagacgaaca atcaaaggct gtcctgacaa agcggcttct cggcaattca 2570701 acgtatttca ctgagtatga aattcaagga attctcagct atacattaga tttcgaagca 2570761 ttaaaaactg tgtttacatc ttcaccgatg aagatactcc cagctggcgg aagtgcttct 2570821 cgggagcttt ttccttatcg ttgcgcgaac gccctagcgg aacaattgga aacagaatgg 2570881 gttgaattcc ccggaaatca tacggggtac acaatgtacc ataaagaatt ttctgagagg 2570941 ttacacgaca tgttagaaaa agaaaagaaa catacgtgtt aaggattgat taaaattttc 2571001 aaaataggac aggtgaaact aactatggaa ttggagaaga tttcacgaag cgtaaaaaga 2571061 acttttcact aacgagaacg caatgtgaga tgtttaacca aagtgatatt agggatttca 2571121 tcgaaaaata ggtttgtaca ttacgttctc ctattgatta tttcctatct taattccgta 2571181 ttttatacca ttagatacaa ctctaaagcg gctcgttatt ttgtcctcaa caacaaccag 2571241 tgtctaacat catgaatctc ttttgaaaat caccacaaat gcaggtatgg aagacttcat 2571301 cgcagcaaaa accataccaa ctattgttgt tggtatggtt cgtcctagat aggcccttaa 2571361 gaagagattc tattgtacgg agtatttagc taattgcatt tgtaaccgac agggccgtct 2571421 gaacctgtgt acacatatgt gtcagacaca tatccaatat tcacgacacc ccgggaatct 2571481 ttccactgga tttggtccca gatattactc gttccatact tccctgtaac agtcgttcca 2571541 taagcgtaac aataataagg aacacgggag ccactcggaa tggaaagcat aataggataa 2571601 tttgtaccag gaccgctgcg catattgaca ggcgcaccgc tgcttgttga gacagtaaag 2571661 tactgaacgg caagtgcctg actggaaaaa atgaataaag atgcaatcat cacggttaac 2571721 atactcagca ttttcagttt agtcaatgtc atccctcttt cttcaattcc ttcattttaa 2571781 gaaacgatag aacataggct accagctgca tttaggaaca accggaccgt ctgagcctgt 2571841 atacatatat gtatcagaga caaatccagg aacgatctcc ccgctggcaa gcgtccgctc 2571901 tgtgtaattc caaatattgc tcgttccata ctttccagtt acagttgtac cggttttgta 2571961 gcaatagatc gggatgcggg ttccgctcgg aatggtcgtt acaattcccc aacttgtacc 2572021 tgggccgctg cgcatgttga caggagcacc gctgcttgtt gaaaccgtat aatactgagc 2572081 cgcaagtgca tggctagaaa aaatgaacac agatgcaatc atcaccgtta gcatacttag 2572141 cctctttaac ttattcacct tataccctcc ccttataaat gccgtacgtt tgactttctt 2572201 acatccagtt aaggatttac tttcagatac catgccccct cccctcccat atatttatca 2572261 atgtaccata aactagatct ttcaaaagtg gaattattcc tatgttttcg acaattaagg 2572321 atacaaaata aatggtagtc aggcttgata ttgatggtgt gttacatttg gctcttaatc 2572381 atttgtccag tcggtaatca cgattgacaa tcaggaaaaa ggacatggat caagcggctt 2572441 cgtttccacc aattaactca atcagtgtac tgcttccttg tatccacgct tcttctcgat 2572501 tcatagatac tccacctttt tcaccaatca aaaacggaca ccatacaaat cagcgtaaat 2572561 gctgcaagtt cagtgtccgc aacctattat gactttgctt tcttttacca gggcgtgtaa 2572621 aaatgattag gtacgttatc aaacgttatt ctatgatttt gcgagtcaaa aaatcataac 2572681 attttatata tttcaatcag attatgatct ggatctctga agtgagcaac tcgggcactc 2572741 cattccttgc gatcatgcgg tttattctca catttaactc ctttttcgtg taaatcgtca 2572801 tacgttttat caacatcttc taccttaaac tgaagcaaaa attttgattg agcttctcct 2572861 tccaaggact ttttttcctc tccaacgatt tcagccatcg tttctcgaga taaaagctct 2572921 attttcgttt ccccattatc aaagagtgca tattccattt cattctctaa ccaacttatt 2572981 ggaagtccta atgaatcttt ataaaactcg acgcttttct taaaatcatt caccaacagt 2573041 ctaatttgta acagcttcat atcgagtgcc tcctataaaa ccatactttt actggtcatc 2573101 caatttaatg ataccaaaga aacctgacag cactatgtca agtttccata cttcaccctt 2573161 atttcagatt taagtgcagt ttagtccatg tcataagaac gagcaaaaac agcgattctt 2573221 aaaacaaaaa atgataccga gtgtattttc tgtatgcttc aacttcattt cgggaaatgt 2573281 aacgttgata aaaggaggtt acatcaatat ggatcatcaa acattggcag ctcatgaggc 2573341 tgttgactta catgaaatcg tgaactttaa aacactttgt atagcgaaat caaagttaat 2573401 gcaagggctt gtgtttgacc aagaactgaa ggacttgatg gaaaaagatg tacagcaatc 2573461 cattcaagac cttactgaat tacaagcggt ttatgagcgt gcctcatttc aggcccctgt 2573521 ccctcaaagc cgcccaacgc caatcatcaa ttgaaaggga ggtaagcctc tttgaataat 2573581 gatcatttag accccattaa ttcgctgaat gtgcctgaac tagcagacac tacattcgcg 2573641 atggattttc ttatacgagc taaggaaggc gtaaggaata ctgctgtagc tttgacagaa 2573701 accgcttcac cagatgtaag agcactgctt cggaaacagc tgatgcaagg aattgcgatg 2573761 caccaagaga ttacggaact gatgatcagc aaaaagtggt tccatccata tgagctgagc 2573821 gaacagtata agctggatca gctctctgca aaaaacacga tcatggtcgg caatatgaac 2573881 ctctttcctg atgaaacaaa tcgcaaaggg atgtttgacc ggacacctga tgaacactaa 2573941 cactggaggt tttacagcat gaaggcagta acgtatcaag gcattaaaaa tgttgttgtc 2574001 aaagatgtcc ccgatccaaa gattgaaaaa tccgatgaca tgattatcaa agtcaccagt 2574061 acagccattt gcggatcaga tttacattta atccatggat tcattccgaa tatgcaagaa 2574121 gactatgtca tcggccatga accgatggga atcgtcgaag aagttggttc tggggtgact 2574181 aaactaaaaa agggagatcg ggtaattatt ccctttaata tagcatgcgg ggaatgcttt 2574241 ttttgtaaaa accagctgga aagccaatgt gatcagtcta atgacaatgg ggaaatgggt 2574301 gcttatttcg gctattcagg gcaaactggc ggttatccag gcgggcaagc tgaatattta 2574361 agagtgccgt ttgcgaattt tacccatttt aaaatccctg aatcttgtga ggaacccgat 2574421 gagaaattaa gcgtgattgc cgatgccatg accaccggct tttggagtgt ggataatgcc 2574481 ggcgtaaaaa aaggcgatac agttatcgtt ctcggctgcg gaccagtcgg cctgtttgct 2574541 caaaagtttt gttggctaaa aggcgcaaaa cgcgtcatag cagttgacta tgtaaactat 2574601 cgcttacagc atgcgaaacg tacaaacaaa gtagaaatcg ttaattttga agaccatgag 2574661 aatacaggga attatttaaa ggaaatcacg aaaggcggag cggatgtagt cattgacgct 2574721 gttgggatgg atggtaaaat gagcgatctc gagttccttg ccagcggctt aaagcttcat 2574781 ggcggaacga tgagtgcatt ggtcattgct tcccaagctg ttcgcaaagg aggaaccata 2574841 caaattacag gtgtgtatgg aggcagatat aacggttttc cgttaggaga tattatgcag 2574901 cgaaacgtca atatacgctc tggacaggct ccagtgatcc actatatgcc gtacatgttt 2574961 gaactagtat cgacaggcaa aattgatccg ggagatgttg tcagccatgt cctgccgctt 2575021 agtgaagcca agcatggcta tgacattttt gattcaaaaa tggatgattg tatcaaagtt 2575081 gtgttaaagc cttaaaaaac ggaggttaca gaaatggaat acgccttaca cgaagtgctt 2575141 gaggttcagg aaatgactgc atttaagaca ctttgtttga cgaaatctaa aacaatgaaa 2575201 gcactggtat ctgatccgaa gctgaaagaa atcatgcagc aagatgttga tatcaccaca 2575261 cgccagttgc aggaatttgc ctctatttta tctaatgcaa agcaagaatg aggagatgaa 2575321 taaatcatga atcctatcat agaatatctg actggcatga atgttctaac agaccaaatc 2575381 attgctatgg acttattaat ttcagcaaag aacggagtca gaaattatgc gatggcagcc 2575441 actgaagccg gaacgcctga agtaaaagag gtccttatcc gccatttgga agaagcactc 2575501 gatatgcacg aacaactctc aagctatatg atggaaaaag gctggtacca tccttggaac 2575561 cctgacgaac aagtcaagct gaatttaaaa aatattgata cagccattca attgccaacc 2575621 ctttaacata caatgactga tttgctgagg aacagtattg attggccaca actgttcctc 2575681 agcttcaaaa tgagcactgt ttgttcgggt cctatgaccg taaatagatt aaccgctttt 2575741 ctccatctga tctccgataa tgtttgcaaa ttctccaatc caaataagga atcgtaacca 2575801 cctcttttta tgcgatctct tgatggagaa aacaggccag aaacaaaatc cttcgttttt 2575861 gacctgccct cttcacacgc aaagaatgct accttctttg ctccactgat ccgtgaagac 2575921 tttccgtttt aggcctgctt ttgagctttg cctcattttc acgcaatttc ccatcataat 2575981 ctttaatttt tgtgtctaat ctcttaattg tttcatcaat ttctttccgc ttctctatca 2576041 gccgctgtcg ttcgtcagcc aggatatttt ttcgagcttc taccgtacgg tcaccttcgg 2576101 taaataatgt tgtatattca attagcgctt ctatcgatag tcccgcattt cgcatgcatt 2576161 taatgaattc aatccatttg atatcttctt catcatagtc gcgaatgccg ctgtcttttc 2576221 gttttacagg cgggattaat cctacacgtt cgtaatatcg gagtgttgcg gctgtcaggc 2576281 caaactgctt tgccacctga gcaatattca tgatcttcac ctctctatcc tgtatgttgt 2576341 gaaggtaaca cttaaagtta actttaagtc aagctcaaaa caagtggtta gctgctgaat 2576401 ctgggtttat atattcggga cttgccttaa agcacacttt aaactctata cttctccatg 2576461 cactaaaaac agtgtagttg gagggattgc tgaatggcaa ataaacacac tgccggaaga 2576521 gaacaattag gagaatttgc gccaaagttt gctgaacttc atgatgatgt tctattcggt 2576581 gacatttggg caagagaaga agaactttca tcccgggatc gcagcatgat tacagtttct 2576641 gcattaatta ctgactgttt ctcagcttat aaatcaggtt cattttaaat ggttttttta 2576701 aaaaaccctt gccttaaagc agactttaag gtttatcgtt atgttgaaga caccataaaa 2576761 cataaataag tgcatgtttt tatttacaac acttatgatg aagaaaggat aggttcgtat 2576821 gtgtaatcaa catcaaaccc gtgtattaag cgtgtcacat gcaaaagcca aatttgaaca 2576881 aacgacgatt gagcgaagag gattacggcc gcacgatgtc ttaatcgata ttaaattcag 2576941 cggcatttgc cattcagaca ttcatagcgc ttttgatgaa tggggcggtg gcatcttccc 2577001 aatggtgcct ggacatgaaa tagccggtgt tgtaacagcc gttggaacaa aagtcaccaa 2577061 gttggctgtc ggggaccgcg ttggtgtcgg ctgttttgtt gactcttgcg gagaatgcga 2577121 atactgtctc aacgcagagg aacaattctg cacgaagggt gttgttcaaa cgtataactc 2577181 agtagactac gacggaaacc ccacttatgg cgggtacagc caaaaaatcg ttgtcactga 2577241 cagatttgtt gttcgcatac cagatcgttt ggaaatggat gttgccagtc cgctgttgtg 2577301 tgcaggtatc acaacgtatt ccccgctgaa acactggaat gttggccctg gtaaaaaggt 2577361 tgcgattgta ggcgtaggtg gccttggaca tttggcaatt caatttgcac atgcgatggg 2577421 tgcagaagta accgtcctga gccgttccat gaataagaaa gaggaagctc tggaactcgg 2577481 tgcaaatcat tactttgcaa caagtgaccc agccacattc actgcattgg ccgggcgttt 2577541 tgacgtgatc ttaaatacgg tatcggcaaa tctcgatgta gatgcctatt tatcaatgct 2577601 tcgtatagac gggacacttg taagcgttgg agctcctgcc aagccggaca catacagtgt 2577661 gttttcccta atcatggggc gccgcagcat tgcaggttct ctagtcggcg gaattcaaga 2577721 aactcaagag atgctggatt tcgcagctga gcatggcatc gaacctaaaa tcgaagtcat 2577781 cggagctgac caagtggacg aggcatacga acgtatcctc cgaagcgatg tccgttatcg 2577841 atttgtgatt gatatttcca cattgtaata ggttagtcct tatatgggct gccgctttta 2577901 ttgaaactca cgaaaaatga tctctttaag caaatatttt gaaggccggt caatcttcct 2577961 gttattctat gaatagagag ttattaggag ggttttttat gagcaaaaaa attgcagttc 2578021 ttgttacaga ccaattcgaa gacatcgaat atacaagtcc ggtaaaagca tacgaagaag 2578081 ctggctacag tgttgtggct atcgatttgg aagccggcaa agaagttacc ggtaagcatg 2578141 gcgagaaagt aaagattgac aaagccatct ctgatgtgga tgcaagtgac tttgatgcac 2578201 ttttaattcc tgggggattc tctccggatt tgcttcgtgc agatgaccgt ccgggtgaat 2578261 tcgcaaaagc atttgtcgaa aacaaaaaac ctgttttcgc aatttgccac ggcccgcaag 2578321 tactgattga tacggatctt ctaaaaggca aagatatcac aggctaccgc agcatccgca 2578381 aagatttaat caatgccggt gcaaactaca aagatgcaga agtagtcgtc agccacaaca 2578441 ttgtcacaag cagaacacct gatgatttgg aagcatttaa ccgcgaatct ttaaacttgt 2578501 taaaataaca agaaggcaca gactgttcgg gtctgtgcct tttttaaaat taagactcct 2578561 tcgttacatt ctgaaagaca gcagtcgcgt cccacacatt caagccaaat tggccttctg 2578621 aaaatacgga atcatgtgca tcaatcacaa gacgatcatc taaatagatt ttaaagcgat 2578681 cgccctcggc ctctgttttc agatgatact ttttattaac gtctatcggt gttttgtatt 2578741 cagcaatgac agaagcagca ccgttctcaa atttaaagaa tttcactagg tcatgcttcg 2578801 catccacatt ggcaaggtaa ccgtttttgg catctttgtc agagcgaaac attagtgctc 2578861 ctgcccctct tccgtttcca tccttaatgg tgatatcaga ttcataagtg aagtctgacc 2578921 cggatgctga agacaagata aaggaatcgc cgtccgacct cccttgtttc ccctcaattg 2578981 tgtctgccca cgtgccattt acagtcgtcc agccagtcat attggacata aaaggtgtcg 2579041 ttccccatac cttttttaaa gggtgtatcg ttaaagattt tacctttaca ccgccatttg 2579101 cagcatataa ttcaagccct ttgcttgatc ggtctgggag aataatatcc gttatgacct 2579161 gctttccgtc attcccaaat acttcaaccg aggagcggtc aacaaaaatg cgcaacttaa 2579221 ccttcccatt taccggcttc aacggggctg tttcttttcc ggtgttaaag gccggattaa 2579281 aggtgtcgtt gcctgactcg ctccggtcaa cgaacaattt ggcgttcctt cggtcatagc 2579341 cgaccttcgt aaattgattt tcacctgttc ggaccttaaa accaaattca gcagctgaac 2579401 cagggcttac tttaaattct gcatttattt cataggcatc tccagattgc cccgctaaca 2579461 cattatgact tgcaggcgat atggtcagat tcttccactt cttagaggtt ccgcgaatgg 2579521 tttccagctc tttcaccggt gtttggacca ctctaacccc ttcggtaaac gctttcaatt 2579581 ttaactctct tggaatggac gttgcacttc tccatgggga tgtcggaaca tcattcgcat 2579641 attgccaatt gctcatccac cctaaccata gccggcggct gtctgtggat ggaatatcag 2579701 accaggatac agccgcataa aagtctctgc cgtaatccgt ccagagaact ttgtttggcg 2579761 ggttttcatt tttaaaatga gttccatcaa agtcccctac aaaatattgc atgcctgatc 2579821 ctcccgagac cgctccgttt ccgacactga cctgcatgac ccatttcttt tgattcggat 2579881 tgccgtctac cggaagctca aataaatccg ggcattccca tactcccccg tggcttcctt 2579941 gatcctgtcc aaattcactt gcatacgtcc actgcttcag attttttgat gtataaatga 2580001 ggattcggtc accggccgca agcaccatca cccacttttt ttctttctca taccaaaaga 2580061 cttttggatc gcgaaaatct tttttacccg ggtttggaat gacagggttg ccagcgtact 2580121 tcgtccatgt tcttcctttg tcgttgctat aggcaatact ttgcacttga tggccttccc 2580181 gatcctgtgt ataaatggcc acaagcggct tctctttgcc tgtttgaaaa ccgcttgtgt 2580241 tatttttatc tacaactgcg cttccagaaa agatcgtgcc tttttcatcc ggatacagcg 2580301 caacaggaag gtgttcccat gtaaccaaat ctttgctgac ggcatgcccc caatgcatgg 2580361 gcccccactg aagcccgtat ggatggtatt gatagaacaa gtgatattcc ccagcataat 2580421 ataccattcc gtttgggtca ttcatccagt ttgcctccgg tgtgaagtga tattgaggac 2580481 ggtaatcctc atcatagtag cttgaatcgg ctgcatctgc cgaaaatgcc atagtcaaca 2580541 gcagggtgaa catgatcatg acttgaatca gtctcttttt catttgttcc ttcgctcctc 2580601 tcttcatgtt tgaacacttt caaaagagac tgctgcgcaa gctggtccgt ttctggcaat 2580661 tctcctctgt ttcactgtta tccgaatgat ttatatatga aaagactgct gcagtttctc 2580721 tctctttcct tcacacacct tatgctaaga atccagccca atacccgaga atcccgatga 2580781 caaagatgcc gcaaataatg agaagtggat tcaccccttt gcgaagcatc catgccacca 2580841 ataacgttaa tccgagaggc agcgcccccg gcataatgct atctagcacg ttttgtaccg 2580901 tttgaacatc tacttttccg ctttcatcct taatcctgga tacaacgatt ggaatgttga 2580961 tggtggtcca tttggacacg agagccccca taacaaataa cccgagaatc gaagcgccct 2581021 ctgtaagctt ttgaatgcga ttccccgcta aatcctgaag aatctccatt cctttcacat 2581081 agccatactt taatccgtaa tattttgtgc ttaatcttat ggcattcagc aagaaaaaga 2581141 atagcaaagg accggcaatg tttcctccta aagcaaggga ggctcctagc gcagctaaga 2581201 caggacgaat cgttccccaa aaaattggat cgcctacgcc cgctattggt cccatcaaac 2581261 cgattttcat tccgcttatc gcttttccgt caattccttt attgttcgcc atttcttctt 2581321 ccatggctgc cgtcacgcca aatataggcg ctgtcagcca cggatgtgta ttaaaccatt 2581381 ccaaatgccg ctgtaaggct tcgtttcttt tcgctccggg accgtacaat tttttgatcg 2581441 ccggtatcat gacataacaa tatcccattg cctgcacacg ttcgaagtta aaggaaccga 2581501 gtaaaaaatt tgaacgaata aacatgctga aaatttcttt cttcgttaat cgtttttctt 2581561 tctccatttt ttcttccccc tcatcgttta ggcatcaaga tcatcatcat cgtcatcata 2581621 aacagcaaca ctgccactgt ctgatgcggc cgcgactgct ccgtgagcgc tttgtttttg 2581681 catcacctgc tggtataaaa gcgccagaca gagaccaagg gctccaaatc ccactaagtt 2581741 aaaatcggta aacgccgcta ataagaaacc aatatagaaa aatggcttta aataaggaat 2581801 attcatcata ttgatcacca tggcataccc gacaaccaca ataatgcctc cgcctatttg 2581861 cagtcctttt gtaatgacat caggaatatt tcccaggaac gcctgaacag cgctgacact 2581921 aattaaagca acaatcaatg taggaatcat gacgcgcaaa gcttgaaaca ccatcgcggt 2581981 aatatgcata atttcaattc cttttatatt tcccgctttt gcatattgat cagcgcggtg 2582041 gatgaaaaag acagtgatcg tccgaacaaa aatcgtcagc gcctgacccg cagctgctaa 2582101 agcaacagcg acagcaatcc cttcgccaat tccttgatca gcggtaataa ctaaaatggt 2582161 tgagatgaca gaggcgatcg ctgtatcagg tgccatggca agcccgacgt tcatccagcc 2582221 gagcgccatc agctccagtg tgcctccaag aataattccc gtttttaagt ccccgagcac 2582281 caagccaacc aacgtacagg ccactagcgg ccggtgtgtc tgcccttcat ccaatacact 2582341 tgcgattccg gtgattgctg caatgattaa caacaaaata atttgtaatg aagacatatt 2582401 ctcatcccct tgattatttt gttacgttcc gtaaaatctg tacaaaatcc tcactggcat 2582461 ctgaaggcag ctgcctcaat tccagtttca cgcccttgtc acttaatgtt tcaaatgcct 2582521 ttatatcttg ttctgtgaca ctgactgatt ttgtgatttg cctgcgatga ttttcaaaac 2582581 gcattccccc gacgtttacg gttttgatcg gtacacctgc ttctataaga gatacaatat 2582641 cggacggatt ttcaaacaag agcattgccg ttaccccttc gtagcgcgga ctatgaaatg 2582701 cttttgccat tttagaaacc gagacggcac tcgcctttac atttgaaggc gcaacagaaa 2582761 ggatcagcgt ttttctcatt tcgtcctgag caatatcgtc ggagacaacg atgattcggt 2582821 cggctgcatg gacttttatc caccttgtca ggatttggcc gtgaataaag cggtcatcaa 2582881 ttcttgctaa cacaatgttc atcataattc atcctctctt gtatcttgat tggctgtttt 2582941 tactttttct aaatgttcac tgcacacttg aaagctttgc tgactcattg cttttaagtt 2583001 gttcagcaaa tctttgagag ccagatgttc tctcaggctt aatacctcca gcagaatcgg 2583061 caggtttacg ccggcagcca tatccattct ttgatcctca gcaataaagg aagctgccgc 2583121 gttatatggc gtccctccaa aaatatcgac taaaaaaagc acttcatgtt cttccgggat 2583181 atccttgagc gcctgatgat atttttcttg cagcgtttgt attccttccc ctttgaaaaa 2583241 cggcactgca atcaggttat tttcttcacc gaatatcatc cctgaagact cttttaatgc 2583301 tatgggaaaa tctccatgac cgctgataat aactgaaatc atatctattg ctcctttcct 2583361 gttttgtaca tccatatata atgcaaggat cgtgccaaca cagttgtgtt aagcgttttc 2583421 attgttattt cagccaatag caatttgttg ttgaaacact taaaacgaaa aaaataaacc 2583481 tgtattaaaa tggtgttcca tttaatacag gttcatatga aaaaactgtt tttaaaacag 2583541 ctggccatgc acttcttcag caaatatggc ggctataaat aatttttcat catcacttat 2583601 gcgaagtccg agcttttctt cataaggggc taatgttcgc tctgtcacgt acaccatttc 2583661 cttcagctga tcattgatct cttcttcctc tgagaaagcg atcggattct gcttaattac 2583721 cctttcaaag gcgaaagccg tgtgcataat gactttgatc aaaaccgcat tattgaaaat 2583781 gacccccagc tcatcctgaa cggtttgcag ccactccaat aacatgtcga tcacatggtg 2583841 gggattcaag aagacaaggt attttttcag gctatcctcg caaagctccc tgacaataat 2583901 atttgcttcg ttcaatccat tgctcaagga gatgcttcct tttgtaatcg cctgttgaat 2583961 cagcttctct ccctcccctt caattaacac ttctaaagat acatgcggag cattgatttt 2584021 agggtctttc gttccgactg tcgcaaggat ttcatactct ttttcgattt cttttatgct 2584081 gttggccagc ttaatcgatg atacggtcaa tatgtgaatg ggggtatcgg aggccttgtt 2584141 tacgatcgtg gttagaatgt cttccagctt tttggccgtt ccgctacccg tcgtgcagat 2584201 ggataccaat gccttctttt tgccggatgc cgctggctga cgctcccaca actcgataaa 2584261 atccttcgtg accgattgat agatcgcatg caaatttaaa ttcaaatagt tgacctttct 2584321 gacagcatcc agcaccattg aagtcgtaac attgctgatc gttttaatag aaatgcctgt 2584381 cttttcctcc agcctgcttt ccagcattgc aagcgacccc atatctacca gcattaaaac 2584441 accttcacct tcatcaacct gtttcatttt ttctgctacg cattcaagaa tgtccgaagg 2584501 tgaaacagta agcggcatgt caactgctgc aatcggcgta ctccctagca gttctgtcgc 2584561 gacttcaacc attgaactcg ccgtgctgtt tccatgagct gccacgataa taccgactct 2584621 tttgttctcc tttaacgatt tgatggaatg aattaacatc gttaagtaga tgacttctat 2584681 ttcaggaata gccactttaa aatattcctg aattttatct ttaaaaatca tcgccacccg 2584741 atattctttc acatgggtat cacgaatttc atctgtctcc tgtgtattca aaacatcaat 2584801 ttgctttcct cgctttaaaa atgcgtcaat atgcatactc aagaaataaa taaacttacg 2584861 gtcaaatgtg caatccagct catgttcagc tatttctttt aactgttttg tcatttgaat 2584921 cacatcgtct tcaacgaatg tcagcaggtt gtctttttga aaagcttgat gatgaaaaaa 2584981 acttctgaca tgcaaatgga catcagtcaa gatgtactgg ttaatatcct ttttggataa 2585041 accttctttc ataagcgttt tcactttttc ctcaatcaaa tgatataagt taaatgagag 2585101 gtcttcgtca atttttgttg tttcatcttc tacaatcgga gagataatcg ttgtaatatt 2585161 gacatattca gaaatggctt tgcttctttg catgtttttg ctgctggaca tccattcttg 2585221 cttgatttca tcaggcagat cgcgaacagt cagttcaata acttcatttc tgtcaaggtt 2585281 atgcaaaaat ccgtgtgcgc aaactaactg aacatttgat ttcagctgtc cgacattccc 2585341 aaatttcgca gagtgaataa gcgcattata gacatcgata tgcacactca gattcttctt 2585401 aattcgctct gcttctttcc ctaataaaaa cgtcgtcaga tccactcttt cattaagcga 2585461 tcgttcttca agcgaaggaa tatgaatggt cattgggatt cttcgcaaaa acgttttcaa 2585521 tagtgcagaa ctcggatttt ctgtagtcgc acaaataaac aatacgttcg atgttcgttt 2585581 atgttcagat tctccaagcc tgttataaga accgctgtca ataaaataaa acagcatttc 2585641 ttgtccctcg ggagggagac ggtggatttc atccataaaa agaatgcccc cattggcctg 2585701 ttcgactaaa cccgccttat cctcggcagc acctgtaaat gaaccttttt tgtgtccgaa 2585761 taattgagaa agcaataatt gagggttgtt gtagtagtct gcacagttaa atgtaataaa 2585821 tggtgcgccg gccttcaata tgtcagagta aatggcaaac tggtaaattc ggttcgcaaa 2585881 aagggattta ccggaaccag tcggccctag gaggagcata tgcagaccgt tcggcggata 2585941 aaagacagct gcttttgcct gggagatcgc tttcttcaaa ctcccttttg cccctatcat 2586001 aagctctagg ggattcgtgg aaatgtgttg atgattttgc tttgaatttc cggaaaacgc 2586061 ctgaaggtct ttcacttcca tcatctctgt atcccatttc ttgttgaata atttttctgc 2586121 tatctcgact gggatgtatc ttacaggaaa tgttttaatt ttgatgacct ttttggaccg 2586181 gacgagattg ttcaattcaa agctgacatt ggaccgctcc attttcagct gctcggcaat 2586241 ctcctttgct gaattccctt gtatttttaa aagatgatct aaggttgaat catgaaaatt 2586301 atgcttgagc tgatggtata ttttatctat tcttctcacg tctatcatcc tttgtcctta 2586361 ttagataagc cattaacaag aatatttcga aactttatag tccgcgttga gatttacacg 2586421 tttaaaaagg tctctatagc agattgacaa agctggcttt tatgcgtata tgtttacatg 2586481 ttgaatcatt tgcacctcat attagtatga tagatgctca gttctggagg gccagtcccc 2586541 ttcaaaagta ataatcagta aacagtttat cattctcggg gaatgtaatg atgtcaaaat 2586601 aatcaatgac aaaaaatgaa tcttatagat catgacaaat tacccaaata taacccctta 2586661 agttcgttca caactaaaaa gacggacact ctatgtgacc gccacagtat tacaatttgc 2586721 aaaacttcgt catttttgca atccacattg gaggttaagg aatctgtaag cttaaaaact 2586781 ttatctccga tcctatcgat ttgatccccc tgccggcctc aatcatagtg ggtatgcaat 2586841 tatacaaatc gttaccgatt aaaactagcc tgtcagattg tccaaatgac tttcctgttt 2586901 tactctgcta ttcaggtaga atcacgagtg aaaaatagag ccacaagaca tgtaacagca 2586961 cttaaaatag ttttaaaatt taaaaataaa agtatctatt cttttaaatg ttataatatc 2587021 cgataaaact ttactcatct ttttattact ggaggaaaat aaaattgata ggcaattcta 2587081 gcaaagacaa ttttggccag caacagaaat tgtctagagg ccttaaaaac aggcatatac 2587141 aattaatggc gattggaggt gcaatcggta caggtttatt tttaggttca ggtaaatcca 2587201 tccattttgc aggaccatcc attttatttg cttacttgat caccggcgta ttttgctttt 2587261 tcattatgcg ttcgctcgga gaactgctct tatcaaatgc gggataccac tcttttgttg 2587321 attttgtaag ggactattta ggaaacatgg cagcatttat cactgggtgg acctactggt 2587381 tctgttggat ttccctcgcg atggctgatt taacggcggt cggcatttat acgcaatatt 2587441 ggcttcccga tgtgcctcaa tggctgccgg gtcttcttgc gcttattatc ctgctgatca 2587501 tgaaccttgc caccgttaaa cttttcggag aattagaatt ttggtttgca ttgatcaaag 2587561 tcattgccat actggctctg atcgtaactg gtattctcct gattgcgaaa ggtttttccg 2587621 cagcttccgg ccctgccagc ctcaacaacc tttggagcca cggcggcatg ttcccaaatg 2587681 gatggcatgg gtttatccta tctttccaaa tggtcgtctt cgctttcgtg ggtattgaac 2587741 ttgttggact gacagcaggt gaaacagaaa atccccaaaa agtgatccct aaagccatca 2587801 atcaaattcc tgtccggatt ttactttttt atgttggcgc acttttcgtg attatgtgta 2587861 tctatccttg gaatgtgttg aatccaaacg aaagcccatt tgttcaggtc ttctctgcag 2587921 taggcatcgt tgtggctgcc agtttgatca attttgttgt attaacatca gccgcatcag 2587981 ctgcaaatag cgctttattc agcacaagcc gaatggtcta ttcacttgca aaggatcatc 2588041 acgcacctgg actattaaag aaattaactt cttctaacgt gccaagcaat gcgctgttct 2588101 tttcatccat cgccattctg attggcgtta gtctgaatta tttaatgccc gagcaagtct 2588161 tcacgctgat tacaagtgtt tcaacaatat gcttcatttt tatttggggc atcacggtga 2588221 tttgccattt gaaatatcga aaaacaaggc agcatgaagc gaaagcaaac aaatttaaaa 2588281 tgccttttta cccattatcc aactatttaa cacttgcatt tctcgcgttc attcttgtca 2588341 tattggcact ggcgaatgat acacgtattg ctttgtttgt caccccggtc tggtttgttt 2588401 tattgattat tttgtataag gtgcaaaccc gcagaggaca taaggtgaaa taaaaaaaag 2588461 acaagggata ctcactccct tgtcttttta tatgtgtcaa acactaaatt aaactttggt 2588521 ttcaaatttc attcacttca tttaagtgtt aactcaaacc agttttgatg ccgaaaccta 2588581 ctaatattat tccggtaatt ttttgaaaca ctttctggaa cttcgagttt ttcatccatt 2588641 tttttgcgta atcaataata taaacaagaa acaggaacca caacaccgct aataaggtta 2588701 ggattgaagc taaaatgatg agctgctggt ttatatttcc gttcaaattg ataaattggg 2588761 gcatgattgt aacatacacc aaaacagttt taggattgag aatgttactg agtgatccct 2588821 gcataaagga agttttataa taacgtttcg gagaacttgc catatttttt gcttgggatt 2588881 gcatgtcatc taacgaaaac atacttttag caaaaaaact ttttacacct aaataaatta 2588941 agtatgccgc tcccaaatat ttgatcgttg tgaaaagaat cactgacttt gcgattacca 2589001 ctgataatcc taaaatggca atcaccgtcc aaaaggaaag tcctgtcgcc aatccgagaa 2589061 tgttataacg gccggctttc ggaccatacc taagcgtatt tttcatcaca agcatcgtat 2589121 ctgcccccgg tatgataacc atcatggcag cgatcggtat gtatgcgagt aagctgtgca 2589181 ttgttctctc cccctttaaa aatcccctca atcatatagt gactacaaaa gtaactactt 2589241 ataaaagtgt atcaatgcgt ttggaataaa tcaatatgat ttgttaaaat agcgattact 2589301 aaggcagcga ttgctcttta tattggagga tatatgaaag aaaatatgtt agacatttta 2589361 aaaaacctca attttacaga atatgaatcg aaagcgtatt tagcattatt gcaagaatca 2589421 cctttaacag gctatgccgt tgccaaaaaa tccggagtgc cccgttctaa aatttatgaa 2589481 gtattggaaa gtcttgtcat aaggggagat gtttttgtca gtcatggaaa tacgcctcag 2589541 tatgttccag tccccgcaaa agaactgatt aaaaaccgcc ggctcaaagc ggaagagcat 2589601 tttgatcagg ctgagaaata ttttgaaaag ttcgagcaga ccgcaaatga ccgggaaaac 2589661 atctggaata tcaccggccg cagtgaaatt cttgaaaagg tgaaggcttg tatcttatct 2589721 gccaaaaaaa gaatcctctt agaaatatgg aaagaggatt ttaaggagat agaagcagag 2589781 ctcaaacagg cggcagaaca aggcgttatt gtcaccatta ttgcgtacgg agacatcgta 2589841 tctgattttg ccaatgttta ccttcatgat atgagcagtg aaattacaga agagtatgac 2589901 ggacggtggc ttgtctatag cggagatgat tcagaagtag tagcgggcat tgtctcactt 2589961 ggcaacgaca gccgtgctgc atggacgatg catgtagggt tagtcatgcc tattactgaa 2590021 gtgatcattc atgatctgta cctcatggaa attctgaaaa agcatagaga gcttttagaa 2590081 gagagcttcg ggaaaaatct catccagttg cgccgtaaat tttctattca ctcagatttc 2590141 aaaaaacatt atttggaata atgtttgtca tctcttaccc caaaaacaag gcttgtacaa 2590201 aacaagcctt gtttttttat gcataaaccc cccatgctga tttacttctc tcttttaaaa 2590261 aatgtgattc tgcgcaaact atttttcagc ctgccgcgtc tatcctaggt aacagcctac 2590321 gatatacgta tattcaaaaa ggagcccttt attgcaatga agaaaaaaca aacaacaaaa 2590381 gcgttgcttg tcacatgcat aactgaccat aagcaagatt tctacaggtt ggctttcagt 2590441 tatgtgaaaa atcaagatga cgcattagat attgttcagg aatctataaa aaaagcgctg 2590501 agctcagttg aaacggtcag gaaccctgag acgataaaaa gctggtttta taaaatttta 2590561 gtacggacag ccattgactt tttgcgcaaa caaaaaaaga taagagtgat ggacgacgaa 2590621 acgatagaat ttttaagcaa aggaaaggaa gaccattaca aggatactga tctccatgaa 2590681 gcgcttgacg aattgccgta ccgctataaa accattatta ttttacgttt ttttgaagac 2590741 ctcaaattag aagaaattgc ggaaattaca ggagaaaaca cgaataccgt caaaacgcgc 2590801 ctatacagag cattgaagct gatgcgcatt cagttgacga aggaggatct ttcttaatgg 2590861 ataagagatt acagcaatta agagaagaat ataaaaatgt tcagattcct aaagaattgg 2590921 atatcattgt tgaaaaagcc cttcagcaag aaccaaaaaa gaaaagaatc gttatgtggc 2590981 cgacatcagc agcaatcgct gcagctattt tattcactgc gcttgttaat atcaacccgg 2591041 acgccgctca ggctatgtca aagatccctg tcatcggcaa aatcgtcaaa gcgatcacct 2591101 ttattgaaat caaagaggaa aaagaccaat caagcattga tgtcaaaaca cctgctttgt 2591161 ccgggctttc taataaagag cttgaaaaca gcattaacga gaaatacttg aaagaaagcc 2591221 agcagctgta taaagagttt atacagtcca catccaaaaa caaaaaaggg catctcagca 2591281 tctacagtga ttacgagacg gtcacagaca cgccagattt actctctatc cggcgcaata 2591341 ttgaaacaac acaagcatct tcctacacac aaagccgtta tattacaatt gacaaaaaga 2591401 atgatatttt acttacatta aaaagcttat tcaaagatga gcgctatatc aaagtcatca 2591461 gtcaaaacat caaagaacaa atgaaacagc aaatgaagga agatccaaat aaaatatatt 2591521 ggctcactga cgaagatgca gaaccgttca aaacgattct tcctgatcag acgttttaca 2591581 ttactgaaga ccataaactt gtgatctcat ttgacgaata tgaagtcgcc cccggctata 2591641 tgggcgttac agagtttaca attccaaccg gcgtcatttc aaacttgctc gtgggagaac 2591701 gttatattcg ataaaataaa aacatccatc taagattatg gatgttttct ctcttctcta 2591761 ttcgaggtcg taaccccgct atcaaaaaca acgagaatat ttgcatacta ttggaggaat 2591821 acccatgtat cacaagacac agcatcatcg atacattcct ggacttgatg gccttcgggc 2591881 tttcgccgtc ctgtcagtta tcacttatca cctaaatttc aattgggcta acggtggttt 2591941 tatcggggtt gatatctttt ttgttttatc cggatatttg attacatcta ttctattacc 2592001 ggcatatgga aatgatatca atcttgattt tcgggatttt tgggtgcgcc gcattcggcg 2592061 gcttctcccg gcagcgtacc ttatgatctt ttccactgtt gtgtgggtcg tattgtttga 2592121 tcgagaacta ttgcacactg tacgtggaga tgcgatctct tctctctttt atatgagcaa 2592181 ttggtggttt atttttcaca agctatcata ttttgatagt ttcggttccc catcacctct 2592241 aaaaaacctt tggtcgctgg cgattgaaga acaattttat atcatatggc cgatgttttt 2592301 agttgttgga atgtacataa tgaaaagccg cgccagattg gctgcggtga tatcattgct 2592361 tgtgctttgt tcagccgtga tgatgagcgt actgtatgaa cctggcggag atccgagccg 2592421 cgtttactat ggcacagaca ctcgttcgtt tgaacttctc atcggatgtg ccttggcttt 2592481 ggtatggccg atgaaaaggc tgtcttccaa caggctgcca agcaaactga agcacacttt 2592541 gcacgccact gaatttttgg cattttgtat tttagtgttg tgtgtctatt tcacagatga 2592601 atacgagcct tttctttaca gaggcggaat gctattcatt agcgtgactg ccgcaatcct 2592661 tattgcatgt gtttgccatc cgagcagctt tttaggcaat ctgctttcat ggaggccgct 2592721 tcggtggctt ggaacgaggt cttacggaat ttatctttgg cactaccctg ttattgtgtt 2592781 aagcacgcca gttcaagaaa tcggaaaccc tgttttttgg catatcgtgc taaaggtcat 2592841 tgtgacatgt atacttgccg agctctccta ccattttatt gagaagccga tacggacaca 2592901 gggatttagg tcattttccc gccgtgtttt tatacataga atcaaggaat ggaaaacgac 2592961 atctgtcatc agcaaaatgt caattggttt cattattttc gctatactta tttttgcagg 2593021 cgggctgtca gggctagccg gcgagcaaaa gcaccctacc aaatggacct atagctcaca 2593081 agaaacaaat gctgacacca gccaggcttc tggggataaa aagaacgctg cagcagataa 2593141 aaaacacaat cctgaacaaa agacaacaga ttccaatcag ggtcaaaagg aaaacaaaga 2593201 tagtgggcaa gagactcata aaaagaaaga cacgcaatcc caacagttga aaaaaccagc 2593261 agacactgcg aaagaagttt tagctatagg agattccgtc atgcttgata tttcttcaca 2593321 cctgcgtcag tcattttcaa atgtgacgat tgatggaaag gtagggagac aaatgtctca 2593381 agctttggaa ctcgcaaggg aatacaagtc ttttaatcag ccgaacaagg ctgtcatcat 2593441 tgagcttgga accaatggct attttacaaa cagccaaatc gaacaactgc ttcaatcttt 2593501 ctcaaaagct catatttatc ttgtcaatac acgggttccc cgccaatggg aaagcaaggt 2593561 aaatgaatct ttgcagcaac aggcccacgc acatcaaaat gttacgttag ttgactggca 2593621 tacagaagct cttcagcatc cggaatattt tacccctgat ggtgttcact tggttcctaa 2593681 aggggcaaaa actttgactg ctcttattgt tcaggcgatg aaatcgtaaa aaagagatcc 2593741 tatacagatc acttttttac tttagtttct gatcgttgat tatgtcttct ttcagcaagg 2593801 cagcccttat gtttacatgc cgtttacgta agggtaagcc aaaattgaat ggagggatga 2593861 taatgaaagg aaatgaagaa catgacatcc aaaaagagtt gaaacgatat gagctttttt 2593921 tcaaaaaacg atataaggtt ctttatacag taaacgattt tatcatcggt gctatgtttc 2593981 tcgttggaag ttttttcttt ttttatgacc ggttaatgtc ggcagggata tggctgtttg 2594041 cgatcggaag tttgctgctg ttaatcaggc cgaccattcg gctgattcat gactttcatt 2594101 accgtaagca tgtggaacag caattcaagc atcaatcttc aacagatgac tgatcttaag 2594161 gaataagaaa gaacaaaatg ccaaaagcct gagtcgaaaa tcaaaaacaa gactttcaga 2594221 ctatttattt ttaaaaacaa ggtaaaaaga actaaacttt tgcctctgca tgccgatatg 2594281 aataataagg ccggcgcgat actccctata acatcctttt cagtagattt cattatcgtg 2594341 ccggttttct catatgcaaa gcaatcccgc caatcagatt ggcgggattt tatattttac 2594401 attcctgtcc aaacgtcttt cacataacgt ctttgatctt gcagcttttg cagccataca 2594461 gctgattctt cctgacttgc tgctttttca gcttcatatg ccaatcgcaa agttctctct 2594521 acatcaggag ccatttgcga tccatcaccg catacgtaaa tatgagcccc tttttcaatg 2594581 agtgtcatca atttctgcgt atcttgcttg agcaagtgct ggacatatcc ttttggttcg 2594641 ttttcgacgc gcgagtagca tcggcggatt gtgaccaaac cgtcctgttc cgcttgatcc 2594701 agctcttctc tgtaaaggtc gtcatggtcc gggcggcggc agccgaagta taaaagtgct 2594761 tcaccaaggg tgcttccttc cttcttcaaa accgatcttg cctgaataaa gcctctgaat 2594821 ggcgcaattc ctgtgcccgg cccgaccata atcataggcg tttcaggatc attcggcatc 2594881 tgaaatccgg actgcggcgt acgaatgaag caagctgctg catcacctgt attcaattct 2594941 gctaaataat tagaggcgac accccggtat tcacctcggc cgctccatgc tgaggctttc 2595001 acaactccta ccgtcatgct cacgatattt gcatgaactt tcggtgagct tgaaatggaa 2595061 tagtatctcg gttttagtga tggcaaaagt gctaaaaacc gttcaaacgg catttcgcaa 2595121 gcaggataat cctctaaaaa atcaagcatg gtaagacgtt ttgcaagtac ctgctctttg 2595181 taaatgccat catctgaaac gagctgttcc agctcttttt gatgcggcgg acaaactgta 2595241 taagaggcca gctcccgaag ctgaagcctt gatgccggtt cctgcagctc tacataggac 2595301 gacaataaat ccactacttt gattggccga tccatcggca gatgagccat atgagcgctt 2595361 ccgcttactt ttatcacatg attggactgc aaaccgaatc ggctgagaac ccgctgaaca 2595421 agctccctgc tgttctttgg caggattccg atatgatcgc cttctttata tgttttacca 2595481 gccggaattt ccaattcaat atggcgggtt gaacgcgtgc tggcagctgt ctggagttct 2595541 cgattctcta acacaatccc ttcaaacgcg ccatatgctt tagcaaccgg cgtttccgtc 2595601 gcttcactga gaaaagtaat cgataatgaa ggcctgtctt ctttctgggc tatttcgtta 2595661 atatcaaatg cgtccatcgt ttccttccag aagcggtttt cccaagactc gcggtggctt 2595721 tcaaaatcat cggcggcgtc accttcccca atcgctgtta aacgcgatgc cccctttgct 2595781 ttcatcatgt catcaatcag gcggggaatc cgctgatacg tgctggccca gctccggttt 2595841 ccgcagccga ataccgcata ggaaacacct ttcaattggc cttcctcaag ctctttcagc 2595901 cactctacaa atccggcagc attatcaggc ggcgccccat tataagaagc cgttacaatg 2595961 acgactgccc cttcttcagg gagcttgccg atataatcat caagcggagc cgtttcagct 2596021 gtaaagccca tctggcggcc ttgagcagcc agttcaccgg ctattccctc agctgtccca 2596081 agatttgaac caaaaagaac aagtaaaggt gtgccgtgtt taggtttggt ttcttttggc 2596141 tttgtttctg ctttgatgtc tgcctgttct tttctctgta cattgattgc cgctgttttt 2596201 cgcggtttca cagtaatttt aaaatcatcc ggcttgatcg ttaatgcttc tttgattttt 2596261 agttcgtagc cagtatggtt tatcaattca aaatgcttta atacaagacc gagaaccatt 2596321 gtcgcttctt gaagagcaaa ctgcatgcca atacaagcgc gctgtccgtt tccaaacggc 2596381 ttatacgcat ggtgagggat acttgaagga tcctcaaacc gttccggacg gaaatcttcc 2596441 gcatccggtc cccaagcgtt ttgatcccgg tgcagttttg gaattaaaac agtgactggc 2596501 tgccctttgc tgatcggata ttccccgcct agaacagtat cctccttcgc atatagagaa 2596561 aaagccggag ctgttggata cagtctgagg gtttcattta aaaccatccg aatgtatttg 2596621 agctgctgga tttgtttata ttcaggcgtg tcatccgtta acacgcgatc cgcttcctcc 2596681 tgagcttttt tcagtttttc cggatgtgta agcagacaat aaatcgcaaa ggatagcaac 2596741 ccgcttgttg tctcatgtcc agcaattaaa aatgtgatga tttggtatcg aatgttttcg 2596801 tcatccagcg tttcacccgt tactggatct ttggcataaa gcatgagaga caagagatcc 2596861 ttaatgtttt catccggatt cgcctttcgc tccgctatca ttctatcaac cagggagttc 2596921 atgacttcta tatccttttg gaactgcagc ttcgttttca ccatcatttt atcttgcagg 2596981 cccagtcttt tcgattgatt catcgcctct tttaaggcac ggagcatact ggtgataaac 2597041 ggatgctgtg aatcacggta aaagctgttg aatcgatagt taaacccgca taacccaatc 2597101 gtatcaagcg tcagacgtgt catatcgtcc gctacatcaa tttcttcatt agggtttaac 2597161 cggctccact tttgaatcag ctgggttgcg atatccagca tcatagaatg atagcctttc 2597221 atcgcttttt gactaaaact cggcagcaaa atgcggtggg ctttttgcca gttcggttcg 2597281 tgcgtccagc ttgtaaataa gccatctccc ccgaactcac gcaccttttg caagcctttg 2597341 ccaaggttct tgtcaaagcg tttttcatca cacacttcag ccacaagatt gtggccggac 2597401 acaaaaacac tggatactcc cggaaaatca aaacggaaaa tcggtcccaa ttcatcagct 2597461 atccgccata aggattgaga aagctgttct ttttccagat gcggaagatt ttttaaaggt 2597521 ccgtatgttt tgggctgagg tattgcgctt gcctgtttca ttaacatctc cctttcctat 2597581 ttttgtgatg aatgaagctt aatggcgtcc cagcagcatt gttccaattc agtaattaaa 2597641 tcagtgtcca tctctatatc acctgtttga acgagctgat atatcttgag aaacgcccct 2597701 aatacaatcg caattaacac attagagggc aggctgcgaa tcacgccttc cgcttttccc 2597761 ttattaaaat agtcatcaag catttgagtc agattttcta tcattttttt gcttgtatga 2597821 tttaagtaat gagcgtcttt tttggtttca agaaaaaaaa gcgcatagtc gctctctttc 2597881 gtaaactgaa cgagacagca aaatacgtgg tgaaagcctt ctctgacagg caattctgaa 2597941 acgtcttgct tcagtttttc cgtaaatcgc tggatgcttt cttgaaacag tacgttaacg 2598001 agtgtttctt tgctgtcaaa ataacgatag atcgttcctg tccctacatg agcacgttca 2598061 gctatcatag gaatagtggt agcgtcaaaa cccctttccg taaaaagtga gactgacgct 2598121 ttcataatca tgtcgtattt actgctggat gcggatatca tgtaatctga caacctccga 2598181 ttcgtttacg gaatgaatat tcattccttt tgttcacaaa gaatgtctgc cctgtctgat 2598241 atcacctctt tgttctttct tctgttataa gtttatatga aaaaaacttt ttttaatata 2598301 aagtatatgc aaaaaataaa aaattaagaa aatataccca aatcctaata cgaggatctt 2598361 ggatatattt cccgagaaat tttttattta acagccacaa tacatagaca ggaagcacgc 2598421 ctgataacag aaagatccct gaaatgctgg tctttcagca gttgaatata cgttttctct 2598481 ttttcaccgg tatttgtgtc aatactgata taaaaccggc cgtcaatttg aagcaccctg 2598541 taaatttctc ttaatgcaag cctaatatcg gtgcagcttt gaaccgtatg taaagaaaag 2598601 actttattaa aggtacggtc atcaaaggga atgtcctctg gatagccatg aaaaacctcc 2598661 ccgttcccca tgttctttcg attcgcacgt gatatctgtc ttacctttcg ttttgaagga 2598721 tcaatgcttt ttaggctacc cttttttagt ttcttggtta tgcttttaaa gacagtgccg 2598781 tttccaattc caatttctaa aattctgtca ttttcttgta tatctataga gtcaatcatc 2598841 atatgctcaa ttgttttggt tagcttatat ttccgagaaa ataatttcca aaaatccgat 2598901 cgtttataga gtctattttc tagcatttta aacacctgct tttggtttcc tatgtttatt 2598961 tattatctta aaaaaataaa catcatcttc atttctaaaa gtgaaggaag gtaccaacta 2599021 gacggcaatg tattgaaaaa tgtttcaata gaactaaact ttttcatttt tttccgaaaa 2599081 aaaagcagaa aacataatgt tttctgccct ctttctaatg ccaatgataa gggaatacat 2599141 acagcctttg ctgctgcatt gccatcagcc tctgctgtcg gaatggattt ccataaccat 2599201 gtttgaagga atgcggcatg gacgcataac catggccaat cgacggcagt cttttttgat 2599261 aatcgttcat catgccatca cctgcctcac aataacgttg atttactata tgcaggcgcg 2599321 cattttcttg acagctattt cgctaaactt ggtccttctc cattgtataa tgcatcaata 2599381 gttccattct aagcatatgc cattccccct tcagtttttt tcgttgcttt tagcgccagt 2599441 ttgttaaata aagatgcttt aactgagact ctttcatttc atcataaatt tgttcaatct 2599501 gctgttctcg ttcgaattct tccaggcttt taaaccgttt tttaatcgtt aacgttaaaa 2599561 agaataggtt aatcgtcata tcgctcaccc cctttcaaag tccgcatcaa gcgaaataac 2599621 ccgcggcaca acccttctgc cgcgggcaaa taaaaaccgc agacaaaaga agacaccaat 2599681 gcctctactg cctgcgggga gttgcgtatg tccgactatt ccgaatttaa tgcgtgcgat 2599741 aagcatcggt taaggaagga cacgaactct tccacaggct gaataaacca tgaactttta 2599801 catgtgtatc acgtacaggt tgacgtcgtt gtctcattgt cattttggtt cagcctcctt 2599861 tgcttttttc ttactttgta agtatatcca ccaaattcca ttttgtaaac atctttttct 2599921 aaaaatggac ggaaattgtg caaatcatcg aatggatttg cccgttggtc atgacacctg 2599981 cttcatttct tttctggagc ggtctttctt atgatatgca ataaaataaa tgagaccgac 2600041 aaatacagct ccgccgatga cattaccgat aaaagccgga atgatgtttc cgatgaactg 2600101 cccccacgtg aatgagcctg caaaaatggc agcaggaatc acaaacatgt tggcgacaac 2600161 gtgctgaaat ccgatagcca caaaagccat gattgggaac cagatgccaa ggatttttcc 2600221 tgctgcgtct tgggcgccga aagaaagcca cactgcaaga catacaagcc agttacagcc 2600281 gatggcggaa atgagaacct tgccaaagct catatcaagc tttccttggg caacggcaat 2600341 cgttttttct aaataaggac ctgtttcagt caatccaacc aaatgcccga aaaagtaagc 2600401 aacaaacaat gcgccgatta agttcataat tgtgacgatt ccccagttaa tcgctaactc 2600461 ttttactgat atttttctcg aaaataacgc catcgcaact gacatcatat tgcctgtgat 2600521 cagttcagcg ccagcgagaa cgacaaggat caggccgact ggaaatactg ctgcaccaat 2600581 caaactggac aggctccccc attctttcgg aagatcgcca attaccctga tatcaagcaa 2600641 atacccaagc gcgataaatg caccgcctaa aaaccccagc acaagcagtg acggcagcgg 2600701 gagctttatt tttttcatcc ctgcttcaat tgctgcttcc gctatttcat ccggttttcg 2600761 aaaagccata ataaaacgcc tccattactt cttcttttct cacagttatg caagaaaggc 2600821 aataaaaaag gcagcactca aataacctgt gtcaaaccag gcgtttgaat gctgcctaac 2600881 ttgtatgcat acccatacaa caatatcaag cagtatataa gatattgaaa gagaatatat 2600941 acagttcgtg catacattcc attgctttag ccttctataa ctgtagcaac atcatatcaa 2601001 atgtgacaaa tttgtgtcaa tgacaaatat actagctttg cagagcttct ttttgctcat 2601061 ctatttttcg gtcaaaaaca aatacagata cagcgatgtt ttcctcaatt ttaatatcag 2601121 aaaacaaatg gactagctta gctcccataa gttcctccat tccttccggt gtttgtttgg 2601181 aataaaggtc ttgaattagg cttgtccggg ccgcatgtac catctctctt ccttcaggcg 2601241 tgcgggcaat aaactgctcg cttgcactca gatttccgta tagtgttgaa actgccatgt 2601301 tttctacaaa tacagtatga attctctcag gcccttttcc gaacaattct ttgcgaagtt 2601361 ttcgaataat atcattgaat tcatgaattt ttttagacat gctgattacc ccttccgata 2601421 ttgccttata aaggcttttc ccggttcccc tcaggacatt tcacttggtt aaaattttcc 2601481 tgccatattg tattataata aatatcacat tataataaaa gcagtgttga tggatttgta 2601541 ataggatctt gttatgagtc tatcgtttta taaaaatcaa ggattggtct gttagtaaga 2601601 cttgctagtg aactattccg ccatgtgtgt ttacaccttc ttagaattaa gggcaggtgt 2601661 atctatacat ggcttttttt gacttcttga aagaaagatg gaggggaata tgaatatgat 2601721 ggacgttaag tcgatcagtg tccgtgtaga cggaacagaa attcaagcac gagcaggggc 2601781 cacaatttta gatattttaa atgaaaacgg aattgagtac ccgcagattt gccacgtacc 2601841 agaggttgac ccgattcaaa cttgtgatac ttgcatagta gaggcaaacg gcaagctggt 2601901 tcgttcatgc gcgacggttg cagaaaacgg gatgtctatt gatctttcag gaaatcgagt 2601961 gaaagaagcg caaaccgaag cgatggaccg ccttcttgaa aatcatttgc tgtattgtac 2602021 agtttgcgat aacaacaatg gaaactgtac gctgcataat acagcggaaa tgatggggat 2602081 cgagcatcaa aaatacccat acacgccaaa agaagatcct tcttgcgcgg ttgatatgtc 2602141 tcatcctttt taccgctatg atccaaacca atgtattgcc tgcggccagt gtgttgaggt 2602201 ctgtcaaaac cttcaggtaa atgaaacact ctcaatcgac tgggaacgcg aacgccctcg 2602261 cgtcatttgg gatgagggag ttccgatcaa tgaatcttcc tgtgtcagct gcggtcagtg 2602321 tgtaacagta tgtccatgta atgcactgat ggaaaaatca atgctcgggc aggctggttt 2602381 tatgacaggc attaaagagg acgtcatgga accgatgatt gatctcgtga aaaatgttga 2602441 accggggtat ggcagcattt ttgccatttc tgaagtcgaa gcggcaatgc gtgaaacgag 2602501 aacgaaaaaa acgaaaactg tatgtacgtt ctgcggtgtc ggatgttcat ttgaagtatg 2602561 gacaaaagga cgggatattt taaagatcca gcctgtttct gatgctccgg ttaacgcaat 2602621 ttccacatgt gtcaaaggga aattcggctg ggattttgtc aattcaaaag agcggatcac 2602681 aaagccttta atccgtaaaa acggagcctt tgtggaatct tcttgggaag aagccctcga 2602741 tcttgtcgca agcagattag gatcaattaa agagcagtac ggtaaaggct ctgtagggtt 2602801 tatttcttct tctaaaatta cgaatgaaga aaactacgtc attcaaaaac tagcgcgtca 2602861 ggtatttgaa acaaacaacg tcgataactg ctcacgctac tgccagtctc ctgctacaga 2602921 cggattgttc cgcactgtcg gcatgggcgg tgacgccggc acgattaaag atattgccaa 2602981 agcaggcctg gtcatcattg tcggtgccaa tccggcggaa ggacacccag tgctcgcaac 2603041 acgcgtcaaa cgggcacaca agctccacgg tcaaaaactg attgttgctg acctgcgtaa 2603101 aaatgagatg gctgagcgat ctgatctgtt catcagccct aaacaaggca cagaccaagt 2603161 ttggctgatg gctgttacga aatatatgat cgaccaaggc tggcacgatc aggcgtttat 2603221 tgatgagaac gtcaattact ttgaagatta taaagaaacc cttaaaacgt atacgcttga 2603281 ttatgcagaa cgcatcacag gcctttcaaa agaaaacatc attcaaattg ctgaaatgat 2603341 tcgtgatgct gacggcactt gtgtcctttg gggaatgggt gtcacacaaa atacaggcgg 2603401 ttctgataca tcagcagcca tttcaaacct gcttctcgct acgggcaact atcgccgtcc 2603461 aggtgccggc gcttatcctc tgcgcggaca caataacgtg caaggcgcat gtgatatggg 2603521 aacattgcct ggctggctgc cgggatatca gcatattaca gatgacaaag cacgcgctaa 2603581 atttgaagag gcatatggtg tcgagattga tggaaagcct ggtttagata atattcaaat 2603641 gcttcatgcc attgaagaag gaaaaatgaa agctatgtat cttgtcggtg aggatatggc 2603701 actggtcgat tcaaacgcga accatgtgca tgatatttta tcaagccttg atttcttcgt 2603761 ggtacaggac atcttcctgt caagaacagc tcaatatgct gatgtcgtct tgccggccac 2603821 tccttcactt gaaaaagacg gaacatttac caacacagaa cgccgtgtcc agcgattgta 2603881 tcaggcgctt ccgacgcttg gtgacgcaaa accggactgg tggattattc aagaggtggc 2603941 aaaccgttta ggagcgaatt ggaattacag ccatccaagt gacattttct ctgaaatggc 2604001 gagtctttct cctctgtttg ccaaagcaag ctatgaggtg cttgaaggct ggaacagctt 2604061 cctatggggc agcttcacag gtgaaagcac accgcttctg tatgaagacg gatttaattt 2604121 ccctgacaaa aaagcccgct ttgccctttc tgattggacc gagccagcgg catttccgga 2604181 ggaatatgac cttcatatca ataacggccg gatgctggag catttccacg aaggaaacat 2604241 gacaaataaa tcgaaaggca tccaagcgaa agtgccgaat gtattcgttg agatctcacc 2604301 tgagcttgca caagagcgag gtgtttgtga cggttcgctt gtacggctcg tttctccgtt 2604361 cggagcagtc aaattgaacg cgctgatcac agaccgggta cggaaaaatg aactctattt 2604421 gccaatgaac tcgacagaca aggagtcagc gattaacttc ttgacgggcc ctgcagctga 2604481 taaacggacg aacacgcctg cttataaaca gacaaaggtc cgcatggaag tgcttggcgg 2604541 ctgtgaaaca gcgccgcttc caaaaacaaa tccgcgcaac aaaaaacggc atccgcaaaa 2604601 cggagtcgaa gcagaaagaa aatggaaccg ccctggctat gtacatctga ctgattaaac 2604661 gataggagga aaacgaatgg ccactccgat tacgacgatc aaaaaagaaa caaaaacagc 2604721 tgagcaaatt aagcttgaaa aaatagaaga actgaaagag ctgctggcgg aaaatgagga 2604781 cgccgtctct aaaacgatga cgttaatgaa tgaactcaat gatcttggaa tttttgatgc 2604841 ggcaacaagc atgctcagag cgaaggaaga cattgccaag attgcgcttg gccaagtttc 2604901 ccgcgagcct gtcaccaacc tcatcaacac gatgatggcc gccggaggcg cattgacaaa 2604961 agccgatcct gagtttacag caaagctttt agaaagcgta atggctggga ctgaacaggc 2605021 acaaagcttt ttaaaagaag acaagaaagt cgggattctc gacctgttaa aagcaatgaa 2605081 cgatcctgac atcaacagag ccgtcgggtt cggccttcag tttttaaaag gcatgggaaa 2605141 agaacttcga gaacaataac agaaaaacag ccatctctga tgatggctgt ttttttattc 2605201 gtcggcttct tccagacgct tcttgtaaat aagtgaacgg tcagcgcaaa agaaggcacc 2605261 ggctaaaaat acgcaatccg ctaaaaacat cgtcgatttc tggcctaatg ttaagccttg 2605321 atcagggaga actgcgccta tatataaaaa agtgctgact gcaagcaatg taaaagcaaa 2605381 atgcttgtag tcttctttta aagatttcat tctatttttg ttcaaaagaa tcacctgcca 2605441 gattcatagt atacgactat tataatataa tccggcggct tacagagaaa gtaattctat 2605501 ccatttgtta tatattttca agcgcttggc cgatatcttc caacaagtct tccgcatctt 2605561 caattcctac agaaattctg atcaagccgt ccgtaatgcc gagctcaagc cggcgttctc 2605621 tcggaataga ggcatgtgtc attcttgcag gaacagaaat taagctttca accgccccca 2605681 ggctttcagc aatggtaaac agtttcagat ttcctaaaaa cgcatcaacc cgttcttcac 2605741 tgccaatatc aaaggagatc atgccgccga agcccgctcc ttgcgttttt gcaagctcat 2605801 gtccgggatg atttgaagaa ccagggtaat ataacgtttg gacagcaggg tgattctcaa 2605861 gaaagcttgc gattttccgc gcattttgat cgatcgcttc cattctgagt cccaacgttt 2605921 tgattcctct cattaacagc caggaatctt gagggccgag cacgccgcct gtggagtttt 2605981 gcacaaaatg cagctcttct ccaagctctt tcgaagctgt cacaactaaa cctccgacga 2606041 catcactgtg tccgccaaga tattttgtcg cactgtgcag tacgatatca gcgcctaaag 2606101 taagcggctg ttgaaaataa ggagtattaa aggtattgtc tacgataagc agaacacccg 2606161 ctttttttgc gatatcagcc atgagcgtca ggtcggtgat tttgagcaac gggtttgtcg 2606221 gtgtttcaat ataaattgct tttgtattag ggcgaatcgc tttttcaact tcttccctgc 2606281 tgctcgtatc aacaaatgtt gattcaatgc caagacggtt aagcaccttt gtcatcacgc 2606341 gatatgttcc gccgtacaca tcatcagtca acacgacatg atctccgctg ttaaacagca 2606401 tcataaccgc tgtaatggca gccattcctg agctgaacgc atagcctgct tccccgcttt 2606461 ccagttctgt cacaagtgct tcgagagcgg ttcgagtcgg attggccgtt cttgaatact 2606521 cgtagcctgt atgctgccct gctttcggct gcttgtacgt gcttacttga taaatcggca 2606581 cggaaactgc gcctgttttc tcatcacctg tgattccgcc atgtatcatc aatgtttttt 2606641 tcttcatatc agatgcctcc ttcgtatatt tgtttgctga tatatcgatc gctgctgtca 2606701 ggaaatactg tgacaatgtt agttccagcg gatgcttttt tcgcttcctc caatgccgca 2606761 taaagcgctg cacctgaaga gcttccgatc agcaggcctt ctttttctgc cgcttctttc 2606821 acaagtctaa acgcattctc atctgttacg gtgtagatct cgtcaaaatg gctcttatcc 2606881 atataatcgg ggataaactc catgccgatg ccctctgttt tatgagcgtg gggctctcct 2606941 ccgtttaaaa tcgagcccac cggttcaaca atcaccgttt tgactgctgg atttttttct 2607001 tttaagaagg aagctgtccc tgcgaatgtg cctcctgatc ctgcccctgc gacaaatgta 2607061 tgaatattcc cgtcaagcgc ttcccacatt tcaggtccaa gcgtcttata gtaagtcgat 2607121 ggatttactc ggtttttaaa ttgcaaaacg caataagaat tttcaatttc agtctccagc 2607181 tgaatggctt tttgaatggc tccctgcatt ccgtcttgac gcggtgtatg aatgattgat 2607241 gcgccaagcg cttgcataat ttgctgtttc tctctgctga aatgttcagg gacacagaaa 2607301 atcgctttca gcccatattt tctggcactt aacgcaaggc cgatccctgt attgcctgcc 2607361 gtagcttcta taatcactcc gccgggtttc actttgcctg aatcgagcgc gtcacgaatc 2607421 agcatatctc ccagtctgtc tttgatgctt ccccctggat tcatcatttc aagcttggca 2607481 tacaccgcga ctccttctgg aacatcaaag ttcttcaagc ggagaagcgg tgtattccca 2607541 atcagctcgg taatgtccgt aatcactgtc atatatgtcc tcctccttaa tagaggttgt 2607601 ttttagagaa aaacggagga gaacgttctc cccgttttaa tgaattcgtt tgatcacctt 2607661 taacacaagc tctgttgaat gaacagccgc ctgctctaaa aattggtcaa atgaaacatg 2607721 tgattctttg cctgcgatat ctgataacgc tctgatgacg acaaacggcg ttttaaattg 2607781 atggcatact tgagccactg ccgcagcctc catttcaacc gcgtacagat cagaaaatct 2607841 cgcacgcacc tcttcaaccc gcttcggatc gttcatgaaa gaatcgcctg ttgcaatcgt 2607901 tccttttgca acctgaatgc cgtcgagttc agataccgct tcttcagtga tgctgatcag 2607961 cttttcatcc gccgcataag cagccggaag acccggcact tggccgtatt catagtcaaa 2608021 agccgttacg tctacatcat ggtggcgaac gtcagtggaa atgacgacat cccctacatt 2608081 caatgtatga tgaaatccgc cggctgagcc tgtgttaatg acataatcag gcttgtaacg 2608141 gtcaagcaga agcgtcgtgc tgatagcagc atttactttt ccaattcctg attttaaaag 2608201 aatcacttca gttccttcat attcgcctgt tgtaaattca cagtgtgcga tcgtttctgt 2608261 ttttgcattt tcaagtttgt ttcttaagat ggtaacttcc tcttccattg ctccgatgac 2608321 tgctagtctc atctattcac attcccttca ctttaccgtt tgatcgcctc cattatccac 2608381 acgaagtcgt tttgctgagt gaatcggact gcaaaacctt cagctgtaaa catttctttc 2608441 aacgcatcca atgtaggata atgctctgtc tctaaatcat ttgcaagctg ataaaagcct 2608501 tgagaacggg ctttatcgat agcctgttga tacgcttgcg cattttcaaa gacggtatcg 2608561 gcaaacacta ttttatcatg caagtgaagg tatttgccat attgctttat ggcagcccgc 2608621 ttttcttcgt cagtcaaatg atgaaaagca tatgaactga caatcgtatc agcctgaaat 2608681 ggcggctcag ggaatgtcag gaagtctcca tcaacgattt ccgtcctgcc tgagagcttg 2608741 tcagaagcca gtttacgcat tgctggagaa ggttcgattc caaatacagt tttgcctgca 2608801 tcgagcagct tagctgtcaa attcccggtc cccgggccaa attctaacac atgcgttcca 2608861 gattttctga cgatggcatc aaggatatga tcgtagcctc tgaacgcttc tttatactga 2608921 atatctaaac cttgtactgt ttgatcataa gttgctgccc aatcttcaaa gagagggata 2608981 aattcacggc ccatatttgt cacactccat atttaataat tcctataagt atactatgga 2609041 ttaatgatgg aacagttcct ataataccac atattctgaa aagcaggtac taaaacactt 2609101 tgtgtatttt atgccatctc atattgcgca ttgaccgcaa aaaagcttat acttcatatg 2609161 acttgtgaaa gctggagggt caagacatga attttcaatt agatctgatt aaagacaaag 2609221 tggaattttt tgaagcggct tcattgcagg agcttgaaaa gaaaatcaat acacaaattg 2609281 aaaacaataa agccatcatg ctccgggtga aatctgtttc acaccaaact cttgtggcag 2609341 aaggaagaat attgtacagc gcggtggttc atttctcagc tgaagcctaa aacaaaagca 2609401 gccggtttta acccggctgc ttttgtttat tttagctttt ctacttttgt cggcttccag 2609461 cctttttcat cgacccatgt aatcgtgact tgatatttat tcccagtcgc cttgtccaaa 2609521 atcttgcctt tggcatcctg agggctgccg ttatttccaa gccagagcac cgtcatgtta 2609581 tctgttgaga caccagttgc gtacgaaatg gctttcagca tctcagccca gtcttgtgag 2609641 cttgaatcat aagtagcggc atgctcgcca gtctgctcag ttccgactgc tttccagtca 2609701 ggattttcat acgttttttc cacatcgctc gatgagccgc cttctgttac ttttgcatct 2609761 ttaagcccgt caccggctga atctgagctt gaatctgaat cagagtcatc ttttttagaa 2609821 gaagaatcat cttttttgga atcagagtca gaagacttct cagaatcctt ttcgctgtca 2609881 gatgtatctt tcttgctgtc ttttatatcc tcatccgatt tcttttccgt ctttcctgaa 2609941 gccggagatt cctgtttttg cgccgtttca gaatccttgc tgacatcttt gctagaagga 2610001 ctgttaatga agagattcgc tgctactacg acaattagta tggatacgat tgcgattaaa 2610061 atgttaagca ctaaattggc ttttctgcgt ttatcacgat tttcataacg agattgatta 2610121 ttgctcaata attctgcact cctttatccc tcttggctca gcatatattt taacatgtgc 2610181 tgagaagttg ttctatttct gattgatttc aatttcgtgt acttttttaa caatatcata 2610241 aaacaccgaa tttgtcagag ccttatctcc cggtgtatcc atgtgtaaaa caactagagc 2610301 gtatttcggc ttatccgcgg gaaaatatcc ggcaaaccat ttttcgtaga gcgtttcctt 2610361 ctcttttgaa agcttgcctg tctgggctgt gcccgacttc cctgctacag tatacggaag 2610421 atcttgaaac cttctgcccg ttccggaagg agattctact acccgccgca gtattttttg 2610481 aagctgctgt gacgtatatt tgtctatcgt ttcccctttg agcttctgat ctttaaacgt 2610541 aacgagcgtt gtgccgttct tatactcaat ttgttcggca attttcacct gccgtttttc 2610601 tccgccgcgg gcgattgtcg ccatcatatt ggctacctcc agcggcgtta cctttacatt 2610661 tttctgcccg attgctgttt gcgcaatggc ttttttgact gatttgtctt tttcatcccc 2610721 ccaaatcacg ccgctttttt cgttatacag ctggcggaaa tcggtttcgt ggtacagttt 2610781 tccctcccag cctgcccgat cagtgagagc cagcttctcg gacatatctt caataaccga 2610841 gctgtctttt ttcattaatt gttctgcaag actcgtaaat gtgtaattac agctttgggc 2610901 aaaactttca tcaaaagaca aggtgccttt gtcgtccccc ggttccccgt acaggtttaa 2610961 attgcaatta aaggtttgac taggcttcac catattattt tcgattgcag ctgcggcaat 2611021 gactgtttta aaaactgatc cgggatagat tggcgtcagc atataatttt gaagtgtgtt 2611081 ttgccgggac acgtctgcat ctggtttgct tacaattccc agaacactgc tattttcgat 2611141 gtccagcagc acagctcctc cctttttcag cccctgttca tccaatacct cctccatcgc 2611201 tttttgaatg ctttgatcga tcgttgtttt gatctggagc ggataaaatg tattggcttc 2611261 agctgtatat ttgacgtcca tgccaaacaa agggtttcct tttccgtcca catgatataa 2611321 aagctttgtg tcttgttccg gaagcaaaaa ctcgtcaaat gtccgttcta aaccggttgt 2611381 tccgatttct gttgtaatcg gaaggctctc cttgtcagga tatttcttgc gaagcagcgc 2611441 cggatcttgg ttcgtgctcc ctatcgtatg tgaagcaagg ctgggcttgt cttcattctc 2611501 catatatacg ccgtaaatgc cgggatattt caaagaattg atttttgtga tagattgttt 2611561 tgaaagtgtt ttgattttct tttgctgcaa aatgaccggt ttttttgcct gacctagtgt 2611621 ctggcgcaaa tcatcttcag acatgccgag gatgtccgca acttttttga tcggccaatc 2611681 ctgcgtcagc agaaaaggga acaaaacaac cgcaggctcg ctttgtcctg tcagcgcccg 2611741 cccgtttcga tctaaaaaag agcctcttcc atctgaaatg agcacttcct ccgtccgctg 2611801 tttcacactt tcttgaatca aattaatttt ctttttagaa aatgattctg tgaaaaacag 2611861 ctggatttct gcaagtctca gcagaagcag aaaaaataca atcaaaaaag cgatgactgc 2611921 cagcttcatt cgtttcgata tcttcataaa aaaacacctc acccacattg tggacgaggt 2611981 gtttcgctgc taaacagata ttatgaaatt ttcacaattt tcacgagcat ttctccgccc 2612041 ggtgtttgta ctgtgacttc ttcatctact tttttgccca agaggctttt tgcgatcggt 2612101 gaatcgtttg agattttccc ttcaaacggg tcagcttccg cgcttccgac gatcgtatat 2612161 gattcttcat caccgtcagg cagttcgacg aaagtgacgg ttttacccaa accgacaacg 2612221 ttagagccgc cgtcatcttc aatgattttc gcattgcgaa tcatattttc aagagtcgtc 2612281 acgcggccct ctacaaatgc ctgctcttct ttcgctgaat cgtattcaga gttctcggaa 2612341 aggtctccga agcttctcgc aattttgatt cgctctacta cttcttttcg tttaaccgtt 2612401 ttcaaatatt ctaattcttg ttcaagtttt tgttttcctt ctgcagtcat aggaaaaact 2612461 ttctcttgtg ccatgtccct tcactccttc tggttgtccc tcaacatctt cgattatgta 2612521 tgagagcata aactaaaaaa tacaagaatg agaacacagg gcagtcctcg ttcttctctc 2612581 ccatataggt actgtttatc ttaaactgaa tcgtgtcgtt ctgcaaatat ttcgcgttta 2612641 taaacaggga aagaagggaa ttcgcacatt cccttcctgc ctatacataa tatggtcaga 2612701 gttatttatg tctatgctat ggtattacaa aatcgcgttt tgttcaagaa tggtttgaat 2612761 ttttgtgacc atcagatcaa ttgcgacgtg attctgaccg ccttccggga taataatatc 2612821 agcgtatcgt ttcgtcggct cgacgaattg gttatgcatc ggacggacca ctgacacata 2612881 ttgttcaatg acagaatcaa tagagcgtcc gcgctcatta atatctctca taatccgtct 2612941 gatgatacgc aagtcagcgt ccgtatcaac ataaagcttg atatccatca gatcacgaag 2613001 ccttttgtct tcaagaacaa gaatgccttc aaggataata acatcctttg gctctacgtg 2613061 aaccgtttct tctgaacgtg tgtgaagctt atagtcataa atcggctttt caatcgggcg 2613121 gtaattcaat agatcttgaa tatgctcgat taaatagtca ttatcaaacg caagcggatg 2613181 atcatagttt gtgttcagcc tttcttcaaa cggaagatgg ctttggtctt tataataaag 2613241 gtcctgctgg atcattaaaa ttgagtgtcc tttaaactgt tcataaatgg accgtgtgac 2613301 actcgttttt cctgaaccgg aacctcctgc gattccaatg actactggat tcttacccat 2613361 gggctgttac ttcccctttc tcatcatgtt gctcggataa atctttttgt ctagtttgaa 2613421 tttgacaatt tgcaggggat ggcgggcagc atctagctca tttccgtctt cgtcccaaat 2613481 ggtttcaatc gtatgtgtaa agttttcgat ttctggaccg aaaaattcca cttcgtcgcc 2613541 ttttttgaag aaattgcgct gctgaagcgt gaccatttgt gtatcttcat cataattcag 2613601 cactaagccg acaaaatcat atgtcgtttt cttggcgtgt tcgccgaaca tttgctcttc 2613661 atagcctggc gttccttcaa agaaagctgt cgcagtgtcc ctgttggcgc acttatcaag 2613721 ctcttcaagc cattcttttt gaatcacaaa gttttctgga tcagcgcaat aagcatcgat 2613781 tactttgcgg tatacgctga caacagttgc tacatagtga atggatttca tgcggccttc 2613841 aatctttaag ctgtcgatcc ccatttcaat catttttgga atggattcaa tcagcttcaa 2613901 atctttcggg ctcatcgcaa atggtgcatc ttcttcacca tacaaagcaa cggcgttggc 2613961 accgtctgtt tggtagagat cataatccca gcggcatgac tggcagcagc ctccgcggtt 2614021 ggaatcccgc gctgtcatgt gattgctcag cacgcagcgg ccggaatatg caatacacat 2614081 tgcgccatga atgaaggatt cgatttcgat atctaccttt tctttcattt ctctgatttc 2614141 aagagcgcta gtttcacgtg ccagcacgac gcggtcgaga ccttcttcct tccagaactg 2614201 gacagccttc cagtttgaaa gagactgctg tgtgctcaag tgaacctcaa cattcggcgc 2614261 cactctgcgg catgtttcaa taataagcgg atctgccaca ataataccgg caacgttggc 2614321 gtctccaagc gcttttaaat agtcttcaag cccgtccatg ttttcattat gagcgaaaat 2614381 attcgttgtt acgtagatct tcgcgccata tttctttgcg aattcaacgc cttctgcaat 2614441 ttcttcgatc gtaaagttat cggcattcga gcgaagcccg tattcctgtc ccccgataaa 2614501 gaccgcgtcc gctccgtaat gaacagcgat tttcagcttt tcaagattac ccgcaggtgc 2614561 gagaagctcc ggctttttcg taatcacacg ctttccatta acgattgtgg atattttatc 2614621 atttacggca gtcatagctt aacctccttt tgattaataa accgtttcct tgaagaagaa 2614681 tccggtatca atttttctgt ttactggctg gatgctttca atgcgttcga tccagtcttc 2614741 ttttttcgct tcgtattcgt cacggttttc cacgcacaaa tcaattgctt ctctgtacat 2614801 tttggtgact tctattaggt attcaggcat tttcaaaaca ccatcgattt tgaaagaatc 2614861 aattccggca tctatcaatt cctcgagctc atcaatgatg cacacatcgt tcgggctcat 2614921 gatgtgagtg ccgttttcat cttcgaaaat cggatattta ttatcgcgtt ctttatcgtg 2614981 taaaaacatg cctgattctt ttttctttct ttcaatgtcc atgactttgc cctgatattc 2615041 aaaatagttt ccaatcaaag aacgcttcga ttggaacatg cacgtcattc catgcacctg 2615101 gatttcaatt tcgacttcag cattttcttt aatctcaaca atgctgtcca tgtttaattc 2615161 tctggcaagc acagaacgcg ccgcaccctt gcgtccccag tagttgcatg tataatagtt 2615221 ggtgcctgtc gtttctgtgc tccaatgaag cttcagatca ggcgcagatt cacgggcagc 2615281 catcagcacg gcaggatcgc cgaataccgc tgcatcgaca ccggcttctg ctaagaaagc 2615341 cagatattcg ccaagctcac ccactttatc attatggaaa attgcattta cagcaacgta 2615401 tacttttgcc ccttctttgt gagcaatctc tacggctttt gttacatctt cacgagaaaa 2615461 ttctccggct aatctcaagc cgtatctctg ttccccaact aaaaacgcag ttgccccagc 2615521 ctgtatgagc ggcaaaatgt ccgctgtact cgtcggcgtc actaagagct ctggtttttt 2615581 catgacgttc acctcttctt tttactaatc gcaagtccgt ccccgacagg aataatcgca 2615641 gtttgataat ccggatgatt catcagccaa tgattatatt catcaatttt ggctacaagc 2615701 ctgcgccttc tcttcggttc tattttgctg taatcctctg ccaccagacc tttaaacagc 2615761 acgttgtctg ttataatcac cccgtccggt gaaagcatcg gttcatataa atgaaaaaag 2615821 ttttgatact gaccttttgc agcgtcaata aaaatgacat cgtaaggcgc ggttacatga 2615881 acggcgtcgg ctaattcaag cgcatctccg taaaaaacat gaatccggtc atcaagctga 2615941 aattccttga tattgtttac cgcttcttca tgccgtttct cattgcgttc aattgtatat 2616001 atttcagcag acggcagttc cagagccatt cgaatggctg aataaccaat ggccgttccg 2616061 atttctagta tttttttcgg ctgtttcaca gacaaaattt gaagcagcac ctccatgccc 2616121 gctttttcca taatcgggac atgatgttct tctgcatatg cttcaagtct cttcacgtta 2616181 tccggccgag gctttaataa tgcttctata tagtcattta tttgttcata ccggtcagtc 2616241 actacaaaca gcctcccgtt ctaaaaagga gtgccccagt cttatgcgca ggacactctc 2616301 tgaatacatc atgatacatc ggtaaacaac ccgatatatt ttatcataaa accttgcgga 2616361 aagcgaacaa aaggagagct ttttgctctc cttttatttc tcattttttg aggaaatgta 2616421 tttttctttt gctttattat gctcttttag cgtttttgta aatacgacct caccatttga 2616481 tttggccaag aaatacagat agtccgtttt atccggatgc agcgctgctt cccatgatga 2616541 catgccggca ttggcaatcg gccctggcgt cagccctgtg tttttatacg tattgtatgg 2616601 tgaatcgatt tccagatcct tataaagaac ccgatcttta tgcttgcctg ccgcgtacag 2616661 gacggtcgga tctgtttgga gcggcatttt ctttttcagg cggttataaa agacgctcgc 2616721 aattttatgg cggtcggctt tttcagtcgc ttcttcttct atcaaagaag ccattgtcag 2616781 cagcttatgc acagaaactt tgtttttctt catttctgat ttatatgttt ccacataaga 2616841 atttgtctgc ttaatcattg ccttgataat gtcttcaagt gatgtgtccg gatcgttaaa 2616901 agggtatgta gccgggaata ggtacccttc aagcgggtgc ttaatgtttt tattgaaaac 2616961 atcatttgtc acagtgtccg ggaattcttt cttcagctga ttgataaatg tttcatcgtc 2617021 cagcttcgct atgacttgtt ttttagagta ttttgtttca tcagcaatag cagccgcgat 2617081 ttgggtcagc tgtgctccct cagtcactgt gatttgaaaa gcgtaacctg tagccccgct 2617141 tgtcagcttc tgaataatgg catctaaatc cataccttta ttcagatggt agaatccggc 2617201 ctgaaacccg gaagcacctt tatatttcac atagtactga aacgccttct cgctttttat 2617261 gacatcattt ttctttaata tcgatgcgat ggctgaaaca gacgaaccgc tcggaatgtt 2617321 aatattaact gtcgttttac tgtctttttc aacaggttca agcaatgatt tcccatataa 2617381 aaatgccccg ccaatgatga gaaacagcac aacaatggaa gacagtatga ttcttttttt 2617441 attaaaaaac gatttttttt gctgattgat atacattagg tctcctccca tcagctctta 2617501 tactacatga ttcattgtat ttcggcaatt tattacaaaa agaggcctgc ataaagcaga 2617561 aaaaagccgg agcagtatag ctccggcttt ggtttggcgc gatgttttac tcttcgtctt 2617621 cgtccgctaa gaatgtgttt agtgtttctt cgatcatatc ccattcttcg tcagtttcaa 2617681 tcgggaatag ctcaccgttt tcaccgtctt cgtttggcgt gaagctggaa gcaagaattt 2617741 ctacttcttc gtcatctttt gattcgattg gatagtacaa gacataagat ttgccaaact 2617801 cttcattttc aaatgtaaac agcacttcac aaagctgttc atttccttga tcgtcaacaa 2617861 ttgtaatatt tttttcgccg tgttccattt tcttcacctc tggctttaat ttaagctgtc 2617921 aagatatcct tgtaaaatca taacagccgc cattttatca atgacttttt ttcgtttttg 2617981 cctgctgacg tcagctgcaa tcagcatttt ttcagccgcc attgtggtaa gacgctcgtc 2618041 ccacagcaca acaggaacat tgtacgttgt ttcaagcact ttcgcaaatg tttggctggc 2618101 ttcgcctctc gggccgactg ttccgttcat gttcttagga aagccgagca cgattttatc 2618161 tatagtatag tcctttatca gttcagataa acgggataaa ccataatcgc cttctgcttc 2618221 atttatcttt atggtctcaa tgccttgagc agtccagccc atttcatcgc tcagagctac 2618281 accgagtgtt ttggttccta aatcgagtcc taatattctc attctttatt tacgcctctt 2618341 tatgctgttc taaataagac tttaccaatt cctcgattaa ttcgtctctt tcaagtttgc 2618401 gaattaaatt gcgagcgtca cgatgcctag gaatataagc gggatcacct gacagcaagt 2618461 atccgacaat ctggttgatt ggattgtagc ccttttcctg aagcgcgtca tacactgtaa 2618521 tcagcacctc atttacgtta gtctcagcag aatcatcgga gaaattaaat ttcatcgttt 2618581 tatcaaacga gctcaccgtt ttgcacctct ttcccaaatt cgcaggcaaa gttcagcctg 2618641 gggtcctaat cttaccatca ttctacacta catgggcgaa ttataaaacg gatttcaccc 2618701 aatcttctac agaagccaaa gcttcttcta atttttccgg ctgtttaccg cctgcctgcg 2618761 ccatgtccgg acggcctccg ccgcctccgc cgcaaacttc cgcagcttgt ttaaccagct 2618821 tgccggcgtg aagtcctttc tcaatgaggt cctttgtgac tccggcagag atattaactt 2618881 tatcgttttg taccgcacca agcacgatca ccgcagagcc aagctttgct ttgagttcat 2618941 cgaccatagt gcggagatga ttcatgtctt ttgcatttac ttttgccgca agcacgttta 2619001 cgccgtcaac ttcttttact ttcgacagga ttgctcctgc ttccacgttg cctagttttg 2619061 caagaagaga ttcattttct ctttgtgcat ccttcagttc agcctgcaga gccgcgaccc 2619121 gtttcggcac ttctttgata tttgttttca gctcgtcagc ggtctgcttc aatacagaaa 2619181 tctggctgtt catttcgacg taagcgcctt gtcccgttac agcttcaatc cgtcttgtgc 2619241 ctgctccgat tccggattca gaaacgattt taaacaagcc gatttctgct gtatttctga 2619301 cgtggcagcc gccgcacagc tctaagctgt aatctccaac ttgaacgaca cggacaatat 2619361 cgccatattt ttcgccgaac agtgccatcg cacccatttc ttttgcttca gcgatcggtt 2619421 tcaaatcaat gctgaccggg atgctcgccc agatcttttc gtttacgatt ctttcaattt 2619481 gttcgagctc ttcttttgtc acttggccaa agtgcgagaa gtcaaaacga aggcggtttt 2619541 ccgttacaag agagcccgcc tgattgacat gagttccaag aacatctttt agagcctgat 2619601 gcaataaatg cgttgccgtg tggtttttaa tgacgccgct tctcatatgg tcttcaactt 2619661 cagccgtaac atgcaggcct ttttgaacag taccgctctc cacaacacct tcatgcacat 2619721 gctggccgtt cggcgctttt tgaacatctt taattcttac aactgcctgc tcgcttcgga 2619781 gatagccttt gtcgccgatt tggccgccgc tttctgcata gaacggtgtt tcatcaagaa 2619841 tgatttgaac gctttctcct tcatgagcct cttcgattaa ttggccgtcc tgaagaagca 2619901 caatgatatt ggcatcagct ttggtttgag agtagccgac aaatgtgctt tcaactgtca 2619961 cgtcgcgcag tgcgccgccc tgcacctgca tgctgccgac atcctggcgg gcgtttcttg 2620021 cccgttcacg ctgctggttc atttcctcct caaagccctc atggtcaacc gtcatgttct 2620081 cgtcttctgc gtattcttca gtcaattcaa ccgggaatcc atacgtatca tacagtttaa 2620141 acacatcagc acctgagata acgctgctgc ccttgtcttt ttcttttttg atcatttctg 2620201 acaggatcgc aagcccttca ttaagggtct catggaagcg ttcttcctcg gttttaatga 2620261 cttttgcgat gaaatccgct ttctctttca cttcaggata gaaatcagcc atgatttctg 2620321 cgacaaccgg cactaaatca aacatgaacg gacgatggat gttgatcgtt ttggcataac 2620381 gcacggcacg gcgtaataag cgtcttaata catagccgcg gccttcattt gacggcagcg 2620441 caccgtcact gacagcaaag gcaaccgttc tgatatggtc agcaatcact ttaaacgcag 2620501 tgtctttcac attgtctttg ccatatgttt caccagaaat cgattctgtt gctttaatga 2620561 tcggaacaaa caaatcggtg tcaaagtttg tcggaacatt ctggatgaca gacaccattc 2620621 tttcaagacc catgcctgta tcaatatttt tctttggaag cggtgtgtac gtgccgtcag 2620681 ggttatggtt gaactctgag aacacaaggt tccatacttc caggtaacgg tcgttttccc 2620741 cgcctgggta aagctccgga tcttctggat cattaccgta tgcttcaccg cggtcgtaaa 2620801 agatttccgt attcggtccg ctcggccctt caccgatatc ccagaagttc ccttccagac 2620861 ggataattct ttcttcagga ataccgattt ttttcgccca aaactcatat gcctcttcat 2620921 cttcaggatg aaccgtaaca gagagaagct ctttgtcgaa gccaatccac ttgtcgctcg 2620981 ttaaaaactc ccaagcccat gtaatggctt cttctttgaa ataatcgccg atggaaaagt 2621041 ttccgagcat ttcaaagaaa gtgtgatggc gcgcagtttt acctacattt tctatatcgt 2621101 ttgttctgat cgctttttga gcgtttacga ttcttggatt ttccggcacg acacggccgt 2621161 caaaatattt tttcagcgtc gcaacaccgc tgttgatcca aagcagtgaa ggatcctcat 2621221 gaggcactaa tgacgcgctt ggctctaccg catgtccttt ttctttaaag aaatccaaaa 2621281 acatttgacg cacttccgca gaagttaagt gtttcattgt atttcctcct ctataaaaat 2621341 cgaaattctc ttcagtgaca gcaaaaaagc cctcccccta tgcaaaccaa cgtttacaca 2621401 gggacgagag ctgtctcgcg gtaccaccct gattacgggc attcatgcgc ccgtcacctt 2621461 taaccctgta acgcaggata agcggcagtg attaactgca ctcaggatta gcttcctccg 2621521 atcttctgat aaagctcctt tcagcttatg gagcttctct ctttaacagg gcttcggcgt 2621581 actcagatcc gtcactcgag attcgtatgt attctacgag aaattataga caagcggcac 2621641 gccgatgtca atgctccgtc ctcatccgca aaaaatggat catcattact tttaaaacag 2621701 ccgtcgcagg aacagccaga atcatcccga cgatacccgc aagctcccct ccggcaagga 2621761 gtgcaagcat gataacgacc ggatgcattt taaggcttct gccgacaatg aacggactga 2621821 ggatatttcc ttccataaac tgcagaataa acaccgtaat caccacaaca agaaccgcct 2621881 tgactgagat cgtcatcgca attaacaacg caggaacagc tccgatgaaa gggccaaaat 2621941 acgggatgac attcgttacc ccagagataa ggccaagtat cagcggatac ggaagcccaa 2622001 atacccagaa cgaaatgcct gcaatcacgc caagaatcaa gcagaccaaa agctggccgc 2622061 ggatataatc gccaagcgaa tcatccacat cccgcaaaaa ggcgctgccc cgctttctcc 2622121 acgacttcgg agtcaagtac catactgtct ttttcattaa ctcaatgtcc ttcaccatat 2622181 aaaacacgag aaaagggatt gttgcagcaa ttaagaagta atcaagcaca ttgcggatcc 2622241 cgctgatcgc accctcgatc gttcccgcaa aaaacgcctc cgtctggcgg atcattttat 2622301 ctatacggtg atgcatacca tcaggccagt catccgtatg gttatgcaca tgaagaagaa 2622361 gcccgttata cgtttcggca aacatgggta tattttctga caaatccgtc agctgcacga 2622421 ttaaaacagg caccccttta tacaacgccc agccaatccc gccaaaaaaa agaacataaa 2622481 tgaccaagat gctcaaagtc ctaggcaatc ctttgccatg cagccattct gtgaccggaa 2622541 gcaataaata agatataaaa atagaaatga tcaagggaat aaagatcgtt tttatgacga 2622601 gccaaaaggg tgaccataac atatcaagca taaaaaagac atagactgtt aacagaacca 2622661 gcaaacaaat agccacccac aacaaaagct gcaccggttt ttggagcatc tgctttcacc 2622721 tcacctatat cttttgaggt ttacaaggaa ttattcttta tgtttcttta gtcagtcaga 2622781 agtcatggac attttttcac ttttaatttt cagaaaagtt tgatcattta ctttttggtc 2622841 aaattttctg ataggaggat tgcgatgatc acatttcaaa atgtaaacaa gcattacgga 2622901 gattttcacg tgttaaaaca aattaatctt caaatcgaaa aaggtgaagt cgttgttatc 2622961 atcggcccat ccggttccgg taaaagcaca ttgctcagat gcatcaacag acttgagtcg 2623021 atcaatgagg gagtgcttac agtaaacggc accgccatta acgacagaaa aactgatatc 2623081 aatcaagtgc ggcaaaatat cgggatggtg tttcagcact ttcatttata tccgcataaa 2623141 acagtgctgc agaacatcat gctggctccg gtaaaagtgc ttagacaatc acctgaacaa 2623201 gcaaaggaaa cggcgcggta ctatcttgaa aaagtcggca tcccagacaa ggctgacgcc 2623261 tatccttccc agctttccgg cgggcagcag cagcgtgttg ccatcgcaag aggactggcg 2623321 atgaagccgg aggtcatgct gtttgacgag ccgacatcag cacttgatcc tgaaatgatc 2623381 ggtgaggtgc tagatgtcat gaaaacactc gccaaagaag gcatgacaat ggttgtcgtg 2623441 acacacgaaa tggggtttgc caaagaagtt gccgaccgga ttgtcttcat tgacgaagga 2623501 aaaattttag aagaagcagt gccggctgaa ttttacgcga acccgaagga agaacgggcc 2623561 cgcttattct taagccgtat tttaaatcat taaaacagaa atgggggagc ttgtatgaaa 2623621 aagatttttt ctttagcatt gatttcttta ttcgctgtca tcttgcttgc cgcttgcggc 2623681 agcaagggat caaacggaga agcctcaaag gagagcaaaa aagatacgct agccgccatt 2623741 aaagacaatg acaaaattgt cttcggcgta aaaacggaca ctcgactgtt cggtcttaaa 2623801 aatccaagct caggtgagat tgagggtttt gatattgata ttgctaaaca aatcgctaaa 2623861 gacattttag gtgatgagaa aaaagctcaa tttaaagagg tcacctcaaa aacaaggatt 2623921 cctatgctgc aaaacgggga tatcgacgcc attgtcgcca caatgacgat cactgaagaa 2623981 cgaaaaaagg aagttgactt ttctgatgtc tatttcgagg ccgggcaatc gcttctcgtg 2624041 aaaaaaggca gcaaaatcaa gagtgtcgag aatcttggca aaggctcaaa agttcttgca 2624101 gtaaaaggct ccacctcctc tcaaaacatt cgtgaaaagg cgcctgaagc atctgtttta 2624161 gaatttgaaa actacgcaga agcctttaca gcccttaaat cggggcaagg cgatgccctc 2624221 accacagata atgcaatttt atatggaatg gctgatgaaa ataaaaatta tcaattaaca 2624281 ggaaagcctt ttacagatga gccttacggg atcgccgtga aaaaagggca atctgctctc 2624341 gcgaaagaaa tcaacgcttc acttaaaaag atgaagtcgg atggcagata cgatgaaatt 2624401 tataaaaaat ggatcaaaga agacccagct gaataacaac catcccggga tgagcaggcg 2624461 atgctcatcc caatttgata aggagtgaat aggcagatga atgtgtcaat tcttttcgat 2624521 aacttcagca tgtatatgga cggtttttac cataccttgc tcgcaagtgt tatcgcgctg 2624581 gccggcagtt ttgtcctcgg cgttgctgta gcggttatga gaataacagt ctttaagccg 2624641 ctgcaatggc tcgggaccgc atatgtagaa ttcatccgca acatccctct tcttttaatt 2624701 acctttgttt tctatttcgg acttccaaac gcaggcctga ggcttgacgg ttttcaagcg 2624761 ggaacggttg ctctcaccat ttatacctct gcgtttatcg ctgaagccat cagagcaggc 2624821 atccagtctg tttcaaaagg gcagatggaa gcggcacgct cgtcaggctt tacctacagc 2624881 caagccatgc tccatatcat tttgccgcag gcaatcaaaa tcgtcattcc gcctttaggc 2624941 aatcaatttt taaacttagt caaaaactct tcgattcttg gggttgtggc cggattggat 2625001 cttatgtacc aagccgattt agtttcgtcg agcacactcg ttgtatttga tgtttatatt 2625061 tttgtggcgc ttttttactt agtgctgacg attccgctta gcatcggtgt taactatctg 2625121 gaaaaacggc tggaaaaaag ctattgataa ggagtgagtt acattggatt tcatcggtgc 2625181 ttattcacag gagcatttag cgtttttatg ggatggcttt ctcgtcacct tgtacgttgc 2625241 tttcatctcc atcattctga gctttttctt cggtttaatc gcaggcaccc tgcgttatgc 2625301 gaaagttccc gttctttctc aattgattgc agttctcgtt gaaacgatca gaaacctccc 2625361 cttgctgtta attattttct ttacgttttt tgcccttccg gaaattggga ttaagcttga 2625421 aattacagct gctgcaatta cagcactaac gatttttgaa tccgctatgc tatctgaaat 2625481 tatccgaagc ggactgaaat caattgacaa aggacaaatt gaagcggcgc gctcctccgg 2625541 gctgagctat acacagaccc tgttctttat cgttatgccg caagcgcttc gccgcatggt 2625601 tccgcccatc gtaagccagt ttatttcttt attaaaagat acatcgctcg ctgttgtgat 2625661 cgccctgcct gaactgattc acaacgcgca aattattaac ggccaaagcg ctgacggcag 2625721 ttattttttc ccgatctttt tacttgcggc ccttatgtat ttcgcagtca actacagcct 2625781 ttcactcgca gcaagacgcc tcgaggtccg gcaaacatag aaaaggatac tctttggaga 2625841 gtatcctttt tgcattaaaa cattttcgta attcttcttc tcatccgctt catgcttcga 2625901 ttattcagca tgtcagattg agtcgccatt cggtacacga gagctccggc tcccattgcc 2625961 aaaagagaag tcatcgtccg attcatcctg cgcatctcct ttcatgatta aaaattgatg 2626021 ctgcgttcat cctcagaaaa caaatcatcc aagctgctta acgttccgtc ttcttccacc 2626081 tgatgagttg caatcttccc tttcgccact gtcagttcaa taaaacagcc ccagcaataa 2626141 tattggttca cgccgatttt gccgatatcc ttacttttgc aattcgggca tataagcata 2626201 cctcacacct ctatccgttc agaacgatct cgtctttccg cacctcgaca agcgaatccg 2626261 ctctttggat ctggcgcttg cttcccgcca ggtcagaaaa gaaaccgtcc gagagttcat 2626321 atgctacgat tatgcccctg tccaaacaaa agtatacatc ttccagcatc cccaatatat 2626381 ccccctcttg cgatttcaca agcttcatct tcatctgctc gtatgtgaag catgatttcg 2626441 gaagaggcaa aagctgttct gaactgaccg aagccaatat gcggtcatca aaaatggaag 2626501 agatatcaca cgcccgtaat agcgcatgat gatgatgcaa aaagcgtttt tgtgcaagaa 2626561 taaacccaag acaatctcct ttcagagaaa aacaaatatc ggaaattgtc ccgagataac 2626621 tagaagttcg ttctgagtat actgggaatc cttctacttc atggcatgtt ctcaaagtgt 2626681 gatcaaccac cttttgttga acaggcttag gttttgcttt gcgccttaga ctcatacgat 2626741 gaaatcaatt ccactgcaaa tgaaaaaaaa ctcccgcttg cacgggagca ttttattgct 2626801 gttcttcttt cataaaatcg aatggtgtaa tgccttccat gccaatgttg gcgtcgtgta 2626861 cgctgaacgg gagctctttt tgcaaagctt caagctcggc atccatttcc tcaacctgta 2626921 cggacagcct gtttttcaag gaggtctgtc tgacagttgc atcattattt ttcacgcccc 2626981 actccagcgc ctcctcttcc ccgcataaaa tgagaaattt cttcgctctt gtaatcgcgg 2627041 tataaagaag gtttcttctg agcattctat aatagccttt cacaacaggc aaaaccacaa 2627101 tcggaaattc acttccctgc gatttatgaa tagaacagca atacgcatgg gtaaattgat 2627161 taaaatcttt tttcgtaaat gtcatttcat tgccgtcaaa agaaacgacg gccatgtctt 2627221 ctttttctgt attttccttt gcataaaata tcgacgtgat ttcgccaata tctccgttga 2627281 acacattgtt ttccggctga ttgacaagct gcaaaatttt atctccggtt ctgtagacaa 2627341 catccccgaa cttcaattct ctccgttttt ctttaggagg atttaaaatg tcctgcagca 2627401 tcacattcaa ttcattaatg ccggcttttc ctctgtacat cggagcgagg acctgaatgt 2627461 cctttgctgt atagcctttt ttcaatgcat tggcgacaac cttctcaact acttctttga 2627521 tttgcgaccc gccgcagcga ataaaggaac ggtcctttgt cggggcagtc aaattgttcg 2627581 gcagcaatcc atttttcatc tggtgggcaa gctcgacgat tgatgaccct tctgcctggc 2627641 gatagatgtc tgtcagtctc acagtcggaa tcacctggga tgccagcagg tctctgagca 2627701 cttgtcccgg accgacggaa ggcagctggt cttcgtctcc gacaatgatg atttgtatat 2627761 gatcagggat cgccttgaac aaatgattcg ccagccatat atcaagcata ctggcttcat 2627821 cgataattaa cagcttccct tcgatcggct gatcctctgt atgagtaaag ccttcagcgc 2627881 cgttccagcc aagcagcctg tgtatcgtaa ctgcagggag tcccgttgat tcactcatcc 2627941 gttttgctgc tctccctgtc ggagcggcca aaacaatcgg aaaagcttca tcctttttat 2628001 aagctgacgg gtctagtgac acaccgtgaa gctctccgta gagctcgaca atccctctga 2628061 ttaccgtcgt ttttcctgtt cccgggccgc ctgttaaaag aagcatcggc gaggaaaggg 2628121 ctttttgaat cgcttccttc tggctggggg catactgaac gtccatccgt tcttccagtt 2628181 ctcccaacgc gagcaaaaac tctgattcgg gaaactggtt ctcatattcg gtttggctag 2628241 cgatatgttt cacacgcttt gcaacgtttt gttctgcgta aaacagcgaa ggaaaataac 2628301 agcggccatc ttctatgaca atgtctttat tttctccaag ggcaataatt gcgttagcgg 2628361 catccatttc tgtaatgcgc tgcccttccc ttgctgactg gtttaacagt gattgagtgt 2628421 cgatgatcag ctgttccgtt tctatgtacg tgtgcccctc tgacagacaa gtcgtttcaa 2628481 gcgtgtacaa aatagcagct tttacccgct caggatgatt acccgaaaga cccattctgc 2628541 tgcccagctc atccgctttt ccaaacccga tgccttctac atccttcaca agctgataag 2628601 gattttcctg aatcttttca agcgtctcgg attcataggc ttgatagatt ttcatagaca 2628661 gctgcgggcc aaagccaaac tgattcaagg aaatcatgat ttgctccagt ccctgatgcc 2628721 gctgcaatgc gccagccagc gtgtctgctt tcttttttga gagtctggga acatcataaa 2628781 gcactgaagc atcagccaat attttattaa tggcgctgtc gcccagcttt ttcacaattt 2628841 cttcagctgt ttttttgccg atcccctcga ataaatcact cgataaatat tgaatgatgc 2628901 cttccttagt cgttggaatc tcctttttga aatgctccgc ctgaaattgg agcccgaatt 2628961 ttggatgggt tacgatcttt ccgtaaaacg tgtaggtctc ttcttcttga agcgcaggga 2629021 agtagcccgt cacggatacg gctttatctt caatggcttc ggaggtctct gtgactttca 2629081 ctttcagaac cgtatataaa ttggtgtcat tatgatagat gactgtgttg actgtccctt 2629141 ttaaataggg ctcttcctcc agtttaagct gatccggatg ctgctgcacg agctgtccct 2629201 cctcctgtgc ctgttatgat ggatcaatca gttttttagc atgaagcgca agcatatgat 2629261 ctggctggat atcgattgcc ttgtccagca tttccagcgc tttttctcgg ttttctttat 2629321 aagcataagt gacaccggca ttataaaatg catctgcatg ccccgggtct tgctctgtca 2629381 cagctgcgaa ttggctgagc gcttcgtcca gcatgccctc gttggctaag cacatcccga 2629441 attgaaaacg cgcttccgta tcgttttcat tcagttcgac tgctctttgt aaatatggca 2629501 gtgcaagctt aggctgttcg agcttgacaa gtaccgttcc gagcatgtaa aacaggtcgc 2629561 cgttttccat ccccgcacgt agcgcttttt caaacatgtc tttcgcttct ttgtacattt 2629621 cttttacaac atagacattt cctgctccat aataagcagt ggctgcgcta ctgtctaatt 2629681 caagcgcttt atcataaaac gcaagcgcac gttccagctc gtttacggat gaaagaaggt 2629741 tggcaaaatt gatatacgga atcgcgtctt ctttattttc ttcaatcgct tttgtaaatg 2629801 cctctgccgc tttctcgtaa tcgccttcct gcatcgcctc tataccgagt tgattataat 2629861 ccaccgatca tcttcctttc attaaaaaac cccaactcag tgttgaggtt tttcatcttt 2629921 tatacgtacc acaattttgt tccgtctttg tacacatcat caattgtccc gccgccaagg 2629981 cattcttcgc cgtcatagaa gacaacggct tgtcccggcg ttacagcgcg gacttgttca 2630041 tcaaagatga cttccgcttc accttcgcca gtcatgcgca ctgttacttt atgatcctct 2630101 tggcggtaac ggaatttagc cgtgcaggaa atctcttcgc ccttcatgat atccgaacgt 2630161 acccagctga tatttgttgc tgtgattttg tcggaatata aaagcgggtt atggaaccct 2630221 tgatctacgt agaggatgtt cttttcaaga tctttgccta ccgcaaacca cggctcgccg 2630281 cttccgccga tgccaaggcc gtgacgctgt ccgatcgtat agtacatcaa cccgtcgtgg 2630341 cggcctttta cttcgccgtc catcgtcatc atatcgcccg gctgtgcagg gagatattgg 2630401 ctgagaaacg ttttgaagtt gcgttcgccg ataaagcaga tgcctgtact gtcttttttc 2630461 gtcgctgttg caagttctgc ttctttggca atttcacgca cacggctttt ttgaagttcg 2630521 ccgatcggga acatgacttt gctcagcgta tcttctgtca gctgattcag gaagtacgtt 2630581 tgatccttgt tttcatcaat gccgcgcagc attctgactt ttccgccgct tctgtctact 2630641 cttgcatagt ggccagtcgc taaatagtcg gcgccaagtg acaatgcatg ctccaaaaag 2630701 gccttgaatt taatttcttt gttgcacaat acatccgggt ttggtgttct gcctgcttta 2630761 tattcatcaa ggaagtattg aaataccttc tcataatatt gcttttcaaa gtttacggca 2630821 taatacggaa ttccgatttg gttgcagacg cggatcacat cttcataatc ctctgtcgcc 2630881 gtgcaaaaac cgttttcgtc cgtatcatcc cagtttttca taaagattcc gattacatca 2630941 tagccctgtt cttttaacag cagggccgcc acagatgagt ctactccgcc ggacatgccg 2631001 acgacgactc ttgtatcctc cggccgtttt tccatttcat tcactccaat tactacgccg 2631061 ccttattatg tcagccgttt gacaacgtcg gccacatgtt tggcagcagt tttcacttgc 2631121 tcagccgtat tgccgaggcc gaagctgatt cgaatagagg acgtcagccg gtcactctct 2631181 tcgccgaaca tagcagtcag aacatgtgac ggcaggactg aaccggccgt gcacgctgaa 2631241 ccgctggaga cagcgacacc agccatatca agattaacca gcagcgcttc cactgacaca 2631301 ccggggaaat aaagattcag aacatgcggc agactatgct ctttgtcccc gttgacctcg 2631361 aatgccacac ctgcatctct aagcgtgtcg gcaaagattg ctttaaacga ttgatacttc 2631421 tcgttttttt cgtcacgttc ttcacttgac agcttgatcg cttctttcag cccgacaatg 2631481 cctggaacat tttccgttcc ggcacggcgt tttctttctt gctctcctcc gaataaaagg 2631541 ggtgaaagct tcacatcttt actagcatat aaaaagcctg tcccttttgg cccgttgagc 2631601 ttgtgcccgg aaacagacag aaggtcaata tggctgtttt tcacatcaat tggcagcaac 2631661 ccgaatgcct gaacagcatc ggtatgaaaa taagctttgt gttcctttaa cagctcaccg 2631721 atttcttcga tcggctgcac tgttccgact tcattatttc catacatcac tgtcacaagg 2631781 attgtatcat cacgcagtgc ttctttcacc tgttttgcac tgactcttcc attttggtca 2631841 acgtccagat acgttatgtc aaatccgtct ccctcaagtt tttcacatgt gtgaagcacg 2631901 gcgtgatgct caatttttgt tgtgatgata tgtctgccaa gatcttttct tgcaagtgcg 2631961 gttcccatga tcgccaagtt atcagcttcc gttcccccgc ttgtaaaaat gatctcctgc 2632021 tctgccgctc cgatttctgc tgcgatctgc gctcttgctt catccaccca ttttcgagat 2632081 tctctgccaa atgaatgaat actggaggga ttaccgaaac tgccggagaa gtgcggtatc 2632141 atttgttcca gcacgcgctc atccatcgga gacgttgcgg catgatctaa ataaatccgt 2632201 tccattatgt ttacacctct gatctaaata tagaacatat aagcttcttg ctctccgtct 2632261 gtatagctgg caagatcctc taatgttgta ctgtctaaaa cctcttttac agcatcccgg 2632321 atgcgaatcc agagctcacg cttggcaggc tcctcatctt ccagcacttc aacagggctg 2632381 atcggcccct caagcacacg gataatatct cccgcagtaa tggcatccgg ctcactgcct 2632441 aatacatatc cgccatatgc gcctctgatg cttttcacta aaccggcatt tctgagcggc 2632501 gataccagct gctccaaata atgctcggac aaattattcg tctgtgcgat gctttttaat 2632561 gaagtcgggc cttcaccgtg cttttttgca agctcgatca taatggtgag cccgtatctt 2632621 cccttagttg atattttcaa catgaacacc tctgttattt catgattttc cacatttata 2632681 atggtaattt ctatatgttt cgtccgttta ttatcttata gaccaactgt tattataaca 2632741 taccttcagc gaattttcat tgaggcagaa ggaaaggggc ctttaccctt ttctaatgta 2632801 cggttttccg ttaccctgta attaagtaag gagagatgat agatgaagcc attggcatat 2632861 cggatgcgtc cgacaaaaat agaggatatt atcggccagc agcatctggt ggctgaagat 2632921 aaaattattg gcagaatggt ccaggcaaaa catttgtcat ccatgatttt gtacgggccg 2632981 cccggaattg gaaaaacatc aatcgcaaca gcaatcgccg gttcaacaag tattgctttt 2633041 cgaaagctga atgctgtcat taacaataaa aaagatatgg aaatcgtagc tcaggaagcc 2633101 aagatgtccg gccaagtgat tttgattctg gatgaagtcc acaggctgga taaaggaaaa 2633161 caggattttc tattacccta tttagaaaac ggaatgatca ttttgatcgg agcaacgacg 2633221 gctaacccgt atcatgccat taatccggcg atcagaagcc ggacccagat ttttgagctt 2633281 gaaccgttaa cacctgaact gattaaacag gcactggaac gtgcgctcca tgatgagcat 2633341 cggggccttg gcacctattc tgtatccatt gatgatcagg cgatggagca ttttgcccac 2633401 ggatgcggag gagatgtccg ctccgcttta aatgcgcttg agcttgccgt gttgtcaacg 2633461 aaggagtcag cagacggtga aattcacatt acattagaaa ccgcggaaga atgcttgcag 2633521 aaaaaaagct tttctcacga taaagatggt gacgcgcatt atgatgtact gtccgctttt 2633581 caaaaatcaa tccgcggctc tgatgccaac gctgctcttc actatttggc tagattaatt 2633641 gaagccggtg atctggagag catcgcaaga cgattgcttg ttatcgccta tgaggatatc 2633701 ggtttagcaa gcccgcaagc cggccctaga gtgctgaacg ctattcagac cgctgagcga 2633761 gtcgggtttc ctgaagcgcg aatcccgctg gccaacgcag ttattgagct ttgcctctca 2633821 ccgaaatcaa actctgccat tctggcaatc gatgaggccc tggcagatat cagagccgga 2633881 aaaattgggg atgtcccgaa gcatttaaaa gacgcgcatt ataaaggagc tcaggaatta 2633941 ggaagaggaa tcgactataa atacccgcac aattacgaca acggttgggt cgaacaacaa 2634001 tacctccctg atcctctgaa aaataagcaa tactataagc cgaaacagac tggaaagttc 2634061 gaatctgcct taaagcaggt gtacgataaa ttaatgaaaa gaaaataaaa caaaaaaaca 2634121 gccttgatca tcaaggctgt ttttatgcat tatttatcct tcacacgttt gatttcaatg 2634181 tctttcaaaa gatccatgac aacatgtccg cccataatca aacctgcaac tgacggcaca 2634241 aaagcattag aggaaggcgg catttttgct ttacgtattt tcgcttcgtc attccccact 2634301 tcttttctga catcttcccg aataacaatc gggctttcat cagagaaaat cacttgaacg 2634361 ccttttttga taccctcctt gcgtaatttc gtacgaacga ccttcgcaat tggatcagtg 2634421 tgcgtttttg agatatcagc gatttggaag cgtgtcggat ccgttttatt tgcagcaccc 2634481 atgctggaga tgagcggaat atcccgtttt agacattctt tcattaaatg aattttataa 2634541 caaatggtgt ctgacgcatc aatgacatag tcaagaccat agtcaaaaaa ctgctcatac 2634601 gtttcctccg tatagaacat ttttaacgcg atcacttcac actccgggtt aatgtctgcg 2634661 atccgcgcct tcattaaatc aactttcggc tgtccgacag ttgaaagcag cgcgtgaagc 2634721 tgacgattta catttgtaat gtcgacatca tctttgtcga caagcagaat gcggccgacg 2634781 cctgaccgcg cgagagcttc cgccgcgaac gacccgactc ccccgactcc aagcacagca 2634841 actgtgctgt ttttcagcgt ttcaaggcct tcttttccga tagctaattc attgcgtgaa 2634901 aactggtgta acaagaacct cactccacat tcgtattctg gtttcatcta taaaatggct 2634961 gatccatgag cagccgtttt ttctgcgcac aaaaaataaa gtcccaatag tgccgttgca 2635021 gctttccttt gttttgaacc cgctctcagc aggtgggtgc cctcttttaa atcttgtaag 2635081 tcctctttac cgaatgaaaa gaggcatgta cgccatttaa aaatgcgggc tcccaaatca 2635141 aaaaaatgtt cggtcaaaac taggtgtaca actaacacat caggacttta tttaacttgt 2635201 caaaatcata tcacagacga ttttgatttt caagaatcga actgcaaatt cagttcttaa 2635261 cttttttctt gatagaaaga tgaagctcgt caagctgggc gtcgcttact tcgcctggcg 2635321 cttctgtcat caggcagctt gcacttgccg ttttcgggaa tgcaatcgta tctctcaggt 2635381 tcgtacgtcc agcgagaagc ataacgagac ggtctaagcc gagtgcgatt ccgccgtgcg 2635441 gaggagcgcc gtattcaaat gcttccagca ggaatccgaa ctgttcagcc gcttcttctg 2635501 gtgagaagcc gagaagcgca aacatttttt cctgaatatc cttttcgaaa atacggattg 2635561 aaccgccgcc aagctcatag ccgtttaaga cgaggtcata agcttgcgct ttcatgtctt 2635621 caggcgctgt ttcaatcagc tcaaggtctt ctcggacagg cattgtgaac ggatggtgcg 2635681 ctgcgtaaaa acggccttct tccggatcat gctctaatag cggccagtcg atgacccata 2635741 agaaattgaa caatttttcg tcaatcagtc cgcgttcttt cccaagcttt aagcgcaggg 2635801 cgccgagtga tgcggccaca acttcgaatt gatccgctcc gaacagcagc aaatcacctt 2635861 cagcagcatc aagtgcttca atcagcttag actgcttttc ttcatcaaag aatttagcga 2635921 tcgggccttt cactccgtct gcctcaacct tcacccaggc aagccctttt gccccgtagt 2635981 ttgcagcaaa agcgccaaga gcgtcgatgt cttttctgga gtaatcgccg gcaccgcctt 2636041 ttacattgat ggctttgacc acgccgccgt ttgctacagc tgatgagaac actttaaatt 2636101 ccgtatcctt tacaatgtca gacacatccg tcaaaagcat gtcaaaacgc gtatccggtt 2636161 tatcagaccc gtacttgttc attgcttcgt catacgtcat tcgaggaaga ggaagctgaa 2636221 gttcctcacc ttttgtttca cgcataacct ttgccatcat ctcctcagcc aatgacataa 2636281 tgtcttcctg gctcataaag gacatttcaa tatcaatttg cgtaaactca ggctgacggt 2636341 ccgcacgcaa gtcttcatcg cggaaacagc gggcaatttg ataatatcgt tcaatgcctg 2636401 ataccatcag aagctgttta aatagctgcg gagactgcgg cagcgcgtag aactcacctt 2636461 cgtgcacacg gctcggcacc aagtagtcac gtgcgccttc aggcgtgctt cctgttaaaa 2636521 tcggcgtttc aatatcaaga aacccatttt catctaaaaa gctgcgaaca gctttcgtca 2636581 cgttatggcg cagctgcatc gtctggaaca tagccggtct gcgcaaatct aagtaacggt 2636641 gttttaaacg aacgtcctct gacacttctt cagcttgatc agaaatcgca aatggaggtg 2636701 tctttgcagc atttaatacg ttcactccat cagcatgtat ttcgatcgcg cctgttttca 2636761 aattcggatt aactgttccc tcttcacgcg ccaccacttt tccttgaata tcaagcacgt 2636821 attcatttct gatgccttcc gcaatagcaa gcgcttcttt tgacacatca gggttaaaaa 2636881 cgacttgaac aatgcccgta cggtcacgca agtcaataaa aatcaatccg ccgaggtctc 2636941 gtcttttttg gacccagcct ttcagcgtta cagattcgcc aattgctttt tcagttatat 2637001 caccgcaata atatgttctt ccaaacaatg cgtttcactc cttatccctt ttggtttgcc 2637061 ttcatcacat gtataaattc atcaagtgcc acttcaatct gttcgcccgt ctgtgcatcc 2637121 tttacattga ttttgttttg ggcaagctca tcttcaccca aaatcgcaat aaatctggcc 2637181 tttaagcgat cagctgtttt aaactggcct ttcattttct tattttcata atcgatttca 2637241 ctggaaatgc ctgcttctct cagtttgtac accaatgaaa cagaataatc ctttgctttt 2637301 tcgccgagtg tgacgatata gcagtcgatt cccttatcaa caggcagctc tcttttttca 2637361 gcatcaattg cggcaagcaa gcgttcgatg ctcatcgcaa atccgatgcc cggtgcttca 2637421 ggtccgccga tctgttcgac aagcccgtcg tagcgtccgc cgccggcaag tgtcgtaatc 2637481 gcgccaaagc cctccgcatt gctcataatt tcaaatgcgg tgtggttgta ataatccagc 2637541 cctctcacaa ggttcggatc gatttcatac gaaatgccaa gatcatttaa gtattgtttc 2637601 actttttcaa aataagcggc tgattcttca tttaaatatg tcaaaatcga aggtgccgat 2637661 ttcatcagct catgatcacg gtcttttttg cagtccaaaa ttctaagcgg gttcgtgtgc 2637721 agccgggact ggcagtctga acaaaattct tcgatgcgag gctcgaagtg tttcacgagc 2637781 gcttctctgt agcttttgcg gctatcttga tcgccgagac tgtttatgac aagcttaacg 2637841 ttttctaaac ctgctttttc ataaatactc atcgcaagcg ccattacttc agcgtcgatt 2637901 gcagggtctt tcgaaccaat cgcttcaatt ccaaactgat aaaactggcg gtaacggccc 2637961 gtctgaggac gttcataacg gaacatcggc ccgacataat aaagctttgt cggctgtaca 2638021 ggatttgcga acagcttgtt ttcattaaaa gcgcgaaccg cagcagctgt tccctccgga 2638081 cgaagcgtca ggcttctgcc tttgcggtcc tcgaaggtat acatttcttt ttgtacgata 2638141 tccgttgatt ctccgacgcc tctggcaaac agttctgtat gctcaaaaat cggtgtgcgg 2638201 atttctttat attgataagt gcggcaagtg tctctcataa tttgttcaac aaactgccag 2638261 cgatctgatt ctccaggcag aatatcctgt gttcctctcg gaatgttata tcccataggt 2638321 agacctcctt atgtattcct tataaaatat ccaatgatcg ttaatgatga aaatgaaaaa 2638381 aactcccgcc cctactatac atgatagtag ggacgagagt tatacccgtg gtgccaccct 2638441 agttggaata cgttcatatt cccgctcgat cctttaacgc aggttcacgt tcactgccta 2638501 atggcgttat tcacgcgttc agcaggaaac ctccggagtg ttgtttcgag aaagacgcaa 2638561 tgggatccgc tttcagcctg gggcgggttc ctctctaatc atgcaatctg acctactctt 2638621 ctccattatt ggttcaaatc tttcatcatt tgctatgtac tcaatttcta ttataataat 2638681 gggattgggg ttctctgtca agctttattc cggttgtttt tcctcagcgc tgcttctttg 2638741 gacataagac caaattcaga tgctgtttcc gtaagataac cagtcgtatc gggatctgcg 2638801 tgatcgctgt aatgcagatt cgcttcaccg tcgtgaaatg cacgtcccat ttttggatga 2638861 tatttcatga tttgcacacc tttttgattg tatttacgct tagtataaac aaatcatttt 2638921 atttttattt aaaaatcaga aaggacttta cgatattaaa caagaatgct tttttaatga 2638981 tcatcagaaa ggaggacaca atgaacaaga aatactttgt ccttattgta tgtattattt 2639041 tcacctcagc gctattcccg accttttcat ccgttacagc tgctcaagga gaagcggtca 2639101 tcgcaacaga tgaaatgaac gtcagaagcg gcccagggct tagctacggc attacagcgg 2639161 aagtaaaaaa gggagaacgc tatccaattt taaaggaaga tggagactgg gtgcagatac 2639221 agcttggttc tggagaaaag ggctgggtag tctcctggct tattacaaag gaagaccagg 2639281 ccagcacaag ctcctcagga agcagtgaca ctgtgacatc aacagacccc gatctgcgga 2639341 tgagaagcgg cccgggcact tcctacgaag tcatcggcaa attcccgcaa ggcagccaag 2639401 catctgtcat tgataaagat tcgggctgga tcaagatatc ctatcacagt gccaccggat 2639461 gggtatcatc tgaatatgtc acatcaggag gcagcagttc agcgtctgat gagagtgacc 2639521 aaaccgagga ttccggtgcg tcaacgacgg gcacagtcgg tgtttcttcg ctaaatgtaa 2639581 gagcctccgc ctcacatgac gcggcaatta taacaaaact tgatcgcgga acgaaactga 2639641 cggttctcaa cgagaaaaat ggctgggctc acattgaggt gaacgggcta aaaggctggg 2639701 ttgcaagcca ttaccttttg actagttctg ttccagctga tgattcagca aatgccggca 2639761 gttcatcctc cgctaaaaaa gcctatatca tgtacggagg aacgaatcta agaagtgatg 2639821 cgtcaacatc agcttcgatc gttgagcgcg ctgccaaagg agattcatac accattaccg 2639881 gttcaaaggg aagctggtat gaaataaagc ttgataacgg gcagactgct tatgtagcca 2639941 attgggtggt ccaaacgtct aaaagcgcag aagaagcagg tgaaccgcca gtctctgatt 2640001 ccccgtctgg aaacggctct ctaaacaata aaacgattat tgttgacccg ggacatggag 2640061 gaaaagacag cggaacgatc gggtattcgg ggaaattcga gaaaaacctg acgatcaaaa 2640121 cggcaaaact gctcgccagc aaacttagat cggctggagc ggatgtatat gtgacacgcc 2640181 aggatgatac ctttgtcagc ctgcagtcac gggtctctac ctctcactac cgtaacgctg 2640241 acgcctttat cagcattcat tatgacagct atgcggatac ctctacaaga ggcagtacag 2640301 catattacta cagtcctgcc aaagatcagg aactcgcatc agatgtccac tcagaagtgg 2640361 tgaagcgttc ttccattcca gaccgcggcg tattattcgg agattattat gtgctccggg 2640421 aaaacagaca gcccgctatg ctgtacgagc tgggatatgt aagccatccg caggaagaag 2640481 ccattgtaca tagcaattca taccaagaaa aagtaacaga tgggatcgaa agcggattag 2640541 agaaatactt ccaataaaaa aagctgcctt ttggcagctt tttttatttt gaatccataa 2640601 tgagcgtgac cggtccggag tttgtaagct gaacatccat cattgctcca aacgttccgg 2640661 tctccacttt gattcctttt tcacgaagca ggtcattcca tttttcataa agacctaaag 2640721 ctttatcagg tttggccgcg ttcatgtagt tcggccggcg cccttttttc gtatctccat 2640781 aaagcgtaaa ctgtgagacg gataaaatct ctcctcctat atctacaaga gacagattca 2640841 ttttcccttc actgtcatcg aaaatacgga gattgacaac tttatcggct aaataagctg 2640901 catcatcttc tgtatcatcg tgagtgatgc cgaccagcac cataaggcct tgtccaattt 2640961 ggccgacgac ctcttcgtcc actgtaacgc ttgcttctgt tactcgctga acaactaatc 2641021 tcttttctaa cccctttagt tcatgacgcg gcgcacagaa tagatatctc taatctgttt 2641081 aatacgctcg acgactttat gcaagtgatt gatattctgg ataaaaatcg ccatatggat 2641141 ggttgccact ttattgcgat ccgatttgcc agagacagat gaaatattgg ttttcgtttc 2641201 attcactgcc tggagtacct cgttcagcaa tccgcggcgg tcatacccaa gaatctctat 2641261 ctcaacattg tattccttgc gcttttgaac ttgtgactca tgttcccact ctaccgggat 2641321 cagccgctct tgggcttcat tcgttttgac attcggacag tcttcgcgat ggaccgaaac 2641381 ccctctgcct tttgtgataa agccgacaat atcatcacct ggcacaggat tgcagcattt 2641441 tgataaacgg acaaggaggt tgtcaatgcc cttgacacga acgccagctt cccgttttct 2641501 tccttgcggg tatggcttag gttccccagt gacttcctga acgatctttt cctgttcttc 2641561 ctggtcgcgc tgctttctct ctttttctgt taggcggttc gccacctgca gagctgtgat 2641621 gccgttgtaa ccgaccgccg cgtacatatc ctcttcattt gagaaattaa atttgtcagc 2641681 aaccttttga atattctccg gcgttaaaac atccttcaat tcaaaatcca agtttttaat 2641741 ttctttttcg accagctcac ggcctttttc gacattttct tcacgccgct gtttcttaaa 2641801 gaattgacgg attttatgct tcgcttggga tgtttgggca agcttcaccc aatcctggct 2641861 cggaccgtag gaatgcttag aggtgagaat ttcaacgata tcacctgtcc gaagcttatg 2641921 gtcaagcgta accatttttc cgtttacttt ggcaccgatt gttttattgc cgatttcaga 2641981 gtgaatccgg taagaaaagt caatcggaac agaaccggac ggaagctcga ttacatctcc 2642041 ttttggcgta aagacataca ccatgtcaga gaacaaatca attttgagcg attccataaa 2642101 ttcttctgca tctgtcgatt cattttgaaa ttctaaaatt tcacggaacc aagaaagctt 2642161 tttctcaaag gttgcacctt cattggctgc tttcccttct ttataagccc agtgagccgc 2642221 aaccccgtat tccgctattt catgcatttc aaaggtgcgg atctgcactt caagcggatc 2642281 gcctttaggc ccaataaccg ttgtatgaag cgattgatac atattcggct tcggcattgc 2642341 gatataatct ttgaatctgc ctggcatcgg tttccagcat gtgtgaatga tgccaagcac 2642401 cgcgtagcag tcctttatgc tattcacaag aatacggaca gccaacaaat cgtaaatttc 2642461 attgaattgc ttattttgca gcaccatttt tcgataaatg ctgtaaatat gtttcgggcg 2642521 tcccgagaag tcagccttga tatttacttc ttcgacacgt ttcttcactt cattgacaac 2642581 ctcatcgaca taaagctctc gttctgcacg tttcttcttc atgaggttga caattctgta 2642641 atattgctga gggttcaaat aacggagcgc cgtatcttcc aattcccact taatttttga 2642701 aatcccgaga cgatgcgcca aaggagcaaa aatttccagc gtttcattgg agattctccg 2642761 ctgtttttcc tgaggcagat gtttcagtgt ccgcatattg tgaagacgat ccgccagctt 2642821 gatcaatatg accctgatat cttgagccat agcgacaaac attttgcgat gattttccgc 2642881 ctgctgttcc tcttgagatt tatatttaat tttgccgagt ttcgttacgc cgtctacaag 2642941 cattgccact tcttcggaaa atgcttcttt caggtcatcg agcgtcacat ctgtatcttc 2643001 cacgacatcg tgcaaaaatc cgcccgcgat tgtggaaggg tccatttcaa gatcaacgag 2643061 tatccccgca acctgaatcg gatgaataat atatggctcg cccgatttgc ggtattgctc 2643121 gcgatgagca tcttcagcgt acagatatgc tttttcgaca aatgcgatat gctcatcaga 2643181 tagatagctg cgtgctttat ctataacttg ctcggcagtc aatacttgtt cgttcgccat 2643241 ggaatcacct tttttaaaat gtaaactgta ttgtagttta ttatcaagaa aaaaacgaaa 2643301 gatgtaaaga gcagaagttc aaatagccaa atattatata aaataaatgc aaaacaatag 2643361 gaaaaaagca ccctgacatg gagtgctttt tcgttatgcg gttatcctta gtatttcatc 2643421 aatgttaaga tgtcgtaatc ttcgagctta tttctgccgt caaggtaaga aagctcgatt 2643481 aagaaagcga taccagcaac aacgccgcca agttcttcaa caagtttgat tgtcgcttca 2643541 attgtgccgc ctgtcgcaag caggtcatct gtaataagca cacgctgacc aggcttaatc 2643601 gcatctttgt ggatcgttaa tacgtctttt ccgtattcca agccataatc cactttgatt 2643661 acttcacgag gcaacttgcc ttctttgcgg accggcgcaa aacctacgcc aagcgcgtaa 2643721 gcaacgggac agccgataat aaagccgcgc gcttcagggc caacgaccaa atcaatttgc 2643781 ttttctttcg catattcaac aatttgatct gtggcatagc ggtatacatc gcctttatcc 2643841 atcagtgtcg taatatcttt aaattgcacg ccctctttcg ggtaatccgg tacaattgtt 2643901 acgtattgtt ttaaatccat ctgttttatg tcctcctcgt actttcataa gcctctgaat 2643961 cttgtttcat cagcttattc agccattcct tcagctcttc agcagaagaa taattcagct 2644021 tttgatccag ttccatcagc tgctgtttcg cctgatatgt ttgtgagtct gttaagtcgc 2644081 gtttctttgc tccgctcaca acagacagca caccattctc tattttaaca aaaccgagat 2644141 caaaaaacac ctttgtcatg aaattgattg tttcaacgga ccagccttta tgttttgcaa 2644201 gctctgaacc gtgttttttc acgtcaaaag cgcctctttt cagcaagaac gcataatacc 2644261 atttaaagtg gtctcttgcg ggaaaagttg ataaaaagtg gtcctcatga ttgagaaaaa 2644321 taaaatatat ccgctcgggc gcctttcctt ccagcaaacg tgcgagcatg tccagcgaag 2644381 gcggcggatc cagtaataca atatatgcac catcgaggtc aaacgccttt gcttgatctt 2644441 tagaactgat gacgtgcact tctcggcgaa ggtcttcagt ttgaagtaat gttgttgagt 2644501 cttctttgaa agagacaatg gcccgtttag cagatggaag ggcggaaact gtgtcttccc 2644561 acgtccgttt tccccttaaa tcaaacagct gccattcaga aacagcggca tcctttatca 2644621 taagctgcgg cttttttcga ttgttccatt cgttgattga catctcaccg acaatggaaa 2644681 ttcttgaacc cggtacgatg ccttcttgaa gctcgccttt attaaaaccg acgcaatcaa 2644741 gctgggacga ctcgtttctg atcgtcattt tgacatgagt tttatttgcc cctatcttgc 2644801 ggacatcttc cagtactgca ttttctacga gaacgtgcgg tttcgggttc agcatgccaa 2644861 aaggagacag catgttcatt tctgcgatgc tttcaactgt aatgtcttcg acgccgcaga 2644921 caaggtcgac ttcctgtacg ggaataaaat cctcttccgt aagcgtattg tccgctattt 2644981 cattcagcct gcttcgcaaa tccggcacat cttcggcttt cagcgtcatc cccgcagcca 2645041 ttggatggcc gccgaaatga ggaagaatat ctctgcattc agaaaggctc tcaaataaat 2645101 taaatcctct gatgcttcgg gccgaacctt tagcgattcc cttttcttca tcaataccaa 2645161 gaacaatggc cggtcggtag aaacggtcca caagctttga agccacaatc ccgacgactc 2645221 ccgggttcca tccggctttg gccacgacaa ttgcagtttg atcgagccct tgctgttcaa 2645281 ccatttcaat cgcttcatcc gtcattttgc tgaccatttt ttggcgctct ttgttcagct 2645341 ggtcaatttc tgcggcaagc tcttccgctt caaacgaatc ctctgacata agcaaatgaa 2645401 cagcgggatc cgcctgttcg attcttccga cggcattcag ccttggtgcg agctgaaatc 2645461 cgactgtttc ttcgttcgct tctccgatgt ctccgcctga cagcttaatc agctctttta 2645521 agccgagccg atttgtccgt cgaagccttt caagtcctag tgttgctatt aatctgtttt 2645581 cgtcatgcag cgggactaga tcggcaatgg tgccgatagc cgccaggtca agcagttcat 2645641 caggaagttc acccaataaa gcgtgggcaa gcttaaacgc gactccaacc ccggcaagct 2645701 ctttaaacgg gtaagtgcag ccaggctgct tcgggtggac gatcgcacgg acatccggaa 2645761 gctccggtcc cggttcatga tgatcggtaa tgatgacatc cagtccgagt tcctttgcca 2645821 ccttcgcttc atgcacagcg gcaattcctg tatcaaccgt aatgatcaaa gagaagcccc 2645881 gttctttaat cgaacgaaac gcctgttcat taggtccata tccttcttta aaacggtcag 2645941 gtatataaaa atcaacttga gccgacagtt tttgcagcgt gtgaagcatc actgacgtac 2646001 ttgtaacccc atcggcgtca taatcgccat atatcataat cttttcttgt tgtgaaatcg 2646061 cctgttttat tcgatctgcc gcttctttca tgcctttcat ttcaaaagga tcataaaaat 2646121 cggcatcctt tgtatgtaaa aacagcctag cgctttctgc cgtatcaaag cctcttttta 2646181 caagcaggga cgcaacaaga ggtgttatat gcaattgttc tgtgagtgat ttgaccttat 2646241 cctgatctgg tcgctggatt tcccatcgca tttttgacgc taacataaat tcacccctca 2646301 accaccctat tatactagag caggctgagg ggtttcaaat aatattcgaa aactagtctt 2646361 ttttctcaat catggctgat gcatcctgtg tgtcagtctg atcagcaaga tgagtatcct 2646421 cttgtttatg tattgctgtt ctattttctt tccgcaaggt ttttatttcc cgcttcaatt 2646481 tcattacctg aaaaatgccg acagaaaata cgatcagtgc tcccattaaa actgagccca 2646541 aaataacaag aatgagcggc cattctgatc ttccaaacag gtaatcaact tctacggatc 2646601 gaacattaat gactgcgaaa atagcgacaa ttaaggtgaa aataagtgcg aaaataatgg 2646661 tccattgttt attcattctc ttttccccca aacttcttat tgaggtaact ttcccaatca 2646721 agactggttt taaacatggc ttaacactag gttaagctcc ctttgctgtt aatttttccc 2646781 ggatcagcct cttcagtccg gttccctcac cggaaatcac aagtgtatcg ccttcgtcaa 2646841 tgactgtttc agagctcgga ttcagttgtt tatcctgatt ctttttaaca attgcaatga 2646901 ccgtcacatg atattcctga cccacattca aatcaccaat cgtctgatga atggcaggcg 2646961 ctcccgcctc tgctttacac cactctataa tcaaatcatc aagggctgac tcgacctgtt 2647021 ctaatgcttt cggtttatat gccattccgc caagaattgc agacatttgc cttgcttcag 2647081 cgtcatcaaa ctgcacggag gcaacacatt cctcatggtc gttttcgtca aaatagtaaa 2647141 gctctctccg tccgtcatga tgaatgataa ttgaaatttt atcacggttt ctagtaatca 2647201 tttcaacttt ttgtcctatg cccggcagct ctgattcgcg aaccctcata tataaaccct 2647261 cctacatatc tgaaaaccag ccataaacac ttttaacacc atatatatgt ttaaatgtaa 2647321 gcgtatgtca ttatagcaaa tgtctatttt aagttcaatg aaacttcaaa aaacaggctg 2647381 ccctgcagag gacagcctga tattttttat tgcgccgaat cttttttcag ttctcttcct 2647441 ttccatgcaa gccaaatttg tgcggcaatg tatagagaag aataaacgcc tgttaacagc 2647501 ccgaccaata aagcaattga gaagttagta atagaagatg ctccaaagat cagcaatgtc 2647561 acaacaacaa tcacaacggt taatacagtg ttaattgaac gtgtaaaggt ttgctgcagg 2647621 ctcaggttta caatatggtt cagatcggca aaggttttcg gcttacgctt tttcatatgc 2647681 tcgcggaccc tgtcaaatgt aacgattgta tcgttaatgg aatacccgat tatcgtcaag 2647741 atggccgcga tgaatgtaac atctacctca agccttgtaa tactgaagaa cgtgacgata 2647801 aagaatgcgt catatagcaa tgaggcgatg gcagcaatcg ccattttgta ttcgaatcgg 2647861 attgaaacgt aaataatgat gccaatagaa gctatagcaa ctgcgtacag cgcatttctc 2647921 gccagctcct taccgactgt cggtgaaact gtgctgacat ttggatcaga tccgtatttg 2647981 tctttaaaat acgtttttac ttttgcaatg gtttctttat ctggcacccc gacaaaacgg 2648041 gcaacaccga tattgctctt ttcgcctgac agaactacag tatcagggtc catacccaga 2648101 gattcaaaat ccttctcaac ttgctctgtc gtcagcttat ggtcgctttg cacttcaatc 2648161 cgtgcaccgc ttgcaaagtc aatgccaaga ttcagcctga acacaagcag gataataatc 2648221 ccggcaaccg tgaccgcact ggagaaaata aagaagtatt tgcgtttgct cgtgaaatcc 2648281 catttttgga atggcgtatg cggctctgta ttttcatccg tatcctgaat atccatgata 2648341 tgtttcttat tgacaccaaa ccagcctttt ttccgatcaa gccatctgct ttccacaagg 2648401 agagcgagga gaaatctcga taagaaaacg gcagtgataa agcttgtcaa aatcgatagg 2648461 atcagcattg tcgcaaaccc tttaacagag cttgtcccaa agataaagag cacaaccgct 2648521 gcaataatgg ttgtaatatt cgcgtcaaaa atcgtcgcaa atgaccgtct gtttcctgaa 2648581 cggaaggcag agcggactga ctttcctagc ttgagctctt ctttaatccg ctcataggta 2648641 ataatgttgg cgtcaacagc catcccgaca cctaaaatga gagcggcaat tcccggaagc 2648701 gtgagtacgg cattcatcca gtcaaagatc tggagtgtaa tgtagatata aacagacagc 2648761 gtaatcaccg cgattaatcc cggcagacgg taatagaaaa gcataaataa gaaaataatt 2648821 gcgataccga caataccggc aaacaccgta tcatggagag cctgctggcc gaattgcgcg 2648881 cctactgatg tcgaatactt ttcagtcagt ttcacaggaa gtgcgcctgc gtttaaaatg 2648941 ctggctaaat ctttcgcttc ttgagctgtg aaatgacctt caatttttac atcagttgta 2649001 tttagttcct gacttacatt tggagcggat acaaatttag gatgctcttt ttgaacttct 2649061 ttcttaaagg aatcaccttt atcataatcc aaccaaatga caagctggtt gtttggcgcc 2649121 attttcatga ccttcttggt cacttcacca aatttatcag cgtctttcag cttaatcgtg 2649181 acaattggct catttgttgt gctatcataa gtttgtttag cgccgttttc gactagatca 2649241 gcaccgttta acagttcctt atcatttgca tctctgaaag aaagctgcgc ttcagtcgcc 2649301 aaaatttcac gcgctctgtt ttggtttgtc acgccagcga gctgaacgcg aatccggtta 2649361 ttcccttcaa tttggatgtt cggttcgctg acaccgagaa cattggcccg gcggttcagt 2649421 gcctctactg tgctgaccag aacgtctttt gtgattttgt cacctttttt tacaggctgt 2649481 acatcataca gcacctcaaa tccgccttgc aaatccaatc ctaacgtaat attgttagcg 2649541 gcaggcttcg taaagtagcc caagcccgtg ccgatcaata gaacgaaaag gaaaaacgca 2649601 atcaagcgtc cttttttcat tatgtatatc ctcccttaaa cctgtgcgaa tcaacctgct 2649661 atctcagcag ttcttccaat gcttcctggc cctcttcact gcccagccaa ttagacgttt 2649721 taaatgactc aacggttgca tagttcataa attcgccaat tttcactgat aaaatatcac 2649781 tcgccagttc ataaatgctc agttccgttt tctttttcca cttcttatct gttaagtatg 2649841 accacaaact ttcgagttca acatcatcat acccgagaat cttaaactct tccagtttgc 2649901 tgtaaagaaa cggcctgacg tggtctttat atagatcggc tggatgcttc tccacgaatt 2649961 ccacgctcct tttttattgt ttttcaagaa gacttgtcat gcttggacga catatacgca 2650021 tatctttatt gtatatgatt ccaggtagtt tgagaaggca gggggtaaaa atggcgaaac 2650081 agacgttttt aaagggcact cttatcctta tcgcagcagg aatggttaca agaatgctcg 2650141 ggtttgtcaa ccgggtggtt atcgcccgtt ttatcggtga agaaggagtc gggctttaca 2650201 tgatggcagc gcctactttc ttcttggcca ctacattaac tcaattcggt ctgccggtcg 2650261 cgatcagcaa gctagtcgct gaagccagtg cgcgcggaga tcatcaaaaa acgaaaaata 2650321 ttttagtcat gtctctgacc attacgggag tgctcagcct catctttaca ccgctgtttc 2650381 tgtttttcgc ccctgttatg gctgaaacga tgctgacaga taagcgaaca ctgtatccgc 2650441 tcttggccat tacgcctgtt gtgccgatta ttgctatatc gagtgtgctg aggggatact 2650501 ttcaaggaaa acagaatatg aacccgcttg ctatgtcaca agtccttgaa caggttgtcc 2650561 gcatttcact cgtggctgtc tgcacaacga tttttctccc ttacggaatt gaatatgctg 2650621 cagcgggggc aatgctatcc tcagtggcag gggagctggc atcacttctt tatttattcg 2650681 tttgctttaa gtataaaaag acaattaaaa tcagaaagca ttttttacag tcaattaaaa 2650741 acggaaaaca aacctttacc caattaatga gcgtgtccct tccaacaacc gggagccgct 2650801 ttatcggaaa cctctcttgg tttttcgagc caatcgtcgt cgctcaaagc cttgccatcg 2650861 ccggtgtggc aacagttgcc gcaacaaagc aatacgggga actaaccggc tttgccatga 2650921 cgctgctgac tctgcccagc tttattacat attctttgtc gaccgcgctt gttcctgcga 2650981 tcagtgaagg aatggagcag aaaaaattgc aggtggtgga ataccgctta gaacaggcga 2651041 tgcgtctctg tctgctcagc ggaggcattt cagttgttat tttatttgta tttgcggatg 2651101 agctgatgag agtgatgtac ggttcctcag gcgcagctgt atttataaaa gtgatggccc 2651161 cgttttttct gctttattat ttccaaggcc cgcttcaagc tgtgctgcag gcgcttaatt 2651221 tggcaggagc tgcgatgatg aacagcttaa tcggagcgct tgtcaaaaca ggccttattt 2651281 ttgtccttgc cacaaggcct tctcttggca ttatgggcgc ggcattagcc attgtgacag 2651341 gcatggtgct cgtcacgcta ttgcacgcag caaccgtaag caaagtgctg ccgatcagca 2651401 tcaaaatcaa ggagtacgcg ctcagcttcg ctgttattgt aatttgcgga ttcatcagct 2651461 ccgccatcaa acaatatata agctttggag catctgaggc tgtcaatcta gccggatgga 2651521 ttgcggcgag cgccgccatt tatatgatcc tcctgctcgt tttccgttta attaaaaaag 2651581 atgagcttcg ccgcattccc attatcggac ggttgatcat ccgataatgg tcacgtgcgg 2651641 tgcccatctt tttcatcaat atatatttct ccgtctgtaa acgagcaaaa tgaaatatct 2651701 gaagggtttg tgtatccgtg tttttgcaaa ctttcaagca gccattttct atctttactg 2651761 attctggaca ggttttctgt ttgaatgaag ccgtctataa tgagcggcat ttcgagctgc 2651821 cgatgctctc cgctgttttc tttcttaaca atagtcagtt tgcccgacgg ctctaaaata 2651881 gcaaatgata cgtcagctac tctgtcgatg ctattttctc tgagctgaac cattaaatca 2651941 tcaaaattat aacgctgtga tttcatggct tcttcgtcaa tttttccata tttgataatt 2652001 atggtcggct taccgtcaag aagctggcgg acttttcggt tttttaaaga aaagtatgcc 2652061 aaagtcactt gaatgatcat taatacaagc attggcaaaa tggtatgaaa tagatgatcg 2652121 tctacgtttt ctatggctaa aacggcaatt tcagccatca tgataaagac aacgagatct 2652181 aaaatactaa gctctccgat ctcccgtttg cccatgaaac gaaaaatgac caatatcaca 2652241 aaatacaata cgactgtgcg aaacgcaata gtgagaagct cttccattat gcacctccaa 2652301 ctcattatag gttgcaacaa aatgatcaat ttatgtaaga aaaaccgatt gcatttcaca 2652361 aagcttttac gtctaattca tgggataagg gaatacattt ttacaaagac gagccatcag 2652421 catgtctgac ggttttgaac aaaaagaaca gaagcctttt aatacaggca gagaggagac 2652481 aatcatggag gaaacgaaac aagttggaaa aggcattctt tacggcttaa tcgccatatt 2652541 ttcagccatg ctcctgacaa gtttagcggt ttcactttta ttgaccgcaa cctcgctgga 2652601 agaatcatca tttaactggc tgatcaccgc tatctcattt ctctctttat ttatcggcgg 2652661 gttcatttca ggcgggaaag gcaaggaaag aggctggatg attggcgcat tgaccgcctt 2652721 aagtttttct ctgattatct tattgtttca gtatttagga ttcggaaaga catttacagc 2652781 agaacagctg atcttccatc tgggattttt aggggtgtgc atgctgggcg ggattttcgg 2652841 cgtgaacatg aggggaaaca ggtcttccac ataaaaaaga gcgggctcac ttgcccgctc 2652901 ttttttgttt gctatgtata gctcctgctg ttattcagca gcagaaactt ctctgatcgc 2652961 gcggcggtcg aacgtaagac gtgtgttatc accagtctta attacgactt tgctttcgtc 2653021 gatagagtca acagtaccgt gcaatccccc gattgtcact actgaatcgc cttttttcag 2653081 ttcctcttgc atttggcgta cagccttttg ctgcttttgc tgaggacgaa tcagcaagaa 2653141 gtaaaggacc gcaaacatta aaataatagg aaccaatgta cctaaagtgc cagtcatcat 2653201 tttcacccct ttctgtaagc ctgttatgtt tatttagaag cttttcgcat ttggcttgtt 2653261 atagccgtaa cgctcaaaga actcttctct gaaatcaccc agacgatcct cgcgaatagc 2653321 ctgtcttacc tgctccatta agtgtaacag aaaatgaagg ttatggtaag ttgttaatcg 2653381 aaggccgaat gtttcattgc agcgaatcaa gtgcctaatg tacgcgcgag tgtagttttt 2653441 acatgtatag caatcacact cttcatcaat cggacggaag tctctttcaa atttcgcatt 2653501 tttcatattg agtcgtcctt cagcagtaaa cactgtgccg tttcttgcaa tccgtgtagg 2653561 cagcacacag tcaaacatat cgaccccgcg gatcgctccg tcgatcagtg cgtccggaga 2653621 acctactccc atcagatatc tcggtttatc cttcggcaag agcggtgttg tgaattcgag 2653681 tacacggttc atgacatcct tcggttcacc tacagacaat ccgcctatag catatcccgg 2653741 aaaatcaagc gaaatcaagt ccttcgcact ttgtgtccgc agatcttcat attctccgcc 2653801 ttgtacaata ccaaacagcc cttgttcatc ctgacgattg tgggcattca ggcagcgttc 2653861 cgcccagcgg cttgtccgtt caactgacct cttcatgtag tcgtactccg ccgggtatgg 2653921 cgggcattcg tcaaacgcca tcataatatc agagccgagt gcgttttgga tctccatcgc 2653981 tttttccgga gataaaaaca gcttgtctcc atttagatga ttgcggaaat ggacaccctc 2654041 ttcctctata ttacgaaact tgcttaaaga aaagacctga aaaccgcctg aatctgttaa 2654101 aattgcgcgg tcccagttca taaatttatg gagcccgccc gcttctttga caatgtcttg 2654161 gcccggacga agccatagat gataagtgtt gctcaaaatg atgcctgcat ccattgcttt 2654221 cagctcttca ggcgacattg ttttgactgt cgccagtgtg ccgaccggca taaaaaccgg 2654281 cgtttcgaag gagccgtgag gcgtatgcac tttgcccagc cgcgctcctg tttgtttgca 2654341 ttcttttata aattcatagc gtattggttg ttcagccact tttgatgagg cctcctgttc 2654401 tcaaattata taatcagcat cgcgtctccg aagctgaaga aacggtattc ctcttccact 2654461 gcatggttat aggcacgcag aatgttttct cttccagcaa gcgcgctgac cagcataatc 2654521 aatgacgatt tcggcaaatg gaagtttgta atcattccgt caatggcttt aaattcatag 2654581 cccggataaa taaaaataga tgtccagccg cttgatgctt taaattgccc gtcatgttct 2654641 ccggcaatcg tctcaagcgt gcgtgtcgag gtcgtgccga cagaaatgat ccgaccgcca 2654701 ttttctctta ctttgtttaa ggctgcagcc gtttcttctg acatttgata aaactctgca 2654761 tgcatattat gctcttccac ttcatcggca ctcacagggc gaaacgttcc aaggcctacg 2654821 tgcagtgtga tgaactcaat ttgcacgcct ttgtctttca gctgctgtaa gatttcttcc 2654881 gtgaagtgaa ggccagctgt aggcgcagca gcagagccaa tttcttttga atacactgtc 2654941 tggtagcgct ctttgtcatc aagctgttct ttgatatatg gagggagcgg catctctcca 2655001 agggattcaa gcacctcgta gaaaataccg tcatattgaa attccatctt tctgccgccg 2655061 tgctcaagct cttccgtgca gattgccttc aatcttccgt ctccaaatgt gacaacagtt 2655121 ccttttttca cccgtttcgc cggtttggca agtgtttccc atttatcacc ggtttcctgt 2655181 ttcaacaaaa gaagttccac tttcgcgccg gtatcctctt ttgtgccgaa taaccgcgca 2655241 ggcagtaccc gggtattgtt caggactaga caatcgcctt cgttaaagaa gctgataatg 2655301 tgtttaaacg agctgtcagt aagctctcct gtatgtttat cgagcaccat cagccttgaa 2655361 gcatcacgct gctccaacgg tacttgtgca attaaacgtt ctggtagttc aaaatcaaat 2655421 aaatcgactt tcatgatgat ttcaccttta ttctagtctt ttgttatttc attctgccaa 2655481 aaagattaag caaaattgat aataccacac ttataataat acaagtgaca accgggaaga 2655541 aaaacgtaac atttcctttt tttacaaaaa tatctcccgg catcttgccg acaaaatgca 2655601 aaactgctcc gataataagc aaaacagcac caagaatcat aatgatctta ggaaattcag 2655661 tcatatcggg gagcctccat ttggaaatga tgataaacgg ccggtgtcac gatccttcca 2655721 cgcggcgttc tttgtataaa tccaatttgc agcagatatg gttcatatac gtcttcaatc 2655781 gtatgcgatt cctcgccgat ggtagctgaa atcgtatcaa ggcctactgg gccgccgttg 2655841 aatttttcga tcatgcccat cagcagctta tgatcaatat gatccaaacc gaggcggtca 2655901 acctgaagcc gctccagcgc attctgagaa atgtcttccg taatcctgct gtcacccagc 2655961 acttgggcga aatcgcgcac ccttctcagc aggcggttcg ccacgcgggg cgtccctctc 2656021 gatcttcttg caatttcaag agccgacggt ttatcaatct caacctcgaa tacatcagcg 2656081 gttcttgtga caatatccgc cagttcttct tgtgtatagt actcaaggcg agacattacg 2656141 ccgaatctgt ctcttaaagg agccgtcaaa agccccaccc tcgtcgtggc tcccaccagc 2656201 gtaaaaggcg gaaggtcgag gcgaaccgag cgggcagatg ggcctttgcc aatcacaatg 2656261 tccaggcaaa agtcttccat tgcaggataa agcacctctt cgatcgatct gtgcagccta 2656321 tgtatttcat caataaataa tacatctccc ggttccagcg ccgttaatat agcagccaaa 2656381 tcaccaggcc tttcaatcgc aggccctgat gtcgtccgca attccactcc catttcatta 2656441 gcaacaatcg aagcaagcgt tgtttttccg agtccgggcg gcccgtacag aagaacatga 2656501 tccagcgtct cctgtctcat tttcgccgca tctataaaca cgcgcaaatt ttcttttacc 2656561 ttatgctgcc cgatatactg tgccagattt tgcggcctca ggctttgctc tatcactgat 2656621 tcatggttgt ctgcttcact tgagacgagc cgttcatcca tgaacatcac cttactttaa 2656681 tagtttttgt aatgcttttt tcacatattg gtctgttgtc agcccaattt cttctttaag 2656741 gtgaggaagc acctttttga tttctttttc agcatatccg agaaccctga gggcttcaag 2656801 tgcttcttca agagccgttt ccgctgtttg cttttcaagc ctttcttcat gattaaacag 2656861 attttcaatc atttcaggca caacatctgc cagctttcct tttaaatcta gaataatctg 2656921 gcgtgcggtt ttctttccta ctccaggaaa cttgaccaaa aaagcttcat cttcattttc 2656981 aattgcttgg atgaccgctc cgggatcacc cgagcccaag atggcaagtg ctcctttcgg 2657041 gccaattccg gtcacgttta acagctttgt aaagagcgcc ttctcctctc ttgttgaaaa 2657101 accataaagc gaaaaagcat cctctctgat atgatggtat gtaaaaatcg tttcttggct 2657161 tctctcctta tatataaacg gattcggcgt gaaaatctga tagccgatgc cgccgttctc 2657221 tatgacaata tattggggag atacataatc aatcgtccct ttaacaaatt caatcacgca 2657281 aattcacctc tttgactgtt cttcattgta ccataaaaac agccaaagtc ttatagaaaa 2657341 gttaacatat gttcgcttct ctctcattct ttcacgaaaa aaaagacatg aatacatgtc 2657401 ttcaatcagc ggacgctacc cgctgtatgt cttcatatgt tcgatgacat cctcaaactc 2657461 cgcttttgtc cgaaatggaa tgcctttcag cagatttttt tgcatatggc tttccagcct 2657521 ttctaaatca atttgaaaaa aagactgaat tggttcggaa gctggctcag gccgcccatg 2657581 aaaagtggaa atcactccat tatccgatac accgatatac ccgttgacct tgctgagcgg 2657641 agaaatatcg tccatttgct tccggaagag cacatatccc tttttttgtt ccactagcgt 2657701 ccatccggca taagctgccc aaaaatcatc catagaaaac actttttcat gcttatgctc 2657761 aatgctgaca tcgccgtcca aatacacctt ttcaagctgc acatgcacct gcagcggctc 2657821 atagtgctcc acttccgcgc caagtgcgcg ggaaggagct cctattaaaa atactgccgc 2657881 tgagcaaaga atgcccagca aaagatacgc cgtgctgaat cgtttcaccc tctacacctc 2657941 tttgcacacg tttatgatta gtttgaccaa agaggctact gcttaaccgt tttatcaaaa 2658001 tttgtctgca cattttccct gacaaaccgt tcctccgtat acacatctgt gctttgctca 2658061 gaaattgtca agaatcgcgt cagaaaggca ctgaaaaaat acaatgccgc aaagatccaa 2658121 atcacgccac ctgcaccgag cggcccaatg aaaagactca cgatgcccgg cgcgataaac 2658181 gcacataaac cagatcccaa attcaacact gacatggcag cacctttatt atcaggtgca 2658241 agcgtcggca aaagcgcgct taatgggacg taccctgcta aagccgcgcc gtagcagcag 2658301 gcgataatca tgagcaccca atactgatgc ccgatcagct gaggcgtgta atacagcgcc 2658361 agcgtaaaaa taccgcatcc gacaccgcca aaccacatga ccgtattgcg ccagcctagt 2658421 ttatctccga ctgcaccgaa aatgatatta aacacaatat tcacaaaaaa cagcgtcccc 2658481 catatttgca gccattccga aaccgaatac ccgtatcgtg ctaaataagt aggaagaaag 2658541 atggcaaatc caaattgtcc tatcgcatta atcgtcttga ccactccgcc gatgcctacc 2658601 ttagggtttt caaacataat cgtaaatgcc ttcgacagtt ctttccattt cggctgatct 2658661 tgtttttgta tcggagtaaa tttatctttg ttaaaaaata aggcaagaat tccgcctgcc 2658721 gccacaaaca gtaaagcgct ccaaagcgta ttgatttctc caaaggccgg aactgcatag 2658781 ctggaataga acggaccgag cacgttaagg ccgcacgtaa acataaacca aaaccagccg 2658841 acggcttttc caagaatatt ttgagaggtg ctgtatgaca cccatacgag aaaagagtat 2658901 gcaaacagcg gatatcccaa gcctctaaga gcatagctgc ccaagagagc cggataatac 2658961 atatgaggaa tcgcccagcc gataaaagcg gccgaaccga ggataaatgc aagcaatccg 2659021 acagtcatcg tttttctcgg cccccaagtt tggacaaacg ttcctgaaag ccaagctgag 2659081 atggtgacag caatgccgta catggtaaat aacgatgcgg attgctgcat actgagacca 2659141 tgatcaacga gaaaaggaga cagccagcct tgttcgaggc cgtctccaac cataaagatg 2659201 acaacgccaa tataacccca aaccatgtga gaaggaattc cgattttgtt caaaacattt 2659261 cctttagcat gtactgtatt cattttctcc accgcctact taaagtatca atggagtata 2659321 tacccaagct tgctgaattg taatcctgtt agattaaaaa gcgatttttt cagtgtgctc 2659381 aatgctaaca ggcatgccaa aagcaagcga ttgctgtgct gctctggcga tcctcccggc 2659441 ctgtaaaccg tcattgccgg tgcagggagt ctcctggttt gtgccgatcg cttctgcaaa 2659501 acggagaatc tcctcctcat atgaatcctt atagcgttca aggaaaaaga aatgcggttt 2659561 atccttcatc acaaaatcag ctgttgacac ctcaaccgtt gtcggcctgc tattgtcagc 2659621 cgctgcagag cctttcgtcc cgaaaacctc aacccgctgg tcatatccgt acacagcttg 2659681 gcggctgtta tcaatcacag ccatggcacc gttttcaaaa gtcagtgtaa taacagctgt 2659741 atcaatatca cccagctccg caaaagaagg attcaccaaa gccgcccctt tggcatacac 2659801 ttccgtcact tcgcttccca taatatatct ggccatatca aaatcatgga tcgacatatc 2659861 cataaacaat ccgcctgacg tacggacata atctatattc gggggttctg ggtcccggga 2659921 cgtgattttt aataaatgag gtgtaccgat ttcaccattt tcaacaatcg ttttgatttt 2659981 cttaaaatga ggatcaaagc ggcggttaaa tccgacttga agtgttaccc cgtgtttccg 2660041 gacagccgca agcgcttcac tcgtttcgtc cagagagaaa ctaacgggct tctcacaaaa 2660101 tatatgcttt ttcgcctcgg ctgcttcttt gatcatctgt gcatgtacgg ctgtaggaga 2660161 gcaaataaaa atagcatcaa tatcaggatc atgtaataaa tcacgataat cagaggttat 2660221 gtattcaatc tgatgactgt cggcccagct ttttatacgg ctcgcctgaa tgtcagagat 2660281 tgcttttatt ttcatgtgag gaatccggct tatattttga acatgaagtt tgccgatgcg 2660341 gcctgcaccg ataatccctg tcacaatctg ttttgtcatg gcttcttccc ccttgatcat 2660401 tcacgaaagc gctttattta aaattaatac tatcccattt gtaagcgctt ttcaagaatg 2660461 gaaattaaac gttctatgtc tcttttatca caattcatgc ttataagtag ccttcttctt 2660521 caagaccaga tacactagaa ttaggctctt tttcctgaac agtttatgat tttcctataa 2660581 acagctgcat aaaatagagc aaagaaggtg aatgaaatgc tgacaaaagc agaggcactg 2660641 gcccataccg tcatataccg caagaacagc agatttgata aagtcaaaga gaaatccgag 2660701 gaattaacac taatcggcaa gggaagaagc gcctatgtgt ttgccttaac agaaggcggt 2660761 cgaaaaatgg cgctgaaagt attttttccg gaatatcaag cgacagcagt caaagaagca 2660821 gcgatctatg aaaaattagc cgggtccgca ttctatcctg acatttacga aactggcgat 2660881 tcatttattc tcatggaata tattaaaggt gaaacctttt ataactgtct gaagaaaggc 2660941 attgcaatca gtgatgacat gattcagcag gttgaagaag cgctttctga cgcccgggca 2661001 gccggactga acccgtcaga tattcatttg cggaatctga tattgacaga aaccggggcg 2661061 gtgcgggtga ttgatgttgc gagatttgag cagacaaaaa catgcacgca gtgggacgac 2661121 ttaaaatccg catatcatgc actctacaaa aaaccgatat tccccaaaaa gattccgggt 2661181 ttttggctgg agatcatcgc atttttatat aagaaagatt ggtttcaaaa gcatttcgca 2661241 cagcggaaaa gaaaatattc ttaaatcaaa aaggcagccg cacaagcggc tgcctttatc 2661301 atgtattttt tactttctga cggcagaaat cagtttcatt tgttcaggcg acagcttaat 2661361 tcgatagcct ctcacagtta agtagaccgc ttctgggtcc ttctcgccgg aatgacaata 2661421 cgttttttcc atttctgtct cccctcaccc tttattggct ttatttcatc ttatcattgc 2661481 tttattgagg taattttaaa gaaatgtaaa gattatatga atccgatata tagtaaaatg 2661541 agagaaaaaa agggagagag tcacattaag accgaaaaca ccttgagctt agatgcagcc 2661601 agaggtgaac ttgtaaatga aaaaacactt gtcaagagaa caatctactg gaattacccg 2661661 gacagccgcc cagcagtgac gtggatcaat cacaatacag tgaaaatcgg caatcagact 2661721 ttacatcttg atactgatga aacgtatgat tggcgaaaag atgatcattg gatccgtgaa 2661781 gaaccgccgc aggcgtcagt gaggtgatga aacatgaata agatgaacgg aacaaatgat 2661841 gaaaagcatt tcaatcattt tgtgattgct ttatccttta tatacggttt gactgaacta 2661901 ggctatttgt tgctgaagga ttttataaca attgccataa gtttgcctct gtagaaaaac 2661961 gcagcgtagt cgatacgccg cgttttttct ttttcccttc ctcttcttat tgataattac 2662021 aggtcatata atgtgacaaa tcgattgtag aaatagttcg attagaccaa aatccttttt 2662081 atacatgtat tcgaatttga agtgaggggg aagcttgatg gcagattttg ttgctagttt 2662141 gaatgcggtc ttatggagta cgcccgtcat ttatatttta ttgggaattg gattcgcctt 2662201 ttcaattatg acccgttttt tacaagtccg acatttaaaa gaaatgattg ttcagatgtt 2662261 caaaggcaag agctctgaag ccggcgtttc atctttccaa gcgttatcga ttgcgctgtc 2662321 cggccgtgtg ggcacaggaa acatcgcggg agtggcgaca gcaattgcat tcggcggacc 2662381 cggtgcagtg ttctggatgt gggcgattgc ctttatcggg gcggcgagtg cctttgtaga 2662441 atcaacgctt gctcaaattt acaaagtgaa acaagacggt caatatcggg gcggccctgc 2662501 ttattatata gaaaaaggct taggcattaa gtggtttgcc gtcttatttg ccgctgctgc 2662561 ccttattgca atggcctttc taatgccggg cgtacagtcc aactccattg cggctgggat 2662621 ccaaaatgca ttcggcatct ctcctttcgt cacagggtgc ggtctggttt tattattagg 2662681 gttcattatt tttggcggcg tcaaacgaat tgccaatgcg gcgcaaatga ttgttccatt 2662741 tatggccatt ggatatatcc tgctgtcttt gattattatt gtcatgaatg tgtctgaatt 2662801 gcctgctgtg atctcattaa tattcaaaag cgccttcgca ttggattccg cttttggcgg 2662861 cttgatcggt atggcgattt cctggggcgt taaacgtggc atttactcaa acgaagccgg 2662921 ccagggaaca ggcccgcatc cggcagctgc tgcagaggtt tctcatccgg tcaagcaggg 2662981 actggttcag gcattttctg tttatattga caccttgttt gtatgttccg ctacagcttt 2663041 catgatcttg tttaccggca tgtacaatac ccaggctgca gatggttcct ttatcgttca 2663101 ccagcttaaa ggcgtagaag caggacctgg tttcacacaa gcggcaattg acagtgttct 2663161 tcccggattc ggtgcaggct ttgttgccat cgctttattc ttcttcgctt ttacaacaat 2663221 tatggcgtat tactacatcg cagaaacaaa tatcgcctat ttagcacgag gcagagaaag 2663281 caaatgggcg atgcttggct taaaactgat tattttagcc gccacgttct atggtactgt 2663341 gaaaacagct tcacttgctt gggcattagg ggatgcaggg cttggcatta tggtatggct 2663401 gaacgtcatt gccattgtgc tgcttgccaa gccggcgctc cttgctttaa aggattatga 2663461 gcgccaaaag aagcagggct tagacccgat ctttgatcca aaagcgctgg gtatcaaaaa 2663521 cgctgatttc tgggagaaag aatacactca tgaaagtgaa cgtgtctcct gaacatacta 2663581 aaaccggccc gatatgacct cgtgccggtt ttttatgaac gatagtttgt atacacttct 2663641 tgaacatcat cgtcatcttc aaggacgtct attaatgttt ccagcttctc aacagcctga 2663701 tcatcggctt ctgcataggt attgggaagc atggtcacct ccgccgaaga aattagatat 2663761 ttcgattcga gggctgtttt cacctcttca aaatgctcag gctctgtgaa aacctcatat 2663821 aggtcttctt caattcgcag ctcttctcct cctgcttcaa gcacatcaag catgagctca 2663881 tcttcttcta tttgccgttc agtacggtct atcgtaatga acccctttcg ttcaaataaa 2663941 aaggctacac atccgctttc tcccagactt ccgccatttt tattaaaggc tgtccgcaca 2664001 tttgacgccg ttcggttttt attatctgtt acgcattcaa ccatgacggc aatccctgaa 2664061 gggccgtagc cttcataggt gatttcttca tagctgcttc cgtcttggcc tcccgcagct 2664121 tttttaatgg cccgatctat attttcattc ggcatattgg cgccttttgc tttttcgatg 2664181 acaagacgca atgctgaatt tgcttctgga tccgctccgc cttctttcgc tgccacatag 2664241 atttcttttg ccagcttcat aaatattttc ccgcgctttg catcctgtgc attttttctt 2664301 ttttgaatgt ttttccactt ggaatggcct gccatgtttt caccttcttt tacattttct 2664361 atgtacactt taatgggaaa tgttcgctga tgcaaagaaa aaggctgccg aatatcactt 2664421 ccggcagccc ttccttccta gcggttgttc attttatgaa gttttctgaa cagcccttta 2664481 tctgttgata cttggacgtc acggccattt gcatagttgc gcgctgcttt tacaacatta 2664541 tctctgtcag actttgtgaa ctctctgtgg cttttgactg cgataactac tcggtcatcc 2664601 gataccataa cttgtgtgtc attgacgttt ttcacttgtt tcacacggtt ggcaattttt 2664661 gcagccagtc ttctgttttc ttggttgtca tacccgttgt tcgctgcatt ccgattcatg 2664721 tttcggttat tcgtgttgtt atatgttccg tcagttgcca aaggaacacg atcgtcagca 2664781 gtaacacggt cacggttatt tacattcgtg gtgtttcggt taccgtcgtt ctgatcctcc 2664841 attaattcag aaacaggacc atcgtggtcg attccgtctc cctgtctatc ggcgtcattt 2664901 tcatttgtat aatatccgat tggacgggta ttgccgttat tgcgcgtatc attcatagca 2664961 ttatcgtttg ctccgcatgc tgttaagccg gctgtcatta gaatcaggct agcgatcgtc 2665021 atttttttac ccaatggaaa aaccccccgt ggacgaattg agcatgtttg ctcgctttta 2665081 tcatgtgcgt atggggggca tgttaagcgt gtcagttctc tccatttggc agtgatctgc 2665141 ttgaaaacaa aaaaaggaac gatttacatc gttccgaacg atcactcatt ttcttcttcc 2665201 ggacggccaa acatttggtt tacagaaggc tggttcgtca ttggcataga aactcctgcc 2665261 gaatatgggt ttggatttgg gttagctgtg ccatatggca tattagggct tccataagct 2665321 cccattcccg aatggccagg tgcagagaaa tatggctgat gatcaccgtc acagccgcag 2665381 tcgtcatgat ctttgtatgg catgtaacca tgagccgcag caggctggta tgctcccatt 2665441 acttggggag tgccgtaata agggccatac ggcatatgtc catacggaga tccataagcc 2665501 ggagatgcgt attgcggcgc accgtatgaa ccgtaatgtc cgtgatggct gttttcatga 2665561 tgctggtttt cataacccgg gtcatactga ggcgatacaa agcctggctg gtatccatgc 2665621 atcggatgca ttggataagc ttgtgccgga tagtacggat agcataatcc tgatcctgga 2665681 agaattggcg aaacaggcac cggacacggt acgaaatgag ccggataatg ataataaggc 2665741 tgaacagccg gcatcggcat attcggaact gtgtgatgaa cgttttcctc ttctataccg 2665801 cctacctctg gcgcctttgg catattaggc atattcggat aatttgcatt ttccatatta 2665861 ctcatagcct cctgttgtgg aaattggtct tgcatatgat acatatgatc catatttccg 2665921 tcatgatgtt ttttcggctc ctccggttta ggaggcgacc aaggctggaa aagctgtttc 2665981 atatcataat aatcgttcac atcagcttca gggtacacat tttcctgcaa attaggcatc 2666041 ggcgggacat acggcatgga cttcttttct ttcggctttg tgtcttctac atcgacaacg 2666101 gatttaggct tctctttcgc atatggatgt tcttgcttca cactcccggc cgcaggactt 2666161 ttgcccgctt ttggctcttt tctgaccggg actccttctg acggcacttt tattttcatt 2666221 ccaggcatga ttaagtctgg attgctaagc tgtgtattga gttttttcac ttcctcaaca 2666281 tcgactccgt acttttcagc tattttccag agcgaatcgc ctttttgaac gatatggatt 2666341 ttcaacgttt tcccctccta tgcaaaacgt gaacagttca gctgtgatta caatatgttt 2666401 cttcacaaca tatgcctgaa caaaagaagt tatgagtaaa ggaagggaaa atatttctga 2666461 tctacgtgat cgaaagcatt cgattcaggg caaggagtgc atcttcctga atggcttttg 2666521 gcaccttgat gacgcctgaa ggttctcctt tttcaatttg ttccagcgac cacaacaaat 2666581 gcggcaaatc aattcggttc attgtcaggc aagggcacat gtcagggttg agtgattcga 2666641 tttgtttatc tggatgctcg tgaatgatcc gctgaacaag attcatttct gtcccgattg 2666701 cccacttgct tcccgccgga gcctggttga ttgtgtcgat aatatatttc gttgatccgt 2666761 tatcatcgct tagtgtcacg acttcgtgtg aacattccgg gtgcacaatg atctgaatgt 2666821 cggggtctcg ctctctcata tcatggatat ttttagtggt gaatttctcg tgaacagagc 2666881 aatgcccttt ccacaaaatc actttcacat tcgtatgccc ggattcagct actaattcat 2666941 ctttcatcgg atcccacaca gccatatctt caagcgcaat gcccagatca taagccgtat 2667001 ttctccctaa atgctgatca ggcaaaaata aaattctttt tttctgtgta aacgcccatt 2667061 caagcacttt tttcgcattc gaagaagtta cagttgctcc gccatgcttt ccgacgaatg 2667121 ccttgatctc cgcagtggag ttcacataag ttaaaggtat gatcgtatct ccaaatatat 2667181 gctgaagctt cttccatgcc ctattggtct gctgcatgtc agccatgtca gccatagaac 2667241 atccagctct catatctggc aggacgaccg tttgctgctc gcttgtcagc atatcggcgg 2667301 tttctgccat aaagtgaacg ccgcaaaata cgatataatc cgcttctttg tttttttccg 2667361 ctacttgggc caattgcagg gagtcgcctg tttggtcagc aaattgtatc acttcatcct 2667421 tttgataatg atggcctggt ataaagagcc tgctgccgaa ctttttctta atggcggcaa 2667481 cgcgcgtttc catatccttt ctcgatagtt ctttataact ttcgggcatc atatcattcg 2667541 attgtttgat cacatcaaga attgacataa cagcattcct ccacagattc atttgataac 2667601 gtaacatcca tgctgatatc taaacttttg acggaatgag tcagaaatcc taatgaaata 2667661 taattcacac ccgtcccttt aaaagcaggc aaagattcta acgtaatccc gccagaggct 2667721 tcagttttta tattagccgg tgtgagcttt gcaaaatgac ggaccgtatc aggcggacag 2667781 ttgtcaaaca taataacatc cgctccagct gcaattgctt cccgcagctg ttcctccgtt 2667841 tcaatttcca cctcgatatt taccatgtgc cctgcggcct gacgggcttt tttgcacgcc 2667901 tctaaaatag agccgcatgc tgcgatatga ttatctttaa tcatgatgcc gtcatacaaa 2667961 ccgaatcgat gattataccc gccgccggct ctgacagcat atttctccag cattctgagc 2668021 cccggtgttg tttttctcgt gtcacaaatt ttaatctgtt catcatccag acaccgaaca 2668081 gcctctcttg tcattgtcgc aattcctgac agcctctgaa taagatttaa tacgacccgc 2668141 tctcctgaaa ggagcgcagc tgcgggaccg tgtaactcgg caatcacttc acctttatgc 2668201 aacatgtccc catctttttt gtgtaaaatg ctttgaacat tttcgtccaa taacgaaaag 2668261 ccttctttta tgatcgctgc tcctgcaaaa ataccctctg actttgcaac aatctccgct 2668321 tcacagctct gttctccaaa aatagactgc gatgtaagat cccctgtccc aatatcctca 2668381 agaaaaaagt gattcagtaa ttttttcagc tgtaaatgat tcattgttcc aaatcccctc 2668441 gttttttctg atcttcgttc ctttttttgt atggacaatt tgtcttcctt gccagctcac 2668501 ctcagcatga ggaaaatcgg tgcggaagtg agcccctctg ctttcctccc gcaaaagcgc 2668561 agaaaacgtc atcagctttg cagtttgcca tagatgagaa agttccatct gccgaattgt 2668621 gatatccttc acatttactt cctgaaaagg cagcgtatga agccagatgc taagctcaat 2668681 caaactgctt tgttcccgca gaatagacat gtggcttgtc attttgcttt gcagttcatg 2668741 cccctctata tccggcacct cgtagaagac actggtttct agccctgatt gatattgcct 2668801 gttataaacc ggtttttgga taatatgctc tgctgccctt tttccaaata ccagcgcttc 2668861 caataaagaa ttgcttgcaa gccggtttgc tccatgtaaa ccggagcatg ctgtctcgcc 2668921 aatcgcataa agccccggca ctgtcgtttc tccccagcga ttaactgaaa cacctcccat 2668981 taagaaatgc attcccggag caacaggaat ttttccgctg tggatatcaa tccctgcttt 2669041 ttcacaaata gcggtgatgg tagggaaacg cgtttcaaaa tcagaaatcg cactgaagtc 2669101 tatataaacg cgatttcctt ttgccatttc ttcgtgaata acccgtgaga caatatctct 2669161 tggagccagg tcacctaaag gatgccgttc agccataatc ctgcggccgt tttcgtctac 2669221 taaacatccg ccttcccctc tgacagcttc tgaaacaagc ccgtaggaaa caccattttt 2669281 cacaagcagt gtcgggtgaa actgagtaaa ctccaaatcc gttaattccg ccccggcccg 2669341 gtaagccaga gaaagaccgt cacctgtgac agtgagatca ttcgtatggt gaagaaacag 2669401 gtttccacag ccgccggcag ccagcacaac ttcgtctgcg tgccttacct tgagccgccc 2669461 tttgctgtct tttgtcatga cgccgataca tcgtccgtcc tctataagca aatctgctgc 2669521 cgtttcattc tcgattaact tgattttgct gttgatccgt ttgagcaaat aatcgataag 2669581 cagcctgcct gttgcgtctc cgcctgcatg aaatatgcgg ttgtatgagt gggccccttc 2669641 tcttccaaga caaacaccgc ctcgttcatt gcggtcgaat ggaaatccac gctccaatag 2669701 gctttgaacc atcatttttc catcatgtaa tacgtctgct acaatagcta gattattatg 2669761 gccgcaccct gcgtataacg tatcctccag atgggcttca atcgagtcat cttttgcata 2669821 ggccgcagca atcccgcctt gtgcatagac agaattgctg tttttgacgc ttttttttgt 2669881 gataacagtc acttcgtatg agggcgggaa agctgcagct aaggaaagtg ccgccgcccc 2669941 tgaaccgatg actgcaatcg tctttttaga catatgccat cctcctgttg tttacacctg 2670001 tcttgacacc tatatttaca caaggataaa ataaactcaa gagtttttta tggagaacgg 2670061 atggaggaag accggatgat ttatttagat tatgcagcga caacgcctat ttgtgaggaa 2670121 gcccttactg tatatcagaa gcttagtatg gatatgtacg gaaatgccag cagcctgcat 2670181 gatgcaggag gaaaagcaaa gcacatactg gagtactgcc gtgaaaaaat cgccaacatc 2670241 attggcggag aagcaagcgg catctatttt acaagcggcg gcactgaatc caattttctg 2670301 gccattcaat cattgttaaa cggcctgcca aaaacgaaaa gacattttat tacgactgcc 2670361 atggagcatc agtccattca taattgcgct gcttttttgg aacagcaggg atatgatgta 2670421 acagtcattg aaccgaatga atacgggctt attaccgagg aaatattact aacccatatc 2670481 cggccggaaa caggccttgt atctattcag catgcaaatt ctgaaaccgg gatcattcag 2670541 cccattcaac acctgtcttc atacctgcac aataagggga ttcttcttca ttgcgacgct 2670601 gttcaaacgt ttggaaagat cccgatcaat acaaaaaatc tgggagtaga tgcactctca 2670661 atgtccagcc ataaaatcca cggtcctaaa ggagtagggg cggtctatat ccggccggat 2670721 gtcccttgga aacccgttta tcctctgact actcacgaat acggattcag agccggcacc 2670781 gtaaatgttc ccgggatcgg tgccttcact gccgctgcag aattgatcgt aagcgaaatg 2670841 gaaaaacaga tatcccgcaa tgaggcatta agaacatact ttctagacca aatccgtatt 2670901 cggtctctcc ctgtaaccct tgcagcagac acttcgaaag cagaatgtct tccgcatatt 2670961 atagggtgtt tttttcactc atttgaagga caatatgtta tgttagaatg taatcggagt 2671021 aatatttgca tttcaaccgg cagcgcttgt tctgcaggtt accacggtcc gtctgaaaca 2671081 atgaaagcat taagaaaaac cgaacaagaa gctctgcaat ttatccgcat ctcttttggc 2671141 aggcatacaa cagctgaaca gctggaacag ttattacata cgtttacagt gctttgggaa 2671201 caaaagaaag gagaatttga tattgaccga agaattaaag ctaatgggcg ccaacaggcg 2671261 tgaccagctt cttctgtggc tgaaggaatc taaatcaccg ctgacaggag gagaactcgc 2671321 aaaaaaagcg aacgtctcaa gacaggttat tgtacaggat atatcgctct tgaaagcgaa 2671381 aaatgtaccg attatcgcca caagccaagg atatgtatac atggatgcag ccgctcagca 2671441 gcaccagcag gcagaaagaa tcatagcatg tctgcacggt cctgaacgga cagaagagga 2671501 actgcagctc atcgtcgacg aaggcgttac agtaaaagac gtaaaaatcg agcatcccgt 2671561 atacggagat ttaactgcag ccatccaagt aggcacccgg aaagaagtta gccatttcat 2671621 caaaaaaatc aattctacga atgctgccta cttatcacag ctgaccgacg gcgtgcacct 2671681 gcatacactg acagcacctg atgaacatcg catcgatcaa gcctgccaag ccctcgaaga 2671741 agccggcatt ttaattaaag actaaaaaaa gccctctagt gggctttttt tataattggt 2671801 aagactggta tgcacccaga agcctcactt tgcagccgag tgcttcaagc tcctgcatgg 2671861 cccctggaat caatacatca tcaaacgctt tctcaatatc aataataaag aaataatggc 2671921 ctaatccggt tttagtcgga cgtgactcaa tttttgacag gtttaaattt ctccaagaaa 2671981 atgcagacag cactctatgc agcgccccgg actgatcatc ctgcggcagc atgaccatta 2672041 aggtcgtttt gggcctagag ctcaattttg aattcacttc aaaagatatg ttttcatcgg 2672101 gagacaggat aacaaatctt gtatgattgt ccctataatc ctgtatatcc cgtttcacga 2672161 tttttaattc gtatgtagaa gctgccatat cattggcaat gaccccgata ttcagctcgg 2672221 gatggtcact gacaaacttt gctgccgccc cggtagaatt ggcgtattca tatggaacgg 2672281 aaggaaaatg tcgatgaaga aatttatggc attgcgcaat cgcgtgtgaa tgtgagtaaa 2672341 ttttgtcgag ctctttccat gcattctctc ttgagggatg gacgagcaag tgctggtgaa 2672401 tcggcaacgt catttcaccc acgattggca aaggctgttc atgtattaaa tagtctattg 2672461 ttagattaac agatccttct aaagcatttt ccaaaggaac aaaagcaaaa tcaacttcgc 2672521 ctgcaacggc tgcatctata cactccggaa tggtgcggta agcaacatgt tcggcgccgt 2672581 tttgaaaaca agaactgact gctagatgtg taaatgtagc tgctggacct aaataaccga 2672641 ctttcatgac gattttctct cccttatgca cctgaaccta atatttcaac cttttctaca 2672701 aaatcaaact tcctgagctt attcattaat gtatgaatgt cttcttccat tgccgacgta 2672761 ctgatagaca gtgtcacatt tgctctgcct tgaagcggaa tggtctggtg aatggaaaga 2672821 acgttgcttc cagaatcagc taccgcctga agaagctgag ataacgcacc tgacctatcc 2672881 tccaaatgaa agaaaagtgt gataatttgt tcttttacca tggtgtagaa tggaaaaaca 2672941 gcatccctgt atttataaaa cgcacttcta cttaaatcga ccttttgaac ggcatctgct 2673001 actgaatctg ctttttttcg atcaagcagc tttttgactt ctaatgtttt tctcattgca 2673061 tcgggcaata catcttcacg gacaagataa aatgtctcct ctttcatttg catcccccct 2673121 ttaaaataga gagcctggca ccaggctctc ttttcagcca acattgatta atcaataaat 2673181 tcaaattcaa attccagaag cctgattata tctccatcct tggctccgcg ttctctgagt 2673241 gcttcatcaa cacccattcc gcgcatctgt cttgcaaacc gtttaaccga ttcatcacgt 2673301 gagaaatcag tcatcttgaa taaccgctca aggctgtctc ctgaaagcac aaatacaccg 2673361 tctggatcgc gtgtaatgtt aaatggcact tcttcatttt ccatcgtgta catgacacgg 2673421 ttttgtgtaa gctcttcctc gtcatacagc gggaattccg gtgtgttctc aagctgattg 2673481 gcaacctcaa acagaagctc acgcagacct tctcttgtca ccgcactgat cgggaatacc 2673541 ggataatcat ccgtcagctt ttctttaaag gcttcgagat tttccgcagc ctccggcatg 2673601 tccattttat ttgcaacgat aatttgcgga cgctcagtga gacgcagatt gtactcgctc 2673661 agctcctggt taatcgtaag ataatcatca tatggatcac ggccttctaa gcctgacatg 2673721 tcaatgacat gaacaataac cctcgtccgt tcaatatggc gcaaaaactg gtggcccagt 2673781 ccgacgcctt ggtgtgcgcc ttcaatcagc cctggcaaat cagccatgac aaagctgcgt 2673841 ccgtcatccg tttcaaccat gccgagattc gggacaagcg ttgtaaagtg atagtccgca 2673901 attttcggtt ttgcagatga gacaacagac agcaaagtag attttcccac actcgggaac 2673961 ccgacaagtc cgacatctgc aagcactttt aattcaagaa caatgtagcg ttcttttccc 2674021 ggctcgccgt tttctgaaag ctgaggcgcg ggattagccg gtgtagcaaa gcggctattt 2674081 cctcttccgc ctcttccgcc tcttgcaatg acagcccgct gtccgtgctc tgttaaatca 2674141 gcgatgacct gttttgtatc atcgtctgtc acaacggtgc ccggcggaac tttaatgacc 2674201 atatcatcag catttcgccc gtgctggttt ttggacatgc catgctcgcc gcgaatcgct 2674261 ttaaagtgtt ttttgtatct aaaatccatc agggtgcgga gaccttcatc tacttcaaaa 2674321 acgacgtctc ctccctttcc tccgtcaccg ccggcagggc cgcctttcgg cacatatttt 2674381 tcacggcgaa acgcaaccat accgttgccg ccgtcgccgc cttttacata tactttgacc 2674441 tgatctacaa acataatgtc ctccgttcta aaccgttaaa aactccgcta gtccaaccca 2674501 atttcaatca gacattcgtg actcgtgatt tcaaaacgca tgatatcaac gtcctcatat 2674561 ccattctgcc gaatatcatc aaaagcagat ggatcggcaa aggcgccgtg aaaatcaagg 2674621 tacagaatca gctgtctgtc aggatgatcc gtttgaagcg aaaccgttaa atgattttca 2674681 ctctctctgc tgactgcttg atcaaacaga tgaaacagct ttctcatcag tttcgccagc 2674741 ttttgatcat aagccgacaa atccttaatt tctccgagaa cttcatattc aagcgtcata 2674801 taatgggttt tccaattaaa cgtaagaaaa tcaaacgcca aatgcggtgt tttcaggttt 2674861 gagagctttg attcgtgctt tgcgtctata accatttctt caatcatttc aaagacacgg 2674921 tcatacttct gtaagcttaa gtttccttta atcagctgca gcttattcat ccaatcatgc 2674981 cgggaatggc caagcagatg aatcagttcg tttgttaatg ccgtgtcgct tatattttct 2675041 tcttgatttt ttgaaacatc cttcattttc gcactcccaa tcatttaatt tcttatttag 2675101 gagtctgtat aagtgtgtat tatgaattat aacagagaag gctttgttag aaaaacaatt 2675161 gtttttccca gaaatatcat gttccttttt tctggctttg gttgatttgc agccaggcag 2675221 aacattttat gtattactgc ttggggaaca tatccagtgg gtttgagatg tttattctca 2675281 ttcttggcgg ggtctgctcg cacatactct gcatttcatt ctaggtgttt actccgcata 2675341 ttgcaaaaaa aactccagtc atcatcgacc ggagtttttt gaatcattat tgagctacag 2675401 gatatacgct cacttttttg cggtcacggc cgaaacgttc gaatttaaca gttccgtcga 2675461 ttttcgcaaa tagagtgtca tctccgccgc ggcccacgtt ttcacctggg taaatttttg 2675521 ttccgcgttg acggtaaagg atagaaccgc ctgttacgaa ttgaccgtca gcacgtttag 2675581 cacctaaacg tttagcctca gagtcacgtc cgttctttgt agaacctact ccttttttag 2675641 aagcgaaaaa ctgaagatct aatctaagca tgtagctcac ctcctatatt atgtttgtgg 2675701 tcacacgcaa gttgtctttg taatcccgtt cgattgtctc cagcgaaaca atcatgcctt 2675761 caatcagcag ctgagctttt tggcgtgcct ctggatcaag agattcaggg aattcaaaat 2675821 aaaaataacc cccgtcctct cctatatcaa gaagcggctc gaagcccgcg agcacaatga 2675881 ccgcgttaac ggccccaaac acaacggctg tcactccggc acaaacaaga tcttgtccat 2675941 gttcagcaaa attcgcatgg cccgtcattt caaaagacaa tatgccttta tcatgagacc 2676001 ttctgattgt tgcctgaatc atgcttacgc gttgattttt tcgatcgtca ctttagtgta 2676061 aggctgacga tgaccttgtt ttttatgaac gtttttcttt ggtttgtatc tgaaaacagt 2676121 gatttttttc gcgcggcctt gtttttcaac tttagccgtt actgttgcgc cttcaactgt 2676181 agggttgccg actttcacgt tgtctccgcc aacaaacaaa acgtcttcaa aagtaactgt 2676241 ttcacctgct tcagcagcaa gtttttcgat gtaaacagtt tggccttctt caactttgat 2676301 ttgtttaccg cctgttttaa tgattgcgta cattctctgc acctcctatt agactaagac 2676361 tcgccagata ccagggggct gtaaaagctc ttaacacctg tactgagcgg ttgtagcaat 2676421 ggtgctacat ccataacatt aaaaaatata ccaaaataca aggcgtttgt caatcagttt 2676481 tagtagggca gaagcagttc ctccatggaa gaattcgtcc gcttatcggc aaagtaagcg 2676541 tgcagcactt cattctcgtc aagctggctg agcttttggc ctgatttttc tataataatc 2676601 ggatgcttac agccacgttt gaactcggcc atcacatgat agactttatc ctccgccttt 2676661 actgtcagcg gcagaagttt ctcaagctcc ctgttttttc cgtaatacct ttcgaggaga 2676721 aatctcacat ggatatagtg cctttgccga tattcctcaa acaaggaaac agccagaaag 2676781 acaaacaaaa cccatgcgct gatttgcaga ggaatcacga ataaaaccca gcacccgagc 2676841 agcaggcaga agcagagcga cgtttttaga ttaagccggt gagccttttg aaaaggcagc 2676901 tgtttggaaa acaacaaaaa taacagtttt cctccatcca gcggccagat cggcagtaaa 2676961 ttgacaaata agatagaaag attataaaag gtgaagagtt caaaggtatg ctgatgaatc 2677021 actgagactt ctgcaagcat ccaggcggca aactgaagcc agatgtgctg aagaggtccg 2677081 gcaataatga ccgcaaactc ttcctttaac ggccgattcc cgtgctcttc cacttcgacc 2677141 gttccgccaa acggcagcaa aaaaacacgc ttgattctcc aagaaaaaaa cacagccaga 2677201 gcagcatgcc ccagctcatg aatcaataca atcaggagca gacataataa tgctttcata 2677261 tggcctgtga gcaagcccag cgccgcaata atccaaagaa aaggatgcac atggatcttt 2677321 aagataaggt cgagccattt attcaaatga aatcacctga atcggatcaa taaatttatc 2677381 gccgtctttc atggcaaaat aatagacccc tttattatga tcatcaagct taatcgaacc 2677441 gagctttttg cctttatcca caaaatcata taaagcaaca tccacatctt tgagctcgcc 2677501 atagatacta taggtgttgt cagcatgctg caccttaacc gtcagtcccg tttggctgtc 2677561 tttgctgact tcaaccacat agccttcttt tacgctatca atcttatcac tgcttgtttc 2677621 gactttaatt ccttccccat tgtcctgaaa atcctgctgt actttcccgg atgcaggcgc 2677681 gatcagatct ttgcctactt caatctgctg ttccttattt ttgtgttcag gagccaggaa 2677741 agcaagcgga tttccgaatt tggtttcgaa ccaatggctt gctgaagcaa attgaaattc 2677801 agtttcaaag gttttggcta cggcgggttt aatctgactg acgggtccaa tgtttgtttt 2677861 ataggctata gctgaaacga gaacaaggca ggccgacaga agacatttca ggataattga 2677921 atctgttttc accaatgggt gttttccgtt gaatgttggc atgttatctt cgtagaccgg 2677981 aagtgttcca tgcttttcct gatccgttac catcacccag gacgggggtt tctgcttttc 2678041 agaaactgtc tgagtagaga aacgttttga gccggaaagc tgctttcttc ttttctctaa 2678101 tcgttttctg atttcatctg ctctgtgact cattgccatc atcctttgca ttcgttgggt 2678161 ttgtacatca tatgtcttgt ccatggcaaa tattcggttt agtcaagaac aaagcaggca 2678221 aaaacaaaaa aaacctgaca cagcatatgc tttgtcagat tcttctcttt gattctatca 2678281 cattaagatc ttactccgaa aaatgactta atcttagcca tcattccttt gttttgctct 2678341 tcaagcacct gtaaaggaac agattcacct aagatgcggc gggcaatatt gcgatatgca 2678401 atggaagcgc ggtttttagg gtccatcgca atcggttcgc catgattgga agctttaatg 2678461 acttcatcat catcagccac gattccgagc aaatcgatcg acagatgctg tacgatttcg 2678521 tcgatatcca tcgtgtcacc gtttttcatc aggtgatttc tgattctgtt aacaacgagc 2678581 cgcggcggtt caatattttc ctcttgctcc agcagtccta taatacggtc agcatcacga 2678641 acagctgaga tttcaggcgt agtgaccaca atcgctttat cagctccgga aacggcattt 2678701 ttgtaccctt gctcgattcc ggcaggacag tctatgatga catagtcaaa ttcctgtttg 2678761 agctcttgga ccatgttttt aatttgttca ggagcaacag ctgtcttatc gctcgtttga 2678821 gcagcgggca ttaaatagag cagatcatcg aaacgtttgt cttttacgag cgcctgatgc 2678881 attttgcatc tgccctctac aacgtctacc agatcgtaaa taattctatt ttcaagaccc 2678941 attacaacat caaggttgcg cagtcctata tcagtatcta ctaagcatac gcgcttccct 2679001 aaaatggcta aggcggtacc gaggttcgca gatgttgttg tcttacctac tccgcctttt 2679061 cccgaagtta ttacgatagc ctcacccaat tcacattcct ccctcaagcc ttgttagatc 2679121 aggtcttaaa tgagccaaat gttgaaggcg ttcaatgacc atatttccgt ctgtatctaa 2679181 ataagcacat tccatttcgt tccctttttg aatgtggtct ggggagcgat ttaacacatg 2679241 attgattctt aattgtgtcg gaagcatttc agaggcggcg atgaccgctt gattatttcc 2679301 attgaatcca gcatgcgcaa ttcctttcag tgagcccaga acaaaaatgt tccctccggc 2679361 cctgactgtt ccgccgggat tcacgtcacc gatcaggagc aagtcgcctt ttacctgcag 2679421 cacttggcct gaacggacaa tttttgaaac agaaataatt tcggcttcct ctcttatctg 2679481 ctgtgcttct tttttagtaa tgacttcact gtcaatagaa tgaacaaaca aatctttctt 2679541 tgacgcaatc aattcggtta gctgttcctc ttgctcctta tataaaaagc gatttcccag 2679601 cttaacatga acgctgattt tctggccttt tccatcggta tattgttcaa ttgacagcat 2679661 attctgaaga ccatcgagaa gctcatcaaa agaacacgca tcatccagat gcaatgttag 2679721 tccattcttt gttcctttta ttgttacata ttgctgcttt ttggtcttca caatattcac 2679781 ctcaacaaca tactcatttc gtcaaaaaaa gataaaatcc tttttactca tctctcaatt 2679841 ctttctttag actcataaaa aacaatctaa atggcagaac aagaataaga gctgctgcaa 2679901 tatttaataa aattgtcggt ataaaccggt caagcacaaa tccgttaaac gtcataatgt 2679961 ctttatgaat caaagactga atgccgaata cgtaaaattc gagcagacag acagccagaa 2680021 ctgctatcaa tatcactaca aatgcgtttg tatgcaacac tttaaacgct tttgaagcca 2680081 aatagcatag ccctgcaaaa ccaaacatgt aaacgcctaa tagacttgta tagttcatgt 2680141 catatagaaa gccaaaaata aatccgtaaa tcatcgcgtg tttttggttg ataaaagccg 2680201 acatgaatat caatacaagc atcaaaaaac gcggggcgag cacttggtca tctgtaacga 2680261 aaggaaaatg caccaaatct gtaaaaatgc tttccgcaga aaaaacaagc atcataacga 2680321 aagggagaag gaaacgtttc acgatccttc ctcctctgta tcgacagtcg gcacgtcacg 2680381 gttaacaacg atcacattat ttaaatctgt aaggtcagcc gcaggtttta cataagcaac 2680441 cttcgttaat ccataggaat ctgactcgat atcagtcact tcaccgattg tcagcccttc 2680501 tgggaaaaca ccgcctgtcc ctgatgtttc aataagatcg ccttttttca cgtcttgttt 2680561 atccttacgc tcaataattg tcatcttaag acgttttttc tctttgtcat atccttcgat 2680621 caagccgtag cctttgctgc ctttttttcc ggaaattttt gtcgcgactc tgttattgcg 2680681 gtcagtatcg cttaaaagct gaacagcaga cgtaaaattg ttaagtccgg agcttttgat 2680741 cttgccgatt aatgcgcctt tttcgtttgt aacggccata tctttcgcta cgttttgctg 2680801 agtccccttg ttaatggtga cctgtttcgc ccaattatca gggcttctgg cgatgaccgt 2680861 tgctaaaatc ggcttgtaat ctttaatcga tttgacatgg ccaagctcgt cacgcaagga 2680921 tttgttttct tcttcaagct cttgaagctt ggcttcatat tgtgtctgtc cgtcaagttt 2680981 ttctcttaga cgctcgtttt ctttgtatgt gttttttaaa tcattgatgt tctcaaatat 2681041 tcctgcaaaa aattcggcag gcgtatgaaa aatattttga aatactcccg tcgtatcgcc 2681101 gatcactttc tcaggccagg tggtattgcg gccgcccttc agcgaaaatc caatcatagc 2681161 caccaatatg ataatacaca gaagtaatag cattaaccgc ttattcggca tcgtgttaca 2681221 cctcttctat tgaactcccg attatctagt tttccctttg aaaagatgga tgtgctccag 2681281 tgctttccct gttccgatcg ctacacaatc aagcggatct tcggcgataa ggaccggcat 2681341 ttttgtttct tcgctgatga ctttgtccaa attgcgcaaa agcgctccgc cgccggttaa 2681401 cactatacct ctgtccatga tatctgctgc aagctcaggc ggtgtttttt cgagtgtgct 2681461 cttcactgct tcgacaattg tagatacagt gtcgcgtaga gcgttagaaa tctcttttcc 2681521 tgtaatttca attgttttcg gcaaacctgt gagcaaatcg cggccgcgga tttccatgtt 2681581 gtcggattct tcaggagctt ctgcagatcc gatttccatt ttaatcgctt cagccgtacg 2681641 gtcaccgatc atcagattgt acgtttttct gatgtagttg ataatcgcgt catccatctc 2681701 atcaccggct acacggattg actgagacgt tacgatgcct ccgagggaaa taatcgcaac 2681761 ttctgtcgta ccgcccccga tatcaacaac catgcttcca gtcggttccc aaactggcag 2681821 attggctccg attgctgcgg caaaaggctc ttcaatcgga tacgcgtcac gcgctcccgc 2681881 ctgtcttgtc gcatcgataa cagcgcgttc ttcaacagct gtaatgcctg atgggacaca 2681941 taccattaca tatggttttc tggcaaacat gcctttattt tttatggcct gattgatgta 2682001 atatttcatc atcgtcgccg ttgtttcata atcagcgata acgccgtctt tcatcgggcg 2682061 aagagccacc acgttgcccg gtgtccgtcc aatcatattt ttcgcatcat ttccgacagc 2682121 gacaatcgat ttcgtatccg tctgcaaagc gacaactgac ggctctctca caacaattcc 2682181 ttttcctttt acaaaaacaa gcgtattcgc agttccaaga tctataccaa ggtctctagc 2682241 accaattcca aacatatgta tgtatcttcc tttcttaaag caaaaatacc ctaaagggaa 2682301 aaactcataa actctattat agcttaattc gacgaaaaaa aaagtgttac aaatatcctt 2682361 tttcctttaa actcacaaat tttttatccc cgatcaccaa atggtcaagc agctcgatgc 2682421 caatcaggtt tccgcattca aacagccgtc ttgtcacttc aatatcttcc ctgctcggcg 2682481 tcggatctcc agaaggatga ttatgaacac agataaagga agcggcagat cgtttaaacg 2682541 cttctttaaa cacctctcgc gggtggacaa tagatgaatt caggcttccg ataaatacgg 2682601 tgcgtttatg gatgacttga ttttttgtat ttaagtataa acagacaaaa tgctcctggg 2682661 ttaaaaagcg catatcctcc atgacaagat tagcgccgtc ttccggggag cgaataacga 2682721 aatgttcttc gttggctaat ttatgaatcc ggcttccaag ctcaactgct gccagtattt 2682781 gaatcgcttt taccataccg attcccggga tgcttgacag ctcttcaacc gatgcttcct 2682841 tgagcaggcg cagcccgtca aatgagcgca gcagccggtt tgacaggtcc aaaacagatt 2682901 cgtgtttagt ccctgtccgc aataatatag ccaaaagttc atgattcgct aagttctcgg 2682961 ctccgacttt caggagccgt tcccttggct tttctttcat tgggaaatct ttgagtttta 2683021 atggcagatc gtgtatgacc aagcactcct tttctttccc ttcccgttta tagaaccgtc 2683081 atgcccttat atcaaaatgg cgaagagctc tcattgtttt tgatatagga aggcccatga 2683141 ctgaataata atctccgtct attttcttta caaaaagcgc gcctcttcct tggatgccgt 2683201 atgcacctgc tttatccatc ggctcttttg tttcaatata tgtccaaatc tcttcttcac 2683261 tgagggacca aaacgcaact tctgtcttat cataaaaagt ctcgctgtga ttttcagctt 2683321 gaatgctgac cgcggttatt actgagtgac ttcggcctga aagcctccgc agcatagaag 2683381 cagcttcttc ttgatcctgc ggtttgccaa gacattcgcc gtcaaggcat accattgtat 2683441 cagcaccgat aacgattgca tgcgggtgga gatcagctac agccttagct ttttgttttg 2683501 ccaaccattg gacgttttct tctggtgaaa agtttcgatt taatttttct tctacttcac 2683561 tgacaataat ggagtagggc agctggagaa gatcgaggag ttctttcctg cgcggagatt 2683621 gtgatgcaag tattagcggt tttgtcatgt tcgtcatcct ttcagggttt gcttaagaaa 2683681 aaaagatact cgtttatcct accaaatcac gaggcttgtc acaatttcag aaaaataact 2683741 ttttcatgac aaaataaaaa aagcctgtca ctaaaggacg aaggctcagg gcactatctc 2683801 ttattttacg acggctaaca gctcctgctg agccttccac ccggcttcag cacttggatc 2683861 ctctaattcc tttaaagcct gcaaaatcgc ttttttctct cctgtttctg acgcttttgt 2683921 ttcaccaagc gacttttcta ttttctctac actcgctttt gtaatgtctt cgtcgagaat 2683981 cgcctttgct gcaagctccg ctgtttcctt aaaagaatct gtcatatctg actctattga 2684041 taaggaaagc tccttgcctc cccaggcttc aaaatcactg tcgattaaaa cctgtcctaa 2684101 ctgctgtgag acctcctttt cacttgctaa gcctgcaata acatacgtat acccgtcatc 2684161 ctttgacagt gacacggcgg aatatccttt ttcggtcaat tgttctgtta acgtttcggc 2684221 gcccttttca tttgaaaatt ttccggcttg cacagcgtat gttttgtatg taccttcagt 2684281 ttgtgccgct tgtttttctg cgcctgaggt ttgtttatca gcagaagtat cccctgcttt 2684341 tgccgtttgg ctgcctaaag aatcctctaa agaggccggt gctgacgctt ctttattccc 2684401 cgatatgttt aacgcgaata accctaatcc agtgccaatg acagccgcga aggcaatcgt 2684461 cgcggccact ctttttaccg gtttggcagc cccggtcttt ccttttgcgt aaagctttgt 2684521 ttttttcttt tgaaaaggag gaacaacttt agggtcctct ttaaacacct tgtcctcctc 2684581 ggaatcccaa ttgaattcat cttcatcagg gtgttcctgg gatgccgcaa cctcttgttc 2684641 tgcctgtctt ttttcctccc aatttgaaaa tgtcatgctt ttattcgcct ctgtctcagg 2684701 cgtctcttgt tcgtaaaccg tctcttcttt tccattaatc gtcaccttga gggctttttc 2684761 tgcggcttta ctgttttttt tattctttct ttttttcaat tccgcttcct cccttcattt 2684821 gcttgaccgt tcttgtcggc ttttcatgct acacacttta gcacaggcaa agaaaaaaag 2684881 aacaagactt ttgtcgcctt gtccaaaaaa cgttcgtcaa atttttcagc agtcagccca 2684941 atgccatttt gatataaaaa gaaatgatag agtcaccgta taaataggct aaaatgctcc 2685001 ctgcggctat agcgggggcg aagggaagcg gctgcctttt agcgagtcta ccagtcagaa 2685061 cagctgccgc tccatataat gcacctatca aaactgaaaa gaaaaaggca gctgccagca 2685121 ttttcacacc aagcacaaag ccaatcaccg caaataattt aatatctcct ccccctactc 2685181 ccccatgggt gattgcggca attacagcca gaaacaaaaa tccggctgcc gcacctaaca 2685241 ggcctgcata ccaggaatca agcggagaaa tcaatctcgc ggccgccaaa aagggaagaa 2685301 agaaaatcaa tattcgattt ggaatcagca taaaatgaat atctgtcact gcaacaataa 2685361 tgagaagaga gataaacacc acagcgggaa acagttccag cgatatgcca aagcgtattc 2685421 ctgcggcggc aaataaacac gctgtcacaa gctctgctgc gggatacata aaagaaatcc 2685481 tatgcccgca gcttttacat ttaccttttt gaaataggaa tgacaggatg ggaattaatt 2685541 ctgcaggagt taatgttcgc cggcaaaacg ggcatgatga acggggcgca ataatagata 2685601 gatgtaaggg gatacggcac ccggccgtat agtaaaaaga accaaggata agcccgaaga 2685661 taaaaagaat ggatagcata gacaacacac ctttactcat tgagttctgg tatggattgt 2685721 agcaaaatgg acatcctgag ctccaattgg gaatattcaa ttttacacat gaaaaaaacg 2685781 gcagaatctt tttttgattc tgccggagcc ggatgctttt atttcaacct ttttcgaatg 2685841 tcagaaataa agtaaagaga tccggtaatc agcacaattt catttgagcc ctttttactt 2685901 tctatgaatt tgattacatc gtctggatct tcactccagc ttttattgct gatttcactt 2685961 gcatcataga gatcttttgc aagggaagca cgcgggaaat caaaagaagc aaaatgaatc 2686021 gcatgagcaa tggtttccag tcttttaatc atgttctgat acggtttgtc ctttaacgcg 2686081 ctaaacacca cagaaatgcg tgaattggcg aaacgctgct tcatcgtttc cgccagcttt 2686141 tcaacacctt cttcgttatg cgcaccgtct aaatataccg gaggatgttc ctgaacaagc 2686201 tctaaccgtc ccggccaagc agccttcaca agcccgctcc ttaacgcttc gtcactgata 2686261 tgggcgatat tctccttatt gagccactcc gcagccaaaa tggacaaagc agcattttgt 2686321 ctttgatggg tgccaatcag agatgtccga atatcttcat agcatttctc ttccgttttg 2686381 aatgaaaact gttctcctgc aggcagagcc tcttcattga aaataacaca tgcatcatgc 2686441 aatgactgga acggcgcagc atgccgttcg gcttcatggc ggatgacctg taaagcttcc 2686501 ggctgggtaa ctgctgtaac gattggaata ccttctttaa taatgccggc cttttctcct 2686561 gcaatttctt caatggtgtt tcccaaaatg ttcatatgat cgtgtccgat gcttgtaatc 2686621 acagttaaga gcggttcaac cacattagta gaatcgaatc taccgcccag acctgtttca 2686681 aaaataacaa aatcgacctt atgaaactct gcaaaatata aaaatgcaca agctgtcata 2686741 atttcaaatt ctgtcggctg tccgtattcc gtttgatcaa gggcttcaac gtgcggtttc 2686801 atttgattga cgagtgctgt ccattcctca tctgaaatcg gtatcccgtt tacgctgatc 2686861 cgttcattaa acgtaataat ataaggcgat gtaaatgttc caaccgtata tccggcttcc 2686921 tgcagcatag aacggataaa agcgacagtt gatcctttac cgtttgttcc tgcgacgtgg 2686981 aacgctcgga tttttttttc aggatgtcct aaccgcgcca tcagctgttt cattcgacca 2687041 agtccgggct tcaccccgaa tttcagcctc ccgtgaatcc agctgcgcgc atcttgatat 2687101 gcagtaaaca atgataatcc cctcttttat aagacaaggc ggtttctcta gaaaccgccc 2687161 cggcttttca ttaacccttc agctcagcca ttcgtttttg aacagcgtca cgcttcgcca 2687221 cataatcttt ttctttttca cgttcttcat caattacgtg tgcaggcgct tttttcataa 2687281 atccttcatt tccaagtttc ttttggacac gctcaacttc ttttgtcagt ttatcaaatt 2687341 ctttttgcag acgggcaatt tcttcatcaa tattgattaa gccttcaagc ggaagaataa 2687401 cctctgctcc tgagacaacg gccgtcatcg ccttatcaac agcctcaata tcggtgccga 2687461 ttttaagcac gctcggattc gtaaagcgtt caacatatga acggttcgct tcgaggcggg 2687521 acgctatttc gtctgtgctt gttttaatgt acagttcaac ctgcttgctc attggcgtat 2687581 tgacttcact gcggatattg cgcacagaac ggatcagctc aacaagaagc ttcatgtcag 2687641 ctgccgcttc agtatcggta tgctccggca ctactgcagg ccattgactt actgtaatcg 2687701 attccccttg gtgaggaagg tgctgccaaa tttcctccgt taagaatggc ataaacggat 2687761 ggagcagacg catcgtttga tcaagtacgt aagcaaggat ggaacgggta gttttcttag 2687821 ccgcttcgtc ttctccataa agcggaagct tcgccatttc aatataccaa tcacagaaat 2687881 catcccaaat aaagttatat aaatggcgtc ctacttcacc aaattcatat cggtcagcaa 2687941 gctgggtcac gtgctcgatc gtttcattta atcgcgttaa aatccacttg tcagcgactg 2688001 acttttcacc tgacagatca agctcatcgt acgtcatgcc atccatattc attaatgcaa 2688061 aacgggaggc gttccaaatt ttattggcaa aattccaggt cgattccact ttttcatagc 2688121 tgaagcgcag atcctggcca ggagagcttc cagtcgcaag gaaataacgc agagaatcgg 2688181 ctccgtactt gtcaatcaca tccatcgggt cgacaccgtt gccaagagat ttactcattt 2688241 tccggccttg ctcgtcacgg attaagccgt ggattaaaac atctttgaac gggcgctcgc 2688301 ctgtaaattc aatgccttgg aaaatcatgc gtgataccca gaagaaaatg atatcgtacc 2688361 ctgtcacgag aacatctgtc ggatagtagc gtttaaagtc ttcagccgtt acatcaggcc 2688421 agcccattgt ggagaaaggc catagcgcag aactgaacca tgtatccagt acgtctgtat 2688481 cctgttccca attttcgctg tcttccggcg cttcaagtcc gacatatagc tcgcctgttt 2688541 ctttatgata ccaggcagga atacgatggc cccaccacaa ttgacgggag atacaccagt 2688601 cgcggatatt ttccatccag tgtaaatacg ttttttcgaa acggtcaggc acaaagttga 2688661 ccttttcttc ttttttttgc agctcaatcg ctgcatcagc aagcggctgc atgcgcacaa 2688721 accattgtgt agaaagataa ggctccacaa cagccccgct tcgttcacta tggccgacag 2688781 agtgcatatg atcctcgatc ttgaagagaa ctcccgcctc ctgtaaatct ttcacgagct 2688841 ttttgcggca ttcaaaacga tccatacctt gatattggag cgcattttca ttcatcgtgc 2688901 catcttcatt catgacaagg atgcgttcta aattgtggcg gttgccaagc tcgaagtcgt 2688961 tcggatcatg agcaggcgta attttcacgg cacctgaacc aaattccata tcaacatagt 2689021 catcaccgac aatcggaatt tcacgattta caatcggcag gatcaccgtt tttccgataa 2689081 ggtgtttata gcgctcgtct tcagggtgaa cggcaacagc tgtatcaccg agcattgttt 2689141 caggacgtgt cgtcgcaatt tcaattgagc ctgaaccgtc agcaagcgga tagctcatat 2689201 gatagaatgc gccttgaaca tccttgtaaa tcacctcaat gtcggatagg gctgtttttg 2689261 tcgctgggtc ccagttaata atatattcgc ctctgtagat caggcctttt tcataaagct 2689321 taacgaatac ttcccttacc gctttgctca agccttcatc cagcgtaaaa cgttcacggg 2689381 aataatctag gccaagacct aatttcgccc actggctgcg aataaagtca gcatattctt 2689441 ccttccactt ccacgtttct tcgaggaatt tttcacggcc taaatcgtag cgggatttgc 2689501 cttcttcacg aagtttcgcc tccactttag cctgtgtcgc gatgccggcg tggtccatgc 2689561 caggaagcca cagcacatca tagccctgca tgcgtttcat tcttgttaca atgtcttgca 2689621 gcgttgtgtc ccatgcgtgg ccaaggtgaa gtctccctgt tacgtttggc ggcgggatga 2689681 caacagagta tggctctttt gtctggtcac tgcccgcttc aaaaaatttg ccttttagcc 2689741 aaaaatcata tcggtctttt tcaaccgctg ccggatcata tttcgtcggc attgtttgtt 2689801 cattcgtttc catcataacc ctccagcatg tttaaaaatg gctgagaacg aaaaaagagc 2689861 tcttcatccc tgtaaaagga cgaaaagctc tttcgcggta ccaccttttt tcatgaactc 2689921 aatcagttca tgcacttata acggataacg ggtgtttccc gaatttctct actcttcttt 2689981 caagaaatta tgctcccggg cgaccttcca atcagacaac ataagaagcc tttcagcaaa 2690041 cggcttctct ctctgcatgc gccttttttg tactcttccc gttctaagca ggtgtattta 2690101 tcagctcatt gtatacatta tttatgttct ttattatagt aaaagtgttt ttgattcgtc 2690161 aatcatcttt tccaaaaaca ccgctttcta tacagatggg caggcaccta ttgcccaagt 2690221 ttacatatga tgcttgtaaa tgcgtagagg aggatgcacc gtgaagaaac gtttcagctc 2690281 ttattcgctg ccgccatggg taaggcaaat tcggcttgta tccgcacaag tgattattcc 2690341 cattacgatt tttcaaggaa tcagaaccat tttctttccg acaacctttg atgttttgct 2690401 gctcgcaatc ctaatctttt tagcttgcgc ccttcattta gaatggatat aaacaaacaa 2690461 gtccgcgcca ttaagacgtg gactcgtttt cagcctgaaa ttttttctct tgttcaatct 2690521 gatgaatttt catcacaaac ggctctatgt ttttcatttg ccaataagcc tttaataatt 2690581 gtgtacattc ctctttttca tgctgtcttt tcccagtttg ataaccgttc agcaccttgt 2690641 acatggctgc cggatatgcc atatagctga gaaaaaggct gacttccgct tcacgcaaag 2690701 ggaatgattt cgtatatcca taaaaccatt cgacgcattc cggacaagct ttcggaaagc 2690761 ctctgaacat ttttgtataa aagccgagca ggtcgttttg cggcggaccg acagatgctc 2690821 tttcgaagtt tgtaaaatat ccggtcccgg catcattata cagaaaatgg tgtatagaca 2690881 ggctgccgtg gttcattaca acccttgaaa cgtccttttc ctttgcggac tcataccagt 2690941 cctccagccg ttccagcgca aagttcaccg cggaaatggt ttcagaaaaa taggttatgg 2691001 cctggagttc aaagggagaa aggtaccatt ccttctccgc tctatccaca aactgctcat 2691061 agaaaatttt atcttgttcc cacttttttt tcgtttgccc gtaataacgt tcaatctcat 2691121 cacgtctaac ctttagttcc tgcgcggttc tctcgtgaag acgggctgtt tctctaaata 2691181 aataagcatg tttttgatcc cgttcttcct cttggtcaaa ttggagccaa ggcattaaat 2691241 agtagatatc tccgtattgt atgcctgctg agaaaaactc accgctattt gttctgtaaa 2691301 cgggaacgaa tgaacgaaag cctttttcct caatcgccac catatgatct gtaaaatgct 2691361 tgccgcgacc ttctttcaat tttttcaggg caaatatgcc gtagtctgta tacactttcc 2691421 aaacaagagg actgacaggc tcaataaatt gagcagtcag tccgtattcc tgaagaaccg 2691481 attgggtatc ttccatttca ttcaccacat tttccgatca cttacggttt acgcatggct 2691541 atttttatat tgaggaatat agagaatctg tcctgctttt aattcatcat ccaaggctaa 2691601 agaattcatc ctgatcagct gctgggatgt aatttcatac cgttcgcata aacgctcgat 2691661 cgtatcttcc tgctgcacaa tacaaatttt cattctcgaa aactcatccg cttcttttgt 2691721 aaagagtttt gttaaataaa gagaattatc actttccttt gtttgaggtt ccttcgtttc 2691781 agcagcagga gcaaccctag gaacagcatc cgtttccttc ctttcagtct cagaagattc 2691841 aggcagctgg aaggattgaa aaggtgtttc ttccttaggc tcttcagctg atggtgtttt 2691901 tctcacttca atttcgaagc tctcttcctc ttgttcttcc tcctccagca gcttaggcgc 2691961 tgaataaaaa gaatcctcct cttcttgttc aggcaggaag gtacggtatg ccggttcagg 2692021 caattcttct tgagatgcct cctccgagct tgttttttga ttgaaatgga aatgtaaatc 2692081 ggcattgtca ttctccatat atacagctga agctgtttct ctgctatctt ctatggagag 2692141 agcggcctct gatacactct ccaaagcttc atccggttcc gcctcttctt ggcaaagcgc 2692201 aggatcagcc tgatccgatt gagctgcttc ttcattttga gcctcttggc gcagcgcata 2692261 ttcatgatta ggagacactg ttgtttcctc tttttccttt gcaatcacag tctctgaatg 2692321 aagctcagct tccaaagcag gcgattcttc tgctccaacg tgttcacgaa gctcagtctc 2692381 cgctggagag tctgcttctt cacgaacatc cgctattgca gctgccggct ctgccgtttc 2692441 tttttttgct ttaacgatct cttgaatctc tatttctgaa ggatcaggtt ctggctcaga 2692501 ttcttctgtt tccgattcag cacgaacctc cgtttccggc acagcaagct cttctgactc 2692561 ttcttcctct ttcacatctt ctctggcctc tggttctgaa gcaaccgatt caggcggctc 2692621 agattctgct ttttctgtct ccagttcttc acggagcccc gctttcgaga taaaaagttc 2692681 tggcggttcg gctggcggtt catgctgaag aactgcttcc tctgccgatg atgcacccgg 2692741 ttcttctact acactatgtg ccggcggctc tgaaagctct tcctccctga atgccgcagg 2692801 agcttcatat aaaggtatct ccggctcttt gtcttgcgta tcgtccaaaa gcccttcgat 2692861 cgctaaatca gcttgaattg ttaaaatgcg cgaatccgtc aattgatagt caaatgcgtc 2692921 aataaagacg aagacatcct gtaaatggct cactttattt ttcggaatgg taatatccac 2692981 aggaaaacag tgagtcagtt ccgcacttcc atcctctctc tttctgactt gttcaacaaa 2693041 ccgcttatct gtataaatct cttcggtatg tttgttttga tctatgttgt actcacctgt 2693101 aagttcaagc gatcctatga ttgatacata atcatttact tcctgaaccc taatatcagg 2693161 atctaatgaa atagaaagca gttcagaaac ttcctgtcct ttttggaaac agatcgattc 2693221 ttctacagaa aattgcaatc gatgattttg cggcaagttc atatcctcct ttcatctaat 2693281 ccttaaaatt agatgtcact aaaggtgtat gtatgaactg gagaaaatat gagtgggaga 2693341 gcacgaaaaa accggcacaa ggagtccttg ataccggttt tcactcttat ctgcggctga 2693401 tctcagcaaa tactttctca gctgcctgga ttgtgttttc aatatcttca tcagtatggg 2693461 ccgttgagag gaaaagacct tcgaattgtg atggcggaag gaatacccct tcatttgcca 2693521 tccctttata atagcttgcg aacagcttca aatcagatga tttcgctgtt tcataattga 2693581 tgactggttc gtttgtaaag aagaaaccga tcatcgaacc tgcacggtta aaggtatgcg 2693641 gaatgccatg agccccggcg gtttttgaaa ttccttcttc cagtctgtcg ccttttttga 2693701 tgaaattctt gtaggattca ggtgtcagct gtttcaatgt ctctaagcca gccgtcatcg 2693761 caagcgggtt gcctgacaat gtaccagctt gatagatcgg accgcttgga gcgatctgct 2693821 ccatgatttc tgcctttccg ccataagcgc cgacaggaag tccgcccccg attacttttc 2693881 ctaaacaagt cagatcaggc gttacgccga agtagccttg agcgcagtta taatcgaccc 2693941 ggaagccagt catcacttca tcaaaaatca gcagggagcc gtactgctca gtgatatcac 2694001 gcagaccctg aaggaaacct tcttgcggcg gaacaacacc catatttccg gcaactggct 2694061 ctacaatgac tcccgcaatg tcttcaccga attgctggaa agcaagcttt acactttcta 2694121 aatcattgta cggaacggtg atggtgtttt tcgcaatgcc ttcaggcacc cccgggctgt 2694181 caggcagacc gagagtggca acacctgaac cagctttaat caagagagaa tcgccgtgtc 2694241 cgtggtagca gccctcaaat tttaaaatct tgttgcggcc cgtatagccc cttgccaaac 2694301 ggagggcact cattgtagcc tctgttccgg agcttaccat tcgtacaatt tctacagatg 2694361 gcacacgatc aatgacgagc ttagccagtt cattttctac ttcagtcgga gcaccaaagc 2694421 ttgtcccgta ttcagccact tttttgaggc tttctacgac gcggtcattt gtatgcccta 2694481 aaattaaagg cccccatgac aagacgtagt caatatattc attcccgtca atatcaaaga 2694541 ttttcgagcc ttttccgcgc tccataaaaa tcgggtccat gtctaccgat ttaaatgcgc 2694601 gaacgggact gttcacaccg cccggcatga gtttttgcgc ttctttaaaa gccgtttttg 2694661 atttttcata gcttctcatc tgcctcaact cctgtcaact gaataaaatt actccgcaag 2694721 ccatttcgct gcgtctttcg catgatacgt aataatcagg tcggcacccg cgcgcttcat 2694781 gcttgtcaaa atttccaaca caatttcttt ttctttgatc cagccgttct gcgctgcagc 2694841 cttcaccatt gaatactctc cgcttacatt ataagcgacg agcggcaaag taaactcatt 2694901 ttttacgtca cgcatgatat ccatataaga aagcgaaggt ttgacaatca aaaagtccgc 2694961 gccttcctca acatctgatt gtgcttcgcg gagtgcctcc atacggttgg cagggtccat 2695021 ctgatatgtt ttgcggtctc cgaattgcgg tgtgctgttt gctgcatcac ggaacggacc 2695081 gtaaaactca cttgaatatt taacagcgta agacatgatg ggaatattga cgaatccttc 2695141 tttatcaagt gcttctctga tcactgtaac aaatccgtcc atcatgtttg atggcgcaat 2695201 gatatccgca cctgctttcg cttggctgac agctgtctgc gccaaaagct ccagcgattc 2695261 atcattgaga atgactccgt ctttgacaag tccgcaatgg ccgtggtctg tatattcgca 2695321 caggcacgtg tcagcgacaa caaccatttc agggaagtgt tctttaattt ctgtgatggc 2695381 tttttggaca attccgtgat catggtacgc ttgtgttccg caatcatctt tttcttccgg 2695441 gatgccgaac acgataacag attgaatgcc cagtttgacc agctccgcta cttcatcctt 2695501 caataaatct aatgatacat ggtgaacatc aggcattgac ggaacagctt ttttgccttc 2695561 cagcccttca acgacaaaaa tcggatatat aaaatctgat ggatgcaaac gtgtttcctt 2695621 taccatttct ctcattgctt ttgatgtccg caggcggcgg tgtctattaa atgattgact 2695681 catattctct cttcctctct tgacatgctg cacattaact caagcatgcc atctattgta 2695741 aatgtatcag gcgtatgcga tgtgatgccg tacgtcagaa gggcatcatt tgttaaaggc 2695801 ccaatgctga tacaggccgt cccattcgcc ttccactttt ttaattcttc tcccaagaca 2695861 tgcataaacg tatgtacggt tgatgaactc gtaaatgtta catagtcaaa ggaatattga 2695921 cccgcagcgt ctttcaatgc ctcaatgcct tcttcatccg gaatcgtttc gtagagaacc 2695981 cattccttta cttcaaaacc gagcgggaca agctcttgtt ttatcacatc acgtgacaaa 2696041 ttccctttca tcacggtaat ggtctccccc ggttcagcat gctgcttaag agcgtcagcc 2696101 aattgttcag caatatactc ctgtggcatc acatcaaccg atacgttatg catttttaaa 2696161 cggcgcgcgg ttttttcacc gacggctgca atttttttat gcgcagggag aataagctga 2696221 ttttccttca gataagaaaa aaagaagtct gccccgttca cacttgtaaa aacaagccag 2696281 cctggcgcgg caagatcctc tcttacctgt tccgcaacat cattcggcaa agcgcggcga 2696341 aacgtaatca aagaggttaa aaccgcttta ccgccaagcg cctccacttt ttgctgaaat 2696401 gatgctgcct gtgccttatt ccgggtgaca agcactgttt ttcctttcaa cggaaaatca 2696461 ttttccatcc tcgtcaagct cccgttttac acgatcaatt aaatcttttg ctcctttgtc 2696521 agccataaga gcggcacagc gctttcctac ttcctccgga tcgtttccgg tgacggtttc 2696581 tttaaaaatg attttgccgt caggtgaagc gacaagacct gtcatttcaa tttcatcctg 2696641 tccatttaac acggagtagc ccgcgatcgg aacctggcag ccgccctcca tcgcgtttaa 2696701 aaaagcacgt tccgctaaga cagtccgttt tgtatattca tctgtaaact gagaaaacaa 2696761 cgccaacagc tcttcatccg attctcggca ctcaatcgcc agggctccct gccccacagc 2696821 aggcaaacag cgctcaggct caaggaattc ggttacgaca tcttgcttcc aacccattct 2696881 ggaaaggccg gcagccgcta aaataattgc gtcataatcc tctgtttcca gcttttgaag 2696941 tcttgtatct atattacctc taatccattt aattgtaagg tcagggcgct caatcaaaag 2697001 ctgcgcgctt cttcttaaac tgcttgtgcc aatgacagca cctttcttca tttctgaaag 2697061 ctttacgcga ttctttgaaa taagggcatc acgcgggtcc tcccgttcag gaatacagcc 2697121 gatcacaagg ccttcaggca aaacagcagg catgtccttc atgctgtgca ctgccatatc 2697181 aatctcttcg tttaaaagcg cctgttcaat ttctttgaca aaaagccctt ttccacccac 2697241 ttttgagagt gtaacatcga caatccggtc gccctttgtc acgatctctt taatttcaaa 2697301 agcaaacgaa ggattgattt ccttcagttt ttgaataacc cattttgttt gagtcatagc 2697361 gagtttgctc cgtctggaac ctactttaat cgttctcatc atttctttcc tcccgaatct 2697421 gcttgggaca tcgtttaact gaaccaatgg aattgcgaca ggcttccaag caggaaataa 2697481 ttgatcatca gcaccagaaa acaagccgta ttccacagtg cagcgacctt tccttgcagc 2697541 tccttaatca gcctgatata aagataatag ctgtacagca gcaggacgac aaacgaacca 2697601 agcactttgg cgtcaaacca atacagcgtt tctagtgaga catacgccca aatgacgccg 2697661 agaatcaaac tcagcagcag catcggaacc ccaatgacat ttaaaacata cgccatataa 2697721 tcaagcttag ataaatcttc tattctcaac agccattttc cccacttttt ctttttcagc 2697781 agatgatatt gaaacatata tagcacagaa aaaacgaaag aaagggaaaa agcgccgtat 2697841 gaaagaatcg ccattgtaat atgaatcacc aaaagctcgg atacaagctg cccggaaaaa 2697901 gcagctgact gctgctctgt cggtgaaaat gtgtgaatgg cgatcataga aaatcctata 2697961 acatttgtaa aaaacacgat aaagtcaaca cgtaaaagct ttgtcagtac aagtgacagc 2698021 gtgacaagca cccaggcata aaaataaagt gcctctgtca catttaatac cggaaaccgc 2698081 cccgtcaccc acataaaata ggccaaatac acggtttgca gagtccagac aatagaaagc 2698141 aaccagaagg ccatttttcc agccttccgg ttgtgttgaa gaaaatctat aaaataaaag 2698201 agtacactta acgcgtaaat gacgattgtc ccctcattaa gtcttgccat tgcagtatca 2698261 atcattcagc tttcactcac ttacaagtgg gctaaagccc gcttttgatt cagccttctt 2698321 aaaagagtgg accttctggc tgctttcaac ggttttcatc atttgacggc ccgcagcttc 2698381 ttcaatatca aaaatctgca taaacaacgc gagcttttct tcagaatcag catctgccgc 2698441 aagctctttc acctttaaaa tcggatcacg aagcatttgg ttaataatac ttttggtgtg 2698501 tttgttcaac agttttttct ctcttgtgct taagtgaggc agcttacgct caatgctgtc 2698561 catcgtttct gactggatgg caagcgcctt ttcgcgcaat gcagaaataa caggcacaac 2698621 accaagtgta ttcatccatt gtttaaattc cacaatggtt tcttcaatta acagttcaac 2698681 tttttcagct gtttctctcc gctctttcat gttcgcttct acaatgcctt ccagatcgtc 2698741 gatatcataa agaaaaacac cttcaagatc attcagcgcc ggatcaagat ctctaggcac 2698801 ggcaatgtcg accataaaca gcggacgtcc cttgcgaagc ttattcgcgt tttccatcat 2698861 ctctttggac acgacaaatt cacttgcacc ggttgaactg attaaaatat cagcctccgc 2698921 aagcgcgctt tcaagctgat tcaagcttct cgcttcacct gaaaaacggt ctgcaagctc 2698981 cttcgctttc aagtatgttc ggttaatgac agtgaccttg ccgattccct gtccgtgcag 2699041 gttttccgca gcaagctcgc ccatttttcc cgcaccgaga atcaatatgt gcttgcttga 2699101 aagatttccg aagatttttt tggcaagttc aactgcagca tagcttactg acaccgcatt 2699161 tgagccaatg tctgtttcgg cgtgagtccg tttgcccact gtaactgcct gcttaaacag 2699221 ctcattaaaa atagtcccga tcgttttttc ttgctgagct gttttaaagc tgtcgcgtac 2699281 ctgtccgaga atctgcgttt cgccaatcac catagaatca agtccgcagg ctacacggaa 2699341 taaatgctca acagcggcat cgctctcata aaacgttaag aacggtgaca gctcttcttt 2699401 gcttaattga aaccaatcag ctaaaaactt ttttatataa taacggccgg tatgaagctg 2699461 gtcgactacc gcataaattt cagtgcggtt gcaggttgag acaatgatgt tttcaagaat 2699521 gcttttctct tctttcagct gcaccattgc ttctgccagc tcattcggct gaaaacttac 2699581 tttttcacgt atctcaatag gggcggattt ataatctact cccacaacaa gtatatgcat 2699641 cgctctaatt acacccccaa cacccaatct taatttataa tcattctaac atagaactca 2699701 ttatttataa taattataac atagtttctt tcacaaaatg tgaacagatt ttaaaattct 2699761 tatgctatat tagaaaaagc ttcagggaaa agaagcattc ctattgacaa taccaaaaac 2699821 agcagaaatt tactacacat cagctctaaa aaacaagaag gtgatatgca tgaaacaaaa 2699881 atcaatttta ttcccttgtc tgctgcttgc cgcttctgta tatgcatggc tagaaagcgg 2699941 ccaagccgaa ctgttttcag ggcaggatca atggcctgtt ctcctcatgc tgttaggcgc 2700001 agcctttgta tatcaaggaa aaaaagaagc cgtcacaccc cattttttta tcggtttgct 2700061 tctcttcggg atcggtttac acttttttgc caagccgaaa tgggtatggt ggccggatga 2700121 ttttgaaatg ctcctcttta tgatcggctt ctcacttctc gtttcaaccg ttcaaaaaaa 2700181 agaatatgta tatgaagctg tgtcgatgat ttgtttttcc ctgtttttgt actttttcaa 2700241 acaaattatg gcatggcttg agtctgcgca tattccaaca gcgcttctga aggagtattg 2700301 gccgtttgtc tttattggaa tcagtttatt gttattattg ataaaacgaa aaaaatctat 2700361 acgataaata aaaccggtag aggatcctct accggtttat catttttttg atcgctcccc 2700421 aagcttcgtc ttttcccttt ttcgtttctg aagaaaagag gatcagctcg tcttccggat 2700481 caatatttaa tgtttgtcgg acaaccttcg cgtgtttgtc ccatttacct ttcgggatct 2700541 tatccgcctt tgtagcgata acaataacag gaatgccgta atactttaaa aattcataca 2700601 tctgtacatc atcattagat ggcgcatgcc gcaaatcaac gatctgcacc acagctttta 2700661 attcctcgcg tgtcgtgata taggtttcaa tcattctgcc ccatgcttca cgctcagact 2700721 ttgacacttt ggcaaaaccg tagcccggca catccacaaa atgcagctca tcattgataa 2700781 tgtagaaatt aagcgtttgt gtttttcccg gctttgatga cgttctcgca agatttttgc 2700841 gattgattaa tgaattgata aaagacgatt ttcctacgtt cgatcttccg gccaatgcga 2700901 tttccggaag ccccccttca gggtactgtt ccggttttac tgcactgatc acgatttctg 2700961 actttgtgac tttcatttct tctctcctac taaggcatgt tccaaaacct cgtctaagtg 2701021 ggacgccaat ataaatgtca gcccctccct gacgctttcc ggaatatcct ctatatcttt 2701081 ttcattatct ttaggcgcaa taatggtcgt taatcccgct ctatgtgcgc caagcgcttt 2701141 ttcctttaag ccgccgatcg gcagcacgcg cccgcgaagc gtgatttccc cagtcatgcc 2701201 gacttcacgc gaaaccgccc gtcccgttaa agcagaaaca agcgctgttg ccatcgtaat 2701261 accggctgac ggaccatctt ttggcaccgc accctctggt acatgtatat gaatatcata 2701321 cttctcatga aagtcaggtt caatgccaag ttcttctgtt ttggatcgca catagctgaa 2701381 tgcagcctga gcagactctc tcataacatc tccgagcttt cctgtcagga ttaatttccc 2701441 ttttcccggt gaaagcgata cttcaatcga aagcgtatct ccgccaacgg ttgtatacgc 2701501 aagccctgtc actacaccaa cttgatcctc tgtttcagct tgtccatatc tgaaaatgcg 2701561 ttttccgata aaatcttgaa ggttcttctc agtaaccgta attcgttttc gctcttcagc 2701621 aacaatggct tttgcagctt tacggcaaat tgcggcaagc tggcgttcaa ggcttcttac 2701681 acccgcttct ctcgtatagt aacgaataat atcaagaatc gcctgatcac gcagctgaag 2701741 attgcttttc ttcagcccgt gttctttgat ttgctttgga agcaagtgat cctttacaat 2701801 ttcaagtttt tctatttctg tgtagcctgc gatattaata atttccattc tgtctctgag 2701861 cgggcccggg attgtggcca aattgttcgc cgttgcgata aacagcactt tggataaatc 2701921 aaaggtttct tcaatatagt gatcactgaa gctgctgttt tgctctggat caagcacttc 2701981 aagcatagcg gatgatgggt ctcctctaaa atcagatgac attttgtcaa tttcgtctaa 2702041 taagaagacc ggattcagct tgcccgcttt tttcatccct tgaataatac gtccaggcat 2702101 tgctccgaca taggtccgtc tgtgtccgcg tatctctgat tcatcccgaa ctcctccgag 2702161 tgagattctg acgaatttgc gtcccaagct ttttgcaatt gatttggcta aagacgtttt 2702221 tccgacacct ggaggtcctg ccaaacagag aatcgggcct ttcagggatt ttgtcagctt 2702281 ctggacagcc aaatattcta aaatacgttc ttttactttt tcaagcccgt ggtgctcttc 2702341 gtccaagaga cgtcctgctt ctttcaaatc aagcttatca tctgtttcat ccgtccacgg 2702401 aagagcaacc agccagtcga tatagttgcg gatcacagag ctttccgcag aacttgacgg 2702461 aattttttca tatctgttca attctttaag cgctgtttct ttcacatgat caggcatgcc 2702521 tgcttcttcg attttttccg tcagcgtctg aacttcgcca gttttgcctt ctttatcgcc 2702581 aagctctttt tggatcgcct tcatttgttc acgcaagtag tattccttct gcgtacgctc 2702641 catcgaacgt ttgacgcgct ggccgatttt tttctcaatc tccagcactt ctttttcatt 2702701 attaataaaa tcaatgacct tgttcagcct gtctttgaca tcagccgttt ctaaaatatc 2702761 ctgcttatcc tttagtttaa ggggcagatg agaagcaacg atgtctgcca ttctccccgg 2702821 ctcttcgata tcagtaaccg cagcgtacgt ttcggccgag atttttttag aaatttttat 2702881 gtactgatca aagtggtcta gcaaagtccg catcaatgct tcgtcttctg tatcttttga 2702941 atcatcttca tgaataagtt gaatgtcaac cgacgtgtaa tcctcgtgtt cattgtattt 2703001 gacgatatgg gcgcgcttga ggccctccac caacacacga atcgtaccgt tcggaagctt 2703061 cagcatttgc ttaatttttg tataggtgcc gacagtgaaa atctcgtctt caccaggttc 2703121 gtctatcgaa atatcctgct gagtggctaa aaatatcata tgatcatgca tcattgcctg 2703181 ttcaagagcc tgaaccgact tgtcacgtcc tacatctaaa tgcaaaacca tcgtcgggta 2703241 cactaataaa cctcttaaag ggaggagcgg gatgctgcgt tttaattctt ctgccatgtg 2703301 actgacacct ccgtgacttt agtatgaacc attataatac aactttttca tccttgtaca 2703361 ataaacggca tggttccatt ttctataaaa cagtctcctc gtagtatacc ctttctttct 2703421 gatatgaaaa aggaaaagat gtccttcatg aaaaaaaccc tattatcaaa atagggttta 2703481 aacggattct ttattgattt cgatatgaaa cggtttttgt tccgttggcg gattcaccaa 2703541 aatttcatca agcacttctt ggaacgtctt cactgcaata atctcgatcc cgtcaatctg 2703601 ctttaagatg gcctgctgat tttcatatgg gataatcacc tttttcgcac cggactgctt 2703661 ggccgctttt attttcggaa tgacgcctcc gatgggtttc acaagaccgt tcaggctgat 2703721 ttcgcccgtc atcgcaacgg tattgtcaat aggaattttg tgtatcgccg agaaaatccc 2703781 cgccgccatc gcaatgcctg ctgacggccc atcaatcgga atccctcctg ggaaattgat 2703841 gtgaatatca taatcagaag gcttcattcc cattgtccgg agcacggtta atacattttc 2703901 aaccgaaccc ttcgccatgc tttttcgcct gatcgatttt gattggctgc cgatgctttc 2703961 ttcttcagct attcctgtga tgttaattga tcctttatct tgagccgcgg ttacacttac 2704021 ttcgatttcc agaagcgatc cgctgttagg cccatagact gcaagcccat ttacaatgcc 2704081 aacctgtggt tcaacaccga ttttttgctc gtgctttgga gtaagctgac tggagtgaat 2704141 gacccattca atatcctcaa tcgtaatgtc ctttcgattc tccgttacag ccatccccgc 2704201 tgcgatttga atcatattga cggcttcccg cccgttccgc gtgtagctgg tcaaaagatc 2704261 cagtccttct tcggagatat ttttttcaat tttatccgct gctgttttgg caaccgtttt 2704321 cagctcgtcc ttttcaagct cgcggaaaaa aacctccaaa cagcgggacc ggatagctgg 2704381 cggaatttcg tttggcattc tcgtggtcgc gccaatcaag cgaaaatcag ccggcagccc 2704441 attttgaaaa atatcatgaa tatgattcgg aatttgtgta ttttcctcac tgtaatacgc 2704501 actgtctaaa aagacttttc tgtcctcaag caccttcagc attttattca tttgaatagg 2704561 atgcagctcc cctatttcat caataaacag cacaccgcca tgggcatggg tgacagctcc 2704621 ctgcttcggc tgcggaatcc cagcctgtcc catcgctccg gccccttggt atatcgggtc 2704681 atggacagag ccgatgagcg gatcggcaat tcctctttca tcaaaacggg ctgttgtcgc 2704741 atcgagttcc acaaagacag cctgctcttt aaacggtgat tgtttatgtt tttttgcttc 2704801 ttccaacaca agccgcgcag cagccgtttt cccaactccc ggtggcccat agacaatcac 2704861 atgctgagga tttggcccgc ataaagccgc ctttaatgct ttaatgccgt cttcctgtcc 2704921 gacgatatct ttaaagcttt tggggcggac cttctcagat aatggctcgg acaagctgat 2704981 agcgcgcatt ttccgaagct gctccatttc cttctttgat tctttatcta tcgtgacctt 2705041 ttgtgtcctt tgatttttaa gcaaattcca aaaatacaaa ccgatgatga tcccaaaaaa 2705101 cagctgaata aataacgcga tccctgtcca actcatggtg gtccctcctg aaaaacaatt 2705161 tatgtatcca attcattcct ctgattgcta gtatctccca tagaagacgg gaataaacgt 2705221 ttttccggaa gagttgcatg caaaaaaacc tcctgagtgt taccactcag gaggtttgtg 2705281 cttatcttta tgcagatgtt ttatcttggc ttacctcagt gccgtctttt aataagaggc 2705341 gaggaggctc tccgtgtgtc acagttgccc cggtgattac acatttttca atgtcatcac 2705401 gagaaggcag ctcaaacatc acatcaagca tgatgccttc aatgatagaa cggagtccgc 2705461 gtgctccagt cttgcgttca attgcttttt tagcaatttc agaaagcgct tcttcttcaa 2705521 actcaagctc aacgttgtca agctcaagca ttttcttgaa ttgcttaaca agagcgtttt 2705581 tcggttttgt taagatcgca accaatgctt cttcgtcaag cttttcaagg cttgcaataa 2705641 ccggaagacg tccgataaat tcaggaatta acccgaaacg gagcaaatct tctggaagca 2705701 cttttgaaag aagatcttct ttctcaagat cagcagcttt attgtcggca ccgaatccaa 2705761 tcactttttg gcctaaacgg cgtttgatga tttgttcgat accatcgaaa gctccgccgc 2705821 aaatgaacaa aatatttgtt gtgtcaattt gaatgaattc ttgatgagga tgcttacgtc 2705881 caccttgagg cggtacgctt gccactgtac cctcaagaat tttaagcaat gcctgctgta 2705941 caccctcacc tgacacatca cgtgtgatag acgggttttc agattttcta gccactttat 2706001 cgatttcatc aatatagata atgccttttt cggctttttc cacatcataa tcagcagctt 2706061 ggatgagctt caagagaata ttctctacat cttcacccac gtatccagct tcagtcaaag 2706121 atgtagcgtc cgcaatcgca aacggcacat ttaaaatgcg agccaatgtt tgcgccagaa 2706181 gggttttacc gcttcccgta gggccgatta atgaaatatt actttttgaa agctcaacat 2706241 catcaacttt gctgttggag ttaatgcgct tatagtggtt atacacagca acagcaagtg 2706301 atttcttcgc ttgatcttgg ccgatgacat attcattcaa aatttcgcga atttcctgag 2706361 gctttggtac gtctttaaat tctacttctt cttctgttcc gagttcttcc tctacaattt 2706421 cagtgcagag ttcgatacat tcgtcacata tatatacacc aggtccagct acaagcttac 2706481 gaacctgatc ttgtgttttt ccacagaacg agcattttaa ttgtcctttt tcctcgttaa 2706541 atttaaacat tctttcaccc cttaatcttg tctcactttt tcttttaccg gcagagcaaa 2706601 agaaaatgat tcttgaaacg aacgagtatg tattgcattt taccatactt tccaaaaaga 2706661 cggtaacaat gtgtttctga cttgcacatt ctatatgtat gacaaaaaac agccctgcat 2706721 taactatatt gccccaagaa aaagagataa ctcataattg tacaaaacaa ggcacgaatg 2706781 attcgcgccc tgttttatta gtactattat tatgcaccat attaacggtt ttctacaaga 2706841 aaatcaattg ctttgcgaac ttttaaatct tctttcatcg cgtcagtaga accgatggct 2706901 tgtttaatat tttcaacagg catgttgtat gcttcagcca tttttgtaag ctcagcatca 2706961 acttcctcat ctgatacttc aaggttttcc gctttcgcaa tcgcctcaag agtcaggtta 2707021 gattttacgc gtttttcagc atcttctttc atttgctctt taagcgcagc ttcatcttgg 2707081 cctgagaatt gagtgtaaag ctcaaggttc atgccttgca tttgcagacg ctgttcgaat 2707141 tctttcagca tgcggtcaag ctcagtgtcg accattgctt gaggcacatc gatttcagca 2707201 ttttcagaag ctttcagaac aagctcttca cgcaatttag cgtcagcttc gttttctttt 2707261 gcttcttcta aacgtttctt tgttttttca gttaattcag caagtgtttc cacttcttca 2707321 tcgatatctt ttgcgaattc atcgtcaagc tcaggaagct ctttcgcttt gatttcgtga 2707381 attttcactt taaacacagc tggtttgcct gcaagatctt cagcgtggta ctcctcaggg 2707441 aatgtcactt caacatcctt ctcagcacct gcttcaaggc caactaattg atcttcgaag 2707501 ccagggatga atgaaccaga acctacttct agagagtagt tttcagcttt tccgccttcg 2707561 aaagcttcgc cgtcaacgaa tccttcgaaa tcaagaacaa ctgtgtttcc ttcttcaacg 2707621 gcgccttctt cttttacaac aagctcagct tgacgctctt gaagggcttt tagttcgttt 2707681 tgaacatctt cgtcagttac agttgtgtcg tctttttcaa tgcccaggcc tttgtattcg 2707741 ccaagcttca cttcaggttt tactgttact ttcgcagtga agattaagct ttcgcctttt 2707801 tcgatttttt caacatcgat ttcaggacgg tctacaggct cgattccagc ttcttcaacc 2707861 gctttagggt attctacagg aagaagaata tccaaagcat cttggtaaag agcttctacg 2707921 ccaaagcgct gttcgaataa tccgcgagga attttacctt tacggaatcc aggaattgaa 2707981 acttgtttta ctactttttt aaatgcatca tcaagtgctg ttttaaacgt ttcagcatca 2708041 acttcaaccg ttaaaacgcc ttcgttgcct tcttgttttt cccattttac agacatgtgt 2708101 ttccctccaa aaatctattc aggttgtgtc ggtcttccat tctaaagcaa tcattcggct 2708161 tcgtccaaca aaaacaaagc tgccaaagat cagaatcatt atgtatagat gttaataatg 2708221 aactgcaaag cctgtccaac cgtatttctt ataacccgtt atacacaaat acaaccacta 2708281 tattataaca taacacatag cgctttcaac tatatggcgc gatttacaaa taagaaattt 2708341 cttcaatatc ttttaacatt gtgcaagctt catcgagttc tctgtctgta aattcataca 2708401 tcatatgaag ttcttcgctt tcaatttcaa tcccgtgcat ctcgtaaccg actttatgaa 2708461 gggcagccgc ccaaaggtca gccgacagca atttcggctg gaacggatat aaaacgtaca 2708521 aatgtcttct ccacaattct tctactgctg catataaggt tggattttca tttccaagtg 2708581 tctcatctag caccctgaga acacggtgaa gaatcggcgc ggcatcaggc ggaacaatct 2708641 ctgacggttc aattgtcaac gactcgccaa atttactaat gtgtacaggt ttactgtact 2708701 catgctcagc caacagcatg acaatcatcg ttttgataat cggatgggct gaggggtctt 2708761 ggaggattgt tttgagcaat cctgtatact ttgctacgtt acggtctttt aaggaatgaa 2708821 tgagattcat ttgctcctca gggcttgcca gcactttctc ggtgtcaatt gtatcctcat 2708881 attcttcggc ccaagcctcg tcctcacgat ccggatcggt cattttccgg ctgaaatcca 2708941 gcagcttata aaattgctcg gcactttctg ccggcagctg attttcttcc aaaacggctt 2709001 caatggtgct tttgacttct tcgtactttt tgagctgaat taagatggtc atgtacacct 2709061 gcaaaaccgt aaaataatgg ccataacctt ctttgagcat cttctcgcac acgctttctg 2709121 cctcttccag ctcgcccagc tctaaaaagc agatggccat ccctaagtga agatcggatt 2709181 cagtatcatc atatttcatc gcttctgaaa acagttcaag cgcttcttga tacttttttt 2709241 ccttgagtga tgacatccct ttttccacaa ggcggtcttt cagatgagga aaaggaataa 2709301 tttttgcgtt tttcttgtca tgcgtcatac ctatattcct ttcaggcatt tattttgttc 2709361 aagtgtatca acacctgtga acaaaaacaa gaaatgaaag gtttcaccag gcaaaaaaag 2709421 ccgccggaca aataccggcc gctttttcag gcttgaagcc aagagcttct ttgtgattca 2709481 aattgcttga tttcatcttc cagcagcagc gttaatgaaa tttcatcata tccgttgatc 2709541 agcatctctt tccaatgcgg atcaacttca aatgaaattt gattgccttc actgtcatga 2709601 atcagctgat tttcaaggtc aacagtcatt tgcaatgact ggttttcata ctggccgaca 2709661 agctgtttcc aattgtcata tggcatgcgg atcggaagca tgccgttttt aaagcagttc 2709721 tgatggaaaa tatcagcgaa tgacggcgca atgataattt taaacccata atcatcaagt 2709781 gcccacggag cgtgttcacg cgatgacccg cagccgaagt tttctcctgc tattaaaatg 2709841 gaagctcctt gataaacagg ctggtttaat tcaaattcag ggttcggttc accattcgca 2709901 tcatatctcc agtcaaagaa tgcaaaacgt ccgtagcctg ttctttcaat cctcttcaaa 2709961 aattgcttag gaataatctg gtctgtatcc acattgatcc gatttaatac ggctgctttc 2710021 cccgtatgtg atttcaaagg ttccatctcg cgcactcctt acacaactgt tttttcctga 2710081 taaaactttc tgacatcaac gaagtgtccg tgaatggcag ccatcgcagc cattgccggg 2710141 ctgacgagat gtgttcttgc accttttcct tgtctgccct cgaagttgcg gttagaggtt 2710201 gatgcacagc gctctccctc aggaacaaca tcattattca tactcaaaca catgctgcag 2710261 cctgactctc tccattcaaa tccagcttcc aagaaaatct ggtcaagccc ttctttttca 2710321 gcctgaagct tcacgctttg ggatccgggc acgacgatgg cccttacgct gtcagctacc 2710381 ttcttccctt tgatcatgtc agcagcctgt cgaaggtcag tcatgcggga atttgtgcag 2710441 gaaccgataa atacgtgctc cactttaatg tcttcaattt tttggtgagg agtcaatccc 2710501 atatattcat aagcacgaat cgcttctttt ttatcgtctt ctgcagaaaa gctttccggc 2710561 gcaggaactt cagaatcgac aggaagaacc attcccgggt taatgcccca tgtcaccata 2710621 ggggaaattt tgttgccgtc aaggacgata gatttatcgt aaacagcgcc cgggtctgtg 2710681 cgcagcgcct tccattcctc tacggccttg tcaaattctt cgccttttgg cgtgtacttg 2710741 cgatttttgc aatattcaaa cgtcacctcg tcaggtgcaa tcaaacctgc tcttgctcct 2710801 gcttcaattg acatgttaca aacagtcatt cgttcatcca tcgtcatatt tctgaatact 2710861 tccccagtgt attcaatgac gtagcctgtg ccgaatttca caccgtattt gccgatgaca 2710921 gcaaggatga catcctttgc cgttacccct ttttgaagcg ttccatctac gcgcacttca 2710981 agtgtttttg gacgctgctg ccaaagtgtc tgtgtggaaa ggacatgttc aacttcactc 2711041 gtcccgattc caaatgcaag agcgccgaaa gcgccatgtg ttgatgtatg actgtcaccg 2711101 cacacaatcg ttttccctgg aagcgttaag cctagttcag gtccgacgac atggacaatc 2711161 ccttgatcca cactgtgaag atcggcaagg cgcacgccaa attcctcaca gtttctttca 2711221 agcgccgtta cctggcgttt cgcaacttca tcctttatct caaaacgatt gacagtcggg 2711281 atgttgtggt ccattgtcgc aaatgtgttt tggggtcttc tgacctttct tcccttttgt 2711341 ctcaagcctt caaatgcctg aggagacgtc acctcatgaa tgaggtgcaa atcaatatag 2711401 agaagatccg gctttccctc accatgtttt acaatatgct gatcccaaat cttttcgatg 2711461 attgttcgag gcatcatctt ttatttcctc cctctaccta gagctaagac cgcttaacgt 2711521 aagctgtcac acattagaaa ttgtattttc actcatgatt gctgccttaa cttcctctgt 2711581 aatggcctga gtgctgctga actcttcact ccgtgccaag tctcttgttc tttttccaga 2711641 agccaagact ttgtttaccg catcttctac agctttcgct tcctcttcaa gcccgaaaga 2711701 tgttctcaaa agcattgccg ctgacaatat ggctgcgaac ggatttgcca tccctttacc 2711761 ggcaatatca ggcgcggagc catgaacagg ttcaaacaga tgaaggccag agcttgatag 2711821 gctggctgac gggagcattc cgagcgagcc tgtaagcatg gacgcttcat cgcttaaaat 2711881 atcaccgaac atattttcag tcaccacgac atcaaattga ttcggtgcat aaattagctg 2711941 catggccgcg ttatccacaa gcatgtgctc aagcttcaca tcaggaaatt cttgtgcaac 2712001 gtcctcagcc acttcacgcc acagccggct tgattcaaga acattcgctt tatctacaga 2712061 ggtcactttg ccttttctgg ctgccgccat tttgaagccc tctctgatca ctcgttcaat 2712121 ttccgttcgc ttataaaaca gtgtatctac tgcttcctgc tcaccttcag tgtttacata 2712181 acgtttgctc ggctggccga aatacaagcc gcctgtgagc tcacgaacga taacgaaatc 2712241 aacattatct atatattctt ttttcaaagg cgaagcgtca gaaaggcttt caaatacctt 2712301 cacaggccgc aaattcgcaa acaaatcaag ctgttttctg atgctgagca gccctttttc 2712361 cggtctcagt tccgaaggat tttgatccca tttcggtccg ccgacagcac caagcaatat 2712421 cgcgtctgca tttttacaag cagcaacggt ttcctccggg agggggttat gatgttcatc 2712481 aatagccgcc cctccaatca ggccatattc aaattcaaat tcatggttaa agcgttcggc 2712541 aacacttttc agtacgtctg tcgctgattc taatacttca gggccgatcc cgtctccggg 2712601 caatagagca atacgtttct tcaagttaac cgttctcctt tcttttatga tccgacagct 2712661 gtgtggtttt tcaatccgct catattcgac tggaaaacca attgacggtt tactgcgttc 2712721 aaataggctt tcgctgatgc ttctaatacg tcttgcgcta tgccccgccc tgctgattct 2712781 tttccgttca ccaaaactct tacatacacc tgggcaaatg catcttcgcc ttttctatta 2712841 gactgaatgc ggtagtctaa gagctccaca tccttatcga tgcagcgctc aagcgtattg 2712901 tagattgctt ccacgcttcc agctccagtt gcagcttcct gaataagctg tgcgttttct 2712961 tgatttttca aagatagagt agccgtaggg acctgacttg ttccgtaatg tacttgcaga 2713021 gaaagaaatt catacccaat cttgcgatct gttacttttt cttctaaaat aagagaaaca 2713081 agatcctcat cagtgatttc ttttttcttc tcagtcaact ctttgaacat cgtaaagaat 2713141 ttattaatct cttcactgtc aaattggaat cctaaagcag tcagccggtc tttaaatgcg 2713201 tggcgtccgg aatgtttacc taggacaagc gcatctgcgg ttacgccgac aagctccggt 2713261 gaaataattt cataagtcga tttttccttt aaaaagccgt cctgatggat gcctgattca 2713321 tgagcaaatg cattatctcc aacaaccgct ttgttgcgcg ggacagccat gcctgtcagt 2713381 ttgcttacta aatcacttgt tctcttaatc tcgttcagcg taatacctgt ttcgacttgg 2713441 tagaaatctt ttctggtatg gagggctacg gcaatttcct ctaatgccgc gtttccggct 2713501 ctttcaccga tcccgttcac agcgcattcg atttgatcag cgccattttc aatcgcagca 2713561 agagagtttg cgactgccat tcccaaatca tcatgacagt gggctgaaag ctttgctttg 2713621 tgaatgttcg gaacgttttc tttcatatat ttaaagatat ttccgtattc cgccggggcc 2713681 aggtagccga cagtgtccgg aagattgata acactggcgc ctgcgtcaat cactttctcg 2713741 acgatttctg ctagaaacgg cagttcagtg cggcaggcat cttcagctga ccattgcaca 2713801 atcggaaaac gttcttttgc gtatttcacc attccaactg ctctttcaat gacttgttca 2713861 cgtgtcattt tcagcttgtg cttcaaatga atgtccgatg tcgcgataaa tacatgaatt 2713921 cttggttgag cgccatcctt taacgcttcc caagcagcat caatatcacc ttttacacaa 2713981 cgggccagac cagttactga acaattttta atggttcttg cgatttcctg aacagctaaa 2714041 aagtcacctc gggacgaagc gggaaatccc gcttcaatga tgtctgcccc gagtctttcg 2714101 agctgcttag ctatggcaag tttctcctgt gtattcaagt tcactccagg ggactgttca 2714161 ccatcacgaa gcgtcgtatc gaaaaaatta attttgcgca acggagacca ccgcttcctt 2714221 cttcttgcct tgtttcacaa acggcatcat ttcacgaagc tttcttccca ctacttcgat 2714281 ttgatgttcg ttctcgcttg cattgatagc gttgaaacga ggacggttta cttggttttc 2714341 gacgatccac tcttttgcga atgtaccgtt ttggatatct tttaatactt ctttcataga 2714401 ttcttttact ttggcgtcca caacgcgagg gcctgatacg aaatctcccc actgtgctgt 2714461 gtcagagatt gaatatctca ttcctgcaag tccttcttcg tacataaggt ctacgattaa 2714521 tttcagctca tgaagacact cgaagtatgc aagttcaggc tgataacctg cttcagttaa 2714581 ggtttcaaat ccggctttga caagcgcgct taatccgccg caaagaactg cttgctcacc 2714641 gaacaaatct gtttctgttt cttctttaaa tgtcgtttct aatacgcccg ctcttgcgcc 2714701 gccgattcct ttagcataag cgagggcttt gtctcttgct tctccagtca catcttgata 2714761 gattgcgaac aatgcaggta cgccagctcc ttgctcatat gttcttctta ccaagtgtcc 2714821 cgggccttta ggggccacta agaatacatc tacatccgcc ggaggaacaa tttgatggaa 2714881 atgcacgtta aatccatgag cgaatactaa tgattttcct gctgtcaatt catctttgat 2714941 ttcagcttcg tatacttttt gctgctgctc atccggaagc agaaccatga tgatttcggc 2715001 ttgggctgcc gcttctttta ctgaaaatac tttatgtccg tcttcttggg cttgagtgaa 2715061 agattttcct tgtctaacac cgacgatcac gtctactccg ctttctttaa ggttcagggc 2715121 atgtgcgtgg ccttgcgaac cgtacccgat aaccgctact gtttttccag ccaatacgtt 2715181 ctctttgata tcaccgttat aatatacttt taccatttca atctctccct tgttatgttt 2715241 tatacaatag atattgtttt attggatgac gccttttgct gggttcccct cgcaaaagcc 2715301 gttgtacctg ttctcgcgat ttctttaatg ccataaggtt ttaataactc aataagcgct 2715361 tcaattttgt tagattcacc tgtcacctga acaacgatgc tgtctctgct gacatcaacg 2715421 acagaggctc taaacggttc tatgattcca ttaatctctg ttcttgttga aggtgcggag 2715481 acaaccttga ttaaggccag ctccctctgg acaatcgatt gatttgtgat gtctgtgact 2715541 ttcagcacat caatctgttt gttgagctgt ttcgttaact gttcaacatc attttcacct 2715601 tcaacatgaa cgacgaaggt gattctggaa acgccggctg tttctgtgtg tccaactgta 2715661 atgctttcaa tgttgtaatg cctttttgtg aatagaccgg tgatccggtt taacaccccg 2715721 gagcggttca ccacagtcaa tgtgataatt cttttcaagg tttcaccccc accatttcat 2715781 gcagcccttt ccccggagcc accatcggga atactttttc ttcgctggca acccgcacgt 2715841 caatgacaac aggttctctt gatgttaatg cctcttccag cttttccttt gcttccgctt 2715901 ctgatgaaat tctgatgcct ttaatgccgt atgcttcgga caatttgacg aagtcaggct 2715961 gagaagcgaa tttagattct gaataacgtt cttcatagaa aatttcctgc cactgtctga 2716021 ccattccgag acaagcgtta tttaaaatca ctaccttgac cggaagattt aattcgcgaa 2716081 taacatcgag ttcttgaagc gtcatttgga atccgccgtc tccgacaacc gcgacaacag 2716141 tagcatcttt ttcggccagc tgtgcgccga tcgccgccgg aagaccgaat cccatcgttc 2716201 caagtccgcc tgacgtgacc catttatctg ctttttggaa cggataaaat tgcgctgacc 2716261 acatttgatg ctggcctaca tccgttgcga caatggcctc tccttttgta aattgatgaa 2716321 tatattcaat caatttctga ggtttaaaac cttcttcttc attatctaca taccagagcg 2716381 gatactcttc tttccattct gcgagctgtt ttttccattc gcttgaatcg ctttgtttgc 2716441 cgtcttgttt gatcagctcc tgcaggacaa ttttgctgtc tccgactaca ggaatctgtg 2716501 ttttcatgat ttttccgatt tcagctggat caatatcgat gtgggctatc tttgcgtttc 2716561 tggcaaagtg tttcaggttt cctgtgacac ggtcatcaaa acgggcgccg atactgatta 2716621 atagatcaca ttcatgaagg gccatattgg ctgtataagt accgtgcatt cccgccatcc 2716681 ctaggaaaag cggatggtca gccgggaagc ctccgagccc caaaagggtg tgtgccacag 2716741 ggatttgctg ctgttcagca taatttttta attcttctga cgcttttccg tgcagtacgc 2716801 ccgcacccgc caggatcacc ggttttttcg cactgctcac ggcttccaca agcttgcgga 2716861 tctgcaaata attcggctct gttgtcggct ggtatcccgg gagattcatc tcatgatcgt 2716921 agctgaattc tccttcaatt gttgctacat ctttcggaat atcaatcaat acaggtccgg 2716981 gtcttccagt tgttgcaata tggaacgctt ctttaatgat gcgcggcaga tcttccggct 2717041 ggcgaacctg gtagctgtgt tttgttactg gcatcgtaat ccctaaaatg tctgcttcct 2717101 gaaatgcatc gctcccgatt acagaggttg ctacctgccc tgtaaagacg actaacggca 2717161 atgaatcaat catggcatca gcaaggcctg taacaaggtt tgtcgctccc ggccctgacg 2717221 tggcaatgac gacacccggt tttccggaga cccttgcgta tccctccgct gcatgaattg 2717281 ctccttgttc gtgacgggga aggatatgta ccaaccctga attgtatagc ttatcgtaaa 2717341 tcggaagcac agccccgccc ggataaccga agatcatttc tactttctct ttttttaatg 2717401 attcaatcag cattaatgct ccgctcatcg tctgtgtaca ttcggcagat gctgaatcca 2717461 cctgtacatt agtccccatt ttagttcctc cttttggatt ttcatccttt aaagatcatc 2717521 ttttcattag ctagatagct gattattcaa taaaaaaagc ccttccgccc acaatcagcc 2717581 gcgcagtaac tgcgatagct aaaaggggcg aaaaggcttt tctttccgcg gtaccaccct 2717641 tgtttacggc ctgttaatcg gccgtctcat ggatatttct atccgcttta gtaacgagtg 2717701 aatcaagttc acccggccaa gtcctactgt catttcagac tggcactctg aggcgagttc 2717761 accttgtaaa gcttcgccgg ttctcagcta acccggttct ctgtggaaaa ctttatcaag 2717821 gctacttatc ctcatctgcg cttttcatat tcagccttcg gaacggcttt ccagctgttc 2717881 aagaaggtcg tttgtttttc atttttttag aatcatactg cgatgatttt cgcttgtgaa 2717941 gcttgcattt atcttttgtt gaactcatat tacgccgctt tggacgcagt gtcaacagca 2718001 ttttttaaaa ttattagaca attttgatta atcaatctat attgtatacg ctttcattat 2718061 tggtacaaaa ggaattgcaa atgttaaaag tttttataat ttttttatta atctatcaag 2718121 aatacaccag aattatttaa ttttatataa acatggaaga ttttataaca cgatatggtt 2718181 cgtatatgga ttgagtctga cagatcatct tgcaatccat ttcaatttcg gataggcact 2718241 tctcttgttc cctcggcata cattaatgat atcttgcaaa gaaaaggtga tacgatgaat 2718301 aaatcatttg cagacatgca aggatttcct gcgggctttc caagcttccc caactttccg 2718361 cagcagtact atcctgctgt ccctcccttt taccagcaaa gccagcagcc atttggaggc 2718421 tacggatacg gacagccgtt cagtcaggca tacagcccgt taaccactcc ctctggaatg 2718481 tactcctcat tcccatacgc ttcaggattt tacggacagc aattttcagg tgcaggcttt 2718541 agcggccatg gcggcagctt aagtgctcca gcgatacatg ccggcggatt cagcggggcg 2718601 ccaggcgtac acggaggctt tagatattaa agaataccac aagggccgaa catctattgc 2718661 ggtcctttta ttgttttaaa acgacttcac aagtacagtc acattttctg tctttatatt 2718721 tggaaacagg atggaatatg attaagatga attgaacgat attctgcaca atccgtaagt 2718781 tttcgaggag gaataaaatt gcatataaaa atagacgatt taactggacg tcaggtggtt 2718841 tcactggtga atgagcattt acatagcatg acgcttatgt ccccgccaga aagcattcat 2718901 gccttaggtc tagaaaaact aagagggcct gaaataacat tttggagcgc atgggaaggt 2718961 gatgaactag ctggctgcgg agcgctaaaa gaactggaca cccggcatgg agaaatcaaa 2719021 tcaatgcgaa catctgcatc acatttaaga aaaggcgttg ccaaacaagt tctccagcac 2719081 atcattgaag aagccgagaa gcgaggctat gagcggttaa gcttagaaac gggttcaatg 2719141 gcttcatttg agccggcaag aaaattgtat gaaagcttcg gtttccagta ttgtgaaccg 2719201 tttgcagact acggtgaaga tccaaacagt gtgtttatga cgaagaaatt gtgagacggc 2719261 tttataagga tagataagtg caggggaagg tctgtcttat ctatcttttt ttatattcac 2719321 acatttttca cctttatgat acacgccaat gttttcaatt ttgtttaatt caaagaacag 2719381 cgggaattac aaacgacatg aacgatatca tgcaaattca taaaggagga gattgatatg 2719441 aaaagcatag ttggtgtata tgaaactccg caggaaacca tcgcagcgat tgaaggctta 2719501 cttacaaaag gctatgattc tgatgacatt tctgttgtga caagccggcg agatacagat 2719561 tatttggagt cacgtacagg aacagaagtc aatcaagcta tcgatgcaca tcaggacgaa 2719621 tctgaatctt ttttcgataa actgaaagat tatttcacaa tggatgatac tgctacacac 2719681 agcaaagcat tatccgactt ggatattaaa actgatgaaa tagacaagta tcaagaagat 2719741 ttggatgacg gaaaacttct ggtagccgtc gatacagatg cagatgtaat tgctcctatt 2719801 gataacggca atgccctttc aggcggcttt tcaagcacaa atgaattgga ttatacaacg 2719861 aaagaagaaa aaacgatgcc gctccgggaa gaacagctga aggtcgataa ggaagacgtt 2719921 caaaccggcg aagtagaaat aggaaaagaa gtgaaaacag aaaaaagaga tatggacatt 2719981 ccggtgagac atgatgaaat ttatgtcgaa cgccgtccag tggatgaaaa taaaacggac 2720041 gctgctcccg tcaacgattc ggaagagatc agagttccaa tcgttgagga aaagctggaa 2720101 gtgactaaaa aaccggttgt cactgatgaa gtggttgtcg gcaaacgcac tgttgaagaa 2720161 aatgaacata tttctgaaac tgtgaaaaaa gaagaacctc gtctgaataa agaaggaaaa 2720221 gttgacggct tggatgatga tccgttaaat aacaaatgaa aatcatagac cgacaacaaa 2720281 aaacctcaaa tcctaaatgg atttgaggtt tttcttttgg tacgtcccag gagagattcg 2720341 aactcccgac cgacggctta gaaggccgtt gctctatcca gctgagctac tgggacacgt 2720401 tttgtttttt tgtttttcgc tttaactatc agcgacaaga tttattatat atgggatgca 2720461 ataataagtc aacggttttt tagaattttt ttcatgagga agaaaatttt cttcctcatg 2720521 acattttcat agtgtgactc gattttgcag atcctcaatt tcattgcctg cttggtcgta 2720581 aaaacggact gtcgcagcat cattttctaa tgtcagtata gcatagcttt ctgtcctgcg 2720641 caccctcgga agccggatgc tgcctgggtt aatcatcagt tttccgcgca gcacttcgct 2720701 tcccgcgatg tgcgaatgcc cgaagcagat aacatccgcc ccgagctcct ctgcacgata 2720761 gtatacgttt aacaaggtct gttttatacc gtgaaggtgg ccgtgtgtga ctagtatttt 2720821 tcttgagccg gcagtcagaa gaagctcgtc cttaaaatcg ccggcaaaat cgcaattgcc 2720881 ttttacaacc gcataaggct ccaatgcagg atgcctcgtc tcaagctcag agtccccgca 2720941 atgaatcatg agatcaactt ctgcctcatg ccgtttcgca atggtttgga gttcttcttc 2721001 aagcccatgg ctgtcactga taatcagcac gttcatgtac aagcttcctc cttatgcctc 2721061 caaaagctta gacagctttt taagcgcgtc agccctatgg ctgattttat ttttttcatc 2721121 acttgtcagt tcagccatcg tcttatcttt atctttcacg ataaaaattg ggtcatagcc 2721181 aaagccatat tctcctctcg gttcttcagc aatataccct tcaacatggc cttcgactgt 2721241 ttttgtttcc tctccgggaa tactcacggc cagtgcgcag cggaaacggg cggtgcgctg 2721301 ttctttttcg atacctttca gctcgctgag cactttttcg atatttgcct ggtcgtcttt 2721361 ctgttcccct gcatagcggg ctgaataaac cccgggtctg ccgccaagat tatcgatgga 2721421 tagtccggag tcatccgcaa tcaccatttt gttcactgct ttggcaacag cttccgcttt 2721481 cataatggca ttttcttcaa atgtatggcc tgtttcttca atttcctctg tgaatccaat 2721541 ttcagctaaa gatttgacat catagcctct tggctcaaga atttctttga attccttcac 2721601 ttttcccgga ttatgtgttg caataattgc ttctttcatg atgatcaagc ctttctgtct 2721661 ttatttcagt tctggcagag aatcacccag cacttctttt tgcttgtcaa tcagctcttg 2721721 gattcctttt tccgcaagac ccagaagacc gttcagatcc tctctagaaa aagttgcctc 2721781 ttccccggtt ccctgcaatt ccacaaaacg gccgctgcct gtcatgatga cattcatgtc 2721841 aacttcagca gaggaatctt cttcataatt taaatctaac aaaattccct gttccttatc 2721901 aattccaaca gagattgcag caagaaaatc agtgatcgga tttgtcttga ttgttcctgc 2721961 tttgatcagc ttgccaatcg caatcgccat agcaagaaat gcgcctgtaa tggaagctgt 2722021 tctagttcct ccatcagctt gaatgacatc acagtcaatc caaatcgtcc gttcaccgag 2722081 cttttccaga tctacaacag ctcgaagcgc gcggccgatc aggcgttgga tctccattgt 2722141 tctgccggaa attttcccct tagaagattc tctgattgtt ctttggtttg ttgcccgcgg 2722201 cagcatgctg tactctgctg taatccagcc tttccctccg ccccgcaaaa acggcggtac 2722261 gcggtcctca acagacgcgt tgcagattac ctttgtattt cccgctgtta ttagaacaga 2722321 accttccgga tggctgataa aatccaaatc gaatgtgatt ggacgcagct catcgtgttg 2722381 tcttccgtca tgtctcatgt tttacctccg attgtatgta cataaaccat ttttgtcccg 2722441 gaattgaata aagaaagagg cagccggaac gctaacctct ttcttcctag tatatcaaaa 2722501 atcccaattt aaaaactacc cgtattcact tgagatggtc tggagaccgg ttctgtgagc 2722561 ttttcgcctt tttcatttac cagctctgat tttccgttca ctttaacaga gacgcttttt 2722621 acatccggct gctccgttaa cgtcagcaca atgctgttca gcacttctga agaaatcatt 2722681 ttcgtcttct catcggcgct gccgaatata gattgattga aatccaacgt cacgcgcccg 2722741 tctttgattt tcggtttgct gaccagcttt acatcttcac tgaagtctgt taacagcccg 2722801 ctcaccttgc tcggcccttt agccaattca ttaatggctg ctgtgatgtc gtctttttcc 2722861 gaattgtcga ttcgtttggt caccggcacg tagtattcac tgtcttcatt ttccgccaaa 2722921 tagtagactg tcagcggatg ggtagcagtg agatcattta caccggctgt ttccaaatta 2722981 atgccgtctt tgcggcttaa atcatctgag atcggcgtcc ctcctacagg catctccttc 2723041 agttcatgcc cgtttattct cagcttcact ttatctatcg aactaaattg cgtcagcgtc 2723101 cacgtcacag attgaacgat tttctgttcg tcttctttct tataattttt gaactcatta 2723161 gagaaatcag ctatcgccgt tccatctttt ttgatgtcaa cgttaacggt ggtgtcagcc 2723221 ggcaatacag ctctgaagcc attcggaaga atttcagaca caggcccgcc ctgtacgagg 2723281 tattcaagcg cctgcttagc cgtgctctca cttttaggaa gaggcagcgt ttgcgcaaca 2723341 acatacccgt ttttatcaat gagataaagc tccctcataa cagtagatga ggcttgatcc 2723401 gcttttgcgg tatcgctttt ttcactttct gtttttttgg ctgctgttgt atttgaattg 2723461 gcacccgctt catcgttcac gaatgtaacg tcttgaggcg gatcaatttc ctcggctgcc 2723521 ttatcagatt gaaacaaacc gcatccggat aaaagcaagg cagaggtgag acaagtggca 2723581 ccaatgactg caggtccttt tttcagcata cttttccctc ctaaggatgt ttgtactatt 2723641 atgtatacga gcctctttag gaaatagacc gaagaattcc ggcaaaacag aaaaaaaccc 2723701 gcaacatacc gttgcgggga aaactatctt ttaatcggtt cttgcagtga gatacattcc 2723761 acatgcccga cttcatggcc aaaccaatcg tctgcgattt ttgcaaactg atcacgcgcc 2723821 cctgttgtca ggaactgatg atccggggca atcggagact ggttcagcag ccctttataa 2723881 gagagaattg tgctgacttc ccgggctgtt tcatcgccgg acgaaataat gtttacgtgc 2723941 tctcccatat atctttgaat ggcttctttt aaaatagggt aatgggtgca gcctaaaatc 2724001 agcgaatcaa ttgatgtgtc ttttaacgga tacagcgagg ttttaacaat ctcgtctgct 2724061 gttttgtcga gaaacttccc gctttccaca aaaggcacaa gcagcgggca ggcaaggttt 2724121 tcaaccttca aatcagggtt taatgccaaa agcgcttctt cgtatgcatt gctcttaatc 2724181 gtattctctg tgccgatgac accgatatgc tgattatccg tcacttttat cgctgctctc 2724241 gcaccaggct ggatgactcc gaccaccggt ataccgacgc tgcgctggat gtcatccaaa 2724301 gcgatcgctg ttgctgtatt acaggcgatc acgagcattt tgatgtggtg gttttcgagt 2724361 aaataattcg tcagctccca cgtatattga agcacctctt cttcagggcg cggcccgtaa 2724421 ggacaccgtt tcgtatcccc gacgtagata atattttctt taggtagctg tctcatgatt 2724481 tccttcgcaa cggttaaacc gccaaccccg gaatcaatga ctcctattgg ttgttccaac 2724541 aaaatcgcct cattttctct tcatttcatg ctgcagtttc atcaaagatt tttcgaagat 2724601 ggctatttct tcatctgtaa acgattcgaa catatcacgc agatattcct gtctttttgt 2724661 aatgacctct tggataatcc gttctccttc aggcagcaga tgtatcctga caacacgtct 2724721 gtccgccggg tccttgaccc gctcaacaag ctcatttttt tgcatgcggt cgattaagtc 2724781 cgttgtcgtg ctgcatgcca gatacatttt gcccgataat tcaccgattg tcatatctcc 2724841 taattcataa agccattgca agccgacaaa ttgcggcggc gtaatcgcat attggttaag 2724901 gatttctcgt cctttttgct taatgatcgc ggcaatgtgg cggagtgact tttcaatatc 2724961 cgcaacatgc tccaaaggtt ttgatgtcat ttgtccatcc ctcactcaag gatctcttac 2725021 gcacaaaagc gttccgtgtc tattttcctt cttttttgaa gaaaatgcaa gactcgcagg 2725081 agagaaatag aggactttag tcaaacaaca tcaagaaata aaatttaatt tatgacttgc 2725141 ctacgttttg cacagcattc caaatatggt ttcgaatgtt ccaaacaaac agcaataacc 2725201 ggctccttcc aaaagaagga ataccggcaa ggattaaagc tctagctcac ccattctaag 2725261 aagctcaaca acggcttgcg aacgcccttt cacacccaat ttctgcatgg catttgaaat 2725321 atggtttcga acggttttct cactgataaa tagctcgctt gcaatctcct ttgttgtctt 2725381 atcttgaacg agcaattcga acacttctct ttctcttttc gttagcagcg gcttcgattg 2725441 aaattctttc tccttcaagt attgtaaccc tccttgctaa ggtgagagcg aatcagaaac 2725501 gaatgggttt tgatatagtc gagatatcat atgtaagaag ggcgcaggag gtgacgttta 2725561 caagataatt agtttatcgt gtatgaagaa gcgtttcttt ctcctcatcc gtccagctga 2725621 cagccttgcc gctttccttt gagacttgaa ccatcacgac tgccccggtg aagcagggtt 2725681 cgccttcgag gttctctccg agatagtgca aggtaagaga tgaactgccg actgcgcttg 2725741 ttttcacata gatgcgcaac tcttcataag gcatgacttg gcgcaaataa tcgcattgct 2725801 ggcttgccac gactgtcatg gtctgtttgt tttcactcat catattcagc tttttaaaat 2725861 aagaaatccg cacctcctca aaatatataa aaggggttac attattcata tgcccaaaca 2725921 tgtctgtctc ggaaaatctt acggatacct tattgaaaaa agaaaaggat gttttccatt 2725981 cttgaaacgg catatcaata taagcgggaa gcttcatctt ttttcatctc cttattgttt 2726041 aaaaaaacct ctcccatgcg gaagaggttt tttcttctta tactctgtcg cttccgaaga 2726101 aattgcggaa cgcttgtaag tttgtatctc tattcaaggc tgcaatcgaa gtggtaagcg 2726161 gaatcccctt cggacaggat tgaacacagt tttgcgagtt gccgcaatct gcaaggccgc 2726221 cttcatccat taatgcttct aatcgttcag atttattcat ggcgcctgtc ggatgcgcgt 2726281 taaacaggcg gacttgcgac atcggtgcag gccccatgaa cttcgatttg ctgttcacat 2726341 tcgggcaagc ttcgaggcag acgccgcatg tcatgcattt tgataattca tatgcccatt 2726401 gacgacgttt ttccggcatt ctcggccccg gtcctaaatc gtacgtaccg tcaatcggta 2726461 tccacgcttt tacttttttc aatgaatcaa acattctgct gcgatcaacc tgcaaatcac 2726521 gaacgactgg gaatgttttc attggtttta aacggattgg ctgttcaagc tggtcaataa 2726581 gcgccgtaca agactggcgg ggttttccgt ttataaccat tgaacatgcg ccgcatactt 2726641 cctcaagaca gttcatatcc catgtgacag gggttgtctt ctcacctttg acattaaccg 2726701 gattccggcg gatttccatc agagcggaaa tgacgttcag attcgggcgg tatggaatct 2726761 caaattcttc atcataaggc gtgctgtcag ctgtatcttg acgtgtgata ataaatcgta 2726821 tggttttttg ttcactcatg attatttcgc caccttcttc ttcgagtaat cccgtttccg 2726881 aggcgttatc agtgatacat cgacatcctg atactcaaat tccggcgctt catacgggct 2726941 tacatgttta gccattgttg ttttgagcca ttcatcatca ttacgttcag gataatccgg 2727001 tttataatgg gcgccccggc tttcattacg gttgtatgcg ccaagggtaa tcaccctcgc 2727061 aagctgaagc atgttcgaga actggcgtgt gaacatcgct ccctggttgc tccattttgt 2727121 cgtgtcattg atgttgatct ttttgaagcg ctccattaac tcctgaattt tgtcatccgt 2727181 tttcaaaagc ttgtcattat ggcggacaac cgttacgttc gccgtcatcc actcaccgag 2727241 ctctttgtga agaacatagg cattttcggt tccgtccata ctcataatat cagcccattt 2727301 ttcttcttct ttcttaacgt gagcgtcgaa taaagatgaa gacatgtctt ccgctgaaga 2727361 ttctaagccg tttacatatt tcaccgcatt cggaccggcc accatgcctc cgtaaatcgc 2727421 agacagcagg gagttcgctc ccaagcggtt gccgccgtgc atagaataat cacattcccc 2727481 agccgcaaac agtccaggga tatttgtcat ttgatcgtaa tccacccata aaccgcccat 2727541 agaataatgg accgccggga agattttcat tggaagctta cgcgggtcgt ctcccatgaa 2727601 tttctcataa atctcaatga tgccgccaag cttaatatca agctctttcg gatctttatg 2727661 agacagatcg agatatacca tgttttcacc gttaataccg agcttctggt tcacacacac 2727721 atcaaatatt tcgcgtgtcg caatatcacg cggcaccagg tttccgtatg ccggatattt 2727781 ttcctccagg aaataccatg gtttgccgtc tttatatgtc cacacgcgcc cgccttcacc 2727841 acgcgctgat tcactcatca gtcttagttt gtcatcgccc ggtatggctg tcgggtggat 2727901 ttgaatgaat tctccgtttg cataatacgc tccctgctga taaacgattg acgcagcaga 2727961 tcctgtatta atcatggagt tcgttgattt tccaaagatg attcccggtc cgcccgtcgc 2728021 cataatgaca gcgtctgaac ggaaggattc aatttgcatg tttgtcaggt tttgtgcaac 2728081 aattccgcgg caggttctgt catcatctaa aacagcgcca aggaattccc agccttcgta 2728141 ttttgtgacc agacccgcaa cttcgtatct gcgcacttgc tcgtccagtg cgtaaagcag 2728201 ctgctgtccc gtcgtcgcac cagcataagc agttctgtgg tgctgtgtac ccccgaatcg 2728261 gcggaaatca agcaggcctt caggcgtccg gttaaacatg acgcccatcc ggtctaataa 2728321 gtggatgatc gaaggcgccg cttcacacat cgccttgacc ggcggctggt tggcaagaaa 2728381 gtctcccccg tataccgtgt catcaaaatg ttcccacgga gagtcacctt ccccttttgt 2728441 attgaccgct ccgtttatgc cgccttgcgc acaaactgaa tgagaacgtt tgacaggaac 2728501 gatggaaaac aatttaaccg ccattcctga ttccgctgct ttaattgtcg ccatgaggcc 2728561 ggcaagaccc ccgccgacta cgataatgct tgattgactc atgatagccc ctctccctct 2728621 agtaatctag tactcttaaa caaatgcaaa aatcgctttt aagcctacgt atgacagtgc 2728681 aacaaaaata atcagcgtaa cgtatgtcga aattctttga gaacgaggcg ttaccgtgat 2728741 gccccatgta acagcgaaag accataaacc gttcgagaag tggaaaattg ttgataaaac 2728801 accgacaatg taaaaaccaa gcatagccgg agagctcaaa atattcgcca tcatgtcgaa 2728861 attgacctca gcacccattt gtgcggcaat gcgggtttcc cacacgtgcc agctgacgaa 2728921 aatgagggtg atgataccgg ttacacgctg caggacgaat agccagtttc tcatgtagct 2728981 gtattgaccg gcgttatttt tcgcagtaaa cgctatgtac acaccataaa ctgcatgata 2729041 aattaatggt aagaagataa taaaaatttc caaggcatac ctgaaaggca ggctatccat 2729101 aaaatgagca gcgctattga atgcttcagc gccccttgcg gcaaactggt tgacgactaa 2729161 atgctgaata agaaagatgc cgaccggtat gacgccaagc aaggaatgca atcttcgaaa 2729221 ataaaactct ctgttcccag acattacttt accccctgtt tgataagtgc gaaatgtgct 2729281 aaatctcttc ccccacttct ttcaattgta agcactttat taagatttat tgacaatttc 2729341 attttactcc tccctcaaaa gggcgtcaag aaaacgcgta cataaattat aattttccga 2729401 attgattagt tgattgaaaa attttatttt atcaatatat atttcttgct taatttttca 2729461 taagaattac aggatcattc tgtaatcctc ccccctgttt gagctataat atacgcagga 2729521 gagaggggag acagatatga agtctaaatt tgaagcatct attgacaacc taaaagaaat 2729581 tgaaatgaac gcttatgcct acgaactaat acgagagatc gttctcccag atatgcttgg 2729641 ccaagattac tcttccatga tgtattgggc aggaaaacat ctcgcccgta agtttcctct 2729701 tgaatcatgg gaggaatttc cggccttctt tgaagaagcg ggctggggaa ccctcaccaa 2729761 cgtaagcgct aaaaaacagg agcttgaatt tgaacttgaa gggccgatca tttccaaccg 2729821 gcttaagcat cagaaagaac cttgctttca gctggaggct ggttttatcg ctgaacaaat 2729881 tcaattgatg aatgatcaga ttgccgaatc atatgaacaa gtgaaaaaga gagccgataa 2729941 agtggttctg actgtgaaat gggatatgaa agacccagtg taatcaaaaa ggcggtgact 2730001 gcatagtccc gcctttttga ttgtcattac acagctgaag ggtgttttga aagctcaaat 2730061 gcatcgtgaa gcgactcgac tgctttcacc atgtcatttt cgcttacgac tgttgacact 2730121 ttgatttcag atgtgctgac cattttgatt aaaatgtttt tttgcgccag tacagcaaac 2730181 atttcagccg ctacaccggg atttgagacc atgccggatc caacaataga tactttagcc 2730241 aatttgcttt ctgtctcgat tttctcaaat tccagcgcgt ctttatactc ttcaagcacc 2730301 gcaacggttt ggtctgcatc ttctgttttg acagagaagg aaattccagt cttgtcctcg 2730361 gcctgcgttt ggataatgat atccacgttt atgtttcttt tggcaagtgt tgtaaaaata 2730421 gtagacaaag ttgtcaggcc gctagtcagc ccgtaaatgg ttactcttgt gatttgatct 2730481 tcaaatgcaa tgcctctgac aattaaattc tgttccatgg atgattcctc ctcaattaat 2730541 gttcccgctt cggtttctgt acttgaacgc acttctaacg gcacttggta atttttcgcg 2730601 aactcaactg ctctcggatg aagaacaccg gcgcctaaat tggcaagctc aagcatttca 2730661 tcgtatgaga tgccctcaag ttttctcgct gatttcacat agcgcggatc ggttgtaaac 2730721 acgcctggca cgtctgtgta tatgtcacat ttatcagctt ttaaagcggc agccaaagca 2730781 actgctgttg tatctgaacc gccccggccc aatgtcgtaa tttcacaatc ctctgtcatg 2730841 ccttggaatc ctgcaacaat gacaattttt cctttttcaa gctggtctgc taaaaccgaa 2730901 gtgtcgatat ctgtaattct ggcgtttccg tgaatggcct ccgtacggat tcccgcctgc 2730961 cagccagtat aagacacagc gtcatagcct ttttcctgca atgccattga aaggagtgaa 2731021 atcgtgacct gctcgcctgt cgccagcagc atatccattt cgcgtttgct cggctggtca 2731081 gaaatagctt ttgcaaggct gaccaattcg tcagtggatt ttcccattgc tgaaacgacg 2731141 acaacgactt gatggccttt ctgtttttct gcaattgcgc ggtttgccgc attttgaatt 2731201 ttttcgactg agccgacgga agtgcctccg aatttttgta caataagacc catgtattac 2731261 caccctttac attttggttc gtgcgggtga ggagaaagag cgctttgtcc acaataaaaa 2731321 aagcaatgag aggaatactc tcattgctta tcaattaatc atcataaatg attatgaaca 2731381 acgagatagc cctccaagaa aatgatttct tgacagcctt acatttattc aatgcacggc 2731441 cagcaaataa taccgatggg gttttatttg cttcggcgac gctccccttt cagccttttt 2731501 cacagaatcc atctttctcc aaaggcatac tcttgaagtt cgcacctcta tcttcaccat 2731561 ataacacgat ctaactatga aattagttca cattttatca gatcttattt aaaaggacaa 2731621 cattattttt gcaatttgtc gtaaaggagc tgagccgccg ctgcgggaac accggctttt 2731681 ttgatgtcct caaggcttgc ttccttcatt tttttaacgg aaccgaaatg ctttaacagc 2731741 attttctttc ttttctctcc gatacccggg atgtcgtcca aaacggattg aaacgcgctt 2731801 tttccccgga tttgcctgtg aaaactgatt gcaaaacggt gcacctcgtc ctgaatgcgc 2731861 tgcaggaggt aaaattcctg gctgtttcgt tccagatacg ccacctccag cggatcaccg 2731921 atcagtaaat ttgaggttct gtgtttttca tctttcgcta aaccggcgat cgggatatcc 2731981 aagccgagtt cattttcaat gacatccctt gctgcgttga tctgcccttt tcctccgtca 2732041 atgataatca gatcgggcag cggcagattc tcacgaagca ctctcgtata gcgtcttctg 2732101 acaacctctc tcatagaacc gtaatcatcc ggccctgtaa cagttttgat tttatatttg 2732161 cggtattcct ttttgtatgg tttgccatcg ataaacacaa tcatcgcgga aaccgggttt 2732221 gtcccctgta tatttgagtt atcaaacgct tcaattctgt gcggcgtata aatatttaat 2732281 gcctcaccta gtttctgcac tgccccgatt gaacgctcct cgtcccgttc gattaaagag 2732341 aatttttctt tcaatgcgat tttcgcattt ttatgggcaa gcatgagcag ttcttttttc 2732401 gggccttttt tcggctggtg aacgtttgtt tccagtagct gctcgatcat agattgatct 2732461 atgctgtccg gaactaaaat ctccttcgga aggaagtggt tgttttttga atagaactgc 2732521 ccgatgaacg tgaggaactc ttcatctgct tcctgataaa gcgggaacat gctgacatcg 2732581 cgttcaatga gctttccttg gcggatgaaa aagacctgca cgcacatcca gcccttatcg 2732641 tacgcgtacg cgaacacatc acggtcgact agatcgttca tcgtcatttt ttgtttttcc 2732701 atcgttgatt caatatgggc aatttggtca cgaagctctt ttgctcgttc aaactcaaga 2732761 ttctcagcag cttcatgcat tttctcttca agctcttttt tgacctcatt atagccgccc 2732821 cttaagaaac gtgtaatgct ttcaaccagc tctctgttcg tctcttcgga aatatccttt 2732881 acacacggag caaggcattg gcccagatga tagtaaaggc acactctgtc cgggagcttg 2732941 gagcattttc tgagaggata cagacggtcg agcagttttt ttgtttccct tgctgcctgt 2733001 acattcggat acggcccgaa atagcgccct ttgtcttttt tgacattgcg ggtgacaatc 2733061 agccttgggt ggcgttcatg ggtgagtttt atgaaaggat aggttttgtc gtctttgagc 2733121 atgacgttgt atttcggatc atgctttttg atcagattca tttctaaaat aagcgcttca 2733181 agattggagg acgtcacaat atattcaaaa tcctcgattt ccgtcacaag cctttgggtt 2733241 ttcgcgtcgt gagaaccggt gaagtaggag cgcactctgt ttttcagcac ttttgctttc 2733301 cctacgtaga tcacagtctg ctgccggtcc ttcatgagat aacaacccgg ttgatcagga 2733361 aggagggcga gtttttcttt cagttgtttg ttcatatgtt acccttcctt atgtttaatc 2733421 ctttatttcc agtttaacac gaacgtttgt ttttctctat ggttcacaat tggcgaataa 2733481 aaaaagcgat ccctcaatcg gaatcgctct ggcatgtaag cagcggaaaa ttaaagatgt 2733541 ttgtttacaa gctcttgaag cgcttctttt ggtttgaagc cgactgaagt ttcaactact 2733601 tcgccgtctt ttaacacaag aagagtcggg atgctcataa cgccgtattt tccggcagtt 2733661 tcttggtttt cgtctacatc gatttttacg attttcagtt tgtctcccat ttcttgatcc 2733721 aattcttcaa gaacaggtgc aatcatttta caaggtccgc accaaggagc ccagaagtct 2733781 gccagtacga cgccttcgct tgtttcagct gagaaagatt gatcagttgc ttttacgata 2733841 gccattattg aattcctcca atgtgaaatg atgattttta gtatagcatc tcccattcgt 2733901 tcacgctatt ttaatgctta caaattattt tttcctgatc acagccggtt tactcatttt 2733961 tatatggttg aatgggatat gctctttttt taaaacacaa atctgataat ggccccgatc 2734021 actacaattg ccccaataat cattaaaatg gtacgaagca taagatcaca tctcctcttc 2734081 actgtcatgt actttaccat gccctgccgg agctgtttta aaacctgaaa aagagcgccg 2734141 gcatgaagct ccggcgctct tgcgcgatta agaatcagca cgcagcgtaa gtaagacgac 2734201 tgacattggc gggagtttta ctttcagttt gtttttgctg agcgtgtatt gtctgaagga 2734261 ttccggtttg acatgatgag gatcgtcaaa cgtgttatgc gcattcattt tttctgccgt 2734321 aagaatgact ccggaatggt ccgctgcctt gtgtaggccc ctcagctcga tttccgcctc 2734381 tgctttgttt tggtgatcga tgttgcaaat tgtgatattg atatcgcctt cagcttgttt 2734441 cgacgctgaa atgctgattt gcggaagcgt ttcaccgttc cattcatagt cggcagacat 2734501 tgtctctgtg gctaaaagag aagcgtcctg gtgcacctta aacatattga atacatggta 2734561 cgtcggtgtc aaaagcatcc gctctccctc agtcaaaatc atcgcttgaa gaacatttac 2734621 tgtttgggcg atgttggcca tttgcacccg gcggcaatgc tgatggaaaa tgtggaaatg 2734681 agaagccgcc accagtgcat cacgaatggt gttttgctga tataagaaac cgggattcgt 2734741 gcctggctcg ggatcaaacc acgtgcccca ttcatcaata atcagcccga cccgctgctc 2734801 cggatcgtac cggtccataa tcgtgccgtg tttttgaatc aattcatcga tgtatttggc 2734861 ttttttcatc gtaataaacc attcatcttc cgtgaattct gtggctgatc ctttgccctt 2734921 ccagaaatcc cccggaatcg tgtaataatg aagactcaac ccgtccatca ggccagcggc 2734981 ttttttcata agcacgtccg tccaattaaa atcatccaca tttgcgccgc ctgcaatttt 2735041 ataaatgtca ttcccgctgt aattgcggac ataagtctga aaacgccggt acagatctgc 2735101 gtagtattcg ggatgcatgt tgccgccgca gccccagttt tcattgccca cgccgaaata 2735161 tttcagcttc caaggctctt ctcttccatt ttgctttctc cagtctgaca tcggcgtgcc 2735221 ttcttcaaat gtcatatact caatccactc cgacatttcc tgaacggttc cgcttccgac 2735281 attgccgcaa atatatggct cgcattcaag cagctcgcaa agcatcataa attcatgcgt 2735341 tccgaattca tttgattcaa ttgtaccgcc ccagtgagtg ttcagcattg tcttacggtc 2735401 accgacaccg tttgcccaat ggtattcgtc cgcaaaacac ccgcccggcc acctaaggac 2735461 aggaatgtgc agctgtttga gcgcctccag cacgtccttt cgtatcccgt tgatattggg 2735521 gatgtctgag tccgttccga cccagatccc ctcataaatc cctcttccta aatgctcagc 2735581 aaaatgaccg tatatatttt tgttaatggt tccttttgcg atatctgttt gaatcactgc 2735641 ttgatgttca gacatgcctc tgatcattcc tttcatacgg atatgaaaag caccacagtc 2735701 aaatatgtga tctgtcgttt gcctgaggag tcagcatgaa tgtaagcgct tttaaagtaa 2735761 ccatattata tatgttcgta catgtcaacg acattttcta ttgtttttat atttgtacgt 2735821 atgtatttat aaatatgaaa aaacccggac ttttaaagtc cgggatttcc tttatgagtg 2735881 tatattcagc tgtttgaatt cctcagttaa taacgggaca acttcaaata aatcaccgac 2735941 gatgccgtaa tccgctattt taaagatatc ggcttcgggg tctttattga tggcgacgat 2736001 caccttgctg tttgacatgc cggccaaatg ctggatggcg ccggaaatgc cgcatgcaat 2736061 gtacaaatcc ggagtaacga ctttcccggt ctgcccgatt tggagagcat aatcgcaata 2736121 atcagcgtca catgccccgc gagaagcccc gactgcggcc cctagcacct ctgcaagctc 2736181 ctgcagcggc tgaaatcctt ccttgctttt gactcctcgg ccgcccgcaa cgataatttt 2736241 cgcttcggag agatcaacac cgtccgccgt ttttttcacg acctcttgga taacagtgcg 2736301 gaggtcagta agagaaacat caatgctttc gatgctcccc gatctgctgg tgtctttttc 2736361 tgaagcttga atgttattgg ggcgaattgt tgcaaagatc atcggatcgg ttgaaatgac 2736421 gcgttcaaaa gctttccccg agtaaatcgg ccgtgtgaac acaacattcc ctccggtaac 2736481 gcttacatct atagcatcag aaattaagcc tgtttgcaga cgggcagcaa gcttcggtga 2736541 aagatccttg cccattgccg tatgcccgaa gatgactgaa tcaggatttt cttgctcgat 2736601 aacacctctc atgacctggc tgtacccgtc tgccgtgtat gttttcagct tcgggtcctc 2736661 agcggtaaga actttatctg ctccgtaatg aataagctct tgtgcaatgc tttgtacatt 2736721 ttcaccgatg agaacaccga tgacttcccc atctcctgaa atggttcttc ctgcagctat 2736781 tgcttcaaag gtgacatttc gcaattcccc atcgcgtatt tctccaagca cgatcacttt 2736841 ttttcccatt ctaacatccc cctgtttctt tgaatgtcca agttttaaat gactttagct 2736901 tcgctgcgga gcaatgaaac aagctctttt gcctgttcag caggctcacc ttggagaagc 2736961 ttcccggctt cttttttcgg cggcagaaaa cgttcaatgg ttttcagctt tggttcagca 2737021 tcctcttcgt ccagatcaag atcatcaagt tcaagctctt caagcggctt tttcttagcc 2737081 ttcataattc ccggaagcga tggatagcgc ggctcgttta agccctgctg agctgtgaca 2737141 agcaatggga gcgtcgtttt gattttttca acatcccctt cgacgtccct ttctgcttct 2737201 gcatcagtgc cgttgatttc gagtttggtg atcgtagtga tacacggaat gtccagtagc 2737261 tcggcaagcc gaggcgccac ttgtcctgat cctccgtcaa tggcaacatt tccgccgaga 2737321 atcaaatcaa actcctgatc cttcatatag tggtataaaa cttgagaaat ggaatattgg 2737381 tcgggttcat caagatcatc ttctatgttg attaaaacag cttggtcaca acccatggca 2737441 agcgccgtac gcaattcttt ctccgcttct tcaccgccga ccgtgacagc ggtgatcgtg 2737501 ccgccatgct tttccttcag ctggatggct tcttctatcg cgtactcatc atatggatta 2737561 atgatccatt ccgctccgtc atcctgaatc tttcctgttt caatgacgat tttttcttct 2737621 gtgtcaaacg tccgtttcat cagtacaaat agattcatga tcatatcccc ttttattcgc 2737681 ctttgaactg aggctttctt ttttcgagaa atgcctggat gccttccttg gcgtcctctg 2737741 actcaaatgc ttccccaaat cgctttgctt caagctttaa gctgccttca taggaataca 2737801 ccttgttgga ataaagaagt tcaagcaaag atgccagcgt ttgcgggctt ttctctgcaa 2737861 acttagcggc aagtgctttt gctttttcaa tcacttctgc ctcatctttc gctccaattg 2737921 agacaagtcc gagatcaagc gcttcttttc cggatatcgg ttctcctgat ccgatgagct 2737981 ccagtgcttt ggctgtaccg acatatctcg gaaggcgctg tgtccccgca aaacctggaa 2738041 tgataccgag attaagctcc gggagcccca gcttagcatc ttctgccgcg attctgatgt 2738101 gacaggccat tgcaagctcc agcccgcctc cgagagcagc gccgtgaatc gctgcgataa 2738161 tcggttttgg aaaactttcg attctctcca ttaactgctg gccgcgctca gcgagcaatg 2738221 aggaatcctc attgccttta agcgatgtaa attctttaat atcagcgccg gctgagaaaa 2738281 atcttccctc gccgtgaatg ataatgcttc gtacgcctgc atctgtctca cattgatcaa 2738341 gacaggaaga cagctcttct aatatccggc ttgaaagcgc gtttgccggc ggattgtgaa 2738401 tcgtcaagac tgccacaaat tgatcaaccg caagtgaaat tgcattcata ggacagaact 2738461 cctttactta ttgtgaattc cggataccaa taattctaaa acgctgtttg aaagcgcaac 2738521 gagatcgtac ttttggtcat tcatcaccca agttgtcaca gtttcgtcaa tcgttccaaa 2738581 aatcatctgc cgggcgaggc ggacatcgag gccttctttt atttcgcctg attgtatacc 2738641 ttccgtcaaa atgccatcca aaatatttaa gtagcctttt aatatttcgt tgattttttg 2738701 gcgcagctcc aagttggatt ggcggagctc aagctgcgtg acaatggcga gattatggtc 2738761 acccgctaaa agggaaaaat gctttgaaat cacaagcgcc aatttctctt tcgctgttgc 2738821 tttttcttta atgtcctctt ccatccgctc aataaattga cccatttttt ctttgaaaag 2738881 agaaattaaa atatcttctt tgtttttaaa atagagatag atggtgccgt ccgctacccc 2738941 ggcttgtttg gcaattttgg atacctgtga ctggtggtag ccgttttctg caatgacttc 2739001 tactgctgca tcaataatct gcatatactt tggccgtttt tgcttcaatg ttcatcgttc 2739061 cttcctatag aaatgaatga ctattcattc ataatttcat gataagaagg attttcaggt 2739121 ttgtcaagtt tattcatagg cgttctcttt ttttatttga tatgatgatt ttcggtttct 2739181 tcttcaagta aacgccttct taaaattttt cccaccgccg ttttcggcag ctcctttctg 2739241 aactcatagg ctttgggcac cttataggga gctagacgtg atctcgcaaa agcgtccagt 2739301 tcttctgtat cggcttttgc gcctttcttt aatacgacaa atgcttttac tgtttctccc 2739361 ctgtaggaat cgggaacgcc tgcgacaaca atttcctgga tggcttcatg ttcataaagc 2739421 gcttcttcta cctcacgcgg gtaaatattg taaccgccgg caatgatgat atccttcttc 2739481 ctgtcagcaa tatagaaaaa gccttcttca tccatatagc ccatgtcccc ggtgaacagc 2739541 cagccatctc tcagcactgc ggcggtttcc tctggtttat tccagtatcc tttcatgact 2739601 tgcggacctt ttacaatgat ttctccatgc tcatacggag cggcaagctc acccgtctct 2739661 tcagaataga tcgcagcgtc cgtactcggc caaggacagc cgatactgcc cggcttgttt 2739721 tttccccaga taaagttggc gtgcgtcact ggggatgcct cagacaaacc atagccttcc 2739781 acaagctttc caccagtcac cttttcaaat ttctgcttta cctccacggg gagcgcggct 2739841 gatccgctaa gacagctttt aatggatgac agatcataat gctgcaattc agggtgatgc 2739901 aaaaggccaa tgtaaattgt cggtgcgcca ggaaagagcg tcggtttgtg tttgtcgatg 2739961 attttaagtg tttcgagcgg atcaaactta ggaagaagaa tcatttcgaa gcctagttta 2740021 atcgaatagt tcatgactgc cgtcagtccg tagacatgaa aaaatggaac gatgcccagc 2740081 actttttcag cgccttcttt cacgtcatac atccaagcgg cgcacatttc agtatttgcc 2740141 aaaatatttt ggtgcgtgag catgacccct tttggagctc cggttgttcc tccggtatac 2740201 tggaggacag cgatatcatg ctcaggatcg atcttcggga ttgtcaggag ttcagttttt 2740261 tcctgcttca tacaggaagc gaacgtgtga atgttagctg ttttgtcaaa gtcgatatgc 2740321 actttttgtt tttgcgtcag cgggtaaaga atatttttcg gaaaaggcaa atagtctttt 2740381 acactggtta tcaaaatctg gtcgactatt gataacgttt tcatttttat tgccttcggg 2740441 aaaagcaaat ctaaggtgat gattacactt acctgagcat ctctaagctg gtattcaagc 2740501 tcatgctcgg tataaagcgg attcgtctgc accacgatgc caccggcaaa caagacgcca 2740561 taataagaaa tcactgtttg cgggcaattg ggcagcataa cagccactct gtctcctttt 2740621 tgcaggccat tgcactgcaa aaaagctgca agtttaagag catccgtcag aatgtcatga 2740681 aaggtgagtt tttttccata aaacgatatt gcggttttat cagggaatcg tgcggcggag 2740741 tctgtcagga tggattgcag ggttttattc ggcaacggaa gctcatgcgg gatatcgttg 2740801 ggatactcgg caagccacgg cttttgagac tgcataaaac ctcccctttc gattttagag 2740861 atccacctta tcattatagc agatggacgg caaaaaaaag aaaaagaaag gtaaatcttt 2740921 ctttttctca taatatgaac agatatataa gaccaattaa caaaaagatt cccgctgcgg 2740981 cgagcagtat tttcgcaagc ttttccatct attctccgtc cccttatatt ccggctgcca 2741041 ccacaaaaga aagcccgaca gaaatgacaa atgaaataaa gccgacagcc cggttatcat 2741101 tttcgatttc ctgatcaatt ttaaaccgcg gagtcaaaaa ctcaaaaata aagtagctga 2741161 tcagaagcat aacaaacccg taaacgcccc agccgatcat ttgcagcagc gaattatgct 2741221 gggagatgga atgctgaaat acgtttgcga ttcccaaaat ttttccgccg gtcgccattg 2741281 ccaccgcaag atttcctttt tgaatctctt cccagttttt ataagccgtc accagctcaa 2741341 acacagtcaa aaagaggacg aggcagagaa ccgcgacact gtaatatgcc gcgatttcca 2741401 caagctcgtt ttcccaaaaa tcactcatgg ccatactccc ttttatttta gttcaacaac 2741461 cgtaacgcct gatcctccct cacctgcttc accgaaacgg gaacttttga cgctgcggtg 2741521 gtttttcaga agatcctgta cgccttttct taaagcgccg gttccttttc cgtggatgat 2741581 tgacactctt ggatatccgg ctaacaccgc atcatccaag tatttttcaa cccggctgag 2741641 ggcattttca tagcgttcgc cgcgaagatc aagttcaagc gatacgtgat agtcctttcc 2741701 tttgaccgct gtaatcattt tttctttttt tggctccgga gctgatttga taaactccag 2741761 atctttttct tttactttca tctttaaaat accgatttga acgttccatt cattgccgcc 2741821 tgttttttcg agcaatgttc ctttttgccc gaaagtgagg actttcacct cgtcgccagg 2741881 cttaaagtcg cgtttttgcg ttttcggctt ttccggtttc ttggactttt caaaagcagg 2741941 catagcgcct tctaaccgtt tcttcgcgtt aatcagctcg tgatccttga aggatttgtg 2742001 ttcttctttt atggtgcgca attcatgaat aatgtcctcg gcttctttca ttgccgcttt 2742061 tactttttca gcagcctgct gttctgcctc ttcaagcatt ttgtcttttt tgctgttaag 2742121 ctcgatgatt tgctgctgca gctctttatg cagtttttcc gcttcttttc tgattgattc 2742181 tgtctcagaa agctcttctt ccgcacgttt tttgctttgt tccagcgacg caatcatcgt 2742241 atcgacttcg ttatgctcgg ccgtcatttc tgacttcgcc tgcccgatga tatggtccgg 2742301 gagcccgagg cgttttgaaa tttcgaaagc attgcttcga cccggcacac caattaaaag 2742361 tttataggtc ggtgacagcg tttcgatgtc aaattcaacg ctggcattca tgacgccttc 2742421 tctgttatag ccgtacgcct tcaattccgg ataatgcgtc gtagctaaca ctcgtgcatt 2742481 ggtgcgatgc acgtcatcca agatgctcat ggcgagggcc gccccctcct gcggatctgt 2742541 ccctgcacca agttcatcga aaagcacaag gctgttttca ttgacctgtt ctaaaatgcc 2742601 gacaatattc accatatggg atgagaacgt acttaaactt tgctcaatcg actgttcatc 2742661 accgatatca gcgaatacgt gctcaaatac tgccgcttct gacccttcat ctgccgggat 2742721 atgaagacct gactgcgcca ttaaggttag caggcctaac gttttaaggg tgactgtttt 2742781 ccccccggtg tttggccctg tgatgacaat ggttgaaaaa tcgcggccaa gctcgatgtc 2742841 attggcaaca acctgatcag gcggaagcaa tggatggcgg gcttttttca aacggataaa 2742901 gccggtgtcg ttcataatcg gttttgtcgc tttaaccgct tttgcatatc tagcttttgc 2742961 aaaaataaag tcaagcgtct gcagcacttg caaatctaga aatagctcct ctgtatactc 2743021 tgccgttttc tctgtcagca cacgcaaaat ccgttcaatt tcttgctttt ctttcacttt 2743081 cgcctgctga agggaattgt tcatatctac aatcgcctgc ggttcaatga atagtgtcgc 2743141 accagaggat gaggtgtcgt gcacaattcc tccatagctg gatctgtact cctgtttgac 2743201 cgggatcaca aagcggtcat tccgaatcgt aacaatcgta tcagacagca ttttcgatgc 2743261 ggaagaggaa cgcagcatcg actctaaccg gtctctgact cttgattcga gtgttctgag 2743321 ctgtgtgcgg attcctctta atgtttccga tgcatgatca agcacttctc cgtgatcatc 2743381 aatgcaggaa ttaatgtccc gctctaaatc ggacagcgtg ataagctgtt cagcatgctg 2743441 atggatcagc ggaatgtcga caccgtcttc agccatttgc gtgataaaat gtttcatttg 2743501 tttaactgca taaagcaggc ctgagatttc agtgaattca gaaggactga gaacgctgcc 2743561 gatttccgcc cgtcttaacg ctcctctgat atctacaagg ccgccaaatg gcgcttggcc 2743621 tctcagccgg ataatgtcag aagcttcgtc tacttcatcc agctgttttt tgatttcgtc 2743681 tatagaagca gaaggcttaa gctcgagaag catttctttt ccgagcgatg aagcggcatg 2743741 cccaataacc tgttctttca ctttatgaaa ttcaagagct gataatactt tttgctgcac 2743801 gattgtgtga gcctccttac ttaatcgttg cgcttcagaa atgcctctac gtctttaagc 2743861 gaccgggcat tcagaacgtt tttcgtttcc gtccatcctt tgcgcgcggc agtaacgcca 2743921 gttttcatat cgtctaacat ctcaatatta tgggcatcag tattaatcac caatgtaacc 2743981 ccttgttcgt ttgctttcat taaatgctct gtgcgcagat caaggcgcgc agggttggca 2744041 ttgagttcaa gcgccgtatt tgttttcctc gcaagctcaa tcagctgatc aatatcgatt 2744101 tcgtaaccgg cccgtctgcc gataaggcgc ccggtcgggt gtgcgataat gtcaacatgc 2744161 ttgtttgtca gtgccgtctc aagccgtttc ataatcacgt gttccggctg attaaaactg 2744221 gaatgaatcg atgcaataac gatatccatt tccgcaagca catcgtcatc ataatcgagc 2744281 gtaccgtcag gcaggatatc catctcaacg cctttcaaaa tacggaagtt ttcaaactct 2744341 gcattcagcg cgtcaatttc ttttgcctgc tgcttaagtc tttctgcagt aagcccgttg 2744401 gcgaccttta aatattgtga gtgatcggtg atcgccatgt attgatagcc ttttttgatg 2744461 caggcttcag ccatctctct gatcgaaaat gcgccatcgc tccacgttga gtgcatgtgg 2744521 agatcacctt tgatttgccc gagctctatc agttcaatgc tgtcgctgta ggtttccact 2744581 tcctgtccgc tttcacgaat ttccggcgga atcagcggca ggccgaagtg cgcataaaat 2744641 tcacgttcac tcggaaatgt tttgatctct ccggtttcaa ctgtctcaac gccgtattca 2744701 ctgatccgct cgccgcgttc tttggcgatt tggcgcatct taatattgtg atcctttgat 2744761 cccgtaaaat gatggagtgt tgtcggaaac tgctcttccg tcacaagacg gaaatcgacg 2744821 cttgtttcat attcaaagga aaggatgacg gacaccttcg tatctccgct tgcgatcacg 2744881 cttttgatgt ttggcagctc aagaagctgc tctcttactt cagccggatg atctgtagca 2744941 atgatataat ccagatcctt caccgtttcc cgcgctctgc ggagacttcc ggcacgagaa 2745001 aatttgatga tatgcgtaaa ttgagaaaga tgctcctcaa tttcccgcgc gatccggagg 2745061 gcgtagccga tcgggaaccg ttcaggctgt tttccggctt ccccgagcgc ctgtaatatt 2745121 ttttcttccg attttttgcc gaagcccgca agaccctgga ccttttgctg ctcacaggct 2745181 tccttcagag attctgcatc gtgtacgccg agctctttat acagctttgc gatttttttg 2745241 ccgccgagcc ccggcagctt caataaaggc acgagtcctt ccggcacttc tttctgaagc 2745301 gattcgagcg tgcttgactt tccttcatct atatactctt taatgacgct gtacgttcct 2745361 tttccaatgc cggacagcga catcatatcg tccatttctg ataagcttcg gtcgtcctgt 2745421 tccagagctg ccgccgcttt tcggaaggcg gatactttaa acgggttgtc ccctttgagt 2745481 tccatataga ctgcaatggt ttcaagcagc cggataatat cttttttatg catatcataa 2745541 cccccagacg ttcacatatg tttccatcat acttgaaaaa aacttctccg gacaagagaa 2745601 gtttttttat gccccgtact gtgtccacag ctcttgtaaa agccctgaca agtacggtgt 2745661 atggttaatg atcacatttg cgagagacga ttgccccatc atttgctgca acgcgtctac 2745721 cggcagaacg gatgcgacat acagcagcac aaatgtaaat aaatagactt ctagaaaacc 2745781 gagaacggct cccagcatct ggttgatttg tttaatcacc ggaatgccgg ctacaatact 2745841 caggaacgag ccgatgattc tcagtaagat tttagcaatg ataaataaaa cgataaacgc 2745901 aatcgcatta tagtacgctg cttccaaatt ccccgtaaaa aaagaaagag ccggctgtcc 2745961 cgctgaaaaa tcgggtgcgg gaatccaatg taaatgcggt gccacgtttt tatagaataa 2746021 agccgcaaag gcaattgata aaataaagct cgtcaagcgg ataaactgca ggataaaacc 2746081 gcgttttaac cccagtaaag tccccatcag gagcaagatt aagatgatga tatctagcat 2746141 agttgttcaa tccttttctt taagctgacg ctccagtttt tcacatttct cttgtaattt 2746201 gacataatcg tgcaccacat ttaccgctgt cagcactgca agtttattta tatcaaggta 2746261 tggatttttt tcattgattt ctctcatttt atcatcaaca attccggcga catacctcat 2746321 atgggctctg ctttcttcac cgacaatcgt gaagtgctgg ccgtaaatgt caacggttgt 2746381 ttttgttttt ttgccgtcag acaacgtttc tcctccattc cgcgagaatc ctagttctta 2746441 tcataacacg tttattaaat gaatggaaag acgagcctcc cgctgttatg atacactggt 2746501 atatacagcg aaaagtgtaa aaaaaggaga ttattacgtg tcccattcag tgataaaagt 2746561 atcgttgtct gctattgacc aaatgaaaat gacgtacagc ggttcactta cagcctctgt 2746621 tccgcaggga gccgtttttc aggcaaaacc gcccggctgt accattacag catatcaatc 2746681 aggtaaggtc ttgtttcaag gaaaaaacgc tgcggcagaa tccgcgcgct ggggaacagc 2746741 agagcctcag gaaaagaaga aaacggccaa aaagccggct gatccccgct atgcccctcc 2746801 ggcagatatc gccggaatgt ctgttatcgg ttctgacgaa gtcggaaccg gagattactt 2746861 tggcccaatg acggttgtat gcgcgtacgt cgacaaaacc atgcttcctt taatgaagga 2746921 actcggtgtt aaggattcta aagatttaaa agatccgcaa atcatcgaga ttgcccgaaa 2746981 cctgattaaa accattccgt acagcctgct ggtgttaaag aatgaaaagt ataacagcat 2747041 gcaggaaaaa ggcatgagcc aagggaaaat gaaagctttg ctgcacaatc aggcgatcac 2747101 acatttatta agaaaattgg atggagtaaa gcctgaagcc attttgattg accaattcgc 2747161 tgagccaggc gtctacttca atcatttaaa gggcagagac attgtgaagg agcggaccta 2747221 ttttagcaca aaagctgaag gtattcacct ggctgtcgcc gctgcttcaa tcattgcaag 2747281 atattcattt ttaatggaaa tggataaact atcacgcgcg gcaggaatga cgcttccaaa 2747341 aggggccggt ccgcacgtcg atgaagcggc cgccaagctg atcctcaaaa aaggggcatc 2747401 tgcactcaga acctttacaa aactccattt cgccaatacg caaaaagcgc agcgccttgc 2747461 tgataaaaaa cgttcataga aaaaagcttg cagatttctc tgcaagcttt tttatcagcc 2747521 tcttaaaaca gcttgatatg tgtcttctaa cgctttcagc actttgctgt gcgcctttgt 2747581 cacttcttct tcagtcagtg tttgttcagg attgacatac tggagtgaga aagcgactga 2747641 cttcttgcct tcctccatat gctctccttc gtatacgtca aatacggtta cctctttcag 2747701 aagcttgccc ccggcctctt taatgacgct ctcgagctgt ccgcttgtga cggttttatc 2747761 tgttacaaga gcgatatcac gtgtcacaga cggatatttt ggaatcgccg tgtaaacaag 2747821 cggtgctgtt tctgctgcga gcaacgcatg aagatcgagc tcaaatacgt atgtttcctt 2747881 tatatccagt tctttttcca atgaaggatg gacttggccg atgaagccga tcagagaacc 2747941 attcaataaa atgttcgctg ttctgcccgg atgcagctgt ttgcgttcag actgtacaaa 2748001 ttcaatgctg tctaggacgt tgagtttgtc taacagccct tccacaattc ctttgacaac 2748061 aaagaaatca actggtttct tttcaccctg ccatagctgc ttgcgccata atccggtaac 2748121 agctcctgct acgcgttctg tttcaacagg ttttgtgtcc tcttccttcg ttaggaaaac 2748181 ggagccaact tcgtacagtg caactgagtc agtctgcctc gcaagattgt aagaaacaga 2748241 atcaagcaga tttggaacaa gactgtgtct gagaatgctt ctttcttcac tcattggaag 2748301 cgcaagcaca gtattcagtg atttttcaat cgcaaacgct gtcgctttct tctcgtttgt 2748361 cagtgagtaa gtgatggctt gtgataagcc tgcgccttca aggaagcgtc tgactttacg 2748421 gcgttttgcc tgatatggcg ttaatccgcc tgtagttccc gctgtctcag gaagcgtaga 2748481 cggaatgtta tcgtagccgt acagtcttgc cgcttcttcg attaaatcct cttctattgt 2748541 aatgtcaccg cgccgtgatg ggacagtcac aacgagaaga tcatccgctt caccgaccgt 2748601 aaaaccgaga cgtttataaa tgctgatcag ttcttcttta ctgatcgtca ggcctagaac 2748661 gctgctcact ttgtcagcag atacgtgaat gttatttgct tcgattgtca ggtgatcttc 2748721 ctcaaccgtt ccagcaagca cctcaccgcc ggcatacaga tggatcagct gcgcagcccg 2748781 ttctgctgca agacgtacgc gtgccggatc aattcctttt tcaaatctta cgcttgattc 2748841 acttctcaaa ccaaggtctt tggaagcctt gcgaaccttc tgcccgttga aatacgcagc 2748901 ctcaagcaaa atggttttcg tatcttcctg aacctctgac tctgctcctc ccatgacacc 2748961 ggcaacggcc tgcgctttcg ttccgtttgt aatgacaagg tgatcggcag acagcttacg 2749021 ttcttgatca tcaagtgtta cgatcatttc attctcagct gcttttctta ctacgacttc 2749081 cttagagcca aatctgtcat aatcaaacgc atgaagcggc tgtccgtatt ccaacaggac 2749141 aaaatttgtg atgtcaacga cgttgttgtg cggacgaatg cctgcattca tcagctttgt 2749201 ctgcatccaa agcggtgacg gagcaatcgt gacattttta atgatttttg cagtgtacag 2749261 cgggttcgct tcttgatctt caattttgac tgaaatgtaa tcagacgctt gttctgaagc 2749321 agccgggtaa tccgtttgcg gaagctttac ctcagtgtct aaaatcgccg caacctcgta 2749381 agcaacacca agcatgttca tggcatccgc gcggtttggc gttaaaccca gctcaagaat 2749441 cgcatcgtca agctgtaaag ccgctaaggc atcgcttcct gtttcagcgt cattcgggaa 2749501 tacgaaaatg ccttctgcat actccttcgc cacaagtttg ctttcgatac caagctcctg 2749561 taaggaacag atcatgccgt ttgattcttc accgcgaagc ttggcttttt tgattttgaa 2749621 attgcccggc agcaccgctc cgactgttgc aactgcgact ttttgtccct tatccacatt 2749681 cggcgcgccg caaatgattt gtacaggggc ttcagctccg atatccacaa ggcacttatt 2749741 cagcttatca gcattcgggt gctgctcgcg ctccagcaca tggccgatga caacgccttt 2749801 gatgccttct cctttgtatt caattccttc aacctcaata ccggctcttg taattttttc 2749861 agcaagaaca gccgggtcca tgccttttaa atcaacataa tcctctaacc atttataaga 2749921 aacaaacatc cttgcatcct cctcttacgc ctgtttaaac tgcgaaataa atctgacatc 2749981 gtttgtatag aagtggcgga tatcatcaat gccatatttc agcatcgcga tgcgctcaac 2750041 acccattccg aatgcgaagc cctgatattc cttcggatca aagccagcca ttttaagcac 2750101 gttcgggtga accattccgg caccgaggat ttcaatccag cctgttcctt tacatactga 2750161 gcagccgttc ccaccgcatt taaagcatgt cacatccact tctactgaag gctcagtaaa 2750221 cgggaagaag cttgggcgga gtctgatttc acggtcttgc ccgaacattt ttttcgcaac 2750281 aagttcaagc gttcctttta aatcactcat gctgatgttt ttgtcaacga caagcccttc 2750341 aatttgcata aattggtgag agtgcgtcgc atcatcgtta tcacggcgat atactttacc 2750401 cgggcaaatg attttaacgg gacctttgcc ttcatgcttt tccatcgtac gtgtttggac 2750461 aggagaagtt tgcgttctca tcaaagtttc ctctgtgatg taaaagctgt cctgcatatc 2750521 gcgcgctggg tgttctttcg gaagattgag cgattcgaag ttgtagtaat ccgtttcaac 2750581 ctctggccct tcctcgactg tgtagcccat accgataaat aaatcttcaa tttcttcaat 2750641 gacaacagtg agcggatggc ggccgccgac tgcaacaggg ttccccggca gcgtgacgtc 2750701 aattgtctgt cctgcaagct tctgtttcat ttcctcttct tcaagcttct cgtttttgtc 2750761 agcaatcgca ttggcaatac gctcccttac ttcgttcgcg agcgccccca tttttggacg 2750821 ttcctcagca gaaagcttgc ccattccgcg cagcacttct gtaatcggcc ctttttttcc 2750881 gagatattgc acccgaatat cattgacaac cttcaatgag cttgccgctt ctacttgttc 2750941 taaagcttct tgttccagct gttttagctt ttcttccatt ttgcatcctc cttttatgta 2751001 aacaaaccgt catatgtctt tggaaaataa aaaaaacccg tcccttgtac aagggacgag 2751061 ttgtggccgc ggtaccaccc ttatttcaga cagactgatg ctgtcgtcag cttcattgac 2751121 ataacggaat cagattccgg ttcaccttta cgcgcagtgt acgcggtccc ggcgacaact 2751181 caagaggtga agccaatttc cggctgcgtt aaaaatgctc tcagtcagcg gcattttctc 2751241 cctggaaagc agttgatcag aaattgaggt cctctgtcac ggtttttgaa atattatgtt 2751301 ctattataga gaaatccaac gcttggcgca acactatcct cgcaagtgat acacgaggat 2751361 ggcagccgca accgcaacgt ttagtgattc agcctgtccg taaagcggca cgtacaggtt 2751421 caaatccgtt ttttccagca atgcagcatc tacccctgca ccttcatttc ctacaatgag 2751481 cgcaaaggat tcagactgag gaatctcctg gtaaggcgct ccgttttgca gcgccgtgcc 2751541 gtatactttt acgccctctg ccttcaattc gtccacatat gaaggcaggt ttcttctcac 2751601 aacaggaata tggaagtgag atccttgagc agatcgcagt gtttttccgt taaaggcgtc 2751661 cgccgtgccg tcaccgagta caaccgcatc caaaccggcc gcatcagccg ttcgaatcat 2751721 tgtgccaagg tttcccggat cttgaacagc gtcaatcagc agcaccttgc gtgccgttgc 2751781 cagcttttct tcaggcatat ggcacacagc ggcaatctgc tgcggcgttt cggtttcagt 2751841 cacagctgaa aacgcatctt cactcagcat atagcactgg ataccagtct caagatctga 2751901 aggaatcctc gtttcatcct ttacaaggat ttctttcaca atgcccgggc ttttcaacgc 2751961 ctcttcaacg aggtgttctc cctctatcag aaatgtattt gtttttgttc gttctttttt 2752021 tgtgtgaagc tttttccaat ccttcacttt ttggtttttt gccgattcta tttgtttcac 2752081 tgtctatgtg gcgctccttt ttttaacatg atgttattat atcgcaagaa cagcacataa 2752141 taaaccaggt gcagggttag aatatacgta ttacatttta gaaaaaggag cgttttacat 2752201 ggatcttaat ttacgtcatg ccgtcattgc caatgtcacc ggcaataatc aggagcagct 2752261 tgagcataca atcgtagatg cgattcaaag cggtgaagaa aaaatgcttc cagggctcgg 2752321 cgttttattc gaagtcattt ggcagcacgc atccgaaagt gagaaaaacg aaatgctgaa 2752381 aacgcttgaa ggcggattaa aacccgccga ataagacatg aaaccgggtg acagcgcccg 2752441 gtttttttct tatataataa aaacatgatg agggggaacg ccatgttttt acagccgtta 2752501 ttagcgaaaa aaattattgc tgaagttaaa aaaatgtacg aacgtgaagt cattattgta 2752561 aacacggacg gtcttattat ggcaggcaca aacgatgagc gtgtcggaca atttcatgag 2752621 ggagcgctta tctgcgcaaa agaaagacgc agcgtgatta ttacaaaaga agatgaaaca 2752681 aggttaaaag gagtgaaagc aggcataaac ctccctgtat tttttgacca tgatgtgatt 2752741 gccgtcttcg ggctgacagg tgagcctgca gagattcagc cattcggaga actgcttcga 2752801 aaaatgacag aactgttcat taaggaatcg cggcacttag agcaatccca gtggcgtgag 2752861 agaatgctgg agtcctttat gatcgattgg ctgcaattaa aggagtggtc tcccagtttt 2752921 cttgagaaag ctcagcttct tggtgttgac ctttcttccc ggcgccaaat gattcttatt 2752981 caggggtatg agtggtcacc tcatgatatt gaacaaatgg cacgcagctg gaaatcctcg 2753041 taccctgcgg atttgttcat caggtgggga aatgaacgga ttttgattaa tcatgaagtg 2753101 ccgcagcatg aacaaaggga tcggcttttg cggaaaatcc ttcacatttg ttcgtttgcc 2753161 aataccgcaa gcagccaata tacagcagct ggcgccggaa gggctgtcgc aagctccagc 2753221 ctgacagatt catacgagca agcggaaaaa gcgctggctg tcagccttaa gcgaaaaacg 2753281 cccatatttg aagaggatct gaagcttgat atgtgtctga cggagatcag cccgggaacc 2753341 cgaaacgaat ttccgcaaag agtattagga aaggcgctag agcatcagga acttatgaat 2753401 acgatacgga ctttctttca tcacgatttg tctttgaaac aaaccgctga agacatgcat 2753461 atacacatca atacattgcg ttatcgtctg gctaaggctg aacagctgac gggattacgt 2753521 tttgaccgta ccgaggacgt cgtcacgatg tacgtcgcac tctatttttt agatcaagat 2753581 acaaaataga gagagtttca gtttcatttt ttgtatgttt ctccatggaa ggctttgctt 2753641 tttttctttt acaatagatt gaaagcgttt tttgacaggg ggatgggtga aatgatcacc 2753701 aaggatgtaa aggagcagct gattcaggtc tccggaccag aaaactttga tgactcgaat 2753761 gccggccgtc tcgtctattc atatgatgcg acgcctcagt atcagtctat gcctgatgcc 2753821 gtgattgctc cgaggaatac tgatgaaata tcacgcattt taacaatttg cagcgaacat 2753881 cgagtgccga tcgttccaag aggatcaggg acaaacctgt gcggcggcac gtgcccgact 2753941 gaaggcggac ttgtgcttct ctttaagcac atgaaccaga ttcttgaaat tgatgaagaa 2754001 aatttaactg ccacagttca gccgggcgtc attacgttgg atatgatccg ggcagttgaa 2754061 agcaaaggtt tattttatcc gcctgacccg agttctatga aaatatcaac tatcgggggc 2754121 aacatcaatg aaaattccgg cgggctacgc ggattaaaat acggtgtcac ccgcgactat 2754181 gttattggac tggaggttgt tctcgcaaat ggtgacatca tccgcaccgg cggaaaactc 2754241 gcaaaggatg tggccggata cgatctcaca cgtctttttg tcggctcaga aggaacactc 2754301 ggcattgtga cagaggcaat cgtcaaactc gttccaaagc cggaaacaaa gaagacgctg 2754361 cttgcccttt atgaaaacat cgatgccgct gctcaaacgg tatcggacat tattgccgca 2754421 aaaattatac ccgctacgct tgaatttctc gatcagccta cactattggt gattgaggat 2754481 tatgccaaaa tcggacttcc gacaagcgca aaagcagttc tgttaattga acaagacggg 2754541 ccatttgaaa ctgttgaacg ggatatggaa aagattgagg cgatctgcaa aaaaggcgac 2754601 gccgtatccg ttcagaccgc acaaacagag gaggaagcgt ttgccctgac tgaagcccgg 2754661 cgttctgcac tttctgccct agcccgcctc aaaccgacga cgattttaga ggatgcgacc 2754721 gttcctcgct cagaaatcgc caatatggtt aaagcgatta atgatattgc tgctaaatat 2754781 gatatttcca tctgcacctt tggtcatgcg ggagacggga accttcaccc gacatgcacg 2754841 acagacataa gaaataagga tgaaatggaa cgtgtcgaac aggcttttgc cgagattttt 2754901 gagaaagcga ttgaacttgg cgggacgata accggagagc acggagtcgg ggaaatgaaa 2754961 gcgccttact tggaaatgaa gctgaaaaaa gaaggcattg atgcgatgaa agcgttgaaa 2755021 gcggcatttg acccccggaa catattaaat cccggcaaaa tgtttgcgaa agatgccaga 2755081 aaacgtgtgg tggcggaaag atgacaacag aaaaagaaat gaaacagatc caaaatgaat 2755141 ttaaagagcg tatggatgaa ggagagttat taaattgtat gcgctgcggc ttctgtcttc 2755201 cttcctgtcc gacctatatc gaatcgggat ttcaggaaac acactctccg cgtgggcgca 2755261 tcgccttaat gaaagccgta gccgacggta tgattgaacc ggatgaagat gtcgaacggt 2755321 cgctgtcact ttgcctcggc tgccgcgcct gtgagcctgt atgcccgtct ggcgtgaaat 2755381 acgggcagct gcttgaggaa gccagagata ttatccacca aaataaaaaa cactctcttg 2755441 gtgaacgtgt catgcgaaag acggcttttc acgagctgtt tccgcatcaa aaccgcatgc 2755501 gctcagctgt aagccttatc ggtttgtatc agcgttcagg actgcaaacc gctgtgcgaa 2755561 aatcaggcat gcttcgggtc ctgcctgagc atttgcggac gatggaagct gttcttcctg 2755621 atgttccaaa aagcaaagac atgaaacatc ggccgcgttt cctgccttcc attggcccca 2755681 tgaaaaaacg ggtcgccttt ttttcgggct gcttaatgga tacaatgttt ttaccgacca 2755741 ataacgccac attgaagctt ttacagctgg caggctgcga cattgtcatt ccgcctgaac 2755801 aggcttgctg cggggcgctt catggacaca gcggtgaaaa aaacacaggg aaagagctcg 2755861 cgaaacaaaa tatcgctgct ttcgaagcat tagacgtgga tgcagtcatt acaaacgcag 2755921 gaggatgcgg agcctttctc actgaatatg atcatttgct gaaggatgac cctgagtggt 2755981 cggaacgggc tgccgctttt gttcaaaagc tgaaggattt ttcttctgtt ttggttgaac 2756041 tcgatttcca tcaaatggat ctagcactcg agacgcctca ggtcgttacc taccaagatt 2756101 catgtcatct aagaaatgtg atgcatacgt cactcgagcc ccgccagctt cttaaaagca 2756161 tcaaaggggc ggaattcaaa gaaatggaga aagcagacag ctgctgcggg tcagcgggaa 2756221 tttacaacat cgtcgaagtt gaaatgtcta tgaaaatact ggacagcaaa atggctgccg 2756281 tcaaagcaac cgaagcgatc ctcattgtaa cagcaaatcc tggctgcctg ctgcagatga 2756341 agctcggcat tgaacgcgaa ggactaagcg gtaaagtcag agccgttcac ctggctgatt 2756401 tgctattaga agcagccggg cacaaaacat catgagaaag cccaaaacag acattgtttt 2756461 gggcttttgt gcgttattcc atcggactgc aaatttcgat ataatgtcca tccggatcag 2756521 cgatataggc gaccgtctgc ccccatggtt tcactttcgg ctccccgata atcgatacgc 2756581 cttgttctct catccttttg atgaccgctt ctacattttc agtaacaaac ccgatttcaa 2756641 atgtgtttga agcagatgta tccggaatgt ccagcgccgt gatgtctctg gcgctttccc 2756701 gggtattaag cgccaatatc gtagaccctg tatcaaattc gacatacgtg ccgtgttcag 2756761 cacgaatcgg cagtcctaaa atatcccggt aaaaaatgaa tagcccgctt gctgtccgat 2756821 acgtatagaa taagatattt cattgataga ttcattgcca acccctctca gcattttcaa 2756881 tagtccttct agcccggtat agatgcttcc atccttaagc tcggatcttt ccacatctgc 2756941 gcccattttt tcacagccgc cacgataatg atgaagccta acaccagcat gatgatagat 2757001 aatacgccat tcaatacact atatcctgct gcttcaggat tgagatacac attgcgcacc 2757061 atccaatagc ccgcataatt gacagtgaca tataaatagg caagcgggat aaggcaagtc 2757121 agaatgtacc ggcgtttatc ggcgattttc agcacgatcg tcgctccgat aatcagcccc 2757181 actgaagcca tcagctgatt agaaacgccg aagagcgccc aaatggaacc gatatctcct 2757241 gaatacagca agtaccccca catcaaacag gcaagcgcgc tggcaaatac agagcccgga 2757301 atccagtctg ttttcttcag cggcttatac acctccccga agaagtcctg gatcaaataa 2757361 cgggcgacac gtgtgccggc gtcaatcgct gttaaaataa agaccgcttc aaacataatg 2757421 acaaattgga aaaagtatga ggccaaatgg ctgaaaaacg gcattccggt aaaaatataa 2757481 gtcatcccta ccgcaagcgt gacggctccc cctgttcttc cttctaagtc caaaccgatt 2757541 tccccgctca attcaggcaa atgtacgaca ttcatgccaa gcgtacggaa aacctcaggc 2757601 gtgctgttaa tcgcaaagta atcagcaggc tgtaaagcgg tcgctgcaat cagcgccatg 2757661 ataccgacaa gacactcaac aagcattgcg ccaaacgcaa ccggcttcat atcactccat 2757721 ttattcagca ttttcggtgt cgttcctgag ccgacaaagg catggaaccc agagatcgcc 2757781 ccgcaggcga tggttattga gatgaacggc cagacaggtc ctgccagcac cggccctccg 2757841 ccttttacga attctgtaaa cgcagggaac ggaatggacg gattgacgac aaacacacca 2757901 acaatcaaag cgataaaaac accgattttc ataaagctgc ttaaataatc acgcggagcc 2757961 agaagcagcc aaacgggaag cgcagccgca aaaaacgcat aaacaggaag cgcgattgca 2758021 agcgttttcg tatctagcgt taaaaagtca ccgagcgcgg tagtctgtac ccatggaccg 2758081 ataaagactc ctgccattaa aaagagaaag ccgaccgttg aagcgagctt taaatttccc 2758141 gttttcttat aaaataagcc cacacccatc gcaatcggaa tcgtaatccc caccgcaaat 2758201 gttccccatg gattacgttc aagcgcatgc aagacaacca tcgacaggcc cgccattgtg 2758261 atcgtgatga taaacagcat ggacagtcct gtacaaaatc ctgcaacagg gccaagctca 2758321 tccttcgcca cttccgacag cgattttccg tttttgcgca tcgatgcaaa caacaccaca 2758381 atatcatgga cggctccccc aattaccgcc ccgattaaca gccacaataa tcccggcaaa 2758441 tagccaaact gcgccgccag aattggtccg accagcggcc cggccgctgc gatcgcggca 2758501 aagtggtggc cgaacgaaac ccatttattt gtaggcacat agtctttccc atcctcaagc 2758561 gcatgagcag gtgttggctt gtcatcattc actttgagaa ccttcaccat cataaatgtt 2758621 ccgtataaac gataggcaat agccaaaata cacattgatg ctatcacaat tgtaaccgca 2758681 ttcattttct cccatcccct tttctgtttt tcataaatat atcataattt catggtgaaa 2758741 agcggtcatt ttttcctata caaaaagccg gctggaatgg gccggctcgt ggcagttgaa 2758801 agacaagccg gagagaaatc tccggctttg ctattcttat gactgttttt tcaggcggat 2758861 cacattccag gaaagcggcg tgaaatgagc agttaagccg ttttcgctga cagacgatga 2758921 tccgttggaa tgcggaacga cattttttct gttatgctgg tttgttgctt tgatatcctg 2758981 atgctcaagt acgatgtgct ctgcgatttg gtaggattca aagcctctga gcgaaatctc 2759041 cgtctccatc tgatcctcag ccttgtttac cgcaaaaata gtgagtgttt cttcctcttc 2759101 agagtacaca acagcagcat caacatatgg cacatcagtg aaatcagaac aatcgtactt 2759161 aggagaagaa ataagcggtt tcagtgactc gccccttccg taaacagaag catgcatgta 2759221 tggatagaaa atcggctgtc tccatgcttc tccgcctttt tccgtcatga tcggcgcgat 2759281 gacattaaca agctgtgcaa gacacgcaat tttcacacgg tctgcgtgct gcagcatcgt 2759341 aatgagcaga gagccgacta ataaggcatc ttcaaaattg taaatatcct ctaaaatcgg 2759401 acgcgcagtg atccacggct cgactttttt atcagcctca tttgagtggt accagacgtt 2759461 ccattcatcc agagagagat tgatagtttt cttgctgcgt gtttttgctt ttacatagtc 2759521 acaggtcgca gcgactgatt tgataaaatg atccaaatcc atagaacgtg ccaagtagtt 2759581 tggcagattg ttatcccggt ttccgtagta agtgtgaaga gagatatagt cgacatgctc 2759641 atacgtatgc tcaagcacct tcgcttccca atcgataaag gtcggcatac cgctgtttga 2759701 gctgccgcag gcaacgagtt caattgatgg gtcaacccac ttcatgacct ttgctgtctc 2759761 tgcggcaagc cgtccgtatt catcagctgt tttgtggccg atctgccatg gtccatccat 2759821 ttcgtttcct aagcaccatg ttttgatgcc atacggctgt tcatagccat gcgatcttct 2759881 taaatcactc cagtaagagc ctttcggatg gttgcaatat tcaacgagat tacgggcggc 2759941 atctatgcct cttgtgccaa ggttgacggc catattgacc tcagtgttca ccttttttgc 2760001 ccaagataaa aattcatttg ttcccacttc attggtttct gtcgtttgcc atgccaagtc 2760061 aagccgtctc gggcggtttt cgactggtcc gacaccgtcc tcccagttgt atccggataa 2760121 aaagtttccg cccggatagc ggatgatggg aacctgtaat tctttgatca gcgactggac 2760181 atcttttcta aatccatctt catccgcttc agggtgatca ggctcgtata tgccttcata 2760241 taccgcacga cccatatgtt cgataaacga gccataaatc cgtttatcta cttcaccgat 2760301 tttatattct ttgtctacaa tcattcgcgc ttttttcatc acacgtttcc tccttcatta 2760361 acctttgact ccccctaccg tcaggccgga gataaagtac ttttggaaaa acaagaaaat 2760421 gataatcacc ggcaaaatcg caaatactga gccggatata agcatgtcgt aattatttcc 2760481 ataagggctc agcaagctgg acagccctat tggaagcgta aacatttctt tcgaccgaag 2760541 cacaatcagc ggccacaaga agttgttcca gctgtttaag gactgaagga taatcatcgc 2760601 accgaaagcc ggtttcatca gcggtgccat aatcctgaaa aagatgccga attccgtaca 2760661 gccgtccatc cttgcagagt ccagcagatc tcttggaagg ccaagagcat attgcctgaa 2760721 aaagaaaaca gcaacaggtg aaacgataaa cggcaatatg acacccgtat atgaatcgat 2760781 caagtgcagt ccgacagtaa gtttaaacag aggaagcatc atcacttcca gcggaaccat 2760841 cataataatc agcacaagaa caaagatgat atttctgccc ttaaaatcat aaaccgcaag 2760901 cccgtacccg atcatcgaag aaaaaaacag agtgagcaca gtcgtaaaaa gtccgagtac 2760961 aagactgtta aaaaaccatt tgaaataaat gctgccgcca ttaaacagaa atgtgtagtt 2761021 atcaaaactc atcacttttg gatcaatatc aagattcagc cccacacgca aaagctcaga 2761081 tgacggcttt aatgatccta aaagcaaaca gaaaatcgga aaaagataca ataggctcag 2761141 catcataaaa aacagggtca gcgcaattct ataaacgcta aactgaggac tgtgccgcaa 2761201 catttatccc tcccccttaa acgagcctga cagctttaat gaaatcaggc tgacaacaag 2761261 gatcacaatc aaaagcacaa tgccgatggc cgctccgtat cccatttcat tgtaggcaag 2761321 tccctgctga tacaaatatc cgacaagcgt cagaccaata ttacccgggg aattattctg 2761381 ccaaaggacg tagctttcct caaacatcct gaagccgccg atgatgctga tggtcagcac 2761441 atatacggtt acaggcttga gaaacggcag cgtgatgtgc agaaattttt tcattgtatt 2761501 cgcgccgtct atatcagcgg cttcgtacag ctctttcggc acattttgca aacctgctaa 2761561 aaagtaaagg atgttgattc ccatccatct ccatgaagca agcagcacca tcaaaaacat 2761621 gccggtatgt tcattgttca tccagttctg aggtgaaaag ccgagtttaa gtaggatgga 2761681 attggccaga gacgtttcca tttctccgaa gatcagccga aaaatgatcc ccgcgacaat 2761741 ggttgaggtc aatgccggga taaataatgc tgatttaaat atatttctaa atttgaccag 2761801 ctttgaattc aggaatatgg ccagaagcaa tggaacagga atcagcacga tcagcgtcca 2761861 aaaggtgtat tccagcgtat tccaaagggc ggtatagaac gtcgggttgt ttagcgctgt 2761921 ataattagac aatccgacaa aggacacctc tcccggcaaa attctttgga agctcatgat 2761981 gaagacacta atgatggggt atagaaaaaa tacgagaaag gataaaacga atggcgctgt 2762041 aaacagatag ggcgccgctt tttttgaata aaacagatct cgccagcctg attgtttcgc 2762101 agctgaagga acgggatgaa ccgttcccgt tttcacaggt ttcatgagaa cctccccgct 2762161 ttcacttttt gaatgggatt ctatttctgt ttcagttcac ctgccgctct gtccaaggct 2762221 tgtttaggcg ttttttgctg agatttaagc gcgtcgaaca atacgcttct gttgacaagg 2762281 tctgaagcct tggcaaaatc ctcatgtaaa taaattggat tgatttcatc cttgatatcg 2762341 agcagcacag aaaaaatgcc tgttccgttt tggaagtaat ccgtgtattt gtttttctct 2762401 ttcaattcct tggagctcca aacatcccag cgaagcgggt caaagccgag tacgctccag 2762461 agttttttat ttccttcttc agagcccttc gcaaaggcca aaaactcttt tgctaactca 2762521 acatgcttgg attgcttcgg tacaacagtt gccgtaccgc ccaaacctgc cgagcggtcg 2762581 cccccctctt tccatgccgg gagcggtctg atggcaatct tccctttcag atcaggcata 2762641 taatcgataa atcttcccat ataccaaatc ggcatgagaa ctgaagcagc tcctccttgg 2762701 ttcataaagc cgtagtattc ttcactgtga tgcccgccgc ccggcgcagg aatcatcgtt 2762761 ttatcattga tcatgtcttt taaatattga agtgttttta cgttggtgtc attattgagg 2762821 atcagcttgc cgtttttatc aaaatagcct gagttttgct gtgaaatcat agataagaac 2762881 gttgcggaat catttgtttc caccgttccc atcggcttcc cggtcacttt gcgcactttc 2762941 tgtccggctt tatggtaatc atcccatgtt ttaatatcgt caggattgac gccggctttt 2763001 ttcatcacat ccatgttata aaacatgacc gttgtcccta catgtgtatc gagtccgtaa 2763061 agctttccgt ttttgctgta caatgtcagc cgcgcctcaa cgaatttatc gcgatccttt 2763121 tcaatcagcg gagtcaagtc ggcaagcggt atgtcagagc ccttcaaaaa gtttgaaaaa 2763181 cgggccaatt cgacatctgc aatatcagga acgccttctc ccgctattag ggagatagat 2763241 aagttatcgt gcatttgtcc atatggataa acgaccgtat tcagcttaat tttgcggtca 2763301 ggatattttt tgttccattc cttcaccatt tccacataga actgctcatg aagcccgtta 2763361 aatgtccaaa aggtcagctc agtttcaccc gatttgccgg atgatttttc tgctgaacac 2763421 ccggcaatga ctaatgtcag caacatcatg agcacaagaa aacagacagt catttttttc 2763481 atctgcgtta ccccttccat tcgaggtgcg ggctattcat atagaccatg gttgatcagc 2763541 gttttgtttt cattgatgat tcttaatccg gtgcatcggt ctcttaaggt gtgcgcgtgt 2763601 ctgaaggcat ttttgacgga atcctgcccg acaccgattt cgtcaaaata cgcagggcct 2763661 ccggctgatc tcagccaatc agccagcact tctcctctcg ggagtgtttg ataagccgat 2763721 tggatggctt cccggcggct tggtgaaaat tcgttcagcc cgtcatcctg agcgagcttt 2763781 ctgtatgtgt cagttaataa aacagcggca cagcccacct ttgccccatg aagaatctga 2763841 ggccgttttt tctccattaa ctccatttca atccaatgtg aaatatgatg ctcgccgcct 2763901 gatgccggtc gggaatgatc taatgccagc atgacaagcc ccgatacaag taaagactcc 2763961 atcaaaaccc gtatgccagt ttccgttttc atcgcaatgt cttctgtgtg ttcaatgcag 2764021 gcagcaagcg cctcctgaac gatcttagct cctgcaggcg aataaggctc accggcaaga 2764081 tgccgggata tttcccaatc tgctaaagac gtgattttac cgagcatgtc accaaagcca 2764141 gccgccacca ttgactgcgg tgccgctttt aatagatcca gatcagcgaa cagcgcagat 2764201 ggggccttcg tttgaatggt tgttttcgtg ccgtataaaa taatcggcgc accggctgat 2764261 gtaaaaccgt ctacagatgg agcagtcgga taagaaataa acggcaaatc tctttgaaac 2764321 gccgcaaagc ggacgatatc atgaatcgtg cccgaaccga ctgcgatcat gacatccgtt 2764381 ggttgtttcg tatggatcag cacatgaatg agcgatcgtt catcagctgt cacatctccg 2764441 gcttcatttt ctggaatgat caggcactcg gcctgaaatc cttcttgatt cagtcggttt 2764501 tctaaatcaa ttcctgcaat gcggtgtgta ttcgcgtcgc agacaaggac aatatgttga 2764561 ttgttttttc gttttacata atccaaaagc gaatcagctg cttgcttacc gagaacaatt 2764621 tcttcaactt ttataggcaa cgtcttttct ccggcgtttt caaaagcacg ctgaacgtca 2764681 gctgcgatac gattcatatc agaatcccct cctcagccaa tttggttaca tccttaatag 2764741 aatccagcac ataatccggc gtgtacaaac gctgttcacc ctgtttcgca gaaccagtta 2764801 gcactaaggc gcttttcatg ccataaagct tccccatcgc aatgtcagat tcaatgctgt 2764861 ctcctataat catgcattca tgtgcggaca gccccattgc tgtacaggca gcctccgcca 2764921 tcagccatga cggttttccg acaacaagtt cagtcttcgc ttgtgcagaa gtctcaattg 2764981 ccccgatcat tccggccaca tcaatggcat ttccgtcttc gttcggaaaa gagcggtctt 2765041 tgtttgtagc gataatacga gcgccgccgg cagccgcttg aaaggcttga tttaaatcgt 2765101 cgtacgtgag cgtttcatga agggagatca cgagccaatc cgcttccttc ggttcgctcg 2765161 cgttctgcac accggccagc ctcagctcgt caaccaagcc ttgctcccca agcacccata 2765221 cctttgaaaa acgataatgt tttttcagaa aagccgctgt cacgcttgat gacagaacaa 2765281 tgtcgtttac gtccgtttca atccccgcgc caagaagttt ttttctgcac atggcacggg 2765341 agatattccc ccggttgctt aaaaagacga ttttctttcc cattctccta agcgttttga 2765401 tcgcttctct tgctccttcg atcaactcat ttcctctgaa tacagtaccg tccaagtcaa 2765461 tcagaatgcc agccggtgac acaggcgtat catgactggc cataatacgc atttgctccg 2765521 tgttttcgat aaaaatgctt ttcatgcagg actgtattga ttggggttac atccttgttc 2765581 agcataatgg agtgataggc catttcggca accgtttcta atacaactgc gttatgaatg 2765641 gcatttaagg cgtcagtgcc ccagcagaac ggtccgtgat tattcacgag cacacccggc 2765701 acctgttcgt aattatgatg ctgaaaggtt tccgctatga cttttcctgt attcagttcg 2765761 tagtcatgaa tgatttcttc atcgtacatt tctcgagtac atggaatcgc actgtcaaaa 2765821 taatcagcat gggtcgtgcc taacggaggg atgtctctgc ccgattgcgc ccagcttgtc 2765881 gcccattgag aatgggtatg gacaattccc ccgatattcg gaaaggcttt atatagataa 2765941 acatgggtag gtgtatctga agaaggttta agcgagcctt cgacgacctc tccatcaagg 2766001 ttcaaaacaa ccaagtcatc ggctgtcagg tcgctgtatt cgactccgct aggtttgatg 2766061 acaattcttt ctttttcacg gtcaatgccg ctgacatttc cccacgtaaa ggttaccagc 2766121 tgatgctctt gaagcttcag gttggcagcc agcacttctt tttttaatgt ttcaagcatg 2766181 ctccatcacc ctttatcaat tctttttggc ggcagatgaa aattgaagat ttttgatcgt 2766241 tttcagacgc ttcatgacat ggttttcttt tccgaaataa tgaaccagct ctttatattc 2766301 agcgtacaat ttttcataaa ccgcggcgtt ttcggcattt ggcgtataag ttatatcttt 2766361 cagttttccc atgttcgccg ctgccttttt gatatcatcg tagccgcctt tttctttgcc 2766421 tgctgcaagc gcgccgaaaa tggcagatcc taaggctggg gcttgcggtg aaccagagat 2766481 tttaatgtcc atgtttgtca catccgcata aatctgcatg acaaacgggt ttttctcagc 2766541 tattccgccg gctgcgaaca gttcctcaat cggaacaccg ctttctttga atgtttcgat 2766601 aatcatccgg gttccgtaag ctgtcgcttc aactaacgct ctataaatct cttcaggctt 2766661 cgtcagcagt gtcatgccaa gcagcatccc tgttaaatct gcatcaacaa gagttgaacg 2766721 gtttccattc caccaatcta aagcaagcaa gccgctttca ccaggcgctt gatggtttgc 2766781 tttctcactc agcagctcat gaacgccaat gtttttttcc tttgcttcct cttgataagc 2766841 tggcgggaca catgttttca caaaccagtc aaaatgatcg ccgacacagg actgcccggc 2766901 ttcatatccc gcatagcccg ggagaattcc gttgtccaca acgccgcaca ttcctggaac 2766961 gatatgcacc tcttcaccaa gtagaacatg gcacgtcgag gttcccataa tcatcagcat 2767021 tttccctggc tctgtaatgc cgaccgccgg taccgaaaca tgagcgtcca cattggcaac 2767081 cgcaacagcc gttcccggga gaagccctgt cagctttgcc attttttcag tcagactgcc 2767141 ggctttttct cctactgaat gaatagaacc tgacaatttg tcctttgtaa tcgttttcat 2767201 tgaaggattt aatttctcaa agaaatcatc tgacggatac cccgcttttt cactccacat 2767261 cgctttatac cctgcggtac aattgcttcg cttgagcgag ccgcacagct ggtacacgat 2767321 ccagtccgca gcctcgatga tccggtcagc cgcttcataa atgtgaggcg cttcctcggc 2767381 aatttgcatg acctttggaa tcatccattc tgatgaaatt tttcctccgt accgctgtaa 2767441 aaaagcctct ccttcttctt ccgcgatttg attgagccga tcagcatgtt tttgggccgc 2767501 atgatgcttc cagagcttca catagctgtg cggctcctct tcatattcag gcagcatgca 2767561 taacggctgc ccgctgctgt caataggaag gatcgtacat gccgtgaaat caattccaat 2767621 cccgataatg tctttcgggt caacgcccgt ctgttcgagt aaagacggaa tggttgtttc 2767681 caagacttcg aggtaatcag cagggtgctg cagcgcccag tcacgcggca gcttttgacc 2767741 cgtttttgga aggacggtat caatgacagc atgcctgtat tcttttacag cagccgcaag 2767801 ttcctcccct gtttggacat gaacgagcac tgctcttcct gataaagttc caaaatcaac 2767861 ccctattgtg taagccatgt gacatccccc tctacttttg aagccggtaa agcgcctcgt 2767921 tccattttaa ctcgtgtttc agtttatgaa ttgtcgtatc acgggaaatg agaacacttt 2767981 cgattcccgc catttccgcc caatcaagca tttgctccgc tgtcagttca taagacaggc 2768041 aggtatggtg tgcaccgccg gctaaaatcc atgcctccgc tgctgttttc aatgacggct 2768101 ccggcttcca gagaacacgg gcaaccggta aattcggcat gtctttttca atttcctggc 2768161 cgttgacttc attcagcaca aggcggaaac gcccgccaat atcaacaatg ctagcttgaa 2768221 tggcagaacc gctgatgccg ttaaatacca aacgcgcagg gtcctctttg ccgccaatcg 2768281 aaagcgaatg aacctcgatt ttcggctgat ccaaagcgac agtcggacac acttcaagca 2768341 tgtgagagcc cagaatcatt tcatttcccg gttcaaaatg gtacgtgtaa tcttccatga 2768401 aggaagttct ttttccttta gccatgattt tcatcatccg tacaagggcc gctgtcttcc 2768461 aatctccttc accggcaaac ccatagcctt tctccatcag gcgctgaacg gcaagtcccg 2768521 gcagctgttt cattccgtgc agcacttcaa acgatgtcgt aaacgctgtg tatccgcctt 2768581 gctcaagaaa agcggttaat ccaagttcaa ttttcgcctg ttctttaatg gacgctacct 2768641 ttgcttcgtc acgttttgtt tcctcactga tcacatatag tctgtcatac tcggcataaa 2768701 gcgtgtcaac ctcgtcgtcc gtaatgcgat ccatcacttc aacgagatcc ccgatgccat 2768761 atccgtcaac ctgccagcca aattgaatat gcgctcccac cttgtctccg tccgttaccg 2768821 cgacatgacg catgttatct ccaaatctgg caaccttaat atgtctgctt tcatttaatg 2768881 cagccgccgt atccatccac tgggacattt cttttttcac ttcttcatca tcccaatagc 2768941 cggcaatgac ttttcggcta agccccattc tcgagttgat gtaaccgtac tctcgatcgc 2769001 catgcgcgga ttggttgctg ttcataaaat ccatgtcaat cgtaccccac gggatatcgc 2769061 gattatattg ggtatgcaaa tgcataagcg gtttttgata agaggaaagg ccttctatcc 2769121 acatttttgc aggggaaaat gtgtgcatcc atgtaatgat gccagcacat gtctcactgt 2769181 actccgcttc tcttaacagc tctctaatgg tttccggtga agtgacgacg ggcttatgag 2769241 tgattttata tctggaagaa atcccgctga gcccctcaca aatgctttta gcatgctgat 2769301 ctacgagttc cagcgtctct tccccgtata ggtgctggct tcctgtcaca aaccagaatt 2769361 cataatcctt tgtctgaagc atgtaaactg cccctttctc ataaaataaa acgctttcaa 2769421 atacaaaaga tacgtactaa tgatagaaaa taaacctata aataaatatt tgtacgaaca 2769481 attttattat agtaattgac tattatactg tcaatctttt cttttaaaaa aagccggggg 2769541 cagagcccgg ctttttaatt caataggacg gccagcccga gctccaattc aaatcattga 2769601 tgagaagctt tggaatgccg ttgtcattgg catcataggc atggcgaaca agaatgtttc 2769661 cgttcacaat atcctggcct ccaggtcctt tccattggtc attgcccgaa tccaaaatgg 2769721 tgcctccgcc ttcaagcatg ctttttccgc ttttatcaag ataagggcct gtaatgcttt 2769781 tggatcttcc gtaagcaatt ttgtacgtac tgtttacccc gtcacagcat ttatcaaatg 2769841 aaaccattaa atagtaatat ccattttgat acgtaagagt aggagcttct aaggcacctc 2769901 cattattcgg tctagctgca atcgaataga gcgagcctgt aggcttcatt gtactcttat 2769961 cgagcttagt cagcttaatg ccgctccaaa acgagccgaa tgcaagccac gggttgccat 2770021 ccttatcgaa tgtcagctcc ggatcaatgg cgttataatt atttgagctt gtcgaacgga 2770081 tcaccaagcc ctcgtccttc cagccccccg aactgatgct tgttgaagat gccaggccaa 2770141 tggcagatgt attgcttcca aaagaagaaa cggaataata tagccagtac ttgccgttat 2770201 agtattggat gtccggcgcc cactggtttt ggccataatt cggcacataa ttggaccacc 2770261 acgatagcgg tgtagtgaaa atggattttt gtacggtcca atttttagcg tctgaagact 2770321 tcaaaacccg cagtccccgt tcttcagtaa gccctgttcc gagcgcatac catgagctcc 2770381 cctctttaat catagtcggg tcatgaagca gctcattgga tgcaccccaa aacgctgcct 2770441 ctgcgggagc agcagaagtg aatatcaaac ctgcagccag agctgcactc gaaaagtgta 2770501 agaagcgttt ccatgttttt ttctttttca attttgttca acctccttta ttttagaaag 2770561 cgcttacaaa ttagattatt tatcctccct tcctgtcaaa tcgactgcgt atcgtatatc 2770621 gtcatgttca ggaaattttc ggtatcccct ttattgtagt cactatgctg taatttgtac 2770681 agacaaaaaa atagaatcca cctcaatagg cggattcttc cgtatcttta ttggtacgta 2770741 atttcgtcaa ccgtttttcg gtctaacttc ttaatgactt ctgtaattaa ctttaccgcg 2770801 ttttcataat catcacgatg cagcatggcc gcgtgcgtat gaatgtagcg ggttgcaatg 2770861 gtaatggaca gcgcaggaac gccatttgcc gtcaaatgga tggcacccga atcagttccg 2770921 ccgccggcaa tggcatcaaa ttggtacgga atgccggctt cctccgcagt ggctacaact 2770981 gcatcgcgca aacctttgtg agagaccatg gatgcatcgt aaacgataat ctgcgggcct 2771041 ttgcccattt tgctctgcgc ttccttctcg gaaatgccag gcgtgtctcc tgctatccct 2771101 acatcaacac caaacgcaat atcaggctga atggtgtgtg cagccgtttt cgctcccctc 2771161 agcccgactt cctcctgcac ggttccgacg ccatacacta tatttggatg atctgtgttt 2771221 tgtaagtttc ttaacacatc aatagcaatc gcacagccga tgcggttgtc ccaggccttt 2771281 gcgagtagga atttttcatt gttcatgacc gtaaattcaa aatgcggaac gatcatatct 2771341 cccggaagta caccccactc caaggcttct tcccggcttg aagctccaat atcaataaac 2771401 atgtctttta tttccactga tttttttctt gcttcaggag acaaaatatg aggcggctta 2771461 gatccgataa cccctgtgat ttctcctttt tttgtgacaa tggtgacgcg ctgagcaagc 2771521 ataacctgag cccaccagcc gccaacggtt tgaaaacgga taaagccttt atctgtgatt 2771581 tgtgtcacca taaagccgac ttcatccaaa tgtccggcga tcataatttt cgggccgttt 2771641 tctgcaccag ttttttttgc aattaaactg cccaggcgat ctgttgtcac ctcatcagca 2771701 aatggttcta tgtatgattt catcacttgc cttacttctc tttcattgcc cggtatgcct 2771761 tttgcatctg ttaaatcttt cagcatggtc aatgtttcat ctaattttgc catgttccaa 2771821 accctccttc atcagtcctg cattcttatt atacaaaaca tggcgctaac catacgacta 2771881 tttcacttga aaatcgggta tatgttttta cagctttctt ttagaaaaag tgaaaccttt 2771941 ttctatgctt ttcgtattac atcagatcat caccataagg gaggtgcctt cacacaatgt 2772001 ttgtcatggt tctaaggatt attttgcttg cactttttgc ttattgtatt tatgccgtgg 2772061 tcaaatatgt cgcgaatcct aagagaaggc ttaagctggc ccaatcaaaa gaacattttt 2772121 atattattga tgaacaaaac aatacccgga agaattttca gctgacgtat aaaggcgtgc 2772181 tttttgaggg agaaaagcat attccttcca aggatcatcc gctgtttatt cacacgatct 2772241 ttgtctggac agaatctcct gagaagctga aacatttctc tgcaaaagat tttgagaaca 2772301 ttgaagaaaa agtgctggaa cgatatccaa attgtaagat tgactgggac cagcccatta 2772361 aactcgcaaa aaaagcagaa gagcgttaaa cgcttttctg ctttttataa atcaaacggg 2772421 ctgtagtaaa tagcgatgag aatcgcttct attaccagaa gaagcggtac tccgtactta 2772481 aaagaagcgt gtttcgtttt atgtctgaag gtttgcatgc caagccagac accgagcgct 2772541 ccaaacacga tggctatcag ccacagccgg tcttcagaaa ttctccactt gtgctgctgc 2772601 gctttgcgtt tgtcaatgcc catcacccaa aaaccgcaca gattaatcaa caccaaataa 2772661 gcagcaataa tcatgttgcc tcatccttta tatagaaaaa gccgctctgc tggagagcgg 2772721 ctctatatga ttacttgttt aattgagctt tagcagcatc agcaagctga ttgaatgcag 2772781 taagatcgtt tacagcaaga tcagcaagca ttttacggtt tacttcgata ccagaaagct 2772841 taagaccgtg cattaaacgg ctgtaagaaa ggccgttcat gcgagcagct gcgttgatac 2772901 gagtgatcca aagtttacgg aaatcacgtt ttttctgacg acggtcacgg aaagcatagt 2772961 ttccagattt catgacctgc tggttagcta ctttgtataa tgtatgtttt gaaccgaaat 2773021 aaccttttgc taatttaaga acctttttac gacgcttacg tgtaacagtt ccgcctttta 2773081 ctcttggcat tgaatttccc tcctaattgt tccttatccg attacttgat gttagcaagc 2773141 atttgtttga tacgtttgaa gtctcctgcg cttacaacag cactcttgcg aagcttacgc 2773201 ttttgctttt gagatttgtt ggcgaataag tgacttgtgt acgcgtgaga acgttttaac 2773261 ttcccagaac ctgtcttttt aaaacgttta gcagatccgc ggtgagtttt catttttggc 2773321 atgggatttc ctccttattg cttttcgttt ttcggtgcga gcattaagaa catgctgcgg 2773381 ccgtccattt ttggttttgt ttcgactgtc gcaacctcag cacatgcttc ggagaaacgg 2773441 tctaatacac gctgaccgat ttctttatga gtgattgcgc gtcctttaaa gcggatagaa 2773501 gctttcactt tatcgccttt ttcaaggaat ttaatcgcat tgcgcaattt cgtgttaaag 2773561 tcatgctcat cgattgtcgg acttaaccga acttctttta agttaatgat tttttgattc 2773621 ttgcgtgctt ctttttcctt tttctgctgc tcaaatcgga acttaccgta gtccatgatt 2773681 cggcagacag gcggttttgc attcgctgca actaacacaa ggtcaagatt tgcgcggccg 2773741 gcgatttcaa gtgcttcctg acgggacttg attccaagct ggtcgccatt ttgtccgatt 2773801 aaacggacct cacgtgcacg gataccctca ttaaccaatt gatctttgct aataatgagc 2773861 cacctccata gtttcttcga attgattcac aactcatttt gaatgcattt tgcaggcaaa 2773921 caaaaagtgt gggcattata aaacacccac actacgaaca tctgtatcaa taaaaatgta 2773981 cggtcaacct gccaactaca tgcatgtgtc aatcaggtga gaagcgggtg cttctgcttg 2774041 tgatttatat tcaattcaat aactattcta cacaataccg gatctttagt caaggacgac 2774101 ttatccggaa caacttttac attgtaacat gggttttcta tgagcgcaag agagaaaaag 2774161 aaaatctttc atccccaccc agaatacaaa gaaccaacaa ttccccctta ttacgcaatt 2774221 tacaacaaaa ccaccgacag gaagaaatgt aaaacaaagt taatctctga ccgatataag 2774281 gagcagaagg gagcctgaca catgaacaaa ctgatacagc ttgctttatt tttcacattg 2774341 atgttaaccg gttgctcgaa tagcagcaca tcttccgaat caaaagtcga aaccactgtt 2774401 aagacaacgg cagcatttcc tcaaaaggag ctggagaaag agctaaaaaa actaaaaccc 2774461 gtttcattgg acatgaagtt cgagagtcca ctcgctaccg agttaggaaa gcggaaggca 2774521 aaagaggaag ctgaaaagca aagacaaatc gccgctgaga aaaagcttga aaaagagcgg 2774581 gaggcgaaac gaaagaaaca gcaggaggaa aaagcggaga gacagcgatt agcagagcag 2774641 caggctgcag agagacagcg attagccgaa gcggaaagac aagctgaact tgaaagacag 2774701 cggcaggcag caatccaaaa agagcagaaa gcgaacgctg agaaaaagcg gcaatcgcag 2774761 gcacaacggc agcagactga ggcaccctca tctaatagtc aagatccacc atcttcctcg 2774821 agtcagacag ataaaaccat tcaacagcca gcttcagagc ttcctgatga cgatggttat 2774881 ggttatgaag aacgaaaaaa gtggcatgac gatcaagtag aatggggcat taaacaaggg 2774941 tatatcgatc ccgaagacgc accataaaat aaaaaaagcc aaggcattca gccttggctt 2775001 atcctccgat cagctgcacg aacacaggga tgaccagaac cgttaccact cctactacga 2775061 caacagcaat acttgccatc gcagcttcaa cttctcccat ctcaatcccg accgctacac 2775121 caagtgcatg tccggatgtt ccaagagcca atcctttaga aatcggattt ttcactttaa 2775181 acaccttcaa gaacaatgct ccgagcgcat atacgatgac agcgttaaag atgaccgcaa 2775241 aggctgtgat gtcgctgatg cccccgatgc cttttgataa aggaagcgca attgccgttg 2775301 tagccgcctg cggaagcatg cttttcatta cggccgaatc gagatgaatg cctttagcga 2775361 gcagataaac aatcgtgaca gagcagatag agccggcaat aatggaggcc atgatttgcc 2775421 accagtactt tttaagctta tctctttgtt tgtacaaagg aattgcaaat gcgatcgttg 2775481 ccggttcaag aaaaaactta atgatctctc ccccgttatt ataatccgcg taggaaaaac 2775541 cgccgatttt taaaaatgcg atccccagca ccatggcaac aaacaaagga gtgaaaagga 2775601 agaagccttt cgttttctta aataaaaagg tgccgatgcc gaatgcagca agtgatacga 2775661 caatcccaaa ataaggactc attgtgcttt ccatgtgaag aacctcctgt ttcccttaat 2775721 ggtgaacgag ttcgttattg ttctgcgggc tttgcactgt ttttgttttc atgtccgctt 2775781 cggttttgcg ttttccgctc agcgacagaa tcagctgaga aaacaatccc gtagccccca 2775841 gcaaaataat cgttgcgagc agaatgacaa gaacaatttg caggccgtat tgctgcatca 2775901 caccaagcga attcataaca gatatacctg atggaacaaa taaaaatccg atcagagagg 2775961 ttaaagacgt tccgagcgtc tccacttgtt ccagtttaat gactttcaaa cataatagga 2776021 gaaataataa gaccaaccct acaaccgatg ccgggatagg tattgggaca atagcggcaa 2776081 tcatatttga aaccagcata atgacggcaa aaataaatgc ttgtgttaaa aacccgtaca 2776141 cttttttagc actcattttc ttcacctctt tctctttggt accctcatta taaataagaa 2776201 ttccctgtta taaagcgctt acaagataac atgccgtata gcgggtctga gttgcagaat 2776261 caaatggctg aaatgcaaaa agccgcccat caaatatgga gcagcttttt caattccttc 2776321 gcatatgtcc ggctgaccgg tattttcgat ccgtctttca tgatcagatt atacgttgaa 2776381 ttaaaccatg gctgaatttc tttaatatat tcagtattca cgacaaagct ccgatggacg 2776441 cggataaaat cagaatccgg cagctttttc tcaatcacaa cgagtgtatc gctgaccgta 2776501 taagaatgat cgaaggtttt tacattgaca tgaccatctt ctgttccggc atagataatg 2776561 tccttcgtat ccacaatcac aatcgattcc cccacagata gcgcgagctt gtgctggccg 2776621 gcatggctgt tttgctctgt ttctacaata tcccgattga cttttttata ttttttcagc 2776681 gtttgctgaa ttctttcttc atcgaaaggc ttggttaaat aatcaagagc gtccacctca 2776741 aacgctttga gcgcatactg gtcatacgct gtcgcaaaca caatagcagg aggatgcttc 2776801 attttcttca atcgctttgc gatatcaaaa ccgttttctc cggataaatc aacgtctaaa 2776861 aacagcaaat caggtttttg atccatcatt tggtcaaaag cggattcgat attttccgct 2776921 tcattgattt ccatttcatc attggtccgc ttaagcaagt aagccagttc atcccttgcc 2776981 agcatctcat catcaactat taacaccctg agcatgttct tctccctctt tcatctgttg 2777041 cattggcact tgaaaggaaa cctctgtccc tttatgaacc tcactgctga tatgcagtgc 2777101 agcctgctgt ccgaataaac cgatcagccg ctgatttagg ttataaagcg ctgtaccggt 2777161 tccctcctta gacggaaacg gtttcttccc cagttccggc aagacgtccg gcggaattcc 2777221 gcgtccgtta tccgccacct tcatatagac ggatgcatca tcagataaga cacagactgt 2777281 aaccttgcat atgtcttgtt ttttcggaaa cgcgtgccga agcgcgttct cgacaagcac 2777341 ctgcaaaaca aacggaggga tttcaatctg ctccagtctg ctgtcgatat taagctcaat 2777401 tttatatttc ccgggaaaac gcgcctgttc taatgacaaa taggcgttaa gatggttcag 2777461 ctcctttgag agcggaatca gcagctgtct cgctccttga aggtttgaac gaaaataaac 2777521 actgagctgc aataggagct tacgggtttt ttcaacatct gtacggcata acgcagaaat 2777581 cgtgttgatc gcattaaata aaaaatgcgg attcacctgt gcttgaagcg ctttaatttc 2777641 agcatccttg agaagtttgc tttgcagctc tgcttcccca agctcaagct gtgtcgaaaa 2777701 cagcatggcc agcccctcgg caagttcctc ctctacctga ctcaggcctg ccgggctttt 2777761 aaagtacatt tttaaggtgc cgattgtatt gccgttcgat gtcagcggta ggacaattgc 2777821 agcgtgcaaa gggcattcag catgcgtgca ttcaatctct tcctgcgaaa tcgccttcat 2777881 aatatgccct gttttaatca cctttttgga caggccggtg atcaagcttt tcgatgggat 2777941 gtggtgatcc attcccgcac cgacatgcgc aaggatcttt tctttgtcag tgagagacac 2778001 cgcatctgtt cctgtcagct tatggataat agccgctaca cttttacagg agttttcatt 2778061 taatccttgg cggaaaaatg gaagtgtctg atcagcaatc gtaagcactc gatgcgtttc 2778121 gagagccctt gcctgttctt ccttgcgaat gatcgcttga ataatagaca gaaaaataaa 2778181 actgcctgtt ccattgatga gtatcatcgg aattccgatc atgctgacaa gctcccaagc 2778241 gtcactgaac ggctttgcca tcagcaaaat aatgatcatt tgcagtgact ccatgccgat 2778301 tcccacaaga gcggcgatgc gcggtgtcgg cattcgatat cgcttcgtaa aatacctgcc 2778361 gatcaagcct gcaagaacac ccgctaaaat agatgagacg gcacagctta aggccgtgct 2778421 gccaccgagt gaaaaacgat gcaggcccgc aagtatgccg atcccagccc ctacaaaagg 2778481 acctccgaga aggcccccga tttccacgcc caaaatacgg gtattcgcga tagagcccga 2778541 tggatctatc gtaaacaccc agtcattgtt tacaatcata tttctttgaa tttcgatgcc 2778601 tgtataattg ctgatgatgc tgaaaagaga aaaaatagaa attaaaatcg cttttccttt 2778661 atagccgtcc tgattctgaa gagcttgtct gaaaagtttc gtatgggcga gaatgaaccc 2778721 taatataaca ataatcccca ctctctccag catcataatc attaaatgaa tcattcatgt 2778781 cacctgttct ttccgttttc attctagcat gttttcgttt tgcggctgac tgttttttta 2778841 aaatcgtctg aaaacatatt tcacaaggct tttatctatt gtaaaataaa acatgagcct 2778901 tttggcagaa agatttgaat ctgaagcaga ggagaagatc atgaaagccg tattttttga 2778961 tttagatgat acactacttt gggacgaaaa aagcgtcaga acaacatttg cagaaacttg 2779021 cttacaggcg gagaaaaaat atggccttgc ccctgaggaa ttcgaagcag ctgttcgcga 2779081 agcggcgaga gaattgtaca tgtcatatga gacgtatcca tatacagtga tgatcggcat 2779141 taacccgttt gaaggactgt ggtccaattt ctcagagcca atcagtgaag gctttcaaaa 2779201 gctgaacaag attgtgccgg agtacagaag aaatgcatgg accaacggac tgaaagcgct 2779261 tgggatcgat gatcctgcat atggcgaata cttgggagag ttttttgcgg cagagcgcag 2779321 aaagcgcccg tttgtatatg atgaaacttt tgctgtactc gatcaattaa aaggcaagta 2779381 tgaattattg cttttgacaa atggcgatcc tagtctgcaa aaggagaagc ttgccggcgt 2779441 gcctgagctc gctccttact tcaatgaaat cgtcatctcg ggcgcattcg gcaagggcaa 2779501 gccggatgtt tcaatttttg aacactgcct taagctgatg aatattgaaa aagacgatgc 2779561 catcatggtc ggcgataatt tgaatactga tattttaggc gcttcaagag ccggaatcaa 2779621 aaccgtttgg atcaaccgga ctgataagaa aaacgaaact gacgtaaagc ctgattacat 2779681 catcagcagc cttcatgatt tgtttcctat attagagaaa taaaaaaagc atgatctctt 2779741 caatgagatc atgctttttt attttatttt ttcgcttcag ctactgcctt tttcacaaac 2779801 tcatcaagtg aaatggtttc agagttctgt tctccgtatt tacgcacgtt taccgctccg 2779861 ttttctgctt cttggtcacc gaccaccagc atgtacggga ttttttgcat ttgcgcttca 2779921 cggattttgt agccgatttt ttcatcgcgg ctgtcgactt caacacgcag gccttcacat 2779981 tgcaggcgtt cctgcacttt tttcgcgtag tctaaatgca cagccggaga aaccgggatg 2780041 acttggaact gaaccggtgc aagccatgtc ggcagcgcgc ctttgtgttc ttcgattaag 2780101 aaagcaacaa agcgttccat tgttgaaacg acacctctgt gaatgacaac cggacggtgc 2780161 tgcttgccgt cctcaccgat gtatgtcagg tcgaaacgtt ccggcaataa gaaatcaagc 2780221 tgaaccgtag acagtgtttc ttcttttccg atcgcagttt tcacctgaac atcaagttta 2780281 ggtccgtaga atgccgcttc accttctgct tcgtaatagt cgtggccgat ttcatccatt 2780341 gcctctttca gcatggattg cgctttgttc cacatttcat cgtcatcaaa atatttctct 2780401 gtatcttccg gatcgcggta agacagacgg aatgtgtaat cacttaaacc gaagtcttca 2780461 taaacatcct ggattaaacg gactgtacgg ataaactcat ccttaatttg atccgggcgc 2780521 acaaagatgt gtgcatcatt taacgtcatt ccgcgtaccc gttgaagtcc tgacagcgca 2780581 cctgacattt catagcggtg catcgttcca agctctgcaa tacgaatcgg aagctcgcgg 2780641 taactgtgaa tgtcttgttt gtaaatcatc atatggtgcg gacagttcat cggacgcaat 2780701 acaagtgttt cattgtccat ttccatcgga gggaacatgc cttcctgata atgatcccag 2780761 tgtcctgatg tttcatacag ctctttgctg cctagcacag gtgtgtatac gtgctcatag 2780821 ccgaggctga tttctttatc gacaatgtag cgctcgatga cgcggcggat tgttgcgcct 2780881 tttggcagcc aaagcggcag gccttgtccg actttttgag agttcgcgaa cagctttaat 2780941 tctttgccaa gctttctgtg gtcgcgttct ttcgcttctt ctagcatacg aagatgctct 2781001 tcaagatcag cttttttgaa gaaagctgta ccatatacgc gctgaagcat ttggtttttg 2781061 ctgtcaccgc gccagtatgc gcctgcaagg cttaacagct taaattcttt gatttttccg 2781121 gttgaaggaa catggacgcc gcggcacagg tcaaagaatt cgccttgctc atagatcgaa 2781181 acggtttctc cttcaggaat cgcatccaat agttcaagct tcaggtcgtc gccgatttcc 2781241 gcaaaacggg ctttcgcttc ttcacggctg acttcttttc gaacgatcgg aaggttcgca 2781301 ttaacgattt ttttcatttc tttctcgatt ttcggcagat cctccggtgt aatcgcttcg 2781361 tccatttcta catcgtagta aaaaccgttt tcgataaccg gaccgacgcc gaatttaaca 2781421 tccttgtaga tgcgtttaat cgcttgagcc agcaagtgag ccgcactgtg gcgcataatt 2781481 tgaagacctt cttctgagcc ttctgtaatg atttccactg taccgtcttc attgatcggc 2781541 gttctcaaat cgatttcttt tccgttcagt tttccggcta atgacttttt ctttaatccc 2781601 ggactgatgg atgccgcgat atcttctgtt gttgttcctt tcgcaaactc cttgactgct 2781661 ccatcaggaa atgtgatttt taccatatct gacatctttg tcactccttt ttttgcatat 2781721 aaaaaccccg ccccctatga aagggacgag gttgaataaa cggaatcgtg gttccaccct 2781781 tttttccgca aagccaatac acggcacctg cggctctaag ctctgtaacg ggagttcccg 2781841 tcagccatta ctgttccttt tcaagaggtt cacagctgaa gttcaaaggc ggtaaagcga 2781901 atggtcctta gctgggaagc ttgcagccag ggcttccctc tctttgagcc ggtatcattc 2781961 cttcgtgtcc ttatcaatac gtgtgtcttt cttaatctcc tatgtattat aaattgttca 2782021 atccaaaaaa tcaacacgat cgcgtttcct tttttttaaa ccgacagcct taaatagaca 2782081 ggctgccggc cctcatcctt ccgagtgctt caccggtatt tctgcatctg taaaagcatg 2782141 cagcgggagc atttccactc tctcttgaaa tacgttttga atggtccttg ccatcatgtg 2782201 ctcgggctgg tcggtataaa gcacgacttc atcaggcgca atggaaatca gcggcgcgag 2782261 caaatgagaa tcaatataca taggatgatc ccggacaaat cttctgtcta tgtatttcat 2782321 tttttcccgt tccggcacat agcgcagctc ccataatgta aaggaaccat catggacaat 2782381 atgcactttt ttgattcgcg gctgtttggc gtccacatag tctctgagtg tttgaataaa 2782441 gttttgatat tcctgttcca tcttatattc atcaatcgct gcttctgtaa tatctctcag 2782501 ctgcttatag tatgatccaa gtcggaaggt ctgaaaggag cgaatgtaaa atactccttc 2782561 ctctaaacag atcgtttgga gttcatccaa aattgattgt ttccgtgaaa gcttcagcgg 2782621 ctcaaacgga agatcgtctg cttcaccttc aataatactg tgtgcgagct gaaggatttg 2782681 ctgctgttca tcctggtccg tgaaacaata cgtttcctca atcaatgaca gcatatgctc 2782741 gtcttctttg cattccaaaa aaaatttgac cagaatcggc tccataaaac gctgaatagg 2782801 aaaagccgga ttcgcttttt caatcccgat ttttcgtatg ccttcacgga caatgatatt 2782861 gttccgatcg tccgaatgct gaatgagatg taaaaaagcg gctgcatcat ggtcatcttc 2782921 aaagattatt tcaagcatgt ttgtcccccc ttacggcatc tgttacaagt atatggggga 2782981 tgtttttaaa atagacgtaa aggtcattgg caaatcttaa tttgattctt ggaacaagtt 2783041 ttgcattttc tttctgaaga tgaacggcaa tgagataaac acgatataca aagcgagcac 2783101 cataaagaaa gcgggcagat tgccagccaa aaagctcgca cccagcacat taagcgcaat 2783161 cgtcccaggg atgattccca cagccgttgc ggcaaaatac ggcagcgctt tgacattgga 2783221 aaggcctgcc gcatagctga cgaaatcaaa attgatcggc aggattctca aaagaaagat 2783281 atagaaaaat ccgttatcct ccatttgctt ctgtatggct tcaagccttt cgtaatgccc 2783341 gttctttttc gccgaaaaca aaccagccgc aaaaaacgaa acagctgaag cgcacatcga 2783401 accgaataac gtataaagcg tgccgagaag cgggccaaac gcaagtccgc cagctattga 2783461 aataacagac accggaaata aaacaagtgg cctgacgatg gatatcccga taaacatcag 2783521 aggtgcaaag actccgaacg acaataccca taccctgatt tctttcggcg atacattcaa 2783581 atacgtttta tttccccaat agagtaaacc agcacctgca agcactgcca gccatttgac 2783641 agccgttttt cgtttcatac cctcagttcc ttcccctttg aaccacagca attatggatg 2783701 tcggcggttt tctccgtcaa ggcggatcgg agcagccaaa tataatatcc gctccattaa 2783761 tcttgcagct tttacttctt ctttttctcc cctctgcgaa tacgtaaaat gatgcttcag 2783821 ctcgtcaggt gagaaattag aagaaaagaa cgttggcagc tgctgggaca ttctgtgctg 2783881 aagcaccgtt ccgatgacct catcccttac ccagcttgtc attgattctg ctccgatgtc 2783941 atcaagcatt aatacgggtg tggtctttac catattgagc ttctcttcca atgtctggtc 2784001 ttgcagcgaa ttcttaagct ctctcacaaa ttcaggcaca taaacaatca tggaggaata 2784061 ctctttttcc gccagctcat tggcaattgc agcgagcata aacgtttttc ctaccccaaa 2784121 tttcccgtat aaatataatc ctttcccttt tcccgtctca ttatagcttt tcaggaagtc 2784181 tgtaacatgc tgaaacatcg cgagtctgct tgggtcactg atatcaactt gctggaacgt 2784241 cgctccaaga agatcctgct ggatatacat gcttttcata agagactgtt gtttcttctg 2784301 ctggtcgagc ttccgtttga ctggacattc gtaatactcg atatcaatag acctcccatt 2784361 gacaacaagc ttcggatggt agccctccaa caaattgttg cagttttcat cttccgaaca 2784421 ataggagcaa ttcttgcttt gttcgatata ttcataaagc ttatttaagc tcttttcgat 2784481 cattttttgg tcaatcactt cttcgttttc cttcaaaaat gcttgaacat cttgatcttt 2784541 catgactttt tccttcattt gttcaagacg tttttggaaa tccggcctgc cggttacgcc 2784601 ctgcagggaa cggccgattg gttccatcta ttccttcacc ccgcatctct gtctttaata 2784661 ggcagagtat tttttcagtt tttgcatttc ttccatcatc tttttcttct gttcttccaa 2784721 atcctgcgga tgcagcttct gctgtccgga ttctgaatcg gacgctgttt ccttttctgt 2784781 catccaatca ggaagctttt cttcacgaat cactttttgg tttcgtttcg aagactttgt 2784841 ttttccctca gcccattcaa gatactggcg gttttcttct attgcgagct tcatcgcttc 2784901 cctgaccgtt ttcacctttt tgcgtgccca atgcgaagcg attttttgga tatagttttt 2784961 cgacagcttc atgtcggttt tcagcatgac ataataaatt aacacatttg tgacgcctgg 2785021 ctcgagcttc tgttcgaaca taatttcttc tatgatcttc agatcagctt ttgacggctc 2785081 tgttccgtca gcaatgtcct gcagaagctt cttcggggaa atcgcctcca gcaatgcaat 2785141 cagcttccca tccagagaat cctcttctgc cggttgttcg ccttcacgca gatgcaccgg 2785201 ctgtgttttt tccaccaaat cgggcagctg tccgtttctt tcaatttgat accagtcgct 2785261 cgccgctttt cttaatgcct ccgtcgtaat gacgtcacgc tcatcaattg cgctcatcac 2785321 aacattttgc atttgcaaag ggtcaattcc gtacagataa gaaagctttt tgattgtgtc 2785381 ccgcacctgc tgggtcatcg cttttctcgg tatcatcgtc tcagaaagtc ccgctaaaaa 2785441 caaatcaaaa tcaaacacat cctccgttat ggtgtaggac ggagactgtc cgacagaagt 2785501 atactcggac ccctcggcaa gccttaccgt ttcctccata tcggatgtga gcttccattc 2785561 actcggctgc agcgattcaa acgcatgatt aaacggacgc gtaatgtcct tcgcatcttc 2785621 tgaaatggcc gggtgcgtaa aaaattgttt taattgctga tatttcgttt ttccgaccct 2785681 attatacaga aaaacattca gcattccgtc ttcaaaaaat tcatttggtc tgagcggcgg 2785741 aaggagttca tatataaaga ggcgctcctg ccgctcggat tctttcatat atactttcag 2785801 caatccgatg ccctcgagct tcccctgttc ctgatggatc gtttttaagt tggactgtgt 2785861 catccccatc agctgtctat gtgtggactc tccgccccac agacggtttt gttcaagctc 2785921 tccccacaat gtcatataaa gagagaatgc aacagggccg attaagggct ggtacagttg 2785981 tgtaataatt tgtctgtcaa tatcctgcag catcgatctg cttttaacca catacgggtc 2786041 tacaggcagt acatctttcc aatagtcagc catacattct caaaccttcc gaatttgttt 2786101 ctacctttca ttttacaccg tttcttatat ctatcaaatg ccaattttgc acatgagaaa 2786161 agagctagaa gaatcctctt agctctttta acgctctttc tttattaagt cttttaattc 2786221 atcgataaag acgtttatat ctttaaactg ccgatagacg gacgcgaacc gcacatatgc 2786281 gacttcgtca atcttagcca gccggtccat gaccatttct ccgacgagct cactcttcac 2786341 ctcggagcag ccttgattgc gaagttcttt ttcaatatca aagcacatgt cttcaagcgt 2786401 tttgagtgaa acaggccttt tttcacatgc ttttatgagg ccgcgcagca ttttttctct 2786461 gctgaattcc tcacgcacac cttctttttt cacaacgatg agcggggttt cctccacttt 2786521 ctcaaaggtc gtaaaccggt agtggcagga ttcgcactcg cgtcttcggc gaatcgactt 2786581 tccgtcatcc acaggccgtg aatcaaggac tcgtgttccg ttatgctggc atgaaggaca 2786641 tttcaataaa atcagctccc aactatatcg ttccctgcaa tgtattttcg gcagcctccg 2786701 ccttttaaaa atagatgtga cagcatctgt cgggagagcc gttgttaaat ttgtttctat 2786761 agcattaggt ggtttgtgaa aatctccttc ttattttaca aaaaaaatga aaaaagaaaa 2786821 agctgacact ctcgtttctt tataaaaata aaaggagcat aagctaaaaa gcgcataatg 2786881 gctttctagc ttcagctccc tttgtgttcg caatttactt tatagtactt tcgcttgcgc 2786941 ctgtttaatt tgcacaggcc ccattcctct tggtatttca atgttttctc ttgtatcagc 2787001 atgtaatgcc tctgcaatgt aatcagcagc gacattagga tctaagtctc cacaagtata 2787061 aacatcaatg ctcgcatatc cgtgctcagg aaaactgtga atcgttaagt gtgattcaga 2787121 aataatcaca actccgctta cgccttgcgg tgcaaatttg tgaaatgcaa cctcgcgcac 2787181 ctcagcacct gattttagag cagcatttac aaacgttttt tcaataaaat ccatgtcatt 2787241 cagcttatca aaatcgcatc cccatagctc ggagataacg tgacgcccca ttgtttccat 2787301 agtcatggac cccccttaac aagaattaaa aagtgaaatt ccaacaactg ggtcggccat 2787361 ttaccacggg ggaaagttag tccggagagg tcctaaccct ttaagtaatt ccgaaacagt 2787421 ctcaagcaag aagttcacga aaaatagtat actgtgttta agtctaattt gcaaggtgcg 2787481 ttttttcaga aatatgctgt taagggtttt ttctttaaaa tgtgtccatg accttatttt 2787541 atacagcaga cggatgtttc attcgtgccg ctacatggcg gattagatca acaactctgc 2787601 aggagtagcc ccattcgttg tcataccacg ccagcacctt tactttcctg tcttccatta 2787661 ccattgttgt aagcccgtca atgaccgctg aatgcggatt cgtattataa tcagtcgaaa 2787721 cgagcggttc atctgagtaa tcaagtacac cgtacatcga cgttttggca gcgcgtttaa 2787781 atgcctcgtt tacttcttca gccgtaacat ccgttttcag atcaacaacg agatcaacca 2787841 atgagacgtt cggaacaggg acacgcaagg cgaggccgtg aagttttcct ttcagatgcg 2787901 gcagcacaag cgaaagcgcc tttgccgctc ctgttgttgt tggaatgatg gattcaccgc 2787961 aagcccgcgc ccggcgcaaa tctttgtgcg ggttatcaat atttttttgg tcattcgtat 2788021 acgcatgaac tgtagtcatc agaccgctct caatgccaaa ctcttcatcc agcactttta 2788081 caacaggcgc aaggcaattt gtcgtgcatg acgcatttga aataatgaca tggcgctcag 2788141 cgtcgaattg gtcctcattt acgcccatca caatggtaac gtcttcattt tttcccggag 2788201 cggtcaaaat cacttttttt gcacctgctt ctatatggcc catcgcttta tctttagcat 2788261 taaacttccc tgttgcttcg acgactatgt caatatcata ttcccgccaa ggcagctgtt 2788321 ttggatcacg gctgtttaac aaaagcactt tctttccatt tacgatcagg ctatcttcac 2788381 cagccacaac ctctttgtcg tatctgccgt gaattgtgtc atactttatt aaatgagcca 2788441 gcgtttctgc ggaatagctg gcgttaatgg ccactacttg aatttgatcg tctaacatcg 2788501 cttttctaaa aaccattctt ccgattcttc caaacccgtt gatcgctact tttaccttca 2788561 tgttggacac cccttatcaa ttatgccatc ctaatttgtt actatctaaa attagtataa 2788621 cacattaaaa caaattcgcc agtacatatt gataaaaatc aacgattata acgctaattt 2788681 atgatgcatc ttatgttttc ttgcacagaa tatcaggcgt aagaaccaaa aagcagccag 2788741 cgctccgcac tgactgccct catgctttat gattcctgtt ttaacttatc attgagcaca 2788801 ctttcttcta gcacagaaaa tgtatccccg tacactctgt taatatgatt cgctccccaa 2788861 gcacacagca tatctaaaat cccttctaag ctgcggccgt attcgctgag ctcgtattcc 2788921 actttgggag gaacttgatt atatacgatt cggttaatga caccgtccgc ttccagctcg 2788981 cgcagctgct gagtcagcat tttttgcgtg atattgggca ttaggcgttt taattcactt 2789041 gtgcgttttt ttccgtgcgt cagatggcat aaaatgacgc atttccattt cccaccgatc 2789101 acttcaagag tcgcttcaac agaaatgtta tattttttct tctccataca atccattctc 2789161 ctcacaggca ccaaaaagtg actatagcac ttcaaagtac gtacttttat ttcttaacga 2789221 tatgtttcat aatcacattt gccggctgat ttgaatctgc tcttttttat ttatatagct 2789281 tactcggcag aatttcaatc atacaacaca tcttacaaag gaggaacatc atgacttcag 2789341 ccaataaaag caatattcct gcactactgg ctttggccgt aagtgcattc gcaataggga 2789401 caactgaatt tatcagtgtc ggccttttgc cgctcattgc tgatgacctg gatattcccg 2789461 tcacgacagc aggattgacc gtttcccttt atgcgctcgg cgttacattt ggggcaccta 2789521 tattaacttc attgacctca agcatgtcac gtaagacact attgctttgg atcatgttta 2789581 tttttattgc cggtaatacg atggcagcaa ccgcttcaag catcgggatt ttactagcag 2789641 cacgtgtgat atcggcattt tcgcacggtg tgtttatgtc gatcggttcg acaatcgcag 2789701 cggatattgt cccggaggat aaaagggcta gcgcgatttc aattatgttt actggcctca 2789761 ctgtggcaac tgtaaccgga gttccttttg ggacatttat cggccagcag ttcggctggc 2789821 gtttcgcctt tatggtcatt atcgccgtcg gaatcattgc tttcattaca aatggcattc 2789881 ttgtaccgtc caaattacga aaagggacga aaacaacgat gcgggatcaa ttgaagcttg 2789941 tgacaaacag ccggttattg cttttatttg tcattacagc gcttggatac ggaggaacat 2790001 tcgttgtgtt cacgtatctg tctcccctgc ttcaggaagt aacaggcttc aaagccggga 2790061 ctgttgcagt gattctgctc ggatacggaa tagctattgc tatcggcaat atgattggcg 2790121 gaaagctgtc aaaccgaaat ccgattgccg ctttattcta tatgtttatc gtacaggcaa 2790181 tcgttctatt cgtactgaca tttacagccc cgtatcaagc agcagggctc attaccattc 2790241 tctgtatggg attgctggcc tttatgaacg tgcccggcct tcaggtgtat gtcgtcatgc 2790301 tggctgagcg ttttgtcccg agtgcagttg acgtcgcatc cgcgatgaat atcgctgcct 2790361 ttaatgcagg gatcgcgctt gggtcatacc ttggcggtgt gatcaccgat tcaatcggat 2790421 tgattcatac cgcttggata ggcggattaa tggtggtcgg tgcagtcatt ttaacaggct 2790481 ggagccgctt gatggaaaaa cgagatcggc aggaagcctg acaattttaa aggaggaaat 2790541 aaacatgaca acacatttac aagcaaaagc aacacttcat aatggggtag aaatgccttg 2790601 gttcggcctc ggcgtgttcc aagtggaaga aggatctgaa ctggtaaacg cagttaaaac 2790661 tgccattgtt cacgggtacc gcagtattga tactgcagca atctatggaa atgaagctgg 2790721 agtcggagaa gggattcggg aaggcattga agaagcaggc atttcaagag aggatctgtt 2790781 tatcacatcg aaagtatgga atgcggattt aggctacgaa gaaacactcg ccgcgtttga 2790841 aacaagtctg tccaaactcg gtctggatta tttggatcta tacctcatcc actggcctgt 2790901 agaaggaaag tataaagaag cttggagagc gcttgaaacg ctgtataaag aaggccgtat 2790961 caaagcgatt ggcgtaagca acttccaaat tcaccatctt gaagatctga tgacggcagc 2791021 tgaaattaag cctatgatta accaagtgga atttcacccg cgcctcacac aaaaagagtt 2791081 gataagatac tgccaaaatc agggcatcca gatggaggct tggtcacctt taatgcaggg 2791141 acagctgctg gatcaccctg tattggctga catcgctcaa acatataata aatctgtcgc 2791201 acaaattatt ttgcgctggg atctgcagca tggcattata acgattccta aatcaacgaa 2791261 ggaacaccgc attaaagaaa atgcaagcgt atttgacttt gaattaacgc aggatgacat 2791321 gaaccgaatc gatgcactga atgaaaactt gcgcgtcggt cctgatccgg acaactttga 2791381 tttttaatgg ccaaaaaaca ccgttcaata tgaacggtgt tttttgtatt atgcccagct 2791441 gttcatgatt tcatcaagct gccttttggt ctcttcaagc gtgccgctgt tatcaatgac 2791501 ttgatctgct cttgctgttt tttcctctaa gggcatttga gagcggatac ggctgactgc 2791561 ttcttcttct gtcagctgat tgcgcttcat cagacgttcc agttgaagct cttttgtcac 2791621 actgaccaca ataattttat caaccaatga ttccaatttg ctttcgaaca atagcgggat 2791681 atccaataca acaaatgcct cccgatttgc aacggcttca tcacggcgat tgagcatttc 2791741 ctgcctgact gcgggatgaa caattgcatt taaagcgaga cgtttttgtt catttgtaaa 2791801 taccagcgct ccaagctttt ttctatctat atcgccattt gagagcagta tgtcttcacc 2791861 gaattcgtca atgatttgcc ggtaggccgg catccctttt tctaccgctt gttttgcaat 2791921 gatatctgca tctataactg ttattccttt ttcaatcagc atattggcta ccgtgctttt 2791981 gccgctagct attcctcccg ttaaaccaat gactaaggtc aagagatcca ctccttttta 2792041 caatttccag agcccaatcg tgattaatag aagccccggc aaaaacgcca ttttatcgat 2792101 ccatttccac ttagacagaa aatggccggc attgattcca attgatacaa acagcgagct 2792161 catgattgcc acggcgatgc tcatcacaat cggcgaaaaa ccgagaatgg ctgcgcctat 2792221 acctgctcca aaggcatcaa tcgataaggc aaatcccaat aagaccgcct caattccgtt 2792281 gatcacaccc gatttgtcga tatccgcact catgggtttt ctcaaaatat gaatcacaat 2792341 tcctaatgac cgaacctcta gattaagcag tgttttttca tgcaataggt attctttatc 2792401 ttttgccggt ttgaaaaatt gatacagaac ccacgcaccg attccaacca atatcaaacc 2792461 gccaagcttc tccgtcacat atacaggaaa aaacttcgtg agaaagcttc cgatcagcat 2792521 ggatataaac atgacagcac cggaacagca ggcgataacc aaaatcgctt taaacggtat 2792581 tttcattttt ctcaatccgt acgtaaatcc gactgaaaaa ctgtccaagc tgacagccaa 2792641 cgccagcagc agtatagaaa ccatttgcat atccgtttct tcctttctgt tggtgctctt 2792701 gtatcagatg tgaaatgccc gggattcatc acaatcatat atatgggaaa gtgaaaaatc 2792761 cgtgtttcga aaatggcatc cttaatccag agttactgat atatgcaccg acagcttgga 2792821 caatgaagca ttatgctact tttttgtctg gcactttgcg caaaaatgcg tgcctcttcc 2792881 tccaacgaca attttcgaaa tcatcgttcc gcaatttttg catggctcgt ctttttttcc 2792941 gtacacaaaa tgctgcagct ggaacattcc gatttcccct tgggagttga tatatgaacg 2793001 gactgtgctt ccgcccgcat caatcgcctc ctgcagagtg tttttgattt cagcgtgaag 2793061 ggttttgatt gttttatctg ataattgatt tgcttttgtc tcgggatgga cacccgctct 2793121 gaaaagagcc tcatccacat aaatgttccc gagtccaact accgtttttt gatccagtag 2793181 ggcagttttg acagcgcggt ttgttttcgc aagccggtct tttaaatacg cacttgtaaa 2793241 ttcttctgca tccggctccg gccctaactg agaaagcggg agctcgcccg cttcttctcc 2793301 cggtttaaat aagtgcatgg ttccaaattt ccgcacatcc ctgtaccgga gctgggttcc 2793361 atccgtcatc gtgaatatga catgcacgtg tttatcgtca ggctcctcgg cttgatgaag 2793421 accgtatttt ccttccattc gaaggtgaga aaccataaca taatgatcta aatgaaacag 2793481 taaaaacttt ccccgtcttc cgatggactg tatcgtttct cctgctagtt ttcgcgcaaa 2793541 ttcctccggt tcggcaggcc gtttgatgat attcggccat ctgatctcta ccgatttgat 2793601 tgtttttccc tttacaagcc cggtcagagt gcgccggacc gtctcaacct ctggtaattc 2793661 cggcacatcc atcacttcct atctctgttt atttcgcatc gtaccaagat gggcctgatg 2793721 caaagtccac ctttaacggc acatctaatg caagcgcatg ctccatcact tcaggaacaa 2793781 gcttttcaag aatttcaatt tcttcctttg gcgcctcaaa aatcaattca tcgtgtactt 2793841 gaagcagaag ccttgctttc aactgttttt ctttcagctt ggcagccatg tcaatcatgg 2793901 cttttttgat aatatcagcg gcgcttcctt gaatcggcgt attcatggcc gtccgctccg 2793961 caaaacttcg gatattaaag ttccggctcg tcagctcagg gatgtagcgg cggcgatgca 2794021 taagcgttgt tacgtatcct ttttgtttcg cttcctgtac tgaatcttcc atgtacgctt 2794081 ttacgccttg gaagctttcc agatagcggt cgataaatgc tcccgcttcc ttccgggtaa 2794141 tgccgaggtt ctgtgacaga ccgtaatcgc tgatcccgta aacaatgcca aagttgaccg 2794201 ctttcgcctg gcgtctcatc gcagatgtca cttcatcctt agcgacatgg aacacatcca 2794261 ttgccgtttt cgtgtgaata tccatatcat tagtaaaagc ttcgatcaga ttttcatcct 2794321 ttgaaatatg ggcaagcacc cgcagctcga tttgtgaata atcggctgca aaaatgagcc 2794381 agtctttttc agacggcaca aaagcttggc gaattttccg cccttcctca agcctgatcg 2794441 gaatgttttg caggttcgga tcagtcgagc tgagacggcc agtttgcgtt aaggcctggt 2794501 taaatcgcgt gtgcacttta tgcgaatccg gtctcgtcac ctttaaaagc ccttcgatat 2794561 atgttgattg aagcttgcca atttgtctgt actgtaaaat atagtcgaca atatcatgct 2794621 tgtcagccag cttttcaagc acatcggcag acgtagaata gcctgttttc gttttcttta 2794681 cgacaggaag gccgatcttt tcaaataaga tgacgcctag ctgtttcgga gaattgatgt 2794741 taaacggctc tcccgcaatc tcatggattt tttcttcata ttccttcagc ttcgcaccca 2794801 gttcttcacc catccgtttt aaacggtcaa catcgacctt gacgccagtt gattccattt 2794861 cgccaagaat aagcgcaaga ggcatttcca gctcttcaaa cagttcaagc tggtcgttgt 2794921 tttccagctc ttgaacgagc ttttcccgaa ggctttgaat cgctaacgct tttcggccaa 2794981 ggtgctcaga cagtacgtct tctgacggca ctgcccgttt tgctcctttt ccataaactg 2795041 attcatcact tgaaacgata tgcaggccgt aatccttagc cacactcgca acgtcgtcat 2795101 atgaattgcc cgggttgatg atataagccg caaggagcgt atcaaactcg gctcctttca 2795161 gctcaatgcc ctgccagcgc aaagcgacaa cggcccgctt gctgtcgaag acccatttct 2795221 tctgctcgtc attttccacc cattctttaa acacctcaga ctcaacggca atgtctttcg 2795281 gaatgaaata agctcccgtt tcatttacga tcgaaaatcc gaggatcggc tcttcatgat 2795341 aattatcgcc aatctgttca acgacaaatg cggatggaga aaccaatata tcgcttgtca 2795401 cgtctgtgac tgttttgaca ttaatgtctt ccaacgattg atcctgttct gcttctgcac 2795461 tgtcttctcc aagccgttca agaagcgtgt tgaagccaag atctttaaag atggcaatga 2795521 cctgttcacg attaaagcct tgatattcca ggccggaaac agatacctca atcggagcat 2795581 ccgtcataat tgtcgcaagc tccttgctca tcaatgcctg atccttaaac tcctcaagct 2795641 tttccttcaa tttctttccg ctcacctcgt caatggactc cagcagcttt tcaacggaat 2795701 caaattgttt taaaagctta atcgcagtct tttctccgac gccgggcaca cccggaatat 2795761 tatctgagga atcgcccatc agacccttca tgtcaatgat ttgttcaggc gtaagcccat 2795821 atttctcttt gacatgctcc ggtgtgtaaa attcaacatc ggtaattccc tttctcgtaa 2795881 tggcaactgt cgttttgtcc gttgccagct gggttaaatc cttatctcct gagaaaacct 2795941 taacttcaaa tccgtctttt tcagccgatt tggccagtgt gccgataata tcatccgctt 2796001 catattgttc cagttcatag cggctgatct ggtaggcatc cagcagctcg cggataaacg 2796061 gcatttgttc ggaaagctca ggcggggttt tctgtctgcc gcctttatat tctttaaatg 2796121 tgccgtgacg aaatgttgtt ttcccggcat caaacgcaac cagcatgtgc gtcggttttt 2796181 catcctcaag cattttcatc aaaatcatcg caaagccgta tacagcattc gtatgaacac 2796241 ctttatcatt gcttaacagc ggcaatgcaa aaaacgcccg gtaagccaga ctgtttccgt 2796301 ctacaagcac taattttttt cgttccgtca ttcaatttcc tcctaagaag cctcaggctt 2796361 ccattcatct cttacatagt cattagctcc tcttatttta acaaagttca atttgaaagg 2796421 aaaatacgtg aactataaga gaagacacaa aaaaggacgg gaacacaaat aggttcccgc 2796481 cgtcaaaatt ggctccttgg atgaaggggt tctactacat cctaccagca taggtttaac 2796541 agtgcatgaa gatattgtta aacctttgta aacattaggc ggacttttca gcggcccgtt 2796601 tcagcgtcac ggtaaagaca gttccccgtc caagctcgct tgtgacatca attttccctt 2796661 catgagcctc tattaaatgc ttgacaatcg ctaggcccag cccggttccg cccgaatttc 2796721 tgcttctgtc tttatctaca cggtaaaagc gttcaaagat gcgcggaatt tcttctttct 2796781 gaattccgat tccagaatcg gcaacctcaa tctgaatgtc tttttctctg ggctttacat 2796841 tgatagccac ggagcccccc tcaggcgtgt aggttaatgc attgtttacg agattaagaa 2796901 atacctgttt cagcctgtac gggtcaccag atacatattg agggtctttc gggacattca 2796961 ggtgcaagga gatgcctttc tcatccgcct tatgcttcag aagcgtttca atctcaccaa 2797021 gcattttggc cggctcaaac gtttcgatac tgagcgtgaa attttgctgc tcgatttttg 2797081 agagatcgag caaatcctga accaaagact gaagcctttc gctttcctta agaataatag 2797141 agagaaattc agaaagcgcc tctttgtctt ccatcgcccc gtccaataac gtctccgtaa 2797201 acccttttat ggacgtaatc ggtgttttca gctcatgaga aacattggcc acaaaatcct 2797261 tcctcatctg ctctaatttc ttcgtttccg tcatgtcatg gaaaacgagc acaattcctt 2797321 tccattcatc gtccggcccc ataatcggaa cgccgtccac ttcaaaataa cgccgttcta 2797381 ttttgatcgg cagtcttaac agcttgcatt tctttgtctc cgtcataaaa atgtcttcga 2797441 caagctggat cacttcttca tgttcaaatg catcgtgata aagacggcgc agcatatgat 2797501 tcggattgat atgaaactgc ttggcgtaag acctgtttac gagattaata aagcctcttc 2797561 cgtcgatcat aatcagcccg gagccaatgt tttcaatgac tgtcagcagc cgatcccgct 2797621 gcatttcctg cgttcgcgtc atttccatca gatcaatggc aaggctgttc atcgcatgtc 2797681 ctagcttatc agaacgccta atatagccgc cgtacgtccg tgcatcgtag ttgcccttag 2797741 agagttctgt ggctacattt gtcgctgact caattgacct tttataacgt gaggtcatgc 2797801 tggaataaaa ataaacaatg acgataaatg cggtacaaag actggccgtc agcatccccc 2797861 acaattcgcc ttttaagccg tcgctttttt cagaggcgga aagcagcaca tatcctgttt 2797921 tttcaccttc gcttctaagt gaaagtccgt aataaagctt gttatctgtt gttgacagaa 2797981 taccctcatg gccagaaaca agcgcctgca ccttttggga atcagccgat ctaccgtttg 2798041 acccatacag caccttaccg tctgtatcga taacggatgc gctcacatca agcgcgccgc 2798101 ctgcatcttt aatgattttc tcatttgctt gattattcag attgccggca tcaagaagcg 2798161 aagccaagta ttttgcttct ttttcaatgt gttcctctgc tttcctttga tcagatgttt 2798221 caaaaagctg ctgtaaaaac agcccgagga cacaaaacac cagaatcata cagacaacga 2798281 atacagaaaa aaggcgcaca cggtatttat tcattcattt ttggctcctc cagtttatac 2798341 cccaatcccc taatcgtttt aatgtagatc ggttttttgg tattgttttc aattttgtcg 2798401 cgaagatggc tgatgtgcac atcaacaatt ctcgtatctc cggcaaaatc ataattccag 2798461 actgcgctca gcagcaggtc tcttgtcaga actctgcctt tatgtctgcc taaatagagc 2798521 agcagttcga attctttcgg tgtcagttca agctgacttt ctttaaagta cgcttcataa 2798581 tgatcaggca ggattttcag atcgccgatt acgatctggc cttccatttc atcgttcttc 2798641 atctcactag agggcgcagc tatttccgaa cgccttaaaa tcgctttgac tctcgcattt 2798701 acttcccttg gactgaacgg cttggtcata taatcatcag caccgagctc cagccctaat 2798761 actttgtcga attcctcatc cttcgctgtc agcattaaaa tgggaaacat cagtttttgc 2798821 tgtctcagct gcttgcatac ttcgattccg tccaattttg gaagcatcac atcaagcaca 2798881 atcaaatcag gtttctctgt ttccgctttt ttgagtgctt cttccccatc cgaggcggta 2798941 atgacatcat agcctgaccg ttccaaattg tactgtaaaa gagtaacaat agattcttca 2799001 tcatccacaa ctaaaatttt cttgttcatg ctgtgcctcc agtattataa ttccccgaca 2799061 tcctatttct ctattttatg tcatcttaac atgtttcatg attttatttt agcgaaagca 2799121 ggacattccg acaattcgcc ttttacatca tttttaaaag aaataaagac gtttatgata 2799181 gcgctttcat ttatagtaaa aagagaaagg ctgtattaag caagcctttc tctcttttta 2799241 ttaggataat actttcatga catttttgac agattcaact gatttattca gctgcgctct 2799301 ttcatagtct gtcagttcaa gttcaatgat ttgctcaaga ccgttgccgc ctacaattgt 2799361 aggaacacca aggtagatgc cttcatagcc gtattcccct tcaagataag caattgtagg 2799421 aaggacgcgg cgctgatctt tcaagatcgc ttcgaccatt tctgtcagag aagccgcagg 2799481 cgcataatac gcgcttccgt ttccaagaag attcacgatt tcgcctccgc cttttctagt 2799541 gcgctccaca attgcgtcaa tccgttcttt cggaataaga gtttcaagcg ggataccgcc 2799601 agcataagaa taacgcacaa gcggaaccat atcgtcaccg tgtccgccga gtacgaaacc 2799661 agtcacatct ttcactgaca ggtttaattc ctctgccaca aatgttctga atcttgccgt 2799721 atcaagcaca cctgactggc cgattacacg ctctttaggg aagcctgatt ctttgtacac 2799781 cgcgtatgtc attgcatcaa caggatttgt cagcaccaca ataatagagt caggagaata 2799841 tttcacgatt tcctgcgtaa cgcttctcat aatcttttcg tttgtagaga ccagatcatc 2799901 tctgctcata ccaggttttc ttgcgatacc ggctgtaatg acaacaatgt cagagccggc 2799961 tgtatcctcg taattggatg ttcccgtaat ttttgcgtca aagccttgaa ccgggcttgc 2800021 ttcaagcata tcaagcgctt ttccctttgt cgggttctcc aattgcggaa tgtcaacaag 2800081 aacaacgtct gccagctctt tttgagcgat taaaaatgca gttgtagctc cggtaaaacc 2800141 tgctccgata acagaaactt ttttacgagt atttcccatg tctctcttct cctttatggc 2800201 tagttttagg ctttttcctt gcttagtcca tgtttttgat cagttcttct ccgaactctg 2800261 aacatttcac ttcagtcgcc ccgtccatta atctggcaaa atcgtaagtt acgactttag 2800321 aagcgattgt tttttccata gatttgataa ccaaatcagc cgcttcgttc catcctaaat 2800381 gctcaagaag cagaacgcct gaaagaataa ctgaagatgg gtttacttta tcaaggcctg 2800441 catatttagg agccgttccg tgcgtcgcct cgaaaatcgc atgtcctgtt tcgtagttga 2800501 tgttcgctcc aggagcaatg ccgattccgc cgacttgcgc agcaagagca tcagaaatgt 2800561 aatctccgtt caagttcatt gtcgcaacga catcaaactc gtttggacgc gttaagatct 2800621 gctgaaggaa aatgtcagca atgctgtctt tgataatgat ttttcctgct gcttccgctt 2800681 cgctttgcgc tttgttggca gcgtcttttc cttgttcttc agcaatgcgg tcatattgag 2800741 cccatgtgaa gactttatct ccgtattctt tttcagcaag ttcatagccc cagtttttga 2800801 aggcgccttc tgtgaacttc atgatgtttc ctttgtgaac aagtgttaca gatttgcggc 2800861 catgctcgat cgcataatca atggcagctc tgaccaagcg gcttgttcct tcttctgaaa 2800921 caggcttaat gccgatacct gatgtctcag ggaaacggat tttattgacg tttaactcat 2800981 tttgaaggaa gctgataagc ttttgcactt cttcagagcc ttttgcatac tcgatgcctg 2801041 cgtaaatatc ttctgtattt tcacggaaga tgaccatatc agtatcttca gggcgtttta 2801101 ccggtgacgg cactccagta aagtatctta caggtcttaa gcagacgaat aggtcaagct 2801161 cttgtctgag cgctacgttc aaagaacgga taccgccgcc gacaggtgtc gttaacgggc 2801221 ctttaatcgc gatgaaatat tcgcggatca catctaatgt ttcagcaggg agccactcac 2801281 ctgttttatt ataagccttt tctccggcgt aaacttcttt ccatgtaatt ttcttttcgc 2801341 ctttgtatgc tttttctact gctgcttcca aaaccttcga agccgcgttc caaatatcag 2801401 gaccggttcc gtctccttcg ataaatggga taatcgggtt gtttggtacg tttaatactc 2801461 cgttagagac tgtaattttt tcaccttgtg ccacaataaa aacctcccag tatgtaattc 2801521 atatttagaa aacattttat ttttcttata tagaaaataa aatgattttt cctaacattc 2801581 aatttaaagt gtaacccaat tttgatgtct gaacaagagg ctaacctcat tgacgcaagc 2801641 cagcctccaa tggttcttta ggctctttct tcaatcggaa cgaatttttg tttgtcaggg 2801701 cctgtgtaat ctgcccgcgg gcggatcaga cggttgttgt catactgctc aagaatatga 2801761 gcgagccagc cggacattct gcttacagca aaaatcggtg taaacaaatc atggtcaata 2801821 ccgaggctgt gatatacaga agccgaatag aaatcaacgt taggcggaag ctttttctct 2801881 gatgtgacga tgtcttctat acgaatcgac atctcatacc atttgctttc gcctgtcagg 2801941 ttggtcaggc gcttgctcat ttctttcaga tgcttcgcgc gcggatcacc atgcttatac 2802001 acacggtggc cgaatcccat gattttttct ttcttttcaa gtttagcgcg gatgtacggc 2802061 tcagcgtttt ccacttcacc gatttctgtc agcattttca taacgccttc attcgctccg 2802121 ccgtgaagag gccctttcag cgcgccgatt gctgcagtaa tgcctgaata gatgtcagaa 2802181 agtgttgcga cgcagaccct cgctgtgaac gttgacgcgt tcagctcatg gtcagcatgt 2802241 aaaatcaatg ctttgttgaa ggcttcaact tcaattggtg aaggctcttc accgtttaat 2802301 gtgtaaagaa aattctccgc aataccgtaa tcttctctcg gttcaacagg ctcaagaccc 2802361 ttgcgaattc tggaaaacgc tgcaaccagg ccaggcacct ttgcctgaag gcggatcgcc 2802421 tttctgtagt tggcttccgg gttcatggta tcagcctcgc tgtcaagcag gcctagtaat 2802481 gaaattgctg tccgaagagc agccatggga tgaacatttt cgagggaata agatttgaag 2802541 tgctcaataa tttcttgcgg aacggcagct tcctttgcaa gctgctgctt taactcttca 2802601 agctcttttt tgtttggcag ccttagatgc caaagcaagt agatgatttc ttcaaaactt 2802661 gcattctctg tcaaatcatc gatatcatac cccacatatg taagggtatc atcaataata 2802721 gaactaacag atgatgttgt tgctacaacc ccttcaagac cgcgtgtcgc tgtcatatat 2802781 aacatctcct tttcaataaa tttccccttt aagagtgttg taaaaacatg aggcttactt 2802841 aaaaagcacg atgcaagtat ttctctcccc caaaaagaaa atgcttacat tttactggct 2802901 gctggaacta aaaccctttg cttttgaaag aacataacaa atttttataa gcttatttaa 2802961 gtttaagcct attctcatta taaacaataa tcagacattt gttaaatgtt tacctataat 2803021 tttttttttc cattctgtga tttccccgaa aaaacgcctt tatttgcggg tttttgcata 2803081 aaaaaaagcg gctttaaggc cgcttttttt tatgaagtga acagttttac gatctgcatg 2803141 gctaaataag caatccccgc tccgatcagc ggccccaccg caactcctcc aaaaagcgcg 2803201 actgcaagaa tggtcccgat cacgagagca gttgtaatat gcggatcatt ttcaagcagg 2803261 gtcaggccgt tttttgcaat cagcgccact gcgatccccg ctccaagggc gatccatgcg 2803321 taggaagacc gcattgcttc tccaagctgc ttaaatccga tttctcccgt ggcaatcggg 2803381 acaagaacgg cgatggtaat aatggtcaca ccccagttaa tgccttttga ctggatggtc 2803441 ggaaataatt tctgatcaag cccaacgatt ttgatgatca aaaggacgga tacagcaaag 2803501 agcaatgatt ggttttttgc gataagtgcg atagccaaga gtaaaattaa aaataaattc 2803561 gcttgtgtaa acacatgcca tccctccttt aagatgaatg tattcatatt cagccgcagc 2803621 gtgaatacat ataaaaaata ggacatgctg acgagaggag gaccgttttt gtgaatcaat 2803681 cttatatcac tatttttttc agaaccctct ttgtcatatc aatgaccgca gggtcgatag 2803741 ctgcggccta ttattcgttt ccgttaactt atccgttcct gatcgccctt attctatctt 2803801 cagtgattca tcctgttgtc gattatttgg acaaagtgac aggattcccc cgaacgataa 2803861 atgttctggg cgttcttgct ttttttctgc tcgcagcctt cggcgtgctc accattctgg 2803921 tagccgaaat cgtaacggga acagcctatc tagcaaaaac gctgcctccg catatcagca 2803981 cgtttatttc atattgcgaa aaattgttta ccactcatat tcagccgctc tataacgagt 2804041 taactctttt gtttcaagaa ttggaaacga accagcaggc ttccatcgtc actcatatcc 2804101 agacactcgg tgattctgcc gctaaaaatg ccgggctcct gctgtcccac attctagaga 2804161 tgatcccgag atttttcgct cttcttccca atacggcggc ggttctgatt ttttctcttc 2804221 tggcaacctt ttttatgaca aaggattggc ataagctgaa agccatgctt gttttaattc 2804281 tgccggatcg tgtgacagct aacagcaaag caatcagcag cgaattaaaa aaagcaatga 2804341 ctggttttat caaagcacaa gccgtcctcg ttttcatcac gatggtgatt gtatttatcg 2804401 gcctttctct cttaaaggtt gaacacgccg caacaattgc ttttttaatc gggcttgtag 2804461 atcttctccc ttacttaggt gccggctccg tatttgtgcc ctggattttg tatttatcga 2804521 ttacgggcca gctgccccaa gcaatcggaa ttggtatcct gtacctcgtc gttcttattc 2804581 agcggcagct gacagagccc aagatactaa gtaaatctat cgggatcgat ccgctggcaa 2804641 cactcatcgc cctgtttgcc ggctttaaat tattcgggtt tttaggactg attgcgggac 2804701 cggctgtact cgtcatcatc caagctttca tcacaacagg cgcattaaaa gaaatatggt 2804761 cctatatcac cgttcagcaa aaataaaacg gcagccgttt tttcatggct gccgtttttt 2804821 atttgatgat gatccgctta ttcttcgaca ttcctctcag ccatttgaac agaatcggct 2804881 tacaccagcc gcgggtaaac gggataagaa gacaggcgcc ggccaaatct gataaaaagc 2804941 ccggaagcat cagcaataga ccgccaatga aaatgcacag accgtcagca atcgcttctc 2805001 ccggcatttt gccatattga agatcacgct gaaccttata atacacttcg gttccttgtt 2805061 tttttgcagc tgctgcgccg ataatgccag tcagaatcat gaatagaact gtcggcaaaa 2805121 taccaatcag atttcctaaa aataggaata taccgatttc tattgccgga aacacaataa 2805181 aaagcaaaaa caaaaatctc atatccaagc cccccacacg tgtaacacgt tctgttcaac 2805241 aaaaggcatg ataaagagaa aaggaaggga ttccccttcc attttcacct gtaattaaag 2805301 aacgctcgca cggccttgat agactgcgcc tctggaagcg tcaactgtaa tatcctggcc 2805361 atctgtcaaa atagatgtcg cattttccag acccacgata accgggatgc caaggcttaa 2805421 tccgactacc gcagcatggc tagtcaaacc gccttcttct gtaataagag cagacgcttt 2805481 ttcaagggat gcaatcatat cacggtcagt gcttttggta acaagtaccg caccgtcagt 2805541 cattttttgc tcagcttctt ttgcattttg tgcaacgaca accggaccgt aagctgattt 2805601 gcgtccaatg ccttggcctt tagcgatgat atcgccgaca gtatgaacct tcattaagtt 2805661 cgtagtgccg gactcaccga cagtgccagc tgtaataacg ataagatcgc cgtgttttac 2805721 aattccgctg ttcaatgatt tttggacagc atcctcaagc atctcatctg ttgagctcgc 2805781 attttggccg ctttccgcga atacgccaga tacgagggca agctttctgg aaatagagtc 2805841 atttacagta accgcaacaa tcggagcctg cggacggtat tttgcaatca tacgtgctgt 2805901 atggccgctt tctgtcggcg ttacgatcgc agcagcattc aggttaatcg ccgtatgtgc 2805961 gacagattgt ccaattgcgt ctgtaattgt catgcccact tggtctctgc gttttgagag 2806021 aatttcttta taatttaatg cttcttcaga acgggacgcg atgttatgca ttgtttgaac 2806081 tgcttcaacc gggtaacttc cggcagcagt ttcaccagaa agcatgatcg catctgttcc 2806141 gtcgaagatc gcgtttgcaa cgtcacttgc ttccgcacga gtcggacgcg ggttgcgctg 2806201 catgctgtca agcatttgtg tcgctgtaat aacaggtttg cccagcgcgt tgcatttttt 2806261 gatcagttct ttttgcacaa gcggcacttc ttcagctgga atttccacac ctaagtctcc 2806321 gcgtgcaacc attaagccgt cagacacttc gagaatcgca tcgatgttgt caacgccctc 2806381 ttggttttcg attttaggga tgatttgaat atcctgagcg ttgtgctctt caagaagctc 2806441 acggatttcg agcacatccg tagaacgtcg aatgaaagat ggtgcgatga agtctactcc 2806501 ttgctcaata ccgaaaacga tgtctcgcgc atccttttca gtaatccccg gaagattgac 2806561 acttacgccc ggtacgttaa cacctttttt atttttgagt gttccgttgt ttaatacttt 2806621 tgttttgatt tcgcgtttag cggcatctac atcaagtacc tcaagaccga taaggccgtc 2806681 atctaacaga atcgttgaac cttgttcaac gtcatggact aaaccttcat atgtcactga 2806741 aattttatct gttgttccta caacctcgtc cattgaaata atgagctctt tgcctgtttc 2806801 aagctcaata ccgccgtttt ccattgtatg tgtgcggatt tcaggacctt ttgtatcaag 2806861 cagaattcca acgttcttgc caagtttttt acttgcttcg cggatatttt taattcttgc 2806921 accgtgctcc tcaaaatctc cgtgagaaaa gtttaatcga gccacgttca ttcctgactc 2806981 cattaatttc gtaagcattt caatactttc acttgccgga ccgatggtac aaacaatttt 2807041 agtttttctc atttggttca cttccttctg aaatcttcag ccttcagctg tacattagat 2807101 agacagttct tttgaaagct gatacatgtt ttgctcaact gtgtgttttg tctcaagtat 2807161 ttctataata tcatggtcta caagcttatt gttttgtata cctacacagc gtccgccttt 2807221 tccttcaagc agcagttcaa ctgcatatgc gccgagacgg cttgccaaca cacggtcagc 2807281 agcactcgga gaacctccgc gctggatatg gcccaataca gataccctag tttcaagatt 2807341 tgtttcttct tcaatgcgtt tcccgaattc aacaccgctg cctacacctt cggcaacaat 2807401 aataatactg tgcttcttgc cgcgttcgtg gccgcgtttt aagcgggcaa tgatttcgtg 2807461 catgtcatag tctgcctcag ggattaagat cgattctgcg ccccctgcaa gaccggccca 2807521 caatgcgata tcgccggcat gacggcccat tacttcgatt acatatgtac gttcatgaga 2807581 agtcgctgta tcgcgaatct tatcaattgc gtcaattact gtatttaaag ctgtatcgaa 2807641 accgattgta aaatcagtgc ccggaatgtc attatcaatt gtacccggta cacctacaca 2807701 tggaaacccg tgttccgtta attttttcgc acccatatag gaaccgtctc caccgataac 2807761 aacaaggcct tcaataccaa gcttcttcaa gtttgctatc cctttttcac ggccttcaac 2807821 tgttttgaat tcaggacatc tcgccgtata aagcttagtc cctccacgat gtataatatc 2807881 gcctactgat ccgagttcaa gcttttcaat ctttccgctg atcaatcccg cgtatccgtt 2807941 gtaaataccg taaacttcaa cgtcatgata gatcgctttt ctgactactg cgcgaactgc 2808001 tgcgttcatt cccggggaat ccccgccgct cgttaatacc cctattcgtt tcattctcca 2808061 ttcacctcag caacatatat gattaaacat aacatgatca ttgccctaaa aacaatgaaa 2808121 agggatctcc atcctcccta tgaaacctta cctattatac aattaaataa attgttttta 2808181 aataaaattt aaggaatgtc acaaaaaata aacgtgagcc aaaggcttca cgtttattta 2808241 gtttaccccg atatattgat cttcaaccga gactttgcca attgctttat atttttcata 2808301 acgctgctga actaattctt cttcgctcag cttcagtaaa gtttttaacg attgtttaag 2808361 ggtttcgtcc atatagcttg cctgcagctt cacatcatgg tgcgctccgc cttttacttc 2808421 tttaatcata tgatctataa tacctaattc ttttaaatcc ggcgcagtga ttttcattgt 2808481 ttctgctgct tttttagcaa gactggagtc cttccataaa agtgccgcgg caccttccgg 2808541 agaaataaca gaataagtag agttttccag catatgcaag tgattgccta cacccagacc 2808601 aagggctccg ccgcttccgc cttcaccaat gacgatgcag ataacaggca ctcgaaggcc 2808661 ggccatctca aacaggtttt tggcaatagc ttcactttgt cctctttctt cagctgctcg 2808721 tccagggtat gcccccttcg tatcaataaa acagataatt ggtctgttaa atttgtcagc 2808781 ctgtttcatc agacgaagcg cttttctgta gccttctgga tgcggcatcc caaaattgcg 2808841 gactaggttt tccttcgtgt ctttgccgcg ctgatgcccg attaccgtta cagggaggcc 2808901 gtggaacttc gcaatcccgc cgacaatggc ttcatcgtcc ccgtacgctc tgtctccgtg 2808961 acattcaaaa aagtcggtaa acaggtgttc gatataatca agagttgtcg gacggtccgc 2809021 cagacgcgcg atttgaaccc ggtcccacgg cttcaaattt ttgtaaatat catcctgaag 2809081 cttagcgaga cggtcttcga gccgttcgat ttccgcactt agatccatat cggaatcttg 2809141 ggtgaatttt tttagttcgg cgattttggt ttgcagttca atcaccggtt tttcaaattc 2809201 taatcttgga gccactcaat gtcacctcct gtttgatgca tatccagcag attttctaac 2809261 gtttttttca tatcgtcgcg atgaataacc gcatcaagct gtccatgttt taataaaaac 2809321 tcagccgttt ggaagtcctc aggcagtttt tctcctattg tctgttcaat aatccgtctt 2809381 ccggcaaaac cgatcagcgc gccaggctca gcgaaattgt aatcgccaag ggatgcaaag 2809441 cttgctgata cgcccccggt agtcggatgc gtcattactg aaataataag accctgttct 2809501 tcactgaaca gttttaacgc agagcttgtc tttgccatct gcatcaaact taatacgcct 2809561 tcctgcattc tagcaccgcc tgaagccgta aaaataataa acggaacttt atcagctttt 2809621 gctttttcaa tcgcaagcgt gattttttca ccgacgactg aacccatgct gcccattctg 2809681 aatgaagagt ccatgacggc gacaacagcc gggtgtccgc cgatggtgcc cttgcctgtc 2809741 acaacagcct cgtttaagga tgttttctcg cgatcttttt caagcttttc cagatatccc 2809801 gggaaaccaa gcggattttc cgagagcatt ccctgattaa attcctcaaa ggattgttca 2809861 tccatcaagc tttcgatacg ctgttttgcg ttcattggga aatgataatc gcagttcatg 2809921 catacccgca tatttttatc caactcttta gtgagcatga tttttttaca cttaggacat 2809981 tttgtcataa tgccttccgg aacatcgtgc ttcgcttgat cagacggtac ggaagcatac 2810041 tttttctttt tcgtgaatat atcctttaac aaatgattac ctcccttttg tgaagggttc 2810101 tcttcaccgc atgtcatcaa acagatagac ttgctaataa ctttaccgaa actattgtac 2810161 tttttttgtc aaacgctgtc atcctcaatt cgacaacttt ttattcgatg acgtgctcgg 2810221 aaaggcttgt atgaaatcag ataaggtgtt gaaacgacaa ggttgacagc gcattcaaaa 2810281 ataatgttaa acccggctga aattttttta aggctaaccc cctaaaaaaa tttcagccgt 2810341 cagtttaact tgagaacagc gcgccggtct ccgccaacgc gctgccattt ttggaatgaa 2810401 ttaaaattat tcaccaataa tcgtaagttt tcttgttttt tctgcgactt cctcagggtc 2810461 aacagtgatt cttgcaacac ctgtttccat cgcagctttt gccacagcct tcgcaacagc 2810521 aggcgcaaca cgtttatcaa acggtgcagg gatgacatag tctgcgctaa gctcatcttc 2810581 tgaaaccagt gaagcaatgg cttcaaccgc tgcgattttc atttcctcgt taatatgagt 2810641 ggcacgcaca tcaagcgctc cgcggaaaat accagggaat gcaagaacat tgtttacttg 2810701 gttcgggaag tcagaacggc cagttccgac aacgcttgct ccggcttcac gcgcatcttc 2810761 cggcatgatt tccggatttg gatttgccat tgcaaagata atcggatctt ttgccatgct 2810821 ttgaaccatt tcttttgtta acgcgcctgc tacagagaca ccgataaata cgtcagcatc 2810881 aacgataaca tctttcagag aaccgtcttt gcgatcttgg ttcgtgaact tcgccacttc 2810941 atttttgaca tcgttcatgc cgttcgggcg cccttcataa atggcccctt tggaatcgca 2811001 catcacaatg tcgcgaacgc cataatgatg aagaagcttg ataatcgcaa tgccagccgc 2811061 acccgcgccg tttgcgacaa ctttaatgga tgacatggat tttccagaca gtttcagcgc 2811121 gttcacaaga cctgctacgg ttacaatggc agtaccgtgc tgatcatcat ggaaaaccgg 2811181 gatgtttgtt tcttttttga ggcgctcttc aatgataaag cagtttggcg ctgcaatatc 2811241 ttcaaggttg acgccgccaa atgtcggttc cagcaatttt acagtttcaa cgattttatc 2811301 aacatcgttt gtgtttaaag caatcgggaa cgcatctacg cccgcaaagc ttttgaaaag 2811361 aactgctttc ccttccataa caggaagcgc cgcttcaggg ccgatgtttc caaggccaag 2811421 cacagctgta ccgtcagtta caactgctac catgttcccc ttcattgtat aatcatatac 2811481 tttgttaatg tcttcatgaa tatccttaca cggttctgca acacccggag aatacgcgag 2811541 gcttaaatct ttcgcatttc tgacctctac ttttgattta gactccagtt tcccctggtt 2811601 gactttatgc aggtgtaatg cttcttctct taatgacatt ctcctaaaca ctccttatgg 2811661 atattttttg attcgtatac tgctgcgttg attgctgcat tctgcggagt aaatctatct 2811721 gaatatttaa acaggatcac ataattgctc caattgtata acaaaaagcg aatcgttacc 2811781 actgttttaa aacgacgttt ttttgaccca acagctcttt taagcgatat aacacctggt 2811841 gatctgcatt gatatggaac gactcaggta gcttaatcgt ctgtttttgc ctttcataat 2811901 agagataaac gcctgtttcc cctttatgct ccagcaaaat gcgcttaatc tttgccagga 2811961 tctcctggct gtgctgactg ctttctattt ttatataaac cgatggcgct ttttctgcat 2812021 ccatatcttc taataattct gcccgggaca tgatgaattg gatcttatct tgtctaactt 2812081 cacatttccc cgcagtgaac aaaagagcgc cttctcttaa aacgggagaa agctgtctga 2812141 attgttcagg gaagactacg gcttccatct cgccggtttc atcactgagc gttaaaaacg 2812201 ccatgttttg acctgttttc gtccgaatcg ttttgatctt cgacagcaga acgcctagtg 2812261 aaagctgcct tttgactgcc cgctgagcct gcagaatgga gactgctcct tgcgcagtga 2812321 gctgttttcg gaaggcggag aggggatgat ttgaaaaata aatgccaagc gtttcctttt 2812381 caaacgcaag taaatccacc agaggaagct cctccgtctc cacatacttc ggcttaattg 2812441 aaaacgattc atctaaaaac aatcccattt ggtcatcgtc cgcggcgaat agctcagcat 2812501 gttccaaagc aacatcaatg gatgcgagca gcgtggcccg gttttggccg aattcgtcca 2812561 tcgcaccaga aaagataagt gcttcaagca ttttgcgatt tacgcttttt gacggcacgc 2812621 gaaagcagaa atcgaaaaga tcttcaaatg gtttctcttt tcttgcttta tatatatctt 2812681 tgactgctga gacgcctaca ctttttatcg cgcggaggct gtatctgaca gatccgtttt 2812741 caactgtaaa cggaaaactg cttttattca ctgacggagg aaggatacga atcccgctcc 2812801 cctttgcttc gtaaagatat tgagagattt tatcctcatt gccaatgacg cttgtcagca 2812861 atccgcacat aaaatataac ggataatgag ctttcaaata cgcaagctgg cacccgatca 2812921 tgctgtatgc caccgcatgg cttctgttaa agccatagtt tgcgaatttg acgattaaat 2812981 cgtagacctc atttgcagtg tctacagaat actccttttt taagcaccct tcaacaaaat 2813041 ggcttcgctc tctgtccagg atttcttttt tctttttgct gaccgccctt ctcaataggt 2813101 ccgcttcgcc taaagaaaac cccgccatac gggaagcaat catcataatt tgttcctgat 2813161 acacaatgac gccatatgta tcttccaaaa tgctccttaa atcttcatga ggatagtgaa 2813221 caggcgcccg accgtgttta cggtcgataa ataacggaat attttccatc ggacccggcc 2813281 ggtacagtgc attgaccgcc acaatatctt ctaggcccga aggtttcagc cgtttcaaga 2813341 cgcttctcat ccctgcagat tcaagctgga aaatgcctgt cgtatcccct tttgacagca 2813401 aggagaacgt tttgtcatcg ctgtaggaaa tacttgaaag gtctatttta atattttctt 2813461 ctttttcaat cattgaagtg atggattcaa taagtgtcag attcctcaaa cctaagaaat 2813521 ccatttttaa aaggcccaag tcttcaagat ggtccatcgc gtattgcgtt aaatagatcc 2813581 cttcatgccc ttcttgaagc ggaacaacat ctgttaacgg ttcttcactc aggacaacgc 2813641 ccgctgcgtg ggttgatgca tgccttggca gcccttctat tttccgggca attgaataga 2813701 cttgctgaag caggcttgac tcccgaagcc gcttatccag ctgcggtgac tgctgtctcg 2813761 cttcatccag cgtcattccc ggtcttgaag gaatgagttt tgcaagctga tctgcctcct 2813821 tcgggctgac gccgaatact ctgccgacgt cccggagcgc cgcctttgcc gcaagtgttc 2813881 caaaggtgat aatctgtgcg acgtgcattg caccgtattt ctgctgaaca tattgaatga 2813941 cttcatccct tctagtatcg ggaaagtcaa tatcaatatc cggcatgctg acgcgttcgg 2814001 gatttaaaaa tctttcaaac agaaggtgat gcttaatcgg gtcaacatct gtgatataca 2814061 gcacatatgc cacaagagaa cccgccgcag aaccccttcc cggtcctgta acaatccctt 2814121 tttcatgggc gtgcttcata aaatcccaca cgatcagaaa gtaatcgctg aacttcatcc 2814181 gcttgatgac atcaagctca tattgaagac ggcgaaggta tcgttcatca ggcttgccga 2814241 aacggctgcg gagtccctcc atacagatat ccgttaaata atcatcagcg gacgttccgt 2814301 ctggggtcgg aaaagacggt agacgggtct gcccgagact gacgtcaacc cggcattgtt 2814361 ccgcgatctc tacagaagct tgcagtgcct cgggatgctc tcgataaatg ttttgcattt 2814421 cttcgagtgg tttcaaatcg agatcaggca aatcttcagc gggtgcatcc gtcagttttt 2814481 cccccgcttt aatcgctttc aaacaacggt aggcagcctt atcttccttc cttatgtaat 2814541 gcacatcgcc tgtggccgta acagggatac ccgtttcttc tgacagcttt agaatctgct 2814601 cagacaagac ttgattccct ttaaaaggct gataggagaa ataaaaagct ccctttccga 2814661 atatagactg aaattccagc gaggcttgag cagcctgttc gaacagccct ccttcaagaa 2814721 gcgtttcaat atatcctttt tcgccgggcg ttattgcgat aatcccttct cgataactgt 2814781 gaagccattt cggcttcagt ccgccttttg atttagattg cagaacgctg ctgattttca 2814841 gcaggttttg atagcctgta ttcgattttg ccagcaggac gagcgggtat gcttcaagct 2814901 cgctgtcatc tgtaaaaaca gaagccgtca aaccgattat tgggttgatc cctctcgcct 2814961 tgcaagcttt ataaaattga atagctccgt acatgacatg atcatctgtc agcgccaaag 2815021 acgcatatcc gagcctgtca gcttcactga cgagttcttc cacagccgcg gcgctgttta 2815081 gcaggctata cccgctatgc acttgcaggt gaacaaaaga catgctatca cctctttctc 2815141 attacgatcc atttcttcct tcattataag gccggtttcc aaaagaaaca aatgttcttt 2815201 tttgactcat catcatactt gtcctgaaag ctcaatatga tataaaaggt gaggtgataa 2815261 agatggatca ggaagcagga tttatggtga attttatcaa tagctacttc attgcgttag 2815321 gggtgctgat cgggggcgca ctcatcggag ggctcggagc atacttggca ggcgaacccc 2815381 cgcttacagc cattacaaag cttgccaacc ggttaaaaat atgggcgctt gtcgcagcta 2815441 tcggaggcac ctttgatgcg gtatacagct ttgaacgcgg catactcgaa ggcaatacga 2815501 gagatatctt taaacagctt cttttaatta tttcggccat ggggggcgcg caaagcggct 2815561 ggcttattat atcatggctg acccaggagc atctttcttc atgagggtcc cccagcatta 2815621 caaaaaaccg ggatggcagc gttttttcgc gggaatgatg tgcggagccg taatcagctg 2815681 gttctttttc ctgtttactt acggaacatt ccaagaggag caggtcagcc tcatcgaaaa 2815741 gcaaaaagag catgtaaaag acttgaacaa tcaaatttcg atctatcagg aagacctcca 2815801 taaactgaat gaagataata aaagaaaact gctgattcaa agcgtcagcg tcaaattgct 2815861 gaatggggat aaatataaaa tatcacagcc ggataaaacg aaattcgagg agcatgtaaa 2815921 ggatgatatt tcagaggtga ttacaaaaga catagagagc gtctatcaaa caaaggatct 2815981 cttgaagcgg acaattgaaa ataaagtcta tatgatcaat gaaaaaaaat acgaggcaac 2816041 cgtcagagaa ttgattattt atacgaggct gacagtggaa cttgaaattt ctttcgccac 2816101 ataattatgg atttttttta aattctccaa acttctgtcg ctttttccca ttctttttta 2816161 taaactatat gtgaggctta atggcgaaag gaaggaggaa gggaaatgga ggtttacagt 2816221 gaccgtcagt tagcaaaaga tcaagcagcc cgtctcagac aaggtttttc tgcatatgcc 2816281 gaaacaaact cactcgcttc cctcatcaaa aaagaacttc aatcacacaa tctccaagtc 2816341 tacgaggacc ttactgattt cggctgctgg ttcatccccg tcacagatga acactaagag 2816401 agagggtctc ccctctactc gtgttcttta cataatgttt ccagatcagc taaaatacga 2816461 tcagcttcat cccagctgta aatagaggcg cctgaagcta acggatgccc tccgccgtta 2816521 tatttccggg caagtccgtt aatgacaggc cccttcgaac ggaatctgac tctgatttga 2816581 tcgtcttctt ctacgaaaaa cacccaggcg cgaatacctg agatattgcc aagcgtcccg 2816641 acaagctgcg acgcttcaga agccgttgtg ccgaattttt caagcgtatc ctttttgatg 2816701 aaaacagaag ccgccccgtt ttcggacaaa gacacatttt gaaagataaa gccgttaagc 2816761 ttcaccacat tcagttttgt ttcatacaat tgattaaata actctgagga agagaatgga 2816821 tactgaatga gctcgcctgc atattttagt gttttttccg tggtattcgg aaataaaaag 2816881 cgtccggtat ctccaacaat gccggcgtag atcagctctg ccgctttcgt attcagcttc 2816941 cagccgtgct cttttccttc taaatacagc tcgtaaatca tttcacttac tgagctggcg 2817001 cttgtatcga cccagagaag gtcaccgtat ggatcttcgt tcggatggtg gtcgattttc 2817061 attagtttgg cgcctgaagg ataacgctga tcgtcgattc tttcctgatt tgccgtatcg 2817121 cagacaatga caagtgcgcc ttcatatgtt tcattgtcca cctcatcaag ggaatataag 2817181 aaagagaggg acggttcagg cgtgccgacc gcaaaaatat ttttttcagg atatgtttca 2817241 cgcaggattt ccgtaagccc acactgtgat ccgtaggcat ccggatcagg acgcacatgt 2817301 ctatgtaaga taatcgtgtc atataatgat atggttctga tcaattctgt tttcatttga 2817361 tactccttta ttgtttttat tcattaaatc acattctctg ccgacggaaa agaaaaataa 2817421 cgtcaaaacc aagcccgttt ttgtataaaa tggggttgta aacttttacg atggaggatt 2817481 tcatttatgc tggttcttgt ttttttgatt gggctttcag cctgctttta tgtgtactat 2817541 aaagtaaaag gcgtacgggc aaagccatct ttggcaaaag aaatatgttc agcaaaatca 2817601 agcatggcct tagggtcact agtcctgttc tacgggctta accaaatgat attattccat 2817661 tcagtattaa cgttagtaat cggcggtatc tttatcgtca taggagcagg aagcgcttgg 2817721 gcaggttata aagccttcag gcattacaat ccccttcacg ccaaagaagc tgaaagagat 2817781 cacgcgtaag gggcgcctga acgtccctta gcttctttcc atcagctgaa ccatcagcat 2817841 cgctttagac acgatatgac cttggctgtg cacttccact tccattttcc caaactttct 2817901 gccggcctcc aagatgcgag gtttgacttc gatgactgat tccatctgca caggcttcaa 2817961 aaagaagatg gtgatgctct ctatgacgag ttcgccgcgt tttttcgagc gcaaaaatcg 2818021 gtttgccgct tgcgtcaaaa tggtcgtaaa tacgccataa gaaatggttc caagctgatt 2818081 tgtcatttgc ggcgtgactt catactcgta aaccgtttga tcttctttat catcaccctc 2818141 atctttaaac ccccttgaaa cgatatcatc aagcttctcc ccgacctgcg gctgcttttg 2818201 aatcatttga agagctttca atacgtcttg gcggctgatc atgccgatga gtttttggtg 2818261 gccgtcagtg acgggaagca cttcgatccc ttcccatacc atcatttgcg cagctgaagc 2818321 gacagatgtt ttcccaataa ccgtgacggg atttttggtc atgacttttt ctatagatgc 2818381 atttcggtca tggccagcaa tatcttttga tgtcagaatg ccatggattt tcatttgatc 2818441 gtcgacaacc gggaagcggc cgtgccccgt ttcaaaattt ttctcatacc atttttcaag 2818501 tttatcctta ggcgaaagat ataccgtgcg gtcagcaggt gttaggatgt cctccaccaa 2818561 aacaatttct tttttgatca gctggtcata tattgcccgg ttaatcatcg cggcaactgt 2818621 aaaggtgtca tagctcgtgg ataaaatcgg cagttcaagc tcatctgcca gctgcacaat 2818681 gctgtcatcc gtgttaaagc ccccggtcac caatacggcc gcgcccgctt caagcgcctg 2818741 cctgtgtgca ttgattctgt ttccgacaat caaaagattc cccgctgcgg tgtaacgcat 2818801 catcgcgtca agctccatcg cgccgatgac gaatttattc aatgtcttat ggagccctgc 2818861 cctgcctccg agcacttgtc cgtctataac atttacaacc tctgcatagg taagcttttc 2818921 aatgttctct tttttctttt gttcaattct gattgtgccc acacgttcaa tcgtgctgac 2818981 aaacccttta ttctctgctt ccttgatcgc tctgtacgcg gttccttcgc ttactttcat 2819041 ttcctttgca attcttcgga cagaaatttt ttcaccgaca ggcagtgaat cgatatacgt 2819101 taaaatttgt tcatgcttcg ttgccaagcc tttcacctct aaggacagtc ttcttgtttt 2819161 tattataagg tttcaaagga tttatacgca atgaggctgg aaaataaaaa agaagcccga 2819221 ccggcttctt acagcgttga tttcgttcca gtcaaacgca aggaccacgt gattcctttt 2819281 acatcgtaaa gcggaaaaac ctttattttt cttttaaatg gacatcaacc gctgtcttaa 2819341 caatatttcg attccctatt ttagataaaa caaataaaac tgcggatagc catatcgccc 2819401 ctatggccgt atagatcaat ggatgaacag ctgtgtttgc gatccattca tttattaatg 2819461 ttctggcatt taccagaata ataaatcctc ctacaagcac acccatcaat tgcggatgaa 2819521 acttctgcac cagccatgct gcgatagggg cagcgataat tccgccggcc attagtgaaa 2819581 acacccataa ccaattgacg tcctcccatc ctaatgaaat aagaaaaccg gcggttgcag 2819641 atacggcgat ggcaaattca cttgtgtcta cagtcccgac aactttcctc gggctcaagc 2819701 ctttgcggga taataaaatc ggagtggtca ccggtcccca gccgcctccg cctgtggcat 2819761 ctgcaaaacc agcgatcact cccaatggga tggattgttt tcggtttaac ggcacatgct 2819821 tcttctcaag agccggctta tattgaaata aaaacctgat caatacatat ccgcccagaa 2819881 ggagcaaaaa caaagaaata tagggtttcg ccacatctcc aggtaattgg ctgaggaatg 2819941 ccgcgcctaa aaaagcgcct atagagccgg gaatgacaag ctgataaacg gtttgtttgt 2820001 caacattgcc aaatttaata tgcgacactc ccgatgcggc agtcgttacg acttccgcta 2820061 aatggacaga agccgaagcc acagcaggtg tgatgccaaa cgccaataac aaagaagttg 2820121 aggtaacccc ataagccata cctaacgaac cgtctattaa ctgcgacaat aaaccaataa 2820181 atgcaaaaac gattaatttc ttcatcagaa caccccatct atatcaatca gatatttttg 2820241 actcttcatt cgaatctaac aatctcttgg cgctttcata taaaaaataa gaggctttga 2820301 taattgcagt ttcatctatt gtaaatgcag ggtggtgcca atcatgatca ccgtctgttc 2820361 caaaaaacgc aaaggatccc ggaatatgct caagataata agcaaaatct tcccccgcgg 2820421 ttgatggggc gggatcaatg acttgaagtt tcgctttatg tgcagcgtct cgcaccagcc 2820481 ccgtaattgc ctcatcatta caaagcggcg gcggtccgga atgccacttc acatttgcct 2820541 ttaacgagaa agcggcagaa atctgctctg tgactgcaaa aaaacgctgt ttcacttgat 2820601 tacgaacctc tgaatcaaat gtacgaacag tgccctcaat gaccactgta tccggaatga 2820661 cattccaagt gctgccgccg ttgattttcc ctacggttaa aatcgcgctt tgcagcgggt 2820721 ttacatttct gcttacaatc gtttgcaggg cgacaataag ctgagaggcg ccgataattg 2820781 gatcaaaacc attatgcggc aatgctgcat gagcaccttt cccttctatc tctactttaa 2820841 atcggtcaac agcagccata agcgggcctg tttttaaccc tacagtccca accgcgatat 2820901 ccggtttatt gtgaaggcca ataaccgcat caatgccatc cagttggccg tcctctatca 2820961 cttttgtagc gcctgcaccc gcttcctctg ctggctgaaa taataaacga atctttcctt 2821021 tcagactgtc ttgattttcc ttcaataaaa aggccgcacc aagaagcgct gccgtatgaa 2821081 aatcatgacc gcacgcatgc atgatccctt tatgtttaga cgcataaggc aatcctgttt 2821141 tttcttcaat tggcaaggcg tcaatatcag ccctcaaagc aatcgccgga ccttctgact 2821201 cccctgctat gtctgcgaac acacccgttt ttagagcagt agggcgaatc tgtatcccct 2821261 tttctttaag gcattttttt ataaaagcag ttgtttcaaa ttcttctttt gacagttcag 2821321 gatattggtg caggtgccgg cgaatgccga tgagctgctt ttctagcgtt gagagattta 2821381 cgggattaga ctcctctttc aacgtcagga tgtcatttcc tgtagtctga tatggatagg 2821441 agccttctat atttctccaa taatccaaag acatatgttc cgctcctttc cctatcccaa 2821501 tatattttct tcagactctt caacataaga tgaaataaat cggttcaatt tatcagcaag 2821561 accgcccgcc ccaaatctta tatacttgct ggaaactttc ggattatctt ctttcaaaaa 2821621 gcttaaaaaa gataaaatat aaatgcgcct gtaagctact tgtgtaattc cgtactcaaa 2821681 aaaccagtta tcaatgacat tgtatacgcc tcggttgacg ccatataggt tattacattt 2821741 cttgtaaaag cagagatccg gaagatttaa ctcctgatgg gaaagaaggc tttctttttt 2821801 gtttggtgcc ataatcccaa tcagctcaaa gcgttttgca acgcacgaaa tatccttttt 2821861 aatttgcttt gttaaagact ccaaagaatc aaaccttctt tcttctctaa ttttaaagag 2821921 aatgctgcat tcgatttttt ctccataaat gtctctatga aagtcaaaca aaaaaatctc 2821981 caatgtcttt tcaaggttag agcccaccgt cggtttcaca ccgatattca taacccctaa 2822041 atgaaattga tgattgactg tcgccagaac cccataaact ccattacgca gcccatgtat 2822101 ttttgcatct acatttgccg tggggaatcc aagctttctg cctaattgtt ttcctttcac 2822161 aaccgtaccg gcaatgatcg tcaaaaaagt cagcctcctc tctcagcttc cgcattcgat 2822221 cagacgaaac ctaatgatgt gatgaatgta aaacggattg atgctgcgga atgccaagac 2822281 cgagattttc ccgcaatgtc ccgccgcgat aatcttgacg ataaagccct ctttcttgaa 2822341 gaatcggaat caccttttct acaaaagcat caagtgttcc cggtatatcc gacccaacga 2822401 taaacccatc cgccgcctca gcgttgaacc aagtttcaat taaggatgcg acacgctctg 2822461 gtgttccgat gaatagagtc cgtggaaaag ccatttcctg tgctacctcc cgcaatgtca 2822521 gatttctggc ttttgcttct ctcttaatcc ggtctgttgt gctttgaaac gcattctttc 2822581 ccacatcgcc aatatcggga aatggctcat ccaacgggta aacactcaga tcataatcat 2822641 caaaaaaacg ggccaaataa gtaacagcat tttcaatcgg tatcaattct gcaaattcac 2822701 gatacttctt ttccgcctct tcttccgtat ctgccacaat cgggctgatc cctggaaaaa 2822761 tccgcacact tgaaggatca cgcccttcat cagcagctcg gcttttcaca tccgcataaa 2822821 acgcttttgt ctcttctaat gaattggaat gggtaaaaat cgcatccgca tttttagcag 2822881 caaactgccg gcctgtttct gatgaacccg cttgaaacac tacaggctct ccctgcttag 2822941 agcgcccgat attcaagggc ccctctactt gaaaatactt tcctttatga ttcaggcgat 2823001 gaagcttcgc ctgatcgaaa aactgccctg ttttcttatt gtgtataaat gcgtcatgct 2823061 cccaggaatt ccacagcccg cgcacaacat ccaaatgctc ttgtgcgatc tcgtaacgtt 2823121 cagtgtgttc tggcaaatta gacttactat ggttgcgcgc cgctccttcc tgcggcgaag 2823181 taaccagatt ccagccggcc ctgcccccgc tgatatggtc cagcgacatc aattgtctgg 2823241 agatagtgaa tggctcagta aaagatgtag agaacgtccc tactaaacca atatttttgg 2823301 taaccgatgc cagcgcagat aaaatggtga tcggttcaaa acggtttaaa aaatgaggaa 2823361 tcgatttttc agaaataaat aagccgtctg caatgaaaat aaaactaaac aaaccttttt 2823421 cagctgtttg cgcctttttc atgtaaaatt caatattcgt gctggccgag ggatcaacat 2823481 cgggatgacg ccagccgtca gttgttcccc cgacaccgtg aatcatggct ccaaactgaa 2823541 taaaatctgc acgtgtcatc tttttgcctc ctttatctgt gcatgattag caagtgcaag 2823601 atcaaggtgt tcaatgccga tttcagttat cccttgatac tgattgccgc gcccgatttc 2823661 gaccacaggc acatggcgca ccccatattt cacctgtaaa atatcccgaa gcttttcttt 2823721 ctctgaaaca tcgatatttt ggaacgggaa ccctttttca ttcaaataat tcttgacttc 2823781 ctcacaatac gaacagcctt ttttactcca aaccacaatg ttcacaacat cactcattct 2823841 tctgtccctc cttaacgttt tgcagctaaa actgcatcgc tcagcagctg ataagacagc 2823901 tgtttttcta cagcattttt gatcggtgta aaaataacaa aatcattgat tttgtatgtg 2823961 cctgataaac gtgttaattc ttctgccact tcttcctttg ttccggcaat aatcccggtt 2824021 ttttgcacga tgatgtcata gggctctgtg acgttttcca gataggcctc agcctgttcg 2824081 cgggaaccga cgttgacctt acgcccgtct ttcaaaacca cttttatcga ttcacgcgac 2824141 acaatatgtt tttccgcttc ttcttttgta tgtgccgcaa aaacagcggg ggcaagatga 2824201 aattcagcct cagatcctgg cgggagatgc gcgtcaaatg ctcggcgggc ttccttcagc 2824261 acttcctctt caccgttaat aaagtaagca aagacaaaag agattcccag ttttgcagca 2824321 gaaatggcac tctctgtgct tcctcccaat agaaaaatac ccggcttccg atcaacctgc 2824381 ggcctaggac gcaatgcggc atagcggtgg gtatcaggaa aatcatcccg aacgaaatga 2824441 gtaagctcct ccagtttttc atcaaactga cgcaccggtt ttttatattc ggcctgcagc 2824501 gcgtctgtgg acagctgaaa cccgccgggc gctttgccca ctccaagatc tatacggccg 2824561 ggagctaacg ctgatagaag atggaattgc tccgctactt tataagagct gtaatgctgc 2824621 agcatcactc cgcctgatgc taaacgaatt tttcttgtgc ttgcagcaag atagcctaaa 2824681 agaacctcgg gtgcagaccc tgcaatctca tcattgttgt gatgttcggc cacccaaaat 2824741 cggtgatatc cacattcttc agccatttgt gccaatttca ctgtatgctg taatgtatca 2824801 gctgctgtct ccccttcacc aatcaagctt tggtctaaaa tacttaagcg gatcatatca 2824861 ccggctcctt tatgtgttct tttggttcaa ataaatattc cggcgaaaca cggcggagaa 2824921 actgcctcgt tctgtctttt ttggtatggc ggaagacttc ctccggggtt ccttgttcaa 2824981 caatgactcc ttcatccata aaaacaactt gatcagagac ccttcttgca aactccattt 2825041 catgtgtaac aacaatcatg gtggctccgg ttttcacgat ttccagcatt acctcaagca 2825101 cttcaccgac cagctccggg tcaagcgctg ccgtcggctc atcgaacagc agcacatcag 2825161 gatgaatggc aagcgccctt gctatcccta ccctctgctt ttgtcctccc gataactgac 2825221 tcggataagc gttcaattta tcttgaagcc cgacctttct cagttcattt tccgctacgg 2825281 catacgcgtc ttgttttctc attttccggg caatcgtcaa gccctccatg acattttcaa 2825341 tcaccgtttt gtgagcaaac aggtggtatt gctgaaatac cattgccgtc tgttttctga 2825401 gccagtgaac ctcttttttg gacggaaagc ggcaattaat cactttgtca tgtatagaaa 2825461 tgatcccttc gtctggacgt tctaataaat tcaggcaccg taaaaaggtg gttttccctg 2825521 atccgctcgg cccgataatc gtcacaactt ctcccttgcg taccgtgaga tttatccctt 2825581 ttaatacatg gtggatgcca aactgtttat ggatattttt aatctcaatc ataaagtgcc 2825641 tccttgaaat ctggctgcct ttctctctaa tactccattt gcggattcta ggattagagt 2825701 cagcacccaa tagataatcg ctgctccgat aaacgcttct aaaaatgcat aattatcaga 2825761 agcaacgata gtcgccgtcc ctgtaatctc tgggacagcc actatagccg cgatagaggt 2825821 ggtatgcaaa aagccgatac ccaaatttgt gaagtttggg atggaaacct tcagcgcctg 2825881 cggcaatatt acacgccgaa aggtttggct gtatgtcaag ccgattgaat aagccgcttc 2825941 gacctgtccg gtatccatcg ccagaatgcc cgaccggatg atttctgtga gataagctcc 2826001 ggcagttaaa gacaaggcca tgatgacaaa catggagacc ggtatctcat tagcggacca 2826061 gccgagatga aaaaaactgc tgacttgatc tgcaacaggc ggtatcccta aataaatcaa 2826121 cataatgtga agaattgcag gtgtacttcg aaagaaagac acataaaacc ttgagcaagc 2826181 caccaagccc ttaattctaa aaattctaac aattatattt ccaagagcca cgagaaatcc 2826241 aaacacaatc ggcaaaacag ccatcatcaa tgtcagagga atggtcttta ccatttcttt 2826301 catggcggaa acgataaatg gaaagtcaaa ttgcaatctt ctcccccctc atccgaagaa 2826361 atatatcaat gtatgttcat gtcaaaaaca gtaacaatcc ttgtttgatt cttcttgatt 2826421 cgtttttctg ccactcgaaa gaaccattcg aataaaaccg ctacagcata ataaacaatc 2826481 gatagcgcaa tgtaaacttc aagagaatgg ttgcttgagg taatcagtgt ttggcccctt 2826541 ccggacatat ccataacacc tattgaaaag gctagagacg tatcttttaa agaactgatc 2826601 accatgtttc ccatattcgg aaacgcctgg acaagtgcct ggggcagaac gattcgcctg 2826661 aaggcctgac taccgcttaa gccaatactg tacgccgctt ccgtttggcc tttatctaca 2826721 ctgcccaccc ccgctcgaat gatttctgcg gctgccgctg cattgcttaa cgcgtaggtt 2826781 gcgacagcag cataaaacgg gtccattttt gatgtatcaa tcccgataag ccccgtaagc 2826841 gccgggatcc cgtaaaacac gatgaaaagc tgcaccatga taggcgttcc cctgaaaaac 2826901 gagatataca cttttgccaa ttgatttaca attggaatat tatagatgcg gggcagtgcc 2826961 agaaagagtc ctaatacaaa accgaaaagc aaggacagtg ttaaaatgta taatgtaacc 2827021 ggtaaataag cggttaacgt cggcacaaaa tctccaatca tgttcatatc aaacgctttt 2827081 tccatcactg ctccctctct ttttacctaa tactgctctt tggaatagtc gtcaccaagc 2827141 catttcaaac tgagcctttt caacgttccg tcatcaatga tttcctgtaa ggctttatca 2827201 atatcgtcac ttaacgtttg ttcatttttg ttaaacataa aatacacttt ggcatttgaa 2827261 agcacattac cgacggtttt ttctttaata gtgctcgtct tgttttgaaa gtctactgca 2827321 aaaggcgttg agatcgttgc gtccgcacgc cccgatttca gctgattcgc agtctcattt 2827381 gcgccttggc cctcataggc aatctcaaac ggccgtccat tatcctcatt ccattttttc 2827441 agtacaagcg ctccgttgga ggttgcactc gtaatcaccc gttttccttt taagtcttca 2827501 attccacgga tcgtatcgtt attttgaagc acagtaattt ttaaaggaaa atggttgtaa 2827561 gcaaccttgt taaacagaaa ttttttctca cgctctttgc ttttctccat ttgatgtgcc 2827621 acgatatcga ctttatgctg tccgaggctg acaagcaggt tggaaaattc catcgtttta 2827681 aatgtgaatt tataatgtgg caggcgctta tcaagctctt tgatcagttc gacatcataa 2827741 ccggttaaat cgcctttttc atcgataaag caaatattcg gaaattgggt tccagttccg 2827801 accgtgatcg tctgtacctt cttttgcccg gctcccgtcg tttgactgcc tgcaccgcaa 2827861 gctgacagaa ctgttataag cgaaaataat attgccatga atgctgtttt cgttttcatc 2827921 tcatcgcccc atttattttt caaaacttga ttttgaataa tctgccccga gccattttcg 2827981 gcttagtttt tttagcgttc cgtttttctc cagcttttta atcgcttgat ccgtgtcatc 2828041 cgccaaggtt tggctgcctt tattaaacat aaagtacacc tcggtatcta ataacacgtc 2828101 accgactgtc ttttggcgga aggcgtgcgt tttattctga aaatcgacgg caaacggtgt 2828161 agctatcgtt gcatctgcgc gcccggtttc aatttgattg gcggtatcat tgcttccctg 2828221 tcccgcatat ttcaaatgaa ttgggctgcc gtgcgttttg ttgtactttg taatataatc 2828281 tgccgcattt gacgtggcgc caactatgac tgtttttccg tgtaagtctt ttaatgtatg 2828341 aatcttgtga ttatcctctt tcaccgtgat gtacatcggc gagtagttat atgggacttt 2828401 atgatacaaa aaacgctttt ctcgttcttt atttttggcc atattgtgcg caatcacatc 2828461 aattttttta tttccgagac tcgtcagcaa atttgagaaa tccatcgttt taaattcaaa 2828521 tgtatattga ggcaactcct tatcgatggc tttcatcact tcaatgtcat acccggtcaa 2828581 ttcacctttt tcatttaaaa acgcaatatt cggaaaatct gttccagtgc cgactatgac 2828641 cgtttgagcc tgacgatctg ttttgttatt tgtttgcgaa catcccccgc caagtaatgc 2828701 aaacactgac agcagcaaaa ccaatccttt acgcttattc ataggctgcc tcacatcatg 2828761 cccagctggg cgcacctaaa agcgttgggt taaatcgttc cggaatcaga accttgtgca 2828821 tcatcacacc tatgtccccg tctttttcct gctcaaaata cacttcatac cctctccttc 2828881 tgtacatgtc agcaagccaa ggatgcttgc gcgccgatgt gccgagtgtc agcgcaggag 2828941 ccttcagcat atctcgaagc actttttctt caacatacgt aagcagctta cttccggcgc 2829001 cttgcccttt atattccggc agtgtcgcaa accaccacac aaatggatat tttgaaggag 2829061 gcgtctcact ctcccacggg aacctgattg taatcgttga aatcagcttc ccatcccgct 2829121 ccagcacaat cgctgaatga tgttcaatat tttctgatac catttggata tcagctctcg 2829181 tggatggcca atcaatatcc agctgccgaa tgggctgaaa tgcgctgtta accagtttca 2829241 acagctccga tgcatcttca acagttgcca gtcgaaaaat atcatcactc atttttgtca 2829301 ctcctcttca caaaatatat aattcctatt tgtttactaa gcttttattg tttatactat 2829361 aaagcatact ctgatctttg actaatcaaa aaaagtaaac cttcacttca gtaattttaa 2829421 tgatgaaaaa caggagggag cacattggag ttacgctcaa tcaaaacgtt tcatacgatt 2829481 gtaaaatttg gaagcttcta taaagctgca gaaatactca actactcgca gccgacgata 2829541 tcgatgcgta tgaagcaatt ggagcaggat ttaggcgtac tgctgtttga aagaggaaaa 2829601 agcctgcagt tgacaaaagc agggaagctt ttttatgaac gaacaggaga tcttttgatg 2829661 caatacgagg cgcttaaaca caacctctcc gacttaaagg aagaagaggc aggcattatc 2829721 aacatagggg tttcagagcc aaccgccagt ctgatattcc ccgagatttt aaaggatttc 2829781 ttaatggatt acccaaagat aacggttaat atcaaggttg atgacgccaa tacctgcagt 2829841 caaaagctct tagacgggac gattgatttt gcagtctgcg gcgagccgga gctgattctt 2829901 gaaaattact accatccatt tttttatgac acattaaatg tgattgtatc tgatcaacat 2829961 ccgctcgctg agaagaaggc tgtccatttg tctgatttag cagaagagcg cttcatattt 2830021 acgcccgcca attgccccat tcgcttacaa attgaacagc atttacatag agaactcggg 2830081 aatcgctaca aaaaaatgga gctcacaagc agcatgtcac atgaatatta cgtacgtgaa 2830141 aacatcggaa tttcaatctt taccagcacc gcacattcta aaccgttcaa cggcactaaa 2830201 gtcattccaa ttctgaacct ggatatcacc ccgcccatag ggctgttgac aaatcaaaaa 2830261 gaagttcatt ttgaccgcgc cacgaaggac ttgatcgccc ggataaccaa acgttttcag 2830321 cagcgcagca aagaattgga aggaacctct gataagacca ttacaggata actgaaaaaa 2830381 taaaaaccac ctcctgattc atcaggagat ggtttcacgg tttaaagctc gatcgtctca 2830441 ccgaccgaca tgactttgcc gactccgccc ggcaggctgt cagcgaatgc ttctgggtct 2830501 tgttcgatga ccgggaatgt attgtaatgc accggcacga cctgttttgc gcgcagccat 2830561 tcagcagcaa gcttggcgtc ttcaggcccc attgtaaagt tatcgccaat cggaaggaaa 2830621 gcaaggtcga tatgattcaa ttcgccaatg agtttcatat cagagaaaag tgccgtatcg 2830681 cccgcgtgga aaatcgtttt atcttctaca gtcagcaaaa taccggcagg catgcctgtg 2830741 taagtgatcg ttttgttttc ttcatctgtg atggctgatc catgaaaggc ctgtgtgagc 2830801 ttcacttttc caaaatcgaa ctggcgggag ccgccaatat gcattggatg aacattcaag 2830861 cctttccagc ctaagtacac agcgagctcg ttcggggcta taaccagcgc gttattttgc 2830921 ttggcgattt gttcagtatc accgacatgg tcattgtggc cgtgcgttag taagatgaca 2830981 tccgctttta catcctccgg ctttatatcc gttaatgaat tccctgttaa aaacggatca 2831041 aaaataatat gatggtcctt cgtttccact gtgattacag aatgtccgtg atatgtcact 2831101 ttcatttctt tcacctcgtc acatgatttt gtttttttta ttttcccttt ttaaaaagct 2831161 gaaaaactta tgttgtttga ttcttgttaa tgacattgag gcctccggtg gcttcaatga 2831221 cagtccctgt cacaaggtct gagttctcct cacacaagaa agcgataatc ctggcaatat 2831281 cctcgcctgt accggatctt cctatcggcg ttttttcttt gccgattcgc attctggctt 2831341 cctctatcga tgcttctttc atgtcgccga caatgtctcc tgggcaaacc atgttggcgg 2831401 ttatgccgaa ttcggcttct tcaatggcaa ttgtcttcgt caaagaagcc aagcccactt 2831461 tcgcagcgcc aaatgccgat cggtgaagcc agccgggcgc gtgagccgca ccttggaatc 2831521 cgtacgtaat aatgcgtcca aattgctgtt ttctcataat aggaataacc gctttgaata 2831581 aatgaaagac ggcgcttaaa tttccttcca gcatgccata ccattcatca tcagtataat 2831641 cggctaactt tttacgttca aatatgtatg gtccagcgtt gttaatcaaa aagtcgatcc 2831701 ttccgaagcg gtttaaggca gcctctgcaa tacgcagcag atcttctttt ttggtgacat 2831761 caccttttac aaattgcagc cggtcaagac aatcgggaca ggcttccttc aggcggctga 2831821 ctgcctcctc atcctgtctg taattgactg ttactgaata cccctttgca agcaacgttt 2831881 cagtcacttt gcggcctaaa cccttcgaac cggcagtaat taaagcatgt cgcacatgaa 2831941 tacctcccaa agcaacgtcg ccgctttcaa taaagtgttt cttcttctac tttactataa 2832001 aaggcttgca atatcacttt ttacactttg gcatacaaaa aaagctgcct gtacagacag 2832061 cttattctgc aggagatgaa gactcctgat caggcatatc gacataaccg ctttgatatg 2832121 cttctgaaat gagccttgtt gtctcctggc tttcttgttc atcataaata tagcgttccg 2832181 gttctttttt catcattctg cctcccatca ttatagaggt aggttggcta taatgacggg 2832241 attttatgaa ggaaatttta acaaactcct gctgccacgc aagctttcgc tttttcaagc 2832301 gcctgttcca cctgtttgaa tccggtgccc ccggcgctca ttcttttttc aactgcgtag 2832361 taagggtcta acacagtgta aatatcttct tcaaatagtg tgctcgcctg ctgaaactcg 2832421 ccaaacggca tatcgcttaa atagatccct ctttcgatgc atgtgtacac aagtttcccg 2832481 accacttcat gcgcttctct gaacggcatt ccttttttag ctaaataatc ggccagttcc 2832541 gtcgcgtttg aaaagtcttg ttttgttgct tgcttcatga cgtctttgtt tacagtcatt 2832601 gtttggatca tgcctgtgaa gatttgcagg ctgccctcca ccgttttcac cgtgtcaaac 2832661 atgccctctt tgtcttcctg cagatctttg ttgtaagcga gcggaagtcc tttcatgatc 2832721 gtaaacagcc ccatcatatc gccgtatacg cgtcctgttt tgccgcggat cagctccgcc 2832781 atatcagggt ttttcttttg cggcatcatg ctgcttcctg ttgcgtacgt atcgtcaagc 2832841 tcgatgaatt taaactcctg cgagcaccat aaaatgattt cttcagagaa acgggatagg 2832901 tgcatcatca gcatactgct gttgcttaaa aactccaaaa tgaagtctct gtcgctgacg 2832961 ccgtccaagc tgttttcata aatggcatca aagccgagca gttccgctga ataatcacgg 2833021 tcaattggga aggttgttcc cgcgagcgcc ccgcagccga gcggagattt gttaatccgc 2833081 ttcattgaat cctgaaaacg ctccttgtcg cgctcaagca tccagaaata cgcaagcaga 2833141 tggtgagcga atgaaatcgg ctgggcgcgc tgcaaatgtg tgtagcccgg cagaatcgtt 2833201 tcaacgttcg cttccgcctt ttcaatcagc gcactttgga atgcctcaat cagctcgatg 2833261 atgtggccga catgattctt caagtataaa tgcatgtcag tcgccacctg gtcattccgg 2833321 cttctgccgg tatgcagctt gccgccaaga ggaccgattt cgtcaatgag cattttctca 2833381 atgttcaaat gaatatcctc ataatcgact gagaattcca atgctccctc ctctgctttt 2833441 tgcaaaaggg tattcaggcc ctctcggatt ttcaactctt cttctgctgt cagaataccg 2833501 cattttttca gcatggcagc atgtgcgaga gaccctgtaa tgtcttcagc aactaaattt 2833561 tggtcaaatg atatggacgc gccgaactcg tcgacccatt tttccggtgt tttttgaaat 2833621 cggcctcccc aaagcttctt catgctttaa tctgctcctt ctttttcacg atgctgttca 2833681 cttttgtcgg aagtccccaa agctcgataa atccgattgc tgcatggtga tcaaatgcat 2833741 cgtcttttgt atatgttgca agtttttcat catatagaga gtattccgat ttacgtcctt 2833801 ctacaattgc atggccttta aacagcttca cgcggacaat gcctgtgaca tgcttttgcg 2833861 tttcttttaa gaaagcgtgc agcgcgtctt ttaacggtga gaaccataag ccgttgtaaa 2833921 tgatttctga cattttttgc tcgatgatcg gtttaaagtg ggctacctct ttcaccagtg 2833981 tcaaatcttc taattcttta tgcgctttga tcagtgtcat cgcaccaggg cattcgtata 2834041 cttcccggga tttaatgccg acgaggcggt tttccacgtg gtcgatacgt ccgacaccgt 2834101 gcgcgcccgc catttcattc agcttcaaga tcagctcaga aagcgagtag gaaacaccgt 2834161 caatggagac aggcacgccc tgttcaaatg caatttcaat cacttccggc gtgtccggcg 2834221 ttttttccag cggagctgtt aaatcgtatg caccttctgg cggcgccgcc catggatctt 2834281 ctaaaatgcc gcactcattg gcgcgtcccc agaggttttg gtcgatagaa tacgggctgt 2834341 caagattgat cggaatcgga atgccgcggc tagccgcata ttcaatttct tcttcacgtg 2834401 accactgcca ttcgcgaacc ggcgcgatga cttctaggtc agggtttaat gatttaatgg 2834461 agacttcgaa acgaacctgg tcatttcctt tccctgtgca tccgtgggca atcgcctgtg 2834521 catcttcttt ttccgcaatt tcaaccagtt ttttcgcgat cagcggtcga gataatgccg 2834581 aaacaagcgg gtattttcct tcatacattg tgtgggcctg caaagagata agcgcgtaat 2834641 cctgtgcaaa ttcttctttt gcatcgatca cgtaggagtt tgtcgcgccg acttcaagcg 2834701 ctttctgctg aacaaatgcc aaatctttgc cctcaccgac atccaggcag caggcgatta 2834761 cattatatcc ttgctcctga agccatttta ttgcgacgga agtatcaaga cctcctgagt 2834821 atgctaatac gacttttttc tgttctgaca tgataaaaat cccctctcaa ccgtgtttct 2834881 attttgtata aaaataaatt atatttaata aaaatacatt ttgtatgtat acactttaac 2834941 aagtacgttt cgttttttca agccttttat aaaaaaaact tcacctaaat ttcaggtgaa 2835001 gtttcatagt atttattcat ttacttgtct tttctgattt ctctgaccac atgcgcaagt 2835061 tcgggaataa tcagcttatt cattgccagc tttactgcgc cgcttgagcc tggcgttgag 2835121 aaaacagcgg tatgctgaat gacgccggca gttgctctcg acatgattgc ggcagagccg 2835181 atatcctctg tataactcag catcctgaat atttctccaa agccgggcag ttctttcgaa 2835241 aacagcggcg ttatggcttc aattgtgaca tcccgatctg ctatgcctgt ccctccgttt 2835301 aagagtaccg cgtctgtctg ttcatccatg cagcccgcaa gcactgaccg ttgcaaagca 2835361 tccttttcgt cttttacaat ttcatatgcg gcaatatgat gaccggcttc ttctaaaaat 2835421 gagatcatca gcttgccgct tttatcggtt tcatctgtcc tcgtgtcact gacagtaatc 2835481 actttgcacc gaacgatatc gggagcttct tgtttatgct cttgaacgct cattggccca 2835541 cctcttttat gttttctgtc tgtcactatc atgcatcaac aaaaaagcac attcaagaga 2835601 atgtgctttc atgcgattta ttttgctaaa cgaacaacgt cgcgcgcaat catgacttct 2835661 tcatcagtcg ggatgatcat gacttttact ggagaatgcg gatagctgat gaaagcttcc 2835721 tcgccgcgca cgttattaag cgcagggtcc cagtatacgc ccatgaattc taaaccgcga 2835781 agaacgcgtt ctctgacttc cacactgttt tcaccgatac cggcagtaaa gatgatcgca 2835841 tctacaccgc tcattcttgc agcgtaagaa ccgatgtatt tgtggattct gcttgcgaat 2835901 acttcaagag ccgtttccgc gcgctcattt ccttctttcg tagcttcaac gatgtcacga 2835961 agatcgcttg agaaaccgga aatgccgagc agtccgcttt ttttgtttaa tgtattcagt 2836021 acttcgtcag ccgtttggcc tgttttctcc atgatgtatg ggatcagggc agggtcgatg 2836081 tttccagagc gtgtgcccat tgctacaccg gcaagcggcg taaagcccat ggatgtgtca 2836141 atagattttc cgccttcaac agcggcaata cttgctccgt ttccaaggtg gcaggaaatc 2836201 aggcgcaagt cttttaacgg acggccgaga agctctgccg cacgctcagt tacatattta 2836261 tgtgaagtgc cgtggaagcc gtatttacgg atgccgaatt tttcatagta ttcatacggc 2836321 aagctgtaaa ggtaagactg ctcaggcatt gtttggtgga atgctgtatc aaatacagct 2836381 accgcaggaa catttggaag cacttctttg aacgctttaa ttccaacgat atttgccgga 2836441 ttgtgaagcg gtgccaattc agaaatatct tcgatttcct taatggtttc atccgttaat 2836501 aaaacagaat cgctgaattt ttctccgccg tgaacgacac gatggccaat tccgtcaatt 2836561 tcattcaagt ctttaataat gccgaattcc gttaacttat tcagcagcat tttaacagct 2836621 accgcatgat ctggaatatc agttacttct gtattttttt cgccgttcac agaaattgtg 2836681 aatacgctgt cggcgatacc gattcgttca actaaaccct tcgttaaaac ggtttctgaa 2836741 ggcatttcga aaagctgaaa tttcaaagac gagcttcctg cgttaattgc aataattttg 2836801 gacatgattg acgctccttt atactctgta tcaacaactt cgtttttcgt acttttttcc 2836861 cggtgaatat caacatcttc tccgaaaaat atctgacttt tccatttaaa cattgtcatg 2836921 tcggcttttc aagtcaactt gcgtattgat aacgcttaca ataagaagtc gttattttca 2836981 gacacattca ctataggttt tgtattgatg aacgcttaca atttgcggtt tttccctctg 2837041 tattttgtgt ttcaaagctg gattcaattc gtcaagtccg gtcttcaaaa gcataaataa 2837101 aagcagctta ggcatcgacc tcatacggct gtctaagctg cttttaaaac acttactttt 2837161 cttttttaaa ccattcatca aattgagcca tcatatcaag catcgccttt tgattggaga 2837221 aagacggaag attcgcaagc agaatttgcc ccggcgcttt cgtattctct ccttgtttct 2837281 gaagcacaag gatgcttttg gcatgagctt cgtctttaaa aatagatttt ggcagctgca 2837341 acagtgcgtt gatatgaacc ttatctttga aaaactgttt cagcttgccg ctttgggagc 2837401 tctcaaacaa atgattcgga atcataaaaa ataagtagcc gcccggtttg gtatgcttga 2837461 cgctctgttc aataaacaga tgatgagcga aggaatggcc ttcgtcagct ttgagctcaa 2837521 acgcttctgc tccttcgtca ttcggataat agccgactgg cagatcacaa atgaccgtgt 2837581 caactggatc gataaacaac ggctcaaggc tgtcctggtg gaaaagctca agctcttttt 2837641 tcagaaggtt cgcttgggca taggcgatct tcaagagcac atcatcaatt tcaatgccaa 2837701 agctgtttgc cgttttttca gacagctggt tcagcacggt aaacagaagg ttcccagttc 2837761 ccagggctgg atcaagaatg gtcagttcct ttttgtccgc cataaattta ttcaccaaat 2837821 agctgatgaa aagcccgatc gtatccggcg tcatttgtct gtttggatgc gagatatctt 2837881 tcattccttt aaggacggca agctgaaaag ccttgcgtac ccactcatgc tcatacgtgc 2837941 cgaattccgc tttttcaagc agagcctgaa gttgtttggt tttctgatca gcaggcagtt 2838001 tcagctgatc cgttttttca agaaaataca tttctcctgc ttcggccagc gcctctatat 2838061 atgaaatctg caattcattc tttatcataa tcgcggcttc gtttaacagc tcatacaccg 2838121 cacctacatg gtctttttgc atattgtgtt cctccttgcc atgaaaaaag ctccggcggc 2838181 agcctggagc ttttttccct gcttacttta ctaatgcctt agcagcctca attggctttt 2838241 catagttcgg gtggtttgtt gcttcgctta catattcagc gtaaacgact tttccgttct 2838301 catcaaggac aaatacggaa cgcgcaagca gacgaagttc tttaatatac acaccgaacg 2838361 cttcgccaaa tgacatatct ctgtggtcag acagtgtttc cactttgtca attccgttag 2838421 cgccgcacca gcgcgcttgc gcgaatggaa ggtctgcact gattgtgtag acgttgacat 2838481 ctccaagctt tgcagcttct tcgttaaaac ggcgtgtttg tgcatcacaa acacctgtat 2838541 caattgaagg gataacagaa ataatcgtta cctttccttt catgtcagct aacgattttt 2838601 cttcaaggct gttagtcagc actgtgaaat caggagcttg atctcctacc ttcacttctt 2838661 gtccgacaag tgtaaccgga ccgcctttga atgtaatttc agccattata attcctccct 2838721 tttgtatgta tgtctctatc atagtaaagt ttcctgcaaa ctgcaaagtt tatgccaaaa 2838781 aaaagttaac tgcggccagc gcagttaacc tttttttaat aattcatatt gttcatttgg 2838841 ttttgatttt ggccttggct ttggtttttg ttatttttct tgaacatttg ctggatgcgc 2838901 tcgagtgttt gaggggctgc gtctaaaatt ttctctatta aatgggtatt ttcatctaaa 2838961 tgaagcattc tgatgcctgt cgatccgaca attaaaaacg cgatcggcgt aatggacaca 2839021 ccgcccccgc ttccgcctcc gaaaggaagt ttctgttctc ttgtctcatc gtcttccgat 2839081 ttcttttcgg ccggctttcc gccaaactcg cttccgcctg cggcgaatcc gaatccaact 2839141 ttagaaacag ttaaaatcac acttccatca ggcgtttcca ctggatctcc gatgatggtg 2839201 ttaacatcaa tcatttcctt caagttttcc attgcggttt tcattaaacc ttggatggga 2839261 tggtctgcca tatacgcttc ctccttaaac tgatgaatca ttctttgaag tcattctagc 2839321 cgacggattc ttctttaata cggatagctc ccgtccgtat ttgacgaatt tgaaagctgc 2839381 aagcatagca tgtccaaagc gaaaaaagaa tatacactga aaatgggtct tggaaacagg 2839441 gacttgaaac gacgggatca cctcatagac aggtttattc acaaagtcca ggtggtcgta 2839501 gagcattgct gcgataccgc ccttcacgcc ccatacagca ccggttaaca cacctgtcac 2839561 tgccgcgtcc tgaattccga ttactgtaac ccattctagt tttgtgatat gtaaatgcgc 2839621 gagaaaagac gcgctgattt tccgcagtct ggtgacctga tgcaaaagca tttcgatttt 2839681 attaatgctt tgctgcacat cgttttgtgt aatttttttc tttccgctgc tttttttcat 2839741 tttggattca gttttttgtt tgatatccac tgttccgtct tctttgttca ccttaatcgc 2839801 cgggattgtt tttttgatcc ttataaggcc aaacagcgcc gtaatcttca aggtcaattt 2839861 gtcattatca tcggcatgaa gatactccag cgcgacatgg attttcattc tgagaagcag 2839921 tacgatccct atgagaataa gaatggctgt cagtacatac accatattct tcacttcctc 2839981 taggagcatt atcgccaatt cctaaaaaaa taaacccgga cggaagtccg ggttatcggt 2840041 tatttgcggt ataatttttc atgcaccacg gtggtatccg cgatgtaatc atgaatccct 2840101 tgttttgtag gtgaaaaggc aacaacgata tataaaatcc aaatcttatc aatataccgt 2840161 ccaaccactt cacgaaaaat cactgtactc catgtcagct tgctatcttg cttcacagaa 2840221 accactttga ggccgaacac cattttacca agcgtctgcc tgaagtattt tgtcatgagt 2840281 gcgaaatagg caagatacac aataagcgtt gtcacactgt aggccgagaa ggtaaacatg 2840341 ccggatgttt tcggcagatc caatacggta aagaggggag aaacgagcaa atggtttaat 2840401 ccccatatca cgagccaatc aagcaggaaa gcccagaaac gaacccaaaa gccagcatag 2840461 gcatgtgtca gcagctccgc ttcttgcggg cctttgatgt cattgcgctc taactcttca 2840521 tatgtcgcgt ccattattgt tccctcctac ttcgcataga gatacatcat tctcggcgaa 2840581 ccggattgcg atagaatttc tctcatattc aaaaaatcaa tttcactttt aaacattttg 2840641 ttcgcgccca tggaaaacag tgagcctaat ccgaagcttt cctcataaga aatgacagag 2840701 gcgtttttca aatccttgtg atcctttttc atggccgtaa tggtatcgtc ataaaaacca 2840761 agctcatcaa cgaggttcag ttttttcgcc tgccgtccgt catacacgcg gccgtccgca 2840821 attttcttta cctctgcttt cggcatgccg cgcccttttg aaatgacatc aacaaagcct 2840881 tcatacgaat tatcaaccat cgattgcatg atgttttttt cttctttcgt catctcacgg 2840941 gaaggagaca taatgtcctt atgggccccg ctcttaatcg tttcaaaaga aatgccaagc 2841001 ttgtcggcaa gctttgaata attgacgctt tccataatga cgccgagtga cccggtcagg 2841061 gtttccggtg tcgcaaaaat cttatcagcc gctgttgaga tgtaatagcc tcctgatgct 2841121 gccatcgaac ccattgacac gtaaatcggt tttttcgttt ctttcttgat ttcttccagt 2841181 ttcttatgta tttcagcact ttcatacact ccgccacccg gagaattcac cttcagaacg 2841241 atacctttga ccgtcttgtc atcttttgcg cgctcaaggt tttttaagaa cgttctgtgg 2841301 ttatatccgt ctgcaccaag cagactgctt gagtccccat tatcctgaat ggtgccgctg 2841361 acctctaata cggcaatttt acttgaggga ctgccgtttt ccagcgtctt ctcctgcgat 2841421 tcatccgtca gtgatgtgag atccgtttga gcgcctttga cgctttcaaa gaaactcata 2841481 gagatgctga cgataataga cacgccgaaa atccccagag caatcactaa tgcaatccat 2841541 ctttttgcat tcattttttc tcctcctttt tcctaaactc tctcattata cgattcaata 2841601 tgaaaaatgt ttcacttcat gagaaagctc cggcttaacg ggctgccggc aaacgtggta 2841661 cacttatggc caaaggtatt ttatcacaaa tactggatgg cagaaaaact taaatatgac 2841721 agcaaagggg aaatgggata tgaccgatca acgccgtaat gtttattttt ttcacaaaca 2841781 ggatcaggaa acgaacgaac aagcccgctc gttaacacaa ttagcggaag agcatggatt 2841841 taccgttgtg aaccagcact cagacgccaa tattatcgct agcattggcg gggacggcac 2841901 atttttgcag gcagtcagaa agacgaattt tcgtgacgac tgcttgtacg tcggcattac 2841961 caaaaagggg aaagctcatt tatattgcga ctttcatagt gatgagcgag aaaaaatggt 2842021 cgatgcaatg acgtttgaac aaattgaagt gagaaaatac ccgctgattg aagtgacagt 2842081 ggatcaagcc agtccttttc actgcttaaa cgaggtatcc atccgctcaa gcatcatcaa 2842141 aacctttgtg atggacgtgc tgattgacga tctgcacttt gaaacgttta gaggtgacgg 2842201 aatgattatc tcaacgccta cagggagcac cgcctataac aagtctgttg caggagctgt 2842261 tgttgatcca ttgcttccat gcatgcaggt atcagagctt gcatccctta acaataatac 2842321 ctaccggaca ctcggctcgc catttgtcct cagctctgac cgaaagctga cccttcgtgt 2842381 ggtgcaggac ggcaacgaac acccaatcat cggcttggac aatgaagcac tcagcacgag 2842441 aaatgtgaaa acgatcgaaa tcaaactgtc taataagaaa atcaaaacag tcaaactaaa 2842501 ggacaattca ttttgggaaa aagtgaagcg tactttttta tagaaaataa aaggacaggc 2842561 tgctgcctgt ccttttatga tttctcatat acaatctggc cgttaatcac ggttttttta 2842621 atctctaaaa gatgaagctg tgcggggtca atggcaaacg gatcaccact gagaactgta 2842681 aaatccgcgt catagccttc cgcaattttt ccgcgtgact tctctttata aatgataccg 2842741 gcgctacctt ctgtataaag ctttatcgct tcatatacag gtaaacattc actttcatta 2842801 tagcttggcc cgttttgctc atgactgctt ttccggagga ccgcggactg gatccctaga 2842861 agcgggtcaa caggctcaat cggggcgtct gaaccgcccg cgcataaaat gcctttagat 2842921 atgagggttt tccaggcaaa tgcagtcttc atccggtctt ttccgagacg gtcaatgacc 2842981 cacggaaagt cgcttgcaac gaagtgcggc tgaaggtcaa gtgcgatcgg catgcgtgct 2843041 gctctctcga ttaattcgtt atcaagcact tgagcatgaa taagccgatc atgccggccg 2843101 tttttgggcg gatgcttttc tattgcgttc agcacttttt caaaagcaag atcgccgatt 2843161 gcatgaacag caacctccat ccctttttct ctcgctttgc gaatgagccg gccaagggtt 2843221 tcgtcatcgt gaacctgaac accatttgtt gatggatcat cctgatatgg ttctttcaat 2843281 aaagccgttc tcccgccaag cgccccgtcc gcaaagattt tcatagcacc gaactccaca 2843341 tacgggccgg acagcttctc cagctgctcc catcgatcga cagcttcatg atgaacgagc 2843401 aaatggcagc gaaacggata ctttccgcca gcggcagctt tctcataagc tttcatcggc 2843461 accgaaacat caccataata ggacaagtct tccgaatgac cgcccgtcag gccttttgtc 2843521 cagcaatcct ttattgcagc cgttaatgcc tcatcaacat agtgctggga gactggcggg 2843581 acagccttca gaatcaaatc ctgcgcctta tcaaacagga gtccggtcgg ctcgccattt 2843641 gcatctttta cgatgactcc gccgtcagga tcaggagtat ttcttgaaat tcccgctgct 2843701 tgaagagccg cagaattgac agctattgca tgccggcata tacgcttgag caagacgggc 2843761 ctgtcaggaa acaggcgatc aagatcatgc ttagtcaagt agtcaggtgt ctcaaactga 2843821 ttttcattcc agccttctcc aatgagccaa tcgtttttag gaagctgccg ctctctttcc 2843881 ttcgcagcct gtaaaattga atctttcgac gtcagtgcgg acagatcgag ctgaagctgt 2843941 ttctcaccgt ggccgatcaa atgtagatgg ctgtcaacaa aaccggggaa catcactgct 2844001 ccgttcaggc tgatttcttc tgtttccggc gacccgtact tttccttcaa acgttcatag 2844061 ctgccggtgc cttttataac accatcctca acataaactg cctcagtccg atcgccttct 2844121 tcgagcatcg tataaatgaa accgccgtgc catatcgcct tcattcacgt tcactctctt 2844181 tctttacgcc tttttattgg ctttgagctg ttcttcacgt tttcttaatt ccactcgtct 2844241 gatttttgca gaagccgttt tcggcaggct ttccacaaat tcaatttctc taggatattt 2844301 gtatggagcg gtaatcgtct tcacatggtt ttgcagcatt ttgacaagct catcactgcg 2844361 tttttcatga ttttgcagga caacatatgc ctttacgatg gagcctctga tttcatcagg 2844421 gcttgcgaca acagcacatt cttttacttc tgggtgctta acaagcgcgt cttccacctc 2844481 gaaaggcccg atcgtatagc cggagctgat aataatatcg tcatttcggc tttcaaacca 2844541 gaagtaacct tcctcatctt ttcttgctct gtctcccgtt aggaaataat cgccgcgaat 2844601 ttgtgttttc attctttccg gatctttaaa atactcttta aagagcgcag gcgtactgag 2844661 gtgaacagcg atatcgccaa cctcaccagg tttgcagatt tcaccgtctt catttatgat 2844721 ctccacctga tttcccggtg tcggttttcc catgcttccc ggtttaatag gcgtatcttt 2844781 caaaacacca accaaaagcg tgctttctgt ttggccatat ccgtcccgta ccttaatgcc 2844841 aaagtgcttt tggaaaacat caatgacttc acggttgagc ggctcacctg cggaaacagc 2844901 gctgtgcagg gcagaaagat caaagcgttt caagccttca accttcgcca ttaagcggta 2844961 ttctgtcgga gtgcagcaga aaacattgat tttgtagcga tttaaaagct ctagatattt 2845021 ttctgctttg aatctgccgt ggtacacaaa accggttgct ccgctgccaa gcaccgctaa 2845081 aaacggactc catacccact tttgccagcc aggggcagca gttgcccaga cgatatcctt 2845141 ttcagaaatg tcaagccaag cgccggcaga agtttttaaa tgagcaaatg cccatccatg 2845201 tgtatgtaca acacctttcg gctgacctgt tgtcccggat gtataagata agaaagccat 2845261 atcatctctt gttgtgtcag ctgttttaaa ttggcttccg tccgcttcaa ttgataagag 2845321 gtttttccag ccggcatcat tttcaccaat agacagtgta atcagtttgt cagccgtact 2845381 gacatcccgg aaagcgccaa taaattcgga gtagacgata gcgcctttta cctctgcatg 2845441 ttcaatccgg tattcaagat ctttcgcgcg aagcatttcg gagcacggaa tgacaaccat 2845501 tcctgatttc aggatagcca aataaacagc ataggcttca agcacccgcg gaaccattac 2845561 aatcagcttg tctccctttt taaatccaag atcagctaag gccgctccga ttttatttgt 2845621 ttcttccatc agcttttcat acgaccaaga ttcttgcttg cccgactcgt cctcccaaag 2845681 aagagcggtt ttttgtccag cagcactgaa cttttccatt tcattcacta aattatattg 2845741 cacaggggca attaaatctt cacgttttaa cacgaacaac tcctcacttt ctccacccat 2845801 tatacataaa tacaggctct ttccgtaagg atatgcctaa aagcaacctc tgtaaacata 2845861 gattttatag gccgctggtc cttttttata tgtaaaaaat gaaaaagagt ggggataccc 2845921 ccactcctaa gccattatgt gaaattgtaa attagaattg tcctccgccc atgttttgtt 2845981 gagcaaaaga tacaagacgt tttgtgatct ctcctccaac agaaccgtta gcgcgagaag 2846041 ttgtgtctgc tccaaggttt acaccgaatt cagaagcgat ttctaatttc atttggtcga 2846101 tcgcttgagc agctcctggt actaaaaggt tgttgctgtt acctgagtta ttgttagcca 2846161 tgtgtctcac ctccttgtga gtatagaatg tgtcaaaaca catggcttca ttcagaaaaa 2846221 ctttggtaat tgtatacagg agctgaaaat tgatttaaaa gagttcagcg aatttatcgt 2846281 tagcttcttg ttcgctataa agggtcattg tctcaatgtt atctaccgct tcttgaatat 2846341 acggctcgaa atcaacaaag ctttcaaagt gttcaatttt ctctttttta gggcgtgttt 2846401 tcgggcttgg cggtgtaaag atcgtgcagc agtcttcaaa cggctgaata cttgtctcat 2846461 atgtgccaat ttcccgtgat ttttcgatga tttctgtttt gtccatggcg attagcggac 2846521 gcaaaatcgg tgttgacgtc accgcattaa ttgcatacat gctttcaagc gtttggctcg 2846581 ctacctgacc gaggctttct cccgtaataa tggcaagccc gtttctcttt tctctgattc 2846641 tgtcggctat ctgaagcatg aggcggcggg ttgccgtcat tgtgtaattt tcaggaattt 2846701 gtttttggat gagctcttgc gtttttgtaa atggaacaat atgaagtgtc atgcttcccc 2846761 caaaacggga cagacatttc gccagatcca ttaccttttg ctttgcgcgc tcgcttgtgt 2846821 atggcgggct gaagaaatga acagcttcta ccgacaatcc ccgtttcatc gcataaaaac 2846881 cggccacagg gctgtcaaaa ccgccagaaa gcatcagcat cgcttttcct gctgaaccaa 2846941 ctggcagccc gcctgcacct ttttcatcac gaattgtcaa aaatgttgct tcttccctga 2847001 tttcgattct gagcgggatg tctgggttgc gaacatcgac cgtcaatcct tctgtatttc 2847061 gcaaaatatg gccgccgatt tcagcgttca tctggtttgt atctaattca aattgcttat 2847121 acgctctctt tgtcgcgact ttaaacgtat cacctggttt atactgatct ttgatagcct 2847181 ttagtgcggt tgccttaata tcatcaaggc ggctgtcaca cttaattgcc aggctgaagc 2847241 tttgaatccc aaacacttgc tttaaatgag gaaaaagagc ctcaggatcc tctccattta 2847301 atgtaatcgt catacgatcc ctgttggaaa agtattttaa attcggatag tctttcaaaa 2847361 cgagtctgat gttttgtttt aagcgctcaa taaagctttt tctgtttttg cctttggtcg 2847421 aaatttcccc aaaacgaatt aatatatgat cgtaattcat gttctacctc atcatttccc 2847481 ttaatttttt gatgccagga cgaagcgcgt tcataaacgg ttctgccaca tcgcttgtct 2847541 ggctgtaatt taaactgatt ctgatgctgc ttccggcaat ctgctctcct ttgcccatct 2847601 ctaagagaac cttgctgggc ttatgttctt ttgccgagca agccgatgtt gtggagacga 2847661 atatatcctg ttcctcaagc atgtgtaaaa gcacttccgc tttaatcccc ggtacagaga 2847721 aattaataat gtgcggcgcg ctattcattt gaggcgtgtt gataacgacg ccctcaattt 2847781 cactcagcct attcataaac aattccttta cggcagtcat cgtgtcaagc cgtgtgtcaa 2847841 aatcagcaga ggccagatta atggccttgg caagcgaaac cgcaccagca gtatgttctg 2847901 ttccggcccg tatgcctttt tgctgagagc ctcccgttat gagcggaata aggcgtgttc 2847961 cttcttttac aataagtgcg cctgtcccct ttaggccgtg aaatttatgc cccgaaattg 2848021 aacatagatc aatgccggcc ttttcaattg ccaagggcac tttatagatg ccctgcacat 2848081 aatcgacgtg aaacaaaatg ttcgaatgct ctttcagcac ttctcctgcc gcttcaatcg 2848141 gctgcacgga accgacttca ttgttcacat gcatcatgct gacaagcacg gtatcgggac 2848201 ggatggctgc ttttagatct tcaatagaaa caaatccgtc ttcattcaca gaaagataag 2848261 tgatatcaaa cccgaacaac tctttcagct gttctaacga ttccgtaacg gatggatgtt 2848321 caatagaagt ggcaatgata tgtttgcctg tttttatctt tgacaaagcc gctcctttta 2848381 aagccgcatt attggcttct gtggcgcctg acgtaaatac aatatcatat ttttttaggc 2848441 ctaaggacct tttgatttga tttttggctg cttgaagcag ctgttccgtt tcggctccat 2848501 atcggtgcaa agatgaagga ttgccaaagt atcggctgct cgtctgttca tatacgttca 2848561 agacttcatc gtaaggcttc gtcgttgaac tattatctaa atatatcatc ttttttactc 2848621 ctttatgaaa gcggtacaag gtatgatatt tatgttacca taacaaaatt taatagaaaa 2848681 ttacgaaaaa ctagtattga cttctaattt ttttaccata taataagatt tgttcgtttc 2848741 gtcatattat ctgacaatta attgacagaa tattttaaca taattattag gaggattttt 2848801 ttcatgaaac actcactgcc tgtcaaagat accattatta ttggtttcat gctatttgcg 2848861 ttattctttg gagcaggaaa tatgatttat ccgccggaac ttggacaagc agccggacac 2848921 aacgtctgga aggccatcgg cggattttta ctgacagggg taggcctgcc gcttctcggc 2848981 attatcgcca tcgcattaac cggtaaggac gctaaaggcc ttgctgacaa agcgcaccct 2849041 gttttcggca caatctttac tgtcgtgctt tatttatcaa tcggaccatt attcgccatc 2849101 ccgagaacag gaactgtttc atatgaaatt ggcgctgttc cgtttttgac tggtgtacca 2849161 gaaagacttt ctttattaat atttacactt atctttttcg gcgttacgta ctatttagcg 2849221 ttaaacccat ctaaggttgt ggatcgagtc ggaaaaattc tgactcccat caaattcaca 2849281 attattttaa tcattgttct caaagccatc ttcacgccga tgggcggatt gggcgccgtg 2849341 acagaagcat ataaaggaac accggttttt aaaggatttt tagaaggcta taaaacaatg 2849401 gacgcacttg cttcaattgt atttggcgtt gtcgttgtaa atgctgtaaa aagcaaaggc 2849461 gttacacagt ctaaagctct tgctgcagcc tgcattaaag caggtgtgat tgccgcttta 2849521 ggcctgactt tcatttatgt atcccttgct tatttaggtg caacaagcac aaatgccatt 2849581 ggtcctgttg gtgaaggagc taaaatttta tctgcgtctt cccattattt attcggttca 2849641 ttgggcaaca tcgtactcgg agcagcgatt acagtcgcat gtttaacaac aagcatcggc 2849701 cttgtcacat cttgcggcca atatttttca aaacttattc cggcattatc atataaaatt 2849761 gtcgttacga ttgtcacgtt attcagcttg atcattgcga atttcggact cgcgcaaatt 2849821 atcgcgtttt ctgttcctat tttatcagct atctatccgc ttgccattgt cattatcgtt 2849881 ctttccttca tcgataagat ctttaaagaa agacgcgaag tgtacatcgc atgcttgatc 2849941 ggtacaggac ttttcagtat tttagacggt atcaaagcag ccggtttttc acttggatct 2850001 ttagatgtgt ttctaaatgc gaatcttcct ctttacagcc tcggcatcgg ctgggtgctt 2850061 ccaggaatcg tcggagcggt tatcggctat gtgctgacct tattcatcgg accatccaaa 2850121 cagcttaatg aaataagtta atgtcacaga acgcctgcgt tattgcgcag gcgttttgta 2850181 ataaaaaaag agcctgctca ttacactgcg ggctcttttt catggtcgtg attatctaag 2850241 cggatatgtc agctttgatt ttttcaactg cacctggcgc agccttttct acagcggcag 2850301 cggcaatttc ataagagtcg tcataatcaa aagcataaaa acgtctttcc gcttctttca 2850361 gctgttcaga taaaatatga ttctggcttc tgaaccggtt tccgaactga atgatttttt 2850421 caatgaggat gacctgctcg acaagttcct ctgattcccg gcttgccctg ttgacgatat 2850481 cttctgcttg tttcaaatgg gctccggctt cttccatatt taatggaagt tcgtttagtt 2850541 gattgaccgt ttcttgaata tgatgatgcg cgttctccag catctcttga atatggctcg 2850601 gaatgcctgg aatgttgcta gtcttcagca gtcttgctgt ctcagaaatt gtttttttca 2850661 aattgctgag cgtctccctc gcctgaagct cttcttttct cagcgcttgc agattttcac 2850721 gatactcggc atgctctttt ttcacttctt caatttgctt ctctattgaa gcaacttctt 2850781 ctactaaaag tgagtaggcg acatgctctg catcaagctt atctttaacg gatgatagca 2850841 gctttccaat ttcatcaagg cgcttttcaa aagcctgctg tttgccgagc tcaccggctg 2850901 tcagcctgta gctttccttc accagctcag tttccgcttt cgtatgctct ttctcttctt 2850961 taagcttgtc gtaagcaata atcaattcag gcattttgct tagtacggat tgaccggctt 2851021 caacttcgcc ctccagctgc tgataaacag attgaatatt ttcgtcaatg agctgcagga 2851081 ttgcggacgc ttcatcaata tccagttcag tcatcaggac atgttccgct cgtttcagct 2851141 ggtttgacag attttctaat tccttatcaa gctggatatg ctcaagcttg tacccttttt 2851201 ctttcatttc gccatagcca tccttgagct ttgcaatctg tccgggcacc gtctgtttac 2851261 agtcagctaa cagcttcggc acatcatcta tgtatgactg aagccgttca agattgcggt 2851321 cctgctcaag cagtactttt cgtgcagtaa tatagtttcc gccttctgtt tcttcttcaa 2851381 attgtttgat gccgctccaa atttcgtcca gatccttttc aaggctgtca taaagctccc 2851441 cgtaaaggtg gctgtaagcc agcaggtttt ttcgagattt cgaatagcgc tccctcacct 2851501 gttcaatctc ttcacggctc ttttcctcac ttgtgacaag atcgctgatt tcccgaagaa 2851561 tcttttcaat gcttgattca gccgctgtca gcaggtcgtc gatatgaacg agcacttgat 2851621 tggccttttt aaaccggtat ttgtctgcat tttcctcggc atcataaagg agctcttcaa 2851681 ctttcggcat gtgggctgtg acaatctcat cccattcttc acgccacttc tcaaagaact 2851741 cttctgtctg acccgtcatt tttaaatgtt ttattttaga catttcttcc acgatcgacc 2851801 gattcagaat ttcaatcttc cacgattcca gccggtcgat ttcggcgtag atttttttcc 2851861 tgaaaaagta gcctgccgca aacagcgcaa gcagtacaat taataatcca atgacaaact 2851921 ccataatgag cccccttgct gtttacctta atctgtcagg gtgttttatt tattcagaaa 2851981 gatttcagga tatgtattga gaaaaactgt cgttttcatt gttattatga taccatgtaa 2852041 caaacatttt ttgaccagaa atcaaaaact ttttgtgcaa aatcggcagg atttgactat 2852101 tttttcatgg ggtgacatca atgcaaaagc gagacggaca tattcacaca ccattttgcc 2852161 ctcacggctc caatgacaca ctcagacaat atgcagaaga agccttaaaa aaagggttcg 2852221 aatcgattac ttttaccgaa cacgccccat tgccgccatc ttttaccgat cccacgccgc 2852281 tgaaagacag cgcgatggcg caagcttctt tggaacgcta tattcatgaa atttccggat 2852341 taaaaaaaga atatcgcgga cagcttagca tacggacagg gcttgaagtc gattatatcg 2852401 ctgaatttga agacgaaatt acattattcc tagacacata cgggccatat ttagatgaca 2852461 gcatcttatc cgttcatttt ttgcgcacag actcttccta tctatgcctt gattatgacg 2852521 agcatacctt caaagagctg atttcagcct gcggaagcat tgaagcggta tatgaacaat 2852581 attaccggag tatctattct tccattgtag catctctcgg cgtttataag ccaaaaagag 2852641 tcggtcacat cacactcgtc caaaaattca tcaagctgtt tccatacagc atgtcagagc 2852701 atattcgcgg cctcgtttct ctgtgcctga atgccattga agaaaacgga atggagctcg 2852761 acttcaatac ttccggctta agaaaaactt acgctggcgg tatttatatc gaggattgga 2852821 tgctgaatga agcgaagcaa aagaagatcc cgcttgtgtt tgggtctgat gcccatcaag 2852881 cgggagatgt cggatatgcg tatgaggcgt ttttggaacg gtgctagttg gtgagcgcca 2852941 cgtctcctgt ccggaagacg cttctgatcc aaatcttgat ttcttcaaaa tacattttat 2853001 aaaaatacgg ctcgtgcggc tgcatgtaga gtacttctga aatatattga ggctggagat 2853061 agggcatcat caagagagat tttaattgga gaataaaatg aggcagcggc agcgttaaat 2853121 attcacgctg tttttctcct tcctcaatga tcagctggaa gatatacttt tccttcatta 2853181 gatatgtcga cataatttcc ctgattaatg tggagtcaat tgtgacttcc cggtagacaa 2853241 aacgagttaa ttgacgatga ttatgctgat aggataaaat atcgaaaacc aattgaagaa 2853301 gctgttcctg cgtgctttga gtagagatat tgcttgccgc tgtttcaagc gttttgctgt 2853361 agccttcgta aaactctgaa actaagtgtt ccatcaagcc tcctttgcct ttaaaatagt 2853421 aggagatgtg cgcaacattt acatcagctg actttgcgat ttcacggaca gacgtgccag 2853481 aaaatccttt ttggttaaaa agcatgacag cagattcaat aattttgtct ttggtgctta 2853541 ctttcatacg gctcactcct tcctcttgat actattcaag cagaaagccg ctgttcctgt 2853601 aagaacttat cgacaaatgc cggcagaaaa gccggaactt tgttttatat tatagaaaaa 2853661 gtgagggttt tccatgttcc atgtcgaaaa acaatctgga gataaagaaa aagactatca 2853721 gcttctgcta aaacagctcg aagccatgac cgaagacgaa acagaccaaa tagctaacta 2853781 tgcaaatgcc tcagcactgc tgtatcattc gctgcctgaa gtcaactggg cgggtttcta 2853841 ttttgccaaa gaagaggatg gacagcttgt gttaggtccg ttccaaggcc tgccggcatg 2853901 tgttcggatt cctttcggca gaggggtttg cggcacagcg tacgcaaacg gaaaagtgga 2853961 acgtattgag gatgtaaacg cgtttccggg acatatcgcc tgcgatgcag cgtctcaatc 2854021 agaaattgtg cttccgattc gtgtagacgg aaaaattgtc ggcgtcttgg acatcgacag 2854081 cccagtgaaa aaccgtttcg acgaaattga tgaaaaatac ttaactcaat ttgccgaaac 2854141 gctagaaaaa gcgttagcgc agtaatataa aagcccaaaa ctgatatcgt tttgggcttt 2854201 ttttatttta ttgagtcatg aatcatcaag cggtttttcc cgctccgttt cgcgctgtag 2854261 agcgcttcat ctgcctcatg cacaagctct ttcagcgact tttttgtttc tgtcgtccag 2854321 caggagatac cgcaggaaat ggttacctcg ggtttcgtat tttttctgac cgcgtaaacc 2854381 agtcgctcgg taatccgttt ccccactgca accggcacat ttggcaaata aatcgccagc 2854441 tcctctcctc cccagcgggc accgacatca tgctttcgga tgttgctttt aatcactgaa 2854501 gcgacttgaa ttaaaatctc gtccccagtc tgatggccgt acgtatcatt tacattttta 2854561 aaattatcaa tatcaacaag aataaaaaca cccttttgat ggattttcat gctgtattga 2854621 attttttcat ctaaatacgc tcgtgaatac agttcagtca gctgatctgt tttcacgaga 2854681 tgctcaaggc ggtcgcgaag cattgaattg gttacagcca gtgtcgcgtg atgaatcagc 2854741 gcctgaaaca gcttgtacat ttcaaatgta aaagcgtaca gctcctgttt caataaaacc 2854801 gcaaagccta aaagccggtc gttttgaatc atcggagcag ccatcagcga gccgtacccc 2854861 gccttcccaa aaacagactg gccattcccg atgaaaaccc ctttttcacc ttcatacagc 2854921 ttttctttca gctcattata aaaatctgac ggcttcgctt ctttaaaaaa tgctgtgctg 2854981 cctgggagca atgttaggtt ttcaaaatgg tctatatgaa aaaatcccac ttcttctgcc 2855041 tgaaacgatt ctgccattct cacagccaga tcattcattg tatcagtcaa tgtcagccgc 2855101 tgattcaggc gtcgtgatgt ttcattaatc aattccaaat ttgcgatgct tgctttggat 2855161 tgttcgtaga gctgggcatt ttcaaacgct tttcccgcgg cgtttgctaa cagcgacatt 2855221 tcatcaaggc aggcatcagt aagaaagctg tcacccgttc cttcagcctt caacaccccg 2855281 tatgtgccct gctgtccttt gatcggaata taggcgacag attcattttt ccgcaaaatg 2855341 tctccggaca aatacacttt gagcgcaaag gaatcggatt tttccccttc catatacagc 2855401 tcttttgcag gaatccctaa acattggtct tgatcgtgcg atataaataa agaaaactca 2855461 aaaagagaaa atgtgcttgt caagctttct aaaagctgct tcagcacatc tgtctgatca 2855521 agcagtgaat ggaacagctc tgtcattttg tatatctttt tttggtagat cgttttgtta 2855581 tagagtcttt cctgtttcat cgactggttt aaaaatgaag caaccacgtc cggaagccct 2855641 tcaggaatct cttcatcctg cctgcacgca agatggaaac gcctgccgga gccgtcctca 2855701 atcagataac atgaagcgtt tatttttgaa gcggaaaaac gcgcttcacc atctgccagt 2855761 tttgtcacaa agtctgatgg tgacggtgta agcgaaacac aaagggttga aaaataggtt 2855821 tgaatagccg aagtcagcca tatgaaagag tcggtgaatg tgactttttc agatttggtt 2855881 aataaaaaat cgagcatatg ataatgaaag gcggataatt gatctttagt ttgttctacc 2855941 atgtttttat cacctaaaag tttaccacta atttttgttt attatatcat aaacggtgaa 2856001 gcaataatgg aggaatggtt gacttcaaaa caaataaatt atataatgac ctttgtgtga 2856061 aatattgcag cctttttgtt cagcttctat gttttcattt tgttccttat caataaggtg 2856121 tatcgtgtaa ctctctgctg ctggagcgag gatacatgaa aacaaaatgt gcatggtcga 2856181 atagagcaga cggtttttat tttccacaaa aataaaacca aaggaggagt cacattatgg 2856241 ctcgctatac aggtccatct tggaaactgt cccgccgtct aggaatctct cttagcggta 2856301 caggaaaaga attagaaaaa cgcccttacg ctccaggtcc acacggccca ggacaacgta 2856361 aaaaattatc agaatacggt ttgcaattgc aagaaaagca aaagcttcgt cacatgtacg 2856421 gtgtaaacga acgtcaattc cgcactttgt ttgacaaagc tggcaaacta gctggtaaac 2856481 acggtgaaaa cttcatgatt cttttagatt ctcgtcttga taacgttgtg tacaagctag 2856541 gtttagcacg tactcgccgt caagctcgcc aattggttaa ccacggtcac attcttgtag 2856601 acggaagccg cgttgacatc ccgtcttacc tagtgaaacc tggtcaaaca atcggtgttc 2856661 gcgaaaaatc aagaaacctt tctatcatca aagaatctgt tgaagtgaac aacttcgttc 2856721 ctgaatacct tactttcgac gctgaaaagc ttgaaggtac tttcactcgt cttcctgagc 2856781 gttctgaact tgctccggaa attaacgaag cgcttatcgt tgagttctac tctcgttaat 2856841 cgttttaaaa acccctgccg ctatgcggtc ggggtttttt tatcggcttt cgcctcttgc 2856901 tggccaacac tatcttgcgc ctgctgctcc caatgatccc gctgcagccg ttcttttgca 2856961 atcgtacaca tgagattcac gctttagcgc tcctttcatt taaaaggtgg tgattggtcg 2857021 tgtttgccct atctaatata ctcttttcct ttcattccta tgcggtaaac aaaaagatcc 2857081 tttgccttca gtggcaaagg atctttttct tatttatacg tcacaaggaa gtattttttc 2857141 ttcccgcggc gcagaacagt aaattggttt tcgatgcggt cttcacctga tagggtataa 2857201 tttatttccg tctggcgttc accgttaatg taaacagctc cgttttggat gtcttcacgc 2857261 gcttggcgtt tagaaggaga taatttagat tgcaccaaca catctacaag tgaaagctct 2857321 tgggtgctgt caacttccat agaaggaaca tctttaaagc ctacttttac gtcttgagca 2857381 gaaagctctt taatattgcc gctgaacagc gcttgggaga tgttgatggc ttgctccagc 2857441 gcctcgcgtc cgtgaacaag tgatgtcact tcttctgcca ggcgtttttg cgcttcacgt 2857501 ttttctggcg ccgtttctgt tttttcagcg tatgcttcaa tttcctcttt tgaaaggaac 2857561 gtgaagtatt tcaagtattt gacaacgtca cggtcgtctg tgttgatcca gaattgatag 2857621 aattcatatg gcgatgtttt ttctttatca agccagatcg cgccgccttc cgtttttccg 2857681 aacttcgtgc cgtctgcttt tgtgacaagc ggaatcgtta ggccaaacgc ttttgctcct 2857741 tcttcttctg attttctgat cagttcaaga cccgctgtga tgttgcccca ctgatcgctt 2857801 ccgccgattt gcagtttaca gtttttgtct ctgtaaagat ttaagaaatc ataagattga 2857861 agaatcatgt agctgaattc cgtgtacgag atgccggatt caattcttga gctgaccgta 2857921 tcttttgcca gcatgtaatt gatgccgaaa tttttaccaa cgtcacgaag gaaatcgatc 2857981 acattcattt tgccgatcca gtcaaagttg ttcgcgatga cagctgggtt ttctgctgct 2858041 tcaaaatcta gaaatctgga cagctggttt ttgatttttt gggaccattc ggatacgatg 2858101 tcagcagtgt ttaatgtacg ctctgctttt tttccgcttg gatcaccgat gaggcccgtc 2858161 gcgccgccca caagcgcaat cggatgatgc cctgcaagct gaaaacggcg aagtgttaaa 2858221 ataggcagca ggtgtccgat atgcaagctg tctgctgtag ggtcaaagcc tgagtacaag 2858281 cggatttttt cttcattcag ctgtttattt aacccttctt catctgtcat ttgctgaatc 2858341 aatccgcgga aggataagtc ttcaagtaag ttagtcataa gataaagctc cttttttaat 2858401 taaaataaaa aacgcccctt cgtttacacg aagggacgat tgattatcgc ggtaccaccc 2858461 tactaataag agaatgcaaa cattcgtctt atcactttgc ctgataacgg atcaggtccg 2858521 ttctttcact actgaaagcc tggccggctt tgtttgcaaa agcggttcat gagtgtattc 2858581 gatatatccg tctgtgctga ttttcaccgg ccatcagctc tctggaacgt aaggatattc 2858641 tacttgtctc aatctttacc ttttcatatg aagctatatc atttttaaca taaataaaat 2858701 cctgtgtcaa cgccgccttt taatcctcca ttgttgacag atctccagcc ggcagattaa 2858761 gctcccatgc cttcagcacg cgcctcatga tctttccgct tctggttttc ggaagcttat 2858821 ctttaaattc gatctcacgc ggagccgcat gggctgcaag accctgcttt acaaataggc 2858881 ggatctcttc tttcagttta tcagacggct caaatccttc cctgagtgca ataaaggctt 2858941 taatgatttc tccacgcacc gggtcaggct ttccgataac gcctgcttct gcaatagccg 2859001 gatgttcgac aagcttgctt tccacttcaa atgggccgac gcgctcaccg gaggtcatga 2859061 tgacgtcatc aactctgcct tggaaccaaa agtatccctc ttcatccatg taagcagaat 2859121 ccccagacac ataccagccg cccggcatga aatacgattc atacttttca gggttattcc 2859181 aaatggtatg catcatggaa ggccagccct ttttgatggc gagattgccc attcggtacg 2859241 gcggtagctc gttgccttga ttgtcaacga tcgctgcctc cactcctgga atcggcttac 2859301 ccattgaacc cggtttaata tccatgcaag gatagttgca gatgagctga ctgcccgttt 2859361 cggtcatcca ccaggtatca tggattcgtt tgttaaaaac tttatgtccc catctgatga 2859421 cttccggatt tagcggctca ccgacactga gcacatgccg gagtgaagtt agatcatatt 2859481 tcgcagccat ttcatctccc gctcccatca gcatccgaaa agctgtcggc gcgctgtacc 2859541 agacattgac gccaagctgt tcaatcgttc cataccagct ttccgggctg aaacgtccgc 2859601 cgacgatgac atttgtcgct ccgttcagcc acggtgcaaa aatgccgtat accgtacctg 2859661 tcacccagcc tggatcagcc gtgcaccaat aaatgtcttc ttcctttaaa tcaaggaccc 2859721 actttcctgt ttgatattgc tgaatcatcg cttcatggac atgcaacacg ccctttggcg 2859781 taccagtgga acctgatgta tagtgaagca gaaagccgtc ttttttatcc atccattcga 2859841 tatccaatct tgtgctttcc tgtttcgctg cttcatcata attgatgata ttcgtgccgc 2859901 tctcagcctc tcccccgact acgaagacat gctgcaagtg aggcagtttg tctaccggta 2859961 ttctctccag cagctcaggc gttgtgacaa caacctttgc ctcactgttt tcaagccggt 2860021 ctttcaccgc tccctccata aatgcttcga acagcggccc ggcgatggcg ccaattttga 2860081 ttgcgccaag cataataaaa taaagctcgg gtgatctcgg cataaaaata aaaacgcggt 2860141 cccctttttc cacatttcca taccgtctca gcacattccc ggctctgttt gattcttcct 2860201 tcatttcttt aaatgtgtat ttttcatccc tttttgcgtc tttataataa agcgctactt 2860261 tgttttttcg aaacgattcg gcatggcggt caatcgcttc atacgccgca ttcagtttcc 2860321 ctgtctcatg ccaagagaaa tgtttctctg cctcggccca atcaaaatgc cggtacgttt 2860381 cttcatagtt ttttaagtta tgatccccct ctattgctgg taacgctttc aagttcatgc 2860441 ccaaacatcc ccctttgctg aagttgtcac aattattata gtatatattc atattcttct 2860501 caatttttaa aatataaacc atgttgaaaa cgctttataa tttggtattc ttaaagaagg 2860561 catgtatttt tgataagaat tgatgggacg gtgaattagt ggaacatcat aaaacatacc 2860621 attcagcaaa catcaaaaca gcaaccggct ctttactgat agaagggcct gtctctccag 2860681 aggatttggc aggttatgag tttcataaag atttaaccgc atttcgcccg cctcgcgagc 2860741 agcatgaagc gctagtcgac attgcaggcc ttcccgaagg gcgcattatt attgccagag 2860801 acggccgaac cattgtcggc tatgtcacgt atttatatcc tgacccgctc gaaagatggt 2860861 ctgaaggaaa tatggaggat ttgattgagc tcggagccat cgaagtagcg ccggactatc 2860921 ggggatgcgc tgtcggaaag acgctcctga ccgtcagcat gatggatgaa caaatggaaa 2860981 actacattgt gatgacgaca gaatattact ggcattggga tttaaaaggg atgaaaaaag 2861041 atgtgtggga atacagaaag atcatggaaa agatgatgaa tgcaggcgga ttggtctggt 2861101 ttgcaacgga tgagccggag atcagctccc accctgcaaa ctgtctgatg gcccgcattg 2861161 gaaaaaacgt cagccaagaa tcaattgagc aatttgacag gctccgtttt tatcatcgtt 2861221 atatgtatta actgacactg acaaagggga aaaaataatg attgttgagc aaatcatgaa 2861281 aagagatgtc attacattaa cgaagacgga tacgcttgaa acagcaatat gcaaactgaa 2861341 ggaattccat atcaggcatc tgcctgttgt agatgaagaa cgacacgtga tcggcatgat 2861401 tacagacagg gacatgaaac aggccagccc gagtattttt gaagaaaaca aacgaagcct 2861461 atttctcaca cgaagcgtag attcaattat gaaaaaggat gttgtctgcg cccacccgtt 2861521 agattttgtc gaagaaatat cagccgtgtt ctacgagcat ggcatcggct gcctaccagt 2861581 ggtacaccat caaaaattaa taggcatttt aacaaaaacc gatttgctgc ggacgtttgt 2861641 caaattgaca ggcgctgacc agccgggctc gcaaattgag ataaaagtaa acgacatcac 2861701 caaaagcctc gctgagatca gcagtctttg ccaagacctt caagtgaaaa tattaagcgt 2861761 gcttgtttat ccgcatgacg atcccggtgt aaaagtgctt gtcttccgtg taaaaacgat 2861821 gaatccgctg ccgtttttgc aggcattaca aagaaatgga caccacgtcg tatggccgtc 2861881 agagcaaagg gatctgctat gagagacagt gtatttatct attctccatc ctaccaaacc 2861941 tatatgtttc atcaggagca tccctttaat cagcagcggg ttctgttaac atatgatttg 2862001 cttaagacga tcaatgcctt tgatgatgga gacattgtca cccccagact cgcttcagaa 2862061 gaggagcttt cccttgtcca cacggacgat tacattcagg ccgtaaagct tgcgggcgcc 2862121 ggaaagctcc ccgctgaaga aggagaaagc tacgggctcg gcactgaaga cacacccgtc 2862181 tttgccggca tgcacgaagc ggcatcactc ttggtcggcg gcactttaac ggccgcagac 2862241 tgggtcatgt caggacaagc cctgcatgcg gcaaaccttg gcggagggct tcatcacggc 2862301 tttcgcggga gagcatcagg attctgcata tacaacgaca gcgctgtggc tattcaatat 2862361 atccagaaaa aatatagcgc cagagtgctt tatattgata cggacgccca ccacggggac 2862421 ggtgtgcaat ttacatttta cgataatcct gacgtatgca cgctgtccat tcatgaaaca 2862481 ggaaggtatt tattccctgg aaccggtcag atccaagaaa aaggaagcgg aaaaggatat 2862541 ggctattcct ttaatattcc gcttgacgct tttacagagg atgattcttt tcttgaggct 2862601 taccggacag cagcttcaga agtcgccgcg tatttcgagc ccgatgtcat tatcagccaa 2862661 aacggcgccg atgcccatta ctacgacccg ctgacgcatt tatcagcaac aatcaatata 2862721 tacgaagaaa tcccccgtct tgcacacact ttggctcatc aatattgcgg agggaaatgg 2862781 attgcagtcg gaggcggcgg atatgatatt tggcgtgtcg tgccccgcgc ctgggccaga 2862841 atatggcttg aaatgaaggg aattgacccg ggtcacgaga tcccgccgga atggattgtt 2862901 aaatggcaaa aacaatgccc cgtggccctt ccgtcgagct ggagcgatcc ggctgattta 2862961 tatcctccga ttccccgcaa gcctgaaatt acagaaaaaa atgcccaaac tgtcagcaaa 2863021 gcattatatg cgatacgttc tgaacagcaa agaacaaagt aaaaaacgac ctttacgaag 2863081 aggtcgtttt tgatttttta atcactattt ccacacgccg attttccttc atgtgttcat 2863141 ttgtcttgtt atcctttact ggctttgtat ccgcataacc gacagcaata aagcgcttgg 2863201 agggaagctt ctctttagac gtgaagtatt gaatcactcc acttgcccgt gctgctgata 2863261 gctcccagtt cgacgggtat cggtatgtcg aaatgtttcg gctgtctgta tgtccctcaa 2863321 cctgaatgtc atttggaatt gtttgaagaa gaacggcaat ttggtgaaga agtgtttcgg 2863381 catttttcag cacctttgcc tcacctgtat caaacagcac agcctcctga agaacgagca 2863441 cgacaccgcg ttcatcccgt ttggctgtca tttgggcctt caaatgattg tcttttatat 2863501 atgtatttac tttcttgaga agctgatcct gctgatcctc ttgcttcttc gtatcagatg 2863561 gggatgtatt ctttttttct atggatgttt ggtccggctg aagcccgttg ccttccttct 2863621 ggatcgagtc cactgccgct ttgaattttt gcagatcgat ttgggacatc gaaaagagta 2863681 aaataaagaa cacaaggatc aaggtgatca gatctgtaaa ggttaccatc cagctggatg 2863741 aagattgact gttttttccg cttccattcc ttctttcaaa acgttctctt ctaagcttca 2863801 tgtacagatc ccttttttgt ttttacttgt tttggctgct tctgccattc ttcccgtgag 2863861 ctgaaaacga ccagctggct ttcaaggttg cgcgggtttt ttccggattg aacaccgata 2863921 atcccttcca ccattacctg cttgatgaaa atttcacttt ctgttttctc ttcaagctta 2863981 gccgcgatcg ggttgaagac catatttgcc agtaatgaac catataaagt cgtcagaagc 2864041 gcaatggcca tgtttggtcc gagcatatgc gggtcgttta agtttttgag catcagcaca 2864101 agcccgacga gtgttccgat cattccccat gccggagcga attctcccgc tttttcaaaa 2864161 actcgccgcc cttttcggtg ccgttcctcc attgctgcga tttctgaatc catgacgagc 2864221 cgaatcgttt cttcatccca gccgtcaatc gctaaaagca gccctttttt caagaatgga 2864281 tctttgattt cccgagcctg atcatccaat gataaaagcc cgtgttttcg cgcgtgatcg 2864341 gaaagggaaa caaaggtttt cacaagatct ttcacattgt cttcctggcg gatgaatgcc 2864401 tgctttaaca cagagggcgc ttttttcagc tcacttggcg gaaaactgat aaaaacagcg 2864461 gcgcaaagtc cccctgttac gatgaagaaa gaggtcagat caagaaaaga gcggaaaccg 2864521 cttactcccg atcctgaaat aatcccgata acaataataa tcgttcctaa cacaaatcca 2864581 acaggtgtaa gataatcaaa acgtttcatc atttctcccc atgaaaaaag caagaattca 2864641 ccataaaggt gaagcttgct ctttgttttt cttatgactt ggttgacttt ctaagctcta 2864701 tacggtgcgg cagttcgacg atatgctctt caaccggctc tttattcatg agcttcgtca 2864761 gcagtctcat cgcaacggcg ccgatatcat atgtcggctg aacaactgtt gaaagctgag 2864821 gacgaaccat gaggcttaat cttgtattat caaaaccgat aatgtcgaga tcctccggaa 2864881 tggataagcc ctgatcctga gcggcatgga taatgccgag tgccatttca tcagttgcag 2864941 aaagaatggc tgtcggtttt ttatccaggc tcatcagatg ctgcagtgct tcgagtccgg 2865001 aatcatatgt gtaatcccct tcagctacaa attgttcatt aaacggaagg ttcgcttctt 2865061 caagcgcacg tttgtagcct tggagttttt tcgaacggtt gatcggttct gccattggtc 2865121 cggaaacgaa cgcgatgtct gtatgtcctt tatcaaccaa aagcttcacg gcatcataaa 2865181 tcgcctgttc gtaatcgata gcgactgacg gtgtttcctc ctgctcttct acagaagcgg 2865241 caagtacaat cggcactgga gaacgcttaa attccgccac atgctcgtcc gtaatgtttc 2865301 cgcccataaa cacgatgccg tccacttgtt tgccgagcat tgtgtttaac aagtgcagct 2865361 ctttctccat gttttggtca gagttgctca aaataatatt gtatttatac attgtcgcga 2865421 tatcttcaat tccgcgcgca agctctgaat agaaaatgct tgagatatcg ggaatgatga 2865481 cacctacagt tgttgttttt ttacttgcca gccctcttgc caccgcgttt ggacggtaac 2865541 cgagacgttc aatggcttcc aagacttttt tcctcgttgt cggttttaca ttcgggttgc 2865601 cgttcacgac acgggaaacg gttgccatgc ttacattagc ttctctcgct acatcgtaga 2865661 tcgtaatatt gctcatccta aaaccactcc ttttactgga tacacttatc cttatctata 2865721 gcataaacac tttatgtaga gaaatgtcat aatgtccgaa tttatgtcgt ttatgatttg 2865781 taagcgtaag tcagtagtgt acattatttt tcattattca tcaaatttaa ttacttctca 2865841 tgaaattata cacgttttta tagatgatga aaacgtatac ttggttttta taactaaata 2865901 aacgagaaag cataaaaaaa ggccgcaggc gcggcctttt ggattgttca attaagcgtt 2865961 gactttcacc attggcttca gttcattcag ccatttttcg aattcaggaa tcgccatttg 2866021 ctgagcagag tcagaaagtg cgactgacgg atcagggtga acctcagcca ttacgccatc 2866081 agcaccgatc gctaaagcgg ctttagctgt cggaagcaag aggtcacggc ggcctgttga 2866141 atgcgtaaca tcaacaaaga ctggcaaatg cgtttcttgt ttcaaaatcg gcacagctga 2866201 aatatccagc gtgtttctcg ttgctgtttc atatgttctg attccgcgct cacaaaggat 2866261 aatttggtca tttccttgtg acatgatgta ttcagcagca ttgatgaatt cagagatcgt 2866321 tgcagcaaga ccgcgcttca gaagcactgg ctttttcacg gcgccggccg ctttcagcaa 2866381 ttcgaagttt tgcatgttgc gcgctccgat ttgaatgaca tcaatgtagt ccagcgcttc 2866441 ttcgatatga gccggagtta cgatttcact gataaccgcc agatcaaatt catccgctac 2866501 acgttttaaa atttgaaggc cttcaacacc aagcccttgg aaatcgtatg ggctcgtacg 2866561 aggcttaaag gctccaccgc gcaaaatttt aatcccttgt tttttcgcag ctgcagcgac 2866621 ttcagctacc tgctcatagc tctctaccgc acatgggccg acaatgaatc tttgctggcc 2866681 gtctccgatt ttttcgcctt tgatatcaac aattgtatct tcaggttttt tcttgcggga 2866741 gacaagcagc gctttgctgt gatcttcttc ctgaagctct aaaccggctt tgaatatctc 2866801 tttaaaaatg tgctggatgg ttgaattttc gaacggcccg tcattgtttt caatgatatt 2866861 gtttaacatt gtgcgttctc tgacagggtc aaatcggttg acaccctgtg cttccttcgc 2866921 tttaccgatc tcttttacaa cattgccgcg ttcgttgatt aattttaaaa tttgtaggtt 2866981 taattcgtct gctttctgcc ttaaaagctc taactctgtg ttgctcattt ttttcatcct 2867041 ttccctgcac attcattttt tattttgtag ttatcatgca tcttactata agtaattcca 2867101 aatggaaata ctgaaataca aaaaatttta taaaaactct actttattac ccaaacgctt 2867161 ttaagtgata aagtaatcta tgaagctatc ctacatgatg tgagggcaat gttcaagggt 2867221 tttttacaaa aaaaagcgcc agatgatatc tggacgcttt tttctatgac aaatgctgct 2867281 caatagcggc ttctgtaatt tgtgaatgtg aggtatgcca tttcacttca ccgttctgga 2867341 tgatgaatat ctgagggctt tcatgcttga ccccatatgt ttctgcaatg aaattggaca 2867401 gcggccgggc ttcttgtact tgaagatagt aagccggcac atcctcatgc tgatttgcaa 2867461 aggcatcaaa ctcatgaaat gctgcctggc tgatcgggca tgtggtgctg tgtttcaaga 2867521 agacgaaaac gccttcctgt tctgcaatcc gtttaaattc ttcctcagat tgaataagct 2867581 gtttagccat gactcaagct cttccttccc tgctcagcga ttcaactgct cagcctgttt 2867641 ttgtgcatct ttcagttcgt cttttacatc ttctttcgtc tggaggactt gatcttttgt 2867701 ttcatcagct gcctgcatcg cttcttccct catatcttgc attgcagtcg atgaatccgt 2867761 tttgtcagat ttggaacggt ctctcaaatc ctttaccttg ttcatgatct gtccagactg 2867821 atccgctaca agctgtgtga tgttggaagt tttgtctttt gcgatgctga catattgcgt 2867881 gcctttttcc ttcgcatctg ccgtcatttt atcagttttg tcccgtaagg caacagcctg 2867941 gctgccgaga tcgtcgcgaa gttctttgcc tgatttaggc gctagaaaaa gagctgtagt 2868001 ggcaccgatg attcccccga ttaaagttcc gattaaaaaa tctttactat taattccatc 2868061 tttgctcatc attattcctc ctcttagtat ttttttctct tacagggctg attttttctt 2868121 ttgcttccat ttctcccaaa tttccattgc tgcttgactc caagtgacaa cttgattgat 2868181 cttatcttga ttctctctaa ctgatgccga tacagaccct gccgcttgtt tcatggatgt 2868241 attgaactgc tgtacagaag ctcccactcc ttgaacagca tgaacgaccg tgttcagctt 2868301 ttctgatttt tcctgaatat cttcagccag gcggttggtc ttatgtaaaa gctcggctgt 2868361 ttcagttgtg atgcccttca tttgtccctc cagcccttca agagtggatg cgacgttttt 2868421 tagtgtcagc tgcagtgact tcaatgtttt agacaagtag atcactaata cgagaaatgc 2868481 aactgcgatg agtgcaacgc tcaaataaag aataataatc atctcaaacc tccttgctgc 2868541 aggatatact gctgtttacc cgttttcttc aatcataaac atgtgtactg ggctgtatac 2868601 atactattct ccgttatgta agaaaatcct ttaataagct ttcccatcag ataaataaaa 2868661 agcagtgaga tcactgcttt ttattatgcc atgacgtttt cgtaggctct catatatttt 2868721 tggatatctc ctgctcccat gaagatgaga acggctttat catgagcttt taaaacagat 2868781 gtgtcatctt cttcaatcag cttggcatta tgaatttttc cctggagatc accgatcgtc 2868841 agctttccgg cattctcacg ggctgagccg aaaatatcgc ataaatacac acagtcggcg 2868901 ccgctcaggc tttctgcaaa ttcgtcaagg aactgctgcg tccgggtaaa tgtatgaggc 2868961 tggaataccg cgacaatttc ccgatcagga tacttctgtc ttgccgcctc gattgtcact 2869021 tttatttctg tcggatgatg ggcatagtca tcaatcagca cttgatcccc aagctgcttc 2869081 tcattgaatc tgcgtttgac gcccccaaag gatttgagag catgcttaat gatgctggaa 2869141 tcaatttctt cataatggca taacgcaatg accgccaatg agtttaatac attgtggtgg 2869201 ccgtacgcag gaatataaaa cgtatcatag aacgtattgc ggacaaagac atcaaaagtt 2869261 gtcccttccg tgctttttac gatgtttctg gcttgaaaat cattttcttc ccccgtgcca 2869321 taatacacaa ccgggacgtt cgcatggatt ttcggcagat gctcatcgtc tccgcaggca 2869381 ataatgcctt tgttgacttg aagagccatc tcttggaaag cgtcaaatac atcgtcaatg 2869441 cttgagaagt aatcagggtg atcaaaatca atattcgtca taatcgcata atctggctga 2869501 tagcttaaga aatggcggcg gtattcgcac gcttcaaaca caaagtattc gctgttttca 2869561 tttccctggc ctgttccgtc tccgattaag aaagacgtcg gttttgcgtt ttggatcacg 2869621 tgagccagca gacccgtagt cgacgttttg ccgtgtgcgc ccgtaacggc aacactcgtg 2869681 aattttttca tgtagtcgcc taaaaactta tgataacgta tcaccggaat tccctcagac 2869741 atcgcttttt ctatttcagg atgcgtgtct gggaatgcgt ttccggcgat gactgtcatg 2869801 ccgggtttaa tattttccgc gctaaaagga agaatcgtaa tatttctttt ttcaagcgct 2869861 gtttgcgtaa aaataaattt ttcgatatcc gatccttgga cagtatatcc attatcatga 2869921 agtatttggg caagcggact cataccggtc ccttttattc caacaaaatg ataaacagtc 2869981 ataattgtac ctccaacaaa cgtctatctg ttccccagta tatgacgctc atttcaattt 2870041 gcgaccgcgg cggctgaaaa gcctccctta gcggcgtatt ttatatgttt tgttatgttt 2870101 agtatcaggt tatttctttc cgattaaacc cagatatcaa gatttgtcta tgcacagctg 2870161 ctgtaaagcg gcatagctgt taaatgctct aaacactatc ataccatgtt tggtgtgaaa 2870221 atgaacccat attattcgtt tattaaatca cttgctgtga tcagcacctc tcgaggcttg 2870281 cttccttttg cctcagagat catgccttcc gcttccatca tgtcgatcag ccttgccgca 2870341 cgattgtaac cgattctgaa tcttctttgc aggcttgaag tgctcgcact gttttgctct 2870401 acaacaaact cacacgcttc gtaaaacagt tcgtcctctt ctttcagggc agatccttgt 2870461 cttacgagct cttcttgttc aaataaatag gtcggcggca tttggcttct gacgtgggaa 2870521 acgacgcggt cgatttcccg gtctgacaca aagttacctt gcagacgaac cggttttccc 2870581 gagccgtttt ccaaaaagag catatcccct tttccgagaa gcttttctgc accggctata 2870641 tcaataattg ttcgggaatc aacctggctt gagacagaaa aggcgattct cgttgggata 2870701 ttcgccttaa tcagacctgt aatgacatcg actgacggac gctgagttgc gacgagaaga 2870761 tggataccgc acgctctggc tttttgggcg atccgcgcaa tgctttcttc cacatcgttt 2870821 ggagccacca tcatcaaatc tgcaagctca tcaataatga caactaaata cggcagcttt 2870881 tcacccattt ggtgttcagc ggttaattga ttaaagcggt caatgtcgcg gacacctgaa 2870941 tgggcaaaaa gctcatagcg gcgctccatt tcctcaacga cccatttcaa agcagccgta 2871001 gccgctttag catcagtaat gaccgggctg acgaggtgag gaattttatt gtaaggggcc 2871061 agctctacca ttttcggatc aatcagcagc acctttacct cactcgggtc agctttataa 2871121 agcaggctta ctaatattgt attgatgcat acgctttttc cggagcctgt agcgccggca 2871181 atcaagccat gcggcatttt cttcaagtcg ataacaacag gatttcccga aatatctaat 2871241 cccagcgcag ctgtgagcgg tgacttgctt gtcctgaaag ctgagctgcg aatcatttgg 2871301 cgcaaatcaa ccaccttgct cgtgcggttc ggcacttcaa ttccgatcgt gtttttcccc 2871361 ggaatcggcg cttcaatccg aatatcttta gctgagagac tgagtttaat atcatcggac 2871421 aagttggtga ttttattcac ctttacaccc ggttcaggat gcacttcaaa tctcgtgaca 2871481 gacggaccct gggttacatg gaccacattg gcgcggacat tgaaattttt caaggtcaaa 2871541 tcaagaagct gacgctgttc ttcgatccac gcagtatcat cttgaacctg cgctggcggg 2871601 acatcaagca gtgcaacatt cggaaataca tagctgccgc ggcgctcctc tgctttttgc 2871661 tgtttatgcg tatctctttt cagcatcatc acattaaaag gaacggatgg ccctttttga 2871721 gaagatgcgc tttgttcagt ccttttctcc tgtacaccag gccttttttt cggctcttct 2871781 gaagcttcgc gaggtttgtc tgcgcgaatt tcctgccggt tttcaagagt tgcagtagac 2871841 gatttggaac cctgctccat gtgttcagtt ttctcaagct ctgtatggct gtctggctga 2871901 acatctatct tcgtttcctg agcctctccc agggtgtcat aatgattatt tattatgctt 2871961 tctgatggct cttctgattc ttttgccaca gtttctgctt gagccagagc ctctgatgaa 2872021 tactcatgat cagtaaataa aggctcttcc tgacgaatgt ccatttgttc ttcttgaacg 2872081 aacggggact cagcaccttc tgccgcgttt tcatgatgat tgtatactgg gctgtctgac 2872141 ggctcttttg ctttttcatc ctcagatact gcctctgtct gagattcagg agctgtttgc 2872201 tcttcatcaa gttcagcgga gaaaacaggc tcttcaaatt tctctggctg ctgctccctt 2872261 tgttcttcct cagccgttgc aggctcttcg cggcctactt cactgtctga aagcccttca 2872321 gccgccgtat ctgtgagcat ctcaggcggt gtttgctctt cggcttgttc agctgggaag 2872381 aaaggctcct ctttttccgg ctgttgaacg cctgactcaa atggcacttt gttacctgac 2872441 ggctcggctg gccgtttcgc cagcgcctca tcatgctccg tatcctttct gtttaaaacg 2872501 ccagaaggct gtttttcaaa ttgggtatcc gggaagaaag gactttctat tttggaatgc 2872561 gcctgtgtgt ctgaagcagg atagccgcgt tcacgttcga tctcttctga cagcagtgtt 2872621 accttctctt ttaccgattt atccggttcg ttcaatgttt cagaaggctt tttcggcaca 2872681 tcctttttaa cagatggttt ttgattgaat ccatagacag gcgaagggat atttgtcggt 2872741 ttaaacggtt tcttcgccgg ctctgctgct tgatatgtat gctgctcttc ttcatttctg 2872801 ggacgctctc tgtaaggtgc agcacttgga cgaggcgcgg atttcggttc gtccgatggt 2872861 gtgcggcgcc ttctcaggtc atgatttttg tatccgtcag gcacgactgg aaaacggaat 2872921 ttgccttttg gatattcata atatatttta ggatcttcca atctttttaa ttgtccttca 2872981 ggatgatgta cttcttgttg ctgcggaatt tgagcgggtt ttgtctcccg ttcagcatcc 2873041 tcttcgcttt cgcctaaaaa caaatcaaaa aatttatgaa gccaactcat aatttatctc 2873101 taactccctt atagttttct gggacggttt ttagtatacc actgctggtc ggcccagaaa 2873161 agattaagct atcagcagaa acaaagccgc taaacaaggg cttagcggct tttcacatga 2873221 ttcgtttttt ttggcggatt tatgggagtc taaaactgaa atgcgtctcc cgcctcatag 2873281 tctccttcta acacaaggat tcctttttca gcaggggcat ccggcaaatc aagctctttc 2873341 gctgagcaga tcatcccgct tgacggaacg ccacgaagct ctgcatcctt aatgacaagt 2873401 ccgctaggca tcacagcacc gactttggca acgacaactt tttggccttg gtcaacgtta 2873461 ggcgcgccgc agacgatctg aagcgtttct tctcctacgt tgactttaca tacgcttaat 2873521 ttatccgcat tcggatgttt ttcttttgat tctacataac ccacaacaaa cttcggagat 2873581 aaatcaacga ctaatgtttc ttcaacgccg tttctgttta aaatctcatt cacatcttgc 2873641 acgaatgttt ctgagagcgc aacagggccg ttttcatcaa tggtcaagta agaagacgca 2873701 ttgaaaatgt tgaagcccgt tgtttctttt gtttcgttat tgaaaatttt gacgacgtcg 2873761 ccgtgttttt catagcctaa ttgttcgcgt gtcacatctt gaagagagat caggagcgtg 2873821 tctcccacac cttctttatt ataaaaagcg ttcataagta aaaatccttt ctaatccttt 2873881 ttcggacggc ttttcgccag gataaacacc ggttccagct ttccttcatt gtacaaaaat 2873941 gatagggcgg taatcgggac ggtgccgcct gcaaagaagc tcatcgacat ttgtcctaga 2874001 atatcatacc ccgattcatt ccggatgtca gcaagaatca aaacgtcctg atgaggaaca 2874061 gagatcgcca gctcaccttc tgcatgctgc ttatactcat ttaagatcgc ttcgttcaaa 2874121 atccggcttg cgtcgtatcc gtcgtttgcc ctgaagaaat aaaagtaatt gccggcaacc 2874181 gtatcctctt tgacaaccgt cggcagggaa cggagattaa atgcggccgt ctctctgatc 2874241 cgctcttttg tccagttttc tttctcaagc atgcgctggt caattaaacg gtaggttttc 2874301 ccgagatcta gcgcgtaata aattcttgtc tctgcggtat gatcgtcata aatgagcggg 2874361 atatcttcgc tggacttgtc cgggaaggaa gtcgagcgga tgaccggata aatgcgagtt 2874421 tctttcccgg tcatttcctg agccttccct tccattgccg tcatcgcttc ggagacatag 2874481 tacacgatct catcaatggc ttcgtctttt ttcagttccc attttgcaat aatcggcggc 2874541 aaatcgagtg taatcccttt tttagtcgtt tgatcctcaa cacggagggt gtctttttct 2874601 ctgtcaaaca gaaaggagcg attctcgtgc tgaaggcgct gcttcagtat atctgacagc 2874661 ttccttgagg tcattttcaa accgatgtcc tcctttacgc tttagcgaga gagtctgtta 2874721 aaaactgttc aatttcttct tttgttttgc ggtctttgct cacaaaacga tttacttctt 2874781 ttccttcatt aaacaccaca aagcttggga ttccgtaaat ttcccactct gcacatgtat 2874841 caatgaattt gtcacggtct acgtagtagt aggtgaattc agggaaattc gcttccagtt 2874901 caggcaggaa aggctctaca aaacggcaat ccgggcacca atcggccgaa aacataaata 2874961 cagaccaatc atcctttacc gctttttcca gctcttgagt tgattcaatt tttttcattt 2875021 catatccctc cagttgttta tgttcttaca tgttttttat cgatactcgt ccatttggat 2875081 cataccaaac tgcttgaggc aaaaccactt atatgcaacg aatgaatatg taagattggc 2875141 tttcccatta tcattatcat attttatttg cattatcaag ctcgtttcgt ttaacatcgt 2875201 gtacatgagg gtgaaattta cagatggata tacataagga gggattttta ttatggagtt 2875261 tatcgtctat ttagcaggag aaatccacag caattggcgc gaggaaatta aagaaaaaac 2875321 aaaatcactg aagctcccga ttacgtttgt tggcccgatg gagaatcatg accgctcaga 2875381 caatattggt gaagaaatta tgggcgtaca gccaaatgcc gttttaaagg atgacaaagc 2875441 ctctgacatc aacaacttca gaaccgccgt cctgatgaat aaagcagact ttgtgatcgc 2875501 cctgtttggc gaaaagtaca aacagtggaa cacggcaatg gatgcatcat atgcgatcgc 2875561 aaaaggaaaa cccctgatta tcatccggcc ggaatcgctc caccatcctt taaaagagct 2875621 ttccaataaa gcgaatatta cggttgaaac cgttaaccaa gccattaagg ccctttccta 2875681 tctatttgaa acagaataag aaaaaagctt gtcgatccgg gcttactgct cgttcaacaa 2875741 gcttttatga aacctacata ttttctttaa tcgcatccac tgtctgctta tcgcaggctg 2875801 ttacaagttt gatgagcatt tctttagcag cagcataatc atcaatatga atgatagtag 2875861 cgtttgtatg aatatagcgg gaacatattc cgataaccgc tgacggcaca ccgctgttcg 2875921 aaatatgaac cttgcctgcg tctgttcccc cgccggatac aaaatattga tatggaatat 2875981 catgcgtttc agccatatca agaacgaatt ccctcattcc gcgatgcatg actgtcgttc 2876041 tgtcaagaat gcgcagcaaa aagccttttc caagctggcc gaattcattt ttgtctccgc 2876101 tcatatcgtt tgccgggctg gcgtcaaggg cgaaaaacaa gtccggttta atcatatgag 2876161 aagccgtctg cgcgcccctt agccctactt cttcctgaac cgttgcaccc gcatagagtg 2876221 tattcggaag ctctttaccg tgtaattcct tcagaagttc aatgcttaag ccgcatccat 2876281 atctgttatc ccatgctttt gataaaattt tcttttcatt cgccatcgtc gtaaacggac 2876341 aaacaggcac gatctgctgt cccggtctaa tgccgatttt gatggcgtct tccttatcat 2876401 ccgctccaat gtcgatcatc atgtttttga tatccatcgg tcggtttcgc tgcgcatctg 2876461 tcaataaatg cggcggtatg cttgaaatca cacccggaac cggcccgtta tctgtttgaa 2876521 tttcaacccg ctgcgcaagc aaaacttggc tccaccagcc tccgagcgtc tggaatctga 2876581 gcagcccgtt gtctgtaatg gatgtcacca tgaagccgac ttcgtccatg tgcccggcta 2876641 ccataattct cggtgcgtcc tctgcgcctc gtctgactcc gaaaacactt cccagtctgt 2876701 cctgaacgat gtcatctgca tatttggcta gctcctgctt cataaaagca cgaacctgat 2876761 gctcattgcc cggcgcgccg ggaagctgcg tcagtgtttg gaaaagcgct ttcgtttctt 2876821 gattcatgtt ttcccctcat ttctatgtag tccttttatt ttattagaaa caatgaagtt 2876881 ttccaagcac tctgacccaa tctgctcgat cagccgcgta ttgcttaaca ggatttggct 2876941 gtttctgtat aatgaaaagt acgatcaacc aggaggtgct ttattttgaa attgcgtcat 2877001 cttcttttag gagcaggact tggaatttgt acggctgtcg ttgtgagaca atatgtgatg 2877061 aagccttata tttcttcaga aaaagcgctt cgaattgtaa aatctgcttt taagcagcgg 2877121 ggcccgattg acggatcatg gatttacacc cagccggagc cctacaatat taacggagaa 2877181 acggtacagg tatacaaaac cggcattaca cgatcagctt tcggagaatt agaacagtat 2877241 gaagtcatgg tggatgcgaa aacgggagaa attgttgatg tcattgatac aatcgcctct 2877301 taacaccgga caagcaaaaa atagaagccg ctgcctatgc agcggctctt ttttattata 2877361 tcgcgcgaat cggtttgtat accggatacc acatcgcatc ctgcactgcc tgtataatgt 2877421 cttcaggctc ttccgtagcg acgccttcct tcattgcggt ttttgcaact tcaacagcaa 2877481 cggttgccga aacagtgcgc aaatcttcaa cttttggaag catcggcgcc ccaggcaccc 2877541 cgacattgac catacctgcg attgcccggg cacatgcttc aaacatgccg tcggtaatta 2877601 attttgattt tgtaacaatc gttccaagac cgagaccagg gaagacaagc gcgttgtttg 2877661 cctgcccgat atgatacgta actccgttat attcaactgg cgggaacggg cttcctgtcg 2877721 tgatcagcgc acggccttct gtccattcga ttaaatcctc cggctttgct tcagaaagag 2877781 ttgtcggatt tgacattggc aaaatcgccg gccgtttcac atgtgacgcc atttctttta 2877841 caatttcttc agtgaaagcg ccggaaaccg tagatgtgcc gatcaggatc gtcggtttcg 2877901 cctgccgaac cacttcaaga agatcaatgc ctccgccgtc tccgttccgc tgataatcct 2877961 tcacttcatc agccgaacgg gcatacggct tttggaaatc aagaagctga tccatatcat 2878021 ctgttaacag cccgttcctg tctatgcacc agaagcgctt gtatgattct tcttcactca 2878081 gtccctcgcg caccaatgct tcccgcagct gttcggcaat tccgattcct gccgttcccg 2878141 ctccgaatat aacaactctg tgatctctca gcggaacttt agacgctttt gcacaggata 2878201 agactgcggc caaagaaaca gcgccagttc cttggatatc atcattgaag gtacacactt 2878261 tatctttata gcgtttcaaa atgcttcgcg cgtttttcgc cccgaaatcc tcccaatgca 2878321 gcaatgcatt cggaaatgtt tctctcgcca gcgcaacgta gtcgtcaata aattggtcat 2878381 aacgttcccc gcgcactctg gaatgctggt tgccgacata aagcgggtcg ttcaagaggc 2878441 tctcctgatt tgtccccgca tctaaaacaa cagccagcac tctgctcgga tcaatgcccg 2878501 cagccgctgt ataaaccgcc agcttgccaa tagaaattgc gattcctccg acgccccagt 2878561 caccgattcc taaaattcct tccgcatcag ttgcaacaat taaatcgatc gtatcgcttt 2878621 gatctttata ctgtttaaaa gcttctttca taccgtccgg gtcatcgatt gacagataga 2878681 gccctcgtgg ttttctgtat tcatggctgt atctctgaat tgccgttccg actgtcggtg 2878741 tgtagacaat cgggagcatt tcccctaaat ggtcatttaa caggcggtaa aacagcgttt 2878801 cattccgatc gtgcagcgcc gttaaataga catttttgct caaatcgtca ggctgtgcgg 2878861 aatattgttc atacgctctt ttcgcctgat catcaattgt taataccttg ggcggcagaa 2878921 agccttttaa accaagttct tttctttctt cctcagtaaa agcaacacct ttgttcaaaa 2878981 aaggaacaga gagcacttca aggcctctta atgttgtttg aatgtctcct tcgtttgtta 2879041 ctctgaattg tttcaccctg cctcttcctt tctgagcata atagtactag gtttgcatta 2879101 ttagccggaa aacatgcagg gtaaacataa aaatatgcta tcgcttcatt cgcttaactg 2879161 actttttgat gcttccgtcc tcctcccatt gaagggcgcg atactcggca tcatggtaaa 2879221 aaataaacca agcatctttt tctgctgcga acgcctgcca tttctgcttt tgcgggatag 2879281 aggtcatcgg ataatcatcg taagccagca cccatagcgg attgcggtgg gcatgtgtcg 2879341 gcatcagatc tgccatatgt acggcagttt cacccgcatc ctcgcatatc aggacactgt 2879401 gtccgtcgct atggcctccg gtgtgatgca ttgtaatacc ctctgtgatc gttaaggtgt 2879461 cttcaaaggt tttgacttgg ccagctacag cctcccaatt ttctttccaa tacgtatttt 2879521 tcgacctgat attcggatgg cgcatttcgt cccattcaac agctgatgta taaatcactg 2879581 cattcggaaa gacagagacg agccgttcac cttcatattc cgttaaaccg catgcatgat 2879641 caaaatgaag gtgtgtcatt gcgatcacat ctatatcggc aaccgttaat ccgagtgcag 2879701 ctaatgaggg tttcacattc gactcttgtg tcacgccata gtttcgtttt tgtttatcag 2879761 tcagcttgcc gtacccaatt ccggcgtcaa tgatgatatt gagcccatcc ttttgaatca 2879821 aaatagggtc tgttcttagt tcaatctggt ttttttcatt gactggatat tttttagacc 2879881 aaagcggctt tggcacaacg ccgaacatgg cgcctccgtc catatgcgtc acgcctccgt 2879941 caagccaggt caacgtgatg tttccaattt tcattgtttc cattttcacc cccccctatc 2880001 atcatggtag caaacggccc ataaaaaaaa cagactcctg tcagagtctg tctttacgtt 2880061 ctccattcaa cctcagcccg atagatcggc tggccgagtg cagagaattt ttcttcatat 2880121 tctgtcataa tattgccttc cagattgctg ttatgcaaat cgagactgac gtatgtcagc 2880181 aggaggccgt actcagagaa gctcttcaaa gagtactcaa ataaacctcg gttgtccgtt 2880241 ttaaaatgaa tcgatccgcc tttgcccatt acttcttcat attttttgag gaagtgggaa 2880301 tatgtcaggc ggcgtttttc atgccgtttc ttcggccaag gatcagaaaa gttcaagtag 2880361 acccgtttca cttcccccgg ctcaaacaca tccgtcagcg tgtccgcatc tatattcaga 2880421 agctttacat tctgcgcttc gctgtctttt actttttgga cggctgtcac gatgacgctt 2880481 ttaaataact caataccaat ataattgatg tcgggatttt gtttggccat accagaaata 2880541 aattggcctt ttcctgtacc aacctcgata tggatcggat tgtcgttgcc aaacactgtg 2880601 ttccatttcc ctttataatc agcaggattg ctgatggcaa tatctgcgtt ttcagccaaa 2880661 aagtcatcag cccaaggctt gtggcgcatt ctcatatgat tgacacctct atctattatt 2880721 tcgactaaca acataccatg aattaaaaag acccgcaagc tcgtttttcc agtgtatctc 2880781 tcttaaggcc gagcgcataa aaaaagaggg tcccgtctgc tggaacactc ctttcccatg 2880841 tataaaaacg ctctgttttg aacaatttaa cccgtatgat actgaaggga tgtgtaccgt 2880901 tatgggttta cattatgagc atcaagttca tttattgaag gatatattga ctgaccatca 2880961 attggactgc tgcggaacag tcgcagagta cgagcagctt gagcgtgtga ttaaatcact 2881021 gatggcaaac accgagcttg attcaaattt caaaaacgtg cttgaagatg tttaccgcta 2881081 cagccaatca ggaatatcgt ccaaatccat cgactcacac atacaagagc atcagaacag 2881141 cctgtctcaa tgggtagagc aaatggattc gtattcctga ttaatcaaca attcgtttca 2881201 tgaggatatg cagctcttcc attgcatcat gaaattcctt atcattgcct tttgctttat 2881261 gccaggcaat gaaagtaatt gtttcagata acacatacca agccattcgc aaccgaaggc 2881321 tttctgtcag ctctatgccg tacatgctca gccagctctc ccaagctggc ttttcgacgt 2881381 agtggtacag caaaggcccg aggtccatcg ccggatcagc gatcatggcg ccgtcccagt 2881441 caattaaata cagctggttg tcttcagaca atagccagtt attatgattg acatcacaat 2881501 ggcaaacgac tttctcaccg aaatgcactt catgcaggtg ttcttccaaa tacttgatcc 2881561 cttcttgaat cagcggcgaa gattgctgca cagcaaatac agcctgcttc agctgagaca 2881621 aaagagcccc cgggttcagc ggttcttttc caagtctctt cagcatgtcc agcaaggctt 2881681 ttgatgtgtg tattttacga agcaattcag caacgggccg tccgctcatg tctttaggct 2881741 tcagctctct gccggtcatc cagtgctggg ccgtaatgac gtccccattt tccatccgtt 2881801 ttgtccaaac cagcttcgga acaatgcctt cggcggataa aacagctaaa aaaggtgagc 2881861 tattacgttt taaaaaaagc tgctgcccgt tatgtttcgc ataatatgca tctcctgtag 2881921 ctcctccggc ggggaagatc tcccaatcgc tacctagtaa ttgtcccaac cagttcatat 2881981 caatgttcaa cccatcattt cttaaaatat tttagaatta aggctaatcg tttctagtct 2882041 atccagcgaa tgcctttttc gtacgaatcg tataaaaata aaaaagacag ctattgagag 2882101 tctcatatgc taatcaatag ccgtccttta aattttagcg ctatagcaca aacttcgtca 2882161 agcaaaactc ttaagatctg atgctaaata taagataacc gttccgatgc cgtttactgc 2882221 aaccgttttc ttgatttctg ttgggtcttc ctgaaatcct gatggatcac ataaaagccg 2882281 ataaggtatg tcgtttggca gcctccactc gacggagtct ggactcgcgt gatggataac 2882341 aatgatatct ttccattcgt caacctcgtc aagatcataa agcctgtatg cgataaggtg 2882401 ttcttttagc gtcaagcatt caagatggcg ctggatgtct gcagcggacc taagacggaa 2882461 tgcaggatgc gcttttctca gcgagatcag cctgcggata tagtgaacat cttctttgaa 2882521 tgtttcacgg cgatcccagt cgagctggtt gatgctgtca ctggattgat agctgttttc 2882581 cactccctgc ttcgtccgga aaaattcctg gccgctgtga ataaacggca ccccttgggc 2882641 aagcaaaata atcgcggctg caagcctttg cctgcttcgc tttcggctgt cattttcttg 2882701 aggaagcgca aagctcattt tatcccaaaa ggtgtgattg tcgtgtgatt cgacataatt 2882761 gatggactgg cttggttccg gaacaatcgg tgctaatgcc ttccatccgg aagacccggc 2882821 aattccatgc atcacagctt gtgctgattc accgttgccg agcgcaaacc ctgttgcctt 2882881 aaggtgaaag gtgttccctt ttacagcgtc acgaaacata tcattaaaaa agccgatgcc 2882941 cggcattctt ggcgcgttcg ccaaagcagc tttctgttca tgcggcagcg gtgtagccag 2883001 gtcccaccct tctccaaaaa gcaggattcc gggctttgcc ttagttgctt tctctttcat 2883061 ataaagcacg gtgtcaatat ctaaaatccc gaggagatca aagcggaagc cgtcaacatt 2883121 gtattcttca agccaataga ccacgcaatc cgcaatgaat tttcttgcca tccttctttc 2883181 tgatgcaata tcattgccaa cgccggtgcc gtttgatggc atcccacatt cgtcgtgccg 2883241 gaaaaaataa ccgggcactg tcttttcaaa gggggaattc tccctcttat acacatggtt 2883301 aaaaacaaca tccagaatga ctcgcagacc gtgctgatgc agggtattga tcatttgttt 2883361 cagctctgtt tttctcgttt gaggatcatg aggatttgag gcatagcttc cctccggggc 2883421 aaagaaatga agcgggttat atccccaatt gtatgcatca agcggcttct cttcatcaac 2883481 tccggcaaaa tcattcaccg gcagaagctc cacatgtgtc acaccaagct cttttacata 2883541 cgctaatccc gaagaactgc catttgcggt ttgtgtatca gtttccgtca gcgctaagta 2883601 ttttcccttg tttatcatgc cgctgttttc atggatggag aagtcgcgaa gatgcgtctc 2883661 atagatgacg gcatccacag ggtgtgagaa tggtttaaga ggagcagtcc atttcatttg 2883721 atccgggcgc aagacgacgc ccttctctcc atttacagtc acagccttgg catactggtc 2883781 aactgtttcc atccattctg aattgttgca gatgcaaaac aaatactcat atccgtgaag 2883841 gtcacctgtg accgtaacgg catagacgcc tttttccaag cgagtcattt ggaatgtgcg 2883901 cccgctttta ttggggtgtg aaagcttgac agcagctgag gttgcagcag gcgcccatac 2883961 tttaaatacg gtatgatccg cggtataaac ggcgcccagc tctccgtcat aataaaattc 2884021 gtcatcaaac gctgccgtcc ggatgaccgc gccaatttgg agatccgttt tgtggccgct 2884081 ggatgctctg acgcaatgga tttttccaaa tgtcacagga tggtcggata cgcagacgta 2884141 cttgtatttt gcttcaaggg agtattcctc cctgacagcc agaggaaaat ctgttatttc 2884201 tgtctcaagc cgaaacggcg gtgtcatgat ttccttttgt tcagcaggaa tcagaacagt 2884261 aatgatattc atgtcatcga catacgcttc gaagctgcgg cggatgctga ccatcggaag 2884321 ctctctcctc caaacacgtt tatgttttga ttcttagggg tgaaggacta gatgccagac 2884381 gaaacggggt agtgcccatg atttctccgt cagcatggaa cgggattttg tccttcgtgt 2884441 aaaatgtaat gtccttcgct ttaaacatcg taacgccatc catctttgta tgttttccaa 2884501 atgccatgag acataaaagc caatattttt tcaaaaacgg ctggttttca acgattacga 2884561 tatcaaatgt cttctcgcgc ggatttgcta ggggcgccgc cttcatgcct cccccgtaaa 2884621 acggatggtt ggatacaacg gcaaaccaga catcatgaaa ttcgcgcgtc tcgtcttccg 2884681 tcgtacaagc taatgtaaac ggcttaaagg ttgccgaagc gtgcaaatga gaaagcggat 2884741 acacaagaaa tcgaaggcgg agaaaaagaa aaacccgtct caacggaaat tccatcgcct 2884801 ttttattgac atatgcgtca aacccgatcc cgatatgatt cataaaataa agaatctgtg 2884861 atttatcctg aaggaaattg acgctcccta aatgaaaggt tcttgttaac gggcgcttta 2884921 ccttcttgat ttcctgtatc agatcgattt ttttaataga gaaccctcgc gaaaaatcat 2884981 tatacgcgcc cgccggcaca aagctcagct caatatcgtc aacatctttc agcccgttga 2885041 caacttcatg catggttccg tctccgccaa tgacgatcag gcgcttcagc ttatattcct 2885101 gtatcgttga aatctgtctg gcgagcacct cggcgtgtcc cggatgttca gttaaaaatg 2885161 aacggtgctc aacctttcgt ttgatcaatt ctttttgaat ggacttccaa acacgcaggc 2885221 cgtttcgatg tcctgctgtc ggattaataa taaaaaacca atggctcatc tttctcacct 2885281 gcttatgtta tgagaaaacc gctcaaatcg ttctctttta ctccagccac tcctgtctgc 2885341 gataggagtc agacatgcag taagacaata gagcctttgc agcctttacc tgatgatgtt 2885401 tgatcggagc agtgtttttc ttctgccgct caatccattc ttccgcgctc cgcttatccg 2885461 ctatttctaa gccgtatggc ggctccgggt aatcgatgta cgacgttctg ctcagaagca 2885521 attttcgaac cggaatctca gcctgttttt cctttacgat ctttgacaca accgagtccg 2885581 tacgaaacag gctaagccct ggatttaaca ctgatgcagt ctgagaggct gttttcttgt 2885641 cccaaaaacg atttttagac cctatgtaga cactgtcttc ctcagcctct aaaaaagaaa 2885701 cgcaataaat ttccagagga gaaataatca caatgcttaa ttcaaccgcc gcctgctgaa 2885761 ttttcagcac aggcttatac ataataaaat aagaatcagg cagctgctgg gtcagataac 2885821 gcaaaatgcg gtcctgcttc acttggtttg agagttgaga tatttctgaa agagtagagc 2885881 ttgcccattt gagctgaaaa tcatataaat gccttttata aaaagaagca agcgccaccc 2885941 tgctcttcgg gagccttaca tgaatatctt cttcgtcctc aaaccattgg tgtctctctt 2886001 cttgtatatc ggcttttatc tcttcttttc ttcttttcaa tgaaaatttt tttcgtttct 2886061 gcaccggttc cggttcttca gcactggctt gcctttcttc atgctggcgc tccgctgctt 2886121 ctactagtga aagccagcgc tcttttttca aacgtacaaa ctggttgata taatggtacg 2886181 gatcaagctc atatctcgat atataatcat gaattttgat gatttgtgcc atgtttgttt 2886241 ctccactccg caatgaatta agataattga aatttgaata tttcctcgta ttttggtgat 2886301 tggttcaagt gtatttgaaa gagcgaaaat cgttcagcca tcatcgaaac ctcgccgctt 2886361 tcaaacggaa catgagctgg aaatccatct tcgcctgtcc attttcttgc cagcgtcata 2886421 tgaggatgat acggtctttt ttccacttga aagccggcct gaagtacagc ctgcttcgta 2886481 tgttcccgca gtctatcaag cgttttgttt ttctttggct ccagatgtaa aacgcgcggc 2886541 tttctgcggt cgccgaatac atctatcttg ccaaacttaa ttgaaaatgg atcaatttct 2886601 gaagcaatct ctgctagcga accttcaagc ttctttattt gtgtctcatc cgccgctccg 2886661 agaaaaatta acgtgatatg atagtcaagc gggtgcaccc atttttgaaa cgtcaatatc 2886721 ggttcgtttt tcgcagcctg gtagatcgga tttgcaattc cctcaggtat gggaacgccg 2886781 atgaaataat gaggccgtat atctggcatc cgtctgacac tcccttcttt gacagctatt 2886841 attttatcaa taaagaggct gtgcggatag aggaacagtg tatgaaaaca ctctcgcaca 2886901 aacgtttatt atgttaggat attatatgac acttgtttta ttcagaaagg aatgacaatg 2886961 ttgaaaatcg ttgcaaacac agctgatctg ataggagata caccgctagt gagattgaat 2887021 cggcttcagc cggaaaatgc ggcacaagtc tatttaaagc ttgaattttt caatccgagc 2887081 ggcagtgtga aagacagagc cgcttatcaa atgatcatag aagctgaaca aaacggttta 2887141 ctcaagccgg gatcagttat tatagagccg acaagcggaa ataccggcat cgggctcgcc 2887201 atgaatgcgg cagcacgcgg atataaagca atcttagtta tgcctgatac gatgacgaag 2887261 gaacggatca acctacttaa agcttacggt gcagaggttg tattaactcc cggagaggaa 2887321 agaatgccgg gcagcatcaa aaaagcgaag gagcttgccg aacaaattcc gaacagctat 2887381 attccaatgc agttcgataa cactgctaat cctgatgcgc accgaaaaac aacagcgcct 2887441 gaaatcgccc gggcaataga ggaaatcgga aaaccgctcg gcgcttttgt agcctcctct 2887501 ggaacgggcg gaaccattac cggaacaggt gaggcgctca aagagctttt tccggatatc 2887561 acggttcatg ttgttgagcc agcgggttcg cctgtattat ccggcggaaa acctggcgcg 2887621 cataaacttg taggaacgag cccaggcttt ataccgccga ttttaaatga agacgtttat 2887681 gatgaaatta tcaaaatctc tgatgaagac gcgtatacga cgacaagacg gcttgctgct 2887741 gaagaaggaa ttcttgtcgg tccttcatca ggcgctgcct gcttcgcggc aatcgaaaca 2887801 gcgaaacgcc tctctcctga caaagttgtg gtctgcatga cagctgatac aggagaacgg 2887861 tacttatcaa ctgatttatg gtcatttatt taaaaaaagg actggcttca gcagaagccg 2887921 gtccttttat tttgcaagct cgtaaatggc ctgagcatat aacgctgtcg atctcagcag 2887981 gtcatcaatt tcgatatatt catccttttg gtgtgcgctg tcagggcgtc cggggaacag 2888041 cgggccgaac gcgacaccgg cttttaagga tctcgcataa gtccccccgc cgattgagat 2888101 taaatcagct tttttaccca gctggccttc ataaaccttt tgcagggttt tgactaacgg 2888161 atgatctgcg gacacgtgat gcggcttgct gtctttgaat tctcccagct caaattcaga 2888221 tgcgctttcg aatgtatcgc ggatcacttt gctttctgct gtcacaggat agcggatatt 2888281 gatcccgagc tcgcctcctt gcccttcttt atagcgcagt gttccgacat ttaatgtcag 2888341 ctctccgctg atttcatcct cacagtcgat gtccagtttt tttcctcttg tatcacctga 2888401 gaacttatct gtcacaactt gcacaaaccg ctttcctgca tcgtcaagct cagtctgctg 2888461 gagaaattcg cacaataaaa tgccggcatt gatcccattg ttcggttcca tcgcatggca 2888521 ggaaagaccg tacatacgca aaatgagctg tccgttctct attgcagctt cccctttttg 2888581 gtccgtcgtg cggagcatgt ctttaaatga agacagaatc tcttcatttt tcggcccttc 2888641 aatgacagct tccgcagcgt cgggcaccat gtttaagcga aggcctgatt gaaacgagac 2888701 aagcactgcc tttggttcag cttgatttgg gcggtgcgga ataagtaaag aagcatcgat 2888761 gatccctttt tccgcattaa tgatcggaaa atcggcgtca ggcgcaaagc ccattgttgg 2888821 catttcttca tgcttgaaat aatgctctac gcatctccaa tcactttctt catctgttcc 2888881 gataatcatt ctgactcgct tggacagggg caaattcatg tctttcacga ttttcagcgc 2888941 gtagaatgcc gccattgtcg ggcctttgtc atcaatggcg ccccttgcat aaatccgtcc 2889001 gttgcggatt tcagctgaaa atggatcact cgtccaccca tctcccggcg gcacgacgtc 2889061 aacatggcaa agtacgccga taatgtcatc gccctccccc cattcaatat gacctgcgaa 2889121 gccgtcaaga ttttttgttg taaagccttc tttttctcca agctccagca atgaagtcag 2889181 gctggcattt accccttctc caaacggttt accgggtccg gcggttgttt cgtccatgac 2889241 actgttgatt ctcaaaaatt cctgtgtatc acgaattaaa tcctcttttt ttctgatcac 2889301 ttcaacttcc cagttcataa tgatcccctt tccgcaagaa atgacttgca aaaaccaaat 2889361 aaaacgaata atattaatgg tgttttgtta aaacgttcgt aattggagga tactatgttt 2889421 catctaaaag agcagcaaac atccataaag caagaaatca tagcagggct gacgaccttt 2889481 ttcacaatgg tctatatcgt cgtggtcaat ccggtcattc tggctaacgc cggggttcct 2889541 ttcgaccagg ttttcaccgc aacgattatt gcctccattg tcggaacgct gtggatggcc 2889601 ctggcagcaa attatccgat tgctattgcg cccggcatgg gcttgaacgc ttatttagcc 2889661 tttcatgtcg taagcgcaag cgatggcggc atcacgtacg caacagcttt cagcgcagta 2889721 tttacagcag gggttctctt cattattcta tcgttaacgc ctttaagaaa acaacttata 2889781 gaagcgattc caaacaattt aaaatacggg atcacaacag ggatcgggct gtttattgct 2889841 tttatcggtt tgcgtcaagc gggaattgtg gcagctgatg agtcaaacct ggtcactctc 2889901 ggcaatctgc attcacctgg tgttatctta acgctggtcg gccttttgat cagcgtggtc 2889961 ctgatggtgc tgaatgtaag cggcgcttta tttatcggaa tggcagctac cgctttgatc 2890021 gcctttttca ccggtcagct ccatttttca aagggattta tgtcgcttcc tcatttgccg 2890081 gaaggattga tgatctcaaa tccatttacc gcttttggcg atgtcattca tcacggcctg 2890141 tacgctgtcg tcttttcttt tctattagtc accatttttg atacgacagg cacgatgatc 2890201 ggagttgccg agcaagccgg gctgatgaaa aacaacaagc tgccgaacgt gcgaaaagcg 2890261 ctgcttgctg attcaaccgc gacgacagta ggagctgttt tcggcacaag tccgacgact 2890321 gcatttatcg agtcttccgc cggtgtcgca gccgggggaa gaacggggct tacggctttg 2890381 actgtcgcgg tgatgtttgc ggcttcaatg tttttcagtc cgcttgtcag cgccttgtca 2890441 ggtatagccg ccatcacctc gcctgctttg attatcgtcg gcagcctgat gatgggctca 2890501 gtttccaata tgaactggaa agagatggac gaggcatttc ctgcgtttct cgtcattcta 2890561 gccatgcctt tgacctcgag catttctaca ggaatcgcgc ttggctttat ttcgtaccca 2890621 attgtaaaag cggcgcgggg aaaatggaga gagattcatc cgctcgtcat cgttttcgcc 2890681 attctgtttt tcatccagct gtttatttta taaggataga ccaaaaaacc caaacgtcgc 2890741 cgtttgggtt ttttatgtaa acaataaaga gacagcggcc gctaaaaaac aacaggcggc 2890801 aaacgcatag tgcaggatgt tgatacagct ttttctggcc cgataatatt catcactttc 2890861 cttatcggtg ccaattaaaa aaggggcatc catgaccttg tcaaaaataa gcgtcaggat 2890921 ataacggcaa acccctgtgt ataccagcag cgcaatcacc ttcagccaaa ttggggaaac 2890981 aaatatgaga acagtgaaag ctgacagtag catgtacatc tgccttgcat actcgccatt 2891041 cctcagcata actttaaaaa acaactcctt atagcctgtg cagatcgttc gtcttttaaa 2891101 tatccttttt gaatttcggt ataataatgg ttttcttctc atcctgtctt ttacttttgg 2891161 cattcccgcc tcctgactca tcatcatcac aagtcctgca agggcaagcc tgcttttttt 2891221 ctcttcagtc acctcagctt caaaagccgt gaacgaggct gtctttttca aactgcggat 2891281 aactgagaaa aacaaaaata aaatgccaaa aagcgcaagc aagtgccgct cagtaaaaac 2891341 aatcaggata gcagaaccag caaaaagaat agctctgaca agggtatcgc caatccatct 2891401 cgaaatggag cgcggctttc tgatcctgtc ttgctttaag gataaaaaga atatatgaag 2891461 gccaaacaaa taacacaata gagcagtgct ttctgcgaat gtgatgagaa cagaatgact 2891521 gatcaaggga aggacaatga aaaagagaag cagccattta gccagcgtgg ccagaaaaga 2891581 atacaaaagc gcataccgtt tgagctgata gatgatttcc ttcttttgca gcaaaaacac 2891641 tttgtccgct tccattaaaa atgtacgaat cgaacctgta aacatgatca gcacacacac 2891701 agcatacagc catctccatt ccgccacttc agaccactca taaagaaggc ctcttccgtt 2891761 catcaaatca atatactgat agatgacaaa agcaatcgcc ggcaaaacga tatagagagc 2891821 gactgtccag tcaatgaccg catgcaacac tttaaactga tacttataat agtcaaacag 2891881 ccttcgaaaa aagagcgtac gcccgttcat agccgatcac cttgaactgc cttataaaaa 2891941 cagtcaagca atgactgccc ctctaatccg gtcttgtcct gaacatcttt taacgtgcct 2892001 tggagaaata atgaaccttt ctcaatcata taaaaccggt cacagatttt ttccgcggta 2892061 tcgagtacat gcgtgcacat aagaattccg gctccacgtt ctttttcagc cttaagcatg 2892121 tccacaaagc gtttcgtcga tatcggatca aggccgataa acggttcatc aatcacatac 2892181 atatccggct tagagagaaa ggcctggata agcattagtt tttgctgcat gcccttcgaa 2892241 aaggtgacag gcagctcatg tttgacatga tctagcgaaa acgtctgcag caggctttgg 2892301 gcccgatgcg caaattcact ctcttcaatg ccgtgaagtg tgctgatcag atccaaatgc 2892361 tcccacagcg tcagttcttc gtagaaggac ggatgctccg gaatatatgc aaatgaacag 2892421 tcgttccagg caatatgccc tttaaaatct tctgaaaggc cgagtatcgc cttgattgcg 2892481 gtgctttttc ctgcgccgtt agctccgatc agtccaacca gttccccttt tctgacttcc 2892541 agaaaaacat cggtgagcac tttttttcgg cttgtatacc cggcctgttc tattgaagct 2892601 tcaagcaaat ttgtcaaaac tcactcacct ccaaaattta ctacgaaata gaataaaaaa 2892661 agtttcttta accataataa tattgagccg aaatacatag taatccaaca aggatggctg 2892721 cccaacgcga aattggaaaa aattaatagg agttatccct agattcatca ctgcaatatc 2892781 gtgtataatg agggcgaatt attttaacaa ttacagatgt ctgcctttgt tgctatttcg 2892841 tacgcagttg atagtcgtga gttgtggtta gtcaagtcca tccgatctta tgatagggag 2892901 tggttttttg aaaccttcaa caaaccgtat gctaactcga atcaaatcag tttacatgtt 2892961 tattcaagaa aaaggtcttg tgacaacaca ggaactggtt gacgaattcg gcattacacc 2893021 tagaacgatt caaagagact taaatgtgtt ggcatataat gatcttgttc atagtccaag 2893081 ccgtggcaag tgggagacaa cgagaaagaa agtaaagatt acctcataaa ttgaaaatta 2893141 catagggccg cctgagagcg gtccgataga taacagggcg aagaaactac tgagccttgt 2893201 ttttgtgtgc ttataaataa aaccccgcat tcggtatgcg gggtttttgt catgcttgcg 2893261 gctcatttag caaatgaagc tcttcctctg tcagctcacg gtattctccg ggtgccagag 2893321 cgggatctag ggaaacgcgt cccatcgaaa gccgcttcag ataaaccact tcattgccga 2893381 ctgcctttgc catttgcttg acctgatggt attttccttc tgtaattgtc agatatataa 2893441 cggtattgcc actgtcgttt gttttgattt ccgcttttgc cggctttgtt ttatagccgc 2893501 cctctatgta gacacccgtt tccaaatcgg aaatgtcttc ccgagaaatc tgtgatttta 2893561 aatggacttc atacgttttt ggaacatgct ttttaggaga aaggagccga tgtgcgagct 2893621 ggccgtcatt tgtgagcagc aaaaagccct ctgtatcttt atcaagcctg ccggctggaa 2893681 atggctcaaa tctcatctcc tccggcgtca gcagatcgac cactgtttgc tgccggctgt 2893741 cctcagtcgc cgacagcacg ccctgcggtt tattcatcat aagataaatg aactctcgat 2893801 aatcaaccgg ttccccgtat acggtcacct cctgcgtatc aggatcaacg tgctccttta 2893861 catctttggc aggtttgccg tcgatcatca cggctccagc cttcacaacg gctttgactt 2893921 cttttctgga accatacccg ctgttggcaa gcagcttatc aagtctcatt cccaatctct 2893981 cctttataaa agaaagcccg cagcatgcga gccctcagtt tcatcatatc tagttcatca 2894041 gcctgcatgt ctgcctttcc taaagaaacc tggcaaacgg cggcctaaaa ttttctgcaa 2894101 aaatcctaat cggtagccgc aatacaggta gacagctccg ccaacagcgg ccgcgatcac 2894161 cacaacaatc gcagcttgca tctggccatc ctgataggaa ataaagaagc ctaataccca 2894221 ctgcacgatt ttcacggcaa tacccataat ggctgataag accagcatca aaacagttcg 2894281 tttaacaagt atcttatacg aatagcctgc atggcgctta atcatgataa acccatataa 2894341 aagggaagcg atatatccaa gcgccgtcgc taaaatcgct ccgtcagcct gcatcagctt 2894401 gatcagcgga acattcagca caagcttgat cacgacaccg atcacaaggc tgacaaccgc 2894461 aaatttttgc ttattgatgc cctgcagaat agctgcgttg actgtaaaca aagagaacag 2894521 aattgcgaca ggcgaatacc aaagcaaaat gtttgccccc agttcaggat gaaggctctc 2894581 tgacccgtaa aagaacgtat acgtcggtcc tgacaataga gagatcccga caacagccgg 2894641 aataattaaa aacaggatcg tctgcatcgt ttgattaatc tgctgattta acagcttata 2894701 gtttccgctt gtaaacgatt cagtaatcgt tggaattaat gtcagtccaa aagcagttgc 2894761 tagggaaacc gggatcatca cgagcttctg aacatacagg gttagaatcg caagcatgtc 2894821 ctggctgatg gcttgatgac cggcttcaat catcgctttg ttaaacgtat ttgtatcaat 2894881 atagttatac aaagggatgg ctagtccgac aaaaacgtac ggagcagcat agctgaacag 2894941 ctcgaaaaac attttcttgt agcttaggtt tgctgtcgga cccgtattcg gcatcatcgc 2895001 cagcaggctg cccttccgtt tgttccaata aatataaagc acgaccagcc ctccgaaggc 2895061 accgatcagc gctgcgaagg ttgcatagcc cacagcgatg acaaggccgc cgttgaaaac 2895121 cttcaaaatc aagaatgtcg cactcaatag aaagatgatg cggacaatct gttcaacgac 2895181 ttgggaaaca gctgtcggac ccatcatttg gtgcccttga aagaatccgc ggacaaggct 2895241 cataatcggt acgaccaaaa gcgctaagct gaccatgcgg atgacataaa cgacatgatc 2895301 aattgtcagg ccgttattat ccttgcctcc cagcgatatt tccgcaaaca tcggagccga 2895361 tagatacaga atgaaaaagg ctatcattcc tgtgactagc ataaccgaca tgcccgcctt 2895421 gagcattttc ctgcttgtct cataatcccc ttttgaatta tatttggaaa caaatttaga 2895481 aacagcggcc ggaaagccca tcgtagcaat attcaaaaat aaagtgtatt ggttgtatcc 2895541 gtattgaaat aatgcaccgc ctgtcgcccc gaccataatg ctgaagggaa ttaaatagac 2895601 catccccaga atccgcgata tatatgtacc gagcgttaat acaaacgtgc ctcttaacag 2895661 tttgcttgac atgtttcttc atcaccattt tctacgaaga ttcaactttt ctattttacc 2895721 acaactgggc atttagacgg taataaatac aaaagcaatc ctgtgaacat tcatgtccgc 2895781 ggcaaaagac gtttaaggag cggctttctt tcgctataat agtactgcgg acgggtgtcc 2895841 gcacacgaaa tgaaaagaaa gttgatgata aagatgaaac aatatgacgt aatcgtaatc 2895901 ggcggaggcc cttcaggctt gatggctgcg attgcagcag gagaacaggg cgctggcgtg 2895961 ttgctgatag ataaaggaaa taaattagga cggaaactcg cgatttccgg gggcggccgc 2896021 tgcaatgtga cgaaccgcct tcctgtggaa gaaattatca agcacatccc cggcaacggg 2896081 cgttttttat acagcgcgtt ttctgaattt aataatgagg acattatcaa gttttttgaa 2896141 aacctcggca ttcaattgaa ggaagaggat cacggccgga tgtttcctgt gaccgacaaa 2896201 gcccaaagtg tcgttgacgc gctgttaaac aggctaaagc agctccgcgt aacaatcaga 2896261 acgaacgaga aaattaaatc tgttttatat gaagatggac aggcagcagg gattgtgacg 2896321 aataatggcg aaatgatcca tagccaggca gtcattattg ctgtcggcgg taaaagcgtg 2896381 cctcataccg gaagcacggg agacggctat gaatgggctg aagccgcggg ccataccata 2896441 acagagctgt ttccgacaga ggttcccgtc acttctggcg aaccgttcat taagcaaaaa 2896501 acacttcagg gcttatcact aagagatgta gccgtcagtg tgttaaataa aaaaggcaaa 2896561 ccgattatca cacataaaat ggacatgctg tttacccatt tcggcctctc aggacctgcc 2896621 attctcagat gcagccaatt tgtcgtaaaa gagctgaaaa aacagcctca agtgccgatc 2896681 agaatcgact tgtatccgga tatcaatgaa gaaacgcttt tccaaaagat gtataaagaa 2896741 ctgaaggaag caccgaaaaa aaccattaaa aacgtgctga agccttggat gcaggagcgc 2896801 tatctcctat tcctgctcga aaaaaacggc atctctccga acgtatcgtt ttctgagctg 2896861 ccgaaggatc ctttcagaca atttgtaagg gactgcaagc agtttactgt cctcgcaaat 2896921 ggcacactgt cgcttgataa ggcatttgtc acgggaggcg gggtatctgt aaaagaaatt 2896981 gacccgaaaa agatggcttc taaaaaaatg gaggggcttt atttttgcgg tgaaattctg 2897041 gatatccacg gctacacagg cggatacaat attacctccg cccttgtcac aggcaggctt 2897101 gcagggctaa atgccgggca atacgcccgt tcttaatcat tactctttaa atctcttgcc 2897161 gccaaactca catttgaaca ttccccgcat tcatgttagg gtgagacttg ttttgtttca 2897221 cctgattgcg gggtaatttt aagagaggaa tgagctgcca tcgtacgacc atactaagcc 2897281 tgcgagcaag atataggcgt acacaaaaaa ttagagggtg agaaatgttg aaacatatat 2897341 ctagtgtatt ttggattgtg attgcaatca cagctgcagc tgtattatgg ggtgttattt 2897401 ctcctgacag cctgcaaaat gtgtctcaat cggcacaagc atttattacc gattcatttg 2897461 gttggtatta tcttttagtt gtctctttgt ttgtcgggtt ttgtctcttt ttgattttca 2897521 gcccgatcgg aaaaatcaaa ctcggaaagc ctgatgaaaa accggaattc gggttattat 2897581 catggtttgc catgctgttc agcgcaggca tgggaatcgg cttagtattc tacggtgcgg 2897641 ctgaaccgat cagccattac gcaattagct ctccatcagg tgaaacagaa accccccaag 2897701 ccttcagaga tgcactccgc tatacgtttt tccactgggg tttgcacgct tgggccattt 2897761 atgccattgt ggcattatgc attgcctatt tccaattccg caaaggcgca cccgggttaa 2897821 tcagcagcac actgtcaccg attctcgggg ataaagtaaa cggaccgatc ggaaaggcca 2897881 ttgactgtat tgcagttttc gccactgttg tcggggtgtc aacaagtctt ggtcttggcg 2897941 caacccaaat taacggcggt ttgaattacc tgttcggcat tccgaatgcg tttatcgtcc 2898001 aattggtttt aatcattatt gtgacagtgc tctttttact ttctgcgtgg agcggactcg 2898061 gaaaaggaat taagtattta agcaacacaa acatggtatt ggccggattg ttaatgttgt 2898121 ttatgctcgt tgtcgggcct acagtgctga taatgaactc atttacagat tctatcggac 2898181 aatacattca aaatatcgtt caaatgagct tcagactgac accgaacgat cctgaaaaac 2898241 gcgaatggat taacagctgg acgattttct attgggcatg gtggatttcc tggtctccat 2898301 ttgtcggcat tttcatcgcc cgtgtatcca gaggccggac gatccgcgaa tttttaatcg 2898361 gcgtcttggt gacaccttgt attttgacat ttctatggtt ctccattttc ggcgtatcag 2898421 ccatggatct ccagcaaaaa ggcgcgttca atgtagcaaa gctgtccact gaaacgatgc 2898481 tgttcggaac acttgatcac tatccgctga caatggtgac atcgatcctt gcattgattc 2898541 tgatcgcagt attctttatc acgtcagctg attcagctac attcgtgctg ggcatgcaga 2898601 cgtcgtacgg ttctttaaat ccggcgaatt ctgtgaaact cagctggggt atcattcagt 2898661 ccgccatggc ggctgtgctc ctatattccg gagggcttgc cgctttgcag aacacagcga 2898721 ttctggcagc gctgccgttt tctatcgtta tcctgctgat gattgcctct ctctatcaat 2898781 cgctctcaaa agaaagaaga gagatcaaaa aagcggagaa actcgataaa ccaagaagtc 2898841 caagagtgaa aaaagcatat taacaaaaaa gatctttccg cgcctgcgga aagatctttt 2898901 tatttgcgat ataaaataag ggcggaaaaa cagtaaagct gctcgccgtc tgggtcgcac 2898961 gccgccgaaa ccgtatattt gatatctatc agctgctcct ccgatatccc ttttaaaaat 2899021 gaattgattt ccgtttgtaa gtctttttca tgctcttcat caaataccgc taccttcagc 2899081 attttatccg ctctcctttc tctatcaatc tattccgttt ggaacagcgt tatgatagag 2899141 aaatgatgat tatctcgttt ccggataaaa agctttccgt atatgggatt tcctctgtgg 2899201 ctcgccgccg tgctgctcca ctttcagcag cacggcataa acaatgcgca tatggcagta 2899261 gctgataagg ctgacgctga aaaaagggac aatgcccggc aggtacgcaa gcaagaaaaa 2899321 gagagcaaca gtcagcgcaa gcatagtaag cgtatattgc aaatacgcca cactgagcaa 2899381 gagcgaaaat ttcacataca gacgtttttt ccagtcaaaa tggacaagca gcggaaacac 2899441 ataaaaaagc atggatacga acaaaaagcc aaatatcata atggcgaagc gcaggatgtg 2899501 cagaaggaaa tgacttggat aaattaaggc caaatcaata taaatgatca ctccgatgag 2899561 cgccagtaca gcgccgagca gatttgaacg aaaaaattca cccttgtatt cctgccaaaa 2899621 cgttttgagc accggaacgt tgtcctgccc ctggatccac ttccgcatga cagcgaataa 2899681 agccgcggtc gcgggcatga tgccaaacac gccgagaccg agcaacgtaa aaaacagcca 2899741 cagcaagttt gtatacgcaa atctcataat ccattcgcaa aaacgcagca tccgtcccag 2899801 tgagccatca tgttccatgg cgccccctcc ttttttgcat tatacattct gcatctgaaa 2899861 aagctctttc atgccgatcg gcttcttttc ggcaaccgag cgccacattc cctcaccaac 2899921 cgcgatggag taggctccag cttcagcccc ggctaaaata tcatagcggc gcagcgggtc 2899981 tttccctaaa aaaagatcct caagcaaaag cggatcacct ccgccatgcc ccccttcatt 2900041 tttgaccact tgtatcgtct gctttgattc aaaaagcgga tagtattcga ttgtctgctc 2900101 aggaaaagca aacggaattc tggaaggttc gtgaaattca tttgattcaa tacgtccttt 2900161 tgtgccgttg atcgtcagcc ggtagccttc atacggggcc gaaaaaataa tcgagtagct 2900221 taacagtgcg ccgccatcat atttgactgc cgccacgtac gtatcctcga tgtcaatttc 2900281 ctcgtcaaaa atacacgcgt caggcctgta tgcagtatat aagctggact ggtctcctgc 2900341 ttcaagatga tcatccttta tagaagcttt agaggaacgg ggatgccacc ttgaatagta 2900401 gtggcatttt tctttaacac ggcacgtccc gcaaaaacgc ccgtcttctt ccggcaaggg 2900461 gttccactca ctgtccggcc catagtaatt caaggcgcca taagcaaata cctcttccgg 2900521 attttgcccg agccaccaat tgacgagatc gaagtgatgt gttgatttat ggacagaaag 2900581 accgccggaa aactgtctcg acctgttcca gcgtttaaaa tagctggcgc catgatacgt 2900641 atcaatatac caatttaaat caacagaagt gaccctgcct atttttccgt ccagaatcat 2900701 ttcttttatt ttccgatgaa acgggctgta gcgatagtta aacgcgacgg tgacttttcc 2900761 ttcgcttttg gcctccgctt caagcacccg attcgcatcc tgcactgttg tcaccattgg 2900821 tttttcagta atcacatctg tattccactg aaggcttttt acaatatatg cgacatgcgt 2900881 atcgtccctg cctgccacaa tgacgatatc aggctttgag acgcgcatca tctcgtcaaa 2900941 agcatcttcg ctaaactcag gcacgtgggc cagctcggga aatttcttct tgcaaacggc 2901001 aaaacgtttc ggatcggcat ccagcaatcc cgtaatctca taatgagttg aaaaccgctc 2901061 catcagtggt ttgataaaca tactgaatgc tctgctgctc aatccgcaaa agacgatgtt 2901121 cttcaatatc ctcacctcta tcgggcttca gttagttgag aaatcagctg cagcgcttcc 2901181 tctgtttttt cagcatacac agggataaac gccgccatat cgcgattcaa ttgaaaagaa 2901241 tagccgttca gctgtttttt ccctttttcg atctgaacgg catagatcgt tttttctcct 2901301 gtttttttat taacagttgt ataaggagat gttttttcag gaggcaatcc gtttaacggc 2901361 tgaaaatttt ccggatcatc gtaagcttga aacatgtctt caggcacgat gaaaacatct 2901421 ccctcatggg cggtaatttc agtcagcagt ttttcctgaa aagctggaaa gatatcgacc 2901481 ttcccggcat tctgctcggc ggcctttttt attttttcct gtacgccagc ctgcatatca 2901541 gaaaagagaa tgacatgcat tccgtccggc ctgcttgagc atgatgccaa aaagagcact 2901601 gagacgatca cacacaaagc cgtacgtatc ctttttgtca tttccccgct gacctaaaaa 2901661 gaggctccag ctctgtcata gctaaaataa acgcgccggc tccgtgcaga tcgtttgtgc 2901721 ttctttcgcg gctgacataa tagtcataga aaccggctga cgttccgaca catatgtctt 2901781 tgacgagaaa cgctccgtct tctgatgttt cggttttatg ctgaatcaag ccttgatacg 2901841 cttttagcag tgttgtttcg taagctctgt ctagatagcc tttattgatt ccttttgcga 2901901 ttgcgtacat gtacagacag gatcctgagc tttccagcca gttatcagac ctgtctccct 2901961 tatcaacgat ctggtaccat aaccccgtct ctttgtcttg atagcgacag atgcttttaa 2902021 tcatgtcctg cagcgtgttt ttccacacat gacggttcgg atgcttcttc ggcagctctt 2902081 caatcatgtc agcaagagac atgacgtacc agccgatgga acgtgcccaa aattccggtg 2902141 aacagcctgt ctcttcattg gcccaaggca tttttttcgc ttcatcccag gcgtgataaa 2902201 aaagtccggt ttttgcatcc ttcgtatgct ttctcatcaa tgactcctga agcacaacct 2902261 gatcaaacag ctccgtctcc tgcttcagat tggcatattt cagtgcaaac ggccccccca 2902321 tgtataagcc gtcaagccac atttggtaag gataaccgtc tttgtgccaa aaaccgccct 2902381 cagacgtccg gttcagtgtt ccatataagc tgcgcagcct ttttgccgct ttgacatacc 2902441 gttcatcctt cgtctgctcg tataatggaa aaagaatgag acctgcttga atggcgtcca 2902501 gttcatctct tctaaataat agattgccat tatcatcgat taagagatct gcataagcct 2902561 tcgcatactc aaaataccgc ttttccccgg ttgcttccca cagccgcaat acaccgcata 2902621 agaaaacacc ctgatggtag tgccagcggt ttgcaggtgg cagctcctcg actgtgtacg 2902681 tgttcataat ggtgtttgcc aatgcctccg cgtacgtaag aggcgatttt acagcgattg 2902741 attgatccat tgatcccatc cctttcctaa taaattcctt cctcgccaaa tttcttcgcc 2902801 aaacgattcg ctagcatgac caaaatcagc ccgaccgccg ctttaaatac gccgactgct 2902861 gtactgtagc tgaattggcc ctgtttcagc cctgcagtat aaacatacgt atcaaaaatt 2902921 tccgccactt ccctgttagt cgcatttaac agcaaataca catgctcgaa gccaagctcc 2902981 agcgtgtctc cgattttcaa aatcagcaaa acgacgataa cgcttttaat ggcgggcagc 2903041 gtaatatgcc acatttgccg cagccgtccc gctccgtcca ttttcgccgc ttcatacagc 2903101 tgggggtcaa ccgctgtaat ggccgccaga taaatgatcg tcgaccagcc cgcttccctc 2903161 cagataacct gcagaatata caggggccgg aaccattctt cgttcagcag aaaattgatt 2903221 ttttcaccgc caaaaaacac aatcagttca ttaatcaagc ctccgtctac cgttaaaagc 2903281 acaaacgaaa gcgatacaac aatgacccaa gacataaaat gcgggatata aatcagcgtc 2903341 tgaacaaatt ttttaaagag agcaatccgc acttcgttca atagaagcgc cagcagtatc 2903401 ggcaccggga aaaatatggc caggttcaaa gcaaataaca cgagcgtgtt ttttaacaag 2903461 agaaaaaatg taggctcagt aaacagcctg ataaaatgct tcagccccac ccactcactg 2903521 cccaaaatgc cgaggaacgg ctgataatcc tgaaacgcaa tcacaattcc ccacatcggg 2903581 acatacttaa aaagcaaaaa ataaatacac cccggcaaaa tcatcaagta caaatatttt 2903641 tgttgaatca gcttgattag taagcgcttt cttttttctt ttttaaaaat gactgcatca 2903701 acagccggcg cttgcgcttc tgctgttttc attttttcct agcctccttt cacggattct 2903761 tgcattcact gtagcgcagc aggcaaaagt ccgtctacaa tcatatgatc acatcctgtt 2903821 ttatcccttt ataatcaagg gttcagccgg tccacctgaa aaaaagacac cgatattaga 2903881 aaatgattat tgacaatatc tatcaatctt tggattaatt gtattaaggt gaagtggatg 2903941 ttatgaaatg gggggtttta tgaaaagaag ccaatacaag ttttactaca aactgatcac 2904001 gtttttctgc ctgctcagca ccattccggt tattttggtc ggattatttt cgtacgagca 2904061 ctctcagaaa acggctattt ccaacgtttc ggaggaaaaa ttcgacacac tccagcagac 2904121 ccagcaaagc atcgagcata tattgaaaac cgtcgatcac tctttaaccc actatgtgag 2904181 ttcgccgcct ctccttcgca cattgtccga gcctttgcac tcagaccaat ttcaaatcta 2904241 taaccaagtg aaccaagagc tcaattatct gcaaagcttt gataccgatc tgtccaacat 2904301 gacgttagtc agttatacga aaaaatggta catgaacaat tccggtttgt accgtttgaa 2904361 tacagacact cttcatgaag cagcctcagc gtacacgaaa caaaaagcga gccgctccta 2904421 ttggacgctt gaggaaaaca atcatttgat ttcaaccaaa gaaggcacag cagaaaactg 2904481 ccgctacaat atcaatttaa ttaagcagct tcctttgaac agcacaaata caaagggatt 2904541 ggccgccgca agcatcccga gctgttcgct tgtcaaaaat atgcccggct attcaaacgc 2904601 caacaacctg tttatcatcg atgaaaaagg cctcatcatc cttcataaca atatgtctga 2904661 cgttggtgaa tctcttcata acgacggctt tgtccaaaaa gtgctggcgc aaacggccaa 2904721 tagcggacag tttgaaacag tgattgaccg gattcattat aaagtcacct atcaaaaatc 2904781 tgactataat gcatggactt atttttctct cgtttccctg cctgagttaa aaaaagaagc 2904841 caaatcaatc ggctggatca cttttgcagt atgcctcatt ttgttaacgc tttcattgct 2904901 gttctcttgg cttggctccc gccattttta caagccgatc agggtgcttt acgaatcatt 2904961 cgcaagacat ggagccatac aagagaaaca acagcctcct caaaatgaat ttgagttaat 2905021 tgaacagagc tttaagcagc tgaaggacag aaatgacgac cttgaagaaa cgatgaagca 2905081 gcaggccact catctgcagc aatattttat ggtcaggctt atgcttggaa aactgacgga 2905141 tgaggaggtt gataaccgtt ttgaaagcct cggcttaaag caaaattggc ggcaccttgc 2905201 cctgcttgtg ctccaaattg acacactgaa tcatacgcct tatgagaaaa aagatatgga 2905261 tctgcttttg tttgccgtca acagcctgat tgagcgcaac atcccgacgg acaaacatct 2905321 tgcccccgcc gtagttgaca aacagcaggc gacgattttg atcaatcaaa gcgggacaaa 2905381 ggaagaattc atggctgagc tgaatgagac tgcaaggatg attcaggaaa aagcggaagc 2905441 tgagctgcag ctgtctgtca gcatcggcat cagccagccg tttgatgtgc tgacaaaagc 2905501 gaaaacagcc tatgcggaag gctcagaagc gttgaaatat cggctgaaag cggaaaacaa 2905561 gtcgatcatc ttttacgaag accttgacca gaaaaaaacc ttcaaaaccc attttccaaa 2905621 gcagcttcag catgagctgt tcgatgctgt caaagcagga gacaaggaga aagcggataa 2905681 atgcctgcac gcgattttac aagccatttt cacccagaac accaacccgt atcaatttca 2905741 aatcgccatc gcccgttttt tgaaccatgt gattgagctg atgcatgtgc ttgggatcga 2905801 attgtttgag cttgaagaaa acaaaatgct gtatgaccaa atttttgagc tgaaaacgtt 2905861 cgaggatacc gaaaactggc taaagaatga gtttattgat ccgatgacag acaaagtgaa 2905921 cgcccgcgcg gatgcccagt acaaaaatat ttccgacaac atcattcata tcatccatca 2905981 tgagtttgaa tccgaattga cactggacga aatcgcacgc aggctgcatt acaacccaaa 2906041 ttatttaagc agtattttca aaaaagaaat gggaatttca ttcagcgagt atgtctcaag 2906101 ctaccgacac catatggcga aaagctggct tgccgaaacc gacatggcgg tcaaggacat 2906161 tgccgaaaag ctgaaatata aaaactccca aaacttcatc agatcattta agaagctgga 2906221 agggattaca ccgggaaact accgccagca aaaaagaagc atgtaaaaaa cccaaaaccg 2906281 cttgcgcgtt ttgggttttt ccaatgttat tttgcttgtt taaacgcttc ttcgtattcc 2906341 tgaataattt gttttcctcc gcttgactcc catttttcca cttctttatc gaactggctt 2906401 tctgtgatgt ctccaatcat atatttgtag gtcgcgtcat caatgatttt cttcagttcg 2906461 tcaccccgtt ccgactccga tgcggaatac aggctttcag ccgggtttga gacgataatc 2906521 ttttcattgt cctcggtcag ctcctcgtac gccgtccgaa gcggatctcc agtgtttttt 2906581 aagtaggctt tatcaatggc aattaaagcg gacagcggct gaatatcagt ctgccagtct 2906641 tttacctggc tttctttgcg tgtaaacgtt ttgtcctcac ctttgttgta atgaacgccg 2906701 tcaatgccat aagtcatcag gctatagaca tcttcttcgg caattcggtc aaaaaacgcc 2906761 aagatccgtt taagctcagc ttccgttttc acactcgttt tcgggaaagc aaacacgccg 2906821 ttatggcctc ctgatgccca tacccgctct ttcccatctg ggccttttat gcggttgatg 2906881 atctcgagct tcatcgattt atcagaggca tggtcgcgca gattgaccgc atctaccata 2906941 ttgccaatat aaattccggc ttttccttga gaaaacagct cttgctgctg ggttttgctt 2907001 gtgacgggaa aatccttatt catatacccg ttatcacgca gctttttcat atagttcatc 2907061 gtgtctttgt attcctgtgt catgaaatca ggcgtgaatt tgccgcccga ttccttccaa 2907121 tctgtcggca tgccttcata cgagccaatc gttttaaacg cgccgtaaat caagtcatta 2907181 cggtctgcca gcccgaatgt atcatctttc ccatccttgt ccgggtcgtc ctccgtaaat 2907241 gctttggcca cttcataaag ctcatccaac gttttcgggg ttttcaaatt taaattgtcc 2907301 agccagtcct tccgaatgac gatcccctgt ctggaaagcg ggcgctctct gtatatcccg 2907361 tagagcttgc cgtcaattgt cacattttta ttaatgagtt tgttcatttt gtttaagttg 2907421 ggataatcct tgatataatc gccgatttcc caaaacattc ctgaccgaaa ggcattcatg 2907481 actgacgaat ttttaatatc ctggatggtc acgatttgcg gaagattgcc ggctgcaagc 2907541 gctgcattca gcctgtcttc tttcaccgcg tctggaaccc aggtgatgtc gagttctgta 2907601 tttgtcagct tttcaatttc tttaatcgcc ctgtctttcg gcggctgctg gtgatacaaa 2907661 atcgccatcc aagacagctt tacctttgaa tctgggccag ctttgccttc agccgaagac 2907721 tgatcagttc ctttacagcc cgccagcact ccgccgagtg ccagtacaag cacaatcaaa 2907781 agcaccctcc atttgtttcc catcgtaccc ctccgtttca tatttcttta tcctttgaca 2907841 gatcccagca aagctccttt tgcaaaatgc ttttgtataa acggatagac aagcagaaca 2907901 gggatggtcg ccaccactat gaccgccatt ttaatggttt gctcaggcgg cgggctgccc 2907961 gaccccattt cagacatatc cccctgcata ccgcttgata caatgacgat ttggcgcaga 2908021 agcacctgaa ttggccattt tgctgaatca tttaagtaca agatcgctgt catatacgtg 2908081 ttccaatacg tgaccgcata aaatagtgaa atcgttgcga tcgcaggaag agacagcggc 2908141 agcacaattt taaagaatat gcccagatca ttgcacccgt caattttcgc ggactcttcc 2908201 aggcttgacg ggatattttg aaagaagttt ttcagaatga tcaggttaaa ggcattaatg 2908261 gctgtcggca aaataagcgc ccagtaagaa tcgagcaatc caagcgattt gaccacaagg 2908321 aaagtcggaa tcatgccgcc gctaaacagc atcgtaaata cgacgagaaa catgagcggc 2908381 tgccggccga ttaaatcacg gcgggataac ccgtaagcca tcagtgacga aagaaacatg 2908441 ctgaccgcag tgcctatcac tgtcacaaac acagaaacaa gcaaactctt ataaataata 2908501 tctgttgaaa aaatgtagcg ataagcatct agcgaaaaag tggtcggtat taaaataaat 2908561 tttttcgaca cgacttcttc tactgtggca aaggatgctg cgataacatg aatgaacgga 2908621 agtacgcata ttaaagcgaa catcagcaag aaaccataaa tcaacatatc aaacagacgg 2908681 tttttcagtg aatgtgcgat agctcccacc tccctttgta agcgttatca tatttttgga 2908741 aaccgagctc agcatgtgac gatatcgtgt ctaaaatgta gcaaatctgt gattgccatg 2908801 tctataatca tttgaacagt gtccccggcc gggcgggggc tgccgcgaat tgagaccgat 2908861 aacaaaagaa aaagagcata atcttagaaa atgattatgc tccgttctcc tcctcgttca 2908921 gaagttcagc cgtattgatt tgtggcgaaa acccaagttc attcacggca gattcaatgg 2908981 accatggccg gcccggatta tcagagacgg cgtaataagt gccataccgg atgttggtct 2909041 caatggcggc tttgaaaatc gacagcagat cggggtgaga aagcagtgtc tttttcgtcc 2909101 gttctttttc atgcagcgta tccatttcat ctgtcacgac tgttccgatt cgaaggttga 2909161 ttactgatag cttattttcc aaataaaaca aatggccgat ctgttcagag gtcagcttta 2909221 atacaccgta caagtttttt gacagcggat aatcgcttgt tgtgatttcc cgtcctaaga 2909281 gcgagcgccc gtctttttca tatacatctg tgacatgatt gctgctggcg aacacgagct 2909341 tttgaatgcc gagctccgct gccgcacggc acagataata gcttgcccta tagaaaacat 2909401 ccgtcatttt ttcaaactca gcgatgtcca taatatcgta tttgattttc acagcgagta 2909461 aattcaagat ggcatcggta tcttttggaa tcttcttcaa cagctcctca taatttgccg 2909521 cgtcagcctg aatggaagag gctttgccat cgaaatgatc tttatcaagc acagtcactt 2909581 catagtctga aataagccct tcagcaagca gtctcccaat cacaccattt ccgccggcga 2909641 tcagcacttt tttcacgatg ttcactcccc ttttttatag attgcccatt ttcggcgggg 2909701 ctgacacttt tttggcactc acattcttag gcttattcaa aagtcaccgg cagctcctca 2909761 agcgcccgaa atccaaaaag cggccgatac cgccattcaa aatccgcaag attaaggctg 2909821 ggcattcgct gcagaagagt gttaatcgca atttgcgctt ctaatcgtgc cagcgaggac 2909881 cctaagcaaa catgatggcc atgcccgaat gaaagatgcg gattaggact tctcgtaata 2909941 tcgaagacat cggggttcgt gaatatgcta gggtctcgat tagccgctcc taacaaaaga 2910001 tagacttgtt ctccttgacg gatcgtcacc ccgcagatgt caatatcctc tgacgcaact 2910061 ctggctgtca tttgcgtggg gctttcatag cgtaaacatt cctcgactgc ggtaccaata 2910121 agatctggat tttctctcag tttcaaaagc tgttctggat gctgcagcag acaaaggact 2910181 gaattgctga tgagattgac cgttgtctca tgtccggcga tcgccagcaa tatgcacgta 2910241 gatgccgcct cctcttccgt cagcttatcc ttttctctcc ccttcaagag catgctgatc 2910301 atatcctgtt gagggtggcg ttttctcttt tgaatcagct ctttgaaata tgccatagcc 2910361 tgcacagcca taatattgcc ctctgttaat gcctttcttg agcgggtaaa atcaatcgtt 2910421 tgaatgagac tcgcagccca ctcctttaat tgctccctat cttcctccgg tacacctata 2910481 atgttagcta tgacaaaact tgctaaagga aaagcaaagt ccgaaatgac ctccatcttt 2910541 tttttacctt gcacttgatc aagcaaatga tggacagttt caatgatata cggctgataa 2910601 ctctctgtcg ttctcggcgt aaacgctccg ctggcaagcg tccgcaatcg tctatgatca 2910661 ggctggttct gaaacagcat catttgattt tgcacatgtg aaaggtcctg atatttggtt 2910721 gagctctcag gcagcggggt gcggactttg aatctcgcat ctttcaaaat agcagccgtt 2910781 tcttcatatc ctgtgacata ccagcccggg tattttaaga aactcccttt atagatagga 2910841 tgaacagctc gcaatgtgtc gtaaaaagaa tatgggtttt tcaaaaactc agaagatgca 2910901 gttgacgatg caattgtcac gtgattttct cctttctgtt caaaaataaa aacaatcgac 2910961 atcataccga ttgcttttat tgattctttc agcttttcgc acttaaacta gccttcattt 2911021 cttcgactga ttcaacttca aagcctaaat cactcagcat tttatgatcc tccgtctcct 2911081 cttgcccggc agttgttaag tagtctccga caaaaatgga gtttgcggcg taaagcccta 2911141 atggctgcaa tgtgcggaga ttgacctctc ttcctccgga aatgcgaatt tcttttgatg 2911201 gattgataaa acggaacagc gccagcactt ttaaacaata cagcgggttt aattcgttga 2911261 cgccttctaa cggcgtgcca tcaattgcat gcaaaaaatt cacaggaatg gaatccgcgt 2911321 caagagcctt caagcttttg gcgatgtcaa tgacatcctg tttcgtctcc ttcatcccga 2911381 taatggcgcc tgaacacgga gacagccccg attcttttgc gatttcaacc gtattgactc 2911441 tgtcatcgta tgtatgtgag gttgtgatgt ttgaatggtt tctctgtgac gtattcaaat 2911501 tatgattata gcggtctact cctgcatctt tgagccgctt cgcctgctct ggcttcaaca 2911561 gtccaagaca tgcacaaatc ttcagtccat acgtctcttt aatttcctga accgcatcta 2911621 cgacctgatc cacttctctg ttagacggac ctctgccgct tgccacgata caatatgtgc 2911681 cgatattcag atcgtgcgcc cgcttcgcgc cttcaagcag cgtttcctta ttcaccatcc 2911741 ggtaagactc aatcggcgct ttcgaaatcg cagactgtga acaatagccg cagttttccg 2911801 ggcagagccc ggatttcgca ttcataatca tattgagctt tacttttttt ccgtaaaagt 2911861 gttttctgat gtgaaaagcc ccgtgcatta atagcaaaat atcttcatca ggacaatgta 2911921 atattgaaag cgcctcttcg tcagtcactt ctgctccagc cagcacccgg tctgcgagtt 2911981 ccatccattg attcattctc atacccccac ttgattcatc agtaatgata gattgatatg 2912041 gtcttttacc atatgtagaa ccgtttcttt cgtcacgttg gcaagctttg gcgtaacccc 2912101 taaaatcggc acaccgcata agcgctcaat catctcagga ttggtttttt catcttcatc 2912161 aggagagtca ctgattccat tgatgataat tccggcgatt ggaagcccca tgctttctgc 2912221 atatttgaca gttaaaaagg tatgattaat ggttccaagg cgaggacgcg ccacaataat 2912281 catgggaagc tgcaacgctt ttatgacatg actgaccaaa tagtcctctc ccaatggcac 2912341 agaaataccg cctgcacctt ctacgatgaa gcattcatgt ttttctctaa tccgccccca 2912401 atggcttaaa acctcttcca tggtgacagt ctttccctca agtttccctg caacgtatgg 2912461 tgcaagcggc gccttgaagg caaaaggcgt aatgtcttca tgagaaagac tggtctgcga 2912521 catatctttc agcaaacttg tatcactatc tggatgatgg cgcgatatcc cgcttaaaaa 2912581 tggtttatac accccgacat gtctattatt gtctttcaat aaggcagcaa gaccgctgga 2912641 tataaccgtt ttccctactt ctgtatcagt tcccgtcaca aaaaaacccc tcaaatgatg 2912701 tgcagctcct ttccgattga atgaaatgtt tgcagcaaat gatcaatatc acccatactg 2912761 tggtcagacg tgattgtaat tcgaatccgg ctttcacccg gcgcaacggt tggcggccga 2912821 atggcaggag cataaattcc cttgccctgc agtttttcag caaataggac cgttttatgg 2912881 gcatcgccaa tgactacagg aataatcggt gtgtgatctc ctttcaccac ataacccata 2912941 ttcttcagac tggttctgat catgctgata taagaaaata aaagctgtcg tttttccctg 2913001 ctggcttcaa tgatgttgaa agcctcgtga gcagccgcac agctggctgg cggaatagcg 2913061 gtttgaaaga taaatgttct ggcatggttc agcaaaaagt cgatgaagac cgctgatcct 2913121 gccgcaaaac ctccttccgc gccaacagct ttgcttaagg tgccgataac aatgtcggga 2913181 caaacaccaa agtattcact cgttccttgt cccgaatcgc ccaaaactcc tgttgcgtgg 2913241 gcatcatcaa cgaccacgaa ggcatgatag cgtttcgcaa gtgagatgat ctgatcaaga 2913301 ggggcgattg tgccatccat gctgaatact ccgtctgtta cgataaaacg gcgctgataa 2913361 cgctgtgttt cattcagctt gttttcaaga tcattcatat caatatgccg ataaacaact 2913421 gtatcagcct tagaaagtcg gcagccgtcg atcatacttg catgattgag ctggtcactt 2913481 aaaatgacat cttccttttc tggcaaggat gaaaggacac cgacattggc caagtaaccg 2913541 ctcgaaaaca gcagggccgc ttctgtcagt ttaaagctgg caatcttctt ttctagcttt 2913601 tcatgccaga ccgaattgcc tgtcgttaaa cgtgaaccgc tgcttcctgt cccaaattgc 2913661 tgcaatgctg tttgggctgc atcgatcaaa cgtctatcgc ttgcgagccc taaataattg 2913721 tttgaggacc agaccgtttg attttcgcca tcaatattcc tctctggaac cggcgctcca 2913781 tccattgacc gcaggttacg atgtacgccg gcttctttca ttctgtctaa ccgctcgttt 2913841 aaccaggaat caatcttcaa ggctcgtaac ctcgtggatc gcttgtttca taatggcaac 2913901 catttccgag agctcttcag ctgtgctggc aagaggagga agaaatgcaa tcacgtcccc 2913961 aagcggtctt gtcagcattc ctaactctct catttttaag gaaactttgt atccaatccg 2914021 ccgatcagcc gggtaaggtt ctttagtttc ctttgatcgt acaagctctg caccgcacat 2914081 aaagccaagc tgccgaatat ccccaacatg aggaagagcg tgcagatctt gaagaagaaa 2914141 atggagcttt ttactttttt ccgctacttg ttccacaatg ttttcagatt caaataatgc 2914201 cagattttca agcgcaaccg cacagccaag ctgattgcct gtataggaat ggccatggaa 2914261 aaaggttttt aggttttcat aatcatcata gaatgcctta tagatgtctt cagtggcaaa 2914321 cgtaacggca attggcaaat agcctcctgt aatgccttta ccggcagcca tcagatcagg 2914381 ctggacattc tcgtgctcgc acgcaaacat ttttcctgta cggccaaagc ctgtagcgac 2914441 ttcatcaacg atcattaaga catcgtatgt tgtacatagc tcgcgcacgc ctgccaaata 2914501 tccttccggc atcacgatca taccggacgc gccttgtacc attgattcaa tggaaagcgc 2914561 ggcaatttcc tcatgatgtt cctcaagcag ctgtgcaagc tctcggaggc actgatcacg 2914621 gcactcatca ggatcaccgc tttcagaacg atacacataa ggaatcgggg ccttgtaact 2914681 ctcgaacatc aacgggccgt atacgtggtg aaaaagctca attgaaccga cactgacggc 2914741 gccaatcgta tcaccgtgat acccgttttt cattgcgatg aatttttgtt tctcgggctt 2914801 cccgatgttc ttccaatact gaaacgccat ttttagggct atttccatcg cctctgcgcc 2914861 gctgtctgaa taaaagaccc gcgtgagctt ttttgggctg atgtcgatta atgtttcggc 2914921 aagctgggtt gctggaacat tggtcatgcc caataacgtg gagtgcgcaa tttttccgag 2914981 ctgttttttt atggcgtcat ctagttcttt tttgcggtgt ccgtggacat taagccaaac 2915041 cgatgaaaaa ccgtcatagt attccttgcc gtttatgtct ttgactttga ttccagtccc 2915101 gctttcgatg attaaggggt tttcatcata atctttcatt tgggtaaatg gcagccagag 2915161 gtgcttttta cttttttcta tcaaatcatg agtcatgatc ttcctcccac tctattaaaa 2915221 taggctgctt ctccaggtca tgtatgtacg tgtttacatc attggatcca tcaataaaaa 2915281 agactcggca gccctcttca gtcccgtatt ctttcattgc tgtaatacgc tgatagccca 2915341 ttttcttacc cgcaacatag cctgttatgt aatccggatc gtccgaccag cataattctg 2915401 caacgactgc cgggtgccgg cttacctttg aagcgagcgc aagggcctct tttattcttg 2915461 aatgagctgg cacgtgactg tgaagcgccc atttttcaaa attagcgtcc ggccaatcca 2915521 ttctggagac ccgcacccct ttttcttttg tttgatccat tcgcttgcct gtatgaatat 2915581 caaacaacac cgcacccctg acatctgacc attcagggat ttgttcatat gctttttcaa 2915641 tcacgtctcg tgaaacgcct tctttttcca ataacaatcg ggcaagcttt tgtccttctt 2915701 ccgggcagct cacttcattc gtatgcacag gcaatggctg aatggttttt atcgattcat 2915761 gtacctcttc aaattgaatt tgcataaaat caggttttcc tcttgaatgg gataaccctt 2915821 tttctaataa agcattgact gtatgcttca tctcatggaa aggaataagc cgttctccgc 2915881 cggatatatg ctttccgccg tcttcatgag atccattcat tgaagccctc attctgacac 2915941 tataaaaagt ttcttcttgc atcatttctc gccctttcac tgataactga agaacgtgta 2916001 gcgcttctca cctaaattgt taaccaatta tattcaaagg ttaacaatta gaatatatta 2916061 ttctctcctg tttctgtcaa tagaagaaag gatcgattta tggcagttgg ttaaaaggaa 2916121 acaaaaagac cgttttcaca caaaacggtc tttttcgatt tctttttaca gtcacagcca 2916181 cttttgcaaa aaccggacag cttcatgcct tataactgct gtttcgaaat gtcccgaagc 2916241 agaacggacc actcggtagc aatcagcagc tccctgtcca gcatagacag ctgtcaattc 2916301 tttttcgatt ttgtccacgc cctcagccgg cgttaaccga tcgtgtacac caacaagact 2916361 aaggtgcggg cgcggcgcga tcaggctttg gatctccgat gcggaaaaat gctttgcaag 2916421 cgatgggacg taataataaa agccgtgcct gtcaagattc tgtgttttga tcagcacgtg 2916481 atgatccacc tggctgcaca aatccacaca caccttaatc cggtcatcga gcgccgctgt 2916541 ccaccacgcc atcaaacctc ccatagacat gccgatggtt ccgatcctgt caggctgaac 2916601 atcagagcgt gactgcatat agtctaacgc acttaaactg tcataaatca tcatccccca 2916661 catcactttt ccggtgagaa gcatttcttt aaatatctcg ctttccgctt ttccccgccg 2916721 atctccaaac ccccaatgat caatcgcaag aacgccgtat ccgagtgaag taagctcatc 2916781 agaaaaagaa ggcgttttca aataatccgc tccctcaatc agctcacttt ttcccctatc 2916841 atactggcct ccatgcgaat gctgaaacaa tacggctggg cacggtcctt ctgttttctt 2916901 cggcttcaca aaataagcgg gcgccttttc atgtccattt aaatcgagca ggagcgtttc 2916961 aacgatattt tcttctcttt cttcaatacg taatgtctca acactgattg gcctccgatc 2917021 aggcaaatca ccaagcaatc gaaacagttg ctttcttctt tcggctctca tcccatcacc 2917081 cttccttatt cgcttacttc acatttacga gacagatctg ggttcccctt tatttttcca 2917141 acataaatca catcatttac taaatattta gtaaatatta tggaatattt cgaaaacaat 2917201 tattgtaacc gcttactttt atatgataat atcaatttat caaaaacaga tgagttaata 2917261 ttttactaaa tagatgagag ggatacccat ggttcgtatt aaagatatcg ccttgaaagc 2917321 taaagtttcc agcgcaactg tgtccagaat tttaaatgaa gatgagtcgc tttctgttgc 2917381 gggcgaaacg agacaaagag tcatcaacat cgctgaagag cttggttatc aaaccgttgc 2917441 caaacgccga aaatcccgcg ggcaaaaaca gcgggctcag ccgctgatcg gtgtgctgag 2917501 ctgtctgtcc cctgatcagg aaaggcagga cccttatttt tcttccattc ggaaagggat 2917561 tgaaaaggaa tgctttgaac aggaaatttt cattacaaat tcgattcatc tcggctcctt 2917621 tcaggaacat atctttcggg aattggatgg tgtcattgtc atcggccgtg ttcatgatga 2917681 agcggttaag catatcagcg ggaggctgga gcatgccgta tttatcaatc attcaccaga 2917741 tccgcaagca tacgattcga ttggcatcga ttttgaatcg gcttcacgcc aggcgattga 2917801 tcaccttttc gacttaggct acaaacggtt aggctacatt ggcggacaag aaaaagagca 2917861 tacgctgaag gacggccaaa gcattcgcag aacgattgaa gataaacgcc tgaccgcttt 2917921 tttggagtca gccgcccccc agcctgagca tgtgctgatc ggagaataca gcatgcgtga 2917981 gggctatcgc ctgatgaaga aagcaatcga tcaaggccat ctgccggaag cattctttat 2918041 tgccagcgat tctatggcga tcggcgcatt aaaagcgctg caggaagccg gactgcaagt 2918101 gccgcgggat accgcaatcg tcagctttaa cggcattgag gaagctgaat ttgccagcac 2918161 gcctttaacg acggtgaagg tatacacaga ggaaatgggc cggacaggcg taaaactgct 2918221 gcttgaccgt ctcaatggcc gaacgcttcc tcaacatgtc accctgccta caacattaat 2918281 cgtaagacaa agctgcggat gtacagcaaa ggaggtgaca taagcaaaga ttcatcacga 2918341 tgataaggag gaaaagatga aacacacttt tgttttattt ctctctctta ttctgcttgt 2918401 tctgcccggg tgttcagcag agaaaagctc agcagatacc gcaaaaaaga cgttaaccat 2918461 ttattctaca atgtcaaccg acagtgaaag agatacgttc agaaaactag cggcagcatt 2918521 cgaaaaggaa cacagtgaca ttcatgtcag ccttcatttc ccaggcaatg actatgaaaa 2918581 tatgatgcgt gtcagaatgg cggccaatga tttgccagat ctattcgata cacatggctg 2918641 ggggaaaatc aggtacggag aatatacagc ggatctccgg gatatgaaat ggactcaaga 2918701 tcttgatccc aatttaaaca gcatcctcaa aaataaaagc ggaaaggtgt atgcctatcc 2918761 aatcaatcag gcaaaagacg gtctggcgta taatcgcaat attttagacc gttacggcat 2918821 tgctccgccg gaaaccatgg atgactttat caaagcactg agaacgatta aagaaaagag 2918881 caagggaagc attgttccct tctggtttgc cggatatgac aaaagctcat tcgcccaata 2918941 ttacgaccaa ttcgctacac ctcttctcat cacagaccct gcccataatg aaaaaaaaca 2919001 gctcatcaac ggcacttttc aatggagtaa attcacttat ttatcagaaa tcctcaaaca 2919061 aatgcagaaa gaaaaattga tcaatatcga cgccgtcacg gcaaaaaaat cacagctcat 2919121 tgaattaatg gcccaaaaca aaatcgcctt tacaatgcaa ggcggcacac tcggccaaga 2919181 cgttgcccag atcaacccga acgtcaaggt cggcattatc ccgacacctg ccatccatcc 2919241 cggtgatgac ccgatatgga tcggcggtga acgctacacc cttgcagcat ggaaagattc 2919301 gcctcaatta aaagaggcaa aagattttat cgcatttatg gcccgcccgg ccaatgccaa 2919361 acaaatggct gaagccacat cgcttccttc agggctgacc aatgtgaaag ctgatatttt 2919421 ctacgcaaac gattatgagt attatcaaga tgtcaaagtc gagccttact tcgaccggtt 2919481 atacttgcca aacggaatgt gggatgtcct gggcacggtt gggcaggagc tcgcggctga 2919541 cattttggcg cctcaagaca tttcgcagaa gctgggaaga gaatataaac gactccggga 2919601 gcaatccgaa acacagggag ctgaaaacaa tgagtgagat cgcaagggac gttcatgtga 2919661 aacaggttaa gccaaaaaag cagtcctcac tttggtggat gtacattcct gctttgctct 2919721 ccgttctggt ctttatgatt tacccgtttg tgaaaggcac attgattacc tttacaaact 2919781 ggaacggatt ttcacaagtc taccaatggg ttggattcgc gcaatatgaa aggctgtttt 2919841 ctgatcctga tacttggcat atcttaaaaa acacgctgca ttacgggctt ggcagcacct 2919901 tttttcaaaa tgtggtcggg cttctgtacg ctctcctctt aaatcaaagc attaaaacga 2919961 aagcggtaac aagaacaatt gtgtatttgc cggtgatgat cagcccgctc attatgggct 2920021 acatttggta ctttttcttc tcctatgacg gaggcgcgct caacgatttg ctcggggtct 2920081 tcggcatcag ccctattaat gcgctcgcca gtccctcgct caatccatgg atcattgtca 2920141 tgattaacac ctatcaatat gtcgggatcg ctatggttgt ctacttagcc ggtctgcaaa 2920201 gcattccgaa agactactat gaagcggcgc aaatggatgg cgcgaaacaa ggccagcagt 2920261 tttttaccat cacgctgccg ctgttaatgc cctccattac cattaatata gtcatcaaca 2920321 ttatcggagg cttaaagctg tttgacgtca tcattgcact caccgcaggc ggccccggaa 2920381 atgcgtcaca atccatgtcc acgtttatgt atgatttgta tttcaaacgg caggatgccg 2920441 gctatgccgc aacgcaaggc atatttatgg catttgtcat tttgatcatc agcttttgcg 2920501 cgcttgcgta ctttaaaaga aaggagacgg aaatgtcatg agagccgccc gtacaaaaag 2920561 catgcggatc attacgcttc ttgcagccat tgtggcctgt gcgcatttta ttccttttta 2920621 tatcctgctg accacttcat tgaaagcaaa aggagactac agttcgaaat ggatatttcc 2920681 agccgacatc tcctttcata atttttcaga ggcgtgggag cgcgcttcgc taggaaactc 2920741 ttttataaac accatgatca tcacaggttt ttctgccttg ttattaatta tattcggctc 2920801 acttgccgcc tacccgcttg cccggcggga aacgaaactg aataaagccg tttttgcctt 2920861 gctgatttcc attatgatca tccctccgtt aacgtccatg gttcctttgt accgaatggt 2920921 cgtggacgcc ggaatggtca atacacacgc aatcgccatt ttcatcaata cagcggctta 2920981 catgccgtta accgtattct tatattcagg ctttatccga tcgaccattc caaaagagct 2921041 tgtagaagcc gcaagaattg acggtgcagg catgctgaaa atctttttta cgattgtgtt 2921101 tcctctgctg aagccgatca ctgcgaccat ctgtatcatt tcttgtgtct ttatttggaa 2921161 cgactatcaa tttgccattt tctttttaca agatcaaaag gttcagacat taacagtagc 2921221 catggcaggt tttttcggag aaaacgcaaa caaccttcat ttagttgccg cagcggcact 2921281 tatggcaatg ctgccgatgg ttgttctgtt tttggcgctg caaaaatact ttattgccgg 2921341 cctgtcttcc ggagcggtaa agggttaaca ttaaaggggg aagcaatatg aaaaagatta 2921401 catttatcgg tgcagggagc acgattttcg ccaaaaatgt tttgggagac tgcctgttaa 2921461 cagaggcact gaatggattt gagttcgctc tttacgacat tgatcccaaa cgcctgcagg 2921521 aatcccagct catgctcgaa aatctaagag accgttataa cccaagtgtg gccatcaaca 2921581 gctatgatga cagaaaactc gccttgcaaa acgcaggcta tgtcatcaat gcgattcagg 2921641 ttggaggata caaaccgagc acagtcatcg atttcgagat tcctaaacgg tatgggctgc 2921701 gccagacgat cgccgataca gtaggcatcg gcgggatatt cagatctctc agaacaatcc 2921761 cggtcttatt tgatatcgca aaagatatgg aggaaatgtg ccctgacgca tggttcttaa 2921821 actatacaaa tccaatggcc actcttacag gcgccatgct ccgctatacc aatatcaaaa 2921881 caatcgggct ctgccacagt gttcaagtgt gcacgaagga tttatttaaa gctctcggaa 2921941 tggagcatga cggaattgag gaacgcattg cgggcattaa tcatatggct tggcttttgg 2922001 aagtcaaaaa agacggcaca gatttatatc cagaaatcaa aaggagagcg aaagaaaaac 2922061 aaaaaacaaa gcatcatgat atggtgcggt ttgaattaat ggataagttc ggctattatg 2922121 tcacggaatc gtccgaacat aacgcagagt atcacccgta ctttattaaa cggaattacc 2922181 ctgaactgat cagcgagctg caaatcccgc tcgacgaata tccgagaagg tgcgtcaagc 2922241 agattgaaaa ttgggagaaa atgcgggatg atatcgtcaa taataaaaac cttacgcacg 2922301 aacgctcaaa ggaatatggt tcaagaatta tagaagcaat ggaaacaaac gaaccattca 2922361 ccttcggagg aaacgtcttg aatacagggc tgatcaccaa ccttccttca aaagcggttg 2922421 tggaagtgac atgcgtcgcc gacagaaaaa aaattacacc gtgcttcgcc ggagaactgc 2922481 ctgagcagct tgcagcctta aaccggacga atattaatac acagctgatg acaatcgaag 2922541 cggctgtcac acgaaaaaaa gaagcggttt accaagctgc aatgcttgat ccgcatacaa 2922601 gcgcggagct ttccatgaag gacatcatct ccatgtgcga cgatttattt gcagcacacg 2922661 gcgattggct tccggaatac aaataaaaac taggggaccg ctctccccta gttttttggt 2922721 tttgtttcgc cttcccaggc catcatgccg ccttcaacat tgactgtttt aaagccttgc 2922781 tcatccaggt acttgcagac gttcatgctg cgcattcctg agcggcagat aaatacgtac 2922841 tctttgtctt tatcaagggt ttccattttt tcaggaatat cccccatgcg aatatgaacg 2922901 gcttgcggga tcatgccttc cgctacctct tcatcttctc tgacatcaat taaatataat 2922961 tcttcgtccg cctcaatttt ttctttcaaa gcggctgtgc tgatttcttt tatttccaaa 2923021 gaaaacactc ctattcacag tgatcatgtt cagtatatca aagtcagccg aacgattgct 2923081 attctgagac tgatgaaaaa aaatcccctt ttggcaaagg ggattttttc taggcttagt 2923141 ttgccacaat attgacaagc ttcccaggca ccgcgatgat tttccgaatc gttttgcctt 2923201 caagctgctc tttgaccttt tcatctgctt gagcaagctg ttccagctgt tctttcgttg 2923261 catcggcagg aacctgtaat ttcgctttta cttttccgtt cagctgaaca acgatttcaa 2923321 cttcatcatc cacaagtttt gtttcatcat atacaggcca agcttcgtag gcaattgtgc 2923381 cggaatggcc aagcttctcc catagctctt ccgctaagtg tggcgcgaca ggagaaagaa 2923441 gcttcacgaa gccttccata tattctttcg gcagttctgt tgctttataa gcttcattaa 2923501 taaagaccat cagctgggaa atacccgtgt tgaaacgaag gccttcataa tggtctgtga 2923561 ctttcatgac cgtttcatga tagacgcgct ccaatgtttc acccgcgcct tcaacgattt 2923621 ttccattaag ctcaccgctg tcttcaataa ataggcgcca tacacggtca aggaaacggc 2923681 gcgcaccgtc taatcctgat tcagaccagg cgattgaagc atcaagaggt cccatgaaca 2923741 tttcgtacaa tctcagcgta tcagcaccgt gagaggccac gatttcgtca ggattgacaa 2923801 cgttcccttt agatttactc attttttcgt tgttttcgcc gagaatcatt ccttggttgt 2923861 acagcttttg gaacggttct ttcgtcggca ctacgccgat atcataaagg aacttatgcc 2923921 agaagcgggc atacagaagg tgaagcacgg catgttctgc accgccgata tacatatcga 2923981 ccggaagcca tttttccaat ttttctggtg atgccagctg atccggattg tgcggatcaa 2924041 tatagcgcaa gaaataccag cagcttcccg cccattgcgg cattgtattc gtttctcttc 2924101 ttcctttttt ccctgtctca gggtctgtga cttccaccca ctctttaatg ttcgcaagcg 2924161 gtgattcgcc cgttccgctc ggtttgattt catccgtttt tggcaaaatc agcggcagct 2924221 cctcttccgg gacagctgtt gacgttccgt cttcccaatg aatgaccgga atcggctcgc 2924281 cccaataacg ctggcggctg aagagccagt cacgaagacg gtacgtcact ttcttctcac 2924341 cgtttttcgt ttcttccagc caagcgatca ctttttcaat cgcttcctgt ttgtgaaggc 2924401 cgttcaggaa atcagagttc acgtgctcgc cgtcgccagt ataggctgct tcctcaacgt 2924461 tcccgccttt tacgacttcc ttcaccggaa ggccgaatgt tttggcgaat tcaaaatcac 2924521 gctcatcgtg tcctggaact gccatgacag cacctgttcc gtatgatgca agaacataat 2924581 ccgcaatcca aatcggcagt ttttctccgt ttacaggatt gatcgcatac gctcctgtaa 2924641 atacgcctgt ctttgttttc gcaagatctg tgcgttctag gtcactcttt gattgaattt 2924701 ctttgatata agcttcaaca gcttcttttt gctctgccgt tgtgatgttt tccaccaatg 2924761 cgtgttccgg ggcaaggaca gtgtatgtag cgccaaacag cgtatctggt cttgttgtaa 2924821 acactgtaaa ggaatcatca tgtccatcta tagcaaaatg aacgtgagcg ccttccgaac 2924881 ggccgatcca gttgcgctgc atatctttaa tgctttccgg ccaatcaagc tcttccaagt 2924941 cctcaaggag cctgtccgca taagcggtga ttttcagcat ccactgcttc attgggcgtc 2925001 tctctaccgg atggccgccg cgttcgctct tgccgtcaat gacttcttcg ttggcaagaa 2925061 cagtaccgag cgcagggcac cagtttacag gcacttcgtc aacgtaagca aggccttttt 2925121 cgtatagctt taagaaaatc cattgcgtcc atttatagta ttcagggtca gtcgtattga 2925181 tttcgcgatc ccagtcatat gagaagccaa gcgcttgaat ttggcggcgg aagttatcaa 2925241 tattctgctt cgtaaacaca gcggggtcgt tccctgtgtc aagcgcgtac tgttcagctg 2925301 gcaggccgaa tgcgtcccag cccattggat gaaggacatc atagccctgc atgcgcttca 2925361 tgcgggacag aatatccgta gctgtgtatc cttcaggatg gccgacgtgc aacccagctc 2925421 cagacggata aggaaacatg tccagcgcgt aaaatttttg tttttcatta ttatcaagag 2925481 tggcaaatgt tttgttttca agccaatatg tctgccattt cttttctatc tctttgtgct 2925541 gaaaactcaa agtaaaaacc tccttctgat tgaatacggc gtgtatggtt caagtattga 2925601 cgggaaggag aggattatat tcagaatatt cccaaactaa aaaaaactcc ctcatcccaa 2925661 aaagggacga gagactttcg ttttcccgcg gtaccaccct cgttagcgcg gcatacgccg 2925721 cactcacttg atacttttaa cgcagttatg cgtcagcggc ttttcaccgc tgcaactctg 2925781 aggtgagttc ggaaacaaac ttgattgact ttcaccagcc gtcaactctc tgcaacaata 2925841 tctgtttctt actgctcctc ttcattgttc ttatcgcaac cgtaatctaa ctgtatttta 2925901 tagaattctg ttcataagtg caagcaggtt tgtatacaat gggaatgtac cctgaacggg 2925961 cggagattga ggacaattat tcgggtggag ttttggtttg acgtttggac tcggccggtt 2926021 cgccgccgct gttcagttct ctcacaaagt caaaacttct gagaacagct tcaccgccgt 2926081 agcctgagat aatggataag atgacaagtt gaattcctga atcggggtca gcggataata 2926141 caagtaaaat ggaagccgtc atgccgataa accaatcttc caaaaatcca aggtagataa 2926201 accgcttcgt cattctgggc ttctccagcc tgcctctctt tttcacatga ccgagaatcc 2926261 ccatgattcc tccaattaca caagcaatga gtacctgatg cagcatcttc atcatcacct 2926321 tcctaaagcc cttatttcgt aaagcgactt caggccatcc agccccctta aacgattccg 2926381 atgattttcg atatctacat accggcaaat ctgtaaaaag cttgtttctt ccattatatg 2926441 tgaacacatg atcggtaagc ttgatgcatt ggattcattt ttcacccagt gacattgacc 2926501 tagtcaccta tttagcatgt agaaaacctt tccgttcata tgttcaaatt ctgttcttat 2926561 ttttagtgta tacgaggaca agccctaatg acaaacaaca aactgcactt gcttgaatca 2926621 gaacatgtgt tgtgctacgg ttactgtaga attcattttt aaaaagggga atatcaggct 2926681 ttcgcatagc aagctgacgg cctaaggggg atttatatgg ctagttttca atcatttggg 2926741 ataccaggac agctggaagt catcaaaaaa gcacttgatc acgtgcgagt cggtgtggta 2926801 attacagatc ccgcacttga agataatcct attgtctacg taaatcaagg ctttgttcaa 2926861 atgaccggct acgagaccga ggaaatttta ggaaagaact gtcgcttctt acaggggaaa 2926921 cacacagatc ctgcagaagt ggacaacatc agaaccgctt tacaaaataa agaaccggtc 2926981 accgttcaga tccaaaacta caaaaaagac ggaacgatgt tctggaatga attaaatatt 2927041 gatccaatgg aaatagagga taaaacgtat tttgtcggaa ttcagaatga tatcaccaag 2927101 caaaaagaat atgaaaagct tctcgaggat tccctcacgg aaattactgc actttcaact 2927161 cctattgtcc cgattcgcaa tggcatttcg gctcttccgc tagtcggaaa cctgacagag 2927221 gagcgattta attccatcgt ttgcacattg acgaatatct tatcaacatc caaagatgat 2927281 tatttgatca ttgatttatc cggattggcc caagtgaacg aacaaacggc cgaccaaatt 2927341 ttcaagctga gccatttgct gaaattgacc ggaactgagt taatcattac tggcattaag 2927401 cctgaattgg ctatgaaaat gaataaactg gatgccaatt tttcgtcgct gaaaacatat 2927461 tcaaatgtaa aggatgccgt taaagtgctt ccgattatgt aaaaagatcc cgctcaccca 2927521 gctggatctt tcagattgtt gacaaaatcc taaaatggtt ttcattttag gattttgtca 2927581 tcttttcagc gtgattgaaa acccttgaag tctaggaagg acgagcatag gagcggagcg 2927641 aatgttctaa ttcgtgagca ccgaagcgca ggcctgacaa cgaatgcgag ggtttgtcga 2927701 cacgctgaaa gatcccgctc attcggcggg atcttttatt atgaagagat tgatgcctgc 2927761 ttatttgttt ctttagctga ttttatccgt ttgtcatata gaagcgttgt ggcaatactg 2927821 atcagcagca ataccaacag agataaaaca agagccctaa tgccgtaatg atcgacaagc 2927881 actcctccga acaggggacc aatcattctg ccgcctgtcg ccgcactgtt gacaaagcct 2927941 tgataaaagc cttctttccc tttaggggca agctgattgg caatagtcgg cacagcaggc 2928001 caaacaagca tttctccgat agtcaggatc accatcgcag cgagaaacat cggaaattgc 2928061 tttgcagtca gcagcatgct gaaagacaca ataaaaatga taaagccgat gaccatttgc 2928121 gcttttagcg actcggccca ttttttcacc acaaaactga cgagcggctg gccgagcaca 2928181 atgagaattc cgttaaccgt ccacagcacg ctgtataagg aaagagatat tccaatgctt 2928241 tgtgtgtacg aagcaattgt ggttgaccac tgagaataag ccagccatcc gagtacatag 2928301 cctccgctta aaatgatcag tgcggcaaat tttgctttgc tgttcacagc atcataatca 2928361 agcacggatg tttgggatgc atcgcccgtt tgaatatttc gaaatccgaa atatacaata 2928421 aagaaaaaga tcagatacaa tacggcattt gccaaaaata catatgaaaa cgagaaagat 2928481 gccacgacac cgccaagcgc tgaaccaacg gccacgcccg cgttttgcgc gacatatatc 2928541 gcattaaatg ccttccttcc cccttcaggc cataccgatc ccgccattgc gtagcttgcc 2928601 ggaaaaacaa caccggagcc aaagcccaca atcgtcagca gcacaatata ggctggccaa 2928661 tcatgaaaaa agacaagacc catcaggctt gctaacgtaa tggctatccc aagcataatc 2928721 gatttaaaac cgccgatttt atcaaacaaa aaacctccgc ataaattgcc agccacactg 2928781 gcgccggaat tcagcatcag gacaagtccg gctactgtta acgactttcc taaatgatta 2928841 tggatataaa tcgtattcag cggccataaa aaagaagcac ccgtcacatt gataaacatt 2928901 ccaatgacta aaattttaag agcacgcggc atactcatcc ccctttctta cctaaaaaag 2928961 ctcatgaaaa aaacgaaacc taaaacggct ccgtacgaat ccagttatca tagcacattc 2929021 attctatctg tctctctcac atttttcaac tgatgagcgt gaaaaaatct aacaaatatt 2929081 gtttgaaaaa tgtaaaataa atagaaaaag gggtcatatt atggaaatgg tattagcatt 2929141 cttaggtttt ctggcatgtc tcattgcact gggctatgga ttatatcacc ttgtcagata 2929201 tgtactgaaa aaggaaaaac gtttctcaaa gagacttttt tggccgcttt tcattggagg 2929261 ccttgtgctg ctctttaccg gggcagcatt ggcagaacct gacactgccg cagcaaatgc 2929321 cgagaaaaaa tattcagcgc taaacgccga atataaaaac ctcacaaaag agcacgaaga 2929381 acttgagaaa gaatataaat ctgtcagctc tgaagcaaag aaattaaaag acaacaaaga 2929441 agatcaagac aagcttgaga agcttaaaaa cgaaaatagc gatctaaaaa agactcagaa 2929501 atcattaaaa gctgagatta aagagcttca agaaaatcaa aagcagctca aagaagatgc 2929561 aaaaacggca aaggctgaaa atgaaacact tcgacaagat aaaacaaagc ttgaaaatca 2929621 attaaaagag acggaaagcc aaaccgccag ctctcatgaa gacactggaa gttcttcaaa 2929681 caatacgagt aaaagtgatg aaaccaaaac agctgacaaa gcagaaggct gtaatatcaa 2929741 aggaagcaga aacggcatct accacacgcc aggcagtaca tactacgacc ggacaaccga 2929801 tccggctgaa atgttttgct cagttgaaga agctgaagcc gccggttatc gggcgccaaa 2929861 acgataaaca aaaagctcca gaatgtctgg agctttttct gtttcacaac gacgatttaa 2929921 tgaccttctt ataataaaga actgacagaa aaccaaaaat ggagtagagc gcagtatata 2929981 acaccatcac cataatcata ggcgcccata cctctgatcc gaataagaac cagccggatt 2930041 ggacggcaaa gtaactgtgg aagaggccga caacgagcgg aatgccgaag ttgtacattt 2930101 gtttgatgcg tatccccttt atcaggtcgc cctgcgtaaa gccgagtttt cttaaaattg 2930161 tatagctcgg tttttcatct tcactttcac ccatttgttt aaaataaagg atacaacctg 2930221 atgtaatcag gaacgttaac cctaagaagc cgacgatgaa catcaccata ccaaacagtg 2930281 atttttgcgc agcgcttgta tctagtcttg ataaatgctc gtttttcttg ttcacctgtt 2930341 gaaaaagctc atttgctttt tccatttgat cgtcatgttt cacattgacg ccgataaatg 2930401 tagattgcgc cagctgaatg cgggggtctt tatccttgtc cagctgttta aacaggctgt 2930461 catccacaat gacagcgggc atgcccccgc ttgtaaacgt gtaggacaca agaaactctt 2930521 ctcttaatcc tttatatttt aatggctgcg tctcgtgctt gctttttact ttaataacac 2930581 cagagtcctt gaaaaccatt attttttgca gcaagtcggt gtatcctgag aaaacggctt 2930641 ctccagccgc cacatcgact ccttttacat ctttgtcgct aacaacagca agctgcatat 2930701 tgccgggatc gccctgcatc tctttcggag ttccatccat aatatttgca atgtcaacat 2930761 ttgcttgcag gacaggtgtt gcctttttta caaacgagat gttgctttcc ctcaatttgt 2930821 tttcaaataa cttggcatct ttctcattca tgaatgaaaa atcagccgct acattttgtt 2930881 cagcggtctt ttccgacgag taatacgaga tgtaagcaag agataacagc ccgatggcga 2930941 gcgctgaaac ggttgtaata atcgtcagca gcagcgcatt cgatttcatt ctgaacatga 2931001 tcgaagacag tgacagaacc tcagaaatat ttaagtagcc gcccttgctt tttcgaatga 2931061 tattcgagat aaacgtaact gatcctttat aaaacaaaaa cgtcccgata atgacgctcc 2931121 ccagaatgaa gctcatcgca acaaacagtt cattaatggt cttaaatttt ccgccaaaca 2931181 gctcagaaga cacatagtat cctgtcaaaa tcaacacgat gcctaaagcg ccgatcagca 2931241 tttggaaaaa tgatattttc ttcactttgt cttcagtgga ggacgttact ttaaacaaag 2931301 ataaaatact ctgttttttg ataaacgtat aattcatgat catgatcaaa aggtaaatgc 2931361 cgcagaacac aatgaccgtt tggaccaagg cctgctcaga aaaatgcagt ttcgcatccg 2931421 ctttgacatc gacaattttg aacagaatca tcaagacaag cttcgatatc gaaaacccgg 2931481 ccgctacccc gatcgctaat gaaccgaaat acagcatgac attttctgca cttaagatgc 2931541 gaaaaatttt atgcttcgtc attccaatta attgaaacag cccgatttct ttactccgtc 2931601 tcttaataaa aatcgtattg gcatataaaa tgaagatcgc cactacagcc acaagcaaaa 2931661 tcgaagcggt tttaatagcc gcggctccct tgattgaagc cttcacttcg ttaattgctg 2931721 gatcatactg cagcgtgaca aaggcgaaat aaagcgccac gctaaagatg agcgcaaaca 2931781 catacaaata gtaattccgg agattctttt tcaaatttcg caggatgagc tgattaatgt 2931841 tcatgctgca ccccgcctaa cacgccttgc gttttcataa tatcctggaa aaacgtttgc 2931901 ctgtcctggc cccctttatt cagctgtgta tacatttgcc cgtccttaat aaaaatgact 2931961 ctgccgcagt agctggcagc gacgggatca tgggtaacca taataatcgt cgcgttgcgt 2932021 ttttgattga gctggctcag cttatttaat agatcggagg ccgatttcga atcgagcgcg 2932081 ccggtcggtt catcagcgaa aataatgctc gggtcatgaa taaacgctct tccagcggat 2932141 gttctctgct tctggccgcc ggaaatttca ttcgggtatt tatcccgcaa ttcatatatt 2932201 cccagttcct tggcaacttc ctcaaacttg cgattggctt ccttttttga tagtttcgtg 2932261 atcgataaag gcagaaggat attctctttc actgtcaatg tgtctaacaa attgtaatcc 2932321 tgaaagataa agcctaaatg ctgttttcta aattcagcca gctgcttttc cttcatagcc 2932381 gtcatgtcat ttccattaat atgaatggtt ccgtgactga cctgatcgat tgaggacaga 2932441 acgttgagca aagtggtttt tcccgacccg gaagcaccca taatactgac gaattcgccc 2932501 ttttcaatgt gaatatcgat gcccttcagc acttcctgtt tattcagctt gtttccataa 2932561 ctttttcgaa ttttattcgc ttctaaaatc accatttacg cagtctcctt tatattggat 2932621 aatctcatta taaaaaggaa tgccgggctt ttccttcgat acggcgaaca aaaaagaaaa 2932681 gcatgtgaca ttttcgtcac acgcttatga catgttcaaa ttgattccgt attggaaagg 2932741 ttaatgtaaa aactgttccc gcaccaaact ccgactcaac atcaatatgg atcaataacg 2932801 gcgccgctgc tttttttgcc aagtacagcc ccatgccagt tgacgcttga tcatggtgat 2932861 ccgttgtgga tgtaaaccct ttatcaaaaa tacgcggtac atcttttgga tcaatgcccc 2932921 tgccacaatc tttcacttgg agctgcgtct gttccccttt ttgaaagctt ttgatctcga 2932981 tttcagaggc ttcgctgtat ttcaccgcgt ttgtcagcag ctgcctgatg ataaacgcca 2933041 gccattttgc atcgctcagc acttctttgg cctcgagctg tatgtcaaaa ccgatccctt 2933101 tttggataca ccacgattgt aaatctttga tttctttaaa gatcaaaggc tgaagctgaa 2933161 tgaattctac tgacaggtcg ttttcaataa atgaaatgcg tttttgatga agctgctgat 2933221 caagaagcag gtgaatacgc agccattcat atgacagctg ggatttcagt gctttttctt 2933281 ccattctatc aatgattaaa tgcatcgctg ttaatggagt tttgacctca tggatccatg 2933341 ccatcagctc atctttttca ttttccaatg ctaagcgatg ccgtgctgcg gtctgcttca 2933401 agtgttctgt ttgcccggca atgcttcttt caaccattgc ttcaaacggc gtttccggtt 2933461 catttatggc tgtcacatcg agattgttct cccatgtttt caagctttta taaaacgctg 2933521 tttctttccg atagcggaac caaaggaata tgataaaaaa caagatgcac aaatacacca 2933581 tataaagtac attcccaaat gatatggaag gatcgacaaa agcaatgaac agcatcaaag 2933641 cctgctgaaa caaaaacgcg gcaatccagc tccgcctttc gataaggaat gctttaatca 2933701 tagaacttgt cctcttcctt cgcgatgtag ccctggccca cctttgtctc gatatatgca 2933761 ccaagctgca gggcgtccag tttttttcgc aggcgattga cattgacggt cagcgtatta 2933821 tcactaacaa aacgctcatc gttccacaag cttctgatca gctcttcccg gctgacgatc 2933881 ttgttttttt gctctattaa ttgttttaga atgaacattt catttttggt cagttcaaca 2933941 gatcctttgt cattgctgac gaggttctgc tccgcgtcta cagcagcgcc gcaccacgtt 2934001 ttaatcgtac tcggctccgt attataatgg tgcacacgcc ggaacatcgc ttggattttc 2934061 gcgatcagca catcaaaatg aaatggcttt tgaataaagt catctgcccc gagctgcatg 2934121 gacatcacca tatcagcagg atgatcccgg gaggataaaa agagaatcgg aacatttgac 2934181 cgggagcgga tcagacggca ccaatgaaag ccgtcaaatt taggcagctg cacatcaata 2934241 atgacacaat caggattaac cgccgcaaat tcctgcagca cctgactgaa atcctgaatg 2934301 ccgtatacat cataggacca tcccgttaaa cgatccttga tttcatgaaa cagcgattca 2934361 tcatcttcaa tcagcaaaag tttaaacaat cgactcaccg cactttttcc ttttttatca 2934421 agtgtatagc aaaacgccag catgcgctat agaaaaagcc ggctgtctca gccggctcgt 2934481 tcgcattata attctcttct caacgctgtc agcacgttgg ttttggtagc ttttctcgcc 2934541 gggttcattc cggaaatgac tgcgacccct ccgcaaatca caacggcaat gatcacaagg 2934601 ctcgccggga tgtaggagaa tgtgtaattc aaatcgcccg catcgccacc gcttgtggcc 2934661 gcaagaatca tcggaacggc caggttgaca aggtagctca cgccgtaaga aatgataatc 2934721 ccaatcacac agcctaaaat tccgatatac gcgctttcca tcaagaacat tcggcgaatg 2934781 attgacgggc tcgccccaat cgctttcata atgccgatct cttgcgttct ctctgtcacc 2934841 gccatcgtca tcgtgttaaa aatgccgatc gctgaaatga taactgcgat acatccgaca 2934901 aagatcagtc cgattttgaa gaccatgaag aaggtattgg ctccctcaag ttcagtagtc 2934961 actgatgtga catagtaccc gtcatctgtt agatcatttg tcagctgttc cacattctca 2935021 aacttatcag caaaaacacc aatgttcgtt tcaacatttc cgcctttgaa atctaagaat 2935081 tccgaaaaat cttttttgaa ttgatcactg ataaaaatat ttgagtcctc catccagtct 2935141 tgagatggtt tttttgtaat accgacaatt ttaaagtcat atgtttttgt ttttgtaaca 2935201 tcccctgttt tagaatctgt cttcgataca cttagttcaa ttgttttatt tagaatatct 2935261 ttcgtatagc cctttggttc ttttatatct tctggatttc cttttgcttc ctcgattttt 2935321 ttgttatatt cttccgattc ttttttcgtt aataatctct ttgcgaagtc gtatcctact 2935381 acgatttcat tttccgactt tgcgactctt cccttttcca attccatatt ggcctttaat 2935441 tcatcattca tattagtaaa aatgagattt gagctttcat ttgtacgatt gcctaaagta 2935501 gctttgtttg gttcatacac ttgcgttctt tctacaactg accttacgtg atcatacttc 2935561 tctaaatcag cttttttaat cggcttgtct ccttccttgc ccattacgct gactttcgtt 2935621 acaatctgct ggctcattgt catatctgta atcgtctttt gaatcccaaa tccaacggac 2935681 gacaacacaa ccaaaaacgc acacgccatt gttgtcgcca gaatcgtcat aaagacgcga 2935741 agcctgtttt tcttcatatt tcttctgata aaatgaacct gatccttaaa cctcaacggt 2935801 aattcctcct tttagcacac catcatgaag ctgaaatttt gaatgtccga tagaagcgac 2935861 ttcatcatcg tgagtaatga tcacaaatgt aatgccacgc tcacgattca gctgctggat 2935921 caattccagc acttcatgtt ccgtttctga atcaaggctt cccgtcggct catccgctaa 2935981 gataatcgaa ggatttaaaa tcaatgctcg agcaatactg acacgctgct gctggccgcc 2936041 tgacagttca ttcggataat gagcggcgtg gttttccaga ccgacgcgtt tcagcatgtc 2936101 ctgcaccttt tgcttccgct cagatggctt gattcctttt aacgccagcg gcatttccac 2936161 attctcatac gtcgttaaac ccgggatgag ctgaaagctc tgaaaaataa acccgaaatg 2936221 gtcaagccga aattgcgccc attccttttc attaaacccc gtaacatcag tgccattaat 2936281 gacaatccgc ccttttgtcg gcgatatgta gccggaaatt aaattcaaaa gcgttgattt 2936341 ccctgagccg cttcgtccga caatgcaggc gatttcccct ttcgccacgc tcaatgaaac 2936401 atccttcaat actggaactt cattctcacg gccctttttt ccgatcgtga aagaatggtc 2936461 gatatgctga acatcaatca tatgttctct ctcccttaca aaagtttcat ttttttataa 2936521 atcgcaaaat aactaatcaa gaaaccgatt accgcacctg tacccatgcc aatgagataa 2936581 ccggcaaagc tctcgcttgc agtaaatcca aaatagccga agcccatgat tcctatgata 2936641 ataacgatga tctgcaccgg gcggttaagc ggcttccata agaagaaata tccgtttctt 2936701 tcattagaca ttttaacaaa gctaatatag ccgatgatgt aaaaaatgat agtcatgata 2936761 gccggaatga ctaaataata tggtgaattc tcagcccatt tcgagtctac ataaattatc 2936821 ggaatgaaat actgcaccca tttaggtact ggaccatgga taaaatctat tgatccgcca 2936881 aaaaggatct cgaggttgat cacaggcagg ctgatgagta aaaacggcga aatggccacg 2936941 gtaaatgaga ctagaagctg tgcgaaacta ttgcctgtca aagctcctcc ggccataacc 2937001 aaagaataag ccagcatgct aacaataatc attcccaagc tgtaattgtg aaaataaacg 2937061 gcctgatctg gcttcaaaag catgatcagc aaaacagaca aaacataacc tatgagctgc 2937121 ggcaccacaa tcaccattcc gccggtaagg aacttcgcat gaaatatctg ccctcgtgta 2937181 tatggaaggc ttaatgtaaa atcaaagaag ctcttgctac gttcaatccc aagctggctg 2937241 accgccaaaa cgactcccca aatccaaaac aatgagataa atgagctatt taaataatca 2937301 acgctgaata cgcaggggcc gacccaattt tcttttccag tgacacagcc ttgatagatg 2937361 agatacatat ttaaaattga taatggatta cctaatataa aaaccaaaat ggtgataact 2937421 aaggcgactt tattctgccg ccactctttg taaagcagtc cggaatccgg caactcactt 2937481 ccctccaaac ctaaggcatt tcttacactt ttgttttctt ataaatagag aagtagctca 2937541 caaagaatcc agccactgct ccaatgatca tacccaaaat ataaccaata atggaatgtc 2937601 cggtatagta tccaaataaa ccaaatccaa ggatgccgaa agccataacc agaatttgca 2937661 ccgggcgatc taatctgttc cataagaaaa agtgtccgtt ccgttcactt ggaagcttct 2937721 tgaagcttat aaagccaatc aagtaaaata gcatgctcat tacggctgga atcaataaaa 2937781 gatatttact gttaatcagc cattcattta caacgtaact aatcggtact aggttcgata 2937841 aattgcttgc cagagagaaa taactctcag gggaagggaa tatttcccat atattcgcac 2937901 caaaaacaac ttctaggttt ccaaccggca atgcaataat taaatacggc aatatagctg 2937961 ctgaaaacgc cgttaacagt tgggcaaaag catttccagt taacgctccg gcggccatca 2938021 ccagtgaaaa agccataaaa cttatcacga ttactccaat gctgctgtgc tcaaaaaagt 2938081 agacgtgttc agggttatag acaagaatca gcagccatgc aagtaaaaag ccaatcaatt 2938141 gtgacagcac aatcacaaaa ccgcctaacc aaaattttgt ctgaaaaatt tggcttctgt 2938201 tatacgggag gcttaatata aaatccatcg tgcctttcga acgctccatt ccgaggaagc 2938261 agaccgccaa aatgacaccc ggcacccagt tgatatctat cagattgctt atggaataat 2938321 tcacaataaa atcacaatat tgcgggtctt ggcgatcaag acacccttga taagacaaat 2938381 acgtattaac gatagaaagc ggatttgcca atactaaaaa cgcgatactt aacaaaatca 2938441 ccacttgatt ctgcttccac tctcgataga ggagacctcg gtctaccatc tccgcttccc 2938501 tccaaacttc gcaatgaaca cttcttccag gttgacagga agctcattcc acacttttgg 2938561 cttcagctct ctcaaaaagc tctttttctc ctcatcgctt ttcggaatca gcactgtgta 2938621 aaacacgccg gcctgatcga gcatcggaat gttttgctct ctgatggcca aattgacatc 2938681 tgtatcgaag gccatttgaa ttttaatgta ttcttctttt aactcatcaa gatccatgac 2938741 gttggtcagg ctgttatctt caagaaaacc aattcggttg cacatccgct ctatgtcttc 2938801 aagccggtgg gacgtaatca ggatgctcgt atcacgctct gccacttcat cgaccatcag 2938861 ctgcagcaca tcatgccttg tcaccgcatc aataccatcc gtcggctcat caaggaggat 2938921 cagcgccggt ctcgccgcaa acgacagaac gagcgatagc tgctttttta agcctgtcga 2938981 cagctcacgg tattttttcg tttccggaat ttcgtatctg ttcatcagct cattcgcgta 2939041 cgtgacatca aatttcggat atattcttct caaaatatcg actaactgct tgtatgtata 2939101 cttatcgtaa aacggatttt gaacaggcat gtagatgata ttttgtttga ctttcgggtg 2939161 ctttttgatt tctacgccgt caaataaaat cgttccgctg tcagcgaaaa tgatttgctg 2939221 gattaagcga agcatcgtcg ttttgcccga tccattgcgt ccaagcaatc caaagatttc 2939281 tcctttttcg attgttaatg aaacatcttt taatacttga ttgccgtcaa tcgcttttga 2939341 cagctgccgc agttcaatca ttttttttgc ctcccttcac atcagcgctg atttccttta 2939401 tccattcgtg cagtttttcc agctcaaccc ctgcatagtg tgcatcgatg atgagctgtt 2939461 tgagttgctc tttaatcatc gtcatcttcc cttcaaccag tgtcgttttt gcattctccg 2939521 atatataggt ccctctgccc cgcagcgttt caataatccc ctctcgctca agttctttat 2939581 acgctttgct gacagtgttc ggattcgcaa taatgatcgt tgccaattct ctgacagaag 2939641 gaagcttatc accaggcttc atgatccctt tcaaacaaag ctctttcatt tgctgaataa 2939701 tttgttcgta aatgggtgtt gagcttcttg gatcgatttg aatcatttac ttccctactt 2939761 tctatacgat ctgaaccttt tatagataaa aatgatcaat tatacttttt tgccattcaa 2939821 aaccgatcat cacaagaaca agaaaaaaag aacaagcgat cacagatgcc gcaatcagca 2939881 ttggcacgtt acgtttgttt cgttttttat gtttcataac tgcctccctt aatgtcaata 2939941 tataaatgat tttatattag tgtctatagt gtattacttc aattagtaca cttaatacaa 2940001 taaatacttt gactcacaaa gtcaatcctt tttttacaaa aaaacggacc cttttaaaag 2940061 ggtccgtttt cctacacatc aagagggtgc tgcaggatca tattattttg caaagattga 2940121 agctgaagtc tcattctgta cagctgttct ctctgctgat catttgacga cagccatagt 2940181 ttattcaagg catttaccgc atcttctagc tgcatttgtg catcactata ttcttgatcg 2940241 ttataatgct cttgtttaga agcgattttc agctgttctt cagcataatc ataggcctgc 2940301 atacattgct ggagatgttc atctactgat tgtcttgttg ccacagtaac ccctcctctt 2940361 ggtaatggaa atcatccatc attcatattg tagcctcatc tgactttatt caataaagta 2940421 atttatggtc gatattcatt tgttctcttg tgaaatgcgt gctacaattt taggatgcaa 2940481 tcgtacgcaa ggaggcacat gaattgtgat gcagaacaat ccttttcctt attcaaatac 2940541 ggaaaaacgc tatcatacat tgaattatca tctcagagaa catttcggcc ataaggtgtt 2940601 taaagtagcg cttgacggcg gttttgactg tccaaatcgg gatggcaccg tagcccacgg 2940661 aggctgtacg ttttgcagcg cagcaggctc cggagatttt gctggaaacc ggaccgatga 2940721 tttaattacg caattccatg acatcaaaaa ccgcatgcac gaaaaatgga aggacggcaa 2940781 gtacatcgct tattttcagg ctttcacaaa cactcacgcc ccggttgagg tgcttcgtga 2940841 gaaattcgaa tccgtcctcg ccttagatga tgtggtcggc atttcgatcg ccacacgccc 2940901 ggactgtctg cctgatgatg tcgttgatta cttggcagag ctgaatgaac gtacgtattt 2940961 gtgggtggag cttgggcttc aaacagttca tgaacggact gcacttttga tcaaccgcgc 2941021 acatgatttt aactgctatg tggaaggcgt caataaatta agaaaacacg gcatacgtgt 2941081 ctgctcgcat attatcaacg ggctgccttt ggaagaccgg gacatgatga tggaaacggc 2941141 aaaggccgtc gcagatttgg atgtccaggg cattaaaatc catctgcttc acctactgaa 2941201 aggcacgccg atggtcaaac aatatgaaaa gggcaagctg gaatttcttt ctcaagatga 2941261 ttatgtgcag ctcgtctgcg atcagcttga gatcattccg cctgaaatga tcgtccaccg 2941321 cattacaggt gacggaccga ttgagttgat gatcgggcca atgtggagcg tcaacaaatg 2941381 ggaagtgctt ggcgccatta ataaagagct agaaaatcga ggcagctatc aaggaaagtt 2941441 ctttcaacgg cttgaggagg aatcagcgct atgattttga agaaaattct tccttacagc 2941501 aaagaactgc tgaaaatggc cgcgggagag ggagatattg tcgtagatgc gacaatgggc 2941561 aacggacatg atacacagtt tttagcggag cttgtcggtg aaaacggcca tgtatacgca 2941621 ttcgacatcc aagaatcagc cgtggccaat acaaaggaac ggctcggtga catgtatcaa 2941681 gcgcgaacaa cgttatttca caaaagccat gataaaatcg ctgaatccct cccgcctgaa 2941741 acacatggca aagtggcggc cgcggtattt aacctcggct atttgccggg cggggacaaa 2941801 tcaattacga caaacggcag ttctacgatc aaagccattg aacagcttct cagcatcatg 2941861 aaagacgaag gtctgattgt tctcgtcgtc tatcatggcc acccggaagg caaagctgaa 2941921 aaaaacgacg tgctcgagtt ttgccgggac ttggaccagc aaacagcccg tgtattaaca 2941981 tacgggttta tcaatcagca aaatgacccg ccatttattg tcgccatcga aaaaaaagct 2942041 cagatcagca aatgatttga gcttttttct ttgaattttt catccaggac attttttgaa 2942101 atttccggta ggctctgccg ttgatataaa agaaaaggga ggtttttccg ctggctttga 2942161 tcagcttctt tgcgagccgg cccatttcct tttggcctgc cactttatca tctgacaaat 2942221 aaacgccaag caagccgcga ttgattaaac gatggaagtt ttcatgcgga atgccttgta 2942281 aatgctcgtc ggctttatgg ataaagtgtt caagccggtc catcatctct tcatgagact 2942341 gataatacga gcagaaattc aagtctcctt ccagcaagtc ctcctcttga tcaatcaaat 2942401 aatcaagaag aatatgaaga ccctgtatgt aaggaaaata actgtctcgg atttttttag 2942461 cggtgctttc tgtgaaatca ggctggaacg aatacgcaac cagacagaaa atgcctaacg 2942521 ttgagcctgc acaggctgaa aattcatacc attccatctc aggcagctct gattcatatt 2942581 gagtaaacca cttttcaagc cgcggaacac gctcatgctc aataacgtgc ttatgcacct 2942641 gcaaatcgca ataatagccg cacagttcaa gcagataagg tttaatcatg tcatagtgct 2942701 caatggagcc gagaacacgc tggcacgttt taaccagttc atgcaaatat ccgctgtcat 2942761 cctgttcttc cctgaattga taatagtttt gcagttccgc cccaactgtc agtgcgtcct 2942821 gcattgaggc atggagcatc cgaaaatcct gcgggtccag cgaggtgctg cggtcacaca 2942881 gattgtccaa ataatcacta atcgtttgat acgcgatgat aaactcgaca catttctgct 2942941 tttggctgcc tgacaataag gccagtatgc cgccgccttc acagtgaaac gttttgtccc 2943001 gaatacttgc ggttgcctgt gctttcaatt cactgttatg aatcgattct gatttttgct 2943061 tccatatgtc cagctcttga tgaacgagcg gaaaaatatc tcgatatacc tttgccatca 2943121 atccaaaagg atgttccggt actgtcaaca catgcacccc ctactagttc aaatatattg 2943181 atcagtaaac gctcttgctg ctttaaaaac atcttctctc tcgggttcat tgaagatctc 2943241 atggtaaagc ccttcccact ctctgtatgc tttattatga gaagcaacac cattaaacca 2943301 cttgatgacc atcgttttgt caacaagctt gtcatcaccg gcttgcatca caagaagcgg 2943361 aactttcaaa aatgcctctg tcggcaccat tgccgattca attgtcttta aaagctctct 2943421 gtaccatctg acagaaactt tcctgacgta taacgaatca ttttggtcag cttcgatgac 2943481 gtcctcattg cgcgtcgcca tatcaattga taatcccgaa tcaaccttaa gtgacggagc 2943541 gatgacattc aggccttttg atgcaagatc aagcgcttta ttcactttaa tttgcagtcc 2943601 gagacacggt gatgataaaa taattcccgt aatccgggga tttctttgct gtttaaccca 2943661 ttcaatcgcg accagaccgc ccatgctgtg acctagaaga aaaaccggaa gatcaaaggt 2943721 tcgcgcttta tctatccaag catctacttc atcaatgtat tcttgaaacg agcgaatatg 2943781 ccctctcgct cttgtcgttg ttccctgtcc aggcaaatcg cccatgacaa cgtgataacc 2943841 cgaagaccgc cacatttcaa tcagccattt atatcgtccg tgatattcac ttgccccgtg 2943901 aatgattaca atcacggcaa caggtctgtc tgctttccag gtccacatga tcttcacctc 2943961 atacgaaatt taaatagaga aagaaggatg aatcttatga tctaccctta taaggaacac 2944021 aagccagata tccacccaac agcctttata gctgataatg caacaattac cggtgatgtc 2944081 gtgatcggag aacagtccag catttggttt tctgttgtca taaggggaga tgttgcgccg 2944141 accagaatcg gaaacagagt caatatccaa gatttaagct gcctccatca aagcccgaac 2944201 aagacgctac tcattgaaga tgacgccacg ataggccatc aggttacact tcatagcgct 2944261 gttatccgca agaacgcctt aatcgggatg ggctcaatca ttttagacgg agccgaaatt 2944321 ggcgaaggcg cttttattgg tgccggcagt cttgtcccgc ccggaaaaat cattccgcct 2944381 ggccatctcg cctttggccg ccctgcaaaa gtcatccgcc ctttgacgga agaagaccga 2944441 aaagatatgc aaagaatacg gtcagaatat gtagaaaagg gccaatatta taaatttctt 2944501 caacaaacat aagacctgct tcgtcttact ttaccatttt tcaaattata tttgaaagca 2944561 ataaccatcg ttaacccgga cgtcatacag ttcgggtttc gatttttcca taaaacgttc 2944621 acatatagca tgaaacgtat gacttttatc ttatcacaaa actataaaca gcctctgcaa 2944681 aaacacatac ctattctttc ctgttctcta ttttctatga gcacacacaa aaagagccca 2944741 ctgggagctc tttttgtcag ctgatatttc gttcgctggc agcagccgca ttttttttat 2944801 gaaacccttt tccatagtac acagccagca agatgagaaa ccatatcggc ccgataatca 2944861 cggctactct tgtatcaggg ctgtaagcca taagaatgac gacgaatgct agaaatgcca 2944921 atgacacata agacgtaaac ggaaataaag gcattttgta ctttaattgt ttcttttctt 2944981 ccggcttcaa acttttcctg tattttattt gagaaagcaa aatgattgcc cacgtccaaa 2945041 tcgctccgaa cgtcgcaata cttgtaaccc aagtaaatac cttcgcaggg acaacatagt 2945101 ttaacagcac tccgactaat aaagcgcccg ctgaagccag aacagcttta cccgggatgc 2945161 cgcctttcgt cagctgacca tatgcttgtg gcgcctcttt ctgttccgcc aagttaaaca 2945221 gcatccgccc tgtgctgaaa ataccactgt tgcatgaaga cagcgcggct gtcaacacga 2945281 caaagttaat gatacctgcg gccgatggaa tgcccacttt ttgaaatgtg agaacaaatg 2945341 gacttccttg agagccaatt tcctgccacg gataaataga cataatgaca aataaagcgc 2945401 ctacataaaa aatcaaaatc cgccaaaata ctgtatcgat tgctttggct aacgattttt 2945461 gcgggttttt tacttcgcca gccgtcaccc cgatcatttc aatccctaaa taggcgaaca 2945521 tgaccatttg aagagacaat aaaacccctt ttaatccatg agggaaaaat cctccgttgt 2945581 tccacaaatt gctgattccg gttgcaatgc ccccattgcc gactcctgca ataatcatca 2945641 ataaaccgac agcaatcatg gataagattg caacaatttt aatcaatgcg aaccaaaatt 2945701 ccagctcgcc gtaagctttg acagccagga aattaacacc cgtcataatg accagtgccg 2945761 ataacgccca aatccagttt ggcacgtccg gaaaccagaa ccccatatag atgccgacag 2945821 cagtgatttc ggccatacag gtgacaaccc ataaaaacca gtagttccaa cctgttaaat 2945881 agcctgcaag cggtcccaaa taatcacgcg catacctgct gaaggagcct gcgaccggtt 2945941 tttgaatggc catttcccca agcgctctca taataaaaaa catgaccagg ccgcttgcgg 2946001 catacgctac caaaatacca ggccctgcta attgaatagc tgatgcggag ccgaggaaca 2946061 accctactcc tatagcagct cctaaagaca ttaaagaaat atgcctttct tcgagtccgc 2946121 ggtgcagctc ttgtttttgt ttttgcatgc ttcttctccc ctagaaaaaa atatcattat 2946181 atcatttttc tgaatattcc gtacggattg ggtaaatcaa tgatgatgga gaaataaaag 2946241 gataacaaca aggctttcga ctactcgaaa gccttgttgt ctgttacaca aagatgactt 2946301 ctttaggctg atggctcagc tcttcaggca tataccgttt ttcaatattg atgctgtgcc 2946361 agatcataaa gattagcaca gtccaaattt tacggctgtt atcagccttg tccgcacaat 2946421 ggtcttcaag aagctgaagg acataatcct tatggatata agcatccgtt tggctttctt 2946481 gaataatatt ccgcacccat tcgttcattt cgtttttcag ccaatgacgg atcggtacag 2946541 ggaaaccaag ctttttgcgg tttaatacgt gctcaggcac aattccttca gcggctttgc 2946601 gaagaagata cttcgtcgtg ccgttcttcg ttttcagctc atcaggaatt tttgaagcga 2946661 cgtcgaatac gactttatcc aagaacggca cacgcagttc caaagaattc gccatcgtca 2946721 ttttatccgc ctttaacaaa atgtcgccgc gcatccaagt gtggatatcg acatactgca 2946781 ttttgttgat atcgctgtac gagctgcttt ctgtaaagta agtcttcgtc acatcgcgat 2946841 atgaaaggtt cggattataa tgcttcaaca gctgcttttt gacagactct tcaaagattt 2946901 tcgcgttacc gatataacga tcctgaagcg gagtgcagcc gcgctcaagc aggctcttcc 2946961 ctctcatacc ttcaggcata acggcagcaa cgtgcagaag catctttttc aagccggacg 2947021 gaatccgttc aaacggttta agcgaaagcg gttcacggta aatgttatat ccgccgaaga 2947081 gctcatccgc tccttcacct gataaagcaa ccgtaacatg tttttttgct tcttttgcaa 2947141 caaagtacaa cggaatcgct gccggatcag caagcgggtc atcaaaatgc catacgatct 2947201 tcggaagctc attcatgtat tcctcaggcg aaatgacttt gctgatattt tcaatgccca 2947261 gcgccgctgc cgtttctttc gctacatcaa cctcactgaa gccctgctgt tcaaagccga 2947321 cagagaatgt ttttaagctt ggatgaaatt ccttcgcaac agacacaata aaggaagaat 2947381 caatcccgcc agacaggaac gaaccgacag gaacgtcact tctcatatga acgtttacag 2947441 agtcatagat cgcgtctcgg acttctttca caagcttgtc ttcttcagtc tgaaccggct 2947501 tgaagttcgc tttgaaatac gttttgaatg tgatatcgcc gtccgggcgg attgtgaatt 2947561 gtgaacccgg ctctactttt ttcacatggg catcaagcgt gcttggttca ggaacaaatt 2947621 ggaaagacat gtactgctgc aatgcctctt tatctatttc aatatcattc tgagcaacca 2947681 ttaaactttt tctctctgag gcaaaataaa cctgatcatt gatcgttgtg tagtacaacg 2947741 gtttaatgcc gaatggatct cttgccccat aaagcacatg atcgttttta ttccaaatca 2947801 gaaaggcaaa cataccgcgc agtttggacg ccgcttcttc tttatagtga cggtaagtcg 2947861 caagaagaac ctctgtgtcc gaatccgtgt tgaatgtgta cccctttgct tcaagttctt 2947921 ctctcagttc gatatagtta tagatttctc cgttaaagat aatccaatat gtttcatctt 2947981 catatgataa aggctgtcca ccattttcta catcaataat gctgagccgt ctgaatccga 2948041 agccgacgtg ctcatcatgg aaatatccat cactgtcagg accgcggtga acgatcattt 2948101 ggttcatttg tttgattagt tcttcttgat cagcggtttg agctaacgga tgcttgttaa 2948161 aaaccccgac aaatccacac atagtattgc ctccataatt aaaattgtca tcattgaacc 2948221 cctatttata gacgctgtga atagtatttg gtttcacagt tatgtaaaaa aataaacatg 2948281 aatacaacga taaaaaaggg aaagccgctt aaccagtaag cggctataaa attattctcc 2948341 taacgcttct ttacgcagct gctccgcttt gtctgtgcgc tcccatggaa ggtcaacatc 2948401 gtgacgtcca aagtggccgt acgcagcagt ttgtttatag atcggacggc gcaaatcaag 2948461 cattttgata atgccggcag gtcgtaaatc aaagttattg cgaacaactt caatcagttt 2948521 ttcctcagaa gcttttcctg aaccgaatgt gttgattgag attgacacag gctgtgcaac 2948581 accgatcgcg taagcaagct gtacttcgca agaatcagca agctcagccg caacgatgtt 2948641 tttcgcaacg tatcttgccg cataagctgc agaacggtct accttcgtcg cgtccttacc 2948701 tgagaacgcg cctccgccgt ggcgtgcata gccgccgtac gtatcaacga tgattttgcg 2948761 tcctgtaagt cccgcatccc cttgagggcc tccgattacg aaacgtcctg tagggttgat 2948821 gaaatatttt gtttcttcat caatcagctc ttcaggaaca accggattga ttacatgttc 2948881 tttaatgttg cgctgaattt gctcaagtgt aatttcaggg tgatgctgag ttgaaataac 2948941 aatcgcgtca atgcggactg gtttgttatt ttcatcgtac tcaaccgtta cctgtgtttt 2949001 gccgtcaggg cgaaggtacg gaagaatatc ttctttacgg acttcactta ggcggcgggc 2949061 taatttatgg gcaagtgaaa ttggaagagg cataagctct ttcgtttcgt tgcacgcata 2949121 accgaacatt aatccttggt cacccgcacc aatcgcttca atttcttcgt cgctcattgt 2949181 gccttcacgg gcttcaagcg cttggtctac gcccatcgcg atatcagcag actgctcatc 2949241 aattgatgtt aaaaccgcac aagtttccgc atcaaatccg tattttgcac gtgtgtatcc 2949301 gatttcttta atggtttggc gaaccgtttt cggaatgtca acatacgtag aagttgtgat 2949361 ctctccgctt acaagaacca aacctgttgt cacagatgtt tcacaagcaa cacgcgcgtt 2949421 agggtctttc tttaaaattt catctaaaat gctgtcagaa atctggtcac agattttatc 2949481 cggatgcccc tccgtaacag attctgatgt aaataaacga cgatttttac tcatgatttg 2949541 cttcctcctg cacaaggcct cccgaaagac cttgtatata tgatacggaa ctcgctccct 2949601 cttatacaat gtacagttat attagagaat gttaattggc atatttatga aataaaaaaa 2949661 ccttttccat cgaggaaagg gtttggtctt tgtgcctttc actcttatcg ctcaaggaat 2949721 catacaacct tgcaacaggt tagcaccttg gttgtctcac tcagttgaac ataataaata 2949781 acagagaaac cggttgctgg gcttcatagg gcctgtccct ccgccagctc gggataagag 2949841 tatccgctca atgaaatatc ttatcgtaaa agggtttgca atgtcaatat gattcagaag 2949901 aaataggcac ctatattgag ggaaaacaat ggaaatgcac acacaaaaaa caataaatag 2949961 tatagactat ttgaaaatat atgttatact aattcacaat tagcaaaaca caaaaaacga 2950021 taaaggaagg tttcatatga actcagttga tttgaccgct gatttacaag ccttattaac 2950081 atgtccaaat gtgcgtcata atttatcagc agcacagcta acagaaaaag tcctctcccg 2950141 aaacgaaggc attttaacat ccacaggtgc tgttcgcgcg acaacaggcg cttacacagg 2950201 acgctcacct aaagataaat tcatcgtgga ggaagaaagc acgaaaaata agatcgattg 2950261 gggcccggtg aatcagccga tttcagaaga agcgtttgag cggctgtaca cgaaagttgt 2950321 cagctattta aaggagcgag atgaactgtt tgttttcgaa ggatttgccg gagcagacga 2950381 gaaatacagg ctgccgatca ctgtcgtaaa tgagttcgca tggcacaatt tatttgcgcg 2950441 gcagctgttt atccgtccgg aaggaaatga taagaaaaca gttgagcagc cgttcaccat 2950501 tctttctgct ccgcatttca aagcggatcc aaaaacagac ggcactcatt ccgaaacgtt 2950561 tattattgtc tctttcgaaa agcggacaat tttaatcggc ggaactgagt atgccggtga 2950621 aatgaagaag tccattttct ccattatgaa tttcctgctg cctgaaagag atattttatc 2950681 tatgcactgc tccgccaatg tcggtgaaaa aggcgatgtc gcccttttct tcggactgtc 2950741 aggaacagga aagaccaccc tgtcggcaga tgctgaccgc aagctgatcg gtgacgatga 2950801 acatggctgg tctgatacag gcgtctttaa tattgaaggc ggatgctacg ctaagtgtat 2950861 tcatttaagc gaggaaaagg agccgcaaat ctttaacgcg atccgcttcg ggtctgttct 2950921 cgaaaatgtc gttgtggatg aagatacacg cgaagccaat tatgatgatt ccttctatac 2950981 tgaaaacacg cgggcagctt acccgattca tatgattaat aacatcgtga ctccaagcat 2951041 ggccggccat ccgtcagcca ttgtattttt gacggctgat gccttcggag tcctgccgcc 2951101 gatcagcaaa ctaacgaagg agcaggcgat gtaccatttt ttgagcggtt acacgagtaa 2951161 gcttgccgga accgaacgtg gtgtcacgtc tcctgaaacg acgttttcta catgcttcgg 2951221 ctcaccgttc ctgccgcttc ctgctcacgt ctatgctgaa atgctcggca aaaagatcga 2951281 tgaacacggc gcagacgttt tcttagtcaa taccggatgg accgggggcg gctacggcac 2951341 aggcgaacga atgaagcttt cttacactag agcaatggtc aaagcagcga ttgaaggcaa 2951401 attagaggat gctgaaatga taactgacga tattttcggc ctgcacattc cggcccatgt 2951461 tcctggcgtt cctgatcata tccttcagcc tgaaaacacg tggaccaaca aggaagaata 2951521 caaagaaaaa gcagtctacc ttgcaaatga attcaaagag aactttaaaa agttcgcaca 2951581 taccgatgcc atcgcccagg caggcggccc tctcgtataa aaaacaaaag ccaagagcaa 2951641 ttatgctctt ggcttgtttt aattgacgga atgcaaagaa gtcagcttgt atgtaatgat 2951701 ggtccggcct tcttcccatt gaagcttctg cacttcagct gtgcctgact tttcgccaaa 2951761 ctttgttttg cgtacatcca ttggaatctc catcggatat actcggtatc cgtccttctc 2951821 taacgtgaat atattttcat ctatgcgaac ttcttttcct tttgtcacaa tcagtgtatt 2951881 aaattcaaca ggcattccca aagtgaaatc ccctttcgtt ctcttttttc tttatcataa 2951941 catatttcac tgtcagcggt ttttcatcca ttgtgtgagc tgccgcacga tacgccggtt 2952001 ttcttttggc gggaaataat gtgtgaatgt actgtagtac catgtttcca ccggcttatg 2952061 cagttgtttt agcttctctt ctaataaata ggaatgctga atcgaaacat tttggtcttt 2952121 ttctccatgg attaacagca cgggagcctg aattttgttt acttggtcaa acggtgtcct 2952181 ccattgatat tcctcaggca cctttttcgg tgttccgccg atgactcttt tcatcattcg 2952241 ccgcaaatcc tgccgctcct cgtatgtaag aatcatatca ctgacgcctc cccaggaaac 2952301 aaatgaagct gcctgcccgc ccatttcgat cgcagtgagc attcccataa ttccgccgcg 2952361 ggaaaaaccg aagatatgga ttctatcctt cttgacattt gggtgctgct gaagcaggcg 2952421 aaaagcagaa aatgcatcct ccctgtcttc tccggcaaaa tcctcattgc cttctcctcc 2952481 ttgattgcct ctgtaaaaag gagcaaacac cacaaaccct tgggatgcaa actggataat 2952541 ccggcccggc cgaaccatgc ccacgctttt aatcccgccg cgcaaatata aaaatccgtc 2952601 atattgtccc ggttccgccg gctcagccag aagcccctta acccgtaatc catttgacag 2952661 atagcagatc gtatacaaac gcacatgctg gcttggcgac ggaaatcttc ttttctctac 2952721 aatcaaaaca gccgcctcct tttttctata tgctttcctt actccaaaat tacatccgga 2952781 gaacctggtt aggcattcac acatttttat acccatcata cgatatgtaa agcaaaaaag 2952841 gatattaact tgatgcgaaa taaggaggtt gtctatgtga acagatggtt aaggctgggc 2952901 ttcgcctgtg tcggcagtat ctttctgatg ttcgccctgg cggcttgcaa gcaggaagaa 2952961 acgctcacca aagtcaaagt agctgaagtg acccattcaa ttttttacgc acctttatat 2953021 gttgctgagt ctaaaggttt ttttaaggaa gaagggcttg atgtcgatgt gaatacgacc 2953081 tggggcggag ataaaacgat gacatcgctt ctttccaacg gctccgacat cgcgcttgtc 2953141 gggtcagaaa catctattta tgtcgaagcg caaggggcta aagatcccgt cattaatttc 2953201 gcccagctga ctcagacaga cggaacgttt cttgtcgcga gagaagatgt tgaacacttc 2953261 gactgggatc agctgaaagg aaaaacgttt ctcggtcagc gaaaaggcgg catgccgcaa 2953321 atggtcggcg agtatgtact gaacaaacat aagattgacc cgcataagga tatagacctc 2953381 atccagaaca tagacttcgc caatattgcc aatgcgtttg cttctggaac cggtgagtat 2953441 gtacagctct ttgaaccgca ggcttctctc tttgagaaaa aaggcatcgg ccatatcgtg 2953501 gcttcattcg gagaagaatc aggagaggtt ccttatacga cttttatggc gaaacaaagc 2953561 tatttgaaga aaaatgaaga cacagccgtc aagtttacaa aagccattta taaggcgcag 2953621 cagtgggttg aaaatcattc tgcgaaggac atcacagatg ccattaaaga tgaatttgat 2953681 gataccgacc cagacgtcat cgaaacatcc attgaacgct ataaaaaaca gcattcatat 2953741 tcaccagacc ctctgcttaa cgaaaaagaa tgggagcttc tccaaaccat tatggataaa 2953801 tcgggagaac tgccgaagca cattccatac aatcagcttg taaataaaga aattgctgaa 2953861 aaagtcacct cggagaaata ggaggcgcca tctatgtctt tcttacatgt cgaccatgta 2953921 acccatactt atttttctat taaagaaaaa acaacggctg tgcgggatat tcatttcgat 2953981 gccgaaaaag gcgatttcat ctcatttctc ggcccaagcg gctgcggaaa aacaacattg 2954041 ctttccatta ttgccggttt gattgagcca tcagaaggca gagttctgat tgaaggccgt 2954101 gagccgaatc aaaaagaaca taatattggc tatatgcttc agcaggatta cttatttccc 2954161 tggaaatcta tcgaggaaaa tgtgcttctc ggtttaaaaa tcgccgacac gctgacagaa 2954221 gaaagcaaag ccgctgcact cggtctattg ccggagttcg gcctcataga tgtggagaaa 2954281 aaatatccga aagaactgtc aggcgggatg cgccagcggg ctgcgcttgc aagaacactt 2954341 gcgcctaacc ctagtctgct tttgctggat gagccatttt ccgcgcttga ttttcagaca 2954401 aagctgtctt tggaaaacct ggtattccgc acattaaagg aatatcaaaa aacagcagtg 2954461 cttgtcactc atgatatagg ggaagcgata gcgatgagcg atacgatctt tttattttca 2954521 aatcagccgg gcaccatcca tcagattttt accattccta aggaattggc cgcgatgttg 2954581 ccttttgacg cccgtcagga accttccttc cagacactgt ttcaaacgat atggaaggag 2954641 ctgaattctc ttgagaaaca gcaaagaaac cattgatctg cttcacgagc agtatcaatt 2954701 caaacagaaa aaggaaaagt ggaaggtcca ttcctttcag cttgccatat ttattctctt 2954761 tttctcgggc tgggaaatct ccagcaggca gggctggatc gatccgctga tcttcagctc 2954821 tccatcagct gtgtggcgat tattgctgga gaaacttggt gacggttctt tactgtcaca 2954881 catcggcgtc actttatttg aaacggtgct tggctttttg ctcgggacgt ttatgggcac 2954941 gtgcctagcc gctttgttat ggtggtctaa ccgacttgcc agaattttag atccgtatct 2955001 tgtgattttg aacgcaatgc cgaaagtggc cctgggcccg atcctgattg tcgcgctcgg 2955061 tcccagtttt atcagcatca ttgcgatggg agccatcatc agcgtcatta tcacaaccat 2955121 cgttgtctac accgccttcc aagaggtcga cgaaaactat acgaaagtca tgaaaacatt 2955181 cggcgcaaaa aagtgggtta tttttaaaga agtcatactg cctgcatcct cccccgcgat 2955241 tatttcaaca ctaaaagtga acgtcggttt atcatgggtt ggcgttattg taggggaatt 2955301 cctcgtttcg aaggtcggat taggatatat gattatttac ggattccaag tcttcaattt 2955361 tacactcgtc ttcttaagcc tgctgatcat cgccatcttc gccactctga tgtatcaggg 2955421 cgtcgagctg ctggaaaaga aatggacgaa ggggaggaca taaaaaaccc ggcacatgtg 2955481 ccgggttttt tattcaatcc atccagattc tttcagtttt ttcaagctga tcggaagaac 2955541 ggaatccttc ataataaagc tgaatttttt attgcgggaa aggttctccg gcagctcgtg 2955601 aaacaaaacc gggcctttcg tttcaaagta atcagcctgc ttttcaagct tttctatatc 2955661 tgcaaaatat atatttttta caatcacttt ttcttttccg agaactttat actgtccgag 2955721 atacttgagg cttttgactc tcgcgcccgt ctcttccttt acttcccgga gcgcagcctc 2955781 ttctgcgcac tccatcggct ctactttccc gcctggaaac tcatagcctc tgtcctcatg 2955841 ttctgttaaa agccatttgc cgccaaaacg gcaaatcacc cagacatgct tcgggctgtc 2955901 cgagaaaggc tgatcgtcaa aggaaagctg aacagtattc tgataataat ctttaaactc 2955961 gtacatgttt atccctcaaa tccgttccta gctatcttcc atacatcata ccacagttac 2956021 gtttcttcgg aagcctttta tcaaaaaata agggaaaccc agcacgccgt caggttctgc 2956081 atgcagacta gctcgtacag tttttttgcg atacttttgc cggaaagtgc gaccgacgct 2956141 ctgggcttta ttatgacccg cgaacaggga aaagttacgg tttgcgctta aatttatttt 2956201 ttaacgtttc taaaagatcg acaagcatct gaggaaccgg tatgccaaga gagctggctg 2956261 tcacaacaat ttgcacagat tcataaagaa tataaaacat aatagccaag tcacgaattg 2956321 atccctgtgt attcagcagc tgatcaaaaa agtggcatac agagatcaga gccagcgtga 2956381 ctaatttttt gacaagccgg gcaaatacct ttttaaatga cagtttgtga ataatggttt 2956441 ccttcaaagt cgtactgata aattcaattg ccataagaga gagcaaaatc agaaatgaat 2956501 actgaaaacc tccaaagaaa aaacccgctg ctgaaacgct gactgctaaa aacgaaaaga 2956561 tgccaaagtc tctatccatt tatcccaaca tcctttcaca gaaacggcct tacgatattc 2956621 tatggtaaac aagccgaacg gattggattt ttcagaaaaa tggactggtt gtcgcctatt 2956681 tttcagatac aaaaagaaaa gccggacgtc ttttttaaga catccggccg ttctattttt 2956741 gaacttaacc taggtaagct tttagcatcc agttatgttt ttcaatattt tgatggatcg 2956801 caagaagcat gtcccctgtt gtttcgtcac cgacttcatc agctaaatcc atgccgtttt 2956861 tcagctcttc cgcgatgact gtgaaatcat catatacgct ttgaaccatt tgttcagctg 2956921 tttcatttcc agcagcttct ttgacagaag ccgtttctaa ggattccttc attgttgcaa 2956981 tcggttttcc gttcagcgcc aaaagacgtt ctgctaagtc atcaatataa gttgctgttt 2957041 cgttgtacag ctcctcaaac ttttcatgaa gagtgaagaa atctttccct ttcacatacc 2957101 agtgataatt atgtagtttc acatacatga ccgtccagtt ggctacttgt ttgttcactg 2957161 cttgaatcaa ttgttctgac atggtatctc ctccttgtta tatgactatg tataccctta 2957221 atatcgtacg ctaaaacctc ttttttaccc ttatctgtca cgatttcttc tattatgcta 2957281 caattgttaa aaaacgggag gtggaatgtc atgacgcttc tcattacgat aagtattttg 2957341 attgtgctgg ctgttttgct tgtaaccatt tggacgactg taaaagccta taatgtaaag 2957401 cataccattg atccaccaca agaaaatcac tctgattcac acaatcaatg atgatgtgaa 2957461 tgctcctctt ctgactgatt gctggcagca tcggcgtctc cgacttggac ttttaaggtc 2957521 ggcatgctat gctgtttttt tgctgtgaca tgagattgga cagtgtatac accatcttcc 2957581 ttaaacgtcg tttccaatcg gtatacgcct ttttcttgtt tcaccttaaa catttggctt 2957641 gcgtcttttt ccccttcttt ccatacttca aactctactt catcggcatc cgtcacagct 2957701 tcatcaccat atgatacagc tgcttcataa gcagcgcttt ctccgggatt tactttttca 2957761 ggcccggtca gcttgacatc caaaacctcg ggcgtctcag ctgtatttgc tttactttca 2957821 ccagatccgc atccattaag caataaagca gaaaaaagca gaacaaccaa catctttttc 2957881 atgccatcac cctttcatcg tttacctaaa tagtagcaaa cgcttacagc aaatggtaca 2957941 caaaatatga gacgtcacaa aaaagacctt tttgcttaag cgcaaaaagg tcctttctat 2958001 tttagccaaa tacttttagc aattcttctt tatcctgtga aagccagaaa cgcattaaac 2958061 gtttagcgcc ttccagatca tgaagcttcg cttggccgca ctgcttttca ttcgcagcag 2958121 gtatttctgt aatctctacc gcttccttca ttgtgtcttc aagcagatca acgatttccg 2958181 ctgatgtcgg ctctccgctc acaactagat aatagcctgt ctggcagccc attggagaaa 2958241 tatcaatgat atcaaaatga tcgtatttct cagcgtgaga acgaatcgta aacgcgagca 2958301 aatgctcgag tgtgtgaatg gtgtcaggct tcatcgcctg tttatttggc tggcaaaaac 2958361 gaatgtcaaa tttatttaca acgccgtctg ttcccacttt atgcacgccg caatgtctta 2958421 catatggagc aacaaccgca ttatgatcaa gctcaaaact ttctactgaa ggcataatgg 2958481 cactctcccc ttttttaaaa atgtaatttc attataacat acttttccga taagaattat 2958541 tgattaactt ttcaatctgt gttttttttc ttatacttgc atcagaaagg ttgctgaaga 2958601 aacatgaaaa ccctattcat cgctctgatc agaggatatc aaaaattcat ctcgcccctg 2958661 acaccgccaa cgtgccgctt ttatccgacc tgttcccaat atggaatcga agcgattaaa 2958721 acacatggcg ctttaaaagg cggatggctg acaatcaaac ggattttgaa atgccacccg 2958781 ttccatccgg gaggagtcga tcccgttcct gaaaagaaac aaaaacatta attgttataa 2958841 ccgtttacga taagatccag ttttccggtt ttaggatcaa tgactaagcc atggaccgga 2958901 acgttttcag ggaacagcgg gtgatgttta ataacatcta cgctgtcttt cacactcgct 2958961 tccactgaat caaagctttt aaaccattga tcaaagtcta caccggagta ctttattgtt 2959021 tcgatgcgtt cttccggaat ccctcttgct ttgatttttt caagcatgct tttgctgctg 2959081 attttgctca tgccgcaatc gtgatgcccg atcacacaca cctcatctgc attcagctcg 2959141 tacactgcga cgagtatact tctcatgatg cttccgaatg ggtgtgtcac aagcgcaccg 2959201 gcacttttaa tgattttcac atcaccgttt cgcaaattca tcgcatgcgg cagcagttca 2959261 accagacgag tatccatgca agaaagaatc gccatttttt tatctggaaa ttttgatgtt 2959321 tgatactttt catactctct ttgttcagta aatgtcttgt taaattcgag aatatcattt 2959381 agaagactca tgttcgttgt ccctttctat tctttttact cttcaatata tcacaaccct 2959441 tgtttattcg tcataataaa aaaagacaaa ccctcaggcc tgccttattt ccccatgtta 2959501 tagcgttttt tgaactgctc aactcgtccg cctttttcat tgaatttctg gcggcctgta 2959561 taaaacggat gcgtgtcaga gcttacctct actttaatga caggatatgt gtttccgtcc 2959621 tcccactctg ctgtttcatt agatgttttc gtagaggtgc ttagaaaacg gtagccgctg 2959681 ttgacatcct gaaatatcac tttgtggttc tttggatgaa ttccttcttt catgggtatc 2959741 tcctttcaat aaatcgtaat aattacgttt tattttataa ccttacaaac gttttgtcaa 2959801 tcttcttata tccttccctc tgtttcacat cgtaaacctc atggcattta agaataggaa 2959861 gaataatcta accgaggaag caaataataa acccaaaata catacagaac gtctttttgg 2959921 aaaggtggtt tacgattgtg gatgatttag ttttggccag aagccttttt ggcacgacga 2959981 tgggctttca tatcattttc gcaacacttg gagtcggtct gccgctcatg attttagtgg 2960041 cggaattgat ctatcaaaaa acgaaagatg accattatgc gatcatggcg aaaagatgga 2960101 cgaaagcaca agccgttttg ctgggggtcg ccataccgac cggaacgatc gcgggcactc 2960161 agctcgcgct tttatggccg ggatttatgg aagtcatcgg ccgggtgatg tccctgccat 2960221 ttcaaattga aatctatgct ttttttgttg aagccctatt catgtcgatt tatgtatacg 2960281 ctgcagaccg tttgtcacct gcaatgagga ttgttgctgt tttctttgtg ttagtcgggg 2960341 cagcagcatc cgctgttctg atcacgaatg ttcacgcttt tgaaggtacg cccgccggtt 2960401 ttaaaatttt aaacggaaaa attacagatg ttgacccgtg ggctgcgttt tttaatccta 2960461 gcttttttat cactgccggc catgtcgtgc tgtccgcgtt tatgactggt gcgtttatcg 2960521 tggcttctgt tgcggcgtat aaaatgatcc gaacgaggaa aaaggaaagg gtctatcgct 2960581 ttcaccggaa agcccttttg ctcgcactga cgatcggcgg tattttttca ttgctgaccg 2960641 ctttgaacgg acacgaatct gcacagatgc tgtacgaata ccagcccgaa aaattagccg 2960701 gtgcggaagg cctatttgaa acaagatccc acgccccgct cgctatcggc ggttttaccg 2960761 acccgaatga agaaaaagta aaatgggcaa tcgagattcc atgggcttta agctttttgg 2960821 cagcgaaccg ttttgacact gttgtaaaag gattaaatgc atttccgaga gatgaatggc 2960881 cgccgctttt cattcacacg ctgtttaatg cgatggttgg tgtaggcatg ctgctaattc 2960941 tttattccat tatcggtgtg gtctggagaa aggtgctcaa gaaagaccgt ttcccaacgt 2961001 ggcttttgat cattttcatg acagcaggcc cttttagtct catcggcatt gaattcggct 2961061 ggattttcgc atgtacgggg aggcagcctt gggtcatcta tcatctgctg aaaacgtcag 2961121 atgtcgtaac aacgactggc tcgatcgggg tgctgttctt atttttcaca tttgtttatg 2961181 ccgtgttagg cgcagctgtc gtctacgtgc tgctgtatta tttccgcaag cacccggttg 2961241 acgaagattt aaatacagcg gagtcgtaat ggctccgcaa acaggaaacc aaatggaagg 2961301 aagatcgtac aaatggagat ttcaactgac gctctgatcg ccatctcaat tatctggggc 2961361 tttgtgttta tttacgccgt catggcgaca atggattttg gagcgggatt ttggtctatg 2961421 atctatttaa acaaggagca tatgaaggcc accgatattg cgaatcgctt tttgtccccg 2961481 acttgggagg tcacaaacgt ctttattgtg gccatcgtcg tggcgctttt cagttttttc 2961541 cccggcgcga catttgtgct cggcaccgtt ttattaattc ccggaagcat gattttgctg 2961601 cttttagcaa ttcgaagcgg atttctcgtg ttttcaaata cagcaaagga gcggaaaacg 2961661 ctaagatata tttccggcat ctccggcttt atcattcctg ctattttaat tttggtgctt 2961721 cctgtgacac acggagggtt tatagaaaaa acggatggaa tctataactt aaatatgtct 2961781 aaaatctttt caagccccaa cgcctattca tttatcgggt ttgcgatttt aagcacctta 2961841 tttttgtcct cgctgttgct tgcagatttt tcaaatgtgg cagaggaaca ggatgcgtac 2961901 cgagcctaca gaaaaagcgc cctgattacc ggcccgattt cactgttgtt tgctgtatgc 2961961 attatggtaa ctatgcggaa tgaagcaaac tggctgtaca gcggaatgat gaatgatttt 2962021 tcttggatta ttgcatcgtt cattacattt gtcattgctg gaatcgctct ttttctgcct 2962081 aacaaaagct ttggtcaaaa catcggaaaa ccgcgtctcg cacttgttgc gattgggata 2962141 cagtattttc tcgcaagcta cgcgtacggg cgggcgcatc ttccgtatat gatttatccc 2962201 gatgtgacag tcatgtcagg cttcacagag ccagcaacgt tcagagcgct gtttgcaacg 2962261 tatatcgttg catttatcat tctatttccg ggcttctttt tcttctggaa aatgtttatg 2962321 cgagataaac gctatatccg ccaggaggaa tagagggcaa gccagccggc tatactaatc 2962381 cagaaccttt ataaggaggg gatggcatgg agcagaaaat tctatgtgag gtcaacaact 2962441 gttcttattg gggcaaaggt aacaaatgca ccgctgatgc catttatgtt gtcagccata 2962501 ctggtgaaac ggctgaaaac agccgggaaa cagactgcaa aacgtttaag ccgcatgatt 2962561 tataattaaa agaaagagct gcatcagcca gctctttctt tttgcatgtt gagtgttctc 2962621 agctttttag ttatgacccc gtttgcaggt gaaaacaaaa aggcgcttgc ataacataca 2962681 cctgtcatgg ccgccatcgc tcctgaaatc gaaacattaa gccacgttgc gaagaaatag 2962741 cccatgaccg ccgacagccc gccaatcaac gcgctgagaa tcagcatata aagaagccgg 2962801 tctgtcagca aatgtgccgc agccggcgga acaatcagca tggccacaac caatacggca 2962861 cccaccgaat caaaggaagc aacagtcgtc aaggacagca tgcccatttg cacgtaatga 2962921 atgagcaaaa ccggtattcc caaggctaaa gccatttgag gatcaaacga agcgatttta 2962981 aactccttat agcacacact gatcaacact acgtttaaaa ccagaacaga tgccagcatc 2963041 caaaacgctt tcggcccaat atcaaccccg aataccgtca ccgtattcca cggcacaaaa 2963101 gcgatttctc ccattaacga gtgctcaata tcgagatgga cattcgctcc atacacagaa 2963161 agcaaaataa ccccgattgc aaataaggat gtaaacacaa ctcctatggc agcatctgat 2963221 tgaaccccct tgctatgaag aagctgaacc aagaaagccg ttaacagacc ggttgcggct 2963281 gcgccaataa acatataaat cccatcgaga cttcccgtca ctagaaaagc gccgacaatg 2963341 ccaagcaaca ctgtgtgact gattgcgtcg gccagcatcg ccatgcttct cagcacaaga 2963401 aatgtgccga tcaatccgca gcttacaccg actaatacac cggtagctat aatccatgct 2963461 tcaaaactca tttgcgatct gtcccttctc ggcatcatga gacgcttttc gacgctcagg 2963521 catccgtcca tacagcttta agagtgaata aagccgctct ctcgtttctc tcggtaaacg 2963581 gtccgggtca aagtagtcct gatcggattc tatattggca agttccattt catgcatgag 2963641 atacacttca tacatccgct gcttcaaagc tgtgtgatag cctttttcta tccctttgct 2963701 tgtgatttgc caaatcccat tttcgatacg ctcaatgcac ctctcttgtt ccaagtcatt 2963761 taatgcctta aggcataatg aaggggatag gcgtcttttc tttcttacac tttcaacagt 2963821 tacacaaaga ttattctttt catactgttc ataaatcgcc aaaagcactt gctccctgct 2963881 tgttctgcgc cgcagcctca tcagccttat ggctttagca gccaatcccc gcttaggcgc 2963941 gcaaatcatt gaaaaaagaa agagcagcgt tgcagataag atcattaatg gccctgtcgc 2964001 cattcccttc atcgtggtgc taagcagggt tccggccact ccgctgaccc cgcctgtaat 2964061 cccggcaatg atgatcatcc cggttaatcg ttcggtccaa tatctcgcgg ttatggcagg 2964121 tgtaatcagc atagccgcca ttaatatcac accaacagtc tgaagcccaa tgacgacagc 2964181 acagacaatc agacaagcca aaagcccgtt taaaaaacgc accgggattc ctaatccctt 2964241 tgcaaacgcg agatcaaaag taatcaatgt aaattcctta aagaaaacaa tacataggag 2964301 cagtagaaca gcggatatcc ctgcaataag gatgatatcc tgcctgacca atgaagcagc 2964361 ctggccgaat aaaaaagaat caagcccgct ttggcttccc gccccctgtt gctgaatata 2964421 tgtcagcaga atgatcccga cgccaaaaaa cacagaaaga acaatcccga tcgccgagtc 2964481 ctcctttgtt tttgaaagcc gaggaatcag ctgaatacaa aacgttccga gcagtccggc 2964541 gagcgctgcc cccagcaaaa agaaaggcag tgatttttgc ccggtgaaca gaaaagcgag 2964601 acacactccc ggcagagctg aatgggccat cgcatcgccg attaaacttt gctttctcag 2964661 cagcacaaag ctgcccaaaa caccgcttgc cgtcccgagc aaaagcgtac cggccagcac 2964721 ccactgtgta ttcggatgct gaagctgcag ccacaaactt tcaaacattg cgctcactcc 2964781 ttatgtcctt ctgccagcac tttatctttt aaaaacgtaa gccttcctcc atatgttttt 2964841 tgcaggtttt cgatcgtaaa aacgttttcc gtcggtccga aagcgatttt ccttaaatga 2964901 agcagtaaga tccaatcgaa ataatcctcg gcggtctgca gatcatgatg gacgacaagc 2964961 acggtttttc ctttttcttt gagttctgcc aacagcgtca taatcgcgcg ctccgtcgct 2965021 gcatcaacac ctgcaaacgg ttcatccata aaataaatgt cagcgttctg gcagagtgcc 2965081 cgggcaagaa acacccgctg ctgctgtccg cctgacagct ggctgatttg ccttttcgca 2965141 taatcatgca tcccgacttt tgttaatgcg gccttcgcca tctccacatc cgctttcttt 2965201 ggcctcttta ataaaccgat tctcccgtat cttcccatta ggacgacatc gagcgggctt 2965261 gtggggaaat cccagtcaac cgagccgcgc tgcggaacat atccgattct ggtccgctga 2965321 tccttatagt ctttgccgta aatagagatg tctccggaag ctctgggcac aagaccgaga 2965381 atcgttttga tcaaggttga ttttcccgcg ccgtttgggc cgataatgcc aataagtttt 2965441 ccttcaggca cctgcagcga aatgtcctgc agtacaggct ttttatgata agcaaccgtc 2965501 acattatcaa gctcaacagg gaacatatcc tccacctctt ttctttattt aagcgcttta 2965561 gtaatcgtgt tgatattgtg gcggaacatt ccttcgtatg tgccttcttt tgtgcccttt 2965621 tcacccatgg catccgaata aagctgaccg ccgattgtga ctgtatggcc tttttcttta 2965681 gcgccttcca ccactgcatt gattgatttt tcagatacac tgctttctac gaacacagct 2965741 tttatttgtt tttctgtcag aagatcaacc agctcctgaa catcccttaa tccatagtcc 2965801 gaatctgtgc tgagtccctg caggcctttt accttaaatc catactcatt cccaaagtac 2965861 gcaaacgcat catgagcagt cacaagcaca cggcttttct ccggaatatg tgcgatctcc 2965921 ttacgcgacc acttatctaa atattgcaaa tcttctttgt actctttggc atttttccga 2965981 aaggcatctg cgtgctgagg cattgctttg ctgaattgcg cttcaatttc atccaccgca 2966041 tagatccata acggaatgct gaaccagacg tggggatcaa acgtcttgcc ttcccccgcg 2966101 ggaataagct tatttttcgg aatggcctca gctactgccg ccgattgttt ttgttcgccg 2966161 attttttgga ggacatcctc cattttccct tccaaatgca acccgctgta cagaacaaca 2966221 tcggcagaca ttaatttttt cgtgtcacct tgggaagctt tgtaaaggtg cggatcaacc 2966281 cccggtccca ttaaagaggt gacttttacg tgcttacctc cgatgttttc tgctgcatcg 2966341 gcaatttgag atgttgtcgc tgtcacttgt aattgctgat cagcgctttt tccggctgaa 2966401 tccgttccgc atcccgttaa agcaaaggtc gcaaaaagta ctgctgccat cagcccttgt 2966461 ctcatatttc tcctcctctt tgccatcaat gtccgattgt tttatcttat gttgtcagtt 2966521 cttagacatg tgacattaaa ttagccaaaa gcatgtttta tttacacagg acaaaaagtt 2966581 tccctcatgc aaaattatcg cgtttggcca tttttgtcaa gctgatttac ataaaaaaac 2966641 cggctgggtc agcagccggt ccaaacgaga agggatgtat tcaacgaaca cttttactgt 2966701 aacagcacag tgtcatttat tcaaaatagc aaaatgcttt tttcttaacc atgctgtgtg 2966761 aaaacatcca ttttggtcac atattttcgc ataatatctt ggtttacctc aacccctaaa 2966821 ccaggctgtt ttgacacaga aataaatcca ttatcaatac gaatatcagg agttacaata 2966881 tcttcatccc aatagcgtga ggatgaagat atatcgccag gtattgtgaa ttgaggcagt 2966941 gaagcaagcg ccacgttctg cgctcttgat atgcctgttt ccagcattcc tccgcaccaa 2967001 acctgcatat gatgctcttt gcataaatca tgaattttta aggcttctgt taagccgccg 2967061 acacgagaag gttttatatt aataattttg cagcttccta gctcaatcgc ccgtctcgca 2967121 tcatcaactg aacaaatgct ctcatcaagg caaatggccg ttttcaaatg tttctgcaag 2967181 tggcggtggt caacgatatc gtcagcttgg agcggctgct caatcatcat taaatgatag 2967241 tcatcaagct cctttaaacg gctgatatcc ttcagttcgt aagaggaatt ggcatcggcc 2967301 ataagcggga tggttgggaa tcggctgcgg atggccttga ccaattccac atcctgccca 2967361 ggctgaattt taatttttat tctttgataa ccttcttttt gatagctctc aatttccttc 2967421 agcatatcgt caagaggcgc caggccgact accaccccgg cagggacttt atctcttgtt 2967481 ccgcccaatg cctcagcaag ggatacgccc ttctttttgg cataaatatc ccatacagcc 2967541 gattcaagtc ccgcttttgc catccggttt cctttatacc gcgccaggct gtccggcact 2967601 tctgaagggt gattgaattc acggccgacg acatttggga taaaaaaatc ttttagcata 2967661 tgcaaacatg ttccaatggt ttcctcggtg taccaaggcg aagagaaagc ggaaacttct 2967721 ccccagcctg tgacacctga tgtatcaatg gcttccacga tcagaaattt acgctcttga 2967781 agcgtttcga tactgttttt aaacggtttc tttaagttca tgctcaaatg gtaaagcgtg 2967841 attttttcta tttcgatcat agcagttctc ctttacgcgc atccttcagc tgatttcgca 2967901 agagcttatt agacgcattg cgcggcaggc ggtcaagcac aaagaatttt gccggaattt 2967961 tatacttcgc caagcgttct ttgcagtagt cagtcaattc tcctgcgctc acaggcttgt 2968021 gaaggacaag ataggcgtga ggcactttcc cccatttttt gtcctcagcc cctgaaaccc 2968081 cggcttcggc cacagcgggg tgtgaaagca gcactgactc cacttcggcc ggataaatgt 2968141 tttctccgcc ggatatgatc agatctgaac gtctgtctaa tacatataaa aagccttcat 2968201 tgtccaaata accaagatca cctgttttca gccagccatt ttgaaaggag gcttcgtttg 2968261 cgctctcccg gttaaaatag cttttcatga cattcgggcc tttgaccatg atttcaccgt 2968321 gttcatacgg ttcacatacc tgtccgtccc gctctatttt gatttcacac gaaaacagcg 2968381 gtttccccgc agatccgagc ttttccatgc tgaattccgg cgacagggta acaatttgcg 2968441 agcatgtttc tgtcattcca tatgactgaa agacagggaa tcctttctca cggcattcct 2968501 caagcaatgg cagcggtgca ggaccgccgc cgagaagaat gcatctgatg gattcagggc 2968561 agcggtttgt ttcttccaaa agactggcca gcatagtctg caccgcagat atcattgtca 2968621 cttcatgcct gttgatagaa tgcagcacat cgcttacgga aaaacgctgg tgaagcacga 2968681 cagtcattcc atagatcaca gatttaaata atgcggacaa tccgctgata tgaaagagcg 2968741 gcaatgcgat aagccagcgg tcttgttctg ttatacccaa attaagagcg gacgacaccg 2968801 cactgaaata atggtttccg aacgtttgct gaactccctt gggctttcct gtcgtacccg 2968861 acgtatacat cagcgttgcc gttgcatcca tttgcatata agcctcgatc tcaatttcct 2968921 ctgctgcttc tttcatcagt tcatccacat caatcgtttg aacgatgtgt tcatattctt 2968981 tcttctcaaa gcttgaatct gtcaataaaa agccggatcc cgaatcctcc agctgaaaca 2969041 gcctttcatg tgttgacagc ttcgtattca aaagcaccgc cttaacacca agcaaaaaac 2969101 aagcgtgaac agcgtatacc atttctgcac ggttttggag caaaatagct gcagtatccc 2969161 ctttccgaac cgaatgagcg gcaagctgtt ccgccattcg tttagacgcg gcaaacaatt 2969221 ctgcaaatgt cacggtttgg tcttcataga tgagagcgat tctctcaggt gtcagctgtg 2969281 cccgctgcat gagccagttg ggctgttctg tcagcatgtc atcatctccg aggtaaaatg 2969341 tctgtattga aaagaaaaca gcttggaccg caaagtctca agctgttggt ttactagata 2969401 ttgctgatca cggaaaacga gggaactgtc cgaaatcagg tttgcgtttt tccttaaagg 2969461 aatcacggcc ttcttttgct tcatctgttg tgtagtaaag aagggtagca tcccctgcaa 2969521 actgctgaat tccagcaagt ccgtctgtgt ccgcgttaaa cgcagcttta agaaagcgca 2969581 gtgcggtcgg gcttttttca agcatttctt cacaccattt aatcgtttct tcttcaagct 2969641 gttccaaagg aacgactgtg ttgacaagac ccatgtccag tgcttcctgt gcgttgtact 2969701 gacggcatag gtaccagatt tcacgtgctt ttttatgtcc tacaattcga gccaggtagc 2969761 cagaaccgta acctgcatcg aagcttccca ctttagggcc tgtttgtcca aaaattgcgt 2969821 tgtccgcagc aattgtcaag tcacatacga tgtgaagcac atggcctccg ccgatcgcat 2969881 atccggacac catcgcaaca accggtttcg ggatgacgcg gattaaacgc tgaagatcca 2969941 atacgttaag acgagggatc tggtcgtctc ctacatatcc accgtggccg cgcacttttt 2970001 ggtctccgcc agaacaaaat gctttgtccc ctgcaccggc aagcacgata accccaacgt 2970061 tttggtcgtc tcttgcgtca gcaaacgcat caatcatttc agcaaccgtt ttaggggtaa 2970121 acgcattatg tacctcaggt cggttgattg ttatttttgc aatgccatta tacgtttcat 2970181 acaatatctc atcgtatgtc cgttttgttt tccattcagc catatgatga cctcctttta 2970241 ttctctatgt gaatgagtca gatgcttgtc aaaaactcac tcactatttt accaaacaat 2970301 cgcggctgct ccacatggac cgtatgtcct gcttttggaa caatctctat tctactagaa 2970361 ggaagcatct tatgcacctc ttgattgatg gcgcaaaatt tttcgtccca ctccccgcag 2970421 atcagaagca caggaacatc tatttcctct acacggctcc acaaggaagg ctgtgaaccg 2970481 gtgcccatgc cggttaaact gttcgcaagc ccaatcttat tgttccgcag acggcccgat 2970541 cgtatcctgt accgaatatc ttcagccagc ctctgctgag atgaaaacaa agggatattc 2970601 tcccaatacg caacaaacgc ttcgagcccg tctcgtaaaa taaaatcagc aagcttccgg 2970661 tcccgcatga ttcgttcccg ccgttcccca agtgttttga gccccggcgt cgtgctttca 2970721 agcacaagtg ccgatacccg ctcgggatat gtcatcgcaa aagagtaagc aagccttcct 2970781 cccatagaat acccaatcaa tttcactttg tgaagtttta attgatcaaa aatctcggca 2970841 aggtcagaaa cttgccgggt tgtgctgtat cttttcccat tcagcggggc atcggtttcc 2970901 ccatgcccta aacaatcaat tttgatcaaa cgggaatcag gcagcatttc atcaagaaaa 2970961 gtccatgatt gtttgctgcc ggtaaaccca tgcagacaga cgacggcttc ggaagcattc 2971021 ggtccctcgt ctgccactgc atatcggaca ccatctgata ccgttatgtt tacagttccc 2971081 attgtttttt cacttcccgc acagcctcat tcagcatatc gcgatgaagc tggactcttg 2971141 attggcgatc cgttttgatt tcaatcaaat ggagtccggg cttgtctgcc tgcggcgcgt 2971201 aagctgtttt gaattcatcc caagaagccg ggcatgaata cgttccgccg taaagtgcag 2971261 ccgcatgctt gaaatcgagc cctgtcggtg tgccgaacaa atcttcaaag tgtgtcttct 2971321 cagaagcctg cggcaaaaag gagaaaatcc ctcctccgtc attattgaca agaatcacag 2971381 taagaggaat acccagcttt ttggccgcca gcaggccgtt taaatcatga taaaaagata 2971441 aatctccaat cacaagggta acaggcgctt ttgttccttc acataccccc atggcagagg 2971501 agacgacacc gtctatcccg tttgctcccc ggtttgaata aatccggaaa gggcggtcct 2971561 gcttttcaaa aaacgtatca acatccctga tcggcatgct gtttcccaca aacagcgagc 2971621 tgttttcagg cacaagatgc tgaaggattc gatagagatt gccttcaaac gaaacatctt 2971681 cactgctgat tgtttgcaga tgctcgcgga accgcccatt gacaaactgc cacttttcca 2971741 gccactctga ggatctggtg gcagcagtaa ggcctgccat gatctcctca gcaaaaacag 2971801 acgcattaca atgaatcata tgcgcgcttg cctgtgtcgg gtctctccac cctccatcct 2971861 cgtcaatcac gatttgctga atcgtcggat catccttaag ccataagaaa accggttttg 2971921 aaacaggcat cggtccaaac cgaatgacaa catcaggacg gagtttccgc ttcagctcat 2971981 catcttttaa aaacgaatca tacgcatcaa taacagtgct tttatcatga acaccattcc 2972041 gcagattaga cagcggatct gctaaaattg gatactgaag cgcttttgac agcgcaataa 2972101 tgttttcctt gtccgcatca ctatggagct ctccgcagac gatcattcct ttttcagcct 2972161 ctgcgagcat ctcagccaca tcagacaggg actctcggtc aacagactgc gtacccgttt 2972221 tcacagacac atgacggcct gttctcattc ttccaaacgg ctcatctgaa agatccggca 2972281 tcagcggttc gcgcagcggc acattcacat ggacaggccc catcgggcgc ttttgtgctt 2972341 ctccggcagc gcggcttgcc agcgttcgga tgtatctcag catttgcgga gactcttcag 2972401 gaagagcaga gtctgtgaaa aacttaacaa agttaccgaa taagaagtgc tgattaatag 2972461 cctgcggtgc gcctacttcg cgcagctcat gaggccgatc agcagttaac acaataatag 2972521 gcacccttga ataatgggct tcaaccacag ccggataaaa gttggccgcg gctgttccag 2972581 atgtacagat caatagtacg ggacgctgct tcgcttttgc caaacctaat gcaaaaaatc 2972641 cggcagacct ttcatcaatt tggacatgga cgctgatatc gggatgcgca gcacaaagaa 2972701 cagccagcgg tgtagatctt gagcccggac aaacgacggc gtccgtaatt ccggaaaggg 2972761 cgaattcatc aataaaactt ccgatgtaat gagtaatcgg gttgactgtc aacgcctctc 2972821 acctcctaat gcagagatca tcggcttcaa tttaatctgt gtttcttcat attccgagat 2972881 tggttccgag tcttccacaa taccgcaccc ggcaaacagc cttgctgtgc ttccttcgat 2972941 gagccctgaa cgaatggcga ccgcgaattc cccgttatcc tggctgtcaa tccagccgat 2973001 aggggccgca taccagccgc gggacatcgg ttcaatctcc ctgatcacgt caacagcttt 2973061 ttcctgaggt gatcccccaa gcgcgggagt ggggtgcagc ttctcaatta agtcaaaaat 2973121 cgaagcagac tcgcgcagct gtccgacaat cggcgtaaac aggtgctgaa cgctttttgt 2973181 tttgtacaaa acaggtccat caggcttttc aacctctgaa cagcttgata caaaagcatt 2973241 atgaatcata cctaccacaa tatcatgctc aagcaggttt ttctcatcgt ttaataattc 2973301 aaggcctatc cggcggtcgt cttcttcatt cacgcctcgt ttaatggagc ctgccagaca 2973361 ggaagacatg acagtgccgc cgtctctttt gatcagtctt tccggagacg cgccgacaaa 2973421 ggttttgcct tcttgttcaa ttgcaaaaac atagcttgtc tgctgatcgt ccagaagcgt 2973481 tttaagcacc ggttcaattt ggattggacc gtcaaacgtg agcagcagct ctcgggcaag 2973541 aacaacctta tcatattgtt tctctttaat ttggcttgtg gccgtttcga ttgctttcag 2973601 ccaatcatcc ttatccagct cttcggctgc tgcaatcaca gcctgatctt cttgcttgaa 2973661 atcgggaacc ataaattccg ccgcaaaagc ttttaagcct tctaaaacag cttctgcgtc 2973721 ttctcctccg cttacccatc tgttaactgt taagaacggg ccttcagcag tcatcgtcag 2973781 cataagcgca ggcacaaaga aatccccttc cgagaaatgg tcccattgtg aacctctttc 2973841 ttcgcaaggg tcaaaagaaa atcctccgaa taacacaggt cccactgcag aatgctgcag 2973901 cttttcttct tcataaatat gaaaagccgt ctttttaaag cgctcccatt gttcaaaaac 2973961 ctcacgatac cgctcgctgt ttttttgatt tgtctggaaa accgcttctt tgccaagacc 2974021 gactattgtc aattcacttt caggatctga ccaaaaaaat cgattgcctg tatatttttt 2974081 tgctccgtaa ttgaaaaatg atagagggtc aagagactcg atttgtctcg aatagcttat 2974141 taagacagca tggttgactt ctttggcttt atgtaatgca tgtagaactt cctttcggaa 2974201 cgtacgctgc accgttgtca ccatgagaca ttcctccata atccttaaaa tgcttttaat 2974261 accatacacc tgtgtctcct ttgtgtcaaa cacagatcat gcagtccaaa tggcctgcct 2974321 tacctattat aaacctaatt tcagaaatga aaaagaaaca aagcttaaat ttctttctcc 2974381 actgatagca aaggttgtat ccgcttacca taaaaggaaa acctcctata ttcctccacc 2974441 cgccatttat gaaagttctc aggcgatctg ttcatactaa aggtatgcat cacagagaaa 2974501 cgaggcgatc acattgctta cgaaagaaca gcttcagcat ttaaaaaatg aactggaaca 2974561 aacgaaaaaa gatatcttaa accgtttcaa agacaatgat cattttcagc ttaactcagc 2974621 ctttccttat gattcgtggg gtgagctttc ggcatacgac aaccatcccg gcgatcaggc 2974681 gacagaactt tacgagcgtg agaaagacat cgctctagac ttgcatgaga gagagcacct 2974741 tcgggacatt gagcattcat tgaaggcgat agaaaacggt acgtatggca tttgtgaagt 2974801 cagcggaaag gaaatccctt tcgaacgact tgaagcgctt ccgactgcca caaccctcgc 2974861 ggagtattcg tcacaggacg tggtttccaa agaccgtccg attgaagaag aaacaccatt 2974921 cgggcaattt gaatttgatg atgatgaaga aatcagagcg ccatatgaca gtgaggattc 2974981 ctatcaggat gtcgaaaaat atgggaactc acaaacgccg caggatatgg aaaaccctcc 2975041 gctcagctat gatgatatga cgatgaatgc cgaagagaat atcggcaata cggagtctta 2975101 cgaaaatttc atcgctacag atatcactgg gaaagaaatt accgtttatc aaagcagagc 2975161 ccatgagcgc tatgaagaag aacttgacga agagggaatc atgaccacat tcggcgatct 2975221 ccacgctgat tgaaccccca attattgggg gttcttttcc gttttcagca tatcgtaaat 2975281 cagcttcaga taatcctttt gcaggccgat gtcataccgc tcgccctcta gcaatttccc 2975341 gtatacggta catgccccga gcgaagcttt tatcgcatcc gttacctgca cttctcctcc 2975401 gctatcagct tctaatgcct ccagctcatt aaaaatatcc ggtgtgaaaa tataacgccc 2975461 tgctgcggca aaatgagacg gagggttttg tttaggcttt tccacaatat cctgtatgcg 2975521 ataaagccct ttttcaacag gctccccttt tatcaccccg taatgatgta aatcctccgt 2975581 ttttgtttct tttaagccga tcacactgga ctgatatttc gtatacgctt caatcagctg 2975641 ccccaaagcc ggctgattgg cggaaaaaat cagatcatct ggcaaaacga cggcaaaagg 2975701 ctctcctcct gcaaattgct ttccgaaaga aatggcgtcg ccaagaccct ttgcataagg 2975761 ctgccgcaca tagtgaatcc gtatatccgg aatgggatgc tctctaagta aatgcagttt 2975821 attcttagag gccaaaaaag cctcaagtgc caaagaggaa tcaaaatagt cgacaatcag 2975881 atttttatgg ctcgatacaa ccatcaaaat gtcctcaatg cctgactcct ttaattcttc 2975941 aacaagataa tgaatcacag gcttagatcc taccggaaac atttctttcg gaatcacctt 2976001 cgtcaccggc agatttctcg tgccgaatcc gcctgcagga atgatcgctt tttttatcat 2976061 ggtattttcc cctcagctca tgtttattac atgatattcc aagagcgcat cccgatgttt 2976121 gtacatctga aattaggcgg aagcaactgg gcagaaagcg gaatcacgaa ccagcccttt 2976181 tttaatagga tattgatata tgaccagtaa tcttgtaaag gagctcaggt gatgaaaatt 2976241 tgtgtggttg gcgccgggta tgtcggttta accctatcag cggcactggc atccatcgga 2976301 catgacatga tatgcacaga caaagacgtc aaaaaaatcg ggcagctgaa aaaaggagtc 2976361 attccctttt acgagcctgg gctttcagat gcaatacttc gttgcggcaa tctctcgttt 2976421 tcttctgaag tgaaatcgag catggaggaa tgtcccgtta tttttatcgc agtcggaact 2976481 ccgccgcgtt cggacggatc agctgatacg aaagccctgc agtccgtcat cggtgattta 2976541 agcgaggcga tccgatcgta taaaaccatt attacgaaaa gcactgttcc gcccgggaca 2976601 aatgaaaaca tagcaaaaca gctgattgcc tccggagtgt ctaaaaacct ctttaatatc 2976661 gtatccaatc cggagtttct gcgggaaggc aatgccttat atgacatgct gcatcctgac 2976721 aaaacagtca tcggtgttca ggaagaagat cacgtatcgg cagccatcgt caaatccatt 2976781 tacaaacaca ttgatacccc ttttatcgtt acaagcttag cgggagcaga gctgatcaaa 2976841 tatgccaaca atttcttttt agcggccaaa atttcgttca ttaacgaaat ggcccgcata 2976901 tgtgaagcct atcaatcaga tatctcagat atttcccgcg ctatcggtct agacccaagg 2976961 atcgggaagc actttttgca ggcaggcatc ggatacggag gctcttgttt tccaaaggat 2977021 ctgcaggcgc tgcaatttgc tgcccaggaa aaaaacacgg agaccttcct gctccgggcc 2977081 gtgcagcaca ttaatgacac ccagcttggc ctgtatatca aaaaaataca gtcattcttc 2977141 gaaacacttc aaggcaagaa agcggctgta ctcggcattt ccttcaaacc gaatactgat 2977201 gacatccgga attctcaggc tgtcagactg atggaaaggc tggcggagct gggatgtgat 2977261 gttcatgcat atgatcctga agctgtactt ccagaacatt tgcggcaaca tgtaactcag 2977321 cattctcaag cttttgatgc gatcgaagag agtgactttt tatttttggc gacagaatgg 2977381 tctgagtttt tagcgtttga ttggaaaaag gctgcagata tcatgaaagg gcgtcttgtg 2977441 attgacggac gcaacgtact aaaaaaagaa ctgatcgagg cttgcggcct gatctgtacg 2977501 ggagttggcc gtccatgaaa atactcgtca caggagcagc gggctttatc ggctcccacc 2977561 tctgcgaaga attactaaaa gataagaaac ataacgttat cggaatcgat gactttatcg 2977621 gtcctactcc attttccttg aaattaaaaa accttaaaaa cctgctgccg gaaaagcgat 2977681 ttacgttcat aaaggaaaat ctgctgacag ccgatcttgc ttccttactg gaaggagtgg 2977741 acgtcatctt tcatttggcg gccataccgg gtgtccgctc aagctggggc aatcattttc 2977801 acccatatgc cgcacataat atccaagcgc tccaaaggct cctcgaggcg tgccgggaac 2977861 attctattca aacgttcgtc tttgcatcca cctcttccgt ctatggcgaa aaacaaggaa 2977921 aagtcagcga aaacacgtcg ctttctcctt tatctccgta cggggtaaca aagcttacgg 2977981 gagaaaagct ttgccatgtg tataaacaga gctttggcat tccaattgtg attctccgtt 2978041 tttttaccgt atacgggcca agacagcggc cggatatggc ttttcaccgg ctcattaagc 2978101 agcaccttca gcaaaagccg cttaccatct tcggtgatgg gcagcagtca agagatttca 2978161 cttatatcag cgactgtgtc aaaggcatca ccgctgttct tgggaaaccc caccttattg 2978221 gtgaaacagt aaatatcggc ggcgcagagc gtgcctcagt cttaaaagtt gtctccctca 2978281 ttgaggatat ttccgggaga aaagcaacac tgcacttttc ggacaaaata gcaggggaac 2978341 cgagcaacac gtgggcggat atttcaaaag caaaacagct cttgcattat gatcccgcca 2978401 catccttaaa ggatggcttg accaacgaaa tcgcctattt atcgtcgctg tatcaggggg 2978461 aataaaaatg aagcttgcct ttatctgtac agaaaagctg ccggcgcccg cagtacgcgg 2978521 cggcgctatt caaatgatga ttgacggtgt cacgccctat ttcagcagca ggtacgacct 2978581 gaccattttt tcaatagaag atccatcgct cccaaaaaga gaaacaaaag acggcgtaca 2978641 ttatatccat ctgccaaaag aacattaccg cgaggcggta gccgaagagc tgcgagcctc 2978701 ttcctttgac ctcattcatg tgttcaacag gcctttaaat gtctctttat ataaaaaagc 2978761 ctcaccaaac agcaagatcg ttctgagcct gcataacgaa atgttttctg aaaaaaagat 2978821 gaccttcgcg caaggaaaag aagtactcga caatgtctcc atgatcacaa cagtgagcga 2978881 atttattaaa caaaccgtca ttgaacgttt ccctgaagcc gaggacatca caaaagttgt 2978941 gtattccggc gttgatttaa actcttatcc gcccgtctgg acgatgaaag gctcggctgt 2979001 cagaaaaaca taccggaaaa aatacggtat tgaagataaa aaagttattt tattcgccgg 2979061 ccgcttaagc ccgacaaaag ggcctcacct tctcattcac agcatgagac ggattttgca 2979121 gcagcaccct gatgctgtac tggtcatagc aggcgggaag tggttcagcg atgacagcga 2979181 aaaccaatat gtcacctatc tgcgcacgct ggcgctgcca tacagagacc acataatctt 2979241 tacaaaattc attcccgcag acgatatccc aaaccttttt ctgatggcag atgtatttgt 2979301 gtgcagctct cagtggaacg aacccctcgc ccgtgtgaat tatgaagcaa tggcggccgg 2979361 cacgccctta attaccacaa accggggcgg aaacggtgaa gtcgtaaaac acgaagtcac 2979421 cggccttgtc atcgatagct acaacaaacc ttcttcattt gcaaaagcaa ttgacagagc 2979481 ctttacagat caagaattaa tgaacaaaat gacaaaaaac gcccgaaagc atgtagaagc 2979541 tttatttacc tttacccatg ctgccaaaag gctcaatact gtttaccaat ccgttctgac 2979601 cccgaaaaac aaacaatttc cgccgccttt tctgacgcaa aattttgatt tatcatctat 2979661 caatcagctt tttgtgaaag caaaaacata aaacctacag ctcgtgttgc aaaacgggct 2979721 gttttttcgc tacagagaac ttaaaaaaag gcataaatgt gactttatgc cttgcgcttt 2979781 acagtttgag aaaaccatgg agctggttta gattcacttg gaagaatgat gatttccact 2979841 ttagcttctt ccgctaagtc tggttcttca tcttcatcct cttcttcata tgggggcgct 2979901 gagcgtttcg aatcacgctc ctcctcaggc tccagagtgg tttcgaattt tgtttcttct 2979961 tcatcatcga cgattttgcg atctgtttcc ttttccttcg tttctttttg atattctttc 2980021 ggtgcattga tgtgagggag ctctcgaatg ctgcccacat ctaaatgctt ctcctcttct 2980081 tccttctcag ctgagattga gtcatgagcc tgccatccca tcggtccagg cggtgtaaat 2980141 acgaattggt cgagatccag tttagaaata gaggcttttt gtctcgatga cctcatgtca 2980201 attcgcctcc cgatacgctt ttatcttttt atacagttcc ggcagtttat ccaaaaacga 2980261 atctttagat tcttcaacag aaatcatgtt ttgcagcgcc cagttatact tctcatctga 2980321 ccacgttttc ttttgcttca aataatattt gtgcccgatt gcacagaaca aatgcggaaa 2980381 cgcgagatca atccaaagta cctcgtactg tttttctgtg agcggataca ctgcgtcgta 2980441 ggccgcaagc agtgcaacca tgaaatcagt atcccataca gaaagcttaa ccatcacttt 2980501 attcagcaga atacgaaggt ctcttgacgg caaatcgtag gtaatcgagt gaagctcctt 2980561 taaaaaaggc tccccttcga tctcagtcaa acgtgccaat gtaaaatcct gaaaacagaa 2980621 tccgccatgc tcgagtgtct cttttgtcca ggtttcgtat tctgagtcat caagcgctct 2980681 gagagcttct tttcctcttg ccagcatttt atcagcatgt tttaagaaag tttgcgaaaa 2980741 tacgtcatca ggataggatg ctgcgatctg catattccct tcaagttcct gcagcttcca 2980801 acggtacaat ttgtgccatt ttcccagcct gcttctcttc ttgctttcat ctgtgcaaac 2980861 atatcctttt gaggcatgat gaaaatggcc ggcaaatgac atgacttttt tcatttgctc 2980921 tgcatcatag taaatcattt cttttcctgt cactttgtca tataaactgt aagaaacctg 2980981 atccgtgccc aagcagctac cgccattttt tgtttgatga atcggcgcta tcggcagccc 2981041 tttctcttgt aaatgggcgt gtgcctgagt gataaaaagc atccgctccg gtttcatttg 2981101 cgcttctttt agcagctttg ggccatgatc agtttcgact tcccagattt tgcgcccgct 2981161 tttgttcgat ttcagcgcca catggtcgat atgaaacgga taataactga gaatttcgga 2981221 cacaatctgt tcttcatgct ctttttggta cactctgttc accccttcta tctgttcttt 2981281 tcatagacgc tgagcagatt ttcagccacc ctctgccagc caaaattgct ttctgcctca 2981341 cggcggctgt atttcccaag ccgttcccgc ttttccgagc tgctcagcaa atcattgata 2981401 cgttcggcat attgtttagg attttcaaag tcatgaatga tgtagccgtt tttcccttcc 2981461 tctatgacct ctggattgcc tccccgattg cttgtaataa taggaagtcc cgcagccatc 2981521 gcttcataat gcacccttgc taaaggctcc tgccattgcg aagagcatac aaatacatct 2981581 gacatggtat aaaggcgcgg aatgtccttt ggcttcacaa attgaataaa tgtgacatga 2981641 tccttttgca tcgcaccaag ggtatgaaga tgtttgacat agttatttaa ttcattatct 2981701 ccgaaccatt ttgacccgat aaacaccatc atgacatcgg ggtgctcctc aatgatgtcc 2981761 ggcaaagcct gcaataatat gtgcgggcct ttgactttgc taagccggcc gacaaacaag 2981821 acgatttttt tgccgtgaag ccccagctcg cttcgcatct cttcgcgagc tcgctgccct 2981881 tcattcgtcc agcgagggtg gtacgttttt aaatccacac cagaatacac cgtttttgtt 2981941 tttgatcgtg ctgacggaaa acggcttgtg atcgtctgtc cgatataatc gctgaccgta 2982001 acaatctgcg ctacggagtc gatgcaaatc tcgccttccg cctggctgat tttatcgtaa 2982061 gcgaacattt cattgtgaac gcttaaaata aaaacagcat ccggcgcctg tttcttcaat 2982121 ttcggaaccc agcttgggcg attacaaaca tgcacaagat caaaacggct ctttttcagc 2982181 tctgctccaa cggcttcttc ataacggtct tcatccaaat gcacataatg gacaccgtct 2982241 accttctctc tatcagcgag attcggatct ttaatagaaa acacagtcac ctcatgtttt 2982301 tttgcaatta aaggggcaac cgcttcgagg tagatttgaa tggcgcctcc tcgaaccgat 2982361 gggacaggaa gcttctctgt ggcgatcagt gctattttca tacatagcct ccattcctgc 2982421 atgattttta actagttaga atcatgatac ggctgaacaa ccaacttgtg cggaatggga 2982481 ctgccctaaa aacaaaacgg gtaaacaacc agattcatct attaaatata gtcaaataac 2982541 tcaatcattt tttccttttg attcataagg taggagtaaa acaggtaagg atgtgtcctt 2982601 taatggcaga aaaccatgaa gtcattgagg aggggaattc atcagagctt cctttatcag 2982661 cagaagatgc aaaaaaatta acggagctgg ctgaaaatgt gcttcaagga tgggatgtgc 2982721 aggctgaaaa aatagacgtc attcagggaa accagatggc gcttgtctgg aaggtccaca 2982781 cagactccgg cgcggtttgt ctaaaacgaa tacacaggcc agaaaagaaa gcgttgtttt 2982841 ccattttcgc gcaggactat ttagcaaaaa aaggcatgaa tgttcctggc atactcccaa 2982901 acaaaaaagg cagcctatat tctaagcacg gctcatttct atttgtcgta tatgactgga 2982961 tcgaaggaag accgtttgag ctgactgtaa agcaggactt ggagtttatc atgaaaggcc 2983021 ttgctgattt tcatacagct tccgtcggat atcagccgcc aaatggcgtt cccatattta 2983081 ccaaattagg tcgctggccg aatcactaca cgaaacgatg caaacagatg gaaacgtgga 2983141 agctgatggc ggaggcggaa aaagaagatc ctttctcaca gctttatctt caggagatag 2983201 atggctttat tgaagacggg ctgcgcatca aagaccggct tttgcaatcg acctatgttc 2983261 catggactga acagctgaaa aaaagcccta acctttgcca ccaggattac ggaaccggga 2983321 atacactctt aggagaaaat gaacagattt gggtcatcga cttagatacc gtatcatttg 2983381 atctgcctat tcgcgatttg cgcaaaatga ttattccgct tttggatacg acgggtgttt 2983441 gggatgacga aacatttaat gtcatgctga acgcatacga atccagagcc ccattaactg 2983501 aagaacaaaa acaagtcatg tttattgata tgctgtttcc ttacgagctt tacgatgtca 2983561 ttcgcgaaaa atacgtccgc aagtctgctt taccgaagga agaattagaa tcagcttttg 2983621 aatatgaacg cattaaagca aacgcattgc ggcagcttat ttaagaccat catttccccc 2983681 gcatatcggg ggtttgatat ttataagata aagggtaatt aaatacatgc ggaggttgca 2983741 aatatgaaaa agattgtcgg cgctttagcc gtttttgtga ttacatatgc gctgttttca 2983801 gccgcaggct acctgtttcc tgtggaccaa gaatggtaca attcattgaa aaaaccggac 2983861 tggacgccaa gcggaactgc gatcggcatc atttgggcca tcctgtttgc cctgatctcc 2983921 ctttcagcag ccattgtata tgctgcgttt tcatttaaag gtgcgaaaag cttttggttt 2983981 acacttttga taaattacgt gctcaatcaa gccttcagct atttccagtt tacgcaaaaa 2984041 aatctgctgg ctgcatcgct tgactgcctg cttgtcgcca tcacagcaat cgtattactg 2984101 atcattgcca aaaaatacag cagagccgca agctatcttc ttttgcctta ttttttatgg 2984161 agtgcatttg cgacgttctt atcctttaca atcaattcaa tgaatctgtg aacaaaaaaa 2984221 gccgcttata cagcggcttt ttcacatcat cggcttgatg ccccaaatgt ccttcgcata 2984281 ttcccggatc gtgcggtcgc tggagaaata tccagaatga gcaatgttta caatcgaatg 2984341 ctcagaccat ttccttcgct ctcgataatc agcttgaatt cgctcctgtg catctgcata 2984401 tgagctgaaa tccttcagca caaaatactc atcattatgc ggaagcagcg agtcaaagat 2984461 cgattcaaat tcatctgcct ctccttcaaa aaaaccattg atcaactgat ccgctacctg 2984521 cctgattctc ctgtcatgct gataatattc cctcgaccta tagccgccgt tttcctgata 2984581 cgatagaacc tcatccgcct ttaagccgaa cgtgtaaata cagtcagggc ccacccgctc 2984641 aaggatctcg atatttgcgc cgtcatgcgt gccgatcgtc aaagccccgt tcatcataaa 2984701 cttcatattc cctgtaccag acgcttcctt gcttgcggtt gaaatttgct cacttacgtc 2984761 tgatgccgga aaaattcgct cagccataga aactctataa ttttctaaaa aaacaacttt 2984821 gatcagctgt ttgaccgccg gatcataatt gactttttct gcgacagaat ggatcagctt 2984881 aatgattttc ttggcataat aatagcttgg tgaagccttt gccccgaaaa taaaggtttg 2984941 cgggtagatt gaaaaccccg aatcctcctt gaggcggtta tacaaataca taatgtgaag 2985001 aacattcagc agctgccgtt tatatgcatg aagccgtttc acctgtacgt cgaatatgct 2985061 ctcagggttc acaaccaccc cggccgtgca aaaaatcaaa tcggcaagct cttgtttttt 2985121 cttgcttttg ttgttttgaa actgttcaat aaatgcagga tcagtggcgt acggttctaa 2985181 acggatcagt gattccggct gcttgaccca ttcatcgccg atcgcctctg taatgatggc 2985241 agacaagcct ggattcgctt ttaacagcca gcgcctgtgg gcaattccat tcgtcttatt 2985301 gttaaaacga ttcggaaaca gcaagtgaaa gtcgcgcatc tccctttcct ttaatatatc 2985361 ggaatgtatt tttgcaacgc catttacact gtagctgcct actatggcca gatgagccat 2985421 tttgacaaca ccatgcgctg taatcgccat gttctctatc cttttccagt ctccaggata 2985481 cttttcccaa actgcacggc aaaacctctc attgatctct tcaataatca tgtacattcg 2985541 cgggagcagc ggcttaaaca aatgaatcgg ccatttctcg agcgcttctg acaatgttgt 2985601 atgatttgta taagaaatcg tatgtacagt gatatgccaa gcttcttccc agctcatgtt 2985661 ctcttcatcg agcaaaatcc gcattagctc aggcaccgca agcgcagggt gagtgtcatt 2985721 aatatgaatg ctcacttttt tatgcaggcc ggataaagat ttatgtgttt tacggtaatt 2985781 gttcacaatg ctttttaagc ttgcgcatac taaaaaatac tgctgcttca gccgtaaaat 2985841 tttcccctca tcatgggtgt catcgggata taagaattca gaaaccgctt ctgtttctcg 2985901 cttataagac aaaatattac cgccgtgata atgggcatag ggctcggcgt tccaaagcct 2985961 taacgtgttg acagtgcccg tttcatagcc gatgatcggg atatcataag gaacagcggt 2986021 aacaattgtc gcttgttcat ggcgaaaatg caggcgcccg cttttttctg tcatatggac 2986081 ttcgccccaa aacggcacgt ccactgcttg atccgcattc cttacttccc atacgttccc 2986141 gtttttcagc cattgctcag gcagctccac ctgatgtccg tctacaattt tttgctcaaa 2986201 caaaccatgc ttataacgta tgcccatgcc gtgcccaggc aggttcaacg aagcaagcga 2986261 atctaaaaag caagcggcca agcgcccaag tccgccattg ccgagacctg catcgttctc 2986321 tatctgaagg atctcctcta aattgatgcc gatttccttt aaaccagctt ctacaacatc 2986381 acgaacacca agattcatta agttttgctc aaggagctga ccgagcagaa attcgattga 2986441 taaataatat gtctgcttcc cggaatttga tctgcttttt tcattcgttt cgatccaatc 2986501 agcgctgata tactctctga ccatattgcc caacgtttta tattgatcca gcttggcaga 2986561 atctttaaag ctttttccgc acgtcatttc cagacgcttt aaaaataagt ctgcaaagcg 2986621 ttctttactc gagaacatcc cgtccactcc ttgtcacctg ctcgaaaata cgctgatact 2986681 ctttagccga cttcccccag ctgtaatctg cattcatagc ggtcttcacg atgctcttcc 2986741 atacatcctg ttggcaataa aacgacagcg ccctttctat cgtaaatttc agatcatgcg 2986801 cattaaaggc ggaaaacgta aagccattgc ccgttccctc ttcctcctga taggcacgga 2986861 cagtgtcgta aagaccgccc gtttccctga caatcggaat ggcgccatat tgaagagcaa 2986921 tgagctgccc caaaccgcac ggctcaaatt tcgacggcat caaaaacata tcagagcccg 2986981 cataaatttg atgggctagc ggctcatcaa acccgatata agcccggcac ttctcatgaa 2987041 aagcaaattc tgcataccgg aaataatctt caaattcacg ttctcctgtg cctagcacaa 2987101 ccagctgtat gtcttgctcc tcaagaagtt cgtgcataat tctgcggaca agatcaagcc 2987161 ccttttgttt agtgagcctt gtcaccatac tgatcagcgg aatatcgttt ttctctggaa 2987221 gccccatccg ctgctgaagc ttcgttttgt tttccagctt gcatgcaaga tcccctgaat 2987281 cgtattgcgc ctctatataa gggtcgcttt tcggctgata gaacgtatca tcaatgccat 2987341 ttaatatgcc ggttacatca tcttccctat attgcaaaac ctgttccaac tgctcaccat 2987401 aatacggcgt catgatttca tttctgtaag tggggctcac agttgtcaca tgatcagccg 2987461 caatgatgcc cgctttcata aaattaacaa atccgttgca ttctaacctt tcataatgaa 2987521 aatgatccat ctcaagaccc agcaagtcat gtgtgacatc aggagggaat atgccttgaa 2987581 actgcaggtt gtggatcgtg agcacgcttt tcatccgttc ataaaaagga tgttttctgt 2987641 actcctcttt cagcaaataa ttgaccatcg ctgtatgcca atcgtgagta tgaacaatat 2987701 cggcttgaac attcacaact ttggcagcct ccagcacagc tcttgaaaaa aaggcaaacc 2987761 gctcaccgtc atcataatgc ccgtacaacg aatccctgtt gaaatagtac tcattgtcga 2987821 tgaagtaata attcacatca ttctctgcca tatgttcaat tccgcaatat tgctgccgcc 2987881 agccgacagc tacggtacac tcagcctgtt ttttcatacg ctttttccac ggttcaggta 2987941 tttggctgta cttcggcagc atcacagcta cctcattgcc taatcgcgca agcgcctttg 2988001 gcagagcacc tgctacatcg gcaagacctc ctgatttcac aaatggggtg cattctgaca 2988061 cagcaaataa tatcttcaag aattcatcag ctctccttgc accaaacctt ttcttaatac 2988121 aagcggctgc tcagctgttc ctgcagcttc cgtcgccttg ccgattttaa catccttatc 2988181 cgaaatgacc tgctcaagaa gacaatcctc tccaatctgc gttttttgca taataatgca 2988241 gtttttcagc ttcgtaccct ttccgacatg gaccgccctg aacaaaatgc agttttcaac 2988301 ctctccttca agcacacagc cgtttgccac caaagaattt ttgacagtgc tgtgctttcc 2988361 gtatttcgta ggcggctcat ccttcacttt tgtatagatc ggctgctgcg gcaaaaacac 2988421 ctgctgccaa aaacgaggct gaatgagctc catactgtgg gtataatatt tttccaccga 2988481 atcaatgaca gcggcataac ctgaatattc ataagggcaa atggtcaggg cggaagattc 2988541 cttttcaaca gcctcctgaa tggttttata gcctttttcg ctatgtccgt agatcagatc 2988601 ctttaaaagc gttgttgaca tgatatagat ttgcagcgac tggccgtcct gaaatacctc 2988661 ggtgacgtcg cagccaacct cctgatggcg tttcagcaca tattgaaatt gaatgttgca 2988721 tacggtatgg ctgttggaga ttacagcata ttgctgagtg cttctgtgga agtaatctag 2988781 atggtccgaa aactggcgaa aggaaccgaa ttcatcgtat tcgtgatgaa gatggggaga 2988841 cgggaaaaaa aagaggccgt cctttttccg gtgcaaatcc cattccttac ccgccccaag 2988901 gtgatccatg agcgaacggt aacgatactt cggaaaaatt gcaacactcc taatatccgc 2988961 attcaccatg ttggaaagca taaaatcaat cagtcggtac ctgccggcaa aagggatcgc 2989021 cccgagcgac cgctgtgctg ttaaatcctg aagagaatgc ttatatgtgg tttcatctat 2989081 aacacctaac atttgattat tgaacactga ctctgccccc tcttcagtaa ttaaatcaat 2989141 tctttttcta caaattcctc tgaaacgagc agcacctctt caatgtcttt ttcggagcga 2989201 atcactgcgc catccggcag caccatccca ttaggaacga tggcattttc aatgactaca 2989261 tgctccccaa tcgtcacatc cggcattatg acggatgatg taacagtcgt atgcttacca 2989321 acagtcacac cttgaaaaag aacggagtga gacacatttc catatacaac acaaccttcg 2989381 ttcacaagcg aatcttgaac ctgcgcatca gatgaaataa attgcggagg ctgatttgga 2989441 ttgacggagt aaattttcca tttgcgttca aacagcttca gctccgagtc ctcttttaac 2989501 aaatccatat tggcttccca caagctctgc accgttccga catccttcca atatcccttg 2989561 aacggataag cagaaagctt ctttttctct tccaaaagca gtggaataat gtctttgccg 2989621 aagtcgtggc tagaataagg gttttgatcg tccatctcaa gatactgttt caaaagcggc 2989681 caattgaata tataaattcc cattgaggca agattgctct tagggaattt gggcttttca 2989741 tcaaaatgtg tgatcgtccc atctggattg gccttcatga tgccgaaccg gcttgcttcc 2989801 tcccagccca cttcgatgac agagatggtc acatctgctt tcttttcaat gtgataatca 2989861 agcattttgc cgtagtccat tttgtatatg tgatctcctg ataaaatcag tacatactca 2989921 ggatcatact gattcaaata attgagattt tcataaatgg agcttgccgt ccctttatac 2989981 catttgactt ctgatgactc ggcataaggg ggtaaaaccg tcacgccgcc attatatcta 2990041 tccaggtccc atgcactgcc gatcccaata taggaattca gctcgagcgg ctgatattgc 2990101 gttaaaatcc cgactgtgtc tatgcctgaa ttagaacagt tgcttagggt aaaatcaata 2990161 atcctgtatt ttcccccgaa agatacagcc ggtttggcca tattttttgt taatccgctg 2990221 agacggctgc ccttcccgcc ggcaaggagc atggctacac attgtttttt catcttttta 2990281 tctctcctct ttttttaacc gcccgtaaaa tcgagatgcc gtaagggggg atggtcatcg 2990341 tgatataaca cggtttatga tgaagtgctc cctttttagc cgataacggc tttttgttga 2990401 tttgccctga gcctccatat gtttcactgt cactgttaag cacttcaatg tattgagtaa 2990461 aaaaaggaac tccaacatca tattgatgat agaccacggg tgtaaaatta caaatgatga 2990521 caagcgcctc accgtgcttt tggccataac gaataaaaga aaagattgat tgttcgtcat 2990581 tatggacatc aatccattca aacgattgtg cacgatggtc atgctcataa aggattttgc 2990641 ttttttggta aaagcggaga agatcttgcg taaaaacgct ggctttctga tgcatgggga 2990701 aggagtccaa aaaccaatca agctgttctg tatctttcca ttcatcaaat tgagcaaact 2990761 ctgatcccat aaagatcaat ttctttccgg gatgcactgt catatagccc agcaaaagcc 2990821 gatactgggc aaatttctgc cagtagtcgc caggcatttt attgagaagt gatttttttc 2990881 cgtatacgac ttcatcatga gaaaacggca atacaaaatg ttcactaaac gcatatagta 2990941 atgaaaaaga gataagctga tgacaatgcc gcctttcttc gggcggcgtc tccatgtatt 2991001 tcagtacgtc attcatccat cccatattcc atttataatg aaaaccaagc cccccttcct 2991061 caacggcacc tgtcacttga ggccattctg tagaatcttc tgcaatcatc atcacatggg 2991121 gatatgcctc tctcatggtt tgattgagtt tttttaaaaa atcaacagca tatggattcg 2991181 tgtggcgttc atcctgattt ggccaataca agatattagc cactgcatca accctaaatc 2991241 catctatatg atagaattcc gcccagtaca acgcattcga aattaaaaaa ctatgaactt 2991301 ccggtttccc caggtcaaag tttgccgtgc cccataacca gttctcccga tcacgttctt 2991361 ctttgtattc ataaagcggt tctccatcaa acatataaag gccatgtgca tctttacaaa 2991421 aatgtccggg gacccaatcc aaaatgactc cgatattttg ttgatgacat tcatccacaa 2991481 acttcatcag atcatgcggc gggccaaacc tgcttgtcgg gctgtaatac cccgttcctt 2991541 ggtaccccca tgaacgatca tatggatgct catacacggg aagcagttca atatgggtaa 2991601 acccatgctt cttgatataa gggataagcg tctgacttaa ttctttatag gaataatgcc 2991661 tgccatcaga atgcttcttc caagacccaa gatgcagttc ataaatgaaa acaggttttt 2991721 catacagcgt cttagccttc tgtttctttt gccatttttg atcttgccag ctgtatcctt 2991781 ccaaatcgta agtaagtgac gctgtgtttg gtctgacttc tgaataaata gcgtatggat 2991841 ctgccttcag cctgatctca ccgttattcg tcacaatttc gtatttatat cgttcctttt 2991901 ctcctatacc tggaataaat aacgtccaaa tgccattatc attcactctg tgcatcacat 2991961 gctcttctcc agaccagctg ttaaaatctc cagccactcg tacttccgac gcatgaggcg 2992021 cccacacaca gaattcatat ccgcttttgc cattcagctc gcggtaatgc gagccaaaca 2992081 gctgatagct tttaaacaga ctgccttcgt gaaaaagata aacatcatgt gctgtcgggc 2992141 tggcagcggc catgtaatca tcctttctga catcatagtt ttcatttata gtatttattc 2992201 gaagaaataa aaaaaagccc tttcctgaaa gcgcttatac ttatagacaa ttaacttcat 2992261 tttctgaaga aaaacgaaat atatggagat ttttgtagtc tgtttttaaa ataaagaaca 2992321 aaatctaaga catatcatga tttataaaaa caaaaaaacc ttgcaggata tgcaaggctt 2992381 ctggatgacc cgtacgggat tcgaacccgt gttaccgccg tgaaagggcg gtgtcttaac 2992441 cgcttgacca acgggccgat aattatgata tctgtaatca tatggcggag aaggagggat 2992501 ttgaaccctc gcgccgctta cacgacctac acccttagca ggggcgcctc ttcagccact 2992561 tgagtacttc tccatttggc tccacaggca ggattcgaac ctgcgaccga tcggttaaca 2992621 gccgatagct ctaccactga gctactgtgg aacaaaagtc atggtgggcc tgaatggact 2992681 cgaaccatcg acctcacgct tatcaggcgt gcgctctaac cagctgagct acaggcccat 2992741 gacgatatag aaatggagcg ggtgatggga atcgaaccca cgacatcagc ttggaaggct 2992801 gaggttttac cactaaacta cacccgcaat ttttatttgg ggcgattgat gggaatcgaa 2992861 cccacgaatg ccagagccac aatctggtgc gttaaccact tcgccacaac cgccaaagca 2992921 tattgataaa tggtggctcg ggacggaatc gaaccgccga cacacggatt ttcagtccgt 2992981 tgctctacca actgagctac cgagcctaag tatttaaatg gcggtccgga cgggactcga 2993041 acccgcgacc tcctgcgtga caggcaggca ttctaaccaa ctgaactacc ggaccatttt 2993101 aaaatttggt tgcgggggca ggatttgaac ctgcgacctt cgggttatga gcccgacgag 2993161 ctaccgaact gctccacccc gcgatgatta ggaatatgta tggcggagga agagggattc 2993221 gaacccccgc gggctttgac acccctgtcg gttttcaaga ccgatccctt cagccagact 2993281 tgggtattcc tccgtatagt ggtggacctt gtaggactcg aacctacgac cggacggtta 2993341 tgagccgtct gctctaacca actgagctaa aggtccattg gtagcggcgg aggggatcga 2993401 acccccgacc tcacgggtat gaaccgtacg ctctagccag ctgagctaca ccgccaaata 2993461 tttttgaaat caagtggagc ctagcgggat cgaaccgctg acctcctgcg tgcaaagcag 2993521 gcgctctccc agctgagcta aggccccaag aatggtcggg aagacaggat tcgaacctgc 2993581 gaccccatgg tcccaaacca tgtgctctac caagctgagc tacttcccga tttcatatag 2993641 atcatggcgc gcccgagagg agtcgaaccc ctaacctttt gatccgtagt caaacgctct 2993701 atccaattga gctacgggcg caaaacttaa tgccgagggc cggacttgaa ccggcacggt 2993761 agtcacctac cgcaggattt taagtcctgt gtgtctgcca attccaccac cccggcgtgg 2993821 atggtatagt tggagcggaa gacgggattc gaacccgcga cccccacctt ggcaaggtgg 2993881 tgttctacca ctgaactact tccgcagaaa tggtgcggat gaagggactt gaacccccac 2993941 gtctgtaaag acactagagc ctgattctag cgcgtctgcc aattccgcca catccgcaac 2994001 atgtaaatgg tgagccatga aggactcgaa ccttcgaccc tctgattaaa agtcagatgc 2994061 tctaccaact gagctaatgg ctcttcttac aatagacttg aatattatat catataaaag 2994121 tggtgccggc aagaggactt gaacccccaa cctactgatt acaagtcagt tgctctacca 2994181 attgagctac accggcatat atgtaaaacc gatatgtata atgaaaaatg gtggaggatg 2994241 acgggctcga accgccgacc ctctgcttgt aaggcagatg ctctcccagc tgagctaatc 2994301 ctccatactt gcactaacgt gcaattgctt ggcggcgtcc tactctcaca gggggaaacc 2994361 cccgactacc atcggcgctg aagagcttaa cttccgtgtt cggtatggga acgggtgtga 2994421 cctcttcgct atcgccacca aacaaattga gagtgttctc tcaaaactag ataacaggtg 2994481 tgacatcatt caaaaatatg gttaagtcct cgatcgatta gtatctgtca gctccatgtg 2994541 ttgccacact tccacctcag acctatcaac ctgatcatct ttcagggatc ttacttcctt 2994601 gcggaatggg aaatctcatc ttgagggggg cttcatgctt agatgctttc agcacttatc 2994661 ccgtccgcac atagctaccc agcgatgccc ttggcagaac aactggtaca ccagcggtgc 2994721 gtccatcccg gtcctctcgt actaaggaca gctcctctca aatttcctgc gcccgcgacg 2994781 gatagggacc gaactgtctc acgacgttct gaacccagct cgcgtaccgc tttaatgggc 2994841 gaacagccca acccttggga ccgactacag ccccaggatg cgatgagccg acatcgaggt 2994901 gccaaacctc cccgtcgatg tggactcttg ggggagataa gcctgttatc cccggggtag 2994961 cttttatccg ttgagcgatg gcccttccat gcggaaccac cggatcacta agcccgactt 2995021 tcgtccctgc tcgacttgta ggtctcgcag tcaagctccc ttgtgccttt acactctgcg 2995081 aatgatttcc aaccattctg agggaacctt tgggcgcctc cgttaccttt taggaggcga 2995141 ccgccccagt caaactgccc acctgacact gtctccccgc ccgataaggg cggcgggtta 2995201 gaaggtcaat acagccaggg tagtatccca ccgatgcctc caccgaagct ggcgctccgg 2995261 tttccaaggc tcctacctat cctgtacaag ctgtaccaac attcaatatc aggctgcagt 2995321 aaagctccac ggggtctttc cgtcctgtcg cgggtaacct gcatcttcac aggtactata 2995381 atttcaccga gtctctcgtt gagacagtgc ccagatcgtt gcgcctttcg tgcgggtcgg 2995441 aacttacccg acaaggaatt tcgctacctt aggaccgtta tagttacggc cgccgtttac 2995501 tggggcttca attcgcacct tcgcttacgc taagcgctcc tcttaacctt ccagcaccgg 2995561 gcaggcgtca gcccctatac ttcgccttac ggcttcgcag agacctgtgt ttttgctaaa 2995621 cagtcgcctg ggcctattca ctgcggctct ctcgggcttg caccctaaca gagcacccct 2995681 tctcccgaag ttacggggtc attttgccga gttccttaac gagagttctc tcgatcacct 2995741 taggattctc tcctcgccta cctgtgtcgg tttgcggtac gggcacctct cacctcgcta 2995801 gaggcttttc ttggcagtgt ggaatcagga acttcgctac tatatttcgc tcgccatcac 2995861 agctcagcct tatgggaaac ggatttgcct atttcccagc ctaactgctt ggacgcggat 2995921 atccaatacc gcgcttaccc tatcctcctg cgtcccccca ttgctcaaat ggtgaggagg 2995981 tggtacagga atatcaacct gttgtccatc gcctacgcct ttcggcctcg gcttaggtcc 2996041 cgactaaccc tgagcggacg agccttcctc aggaaacctt aggcattcgg tggaggggat 2996101 tctcacccct ctttcgctac tcataccggc attctcactt ctaagcgctc caccagtcct 2996161 tccggtctgg cttcacagcc cttagaacgc tctcctacca ctgttcgaag aacagtccgc 2996221 agcttcggtg atacgtttag ccccggtaca ttttcggcgc agagtcactc gaccagtgag 2996281 ctattacgca ctctttaaat ggtggctgct tctaagccaa catcctggtt gtctaagcaa 2996341 ctccacatcc ttttccactt aacgtatact ttgggacctt agctggcggt ctgggctgtt 2996401 tccctttcga ctacggatct tatcactcgc agtctgactc ccaaggataa gtcattggca 2996461 ttcggagttt gactgaattc ggtaacccgg taggggcccc tagtccaatc agtgctctac 2996521 ctccaagact cttaccttga ggctagccct aaagctattt cggagagaac cagctatctc 2996581 caggttcgat tggcatttca cccctaccca cacctcatcc ccgcactttt caacgtgcgt 2996641 gggttcgggc ctccattcag tgttacctga acttcaccct ggacatgggt agatcacctg 2996701 gtttcgggtc tacgaccacg tactcatgcg ccctattcag actcgctttc gctgcggctc 2996761 cgcatcttct gcttaacctt gcacgggatc gtaactcgcc ggttcattct acaaaaggca 2996821 cgccatcacc cgttaacggg ctctgactac ttgtaggcac acggtttcag gatctctttc 2996881 actccccttc cggggtgctt ttcacctttc cctcacggta ctggttcact atcggtcact 2996941 agggagtatt tagccttggg agatggtcct cccggattcc gacggaattt cacgtgttcc 2997001 gccgtactca ggatccactc aggagagaac gaagttttga ctacagggct gttacctcct 2997061 atggcgggcc tttccagacc tcttcatcta cctcgttctt ttgtaactcc gtacagagtg 2997121 tcctacaacc ccaagaggca agcctcttgg tttgggctga tcccgtttcg ctcgccgcta 2997181 ctcagggaat cgcatttgct ttctcttcct ccgggtactt agatgtttca gttccccggg 2997241 tctgccttct catatcctat gaattcagat atggatacca ctccattacg agtggtgggt 2997301 ttccccattc ggaaatctcc ggatcaaagc ttgcttacag ctccccgaag catatcggtg 2997361 ttcgtcccgt ccttcatcgg ctcctagtgc caaggcatcc accgtgcgcc ctttctaact 2997421 taaccgttaa aaagaatcac tatgtgatat cttgtgttac taattgaatg tgatgtctac 2997481 tgttatctag ttttcaaaga acacgtttcg aaggaatgat ccttcaaaac taaacaagac 2997541 agggaacgtt ctgtttataa gaccttgggt cttatattcc gtataatatc cttagaaagg 2997601 aggtgatcca gccgcacctt ccgatacggc taccttgtta cgacttcacc ccaatcatct 2997661 gtcccacctt cggcggctgg ctcctaaaag gttacctcac cgacttcggg tgttacaaac 2997721 tctcgtggtg tgacgggcgg tgtgtacaag gcccgggaac gtattcaccg cggcatgctg 2997781 atccgcgatt actagcgatt ccagcttcac gcagtcgagt tgcagactgc gatccgaact 2997841 gagaacagat ttgtgggatt ggcttaacct cgcggtttcg ctgccctttg ttctgtccat 2997901 tgtagcacgt gtgtagccca ggtcataagg ggcatgatga tttgacgtca tccccacctt 2997961 cctccggttt gtcaccggca gtcaccttag agtgcccaac tgaatgctgg caactaagat 2998021 caagggttgc gctcgttgcg ggacttaacc caacatctca cgacacgagc tgacgacaac 2998081 catgcaccac ctgtcactct gcccccgaag gggacgtcct atctctagga ttgtcagagg 2998141 atgtcaagac ctggtaaggt tcttcgcgtt gcttcgaatt aaaccacatg ctccaccgct 2998201 tgtgcgggcc cccgtcaatt cctttgagtt tcagtcttgc gaccgtactc cccaggcgga 2998261 gtgcttaatg cgttagctgc agcactaagg ggcggaaacc ccctaacact tagcactcat 2998321 cgtttacggc gtggactacc agggtatcta atcctgttcg ctccccacgc tttcgctcct 2998381 cagcgtcagt tacagaccag agagtcgcct tcgccactgg tgttcctcca catctctacg 2998441 catttcaccg ctacacgtgg aattccactc tcctcttctg cactcaagtt ccccagtttc 2998501 caatgaccct ccccggttga gccgggggct ttcacatcag acttaagaaa ccgcctgcga 2998561 gccctttacg cccaataatt ccggaaaacg cttgccacct acgtattacc gcggctgctg 2998621 gcacgtagtt agccgtggct ttctggttag gtaccgtcaa ggtaccgccc tgttcgaacg 2998681 gtacttgttc ttccctaaca acagagcttt acgatccgaa aaccttcatc actcacgcgg 2998741 cgttgctccg tcagactttc gtccattgcg gaagattccc tactgctgcc tcccgtagga 2998801 gtctgggccg tgtctcagtc ccagtgtggc cgatcaccct ctcaggtcgg ctacgcatcg 2998861 ttgccttggt gagccgttac ctcaccaact agctaatgcg ccgcgggtcc atctgtaagt 2998921 ggtagccgaa gccacctttt atgtttgaat catgcggttc aaacaaccat ccggtattag 2998981 ccccggtttc ccggagttat cccagtctta caggcaggtt acccacgtgt tactcacccg 2999041 tccgccgcta acatcaggga gcaagctccc acctgtccgc tcgacttgca tgtattaggc 2999101 acgccgccag cgttcgtcct gagccaggat caaactctcc gataaatgga tcacaggtta 2999161 agttcaccgc atcctgcggc gacacctgtg tgacctgcgt cgtgcaggcc ctagtttgac 2999221 tgactacgca catcgcagtg cgatttttaa aaactgaatt aacaggtacg ttttgtcttg 2999281 tttagttttc aaagatcatt tcgttacttc tcaatgaagc agctttacta atataacatt 2999341 cagcttcttt tttgtcaaca acttttttca agttgttttg aagcatctag tttgtgtccg 2999401 ctgtgcatca gcgacgttta ataatataac acctgtattt atttattgca atagtttttt 2999461 aaaaaaaatc tataaaacaa ataaactata atcctcgcca tgatttctaa agcgtgtgta 2999521 tcatataagt ttcttaaaag aacatataca tcagtcatgt gatcttgttg tttttttcgt 2999581 tttcttgtat agtagaaacg aactaaatac tgatgaccac aaggggagca ttaaagctga 2999641 gagtgagcgg tttcgttctg accctttgaa cctgttagtt aacgctggcg tagggatgtg 2999701 gcaaagtcaa atgaattgca gatcgtaaag cagtgcgtgg aacttttctc atccttccgc 2999761 gtgctgcttt tttgttgtcc ttttggttgt ctgtcaatgg aaggagatag atatgaatca 2999821 atctaagcaa ctggttcgcc ttattgaaat tgccattatg acagcggcag ccgttatttt 2999881 agacattgtc tcaggaatgt ttcttagcat gcctcaagga ggctcggtct ccatcatgat 2999941 gattccgatc tttttaattt cgtttcgctg gggtgtcaaa gcaggtctta ctacaggttt 3000001 gttgacaggt ctagtacaaa tagcaatcgg aaacttgttt gctcaacatc ctgtacagct 3000061 attgttagat tacattgtcg ctttcgcagc aatcggcata agcggctgtt tcgcttcttc 3000121 tgtccgtaaa gccgctgtat caaaaacaaa agggaaattg attgtttcag tggtcagcgc 3000181 agtttttatc ggcagtttgc tgcgctatgc cgcgcatgtc atttcaggag ctgtgttttt 3000241 cggcagcttt gctccaaaag gaacaccggt atggatttat tctttaactt ataatgcgac 3000301 ttacatggtt ccttcattca ttatttgtgc aattgtccta tgtttattat ttatgacagc 3000361 accccgtctg cttaaaagtg acaaagcgta aaagtaacaa tcccccagcg aattccgctg 3000421 ggggattttt cgttatctgt taagaagtgt ttttaaagct gaaagatccg gccagccaag 3000481 acctacttct ttcagcctta ctccggcaat ttcaaagttg tcctccgcta ctctttcagg 3000541 tgaataggcc tgataaaata taatcgaggg attctgctca ataacccaaa caaacatact 3000601 tgaaaaacca tgttgaagca aaaactccgc tccttttgct aagagcgccc tgcctgcacc 3000661 ttgccgctgg cgctcttcca gaagataaat agcgtataac tcgccgtcat agccttcttg 3000721 ttcagagcga ataggtccaa atgaagcaaa gccgaatact gaaccctttt cgtcctgagc 3000781 aacaaatact ccctttaacg agcgactttt ccatttgtct tcaaattcct tatagttcag 3000841 gctgtttaaa taatcaatcg ggataatttc gtggtatgtt gtcctccagc tgtctacatg 3000901 cacttttgca atgtccttta tatcctctaa cttcgcttca cgtacagtta ccatacggtt 3000961 ctgccctttc cttactctga tttttggatc gttttggctt ctttgatttc atttgttaat 3001021 tcattaatgc tttgttttac gtttcctttt cctgaaaagt tctcaagcat ttcttttaca 3001081 tcaattcctg aggatgcttt taaactttct tgcagacttg acattaagtt cgtcgcatag 3001141 ctggttactt tgtttgctcc gcttgattca ccgcttcctc ctgtatcgac aacggtgatt 3001201 ttatcaatat ttgaaagagg tgccgctgct tgtttcgcgt attccggaag cattttgaca 3001261 atcatatcga aaatcgccgc ctgcccgtac tgttcaaagg cggccgcaat tttctctttt 3001321 gcttccgctt ctgcaagacc tttcaggcgg ataacctctg cttctgtctc tcctttcgct 3001381 ttttccgctt ctgcttttgc tagcccgtca attcttactt tttccgcctc agcctttgcc 3001441 attgcttcaa tactgtactt cttggcatcg gcttccgcga gctgtttggc tttctcagct 3001501 gctgcggact gctcaacaga ataacggtct gcatcggctt ttttctttac ctctgagtcg 3001561 tattgacgtt cacggcgaag aatttctttt tcttctagtt ctatttgttt ttggcgttcg 3001621 ataattttaa cctgcatttc ctgctctgtg acttgctggc gcgctcgggc agtctctaaa 3001681 tcatatgctt ggtcggcatt cgcttttgcc gtatcttgtt ctctgcggaa ttcagccatt 3001741 ttgagctgat tgattttttc agcttcagcg atttccgtcg cccgttcaag ttctgatttt 3001801 tttgcgtctt tatcggcttc tgcccgctta attcgggttt ctttatcagc ctctgctgtt 3001861 gcgatatcag catcgcgttt tacttgggca attctcggtt tccctaatga ttcaagataa 3001921 ccgtttttat cacgaacatc tttaatggta aacgagacga ttacaagtcc cattttcgcg 3001981 agatcctgtg aagcgacacg ctgcacctct tgagagaatt tttctctgtt tttatagatt 3002041 tcttctactg tcattgagcc gagaatggaa cgaaggtggc cttctaaaac ctcccgcgct 3002101 tcctgctcac ggtcgtcttt tgatttccct aaaaattgtt cggccgctgt agcgatttct 3002161 cctatagaac cgccgatttt aataatcgca gttccatcgg ccattactgg cactccttgt 3002221 tctgtataga cttcaggtgt cgaaacatcg agtttgcttg ataataggct tagcggctct 3002281 gcctgctgga agacgggaag gacaaaggtt cctccgccgc ggacgatttt aatacggttg 3002341 ccgccttcat cgacatgaac atttttatta cccagatagc tccctgttac aattaacgct 3002401 tcatcaggcc ctgctgtacg atacttcgta ataaacacag ctattagtgc aattaataaa 3002461 aagaatacaa ctccgatgat cattataatc ggcattgtca tatcaaattc ctccttttat 3002521 gttaaatggg ttcatgcgga gtaaccgaaa gaactccgtt gttaatatct acgactaaca 3002581 ccgttgtccc gtaactgatc tgctgattat caaaactgac cgctgacttt gaaatggtcc 3002641 cgcctatccc ttctatgacc acttcaccaa acccgtcaac cggcacagct gtaatcactt 3002701 taccgagtct tcctctgaga tcatcttctc tatatgccaa tgattcttct gcagatgata 3002761 atggcaccag tacaaagatg tgaagcaata ccaccagcat gatcgaaagg atgcaagata 3002821 aaagcgcaat cagcaagctt gacagaggca atacaagttc acctatatat ccgcccgctg 3002881 aaaaacatgt aaaaaatgag agcactaatg tcggattaag aaacggaatg ccttctgaca 3002941 gccctgaaaa tacatctccg aaaaacagga ataacagcgt aaggctgccc gcaataataa 3003001 gcgtataaag atacattgtt tgtataggta ctccaaataa ctccaacttc ctcatccttt 3003061 cttcatcaat gcattgatga acggctgccg ttaccattta tacgagacac ctcgggaaaa 3003121 gtttcaaaat tttaagacaa ataacccatt tgaagtgctt tataaatgat aattgcttat 3003181 atatatggta atgtcatttt aggaggagat atgatgagta tctttaatga agccagatta 3003241 gaaacgtgga acgaattgaa aggactttct gacgaaaagc tgaatcaaaa gccttctgct 3003301 gaagaatgga gcatacggga agttcttgac catttgaaaa aaatcgatat gaccgcacaa 3003361 aaaatgttga aggaacgtgt aaaggacgct ccgattaaag aaattgaaga aaaaccgctt 3003421 gaagtagcac aggacagaaa taataaacgg aaagccccga gtcatcttga gcctgcgcat 3003481 gattttattt caggcagcca aatgaaacgt gagcttgatg tggtaagaga gcagctgact 3003541 gctgcgattg cctctctgaa agaagaagat tttgaaagag tgcttccgca tcctgtgttt 3003601 caagagctga ctgtcagaca gtggatcgat tttatcggcc atcatgaaaa acggcacctc 3003661 agccaaatga aagaaattaa agaaaagata gaaagggcct gatttaatca gaccctttct 3003721 gcttttcgtt tgacttttcg ctgataggaa tgaacttcta tttcatcacc tgtgtaaaca 3003781 gcaccaggtc tctccacaat acagacaatc cctctaatgc ccagtgcgtg gcggacgaaa 3003841 gccgacgcca gcttcggttg gtccggataa taagactgaa tgacttctcc cggctggata 3003901 cacggatcat tttcgccctc acacagcaga gccgctccgc tcggaaaaat aatccggctt 3003961 ccttctttta atgaagtaag atctggcata ccgctgactg ccacattcgc cccgagccat 3004021 tccggcaaaa ttctcggcac tcccattttt aaagcgattt cgttgcattc ctctattgaa 3004081 acaattgaaa tttgtctgcg gttgaaaatt tcagtccctc ttgaaaacat tggttctctg 3004141 gctcccgctt ttttggtcag gccaaaatgc aagtcgccgg ggatgccgcc ataatcaaaa 3004201 tcaagcttgt ccatttgctt tgttacgaag ctttttgtat ctgcgatata taagccttcc 3004261 gcttttgcag tcatacgctt ccacatcagc tggcaccttc cttcttatct aaaatttcca 3004321 cctatgcttc attatcccaa aaaatcccgc tctgtaaagg agcgggattt tgattatacc 3004381 gttttaggcg taaggttaaa gcagcgtttg tagatccagt tgtatgcttt ttcatttaaa 3004441 tctctagggt ttccgaaggt ttgcggatct ttcattgctt ctttagacaa gcgttcgatc 3004501 atatcaggtg atactccctg ctcttctaaa gtcggcactt ctaaatcttc gaccagatca 3004561 tacatccaat tgacagatgc tttcgcagct tcttctgttg tcatcttgct tgtatcaata 3004621 ccgaacgctt tcgcaatacg cgcaaacttc tcaggatagc ccttccagtt gtattccatg 3004681 acagggccca tcatcgccgc tacacattgg ccgtgagcga ctgggataat accgccaagc 3004741 gtttggctca tcgcatgagc agcgcccgct gattcacttc cgtaagaaag accggcaagc 3004801 atcgcagcct gcgccattcc gtaccttgct tccagatcct ctccatcagc aaatgccctc 3004861 ttgatgtaat gagcggcata ctcaatcgcc attaaggcaa ccgcatccgt gattggctgt 3004921 gcaaatttca ttgtatagca ctcaatggca tgggcgagcg catcaattcc cgtcatagct 3004981 gttacatgcg gaggcattga aacatgaagc tcaggatcaa tgattgtcaa gtgcgctgca 3005041 atcagcggac cgcccgtgtt gaatttgaat tctctttctt catctgtgat aaccgcccat 3005101 tgggttactt ctgatccggt tccagctgta gtgggaattg tcgtcagcgg aggaatgcgg 3005161 ttttccagcg gttttttccc atctgccgct tcataatcaa gcacgcttcc ttcgtgagtc 3005221 gcttctactc cgattgcttt tgctgtatcc atggagcttc cgcctccgac tgccaccaaa 3005281 ccattacagt tctctttttt gtaaagctca gatccttcat tcaccagacg gacaggcggg 3005341 tttggctcaa ctttattaaa gagtaccact tcaatgcctg cttctttaag tgattcgatt 3005401 acgggatcag caacaccggc tttataaatc ccagggtctg tgacaaggag cgcttttgaa 3005461 acgcccagtg cagctacttc ctcacccgta tgcttgatgg ctccgattcc atgcttaatc 3005521 acagtcggaa tttcaaatgt gtggaatttc tgcatgcttt ctaccttcat atttaatgtc 3005581 atcatcaatc tccccctctt atgaattaaa ccagttaacc gctgccggtt ttgtattgcg 3005641 gtatacatgt ttgacttctg tgtattcttc aaggcctatt tttccaagct cgcgtccgaa 3005701 cccggattgc ttatatccgc cccatggcgc ttgtgcaaag tacggatgaa aatcgttgat 3005761 ccaaacggtt cccattctca agcgggctgc tacccgttcg cacttttcaa tgtcttttga 3005821 ccataccgct ccagccaagc catagatggt atcattcgca agctcgatta cctcttcttc 3005881 agagctgaag gtttcgactg tcaatacagg accgaaaacc tcttcctgaa cgattctcat 3005941 gtcagaatta cagtttgaga aaatagtagg ttcatagaaa aagccgtttt gaagctcagg 3006001 atcttccggg cgtttgcctc ctgtctccag cttcgcgcct tcctctattc cgatctctac 3006061 atatttttct acctttgccc tgtgctccgc cgaaataagc ggaccgcttt ctgtctcagc 3006121 atgaaaaccg tttccgagtt ttatgcgttt tgcccgtttg accagctccg ccaaaaattg 3006181 atcatgaatg gcatcctcaa caagcaagcg ggaacctgca gagcatactt ggccggcgtg 3006241 gaaaaataca gcgtttaagg cctgatcaac cgcaacttct aaatccgcgt ccttgaaaac 3006301 aatatttggg tttttcccgc caagttcaag ggcgattttt ttgacgtttc cgcttgccgc 3006361 ccgcatgatt tttttgcctg tttcaattcc gcccgtaaat gaaatcaaat cgacgtcttt 3006421 gtttacggca agctcgtcgc ccactgtggc tcccggtcca agaacaagat ttgcgacacc 3006481 ttttggaaca ccggcttctt ccatcagctt aaagactttg attgtcgtca gcggcgtaat 3006541 ctcactcggc ttcatgacga ttgtgtttcc tgcggccagt gcaggggcga ttttccagct 3006601 cgcttgaagg agcggataat tccatggagt gatctggccg caaaccccga ttggctccct 3006661 aataattttg ctttctgaat caggaatcgg agatgaaatg atctctccgc catctttgtc 3006721 tgccaagccg gcgtaatatt gaaaaacatt ggcgatatcg tccatatcgg ccttgctttc 3006781 ttcgagtgtt tttcctgtat caagagattc aagctcagcc agctcctcaa gatcgcgtct 3006841 gattaattcc gcaattttca gaacaatttt tccgcgttca agcccggata gcgatgacca 3006901 ttctcctttg tcaaatgctc tacgtgcggc tgcgattgct ttgatggcgt cctctcgccc 3006961 tccctcgctt acagttgcaa tttcttcttg attaaatggg ttgataatac tgcggatctg 3007021 ttctttttcg gcactgatcc attctccgtc aatgaataat gtttgactca tataagcctc 3007081 cttgacgtaa ataaagtttg ttaaataaaa atttaatgtt tttaacaacc ttaatctaac 3007141 atatggtttt taaactgtca aagtcccatt ttgatttttc tttttgactt ttcctcatgt 3007201 ttcgttaaga taaagaacat aaagaaataa cttaacgaat ttaattttct aaaggaaaag 3007261 agggtcagta tggatgaaaa tccagaattt gcagctatag aacaggctcg ggatcttgtt 3007321 attgactcca ttgctgaaac gatggatctt tacggaatta cccgcagtgt cgggatttta 3007381 tatgggacga tgtatatgag ggatgagatg acgcttgacg aaatgcgtga ggagttgcaa 3007441 atgagcaaac caagcatgag cactggcgtc aaaaagcttc aagacttaaa tgtagtgaaa 3007501 aaaacatttc accggggcat ccgcaagcat acatttgtgg ctgagaagga tttctttaaa 3007561 tttttcacaa atttctttcc acctaaatgg gagcgggagg ttcaagtgaa tgtaacagcg 3007621 atcgaggaag ctcaagctga tttacaaaag gttttatgca aggaagatct cgatgaggat 3007681 atcaaaaatg aagcactgca gttatatgat cagctggaaa gctctaaagc ttactatgac 3007741 tggctgaaac ggcttgctga atcggtgcag accggagaaa tttttaaatt tataccggtc 3007801 gaaacaaagt aaagcagaaa acgcctggga aactaggcgt ttttttgatg taactactac 3007861 aaatttgaaa aatacgggaa aaacacccca tttacttcca aaatatttga tggtaatttt 3007921 atgtaggtaa aatttgtatt tggcctttca gaggaggtga aaagcgggca ggcctgttta 3007981 atttatcatt ttttaggggg aattttgtta tgaaacgcaa attattatct tctttggcaa 3008041 ttagtgcatt aagtctcggg ttactcgttt ctgcacctac agcttctttc gcggctgaat 3008101 ctacatcaac taaagctcat actgaatcca ctatgagaac acagtctaca gcttcattgt 3008161 tcgcaacaat cactggcgcc agcaaaacgg aatggtcttt ctcagatatc gaattgactt 3008221 accgtccaaa cacgcttctc agccttggcg ttatggagtt tacattgcca agcggattta 3008281 ctgcaaacac gaaagacaca ttgaacggaa atgccttgcg tacaacacag atcctcaata 3008341 acgggaaaac agtaagagtt cctttggcac ttgatttgtt aggagctggc gaattcaaat 3008401 taaaactgaa taacaaaaca cttcctgccg ctggtacata tactttccgt gcggagaata 3008461 aatcattaag catcggaaat aaattttacg cagaagccag cattgacgtg gctaagcgca 3008521 gcactcctcc gactcagcct tgcggttgca actaatgtaa aagaccggtt aacgccggtc 3008581 ttttttgcgt tttaccctcc cctttttctc taatccccgt tatctttttt ctggtttaaa 3008641 atttaaattg acaaacacta gaaacaggag taaattcttg agtgttcaat ttcatacagt 3008701 ctcttttacc gcttaatcaa acacgaacgg gggaaccaac gattggctgt tttattaaca 3008761 gccttggggt gaatcttact aagtaagagg gggtactctg aatccctaat ccgacagcta 3008821 acctcgtagg cgtatacaga gaggaggtct attatcggcc attctttgca atggtctttt 3008881 ttgtttcaaa aacgttaatt cactaaggga gatatgaaca ttgggaagaa ttaaaaataa 3008941 gcaatttgcc gtgatcgggc tgggccggtt tggcggcagc atttgtaaag aacttcatag 3009001 aatggggcat gaggtccttg cggttgatat caacgaagaa aaggtcaatg catatgcttc 3009061 ttacgccact catgcggtaa ttgccaacgc caccgaagaa aacgaattgc tttcattagg 3009121 aatacgcaat tttgaatatg tgattgttgc catcggagca aatattcaag cgagtacgct 3009181 gaccacccta ttattaaagg agcttgatat tccaaatatt tgggtgaagg ctcaaaacta 3009241 ttatcatcac aaggtgcttg aaaaaatagg cgctgaccgc attattcatc ctgaaaaaga 3009301 tatgggggtt aaaatcgcac aaagcctttc agacgaaaat gttttgaatt acattgatct 3009361 atctgatgaa tacagtattg tcgagctgct ggctacgcgc aagcttgatt caaaatcgat 3009421 tattgacctg aatgtaagag caaagtacgg ctgcacgatc ctggccatta aacatcatgg 3009481 agatatctgt ctttcccccg cgcctgaaga catcattcgc gagcaagatt gcctggtgat 3009541 catgggccac aaaaaggata ttaaacgttt tgaaaacgaa gggatgtaga caaaggtgac 3009601 acttcaaaag gataaagtga tcaaatgggt tcggtttaca ccgcctcaag tgcttgccat 3009661 tggttttttc cttaccatta tcatcggggc tgtcctatta atgcttccga tttccactac 3009721 gaagccattg tcatggatag atgccctttt tactgcggct tccgctacaa ctgttacagg 3009781 gcttgctgtt gtcgataccg gcactcaatt tacggtattc gggcaaacag taattatggg 3009841 gctgattcag attggcgggc ttggatttat gacatttgcg gtcttgatcg tcatgatatt 3009901 aggaaaaaaa atcggcttaa aagaacgaat gctcgtccag gaagccttaa accagccgac 3009961 aatcggcggt gtcattggcc ttgtcaaagt cctgtttctg ttttcgatca gtattgaatt 3010021 gatagcagca ctcattttat ccatccggct tgtacctcaa tacggctggt catccggctt 3010081 gtttgcaagt ttgtttcacg caatatctgc ttttaacaat gccgggtttt cgttgtggcc 3010141 tgataatttg atgagctacg ttggcgatcc tacagtgaac ctcgtgatta ctttcttatt 3010201 tattacagga gggatcggat ttacggttct gtttgatgtg atgaaaaatc ggcgttttaa 3010261 aactttttct ttacatacaa agctcatgct tacaggaacg ctgatgttga atgcgatcgc 3010321 tatgcttacg gtctttattt tagaatacag caaccccggc acgctcggcc acctgcatat 3010381 agtggataaa ctgtgggcct cctattttca ggcagtgacg ccgagaaccg cagggttcaa 3010441 ttctctagat tttggaagca tgagagaagg aacaattgta tttactttat tattgatgtt 3010501 tatcggagca ggaagcgcat caacggcgag cggcattaag ctgactacgt tcatcgtgat 3010561 tttaacatct gttattgctt acttgagagg taaaaaagaa acggttattt tccgccgttc 3010621 catcaaatat ccgattatca ttaaagcttt agctgtgagc gtcaccagtt tgttcatcgt 3010681 gtttttaggg attttcgccc tgacgatcac agaacaagcg ccatttcttc aaattgtgtt 3010741 tgaaaccttt tccgcattcg gaactgtcgg ccttacgatg gggcttactc ctgaactgac 3010801 aacagctggc aagtgtatca tcattgtcat catgtttatc ggaagaattg gtcctttaac 3010861 gttcgtgttt tcattcgcaa aaacagagca atcaaatatc cgttatcctg atggcgaagt 3010921 gtttacaggg tgatatcaaa aaaatccggc gtgcagtcgc cggatttttt atgattcgat 3010981 atgagattga ttttgtcttt tttcctgttc cgcgatgatt tcgttatcct ccgcgttatc 3011041 acgggtcact ttttgcgtaa gaatcgcacc aactgctaca agtatcataa cagcgatgta 3011101 ataacctttt tcattgagtt ccagattatc agcattatag agtccgatac taaacaaaaa 3011161 tactcccgca aaaaaagtaa aataagctag tactgtaaag gcaaccgtgt ttctgcgtct 3011221 atatttctgc acctttgttc cctcccgaaa gcatagttaa aaagtgataa cttccgtgga 3011281 atattatacc tcaaattccc cggaatggaa caaagaatta aaaataccag taaaaagggc 3011341 ttaggttgcc tcctttattt caacagctga atcatcaatc cagccgataa gtttatcatt 3011401 gatttggaat tggtaccata cagactggcc tttctgtttt ttagacacaa cctttatgtc 3011461 tttgccgacg taagattggg cagaggtaag ccttatggac cgatcatcag tagaaggctt 3011521 ggaccatacg tcttgaacgg cactgtcttt aatagaggcg tttaaatcca cagatttgag 3011581 ggatggattt acctcatcgt actcatctaa atcgtatttt tccacaatag cgctgatttt 3011641 gtcagcgtag tcagggtctg tagcatatcc tgatgtttgc agggcggttg ccgcttcctt 3011701 ataattccct gcctcaagca ccggtttata cttcttttta ttccacgatg tgccacggac 3011761 gaacaattgg gcgtgatcat ccatagattc aaaaaacgtg ctgtattttc gaaacttcgc 3011821 gcgaatggtt tttcttttcc ctttttcaac ttcgtccgtt tccatcgtga catgatggcc 3011881 tttataattc ccttttacgc caaaaaggtt gttggcctta gcagccagtt cactgttccc 3011941 ccagtccgat tcgagaatgg cctgagcaat tgtgatgctg gggagaacat ggtatttttc 3012001 atacaaaatt tgggcatgtc cggacagact gtctataaat acttgctgtt catcgatttc 3012061 ttcagtttct ttggatattt caatcggttt tgataaagtt gtcgctaaaa caaacagagc 3012121 tagcggaatc gatacaagga aaaatagtga aatcaagagt ttacgttttt taagtttttt 3012181 acgggccatg aaaaccttcc ttcgaattaa aagattacga atgtaaaaga atctaccttt 3012241 tagaatttta cttgcacttc taatattttt caattcttta gggataaagt tgggaaaaga 3012301 ttgcaaaata aaaacctttt cgctcaatga aaaggttttt accatgtttc tatttttgta 3012361 aatttctgag tgcattccga tattccgtat catttattac tttatatgat ttgacagttg 3012421 ccttcgacaa accttgtgct gagacggccg gtttttccgg agctgttttc gctttatcat 3012481 gtggtttatg tgccagcttg tgccccattc cagtggcatt catacaaaat gacaggcaga 3012541 cgagcagcac gctaaggata aaagaaatga agaagagatc atgataagca gtcatcatag 3012601 aatcctgtac cgaaccgctt tgtctggcag catctttttt cgtgaaaaag ccgatgagaa 3012661 tgggaactcc catatagaca aacaatctta aaaactgaac agctgtcatt ctcttgacca 3012721 aatcaggcag cgggcctccc atggcagctc ccatcagccc tgcggcgact gtcaggcctg 3012781 ttcccgctgc aagcatgata aacagtgccg cgaacatata aagagatgat cgatcctgta 3012841 tatgcagcca ttgaaaattc acaaaaacga gaatgagtcc gccgataata ccgagcatcc 3012901 ctggtccgac tttatcgtat aacagagcgc tcaaaatggc cgcgatcgcc actccgatta 3012961 aaagagtcaa gcttaaaaga atgagatgct cctgagaaat atcatacatt tgacggagca 3013021 agccttgaaa agcagaaagg ctgacagcta ccgttatcgt ccctgcagct atgatcaata 3013081 agccgagcac cggttttggc agcagcatca gtttaataga tatgaagggg tttttcactt 3013141 tatattccac aatcaataga ccaatgagca aacataacgt caccccgaaa ccaatccata 3013201 cataacccga tgacagcccc catttttgca gaaaaatgaa tgaaaccgct gaggctgcgg 3013261 caaggaagac agataaaaga attcccgcac gatcaagcgg ctgttcttga tccgccgctc 3013321 cgtgatgctc atcatgaaga aagaaatagc tcaccgcgac accgatcagg gacaaggtgc 3013381 caaagatgaa aaacagccat ctccaatgcc cgcagcttgt tgcaatggtt cccaggattg 3013441 taccgatgat aacagaacca tagaatcccc cgatcagcac aagcagtgca tagttcctgc 3013501 gttcaatcgg gaatgacagt acaagcattg gaatcataat catcagcatg acgcctgttg 3013561 ccgccccttg taaaaagcgc cctgccgcca tcaatgcaat atcgcctgaa catgcgatga 3013621 gcagtgagcc tagtataaag acaggtaatg aagccagata gacgggacga gcaccgaatt 3013681 ttttcctcag cagcggtcct gccggaacta acaaggcaaa ggccatattg ccgatcaata 3013741 tcggatttac tgatgtaaag acacttgttc caaccgtttt ctgaacaagg ccttgaactg 3013801 acgacaatgc cgtgttagac atcaatcccg gcccgaccgc taagacggcg agcaaagaaa 3013861 tcacccaata gtgttttgtc ttcatgttgt catcccttcc tatatgaata catgcgaaac 3013921 acatcatttt ttgaaaacaa aagaagctaa tagattttgc ataccattag ctttcattct 3013981 aatattctcc ctttcagggg aaatgatatt attttattat aattatgtga atgaatgagc 3014041 atataatcaa atattatttc aaatcgattg tgttttgtca atggagtaaa tttcaagcac 3014101 aacatagaaa gcttgaaagc ttttccccga tattgtgtct agaactgcac ttatgaatcc 3014161 ctgctcgttc cctcaagcga attaaagcag gccgttttaa tcctttcaat ccactattcc 3014221 aactaataaa ctcaaataag ttggtgataa gacaacattt tacccccaca tttttttgtg 3014281 ttcactgggc gtttgccgcc tctaaattgt atatgggtaa ataccatgaa ttaacctatg 3014341 aaataccaat gtaagggagg caaaaacgaa tggaactgta tgagtgtatc caagacattt 3014401 ttggcggctt gaaaaatcca tcggttaaag atttagcaac gtctttaaaa caaattccaa 3014461 acgcagcaaa attgagtcaa ccgtatatta aggaaccaga ccagtacgct tacggccgaa 3014521 atgccatcta tcgaaataat gaattggaaa ttatcgtgat taacattccg ccaaacaagg 3014581 agacaacagt acacgatcat ggtcaatcca ttggttgtgc aatggtgtta gaaggaaagc 3014641 ttcttaattc tatttatcgt tcaaccggcg aacacgcaga actctccaat tcatactttg 3014701 tccacgaagg agaatgcctt atttcaacca aaggtttaat tcacaaaatg tccaatccaa 3014761 catctgaacg aatggtgtct cttcatgtct actcccctcc tttggaagac atgacggtct 3014821 ttgaggaaca aaaggaggta ttggaaaatt catgattgac agataaactg ctcactttga 3014881 cttcactcaa ctggaggatt cagagaatga aaccttttcc tcaaaacaaa aaaaccctta 3014941 tcgaataagg gtttaaaggt atggagccaa gggggctcga acccctgacc tctacgctgc 3015001 cagcgtagcg ctctcccagc tgagctatgg ccccgtatgt aacgtcatgt ttattataga 3015061 tgattttatt ttgaaaaaca agctgtttcc tcttgaattg acagaaaaaa taaggctcgg 3015121 aaaagagcct tatttttcga cttacatcat gatcaaaagt aaaatcacac cgagaataat 3015181 tcgatagatt gcaaatggga caagtttgat tttgttaatc agccttaaga agaaacggac 3015241 gacaaacagt gcgaccacaa aggcacagat aaagccgacg atgaaaaacg gcatcagatc 3015301 cgaacttaag ctgtcccaat gcttcacgag gcttagaaag ctggctccca tcatgatcgg 3015361 catcgccata ataaacgtaa agtcggctgc agctcggtgg tttaatccga gaataacacc 3015421 gccggaaatg gttgaacccg aacgcgagaa accaggccaa agggaaagac attggaataa 3015481 gccgacggct atcgcctgtt tataggaaat gcggtcgagt gtgtctgtcg ctgttttccg 3015541 tttattgacc cagtcagcaa aaagcatgag gattgccccg gcaattaaac cgatggccac 3015601 agttttaacg gaaaataaat attcatcaat gtaatcttca aacaaaaagc cgagaacagc 3015661 tgcaggcacg agtccgacgg caatttgggc aatgcttaat ttatgtccct gctcctggtc 3015721 gcttgtaata ttttttttca agcccagtaa atttaaaatt cggtctttaa acacgatagc 3015781 tactgctaaa atggagccta gctgaataac caccttgaat gagttagcag cttcttctga 3015841 catcagatta cttgatttta gccagatgtc gtctactatg atcatatgtc ctgtcgaaga 3015901 aaccggcgcg tactctgtta atccttctac gattcctaaa atggcggcta caaacaattc 3015961 ccatagagtc atgattttga ttctccccat tagacattta tttttttaca taacgggagc 3016021 ttcccataaa tggaaagccc gtcttatata actataaacg aaaatcacac tttatgcccc 3016081 ggcgtatttt catttttttc ttcatcgtat aaatgtgact gcattttaaa ccagtcaaat 3016141 aaatgtgtcg taatgacttt ggcaaccgca tagccgggaa tcgcaagaat gattccaaca 3016201 acgccaaaca gcttgccggc tgttaacagc agaaaaataa tcgtaatcgg atggatgtga 3016261 aggttttttc ccataatttg cggagagatc agcttccctt caatcagctg aacaatcgtc 3016321 caaacgatca ccagcttaag cagcatgagc ggcgatgtca ctatggcaat gataatcgca 3016381 ggcgtaatgg caatcgttgg ccctaaatat ggaacgatgc ttgtgcaagc cgcaatgact 3016441 gcaagcaatg aagcataatc cagcccgata atcaaataac cgataaacag caaaaacccg 3016501 atacagaagc tgacaatgat ctggcctctg atataagagc ttaaccgatg attcatttcg 3016561 cttaagactg tatatgtctg ttctttcaat cgagtcggca caaacttcag tatgtagacc 3016621 ggtaattttc ttccgtcttt tagcaaataa aatagaataa acggaaccgt gacgatcgaa 3016681 atgataatct cagtcagtgc gccgataaaa ttcccaacac cggtaaaggt gctgttcacg 3016741 atcgtcgctg cctgatccga aacctttgta gcaagatcag atatattaat gttcatcgtt 3016801 tgctgggcct gattgacgaa gttgctgcca atcagctgtt tcgtctgatt ttctacgacg 3016861 tccacatatc tcgggatatt gtcaatcaaa ctcataattt gttcttttaa gaagggaatg 3016921 atcgacacga tcgtgatcgt gatcagcccg ataaccaata ggtatagcag caatatagaa 3016981 tagattcttc ttattcttct tctctccaga aaatcgacga ctgggtttaa cagataaaaa 3017041 acaatgcctg tcaaaataat cggaagtgat atcgttttga gcagaacaat aatcggggtg 3017101 aaaataaatg atgtttttgt aaatactaga atatttaaac caatcagcag cagcacaagc 3017161 aaaaataaaa caaacttatt atccaagaag aatcgcttga atctgccgct ccatgtttgc 3017221 aacgtctcca ctatcgttcc tccgtcatac atagtttaat taaattgtac actatcgtcc 3017281 ctataatgaa aaataaaaac cgttaattgc tggaaaagct ttctcggttt taacattcta 3017341 tttatatcta tcatgtgatt ttgttctttt taagctataa tttagctata tcatgcaaaa 3017401 ggagcgatac gagtgatacg ttttgcaata ataggaacca actggattac agaccgcttt 3017461 cttgagtcag cagcggatat cgaagatttt cagctgactg ctgtttattc aagatcggct 3017521 gaacgcgctg gcgagtttgc tgctaaacac aacgctgcgc atgccttctc agaccttcag 3017581 gaaatggcgg cgagcgattg ctttgatgcc gtatacatag cgagcccgaa cgctcttcac 3017641 aaggaacaag ccgttctctt tatgaaccat ggcaagcatg tgctttgtga gaagccgttt 3017701 gcttcgaata caaaagaaac agaagagatg atctcagcgg ctaaggcaaa cggcgttgtt 3017761 ctcatggaag caatgaagac cactttcctg ccgaatttca aagaactgaa aaaacacctg 3017821 cataaaatcg gcactgtccg cagatttacc gcaagctact gccagtattc ctcacgatat 3017881 gacgcgttca gaagcggaac tgttttgaat gcgtttcagc ctgagctttc caatgggtca 3017941 ttaatggata ttggcgtcta ttgtatttat ccggctgttg tgttgtttgg cgcgccgaag 3018001 gatgtaaaag caaacggata tgctttatcc tccggagtgg acggagaagg aactgtcatt 3018061 ctgtcttacg acgggttcga agctgttctg atgcattcca aaatctctac ttcctatgcc 3018121 ccggctgaaa tccagggtga agacgggacg attgtaatcg atacgattca ccggcctgaa 3018181 cgtgttgaaa tccgctaccg ggacggccgc cttgaaaaca tcgcgatccc tgatcctaaa 3018241 ccggcgatgt tctatgaagc agaagaattt gtcacgctta taaaagagaa taagctggaa 3018301 tctgaagaaa atacatttga acggtctttg accaccgcaa aaattatgga agaagcaaga 3018361 aagcaaatgg ggattgtata ccctgctgat caagcttaaa aaaatccgcc cgcgtgcaaa 3018421 tgccgcggcg gattttttat tagacaatcg gagaagatgc cttccttttt aaaagcacct 3018481 gttgctcata ttctttgatg tcataaagcc atgcctcttt taccggaacg cccatttgct 3018541 cacagtagga atcccagatg gctccgaaag gatatgtttt gaattcctcc atcagggcca 3018601 gcctttctgt atagcggccc tcttcctgca attgttttaa atatccgttc gggagaagca 3018661 gggcatacaa taaagctttg atcatatttc tcgttccgat ggtccaggcg gctacacggt 3018721 taatgctggc atcgaaaaaa tccagaccga tggctacctt ctcaagagca tgatttcgta 3018781 caatttcaag agcgatttct ctcaattcat catccaaaac cactacatgg tcgctatccc 3018841 aacgaacagg ccgcgatacg tgcaaggcaa gcttgtctgt gtaaagcagc atggacgaga 3018901 tcttgtttga taccgtctca gtcggatgga aatggcctgt atcaagtaaa caaagcttat 3018961 gattcgtcaa agcataagct aaataaaatt catgagatcc gacaacatat gattcggagc 3019021 caagcccgaa cagcttgctc tcgattgaat caagattatg ttgttcactg atctcctctg 3019081 agaagatccg atccagtgat tcttttagtc ttttacgcgg tgtcagccta tcactcggga 3019141 tatccttata gccgtcggga atccaaatat tcgtcaagca aggtgttcct aattctttcc 3019201 cgaagtattc cccgatacgg cggcaagcga tgcaatgcct gatccaaaat tctctgatgt 3019261 ccggatcagg gtgtgaaagg gtgagtccgt cagccgcttt ctcatgcgaa aacaaggttg 3019321 gattaaaatc taaaccgaga ccaaggtttt ttgcccattt cacccagttt tcaaaatgct 3019381 gcggcttcaa ttcgtcacgt tctaccgctt ccctgtttgt ttctgcgtat atcgcatgca 3019441 ggtttacgcg gtgctttcca ggaatgagag aaagagcctt ctccaaatct cttcttaatt 3019501 cttcaggagt ttgcgctttt ccgggataat tgccggtcac gtcaattccg cctgaaagct 3019561 cgcccttatt tacttcaaag ccttcaatgt cgtcaccctg ccagcagtgg atcgaaatgg 3019621 gcacttgctc taattgccga agcgcctctt caacatcaat tccccatttt tcatatgcct 3019681 gttttgcact gtcataattg gcttttatgg tcatacggct ctctcccttt atcagttttt 3019741 caatccaaat aaaaaacttc ctttagatct atcgcaacag gactgaaatc cgaatttgtt 3019801 ttcattaatg gcgccatcga tttccaccat ctttggcaaa cttccgtgtc cgccatcttt 3019861 ctccatttct cttcatcctc tatttctaaa tatgcaaaaa gcctgcctgt ttcctcgtct 3019921 agaaaaatgg aataatggtg tgctccatga gctttgagtg cttctgccat ctcaggccaa 3019981 atgtcatcat gccgctgttt gtattcttcg tacttgtctt gatggacaaa catgatactg 3020041 gcttttcttt tcaaaccttt tcacctcttc atcatttaga tagcgctttc aaaacagttt 3020101 gctgaaatga ctgaatgatc gtgcttctat caatgtcttt aggtgtaaac actttgatcg 3020161 gaaaggaatt tctgacgact tgccgggctt cttttatgtc tttgacttct ttggcagcaa 3020221 tcatttgcat caaaagattt ccggtggcag ttgcctctat cggccctgca tataccgctt 3020281 ttccactcat gtctgccgtt aattgattta agaaatcatt ccgggctccg ccgccgatga 3020341 tatgaaattg ctcgatcggt ttttctgtga ttgtttcgag ctctttgatg gctatcgcat 3020401 agatgatggc taaattgctg tagatgcagc aggcaagttc gcctgcagta cggggaatct 3020461 tttggcgggt ttgtctgcaa taatgttgta tttcctttat catgttttct ggattcagga 3020521 aacgtttatc atttaagttt ataaattgct ggaatggttc tgtttttttg gcttcttctg 3020581 caagctgctg aaaagaataa tctgcttgta gctgctgttt gacttcttgt atcacccaca 3020641 tgccgataat gtttttgaga aagcgaatgg tgttgtttgc gccgcgttca tttgtatagt 3020701 tgttttctaa agcaagatca gttattatcg gtgttttgtt ttcaaccccg attaacgacc 3020761 atgttccgct gctgatatac gcccagccat catttacgcc tggcgccgca atgacggccg 3020821 aggccgtatc atgtgttgcg actgtcatca ccttgcacgc cgggagatca taatccggga 3020881 accactcatt tcttagcttc ccgagttcac accccggttc agtgagcggc gcaaattgct 3020941 gttccagaac agacacggct tcaagcaatt caggatcaag atttcccgtt gagacgttta 3021001 aaagctgtgt tgtggacacg tttgtgattt ccgttacagc ttttccggtt aaacaatagc 3021061 ctaaataatc aggaatcatc ataattttgt ctgtcttttt cagcagctca cggtcttctt 3021121 caaacaattg atagatcgtg ttgaaaggct gaaattgtat tcctgttttt tgataaattg 3021181 cggcttttga gagggtatgt tccagtttgt ctattgtgtg atctgttctt ctatcacggt 3021241 aggagattgc ttcccgcaac cgatcgcctt tttcgtccag taagacataa tcgactgccc 3021301 atgtatcaat gcctacggtg cagtgttcat acccaagcgt ctttactttt tgcagtcctt 3021361 gcaggatttg ttttagcaaa tgatcaatat cccataagca atgcccgtct ctttgactga 3021421 aaccgttagc gaacctgtga atctcttgta tgtcaagctt cccttcattc agttcaccta 3021481 ccatgattct cccgcttgat gcgcctacat caatggcagt ataaatcatc ctttcaccct 3021541 ctcttcgaaa gaggaacagc tgtcaccttc acctttttgt cctcaagagc ttttaccgat 3021601 gccggatcaa gtccagaatc cgtaataagg cggctgacat cttgcagcga ggcgatatgt 3021661 gaaaactcgc ggttccccca tttgcttgaa tcggccatca aaatggtctg gtccgacctt 3021721 tcgatcatcc gttttttgag cagcgcctgc cactcatttg aatcactcat cccgttgtgt 3021781 acgtcaaatc ccttacatga cagaaaggtt ttattgacat gataggtctc aagtgaacgc 3021841 tctgctaacg ggccggcaaa tgataatgat ttttccagca aaatgccgcc tgttgaaatg 3021901 actgatatgt tttctttatt gctgagttca atagctgctt tcattgagtt tgtaatcacg 3021961 gtgagctcaa tgtcagggag tatttttgcc atgtaccaag cggttgtgct tgcatcgaga 3022021 atgattcggt ctccgctttt tacatatttg gccgcttcgt gagcgatggc ttttttttcg 3022081 atgacattcg tgatttcccg ttcagaaaaa tgaatttctg attccttctg ctgaatactg 3022141 accgctcctc cgtggctccg gctcagttta tgttcttttt caagcttttc aagatcacgc 3022201 cgaatggttt cctctgtgac tgaaaaaatg tcacttaatt cggaaacgcg gatgcttgaa 3022261 cgcatattta ctatttccac tattttttgc tgccgttctg ctactagcat cggtaacgcc 3022321 cttcctcata tcgtagtccg tcttatattt ttatcatagc atatatctaa cgcgtaaaag 3022381 cagcagggac gccgccgtct accgtgatca tgcagcccgt tgttttttcg gctttggaag 3022441 aagcgaagaa tgcaatggct tcggcaatat cctccgggta aatattgacg agcaatgctg 3022501 tccgtttccg gtaatgttcc tccagctgat ccggttcaat cccgtacgcc gcggctcgtt 3022561 cctcacgcca gcttgaaccc cagattgccg atccttgaag aactgcatca ggcaaaacgg 3022621 agttgaccct aatgccgaat tctccgcctt ctgctgcgat gcatcttgct aaatgggttt 3022681 caagcgcctt aacagagctg taggcagagg cgttttttcc cgcataaact gaatttttcg 3022741 atccgacaaa taccatgctt ccgcctctat tttgatgttt catctgttta aacgcttcac 3022801 gggctacaag gaaatagcct gttcctaaaa cattcatatt aagattccat tcttttagac 3022861 ttgtttcgtc aaatgggctt gatgtggcca gcccggcatt attgacgacg atatcaatgc 3022921 cgccgtaagc aagcgccgct cgttcaaaag ctgactgtac gtcttcctcc tttgtcacat 3022981 ccattttgac agccattgcc cgtccttttc cgtatgcatc gtttatttcc ccggcaattt 3023041 tctgtgcgcc ttctatattc agatcagcta cgatcacgtg ccctccctca gctgcaaatc 3023101 ggcggcatgc cgcactgccg attccgccgg ctcctccagt tatcagcgct acttttcggg 3023161 aaaattctgc ttccggcggg gccagcgtga gtttatatag ttcgagcggc caatattcga 3023221 catggtagga ctcattttca tgtaaagaaa caaattgccc cagagcggtt gctcctttca 3023281 ttacggcgat ggccctccga tataaagccc cgcttacttt agacatcgca taactttttc 3023341 ctgtattcac cattccgatt ccaggaatca atatcacccg cggggcggat tcaaagattt 3023401 gatccccatc ctgctgattg cgtgtaaagt aagcctgata ctctgatgta aaggtctcga 3023461 ctcctgactt gatcagatct gcaagcttgt gcacatcttg agtttccgga ttccaatcaa 3023521 tgtacagcgg aacccgtttt gtgtgaacaa ggtgatccgg gcatgccgca ccgatttgcg 3023581 aaagtgctgg cgcttggaca ctgtttacaa attccaagac atcgtcatga tcatcatagg 3023641 aaaggatcat tttcttttct tcacttactg ctcctctgat cacaggcatg atgcctgcca 3023701 agatttgttt tcttttatcc tccggcagcg gctgatacct tttgcctccg aatacctcat 3023761 gctgattgat acgatcgtta atatactgct cggcttcttg aatgatggat atcgtttttt 3023821 gataacatgt ttcagacgtc tctccccaag tgactaagcc gtgtttctcc attaatacaa 3023881 gctcggcgtg ggggttgttt gctacgcctt cagcgatcat tttagacaaa gtaaatccag 3023941 gacggacgta tggcacccat acaaaccgat ttccgtaaat gtcttcagcg atttgttttc 3024001 cattatccgc acagcatatg ctgataatcg catctggatg ggtatggtca acatgtttgt 3024061 atggcagaaa agcgtgtaat agcgtttcaa ttgaagggcg gggatgtttg ctgtctatca 3024121 tacaatgaga caggtagtct accatttctt catcgggcat ttggtccctt ttaatcagcg 3024181 ggcggatatc atctaatttc aaaccggaaa agttatgcgc tttcattgtt gccaaatccg 3024241 atccgcttcc ttttacccac atgacttcta tttcacggcc tctaaaatcc ttttccgttg 3024301 ttttcataga tgtattcccc ccgccccagt tgcagacagt gcggtctgac ccgatcagat 3024361 tggacctgta caccaattcc tctacacctt taggtagctg tgcagctcgc tctgaatccc 3024421 atatatgttt caccatattt gatattcctc catacccttt tatttgtatc cgttttcatt 3024481 atatatgatt tctgtttgtt tttgaatcgt ttttgtttat ttttgctttt taacaaaaaa 3024541 agaaagcagc agatatgccg ctttctcgtt tcattatgat tctattttaa atttcttcgt 3024601 aatgtcctga agttcttccg ccatgtttgc caacgtttcc gctgaagagc tgatttcttc 3024661 catggacgca agctgttctt ccgccgaagc tgcgatatcc tgaatgcctg ctgagctttc 3024721 tttcgccact gcagaaatat cttcaacagc acttgacact tcctgtgatc cggctgacag 3024781 ttgttcaacc gtcgcgttca agttttgcaa ttcgccggaa atttgggttg tcatctcata 3024841 gatttgttta aagctttccg ctgtttgatc cgtaatctgc aagccttctt tcacttcatg 3024901 attcacggat tggaacattg aaagtgaggt gctgatttcc ctgacaatct cttgaattaa 3024961 tccttcaatt tccttggcgg agtctgctga ttgtacagca agttttctaa cctcttccgc 3025021 aactactgag aaacctcttc cgtattctcc cgctcttgcc gcctcaatcg cagcatttaa 3025081 tgcaagcagg ttggtttgat cagcaatgcc gttaatcaca ttcaagatgc ttgtgatgtc 3025141 ttgcgatttt gtttcaaggc ccttcacaac cgcttccgct ttttgaacgg attggtcaat 3025201 tgttttcatc tggccgactg tatgctccac cagcttttct ccgctgcccg ctgcctcaga 3025261 ggactgaatc gatgatttcg taatggttga agaggcttga gccacttttg aaatcccctc 3025321 gttcatttga gaaagatgat ttgagcttgt ttccagtttc tcgctttgtg cctcgttgcc 3025381 atctgagaac tgttcgatgg caagtgtaat atgttcagtt gccttgcttg tttgggctgc 3025441 gcttgctgtc agctcctcag aagatgaagc gacgttttct acagacgttt gaataacgcc 3025501 tattacagaa cgcaatgatg cagacatttc attaaagctt tcgccaagct ggccaaactc 3025561 gtttttcgag tgaatgtcaa tgacttctgt gagatctccg ctgctgattt ttgcagacgt 3025621 tgagacaagt tttcttaacg gcttggtgat ggcacggata atatagagta tgagtatgcc 3025681 gccgattact attgacacgc atagaatgat aaccgcagtg ttcagcaccg ggcttgaagc 3025741 atcttgcaat tcactgacaa aatatgtgcc cgcgattttc cagccagtca gtttatttgt 3025801 cgtaaaggcc attttctttt ctttgccttc gaatgtatat tcaaatgagc cttctttttt 3025861 ggaatatact tggtttgtcc aatcgccgga accggttgtc cccggcttaa tggtcggatg 3025921 ggcgatatat tttttgttgc ctgtcgtaat aaatgcaaag ccttcttttc cgattttgat 3025981 tctttttgat gcagtaagca cttcatccag gtttaaatct agcgctataa cccctgaacc 3026041 gtcttttaat tgttttgaaa ttgtgacaac gatatctcct gtcgcttcat cggtatacgg 3026101 ttctgagaaa acagcttgtc ctttttccgc aaccgcctgt ttgtaccagt cacgtcctgt 3026161 cggatcgaaa cctttcggaa caccgctatc cggatattta taaagcttct tatcttctga 3026221 ggcagcatag attgcgccta catcgtcgtt aagtgtcgtg tactgcttaa atttctcttt 3026281 cagtaatgtt ttgtttttgc ctaacaatat gtctttatcg actgtctcac tataataatc 3026341 tattgctttt actttatctt ctaatttatt ttgcagcgta ctgtttagtt cttcaacatt 3026401 tcccttcgca ctgcttatga gctctctgtc taacgcgttc caagctgatt gataactgaa 3026461 atatgctaaa accccaaccg gcaaaataag cactgccaga aacgcagcga ttagcggttt 3026521 gctgatcgat ggctgtttga tccattgtat gaattttccc attctcgttg actcctcctt 3026581 taagataaat ctaatatcgt caaactagga taaaaggttt aataaaaaaa ctaaaaaaaa 3026641 cacccaagcg caacaagctt gggtgttaag gcttattatt caattttaaa tcgtttggtc 3026701 atatcccgaa gctcttccgc catagaggaa agggtctctg cagacgagct gatttcttcc 3026761 atggaagcta gctgctcttc agctgacgcc gcgatatctt gtatatgcgc tgagctttct 3026821 tttgaaatcg atgcaatgtg ctcagacgct cccgaaactt cttcggagct ggcagaaagc 3026881 tgctgaaccg tcgcactcat attttgcagt tcgccggcga tttggttcgt catttcagaa 3026941 atgcgtttga agctcatttc tgttttatct gtgatgtcaa gtcctgtctg cacctcttga 3027001 ttgacagatt ggaacatgcc gagtgatgta ttgatttcct tcacaatttc gatgattaat 3027061 ccttcaatct cttttgctga atctgctgac tgtactgcca gttttcttac ttcttccgct 3027121 acaacggaga agccgcggcc gtactcgcct gcgcgcgctg cttcaattgc tgcgtttaag 3027181 gcaagcaggt tcgtctggtc tgcgatgccg ttgatcacac gcaaaatgtt tgtaatatct 3027241 ttcgatttcg tttccaatcc gcgtacgact tgctccgctt ctttaacgga cttgtcaatg 3027301 acattcattt ggccgacggt ttgatgaaca agcttgccgc cttcacttgc aatttctgtc 3027361 gattgaacag atgaatcagt gatcacttca gaagcttgag ccatattcgt caacccgtca 3027421 ttcatttgat aaatgtgctc tgctgccgtt tcaatgtttt cgttttgttt ttcattgccg 3027481 ttagaaaatt gttcaatcgc caatgtaatg tgctctgttg ccttgctcgt ttgcgcagct 3027541 gatgcagtca gctcctcaga ggaagcggca acattgtcta ccgaatcctg gatggcgtgt 3027601 atgagagaac gaagtgacga cgccatattg ttaaagcttt tgccgagctc gcccaattca 3027661 tcttttgaac ggatatcaat ggtttccgtc aaatctccct cgctgatccg cttagaggaa 3027721 ccgacaagct gtttcagcgg tgttgtaatc gaccgaatga tcaatgtcat gacgataatc 3027781 cctatgataa tagctgcggc caagacaatt aaagcaaggt gaaggacagg ctgggctgcc 3027841 tcatggattt catccaaata catggtgccg ccgatcttcc atcccgtcaa cttgtttgtg 3027901 tcaaaggcca tttttttctt atcgccatcc atggtgtatt gaaaatcgcc tttatcagca 3027961 ctcaacatct tatcgagcca gtcgcctttt aattcagttc ctgattgttc attagggtgt 3028021 gcgacaactt ttttgtcctt cgtcatgata aatgcgtagc cttgtgtgcc gatgttgact 3028081 tttttggttg ttttcagcag attttcaatc gtcatgttga ttgcgataac gcctgaacca 3028141 tcttttgtct gctgggcgat tgtcacaacc atcgtatttg tcgacgcggt tttataaggg 3028201 tctgtgatca cgactttccc tttatttgca accgcttttt tgtaccagtc gcgttcaacc 3028261 ggattatagc cgcttggcat cggaagatcc ggatagcggg taaagtgccc ttttgtgtca 3028321 cttgtataaa tggattctac atccttgtta atgctgatat attgtgagaa tttctctgca 3028381 atgcttgcat tgctttttgc attgtatttc tcttttgtca gccattcgct gaaataatca 3028441 gcactgtttt ctttttcgcc gatgctggtg ttaatgattt cgtttaattg ctgtacattt 3028501 tccaatgcgc tccccatcat ctgtctgtcg agtgagctgc tagccgattg atacgcaaag 3028561 atcgccaata tgacaaccgg tatgatgagg atcgacagaa aggaaacgag aagcttccgt 3028621 gtaattgatc tttgttttat gagttggagt atttttttca tcattcattt ctcctttttt 3028681 atgctaccct tcatatcggc tggaaatggg taaatatata cagcaaaaaa gaagaaattt 3028741 aacaaaagta actaatttcc cataaataaa tagtatttta gacctattat ttgtctactt 3028801 taaattgttt tgtcagatca cggagttctt cagacattct ttcaagcgtc agtgcagatg 3028861 aactaatctc ctccatggat gccagctgtt cctcagctga agcggcgata tcttggatgc 3028921 catccgagct ttccttagaa atggcagtga tatcatttga agctgcggaa atttcttgag 3028981 ctcccgctga cagctcctca accgtcgcat tcatgttttg cagctcggaa gcaatttgat 3029041 tggtcatttg cgatatatgt ttgaagctct gtttagtttc atccgtcatg acaagccctg 3029101 tttcaacttc tttgtttacg gactgaagca cgttcagtga tgtgtgaatt tcttttacta 3029161 tttcactgat cagcgattca atttcttttg ctgagtcagc cgactgtacc gcgagctttc 3029221 tcacttcctc agcgacgact gagaagcccc ggccgtattc acccgctctg gcagcttcaa 3029281 tggcggcatt taaagccaaa agattggttt gatccgcaat gccgttgatg acacgcaaaa 3029341 tattcgtgat atcctttgat ttgatctcca gccctttcac cacttgttcc gctgctttta 3029401 cggaatggtc aattgtgttc atttggccgg ctgttttctg gacgagtgtc tcccctttgc 3029461 ttgacacttc ggttgaatct gcggatgttt ctgtaatcac tgctgcagcc cgcgccagct 3029521 ctgccaatcc gtcattcatt tcattaattt gttcggttgt cgtttctatt ttctcgcttt 3029581 ggctttcact gccgtttgaa aattgctcga tagccatcgt aatgtgctca gtggctctgc 3029641 ttgtctggtc tgccgatgca gtcagctctt cagacgagga ggcaacgtgt tctactgagt 3029701 ctttgatccc gtgaatgagc gagcgaagcg agtgtgccat atgattgaag ctctcactca 3029761 gaacgccgag ttcatctttt gaattgattt caatcgtttc ggttagatcg ccttcactaa 3029821 ttttttcagc ggatgcgaca atgcgtctca atggctttgt gatggatcga atcacaaaat 3029881 aaatcgccgt cattccagct ccgatggcaa tcgccagaac gattgaagcc atgatcagaa 3029941 ccctgcttgc agcatcgtga atctcgtttg catacatcgt gccgctgatt ttccagcctg 3030001 ttgtttggct tgttgcaaat gccatttttt tctttttgcc tttgtacgta tattcaaagt 3030061 ccccgctttt atccttgtag agcttatcaa cccagtcccc ttttagctct gttcccgctt 3030121 tttctccgga gtaggcgatg actttcttgt tttggctcaa aataaaagca tagccttctt 3030181 ttccgatatt gattcctttc gcggtagtga ctaagtcatc aattttcata tcaatggcga 3030241 caacgcctga cccatccacc gtttgacggg cgatggtgac gaccattttt cctgatgaaa 3030301 tcgattcata aggctcagtg acaattgttt tgcctttatt ggccattgct tctttgtacc 3030361 aatctcgttc caaagcatta aagtcgcttg gcatgtcagc gtacggataa cgtgtgaagt 3030421 ccccgtcttt gccgcttgaa aataccgcag cgacattatc attcatttgg ataaattgtt 3030481 taaattcctg tttcagctct gttttctttt tatcctgaaa tttttctgct gtagcccaat 3030541 cgctgaaata tgcgaggctt ttttcagtag tgctgatttt atcatcaatg atgtgatcta 3030601 atatctgaac attttccttt gcgctttgcg tcatctgtac atcaagtgag gcaactgctg 3030661 attgataagc gctaaccgaa agggcggtta tcggaacaat taagatcagc aggaaagaaa 3030721 taataagtct ccttgcaatt gatgatctgc gaatagtggt gagtgttttt ttcatttcct 3030781 tttgaacctt ctttcaataa tttacaaatt atatcggcgg atcttccttt aaattacatt 3030841 gaaaatggag gaaaaaatga aaaatagttc taaattcacc tgttaaacta ggactttatt 3030901 attgtttacc atataaaaaa acagcgcttt gatagcgctg tttttcggtt tttactcgat 3030961 tttaaattgt ttcgtcagat cgcgaagctc ttctgccatc tgcgcaagag tcgtcgctga 3031021 ggaactgatt tcttccatgg aagcaagctg ttcttcagct gatgcggcaa tgtcctggat 3031081 gcttgccgag ctttctttcg acacgtctgc aatgccgctg actgctgctg aaacatgctg 3031141 tgaacggtct gacagctgct cgacggtgga attcatcgtc tgcagcttgc ccgcgatttc 3031201 gtttgtcatg ctgaaaatgc tctggaagct ttcttttgta ttgtctgtga caacaagtcc 3031261 ggactgtact tcctgattga cctctttaaa catgtgaaga gaggtgtcga tttctgcgac 3031321 gatttcttgg atcagctttt cgatttcttt cgctgaatcg gctgattgga cagccagctt 3031381 gcgcacctcc tccgctacga cagagaagcc gcgtcctgac tctccggcac gcgccgcttc 3031441 aatggctgca tttagtgcaa gcagatttgt ttggtcagcg attccgttga tgactctcaa 3031501 aatgcttgtg atgtcttttg attttccttc taagcctttg acaacagctt cagcctgctg 3031561 aacagattga ttaatcgagt tcatttgtcc gactgtctgc tgcacaaact tctcacccgt 3031621 tccggcgatt tccgttgatt ggatagatgc ctttgtaata tctgacgatg tttgtgagac 3031681 ttgctggagt ccttcattca ttaagttcag ctgatgagag ctggattcaa ccttttcgct 3031741 ttgctcctcg tttccgtttg agaactgctc aatcgccatc gtaatatgct cggtggcttt 3031801 actcgtctgc ccggcagatg cggtaagctg ttcggaagat gcggccacat tgttcaccga 3031861 gtcctgaata gcgctgatca gagagcggag agattgtccc atttcattga agctttcccc 3031921 aagctctcca agctcatcct ttgaatggat ttcgatcgtt tcggtcagat cccccctgct 3031981 gatcgttttc gatgattgaa caagacgttt taacggtttt gtaatcgaac gaacgataaa 3032041 cagaattaaa attccgcctg ccacaatgga agcaatcagc acaatcattc ctgttgtcag 3032101 cacagacttt gaggcatcct taatttcatc catatacatt gtgccggcta ttttccaacc 3032161 agtcagttcg tttgtagtat aggtcatctt tttatcttcg ttattaagag tatactggag 3032221 ttcaccgctg tcattcgcat acattttggc tacccagtcg cctgaaagct tttctccagc 3032281 cttatggttc ttgtgggcga cataggtttt gttttttgtt gcaatgaaag cataaccttc 3032341 ttttccgacc ttgatttgtt tcatttgttc taacaattta tcaatggtaa tatccatggc 3032401 gacaacgcca gatccgtcct tcagctcctg tgcaatggta atgaccatgc ttccgtcact 3032461 cgcagccacg taaggatctg tcacgacaat ttcaccgccg gccttcatcg catcctggta 3032521 ccaaggccgt tgtctcgggt cgtatccttc cggcaatttt tcttttggcg cttgtacata 3032581 agtgccgtta tctgcgcccc cataaattct ggctactcct tgattaatag atacatattg 3032641 tgaaaattta gctttgatct cttcttgatt tgatttccct ttgaatgcgg atcttttaag 3032701 agattcactg aaaaaggtga ctgctttcgc tttttctccc agatcatttg taacagttgt 3032761 attaaatgta tcgacactgt ttttcgcatt tcccataatt tcctgatcca gctttccgct 3032821 ggcgcttcgg taagagctaa attctaatat aagaataggg ataatgagaa tcgcaataaa 3032881 tgagacgatt aatttctttg aaatagacgg tttcttcagc caattgataa aagtcttcat 3032941 gtcacttgct ccttcaggtt tgatacagta tatatcggct gcttaaaaaa gttttaaaat 3033001 aaaaaatgga agaagttctt tttggctgtc ttctgccttt ttaactttca ttgcccaagc 3033061 tctttgcata tcttataaaa aacaaggggg gctaaacatg attattgtat caggacaatt 3033121 gctccgtccc caggatattg aaaattggca gattgatcaa gatctgaatc cgctcttaaa 3033181 agagatgatt gagacgcctg ttcagtttga ttatcattca attgctgaac tgatgtttga 3033241 gcttaaactg cggatgaata ttgtagcagc ggcaaagacg ctgcacaaaa gcggggcgaa 3033301 gtttgccact tttttaaaaa catacgggaa tacaacgtat tggagggttt caccggaggg 3033361 cgccttggag ctgaaataca gaatgccgcc ttcaaaagcg attcgggaca ttgcagagaa 3033421 cggcccgttt tatgcgtttg aatgcgcaac cgcaatcgtt atcatttatt acttggcctt 3033481 aatcgataca atcggagaag ataaattcaa tgccagcttt gacagaatta ttttatatga 3033541 ctggcattat gagaaattgc cgatatatac ggaaacagga caccactttt tccttggaga 3033601 ttgtttgtat tttaagaatc ctgaatttga tccgcaaaag gcgcaatgga gaggcgaaaa 3033661 tgtgatacta ctgggggaag ataaatattt tgcccatggt cttggaatct taaacggaaa 3033721 gcaaattatt gataagctga attcttttag gaaaaaagga gccttacagt cagcctacct 3033781 tctgtctcag gcgaccagac tggatgttcc gtctcttttc cgcatcgtcc gctaaaaagc 3033841 cccatcgcct attttccgga cgatggggtt tcaaatgcct ttcgttttcg atagaagggg 3033901 gctgtgccaa aatattggtt cgcagcccac tccatttttt caaggtcatt tcttgtcacg 3033961 attggatcct ggctgctcca tttgataaag cggacaaaat agtagccttt gataggaacc 3034021 attgtaactt ttgagtgagg ccagccttca aatacaaact caattttccc tcttttttta 3034081 taagaatatt gaagaatgtt catatctgtc acctcagttt atcaagttac gttcggcaaa 3034141 gctcggtacg tttacatcca ttgattaact atccctcatg caggctttcc ggaaaacaaa 3034201 gggtgaggcg cgtgtctctt tccctcgctt tttatttcgc atatggacga atgccaagca 3034261 cgccttcatt cgataaagcc gcagcgtggg cgggtgtgac aagccctccg gctatcggcg 3034321 cttgttcagc gatcatgctt ttgtcataaa aaacagccta ttatcccatc attttgatat 3034381 agcatgtccg ggtgcgaggc ccgtcaaatt cgcagaaata aatgccctgc cacgttccaa 3034441 gaataagccg gccgttttcc acaatgacat gctgtgaagc tccgaccgta ctcgacttca 3034501 tgtgtgcagc tgtattgccc tccatatggc ggtccagctc atgttcccac ggatatacct 3034561 catcaaacct tctgagcata tcttttttga cgtccggatc ggcattttca ttaattgtaa 3034621 tgcccgcagt cgtatgcgga cagtaaatca gcgctgcgcc gctcgttata cctgtttctt 3034681 gaagaaacgc ttccacctcc cgggtgatat ctatcatttc atctcgtttg gttgttttga 3034741 tttgcagtgt tttcagcatt tgtttctcct ttcgtttgtc cgctctcatc gcttaattcg 3034801 ttctgtgttc ttttttttcc tgttaaaccg ctctcataaa cccgataaaa caaaaaaact 3034861 ccagtctaag gctggagttt agcaccatag atatattctt gcttcatacg gctttaagag 3034921 tactgatgtc atatgcttgt gcggctctgt ttcaatattt gacaagacga gtgcatctga 3034981 tgacaatggc aatccagagt gcctgaacaa cgccggtgtt cctgtcagat tggccgcaat 3035041 cagtgcagta tggctctcgt ttttccgaag atatgcaaag atttgctgat cttccggtaa 3035101 aatgagctcg tatgtcccgt taataaaaac atcatatgtt tggcgcagct tgatcaagct 3035161 tttgtaaaaa tggtaaacgg atgttttatc gtttttttgc gcctcggcat tcagccattt 3035221 gtaattctca ttgattccga tccacggttt ggcctcagaa aatccggcgt atggaccagc 3035281 attccattgc atcggcgttc gcgaattgtc tcttcccttt ttccagacaa tcttcatcac 3035341 atcctcgtgt gatgtgcctt tcgctgtttt tgtttcatac aggcgtttca atgcgacatc 3035401 atcatagtcc tcaatagatg gaaaagccac gttcgtcatc ccgagttcct gtccctgata 3035461 aataaacggt gtgcctttca tgagaaaata aacagcggaa agcgcttttg cactttcttt 3035521 caggtacact ccgtcgtctc cccacacaga aactgaacgg ggctggtcgt gattctccat 3035581 aaacaaagca ttccagccga tcccttccag actgtcctgc cagtcagtta aaattcgttt 3035641 aaatgcaacg atatcaatac tttcattgat ctctacatcc cacaggccga gatgctcaaa 3035701 ttgaaaaatc atgctgaata tgccgttttt ttctccagcc caatcagctg cttcttttgc 3035761 agcgacgccg tttgcttcac caactgtcat aatcggatag cgggaaaatg tgttttcctt 3035821 cagctctgtt aacaaatcca taatgccgtc agcattcata tgataaggaa aggaagggac 3035881 atagtccagt ccctttggat tcggcatgtc aggaaaccct tcttttttct taatatgcgt 3035941 aatggcatcc acccgaaatc cgtcaattcc tttatcaagc caccaattga tcatgtcata 3036001 aacggcattc ctcacctttt cattttccca attcaaatca ggctgttttt tatcaaaaag 3036061 gtgcagataa tactggcttg tcttttgatc atactcccaa gccggcccgc cgaaaatgct 3036121 ttcccaattg ttgggcgttt ttccgttttt gccgtctttc caaatatacc agtcgcgctt 3036181 ttccgagtgt atggatgaac gggattctat gaaccatgga tgttcgtcgc ttgtgtggtt 3036241 cacaacgaga tccataatca gcttcatatc cagatcatga atgtcaccaa gcagctcatc 3036301 aaaatcttcc atcgtgccaa actcgcttaa tatgttttga taatccctga tatcatagcc 3036361 attatcggca ttcggtgaat catacagcgg gcaaatccat atgacgtcag cgcccagctc 3036421 ttttatgtaa gaaagcttgg ttctgattcc ttgaatatcc ccgattccgt cgccatttga 3036481 atctttaaaa ctgcgggggt aaatttggta aactacggct tccttccacc aagccttttt 3036541 catacagcca ctccttccca gtgtaccgtt cttatatatc ctatgtagaa aaaggtcttt 3036601 acagcattgc tttttaagaa atgacttgat gacacaaaaa acagccgttt gttccccggc 3036661 tgttttttat caaaaatcag ttttttttat ttctacaaaa cggatgtggt gatcttcggc 3036721 gtcgaggatt ttaaattcac agccctccgc gtgtatcaca tcccctgctt tcagctccat 3036781 tttttgcgtt agaagccagc ctgcaatcgt atcaatttct tcattttcaa tcgcaatgtc 3036841 gagaaggtca ttcacttcgt ctattagcgc ttttccatcc atcacataat ggtgctcgcc 3036901 ctttttcagg atgtgcggtg tttcatcctg atcatactca tcgcggattt ccccgacgat 3036961 ttcctcgata atatcctcta cagtgacaag ccccgccgtt cccccgtatt catcgacaag 3037021 aatcgccatg tgaatccgct ccttctgcat gcggattaaa agctgctgaa caggaatgct 3037081 ttcaatgact ctgataacgg gcctcatgat ttgattcagc tttatcggct ggccgagaaa 3037141 ataagcttta aacatatctt tgctgttgat gatccctaaa atatgatcct tgtcatcttt 3037201 gatgacaggg tagcgtgtat accgttcatt aatgatgtga tgaattgcct cttcaagcga 3037261 ctgctccaga gagataaccg caatttctgt ccgcggaatc ataatctctc tcgctacccg 3037321 gttgtcaaat tcaaaaatct tatttacata gcggaattca gactgattga tttctccctt 3037381 ttcatagctt tcagaaagga tcagccttag ttcctcttcg ctgatgacaa cctgatgctc 3037441 ctttaccgaa tgaaagccaa acaatttcac aagaaaactt gcagagccgt ttaatgcttt 3037501 aataaacggg tacgtgattt tataaaacca gatcagcggc tttgcaatcc ataagcttac 3037561 agcttcagct ttttgaatag aaaccgtttt cggggcaagc tcccccatca ccacatgcaa 3037621 aaaagtgacg atgataaatg caactacaaa tgtgacaatg tggttaaacg gttccggtat 3037681 gcctgtcatt gtaaataagg gatgaagaaa acgttcaaat gtaggttcac caagccaccc 3037741 aaggccgagg gctgtaatcg taatcccgag ctggcaggct gataaatact cgtcaagatt 3037801 ggagatgatt ttatgtgcgg ctagtgctcg gctgtcaccg ctttcgatga gctgattgat 3037861 ttttgaacct ctgattttga cgatcgcaaa ttccgctgca acgaaaacag ccgtaatgcc 3037921 aatcaaaaca aaaatggcga tcaattgtaa aataagcaaa aaaagccctt accataaatg 3037981 gtaaggggcc acctccttaa cgttaattct catcacgacc gtttaagaaa atcatcacaa 3038041 aacgaagtag ttcaaacagg gaaaccaggg cggcggccac atacgttaag gcagcagcac 3038101 tcagcacttt atttacccca ttttcttcat tgtttcggat gaatccttct gacacaataa 3038161 tctgcttcgc acgtgaactt gcattgaatt cgacaggcaa tgtaatcagc tggaaaaaga 3038221 cagccgctga aaacagtatg atgccaagcc cgatcaaatt caggctgccg agaagcatgc 3038281 ctcctaagaa aagcaaagga gctacaccgg atgcaaaatt cacgactggg aagattttat 3038341 gtctcagcac aagcgcacca tatgactcct gatgctgcaa ggcatgtccg acttcatggg 3038401 aagctacgga tatggcggaa attgagcggc cgtaatagac cggctcagat aaacgcacca 3038461 cccgtcttgt cgggtcgtaa tggtctgtta aagtgcctct taccggttcg accggcacgt 3038521 cgtaaagacc gtttatatct aaaatccgtc ttgccgtttc tgcccctgta cgtccgcttg 3038581 aggcttccac ttttgaatat ttttcaaagt tgctctttac tttaaattgt gcccaaaacg 3038641 acaatcccaa tgcggctatt gttaaaaata taaacagcat tttttcatca tcctttgttc 3038701 atgatcattt ctctattacg attattttaa tgagttttct ttctcgtgta cagaaatgcg 3038761 ctttttcttc cggcttggag cacacaatcc aatcagcaaa aagaacaggc ctgctgaaaa 3038821 caaataaaag gcgaaactgc cggccagttc tttcagaaaa tgaagccagg agaagcttcc 3038881 ggaaaagtga ttatatgaat tcaaatcgaa aataaacaaa atcaccgcgg atgccgccag 3038941 ctgcgtaccg attaaaacca cgatcgttct ttgaaagatc gtcatctttt tcatcctttt 3039001 tgttttagtt tatggagaaa tccggtttta tatgttttgt acattttttg aaaaacatca 3039061 ccggaagtgg gacatactgt tagaaaaaag cacgggtgtg atggaagcta tgaaagtgac 3039121 gagtgaggaa aaggaacagc tgagcacagc aatcgaccga atgaatgaag gactggacgc 3039181 gtttatccag ctgtataatg aatcggaaat tgatgaaccg cttattcagc ttgatgatga 3039241 tacagccgag ttaatgaagc aggcccgaga tatgtacggc caggaaaagc taaatgagaa 3039301 attaaataca attattaaac agattttatc catctcagta tctgaagaag gagaaaaaga 3039361 atgaaatcaa atcggatatt tatttcatgg ctcaggtggc cgttatttat ccgaatcggg 3039421 gttattattt tatgtctgat tcttttgttc ggccaaatca tttatatact tgagcctaag 3039481 cagttcactt cggtattcga aggtatttgg tgggctgtcg ttacggtttc tacagtcggt 3039541 tatggagact atgtgccgca cactccgctg ggacaggcag ccggaatact gctgattttg 3039601 agcggagcaa gctttgtcac agcgtatttc gctacgttat cagcggccgc attcagcaga 3039661 cagcatcgct acattgaagg aaaagttgct tacaaaggcc gggaccacat cattctgatc 3039721 gggtggaatg aaaaaacaaa ccggcttttg aaggaccttc agcttgccgc cccttccaaa 3039781 acagtcgtac taatcgatga atccttaaca gaaggcccgc ttattgaaaa cgttcatttc 3039841 atacgcgggc acgctgccga tgatgggaca ctgaaacggg ccaatattac tgaagcggaa 3039901 tcagtgatga ttactgccga tcagtataaa agtgaaactg atgctgatat gctgtcagtg 3039961 ctgactcttt tatctgttaa aggtcttaat ccccttgctt actgcatcgt cgagatttta 3040021 actgaccgtt ttgtcaccaa tgcggaacgg gcaggcgcaa accaaatcat cggaacttca 3040081 gaatttatca gccgggcgat gctgcagcat taccaagtca agttacggcc gtctaaacag 3040141 cagaacggaa tcaagctgac acttgatcag catgtggagc ttcttgctgt tcctgacgaa 3040201 ctaaagggag cggcttacaa aacctgtgtt ctctatttcc ttgatcacaa cacaacaatt 3040261 ataggcatac aaaaaaagga ggggccgatg ctttcccctc ctcttacata caaggtgctc 3040321 gaaacagatc aattccttgc catctagtgt aacagaacat cctccaattc tttcacgaga 3040381 gaggcgccga tatccaaaaa tgccggatca atttccgcgt cccgcctttc cggttcggaa 3040441 aattgattaa acagtgattg gaaaggccct ccctcggcgt gatcgtcaac atccgcctga 3040501 aacacctgtc tcagcataaa tggcgttccg atccggacgg ccgcccctcg ttcatcgaga 3040561 ctgccctgta ccgcattgac gggaattctt aaaaataaat agccgtctct atcatcaatt 3040621 ttataatcaa agtagccatg atcgtattcc cagccgccgt ttatcacata accgagcggc 3040681 ttcatcactt gttccagttc ttgaagcaga aaagactgcc catctatcgc ggaaggtatt 3040741 ggtatcatca gaatgcccct tttttcactt atcctgtccc gccgaacaag acttcattca 3040801 gaggcgccta catggaaatc gttgtttctt tcgcgcggcc aacaggaaag aaagcgcatt 3040861 caattaagaa gtaaacagcc attgccgctg caagccatac agctgaatcc caagacacat 3040921 aaacaaccgt tgcatagagt cctaatttag tgaaaagagt atgggttcgt tttaaatgca 3040981 aaatccgatg taccgcatcg gtaaaaaggg caagcggcaa accaatgaga agaaaggagt 3041041 ggatgaaaaa atgtgacagc gtgccgccaa agcttgaaga aaaccctgta tacacggcat 3041101 caaaggagat aaggaaactt aaaatagctg cagaaaaacc ggcaatgatg agatgtttaa 3041161 ccaattgttt catgaacatc agcacctttc tgattttata aaaagccgac cggcaaatgc 3041221 cagtcagctt tctcacatta atcttccaga cgtttttcaa gctctgcttt tttctcttca 3041281 aagccaggtt tgccgagtaa cgcaaacata ttgactttat acgcttctac accaggctgg 3041341 tcaaacggat tgacgccaag gaggtaaccg ctcatcgcgc aggctttttc gaagaaatat 3041401 acaaggtatc caaaagtata tgcattcagc tcaggaatgt taacgattaa gttcggaaca 3041461 tttccgtctg tatgggcaag cattgtacct tggaatgctt ttttgttaac gaaatcaaca 3041521 gttttaccgg ctaaatagtt caagccgtca agatcgttat ccgcttcctc aattgtcagt 3041581 tcatgtttag gcttctctac gttcaggacc gtttcgaata aatctctgcg gccttcttgt 3041641 acatactggc ctaaagaatg aaggtctgtt gaatagttcg ctgaagaagg ataaatgccc 3041701 ttctcatctt tcccttcgct ttctccgaac agctgcttcc accattccgc aaagtattga 3041761 agcgccggtt cgtagttgat gagcatttca attgttttgc ccttattata aaggacattg 3041821 cgaacaaccg catattggta tgctgggtta tcttccagtt cagatgttgc aaaatctttg 3041881 ctcgcatcca gggcgccttt catcatgtcg tcaatgttga cgccgctgac agcaatcggc 3041941 aagagaccta cagctgttaa aactgaataa cggccgccga catcgtcagg aattacgaat 3042001 gattcaaagc cttcttcgtt agaaagcgtt tttaatgcgc cgcgctcttt atcagttgtt 3042061 gcataaatcc gcgctttcgc ttcttcttta ccgtatttct cttcaagaag cttgcggaaa 3042121 atacggaaag cgattgcagg ttcagttgtc gtacctgatt tagaaatcac attaatagag 3042181 aagtcaacat cttcaagaag atccatgacg tctctcatat aagatgaact gatgttgttc 3042241 ccgataaaaa tgacttgcgg attgccgcgt tttgcttttg gcaaagtgtt ataaaacgcg 3042301 tgattcagcg cttcaatcgc tgcccgcgct ccaagataag aaccgccgat gccgacaaca 3042361 agcaagacat cagagtcaga tttgattttt tccgcgcttt ttttgatgcg cgcgaattct 3042421 tctttatcat aatgttcagg gaggtccacc cagcctagaa aatcgctgcc cgcgcctgtt 3042481 ttctcatgga tattatggtg tgctgttttt acaaagtccc gcaggtatgt aagttcatgt 3042541 tcgttgaaga aagtcaacgc ttttgagtag tcaaagcgta catgcgtcat tgcttgtccc 3042601 tccataacgg tataatgttt tcatctttca ctttatatga acttatctgt gaaatcaagt 3042661 caagaagaaa gggcggaatg actggattcc gccctttggg tttatagaga cgcgcgaagg 3042721 atggcaagca cgtcatcttt gttcagtttt tggaagttgc cgaagccgcc gtgttccatt 3042781 tccttggctg cgatatcagc aatcagctca agcttttctt ctccaatatt gtaatcagca 3042841 agacgagaag gtgcaccgag gcttgtccag aacgcagaca gtttatcgat tccttcaagc 3042901 gcaatttctt tatctgtttt gccttcagta tcaatgtcaa acatgttgag cataaggttt 3042961 ttaaaacggc ctacatttgt atcaagcgtg tatctcatcc aatttgggaa cagtattgcc 3043021 aaaccgcccg cgtgcggaat atcatataca gctgaaacag cgtgttccat tgtatgagaa 3043081 gcccagtcac cgaagtatcc catttggagc gtgccgttta aagcaatagt accagcatac 3043141 aaaatcgttt cacgaagttc gtagttttcc agatcttcaa gaagcttagg agctgtttcg 3043201 atgaccgtct gcaaaacagc aaagcacatt ctatcctgaa gcggcgtgtt ttcaacatta 3043261 tggaagtatt gttcgaatac gtggctcatc atgtcaacca tgccgtatac tgtttgattt 3043321 tctggaacgg tgaacgtatt ttcagggtct aaaatagaga aacgcggatg agtgacattg 3043381 ctgccccata caaatttctc gtttgtttcc cagtttgtaa tcacggaatc agggttcatt 3043441 tcagaccctg ttgcagcaag agttaaaaca gtgccaaacg gcagcgcatc ctccgctgtt 3043501 acttttttgc tgaaaatatc ccaagcgtca ccgtcatatt tgacgccagc tgcgattgcc 3043561 tttgtacagt caatcacact gcctccgccg acagcaagca gaaaatcaat gtcatgctct 3043621 ctgcaaagtc ctatgccttt ttccactgtc gcaagacgcg ggtttggctc tacacctgac 3043681 agctcatgaa caacagcgcc ctcttctttt aaaatgcctg tgacttgatc ataaaggccg 3043741 ttgcgtttaa tgctgccgcc cccgtaaaca agcagtacat tcttgccgta tcgtttgaat 3043801 tcttttctta attgttcaag ctgacctttt ccaaaaatca gctttgtcgg attataataa 3043861 gtgaaatttt ccatagtaaa acctccaaat gatgctggta aaaaacagat tttccattgt 3043921 aacataagtt gacaaaaaag aaaaagggaa gcagccaaac ggctatttcc ccttttttta 3043981 tagtgatgct ttcaaaattg acagcacatc ttctttgttg agtgatttaa attggccgaa 3044041 tgtaccgtta gccattgcct tgtcagcgat tgtgtcaagc tgctcatcat taatatcata 3044101 atcagcaaga cggttcggag cgccaagact tgtccagaat gcggacagct tatcgatacc 3044161 ttcaagggca atttcttcat ccgttttacc tgcttcttca acatcaaaca cgcgaactgc 3044221 aagctgtttc atgcgggcag ggttttcaga caatgtgtgt ctcatccaat tcgggaacag 3044281 aatcgccagt ccgccggcat gcggaatatc ataaacggct gatactgcat gttcaatatt 3044341 atgagtagcc caatcccctc ttgcccccat agaaagcatg ccgtttaatg cgattgttcc 3044401 tgtgtacagg atcgtctcac gcaattcgta attttcgaga tcattgatca gcttaggcgc 3044461 tgtttcaatg actgtacgca aaagtgattc acacatgcgg tcctgatacg gcgtgtttga 3044521 tacatgatgg aagtattgtt cgaatacgtg gctcatcatg tcaaccatcc cgtagatcgt 3044581 gtggttttta ggtacggtga atgtattcac cggatcaaga atcgagaatt tagggaatac 3044641 gagcgggctg ccccagccgt atttttcttt tgtttcccag tttgtaataa cagatcctga 3044701 gttcatttct gaaccagttg cagcgagagt caataccgtt ccgaatggca aagcatcttt 3044761 tggctgatgc tttttcgtaa cgatatccca cgcatcacca tcatacttcg ctcctgcggc 3044821 aatcgctttt gtacagtcga ttacgcttcc gcctccgaca gccagcaaga aatcaatgtt 3044881 ttgttcttta cagatggcaa cacctttatt aacagtcgac acacgaggat tcggttccac 3044941 acctgctaat tcatgcacgg tcgctccggc tttattcagc tgttcaatca cttgatcata 3045001 caggccgctg cgtttaatgc tgccgcctcc gtacacaagc aatacgtttt ttccgtaagg 3045061 tttgagttcc tccggaagtc tttccacttc gccgcgcccg aaaattaatt tggtcggatt 3045121 ccagtatgta aagttttgca tgacatctcc tccttagatt ttttattatg cagaatgtcc 3045181 tcaccacatg taaagcaatc agctctcacc gatcagcata ccagatggtt ttattttgca 3045241 aggtgctggg aaagaagctg atataagcga gggcaggcca gcttccctca tatggagaat 3045301 gcatgtatag attctccaat atgtcacaat ctataactgt tttaataatt catggaggag 3045361 gttgcaaaac atgagtacca ttcaaagaat ttgtcttgta ttaaccatca ttggcgccat 3045421 taactgggga ctgatcggat ttttccaatt tgacttagta gcggctatct tcggcggcca 3045481 agggtcagct ctttcccgaa tcatttacgg acttgtcgga atcgccggct taatcaacct 3045541 cggtctgcta tttaagccaa acgaggaaag atcacgtgaa gaagcagcaa atcctgaaat 3045601 gcgataggat atcaatcacg ctgaaatagg attttgcatg aaatcaaaag caccgaacat 3045661 tcctgtccgg tgcttttttc atgcttattt tttgataagg tctttgcggt tggacatttc 3045721 gatccactct tcaagcttat cttttaatgt gttgaaacct tgtggtgtag aagcttcttc 3045781 gcttacttga gcagctttag gttttcttgg tttgctttct tttttctcag gcgcagcttg 3045841 tgtcgcacga attgaaaggc tgattttgcc tttttcttca tcaacagcaa gtacttttac 3045901 ttgtacttcg tcgccaactg aaaggtgctc gttgatatct tttacgaaac cgtgagtcac 3045961 ttcagaaatg tgtactaaac cttgagtttc ttcatctaat gcaacaaacg caccatacgc 3046021 ttgtaatcct gtaactttac cagtgtaaac actgcccact tcaaattttg ctgccattca 3046081 taacaactcc taagttaaat taaatatctg tttatacgca atttaaaatt atatcacaca 3046141 tgtcttattt ccgcaaagaa aactttttta taaaaaatca ggtttatgca cagcaaaaag 3046201 ggggtaaact gaaaatacca aaggctttct agtattcccc ccttttattg gatgcgaaca 3046261 aaaggttcgt atcttttttt atgttgtttt gtgcaggaag cgtttcattc tgactaacgc 3046321 ttcttgaagc tgttcaatcg aggttgcgta tgaacaacgg atatatccct caccgctcgg 3046381 accaaacaca cttccaggaa caactgccac tttttcctgc gtcagtagct cctcggcaaa 3046441 ctgttctgaa ctcattccca tgcttttgat agatggaaaa gcatagaaag cgccgcccgg 3046501 atgatgacag ctgagaccga tttcattgag cgattctaca aacagattcc gtcttcttcg 3046561 atagcttttt ttcatttttt ctacgtcttc catgccgttc ttcaggcctt caagggcggc 3046621 aaactgcgcc attgcgggcg cgcacatcat cgcatactga tgaattttaa gcatggcatc 3046681 ccgaagcaag gatggtgccg cggcaaaacc gagcctccag cccgtcattg caaatgcttt 3046741 tgaaaagcct gagatgacta ccgtccgttc cttcattccc ggtaatgccg ctatacttgt 3046801 aaattcctca tcatatgtca gctccgcgta gatctcgtcg gctaagacga tgacatcatg 3046861 ttttttggca aactcagcaa tctcattcag ctcttccttc gaataaaccg aacctgtcgg 3046921 attcgatggt gagcagatga gaatggcctt tgttttttca gtgactgccg cttcaaaatc 3046981 agcagccgtt gctttaaatc ctttgtctgc cgttgtatga acgtgaaccg ggataccgcc 3047041 tgccaaagaa acaagcgcat cgtacgcaac aaaacacggc tcaggaatga tgacttcctc 3047101 acctggattc acaatggcgc ggatcgcaat atccaaagcc tgacttgccc ccactgtcac 3047161 aatcagctca ttatctggcg agtagctaag gtcaaacctg ttgctcaaat aacggctgat 3047221 ttcctcccgc aatgagtata aacccgcatt ggccgtgtat gacgtatatc cttgttcaag 3047281 agagagaatg cttgcttcgc ggacattcca tgcggtaaca aaatcaggct cgccgacgcc 3047341 taaagaaatg acgccttcca tcgttgccgc caaatcaaag aatttgcgga tgccggatgg 3047401 ttttatttgt tgtacatagt ctgataaata cgaagtcatt tacggtgaca ccacgattct 3047461 tttgtcgtcg tctcctgttt caaacacttt gccgtcatgc ttgtattttt tcaggataaa 3047521 atgggttgtc gtagatacaa ctgaatcaag cgttgagagt ttatccgaaa caaaacgcgc 3047581 tacgtcagac atcgaattgc cgcgaatcac gacagacaaa tcgtatacgc ctgacatcag 3047641 gtaaactgat tcaacctctt ggaatcggta aatccgttcc gccacttcat caaaaccgac 3047701 gccccgcttc ggcgttactt tgacgtcaat catggccgta acgccctcat gtccgtcgac 3047761 ttttcgccag tcaatcatag cggaataatc gataataacc ttttctttct ccagtttgtc 3047821 aataattgtt ttcacttcat ttacagggat gcccgccatc tttgcgattg tttctaaatc 3047881 ggcgcggctg ttttcgtcta aaatttctaa tatttctgtt tctttttctg tcaatttcat 3047941 ttgattcaca cctttgcaat gtcaagaaat ctcatgacat tatatcacgt tttttgacga 3048001 atgctaagaa aaaacgagga gaaacttccg ctagaattga caatttcagg gcataataca 3048061 accatcaaaa aaagggagtg acacagaatg gaggcggttt caccaataag gcggtttacg 3048121 gtcgatggag tcaatgtata ctacgaacat tatcaaaatc ccggcaggca aacgctggtc 3048181 tgcgtacacg gttttttatc atctgcattc agcttcagaa aagtaattcc tctccttcgg 3048241 gacaagtacg acatcatcgc gcttgatttg cctcctttcg gccaatctga aaaatcaaga 3048301 acgtttatct atacctatca aaaccttgct aagcttgtca ttgggatttt ggagcacttg 3048361 caagtgaaac aggctgtgct tgtcgggcat tctatgggcg ggcagatatc gctgtctgct 3048421 gctctccaaa aacctgagct tttttcaaag gttgtgctgc tttgcagttc agggtattta 3048481 aaacgttcac acccgacgat tattttcggg acccatatcc cgtattttca tctttacatc 3048541 aaacgctggc tctcgaaaga aggcgtgatg aaaaatttat taaatgtggt gcatgacaaa 3048601 tcgctgattg atgaggagat gattgacggc tatggcagac cgtttcagga cgagcagatt 3048661 ttcaaagcca tgacaaggtt tatccgccac agagaaggag atttagaacc cgagcaattg 3048721 aagaaaatga acaagcctgc tctattgatt tggggcgagg aggatcgaat tgtcccaatg 3048781 gagatcggta aacggctgca cgcagatttg cctaattccg tgctgtactc acttggccag 3048841 accggacatc tggtgcctga agaacggcct gaacttattt ctgaacacat tgctgatttt 3048901 atcaaataac aaaaaaaccg gtgctgaacc ggttttttta aggcgtgcag gagctgctgt 3048961 ttttaatgaa taaaagctgg ccagccactt cccggcagct ggcgatcggc agcgtttgtt 3049021 caaaagaagt ttcaaatatt tgctgaatgc ttttcgccag caagtcggga tcgttttcat 3049081 catagactgc ctgcacgaca tcaacagcct ccgtttcgta aaactcttct ccatatttaa 3049141 acgggtccca tttggcaatg atcttaatca tttccctgac cgcatgactt tcttccatat 3049201 tcatcaccgc ttataataaa atttgcagtt ctatcttatc atagtgaagc ttagaagaat 3049261 aaacatacat gagggggtaa cagaatgaac tttgataaac gagaagaacg ccttggcacc 3049321 caatcggtca aatgggataa aacaggcgaa ttatttggcg tgacagacgc cctcccgatg 3049381 tgggtggcag atatggattt tcgcgccccg gaagcgataa ctgaagcgtt aaaagagcgt 3049441 cttgaccacg gtatttttgg ttatacaact ccagatcaaa aaacgaagga tgctgtgtgc 3049501 ggatggatgc aaaacaggca cggctggaag gtaaatccgg aaagcatcac attcagcccc 3049561 ggcgttgtaa cagctttgag catggcggta caagctttta cggagccggg cgatcaagta 3049621 gttgttcagc ctccagttta tacgcctttt taccatatgg tggagaaaaa cggccggcac 3049681 attttacata atccgctgct agaaaaagac ggcgcatatg caatcgattt tgaagatttg 3049741 gagacaaagc ttagtgaccc aagcgttaca ttgtttattt tatgcaatcc tcataaccct 3049801 tctgggcgtt catggagccg ggaagattta ctgaagctag gcgaattgtg ccttgagcat 3049861 ggcgtcacag ttgtatcgga tgaaatccat tccgatttaa tgctgtacgg acataaacac 3049921 acgccgttcg cttcgctctc tgacgatttc gctgatattt ccgtgacatg tgctgctcca 3049981 agcaaaacat ttaatatcgc cggattgcag gcttcagcga tcattattcc ggatcgcctg 3050041 aagcgcgcca agttttccgc aagccttcag cgaaatggtt taggcggact gaacgcgttt 3050101 gccgtcactg caatcgaagc cgcgtattca aaaggcggac cgtggcttga tgaattgatc 3050161 acttacattg agaaaaacat gaacgaagcg gaagcctttt tgagcaccga gctgccaaag 3050221 gtcaaaatga tgaagccgga tgcatcatac ttgatttggc tcgacttcag cgcttacggc 3050281 ttgtccgatg cagagcttca gcaaagaatg ctaaaaaaag gaaaagttat tttagagccc 3050341 gggacgaaat acgggcctgg cggagaagga tttatgcgcc tgaacgccgg atgctctctt 3050401 gcaaccctgc aggacggcct gcgccgcatc aaagccgcat tatcgtaaat atagctgtaa 3050461 acgcctttac gtcttcattt gtaaaggcgt tcttaataaa ggaattttat attttacttc 3050521 taatatttag tgttataata gattcatatt ttatacgaaa ggatttcaca cgaatggaaa 3050581 ttctaaaaga ctatcttctg cacatctgct ttattttgtt tcctattctt ctttaccaag 3050641 tgttttggct tggaaaacct gcgattcttg tgccaaaaat aaacagcggt ttggtcacgc 3050701 tcttcgcctg cggcgcctcc gttttatgca ttattttccc gattcatgaa atggactaca 3050761 tacaatacgg ccttcagatg attcccgtta tcatttgttt attttacatt agtaccgctt 3050821 ccggacttac agtcgccgca tctgtcctat gttttgaact gcttttttac gaaccttccg 3050881 caatgtttgt tttcactttg ctgccttttc ttatcattat cccaatctta tttcagaaaa 3050941 aatggccatt catgtccaaa gcgaaaaaac tgctgctgtc tttattgatc agctgcgtgg 3051001 agattttcct atttttcgcc tcaagctgga ttctttccgc cttgaatatt ttaaattttc 3051061 aaaaatcagg aattttcgtt tacgaggcgg cagtctcagg gcttttccgc tccagtgttc 3051121 ttctattaag catctatatt atcgaaagca tcgccgaaaa tatcgccctg cgttcacagc 3051181 ttatccattc tgaaaaaatg acgattgtga gtgaactggc agcgagcgtc gcccatgagg 3051241 tcaggaatcc gctgacagtt gtccgcgggt ttgtccagct gctttttaat gacgaaaccc 3051301 tacaaaacaa gtcgagtgcg gattacaaaa agcttgtact gtcagagctt gaccgggcgc 3051361 aaggcattat cacaaactat ctcgatatgg ccaaacagca attatacgaa aaagaggttt 3051421 ttgacctatc tgcccttatc aaagagacaa gctcccttat ggtgtcgtac gccaattaca 3051481 agtcagtaac cgtcgaggct gaaacagaac cggacctttt gatatacgga gacgcaacaa 3051541 agctgaagca ggctgtcatc aacctgatga aaaacagtat tgaagcggtt cctcacggga 3051601 aggggatgat ccacatatca gccaaaagaa acggccatac gatcatgatt aacatcacag 3051661 acaatggggt cgggatgaca gaccatcaaa tgcaaaaact cggcgaacct tattattcct 3051721 taaaaacgaa cggaacggga ctcggcctca ccgtaacctt ttccattatt gaacatcatc 3051781 acgggaccat ttcatttaac agcagcttcc aaaaaggcac tacggtgacc attaagcttc 3051841 ccgctgatct tcctcactag caaatcgatt ggaactttaa tagaataaat gcgaggtgat 3051901 gacagatgag cacgtttgag acaggctcta tcgttaaagg attttacaaa acaggtgtat 3051961 acataggaga aatcacggct tgcaggccgc agcattattt agtgaaagtg aaagcggttc 3052021 ttacccatcc cgctcaggga gaccttcatc atccaaaaca ggcggatgtg ccattttttc 3052081 atgagagaaa agcgctcgca tatggtgaac agaccaatat cccccaccat atggtgaagc 3052141 cttatgacgg tgaagtgccg gattataccg aatctctgcg ggaggcgaca gcacagatga 3052201 gagccaaatt gaatgaggat ggttcggagt gggcaaagcg ctcccttcat aatctggaca 3052261 ttttagaaaa agaatatttt aaccggccat aacccagtct gacaaaagat tgggtttttt 3052321 acgtcgcgcg cttcaacagt tcggttaaat cgattctctc gccgattgtg ggcggttttg 3052381 gcttttcgag atactgctta tcctgctcaa caagcttaaa aagtttatat gctgtgagag 3052441 catcatcaag cgctttatga tgggtgccgg ttccggaatc tccatactct tcggcagctt 3052501 tccataaacc cgtcaatgtc cggtctccaa aaaagttttt gtattcaagc gataaatctc 3052561 tcatttctcc cttaaacggg aaagggatat ggttaaacat acagttttgc ttcagcactt 3052621 tcatatccat gtttccccac gtaataattg tgctgttttt ctcaggatcc agctcgttta 3052681 gtttacggat gaaatcctcg aatctcattc cttcgtctac ctgtttttgg gttattttta 3052741 aaaatgattt gcagcgtttc gtaagcttcg ggaacttttt cggtctaaca tagctagaaa 3052801 acgtctcaac cacttcatca tcaatcgact ttacaattcc ggcttcaatg atttccggga 3052861 agaagttttg aggactgtac tttccatcag gcattgtaaa ttcgaaatca ataatgagta 3052921 agctgtttgt cgtcaccttt tacacctgcc tttcctccga tcagaaaatg ctatctttat 3052981 agtatatcaa ttccccttct cgacatttct tcattttcta aaaataatga attttcccag 3053041 ccgcttcgtt tcttttaaat tgtgaatcgt ttctttataa ttagtaagga acccgaaata 3053101 ataagaaggt gatgttattt ctatccgtaa gaaaaacttt gtcattgtgt ggctggcgaa 3053161 cttttttgtc tccgctagca caacgatgat cgttcctttt ctctccttat acattgagac 3053221 gctcagctct ttttcaaacg gctttgtgca aaggtggagc ggctatgtgt tcggcattac 3053281 atttctcatg gcgtttttgg tatccccgtt ttggggacgg ttcggagaca aacgcggata 3053341 caagaaaatc cttatggcaa ccggaacagg cattgccctc agcattttct tcatgggctt 3053401 tgttacatcg gtgtaccaat tgttttttct gcgtatggca atgggtcttg taaccggatt 3053461 catcccgaca tctcttgcga tgatttcggc acagactccg aagagctcag ctggcaaaac 3053521 actcggcacg ctgcaaatgg ggcaagtgtc cggaagcttg ttcggcccgc ttttgggagg 3053581 catgcttgct gatcgtttcg gctttacgta tacctttttt atcacatcct ttgtgatttt 3053641 ctcgtctgtt cttctcgtgt tatttggtgt caaagaaaag catcttgcag agaaaacagc 3053701 caaacgtacg tcttactcga gaaaagaagt gctctcctat atttttcacc atccggcgct 3053761 gtgggtcatg atgctgttaa ccatgctgat tcaaacaggc aatttcagta tccagcccct 3053821 gctcgcttta tatgtaaatg agctgcacgg acctgtcaat cttgcctttt tctccggcat 3053881 ggcattttca gcaacggggc tcggaagttt gctgctggct agaaaatggg gtgatctggg 3053941 cgaccgctac ggccaccgcc gcattttaat cggacttttg ctcgccgcct ctttcttttt 3054001 tattccgcag gcgctcgcgt cctcactcag cgtgctcctt gttttcagat ttttattcgg 3054061 aatggcgatg ggcggtttgc tgccatgcat tacggcagcg atccgcgttc aggctcccgg 3054121 cagcattcaa ggtgaagttc tcggctacaa tgtcagcttt cgctttttag gaaacgtgct 3054181 cgggcctctg ctcggcggaa tcatatcgag ccattttacc atttcggcca ccttttacgt 3054241 cacggcgttt ctctttttcg ccggcgcctg catgctttgg atcatgcaga aacttcggaa 3054301 agattcttat gccaaagcaa gctgattccg agaaaaaact aaggaatctt ctaaatttaa 3054361 ccttctcgta atctcaaaag aatggtacga tatggctaga atttaggaga aaagagagtg 3054421 accatgttac gaaaaataat cggatggatt ttgctccttt gcataatccc attgtttgca 3054481 tttacagtta tcgcttccgg aaaagaagta aaacaaatga agtccctgga tcaggtgctt 3054541 gataaaaata ttgatctgaa agatatcagc cttgttcaga acagctacat gtatgacagg 3054601 gacggctccc ttgtctcgga aatcgtcagc gaccacgaaa accgtgtgct cgttccattt 3054661 aacaagattc ccgaggaagt caaacagatt ttcttaacat ctgaggaccg ccatttttac 3054721 gagcataaag gctttgactt tatgggaatg gtgcgggcta ctgcttctaa cgtaaaagac 3054781 aagaaaattg accagggtgc cagcaccatc acacagcagc tttcaagaaa cttgtatttg 3054841 agccacgaac gctccttcag ccgcaagctg acagagctcg cgtattccta tcagctggag 3054901 aaaaaatata cgaaaaatga aattcttgaa gcttacttaa ataccattta tttcaacaac 3054961 ggtgtttacg gcgtcggttc agcagctcaa ttctatttca gcaaaccgct gaaatctctc 3055021 acagtgggag aaatggcttt tatctgtgct atacctaata accctacatt atatgatcct 3055081 ctcaagcatt ttgactacac gaaaagccgt caagaacgtt tacttaaagg gctaaaagat 3055141 gccggggtca ttacggacaa agagctgaaa aaagccgtaa aacaaaaaat caaactggat 3055201 gttgaaaaaa gagaagacaa atatcctgac tacgtttcct acgtcaatga tgaattcact 3055261 cagctggtgt ctgaatcaga aggctttgat aaacgccttc aaaaagcatc aggaaaacaa 3055321 aaagaaaaga tcgagaacga gctgtccgca agagtcagca cgctgatgaa agacggagtg 3055381 aaaatttata ctgcacttga tccgtacatg caaaatcaag ttgtggcaca aatgaattcc 3055441 aagctcccgt atgcggacgt acagggcgga gcggctgtga ttaatcacca gacgcatcaa 3055501 atcattgctc tatccggcgg gaaaaactat caaaaatatg actttaaccg cgcctaccag 3055561 gcgtacaggc agccgggttc atccattaag ccgcttcttg attacggccc ttatattgaa 3055621 cagaccggcg cgacaacaag cagcaccatt gatgccagca agttttgcag caaagactac 3055681 tgtccgcaaa actacaataa ccgcacttac ggcacagtga cgcttgatac ggcgtttaaa 3055741 aattcatata ataccccggc tattagaatg ctcgaccgcg tcggcatcca aaaggcattc 3055801 agttatattg agccgtatca ttttgccaaa cttgtcgaca gtgactatct tcttccggcg 3055861 gcgcttggcg gatttacaaa cggcatgacg cctcttgaga tgacaaaggc ttatacgaca 3055921 ttcggaaaca gcggaagcta tacgccgagc catgcgatta caaaggtgac agaccttaaa 3055981 ggaaaaacac tttataaatg gaatgataaa gcgactcaaa tattcagcgt ccgcacgaac 3056041 atgcagctga aaaaactgat gtcttccgtt gtgaaaagcg gaacagggaa aaaagcatat 3056101 ttcaatgcgc cttacatcgg cggtaaaacc ggaacatcaa atgattatca cgatatgtgg 3056161 tttgtcggcc tgactgatac gtatacaatg ggtgtctggg tcggaaagga tacaccgacc 3056221 agcgttgaat atcttcacag catcagccct cagctttcca tctggaaagg aacgctgcaa 3056281 gcggcttatt aaaggatcgg aggggatatg gagtgacttc agaacaaatt ccaaatcgcg 3056341 ttttgctgtt tgacggtgtc tgcaatttat gcaatggcgc cgtgcagttt atcattaaac 3056401 gtgatccgga cggattgatt tctttcacat cgctgcagtc ggaaacagga cagagcctgc 3056461 tgaaaaaaag cgggcttccg actgatcggt ttgacagctt tgtctttatt gaagacggcc 3056521 aagtgtacac aaagtcaact gcagccatta aggttttcag gcatctgcga ggcccatggc 3056581 ggctcttcgt cctttttttc gcagtgccga agcctgtcag agatatggtc tattctttca 3056641 ttgccaaaaa ccgctataag tggtttggca aaaaaaatga atgtatgctc ccctcccctt 3056701 ccattaaaaa aagattttta ccgtaaataa aaaatggcta ggaagctagc catcacagat 3056761 tgttgacaaa atcctaaaac ggcttcgttt taggattttg tcatctattc agcgtgattg 3056821 aaaacttttg aagttgtgaa acggcggaaa cctgagaatc tagccgccgt ttcattgcgt 3056881 acagagcacg aagcgcaaat ctgaccacca aacgctgaaa tggctagctt acacaggtaa 3056941 gctagccatt atgctattat aaagcttgat aaatatgaac agaataccga taacaaaggt 3057001 aaaccaaaac agcagttcca atagaatgaa tccaactaat gacatgagag aaagcgtcga 3057061 ataaatccgg tatacggtaa acacaaagta agcgagcgtg acgaccgcaa accagatcac 3057121 aatccaaatg acattttgca agagcacaaa ggataaaatc ccgccgccca aataaatcat 3057181 ggaacccatt ctgagttttt tcaggttgtt cccttccgga tcattagcaa aaaacagcaa 3057241 tgacagctcg gtcacggtat ttgcaattaa tttcagagcg gacagaacca taaaatataa 3057301 aagtgcaaag gcagcaaata acgcaagcct gattcctttc tctgaaaaat aatcgagcat 3057361 tccatcatac attccaaatg aagacagcat cttcaacgca taaagtgaag ttgagatgga 3057421 taaggacgaa ctaaaaagca ggatcgcaat cagcggaaaa tatcctgtca aataagtatt 3057481 tttcatataa aaaagtccct ttctataatc tacctcattt attatggagg acttaaaaca 3057541 cattgacaag ataaattatt ccattttttc tcctttttac gaattacggg cccaaatctt 3057601 cacaaagcag cattttgaga gtaaagtagt acgcaggaat cataaaacgt aaggaagttt 3057661 tatatgaaaa aaacattaaa actgcaaacc agactcacca tatttgtttg tatcgttgta 3057721 ttaatcgcat tgctcattac gttttttaca gtcggtgccc aaaccaccaa acgaattaga 3057781 gatcaggaaa aggccactgc gctgcagact gctgaaatgg tagctgaagc gccgatgaca 3057841 gccgctgctt tagaaagcgg aaaaaaacaa aaggaactgc agagctacac aaagcgggtt 3057901 cagaaaatta ccggcacgga atttgttgtc gtcatggata tgaacggtat ccgcaaaact 3057961 catcctgacc cgagcaaaat cggaaaaaaa ttcagaggcg gtgatgagtc cgaggtatta 3058021 aaagggcatg tccatatcag cacagcctct ggcacgctcg ggaaatcgca gagagcgttc 3058081 gtccctgtct acgcggagaa tggaaaacag gtcggtgcag tcgcggtcgg catcaccgta 3058141 aatgaaattg atgaagtgat cagccatagc ttacggccgc tttactttat tatttgcgtc 3058201 agcatcttcg tcggtgtgat cggagccgtt atcgtcgccc gtacagtgaa aaatatcatg 3058261 tacggacttg aaccttatga aattgcgact ctgcttgaag aacggagcgc gatgctggaa 3058321 tcgacgaagg aaggaatact cgctgtcgat gaacatggca aaattaaact tgccaacgcg 3058381 gaagcaaaac gcctattcgt caaaatgggc atcaacacaa atcccattga tcaggatgta 3058441 gatgacatct tgccgaaaag ccgcttgaaa aaggtcattg agacaaaaaa acctcttcaa 3058501 gacagagacg tccgcattaa cgggctggag cttgtgttta atgaagttcc tatccagctg 3058561 aaaggacaaa ctgtcggagc gattgcaaca ttccgcgaca agaccgaggt aaaacattta 3058621 gctgaacagc tttccggtgt taaaatgtat gcaaacgcac tgagagcgca gtctcatgaa 3058681 tttatgaaca aactgcatgt gatattaggt ctcgtccagc tgaaagagta tgatgatctt 3058741 ggagattata ttaaagatat agccatacag caaaaatcag aaacaagtga aattataaat 3058801 gatgtcaaaa gctccgtact ggccggtttt ctgcttggaa agcaaagctt tatacgtgag 3058861 cagggcgcaa atcttgatat tgaatgcaac ggtgtcatcc cgaacgcggc agacccttct 3058921 gtcatccatg aacttattac aatcatcgga aatctcatca acaatggctt agatgccgtt 3058981 gccgatatgc cgaaaaaaca aatcaccatg tccatgcgct tccataacag catacttgat 3059041 attgaaatta ccgatactgg agcaggcatg tctgaagaag accaagccaa agtatttgaa 3059101 caaggctatt caacaaaggg caaaaaccgg ggattcggcc tttatttcac acagcaaagc 3059161 atcgaaaatt taaaaggcca aatgatcctc acaagcgaaa agaatgaagg aacgacattc 3059221 agtattcgca tcccgtacga accgaaggag gaaaatcatg attaatgtac taatagttga 3059281 agatgacccc atggtgggtg aattaaataa acgatactta agccaaatag atggctttca 3059341 gctgaaaggc atcgcttctt cctttcaaag cgctctgcat attttagggg agcaccatat 3059401 tgacctcatt ttgcttgata tttatatgcc gggaaaaaac gggctggaac tgctgacgga 3059461 attgagagcc caaaatgaag cggttgacgt gattgtcatc tcagcggcca gcgagcttga 3059521 cgtgatcaag aaaacacttc ggtacggagc tgttgattat ttaatcaaac cgtttgaatt 3059581 tgaacgattc caaacggctc tgtctgatta cagacgaaaa caaaaggtgt attcaaccca 3059641 tcgcaacatg agccaaaaag aactggacgc cgagcttttt caaaagaaag aagcaacaga 3059701 aaaagtgcag cttcctaaag gcctgacaaa aagcacgctg aagctgatct ggtccagtat 3059761 ccagtcattt gaaaatgaat cttttacgac agaagacttg gcaaagcaca cagaaatctc 3059821 tcaagtatcc atacgaaaat acttaaagtt tcttgaagat atacaggttc tgaatgtaga 3059881 aatggcgtac ggaacgatcg gaagacctgt gtttcagtac aacgtcaaca acagtaacat 3059941 taacggaata aagcaatatc tataagaaaa cgcactgctt gctttgagca gtgcgttttt 3060001 ctgtcatatc tcttgccaag atgcttgatt ctattgttga taagttatac aagaataaca 3060061 aagggctttc acatttttaa gcaaataatt ctaaaaatag ataattttta aaaaattatg 3060121 cgaaattcta tttatttctt attagttaaa tgataaatta tgattggtta gttgatcccg 3060181 aaaaactaag tcataagtct tacttcagaa aacgatgtca cggttttccg cccggaacgc 3060241 cttccgcatc cttctcttcc ccgcctttcg aaggaaatac tcacaccacg cttattcagg 3060301 gaagaataga actgtctcag cgcattccat ttgttattat cagaaaattt tatcgattct 3060361 aagaaattgt tcaggacagc ccatcacatg actggccgga tcagctttga accaaatttt 3060421 tctggggggt tatatcttga ataaacgaaa aatcggattg gcgatgtcac ttgtgatcgc 3060481 agcaggcacc atattaggag catgcggaaa cagcgaaaaa agcagcggct caggcgaagg 3060541 caaaaacaaa ttcagtgtgg cgatggttac tgacgtaggc ggagtggatg acaaatcctt 3060601 caaccaatca gcctgggaag gcatccaagc ctttgggaaa gagaatgggc tgaaaaaagg 3060661 caaaaacggt tacgactatc ttcaatccaa atctgatgca gactatacaa cgaacttaaa 3060721 taaattggcg cgtgagaatt ttgacttaat ttacggcgtc ggctacttaa tggaggattc 3060781 aatcagcgaa attgctgacc agcgtaaaaa tacaaacttt gcgattatag atgctgttgt 3060841 cgataaagac aacgtcgcaa gtattacgtt taaagagcag gaaggctcat ttctcgtcgg 3060901 agtggccgca gccctatcaa gcaaatcagg aaaaatcggc tttgtaggcg gcatggaatc 3060961 agagttgatc aaaaaattcg aggtcggctt ccgtgccggc gtgcaagcag ttaaccctaa 3061021 agccgttgta gaagtgaaat acgcaggggg tttcgataaa gccgatgtcg gtaaagcaac 3061081 cgccgaaagc atgtataaat caggcgtaga tgttatttat cactctgcgg gcgccactgg 3061141 cacaggcgtc tttactgaag cgaaaaacct gaaaaaagaa gatccaaaac gcgatgtctg 3061201 ggtcatcggt gtcgataaag accaatacgc agaaggccag gtagaaggaa cagatgataa 3061261 cgtcaccctc acttccatgg tgaaaaaagt agatacagtc gttgaagatg taacgaaaaa 3061321 agcgagtgac ggaaagttcc cgggcggcga aacacttacc tacgggcttg atcaagacgg 3061381 agtcggcatt tctccatcta aacaaaatct atcggatgat gtgatcaaag cggtcgataa 3061441 atggaagaaa aaaatcatcg acggattgga aatcccggca actgagaaag agctgaaaac 3061501 cttcaaagct gaataagaat cgcagggata aggaggtcga gcccttatcc cttgtttttc 3061561 ttttattttg aaataaagga gcggtcaatc aatggaatat gtcattgaaa tgctcaatat 3061621 ccgcaaggcg tttccaggta tcgtcgccaa tgacaatatc aatcttcaag tcaaaaaagg 3061681 cgaaatacac gcgttgctcg gtgaaaacgg agcggggaaa tcaacattga tgaatgtcct 3061741 tttcgggctg tatcagccgg agcggggtga aattcgggtg cgcggcgaga aggtgcacat 3061801 caacagcccg aacaaagcga atgaccttgg aattggaatg gtgcaccagc actttatgct 3061861 tgttgacacc tttacagttg ctgaaaatat tattctcggg aaggagccaa agaagtttgg 3061921 cagaattgac cggaagcgtg ctggccaaga ggtgcaggac atttccgatc gatacggcct 3061981 gcagatccat cctgaagcaa aagcagctga catatcagtc ggtatgcagc agcgcgcaga 3062041 aatattaaaa accctctacc gcggtgccga cattctgatt tttgatgaac cgacggctgt 3062101 tttgacgcct catgaaatta aggaactgat gcaaattatg aagaacctgg tcaaagaagg 3062161 gaagtccatc atcttaatca cccataagct gaaagagatt atggagattt gtgaccgcgt 3062221 tacggttatc cgtaaaggaa aaggcatcaa aacccttgat gtccgtgata caaaccaaga 3062281 cgaactcgcc agtctaatgg tcggccgtga ggtatcgttc aaaactgaaa agagagctgc 3062341 tcagccggga gcggaagtgc ttgcgattga cggcataact gtaaaggata cccgcggaat 3062401 agagacagtc agagatttgt ctctttctgt caaagcggga gaaatagtcg gcatagcagg 3062461 cgtcgacgga aacgggcaat ctgagctgat cgaagcggtg acaggactcc gcaaaacaga 3062521 ttcaggaaca atcaccttaa acggaaaaca gatccaaaac ctgacgccaa gaaaaatcac 3062581 tgaatccggg atcgggcata ttcctcagga tcgccataaa cacggtctcg tccttgattt 3062641 tccaatcgga gagaatatcc tgctgcaaag ctattacaaa aagccgtatt cagcattggg 3062701 cgttttacat aaaggcgaaa tgtacaaaaa agcacgcagc ctgatcactg agtacgatgt 3062761 cagaacgccg gatgaatata cacacgctcg ggcattgtca ggcggaaacc agcaaaaagc 3062821 gattatcggg cgggaaatag accgaaatcc tgatttatta attgccgccc agccgactcg 3062881 cggccttgat gtcggagcga ttgaatttgt ccataaaaag ctcattgagc agcgtgatgc 3062941 cgggaaagcc gttcttctcc tctcgtttga gcttgaagaa attatgaatc tcagtgacag 3063001 aatcgccgtt atttttgaag gacgcattat cgccagcgtt aatccgcagg aaaccactga 3063061 acaggagctt ggtctcttga tggcaggaag cacgcaaaag gaagcgggga aagcaaatgg 3063121 ttaaacgact ctctcattta ctcgtgccgc tcatcgcaat catacttggt cttgcggccg 3063181 gcgcgttgat tatgcttgtg agcggctaca gtgtggctag cggatattcg gctttgtgga 3063241 atgggatatt cggagaaatc tattatgtcg gagaaacaat ccggcaaatt acgccttata 3063301 ttttatccgg attggctgtc gcctttgcat tccgaaccgg actctttaat atcggcgtcg 3063361 agggacagct gctcgtcggc tggacagcag cggtttgggt cggtacggcg tttgacggac 3063421 cggcatatat tcacttgccg ctcgcattga ttacagcggc agctgcagga ggattatggg 3063481 ggtttattcc cggcattttg aaagcgcgat tttacgttca tgaagtcatt gtcaccatta 3063541 tgatgaatta tatcgcgctg cacatgacca attacatcat ttcaaacgtc ttgacagatc 3063601 atcaggacaa gacggggaaa attcacgaat ccgcctccct ccgctctcct tttcttgaac 3063661 agatcaccga ttactcacgg ctgcatttgg gaatcatcgt tgcccttctc gcagcagtta 3063721 tcatgtggtt tatcatcaac aaatctacaa aaggatttga gctccgggcg gtcgggttta 3063781 accagcacgc ttcccagtat gccggcatga gcgtgcggaa gaatatcatg acctccatgc 3063841 ttatctccgg cgcttttgca ggtcttgccg gagccatgga gggcctaggg acattcgaat 3063901 acgcagcagt gaaaggcgca tttaccggcg taggctttga cggtatcgct gtcgctcttc 3063961 tcgggggaaa cacagccgta ggcgttgtac tggcagcatg cctgcttggc gggctgaaaa 3064021 tcggcgcatt aaatatgccg attgaatcag gcgttccatc agaggtcgtt gatattgtga 3064081 ttgccattat tattctattt gtggcttcaa gctatgcgat tcgtttcgtc atgggcaaat 3064141 tgaagaaaaa gggggcgaac taagtggaca ttgtgcagat tttatctatc attgtccctg 3064201 ccacactcgt ctatgcggcc ccgcttattt taactgctct cggcggcgtg ttttccgaga 3064261 gatcaggtgt ggtgaatatc ggcctagaag gcctcatgat tatcggggcg ttcaccagcg 3064321 tgttatttaa tttatttttt ggtcaggaat taggtgccgc cgcaccttgg ctttcgctcc 3064381 ttgccgccat ggcagcaggc gccctgtttt cactgattca cgcggcagcg gcgatttcgt 3064441 ttcgcgccga ccagacagtc agcggtgtcg ccattaacat gctggcgctt ggggcaactt 3064501 tatttatcgt caaactgatc tacggcaaag cgcagacaga caaaattcca gagccttttt 3064561 ataagacgaa aatccccggt ttgggcgata ttcccgtctt gggaaagatc ttcttttcgg 3064621 atgtctatta tacgtctatt cttgcaatag cacttgcctt tatttcctgg tttatcttgt 3064681 tcaaaacgcc gttcggcctt cgtatccgtt ctgtcggcga gcatccgatg gcggccgata 3064741 cgatgggaat caacgtatat aaaatgcgct acatcggcgt gatgatcagc ggattgttcg 3064801 gcggtctcgg cggcggcgta tatgcctcca caattgcgct tgatttcacg cactctacca 3064861 tctccgggca aggttttatc gccctggcag cgcttgtatt cggaaaatgg catccgatcg 3064921 gagcactggg ggccgccctg tttttcggat tcgcccaaag cttaagcatc attggatcgc 3064981 tgctccctct ttttaaagac ataccaaatg tgtatatgct gatggctcct tatatcttaa 3065041 cgattctcgc tttaaccggc tttatcgggc gggcagatgc gccaaaagcc aatggcgtgc 3065101 cttatattaa aggaaaaaga taaacattct cccctgggaa gacgattctc agggattttt 3065161 ttctaatcca aaagaccccc ttaatttaat tgtttattag ttttttaact taaaaaaata 3065221 tgaagtgtta acgctttctt gtagactgta acaaacaata catgggggtg tatgacatgg 3065281 gagcaattcc aaaaacgggg acaatttcac ctgagcaaaa agactcacag gagaaaaacc 3065341 tgtttcaaaa aatttggtct tgggaaatcg gtgtgattcc tttgccatta tacacagtat 3065401 tagctgttat tattattctt gcagcatatt acaatgagct gccggcaaat atgcttggcg 3065461 ggtttgccat cattatgatt cttggtgtgt ttctcggaga cataggccaa cgcataccga 3065521 tattgaagga tattggcggc cctgctattt tatctttgtt tgttccttca tttttagtct 3065581 tttacaatgt actgaattca acatctttag acgctgtaac caacttgatg aaaacgtcta 3065641 acttccttta tttctatatc gcttgccttg ttgtgggaag tatcctcggt atgaacagaa 3065701 ttgttttaat acaggggttt atcagaatgt tcgttccact ggttgcagga acgatcgcgg 3065761 ccgttgcagc cggcatcctt gtcggattta tttttggcta tagtgcctat gattcctttt 3065821 tctttgttgt tgtcccgatt attgccgggg gaataggtga agggattttg ccgctttcaa 3065881 tcgcctattc acaaatactg ggctcatccg ccgatgtatt tgtgtctcag ctggtgccag 3065941 ccgcaattat aggaaacgtt tttgctatca tatgtgcagc cttaatgaaa aagcttggcg 3066001 acaagcgtcc agatctaaat gggaacggac gtctcgtaaa atctaaaaaa gcaaatgaga 3066061 ttttcaatca aaaagaagcc gaagcaaaaa ttgattttaa actaatggga gcaggagttc 3066121 tgctcgcgtg tacattcttt atttttggcg ggttattgga gaaattcatc ttcatcccgg 3066181 gcgcgatctt aatgattatt tcagctgcgg ctgtcaagta tgcaaatatt cttccgaaaa 3066241 aaatggaaga aggcgcttac cagctttata agtttatttc ttcaagcttt acatggccgc 3066301 tgatggtcgg tctcggcatc ctctttattc cgttggatga cgtagcgtct gtgatttcta 3066361 taccgtttgt catcatctgt atttcagttg ttatcgcgat gattggttct ggatatttcg 3066421 taggcaagct gatgaacatg tatccggttg aatccgcaat cgttacctgc tgccacagcg 3066481 gtctcggcgg aacgggtgat gttgccattt tatcggcatc aggaagaatg ggccttatgc 3066541 cgtttgccca aatttcaacc cgtctcggcg gtgcaggcac agttatttgc gcgacagtgc 3066601 tgcttcgttt tttcacttca taaacagaaa gagttccgtt ttatgcggaa ctcttttttt 3066661 atttattcac aatccgaata tactctcggg gaccaaacgg cagatccttt gattccgtct 3066721 cactcattct ggctgacagg tggtgctcca gtaaatacag ctcccactca tcacaagccg 3066781 ccacaccgct gcgcccgtca tattgattca acatgaatgc ccctgcaaat actgagcaga 3066841 ataaacctga gcacatcacg acttttgttt tcacatgacc agctcctttc cttcagcttg 3066901 atcaggattg attttaaata tacaaataac ctcttttttg ttagacttat tttgaggtca 3066961 aaagaactca taaaaatcca ttacagcagt tcgaagcgtg gcagcttgca gaaaagtgcg 3067021 atataatttg gactaggtcg tttgaccgta tattttatac atagcgcatt tttcaattga 3067081 gaacgagaaa aggaggtctt atctttgcag ctcttacatc ttgctatttt atcgcctttt 3067141 ttatttgctt ttatcattcc cttcttggca aaatacgcaa aaagagtgca tacgggctgg 3067201 tttgtgttga tcctgcccgt cttgctgttt atatactttc tcccaatgat caggatgacg 3067261 caatctggag aaacacttcg atcggtatta gagtggattc cgtcactcgg cattaacttt 3067321 accgtttata tagacggcct cgggttatta ttcgctttac tgatcacagg cattggctct 3067381 ttggtcactc tttacagcat tttttattta tcgaaagaaa aagaacagct tgggcccttt 3067441 tatgtctact tattgatgtt catgggcgcc atgctcggcg tcgttctagt agacaatgtc 3067501 atggttctct acatgttctg ggagcttaca agcctttcat cctttttgct gatcggctat 3067561 tggtataagc gggaaaagtc gcgctatggc gcagccaaat cacttttgat tacggtcagc 3067621 ggcgggctgt gcatgctcgg cggatttatt ctcctttatt tgataacgga ttccttcagt 3067681 attcgagaga tggttcacca ggttcaatta attgccggcc acgaattgtt tatcccggct 3067741 atgattctca ttttattagg ggcttttacg aaatcggcgc aatttccttt ttacatctgg 3067801 ctccctgacg cgatggaagc tccgacgcct gtcagcgctt atctccattc agctactatg 3067861 gtaaaagccg gcatttatgt gattgcgaga ttcagtccta ttttcgcctt ttcagctcag 3067921 tggttttgga tcgtgtccct cgtcggcctc tttacgatgg tttggggttc attccatgcc 3067981 gtgaaacaaa ctgatttaaa atcgattttg gcgttttcaa ccgtcagcca gctcggcatg 3068041 atcatctcca tgctcggagt cagtgctgcg gcccttcatt acggacatac agaatattat 3068101 acagttgccg ctatggctgc cattttccat ttgatcaacc acgcaacctt taaaggaagc 3068161 ttgtttatgg cagtcgggat tatcgatcac gaaacaggca cacgggatat ccggaagcta 3068221 ggcggcctga tggcgattat gccgattact tttaccattt ccttaatcgg gacattttca 3068281 atggccggcc taccgccgtt taacggattt ttgagtaaag aaatgttttt cacaagcatg 3068341 cttcgcgtga cacattttga cctgttcaac gtgcagacat ggggcgttct gttccctctt 3068401 ttcgcctgga tcggaagtgt atttacgttt atctacagca tgaaattgct gtttaaaaca 3068461 ttcagaggaa attaccagcc tgaacagctt gaaaaacagg ctcacgaagc gcctgtcggt 3068521 atgctcgttc caccggtcat tcttgtcgct ttggctgtca gtctcttctt tttcccgaat 3068581 atattgtcgt acagcctgat agagcctgcg atgaactcaa tctatccgac actgcttgac 3068641 ggccatgaga aattccacgt tcacatttca cagtggcatg gggttacaac ggaattgctc 3068701 atgactgcgg gtattgttgt gatcggaaca attggttatt tgtcgctgaa taagtggaaa 3068761 ggaatctata aactgtttcc ttcgaaactc acactcaacc ggttatacga taagcttttg 3068821 actatgatgg agaaaggctc ttaccgggtc acaaaacaat atatgaccgg gtttttaaga 3068881 gattatttgc tgtatatctt cgctggtttc atcattctga taggcggagc ttttgccatt 3068941 aaaggcggat tttcatttaa aacggaaggc atggctaaaa tcggtgtata cgaaatcatt 3069001 ttgacgcttg tcatgatcag cgccacagtg gcgactgttt ttgctaggtc aagactgacg 3069061 gcgatcattg cactcggtgt tgtcggttat acgcttgcat tgttttttgt cattttcaga 3069121 gcgccggact tggcattgac tcagctcgtc attgaaacga tttctgtggc actgtttctg 3069181 ctttgcttct accatttgcc gaaactgagg ctgaaaacaa aaacgagaac gttccggatg 3069241 acgaatttta tcatttcttt aggcgtcggt gttatcgtta cactgctcgg catcgcatcc 3069301 tcaagccagc ggacaaaaga cagcattgcg tccttctttg tcaaacacag ccacgatctc 3069361 ggcggagggg ataatgtcgt caatgtcatt ctcgttgatt tcaggggatt tgatacaatg 3069421 tttgaaatta cggtattaac gatagccgct ctcggcattt acagcatgat taaaacaaaa 3069481 gtaaaagagg aggggaaaag cggtgaatga acaaaaaaca aatgacttga ttcttcaaac 3069541 cgcgacaaag cttgtatcct ttatcatttt gcttttctct ttctatttat ttttatcagg 3069601 gcataacgcg cccggaggag gctttgtcgg cggactgatc acgtcctctt ccatcgttct 3069661 cttgctcttg gcatatgatt taaaaaccgt gcgttccctt ttgcctgtca atttcattta 3069721 tgtcgcggga gccggccttc tgctcgctgt attaacaggc gttggctcct ttgtcttcgg 3069781 ggctcctttt ttaacccaca cattcggata ctttcagctg ccgatccttg ggaaaacgga 3069841 gctcgccaca gcgacgatat ttgatttagg cgtttatctt gttgtcgtag gcataacgat 3069901 gaccattatt caaacgattg gagaggaaga ataatggaaa tcttaatggc tgtattagcc 3069961 ggtattattt ttatggctgc tacgtatttg ctgctgtcta aaagcctgct tcgcgtcatt 3070021 atcggaacag cactgttaag ccatggcgtt catttaatgc ttttgactat gggaggatta 3070081 aagaaaggcg ccgctccgat tttgagcgag catgccaaat catttgtcga tccgcttccg 3070141 caagccctga ttttgaccgc aattgtcatt tcttttggcg ttacgtcatt catcctcgtc 3070201 atggcctttc gcgcttatca ggaattgaaa tcggacgata tggatcaaat gaggggaaat 3070261 gatcaacatg aataattttg ttattttgcc aatcctgatc ccgcttttgt cggctattct 3070321 tctgattttc atgacgaaga atcttatgct catgagaatc ttcagcacgg cggcatcggc 3070381 catcgggatt gtgattagcg gcatacttgt acagactgtc ttcacaaaag gcatccagac 3070441 actcagccta ggcggatgga aagcgccgta cggcattgtg cttgccgcag accaattcgc 3070501 cagccttctc gttctcacaa cagcgatcat cggtttattg gttgggcttt attccttccg 3070561 ttctgtcggt gaaaaacggg agcgctcctt ttactactcc ggcgttcagt tcttgcttgc 3070621 cggcgtcagc ggagcgtttt taacaggcga tttatttaat atgtacgtat tttttgagct 3070681 tctgcttatt gcttcctata tgctgattgt attaggcggc acaaaaattc agctgcggga 3070741 atcccttaaa tatattgtgt ttaatattgt atcgtctgcc ctgtttgtca taggggtcgg 3070801 ctttttatac gctgtaaccg gtacgttaaa catggcggat cttagcgtga aaatcagcga 3070861 atcaggacaa accgggctga tcactgtgat tggtgtcctg ctgcttttgg tatttggcat 3070921 gaagggcgga atcttccccc tctacttttg gcttccaggc tcttattacg cgccaccggc 3070981 ggcaatctcc gcgttgttcg gcgctttgct gacaaaagtc gggttatatg cgattacgag 3071041 ggttttcaca ttgattttta ttcacgatac agcctttacc catcagttga tgatttggct 3071101 ggcggcgctg actgtgattt ttggtgtgat cggttcactc gcttattcga atgtcatgaa 3071161 aattgtgatc tataacatta ttaccgctgt cggcgtgatt ttgttcggtg tggcagtaca 3071221 cacccccgca tccattcagg gcgcgatcta ctatctgatt cacgatatgc tgattaaggg 3071281 cgctttgttc atgctggcag gtacgctgat cgcattgact ggaaccgcga gcctgcataa 3071341 aatgggcggg ctgatcaaac gctatcctgt tcttggatgg atgtttttca tttccgctat 3071401 ttctcttgca ggcattccgc cactgagcgg atttgtcggc aaatttaaaa ttgcagaggg 3071461 cggcttcgca gaaggtgaat ttacgatatc catgctgatt ctgctttcga gtctgcttgt 3071521 actgtactct gtgctgagga tctttataca tgcgttttgg ggcgaagaaa aagaaacgcc 3071581 aaaaccaaat catcgaacag ctaaaggact tctttatccg gcagctattt ttctcttgct 3071641 gtcccttctc ttcggattgg gtacagaatg ggtgtcgcct tacgttgatc aagcggccga 3071701 gacgctgctg aatccggaaa aatatatcga agctgttctg aaggagtaga tcgcatggca 3071761 tttcaaattt tattaaatgt gtttctcgct ttttgctgga tgttcttaag caacagtcca 3071821 agcgccgcag gattcattac aggctatatt ctgggaatgc tctctctctt tttcttccgg 3071881 cgctttttca ctcgccagtt ttatctatgg aaattgattt ctattatcaa gctctgtttc 3071941 atttttataa aggaactgta ccttgccaat gtcagtgtga tgaaatcagt cttatctcca 3072001 aaactgaata tcagaccggg tatttttgct tttaaaactg aactgacgaa ggactgggaa 3072061 atcaccatgc tttctctgct cattacatta acgccgggaa ccttggtgat ggatatttca 3072121 gatgacagaa caatacttta tattcatgca atggatatcg aggatgcgga aaaagcgatt 3072181 tttgacattc gggagtcatt tgaaaaagcc atacaggagg tgagccggtg atgtttacgc 3072241 tgatcctgca aatcgcgctc ggcattatgg cagtgtctac ctttttgtat gtcattcgtg 3072301 tcattaaagg tccgactgtg cctgaccggg tcgtggctct ggatgcaatc ggcatcaatc 3072361 tgatcgcaat cacggcgctt gtctccattt tgctgaaaac aagtgcgttt ttggatatta 3072421 ttttgttgct ggggatttta tcgtttatcg gaacgatcgc attttccaag ttcctggaga 3072481 aaggagagat tatcgaaaat gatcgaaacc gctaaggtcg ttgtggctgt attcattttg 3072541 ctgggtgctc ttatatgcct cattgcttca tttggcgtac ttcgccttcc cgatgtgttt 3072601 acacgcgctc atgctgcttc taaaggctca acattaggtg tcaatatgat tctgctcggt 3072661 gtcttcttct atttgtggtt tgtgacgggg gagctctccg ctaaaatcct gcttgggatt 3072721 ctctttatct ttattacgtc gcctatcggc gggcacttga tctgccgtgc tgcgtataac 3072781 tccggcgtca agcttgatga gagaagtgtg caagatgact ataacggaat cagaaacttt 3072841 gtgattaaac gaaaagagga ttcttattta taaaaataag cagccggaca ggcagagttc 3072901 cggctgtttt tttatttctt gatgacagcc agcgtgcatc tggatataca gatcagcctc 3072961 tcttgctcgt catatatgtg aatatgatag acaatcgtcg ttctgcctat atgaacgggc 3073021 tcggctatcg cctttaccgt tccttccttt acagatttta aatggttggc gttaatctcc 3073081 aaaccaacac aagcttgcgt tgtatgatca atcaggttct gtgcacctgc gctcgccgcg 3073141 gtttccgcca gggccactga agcgcctcca tgcaaatatc cgaacggctg taccgtccga 3073201 tgatccaccg gcatgaccgc aacgcatcgt tccgctgtgt tttcaacaat ctcaatacca 3073261 agcgcttcaa gcaatgtgtg cttcatatcc atctctacac cccccaacat ttaaagtaca 3073321 ccgtctgatt tcgcaatcaa aaccgcttcc gtccgtgaac cgacattcag cttattgaaa 3073381 atcgatgtca agctgtattc aatggaccgc ttgcttaaat gaagggcatc tgcgatttct 3073441 tggtttgtaa atcccttttc aacttcttga agaatcaggc attctctagg tgtgagcaca 3073501 tcttgttctt tttgagagga aggagccggc tttgtttttt gctgagtcat cagctgttta 3073561 aagtaagcaa aatcgactaa aatttctccg ttgagtacgt ggtatatgta ttgggtgatc 3073621 ttttctttag attccgtttt gctgatggca ccgtgcagac ccgcacgaat cgcttcctcg 3073681 aaataatcct cgacctcata accggtatac acgataattt tacaatgagg attctcttgt 3073741 aaaatctgtt tagaaagctc catcccattg acctcgccgc ctagattcag atccattaaa 3073801 atgagatcat atgacgagaa atcatgctgc ttgataaact gttcgctcgg ttcaggactg 3073861 agacaatcaa cagacaaatt cgaatccgtt tccaaaattg tcttggtgcc ttccatgaca 3073921 gccggatggt catcaatcac tagtatcttt ttcatgtttt cctccctttt actcactctt 3073981 ttccatttta taaaaaagac ttggcctgtg ccaagtcgtt tccgttataa atccattaca 3074041 attcgatttc aatatcagcc ttaaagccct ttccttcact tgtttcaatc cgaaggcgcc 3074101 catctaaagc cctgactctc tccttaatgc cagaaagccc catgctcatg gaatgctcag 3074161 tatttttttc ttgatcaaac ccaacgccat cgtcctcata atgaagaacg attttgtttt 3074221 gaatactgat gagcataatc agcacatccg tcgcctgaga gtgcttgacc gcattagaca 3074281 gaaactcttg aatgatccgg tacaaattca gctgcgaatc cagatcaagg gaagccgtaa 3074341 atctcccggt atttaaacgg atatgaaacg gaacccgctc ctgctgctgc gccaccagct 3074401 tcgacagcgc cttcaccaat ccaagatcat acagaagctg cggccgcagc tcatgacacg 3074461 tctccctcgt catcgaaatc acatcagaca tctgctcatt catctgtaca agcttgtcct 3074521 gcacctcttc acggcacgga ttatcatcct tcttgaaatc acccaaaaac agctcacact 3074581 ggcgttttaa ggaaatcaaa tcctgaagaa ccgaatcgtg gagatcgcgg gcgagtcctg 3074641 aacgctgttt ttcttcgatt gcaaacatta gctttttcag ccagatgggg ttggttccct 3074701 cttgttttaa gtccttcaaa tgttccatga gctcctcaat atgcaggaca ttttccatgg 3074761 acacacttgt ataaaaagac agtgttttca gccacgatat ttcatcacgt gttagccggg 3074821 gagtgttaat attagataaa caaagcagaa cataagaact accgcctcgt tcaccaactt 3074881 tcataagaaa gccttgattg acttctataa ttttcccaat ttctgaagtt acgttttcaa 3074941 attcctcttg ataaaaattc cagtccggtc caacttcatg cttatctaaa aatatcactt 3075001 tgtgatcagg agtaacctca aaggtataag ctttgcttac aagcaaaaca tccagtatag 3075061 tatttttcag ttctttaaaa acttgttgaa gagaagttac acccctcatt agctgagtat 3075121 atttaaaaat actgtcctga tagttgaatt tttcggagaa acgttttaac cgaaatttaa 3075181 aatccatgac ctctttaaaa taaaagacag cgaacatgac aacgaaaaaa aatacagttt 3075241 gacgcacagg gttcatctgg atgtccatta catcaaacag aactaatgca ccaactatta 3075301 gaagagttgg tatcatggca agtagagcat agtatctcat tcttcctaag ataaactcta 3075361 tatcaaacat cttattggct acaaattggt atactaaccc gaacggaatt agtactagta 3075421 atgacgccga agctaatgcc gggaaaatat aattacctgt aaatattatt ggaagaacaa 3075481 aaaatatcaa aaaaggcgca aatgaaagag tgtttgttaa aattagtaat ttaagaataa 3075541 acgaatgctc agcatattta tatttattaa gatgtaagta tatcgctgaa aaagaaaata 3075601 gagtcaaagt tgcaaaagaa accaaattaa gagttgctaa aaaatcaata tctacttgta 3075661 aatagtcttg aaaaaactca ataccaagat taaatattgg tatgatataa agaaaagaaa 3075721 ttctattcaa aaaagtttta cctatttctc caaggtatct ttgtataaat tgaagataaa 3075781 gaataggaga agatataaaa gtaaacaagt taatataccg attgattata tgtcctctaa 3075841 atggtccgcc tgcacttata tatgctatcg aaatgtctaa taacaataga ataagaatat 3075901 aggcagcaaa tgatctcctt tttttattta ctttaagtat ataaaaaata catattatgc 3075961 ttaaaaaata aaaaaacaaa ggaagtacga acagaaaaaa actataaggt ctatttagag 3076021 taactaaatc aaaatctttg agatgaatct tttttccact tctcaaaata tccagactgt 3076081 taatatgact caaatatccc catttcaaat gtttgtctga aggtttttct ttattaattt 3076141 ttaatatgat gtctccctgt ctcagaccaa caaattgtcc atatgaagat tccgatattt 3076201 cttctatcat aaattgactt ttatcatttt tatgaatctt agtcccaata ataattccat 3076261 tcatactgat ataagttgta tagcttatat aaaggatact caaaacaatt acagctattg 3076321 tgaatttttt tattaagttc ttcaatatta atccacctat taatcacccc attgacgggt 3076381 tattggatca gccagataat aatcattata agctttaatt attgtttcag tttcttgcac 3076441 atcaaaacct ataaggcagg cttctttatt tttcaatttt tttaaagcct caggataatt 3076501 taaaaagtag ttaattaggt cttgcatctt gtatccccct ttgtataact taataagcat 3076561 tcctttatta gctctttttt ttctttatct aaatttaatt gttctatagc agaaatacat 3076621 ttctgtttat atatttccaa taataccgaa atgtattgag taactcccgc tttaattaat 3076681 ttttcttgga atttctcttt atcaagtaac gatttataat ataagtcttt atgtgaaatt 3076741 aagtataata aatcttccga agcatcatta aaaaggcgct taagatataa gtaaatcagt 3076801 gtatgtttgt ttttttcaat atcactgcga tttccggata aaagaacata ataatctcca 3076861 gaaatttgag ctataatccc tttatagtag gaatatcttt caactgtttc attatattct 3076921 cctgtagcca ataaaacacc tgctacattt gctagtgcaa tcagacttcc acattttaat 3076981 ctaattactt ctaaactttc atcttctgtt ttagatttat tagtgatatc gtcatgttga 3077041 ccttgcatgg cctcgtttac gtattttaaa acatatttaa aaattagagg attgttattt 3077101 aatgaataaa tactcgttaa tcctactgta tacaaggaaa gtgctgcatt taacgactcc 3077161 gagcgattaa ttttcatcca taatgcatgg tgattatctt catcttcaag atcatccata 3077221 atatctgatg aaagaataag aatttctatt cccgcgccaa gccttgttgc aacatctaaa 3077281 ttctcccctc caaaaacaac ataatgtaag attgtggatt cagcaaagga gaatgtttct 3077341 ttagaatcaa taaatgagta aagaagttgt gacaaatcct cgttaaatat gttttgctcc 3077401 acaatctcct tcattttctc cttgatccgg acagaatcta aacatatctg ctcaataacg 3077461 acttcccccc tcccattcca ttttactaaa tgggacattt aaaggacagc aggtttttcg 3077521 ttttttaaca atcatataat actttatcca tttattgtat cggtagaacg aaaaaaaaga 3077581 cttgtttcca agtctttttc acgaaatttt cattgcataa ttgtatttat cgagttgatc 3077641 aatgcttttg ttaatgtttc gtaatgaatc tgtcgtttct ttaatatcaa gttcgagtcg 3077701 gaataacaat tgttttactt cttcaagttt cttttccatc gtttccacac tccttttttt 3077761 gaaagatcaa tgaattgtgt atggtgaacg agtcctaggt atttgatctg ttactaatag 3077821 tgtgtctgct ttcggctcat ttttcaccga aaagtatgca aaaaagtcct gcgtgacacc 3077881 gcaaatctca ataggtcctt atactcaaag gaatcacaac aagaacggga ctatctttct 3077941 atgcgaaaga gcgtttatat gtgctgaaat tgagaaagat tcttaatctc cttgatttta 3078001 acgggtttcg cattttcact aagcaagact atagtccttc ataccgtatt ttcaaaattg 3078061 aatatgcgat tcttggcgtt tcctgaccga caaacaccga aaaagaccgc aacgctaaag 3078121 ttgtggcctt ttcgctttgt catattcggc aattagggat ctatacatat agaaacatcc 3078181 ttttttgcga ggtgctccca tgagatatcg ttatccctgg ttttacgtgt atccgtatga 3078241 ggtacgccgt ccgcccgctc ctgccaacaa tattgatacc tttatccgtt cagcgaagca 3078301 ggccgcaggg atatttgcgg atgcccagct cgttctcagc cgcattgcgg gctcgcggga 3078361 gctttcgcgc cgcattctga ccgcagccga acagtctgat aaacaaacta taaggcgcct 3078421 gatcaaacaa atgggcgtcc ggcatgaagt ggatacggtc tttaatcccg acggcatcta 3078481 tatcagcctt atcggaacgc aaagccgaat gattcttgct ttgcggtggt cagaggaccg 3078541 caatcatttt gcgtccataa gattatgaca ccattccaga gcctctaaat aacattcata 3078601 cgcttcttct ttgtccagtt gattgcctaa ttctgagcaa gtgtcccagt tgttgctttc 3078661 aattaatttc acaagctcaa gcatttggta gtagtcgttt tgatggccta ataatgcttg 3078721 cccgacttca tcttttaaag gcaattcttg aacaatttcc tctatttctc tatgcaggag 3078781 ggtgtctatg agagaaaaca ttccgatcag catataagaa gcaggctgcg gccgggatgt 3078841 ctttctcgcc agcagttcgc aaagctttgc tcttatcaga gaaatcttaa tgatttcgtg 3078901 cttgctggaa tgccctttcc tgcttaaatc cttaaaggaa agaatatata tccaccgttt 3078961 gatttcatta aatcccagca gcataatggc ctgttgaatg ctttcaattt tctggctcaa 3079021 acggctgtgg gatgagttta aaaattttaa aatttgatag gacagtgata aatcccgctc 3079081 tatgtactct gtcacacgct ttatgttagg ctgctcttta ctcagttcgt taagcagttc 3079141 atagtaagaa tagaaatgag tcgataggtc atgcccgctg atgatgcgcg gctcgctgaa 3079201 aaagtagcct tggaataatt gaaagccgtc ttggaccgcc tgtttatatt cttttcgggt 3079261 ctctactttt tccgctaaaa aaatcaggcc gcggcagccg taggtttgca aaattgttct 3079321 gcgttccatt cgtgttgttt tgagaaaatc aattttcaat atatcaatat agctcatgag 3079381 tttttccagt aagtcctcat cttgcggatt tattgcataa aaatcatcaa gcgccagcat 3079441 ataccccatt tttttcaatt ctttgcatct agaaatgagg gccggcgtga tcggtatatc 3079501 ttcaaggatt tcaatgacaa gctgtttcgg attgaaggag gtgggaagat tcgaaaacat 3079561 caggctttcc gtaaaattaa caaaacagcg tttcccttcc gtcagcttct caattccgat 3079621 gtttaaaaag ctgttgatca ccaaatctgt tgttgcctga tcgccgtctt tagcgctata 3079681 cacgttctct tcgctttctc tatacagcag ttcataagca acaacctgtt cttttctatt 3079741 aaaaataggc tgtcttgcaa caaacaccct cattgattta tcccccttac aatacgcgcg 3079801 gctttcaccc ctaagtatat caaataattt gacgaaaatt gtctaaacat gaaaaataat 3079861 atatacataa agaaaactgg cccttcgcga atgaaaggcc agtttttctt tattcttcct 3079921 caagctcttc ttcaattctg cttttcactt cgtggatccg ctgcatttta ttgctccagc 3079981 agtcctcgct taaatcaacc gggtattcct ccggcttgct gattctctta tattcctccc 3080041 aaagcaggct gaggttatcc tgcacatact gctgtatgtc tgaaatctca gggttttggt 3080101 agcaaagaat acccttctca aaaatcagtt catgaagatc cttcgcataa aaattcgtga 3080161 caaatttgct gatgaatgta tgaaccgggt ggaacattct gagccgcttc tgatcattca 3080221 cctgctcatc ataaagcgca atatagtcgc cttcagaatg atggttggac tgattaataa 3080281 tgcggtagac tttctttctg cccggtgtcg tcactttttc aggattggac gaaattttga 3080341 tcgtgtcgac cattttcccg tcttcttcaa tggcaacgag tttataaact gcgccgagag 3080401 ccggctggtc ataggcagtg atcagcttcg taccgacacc ccagacatca atgcgcgctc 3080461 cctgagcctt taaattcata atggtgtgct catccaaatc gcttgaagca atcaccttcg 3080521 catctgtaaa tcctgcttca tcaagcattt tccgggcttt ttttgacagg tacgccaaat 3080581 cgccgctgtc cagacggatg ccaatgaaat taatgcggtc gccgaattcc ttggcaaccc 3080641 taatcgcgtt cggcatgcct gaacgaagcg tgtcatacgt gtcaactaag aagacgcaat 3080701 ccttatgtgt ttccgcgtat tttttgaaag ctgtatattc atcgcggtaa gcctgcacaa 3080761 gcgcatgcgc atgtgtgccg gaaaccggga tattaaagcg ctttccggct cttacattgc 3080821 ttgtcgcgct aaagccgccg attaaggctg ctctcgctcc ccacatggcc gcatccattt 3080881 cgtgcgcccg tcttgttccg aattcaagcg caacttcatc accgatgacg cctttaatcc 3080941 gggcagcctt tgttgcgatt aatgtttgat agttcacaat gttgagcaaa gctgtttcaa 3081001 tcagctgcgc ttctaccagg ggtgcctcca ccctcataat cggctcattg ttaaaaacga 3081061 gttctccttc tttcatggag taaagtgaac ctgtaaaaga taagccgcgc aaatattcaa 3081121 taaaatcttc atgatacccg agttcatcct gtaaataact caaatcgcta tccgtaaact 3081181 tgaaattttc caagtattca atggcttttt ccaagcccgc aaatacggca tagccatttt 3081241 caaacggaag ccttctgaaa aacagctcaa aaatcgcttt cttttcatga atgccgtctc 3081301 tccagtacgt ttccgccata ttgatctgat aaaggtctgt atgtaatgac aggctgtcat 3081361 ctttaaatcc gtactctaac actgtttttc cccttcctta ctctgccact tgcgctccga 3081421 tgctgtttgc aaaatgggaa agagcccatg cgtgcccctc ctgattaaag ctggcaacag 3081481 cttgtttatg cacaacaatc cgaaaacctt tgttgtatgc gtcaacagct gtatgcaaca 3081541 cacaaatatc tgtgcagaca ccggcaagat gcagttcgcc aatctgccgc tctctgagtt 3081601 tgagctctaa atcagttccc gcaaaagcag aatatctcgt tttttccatg tagtaaacat 3081661 taggttcatg ttcatgtttc tgatatagag gcaaaagctt tccgtacaga tcttttcctt 3081721 ccgtgccttt tatattatgc ggaggaaaaa gacgggtttc agggtgatat tgatcccctt 3081781 catcatgaga atctactgct aatacgacgt aatcaccgtt tgtgatgaat tctttagtta 3081841 aattgacgat cgcctcttca atcattctgc cgggctcccc gcaggtcaat tttccgtcac 3081901 tcgccacaaa atcattcgta taatcaatac aaataagtgc ttttttcata gccggcctcc 3081961 ccgccatcag tatgagaaca ttatatctta tctccagttg taagtgaatt gccatgaaca 3082021 aaaagacaaa cggtccgttt gtctcttacg atttcagtac tgaccgatta taaatgtcgt 3082081 cctgaatata tatcaattca cgattcacag cgatatcagc cgcaatgacg atgcctaagg 3082141 gcgtatgaaa ctggagatca gatacaatct tgaaaggcac tccgtaccgg ctcgccattt 3082201 ggatataaga agagtaagac tgatactgaa gctctccatt aatcaaaagg gtgacgttat 3082261 ggctgttttt cagctcgtgc tctgcctctt tatacggttt gcttctaagc acctgtcctt 3082321 tcgtcagtgc caaaacgact ctttctctta aagagcctaa aaacaaatgg cgctcgtcag 3082381 gctttgtctc caaaggccca tacattcctt gctgcaaata gagatccatt ttatcttcac 3082441 tcaaaagcct gtcctcccgt cttgtttgtc ttcattatca cctgatcagg caggagctaa 3082501 actttcaagc gccgtttaca tttctgttac ccaatgaatg atttttttgg ccagctcacc 3082561 agcaggggtt tcctctgtat gccggcgcaa cgacgcttcc agccgttcag gcagagttgc 3082621 tttatcttct tcataggaaa tgatcgtgct ccactccagc tgcggtaccg ctacaagcgt 3082681 gcgcagttct tttctgtttt catgcagata cacgtccgtg atcattccgg tttgcgtatt 3082741 gatatttgct tttctgattt tcataacatg acctctctat tcaaagacta cccatattat 3082801 acaataaaaa agcaacagcc tcttgtgaaa aggctgttac ccgttaaacg aaactgtttc 3082861 atcagtgata tcggcatctt tgaagagagt tttactcgtt tggttgttaa tcttcacaaa 3082921 atcaccaagc tgaaatgtgc ctgaccccgc ccctgaatga gcgacgcttt tgggcgaaat 3082981 cgcaaatacg tctccaaagc ttgccgcggc attatccgta actgacatga tataaatcgg 3083041 ccccacaatt gcaggcattt ccccacctcc gcattgattt acagcatcat atgcaaggag 3083101 ccgataatgg tgcccgccta ttcagctggc tttgcgtttt cctcgagtcg tgaccgctgg 3083161 cgcagcttga tcaagcggac aatattcagg aagaacgcct tcactaccgc ataaaccggc 3083221 accgctaaaa tcatgccgag aattccgccg aagcttcccg ctccgattaa tagcaaaata 3083281 atcgtaagcg gatgggtatt cagccgcttt ccgatcacaa gaggagacag caggtttccg 3083341 tccagctgct gaacgatgac gaccacaata atcgcaaaca gcgctttggc cggcgagtcc 3083401 ataaaaccga caatgacagc cggcgcggca ccgagaaaag gcccgacata gggaatgata 3083461 ttggtaatcg ccatgacaat cccaagaatc agggcatacg gcagtccggc aattaaatag 3083521 ccgataaaac acgctgttcc gacaaaaaga cagattaaca gctgcccctg gaaatatgcc 3083581 gcaagcgtat cggataaatc tttaaaaatc tttaagcctt ctgtccgata agaagccggt 3083641 agaattttta ctgccaaatg cggaaagcgg tgtccgtctt tcagcatgta aaaaaggata 3083701 aatggaacag taataataac aagcgtgatg tttgtcacga caccaaacac cgcagataaa 3083761 ctggacgtga tattttgcgg caggttttgg agaaaacttg tcaatgactg ttcaattttt 3083821 gatatcgata cataatcctg gttcatcatc caggtaaacc attgagaatg ggacaaatcc 3083881 tttgtcagcg cctgaatctg ttttatataa tcaggaaggt tgttaaacag ccctgtcacc 3083941 tgtgcggtga tgataggtcc gactgacgct gaaataaagg caagcaaacc gataaacagt 3084001 aaatagatca atagaatgga taatgtccgc ggaatttttt tctcaagcag gcggacgacc 3084061 ggattaaata tgaaatacaa aattcccgca attagcatcg ggaaaaacaa tgtcgagata 3084121 aaaacaataa acggctgaaa tacaaatgaa acttttgttg ctacaaaaat aatcagcaaa 3084181 acaaataaaa tctgcaatgt ccaaaaatgg acttttgatt tcaacaagct ttgttcctcc 3084241 tagtttttct ttgtctgtca gataaaagaa cttatacccc atcattgtaa caaaaatgaa 3084301 ctcatatcag aactcttaat ataatgaaag gagtgttggt gatgaaggcc gtgacatacg 3084361 atacagattc agaactggct tatatctatg ttcttcctcc gaaaaagaac aggaatgtac 3084421 ggactgagga gctcagagtc aatgattgtc tcctgctgga tatcagccaa gatggcaaaa 3084481 tcgccggatt cgaatgtttt ggtgaggcag cacacctctg tgccccattt gccgggaaat 3084541 cccggctgta tgtaaaagat tcagacggtt atcattttcg ggtctgccag catgcttcag 3084601 tccgttcctg ctatacggtg taccgtgtca ctttctgttt ttcagatggt gactatcagg 3084661 aatttgccgg ctttgacctt gatggaacaa tgtatcatag tgcgttttta cagcgcttaa 3084721 ctgaaaaata ggacgtcctg ttgtacgcct atttttcatg cgcaagcact gttagacccg 3084781 ctcactgtaa tctggggtga cggaaatcat gtgctggatt ctgatcaaac aaacagaatt 3084841 tcgggctcct tcaattgtga tatggtcagg ttttacatcg atcagtctgc ctctgaccgt 3084901 atctcgtact gtctgtataa cgaaccttga gccgatgagc tttttaatgg tctgatagac 3084961 ataaggatcg actaaagaga ccagttgcgg actaccttgg ttgaccatac ttttatcccc 3085021 tttgtgtgtt ttatctcagc ttatgccgcg cttatggata atgacacagg cttacctgat 3085081 aaaacaaagg ggtgcggaga ttttaggaga atacgtttgg aggcgggtgt aaaggaagta 3085141 tcgatgaagc ggagacagcg aagaaagctg gcgctgttcc gtacttatac aggctttatc 3085201 acggatgcct gggcttggtc gattaattgg tccagctttt ctattttttt tcgtgcggtt 3085261 gaaggatcaa tttggcggta atgatggtgg ccgcccggct cttcatccag ttcgtccgct 3085321 tttttgacaa tctgctgcag tgtgttttta tctaattcgc cttcaggcaa ataggaatct 3085381 gtatgaagca aaatggctag tgcaatctct tttgctgctt tcggttcctc gccaagccga 3085441 atcagaagtt tatgcgcccg ttccgcccct ttaatggcat gaatgtcatt tcttttgtat 3085501 ttctcataat cccactttcc gtctgtatac cattcataat ggccaatgtc atgaagcagt 3085561 gccgcttttg ctgctaaatc aggattaatg tcagccttca cagacagcct gtatgcatga 3085621 taagcgcagg caatcgcatg tgccacgccg gaacgctgaa gatatttttg tgcaattgga 3085681 tgggtgaaaa catccattaa tgtaaccttt ctcatggaaa cccctccttt agatattttt 3085741 agaatcctaa cataatttgc agagaaactc aattcttatg tcacatcatt ttgatcttct 3085801 tatcatcatt gttataccct aaaagcaacg tttcagtcag tatatgcggc tgttcaataa 3085861 aatgcgctgg ctgcagcctt ttgtataaaa aaaagagcag aaaatatctg ctctacaaaa 3085921 actctttaat atcataaatg cggccgtttt ccgtcccttt ttctagtaaa gaaagcagcg 3085981 tgccggcaat aaagtccgga ctgcgaaggc ttcctgtttc atttaatttc cggaatcgtt 3086041 caatgtggtg gaaatccttt ttcgatgaag aacggatgac ggcctgcatc tcagtgtcca 3086101 tcactccagg tgagaacgaa atcatgttca ccggcagctc ttcatcctcc tgttcaaatc 3086161 cgaatgtcct cgtaaacatg tcgagcccgg cttttgaact gcaatacgcg ctccatccct 3086221 tatatggatt tttggcggct cctgaagtaa tgttgacaac cgtctttttg ccgctgtatg 3086281 aagcaaaccg ttttgtaaac agctgactca aaagcacggg cgcagtcagg ttcagctgat 3086341 aatggcgctg aagctcgtca agagacgctt cgccggcacg tttgatcggc gttaccattc 3086401 cggcgttatt aataagggta ataccagaat aacgatctga atcgatggat gagagcaatg 3086461 tttcaaattg ctgttcagct tcttcgagat tgatgaggtc tatttgatgc tgcgttagtt 3086521 ttttgtgaga gacatctgtt ttcgttctgg ataaggcatg gacttcatgc cccttttcta 3086581 aagcctgtaa tgcaatggct tgacccagcc cttttgacgc tccggtgatg atataaagtt 3086641 ccattggaaa cctccttttc cgttattatt gtacggcacc tcttttacac aacacaagca 3086701 cgcggcctac gccttcttgt tttcctgcgc tgtgactttt gggatgagga acacgatgcc 3086761 tgcaattccg agcaggatca gtacgacata gatcatcggc agcagcaatg atgatgtttc 3086821 ttgttcatct tctgtttccg ttgatgatgt ctttgtcatt ggtttttcag caaaagtaat 3086881 tccaagctgt ttcgactggg ccgcaatcgt gttggaatcc tcggcatttg ttgatgtaaa 3086941 caaatctttt atcagctcgg cgtccttgtc cttcggttta tcaaaagtga tatccttttg 3087001 ttcctcaggc agttctgttt tttcttcata gtaggtatct tcatgcaaat aattcgtatc 3087061 gatttcgatg tcttttttct catactggtt tggcgcgaca tctgtatttt cttcagtttg 3087121 ggcagccgct gcagagggta tgaaaaggga aaaggagagc atacaaatca tgatcccctt 3087181 ttccatgctg cgatcacgct tcatacgttt catcgctttc tgctgtgtgt tcagccatca 3087241 accggataat cagcggcaga gccacggcaa tcaccgtaat gatcagcaga actgttattc 3087301 ccattgtaaa caagtgccca gtaccgtact ggatgtcgat atatactttc gaaaccggat 3087361 cttcaaatgt aaagttcggc atgatcaaat caataagcgg tgcgacatag aataggatca 3087421 ttgctgctga agcaacccag ccagggattg atccgaatct gaatgccgtc cggatgaagg 3087481 cagagcttgc gaccagcaat agaatcgtaa acaccgacca cttaatcgtc tgatcgtccg 3087541 gcagtgaata aatattcaag ccgaacaagc tgatcataag tccgacaagg atattcagaa 3087601 ttccgaataa cgctcctttg acgagaagcg gtgcgttttg gtaatacgag ctgaaatagc 3087661 cgattaacag actgctgatc aacacaatga caaggatgac aaccggaggt accgtctgaa 3087721 ttttttcttc cggaacctct ccgctgattt taagcggatt cgctaagtaa tcatatacat 3087781 agccattgtt ttgcccgtct actaatgtat ttccgagtat gccgtatacg tcatttcgca 3087841 cgagtttcgt ggaggcgaca tttttccccc agttgttgtt taaggtgtcg gctttcgctt 3087901 gaacatcatt aacgctttgc tgcatgttgg ttgtgtaatc aatgatgccg gactggcgat 3087961 cagacaatga acccatcatg tctgacattt gcagcacttc ctggccgacc gtatcttgga 3088021 cactcagtgc catggtacca gacagcccat cgttgctgaa cgtcgcagat tcctgtgttg 3088081 cgcccgttac aagctgttct gacgcttttg cggcactttc agagattttc gtcagttcgt 3088141 cgagaacacc tgcttgagag tcacggatat agccgctgta gtcgtccgca aatttggtca 3088201 tgccgtcgat gaagctgtta atatcctcat ctgtttgcat cgtgttgttt ttgagagctt 3088261 cccagctggc tgattcttca ggtgtgagag ccaggactga ttggacgttg ccatcttgct 3088321 cttggatgac ttcaccttta ataatagtca aagagcctag atccagatta tcatttagcg 3088381 tagacttata taaatttaaa gagttgtaat acttcatcaa gttagaaata ttatcagttt 3088441 caattctact tgaaaaaatt gaacttagtt tttctttctg atctatatag cctctactct 3088501 gcaaagtttg tattatttcg tcttccaaat tgtatattaa cctataagca tcattgacat 3088561 tattatcaaa atcaaccaac ttttttgtta agtcaccaat ttgatcattt aattttgaaa 3088621 ctgttttatt taactcttta atttcttgat ttaactcatc aatatgtttc tctagtttgt 3088681 tgttatgttc ctcttgtttt tcttgaagtg cattttctat ttcctctaat tttatcgctg 3088741 cttcgttcag acgttttttt gcacctgaaa tatcagtttc accgtcagct ccgtcaccct 3088801 gtagcccatc actttgattt gagccatcgt tttcatctgc gagttcaatc aaagagaaat 3088861 ctgttttaga ggttcctgta ttctccgtgt ttgtatcttg ttcaggaacg ttttttgaag 3088921 attcttgatg tttttgtccc gtttcaatgt tagtttgaac atcattttgt gatccattat 3088981 cttgagtacc ctcttctgat gagccagtat cttcatttgt tggctgatca tcggatgttg 3089041 gaatatcatt cgacggttct tcagtattag gagaatcatc ggttgatggt tcttcagcat 3089101 cgggtgttgt tggtttttct tgttcaggtt cttttaaccc ttcagagata tctttaattt 3089161 cagttgcaac atttttgagc tcatcccgct gcttctctaa atccaatttt atatcttcaa 3089221 tatcttcctt atctgtgtca tctttattat cagatgtgtc ttctccatct tccttttcgt 3089281 cgctttcctt aggtttaagt aaactaaggc ggttcttccc gatattctct tgcaattgat 3089341 ttaaattttg atatttaata gcttcatatt gacttttata tcgagataga aatgcattaa 3089401 acatgtcatt ctcaattttt ttcataccca tttcttgcaa tggcacttga ttttgcctta 3089461 acttttcagc attgttcaac gcaaggtttg tcagtcctat ttgtgtcttc gcttggccga 3089521 tcccggttgc caatccgctc atgcgttcgc tgaactgatt cgccttttgc tgtgcctgga 3089581 tggcatccag acctgtccgg atttgctgct gtgttgaatc ctgggctgcc aaaagcagct 3089641 ttttctgatt ctcttgatat tctttgtacc tttcaactgt atcaatgaat tctttcagcg 3089701 tgtttttggc ttcctccgcc gtagaagctt tttcttttgt cgtgccttgc gcttcattca 3089761 ttgatttctt cagctcatcg attaagtctt tttgctgttt gatttcacct gctaaatcat 3089821 tagagcttgg tttgtaaaag ttgtacatga cattctggaa ttcagattct ttattgacga 3089881 tcttgtcaaa ttctcctctg atgttgtcca ctttttgcga aacaaaattc cagtataagg 3089941 ccgacatttt tttgttcatt gtcttttggg catcctcaag ctcacgctga actttttctt 3090001 tgttaaccgc attcaggtta tcttgaatgc tgaattcgag cgttgccttt tgaggatggt 3090061 ctttgtcata gctcaaaatg ttttttgaga agtctgaggg aatgtagaca atcgcatcgt 3090121 atttctttga agcgagaccg gtctcggccg cgcttcggtt tacgaccgtc cacgaataat 3090181 caggacgttc acccagaacg gccgctactt ccttgccgaa ctgggcggat ttgtcctctt 3090241 catcagactt tacctcatca ctcaatacgc ctgtgtcttc attcaccacc gcgatttgcc 3090301 gggtagaatt gactgctttt ttcgttgggt cgtctccgat aaatcggaaa aacaacaccg 3090361 gcagcagcaa aatgatgatg acggcggata ttaacttgat caagcttttt cgttgttctg 3090421 tcatctagca ctctcccttt cagcagaaca taaaggaatt tgaacttttt gctccttccc 3090481 gttttccaca acatatccga agcccggctg aatctcaggc tcctgtcttt ggtacgggag 3090541 aggaatgaca ttttgctcag actttttcat cagcagaatc gcgtggcgga tttgcttcat 3090601 ctcagtcgtc aaggagtcat agccttttga gaattcgctg tggtttccgc ccgggataaa 3090661 gctgaaccca agatgagcgt atgatttcat gaagttagcg agacgatctt gtattctcgt 3090721 atcaatcgtc tgctggaatc tcgttatccc gtcaatcatc agcacgactt gtgagaatcg 3090781 cagattttgt gcgtctcctt ggcggacggc ttctacatac atggcttctc ttgttttgaa 3090841 aatgtcttct gctgtttcaa tccactgctc aatatcttct ttcgtttcca aatatgaaac 3090901 atctgattcc ttcgcataat gagataagcc gcggtcaatc gagtcaaaca ggccgatcat 3090961 ttcggtttca tcatcaatca gatgttcaag catgactttt aggacgtttg ttttcccgcg 3091021 ctgagtttgg cctaaaatca ggcagtgctt atgcttgccc aaatcaaaat agactgggct 3091081 gactgtttct tcatgaagcc cgatcggtac agataaaggc ttgcgttcca gcttgaagcg 3091141 gatagacaat tctctcgtcg acaagctctc aggcagcatc ggaatcggtg ccggctgctc 3091201 cattgaagca aatcgccctt gaagtttctg tacgtctgat ttcagctcgt tgaacatgcc 3091261 gatatcatca tcggcgtcaa caggcaggaa catttgcgcg aaataaagct cttccttttg 3091321 aatgatgacg cgtcccggaa tcggctcaag attgaatttc ggacggccgt aaatggaata 3091381 tccttctgat tgatccatga gataatggac aatctttgtt ttcaagttat ttaacaatga 3091441 ctggcggaca gcattcaccc gcgttgctgt cagcataaag tagataccca agctttgtcc 3091501 gtctctggaa agctggacaa attccgattc aagctcatgc atctcatcct tgacaatgtc 3091561 aaagttgtca atggtgataa aaatgaatgg aagctcttct tcgctcagcg cattgtacat 3091621 tttgatgtgg ctgatttctt tttcccggaa caaacgttta cggcggtcaa tttcttcttt 3091681 gatgcgaatc atgaactttt caattttcct tgactggtcc atcaggaagt aatccgcggt 3091741 atgcgggagc ttcgctaatg gcagcagcgt tccgtttccg aaatcaaaga tatagacatg 3091801 aagctcttca ggtgtgtata cgtccgcaaa actcatcagg aacgttgcgg ctgcaatcga 3091861 ttttccgtag cccgaagagc cgaagatgcc gatatttcca tcttccatca tcttataagc 3091921 aattggcgcc tgtctttgca gatcaggttc atcgacatac gcaaagtgga aatggtcttt 3091981 ttcgtttgaa gggaaaagag tgcgcggaat acgttccgca agcggcggca gccaagggct 3092041 tggcagcttc tcgattccca tttcatcttg gatgcgttca atttcgtcaa ctacagcttc 3092101 gatttcggtt tgaacgtctt ttttcgcgtt atcttcggta tcaacctcag aaagcgggat 3092161 cagacccgta tctgtgacga tcgcgatttc atcctcggta ccgtagactt cctctaagta 3092221 aggcgccccg ctccatgcag attggaacag ctcatacact tcattgtttc cgacctgcaa 3092281 atagccgcgg cctgttacgg taatgtttgc ggcatcgctg tttttcaaaa tttctttact 3092341 gtcggtggca tcctggacct tgagcgctac tttaaagcgc gagttactcc agatctggtc 3092401 gtcgatgatg ccgcctggct tctgtgtcgc caaaatcaaa tgaacgccga ggcttcgtcc 3092461 gatacgcgcg gcactgacaa gctccctgat aaaatcaggc tcctcgcttt tcagctcggc 3092521 aaactcatca gaaattaaga acaagtgagg catcgccact tctgctttcc cttgcttgta 3092581 tagctttgta tagtcattga tgtgattgac ttgatactgg tcaaacaggc gctgcctttt 3092641 ttttagctcg cttttaatgg aagcaagcgc acgcatactg aagtttttgc ttccttcaat 3092701 atttgtgatc gtgccgagga ggtggggaat gttacggaac ggctgcgcca ttcctccgcc 3092761 tttatagtca attagtaaga aagccgcttc atgcggatga aaatgcactg caagtgacaa 3092821 gatgtaggtc tggagaaatt cacttttccc tgatcccgtt gtccccgcaa gcaagccgtg 3092881 cggaccgtgt gctttttcgt gaaggttcag atacacaatg tcatctttcc ctttatagcc 3092941 gatcggcact gacagcgact tcgacgattc acttgtcagc catctttgct gaatgccgat 3093001 ttcttttact tccttcgcat gaaaaagctc caggaacgat accgtttccg gaatggaatt 3093061 cgtaatgccg acctggtggt tcagcgtccg cagtgtgcgt gaaaaccgtt cgttatcctc 3093121 acgctgatga tgatcgagac ggaacggaat tcttaccgct tttttctttt gtattaaaat 3093181 gtcgccttca tgctcattaa tgtagcggac aagagttgta atgttttccg acaagctttc 3093241 ctttgtttct gcagcgacaa ttgtcgagat gcccagatgc tcatgctgcc cttctaaata 3093301 ttcgagaatg acatgctcag agatcagctg ctgattcgtg atgacaaata caaaatgcgg 3093361 tttgaactgc agtttttctt tgtcatcttc gagatcacgc tctctgatca attcgtaaag 3093421 tgaagacagg agctgatctc gggtttgctc attataaata aatccttttg cataaatatg 3093481 gggcatttga aattgcggaa gccacttcat ccactcccag tctttatact cttcttcatg 3093541 aaaaataaat acgaaacgca aatcgtgata gctgttaaag aacgacagct gtccgattag 3093601 ctggtgaatc tcatttttca caatttgtga tttaccgaca agccccatcg gaccttctgc 3093661 caaatcgacc gtcaccggcg cattacggat atctttatag acgcgttgca tgtgctgcga 3093721 tttctccatg aggtcatcga tatcacgatt cgccaagtct ccgccactca tattgatttc 3093781 atagcttgac ggaactgttc ccgtcccaag ccgcagctgg agataatcct tgctttcaag 3093841 tgatttttcc cagatccggt cactgatttc acttgttaag tatttcattt gttcaaatga 3093901 aggaaagtga aattcaagaa cctgcttttg cttttcagca agtgcctgaa gctctttccg 3093961 cttattgtct aagtaaagct tatatacacg ctcccgtttt tcctcgcgtt ttttccgctg 3094021 gtttttatca cggaaatatt gcactgtcga ggtaatgaga gtcatcataa acatcgccaa 3094081 agaaacgagt ataaatatgc cgcgcggctg gatgatggca actacgccca tcacgatcag 3094141 catcacaagc ggaggcagga tgacgagcca cagccctctg ttggtttgat cgctctcctg 3094201 agagggaaaa ctgaaagaaa cgcggtcatc cggcagatcg tataccatcc gcggcgttct 3094261 tctgtactgc ggatattttt tctgcatctc tgtactcggt ttgaccgttt ctgttaacgc 3094321 tgtttcaaac tgggcataat gaacaatttc taaaaggtct tgttccgtca ccctcatttg 3094381 cgtgaagttc cagaatattt catcccccgg cttgagcggc gtattggcgt tgattttctc 3094441 tccgttcaag aagatcgttc cgctttcagg gcggaccgac cagctgccgc ctgcacggag 3094501 caaagaaaac gtgctttgtt ctgcaaatgc aaaatcttgc ggattcagat aaatatctgc 3094561 attcgttttt tctgaggaac atacaatttc atcccgattt cccgtaaaat aaacggattt 3094621 ctcaggttca ctgcccgtca atatcaagcg tatatcctgc tgatccgttt ggagagtaaa 3094681 tgatatatcc gtctcaatcg tgccgagaca atcatttccc aggaaaactt cgtattggcc 3094741 gccggattcc tttcttttaa gagaaatcac tccgctatta aatggaatgg tgctgatcgt 3094801 aacagaatcc ttcacatcag gccctatggt caccggatga gacgacggga ggttagacag 3094861 atttaatttt tgaacgttat tttggtaaaa aacccataat agactcaaat ggcgaacccc 3094921 cttacggccg aatggcagca tgcgatgacc tgcgcttcat gtctcacgtt atttgtcatc 3094981 ttttttctca tctttctttt ctgtttcttt tttctcgtct tctttttcct tctgttcttc 3095041 ttttttcgct ttttcctcgg ctgcggcttt ttcttctgcc gctttctctt ctgcttgttt 3095101 ttcttcgtct gtttgtgtct gttcttcgct tgtatcgact aacgatgttt cagaattaga 3095161 ctgtttattt tcttgacgtt ctttttgggc tttttcaagc tcactattta ctgaatcaag 3095221 ttctttttgt atgtcttcat catttgtatc ctcagataaa agctgctgtt tatatttagc 3095281 tagggcaaag taaatataat cattgtattc cagcttacgg ccgatactga tcgcttcttt 3095341 gtattctcct cgaccataat caatccaata taagaaatgc tgagggtctg attgaagggt 3095401 gactaaatta ttttctatat ttttggtttt tgcactcccc aggttttcga cctcaacata 3095461 ggacgtcgcc agctgatact gcaccgattc aggcaggctt tccgcatcgt acttggacag 3095521 tgtgctgatg acttcactgt actgcttgtt taagaacgca cggttgctgt ccactatcgc 3095581 ctggtgcttt ggctgcgcga aaaataaggc gtacatcgaa taaataagtg ccggtacaag 3095641 caaaacaatg agccccaggc cgatatatcg ctggatgttc cacttctttc tcgggatatg 3095701 tatgtatgtt tttgctttgg cttcgagctc atcaatatgg gtttgaatca gctcgagcaa 3095761 atcatcatag gattcagcat ctaatatcgc ctttgcctct gcggagaacg tcagcgtttc 3095821 attgaatttc aggtagtctt caaacgcaaa agcgccgtca actgccaaag ccgctgccgc 3095881 tttcagctcc tgccatactc tttcctcatc acgctcgtaa ggaggaatgc tttcttttac 3095941 tccataatgg agaaaataag gcgtaagccc tttatcgaat acaatgtttt caggagcgac 3096001 aatcaaattc agcctcgaca gattgtgctg ctgtacggct tgaacaagct gataggcaaa 3096061 ctgccattta ctttttttat ccttagcttt catgaagcgg aatgctttat aggaggaggg 3096121 aggttggatt gtgatgatta cttcatcatc cgtcacatcg atttctttat gaaaaaatgg 3096181 atttatatct ttgatcacgt tagcttcaag accgtcgaga agctttattt tttcccgttg 3096241 aaaggtaaat gtatagccgg catctgtttt ctcggcaaca gcttctaatt ggttttctaa 3096301 atatgatttt tgttcacctg acattcaacc agatcctttc ataatatttc aagccggtct 3096361 ccgtttgtaa tgccgcaatc agacagcttg cattctccgg aaaacacctt atccttgttc 3096421 accactctga tccagtgccc ttcgcgcgga ggcatagata cgctttgggc ctgccaagca 3096481 atatcaatta cttttttcac cgggtggtaa tctgacaatc tgagatcaaa gacactgccg 3096541 ttataatgtt tcaaatctat tgtaatatca atatacattt aggatcaccc ttacatagaa 3096601 agagcgccgt cttcttttga atcaggcgct ccttcccttt catactgtta tccgcggatt 3096661 tgatttgcga tgtcttggtc agtagactca agtgtatttg ctgtttgatc aagctgctga 3096721 ttcacatctt gaagcaaatc tgacattttg ataaatgaag gtttgagctg ctcgtattga 3096781 tctgcgaacg cttcgcttga agcaccttcc cacatgcttt tcaaatcaga gatcattcgg 3096841 tttaaacgat caacctgatt taatacttct tggctttcaa cgccgtattg cttcgccatc 3096901 gctcttagct cttcgggtgt gacacgaatt aatcctgcca tattcctcat tacctcctgt 3096961 gccatcagcc taaatatggg ctaattcact tatttttaga acgtcattat tataaaaaca 3097021 gtttttcggc atagtcaaac aaatatgttt taattttaca aaatgagtcc aatggtttac 3097081 cccgaatcac tcaaaaatga catatactgt aaagtaaata ggtttatttt cttaatcttc 3097141 tcttcattct ccgaataatc caaaagaccc aaataactct ccaactccca aaaaaaacct 3097201 ttcagaaaat ttgatgctac agcaccattt ctgaaaggtt cagttttttc tttccttaat 3097261 tagtcttgcc tccgatgact ttcttagaag attaatagga taagctgtcg tattatatga 3097321 gacatacact gtcctgcaaa aaggcgatta caccgccaaa tgtatataga acgtttctct 3097381 catgaaattg tttttttgct tctgttcttt gttgttgatt ttcacaaaca acaacaatca 3097441 taataaaagg aaggggatga gatgtcaaag agaaatcaag cacgaaaagt agggagattt 3097501 atgaccatgc cgaatgatcc gtttaaatat agttttgaca gacttgaaga tgtggctgat 3097561 catatcagcg acgttctgcg gtgcccgatc accatagagg atgttaacca caagctgctt 3097621 gcctacagta cacacagcga ctgcacagac cctgcccgga cgtctaccat tattggcaga 3097681 agggtaccgg agaaggtgat taacaagctg tggaaagacg ggacaattcc tgctctctta 3097741 aaaacggacc agccgatcag agtcaagcaa atcgatgaag tcgggctgag caatcgcgtc 3097801 gctatttcga tttggaaaaa caagcaagta cttggcttca tatgggcgct tgagatccaa 3097861 aaaacattgt ccgatgaaga tctgctgaca ttgcaaatgg cagcaaaagc agtgaaaaac 3097921 aagcttctca aacttcaaat cagaaaaacg aaaaatgaag aacgcagcca agaatttttc 3097981 tggaaaatgc tgaccggaca catccatcag gaggatgata tggcggatgg gttccataag 3098041 cttggaatgg ccgctccttc agagttttcc gttatgatca tccgcataaa tggcgagctg 3098101 actgaaaaaa tcgaacagca gctgcaatat ttacaggaaa cgacccagca ggtttacgtg 3098161 ctgctggcga ccgtagattc caatgaactt attatattaa cctcacccaa aacagatcat 3098221 ccttttcaag atttaaaaca gtttgcttta agtacgcaaa aacagctgaa ggagcggtat 3098281 aaaatagaag acgtttctat cgcttttggc ggaatataca actctatttc ttttgtctcc 3098341 cgctcctatc aggaagcatt gtccgtctta aaaacgaagg aacggttcgc tgaagagacc 3098401 aaacatcttt tcagcttttc tgagttaggc atttatcaat acttagatgt cttaaatgaa 3098461 aaacggaaac aggcgggcca ttataattac tcgctttcca aactggaaca atatgaccgg 3098521 gatcaccagt caaatatggt agagacgcta gagcgcttta ttgaagcgga cagcaacgtg 3098581 aataccgctt ccaagctgtt aaatatacac gttaatacgt tgaattaccg actcaagcgg 3098641 atcagccaga tcgctgaaat tgatttgaaa aatgtgaatc aaaaattcac catctattta 3098701 gatatcaaac ttcggcacat ggatttgtga aatttcacaa atccatgttt ttttattttc 3098761 ttaatcaaac aaagaatttt ccaaaatatc aagctacact aaaaatatca catatacagg 3098821 aggagacaga tatgatcata ggggttccta aagagataaa aaacaatgaa aaccgtgtcg 3098881 cattaacacc cgggggcgtt tctcagctca tttcaaacgg ccaccgggtg ctggttgaaa 3098941 caggcgcggg ccttggaagc ggatttgaaa atgaagccta tgagtcagca ggagcggaaa 3099001 tcattgctga tccgaagcag gtctgggacg ccgaaatggt catgaaagta aaagaaccgc 3099061 tgccggaaga atatgtttat tttcgcaaag gacttgtgct gtttacgtac cttcatttag 3099121 cagctgagcc tgagcttgca caggccttga aggataaagg agtaactgcc atcgcatatg 3099181 aaacggtcag tgaaggccgg acattgcctc ttctgacgcc aatgtcagag gttgcgggca 3099241 gaatggcagc gcaaatcggc gctcaattct tagaaaagcc taaaggcgga aaaggcattc 3099301 tgcttgccgg ggtgcctggc gtttcccgcg gaaaagtaac aattatcgga ggaggcgttg 3099361 tcgggacaaa cgcggcgaaa atggctgtcg gcctcggtgc agatgtgacg atcattgact 3099421 taaacgcaga ccgcttgcgc cagcttgatg acatcttcgg ccatcagatt aaaacgttaa 3099481 tttctaatcc ggtcaatatt gctgatgctg tggcggaagc ggatctcctc atttgcgcgg 3099541 tattaattcc gggtgctaaa gctccgactc ttgtcactga ggaaatggta aaacaaatga 3099601 aacccggttc agttattgtt gatgtagcga tcgaccaagg cggcatcgtc gaaactgtcg 3099661 accatatcac aacacatgat cagccaacat atgaaaaaca cggggttgtg cattatgctg 3099721 tagcgaacat gccaggcgca gtccctcgta catcaacaat cgccctgact aacgttactg 3099781 ttccatacgc gctgcaaatc gcgaacaaag gggcagtaaa agcgctcgca gacaatacgg 3099841 cactgagagc gggtttaaac accgcaaacg gacacgtgac ctatgaagct gtagcaagag 3099901 atctaggcta tgagtatgtt cctgccgaga aagctttaca ggatgaatca tctgtggcgg 3099961 gtgcttaatt cacaataagc ttgcagaaag atttctgcag gcttttttat tttttaaaag 3100021 gaaaaaagag accatttcac gaattatgac tatgaagttg atcataaagg aggattcata 3100081 tggctgttca gcaatatggc gtgttaaaag gcatagtatt agacatgaag cgggaaacag 3100141 atgatgacag tcctcatttc caagtcaaaa tgctcggtga agagaatacg tattacaggt 3100201 gcgccatcaa tgtgatgtcc agttctgagg aatctgaagt attgtatttg gctgacgatc 3100261 agtttgattc gggctcaatt accatccttc cgaacatgcc gtatggatat acaaggatca 3100321 atgaagcaaa ccgtgaagtg gcactggatt atgtgcgggg caatttgttt gacccgcggg 3100381 aaatgaagcc tttgcctcat gaaatcacgg gacctgataa tgatttaaat gattttattg 3100441 aaacctatat gaagaaagca caagatgaga aaacgccggt ttatatattc ggttcaaaat 3100501 tcggccctga acaggctgca gataaaatat tcggctttac cccgactaac ggaatgcaca 3100561 atatccatat gaatcaaggg aatgcaatgg atacccgctg gaaaaaagac aacggctctt 3100621 ggcatgacgg gggtattctg attcagtttg cagatcagtg ggccgctgtg tttttagcgt 3100681 ttttatccca atcttggtgt accgatgaaa acggaaaccc tgtcagagat tgtgatcata 3100741 cccaaacgtc tgcgtaagat agaaaaagag actgcggcaa gcagtctctt tttgataaga 3100801 ttacacattt tcaacagtct ttaggctgtt tggcctcata tcgctccaat gcgattggat 3100861 atagtccaaa caagcttcac gccctttttg ctcatgaacg actgtccagc cgctcggcac 3100921 atctataaaa cccggccata gggaatattg gccttcttca ttgaccagca ccaaatatgt 3100981 gccatccgca ttttcaaaag gatttgccat tctatttctc ctcccttatt tattcaactc 3101041 ttccaatttg acagcgagaa ccttgccgat ttgagccaga ggttcaggct gacataaatc 3101101 tttatgacgg cagtcgatgt cgatttgttc aatctgtccg ttaatataag gcttccacga 3101161 gtcaggttca atcgggtcaa accattcagg aatgattgtt gatctgaaaa acaaaacatt 3101221 tccgcggaag gttttcggct tataggaacc taaaatgccg acagaattta catacgtatt 3101281 cttcaaattt aaaatgaccg tttcatccag gctcgcaagc gcactgccgt cacggcgaag 3101341 aatctcaatc gccgcttcaa aatctagcgg tttttcccct aagctgtctg gatcataccc 3101401 gcctaacgcc agaagggcaa taagcgcttc ctcatcatcc ggtgcctctt ttataggaag 3101461 gaagtggttc ggataggcgt ccagcatcac caacagggat acttcttctc cttgattttg 3101521 cagctgggta gccatcgctt gaacgacatt cccgcccagg gaccagccca gcagatggta 3101581 cgggcctttt ggctggaccg ttcggatttg tttaatgtaa tcggcagcca tgtcatcaag 3101641 tgttttcgga agctcctcgc gctgcccgat tccccgtgcc tgcaagccgt agatcggata 3101701 atctgttcct atattggtca tcaaaccggc ataacaccag ctgagccccc ctgccggatg 3101761 aacacagaat aaaggaggct tgtctccgct tgttcggagc ggcagcagaa cgtcaagagc 3101821 gctttggctt gatcccattt caagtctttc agcgagcccg gctacagtag gtgcttcgaa 3101881 caagttgccg atgctgagtt caacgccgag cgcttcacga atgcggctca tgagctgtac 3101941 agcaagcaag gaatgtccgc ctaaatcaaa gaaacggtca tcaatgccga cacgcggcaa 3102001 gtgaagcacc tccataaaga ggtcacagag aatttcttcc tgcggcgttc tcggtcctcg 3102061 tcctgtcact gccgctgcga aatccggagc gggcagcgct ttacgatcaa gctttccatt 3102121 cggtgtcagc ggcaattctt tcatcgtcac aaaggcagca ggcaccatgt aatccggcag 3102181 tctctcagca gcatatctgc gcagttccgc cgtatcaaat gtttcttccg aagggatgac 3102241 ataagctgct aaccgtttat ctcccggctg atcctcacga acgatcactg ccgcatcttc 3102301 aagctgcgga tgctgaacaa gcgcggcttc aatttctccc aattcaatcc ggaatccccg 3102361 aattttcact tgatggtctg cacggccgac atagtcgaga gaaccgtcag cgcggaggcg 3102421 ggccacatcc ccagtgcggt acatccgggt gcctggagga ccgaacggat cagctatgaa 3102481 gcgttcagat gttaaaccag gccggcctag ataacctcgt gctaaccccg ctcctgatac 3102541 atacagctct ccggcaacac ccggcgggac cggctgcagg cgttcatcca gcacgtatac 3102601 accaagatcg ggaatgccgc agccgatcaa gctgtttgcc cgtaaagctg ccatgcttcg 3102661 gtctaattcg atatagctca catgcaccgt cgtttctgta ataccataca tattgataag 3102721 ctgcggtcta ttttcagggt ggcggttgta ccaatcctct aaacggctga gttcaagcgc 3102781 ttctccgcca aaaatgacat agcgcagact gagtgcctgt ccgagatccg gctgttcccg 3102841 ttccgcctgc ataaactgat agaaagcaga cggtgtctgg ttcagaacag tcaccccctc 3102901 tttgacaagc aggcgcagaa acgcttctgg cgatctgctg acgtggtgag gcacgattac 3102961 aagacgtccg ccatgcagca gaggacccca gatctcccac accgaaaaat caaacgcata 3103021 ggaatggaac atggtccaga tatcacctga gctgaaacgg aaccagtgct cggtcgctgc 3103081 aaataaacgt gttacatttt ggtgaggaat catcacacct tttggaacac ctgttgagcc 3103141 ggatgtataa atgacatatg ccgtattcaa aggggaaagc ggctgagtcc tatccttatt 3103201 ttttggatta cctgcagggt acgtgtttag tttctctgcc agctcgggat catccagcac 3103261 gattttcggc acgttttcaa ctggcggaat gtgatttgca gctttagtgt tcgtcatgat 3103321 aaacgcaggc tgtgcatctt ttagcataaa agcaattcga tcagccggat aatccggatc 3103381 aagagggaga taagctgccc cggcctttag caccgccaat aggccgacag ccatttccaa 3103441 cgatcggggc agtgccaatg ccacaaattg ctccggcccg acaccttcac taatcatcat 3103501 tcgggcaagc cggtttgctc tttcattcag ctctgcatag ctcagttcct gattttcata 3103561 tacaacggca atggcatcag gacgtaaagc agcctgcttc tcaaattgct ctggcaaaca 3103621 tgcgtgcgga atcttttcag atacactttg ccaatcagtc accatgctgc tgtgttcctc 3103681 tggcgcaaga atatccagat ttccgatttg ctcgtcagga tcagactcgg cagcctccaa 3103741 caggcgcatc aatcggtcag caagagcctg agcagtttcc cgtttgaaaa gatcagtgct 3103801 gtattcaagc agtccttcca ttccgtttgg tgtcccgtca gcaaggcgat cttcactaat 3103861 ttccagcgtc aaatcaaact tggcagaacc gacactgttg attcgcaggc tgctctccat 3103921 atcaggaaga tgcagttcag cgtccggtgt gttttggaac gcaagcatga tttggaataa 3103981 aggatgcgtc gcacgcgaac gagccggatt gagcacctct acaagtctct caaacggcag 3104041 atcctgattg tcataggcgg ccagattcac ttcccgtact ctgtctagaa gctcacgaaa 3104101 gcttgggtca ccggacgtat cagttctgag caccaatgta ttaatgaaca gccctacaag 3104161 atcgcccagc gcatcatcat tccgtcccgc gatcggactg ccgatcggaa tgtcggtgcc 3104221 cgccccgagc cttgtcaata aagcggcgag accggattga agcaccataa acaggctcac 3104281 cctatttgcg cgagccagct cctgcaatcg cttgtgaaac tcgggctcaa tacgaaaatg 3104341 aatcgtatct ccatcatgac tcggctcagc cggacgtgaa taatcggttg gcagttcaag 3104401 ctgatcaggc aggtttttca aggtttcttt ccagaaagca agctgtccgg caatcaagct 3104461 atttggatca tcctcgtttc caagcagttc ttgctgccaa agcgcatagt ctgcatactg 3104521 cacagcaaga ggcgcccatt cgggagatcg tccgtggcag cgagccgcat aagctgtccc 3104581 aaggtctctg gtcagcggtg ttaaggacca gccgtccccg acaatatgat ggacgagaag 3104641 aagcagcacg tactcgtcag gaccgatcac aaaaagctcg gcacgaaaag caggttcagc 3104701 tgcaagatca aagctgtagc gtacagcttc ggcaagccga tcagaaagct ccttctcagc 3104761 aatttcagta acatgtaact cgggacaggc tcgatcggca tctaaaatat gctgatagga 3104821 tgtcccctgt gattcaggga agatcgtccg aagactttca tgacggcaga cgaggtcata 3104881 aagtgccgct ttcagcaatc cttgatccaa ctcacctgac aaacggacag caaccggaat 3104941 attataagta ggactcggtc cttccagaca atgcaggaac catagccggc gctgggcaaa 3105001 tgagagcggg atcttttcag gccgctcagc tctctgcaaa gcgggacatg cactctgcgc 3105061 caaatcaaga tgggcagcga gtccggctac tgtcggttcg tcaaagagct tggcgatacc 3105121 aagttcggct cccattacct cgcgaatgcg gctcatcaga cgggctgcaa gaagagaatg 3105181 gcccccaagc tcgaagaaac tgtcatcgat accgacgcgt gccaaaccga gaacctctgc 3105241 aaacaagtca cacaatatct cttcctgagg agtccgcggg gcccgatcac tgacagatgt 3105301 gctgaagtct ggtgccggca gtgctttccg gtcaagcttg ccattaggtg ttaacggcag 3105361 ctcgtccatc tccacaaacg ccgacggtac catataatca ggaagactag cccccatata 3105421 acgacgaagc tctgcagtat caatagcagc atcagcgact acataagccg ccaatcgttt 3105481 gtctcccggc tgatcttccc gtacgacaac cgcggcctgt tcaatgtgcg ggtgattggc 3105541 aagcacggca tcaatttctc caagttcaat tcggaatccg cgaattttga tttgatgatc 3105601 cgcccgcccg atataatcca aagacccatc ggcgcgccag cgggcctggt ctccggtccg 3105661 atacatccga gttcccggcg gtccgtatgg atctgcaacg aagcgctccg ccgttaaatc 3105721 aggacgatgg aaataacctc tggccaagcc ggttcctgca atataaagct ctccgacaac 3105781 gcccggcggc accggctgca atccattatc aagcacatac acctgcgtgt tccaaatcgg 3105841 tttcccaatc ggaggaacgc ccttcagccc ttcttcaaga aaagctgcgg cagaccaaat 3105901 cgttgtttca gtgggaccgt ataagttcgt gactgaacaa tgaaggtctt gaagttcctg 3105961 caaaagaccg ctcggcagcg cctcgcctcc tacaagcact ctaagccccc gaagtttctc 3106021 aggttcactc gttaccaaag cgtgccacag tgtcggtgtc gcctgcataa tgttaatatc 3106081 gaaattttca atcatttgag ctaatgcctg cggctcacgg atcgtttctt tctttgcgat 3106141 cacgatttgc gctccgctaa tcagcggaag atataactcc aatgctgaaa tatcaaaagc 3106201 gacagtcgtc acagccaaca gcctgtcttc ttctcctaga gaaaatgcct cctgcataga 3106261 cagcagaaaa ttgcttaagc ttttctgtgt cacaacgact cccttcggtc ttcctgttga 3106321 tcctgaggta tagatgatat acgcaggatg gtcaagcgaa accgatacat cctgattttc 3106381 cggcgaatag cgttttataa tctcctgtgt aacagcctga tcaagcacaa gctcaggtac 3106441 agccaggtca tcaggcagac tggctgctat ttcctcagtc gttatgatgc atgaaggttt 3106501 cgcatcctcc agcatgtaag aaatgcggtc ggctggaaac tccggatcaa gggggagata 3106561 cgccgcacca gtcttgagca caccaagcat tgaagccacc atctcagggg aacgcggcag 3106621 cgccaaagcg acaaattgct ccggaccaat ccctttttcg atcaacagac gcgcgaggcg 3106681 gtttgcctct tcattgagct ttcgatagtt gacttgaatg tcatcacaca tgagagcgat 3106741 acgttctggc gtaagaactg cctgcttttc gaacatgtcc tgaaggctga ccagcttctc 3106801 ggattttgcc gtctcattcc atttagaaat gactttttct ttctcctctg gcaacagaag 3106861 ctccatttgc ccaatcagca tgtcctctcc ggcagaagcc gtttgcagca gctgcaaaat 3106921 acgctgctga tgaagcttaa tatcagactc actgtatacc tcgggattcg catcaacatc 3106981 aattcgcagc ccgctgccgt ctgttctgtc atatacattg attgatagat catcaacagg 3107041 accggctgaa agattatgcg ttgtgccccg gacgccggca aagtcgagac cgtaatcaaa 3107101 cggcataaga ttgatttgag ggccaaataa tctatgattt tctcctatca atttcagatc 3107161 gcgcctaagc tcttcatggc gatacttatg atgtcgccga atactgcgga tttcccggga 3107221 aatttgctga atcagttcag aaaagctcat cgaagagctt accgtcagcc ggagcgggag 3107281 aaggttcatc accatagccg gtacattcag tgacgcggac cctatccgac ccatcatggg 3107341 caggccgagc acaacatcct cagagccggt catacggtgc acataaacag ctgacaccgc 3107401 aatcatgact tcatgccagc ttcctgagaa atagcgcgcc gcttctttta acgcgtttac 3107461 atcagacgga ggcagatatg ccgtatgacg aagaaaactg ttagatgttc ttggcgcccg 3107521 atcagccaag ctcacaactt caggtgcatc tgcaaaacgg tccagccaga attgacgatc 3107581 cttctcatac tgctctgatc cgcgataatc tgtatcctcc tccaaaatgg cctggagaga 3107641 cccaaaggaa cggcttttag ctgtttgtcc ttttataagg gcagtatatg tacttgccac 3107701 acgctgggct atcagggaaa aaccgaagcc gtcgatcgct atatggtgaa tgcgctgata 3107761 ccaaaagaaa cgatcaggcc cggcaataaa cagagcttca ttgaacaaag gggcataccc 3107821 taaatcaacc ggctttgcta aatcagcttt catccagttt aatgctgttt tttccggatc 3107881 aggctcagag ctgacgtcaa tgacgtgcag ctgtacatcc ggagacgggt ttatcatctg 3107941 ccaaggcccg tccatatttt caccgaagcg gacatgcagc gattccgctt ccttgatcac 3108001 gtgccgcaaa gcttcttcaa aaagagcaat attgactggt ccattgattt ctatatattc 3108061 cgctgtattg tagattggat tgtccggatc aagctgctga gcaaaccata tgccagtttg 3108121 cgccccggtc aaagaatatt gaagatcttt tgtatcaggc atccgtttgt ttaccctcct 3108181 tttataaata atccgcgttt ggcagcactt gctggctgcg agttgtgagc aatttctgcc 3108241 attcttcgat cgttgggcgt tcagccaatt ccacgaaagt cacctctgcc ccttcacggc 3108301 gccattgttc caccaatgtc atgatcctta ccgaatcaag accacgatcg agcaaatcct 3108361 cttgatctgt gatgtcttcc ggtgtttctt gtagaagctc agcaatttgt ttacggatat 3108421 tctcacatgt aaacacgttc tttttgccag tgtttgctga cgttttttga acgtctgccg 3108481 gcgcattctg cagctgatca agaagactgt cagtcatcac ggtaaacgca cagcgtccag 3108541 ccgcatattc cagcgccatt tgatgttttt ctaatgaaaa atcagcaact gcatctccca 3108601 caaaaaaggc tttaatatcc tccataaatg cttcacatgc tgtaacaaga cagccgatat 3108661 gggcgtaaat tcctgtaatg atcagctgat cgcgtccctc tttgcgcatc atttcaagca 3108721 gattcgttct cttaaacgcg ctgtatctcc attttgtcag cacaagatca tcatcctctg 3108781 gtgccagctc ggttataatt ttctcctcat aaggaccgct gtttaatccc gggccccaaa 3108841 agtctgtcag cagcgcacgg tcatccggat tttggcttcc cggctgtgcg gtatagacaa 3108901 caggaatccc aagctgaaca cattgattct tcagctttcg tatattcgct gaaagctctg 3108961 ttaccggaga cgctcccgct gtgaaagcat caacaaaata gttttgcata tcgtgtatta 3109021 acaagacagc ccgattcgga tcaggcaccc atgatacttt gttttgcggc atatcagatg 3109081 ctgtcggcat ttgatacggc tgaatggcag gtatagccat atgaacactt cctctcaaat 3109141 tgttgtttta ttttttaaat cctgcaagaa gcttctcgga aatggcttca cggagcgctt 3109201 ttttgctgac ttttcctact cctgtctgcg ggaaggattc gacaaattca actcgatcag 3109261 ggattttata tgccgccagt ccgcgctctc tcaaaaatgc tttaagctct gcggcttttg 3109321 gggcttcatc ccggggaata atgaacacac aagatctttc gccaagaaat tgatcaggca 3109381 tggagaccat tgccgcatca tggacagccg gatgcgccag cagatgattt tctacctctt 3109441 cagccgcaac cttttctcct ccacggttaa tttgatcctt cgcccggcct tcaacgacaa 3109501 tatagccgtc tcgtgtcagc ctgacgatat cacccgtacg gtaaaaaccg tcctcagtaa 3109561 atgaagcggc gttatgctct tctgccttat agtaacctcg aattgtatac ggcccccgcg 3109621 tcagcagatg gcctgtttca ccaggtttta cgtcgcgatc atgatcatcc caaacacgca 3109681 tttcatcata tggagacatc ggttttcctt gggtgttgac aatgatctcc tcaggatcat 3109741 ccaatctcgt ataattgacg agaccctctg ccattccgaa cacctgctgc agcgtgcagc 3109801 cgaaaacagc ttttaccctg cgcgcggctt cagcactaaa cttggcaccg ccgacctgca 3109861 gcacttgaag gctggataaa tcatcacggc gtgaggatgc cgcatccatc cataccatcg 3109921 caagaggcgg aacaagagcg gttatcgtga ccttttcccg ttcaattaaa ggaaatgcgt 3109981 catctggact tggagaagga gataatacca ctcttcctcc agcgtataat acgccgagaa 3110041 cgccgggtga gctcagcgga taattgtgtg ccatcggcag cgcggccaag tacaccgtgc 3110101 tgtggtcgag ccagcagacc tccacactcc gcttcaggct gtatatgtag tcatcgtggg 3110161 tcctcggaat cagtttcgat agcccggtgc tcccgccaga aagctggagg aacgccacat 3110221 ccgatgattt gacttcaggc agttttacag gttctgcatg caaatcctcc agcggtaaaa 3110281 attcctctgc ctcacctgcg acaatgatgt ttttcaaagt cggcagcttg ctttgaacct 3110341 gtctggcaag cgaacggtag tcaaaaccgg aataagcgtc gggaatgata tatgcagccg 3110401 cttcagcaaa ctcgcaaaaa tatgtaattt cactgcttcg atgagaaggc agtgcgaaga 3110461 ctggaagcgc ccccagacgg aaaagcgcga aaatgacttc aaaaaactct ttgatatttg 3110521 gcaactgcac cacaacacga tccatctgtt gaatgccgag cttttgaaat ccggcagcca 3110581 ggcgatcagc ccttgtgtca agctctcgat agctccaatg ggtgtttccg catgtaatgg 3110641 caatgcgatc accatatttg gctgcccggt cccttaacaa atctccaaac gtctcaccgg 3110701 cccagcagcc gttctttcga taggtctcag ctaactcatc aggccaaggc gtaaatcctt 3110761 tcagcatgtt gtatccctcc agcaattcat tctgttcata tgtgatccac gcccattgcc 3110821 cgcagcattg tccgaaactt tgcggacgtc tcctgaagct cgtcctcagg ctttgaaccg 3110881 gccacaacac cagctccagc atacaggcgg agtgagcgtt cttctgcttc tgcacaacgg 3110941 atggtcacga tccattctcc gtcaccggca tcgtcacacc atccgaccat gccggtaaag 3111001 aaaccgcggt caaatggttc aatgctgaga atcgcttctc ttgcaagatc agtcggtgtt 3111061 ccgcagacgg ctggcgtcgg gtggagcgcc gccgccaatt caagtgcggt tacagacggg 3111121 tcggaaagct ctcccttaat cacgctggac aggtgccaca tcgtttccgt tttgatcagt 3111181 gaaggcttct ccggaacctc cagcgtccgg cagaaaggtc tcagcgctgc cgcaaccgcg 3111241 tcagcgacaa ccgcgtgctc atgaagatcc tttgcggaag aaagcaattc agctgcccgg 3111301 cgctggtctt caacaggatc attactgcgc ggtcttgagc cggctaatgg gttggaaacg 3111361 acctgtgttc ccatccttga aacgagaagc tccggacttg ctccgagcaa tgttctgcgg 3111421 ggagacgttt cctcctgact ggacacgtct gcggcaaacg tgtagccatg cgagttatgc 3111481 tgagccagat ggcgaagcaa ttcatccgtc tgaatcggtt caggcgatgt caaatgcagc 3111541 gatctggaca ggacgatttt gctgagtgtt ccatcggcaa tgcgtgccag cccttgttca 3111601 acaccatttt tataatcctc aggttcagga acaggcttta tgtggtatgt atgcccagcc 3111661 tgctgttcct tttcctcatg atcaaattga agcggtcctg accagcgcac ttcttcaggt 3111721 acaacgagcc gcgctgcttt tacttgatca aaaggaacgg ccccgacaac aagcggccgg 3111781 ctttgccctg attgttttgc ctgacgtaac gcctctgcaa ttcggccaga aagggtttcc 3111841 atttggtttt gcccgtctgc ctccggtaca atttcacata tgcctttcgc taacagtaca 3111901 cgatgaggag acgctaagaa aaaggcgccc ggctgatatt catgaagcaa atgctccgct 3111961 tttgtttctg ttataacgtt ttgatccaac attctcatga acctccttta aattcagtta 3112021 cacgcctaag gtcgcgccgc catctacgca taaattatgc atcgtaatat gccctgcctg 3112081 gccagaaacc aaaaagagca ccgcatccgc aatatccgaa ggcttggcta gttttttgag 3112141 cgggatccct gttttaaatg tctcaagtga tccttttatg acttgctccg ctccattctc 3112201 gtcggcccat aatgaccact gcatgtctgt ttccgttgat ccgggagata caatgttgca 3112261 gcgaatattg tattctgcaa gctcaaggcc aaggcatttc gtaaacatca cagccgcagc 3112321 ctttgaagac gcatatgccg ccatagatgt tcttggtaca ccggcagcat tcgatccgac 3112381 tgttacaatc gaacccgatc ttcggtccat catatatttg ctgactgaac gcgaggcgtt 3112441 aaatacgcca gtcgaattca ctgagaacgt cgcctcccat tcctcatcgc taagcgaatg 3112501 gatcagtccc gggcgaagga cacccgctac attcactaaa atatcaatcg gccccatttc 3112561 acgttcgatg cgcgccgtga tctcgtcaat cgccgcgctg tctctcacat ccgcaggaaa 3112621 agcttctgca tggcggcctt ctgctttgag gctgctcaca accttttcca gcttttcagg 3112681 attataatca actgccgcaa tatgtgcgcc ttgactggca agcgtccgcg caacagcttc 3112741 gcctattcct tgggcagccc ctgttataaa agcaattttt ccctctatac cctttgcatt 3112801 catatcatca attcctttct tcgctctaaa tgccaaacag acatccagcg aaaaagactg 3112861 ctgcgccttg aaaaacgcaa tctattgata atgattatca ttatcaatta taaaaataat 3112921 catatccaaa tgtcatgtga cagtcaaata taatttcagt gacaaatatt tttttaaagg 3112981 caaggctgag tatgtctcag cccattgata gatgcggtcc gtcagggtga agcgcaaaac 3113041 gcagcgccct gctgaccaaa acaggaagaa ctgaaatatg tccttctcct gaaaactcgc 3113101 aaaattctgc ccgtatacct tgttcagata aaacggccag ccgctcataa agctcccttg 3113161 cattatcatt catccggctt ttatgatgct gctctaattc tcctgcggca agcaggatat 3113221 tgataggctg attgtttttc ttggtgagag agacgaaatg gtccgttttc ttgagaataa 3113281 acggtttatt ccaatgaatg gacggacttc ccgcgatata cgtttgaaac gcatcgggct 3113341 ttgttagcag cacctgcagc acgaaaagcc ctccgagcga atggccaaag attgtttgtc 3113401 tttttttatc aatctggtaa tctcgttcta tctccggttt taaatcctct tcaataaatc 3113461 tgaaaaagcc ctccgctccg ccatgctccg gccattctct gccgtcgggc ctttccggca 3113521 gcttcgattg ggctgttggc attgtaaaat cccggtggcg tgctgaggag aacggctccg 3113581 ctgtctcata gccaatgccg acgatcactg cagggatcac cccggttttt tcgggtcggc 3113641 gtccctgtat tcgaacggct tccgtcatcg ttccgaagac agaattggca tccagcagat 3113701 aaatcacagg ataaccagcg ggtggcggcg gcgtactagg tttcgagata aaaatgtgat 3113761 aggtacggtt ttcattgcgt gaagacatca tacgcacttc cgtaccagga atcgtaaatg 3113821 cgtttgatgt cccgccattt gtccggtctg ttgtttgttc tttcatgcag tacgacattc 3113881 ctctccttaa actaaaccgc aatgtatgat aatgattttc actatcaact agacacctca 3113941 aataataggt tttcttccaa agaaagtcaa ctttttcccg aataaaaaag gcaccttgat 3114001 caaataaggt acctgcagac tatcaatatg gaagtaaaaa cctaataaag atgcgtattg 3114061 tcctatttga aatagaacct taatcccatg taaacctttg attttgccaa gggtcgcctc 3114121 tcatgtgata gccattccgc tcccaaaagc cagggtgatt ttctttcgta aattggatgc 3114181 cgcgcagcca cttggcgctt ttccaaaaat acagatgcgg aaatacaccc cgcagcggaa 3114241 agccgtgttc aggggttaaa ggttcgccat tatgcgcata agccagaagg gaagtttccg 3114301 ctaagaaatc atcaagcggc agattggtcg tccagccctc ttcagcatgt aaaatgacgt 3114361 agcccgcttc ttcttttaca cccgcttttt ccgctatatc acaagcccgc acgccttgcc 3114421 acacattatc aagccttgac catcccgtga cgcaatgaat gtcgtttttc gattcatacc 3114481 gtggaaaggc tttgacatct tcaaagctta gcagcatcgg atggtcaacc aaaccgtata 3114541 cttgaagatt ccatttcgtc atatcttcgt aatatgggac atctccggta tgaagcacag 3114601 gaaatgaagt ggtgacgttt tgatttggcg gcactcttcc agattgatcg gactgtcttg 3114661 tttttccgaa atacatatgg gcctcctttt tgttaaccta atttaaaatc atgttgacaa 3114721 tctttttgtt ctttattact ctatgattgt gtatgtcaac ctaaggggga acaacgatga 3114781 aacaacgtaa acttcgtgcg ggagatatgg cgctgattgg catgttcgcc gcacttatgg 3114841 ctgtcggggc caacattaca tcagtagcac cctttttaca agtagccggc attccgcttt 3114901 cgatgcagcc gtttttctgt ctcttggcag ctttgcttct tggcagcaaa cgggcagcga 3114961 ttgccatgat tgtatatgca cttgtgggat tggccggagc gcctgtgttt gctcaatttt 3115021 cagcaggctt cgcaccgttt gcagggaaaa gcggcgggtt tattatctca tacattccgg 3115081 cagcatttgc agcgggatgg tttttagaac gaaacattca gccaagtaaa attcgatttc 3115141 tcattgcttc acttatcgga acggcgatca tgtatctcat cggcactacc tatatgtatc 3115201 ttgcactgaa gctgtggatt catacgccag tgagctacgg cacggcttgg ggctttatga 3115261 tttggtttat ggtaaaagat acagcgctgg ctgtgatact gtcgtttatc gcaccagcaa 3115321 tctaccgctc tattcataaa gcaaccggct ttaacagaaa tcacatatca tctacgtaaa 3115381 aaccgttcta ttggacggtt tttttatcat aacgagaaaa ggctccccag taaaggggag 3115441 cctttttcct ataaaacaag cgctgcaatc cagccaaaga tgacaagcgg aatattataa 3115501 aatataaatg tcggcacaca agtatcccaa atgtggtgat gctggccgtc cgcactcaaa 3115561 cctgaagtcg gcccaagcgt actgtcactg gcaggtgaac cggcatcgcc aagcgcagca 3115621 gcagccccga taatcgcaat cgttgccatc gggctgaatc caagctgcat gcatagaggc 3115681 acgaaaatgg ttgtgataac aggaatggtc gcaaaagaag atccgatccc cattgtaatt 3115741 aataagccga caatgagcat cagcaatgcg cccaaggact gactgtgtcc gataaaacca 3115801 gctgacgttt tgaccagtga ctcgacatct ccggttttcg tcaatacgtt tgaaaatccg 3115861 gctgcaacaa gcatgacaaa gccgataaag gccattaaaa ccattccatc agtaatcagt 3115921 gagtccgctt catcacgctt catcacaccg ctgacaaaca gaacaatcag accagcgagc 3115981 gcccccataa tcattccttc tactcccaaa gtctgagata agtaaagctg gacgccgagt 3116041 gacacaacaa tggctagaac cgcgatacca atactttttc tcgtatatgg cgatgcttct 3116101 gcacctgaaa tgtcttttgt ttcatattgt ttcggtttac ggtatacgat cactgataaa 3116161 ataaggccga caaccatacc tgcaactgga ataatcagtg cgtacggaat atcagcaagc 3116221 ggaacgttta acccggcatc cgccatattg tccttcagca tgccttggaa gatttggccg 3116281 aaaccgaccg gaagcaaaat ataaggagcc gttaagccaa atgtaattac acacgcgatc 3116341 agacggcggt ccatttcaag ttcattaaag attttcaaaa gcggcggaat cagcaccggg 3116401 ataaacgcga tgtgaaccgg aacgacgttt tgcgaaaaac aagatacaat taaaataatc 3116461 agcacaatca gcaccttaga cagtgctttt tttcgagaat cttctttatt tccgattaat 3116521 ttaacggagg cttccaccat tgcgtccgga agacccgttt tcgtcaaagc ggcggcaaac 3116581 gcgccaagca tggcatagct aactgcaacg gtggcatttc cgccgagacc gtctgtgaaa 3116641 gctttaaccg tttcgccaag accgagcccg cctgttaacc cgccggccaa ggcgcctata 3116701 attaatgcga taacaatatt gacacgcagc aggcttaata caagcataag caggactgcg 3116761 atgacgactg cattcatgat gatacccctc caaaaatcct ttagtttgct aatgtagtag 3116821 ataaataaag tacgaacgta tcgtatcata accgatccac tttagtcaac taaagatttc 3116881 ggaagaaaaa atccctgccg catcatacag cagggatttt tcattactcg tttttatctt 3116941 cttccaatgt aaatcgctcc gcaagtgtag ccagtgttct tgccataacg ccagtagccc 3117001 cggccggtcc gaagcaggtt gctttattgg cagtcgctgt gcctgcaata tcaaggtgaa 3117061 cccaaggtgt tgactcagcg aattcaccaa gaaacgttcc tgccataatc gcatgtccct 3117121 cgcgtcccgg tgaattgctg agatccgcca tttggctgct tttcacgcgt tttttatcct 3117181 tctctgttat cggcagctgc cagatcgcct cgccgcactc ttgtgcagca tcagctacct 3117241 gctggtaaaa gctttgatca tttgtcattg caccggttgt ttctgttcct aatgccacaa 3117301 cgacgccgcc ggtaagcgta gctacatcga caagaactga tgcgccatgc tgtttcgcgt 3117361 atgtaatgcc atctgcaagc actagccttc cttcagcatc cgtattaagg atttctattg 3117421 tttttccgct taaagatacg atcacgtcat ccggcttcat ggccccgccg gagatcatat 3117481 tatcggttga tggaataacg cacagcacgt tttgttcagg acgaagctct ccgatcgttt 3117541 ccatagcccc gagaaccgca gctgctcctc ccatatctga tttcatgcca acaattccag 3117601 atttcgtttt aatggagtag ccgcctgtgt caaaggtaat tcctttcccg actagtccga 3117661 cgacgtcttc ccattccttt ttgccctgat atttcaacac aatcattttc ggcggttcgg 3117721 tggagccttg gtttaccgca agtattccgc ccataccgag ctcttccatc tctgatttct 3117781 ccaatatctc acactcaaaa tcatatttcg ccgcaagctc ttcagcatac gaagcgaggt 3117841 cagtcgctgt cagcatgttt cccggcatat tcacaagcgt tctagccgaa tttgtccctt 3117901 gtccgtatgc ctggccgacg cgaagccctg cctgcacttc ctgtgtatct tcatctgtta 3117961 caacatacac ggcttcaatt tgtttgtcag gctcatttga tttatgctta taatcctgca 3118021 cctcatagga agcaagcagg cagctctcag ctaaagcatg agcggcatcg gctggaggca 3118081 cgtcttccga aataaacgta tcaagcagaa cagcagtttc ttgttttcga tctttatgaa 3118141 tggcttgaaa aacatgagca aaacgttcct tcgcctgttc aaacgaataa tttgcttctc 3118201 tccccaggcc aacgaaataa atccgtttca tacccgcaga agatggaggg aatacttttg 3118261 atacttgatt cggtttcgca gagacatcac cctcttttaa aagctgtgtc agatggcctt 3118321 cgagcatttc atcaatttcc aacgcttttc ctgtcagctg gcttttttga aaaagcccga 3118381 caacaagggt ttctgtatgc tctgattgtt gaaccgcata aaacatgagg cttacactcc 3118441 taacgtaatg ggtatttgta atgaacaatg gtataatagg aaaaacattc tttccactat 3118501 acttatttta acaaacaaca gtctaagact tgcttttttc ttttgaaaca cgaaggattt 3118561 ttcaaataga aaggatgtcg ccgatggaac ttttaacgaa ttttccttta ttatcaagcc 3118621 tggccgcaat tatttttgct caggtcatca aagtgcccat acagtttatc gtgtccagaa 3118681 aactggactg gtcgctggtc acaagcacag gcggcatgcc tagctctcac tccgcagcgg 3118741 tcactgcgct ttctacaggc gtagccttgg agcatggatt agactcctca ctctttgcgg 3118801 tttccgccat tttcgccgtc ataaccatgt ttgacgcaac tggcgtcaga cgtcacgccg 3118861 gtgagcaggc aacagtcatt aataagcttg ttattgattt taaccgtttc gtaaatgaag 3118921 cgaaggactt ccctaaggct gcagagaaag aaaagcaaaa aaagctgaaa gagcttctcg 3118981 gacatcagcc gatcgaagtc tttttcggag gattaacagg tattttactg acattggtac 3119041 tcgcttactt tttcatgtaa aaaaaacgct cctgctttcg ctggagcgtt ttattctttc 3119101 accgttttat attgatttct gaacacttgc aaagattttg tttcattgag cttctcaagc 3119161 tcatcctcgg taatctttcc cgttcccttt ttaatcacat atacatcaag ggtttttttg 3119221 ccccattcat tgtatacatc tttgactgtc tcaaagtaca gatcaaggcg gtttccctta 3119281 atagctgatc ctgtgtcggc cacaactccg agaccgtagt tcggaatgaa taaaattgtt 3119341 ccgatcggga aaacggacgg gtcagcagca accgtggaat ataaatcccg tttcactttc 3119401 acacctgaat atgtaagccc gtataatgga tcaccgggat ttttgcccgt cgactcagct 3119461 cctgctgtgt agcctgttgc tgttactctt tggactggat attcatccca atcaaatgcc 3119521 tcttctaacg gttttgtttt atcctcagcc gcggacgtgg tttgtgtttg tttctgctgc 3119581 aatgctttta atctcagtcc tgcatgcttc aagtgctttt cctgatgttc ctgcacccat 3119641 tttgacaagt ccttcgcttc aattcctgac actgataaaa atgtcgtgcc aaatgcaagc 3119701 agaaataaac aggtcatcag caaacgtctg atcatattca acatcattca cctctcctcc 3119761 gaatcattgt tcccaagtgg agagagcatt attcaaaatg gtgaatgagc tgaacgcata 3119821 aaaaaagctt tctttagaag aaagcggcat ttaaaacatt tgatatcctc tttttctaag 3119881 catgttgatc gctataccgg acacgatggc gccggccaaa ccgctgacta aaatcagcac 3119941 atcagcagcc gctaatgata agacacgatg aaacaggctg gcaaaggatt ctcccggcga 3120001 ctggacatag ctgatcagct tttctttgct gataatgaaa aggcatacaa ttggataaat 3120061 cacagccata atccaagaca ttctcagcag catgtttaat aagaaaccga ttccaaaaaa 3120121 caagacaaaa aacaaaacaa ttgagatgat tacgactggc agactaatca acctattcca 3120181 cccccctgcg ttgtttttag tgtaacgcgg gggctgaaat aaagtcaacg gctggaaaaa 3120241 gaatgactgt cttttcctgt cccctggcaa gacggacaag tctctgaacc gccgagaatc 3120301 aattgaaaat atcctttccc tgaacaaaat gggcatgcat gtgaagcggt tgtcgttgca 3120361 gttttcatct aatcatcacc ctttttctta attttctgat aatataccat atcaagctgt 3120421 caacaataaa gtcagatcat gtgacaaatc ttttgatgta agcggaaaca tacttgtttt 3120481 cctctcgttc tctttttatt ttggcgtttt ttaataaaga aaacccgctt ccgcgggttt 3120541 ttagaaaaac ttgaacttgc cttttttcaa tgtcagtccg agtccgccaa tcataaacag 3120601 tgagcggtta tcaatgactt ttttcataaa cgaagcgggc gtgcctttca gctttctgcc 3120661 ataaacaacc ccaaccgcgt tatgctcgcc aagagaagcc actgttccct taatgtccgg 3120721 cttgaattcc tcaagctctc cgcctttaat aagcctgcca aggtttttag cgaccgttat 3120781 gccctgctgc attgcaattt gcgcagtcgg cggatacggg cgctctgtat cttcattcat 3120841 aaacagcgag ctgtcgccga gaataaagac attgtcatgt cccggggcgc ggagatcagg 3120901 gttgactttg actcggccgc gcatattctc aaaaccggct tcctccacaa tcggatggcc 3120961 gcggacacct gccgcccata caacggtttg cgatttgatc tgctctggtt cttcatcttt 3121021 tttgccgact ctgactcctt ctggtgtaca ttcttgtaca gccgttccga tcttgaactc 3121081 aactccgttt tcctcaagat aatgtacggc gtaatcaaca agttccggat caaagcccgg 3121141 caaaacggtc ggcgctgctt ccacacaaat gatgcggaca aggcttctgt caacgtcata 3121201 ttccttacag agctccggca cgcgagcagc cagttcgcca agaaattcaa ttcccgtaaa 3121261 tccggcaccg ccaacaacga tcgttaacct gtccggccgt ttttccgctt ccgtattgta 3121321 agtcgcaaac tgcagctcaa tatgttcccg cagcaggcgc gacgtgttga tgttggcaat 3121381 cggaaacgca tattctttta agcctttaat gccgaacgtt tcaggcacgg cgccgagccc 3121441 gatgactaaa taatcgtact gcaattctcc attcgcaagc acaacttttt tctcatcaat 3121501 tttgattgcc tttacggtat cctgtacaaa attcacccgt gactggttga ttacatcttt 3121561 tatctgataa cggcagcggt catgatggag cgtacccgcg ctcgcttcat gcatccatgt 3121621 cgtttcataa tgataattgt gtttatttac aagcgtaatg tcagcatcat tcggcccgac 3121681 atacttcgtc agccttgtca ccgtcatcaa tccgccatat cctgcaccta aaatcacgat 3121741 tttgggctta ttcaatgcca tcacatccac cttctctttt tttgcttttg ttagacccat 3121801 aataaaatca tcatttgtgt tagcttcagc ttattggcgg gattttatga aatatattga 3121861 aaagtttttt gtgaagtcct tacccgtagc actattatca tgtttatccg gctggcccaa 3121921 gaaacattca gaaaaagatc atttcatttg gttattatcg tagcggcctg cggaaatatt 3121981 ttcaagaacg gatgggcacg ttagatcctt acgatttttt ctgctgactc gtcaatttga 3122041 acggcaatat ggtataatta ataacaattt tcatttagga ggcaattttc gtatgcgaga 3122101 ggatacaaag gtttatgata ttacaattat aggcggggga ccggtcggct tattcaccgc 3122161 tttttacggc gggatgagac aggcaagcgt caaaattatc gaaagcctgc ctcagctcgg 3122221 cggacagctt agcgccctat accctgagaa gtatatatat gatgtagcgg gattcccgaa 3122281 aatccgcgcg caagagctta tcaataacct aaaagagcaa atggcgaaat tcgaccaaac 3122341 catttgtctg gagcaagcgg ttgaatctgt tgagaaacaa gcggacggcg tgtttaagct 3122401 tgtaacaaat gaagaaaccc actactctaa aacggtcatc ataactgcag gaaacggcgc 3122461 attcaaaccg agaaagctgg aacttgaaaa tgccgagcag tatgaaggca aaaacctcca 3122521 ttacttcgtt gatgatctgc aaaaattcgc cggcagacgc gttgcgatcc ttggcggtgg 3122581 agattccgcg gttgactggg cgcttatgct tgagccaatc gcaaaagaag tatcgatcat 3122641 tcaccgccgc gacaagttcc gagcgcacga gcacagtgtg gaaaaccttc atgcgtcgaa 3122701 ggttaatgtc ctgacaccat tcgtccctgc ggagctgatc ggcgaagaca aaatcgaaca 3122761 gctagtgctt gaagaagtga aaggcgaccg caaagagatt ttagaaattg atgacttaat 3122821 cgtcaactac ggtttcgttt catctcttgg accgatcaaa aactggggcc tggacatcga 3122881 gaaaaattcc attgtcgtga aatcaacaat ggaaacaaat atcgaaggct tctttgcagc 3122941 aggtgacatt tgtacatacg aaggaaaagt caacctgatt gccagcggct tcggcgaggc 3123001 accgacagca gtgaacaacg ccaaggctta catggacccg aaagcccgcg tacagcctct 3123061 tcactcaaca agtctttttg aaaataaata ataaaaaaag gagcttgtgt ctgcgacaca 3123121 gctccttttt tatttgaaga tatttatata attcaatgca gttcctacaa ccagcgcaat 3123181 cacaagggct gcgactaccc agatcattgc cataataatg cggtcctgaa tcttttggga 3123241 cttcggtgtt ttttcttcgt tttgggccat cttattcgct cctttcccat gtccatgcca 3123301 taaagaaagc ctggtgctga acgaccaagc tttgctgaac gtatatcatt cgcgttttga 3123361 tccgctctct aagaccattc gttaaaacta tgatacctaa actcaccctg catgacaagc 3123421 ttcggcactt gcaccacacc tgccagcaaa tcataatgtt tgacatccta aataaaacag 3123481 agtacattat ataaggcgaa catttcatat attatacttt taaatattcg tttttaggag 3123541 tgaaaaccat ggaaaacgta tttgattacg aagatattca gctaattcct gcaaaatgca 3123601 ttgtgaatag ccgttcagaa tgtgatacat ccgtacgttt aggcggacat acatttaaat 3123661 tgcccgtcgt ccctgccaat atgcagacga ttatagatga aaaactagcg atttcattag 3123721 ccgaaaatgg ctacttttat gtgatgcacc gatttgagcc tgagacacga attgatttta 3123781 ttaaagatat gaacgcacgc gggttattct cttctatcag cgtgggcgtc aaagatgagg 3123841 agtatgaatt tgtccgccag ctggcagaag aaaatctgac tcctgaatac gtgacaattg 3123901 acattgctca cgggcactca aatgctgtca ttgaaatgat ccagcacctt aaaaaacatt 3123961 tgccggacag ctttgttatt gctggcaatg tcggaacgcc ggaagcggtc agagagcttg 3124021 aaaatgcggg agcggatgcc actaaagtcg gcatcggacc gggaaaagta tgtattacga 3124081 aaatcaaaac aggcttcggc acaggcggct ggcaattagc agcgctgcgc tggtgtgcca 3124141 aggctgccag caaaccgatt atcgcggatg gcggcatccg cacccatggc gacatcgcaa 3124201 aatcaatccg attcggcgca acgatggtca tgatcggttc actatttgcc ggacacgaag 3124261 aatcgccagg ccaaacgatc gaaaaagacg gaaagcttta caaggagtac ttcggctcag 3124321 cctctgaatt ccaaaaaggc gaaaagaaaa atgtcgaagg caaaaaaatg cacgtggcgc 3124381 ataaaggctc aatcaaggat acactgattg aaatggagca ggatcttcaa tcttctattt 3124441 cttatgcagg cggaacaaag cttaacgcca tccgcaatgt ggattatgtg attgtgaaga 3124501 attccatttt taatggggat aaatattaat cataaaaaaa cgccaagtca gcggttctcc 3124561 gcttgagttg gcgttttctg ctacttcttc agcaaagtaa gcttatattt gctttttgag 3124621 tttatcttcc atcagttctg ccatttgttt tgcatttgga ttttcttcat tttgcaactg 3124681 ttcaatgacg ttcatataat ccgtttcatt tcggttctgg cttaatttat atgccgcttg 3124741 aatgtcttcc accttaatct taaatccaac aatacctttc aattcacttt ctaagagttt 3124801 tggagaaagc ttatcccata acacaggatt gtcacgatgt ttttcgtatt tctccaacat 3124861 gattgttaat tcttctgcta attcatcttt ctctaacata cttgcttttc catacatgtg 3124921 gacagcctga taattccacg tcggaacatt ttcgcgcgaa taccaggaag aagaaatata 3124981 agcgtgcggt ccctgaaaca tcacaagcac atcttcacag gcttcaaacg ttctccactg 3125041 aggatttcca taagcgaaat gccccgtaat atagtaatga tcgtcttttt tattgaatcc 3125101 taacggcaaa tgtgtggcaa ttggttttcc ttgttctgtt gtgacaaccg taccaaagga 3125161 gttttcttgt acaaaattcc aaatttcttc agcatttgtg actttaaaat attttggaat 3125221 atacatcatc atccaccctt cgaaaaatat tatatgagtg ttttagccat gattaaatcc 3125281 gtttgttctt catcacccat ataaaatgag tgggcgccgg tctgaacaaa ccccattttc 3125341 ttataaaagg caatggcatt ttcatttttt tcccacacac ctagccaaat gttcttttta 3125401 ttacgttcca gcgcaatttc tatcgcttta ttcagcagat gtttgccaag cccatgtttt 3125461 tgaaagctgt tctttatata aattctctcg atttcaagtg attcagcacc catttcttca 3125521 gactgagcat catcgatatt gacctttaca tatccagcga tttcatgatc aaagtaaata 3125581 aaaaagaatt gcgaagacat attagataac tctttttcca gctgctcagt gttaaatgcg 3125641 ctttctaaat aggctttcat attttcaggt gagttctgtt ctttaaaagt gtcattgaat 3125701 gtttcaatac tcaattgttg aagtgtttgt aaatcttccc ggctgcattt tttcattttt 3125761 acactcattg ttcggattca gcccctttat ttaaaattca attgtcttgt gtccctttta 3125821 tatatttaaa cacggaacac atactgacct tgttaccatt ccaaaaatct tcttcatcac 3125881 caactcccta tcgtgatttt gttgtaaatg caataaaata tactccgcat taaatatatc 3125941 gtaactttgc tgtatttaca acaaaaatca aacaacaaag cagcgtttct cttgccgaag 3126001 ttcccggaac tctctgcatc atttccccat aataaaaacg cctcccttaa cgatgattta 3126061 tcgctaagaa aagcgtcagt aatagttgct atccgttttt agtgcttagc actcttcagg 3126121 cttgcctgca ttcgttgctg ttctgaacga agaaccgcag ccgcatgaag cgatggcgtt 3126181 tggattgtcg atggtgaagc cgccgccgag catggattgt ttataatcaa tcacggtgcc 3126241 gttcatgatg tcaaggcttt ctttgtcaac tagaacagtg atgccgtgct gatcaaacac 3126301 actgtctgat tcactctttt catgctcaaa gcccatgccg taagaaagtc cgctgcagcc 3126361 gccgcctttg acgcctacac gcagaaacgc gttttcttct tcatgctctt tcatcatatc 3126421 ttttatatgc aaagctgctg cttctgtaat tgttaccggg ttgctcatca ttatgaacct 3126481 ccttttaaaa accggttgct gtcttttatt ataaacatga tcgttccaat tctcaaacaa 3126541 ggtgttttac aagaaataga caccctcaca aacggtttca gccggccctg tcatcattac 3126601 atggccgtta tctttccagt ttatcaccaa atccccgcct gctaaatgca ccgtgatgtc 3126661 ttgatttcgc tttgatacgc cgtttaatac agatgcgact gccgctgcac atgctcctgt 3126721 cccgcatgcc tgagtaatcc ctgatccccg ttcccagacg cggaaatgca attcttgttc 3126781 attcacggtt tcaacgaatt ccacattgat gccttccgga aatctcggat ctttctcaat 3126841 caccggcccc agtgtcgtta agggtgcctg ttcaatgtct gcgatcggaa aaacgatatg 3126901 cggatttccc attgaaacgg cagtgcctgt tagttctact tcaccaaatg ccatcgtttc 3126961 attgattgtg tgctcttccc cgccgtcaag cataggaagc tcggattttg tcaagcgcgg 3127021 ttcgcccata tcgacagtga ccacattcac ttttccgttt tcgacttgaa cctccgcttt 3127081 cacaagcccg gagagagttt caatcagaaa agatgtttcc tcaaccagct tatgctcata 3127141 tgcgtatttt gcgacgcagc gcaggccgtt gccgcagttt ttcccttcag acccgtcatt 3127201 attaaaaatc cgcattttaa caggcgcttg gtctgatggg catatcagga tcattccgtc 3127261 ggatccgatc cctgtataaa cagaagaaac ctgaattgca atctctgaca gtttttcttc 3127321 tggaagctgt tcttcaaatt gattcacata aatataactg tttcccaggc cgtgcatttt 3127381 ggtaaatcga aatgagttca taggtgcctc caactttttt tctttttctt agtataaaag 3127441 ctattataag cggacacaat acaattatcc cccgtttttc atacataaaa gctccttgca 3127501 ctgacgcaag gagcttttat cgtttatata aacatgccgg caatggctgc gctgagcaga 3127561 ttggctaatg ttcctgcaag aacagccttc aggccgagac gtgcgatatc tgaacggcgg 3127621 ctgggcgcta aaccgccaag cgtaccaagc ataatcgcaa ttgatgaaaa attggcgaat 3127681 ccgcataacg cgaaactgat aatggtagca gttttcttag aaaactcgcc gatgtgcgaa 3127741 ccgaagttag aataagcgac aaactcattc agcaccaatt tctggccgat atagcttccc 3127801 gcctgcaatg cttcatgcca aggcacgcca atcaaaaagg cgataggaga aaacacatag 3127861 ccgagaatgg attctaatgt tacgcctttt aaaccgaaca agccgaaagc cccgccgaga 3127921 ataccgttta ctacagcgat taacgcaaca aacgcaagca gcatcgcccc aacatttaac 3127981 gcaatttgca gtcctgttga cgctcccttt gcagctgcgt caatgacatt ggctgcgcct 3128041 tcgccttcat ccattttgaa atcgcttttt acggtttgcg ttttttccgt ttcgggtata 3128101 atcaatttac caaagactag tccagctgga gcagccataa agctggccgc cagcaagtac 3128161 tcaatcggaa taccgagaag cgcgtaccca aacaaggtag atcccgcaac tgccgataga 3128221 ccgctcgtca taatcgtaaa caactcagag cgcgtcagcc cggcaatcag gggtttgatc 3128281 actaacggag attctgattg tcctacaaaa atattggcag cagccgccag agattccgtt 3128341 ttgcttgttc caaggagctt cgacaatccg ccgccaatga cacggaaaac gagctgcatg 3128401 attttcaaat gatataaaac tgcaatcagt gctgagaaga aaatgataac gggcagtaca 3128461 cttaatgcaa atgccggact gtctccgacc tttagaagcg gtccaaaaat aaaactgatg 3128521 ccttcattcg catagtcaat cagaagctgt acacggcttg aaaaccataa aaaaacagcg 3128581 cgtcccgctt cccatttcaa cacgatgtat ccaaacgcca cctgtgtgca taaaccaacg 3128641 atgacggttc ttatcttaat attgcttttc ttttctgaaa ataaaaacgc gatagcaatg 3128701 atcgcaactg cgcccagcag cccccacaga acattcatga atactcgtac acctcttaaa 3128761 ttttatttaa aaaaatatct tttatacgat aacaataata ttttttgatg tctacacatt 3128821 tttttagttc ttttgtacgg caaaataaaa aagggcctgt ccaggccctt ttctttaaaa 3128881 cattggattt tcttcaataa aggtatatat attctcaaca agctcagcag gcgtttcacc 3128941 catgacgact tctccgttta ccagagcgaa aagcgattcc atacatgtcc cgcagtagct 3129001 taagcagcca tattcaagga catcaaggtt gggatccttc tccaaaatcg cccgggcttc 3129061 ctgagagccg tgagccagat tgctgacaca aaattcaatc attggattca tgcggtttca 3129121 cctcacatat gtccattatc gcgaattttt cactattcgt caaagacaac ggatgattca 3129181 aaatttatta tcgtaacata ttatttctca aataacgttt tactaatttg tgttttcagg 3129241 ctaaattgta ggttattttg aaactattat tgtgatttta gatcaaattc gatataattc 3129301 tagatgttat tttacatagt tcgtattttc ttcaatgtat ctatcatact cttcggatta 3129361 aaggggaatt caaatgaaaa aattggtctt gatcggcgga ggttacggga acatgcgcgt 3129421 tcttcatcgc ttattgccaa accagctgcc tgatgatgtt tcaatcacgt taattgacag 3129481 aaatccttat cactgcttga aaacagaata ttatgccctt gccgcaggca caatttctga 3129541 ccatcatatc agagtgtcat tcccagagca ccctcgcctg gatgtccaat acggtgatat 3129601 cacatcaatt gatattgtac aaaaacaagt gctgttccaa gatcgtgaac cgatttctta 3129661 cgatgacgcc ataatcgggc tcggctgtga ggataaatat cacaacgtgc cgggagcgcc 3129721 tgaattcacc tacagtattc aaaccatcga tcagtcccgc gaaacctacc aaaagctgaa 3129781 taatctgagc gctaatgcca ccgtcgccat tgtcggagcg ggcttaagcg gcgttgagct 3129841 tgcaagtgaa ttgagagaaa gccgtgatga cctgaacatt attttgttcg accgcggtaa 3129901 tctcatttta tcaagctttc ccgagcgttt aagcaaatat gtgcaaaaat ggttcgaaga 3129961 gcacggtgtc cgcattatta acagggcaaa tatcacaaaa gtagaagaag gcgttgtgta 3130021 taaccacgat gatccgattt ctgcagacgc catcgtgtgg acagccggca tccagccaaa 3130081 caaagtcgtc agagacttag atgtggagaa ggacgcacaa gggcgtattg tattaacgcc 3130141 tcatcataat cttccaggtg atgaacatct gtacgttgtc ggcgattgcg ccagtcttcc 3130201 tcatgcaccg agcgcccagc tggcagaggc tcaagcagag cagattgtcc aaatcttgca 3130261 aaaacgctgg aatggagaag ccctgcctga atcaatgccg cagtttaagc tgaaaggcgt 3130321 cctcggttca ctcggaaaaa aagccggctt cgggcttgtt gctgaccgtc cgctgatcgg 3130381 ccgtgttccg cgtatgctga aatccggctt gctgtggatg tataaacacc ataacggtta 3130441 atgatagaga agaaccgctg atcaagtcag cggttttctg tatacccatg cttctccatt 3130501 tcctcataaa cgtcttttaa ttttggattg ccttcaccga caattttgtc ttctacaagc 3130561 acaagcggat aaaaatactc gtcatttctg attttttccg caagctcttt cgcatgttca 3130621 ttgtcaggcg gctcatgaat atcgatgtac tgcatctcaa aaggctgatt tggatatttt 3130681 cttttcagcg cagcctcaag ccactcgtat gtatccttgg ctgtcggcat atttacacag 3130741 ctcgcacaaa cgttttctgc cccgtacacg cttagcatga ctggtttcat cacttgtaga 3130801 cgcccccttc tcctatgtaa gtcctttctt ttaagtatac agagcctaag ggcgttttta 3130861 tagaaaaaaa ccgtttttgt gttgaagtct gaatgtgcta taatagggaa agcaactttg 3130921 caaaccaaac aatagatttt tattgttaca ctgaatataa tggttttatg acgacgaaag 3130981 gagcgaatgt catgactgaa gttgaaatga aagaacaggt gcaggaagta ctggacaaac 3131041 ttcgtccgtt tttacttcgt gacggcggtg actgtgagct tgtagacgta gatgaaggta 3131101 tcgttaagct tcgtcttcta ggcgcatgcg gcagctgccc aagttcaaca attacgttga 3131161 aagccggaat tgagcgcgct cttcttgaag aagtgccggg tgtcgttgaa gtagaacaag 3131221 tcttttaata aagcagccag gctgatattt gatcagcctg gcttttttat tagagatgtt 3131281 gatcaaacca tgagctgata taattcaggc gcttgatccg ctgtcttggg tgtccggtgc 3131341 gtgataaatt gtgcgatgca ttcggaaaac ggacaagctt ggtttccttg cccatttttt 3131401 tcagagcgat aaacagctgc tccgcctgct cgatcgggca tcggtcatcc cgctcgccat 3131461 gcagtatcaa aagcggtgtc tccacgtttg ctgcgtattt taaaggagac cggtcccaga 3131521 gcttttctgt gtcctcaaac atgtcatgct caagctgcca gtctgtaaag aaatagccga 3131581 tatcactgac gccgtgaaag ctgatccaat ttgatatcga gcgctgggta acggcagctt 3131641 taaagcggtt cgtctgcccg acgatccagt tggtcataaa acctccgtag cttccgcccg 3131701 tgacaccgag ccgcttagga tcaatatgcg gatctcgttt gatagcctca tccacagcct 3131761 gcatcacatc gtcataatcc tttcccccat aatctcctct gaccgcattc acaaattcct 3131821 gcccgtagcc gtggcttcct ctcggattga tataaacgac cgcgtatcct ttcgccgcca 3131881 gcacctgaaa ctcatgaaaa tatgtatgtc cgtacatcat atgcggaccg ccgtgtatgt 3131941 taagaataag tggatatgtt gtctcacctt ccatttgtgc aggcctcatc agccagccgt 3132001 tcaccatcac gccgtcttct gtagcatatt gaatctcttc aggtattgat atcgtatgct 3132061 ccctgacaaa cttgtcattc gcgccagtca gctgtttctc ttcctgtcca agcgggatac 3132121 tgtaaagctc actcggtctg tccggctttg tcacactggc aataaagtgc tgttcatcag 3132181 gtgaaagaga aaagctattg atgtactctt tttccagacg aatcggatac acaaggcctt 3132241 caatcgaaat ataatagatg cccgtactgc cttgatctgt gccgatgaca taaaaccctt 3132301 ggctgtcctt tgtccaaatc gggcgctgtt cagcaccacc gatcaatgaa tctccaatca 3132361 gcgcatccgc taaatgaacg tccagcatct cagtaagaca tgtgaggcgg ccttgttcga 3132421 tatcatagag ccacgccttt gagagcgtag cattcttata ttccttttca tttccaagca 3132481 aagcaagata ccttccgtct ggtgaaaatg agcttgatcc gaatgagccg cgatgaggtg 3132541 taacctgctt aagatctcca gactccagtg acattatgta aacatcatgc ggcttgctgg 3132601 catcatctgt ttcagttaaa ttagctgaga aaacaagcca tttgccgtca ggagaaaaag 3132661 caggatcacc atgatcagct ttgtgacttg tcagctcttt catctcaccc gactttacgc 3132721 tgacaagcac aagctgggca tacgcacctc tcgtcagccc tttgccgtcc cgtttgtagg 3132781 agaggccttg cacttcaaca ggttcatagc tgtcctgctc tgttttttct cggtcatcaa 3132841 tgctttcccc ctctcccaaa ctgacagtga ccagaatcga ttcaccgtcc ggggaccata 3132901 gcggctttga cacgccatat gggatatcag tcagttttct tgcttctccg ccttcagtgc 3132961 tcatgatata aagctgtgcc gcatcgcctt ctcgatcaga aataaaggca agcgtgcgcc 3133021 cgtccggaga ccatcttggg tcggtgcttc gcttttctcc atgtgtccaa ggaacagatc 3133081 ctcccgtttt cgtttcatag atccatatat ttgatgtata cgaatctttc tcttgattta 3133141 cttgtgattt tacatatgcg gcacgggtac cgtctggggc gtattgagga tcggtcacag 3133201 agacaatcgc tgtgatgtcg tctgcggtta tcagcttttt catattcatc tcctcctttt 3133261 tacatgtatt tcgtttttct aaataaaaac tcctttatct ccagcaaaaa aaagcgccct 3133321 ccgctgacgc tgaggaacgc ttggcatgat ctatacactt tttacttgat ataaaggatt 3133381 tcgctctatt atacttccct ctttcggaac ggtcaaagcg tctacttcac aatgagggaa 3133441 atgaagcgcg agctgttctt ttagctcttc tccctttcct ttttcggtca tgacgagaat 3133501 cgttgggcct gctccgctga gagccgttcc atatgcgccc ttcatctcgg cgacgtgctc 3133561 tacttttgac agctcaggca caagcatcgc ccggtacggc tgatggaaca tatccttctt 3133621 catgattttc ccgacaagcg gccaatcctt ggacatgatc gcagcaatga ggatattgct 3133681 gacagcactt gcttttacgg catcggcata tggaaactcc ttcggaagca cgtctctcgc 3133741 gtctcttgtc agcacttcat aaaaaggaat gacaacgact acgtcaatgt cagcattcgg 3133801 gacgcggatc atttgggtct cgtcatcctc atgcaggccg atcacaagtc cgccgacgag 3133861 agaagcgcca gcattgtccg ggtgtccttc ttctagactc gctaaatgca gcttgtccgc 3133921 ttcagacagc tttaagccgc ataattcatc agccagttca atggccgcta caatcgctgc 3133981 ggcgctgctg ccaaggccgc gtgcaagcgg gatgtcgctc cacaccttca catggacagg 3134041 aggcatttct tttccgtaca aatctgcggt ccgtttagcc acttggtaga tcaggttatc 3134101 tgtacccgcc ggaattccgg cgactgtttc tgtttcagcc tcaaaagacc atttgtcgct 3134161 ttcaaagacg gtcagcttca aatatctgct gagcgccatt ccgactgaat caaagccggg 3134221 gcctaggtta gctgtgcttc cgggaacagt gacagagaac agcatgtcgg cttcgttcat 3134281 acacgggccg ctccttttac atattcaagg atgctgtctt catcagtcgg caatgtgaca 3134341 ggcttgattt ctgaaatgtc gaccgctgtg ttcggatctt tcagtccgtt tcctgttaac 3134401 acagctacga ccttgctgcc tttcggaatt tctccggatt tcacctgttt cagcactcct 3134461 gcgatagacg cgcaagaacc tggttctgca aacacgcctt ctacacgggc gatcagctga 3134521 tatgcgtgaa ggatttcatc atcagtgact tcgtcaattt tcccattgga ttcctcggct 3134581 gcctttacag ctttgtccca gcttgccggg tttccgatac gaatggctgt cgctattgtt 3134641 tccggatttt caatcacttc attgcgcacg attgccgccg caccctcagc ttcaaagccg 3134701 cgcattttcg gaaggcctgt gccgtttttc tcatgatatt ccttgaagcc cttccagtac 3134761 gcagtgatgt ttccagcatt tccgaccggg atcgctaaaa catcaggcgc ttcccccagc 3134821 tgttcgcaca cttcgaaggc agcagttttt tggccttcaa tgcggtaagg gttgactgag 3134881 ttgacaaggg caatcggtga tttctcacag atggaacgga caattttaag cgcatcgtca 3134941 aagtttccgt caattgcgat aatctcggct ccgtacatga cagcttgagc gagttttcca 3135001 aatgcaattt ttccgttcgg gatgatgaca atgcatttca tgttagcacg ggctgcatat 3135061 gctgccgcag cagcggaagt gttacctgtt gacgcgcaca taatcgtgtc attgccttct 3135121 tcttttgcct ttgccacagc cataaccatt ccgcgatctt taaatgatcc cgtaggattg 3135181 acgccttccg ttttgacatg aagctcaatt ccgagctgct cagacagctt cggcaggtga 3135241 ataagaggtg tgtttccttc atgtaaagtt agcgccggtg tttgatctgt tacaggtaaa 3135301 aattctttat attgatggat aagtcctttc cacattagct ccaaccgttc ccttctacac 3135361 gatatgtgct tttgacttct tgaacgactt ccaaatcatt taggttttgc aggatatcac 3135421 tgaaatcagc ttctgatgta tgatgtgtga caattacgat ttcagctaac tcatcatggc 3135481 ctttaattgg cagctgaagg attttttcaa agctcacgcc ccgctctgag aacacagatg 3135541 taattttcga gaatgaacca acctcatctt ttacatgaat tcttaaaaac tgctgtgcat 3135601 aaatgtcaga cggcgatttc atgtttttct catattgcgg tccgacaaag ctgttgccgg 3135661 ttacacctag gcgcatattt ttcatgacag cgacgaggtc agaaacaacg gatgtcgctg 3135721 tcggcatgct tccggctccc ggcccgtaga acatcgtctc accgacagcc tcgccgtata 3135781 cataaacagc gttaaactca ttatgaacag cagaaagcgg atgatggtca ggaagcagtg 3135841 tcggctgtac gctgacctcg attttgctgc cgtcacgctg agcaatcccg atcagcttca 3135901 ttgtatagcc gaggcgtttg ctgaagctga tgtcctcgtc tgtaatttgg gagatcccct 3135961 ttactttgac gtcttccaga tccacgttca tcgagaagcc gaggcgcgcc aatatcgcca 3136021 ttttccgtgc ggcgtcaagc ccttccacgt cagaagtcgg atcagcttcg gcaaaaccga 3136081 gatcctgcgc ttccttgagc acttcctcgt atgggctttt ctctttgatc attttggtta 3136141 agataaagtt tgttgtgccg ttcacaattc ccatcatttt tgtaattcga tctgatgaga 3136201 ggccttcctc taacgtgcgc agaatcggaa tcccgccggc aacactggct tcaaagtaga 3136261 tatcgcatcc attttccttc gcttcggcaa gcagctcgga gccgtacaca gccattaagt 3136321 ccttgtttgc tgtgacaaca tgctttttcg atctcagcgc gtcgaccaaa tattgttttg 3136381 tctgttcaac gccgccgatc acctcgatga cgacatcaac atctggatca tcaatgacat 3136441 catacacttc tgtcgtgagc acttccttcg gcaaatctac ttctctcttt ttctctaaat 3136501 cttttacaag cacttttttt atcgtaaccg gacagccgac ctgatgcata agcttatcct 3136561 gatggtcttg aataatttta acgacaccgc ttccgacggt acctaaacct aaaagcccta 3136621 cacgaatcgc tttcaaaaaa actccacctt tcttttgatt gtcctcttgg aaaagacaat 3136681 tgttaactca acacagacat ataagttaca aacattatat aagcccgctc ctgttttgac 3136741 aagacatcat taggctgaat tttgcgaatg taaacgctta acgcattgat atgacaagat 3136801 tctttatttt ctaattattt ttgtcagatt ttctcctcac cttgagctgc ctttgccgag 3136861 ccagctgacg cgtggaacaa acagcttctg cgcccgcata ttcatgaatt cctgcgctgt 3136921 attgagaaat tgttcataac gcccacagtc attaagaatg aagtcaagct gttcttcaaa 3136981 ataatgcttt tctgattctg atgacatgta atagctttct acgatttcaa aataatgaag 3137041 cgggaaaagc agacggctgt ataaaaggcg tttcgaaaat gaagacagcg gtgtgacttg 3137101 ctcgtattcc tgtaaaaaga gaaagccctg ctgattaaaa tcttgtctgt gatgcaaaaa 3137161 cgtatgcctc atatattcag ccaaatcacg ggaagcgtgg tcaaacaccc aatccgccgg 3137221 aatcctgatc aatgattccg gtgaccatgt atgcctttcc atccgctgat ggcatatcgt 3137281 tcctgaatca gcggcttggg gcttgtcatc cagctcagtg tccactaaat attgtatcgc 3137341 gttttctgac agtcctaaat aatatggaaa tgattcgatc atttttttat cgaatggctc 3137401 atgcggaggg gtctgaacct ttctctgcca aaatgcttcc agctgatcaa ttcgttttcc 3137461 ccacagatcc ttccactggc cgattcttcc ggccgccttc acctcatatg gatatcctcg 3137521 gccttttcgg tgaaattccg caagctccgc tccaatggag aacgccctgt ttgaataagg 3137581 gggggccgcc ttcagcagag cgtacgtttt tccctcatgt tcaaatgtca gttcaccttc 3137641 ttttgtaaag ataaaaaccg aaacgtatgg gtcactttgt tcttgtaaat actgactcat 3137701 gtaataaagc tccgccagct ctgtttctga gaattgggaa acggggacaa tcagaaagta 3137761 tgaattaggc gtctgaaagc attgatatgt gtgctggtac atggaaagct gcctgatgtg 3137821 aatgccgtat ttttctttta ttgtaccttt caccatgatc acctgcctgt tgaattaggg 3137881 ctcatcacat cgtagtcata cacagccgga attatgaata catattttaa tccgaagaag 3137941 gcgcaagaaa aagtcgtaaa cttctcaagc attttgtata aactagtaaa aaagattggg 3138001 tgaagctgat gtcagaaaac gaacaattca gtcagatgga agctaaagca agagcacgga 3138061 tgaaggagcg cggcgttgag gtatcagaca ttgccgagct tgtctttttt ctgcagaaaa 3138121 aatatcatcc ggatttaacc attgatgaat gcacgctgaa cgtcaatcgt gttctcgcaa 3138181 aacgcgaggt gcaaaacgcg attttaacgg gcattgaatt ggatgttctt gctgagcaga 3138241 aaaaattgtc tgaaccgctg caaacgatgc tggaaataga tgaaagccta tatggagtag 3138301 atgaagttct ggcattttcc attgtgaaca tttacggatc gatcgggttt acgaactacg 3138361 gttacatcga caaagaaaaa cccggaatcc ttaaacgatt gaatgataaa tcaaccggtg 3138421 aatgccatac ctttttagat gacatcgtcg gagcgatttc cgccgcggct tcaagcagac 3138481 ttgctcaccg cgcgcggcat acagaataag ggcacccttt tagggcgccc ttttttcaaa 3138541 tgtatggaat ccattcagtc agagagtcaa tggcgtgagt cggtttttcc atatcgtctg 3138601 tcatatgttc tcttttcgtt acgcctgtgt gaacgagcag cgtatccata cccgcgttaa 3138661 tgccggccat aatatcagtg gcgtagttgt cgccgaccat gagtgtttca gacacatctg 3138721 tgccgagaac gcgcatcgcc tgctccataa taattgattc cggcttgccg ataaatacag 3138781 gctgtacacc tgtagatacg gttaacaccg atgtcagtga gccgtttccc ggcaggagcc 3138841 ctctttcagt cggaatcgca atatctccgt tagtggaaat aaagcgggcg ccatttctga 3138901 ttgccaggca gccaacagca aatttttcgt atgtaatgga acggtcgatg ccaacaacga 3138961 caaaatccgc gttttctccg ccaaatgtca ggccgttttc ttcaatcgcc tggcggattc 3139021 cttcctcccc aatcacatac acagacgcgt cttttttctg ctgtgcaatg tgctgggcag 3139081 ttgccatgct ggtcgtgaag acctgctctt ctgttgccgg aatatcaaaa gacacgagct 3139141 tgtccgctac ctgcttcggt gtgcgcgaag agttgtttgt cacgaaaaga taaggaacgc 3139201 cgcgatcttt cagcgttctg acaaattcac acgcctcctc gattttttcc gtgccattgt 3139261 acatcgttcc gtctaaatca attaaatacc ctttatatgt tttcatatcc aacactcctg 3139321 tggctttcca gttgttattt aaacgcggaa acaggtccta gctctgtttc caaatagctt 3139381 ctgatccgtt tcgggaagtc ctgaagagct gtttgatgcg ccttgatcag cctgtaaagc 3139441 tcgccgctgt cagcgagcag atactgttga accaacgttt tgcggtaggc gatcaatttt 3139501 ttgagctcat caccctcttt ttccgtgaca actttctcat caacaagtat atccataatg 3139561 tcgtcatagc tgcccgggtc ccgcataata aagccgtcaa tcatgtcatt gcctgtatcc 3139621 aaaatgcatt cgattaacag atggcctata cgctgaagtg ccaattcccc gatttcagac 3139681 tgccagtctg tttgtgagtc aaatagcgcc agctggtgct cgaagaaccc tagtgttttt 3139741 tcgattttgc ttctgtcaac aaaatacatg acagcatccc ctttgtgtat atttattttc 3139801 tgatccgttt caagacaaaa tacgcacagc cgaaattgca gtattcgtaa atatattcat 3139861 ctaatgtgct gattttcgtt tcgaaggttg ccttttgatt ctggtcgtca aagaagccct 3139921 tgagccttaa ctgaccgtat ccccagtctc ccacaatata atcgtattta tttaatatat 3139981 cggagtagcg ggctttaaaa gcctcttcgt tgaagccgtc tttgaaattg tgcaccaatt 3140041 caaattcggc attttgaata agaatcatga tctcacctct tttttcactc attcctatca 3140101 taattcattg ccccgtcccc atcaattgct aaagaataaa tcatgcgatt tggctaccct 3140161 acacatgagg agggattgat aaatgaaacg aaccgctgtc agcctctgcc tgctgaccgg 3140221 actattatcc gggtgcggag gcgcaggatt ggataatgcc caaaatgtcc ggaatcagac 3140281 gcagaatcaa accaaaccca ttcatgtgtc ggaccgcaac gaggctttta acaggcataa 3140341 tgagaacgaa caatttggct atgtccgcta tcaaaaagaa caatttgacg gagaacagca 3140401 gaaaacgccg gtgatgaacc gggaagaaac cgctcacatg atatcaagtt taacggttca 3140461 gctcccccat attcaagatg ctgcgacatt ggtgactgac cgagaagcgc ttgtcgtata 3140521 caaaaccgat tctaaaaacc gggagctgac cgccgatcag gtgaaaaaaa cagcggcttc 3140581 tgtgataccg cgatactatc acgtgtatat ttccgataat ccaaaccata tgcaatccgt 3140641 cgaaaattac agcaatctcg gctctggttc aagggatatt agagagatca tgtcggggac 3140701 gattcaagaa atgaaaacct ccccgcaagg aagccctgtc tcagagaatg aaaatgccaa 3140761 tggagaaacg cgtcaggaca tgaaaatcga taggaatgac aaaaacgcca gatgatctgg 3140821 cgttttggca ttatgcttgt gcttgacgct ttttagatgc ttcgtttact tgttcatccg 3140881 catggtaaga ggaacggaca agcggaccgg cttcacaatg gctgaagcct ttttgcatcg 3140941 cgatttcttt taattctgca aattcatcag gatggtagta tttttggact ttcaagtgtt 3141001 tcttcgtcgg ctgcagatat tggccgattg ccataatatc cacgttgttc gccaagaggt 3141061 cgtccattac ttcaataatc tcttcttttg tttcgccgag tccgatcatg atacttgatt 3141121 ttgtcggaat gtcaggctgc atttccttcg cacggcgcaa aaattccaat gaacggtcgt 3141181 acgtcgcacg cgcgcggact cttggcgtca ggcggcgaac cgtttcgata ttgtgattca 3141241 ggatgtctgg gcgtgtatcc atcaaggttt ttaggttatc gtagtttccg cccatatcag 3141301 acggcagcac ctcaattgtt gtgaacgggc tttttctgcg gatcgcacgg acagtttccg 3141361 cgaaaatgcc tgccccgcca tctttctgat cgtcacgcgc aacagccgta atgaccgcgt 3141421 gtttcaaatt cataagcgcg actgaatccg ctacgcgttc cggctcttgc agatcaagct 3141481 cagttggaag gcctgttttg acagcacaga aacggcatgc tcttgtacaa acagaaccta 3141541 aaatcataaa tgtcgctgta cgtctgaccg cccagcattc atgaatattc ggacactttg 3141601 cttcttcgca tacggtatgc aggttgtttt cccgcatgag ttttttgagc cctgtatagt 3141661 tttcatttgt atttaattta attttaagcc attcgggctt tctgaggtgt tcgtctttct 3141721 ttgccaattc ccatcatctc caatatccaa tatactcaat ttctgacacg aaacattctg 3141781 aaaacgagaa aggtgcaggt tttagttctg caacaaaaat aatgtttttc taactaaaga 3141841 aagtcttttc tttagacact ttaacatagg aaaaatttct cgacaaggga agatgattac 3141901 tgacattttt aagccgggtt gccgcaaact atgtgtattc aatatgaaag gagattattt 3141961 tgtgaaagtt ttgttatccg ctcttcttct ccttttgttt gcatttgagc cttctgcgtc 3142021 tggaaaaaaa ctttcagatc cagtgctgtc gaaacggatg gaattatatc ataaaatcga 3142081 agctgtgacg cagatccctt ggtatgcgct cgccgctgtt gatcaatacg aagaaaacgt 3142141 gcggagcaac cggaaagatc tgcctgaaaa ggcgggaatc atcagcatct atatacccga 3142201 tgatatctgg agcgggcctg aaaacccgaa tccgaaagac gatgcgccgt taagcattaa 3142261 agtgtttgac ggaatcggaa tggatggcga tggagacggg aaagccgagg tcagcaacga 3142321 tgaagatatc ttgtatacgt tcagccaata cttactgtcg tatggcacag atgaagacaa 3142381 catccggatc gggctttgga attattaccg gcgtgatcag acagtgggga ttatatctga 3142441 attcatgaag ctgtttaaag cctacggcca tattgatctg ggcgagcatg cattcccgct 3142501 tccgatcaga accgattaca gctaccgaag cacgtgggga gatgcccgcg gcttcggtgg 3142561 aaggcggatt catgaaggta cggatatctt tgcccattac ggccttcctg tcaaatccac 3142621 atgttacggc gtagttgaaa tgaagggctg gaaccgcttc ggaggatgga gaatcggcat 3142681 cagggacatt aacaatacgt atcattattt tgcccatctc aatgggtttg ccaaagggat 3142741 taaaacagga caaatcgttg agcctggcca agtgatcgga tcagtcggca gctccggata 3142801 cggcccgccg ggaaccgccg ggaagttccc gccgcatctg cactatggca tgtacaaaga 3142861 taacggaaga accgaatggt catttgatcc atacccgcat ttgagggcgt gggagcgata 3142921 tgaataccaa aaaaagaagt aacaaaaagc cgcctcttca acaggcggct tatttgctgc 3142981 ttttttcttt ttttgaatcg gcaccgtttt ctttgctgct cggaagctgg acagaaggcg 3143041 tgacacccga gccgccgctt ccattataaa actgcggcac ttcgccctgc actgctttaa 3143101 tcgatacagg aacattattt gtgacgacag cggttttgct ggcaaatgga atgatgacct 3143161 tcactttaat ttcgacaaag atgctgatat caataagtgc gttatttatg ccatacggct 3143221 tgattttggt tttgacatct gtaaaagcgt caccgattaa attgaaccgg accgggattt 3143281 tcggcccgag gtttccaaga aggctgttgc cggttacctg tcccagcgga atgttgatca 3143341 taatgttttc actggcgccg ctgtgtccgg tatgggtttc catctctttc aaatgagcct 3143401 gaagctgctt tgtcactttt gttttcacac tgtttacaac ctgtgtatta aaatcgattg 3143461 tcgttaagtt tccgttttca tcagaattca tttgaaacat atctttcata ttttcactgt 3143521 cagacatata gtcctcaatc gaatcctgga tcacctctgt cgctatacgc ttcgtttcca 3143581 tctcgccgat gtccattaaa acaggtttga tcgagccatt gatcatccaa aggctgaccg 3143641 ttgttgacag gataaaaaag acaacggaca ggagcatcac gtaacggaaa ggcaaaggtc 3143701 ctctcttgcg aaaagggccg cgatatcttg gcaagaaaat ccccccttac atatcacaat 3143761 gtatgcttgt aagaggggac atagtaatag ccggggccaa tttattttat ttcatcattt 3143821 ttaaaagcgc ttctctgccg ctcatgccga ctttgatgcc aagatcttcc gcagcgtacg 3143881 tgacggattc taaaggtgcg tctaacagct ggtcaatggt gcggacacca actgcgcgtc 3143941 ccgccacgat gccgcgctcc tttaattttt cattcagcag cgccacatca agcgcgccgc 3144001 acataatgta tccgtgatca ttggcgacgg ccataaaatt cgttttggga agctttactg 3144061 tcacagctgt aaaaggctgt ccttctatca tgatcggtgt caggtttacc acgtcaacca 3144121 ctcccttcat tcatcacttt atgatgaagg gcacagcttg ttgtgggctg actgccttat 3144181 tgtgcaagct tccaagcaag cagatcccgc aaaaattccg gcataaaata ttctttttct 3144241 gcagcgtcgc gaatcaacgg aaacagtttg ccgagcgtaa acatatcaag caccgcaacg 3144301 gagtattgtt tatgtttttc aatatcttcc ccgttcagtg tgatccgagt gacgtgggtg 3144361 atcccgtcat cgagccgttt cgtttctacc tcaacgccgg catacaccat tttccccatc 3144421 acttctccgc ggaagccgag tcctttgatc cggagctgct ccatttgttc ggaagcggca 3144481 tggacaatgg tttccttcag ttcttctccc gtcaggcgga cagccaccgg gttgatcgga 3144541 tgcggacaga tgcggtgcag atccagcttt gtcacaggac ctgcttttag cggaccgaga 3144601 atgacacctg aattgaccat actgatgtcc gtctcgcacc attcctttaa ggcgtatgcc 3144661 aaaagcaaag gcagctctga ttcttcaaac cacttcacct cagcatcttg tgcaagctct 3144721 gcaacggcat cggacagttt ctcctcggct tcacgttctt tttcattgag aaacgcttta 3144781 gtttctgcgg attctcctgt ccattccgcc atgttctgca cagaagccgt tttgctgttg 3144841 atgcttcgct gtacgctgtc caccgtgatt tctacacagc cgacataatg cccgtatttc 3144901 tcggcgctgg ccagcagtac cccattaacc acttgtccat cttcgagcaa atgatgggta 3144961 tgtgattcga ggattacatc aatctcaggc accgcttcag ccactgcttg atcatcaaga 3145021 atgcctaaat gtgacagcag aacgataata tcagcctgcc ctttcacttc cagaatggtt 3145081 tcctttatgc tttcaagggc atccgtaact gtccatccca gcttgtcata tacaggataa 3145141 tacggcacag ttacacctaa gaaagcaatg gacataccgt ttttcaatga tttgatatgg 3145201 taaggcaccg cccaggacgg acggtttcca tttttatcaa acaggttaga gacgatgaca 3145261 ggaaattcag catgatcata taaggcagca agctcttcat gcggaagcgt aatcccttcg 3145321 ttattgccga tcgccgctcc atcaatgtga aggcggttta agagatcgac attcgctttt 3145381 ccgaatgtcg cctctgtcac gaattgaaaa cgatcaagat gatcgccaat atcaaaaacg 3145441 agcgtctctt cgccgtctga ctgatgctct tttcttttct gctcgatata atctacaatt 3145501 ttcggccagt tttcaaaatg gctgtgcaaa tcatttgtat gatataagcg gagcttctcc 3145561 ttcataatat ctctccctaa tcgttcagct gaaaatgcct tcataaatga gctggcagcc 3145621 gatcaaaatc aatacgatcc gcatgatcat aacgatcgtt ttcgtctgca tttttctgtt 3145681 gatggcggcg ccaagctttc cgccgaacca agcgccgggc acaagcgcga gggcgtacag 3145741 ccaattgacg tgcccggaaa tcatatgtga aacagaccct gtcatagaag acaggaaaat 3145801 aataaacatg gacgttgcca ccgcaacctt cggcggaaac agaaataaca gcatcatcgc 3145861 cggaaccatc agtgatccgc cgcctatacc gaaaagtccg cctaaaaaac cgacaacaaa 3145921 ggcaatggca ataccgacag aggcctgata tgagtacgta taaggctcac cggcatcatc 3145981 ctgaaatgtc cggataattc ctttgtgcgc tttgttgatt ggccgggctt tcgctttcag 3146041 cattaaggat aatgaaatca gaatcataaa aatgccaaac caaacggaaa acgagtttga 3146101 attgaacagc tttgacacgt aagccccgat catgctgccg ggacccgaac cgataaagaa 3146161 aatgagtccg ctcttataat caactgtttt atatttaata taagccaaag ttgaagaaag 3146221 gcccgtaaaa ataatgacca aaagcgaagt tccaatcgca acctgcggcg tcacatcctg 3146281 aaacagctgc gtcactgtgc ttaaaaacat cagagatggc acaatgacaa ttccgccgcc 3146341 aagcccgatc agacttccta ccgtacctgc gattaatccc agtacgacca aaatcacaaa 3146401 cgacatcaat caaaacctct tttctaaaat aaatcgagct gtctcggagc aagtccgctg 3146461 tactcgatat caagcagttc aagcatctgc ttgccattat ccgcagcgtc accgccggaa 3146521 ttgttgttga acaggacaaa aacatcctta cattgctgct gcaattcatt caggtgcttt 3146581 ttccaatcct ccagctcctg ttggttgtag cggtataagt acctgacctc ccgccagttt 3146641 ttcccgccat caggcttcat ccagccctgc ttgttgcgtc cgtgaaacct gacgagcgtt 3146701 ttgttttcat cggtcgcgcg caacacggtc ggaacgctgc cttctccgat ttgcggttca 3146761 tcacagacac tgtgaatcca gccttccgct ttcataaatg aaagcgtctg ctcataaaat 3146821 ggcggcgaga accaggaacg gtttctgaat tcaagcgcgc aaggaatatc tcccatttgg 3146881 tgcttacacc atctcaaata ggcgacattc tccttcttgc agtcaaacca cggcggaaat 3146941 tgaaacagca ccatggcgag cttattgcta tgtaaatatg gcgttaaaga caccttaaac 3147001 gcatcaaaca tctcctcttt tgagtcaaag ggaatttcgc cgcgctgatg ccctgtcatg 3147061 ccctgatatg ctttcacgat aaattggaag gtttcgggcg tttccttcac ccacttttca 3147121 ttattgcgcg ccggctgaat cgcgtaaaag ctcgcgtcta attccacgat cggaaaatgg 3147181 gaggaatagg cctgcaattt tttctggctg gccgttttcg gcggatagat gctgtcatga 3147241 tccccccatc ccgtcagtcc gatataaatc acactcattc acctctcttc cagtttatca 3147301 cacgtgtttt caggtttcct cggaaatgct gttcatatgg cgggaaaatg cctcacgcaa 3147361 atgctgatat tgttcctcat tcgtatctaa aaacgcctct tctcttgagg aaggaatgtg 3147421 ctgatattca ataggcgcct gaaactgctc actcgtaaaa tcgtacacca caccattgat 3147481 gctgttataa aaatgccagc tctcatcgac tcttgttttg aaaatcgtgc cgccgaaatg 3147541 gtcttgaatc accaatgccg tcacgccgca ttggccgcat gacgggcatt cttccgtcca 3147601 tttagagctc gaatggcgcg accaggattg cttaagtatg tatttgacat gctccattgc 3147661 ctccgcctcc tttaaaaaaa gataccacgt tgatgagatt ttaaaaacta gaacggagga 3147721 aatcaaaaaa cccggcggta aaatccgccg ggcttacgaa ggaacgacca gagctccgtc 3147781 aatttcagtg actttttccc catcattgta cacgcaccgg cctttgctgt aagtggccga 3147841 aatgctgcag ggaaatgtat gtccttcgta aatgcttttt ttatgctttg caaacatcga 3147901 ttctcttgta acagtgtacg gctccatgct gacgagcacg aaatctgcat cacaccccgc 3147961 ctcaagccgc ccttttttct gaaggccgaa tcgttttgca ggggccgccg ctgtccattc 3148021 tgcgatggtt tcaaatggaa tctgatgctc aagcgccagt tccagcattc ctaataaagt 3148081 gaactgcccg ccgctgattc cgccccatga taaaaacatg ttatcctccc gcttcaagga 3148141 tggacggcaa ggggaatggt ctgaggaaac catgtcaatg tccccggcaa tgagcgtctc 3148201 gatcagcgtc tcttttgatt gccgtgaccg gagcggaggc gcgcattttg cgacagagcc 3148261 cctttgccgt aaatcgtcat ggctgaacaa gacataatgc ggacatgttt caaccgaaac 3148321 atcaagacct tcctgtttcg cctctctgat cagccggacc gctttcgccg tgctgatatg 3148381 gacaaaatga accggacagc ctgtcacctt cgcatactga atcgtgcgat acaccgcttc 3148441 aacttctgct tcctccgggc gggaggcggc gtacgcatcc gcatccacct ttcctttatt 3148501 ggccaaaacc atctgcaagt agcttgtgat cgcgtcgctt tccgcgtgga gagcgaggat 3148561 ttttcctgca gccgcgattt ctgccatgcc tttgagcaat gtccgttcat caacagagcg 3148621 gaactcatca gtgcctgact ttgataaaaa cgctttaaac ccgatcgctc ccgcttcagc 3148681 catcggacgg atgtcctcga tatggcctgg cacaaggccg ccccatagcg caaaatccac 3148741 ggcagatttt tgcctgccta gctcagcttt tgcgagaaga tgctctgccg tcacggttga 3148801 tggaatacag ttgagcggca tatcaaaata ggtagtgcaa ccgcctgcgg ccatcatttg 3148861 agaacctgtt tcaaacccct cccaatcctc cctgcccggt tcattaaaat gaacatggca 3148921 atctatcaca ccaggaaaca cgtatttccc gtctgcctgg atgatttccg tcccgcttgc 3148981 ttcaatgtca gaacctatct cggcaatgac accgttttga actacaatat cagcttctat 3149041 aacgccatct ggcgtaactg ccttcgcacc ttttatcacc atatcgtaag ccatattgat 3149101 ccccccatgt caggatgacg attttccatg tcagtttatg taacacaacc agttctattt 3149161 tcaacagttt actgctacta tgatcgtatt acatcagcaa aaccgctaga attcctattg 3149221 aaaattattc accttaacca atgtttttat agaaaaggag aatgcgctat gaatattctt 3149281 gatgtgatga aaataccggc ttttgaaaac gccaatttaa tcgctggaaa agcaggaggg 3149341 gaaagagagg ttcagcatgt caatatgatg gacgctccgg atatcgtaga ctttttgcat 3149401 aagaatgaat tgctcgtcac caccgcctat cacctgaagg atcacccgca tcaattatct 3149461 gaactgattc ggcaaatggc aaaacgcggc tgcgcgggcc tcggcattaa aacaaagcgc 3149521 tatctggaag atatcccgaa ggaaatcatc gaactggccg attcatatgc gtttccgatc 3149581 attgagcttc cggaacacat ccgactcggc gatattgtga atgccacact cagccatatt 3149641 ctcgatatgc gttctaacga gctgcagcaa gccatttacg cgcacaaaaa attcacaaac 3149701 cacattatga gcggcaaggg gctgcaatcc ctcctcaaaa aggtgtcaga catccttcag 3149761 cttcccgtgc tgctgcttga ccagcatgcc aaaatgctgt ctgcgtctca tcagatttca 3149821 gttgagaccg aaaagctgaa aggcaccctg aataccgtat ccgggccatt tttcacttgt 3149881 ttctctacaa tctcagatca gaaaacatat tctgtcctgc ctatttataa tcacgaaaaa 3149941 aactgcggct acctgctgat acccgacatg gtgcaggcag gcgacaaagg attgatcctc 3150001 acgattgaac aagcggccaa cgtcatttcc tttgaactgc tgaaggaaaa tgcgctgaag 3150061 cagttcagcc ggcgggcccg caatgagttt ttcaacaatt ttattgagcg gaccttttct 3150121 tcagatgacg aaatcaaaaa ccgggcgaaa gaattcaagc tgcgctggga tcaaaaatac 3150181 atgtgcatcg ccggcaaact cgatcgcaat gacgaatcaa tcagctttac agaaaatcag 3150241 ctcgcttccg acagcgtatt cgaatttctt gaaggtgaat tatcagcctt cccgtttcca 3150301 cctcacttct ttatgaaagg aaatgtcggc attattctaa tcgaggcgac agacagctgg 3150361 agtgaaatgc acgcctcggt gatcagcttt ttagaacagt ttcaaacaca ggtcagcgct 3150421 caatttaaac gaaccgtgtc ctttggcatc agcaatatct gccaaaagct cattgatgtt 3150481 cccgacgctt tcacagaagc ttctgatgct ctgcaatcgg ggcatttgtc aagaagcacc 3150541 gcatttatcc aggtgtatca cgccaaagat gtgcctgagc ttctgcgctt gctcccagtt 3150601 gaggatttga agaaatttta caactccacg cttcagagcc tcgctgaaaa acagcaggag 3150661 gatcaaagcc tgcttcatac gctttccgtc tatttagaga cacactgcca aatttcagag 3150721 acggcaaagc gtctgtacgt tcatcgcaat acggtcatat accgccttga aaaatgcgaa 3150781 gagcttctgg ggaaaagctt aaaagatcct gaaacaacga tgcgtttgcg gcttgcatta 3150841 cgtatgcagc ggctgatcag ctaaagtttg ttacattttc ttacaaaacg aatcgttttt 3150901 cgtcactttc agcaatcaca cctgtctttt tcagctactg tatccaatga cacccctcga 3150961 ccggaacgat attatgttac taaagttcac atacagggag ggactatagt gaaaaaaaga 3151021 tcgtttaagg tgtttacact tagcctgcag catgtgctcg ccatgtatgc aggtgcgatt 3151081 ttggtgcccc tgcttgtcgg cagggcgctg aatgtaacaa ctgaacagct gtcctaccta 3151141 ttggcgattg acctgttaac atgcggcgtc gctacgcttt tgcaaacctt gcgcggaaca 3151201 tacatcggca tcgggcttcc cgtcatgctt ggcagttcat ttgtggccgt caccccaatg 3151261 attgcaatcg gcagcaatta cggcattcac gcgatttatg gttccatcat tgcggccggt 3151321 gtgttcatct ttttgtttgc gcgttttttc ggcaagctga ctgtgttatt tcctcctgtc 3151381 gtaacaggta ccgttgtgac cttgatcggc ctttcacttg ttccgacagg tgtgaaaaat 3151441 atggctggcg gcgaaaaaat aaacggcagc gccaaccccg aatacggttc gctcgaaaac 3151501 cttcttctct ctgtcggtgt ccttgttctg atcttagtcc tcaaccgctt tctcaaagga 3151561 tttgcccgaa cactgtccgt tctgatcggc atcgccgccg gaacagcggc agcagcgatc 3151621 atgggcaaag tcagcttttc ttctgttaca gaagcaccgt tcttccaaat cccgaagcct 3151681 ttttacttcg gagcccctgc gtttgaaatc ggtccgatct taacgatgct gatcgtcgga 3151741 atcgtcatta ttgtggaatc aaccggcgtt ttttacgcaa tcggaaagat atgcggcaga 3151801 cctttaactg acaaagatct cgtcaaaggc tatcgagcgg aaggaatcgc cattctcatc 3151861 ggcgggctgt tcaatgcctt tccttataat acctttgcgc aaaacgccgg cttattgcag 3151921 ctgaccaaag tgaaaacaag aaacatcgtc gttaccgcag gctgtatcct tgtctgtctc 3151981 ggactgattc cgaagattgc cgcccttgca tctgccgttc ctgctgctgt acttggcggc 3152041 gcgaccgtcg tcatgttcgg catggtgatt gcctccggcg tcaaaatgct cagcacagcg 3152101 gatctcaaaa atcaatacca cctcctgacc atcgcatgct caatcgcact cggcatcggc 3152161 gccagcacgg cccccgggat ttttgctgaa ttccccgctc cgatccggat tctggtcagt 3152221 gacggcacca tcaccggaag cctaaccgcc atctttttga atctattttt cagcttgcgc 3152281 gacaaaaaag aattaacagc acagcaaaca gaacttccgg tattagaaca tacactcgca 3152341 ttagaaaaag aggtgtaaaa aagatgaagg aacagcacaa tgccttacag ctaatgatgc 3152401 tggggcttca gcacatgctt gccatgtatg cgggagccat tctcgttccg ttgatcgtcg 3152461 gagcagcgat cgggctgaat gcggggcagc tgacgtattt aatcgcgatt gatttgttta 3152521 tgtgcggggc ggcaactctt ttgcagctct ggagaaaccg atatttcggc atcggccttc 3152581 ccgttgtgct cggatgcacg tttaccgcag tcggcccgat gatttccatc ggaagcactt 3152641 acggtgtccc agcgatatat ggtgccatta tcgccgcagg actgattgtc gtcttagccg 3152701 cgggcttctt cgggaagctt gtccgttttt ttccgcctgt cgtaaccgga tcagtcgtca 3152761 tgatcatcgg catcagcctg attccaacgg caatgaataa cctggccgga ggtgaaggaa 3152821 gcaaagaatt cggctcactc gacaacgtgc tcctcgggtt tggcgtcaca gcttttatct 3152881 tattgctgtt ttatttcttt aaaggcttta tccgctccat agcgatttta ctcggtctta 3152941 tcgcaggaac agcggctgca tatttcatgg gaaaggtcga tttttctgag gttttggagg 3153001 cgtcttggct tcatgttccg tctctgtttt atttcggacc gccaaccttt gagctgccgg 3153061 ctgttgtcac gatgcttctc gttgcaattg tcagcctcgt tgaatcgaca ggcgtttatt 3153121 ttgccctcgc tgatatcaca aaccgcaggc tgtcggagaa ggatctggaa aaaggctacc 3153181 gggcagaagg ccttgcgatt ttgctgggcg gcttatttaa cgcgtttccc tatacagctt 3153241 tctcgcagaa tgtcggcatc gttcagctct caaagatgaa aagtgtcaac gtcatcgcca 3153301 tcacaggaat catactggtc gcgatcgggc tggttccaaa agcagcggcc ctgacaacag 3153361 tgatccccac cccagttctc ggcggcgcaa tgatcgtcat gttcggcatg gtcatttctt 3153421 acgggatcaa aatgctatcc agcgttgacc ttgattcgca aggcaacctg ctgattatcg 3153481 cctcttccgt cagcttgggg cttggcgcta caacagttcc cgcgttgttt tcatctcttt 3153541 cgggcgcggc ctctgtcttg gcaggaagcg gaattgtgat cggcagtttg acggccattg 3153601 cactgcacgc tttttttcaa accaaacagc cgaatagcgc agacataaaa acgtaaagga 3153661 agatgccaat gttcacaatg gatgacctga accaaatgga cacacaaaca ctgacagaca 3153721 cacttggctc tatttttgaa cactcttcat ggattgcgga gagatccgca gcactacggc 3153781 cgttttcgtc cctttctgat cttcaccgca aaatgactgg cattgtaaaa gctgcggatc 3153841 gcgagacaca gcttgattta atcaaaaagc atccccggct cggaacaaag aaaacaatga 3153901 gcgatgactc ggtacgagag cagcagaacg cagggctcgg caaattagaa cagcaggaat 3153961 acgaggagtt tctcatgctg aatgaacact attatgatcg cttcggcttt ccttttattt 3154021 tagcggtgaa gggaaagacg aaacaggaca ttcaccaagc cctgctggca aggcttgaga 3154081 gcgaacgaga aacggagttc cagcaggccc ttatagaaat ttaccgaatc gcccgctttc 3154141 gtctggctga catcatcact gaaaaaggag agacgcaaat gaaaagaacc atgtcttatg 3154201 gcaaaggaaa tgtatttgca taccgaacgt atttaaaacc gctcactgga gtgaagcaaa 3154261 tcccggaatc atcttttgcc ggaagagata ataccgttgt cggcgttgat gtgacatgcg 3154321 aaattggcgg agaagccttc ctgccatcat ttacagacgg agacaacact ctcgtcgtgg 3154381 caacggattc aatgaaaaac tttatccagc gccatctcgc atcctatgaa ggaacgacaa 3154441 ccgaggggtt cctacactat gtagctcacc gatttttaga tacctattct catatggaca 3154501 cgatcactct gactggcgaa gacattccgt ttgaagcaat gcctgcatac gaggagaaag 3154561 agctcagcac aagccgcctc gtcttcagaa gatcgcgtaa tgaacgaagc cgctctgtgc 3154621 tgaaagcaga acgaagcggg aataccataa cgattacaga gcaatacagc gaaatcatgg 3154681 atcttcagct cgtcaaggtg agcggcaact ccttcgtcgg cttcatccgg gacgaatata 3154741 cgactctccc ggaagacggc aaccgcccgc tgtttgtcta tttaaacatc agctggcaat 3154801 atgaaaatac aaatgactca tacgcttctg atccagcacg ctacgttgcg gctgaacaag 3154861 tccgcgactt agcgagcacc gtttttcacg agctcgaaac cccttcaatc caaaacctaa 3154921 tctatcatat cggctgcaga atattagcga ggttcccgca gctcactgat gtcagcttcc 3154981 aatctcaaaa tcacacgtgg gatacggttg tcgaagaaat cccgggctca aaaggaaaag 3155041 tctacaccga accgcgcccg ccatacggtt tccaacattt taccgtgaca agagaagacg 3155101 ccgagaaaga aaaacagaaa gccgctgaaa aatgtcggag cctgaaagcc tgatgggaaa 3155161 actgacaacc catattttag atttaacctg cggcaaacca gcggcgaacg taaaaattgg 3155221 attgaagcgg ctgggcgaaa gtattatgaa agaggtatac actaacaatg acggcagggt 3155281 cgatgtccct ctgctggctg gtgaagagct gatgtcagga gagtatgtga tggaatttca 3155341 tgcaggagac tattttgcga gtaaaaacat gaacgcagcc gatcagccgt ttttaaccat 3155401 cgtcaccgtc cgttttcagc tagcagatcc agatgcacat tatcatatcc cgctcttgct 3155461 gtcgccgttt ggttatcagg tgtatagggg gagttaagaa ggaagcccgc ctcaccggcg 3155521 ggcttctttt tgcacttcaa ttaacttttg atcctaggac agtacttgaa gtgatcccca 3155581 cacttagtga aacaacagct agaataaaca ttcacctata tttttcagga taattgccta 3155641 cgagaaaaat accctgtagt cctttcattt ataaatcgag gtttcaaact aataagtcag 3155701 ctcttagcag ccgagctccc ttctccaatc ctataaacag accgcgtttt ttctcgaaaa 3155761 aatactctga agacaattgc tgcgttttta atagttttga taacgcgttc tctcttacac 3155821 ctttagacaa aatattcatt ttttcttttt tagacttaaa tctatgtcga aaataatcgt 3155881 tggcatatct tatcctatct ccactaaagg aggtgacatt atgggattct acaattctgg 3155941 tggatacagt ggaaactctg gttactcaaa cggtttcggg agctccttcg ctttgatcgt 3156001 ggtgctattc attttgttga tcattgttgg agcagctatc tttaattatt aagtttaact 3156061 ttccttgcct ccgccgtatc caacacctcc ctgtccgaca gacgccataa gaagttttta 3156121 tggcgtcttt gctatgtgtt cactaatctt tttgtaatcc agaagctgtc aagttctacg 3156181 agatttatcg tgtgttttcc cacaacgctt ctgcgtcttg atcgcgctgt ctgactgagg 3156241 ctaaaaaagt ccggctttta aaagccggac tcccgtctac ccccgttcaa ctctcttcta 3156301 atcctgcaag ctgaccgcat aatcccgcca tacccggtac accggcacaa attccccgcc 3156361 agcccttctt ctatatcttt gtcagaaggt tgaggggttt cccgaaacaa tgctttaagc 3156421 gcaatgatca ttcccggcgt acagtagccg cattggaagc cgccttcttc caggaaagcg 3156481 gtttgacaca tatccagctc ttctttttga agcccctcga tggttgtgat ggaatggccg 3156541 tctgcttgat aggccatcgt catgcacgca ttggccagtt ttccgtcgat taaaatagag 3156601 caggctccgc agcggccgat tccgcaggac acctttgtcc cggtcagctg aaattccttt 3156661 ctaagcaggt cactcagatg tgtcgtagga acggcagcaa cctcccacgc ctgaccattc 3156721 acggtcatcc ggaactgttc cttttttaca ggaaatggcc cggcctcttt tatgtccatt 3156781 gcttcagccc ctttctgtcg atcgcttcaa gcaactcttc tcttgaaatt ggcagcttgt 3156841 ttatccagca tccgaccgca tcatgtactg cctttacaat cgccggagtg atggcgattg 3156901 ttccgatttc accaacaccg cgcggtccat atacgtctcc cttcattaag tcttctattg 3156961 caatcagctt catgtcagga acatctttga ttccgggaat caaatagtga tcgagatttt 3157021 ccgcagcata acggccatcc gtcattttcg cttcctccat cagtgtgtag ccgagtgcca 3157081 tggcagcgcc gccttcaatt tgacctcgat atccctgcgg actgacaacc ggacctgccg 3157141 caatagcgtg ctcacaatct atcaatttga catcgcctgt taacagatct acctccacct 3157201 caacggcagc cgctccaaat gagtagagga aatggccgcc caccacagga tcaggcgttg 3157261 ttggaaagtc aaaggccgtt tcctctgcca aagggccttt ttcagccagc tccttatacg 3157321 tcaccacgag cgcctttgtg tttttgtcac gcaagcctgc agcgccggga ataagatttt 3157381 ccgctgaaca gccgctccat tctgccgccc gttttttcaa ctgagctaga aacggcttct 3157441 tcaaacgctg gatcgcgtgc cacaccatgc ttgtgccgcg ggatgctgtg gaggagcctg 3157501 acttcggcac ttttgcggta tccccaataa caatggaaat atcctctgcg gcacaaccca 3157561 gctcctccat gacaatctgt tcaatcgctg ctagaatccc ctgtccgcat tcttcaaatc 3157621 caaacgaagc agtgattttg ccttcactcg aaagagacaa acggcctcct gccgcatcca 3157681 ttcggccaaa ccccagcccg ccgccgtgca ttgtaattgc cgctcccgtg cctctttgca 3157741 gatacccgca gttccggctt gtttttttaa gaatgggaga tttagatatg gcattcaaca 3157801 cctgtgccgc tccgtcagtt ggtgcaattc gatgctcaag cggccccaag tcatgcggtt 3157861 ttctgatatt ttttcttctc agctcgagcg ggtcgatgcc aagcatgccg ctgagacgat 3157921 cgagatgggt ttcgagtgca aatgtgattt ggttgccgcc aaagccccga aattcccccg 3157981 ccaccccgtt gttcgtaaat actgatattc cttcagtccg gatattcgga atacggtacg 3158041 gccccgcggc atgctcgaca gaaaaatcaa gaacagccgg tccgagcgta gcgtaagcgc 3158101 ctgtgtccgc cacaattttc acgtcgtgcg ccaatagatt tcccgaatga tctgcacccg 3158161 tttttatcgt aatcttcatc ggatggcgct taatgccaga acgtacagat tcctttcgtg 3158221 tctgatgaat tttgacaggg cgtccgcttt tcagggccaa aagcgcagca tacggctgaa 3158281 tattcagctc atccttccct ccgaacgagc cgcccatcgg acttgacaca attctgatct 3158341 tctcttcagg aatatcaaaa atacgggcaa gctggaaacg gtctttatag ccgtgctggg 3158401 ttcctgcata catcgtaaaa cccccgtcgt cttccggaac ggctacacct ccctccgttt 3158461 ccatatacgt atgcatctgc cgcggcagct cataggtttc ttcaaagact gtgtcagatg 3158521 cttgaaaccc ttcttccaca tcaccgtttg aaaaaaatgc gcggtgcagg atattcccgt 3158581 cctcatgcag tctttgcgca ttcggccgaa gcgctttttc tggtgaatcc atgacttcca 3158641 gctctttata ctcaacttga atcagctcca gcgccgcttc cgcgatttct tccgtttccg 3158701 cagcaactgc ggcgatcgca tccccgacat accgcaccct gtcctcacat aaaaccggct 3158761 gatcagggat gacaatgcca aatcggttta agccgggaac gtctttatgt gtgacgacgg 3158821 cctgcacgcc ttccattttc tcagctttta tggtgcaaac cgacacaatc tctgcatgag 3158881 gataagcact tctcagcacc ttgccataca gcattcctgg aaagctgaga tcggtcatat 3158941 atttcaattc ccctgtgacc ttaccccttc catccggcct gactcttgac ggtttgttga 3159001 tgatcattta ttcccctccc tcagccatca gctctgccat gatgacgttg gcagcggctt 3159061 tttttctgta tgccgctgac ataaaaacat ctgaggaaaa cggcagctca tggataagtg 3159121 ttttgtacag ctcatgcggg tcccaccctg gtgccatcca tttcgcttcg ctgtccaata 3159181 atctcctagg agtgatatcg gcatggccag cggcgaggcg aatgctgccg tctttcaaaa 3159241 aacgtccagc tgcaacagca gccgctccgg taaaagcctg gcgccttcca agcttgtgat 3159301 aaaatacacg ctctccctcc gcccgcggga tgatgacacg cgtgacgata gccgttctaa 3159361 agtcttcctc actgagccaa gcgccaagcg gcagcctgat tagctccttt tgatatacga 3159421 taagctcagc accaagcaca agcagaagcg gaatgaaatc accgatttta ctcgctatgt 3159481 tgccgccaat cgtggcacgg ctgcgaatcc ccggtgcagc gacagcggaa gcagcgtcac 3159541 tgaaacagct aagcgctctc ttaatcaaag ggttctttct gcattcattc agtgatgtga 3159601 gccccccgat cgacacgtgg gtgtcactgg tgctgatccc tcgcatttcg tcaatccctt 3159661 caaggctgac aaggtgctgt ttcggtagag ttcctttgtc ccactgaagc tgaaggagcg 3159721 tgcttcccga tgcggcacac acatccggag caagcttctc taaaagcgaa taggcctcat 3159781 caagcgctgc cggtctccat aattgaatat tcatccttgc ttttgtcact tggccgttca 3159841 agacatcgcc ctccttacca tgtcatattc ctcgggtgta tcaatatcgt ccaactcacc 3159901 gctatccttt gcctccaaaa ccgctcctgc tccaagctgt ccgcttttca ggagcctgcg 3159961 agccccttca tctcccttta atccctttac ataaggaaaa catgtcgacg agaagtagat 3160021 tggcggggtg aacgccccta aaaacgatga cacggcaaat gactcaggag ccagagccac 3160081 aagggcattg agatgatcga cggaaagctg aggctggtcg gctaacaaaa tgacaatgcc 3160141 gtccgccccc atgctttctg cttttctcac cccgctgctg actgaatgcc cctgaccctt 3160201 ttctgcgtct tggcaaacgt gcaggctcca gcgtttttga aaaggcggag cgtgatacgg 3160261 cgctcctatc cactcaaggg aggcatgttc tgtccgctcg acgaccagca cgtgatcaag 3160321 gcgggacgac agagcagttt tcaaggaaag tgagcctatg ttttctcctt ttagcggcaa 3160381 agccagcttg ttttgtccca ttcttctgct tttgccggca gcgagaaaca cgccgatcag 3160441 ataggggctt ctcatacaac cgccacccgt tttcttgttt gaatgatttc tgcaactaca 3160501 cttaccgcaa tttcctcggg accttccgca ccgattttca gcccgaccgg actgtaaaag 3160561 tgagacggag gatgttttcc gctcagcagc cgtttcgtgc ggtttgccga acccaacagt 3160621 ccaatataat ggaggttttg agaaaataag aagttgatga tcgtttgatc gtgctgataa 3160681 tgatgggttg ccacaacagc tgcatcatgc ggaaaaaatt gaaattcgct aagcatttgt 3160741 tccggaaaag cggtgatcag ctgatccgct tttggaaaaa gagaggatgt acaataagcg 3160801 ggccgccaat ccgtcacgat aacagaaaac cctgtgtcag ccgccaaatt ggccagcggt 3160861 acattatccg gtcccgcccc aaacagaatg agacgcggct tcggttcaat tcgctgaata 3160921 aacatgttag tggtttgatc gaaatgcggt aaatgaagcg ttgaaacagt acgttgaata 3160981 tcttgcagag gcgcgtccgg ccagttccca aaatgtccgt tctccgtcag aaataaataa 3161041 tgggaggatt caatctttat aacggaagtg acagctttgc ctgaatgaag gcagtccctc 3161101 actttctcat agtgccgcct tttttcctga gtgattcgct ctgcatgaac atgaataatg 3161161 ccattgcacc cggctcccat gccccaagaa agatcgtcct ccgaccgcat gtcgtaggga 3161221 atcagcgttg atgtgagctg atcgcccagc gcactgattc tttggaatac atcttcttcc 3161281 acacacccgc cgctcagcaa gccaatccgt ctgccttttt tcttaaagag catagaggcg 3161341 cctgcttttc gatacgcgga gccttcaact tgaacaattg tcgccagtac agcctcctcc 3161401 tggtcttcca ggagcgcatc taacatcgtg tgaaaattcc ccaatgccgc atcctcctct 3161461 cgaaaattgc cgtgagaaac aactagttca gcgtgatttt ataggtaact tgtataaaga 3161521 atagacgatg gaagaaaaaa tgactcatga tttgtcagaa aatgaaacac atagaaagag 3161581 gatttgtaaa aagagtcaaa cgaagaaaat cagattggag aaaacacgaa atcatatcgt 3161641 taaaaagctt gcggagttcc gcaagctttt ctttacaccg ctgcctggcg gccagcgttt 3161701 tcatacacat ccagcgctgc ttggagcgct tttcctgctt cgattcctgc gttatgtctg 3161761 agaagcacag cctctaaccc ggcaagcacg aatagcacgt tttcttttct gcagctgtac 3161821 cccatcgtgc cgatcctcca gatcttccct gcaagcgggc cgaatgagct ggcgatttca 3161881 atgccgaatt gtgccagcag catgtcacgg acagactcgc cgtcaatgcc gccgggaatt 3161941 tcgacacagg tgacaacagg cattttgcag ctgtcatctc caaacaatct tagccccatt 3162001 gcctttatcc ctgctgctaa tgcggcttca tggtgccgat gccgctcgaa acgcgtctca 3162061 agaccttctt caagcaccag tctgactccc tcacgtaagg cgtacagcat cgtcgtcgct 3162121 tctgtatgat gattgagccg tctttcgctc caataatcct caagctggct caaatcaaag 3162181 tagttgcttg taattggccg atttcccgaa agtgctgccc tgtcagcttg tgtcgcaatc 3162241 ccgcgttcca cctttttgcg agctgcaatc acgtccgcca cccgctcatt atatgtaatc 3162301 ggcgccattc ctgaaggcac agacaaacat ttttgcgttc cgccgatggc agcgtcaatc 3162361 ttccattcat cgactttaac ctcgcagccc ccaatcgttg cgactgcatc gacgataaac 3162421 aatgcatcct cggtgcggca ggcttcgccg atggctttca gcgggtgaat ccgtcctgtc 3162481 gatgtttctc catgcaccat ggccacaatt ttcggcttca ctttttttat ctcccgtatg 3162541 atgtcctccg ggtcaaaaac cgttccccat tcgcactcca gcatatgaac atttgcccca 3162601 tatcgctcgg cgatttcagt cagcaaataa ccgaaacggc cgtaaatggg aatgagcaca 3162661 tcatcttccg gctctatcac actagccagc actgcttcaa ttcccgcccg tgaagtgccg 3162721 tcaatcgggt atgcccagcg gttttttgtt tggaacagct cccgaagcat ctccatcgtt 3162781 tcattcataa tacctgtaaa cgccggatca aattggccga caaccggggt gctcattact 3162841 cttaatacac gcggatcaac ctcaacaggc cccggtgtca taatcgttct taacggggtg 3162901 cataattctc ttctgcctga cacagccatt cctcctttat cagtaagcca gtttgtataa 3162961 taaatcagtc agtgcgcgga cgccgatctc aagctgtctg gctgacgtat attccttcgg 3163021 tgagtggctg acgccgcctc ggctcggcac aaacagcata caagcaggat agcgccttcc 3163081 gatcatttgc gcgtcatgcc ctgctccgct caccatttcc tcacagctga agccgttttc 3163141 taatgctgtt tcaaaagccg cagccttcag cctttcgtcc atcggcacag gctctatccg 3163201 catatattca tcaatcacag cgcgaattcc tttttgtagg caaatgccgt tgatcaaagc 3163261 aaccatgtct tgatgaaact gttccagcac atgctgatgc tgatggcgaa tatcgattga 3163321 aaactggacg cggcccggta tgacattggc tacattgggc tctgccgtta tttttccgca 3163381 tgtcagacgg agctcatccg gcagctcatc cgaccgcagc agcagctcat gaatgatacg 3163441 gctgctggct gcgagcgggt ccttgcgcca tttcatggag gtggttcctg cgtgattgca 3163501 ttctccttcg agcgtgacga gatatcgtct ctgccccgca atacttgtca cgatgccgag 3163561 atcccggcct gacatttcca acgtcttccc ctgttcaata tgcagctcaa caaacgcgct 3163621 gatatctgtc ctatatgctg actgaaacac acctttgcca aaaccgctct catgcatcgc 3163681 tgtttggagg gagactcccg actcgtctct tggctctttt gcatcttgtt ctgaaaaaac 3163741 acccgtcata ttccccgacc cccaataggt cattggaaaa cggctgcctt cctcctcaca 3163801 taaggagacc gcctcgagcg ttttttttgg cgctccgtat gtttccttga gctgctttaa 3163861 cgcgagcatt gccgccagaa cgccataggc gccgtcgtat tttcctccat tgatgacagt 3163921 atcgatatgt gaaccggtta caatgacttc atccggagac tgggtgcccg aaagccttcc 3163981 aaacacattg ccgacatcgt cgaatcttgt ttcaagcccg aaagaagaca tttccgtttt 3164041 cacagcaagc tgtgcgtcca tccactcttt tgtgtataaa agcctcgtta cgccgccatc 3164101 cgcagacgca ccgtattggg cgagccattc aatataatct gtgatgctgt tttttactga 3164161 aagcttctgc ttttccatgt actcccccct ctggccgcta tggtgacttc attatagaag 3164221 gagcaacatg atagttcatt gacagattaa ccaaaaaaac gtttattttt tagccacagt 3164281 atccatccag caaccagata caccctacat gtcacaacta ttttgatgta aaggtcaaaa 3164341 gaaaacacgg taaggaagag agccagcaag agcgaaagag agggtcaaaa tgcctttcat 3164401 atgaacaagc taagctggag aggcgatgtt cgcggaacgg atgaaaacag aaatgccggc 3164461 agcccgcaaa aacaggacct aaagatatgg aaacaggaga tttccgcctc ctccaaaggg 3164521 actaatttac aattttaatg aaaaatatac aaaatgacac ttctatcctt tatttcaatt 3164581 ttagataata gatatgatct gataaaagga gggcaagtga tgacaaaaaa agcatggttt 3164641 ctgccgctcg tctgtgtatt actgatttcc ggatggcttg cgccagcagc ttcagcaagc 3164701 gcgcaaacca cattaagcct taatgaccga ttggcgtctt ccccttcagg aacgggaagc 3164761 cttctctcat tagccgcccc cgctgcaccc tatgctgaca cagataccta ttatgaaggg 3164821 gctgaaggta aaacaggaga ctcgctaaaa agcaccctgc accgtattat cagcggacac 3164881 acgatgctgt cctacagcga agtgtggaac gcgctgaaag aaacggatga agacccaaga 3164941 aatccgaata acgtcatcct gctctatacg aatgaatcgc gttccaaaaa cctgaacggc 3165001 ggcaatgtcg gcgattggaa ccgcgagcat gtctgggcga aatcccatgg cgattttggt 3165061 acgagcaagg gacctggtac tgatattcat catttgcgcc cggctgatgt tcaagttaac 3165121 agcgccagag gaaatatgga ttttgacaat ggcggcactg aatatgcgaa ggcacccgga 3165181 aattattatg acggcgattc atgggagccc cgcgatgatg tgaaaggcga tgttgcccgc 3165241 atgctgtttt acatggctgt ccgttacgag ggtgatgacg gctatcctga tcttgagctt 3165301 aatgataaga caggcaacgg ctcagctcct tatcatggca aacaatctgt cctgctcgaa 3165361 tggaataagc aggatccggt tgacgaccgc gagcggaaaa gaaatgaaat catttatgaa 3165421 aaatatcagc acaaccgcaa tccatttatc gaccaccctg aatgggcgga tgagatttgg 3165481 ccgtaagaaa aaggtgctcc ttttgaggag cacctttttc taatacacag cctcttccgt 3165541 ttccgcatcg aaaaagacga cgtggtccat tttcactgag agctggattg aatcgcctgc 3165601 atcgattcgc gtgtttccgt ccaggcggac cttgagccgc tcgtccccag ccatgacatg 3165661 cactatgagc tccgagccca gattttcatt cacttccacg ttcgcttgaa acactgaatc 3165721 aaacaactgg tcatttcctg tcatttgtgt gatgtgctcc ggccgtacac cggcaatcat 3165781 ctgttctccg gcatatccct tttccttcag ccgctttgct ttttcttcag gaatatgaag 3165841 ccggatcgaa gaatttgtga aaaacagctc gccatgctgc tgttctatga tgcctttcaa 3165901 aaagttcatt ccgggagagc caatgaagcc tgcgacaaac aaattggccg ggtaatgata 3165961 aatgtcatga ggtttcgcca cttgctgaat ttccccttca ttcatgacga caatccgatc 3166021 tcccattgtc attgcttcgg tctggtcatg cgtgacataa atgatcgttg cctctaatcg 3166081 ctggtgcagc ttgctgattt ctgtccgcat cgtcactctt agttttgcat ccagattaga 3166141 aagcggctcg tccattaaaa agaccttcgg ctccctcaca atcgacctgc caagcgccac 3166201 cctttgccgc tgcccgccgg agagcgcctt cggttttctc ttcagcaaat gttcaatttc 3166261 taaaattctg gctgccgcat gaacccgctc ggcaatttcc tgtttcgcca tctttctgag 3166321 ctttaatcca aacgccatat tatcaaaaac cgtcatatgc ggataaagcg catagttctg 3166381 gaataccatc gcaatatcac gttctttcgg cggaagatca ttgacccgct ccccatcaat 3166441 aagaagattt ccttcagaaa tgctttctaa tccagccacc atccgcagcg ttgttgattt 3166501 tccgcatcct gacggcccca ccagcaccaa aagctcctta tcctttacat ctaaatcaaa 3166561 gtccttcacg gttaattgtg agtgatatga ttttttgacg tgttcaaatg ttaatgaagc 3166621 catcagaaaa gtccccctat cttttgaccc gttatttcgt cactggaaac aacttggtct 3166681 ttctgttatt tttagagtaa tcgattccca tttttgctat atttctaaaa taaaaaatgt 3166741 aaatttgtat tataacgtca taatacatta taatataaat aataggttaa aaggaggcta 3166801 ccctttgtta aacaacggaa gttctacacc tttatacatt cagctaaaac aaatcatcac 3166861 tgatgacatc aaaaagggcg tgtattcccc aaccgccaag ctgcctaccg aaaacgagct 3166921 ttgcaccaag tataacgtca gccgcatcac cgtcaggaaa gccattctcg atttagtcga 3166981 agaaggctat ctgatcaggc agcagggaaa gggaacgttc gttaaaagcc ctaaattaaa 3167041 acgagagctg atcgctgtaa acggctactc ggaatttatg gaatcaaccg gcaaaaaacc 3167101 gaagcatcat gtgctgtccc atgacatcat tccagcgtca aaacccatcg ccgaaaagct 3167161 tcaaatccaa cccgagagcc ctgtggttga attaaaacgg attttatata atgatgatca 3167221 gcctctcacc tttgaagtga cgcattatcc gcttgatttg tttcccggca ttgatacctt 3167281 tattgctgac ggcgtctcca tgcatgatat tttgaaacag caatacaaag ttgtacccac 3167341 gcacaatacg aagctattaa acgttgtata tgcccaacag gaggaaagca aatacctgga 3167401 ttgtgatatc ggggatgcgc tgtttgaaat tgataaaacg gcttttacat caaacgacca 3167461 gccaatctat tgctcattgt ttttgatgca cacaaaccgt gtcactttta ccatcaacag 3167521 cccctacaca taacaggcat aaaaaacgag acactgctta tagtattctc gttttttcac 3167581 tgcttccccc gtcctccaag cgataaggat agccatagcc gaaagctccg tacacaccgc 3167641 aagttttcgc agccgtttca gcagcctggc gcaaagcata cgttatatcc tgcttcacgc 3167701 aaaaggcagt caaaaagcct gctataaaag aatctcccgc tccaagtgta tctattatat 3167761 cagcttccac aatcggctga tgatagactc gatcacccgc agacaggatt gctccttggc 3167821 cccctcgggt catacaaacc attttggctc cgtacccatg agctgttttg gcaagctcac 3167881 cgcattccga ctcactcaaa tcgcttcctg aaaaaaacgc atacgtcaca taaggacaga 3167941 ccctcctcaa ataatcatcc tcccgattgg ttgaaaaatc aaatgagacc gggaccagcc 3168001 cgcacagctg cggaagatcg ttctcaagcc tgctgtacac gctcgtatgc agcagatcat 3168061 gcccgctgat aaaagataca tctttctcct gaaacgcgag gcgaagccgg gactgaatgc 3168121 cgcctttatt tgatctgaca aaaatgcggt ccccctgttc atcaagggtg acaatcgcca 3168181 tcccgttttc tccgtgcgcc tggcggatat aatctgcatt gacctgctcc agcttgagaa 3168241 cgttcaacag atgcgccgcg gcttcgtcat tgccgacgat tccgatatag gaagactcat 3168301 gcccgagccg cttggcaagc acagcaacgt ttaaggcatt tcctcccggg taaaatgttt 3168361 cttgatcctg gtagtaatct acaacattat ctccaaccgc aatcaatttc atagcgcttc 3168421 ctcctttatc cttttacact gccgcttgca atcccgcgga caaaatattt ctgcatcaat 3168481 aaaaatagaa taataatcgg cgcggctgaa atcgttaacc ccgccagcag gacgccccag 3168541 tctgtctgca gcgcgtctct gaactgcatc agcccggctg gaatggtccg taaattctca 3168601 tcatctatga aaataatcgc aaacataaac tcattccatg tatggtaagc cgtcaaaatg 3168661 ccggatgtca ccaaaatcgg cacgctcatt ggtaagaaaa ttctgaaaaa tactccaaaa 3168721 cttgtacacc catccaaata ggccgcctcc tccaattctt ttgaaataga aagaaaataa 3168781 gagcggatca aaatgatggt gaatgggatc cgataagccg catacggcaa gattaacgcc 3168841 caatacgtat tgtacaggcc cagcgactga ataatagaat aaagcggcac aagactgacc 3168901 tgcggcgtca gcatcaatcc gccaagacat agcaccaaaa agaatccttt tcctttaaac 3168961 tcaaaccggg aaaggccata cgctgcccat gcactgataa agacagtgat cacacacgtc 3169021 agcgccgtaa cgatgacact gttcataaaa taagaagaaa tcccctgatt ccaggcggaa 3169081 acaaaatttt ccggatgcca cgaagacggc agcgaccagc tgtgctcaaa aatatcgtca 3169141 gagtttttaa aggcgctcat caccatccag agaagcggat aggcaatcgc aatcagataa 3169201 agaaacagaa aaacccacac agacgtttct ccgatatacc attttcgtct aggcttatct 3169261 ttcacctcaa tgtgctggtc aggcaccggc tccaatctga acgaatctgt cttcttctga 3169321 ggcagcatca gttactcctc ctttccggtt ttaaagaact tcatttgcat gagcgataat 3169381 gcaagcgtaa tgattaacac gacagtggca atcgctgagg cgtagcccat catatccttt 3169441 gtaaaggcgc ttttatataa aaacgtgctc aagacttctg acgcttttcc cggcccgccg 3169501 cctgtcaaaa tgtacggctc attaaagacc gtaaaggctc cggtcagcgt catgaccacc 3169561 gcaacaaaag acatctcttt cgtctgggga acagtaatat gaaaaaactg ctgaatttta 3169621 cccgcgccgt caagccgggc cgcttcatac agttcatccg gtattttttg aatcgacacg 3169681 atgtacagca tcgcaatata accgacagat tgccactggg acacaaaaat gacagaaagc 3169741 atagctgtgc tgtcatcccc gagccaggcc ctcgtcagct gatcaagacc gatggcctga 3169801 agcagctgat tcaaaagccc tgtctccgga ttgtaaataa aatcaaacaa aagcgcgatc 3169861 accgtcattg agatgacaac cggcaaaaag aaaacggtac gaaaaaacgg cgaccatttt 3169921 ctgaccagct tatcctcaag caccgccgcc aaaatcaaac cgccaaatac ctggcataca 3169981 attgagatca ctgcataaag cacattattg gtaagtgcct gatagaagac aggatcatga 3170041 aataattcaa catagttttt taagccgata aacgtttttt ccggagaaaa tgagctccac 3170101 tgaaacaggc tgaggaatac attctcaaaa atcgggatat aaacgaaaag taaaaaaacg 3170161 agagcgggca ccaaaaacaa ataggggatt attttattct gattgaccaa gggtatctca 3170221 tctcctttat aaaaagaaaa ggtgcgaagc ttcacctttt ctttgattta ttcagctgac 3170281 gccctcacct gctttgctgc cttttgaacg gctttcatca cctgctgcgg tgtcatgtcg 3170341 ccgccaagca tttgctggac gcccgttagg tacgcatctg cgacttcaac atcgacatcc 3170401 atatcaaacc atggaaccat tgatttggca tcaacaatat gctgaacggc ttcacgctga 3170461 atggctgttg cattttcttc agtagccgta ccttgcactg cactgtattt cccgacatct 3170521 ttcacgagct tttcgcccat tcttttcgac gtcaagaact gcaaaaattc catcgcttcc 3170581 ttcggatgtt ttgttcttga ggagatcatg aatccttccg gcgctcccgt taacgcttct 3170641 gaagatcctt tctgcccgct gatttcagga aatgggaaca tcccgagatt aaccggttca 3170701 accagcttga tttccgctgt ttccgcatat atcatcgccg actttccgct cttaaattgc 3170761 tgtctcacat attcgtggtc gacggagttt acatgtttat taaagtaagg catcagctct 3170821 tgaagctttt caagtgcttt tacgtagcct tcatcagtaa attcacccgt tttggcgtta 3170881 tagtcctttt cccgtgtttt ttcatcgacc atccgctgat taagcgtgcc gatatagtgc 3170941 gagattgtcc aagtcgcctt tgttccaaag ctgatcggtg tgtagccatg ttctttcagc 3171001 ttttttgaca catcgattaa ttcatcccac gtcttcgggg gatcaagatt cagcttttgg 3171061 aaaatgtctt tattatagaa gaatgattta gcgtccattt gccacggtac gccatattgc 3171121 ttgttttcat aagtaaatgg tgtaatttgc gattgaacga gctgtgatga ccaatcggtg 3171181 tcatttttgt agtaggacga gagatcaagt gctttattgc ctctgataaa tttaaaagca 3171241 aactcatcgc tccaagagaa gtaaatgtca ggagggctgg tggttcccag catgacctta 3171301 attttatctt tataggagtc atttaaaacg gcttcaattt gaatgtcgat atctgggtga 3171361 tctttttcaa attccttaac aacctcttca aaataacttt tttccggctc ctttggccat 3171421 ctgtggaaaa atttcaatgt cacctttccg tccgctgaac tgctttggct cgaacagcct 3171481 gcgatggtga gcatactgac agctgcaatg atcaagaaca acaacatttt cttcaaaggg 3171541 ttggcctcct ctggacatta gactataatg ttatataaca ttatagtcta atgcataatg 3171601 gttcttcatt ttcagatcaa tactcaactt tccacatgta tcttctatga gataaaggat 3171661 gatttctctc ctctgccagc tcgtctgcat agcttctcag cacacgattg agaacgagcg 3171721 gagcaagata gcctttaact gaatcgtcaa ttgcagtgaa gtcgtaagat gcagcatcaa 3171781 gcacagtgag ctttttgcca tactttttcg agaaggtaag cgcccgctct tcaagaggtc 3171841 ttgtttcatc taaaccgagc aggatgataa acggcacgga ttcatcaata atttcaaacg 3171901 gtccgtgaaa atattctccg gcatgaatgg cgtgggaatg aatccattgc atttccatga 3171961 gaatgcagat gctgtaggag taagcgacac cgtagtttgc accgcttgcc atggtataaa 3172021 taatgctttc tttttcatgg gcttttgcaa attgcttggc gttgtcagct tcctgcttaa 3172081 gggctttttc atatacagcc tgcaattgat ctaagccttc aattgcttgc tcaaatttcg 3172141 tattgttttc taatacttgc agggttccaa aaacgatttg atacaaaacg ccatagtttg 3172201 tattgatcgc aagcgcctca tcaccccaat cgtactgggc aacatattgc gcttcctgcg 3172261 ctaaaggaga ctccggttta aacgtcatcg caatcgtaag tgcgcccttg ccccttgcaa 3172321 acgcagcagc tttgactgtc tccggggtat ttcccgaatg cgagcacaaa ataacaagag 3172381 acttttcacc aagctgaaca gggttgcgct gaataaattc gttggcgctg tagagatcgg 3172441 agtttattga ttttgactct ctgtcaaaca catacttact cggatacata atggcagaag 3172501 accctccgca tgcgacaaag aatacatgat caatggtttt ccctttcaaa tcctgcaaga 3172561 aagcttgaac ctcacgattt acttttgctg tggcctgact caaatccttc actcctcgtt 3172621 tttattatat aacgttatat aacattatat attgttatat taaagtccgc gggtaggatt 3172681 gtcaatatta ttttctgaaa tttctcaata atttattcgg atgacagaca aagggtctat 3172741 atgcgaaaaa atgcccaaat caaaagccag aacttgactt aagctctggc ttcgctgttc 3172801 aatccgcaga ctgacgtctt atttaaaaaa taccttgtct atattgtact tcgagtgctg 3172861 tgtattgatg atatatgttt cgtaaatctc tctttccatt ggatcatcaa ctacacatac 3172921 ctcaatttta taaacttcat ctctgtgatg tttgatcggt gaaacagtgt cttcgaaatg 3172981 cttcttaatt ctctgtctta actttctggc tttaccgaca aacagcagct cgtcatgaat 3173041 gttgtaaaac ataaaaatgc cgcctttgtc ccttgggatc tggtgaaagt cgatgaatcc 3173101 gtgaatcggt tttatcttcg gctcgttatc attagctgac tgctgtcgtt cagtgatggt 3173161 gacattcggt gcgggtatat caatttttat caaaatcagt tcacgtcctc tttttcatta 3173221 aagataaatg ctaacacata cagaaaagaa aagctagaac agctttatta tatttgtttg 3173281 tcatgctctt acttattatg caagtgctcc ggctggatca taaggactaa ggtctaattc 3173341 tgtctgcttt ccgagaacta gctttgcgag ctctgcaccc aaaaacggcc ccatcgtcag 3173401 tccagaagca cccaaaccgt ttgcagcgta caggccttga acattcggca cggcccctac 3173461 gaccggcaga aatcccggtg taaacggcct gaagcccact cttgtttcaa cagcagccgc 3173521 atcagcaaga cccggtgcaa cggctaacgc tttgctcaat acttcgtgct ggcctccggc 3173581 tgtcacacga agatcatcaa gaccggcatc gttttcgtgt gtggcgccgg ctacaattct 3173641 gccgttatca aacgacagaa tgtactgatc actcggcggc attacaaccg gccacgatcc 3173701 tgtatctgca tctgtcattt caaaatgcat aatctgcgct ttttgaaatg acacttgaaa 3173761 atgaatgcca agaggcttca atatctcatt ggcccatgct cccgccgtca caatgaccgc 3173821 gtcagccgca aactgctttg tatctgtttg cacgccggtg actgttccgt tttcaaaaag 3173881 caaggacgca tttcctttga tgaccgttgc gccgcgtttc tctgcagcgc ttaaaagcga 3173941 ccggcacagc gctcttccgt tcacacgggc ggcaccgctg atatgaaccg attcatagcc 3174001 gtcagctaaa atcggaaaca gctttttcgt ttcacttgca gacaagcggg taatgtcgcc 3174061 gatttccggc gcatcctccc gtctcttata cgccctttcc tccattttat cgagtttaga 3174121 cgcgtcagta tgaatgctga tggcaccgac acgtttgtat cctgtatccg attcaccgtc 3174181 tttttccaat tgatggatta aatccttata gtaccgcgct ccccccttag caagctggta 3174241 ccaatcctga ttacggcgct gcgagagcca aggacagacg atccccgccg ccgcatcagt 3174301 cgcttgtccc ggctctttcc gatcaatgac agtaacgcga gcgcctgttt ttgcgagatg 3174361 ataagccgtc gacgcgccca gaatccctgc gccgacgatg atgtacgatt tcatatgcaa 3174421 acaccttttc tattataatg tctattcatt ttaccaaatc aaatgctttc cttcgacctt 3174481 ttgccctaat gtggaaaaac cgcgaagttc gtccaatctc tttactctcc tatcgaatat 3174541 cctgtcacta tcaatagaga aaggatgata ccatgagcga aaatcgtcat gaaaatgaag 3174601 aaaacagacg cgatgcggca gtggcaaaag tccaaaacag cggtaatgca aaagtcgtgg 3174661 tcagcgtgaa cacagatcag gatcaggcac aggcgcagtc acaagacgga gaagactaat 3174721 gaacgaaaac atcattcctc ttaacagaca tactcaagag atacccacta ctgaatctgt 3174781 tatcaaaaac agcggcaact cagaggtcca tatcgacatt cacattgata caatgccaat 3174841 tgcttttgct atattatgct ctgcattagc cgcaaagcag atgacaaaag aggaattcga 3174901 tatggcttat actcaattgc gagagatgaa cagagaaaat aacagcagat catctgtaaa 3174961 gcaaattatc aatcaagaga cagaagaaga gtaaaaaacc gcggcccctc ggccagcggt 3175021 ttttcttctg catacaaaaa ggacgcgact gaatcggtta cttctgtaca atttgaataa 3175081 ggttaccgca tgtatcgtcg aagacagcta ttgtgacttc gcccattttt gtcggttccg 3175141 tcgtaaacgt cacgcctttt tcctttaatc ggttgtactc tttttgaata tctgcaacgc 3175201 caaacattgt ggccgggagg ccttcggaga atatcttctt ttgatactcc ttggcggcag 3175261 gatgttcatt cggttcgagt aaaagctcgg ttccgtcttg atcatctgga gaaacaagcg 3175321 ttatccacct gaatttcccc atgggaacgt cttccttttt tataaaccca agtttttctg 3175381 tataaaactc cagtgccatg tcttgatctt gtacaaatat actggtaaca acgattttca 3175441 tactgttttt ccctccttcg atatgaatga agcatggtac tatgctaaca atctggctac 3175501 aagcaaaaca acccacacat ttatcagagg ccctgttctg attttataaa attattctat 3175561 ccatcctttc agcaaatttt taagcggttc gttgttgaat ataagtactc gatattttcc 3175621 ctttcgtttt gatgttacga gtcctgcatc ctccagtaca gaaaggtgtt tagctatcgc 3175681 ctgtcgcgta atagaaaggt cgtactttgt aataagacgt atcgtaagtt catacaacgt 3175741 cagctcgttg cgttcagata attcgtctaa tataagccgc cgagtcgaat cgccgagtgc 3175801 tttgaatata gcgtctttgt tcccattcat atattgagta taagcaaccc attagttgca 3175861 tgtcaagtat aagcaactgt atggttgcgt gatatagaaa ctgaacctat ccggcgcagg 3175921 tctgaaatat tctaatcgat aaggaattaa aaccattaaa ataacagtgg atatgtctct 3175981 gaaaaataaa agaagacgaa cttcaaaagt tcgtcttcta caatcaaatt cggcacgccg 3176041 gccattttaa agttgataac tatctctaaa ccccttgata aacaaaggag ttttcatcat 3176101 taaccgatag aaccttccat ttcgaactta atcaaacggt tcatttcaac tgcgtattcc 3176161 atcggaagct cttttgtgaa tggctcgata aagcccatta cgatcatttc agttgcttct 3176221 tcttcagaaa taccgcggct catcaagtag aagagctgct cttcagatac tttagacact 3176281 ttcgcttcgt gctccaatga aatgttatca tttaagattt cattgtaagg aattgtgtca 3176341 gaagttgatt tgttatccat aatgagcgta tcacactcga tgttagagcg ggcgccttcc 3176401 gctttgcgtc cgaagtggac gattccgcgg tacgttactt ttccgccctg ttttgaaatc 3176461 gattttgata cgattgtaga tgatgtgttt ggtgcaaggt gaatcatttt cgcacctgca 3176521 tcctgatgct ggcctttacc cgcaagagcg atagaaagcg tcataccgcg cgcgccttcg 3176581 ccttttagga tacaagccgg atatttcatt gtcagcttag aaccgatgtt gccgtcgatc 3176641 cattccattg ttgcgttttc ttcacagact gtacgctttg ttacaaggtt gtaaacgttg 3176701 ttcgcccagt tttggatcgt tgtataacgg cagtagccgc cttttttcac gatgatctca 3176761 acgaccgcac tgtgaagtga gtttgttgtg taaacaggcg cagtacagcc ttcaacataa 3176821 tgaacgcttg cttcttcgtc aacaatgatc agtgtacgtt cgaactgacc catgttctca 3176881 gagttgatac ggaagtaagc ttgtagcggt gtttcaacct tcacgccttt aggcacgtag 3176941 atgaaagaac cgccggacca aacagctgag ttaagcgccg caaacttgtt atcagtcggc 3177001 gggattactt ttgcccagtg ctcacggaaa atatcttcat tctctttcag cgcgctgtca 3177061 gtgtctttaa agacgatgcc ttgtgcttca agatcttctt tcatgttgtg gtatacaacc 3177121 tcagattcgt actgagcaga aacacccgca aggtattttt gttcagcttc aggaataccg 3177181 agcttgtcga atgtttgttt aatttcttca ggaacttcat cccaagaacg ctctgaacgc 3177241 tcagacggtt ttacgtagta cgtaatttcg tcaaagttca gtgagtttaa atctccgccc 3177301 cattgaggca tcggcatatt gtagaaatgc tcaagtgatt tcaagcggaa gtcaagcatc 3177361 cattgaggct cttctttcat gcgagaaatt tcttctacga tttcttttgt caatccgcgc 3177421 tctgaacgga aaatggaaac gtccttgtcg tgaaaaccat acttgtattc accaatatca 3177481 ggcatttttt tagccatcca ttttcactcc aatcctttta attgccgcct tcttctttcg 3177541 cgactccttt ttcaagtgct ttccatgaca gggttgcaca tttgatacgg gcagggaatt 3177601 ttgaaacgcc ttgaagggct tcaatatccc cgagatctat agaatcatca tactctttcc 3177661 cttgcatcat atccgagaaa atcttagaca tggaaagggc agtttcaata tctttccctt 3177721 taatcgcctg agtcatcatc gaagcggatg ccattgaaat ggaacagcct tccccttcaa 3177781 acttcgcatc ttccacgatg tctccgtcaa gcttcattgt cagtctgatg cggtcgccgc 3177841 atgtcggatt gttcatatcc acgacaatgc tgtcatttaa aaccccttta tttcgcgggt 3177901 ttttgtaatg atccataatc acctgtctgt acaatgtatc taagtttgca ttaaaagaca 3177961 tttgtaaaat actcctttgt cttttgaaga gcttccacaa gcttatcaat ctcttcctct 3178021 gtattataca gataaaagct tgctcttgca gtagcagtta catccagcca tttcatcagc 3178081 ggctgcgcac aatggtggcc ggctctgact gcgattccct ccgcatcaag cacagtcgcc 3178141 acatcgtgcg gatgaacatc atcaaggtta aatgtgacaa gcccggcacg ctcttccggc 3178201 ccgtaaaccg ttacgccgtc aagctggcgg aagcgttcaa gcgcataagc tgcaagcttg 3178261 tgctcatggc gggaaatctc atcaagaccg atttcttcga gaaaatcaat ggcggcaccg 3178321 aggccgattg ctcctgcaat aatcggcgta cccgcttcga atttccacgg aagctctttc 3178381 caagttgatt cataaagccc gacaaagtcg atcatttcac cgccgaattc ggcaggctcc 3178441 atgttttcca gcagggcttt ctttccgtac agcacaccaa caccggtagg tccgcacatt 3178501 ttatgggaag aaagcgcaaa gaagtcgcaa tcgagatcct gcacgtcaat tttcatgtga 3178561 ggcgtgcttt gtgcaccgtc caccacaatg acagccccat tgtcatgagc gattttcgcc 3178621 atttctttaa tcgggttgac cgtgccgaga acattagata catgagacac cgcaacaatt 3178681 tttgtgttgc ttgtgaccgt ttctctgacg tcttctaaag aaatcgttcc gtcttcctgc 3178741 aacggaatat attttaatgt ggcgccagtt gcttttacag cctgctgcca cggaatgata 3178801 ttcgcatgat gctccatgta ggtgatgacc acttcatcac caggtttcag gttggcgcgc 3178861 gcatagctta acgccaccat attcagtgat gtggtcgtgc cttttgtgaa aataatctca 3178921 gccattgact tcgcgttaat aaacttgcgg actttttcac gcgctccttc ataaccatct 3178981 gtcgctctgg ttccaagtgt atggacgccc cggtgaacat tggaattgta ttggttataa 3179041 tacttatcca gtgtttcaat gacagcacgc ggcttctggg aagtcgccgc gctgtcgaga 3179101 taaacgagat catgtccgtt cacttgctga tgaaggatcg ggaactgttc acgaatatct 3179161 gtgatattca ttacttcact ttcctttcga taacagaaac taattgtttc ttaacgcctt 3179221 caatcggaag ttcatttact accggtgcaa ggaatccgta aatgactaag cgttctgctt 3179281 cttctttcgg aattccgcgg ctcatcaggt agtaaagctg aatagggtcc acacggccga 3179341 cagatgccgc atgtcctgca gttacatcgt cttcgtcaat taaaagaata gggtttgcgt 3179401 ctccgcgtgc tttttcgcta agcatcagca cgcgtgattc ttgctccgca ttcgctttag 3179461 aagcgccatg ttcgattttg ccgattccgt taaagataga agaagcggaa tccttcatca 3179521 caccgtgctt caagatatag ccttcagaag ctttaccgaa atggatgatt tgtgttgtga 3179581 agttttctgt ttgctctcct cttccgacaa caaccgtttt cgtatcgccg tatgtgccgt 3179641 caccgtaaag gtttgttgtg ttttcggaaa tcgtgtcgcc atcgttcatc aggccgagag 3179701 cccactcgat tttgctgtcg cgtccgcgcg cagcaccgcg gcggttcaca taagttgtca 3179761 caccgcttga cagattatcc accgcaccgt atgtcacgct ggcattatca cctgtgatga 3179821 cctcactgat aatattgaag acagcgtctt tcgggtttac agtgctgatg tagttttcta 3179881 catatgttac agagctgtgg tcttcagcca caatcagcac gtggttgaat agagctgtat 3179941 cattgctttc gtggacataa acagcctgaa ccggcgtctc cacctgaaca tttttcggaa 3180001 cataaaggaa tgctcctccg ttaacaagag ccgcgtgaag tgcagttaac ttatgttcgt 3180061 caaccttcac gccgtccttc ataaagtatt tctccaccaa gtcgctgtgc tcgcgtgcag 3180121 cagtcagaat atcagtgaag atgacgcctt tgtctttcaa ttcttgagaa agagaaagat 3180181 gtgccggcgt ctggtcacgc tgtacgtata atgttttatc ttcgttttca atgtcgatca 3180241 gcgcttttac ttcatcagtc aaatcttcta atgaagaaag cggttcgtta tccactgtat 3180301 gcttcgcgaa attcgtgaag ttccagtttg tgatttttgt tttgtcaggt ttcggcatcg 3180361 gcagatcctc agcttgttca agagcctgta agcgcaggtt cttcagccag gcaggttctt 3180421 ggtgcttttc ggaaaagctt ttgagatact cctgatctac ggatagtttt gtacctagtg 3180481 tcatattaat ccccctaacg cttacgcttc ttggccaaca gtttcgtctt caatgccaag 3180541 ttcttgtttg atccagtcat aaccttctgc ttcaagacgc tgtgcaagct ctgcaccgcc 3180601 ggattttaca acgcggcctt gcatcataac gtgaacaaca tccggagtga tgtagtttaa 3180661 caggcgctga tagtgagtga tcatcaggca gccgaagttt tcgctgcgca ttttgttgat 3180721 cccttttgat acaactttca aagcgtcaat atcaaggcct gagtcaattt catcaaggat 3180781 ggcgattttc ggttcaatca tcattaattg aaggatttcg ttgcgttttt tctccccgcc 3180841 tgagaagcct tcgttaagat agcgctgagc catttcaggg tccatttcaa ggaactccat 3180901 gttttcgtcc attttgcgga tgaatttcat gagagaaatt tcatcgcctt cttctctgcg 3180961 cgcgttgatt gctgagcgaa ggaagtcggc atttgtcaca ccgctgattt cacttgggta 3181021 ctgcattgca aggaataagc ctgcctgcgc acgctcgtcc acttccatct ccagtacatc 3181081 tttgccgtca agcgtgatgc tgccttttgt tacttcatat ttaggatgcc ccataatagc 3181141 agctgataaa gtggatttac cagttccgtt cgggcccatt actgcgtgga attctccacc 3181201 ttttatttca aggtttacac cctttaagat ctctttccct tcgatttcaa cgtgaagatc 3181261 tttgatcgtt aatgttgaag cagccatatc tatacctcca aaaatatata atcattattc 3181321 tcattttatt ctcattctaa ttttataaca aatgaaaagt aaatacaact ttttatcgtg 3181381 ccttgcacat tcctcaagtt taacaaagat cagcacttta ttaaagcgat tgaaaaagaa 3181441 aaagagtgga ttcccaccct tttttaaaag attgattttc tcaataagct cccgcagaaa 3181501 tccgcttgct tttttcataa tcaagctctc tctgccgctc tactttcatt cttgtttcca 3181561 gccggcgtcc atattcctcg tatccaattc cgtgtgacag ctgcatcgct ttttccattt 3181621 ctgacgtata atcgaggttc agtctgtcct ggctgctgca aataatgaat caatcccttc 3181681 atatatttgc tttttattgt accagtgctg cgttggatgc cgcaaaaacg atttggcgtg 3181741 aaatagcggc agatgagacg aaagcatcct ttcagaacaa atgagaatgg tttttcggaa 3181801 tattccttct cttaatgcgt ggtgtttccg aattcctcaa tgcactgttg aacgactgtc 3181861 acgccttggc tgaaagctgc gccgcctcca aatgccgctg ccacactgac ggcttcgaga 3181921 atgttttctt ctgacgctcc ctgatcaaga cagccttttg tatgatagat catgcaatat 3181981 tcgtcctgag cattgatggc aattccgagg gcgatcagct gtttttctct ttcagtcaga 3182041 gaattcccgg caaagcactg ttcagtaaat tcgttaaatt ttcttcccat cagcggcatc 3182101 ttttgttcaa atgtgcctaa accatgttta tattgtttta acgcgtcctg catgcttcct 3182161 ctgtcttgat tcaaagaaaa tccctccatc tgtttaacat tcctttttat tatgaacagc 3182221 ttttaggaaa atacgcgaaa aaaaccccgg aattctcatc cggggtttca gtcttattca 3182281 gatacaggaa gcacagctcc gtcgtatttt ttctcgatga agtctttgat ctttttagag 3182341 tgaagaactt ccatcagcgc tttgattttt gcagaatctt cttcgccttt tcttactgcg 3182401 atgatgttag cgtatgggtt gtttttcgtt gattctactt caattgcgtc ttttttagga 3182461 tttaatttat tttggatcgc atagtttaca ttgatgaaga ccgcgtctcc ttctttgttt 3182521 tcatatgctt ttgccgttaa ttcaggcgct acttttttga attcaaggtt tttcgggttt 3182581 ttcttaatgt ctttcaatgt tgcgtcaact gtttccactt tagaatcaag agtgattaat 3182641 ccagcgtttt caagcattgc aagcatacgg ccttgttcag caacgttgtt tgtcagaatg 3182701 attgtcgcac cgtctggaag gtctttcagt gatttgtatg ttttagagta aataccgaat 3182761 ggctctaagt gaacagcgcc ggcattcaca agtttgtaat ctgtgttttc tttcatttct 3182821 tgctcaaggt aaggaatgtg ctggaagtag ttcgcgtcca cttctttatc agctaaagct 3182881 ttattgtaca ttttgtaatc actaagcact ttcactttca gcgtatagcc tttttctttc 3182941 agcaatggtt cagcttcttt taaaatttcc gcatgcggtg tttttgttgc cgcaacgaca 3183001 atttctttct tgccggattc agcgccgtta ttcgaaccgc aggcagccat aactcctgca 3183061 aatacaagca gtaatgcacc caaaaatagc tttttcaatg taaatcctcc cttatcgttt 3183121 gtctataata tttgttatta gatcaccgat gatttgaata ataaacacga tgattaaaat 3183181 aaacacagta gcaacgaagg taacatcagc gttattagac tgatatcctt ctacgtacgc 3183241 aaggtttcca aggcctcctg aaccaatggc tccggcaatt gccgttgaac cgattaaagc 3183301 gatggctgta accgtaatgc cagaaataag agcaggcatt gattccggaa tcagcacttt 3183361 gaaaataatc gtagacgttt tcgcgcccat tgatttagct gcttcaatca cacctttatc 3183421 cacctcacgc agcgcgattt caacaaggcg cgcgtaaaat ggtgccgagc cgattaccag 3183481 cgccggcaat gcggcgtttg gccctaagat cgtgccgact aaaaatttcg taaaacctaa 3183541 tagtaaaata attaaaataa ggaacggaat cgatctgaat atgttaacaa cggctgcaat 3183601 cactgagttg accgctttat tctgccagag gcttcctttg ctcgtcagaa agagcagcaa 3183661 gccgaggatg accccgatga caaaagcaaa cagtaaagaa atcagcgtca tataaagtgt 3183721 ttcatatgtc gcgttccata attcagttaa atcaacgttc gggaagtatt tttcaaacat 3183781 tcgtgatcac ctctgctttc acctgtttgt cattaatgaa tcggatcacg ttttgcactt 3183841 cttcctcgtc cccgtcaatg tggatgaaca gtgaaccgta agccccatcc ttcgtctgcg 3183901 aaattttccc ttgcagaata ttgacgctga cattgaagtt tctgatcatc tctgtaatca 3183961 gaggctgttc agctgactca ccgacaaatg tgagctgaac catttttcct gatgctgtat 3184021 catcaagaag gtgctgaagc gtctctttcg tttcttccgg ctctgtcacc tgttgaacaa 3184081 atcgttttgt catttgttcc tttggatttt tgaagacatc gagaacctcg ccttcttcga 3184141 ccaccttgcc gttttccatg acggcgactc tgttgcagat tttgcgtatg acatgcattt 3184201 cgtgcgtaat cagcacaatc gtcaaaccga gtctttcatt aatatcggac aatagatcca 3184261 gaattgaatc tgtcgtttgc ggatctaatg ctgatgtcgc ttcgtcacaa agaagaacct 3184321 tcggattgtt tgcaagcgct ctggcaattc cgacacgctg cttctgaccg ccgctcagct 3184381 gggacggata agatttttct tttccttcta aacctaccag tttaatcagt tcattggcgc 3184441 gcttgatccg ctcgctcttt ttcaccccgg caatttctaa aggaaacatg atattatctc 3184501 tgacagtccg cgaccaaagc aaattgaaat gctggaaaat catactgatc tcatggcgtg 3184561 cttttcttaa accgcgtcca tttacttcat taatcttggt tcccgccact tccacggttc 3184621 ctgaggttgg tttctcaagg ccgttcagca gacggattaa ggaactctta ccagctccgc 3184681 tatatcctat aattccaaaa atctcacctt ttttaatgga aagcgagacg ttttggacag 3184741 cattgacatc tccatgtttc gacttgtaaa cttttgaaac atcctgaaga ttgatcaaag 3184801 caatcacctg ccttaacact attctaagaa atcttccggt tttttctgca aaagaaaagc 3184861 ctttctgcac acttgagcag aaaggcttat ataaaatgcc tttctctcat ctttcaaagc 3184921 tgaacgcttc gtgtgaattg gcaccatttc aacagtgttg atggttgccg ggcttcatag 3184981 ggcacttccc tccacctctc ttgataagag aaatatatag tctttttcgt ccggaaattc 3185041 ttaatgtaga atagcacggc gaatgattaa atgtcaataa aataaatgat gtcaactttt 3185101 actattataa taatttatta ttttttaatt ttttaaaatc ctctgaaaaa atccatttgt 3185161 cagccagaga atggcttcca gctttaacag ggccctgaat gaccccttta ctttgaggct 3185221 tccgctctga ataaggtgct gaagggaaat gtctccgtgc aataaatcaa taatttccgt 3185281 ttggtttccg taaaaggtca ggttggacgt ttggggcgga gaaacttttt tcatttctcc 3185341 ctgttcgttt attgagacgg ttaaggcttc tgcttctcct tggaaggtaa tgagcaatgt 3185401 tgaggcattc aaaaggggtt ttaaaaacag atgctgatac tcatcttcta aaacttccgc 3185461 tttctccata tgtacaacct cctatttgtt ggtcatacat acacatttct ctctttgtcg 3185521 caagaacccc tttataaaac gaacgacaat ttcattggat atgctgagaa atatgtcata 3185581 aatgggatgc ggaagatgat ttttgtttga tcagctcata taaataagaa acggaatgaa 3185641 atgcatatcc tctttcgacc atctttccgc ctttaaacag cagaaaacaa gggacgcttt 3185701 caatttgata cgcttttgcg aatgtcggag agtaattgac attgttttga tagaaggcga 3185761 catccggcag catttctttc accactgtca gcattttgct tgcaagctgg caggtgccgc 3185821 aaaacggagt atataaatat agaaggtaca catcatcttc aatgtgatca agttcgtgtt 3185881 cttggagttc tttcatgcta tacacctcgg gactttcttt caagaaaaat agtatggaca 3185941 ttcagattcg cacgcagcaa tacagaagcg atatggtgcc tgggcgcagc cgctacttcc 3186001 ttataggctc tgtcgacatg gagatggcag gcttcattaa attcacgctt cagctgtttt 3186061 ctcaatttct cacctgattc atcagcatca actaatatat agacgtcttt atcataaagc 3186121 tcgtcagcca attcctcgag cctcagctgg ctgattgttc cgtttgtgca gataatgcgc 3186181 atcggttcat tcaggacgct ttcgattttc tctttatctg atttcccctc gacaatcata 3186241 accttttcca gctcatccat cttcatcttg ttcacctgcc gcgtcaaatt tgaaatgttc 3186301 agattgtaaa agaaggcagt gaaattcacc gccaacatta acaccagccg ttttcgtagt 3186361 cacaatctac atattttgcg tcgtctccag agaccacatc ggctgtctta taaaatttct 3186421 cattttcaaa ggaataaccg gacttaagct catattcatt catgcttgtc atttggccga 3186481 tcatctcatt atcatgatat aacgagagcc ggccattttg aaagcggcct gtcacgtcat 3186541 tggtgacatc gagcttttgt ttgtcgaaag ccatattgga cacctcccat aacgttagcg 3186601 tgtccaattg cttttacggc tatcctgttt tagtcttctt gtgtcatctc ttcgtattgc 3186661 tctgctgtca tcagtttttc aatttcagaa gcgtcagatg gctcaacgac gatcatccat 3186721 gctttttcgt acggagattc gttgacgaat tccggactgt catcaagatc ttcgtttact 3186781 tccacaaccg ttccgttaat cggtgcataa agctcagata ccgttttaac ggattcaaca 3186841 ctgccgaatg gctcgtccgc tttgatttca gcgcccactt caggaagttc gacaaacacg 3186901 atgtcgccta gttcggactg ggcaaaatgc gtaattccga ttctggcttt ttctccttca 3186961 acttttaccc actcgtgttc tcctgagtaa cgcaaatctt ttggtatgct caattgaatc 3187021 cctccatttt ttacagcact acaataagaa gataccacac ttttcaaaaa aaatttacat 3187081 taagcccagt tttcttcaaa ttggtcttct ttaaatccga cagtcacttt ttcgccgtct 3187141 gttgtaagcg ggcgtttaat tagcatacca tctgaagcca gcagttcgag ctgttcgtcc 3187201 tctgacatat gatacagctt ttccttgaga ttgagctcgc ggtatttcat gccgctcgtg 3187261 ttgaaaaatt tcttgagatc cagcccgctt ttttcataaa gcgcttttaa ttcttctttg 3187321 cttggcggct gctcagcaat atgtatttcg tttatttctt tcccatgctc ttcaagccac 3187381 ttctttgctt tgcggcacgt tccgcattta gggtaccagt aaaaagttaa cgacatcttc 3187441 ttccccctca ataaaataat cgaggttatt ttaacacagt ttgttttaaa aacctaaaac 3187501 agtgcttctt aaaaaagagc tccgcgcatg cggagctcat ggccaatcag acagtatatt 3187561 tctcagcctc aaaaatgcct gccgccgcct cgcgtttttt ctgaatcacg tttttaggcg 3187621 ttacgcgtgt cagcttgcgc agagcggaaa gcatcatgcg gagtgaatct ccttcttcca 3187681 ttgcgataag ggattccttt gcatgcgctt cgatttcgtt aaaggcctct tgaacgaaaa 3187741 tttctgtgta cagcaccttt tgcgctgctt tttcagcgcc ttgtgcggca atggcctttt 3187801 ccgttctgag cacggctgat tccattgcgt atacattgct gacgatatcc gctacgttca 3187861 cgagaatttc ttgctcacga tcgatcgctt ttccgtattt ttgcgcggct aggccggcag 3187921 caaacaacgc aatttttttg gcttgcttga cgatatattt ctcctgctct aagacgccgc 3187981 ttccaggctc ttcaggcata agcatcatga gttcttcctg cagcgactgc gctttttcga 3188041 ataaaggcag ctcgccttta agcgcttttt tcaggaaggt gcttggcacg attaaccggt 3188101 tgatttcgtt tgtgccttca aaaatccgat tgatccttga atccctatag gccctttcta 3188161 cttcgtattc ctgcataaag ccgtagcctc catgaatctg cacgccttca tcaacgatat 3188221 aatcaagcgt ttcagagccg aataccttat tcagagagca ttcgatggcg tattccgcaa 3188281 tcgatttggc gatttgccgg ccgtccttga gatcttcggc cgtgaactgg ctcatattgt 3188341 cttcaaacag cccgacggtt ctgtatacag agctttccat cgcatacagc cttgaggcca 3188401 ttgtcccgat tttttcctgt gtcaatgaaa aaccagcaat cggcgtttta aattggcggc 3188461 gctgatttgc gtatgccgca gacagctcga tgacgcgttt agatgcgccg attgtgccaa 3188521 ccgccagttt gtaacggccg atgtttaaaa tattaaaggc gatgacatgc cctttgccga 3188581 tttctccgag caggttttcc tttggcactt cagcttgatc cagaatgagg gttcttgtcg 3188641 atgatccctt gattcccatt ttcttttctt ccggtcccgt ggagacaccc gggaactctt 3188701 tttctacaat aaaggctgaa aacttgtcgc cgtctacctt agcgtaaact acaaatacat 3188761 cggcaaaagc agagttggta atccactgtt tttcccctgt taatacataa tgggttcctg 3188821 cttcattcag cacagctgtt gtttttgctc caagtgcatc agacccagag ccaggctcag 3188881 tcagagcata agcggcgatc ttttcgcctg aagcgagtcc aggcaaatat tttttctttt 3188941 gttcttctga cccgaaaaag acgatcggca aggaaccgat accgacatgc gcgccataag 3189001 aaagagaaaa gcttcccgca cgcgaaaatt tctcagtgat gagtgccgag ctgattttat 3189061 caaggccgag cccgccgtat tcttccggca catcggcgcc aagcagccct agttcgcccg 3189121 ctttcttcaa cagtctgaca gaatgctcga attgatggtt ttcgatatca tctatatgag 3189181 ggagaacatc ttgctcgatg taatcctctg ttgttttcgc aatcatttta tgctcgtcag 3189241 tgaaatcctc cggtgtatac atttgatcgt atgtgacatc ctcgattaaa aatccgccgc 3189301 ctttttgtac gtcagccgct ttttttgcca tttgtttttc cccctttagc ataattcaaa 3189361 tacaccggcc gctcccattc cgccgccgat acacatggtc acgactccaa attgctcgtt 3189421 tctccgtttc atttcatgga tgagtgagag tgtaagcttt gtgcccgtac agccaagcgg 3189481 gtgtccaagc gcgattgcgc ccccgttgac attcactttt tcttcatcaa ttcccaattc 3189541 cctgattact tgaatggcct gtgaggcaaa agcttcattc agttcaaaca agccgatgtc 3189601 ctgcagctga agtccggcaa gcttcaaagc gcgcggaatc gcttccaccg gtccgattcc 3189661 catcacttcc ggcggcacgc cgcctaccgc aaaggagcgg aatttcacaa gcggcgccag 3189721 gccaagagca tcggcttttt cccggtccat cagcatgaca gccgccgctc cgtcactcgt 3189781 ttgtgaggaa ttgcccgcag tcaccgtccc gtcaacggaa aaggccgggc gcaatgtcga 3189841 taagatgtct gcagtcgttt gcgggcgaac accttcatcc tgagaaaaca caaactgttt 3189901 ttccataggc ttatggtctt ctccgatttc tgtcaccgtc acttcgacgg gtacaatttc 3189961 atctttaaat tttccttctg caagggcttt agcggcgttt tgatggctgc gaacggcaaa 3190021 cgcgtcttga tcctcacggg agacgccgta ttttttcgcg acttgctcgg ctgtgtgccc 3190081 catgctcata taatattccg gtgccttttc tgccaaagca aggttcggac gggtaacatg 3190141 ccccatcatc ggaacttgcg acatggattc tgctccgccg gcgatcgctg tatcgtaggc 3190201 gcccagcata attttttctg ctgcatacgc aatagactga aggcctgaag agcaatagcg 3190261 gttaactgta atcgccggaa ccgtgtacgg caggcccgcg agcgcaccga tatttctcgc 3190321 catattaagc ccctgctccg cttcaggtgt tgcacagccg ataatcaagt catcaatatt 3190381 gccttcgtag ccgcctgccc gtttcagcgt ttcttttaca caaatcgctc ccaaatcatc 3190441 cgggcgaacg gtggccaacg atcctttttt tgcttttcca accggtgttc ttgcacctga 3190501 cacaatgact gcctctttca taagctccct cctaattccg taaaggttta cctttcacaa 3190561 gcatatgctg cattctcgct tgagattttg cctctcctga caaactcaaa aacgcttctc 3190621 tttcgatctc caataaatac tcttcatcaa cctctgtacc aaacggcact tttccgcccg 3190681 caatgacata agcgagtttt ttcgcgatct taaaatcatg ctcagatata tagccggaca 3190741 gcttcatctg ctcagcgcca agcaagagtg ccgcataacc ggtttctccc ggcaccttga 3190801 ccttttcttt tacaggcggc cgccagccgg tatcgtataa agatgcggcc agctgcttcg 3190861 catcgtataa caggtggtct tgattcacgc tgatctgatc cgtttctttt aagatgttca 3190921 tctcacgagc ctcttgagcg gaagcggaca ctttcgccat cgcgattgtt tcaaatgttt 3190981 tcattgccgc attcatcgga tcatggccgc ggcgaagatg gttgatgtac agctctttgt 3191041 tacctcctcc gccagggatg aggccgacac cggattccac aagtcccata taggcttcgc 3191101 ttgccgcttg aatgcgcgcc gccggcaggc atgcttccgt tcctccgccg agcgtcatgc 3191161 caaatggcgc ggcgacgacc ggtttcgcac tgtatttgat cttcatcatc gtctcctgaa 3191221 aacggcggat cacaaaatca acttccaaaa agttgtcatc ttggacttcc attaagatca 3191281 tggcgagatt cgcgccgacg cagaaatttt tcccttgatt gccgatgaca agccccttgt 3191341 aattccgttc tgtttcctct aatcctttgt ggatcatttg aatgatatcg aggccgatcg 3191401 cattgctttt cgaatgaaat tcaagaaggg ccacatcatc tccaaggtca attaagcttg 3191461 ctccgctgtt tttcgcaatc acgccttttg tttctttaag tgcttgtaaa tgaattcgtt 3191521 ttttgttttc tttcacggct ctgtattcgc cgcggtcata ataaaatacc gttccgttct 3191581 ctttgatgta gaaggtttca tttcctttgt ccagcatctc ttttatccag ccaggcatat 3191641 ctgctccaag ctgctcaagc ttttccgctg actgcttgag gccgatggcg tcccacatct 3191701 caaaaggtcc cagttcccag ccgaatcccc acttcatggc ttggtcaatc gcatgaatat 3191761 catcggcaat ctcgccaagc agctcggctg agtaaagcag ggtttgagaa gtgatattcc 3191821 acagcaaacg gccggccctg tcatccgaat aaataagcgc tttcattttg gcttttgtcc 3191881 cttttgcctg ttttgccgct tcaagtgccg gtgatttcat ttttgtccgc tcgccgtaag 3191941 taagcgtcac tgggtcaagc tcataaatcg tttttccttc ttttttataa aagccttggc 3192001 cggccttgct tccgatccac cctttttcca gcatatcgtt catgaagctt ggaatgcgaa 3192061 acacttcttt ttcatcgcca tcagctttgt catacacatt tcgggcaacg tgggcgaatg 3192121 tatcgaggcc gaccacatca agcgttctaa aggtggcgct tttcggcctg ccgatcagcg 3192181 gtcctgtgat cgaatcaacc tccccgacct gataaccgcc tttcagcatt tcttggactg 3192241 tcacgagaag cccgtaagtc ccgatgcggt ttgcgataaa gttcggtgtg tcctttgctg 3192301 taacaacgcc tttcccgagg acattttctc cgaaagctgt cataaacttt aaaatatcag 3192361 gatccgtttc cttaatcgga atgatctcta gcagctttaa atatcgtgcg ggattaaaaa 3192421 aatgcgttcc aagaaaatgg gctttaaaat catccgaccg gccttcagcc atttcctgca 3192481 ctgatatgcc ggatgtgttg cttgagacga tgcttccagt ctttcgatgt tcatccacaa 3192541 gagcgaaaat tttctttttg acttcaaggt tttcgacaac gacctcaata atccaatctg 3192601 cttctttcag tttttctgca tcatcctcca gattgccagg tgtaatatag gaggtatttt 3192661 tcgctgatgt gaggggagcg ggcttttgtt tcagcagttt tttcatcgcc tgccggctca 3192721 gcctgctgcg cacctccgaa ctgtccttcg tcagcccctt tttttcctct tcctttgtca 3192781 aatcgttcgg cacaatatct agcagcagga caggaattcc gatgttagcc aaatgcgccg 3192841 ctatcccgga acccattacc cccgatccta aaacggctgc cttccgaatg tgtttgtgca 3192901 tgagatatcc cccttgaaca ttgaatgaat agtcattcat tttttgacta aaaaaaatga 3192961 aacccgtttc ttctttcatc ttaaaagatt tccggttcga cttcaatagc taatttgtta 3193021 tttttttgta tgaagcctat aaaagtcggg caacttaagc ccggaggtga agggaatggt 3193081 acgagagaaa aaaaatccgt cttcagcggc agtcagcgcg gcgagcgtaa agggagatgc 3193141 cggtccgact cagcattacg gcggcggaaa acggacaagt caaaatcagc agtataaaaa 3193201 acataacatg ggacaatcat aatgcagctg cttcccacgg ctgctttcac tttttcaaaa 3193261 ttccttttaa cacaaacgct gcattggcag gccgttcggc aattcttctc ataaagtagc 3193321 tgaaccagtc cgttccatat gggacataca cacgcattct gtagccttcc ttggcgagtt 3193381 ccttctgacg ctccggcctg atgccgtata gcatttgaaa ctcaaattgc gatgcgggga 3193441 tttgatgttc ggcgacgagc tgtttcgtaa atgcaatgat gtcatcgtca tgtgtggcga 3193501 cagccgtgta gttcccgctt aacaactgca gctttattaa gctctgaaaa tgaaggtccg 3193561 tgcctctttt gtcgggaaac gctacagccg cagattcttt ataagcgcct tttacaagtc 3193621 tgagattcgg ctttaagtcc cgcatctttc tgatatcttc tgccgcccgg tacaaatacg 3193681 cctgaatgac cgtgccgagc ttctcaaatt cctgtttgca ttgcctgtaa atagaaagtg 3193741 tctgttcata atgagaatag tcttccatat caatggtcac agcaacatca tattgcttcg 3193801 caacggaaag aatggcgcgc aaatgagtaa gagcaagttc ttctgaaaga tcgagcccga 3193861 ttgaggtcag cttaagtgaa agctctgaat tcaattgatg ttcggcaatg gcttgaatgg 3193921 ctttcttgca ttcctctgcg acttggtttg cttctttttc cgaagctgca tactcgccta 3193981 aataatcaat tgttgcacac aaaccggatc tgtttagcct tttgacggtc ttaaccgccg 3194041 attcaatcgt atcccctgcg acaaaccttc gtgctccaag ccgcgttccg tatgcttttg 3194101 cgaacttggt aagtgtttta ttttgagata agaataaaaa cacatgtctc aacatccgac 3194161 tccctcccgc cgtcatcttc aaaacacctg tatataactc ccagtctgaa ggaaactata 3194221 aaatgaacag aaaccaaagg aggatcacaa tggataatca gcagcaatct caaatgccgc 3194281 cttccgttat ttcgacaaag gatcatttgt atctcaatga catgctgaac tggaatttgc 3194341 tcgcgatgaa aaaagcgcat ttcatggcgc agcagtgcca ggatcaaacg ttaaagcaag 3194401 aactcgaccg cgtcggacac atgcatcatg atcactatca aagaatatta aagcacctgc 3194461 agccaggcca gcagcagtcc ggctacatcc aataaggagg cgccagaatg aatcagcaaa 3194521 atcaaaaaat cagcaacccg cagacacctg taccgacaac atcggaaatg aatgacagag 3194581 atttcgtcaa cgaattgctg acaaccgaaa aatacatgac aacagcttat tgcactgcct 3194641 tgcacgaatt cagccacgag tctctttatc aggatattca atccattttt gatgagtcac 3194701 aaaaagcgca aagaaaacta tatgatctca tgttccaata tggatggtat tctgttgaag 3194761 cggaggattc acaaaagctg cagcagtcct atcaaaaatt ccagcagacc attcagcagc 3194821 agtctcctta tcagcaataa caacattagt aaaaaggata cgatgttctt tcgggcatct 3194881 atcctttttt tgtgtaaaat cagttgactt ttcatttacg cttatttata tttaataagc 3194941 attaactatt ttgtcattaa aatatatata cagtgtatgt aacagagggg aaatgaatat 3195001 gaagagtgcg gatcagttaa tgtccgatat tcaattatcg cttcaggcgc tctttcaaaa 3195061 gatacagcct gaaatgctgg aaagcatgga gaaacaaggt gtcaccccag cgcagctgtt 3195121 tgtgctggcc agcctaaaga aacacggcag cctcaaagtt tctgaaattg ccgagcgtat 3195181 ggaggtgaag ccaagcgcgg tgacgctgat ggcagatcgc cttgaacaaa aaaatcttat 3195241 cgccagaaca cacaacacaa aagacaggcg agtgattgat ctcagtctta ctgacgaagg 3195301 agacataaag ttcgaggagg ttttggcggg cagaaaagcc ataatggcgc gctatctttc 3195361 ctttttgacg gaggaggaaa tgctgcaggc ggcgcatatt acagcaaaac tcgcacaagc 3195421 agcagaaacg gatgaaaagc aaaacatgaa aagaggaaac ggatgaaaat gagtaaagaa 3195481 ggcaaacaat caaaacgaac gttattaata acaggcttaa ttattgccat gtttttttca 3195541 gcccttgacg gtaccattgt cggaacggcc atgccgaaaa ttgtcggtga tctgggcggt 3195601 ttgagcatga tgacctggct gacaactgca tatttgttaa catcaacaac cattgttcca 3195661 attgccggta aactggctga tttattggga cgccgcattg tctatgtatc aggtttgatt 3195721 atttttatgg ccgcttctgc tttgtgcgga atggccaaca acatgacgga attgattatc 3195781 ttccgtggac tgcagggcat cggcggaggc atcatgatgc cgatggcgat gattgtcatc 3195841 ggtgacttgt tcacaggaaa acagcgtgct aaattccaag gtgtctttgg cgcaatttac 3195901 gggctggctt cagtgattgg gccgcaaatc ggcggctgga ttgtagactc gttaaactgg 3195961 aaatgggttt tctatattaa cctgccagtc ggaattattg cggttatttt tattgccagg 3196021 ggattacagg gacgccagca gactggtccg atcaacttcg atatcgctgg tattttcaca 3196081 atgattgtcg gtgtggtcag cctcctgctc gccttaagct ttggcggaaa agattatgca 3196141 tgggattcat ggcagattct tgggttgttc gctctcgcac tgatcggcat tgtcagcttt 3196201 atcatcgtag aatcaaaagc aaaagagcca atcctgccaa tgtatttatt taaaaacaga 3196261 acatttacat ttctaaactt gatcggcttc tttatgagta tcggtatgtt tggcgccatt 3196321 acgtttgttc ctttctttat gcagggaatt gtcggtgtaa gtgcgtctga atcgggtaca 3196381 attatgacac cgatgatgat ttctatgatt atcacaagta tcatcggcgg acagcttgtt 3196441 tataaaattg ggattaaacc gcaaatcatt acaggcatgc tggttatggc cggcggattc 3196501 ctgctgttaa cgacattgga tctcgacacg agcaagcttg tcgctacatc ttttatggcg 3196561 attattggtc tgggaatggg tcttgttatg ccgattctga cattggcttt acaggaaagc 3196621 ttttcgaagg aggagcttgg agttgtcact tcatccagcc aattcttccg ttctatcggc 3196681 ggaacattcg gcattaccat gctgggagcc gtaatgaatg cgagatcagg aaatctatta 3196741 acagataaat tggttccata tttagactct cttccggcac aggcaagctc gtttgccgcc 3196801 cagctaaagg gtatgattga tacaaatccg caagggctgc tgcaatcact gttcagtccg 3196861 gacgcggtca aacaaatccc tgcggctttc tcatcccata ttgtgccgat tttaaaaaca 3196921 tcgttgatgg attcgctcca cagcgtgttt tatacgggcc tgatctttat cgcagtcgga 3196981 gccgtattca ccttgttctt aaaacctatc aagctatcaa ataagaaagc ggaagaccaa 3197041 caagaaaaag agaaggcggc aaaagccgtt gaatcacctt cccattaata gagcaccccg 3197101 cgggtatcaa tccgcggggt tttttattca atcatctggg ctcttccatt tccgaaagac 3197161 caatcctcat cctgatttcc ggccagcatg ataaacacat cttcttttct tacaccaagc 3197221 tcggaatgaa tccggctcgc gattgagcgg taaagtgctt ttttctgttc agttgttctt 3197281 gactgtttca gtgtaaaatg aatgtatatc agttcatcag tacgctcgac ttggagataa 3197341 aatggatcat aaaaaaattc gcttttttca tattgtctga tgacttggaa atagtcatct 3197401 tccggcacat tgatttcttc aatcatcgat tggtggatag tcctgctcag tttttgaagc 3197461 cacacttcgc ttcttcccga ccgtaaatga atctgtacaa atggcatctc cccgcatccc 3197521 tttctttaca gcgtctgtcc gctgtcaatt gtgataattt ggcctgtgag tgattcctgt 3197581 tcaattagtg aacaaatcaa tttggcaaca tcatctggtt cagcaataca ctgcagcagc 3197641 aaagagccga tcatgctttt cattttttct tcccgtccgg cccaccatct cgttgccaca 3197701 gctcctggtg ctacaccgct cactctgatt tcaggcgcta aggcgtgggc caatgatttc 3197761 gttaaaccgt gcaccgctga ttttgatact gcgtaaggca ttgatgagcc ggcaccagtt 3197821 atccctgcga tgctgccgac gtttacgatc gccccgtcct tgcttttctt catgaacgga 3197881 accactgccc gcgcgcagaa aaacatccct ttcacattga cggcatacag ctcatcctag 3197941 acgtcttctg tcgcagcctc aagatcatcc attggaatat gccgtgtaat gctggcattg 3198001 ttgactaaaa tatcaaccgt gccgtgtgtg ttcacgattg cttgaatcat atcctgcacg 3198061 tcgctgtttt tggatacatc tgcttggatg gcgaaggctt gcccgccagc tttttgaatc 3198121 atttccactg tttcctccgc ttctgattgc gagcgtgaat aattcaccgc cacaatcgcc 3198181 ccacgctttg ccaattccat actggctgct tttccgattc ctgtgccgcc ccccgttacg 3198241 agagctattt tgttcaagac attcattgcc gccactcctt gctgttgact aaagtatatt 3198301 tctgattcca ttgtaatcca gctttgatgt tacgtataat gattgttaaa gatactagat 3198361 atcactcaga ttgatagtaa acgaacggag gagttcaaaa tggaaagcgg agatttacgt 3198421 gtgtttcaaa tggtagctcg tgaagggacc attacgaaag cagccctgca gcttggctat 3198481 gtacaatcga atgtcacggc cagaattcaa caattggaag ctgagctggg taccacactg 3198541 tttttgcgcc ataatcgggg catgacactt tctgcaagcg gaaaattgct gctggactac 3198601 gcaaataaaa ttataggcct tcttgatgaa gcgtctaaag cgctctcatc ctccgcagaa 3198661 ccaagcgggc cgcttatgat cggctgcact cagacaaccg ccgcggtaag gcttccaaag 3198721 cttctggcat cttattatga agaacatcca aacgtccagc tgtctttaac aacaggacat 3198781 acgcaatttc tccttgataa agttcttcgt tatgaattgg atggcgcgtt tatcggatgc 3198841 gaatgccatc atcctgagct cgaatcctat cctgcgtttg aggaagaacc agtagttgtt 3198901 tcggctgcct ccgtgcccga tgttgaggaa gccatcacaa agccgattct cgtttacagc 3198961 acaggctgtt cgtatcgaga aacacttgaa aaatggctgc gttccgtcgg tgtcacacag 3199021 ccggtcatta tggaatttgg gacgcttgaa gcaattatcg gcggggttac agcaggtctt 3199081 ggcatctcgt tgctgccaag aacggttgtg cagaaacatg aagcagaagg atcaattcga 3199141 ttgtacccgc tgcctgaagc tctcagccag atgaaaacag agtttattgt tcgaaaagat 3199201 tcgtttatca gcagcgcgct gagaaccttt atggattcct ttacgccagt taaaacggct 3199261 gaatcacaaa aaagcagtct gctataatga acagactgct ttttggctat tgtttgtttc 3199321 gatgcgcttc atttaattcc ttaatatgct gaatgatctc tttaatgccc tgcttcgcgt 3199381 cggggtatgt cgcattccaa tgcttagcga gcggaggcat gcttttggct atatgggtgt 3199441 acaaaatcca ttgcttcact tcttctttta gctcatcgtt tgtttcacca agcagaagct 3199501 cagtatactt ctccagcaat ccatcaagct gctcctgaag tttttgttcc attttccatc 3199561 ttcctttcga aaaaacagca aggagctttc tcaattgaaa gctccttcgc tgcgttattt 3199621 atccatgtga tgtgaaagcc gcttcctgga caatgcatct gcccctgcca tgaggaatgc 3199681 aaagaggcgt tccgaagagc gggtcctgtg taacctgaca gttcatagaa aacacatttt 3199741 gcacaagatc acaagtgatg acctcttccg gacggccttc tgcataaatc cgtttatctt 3199801 ttatggccac aagatgatgc gcatagcggc acgccaagtt taagtcatgg agaaccataa 3199861 caatcgtccg gtcttccttt tcattcagct caaacagcaa atcaagaatt tcaatttgat 3199921 gcgtcatgtc taaatacgtc gtcggctcgt caagaaggat gatatccgtt tcctgggcaa 3199981 gcgtcatcgc gatccaagcc cgctggcgct gtccgcctga caaagaatca acggcacggt 3200041 cagccatgtc ctcaagcttt gttgctttaa gcgctctttc aactgcttcc tcatcctctt 3200101 ttgaccactg cttcagccag ttttggtaag gatatcttcc ttgcttcacc agctgatgca 3200161 ccgtcagccc ctctggagcc gaaggacctt ggggcaggat tgcgagctct tttgcgactt 3200221 ccttcgtcgg aagcttggca atcgctcttc cttccagcag cactgaaccg cctctcggct 3200281 tcatcaggcg cgctaatgaa cgtaaaagtg tcgattttcc gcagccattg ctgccaataa 3200341 atacggtaat ttcacctttg ggaattgtta aattcaactc atcaataata acggcatccc 3200401 cgtatcctaa gctcagcgtt tctgtagaaa ttgcactcat acccataacc gctccttttt 3200461 gctggctttt tagcagcact atgtattgca cgttttctat atacatgctt ttaagtcaat 3200521 tgtcatcaat gcaaatgatt ccgatattca gccatttgat atggtcatat atccctcatt 3200581 gtagcagaaa acactgactt tgaaaatcat tttcaattag ttttatggac ataattgacg 3200641 tttatgggtt ttttatcaca agattacttc ttgatttctc tgatggagcc gtccttcagc 3200701 ttcaatttta aatcgatatg atcataatga ctgtccagat taaatgctgc cagcacactg 3200761 tgtatcactt ctgtttcagc catttggtct gtcacggaaa gctcgctcaa aatcattttc 3200821 atctcatcta acgcttcttc tccttcctga ttgacaccgg agagcttatc ctgtatttcc 3200881 gctttttcct gagtcccgtt ctttgtatag attccttcat aacggttatg ctcaccatcc 3200941 ccgtagctca cacgaagcga aaaattactg tagggaacgg acttcagctg ggtgacggct 3201001 gtattttctc cttctgcctg atgctggtct tcattgaaac ggcagcccgc aatcagaacc 3201061 actgcgagac atacagcccc ggctgctctg atcaaatgca tatgtttccc ccctgtagga 3201121 ttccatttat tttaggtata tccagagaat gaaatcctca ttcagagaag aattgaaaaa 3201181 gccggggcat ttaacgccac ggctttttct ttaagattcg gtcatttgta aaaaggtttc 3201241 ggcgtcacgc acagccagct tgatggcatt ctcccagaaa tcgcgctttg tgatgtcagc 3201301 gcccaaatgc ttcatcgcca aatcctccac tgtcatagaa gccgtatcgc gcaatagcgc 3201361 catatacttc tcttcgaatg tgtctttttc ttcaagcgcc aacgcgtaaa taccaagaga 3201421 aaacaggtag ccgaatgtat aagggaaatt gtaaaacggc accctcgtga tgtgaaaatg 3201481 aagctttgat gcccaaaaaa gcggatgata ttcttctaac gcattgcagt atgcctctct 3201541 ttgcgcctct tccatcagct cattcaagcg gctggccggt accactcccc gctttcgttc 3201601 ctcgtagaat ctcgtttcaa atagaaatct tgcgtgaatg ttcatgaaga acgcaacgct 3201661 tctttgcact ttatcctcca gaagaacaag cttttcttcc ctcgtctcgg cctgctggac 3201721 agtcgcgtcc gccactatca tctctgcaaa cgttgaagct gtttctgcaa cgttcatggc 3201781 gtaggaacgg tttaacggcc tgacgttgag cattgcttcc tgatggaacg cgtgcccgag 3201841 ttcatgcgca agggtagaga catttgaggc gcttcccgaa aatgtcatga aaatccggga 3201901 ttccccgctg tccggaaaac tggtgcaaaa gccgccgact ctttttccgc tcctgtcttc 3201961 cgcctcaatc cagccgtccc gaaacgcttt ttcagtgaat gaggacagct ttttgccaaa 3202021 cgttgaaaac tggctggtaa tgatatttgc ggcttcatca tacgaataga cctttccgtc 3202081 agaaccgatc ggtgcctcga catcgtacca gctgagtttt tcaaggccga gcatggatgc 3202141 tttccggttc aaaaactgaa cgaacggctt cttgttttca gtgatgacct gccacatcgt 3202201 atcaagtgtt tcttttttca tcctgttaat ttgcagcggt tccttcagga cattctccca 3202261 gccgcgcgct ttataggttt caagccggaa tcccgccaaa tgattcagcg tgctgctgaa 3202321 aatatcttgc ttgctctccc aagcttggcg gaaacgttca tatactgttt ttctgacagt 3202381 acggtcttga tgatccatca tattctccgc ctgaccgaca gacaattgct tgttttcacc 3202441 gttttcctca tacgggatcg tcattttccc gacaaccata ttgtataagt cactccaagc 3202501 gtgatatccg tccaccgcaa ggtttccgat cagtttttcc ttaccggggc taagcttttc 3202561 ggcaaccctc tgtcttcttt catttaatat gtaagaaaca tcgcgcaatc ccggttttgt 3202621 taacaattca ttccacacgt cttgattaat gtccacaagt ttatgatcta atgtaacgag 3202681 cgacgattga aaatctgcgg aaagccgatt catgaggcct gatgctctat agccttttga 3202741 tcattgatat tctgggcctg gaggcaagca acaaaagcgc cggcctgctg aagcttgacg 3202801 gatgtctgtt cgaataaatc aagcaacgcg gtcagccctt cagcctcttc aggcgattca 3202861 ggcacctgaa acgcatcagt cctgtcttga aatgcacgca gactttgtga cagcttctca 3202921 atataacctt tgaattcttc cgattggctc ccgcccttaa aaaatgaatc aagatcccat 3202981 ctttggccta ccccttgcag cgccatatca caaaacccct ttccttcttt cgttctatta 3203041 tagaacaatt ctgaattatt gtataaaaat ttctattaca ggcgtcattt cgtgttcagg 3203101 atagtacaat agctgtagca gtttaatagg agggttagga tgaataaaaa aatagccatc 3203161 gtgacaggag cgtccagcgg cttcggtctg ctggcagctg taaagcttgc ccgatcattt 3203221 ttcgtgatag ccacatcaag acagcctgaa aaagcggaac agcttcgaga attggctgca 3203281 gcacacaatg tgtctgattc tattcacatt acagctctcg atgtcaccga tgaacaatct 3203341 atagtctcat tcggaaaagc tgttagtgct tacgccccga tcgatttact cgttaacaac 3203401 gccggaacgg cttatggagg atttatcgag gatgtgccga tggaacattt cagacaacaa 3203461 tttgaaacga atgtcttcgg tgtgatccat gtgacaaaaa ccgtgctgcc ttacataaga 3203521 aagcatggcg gcgcaaagat tataaacgtg agcagcatca gcggactgac aggattccca 3203581 gcgctgtcgc catatgtttc ttccaagcat gcattggaag gtttttctga aagcctgcgt 3203641 atcgagctgc ttccgttcgg tatcgaaacc gctttgatcg agccgggctc atacaagaca 3203701 tcgatctggt caacgtcatt atcaaatttt atgtcggtgc ctgctgacga ttcagcctat 3203761 catcaatact ataaaaagat cctttcctat gttcaaaaaa acggagaaga aagcggagat 3203821 ccccaagagg ttgccgacct catttatcaa ttggcaacaa aacagcacat aaagaatttg 3203881 cgatacccga tcggaaaggg catcaagctc accctgctgt tccgatcgct ttttccttgg 3203941 tctgcgtggg agtctatcct gaagaaaaag ctattcagct gatctaaatt ataattatta 3204001 taatttagta ttgattttta tttagtatat gatataatta agtcaacaga tcacaaggag 3204061 gacgttatct tatgaaaact gaaaacgcaa aaacaaatca aacattagtt gagaattcac 3204121 tgaacacaca attatcaaac tggtttcttt tatactctaa gctccaccgt ttccattggt 3204181 atgtgaaagg gcctcatttc tttacattgc acgagaaatt tgaagaactt tatgaccatg 3204241 cggctgaaac agtggatacc atcgctgagc gcctgctggc gattggcgga cagcctgttg 3204301 ccacagtgaa agaatacact gagcatgcat ctatcacaga cggcggaaac gaaacatcag 3204361 catcagaaat ggtacaagca ttggtaaacg actacaaaca aatcagcagc gaatctaaat 3204421 tcgtgatcgg cctggctgaa gaaaatcaag acaatgcgac agcggacttg tttgtcggat 3204481 taattgaaga agttgaaaaa caagtgtgga tgctttcctc ttatttaggg taacaaaaaa 3204541 gctgaacctt aatcgggttc agctttttgt tttttcttag cttgaactgc tttctgtctg 3204601 cttggtcagt gttgcgttca acgttttcgt ttttcccttt cgcagcactt ggattgttgt 3204661 tttatctccg acttttaagt ctttgtaaag gatctgacgg atatccgcac tgctttccac 3204721 gtctttaccg tttagtttga caatgacatc ctcagattta atacctgctt tttctgccgg 3204781 cgaatttgct tgaacttctt ttacataaac acctttgccc aattgatctc caaacaggcc 3204841 gagcgtattt tcctgatagg tttcaggaac ttgtgacatg tcaatcatct gcacgcctaa 3204901 aaacggacgg tccaccttcc cgttttgcag cagctggtca acaatcggct cgacatcatt 3204961 gcttgggatc gcaaatccaa gtgattccac gccgctttcg ctcaccttca agctgttgat 3205021 gccgatgacc tggccgcttg cattgattaa tgggcctccg ctgttccccg gattgatcgc 3205081 tgcatcggtt tgcagcacgt tcatttccac cgtcccctgt gttgtatcca catcaattgt 3205141 ccggttcagt ccgctaatga taccttgtgt cactgtaccg gaaaactgct gtccgagcgg 3205201 gttaccgata gcgattacct tttcgccagt gcgcagctgt gaagagtcac caaagctcgc 3205261 cacttttttt acattcttgc cgctgatttc caaaactgcc aaatcagtaa tggtatcgct 3205321 gccgacaagc ttggcagttt ccgtttctcc gttgtatagc gtaacagtca gcttgttcgc 3205381 gccttcaacg acatggttgt ttgtaatgat atacgcttta tcgctgtctt ttttgaaaat 3205441 aacacctgac ccggttccgc tttcactttc tgagctggag cctcctcccg tgccgaatgt 3205501 gttattttga gaggtttgga tatttgagat tccgacaatc gtaggctcta aatcctctac 3205561 catatcagcg atgtttgatg cgttcgttat cggcgccgtt gtaaaattat cagactgcac 3205621 ctgtttattt gcggaagcgg tttcggtcgc ctgattttgg tctgacggca gataaggcgc 3205681 gatgccaagc atgaggcccc cgccgataat accgcctaaa atcgggctca gccatgcggc 3205741 tctccgtttc ttttcttttt tcacagccgt ttcttgcttt tccatttcta aagcagaagc 3205801 cgtttcctgc cgtcccgctt catacgacac aggcgcgtca agcaattctt gttcagaatg 3205861 tccaatcagc ttctggtttt ctgtattctg ctgttctgta tgtgaaggtt cagtttgatg 3205921 ttgatcgttt tggccatcac gtcgataatc catgttctta cactccttta acggttattc 3205981 atttatcgtt acatattcat cgcatgtaca agttcaattg tcccaataat gaggagaaaa 3206041 gcaaagcacc aaaatagaat atgtttgatc atcctacatc ttcctcgctc tttttctctt 3206101 cctttcttcc cttaaccata tcataaacaa acattgtggg ataaaaatga aaagaatatg 3206161 tgaaattatg aaaattgcct gccgtatgtt aaaactagtt tataatgacg ttgaaaggat 3206221 gtgaagagcc ttgtcataca ccatttatct agttgaagat gaggataacc tgaatgaact 3206281 gctgacgaag tatttagaga atgagggctg gaacattaca tcttttacga aaggtgaaga 3206341 cgccagaaag aaaatgacac cgtctcccca cctatggatt ctcgatatca tgctgccgga 3206401 taccgacggc tatacattaa taaaagaaat caaggcgaaa gatcctgacg tgccggtcat 3206461 ttttatttcc gcccgagatg cggatattga cagagtgctt ggcttagagc ttggcagcaa 3206521 tgactacatt tcaaagccgt ttttgccgcg ggagctgatt atccgtgtgc aaaagctgct 3206581 gcagctcgta tataaggaag ctcctcctgt ccaaaaaaat gaaattgccg tctcctcgta 3206641 tcgggtcgct gaagacgccc gcgaggtcta tgacgaaaac gggaatatca tcaatttgac 3206701 gtcaaaggaa tttgatctgc tgctattatt tatccatcat aaagggcatc catactctcg 3206761 tgaggatatc ctcctaaaag tgtggggaca tgactacttc ggaacagacc gggtcgttga 3206821 tgatctcgtc cggagactgc gcagaaagat gcctgaattg aaggtggaga cgatttacgg 3206881 tttcggctac aggatgatgt catcatgaaa aacaagccgc tcgcgtttca gatatgggtt 3206941 gtcatatccg gcatcctgtt agcgatatcg attttactgc ttgtgttatt ttcaaacacg 3207001 ctgcgagatt ttttcactaa tgaaacgtat acgacgattg aaaatgagca gcatgttctg 3207061 acagagtacc gcctgccagg ttcgattgaa aggcgctatt acagcgagga agcgacggcg 3207121 ccgacaactg tccgctccgt acagcacgtg ctccttcctg aaaatgaaga ggcttcttca 3207181 gacaaggatt taagcattct gtcatcttca tttatccaca aggtgtacaa gctggctgat 3207241 aagcaggaag ctaaaaagaa acgttacagc gccgacgtca atggagagaa agtgtttttt 3207301 gtcattaaaa agggactttc cgtcaatgga caatcagcga tgatgctctc ttacgcgctt 3207361 gattcttatc gggacgattt ggcctatacc ttgttcaaac agcttctgtt tattatagct 3207421 gtcgtcattt tattaagctg gattccggct atttggcttg caaagtattt atcaaggcct 3207481 cttgtatcat ttgaaaaaca cgtcaaacgg atttctgaac aggattggga tgacccagta 3207541 aaagtggacc ggaaagatga aatcggcaaa ttgggccata ccatcgaaga gatgcgccaa 3207601 aagcttgtgc aaaaggatga aacagaaaga actctattgc aaaatatctc tcatgattta 3207661 aaaacgccgg tcatggtcat cagaggctat acacaatcaa ttaaagacgg gatttttcct 3207721 aaaggagacc ttgaaaacac tgtagatgtt attgaatgcg aagctcttaa gctggagaaa 3207781 aaaataaagg atttattata tttaacgaag ctggattatt tagcgaagca aaaagtgcag 3207841 cacgacatgt tcagtattgt ggaagtgaca gaagaagtca tcgaacgatt gaagtgggcg 3207901 cggaaagaac tatcgtggga aattgatgta gaagaggata ttttgatgcc gggcgatccg 3207961 gagcaatgga acaaactcct cgaaaacatt ttggaaaatc aaatccgcta tgctgagaca 3208021 aaaatagaaa tcagcatgaa acaagatgat cgaaatatcg tgatcaccat taaaaatgac 3208081 ggtccgcata ttgaagatga gatgctctcc agcctctatg agccttttaa taaagggaag 3208141 aaaggcgaat tcggcattgg tctaagcatc gtaaaacgaa ttttaactct tcataaggca 3208201 tctatctcaa ttgaaaatga caaaacgggt gtaacatacc gcatagcagt gccaaaatag 3208261 actgtagatg ttttgcagtc tattttttta tgtgaaagaa tagccgttaa aatctctgta 3208321 atttgttttg agcggctgtt tgcattgatg aacccatttt ttctctgaca aggtctgctt 3208381 cggatatttg actttctcca ctttgattcc tctgtttcgc aagcggctga tcatttcgtc 3208441 caattctctc attctagatt caccctttcg cttgagcttt gaccattcgg tcatctcaat 3208501 ttataatata aataatacat gataaaaaaa caagttacaa taaggttaat tttataacag 3208561 acggtgtgac tatatggtca tatcctagca ggcctccggg ctccgaaagg gtggaaccat 3208621 tgaaggaaaa agaaaaactg attattgaaa cagccttaaa actatttgcc caaaaaggat 3208681 acaactcaac atcagtccag gaaatcgcaa aagaatgcaa aatatctaaa ggcgcttttt 3208741 atatttattt tccttcgaaa gaagcgcttc ttctctctat gctgaactac tattatgata 3208801 aaacgtttac ccgaatttta aatattaaaa cgaagggcga cagccccaga acggcttacc 3208861 gtaaacagct gaccgtcctc tatgaaaaca ttcttgaaca caaagatttt atcagcatgc 3208921 agttgaagga gggttctctg ccttacacag aagaagtgga gcaatgcgca aaaaaaatcc 3208981 gccagtcctc acttcaattt catatcgaca gcctgctgaa catctatgga aaaaaagcgg 3209041 aaccgtacac tgctgagctt tgttttttaa tagagggcat cagccagatt tacctggaat 3209101 gcatgatttt gctcgggtac actgtgaagc cgtctcaatt agctgatatc attatgaatc 3209161 gaattgatga tatggtaaaa ggcatgtctg aacgaaacga taagcctttc atcacattgg 3209221 aagaggcgag ctctttattc ggacctctta cgcacggacg gcctgacccg ctgactgaat 3209281 caattgtgaa aagcctacgt gacaaaatta acagcttaaa cacaaactcc tctcttgaat 3209341 tatcggagag cttggacata cttgaagcag aaatgaagaa aaaaacaccg aagctggcga 3209401 tcataaaagg aatgattcat aatctgacgg agtctgaagc tctcgccaaa gatgcggaac 3209461 agcttaaata tttattaaaa cagcaacata tttagaagaa cggctgctta aaaagcagcc 3209521 gttcttccta ttacgccttt ggttttacca tgtcttccgg cttaaccatt tcgttaaatt 3209581 gctcctctgt cagcaattca agcttcaaag ctgcttcttt gagcgtcaat ccctctttat 3209641 gggcaagctt ggcgattttc gccgcgtttt cataaccgat atgcgggttc agcgccgtaa 3209701 caagcattaa tgaatttgac aggttttcct gaatggtttc tttattaggc tcaataccga 3209761 cagcacattt atcatggaat gaattcatgc cgtcactgag cagctgcaca gattgcagga 3209821 agttgtaaat aataacaggc ttaaacacgt tcagttcaaa gttcccctga ctcgccgcaa 3209881 agccgattgt cgcatcgttc cccatgattt gcgctgcgat cattgttaac gcttcgcttt 3209941 gtgtcggatt gactttacca ggcataatag agcttcccgg ctcattttca ggaatgacga 3210001 tctccccgat gccgcagcgg ggtccgcttg cgagccatct gacatcgttc gcgattttca 3210061 ttaagtcagc cgcaagcgct tttaatgcgc catgcgcata agtgatttcg tcatggcttg 3210121 tcagcgcgtg gaatttattc ggcgagctgc tgaacgtttg gccggtcagc ttagtgatct 3210181 cttctgagac aagctctcca aactctgggt gggcgttgat acccgttccg acagccgttc 3210241 caccaattgc aagcgcacgc attttatctg tcgcttccaa aatcatttcc ttcgaacggt 3210301 ccagcatgtg aacccatccg ctgatttcct gtccgagggt cagtggcgta gcatcctgaa 3210361 gatgcgtgcg tccgattttg acaatatcat tgtatgcttt tgctttttca tccagtgtat 3210421 tgcgaagctg atcaagcgcc ggcacaagct gctcgtaaac agccaaaaca gcggcaacat 3210481 gcatcgcagt cgggaatgtg tcgtttgagc tttggcttcg gttcacgtca tcatttggat 3210541 gaatcgtttg atcagagttc ttctctttta ataaagcagt cgcacggttg gctaccactt 3210601 cgttcatgtt catattgctt tgtgtgccgc ttccggtctg ccatacgaca agcgggaagt 3210661 tgtcatcgta cttgcctttg agcacatcat cacaaaccgc tgcaatcgct tctgcttttt 3210721 cagcgtccag attgccgagg cgtttattag ctagagcagt gcttcgtttt aaaattgcaa 3210781 acgccttcac aacacgcatc ggcatttttt cagaaccgat cttaaagttc tccttgcttc 3210841 gctgtgtttg ggcgccccaa aatttatcag caggaacttt tacttctccc atggtgtctc 3210901 gttcaattct gtattccatt tatgtatccc tccataacgg ttgcttcaat agatcataat 3210961 tcgccaatga cacaaaaaat cctttttatt tttcgatctt ggcagatttt aattttaatt 3211021 caagatatac gcgggaatcc tttgaatatt tgtattttgg atttgtcctg ccgtactcct 3211081 ttgatgtata agagacatca taatgctgtt caaatgatct aatgagctgt tcaatttctt 3211141 cttgttttcc agctagcctt acctgtgcca cttcgtatcc tccgctttca taaaaaaact 3211201 tactccatga aatactctaa cacagtatat cattttttta acaggaaaag ataacctcta 3211261 ctaaggtttt ggataagagg tgacctcatt ggaacaaaca gagtttaagg aatatataca 3211321 cgataattta gcattggtgc tgccaaaatt aaaagaaaac gatgatctgg tgaaaaacaa 3211381 aaaaatgctt gcgaacggac tggtttttta ctatctctat ttcagtgaaa tgactgatga 3211441 gaataaggtg tcagaagcca ttaaaacttt gattaaagat gaggagacct taacgcttga 3211501 ccaggtcaaa aaacgccttg accagcttga cgcaagacct gttgaaactg caaaaaaaac 3211561 gattgaatcg attctcaacg gcaattgtgc tgtgtttatc aacggattgg ataaagccta 3211621 tattctgacc acaggaaaga aaaaaacaag aagcctgaca gagccgacaa ctgaaaaagt 3211681 ggttcgcggc ccaaaagtag cgtttgtaga ggatattgat acaaatctcg ctctgatcag 3211741 acaaagaacc tctcatccga aattgatcac caaaaaaatc atgatcggcg aaaacaagct 3211801 gaagcctgca gccattatgt acattgaagg caaagcaaaa aagtccgtca taaaagaagt 3211861 gaaggcgcgg cttaaaaata tccagctgga agatatccag gacagcggaa cgctcgagga 3211921 gctcattgaa gataataaat attcaccatt tccgcagata caaaatacgg aaagacctga 3211981 caaagtatct tcagccctgt ttaacggccg tgtggcaatt ttggtcgaca gttcaccatt 3212041 tgtgctgctg gtgccggttt ctctcggcat cctgatgcaa tccccggatg actactatga 3212101 acgctggatt tcagcatctc ttatccggtc gctgcgcttt gcttctatct ttatcacctt 3212161 gtttttgtca tcgatttata taacacttgt ttccttccat caggggctgc tgccgaccgc 3212221 actcgccgtc acgatttcgg cgaacaggga aaacgtgccg ttccctccga tatttgaagc 3212281 cctgctgatg gaagtcacca tcgagctgct aagggaagcc ggactgcgac tccccaatcc 3212341 gctcggacag acgatcggcc tcgttggggg cgtagtcatc ggacaggctg ctgtagaagc 3212401 gaatctcgtc agttcgattt tggtcattgt cgtcagtgtc attgccctgg catcctttac 3212461 cgttcctcaa tacggaatgg gtctgtcttt ccgggtgctg cgttttattt cgatgttttc 3212521 cgccgctatt ttagggctat acggcattat tttatttatg cttgtcgttt atacgcactt 3212581 aacgagacaa acgagctttg ggtctccgta tttttcgcca aacggattct ttagcctgaa 3212641 aaatacggat gactccatta tccgtctccc aattaaaaac aaaccaaaag aggtgaataa 3212701 tccaaatgag ccaaaaacag actccactga aacttaatac ctttcaaggt atttctattg 3212761 ttgcaaatac aatgcttggg gccggacttt taacattgcc gcgagcgctg accactaagg 3212821 ctaatacgcc tgacggctgg atcacgctga tattagaagg tttcattttt attttcttca 3212881 tttatttaaa cacgctcatt cagaaaaaac atcaataccc ttcactcttt gaatatttga 3212941 aggaagggct tgggaaatgg atcggcagca tcatcggcct tttgatctgc ggctatttcc 3213001 tcggcgtagc cagcttcgag acacgggcaa tggctgaaat ggtgaagttt ttcctgctgg 3213061 agagaacccc aattcaagtc attattttaa cgtttatttg ctgcggcatt tatttaatgg 3213121 ttgggggctt aagcgatgtg tcgcggctgt ttccctttta tttaacggta accattatta 3213181 ttttgctgat tgtgttcggg atcagtttta aaatttttga tatcaataat ttgcgtcctg 3213241 ttttaggcga aggccttgga cccattgcaa actcccttac cgtcgtttcc atctcttttt 3213301 taggaatgga agtgatgctg tttcttcctg aacatatgaa gaaaaagaaa tacacgttca 3213361 gatatgcgtc tctaggattt ctgattccga ttatcttata tatccttacg tatattatcg 3213421 ttgtcggagc tttgaccgct cccgaggtga aaacgctgat ttggccgact atttctctct 3213481 ttcagtcctt tgagcttaaa ggcatattta ttgaacggtt tgaatccttt ttactggtgg 3213541 tctggattat ccagtttttc accacatttg tcatttacgg atactttgcc gctaacgggc 3213601 taaagaagac atttggatta tcgactaaaa caagcatggt gattatcggc ataacggtct 3213661 tttatttttc tctctggccg gatgacgcca atcaagtcat gatgtatagc gattatcttg 3213721 gctatatttt tgtctccctg tttctgcttc cgttcattct ctttttcatt gtagctctca 3213781 agaggaggat tacaacaaaa tgaaaatccg gattttatgt atgtttatat gcaccctatt 3213841 gctgtccgga tgctgggaca gtgagaatat cgaggaatta agcttagtga tcggaatagg 3213901 gctagacaag cctgacgatg aaaatttaga gctgacacag caaattctcg tgccgaaaat 3213961 aatcagcgcc aaggagggct cttcatctga tccgacacag ctttctatca caaagggtaa 3214021 aactgtccat caaatgatga gaacctctgc attaaagcat aagcctacgt tttcacagca 3214081 tttgcgtctc attctgcttt ccaaaagcgt gattgcggat caaattggaa tggacgccat 3214141 tattaaccag tttgtcagag acaacggaac aaggaggagt tcctacgtct ttatcaccaa 3214201 cggccgaact aaggatatat ttaacatgaa tgatgaaggc gaacccgcat ccaacgtgat 3214261 atatgatctg acagagaata ataaggtgac gatcagaacg atggagccag ttacattggg 3214321 ggagatctca gaacacttaa cctctgacga ttcattcctc atccctcatg tcggtaagga 3214381 aaacggcaag ctcgcgataa acggagcctc tatcataaaa aataaattat ggcaccggga 3214441 cctcaccccg attgaggttc aaaatatcag cttattttca ggcactgtcg agggaggcgt 3214501 cattgacttg aagcgcgatg gccatctctt ttcttatgaa gtatattcaa gcaatcggaa 3214561 gatcaagacg gcatacaagg acggaaagtt caaattcacc gttacccgca atattgaagg 3214621 tcgtctatct gaggactgga atcccaatga agactcgttt aaggattcat atattaaaag 3214681 tattgaaaag acagtcgaaa aacgagtaca cgaaacagta acgtcattta ttacagagaa 3214741 gctgcagaaa gagatcaaag cggacgtaac cgggctggga aacgaggtca gaattcatta 3214801 tcctcaaaag tggaaaaaga tttcaagaaa atgggatgat gattatttca gcaatgcgga 3214861 aatagactac cgggtcaatg tgattgtcag agacttcgga acgaaaggcg caaacaaata 3214921 gcagccgcct aattcacgag atgatttcgg tgtgcgtaca ccgccgcctg cgtccggtca 3214981 ctgacatcca gctttgataa aatattcgta atatgtgttt tgactgtttt aatcgtaata 3215041 aacagttcct cgcctatttc tttgtttgtc tttccttctg cgatcaggca gagtatttcg 3215101 agctcccgtt ttgtaagcga ttcatgcggg agcgcgtttt cacctgagtg gcgcagcctg 3215161 gataatactt ttcccgccac ttttgactcc agcttcggct ctcccttgct tgcggcgcgg 3215221 atggcatcgg cgatttctgc cgcttttgag gttttcaaca gatagctgag cgcgccagct 3215281 tcaataaccg ggtacacttt gtcatcatca atgaagctag tgagcacaat aattttcggg 3215341 tcggaaagct cccggcaaat ttgctttgta gcttcaatgc catccatgcc ctccatgaca 3215401 aggtccatta aaatgacatc aggcgacagt tccacagcaa gccgaacacc ttcgctgccg 3215461 tccgatgctt cgccgatgac ttcaatatcg ggctgcgcct ccaaaaaagc cgcgagcccc 3215521 attctgacca tttcatgatc atcaatcaat aatactcgaa tcacgttcgt tctctccttt 3215581 ttcttccgga aaaatcggga ccttcacttc gatttgagtg ccttttcctt ctactgaaat 3215641 cacttcggcg acaccgccga tttcacttgc acgttctttc atagaattca agccgtatga 3215701 ggaggctttc acctggtcca ttttaaagcc ttttccatta tcaatcacct tcagacggag 3215761 ctggctgttc tttatgccca gaatcacggt tacttttgac gcttttgaat gtctaaatac 3215821 gtttgaaagg gcctcctgca cgattctgaa caagtggtct tcaacaccct tggatatcgc 3215881 tgtgtcctgt atatcccact caatatcaat cggctgcttt tttcggaact cgtccaaaag 3215941 ctccgtaagg ccctccttca gcccttttcc ttcaagggta acaggccgta aatggagcag 3216001 cagcgccctc atctcatttt gggcttcgcc tgccatatgc tcgaccatcc tgatccgctt 3216061 gactgttttg tcatcagcat ccttgacatg ttccagcacg gctgatgtca tcatcgatat 3216121 ggcaaagagc tgctggctga ccgcatcatg aagatctctg gccaatcgct ggcgttcttc 3216181 tgagataacc gacttcttca tttgagcctg ccattccgca cgttcattgg aaagtttctg 3216241 gagggatgcg acttgaagct ccacgcgctt cgccatttcg ttcagctgat cagcagccag 3216301 gccgatttca tcatcaccga gcggcggtat ccgataagcg aaattgccgt tttcaaaggt 3216361 taaaatggat tcaattaatg tatcaatcct tgtcttcaac cggttgccgt acatataccc 3216421 tgaggcgaaa ccgacggtca cgctgatcag aagcaaaatc aggataaacg gaattccgaa 3216481 ccagcttgat gacagcaaaa caagcggatc gagccgatag taaaacatca taaaggaaat 3216541 caggcaaaca aaaaggagca ggctgattcc cgttgtcatg cggatggcgc gccattggag 3216601 gctggcaagc attttttttc tcatacgtac ttcacatcca catcaccgat aaataaggaa 3216661 acggacactt ttacccggcg ctttgactcg ctaaaatcag ttgacgcggc atataccttc 3216721 gtgcttaatc cgcttttctt cgagccgatc agattaatgt ctcctataaa aacagccgag 3216781 ctgacagcca cttcaaggtc cgatggtaca taaatatcaa cgttaccaat gactccgcta 3216841 atgacgattg tactttctcc ctcgggaatc atcgctttag ataaatcgat tttgatatca 3216901 ccgataaaac cagagacatt taaatcgttc aggtcaaacg gctgcttcat catttgcagc 3216961 tcaccgataa aaaagctgcg catgtcggga tgttttacat cttttggcgg ctcatgatgt 3217021 tcttttttat tgagattgac ctgtttctca ttcggttcaa atatcggctt ccctttgata 3217081 agcctgtagc cggcgtaaat cagaaatgcg gcaaacgcat agccgaataa attaaaggtg 3217141 atgctgaaga ggtttttcaa aaatagaaac gcggcaaaga tatacatgac ggagccaagc 3217201 caatcacggg aatatttttt aaggaaatag ccggcaatca gaaaaaagag cggccaaaac 3217261 agcagatcgc ctattccgat aatttgcaaa aacatactga tgccgaataa agcaatgatc 3217321 aatccgagaa gctgtttttt tgtcattcct ggtgtccgcc tcctttcttc tgcctagtgc 3217381 taccgtatcg ctagatcccc gctgtccgtt ttgatgtcga ttggatgccg gccgcttcct 3217441 tgcgtgcctg tgatgtgatg ctgttcttta tgtcctttat cagcaaatga atacggcgaa 3217501 ctgacgtcac cgcttgctga taaagcattg actgcaaagc tgccattttg gggaaggctt 3217561 acattagcat caccgcttgt cagcgtgaca gatacgggac cggttacctt tttcaataca 3217621 gcattaaaat ctcctgaagt cattttcaca tcaagagagc ctgatacatg aaccagattt 3217681 gcgtcccctg aagctaaatc aatgccggct gttttggaga cggtatttga aatggaaaca 3217741 tcccccgatg atgccttcac tttcagatct tgaatgcgga cgtccgtcac gctcgtattt 3217801 ccgctcgcag atactgcgtt cagcccggaa agcgcaagat ggtcattccc ggccacagac 3217861 acgtcaccgc ttgaggttcg tactgccaga tcacctttat aatcatacgg aagcctgacg 3217921 ataagagttg aacggttaaa tccattcaaa aattgaaatt ctttttcctt tacggtcagc 3217981 tccagttttc ttttgttttc agtaacaaat aactttcctg agtctcctga aatgcctgcc 3218041 gatatgtcac ttcgttcttc cgctataatc cggacatcct tgctatccga ctcaatgacc 3218101 atgctgtcaa tgtcccgcgg cgatgcgctg gctgaatcag cttctgtgcc atttatgaaa 3218161 cctaggcctg cagcaaacac atcttttacg acgacggcga aaaaaaccag aataccggca 3218221 gtgatcaaca gtttgccaag catttttttc attcggtttc atccttctca ttcattctat 3218281 tataaaggaa aagcttgcga attgatacgt gcggaaggga aggacttgac cgcaaatcct 3218341 tccccgttcc gcttattcat ttgccgcttt tgtctggtct gatttttgca gtgaaagtgt 3218401 ccgcattttt tcaatctccg cttccacatc gtctgcgaat tctttacgtg taagttctgt 3218461 gccggcttcc gctgactttg aataattcgc gcggatttcc atttcttcaa tacgattttc 3218521 aatacgtaaa aattcacgat acgcgctttc actgtcaatt ttgtcaaatg tcgtattcat 3218581 atgctcttta gctttcgccg catttgcccg cgcaatcagc gcctgttttt tatcctttac 3218641 gtcctgaagc tttgtttcaa gtgcagccag ctgctctttc agatcagcca gctgactgtt 3218701 tgcctgttca taggaagctt tatgctcagc cgccttccct tctaaatact tcatttcagt 3218761 cagcgccttt ttcgccagtt cttcttcacc tgcgtcaaat gcgagctgtg cctgattttt 3218821 ccgtttgcca gccacttcag cggcttcttc atattttttc ttaaattgat aggcaatcgt 3218881 gtgctgtttc acaattgttt gctttgcttt tgcgatgtcg ctttccatat cgcgtacata 3218941 ttgattcagc atcacctttg gattctccat tttatcaagt ccttcatgaa ctgacgcaac 3219001 aaacatgtct ctgattcttt ttaataccat acctgattcc tcctaatata ttgatattat 3219061 tttttcttca aaaattcttc ccattcgtca tcaaagtgag attggtaggc agcagaagcc 3219121 ggttcaggat caaaagatga tacaccgtta tcagctgatc cgtttttcat cagcttccag 3219181 ccgtaataca ccatagcggc cgccaatgcg attccgacga caaacggaag tgagcagatg 3219241 agcataatgg ctccgatacc gcccacgatg attcccgtga tggtttttcc cgcggcaaac 3219301 cttttgattc ctgcgtatgt catcaagctc ccgatggcga gcgggatgat aaagccgaag 3219361 cttcctcctc caaaaaagac ggagatccca aatacaatta ataagaatcc gcctattgtt 3219421 ttcttgttta ttttcatgca gatcctcctt tcgttttcct tgtcttcatc ttatacaagt 3219481 tggaagatat gcaaaacgaa tcagagattg atttttatat aagaccggag tcgtatctcg 3219541 caccggaccc attggcacaa aaaaacgcca tgcacgaggc atggcgtttt aaaacccttt 3219601 acagatgaac acttgcttcc ctttctttaa ttaggtcgga cctttctgct ttggccaatt 3219661 ttgtaaacag caagattccg atacccgcaa taatttcgac aatcccaccg acagcgatca 3219721 ctttacctga gccgaaagca ttagcggcat acccgcaaat gacagctccg gcagggatcg 3219781 aaatatttga gatcatatgt ataacggcgt aaacctgcgg ctgatcctca ctatccacag 3219841 acgtctggat aatcgtgtac tcaggaacat taacagcact gactgcggca ccaaaggtaa 3219901 aagcagcgaa aaagacgagc ggcaaaaagg tattcatccc ggtaataaag aaagcaaatc 3219961 cttcaataat gccggcagtg acgaataaca agccgtacct gtttaccttg actttcgcca 3220021 gcacaaaccc taataaaaac gcgcccgcgg cggtggtggc ctttaaaagc gagtatacga 3220081 tcggctggcc gtttaaatct tccgcaacgt atacggcaga gagcgcttcc catggggcag 3220141 ccgcgaaatt cataaagata cagtaaatgg cgagcggata taaaatctgg tgttttctga 3220201 cgagcctaaa gccgcgtttc agtcttccga tatatgtgcc tctctgtgta acaaccgcag 3220261 actctgattg agattcaacc gcagtgtact taataaaaag aacgagaaaa cctgacacca 3220321 aatagagcac aagtgcgata agcatggtat aagaaggact aataaatgta agaaaagcgc 3220381 cgcataatgt gacagcccca agccggacaa tttgagcgga ggattgcagc acagcgtttg 3220441 ctttttgaat gccctgttca ttgacgattt gaggaatcaa agcgatagag gcgggattgt 3220501 aggcagctcc agtagctgaa tgcacaatca taagcgtcat gacaaaccac agcggagaga 3220561 agcccgcaaa atgacataga gggataatca aaacaatcgc cgcccttgtc agatctgaaa 3220621 agtacatcca aaatttcagc gtggtctgtt tcataaaagg ccccgtcaca ggcgccagaa 3220681 cggcttccgg caaaaacgtg acagcaatca ataaagcagt gccgatcgca cctttgccgt 3220741 cataaattaa aaaccataat attgaattaa atgcgaacat atcgccggat atcttgacta 3220801 ttcttgagaa aaacagataa ttgaaatttc tcttccagat gctatcactt tcaattaaat 3220861 tcaccatcca tcagagcccc ccgttgccta ttttttacat ctatttatta caatatctca 3220921 tttttccatt tttcagtcaa taattcataa ggttcatttt ttgtcgtaaa atgggaaatt 3220981 gacagagtga aaaacaaaaa aagccggcat gtatttgaac acgccggctt tccttttcac 3221041 tttttatgat tcgctgctgt ttcggtcccg aaacacaatg gcacttcttt catattctac 3221101 atcgccaata ccgcttcttg cattcacaac ccgggcggcg gcaaagaaat aatcggacag 3221161 acgattgaga taacgcagca ctgtttcatg aatctcctcc gatttcatca gcgccaccac 3221221 tcttcgttct gcccgccttg taatggtgcg tgcgatatgg agaagcgaag cacactttga 3221281 tccgcctgga agaataaatt tcttcagttc cggcgcttct gctgtatagg catcaatgcg 3221341 cgtttctaaa aaggaaacag attcttccgt tagtttatag tcttttcttt ctgtgacgat 3221401 tgccagatcg cctccgcagt caaacagctc atgctggatg gtcagcagct cggctgtcag 3221461 atcttcaaag ccgggctgcc cggaaagctc tgccaaagca agcccgataa agctgttaag 3221521 ctcgtcaatc gtgccgtagc tttcgacgcg taggctgtcc ttgtccgttc tgcccccgac 3221581 taagcccgtt tgtcccttat cgcctgtttt tgtatatagt ttcataccct gaatctcctt 3221641 tacagactta ttcaaacaac tcagcagcct cttttataca ttcagctgtc cctttcttta 3221701 tcaattggtt cagccgctgt tctatgtttt ctgattgctg agtttgagtc gcggcgatga 3221761 gaatatcacc tgtgcctcct ccgtctccca gcactttcgt ccgttctgct tcggcagcca 3221821 taagagcttt gatgaagaat tgatctgccg catagccgtt aatcaaaatc caaatcgaaa 3221881 agccggtctg aacgcatatg aaaacggata actctccgtc ttcatatgtt cgatacacga 3221941 aacggtcaag tctttctgaa gaagccatcg cacacgtctc ctgcagttga aaaccgcttt 3222001 ctgaaagaca ggccgtaagt ccttctatcg gatctggctg atctggcagc cgtttatgga 3222061 tcagcgtcct gctccacgaa aaccctgcac cgataggcgt ggaggacaat gttcgaagcg 3222121 ggatttccgt ttgcagaaga atgtcatcac gccccgcttg gagcaatgct tcaaatggga 3222181 tagactgccg cttcacgcta tctttttcag gctgaatcac aatcatcggt ttaggtgagc 3222241 tttgatgaac caaggcggtg acatctgtat cgtacaccgc ctttatgctt tgttctgtaa 3222301 cagcatattc cggtttttgc ttaggcccgg cggtaccgtt tttcataaac atgagcccat 3222361 cacagtacag gcttgcggtg ttcagatcat gaaaaacgct gacagctgcc aatccgcttt 3222421 ctctcgtcag gcgtttgatc agatcaagca ggtctttttg ataagccaga tcgagaaaat 3222481 tagtcggctc gtccaaaaat aaaatacgcg gctgctgcgc caaagcttgt gccaaataca 3222541 cccgctgctg ttcccctccg cttagttcgc gaatcggctt ttgcgcaaaa tcggccactc 3222601 ctgtttgctc cattgcttcc tgtacaatgg cttcaccctt ttcagtctgc tgtctgaaca 3222661 gccccgtttg gaatggatat ctgccaaagg ctacagtttc ttcgacagta aaggtgaagg 3222721 cttgatccat tttttgcggc aggacagcca tgatttgcgc cagttccttc ggtttatagt 3222781 ccgccagcag ttttccggcc agataaaccc tgcctttctt ggccggcagc gtacctgtca 3222841 gcaagtgcaa aagcgtggtt tttccgcttc cattagggcc gagaattcca agaaattctc 3222901 ccttctccac tgttaagctg acattgttga ttaggcggct gtcgccgtat cctcccgaca 3222961 gcccttctgc cttcatcata agcttctccc cccgcgatgc tgccgaatta aaataagagc 3223021 gaacacaggc gctcccgcca aggacgtaat gatcccgatc ggcagttcaa tcggctcaat 3223081 gatggttctg gaaagcagat cggctaaaac aagaaaccct gccccaagca aggcggacaa 3223141 cggcagtaaa tgccgatggt ccgttcccca caaaagcctt gtgatatgcg gaatcacaag 3223201 gccgacaaag ccaatcgtac ccgatactgc cacagcgctt cccgtcaaaa gagatccggc 3223261 tattaaaatc atcatcttcc tctgctgaac gctgactcca agaagctttg ctttatcttc 3223321 tccatatgtc atcacgttca gttcccttcc gtttataatc aataaaatgg ttcccaaaag 3223381 aaaaaacggg agaaacaaaa taacatagct ccagcccctc attgagacgc tgccaagcag 3223441 ccaatgcaca atcggaagca ggttgtctcc tgtcaaggcg atgataagag aaataaatgc 3223501 gcctaaaaaa gagttggtga tgacaccggt caaaatgagg gtggaaacag acatcgaagc 3223561 atgaacgagg cggctgaaga aaaggaccgc cgccatcgtg gccagtgccg cggctacact 3223621 caaaaccggg agtgtaaacc ctccgatgac aggaaggtgc aaacctaaga acagagtcac 3223681 aacagctccg actgaagcac cggatgacac acctagcgta tagggatcag caagcggatt 3223741 tttcaacaat ccttgaaaag cggcccctgc aatagaaaga gccgccccca caagggcggc 3223801 cagcacaact ctcggcagtc tgatattcat cataatatta gtgtacatcg gatcatcaga 3223861 accgatagag ccgccgaaac cttgatgcca aaagacacga aaaacagcgg gaataggaat 3223921 atgcaggctg ccgcaagaaa ttcctaagat gatgctcacg gctaaaaatg agaaaccaat 3223981 gatatatgcg gcataacgat tattccttaa acgtatccgg gtaaatgctt tccgcaagtt 3224041 cttcgacccc ttcgatcaga cggggaccgg aacgtgtcac aagatcaggg tccacatcat 3224101 atacacgatg atgtttcaca gcattgattt cgctccagcc atcgcgtttt tccacagctt 3224161 tcgctttcac accgtccgtt gtaacaattg catcaggatt gagttttacg atcgcctcgt 3224221 ctgtcatttg cacccatcct gtctgatccg cagctgcgtt tttagcatgg atgacattta 3224281 gcatttcatt cataaacgta tcttttccgg ttgtataaat gtcaggatca ggagaaacct 3224341 cgataaatac gcttttctcc tcgtcttttg aaatggtttt cgctttttct tgaatatcct 3224401 ttagatctga tttcatgctt ttcacgagct gatcggcttt tttctccgcc ccgccagctt 3224461 ctccgatcat ttcgattgat ttgtacacct cggagaatga ttgtgcatca ttgacagtca 3224521 gcactgtaat gcccgcgtcc ttcagctgtt tgatggcatc cgctgatgct gacatggaag 3224581 actcatgggc cagaacgaga tctggtttta gagaaatgac tttttcaacg tttacattca 3224641 tatctccgac tttctcaacc tttttgactt cctttggata ggtatcgttt gtggtgacac 3224701 cgaccacttt gtcaccaagg ccgagtgcgt atgtaatttc tgtgttgctc ggcattaatg 3224761 aaacaatctt ttttggctct tttttgatgg ttacatcttg gtttgacgca tcatcaatgg 3224821 tgacagggaa cacttctgtt ttttgttttg cctttgaatc cttctgatcc gcaggattgc 3224881 cgcagcctgc cagcataaca gcagccaaca gaagcgcagc ccatatcccg gctcgttttt 3224941 tcataatctt ttcctcctaa acgaactaaa aaagcatctc tacgacggta aagatgctgt 3225001 aaacaacaca aaaaagccta ttgtttacac atcatctgtc ctcgcagaat tcgtgctgat 3225061 caaacaggca ggtatcctgg ctcttggcgc ttggccaatt acagtggcgg gaccgcaccg 3225121 gcttttaccg gtttcccttt taagccggct gttgttcacg gaccggcacc tatttgacat 3225181 tcgtatccgt ttttcggagt aattatacta tatgactgac aggcttgtat atgtgtcctg 3225241 aatgactttt ccccatattg tgtatggaag caaaatcctc gtaaacacta aatttgatct 3225301 tgtatactta ataccatcat ctatcaaaag gaatgattct tatggattta cagctaaaag 3225361 aaaaactcgt cttaatcacc ggctcgacgt ccggtatcgg gaaagccgcc gcaaaaagct 3225421 ttctgcaaga gggtgcggca gtcattgtca acggacgcaa acaggagact gtcgatcgca 3225481 ccattgaaga gctttctggc tatggaacag tgcacggtgc tgctgccgat ttgtcaaaaa 3225541 cagatgaagc agcggctttt atcgaaaaag taaatgaaat cggtgatatc gatatccttg 3225601 tcaacaacct tggtttcttc gaggtaaaag acttcgccga tgtgacagat gaagagtgga 3225661 atcaatattt cgaagtgaac gtgatgagcg ccgttcggac aagccgtcac ttccttccaa 3225721 aaatgcttgc caaaaacagc ggccgcattt taaatattgc aagtgaagca ggcgtcaaac 3225781 cgctgccaac gatgattcca tactcaatga caaaaacggc actgatcagc ctttcaagag 3225841 gaatggctga aatgacaaaa ggcacaaatg tgacggtcaa ctcagtgctc ccgggaccta 3225901 cttggacaga gggcgtggcc tcctatatgg aaggcgccgc acaagcagcc ggacaggata 3225961 cagatacatt tatcaaagac tatttcaagg tcaatgagcc aacctcactt attcagcgat 3226021 acgcgacagc agaagaagtc gccaacacaa tcgtattcct cgcgtctgac gccgcatccg 3226081 ccattaacgg cacggcacag cgtgtggaag gcggcattat ccgttctctg tagtataaaa 3226141 aaacgcatcc gtgtttcgga tgcgtttttt ttatacgtct ccagcaaatg gtaccggctg 3226201 atatccgcct gtttccagtt gtgctgaaaa caaccctcca gcgtgaggct gctcgtatct 3226261 ctctttttct gtcatttgtt ctgttgccgt tgtaatgtaa agggttttta agtctctgcc 3226321 gccgaacgcg cagcacgtga catatttagc cggcacgctg attgaattga tttctttttt 3226381 ctgaaacggg tcaatgtgaa caacgcggct gccgccaaac agcgccaccc acagcatgcc 3226441 attttggtca attgtcatgc cgtccggcaa tccgtctgac tgatcaaaac gatagacagg 3226501 ttctggattc gaaacatctc cgctttgagg atcatagctg taacgtacaa tctcctgggt 3226561 cggcgtgtcg atgtaataca tcaaattccg ctcgcggtcc caatccaaac cgtttgaggt 3226621 ggagacttga tccttgattt tgacaagact gccgtctaga ttcaaacggt acagcgacgc 3226681 ctgtttttgc tcgccttcca tgctcgtcgt ccccgcccaa agccttccgt acgggtcaca 3226741 tttagcatca ttaaatctca ggctctcatg catgtccttc ggctgtttaa ttttttccaa 3226801 gctgtcatcc cgaagatgat acaggtaaaa cccgtccttc atcgtcataa tcagttcatc 3226861 ctttgaatat ttcgcaagcg ccgtcacaaa ggatttgaat ttgattgatc ggttgatttt 3226921 ttcttcaggg tcaaagatgt ggagctcgct ccccaggata tcaacccaat ataagcggcc 3226981 gttctcttca tcccataacg ggccttcacc aatcactgcc cgagtgtctg cttccaatac 3227041 tgcatccatg tgttacacct ctttagcttc agtctatata ttgttattcc cggcaaagag 3227101 gtgtccaaac cacttgatgt ttattgtttt ttaaaaagga tggtaatgac cgttccaatg 3227161 ttcgttctgc tgttcacatg gatcgttccg ttatgcagat ggacaagctc cttggcaatc 3227221 gcgagcccga gacccgttcc ggcagttgaa tcttttgtgt tcgtccctct gtagtagcgg 3227281 ttaaacaaat gggtgatcgt ttcttcatcc attcctttcc cattgtcctt cacttttaaa 3227341 gaaatatgat tttttgtttg ctccagaatg acttgaatct ctgttccttt gccgttgtgc 3227401 ttcacggcat tcccaaggag gttttctaat atgcgcctga accacgcttc atcaagggca 3227461 aattcaatat gctcttcttt ggatacaaac gagatatcat agccttcaga aaacggattt 3227521 ttcttaaaat cctcaatgac atttttaaaa aacgggataa ggctagtgag ctttctctca 3227581 ataggaagag catcattttt caggcgatac gttaaattta agtcttcaat cagcttagac 3227641 atgtattcag atttttctct gacaacctgc cccatttctt tcacttcttc cggcgaccag 3227701 tcatactgct tcgactcgag catcatgctg tagccgtaaa tgctgctgag cggtgttttt 3227761 aagtcatgtg acaaaccggc aatccattct tcccttgtcg cctggatttt ttctctgttt 3227821 cttttatccc ttctcagcgt ttcagtcagc tgatccattg attcaaatat ctcaccgaag 3227881 aagcggtacg gctgtttgat ttttcccttt ttatttttgc tgacaggacg gccttcccgg 3227941 tttctgggct cctcaagctt cccttttgac agattgacca gccatctaat cgtgtgaaaa 3228001 atcggcagcc cgaatcggaa catataccaa acggtcatcc aaatgatata catgaacaaa 3228061 acggccatca cgagaaacat cgcttttaat acaaccttca ggaatgattt gttaaactcc 3228121 tgatcggtta catagactgg gttcggcacc gtagcgacca tccatctgtc tttattgagg 3228181 atcttaacgg aaatttcccg cttatagttc caaggcttag agctgtattt aagcagctcc 3228241 agctggttca tcgtttttct ctcgcttttt gtgctgttga tgctgtcgag aatctttcca 3228301 ttgctgtcta acaggtaaat ggcgcctttt ttccgtttaa tatagtcgat ggtactagac 3228361 ttatagtgcg ctagtgagtc tatcttttgt tcacgctttt caacggaagt caggagctgt 3228421 tcactttttg atttccagcc ggacaataga agatacgact tatcttcaat attgatggcc 3228481 caataattca gtttatagtt atgaagcttt ttggttttat aaatagacaa aagctctttc 3228541 ttggtatagg tgcccggcac gtcttttggc acgccgtagg aataatcagt gtttccttcc 3228601 gaatcaatga tttgcatcca gccgtgctgt ttatcaacag atttcttcag gaaattatcc 3228661 acttcccatg tcccgtcttc gtttacatcg agatatgcct caagtgtgtc ggtcgttgct 3228721 ttcgtcagcc ctgaattgga ttccgcatcg ctaaaacggg cgtctaaata gaaaaacgat 3228781 gcaacaagca taaccgtaag cagcaggatc acaatcagca tctggccgaa aaagtgaaac 3228841 aaaaacttcc atcttaacct catgaccgct tgccttcagg atttgggata aaacgatagc 3228901 cgagacctcg aacggttaca atatactccg gattgctcgg atcgcgctca atcttctccc 3228961 taagcttgcg aatatgaacc atgacggtgt tgttgtcacc gtaggaagga tagccccata 3229021 ctttttcata tatttgatct ttggaaagca ccacgttagg gtgttcacaa aaatactgca 3229081 aaagctgcag aagctgggct gaacaggcaa cggcttcccc gcctacgatc aactcggcat 3229141 tttgcggaga aaaagtaaag taatcatatg tgtaggtttg atttgaactc gtttctttcg 3229201 attgatatgt acgcttgaga tgcgctctga tccgcgccgc taattccagc ggattaaatg 3229261 gttttgtgat atagtcatca gctccaaccg caaagcccga taatttgtcc gcgtcggatg 3229321 atcttgccgt caggaaaaaa atcggagcgt ctgaatactc tctgatcaat gtgcaggctt 3229381 caaaaccgga cattccgccc atcatgacat ccagcacaat caagtcaacc ttattggcct 3229441 tcacaacggg aatcgcttct tctgcgcttg ccgcatccag tatatttcga taaccttctt 3229501 tttcgagaac gcgtttgatc atgtccacaa tcgctttctc atcgtctacg attaaaattg 3229561 acgcattttc cacttttatg ttcctttctg tcactgtttt tttcatctta tcattatatc 3229621 gtttatttat ggtacatttt tgaatacatt ggagccttgg caaatcaaaa cagcaaaaaa 3229681 ggagcaaaca agcgctccct tttgatgttt tttcatatga aaatattatg agttctcatc 3229741 taccatgtac aaaataaact cccaaaaccc cggtacatcc tgacataaaa gcatatcagc 3229801 cttttcaaac attttgatct tcagctcttg ctctaaatct tctctttctt gataggacgt 3229861 attgctgagt ttttttctga tcatcggtga aaagcatgca atcaggtgct caatgtcata 3229921 agtctcgtct ttttgtttct ttttttgttc aaactggccg tccacagctt acttttcccc 3229981 ctttttttgc gccgctaact gctttctgat attctccagc ccctttttat gaatgttgga 3230041 gatgttttgt cgggactccc ctaatgaatc tgcaatctcc tgcatcgtgg caccgtgaag 3230101 atagactttc gtcagcacac ttttttgttt gtcagtcagc ttctggatcg cttggtagag 3230161 ctggtaatcc tgtacatgct ggctcaaatc atcctgcctg tctaaaaatt cttcaaatgc 3230221 atcgctacct gtttcggaag aaagccgatc tcccgcctcc ggatgatcaa ccgtcagtgg 3230281 ataccgtttt tggtttttgc gaacccgctt atcaaaatca atagaaaaga tgcgaatcat 3230341 tgaattcata tacttgacga tgcggatttc tttataaaat tgcttaaata gctcgtccaa 3230401 tgatcttgca tctttttcgt tagggctttc cattacgttt ttgaacaaac ggtaatgctg 3230461 aggattgctc aaaaaatgct tcacgatggg atgcttcatt atctccttac attttgaccg 3230521 taaaagactt tgatagtcca tcaaaccgcc tccctactaa attaaatgaa ggaaagcaaa 3230581 aaaaagtaaa ctactacttt ccgcctagtg tcttccaaaa tactttgcag cagtttacgt 3230641 tttatcggtt ttcctcactt acatacatga ctgcagaaaa agaagggagg tattttccta 3230701 tggatcaggt ttttatagag gaagtcgtaa aacagatcgg caatttgggg tttcccgcgc 3230761 tgattgcaat gtatctgctg acccgattcg aaaagaagtt tgatcaacta atagaactaa 3230821 tgacagaact gaaagatcat gcaaaaaaat aatttttcaa tcgaagttga cttttcactg 3230881 gtttttttca cttaacaaaa cagaagggaa aacgaaaggc ctttcacctt ctctttctgc 3230941 tatcacattt aaatgtaagg aggaaacatt tcatgaaaaa acaaaatgac attccgcagc 3231001 caattagagg agacaaagga gcaacggtaa aaatcccgcg caatattgaa agagaccggc 3231061 aaaaccctga tatgctcgtt ccgcctgaaa ccgatcatgg caccgtcagc aatatgaagt 3231121 tttcattctc tgatactcat aaccgattag aaaaaggcgg atatgcccgg gaagtgacag 3231181 tacgtgaatt gccgatttca gaaaaccttg catccgtaaa tatgcggctg aagccaggcg 3231241 cgattcgcga gcttcactgg cataaagaag ctgaatgggc ttatatgatt tacggaagtg 3231301 caagagtcac aattgtagat gaaaaagggc gcagctttat tgacgatgta ggtgaaggag 3231361 acctttggta cttcccgtca ggcctgccgc actccatcca agcgctggag gagggagctg 3231421 agttcctgct cgtgtttgac gatggatcat tctctgaaaa cagcacgttc cagctgacag 3231481 attggctggc ccacactcca aaagaagtca ttgctgcgaa cttcggcgtg acaaaagaag 3231541 agatttccaa tttgcctggc aaagaaaaat atatatttga aaaccaactt cctggcagtt 3231601 taaaagatga tattgtggaa gggccgaatg gcgaagtgcc ttatccattt acttaccgcc 3231661 ttcttgaaca agagccgatc gaatctgagg gaggaaaagt atacattgca gattcgacaa 3231721 acttcaaagt gtctaaaacc atcgcatcag cgctcgtaac agtagaaccc ggcgccatga 3231781 gagaactgca ctggcacccg aatacccacg aatggcaata ctacatctcc ggtaaagcta 3231841 gaatgaccgt ttttgcatct gacggccatg ccagaacgtt taattaccaa gccggtgatg 3231901 tcggatatgt accatttgca atgggtcatt acgttgaaaa catcggggat gaaccgcttg 3231961 tctttttaga aatcttcaaa gacgaccatt atgctgatgt atctttaaac caatggcttg 3232021 ccatgcttcc tgaaacattt gttcaagcgc accttgactt gggcaaagac tttactgatg 3232081 tgctttcaaa agaaaagcac ccagtagtga aaaagaaatg cagtaaataa aagacttgcg 3232141 gcttgcagag agcactcgtt ctctgcaagc cttcataagg agctgaacca gtgaaacatc 3232201 aaaacccttc aaaacgctta ttgcggctct ccataaagta cttgctggcc gcagcagcag 3232261 tggtgttgac ctattttgct gtcatctata tattgttttc tttagcggga acgagctacc 3232321 gctcagcagc tcatgtcctg ctttttgccg tggtattcct tgttctcgga ttatgctttg 3232381 aaccatttga acggctgatg atacatagct ttacattttt caagacagga aaacgtctat 3232441 tcattctcct tgctggcatc gtacagctgc tgtttttgtg gatgactgct catacaacag 3232501 accaattgat cagcgacatc tggctgtcca ccacagaaga aatgattgtc gcagccgttt 3232561 ttttgatttt agacaaatgc aactcggctc ttcccagcta aaaaaagaac gcattccaat 3232621 tggatgcgtt ctttttattc atagcgaagc gcgtctacag gctgaagctt cgaagccttg 3232681 atagacggaa gcaagccgaa gataatgccg actgccattg aaaagatgag tgctccgaca 3232741 acagctggaa tggagacgat aaaaggcatc ggaaaaatga ccgtcagcag cttggcgatg 3232801 ccgaagcccg ccagcacacc gagtattccg ccaatgcttg tcagcacgac agcctcggtt 3232861 aaaaattgaa ataaaatcac acgccgctta gcaccgagcg ctttcttaat tccgatttcc 3232921 ctcgtgcgct ccgttacgga aacgagcata atgttcatga cgccgatacc gcccaccaaa 3232981 agtgaaatac tggcgatacc gccaagcagc aatgcaaatg actgattaaa ggactccact 3233041 tcctgcgcga tctcctgaag atccattaca ctgtactctg ctttttccag ctcagcttct 3233101 gacagtccct gatttaaaag atctgcagcc attacacccg cttcttggat atgctcagaa 3233161 gaatcagcct gcacggcaat ctgcgttggc gcgtcaaatc cttcaataag cggccacact 3233221 tttttcggca cgtacaaaac cgggttcgca tagtcgcctt caaacatgct ttcctgttga 3233281 tttttttctt taaaaacacc cacgacctta aacggcacac cattcatctc aatgctttta 3233341 tgcagagctt ctccgtctgg aaacagttca tctctgacag cttcattgat catcactact 3233401 tggtgtgtgc tgtttaaatc gttttccgtc agctttctcc cttcggttat tcggattgga 3233461 aacatgtcga agtaatcatc gtccactcca tacacttggg gatacgaaac gttagttaaa 3233521 tgaaaaacgc tcgcgccttc tgacaagtaa tataaggata atcctttgac catcggatct 3233581 gatttgatcg cctttactgt ttcttccgct acaggcggcg cggacgcata cgacacctga 3233641 gggccgccgc tctcctcttc tccgccagac ggctggtaga caacattgat ggcgttgttt 3233701 cccatgccga tcatactttg ctttaactgc tcactttggc ccttcagcat tgaaacaatc 3233761 gcgatgattg ccgctatgcc gataatgacg ccaagcattg tcagaatcga tcttaattta 3233821 tgagagaaaa tggattgaaa ggagattcga atatgttcaa gcatggctga tatcccctct 3233881 ctcatctaat accaactctc cgtctctgat aaaaacggtt ctgtcagctt ttttggcgac 3233941 gtccgggtcg tgggttatca taataatggt cttgccttcc cgatgcagtt cagaaaacag 3234001 tgccaaaatt tgttcacttg atttggtatc aagcgccccg gtcggttcat cagctaaaat 3234061 aaacctcggc tgattgacaa gggccctcgc tatcgccacc cgctgctttt ggccgccgga 3234121 cagcttaggc ggtttgtagg agaccctgtc ttttaatccg actttttcca gcgcttcata 3234181 tgcccgttgc cttctctctt ttttcttcac tttattgtag atcatcggca gctcgacatt 3234241 ttgcagcgcg gtgagacgcg gcagcaaatg aaaagtttga aacacaaacc cgattgattc 3234301 attgcgaatt tcggctaaag ccccgtcttt ccctttcaat atatcgatct ggtcaagcgt 3234361 ataggttcct gaggttggcc tgtccaaaca gccgataata ttcattaacg ttgactttcc 3234421 agaaccggaa ggccccataa tagctaaaaa ctcccccgcc tgaacggtca gattgatatg 3234481 tttcaagatt ggaacttctt cttttcccag cttgtacgac ttcgaaatat tattcagtgt 3234541 cagcattgac tgtaacctgc tttccttcct tgaccgcggg atcaggatag atcacataat 3234601 cttccggcgt caggccgctc ttaatttcca ccatgtcatt ttcatcagtc tctccgattt 3234661 caacaggctg cttaaccgct ttgtgattct catcagcttt ccatacgtac ggttcgccgt 3234721 catcctgaat gaccatgtcg gacggcagct tgatcgtgtc cgcatcagca ttatcactca 3234781 tcacttcgat gttgacatga tagccgactt caagaccttt atggctgtct aataaaatgg 3234841 tgaaaggata gttagaggac tggggattca tttcttcatc agcaaagctt tctgattctt 3234901 caccctcgcc tgctcccgct ggaagcttgc cgatcgaggt gacctttcct ttccactcgc 3234961 cctcaccgcc tgttttcagc gtgaccctga ctttgctgcc ttttttgatc gtgtccatta 3235021 acagctcatt gatttggctt ttgaccagat atttgcctgt cgaaacaatc tggatatacg 3235081 ggcctgctgc ctggtcgcct gttgcaccgt cagcgatatc ctgattgacg ctttgaacga 3235141 ttccgtcatg cttgcttgta atgacattgg aacctttgtt tttcgtcagg ccagccagtt 3235201 ctttttgatg ctgcttcagt tcaagctggc ttgttttcaa atcgaaattg gtttgatcaa 3235261 gttcatcttg aagctggttt ttctcttctt ttcctgcaac tttcagcttt ttttccgttt 3235321 ccgttattga tttttgcaaa cggttgattt gcagatttgt catttcaatt tgcaaattgg 3235381 cttgctccac ttcatcagaa tgatcctcgc cctcatactc aaaaagctta tcgccctttt 3235441 taacctgatc gccttctttg acgtatgttt ttttaatgct gcctttttct gaatctatgt 3235501 atactttctg ctgtttctca ggttcaacct ttccagaaaa cgtttggcct gattctgaat 3235561 ctcctcccat gtataccgcg accgattcag catagggctc cgatgatacg gcaacttggt 3235621 tcatgtgagt aaaaaagtaa aaaccgccag cgccgatccc agccaataca agcacaccgg 3235681 cacatatcgc accgccaata agccattttt tcttcttgga cacaacgatc tcctctttct 3235741 gtaaactatg taatattttc gaaacattct aaccaatatt atctattaat tcaaaaagac 3235801 ttgcaatcct tttattgaaa tgacggaatc aaatagaaaa attgtatttt caaagccgaa 3235861 taaaaaaaat cccggcttca aaccgggatt ttttcataca gtaactagct ctttttcatt 3235921 tttaatcaag tcatatgtca agcatacagg tttatttgta cggggatcag tcacgatttc 3235981 ggcatcaatc tgaaatacct gcttcaaaat gtctggtgtc atgacctcca gagcagttcc 3236041 ttccttgatg accgtgcctt ttttgagcgc gatcatataa tgagaaaaac gagctgcatg 3236101 gttaagatca tgaatgacca ttaaaatcgt ccgcccttgc tctttgttga gtctgtcaag 3236161 cagctgcaga atttcaagct gatgtgcaag atcaagatac gttgtaggtt catccagcag 3236221 aagcagttcc gtcccttgcg caagcgccat ggcaatccac acacgttgac gctgtccgcc 3236281 tgacaatgcc tcaatcggcc gttcagcata ttcagccatg cctgtttctt caagcgccca 3236341 tttgataatc cggcggtctt cgtcatttaa tctgccgaat cctgattgat gcggaaacct 3236401 gccgtacgac accaattcgt gcactgttag gccgctcggc gcttcaggtg tctgtggaag 3236461 aatcgccata tcttttgcaa tgtcctttgt agacatttta tgaatcgctt tgccgtttaa 3236521 atagacggca cctgcatgtg aacgcataat tctggacatt gtttttaaaa tcgttgattt 3236581 cccgcagccg ttcgggccaa ttaaggtggt aattttccct ttaggaatcg atatatttaa 3236641 atcctctaca atcaccctgt cgccataacc gattccaagc tgttccgttg ataatgaatt 3236701 catattcggc cccctcctct aattcgcttt catcaataaa taaataaagt aaggcgcacc 3236761 tagcacggaa atgacaagtc cgaccggaat ttctgatggt gccaatacat ttctcgccag 3236821 cgtatcagca agcaaaaaca ggaatgagcc gatgaaggcg gagaccggta tcagcgtctg 3236881 gtgacgtgga ccggtcagcc ttctagccac atgcggcgcg atcaatccga gaaacgcaat 3236941 gccccccgca gctgccacgc atgaagcggc aagagtgacc gctgccagaa gaagaatccg 3237001 tctttccttt tcaacagcgg tgcccagccc ggtcgccaat tggtctccga gctgcataat 3237061 gttcaaatag cgtgccttat ataaagtaaa cagaagcaag atcacaatcc aagggagaat 3237121 cgcccagatc atattccagt tcgcccccca tattgagccg gatatccaaa ccgcggcttg 3237181 cataaaatca tgagggtcca tcttgagctg aaaaatcagc aacagggcgt tgaatccggc 3237241 attcacccct atgccgacta aaatcagccg aatcggtgtc acgccttttt tccatgccag 3237301 aatataaatg agaaacgcag cgaggattgc tcctgccaaa gcactgaacg gcagcataaa 3237361 tgttccgaaa aagctaagat ctgaagctga cccttgaaaa aagtatataa aaagcactac 3237421 agcaagtgaa ccgccggcgt taattccgag aataccaggc tcggcaagtt cattttgaga 3237481 cacgctttgc aaaatggctc cagctacgga gatccctgct ccaacaagca aagaaaggat 3237541 gatccggggc agcctgaact caaataagac aagttcatca cgcgccgttc cttggccgaa 3237601 aaagacctga agcgttttaa gcggtgcaat tttgataacg cccaaattga gactgataaa 3237661 aaagaccacc acgataagca aaaaggtcac agccattaca atgagcggtt tgtttgtttt 3237721 tgttttcatt acagccctct cctttcacga cgtgccaaat aaaagaaaaa gggaacgccg 3237781 ataagagaag tcagcgcgcc gacaggcgtt tcaaagggcg catttacgag tctggccgct 3237841 atgtcagcaa aaacaagcaa aacagcaccg agcaccgccg agcaaggaat gatccaccga 3237901 taatccacac cgaccaaaaa acgggtaata tgcggaatga tcagcccgat aaatgcaatg 3237961 gtgccggcaa tggaaaccgc agctccggtc agaattacta caataagcat gccaaccagt 3238021 ttcaccgctg atgtatattg tccaagccct tttgccagat cgtcaccgag acttaacact 3238081 gtaacagacc gggcgatgaa aaacgcgagc gttaaaccga cagcccctgc aataagcaaa 3238141 agctggaccc ccgaccattt cacacccgct accccgcctg cgtaccaaaa gctgatatcc 3238201 tgagcgacat caaagcggat tgcaatggca gttgaaatgc cggtaaagaa ataagtaact 3238261 gccgtacccg ccagagcaag ctttacaggc gtaagtccgc cccttgaaaa catgcctatg 3238321 cccattaccg tcgatgcccc cagccccgct cccgcaaagg accatagcac aagccccatt 3238381 gcagaaagtc cgggaaaaaa ggcaaacgca atcgaaaccg caaacgcaga gcctgatgtc 3238441 acacccataa tcgaaggctc tgccaaaggg tttctcgtca tcccctgcat gattgctccc 3238501 gacactgcca acaatgcgcc tacaagcgcg gcagccgccg ttctcggaag ccgaagatca 3238561 tgtataattt ggtgagatgt ctttgtcggc tgataatgaa aaatggcctc ccatacagtg 3238621 cgcaaatgaa tatccgctgc acctagggat atggataaaa atgcgccaag gcaaagcagg 3238681 catagacctg cgataaggac gatgaccgcg ccatatgtcc ttgacgtcca ttggatttct 3238741 tctgatgcag tccgtatatt tttatgttga ctcaactgcc gtacttcctt tctgttactg 3238801 ataatgatta tcaattgctg tttcagtata tcactttttt cagctgattt aatagagtgt 3238861 tttgaacaaa aatgaaaatg catttgcaaa aatatcgtgt caaccggcac ttgcagtggt 3238921 ataatcacag atgataatga ttctcttttt catctatctt ttagaaagaa ggtatgagat 3238981 atgacccata tatacaagaa actcggagcc gcgttttttg ccctgttatt gattgcagcg 3239041 ctggcagcct gcgggaataa ctcagaaagc aaaggttctg cctctgattc aaaaggcgca 3239101 gaaaccttta catacaaggc tgaaaacgga aatgtaaaaa tcccgaagca tcctaaacgg 3239161 gtggttgtca tggcagacgg ctattacggc tacttcaaaa cactcggcat caacgttgta 3239221 ggtgcgcctg agaatgtatt taaaaaccct tactacaaag gaaaaaccaa cggcgtcgaa 3239281 aacatcggag acggcacttc ggttgaaaag gtcattgatt tgaaccctga cctgattatc 3239341 gtctggacaa cacagggcgc tgatattaaa aagcttgaaa aaattgcgcc gactgtcgca 3239401 gtaaaatacg ataagctcga caacatcgaa cagctgaaag aatttgcaaa aatgacggga 3239461 actgaagata aagctgaaaa atggctggcc aagtgggata aaaaagttgc ggccgctaaa 3239521 acaaaaatca aaaaagcggt cggtgacaaa accatttcca ttatgcaaac gaacggaaaa 3239581 gacatttacg tatttggtaa agactttgga agaggcggaa gcatcattta caaagacctc 3239641 ggcctgcagg ctacaaagct gacaaaagaa aaagccattg accaggggcc aggttataca 3239701 agtatttcat tagagaagct ccctgacttc gccggagatt acattttcgc gggcccatgg 3239761 caatcaggcg gtgatgatgg cggcgttttt gaaagctcca tttggaagaa cctgaatgcc 3239821 gttaaaaatg gccatgtata caagatggat ccgatcggat tctatttcac agacccgatt 3239881 tcattagaag gacaactgga gtttattacg gaaagcttga ctaaataaac aaaagagccg 3239941 cctgcccgcg gctcttttgc ttatttataa ggaacggctc aatttgaatc atatcggata 3240001 ttttctttga gccattcata ttaagctgca tcctcatcac gatcagtttt tttatgctgg 3240061 agagactgaa aaacgttttt tgcatattta acgaacggat tcctaacagg agaaattgtg 3240121 attttataaa aaagacacct gagcaaatca ggtgtctttt cattatgctt gtttttcttt 3240181 ctggaacttg ttactcacaa atggataaac gattaagccg acaaagaata aaccgatgcc 3240241 gagtataaat gtcgttaaat ctgctgtgcc tgttacgata acaaacacgg agtatgcaca 3240301 cgccagtatc gcgatcaatc cgtctcttac acgggagcct ttcagctggt catacgtttc 3240361 acctttgatg actaccttca agctgtagat tgcagatacc agatacggaa ttaaatatgc 3240421 gagtgtagcc gctgtcgtta aaaatgtaaa tgcgtcactt attgtccggg aaataaccga 3240481 gaaaatgaag acctgtgaca tgacgtttgt aataatgagt gcaatgaccg gacttccctt 3240541 tttattcgtt tttgcaaaaa atgccgggaa atctcctgct ttagcggctt ggtatggcac 3240601 ctcagagcca agcaaaatcc agccgagcat cgttccgaat aaacaaagga tagccaaaag 3240661 cgccataatc acgcttcccg cgtttccaac aatcgcatag agtacatcaa caaatggttt 3240721 ttcagagccg acaagcttat catgcggcag aacacccatc gtaattaaag tcacaataat 3240781 atatatgctc aaggcaatca gcaagccggt aattgtcgca cgtttcacat cacgctgaga 3240841 gcgcgcacgg ccggacagga tcaccgcgga ttcaattccg acaaacgccc acagtgtaga 3240901 aatcgcagcg ttatgaacct ggccaccaat tccaatgctt gtgccgtttt ctccttgaac 3240961 cgggaaataa aaatgaccga ataatgacgt ttgaaacaca aacaaaccgg caacgataaa 3241021 gaagacaaaa cctaatactt tagaaagcgt tgtgacaaag tttaatttac ttgcgccgtt 3241081 aatgctggca acaagaatcg cgtgcgttcc ccataacaag atcgtacata cggcaaacgt 3241141 cagtaattgg ccgagtgtca cctcttgccc gccgatcgaa aacatctcac gtttatcaac 3241201 caagatcggg aagaacgaag tcaagtaacc ggcgagactt gtgatgatcg ccacgttact 3241261 gatccagctc gccacccagt agccccacac cattgtgaaa ccggcagcgt tgcctttttt 3241321 cgggtcagaa aacagcgctc ttgcataact ttgcggtccc gctgtcagtt caggcttgcg 3241381 aatggacaag tgtccgaaca caagtgcaat catcagcacg ccggcacctg tcaaaagcca 3241441 ggcggacgta gctccaaacg gactcgcaat tgaagcaagc gagctcggca aggagaaaat 3241501 tcctgatcca accatatttc caacgacaaa cgccgttaat aaccaaaaac cccatttttt 3241561 tgtctgttcc attccagtac ctccatgatt ctttgtacgg accagacccc gagatcatat 3241621 aaacgcaaaa aaagcctgaa caaaagtcca tgcttaaaga aacacacacc cttgatctcc 3241681 ggatagccct ccgcgaaaaa gcacgcggca gtcctgcact tattcagata cagtcccagc 3241741 atagagaagg atcggctttc tccacacttc ggcgctgatg ccttttacac atgtttaaca 3241801 gcccctgtca gcctagcatg tgtgactcat catccgcgca acctctacct cactgagaaa 3241861 gagtgaggat ttaattattc agttactccc agaaggttat caaagaaagg atgatctgtc 3241921 aaagggaaca gatggaaaat acggatagag ccaagcccta tccgcatgtg gttatcgatt 3241981 atttttcttt ttttgcacag cttcttgaag cggatcatct tttagagctg aaccagcatc 3242041 ttcaagagct ccttggatta cgtttttttc tttttcggaa cgttttcctt tatctttatt 3242101 aaagaaaccc attcgtatca cctcttttaa aaaataggta catgtttaag atgccttttt 3242161 cctgaaaaat tatgcgggat attttttatc gtccaaagtc ctgttgatca aacatacatt 3242221 ctcttgatat atttgtaatt cagagatttt ttgcaaaaga taaaaggaga agcggcaaat 3242281 gacaggaaaa acacacatca tgggaggcat cgcttcttgt acggcagcgg cttattatta 3242341 tggatttgat ccagtgctta tggctgcgtc aggcgcggtt ggagcattaa tacccgatat 3242401 ctgccacaca caaagcaaaa tcgggagaaa atttcctatt ttatcgaaag tggtcagctc 3242461 cgtttttggc catcgcacct ttacacacag cctgctgttt atgctcatca tgttttttat 3242521 cacttctaca tacattccag ataaaaacat atcagccggc ctgatgatcg gaatggcgag 3242581 ccacttgatt cttgacgctt ggacggtgaa cggaatcaaa ttattattcc cttccacgat 3242641 ccgcgttcgg cttccattat atatgaagac aggcagtttt tctgagcagc tcgtgctagc 3242701 cggcctgacc cttgcttcat gttactactt ttatatgctg tttcatggcc gcatgtttta 3242761 aacatgagtg ctgagacttg tctgaaccgg ctgtttttag taggttttac ttaagaagca 3242821 tttcatgcag atgatcaaga aaacgtgagg agtcatattg atgaaaggaa ccttttttca 3242881 caatcagcgg tttttatgtt tttcgatctt atttatgtgg atcaaaacgt atgtgatata 3242941 taaactcggc tttgatttgc aaatcgatac tctgttggag gagctaatgc tgctggtcaa 3243001 cccgctcagc tttattcttc ctttattcgg gatcggcctg tttctaaaag aaaacaagca 3243061 gcgggccttt ttgctgattg ccaatttggt tctgactgtt atcttgatct ctaatacgat 3243121 tttttacggc ttttatatcg attttattac catcccggtt ttatttcagg ccagcaacat 3243181 gagcgatatg ggcagcagtg taaaagaact gttccatcct ctgtttatcg ccctgtttgt 3243241 ggatttggtt tttctgctgt tgttcgccag aaaaaccaaa cacccacaga caaaagccgc 3243301 tccccacacg atcaaacggt actatgcagc ttcctgcgga atgcttttat gcacactggc 3243361 acttgcagaa gtacagcagc cgaagctttt ggcacattct tttgaccggg aaatgctagt 3243421 caaaagcatc ggcctgtttc agttccatat ttacgataca atttctcaga ctgttaatat 3243481 cagcgcgaaa gcttttgccg atgaagacag tataactgcc attaaaaact acacagaggc 3243541 tgattacagc aagcctgatc aaagcaaatt cggtcttgca aaggggcgca atgtcatctt 3243601 tgtaacactt gagtcgaccc aaagctttgt tctgaatgaa aaagtaaatg gaaaagaaat 3243661 taccccattt atgaatgatc tcataaaaaa aagctattcc tttgatcatt tctatcagca 3243721 aacagaacaa ggcaaaacat cagattcaga atttatcgtc gctaactcac tgtatccctc 3243781 ccttagcggc gccgtctttt tcacgaaaag cgaccatcaa tttcatacga tgtataaatc 3243841 gctgaagcag cacgattatt attcagccgt ctttcacgct aaccataaaa cattttggaa 3243901 cagagatgtc atgtacgata catttggcat tgaccgcttt tttgatgttg atgattttca 3243961 tgtcactccc gggacatcga caagctgggg cttaaaagac aaagaatttt tagagcagtc 3244021 cgccaaaaag ctgaaaagcc taccgcagcc gttctacagc agttttatca cgttaacgaa 3244081 tcattttccg tttgagattg atgaaaagga tcagctgata gatgaattcg attcaagcag 3244141 tgatctgtta aaccgctatg tgaccacggt tcgctatgag gatgaagcat tgaagcattt 3244201 tatcaaaaaa ctgaaggacg aaggcttata cgaaaattcg atgatcgtat ttatgggaga 3244261 tcattacggc atttctgaag cccataacga ggcaatggct gagtttttag ggaaagacga 3244321 aatcacaccg tatgacaacg ttcagctcca gcgggtgccg tttatcatac atatcccggg 3244381 aatcaccgat caacagccgg aaaccatccc tgatgccggg ggacaggtcg acgtcaggcc 3244441 gacgctgatg catttgctcg gcgttgagac aaaaggcgat atccaattcg gcaatgattt 3244501 gctgtcgggc gaccgcaccc cattcgccgt tctgcgaaac ggcagcttta ttacgaacga 3244561 ttatgtatac acaaagaaca cgtgctatag ccaaaaaaca ggtgaagtgc tggaagatca 3244621 ggatgcgtgc ctcccttaca aggagaaagc aaacgaagaa ctgtctctct ctgataaaat 3244681 tttaaatggt gacctgctca ggttttccga atgaaaaaat ccctctatca agagggattt 3244741 tttacgtttc caatatcacc ttgccagtca gcttcgtttc atagccgttt aaatgagaca 3244801 gattcgcctt gtagtcctca gaattcaaaa tctccttcac ggctttgagc aactgctcat 3244861 tttttttcaa aacaacgata tcatattgtt cgtcgatgag cgggataaaa tcaacactgc 3244921 ccatatgtgc cgcgtgctgt gccccgattc ccgcgtcagc ctgtccgctt gaaacttgtg 3244981 aagcggcagc gtaatgatca gtcacgatat cgccatatcc cactacatca gccggattca 3245041 caccaagcaa gccaagctgt tcatcaagga gcacccttgc gccagaaccc ttttccctgt 3245101 tgatgatccg gatatcggct cttttcaagt ctttccagcc ttgaatgttt ttcggattcc 3245161 ctttttgcac atacagtcct gctttgcgga gaacgacatt gatgagacaa aacggttcac 3245221 ctgtcaaaat ccgttttaca taaggcgcgt tatactggcc cgtttctgca tcgtacaaat 3245281 ggaggctgac aatgtcacac ttgccttgat acatatcaat caggctgttt aagcttcctt 3245341 tgtatttacg gagcggcgtc tcctgaatgg cattctccaa atgcttgctg aggatatcca 3245401 tcgaaatgtc ctgtccgctg atcatgacat ttggtctgcc gtccggctca gcctcctgca 3245461 cctgtttcgg cgcttctttt gcagcgatgg gctgagacat tctcatattc gttttatatt 3245521 gctttaaatc ttcttcatcc acacgcatct gccttccgac acggtaagca ggcagcacgc 3245581 cttttttaat caagtcataa acggtcagct ttgatacctt cagcagacct gcaacttctt 3245641 ctatcgtata ggaagaggtt tcattcatca tcatcactct cctattttat tatacctttt 3245701 cgccgaatgt aaaaaaaccc acataaacca aacataatca gttataatta gttatatcta 3245761 atgataaggg gtgcaatcat gtttaagaag tattctattt tcatcgcagc cttaactgct 3245821 tttctgcttg tagcaggctg ttcttcaaac cagtcttcaa cggacagcga gaaaaaagta 3245881 acgttaacca tctcagctgc cgccagcgcg caggatgcac ttgaggaaat ccaaaaaaat 3245941 tatgaaaaag atcatcaaca tataaccatc caagataact atggctcatc cggcgccttg 3246001 caaaaacaga tttctcaagg agcaggagca gatctgttct tctcagctgc tgaggataaa 3246061 tttaaaaagc tggtggatga tggagatatc gcaaaaaaag acagcactga attagtcggt 3246121 aatgaaattg tgctggtcgt accgaaaaac ggagattcac ctgtgacaag cttcagcaat 3246181 ctggctgaat cagaaaaaat cgctcttggc actccggaat ccgtaccggc aggagcttat 3246241 gggaaagaat cactgacaaa gctgtcttta tgggacaaag tgaaggataa aattgtgtat 3246301 ggaaaagacg ttcgccaagt tctttcttat gttgaaaccg gcaatgtaga cgcaggtgtt 3246361 gtttataaaa cagatgccct agtctcgaaa aaggtcaaca ttgttgacga ggcaaaagca 3246421 gatacacaca gcccaattgt ctatccgtta ggaatcgtaa aagatacaaa acaccgtaag 3246481 gaagcgaagg aattttacga atacctgcaa tctgatgaag caatgaaagt atttgagaaa 3246541 tatggcttta ctgccgagta gcataagcgc ttcagaattt ttcacacccg ttgtgctttc 3246601 ctttcaggtg gcggcagttg ccggaattgt tgtcattatt ctcggaacac ttgctggagc 3246661 atggatgtca cgggcatcat ttttcggaaa aacggcactc gaaacatgtt ttatgcttcc 3246721 gctcgttctt ccgcctactg ttgtcggttt tattctgatc gtcattttcg gaaagcacag 3246781 cttcatcgga caagccatcg agtggatttt ccagcagcct gtcattttca cctggtgggc 3246841 cgctgtgatc gcctcggctg ttgtagcctt tccgcttatg tatcaatcag ccaaaaccgg 3246901 atttgctgac attgatcccg atatacaagg tgcggcaatg gtagacggcg ctagcagatg 3246961 gaaagtgttt atccatatct ccgtcccgct tgcctatcct tcgttactga ccggaagcat 3247021 ccttagcctt gcgcgggcgc tcggagaatt tggcgcaaca ctcatgtttg caggaaacat 3247081 ccccggtgtt acgcaaacac tgccgacggc gatatatgtc gcattggatt ccggcaacaa 3247141 tacccttgct tgggcgtggg tcgtctgtat tgttgtcatt tcctttttga tgctgttttt 3247201 cattcaacag aaaaaaacgc actaaaaaaa ctccccataa cggggagttt tttgattaaa 3247261 acagaagctc atcaggattt ggaccgacac gctcatcttt atttaatgcg tcaattttgt 3247321 ccatgtcttc ttgagacaat tcgaaatcaa aaatatcagc gttttcgatg atacggtgtt 3247381 ctttaatgga ttttggaatg gttacaactc catgctgcag atcccagcgc aaaatcactt 3247441 gagccacaga tttattgtgt ttttcagcaa tctgtgtcag tacttcgtta tccaaaagct 3247501 gtccctgcat gagcggagac cacgcttcca gctgaatgcc ttgccctttg cagtaatctc 3247561 ttaattcttt ttgcgtcaag cgagggtgaa attcaacttg gttcaccatc ggtttgattt 3247621 cagcatcttt caacagctct tctaaatgat gaacttggaa attgctgacg ccgatcgcgc 3247681 gaattttgcc gtctttgtac agcttttcaa gcgcgcgcca tgtatcttta tatttatctt 3247741 tgccaggcca atggatcaaa tataaatcta agtaatcaag ctgcagtctt tctaggcttt 3247801 tttcaaaggc agcaagcgtt gtttcatagc cttgatcttc attccacact tttgatgtga 3247861 tgaagagctc ttctcttgcc acaccggatt ctttaatccc gatgccaacg ccttcttcat 3247921 ttttgtagat cgctgctgta tcaatactgc gatagccatt tttaattgcc gctttcactg 3247981 attcagtcgc ttcattacca ttttctactt taaaaacgcc cagaccgaac caaggcattt 3248041 caactccgtt atgtaacttt acagtatctt ttaaacttgt tggcacttga acctccaccc 3248101 tttcactgaa atgtaagcgt ctatattatc tcacattcct ctcagccgat accaataata 3248161 cgcttaagac cctctttttg cttctttttt cacagcacag gcaaatccaa acactatttt 3248221 tttcctattt taacaatatt gagattacaa atacattgag cagggtatgc gtgtagtgta 3248281 accaaatgaa aacaaaggag gaaacaactt gaaacgtatt cgtatcccaa tgacacttgc 3248341 tcttggtgcc gctttgacaa ttgccccttt gtcctttgct tccgctgaag aaaatcctgc 3248401 tccgaagatg tcgcagacaa ctactgctgg aacaactgcc gctgatgtag gtttaaacgt 3248461 caacctggat gtacttggaa ttgccaacca gatcgctgat gccatcaaat ccgcacagaa 3248521 tagggatggc tttgtgaaaa acctcatgga gtcttccttc tacgcgtccg gccaaaaata 3248581 taacgtcatg gtctttaatt taagccagga atatgaagat catttgaacg gtgtgcaatt 3248641 ttacggctca gccgtttacg acggcattac gtatggcatt tgggtatttg aagatggaac 3248701 ctttacaaac aaaggcgatg gcggctggat caactgggcc ttcagaggct ggttcgaccg 3248761 ggatggcagc actgtcgcat ttcatcgccc ttaatataaa aaaagctggc gctctaacgc 3248821 cagctttttt tctgcattta ttcgccgcct tcaagcatgg cggcttcgac atcattaatg 3248881 tattggcgaa gctcatggga gatgtcccgg gaaatttccc tctcttcgaa gagcgtttga 3248941 atttcatttc tgatcgcctg cacagccttc agcttcactt ccagcttctg attttcaaaa 3249001 tgggcacttg attttaactc atgatggctg tgctccagcc tgaaaattaa ctgcttatag 3249061 aatgtaatga cagataaaaa cacttcttta tgctcatccg tcttatgttt ttccagatat 3249121 tctatcgctg cttttgccgt tttcactctt gttgcccgta tcaatcccgc ttcatttaaa 3249181 atcgacatct ccggcttttt atgttcaccg aagaaaatcc aatacatcag cctcttgagc 3249241 cttgtttttg ataacccgac tttaaacggg ttggcataca aaatttccaa ctcgttaaat 3249301 cgttcttgca gcacatttgc tgtttcttcc gggatgtctc cccgctccag cattttcatc 3249361 agcgcctctt gctcagcctt aaccccctgc gcacggactt ttcgctcgtg cttcttaatg 3249421 cgattagatg atgtatactg ctgaaaacga agatttttca ttttctcatt gtattcagct 3249481 atcaccgcaa gagaggccgt tttgtttgtc tcattcatgt cctctttaat cgtttgaagg 3249541 gctgttttga tcaacttgcg tctcgccgtc agcagcttct tatttcgttc ctcgtcctct 3249601 tcttcttttt cagtcagaat tggcagcaca acggtggcaa tgacaagcgt gcataaaatg 3249661 acgccggctg ctaaaaagag aatcagattt ctttccggaa acggcgtacc gtcctccagg 3249721 aaatacggaa tggaaaaaga acctgcaagc gttactgctc cacgcacacc ggaaatcgaa 3249781 attaacagcg tcgaacgaag acccggttta tagatgttct gatctttatt aaagaaccat 3249841 ttgccgttcc agaagaacag cacccacagg aatctaagga gcattaatgt aaatgtgatg 3249901 actaggatat agccgatcac cttcatgttg ctgatggcag tgtcgttaaa gataacagaa 3249961 ataacatcag ggatttgcgt gccgagaata acgaagacca ggccgttcaa aataaataaa 3250021 ataatgttcc acgtacttga ggagacgatt tgcagcttga tcatcgttga ttccagacga 3250081 tcctgttcaa ccgcatgggt aataccgcca gctacaacag ctaaaatgcc cgaaacgccg 3250141 atttcttcag ctgccaaata aatcacaaac ggcgtcagaa tttgaatcag catatgcatc 3250201 gtgacatcct gcatgccaag gcggcgcaga aataggcgaa aacgaataat caaaaatgaa 3250261 atgacaaccc cgcacagcaa gcctccgaga gaaataaaga caaagctgac agccgcttgt 3250321 gctaatgaaa atgcaccagt cactgccgct gcaatcgcaa acttaaaggc caccagacct 3250381 gatgcatcat tcatcagccc ctcaccttcc agcaggcgaa gaatcccttt tggcattttc 3250441 actcttcctg ataatgcgct gacagcgacg acatcagtcg gtgaaagaat ggccgcaagt 3250501 ccaaaggccg ctgccagcgg aatagcagga atcatccagt gaatcgtgta gccgcctaca 3250561 atcacagtcg caaatacaag gccgagtgca agcaataaaa tcggagccct taaattccaa 3250621 agctctgccc gcggtgtcct ctttccatca ttaaatagca gaggcgcgat aaaaagaaca 3250681 aaaaacaatt cggtgtttaa ttcaaaatga agtccctgtg gaaatgaggc ggcaagaatc 3250741 ccaagagcca cttgaatcag cggcaccgga ataaacggaa taaaccggtt cacgatatta 3250801 gaaatcgcaa taatcgttaa taatacgagc acaactaaaa atatgtccaa atgcatgacc 3250861 tccttcgtct gttgtgtgtc ggcatgatga gccaaaaaat ctgtttgtct aaaagccctt 3250921 gagctagggt ggccttgcat ccgctatgtg gtttcgcagg agttctctcc acacttgtct 3250981 tcttttatag tacccttttt agggtatttt ttctcatgat atgctcacag tgaacttttt 3251041 tgcagaagag caaattatag aaaaaagaga caggaagcta ctccctgtct ctcgtctttc 3251101 tttctcaatc atgaaaattc gtaccgtcag ttgttgcttt aataatgccc gcgcgaatga 3251161 caaagtcacc gaaatgctcg ccttcctcgc gttctttcgc atagcgggaa agaaggatgc 3251221 gcagctcgct taaaatgtct gcttcaccga tgttttcacg gtacattttg cttaaacggc 3251281 ttccgtcaaa cgcagcgcca agatacatat tatatttgcc cggcgccttt ccgataaatc 3251341 cgatctcacc gagtgcatga cgtgcacagc cgttcgggca tcctgtcatg cgaatggtga 3251401 tttcctgatc acgaaggccg ttttcgtcaa taatctcttc aatcttatct aacagggtcg 3251461 gcaaataacg ttctgcttca gccattgcca atccgcaggt cggaagagcg acgcacgcca 3251521 tcgagctgcg gcgaagcgct gaatagtgct tgccgtcagt tagtccgtac tgttcaatta 3251581 aagcactgat ttcttctttt ttatcgcttg aaacgttcgc aatcattaag ttctgattgg 3251641 ctgtcagccg gaactcacct gtatgaactt tggcgatttc ccgcaagcca gtcatcagct 3251701 tataatcatc gtaatccgtt atacggccgc cttcgacaaa cagcgtgaaa tgccatttat 3251761 cctcgatgcc ttccacccag ccatagcggt cgccgttatg atcgaaatga tacggcttcg 3251821 cttcttccag gctccagccg agacggtttt ccaattcttc ttttacgttt tctaaaccga 3251881 ggcggtcaac tgtgtatttg aaccgcgcat ttttacggac agaacggttg ccgtaatcac 3251941 gctgaatcgt aatcgttttt tcagcaacgt catacatttg ctcaggccgg cagaaaccga 3252001 tcaccttggc taattgcgga tatgtcgcag tatcgccatg cgtcattccc ataccgccgc 3252061 cgattgccac gttaaaaccg atcagcttgc catcctcgac aatcgcaatg aatccgagat 3252121 cttgtgaaaa gacgtcaata tcattagacg gcggaacggc aataccgatt ttaaacttcc 3252181 gcggcagata gagcggtccg tacattggct cgacttcttc ctccggcgtg ccggcaactc 3252241 tttcctcatc aagccaaatt tcatgatatg ctctcgtccg cggcagcaga tcatcactta 3252301 attttttaga ccactcgtat acctctgagt ggatttcaga ttgataaggg tttgatgcac 3252361 acatgacgtt acggtttacg tctccgcagg ctgcgatcgt atccaaaagt gctgagtgga 3252421 tcgtctgaat ggttttcttc atgttccatt tcagaattcc gtgcatttgg aatgtttcac 3252481 gtgtcgtcaa ttttaatgtg ccgttcccgt atttctggga caggtcatcc atgacaagcc 3252541 attgttcagg cgtcgagacg ccccctggca tacgcacgcg cagcatgaac tgatatgcgg 3252601 gctcaagctt ctgcttttgg cgttcatttc ggaggtcgcg gtcatcctgc aaataactgc 3252661 cgtggtgttt catcaggcgg ttatcatcat ccggaattcc cgcactgatt cgatcgagca 3252721 tcacttcttt cagcgtgccg cgcaaataat cactttcttt tttaatgcgt tcaacatcac 3252781 ttggagagcc gtccggtgct tttagaattt tggtcaccat gttgaaaaac tcctttcaag 3252841 tcaaatcaat atacatcacg ctgatagcgt ttttgctgct gcatatcggc aagataagcc 3252901 tccgcctctt cgcggctcat attgccttct ttttcgataa tttcaagcaa tgtgttatgg 3252961 acgtcatgcg ccatgtgctt ttcatctccg caaatgtaaa cagccgctcc ttcttgaagc 3253021 cattcaaaca attctgcgct atgttcaagc atgcggtgct gcacatatac tttttcttcc 3253081 gtatcacgtg agaacgccac atccattttt gtcagcacac cgtctttgag ccaattctgc 3253141 cactctgtct ggtaaaggaa atccgtgaca aagtgctgat cgccaaagaa catccatgcc 3253201 tttccttccg ctcccgtctc ctcacgctcc tgcataaacg aacggaaagg tgcgacgcct 3253261 gtcccagggc ccaccatgat aatcggtgtt tcagggtctt tcggaagctt aaagttttga 3253321 ttgtgctgta cataaaccgg cagtgtgtct cccggctgca gtcgttccgc gcacaaaatc 3253381 gagcagacgc cttttcgttc acggccgtgc gcatcgtagc ggactgcgcc gattgttaag 3253441 tgcacttcat ccggatttgc ggataaactg cttgcaatcg aataaaggcg ggcaggcatt 3253501 tttcgcaaaa tcgagacaaa ctcctgcgca gatacactaa atgggccata gtcacggacg 3253561 agatcaagca aatcgcgccc ttcaatatag gcttttacat tctcctcatt tcccggggct 3253621 aaaagctctc taagctcatc gttccctgtc agctgggctg cctgttcaag aagcggtttt 3253681 gtgagaacgg taatctcata gtgagaaatc agcgcttctt tcagcggtcg gacatcacct 3253741 tgcttattaa gcgtcacaat ttcttccggg tcccaattca tttccttaag gagcagctcg 3253801 acaagttccg gatcgttttc cggatagacg ccgaggctgt caccaggctc gtaagtcagg 3253861 ccagatcctt caagagacag ctccacatgg cgtgtttctt tatttgatcc tctgccgttt 3253921 aaatttaaat tttctaacac ttcagcccga aacgggtttg ttctggaata cgaagactca 3253981 ccggtttgtg acgcagccgc cggcgcaggc gcggcgcttc cgcccccagc ttcatttaat 3254041 cctttcaata caccctcaag ccattcggct gccggttcat catagtcaag atcgcaatca 3254101 acgcgcggag aaatccgttt tccgccgagt tcttctaagc gttgatcaaa ttctttccct 3254161 gtctggcaga aaaattcgta cgaactgtca ccaagcgcca aaacggaaaa gcgcaggtct 3254221 tcaagcttag gcgcccgtct tccgtgcaga aattcatgaa acgacagcgc gttatcaggc 3254281 ggctcgcctt ctccatgcgt actgacgacg attaaaagat tggttacctt cttcagctga 3254341 ttcggcttaa aatcgctcat ggatgagacg gtcacttgaa aaccgctctg ttcaagctgc 3254401 ttgccggcat tttctgcaag cccctgtgcg tttcccgtct gtgaaccata aagaacggtc 3254461 acttcttttg aaacggccgg tgccggtgct tccgctgaca cagctgccgc cggcgtaccc 3254521 gcagcttctt gggcggaaac agattgagcg gataaatatc cgctcagcca gattttctgg 3254581 gattcggtca aggtcggcag aaggcggtta aggagctctg cctgctcctg attaaacgga 3254641 ctgttcatta cctgaagttg caacgtatcc acctcacaaa gttataaact gatcgaaaat 3254701 tgcatctaat tgaactttac cggaatacta ggcttaagta aaatatattt acatgatgat 3254761 aactattaag aatcctaatg ataaaacggc tatgcttcat gtaaatagaa aaaagagaag 3254821 gactcccttc tcttcattca gcaatctgat ataagtgagg cggcacagcg gttacaaacg 3254881 gactggcttc acctgtataa aataccgcca gcatgtgcat cgcacgggtg cacgcagtat 3254941 ataaaagcct gcggtcgtgc tctgtatgat agtgttcttc agatgcatca tagacaagca 3255001 ctgcgtcaaa ttcaattccc ttcgctaaat acaccggaat cacgcaaaca cccttttgaa 3255061 atggttgatt ttctttatga atcaggcgaa catctgtata ttcactcatg tgggcgtgcg 3255121 cctgtatgca ttgatgcgca gtcttgcaga tgacggctat tgtttcgtgc ccttttttct 3255181 tgagccggcc aatttcttgc gcgagctttt ggcaaaggct ctcatgtcct tcagttttga 3255241 caacgagcgg catttccccg cttctattaa acggctcaat atccgctcca tcttgaagca 3255301 tcgctttggt aaactcgaca atctgccttg ttgatctgta tgttctcttt aaacgaacat 3255361 actcagcagg ctcatcctca aagcacgcat ccatacgctg atccccgttt atggtatgcg 3255421 cgtagatgga ctgattgata tcaccgagca ctgtcatgct ggcagccgga aaaatgcttc 3255481 tcatgtaagc catctgaaac ggtgaatagt cctgggcttc gtcaataaat agatgtttga 3255541 ttttcgtatt tttctttctg ccctcaatca gatcctgcat ataaagaaac ggtgccgcgt 3255601 cctcatagag caatttatta tccgtaaatg ccgaacgggt cagctcacct atcgcatcca 3255661 tcttctcatg ttgaaatttt cctccccagc cagaaaacaa ttgcaaataa agttgtgtaa 3255721 catcaagaaa tgcaaggagc ctgactgcct gtttgagcgg tttgaaagct tttttcacaa 3255781 tgatggcggc aagcagctgc tgctctcttt gataatcgtt aaacgtactc tcgctgaacc 3255841 gtttcctttc ctgcagtttt ttgtacacgt ccaagtagtc ctctttgtca agcagctcag 3255901 cttcatgaac aacccaatcc tttcgccgtt cctttttctc aagcttgtta agctcactca 3255961 gcagccactt cgcggtttgc tccatccgat tcggaatgga gtgattttga tccaatgagt 3256021 aaaaatagga ttgaatttgc tcctttgtga tcagcttttg tccgcggaat ataatatttt 3256081 taaaaatcat cccttcagag gaaagccgtg tgacgtattc attaatgaat tgctgaaagg 3256141 ataaacccgc cttccatgtg attcctgcaa gccttgttgg aaaatcgcct ccctttgttt 3256201 cggtcaggca atattcgagc tgatcaaagg ggctttcaca tttgaacttg cggccaagac 3256261 gatgctcgat atattcctga aacgtcgcct gctccatatt ctcttctcct aactccggca 3256321 aaacagagga gacatagctg ttaaataaga agttgggtga aaacaaaacg atttgtccgg 3256381 catcaatgac accgcggtgc ctgtataaca aataagcgac acgctgaagc gcagccgatg 3256441 ttttcccgct gccagccgct ccctgcacga tcaggatctt gcttttttca ttacggataa 3256501 tctgattttg ttctttctga atcgtagaca cgatgttttt catttgggta tcagagtgat 3256561 ggcttaatac ctcttgcagc atttcatcgc caatcgtcat atcggtatta aacatcgcct 3256621 tgagagtgcc gtttttgatc ataaactggc gtttcagcac catttcccct tctatcgttt 3256681 caccgggcac ctcgtactcc gcttttcctg gggaataatt gtagtacaaa cttgatatcg 3256741 gcgccctcca gtcatagatc agaaagtgtt cctccttctc atccaaacag gaagctaaac 3256801 cgatataaat tcgctctgcc tgctcctcgc cgttttcaat aaaatcaatc cggccgaaat 3256861 aaggcgattt tttcaattga tgaattcgtt tgagctgctg atccatgcgc cgatgattgt 3256921 gttcccgatc agacagcagc tctgcctgct gcttaatgct agccatcgtt tcaatcgctt 3256981 catgggcatc atcaaaatta accttaacat cctcccaaaa gctttttctt aatccgatga 3257041 tatcatgctt caacccgccc gcagacgttt ccagaaaccg ctcttttttt tcgagctcct 3257101 tcagcacctc atctattctc gactgctctt ccttccattc cttatcctgc tgattcatga 3257161 acggcacctc cagaaaatag ttgacaaaca tagatgaaat actgtaaaat ataattggat 3257221 acatatatta aatatatgat gcaaactggc aaatacaatt tataatagca cattcaccca 3257281 ataccaatca aggtttgggt tatttatatt atgcagaaaa aaaccgattt cacttcgaaa 3257341 tcggtttttt tgctattaat tatctaagcg aaaagaacgg tttggcagct tccaattaaa 3257401 catataggaa caaacccggc aaacaacgag cacgaaaaac agaacgtata agccgaacga 3257461 gttccccagc cagcccaagc cgacgattaa accgccgagc gccgcccata ccgcatagat 3257521 ttccgctttc agcacaagcg gtttgcgccc ggcaagaagg tcgcggatga tcccgccccc 3257581 gcttcccgtc agcaccgcag ccacgatcac ggcactaagc ggatggccca ttttgacggc 3257641 atacagtgcg ccttggatag caaaggcagc gaggccgatc gcatctgata aattgcccca 3257701 cttattccaa tgcttcagca gcagcttcgg aaacagaaac acaattgtaa tagataaaag 3257761 cgcgatttga aagtacgctc cctgctccca tagcgctgac accggaacac cgatcagcaa 3257821 attgcggatc gctcctcctc caaaagctgt gacaatccct aatatataaa ctcctaaaat 3257881 atcatattcc tcttccatcg caacaattgc gccgctgact gcaaacgcaa tgatgccaat 3257941 cacactaagc agctcccaag ccattctgat gactcccttt tatgtttgtt aaattttctg 3258001 acgacctcta gattttataa tcgctccagc gtaaaatcaa taacattttc atgagaaaaa 3258061 aagataaatt tagagggaat acggctattg ctgatggaca tgagtttgcg aaattaaaaa 3258121 agcgcccggc atacgcgggc gctttttttg ttattcagat ttttcgcctt tcagcaggca 3258181 cataaaaatg ataatcagga taaaagcaat cagggccagg aatggaatcg taataaaacc 3258241 aaaccagtta atatattggc ccgagcacgg cacgccgctg acacatggct taatgccgct 3258301 aaagccgggc actttttgct ctaagtaatg catgatcgaa atgaatgccc caataatcgc 3258361 catcgggagc acatattttt tcactcgtgt gtccccttga aaggtggcga tgcctaaaat 3258421 caggacgagc ggatacatga ggatacgctg gtaccagcac agttcacatg gaataaactt 3258481 tctgatttca ctgaaataca ggctgcccag catagcgata agagccacaa cccaggaagc 3258541 atataaaaat acgattctat ttttcatatt gttacttccc tttcagctct ttttctattg 3258601 tctctttgat ttcatcataa tccgcaaaat ttttgatcac tttatcattg acgtaaatcg 3258661 tcggtgttgc ctgtatgttc attttttgat taaggtcaga atccttttcc acttgagaag 3258721 cgaatgtttc cttatcaaga ttttccttga gcgtctcagg ttttatcttt gtggtgcttt 3258781 ttgcaagatc accaaggagg cctggggtta cccattcctg ttccgtatcc ggctgttttt 3258841 cgaacagctt ttcatggaaa tcccagaaag agtcagggtc ttccttccat acttcttcag 3258901 atgcaagagc cgctaacctt gaaccttttc catggaacat gacgttcacg aaagaaaatt 3258961 tcacatcgcc cttatcaata aagtcttttt gtatttttgg aaagatgtca ctgttaaaca 3259021 ccttgcaaga cggacatttg taatctccga attctactac agttaccggt gcatcgtcct 3259081 tgccaagcac aggctgccct ttgatagacg gctgtccgga caccgcatca ttgccttgtt 3259141 ccgttttgtt attaatgatg acaatggctg ctagcaatac aacaaccaca accgtaagga 3259201 tgaccgcgaa tttcgcagaa gactgctgtt tctttttcac tccgacacct catcgtttta 3259261 aaattaaaaa agaagcggat cgcaattgac ccacttcttt attttaacaa gacaagcgct 3259321 gataagaaaa ccccgaaaaa atgaattctc tccgacaatt tatttgtttt tgagacgcat 3259381 gacgcgcatg gcgttcgcca cagcaagcag tgtaacgccg acatctgaga aaaccgcttc 3259441 ccacatggtc gcaattccaa atgcaccaag aatgagaaag atcgctttca cacctaaagc 3259501 aaagccgatg ttttgccaca cgattcgccg tgtccgtttc gcaatccgaa tcgcttctgc 3259561 tatttttgac ggctgatctg tcatcagcac gatgtctgcg gcttctaccg cggcgtctga 3259621 gccaaggcct cccatcgcaa cccctatatc tgcgcgtgca agcaccggcg tatcattgat 3259681 gccgtcaccg acaaaaatga gtttttcact aggcaaaagc ttagcttcta atgcttcgac 3259741 ctgcgcgact ttatcttgcg gcagcagctc tgcatatacc tcaccaatcc caagctgttt 3259801 tccgacggct tctcccgttt gtttcgaatc acccgtcagc atagctgtct gtttgatccc 3259861 aagcgacttc agatcagcaa ccgcctgtgc tgcgtcttcc tttatctcat ccgctatgat 3259921 gattgctccg gcatagcgtt gatctacagc aacgtgtacg attgttccag cattttcatc 3259981 cgggacatcc tcaatttgtt ctctttccat gagcttttta ttcccagcaa ggatctcagt 3260041 tccatttacc tttgcaaaaa tgccgtgacc ggagatttct tcgtatgact caatctcatc 3260101 ggaggaaagc attttcccgt aagctttacg cacagattca gcaatcggat gctgtgaatg 3260161 aagctcagcg tatgccgccg cttcaagtaa tctatccttt gtaaaacctt ccgcgggttt 3260221 gatttctgtc acttcaaagc tgccttttgt tagtgttccc gttttatcaa acaccgcgta 3260281 tttgacttga ttcaaagctt ctaaataatt gcttcccttt acaagcactc cggcctttga 3260341 ggccgctccg attccaccga agaaaccgag cggaatagag acaacaagcg cacaaggaca 3260401 agaaatcact aaaaagataa gcgcgcggta cacccaatcg gaaagcgcgg cgccagaaag 3260461 aacaagcggc ggaacaaagg ccagcaatac cgcaatgatc accacagcag gtgtataata 3260521 cttggcaaac ttcgtgataa agttttctgt ccgggcttta cggctgctcg cattctgaac 3260581 caagtctaat atttttgata ctgctgattc ctgatagccc tttgtgactt caatatgcag 3260641 aacgccgttt tgattgataa agcctgacat tacatcttgt ccttccgcag cttttctcgg 3260701 aacggactca cctgttaaag cagatgtatc aaccatcgct gacccttgca cgaccttacc 3260761 gtccaggggt atgctttctc ccggattaac cacaatgatg tctcctgtct gaacgtcctc 3260821 cgacgaaacc tgttcgatgc cgttctttgt tttgagattg gcgtaatcag gccgtatgtc 3260881 cattaacgca ctaattgatt ttctggaacg gctgaccgcg gctccttgaa aaagctcacc 3260941 gatttgataa aacagcataa cggcgacccc ctcagggtat tgctgaatca gaaaagcgcc 3261001 gattgtggca agagccatta agaaatgctc atcaaacacc tgaccgcgga tgatgttttt 3261061 gactgcgcgg attataatgt caccgccgat aatcaaataa gcaccgagga aaaggaaaaa 3261121 ttcaatggtt cccgactgaa ccaaatatgc cgctgcgccg agaatgacag ccgccgccat 3261181 tctgatcagc atattgacca ttcgattacg atagccatca tcagctgatt tctttatatg 3261241 cttttggcga accgttacat gcggatcaat tgatttcact tttttctcta ctttattcgt 3261301 gacccattgc tcttctttcc catcggctga gacagttaag gtgcttgccg caaaatttac 3261361 cgcgcatccg ttaatgcctt ttatgccttt gactccattt tcgatttttc gggcacaatt 3261421 gctgcaatcc aaaccgtcca gaacatattc ctgtttcact agtctcacct taccttccga 3261481 tttagggttc cctcttcaaa gcgtatcaat gagtattgta tttattttat atatatgagc 3261541 atatactcat atataagtta cacctattat atgttgtttt ccaagaaagt gtcaatgaaa 3261601 aacaaaaacc ggcatatagc cggtttttca ttttactttt tgcagacgaa gagcattcag 3261661 aacaacggaa acggagctga atgccattgc tgctcctgct atccacggtg ctaaaaatcc 3261721 aagtgctgcg attgggatgc cgaggctgtt atagccaagc gcccagaata agttttgttt 3261781 aatgtttttc attgtcaatc tgctcatgcg gattgcgtcg gcaatgctgt tcagatcgcc 3261841 gcgaataagt gtaatgtctg ctgtttccat ggcaatgtcc gtgccagttc caatcgccat 3261901 gccgatgtca gctgtggcaa gcgccggcgc atcgttaatt ccgtcgccta ccattgctgt 3261961 ctggcggcct tctttttgca agcgggcgat ttccgccgcc ttttgttcag gaagaacttc 3262021 cgcaatgata ttcgcaattc ccgcttcctt cgcgatggct tctgcggttc tgcgattgtc 3262081 tcctgtcatc atgatgacat caagacccaa ctctttcaga cgggcaacag ccttccgcga 3262141 cgtatcctta atcgtatctg caactgctac tagccccgct gcttctccat caatggatac 3262201 aagcataact gttttccctt cggcctctag ctcttccatt tgggcgagaa gagccccatg 3262261 ctcaacctgt tcgctctcca ttaattttct tgtgccgacg agaatgcttt ttcctccggc 3262321 ttcagccaaa atgcctgcgc cgacttttgc ttcaaagcgg gtaagtttcg gtatctcaag 3262381 ccctttatct ttcacgccag caataatcgc ttcgccaagc ggatgctctg atcccgtttc 3262441 cgctgccgct gcaaattgaa gcaaatcttt ttcttcaaaa cggccgaatg gaatggcatc 3262501 cgtcagacgc ggcttcccgt ttgtcacggt tccggtttta tcaagaacaa ttgtatcgag 3262561 acgatgtgtt ttttctaaat gctcgccgcc tttaaataaa atcccgaatt cagcagcgcg 3262621 tccagatcca gccattatgc tcgtcggagt ggcaagaccg agggcgcaag gacaggcaat 3262681 gacaagaacc gcaatgaact tgctgatcgc ttcggcaaaa tcgccaggag ccgcccaaag 3262741 ataccaaatg agaaaagtga gaaccgcaat ccccaataca atgggtacaa aaatgcctga 3262801 aatctggtca gcgagacgct ggatcggcgc ttttgaccct tgtgcttcct caacaatttt 3262861 gatgatatga gaaagcgcag tatcctttcc gacgttgaca gctttaattt tcagaaagcc 3262921 gtttgcgtta acggttgaac ctgtcacgct gtcaccagga tttttgtcaa caggaagact 3262981 ttctcctgta atcatcgatt cgtcaaccgc tgaacggcct tcaaccactt ctccgtcgac 3263041 aggaattcgt tcgccaggtt tgacgtaaac aatgtcatta acaagcactt cgtcgatcgg 3263101 gatgatttgc tcctgtccgt ctcttacaac agtagctgtt ttcgcttgaa gcttcatcag 3263161 ctttttaatc gcatccgagg aacggccttt tgcttttgtt tcaaacaact tgcctaataa 3263221 aatcagcgtc agcaaaatcg cgcttgtttc ataataaagg ccgtctgtat gcccgtgaga 3263281 gccaatgctt tgaaaagtta gataaagact ataagcgtaa gcagccgtcg taccgagggc 3263341 gaccaataca tccatattgg cgcttttatt tctaagcgcc ttatacgcac ccacataaaa 3263401 cggccagccg atcagaaact ggactggtgt cgccagcgca aactgcatcc acggattgag 3263461 aaatatatcc ggtacccaaa tgaatgatgt aaatgtaaaa tggctcacca tcgcccaaag 3263521 caatggaaat gacaggacag ctgaaaaaat cagtctcgcc gtttgcttcc gttcttcttt 3263581 ctttttagca gcagcctcac tgtcctgttc acccttcaac tttagcttat atccaagctt 3263641 atctaccgct tctttcaaat cgctgacaga cgcttctttt ggattgtatt cgaccgtaac 3263701 tgtttctaaa gcgaagttta ctggtgcatt tgcgacgcct tctattttgt taagccgttt 3263761 ttcaatccga ttggcgcaag ccgcacaggt catgccctca atatcgaatt cagctttttc 3263821 tgtaacgacg tgatagccca gcttctctat tttttcctga atcgctgcag tccctgtttc 3263881 agcaggatcg tagattacat ttgatgtttc cgttgccaga ttaacatttg catccgtgac 3263941 accgggcatc cgcttcaggc ctttttcaat tctggcagca catgccgcac aggtcatacc 3264001 agagacctgc atcgcgattt ccttttgttc actcaacata ctcactcctt tatatacacc 3264061 tggggggtat ataaaaatga aagaaatatc gcgcctccct aaaggcgcga taccttgaat 3264121 cacttggcta cgtcatagcc ctgatcttct atcgcatccg caatatcttt gactgatact 3264181 ttgtcagcat caaacgaaac atcgacttta cccgcttcca gattgacatg aacggcactg 3264241 acgccgtcca gttctcctac gcttgtttct actgctttga cgcagtgctg acaagacatt 3264301 ccttcaactt gcaatgtttt ttgttccata tcaattcctc ctgtttattc tttctatttt 3264361 catcctacca tacccccgta gggtattaca ataaaaaacg ctttatgatt ttgtgaactt 3264421 tttaaatacg tccaaaagct cagaaatggc ctgttccccg tctccgcttt tgatggcatc 3264481 tgctacacaa tgatgggcat gatcctcaag caaatgaagc gccacatttt tcattgccgc 3264541 ctgaacagct gaaatttgca caagaatatc tacacaatat ctgtcgtttt ccaccatgtt 3264601 ttgaatgcct ctgacctggc cctcaatccg cttaagccgg tttgtaatct gatccttttc 3264661 tttcgagctt ttatggttta atgttttatg ttcgttatgc ttttccatgc gtacacctct 3264721 gtttaatgat attaattccc attatactga ttgtccaaac ggttgtctaa gcatgccgac 3264781 gcaaaaaatg aatcagttag gttttaccat ttgatcagga gggtatatac ttctgttgat 3264841 aacgctttta aaggggagaa gaaaagtgga tacgatcaag gttggaatat taggatacgg 3264901 attgtccggt tctgtttttc acgggccgct gctggatgtt ctggatgaat atcaaatcag 3264961 caaaatcatg acatcacgga cagaagaagt gaaacgggat tttccagatg ctgaggttgt 3265021 acatgagctt gaagaaatca caaatgaccc tgccattgag cttgtcattg tcaccacccc 3265081 gagcggcctt cattacgagc atactatggc atgcatacag gccggaaaac atgttgtgat 3265141 ggaaaaacca atgacagcaa cggccgaaga gggggaaaca ttaaaaaggg ctgccgatga 3265201 aaaaggcgta ttattaagcg tatatcataa ccgacgctgg gataacgatt ttttaacgat 3265261 taaaaagctg atctctgagg gatcccttga agatatcaat acatatcaag tttcctataa 3265321 ccgctacaga cctgaagttc aagcgcggtg gcgggaaaaa gaaggcactg ccactggtac 3265381 gctgtatgat ctcggctccc acatcataga ccaaaccctg catttgtttg ggatgcctaa 3265441 agccgtgact gcaaacgtga tggcccagcg ggaaaatgcc gaaacggttg actattttca 3265501 tttaaccctg gattatggca agcttcaagc cattctatac ggaggatcaa tcgttccggc 3265561 aaacggacct cgttatcaaa tccatggaaa agattctagc tttatcaaat atggaattga 3265621 cggacaggaa gacgcactca gagcgggaag aaaaccagag gatgacagct ggggtgcgga 3265681 tgttccggag ttttacggaa agcttacaac cattcgtggc tccgacaaaa aaacagaaac 3265741 gattccatca gtaaatggct cctaccttac ttattaccgt aaaatagcgg aaagcatacg 3265801 agaaggtgct gcgctgccag tcactgctga ggaaggtatt aatgtcatcc gcatcattga 3265861 agccgcgatg gaaagcagta aagagaaacg aaccattatg ctggagcact aaaacaaaag 3265921 cctccccaaa taaggggagg ctttttcatt agaatgtttt tcctgcttct ttcgcacgcg 3265981 caatcgcgtc ttctttgatt tgctgtgctt tatcaggctc cgcattatgt ccctctacga 3266041 aaatgccatc gaatgatggt acgccgaaga agttcatcat gatgccgatg tagcggtgcc 3266101 ccatttccat ctcagccgca gggccttctg aatagtagcc gccgcgcgct tggatatgaa 3266161 ttgctttttt atcagttaac aagccgacag gaccttgttc tgtgtatttg aatgattttc 3266221 ctgcaacagc aacagaatcg agatacgctt tcatcactgg cgggaatgag aagttccata 3266281 aaggagtaac aaatacgtac ttatcagctg atgcaaattg atcgctaagc tctcccaaac 3266341 ggcctacttt cgctttttcg ctttcagaaa gctcttcaaa gcctgtacct gactgaagct 3266401 ttccccatcc gctaaataca tctgcgtcaa tgtgcggaat gttttctttg tacaaatcga 3266461 tatgtacaac ttcatcattt ggattcgctt ctttgtaaga ttcgataaat gctttacctg 3266521 ttgccatact gtacgaagtt gcttcgtcat gtggatgagc agtgatatat aatacttttg 3266581 ccatttttac cagccctttc gtttttaaaa atcacacatc aattattatc atacagatgc 3266641 ataatgatta ttctgtctct cttagacttt attatagaga caaagaaatt tactttcaag 3266701 taaaacatct cgaattaaag attatttaac tttcccaaac agcttacttt tcaaaagctg 3266761 ttctcaagcc ggaatacagc gcggacaatt ctttactgat ccgaggataa tgagggacat 3266821 gcggcacttg aatatccgca ggcatccttt tcatgataaa ggattgctca gcctgttcaa 3266881 aaaacgcccg cagctggttg atctcttcat cagaaaacgg agcagacgga cggcggtgag 3266941 cttgcgccga gagcaaatag taccctaagt gctgagcacc ggaaatggca ggccagagcg 3267001 catccgcatt cgcgtgagga aactcgccaa gcgccttgtc atacgcatcc cgaagcctga 3267061 caagactcac ccttaacttg tgttcgtcgg caatttgccc ggttaacagt ttctccataa 3267121 actgcccttc cagccggatg acattccgca caagttctgg cagccgcttg gttgaaaacc 3267181 gccgccacaa aagcattgtt cccaacagcc cgatcacgct gccgacagct acatcagtca 3267241 gcctcgctat cataaaataa ccggcgcccg ccccgccatg catactttct gtgataacaa 3267301 gcgcatttgc ggttaaaaag ggaacagcca gcgcataatt gcggacgatc agcatctcaa 3267361 gaagacattg cagcgctgca atacaaaacg caatataaac accgcccggc ttaaaaaaca 3267421 ggattgcgcc tgccagtata acaccgatca ccgttccggc cgaacgctga atagccctgt 3267481 gaagcgtaaa aacaacagta gtgccaagca tgaccgctgc tgccgaaagc ggaatccaat 3267541 aggagcgtgc aaagccgaat gcgagggcaa acatatcggc ggcaaacaga acaattccgt 3267601 actttaacgc tctaatcaaa actggagact tccagtcaaa ggcatttctc aaaaagtaaa 3267661 aagaggatgg caggcggctt ggttccccgt caagctgctt atcaaaacgt cctgaagcga 3267721 tatacaaaac ctcattgatt tcttcaaaca gcttccgcct aggctcagat tcattttcat 3267781 taatctgaaa cgtattgaaa acccgtgcat tcgcaagcat atctccggtt tggcgaagtg 3267841 ccttttcaat ctgcgcggtc tctctgtccg gcgtttcagc tgaaaaatga ataatggcaa 3267901 taaatatgtc gtcagctttc tcaaggaggc gaaaaaatcg ttcatcatgc cgcgattttt 3267961 tccgtctgtt ccctttccca agaaccgttt ggcgggctgt tctaagcatg agcaccgtct 3268021 gatgctgtgc gttatgaaaa cctggcgttc cgacggctga aagacatgca gccagctgat 3268081 gatatgtttt ttgcagcacc gctccctccg gtccatgttt gttccataac cagccgatta 3268141 aagcgatacc catggcgaaa atgccgccga gaaacgtcag tcccgctctg aacagcgctt 3268201 gtgaaggatc ggccggcagc ccggaactga ctaaaaaggc aaggacaaaa aacatcggcg 3268261 cagggccttg aatgccgagc gcgctaaaaa taaacatcgc cgctgcaccg atcagcccca 3268321 aaacagccgc catcatccaa agcatcccgg acaaaagcgt ccctaaacca aatgagaggg 3268381 cgatcccaat agaaaccaag agcagcttca aggcgcgctt tttgtacgat tcaccgcccg 3268441 catataaata aacaaagcct ccgatacttg caattaatcc gtaatccgtg tgacctgcca 3268501 atgcaccgac cagcacagga aaccctgaag cgaaacctga tccgatagcc tttttccaag 3268561 gaaatggatt tgcatgaatg cgaaaggcat ccttcacgat aggcatgatt ctttgattgt 3268621 tcgcagcagt tttgttcatt tgacaaaatc cttttcaatg aatgtgtaga acttttccag 3268681 tttcttcgct ttagtatgcc caaaaacgcg gttagcttct caattggtgc gcacgataaa 3268741 aaaacagaga cttataccgt ctctgcttca ttacatcagt ttattataaa agcggcacct 3268801 gtcaggactg ttttgtcctt ctgccttcct tcaagagcag gtgaataaaa aataaaggat 3268861 aaatcaatag atacccatta aacagccacc acacaagatc aaagtcactg ctgaatgtcc 3268921 agaatgatag cgcctgcaga cctgaacaac aggtcagcac aagagaaatc agcgccatca 3268981 gcttccagtc agcacgattc acccgctgta ggtacaagct gtacaaccct gtgacagaaa 3269041 tcaggatatc cagcggaaaa aaagaccagt tccaagcgat cataaacgga tggtcatgat 3269101 gtttaaaagc ccagctttcc ggtatgagcg aaaatccggc tgacagccag tacaagataa 3269161 aaccgatatc agtcacgaga aaaaacagct tcatatatct catttgtact gcccgctttt 3269221 atgtaccggc tcagacaccg caacatgctc gatcaggttt aaagacacaa caccggcaat 3269281 aatcaatcca attgaaatga ctttcatgac actcacatgt tcttgaaaaa acaaaaaacc 3269341 aacgactgta atcaagacaa ttcccatccc tgaccataca gcataagcaa ctgatacatc 3269401 aatggattta agcgtaagcg tcagaaagaa aagactccct ccataaaaga aaatcaacag 3269461 caaactggga ataagctttg taaaaccaga cgatagcttc atgctgacag ttcccgcaac 3269521 ctcaaacaaa atcgccaagc atagaaacac ccaattcatg tggcatcagc ctcctcatca 3269581 gctgttatac cgttaaacaa aacatctaca attgattcaa gtacctctcc tgtcgtgaac 3269641 tgatgtttca gcggatattc agggtcatac acttgattga tgctccctat atacatgtga 3269701 acaaacaggt ccggattgat gtttctgatt ctcttttgct gtttgcactc atttaataat 3269761 gctaggacaa tcgcccattc ttccttaata aacgcgtcta atgtaagcca cgcatcgtaa 3269821 tggtatttct ttagttcatt taataatccc atgttcagca gttccatccc ctgcggaagg 3269881 ctgatcagca tttgtttcac cttttcgagc acatttaaac tttcattttc atagatgtct 3269941 ctttctattt gcttcatttc agctataaat tgttcgacaa ccgcctcaac aagctgatct 3270001 ttagatgaat aatatgcata gagcgtccgc ttgctcgttc ccagcgctgc cgccaaatca 3270061 ttcatcgtaa atgaaaatcc tttctgcttg atcagccgga aggtttccgc cagaattctt 3270121 ttatccatat taatcccccg ctttcggtac caagaaaact atttcggtac caatattata 3270181 cggcagaaat ttatggaaat caacaatata taaaaaaacc tctcctattg ggagaggttt 3270241 aaaagacact gcggaccaaa ccgccgtccg cccgaagtgc cgcgccattg atcgcagagg 3270301 aaagcggact gcttaaaaat gtaacgaagt gggcgatttc ttccggacgg atcagtcttt 3270361 gaataataga tgtcggccgg ttttctttca taaaacgtgc ctcagcttct tgaacagtca 3270421 ggttttcacc aggatacagc gagttcagca tggtttccac accctctgtt aaggtagagc 3270481 ccggcatgac ggtgttgact gtgacattcg tgccggttgc cagctccgcc aaactgcggg 3270541 aaatggacag ctgcatcgtt tttgtcgcac tgtaatgggc catttcctgt gacggcataa 3270601 tcgccgcttc actggcaatg aaaatcacac gcccttcttt tttctctatc atgttatgca 3270661 aatacctgcg tgtcagcctt acaccgctca taatattcac ttcaaaaaaa cgaaaccatt 3270721 catcgtcggg aatatcaaag tactccgccg gttcaaaaat ccctaaattg ttgaccaaaa 3270781 tatcaacctc tggatatgcc tgaaacagct cattgcagcc ttcttctgtt cccaaatcaa 3270841 atgcagccgg ataaagaacc gcttcagcat gttgtgtttt cagttcatct atcgtttgat 3270901 tcactttctc ttcccggcgt ccgttaatga tcactgccgc accttcttca gctaacgaag 3270961 aggcaatagc ttttccgatc cctgatgtcg aaccggtcac cagtgcggtt tttccttgta 3271021 aattcagctt cattattcat ccctccgttt ttgattcctc ttatttattg acagaaatct 3271081 gattggtgaa acatctgctc tgcaatcagt atgaaacagc tgggattgaa atggaagtac 3271141 gcactttttg gtgcctgtgg tttggagaaa aaataaagca gaacctctta agaggttctg 3271201 ctttattgtc agtatgtatg gagacggtgg gagtcgaacc cacgtccaga aacatcgatt 3271261 acttaagcgt ctacgagcgt agcctgcata tttatggttt cactcatctt cttgcctgcg 3271321 ggcgggcctt ccgagagcta gtctgttcat ctcttcttac gttctcagac gggaacgcaa 3271381 gcgtagccta cttggatgtg ctcttcacag acacataggc aatgtcagga agagctcgct 3271441 gcgcttatta ggcagctaat gctacgtttt ggttaaaact gttagttttg ccagttatat 3271501 ttaagtgcgt gtttacgaga tcgcctctcg gctcgcagct caagctcgat ccatccctgt 3271561 cgaatccgta acgtcccctt ggtataaggg aaatacggga gaaaatatca agctctcact 3271621 caaactggct atagtcttat tataacatga tcacggctct tttcaattgt caaatccttc 3271681 aaatgaatgg cgtcgtgatc tgatcgtgaa cacagtatag cacaggcctg attttcgaat 3271741 caagcactat gcctttagaa gcctttttga ctgtctctga acgctctttc gatttcccgc 3271801 ttcgcgtcct tgcgcttcag atcttcccgt ttgtcatagt tcttcttccc ttttccaagg 3271861 ccgagaagca ctttggcaaa gccgtttttt aaatacagct tcagcggaac gagagaatag 3271921 cctttttcct ttgttaaccc gatcagctta ttaatctcct tgcggtgcat taacagcttt 3271981 cttgtccgga gcggatcgtg gttatagcgg tttccctgct catatgggct gacgtgcata 3272041 ttgtggagaa acacttctcc ccgttcgatt ttggcgaagg aatccttaag gtttacgcgg 3272101 ccggcgcgaa tcgatttgat ttcggttcct tgcagaacga tgcctgtttc ataggtttct 3272161 tctataaaat aatcgtggtt ggctttctta ttttgagata atacttttcc tgaccctttt 3272221 ggcatgccag aacctcctct ctctaaggaa aaactgtcca ccttttgcga tacgctctat 3272281 tttaccaaat gtcacgtacc gctacaatga aaagctgttt ccgaaagaaa gcaaatagag 3272341 cgctgcggcc ctatttgctg gttgagctgc tatttcttct ttttccgttt ctgtttcgga 3272401 gcattctgga agccgcgttt tttctttttc ttcttcggct tagtgaacca ctcccctttt 3272461 tcctcagacg gagctggaga aacaggtgta ttggtgcttt gaacacgttt tctggcaggc 3272521 tttccgcgtt ttctgctccg gctgctgtcc aattctctcg gacgccgcgg agtgcctttc 3272581 atgccgacaa tttcaaagtc gatattgcgc tcatctttat tgacatcgac aaccttgact 3272641 gtgatttcat ccccgatgcg gaagacgttg cctgtccgct cgccaatcat tgcgaaatgc 3272701 tgttcgtcaa agcggtagta gtcatctgtc ataaagctga catggacgag tccttcaatt 3272761 gtattcggca gctcgacgaa cattccgaag tttgtcacag agctgatcat gccgtcaaac 3272821 tcttcaccga ttttatcaag catgtattcc gcttttttca gatcatccgt ctcacgctcg 3272881 gcgtcaactg cacggcgctc catagatgat gtatgttcgg cgatatccgg caggcgttca 3272941 gcccactttt cctgtgtcgc ttcatcgacc ttgccgttga tcaaatacgt tcggatcaga 3273001 cggtgaacga ttaagtccgg gtaacggcgg atcggtgatg tgaaatgcgt atagaattcc 3273061 gttgacagac cgaagtgccc caagctttgc gggtcgtatt tcgcctgttt catcgaacgg 3273121 agcataacag tagatataac cgtttcctct ggtctgtcac gcacagcgtc cagaatgctt 3273181 tgcagcgcgc gcggatgaat attccccgcc gttcctttca ccacatagcc aaatgtcgtc 3273241 acaaattcta aaaacttttg cagcttttca gcattcggct cttcgtgaat ccggtatata 3273301 aacgggacat tcatccaatg gaaatgctcc gcaactgttt cgtttgctac aagcataaat 3273361 tcttcaatca gcttctcggc gacagagcgt tctctgatca caacgtcttt aaccgctcct 3273421 tcgtcatcaa caagcacctt tgcttctttg aaatcaaagt caacggcgcc gcggtccatc 3273481 cgcttatcgc gcagaatttg agccagacgc tccatgtctt tgaacatcgg aacaagaggc 3273541 tcgtattttt gtttcagctc ttcatcatca tcaacaagaa ttttattcac atctgaatat 3273601 gtcattcttt ccgttgtttt gatgacactt tggaagatct cgtgctctgt cacctgtccc 3273661 tgactgttaa ttgtcatttc acaagaaagc gtcaggcggt caacctttgg atttaaggag 3273721 cagatgccgt ttgacaatct gtgcggaatc atcgggatga cacggtcaac cagatacaca 3273781 cttgtccctc tttcaagcgc ttctttgtca atcggcgagt tttcggttac gtaatggctg 3273841 acatcagcta tgtgaacgcc aagcttgtag cttccatcat caagcttcgt cacggtaact 3273901 gcatcatcca aatccttcgc atccgcacca tcaatggtga caatcacctg gtcacggaga 3273961 tcacggcggt ctttcagatc tttttcatca atcgtgtcag gcgtacttga tgcctgttcc 3274021 atcgcgtcag ctggaaattc tcccggcagg ccgtgcttat gaatgaccga taaaatatca 3274081 atgcccgggt cgtttttgtg gccgagaatg gtttcaacct caccctctgc gttcatgcgg 3274141 ccttcaggat agctcgtcag cttgacaaca accttatgcc cttccgcagc tccatttttc 3274201 ccatttttcg gaatgaagat gtcactcgtg atttttttgt cgtccggaat gacaaagccg 3274261 aagtttctcg tttctgtata cgtgccgaca acccgctgaa tcgctctttc taaaatccgt 3274321 atgacggttc cttcctgcct ggagccgctt gattgtgagt tcagacgcac catgacgata 3274381 tcgccgttca ttgccgtatt tagctcatta ggcggaataa acacatcact taacgacgta 3274441 tcctcaggca gcaaaaaggc gaatcctttc gcatgggctg aaatctttcc ttttattaaa 3274501 ttcatcttct ccggaatgcc gtagcggtcg cttctcgtcc gtacgataag ccctttttct 3274561 tccaaggcga ctaacgcttt gacgagctct ttaaactcct cggcttccgt aatatttaac 3274621 atctcctcaa gttcctgaac ggtcagaggt ttgtacgcct cttccttcat aaacgagaga 3274681 agcttttcca taaatgcttc tttttccatt atccgacctc ctgttgatta ccaatcgagc 3274741 ttctctaaaa attcatacac atcctgatgg acgaggtcac gttctttgtc gagtgtaatg 3274801 acatgccctg attcctcgta ccatttcagc tgtttatcat cagtttccac ttcgttgtaa 3274861 ataatattgg cgctttcggt attaatcatg tggtcatgac gggcctgcac cacaaatgtc 3274921 ggtgaataaa tcatatcgac attattccgc acatcagcaa ttaagtcttg cagcgccttg 3274981 agggtattca tcggcgtttt ttcgaattct ttcatttcct cttcaatttg ctccgggctt 3275041 ttcccctcaa actttttgta attgcgagcg tatgaaagaa cgccttgata catgacctct 3275101 tcactcttaa tatgcatcgg tgcgcacatt gggacaattc cctttatggg tacagtgtaa 3275161 cccaatttca gcgaaaaaac cccgccaagc gacagtccgc aggcagcaat gctctcataa 3275221 ccttcagatt ttaaatattc atagccatcc attacgtttt tccaccagtc ttcgggcccc 3275281 gtatgtacaa gttcttcagg cgggacgcca tgtccttcat attgaggcgc gtggcacgta 3275341 tagccgcgtt cattcaaata tcgtcccagc atccttacat ccgctgtatt tcctgtaaag 3275401 ccatgcagca aaagcaccgc tttgtctccg cctttaaatg taaatggttt tggtgtcaca 3275461 actttcatgc tcatgtctcc ctttctatct gcacgatcat tttagttttc cacagtttaa 3275521 tcagaaaaaa acgttttgaa tatcatccag aaacgtgaaa aaggcctgac ttcacatcag 3275581 accttataca aacattgccc tataggatat aagcaagcgc aatcgttaac acgaaaaaca 3275641 agactgccag cactaccgta atgcggtgca aaattaaatc aagacctctt gctttttgtt 3275701 tcccgaagag ctgctccgct ccgcctgaaa tcgcaccaga taatccggca cttttactgg 3275761 attgaagcaa aacgacaata ataagtgcaa tgctgacgat aaccaataag gtaatcaaaa 3275821 ctgcgtgcat cccatacacc tccagactca ctggctacat tacttctatt ttacatgaaa 3275881 agggttggca tgtcacgctg tatcagacgc caaaaggccg gataagacgt tttatcttgg 3275941 ttaccctatt catatgaaaa ggtcaaagga gaaaagcgat gccgcttatc agcatagaca 3276001 gcaggaaaca tcttttttat gaagaatatg gacagggaat ccctatcatt tttatccacc 3276061 cgccgggcat gggacgaaag gttttttatt atcagcgcct tctatccaag catttcaggg 3276121 tgatttttcc ggatttaagt ggccacggtg atagtgatca catcgatcag ccagcgtcta 3276181 tttcctatta cgcaaacgag atcgcgcaat tcatggacgc tttgcacatt gataaagctg 3276241 tgttattcgg gtattctgcc ggaggcttaa tcgcgcagca tatcggcttc acccgcccgg 3276301 acaaagtgtc acaccttatt ctgtccggcg cctaccccgc tgttcataac gtaatcggcc 3276361 agaagctgca caaactggga atgtatctgc ttgaaaaaaa ccccggtttg ctcatgaaaa 3276421 tcctcgctgg cagccacaca aaagacagac agcttcgcag catattaaca gaccatatga 3276481 aaaaagcaga ccaggcccat tggcatcagt attatctgga ttcgcttggc tacaactgca 3276541 ttgaacagct gccccgccta gaaatgccaa tgctgtttat gtatggcggc ctgcgggact 3276601 ggacctttac aaacgcaggc tattaccgaa gatcgtgcag acatgccgaa tttttcagat 3276661 tggaatatca gggacatcaa ttgccgacaa aacaatggaa aacgtgcaat gagctggtga 3276721 cagggtttgt gctgacacat cattcatagg aatagaaaac gcttggcttc cttgcgtttt 3276781 ttgttacttt attgactttt gtcaacgaaa tcatagtaaa aaagatcctc aaatttcaaa 3276841 ttaaaatagt gaagcatttt accaatcaca agctgccccg gccttctttc tccattcagc 3276901 acgcggctca gtgtggcggg tgagactccg atttccagcg caagctgatt aagggaataa 3276961 tcgttattaa ccatatactg caagacataa tcacgtctaa tctgtatctt ttctactggc 3277021 actttcctca ccttccattc ctgaaaaact tttttctata cttttacatt acggcttatg 3277081 ttaacttttg tcaatacatt tccagtctac ctattccctt tagtcaataa acatactaaa 3277141 atatgagtaa cagtgaggga cggggtgaga tatatggaaa gctttggcga acaattacgg 3277201 gcattgcgtg aagagagaaa gttaacagtc aaccagctgg cgacttattc aggcgtaagc 3277261 gcggccggca tctccagaat cgaaaacgga aaacggggcg ttcccaaacc tgccaccatc 3277321 aaaaaactgg cagaggcctt aaaaattcct tatgaggggc ttatgtacaa ggctggttac 3277381 atcgaagaag tgcatgaagc cagggcccct tatgaaacga agtgcaagct gcttgaaaaa 3277441 gcggaggcct atgacctgaa aaaccttgcg cttcttgaga acgaaaagtg gcaatatctc 3277501 aataaagaag atttgctcat gctggatcat tatttttcgt ttatttcaga tgaagcgaaa 3277561 aaacggtctg ctgatgactg actcttgata gaaatgtgag gcgatagacc atgtcaccgt 3277621 tcggacagca attacgggag ctgcgccgcg cccgcaaact gacagtgaat cagcttgcgg 3277681 tgtactcagg catcagctcg gccaccattt caaaaattga aaacggcaaa cgcgggacgc 3277741 caaaacccgc cacgattaaa aaactggcag ccgtcctgaa agtgccgtac gaaaacctaa 3277801 tggccgccgc aggccatatt caggcctttc ctgaagaaat ccgcgaagca tctgaaggct 3277861 atcaatccgt ttatgaaatt taccagacgg ctgtcacacg cggagcggag cacctcccga 3277921 ttttcaatag tcaaaaatgg gaacatctct caaagcagga tattgaaaat ctcagcaaat 3277981 acttcgattt tttgtcttca gaagcaaaaa aacgcgcctc ttcctcataa tcccctgttt 3278041 ctctttctat attttatcaa tcacgcttgc atgccctccc tcgttatttg cgttataata 3278101 gtgacagacg aggtgaaaag tatgaaccaa tcagaaatgt gtcctagatt tgaaaaagca 3278161 gtcgacatct taagtaaacg ctgggtcgct ttaatcgtat ttcagctctt gaacgggtcg 3278221 cagcgattta gcgaaattga agcagcactt ccaaatctaa gcggcagagt tctgtcagaa 3278281 cggctgaaag aacttgagct tgaaggagta gtgaagcggg atgtcatccc tgaaactccg 3278341 gttcgcatcg aatattcatt gactgataaa ggaaaggcac tagcacccat attaggtgag 3278401 atttctaaat gggcgactga atggattgac ccttcctttc ttgactaatt gctaaaatgg 3278461 ttctgatctc aaagacgaga aaagaaccgt tttttatttt ccaggtgaaa aaaagatatc 3278521 tcagccgata tatagtacat ccacacatta cgtttttaaa ggagaccact atatgcgact 3278581 gacgatttcc cgcaaattca gcctggtatt tttgacactg atcctgatca atttacttgt 3278641 aggcggaata ggcgttctta atatgcagca tatcattcaa aaaacagatg aaatcaacac 3278701 aaaatggatt gacggcatca aaggaatcac ttcaattaat tatgtaaccg agcacctgtc 3278761 ttctaaagaa aaggactttc tgatttatac agacaaaagt aaaatggata cacttgatca 3278821 agaaatgaat caaatcatgg aagacattaa ccaaaagctc gataactacg aaaaaacgat 3278881 ctccactgat aaagagcaga aactgttcga gcagcttcaa actaaagtga atacctatat 3278941 ggatattcat gcgcaaatta tcgaaagcgg ccgcacgaat gacatggaca aagcaagagg 3279001 tttattggtt cagactgagg ccagctttga ggatatgaaa aaaacaatca ctcagcttgt 3279061 tgacttaaat caagaaggca gcaacacagc ggtaaaagaa acgaaggccg tctatcataa 3279121 agggctcatt tacactgctt tgcttgtggc agcatcaatc ctcatcagca ttttcatctg 3279181 gctttatatc acgcgaaaca ttgtaaagcc tatcattcgc atgaaggaat ctgccaatca 3279241 tattgccgaa ggcgatttgt cgaacgatat ggaggccctc aactcaaaag acgagctggg 3279301 tgatctgaat gaagcgctgc aaaaaatggt agggaatctg agagatattg tcggatattc 3279361 taaagacata tcaagccggg ttctttcttc ttcacaggtg cttgcaaccg caacgaatga 3279421 aacaagatcc ggcagcaaac atattaccga gacgatgaac gaaatggctg agggctctga 3279481 acagcaggcc caagacgcgg tgacgattgc cgaatcgatg aatgagttta ccgaaagcat 3279541 tgataaagcc tataatcacg gcatcacaat cagcgatacg tctcaaaacg ttctcgaact 3279601 cgcggtaagc gggaacgaaa atatggctac gtcattacag caaatgaaaa ccatccatca 3279661 tattgttgaa gaagccgtgc ataaagtgag atcactggaa cagcattctc aggatattaa 3279721 caagctcgtt caggtcatca acgggattgc cgagcagacg aatttgctgt cccttaacgc 3279781 cgcgattgaa gctgcccgcg ctggagaaag cggcaaaggc ttcgccgttg tggcagagga 3279841 ggtcagaaag ctggctgacg gcgtttctga ttccgtgcag gacattaccc ggattgtaaa 3279901 cgggacacag caggagatcc acactgtcat tacgtacttg gaaagcagct ttacagaagt 3279961 cgaaaaagga acggaaaacc tgacagacac cggacaggct atgcagcata tcaaacaatc 3280021 cgtcacccat gttgcagaca gcattaagga agtaacggat ggcttgaagc agttaacaaa 3280081 ccaatcgatt accatcaatc aatcgattga aaatatcgct tctgtatccg aagagtctgc 3280141 cgccggcatt gaagaaacat tttcaattac cgagcaatcc gcccattcga tggatcaagt 3280201 gcttctaaat gctgaagagc ttgagcagct ggccaatgag cttaatgaga agatgggtca 3280261 gtttacgatt taaagagaaa aaagaggctg gactccagcc tctttttcta ttctatgcag 3280321 ctgattgaac atgtttcgcc ccggttcttt ttttcttcac cggacttaat gcccgctcca 3280381 gccaagccat gagcaaatcc gcccctaccg ccatcaccgc agttggtatc gctccggcta 3280441 gaataatcgc agttccgttt gttgcgtttg agccgcgtac gatcatgtcc ccaaggcctc 3280501 cggcaccgac aaatgtgccg atcgctgtaa ttccgatggc aatgacgaga gccgtgcgaa 3280561 ggcccgccat aatgacagaa agtgcgagcg ggagctcaac cattctgagc acttggaatt 3280621 tcgtcatgcc cattgctttt ccagattcta agtaggcatg ttcaatactg ataatgcctg 3280681 tgtacgtgtt tcgaataatc ggcagcaggg aatacagaaa taatgataga atcacggtat 3280741 ttgcgccgag ccccataaca agcattaaga cggccagcat agcgagcgcc gggattgttt 3280801 gaataacgtt tgttacggca aacacccagg ctgacaaacg gcgaaaatgc gcgatgagga 3280861 ttccggccgg aaccccgacg acagcggcaa ataaaacgcc gtaagccgac atgagaaagt 3280921 ggcggccgaa ttcatccatg acgtaactgc cattctgcgc gtaatacgtc attaactgtt 3280981 caagcacgtt cattgacctc ttcccccttt cacgattcga aatagcgatg tttttctaaa 3281041 tattccttgg caacgacaga cggttctttg agattgccgt cgacttcata gttaagctcc 3281101 tgcatcgtgg ctgtgtcgat ttttccgagc attttcttga tgatgccttc aagttcagga 3281161 tgttctttga gcaccttttc cggaacaacc ggagagcagt cgtacggcgg gaaaaattgt 3281221 ttatcatcct ttagcatttt gagaccatag gacttgattc ttccatcggt tgaatacgca 3281281 agcacaatgt ccatttttcc gcttttcacc gcgtcgtaca caaggccgat ctgcatcgga 3281341 tacgtgccgc cgaatgtcat gccgtaggtt ttcgtaaaat cctgatagcc gtttcctttg 3281401 agcttcatcc aatagttatc aacgcccagc tttaattgcg gcgcccattt tttaacgtct 3281461 gatacggtct ctaaatggta ttggtcggcc agctccttgc tgactgtaaa ggcatatgta 3281521 ttatcaaacc cgtaggagtc ataccacttt aaatcatatc tttttttaaa ctcccgctga 3281581 gtaagcgcca gcgctttgtc cggatctttt tcaggttcca ttctcaacgt gcctgtcagc 3281641 gcgtctcccg tatatcttgt ggccgcaatg tcgatttccc cgttcattaa agcctgctgc 3281701 tgcaccgcgt tggagccaag atttttaatc gttgttgttt tgagatcagt atggtgttcg 3281761 atcaactggc caagcatgct ggcgatgatt tctgattcgc tcatgctttg cgcgccgatt 3281821 ttaatggtct ggtctgcagc agcgctgaga ccaggaagcg aacagccgct cagcgtcagc 3281881 gttgccgcaa gtgctaaacc tatcattaat ttgagatatt ttcttttcat gagccgcctc 3281941 cttatgacaa ttccttcaat ctctgcatgc cggcaggtgt cagttttcgt tcagcaactg 3282001 ccagcacata atcaatcaca attgccaata tcgtgacagg taccgcgccc ccgatgatat 3282061 attccggctg atataaattc agtccgataa aaatgtaatc acccaatccg ccgcctccga 3282121 taaaggaagc aagcgtggcc cagccgatta agtaaatcgt cgatgttctg attcccgcca 3282181 tgatcactgg tgcggcaagc ggcagctcca ccaagcggac ttgttcagcc ggcgtcattc 3282241 ctattccttt accagactcg agcagatttt tgttgacgcc gcgaatgccg gtatacgtgt 3282301 tgcgaagaat cggcaatacg gaatagaaaa acaaagccac aatggccgga accttcccta 3282361 caccaaggag cgggataaaa aaagcgagga tggccagact cggcagcgtc tgaatgatat 3282421 tgacaatgcc gataatggtg ccggctcctt ttttcattct ggtaagcaca accccgaggg 3282481 ggacggcaac cagcacacct aagatcacag caatgagcga tatcgtaata tgctcgtatg 3282541 ttttataaag aagctctccc ccattggttt gcaaaaattg aacaatatga tgcatgactt 3282601 atcgcccctc cctatgacaa tgctgcgagc tgcttttctt ctccccagag ggagtcatac 3282661 acgatgtcga ccagacttgc cctcgtcaca attccgatca ggcgtcggtc ttcatccaca 3282721 acgggaacat atttgacacc ccgttttaaa attttgcgga ccgtgtcgcg cagcagtgtg 3282781 ccgcccagta ctgtgtatat atcttcatgt aaaacttcac tgacgagatt ggcctttttc 3282841 cggcattgat caatgatttc aacatcgaca tagccttgca gaacgcgctc gtcattgacg 3282901 accagcaatg aatcgacccg ttcctgcctc atcagctgaa tggcctcaga aagcgtttta 3282961 tccgcggtga tcgttacagg ctgtgtgttc ataatctggt caacccgttc aacatccggg 3283021 ctggatgact gaatcagccg ctccttgccg ataaattcct caacaaattc gtctgccgga 3283081 tttcttaaaa tgtcatcggg cgttccaact tgaacgattt ctcccgcttt taaaatcaca 3283141 atccggtctg ccagcttaat cgcttcatcc atatcgtggg taacaaatac gatggtttta 3283201 tgtaaggttt tttgcagttt tttaaattct tcctggaggg aatccctcgt aatcgggtcg 3283261 agtgccccaa acggttcatc cattaagata agcggcggct ccgcggcaag tgcccgtaat 3283321 acaccaattc gctgctgctg ccccccgctt aattcatgag ggtaacggtc tacatattct 3283381 ggccccatat cgaccaattt taaaagctca cgcgcccgct ctttccgctg ctgctccggc 3283441 catttcagca gttttgggac gagtgagata ttctgctgaa tggtcatatg gggaaacagg 3283501 ccgatctgct gaatcacata gccaattttg cgcctgagct ctacaggatc ctggtccatg 3283561 atgttttcgc cgtcaatgaa aatcttcccg gcggaaggct caattaatcg gttaatcatt 3283621 ttcattgttg tcgtttttcc gcagccgctc ggcccgataa agcagataaa ttcgcctttt 3283681 gcaatcttaa gatttacgtt gttcacggct tttttgccgc ccttgtatgt tttcgagaca 3283741 ttttctaatg tcagcaaaca tcgcacctcc aaaattaagt ttattcaatt tgttcagttt 3283801 aaatttaatt tttcagacaa ttgaatgctt cccattatag aataaagttt ataaaataaa 3283861 aagtttacaa tttgttcata ttatttataa agtatgtgta aacgctgatt tacccgcatt 3283921 gacgtgtgtt gatctcctta ttgctccaat ttcctgccaa attctctttt gacagcattt 3283981 tcgccgtatc aaaaatgtgg tatattgaca tcggaattgt tagctgaaag gatgaaaccg 3284041 ttggagaaag atccgttaac gatcattgaa caagccgagg accattttat agaaagaatc 3284101 gcggaaaaca tgcatgcatt tggaatgccc tctaccgtcg gacgagtgct gggcattatt 3284161 tatatgaatc gaaaaccgat gacgcttacg gaattatctg aggccaccgg catgagtaaa 3284221 acacgtatga gccaggtagt gcgggaaatg cttgatgcca acattgccga gaaggtattc 3284281 gaaaaaggcg tgcgaaaaga tttatatgag gttgagcagg actactatca aacatttatc 3284341 acgctgtttt cagccacctg gagcaaagtc gtcagcaaaa acaaaatgat gcataaaaaa 3284401 ctcaatcggg agctgcttag cgtgttggat gaagagctta ctcctgaagc ggaagaaaaa 3284461 gtgaatgagc tgctgaagga attaaaggaa tggctcgatt attataattg gctcagccgt 3284521 ttgattgagt tttttgagag cgaagacatt tttaaatatg tgccgaagcc gtaaaaagtt 3284581 cccaaattca attctgggaa cttttttaag tccaatccaa atggttgaat atcaaacttc 3284641 aagaaaacaa acaaaataat gcataattta cattaattta ttaattatcc attttttgtt 3284701 gattattctg actagctatt atataatctt tttgaaatga ttatattagc ttagaggagg 3284761 taatctacat caaaaaaaag ggaattatta ctgtaatgac tatatgtttc ctattatttt 3284821 cttcttatta ctttagcaat atttcacctc agaatccact gttcaaaaaa aattttttgc 3284881 aacaattgtc tccccaaggc tttggctttt atagtaaaag ccctacagaa gaaaacattt 3284941 catttcacac aaaagaaaat ttaaagttac ctaatgcact tcccaataat ttttttggga 3285001 taaaaagaga aggaagagtt caggcaatag aattaggcaa aattgtagag aatatcgatc 3285061 caaagaattg gaaaacttgt gaaaacaaca actcctgcac aaatttagag aaacaaataa 3285121 agcctattaa ggttataaaa aatgaagatt atatacatct tagcaaagga gaatacctaa 3285181 tatatcgcca aaaaccactc tcatggtatt ggatagactt taagcaaact acctcttttg 3285241 aaagaaaggt gctaaaaata aaaatagtat gaagatatta aatagtttag aaggttatat 3285301 tgacacctat aatccatgga aaaatacata tgcacttttt agaagtttac ttggtttctc 3285361 aacattacta gtactattat tcaatagtac tgatatttta tttagttata gtgcaaataa 3285421 tgtcacatgt gaaaatgtct atatccctac cgctttttgt tttgctaaag aatatagtat 3285481 caattttgag attataagat acttaatgat ttttatatta accttagtgg ttatagggtg 3285541 gagacctaga tttaccggtt tatttcactg gtatatttgc tatagtattc aaacttcagc 3285601 tttaactatc gatggtggag agcaaattgc aactgttctt tcttttctta tattacctgt 3285661 tacattatta gattcaaggc gaaatcattg gaatataaag aaaaacaata atgaatcttt 3285721 cacaaagaag acagtattgt tttatataat gacaataatt aaaattcaag tttttatcat 3285781 ttatttaaac gcagctttag agcgattgaa aaataaagag tgggcagaag gaacagcaat 3285841 ttactatttc ttttctgatc cggtgtttgg attacctgaa tatcaactta acttaatgaa 3285901 tccactactt gaaagcaatt ttattgttgt catcacttgg ttagtaacta tttttgagtt 3285961 gttcttagca gcaagcataa tttcaaatat cagaataaag agaattgccc ttgttttggg 3286021 aatattattt catattggga taatattcag cattggtatt gtaagttttg gcttgatcat 3286081 gatatcagca ttaattatat atctgcatcc tgtacaacaa aatatcacta tgaattggtg 3286141 ttctccttta tttaaatata tatatgtaaa aggaaagaga aatttcaaaa gaataggagg 3286201 tgaatcagtc aagtttctta caaaattgtt tcatagctaa catttagata atggagaaat 3286261 aacttaatgg aggtataata atttgaaaag taaattactt aggctattga ttgtttccat 3286321 ggtaacgata ttggtttttt cattagtagg actctctaag gagtcaagta catctgctaa 3286381 agaaaaccat acattttctg gagaagatta ctttagagga cttttatttg gacaagggga 3286441 agttggtaaa ttaatttcaa acgatttgga ccctaaactc gtaaaagagg caaatagtac 3286501 agaaggtaaa aagttagtaa atgatgtagt caaatttata aaaaaagatc aaccacaata 3286561 tatggatgaa ttgaaacaat cgattgacag caaagaccct aaaaaactca ttgaaaatat 3286621 gaccaaagca gaccaactta tccaaaaata tgctaagaaa aatgaaaacg taaaatactc 3286681 ttctaataaa gttactccat cttgtgggct ttatgccgtc tgtgtagcag ctggatattt 3286741 atatgttgtg ggcgttaacg cagttgcatt acaaacggct gccgcagtaa caactgcagt 3286801 gtggaaatac gttgccaaat attcctcttc agcttctaat aattctgatt tagaagcggc 3286861 tgctgcaaaa accctaaaat tgattcatca ataatccatt ataattgagt gtcttgcgga 3286921 ttgctccgca agacactttt tcaacgtgaa ccgtttaatt ttttgtaata atgatatgaa 3286981 gctagtgttg aaataactaa tgctagaaga actagcacaa tcataataag aattatatat 3287041 tctcctgtaa aaaatgaaag aacagctatt ataaaaccac acactacaag tactttagag 3287101 gcaaagcgat ttcccagttt ccaaacagtc tcatctttta atgtccaagg tgtcctcaat 3287161 ccaataagat ggttttgttc tgctagctgc atagaatttc caccaataat taaaaagata 3287221 ccaacaccaa gccctattat taaatcaata ttcacttcgt atcctaaact tatcaataga 3287281 gttgagagtt gtaaaatata taaaaggatt aacatattat tagaagctag gaaaagcaat 3287341 gctttatttt tttgtgtaga cttaatagtt aacatataaa aagtaagata ataaataagc 3287401 ataacaacag gtataataaa tattgttaaa ggtttagata caattgcagc cggtttattt 3287461 cctgaccatt gtatcggtat ttcttctgga aggtattgat ataatataat tgaagtcaag 3287521 aaactcaaac atacaataat tatggaaatt atatttttct tcataaatcg ttatcccctt 3287581 tatttataaa gttaagcatc caatttattg agtcttgaag tactgttgta tttagagagt 3287641 aataaataaa ttgtcctttg cgatggtcac ttatgacttc cgcttgcttt aaaatattca 3287701 agtggtgcga aatactcggt ttgctgatat taaaatgctc agcaatatct cccgcagtca 3287761 tatcccctcc ttttaacaaa tccaaaattt ttctccttgt tggatctgat atagctttga 3287821 aaacattatt catagcgttt tctcctttac aaaaaaacat ttagacattt agatatttgt 3287881 ataaatgtat tattttcatt ataacttgaa tttttttaaa aacaaccctc aaattggtta 3287941 taatatctga tttttgtatt ttttcaaata ctcggataat cccaacgctg gaaaatatgt 3288001 ttaacagata ctaacacatg ttgtttattt aaaaaaacca cctctgttgt atttaaatag 3288061 aggtggtttt tctatcagct ataataaaat ttcctttttt ctttttaatc gggcttaatg 3288121 ctcgttcaag ccagcccatg accaaatcgg caatcaccgc catcagagct gtggggatcg 3288181 ctcccgctaa tataatcgcg gttccgtttg tggcgtttga tcctctgacg atgatgtccc 3288241 cgagaccgcc agcaccgaca aatgtcccga tggccgtaat gccgatcgca atgacaagcg 3288301 cggtgcgcag gccggccatt atgacagaaa gcgcaagcgg aagctcgacc atccgcagca 3288361 cttgaaattt tgtcatcccc attgcttttc ccgattcaag ataggcgtgc tcaatactga 3288421 taatccctgt atacgtattt ctgataatcg gcagaagaga atacagaaat aatgacaata 3288481 tcaccgtatt agcgcccagc cccatgacaa gcatcagcac ggcgagcatg gcgagagccg 3288541 ggatggtctg aatgacattc gtgaccgcaa aaacccatcc gcttaatctt ctgtatctgg 3288601 ctatcaggat gccgagcgga attccaacaa tggcggcaaa taaaacgcca tacaccgaca 3288661 tcagaaaatg gcggtaaaat tcctgcagca cgtaaccgcc gttttgcgaa tagtatgtgc 3288721 caagctgctg tagtacttcc atatgatcca cctcttttct tagtcaaaat aatgatgttt 3288781 ctctaaaaat tcctttgcta cgacagacgg ctccttcagc ttgccatcca cctcataatt 3288841 aagttcctgc atcgtttccg tgtcgatttg cccaatcagc ttattgatca caccttcaag 3288901 ttccggatgc tccttaagca ccttttccgg aatcaccggt gaacagtcat acggcggaaa 3288961 gaaacgctta tcgtctttta agattttcag atcatatgct ttaatccgtc catccgttga 3289021 ataagccaaa accgcatcca ttttcccgtt tttgactgcg tcatagacta gcccgatctg 3289081 cattggataa gttgtgccga actcaaagcc atatgtgctg acaaagcctt tatacccgtc 3289141 gccttttcgt ttcagccaag cattgtcgac gcctaattta tattgggaag catttttctt 3289201 caggtcagac acggtgttaa tatgctcctt ttccgcaaac ttttttgtta cggtgaaggc 3289261 atatgtgtta tcaaagccgt aggaatcaaa ccatttataa gaaaagcgct tttgaaactc 3289321 gttctgcaca atgttcagcg cttttttcgg atctttctcc gcttccttgc cgagggtgct 3289381 tgttaaatct gttccggaat agcgcgtggc tgaaatatca atgtcaccgc ccagcatcgc 3289441 ttggtgctga acatagtttg agccgaggtt tttcactaaa gcagtattca aatctgtatc 3289501 atgttcaata agctgcgcga tcatattcgc tacaatttct gattctgtca tgctctgcgc 3289561 cccgattttg atcgtatcgt cagaagcgcc gcctagaccc ggcagagagc agccgcctag 3289621 cagcatgaca aagacgagag caaacgcgcc aagccatttg atttttgtca ttttcaacag 3289681 tgccaactcc ttacgatact tccttcatcc cttgcaagcc tttcggcgtc acctttcgtt 3289741 ctgtcacagc cagaacataa tcaataataa ttgccagaat tgtgacaggc acggcaccgc 3289801 caatgatata ttcaggctgg tataggttca gtccgataaa aatatagtcc ccgaggccgc 3289861 ctcccccgat aaacgacgca agtgtcgccc agccaattag gtagatcgtt gatgtgcgga 3289921 tccccgccat gatgatggga atcgccagcg ggatttcaac gagccgaatc tgctcccagc 3289981 cggtcatgcc aattcctttc cccgattcca ggaggttttt atttacacct ttaatgccgg 3290041 tatacgtatt gcgcaggatc ggcagtaccg aatagaaaaa taaagcgaca atcgcaggca 3290101 cttttcctac gccgagaagc ggaataaaaa aggctaaaat cgccagactc ggcagggttt 3290161 gcacaatgtt tacgaaaccg ataaccgcac ctgcgccttt tttcattctg gtaagagcaa 3290221 cgccgagcgg cactgcaacg ataatgccca atacaacggc tatgagtgaa atatataaat 3290281 gctctcctgt tttatacagc agctctccgc cgttcgtttg caaaaaagtc atcatttgat 3290341 tcatcttaaa agagctcctc ccctggtcag atcgtcatga gctggttttc ctcgtcgccc 3290401 caaatggaat cgtatacgat atcaacgagg ctcgctcttg tcacaatccc tgctaaatgg 3290461 ttctgttcat cgaccaccgg aacatacttg atcccctgct tcaaaatttt tcggactgta 3290521 tcgcgaagaa gcgccccttt ttgaacggta tatatatctg aacggtatac atcgccaacg 3290581 atgctcgctt ttttgcggtt ttgatcaatc atttccacat caacatagcc cttcagcacg 3290641 ttttgccggt ccacaacgag cagcgagtca acacgttttt ctctcatcag ctgaatcgcc 3290701 tgagaaagcg ttttgtccgc agataccgtc accggcgttc tgttcatcat ttgctctacc 3290761 cgctcgatat ccggtcttga ctgaatcagg cgctctttcc cgataaattc ttcaacaaac 3290821 tcatttgccg ggtttcgaag aatctcatca ggtgtgccga cttgaacgat ttctcccgct 3290881 tttaatatca caatcctgtc agcaagctta atcgcttcat ccatatcgtg ggttacaaac 3290941 acaatcgttt tgtttaaggt tctctgcagt tttttgaatt cttcctgaag ggaatcacgc 3291001 gtaatcggat caagcgctcc gaacggttca tccattaaaa tgagaggggg ttccgctgcc 3291061 agggcgcgca gcacgccgat tctctgctgc tgtccgccgc tgagctcatg cggataacgg 3291121 tctaaatact ctgggcccat atccacaagc tttaacagct cgcgcgcccg ttctttccgt 3291181 ttttcctcag gccatttcag cagctttggt acgagtgaga tgttctgctg gatggtcata 3291241 tgggggaaca aaccaatctg ctgtatcaca tagccgattt ttctcctcag ctcaaccggg 3291301 tcctgttcca taatattttc tccgtcgata aagatccttc cagacgatgg ttctatcagt 3291361 ctgttgatca tcttcatcgt cgtcgttttt ccgcagccgc tcgggccgat aaaacagata 3291421 aattcacctt ttgcaatatc taaatcaatg ctgttcacag cttttttgcc gcctttatat 3291481 acttttgaca cttgttccaa tttcagcaat ccgtgcacct ccgcaggttt cctttaaatt 3291541 ttctgaaaag tataatcctt attatagttt gaactttgta aaataaaaag tttacaatgt 3291601 gttgaaatta tatgttattt atagattatt tattgttatg accgagacgg aaagggtgtt 3291661 cttacaatta ctccggatac ctcccacttc ctctgcattc agctattttc aacaccagga 3291721 agaaatatga tatattgaca ccatcaattg ccatttgaag ggatgatcag ctgtgaaaaa 3291781 aaccgctctc gacatcattg aacatgctga agagcatctc attgagaaga ttgccgaaaa 3291841 tatgcatacg tttggaatgc cttcaactgt cggacgtgtg ctcggaatta tttatatgaa 3291901 tcgaaaacca atgaccttaa gcgagctctc tgaggcaacg ggcatgagca aaacacggat 3291961 gagccaggtt gtccgggaaa tgatcgatgc caatatcgcc gaaaaggtgt ttgaaaaagg 3292021 cgtacgaaaa gacctttatg acgtcgagca ggattattat caaaccttca tttctttatt 3292081 tgcggcgaat tggacaaagg tcgtgagcaa aaacaaagtg ctgtataaaa aattaaaccg 3292141 ggagctgagt gatcttttac aaagggacgg gcttaccccg gaagcggaag agaaagtcaa 3292201 tcagctgctg aatgaattaa aagaatggct tcattactat gattggctga gcaggttgat 3292261 tgaatttttt gagagtgagg aagtctttcg gtatgtgccg aaaacaaaag aatgcagctc 3292321 tctaaaataa gagagctgct ttttgcatca tgaagttaag accggaaaca tgcctttcag 3292381 cccggcacca atcatcccga ccgcaaccac ggctaagatt aatcccatca gtctggtaat 3292441 cacattcatc tcggtttttc cgagtttgct gctgataaaa gcagaatagt ggaaaaagag 3292501 aaaggtcagg gcaataacgg cggctatgcc gatcatgaca gccgcataat gaccaatgcc 3292561 gctatgtccg gcggaaaggc tcatcactgt tgcaatcgtt ccgggcccag caatgatcgg 3292621 aatggataaa ggtgtgactg atatatccgc tttttccttg ctttccttat gttcatcatg 3292681 gtgaagagat tgcacgtgcg attctttcgc attcaataga ttataggcaa tgccgaaaat 3292741 gaatatgccg cccgccactc ggagcgcgtg aatgttgata tcaaacagtt taaagataag 3292801 atgaccgaaa accaaaaaag ctgcgagaat aaaaaaggat aaaatagctg ccttccgggc 3292861 aatcgctttt ctttccgctg cagtatagcc ttctgtcagc gtcagaaata tcggtacgtt 3292921 tccgatcgga ttcgatactg cgaataaaga aatgaagacg tgaacgataa atgagaacat 3292981 catatacctc cttgttgata gtctctgcac aggaaataga atgattctcc acccttttac 3293041 ccggaggcga tttcccggta aacctttata gcctgtcaga aacgcgccat gctacaatga 3293101 agtgacaaat tgaataggaa ggacgtatac agatgttcaa aaaaattgcg gcagatgcct 3293161 tgggcttatc tgatatcgga aaaattatcg aacctcagga ctatgacaaa acagacgcag 3293221 atgactatgt catgcatgaa gataatgaga aaatttattt cttgattaaa acaaaagcag 3293281 acgagtattg ctttacgaac ctggccctga tccatgtgga cggcgaacgc gccacttcct 3293341 caaaacgaac gttgaaacgc tatccttatt cgcaatataa aatctctgac gtttttcttg 3293401 aaactgccgg aaaagtggat ttggatgttg aaattaagtt caagctgggc ggtgaacaat 3293461 tcgacattga tgtccacaaa gaccagattg aaaagttaaa agacctttat aaagcactgc 3293521 ttcgcatcgc tgaaacaacc tatgaaaatg acattttaat caatcaagcg gagcaaagct 3293581 tagataaagc agtgacgatt cttcaccata cccgccctga gcacgtcaat attgaaacgc 3293641 aatacaaaga gctgaccgaa ttcggattca cttggctgac atccgttcgc tcgcagtatc 3293701 atattaagga ttttggggat gtatttgaga aatatattaa taactagata aaaaaagaca 3293761 cagctgctat cgtgctcgtg tctttttttg tatgaatatt gattacttta caactttttt 3293821 cttttataat aaaactatta gtctattttc cctatattac agataaagga gttattttat 3293881 gtattgtcct caatgcggcc atcaaacaga tggcggaaat ttttgtgaga aatgcggatc 3293941 accgctcccc ggtcaatcag gccaccagca tgcagctcaa actggagccg ctgcaaagca 3294001 agcagcaaaa cagttcggtt catttgtctt atccgtcctg aaacgccctt atcaggaatg 3294061 taaagcaaca ggcggagaac agctgatcag cgcaatcatt acgatggttc ttttcagttt 3294121 gctgacccct ttgatgtttt atattctttt ttcagacggt cccggaagcg taagctttac 3294181 agcaatcttc ttagagccaa ccatttattt tattttattt ctatttggcc tgcatgcatg 3294241 catctttttc gccctgaaaa tcgcgggaaa ccaagtgtct ttcaaggatt cattctcaag 3294301 attcggagca tttcttattc cttttacggc tattttgatt cttgcccttt tcttcttttt 3294361 attacataca gacatttgct ttaccatatt agccgttggt ttaatcggtg cattcttcgc 3294421 cattcctcct gcgatgctga gcagttacca gcattcatat aaagggaagg ttgatttcat 3294481 ttactcaacg attgtgattt atctgatcat ctgcgttaca tttcagctta ttatcgaaca 3294541 ctatgtcaaa gaaattttcc gttatatgct cttttaaaaa caaccccatc acctgctggt 3294601 gatggggttg ttttattgaa tagacgttaa gtaaattctt ccgttcttca ctacgccggt 3294661 gtaggtccag ttatatgttc tgagctttgg actgccgcct gattttgtga tatagaattc 3294721 ttcatacgtc ttaatcgtga tagccgaccc attttggctc cagcttttca cttcatagtt 3294781 attaaagtct tctgttgtcc cctctttatt taatttcgac acgagatgct gctggtcgga 3294841 ataaagggaa ctgccttttt caaggctgtc ttccatcagt gagaaattat tttgattcac 3294901 ggcatctgcc tgactttgca gataactgcc cataaataat gtcacttgtt catctgtaac 3294961 atcgccgctt gcagagcttt cactgccttt gtttttcgag ccagcccagg cggaagtgta 3295021 tgtctctggt ttatcatttt tgattttctt tatatttgtg cctgcagatt cgaatgttga 3295081 ttctgcatct tcgaaaatcc actttttctg ttttttatca tatgaaagaa gatattcata 3295141 actcggactg tcgtcagtca tttcagactt tgtatagtcg ttatacgaag aagactggtg 3295201 aagttctttt cctgttaccg atacctgcca cgttccgtcg tttttctgag agagggcaaa 3295261 tgtgtccagg tcaaaatcag tttccaagta tctatctttt aagtatgaat ccgcgctttt 3295321 catagaatcg acggtgtcct tcgtctccgc cttccaattg gcacttgcct ctgtcatctg 3295381 ggctgtattc ccatcagata gagctttgga gtattgtttt gttgttttga caattgtgtt 3295441 cataatctgt tcctgtgtat cttgatcagg aattaacgtt aactccattt ctttatcatc 3295501 gatcggaacg ccggcagttt ttgtttttcc ccacggaaat tctgcctcga ctgaagctgt 3295561 cattgatcca tctgtcagca gcggaccata tgttacggat ttgaacggat ctttatgaat 3295621 tgatttaccg ttaatcagca aatctccctt cccgctcttg atgtcattcg ctaagctgaa 3295681 tgtcacatcg tctgcttcca atgagagatc aacacgaaag ctgctatcgc caatcgcctg 3295741 aatgtcttcc tttttcacaa ggtcaacgac atcgtttttc agtttggctg agactgtata 3295801 ttcgccggga atgtacggac caagggtttg tgcttgatct gctttcttta cagatccggc 3295861 ttcctcttta ttgacatata gatcggtatt tttataattg ctgctcactt caaaataaac 3295921 aggtgctacc tttaagtcat aatggtcaaa taccagcagg cttttcccgt ctttttccgc 3295981 atatacgata tccttctggg ctgtttcatc acgcagcgat gcaaaaagtt catctttttt 3296041 gtctggatga tccttcaaat atgtaagaaa cggttttaca ttatttttag tgagtttaag 3296101 attgtcattt accggtgtaa gcagagtcgc gatttggtcc tgatccccat catttacggc 3296161 ctgttcaaac ttgtctacta acctatcctt tgaagtaaaa tacgctccgg ttttatatgc 3296221 ggcgaataat ataacgcacg ccgcggcaat gctgctccat aaaatgatgg ttttcttagg 3296281 gatcggtttt cgcggagcct gcctcgtttc tgcagtgcta gctgtttctt gatttgcctg 3296341 tttgctgccc cctccgatcg gggtgccgca ttgtttacaa aacttggctc cttcattatt 3296401 ctgggagccg caattcttac aaaataacat gactttcctc ctattctact aatttgataa 3296461 catttactgc ttttcatatt ttataataaa acagaatgaa attgggaacg aatgaaaaaa 3296521 ttaaatgtct atcagactaa aaaggtggaa tgaatatgca aaagctcagg attgaattag 3296581 gagaagaaac aaatgacgaa ttatatgatc tattgctgct cgccgatcca tcgaaagaca 3296641 ttgtagatga atatcttgag aggggagaat gttacacagc ttgggccggt gatgagcttg 3296701 caggggttta tgtattgcta aaaacaaggc cgcaaacagt tgaaattgta aatattgcgg 3296761 taaaagaatc tcttcagaag aaaggctttg gcaaacagct tgtacttgac gccatcgaaa 3296821 aagcgaagaa gctgggggcg gacacgattg aaatcggaac ggggaattcg agcattcatc 3296881 agctttccct ctatcaaaaa tgcggattcc gcattcaggc gatcgaccac gatttctttc 3296941 tcagacatta tgatgaggac atttttgaaa acgggattca atgccgcgat atggtaaggc 3297001 tttatttgga tctctgaaag cataaaaaag ccgccgagag aaaatcccgg cggtcttttt 3297061 attacttgtt taagttgtag aaagagttga taccgtggta ttgagcagtt tcagccaact 3297121 gatcttcgat gcgaagaagc tggttgtatt tcgcaacacg gtccgtacga gacggagcac 3297181 ctgttttgat ttgtcctgcg tttgttgcca cagcgatgtc agcgattgtg ctgtcttcag 3297241 tttcaccaga acggtgagag ataacagctg tgtagcctgc gcgtttcgcc atttcgatcg 3297301 catcgaatgt ttcagtcaat gtaccgattt ggtttacttt gatcaggata gagttgccta 3297361 cgccgttttt aataccttca gaaagttttt tcgtgtttgt aacgaagagg tcgtcaccaa 3297421 caagctgaac ttttttgcca agacgctcag taagaagctt gtggccttcc cagtcgtttt 3297481 cgtcaagtcc gtcttcgatc gagatgattg ggtatttaga aacaagctct tcataccagt 3297541 caaccatttc agcagatgtt ttcacaacgc cttcgccaga cagatggtat ttgccgtctt 3297601 ctttgttgta gaactcagaa gatgcagcat ccatagcaag tttaacttct tcgccaggtt 3297661 tgaagccggc tttttcgatt gcttcaacga ttgtttgaag cgcttcttcg ttagaaccaa 3297721 ggtttggagc gaatccgcct tcgtcaccta cagcagtgtt taagcctttt gcgcttaata 3297781 ctgatttcag gctgtggaag atttgagcgc ccatgcgaag tgcttcacgg aagttaggag 3297841 cacctacagg catgatcatg aattcttgaa tatccacgtt gttatcagca tgctctccgc 3297901 cgtttacgat gttcatcatc ggtacaggaa gcgtttttga gttgaatcct ccaaggtatt 3297961 ggtaaagagg aatctgtaag aaatcagcag cagcacgcgc acaagccata gatacgccaa 3298021 ggattgcgtt cgcaccaagt ttgcctttgt tttcagtacc gtcaagctcg attaaaagct 3298081 gatcgattgc gttttgttca gttacatcaa agccaagaag ctctggagca atgatttcgt 3298141 ttacgttgtt aacagctgtt aacacgcctt ttccaaggta acggtctttg tcgccgtcac 3298201 gaagctcaac cgcttcgtat tcacctgtag aagctccgct tggcactaat gcgcggccga 3298261 aagctcctgt ttctgtatat acttcaactt caactgttgg gttgccgcgg gagtctaata 3298321 cttcgcgtgc ataaacatca acaatgtatg gcatgagttt tgtctctcct tttgattttc 3298381 aaattatttt tgaattaaag atgttcctgt catttctttc ggtttttcaa caccaagaag 3298441 gtctaataac gttggtgcaa ggtcgcctag gattccgcct tcacgcagcg taatgccttc 3298501 tttcgttaca atcacaggga ctgggtttgt tgtatgcgca gtgtgcggtt cgcctgattc 3298561 tgtaatcaga atgtcagcat taccgtgatc agcggtaatg atagcgtgtc cgcctttagc 3298621 aaggatcgcg tcaacgactt cgcccaagca ttcgtccact gcttcaattg ctttaattgt 3298681 tggttcaacc attccggagt ggccgaccat atcagggttt gcgaagttaa gaatgatcgc 3298741 gtcatgcttg tcagcttcaa tttctttgac aagcgcgtct ttcacttcat acgcactcat 3298801 ctcaggcttc aagtcatacg ttgcaacttt aggcgagttg atgagaatac gctcttcacc 3298861 cgggaattca gcttcacggc cgccgctcat aaagaacgtg acgtgcggat acttttcagt 3298921 ttctgcaatt cgaagctgtt ttaacccgtg ctgagataat acttctccga ctgtgttatc 3298981 aagatttatc ggtttaaacg ctacatagcc gtcaactgtt tcactgaagt gagtcaggca 3299041 gacgaaatac aggttctttg gataattctc gccgcggtcg aagtcacgga agtctttgtt 3299101 tgtgaacgtg ttggaaatct ggatggcgcg gtccggtctg aaattataga aaatcacaga 3299161 atcgccgtct tggattttcg caacaggctc accgttttct tttgtgatga cagatggaat 3299221 cacgaattca tcgtagatac catttgcata tgaatcatca acaacatcca gggcgctgcg 3299281 gtaagatggg ccttcgccgt acgccattgc gcggtacgct ttttctacac ggtcccagcg 3299341 tttgtcgcgg tccatagagt agtaacgtcc ggaaatgctg gcgatttcac ctacaccgat 3299401 ttccttgatt tgatcgttca actggttgat gtacgttttc gctgtctgcg gacctacatc 3299461 acggccgtca aggaagccat ggatataaac ctttgtcagc ccttcttttt tcgcaagctt 3299521 taacagtgcg aataaatgat tgatatggct gtgcacgcct ccgtcagata aaagaccgaa 3299581 caggtgcaag gctttgttgt tttctttcgc gttgctgatc gcgtcaagga atgtttgatt 3299641 gcgttcgaac tctccttcac gaatggcaac atttacgcgt gttaagcttt ggtacacaat 3299701 acgtcccgca ccgatattta agtgacctac ttcggagttc cccatttgcc cttcaggaag 3299761 acctacagcc tcgcctgaag cagtcaaagt ttgatgagga tactggttcc aatagcggtc 3299821 aaaattcggt tttttcgcta aagcgactgc gttccctact gtttcgttac gtaatccgaa 3299881 cccatcaaga atgatgagtg cagctggttt tttactcata ttgaccttcc tccaataatt 3299941 gaacgaatga ctgtggctca aggctcgcgc cgccgaccaa agcaccgtca atatcggact 3300001 ctgccatata ttctttaatg tttgcaggct ttacgcttcc gccatattgg atgcgaagct 3300061 tgtctgcagc ttcttggctg aagctttcag cgacggtttt acggatatgc gcacacacgt 3300121 cattcgcatc tttcgctgta gaagatttgc ctgttccgat tgcccagatt ggctcatacg 3300181 caataacaga agcagcaact tgttcttcag aaagaccagc aaggcctttt ttcacttggt 3300241 cagcaacaag atcatttgtt ttgccggctt cacgctcttc aagcgtttca cctacacaga 3300301 tgatcggcac aatgccgtgt ttgaaagctg cgtgtgcttt tttgttaact gtttcatcag 3300361 tttcagcgaa catttcacgg cgctcagagt ggccgatgac gcagtagtca acgccaaggt 3300421 ctttcagagc aaccgggctg atttcgcctg tgaacgcgcc gctttcttcg aagtgcatgt 3300481 tttgagcgcc gacttttagg tcagtgcctt tcacagcaga agcaagcttt tctaagaaaa 3300541 gcgctggcgc gcaaacaaca gcttcagctt tgtctgctgc tggaatggaa gatttcactt 3300601 cttcaacgaa gctgacagct tcgccgagtg ttttgttcat tttccagtta ccggcgataa 3300661 ttggttttct catctgttcc acttccttat agcagttttg agattattta tcgttcagtg 3300721 cagctacccc tggaagctct ttgccttcca taaactcaag ggatgcgccg ccgcctgttg 3300781 agatgtggct cattttgtca gcaaggccga atttttcaac cgctgccgca gagtctcctc 3300841 cgccgatgac agagtatgta tctttcgcct ctgccaatgc ttccgcaacc gcttttgttc 3300901 cttgagcgaa caagtcgatt tcgaatacgc ccattggtcc gttccacacg acaagtttgc 3300961 tgtttttgat gacgtcagca tacgtttcgc gtgttttcgt accaatgtcg attgcttcta 3301021 aatcactagg gatttcagag atcggcacaa ttttcacgtt tgcatcgtta gagaaatcat 3301081 ctgcaacgag tacatcttca ggcatgtaga agttaacgcc tttttcttta gcgcggtcca 3301141 taaatgattt cgcaagctcg attttatcct cttcaagaag agatttcccg acttcatagc 3301201 caagcgcttt tacgaaagta taagcaagac ctccgccgat gatcaggttg tctactttat 3301261 caagaagact ttcgattaca ccgattttgt cttttacttt cgctccgccg atgatcgctg 3301321 tgaacgggcg gtcaggattg gaaaccgctt ttccaagtac atcaagctct ttttccatta 3301381 agaaacctgc aactgctggc agatgctcgg caattccagc tgtagatgcg tgagcacggt 3301441 gggcagcacc gaatgcgtca tttacatata catctgcaag ctcagcaaat gcttttgcaa 3301501 gctcaggatc atttttctct tcaccaggat agaaacgtac gttttccaat acaagaacgt 3301561 ctccgtcctt catctcagaa atttgtgctt ttacagcatc gccgtatgct tcatccgctt 3301621 ttttcacttc tttgccaagc agttcgccga gacgtgcagc gacaggagtt aaacgaagct 3301681 cctcaaccac ttcgcctttc gggcggccta agtggctcgc aagaaggact tttgcgcctt 3301741 ggtctgcaag gtgtttgatt gttggaagcg cagcacggat acgtgtatcg tctgttactt 3301801 ccccgtcttt cattggaacg ttaaagtcaa cgcggcagaa tacaactttg ccttttacgt 3301861 cgatgtcttt gagagttttt ttattcatgc ctaggagatc ctccttcaaa atggtttgca 3301921 tacagcacga aaaacgtgaa accgtctgtt caagcgataa ctccgctagg gcagatcgca 3301981 gtctttttcg gcacagggca gttcgtctaa aagccagggc agcggcctta ggcgaaagcg 3302041 ccggcaaagc tgcttaaaac gcggtcgttt ctctatcaca gagcgttttc tgaaagccgg 3302101 tcttcatgga aaaagggaaa gggagtccgt ccccttccct tgtccgcttt cattatagcg 3302161 cttctattcg aaagaaccaa gtcaggtcct ttttcagcta taaattaaag accttttttt 3302221 gcgatgtaag ctgcaaggtc aacaacgcgg ttagagtagc cgctttcgtt atcgtaccaa 3302281 gagattactt ttaccatgct gccttccata accattgtag aaagagcatc gattgtagaa 3302341 gagtttttgt ttccgttgta gtcgccagaa actaatggct cttcgctgta gccaaggatt 3302401 cctttaaggt cgccttcagc cgcttcttta agagctgcgt ttacttcttc agctgttact 3302461 tcttggttca gttcagcaac caagtcaact agagaaacgt ttggagttgg aacacgcatt 3302521 gctccaccgt tcagtttgcc ttttagttca ggaagaacta gagaaactgc tttagcagca 3302581 ccagttgatg ttgggatgat gttttcagct gctgcacgcg cacgacggta gtctttgtgc 3302641 ggaagatcaa ggatttgctg atcgtttgtg taagagtgaa cagttgtcat cataccgcgt 3302701 ttgatgccga atttatcgtt aagtactttt gcaaacggcg caaggcagtt tgttgtgcaa 3302761 gatgcgttag agataacatc gtggttagcc gcatcgtatt tatcttcgtt aacacccata 3302821 acgattgtga tatcttcttc gttagcagga gcagagatga ttactttttt cgcgccagct 3302881 tctaagtgtt tcgcagcgtc tgcgcgtttt gtgaagaaac cagtagattc aactacgatt 3302941 tcaacgcctt gtttgcccca gctaagttta gcaggatcgc gttctgcaga aacttcaatt 3303001 gttttgccgt taacaacaag gttgttaccg tcaactgaaa cttcagcgtc taattttccg 3303061 tgtacagaat catattgtaa aaggtgagcc agcatgttag catctgttaa atcgttaacc 3303121 gctactacct caacttcagg attgtttaat gctgcgcgga atacgttacg tccaatacga 3303181 ccaaaaccgt taataccgac ttttactgcc atgattgttt cctcctttaa ataagtgaga 3303241 gatatttata ttgagggatt attcatccct taataacttc tttgcggctc cttcgtctgt 3303301 gacgagaacc gtgttgcgtg gctttttaaa gtaagcctcg atcgcttcgg cttttgatga 3303361 tccgcccgct accgcaataa tatcggggat ggcgtctatg tcatccagct gcattccgac 3303421 agaatgcact ttgtgaacca cttcgccgtc cgcgttaaaa tagtagccga acgcttccgt 3303481 caccgcgtcg ttatcatcta ttttctttaa atcttctaaa ggcgtgtttc tgcgctgagc 3303541 catagtttta gcttcgccga ttccgtgaac cagcatactc gctgatttaa tggtgttcag 3303601 cacctctttg acagaaggct cttcaataat agatgaatag gcgccttgtg acagctgtcc 3303661 cggaacaaac aaaagccggt aagtgcctga agccttctcc gccatatgcg cgcatatggt 3303721 gttcgcctgg tttttcacgt cttcgcctaa accgcctctt gcaggcacaa acaaaagctc 3303781 gcggttttta gaatccggcg tcatcatttc ggcgacagct tcaattgtcg taccgccagt 3303841 tacagcgacg atatttttgc ctgaaaatct ttttttcata catgcgacag ccgctcttcc 3303901 catttctttt ttgacccatg gggattgatc gctgtctccg gatacgataa tggcatcctt 3303961 tagatttaaa cgttctttta atgtcttttc caaaagagtc aaacctaaaa catctttcat 3304021 cgtatcttcc aaaacagaaa gcagttcata gccctcttct gtcaatgtca tgccgtttgt 3304081 cttaatatcg accaggttct gttcctttaa aaactgaacc tcgcccctca gcacacgctc 3304141 gctgattccg agactggcag acaggcttct tcgcccgatg ggttctgtca gcctgatata 3304201 ctgcaagatt tcaaacctct tttgcataac gagcagaaga tcaggcaata attttttttg 3304261 agcttgtatt aactggttca tgactcaaac gttccttcct tttttgctgg acattatatg 3304321 tcccgctatg acaaaaaacg tcccgtcata gccaaaaaaa atcatttctg ctttctttaa 3304381 ttattttaac agggtggaat tgtttattca actgttaaga gccaattcat cgacaatatt 3304441 cgcagagttt tcatgccgcg tcgttttatc cagcaatatt ttatcctata tatctttatc 3304501 ttatacagaa agcgccaaat ggtgcatccc aatataaaca gcccttcccg tagaaagggc 3304561 tgtttcatta aagcgttttc attttatcca aagcttttca atttcctcga gcgatttgtt 3304621 cttcgtttct ggacagatcg taacgacaaa caggaaacaa aggatgttaa tcaccgcaaa 3304681 gatccaaaat gtataggcga gcccgaaaga atcgatcatc attggcacaa actgtccgat 3304741 cgcccagttt gctccccata aaaagatggt cgcaatgccc gcggcccgcg cacgcagatg 3304801 gttcgggaag atttcagaaa tcataatcca tgtgatcggt ccgaccgaga cacagaaagc 3304861 agcgacaaaa cctaatataa ggacgatcat catgatcccg cttgttaact caaaataaaa 3304921 cgacgtcccg attaaaatca taaaaatagc cataaaagca gaaccgatgg acatcagttt 3304981 ttttcgtccg actttatcaa tcagcaacac cgcaataacg gtaaaaataa cttctacaac 3305041 cccgacgata caagtcgtca caaatccggc gttttgcccg aatcccatca ttttaaagat 3305101 ttccggcccg tagtaagtaa tcgcgttcat gccgatgact tggttaaaca gcgccagcag 3305161 gattccaatg acaagcgcct ttctgagacc cggcttaaac agctgggaga gcgaccccat 3305221 ttgttctatt tttaaagagt tctcaatgtt ctttaattct tcttttgcaa cagtttctcc 3305281 attaatacgt gtcaggatct ttaaagcttc atttgttttg cccgctttcg ccagccatct 3305341 cggactttcc gggacgacga gcaggacaag gaaaaaaatg acggatggca ccattccata 3305401 agcaagcatc catctccagc cggtgtgcac gccccattcg tatgttccgg accgctgcac 3305461 agctagatta ataaagtatg ttgcggaaat acccagtatc gtaaagagct gatataacga 3305521 agataaactt ccgcgtatag cgggcggtgc cgcttctgta atatacgtaa cagagagcga 3305581 tgagcccatc ccgattccca gccccccgat aatccttgca atgattaagg tggacacgtc 3305641 ttgagaaagc gctgaaacga ttgctgatat cgcaaataac aaagcggctg tcattaaaat 3305701 ttttctccgg ccgaatctgt cacttaaaaa tccggatatc ccgacgccca caactcctcc 3305761 aatcataatg cttgaaatga caagtccctc cataaacgga ctcaggctgt ataaatcttt 3305821 cagaaaaccg atggcgccag aaatcactgc cgtgtcatag ccatacaata agccgccaag 3305881 ccccgccgca catgagatca aaatgacaaa tcccattgaa tggcttcttg ttacaggaac 3305941 atttggttct aattgagttg gagtattctt catttccctg ccctcccgaa tgttgagtaa 3306001 agcgttttca tttaaacctt caattgtacg tacttatatt aaaatttaac gaaaattaca 3306061 tttaattagt acgtacaaat atagaataat cttgtttgca ttttctgtca atgttttctt 3306121 acaaagaacg ctgtgatata ctgaaatttg tccgtataca ttttggagga atggatatgt 3306181 taccaaaata cgcgcaagta aaagaagaaa tcagttcttg gattaatcaa ggcaaaatac 3306241 tgcccgatca aaaaatccct accgaaaacg aattaatgca gcaattcggc gtcagccggc 3306301 ataccatccg caaagcgatc ggagacctcg tatcacaagg tctgctgtac agcgtgcaag 3306361 gcggaggcac ctttgtcgct tcacgctctg ctaagtcagc gctgcattcc aataaaacga 3306421 tcggtgtttt gacaacttac atatcagact atattttccc gagcatcatc agaggaatcg 3306481 agtcctattt aagcgagcag gggtattcta tgcttttgac aagcacaaac aacaacccgg 3306541 acaatgaaag aagaggctta gaaaacctgc tgtcccagca tattgacgga ctcatcgtag 3306601 aaccgacaaa aagcgccctt caaaccccaa acatcggcta ttatctgaac ttggagaaaa 3306661 acggcattcc ttttgcgatg attaacgcgt catatgccga gcttgccgcg ccaagtttta 3306721 ccttggatga tgtgaaaggc gggatgatgg cggcggagca tttgctttct ctcggccaca 3306781 cgcatatgat gggtattttt aaagctgatg acacacaagg cgtgaaacgg atgaacggat 3306841 ttatacaggc gcaccgggag cgtgagttgt ttccttctcc ggatatgatc gtgacattta 3306901 caacggaaga aaaagaatca aaacttctgg agaaagtaaa agccacactg gagaaaaaca 3306961 gcaagcacat gccgacagcc attctttgtt ataacgatga aattgcgctg aaggtgattg 3307021 atatgctgag ggagatggat cttaaagtgc cggaggatat gtctattgtc gggtacgatg 3307081 attcacattt cgcccaaatc tcagaagtga aactaacctc tgtcaaacat ccgaaatcag 3307141 tgcttggaaa agcagccgcc aaatatgtca ttgactgctt agagcataaa aagccgaagc 3307201 aagaggatgt catatttgag cctgagttga tcattcgcca gtccgcacga aaactgaatg 3307261 aataaaaaaa gcaatgtatg ggtctccccg ctacattgct ttttttatag ctgttatctg 3307321 tttttccaaa cgtcagcgat gatttcaaac gaacgcattc tgtctgcgtg ttcaaaggtt 3307381 tctgagttaa ccataatttc gtcagcctgt gtcgttttga cgaaatcttc aagcttcgcc 3307441 ttcacttctt ccggacctcc gacaatcgtg gagctcagct gctcattgac catcgctttt 3307501 tcatacgggc tccagatttg gtccatatcc tcaacaggcg gtttaagctg gttaggcgta 3307561 ccgcggacaa gatcaagaaa cctttgataa tgggaagtcg caaggtgctg cgctttctcg 3307621 tttgtatctg ccgcgataat ggtgacaccg accatcgcat acggttcgtc gagcacgtct 3307681 gacggcgtga aggaattgcg gtacagctcc aaagcgggaa ccgtattcgc cggtgagaaa 3307741 tgggccgcga acgcaaacgg aagaccaagt tcgccagcca gacgggcgct gaagccgctt 3307801 gagcccagca gccaaatcgg cacatctatg ccctctccgg gaatggcgcg aacttgattg 3307861 cgcacatttc ctgacggttt aaaataattg cgcagttcct ctaattgttc tggaaaatcc 3307921 tccccgctgt tgatgtttct gcggagcgct ctggctgtca attggtctgt tcccggcgca 3307981 cgtccaagcc ccagatcaat ccgcccggga tacagtgttt ccagtgtgcc gaattgttca 3308041 gcaatgacta atgaagagtg gttggggagc ataatgccgc cggaaccgac gcggattttc 3308101 ttcgtgcctc cggcaatatg gccaatcaaa actgcggtgg cagagcttgc aacaccttct 3308161 atattatgat gttcagcaag ccagtaacgg tgatagcccc attcctctgc ccggcgcgcc 3308221 aagtccatgc tgtttcggaa tgattctgca atcgttcctc cctgaacaac cggagataaa 3308281 ttcaagacag aaagcaaggt atctttgcgt tggttgttag acatattgtt ctcctttgca 3308341 aatgtgttat cagtaaacag cccaaagctg tcaggtcatg attgaaagaa cttctatcac 3308401 accataacac aactgcattc aggaataaaa gaatttgatt cgatgaaatt cgaacaatat 3308461 aaaacgaacg gtttggaaca ttattctgct ccaaacaact ccttagccat ctcaataaag 3308521 agcttagccg ccagagaagc ctcctttagc gacggaacag caagctgcac atcacggtat 3308581 acctgcgggt ccaattccct ggtcaccaca tgctctggca gcggcatccc cgacatggac 3308641 atttctgata aaatggccag gcccaggcct tctctgatca tactgatcga ggtgttgatg 3308701 ttatagaccg tgaaagctgg gtgcagcgta gcacccgcct gcctgaacat atcgataaat 3308761 ggtgattcat agccgccgtc acagacgatc atcggttcat ggtcaagatc tttcagcgta 3308821 atggctgaat gactggcaag cgggtgatcg tccctgagca cgacagccat tttgtctttt 3308881 ttcaaatgaa tgtactccat ctcctctgtt ggatacagaa gaatcccaac atctatcatc 3308941 cgcgtatgaa gccactcctt gacttcattt acagttccct cgtgcagcac gagctcaagt 3309001 ttcggatatt tttgtttaaa ttcactgatc agcttcggca taaaataagc cgaggcagtt 3309061 gagaatgtgc cgatatggat cgttcccagt tcaagccctt tttccgctgc tgctacctgc 3309121 tcaacttttt caatgccttt taagacttct ctgatgtgta ctaagatctg ttttcccgta 3309181 tccgtcagca tcaggccatt gcggcggtca cgaatgatca gctttacatc aagctcagct 3309241 tcgatcgcag aaatcgcatg gctgacagcc ggctgtgtca tgttcagcgc ctgacccgct 3309301 tttgtaaagc ttcccgtttc agctattttc acaaaaacct ttaattgagt aatggtcata 3309361 acaatttact tatgctcctt ataaaaaaga ttcattttat ttatcttatg ttctaccgta 3309421 tcatatgatg gaaaagttct acaaggagtg aatgaacaat gaagcagctc ccaaaaacgc 3309481 ggacagctct cctgctcgca tttctcgtca tcatgtgggg cgtcaattgg ccgctgtcca 3309541 aagccgcgct cgcctattct ccgccattat tgttcgcggg catccgaacg ctgatcggcg 3309601 ggcttttatt agtcatagtc gcactgccgc gtattcataa attacgctta aaagaaacgt 3309661 ggccgattta tcttgtttct gctcttttaa atattacatt attctacggc ctgcaaacga 3309721 tcgggctgaa ttatcttccg gccggcctgt tttctgcaat cgtcttcttc cagcctgttc 3309781 tgatgggtgt attttcttgg ctgtggctcg gcgaatccat gtttgtaatg aaagtgattg 3309841 gcctcatcct cggttttgcg ggagtagccg tcattagtgc tgcgggcttt ggcgggcata 3309901 tttctgtcat tggggttctg ctggctctcg gctccgcagt cagctgggcg ctcgggacag 3309961 tatatatgaa aaaaacaggc agccgcgtcg attccatctg gatggtcgct ctgcagctga 3310021 cgatcggaag cgtgtttctg cttatctccg gcttttggac agaaagcttt tcggcgatcc 3310081 aatggacagc tccgtttatt acgagcctgc tgttcatctc cgtattcgtt atcgcactcg 3310141 gctggcttgt cttttttacg cttgtcggtt caggagaagc aagcaaggtc gcatcttata 3310201 cttttttgat tccgctcata tcaatcgtgg ccagctccat tttcctgcat gaaccgctca 3310261 cccttagcct cttggcaggg ctgctgctga ttgtcacgag catctgtctc gtgaatacaa 3310321 aatcaaaagc gcagaaagct gcggcgattg gtataaacga gaaagctgca caataataaa 3310381 aaccctcttg ccggatgcgg caagagggtt tcttatttac tgatgcttgc gtcctttgac 3310441 caaatatgca actgtaatca aaaggtagat cgccgcagta atgccggtaa tgacaattga 3310501 tgttgtcatg atgaccccga tcagaatggc gagtaatgcc acaatcgcaa accatgtcgt 3310561 gtacgggaac cattttacat aataggccgg tgtttccgtt tgctgttttc tcgattttaa 3310621 atgagcgaat ccgatgatca gccaaatgaa taaaacggta tatcccaatg atcccattaa 3310681 ataattaaat gtttggcttc ctgcgaacag agaaatcaat acgccaatat agagagaaga 3310741 agtgcacatc agaatcgcaa acatcggtac gtttttcgat gaaagcttcg agaagacctt 3310801 tggaagcctt ccgtcacttg cctgtgtata caaaatgcgt gatgatccgt ataaacctga 3310861 attcatagaa gaaatgatcg ccagcaggat gactgcattc atgatatgat ccgcgcccgg 3310921 aatgcctacc attttaaaga ccatcacgaa aggactttcc ggaacggaat tgacttggtt 3310981 ccatggaatc aggctgacga tgatgaaaaa cggcagcagg taaaacgcga caatccgtgt 3311041 cagtgtgctg cggacagctt tcgggacaac cttttccgga ttttttgtct ctgcaagcgt 3311101 tacaccgata atttctgtac cgccgtaaga gtagatgacg acaagcatcg ccgtgatcag 3311161 ccctgtgccg ccgtgcggga aaaatccgcc gtggtctgtc aggttggaaa atccggatgc 3311221 tgtatgatca ccgaatgata caaataagag cagcaatccc agaataataa agataataat 3311281 aacggtaatc ttgatcattg ccagccaata ttcagtttcg gcgaagattt taacagaaag 3311341 caagtttaca atcgtgacga taagagaaat tcctaatgcc aacacccaga tcgggcagcc 3311401 cggcagccaa tattgaatga aaatcgcagc tacaacagct tcagccgcaa tgttaagcac 3311461 ccacattttc cagtagatcc agtccaaaaa gtaagcagcg taatttccca atacctgctg 3311521 gacaagatca cggaaggttc tggcgttacg gtttcgaaca gccatttccg ccagcccctg 3311581 cataataaac agcaaaataa tcccgccgag caggtatgcg ataatgacag atggccctgc 3311641 cacatcgatc gctgagctgc tccccttaaa taaacctgcg ccgattgctc cgcccagcgc 3311701 catcatcata atatggcggg acgtcatcgt gcgttttaac gtttgattgt cgtttttcat 3311761 cctcttctac ctctccttct cgttttcaaa aacaaaaaag cccgccgtct cctacctaat 3311821 ctaatagata aagagacgac gagccttcgg ctgaccgcgg taccactctt gttgattctt 3311881 catgaagaat cctgcttttg acctgtaacg aaggttagcc gttaaaacat agggaatatt 3311941 caatctattc cgttccgtct taccactccc gggcgagttc aaagaagaat caggctgcgt 3312001 cgcaccaccc cgcagctctc tgttctgatc actttctttt actgctccca atctatgtgt 3312061 tttagttttc tgaaaaactc aaattttatg atctgaatat attaacataa tatacgtgct 3312121 tctcttttaa ctgtcaataa cttcagagaa aaaagaaact gttattttgt cccttttcga 3312181 atggctttcc aaaaggattc tgactcgttt cctaatgcgt aaactgaaac acctgctatt 3312241 ttatattgct ttgccagatg gcttttcgtt tgaacggttt tttcgttttc ataccacacg 3312301 acatgtttat gcttcttttt gtcaacataa gaaaacgtca tcgagcctga ttttttgttg 3312361 aatgccggct ttgctttttg ttttttgatg agggatttga gctcattcca ttcccttatt 3312421 gtgctggtac ttccgtcttt tacatcccag tcatagccgt acgcagggat tcccatgatg 3312481 actttattgg ctttgatctt tttgactgaa aactgcagag agcttttgat ccagtttgtg 3312541 cttgccactg accccggctc accccaaatg ccgtgttcat cgtaggtcat gacttgtacg 3312601 aagtcggcat atttgccgat tttcgcataa tcatacggcc agctccagtc atcattttta 3312661 tcatcggcgc ttttggccgg aacggatacc attgttttaa tatgtttctt attcaaagcc 3312721 tgtgagacat attgaatgaa gttcgagtat gcagcgcggt cttctggatt tactgcttca 3312781 aaatcgatat tgattccgta atatgagtgc tttttggcca gtgtaattaa ctgatctgtg 3312841 aatcgttttt tcgctgtttt attgctcatg acccgactcg ctaaatctcc gtcaaaatca 3312901 taaatggcat cattatagtt tgaaatgaca gcccatgtct tgattttttt ctttttcgca 3312961 tatgtcagct gcttagttgg ggcatcgcca atgatttgtc cgtttttttc aaacgcaaat 3313021 gtatcggttg cgatggcatt catgtatgta tgatatttcg taagagaatt gtatgaagcc 3313081 gtatccccag tcgtgtagcc tactgtcata ccggctgcct tcgcttctcc ttttgtatac 3313141 ataaacagaa caatcgcaat cgccagtgaa accgctatga tcagccattt tttcatcgca 3313201 tttcctcctg tatcaagtca tactcttctc atcggccaaa aaattggaag ttgaagtttt 3313261 ttcaagcaaa aagcccggca tatgcctgcc gggcttcctg agttcagcgg tcagagacga 3313321 gaatatatgc tgcctttact ggtccatgca cccccacaac taaatccatt tcaatgtcgg 3313381 ctgagttact cggtccggta atgtagttga tacatgaagg aacagtgaca ccgttcgcaa 3313441 tgttttggcg gatgatatca ctggcttgtg tcattctcgg tacaatgctt gatttcggca 3313501 cgatcgcaat ataagtcgtt ggcaaaaggc tgacagagcg gccgatgtct tttgaggaga 3313561 agaggacaac cgtccccgac tcagccaatg taatttcgct gaatgtaatc cctacattgg 3313621 cttgctccgc ttttttaata ttttcctcgc ctttgtcagc atcccactcc cagaccggcg 3313681 ttccttcact cggccagtcc ttggtgagca ggcttttcag tccgtattct tcaaagcggg 3313741 ggtccttcgg aatgatgaca gggcctccag aaaagcggct gacttgctcg cgcagggcat 3313801 cgtaaaggcc ggttgaatcc gtttcaatca gctctgtatg gattttgaca caatggtttt 3313861 tgagcactgt gactaagtca tccgctgaat aaccttcaag tgttttatat tgcggctgat 3313921 gcgcccattc agggactgcc acgcctcctg ttcttcgttc acggcccagg ctggatgcga 3313981 ttcggtttaa aaagctctct tgattctgaa tggttccctt cgtcatcact gctcctcctt 3314041 cgtgcgttca cttgtttctc tgtccgcaaa ccagtctctg aatctcgatt tatgcggtgc 3314101 cgggaagtcg cgaatctggg tccaattttt aagcgggccg ggccctttcg aaattttttc 3314161 gtcctctgta aaaggcgtca tggcggccgg cgcccatttt gagcccattt tgtaaagcga 3314221 taaggaggat gcgccaagtc cgaatgcttt cattgcaagc ttttcactga tcggcgccct 3314281 gccttctttt tcgacgatat tctgacgatg cttgagtagc agctcatgaa gcgggatttt 3314341 gaccgggcag gcttctgaac aagcagcgca cagtgaagat gcgtacggca gctccttata 3314401 atcgtcataa ccgccgagca acggtgataa aacagctccg atcggccccg agtagattga 3314461 gccgtatgaa tgtccgccga catggcggta cacaggacag acattgatac aggcggcaca 3314521 gcggatacat tgcagcacag actggaattc cgttccaagg atattggatc gtccattatc 3314581 aacgatgaca agatggaatt cttccggacc gtccacttca ccttccagct tcggacccgt 3314641 caaagctgta atatagcttg tcagccgctg tccgacagca cttctagtca gcatgctgac 3314701 tagcacttca aattcagaaa atgacgggac aatccgctcc attcccatga cggtaatttg 3314761 tgttttcggc aaggtgctca caagccgtcc atttccttca ttggtcacaa ggctgacgga 3314821 acccgtgtca gcgatggcga agttacagcc ggtaatgccg atatccgctt ccagaaactt 3314881 tttccggaga atggcgcgcg catgcatcac cagctcttcc ggtttttctg tatgttgata 3314941 gtccagtctt tctttaaaca catcgcgtat ctgctcttta tttttatgaa gagcgggcgc 3315001 tacgatatgt gacggcggat cgtgatcatc aatctgcaaa atatactcgc cgagatcggt 3315061 ttctacgact tcacagcctt ccttctccag cacctcattc agattgattt cctctgtgac 3315121 cattgattta gatttcacaa ttttcttccc gttcttcttt tgaatgacat cccgaatata 3315181 ggaagacgcc tcttccgctg ttttcgcgaa atagacatgt ccgcctcttt tcgccacatt 3315241 ttcggcaagc tgtccgagat agaaatcaag gttttcaagg acatgctgcc tgatttcctc 3315301 tgataatgag cgccactcct cccagtttcc cagttcttct gctgcctcta ggcgccgcgt 3315361 ccgcagacgc tcctgtgcac ctgaaacagc gcctctcata aattcattat caatcccctg 3315421 tgatacccgc tctttaaaag cgtcagtacc gattttcatc gccatgatcc tttccccctc 3315481 tgaatccagt tttatctgct gttgagcact tcggcgatgt gcatcacttt gacattctta 3315541 tcttttcggc caagccgtcc cccgatattc atcaaacagc cgcagtcagc accgatcagc 3315601 acctctgctc ccgtttcctc cacacattcg actttttcat cgaccatctg ctcagaaatc 3315661 tgcgccatct tgactgagaa cgttcctccg aatccgcagc agttatgttt gcccggaagc 3315721 tctgtaaact gcaggccctt cacatggctc aacagcttca tcggctcctt ccgaacaccc 3315781 agcagcctag tcatatggca cgacgtatgt aaggtcgctt ttgtatgaag ggtcgcgccg 3315841 acatcctcta ccccaaggac gttcacaata aaatctgtca gttcatacgt tttatccgcc 3315901 agctttttcg ctttatcggc ccatttcgga tcatcctgaa acaggtgcgg atactcccgg 3315961 aacatcgttg tgcaggaacc cgaaggactg acaacatatt cggaatcctg aaacgtttcg 3316021 atcatccgtt tcattgcttt tttggcgtca tgtacatagc cgctgttgta agccggctgt 3316081 ccgcagcaaa tctgcccttc tggaaaatca acctcgcacc caagccgctc cagcagctca 3316141 accgttgctt ttccgacatt tgtttgaaac atatcaacaa gacaagtgac aaaaagtgag 3316201 actttcatga tgaacccctc tctcatcccc aatatatgat caggtcatct gatgacctga 3316261 gttaaaataa ctatatgaat atcgtacact attctgacaa tggaaggaaa gagttttcta 3316321 gggatatttt catttgtggc atatcaaaaa cactcccgat ctcccaggag tgcagtatat 3316381 ggttagatcc agcccttttc ctcagcgatg ctggcggctt ctgtccgatt tttcgcatta 3316441 agcttttgga tgatttctga gatatagttt cgaactgtgc cttgagataa atagagctcc 3316501 agcgtaatgt cttttgttgt cttgcctaaa gccgcaagcc tcagaatttc ttgctctcta 3316561 acggttagcg gattttcgtc tcgcatcata ttaaacgtca gctcagggct gaagacacgt 3316621 tttcccttta cacattttcg aatggcatcg gccagatcgt caatttcacc gtctttcagc 3316681 agatagccat gtgcaccggc ctttacggcg cgttcaaaat atccggggcg ggcaaaggtg 3316741 gttaaaataa tgaccttgct gacgcagcct tttttcatta attcctctgc cacattcagc 3316801 ccgcttcgaa ccggcatttc aatgtccata atgcatacat ccggctccag cttcaaaata 3316861 gcatgtagcg cctcttcccc gtttaatgct tgtccgatga ctgtcatatc ctcttctaaa 3316921 tcaagcaaag atcccaaagc gcctaaaagc attcgctggt cctcagcaat aaacagacga 3316981 atcattcttt tcgtcctcca atcattctgc ttttttaata agcggaatcg tcagtgccac 3317041 aaccgttccg ttatggtctg aaaccgttaa tcccccttca atgagcatga gccgttcttc 3317101 cattccccac aggccattcc caaacatttt ctccttcggc gctccctttc cgtcatcccg 3317161 tattacgatc ctcattttgt cagcaaattg agaaatggtg atggcacagt gggttgcttt 3317221 gctgtgcttg ataatgttag tcacggcttc ccgcatacac atactgataa tattttgagt 3317281 gacgggagat atcactgaaa agtcgtcggc tccttcgtat tgaaaggtaa tgttccccgc 3317341 tcttaatatg tgctgaatgt ttacgagctc ctctgttatc gtgaccgttc tcatatcaga 3317401 aaccagctct cgaacttgct tgagtgcgga gcgtgaactg gtttccattt cttttgcctc 3317461 aagcttggtc cgttctggat cagatgcagc cagccgctga atgagctggc tttttaatgt 3317521 aagcagcgac agggtgtggc caagagtatc gtgaagatca cgggcgattc gaacacgttc 3317581 ctccctttta gagagttctt ttatctgttc gttggcttgt gcaagcttag cttcaagctc 3317641 aatcctccga aacatagaac gaattccgaa tggagaaatg agcataatga cgagaaacgg 3317701 gagaacagaa aaaagctccc gaagcgagac cgaattcgcg ataaattggt ataggcatgg 3317761 aaaaagcagt ataaagatta aagcgcagaa cgcacggtta aaattcgttt tctctttgta 3317821 ataaccaaca aagtttgccg gaaaaaaacc taagtatata taggtgatat tgtaaaacac 3317881 actatacatc aaaataaccg ccatttgcac gataagccaa tatgtaaacg aagctttgcc 3317941 cacgctgcag aataactggc gatatgccgc tacaaaaagg agcagcatac catatccgat 3318001 cccctgtttg acccctgatt cttttaataa agagaggaac ggcataatcg tatacaccag 3318061 aaagatataa gggaaaaacc cgaattcctt cgggaaaata gatattgcct ttttcatgta 3318121 ttacaccgct tcttgttttc ttcttatata tttagatagt agcatgaaga gcatcatata 3318181 agcgattaat atcagaatat ttttccaagt cggactccca ccccggacaa gttcccacgc 3318241 tccgctcccg aaatgataag acggaagcca ctggccaatg ctctgcatca tgtcaggcat 3318301 gacctcaaac ggcatccaca tccctccgcc taaagccagc agcatataaa gcacattact 3318361 gattccggcc gctgtttcta cttttctcat gaggccgatt agtgtgccta atgctaaaaa 3318421 aggcaatgcg ccaaacaaaa tccacagtcc gctcatcatc cattcaaacg gtgacaaggc 3318481 aatatcattg atgattgcgc cgaacagaaa tatgacggta attgataaaa cgtgaatgac 3318541 actttggccg atcatctgag ctgataaata gatatgatcc ggaagaggcg taaggcggat 3318601 aaaggcggcc cagccttgtg accgttcttg taccattcgg atgccaagcg tcatgataga 3318661 ggaacccatc acgctgaaga ctgtcatcga catcaggtaa tgggcttccc atgcacgttg 3318721 atcagggacg ttggtattca ctacatttgt aaagaaataa taaaaggcaa tcggcatgat 3318781 cagagaccaa agcacaaagt acttgttcct aagcaccctt ttcatttcag cgatgctttg 3318841 cttttgcagc acgttcactc acatcgcctc cctgttgccg tcagccagct ggcgaaatgc 3318901 ctcatcgagc gttgcttgct caattcgaat atcccgtgca tgtatgtttt cttgaaagat 3318961 cagcgccaac actttgtctg tatttgatgt ctggatgatg gttctctcat gctcgtggat 3319021 cactctctcg acttccgggt gacaagacag cctttccaat gattcacttg aatgaagcgt 3319081 aaaggaaaca gactgttttt gaattcttga gcggatttgc attggtgagc cgtctgcaac 3319141 aagctgtcct tcagtaaaaa ataggattcg ctgtgcggca tcatctgctt cctgtaaata 3319201 atgagttgaa aaaataatcg tttttccttg gtccgacagt ccgtgaatgg tctgccagaa 3319261 tcggtgtctt gatgaagtgt ccatgccgac tgtcggttca tcaagtataa gcagctccgg 3319321 gttcccggca agagccaaag caaagctcaa acggcgtttt tgtccgccgg ataatttttc 3319381 tgctcttgtt ttcaaatctt ctttggtgag tgctgttaac gaaacgagtt ctttcatgga 3319441 caatggattc ggataatagc tccggaagag ttcaaggatt tcatccacct taaggcccgg 3319501 catgacactt acttcctgaa gcattacacc tattttttca cgaacctgtt gatcatcggg 3319561 aacccggtta aatagtttga tttctccctc actcggtttc agcaatccta atatcatcga 3319621 gacgacggtc gtcttccctg ccccatttgg cccgagaatg gctgcaattt ctcctttttc 3319681 aatactgaag ctgatgttgt ttacagcggt ttttcgctgg aaatgttttg tcacgttgct 3319741 tactgttact gcttctttca tcacatgagc acctcctgat cgtttacatt gattgtaaaa 3319801 tgacggagaa gacgatgtta gtatggggtg tcatgatgat ggagtgacaa atgtcatttt 3319861 tttctcaccc cggtgtctag gcaatcctcc tcctgcatct tccaattcat ccatcttttc 3319921 tatctcccat gtcctctttc ttttaaactg ctgtgacatt catagaaaga tacactcttc 3319981 aaaccatccg agtgttatga tagaaatatt gaactttata ttactttccg gctgaaagga 3320041 gccaatcatg aacgaagcga ttttgtctag aaatcatgtg aaggtgaaag gcagcggcaa 3320101 agcatctatc atgttcgcac ctggttttgg atgcgatcaa agcgtgtgga atgccgtggc 3320161 acctgccttt gaagaagatc atcgggtgat tttatttgat tacgtcggtt cgggacattc 3320221 agatttgcgc gcatatgacc tgaatcgtta ccagacactt gacggctatg cccaggatgt 3320281 tcttgatgtt tgtgaagctt tagatctgaa ggaaaccgtg tttgtgggtc actccgtcgg 3320341 ggccttgatt gggatgcttg catccatccg ccgcccggag cttttttccc atctggtgat 3320401 ggtggggcct tctccttgct atttgaatga tccgcctgag tattacggag gatttgaaga 3320461 ggagcagctc cttggcttgc tggagatgat ggagaaaaat tatatcggct gggcgactgt 3320521 atttgcggca accgttctga atcagccaga tcggcctgaa attaaggaag agcttgaaag 3320581 ccgtttttgt tctactgatc ctgtcattgc ccgccaattc gcgaaagcgg cgtttttttc 3320641 tgatcaccga gaggatcttt cgaaggtaac ggttccctct cttattctcc aatgtgcaga 3320701 tgatatcatc gcacctgcaa cagtaggtaa gtatatgcat cagcatctgc cttatagcag 3320761 tctgaaacaa atggaggctc gcggacattg ccctcatatg agccatccag atgagacgat 3320821 acagctgatc ggcgattatt taaaagcaca cgtgtgatat aggaacgaaa gggatagagg 3320881 tgaccctctt agatggacaa acaattgaat gatgcaccat gcggtttcct cgctttgtca 3320941 gaagaggggt cgatcatagc tgccaaccgc acccttatca agattctgga ttatgaaccg 3321001 gagcaggtta tcggccagca catgaatatg atgttgacca ttcccgcgca gcttttctgc 3321061 cagctttatt tttttccgct tttgaaattg gagcatcaca tcgaagaaat atacatttcc 3321121 ctgaaagcaa gagatggaga agaaattccc gtccttatca atgctattgc gagacacgat 3321181 agcggggctt ctgtctttga ttgtgttctg attccaatgc gaaagcgaaa tgaatatgaa 3321241 aatgagctgc tgatagccag aaatgaggct caggaagctt tgcttgccaa acagaaagcc 3321301 aatgcggagt tagaaattgc cttggaaacg ctgaaagcaa aacaagaaga acttcttgag 3321361 atcaataaac aaaatcaaca atttaaatta aacaccaaaa gagagcttga actcgccaga 3321421 aagatccaga aaaactcgtt gactgaaccg attgtaaacg atcaggttca gattgactct 3321481 tattacaacg catcgagtga attgtcaggt gatctttacg gatattatca aatcgatgaa 3321541 caccgttacg gcattattat ccttgatgtg atggggcacg gaatttcatc tgcattgatt 3321601 acgatgtctc ttcatccttt gttccagcgc cagatcacgc aaggtctcag ccccgttaaa 3321661 gttatgaagg aattggaccg gcaccttcac agcttgtttc aaaatgatga ggaagcaaga 3321721 cattattgca ctgctattta tctcgagatt gatatagcac ggcaaagaat tgattatgtc 3321781 aacgcagggc atccgccggc actttggcag gacgatagcg gaactcaaca tctgcttcac 3321841 gcgacctcgc ctccgatcgg gatgtttgaa gacttagagt ttcagtcaag cagcctttca 3321901 tacacggagg acggaagatt gcttctgtat acggatggcg tgatggatcc tacggcttca 3321961 tgttatttat ttgatttact aaaggatcat cctgattcgc caatcgctga cctgaaggag 3322021 aaaatcctta catcactgca gcatcaaaag gaagctcatc ataagagtga tgacgaatgt 3322081 tttatattag ttgatgtaaa ataaaatgat ccatgagaca taacaatgat ttgttacatc 3322141 tcatggattt ttttgtttca gcgtttcttt ggaatatgtc ctgactccgc atattgaaac 3322201 acctgcaagg aaggcagcgg gtgtccatta aaatcaaata aagcttgatt atctacagca 3322261 cttcccccat accacttccc ggcgtcttca gggtcgtatt cagcagcata gctggacgcc 3322321 caccctgacc cgtatgtttc ccataacact ttgtttttct ctatctgtgt cttcggcccg 3322381 actggaatcc acgccggctc ccagtagaaa acaccaagtc ctgctttgcc cgtattcgcc 3322441 actgcctcca ttacatctct tactgcagtt gcctggcctt gaacagaaat tggatatggc 3322501 aacgtctgcc cgctttttgg tgctgtattt ccatgcccat cgccatcctc agcggtatag 3322561 gtgtacgatg tctccgccac catgactttt ttgccgtacg tattggcaac agccttcagc 3322621 acggaggtca aattttgtaa tgtgccatgc cagaaaggat aataggagct agcaaacaca 3322681 tcataatcca ctttgttttt gctgagtgtt tctgcaataa atgaatacct tccagccgtt 3322741 tcaggattgg taaaatgcag ggcgaccaaa atatttgaat ttgtctccct gaccgctcgg 3322801 cttccttcat taaataattg gcacatcttc gtccaatcag tctcaccggc aaatcctcct 3322861 gttgtttcat ttccgacctg aaccatgccg atgtcaacgc cttccttgat catcttttgc 3322921 aggctttgtt tcgtatactc atagagcttt gctttttttg cttcaaagct gagattcgcc 3322981 caggctttgg gcaccttttg tttcgctgga tcggcccaga aatcagagta gtgaaagtcg 3323041 gccagcacct tcattccgtt cgctgtcgct ctttttccga tttcgatggc tttttgaaca 3323101 tcattgtttc ccccgccata cccgttgcca tttgaatcat acgggtgatt ccagatgcgg 3323161 acgcgaacat agttgacccc agcctgtttt aaagttgtaa agatatcctg gcgttttccg 3323221 tttgtattgt aaaaggtgac accgctgttt tccaaagcaa taacgctgga tacatctgcc 3323281 cctttgataa aatccttgtt catcccctct acttttttaa caaaaagatc ctctgcccga 3323341 agctctgaca cgtgcttctc cttctcaatg gcagcggcat atcctgttga actacatgca 3323401 ctccacacga tggcagccgc aaagaacatt ttcactttgc ttttcatgat ttcatccccc 3323461 caagacttag caagcgtttt cattctatag aaaaaagaat ccgcccatat cgagcggagc 3323521 atcagcctaa tgtgtgttta cgacaattct cacttcatac ttttccatcg tcaggtcgcc 3323581 tgacaatatg tctcctgtca ttatgtcctt cacactctga tcaaacgtga ccagctgttt 3323641 ttcttccgtg aaattcatga caaaaatata atcattgtcc tgatcctgcc tcgcttgtac 3323701 ggagacgcct tttccgtgcc gaaccggaaa aactggagag agagacaggt ctgtgatcag 3323761 accctcatag aaatcacgct gaaattgatc ctccaaacgc gcgccgataa aatacgcctt 3323821 gccctgctga tactcatggc ttgtgaccgc tggcgtgcgc gcataaaaat cttcttgata 3323881 caccgcttcc actgaagctg tctttacatc aatcacggtt gcataatcct tcatttcata 3323941 tatttggctg cggtagctga cagcgtttcg atccttcgga tacagggtgt ccgtttcaag 3324001 aggctcaact ccaaatatag cttgaagatc cggatgccat ccgcctgtgt atgttaagtc 3324061 atgctcattc acaaccccgc tgatatacgt catgactaag gtgccgccgt cagccgtaaa 3324121 cgcttttaaa cgggaaacgg tgtcctcgct gattaaatac agcatcggga cgatcagcag 3324181 tttatatggt gaaaagtctt gttctttcgt gatgacgtcg acagggatat cgtgttccca 3324241 gaatgtgcgg taatgctgct gaagcgtttg cggataacgt tttgtcgcct tcgcaaaccc 3324301 ctgagcatcc tcgagcgccc aatgattttc ccagtcatat aaaatcgcgg tttgagccgg 3324361 cctcttcgtt ccgacaactt cggacagccg ttccaatgtc tcgcctacct tggccacttc 3324421 ttgaaagacg cggttcttcg ggctattgtc atgatccaca accgctccgt gtaatttttc 3324481 tgatgacccc cgtgatttgc ggtattggaa atagagaacg ctgtccgagc cgtgggcaat 3324541 catttgcatg gatgacagca gattcatgcc cgggcgcttt gccttgttga cgttatgcca 3324601 attgaccgcg cttggcgtac actccattaa taagaagggc tgctgcttca agcttcggta 3324661 cagatcattg ataaagccga ccttcatcgc caaatcagct gtgctttccc agtcattgtg 3324721 ccagacagga taagcgtccc agctgatggc atcgacatgc tttgcaaatt tgctgtagtc 3324781 gaggccctga tacgggatca aatccggtgt gtcagccata aaattcgttg tgatagggat 3324841 atcaggcgtc aattctttca gcggaatgat ttcattttca taaaacgaaa tcgtttgatc 3324901 ggtgacgaac cggcgccaat ctaaattcag gccatgcaag ccattttcac cgatcggcga 3324961 agggctttca atttgtgacc agtcattgaa cgtatggctc caaaaagggg tccaccacgc 3325021 atggttcaat gtcttgaggc tgttgtcata tttcgatttc agccactccc ggaaagcatg 3325081 ctggcataaa tcacagtggc aatctccccc gtattcgttt gaaatgtgcc acattaacag 3325141 cgccgggtga tgtccgtatc gttctgctaa taagcggttg atgtgccgtg ttttttctcg 3325201 gtagacttta gatgtgaggc agtggttgtg ccttccgccg tgcagctgtt tgacgcggga 3325261 ggcattgacg cgcaaaactt ccggataggt ttgcgacagc caggccggac gggctccgct 3325321 cggcgttgct aatatgaccc ggccgcctat actgtgaatc cgctcaaaaa tatcatccag 3325381 ccattcaaat tgatatacgc cctcctccgg ctcaagtgcg ctccatgcaa aaatgccgac 3325441 agaaaacgta ttcgtatgag aaagcttcat cagtttgata tcgtcagcta aaatatcggg 3325501 ccgatccagc cactgatcgg ggttgtagtc tcccccatgg agcataaatt ttgcttttgt 3325561 tacgtgcgtt ttttcaagct ttgacatcac attctcctcc ttgttctctt agcccttcgt 3325621 tccgcctgcg gttaatccgg acacaaaatt cttttgcagc ataataaaga tgacggcaac 3325681 cggtatgctg ataagcaggg ctccggccgc aaatgtcgta tagctggccc ccatgacatc 3325741 attcactaaa ttgaatagac cgacgggcaa tgtatatgat tcaggcgttc tcaatatggt 3325801 tgaggacagc acaaaatctc cgagcggacc ggtaaagccg ttcatggcca cgactgccgc 3325861 catcggtttt gataatggca gaatgatctg gaagaagatt ctggtgctgc tggctccgtc 3325921 aatcttggcg ctttcgtcta aatccatcgg aatggaatcc atgtaccctt tcatcaaata 3325981 cgtattcatc gggatcaggc cgccgatata aagcaagatt agcagccagt ggctattgat 3326041 cattcccaag atttgcgcca gcacaaacaa ggcaattaaa gctgaaaact gaggaatcat 3326101 ctgcagcaat aaaaagagcg ttaaagcgta tttcctccct ttaaaccgaa agcgcgaaaa 3326161 cgcataggcc gtaaacgtca cacagagcaa agaccctgcc attgtaaaca ggctgatctt 3326221 catagagttg acataccact gcacatattg aaggctttcc ttgcccgcaa ataattcctt 3326281 gtaatgatcg aatgtcggat gcttcggaat gatggatgta ctgattaagc tgttgccggg 3326341 attaaagctt gcgcctgccg tccaaaggag aggataaaca atgatgaccg ccataaaggc 3326401 tagcaacaag taagagaaaa ggagacggat atatcttctg actttcatat ctgccagcat 3326461 accttatgcc tcctctttaa aagactttgt ctgtctgaac tgccacaatg cgatggagat 3326521 aacaaataca gataataaaa tggttaaagc cgcagcaagt gaatattggc tggactgcat 3326581 tgtcaattta taaatccatg aaacgaggat atctgtcccg ccggctgttg atccggttac 3326641 agccggacct ccgccattga atagatagat aatattaaag ttattaaagt taaacgtaaa 3326701 ctgagtaatg ataatcggag ccattgcaat gaacaccatc ggaagcgtga tgtatctcag 3326761 ctttgaaaag acagaagcgc catcaatcgt agctgcttca tacagatcgt ccgggatgga 3326821 ttgcaatacg cctgttgaga cgagaaagat gtacggaaat ccgagccagc cctgcatgag 3326881 aatcaatgca agcctcgacc aattggcatc tgtcatccac ggaagcggat ctatcccgaa 3326941 gaaagccaag atgtcgtgat tcatcgcacc gaagctatca ttaaacagtc ccgcaaaaat 3327001 taaaatcgtc acaaaaccgg gaacggccca tggcaaaatc agaatcgtcc gaaaaaaacg 3327061 tttaaaccga aggtctttct ggttaacaat gatcgcgaga aaaatcccca aggtgacttg 3327121 cagtgtggat gcagcaagtg tccaaaccac cgtccaagcc agtacatcaa aaaaagtcga 3327181 cctccaaata tcaactgtga aaatatttgc gaacgtttga aaaccgaccc aatcaattaa 3327241 ttttgcagga ggagaatgat acaaatcata gtttgtaaac gctaatgcaa agctgaataa 3327301 gataggaaag atcacggcga aaattaaaat aaacaaagat gggccgctga cgacataagg 3327361 atagccctca gaaatgatat gctggtattg ttcctttaag gaacttaatg gcttattttc 3327421 atcacgctgt tttccgcttt ggaacgcatc gcgaagattt acataataca ccgcaaggcc 3327481 aaagcaggtc acgatgacag caataatccc ttccgccagc agaaaaacgg aattatcccg 3327541 cggcacttct gttcccagtg taaagattcc ccaaaacccc atattgagca gatctccaaa 3327601 gaccgcaaaa aacgatgcgc ctaagaaaag aaagacaata ccttttatcc attgcttgtt 3327661 ataaaattgc ccgagtcccg gaatgataga aagcaacaaa gcgacttgac gatgctgcac 3327721 cgttttcacc tctcttacaa tacaaatcta gctttctctt tattttccgc tgtgctttgc 3327781 cttaatttgt cctttggccg tttcagctgc ttgatccaat gcttgtttcg gatctgcctt 3327841 ccctgttgca accgtctgta atgctgaatc agccggcgtc catatttcat tcatttccgg 3327901 aatatttggt gttggctctg agaaacggga ttgttcagta acagcccgtg ccgcctcgct 3327961 tttcataata gccgggtcat tggctaggga tttcacagca ggaacttctt tcgtttcttc 3328021 atatcgtgtt ttagaatttt tttcatttgc caggaaaacg gctaattctt gcgccagctc 3328081 ttcattcttt gaaaatgcac tgacgttgta gcttttgacg ccgataaagg agctcatgtt 3328141 tttcccattt tccagcttcg gcagtttcgt aatgccataa ttgattcctg cattcgaaaa 3328201 ggcttctaca ttccatggac cagaaataat tgcggcggct tttccttctg tgaacagcga 3328261 ttccaacacg ttaatccctt gttctccaat aatgccagcc gggaacaggc catctttgta 3328321 aaacttctga atcagcgccg cacctttgac agctccttca ttattgattc caatgtctga 3328381 cgggttatag ctcccatctt tggcctttcc aaaaatgtat ccgccatatc cgctcatcac 3328441 actttctgca taataaattt gatcgaatag ggctaaaaag ccaaatttgc tgccgtcagc 3328501 agtctttttg gaatagtcgt accactcttc cagcgttttg ggcaattcct tttctgtgat 3328561 gagatctttg ttgtaaaaaa gcacagtcgt ttcgaccgct tttggcagtc cataaagctt 3328621 ttgatctacc atttgagact gaatggaagc gtcagtataa agtgattgaa cgtctttttt 3328681 gacatgtaat tccttgagta atccttccgt gacagcggtt ccgatttggt cccctggcat 3328741 tgttaacacg tcagggcctg tgccggccgg tccatccatt cgcaaatctt caatctgctt 3328801 ggcatacggt ttttcaacga ctttgacctt cacatcatgc tctttttcaa atgcagccac 3328861 agcgtcttta atgccgttgc tcttttcttt atcctcccat acaacaagct ctgacccttt 3328921 tgaactcgat ttggcgctgc tgctttcctt tgggccgcaa gccgccaagg ataaactgac 3328981 agctgcgcag agcatgaata cggaacactt ttttgccatt ttcattgatt gtcacccttt 3329041 cggtaggaat gaaagcgctt taaagataat atagcatgcc tgagaaaatg tgtaaacaaa 3329101 ctatttactt catagagtaa atttttttac ctaaataaaa aatgacttag tgtcctaagt 3329161 catccttaat tcatactctt cctgacgatt aattctgcgc ccacatataa tgtttttacc 3329221 gttcttctct tgtcctgcac ttgttcaagc agtaattgaa cagcgttttt acataattca 3329281 tgtatatcaa tatgaaacgt cgtcagagga ggcgagacat acttcgcgaa gctgatgttg 3329341 ttgatactca caatgcttac cctgtttggt atggcaattc ctttttcgtt cagggcttgc 3329401 agacagccca ctgcaatcgg gtccgctgca atcataaaag cagtcggaag ctgatcgcct 3329461 aatgtgtcga tcgctgctga catcaggcgg tagccgtttt ctacagagaa tccgcgatga 3329521 cagaaaatat agcgctcgtc cagcatggct ttttccctca tataggatct gaaggtttgt 3329581 tcacggatgt ccatttcatc ctgattggta ttcggatttt tgtatgtgcc gccgataaaa 3329641 ccgatgctct tatgcccctt ctcagtcagg atgtttaccg tcttccttgt catttgtgcc 3329701 aaatcgggcc ttaccgagtc aaaatgatcg ggatcaggag ttgaatcgat gaacacgccg 3329761 ttttcagtga gatttctgag gaaagccagc tcttcatctg aaaatgtgcc gacggcaata 3329821 aacccttccg tatgttcagg aatgctctcg attccatccg ctattttata agtggtcata 3329881 tcgacattga atgctttcgc cagtttctct acttctaatc tcatcgtttt aaaatagaca 3329941 tcttctaatt cttctttatc tgtcagccaa tataaaaacg caatatgttt caccagcggc 3330001 cttactgttt ttttgcggta attgagcttt tccgccgctt catagatttt ctcccgtgtc 3330061 tcatcaggaa cagaaaggct ttcatcgtta tttaaaacgc gggaaacggt tgagattgaa 3330121 aatcccgctt cctgcgcgat atctttaatt gtcgccattg tatctgcctc cattattcag 3330181 ctcgcattgt tttagtaaaa tattttactt tctttttcac aaatgtcaag tgcacaaagc 3330241 cctctggctg ccatgtaaaa agactgaacc atttgcggct cagtctcagt tgttcgtatc 3330301 attcggaacc ggcggaattg cccgggaaat gagttggtta ttgcacattt tcctcgaaat 3330361 atcccgaaag cacatcttcc acattcgtca aatgcgccag catggcggct tccgcctgtg 3330421 caccgttccc ggcagccaca gcattgtaaa tccgttcgtg ctcctcatac agccgctgaa 3330481 cggaggtctt cttggaaaac agccagattt tcctcgtttc cctcattgtt tccagcagca 3330541 atgatgacac gtgattcatc aagtgtttaa gaagttcatt ttgagaagcg tccgcaagcg 3330601 caagatgaaa tgcaaagtct gctttctctc ccagctcccc gtccgcttca atgctgccca 3330661 tttcctttag tgcatcctga attctttcga gatctgcttc tgtccttttt tcagccgcta 3330721 gtgaagccac gccgatttca agcagttttc tgacctcgag cagctgcttg acgtcctctt 3330781 ttttcatcag aagggcggct gagagcggct gagaaatttg attgagctca aattccttca 3330841 gatacgtgcc ttctccctgt ttcatttcga caagccccat cgcttttagc gcagaaagtg 3330901 cttcgcgaac cgctgaacgg ctgacttgaa agctctcagc aagcgcctga acagagtcca 3330961 gtttatcccc cggcttcaat tcgccatttt tgatcatatc taatagggca tccgctactt 3331021 cttcatatat ttttttgttt taatctgttt atatttcaat gcaattcacc ccgtaacttg 3331081 taggtctggc tgtttacgat ctattatact ctgttttgtg ggccgccaaa agattttgac 3331141 tattttgtca aaaagtcttg tactttgatt tttttcaaaa tataatgcta ggtaactggt 3331201 cttattaccc agtcatcaga tgatcatatc atctatagaa accgcttaca tatggcgcca 3331261 gtttatgttt caaggagggg tttgggatgc aatggacaca ggcatatacg cctatagggg 3331321 gaaatttgct attatcagcg cttgccgcac ttgtaccgat tattttcttt ttttgggcac 3331381 tcgcgattaa acggatgaag gggtatacag caggcttggc cacattgggg atcgccctta 3331441 tcattgctgt attggtttat cgtatgccgg cggaaaaagc gctgatgtcc gcgacacaag 3331501 gagccgtata cggattgttg ccgatcggct ggatcattgt gacgtctgtt tttttgtata 3331561 aaatcactgt gaaaacggga cagtttgata tcattcgcag ctctgttctc tcgattactg 3331621 atgaccgacg gcttcaagct ctcttgatcg ctttttcatt cggggctttt ttagaagggg 3331681 cagcaggctt cggagcgccg gtcgccattt ctgccgcgct gctggtcggt ctcggcttta 3331741 atcctcttta tgctgcgggg atctgtttga tcgccaatac ggcgccggtt gcctttgggg 3331801 caattgggat tccaattaca gccgtagaag ggccgacagg gattccggcg atggagattt 3331861 cgcaaatggt tgggcggcag ctgccgtttt tatccgtatt tattcctctt tatttaatca 3331921 tcatcatgag cgggttcagg aaagccttgg agatctggcc ggcgattctc gtatccggtg 3331981 tttcctttgc tgttgttcaa tatctcagtt ccaatttttt agggcctgag ctgcccgatg 3332041 ttttgtcagc tcttgtttca atggctgcgc ttgctgtgtt tttgaaatgg tggaagccga 3332101 aaacaacatt ccggtttgcc ggtgaacaag agtcggccgc ctcaattgaa acggcgcgca 3332161 caaatccggc ggcgcctgca tacagaggcg gacagatttt taaggcttgg tcgccatttc 3332221 tgctgctgac ggcgatgatt tccgtatggg gcattccatc tgtcaaatcc gcgctgaccg 3332281 ggcattatga aggctctgcg gtgttcttga agtggctgaa tgctgttgga gaaaaactga 3332341 ctttttcccc cggtgtgcct tttttgaaca atcagattgt caatgctgac ggtacgccga 3332401 ttgaagcggt ttacaagttg gaggtgcttg gttcggccgg caccgcgata ttgattgccg 3332461 cagtgctgtc aaaattcatc acggcgattt cgtggaaaga ctggggaacc gtttttaaag 3332521 aaacagtcca ggaattgaag cttccgattt tgaccattgc ttctgtcgtt ggttttgcct 3332581 atgtcaccaa ctcctcggga atgagcacga cactcgggat gacactcgcg ctgacaggtt 3332641 cgatgtttac cttcttttcg cccgttctcg gctggctcgg cgtcttcatt accggctcgg 3332701 atacttctgc caacctgctg ttcggcaacc tgcagaaagt caccgcatta tcagtcggca 3332761 tggaccccgt tctgtctgtg gccgccaact cttcaggcgg tgtcacagga aaaatgattt 3332821 caccgcagtc gatagcggtg gcgtgcgccg cggtaggact cgccggaaag gagtcagatc 3332881 ttttccgctt taccattaaa cacagtctgt ttttgctgct gctcgtctgt atcatcacct 3332941 ttttgcagca tcacgtattc agctggatga ttccttaaaa aaatcctccc gtctagggag 3333001 gattttattt atatcgcttt ctcgctgccg atgacggaat attcatttga tcgcgatatt 3333061 ttgccacggt gcgtctcgag atttggatgc cgtgttgttc atacagcaaa tcgacaagct 3333121 tttggtctga aagcggtttt gttttgtcct cttgattgat caggttttcc agatgcgttt 3333181 tgactgcata attcgacgca tctccatcac ctgaagcctc ggcttttgct gagaaaaaga 3333241 gtttcatctc aaacagcccg taaggcgttt gtattgtttt ccctttaatg gcccggctca 3333301 cagttgattc atgaaggctt agacagtctg ccacctctct gagagtcagc ggcttcattg 3333361 cgcttcgccc tttcagaaag aaatcctttt ggcgtgtgat cagttcattg ataattctcg 3333421 tgattgtctg ttttcgctgc cgcagcgcgc ggctcagcca gcgccactcc tgatatttcg 3333481 cagataaata ggagacagta tcctgacagg agccggatga taaaagcgtt ctgtactgcg 3333541 gatgcagatc gatctcggga aacgagcggg tattcagttc cgctgcgatg tgcccatttt 3333601 ttacggtgat aaaaatgtca ggctcaatat acacatcttg ctctggccgg gcaaacagaa 3333661 ggccaggtct aggatgaaga gccgcgatat catctgagat atcttgaatg gtatgaagcg 3333721 gaattcccgt ctctactgaa agcgttttcc attttttttg cgcaaaagca tcaaaatgag 3333781 ctgaaaccag catttccgct tgttcatttc tgttcggcag ccgctgtaat tgaagaagga 3333841 tgcattcctg caaagatctc gcgccgattc cagccggttc taacgactgg agttttgcca 3333901 aaacagcctc cgcttccttg gccgatacag ataatcgccg tgctgcctcc tctatatctt 3333961 cttccaagta cccgtttgaa tcaagcgaat gaatcagata attaaaaatc tttttttcag 3334021 tgtttgtcag attcatatcg agtgactgct gttttaacgc atcctgcaat gttttttgcg 3334081 gattacttaa ttgaaggccc gcttcctgtg cattcatcct gtttttgttt gttttatggt 3334141 aagatagtgg cggtgtgtct gtttcctttc gttcaataag agggttttcc agtgagagct 3334201 catcaatgta ctcggcgagt tctgccgaat gatagccaag cagcgtgatg gcctgcctga 3334261 gctcctgtgt cagttgaggc tttaatactt gtacttgctg aagtttcata tccatcttgc 3334321 tcactcccct ttcttcattg tacatgattg agatcacacc gtatacattt atgaaaaagg 3334381 agctgccaaa gaaatgtctg aacttttttc cgtcccttat tttattgaga atttaaaaca 3334441 gcatattgaa atgaatcagt ctgaggataa aatccacgcg atgaacagct actaccgttc 3334501 cgtcgtctca acactagtgc aggaccagct gacgaaaaac gcagttgtcc tgaaacggat 3334561 tcagcattta gatgaagcat acaacaaagt caaacgtgga gaatcaaaat aaaccttccg 3334621 ctcacatgtg agcaggaagg ttttccttct ttgaggcgtg ctggatgaga cgggtgcttg 3334681 gcacgccttc catccaggta tgaaagtaat tggcgttttt cccgtaggaa ttatcaatga 3334741 ccgtgttttc tttttgaaga agagaagaca ggatgtggcc gtgcagcctt gatgtttcca 3334801 ccgattcgta acggctgaaa aaccgaatcg ctttttggac gatataatcc gagtattttt 3334861 cccatatata cgcaatgggc aaagggttgc ctgctttttt attcaagacg ttcagcgttt 3334921 ggagaaaagc aatcgtccgg cggtctgaag ctgacagcac cgtgcgccag tcgtagcttt 3334981 ccgcttctgc gtgttcctga agcgcctggt ttgcttcatg atctgttcgg ataaatctca 3335041 gcttttgatt ggacggctgc tgcgtgggaa tgacgggaaa cagctgatga gccatatcag 3335101 gcagaagctg aatgtgattt gttgtaaaat aggcctgtgc cgtagcatag gaggcttttt 3335161 cccttgtcat gatgtgaagg ttcgcatgct tagaaaatat ctctgccgtc cgcttgaggt 3335221 tgtctttgtt ttgaaaataa atcgattgcg gcaggatcac aattttgtgg ttcggatagg 3335281 tttggacgat tttctctcta aagccttgat aatacggata cagatccccg aagtttccgc 3335341 ctccctggca gacgatgatg agattcggat caagctttcg cccgattggg aaattgtctg 3335401 gattccagcg ttttctgacc cgaatcccgt gttctttaaa gaaggcttct gttcctttca 3335461 taataaataa atcccctaca ttcccatata gaggatagtc agcatatata atctctgatt 3335521 gtttcggaat gacgtcgagc agcccggaca gtttctgttt caggctgatc atcgaatgct 3335581 tgctgtccat ttcttcacct cgacagtatg gaataagtgc agtagcactt caatgacccg 3335641 gccttgctca tcttctgtca tattggaccc cgatgggaga cagattcctc gcttgaacaa 3335701 atcttcgcat acgcttcctg tatcttcatg agaataaaat aaagccggat cgaacagcgg 3335761 ctgggtatgg agcggcttcc acagcggacg ggcttcaatg ttttcttcag caagacgttg 3335821 aactatgtca tatgggctga gcccgttatc aagtgtgagc gtggtgagcc agcgattgga 3335881 tacgcctgct gcgtactctg gcataaagcg gacgccgtct aagtgaccga gcgcattttt 3335941 gtatctcgtg aaaatggtcc ttcttttctc cactcgctca tccagcacct caagctgggc 3336001 aatgccgacg ccggctaaga tattgctcag cctgtaatta tgtccaattt cactgtgctg 3336061 ataatgaaca gccggctctc gtgcctgcga agcgagaaat cttgcttttt caattgcggc 3336121 ttcatcattt gaaacgagca tccctccccc tgatgtggtg atgattttgt tcccgttaaa 3336181 tgaaaaaatg ccgaagcgcc cgaatgttcc gctttgcttc cctttataga ctgtgccgag 3336241 agattcggct gcgtcctcaa tgacaggaac tccgtatgca tcacacaggc ttacgatttc 3336301 atccattttc gcgctctgcc catatagatt gacggcaatt accgcttttg gcagtgttcc 3336361 gtttcttttc gcttcctcca atgctctttc aagggctgtc ggcgacatat tccacgtatc 3336421 aggctcagaa tcaataaaga cgggcaccgc tttttcatat agaatcggat tggcggttgc 3336481 tacaaatgtg aaggactggc aaaacacgct gtcaccttct tttacctcaa gcaaacgcag 3336541 cgcgagatga atcgccgccg ttcctgagcc gaccgcagct gctgctttta caccgactcg 3336601 ttctgccagc tgttcttcaa atgaattcac gagcggccca agcggcgcaa tccagtttga 3336661 gcgaaaggct tctgaaatat agtgctgctc cctgccgctc atatgagggg gagataagta 3336721 gattttttta tgcatagaat catcctttgt ttgatgtttg aatggaagaa atgatgcgtg 3336781 ccggagcacc ggccgccgtt accctgtccg gtatggaacg gatcaccgcg gagccggctc 3336841 cgacaatgct ccaagccccg attatgatct gcggtatgac ggatgcaccg gttccgacgt 3336901 gagcgccttc ctgaacggaa accgctcctg acagcgtggc acgcggggac agatgaacgt 3336961 aatcgctgat ttgattgtcg tgctctgcca ctgcacccgt attgatgatg cagtgggcgc 3337021 cgatgcgcgc atccgcctga atgatcgcgc ccgccataat cactgtccct tccccaatga 3337081 cagccgactt gctgacgatg gctgacgggt gaatcaatgt aataaaatca tctttcccca 3337141 gtcccagtcg ctccgccagc tgttttctga cactgttatt cccaacagca atcagaaaca 3337201 gcacatcagg aatgagcctg cgcagttcag taacggcttt cggcggtcct gtgtaccatt 3337261 cttttccgcc ttcgaacgtt ttgaatttat catccagcac cgcggctaag cgcgtatctg 3337321 agcgggcgtt tatcagctct ctgatcacct ttccgtgacc gccgtcaccc acaatggcca 3337381 catttttcat gaggacacat ctccgcttcc ggtaaaccgt tccgcggtca catgattggt 3337441 ttgctgaatc ccttctgaaa caaggacctt tcgcaccgtc aaacataaaa ttttcaaatc 3337501 gagaaaaaat gaccagttgt caacgtacca aacatctaat tcaaatttct tttcccagga 3337561 aatcgcgttt ctgccattga tttgcgccca gcctgtgata cccggcttca cctcatggcg 3337621 ccgtgcctgt ttttctgtat aaagaggcag atagtccatc aaaagcggcc gcggcccgac 3337681 aaggctcaga tcgcccttca ggacattcag gagctgcgga agctcatcaa tgctcagctt 3337741 tctgatcagc ctgcccgttt tcgtcagccg gacttcatca ggcagcagat ttcctttact 3337801 gtcccgttca tccgtcattg tccggaactt atatagggtg aacggtttgc cgtgcaggcc 3337861 cggccttact tgcttaaaga agacaggtga tcctattttc agcctgacaa cggcgatggt 3337921 gaacagaatg atcacacttg tacagcacaa caaaaaaatg gcggccgtca gatcaaaaag 3337981 tcgtttcagg atcaaagatt cacagctcct ttcgtttttc gaaaccgttt taataccagc 3338041 tgtctttcct cttttgtaca aacgagcata aaagcgaaaa cagcgtagca aaagctgact 3338101 gtcactcccg tcgctatcaa tgacggccag ctgtcaatct tcacaatgaa ctgaattgcc 3338161 ttacagaccg tccaggcaaa tacagcggct gaaagaggcc cgattatgcc tttaaggaac 3338221 acgtgctttt tgtagcctgt aatgcgggat acgtaaagcg gcgtaaagat ggcatttttt 3338281 aaaataagag aaatggcccc tgccaatgtt atgccgtaca gaccgagatg agccggcccg 3338341 ctcagcgtga ccgccagcac cacattcacc gcacctaaca gcagggtaac aatcgccggt 3338401 gttttttgtt gattaaaagc ggtccatata taaaacagcg gcataaaggc gaggctgaca 3338461 accaagtatc cggcatgaat aaataaaagc ggtgctatcg ttgaaaagga cggtccgagc 3338521 cagattgtca gaaaaggtcc cgccaatccg cccaataagg cagcaggaag tgcaagcaaa 3338581 agaccattga gccttactgc cttattggcg taattcatca atccttccat atcgcctttt 3338641 gaataatatg aagtcatgat gggcgcaaac agggatgcga ccgttccggc caagctgcgc 3338701 aaaagcagcg gaaactggat aatcgccgcg tatttcccgg atgcagacgc ccccagcatc 3338761 aaattggcgg ttaacagatc aatctgcaaa aaaagcagga cgccgatttg attgacggag 3338821 ctccatgcgc ccgcttgaaa cagctccttg cttgtacgga atgaaagatc cttcatacga 3338881 aacgaaaacc acggaatcag ctttttgaag aaatagaaag acagcacaga cgcaataaca 3338941 gcaccagcta aagctgcaag ctggatctgc cagattttcg gcgcaaagca tgcaaacagg 3339001 agcagcacag acagcacccg tataagcatt tgcaccgcct gaatggaact ggtgatataa 3339061 aggcggttgg cataaaatgg tgcagcgccg aagcccgcca tcagaaacgt taaaataaac 3339121 agcacactgc cgattaaaat cgacaaacgc acatctgcca aaagcgcttg cggcacattc 3339181 atgacgcggt caataaaaaa agccgaaccc gcaagcggca gcaagagcag caaggaaatc 3339241 aaaacagagg cggctaaata attgctgata tacgcatttg ctttctcccg ctctcccctg 3339301 tgggcagcaa cagaaaagaa ccgaacgaca accgagctga gcgccacggt aataaccgaa 3339361 aagtaattaa tcacattttg tgtcaagtga acaaagccaa acgcttcgac accgagcgtt 3339421 ttgacaataa aaggcgtcat ccaaaccgat aggaaaacag acaagagaaa agccgtgaga 3339481 ttcgcgctga aatttatcgt gaatttcatg cctgcttcgc actgcctttc attgtccccc 3339541 gctgctcgaa aaacagcttg atgagaaaag tgagccgcca tttacacagt gctaatacca 3339601 aacgctctcc tcttaataat ttctcatgct gaaacggtgt atgtctgaca gcctgccgca 3339661 ccatgtcata ggataaaatc tgtctgatct tctttttgat gtctttcggc gaattcggag 3339721 aagcacaggc atttgccaaa agcatcggaa gctggtgcct gcaaatgtac acattcaaat 3339781 cttctttaca tgcgcctgct aagccgtagt gattgtagaa tgcgatttta gcctgatatt 3339841 gtttttgaag atgttcatcc atcgccggct tataagggat ttctgtcagg ctgttcgggt 3339901 tttcacgata aatgtacaat ccttcatcaa gcattttcac ccgctccgct tcgcgaaaag 3339961 cggacaaatt aaagggagag tcttcagcaa aacggatgtc ttcatcaaac agcagattcg 3340021 ccctttcaaa aagctcacga cggtaaagat aacgccatac ataccagata aatctcgttt 3340081 cgtgagcatg tttaagctgt tcagtcattt ctggtttcgt cagcacgcgg tttgcctcaa 3340141 gctgcggcgg cacatatgtc cgcctgtccg atgactgctt gtaaaaaccg catccgacga 3340201 tgtcaagctg attttgctcc gcttcttcag tcagcctctg gaacatggcg gatgatacat 3340261 aatcgtctcc gtctacaaag ccgatgtaag tgccccgcgc ggcctttatt cccgtatttc 3340321 gcgctgaact aagcccgccg tttgcctgat gaatgacccg gattctcgca tcccgttttg 3340381 catagtcctc tgcaatttcg cctgaacgat ccggtgttcc gtcattcacg aggatgattt 3340441 caatatcaga aagcgtttga cgaagcaaag aatcaatgca ctcttctata aatggttcaa 3340501 cattatacat cgggacaata atgctgacga gcgggatcat tgcgcttcac cgctgatttt 3340561 gtcacgcaga cctttaaaat acacatctct cggaaagcct gcacgggatg tttcttttgt 3340621 taaaagctca ttgactgcgg ctgttacgcg ctctggctcc ggatgttcta tcagcttcat 3340681 gaacgggatg tctttaagcc attgatagcc ctccatcacc ttatggtcaa aggagcgaat 3340741 gacaacacac ggcgttcctg tcagcgcgca aaaaatcatg ccatgaagcc tgtcagtgac 3340801 gacggcttct gcgctttgca gcttagacca cagtgcttca agttcatgtt cgcgtgtatc 3340861 gcggctgacc cggcggccga tcgttgtcgt aaaggatttg atctcgccga attcctcaca 3340921 tagcgcagcc ttgacccggt tcctctgctc ctcctgaagc acgctttcct gatcctcgcg 3340981 caaacacata taaacccctt cgcgttctgc gggagccttg cttctgtcta aatacagcac 3341041 catgtccggc tgcttcaaaa ttgttttttc ttgaaaatgc tgtttcataa attgatacgt 3341101 tgtttcatcc cgcgccatca gcaataggcc ggggtgcgca ttataaattt tctgtgcccg 3341161 tttcagctct ttgcgccctt ttttcgtgtc agaaaaatga gccgttgccg gaagctggac 3341221 aacccgatag tcatggaatg ttttaatgat gaagcggcgc gtccactcct cataacggta 3341281 taaatccccc atgtttccgc cgccgatgat aaagaccata tcctccggat ggcgcgagcg 3341341 gatcaggctt tttgctgatt tgtaaatgtc cttcatatcg acctcgacga tgtcaaagtc 3341401 cgggtattct tgctcaagaa atgccttgct ggcataagca attgcgtgat ctcccaaatt 3341461 gtcatgggac ggcagcaggg tcagtatgat ttttttctga tgtgctgcgg cctttaccgg 3341521 ttgatctgcc gctcccagcc aatattggga cgggtatttg acctttagca gcagccattc 3341581 tgcaaaattg attttcaacg attgtaacga catgtcctca ccctctgttt ctcattttgt 3341641 actcgatcac ccgctgatac acagccgatg ccatagcgac gaacggaatc attctgtatt 3341701 tcgccatcag aagcaggcat gaccgttttg cgtcaaaagg agcagtaccc gtttttgaaa 3341761 gactttcttg aaacaccggg tccgcgcata tcacgccaac atttctaagc ttttcaaaca 3341821 gccggcggct gccgctcgtt ttccattcat tcagcataca gatgctgctg tgaagaacga 3341881 taaaggtatc aagctccttg cgatactcct ccagtttgtt gttctcctgt aaaaacgccg 3341941 cattcgtctc atacagcgca agtcctgatt caaacaattt tttctgatag cgctgcacaa 3342001 tggaggaaag gtgaattcga taatgataga gcggcgtttt tacgtaggat actgagcggg 3342061 cgaaaaaatg agccctgaag ctgaaaaact gatcctcgac atgctccagc tcgcctcgga 3342121 gcggaaacga cagccgatgg gcttcaatca tgcttcttct gtacagtttg ttccatgaaa 3342181 accctctgac cttcccttcg aataacgcct tgatatagtg ctccttcggc tgatcctgat 3342241 aggtttgggc aatgtcagag tccatggttt tgccagtgtc ctcaaactct gcggcgtaat 3342301 tgcaaatgac cagatcagtt tcatcgcctg ctgtccggag catctgctcg caataatcag 3342361 gctcaatcca atcgtctgaa tcgataaacg cgataaattc gccgcgtgca gcttcaatgc 3342421 ctttattccg aaccgcaccg agtccctggt tttcctgatg aatcaccttg aacctgttgt 3342481 ccattttggc gtattcttct gcgatatccg ggctggcgtc agctgaaccg tcattgacaa 3342541 tgatgatttc aatattgtcc attgtctggt tccgcagtga ttcgagacac gttctgatat 3342601 atgtttctgt gttataaaca gcgactaaca gactaaccgc aggtgtttcc ataatgaccg 3342661 gctcctcgtg cataaattac cgggaaaaaa tcgttctgta aggcagaacc gatgaatcga 3342721 ccggcataag caaataactg taaagaaaat aacaaacaac gatagcgata tagataagag 3342781 cgttcgattt ttcatcaaat atcctgacga aataagggac taggatcatt tgatacagac 3342841 cgaaataaat attgaatctg gcaaaaatca cgtcctttgt ggccaaaagg ccgaacaaaa 3342901 aacctagcag gcacaaattg acgacaatat caatttgcgg ccacagactc cgcagtcgtt 3342961 ctttatagca aaatgcaagg aacagcggca gaaccaaaac agcgattttg atcacattca 3343021 ttccatttgt gttcgtcatg agccattttt cataatggct gtatgagctg ttttcaagta 3343081 caacgacaaa cacagaaata aatttttgat ataaaaatgt catgccgaga aataaagcgg 3343141 ataggccgaa tatcgccggt gaccaggctt ttcttctgac aataaagtac actggaatca 3343201 taatcagcgc cgacgaatga aagagcgagc tgaccagcac aatcaggaaa tatcgcttcc 3343261 agttcccgct aatgatataa cggatcgccc aaaacaaaac agctgccacc atgtattgcc 3343321 tgatgccgtt aaaagatgcg taataatgaa aggttcccaa aaataaaaag acactcagct 3343381 caaacggcct gccatagtcg gcgagtgtct tcataataaa gctgtaggtc acgaccgcca 3343441 ccgtaaaata catgatttga ggatcttccg tgatgaaatt catcagccaa aggagtgcgg 3343501 taaaccccgg atctgtcgct gttttcgctg tgccgaaacc gaatatctgc cacacatttt 3343561 gataatcgcc cgccaattcg tacaacagcg tgtacgtctg aaaatccgtg ccgactcgat 3343621 agcggagacc tgacacgagc acaagtgaag cgagcggaat ccagatcaaa agcttattcg 3343681 gccgataccc cgtggcaagc gaatcatcac ggccgccgca cattttagcg aaccaagacc 3343741 aaataaatac aatccccata ttgacggcat atacaatcat cggttatggt ccttttccgt 3343801 gctgatgttg tatacattca gcagcgctcc tacattttgc tgtgcatcgt agccaagttg 3343861 agcgagtgtt tctttgatga actcacgctt cggcctgcct gcggcggccg cccttgcaat 3343921 ggtttcagcc cagacgctga tcggctcaga aagacttaat cttgtgacaa gcccgagacc 3343981 ggcgtcgact ttttctgtaa tgctgtctga aatgatgcat ggaagccccg acgcctgcgc 3344041 ttccacaagc acaaccggca agccttcgta cagagacggc atgacaaata catcgaatgt 3344101 tcgcatcagt tcatggatcc gttcttccgt gcctaaaaag aggacgtctg atagcaaatt 3344161 ctgctgccgc gcctcctcct ctatctcccc gcacaacggc ccgtctcccg ccagaacgag 3344221 ctgaaagcga atgcctcttt ccttgagatg tgcggcaagc ttcaacagga acgcgtggtt 3344281 tttcacttca tgaaaccggg ccacatggcc aatgatgagc cggtcggctg caatgccgcg 3344341 tgctgctttt tcttcatcag ccgcctgccc atttggggcg aacaactcaa ggtcaatccc 3344401 gttaggaaga aggtgaacac gctcccgctc catattggac tgtccaaata aaaacctgcc 3344461 cgcatcctct ccgcaggcac acagcgctgt cgcatttgcc aaaatgagcc gcctgaacac 3344521 gagcagctgc aatcgatcct tccagttgaa gccggtcttc caagacgtat tgtgggagtg 3344581 gcataccctg accggcactc cggcgagcct tgccgcaagg gcgataaaac ccgtttggaa 3344641 atccgtgtgc gcatgaacgg cgctgaacgg cccattttct tttatcgcgt ttctcacatt 3344701 cctcacaaat gtaaggggat tgctttgccc aatgctcggg acataaaaaa gccgcccgcc 3344761 taaagataaa atctcttcat cataagcgca cggatcattt cgatacgtta aaaaatcaaa 3344821 ttgcactttg cttttgtcca tcttccgata taaattcatt accatggttt ccgcgccgcc 3344881 cctgttcatg ccgctgagaa catggagcac gcgcttttgg ctgctattca tgcttgacaa 3344941 gcccttcctt ttggttcatc actctttttt tatggtagcg attcatcaca gctgcaggca 3345001 taaaggcgcg aattaacggt tttgcgatat atatgtaatc agataaagga agcttcaagc 3345061 gtctgcacgc ctgatagaca agaatggcat tgtcgattga atacgtaaat gaccgccgtt 3345121 tgaatgcatc gctgtcttcc ctcactttat acaaggcttc ctgaagatta tagcccctga 3345181 agccctcttc aaaaaagcga agccacaaat caatatcttc cattcgtctc gtccgccgca 3345241 ccgaccggta gcctttcagc gtgcggtagg cactcgctct catcataatc gtgccgtggc 3345301 aaaatggagt cccttttgcc atgatgcccg gctccggaac agaaggcaga atgcgggcgc 3345361 ctcttacgcc aaattcatca aacacaagca tgccggtgcc aaccacctga tagtgtcggt 3345421 gcttttctaa aaacgcgacc tgcttttcca gacggcgcgg aaacgaaagg tcatctccgt 3345481 cctgacgtgc gatataatcg cctgtcgcat gcgaaagaca atgatttaat gatgcggcaa 3345541 gccgcttatt tgttttgttt tgaatcagtt tgatgcggtc gctgtaatga gcggcatact 3345601 gcttcgcgat acggagcgtg ccgtctgttg acgcatcatc gcacaaaatc agctcccaat 3345661 ttttatagga ttggctgagt atggattcta tgctttctgc caaagtgcgt tcgcaattat 3345721 aaatgcccat aatgacagaa actttcggtc ctgagttcat acgcttttct cctttgtatc 3345781 catatccatg tacgcggaat aaatatctgc catttcttcc accgttcgcg cctccgagaa 3345841 gcgcaaggct gtttttcggc cttcctgtcc cagctttcgg cagagctccg gcttatggta 3345901 aagctgttca atccggcggg caaaagcagc actgtcaccg attttgatca gaaaaccgtt 3345961 ttctccgtcg cggatgattt cccgatgccc gcgattatct gtggcgatcg ccggttgttc 3346021 tgccgccatt ccctcaagca cattcatacc gaggccttct ctaatgctgg atgcgacaga 3346081 tacatccgca agctgaatca actcatgtat gtcgctgcaa aagccgtaaa aacagacatg 3346141 ggcggaggca ccaagctttt cagctaacgt ttgatacgta tgttccattg ccccttcccc 3346201 ggcaaacaca aggcggagtg agggaatttt ttcttttagc aaggctgcgg cttcaattaa 3346261 ctgcttctgg tttttgttca gattgagctc agccggataa accaatataa aatcatcttc 3346321 acggaacccg tgcttttctc tgagtctttg ctgctctatc ggactgacag gccggaaacg 3346381 ctcggtattg acgccaatgc cgtgaatttt ctgcgtcctt ccgcccggcc tttgaagtcc 3346441 tttcgcccgt atgtaatcct cttcattaat cgtaatcagg cagtctgtat atgctgaaag 3346501 ccatttctca accggatagt aaagaagcca atttttcatc ggtgcccctt tgcagaagtg 3346561 aaatccgtgc gctgtgtaca gcacctttgt tccgtgccgc cgtgcctgcc tcgccgccag 3346621 tctggcgaga acgccgccga ccggtgtatg gcaatggaca atgtcgtatt cataagtgtc 3346681 aatcactttc ttcagctgcc tataaacggc caggttctga gggtcaaaag gtgacctgcg 3346741 aatcgggatg gagaatttct catccacata cggcagcttg gtttgtccgt tcgcggcgac 3346801 atgaacctcc cagcccattt gcttgaacca tttaaaataa gggaggtgaa aggccttaaa 3346861 atgataatca acagtcgcgc aaaacaatat ctttttcgtc attttcactc cccctaatga 3346921 acgctggcag ccgtcatttc ttctgatgta ttgattgccg caaacagcct cgctctcagg 3346981 tcggcttccg gcagctcatg aaaatcctcg ataaagcgca tcagcaccgg ccaatcgccg 3347041 tccaccgctt taccgatgtg aatttttgga aagatttgtt cagcatggac ttcatttttg 3347101 ttcagcaatt cttcatacat tttttcgccc ggacgaatgc ctgtgaattc gattggaacc 3347161 tgctcagtcg tgtagccgga caaatgaatg aggtttttgg caagatccac aatctttacg 3347221 ggctctccca tatcgagaac gaaaatttga cgccctttcg ccagtgcccc agcctgaatc 3347281 acaagccttg atgcctcggg aatcgtcatg aaatagcggg tcattgccgg atgtgttact 3347341 gtcaccgggc cgcctttttc aatctgtttt ttgaaaattg gaatgacgct gccgcggctc 3347401 ccgagtacat tgccgaagcg aacagcaaca aatttggttc tgctgacttt cccaagattc 3347461 ataataatca tctctgcgaa tcgttttgtc gcccccatta cgttggctgg gttcaccgct 3347521 ttgtccgatg aaatcagcac gaatgtctca gttcccgaca tatcggctgc ttccgcgaca 3347581 ttttttgttc cgataatatt gtttttgacc gcctcttctg gattgtgttc cattaaaggc 3347641 acatgcttat gggcagctgc atgatagaca acatgcggct cgtatttttt catcaaggta 3347701 aacattttat cgcggtcctg cacatcagcg atttccgtat ggaacacaat gtgtttgccg 3347761 aatcgtccgt tcagctctgt ataaatcgaa tgaatgctgt tttccccatg gccgagcaga 3347821 atgatttcct taggctgaaa cgcgctgatc tgacggcaga tttccgagcc gattgatccg 3347881 cccgctcccg tgacgagaac tgtttttcct ttgatgcggt tcgaaatttc gctagtgtcg 3347941 agggttaccg gctttctgcc gagcaagtcc tcagctttta catctctgat ttgtccggca 3348001 gttcgtgtgc caagcagcat ttcatcaaaa tgaggcataa ttttaatgct tactccggtt 3348061 cgcacacatt ctttatataa cacctgaagc tcatgggtgc ggagtgaagg aatggcaata 3348121 ataatataat taattttgag cttttgcacc gcaggcatga tactttcttt tccgccgatt 3348181 acgggcagcc ccataatttc taatttatgc ttcgtttggt cgtcatcaat aaaagcgaca 3348241 ggtatgatat caggttcatc tttcgaaagc agctgcctga ccatcagagt cccacctgag 3348301 cccgccccga taatcagcgc gcgggacgag gcgcagcgtt ttttcctgat gctttcgttt 3348361 aatactctgg ataaaatacg ggtccctcca atagacaaaa gctgaagcac ccagcacgcg 3348421 gttaacagac ggaagaacat cgtgtgatac acagcatact gaatgacgcc ggtcacagcg 3348481 gctgaaagcg taatgccctt aagcaggaca atcagctcgc caagcccggt gtatgtccac 3348541 acctgtttat actgattgaa caggaaagca cacacatgat agctgaggag caagctgaca 3348601 gcggtaagca gtaatgctcc ggagtcataa aattgatagg aatcttttaa aaattgatat 3348661 cctgcaataa ctgaatttaa aacgaggtaa gtatccagcg caataatcat tgacagtctt 3348721 ctccggtaac tcaacctttt cccccctaat tcttttatcg gtttagctgc ggcggttttc 3348781 gtctctccaa aaaatcggca gcagctaaac cgacaatacg tcctatgtat atatgagata 3348841 agtgggcatt taacccatcc tcacgccccg ccagcgacga ccagcatcta aggcagcaac 3348901 ttcagctgcc cacagcagag ccgagtgcct ccattgatac aggtcaggag acatcacctt 3348961 tacaaaaact agtaggaata gtgttccgat tttttcattt tctttttgtt taaaagagcg 3349021 cctaacagct tcgcattgga ttgttccagt gcatcttttg ctttcagaac ggtatcggtt 3349081 tttgtttttc cgcttaaaac gacgagcacg ctgccgtctg tctgatttgc tagaatctga 3349141 gcatctgcaa cagccaaaag aggaggggaa tcaaagatga cgaggctgaa ttgttcatag 3349201 atctcagata ttaaatctcc cattgctttt gaagacaaca gttctgccgg gtttggcggg 3349261 gtcggcccgc ttgtcagtac atataagtta tcgatcggcg tcttttgcac cgtctcactg 3349321 agtgaagcat tgccgaccag cacatttgtc agcccggtta cattatcaac ctgaaacgtc 3349381 tgattgatgg tcggctttct taaatcggca tccaccagca gtactttctt ttcctgctgc 3349441 tgcgcaaaga cagccgcaag attcgctgca ctgaacgatt taccttcacc aggcacagag 3349501 gaggtgacga ggatagatcg caagttggtc tggacagatg agaactcaat gtttgtccga 3349561 atggtgcgat attgttccgc aacaactgat ttattgtgta aaacagatat ttgagccaaa 3349621 cctcgccttg ctttcttttt tctaaagatc actcgcttca ctccccgaaa tgttttatcc 3349681 cgcgattccg ccctttgtgg acatcaggaa cggagcctaa gcatggcaat ccggttctct 3349741 cgctgagctg ccgtgcgctt ttgcatgtat catcgagaaa atgcagaaaa aatgccagtg 3349801 taatgccgcc catgacagca gcgccaaaag ccatgaccat atttcgcagc ctggccggct 3349861 tgatcatcgg gctttccgaa gccttcgcct ctgataatat atgtacgcct tgtacattca 3349921 ttctttcatc tacttctttt tcaaacttgt tcactaacgt gttcgcaatc tcagctgctt 3349981 tcgccggatc gtgatcctga acggcaacgt tgattatttc tgattcattt tcactgctgg 3350041 taaccacttt tcctttcagc gaggaagccg attcagatag gtgcaattcc gccttaactt 3350101 cttccatcaa ggcagtgctt ttcataatcg attggaacgt gctgctatac tgaagatttc 3350161 gctggatgtc actgagattc gagttttctt caccgtctga ttcatgaacc agcacctgtg 3350221 tcgacgcctg gtaggtcggt gaaatgacct taaattgcac aaaacccata ataagggtga 3350281 cgccgattgt gatgagcaga atcagcacga atctgtgtct gacaatcgca tataattctt 3350341 tgaaactcat attctcattc atgtattcat agccttcagc cttcccgcgg ctggcttccc 3350401 gcgccccttt ctgttaatga ttggattata aaagaaaacg ttattattta aaaattgcaa 3350461 aataagccaa taagttctct ttagagaaca aaatcatgat tttcctctaa tttactgcac 3350521 ttcccttatt attttaaatt ttataaagaa cgaaaaattc cttataatga acgaaataac 3350581 gacaggaata gaggagaatt tcatattatg attggaagaa ttatccgttt gtaccgtaaa 3350641 agaaaaggct attctattaa tcagctggct gttgagtcag gcgtatccaa atcctattta 3350701 agcaagattg aaagaggcgt tcacacgaat ccgtccgttc aatttttaaa aaaagtttct 3350761 gccacactgg aagttgaatt aacagaatta tttgacgcag aaacaatgat gtatgaaaaa 3350821 atcagcggcg gtgaagaaga atggcgcgta catttagtgc aagccgtaca agccgggatg 3350881 gaaaaggaag aattgttcac ttttacgaac agactcaaga aagaacagcc tgaaactgcc 3350941 tcttaccgca accgcaaact gacggaatcc aatatagaag aatggaaagc gctgatggcg 3351001 gaggcaagag aaatcggctt gtctgtccat gaagtcaaat cctttttaaa aacaaaggga 3351061 agatgatgat cggttaaagg gctaacgttc gcatctatag gggaaatctg tttataatgg 3351121 gggaaaaagg gagagaacac aatgactcat caaatagtaa cgactcaata cggcaaagta 3351181 aaaggcacaa cggaaaacgg cgtacataag tggaaaggca tcccctatgc caagccgcct 3351241 gtcggacaat ggcgttttaa agcacctgag ccgcctgaag tgtgggaaga tgtgcttgat 3351301 gccacagcgt acggctctat ttgcccgcag ccgtctgatt tgctgtcact ttcgtatact 3351361 gagctgcccc gccagtccga ggattgcttg tatgtcaatg tatttgcgcc tgacacccca 3351421 agtaaaaatc ttcctgtcat ggtgtggatt cacggaggcg ctttttatct aggagcgggc 3351481 agtgagccat tgtatgacgg atcaaaactt gcggcacagg gagaagtcat tgtcgttaca 3351541 ttgaactatc ggctggggcc gtttggcttt ttgcacttgt cttcatttaa tgaggcgtat 3351601 tctgataacc ttgggctttt agaccaagcc gccgcgctga aatgggtgcg agagaatatt 3351661 tcagcgtttg gcggtgatcc cgataacgta acagtatttg gagaatccgc cggcgggatg 3351721 agcattgccg cgctgcttgc tatgcctgcg gcaaaaggcc tgttccagaa agcaatcatg 3351781 gaaagcggcg cttctcgaac gatgacgaaa gaacaagcgg cgagcacctc ggcagccttt 3351841 ttacaggtcc ttgggattaa cgagggccaa ctggataaat tgcatacggt ttctgcggaa 3351901 gatttgctaa aagcggctga tcagcttcgg attgcagaaa aagaaaatat ctttcagctg 3351961 ttcttccagc ccgcccttga tccgaaaacg ctgcctgaag aaccagaaaa agcgatcgca 3352021 gaaggggctg cttccggtat tccgctatta attggaacaa cccgtgatga aggatattta 3352081 tttttcaccc cggattcaga cgttcattct caggaaacgc ttgatgcagc gctcgagtat 3352141 ttactaggga agccgctggc agagaaagtt gccgatttgt atccgcgttc tctggaaagc 3352201 caaattcata tgatgactga tttattattt tggcgccctg ccgtcgccta tgcatccgca 3352261 cagtctcatt acgcccctgt ctggatgtac aggttcgatt ggcacccgaa gaagccgccg 3352321 tacaataaag cgtttcacgc attagagctt ccttttgtct ttggaaatct ggacggattg 3352381 gaacgaatgg caaaagcgga gattacggat gaggtgaaac agctttctca cacgatacaa 3352441 tcagcgtgga tcacgttcgc caaaacagga aacccaagca ccgaagctgt gaattggcct 3352501 gcgtatcatg aagaaacgag agagacgctg attttagact cagagattac gatcgaaaac 3352561 gatcccgaat ctgaaaaaag gcagaagcta ttcccttcaa aaggagaata aatatgggga 3352621 aaacaggata cattggtgct gccattgttg tggcagcttg tatcattatt ttgtcggccg 3352681 tggtatgttt acgggacaca gtctattacc agcctatgcg ctggactggc atcatactgt 3352741 ttttcgcggg aattgtgatg gttcccgcat actcagcaaa aagaaaaccc ggaaaagaga 3352801 agtaattctc ttttccgggt ttttatgttt attataatct tcccgcgcga atatcgtctg 3352861 tcattccctc ataaggagcc ttcgaaatca cttcttcgtt gtcgactcct tcatttttca 3352921 gaaatgtaat ttccgcaaat tcaggtacaa cgtattttgg atacgtttca tatttttcgc 3352981 gggattcttt catcaaatca atgtggtcat tttggtagca aaccgtaatt tcaggatgtt 3353041 catgcaccca tttcgggaag aaaataatgc catgcatgcg tttttcattt ggcataaagt 3353101 ttaatgaaac atccgtgcca gtcggctctg tccaagacac tttatatacg ccttctgtca 3353161 gtttgacaat attcacttcc tgatctcgaa cccagcgtcc ggcaaccatt ccgctatgaa 3353221 ttctataatc aattgtatgg tcgtttttaa tataaatctc gtattcccat ccgttttcat 3353281 acgtataaat catgtggctt ccgataaagt tttccatctt acacactctc cttagtcttt 3353341 tactgtactt cataaatgtc tagtagaacg taatcagggg ttctttctgc ggaaccgata 3353401 aacaagcggt catggagcca ttgatagact tcactgcctg tttcaaacgt cggtaccgta 3353461 cgaaaataaa catgctccgg ttcaataatt tccccggctg ccgcttgttt tcgaaacggc 3353521 ttgctgactt gccgtattcc attgttttca atgtaaatca gttcatgatc tgctgtttca 3353581 atcacatacc tggcagataa atctgttctg ccgttagcgc gaatcatttg tgaatcggca 3353641 ccgcccggca aaatacgtcc ctttacttcc ccggttattg ttcccgaacg aatcggaatg 3353701 aatcatctca gtcccaggct tgtctcacca atcgtgatag gcggatcaac cttgatttct 3353761 aaagaggcga atggttttaa aaccggcttc ttcacgagaa ccacctcacc ttcagaaaaa 3353821 atcatgtaac tatttacatg ttcactttaa caccattgca gttaactgtc aaacaatagg 3353881 aacataaaaa aacaaggact gtttgaagac agtccttgtc tgaagctagc tttgataagc 3353941 aagatatgtg ctgacagtgc ttttggcaag acaggcagag gaatctataa tcggaatctc 3354001 actttgaata tgatctaaca ccgcatttaa atccgtgcag gctgaaatga tgatgtctgc 3354061 atgctgactg atttcttcat atagcgtctg ccacaatgct tgtgtatgct gcatatgatt 3354121 tggctgtttg attgcggcga taagctggtt cacagcctgc tgccaatggt ccttgtgaat 3354181 aacttcttgt ccatttccct tcagaacttt ttggtagatg gcggattgga tggttggctc 3354241 tgttcctaaa accaccgctt tttttgcggg atgcggaatc tcttttatcg tttcctcaac 3354301 aatatgcaac ataggaactg acaatgcctg ctgaatctct tcatagtaga catgcgccgt 3354361 attacaaggc agcgcaatga aatccacgcc tgttttctcg agctttaccg ctccgtcgat 3354421 aatcgctttt ttcatctcgt catggtcaat tggacgatct gcatagaagg gcgtcgggca 3354481 tgaatagatc atcatgtgcg gatagtcaat atcgtttgaa gccccataca gcttctgaca 3354541 gtaatcaatc accttatcaa taaacggcga ggtcgatttc ggccccattc cggctaatat 3354601 tccgatcatc aaattcattc ctttctactt cgtacggacc gcttcttcct ctgagccatc 3354661 ctcatagagg ataaagcttt tcgcagcatc ctcacctaat gtaaactcga cttcaacaga 3354721 caatgctcgc agaaagaaac gggtttccga ggaaggaaat aactccagtc tcagctgtcc 3354781 ggcgatctcc aaataaagcc gttcattctc ggttgtcacc tgtgcagccg tcccatcctg 3354841 caacaggtag ctgccaacat agcggctgta tatcgccgta tcaattgctt ttttcttttt 3354901 atcagcagga cgttccggga catcatatgg ctggccaaat agaatatgtt ccgccgcctt 3354961 cagaatcgct tgttcatatt cagtatcctc ttccttatta ctcaaataga tcagcgtttt 3355021 acgatgatcg atatatcgga tcatcatcgt cgaatagccg ggccatcctc cgctgtggct 3355081 gacaatccgc cctttttcag gactgttttg cagcacccag ccaaagccat aatcaattgt 3355141 ttctccattg ttgaggcgca ctggagaaaa cgcagattcc ttagaagcct tgctgatgaa 3355201 atcgtcctga tataaagcct gatcaaatcg aaacaaatcg cttgtgacag agttaaccgt 3355261 cccatctccc tgtatgccat cgagatacac aacatagttc gtttcctcca gctcatcagg 3355321 gaggacgtat gtttcggaat gtacatcata cacatatcca tatgcataat gatcaattcg 3355381 ctcaggcgaa agcctcctgt tatacactct tgtttcattc atgcctgccg gtaaaaaaat 3355441 acttgttttt ataaaatccg catagctcat gccagatgct ttttcaatga taaccgccag 3355501 cagcacatac cccgtattgc tgtacatcca gccttcattc ggttcaaaat aaccagatag 3355561 cccctcattc atcagcatat cgacaatatc ctgattcacc gcaatcttgt gtgaatccca 3355621 attggcaaaa aaccatccca tataatcagg aagccctgac gtatggttca ataaatgccg 3355681 aatcgttacg ccctgatacg gaaaaccggg cagccagcga tccactttat cctcatagcc 3355741 aagaatcccc ttctcctcca gcaagatgat tcccaatgct gtaaaaggct ttgacaaaga 3355801 cgctaactca aacaaagagt tggttttcaa cgggcgtttt tccgtcattt ccgcatagcc 3355861 aaaagagtgg tgatataaaa tatcgccacc ctccgcagcc agaaccgtcc cgttaaactg 3355921 atgtttttcg cctaatgtct caaataacgt ctgaagatgc tttcttttat tctgcttcat 3355981 tcctccacct cccatatctc tgtacgttac taacctacta acgtttcaaa tattttgaaa 3356041 aatccttcag ttagagatcc tttttaaccc atcacatata cctgccgttc actattattt 3356101 agtgaaatga gatattatga tattttctga attgtgatta aaaaggcaac tttatgccca 3356161 tgcaacagaa actataaaaa atacagagaa tgaaaagaaa cagatagatt ttttagttct 3356221 ttaggcccgt agtctgcaaa tccttttatg attttctatc aaacaaaaga ggaaaataga 3356281 ccagttgcaa tccaaacgag agtctaatag aatgaggtcg aaaagtaaat cgcgcgggtt 3356341 tgttactgat aaagcaggca agacctaaaa tgtgtaaagg gcaaagtgta tactttggcg 3356401 tcacccctta catattttag gtcttttttt attgtgcgta actaacttgc catcttcaaa 3356461 caggagggct ggaagaagca gaccgctaac acagtacata aaaaaggaga catgaacgat 3356521 gaacatcaaa aagtttgcaa aacaagcaac agtattaacc tttactaccg cactgctggc 3356581 aggaggcgca actcaagcgt ttgcgaaaga aacgaaccaa aagccatata aggaaacata 3356641 cggcatttcc catattacac gccatgatat gctgcaaatc cctgaacagc aaaaaaatga 3356701 aaaatatcaa gttcctgaat tcgattcgtc cacaattaaa aatatctctt ctgcaaaagg 3356761 cctggacgtt tgggacagct ggccattaca aaacgctgac ggcactgtcg caaactatca 3356821 cggctaccac atcgtctttg cattagccgg agatcctaaa aatgcggatg acacatcgat 3356881 ttacatgttc tatcaaaaag tcggcgaaac ttctattgac agctggaaaa acgctggccg 3356941 cgtctttaaa gacagcgaca aattcgatgc aaatgattct atcctaaaag accaaacaca 3357001 agaatggtca ggttcagcca catttacatc tgacggaaaa atccgtttat tctacactga 3357061 tttctccggt aaacattacg gcaaacaaac actgacaact gcacaagtta acgtatcagc 3357121 atcagacagc tctttgaaca tcaacggtgt agaggattat aaatcaatct ttgacggtga 3357181 cggaaaaacg tatcaaaatg tacagcagtt catcgatgaa ggcaactaca gctcaggcga 3357241 caaccatacg ctgagagatc ctcactacgt agaagataaa ggccacaaat acttagtatt 3357301 tgaagcaaac actggaactg aagatggcta ccaaggcgaa gaatctttat ttaacaaagc 3357361 atactatggc aaaagcacat cattcttccg tcaagaaagt caaaaacttc tgcaaagcga 3357421 taaaaaacgc acggctgagt tagcaaacgg cgctctcggt atgattgagc taaacgatga 3357481 ttacacactg aaaaaagtga tgaaaccgct gattgcatct aacacagtaa cagatgaaat 3357541 tgaacgcgcg aacgtcttta aaatgaacgg caaatggtac ctgttcactg actcccgcgg 3357601 atcaaaaatg acgattgacg gcattacgtc taacgatatt tacatgcttg gttatgtttc 3357661 taattcttta actggcccat acaagccgct gaacaaaact ggccttgtgt taaaaatgga 3357721 tcttgatcct aacgatgtaa cctttactta ctcacacttc gctgtacctc aagcgaaagg 3357781 aaacaatgtc gtgattacaa gctatatgac aaacagagga ttctacgcag acaaacaatc 3357841 aacgtttgcg ccaagcttcc tgctgaacat caaaggcaag aaaacatctg ttgtcaaaga 3357901 cagcatcctt gaacaaggac aattaacagt taacaaataa aaacgcaaaa gaaaatgccg 3357961 atatcctatt ggcattttct tttatttctt atcaacataa aggtgaatcc catatgaact 3358021 atataaaagc aggcaaatgg ctaaccgtat tcctaacctt tttaggaata ttgctgttta 3358081 tcgacttatt tccaaaagaa gaacatgacc aaaaaacaaa atcaaaacag aagccggact 3358141 accgggcggc atatcatttt acgacgccgg ataaatggaa aaatgaccct caaaaaccga 3358201 tctattttga tggcaagtat cattatttct atctatataa ccgggattac ccaaaaggca 3358261 acggcacaga atggcgccat gccgtctcag aggatttggt gcactggacc gatgaaggcg 3358321 tggcgattcc gaaatataca aacccggacg gtgatatttg gaccggttcc gtcgtggtgg 3358381 ataaagagaa cacagccggc ttcgggaaaa atgcgcttgt cgcgattgtg acacagccct 3358441 cagccaaaga caaaaaacag gaacaatatt tgtggtacag cacagataag ggaaaatcat 3358501 tcaaattcta cagtggcaac cccgttatgc ctaatccggg cacagacgat ttcagagatc 3358561 cgaaagtcat atgggatgac caagataaca aatgggtcat ggtcatggct gaaggatcaa 3358621 aaatcggctt ttatgaatcc gataatctta aggactggca ttacacaagc ggattcttcc 3358681 cagaacaggc gggaatggtg gaatgtcccg acctctacat gatgcgggca agcgacggaa 3358741 cgaataagtg ggttctcggt gccagcgcga atggcaaacc gtggggcaaa ccaaatacgt 3358801 acgcctactg gaccggaagc ttcgacggaa aagaattcaa agcggatcag actgaagccc 3358861 aatggcttga ctatggcttc gactggtatg gcggtgtgac gttcgaagac agcaaaagca 3358921 cagatccatt agaaaagcgg tatgcgcttg cctggatgaa caattgggat tatgccaaca 3358981 acaccccgac aatgaagaac ggctttaacg gcacagattc tgtcatacgc gaactccggc 3359041 tgaaggagca ggatggaaca tacagcctcg tctcacagcc gattgaagct ttggagcagc 3359101 tgactgtttc aactgacgaa atagaggatc aggatgtgaa cggatcaaaa acattgtcga 3359161 taacaggtga tacgtaccag cttgatacgg atctttcttg gtcagagcta aagaatgcag 3359221 gcgtcaggct cagagaatca gaagaccaaa aacgccatat tgatgtcggc attttcgctg 3359281 aaggcggcta tgcttatgtc aatagagcag ccacaaatca gcctgacaaa agcaatacct 3359341 atgtcgaaag caaagctcct tatgatgtaa acaaacgtaa ggtgcatttg aaaatacttg 3359401 tcgataaaac aacgatagaa gtatttgttg gcgacgggaa aaccgttttt tcaaatgaag 3359461 tcttcccaaa gcctgaagat aaaggaatta ccctttattc tgacggcggc acagcctcct 3359521 tcaaaaatat aacagtgaaa cactttgatt cgattcatga ataaaaacag gggcggcgca 3359581 ggctgcccct gtttttttat taggagcggt attctctgtt acatattggg cattgtaagg 3359641 aatataaggc tggtttcaaa ggaggaagcg aatgtctaaa caaggaaatt ttcaaaaatc 3359701 aatgtcgctg tttgatctga ttttgattgg gatgggagcc atctttggat cagcgtggct 3359761 gttcgctgtc agtaatgtcg cttcaaaagc agggccctcc ggcgcttttt cctggatcct 3359821 cggaggagcc attattttgt taatcgggct tgtatatgcg gagctcggag ccgctctgcc 3359881 ccgtaccgga ggcatcattc gataccccgt ttattcacat ggccaccttg tcggctactt 3359941 aatttcgttt gtcacgattg tcgcttatac aagcttgatt tcaattgaag tgacagctgt 3360001 gcgccagtat gtggcctatt ggtttcccgg cctgaccatt aaagggtctg attcgcctac 3360061 catttccggc tggatcttgc agtttgccct attatgcttg tttttcctgc tgaattattg 3360121 gagcgtcaaa accttcgcta aggcgaattt catcatatcg atttttaaat atattgtgcc 3360181 gattaccatc attattgtgc tgatctttca ttttcagccg gagaatttat ccgttcaagg 3360241 atttgcaccg tttggattta caggtattca ggctgccatc tcgacaggcg gcgtcatgtt 3360301 tgcgtatctc ggcctgcatc cgattgtatc tgtagcaggt gaagtccaaa atccaaaacg 3360361 caatatcccg atcgctttaa tcatttgcat catcgtttca accatcattt atactgtttt 3360421 gcaggtcacc tttattggtg caatcccgac agaaacactg aaacatggct ggccggcaat 3360481 tggccgggag ttctcattgc cgtttaagga tattgcggtc atgctcgggt taggctggct 3360541 tgcaacgctt gtcattttag acgccattct gtctcccgga ggaaacggga atatctttat 3360601 gaatacgaca tcccgccttg tttacgcctg ggcgcgtaac ggcacattat ttggcatatt 3360661 ctcaaaggtc aataaagata cggggacacc ccgcgcttcg ctttggcttt cgtttgccct 3360721 gtccattttc tggacacttc cctttccttc gtggaacgcg ctcgtcaatg tctgttcagt 3360781 cgcgctcatt ctttcatatg cgattgcacc catttcttca gctgcgctga gggtcaacgc 3360841 gaaggactta aacaggccgt tttatttaaa gggaatgagc attatcgggc cgctttcctt 3360901 tatatttaca gcgtttatcg tgtactggtc aggatggaaa acagtctcct ggctgctcgg 3360961 ttcacaactc gtgatgtttt tgatctatct ctgtttcagc aaatatacgc ctaaagaaga 3361021 tgtcagcctt gctcagcagc tgaaatcagc ctggtggctt atcgggtttt atattatgat 3361081 gctgatcttt tcctacatcg gttctttcgg acatggttta gggattatca gcaatcccgt 3361141 cgacctcatt ttagtcgcga tcggctcact tgcgatttat tactgggcaa agtataccgg 3361201 gctcccaaaa gccgccattg attatgataa ataaagaagc aagaggtttt cttgcttctt 3361261 tattctttac aaacaaacat acacgcgata aaatgaatga gagtcagtca ttactggagg 3361321 tgttcctcat gccaaaacaa acatcgggta aatacgaaaa aatattgcag gcggccatag 3361381 aagtcatttc tgaaaaaggc ctcgacaaag cttctatttc tgatattgtc aaaaaggccg 3361441 gcactgccca aggaacattc tatttgtatt tttcatctaa aaatgccctc ataccggcca 3361501 ttgcagaaaa tctcctcacc catacacttg atcaaatcaa aggtaggctc catggggacg 3361561 aggatttttg gaccgtttta gatatattaa ttgatgagac atttctcatt acagaacgcc 3361621 ataaggatat tattgtcctc tgttattccg ggcttgcgat cgaccactcc atggaaaaat 3361681 gggagacgat ctatcagcct tattattcct ggcttgaaaa aatcatcaac aaggccattg 3361741 caaaccatga ggtaacggaa ggaatcaatt caaaatggac ggccagaacg attatcaact 3361801 tggtcgagaa tactgcggaa cgattctata tcggatttga acaagatgaa aatgttgaag 3361861 tgtataaaaa ggaaattttc actttcttaa aacggagctt aggtactgct taaaaaatga 3361921 ctgggtaaca ccgctcattt tttaatgccc taaaaatgac tgacgttcat tcataaaata 3361981 gagaggtgtt tcatttgaat tgggttcttg tttttattgc agggctttta gaggttgttt 3362041 gggcctcttc cctcaaacat gccgattcgc ttttggattg gatcatcatt tttatcttaa 3362101 tcgcggtcag ctttatcctg ttgatccgct cttatcaaaa aatcccgatg gccgcggcgt 3362161 acactgtgtt tgtgggaatc ggaaccgtcg gaacatatct gactggaatt gttctgggcg 3362221 aatccttctc agcagcccaa atgttctttt tagctttatt gctggctggc attttaggaa 3362281 tgaaattatt tacgaaagaa agcaaatctc agccgggagg tgaaaaataa tggcatggtt 3362341 tttattagtg attgccggca tagaagaaat tatagctgcc attgccatga aatatataga 3362401 cggaacaaga aaaaaatggc cgatcattgt gatgactgtt ggattcggct tatcctttta 3362461 ctgcctgtcc caagcgatga tcgtcctgcc tgccggagtc gcatatgccg tctggactgg 3362521 cattggaagc attggtgttt cggcggtcgg gctcatctgg tttaaggagc ggtttcagct 3362581 ttcacaggtg atttcacttt gccttatcct agccggcgtc atcggcctgc gtcttacgtc 3362641 atcttcataa aatcaaggca tatacagctg tatatgcctt tgccattaag cttcgtgatg 3362701 tttttgaaga tgaagcggcg gcgggatgag ccagcctttg ttttttagca gccttaagta 3362761 ttttgcgccg gttgccgctt tcgacatatg aaattgccca aacatcatgg caatatcctc 3362821 acgaatcgat tgccccatca ttttgctgca tgtcacaaga cctgcagcat tttctgctgc 3362881 cgcggaagcc gccacatccg gatcgagaaa ccgtgcacca ggcggaatat cgttaagatc 3362941 tgctgtcggc ggttcaggag aagccggcgg cagcgccacc ccgttttctt tcaggatcgt 3363001 gctgacctgt ttgatttcat cttggcattt ctcaatagac tcacgaagca gcttcttcag 3363061 gtcgtcatca ccgacatgat tcaatagcat ttggtaattg ccgaccattt tattgcccgc 3363121 catcacataa ctccacaagc cgaatacctc accgtaatgc atcggttcat cctgcggatt 3363181 tccgcttaaa atacccatgc tcattctcct cccatattca atattgcaca tttcataacg 3363241 tgcccaagcg gaggaacatt tatgtttcag cggaaaagat ttatgaaatg aaacaaaaca 3363301 aaaaagacaa gagtggcaag ttgccaaacc attgtctttc ctgttgtttg attggacgca 3363361 ctgaagggat tcgcaccccg acagacaaga taccggaaac cattcaagtg ctttttagta 3363421 tgagtcattg attctgtctt taataaactt taacgagatg gcgggatgct ttgcggaaaa 3363481 cgaaatacat tttcggggtc atatttcgcc tttatttctc gaagccgcgc aaagtttgcg 3363541 ccataatatt cttttccgaa gttttcaatg ttttgatctg gaacattaac atatgaacct 3363601 gctacatatg gttgcatcag ctgacgcact ctttcaactg atgcaagatt tgaatcttct 3363661 tgtgatttat ttttccaact agccgtccat tccgtataaa ataatggatg gcgccaaaaa 3363721 aaggcagttt cgtctttagg gactctgctt atagcaccac cccaattgat aaaaaagaaa 3363781 ttggcttctg ttccagtagc atcttccaaa aattttctca tgattgaaat gggttcgtca 3363841 gaccaaaaat catgacccca tgccgaggag aatttaacac tctgatcatt tctgccaggg 3363901 atgggttcgt cagggtctaa gaaatctata gcatctggat agtataatgt tttgatatct 3363961 gcttctgttg gagttcccgc atgtaataaa ggttttaata atcgaatcaa ttcagttttc 3364021 gaaccgagga aaattccttc tgcatgacac aaaccattta ttttgctgta aatttcaagg 3364081 tagcatccta atcgttcatc tacaaacgga gcccatttct gccaagcttt aaataccgtt 3364141 tctaattgtt cccacggcca gataatattg aagacggttg cagttttagg ggcacgatga 3364201 actttgaatg tatattgggt attatatcca aagttacctc ctcctccgcc tctagaagcc 3364261 catagcaaat cctcattgtg agattgatct gcgtgaataa tccttccttt tgcatctacc 3364321 gttttcagcg cgagaaggtt atcacttata aggccaatcg atcgtgagag tacaccaaat 3364381 ccgccgccca tcgtaattcc cccgattcca actgttgggc tatctccaaa cggagccata 3364441 aaaccgtctc gagctaatcc ctttacaagc gggccaacgg gaataccagt ttgaacggtt 3364501 gcaatagcgt tttcttcatc taagaaaact ttattcatgt cactcacatc aataacaatt 3364561 cctccactta ctactgaaag gttcttatct aaagcatggc gaccgcttct gacacgtaag 3364621 ggcactttat tctcacgagc ccatttaatg gcattactta catcgtatga attttgcgca 3364681 aaaacaaaga caagaggata gacatccaca taagggttcc aattcttaat agcctctgta 3364741 tagccggggt ctcctttgaa gattacacgc cctgtcaact gtgttgatcc catatattat 3364801 ttcactccca aagaaattcg attcagatac taaaatatgc aggagctgga taatcgcata 3364861 gacaaatgat ctacgaacta taaatataat acgctaaggc ctttttcgtc ggtgaggtct 3364921 gctgagaaac atttttcaaa caattttgag caaacttcct gtccaatcct ccaacaagcg 3364981 ttttttctta tcgtttttag gagcagtgtc cagttttttt cggagtgaat attcgtttag 3365041 gccaaaagaa aagagagatg aagaagtgtt tagtaccaga ggtatacatc catacaacag 3365101 actctagatc atcatatact gaatgtatgt agaaaggaga catcagcttt ggcaaaatat 3365161 cggattatga cctttgacgg cggcggtacc ttaggtgctt taagtttaca actattaaac 3365221 agattggcta ggcaaaaccc gaagttaatt agtcgaaccc atgtattttc gggaaattca 3365281 atcggttcat ttactgccct tgcattagca agcggaagat ctccgaggga aacacttcag 3365341 tattttgagg atgaaatcct acccgcattc agcatttccc ggccaggcgg acctgttttc 3365401 aaccaacaat taccctattc cggttttatt aaagcggtaa gaaatttttt cccagcagat 3365461 cttcaactta tagatttaag aaaacgaatt gttgtcccat cattcaaatt atactctcaa 3365521 aaactggacc gttggactcc tgtcttattt cacaattttc ccggctctcc ctatttaaat 3365581 gaaaaagtga gtgatgtcat actgcggagc agcggtgctc ccgcgacgca acgcgcctat 3365641 caaaactatg tggacggata tgtagtagca acgaatccca gtacagccag tatcgcgttt 3365701 gcagttggta aagccaacgt gccattggat caaattgcgg tattgtccat cggaacaggt 3365761 gaagccccga ctcggttaag aagagatacg aggggatggg gaatggtaag tgcagataac 3365821 atacgtcccg aaaatctgaa gaaccttcct ccaaattggg gagtcctttt ggacaggtcg 3365881 cctaatgaac ctttactgcc atttcttcag atgattgctg gcggtaatgg gtactatgaa 3365941 tccatggtca gtgcgaatct tctgggagat cgttttttcc ggttagatcc gcggattccg 3366001 aacttctcca aaacggaccc tgccgtcgtt cccgctgtca ttgaaattgc gaacaaaaca 3366061 aacttacagc ctgcgaatca atttatagag aagaactggg ggagcaaata attatttatt 3366121 ttaaatcaat tctcgcttat acaattttgt ccgagagaag attctcaaaa taaatacagg 3366181 caatgggtag aaccggattt ttttaaaggt ttgttaatca caagctaata agatgaatga 3366241 aaaaatcaat tcatacttct tcttttgaaa gtgagggttc aaactaaaga atgtaattga 3366301 aatgttactc taaggtatgc aattcccttt ttcacacaaa aaaagacaag agcggcaaat 3366361 cgccaaaccc ttgtctttcc tgttgttcta ttggacgcgc tcggagggat tcgaaccccc 3366421 gacagacgtg gtaccggaaa ccaccgctct atccaactga gctacgagcg catatagact 3366481 gcgttatgag aacgtcagca caactaatta tacgataatt cctttcaaat aacaaccctc 3366541 tatttcgaga ggccgttttt taaatagaca aagcatctta attggcaatc tgacatacga 3366601 tggtttgaac ccctgtattt ttggggaaaa tgggaaaaag agacgacttt gcatatcagg 3366661 ccagcttttt gtttgacctt tattgaccaa aaatgtatca tgtaactaca tacttaccta 3366721 aaaggtgaag gaggagcatt atgaatttaa tacctacagt cattgaacaa acgaaccgcg 3366781 gggaaagagc gtatgacatt tattctcgtc tattaaagga tcgtatcatc atgcttggat 3366841 ctgcgattga tgacaacgtt gcgaactcca tcgtgtcaca gcttttattc ttagcagcag 3366901 aagaccctga aaaagaaatt tctctttaca tcaacagccc gggcggctct attacagccg 3366961 gtatggcgat ctatgatacc atgcagttta ttaagccgaa ggtatctaca atttgtatcg 3367021 gtatggctgc gtcaatgggc gcgttcctgc ttgcagccgg cgaaaaaggc aaacgctatg 3367081 cgcttccaaa cagtgaagtc atgattcacc agcctcttgg cggtgcgcaa ggtcaagcga 3367141 cagaaattga aattgctgcg aaacgcattc tcttgcttcg cgacaaatta aacaaagtcc 3367201 tagctgaacg tactggccag ccgcttgaag tgatcgaacg cgacacagac cgtgataact 3367261 tcaagtctgc tgaagaagcg cttgaatacg gcctgattga caaaattttg actcacacag 3367321 aagacaaaaa gtaataacac aacctgcaag agctgcgtct cttgcaggtt tttttcattt 3367381 caaggaattg actcccttat tctatactgc tcccattcct catgtaacag ctcaagcgtc 3367441 aaatcactcg tctgcctcac aaccagatca gcaccaagca tcggctgtcc ttgaccgaca 3367501 ccaaccgcaa acatccccgc agatttgatt gcagaaatgc ctgcttctgc gtcttctatt 3367561 gccgcgcaat cagcagggga aacatcgagc atcgctgcag ctgttaaaaa gatgtcagga 3367621 tcaggcttcc ccttcgcaag agtcgtcgga tcaacaatgg catgaaaatc atcgataatt 3367681 gccaagcgtc ttaaaatctt aggagcattg cgacttgaag atgctaaccc gatttttata 3367741 ttttcgtttt tcaattgaca tagaagcctg ccaatccccg gtaaaagatc ttccggcgtc 3367801 aatttgctga tcagcatttg ataatcgcga tttttccgat gcataagctc ttgtttctcc 3367861 gcatttgtat actttgtttc cgccccgcca aagatcaata tgctttcaag tgactcttct 3367921 ctgctgattc cttttagcct ttcattcatg tctctgtcaa aagggatatc gatttgttct 3367981 gcgatgtgct tccaagcgag aaaatgatat tcagcagtat ctgttatcac tccgtctaaa 3368041 tcaaaaatga ccgctttcat atactaatgc ccatcacagc ttcataaggt ttgaggctaa 3368101 tactctttaa gtcagcccgc tcctgcggat agtttgaaat tagcactttc caacgctcat 3368161 gaatcagttc tggaggcgct tcgaacagag ccttttcttc cgataaattc acaacgacaa 3368221 gaagcttttc ccctcgatat tctcgaaggt aagaaaagac ctgcggatca ttctcctgca 3368281 acagctgata atcgccatat atcataatct tatattgctt tcgtaattga atgagcttct 3368341 gatagtaaaa gaaaatcgaa tcttgatctt ccaaagactc tttcacattg atatcttgat 3368401 agcgggaatt taccggtatc cacgggtctc cggctgtgaa tcccgcatgt tttccggcat 3368461 cccactgcat cggtgttctc gcatgatccc ttccttttat catcacggct ttgacaaact 3368521 ctttttctga catcgttttg ttttcgacga ctagttcacg atatgcattc tttatttcaa 3368581 gatcatcata catctccagc ggcatatcgc tgttgaccat gccgatttct tctccctggt 3368641 aaataaacgg cgttcctttc atgccgtgca gaaccgttgc aaatgccttc gcacattcct 3368701 tacgcagttt cctgtcattg ccccagcggg aaataaccct cggctggtca tggttctcaa 3368761 aataaagggt attccagccg acattcatta acccggtctg ccaccttgtc atcgtctttt 3368821 ttaaagcaat caaatcaaac ggcttgatct gccatttccc atttggcgag ttttgttctt 3368881 tatcaatatc catatgttca aatgtaaaga tcatattcag ctcttgcctg cttgcatctg 3368941 tgtacttttt cgcctcttca atatcagagc cgtttgcctc tccgactgtc atgcagtcgt 3369001 aatgagaaag cacttccctg ttcatctctt gaataaactc atgaagacgt gggccgttag 3369061 agtgataacg gccgacaata tagctgcggc tgtgatccgt ttcgtagtcc ggaaaatcgg 3369121 tgtatttaga aatagagcca atcacatcca tccgccagcc gtcaacgcct ctatccatcc 3369181 agaatctcat tacatcataa acttcccggc gaacggcttc gttttcccaa tttaaatcag 3369241 gctgtttttt cgaaaagtag tgcaaataat actgccctgt tccttcatcg tatgtccacg 3369301 ctgagcctga aaagatcgat ccccaattat tcggctctga gccgtccggt ttaggatctt 3369361 tccaaagata ataatcccgg taaggattgt ccttcgactt gcggctttca gcaaaccaag 3369421 catgctcatc tgatgtgtgg ttcacgacca aatccatgac gattttcatt ccgcgtttat 3369481 ggacttcatc aatcagctga aacatatctt catttgtccc aaacttttcg tacatgtttt 3369541 tgtaatcgct gatatcatat ccgttgtcat cctgcgggga atcaaatacc ggggagagcc 3369601 agatgacatc cgccccgagg tttttgatgt aatccagctt ttgaatcaca ccttgcaaat 3369661 ctccgaatcc atctccattg gcatcataaa aactgcgcgg gtaaatttga taaacgacag 3369721 cttctttcca ccattcactc attaggcgtt ctcctttcac atcgtccctg taggacaacc 3369781 ggttcctcat aaacgttcat gtgcagcggc tcgcctttta caagctcaaa aataacgcgc 3369841 ttttcgtcaa ccgtcacatt gattaatcga tttcgataat tgatgttgaa tgaatattcg 3369901 tcccattctt tcggcaaaaa cggagcaaat gacagcgtct cattcgcggt gcgcatgcct 3369961 gcaaagccat gaacgattgc cagccagcta cccgtcattg aagtaatatg caagccttct 3370021 tccgtatcat gattgtaatt atcaagatca agccttgctg tgcgcttata taattcgagc 3370081 gctttctttt ccagcttgag ttcggctgcg agaatcgcat ggacagaggg cgataggctt 3370141 gattcatgaa cagtcatcgg ctcataaaat tcaaaatttc gccgtttttc ttccattgta 3370201 aaacggtcat taaaaagata aatgccttgg agaacatctg cctgcttaat aaaattggag 3370261 cggagaatct tgtcccatga ccaattctgg taaagaggcc gttccgctgg atctaattcg 3370321 tcaactgttt gcaggtcttt gtccaagaac gtgtcatgct gaacgaaaat ttgcagttct 3370381 tcactaaatg gatagtacat gtgctggatg atttctctcc agacttccaa ttctacttcc 3370441 tgcacatcca gatggcggcg tttctccgct gagatacttt cgagactttg tagagtatac 3370501 tccaacgtcc aagccgcaat gacattcgta taccaattgt tgttaacgtt gttttcgtat 3370561 tcattcggcc ctgtgacgcc atggatcata tacttatttt ttcgtttcga gaagtgaaca 3370621 cggtcggccc aaaatctgct gactgccaca agtacgtcta tcccgtattc ttccatatag 3370681 ttacggtcgc ctgtataatt gatataattg tagatcgcat aacagatcgc gccattgcgg 3370741 tgaatttctt caaaggtgat ttcccattcg ttgtggcatt catcacctgt gaacgtcacc 3370801 atcggataaa gtgccccctt catccccaat tttgcagcgt ttcgtttggc agcctccaac 3370861 tgatgatagc gatacaaaag caggtttttc gtcacctccg gctcggctgt cgccaaatac 3370921 atcggaacgg cgtacgcctc agtatcccaa tatgcggcac ctccatattt ctcgccagta 3370981 aatcctttcg gcccgatatt caaacgggca tcgcccccgt aatatgtcga gaataactga 3371041 aagatattgt agcggattcc ttgttgaagc tcctcatctc ctttaatctc aatgtccgct 3371101 tttgcccatc tttccttcca tcgatcagtg tgcctccgtt ttgcatcttc atagccgttc 3371161 tctaccacat ccgccaaaag ctccttggct ttcgataaaa gctcttcctc ccgaaaatca 3371221 cgggaagtcg tgacaatcac aaactttttc aatgatgcct tcgtttgata actgtagcga 3371281 ttctcgacat acatttcagt cgttttaaag ctttcatgga caaaaccctc cgtctcgttt 3371341 gccattgcgg ctaataccgt gaagcgcggt gttccaaatg gattttcgat cgtttttgcc 3371401 gctaaatggc cgctgtgaga atcagcacct ttcgcttcct cctgccaaaa ctgttcttgg 3371461 tagttagaat cttcatttgc cacatttcca tccaggtaag gaacaagcgt aatgacagca 3371521 tctcccgtca agcactccgc ttcataatga atcgcacaga gttcttttac agcaaggcta 3371581 agaaaccgct ctgacctgat tctgacggtt ttatcttgaa tgcggacaac agcgcttcgc 3371641 cgcagaatcc cctctttcat attgagttct acctcaaata attcgattgg gttttgatgg 3371701 agatcgattt tttcaccgtc aacatatagg cctatgccca taaagttcat cgcattgatc 3371761 acttttccga aatattctgg atacccgttt ttccaccagc ctactcgcgt tttgtcgggg 3371821 aaccacacgc ctgcaatata tgtgccttgg tgactgtcgc ctgaatagcc ttcttcaaaa 3371881 ttccctctga cccccatata gccattggca agagacgtca ggctttccag cagccgtgta 3371941 tgctccttat taaatgtatt tgttttgatt ttccattcat caatctcaaa taaccgctga 3372001 tttatcatca tttcctcccg aatgtaagtt tccattatca cggcgggttt tggtcaaata 3372061 tctaaatgca aaagagatca tcaaagtaac gccacacgaa tggatcatca atacagtaat 3372121 caaatcaaaa tgaaccatgc cgatagcagc tgccgcaaat gccggcagtg ctgatgcgca 3372181 aatcgctata gaggccgctt ccttgaatga tgcaatagag accatgtttg atatttttgt 3372241 gatccagagg ccacctgcaa gaacaaacgt taacaaaagc tggatcatag aaaccaccgt 3372301 atatgccagc atcatgatca tcggcttata ctgtgccaac cacaatgtat cgatcaagac 3372361 ctctacatca tggacgtttg gtttctcgag cttaacgtcc attttcgcat agccaacaga 3372421 aaaccccgtt tcgttttgat cggtgatcac cagttgatca ggttgaaata tgatggcgtt 3372481 ttcaaatcca gttactttca atcgcccatt ttcaccgctt gtctcatatt catgcttcat 3372541 atcgactgcc atcacattct gcccatcttc aatcctctca gagctcttcc cgcctgttag 3372601 ttttccgttc ctgatttgaa aaccctgcaa ttgatcagca aattgatcat taactccttg 3372661 aatcgctgac ggcatgaaag atgaaacgct gaagcgatcc attttcacaa acgaaaccgc 3372721 taacggcgcc attaagcagg ccgttaaaaa cagaaagaga aaagagagct gcagccagct 3372781 gaaggtattc ccatagcggc aaacacctga tggggatgca gccgccttca ggcagcggat 3372841 gataaagctt ttattctcca gattcttcat tggcattacc cctttgttcc gccggctgtc 3372901 aaaccggaca caaagttctt ttggagaaaa aagaatagaa cgcatatcgg cagtgcggct 3372961 agtatggcac cggctgcaaa tagagctact ttttgctgct gcggattaga aataaaggat 3373021 tgtaatccta cagcgatggt cagcctttcc ggtgagcgaa gcagaaattt cgtcagcaaa 3373081 tagtcgccaa acggtgccat aaacgcccaa agcgcttgta ccgcgagcat tggcttaaca 3373141 agcggtagaa caattgaagc gaaaatcctc agatgtcccg ctccgtcaat tcgcgcggct 3373201 tcatcaattt ctctcggcac agtatcaaaa taacctttca tcagccacgt gttcatcgga 3373261 attccgccgc cgatatagat cgctgttaaa aaccagtatt gatcgagtgc gcctattagc 3373321 atcgccaaga cataaaaagc agtcagcgcc gccattgtcg gcaccatttg aatgattaaa 3373381 aagaatatca ggctcttttt tctgcctgca aaccgatagc ggctgtacga gtacccggca 3373441 agtgtcacaa tcgtaacctg caaaaccatg accgatagcg cgatgacaag tgtattgctg 3373501 taccaattga gataaagcgt ttcgtcaaat agccgcttaa aatgatccaa tgtccaagaa 3373561 cccgaaaaat cgagctgaaa agccgccgaa ttccccacac ggaaggctga tgatgccgta 3373621 atcagcaacg gatatataat gacaatactt aaaagcgtca aaaataaata cgtacagatt 3373681 ttattaagca ttctggcagt gctcgcgttc acctacataa cctcctcatt gccaaaagca 3373741 ttcgattttt tgaaagcaat cagtgaaatt ccaatgacaa tgaaagaaat taacagtgtc 3373801 acagccgccg caacggaata ttggggtgat gtgcctgttg tcagtttata aatccacgaa 3373861 attaagatat cggtcgatcc ggccccggct cccgcactgc ctggccctcc ctcattaaat 3373921 aaatagatga tcgagaaatt attgaaatta aacgtatact gagtaatcat cacgggtgct 3373981 gtggcaaata aaatcatcgg gaatgtaata tgccgaaaac gctgaataaa agtggccccg 3374041 tcaatctttg ccgcttcata caattcacct ggaatcgcct gaagcactcc cgttaccatg 3374101 acatatatat atggaaagcc gagccacgtt tgaatcataa tgagggctgt ctttgtccag 3374161 aaaggatcgg tcttccacgc gatcgcaggc agctcgacaa acggcaggtg attgaataat 3374221 ggtatcacct gtgcattcac cgctcctatg ctgtcgttaa acatgttgga aaaactcatg 3374281 attgtaataa acgccggaac agcccatgga aataagaaaa tcattcgaaa tatccgcttg 3374341 ccttttataa aatcctgatt gacgaaaagt gccgtcacaa tacctaaaat gatttgcagc 3374401 gttgttgcac agattgtcca gataaccgtc cagcccagta cattcacaaa tgtttcacga 3374461 taggagccaa ggaaaaaaat atttaagaaa tttttaaacc cgacccagtc aatcagacga 3374521 ttaggcggaa tatgataaaa atcatagttt gttaatgcaa caaacagagt caccaaaacc 3374581 ggaaaaataa tcacaaacac catcatgata tatgccggca gtgtaaatag atacggaaaa 3374641 cctttatcgc ccgcatgaca gatcatatcc ttggctgttg tattgacttc caaacccgcc 3374701 gctttcatag cggcggtctt acgtgaatca tgaatattaa agatatagaa catgaggaaa 3374761 atcattgtca cgatcaattg cagcgtgcct tcaatcagca taaacagcga gtgatcttca 3374821 ccgggaacac ttcccaatgt catcaatccg gttagcgcct gtataccgaa aacgcataat 3374881 tcaaaagcaa acaagcctgt gatggcaaga aataagagcc cctttgacaa ctgctgattc 3374941 gcaatctgcc caagtcctgg aatgatcgat aaaagccctg cctttcgttt ttgctttgta 3375001 agtgtgtgat gtttattcat ttttccgccc tctattcttc cggacgctat cccgccgttt 3375061 tatttcacat acttttcttt aatattttcc tttatgacgt ttacagcatc attcgctgat 3375121 gtttgtgtcg atttttttcc tgaagctgca tcaaaaatta aactttccgc tcctgtccat 3375181 acttcagcca tttccggaat atttggagtc ggcgttgctg tttcatattg tttaatcaca 3375241 gctgacgtca gttcattctt ttgctcatcg gctttcttcc ttgcagccgt gttggccgga 3375301 acttcgtttg tatcctcata aaaagcgtaa gcattggcat catttgcagc atactcaagc 3375361 catttttcag ccagctcggg ctcttttgta tatttcgagg caacccagcc cttcccgcca 3375421 gcaaaagggg cgtattcttc tccatttggc aatgtcggaa tgggagccgc tccgtagttc 3375481 aatttagcct ctttatagtt ggcagctgac caaggaccgc caatgatcgc agccgctttg 3375541 ccttctaaaa acatctgctg aataaagtcg tctgcgcttg aattgtcttg cattcctttc 3375601 ggccaatatg tctcaaacca tttctccgca tatttcaccg cttctacagc ccctttattg 3375661 ttcaggccga tgtccccgga atctgtgccg ttttttccaa acacatatcc gccgtatcca 3375721 gccaataagc cgtacgacat ataaaagtca gtccattttg ctaaaaatcc ggttgatttt 3375781 cctttttccg aagcaaacgc gaatcgagga tcttccgtta acttttcaag gtctttaaat 3375841 gtttttggcg ctgtttttaa aagatctttg ttgtaataca aaataagtgt ctcaatgact 3375901 agcggcattc cgtacacttt gccgtcaact gtcacctgct gcatttcttt atcaccaaag 3375961 ctttttgtgt tagatggctt aatatcaagt aaatgtcctt gttgtcccaa accgccgatc 3376021 cggtcatatg cagcaagcat aacatcaggc gcattacccg ccgggccatc aagaggaagc 3376081 gcttctaact gttcgaacat ttgcttttca acaattttta ctgtgacatc attttctttt 3376141 tcgaactttg tttttatgct ttcaatgtat tctttatacg tttcttcgac agacacagtc 3376201 agcacctttt tgccatcaga gcttgctgga ttttttgaac ttgagcaggc ggcaaggccg 3376261 attgccagga atgatgccgc caatatggcg aacccctttt ttaaaagaac catctctttt 3376321 cctccttcta tttacgaaac tataacaatt gtattgtcct atagaaagcg gttacaacaa 3376381 ctttcgattt gttaccgata acagaatgtt atacaggggc ggcagcactc aaaatcaaaa 3376441 attctcccgg ctgaacggca atgacatcgt gatgctgtag cggctgctct gtccatgcat 3376501 cacagatttt cttattccta tcaatattca actctcgtaa actgacgtgt tgaaccacat 3376561 tcccttgatt aaagaaataa atcagtattt tttcatcaag agtccgcgaa aagctaatga 3376621 aatcattttt gtcgtccagc agattccact caagatgtcc ttcagtcaat aaagtgtttt 3376681 cctgcttgcg taaagcaatt aaccgtttca taaattgcag catgtcttgg ttttgcttct 3376741 ctttttccca aaccatacat ttccggcata atggatcatt ttcgccgttc agcccgattt 3376801 ccgttccgta ataaatgcat ggtgagcctg tctgggcaaa cataaaggcc agcaacgcgc 3376861 gtgctttctt ctcatcattg cggcatctgg tcaaaaggcg ctttgtatca tggctatcca 3376921 gtaaattaaa catcacctca ttggcctgct tcattccatt catcaaatgt gcattgacac 3376981 ggtgagccat acgtgaagct gagatcgtct ggtcagcaaa gtattcaatc ataggctctg 3377041 taaaagggta attcatcgcc gcatgaaatt catcccctct aagccagggt tcggcagaat 3377101 gccagatctc acctaaaata taaacatcag gcttttcagt agatacagcc tgcctaaatg 3377161 tcttccaaaa aacgtgatcc acttcatttg cgacatccaa acgccagccg tcaatgtcaa 3377221 attcgcgaat ccagtacaaa gcaatatcaa gcaaatattt ctgcacctcg ggattagccg 3377281 tgtttagctt cggcatatca gctgtaaaag caaatctgtc ataattgtcg tctgtgacgg 3377341 gaaaagagtg aatatggaac cagtccttat agcgggattg atctccgttt ttgacgacat 3377401 cctgccattg cggagacgcg cttcctatat ggttaaaaac cgcatcaagc ataattctca 3377461 tcccccgctg atgcagctgg ctgaccaatg tacgaaaaag ctcaggatcc ccgaaatgcg 3377521 gatcaataga aaagtaatcc agcgtgtcgt atttatgatt agaaggcgcg gaaaagatcg 3377581 gtgtcagata aatgccgttc acccctaaat cctctaaata atcaagcttg tcaacaattc 3377641 cttgtaaatc ccctccaaaa aaatcattga cgtccgggtc cttgctcccc cacggcaatg 3377701 cattcttcgg tgacaagtct tctcttccat ttgcaaaacg ctccggaaaa atttgatacc 3377761 aaaccgttga cttgacccat tcaggcgctt gaaatgtatc agcctcgtga acaaacggaa 3377821 atttaaagta ataatgaatc gtttccagtg ttttttcgtt ataagggcat acacccgaac 3377881 ttccgaaaaa gatgtcttca tgatcgtctg ttacaacaaa cgcatattgt aaacgcctaa 3377941 atggcggcac cacttcagca aaccaatagt catgcatttc tgtagcagca attttcctca 3378001 tcggctgctc gtttgccgac catttgccgt cgttgtactc atagggatca ccccaaatga 3378061 atcgaatgtg atctgcatca ccttttttcg tccgaatctt gatatgcaca gtccgcccat 3378121 cataagaata agcatctgtg ctgaatggct ggtgatgaat cgctgcatat tccatcatgt 3378181 ttcccccttt gatttccgtt ttattgaagc cggctcatag tttgaaagta tcatgatgaa 3378241 attgtgggaa caatcctttt caccctgtta ccgataacag aataaggcgc ttacagcgtt 3378301 gattctcgta caattaactc tggttcaaaa aatagacttc cttgtgcagc gccgtcttca 3378361 ttcatttttt tcagcaacat tttcgcacag gcttccccca tttcaacaac aggctgtctg 3378421 accgtagtca agcgcggcga ggagatgcga tcaagaaaca caccgtcatt cccggtaacc 3378481 gcaacgtctt ctggaattcg ctttccaagg gattgcgccg cacgaatgac gccgagcgcg 3378541 attcgatcag atgcgcagac aaatgcggcc tgattgtcca tggatttcag cagttctctt 3378601 gcaaggcatt cacttttctt agaactgttg tcgatccgaa acatattcga ttttttaaag 3378661 cttttattca tcgcccgtat atacccctgt tctcttgcac gttcgaaagg ctcatctaaa 3378721 tcaatgccaa aaaagacaac ttcccgctcc cccagcccca taacatggcg ggttgccata 3378781 aaagtgcctt tctcgttatt cacatcgata aagtcatagc ccatttcatt ttgtccaaat 3378841 acgacgagcg gcttctcaaa agcttttatt acaccttcaa aatcgttctt tctcaagccg 3378901 gtggcaataa tgccgtcaca ttggccaata ttaagagaat ttcttgtcac aagctggaga 3378961 gcatagtgat tgcgatccag ctccctgctg attcctgtca gcaggttcat gtaatatggt 3379021 tctgtcgtat ccatttcctc aagtatcaat agtttcacaa cctgtgttct gttttgcacg 3379081 agcgctctcg ccgcataatt agggatgtaa ttcagctctt tcatcgcaga atgaacaagc 3379141 tttttcaatt catccgtcac cgtctcaggg tgattgatca ctcgtgatac cgtcattttc 3379201 gaaacatttg cttttttcgc cacatctgac aatgttgcca ttttcatccc ctccttatct 3379261 gtgcttatta tccaaactag tgataaagtc ctctattact gctaaatata cgatgcaggc 3379321 caaagagaaa taaaaaagag atttccctta aggaaacctc actttgttaa aaacactcga 3379381 tttttcatgg attcatacgc taggtggcag actcattctc tccacttcca tcagaaaatc 3379441 tcttttttaa atttctgtcc actttttttc taaaatcgga taagaataat tttgcatttg 3379501 ctcaattaac tcatccggcc gtgacgagct gtgaatcagt tttaggtgcg attcgttaga 3379561 aaacccttct tgaatgctgt atttcaccat tttcatcatt ggttcaaaat atccgtttac 3379621 attgtacagt ccaattggct tttggtggat gccgatctgt gcccagcaca gcacttcaaa 3379681 taattcttca tatgtaccga agccgcccgg catcgagata aagccgtccg ccagctcgct 3379741 cattttagcc tttcgttcat gcatcccgtt tacttcaatc agctcagtca gattctgatg 3379801 gacaacctcc ccgctgaaca aaccgctcgg catgaccccg attgcagttc cgccgttttc 3379861 cataatcgcg tcagcaatcg tgcccatcaa gcctacgcgg gagcccccat agacaaggcc 3379921 gattccctgc tcagccatat acacgccaag ctctgccgct tttcttttat acgcttcatt 3379981 tcccccaggg tttgatcccg caaatacaca aatggttttc atcttgtcat ctccgcatct 3380041 atatatcgtg ttaaacattc aaaaacacac tatatattgt cccatcttca tgtgataata 3380101 tcaatatgaa atacataaag aatgcaggag tgatgaggtt gcagctggct gatgcagaaa 3380161 aatggatgaa agagttttac gaaaaaagag gctggacaga atacggacct tttattcgcg 3380221 tcggcttttt aatggaggaa gccggagaac tggcccgggc tgtcagggcg tatgaaatcg 3380281 gcagagaccg gccggatgag aaagaatcgt cacgcgctga gcaaaaacaa gaattgattg 3380341 aagaaatggg agatgtcatc ggaaatatcg ccattcttgc tgatatgtat ggtgtctctt 3380401 tagaagacgt catgaaggcc caccaagaaa aactgacaaa acgatttgag catgcataaa 3380461 aaagcggccg cgatggccgc tttttttaac ctgtgatttc atcatggtga tcaaagaaat 3380521 gctgctttcc tattttgtga aaaaggcctg ttttatgcag tagctccttc ggctgcgatt 3380581 gcaatcctac aatcatcagc tttccattgt ggcgtttaat tcgattcata atgttcccaa 3380641 gcaccgcttc agctgacgta tccatatagt gcaccttatt catgagcaga ataagggttt 3380701 tcggtttttt ctgtacatgc tccagcaatg acgattcaag ggaatcaatt gatccgaaaa 3380761 acagcggccc ttctatggca tacatgctga cagatggatc ttctctcttc gccagaacag 3380821 gatgcgtttc ctgattgtgg atgcgggtcg cttcgctcat tcttctgata aagaacacga 3380881 atgcaagcag caatccggtt gccacaccga tgattaagtc aaacagaacc gtaagggcga 3380941 aggtcgccgc caaaataaag gaatcagcat ttttcagtct cagcatgttt gcgacttcct 3381001 tgcgctcact catattccat gcgaccacca tgagaatcgg tgccatactg gcgagcggca 3381061 catgggacgc ataaggcgca aatacaagca ggacaaggag aacgactacg ccgtgaacga 3381121 cgccggaaac tggggaaacc gctccgtttt ttatattggt cgccgttctc gcaatcgctc 3381181 ctgtagccgg gattccgcca aacaggggcg ctgccatatt cgcaatcccc tggccgacaa 3381241 gctccttgtt gctgtcatgc tttgagccct tcatgttatc agcgaccatt gcggacaaaa 3381301 tcgactcaag tcctccaaga agcgcgatga caagcgcagc cggaaacagc ataaccattt 3381361 tatccaaagt aagctcagga aactgaaatt ccggcaaatg gcgggggatt tctccataag 3381421 ttgacccgat cgttgccatg cggtcaggga aaaagacaac cgcgaccact gtggaaataa 3381481 gaagcgccaa caaagcgccc ggcactttag gcatcacctt ggcggataca agcaaaatga 3381541 cgagcccgat cacagctgtc aaaatggcat acacgttaaa ggtgccgagc tgctgcacaa 3381601 tttcaaacat gttgtgatga aagttctcat gtttttcaac atttctcaat ccgagaaaat 3381661 tagcgatttg ttccgtaaag atcagcacgg caattccggc tgtaaaaccg acgataacgg 3381721 gtttgggcac gaatttcatt atttttccga gcttaaacag cccaaacagt accagcatca 3381781 ctcctgccat aaaccccgca atcagcagat tttccaagcc gtactgcatg ataatgccga 3381841 ataaaatcgg gacaaaggcg cccgtcggac cgccaatctg atattttgat cctccaaaca 3381901 aagaaataca aatccctgct ataacaacag tgtatagccc atattcaggc tcgactcccg 3381961 aggcaatggc aaacgccatt cctaaaggaa ttgccacgac acctactacg atacctgcaa 3382021 tcaagtcttt ctgaaatttc tgcaaattgt atcccttgaa tctccctgag aatcgcatat 3382081 tttgttataa cctcccttat gagtgattgt ttataagctc agtttcataa ccgttaatga 3382141 ccacatcaag ttttcctgtt tcagggtgaa tgacaagccc gtgaaccggc acttttttcg 3382201 gaagcagcgg atggttctta atcatgttca cactgtggga aacgctttct tccacgctgt 3382261 gaaaaccagt cagccacgtt ttcaaatcga gtccggcact cgtcagcaaa ttcaggcagc 3382321 tatcctccac cccgcgttcc tttgctttct caagaatcga ggacgcattc agccctgaca 3382381 ttccgcattc atgatggccg acaatgcata cctcttcagc ctgcaattca taaatcgcga 3382441 ccagtatgct tcgcatcacg cttccaaatg ggtgagaaac gatggctccc gcgtttttta 3382501 caattttagc atcaccgttt ttaagcccca ttgcttgcgg aagaagttct gtaagccttg 3382561 tatccataca ggtgacaatg acgagctttt tcgaaggaaa ctttgtcgtt ttgtacggtt 3382621 catacttctt ctcactgaca aaccgctgat tgtgttccaa aattgatgtt aaagaaacca 3382681 tttgattcat ctcccatcca tatgattttg caagccttct tacccagctt acagtaagga 3382741 attatagcat aggaataagc caagaaaagg ttttcaaaaa aagacactat aattggactg 3382801 tagaatcaaa acataaacat ttatatcttt caaagataat aaaatttata tttaatgcat 3382861 cctataatcc ggctgcagtt cgtatatcga tgatttgtct gacaaaaaat atgggtgaat 3382921 tctgataatt aaaaaacttt tttaagcaga tttagctgtt cgatcttcat tttaagttca 3382981 aaagaaccag aaattaaaaa aacgcagcta tatttttaac atctatttat tttcgatata 3383041 atgaattaga caacagccat aaagggggag ccttgttgaa accatttgta tttatcacaa 3383101 aaccgattcc tgaagagatt gaagcattca tcggtgaaca ttgccgttat gaagtatggc 3383161 aggaggatac gcttccgagt gacgtgctat ttgaaaaatt aaaagaagcg gaggggcttt 3383221 taacatcagg gacgtccgga ccgtcaatca atcgtgagtt gctggaacac gcgcctaagc 3383281 tcaaagtggt cagcaaccaa tcagtaggct acgataactt cgatatagaa gcaatgaaag 3383341 aaagaggagt cgtcgggact catacacctt atacactgga tgacacagtt gcagatctgg 3383401 ctttttcact gattctgtct tccgccagac gtgttgccga actggaccgt tttgtcagag 3383461 caggaaaatg gggaaccgtg gaagaggaag cgcttttcgg aattgatgtt catcatcaaa 3383521 cgttaggcat tatcggcatg ggcagaattg gagaacaagc agcgagacgc gccaaatttg 3383581 gttttgatat ggaagtgctt tatcataacc gacatcgcaa acaagaaaca gaagacagca 3383641 tcggcgttaa gtatgcagag cttgatacat tgctggagca atctgatttt attcttctca 3383701 ttacgccgct gactgatgaa acctatcaca tgataggaga acgcgaattt aagttgatga 3383761 agaattcagc aattttcgtc aatatttccc ggggaaagac agttgatgaa aaagcactga 3383821 ttcgcgctct tcaggaaggc tggatcaggg gagccggctt agatgtatac gaaaaagagc 3383881 ctgtcaccca agataatccg ctcctgcagc tggataatgt cacgctgctt cctcatatcg 3383941 gttcagcaac agctaaagtg cgcttcaaca tgtgcaaaca ggccgccgaa aatatgctcg 3384001 cagcgatcca agggcaaaca ccgaaaaatc ttacaagaga atttcaataa atcaaaaatc 3384061 cggtctgata acagaccgga tttcatatta catacgctga agaacagcac gcttataaat 3384121 atgacgggtg acgatataat aaagagcctg gaatacaaaa taaatgaaga tgacaattac 3384181 ggcctcaaga aataaattgg aattcagcat attacttaac gctgcatacg caaagcccgc 3384241 gtgaatcgta cctgcgataa atgggatgaa gaataaaaat cctatttgct ttccaaggat 3384301 cgagtgaatc tctttgtccg taacccctat cctctttaac gctaacacct gcactcccgt 3384361 atcttctatt tccgtaaaca tccgcaaata cagcatgctt ccttgcacga taaaaaacag 3384421 cacgctgaca aacagaccaa taaacagcat taatgcaact ccctgcttca caatttgata 3384481 actaggagca cgtgtttgaa aatcagatgt atgttctttc ggcaccatgt tttcaagctt 3384541 ttcagagaca tccaccgtct cctgccaatg ctcaagctca taacctacca ttctcatctg 3384601 ttccttcagc ggcacatcct gtgacagact gtcaaagctc ttttcgctga caaccaataa 3384661 acggctgact ccatcgacag acatcaatat ccctttgttt tgctgctttt tcatgacata 3384721 ggaaagggtt tttcctgact tcatatgaaa tgctgctgtt tccccttctc caaatgtgtc 3384781 tttcaccatc atttgaaaag aaacattaat aaatgcttca ttttcttgta aatgaataac 3384841 tgggaaccct ttttcctttg cgacttgatt atagactttt tctgaaatca gcaaagcttc 3384901 agcttccatc ttcttatttc catacggcaa gtctgactga aaagtgacag gaatccctgt 3384961 ggcatccacc ttatacgtga taacagcatg agcttttttc aatgtattct cagccgtctc 3385021 aggcttcatg acctgaaagc gggaagcatc cttttccacc caggaaacag actgaggaat 3385081 gctttgctcc tcctgccttt gtaaatcgga ataaaacata tagatgacac ctgtagctgt 3385141 tagtatgacc gctgtaatga cagaggttaa aaacagcatg cgtgcatgat ccttcagcct 3385201 gaatatcatg ttggaacgca caatgatatt tgtgcctttg tagaagctgt gtttctttcg 3385261 gtacagcatg cggaaaaatg ccacactgct ttgggtaaaa aagaaatacg tgccaattaa 3385321 cactaaaatc aaaattggaa aaacccgaaa catcatgtca attgcattgg ctgttgcaga 3385381 tagataataa ccgctgccaa gacatagcaa agacaataca gtgagccatt tcgaataaac 3385441 tggcaaactt ttcggctttt tggctgattt aatcagttca atgatttcca gcttccgaat 3385501 ccgtcccagt gataaaatga gcagcgtctg aaacaggatg agaaagccgg caattgtcat 3385561 cacaaacgct ttcggcacaa tggcaaacga aatcggcacc ttcacgctga gcatccatgt 3385621 catgatcata aaaaacagtt ttgaaaataa caggcctgct ccaatgccgg ccgcaatcgc 3385681 cgcaagagaa ataagtgact gctcataata aatcatcttg cgaagctgct gctttgatgt 3385741 gccaaacagt gtcagcagcc caaactcttt ctttcttgcc tgcaaaaacg ctgaattgga 3385801 atatgtgatg aaaaatatac aaaacacaat gatgacgaca agagctgcgc tcaagcatgt 3385861 tttgacaagg cttcctccat atatattgtc ttcattgaca tcaggatgaa aaataaatga 3385921 tgtgaagaca aaaaacaccg aaacggcaaa cacacagctt aaaaagtagg ccacataccg 3385981 ttgcagattc ccaagaatgt ttttacgggc gatagttctc aaattcatga aaatcgcctc 3386041 ccaacacact caaggtatcc aatatacttt gataaaacac ctgcctgttt gttcctctgt 3386101 gaatctctga aaagaaacgt ccgtctttaa taaaaacaat ccgtttacag aaacttgctg 3386161 ctgtggcatc atgcgtaacc aacaaaatcg tcgcttcctt ttcctcattc agctgagcca 3386221 gtgtgttcat cacttgcttt gccgattttg agtcgaggtt tcctgtcggt tcatcggcaa 3386281 gaatgagcgc cggattgtga ataatcgctc tggcacaagc tgcccgctgc tgctgtccgc 3386341 ccgacacctc atatgtgcgg tgatcgagaa tatgctttat ttgcagcgta tccgccagtt 3386401 catccaatcg agcttccatt tctctcagct ttaccttatc caatgcgagc ggcaagagaa 3386461 tattttcacg aatcgtcagc gtatcaagca gattaaaatc ctgaaagacg aagccgagtt 3386521 ctcttctgcg aaacaaagcc agctcttggt cctttaacgt tttcggctga atgccgttga 3386581 tcatcatctc gccctgggtc ggcttatcaa tggtagccag caaattcaaa agcgtggttt 3386641 ttccgcttcc cgacggcccc ataatcccga caaattctcc ttttgacaca ctgagatcaa 3386701 aggcgctgag cgcttggtat gatattgttc ctttatttga atagtatgtt ttcgataggt 3386761 tcgttgtttg caacacgttc atgttctgct cctccttttt ctttattata aaaaggaagt 3386821 cagcatcctc ccatcgaact ttcttgcaat tccgctcccc aatcttacaa tgctgtcaca 3386881 ttcacgaggg tgtcacttga aaacacgatg gtcatcacag tgccagcccc ttcttttgat 3386941 tccgcataca gcttatggcc gagacggctg cacacctgtt ttgctaaata aaggcccatt 3387001 ccagttgcct ctttcatggt tcgtccgttt tctccggtaa aaaacgcgtc aaaaatccgc 3387061 ggcagatcct gcggcggtat gccgattcct tcgtcggcaa ccgacaagcg cgtctcatgt 3387121 ccctgtgttt caatccggat tgtaataggg tctcccacac cttgctttga atattttaag 3387181 gcgttgaaaa ggatttgctc aacaacaaag gaaagccact tttgatcact ggaaatctga 3387241 acggcatttg gcggcacatg taatgttgga aaaaggcgcc gcttgataaa ctgacgtttt 3387301 tcctgattga tcagtgaacg aaccatttct gccaaatcaa aggtttgcgg ctttacatca 3387361 aatgcaaatt cctccagccg ggccgtttgc agcatcatat caagaccgtg gcgaaatctc 3387421 tcattctcat cctccagctc ctctaaaaac gtcggaaaag aggatgaggt tccgtttttt 3387481 ccttcctgaa tcattaagga tatgacagat accggtgttt tcatatggtg gacccattgg 3387541 ttggtgaagg tgtaatgctg tttttgctga ttgatatatt gtgagagcct gctttcgtat 3387601 tgctgcccga gtgcgttgat catcttcgtc caaagcgctt gctctcctgt tcttggcttt 3387661 ctggctttca aagactgtcc gatgtcattc gaagaagagg cttgttctgc aagcttttta 3387721 acatatgtga gaaaggaaaa ttgccgaaca taatcagcag caaaacctgc ggctaaaaga 3387781 gtaccgggca aaatccatat gtacatcata ttttctttgg aaggttctgc gccgctctct 3387841 acaatgctta aatacgcaat cagcatggcg gaccctatcc ctaataatga aaatagaata 3387901 atggctaagc ggtcgatgag ataagtcttt aacattccgc ttcatccttc cgattgactt 3387961 gaaattgata accttgtcct ctgattgtgg aaatgcaatc tgtcagtcct gcattctcca 3388021 gttttctccg cagccgattg acattgaccg ttaacgtatt gtcatcgaca aaatcaacgt 3388081 catcccataa cgcctccaat agttcatcac gagagacaat ttttttatgc tccctcacaa 3388141 aaatcgagag aagctggaat tctttttggg aaaacaaaat ccggacgctg ttccattcgg 3388201 cctcattctg atcaggataa atcgtcagcc cgccaagctc cactattcta gattcctgcg 3388261 gcaaagaggg cgaatattca ccatatgtgc ggcgcaggac gcttttgatt ttggccatca 3388321 ctacctctag atggaacggc tttgtgatat aatcatcgcc gccattttca atcgccatta 3388381 cctgattcag ctcatcggtc cgtgccgata taaagataat cggcgcattg gaaatggtac 3388441 ggatttgcct gcaccaataa aacccgtcaa aaaaaggcag gttgatatca agcagcacaa 3388501 gatcaggctt catttctgca aattccaatt ttatatcatt cagctgttca gcaattttca 3388561 cttcatatcc gtatttttga agatgaccgc ccagcaaaga agcaatccgc tcatcatctt 3388621 ccacaagcaa aatccgatac acgttgatcc cccttatatg tacatcacga tgatttttct 3388681 agaagattcc aaaattatta tagcatgtgc ggaatagtaa atcggtcttt ttctttttgt 3388741 tatgatagaa tgataaaggt aaaattttca taataggcag gtgtcgtgat gaagaaaatc 3388801 atgctgtttc tggcaatgac gtcaattctt tcagcatgtc agcccaacta taccgggaaa 3388861 tacatagaaa ttggggatac actaactgac tataccaaag agtgctttaa agagaatgaa 3388921 attccttata aatacgaaaa gggaaaactg tatatcccag aagacgcatt tgatacagca 3388981 atctacactt gttcataaga aaaagcttgc agataacctg caagcttttc acgttacaaa 3389041 aaatgagtat ttaatttctc ttcaaatcct gaagggccga tgtcgctttt ttgaatgtta 3389101 ccgccgtttt cataaatcgt aaaatggcgc tctgacatga ccatccttcc gctcggcgtc 3389161 agctttgagg caagcaggga tttgttaaaa ggagattttt catgagagtg aatgatgtcc 3389221 ttcatgttat ctaaatcacc gagatcactc tcttcaaggg taaaggcgta cccaatttgc 3389281 cagccttctc ctttgtccat cagcagaaca tagctgccct tttctgtctc ttcctttttg 3389341 attcggaatg acccgactgg tgactgtacc gtttctccgg aaagcggtat cggctggagc 3389401 gccaggttga tgccgaagcc gatatcaacg aggtaatcgc cgttttccgc agacagccat 3389461 acagcagcat gcgtcccttc tagtgcccat ccctcttgat cgcctgcata aaccgttcct 3389521 cgaatgagct tcacatgaaa cccggcctca cgcaagacaa aataaaggaa accatttaga 3389581 tcgtagcata ggccgccgtg ctgatctttg agcagacgtc gccatagctc ttcttttgtg 3389641 atcttataat tctcttttgc aagtacggca cggttttcga atggaaaacg gtatgccatt 3389701 gctttaagaa aaaggggaag atcgccgaag ctgacatggt ctttctccca gccgattttc 3389761 tgaaagcagt cttttagaaa gtcactcatt tttatcacct aaacttcttc ttgaacgtaa 3389821 gcagccagct tctccagcgc ctcttgttca tcttctccct gggcaatcaa ggtaacctca 3389881 gtgcctgtgc ttaccgcaag gctcatcagc cccatgatgc ttttggcgtt tacttttttc 3389941 ccatccttct caagaaacac atctgacgta aaccggtttg cttcttgtac aaacaaagca 3390001 gcaggacgtg cttgcagtcc tgtctttaat cgaacttcca ctttctgttg aaccataaga 3390061 tctccccttt tctttacggt tattttaaag tgacggtttg ccctgtccgc agctgttctg 3390121 cgatttcgtc aagttttctc agcctgtgat tgatccctga tttgctgatt ttcccgcttg 3390181 ctaccatttc ccctagctct ttcagcgtca cttcctgata atcaatccgc agctgcgcaa 3390241 tttcccgaag tttttcaggc agcgcctcca ggccgattct ttcatcgatg tatttaatat 3390301 tttccacctg tctcagcgat gcgccgatcg ttttgtttaa gttggctgtt tcacaattga 3390361 cgaggcggtt gaccgaattt ctcatgtccc gaacgattct gacatcctca aatcgcagaa 3390421 gcgaattgtg agcgccaatt acgttcagaa actctgtaat cttttcagcc tcttttaaat 3390481 aggtaatata gccttttttc cgttcaagcg ttttgctgtt taactgaaac tcatttaaca 3390541 ggtcacataa tgaatcgtta tgctccttat aaagagagaa gatttctaaa tgatacgagg 3390601 aggtttccgg gttattgacc gaacctcctg ccaaaaatgc tcctctcata taagaacgct 3390661 tgcagcatct ctttttgacc agctctttcg aaatacttcg ttcaaacaca aaattctccc 3390721 cgagtatttt taaatcctct aagatcgctt ttgcattttc tgaaaaacgc acaatataga 3390781 cgttattctt tttcagccgc attttctttc tgaccagcag ctcgaccgac acatcatatt 3390841 gttttttcag caatgtatag atgcggcggg caatcgccgc gttttcggtt tgaacatcga 3390901 gtacgagatg gcggtttgta aatgataaag ctccattcat ccgaatgagt gcagacagct 3390961 cggcattaat gcagcagtcc ttcacttcca gattcgttaa ttcttttttt gtttctgatg 3391021 caaatgacat atagccacct catttcaagg cttcattctt tcagtaaatc aacaagaaga 3391081 gaggccactt tatgtgtatc gtgacgtatt acgtcatttt tatacgttac aatttgatct 3391141 ctgatgactt caagccccat cgctttcagc tcttcgatat caaaatcaac aggacgcgcc 3391201 gattccattt cgtacttacg ttttatttcg tcgggaatgt cttcactgtt cactaatatc 3391261 gtatcaataa aaccacagcc catatgctga ttgagcgctt tcacatgatc agcagcggtg 3391321 taatggagcg tttcgccggg ctgagtcatc acgttgcaaa tgtatacttt tttcgccggc 3391381 gcctttatca cttcttcccc gatttttggg acgagcaaat tgggaagaat gctggtatag 3391441 aggcttcccg ggccgataat aatcaaatcc gcttccctga ttacgtctat tgtttccggc 3391501 agcggatcaa tctgttcagg cgtgagaaaa acacgcttaa tgcgctgtcc gtattctggg 3391561 atcgttgact cgcctgagac cacgcggcca tcttccatct cagcatgcaa aacgacactg 3391621 gcattggcag ccggcaaaac ctttcctctt acattcagca ccttgctcat ttctgtgaca 3391681 gcgtgaaaaa aatcaccggt tatatttgtc atcgctgcca aaatcaaatt cccgagagaa 3391741 tggcctgtta agtcattccc tttattgaag cggtgctgaa aaagatcttc aacaagcggc 3391801 tccacatcgg ataaagcggc aagcacattt ctgatgtctc cgggaggcgg aattttcagt 3391861 tcattccgca gacggccaga gctcccccca tcatcggcaa ctgttacaat ggccgtgatg 3391921 tcaacgggtt tatgctttag gccccgaagc aatacagaaa gacctgtacc gccgccaaag 3391981 attgcgattt tcggcttttg tcccatctta tttccggctt ctcttttcaa tgtcccggtg 3392041 agtaacatga gtatagtaat cctttttgaa ataatcagct aaattctcgg ctaatgtcac 3392101 agagcggtgc tggccccctg tgcagccgat cgcaatgaca acctggcttt ttccttctct 3392161 tttgtaagat ggaagcataa agctcagcag atcaattaat ttctcattga acttttgcgt 3392221 ttcattccac ttcatgacgt aagaggaaac ctctttatcc ttgccagtca gcggccgcat 3392281 gctttcgata tagtacggat tcggcaaaaa tctgacatca aagacgagat ctgcatcaat 3392341 tggaataccg tatttaaaac caaatgacat cacatttacg gtaaatgtct ctccttggtt 3392401 tgtcgcaaag tgcttcacga ttttttcacg caaatcacgc ggcttcatgt cagacgtatc 3392461 gtaaatgatt tgagagcggc cttttaattc ctcaagcagc tctcgttcta gcgcgatgcc 3392521 ttcaagcggc aggccagtcg ctgccagcgg atgcgagcgt ctcgtttctt tatatcttgt 3392581 gacgagaatg gaatccttcg cgtccaggaa taaaattcgc ggtgtgatcc acggattttc 3392641 ggccatttca tccagcgctt caatcagccg gtcaaaaaat tcgcggccgc gcaaatccat 3392701 cacgagcgca actttgctca ttttcgaatt tgattccttc atcagctcta aaaacttcgg 3392761 aagcaatgaa ggcggaagat tatcgacgca gaaatagccg agatcttcaa agctttggat 3392821 cgcgacagtt ttccccgctc ccgacattcc agttataatg acaagctgaa tatcatgtga 3392881 ttcactaaca ctcatctttc tcccccctga cttgtctttc tatttgatgt gctgcgggtc 3392941 taaacgataa ctgagcagct caaattccgg tgtatacgta aatgtgccgt gcagcagccc 3393001 ttgtcccttc atcataaaat caaggatatg gccgtctcca ggggccatag gcaggttctg 3393061 aatgtcattg acatcgtgcc actgcagttt gccttcctct gattctgata cattttgtcc 3393121 tgtatatgaa tcagcgacaa acgtaaacat catccactcg gagacaatgt ggtcaccgtc 3393181 tttaataata aaggtaaaaa cgccttttaa ttgaggattt atgatataga taccagtctc 3393241 ttctctgtac tctctgatga cggagtctct gactgattct ccgctctcca tcttgcctcc 3393301 cggcgcgacc caccatccgc gtctcggctt ttgaagcaga agaactttgt catccgtctg 3393361 aagcacacaa tttgtcactc tttgcaagta cgtcacctaa ccttcgtcct gtcatcgtct 3393421 ctttattata ccgcttcaag atgcctccca caatgaagag acattgacaa tcttttcttc 3393481 tattttacag catattcatt ccttaattca gatgattttg ctgtaactgg aattctcttt 3393541 tatttatgga caaaaaaagg acacggataa ctggagaatc cgtgccaaaa aagtgtattc 3393601 attataaaaa gggggtcaat tactttatta atcataaccg aaaagcatta cacatgtgtt 3393661 acagcggaat taaaacccag taacgtaatg tgaaactcgt atgacagccc tttttatttt 3393721 aaggttttca gcgtttcttg gagctcttcg acataatgtt gtacgctttg tgccgcaatg 3393781 cttccgtctc ctgtagccgt tacgatttgg cgcagtgatt tttcgcggat gtctccggca 3393841 gcgaaaatcc cttcaacctt agtttccatg cggtcgtttg tttcgatata gccttcttca 3393901 ttcgtaatgc ccaggttttc aaacggttta gacagaggaa gcatgccgat gtaaatgaat 3393961 acgccgtctg ttttgaattc actttcttca ccggttaccg tatcgacaag cgttacgtta 3394021 ccgactttgc cgttttcctc atgaatttcc ttcacagttt tgttccatag gaagtcaact 3394081 ttttcattat caaatgctct cgcttgaaga atactttgag cacggagttt atcacgtctg 3394141 tgaacaatcg ttacttttga agcgaaacga gtcagatata cgccttcttc aaccgcggaa 3394201 tctccgccgc caacaacgac aagttctttg cctttaaaga aagcgccgtc acatactgca 3394261 caataagata caccgcgtcc gcccaattct ttttcgccag gcacgccgat ttttttatat 3394321 tccgcacctg cagcaatgat gacagcacgg gctttatatt cctttgaacc agctttgact 3394381 actttgtact ctttgccgtc aatgacctct ttaatatcgc cataagcgta ttcagcgccg 3394441 aattttttcg cgtgttcaaa cattttgtta gaaagctcag gcccaaggat actttcgaat 3394501 ccaggatagt tttctacatc ttccgtattg gccatttgtc cgccaggaat tcctctttca 3394561 atcattaatg tcgataaatt cgctcttgat gtgtatacag cggccgtcat cccagcaggg 3394621 cccgcgccga ttataatcac gtcataaatt ttttcttctg acacactatt cactccttaa 3394681 accatctttt caagtttggg ctctttctta taagataaga atccccatca aacgtattcc 3394741 ttacccatat cctataaaat ctcatggtga tacgctattt ttttgctcaa cacgattaaa 3394801 tgtattcgaa aagggtatat gttaataaag aaagagcctt ctgtttatag aaggcccttg 3394861 tcatatttat tattgaacaa cacgtcttac aacaccttta aatgctgctt tccagtaagg 3394921 attgctcata gagtcaacag atacgccatg agatgtattg tcgtttagga aagtaccgtt 3394981 tcctaagtag attcctacgt gtccatttgt tttgtaagtg tcaaagaaca caaggtctcc 3395041 gcgtttcatt tcagacgcgc tgacagcttg tcctctgcca actaacgtat cagttgttgt 3395101 tccgcctaca ggtccaaggt taacacctgc agaagcgtat gcccagcgta cgaatgatga 3395161 gcagtcaaaa atacggttgt tgatatcaga ctgagtgcgt ccgccgccaa acttgtacgg 3395221 agattgtcct acaatgcttg aaccaacgct gatcgcgcct tcaattccgc cagagttgct 3395281 gataacagtg ccgcctgaat tgctgtttga gccgctgctc ttcttagaag atgagccgtt 3395341 tgacgaactg tttgatgaac cgttagaaga attgtctgaa gaattgtctg aagaatcatc 3395401 agatgagctt gcttttgatg attcagttgt cgccgtttga ctgtcatctg tttgtgtttc 3395461 atcagatgct ttttgtgctt cttcctgctt tttgatcaaa gcagccgctg cttcttgttc 3395521 ttttttgatg cgtgcttgtt cagcttcagt atttgctttt tgatttgcaa gttcagacgc 3395581 ctctgatttt aattcagaaa tcgctttagc cgttttcttt tggcttgctt ttgcttcgtc 3395641 gaaaagcttg tctttttcat taagctgttt atcaaggtct ttttgcattg tttctaattt 3395701 agccaaggca gcttgaactt ctttcagctt gtcattcaaa tccgcttcag aatcttcgag 3395761 cttcgcttta tcctgctctt gctgtttgat taaatctttg tctgcgtcca caatagatga 3395821 aaccgcagtc gcacgagaga taaagtcacc aaagcttgtt gatcctaaaa gaacatctat 3395881 gtatccttga gatccgccgc tttcctgtaa agaacgaacg cgttttttca ggatttcatt 3395941 gcgtttttcg atgcgtgctt cagtttcttt aatctctttt ttcagttttt tgatttcttc 3396001 ttttgtttta tcgttttctt cttttttatc ttcaatcttg ttgcttgtat caagcgcctt 3396061 atcgttaatg tctttcagtt ctttttcaat ctttgattga ttttcctgaa gctcggttaa 3396121 ttctttttcc ttcgcttcaa tgctggaagc aacctcagat tgcttgcttt cgattttttg 3396181 tttcttttca tctaatgttt ccgccgatgc agttttactt gtaaatggga tcaaaaaact 3396241 gcttgtcccg atgacggaag ccaaaccaag tgtaattaaa ctctttctca ctttttatat 3396301 cctccctttt actgtgaacc tgtcctcatt tggaatcgta ttttgaacat caagtttcgt 3396361 tcctcatact ctacgaggaa tgatggttgt ttatggttaa ttattctgtg catctcttat 3396421 tctggttgta tagcgtttat ttcacatcat atgtaaaaaa cactaattcc ttatgtacga 3396481 gaatcattat accatcaagt ttcgacaaat tagcgataaa ttttattaca tttatgtttc 3396541 aaacagatgt caagtcacac atcatttgtc atttttctta agcgtgtaaa aaaactgtcg 3396601 atattatttt cttaatataa tctatctaac aaaaaaagag tcgattaaat aaatcaactc 3396661 tttaaaattt actattctag aatatcatca atatatttca tatatttcgt caaagttgcc 3396721 ggagagatgc cgaatcgggc cgctgtgtct tttttcgtgt cttgcttgcc atgggcttct 3396781 ttccaaatat aacagatggc tgctgcccag cctttctcat tcttcaacgg agcagctgca 3396841 cgaatttgct ggatgacatg aaaaacccag cagctcatga cttctgtttt catctcttct 3396901 ttttcagctt gctctaatag tttgaccgtt tgataagcga aaagtgcatc ctctgaaacg 3396961 tcagcagccg cagaatctcc attcagaagc agctttacaa aatgagtttc aaaaggagcg 3397021 gtaattctct ttgagcgtat caccgcttca agatgctctg tttctccctt tgtgctgctg 3397081 atataatagg ctgcgagtcg ctgctccaca gatgaaggaa gagcttccct ccgctcaatc 3397141 caaggcgccg ggcggtcttc gccgggatat tgcgactcga cttttctcca gatcgtctcg 3397201 gcaaagtcgg tatgtcccgt aaaataagca gagcaggaaa gccagtaaaa gaaggtgtcg 3397261 tcaccctcaa agccggtttt atataatgat ttgagccatt tatatccgat ctcgtagcgg 3397321 ccgacaagcg ccaaagtagc acccaattta taacgctgct ccaatagcat cggatagaca 3397381 ttggagagct gatcactcaa ttccgccact ttttcgtctt ctctttcata atagtagaaa 3397441 acgagaagat tgcataaggc gtgaagattt ccttcattat gagaaagcac ttcataagcg 3397501 gtttgcttcg cttttacaac gtttcctgaa tagaaatagg caagcgcgag attgttgtat 3397561 gctgaccaaa gctccggata ttcagttgtg atttcctcaa gcgccgcaac cgcttcagca 3397621 agctggccgc tttccagcaa tgactttgcc cgatcctgtt tcaccagcag ttcatcctga 3397681 tcatacaacg aatcctcaat gccgtcgtct cctaaatcga gcaaatcaag cagactatcg 3397741 ttttcttcgg cgaattcacc atccgggtcc gcatcagaat aagcggccgc ttctttataa 3397801 gcttcctgga agagccccag atgggcaaag ttattcgctt taaagtaatg gcactccggc 3397861 atttcggcct ccagatttgc catgatatag tcaagaagat cgttcgactc ttgatactgg 3397921 cccatttccg aataaatgac cgcaagctgt gaaagcatct ctgaatcctc cggctccaaa 3397981 tgaaccgcgc gctgaatcag tttgcttgcc cgttttagat tgcgctcttt atacgctttc 3398041 aagcctttat gaaaaaaata ttgtccatct tgaagcagct ggacaatttg tgcgtgattt 3398101 ttatgttcag aagtgtgttt tcccacaact accctccgtt ttatacaata ttaccgtcag 3398161 tagtatacca taaatcgtaa gcccctcaat agttcaaaag gaaggattgg gaaaatccct 3398221 cctctttttt attggctgat tcgaccaaaa tttacccggc tttgttttct aagtccgcat 3398281 tcattttcag ctgctgttca gcaaaatccc ggtaaaggcc atgggaagcc attaactcat 3398341 ggtgtgttcc acgaccggta atttcccctt tttcaacaaa caaaagctgg tccgcatcta 3398401 caacggtaga taggcggtga gcgataacaa tcgttgtgcg gccctccatc agcacctcca 3398461 gcgcctgctg aactgatttt tcagattggc tgtcgagact tgaggtagct tcatcgagca 3398521 taagaatgct tgggttacgg agaagcgctc tcgcaatcgc gattctttgc ctttgtccgc 3398581 ctgacagcat aatgccgcgt tcgcccactt ctgtatcaaa ctgattcggc agctccttta 3398641 taaaattgag cgcatatgcc atctccgcgg ctttttcgat ctcagcatcc gtcacatctc 3398701 gttctaaccc gtagcaaata ttttctctga ttgtcccgga cattaacggg ctttcctgtg 3398761 atacataccc gatatgctcc ctccacgatt caagcgagta agtatcgacc ggctcgtccc 3398821 ccagccgaat ggtccctgca gtcggagaat aaaagcgttc aagcagctta aacagcgtcg 3398881 tttttccccc gccgctcgga ccgacgatcg ctgtcacttt ccctgcttca atgacggcgc 3398941 tgacctcttt taagatcagc tgatcaggct tatatccaaa agacacgcga tcaagctgga 3399001 taggcagatg tgcattttca atttgttttc ctgtcactgt atcttcctct tcctctgcca 3399061 aaatctcaat cattcgttct gttgcaccga ttgatttttg cagctgtgtg aaaaacgttg 3399121 taatctggcc catcggcata ataatttgaa acaaatataa aataaaagcc acgagcgctc 3399181 cggctgtgag ctcgcctgat gagacctgca tgccgccata tccgatcact gcgacaagcg 3399241 ctgccattaa cacgagtgaa ataagcgggc cgacaagcga ttgaaccttg gcttcacgaa 3399301 cgccaagctt aaataatgag gaaatcccca tcttcccgcg cccatattcg acatcctccg 3399361 catttgaagc cttaacaagt ctgatttccg ggagaatttg attaagcagg cctgtaaaac 3399421 gagccgtttc atcttgcgtt tcccgtgaaa tggagaacat tttccgtcca atcggcacca 3399481 aaataagagc ggccagcgga acgaccacta acacaagcag tgtcagcttc cagttcataa 3399541 taaacaagat tgtcaatgat ccaatgacag aaatgatgcc tgtaataaat ccgctgatat 3399601 gggttgtaat caattctttg accaccatcg tatcgttcgt tacacggctg actgtttctc 3399661 cggaagcatt tgtatcgaaa taagagacag gcagcttaat taatttcttc cataataact 3399721 cccgcagccc ggaaatgatt ttttgtccat tatagttaag cgcataggtg gcataagcgc 3399781 ttaaacccgc ctgaacgaaa aacaccagcg cgatcaaacc gatttgcgtg cctgacagat 3399841 ttgacataga aaaaccatcg acaagctgct tcgttaataa tggaatgagc aggctgacca 3399901 gcgtggttac tacactgagg gcaagcgcaa aggcgagctt tccataagaa ggattggtcc 3399961 gtcttactaa ggcaaaaaag ggtttcaatt tacttttaga tttttgtttc ttggttggca 3400021 tatattttcc tcctgtttca gcgttcagaa aggtgaaaag tcatagcaaa aggatgattt 3400081 ttactctttc tcaatcatat caatggagaa agactttttc agtatatttt tgccgtgatc 3400141 aaaataaaaa tctcccactc attgtttgaa taggagattt ttgtgttaga catctttcac 3400201 tggcttcttt tttctgtaag tcaatgttac atcctgctgt cgcaggtctt ctattatcat 3400261 tttgtaccga tcaacttttg cggtatgttc ttcttttatc atctgaaggg cagcttttcg 3400321 tttttcgcta ttagactcaa gctctttttt tatttttttt acaatcaacc ctttttgccc 3400381 tttgatttcc tcttttaatg aagactcaaa tttctttgtc aggctgagaa agtcgttgat 3400441 cggttgattg agggtgcccg ctttcccctt catttcatct tgggtaagaa acatataggt 3400501 cgttgataca atttctgttt cactttctga aaataaggaa gtcactcttc atattcctcc 3400561 taagactgaa aatcaaataa ctgagaaatc atttcttctt tttcaaacag cttttcaata 3400621 ctctcgcgga tatttttgat aaaatctctt ttttctgttg tctgtttttt taattcagca 3400681 acaattccat catttgcagg aagcgcacct gtgtggaatg attcatgaac tgagattttc 3400741 tccaatttat cgaatgtgtg gctgaaacca gctgcaagcc ggaattgaag atcgaaggca 3400801 taatgcgaag ggttttcttc catatgatga atagccgtga tgatcgcctg ctttttgtct 3400861 atgaagtctt catcgatttc ctgactgtaa accttctggt acttagaaat cgcatcttcc 3400921 atatcttcaa cgattttcat accgttttga tagattctga cagcggatga gagattgact 3400981 tgaatcgttt ctcccgagcc actcttccct gtaaaataaa tatcggagcc tttatagctg 3401041 aagccttttt cctttgacaa ggcgttgagc atttgaacga tgctgtggcc gtcgacgata 3401101 agttttagtg cgtcttttgt ttctgtgtcg agtgttttca atgaggacag aattgatttt 3401161 acatagtcca ctatttcacc aacgtctttt aaagcttgca taaattggcc atgttttaga 3401221 tggtctatga aatgttcgta ccgtgactct atgcctcgca tactcgcatt aatattcgtt 3401281 aattcttttt tgatgacttt cttttgcgtt tcatcaatat aaccattttc agctaactga 3401341 tctacgaccg gtccgctgtt tctcaacaag gtatgaagaa aacctaaaaa cgacggcagt 3401401 tcctctttta ttcggccata catttgctta acatcatcaa aatgctcata taggacactt 3401461 actttcttta aagcgccgtc tgtgtttttc actttttcaa tcaggtctat gtctatcccg 3401521 ctggctgcct ttataaaacc gttcaagccg tctttttcat agtcatcctt atatttttga 3401581 aggaattttt gaattgacct cacatcttcg tcaggaaccc catccataat gtttcggatg 3401641 ccttttacac ttgtatttgt atctgccatc ttcacatcac cgaatgtaat aaaatcggcc 3401701 ttgccgctga ctccatacag cgggtcatct tttgagatgc gctgagtgat gtttgttgtt 3401761 acgcctttgt cttcataata tttttggatt tcttttttta acttttctgg cgggatggaa 3401821 tctatatctt catatttata actaaatttc ctaataacat atctatataa actttcatca 3401881 gtttcaagta attgatcaat attgacttga gctccattta ccccataaac ttcatcatat 3401941 tctccatcaa tcaattgcac cataacttgg ttattatttg caagtgaatg tcctaaggcg 3402001 aatgttttta aatcctcaga gttacctgct gctttctttg ctttgttagt aaactccttt 3402061 gtagcctcat actgactatg atcaattcct aaaaaaagac caaaaaagtt atatgaccaa 3402121 tccttattat cggcactacc ttctgaaata atctgaagct gatcaatatg ttttttctca 3402181 tctattatat ggattgccgt tccatcgtaa cctgattctc tggtcgaact ttgtatactt 3402241 gtattctgat ttacaagttc attggaggtg taaatttcaa ttttcatatt ctcaggaaga 3402301 tcgtggtggg tttcctcttt ataaattctg cgtatatctg cttcgaaatc cttcttagct 3402361 ttcttaactt cactcgcaat agttgaggca aacttttgtt tatagtcata ttctaaatca 3402421 attaacctta actttacgtt ctcattctca aatacatttt tatttcccat cttatttctc 3402481 ctttttatct attaaaaagg tgatagaatt aattaatttc tcaactttat ttttagcctt 3402541 ttcttcatct aaggagcatg gttgattttc atttttgcat ccaagggtaa aggcgtattc 3402601 tactcctagg ttatcttcct ctgtagactt aacatatcca aaataactgt atgaataatt 3402661 atattttcta tcaatatcgt caaagatgtc ttttttcttg gcagtgtaaa tatccgtttt 3402721 ctttttgctg ctttttttgt attcgccttt ataatcattt tttccactaa caatatctag 3402781 cattgtctta ggttcattcg caaaactttc ttctttgtaa tatgttacat ggccatcaaa 3402841 cattacattg gtgtctttat cataactatt aaatccaata ctttctttgt ttttcccggt 3402901 taacgatgat cttcttgata gatactttcc atcctccgga aacaacatcc taaacccttt 3402961 cagcttagat tccagcaaat aatatcctgg ttcctcttct tttgttgaca ccatgtactc 3403021 tctcgttttc tcgtcctgaa acgcaggtac ttgaggcaga tccttgggat ccatgtcttt 3403081 tggttttacc gcttctgttt tattgtcatt tgtgctgttt ttatcattgt cattcatact 3403141 gcatcctcct gtcagggcaa gtaataagct gaagcaaata aagatgatct ttttcattac 3403201 gaacctccac gggttttgtg agaatagtat tctattttta tatcaaaaat aattctattg 3403261 acctggttaa gagatgatta tttcatcctt tttcatgtta catcatggcg gaatttggat 3403321 aaataggaaa tgagactcgg ttttgatctc cttttattaa ctaatcatat ataacaccca 3403381 atataaatct aaatacctat tacttttttc acaaaacaaa aagagccgta tcatccggct 3403441 ctttactctt caatctcaga atggcgtttt ttcaatacgt caagcacatc atccagcggc 3403501 agggattgtt ctctgagcag gacaagcagg tgatacagca ggtctgccgc ttcccatttg 3403561 agttcctcat gatcccggtt tttcgcggcg atgatgactt cggatgcttc ttctccgact 3403621 tttttcaaaa tcttatcgac gccttcacgg aagaggtacg tggtgtaagc tccttcaggc 3403681 atttccgctt ggcgttccgc gatcacccgc tccagttcgt tcatgatgcc gaatcggtcc 3403741 gcggcctgtt cttctgtttg ttcctttgta aaacagctgt agctgccagt gtggcatgcc 3403801 gggcctgacg gttctacgag tacgagcagc gcgtcttgat cgcagtcata ccggatacct 3403861 ttgacggctt gcgtgttccc tgaggtttct cctttatgcc ataacgcttg gcgtgagcgg 3403921 ctgtaaaacc atgtttcctt cgtttccagc gttttttcgt acgattcctt gttcatatac 3403981 gcaagtgtca gcacttcttt gcttgccgca tcctgcacga tagcaggaat taatccgtcc 3404041 tcgttaaaac gcagttcatc tgcctgtttc atctcacatt caccccgtac tctttcaagt 3404101 atgatttcac ttctttaatc gatgtttctt tataatgaaa aattgaggcg gccagcgcgg 3404161 cgtcggcttc tccttttgta aaagcctcaa gcatatgctg tgcgtttccc gcgcctcccg 3404221 aagcgataac agggacgggg acagcttcgg aaacaagctt tgtcagcgtg tggtcgaaac 3404281 cttttttctc accgtcggag tccatgcttg tcagcaatat ttctcctgcc ccgcgtttga 3404341 cgccttcttt tgcccacgcg gtgacctccc aatctgtttt ctttctgccg ccgtgcgtgt 3404401 agaccttata tgtgtcagat tctttgtcat acttggcatc aatggcaagt acgatgcatt 3404461 gagaaccgaa aaactcggct ccttctgtaa tcagctcagg gcggagaaca gctgccgtgt 3404521 tcaccgacac tttgtccgct ccggcacgca gtatcgtttt catatcgctg agctgattga 3404581 tgccgccgcc gactgtaaac ggaatggcaa gcttcgcggc aacctgctcc acaacgtcaa 3404641 ccatcgtctt tcgtccttcg tgcgaggcgg agatatcaag aaaaacaagt tcatccgcac 3404701 cttcccggtc gtacacttcg gcgagttcaa ctgggtcacc ggcatccttc aattcgagaa 3404761 attgaattcc tttgacaacg cgtccttctt tgacatcaag gcatgggata atccgttttg 3404821 tgatcatttg cgcttcaccc tttcaagcgc ctcactcagc gtaaactgat tggtatacag 3404881 cgcttttccg atgatcgctc cagagacgcc gtccgcctca ttgcgggcga gagcttcgag 3404941 atccgcgacg gagctgactc cgccggaagc gatcaccgat ttccccgttt ccttagcaag 3405001 ctcgaccgtg cttttaacat tggggcctga cagcattcca tctgtcgcga tgtcagtaaa 3405061 aataaagact tccgcacctt cattggctag ctctttgccc agttcagttg ccttaagggt 3405121 tgatgtttca agccatccct ctgttgaaac aaaaccgttt ctcgcatcca gtccgattgc 3405181 aattttctcg ccatattgtt tcagcatttt tttgacaaac ggagggttag aaactgctga 3405241 gcttcccagg atcacccgct cgactcctgc tgataaatat tcatagacgt cattttcaga 3405301 acggatccca ccgccgattt cgactttcag gttcagcttt tgcgcaatct caatcacatg 3405361 gcggtcattc actcttttcc cttctttggc cccgtcgaga tcaacgagat ggatccattc 3405421 ggcaccctct ttctcaaata actcagccat gtcgtacggt gaatcgccat atatcgtttc 3405481 cttattataa tccccttgaa caaggcgaac acatttgccg tttctcatat caattgccgg 3405541 atataatgta aaagcactca ttttttcacc ttctgttctg ctgccatttt cgtaaattgg 3405601 gttaaaatag acattccgac cgtgctgctt ttttccggat gaaattgggc gccgaagacg 3405661 tttctttttc cgactacagc aggcactcgt acaccataat cggcgcttgc cagaagcgcg 3405721 ttctcctcca tcccgtcaat gtaataggaa tgaacgaagt aagcgtagcc ttgttctgtt 3405781 ttagtcagca gcggagattc attatgaaaa gaaagacgat tccagcccat atgcggaacc 3405841 ttcagcttgt ttcctttttc atcttctgct ttcagcctga ctgcttttcc ttttaacagc 3405901 ccgagtcctg aagcggtgcc gttttcttcg ctttcttcaa ataaaagctg catgccgagg 3405961 cagatcccga gaagcagcct tccctctgag accatatcgt gaatcaattg atcaagcttc 3406021 gtgtagccca aattgtccat cgcgtctcca aatgaaccga ctcccggcaa aatgaaagca 3406081 tcagcttctt tcagctcctc cggcttttca gaaacaaaat acggcacgcc gacacgttca 3406141 agcgcctttg agacactgta taaattcccc attccgtaat ctatcacgcc gatcatttac 3406201 agcatccctt tcgttgacgg tattccttta actcgcggat cgatcgttgt cgcttcatca 3406261 agcgcacgtc ccagtgcttt aaaaacggct tcaatcatgt ggtgggtatt tgttccataa 3406321 tgaacgatga cgtgcaggtt cattcgagct tcgagcgcca gcttccacaa aaattcatgt 3406381 acaagctccg tatcgaaagt tccgacttta gcagccggga aatcagcgcg catttctaag 3406441 tgcggccggt tgcttaaatc aatcacaact tgagcaagtg cctcatccat cggcacaaac 3406501 gccgatccgt agcgtttgat tcctttttta tcgcccaacg cttcgagcag cgcctgccct 3406561 aagcagatgc cgatatcttc agtcgtgtgg tgatcatcta tatcaacatc gccttttgcg 3406621 ttaatggaaa gatcaaattg gccgtgtttc gtgaataaat ccaacatatg tgtcataaac 3406681 ggcacatctg ttttaatatc cgcttgtcct ccgccgtcta ttgtaaatgc cagctcaata 3406741 tctgtttcgt ttgttttcct gacgcgttcc gcttttctca tttagaaatc ctccgttctc 3406801 tcgcttcaat tgatctggca tgggcttcta acccttccag tctggcaaaa gccgcgatgc 3406861 tttcggcatg ttcttcaaag gctgattgac tgtaagaaat aatgctcgat ttcttttgaa 3406921 aatcagttac gtttaatgga cttgaaaatc tggctgttcc gtttgtcgga agcacatggt 3406981 tcggtccggc aaaataatca ccgacaggct cagggctgta tctgcctaag aaaattgcac 3407041 ccgcatgttt gatactgcca agcaaagctt ccggagactg tgttatgatt tctaaatgct 3407101 ctggcgcgag tgtattgaca gtctcaatcg cttctaccat tgtttccgcc acatatatac 3407161 aaccgtaatc tctcactgaa gcttccgcta tttctcttcg cggcaaggtt tccagctgct 3407221 tattcacctc ggctgaaacc gtctcggcca gcgccatgga atctgtgaca aacacacatg 3407281 agctaagctt atcgtgttcc gcctgtgaca gcagatcggc tgcaatttcg ctcggaatcg 3407341 ctgtttcatc agccagcacg acgatttcac tcggtccggc aatcatatcg atatcgacat 3407401 cgccgaacac ttctcgtttg gcaagcgcga cataaatgtt gcccggaccc gtgattttat 3407461 ccaccggctc aatggtttct gttccgtatg ctaacgccgc aatcgcctga gcgccgccca 3407521 ttttgtaaat gtcttttatg cccagctcgg ctgcagcaac caaaactcca ggagacagca 3407581 gaccgtcttt tcccggaggc gtgacgagaa cgattctttc aacgcccgct acgagcgccg 3407641 gaatcacatt catcaaaaca gatgaaggat atgcggccgt tccccccggc acatatacac 3407701 cggcggaatc cagcgccgtc actttctgcc ccagcattgt gccgtccttt ctgtgataaa 3407761 accaggagga ttgcagctgt ctttcgtgat attccctaat attttcgatt gcctgcctaa 3407821 tcacctgaag aagacgtgaa tccagtgagg tgtatgcctc ctcaaattct tcttttgtga 3407881 ccagcgggct gtctatttcg atgcagtcaa atttcgccgt gtagctgcga accgcctgat 3407941 caccgtttgc tttaacatct tcaataatgg accggaccgt ctttctttgc tcttccgttc 3408001 cggcatcgat ggaacgcttg agagaaagcc gttccgctcc gctgatggtt ttgatcttca 3408061 ttttgccgtc tctccttcca caacgagaga taggcgggat gccatttcgt caatcacatc 3408121 gtctttcatg cgatagctta ccgggttgac aataaagcga gaggtaatgt cacaaatgtg 3408181 ctccgtttca acaagcccat tttctttcag cgtctgtcct gtggaaacaa tgtccactat 3408241 ccgatctgca agcccaatga gcggagccag ttcaattgaa ccgttgagct taataatctc 3408301 gacttgttct ccctgctctc tgaaataact ggaagccaca ttcggatact ttgtcgcgat 3408361 tcttggcgct actccgctcc agtctgtatt cggaagtccg gcgacagcta agtggcattt 3408421 gctgatgttt aaatccagta cctcatacac atcgcgttcc tcctccagca tgacatcctt 3408481 gcccgcaatt ccgacgtctg ccacgccatg ctccacatac gtggttacgt ccatcggctt 3408541 cgctaatata aaccgaagat tttcctccgg cacatcgatg atcagttttc tcgaatcttc 3408601 aaactcctca gggagcctgt agcctgcctg cctcagcagc cctgccgctt cttcaaatat 3408661 ccggcccttt ggcatcgcca ttgtgagtaa cttacccatt ttgctcttcc tttctggcac 3408721 cgataaaata agtgacgttt gcaaaagatt ttgtcatctg gtcgatattt tctattcccg 3408781 ataaatcttg aagaaccact ttgttccctt tcatgcgttc ttcattcgca taagcgatgg 3408841 cttgcgcccg ctgctctttg ctgaaaataa cagcgtctat ttcacaaggt tcgtccttca 3408901 tatgaagggc ttcaatcagc cggtcgatcc gaagcccgaa gcctgttgcc ggtgcaggtg 3408961 aatcaaaatg gcccagcagc ttgttgtaac ggccgccgct tccaatgaca aaaccgacat 3409021 tctcggcgta cacttcaaat aaaatccctg tgtaatagct catgtggctg accatattca 3409081 gatccaggcg gacattttcc gtacatccgt aatcctcaag aatgtcccac agcgccttca 3409141 gctcatcaac cacgcttttt ccttgcgcag aatcgacgat ttcctcggca cgtccgcata 3409201 cttctatacc gccccgcagt tcaaggagct caagcagcct gcttttatca atggaggaaa 3409261 gcgggagaga cttgacatgc tctctgtagc cgacgtagtt cttttcatat aagaacctcc 3409321 gcagcacatc agctcgttca acgtttccga gcacctcaac aaacaaagca tccgcaatgc 3409381 cggcatggcc aattgcaatt ttaaaggatg ccagcccagc gttttttaat gccccgacga 3409441 ctaaagcaat gacctccgca tccgcgctcg tcgtgccgtc accgattaac tccactccga 3409501 cctgctcgaa ctcagccgga cgtccgcctt cacgctcctg agccctgaat acatttgccg 3409561 catagccgac tcttagcgga tgaccgtgtt tcagaagctt cgatgccgcc acccttgcaa 3409621 tcggccccgt catatccggg cgaagcacca atgtcttgcc gtcctgatca agtagcttaa 3409681 acagctgctg ctcttcaatt gctgactgga cgccaacggt atcgtaaaac tccagtgtcg 3409741 gcgtttccat aaattgatat ccccatttat caatcaaatc ggttaacgat cgtctcacct 3409801 tttttttcgt ttcgtataaa ccgggcagtg tatctctcat gccgtgcggt ttttcaaaca 3409861 taaacatcaa cccgagcacc tccgctgtta tcttatgaag gaaaattccg aatcctttag 3409921 ttcgctaata tgataatatg ttagcagatg aaagaatgaa aatcaacgct taacttcagt 3409981 aaggatattt ttagttcaaa tatccttctc ctcattatga aaaaatcatg aataatgtat 3410041 taaaggtacg taatatctca aattctttat gtttggcatg ctataataca aatcaaatag 3410101 agaacaagga gataaagatg aaaacactgc gaactctatg tgtcctgatg attctttcag 3410161 gcgttatttt tttcggactt aaaatagatg caaaagatat agatattcct tttttgaaca 3410221 gccttaaaaa agtggtttct gatagcgata cagactcagc tgcgaatagc aaaaaggagc 3410281 tgaagggaag cgcaaaaccg ctggatgtca tcctttacaa tcaaatggac gcaccccggc 3410341 tctataacgg ctgtgaagta acaagccttg cgatggtgct gaattatgcg ggatacgacg 3410401 tgacaaaaaa taccctggca aatcaggttg ccacagtgcc tttgacatac agcagcggat 3410461 taaagggtga tccgaatgac ggatttgtcg gggatatggc gaatggccct ggtctcggtg 3410521 tctaccatcg accgatctat cagctggcga aaacctatgc gggagacaaa gtgtctgatc 3410581 tgactggaaa aagtatttcc gctgtttatc agcagcttga aaaaggcaat ccagtttggg 3410641 ttattacgac agccaacttt acgccagttg acaacatgca gacatggaaa acgccaaacg 3410701 gaacgataga aattacgtac agcgaacaca gcgtcgccgt tacgggatat gatgataaat 3410761 atgtgtatct caatgatccg tatggctata aaaacagaaa aaccgataga acaagctttg 3410821 aaaaagcgtg gaaacaaatg ggcagccagg ccgtggttat tcaaaagtaa acacctgaag 3410881 cctcactatg ctctattctg agcaaatacg acaatattca tgctttttgt atcaatcggt 3410941 aagatcgatt cattttccat ttttcaccca aaattgtctt tactttcagg ctgtctgttt 3411001 ttatgattaa agcagattca gccttgcccc gatctatgcg agagaagccg gtgcaagtcg 3411061 ctgacgcttc tcttgcaaaa aatgaaagat atccggggag gatttatcat tgaaaaaaat 3411121 cgtgtctatc ctatttatgt tcggtttggt tatgggtttc agccagtttc agccatcaac 3411181 cgtttttgca gctgacaaag tggtgcacga aacaattatc gtaccaaaaa atacaacata 3411241 tgacgggaaa ggacagcggt ttgtggcagg gaaagaatta ggtgacggaa gccagtcaga 3411301 aaaccaagac cctgtttttc gtgtggagga tggagcaacc ctgaaaaatg tggtgcttgg 3411361 tgcacctgca gctgatggcg tgcacactta tggaaacgtt aacattcaga atgtgaaatg 3411421 ggaagatgtt ggtgaggatg cgttaacggt gaagaaggaa ggaaaagtga cgatcgacgg 3411481 cggttctgct caaaaagcgt cagataagat attccaaatc aataaagcca gtaccttcac 3411541 agtgaaaaat ttcacggcgg ataatggcgg gaagttcatt agacagcttg gtggttcaac 3411601 cttccacgtt gatgtgatca tcgacaagtg caccatcaca aacatgaagg aagcgatatt 3411661 ccggacggac agcaaaacaa gcacggtcag aatgacaaat acacgctact ctaatgtcgg 3411721 tcaaaaatgg attggtgttc agcatattta cgaaaacaac aacactcaat tttaacaaaa 3411781 aaagtccgct gatgttattc agcggacttt ttcaatcttt cttgcatttc ttccttcgta 3411841 tagatgatcc tcatcggatt tccgccgaca aatgccccgt caggcacatc cttatggaca 3411901 agcgttccgg cggacacaac tgcgccatct cctattttca ccccgggcag aatggtcgtg 3411961 ttggcaccaa tcatcacttc gtccccgatc agaactttgc cgatccggta ttcgtgaatc 3412021 aaatactcat gggccagaat ggtcgtattg tacccgatga ttgtatttgt tccgactgag 3412081 atcttttccg gaaacatgat atctggcatc accatgaggg caaaggatgt ctgttttcca 3412141 accttcatcc gcagaaatgt gcggtacagc cagtttttca tccctataaa cggcgtatat 3412201 ctcgcaattt gaatgacaat gaaatttttg acgaccttta aaaaaggtac cgtttgatag 3412261 acatgccaca gtgagttggc ccccgagacc ggatgacgat ctgtttttct cacagattac 3412321 ttcactccaa cgatttgtaa tagatcactc attttctcaa gcataaaatc cggctcatgc 3412381 ttcgccagca tttccggccc tttaatcgtc catgcgactc ctgccgtttt tgtaccggcg 3412441 tttttccctg ccagcacatc atggtaatta tcaccgacca taatggcttc cgccggctcg 3412501 cttcctagct gtttcagcgc taacagcaca ggctcgggat caggctttgc attcgtcaca 3412561 tcatcaaggg tgacaactgt ttcaaagaat tcgccgattc ccgtgagctt gaggcccata 3412621 ttgacagtat ctcttaattt tgttgtcaca attcctaatg taaagccggc tttttttaat 3412681 gcatccaggg tctcatatac cgtttcatat tcagtgacga gtgaatcatg catgtcatga 3412741 ttgtacgctc tgtacatagc gatcatatcc tcgcatttat cagggtccat cgaagagaac 3412801 gtatcaaaaa gagacggccc gataaatgca aggacatctt ctcgtttata cttgctcgga 3412861 taataatgct ccagtgtatg caaaaaggac gcgataatta attcattcgt attaataagc 3412921 gttccgtcta aatcaaacag aatcgtcgtt acttgtttgt cactcatatt gcttcctttc 3412981 caaccgctga gggtttccat tttttccacg tgtgcgcaat agccattgtc agcagaactg 3413041 ctgtggtgac acgaatcaaa agaagcggcc agaccggtat gccaagcgga ataaagacaa 3413101 gtgtatcttc cacgaccgcg tggcaggcaa cgagaaatat aaatgccaat gtcatgtccc 3413161 gcttgctcac gccgtcatcc tcgacagctt tgatcatgac acccgctccg taggccagac 3413221 caatcgtcag tcccgtcacc atcgtcatag acgtattttt attcatgcca agcagctgcg 3413281 taaacggcga cagccacctg gaaaaccgat aaagccagcc taaatctctt aaaaactgga 3413341 tgataatcat cagcgggatc actattgccg ccagctgcaa aacaccaagt ccggctttcg 3413401 ttaatgcttc tgccaacatt cctagccagc tgtctggcgc cgcgctcttc gcagcgataa 3413461 aaccgtactg cgccgtttcc tttccgccat gccaaatgag gttgatgacg atggctgaca 3413521 cagcggccaa accgatgcgc acggccaata tgacgccaat tctgatacca acctttgcgg 3413581 caactgtcga ttcgataatc aagttatgac agaaagaaag cataacagct aaaataaaga 3413641 cttctttcac agataaatcc aatgttaaaa tcccggcaat tcccgcatac agattcagca 3413701 tatttcccag tacaagcgga atggccgctt caccagaaag cccgaagaga cccattaccg 3413761 gtgtgatcag ccgtacaagc caatccatga caggggtatg ctggagcaaa gtgaccaata 3413821 gcgttaccgg gaaaatcact ttacccagcg tccatgttgt ttgaaaacct gctgcaagac 3413881 cggccagaaa gatcttcttc atccctcatc cccctttgtt gacgtctact ccgcgtaccg 3413941 ctccttcgag tatcccttga cgcgtctgaa gatgatggct gccacagcca aaacaatcaa 3414001 tacgattgaa atcacctgag cgatgcgaag tgaatcagtc agcattaagc tgtcagtccg 3414061 cattccttca ataaagtatc ttccgattga ataccaaatg atatagatca agaacatctc 3414121 gcctctacgc aaattcgctc tgcgcagcag cagtaaaaca atgacgccga caaagctcca 3414181 tagtgattca tataaaaaag taggatgata atattgccca ttgatataca tttgattgat 3414241 gataaattca ggcaggtgca ggttttctaa aaaggctctg ctgacagcct cgccgtgcgc 3414301 ttcctgattc atgaagttcc cccagcggcc gatcgcctgg ccgagcaaaa tgctgggcgc 3414361 ggcaatatcc gcaagcttcc agaacgaaag gtttttcact ctcgaaaaca cataacccgt 3414421 taaaatggcg ccgattaatc cgccatgaat ggcaatgccg cccttccaaa tcttaatgat 3414481 ttctcccgga tgtgccgcat aatagtccca ttcaaaggca acataataaa ttcgtgcgca 3414541 aataatcgca attggaatgg caaacaggac aagatcaata aacgtatctt tctgcagccc 3414601 ccgtttttca ctttccctca tcgctatcca cagcccgagc aaagcgccga gaccgataat 3414661 gattccgtac cagtggacgg ctaacggccc cagctgaaat gctatcggat tgagtggttc 3414721 tatcgcttca ttcatttaac gccaactcct attcttcttg ttcaccgtct tcaatgacgt 3414781 ccgccagctt gttggtaaat tgttcagcgg cattcagccc catccgcttc aatctgaagt 3414841 tcattgctgc cacttcgatg atgactgcaa gatttcggcc tgggcggacg ggaatcgtca 3414901 gttttgtaat ttctgtatca atgattttca tggtctcttc ctcaagtccg agccggtcgt 3414961 attgcttgcc ctgctcccag agttcaagat tcatgacaat cgtgattcgt ttattgcttc 3415021 tgaccgcgcc agcgccaaat agcgtcatca cattgataat gccaaggccc ctgatctcaa 3415081 gaaggtgctc aattaattcc ggagcgtttc ccacaagagt atcctgatcc tcctgccgta 3415141 tttcaacgca atcatcggca acaaggcgat gccctctttt cacaagctct agcgctgttt 3415201 cgctttttcc gacgccgctt tttcctgtga tcagcacgcc gacaccatat atatcgacaa 3415261 gaacgccatg aattgctgtg gtaggcgcca gcctgctctc aaggaagttg gttaaacggc 3415321 ttgacagtct tgtcgttttc agcggcgatc tgaggacagg caccccattt ttctcggagg 3415381 cgtcaatcag ctcctgcggg atgggcatat ctctagaaag aataatagct ggtgttacat 3415441 cagtgcacag agaatccatt cgctgctttt tctcctcttc aggaagctgt tcaaagaaag 3415501 aaagctctgt ttttccgaga agctgcacgc gctccctcgg gtaatatgta aaatatccgg 3415561 caatttcaat acctggtctt gataggtcac tcattgtaat cgggcggtta attccttctt 3415621 ctccgctgat taattccaaa ttgaactgtt ccattacgtc ttttgtgcga acctttgcca 3415681 cgatatgttc ctcctgttcc gggctgcccc gagcttgctc acaatacttt cattttatca 3415741 ctttcgggct tgaacctaaa acagatttta taaaaggggg gaaaacacct cagctggtct 3415801 agatcactag tctgaaaaag agtaaaataa aggtattcaa attccagaaa ggcggatcat 3415861 ctatggcaga gagtcttctt atcaaagaca ttgcgatcgt gacagaaaat gaagtaatca 3415921 aaaacggcta tgtcggaatc aatgacggaa aaatcagcac agtttcaaca gaacggccca 3415981 aggagccata ttcaaaagag attcaagcac ctgcggattc cgttttgctt cccggcatga 3416041 ttgacattca tatccacggc ggctatggcg cagatacaat ggatgctagc ttttccacgc 3416101 tcgacatcat gtcgtcaaga ctgcccgaag aaggcacgac gagcttttta gccacaacga 3416161 ttacccaaga gcatgggaac atttctcaag ctttggtgaa cgcaagagag tggaaagcgg 3416221 ctgaagagtc ctctttatta ggtgcagaac tgctcggcat tcatttagag ggcccctttg 3416281 tttcgcctaa aagagccgga gcgcagccaa aggagtggat taggccttcg gatgttgagc 3416341 ttttcaaaaa gtggcagcag gaggcgggcg gactgatcaa aattgttaca cttgcgccgg 3416401 aggaggatca gcattttgaa ctgatccgcc atttgaaaga cgaatcgatt atcgcatcca 3416461 tggggcacac ggatgccgat tccgcattgc tgtcggatgc cgcaaaagca ggggcgagcc 3416521 atatgactca tctgtacaac gcgatgagcc cgtttcatca ccgagagccc ggagtgatcg 3416581 gaacggcgct ggcccatgat gggtttgtga cagagcttat cgccgatggc attcactccc 3416641 atcctttagc tgcaaagctt gcttttttgg cgaaaggcag cagcaagctc attttaatta 3416701 ccgattccat gagggcaaaa ggactgaaag acggcgtata tgagttcggc ggccaaagtg 3416761 tgacggtaag aggacgaaca gcacttcttt cagacggaac ccttgccggt tcgatcctca 3416821 aaatgaacga aggcgcacgg catatgcgtg agtttacaaa ttgctcttgg acggatatag 3416881 ctaatataac ttctgaaaac gcggccaaac agctgggcat ctttgaccga aaaggcagtg 3416941 tgactgtggg aaaagatgca gatttggtga ttgtcagcag tgattgcgag gtgattctca 3417001 ccatttgccg cggaaacatt gcatttatat ccaaggaggc tgaccagata tgaaagtaat 3417061 ggaatgtcaa acgtatgaag agctaagcca aatagcagcc agaataacgg cagatacaat 3417121 caaagaaaaa cctgatgctg ttctcggttt agcgacgggc ggcacaccgg aaggcacgta 3417181 tcgccagctg atccgcctgc accaaactga gaatctctca tttcaaaaca tcactacagt 3417241 taatttggat gagtacgccg gactttcaag cgatgacccg aacagctatc acttctatat 3417301 gaacgaccgt ttttttcagc atatcgacag caagcctagc cggcatttta ttccgaatgg 3417361 aaatgcagac gatttggagg ccgaatgcag acggtatgaa cagctagtcg attccctcgg 3417421 cgacactgac attcagcttc tcggcatcgg ccgaaacgga cacatcggct ttaacgaacc 3417481 gggaacgtct ttcaagtcgc gaactcatgt tgtgacatta aatgagcaaa cccgccaagc 3417541 gaatgccaga tattttccct ccatagacag cgtgccgaaa aaagcactga caatgggaat 3417601 tcaaacgata ctctcaagca agcgcattct gctgcttatt tctggaaaaa gcaaagcgga 3417661 agctgttcgt aagctgttag aaggaaacat aagcgaagat tttcccgcat ctgctttgca 3417721 cctgcattcc gatgttacgg ttttgattga tcgtgaagcc gcgtcattaa gaccttgaaa 3417781 ggaacatgct gacttatgaa tatcaataaa caatcgccta ttccgattta ctatcagatt 3417841 atggagcaat taaaaaccca aattaagaac ggagagctgc agccggatat gcctcttcct 3417901 tctgagcgcg aatatgccga acaattcggg atcagccgga tgacagttcg ccaggcgctt 3417961 tctaatttag ttaatgaagg cttgctctat cgcctgaaag ggcggggcac ctttgtcagc 3418021 aagccaaaaa tggaacaagc acttcaaggg ctgacaagct ttaccgagga tatgaaaagc 3418081 cgcgggatga caccgggcag caggctcatt gattatcagc ttattgattc aactgaggag 3418141 ctcgcggcta tattaggctg cgggcacccc tcctctatcc ataaaatcac tcgggtgcgg 3418201 ctggcaaatg atattccgat ggcgattgag tcctcacata ttccgtttga gcttgcgggt 3418261 gaattgaacg aatcgcattt tcagtcgtcg atctatgatc atattgaaag gtacaacagc 3418321 ataccgattt cccgtgcaaa acaggagctt gagccaagcg ctgccaccac ggaagaagcg 3418381 aatattcttg gtattcaaaa gggagcgcct gtcctattaa ttaaacgaac aacatatctg 3418441 cagaacggaa ctgcttttga gcatgcaaaa tccgtataca gaggcgaccg ttatacattt 3418501 gtccactata tggatcgtct ttcataaaaa aagcctccaa ccctttttaa ggattggaga 3418561 catggcgaaa atcaaactgg tctggtgccg gacgatatgt ttcttttttc gtcttgaact 3418621 tccagatcgg tgatttcgtt ttgccgttaa aactgtcttc cactataatg taccaataat 3418681 aaacagactg cggttcaaga tgatcccagc ggaattcagc tgtgtccccg ctcttcactt 3418741 gctcccgttt tccgagctct tcattggtat atacgttaca ttcaaaataa tcggtttcca 3418801 cctttttgat tcttggcttc aaatcaagcg aaagggaaaa ttcatccttg ttgccatagg 3418861 tatccgtatc atagtagttc ttatccttta catacggaga gtacgtcgat acgtgcacca 3418921 tgtcattggc ttggtcaaat tgaagcaaac gcaaataccc ttggccgcct tctggcccgc 3418981 cctgataatc ggccagcatt tgatgcacaa gacgatccgg tttcccatca ccatcatcat 3419041 ccagctcatc tgtttttctc atcgcactat gataatgccc gctcaacacc atcacgacat 3419101 tcgggttcgg ctttacgatt tctttgaata ttttctctcc gattgggctt ctgtttccgc 3419161 tgaccagcaa atactcatga aaagctaaaa tggccatccg gtcaggatgc ttcttcagca 3419221 cctgattcat ccacgcgatg tcttcatccg taatgcccca tcccatgtac agcatgatat 3419281 aatcattgcc gttgctagaa atcaggtcat aatgtccgcg gttattttta taggaaccgc 3419341 cataatgaaa ttttttatca aaacgatcgc tgccaaaata tttgccaaac gccctgtagg 3419401 agccgtcctt atgtccgaca tcgtgattgc cggccagcac gccgtaagga attccgctct 3419461 tatccagaac ggacattgac cgatcagcgt ttttccactg tctgatatcg gcggaatcat 3419521 ctacaatatc acccgtgtgg aacacatatt tgatattgag ctgcttttga ttatctttta 3419581 tccattcggt ctgtttatca aaaatatgcg gatagctttc ggcgtaatac tgtgtatcag 3419641 acatccagac aaatgtgtac atatccttcg caggaggaat ttcatcctgt acaatcacat 3419701 tcattttcga ctcccgtaca aaatcggcgg caatcacaga cgctttcagc gtaaacggtt 3419761 tgtcatcctt cgcgacgaag ctgtcaacag gctgccattc gtttgtccga taattccaag 3419821 catacatcgt cacctttctc cccggcaaag aactgccctt ccagactgat tctgccagat 3419881 cattctcatc aattgatgga tcaaccgtca cttcaaagcg atgataaggg aaaagctctt 3419941 tgttttctgt cgatactgtt tttccatcag cagctgatac ccgctccaat tctttattcg 3420001 taaatggggt ctccctttcc ggcacaaagc ttttcggcgg ttcagtcagt gacgcgtgct 3420061 taaatatttt cacatgattg cgcgctgtat attgaaatcc cctataaaaa ccaacatcca 3420121 tggcatcatt cgtcggatct ttcacccgta cagaaagctt ggccttatgc gtgtcggctt 3420181 cgctgtctat aacctccggc tggtccggat gctctcgttc ggttttaaat atcctctcaa 3420241 tcactgtttt attgcccgcg agatccgttg ctgtcacttt tagagaatgt tttcccggca 3420301 aaaggtcaga agatgacgta tgatatggga gtgtaatgct ttctccatct aacgacgcct 3420361 ccgcttcctc aattctgctc catttatcat acatatccgc ctgcaggata aggtttcctt 3420421 tatacgtttg cccctcggtg atattcggct caatgtgagg tcctgaatta tctacccgta 3420481 caaccaggct gacattttcc ttcccgtcgc ttgcttgaat atggtgagcg ccttcagaaa 3420541 gctttgatgt atcccactcc agcagctgtg atgtaaatag tccgtcaggc agattgaact 3420601 gaaattgcca gcttttattc gagcgctgat tatcgccaat aaagagttcc ttctcaggag 3420661 acaccctctg atctctgatc accgttccat ccgataacac caatcgggcg tttttgacta 3420721 agaagtcatc acggttttca gccgtatcaa acggagacac cttcgaacct gaacgtatcg 3420781 taatacgctg cagctgcttc cctttccgaa gcagtgtctc tggcaatgga acagaatagg 3420841 tgcggtattt atttgttgta tcatcgaaca ccttcagcac tttgccttcc atcgttaccg 3420901 cgtttttaaa ataaaggttc gttttcctcg tatcgaatgc aaaatatact tctttttcca 3420961 tcgcgggctc tgtcacttgt tttttcccgt caatccatag cttaatgctg tcagctcgcc 3421021 cttctgtcgt ggctttgaga aattgagttc ccgacagcgt gtctctgttt tcaatattca 3421081 tccgcagacc gtgcgccttg cttgtttgtt taatatcaat cattttgacc ggcgttctcg 3421141 cttcattgat cccgtccccg gccgccacat aatactctag ctgatccttc ccgatcaatt 3421201 caggcgaata cacaatataa tggaagagat tatcgttgcg gtctttttca gcaagaattc 3421261 gcttaaacgg tttgttctca tccgtccggt agtaaaaggc cactgttttc actaggcttc 3421321 ggtcccgtat gtcagcccgc agctcaatgc tttcagcagg gcggacaggc ttgcggtcag 3421381 tcaaatcctc aatgaccggc ttttctttat cgagcttgat tttccgtttc tggtcgggca 3421441 cctgtgcctg taatacggtt ccgggagacg gattcttttc cccgattgaa atgttcagaa 3421501 gttctgctgt tccgttcagt ggatacttat aaagcactga tgacagccgg cgcagcgcat 3421561 gtttccgata atgcgcaacc gaaatgtcct ttcctgtatt cgttgatatc acaacggccc 3421621 gcggcctcgt attggccata ccctctgtct cgtctatcac cgcaagattt tttccttctt 3421681 ttagttgtgt ctgataataa cgattgaaat ccgctgacgt caattctgga tgcccggcag 3421741 gcttcagcca gacgacaaac gtttcgccgg atggtatcaa gatcctttca tcaggtctcc 3421801 aaatcagatc ggagtcaggc ccttcttttg ggtagcggta acggatatgg tagtctttaa 3421861 aatcaatcgt tctgtcagtc gtattaaaaa tctcaataaa ttcataaccg tctgcgcgtc 3421921 ctatattctt cgtatcaacc gccagctctg tgatcagaag ctccggaata tgggcaaggt 3421981 cagcctggta tccttcaagc ttcagtttct tcgtctccga ctcaacccgc tgcttcccat 3422041 tcgacatcac aatgtaatac tcaagctcgc tgttccaaat caaacgtttc ggaatttgtg 3422101 ccaaaaactt gcggaccgct ccgggggtcg ggtccatcgg caccattttg tagcccagct 3422161 cattactttg tttataaaaa agaaaggcgg aaaatgcttg atacgaatta tcgcgaactt 3422221 gagcctcaat cattagattg cttctcattt cagctttcac atcaatttga ggaggatttt 3422281 caagcaaggg tatgtaatga ggcgtttgaa atagttcctg ctgtacaaca ggaaaagctt 3422341 tcgattcatg atggccgcca gacaaaacgg aaagaaaaga cagtaatata gaagcaataa 3422401 ccgtgtattt cctcatcaaa gcacctccct tttcatgtat tttgcgtctg aacagggaag 3422461 cttatgagtt catttttgtg cataaagaac aaaaaaacgt ctgtctcttg aaaattccac 3422521 tattacccag taaactaagg atagttaacc agttaacaat taaatcagag aggcaaattg 3422581 atggacaaca gcattcatga tgaattattt caagctatac aacaattcgc attaaaaagg 3422641 gataaacgcg tctggcaaaa ggtgcagata ccatccattg gcatatcctc acaacatcac 3422701 gatcacctca aaaaagactg gactttgacc cagcttcaca ttgtttcctg catacatacc 3422761 agccaaaatg tgaacaacag cttcttagca tcccgtttac acatctcaaa agccgctgtt 3422821 tcaaaagcgg ttcatgcttt gttgaaacac aatatcatta cagtgacaaa aaagcctggc 3422881 aacaaaaaag aaatttttta tacgctaact gatagcggca gaaaattggc ggcattacat 3422941 gaacagcttc atgagaaagc aaaggagcaa tataaacagc ttttcaatga attttcaatt 3423001 gatgatttaa aaacagtgac tgcgtttttc aacttgtgga tcaaatatat gtaaaaagag 3423061 tctcacccgc atgggagaga cctttggaat tctattatgc cccgtcaaac gcaacgagaa 3423121 gtgaaacagg tccgcgtgta tacagaccgg actcagcata acaaaaatct tcctctaatc 3423181 tgatattccg catcttatcc agcacaatat tagctacaat ttcgatttcg tttttggcaa 3423241 aagctgctcc tacacagtta tgaatgccgg atccgaaagc gagatgccgg gcggcgccgc 3423301 taaaagcgct cttgatacca agatcttccc gatgaatatt aaacacgtca ggctgttcaa 3423361 atgcttcagg gtcccggtta gccgcaccga tcatacaaaa aacaatcgta tcttttttga 3423421 tttccatacc gccgaccact gtatcttggg acagctgccg cggaatcagc tgaaccggcg 3423481 gtttataacg caatgtctcc gcaatggctc tcggaactaa cgaacggtca gccaaaacat 3423541 cattcatctg ctcaggattg ttgagcaaat ggtagatcat cagtgccagc gtcttatcag 3423601 ccggttccgt tgcggctaac agcacattaa gaatcagtgc gagtatatcc ttgtccgaca 3423661 gcgccatgcc ttcatattca gaagtacata ggatcgaaat taaatctgat cccggattga 3423721 cgcgacgttc tttaatgacc ggcatcaagt attgggaaag ctgttcgctg caccataacg 3423781 aatgtgcccg cgcttcagga gattgagaga tactcgtgat aaaatcggca actccgctgt 3423841 gccactcaga gattttttca tggtctcttt tatccagccc gagcatgtcc atcgtgacgc 3423901 acaccgcaaa cgtctttcca aaatcattga cgagatcact tttccctctt tcaagataag 3423961 gcgctaacaa gttttctgca ttttgtttaa tcaatggaga cagatgatcc agtgcgtcac 3424021 cgataaagct tctcactaca attcttcttt tggcagagtg ttcttttcca tgcatttggg 3424081 ccagcacagg gcctcgcatg actggttcgg cacgctcaac aagtgatttc gtcgtgaaga 3424141 tatccggatg ctgaaggata tagcggacat catgatagcg gctgataaaa taactgtcta 3424201 tcgactcttc ataatgaacc ggatcttcct cccgcagttg tgaaaaataa gcatatggat 3424261 tgttttgaaa ttgatcagaa agcacactaa acaatttaat cgattggctc atgttttact 3424321 ccccctatca tccttcagat gtgatccgtt tctcagaaag catctgcgcc atttcctgta 3424381 caatgagata cccttgattc ggccgcatac aaatagaaaa ttcatggtta ctgatcttct 3424441 cacccagctt ccacggacga tgataagcaa ggagtgtctc ttccacctct aaaatatccg 3424501 gagctccgat aaaaaacggc agctcagcta tgacatattc cacagccaaa ttcagcatat 3424561 cctcactgac ttcttccatc atcaaactga cgccccgcgc acgcccgatt atcgcttcac 3424621 gagacatgtc caaacaagca tgtcgaaaat gaggctgctc aaaaaatgca tgttcaactt 3424681 cttgtctcaa cagctggtag gctttgttat ctataaaatc agaaaatgta tgaatcgcct 3424741 tcggatcccc gccatgagcc acaagggctc tttctgcaaa tctcctgttt cgtgatacct 3424801 ctttccttac ttttcgttca gcctttcctc tcggagttcc aagcgcttct agaagattag 3424861 ccgcctcatg ccctgcaagt aaaactgaaa cgcttttaaa ttgagctttc gcccatccaa 3424921 ttaatctgta aatataatcc tctgaaaacc tgctgttaaa tgggctgatc cccaccaaaa 3424981 catgcctgcg ccgttcaaat atttctctgc agttttctgt taatgcctca gcaataaaat 3425041 gcacagacct tctttccgtt accattccgg tcatctcatt cacccctaaa acttatcccg 3425101 ctttaagtca tcaccctcaa atacaagatg gaatagctag aacaactgaa caagacgaat 3425161 ggcaggcatc acttaaagtt tccaaatgtt ttttaagatt ttaataatca ttttcaatac 3425221 ccatatcatg ataaatgttt actagtaaac attagtcatt ttatcccttt tccttccaaa 3425281 cgtcaatatg atctgtgccc aaatatttga aaataaatgt aaacatcaca ttttccacac 3425341 actttttaca cgcatattca gcatgacata tcaacaaata gtctaaacac caacaattga 3425401 caacgaaaac aagaaaagat aaaataaaat tgttcaccag taaacgattt gttttattgt 3425461 ttcatcgtaa actattattc ctaagaaaga aggtagccta tgtctgattt gacaaaacag 3425521 atgatatacg acatatacgt gagactgctg caccttaatg aacaaaaagc gaacacttca 3425581 cttcagcaat tttttaagga ggccgcagaa gaggatgtag ctgaaattcc caaaaatatg 3425641 acaagcattc acgtcattga ctgcatcggc cagcatgaac ccattaataa tgccggaatt 3425701 gccagaaaaa tgaacttatc gaaagcgaat gtaacgaaaa tcagcacaaa actgatcaag 3425761 gaagaattca ttaacagcta tcagctgaca gataacaaaa aagaagttta ttttaaatta 3425821 acccgtaaag gcagacggat tttcgactta catgagaaac tgcataaaaa aaaggagctg 3425881 gctttttacc aattcctcga ttcattttca caagaagaac aaaaggctgt attgaagttt 3425941 ctagagcagt tgacgtcaac acttgaagca gaacaaaccg atgggactcc agacaaacct 3426001 gtaaagtaaa caaaaaggcg gtgtacactt tggctcatac aaaatcaaag gcagtattga 3426061 tcttatacac tgtttgcttc agtgcatttt ttgcatcttt aagccagaac atttattcac 3426121 ctattcttcc gatcattaaa gaatcattcc atgtttccac agctatggtg aacctgtcag 3426181 tctcagtttt tatgattgtg acagcaataa tgcaaattat attaggagcg atcattgatt 3426241 ttaaaggcgc tcggatcgtc ttgattaccg gtattctggc aacggcagca gccagcatcg 3426301 gctgtgcggt gactactgac tttaccttgt ttctgatatt cagaatgata caggcagccg 3426361 gttccgcagc actgcctctt attgctgcca caacgatcgg acagctgttt acaggaaatg 3426421 aacgcgggag tgcaatggga acgtatcaaa tgctcctgtc tgtcgcaccg gctattgctc 3426481 cagttctagg aggattcata ggcggagcag ccggatacga agggattttt tggatacttg 3426541 cggccatctc tatcgttttg ctggtgacaa acagcatcac ctttcctaaa gattctccaa 3426601 ctgaatctat gcagcaagcc aaaggcaatg tgttcgctca ttataaatca atatttacaa 3426661 atcgaacagg gaacgtcatt ttgactttaa gttttgttct ctttttcatt tattttgcag 3426721 taattgtcta cctcccaata ttgctgacag agcattacca tatagatgtg ggtatagcag 3426781 gactgttata tttgccgctg gcgctgagca cgattgcagg tacgtttctg tttaaaagaa 3426841 tacaggcaaa aatcgggctg cacaccttgt ttatcggaag caatgtgatt gccgcctgca 3426901 gcatcatttt atttgctgtt acacattccg tttctctcgt tctcatggct ctgacgctgg 3426961 cactgtttgg catctcgatg ggggttattc ctcccttgta ctctacaatg attactaatg 3427021 aatttgagca caacagaggg agtgcaatcg gaatgtttaa ctttatccga tatacaggca 3427081 tggcagcagg tccgatggta tctgcctact tgctcacaat gatgccgtct gccatgtcct 3427141 ttagcctcct aggccttgga tttgccgcat tgagcttttg ccttcttccg ccaatgtttt 3427201 cgccgcagaa gcgcacgaaa caaaaaaagc accacatgta aaaaagctgc ctttgcgggc 3427261 agcttttttt atttttttct aagcggctct aaaatgcctt tttgaatcag caaatggaag 3427321 accgacagga taacggatgc ccatatcgct gtgccgaagc cgtcgatttg aaagctgtca 3427381 cccataatgg acgcggtcat cataagcgtg atggcgttaa tcacaaacaa gaagagtcca 3427441 agcgtcacca tggtgaccgg cagtgtaaat ataattaaaa gcggtttaat cagcacgttt 3427501 aagatcgata aaatgaggct ggcgataatc gctgccccaa tgctgctgat atggatggag 3427561 tcaatatatc catcaatgac gattaataac aatgcattga ctaaaatgct gactgcccat 3427621 tttaccatgt catttcatat ccctttctga cgggacgata aaaatccaaa tgatataaat 3427681 gagcaaaacc ggcaagacac ttgtcataat ggctaagatg acagttatga ctctgaggag 3427741 tgatgcgtcc caattgaaat attccgcgag acctccgata acaccggcga ttttcttatt 3427801 tttttctgag cgataaagct tattcattcg atcacctctg tgagtacttt agtttgatgg 3427861 cgcctgttag tgattctgag aagacggtga tgttttgatc atgtgcctga tttgaagtga 3427921 acatcatttc tttttgaatc gtatcatttt tttccttcag catctctaca tccattaatt 3427981 catgggacag cgtaccaaga ttgcttttca gctctgcctt cactgcgaga tcgtccggaa 3428041 ttgcaagctc tacatttcca gtcgttgttt ttgcataaat ggagcggcag tctgattctg 3428101 ttacgttaat cgcaatattt ccgttaaagc tttgaacgtc aatggattcg cttttccctc 3428161 ggagatcgat caatccgtta atggtttccg cttctatcgt accgcagctg tggcttgcga 3428221 gcttaatttg cccgttggcc gtttcagcta tggctttttc ggctgttaaa tacgagaacg 3428281 acagcacgcc gtttgtcgtt ttcgctgaga actcttttac atgtaaatgt tcccctctga 3428341 ctggaccgtt aaacagcttc acccgaatct tatcatactc cttctgagga atatacaaag 3428401 tgacattcgt tttcatcgtc tttttctcag tacggataaa aaacttatta cctttgattt 3428461 cacattcaat atgctgaaga aatgcgtgtc tcgccgcatc ctggctgtca gcgcgatata 3428521 ccttcgcctg gcattccgct ctgatatcgt catcttccca agggacgata tttacgctgc 3428581 cattggcaat ttgcagctca acactggaaa agtcagtatc tttaaattga aaaatgtgct 3428641 gaacatcata cgcatggcca aagtttaaat caaggtcaac ttccttgacc tttttcacag 3428701 cagaatcaat ccagtcaaac agcttggctc ctaaagacgg tttgccgctt tctttttttg 3428761 ccgttgtaaa tggctcttcc tcgtcatgaa cgtgaactga gagcgctgtg attttctctt 3428821 ctttttcctt gtagtcgctg tcaagctttt caatcagtgt caaagcttct tgtgctgtaa 3428881 gctttccttc ctcaacaagc ttaaggattc gttccttttc ttgcttcatt acgatctcct 3428941 ccccattgtc tacttatgct gcacgcagga ccttaatgcc ctgaatcaca ttccaaatga 3429001 taatgccaat gacaactaag aaataaataa ccgctccccc gatgattaca aatacaggaa 3429061 gcaagctgtc tccatcaatc gcaacggctc cgccaagtaa agcaataaaa aggaacagcc 3429121 agccgacaaa cggaacaatg tgagaaataa gagagcgtat cgcatggcgt tttgtttctt 3429181 tctcatttac aacaaaatat gcgacaatcg gcacaatgat tggcgcaatg aacacactga 3429241 aataacaaag tgatgcaata atagcttgat tacggttcaa ttcattccac actcctattg 3429301 tgaattgtcc atgacaaaag atcagggacg ttttacttat ttatacgttt aaaatctctt 3429361 caggtttcaa attcattctt tagacatgct ccgatttacg gaaattggat tttaaaaagt 3429421 tttagaagta gaatcttccg gctataccga ttacaatatg taaaaagctt acggcaacca 3429481 aggaggctgg acaagcaatg gagaaagatc ccagtgacta tacagtaaca caagaatcag 3429541 tgttaaagct gattcaggaa caaaaaagaa tgaatcgtga aatgatcacc gagcttgagc 3429601 agattcacgg acccttcccg atctctcacg atatccaata tataaaagtg ctgctcgaca 3429661 gcagcaacac acatattgtt caagatttaa tgagtgtaag taagcagctg tataagaaga 3429721 ctttgtaatt gcggaaaaca tatcattcat tataactgaa acaaagctaa aggttagatg 3429781 acaatatctt gccttttttg ttttgaaaaa acaagtgatt ccctggctgt cacaaaatga 3429841 ttgtaacaaa aaaagcctgc cggcacatcc agttaatgga ctctgtcggc aagctgtaac 3429901 tatcagaaag agatagccgt tcaaaattaa cgtaacaatt gaagcacgtt ttgcggctgt 3429961 tggtttgctt gagcaagcat cgcttgagaa gcttgagaag gaatgttgtt ctttgtgaac 3430021 tcgctcattt ctttcgccat gtcaacgtca cggatacggg actcagcagc tgtcaggttt 3430081 tcagaagaag caccaaggtt gttgattgtg tgctctagac ggttttgtac cgcaccaagt 3430141 ttagcacgtt ggtttgagac attgttgatt gcagtatcaa tactttcaag ttgtgtatca 3430201 aaaggagtat tagcaaaatc tgttacatta agtgcgttta ctcctaaagc agttgatgac 3430261 atgctgtcaa tgttaactgt aagctgctgg ccagcatttg ctccaatttg gaaagtgaaa 3430321 ccatcagttt cagtaccatc taataacttt ttgccgttga attcagtacg atttgaaatg 3430381 ccatcaactt cctcaataag cgcatccatt tcatctttaa ttgcaccaag atcttctgct 3430441 tgttgtgtac ctgtgtttcc tgcttgaaca gtaagttcac ttctaaacct attatgccgt 3430501 aaagaaaaag cttgcctgct aagcccaagg atggacttgc cgacaagctg tcccctctta 3430561 acagagggtt ttaagatgta gctgtttctt ttgctttcaa gagcgatttc atgcgtgttt 3430621 tgtcacgttc gataacaggc tttaaataac ggcctgtata cgattcttca acttcagtga 3430681 tttcctcagg cgttccagac gcgacaatgg ttccgcctcc ggctccgcct tccgggccca 3430741 aatccacaat gtaatcggcc gtcttaatga tatcaagatt gtgctcaata accagtacag 3430801 tgtctccgtt gtctaccaac cgttgcagca cgacaagaag cctggcgata tcgtcgacat 3430861 gcaaacctgt cgtcggctca tctaaaatgt agagcgtacg tccggttgag cgtttgtgca 3430921 gctctgacgc gagcttcacg cgctgcgctt ctccgcctga caaggtcgtc gccggctggc 3430981 cgagcgtaat ataacctaaa ccaacatcat aaagggtttg gagcttgcgt ttgattttcg 3431041 ggatattttc aaagaaagaa agagcatctt caaccgtcat atcaagcaca tcagagatgc 3431101 tttttccttt gtacgtcact tcaagcgttt cacggttata gcgtttgccg tgacacacct 3431161 cgcatggaac gtatacgtca ggaaggaagt gcatttcaat tttaataatc ccgtctccgc 3431221 ggcaggcttc acatcgtccg cccttcacgt tgaagctgaa acggcctttt ttatagccgc 3431281 ggaccttcgc ttcatttgtc tgcgcgaata catcacgaat gtcatcaaat acaccggtgt 3431341 atgtcgcagg gttggatctc ggcgttcttc cgattggcgc ctggtcaatg tcaatgactt 3431401 tatctaaatg atccaaacct ttaatctctt tatggctgcc gggcttcgct ttcgctttat 3431461 gaagcttttg cgccagcgcc ttatgcaaaa tttcattaac gagtgtactc tttcctgaac 3431521 cggaaacacc tgtaactgct gtaaacgtcc caagcgggaa cttggcattc acttttttca 3431581 ggttgttttc tgatgcacct ttaatttcaa tgtaacgtcc gtccggcttt cttctttcag 3431641 gaggcaatgg gataaacttt ttccctgata aatagctgcc cgttaatgaa tttggatctt 3431701 ccatcacttc ttccggcgta cccgcagata tcacctgtcc gccgtgaatg ccggctcccg 3431761 gtccaatatc tattaaataa tctgctgcca tcatcgtgtc ctcatcatgt tcgacaacaa 3431821 tcagcgtgtt cccgaggtct ctcatatttt tcagagcgct gatcaagcgg tcgttatcac 3431881 gctgatgcag accgatagac ggctcatcta aaatataaag cacaccggat aaacgcgagc 3431941 caatttgagt cgccagcctg atgcgctgcg cctctcctcc ggacaatgta cccgctgccc 3432001 tgctcaatgt caggtaatcg aggccgactt tgtccagaaa gcttaagcgc tccacaattt 3432061 cgcgcaaaat caaattggcg atctgcatat ccttctcaga aagggtaaga tctttaaaga 3432121 aggcaagtgc gtcggcgaca gacagctcgg taattttccc aatgtggcgg ccgtcaatca 3432181 gtacggcaag cgcctctttc tttaaccgat agcctttgca cgtcggacaa gacttctgag 3432241 acatatactg ctccatttgc tcacgtatga aatcggagcc tgtctcctta tagcgtcttt 3432301 caatgttgcg caatacgcct tcaaattgaa tttcaccttc gcggatttgt ccaaaatcat 3432361 tttcatatcg gaaataaatc aggtcatccc cgctgccgta cagcacttta tccagttgat 3432421 gcttcggcaa atctttgacc ggcacatcca tatcaatccc gtagtgggtg cagactgcct 3432481 caagcagctg aggataatat tgtgagctga tcggtgtcca aggggcgacc gcattctcct 3432541 tcaatgacaa atcttgattg gggatgacaa gatcggcatc cacttcaagc ttcattccga 3432601 gaccgtcaca cgtcggacac gccccgaacg gactgttaaa cgaaaacaga cgcggctcaa 3432661 gctcaccaat tgaaaatccg cagtgcggac aggcatgatg ctcgctgaac atcagctctt 3432721 cctcaccgat gacatcgatc ataacccgtc cttcacctaa acgaagcgcc gtttccaatg 3432781 aatctgacag ccgggctgcc acgccttctt tcacgacaat ccggtcaatg actacctcaa 3432841 tggaatgctt cttgttcttt tctaattcga tatcgtcgga aagctcagcc atctcgccgt 3432901 caattctgac tctgacatag ccttgtttcc taatctgttc aagcactttg acatgagcgc 3432961 cttttcggcc cgagacaatc ggcgccagca cctgaagctt cgtccgttcc gggtattcca 3433021 gaattctgtc caccatttgc tcgatggtct gggatgtaat ctcaattccg tgttccggac 3433081 aatgaggctt ccctactctc gcatataaaa gacgcagata atcataaatc tcagttaccg 3433141 taccgacagt agacctcgga ttgcggctcg ttgttttctg atcaatgctg atggcgggag 3433201 agagcccctc aattgcatcc acatccggct tatccatttg ccctaaaaac tggcgggcat 3433261 aggcagacag cgactcgaca taccgtctct gtccttcagc atatatcgtg tcaaaggcaa 3433321 gggaggattt acctgatccg gacaaacccg tgacaacgac aagctgatct ctcggaatcg 3433381 ttacatctat atttttcagg ttatgcgccc tggctccctt cacctctatc cgatccatag 3433441 ccatttgttc atcatccttc cgcttttagc tctaaaagta aatcgcgaag ctccgcggct 3433501 ctctcaaagt caagcgcctt ggcggcttcc ttcatttcat gctccatctg ttcaacgact 3433561 ttctggcgtt ctttcttcgt cattttcgac agcttcggcg cggcttttgt tttgtattcc 3433621 gctttatcct cagctgctac tgtggcacga atgacatcgc gaatttcttt atttatcgtt 3433681 ttcggcgtaa tgccgtgctc ttcgttaaac cgctcctgct gctcgcggcg gcgttttgtt 3433741 tcattaatcg caatttccat agacttcgtt attttatcgg cgtacataat gacgcggcct 3433801 tccgcatttc tcgctgcccg tccgatggtc tggatcagcg accgctccga acgaaggaaa 3433861 ccttccttat ccgcatccaa aatcgcaaca agggatactt cgggaatgtc caaaccttcc 3433921 ctcagcaggt tgatgccgac aagcacatcg tacttgccaa ggcgcaggtc gcggataatt 3433981 tcaatccgtt caagcgtctt gatctcagaa tgcagatagt ttactttaat gccgatttcc 3434041 tttaaataat cggtcagatc ctctgacatc ttcttcgtca aagttgtcac aagcacccgt 3434101 tcattccgct cgattcttgc ttgaatttcg ccgatcaagt cgtcaatctg accttcgatt 3434161 ggacggacgt caataagcgg gtcaagaagc cccgtcggac gaatgatctg ttcgaccatt 3434221 tcatctgtat gttcaatctc gtacggccct ggtgttgctg atacatacac gatattgtgc 3434281 atatgctttt caaattcctc aaaacgaagc ggacggttat caagcgctga tggaagccgg 3434341 aagccgtgat ccacgagcac ctgtttccgc gcctggtctc cgttaaacat gccgcgcacc 3434401 tgaggaattg tcacatgcga ctcatccacc acgatcataa aatcgtctgg gaaataatca 3434461 agaagcgtat acggcgttga acctggaggc cgcagagtca aatgtcttga atagttctcg 3434521 atgccggagc agaaacccat ttcacgcatc atttcaagat catatcttgt ccgctgctct 3434581 aaacgctgcg cttcaaggag ctttccgttt tcatgcatga ccttcagctg ctcctcaagc 3434641 tccttctcga tattttgaat cgccttctcc attttctcgg cccgcgttac gaagtgggat 3434701 gccgggaaaa tcgcaacatg atctcggtcg ccgagaattt ctcctgtcag cgcatctact 3434761 tcccgaatcc gttcgatttc gtcaccgaaa aattcaactc tgacacaatg ctcatcacgg 3434821 gatgccggaa agatttccac tacatccccg cgcacacgaa atgtaccgcg ctgaaagtcg 3434881 atatcgttgc gggcatattg gatgtctaca agttttctga gcagctcgtt gcgctcaatt 3434941 tccatttcag tccgcagtga cacgaccatt tcccggtatt cctcaggcga accgaggccg 3435001 tatatacaag acacactcgc aataataatg acatctctgc gctcaaacaa agctgatgtg 3435061 gcggagtgtc tcagtttatc aatttcatca ttaatactag cgtctttctc tataaatgta 3435121 tccgtttgag gcacatacgc ctccggctga taataatcat agtagctgac aaaatactcg 3435181 acagcattgt tcggaaaaaa ttccttgaac tcactgtaaa gctgtccagc aagggttttg 3435241 ttatgggcaa tcacgagagt cggcttattg acttctttaa tcaaattgga caccgtaaat 3435301 gttttcccag ttcctgttgc acccagcaga gtctgatgct tcttgccctc ctgaattcct 3435361 ttcacaagct tttcaatggc tttcggctga tctccctggg gctgatattt cgagactaac 3435421 tcaaagcgat ctttcacaaa aataagcctc cgtttcttta acgaaatctt cctatagata 3435481 tagtaacaca atggaaagca aaatcactaa aaatacgaac taaagttcgg tggtttttta 3435541 tttccagctg tttttgtgta taaaaaacct gcttttaaaa cgtaaaagca ggtattcagt 3435601 ctttatattc attatgtccg atttattctt cttttttctc tgcagctttt ttggccatat 3435661 acagtccgcc agccacaaga gacacaacat ccaatcctac aataaaatac gtttctgtat 3435721 agccttttaa ataagaggca aacagcaatg cagctgttaa agcgatcgcc acataatgat 3435781 taaaggtgac tctagtaaat agaacaacaa gcataaaagg gaaaaacaat gcaaaaacgg 3435841 cttttgtaat caacaaaaac cctcctcagg gattcttcat ctgatctgat tatagtaaaa 3435901 aatgaagaat cggacaatcg tgcattcgct ccctctactt acaccatacc ccttttcagc 3435961 caaaatcaat caccatattt gcattttggt gccggtcaaa acttattcca tggtgccgct 3436021 gttctaatca gcggcacttt ttttattaca tcatcaagtc cgccgccaga ttccgagaat 3436081 aaaagaaaat aggcatacag taccagtacg gccgcatttt tcaggataat ataaccaact 3436141 taactattca ttttatttag gactttctgc gtttgacagc attttcctga aaacctacaa 3436201 ttaaatgata gtgtttacta tcatttttta aacacaggct ccgcaataaa aagactagag 3436261 agaaaaacaa aatgaatgaa gaaaagaggg gtttcaaata tgtattctgt tttatttcgc 3436321 caggcagaag agtccagcca gctggctgga gcaaaaggaa tgaatttgat taaattgacc 3436381 aaacacggtc ttcctgttcc ggacgggttt attattcaaa cgaatgcgct cgcacgtttt 3436441 atggaggaca accagcttca agagactagt gaaaacgtcg aaggcgggat catttccgga 3436501 acattttcgg atgagctgaa agatgagctg actagttcct tttataagct tagagaatca 3436561 tatcgatccg tagccgtgcg ttcttcgtct gcttcggaag atttagaagg cgcctcattc 3436621 gcgggtcaat atgaaaccta cttaaatatc aaaacagagg aagagtttct ggctaaagtg 3436681 aaagaatgct gggcctcatt tttttctggg cgggtcagca gctataagaa aaaaatgaac 3436741 aatcaaatcg cagagccgtt aatgggaata gtcgttcagg ggctgatcga ttcagaaatg 3436801 tcaggtgtta tcttcagccg caaccctgtt acccatgatg atagagagct tttaatcagc 3436861 gccagctacg ggttgggtga agctgttgtt tcaggaaatg ttaccccaga cacgttcatt 3436921 gttaataaat cttcgtttga gattcagaaa gaaataggtg caaaggaaat ctacatggag 3436981 tctgcggcag aaggaattgc tgaaaaagaa acgagtgaag acatgcgcag ccgtttttgc 3437041 cttacagatg aacaagtgat tgaattggct gaaatcacaa aaaaaaccga agacctgtac 3437101 ggatatcctg ttgatataga atttggaatt gctgatcatc aaatatacct tctgcaagct 3437161 cgcccgatta caaccattga tcaggacaaa aaagcggcag aagaaaaacg cagcttcatg 3437221 attaccgaca ctgatatgaa tgatttctgg cttaacatgg agtctaatat tgaaggtccg 3437281 gtgagtccgt tattttcatc cttcatcgtg ccggcattgg aatatggctt gaagaagagc 3437341 atgcaaaagt ttccgattgg tgtagttgtt gatgaagtaa aactttatcg cggacatatt 3437401 tattccaaaa accaaggcgg acagcagcct ccttctgaag actgcggcaa agagcttttc 3437461 ccgattttat cggagcatat gtatgacatc atcaatcaca catacctccc tttttaccgg 3437521 acactggacc agctcgcaca aactgagcat accgcagaaa gcgcactgga agcttttcaa 3437581 aaactaaagg ccttttatct cacggcttat gaagagcact ttaatatcgt tttcccgcaa 3437641 atccttttaa caaacaaact gcaagcgatg tatcaggaca ttcaaggaga gtccgaaaac 3437701 gctcattttt acgagatgct gacaggaaaa atgaacaaat cactggaaac ggaccgttgc 3437761 ttatggctat tttctgtgga agttcaggag aacccgaacc ttctggccat ttttgaaaac 3437821 aacaagcctg aacagctcca ggagaaattg gaacaaacag atgagggaag acacttcctg 3437881 aagaacgtcc atgaattctt gcaagaatac ggatggagat ctgttaaaag tcatgatctg 3437941 attgaacaaa tctgggtgga aaatccgtat ttcgctctgg ccaatattca aaattatgtc 3438001 cgtaatggct atcattttga caatgaattt cagaaaacaa aagaaaaacg agagaaatta 3438061 tacaatgaat tcttggaaag catagaagat cccggtttac gcaccgaatt tgaccgctat 3438121 tatcaatgga cactgaactc tgcaaatata aaagatgatc accactttta tattgacgcc 3438181 atgctggatg ccaaggcgag aatctttctg ctgaagatag gtgaattgct ggcggaaaac 3438241 ggtgtcattc aagatcggga ggacctttgg ttcttatatg acgacgaagt ggaacaagcg 3438301 cttcttcacc ctgtatccct gcaagaaaag gctgaaaaac gcagacagat ttttcatgag 3438361 tatgagctgg cccaagcccc ggcctacctc ggcaccccga caaaagaaca gctcaaagca 3438421 gctgaagaaa ttgtcggcgc tgtgatagag gatgaaaaaa acacagagaa tcatattttt 3438481 ggcattgcgg catcaagcgg cattgcgaca ggtccggtga aaatcattcg ggacgccaat 3438541 gaattttctc aattcgcgcc tggagacgta ctcgtttgca agatgaccac accgctatgg 3438601 accagcctgt ttcaagacgc caaagcgatt attacagaca caggcggcat tttgtctcac 3438661 gctgcgatta ttgcccgtga atacggcatt ccagccgttc tcggcacacg cacggcaacc 3438721 gaaagactgc gagacggtga catcatcact gttgacggaa gcagcggcaa aatcacagtt 3438781 gtcagccggt cctgatgcgt ccccctcttt cttatacaag cggggcgggt gtatacttgt 3438841 cctgccagta tattcgtgag gtgaaacgta ttgagaccga caaacaagag aatccttgat 3438901 gctgccatgc agctgctcgt caaaaaagga tatcgcgcaa cgactacaaa agaaattgca 3438961 gaaaaagcaa atgtaagtga agcgacgatt ttcaggaact ttaaaaacaa acaaggacta 3439021 gttgaggctt tgctttctca gcattcttca aacagaggca gcattttgga acaaacagaa 3439081 ggggatttgt acaaagacct gcttcatatc ggaacctgtc tcttggagga gctcgaacat 3439141 agaaaagata tcattaaaat cagctttcgt gaaccggcca tgtttcagga tgtcattaac 3439201 cacgtcactg aatatcccca atctatgaaa cagctattgg ttgattatct caaaacgatg 3439261 ggtgagaaag gggttattca gacaggaaat gaagcggaac atgccgacgt gttcatgtcg 3439321 attatcttcg gttatttcat tcaccgtctc cacttaggag accgggtcat atcaatgccc 3439381 caggaaaaaa tgctggagca tagcacagct ctatttgtca aaggaatttc tgctgattaa 3439441 ctccttggca taataaaaag gaggatccca atgagctcaa gaaaagaatg ggcgctgatc 3439501 gtctcgctat tattgggggc cattctggtt cccattaact caacgatgat cgcggtcgcg 3439561 ctctcatcta tttcccatac gtataacgag tccatcgcaa gcatcacttg ggtggttacc 3439621 gtttatttaa tcgtgatggc agtcacacag ccgattgcag gaaagctcgg tgacatgtac 3439681 ggcaataaaa caatgtactt atggggagtc ggcctttttc taatcgcatc tctaggctgc 3439741 gccctttcac cgagtctgct cctgttaatt gtctttcggg cattgcaggc tgtcggcggg 3439801 gcattgctta cgccaaacag cattgccatt atccggcatg ttgtttctga aaaacgccta 3439861 ccgaaagtgt ttggattttt cggactgggc gcgggacttg gtgcagcact cgggcctttt 3439921 atcggctcta tactgattga cagcttcagc tggcattcga ttttttgggt caacatcccg 3439981 ttcctcgcca ttgctttatt tacggcatta acgatgtttc ctcaatataa agaaaataaa 3440041 tctgacgcgc cgctggatat catcggctct ctcttgcttg caggcagcat cgtttccatt 3440101 atcctgctga cgaaaaatga ggctccatgg ggatatactg tatacagtgt attgatactt 3440161 ctttttgttc cgcttttttt cagaagagaa aaacgtaccc agcaccccat cattgacttt 3440221 gcactgttta aaagctcaac ctttacaaat gcgaatctat cagtcttgtt aagcaatttg 3440281 atgatgtatg ccgtcttatt gattatgccg ttatttatga cgaaccaatt tgggcttaat 3440341 acatctaaca gcgggatggc gctttctgta ttttcgatct tcatgtcagc cagcaactgg 3440401 gtgggcgcgc agctccatca caaatgggga gccaaaaaaa tcatttttct ttcatttgcc 3440461 atgatggctg gtgcgaatct attatttttg ctgttaagca gctcgcattc tgtcttgttc 3440521 ctcatgctct ctcttatcct tggcgggctc gcttccggag tcggtctgac cagcatgcag 3440581 gtttcatccc ttgccacagt agaccccggt atgtcaggag tggcatctgg gattttctcg 3440641 accttccgtt atttcggaag catcatttca tcagccttaa ttggcctgat ttcgggatat 3440701 cacaccctat ttatgattct ctttgctgta tccatcatcg gcgtttttgt ttcattgggc 3440761 atcaaatctg atgaaacggc acggatagaa aaaaactcag cgtaacacaa aacagcccgg 3440821 catcgcatca tcctgcggtg ccgggctgcc ttttatgatc ccgaagcgac tgcttcgtct 3440881 tcacggtcat cctttacgaa gaggatgccc aattcatgat gttctccttc ataagaagct 3440941 cgctggtcaa aacgaatttc tccattcaaa ccgataattt caagctttac atatgcacgg 3441001 ttatgctgaa gcgcttcata gaaatcagaa acgttcttaa ccggtatgcc attgactttc 3441061 gttatgattt ccccgatttt caattccaga tcctcagccg gcgtattggg gataatccca 3441121 agcaccatta agccctgatc ccttttcgag aaataaaacg gagccgcgtt atcattcact 3441181 ctttgcttta tggacagaaa aatacgccct aacaaagcgg tacagaccgc tgcacccgca 3441241 agcggcgtcc acagtaagct cgctgcaccg agaactgcga cggcaagacc gagaatacaa 3441301 acgcgtttcg ctgtgatcct tatactcgtt tcaggcagcg atccctgtac cctttgtcca 3441361 aatccgacaa agtaaggaat ccatagaaaa tggaatgagc cgccgggaac cgtaaacacg 3441421 ggccaccagc taaggtgcga ttctaaacca ttaccgggca cgagaaggaa cagcggcaaa 3441481 agccaaaccc ggtttgccag ctgctgtccg atcggcaaac cgcggctgct tacgacaagt 3441541 gccggtgatg ttctcacatg cgcagaacga taagcaaccg ctccttcagt gataatcagc 3441601 aaacctagaa acacagccac agccggccaa acaactgcaa atccttgcgg aaatctctcc 3441661 agaaagggct ccgcctgata tatttgcagt ccaaaaccta tcagcatact cacactgacg 3441721 atatatgcag cagacatcca gtttgcgcga agagtgaacg ctgccgctgc agtgataacg 3441781 gcaataatcg caagtaaacc gagaggaatc gatattccga gtccacctaa aataactgac 3441841 aaaagaagac ctggaatcag tccctttgta tatgtaaatt tcagatcatc ataaatatct 3441901 gctattcttg tatgaaaggt ttttcgttcc cgtttgattc ttacatagcc gaaagccaag 3441961 gttatgatga taaaaaacca gaaaagcggg tgtaagaaga acaagcccgc gctttttaac 3442021 agttcaattc cccattgaac agacactatc tctcaccgcc tcaagccaaa catgttactc 3442081 atattctatc aaatattaaa tggcttggat atcctcagga gagtttatct ctcttgcgtc 3442141 atccacagcg tgacattcga tagtgaaaaa tcctttaaat agtggtttac atccacatcc 3442201 aataacccgc tgattagatg catcgacctt tttatatctg tcagattaat tcctaatcgc 3442261 ttatggtttt tcattaagta gttaaaataa tgtttggcgc attcctcatt aatgtcattt 3442321 actgattcga cattggtgta attgaccaaa tatctgctga acagcataag aagacttagt 3442381 gcttttgtag ctgaaaatgt tacgtcttgt gttctgtctt ttaattgttc cactaattca 3442441 taatattttt ttttcacgca caatacttgc cctcttcaat tgtgaacccc cattttcttt 3442501 atacagataa gcacgggcca gtataagcag cagtactgga gtgctaacaa gcattctcgc 3442561 taacgttact ctttaaatac ctgtcgttca gctgccatta acctgattac tgttcttttt 3442621 agaaccttct tatattgtat gaagtaaaca aagactaggc aacttgcaaa agtttcattt 3442681 taaatgcata ttaactcgtt agaaagtctc tctcatatat tgatatcggg taataacagt 3442741 cctttataaa tgtttatttg tgaaaatttt tttaatttct tgtcaaaaac tcatttttta 3442801 tgtgacttat gatccataat ctctttaagc acaaagaaac aggagatgaa ataccatctc 3442861 ctttaattga caaataatga tttcaatgct gtttgaagct gcaaatcatt tttttcatct 3442921 gattttttct tttctatctg ctgatttaat gtctctgcag tgcgagtgtc gatcacaccg 3442981 gttttattca gcttgttttg atcctgaaaa gccataaccg cttttttcat gtctttgctg 3443041 aaatagccat cctcacgtcc cggatcaaag ctgagacctt ttaacaatac ctgcgcatgc 3443101 ttgacgtctt cattgttcat gtccacttta agcggctctt tcagctgtaa gggcccggcg 3443161 gaaaaataat cgggctgctt aatcgcaatg gtcggttcaa ttcctttctt atgaatccag 3443221 tttccatttg gcgtcagcca cttgtaaagc gttaatttga tgttgctgcc gtcccccatt 3443281 ggcacagcct gttgaaccgt tccctttcca aaagacgtat cgcctacaac atcataatgg 3443341 ccagcttcct ttaatgcgcc ggcaagaatt tctgatgcag aggcacttcc tttatccgta 3443401 atcacattga cagggtacgc ttttttatgg gtcaatgttg aaaaataacg ttttttatct 3443461 ccattgcgtt cagcaatctg aatatacggc tgatcctttg taacgaaatg cttaagaatt 3443521 tcttccacac tttgaagata tccacccggg ttgccgcgta catcaatgac aagtccttct 3443581 atttcttttt tctcaagctc cctcagcgct tttgcaaaat cctctgcggt gtgctcagaa 3443641 aaagtagaga tggcaatata tccgacagaa tgcccctgta cttttttctc tgatgcaaaa 3443701 accgtttcga gcggaatctc agctctcttg atccggaatg acaactgctt cttcgttcca 3443761 ggccgctgaa tcttcattga aacgctggac cctttttttc ctcttatttt taacacagcg 3443821 tggtttaaat ccttgccggc catcgattct ccattgatgc tgataatttc atcattaggc 3443881 ttcaacccgg ctttttccgc tggcgatttc ttgaatggag aaacaataat aattttgccg 3443941 tcttccattc caacctcagc cccgatgcct tcaaatgagg aatcaagaga atcagaaaat 3444001 tgcttagctg tctgcttgtc catgtaaaca gaataaggat catttagcgt agacagcatt 3444061 ccctggatgg ctccctcgag cagcttttct ctatctactt tttctacgta ctcattcgaa 3444121 attaactcat acgctttttc gattttgtcc atagctttat cccgttcaga gtcagcttgt 3444181 gccgtcgcgg gaactgctgc agtctggggc ttatccatct caagcaggtt gattcccgca 3444241 tatacaccgg cgcctccgaa cagcatgctc cctgctgcta tcacagccat tattttttga 3444301 ttcatccttt actcctcctg tatgccagac tgtctttacc aaaacctaga gatagtatat 3444361 gtaaaggatg gagatttcat gtaatcatag aagaaaaaga aggcaaatga aaagccgtcc 3444421 cgaaaacgga acggcttttt cactttatac tcgcagaaac ttgcggatgg aagtcagact 3444481 tccccatact ccaattactg cgccgattgc aatcagcact agcgaaactt ggaatacaaa 3444541 tggattataa ggaagaagag agacaaatga tccttgaacc tttggaacga cccatccgat 3444601 gacgtattgg taagtgctca gcaccagtgc aatcggaatc acagaaccga atacgcctag 3444661 cagcaatcct tcaaggaaaa acggccagcg gataaaccag tttgtcgcgc cgacaagctt 3444721 catgatttca atttcttttc ttcttgcgaa aattgtaatt ttaatggtgt tggaaattaa 3444781 gaacatcgcc gtaaatacca ggccgataat taacgcgatt ccgatgttgc gggaaacgcc 3444841 gaccacttta aacaaacggc tgacctcttc ttttccataa gtgactttat aaacatgatc 3444901 cattttttcg atctttttcg ccacgttcgg cgtatcatgc ggatctgtcg ttttgacgac 3444961 aaacgcatca ttaagcgggt tttcctgatc cttcattgtc agggattttc cgctgtcacc 3445021 aaaactgtca accagctggt caagctcttt ttctttagat gaaaaagtga cactctgaat 3445081 gcccttcagt tccttaatat cgttctgaag cttgtcctgt gccttctgat ctgcagtcag 3445141 atcaatcagc actttgattt cgacttgttt ttctgcattc gtggccatgt tattcaaatt 3445201 cagcataatc actaaaaaca cgccgactaa aatcagcgta acggttacag cactaatgga 3445261 tgcaaatgtc atccatgtgt ttctcccgag agatttaaaa ctctcacgca agtggcgccc 3445321 gagaatttta atcatatgaa ccatactccc ctcttgactc atcacgcaca atgataccat 3445381 cttcgattgc aatgacacgt ttcttcatgg tgtttacgat ttctttatta tgtgtcgcca 3445441 tcacgactgt tgtcccgcgg ttgttaattt cctccagcgt cttcatgact tcccaggacg 3445501 tatccggatc aaggtttcct gtcggttcat cagcaatgac aacatcaggg ttgttcacaa 3445561 ttgatctggc aatagataca cgctgctgct ccccgcctga aagctggtca ggaaattgtc 3445621 gcgctttatg cttcagctgc acgagatcaa gcacttcaag cacccgtttc ttaatgacag 3445681 acggctgttc tccaatcact tcaagggcaa atgccacatt ttcaaaaaca gtaagtttcg 3445741 gaagaagctt gaaatcctga aagacaacac ctattttgcg gcgcacgaaa ggaatctctt 3445801 tttctttaat tgtcgcgaga tctttatgat tgattaaaat ttgtcctttt gtcggttttt 3445861 cttctctgta aatcatttta ataaaagtag atttacctgc tccgctcgga ccaacaacat 3445921 acacaaactc gccgggatga atggtaacag aaatcccatt gagtgctttt acgccgttcg 3445981 gataggcttt atatacttcc ttcatctcta tcatgaaatc acctaatctt ttatatcatt 3446041 ttatctatca cacggtcata ctcttcgaat gcattcgaca atttatgacc cattcatttg 3446101 taaaaagatg aaaaatctga aagttccctt tttcaataca cttcattata cgtcaaattt 3446161 agacataata ctattacagt ttcttttcat tcatattgtc aaggcataaa aacatccttg 3446221 ccagcactcg gcaaggatgt ttttatctta ctttttttct gacagccatt tggcaataac 3446281 agcggcttcg ttatcatcta caagcccctt tggcatattg ccgcggccgt ttttaataat 3446341 gctttcaatt ttgtgttcat cgtatttgcc tccgacctct tggagattag gccctgacac 3446401 accttctaaa tccttgccgt ggcagcctac gcagctttgc tgatataatt cttccccttc 3446461 agatgcagtg gcttccgtct tgctgccagt gtctgtcttc tcttcttttg catcgtttga 3446521 tccgcaggca gccaacagaa cagaaagcgc aaatccaatc attagtatcg ataactttga 3446581 tttcatgttg agaagcacaa ctcctttacg atctcttcca tattataacc tcgtttaagc 3446641 gcgtttgaaa ccctcgccca gcacctcgct cgcgtctgct acaattacaa aagctgactc 3446701 atcaatctgt ttgacgattt gtttcaattt ggtgaattca gtttgcccaa ccacgcacat 3446761 taaaatcgga cggtcatcgt cagtatatcc gccgactgca gaaatttttg tcacgcctct 3446821 gtcaatcttc tgtaagacag cctccttgac agcctgctcc tgctttgtaa tgatgagcgc 3446881 catttttgaa cgattaaagc cgacttgcac aacatcaatg gttttgctgg acacatagac 3446941 gccaagcatg gcatataagc cttgctcaat attaaataca atcatagccg taacaacgat 3447001 cattccgtca atgatggcga gacacttccc caatgacaga ccggagtact tatgaatgat 3447061 ctgtgcagcc aaggctgtac ctcccgtcga acctttccct aagtacacaa taccaattcc 3447121 gatacctatc ccgacaccgc caaaaatcgc cgccaggagt tcatgatgag tggcgggctg 3447181 aatatccctt gtcagaaaca ctactagcgg caaaaacaca gaacctgcaa gcgtctttag 3447241 tccaaatttc ccgccgagca aaatgacgcc agcaataaat aaagggatat taataatcca 3447301 ctgtacatac gctgcttcaa aaccatatga ttgtaaaatc gtactgatcc cgctgacccc 3447361 gccggcggca atcttattcg gaagcaaaaa tacattaaag gacacggccg taatcgctgc 3447421 tcctatcaat atgtatacat aatcccgcaa aatccacaat gttttattcc gtacgtccat 3447481 catatatcct ccgtttcttc caatgctctc cgatagcatt ttaatccttc cctgattaga 3447541 tgtaaataac acccaaatac agtggtaata tgctaaagca gcagtgaaat caaggatata 3447601 agaaataaaa aaacacaccc gtatgcatca ggtgtgtttt tcagcttatg aaagcttaga 3447661 acgcaggtag gcatcaataa acgtatcaat gtcaccatcc attacagctt gaacgttccc 3447721 catttctgta ttggtccgat ggtcttttac catggaatac ggatggaata cataagaacg 3447781 gatttggctg ccccagccga tttctttttg ttcaccgcga atttcatcca gctctgcctg 3447841 ctgctcttca attctgcgct gatacagctt ggccttcagc attttcatgg ctctttcacg 3447901 gtttttaatt tgtgagcgct ccgtttggca tgtcacaact acgttcgtcg gcaagtgagt 3447961 aatccgaacg gctgaatccg tcgtattgac gtgctgtccg cccgcgccgc ttgcacggta 3448021 cgtgtcaact ttaatatcct ccgtacgaat atcaatatca atttcatcgt taaattcagg 3448081 catgacttca catgaaacga aagatgtgtg gcggcggcct gatgaatcaa atggtgagat 3448141 ccgcacaaga cgatgaacac ctttttctgc tttgagatac ccgtaagcgt tgtgtccttt 3448201 gatgagcaat gtcactgact tgattcccgc ctcgtcacct ggaaggtaat cgagagtctc 3448261 tactttaaag ccgcggcgct ctccccatct tgtatacatt ctaagaagca tagagcccca 3448321 gtcctgtgac tctgtaccgc cagcaccagg gtgcagttct aaaatcgcgt tatttttatc 3448381 atacggctcg ctgagaagaa gctgaagctc aaactcattg aactcttttg ttaatgactt 3448441 tagttctttt tcaagctcaa gctggagatc agtgtccggc tcttctttca aaagatcatg 3448501 agtcatttgt aattcttcgt gggattcatt caatttttta tacgaattga cataatcctt 3448561 taaaccgttt gcttcattta taaccgtttg agctttttgc tgatcattcc agaattccgg 3448621 atcagccatt tgttcatcta gctcagcaat gcgggcctcc tttgattcga ggtcaaagag 3448681 accccctaaa gtccgctaaa cgagaagcca tattttcgag ctctgctcta atttctgata 3448741 attccatttc attcacctca ttaaaagatc cgcaggcgcc tgcaggcgcc gcggtcagta 3448801 aacttgccgg ggcgaactat tcagtacggc cgcagcaatt tttatatttt ttcccgcttc 3448861 cgcagtggca tggggcattt cgtccgatat caaccacttt gcgaaccggt gctttctttg 3448921 cttttttgtt atcgtcgcct tcttgcggct gatgagctgt tgtttgacct tgtacaacct 3448981 cttcacgctc cagattgttt tcaatctcag ctttcatcac aaattttgcg acttcgtcct 3449041 caattgattc aatcatatgc tcaaacatcg caaaaccttc catttgatac tcacgaagcg 3449101 ggttcgtctg cgcgtaagca cgaaggtgaa tcccttggcg gagctgatcc atcgcatcaa 3449161 tatgatccat ccatttagaa tcaacggcac gaagaacgat aactttttcg aattcgcgca 3449221 tttgctcttt gccgaattgc tcttccttct cattatattt tgtgatgatg cgatccataa 3449281 tgagctcaag catttcatcc ggttctttgc cgaagatatc gctcttctca agtgcacctt 3449341 catcaagata agttgtgttg ataagatcaa ctagaccgtc aagcttccac tcctcaggaa 3449401 gctcttctct tggcgtatag gctgcaattg cgcgttcgag agaagacttg atcatatttt 3449461 caacgatttc acgcaggttt tcagagtcaa tgacttcaaa gcgctgctta taaatgacct 3449521 cacgctgctg gcggagaaca tcatcatatt gcagaagctg tttacgcgaa tcgaagttat 3449581 tgccttcgac gcgtttttga gacgattcaa ccgcgcgaga taccattttg ctttggattg 3449641 gagtagagtc gtccatgccg aagcggtcaa gcatcgccat tgtccgctca gctccgaatc 3449701 tgcgcatcaa ttcatcttcc atagaaagat aaaattgagt aatccccggg tctccctgac 3449761 gtccggaacg acctcgaagc tgattgtcaa tccggcgtga ttcatgtcgt tctgttccga 3449821 ctacagcgag cccgccaagc tcttttacac cttcgccaag cttaatgtcc gttccgcgcc 3449881 ccgccatgtt agtcgcaatc gtaactgcgc ctttttggcc ggcctcttca atgatctgcg 3449941 cttcacgttc atggtttttg gcatttaaca cttgatgcgg aattcctttg tttttaagca 3450001 gcttagaaat caattcagat gtttcaacgg caaccgtacc gactagaaca ggctgtcccg 3450061 tcatgtaacg ctgtgcgaca tcctccgcaa ctgccttaaa ctttccttcc atcgtgcggt 3450121 aaattaaatc cgggcggtca tcacggacaa caggcctgtt ggtagggatc gtgacaacct 3450181 gcatgttgta gatgttgcgg aattcttctt cctctgtctt agctgtaccc gtcataccgg 3450241 caagtttttc gtacattcgg aagtagtttt ggaacgtaat cgtcgccaag gtcatgcttt 3450301 cgttttgaat ctcaagccct tcctttgctt caatcgcttg gtgaagcccc tcactgtagc 3450361 ggcggccttt catcagacgt cccgtgaagg aatcaacaat aacaacctgt ccgtcttcca 3450421 ctacatagtc aacgtccttt tgcatcgcaa cgtgagcttt taaggcctgg ttgatatggt 3450481 ggttgagcgc gacatgcttc acatcaaaga ggttatcgat gccgaatgct ttttccgcct 3450541 tcgtcattcc ttcttcagta agctgtacag cttttgtttt gatatcgtac gtgtaatcct 3450601 tctccgcttt taacgtgcgg acaaaagcat ttgcctgtac gtacagctta gtggattttg 3450661 cagcttgtcc agaaatgata agcggtgttc ttgcttcatc aattaaaata gagtcaactt 3450721 catctattac cgcaaaatga agcgggcgct gaaccatctg ctctttataa agaaccatat 3450781 tgtcacgcaa atagtcgaag ccaagctcgt tgtttgtgga gtaagtaata tcagcggcat 3450841 aagcttcccg tttttcgtct tttgacattg agtttaaatt caaaccgaca gtcaaaccga 3450901 gaaactcgaa aattttcccc atttgctcag cgtcacggct tgccaagtat tcgttgacag 3450961 tcacgacgtg tacgccttta ccggttaacg catttaaata aacaggcagg gtagacgtta 3451021 atgttttccc ttcccctgtt ttcatttccg ctatatttcc gtcatgaagc gccacgcccc 3451081 ccatgagctg gactttaaac ggaaacatgc ctgttacgcg gcgtgaagct tctcgaacaa 3451141 cagcgaaagc ttcaacaaga agatcatccg ttgtcgcccc tttttcaaga cgctctttaa 3451201 attcaattgt tttatgtttc aatgcgtcgt cagagagatt ttcatagtct ccgcgaatcg 3451261 catcaatatc gttagcaatt ttttcgtatc tattcagcgt acgttttgtt ggatcaaaca 3451321 ttttatttaa aattccaagc atttataacg ctcctctatc atcacacgcc tattttagag 3451381 gcatgtataa ataatttact agtccatgta tacctctcat tatcatatca taccttttgt 3451441 tatttccaaa gaatttgcaa ataagaaaaa caaaaacctt ccgcggacat cacggaaggc 3451501 ttctcttcat tattcagtcg gttcaattaa gccatatttc ccgtcatttc tgcggtacac 3451561 gacatttgta aggtttgttt ccgcatttgt gaaaacaaag aaattatggc cgagcatatt 3451621 catttgcaag atcgcttctt cactatccat cggctttaaa ttaaagcgtt tctgacggac 3451681 gatgtccaag ctctcctcct cttctatgtc atcctgaacc gcaatatctg tatcagagcc 3451741 aagaccgttt gccaataaat attttggaga gccctgctca cggaatttac ggtttacttt 3451801 cgttttatgc ttacggattt gacgttccag tttgtttgtt gcgagatcaa ttgcgttgta 3451861 catatcctcg ttatgcacct cggaccgaag cgccagatct gtcatcggaa tcgtaacctc 3451921 aaccttagac tccttgtcat tgtaaaactt caagttgacg ttcacatcag catccacgct 3451981 atggtcaaaa tagcgctcca gcttgccgat cttcctctcg acatgatcct ttaacgcggg 3452041 tgtcacttca atattttctc ctctgatgtt atagttcatc aaagaacgcc tcccttttat 3452101 taaggatatg tatctatttc tcttttaccc tttacaattc ctgctgaaac ataaatcttt 3452161 tgtgaaaatt cagtgaactt tgtcgaattt tgtttgtatt tgctctgtta ttggcggttc 3452221 ggaggtatat gtatatgctg attgaacgaa acaaatacct cacacacgcc taattgatta 3452281 aaaagggttc catacattga tgaatagaca gcatccattt tctataatga atcagaaaat 3452341 gttcctttaa atactcacag aactcatgag agggaaaaga gaaagagacc aattgatcaa 3452401 actccgcaaa aatttggtca aatgctttca cacaaatttc agcacaccgc gaatccataa 3452461 tgaagagaag tgttgaatgt gttgaatcca aataaaaaaa ggcttggatc agatcttggt 3452521 agatccgatc cccttctgtt tttgataaat tctcttcagc ctctatcaaa taacacaacc 3452581 cctcttcgat ggtaaaaaga agatgataat aagctgataa aagcgtataa tcttcaatgc 3452641 tcttcaaggc actcacctat ttacgcttgt cataatatgt gccgtcaatc gtaatgttgt 3452701 tataagggtt taaatacgtc gtatgcatca cacgttttct tttcatctgc tgaagttctg 3452761 ttgcgattga ctgcttcagt ctttccattt ccttcacaat cagctgatcc catgtcaaaa 3452821 taagtttcat ctgctttcgc tcttcttctg aaagcggcag agatatctcc tgaatcagtt 3452881 cagaccgtgt agccacaaag tcttcaattt gctttaaaag ttcatcgctt tccggcgtat 3452941 tttgtatgtg tgacagcata ctcttcgtct cagtgtatag ttgatctata ttattcatgc 3453001 gatcccgcct gatccgtgcc ggtccttccg ctcactttga atggcttgtt tccaagcatc 3453061 gcgaaaatct gttacataac cttcaacctc agccagcatg cccgtatcat ttttgatatt 3453121 tgcctgtacc aatctgcgat acatataatc gtacatcgca cccatagaag cggaaagctc 3453181 tatgttacgg ttaagtgtaa aatttaattc ctgaataata ttttgcgctt taatcagatt 3453241 ttcattttta cgttccatat catcattctc aatggcctga gcggcaagtc ttataaattt 3453301 caaacagcca ttatacagca taagcgtcag ctccccgggt gtagccgtat tcactgaatt 3453361 ttgctgatag gctgtatatg gattttggat cgccatgtgt catcctccaa attacattta 3453421 ttgtacaaga agctgtgata aataggacgc ttgttcgttc attttttgaa tcgcagaatc 3453481 cattgcactg aattttgaat aatagcggtt ttctatggta ttcaatctgt cctgcatatc 3453541 agttatttca gtacttatcg agtttaaatt ttttccaatg gaatagctac tagctcccat 3453601 tgtcgagttc ccagctttag cttcaatact tttcacagta cttctaagtg tattagtaat 3453661 ccgcttcata atacctttat cgctatagtt actatcattt gttccacttg taaaaagatt 3453721 agcaactcct tgaggatctt ctgctatttt tgctttcaat ttctcttcgt taatctctaa 3453781 gtgccctcgc agttggtaag cacttgaagt tgtgatgcca aattcagtta attgataggt 3453841 tttcccatcc gcattcactt gagtataaaa gtcagtccgc atttggttcg tgccagtgct 3453901 gatgcttgaa tcgtttctca gcaatccgct tttcgccttc tcctcccaga gctctacctc 3453961 tttatcggac atggcttctt tttgttcact cgtgagtggc gtatagtctc ggtatttttc 3454021 ttctttcagc ttttcattca ggctgtcaac cagttcattg tatttatcta caaactcttt 3454081 gatttggtta taaatcccat caacatcagt agaaacagat gtggtaacag ggcctgtggc 3454141 tgcagttgta tttttaatcg aataagtaac accattcacc gtgaaattgt ttgtcagctt 3454201 ctccatttca aagccgttga ttgtgacttt ggcatttgtg ccttctttgt aagcagtaag 3454261 cttattatca gcatccaaag aaaaaccaag ctgaccggac ataaagtcag ctgtagcaga 3454321 gtctgctgcc tgtatgcttc ctcctgcacc tgttgcttta gaagaaaacg caatcgtttc 3454381 tacgtactct gtaccattcc aaattttatc tttaaatgct gatactccta gatctgagct 3454441 gttaagttta gaaatcacat tatcaatcgt atcggcactc gtcacactaa tgttcactgt 3454501 ttttgctgtt gtttcgccag gcgcaacaac gttaaatgcc aaattgtaat cgccttgtgt 3454561 gtatcccgta taattgtttg ccttatacgt tgctgcagtt gccaagctcg ccacttcaac 3454621 agtagacgaa gaatttggcg cacttacgct tcctgtagca gttaacacag actcattaga 3454681 gcttgtcaca gttttgctct gatacgtgct cggatatgtc aacgtatttt tagacatata 3454741 atcttgcaat tcttttattt ttgagtttac ttcacgatag ctgtcacgct gccattcaag 3454801 agtctgcttt ttttgtgtca gcttatcaag cggcgctctt tctgtctgca tcagctttga 3454861 tacgatatca tctatatcca ttcctgacgc cagacctgtt attcttgtga ccatctcaaa 3454921 ccactcctat tctacttttt ttcatctaca aataacccaa gaaattcagt catagccgca 3454981 taaaaatcaa gccaccgttt tggtggaatt tcgcggatca cttcatttgt agagtcctct 3455041 attaccttta catagtattc atttaacttg tcatgaagct cgaacttcag atgaacttgc 3455101 gaaggttcca aaagcttgtt catttccccc accatttcag caagattggt atatgaaact 3455161 tgatgaacag gaacctcgtt atcattatct ttctgattat gtatttgagt atcataacga 3455221 tcccaaacag gttgtaacgt agtgagcctt tcaatgttca attgatcatc ccctatgccc 3455281 caatctatcg tttatatcga ctaagtcgag ataagattac acatattttt ggaaaaaaat 3455341 cttctgtttt agatttcttg tatggaaata catttataaa aagttagtgg agaatccggt 3455401 tattatatca tgagttagtg acaggatgag gaatgattag gagatagaaa tttaaattaa 3455461 aagaccctgg caacgccaag gtctttttta aaattaacgt aataattgaa gtacgttttg 3455521 cggctgttgg tttgcttgag caagcatagc ttgagaagcc tgagaaagaa tgttgttctt 3455581 tgtgaattcg ctcatctctt tagccatgtc aacgtcacgg atacgagact cagcagctgt 3455641 caagttttca ccagaagcgc ttaagttgtt aattgtgtgc tctagacgat tttgtaccgc 3455701 accaagctta gcacgttgag aagaaacttg gttgatcgct tcatcaacaa ctttcaattg 3455761 agcatcgaaa ccgatatcag cagtatctgc tgcattatct gcgaattttg ttacgtcaag 3455821 atcattaact gaatgaagag ctgcaattga accatcagct tctttaattc caagagcgtc 3455881 agcacccata tcctcaatat ttacagagat ttgctgtgta gcatttgctc cgatttggaa 3455941 taccaagttc ttttgatttg caggagtagc tgtgtcaact ttgtaagtgc catcgagcaa 3456001 tttcttacca ttgaattctg tacgatttga aataccatcg atttcatctg ttaaagctga 3456061 aatttcatct tgaatagatt gcaaatcagt tgctttgtcc tgagttccag tgtttccagc 3456121 ttgaacaact agctcacgaa cacgttgaag gatcgcatga gtttcagtta atgcaccctc 3456181 agctgtttgg ataagagaga ttccgtcttg agagttttta gaagccattt caagacctct 3456241 gatttgtcct ctcatttttt cagagatcgc aagacctgct gcgtcatctc ccgcacggtt 3456301 gatgcgaaga cctgaagaaa gtttctccat gttcttttgg ctcgcactgt tgtttgaaga 3456361 caaacggttc agtgtgttaa gcgctgcaat attgtggtta attctcattg ttttgttcct 3456421 ccctgaatat gttgttaagg cacgtccttg tgcccttatt ttgtaactgg ctgagtcttt 3456481 tgcgcctcct cccggctaca tcattaatat cggattgtct ctgattttgt taatacaaaa 3456541 ataaaaaaat cctcactttt tttgtgagga taatgcggag atcacatcgc tggataacgc 3456601 tgctgcacgg ttattttctt cctgaatggt caagtaaatt tctttcctgt gaatatcaat 3456661 atgctttggg gcgtcaattc caagcttcac ttgatcccct tcaaccgcaa tcacttttac 3456721 ttcaatatca gcacctattt gaatcgcttc gtttattttc cgcgataaaa ctagcatgat 3456781 tctcctccaa tcggatgctt tgtcgtatat gaggagtcgt gtaaaacgac ttgcttagcc 3456841 atcatgttct tgcgattcac aataatggga gccaataaat tcgcagtaga cttttcaaat 3456901 ggctctgcca tagtcaatat tgtcatgact tctacgtctt gaatattatc gatatccaaa 3456961 agttcagcag ttgattcatc aagatcaaat tcataattct taaaaaagat aaacggactt 3457021 acgacgataa acgcaagatt ttctgaagtg acggactgca gtgccacgaa tggagagtct 3457081 tctgaaagcg gaagtatgac gaactgtttt tcttctaaaa agcctggaat cccgctttca 3457141 aaaagaatga tttgttcttc ttttatgttc atttggccat ggtacttcgt atgaatgatc 3457201 attgttcacg atccttttct ttttactttt cgggtgattc tttcgggtat tctacatcta 3457261 tatttaaatc agggtattga agcatgtcaa ccttaacatt tcctggcgta tattcaacaa 3457321 ttggcttatg cggctcagcc tgaataacag gctttcgcgg cgtaatctgc acatcaagct 3457381 gtgacggagt atattgtatt ttcaccctcg aaagagaagg agcataattt tcgcctaatt 3457441 gaatttggtg catttcagag ttcctccttg cttgtgaagc gattgggttc cccttatttt 3457501 caatcttcat aagctcgtcg ccttcttctg cagtgcgtgc tattccctcc attacatcct 3457561 catgcccttg ttgggcggct tcttcaattc tcttgaaaac atgctttctg tctaattctt 3457621 cccatgcttg tgtctggtca atcgtgagtt ttccaggtgt caccgatatt tccatttccg 3457681 cactcggctg ttcgatctct agatcagctt gaggctgctc catttttaag ctggcaggcg 3457741 tcgttgttaa accaattttt ccttgaacac tatgcataat caatctggga atctgcatca 3457801 ctctacctcc tgaactataa aaaaagcgaa ctcctaagag ccgcttactt taaaaagtca 3457861 atcaatgtag gctgaacaat ttgcgcatta acggccagag tagccctgtg cacactttgc 3457921 tgcgcaataa attcagttat tacttcttcc agttctacat cttcattgtc tgataacact 3457981 ttggtagctg tttcttcttg cgctgacagt cttgtattaa ccagttcaag acgattatat 3458041 ctcgctccaa gatcagatcg ttcagcgctc atgccgtcag aaaaatgatc aatatcattt 3458101 aaaacactgt ccatgccatc tagcgaacca gaatttagtg ctttctcaaa agaatcaagc 3458161 atttcaaata cattctgccc gctttcagaa gtgcctccaa aagctgactt tggatctgaa 3458221 ttcactttca atgacatatt atttgatata ttgactacga catcagctgt atcagaaatt 3458281 gtataagttc cgtctccgtt atctgtaacc ggaggcttat ctgaatttgt gccattaaag 3458341 atatatctgc cgttcacttg tgtattcgca atatttaaaa gctgttcctt taactgcttt 3458401 acctctacgc caatcgcttg ccgctccggc tcgccgtttg tatcattttg agcttcaacc 3458461 gctaattctc tgacctttga caagatgtca attccttctg taatgtttgt ttctgtgttt 3458521 tcgagccagg taaaggcttg agaagcattg cttttgtact gctgcacttg agacagttgc 3458581 gtattatact ttaagctttt cattgctact acaggatcgt cggaagcttt tgagattttt 3458641 tttcctgaag aaatctgcga ctggagttta tccagcttcg agtagcttga accgatatat 3458701 ctcagtgagt tttgctgtat catgccttgt gttactctca tgtgactcta cctaccttcc 3458761 tccaacaccc atgccgttga tcactttatc aagcaattcg tcttgtaaag tcaccattct 3458821 tgcagctgca ttgtatgcgt gttggaattg aatcatattc gtcatttctt cgtctaaaga 3458881 aactgcgctc atttgctgac ggtttatgtc agcatcattc agctgtgttt ctgtattaga 3458941 cgccagtcga ttagcctctt gagcttcgat ccctagctcg ccaatcagac ccgcataata 3459001 atctaaaaca ctagtttctt taccgttaat ggttatttta ccggttaaaa catttgctaa 3459061 ttttgtagca tttgcgttat cgttggctgc gccagtcagt gagaaagcaa tgtttgcgcc 3459121 ttttgaatct attatgctgt cagccacttt gatcttgccc gccgcgccct tggcaggttc 3459181 agtttcaccg ccagtaaaat caaaaaagtc tccgccttgt tcaccgctct tggtcacacc 3459241 atttctgtgc acttcattga aagctttcgc gaattcaagc gccatattgt caagatcaga 3459301 aagcatttcc gggtatacgc ccttttcttg gccatctgct gttatatacc cataagactc 3459361 tataaaccct aaaagggatc ccttgctgct aaaggactcc gcctgtacag ctgtatcccc 3459421 gattgaaata cttgatacta acccagtttc attatcatag ttggctgcaa gttctgaaac 3459481 ctcgtaattt ttaccgtcca aaacagttcc tagcgactgt ttatttttat caaggatttc 3459541 aattgataca gttccttcag cagatgcaag tgcattcccg cctgatttgt tgtagctgac 3459601 tttgatatca accattgagg ataatttatc gatcagcaaa tctcgctggt catataagcc 3459661 attcggaaga agcccgaccg gctctacttg tgcaatttgc ttatttaaac tgtttaactg 3459721 agaaagcaga gaattgacat ccaacacagt tgtatttagc tctgctttta aattcgattg 3459781 gacatttgta agtgattcag aaatataatt aaacgtttca gctacagctt gtccttttcg 3459841 agcaacaaca gaacgtgcac tttcttcatt tgtattattc gataattcct gcagggaatt 3459901 ccaaaacgaa ttgagcacac tgttcaagcc gctgtcatcc gtttcattta aaacgccttc 3459961 catttgggac agcgcttttg ccttcgtgtc atagtatccg gcactgttgt tttgaagacg 3460021 gtattggtag tcaagaaaga tatctcttat tctctcaact gattttcctt gaacgcccgt 3460081 acccatttgt cccgctgttt tttctgcatt tttagataca gcagggaaat agtcagttgc 3460141 ctccaatgag acccgctgtc ttgtataacc atcagtattg gcatttgcca cgttatttgc 3460201 agtagtgctt aacgctgcct gctgagcgct taacgcccgc cttgcagttt caagccccat 3460261 aaaggtagat gtcattttct gaattccttt ctgctaagct tttgaatcaa acagtttcat 3460321 tttgctactt ttcggcagct cagctttaat tgatttgctg taattgaagt tattttcctt 3460381 aggaaccagc atatcgtacg aaatagagat gaattgcagc gcgtctcttg tcagctgcct 3460441 attcatctca tttacttttt tcagacgtcc gagaacttga gaaagagatt cgtatagttg 3460501 ttccagctct tccttttcac tgcctgaggt tttggcgata catgcggaaa tagtattatt 3460561 ttcgctatat ccgagaaagg ccgaagttgt tttgatccgg tcatcttctg tctgcgtgat 3460621 tgcttgaata tatttttgct cttttgtcaa aatgttagaa agctcttttg ttttgccggc 3460681 tttgagcgct tccgtctttt cttcagacag cgtgagcagg tgctcatgca gaacgcaaag 3460741 tcgcttcaat tgttcaataa ttgccttcgc tgacatgggc tttctccttt tttattgctt 3460801 tttataaaaa ttaatcatat ttttcgcaat atgatttgcg tctactttgt atgacccgtt 3460861 ttcaatttgc gctttaagct gcgcaatttt ttcctgtcgt gaaccagtga ctgcgtcgga 3460921 tgcatgttgc atttctttag cctgtgatga aatttcaatt ttatcttgag gttgtgcaac 3460981 agttttttgc accgcttgct tatcataatt tttttgatat ggattaacgg attgtgttcc 3461041 aaattgattg attttcatag gattcctctc gctttccgtt gcagtcttta aacaatctta 3461101 acccttttat cgactgcgtt ttcagttagt ttagggaatc agctgttttt ggtattatag 3461161 gcatagtatg tgtctttttt actattttct ttctcgattt tcagagcatc ctcgtggttc 3461221 aaatgatcca tttgatcctt aatatcagac tggcaagcct tgcagaactt gccttctcta 3461281 atcgatgtcc cgcacctttc acaagggtat gccaaattag gaagatgagt gatctgaatt 3461341 cgcttctgcc tgatgaattt caatatcagc tcttcttcca cacctgtttc ctcagttatc 3461401 cggctcaaag ttgattgccg gttttcctgt tttcttaaaa atttatagac agtctcaaat 3461461 gatttttctt cttccttaat acacgcctga catacggttt gcagctttgt ttttaaaaat 3461521 aaagcattgc atttcggaca attagccagt tctcccatct ttttttctcc ttattagata 3461581 atatgcctgt gtcaatttct agtgattata tcggcataaa aacagaatca tttagcttct 3461641 gatcaaggta aaagatgaca ctgaagcggc ttttcctttt tctaataagc agcgggctgc 3461701 gaagtgcaag gtggcgcctg ttgtataaag atcgtctatt aaaatgatat tcataccttc 3461761 tgctgaatta ttttttgtat caaaaatgca ctctgacagc aggcgttctg ttttcttttt 3461821 ctttgactgt ttctcattat tcaggcgaat gaggggatgg tgggaaggcc ggtctaaaca 3461881 ttctgccaag agatgtgcct ggttaaatcc gcgctcttct tcccgttcct tgctcagcgg 3461941 aataggtaca agaacaaaat gcttatcggg gtaaacctta gaaaaggttg aagaaaaatc 3462001 acttttaaat gcatttatga tttctgcatc tcctctaaat ttaaaacggg agagcgtttc 3462061 tttcatcata tcattatatg tgtaaactga acggttttga cgcaatagca aactgtctct 3462121 gatccttgtt ctccacacct cgcaatccct gcatacggca tgaacagatt gaggtctgcc 3462181 gcacaggggg cagatatgtc ctgtgatttt ctttaatttg cttctgcaag aataacaaac 3462241 cttttcatca ggctttagta aaaaaagggc tctccatgta acatcttgag aaaattgcga 3462301 atcacataat aaacagatca gtttatgaat gcctcctcct gcttcgtttg acataaatcg 3462361 cttggactct ctgaaactac tgcagcagat tcagccaaaa tgacaagcat tgctgtgttt 3462421 ttttgtttat ctaccagctc agctttcgta tatgcgatct ttttaaaatc agtaacgtag 3462481 gatggactca ctttgtttaa agaaagtgcc aatacatcgt tttggcatac ttggcaagta 3462541 caggccatat gaagctggtc catatatcgg tcgagcagtt ctttcattac gatttctttt 3462601 gaattgacaa gcatttttac agctcctcat catcggttat atgagtatac tgtaccacgt 3462661 tttcaaataa tggctagtct gtacattcaa cttttgctgc caattcattc atttctttta 3462721 tatgctttct tgcatcgagc atactctttg ttttgccgaa gtgaaagtaa atgacatcgc 3462781 cgtccgcata ttctttatgc cggccggttc ttcctgcaat ttgaacaagt gcgctttccg 3462841 taaagataga cgattccgct cctagtacac ccgtttgcac cttggggact gtgacgcctc 3462901 tttccagtat tgttgttgtg attaatagat cgagctgacc atctctgaat tgctgcactt 3462961 tctcctttct atgcttgtct tccgcgtgca cagatgcggt tcggcaatga acacctttaa 3463021 agcacgcagc agccttttcc agaatagaaa cggaaggaac gaataaaaaa acaggcctcc 3463081 cttcttttac atgaaactct atccatcttt tcaccgctgg cggaatttta tttcggttta 3463141 atttcttctt ccagtttcca caccatacaa agcgcggttc gggtaaaggt ttccggtggt 3463201 gtcttgcggg gatgcgaact gaatgtaact gtccgttcag tgcttttctt tttaattctt 3463261 taggaggtgt tgcacttaaa taaacgaggg tgctgttttt ctttcttgct ttttgaacag 3463321 cgaattgaag ggtttgatca gcagaatatg gaaaagcgtc aacttcatca atgatcataa 3463381 catcgattgc atctttatat cgcaaaagct gatgcgtagt ggaaatcata agcggagata 3463441 gccgcccttt gtcatcgctt cctccgtaaa gcgctgaaat gtcagcaccc tgaaaggcag 3463501 ccttgagtct tggagcaagc tctaatacaa catcggtgcg aggtgttgca atacatacac 3463561 gcagtccttg atttaacgct gattctatac caggaaacag catttctgtt ttgccagcgc 3463621 cgcaaaccgc ccagatgagg agctcttctt tttttgatat tgcttcaatt aaaacattgg 3463681 cggctttttg ctgtccgctt gaaagcttgc catcccatgt cagcttaata gacttccagt 3463741 ttgattcatt ttcctctttc catgaatata aaggaacctc ctcactcact ctgcccatca 3463801 tgacacagga acggcaatac agcttattct ttccagatga gtgataaaaa gaaaaatacc 3463861 gctgatcagt ttgtccgcac ctattacatc tatatctccg tttatttatg gatatagaat 3463921 tttcagcagt gatatatcca ttcttgatat gccattcaat catctcatcg gaaaatgaga 3463981 gctcagtcct gagcaaatga cggcttcgaa gcgtctgctg caattctttt gaaaaggaac 3464041 tgtttttttc aactggcaca ttcacatagc acgcctcctt tcgaaacagt atgcctgaat 3464101 gaatattttc tgtccaacta ttaaaataag aatataaaaa aatctccgct ctaaaaacgg 3464161 agatttggcc ttatttaaaa caccagcaaa ttcctaacgc accttcaccc aaatgagtgc 3464221 cgattaccgc gccaaaatag ctgttataaa attcaacatg aggatatttt gcagaaagct 3464281 cttcaatgat tttcgctgct tcttcctctc gattagcgtg gataacagca gctcgcatag 3464341 gcaacccttt actcgcatct tcgtctaaaa gctcataaat tcgcgaaatt gcttttttac 3464401 gtgtgcgaat cttctcaaaa ggcacaatta ccttattgtc aaaatgaagg ataggcttta 3464461 cctttagaag actaccaatg aaggcttggg cgctgcttaa tcgcccgccg cgctgaagat 3464521 gggctaagtc atctaccata aaataagctc gaactgtttt tttcatttct tccagttctt 3464581 ttataatatc ttccggcgat gatgctccgt ttttgattaa ttcagcagct ttaagggcat 3464641 aaaagccttg agccaagcag ctgatctctg agtcaaatgg atacacatca atattgtcga 3464701 ccatcgaatc agccgctgct gcactgctga atgttccgct gatcccgctg gaaagatgga 3464761 tactgataac cgcatcataa gacttgccaa gctcttcata caacgcaacc agctcgccga 3464821 ttggcggctg agaagtcgtc gggagctcat tatgtttttt cacttcttca taaaagcttt 3464881 tccagtccaa ctcaatttct tcacggtaag tctcctccct aaaaacaacc tggagaggga 3464941 tcatatgtat ctgatgttgt tcacgcattt ctttcggaat atatgccgtg ctgtctgtta 3465001 cgactgcaat attcatagct tcgatacctg ccttattgct ttataactct attgtaaggg 3465061 aaacggcagc ctaaaaaaag acctgcctag taaaaggcaa gtctcctatt atactatctc 3465121 atttctaccc agccattttt aatggcgacc acaacggctt gcgtccggtc gtttacattc 3465181 attttttgta aaatattgct gacatggttt ttaacggttt tctcactgat aaacaatgat 3465241 tcaccaatac cgcggttgct ttttccgtct gcaagcatct gcagcacttc acattcccgc 3465301 ctagttaaaa tatgtaatgg tctgcggatt tcagggtaaa cctcatgttg agggtgtgca 3465361 gaaactccgc ttgttgcaag gcggcggaat tcgttaacga ggttgtgagt aaccttcgga 3465421 tggaggtaag atccgccctc agccactact ttaaccgctt caattaatgt atcagcatcc 3465481 atctctttca gcagataacc tcttgcacct gttttcaggg catgtgttac ataattttcg 3465541 tcatcgtgaa ttgatagaat aattacttta gattcaggat acagctctac aagctgtttt 3465601 gtagcttcca caccatttac gtttggcata ttgatatcca tgatcacaac atcaggatga 3465661 tagtgctcaa caatacgagc cgcttcgtcc ccgtcatcac cttcggctac cacttcaaag 3465721 gtaggttcaa aatccaatat ccgtttaaca ccttcacgaa ataactgatg gtcgtcgata 3465781 ataacaatgt ttactttagt cacaagccac gcctccttgt attattgttc tatatactct 3465841 agcattcggt caatatgcct tttggctcta ttttacaaat catagtcaaa gagataacgg 3465901 aaccttaatc ataataaatg tcccaagacc tattttcgaa tctattgtca tcgttccttc 3465961 caataaatct actctttctt tcatgcccag caagccgaat gatttgtttt tcttctcttt 3466021 cgcttccttc aggtcgaacc ctttaccgtt atcttttatc attaaaatca caaaatcctt 3466081 tgtgatctca actttgactg taatttcttc agattcagaa tgctttagcg cattagacac 3466141 agcttcctgt gcgagcctga agagcgcaac ctcaaactga ggcgctagcc tctgatcctc 3466201 tgtttctcca atgcactgaa aatgtatttt gaccttcccg ttatattcct cggttgtata 3466261 tagatatttt cttaaagttg gaatcaggcc taggtcatca agggccatcg gtcttaaatc 3466321 atatataatc cttctcactt cgtaaagggc attccgaaca ttttggcgga gatttttaat 3466381 ttcttggaat ccgtcctctg cgccccggtc acggaaaatc cgctcgatta attccgatct 3466441 catcataaca ttcgccagca tttgagcggg tccgtcatgg atttctcttg agactctttt 3466501 tcgctcttct tcctgcgcct caataattct taagccgaaa tcctgttttg cctgagcatc 3466561 agcaagaagc agtccaactt cgcgcaaatc ctgattcaag tagttgagca caactgtaat 3466621 ttggcttact aatgattctg accgctcaat gatttcctga agccctagca atctgcgctc 3466681 caaatcgtcc cgccgttcgc gcaattgctt ctcacgctgc tggatcatcg tcaattctac 3466741 ctgcagctta tgggcttttt cataagcatt gcggatttcc tcttcactga atctatgaaa 3466801 attacggctg acctcggata aacggtttct cgcatggcga gtttgcactt caagtttatc 3466861 gccaagctca atcacttcat acacctgctg tttaatttgt ttcagttctt cgaccagctg 3466921 ttcatactgc tggcgtgact gctccccgat ttgaaaaacc tcgtccttgc tcccgtcaac 3466981 ggttttcagc atcttcatca aaatagaatc cagcactttg gaatccatct ttgttttatt 3467041 cataatttcc ctccgtcacg gcgttgtcat atatttttat tataaatgta attgatctgc 3467101 aaattatgtc gaattataat gaaagaatgc gtatattcta gaaaaaaaca tttttatata 3467161 ctatctactc tttatgatac caaaatacgc acaaaaattc taaagactgt acgaatttgt 3467221 ataggcagtc ttttatgctt agcaggaggg tcagctagca tgctgcacag ctattttact 3467281 gtgaaagaag cgggagaaca cgagattgtt atagaaaaat cgcgttttat ctgtcattta 3467341 agccgtgttt ctaccgaaca agaggcacag gaatttatac agaaaataaa gaaacagcac 3467401 tggaatgcga ctcataattg ctcggcttat gttattggcg agaatgatca tatccaaaaa 3467461 gccaatgatg acggggaacc aagcggtaca gcgggagtgc cgatgctcga ggttttaaaa 3467521 aaacgcaggc tgaaggatac ttgcgccgtc gttacacgct acttcggagg cattaagctt 3467581 ggtgctggcg gattaattcg cgcttatggg aaatcagtgt ctgaaggatt aaatcatata 3467641 ggtgttgtag aacggaagct tatgcgaatc atgcatactt ctgcagatta cacatggctt 3467701 ggcaagattg aaaatgaatt aagggagtca caatttctgt taaaggaaat ccattattca 3467761 gaaaatgttg aattcgaaac atacgtggaa gaaaaagaaa ccaacgcttt ttctgaatgg 3467821 atgacagaac tgacaaatgg aaagagtgat attaaagagg gagagttgac gtatcttgaa 3467881 aaagccgtca atcacataaa ggagactgaa taatggctga acgcgttaga gtgcgtgtgc 3467941 gaaaaaagaa aaagagcaaa cgtaggaaaa ttttaaaaag aataatgtta ttgttcgccc 3468001 ttgcactatt ggtagttgta gggcttggcg ggtataaact ttataaaacc attaacgctg 3468061 cggatgaatc gtacgatgcc ctatcccgcg ggaataaatc aaatcttcgc aacgaagttg 3468121 tagacatgaa gaaaaaacca ttttctattt tatttatggg aatagaggat tacgcgacta 3468181 aaggacaaaa agggagatca gactctctta ttgttgttac cctggatccc aaaaataaaa 3468241 ccatgaaaat gctgagcatt ccgcgtgaca cacgtgtgca attagctggt gacacaacgg 3468301 gaagcaagac gaagatcaat gccgcttaca gcaaaggcgg taaagatgaa acagttgaaa 3468361 ctgttgaaaa cttcttgcaa atcccgatcg ataaatatgt cacagttgat tttgacggat 3468421 ttaaagatgt gattaatgaa gtcggcggta ttgatgttga cgtgcctttc gatttcgatg 3468481 aaaaaagtga tgtagacgaa agcaaacgga tttacttcaa aaaaggcgag atgcatttga 3468541 acggcgaaga agccttagca tatgcccgga tgagaaaaca ggataaacgc ggagactttg 3468601 gccgtaatga cagacaaaaa caaatcttaa acgcgctgat tgaccgcatg tcaagtgcaa 3468661 gcaacattgc taaaattgat aaaatcgcag aaaaagccag cgaaaacgtt gaaaccaata 3468721 ttcgcattac tgaaggttta gcgcttcagc agatttacag cggctttacc agcaaaaaaa 3468781 tcgacacatt gagcattaca ggttctgatt tgtatttagg gcctaacaac acatattact 3468841 ttgaacctga tgctacaaat ctcgagaaag tcagaaaaac gcttcaagag catttagatt 3468901 atactcctga tacaagcact ggcacttccg gtaccgaaga cgggactgac agctcaagca 3468961 gttctggcag cactggcagc actggcacaa caactgacgg gacgacgaac ggaagcagct 3469021 attcgaatga cagcagcaca agctcaaaca acagtacaac gaattcaaca actgattcat 3469081 cctattaaaa aatgcccggt ccttttagag gatcgggcat ttttgcgcag aaaaaaactc 3469141 cggcacataa gccggagttt ttaattcctt ttcaccagcc gtttataaaa ctttgtaaac 3469201 ggcttaaatt tttcattcac gagtcctgtc acttctgcta tgatttgcat aaaaataatc 3469261 aaaatgaaga taataaacaa agaaagccaa attgtggcac ttttaagtac aatcgcactg 3469321 atactgaaaa taaatccaat taaataaata actaagaccg acatccgatg tgaaaggcca 3469381 aaggccatca gtctatggtg aatatgcgac ttatcaggcg ctgaaatcgg ctgtttgttt 3469441 aatattcttc tgatgatagc aaatgttgta tcaaaaatcg gtacgcctaa tataataatc 3469501 gggataacga tactgaacaa tgtgacactt ttatacaggc ctaataatga aagaatcgag 3469561 atactatacc ctaaaaacag tgatcccgta tctcccataa agatttttgc cggatggaag 3469621 ttgtaaaaca aaaaccccag cgtgctggca ataacgacta atgagagtga cagaatgagc 3469681 acttttccgc cggatagcgc catgacagca atcgttgaca ggccgataac agaaagaccg 3469741 gcagcaaggc catccaatcc atcaatcagg ttaattgcgt tcgtgatgcc gacaatccat 3469801 aataccgtca gcggataagc catccatcct aactcaaatc gttctgttaa aaaaggtact 3469861 gagaaaaagt ccatttttaa gccagtgctt acaatcataa tggctacacc taattgaatc 3469921 aaaaacttaa cttttgcact taattgatat ttatcgtcaa gaatacctaa cacaataatg 3469981 atgaatgctc cgactgtaat tgccgtcatc cttgtttctg tgtaaatacc ggatgcaagc 3470041 acgcctgcaa ccaccccgat aaatatggcc agcccgccca tgcggggcat gattttgtca 3470101 tgtacttttc gattgctggg ctggtcaact gcacctattt taatcgcaat cctttttacg 3470161 attggggtta tgattaaaac tgtcagcagc gagacaataa acgcaacaac aatgcgaatc 3470221 atgcgttcgt caagcataaa gaagtctcct ttggaattaa atgaagtctt tatttatata 3470281 gagaaccgtt ccttccatta taccttctcc ttagttatta taacaagctt catcaaaaag 3470341 aaacacgtat aatcaaaaaa cgcgcatccc aatttatagg actacgcatg tttttgaatc 3470401 cctgtatatt tcataatttg tctaaataag caattccaat cttgtgtccg ggcgatgttt 3470461 cggcgcattt ctttataggt ctcgtctccg ttttgaccga gaactttttc acaagcggct 3470521 ataaaatcaa tcggatgatc gccctctaca tattcgtata catacggctt ttgcattttt 3470581 gaggttgacg gaagattagt gcctacaaca ggttttcctg ccgctaaaaa ttcaaatagt 3470641 ttcagcggaa acacagcttg attatacggt gattgtttat atggcataat gccaatgtcg 3470701 ataagctcca tataatgagg cacttctttt ggatctgccg gaccggtcca tatgacattg 3470761 ggaagcctca gcagctcttg aaacgaaaca tcaccattgg tggcatccgg gccaacccat 3470821 aaaaatgtcc aatcaggctt ttgcagtgcc gcttctttaa tcattttaaa atcgagcttc 3470881 ggtttaatcc cgccaataaa acctaacact attccttctc tcccctgcag tatactgcga 3470941 tcgggagctt gtttatttgc agaaaacagc tcatactcca caccgttttc cacagtatga 3471001 accttttctc gtcctgcagt cagttttttg tctacttcct tgtgaagata atctgatgaa 3471061 caggttattg aatctgctcg ttgtataatt ctcagctctg ccgatttaat gacttttcgc 3471121 cggaattcag acagcagatt tgatcggccg ctgatcggcg cagcccatag gtcactgcag 3471181 tcataaatga cctgatccca agaatacagc gaagacagca gcgggaatcc gggaaacgtg 3471241 taccataaac agcagcgttc accgtttgca gaagcaggtg taagctcatc gagtaatggg 3471301 gagagcttat gtctgtaaaa gacatctgta tatcgtccga aacgaaacat ttttttctgc 3471361 agcaggtctt tgacagcgaa ttgcctgatg ccagaatgga cttcctgaaa ctctttccct 3471421 tgggcacgcg gagccggaca tacccaaata acttccttcg tttcctcctg agcagctaaa 3471481 aattctgcca gccggtgcct tctgtatctc aattggtctt ttccccattc agcagtggca 3471541 acgatgacat gaatgattgc ttcttttgtt tccaccttca tcaccttttc tctctgtttg 3471601 cagctataat ctttttttca ccgcgttttt tgcatattga acaaaacacc atgttgcttt 3471661 cataaaatga agccgttcga tctccctgta gacaaaccac gtttttttcg cagccttcca 3471721 tttgttgctg gaaattgaat tattgacaag ccgatattca gccaggcatt cattcattcc 3471781 ataggcagta aatccttttt ttaaaagaga cagccatgtg gctaagtcct gtctcgttct 3471841 gatattcggc atttggatct gtcccgtttg ctccctgtca atcatcaccg tcaagcagcc 3471901 gataattgta tttttcaggg cgtcatcgta cgtcaggctt tccggcgcat gaataaattt 3471961 atcgagcggg gtcccgtcct gcgccattaa gctgtagccc gtgaaagaga acgcacagga 3472021 gcgctccatc ataaactcaa gctgcttttc cagtttgtct tttttccatt tgtcatcact 3472081 gtccaaaaat gctacgtagc gcccttgagc gcgttccaac gctttgttgc gagcaaccgc 3472141 agctccggag ttctcttcca gatacaccac atgaattctt tcgtctattt tttcatactg 3472201 ctgtaaaatg tcgcgggtcc catccgttga gcaatcatcc acgataatca tttcccaatg 3472261 aggatggctc tgatctaata ccgaatgaac cgtgtcttca atatagtcac gcgcattata 3472321 ggaaggtgta atgacagata cgagaggttt ccaattggtc atgatcacat ctccatcgta 3472381 tgattttaaa aggattctct gaaaaattca ggaatgacaa cgaacataaa ggcaatcgta 3472441 aggccaatca taacgccgag aactgctttc tttttcggag acataccgcc gcctgctgtc 3472501 tcacttacgg tttcggaatc agtaacactt gccgctttca ggttaagctg tgtgtttttg 3472561 agttcatata aaaatctctc tttatccact ttggaatcct cgctcaccga ctcgccttca 3472621 agcgcgtcta tgctgctgcg gatgacggct tctctttctg catacagctt ttgatcgttt 3472681 ttgaggaagg tggaggatat ggcgtttaag acagattccg ttctatcctt atcctcgtca 3472741 ctatagctta aagtcagtaa cgatttggat tccgtattga ttgtaagctt ctctttgatc 3472801 tctgctacat cttcatcctt ttcatcagga agcgcctcct tcaaaaagga gtcgctcttt 3472861 aatagaagcg gaatctcttc tgtgctgtta taaaccggat gatcatagct ccccacagcc 3472921 aaagtatctt cagctgtata gctcttttga tcagcgatct gtgacggcag gatatacccc 3472981 gccgcaccta atataattgg caccgctatg atccaaatga tatttttttt tatgcgacgg 3473041 gctattctta tcaatatatc gttcatataa gtctccctgc tttttgtagt ctgtttatct 3473101 gtacatcggc tcaggcattt gtctggatcg ccttaacaca ttcacggcgg cgatgacgag 3473161 cgccataaac acccaatgga aaaataaatt tgaaacagag cttgggctga tacttgatac 3473221 caggaaactg accatagcgg taataagtcc ttctgtgatc agttttgact gattttctaa 3473281 ttttctttca taaaacttgt aaagcaccca tatgaggtag gcataaacgg acaaatatcc 3473341 cagcatgatg aacaaaccaa aattagcaag aatttcaaca agccagttat gcacctctgc 3473401 cacattgtca gtatcatata cagcataatg ctcaagataa taggatacat ttcctgcccc 3473461 gactccgaat ccgtatgaat caaggaaaaa atgccaagcg tttttcagca gatttgcccg 3473521 agccacattt gatggaagcc tgtcatgaaa tgaatgcagc gtctgcgggg ccagaaacag 3473581 ctcccaaaac tttgaataga ttttgctggc gaaaagaact gcgaaaagag caattcccgc 3473641 cgccgacagc catatagcca ttctctttaa aacaggcggc aatacaatga agatgtagac 3473701 agcaatacct gcaaaaatgc ccagaaggct ggctcttgaa ccagtggcaa aaattaaata 3473761 caacgcacag agcgagagca caaggccaat tgccttgatg tatccattct taatgttttt 3473821 catcatcgtg atgtaaaaaa agaagctgat ggataaaaag gtcgcaaagt cattttgatt 3473881 aaaaaagacc gatgtcggat aatgctgctt gtactccggt ccgctgtaca atgtggaact 3473941 cgcaagatga tggtgggtga tatgattgta aaaaccaatg atcatcagaa ataccgtcat 3474001 caccagccaa atggcataaa caatcatcag ccgctccatt ttttgcacgt acatgacaat 3474061 aagataaatg aagaagatcc ccattgccaa taaggctaaa tacttgaggc caactgttac 3474121 cgacttggcc cacagcagag aaacaaggcc atatataaac caaaaggcga aaaagagtaa 3474181 aatccctttt acttgcagcc catgccatct ttcaatatgg gttcgattcc gaaccatgcc 3474241 gaaaatatga aggcaacccg ctgcaatgag cagaagccgg taaaggaaca aactgaaaaa 3474301 tccaagatga atggcaaaaa atgcattatt taaaaaagtg caggcgatca aaatatagat 3474361 tacagccata aagagccgtt cttttgttgt aaatgcggtt gcaagcgtca gtaaaaacag 3474421 gccaattgcc aacaccgcaa gcacagcagc catctgcatg aaacctatat ctttatggat 3474481 ggctcccagc aataggacga ctccaaatat agcagcggcc agtaacgcta gcgtatggac 3474541 cgctgatcgt ttgatactca catgtttaac ccctttcctg atgtttcagg agccggcggc 3474601 cgagcctagc agccggcagc ttcaaccaag taacactttt tctttttata aattgacgct 3474661 tcccaagtct ttagccaatt cttcaagcgg caagcccgga aaatacttgt cagagggttc 3474721 cgttccccga acagcgggac ggccgataga gtgataaatg tatccggctg cctgcatctc 3474781 ttcaagtgaa aataaatttc tgccgtcaat gatgactggc tgttttaaga gggttttcac 3474841 ttttacaagc tccatttctt tcacttccgg ccaatccgtt aaaatcaggc atgcatcagt 3474901 gtcttccatc gcagcataca catctgtgta atactcgacc tgttcgccaa ggatcgctga 3474961 agcttcagga atagcaatcg gatcgtatgc ttttacatgg gcgcccagct gctgcagcat 3475021 tgggataata tcaagcgctg gagcggatct cacatcgttc gtattcggtt tgaaggctaa 3475081 tcccaggact gaaatggttc tccctttgac gcttcccata acagtcaaaa gtttatctac 3475141 aatatgaaca cgctgctttt cgttcgtttc aatgacagct tcgatgagct tgaatggata 3475201 gcctgccgat tttgcgattt gaagcagcgc ggttgtatcc tttggaaaac atgaaccgcc 3475261 gaatccaata ccagctttaa ggaactttct gccgatacgg ctgtcaagac caacaccatc 3475321 agcaactttt gaaacgtctg cgccgactcg ctcacaaatg tttgcgatat cgttgataaa 3475381 ggaaatcttt gtcgccagaa atgcattcgc ggcgtattta atcatttctg cactttctag 3475441 gtttgtttta atgacaggag catggaatgg ctgatgaagt tcctcaatga tggcagcggc 3475501 tttatgactt gttgaaccaa tcacggcacg ctccatattc atcgtgtcat gaatcgctga 3475561 cccttcccga aggaattcag ggttagatac aacatcaaat gagtatctcc cctttgaggc 3475621 tttttgaacg atagattgca ccagtttccc tgttccaacc gggactgtgc ttttatttac 3475681 gatcactttg tagccgttaa gatgctcacc gattgttttc gccgccgctt tgacgtacgt 3475741 taaatcagct tcacctgttt tggacatagg cgttccgact gcaatataaa taatatctga 3475801 ggcccgaatg gcagacggga tatcgttcgt aaaggtcagg cgctgatcca gcacattttt 3475861 ttcaactaag tctgcaagcc ctggttcata gattgggatt accccatttt tcaggcttct 3475921 gatttttgat tcatcgatat cacagcaaac aactttattg ccgatctccg caaagcaagt 3475981 gcctgatacg agtcctacat aacctgttcc aatgacagct atttttttca cagcgctcaa 3476041 ccctctcctg taaaatgatc ttccaattta taatggtcgc agtgtcttac gattaaacgg 3476101 acgttttcgt gaccgtctga tactgatgat gcaaggcctt ggcgtttttt cctgcgtcaa 3476161 attgagcctg cacggtttca tacaagtcat ctgctacttc cggcttccat atttgctcat 3476221 gttcgtaccg agtgatcgct tccgccaagg cttgagcgga tttcggttta atcagcagat 3476281 gttggtgctt tccgaataaa gacgacactc cgccaacatc cgtacaaata acaggaaccc 3476341 ttagcgccag cgcctcaatc acaacagtcg gcatcccctc actgtaagaa ggaagtacga 3476401 atagatctgc cgcaagtaaa tagtctctta cctgatgatt cgggacttgg cctgtgacga 3476461 tatgcccctt ctgcgtcagc gtcgattttg cgggaccatc cccgacaaag actgccttag 3476521 gagagtcctg cagcgattcg atcgcttcag acagttcaaa aatgcctttc tctctgacca 3476581 gccggccgac atagacagcc agacgctgat cgagcgggag tccgagtctt tttctgattt 3476641 cctctttcgt ctcctcattc ccctgaaaac ggctgagctg tatgccgatt ggcaaaaccg 3476701 agctgtcaaa gcccgaaagc tttttggctt cttcctgaag cttgtggctg actgctaaaa 3476761 caactgacgc agaacctacg gcacgcttga aggctttaaa cgcacctttg ctgtaatgcg 3476821 gatagacatt cacatcactg ccatgcaagg tcaggacata aggaatttgc gctgactctg 3476881 acacgactgc cgcagccccg cccgatggca tggcaaaatg cgcatggatc agatccggat 3476941 ataggtcgcg ctgtttcatt gtttttaaaa cggctgatgc gattctccga tgaggctgcg 3477001 cccacttcag ctggccggga actgcccgat agaaaggccg gtaaaccggt atcccctttc 3477061 taatctcata ctccggtctg acatcctttt ttcgatatgt ctttttcagc atgcggacag 3477121 gtgctgaatg aaaaggccgt gggcatatca cagtgatatc aagcccgagt ttttgcagct 3477181 cttgcacctg tgtctcatga aacacaccct ctccgggttt catactgctc ggatatacgc 3477241 ttgtgatcca caaaatcttc atgacaaacg tccttttctt agtagtttgc ttttcgtttg 3477301 agggtacgct tttaccaaaa gaaagagata gcacagcgcc ccagccgcaa ctgaaatggc 3477361 cagccgcatt tctgcctgca tactgaagtg ttcggtactg aggcttacac caaacgcgat 3477421 gatgcccatc gccgcagtaa tcagaaatgg cttcataatc gactggaaat aagctgaaag 3477481 gttaagcttg atgacatatg ccaaaagcca gcgcccaatc aggaaattaa caacgctgat 3477541 aatggcatac acccatgcga ctgtcagcag gcttcccgtc tgtacagctg caaacagtga 3477601 taatccgtac agcagcagca cgccggaatc ccaataaaac gctaagtcag ctcttccttt 3477661 agccagcaac acagatccat ttggattcat gagcactctt agtattccga caatcgcaag 3477721 aacatttagg atcggaacag cagcaagcca tttttctccg aaaaccgctg tgataaaggc 3477781 gtctgacaca gacacgagcc cgattaacag cggaaacgaa acaagcgcca gcatttttgt 3477841 catattcaga aagccttctc tgatcacgct gttttcatat ttgttttttg cgaaaatagg 3477901 gaatgccacc cgtgtgacaa tcggattgat cttcaaaacc ggaatggtga caatctgata 3477961 agcgaggtta taaatcccca atgcttcagc accaataaac cggccgatca aaatcatgtc 3478021 gatatttgct cccagcctgt tcacaagacg ggatgaaagc tgaaaggctc caaaagaaaa 3478081 gaaatccttc atgcctctca aatcaaaaac aaaagcagga tgccactttt ttcggtatac 3478141 agcccaatat aaaatccctt tactggactg cagcaggact tgagaaatca cgtacgccaa 3478201 aatcgcatcc atcataaaaa ccgctatcgc taaatatccg aatgacaata catttgaaaa 3478261 aatctctatt ttgcttaacg tattaaaatg cagctgcttt tgcagcatat actgatattg 3478321 ctgtccaatt ggcgcgatca aaaacataat cgccagaatc cgaaccagaa acaccagctc 3478381 ttctctttga taaaatcccg caatgacagg actgctcaca tataaaagaa caaacagcaa 3478441 aacgcccgtc ataatgttaa gccaatacaa tgttgacagc tggcgctccg tcgcgtcgtc 3478501 tctctgaatt aatgctgcgc caaaacccat atcgagcaca atctgggcga aaactgtaac 3478561 cgttgtgatc atgccgacaa gcccaaattc tgttaaggtc atcatatttc caagcagggc 3478621 aaactgaaca atttgtatga ttgtaataca catggttgaa atacttgtcc actttgcacc 3478681 gctcatgatt tgttttgtaa tacttggcat catattccct acttcttttt aagctcagat 3478741 tgatggtgaa taatggaatc ccgttttatc ttgcaccatc acccgtccaa actactttac 3478801 aagtttttaa cataattttt aattctaaag tgaaagtcag attgcgaatg taatataaat 3478861 caaatatcag cttttccttc ggcgtcatat cgtaaccgcc gttcacctga gcccagacgc 3478921 tgtgtaaagc ctggaatctc attctggaat ttttccgtaa atacgggccg ttccggacga 3478981 gggccaatca tactcatatc gcctttcagc acattaaaca gctgaggaag ctcgtcaatt 3479041 ctcgttcttc tgataaaagc tccgatcctt gtcacccgcg gatcttgctt ctgtgcccaa 3479101 accgccccag acttctcggc atctattttc atggaacgaa gcttataaag cttaaatggc 3479161 ttcccgcctt tccctacgcg ttcctgcgta taaatggcag gccccggcgt ctccaaacaa 3479221 atcaaaattg aaaataccgc aatcattggc agcgcaatcg ccaatccaat gagcgcaaac 3479281 caaatatcca ttacgcgctt tattgccaaa taacgagccg tcttttcaga taatgtaaaa 3479341 gaatgtattt gttgaactga gaattcacga ctcacattca tgcttttctc tgcactcact 3479401 gacacacacc tcacgatttg tttgggatgt tatgatgacc tatgccagtc agtttagcag 3479461 acggatgtta attggatgta aatggtatgt taagaagtgt gaattacgtg ttttttctga 3479521 taaatgttgt taatactctt ttactatttt atatacaagt cctatttgtt ttaatcattt 3479581 catataaaaa agagacaaat ctgtgattag atttgtctct ttcgattatc tgtaataaga 3479641 tactgtgccg tcatgaatag cttgtgcagc tttatcttta taaaccgctt gcttcaattt 3479701 acttgcatct gatgcattag tgataaaggc agtttcaact aaaacactcg gcattttaga 3479761 atatttaata acatagaaag cagctgtttt tactccccgg tctctcgttc caagattagc 3479821 cgctaacttt ggttgaattt gttcagccag tctcttgcta tttgcagctt gatatgttgt 3479881 atcgtagtac gtctcacttc catttggtga tgagctatca ttagcatttg catgtatact 3479941 gagaaataaa tctgcttgtg cagaagctgc tttatttact ctctcctgta aagaataaaa 3480001 agtatcatta gatcttgaca gtactggaag agcacctgaa gcatttagct ttgtattgac 3480061 tcttttcgct atatcaaggt tgacttcttt ctcaaggagt ccattgccga ttgctcctga 3480121 atcttgatca ccgtgacccg gatcaataaa gattgtttca cctacaactg gattctttag 3480181 ctgattagca acctttgtgc ttacggcagg agtgtttccg ataatcataa agtttgacat 3480241 gtttttactt ccaataattt tacgggctcc tgtagataaa ttttcaccat ttgtaagaat 3480301 aagagattgc ttcttcttag ctgccagtgt agctcctgca atagagtcag ggtagctgaa 3480361 tccattgctt acatatacgg tgcttgttga taaattaagt ttttgtacga tatttgcagc 3480421 aagctcatat ctgtttgaac cgctaattct tgtaggagaa ggtaacttgt tgtataccgt 3480481 attgctgata cttccagtgc ctcctacaac aacggtactc gaaattccct tatcttttat 3480541 cacagacgta gtcgcactat ttatagatgt tttatttgta aaaagaattg gatacccgtt 3480601 tttcgctgca taagggatga cggccggagc gtctgcatat aagaagccgt tcaaaataac 3480661 agcttttgaa gtcgcaccca tcgcttttgc cacccgtgca gccgtatcat aacggttgct 3480721 tcctgcaatt cgtttaatac ttatccccaa gcttttaatc tggttagcag tgttagaaga 3480781 aacagcaggt gttccgccta caataattac atttttagtc tgcatctctt tcaatcttgt 3480841 tttcgtttca tatgaaagct tatcagaatt agtgtaaagc aatggcgcat tcttctggta 3480901 agcaagaggt gctgctgaaa tagcatctgc ataggaactc ccaccaacaa ttacagctgt 3480961 acttgctgtt gaatacattt gctttgatat ttgtacagca gtgccgtatc tattgcttcc 3481021 cccaactctt ttcactgagt tatcggccaa agctgttggc acaaaaagta tgagccccag 3481081 aaaacacatt gttaggactt ttatataaga acgcaattga tttcctcctt aaatggcgtt 3481141 atatcctaaa ataatcaata acttgtcaga gttgtacctg gatagtaaaa tttcaaaatt 3481201 gaactatatg aatctccagc ttctgctctt gcttttgctc catattgact cattccgatc 3481261 ccgtgaccat atcctttacc gctgattgtg tactttgaag tatctttttt tacagtcaca 3481321 taagtacttt taaatacagt cgctccaatc attgttctta actcacttgt tggtacacta 3481381 atggttgtaa ttttgctcaa gttataggag ccagtactgc ttttaacaaa atacttcact 3481441 ttcatcgatg ctgtttttgc acgctgccct tgtgtcgttc cactaaagct taaatcgtca 3481501 atacttgcaa ttttgacaga atcagcgctt gtttctttat ttttcaagat ccagttctta 3481561 actccggaaa gtcttgcaga atcagtttca gtcgctgaag accaccaaga agaaggcttc 3481621 gttaagtcca aagatttcgt atctagctgt tgttttgaca aagtaagcgt ccagcctatt 3481681 tgaggatcct ttgtatcttt ttttgcaatc aagtaaggta cacttgacga ccacacttca 3481741 ttactagctt ctgtgtaacc accattactg gaagaataag ctgcagttat aagagatcca 3481801 ttatatttca gaactttccc cttcgtttgc tctaccgctt tattggtatt cgaattccaa 3481861 ctgtagccac cataaacttg aaaagcggtt gtatcaggta cagtagttcc tgtttttgtt 3481921 attgagtagg ttcttgcagc gacagtctgt gctttaagag cctcaagtga ccagctagca 3481981 ggcatttcat tcggaattac tccttttaag taatcctcaa atggaatatt ctcatttacc 3482041 ggtcggatat atttagtaga ctcaatagag aaattaaccg tgccaagata ctgctttcca 3482101 tcaagactaa ttctgtttga agtagaatag ttttctggtt taattcttag ggagtttccg 3482161 taagttttga tgttttcaag gtttaatttt ccgctgttga tttttagatt ataggtgcca 3482221 ccgtcagcta aataaaattc atcagcaagt gaattctcaa cttcagcaga aattgaactg 3482281 gtacttccaa taaagtcgta tgcatatgtg gctttatctt tcgttatact tttagccgca 3482341 gccggaacgc tatcttgttt aacaaataaa atttggctgt ttttcttcga ggcaagcgaa 3482401 gcgcctatca atacgtctgc atattttgtc ccgttcgtca ttacgacttt atcagccttc 3482461 aactttagtt gcttaattat atttgccgta agttcatatc tggttgatcc aggaatcctt 3482521 tgcacagttg aagttttttt aatttggttt tctacactat cactgacgct aaatgaactg 3482581 cctataatga tgacttgttt tggcaaatca taatccggaa gcttgtcttt ctctgtaagc 3482641 aaaatagggt atccgtgtgc tgctgcatat ggagcaatgg ctaaagcgtc ttgaaatact 3482701 cttccggtta caacgatcgc tttatcatag ctgcccattt gctttgcaat attttctgat 3482761 aagacatatc tattttttcc gcttatcctt ttcacagcgc catatgattt cagcttgttt 3482821 tctacgtctt ttgaaatgct tcgcgctccc ccaatgatta aaatattatc agggttaaac 3482881 ttagcaattt gtctttcagt agtttttgtt aacgtgtcag gctgagtaaa taaaactggt 3482941 gcgttcagtt ttttcgccaa tggaataaca ggcaatgcat caataaaaat atctcggttc 3483001 accaatatca ctgtattagg atttttccac tggctgttgg atgcaagagt cgcagtttcg 3483061 tatcgtgaag cgcctgcaaa acgatccgta acagcaacat tatctccagt tactttataa 3483121 aatcctgttg gcgatagact gatgctagat ttatttccaa tataatttaa caatttaact 3483181 gagatgtttg agtctgctgc aaaagaaact gatggaatca ataataagat tgcagcaagt 3483241 gaacacacta tcaattgttt gcaagatttc aaaatttcag gttcctccct atatcttagt 3483301 tggcacgttc aatatctttt aacagaagct gaccctcatc atttttttca tatgtaatcg 3483361 tgaccttatc tccactgtta aacttatcaa gatcacttgt cgattcttca gtgatatcaa 3483421 gactaaccgg ctcattatct actgttactt ctattgtatg agtatcagct aaccctacat 3483481 aagtaccttc ttttgtttca atgttactgt ctggcgatac atcttcacct tgactctttt 3483541 gactattaac cccgcaaccc gaaagaagca atataaagaa cagtaaagca ataaattttt 3483601 tcattttttt cacctcatta tattttatcg tcaacctatt ttatatttta aagaaaaatt 3483661 aagaaacaat gaaacttttt tttataaaaa acgactattt taggatttca ttcttgtatt 3483721 aaatagagtt gtatttattg gaaatttaac tcataatgaa agtaatttaa cagacgaggt 3483781 gcaaaggatg agaaacgaac gcagaaaaaa gaaaaaaact ttattactga caattttaac 3483841 gataatcgga cttcttgtac tcggaactgg cggctatgca tactacttat ggcataaagc 3483901 agcttcaacc gtggcaagta ttcatgaaag cattgataaa tctaaaaaga gggataaaga 3483961 ggtcagtatc aataaaaaag atcctttttc cgtcttaatc atgggtgtgg atgaacgcga 3484021 cggcgataag ggccgtgccg atacgctcat ttatatgacc gttaacccaa aaacgaatac 3484081 aaccgacatg gtcagcattc cgcgtgacac gtatacaaaa attatcggaa aaggcacaat 3484141 ggataaaatc aaccattcat acgctttcgg cggcacacag atgacggtag acactgttga 3484201 gaacttcctc gatgttccgg ttgattattt tgtgaaagtg aacatggaaa gctttagaga 3484261 cgttgttgat acacttggcg gcattacagt taacagcaca ttcgcgttca gttatgacgg 3484321 ttattcgttc ggcaaaggag aaatcacgct gaacggaaaa gaagcgctcg cttatacccg 3484381 gatgagaaaa gaagatccga gaggcgactt cggacgccag gaccgccagc gccaagtcat 3484441 ccaaggtatt attaataaag gcgctaatat ttcttccatc acgaaattcg gagatatgtt 3484501 taaagttgtt gaaaataatg tgaaaacgaa cttgaccttc gataacatgt gggatatcca 3484561 gtccgattac aaaggtgcgc ggaaacatat taaacagcac gaactaaaag gtacaggcac 3484621 gaaaatcaat ggaatttact actaccaagc tgatgaaagc gccctttccg atattacaaa 3484681 agagctgaag gaaagcctcg aaaagtaaaa caaaaagaag cttcgcacaa tgtgcaaagc 3484741 ttctttttta tttgcctgta aatgaatccg gttgttcttt tcgatacccg taatgaaaca 3484801 gcaattcttc cacaatccgg cgggaagcct ctccatctcc atacggatta gaagcctggg 3484861 acattttctt gtactcatca ggatcagtta acagctgttt tgcaagctga taaatgtttt 3484921 cctcatccgt acctgcaagt ttcagcgttc ccgcttccac tccttcaggc cgttccgtcg 3484981 tatcacgcag aacaagaacc ggtttcccga gagatggggc ttcctcctgc acgccgcccg 3485041 aatcggtcaa tataaaatgc gatttcgctg caaagttatg gaaatcgatc acctctaaag 3485101 gttcaatcag atgcactctg tcagaatcac caaaatgctt atgagccgct tcccggacaa 3485161 caggattcag gtgcacaggg taaacgactt gtacatcttc aaattcccct acaattctgc 3485221 ggatggcctt aaacatgttt tccattggct cacccaaatt ttcccggcgg tgagcggtca 3485281 agagaatcat tttatcctca cccacctgat cgagaacagg atgtgagtaa ccatccctaa 3485341 ccgttgtgtt gagtgcgtca atcgctgtat tgcccgttac aaaaatagag tcggcctttt 3485401 tgttttcttt taataaattg tctttcgcct ggcctgtcgg agcaaaatgc aaatcagcaa 3485461 tcgcccctgt catctgtcga ttgagctctt ccggaaacgg ggaatactta ttccctgtac 3485521 ggagccccgc ctccacatga ccgacagcaa tttgatggta aaaagcggct aggcttccgg 3485581 caaacgtcgt cgtcgtatca ccatggacaa gcacaatatc gggtttgata tctttaaaca 3485641 actcatccaa tcttacaagt gcgttagacg taatctctgc cagtgtctgc cgctccttca 3485701 taatgttcaa atcgaagtca ggcttgatgt gaaacgcatc taacacctga tcgagcatct 3485761 gtctgtgctg tgcagttacc gttacatagg aatctatttc aggatatttt ttcaattcaa 3485821 gcacaagcgg tgccatcttg atcgcttcag gcctggtccc gaaaacggtc atcactttta 3485881 gttttttcat atttgtcacc tggttttctg ctatagtaaa taaattcata ctacatattc 3485941 tacatgaaaa tgcatcattt taaatcattt cattcttgat tcaaataaaa tgatataagt 3486001 tttaatatta aggataaagc ttgtttaaaa atggtttatc cgatatcata aaaatgtgta 3486061 aaaacatatt gaaaagggta aatagagaat agtttaacca taaatttttt cgatcataag 3486121 gaaggtgcct tttaaatgaa aaaagtacgt aaagccataa ttccagcagc aggcttagga 3486181 acacgttttc ttccggctac gaaagcaatg ccgaaagaaa tgcttcctat cgttgataaa 3486241 cctaccattc aatacataat tgaagaagct gttgaagccg gtattgaaga tattattatc 3486301 gtaacaggaa aaagcaagcg tgcgattgag gatcattttg attactctcc tgagcttgaa 3486361 agaaacctag aagaaaaagg aaaaactgag ctgcttgaaa aagtgaaaaa ggcttctaac 3486421 ctggctgaca ttcactatat ccgccaaaaa gaacctaaag gtctcggaca tgctgtctgg 3486481 tgcgcacgca actttatcgg cgatgagccg tttgcggtac tgcttggtga cgatattgtt 3486541 caggctgaaa ctccagggtt gcgccaatta atggatgaat atgaaaaaac actttcttct 3486601 attatcggtg ttcagcaggt gcccgaagaa gaaacacacc gctacggcat tattgacccg 3486661 ctgacaagtg aaggccgccg ttatcaggtg aaaaacttcg ttgaaaaacc gcctaaaggc 3486721 acagcacctt ctaatcttgc catcttaggc cgttacgtat tcacgcctga gatcttcatg 3486781 tatttagaag agcagcaggt tggcgccggc ggagaaattc agctcacaga cgccattcaa 3486841 aagctgaatg aaattcaaag agtgtttgct tacgattttg aaggcaagcg ttatgatgtt 3486901 ggtgaaaagc tcggctttat cacaacaact cttgaatttg cgatgcagga taaagagctt 3486961 cgcgatcagc tcgttccatt tatggaaggt ttactaaaca aagaagaaat ctaaacaaaa 3487021 aggctattgg acattcatcc aatagccttt ttttatttca acatcaaagt caatgtatgc 3487081 tcttcattat caactgcgaa gacctgatca acggcctgcc gcaaaaatta ataatcccag 3487141 acaaacacac tgattgtaga gttaaacaaa ctaaatgaaa acataaatac aaacatgcag 3487201 attaaatagt aaatatcttg tattcaatgc aagctaagta aacaccactt gctaaaagaa 3487261 caatgactaa acaaccagca ttacaaaata attaaataaa tttgaagcaa ttacaacaga 3487321 aggcagtgaa ctgtcggaaa gttcattttg gctaccatat taatcccttt aactacgctg 3487381 ttggatttat caagaattgt cgggctaata gaaaaccacg gaatcaaacc agccagcatt 3487441 caaacgataa aaggcacttc tccgatacct gttatgacca gcttactgtt gcgcatccca 3487501 aatacaaacc agtacgccat cattagaata aggggattta aaacctgcca taatacacca 3487561 aaataattga ttttttggat ctttcggtta aagaaattta aaagtaccag tgaatattgt 3487621 aacaaatgtt gagttttttt cacttttaaa aagtaaagag aagtctcgca gaacttctcc 3487681 caacatttga agtgtcaata taaaacaaac caacctcatt tagcaacttt attattatct 3487741 aattccaaaa tagcattata aatacgattc ctattatttt tatcagtata tgcaaaaaag 3487801 ttatctactc tttttctata cttatcttcc atacgactat tgtttttcat ataatagata 3487861 actttatcca ctaagctatt atgattttct aatacatcac caaaccccat ttttttataa 3487921 tcataataat caagtttaaa atggtatgac ttttcgtatt gataataaat aacaggtttt 3487981 ttctcatatg caaaatcaaa cgcaacagat gaaaaatcag taatcattat attagaagaa 3488041 ttaaatagca tttgatagct gctgttatag tcggcaaact ccacataatc atgcttttca 3488101 aagtctacaa tctgttgctg aatatctggg tgaggaaaaa aagttatttt ataattattt 3488161 ttcttagcaa attcgattag ccgttcatca ttaatcaaag cattatacct agaaaaatat 3488221 tcactatctt taaatttcgg gttgtacggt cttactcctt ttgcctgatc tttcggtaat 3488281 acaatatctt ttctccaagt cggcattatt agaagttgct tttctccctc actcttctta 3488341 agattatcgt atctcggaaa tccacccaac aaaatattct cttttttata gttgtaattc 3488401 cctttcacaa tagaccgata ttcaggtttg gcagaagtga ctaataattt gatattcttg 3488461 ttgtatttgt ttaaccattc agaatgatct gccattgtta ttccgtgctg taaaaagata 3488521 aactcaaagt taaataaatc tctaaaataa atctccatat taaaaaatgg atttacaacc 3488581 catatatctg catgtgtcga tattactttg gaagaggata aggttaaaat tttatgtcta 3488641 aaagatctgt atggtatgac ctttccatat tttttgattc tgtcgtaatc cttgctatct 3488701 ttttttatta taaagtattt ttttacccca tcattcttgt tgattgcata tttaaagagg 3488761 tgctcggcat tatcatcagc tttgtcttgt ctgtctatga ataaccatac tggttttcta 3488821 ttaaaaatag tgaaaacatg gtgtaccatt cttgccatca gtgccttctt aatcgctgat 3488881 tttcgttttt ttgatttttc ccctgattta tgtagggatt ttaagaaacg aaactctttt 3488941 ataaatctat ttttaaaatt gttttttttg aacattaatt ttttataatt ataataaaaa 3489001 atataatctt ttttagccac ataagtatta tataaatcgt ttgacaaacc tgaatacttg 3489061 aaaaaacgaa gttttgtcaa cttccttttt ttacccttag ttataaaaaa ctcaatatga 3489121 tgattatctg ctagatgacc tttgggaata tctattgaaa aaccgggata tttttttatt 3489181 acttctccta aacttatata atcattatgc tgtcttttta tattctttgc ttttattttt 3489241 gtttcgccaa ttttagcata aaacttaaaa cctttagaat taaacagcga gctccaaaag 3489301 ccttctatgt gaatggaatc ctcattttct tctaaaattt caatagttaa agtttgatcc 3489361 gataatttcg aaacaatttt accttctctg tataaataat aatcctgttc agtttctctt 3489421 tcatatacat acctactata attttcaccg tgctttattt ttaaagcatg atataaatag 3489481 aaatggctga cactttttgt ttcaatgatg acatcgtcgt caatatacga caatacttct 3489541 cgaatcaatg ttaaaaattc actgtattca ttttcgtcta aaggtgtttc actgatatcc 3489601 ttaatcaata atttccactt caaatcatgc ataaccatat attgaagaaa taaaggtatt 3489661 ttctgttcat gattttttat aatatcgatt aaattctttg agaaagtgat aagtgaatgg 3489721 ttaaaccaat tcttatttgc tttagcagtc tgcatggcag atgatccatc ttctctaact 3489781 ctataatggt attttgcctc tttaaccaga ccatactttt tcttttgcga tatgattaaa 3489841 ttaactagtt tggcatcttc acctatttta caattttcat caaacctgat atttttcaag 3489901 gcatcttttt ttataaatgt agaacaacaa tgagttaata tatgatgcgg ttctttttct 3489961 acatccaaaa ttcttgtaga agaaaactta ttatttagat tatgttctcc agttcttcct 3490021 tctgcaaaaa aaatagggat tgctacaata tcaatttcat tcttatgttc gtcaaagaag 3490081 tttaaaacat tttcgaatgt tccttctgaa actaaatcat ccggatccaa aaattgaata 3490141 tatctacctt cagcatactt taaaccataa tttcgagcac tgctcactcc gccattctgt 3490201 ttctttgcat agacaatgtt attgggatat ttctgagcat attctttaca aatgatttca 3490261 cttttatcgg ggctatcatc attcaccagt attaactgaa tattctcaaa accaatagtt 3490321 tggttaatga tactttctat agcttcagtg agatacaact caacattata aatcggcatt 3490381 ataacactga aatcatagtt aaaacttttt tcgttcataa aagattactc ctaacataat 3490441 gtttatatga ataagaattc gggtaaataa aattaagaaa caagagagta ctaatttttg 3490501 caaaacaatt ttaatttagt aaaatgtatg aaaagcattc cttacctttt tttaaaaacc 3490561 cttgtaagca aacttttaaa aatgttcaca tggttaagtt ctaaagaatc atttggtgtt 3490621 tttagtacaa agtcaaatgc aaaggcccaa atcggtattt cgacaacaaa accagcatat 3490681 ctaaaatctc ttaatttata tccccatact tcaattgttt ttttcagttc ttttcgtttg 3490741 cattttttta atcttttaaa atattttata tatattctgt cattttcttt catctcataa 3490801 tactggttaa taaagtgccc tgttaattca agtctaagcc cttttatttt tgccgaagta 3490861 acagtacatg aactatgcag tactctttct ttttttatat tttcaagagc ttctgtattt 3490921 tcttttaata agtgaaacat aaattcttta tagtacatcg gcatatcttg ttcttttata 3490981 aattgcgggt caataaattt taaaacttta ataaaatcat caacaaaaac tctttgttct 3491041 tgttgatcta aaacagactt ataaacatct ctatagttcg gatataaaaa cagttttata 3491101 tgatatacaa ttaaaaattg caaataaggc aaaactatat catatttgtt gaatgaatcc 3491161 atcaacaaag tcatgtaaca ttcattcaac aaatatgtgt accttttttt gttaaaccat 3491221 gaacgatcaa ctaaagaatc ctgttctttc cgttttctat aaaaatactt tccttctgca 3491281 actgctccgt atcttttttc tttcagtaat aactggttaa aaaagatagc gtcttcccaa 3491341 aactttatag attcatcaaa aaggacggta ctagttagtg tatgtcttct gtaaaaagtg 3491401 ccgccaatat aaaaatgaat agctttataa tcgttgagaa tatttataac tcttgttcct 3491461 ttttcaaatc tattatttaa tttatgtccc ccttcttttt cacctgtgta ataaacaggt 3491521 aataccgcaa tatttacatg ttcggaatca caaaaaaaat cataaacact ttgcagcgca 3491581 ttttgagaga atgcatcgtc agaatcaaga aaaccaataa atttagatct ttcgcttaca 3491641 tttgataatc cacaatttct tgcagcagaa ggtccagagt tttcaatttt catgatttta 3491701 atattattag gatatagatt tttaaaggat tcacaaattt gaggactgct gtcaacacta 3491761 ccatcatcta ttaatatcag ttctatattt tccttaaatc caattgactg gttaaggaca 3491821 ctctctattg aatatcttaa ataattttca gaattatata ttggtataat tatagaaaac 3491881 atgtttgtac ctctttattt agaagttaaa ggatcgtttc aattactctt ttagaagcct 3491941 tgcctcttct aaattacaaa atttattata aaaatcctca tagttatgat ctatataagg 3492001 attatgtaac aactctttta ccgtatctat aagttcttca cttgtttgaa gcaagtttcc 3492061 tggcgttttt tgctgaaaat taaagtaaaa acctctgata cagtctctat aagccgggag 3492121 atcatacaca aaaaatacaa ggttttttta aaaattcata ttatcaaaaa agacagaaga 3492181 ataatccata atcaataaat cactaattaa atataaatct cgaatatctt tatttaaaga 3492241 aacatcgttc acaaaatatt tatatttccc taattaaatt gttctgaaac tggataatac 3492301 cattcttaca agaataacca tagagtctcc aaggttccct cttcatttcc tctaatcaaa 3492361 ttaaagttaa atttatactg gccagctttc ttaaaattca ttatcccgca aagttggtgc 3492421 atataaaatt atttttcttt aattccttat ttgataatgt agaattggta ggggattgta 3492481 gctaaactgt ttccagaata gctttcaaat aaaattaatt tattgtttct tggcagaagg 3492541 acaaaaattt taaacaaaac tgaataaact ctaactagta aacttctgca attggttata 3492601 ataaaaattt catcagtgaa ctccttaaag agtgaagatt aatatttacg caaacaagaa 3492661 aaaaagaagc aactgaattt acttcaagcc tcttttagtt agtgcttcta taaactagcc 3492721 atatcttttc tgatttgggt agttgaaatg cctgctattc ttgtaaggta aatggcctca 3492781 tagtattcct ttgtagacaa tcgtacgatt aagtaatccc aggttctttt gctctttcca 3492841 gtagcttcat atgtccatag tgaaataaat caaacattcc gtacgtatca ctttcttcat 3492901 tagataacat caccttccaa ccttttccaa cttagaaaaa acaaaaatcc ttaactgatt 3492961 gtttatcatt tcgacatatt ttttacgttc cattaataat aaacaataat agcatatgtt 3493021 cctataaaag ttaaggctct ttaaaaatgt aaatcatcag cactttttga caatatcgtt 3493081 gcattgatgt gtatttttta cagatctgat atcttatcta tactcattac aacaagtttt 3493141 ctattccgga agagtcaatt ctttttgtcg cgttttcaag tgtaatgatt ttctttctgc 3493201 tgcgtcattt attttgtacg ccctcctcat attacttcat cgtcaaaacg tgaaggaatt 3493261 gtaatacgta gttcctaaaa attttcgtgg taaaatttag tgaagtcttt atcaggctaa 3493321 gggactttat ctaaactacg aattacatat ggagatatat agatgaaaag gagggttgat 3493381 atgatataaa cgaaaatcaa ttagataaag gaaaaactga acacttctga aaaaagtgat 3493441 aagtttcttt cactatatcc tccaaaaaga acctaaaggt cttggacatg ctgtctggtt 3493501 cgcgcctaac tttatcggcg atgagccgtt tgcgtttctg cttggagacg atattgttca 3493561 ggctgacaca ccagggttgc gccaattaac ggatgaatat gaaagaacac tttcttctat 3493621 tatcggtgtt cagcaagtgc ctgaagatga aacacactgt tatggcatca tcgccccgct 3493681 gacaagtgaa ggccgccgtt atcaggtgaa aaacttcatt gaaaaaccgc ctaaagacac 3493741 agcaccttct aatcttgcca tcttaggccg ttacgtattc acgcctgaga ttttcatgta 3493801 tttagaggag cagcaggttg gcgccggcgg agaaattcag cttacagacg ccattcaaaa 3493861 actgaatgaa attcaaagag tgtttgctta cgattttgaa ggcaagcgtt atgatgttgg 3493921 tgaaaagctc ggcttcatca caacaactct tgaatttgcg atgcaggata aagagcttcg 3493981 cgatcagctc gttccattta tggaaggttt actaaacaaa gaagaaatct aaacaaaaag 3494041 gctattggac attcatccaa tagccttttt ttatttcaac atcaaagtca gtgtatgctc 3494101 ttcattatca actgcaaaaa cctgatcatc tgtattcaca agaaaacgct tcttgctgct 3494161 gtcatacaat acatcgctat cacttaagga tagtgacgcc gggttgatag gagaaatgtt 3494221 atgaaaaata agctctgttg ctttatcatt ctccagtaca taactgattt tttcataatc 3494281 aaaattcagc gtttttctgc cgtcagcctt atttccttca gtataaccat tcaatttcga 3494341 ttgaatgctg gtgctgctgt ctcctaggaa tttcagaaag tattcatagg aagatgctgc 3494401 gttttgcgag acataagacg taaatgcagt ggcatgcaat tcagcgtgtt tcatgttagt 3494461 tgcaacagcg ctctgtttca cataataaga gtgcccgtca aactttattt tcgctgcttg 3494521 tttgcctttt gcagctaccg ttacttttgt accgaatggc agtgtaacgt cagccttctg 3494581 tttcaaaccc tgatccttat aagcagccgc tttttcattt gctataaacc cttgcttatt 3494641 gattgcagtt aagcgttcct ctgacttgcc ctttgcatcg ccatgatggt tcttcacttc 3494701 attttgcgga atagcgccaa acgaagcaat tgtacgaagc ggggcattaa agaacatcgt 3494761 tcccgccatg aagacagtca gaatagacaa aatagcaatt tgaatggcat tggccagtga 3494821 tttcggcttt ttcttctttt tgcggaaacg ggcaaacgct tcaggatctt ctttcttcct 3494881 ctcttctgtc tgctcttttt tatatgtctc tttttctttt ttcgatagct tattaaacca 3494941 gtcaataaac gctttgtact ctttcacaac cgtttttgtt tcatcaaaca tacgaagctc 3495001 gccatagtgc atccaagcaa cacggtcaca catcttttca atctgaccga ttgagtggct 3495061 gacaaagaaa atcgtttttc cttgcttttt aaactcattt attctgtcta cacacttctg 3495121 ataaaacgtt tggtccccca cagaaagagc ttcgtcaata attaaaatgt caggatcaat 3495181 atgcacggag atcgcgaaac cgagacgcga cttcatcccg ctggaatagt ttttaaccgg 3495241 ctgattaata aaatcgccaa tctcggcaaa ttcaacgatg ctgtcataca tatcatcaat 3495301 ttctttattg gttaacccca tcatcaaaca cttgagccgg acattgtccc ggcccgttaa 3495361 ttggttattc aaaccggcag caatcgcaat cagcgacggc tggccgttca tttcaatttc 3495421 accgctggtc ggcggaataa ttttagccag caggttagac atggtcgatt ttcctgaccc 3495481 gtttattcct acaaagccga ttgtctcccc ttcatacacg tcaaaggaga cattccgcac 3495541 agcaaaaaaa ccattatcct tagccggaaa aaacaatcct ttaatcttgt ccgattgttt 3495601 tttatacaaa tgatactgct ttgaaacatt tcgaaacgaa acttttagtt tcatcgtaaa 3495661 atctccttac gtattaaaga aagtcaacaa acttgtctct gaatttcata tgcaggatag 3495721 aacctactaa caataaaagg aatgtgaaca accaaaagta cagcgtgtac ttcatgtcat 3495781 ggaaaaacca tgctccatct aagaagctgt tccggaatcc ttcaataata tagaatagtg 3495841 gattcaactt cagaacaggc actaattcgg ggtggctttg accgagtttc gcattaacat 3495901 cccaaaaaat tggcaacaag aaaaacaaaa gtcttgttac ggcctgcagc aaaaattgat 3495961 aatctctaat cagcacactg atcgttgagt taaacaaact aaacgaaaac ataaaagcaa 3496021 tcatacagat gaagtaataa atatattgta accaatgcac actcgggaac acaccattaa 3496081 ctaggagtac aatgatataa atcaccatca tgatcatata actaaataag ttagatgcaa 3496141 ttgccacgga cggtagagaa ctaatcggga agttcatttt agccaccata ttaatgcgct 3496201 taaatacact atttgatcca tcaagtatag ttggactgat gaaaaaccat gggattaatc 3496261 ctgccagcat ccaaataata aaaggcactt cgcccgctcc ggttgtcaca ggaccgccct 3496321 ttctaatccc cataccaaat acgaaccagt aggccagcat ttggataagc ggatttaaga 3496381 actgccataa gacacctaaa taattcattt gatatttaga cttggtttca taagccgcca 3496441 atcttaaaat taaaggaaat gacgttattt gctctctgag tatacgcaac aaatcattca 3496501 ttttttatct tccttagact taattgtttt tgggaatctt tctgtttaaa atttgaaagc 3496561 accgctgatt attgtaacag atcctgcatt ttttttcact tctcaacaag tatctaaaaa 3496621 gctgccgaaa aatcgacagc tatacatttt ataaaataac ctaaattatt cagctttaaa 3496681 tacagtatta acaacctttt cagatgaacg tcctgactct aaatagcaaa acttatcata 3496741 gaaaggacca aaagaaaccg gaagcttata atcaggcgat gagatctgct tgatagcctc 3496801 aatcgtttct tcagtagttt ttaccaaagg accaggagct tctttttcaa aatcaaagta 3496861 gaaaccacgc aacttgtccc ggtaggtttc gatgtcaggg acaaagaata gcattggccg 3496921 ttttaaattt gcaaaatcaa agaatactga agaataatca gtaatcagca aatcagaaac 3496981 catatacaat tctcgaatat cctcataagc agaaaaatca tatgcaaatc cttcaaaagg 3497041 acctaaatca aaattctcag ctaccagata atgcattctt aagattacaa tatattcatt 3497101 tccaagttct tgtctaagtt gatgcaaatc taaatcgaga tcgaacttat aacgcccttt 3497161 tgcatagaac tgatcatctc tccatgtagg ggcatataaa ataacctttt tatcacgagg 3497221 aatatttaac ctactcttta tcaatgatat tgtttcctca ttattatcat tatgaagaaa 3497281 atcatttcta ggatatccag attcaatcat tgtcttgtta aactgaaacg cccgtgtaaa 3497341 gatctcagtt gaataaccat ttggggaaat caagtaatcc caattagaag cttccttgat 3497401 aaaattcctt ttatattttt tggtgtttgt accaggcata tggacttctt ccatatccat 3497461 tgcaagtctt tttaaaggtg tgccatgcca tgtttgtaaa tatgttgtat gactaggttt 3497521 cggaatccat aatggaagcc ggctgttaac aacccaatac tcagctcttg ccatagcgaa 3497581 gagccatttt aatgagaggc gattaatgta aggaattccc ttttcatcaa aaggcgctga 3497641 atattgttta tttacactcc aatacatttt atactcaggg tggttttccc gcatatattc 3497701 gtaaatcgct ctcggattac aactgtattg tttcccatta aaactttcaa aaatgactgt 3497761 tttcctttta actggcattc tgctagccat catgaataga gatttgtatg ttttagtgat 3497821 taacttgttt ctcatttttg tgatcttttt tatttttgat actaatctct tcttctttcc 3497881 tttaataaag tatttcatcc ttgttttcag gctatagtcg tttactctga tacctagagt 3497941 ctgctttttc tttttcttaa agacttcata acgaactggt gcgttgtttg ttttaataat 3498001 acttactaat ccttttaatt tgttttttcg atctcctaaa acaagagcag tgctgttgaa 3498061 ctgaatatcc gttccttcat cgtcattgca tatatactcc ataaaaagac gataaacata 3498121 acgtttttca tttgagaaag gaatttcttt caaaggcact ttcacttcaa aatcatacag 3498181 ttccggaaca aaaccatctg ctctcatgtt ttccaggcca tgtgtttttc tttctagctt 3498241 gattggaaat ttttcctcaa taggtgtttc tccacccttt tttaaaataa ggttcaagtt 3498301 ttttatccga tattgatttt cggaactcag gtaccccgca taacctgtta tgcttatttc 3498361 ttcagagcta atctcgattt gatcaaatct gatgattttg gcctctcttt tcaccttaat 3498421 agaaaagttg cctttatcag ttgtataagg taaaatcaaa agttctgtgg tttgatcgac 3498481 atgaaaggcg cgctcaattg aatttacttc agcagaaaga cgcttcaaga gtggttcctg 3498541 ctccgcatct tcatattttt ttcgaaattc gacataaaaa tcatatgttt gtcccatttc 3498601 aacaggcata ggcaaaacat gagcatttat ctcagtttta tactctaatg agccagtgtt 3498661 ttgaagcgga aattcagatt ccgttcctga acgtctctct ttcagcttta aaaataactg 3498721 gtaatcctct aaaaattggt gttctgaatc aattgagatt aacaattcaa gacttcctaa 3498781 attgtttttc aagcttttca aaatacattt aatcacagtg ttttcaatca ttactttttt 3498841 ctgctcctct gtataaaagc tctttccttt ttgcttcctt ttattagtgt caactactaa 3498901 ggacattaac tctcttttat ttccgtgacc ctccaagaga aattgccttt aactgttgta 3498961 tagggctcta ctctatagcc attattagta tctatactgt ttcctgacaa ttttgtttct 3499021 tcactcgaaa gtcttcgcat tgttttaata tggccatttg cattgaaaac aatataaaaa 3499081 tcaataactt gggttttatt agcagctatc ttttcaatat ttacatcttt ttcgagatca 3499141 attacaaaca gttgatcatt ttgtaagttt gttgaaataa tttcagcctt attctttctg 3499201 tccaagccca ctaaacgtat ttttttaata tcattatgat caaaattctc aatgtcaatt 3499261 tctattttag ttttatcaaa atcctcagta taggaactaa tagaaggatc tttttttcca 3499321 acctttttag agaacttctc tctttctatt cgcacctcaa tcatctgatt aagagcaaaa 3499381 gcccaatttt caatatagtt gggtcttgaa tatttttcag ccattttaaa agcttgttct 3499441 gaaaattttt gatgagtact ttcatctttc atcaaagaga taatagcttg acccaatttc 3499501 tctatattat actgttcaat gacatatcca tttgctccgt cagtaactaa gctccttgct 3499561 ccgtaatcat aatcgtatgt tacaactgga catccattgc tcagtgcctc catatttgat 3499621 agaccgaacc cttcaaaatg agaggttgaa atggttagcc aagctttttg aaactctgag 3499681 tcagggttat ccgtatagcc tttcaaaaag acattgttct gcagtttggt atcttcaatt 3499741 tcttttttta ttttttcgaa atcttcaccc gatccgaata tatcaagttt tgcttcagga 3499801 atttctttca cgactaaact aaatgctttt actgcatgta tcagattttt catagatgca 3499861 agtcttgaaa taatgacagc tttgtatttt tcactcggca cattcaatac agcgggatca 3499921 agaggcttat caattgtatg cggagtaaag aaaaacgtct cttgttcccc tgaaatcaat 3499981 ttaaaatctt ctagctgctc ctcagttata aaaaagacag catccaaatt atacatctga 3500041 ctaaatactt ctttatagcg acccttaatt tgatatttat tgctgccgta atgcttgtta 3500101 tgaataattg ctccataata ggaagaaggt gattttttca ctttaaagac atgtttgtct 3500161 tgcggtctgc tgtccactaa aaacaactta ggtttatcat tttgtttttg cagatattct 3500221 atccaatatt gacgcagttc cgattcatct tttactttta tctcaccctc aagggagtac 3500281 caaataatat gagataattg aacatctttt tcttcattgt tccatacata gagtttgtct 3500341 aaatatactt gattttggtc attaatatat tcctgcagat acatcttgtt tagctgcaca 3500401 tcataatgag taacgagaac taagtttccg ttcttcgtat attcctctct ctttatgagc 3500461 tggtttttat cattccaata gtcgacgtac cggatagttt ctccatctcc gtagtaaact 3500521 acagacattt cattgttctt cttaccaaac aatctcaaca gagtttttgc aaatttcccc 3500581 attccaactt gcttttttat ctggtcaagg cctatccttt cttcgtatga tcttttccca 3500641 tttgttctaa cacttaaaaa atcatcgaat agattaataa cacttgtgaa ttttttatca 3500701 atcttaccgt tgctgtacaa ttcatcaatt tttgaagaca actctaaatc aaaacgaaac 3500761 gttaagaaaa aggtgttttg gttacactct tctccaaata attttgaacg caataataat 3500821 gatttcgtca gaccgccata attacttggc agtccaccag agataaaata ataatccatg 3500881 tcaggaattt gttttatatt agattcactc accgcatgta aagacaattt tttactccct 3500941 ttcggcatct agaatatatg atcattgaaa tttatatcta cccggatact ttagtcacaa 3501001 aaatcaatgt aagcatcaaa aagtacttct tatttcaata agaagtactt taattagata 3501061 ttgaaccaat gatatcagga tcctaaatta taaaccagca atttcctctt tgatctttgt 3501121 tgtagagatg ccttctgttc ttgggaggta aacaacctca cactgatctt tgagaaagtc 3501181 aaatttacct tcccagtcat cccccataac aaaaacatca atattatgat caataatatc 3501241 ttgctttttt tgctcccaat tcttttcagg aattacttcg tccacatatc gaatggtttc 3501301 taaaattaat ttacggtgct catagctgtg ataagctttt ttttgctttt gtaaattgaa 3501361 ttcatccgtt gaaatagcaa caactaaata atcaccaagc tgctttgcac gctcaagcaa 3501421 tttaatgtga ccccaatgca gtaaatcaaa agttccatat gtgataactt ttttcattta 3501481 aagaaacgct ccttcctaat gttaaacact attaaaaaca ctactgacgt tagcgattaa 3501541 attctaaaaa cctgtttgta ttccttatat cgacatattt ctcgtatgtc ttcactgatc 3501601 attaattata gcataccgcc taaaaaaggt taagtactca tgaggagaaa aacattccaa 3501661 aatatgtaat tacactcaga ctccattggc accaaggtct gttgttcatt cgttcattca 3501721 attgtaaaat tggaaacata tttaaattta atgtaaagat aatgttaatc ctttgttgaa 3501781 gatttatgtt aaaatataag gtagcttgat tttgctttta gaaactctcg gtttttaact 3501841 atataaatag aatcttaaag gaaggaggag ccagacatgc aaacagagac tattcacaat 3501901 attccttatg ttaacagtaa cttaacatca tttatcgatt acctagagaa acattatatt 3501961 gatcaaaaga ttggtgctgt catttccaca gtcaaccctg aaattgcatt tgcagctatt 3502021 aaagatcggg actactttga tgtactatct tcttcaaact tcattttgcc tgatgggatc 3502081 ggtgtagtca tgatgtcacg tttgactaac aacaggcttc agtcccgaat cgcaggttac 3502141 gatgttttta aagaacttct gggcgttgct aacaaaaaga aaaaacgcat atttctgtac 3502201 ggtgcgaaga aagatgttat aaaaggtgtt gtatccaaaa tttcttctga atacccaaac 3502261 attaaaatcg caggttattc agacggttat gttcaagatc gcaccctagt ggcaaaacaa 3502321 attgcaagag caaatcctga catggtattc gtagctttag ggtatcctca tcaagagaaa 3502381 ttcattcata actacagaca cttgttccct aaagccgtat ctataggtct aggaggaagc 3502441 tttgatgtat ttagcggtaa tgtcaaacgg gccccttcct ggatgatacg tttaaattta 3502501 gaatggttct accggttaat cttgaatcca tggcgatgga aaagaatgct tagcatccca 3502561 aaatatgctt taacggtttt aaaagaagaa aaaaacaaaa aaactttcta tccaaagcct 3502621 gaaaaagatc atacaaaaca gatttaaaaa caaaactttc aaataaatgg atgataaaaa 3502681 tgaaaataag atcactactg gcgaattgct atttgtattt tttatcagca atcgcctttt 3502741 ttctgcaatg ggtgaaacct gaaagcaaag tgaccctcct gatctcattc gaagcaaacg 3502801 caaaagcgat tcttgaggaa tatgaacaag gacaatactc ttataaactt aacatcctgt 3502861 atacccagca ggcctctgct attgccgaga gcttcccgaa tgtagatgca tatttattac 3502921 aagaaaaaaa ccctatccat ctcattaaag ctgtatacct aatgtttaac agtaaagtga 3502981 tcataacaga taattacttt ctattaacaa gtgtgttaaa taagcggaag caaacgaaat 3503041 gtatccaagt atggcacgca aatggctcac tcaaaaaatt tggtttggaa gacattacaa 3503101 acatgcaacg gacgaaaact gatattaaaa ggttccaaaa agtatacagt tcgtatgatt 3503161 atttaactgt tggctcagaa gagatggcaa atatcttcaa gaaatcattt ggaataaagg 3503221 ataaccaatt attaaaaata ggtgtacctt taacagaccc ttattaccga gaaaacaaga 3503281 aaaaaatttc agatactcta aacatacaaa gaaaaaaaat aatcctctat gcaccgacgt 3503341 ttagagatta taatatgcaa tcaattcaat tgccttttac agaagaacaa ttaattcatc 3503401 agttaaaaga agaatatgtt ttatttgtta agctgcatcc cgccattcag aacaatattg 3503461 atattaaata ttccagtgat tatattaaag atgtttctaa ctatgccttg tttgatctac 3503521 tcatggctgc agacatatta atcactgact attcttctgt tccctttgaa ttttcgattt 3503581 taaataaacc cattcttttt tatacttacg atttaaaact ttatcaacag aagcggggat 3503641 tggttgataa ttatctttcc ataatacctg gaagagcctg ctatgacagt gaatcattaa 3503701 taaatgaaat tcaaacccca tttaattatt ccaaaataaa agttttttcc gatagatgga 3503761 ataagtattc tgatgggaat tcaagccaaa atttattgaa tttcatcgaa aatttaataa 3503821 gctaaatgat gacacttgtt caaaacagaa caagtgttct tttttctatt gaataccgaa 3503881 cgtatgtttg ctttaatgta attagttgct tatggcagca aataataata gaggtggtaa 3503941 atttatgaga aaaaaagaac tgtttgattt caccaacatc acgccaaaat tatttactga 3504001 actacgtgta gcagacaaaa ccgtacttca atcattcaat ttcgatgaga aaaaccacca 3504061 aatttataca acccaagtcg caagtggatt aggaaaagac aacacccaaa gctatcgcat 3504121 aactcgtcta tctcttgaag gtttacaatt agacagcatg ctgttgaaac atggaggtca 3504181 tggtacaaat attggaattg aaaaccgtaa tggcaccatt tatatttggt ctctatacga 3504241 taaaccaaac gaaacagata aaagtgaatt agtttgtttc ccatataaag caggcgcgac 3504301 tttagatgaa aattctaaag aacttcagcg attctcgaat atgcctttcg atcatagggt 3504361 tacacctgct cttgatatga agaatagaca gttggcaatt agacaatacg atacaaaaaa 3504421 taataataat aaacagtggg tgacaatctt taacctggac gatgcaatag caaataaaaa 3504481 caatcctctt tatactatta acattcctga cgaacttcat tatttacaag gtttcttttt 3504541 agatgacggt tatttatatt ggtatacagg agatacaaac agcaaaagct atccgaatct 3504601 cataactgta tttgattccg ataataaaat agtgctgcaa aaagaaatta ctgttggcaa 3504661 agacttgtcc accagatatg agaataactt ccgtgaaccg gaagggatct gtatgtacac 3504721 caatcctgaa actggggcaa aatcattaat ggtgggaatt acaagtggaa aagaaggaaa 3504781 tcgtataagc agaatttatg cataccattc ttatgaaaac ttcatgaatc atgtacctat 3504841 gcttcgatcc cctttattaa aaaccgtggg gcaccaagat acacctccag aaagatttca 3504901 accatttatt caaaccttca ttttagagta taatgctcaa aacaaaaaat ggatggttcc 3504961 gacttcaggt tatttaccat cttacacatc aaatttagtc cgaaatatta ctatcaatgc 3505021 agatggaaac ttgcaagtca cattaaatga acgctatatt agtttactgc atcaatcgat 3505081 agaaggagat ttccgcttaa aacaaaagga tatccgaatg ggatcctggt attttgccgg 3505141 cggagaaaaa tcaaatgtgc ttgaaatagg ttttatgaaa gggagtacaa aaatcagacc 3505201 cgatgatgca gccatctcaa atgcttcaag aatgagtatt tttatgattg ttgcggacaa 3505261 gattgaggtg tgataatcaa ataggctgta gctatttaat agctacagcc tatttgcaac 3505321 tttctaagtt ttttatcgat attccggaac atcaaaataa agtgtataac cgtccagcaa 3505381 tgaatacagg ctgtacatgc ggtttacttg tttgtacgcc cagccgatgt ctgttgcgta 3505441 ttgatgtgtc gctgtagctg accatctcat tttgtacagt gtgtcttgat tgtaagctgt 3505501 gttgtggata tacgatgagc ctatgaattt agctccgccg ataatggccg cttctggtgt 3505561 gaaccagccc tgctcgtacg catatttggc tccgtagtaa ttcggattgc tgtcgtatgc 3505621 tccaattcca tacatgttgt atacggtttt tccgttatag gttaatccat tggctaaagc 3505681 ggatgtcccg tttcctgttt ccagaagagc gtgtgagatt aaatacagtt cgttgatgct 3505741 atattgattg gcggcatcga taaatgcctt tgctctccct gtcaggatgc ctttacccgc 3505801 aagcactttc tgatttacct cagtaacgct gagacccgct gtctgtgaca gcttgagaaa 3505861 ttggaagtag tatttgctgt ctctggaaaa gttattcgga tccacgtatt gaactacttc 3505921 atcactgctt gcgtttcgcc agcccaaatt gatcttagcc cagccgttta tctgtccgat 3505981 gactttcact ttatcgcctt ttttaaactg gccgatcacg tttgtcgggc tgacttccgg 3506041 cgttgaccgg atatttagta catcagccgt aacagttgat gttgctgtat taatgtacgt 3506101 gagcgatacg taagccgctc cgtctgtttg cggacttact gtcatttgtt tttggaccat 3506161 atcacgaagc gagagattgt agtttgtttt catgatttgc gggccgtttt tgatcttcac 3506221 gatagatgat gtccatccgt ataattgttt tagcttcgtt gatgccgcag cagctgtatc 3506281 attgcctgtg aactgctcat ttacgctgat tttataaagc gtattgcttt tcgttgtata 3506341 gctcggggtt acacttttcg atttaagata ggttaaccca ttgttcaatg cggttttgct 3506401 gctaagctgt gttgtcacga ttttgtattg tgtatatgca gtctggcctg tttttgatgt 3506461 tgtgactgcg atatgatttt gtttgaaaaa tgttaaaacg cggtcaatct cttcttggct 3506521 gatgatagct tcagttgtga tttgatagct gctcgcagct gtctgaccgg ttttctggct 3506581 tgctactgat atatgattcg atttgaaaaa cgtgagtgcc tgattgactt tcgtttgatc 3506641 aagcagagat tcggttgtga ttttaaacgt gtcagctatt tgttttttga cggatttcgc 3506701 agaagcactt agctgatttt tctttaatat gttcaaaccc tttgtgactt ttgcttgatc 3506761 tgatgtttct tctgagatga gctgatattg attttctgct gttgatccag ctgctgtttt 3506821 tgcagctttt acttttttct gagcaaagaa ggctgctgct ttgtttgctt gctgctcgcc 3506881 taaaatcttt gccgtcgtga tttgataagc tgcagacgtt gtcgtttttt tgacgctgga 3506941 tgacgtgtaa tgccattttt tctttttaaa gaaagtgtct attttttgga gctgctgttt 3507001 tgttataccc ttcatattca cggtatatga tgtgcttttt ccaacctgtt gataactgcc 3507061 ggatacgcca gtgtttttct tgatttggct gatggcgtcc tttactgtac tcagcccttt 3507121 gaaataagct gattggacat tgtatgactc aacggttgtt ttttgattga tggacttgta 3507181 gctgcctgtg atgccagtgc tctgtttcag ctgctgcaat agagttttgg cattggcttc 3507241 acctgaaatg gcggcagttg tgaacgtata ataggcttgc cctttcactg tttcctttaa 3507301 tgatgcctgc agcccagatt ccttttggaa ggcgtttttg atctgcgctg ctctgctgtc 3507361 tcccacgatt gtgccagact gaatggttgt gacagacacc gtgtgtgtga tgggctgata 3507421 cgagctttta atccccgttt gcttggccag gctctggata agcgccttga cttttgtctc 3507481 atcagcaatg tctgatgtca tgacgttcat atagggctga gctgctccgt aagcttttac 3507541 agcgccagcc actcccgtct cctgtttcag ctttgctagg atagtgttgg cctgtttttc 3507601 tccggagatg gcacctgacg agatggtgac atatggctgt ttgcttccaa caggacttga 3507661 cgttcctgta attgatgtct gtttggcgag tccgctcagt attgctttcg cttctgattc 3507721 gctatgaatg cctgaggcgg aaatttggta ggtcgttgtt gtgcctgaag cctgatagga 3507781 tgcatcccag ccagtatctt tttccagttt ggcgacagct tgtgaggctt ggctttctgt 3507841 actgaacgta ttcgacggct ctactttata tagtgagtag tcggtatacg cggctgcctg 3507901 ggcagaacca gacatggcaa aaaaggcaag ggacgcggcg gatagaagca taggtgcgat 3507961 tagtctcttt ttcattcctt ctcctctttc ttattctatg agtatataaa actagtttat 3508021 ttatcggcac gcgcatgctt catttatagg tgaatcactt ccattttcta ataaaaaaac 3508081 ttaacctcga agtgagatta agtttaaata tgagacacga taagggtaca agttcctttt 3508141 atcgtaaaat cgggcatttg agccggcaaa ataaagtgat cacctttttt gagcggacat 3508201 gttttgtcct catacttgag caaaccgctt ccttctatca cgctgcaaat cagaaaggat 3508261 tcatcctgag ccatttcagc ttcgccattg atgtcccatt tataaaccga aaaatattcc 3508321 ccttggacaa atgttttaat ggttattcct tttcttgatt ctgtcgattc atctatatac 3508381 ccgtccacat ggggaaccgt ggcggcattg accgctttgg caaaatgaag ctctctcgga 3508441 cttccgttgc tatcaagacg gtcataatcg tacacccggt atgtggcatc tgaattttgc 3508501 tgagtctcta aaacaagggc ccccttgcac aatgcgtgca gcgttccgct cggcacataa 3508561 tagaaatcac ccggtttaat tttgattctt cgcagcaggc cctcccagtc accgctgttg 3508621 atcattgtga caagttcggt ttttgagcgg gccgtatgcc cgtaaatgat ttctgcgttt 3508681 tccttacagt cgataatgta ccagcattcc gtcttgccga gttctccctc ttcgttttct 3508741 ccggcatagt aatcatcagg gtgaacttta attgacgtat cttccttcac atccagcagc 3508801 tttgtcagaa gcggaaaccg atccccctct acgccgccga atacttcacg gtgctcttcc 3508861 caaagctcga tcaatgtctt tcctttatac gggccatttg caacagtgct cggtcctttt 3508921 ggatgagcgg aaatggccca gcattccccc gttgattctg aaggaatact gtatccaaat 3508981 ctatctcgta aagcggttcc gccccagatt ttttctttaa acacaggcgt tagaaaaatc 3509041 ggtgattgcg tcatgatccg tacccctccc ctgtaaataa ctgatcatca ttttcccggt 3509101 gcgcccctct tacaaacgcc cgtataagct gcctttttcc tatgacaaca tatgtacaaa 3509161 gcatcatctt ttcattaccc cttcaaagaa aacgcttcct atctattata tcacgtcgaa 3509221 aagaagcttt gtttcagcct tttcctcgat aagaataatt ctcctttttt gatacaaatt 3509281 aataaaaacc gtcaatatgt ttaagaagga gagaaactat gcaaatcgac tctgatctcc 3509341 agaacaattt agacacactg aaaaaaacat tgggacaaaa cgacgatatg atgttttata 3509401 catttgcttt cggagatagc agacaaaagg cgtgtttact gtatattgac ggtctgacag 3509461 agaataaaat gctggcgcaa tacgtcattt ctcctttaca aaaagaggcg ttggcccata 3509521 aggaatgctc gattgaagac ttatccgcct tttttttcgg ctttcaccac agcgttgttt 3509581 ctacaatgaa agaaatagag cagctcgttt tttcagggca agccattttg ctcgctgatg 3509641 gctatcgcgg aggattagct ttcgacacaa agtcagtcgc aacacgcagt cttgatgaac 3509701 cctcctccga agtcgtggaa cgcggcccta aaataggatt tattgaaaag ctgcggacaa 3509761 acacggcgct tttgcgtgaa cggacgagtg atcctaatct cgtcatcaaa gaaatgacac 3509821 tcggaaaaag gaccaaaaag aaaatcgctg tcgcttatat tcaggatatc gccccagatt 3509881 atgtcgtcaa agaagtgttt aaaaggctga aatcagtcaa tatagataat ttgccggaat 3509941 cggggacgct tgaacagctg attgaagacg aaccattttc aattttcccc acaatattaa 3510001 gcacagaacg accggaccgg gtcgaaagtt ctctattaga agggcgagtg tccatattag 3510061 tggatggtac gccgtttgct ttgattgtac cggctacggt tgacgaattt attcattcgc 3510121 ccgatgatta cagccagcgc tggatcccaa tgtcacttgt acgccttctt cgttattcca 3510181 gcatcctgat caccatttat ttgcccggtc tgtatatttc tctcgtttct tttcacaccg 3510241 ggctattgcc gactagaatg gccatttcca ttgcaggcag caggcttaac gtaccattcc 3510301 cgccttttgt agaggccttt atcatgatct ttacgatcga attgattcga gaagccggat 3510361 taaggctgcc taagccgatt ggacagacaa ttggccttat cggcggcgtt gtcatcggac 3510421 aggcagctgt tcaggcgcaa attgtcagtg cgcttatggt cattgtcgtt tctgtcacag 3510481 cactggcatc ctttaccgtt ccttcatacg cctataactt tccgctgcgg atcattcgga 3510541 tcggggttat gataagtgca acagcgcttg gcatgtacgg cgttataatg gtttatctgt 3510601 ttgtgatcgg ccatctcatg cgcctgaaaa gctttggcca ggattacatt atcccgatca 3510661 tggcgcagcc tggacaggat ttgaaagaca cagtcatccg tattcccacg atgtttttaa 3510721 aaagaagacc gacacgaaac gatcccgaag ataacatcag acaaaggtga tggctatgag 3510781 gaaatcagag cataaactga catttatgca gacgctcatt atgatcagca gcacattgat 3510841 tggtgccggg gtgctgaccc ttccccgctc agccgccgaa accggcagtc cgagcggatg 3510901 gctaatgata ctgctccagg gcgttatttt tattatcatc gttctgcttt ttttgccttt 3510961 tcttcaaaaa aacagcggaa aaactctttt taagctcaac agcattgtag ctggaaaatt 3511021 catcggcttt ctattgaatt tatatatctg tctatatttc attgggattg tttgctttca 3511081 agctcggatt ttgggagagg ttgtcggatt ctttttgttg aaaaatacgc caatggcagt 3511141 tgtggtgttt atatttcttg cagttgccat ctatcatgta ggcggaggcg tttattcaat 3511201 tgcaaaagta tacgcttata tttttcctat aacccttatt atttttatga tgcttctgat 3511261 gttcagcttt cgcttgttcc agcttgattt tatccggccg gtatttgaag gaggctatca 3511321 aagctttttc tctttattcc caaaaacatt attatatttc tccggatttg aaatcatttt 3511381 ttacctggtc ccctttatga gagatccaaa gcaagtgaaa aaggctgttg ctctgggcat 3511441 cgcgacttcc acattgttct acagcattac tttgctcatt gtgattggct gtatgactgt 3511501 ggctgaggca aaaacggtga catggccgac catttccctt attcacgcat tagaggttcc 3511561 gggtattttt attgaacgat ttgatttgtt cttacagctg acctggacag cccagcaatt 3511621 tgcctgtatg ctcggatcct ttaaaggcgc ccatatcggg ttaacggaaa tctttcatct 3511681 aaaaaataaa aacaatgcat ggctgctgac tgcaatgctg gctgcgacgt ttttcataac 3511741 gatgtatccc aaggacttga atgacgtgtt ttattacggg acgcttcttg gatatgcttt 3511801 cttaattgtg attacaattc cattcttcgt ctggttttta agctggatac agaaaaaaat 3511861 agggaggggg cagctgcaat gaaaacagca tcaaaattct ccgtcatgtt ttttatgctg 3511921 ctggccctct gcggctgctg ggatgtcaaa gatatcgagc aactatcctt cgccagaggg 3511981 ctggcgatcg atgagacaaa tgatcaccag tacaaactga cgtatcaaaa tcttcttccc 3512041 caaagcgaag acagccaagc atccggaaaa cccgaatttg ttaatgtaac gtcccacggg 3512101 aaaacgattc tggaagcagt cagtgatgta tccatcaagg accctcctgt ttatagcgat 3512161 catttaaaag tgatccttct gggagaaaaa ctgatgagga atcaaaatgt agaccaagtc 3512221 ctcaaccact ttatccggga tgatgagctg cggcgaagca gctatttgat ggcagccaga 3512281 gggaatgcag ctgatgtttt cacaaaagga aaccccaatc agcagcagcc gatgccctcc 3512341 gaaaaactga ttgatttgac aactcacagc ggatataacg gtaagattat gataccgctg 3512401 cgcatcggaa gagcttctgt ctactctcag aacgggtaca gttatcttat tcaagccgtg 3512461 aaaaacgaaa agggaaaagc caagtatgac ggagcaggca ttatcaaaag gggcagcaat 3512521 aaactcgttg ggtttctttc agctgatgaa acccaaacac tgtcatgggt catggggacg 3512581 atccaaggcg gtgtcatgcc gacgacagat aaaggacatc cgattacgtt tgaaattaaa 3512641 aagtcgaaaa cgaaaattaa gcccgtcatt gaaaacggaa agcctgtctt tcatatttct 3512701 gttaaaacga agggcatcct gacagaagac caaaacccga atgaaaactc ctttagcaaa 3512761 agttatttgc acaggctgga aaacattttt gaaaaaaagc ttgaacgaga tgtaaagcag 3512821 gtgatggata aactgcagca cgagtataaa accgatccgg tctttttatc agaccacata 3512881 aggattcaac accctgacta ctggaataaa gtaaaagggc attgggatga aatattttct 3512941 gagactgatt ttaagtacga tatttctttt aaaatcatta actttggcac ggtgggaaag 3513001 taagcaatca aaagggtgcg catgatcgcg cacccttttt tatgttccga cagtctgctg 3513061 ttttccggcc gctcctccct gtccgttttt gtcccgtaaa tcctgctcaa tttcttcaag 3513121 gcttcttccc tttgtctctg tcactttaaa tcggacaaat aagaacgcca tgataccgat 3513181 cgcggcataa atcaggaata aataactgat tccgatcgct tccattaata ttggataggt 3513241 taatgaaaca atcagtgtcc caacgtgcaa cattaaggtc gaaacaccgg tcccgattcc 3513301 tctgacgtga agcgggaaca attcaggaag catcacccac acaaccggtc cccagctgac 3513361 cgcaaagaca acgataaaca cgcctaaaca aatgacggtc gtccatgagg cagccggagt 3513421 gttatcgaaa aagagattta ctaaagcgag aacgatcaag ctgatcacca tgcccgcatt 3513481 cccgaatagc agtaacggct ttcttccaat cttgtcgatg attttaatcg ctactaatgt 3513541 catgagaaca ttgactgtgc cgattccgac cgtgcctaaa atcgaagcgg agtttccgaa 3513601 tccgacgttt gtaaaggtct ttggcgcata gtagatgatc gtattcgttc cgataaattg 3513661 ctgcaaaaaa gcgagtccca aacctgcaat aagcgctggg cgcacccatg gatcgaacag 3513721 ctccttcaga ccgccttcat cctgcttttc cgcttctttt atatcatgta tttcctgatc 3513781 aatatctttt gtgccacgca atttttcaag aattttcttc gctttgcttt cttcgccatt 3513841 cgtgaacagc cagcgcgggc tctccggcat aaacaaaatg ccaataagca agagcaatga 3513901 cggcacagca gccaatccaa gcatccagcg ccacgcttcg gcatcggcaa atatgtaatt 3513961 gacaatgtaa gaaagaagga tgccgaccgt gatcatcagc tgattcagtg atgacagcgc 3514021 cccgcgttta tgttttggcg ccagttcaga taaataaagg ggtacgattg tcgtcgatgt 3514081 tccgactgca agtcccaaaa tgatgcgaaa cagcaccatg actcctgtat ttggggccag 3514141 tgccacacca agaccgccta tacaaaacag cagcgcggct gccataattg ctttttttct 3514201 tccgaaacgg tcagtcagct tgccggccgc tcctgagccc aatatcgccc caaccagcaa 3514261 ggagctgaca acaagacctt ctgtaaacgc gtttaagcct aactcctttt tcataaataa 3514321 aatagctccg gaaatcactc cggtatcata gccatataac gcgcctccaa gagctccgaa 3514381 aaaataaagc catatatttg actgcttttt cataaagatg actccctttc tccatcagct 3514441 gcaatgacat tgtctgtggg atttttttag aaatctttta gcctcttttt ccggccatta 3514501 aaccttttta tttttctgat cataagtttt ccaatcattt acttgtattt ttttcaatgt 3514561 cgccgaaaca ttttacctgc tgcggcgtcc aatataaggt gattcagtac attatcgtta 3514621 tcaattttca aaaacaagaa cttataaata taggaatatt tatcgaaaaa tgtctttcga 3514681 gtagttgccc catggcaaat agaatggtac gcttcaaata ttaaagaaac gtgaggtatt 3514741 gatatatgga agaacgatca cagcgcagaa agaaaaaaag aaaactaaaa aaatgggtga 3514801 aagttgttgc cggattaatg gcttttttag tcattgcggc aggctctgtc ggcgcctatg 3514861 cttttgtaaa gctgaacaat gcttctaagg aagctcatgt cagccttgca cgcggagaac 3514921 aatctgtaaa acggatcaaa gaatttgatc ctggaaaaga ttctttttct gtattgctct 3514981 taggaattga tgccagggag aaaaacggcg agaccgtcga tcaggcaaga agtgacgcga 3515041 atgtgctggt tacatttaat cggaaagaaa aaacagctaa aatgctgagc attccgcgtg 3515101 acgcctatgt aaacatccca ggccacgggt atgataaatt cacacatgct cacgcttacg 3515161 gcggcgttga cttaactgtg aaaacagttg aagaaatgct ggatattcca gtcgattatg 3515221 tcgtagaaag caatttcacg gcttttgaag acgtcgtaaa cgagttaaat ggcgtcaaag 3515281 taactgtaaa aagcgataaa gtcattcagc aaatcaaaaa agatacaaaa ggtaaagtcg 3515341 ttcttcaaaa aggaacacat acgcttgatg gggaagaagc gctcgcttac gtaagaacac 3515401 gtaaagcgga cagtgacctt ttacgcgggc aaagacaaat ggaagtgctg agcgccatta 3515461 tagataaatc aaaatcattg agctcaattc cggcttatga tgatattgtg gatacgatgg 3515521 ggcaaaattt aaaaatgaac ttatctctta aagatgccat cggcctgttc ccgttcatca 3515581 cttcattgaa atcagttgag tctattcagc tgacgggtta tgattatgaa cctgccggag 3515641 tctattattt caaattgaat cagcaaaagc tgcaggaagt taaaaaagag ctgcaaaacg 3515701 atttaggtgt ataatgaacg ggatggcgat tacgccatcc cgttttacat atttccttgt 3515761 tgaaaattat caaagtaacg tttagcctta atttatatgg attatgtttc acaggcaagc 3515821 tgaacatact acacgaagca gcttcatttt taaggaggtt cccctacata tgaaatgtat 3515881 tgcgattgat ctagacggaa cattactgaa taaagaaagc gtcatttctg cggaaaacag 3515941 agaggcgatc aagcgggccg ttgatgccgg catcctcgtc accatttgca cgggaagagc 3516001 gacatttgat gtaaaagcgc tgctggatga cttggacatc cctatcattg cagctaatgg 3516061 cggtacgatc cacgacacgg gttaccgttt gatcagccgg acattaatgg atcaggaagc 3516121 cggtaaagcg attgctgatt acttactttc aaaaaacatt tactttgagg tatatacaga 3516181 tgaccatctg ctttctcctt ttgacggcga agctaagctg cacgcggagc ttgacattct 3516241 aaagagcgca aacccaaacg agcagacgga tgacttgtgg caaggagcca tgactcaatt 3516301 caaacagttt ggcattaaac caatccctca tatcgaatcg gtttttgacg gcggtgaaaa 3516361 catttataag cttctttgct tctcctttga tatggacaag ctgaaacaag cgaaggaaga 3516421 actgaagcat cataaaaaac tggcgcaaac ctcttcagga aaacatatta tcgaaatcct 3516481 gccggcctcg tcaggaaaag gacgcgcgtt aacaaagctg gctgacatat acggaattga 3516541 aacacaggat atctatgcga tcggcgatag tccaaacgat ttgtccatgt ttgaagtcgc 3516601 cggacaccgt atcgccatgg aaaatgcgat tgatgaatta aaagaaaaaa gcacctttgt 3516661 cacaaaaagc aatgacgaaa atggtgtggc ctactttata gaccagcttc tttcggggca 3516721 atatgcataa agaaaagact ccagagattg gagtcttttt cttttattgc acccgtatac 3516781 ttcctgcgta tttatccttc caatatgtgc tcgtgttcat attggtaatg gtcacgccgt 3516841 ttgataatgt gacatgaaca acttgtccgt ttccgatata gatggaggga tttaagcttg 3516901 ttgattgaaa gaacacaatg tctcccggct tcaggtccgc cttctcaatc ttagttccgg 3516961 cattgtactg gcttgttgcg tatcgaggca gggaaatacc ggctgctttc tggtatacat 3517021 attggacaaa tccagctgta tcaaatcccg tctcaggtgt tactccgccc tgtttgtaag 3517081 gcacttctcc gacataaagc gtcgcttcgg aaacaatcgg attttctttc gggattgtca 3517141 ggttgtcaaa tcggcgaata cccgtcatct tcgatttcca gtaatcctct gacaaatagg 3517201 aaatggttac tttttctgac cggcttgcct gaatgaacct gcctgcgccc gcataaatgc 3517261 ctgcatgtga aattcccgtt ttatacgtat tgctgaaata gacgacatca ccaggcttta 3517321 tgttctgagg ggctaccttc tcgcccactg cccactgctg ttcggctgat cgcggtagat 3517381 aaatgccgag tgcctgttga aacacatatt gcacaagccc cgagcaatca aagccctctg 3517441 acggcgtgct tccgccaaac acatatggga caccgatata tttttcggcc tcctgaacga 3517501 caggaacatc agccgttgcc ggatcggcag cgattcgtct cgccccgata taagttccgc 3517561 tccaatagct gctttttttg taattggtga tgataacccc ttttgactgt gtactgtgaa 3517621 ccatttggcc gtctccgata taaagggcgt catgtgtcgg aacagtgccg gtgcttccct 3517681 ctttcttgaa aaacaaaata tcacccggct tcaggttttc cggttttaca gctgttccga 3517741 ttttatactg gtcgtttaca gatctcggca gatgaatatc agccttactg aacacatatt 3517801 gtatcaatcc tgatggatcg aaaccctctt tcggcgtttc cccgccatat ttatactgat 3517861 atccaagcag gttttttgct tcgctgacaa tcaattctga tgatgtatca gcttccgcaa 3517921 tctccgcttt tgtcataatt ggaaccaaaa aacaaatgat aaccgccaca agcaaaaact 3517981 tcttccagtt tgccagtgtg ttcactttta ttatctcctc ctctttttgc agttttaaca 3518041 tcggtatttt tttgaatatg ttaagagact ttttaatatt tttacagaat gaatatgctg 3518101 ggcaaataaa aagagagtgt ctcatcagac actctctttt ttgaattatt tattggcgtt 3518161 taccggttct tcctgctgct ggattttatt catttccata tcaatcttct gtttttcctg 3518221 atctgtcagc tgatcattga atttaaaagc tgacataaac atgaacacga tggctacggc 3518281 aacaaacggc cagatggctt tgacaaattt catctttatc actccgatta tttagatttt 3518341 agtttgtcac tatgatcaat atcaaacgtc agttttccgt cttctacttt ccaagcgaaa 3518401 ttagagtctt tcgtcagttc gcgaataatg gttttctgtt taaggctgtc ttttttcaca 3518461 ggcgcaggtg tcgcttcatg gatatcgatc ggtgtcactt caaagcgtcc tgttccattt 3518521 ttcttcaggt gatactgaac cagtgcactg tctcttgttc tcgtccagcc ttggtcaaag 3518581 acaaagttgc cgaggctgta gaaaatgacg gttccgttat atacttcaat cggttctaag 3518641 acgtgcgggt gatggccgac gatgatgtca gctcccgcat cagacatggc tcttgcaagc 3518701 tggcgctggc ggtcatttgg atcattgtca tactcttgtc cccagtgtga ctgcacaaca 3518761 acaatgtccg catgtttttt cgcttctgaa atcataggga tgaagatttc aggatctgcg 3518821 ggcagcacgc ccggcgtatt ctttttagcc gcgaaacctt tcccggacac atcggtaaag 3518881 ccaagcgtcg caatcgttac cccgttgact ttctggtacg aaattttctt tttcgcatca 3518941 cttaagctgt atcccgctcc aacgatatca agattttgct tcgcaaattc tccaagcgta 3519001 tctttcatgc cctgaacgcc gtaatccatt gcgtggttgt tggcgctgtt gagaaccgtg 3519061 aaattcatat ccttcaagac tttcactgat tccttattcg tctgcagatg aatctcttta 3519121 tctgcttgtt tataattctt ttgataggtt accgggtttt caaagtttcc tgctacataa 3519181 tccgaggctc taaagatcgg ttcaacatat tgaaaaatac tgtctgcccc tttttgctcc 3519241 gttacttttt caacatagcg tcccatcata atatcgccta caaatgaggc tgagagtacg 3519301 tcgtcagaat acgttttgac cttcggcgtt tccgcttttc ccgcccacat gaaagcgaac 3519361 ataaggacaa aaacgatcgg aatggcaata aatacgtgct tattggtttt ctttttttgc 3519421 tgttttgtca gctttagcag cttttcatga aagctcagtt cttttttcat cgtttgacac 3519481 accttacatt aaattaagta gtaaacaaac atgatagcaa aggtcgctcc gctcaatagc 3519541 agcgtgcttc cgaacgtaat ggttaaacct tgtttctgaa tggtattggc aattaaacct 3519601 ggcacgatga tgccgattcc tcgaaattct gcgatttcaa atggtacaat cgggtataga 3519661 aaatcaaacg cgatttttag gacgatccct gttatcagca tggcagcgaa ttttctgcgt 3519721 ccgtacaaaa tcataaattt ggataaaccg tatttcacaa tgacatacgt gagcaagctc 3519781 actagcaaaa caagtaaaat aaagaccggc tgattaaaca caagtcctaa atatcccggt 3519841 acaacaagtc ctgccggcac gatccctgtt ttttccgcaa aaattaaact gagtagtaca 3519901 cctaaaatta gtgcgatgta taaatctgat ccgaacatgt ctgcatttcc ccctagctta 3519961 cgagctgctt taccttgtat tcgtggattt tttcaattaa aggctctgcg gcaccatgaa 3520021 tattgccgac gccatatatg acacggttgt gcattctttt ctttaacaat tccataattt 3520081 catctgttga cttatactct agatcatgca gtttgtctgc aggaattttg ccttcttcgt 3520141 aggcttttac gatcggttct gttgtttcac cgattaagat cagttcactt gcttcaatat 3520201 aaggcaatac gtcatttgcg aattgctgtg tccgatcgac acggtctgcg cggcagttca 3520261 tgatgatgat cggatcatcg gtcgggtaac cgatttcttt tacacgtttc catatattca 3520321 aagtagaaga agcgtcgttt gcggcaaacc cattaacaaa gtgcccaggc tcgctcggac 3520381 tgatcagcgg aagaattctc attgctcccg gatctggcgg cgcattcagc attcccttaa 3520441 atgctgtttc ttcgtcaatg ccgagtgctt gagccacacc cagcgccaga gaagcgttat 3520501 cagggaatac catgtattca aatttacgta aatactcatc tgtaattttt gagttatcag 3520561 caatgatgac ttttgtgttt cgttcttttg ctttttgttt aaagaactcg gtatattcac 3520621 tatctgtaat gacaagatgg ccattataag gaattgtagc agtaaacgct tctgcaattt 3520681 catcaagcgt cggccccatg acatccatat ggtcttccaa aacattcaca atgacgccga 3520741 tattggcctg cagaagttct tcctgaaaga tgatttgata atctgggtta acagccatgc 3520801 attcactgac aatcgcgtta gcccctcttt ctactgtttc tctcatgact tctttttgct 3520861 ctccgatatt cggcccctga ggtttccgtt taatcggctt ttcctccggt gtgtcccagt 3520921 aaatcattct tgcatctgtt cctgttgttt ttccaacagt cttgtaaccg gcttctatta 3520981 atattccggt tgtcagcctt gtcacagtcg attttccgcg gatgccgtta atattcaccc 3521041 gaacagggag ggcatcaatg tttttctgat gtcgtcgttt ttctaatatt ccgatgacca 3521101 gtatgacagc acaggctata atgagtaacc acattgcttt tcgacatctc cttctatatt 3521161 gttgtaaatt cattcatcag tatatagaat cactatgaat tctcaatcgg cattatgtaa 3521221 cataatcttc cctaatcgac taagccaaac ttctcttttg aaagagattt tatacctaca 3521281 aactgttttc tatttttgga aaacagcagg acttatacct tatcactttt taaaaaaatc 3521341 aaagagaatg cgctttcatt tttctcctga tatccttctg gacgtatagt cacaccctgc 3521401 tgtttgtatt taatatgcat ttcaaatcaa tctttttttc agcctttgtt atcaagcatt 3521461 tcctgctatc atgcgtgttt ccggttctta tgaacacaaa ataattttat cctgtttctt 3521521 aaggacaagg tcataatgtc atcctttctg catggaataa gcaatatgag gcccattcca 3521581 aaatgactaa ggaggttcga gatgaaaacg ctaaacatac gagtccgaat tctctaacat 3521641 aattaaacat tttctgggat gatagtcttt tctgtttctc cccatttaca ggtctaaacg 3521701 catgactttg aaacaatttt aataaaactt aatatttgtt caagaaatct tcatccatat 3521761 ttgtgaagac tttgtcaaaa aaagagtgaa aaccttaaat ttttcaatta tatatacaat 3521821 ttacaattag atttcttttg atatttttat tgctaacttc ggattgttca tgataatcta 3521881 tctatgtaaa cggttacata aacaaggagg agctgttttg gctacaatta aagatgtcgc 3521941 cggagcggcg ggcgtttcag ttgcgacggt ttcccgcaac ctgaatgata acggctatgt 3522001 acacgaagaa acgcgaacgc gtgtcatagc ggcgatggcg aagctgaact attacccgaa 3522061 tgaagtcgcc agatctctat ataaaagaga atcccgactg atcggacttt tgctcccgga 3522121 tatcacaaac cctttcttcc cccagcttgc ccgcggtgcg gaggatgaat tgaaccggga 3522181 aggctatcgc cttattttcg gcaacagtga cgaggaattg aaaaaagaac ttgaatacct 3522241 tcaaaccttt aagcaaaatc atgtcgcagg cattattgcc gcaacgaatt acccggatct 3522301 cgaggaatac agcggcatga attatccagt tgtttttctg gacagaacgc ttgaaggggc 3522361 tccttctgtg tccagtgacg gctatacagg agtaaagtta gccgcccagg ctatcattca 3522421 cggaaaaagc cagcgcatta cgctcttgag aggacccgct cacctgccga ccgctcaaga 3522481 ccgatttaac ggcgctttgg aaatcttaaa gcaggctgaa gttgattttc aggtcattga 3522541 gacagcttca ttttcaatta aagatgcaca atcgatggcg aaggagctgt ttgcctctta 3522601 tccagcgaca gatggtgtga tcgcgagtaa tgatattcaa gccgctgccg ttttacatga 3522661 agcattgcgg cgcggaaaaa acgtgccgga ggacattcaa attatcggct atgatgacat 3522721 tccgcaaagc ggacttctgt tcccgccact ttctacaatt aaacagcccg catatgatat 3522781 ggggaaagaa gctgccaaac tgcttttggg tatcattaaa aaacagccgc tggcagaaac 3522841 ggcaattcaa atgcctgtca cctatatagg aagaaagacg acaagaaagg aagattaaga 3522901 tgcgtaatat ttgtgtgatt ggtagctgtt ctatggattt agtggtcacc tcggacaaac 3522961 gcccaaaagc cggtgaaacg gttcttggca cgtcatttca gactgtgccg ggcggcaaag 3523021 gagcaaatca ggccgttgcc gcagccagac ttggggcgca agtgtttatg gtcggcaaag 3523081 ttggagacga tcattatgga acagctattt tgaataatct caaagctaac ggcgttcgca 3523141 ctgattatat ggaaccggtt acacatacgg aaagcggaac cgctcatatt gtgcttgctg 3523201 aaggcgacaa cagcattgtc gttgtcaaag gcgcgaacga tgacatcacc ccagcgtatg 3523261 cgttaaacgc gctcgaacag attgaaaagg tcgatatggt gctgattcag caggaaatcc 3523321 cagaagaaac ggttgatgag gtgtgcaaat actgccattc tcacgatatc ccgatcatac 3523381 taaacccagc accggcccgc ccgctcaagc aggaaacaat tgatcacgct acctatctga 3523441 cgccgaatga acacgaggct tcgattttat tccctgagct taccatttcc gaagctctgg 3523501 cgctttatcc ggcaaagctc tttattacgg aaggaaaaca aggcgtccgc tattcggctg 3523561 gcagcaaaga ggtgctcatc ccgtccttcc ctgtagaacc cgttgataca accggagccg 3523621 gtgatacgtt taacgcagca tttgccgtgg ccctggctga gggaaaagac attgaagccg 3523681 cattgcggtt tgccaatcgt gccgcttccc tttctgtctg ctccttcggt gcccaaggcg 3523741 gaatgccgac aagaaatgaa gtagaggagc tgctgtcatg aaaaaacacg gtatactgaa 3523801 cagccatctt gccaagattt tagccgacct tggccacact gataaaattg tcatcgcgga 3523861 tgccggactg ccggttcctg acggcgtttt gaaaattgat ctttcactga agccgggcct 3523921 tccggctttc caagatacag cggcagtact ggctgaggaa atggcggtcg aaaaagtcat 3523981 tgctgcagct gaaataaaag catccaatca ggagaatgcg aaatttctag aaaatctttt 3524041 ctctgaacaa gagattgaat acctttctca cgaggagttt aagctgctga caaaagatgc 3524101 aaaggcagtc ataagaacag gagaattcac accatatgcc aactgcatcc tgcaggcagg 3524161 tgtacttttc tagaaaggaa gatgaaacat gcagattgaa atgaaagaca ttcataaaac 3524221 attcggaaaa aatcaggtgc tgtcaggcgt ttcctttcag ctcatgcctg gcgaggttca 3524281 cgcattaatg ggagaaaacg gcgccggcaa gtccacgctt atgaacattt tgacaggcct 3524341 gcacaaagca gataaaggtc aaatcagcat aaacggaaac gaaacgtatt tttccaatcc 3524401 gaaagaagcg gaacagcatg gaatagcctt tatccatcag gaattgaata tctggccgga 3524461 aatgaccgtt cttgagaatc tatttatcgg taaagagata tcctccaagc tgggcgtttt 3524521 acaaacaaga aaaatgaaag cgctagcaaa agagcaattt gacaaacttt ccgtctctct 3524581 ttctcttgat caagaagccg gcgaatgttc cgtcggacag cagcaaatga tcgaaattgc 3524641 aaaagcgctt atgacaaatg ccgaggtaat cattatggat gaaccgaccg cagcgttgac 3524701 tgaacgtgaa atcagcaagc tctttgaggt cattacagcg ttaaaaaaga acggcgtctc 3524761 cattgtctat atttcgcatc gcatggaaga aatttttgcg atttgcgaca gaattaccat 3524821 catgcgtgac ggaaaaacgg tagatacaac aaacatctca gaaactgatt ttgatgaagt 3524881 cgtcaaaaaa atggtcggac gggagctgac tgaacgatat ccaaaacgca ctccttctct 3524941 cggtgacaaa gtattcgagg tgaaaaatgc ttccgtaaaa gggagttttg aggacgtcag 3525001 cttttatgtg cgttccggtg agatcgtcgg tgtttcagga ttaatgggag ccggccggac 3525061 agaaatgatg agagcgctgt tcggcgttga caggctggac acgggtgaga tatggatcgc 3525121 tgggaaaaaa acggctatta agaacccgca ggaagccgtg aaaaaaggtc tcggctttat 3525181 tacagagaat cgcaaggatg aagggctcct gctcgacacc tcgatccgcg aaaatattgc 3525241 cctgcccaat ctgtccagct tctcaccaaa gggtctcatt gatcataagc gggaggctga 3525301 atttgtcgat ctgttaatca agcgcctcac tatcaaaaca gcatcaccgg aaacgcacgc 3525361 acgccattta tcaggaggaa accagcaaaa agtggtgata gccaagtgga tcggcatcgg 3525421 accgaaagtg cttatcttgg atgagccaac cagaggtgtg gatgttggcg ccaaacgaga 3525481 gatttatacg ctgatgaatg agctgaccga acgcggtgtc gctatcatca tggtgtcatc 3525541 agagcttcct gaaattctgg gaatgagcga tcggattatc gttgtccatg aaggcagaat 3525601 cagcggcgaa atccatgcgc gagaagcaac acaagaacga attatgacac ttgccacggg 3525661 agggcggtaa tatgaaaacg gaacaactgc aaacagaaca aaaacggatt cacttcgacg 3525721 gagtcatgca aaaactcggc ccgtttcttg gtttatttat tctcgttatc attgtatcta 3525781 ttttaaatcc cagctttctt gaaccgctga atattttaaa cctgcttcgc caggtcgcca 3525841 ttaacggatt aatcgcgttc gggatgacct ttgttatttt gacaggcggc attgatcttt 3525901 ctgttggcgc tattcttgcc ctgtccagtg ctttagttgc ggggatgatt gtgtccggtg 3525961 tcgatccggt tctcgcgatc atccttggct gtatcattgg tgccgtacta ggcatgatca 3526021 acggattatt gattactaaa ggaaaaatgg cgccctttat cgccacgctt gcgaccatga 3526081 ctgtgtttcg cggactgacg ctagtgtata cagatggaaa tccgattacc ggacttggca 3526141 caaactacgg ttttcagatg ttcggacgcg gttacttttt aggcattcct gtaccggcaa 3526201 ttacgatggt tcttgccttt gtcatccttt gggtgcttct tcataaaaca ccattcggac 3526261 gccgaacgta cgctatcggc ggcaacgaaa aagccgcgct catttcaggc atcaaagtga 3526321 cgcgcgtgaa agtgatgatc tattctttag ccgggctttt atccgctctt gcaggtgcca 3526381 tattgacttc ccgcctgcat tcggcccagc cgactgcggg agaatcgtac gaacttgatg 3526441 ctatcgcggc agtcgtctta ggagggacaa gtctttccgg cggccgagga cgcattgtcg 3526501 gcacgttaat cggggtgctg atcatcggca cacttaataa cggacttaat ctgcttggcg 3526561 tctcatcatt ttatcagctg gttgtcaaag ggattgttat cttaattgcg gtattgttag 3526621 accgcaagaa gtcagcttag gagggtttta catgaaaaag gctgtatccg tcattttaac 3526681 gttatcatta tttttgttaa ccgcctgttc gcttgagcct ccccaatggg caaagccatc 3526741 aaactcgggg aacaaaaagg aattcaccat tggcttgtcc gtctcaacgc ttaataatcc 3526801 tttttttgtc tcattaaaaa agggtatcga aaaagaagct aaaaaacggg gaatgaaagt 3526861 catcattgtt gatgcacaaa atgattcatc gaaacagacg agtgacgtgg aagatttaat 3526921 tcagcaaggt gttgatgcat tattaatcaa cccgactgat tcttcggcga tctcaacggc 3526981 agtagaatct gcaaacgcag tcggtgtgcc cgtcgtaaca atcgatcgat ctgcggaaca 3527041 aggaaaagtt gaaaccctcg ttgcttccga taatgtaaaa ggcggtgaaa tggccgcggc 3527101 gtttattgcc gacaaacttg gaaaaggagc aaaggtggca gagcttgaag gcgtccccgg 3527161 cgcatctgcc acacgggaac gcggctcagg attccataac atcgcagacc aaaagctcca 3527221 agttgtcaca aaacaatcag ctgactttga ccgcacgaaa ggcctgactg tcatggaaaa 3527281 cctgctgcag ggacatcctg atatccaagc tgtttttgct cacaacgatg aaatggcgct 3527341 cggtgctctc gaggcaatta acagctcggg gaaagacata ttggtgatcg gttttgacgg 3527401 caataaagat gcgctcgctt ccattaaaga cagaaagctg tcagccaccg tcgctcagca 3527461 gcctgaatta atcggtaaat tggctacaga agcagcagat gatattttgc acgggaaaaa 3527521 agtgcaaaaa acaatatccg cgcctctcaa actagaaaca caaaaataat tgtctgatgt 3527581 ttaggaacct gcgataacgt gaatagagat atagaatgaa ttatttctct tacgtgagga 3527641 gaggaacggc atgaacaaac caacaaaact attttcaaca ttagcacttg cggctggaat 3527701 gactgcggcg gctgctggcg gcgctggcac gatccatgct caacagccag aaacaacggt 3527761 aagcattgat gatttataca gttatccgat tgattcttat ttggtatcag cagaggctct 3527821 aaatgtcaga acgaagcctt ccgcatcaag ccagaaagcc gatacgctgc acttaggaga 3527881 tagcctaaag ctgatttcct tctcaaatgc tgactgggca aaggttaagt ataaaaatgg 3527941 aaaaacagga tttgtatcca ctcattacat tgttaaagca gcgacaacgg taaaaaccaa 3528001 aacaaaaaca aaagtgtata catccgctga cggaaagagc attaagactc ttccagcaga 3528061 cacaagcgtt tcttttttag gctggagtaa aacgaataaa ggcggttttg attttgattg 3528121 ggtattcgtt gattacggcg gtacgacagg ttatatgaaa acaaaggatt tacacatgac 3528181 aaaataactg agagggattc cgcataaatg cggaatccct tttattatga attgatttgt 3528241 cacattccca agatatttct caggaaatat tgtcgtatgc tgtgtcgaaa ccttacatga 3528301 tcatcgacat ttttgttcac gctaaaaagc ggaggtgtaa atatggatca atttgaagca 3528361 gcatatgaat cgtataaagc ccggcaaaca actgccgatc aagaaaatgt tccatctgga 3528421 aaagaagaaa ttattgcggt tagaagaaat gaggaagaca atattatcgc agtgaaaacc 3528481 aatacaggaa gagagctcga ctaccctact gcgctgtcag aagcaaaatc aggaaaactc 3528541 gctcatgttg atgtcttcca taaatacggg cgtgacattt tgcgaagtga accggacggc 3528601 atcaaggaaa ataacctgtc tgagctgccg gatttttaaa caaatacagc cctgccgtat 3528661 gttggacagg gctgtatttt aaacaaaagg ctgctggatg tattcggcta accgttttgc 3528721 actgtgagaa atatcctctg cagctgcata attcacgcca tagaacacat atggaggcag 3528781 atacttcatg ccgatcagat tactcgtggc ctgaaatggt ttcaatagct cactgatcga 3528841 gtaatgattt gctccgcccg cttgatattt ttccgcttcg ctccctgttg atacagccag 3528901 catcagctcc ttgccatgca aggcatttcc ttctgaacca aaagcccagc cataagtcag 3528961 cacaagatcc tgccattttt tcaagagcgg cggagagctg taccaatata gcgggaattg 3529021 aaagacaatc cgatcgtatt cctcgcacag ctgctgttcc ttcgcaacat ctatcgcttc 3529081 atccgggtat tccttataaa gatcccgtac tgtgatattg tcatgtttac tcaattcctc 3529141 agcccacgcc ttattaacaa ctgaggtctc catatgagga tgcactgcca aaaccaatat 3529201 tttcatcaga ccacaccttt actgttttga tgttatttta tctaaaatca ggaaaagagc 3529261 caaataaaaa gaaagccctg ctaaaagggg ctttcttttt ttcttttatt cagggcttcc 3529321 ttcagttgtt tcgatatctt tcgcaaaatc agggttatcc agattcgcat taaagaaatc 3529381 cgctgtgttc ggaagtctga gattcatgtt cattttttga gaaatcgtaa ccgtgcaatc 3529441 ctcaagcaca tagtcaaaaa cgtgtccgcc tgaattgcgt ccttcgtcaa tgaagtgcag 3529501 gtgatagcca gaaacggcga ttccgtttgc ataagctggt gtcaagaaac ctacaatcgt 3529561 tcctctcacg ttgtcgaagt tgaaaatcgg ctgtgttttg accgcttcaa ccattggcac 3529621 gtaaggtttt tcttgaagtt ctactgttct tgtctgcacc tttttaaaca atccgtcaat 3529681 gcgaattgca taaaataagt ttctgcttgg cagcatgctg ttgatctctt tttcaaagtc 3529741 ttcgcgtgtc attttcgcat caattttgtg cgtcatgtcc ggtgtaaaga acgtaaatga 3529801 acagaacggt gaacggtctc cattttggac cggtgtcgcg gttccgtctg agcgaagacg 3529861 gtaaaattcg ccgtcaaacc caatcagctc tccgtcaagc ttgttaaagg ttccgatacc 3529921 gaagtctcca tatttcggaa tctctgacag ttcaaaatct ccgtcatata ctccgtctaa 3529981 tagagaagtc attgttgata cttgataaat ctggctcaca ggctgatctt tttgaccacg 3530041 gctgagcact tgaatgttgc tttctcgttt catatttccc ttcactcctt ttatttagtg 3530101 ctgttcataa aacagtgtcg tgatgcgcag agtgctagag agctttcgtt ttcatgagtt 3530161 ccccgaattc tttcggaagc ttgtcacttg ctaaattaat gttatcactg tagtcaaccg 3530221 ggacatcgat gatgacagga ccttcagcgt tcatgccttg acgcagaaca tctgccagct 3530281 ggtctggtga ttctacgcgc aagccagttg ctccgaagct ttccgcatat ttcacgatat 3530341 cgatatttcc gaaatcgacc gcagatgtac ggttatattt tttcaattgc tggaatgcaa 3530401 ccatgtcata tgtgctgtcg ttccatacaa tgtgtacaat tggtgctttt agtcgaactg 3530461 ctgtctctaa ttccattgct gagaataaga aaccgccgtc accagagaca gaaaccactt 3530521 tttctcccgg tttcaccaat gaagcgccga ttgcccaagg aagcgcaacg ccgagtgttt 3530581 gcataccgtt actgatcatt aatgttaacg gctcgtagct gcggaaataa cgtgacatcc 3530641 aaatggcgtg cgaaccgata tcgcaagtta ctgtaacatg atcatcgact gcattacgca 3530701 actctttaac gatttcaaga gggtgcgctc tgtctgattt ccaatctgca ggcacctgct 3530761 caccttcatg catatattgt tttaaatcag aaaggatttt ctgctcacgc tctgcaaatt 3530821 ccactttcac agcatcgtgt tcgatatgat tgatcgtgga cggaatgtca ccgatcaatt 3530881 caagatcagg ctggtaagca tgatcaatgt cagcgataat ctcgtctaaa tggataattg 3530941 tccggtctcc attgatattc cagaatttcg gatcatattc aatcgggtca tagccgatcg 3531001 tcagaacaac atctgcctgc tctagcagta aatcgccagg ctggttgcgg aacaaaccga 3531061 tacggccaaa atattgatcc tctaaatctc tagaaagggt accggcagct tgatatgttt 3531121 caacaaatgg aagctgaacc tttttcaaaa gcttgcgaac cgctttaatt gcttccggtc 3531181 ttccgccttt catgccgacc aaaacgacag gaagttttgc tgtttggatt tttgctatgg 3531241 ccgcactgat tgcatcatct gctgcaggac cgagttttgg cgctgcaaca gcacgcacgt 3531301 ttttcgtatt tgtgacttca ttcacaacat cttgcggaaa gctcacaaaa gcggccccag 3531361 cctgccctgc tgacgctatc ctaaatgcat ttgtaacagc ttccggtata ttttttacat 3531421 cttgaacttc tacactgtat tttgtaatcg gctggaatag cgccgcatta tccaaagatt 3531481 gatgtgtccg ttttaaacga tctgcacgga tcacgtttcc agcaagcgca acgacagggt 3531541 ctccttcagt gttcgctgtc agcaggcctg ttgccaagtt agaggcaccc ggtcctgatg 3531601 tgactaacac gactcccggt tttccagtta aacggccgac tgcttgggcc atgaatgctg 3531661 cgttttgttc gtgccgggca acgataattt caggtccttt atcttgtaaa gcgtcaaata 3531721 ccgcatcaat ttttgcacct ggaatgccaa atacatgtgt gacaccttgc tccactaagc 3531781 aatcaacaac aagctccgcc cctctgtttt tcacaaggga tttttgttct tttgttgctt 3531841 ttgtcaacac cctcactcct tattatgcat tttaaacgta aaattttaaa tatcttgtga 3531901 taagtttcac tatacactct ttggaaattg acctccaata tcgattcgcc ttatgattaa 3531961 tatgtaatac gaattattaa cctatggaaa ggaatgcata ttgaatggag cttcgccatc 3532021 ttcaatactt tatcgcagta gccgaagagc ttcatttcgg aaaggctgcc cggcggctga 3532081 acatgacgca gcctcctctc agccagcaga tcaaacagct ggaggaagaa gtcggagtta 3532141 cgcttctgaa aaggacaaaa cgatttgtcg agcttaccgc agcaggagaa atctttttaa 3532201 atcattgccg catggcattg atgcaaatcg gacaaggaat tgaactggca cagcggacgg 3532261 cccgcggcga gcaaggcctt ctcgtaatcg gttttgtcgg atcagctaca tatgaatttc 3532321 tgccgccgat tgtccgggaa tatcgtaaaa aattcccatc tgtgaaaata gaactgcgtg 3532381 aaatatcctc gtctaggcag caggaggagc tactaaaggg caacattgat attggtatac 3532441 ttcatcctcc cttacagcat acagctttac atatcgaaac cgcccaaagc agcccttgtg 3532501 ttttagcttt gcctaagcaa cacccattga cttctaagga atcaattacg attgaggatt 3532561 taagagatga accaattatt actgttgcta aagaagcatg gcctactcta tacatggatt 3532621 ttattcagtt ctgtgaacaa gcgggcttca gacccaacat tgtccaggaa gccacagaat 3532681 atcaaatggt gattggttta gtcagtgccg gaattggtat gacatttgtt ccttcctcgg 3532741 ccaaaaaatt atttaatttg gatgttactt atcgaaaaat ggaccaaata cagcttaatg 3532801 cagaatgggt tatcgcttac cgcaaagaca atcataatcc gcttataaag cattttattc 3532861 atatttcaaa ttgtcagcag acaagaacta aagagagtga tgcaggtaca tgaacaatac 3532921 ttgcaatctc ttttttcttt tgggattctt atggaatttt tattaattta atataatcgc 3532981 ttagtacaac tttatatcag tatacgtata catacagtac aaatagttgg caaggacatc 3533041 agtaagcgca ggacattagt ttgattttaa aaatgaaaga tagagaggtg aagtaaatta 3533101 ttgagttcac cggcatattc acattgctcg cttttttcgt aacaatgatt tttattttct 3533161 ggagaccaaa aggactaaat gaagctatcc ccgccacatt tggcgcttta atggttttat 3533221 tgtgcggaag tgtgtcattg gcagacttag gggaaatcgg aacaaaagtc acgggtgcat 3533281 cggttacaat ccttgccact atgattatgg ccattgcact agaaagcttt ggtttctttt 3533341 attgggtggc tgcaaaactg ctccaacaat ccaagggttc aggcatcaag cttttttggc 3533401 taaccaattt gctctgcttt ctcatgacca ttttccttaa taatgatggg agcattttga 3533461 tcacaactcc aatccttttg cttgtactaa aatatttagg tttaaaaaaa catcaaaaag 3533521 ccccatattt attaagcggt gttttaatag ccacagcctc tagcgcaccg attggcgtaa 3533581 gtaatattgt taatttaatt tctctcaaaa tcattggaat ggatctatat cttcacaccg 3533641 ccatgatgtt tgtccctagt atgatgggac tcatttttat gacttgtcta ctgtttatgt 3533701 tcttttataa acgtcttccc aaaagcctgc cagatatacc gggccatttt cagtctctgc 3533761 ggcatagaag gtaccatcct cttcattcgc catcagctcc tttaccagaa cgaaatcaaa 3533821 caaaaatcat gttgtttgtg cttgcatttg tttttctcgt cagaatgagt ctatttgcag 3533881 catcatatac cggtatttct gttcctctag tcgctgtcat cggatctttt atcctgttga 3533941 gctggagatg gatttatttc aaaacctccc caagagactt gttatataaa tcgccttggc 3534001 acatttttat attcgctttt actatgtatg tcttaattta tggtctgcat aatattggat 3534061 tcacagagtt acttgtgagt tattttgaac ctgtggtttc tggaagcctc gcccatgcaa 3534121 ctttcgcatc aggtatctct acttcagttt tttctaatct ctttaacaac catccagcgt 3534181 taatgatcag tacttttacc ttaactgaaa tgaccctgaa tccttcaaca acaaaaatca 3534241 tctacttggc aaatattatc ggcagtgata tcggttcatt attattacct atgggaacct 3534301 tagcaacgct tatttggatg catatattaa aacagcatga tgaaagtatt tcatggggcg 3534361 aatatataaa aacgaccatt atcatcattc cgctgactgt tctttttacg ttaacatgtt 3534421 tatatttttg gatcagttgg ttatttcttt agcacagtat gaaacgaaaa actgccttct 3534481 gcttttcaag agggcagttt tgtatacact agggaagatg cattgtcttt agatgattta 3534541 acttccaaat gactggctct ccacttgcgt taataagctc aatgatatta ttagagacac 3534601 cctttaatag tccgactttt tctggcacct ctcccatatc aaatatgacc aattcaccaa 3534661 tatttttttt gatctgctcc tcaaaattac gcacaagagg aactttggaa ggcacgaccg 3534721 gcaattgtga gttgtcaaga gtatacggtg tttgttcagt tgaataaggg gtaaaccatt 3534781 ttaaatgatg catagatata aaaagtattt taaatacggg tgagaaaaat acaatataat 3534841 cgtttaaaac atttgtaaca tatccatgga tcgatcgacc cccagttaca taaacttcaa 3534901 taaactggcc tttgaccttg tttaatgtat ttctatatga aaaagcttga gtttctgcct 3534961 ctatcattgg atcttccgga ttgatcaaaa atggcttctc agtactggtc actattttcg 3535021 ccttgtttat ttgatgaaga tgcaacaagg gaatataaag ataattgcag ccatcaaaaa 3535081 taacaaaaat atcctgtccg atatctatga gggtgccgac aaaccttgta tctcctgaaa 3535141 tgacaacctc aacatctgtg ttaaggaatt gattcaaacc tttcacgatt ctcctccttt 3535201 aactgaaaaa gggcatcact ttatctgatg ctcctccatt atctattaaa atttacgttt 3535261 ccagtgatag tctatcgttc tgacaatcgt ttcatagcta taatcttcct tttgttttcc 3535321 tgaacttttt attgaacttg aatagcctgg tgatcttgat gattgataat ctgaagatct 3535381 tggtgatcgt ttagatgatt ttgatgattg ataatctgaa gattttaatg atcgtttaga 3535441 tgattttgaa gaactttttg aacgtgacga acggccagat ttggatgatt gataatccga 3535501 agattttagt gatcgtttag atgattttga agaacttttt gaacgtgacg aacgaccaga 3535561 tttggatgat tgatcatctg aagattttag tgatcgttta gatgattttg atgagctata 3535621 tgattttgaa gaaatgaacg aattgctgtc cttatcatta ttgtcttcct ggttttgttc 3535681 atttttttga tcctcttttt tgtacgaccc ttttggacct aagctgatgc tttttatgtg 3535741 aaaaggatag atgcgaagca cctcttgatt tttcactata gtataatggc cgtcggcatt 3535801 atctacaagg ataccctcaa tggcttccgg acctccacga ttaattgaaa cccatttatg 3535861 agtcagactc ttaaaaacct cgcttaaatc atcagcttcc aaaactccaa ctggcgtctg 3535921 ctcttctatt ttcaaatcag gctcgtgttt acttatactt ttgatgtgat ggatattaaa 3535981 atacactacc ccatcctcat ttgtgtttaa cgcagcgtaa tcatctccca gccagaccaa 3536041 tcttcctttt ttagattccg gacccccttg gttaaattga actgattggt ttattaaatg 3536101 tccgattaag ctatgaaaat catcagcatc gagcatttcc tcagtctcaa ttgttgtggt 3536161 gctattattg gtatcctcag taatactttt cacatgctcc aactgataat aaattatttt 3536221 tttttcagct tgtaaagcta tataatctga ttttacagct gttaattttc cttttttaga 3536281 ttccggacct ccacgatata cagtaacaat tttatctttc attgagtgca aaaagttata 3536341 atacgatatt tcattatttg aatgatattt cattctcctc ttgctcattc aaattcctcc 3536401 tagtcactta tacatagatg ataaacatac tgcatatata cgtgtcacat ttatttgttg 3536461 aactaattca atagcctaat tgtcgctttt tccgcgaata cccattttca cgcattcata 3536521 aaatacttaa atgatctttg aggtattgtg aacggttttt aatatactcg cagatcacat 3536581 ccggctcacg gtcaaaacgc tcaatatcat tctttttata cgggtccatg aggacaaacg 3536641 gcctaatccg ttcatacatc gccatgattt tcggttccat atattctatt gtaaaaagag 3536701 attggagcgt tttttctaac aggcgcttgt aggacttgcg aaactcggat tcatccaata 3536761 tccgggcggt tagtgtatta aatccttgaa ttcttacata atcggcagcc atccgctctc 3536821 catggatatc cctgccccaa gtcgcatcat aatcccaagg aatcacctca aataatccgg 3536881 tttccccgct tctgtataat gcgtagttgt ggacaaaccc gtcatagttc gaggtgaata 3536941 caataccagc aagccagcgc aaatacttat cgacatccac gtgttttgtc acttctgact 3537001 taaactgagc tttagggacc gtattaattt taaaaatcat atcttgtaaa taaaaatcat 3537061 cttcctcagt ccctgttttc ttttcatatc caagctccag cgatgttttc gtttcccttt 3537121 ctaaatcgct catcagagaa aagttggcat catcatccac cgcataaaaa atcgcgccat 3537181 cagccagctt ccttttcgcc aaataatatt catctacgga ttcaagttca agataaaccc 3537241 cttcattctt cccattcatc tttacaaacg caaactctgc ctttggagac agtgtcccta 3537301 gctccgagaa aaaatccaga gacaatttgt ttctcatcaa ggaagggtct ttatactccg 3537361 catttaagtg aatctctcgc gcgccgcgga atgttttcgg ctgataaaag gaaatatggt 3537421 atgacttctt tttgaagtct ctgatatgtg atccccgata agcgatatca atatccagcc 3537481 ttttttgatt taccttcatc acagctggca ccggatcatc gtcccatata tcctttttta 3537541 attcacgcaa gtcttttgga tgaacaaaca gctgataaag cggtaaattg gattgattct 3537601 tcatccataa tcctccttac aaattttagg cttttatttt tataagatct cagcggaaca 3537661 cttatacact ttttaaaacc gcgcgtacta tgagggtagt aaggatcttc atccttaaca 3537721 tatttttaaa aggaggattt caaattgggc cactattccc attctgacat cgaagaagcg 3537781 gtgaaatccg caaaaaaaga aggtttaaag gattatttat accaagagcc tcatggaaaa 3537841 aaacgcagtc ataaaaagtc gcaccgcact cacaaaaaat ctcgcagcca taaaaaatca 3537901 tactgctctc acaaaaaatc tcgcagtcac aaaaaatcat tctgttctca caaaaaatct 3537961 cgcagccaca aaaaatcata ctgctctcac aagaaatctc gcagccacaa aaaatcgtac 3538021 cgttctcaca aaaaatctcg cagctataaa aaatcttacc gttcttacaa aaaatctcgt 3538081 agctataaaa aatcttgccg ttcttacaaa aaatctcgca gctacaaaaa gtcttactgt 3538141 tctcacaaga aaaaatctcg cagctataag aagtcatgcc gcacacacaa aaaatcttat 3538201 cgttcccata agaaatacta caaaaaaccg caccaccact gcgacgacta caaaagacac 3538261 gatgattatg acagcaaaaa agaatactgg aaagacggca attgctgggt agtcaaaaag 3538321 aaatacaaat aatctaagtt ttcattgttt caataggctg ccggcggagg tacggaagcc 3538381 tattttttta tttgccctgt attagatata tgtcatgaca taacatatgc aacccgcatc 3538441 atttggtttc ctttaaacca tttcgttata atcaaggtat cctaacgata aaggcggttg 3538501 ttgctatgta catatttcaa gctgatcagc ttagtgccaa agacacatac aagctattgt 3538561 caggtaccgt tattccccgc cccattgcat ttgtgacaac actttcttca ggaggagcgg 3538621 taaatgccgc gcctttcagt ttttataacg tcgtcagctc agatcctccg cttctcagta 3538681 tttctgttaa caggacggaa ggacgccaaa aagatacagc acgaaacgca gtggagaacg 3538741 gagaatttgt cgttcatgtc agtgatgaag ccatcattga agatatcaat gaaacagctg 3538801 caagcttaag gccggatgaa agcgagctta cacgcacctc gcttcatcct gttgaaagca 3538861 aagctgtttc agttcccggc attaaggaag cccgcgttcg ctttgagtgc aaattagagc 3538921 ggcatattac ctttgacaat gatcaaggca tcactacagc agatctgctc atcggaagag 3538981 ttgtctgctt ccacctagat gaaaaggtgt atgatgcaga aaagggatat attttaacgg 3539041 atgaattaaa gcctgcctca cgattggcgg gaaatcacta tgccaagctg ggggaagaat 3539101 tcacactgat tcgtcccagc tgaagagaag gactatttaa atagaagaaa ctagtcaaaa 3539161 agaccttatg attacaaaat atcgcctgta aataactgaa aaaatatcaa aaaaaagaac 3539221 acccagagca agctcggggt gttcttttat gaaacgtttt tcctttttct tcgtataaag 3539281 gtagattagg aggaattgga atgacaaact tttggatttt aatgctgatc gctattacca 3539341 tcagtctcgc ctctcaattt tttataaaga aaaaatacgg tattgataaa tccggctggc 3539401 gatataagca tgtcagcaat acacacaaat ggatcgaaat cactttactt attttgtttg 3539461 tgttttcact ctcctttttt ccagttgaat atttgcttct tttatttttt attgtgattg 3539521 actcaatacg tatttttatg gagtggcatt atagacctga agataaacag tatatgtacc 3539581 acattgtaga ggtctccctt atgtttatgc ttttgattta tgtttgtacc ctatagttat 3539641 ttaaatcccc acagccgctc cgtctccccg aggatcggct ccgccttgga gaaagccttc 3539701 ttcatcaact ttgattgcag ccgcttgtcc catcagcgga tcatagtcac cgacaacctc 3539761 cacgagatgc ccgctgtctt tcagtttttg gattgttttg tctgtgaatc tgccctcgac 3539821 tctgagacct tcgtattcct ctccccacgt tctgccccat acccagcgcg gttcgctgat 3539881 tgcctgctgt ggatgcattc cgtagtccag cattcgggta atgatggccg tctgggtctg 3539941 cggctggcct tcgccgcctt gtgtgccgta cagaattttt ggctttccgc ctttacagac 3540001 catagccggc atcaacgtat ggaaggtgcg ctttctcggt tcaagcgtgt tgacatgatt 3540061 ttcatccagt gagaaaaacg atccgcggtt ttgcagtaat atgcctgtat caccggcagt 3540121 gactgccgag ccaaattcaa agtacaggct ttgaatgaat gacactgcgt tgccatccgc 3540181 atcgattacg gccgcatatg ccgtatcact tcccaccggc ctgctttctg ccggtattgc 3540241 gagatagccg atttcttctg ccaattgttt tgcataacgt ttgtccaaaa gcctttcaag 3540301 cggaatgtct gcaaacgccg gatcagtcag gacggcatcc cgatctagaa aactcttttt 3540361 caatgcctcc acaagcacgt gataatactc aaatgaaccg tgttcgattt gggtgaaatc 3540421 atagttttcc aaaatgttca gtgttaataa accggtaaat ccctgagaat tcggcggcgc 3540481 ctgatacaca ctgtatcctc gataatcact tgatacaggc gctgcccact caccccgatg 3540541 cgctttaaaa tcatcgattg tcatgtaact gccgttattc tgtaaatgtg agacaatccg 3540601 ctgagcgaga tctccttcat aaaatgcgct tcttcctttt tcagcaatca agttcagact 3540661 gtctgcaagc tctttttgca caaaccgctc tcccgggaca ggtgctttgc cccttctcgt 3540721 gaagatgtca gccgtgtaag gcgtggaagc cagcagttca atattctttt ctgtgtgacg 3540781 acactgatca gctgatacag gaaacccatt ttgggcataa tcgcgtgcgg gctccaatac 3540841 atctgcaaga gacagacgcc cgtactcctt caggaccgca tcccagctat caaccattcc 3540901 cggcacggta atagcactgt caattccccg cagcggaatc gcgctttttc ccttatatac 3540961 atctctcgtt acgttttttc ctgaacggcc gctgccattg tagactttta ctgcctttgt 3541021 ttcctggtga aaggtcagcc aaaaggaatc cccgccaagt ccggtcatat gcgggtacac 3541081 aaccgcaaga caagcactca ccgcaacagc ggcgtcaaac gcgttgcctc ccttatccag 3541141 tatgcggttt ccggcttgag aagcgagata atgcggactg acgaccattt gctttgtacc 3541201 gatgacagat ttgttcatca caagtcccct tttttaagaa attttcttca gtatagggag 3541261 cctgattttt cacatctact gatccggcag aaaaactgac gaactttctt cttttcgcaa 3541321 ataataagat attttcgcat tcatttcgaa aacaaatgaa aaattattat ttctatacgt 3541381 aacttttatg ataaaatgat tgctaaaagg ctacgaaagc aggtggagca attgagtcat 3541441 gaatatcaaa tccccaacct tgtacttgat gagactgata aacaaattct cacgattttg 3541501 catgaagaag gcagaatttc ttatacggat cttggcaaaa gagtcgattt gtcacgggtc 3541561 gccgttcagg cccgtatcaa ccaattaatt gaagccggtg ttattgaaaa attcaccgct 3541621 gtcatcaatc ccgctaaaat cggcatccat gtttccgtgt ttttcaatgt cgaggtagaa 3541681 ccgcaatttt tagaagaggt cgctcttaag cttgaggaag agcctgcggt caccagcctt 3541741 tatcacatga caggcccgag caagctgcat atgcatggga tctttaccaa cgatcaagaa 3541801 atggaagaat tcttaacaaa acggctgtat ccattgcgag gcgtcgtcag tgttgattgc 3541861 cagatgctga tcaaacgata caaaagccgt atgggaatga agctgtaaag gagagaaaca 3541921 aatgaaaaac catccttatc gggatatgac ggccgcaatg gttcgcaccg gcatattagg 3541981 gttcggcggc ggaccttccg tgattccgct gatccgccat gaagcggtca ataaatataa 3542041 atggattgac gatgatgaat tcggagaaat attagcaatc gctaatgcgc ttcccggacc 3542101 gattgccacc aaaatggctg cttatctggg ctttaagcta aaaggcacat taggtgcaat 3542161 tgtggcgatc ctcgcccaca ttctgcctac atgtcttgcg atggtgggct tgtttgcggc 3542221 tgtaaatgtg ttaagccatt cagcaattgt tgcaggtatg attggtgccg tcacgccggt 3542281 aattgcggtc atgctcggaa tcatggcgta cgagtttggc caaaaagcgc ttaaaggttt 3542341 cggctgggtt accggcatcc tgttttttat catcgctttt atcggcctgc aaactttaca 3542401 gattaatccc ggcctggtca ttatcatttt cttagcttac ggggcgtttc attttaaact 3542461 gaaagacaaa atcacaaata aacattcaaa agataaagga atgtcagcct catgatatcg 3542521 atctatttat ttatggcgtt ttttatcgca aacctactgg gatatggcgg cggacctgcg 3542581 tctatcccgc taatgtttga agaagtcgta aacagataca gctggctctc aaacgatcaa 3542641 ttctcaaata tgctcgcact tgcgaacgca ttgccgggcc cgatcgccac gaaaatcgct 3542701 gcgtatgtcg gctacagcgc aggcgggtgg cccggcttcc taattgccct gatcgcaacc 3542761 gtcgtaccgt cggcgctcgc attgatcgtc ctgctgcgca tcatccagcg cttccgccaa 3542821 tcacctgtca tcaaaggcat gacgctgtcc gtccagcctg tcatcgcggt catgatgctc 3542881 attcttacct ggcaaatcgg cgcagacggc atcaaagcga tcggctgggt ccaatcgatc 3542941 gtgattacgg gaatttcgct ccttgccatg acaaaattca aaatgcatcc ggcatttttg 3543001 attattgcgg cgtttttata tgggggcctt gtgatccctt atttatagaa aaaagcacct 3543061 ggacaggtgc ttttttattt tagcccagaa atgccgtttg atatgacagc tgtttcttct 3543121 cctgcgtcac tcttgatcat gtgcttgact tgcagcgtgg ttcctgccat tctcacagat 3543181 tgcttcaact gggacgaatt ggtttcaact tgtatccaaa caggaggctg gaccttccaa 3543241 aataaataga gtgcaagaat cagcaagcca gcaatgaccg acagcaaaaa cttcatatcg 3543301 catcgcttct tttcagtaag cggctcgcag cggacagcgc ctgatgatca cgaagaatat 3543361 cgcctggacg attgccttct cccagcacat agcctttaaa ggacattccc ataaaatgaa 3543421 aaatatgttc gaattgctga atcagcggca gcccttttat ttttggattg tctccgccca 3543481 ctgctattac atatgcctgt ttcactgaca tttgctgttt aaaatcagga aatctcggat 3543541 ctctcaacgt ctgtgaccag cgatcaataa acagctttaa tgtccctgac atgccaaacc 3543601 aataaattgg ggtggcgaat ataagaatat ggcactgcaa tatccgttca atgatagaat 3543661 cgtagtcatc ttgaacagga cgaaagccgc cttgggcgtg acgcagatct tcaattggtt 3543721 gaattggata tttctgcaaa taaatgtgct ccgcatcgaa tccttgaaca gccttctccg 3543781 caagaacatc cgtatttccg ccagaccgag ttccgccgtt aataaccgca attttcatga 3543841 tgcatctgct cctttgttta cgaatgattt tcttcatcat ataatggatt catcaatcaa 3543901 tacagatgat tatttcgatt aatccaatcg ctaaaaccga tttagaaagg aagagaacaa 3543961 gtggaattga agcagctgat cacctttatt acggcggctg aacatgtaaa cttcacccta 3544021 accgccaaaa tgcttaatta tgcacaatca agcgttacct ctcagatcaa atcacttgaa 3544081 gaagaaatcg gaacgccttt atttgaacgg ctcggcaagc ggcttatctt gacagaagca 3544141 ggaaaaacgt tcaaatctta tgcacagaag atcattgcgt taacagaaga agcgaaaatg 3544201 gccacaaatc aagtaagaga aacaaccgga accttaaaaa tcggggcgac ggaaagccag 3544261 tgcacatacc gcctgccccc tatcataaaa gaatttaaac aggcttttcc ccaagtaaag 3544321 ctcatattca aaccatatat ctccaatgaa caagcgaaag aacagctctt acagggccag 3544381 cttgatatca ccttcatctt ggatgtaaac cggatggaag acgcactgca cgttgaatct 3544441 ttgattcagg atgagatcaa aatggtggct gctaatgacc atccttttcc tgcggattta 3544501 ccagtaacat tgaaggatct tcaaaacgaa actcttctgc tgacagagga cggctgctcg 3544561 taccgcacgc tctttgagaa caatttgcat gactccggta tctatcctaa caaattggaa 3544621 ttcgtcagca tagaagccat caaacaatgc gtgatggccg gacttgggat tggaatcttg 3544681 cctgaaatga cagtaaaaga tgatattgca gcaggccgga tgaaagaact caattggcag 3544741 agcgattgcc ccgttttcac tcaattagca tggcataagg acaagtggat gtctgcgcca 3544801 ttaaaggctt ttatcgattt gacacggaaa acattcaaat aaaacctctc cacaaggacg 3544861 acaaggtttt tgagaccagg gcacacacat acaaaaaaaa cacttgatga cttagagccc 3544921 caagtgttac acgtgatttt tctgataaaa cgttcgcaaa acatgcgtct caaggtcagc 3544981 caggcggaca gggatcggca gcctgctttc ttgattgatc aagctcatcg tgatctgata 3545041 gctgctgtct aaatcaatat aattaccgca agacaagaaa ataggcttca cgtcccgccg 3545101 cgttcgcagc gcccgtccat atacctcgcc gtcaatgata atatcggtgt atgcgcctac 3545161 ttcaatttca ggcgtcacga aatcgcagcc tttgattttg agataggttt tcgctatccc 3545221 aatcgtcggc ttgcccagaa aaaaagccgc atgggtggca acgcccatat gattgtaatg 3545281 cagatatccg ttgccatcaa acaagaagac atccggctcc gtctccagct ttttcgccgc 3545341 ctcgatgatc aagggcagct cgcgaaacgc aagaaaaccg gaaacatacg gcacgctgat 3545401 tctccccatg ctgtgcactt tttcaatgac ttcttttgta tcagcgtcaa ttacgataat 3545461 acagcacact ccgtatggtt ctccatcctg ctcccaatag gccaggtcga cgcctgcgca 3545521 ggtgttgatg gagtctggat ggatcgtggg ggataggttg atacgatttt taaggttaaa 3545581 ttgcacttgt aaaaagtctt gttccttttt catatcaaat ttatgcacat caaatacctt 3545641 cataacgatt gctcactctc gacctaaatt aatgtgagtc tctcttctcg attctagtat 3545701 ttcaaaatga ggactatctg tatctatctc gtacttattt aatagattgc cttcttcatc 3545761 ccaattcttt tcagaaatta gtatggaatg ctcatactgt tgctcacttt ttttcctgcc 3545821 attttcaaac caaattatgc ttataccgtg caattgccca tatcggtatt ctttttcact 3545881 ttttttattc ccgttttcat aaaattcaca tgttaaacca tgggccagac cattcttata 3545941 tttagtaaaa tagatgattt gaccatttgg atataattcg taagccagcc ctgtaaacgg 3546001 ctggccattt tcgtcttcag gattatctaa aatctcatca cttaccgaag agaaccataa 3546061 atcctcaaag tccactccct tttcttttat actcttcata tcatattcat tttccatact 3546121 ttaaagcctc cggtatataa tttgtatttt gagttatata ttcacaatgt ggacatctag 3546181 gcattgggac accttctggc atctttttat ttattttcct agcacttact acatatacca 3546241 ttaaatcttt taaatccgca tcaggtcttt gaagtaacgc ttcatttaga gcattaactt 3546301 cggcatgaga acccgcccct gacgtcttta tataaccttc tttaagttct gtaggcatat 3546361 ttacaattct atcatgaata agtggatgta gtaccttagg tggcttccca tctatattgt 3546421 ttattccaaa ataataattg cctgtttttt tgtccaatac accagctacc gcagggcctc 3546481 tttgtttttt agttagacca gaagatttaa ttctactaag ttcgtttagt acttctgccc 3546541 ttagatttat tcgatggtga agatcttctt tagacaatac accatgctta tttcttaaat 3546601 attgaagcct agtttgtttt tcttcagtag tcttagcaat attgctaata aggctttcat 3546661 tactcacttt attgacatat ggagcatttt tttggtacaa ccgatcaaag tagtgtgcca 3546721 atcctgctcc accaataata gtaatagctt ccagcgcccc ttgcttccgc ttctcctcag 3546781 acactttgtt tccgaacata tcccggcctg tgacagcttc tgagaatccg tttgacgcaa 3546841 caaggccgta tgcgcccatt tctgtcattt tgagaatgtc taaggatttg cctgttttgt 3546901 aggcgtctaa tgcgtgttca gcagcgatag ctgcttttcc ggttttgtag atggcttttc 3546961 cgcctttgaa ggcccggcct gcccagccga cgactggtat gaatccggca gcggccatag 3547021 ctcctgctgt cacacgctcc gcggtggaga gtttttctcc ggtaaccgga tcaacgcctt 3547081 cggttgctct tttataatca taatagccag tgacttctcc agtaaagttg caaactccat 3547141 cccatgtttt ttcgtaccac ggtttgtttg cttcttcctc ggctttttcc tggagccgtc 3547201 ttgcttctgc ttgctgggtt tttgcatcga tataggttgt tccttgattt tctacttcaa 3547261 tgacgctttt gtagacttca ttgctgtgga aggctttttt gtcatagtac ataggggatg 3547321 cgctcttccc attgctggtg gcctgcatga gaacagaata tttggtgagc actgcgttgt 3547381 ccagagattc taaattttga tattcagtgg tcagggattc atcaagctta tcgacagctg 3547441 tgattgtatc acgtctgatt ttttgggcat cgcccatctt atctgcatag tcgtcaagcg 3547501 tgtacatgtc gagatcaata atatcgctga tgcctgacaa aatagaatcg atttcttctt 3547561 tatgagcgga gacaatctct gaggctttca ggtctccatt gggcagctca tgatccaaaa 3547621 aagaagtttc cacatatgaa tcattcagtt cttgatcttt aatatctcct gaaatgccgt 3547681 ttaaaaacgc aatttgagca gagacaagcg tcagccagct gtctacgatt tctgcctgtc 3547741 cctgaaaaaa atctttaata ttgtccgcgc catttccttt aaaattatcg cctaaatcgg 3547801 caactccctg aaacgctttt ttcagcgtat tcagctgctc ttcaagcgtc tcatattgct 3547861 tttttctgct cttcgcttct tcgattaaag attttgattc aaatacttta ctcatcgcac 3547921 tgccctttct gttctatttt accgctatcg cctcgtcctg ctctttgagt gaatctacgt 3547981 tatcctttgt atcctcgata tttttctgta ccgctttttt gtaatctccg agcatggttt 3548041 tgatgttctc ctcacgctca tggtattttt tcgtataatc gaggctgttt tttccgttgg 3548101 atcctgcggc gccgattgat acgtcagcaa gcgcatcttt gacagaatct aatgttttga 3548161 tgactgtgtc gtacttcagc ttaatttctg acataaaaaa agatcaccac cattttagtt 3548221 tactaattgt atttccgact tcttccgcga actcttctcc ctttttaaga agatctgctg 3548281 caccatttgc tatgaacaat tccgatgcat atttagcttt atcccattca agatcaaaaa 3548341 ttttcccgtt aatcgaagcc atatactcgt tatatttatc attcacaatc ttagatgctt 3548401 ccgatttcgc ctcttctctt cccttgtcga aatcatcggc ttttgttccc gtccaatgct 3548461 tgcccaattc cggtttcaca atttctttga tttcagtgat tgcctcttct tgcagtgtgt 3548521 ctatgtcctt ttttgctttt ttcagctttt cgatcttgtc ttccacgtct gaaatttttc 3548581 cgttgagcga acttttgata tccgctagca tactttcata acccatctga atcacctctt 3548641 aatactcaaa aagtcgtatg gaggggctga tgaagataga cttttccata ctttatttcc 3548701 atatattata ttttaaaata gccagaaggc ggcttaaata gggtaaatgg cttaatttag 3548761 gcatataacg ctcttgaaat gtaggtattt gatcttgttt ttgttcgtta tacagctaat 3548821 aaaagcgttt tataaaatga aatcacctaa tgtcatagtt ataaaggcac ttgaaagagg 3548881 cagatgttgt tgatctgcct ctttcggcgc tgagcttatt gttcatgttt atgttcttca 3548941 tctggtcggc catgtctgat tttgtcattt ggcttctatt attcccccct tctgaccctt 3549001 tggatcaaaa gcttgtatta gctgcagtcc cagttgtaca gaacgtttga aaagtctttt 3549061 ttccttagat cttcaggtgt gatgaaaaaa ttggcgatgc cgacgtctcc ccacattgaa 3549121 tcgatatcat cgtctgaatc aatttgtaac agcatgatgg tgtgttcttt atatgcgtat 3549181 tcccggggat catgctgggt aaaagaagcg tatccgccaa ttttatggcc aaatccgttt 3549241 tcagccagtt cattataaat gtcttcttca tcctcgccga actgaccaaa gaactccatt 3549301 gtttccatgc ccgtatactg ctcaaattga aaatctgtag gcagcaccca ttccgaagat 3549361 ttcacaggct cgactgccgc ttctgataaa atcggaaaat cacattcgcc tgtgccaata 3549421 aatgaaaaat cagaaacaag ctcgtcatcg ttttctacga tattttcaaa atagatcact 3549481 ctgaaattct tttgttcaca tcgatcgtca aaattcaatc catagacgtc atcatgaaca 3549541 gaaatgtaga actgcaggat acctgaagaa gggtagccgt caagctgggg aatgtgcgag 3549601 aaattaatct gcgccagaag tttcatcggc tgtccatttt cgtcagtcgg atatgtttca 3549661 tgcttgggga aatagggatc accggcaatt ttgctgtcat atcgtcctgt tttccccttt 3549721 ctcacattca gtttcacgta ttctttcgct gatttctcca gcaagtcgcg gtacggtctc 3549781 attttttcgg gcagatgatt catcagattc tctccttttc cggcatctcc aaggttttat 3549841 tttctggttt tcttctaatg tttttcaaac gaatgtttaa agaagcccta cttctgcata 3549901 attttccaaa caatagttaa atagtagcaa atgtattcag caccccgcaa tagatgaaaa 3549961 aaagactggt gcgcaaccag cctttctttt tcatctattg aattgcacct gacggaacaa 3550021 ccgccttccg tccgacagaa taatactcca ctcctgcagc caaagcctca tccaatgtgt 3550081 agcagtttct gccgtcaaat atgagcggcg tttccatcaa atcctgataa gccgctaacg 3550141 ggaattgttt aatgtcagcc cagtcggtta aaatcatgac ggcgtcagac cctttgacag 3550201 cttcctcgat cgtctcttta tattcaacag cttgcgggag aacatgcttt gcatggctaa 3550261 ctgcaatggg atcgtaggct ctgatacggg cgtcgagcgc agcgagacgg tctgcaataa 3550321 caattgacgg cgcttctctc atatcgtcgg tattcggttt aaatgacagg cctaaaaggg 3550381 caatcgtttt tcccgtcacc ccaccgagcc tgttcagcgc tttatcaacc agcatcgcct 3550441 gctgattgtt gttgactttg ataacggatt tcagcagttc aaaatcatgc tcgacattgc 3550501 cggcaatttg cacgagggcg tttgtgtcct ttggaaaaca agagccgccg tagcctatgc 3550561 ccgcttttaa aaactggctc ccgatccgct tatcctgtcc catcccgtat gcgactgctt 3550621 caatatcggc gccgaccttt tcacatatat tcgaaatttc gtttataaaa ctgatcttag 3550681 tggccagaaa agcatttgag gcatatttga tcatctcggc gcttctgata tccgtttggt 3550741 aaatcgggat ttgaaacgga cggaagagct cctccagcgt atttgctgtt ttctcatcgg 3550801 ccgtcccgat cacgatcctg tcaccatgaa aggtatcata gatcgccgac ccctcacgca 3550861 aaaattccgg attggatgcg accgaaatac tgacaggctc cgctagatgt tcagtaatca 3550921 gtccattaat caaatcgttt gtcccaacgg gcactgtgct tttcgttacc acgactgtat 3550981 ctcgtttgac atgctttgcg atgcgtttgg ccgcatctgt aatttgctcc agattggcgt 3551041 gcccgtcgct tttctgcggt gtgccgaccg ctataaaaat gatgtctgcc tgtgccaagc 3551101 ctttctcata gctcgtttca aagttcagcc gtccatcagc tgtatttttt ctcatcagct 3551161 cttcaagacc tggttcaaat atgggggaaa tgccctttct catttcatca atcttgtgag 3551221 cgtcaatatc aatgcaggtt acatgatgtc caatctcaga aagagaaaca cctgtcacaa 3551281 gaccgacata gcctgttccg atgactgtta tattcattgt ttccctccaa cagttaaatt 3551341 gctgctttgc agcttccgta atatcgtatg agaacatcct atcatgaatg cgaatgatct 3551401 cccgcatagc ctgtcgggta cagcctgtac agatttctga aatgtgattc aaccatacaa 3551461 tacactatta tatcgctctc aaaaagaaag tggtgaaatg agaatcggct gttaaaaaaa 3551521 accaaacaat tttcttcttt tgaccggctg cggaggctgt ctgaagatgg tctgattccg 3551581 caggagaagc tctgcatttt ccgtcagcat ataaggaagt tccgagccga attctttctc 3551641 tagaacataa agagcctctt gagtgtgaaa atttctcgtt ttcacattat gggcatctga 3551701 ggctacgaaa tggatcaaat tggcttcaac cagccggaga gaaaatgctt tcagctgctt 3551761 gccgaagatc cccgcaagac ttcctgaagt aatctgagat gctgctcctt tttccacaag 3551821 atgatacagc aaggacgggt tttcgcgaat ttccctgttg cgttcaggat gggcgataac 3551881 cggaatatat cctttcagct gcaaatcata aaaaagctgc tccgcatatc ggggaacgtg 3551941 atcaaacgga aactcaatca agatgtattt tgtatcattc agcgaaagca gctgacgttt 3552001 ggcaaggtct tgttccacct cgccgtagat tctgatttcc tgtcccggaa gcacatgtaa 3552061 aggaatgtct tctttgatta aacgtttgtt taactgatct gctgcttctc tgactgcggc 3552121 tggctcgttt ttatacacac cgttgttatg atgaggtgtc gcaatgatcg tccggattcc 3552181 ctgacgaaca gctgctcttg ccatttctat gctgtcggcc gaatcacctg ccccgtcatc 3552241 cattgcggga agaatgtgac agtgaatatc gatcatgtcc tagccccctt ttttcgcaaa 3552301 aataaataac gggcacgatg cacgttattt atttttgcat gaaattgtcc ttggttccgt 3552361 aatatccgta ttcagagtgc ttcgaaagct ttttgccgtt cataatcgcc ccaaggagct 3552421 tgcttttgca cgttgcaagc gcctctttcg cttttgcggc ttgttctttt tctgttttcc 3552481 cgcttgaaat aaccagaaca gaaccgtctg ccacgttgcc taaaatctgt gcatctgcta 3552541 cggcaagaat aggcggcgta tcaaaaatga ccatatcata tgccgcacac gcttcgtatg 3552601 caagctcctt catccacttc gaggagagaa gctcggccgg gtttggcggg atcgggccgc 3552661 tcgtcagcac gtcaagatgt ttttcattcg atgcttgtac agcctgctcc atagagcttt 3552721 tctttaataa aacagatgtt aagccaaccg tattttcaag aaaaaaagcc gtatgtactg 3552781 ttggttttcg caaatcagca tcaatcagga gcactttttt tccctgttgg gcgaatacga 3552841 cagccaggtt ggcggccgtt gttgattttc cttcccccgg acaagccgat gtaatcatga 3552901 ctgatttcat ttgccggtcc actgaagcaa attctatatt cgtgcgaatc gtccgatatt 3552961 gttcagagtt caaggatttc ggctctgtca ttgcaatgac atttctctgc atccgcgagc 3553021 ctctgttttt tctaagcgcc aaaatgtcca ctccccgttt tttcagattg gaaaccctgt 3553081 aaggtctttg ctgttttctg ctcattcgca atggtggaaa ctgtccctaa aacaggtatg 3553141 tccagcaagg attcgagctg ctcttccgat ttgatcgtat tatccaaatg ctcaagcagg 3553201 aaggccagtc cgatgcttcc cgccaatccg gccgcaaacg cgatggcaat gtttagtagc 3553261 ggctttggcg atacagggga cgggtgttct gaaacctcgg cttttgacag aatgctgaca 3553321 ttgtcaacat tcataatgga tgtgattttg tcttgaaaaa cagatgctat agtattggca 3553381 atatgagccg ctgtttccgc gttttcatcc ctgactgata tgttgaccac ttgggagtcc 3553441 tgttcgctgg atacggtaat tttgtcattc agttcttggg atgtcatcga caggcccatt 3553501 tctttaatga cttcatctaa gatggcaggg ctcttaatga tgacattgta cgtattgatt 3553561 aactgaagat tggtttggac atcgttaaat tggacttctt ttcgttcatt tttcgattgg 3553621 ttgaccagaa tctgagttga attttcatag atgggtgtaa gtgcgaagaa actaatgagt 3553681 ccgccggcag cagtggcagc cgcggttaca atcataatca aaagtatgcg ttttgttaac 3553741 gttgataata tctcttttaa gcttgtagat tctcccatga tacctccaaa tctcttataa 3553801 catccttttc catctacgat tatacaacgt tgaaaccgca tttctccagc ttttcacgtg 3553861 acataattcg acattttttt acaatgcgtt atgttagtac tttttatgta agcgctatat 3553921 ttactgtgtt gacagtgctg tctcattttc tcttattcgg gcagtcacgt tctctcgcat 3553981 aaaaaaatcc cgctaaaggc gtgcgggatt tttatgttgc atatccattt ttaatatgag 3554041 aaatcaaatt ttcaagcatt tccttcgtcg tcatctcaga tgactgctca ccaatttcat 3554101 gtgcatgcat caaaattttc agaaattctt cttgattcaa tttcttttca ctcatctttt 3554161 ttttcctttc agcttccatt aagttgaaaa cacgattatt atatgatgct ggttatcaat 3554221 ttgcaatctc taatacatca ttcgacacat cctatttttt atgtcctttt ttaggaaaaa 3554281 ctttttaagg ccgatgtgtt gcgatataat agagaaattg gatcttttta ttacgtgact 3554341 cggttaggag cgataatcat gcttcagaat atgatttcca aagacgatgt gctggcatct 3554401 gctgaacagt taaaagaact tcttccttac aatgaggaaa atgttcagct gatcaaaaaa 3554461 gcccttattt tatatcggca ggattcagtc tatcgtttac aagcagtgag tccgacggaa 3554521 gttacggctt acgtgcagga tgttgtgcct gtgcgggtca cattgaactt gtttgtcata 3554581 gtcaaaagcg gctgttcatg tccgtccgga agaatctgcc gccatatgct ggctgtgttt 3554641 ttatatgtat atgcaatgtt cgagcgagtg ggtactttta cagagtattg gctggagagg 3554701 gaaaagcttg aggaaagcaa agagctcgtc cgccgccagt ttcaggaaaa ggtgctgcct 3554761 aatgaagaat cactttcaag ctggcttgct ttttttgatt cagagttttc tctctggcag 3554821 gcacgtacgc cagaaggcag ccaaaacatg cagggcctct attacggcta cctgtccgca 3554881 ttaaaaaaac atgcgccgaa caagccggag ctgaaaagcc tgtatcagat tcattccgcg 3554941 attgcggttt ggcttcgcat gttcacattg attgaagcgg gcaagctaaa ccccgaacaa 3555001 gatttttatt ccctcaatcc gtacgttgaa cagctgatgg atacaatcta cagctctatt 3555061 gataaattaa aaacgtacgc gctgtctttt gcgcttgatc cgtttttgga taaaacaccg 3555121 gatgttatcc ggcatttgct gttgaaagaa gaaattttcc aatatgaacg catccgcgtc 3555181 ttcggtgaaa tttggagtgc gctgctgtcg cggccaaaat gggtggcacg cgaacaggag 3555241 atattgaaaa aagaagcagg acggcgtttt tctcccgaat tgcaattcgg gcgcctgcat 3555301 ttggaattcc tgcaaaaaaa tgatgacgtt atttttgagg aagcggatca attcccgccg 3555361 gaagcgctcc cttatacatt ccaatggctg agtgaaatga ctgccaagaa ggactggaaa 3555421 cggcttaaaa catggtacca gcaaattgaa ccaattgcga tgggttatac gaagctggat 3555481 aagccgttta aagagattcg cgatgtgatc ggcgagctgt tccttctgtt gaatgcctat 3555541 gtgcagcaaa ccaatgatca agcgctgttt gagcgctttg ccgcgggctg tctgccgtat 3555601 acgttcacag aatacagcca tcatttatat gaaaaaaaac gctatgccga gtggattgaa 3555661 attcatagcc ttgtcggctt ttccatcaat gaaatggata aaatgatgct caaggaaatt 3555721 gcagcgagcg accctgaggc gcttataccg gcttaccata gagaagtggc ttttttcatt 3555781 gatcagaaga accgtagctc gtacaaggaa gccgcccggt atttgaaaaa attgcgcacc 3555841 ctgtacaaaa aagcgaaaaa gcagaaggtg tgggagcggt atattcagct gctgagctcg 3555901 cattacaagc gcctgcgtgc gcttcaagaa gaactgcaga aaggaaagtt gattgatggc 3555961 gagtcttaaa gaaattctca tccacgtcga acaaatggaa gatgggtcat ttacgctctc 3556021 agcctttgat gagaatgagc agcctcttcc ctacagccat atgaaaaagc atttgttcca 3556081 atggcatgaa tcctcatttt acggaacctt tctagaggat gtcagcttca tcgggacgac 3556141 tgctgtcctt ctatctccat ggatgactgt agagcttctc ggcaaaaact cgttcaactc 3556201 attcagctcc gtgcagctta cagaagaaac ggagccgctg atcgaggcgg catcgaccat 3556261 ctatgaattt atcgcggacg gcgattttat gcctgactat gacgcatgga caaacggtgt 3556321 ttttcgctgg aaggaccgcg ataatatact ggaaggcttt actgcggaat ggttttccgc 3556381 tgccgtacag gattacatcc agtacgacga tgacctgcgg gagaaatggg aacatatcaa 3556441 ggaaaaatcg cctgcggtta cgacattccg tggccatttt cttgatgaag aggattttct 3556501 ggaaggcatt ggctggattg acgatcaatc tccatttact gtcggcttgc gcttaaatga 3556561 accggacttt gacggagacg aatggaagat cgagatgttt ttacgcgata aaaagagcgg 3556621 tgctgtagaa ttctttgacg gactgaagag cctcaaaaaa tcgtggcagg cgtacagcga 3556681 taaaatcgcg cgtgagcagg accgctttca cagaacggtt ccgtggctgt cgtttgattc 3556741 cgggacaacg ctgatctcgg aggaagaagc ctggatcttc ctgtcagaag caagtgagac 3556801 gcttgtcgat atgggggtag aaatcctcct gccgtcctgg tggcagattg tcagagacag 3556861 caacatgatg ctgaaagcaa aggtgtcttc ctccccgcgc ggcgagtcat ttgtcggcat 3556921 gaatgcactg cttgatttca actggcggtt tgcgacaaat ggaattgaac tgactgaggc 3556981 tgaatttaat gagcttgtcg ccagcaacag gcgccttgtt aatatccgcg ggcaatgggt 3557041 taaaatcgat ccgcagttta tcaaacagat gaaacgcctg atggaaaaag cagaatcaga 3557101 gggactccac atgtctgata ttctggcgcg ggagctaatg gatcagcagg atggcggact 3557161 tgaggattcg gacctgattg atacatctgc ttttgccggc attcagtttg atctgtctaa 3557221 acagctcagg tcactgattc gaaagctcac tgccgcggaa aacctgccgg agcacaaagt 3557281 cagtccttct ttcaaaggaa cgctccgccc ttatcagaaa tacggcatga actggctgct 3557341 gtttctgcgg gaaagcggtt ttggcgcctg tctggctgac gatatggggc ttgggaaaac 3557401 gattcaaatg atcgcctatt tccttcacgt gaaggaaagc ggccgacaaa aaacgcctca 3557461 tttgattatt gcgccgacat ccgtacttgg caactggcag cgggagcttc aaacctttgc 3557521 ccctgatctg tctgtcgcgc tccattatgg gccgcgccgg ccaaagggtg atgatttcgc 3557581 cgcgcattat gaaaacgcag acgtggtgct cacttcatac ggtctgtcac atgccgatac 3557641 tgaagagctt tcttctgtga catggaacac gatctgcctt gatgaagcgc aaaatattaa 3557701 aaacgcgcat acgaagcaat cacgcgcaat caggaagctg aaggggcttc accatatcgc 3557761 gctgagcggc acgccgatgg aaaaccgact gactgagctg tggtctattt ttgacttcat 3557821 gaataaaggc tacctcggca gtttgaccgg cttccataaa cgctatgtgc tgccgatcga 3557881 aaaagaccgg gacgaaaaga gaatcggaca gcttcagcaa ttaatccggc cattccttct 3557941 ccgccggacg aaacgggatg aagaggtcgc gcttaatctt cctgagaagc tggaagaaaa 3558001 agaatttatc cctctgtcag ccgagcaggc atccctttat gagcagctcg tcaaagacac 3558061 ttttgaccat atgacatccc tgaccggcat gcagcgaaaa gcgctgatcc tcagcatgct 3558121 tggacggctc aagcaaatat gcgatcatcc cgcgctttat ttaaaggaag agcaaaccga 3558181 gctgctggcc ggcagatcag tcaagctcga aaaattgctg gaactgatga cagcgatccg 3558241 cgcccaaaac gaaagctgcc tgattttcac gcaatacatt cagatgggga acatgatgaa 3558301 gcggctgctt gaaaaaacgt tcggggaacc tgtgcaattt ttaaatggga gtctctccaa 3558361 gcaagagcgg gatacactcg ttgagaaatt tcaaaggaaa gaatatccga cactgattct 3558421 ttcactcaaa gctggaggca ccggacttaa tttgaccgcc gccaatcacg tcatccatta 3558481 tgacagatgg tggaacccgg cggttgaaaa tcaagcgact gaccgtgcat accgcatagg 3558541 ccaggagcgc tttgtccacg ttcataaaat gattacgaca ggaacaatcg aagaaaaaat 3558601 tgatgtcatg cttgaatcca agcaaaccct gaacgatcaa attatccaaa gtgaaaactg 3558661 gattaccgag ctttccacac aggagctcga agaattgttt acattaagcg ctacagcgca 3558721 ataatcatga ctaaaaaagc tggctctaaa agagccagct tttttccgtt catagccgtc 3558781 acgccgaatt tccaaaaaat ccgttacgcc ggttatcaac agggtgcgct tttgtggcag 3558841 cacatatact tacaacaaat gtttcatcat atgtgcgaca ccgtgttcgt cattggttaa 3558901 ggtgacagca tcggctatcg atttgatgtc ttcccgggca ttgcccatcg ctacaccttt 3558961 tcccgcagcc tccagcatcg atttgtcatt taaactgtca cctacagcag cagtttcctc 3559021 gagcggaata ttcagctgtt ttgcaagcct cttcagcgcc tgccccttgg aagctttgcg 3559081 ggaagaaagc tcaaagttgt gctcagccga actgacaagc gtcaaatctt cggcatgctc 3559141 atatcttttc cagcctgcct caagcttttc tttgaagaaa gaaaagccga gaatattgta 3559201 aaaatcgatt ggctcatcgg cttcaaacag ctcttgaaag gagttaatgt aagcaaagcc 3559261 cgattggctg tattgcacct cggccgcctg cttaaggaca gaaagatccg cttccggatt 3559321 tgcgcttctg aatctgtcga gctcaacatc aagaagttct ctgccgtttt gcggcgtata 3559381 aatcgctgaa cctgtgaata cctcataata atagttttcc gactcaagcc atgagagaat 3559441 gtcatacgcc cgtttcttat caatcgtttc gtgatgataa agcctgccct cgggatcgtg 3559501 aatgacggcg ccgtttgcac tgatgaccca tgttttgatc cccagcggtt caaagattga 3559561 catgacgtca aaatgagcgc gcccagttga caccaccact tcaatgccgt cccgctgcgc 3559621 ctgccgcagt gcgttttcat tttccaagct tacctgatgc ttgctgttga gtaaggttcc 3559681 atctaagtca atcgcaatta atttcacgtt tgtcagtcct ttccttcatc ctgctctgtc 3559741 acgagaagct caacgccgtt tcggtcaagc aagtcacaaa atgcctgatt cggcagcctg 3559801 tctgtaatca agaggtcgat ttcattcagc tccgcatact gataaaaact ggtgctgccc 3559861 agcttagaat ggtctgcaag cgcaattacc tgctttgcct gctgtatcat tttccgcttc 3559921 accatgccat cctcttcatg cgcaattgta atgccatgtt cggaaatgcc gaccacacca 3559981 atcagcgctt tatcaacatg gtagcttgag agcttttcaa tcacagagga cccgtacaga 3560041 aagcggtgct ccttttccag cttgcctccc agcagataaa tttcaattcc ctctttatcg 3560101 gacagcacat ccgcaagatt aatcgaattg gtgattacgg tacaatcaac cgcattcaaa 3560161 tgctttgcac atgcctgaac agttgtagag gcgtctaaaa tcacccggtc tccatcatga 3560221 ataagcgatg ctgcaagcct gccgatctta tttttttcct cagacactgt tttcaggcgg 3560281 ccggaatagc tttgaatttt ctgatgcaca gtcggtaaaa tggcgccgcc tcttgtgcgg 3560341 atgatggcat tctgttcctc aagtttcaca agatctcgtc gcgctgtatc ccttgacact 3560401 tgcaggagcg tacagatctg ctccgttgta attcggttat gctgttttaa aaaatccaaa 3560461 atcgctacta atctttcttc ttggtacacg ccctcattcc ttttctcagc aatcatttat 3560521 aagtaattat aagtttttat ttgattttat tcaacattaa taagtgattt taagtaaaaa 3560581 tgcgtcgaga gaaccaattt ttcctaagta ggcaaaaaga aagaaccagt ctggtcgact 3560641 ggtcaatttt gaggggatga tgcgaagatc cggataatag tgaatggata gataacggga 3560701 ggagcagggg tgtcaatcag cagctttttc ccggggttta gggtccataa aacgaacagt 3560761 gtcagccaac acttctgtta catacacgtt aacgccttcc tcgttttcat agcttcttgt 3560821 ctgaatccgt ccgcttacgc cgacgagaga acctttttgg caatacaacg ccgtgttttc 3560881 agctgttttt ctccaaagtg tgcaattgac gtaatcagct tcgatttcac ctgaagcatt 3560941 cttgaagctg cggttcaccg cgagcgtaac atgtgcaact gccgcaccgg cggaagtgta 3561001 gcgaagatca ggatcttttg taagacgtcc gacaagcatg acctgattga acatgcgatt 3561061 cctcctctcc ttgcggttgt atgtattgta aatgatgcaa caagaaaaga aaaacgctta 3561121 aaaatggctt tcagcctctg tttttatctt tcgttttcat ttttccttca gctaaaaaca 3561181 tcttttgctt ttttcctttg aagaaatatg tactttttaa aaaacggaaa aagatttgct 3561241 ttgtcagcca gttttgcgta ttcatgcgca cataggaaga gccatcccac gcaaaccact 3561301 gaaagctcaa ttttttttcc ggcattgaca gcttgatttt atactgctcc atgccatctt 3561361 gtgtttcgta taaaaaactt attcttcctt ttttgttcag atgaacctca aacacttctt 3561421 tacggcttaa catatatgtt acttcctttt gaatcaaatg actttcagaa ggaacgccgt 3561481 caatataaat ttcttttaaa cgaaattgat tcataccaca tctctccgta atccatagtc 3561541 agttacagta taatgaaaaa atagaaatta ttaaatgttt cgctcataca aaattcttta 3561601 gccccaacat tgcaggattt tttcctcgaa aacgtttatg ttataatgga aggcaagaaa 3561661 actttggaag taatcggggt gagaagaaat gaaaaccttt aaactggttg acctgaatgt 3561721 ggaacgagtg gacaaggaag aacaatcaat tgaacagttt ccccttattg acggactgat 3561781 tataaataaa gaagacggtg aaaatcactg gctgattgag gcgcttgtac agaaagaaca 3561841 tctgtctttt tttgaacagc ttcaaaacag ccaatctgaa gccaaagtat ttgtaacgat 3561901 cacgaaaaaa agcaatcgcc ccgcccagct gacagcagca gtgaaaaata tcgtcaagct 3561961 ggaagaaagc attcaggttt tactctacgg acaaatggtc acaagaaaac agcagggcac 3562021 tgaaaccatt ctcgagtccc ttgtaaaaga gggctataca ggaacaaaac tcattgaggc 3562081 atttaagcaa aaattataaa tatgaggggg catgttcccc aaaacagact cagaaccgaa 3562141 gagcatcaca atagacattt agaatagata tgttctgcat gaaaaaagct gccgttttga 3562201 acggcagctt ttctcttcgt gctttcactc ttgcatattt aatttgtatg gccaaaagaa 3562261 tcaaccaatt cccctttcac aacgaggcgc ccttcggttt tgaccgcctt gtcacatgtg 3562321 attaacgtaa tctccttttt gtttgtctcc tcaactacat ctgcatccat ttccgatatg 3562381 atgtctttcg atgttacaga atagatataa tcctttttaa aatccgtgat gacaatttgg 3562441 gcacctgttt ttatgttttc cagaggtccg aacagaagat tcttttgctt caaatgatgg 3562501 cccgccaacg gataatttcc ctcacccatt ttttgatccc ggcgcattgt tgccgcccct 3562561 atcaaaagat tttcattggt tgtgcctttt acgatcggaa gctccagatc gacactttta 3562621 attgttatcc gccgccttga ttgtgaagta aaaataagta tatttcacgt gctttcgacg 3562681 ttctccactt gactggaatg ctttaatggc gatcccggca tctgtagctt caggctttcc 3562741 ttcagaggaa tcagaaatct caaactctat tttctcagtg ttcagcacat aaccggctgg 3562801 cgctttcgtt tcaacaaaag cgtattgtcc cggtgcaagg cctgaagctg tgacttgatg 3562861 atgccggata tgactggttt cgaagtctgt atgaaaattc gcgaacgatt cagcatggtt 3562921 gatcttccgg ttctgatcat tacagctgcc attatcggcc atgacaaata caaggctttt 3562981 catgccggag cgaatgacat tttgcaaaaa ccctatcatt actctgaatt tatggcgcgt 3563041 attcaaaacc tgataatgat gaaacataca gcaaatcaag ccacaagaat ggaaatggcg 3563101 tttctccagt cgcaaatcaa gcctcatttt ctttataatg tattaaacac gattatttct 3563161 ctcactcatt tggatattga aaaggcccgg gaggtaacag aggaatttac caactattta 3563221 agaatgagtt ttgactttca aaatacatca gccatcagtt ccttcagaca tgagctttcg 3563281 attatcaatt cctatctttc tatagaaaag acgcgattca gtaatcggct tgaggttctt 3563341 ttcgatatag atgaagacat tgactttatc cttccgcctt taatgattca gcccttggtg 3563401 gaaaatgccg ttcttcacgg tgtcagcaag aaaagaggcg gaggatggat caaactgaca 3563461 gctaaaaaac aaagcaaaaa tgagtatcac atcaaagtag aggataacgg tcccgggata 3563521 actccggaaa aacaaataga tctcttatca acggattttg atcgcagcgt cggattgaaa 3563581 aatatcaatc agcggctgaa acatttttgc ggaagcgagt tgatgatcag cagcactccg 3563641 gatgcaggca cctctgtctc aatgctcatt catctcgctg aaacaacagg aagccctaaa 3563701 gaactgaagg acacagaacg aacctaaacg aaaattgaga taaaaaaaga cgccgtttct 3563761 aacggcatct tttttattcc ggcgactttg cttgctgctt cagcaggtct ctgatttctt 3563821 tcagcagctc ctcctgcgca tccaccgctt cctccgcagc ctcttcttct gcttcttttt 3563881 tgcgccttaa cccattcaaa gtccgaatga cgataaaaat ggagaacgat ataattaaga 3563941 agttcacaat cgtctgtata aagctgccat atttcactac agcatcgcca aacgtaaacg 3564001 acaggcctga aaagtcaagc cctcccagca gcaaaccgac caaaggcata atgatatcat 3564061 ttactagaga tgtgacgatc tttccgaaag cgccgcctat cacaacacca atcgcaaggt 3564121 ctacgatatt cccccgcatg gcaaaggctt taaattcatt ccacatacaa tcacctgctt 3564181 ttctatattt gtaaagaaaa aaagacaaat gtgccgctgg ccatctgcct tttttcaatt 3564241 attctccgag ggcaaaagtc agttctactt cgcaaacgac ttcgccatca actgtggcaa 3564301 cgccttttcc gcgcccgatt gtgccgcggg cacgaatgat ttcaacctca aggtgaagct 3564361 ggtcaccagg cttgacttgt tttttaaagc ggcagttatc aatgcctgca aaaaaagcca 3564421 gtctgccgcg gttttcttct ttaatcaaca tcgcaacagc tccgacttga gcgagtgctt 3564481 ctacgattaa tacgccgggc ataaccgggt actgaggaaa atgtccgtta aagaactctt 3564541 cattagcggt tacattttta tagccttttg cccgtttgcc ctcttcaact tccgtaatcc 3564601 gatccacaag caaaaacgga taacggtgag gaataatttc tttaatttgc tgagtatcaa 3564661 gcattgtctt gacatctcct tcatctgcat tagtatgtat agcaatcatc aaagatccaa 3564721 tctgtacatt tgaaaagtat attatgaatt aatctctttt tcaaccgcgc taaaatgtaa 3564781 ccaactgtca atgagagccg tcaaaagtta tgatatgata attatagatt ttaccaatag 3564841 caaagaggta ggaaaatgat ttcgaagttt attgaaaaaa gaatgctaaa catgttagac 3564901 gagtggtatt ccgcaatgag caaacgcaaa atgaatcacg tttgcacact gaaagagaaa 3564961 attgatcagc accttccaaa gatcaaaaag aacacaaaac tttggatgcg ttatcaattg 3565021 tttcaggccc gccatcagct gctttttgaa aaccagaacg gactcgattc attgttcgat 3565081 ggcctatatg gcctggaaga caaaatggat gatgaattga aatattatct gtattttttc 3565141 tctgggttat atgagatggt aaaaacagct ccgaaacatg cagtacatca ttttaaaaaa 3565201 gctgaacagt acctggccgc cattcacaat acgtttgaag ccgctgattt atattatcaa 3565261 accgccggcg cctattactt gatgaaatca ccgccgcttt ccgtccaata cgtcaaaaaa 3565321 gcattacaca tctatttgca ccaattcggc tatatcaaaa aggtaatcac ctgtaaactt 3565381 ttgctcgccg tgaattatat tgatcaagaa cgctatgaaa aagctgaaca gcttttcaaa 3565441 gaaatcatta agaaaaccca gcaactacat gacgaaaacc tgctatgcca cgcttattat 3565501 aaccttggct ttttaaaagc gaccgagaaa aaagaccagg aagcgcttct ttactttaga 3565561 aaagtattaa agaatcaaga atttgaaatg aattcaccag tctcatatct tcattgtgtg 3565621 tacgagtctg tcagagcgct ttttaaaaca gggaacatca cagaagctaa agccgtcctt 3565681 caaaaaggaa aagaattatc tgaaaaggta gacattcaaa ccatttattt aaaattaaaa 3565741 acgcttgaag ccctctacac atcagccgaa gacccttatg agcagctgct cgaatatgtg 3565801 cttgaattag aaaaaatcga ggcgtgggtg gatttagaag tgctgttaga agatattacg 3565861 gaatactaca aaaaaaagga cgatttcgaa aaagccgctt tttttatcat gcgcggctga 3565921 ttgaaaaacg cccattttct tattatctga ctgaattgat taaaccgagc atttgatctc 3565981 ccattgtgat cgttctgctg ttcagctgat atgaacgctg ggacgtgatc aaatctgtca 3566041 tttgttctga aatatcgaca ttggacatct caagtgagcc ctgctgcatg ccgatgtttt 3566101 gtctattagc gccgttcagc tcttcaaaag ctgccgcatt atcaatagag aaaaggttat 3566161 tcccttcgga tttcagctct tgagggttat tcacttggac aacgccaaga ttaaaccgct 3566221 gaaccgcgtt tccgtcagat gcggttaagg tgccgttctt attaatggtg atattcttca 3566281 ttgagctgtc gatgttcact gtattgccgt tctcatcaag tacgggatac ccatttccag 3566341 tgacgagctg cagctggttg gcattcgcag cggacggcgt tacatacagc gccccgtccc 3566401 tcgtatactg gcggtttcca tttacattta cctgaagata ctggtatgga gacgtaaatg 3566461 cgatatccag atcgcgatcg gtcttctgaa tgcttccttg atcagagact aggcgtgaac 3566521 tcatcatcgc tccgacgcca aggcgcaagc cgggcggcgt ttttcgggct tttgccactt 3566581 cctcgttttt ttcatcaacc tgatcgaatt gctgtctgac aagctcagaa aaattcgtat 3566641 cttttgcctt atagccggtt gtgttgctgt ttgaaaggtt gctgctgatt gtgtcaatct 3566701 gctgctgcag ctggtttaag gttgttgatg ccgttagcat tgacctgagc atagttgatg 3566761 tcccccgttt ttttcttccg ttttcttaaa tttttccaat ttcatttgct gctttatcca 3566821 tacttttatc gtaagcctga ataaccttct gattcgcctc aaacgatctg tacgcttcag 3566881 tcatttctgt ataggcgctt gtcacatcca cgtttgaaag ctctgagacg ccttgtttta 3566941 atgaataggc tacctgatta tttccggctg cgcttggcag atcattaccg tccgccgtgc 3567001 tgtacaaatc atttccgtcc cgtttgagat tgcggacatc ttccgccatt ctgacatcaa 3567061 tctggccggc tgtgcgtccg ttcgttgtca cagtaccgtt ttcagacaca gtgaaattct 3567121 cattatcaac agtgattggc tggcgatccg tcgataaaat agggcgtccg ttgatcgtca 3567181 gctgattgtt ctcatttagt gaaaatgtgc tgctttttga ataacggatt ccatccgctg 3567241 tttgaaccgg ataaaaaaga gcagcttttt cattggtttc cgcactcatc ggaacttgat 3567301 tttcgatcaa tgcaatgtct gtaggctggt ctgtggactt caggcttccc tgtgtaaaga 3567361 gaggcttgag ctcctgcata tatactccgg tattcacgga accgatttcc gtccttgatg 3567421 tcccggccgg agattttgat tctattctgc tgagcagcat ctcagggaac gcgcgcatag 3567481 agccttgatc agctttatat cctgatgtat ttgcgttagc aatattattt gaaagcattt 3567541 ccgttcttcg ctgctgggca atcattgcgg atgttgctgt atataatcct tttaacaaat 3567601 ttcccacctc taaaaatggc attttttcca gttgtcatat aggaacgttc gttctataat 3567661 aaaaactcag tattttatcc tattatcgtc atttaacatc ttttcgtgaa ggctttttca 3567721 taaaaaaacc tcattctttt tcagaatgag gtttgtgaaa tcagcttagt ttgcgtttag 3567781 gaagcttgtc catattatca agcatgacac ctgtgccgat ggctacgcaa tccataggat 3567841 tttcagcaac gaggaccggt accttcagct cttcagcaag cagctggtca aggccgttta 3567901 agagcgcgcc tccgccggta ataataacgc cgcggtcaat aatatcagca gaaagttcag 3567961 gcggtgttct ttcgagcact tgttttgcag cctgaacaat aacagcgaca gattcacgaa 3568021 gggcttcttc aacttcttta ctgtttactg taattgttct tggaagaccg gaaaccatgt 3568081 cccgtccgcg aatggaaatt tcctcgtgac gtgcgtctgg gaaaacagtt gcgactttaa 3568141 tcttaatatc ctccgcagta cgttcgccga tcagcagctt gtactcgcgt ttgatataat 3568201 ttaagatttc catgtcaaac ttgtccccag ccattttaat agaagaggag gtgacaatat 3568261 cgcccattga aataaccgcg atatccgtcg tcccgcctcc gatgtctaca accatgttac 3568321 cgcttggctg gaatatttcc atacccgcgc cgatagcggc aactttaggt tcttcttcaa 3568381 ggtacacatg tttcccgccg cttttttctg cagcttcttt aattgctttt tgctcaacgg 3568441 atgtaatatt cgtcgggcag caaatgagca tgcgcggctt tgagaacagg ccttttacat 3568501 tcagcttgtt aataaaatgt ttcagcattg cttctgttac ttcaaagtca gcaataactc 3568561 cgtctttcag cgggcgaatc gcaacaatat tcccaggtgt acgtccaacc attcgtcttg 3568621 cctcttcgcc aaccgccagc actttgccgc tgtttttatc aagtgcaaca acggaaggtt 3568681 cattcagaac aattccttta cctttaacat ggatcagtac atttgcagta ccgaggtcaa 3568741 taccaatatc ccttgcaaac atctatttat atcctccttg aaaatctgtt tcacagtaaa 3568801 tatccacatt gtgccctaat tatatatatt atcataaaat atagaaaaaa agttggaagc 3568861 acaataagtt ctttacaaat ttttgcggat gttttatgaa cgatttcaag aaggcaatgc 3568921 caggtgatta cgattgctga acaggctctc cttcgagaat ttcatctttt ttatatttga 3568981 gctttgtcgc ttctcctcct cttaaatgcc tgatggattt atgataatcg agtatttctt 3569041 tcacttcgtt tgccaagtcg gggttaattt caggcagacg ctctgttaaa tccttgtgta 3569101 ctgtactttt ggaaacacca aattccttcg caatgacacg aacggttttc tttgtctcca 3569161 cgatgtactt ccctatcttg attgttcgct ctttgatgta atcgtgcaca ccactcgacc 3569221 tccctaaaat ggatgtgaga agtgtgaaat gagatccgta ttctgtaaag agtcgttcat 3569281 tatgccgctt cttcgttgta tggttttaaa agtaagtttg tgaaatatgc ccacgatccc 3569341 tcacctcaaa cactctcttt gttaggtttg taacagtgta ttagcattct tttgggaata 3569401 tgctaaaaac tcaataagga caaggggtga aacgaacttt ttcagattca gcaaactatt 3569461 tcgcgtcact aaattttcat ctttacaact attgatcgct cctgtaaaat gaaataagca 3569521 attagttact taggtaagtt ttttagaagg agaccgacat gtcctacgtc aacagacacc 3569581 tcattcatca aatcaaccaa agcgcccgcc tgattgccaa gaaagccaat gaacagctag 3569641 agccattcgg cctttattca tctcaatggt cagttttata ttgtttgcgt acgatcggac 3569701 caatgactca aaaagagatt tggtcctatt taaatgtgga agcgccgact gtgactcgga 3569761 cgatcaaacg cctggaggag aacggctggg ttcagagacg gcaaggtgaa gacaaacggg 3569821 aaaaacttgt tgtcctcaca aaagaagccg agaaaaaata cgaagaaatc aatgtgaaaa 3569881 tgttgaaatt cgaggaagag ctgcttgcag atttccggga tgaagataaa gaagcttttt 3569941 ctcatttatt ccgcatgttt ttacaacaat gaaaataagg aagtgacata catttgaaaa 3570001 aagcggatgc gatatggacc aaggatttta ttatggtcct gcttgtcaat ttatttgtgt 3570061 ttgtgttctt ttatacattt ttaactgtat tgccgatcta tacactgcaa gagcttggcg 3570121 gcacagaatc acaaggcggg cttttaatca gcctgttcct tctgtctgcg atcattacac 3570181 ggcctttctc cggagccatc gttgagcgtt tcgggaagaa aagaatggcg attgtatcaa 3570241 tggcgctctt cgccctatca tcttttctgt atatgccgat tcataacttt tccctgctgc 3570301 tcggattgcg gttcttccaa gggatttggt tcagcatttt aacgactgtt acaggtgcaa 3570361 ttgccgctga tattattcca gccaaacggc gcggtgaagg gcttggatac tttgccatgt 3570421 ctatgaacct cgctatggcg atcgggcctt tccttggcct gaatttgatg agagtggtaa 3570481 gctttcctgt attctttaca gcctttgcgc tgtttatggt tgcgggctta cttgtttcgt 3570541 tcttgataaa agtgccgcaa agtaaggaca gcggcacgac tgtattccgt tttgcgttct 3570601 cggatatgtt tgaaaagggc gcactcaaaa ttgcgacggt cggtttgttt atttctttct 3570661 gttattcaac agtcacatca tatctgtctg tattcgccaa atcagttgac ctttcggata 3570721 tcagcggata tttctttgtt tgttttgcgg tgacaatgat gattgcacgc ccgttcacag 3570781 ggaaattgtt cgacaaagtc ggaccgggca ttgtcattta tccatcaatc ctgattttct 3570841 ctgtcggact ctgcatgctg tccttcacac atagcggctt aatgcttctg ctttcagggg 3570901 cggttatcgg tcttggctac ggatcaatcg ttccttgcat gcaaacattg gcgattcaga 3570961 aatctccggc tcaccgctcc ggttttgcga cggcaacgtt ctttaccttc tttgacagcg 3571021 gaattgctgt aggatcgtat gtattcggat tgtttgtagc atctgccggc ttctctgcca 3571081 tttatttaac agcggggctg ttcgttttaa ttgctctgct tctctacacg tggagccaga 3571141 aaaaacctgc agaggctgaa ggaaaagtgt ctattgcaga ataacttgtc agactgccgg 3571201 gaaatcccgg cagtcttttt tccattaaaa cacggcgccc tctcggttga acgagagaac 3571261 gccgcttata gcaattattc aatgacaggc cgcgcaggtg aatcaggatc taacgaaaaa 3571321 tcataggacg cttcatcacg aaacatcgga tcggcatata tggattgttg atcgtttttt 3571381 gttgcttttc gatacgaaga aaatgaatca tattctttct ttttccacat ccatatgccg 3571441 tcttgatccg cttccttgtg gtacacgtta tgattgaccg tattaccttc gttttctgta 3571501 aagtcgtttc cgataaataa tctggaatca ccggccgtca atatattctt ttcaattgtg 3571561 ttgtttttcg tatcgtactg cagcagcagc tgtccgccgt acagtccctt tgtgtcattc 3571621 cggtacataa tattgcgggc aatcagagaa ttgctggtgc cgccccgctt tttgtcatat 3571681 cctccgattg aaataccggt gtacgcattg ttgtacactt tgttgtctgt gatctgaatg 3571741 gcatttgcat actttccttt gtgttcagac gttgcttcaa tcccaatatc gttatcgtaa 3571801 actgtgttgt tcttaatttc gatatcgtgt cctccatcga cataaatccc gcccgctgag 3571861 tattcatctc cataagcagg attgccgtaa gtcgagtttt gataaactgt attgttttct 3571921 acgactccgt ttcgcacgta atcgttttta tccgcggttc cctcataacc aattagatca 3571981 atcccgatgt tattattgtt gcggaccaca ttgcctgcaa ctgtgaagcc gtcgatatta 3572041 ccgttcagca caactgcttc actcgctcca agcgtcagtt tctcaactgt attgtcctcg 3572101 attcggatgt ctttcatgct gccagtccca taaactgcga ttccgtgagc atttccttca 3572161 tccgctgttg tcttaatccc ccggatgtga ttatccttaa tggcgatatg actgctggac 3572221 cctgatacat aaatccctat agcagttgct tcctcagatg aaacagaaag atcttgaatt 3572281 gttaaaccgc tgatggcaat gtcatgttta tcgtgaatac gaataagcgg tgtttcatat 3572341 tcagcgttcg caacggattc accgctaatc acgacgtttt cattttcata gtttcggaat 3572401 gtgataggct ttccgtccgt accgctgtgc tttacatcaa gggtctcatg atacgtgccc 3572461 tcccgaatca tgacagttgt gccggcagca gccttctcag atgcgtgtgc caatgtacga 3572521 aacggctttt cttttgttcc ttcattttga tcactgccat ttggcgaaac atacagataa 3572581 tccccagatc cttcctcatt cgcttttgtc ttatcataaa cgaaagcgag gatgacagac 3572641 gttaaaacac ccgccaaaag aataaaatac cattttctca ttttcgattc ccatttcgtt 3572701 ttagaataga tttctaaaac cattataaat gttctattta tggaaaacca tttcaaaaat 3572761 atgaaaatat accgtctaaa tagatcttat tcagcctggc ggacctgcgc atgttcaact 3572821 gtttcaattg ccaatgatgc aggcgggtga acacgcatca gaacaatgta gaaaagaaag 3572881 gaaatcagca cacctacaaa ccaagaaata tcgtataagc tcttcaatac aggaacatac 3572941 atgccaatca gcgaaatcag cgctcctaac attgtggctg caaacgcacg gtaattgtag 3573001 cccttccaat acacataccg tcctgtttcg gaatacaggt catctaccga gagctcacgt 3573061 ttgcgaatga taaaatagtc ggccatcatc acgcctgcca ccggtccaag catgccgcct 3573121 attaagccaa gaaacgcata cacgcttgtc gcgctctcca tcagcttcca cggaaccgta 3573181 aataaagcga gcaacgctgt gataaagctg ccacgtttga aattgatata tttcggcagg 3573241 gcattcgcta tatcataagc gggtgatacg atattcgccg cgacatttac agagatcgtg 3573301 gcgatgcaga gtgtgatcac ggacaagacg atgacataag ggttatcaaa ccgcgccaaa 3573361 atatcgacaa catcccaaat cggctctccg aacgcgacct gcgagccgga ggtcaccgta 3573421 atacttgcga atgcgaacag cgcaaacgtt cccggcaaac cgtaaaattg tcctttgatt 3573481 tgctcttttt gtgtttcagc aaaccgtgta aaatcaggta tatttaagat caatgtcgcc 3573541 cagatgccga tgatgccagt aactccggca gcaaacggcc agaatgtttc tgaaaacgta 3573601 tgaaactttc ctggttgaga gtatatcggg cccaatcctc cagcaatatc aacggcccac 3573661 cataccatgc cgccaaatac cagatacact aaaggccctg cccacacctc aaaacgttta 3573721 atcgactcca tgccgtgatg caatacgagt aaatgaatgg cccaaaagaa tacaaaggaa 3573781 agcaaaccgg acaagtgaat gccgagaatg ttccactcgc cgccaatttc tccccaacct 3573841 ggccacatat tcaaaagcaa aatgttcagt gccgtgctac ccgcaaaggt ctggatgcca 3573901 agccacatga tagctgtaaa cgcccttaga agcgcgggga tattcgcgcc gtatatcccg 3573961 taagaagccc gaatgatcac tggaaacggc agcccgtatt ttgtccccgc atggccgttt 3574021 aaggcaagag cgccaaatag gataagtgat gccgtaataa tgatcgccag cacctgccaa 3574081 ggcgaaaggc cgatcgcaat taatcctccc acggtcgcgt aggtcggtat gttatgtata 3574141 catcccatcc aaatggaggc aaagttcatt gctttccacg tccgtttttc ctgtcccaaa 3574201 ggcaccagat cttcattgct cagcctgttg gattgctgct gactctcttt taatttcata 3574261 gccggctccc ctttccatat tgtctatatg tcgtcacacg ttatgttttt tgacattaga 3574321 tgtcacttaa tataactgaa gagtcagaca ataacactgg ctatgatata caattttccc 3574381 gtttgtattt gaacagctta aacaagaaaa agagacagac ctcagagccc gtctctttct 3574441 taagatgcag ttttcattaa tgcagcaaat ctcacagcca ttaacaggct tgctccgccc 3574501 gctataatca taatgattcc catcatatca aaatgggctg ccgtgatttc tttaccaaaa 3574561 agaatgccaa ggatcaccga agacaaaatc gatcctaggt aacggcaggt ttgaaacagg 3574621 cctgaagtcg ttcctaccat gttggaagga ctcgtttcca gcatcgctgc ctgaagcgcg 3574681 acattgccca gtccgtagcc tatacccaag agcgacagaa tgaggccttt accgatggtc 3574741 tggacattga taaaaaagat ggttaagagc acggctccag ccgtcatcaa aagcgctccc 3574801 gcaaagatcg gcttgacgac accagatcgg tcgatccatt tgccggttag aggtgacaca 3574861 acgatgctca ttccagacat aaacagcata aacaggccgc tcgtttgaac agaaagatgc 3574921 atttcatcct gaaagtaact tggcaaacca aaaaataaac aatagaagaa aacattcaat 3574981 aaaataaact gaacatacac ggctgacagg tttcgctgtg ttttaaacag acggacatca 3575041 ataaacggct tatccgtttt cagctcgcgc cagacaaacg cacagagcag aagcaagcca 3575101 agcacacctt caaccgcatg cggcgacgtg ctgaacgaca gcaaaaagga tagaaggaaa 3575161 atgattcccc cggcaaataa aacaattcca agaatatcga gctgccgaat aatggttttg 3575221 attcctgccc cttttttctg atctttcggg aacatataca ggcccaataa gaagctgagg 3575281 ataataaacg gcaaattaac gataaagatc gccggccagc ctccccatac aatcaaaaac 3575341 ccgccggctg tcggccccag cgccgtcatg gcggacgcaa aaatagagag tacagccaag 3575401 gctgaagctt ggcgctcatg aatatgattc cgaatcaagc cgacacctga cggataaatc 3575461 gcactgctcc ccaccgattg aaacagccgc atgaccaata atgtcataaa cgtcggcgca 3575521 aacggcgccc cgatggcaga aaccgcaaca agaataagcc cgaataaaaa caagcgtttc 3575581 cgcccaatca aatcaccgag ctttcccgtt acgggctgcg ctacggcact cgccaagtaa 3575641 aacgaggaaa tcagccagga aaccgttgta aacgagaggt gaaactcatg ctggatgcta 3575701 tggagcgcaa gagagatcat agacgagttc agcggattca gcattgttcc cgaagccaca 3575761 gctgttaaaa aaacagctcg gctttttttc gataacatca tttcacttgt tccagaaact 3575821 cttccgttgt ccgcgattta ccgattctcg ggaaaataaa gcgcagtgtg gcttcatgct 3575881 cttcatcgct aaatgtggac atggcatctg taataaaaat ctgctgatag ccaagctgaa 3575941 atgcctcccg tgctgtgctt tccaccccga tattcgttgc gatgccgcac aatacaatcg 3576001 tatcaatgcc gcgacgtctc agctgcaagt ctaaatctgt gccaaaaaaa gcaccccatt 3576061 gccgttttgt cacagtataa tcgccatcct gcacaccgat ttccggaaca aattcggccc 3576121 agtccgccgg catttcccct gaacctccct gcgcaggctc atccgtttgc ggcttcaggg 3576181 cgtccgctcc atcatgaaag gctacattta caaagctgat gaacccgtta tgtttccgaa 3576241 attcatctac gagctttttc gcgttcggga caacctggcc gctttgatca atcggcacaa 3576301 ttcccttttg taaatcaatg ataaccaatg ctgttttttg aaaatcaatg ttgagtgtat 3576361 tcatcatacg tctcctcctg atactgttag tgtttctcac attgcatatt ttactcttca 3576421 cactgcctaa gttcttttat gatgcttgtg aaattctcag aaggagcgtt ttctcatgat 3576481 ttttctttta tgtagtagta acaggttgtg catacgaaca aaccggcaag cactgtaatc 3576541 ataaagggcg tcatcgcttc atcacctgcc tgctgtctat cggttcctgc ctgaaaatgc 3576601 ccatgaattt gcggcggtcc atccaaagca ggataagaca cataaccatt aatatcgtgc 3576661 taagatcctg cacgccaata tcaaaacaat agttaatcaa gacgatgttc acaataatgg 3576721 gcataaaaat aaccgcccct aatgcagccg ttcgcggaat cagtaataaa acagctgcca 3576781 ggatttcacc aaaacctata aacagttcat agacatgaga ataaccgaaa aatgtccacg 3576841 cgatcgtaaa ccccttcccg gcagccgcct cgatttcagg cgtcacctcg ccaaactggc 3576901 caattaccac tttcgccaga ccgtacacga aaaaattaaa ggctaaaaac aatcggaacg 3576961 tcgcgggaat cgacttgcgt accgctttcc tcagcctgcc gcctttattc atcatacatc 3577021 cccctcagtg tattatttga tgtagtacac ttaatacagt atagagtatt ctaattaatg 3577081 tcaattccct tttcagctca tatgaatagt ttcttttata gatacaaagt cttatatcgc 3577141 aaaaaatgcc attctccttc ctttccatcc ctcgataaca tttctcaaaa accatgtcag 3577201 gaaatcttac atgaaaatgt tttatcattc ttttttctct ataatgaaga aatataataa 3577261 ttgcttttta ttctgaaaga tacggaggaa tgagacatgc aaatgggcga tacagttttt 3577321 atgttctttt gcgctttact cgtgtggctg atgaccccgg gattagcgtt attttatgga 3577381 ggaatggtaa agagcaaaaa tgtgctgagc actgccatgc acagtttctc ttccattgcc 3577441 atcgtttcca tcgtttgggt gctgttcgga tatacacttg ccttcgcacc aggcaattca 3577501 atcatcggcg ggctggagtg ggcaggcctc aaaggggtcg gatttgatcc gggagattac 3577561 agcgatacca tcccccactc gttatttatg atgttccaaa tgacgttcgc cgttctgact 3577621 acagcgatta tttccggggc tttcgcagag cggatgcgat tcggcgcttt tcttttattc 3577681 tcggttttat gggcctcttt ggtttacaca cccgtagcgc actgggtatg gggcggcggc 3577741 tggatcggcc agcttggagc gctcgatttc gctggcggca atgttgttca tatttcctcc 3577801 ggggtggcag gacttgttct tgccattgtg ctcggcaaac ggaaagacgg tacagcgtct 3577861 tctccgcata acctcattta caccttctta ggaggagctt tgatttggtt cggctggttc 3577921 ggctttaacg tcggcagcgc attgacctta gatggtgtgg ccatgtacgc gttcatcaac 3577981 acaaacaccg cggctgcagc cgggatcgcc ggctggatct tagtagaatg gatcattaac 3578041 aaaaaaccga caatgctcgg agcggtatct ggggcaatcg ccgggcttgt cgccattacg 3578101 ccggctgccg gatttgtcac accgttcgct tccattatta tcggcatcat cggcggagct 3578161 gtttgtttct ggggagtatt ctcgcttaaa aagaaattcg gatacgacga cgcgcttgac 3578221 gcctttggcc tgcacgggat cggcggcaca tggggcggaa tcgcaacagg attattcgca 3578281 acaacctctg ttaactcagc gggcgcagat gggttatttt acggtgatgc aagcttaatc 3578341 tggaaacaaa tcgtcgccat cgccgccact tatgtttttg tatttattgt cactttcgtt 3578401 attattaaaa ttgtaagcct cttccttccc cttcgcgcaa ctgaagaaga agagtcactt 3578461 gggcttgact taacgatgca cggggaaaaa gcatatcaag attctatgtg aggagtgacg 3578521 ctatgagcgg tcaaatgttc aaggtagaaa ttgtaacgcg tccggcaaat tttgaaaagc 3578581 tgaagcagga actcggaaaa atcggagtga cctctctgac tttctccaat gtacacggct 3578641 gcggccttca aaaagcacat acggagctct atcgaggggt aaaaatagaa agcaatgtat 3578701 acgagcgttt aaaaatagaa attgtggtca gcaaggttcc tgttgatcaa gtgacagaga 3578761 ccgctaaaag ggtgctgaaa acgggatcac caggtgacgg taaaatattt gtctatgaaa 3578821 tcagcaatac gatcaacatc cgcacaggcg aagaaggacc tgaagcactt taatatcggt 3578881 acgagattcg gacactccgg atctcttttt ttgtgcacag aatcccccca gaaaccgcga 3578941 ttcctcttcg aattctcttc aagcgccgtt atttcagaca atctctattt ttatttgaaa 3579001 cttttcatga gtaagattag tctactaaat ataaaaatgt aaaaggtgat tatttgaact 3579061 acgaaatttt taaagcaatc catggactat ctcatcacaa ttcagttctc gattccatta 3579121 tggtcttcat cacggaatat gccattgtcg cctatgccct tatcctattg gcaatctggc 3579181 tgtttgggaa cacacaaagc agaaaacatg tgctatacgc aggcatcaca ggaattgcag 3579241 gccttgtgat caactatttg attacgcttg tttatttcga accgcgcccg ttcgttgcgc 3579301 atacagtgca tacactgatt ccgcatgctg cggatgcttc atttccaagt gaccatacga 3579361 caggtgcatt agcgatttct attgcgatgc ttttcagaaa ccgcaaaatc ggctggccgc 3579421 ttgtcatttt tgggcttttg acaggctttt cgagaatttg ggtgggacat cactatccgg 3579481 tagatgtatt gggcagcctc gttgtcgcca tcattatcgg gttccttttc tttagatttt 3579541 cagatctgct tcgcccgttc gtcgatttgg tcgtgaggat ctacgaagcc attatcaata 3579601 aactgacgaa aaaaccaacc gatcaaaatt tctaagaaag acaaaagccg gcgtctgaaa 3579661 tcaagacagc cggctttaat atttctcata catctcttgt tttcttcgct tcgccaacac 3579721 atataaacca taaaacaacc caattccaac agcatcgatg agcacatccc ggatacaacc 3579781 attcctgctg aagaagagct gaagaacttc tgtgaaaaaa gcaaacgcaa atgagccggc 3579841 tgcagctgat cttatgctgc cccgctgttt ccacagcaaa tatgtcagca caaagaagga 3579901 aaacgcgtgt ccgatttttt gaataaacgc ttcaggtaca gtaagctcag taaaatccat 3579961 aactaaaaat tgagacagat cagggtgcgg ctgaaaatga aaagccaccg tttgcgatac 3580021 gaccatgccg ctgaagcttt ccgtacagac agaaagcagg ataaaaaaga tccagcctgc 3580081 gagcaatagg cggttcatga cataacctcc tttataacgt acgtgcctac atgtaactac 3580141 atagacggta aaacaaagca aaaagtaaca gaaaaaaacg cccatcacaa ggatagacgt 3580201 tttcttcatt aagactgttc agtgtcttct gttgtgctgc tttctttaga accagatttg 3580261 tcagttgaat catccttttt ctcaccggat ttttcttctg ttcctttttc agttgatccg 3580321 tcctttttct cggaagattg ctgaatggat tcttctgttt cttgggtggc agctttttca 3580381 atagaagaaa ctggtttgtc cataaagttt aacggattca ttgcaacccc atctttacgg 3580441 atttcaaagt gcacgtggtt tccgctgtct tcactgtaaa ggttcttgcc agattttccg 3580501 atcacttgat tttgttttac tttgtcacct tgctctacgc ttacttcgga aagagattga 3580561 tacacagtcg ataaaccgtc ggcatgttct acttccacaa catatcccag cactggatct 3580621 ttttcagctt taacaaccgt accgctcaga gaagcagaga catcgaaatc ttttccgtct 3580681 ttctcagcta agtcaattcc tttgcttagg ctgtacgtgt tattataggt aacgagtgct 3580741 gcttctttct cttcttttgc ggcatcggtt tcatagaact ttttcacaac agaaacgttt 3580801 tcagaatcaa caaccggcat tgcgacattt tccattgact ttcctacttc aactgcatcg 3580861 tcgttgttgt catatgcgga gtttccgccg ttatcagcca actgatcctt tacctcatca 3580921 tttgatactg attgatacca aaggacagct gttaaaatga cggccgcact gactaagtaa 3580981 attgcaggga acacccagcg tttacgaaaa aactgctgaa gttttttgac ttgagaagtt 3581041 ttcttttctt cctctctcat tgtttcatca cctcagcaac attctgaaca cttttctgaa 3581101 aatatataca acctatccaa aaaaactttt ttagatgtag tttgcacaga ctgaacgaaa 3581161 atatgtattt ttttgagagg agtgccaaaa acgtatgaac atgacattgc gtcttgctga 3581221 acatagagac ttggaggctg ttgtggcgat ttataattca acgattgctt ctcgaatggt 3581281 aacagccgat accgaaccgg taactcctga agaccggatg gaatggtttt cgggacatac 3581341 agagtcacgt ccgctctatg tggccgagga tgaaaacgga aacgtcgctg cctggatcag 3581401 ctttgaaaca ttttatggaa ggccagccta taataaaaca gcggaagtca gcatatacat 3581461 tgacgaagca tgccgcggca aaggtgttgg atcatatttg cttcaagaag cgctccgcat 3581521 tgccccgaat cttggcatcc gctcacttat ggccttcatt ttcgggcata ataaaccaag 3581581 cctgaagctg tttgaaaagc acgggtttgc agaatgggga ctattccccg gcatcgccga 3581641 aatggacggg aaaagatacg atttaaaaat tttagggaga gagctttcat gattagtctg 3581701 gataaagatg aaaacgaaat tgaacatcat aatgaagaaa atagccttgt tgaacaggag 3581761 actgcacctg ttggacagga gagccgccag ctgagcgcct ccgctgtcaa gtcgctatcc 3581821 gacattgcca agtggggcaa aatttctggc atcttgttaa tcattatggg atcgcttgtc 3581881 actctgtctg ttttgatgac agtgattggc gccatcccgg gcgtactgct cattatttca 3581941 ggcgtatttt tgatgcgctc agcaaaagca gccgcggaag ccgaaggaaa tctaaccggc 3582001 agcgctggcg aaagcatgct tgaaaattac gggacattta taaaaatgca gctgttttat 3582061 gcagcatcca gtatcgttac tgtcctgatc gggatcattg tagccatttt cgtgctggtg 3582121 gtaatcggca ttgctgcttt tgagaacacg ccttcgtatg atgatccgga ttcttattat 3582181 tatgaggatg atccggtgtt tgaataatga tgagacagga cagggcatga gttccatata 3582241 aacggaacca tgcctatttt atttgactat tcaaagcagg ccggcgtaaa caccaaatcc 3582301 tgaagcaagc atacaataga catctctagt agaggaaatc aacaaagcaa cgctgttacc 3582361 cagaaatgaa tatcaaaaaa acggatgaag tcggaatcaa tccgaaaccg cactttttat 3582421 ttcgggtgtc tgcatgcaaa aaaacacacc cggatcgtct ggaaaatctc aacaatccgg 3582481 gtgcagatct tctttaatac atttttttgc gtctgtcttc ctcagtcaaa aattcaacaa 3582541 aactccgcat cgcaaaaggc tcttccttta tttgtcgtgc gtaggagctt ttccgctctt 3582601 ctgaaaggat ttcgctcttt ttgatcctgt tcagcatata gatgtgaacc gttttttgga 3582661 tttgtttatg ctgatagcct gcctctttaa aaaatgcgag cccgagcgcc gccaaaaggg 3582721 cgaatatgcc tgcgctgatc agggactccc tgtcagctga agcatgaaat agaaaagcag 3582781 ctaaattaaa gagagagaat gcagcaagcg gaatagcaag aaaacggtaa atgacggttt 3582841 ttttcatgaa aggctgtacg gccttttgaa ttttttgcat ttctgttttg atgaaccccg 3582901 gcatttgttc gactctgtaa aagttcatat aatcctcccc ctttatttga tgtttcaagc 3582961 ttcacgaacg ttatcatatg tgtttatttt aacgcaggtg caagctggtt ttaaagaaat 3583021 ctgcccgtat ttttcacgaa gaatctggat cgccgctctt tattctttta aaatgtgagt 3583081 gttataattt gtaatgggaa tcagatcact gttattcatg gaatactaat ggcaatcttc 3583141 ttgataaata tgaatgagcg gggttacaaa gtgagtattt cttccatcct tttatcactt 3583201 tttttcattt taaatattct tttggccatc attgtcatct tcaaagaacg gcgcgatgcc 3583261 agtgcatctt gggcgtggct gcttgttctt ttctttattc ccgttttagg ctttatttta 3583321 tacttattat tcggccataa tctcagacgc aagcatttgt ttcaatggga agaccggaaa 3583381 aagattggaa ttgaaaggct gctgaagcat cagcttgaag atttagaaac caagcaattt 3583441 cagtttaaca accgggcaac ctttgataac aaagatttaa tttatatgct gattatgaat 3583501 aaccatgctg tgtttacaga ggataattca gttgacgtca ttacagatgg acgggataaa 3583561 tttcagcggc tgctgagtga catttcaaag gctaaggatc atatccattt acagtattat 3583621 atttataaag gcgatgaatt aggcaaaaaa ttgcgggacg ctctcatcca aaaggcgaaa 3583681 gaaggtgttc aggtcagagt gctttatgat gaactcgggt ccagaacgct gagaaaaaag 3583741 ttttttaaag agcttcgcga ggctggcggg catgtggagg tctttttccc gtcaaagctc 3583801 aggccgatta acctgcggct gaattaccgg aaccatcgaa agcttgtgat catagacggt 3583861 atgaccggtt atgtcggagg ctttaacgtc ggagatgagt atctagggct taatccgaaa 3583921 ttcggttatt ggcgggatac gcatatccgg ctgcaaggaa cggccgtgca cgccatccaa 3583981 acacgattca tccttgactg gaaccaagct tctcatcacc atacgctgac atatattcca 3584041 aatcactttc ctgattacgg cccaaaaggc aacgtcggga tgcagattgt cacaagcggc 3584101 cctgattcgg aatgggaaca aattaaaaat ggctacatca aaatgatttc gaacgccaag 3584161 cgttccattt tgatacaaac accttatttt atcccagatg caagcctgct ggatgcttta 3584221 aggatcgctt gcctttcggg cattgacgtt aacattatga ttccgaacaa gcccgatcac 3584281 gcctttgtat actgggcgac actttcgtat atcggcgatc tgctgaaagc cggagccact 3584341 gtctatattt acgataacgg ctttattcac gcgaaaacca tcgtggtgga tgacgaaatc 3584401 gcttcagtcg gcacagcgaa cattgatgtc cgaagcttca ggctgaattt tgaggttaat 3584461 gcatttattt acgatatcac cattgctaaa aaactggttt caacttttaa agaagatttg 3584521 ctagtatcca gaaaattcac ctatgaggag tatctgcagc gcccgttgtg gattcgaata 3584581 aaagaatccg tctcgcggct gttgtcgccg atcttataag atgcgtaaac ccccggcctt 3584641 tacggccggg ggttttcctg atggtcacag taaatgatga ttgcctcccg caaaaaagcg 3584701 gcaagacctt ctccatattg attgattgaa tcggtaaatc gctcgtcagt gatatacact 3584761 tccccgagtc ctctgaaaat gtcgagtgtg caatcgtaat gatattggca aatatgatcg 3584821 cgaaatgccc ccacagcggc ctgaatctct gcatcatcgg gcccatgctt cattcgcgcc 3584881 gcaattcgtc tgtaaatcga atcaaattca gccatgatcg tgcgccaatc atctgccgag 3584941 tatgcagatg tccttttctc tgtttcttct gcgatttcct ttccatacag ctttctgact 3585001 tcatcagcgt atgtctgctg gtgctcttca atgtctttca tgcttaatcc ggcaaataaa 3585061 tccctcttat tcatcgtttc ccctccatca acggacaaaa gcgtcctgtc aattgtttga 3585121 atcatctcat ccattctttg ttttttcttc atcaatatct ccttttgcga ctgaagtgcc 3585181 gctttccggt caaaattcgg atgatccagc atctctttaa tctcatccag acgaaacccg 3585241 atttccttga aaaataaaat ctgttgcagt ctttccaggt ctgcgtcact gtacaaacga 3585301 tacccagcat cagtaagcgc tgaaggattc agaagctcaa tattgtcata gtgatgaagc 3585361 gtccgaatgc taacgcctga tatctccgcc acttgtttaa cttgatattt catacataac 3585421 acctcctctt ttttatcgta aacaatcacg caacgttagg gtcaatcccc aaaatgttat 3585481 tttctatata caaaacttct cacaaatagt gtataaaaga aaagtgagta tttttttgta 3585541 aaggggagcc agtatacatg aatcctgaaa caatgaacaa aaccctcatc agcatttcga 3585601 aatggggaaa agctacaggc attttattta ttattatggg cgcaattacc gcgctttcag 3585661 gcgcgttctt ttttctaatc ggtgccgtgc caggcgtact gcaaattatt tccggtatct 3585721 ttttgatgag gtcagctagg gaagcaggcc aaatggctga acacaatagc ggacagtctg 3585781 aagacttaat gctggagaat tacgcgaaat tcgtaaagat gcaagggatt tatttgatcg 3585841 taagcattgc tgtatccatt cttgcgatta tcgccttctt catcttttta atgcttggga 3585901 ttgctgacgg ccttttcagc gatacgtaca gcacttatta atgagaaaaa cccggagctg 3585961 gctccgggtt ttttattatt ccgcttcgct taccactgtg aagcgttcat ttttgtgttc 3586021 gggatgttca agctcgtcca acacggcaat ggcataatct gcatagctga tatagctgtc 3586081 tccttttgca tttacgatga cattgtcttt tcctttttgg taagagccag tccgttttcc 3586141 tgctggatca aaaaatgccg caggactgag gaacgtccag gaaatggagt ctgtctgctg 3586201 caaatctttc aggttctcgc cttgatttga tgcagttggc aaatattctt tcggaaattc 3586261 cggcgtatcc attaaacggg ttgttttggc ttcatcaaca aacaggcttc ccgctccgcc 3586321 aacaacaagc aatcttgtgt gcttcgcgtc ctttaaaatg ctgatgagtg ctcttcctgc 3586381 ttcaacatga agatgttctt ggccgggtgc tgctccaaaa gcgtttacga ccgcgtcgaa 3586441 aggcttgatg tcttccgcag tcagttcaaa cacatctttt tccaaaatcg ctacgtcttg 3586501 ctcctgcact tttgaagcgt ttctgacgat ggctgtcact tcatggcctc tttttttcgc 3586561 ttctttcaaa atctcgtttc ccgctttccc gcttgcgcct ataataccaa ttttcatttt 3586621 tcatttcctc cttatttgta acaattttag ttacatgtta gcggtgagaa gtcatccctt 3586681 ttgattaaaa gagatgattc ataacatctt ttaatgactt gcttgccagt tcattttcca 3586741 tcgctctttg cacactttca aacgtttcat ccagagcgtt ctgaattttt ttccctaccg 3586801 gacatttcgg attcgggttt tcatgaaccg caaagagttc ttcttgcttt tggacagccc 3586861 ggtacacttc taaaagagaa atatcagcag gatctttttt gaggcttgca cccggcaccc 3586921 cggcgcgtga tgtgagaata tcagcttttt tcagcaggct gatcattctt cgcacaacta 3586981 ccggattcgt gttgacactg tctgcaatga tttctgaaga tgttttttca tccatcgaga 3587041 tgagggataa aatatgaatg gcaacagcaa gacggctgtt aatcatgttt tttcaccacc 3587101 gttgtaacta taatagttac atttgattcg tttgtcaaca tctaatatac actaaataca 3587161 tgggttttgt gcaccgtttt tagtcaatag aacggccgga tgcactccgg ccgcgtctta 3587221 tcaaaataag aaatatcttt gtccaagtgg gacataatcg acaggctggc aagacaattc 3587281 ctccccgtca gcaaagacct gataggtttt tggatcaatc tcaatcttcg gcaaagccga 3587341 attcagcttc atatccagct tgctcagctt tctgatattt ttgactggag aaatcctttt 3587401 ttccagccct aagctttccg ccacaccacg ctctatgctt gcctgagaca taaatgtaat 3587461 cgaggttgag cggttggctt ttccgtaaga cgcatacatt tggcgcatga aaaccggttc 3587521 aggagtcggg atggacgcgt tcggatctcc catttgcgca cgtgcaatca tgccgccctt 3587581 taagaccagt tccggtttca cgccgaaaaa taccgggtcc cacagaacga gatcagcaag 3587641 cttccctttt tccaccgagc cgacctcatg gctgagcccg tgcgtaattg ccggattaat 3587701 cgtgtatttg gcaatgtacc gttttgcgcg cacattgtca ttcccgtttt caccggcaag 3587761 agcgccgcgc tgttttttca ttttatcggc tacctgccat gttcggatga tcacttcacc 3587821 gacccgcccc atcgcttggg aatccgatga tgtcatgctg atcgcaccta tatcatggag 3587881 aatatcctcc gcggcaatcg tcgccgccct gattctggaa tggctgaatg ccacatcttc 3587941 aggcactttc gcatctaaat ggtggcagac catcatcatg tcaagatgct catccatcgt 3588001 attaacggta taaggaatgg ttggcgttgt agatgacggc agaatgttcg cgtaagaggc 3588061 gagcttcata atatccggag cgtgaccgcc gcctgcccct tcaatgtgat aagtatgaat 3588121 aacccggtcc ccgatcgcgt cgagcgtgtt ttccaaaaag cccgcttcgt taatcgtatc 3588181 ggtatggatg gcaacttgaa tatcagcctc gtccacgact tccatacacg ttttaatggc 3588241 gcttggcgtc gttccccagt cttcatggag cttaagaccg atggcgcctg cttccacctg 3588301 ctcgatcagc ggcgctttat cggatgcatt cccttttcct aagaagccga cattgatcgg 3588361 aaactcctcg gccgcttcca gcatcctcgc catataccac gccccggacg tacatgttgt 3588421 cgctttgctt cctgtagcgg gtcctgttcc gcctcccaaa agggtcgtca cacctgaaga 3588481 aagcgcaact tccatctgct gaggacaaat aaaatgaatg tgcgtgtcca ctcccccggc 3588541 tgttaaaatt ttgccttcac cggaaatcac ctctgtcccc gctccgatga ccatgtgcgg 3588601 atcgactcca tccatgatat caggatttcc gctttttccg acaccgacaa tccggccgtc 3588661 tttcacaccg acatccgctt tgacaatgcc tgtgtaatcc aatagcacga cgttggtgat 3588721 aaccaaatcc aaagcgccgt ccttccctgt gattctgccg ttttggccca tgccgtctcg 3588781 gatagttttt ccgccgccaa agatcatttc ttcaccgtat actgtgaaat ccttttcgac 3588841 ttcgatccat aaatccgtgt cgcccaatct gattttatcg cccgttgtcg ggccaaacag 3588901 ttccgcatat tcctcccgtg acattttcat cggattacac cctccatcca gccggcttgt 3588961 tttaagttgg ccaacgtttt ttctttgccg cgttcatcga taaacgtgtc ggccattccg 3589021 ttcagccctc taattgtctt gcgtcctctg atttccacta gtgagaccgt tttctgctct 3589081 cccggctcaa aacggaccga cgtgcctgat ggaacatcaa gacgcatgcc gatcgccagc 3589141 tcacggtcaa ataataaagc cccgttggcc tccgcaaaat gaaaatgcga accgacttga 3589201 atggagcgtg atccggtgtt ttttaccgtt acctcccgta tctcacggcc ttcattaatc 3589261 gtaatggttc cctcagcaat ttgaaatgct cccggcttca tgacttcacc tccgcagaaa 3589321 ttggctgatg taccgtaaca agctttacac catccggaaa tgtggcctcc acctgaatgc 3589381 tgtccagcat ctcaggcaca ccctccatca catctttttc cgttaataca tggcggccgg 3589441 cttccatcag ctctgctact cccttcccat cacgtgcgcc ttccataata aagcaggtga 3589501 tataagcagc agcctcagga tagttcagca gaacgccccg cgcctttcgc tgtttggcta 3589561 attcccccgc tgcaaaaatg agcaatttct cttgttcaac tggtgtcagt ttcatctgta 3589621 gtcctccttc ttttgtcata taaagcagat gcggctacta cgaatttgcg gaacagtcag 3589681 gcgggacatc acctcccttt cttcgagaat gggggtcata cggtaagatg cctttcaaag 3589741 cggcatgccg tttcttcatc agccttgcca tggtcaacaa ccgttcccct gtcgatcacg 3589801 gaaagatcag attaacgcgt tttccagact gcgctcgact aagataacaa atgtcttttt 3589861 ttctggaaat ttctataata acttgtctga ctagttcgac aattaaaatc tgaattcctt 3589921 ccaattgttt attaagtaaa atatttttca gatttaccat cagcgctctg gtgattgcaa 3589981 gctgctgctg ttgaccgcct tttcgttttg aacaaacgtt tgattaaaac aaatagcccc 3590041 ctctgtttag ccggagtcgg cctaatacag cgacaatctg ccccgggcga agctaaggct 3590101 gtgcaaaacc atcgattgat cataaccaga cgttacattc ctgatggcag cccgttgttt 3590161 tgctccgcaa ccggaagcat ggcatggagg ccagtctgag gcgccgacct ccacgatacc 3590221 gagaacccga ctattgccat taactccgca tcatggacgg tcacttcgct gatcgccacc 3590281 gttcctctta atgagtgaag aattccggcc ttcactgaat ccccgcttgt gtcgatatca 3590341 actgttttct cgcactcccg tggcttccga cactttcttc ggtgcagtac attccgtcat 3590401 caaaacccct ttgtttgatt tcttcaaatg atgttataaa agtttacaac ttatgtcatc 3590461 attatataga agaggcctat taattcaaag aatatttaaa aaatttagtt accttgacca 3590521 aatcagcttc tttttttgtt atatttattc acatcagaaa aagcgaaaaa aaagacaaga 3590581 aacatttcgt ttcctgcctc ttccgtacga ttaatcttta tctgaaaatt tatccttggc 3590641 tttcccgata tccttttgga tttcgccttt tgccttatct tttttgcctt cagcctgcat 3590701 gtccgttctg tcagccatat ctccgacttt atccttcact tctcctttgg ctttattgaa 3590761 gccgcccttc attttgtctt ttacactatc gttacccatg ttaattctcc cctctcaatt 3590821 atgtgtgtac ttgttaactt cccgatctga gaggcaataa acattctaat gttatttatc 3590881 gatttcgtag cgctctccgt aacggagcac cttgtatatc gccagcccgt ctgatgactt 3590941 tttctccgaa tatcggaccg gcagcagggc aaaaaacaca taatacgtag aaaaatagac 3591001 aaactgatag aaaaacacat tcggctttaa tacactgtgt ataatcagca gattgattgc 3591061 aaaaatcgtg atgaggttaa acaagcagcc ccctgcatac acgagtgcat ttgagaatcg 3591121 attgtcaatt ttcaactccc cgtaccggca aaaagaatcg ataaaataaa tcgttctgaa 3591181 ccgtatgggt ccaattttaa gcagcgtttt tcccatgcct atatccaacg atccctttcc 3591241 gccaaaaata aaagccataa agctgtgccc tgaaacatgt ataatctgta caagcggcag 3591301 aacaatgagg aaagaccaca gaaacttcac catatcatta aaaccaaaca ttgaattccc 3591361 cctcacatgc atatctgcat cccaaaacgg cttttgttca aaaaacagtg ctgtagcgat 3591421 ttttcctgtt ctccccggaa ataaacgttc cgatgctccc ctttttttgc ataaaaaaaa 3591481 accatctgcc agcagatggt tttgtctcat acttcatata aacaatcgtt cctttgaatc 3591541 atctctctca tgctgaccgc tttttcataa aaatacaccg cttctttata ttgttcgcga 3591601 tgactgaaat aagaggcagc atctaaagca aattcttcaa tatatacata caggcccttt 3591661 tcttccatat aatcaaatac ttcttgaatc atattcaaat tgacagattc cacatataat 3591721 gcctgcagaa atttatattt tgccagactg aagaagtcgt ttcgtttttg ggcaatggca 3591781 atcccttttt catagtaccg tatcgcggct tcgctatctt gttttttgaa aagaacgcga 3591841 gtcaggctga agagcgcttt tggaagctgt tccagctgat aatcctcgaa gacaggaagc 3591901 gctttttcaa agtattcggc ggcctgatcc agctccccct tgtcatcata gcaattacca 3591961 atattataaa gggctgatcc gatcaaacgg ggctgtcctt ccaataaagc aaggcgatac 3592021 gcgtcatcta aatgttcaag cgctttttca taatttctgt agtcaatgta gtttcctgat 3592081 atgacgaaat ggcattgaat tcttctgact ctgtaaaaat cgtgagcctt atacgtctcc 3592141 agcgcctgta cggcatggtt catggaaaag tgcgtctgct tcataatata aaagacttcc 3592201 gccactttaa aatgaaattc cgctctttca atttcatctt ctacaaacgc aagcatcttc 3592261 tcagctttcc gataaaagga tatagccgag atgtaattgt tctgttcaaa ttcgtacatt 3592321 cctctaaaca agtgaaaata atactcagat aatccggaga tgctgtcctg attgctttcc 3592381 agcgttttga tcaattcacg atattgaagc tgagattcct cgtgcaggtc aggctttaca 3592441 taatccagca taatttggtg ccggtagctg atcagctgat aatacaggag aagcagctga 3592501 tcctcttcca tctgttcgat atctagatca atttcttctt tcagttttac ggcatcagcc 3592561 acttgaaatg ctaaaatgtg cttataccac ttattgattt tcactcctac ttgagatgac 3592621 gggatctcgt acgcggccat gcccctccaa ccctttctat tttctaattg gttatatttt 3592681 atcataatgt atggctttgg aattaaattt tcttacaatg attccttctt tatgcctatc 3592741 cttatatatt tcggtttttc tacgtatttt ttgcactcgg attctaataa aaaagcttac 3592801 cggacagtgc cgataagctt ttgacttcaa attaaccgcc aatataagac atttccactt 3592861 tctttttgcc agatgctttt gatagcgtac gatcgactga atactgatcg atccgatttt 3592921 tccatactgt cccgatcatt tctgatagtt cgtcatcact taattcctgg cgaaccggag 3592981 ctctgaggtc aaatccgctt gaagcgaata agcaggtaaa cagctctcct ctcgcagaaa 3593041 gacgggctct gttgcaagat ccgcagaatg catcagatac agatgatatg acgccaattt 3593101 ctccggagcc gtccaagtag cggaatctgg aagccacttc gcctatataa ttaggcgcta 3593161 tcggctcaac cggcatgtgt ttattgatca aatctatgat ttccgccttt gtcatgacgt 3593221 ctttcttttc ccattggttg gtgttgccta cgtccataaa ttcaatgaat ctcaggatat 3593281 gccctttttc tttaaaataa cgggccatag gcagtatatc tttttcattg acgccctttt 3593341 gaacgaccat attgatttta acaccgagcc ccgcttgctt cgccgcttca atgccttcca 3593401 gcaccttgct gacagaaaca ccgcgcccgt ttatcttctt aaaacgctcg tcttctaaag 3593461 aatcaaggct gatcgtaacc cttttcagcc cagcctcctt gagcctctta gcataaacag 3593521 gcagcagtga tccgtttgtc gtcatcgcga tgtcacgaat acccggtatg cgggccagtt 3593581 ttttgattaa ttccggcata tcctttctca tgaggggctc tccgccggtc aagcggattt 3593641 tttcaacgcc aaatcttgtg acaaacaatg tcgcaagccg ttccagctcc tcaaatgaaa 3593701 gcagctcctc tttctttaaa aaaggataat ccgggccgaa taattcggcg ggcatacagt 3593761 acgtgcatcg gaagttgcag cggtctgtaa cagaaatgcg aaggtctctc agcggtctgt 3593821 ttcttttatc caacatctga cgcgactctg taatcatagc tacagcccct tcctactccc 3593881 tgattctctc agggtgtgta tatacattaa atgatccgtt tctgacaaat ccaatcgctg 3593941 tgatattcaa ttcttcagcc atttgaatcg caagctccgt cggggccgat ttggaaatga 3594001 caatcgacac gccgattttg gccgctttta acaggacctc tgatgagatt ctgccgctga 3594061 acacaatcag tttgtcgcgt acggacatcc cgtttagaag gcagtgtccg tatagtttat 3594121 caagtgcgtt gtgccgaccg atatctgtgc gcatcaacag aagcttctct gtgtcgcaaa 3594181 gcgccgcatt atggacgcct cccgtatcct gaaacgtccc gctcccttgc tgcatgtctt 3594241 tcataagcgc cagacatgcc tcaggcgata tcttgatttg gctgacagcc gtcttggctg 3594301 ttttgacatc ctgctgaaaa taaaaatgac ggccctttcc gcagcatgag ccgatcaccc 3594361 gtttcgtata atccttttga tccaatgtct cagggtgaac gaggtcgaca tatacaaaac 3594421 cgagactttc atctattgta aaccttttaa tttctttttg aaatcgtata acaccctctg 3594481 atgcgagaaa tccgatgaca agctcttcga tatgctcagg cgtacaaacg agcgtcacaa 3594541 attcactgcc attcagtatc actgtcaaag ggaattccgt caccatccgg tcttctactt 3594601 tgcttatttc cccttgttca tagcgccata catccctgac cgcagttact ttatcgttca 3594661 atgtctcttc ccctccgcaa tgttcctgcc tttatatttt ttcacactcc tcggattttg 3594721 tcgaattctg agacacaaaa agagccctct atataaaggg cttttacagg atgtgatgac 3594781 ggcggtgttt aggcaggacg cctaagcatt tagccgccgt tccttttata acacgtgagc 3594841 accaatgtgc attgacaacg aacgcggggt ttgtcgacac gctgagacac ctctgtataa 3594901 aggactctat gtttgattat gctgattctt tttcagaacc gtaaacagca caatagctgc 3594961 gatcaaggtg agaatgctga caaaaaagaa ggctgccagt tttagaagaa caccaagcaa 3595021 tataaatgca acggtggcta taagaaaaat cattccgaat aatttcatat gttcaacccc 3595081 tttttagggt atcattcccg cccaaactgt ttttaaacca ataaaaaagg cgcctggggg 3595141 agcgcctgat ctttaggttc cttactcagt aaatttttgt gcttcttttt cccaagcctg 3595201 ttcgaactca tccgcactgt tcgctgaaat atattctccg ccgccagcga cagctgcttg 3595261 tttcatctct tcattaccct tgacatcaaa gttgaagcca atgatgttta caatcgtatc 3595321 cacatttgat gcacggagct tttcgatttc cgccgcaggg tctccgccgc acgtttcttc 3595381 accgtcagtg attaaataca ccacgttttt cccgtctgcg tcaaatgctt caaattcttt 3595441 tcttgtgtct gcaagtgctt tggcaatcgg tgtccatcca gtcggcttga gctcactcaa 3595501 tgaattgtca aacagagacc cttcatatgg atgaaggccg taaatggttt ccgtcgtact 3595561 gcacgaaagg gctttaccgg acagtttatt gttccctgca tgcccgaaaa cgcgaagcat 3595621 aagatttgta tcctttggaa gaagttcggc aaaagatttt actgattttt tggcaatgtc 3595681 tattttgcgc tctcctcctg ttttttgaac catgcttccg cttccgtcaa acaaaacagc 3595741 tacatttgta tcagcctgtt tctcagcggc aaaagacggg gaggcaatgg aaacagtcaa 3595801 caatccaatg ataccggcag ccagcaattt tttcatatga ttacttcctt tctttttcat 3595861 attttccaac tatatgttgg attcttcttt atgctagaat acgaaaatgc aaaaagatat 3595921 aggacatgct gccttttgtg ctgctttcac gatctgtcca aaatcgcttg aaatgccgtt 3595981 catttttagc catttccgcc cagaaagcat aaacagcttg tgtgatcatt cattcttttt 3596041 tcgccttgat tatgacagaa aaacggaaat ctgctactat gctacaggca gacagctaat 3596101 tagttttgaa gtttttgtta catacaaaaa gaggctgacc atcaccagcc tcttttttct 3596161 tatttagata acattagtga ttgctgagtg aaaattttct caacatcttt ttgggtataa 3596221 gccgggaagt attcaccgcc gcctactttc gcaattgcgt tcagctggcc tttgtatccc 3596281 tctttataat caaagccgat cacattaaca gtgatattgt ctttttgcag ttcctttgct 3596341 gttttaatcg ggtttcctcc gcacgtttcc tcaccgtctg tcaacagata caccactttt 3596401 tccccttttg catcaagctg gtcaaaagaa gatttcgcct cgttcagcgc tttggcaatt 3596461 ggcgtccagc cagtcggccc aattgtattg agagaattga ggaagctttg ctcgttaaag 3596521 ctttggaagc cgtatacgtt gcgaatggct tcacatgact gaacttttcc ggaattttta 3596581 ttgtttcctt cagagccaaa cacgctcatt ttcacctgag ttccttctgg caatgagctc 3596641 gcaaactttg aaatttcttt tttggctgaa ttaaatttag atacaccatc tattcttttc 3596701 gccatacttc cgctggcatc aagcaagacc gccacgttcg ccggcgcttt agcctccgtt 3596761 tctgtctttt cagctgcaaa agcaggtgaa gttaatccaa aaagcaatcc tgtcatcatg 3596821 atcagtgaaa atcttttctt catgttcgta cccctttacc aatttgtttc tgcgtgcaga 3596881 tgttcaacgc tgaacataat ctatcgtaat caacaaaaac cgagaaataa atagggcggg 3596941 cttccccatt gctgttgttt acttttgcat agaaacctat gtttttatta gtgatttcca 3597001 cctaacgccc ctatgaaaag agaagattgt ccgcctttcg gctttcgtta tatgagtctg 3597061 tcgaagtctg tcgacaaatg tggatgactt taccacaatc tcaaagcctg aaatcaggaa 3597121 aaaaggactg atccttaaag acggtcagaa gctcctctaa accgtttcag ctactcttag 3597181 ataaaagata ttcaggaaca gaaaaagacg cccaatgagc gtctttttct actttttcgc 3597241 catatattta ttcaaaaacg catctgcctc agaaatttgt gtgccttggt aatagtactt 3597301 tacaatgtca tcaaccgttt tgccttcttt ggccataaaa ttcgctccgt attggctcat 3597361 ccccacaccg tggccaaatc ctctcgtcgt gactgtaatt gtgtctccat ttcgcttcca 3597421 ttcaaaatcg gcggagttga gacccaactt ttcacgtatg tctcttcctt tcagcgtctt 3597481 gccgttaatg acggcagttg cgacctggtg gcccggtgtc tcgccggtaa tcttccctac 3597541 tgcgctagat ccatccagct tgacgccaag cttttgctga aattctgccg ctgtaaaggt 3597601 tttcgttgcc ttatatttcg gagacttttt atcccatggg cttttgacgc tttttaaata 3597661 tgggatagca cttgtccaat aagcttctgc attctctgtg tagccgttgc ttgtggagaa 3597721 aaaggatgct tcaatcggct ggttgttgta cgttaagatt ttgccttgcg tactggctac 3597781 cgcatctgtg attttcttca gttttgtctc atagcttgtg ccccactgtt ttttcagctc 3597841 cgctttgctt ttatacacct ggaacatctg tgtatcatcc accagtgagc ctttaggagc 3597901 ttctaccgct gaatttgaca ccatcagtct gacaataaat gttctggcgg caagcgcctg 3597961 ggctttcagc gcttcaggtt taaaggttgc cggcatttcg gaggcgacga ctccaatcac 3598021 atactcttca agcggaatgt tttctacgga ttgatttgcg gttcgataga cgggaataga 3598081 aacaggtgat gctttcaatg tttctgctcc tttcgatgct ggtttcgtgc tgactgctgt 3598141 cttttctgat tctacgctgg cccccgcttc cttattatgc tggaatggta taaccaagag 3598201 tgtgggaacc aagagaatca atgcacatag tacggatagt gtgattgcga attgtttcat 3598261 attcagctgc ctcctgctcg ggattcgact ctagtctagt ctatgggcag ggacaagcta 3598321 atatgactct cgttttggac agaaacttta tttgtcattt acgtattctt ttttgctatt 3598381 ttgcgcataa tgatgataat acacaaaaaa taaaaaacca gtatgccaga gtgacatact 3598441 gattttcaag taagtttatg catttaagtc agaaacgact tctttattct cttgctcaga 3598501 agcagactca tcatttacac gttcgatgtc tgcgcccaga gcggcaagct tctgatggaa 3598561 atcaacgtaa ccgcggtcta agtgcttcaa ttcagtaaca cgtgtgtgac cttcagccac 3598621 taaccccgca agaatcagcg ctgcacctgc acgcaaatca gtcgctgcaa cttcagctcc 3598681 ctgaagctgt acaggaccgt taatgatgac agaacgtcct tcaatcttga tatcaccatt 3598741 catacggcgg aattcttccg catgcataaa acggttttca aaaacggttt ctgtaatcat 3598801 gcttgtgccg cttgcacgaa gcagaagcgc catcatttgt gactgcatat cagtcgggaa 3598861 gcccgggtga ggcattgttt tgatgtcaat cggtttaagc tctttcgggc cgatgacacg 3598921 cagaccttca ccttcatcct taattgttac acccatctct tccatttttg caattaaaga 3598981 ggtgaggtgc tcaggaaccg ctccttttac taatacgttt ccttcagtga ttgcagcagc 3599041 aaccataaat gtgcccgctt caatacggtc aggaataata tggtgtttta cgccgtgaag 3599101 cttttcgact ccttcaattt tgatggtgcc ggtgccagct ccgcggattt ttccgcccat 3599161 gccgttgata tagtttgcta aatcaacgat ttcgggttct tttgccacgt tttccagcgt 3599221 tgttgttcct tcagctagag cggctgccat aatcaggttc tctgtagctc ctacacttgg 3599281 gaagtccaga taaatttttg cgccttgcag tcggcctttt acttcagctt caatgaagcc 3599341 attaccgact ttgatttctg cgcccattgc ttcaaaacct tttaaatgct gatcaatcgg 3599401 tctggaacca attgcgcatc cgcccggaag tgcaactctt gcatgacctg tacgcgcaag 3599461 aagcggcccc atgacaagca cagacgcacg cattttacga acatattcaa aaggtgcttc 3599521 agtttgcaaa gcgtatgaag catttacagt cacttcatta ttttcaaaat gcacatctgc 3599581 tcctaaatga cgcaacactt cgttaattgt atatacatcg gagagcgtag gtacatcaca 3599641 aattacgctt ttttcttcac ttgctaataa agatgcagcg ataacaggta aaacggcatt 3599701 tttagcgcct tcaactttga ctgtgccgtt taacttctga ccgccgcgga cgatgatttt 3599761 ttccaaggta ttcccctccg cgtccctaaa ttctctatat taatattcag tcgtaacgat 3599821 tggtgtgcca accgtaacgg tatgttttcc gcccattcct gcacttctaa gtgcaatttg 3599881 caaattcatt ttatgtttcg aggtcataat gtactcttcc cactcatctg taaacgcaga 3599941 aatagaaacg aaatttggct caactacatg ttctactgat cttgcttgaa attcatttaa 3600001 taactgattt gctttttttt gcaaaacaat attcatatta tcatctaagt gaccatttag 3600061 acaagtaaaa ataactactt tttcttggaa tatcccaagt gtctcccgtt caaactgttc 3600121 atatgtatca ttccagctat ccggtgtctc tagactcatt tgctcatata ataaatacga 3600181 agttggattg tgttttttga gggttgtgac aagctgcagt ctaaaagaag tacgattttt 3600241 tttgtcagta tatgtgccaa ttgcctttat cattttatct tcccgtgcaa tcacccaatc 3600301 atattgacga tactcttgtt ttaaacgttg cactttttga taaaattctt tttcggtcag 3600361 tgacaagttt tgttttgcat gcaatgtcca cttatctatt gacacatctt gacgttccat 3600421 cccctctgcc atctgtgcta acggcgttaa ttcactcgca tgaatggtat ggaaaacagc 3600481 aatgacgaag cttaacatga cggaaatgat aatagcgtgg cttacttgtt ttttcttcat 3600541 gttcatctct cccccttatc cccagtttta ccggaggcaa gaggcgccat acgtaaaaat 3600601 cttcgtcaaa actcgagcta ttcgcttcaa cccgcttctc ccaaccattt aataatgttc 3600661 aaaacctatt aaaatagata gggaagctgc tgtgaataat tgaggtaatc taaaaagaaa 3600721 ttggcaacgg ccgttccaat ggcgattgtc agcaaaatca tcaggagtct tgcctgcacg 3600781 actttgcctt ttttgattaa cggatctata ttgacggctt gcaacgccca ccaagtcact 3600841 gctataaaaa tcaggtgaac gacaatgccg attgcagcct gctgtcccaa tacactcatc 3600901 tattacactc ctttctctgc gttcataccc tttcttatta tataagaagc acagataaag 3600961 atgatacatt ttatacagaa cggaataatc agccaaatct agggctaatc cccgcttaaa 3601021 gtgcgattct tttacatggt atactttatt ggaaaggagc tggcaaatgt gaatcattct 3601081 ttttttcagc ctgaaaagca atatggtgag gacctgccaa tttttgatca ggaatgggaa 3601141 gcaattgcat tctattatga ttatagacag tcacagattg aagaactgaa tgaattgtgt 3601201 cagtttttta acatttctct tacctatacg agagaaagcc ttgaagagct tgaaaacctc 3601261 tattttcaaa gtatacaaga acttttgctt gctgattgga atcttcctat tgaagaattc 3601321 gagaaaatga tcagtgttta tcttatagat tgtgtgattg cccgccatga agatgctgaa 3601381 tgggttgtaa aaccttatcc ctataaagac ggcgcttata cacttggctt tagaagacat 3601441 cgcaaatcgt ggcatacaat gaatgcctgt gatggtttat acctgcgtcc aaaagaggat 3601501 cgcccgttgc tgtcgctgtt tgattctctt gtgcgttcat aaaaaaatcc ttctcataaa 3601561 gagaaggatt ttttcttatt tccctgctac atccaatctg ttcaaagccc gctgtaacgc 3601621 aagctcagcc cgacgaatgt cagtatcatc tgattgagaa ttcaaacgct cctgcgcccg 3601681 ctggcgtgca gcttcagcgc gctctttatc gatgccttcc gctgtctcgg cagcctgggc 3601741 aaggatggtg acatgatcag gacggacttc tacaaaaccg ccgctgacgg caaccatttc 3601801 agtctgcccg tcttttttca gacggacagc gccgatttta agaggagcca cggttggaat 3601861 atggcctggc aaaataccga gatcgccgct ttcggctctc acactcacca tttcgatatc 3601921 cgcatcgtat actgggccgt cgggagtaac gatattgact ttaacggtct tcatgctttt 3601981 accctcctag gaccagatta aacttctaca cccatttctt ttgctttctc aacaacttct 3602041 tcgatacggc ctacaagacg gaatgcatct tctggaagat ggtcatattt accggctaag 3602101 atttctttga agccttgtac cgtctctttt acaggcacgt aagaaccttt ttgtccagtg 3602161 aactgttcag ccacgtggaa gttctgagaa aggaagaact ggatacgacg tgcgcggtga 3602221 acgacaagtt tgtcttcctc gcctaattca tccataccga gaatcgcaat gatatcctga 3602281 agctctttgt aacgctgaag cgttgactgt acttcacgcg caaccgcata gtgctcttct 3602341 ccaacaattt caggagcaag ggcgcgtgat gtagatgcca acggatcaac cgcagggtaa 3602401 atacccattt cagttaattt acgctcaagg tttgttgtcg catccaagtg agcgaacgtt 3602461 gtcgccggcg ccgggtcagt gtagtcatcg gcaggcacgt agatcgcctg gatagatgta 3602521 actgatccaa cgttcgtaga cgtgatacgc tcttggagct gacccatctc agttgcaagc 3602581 gtcggctgat aaccaaccgc tgaaggcata cggccaagaa gggctgaaac ctctgaaccc 3602641 gcttgtgtga aacggaaaat gttatcgatg aagaacagta cgtcctgtcc ttgtacatca 3602701 cggaagtgct cagccattgt aaggcctgtc aaagcaacac gcatacgtgc gcccggcggc 3602761 tcgttcattt gtccgaatac catggctgtt ttgttgatta cgccagagtc actcatttcg 3602821 tagaaaaggt cgttcccttc acgagtacgc tctcctacgc cggcgaatac agagataccg 3602881 ccgtgctctt gcgcgatgtt gttgattaat tcctggatta atacggtttt acctacaccg 3602941 gcaccaccga acaatccgat tttaccgccc ttaatgtaag gagcaagcaa atcaacaact 3603001 ttaatacctg tttcaagaat ttcaacttct gttgaaagct gatcgaatga aggcgcctgt 3603061 ctgtgaatcg gatccttttt cgcatccgca ggaaccggct cattcaaatc aatattttct 3603121 ccgagaacgt taaatacacg tccaagtgtt acatcaccaa ccggtactga gattggcgct 3603181 cctgtatcta cagcttccat accgcgctga acaccatctg tagatgccat tgcgattgta 3603241 cggactgtat catcacctaa atgaagagcg acctcaagcg ttaaatcaat acctacttcg 3603301 ttttcacttg cagctggctg tgaaatttta atcgcattat aaatttcagg caagtgaccg 3603361 tcttcaaaac gcacgtcgac gaccggtcct aatacctggc taacgcgtcc tttcttcatc 3603421 gctatccctc ctgacaaaat ctttctattc taaagcggct gctccgccga caatttccgt 3603481 aatttcttgt gtgatggctg cttggcgagc gcggttgtaa gaaagcgaaa gtgaatcgat 3603541 aagttccttc gcgttgtctg tcgcgttttt catcgccgtc attcttgcag cgtgctcact 3603601 tgctttactg tcaagaagcg caccgaagat taagctttct gcatattgag gaagcaaaac 3603661 ctccagaacc tcctcttcag atggttcaaa ttcataagac gccgttcttt ttccgccgcc 3603721 gctgcccaaa tcagataacg gcagaagttt tttctccgtt acttcttgag taatggcgct 3603781 gacaaaatgg ttataaacaa ggtgcaattc atcaaacgca ccgtctataa acatttgaat 3603841 cgtttgacgg gcaagatctt taatttctgt aaacgttact tcatctccaa gtcctgttaa 3603901 ctcggaaatg atcggaatct cccgtttctt aaagaaatca cggcccactc ttccgatggc 3603961 aatcaccgca tactcatcct tagactgatg acgttcttgc atggcctgat aagcactccg 3604021 taaaaccgaa ctgttaaaag cgccggcaag accgcggtca gacgtaatga caaggtatgc 3604081 cgtttttttc acttctctgc tgagaagcat cgggtgcttc acgttgccgg aaactcttcc 3604141 gacgtttgac acaacctctt ggattttatc catatatggc acaaatgatt ttgcattgtt 3604201 ttcagcacga ttcagcttag ccgcagatac catctgcatg gcttttgtaa tctgacttgt 3604261 ttttttcgtt gacgtgatcc ttgacttaat atcgcgtaat gaggccaaag atttcaccac 3604321 cttttctctt catctgcgta aaaagagaga aaaagagaac ctttttctct catcagcatt 3604381 cgagttagtt gcttggtgca aatgtgcgtt tgaagccttc gattgcagct ttgaagtctt 3604441 catcagcagg aaggtttcct gttttcgcaa ttccgtcaag caggtcttta tggttttggt 3604501 caaggtacat gtagtactct tcttcaaaac gtctgatatc cgccacagga atatcatcga 3604561 gatatccttt tgtcagcgca taaagaatag ctacttgctt ttcaaccgga agcggcttgt 3604621 tcagatcctg cttcagcact tcaactgtac gcgcaccgcg gttcagtttt gcctgagtcg 3604681 cttggtcgag gtcagaaccg aattgagcga atgcttccag ctcacggtat gacgcaaggt 3604741 caagacgcaa agtacctgat acttttttca tcgctttgat ttgcgctgag ccgccgacac 3604801 gggatacaga caatccggca ttgatcgctg gacgtacgcc tgagaagaac aaatcagatt 3604861 gcaggaagat ctgtccgtcg gtgatggaaa tgacgttcgt cggaatataa gcagagatat 3604921 ctccggcttg tgtttctacg aacggcagag ctgtaattga tcctgcgcct ttcgcgtcgc 3604981 taagctttgc tgcacgctca agcagacggg aatgaagata gaatacatcc ccagggaacg 3605041 cttcacggcc tggcggacgg cgaagaagca aggacagctc acggtaagcg gccgcttgtt 3605101 tagaaagatc atcgtataca acaagaacgt gcttgccgtt gtacataaat tcttctgcca 3605161 ttgtaacccc agcatacggt gccaggtaca gaagcggtgc cggctgtgac gcagacgccg 3605221 ttacaacaat tgtataatca agcgcgccgt gtttacgcaa tgtttctact acgccgcgga 3605281 ctgttgattc tttttggccg atcgcaacat atacacagat catgtcttgg tctttttggt 3605341 tcaggatcgc atcgatcgca acagatgttt tacctgtttg acggtcaccg atgatcagct 3605401 cacgctggcc gcggccgatt ggaatcagtg catcgatcgc tttgataccg gtttgaagcg 3605461 gttcatgaac ggatttacgg tccataacgc ctggtgcagg gctttcgatc ggacgagttt 3605521 tgcttgtcag aatcgggcct agtccgtcaa ccggctggcc tagcgggttt acaatacggc 3605581 cgattaactc ttcaccaaca ggaacctcca tgatgcggcc tgttcttttt acttcgtctc 3605641 cctcacggat ctcactgaaa ggtcctaaga tgacgatacc tacgtttgat tcctcaaggt 3605701 tttgagccat acccaaaaca ccgtttgaaa attcgacaag ttcaccggcc atacagttgt 3605761 caaggccgtg cacacgtgca ataccgtcac cgacttggat gactgtacct acgtcttgaa 3605821 cttcaatatc agattgataa ttttgtattt gctgttttat cagcgtgcta atctcttcag 3605881 ctttgatgct cacttaggtt tcaccccttc tatcgatttt ccccggctaa ttgacgttca 3605941 atgcgctgaa gcttcccgct tacgctgccg tcataaatcc ggtttccaat gcggacttta 3606001 ataccgccta ttaaatccgt ctgcacttca tttctgattc tcagtgaagc gactccggct 3606061 ttttttgcaa acacttgtga taatggtaac atttctgcat ccgtcagcgg tttcactgaa 3606121 tatacgattg cgtcttctgt ttgacgggcc acatttgcga gtttgataaa ctcatctgtg 3606181 agctcaggga caatcgcggc acgatggcgg tcaatcaaaa gaaaaatcgt attgagtacg 3606241 gactgtgaca aagagccaaa tgcattttga atcagctctt ttttcttcgc agccggcacc 3606301 ttcggatggt tcaacacatc attaagcgct ttttcatttt gaaatacttg ttttacaaca 3606361 attagctctt cttctacttg attcagctga gcggactcat tggctatatc aaaaagagct 3606421 gatgcatatc gtttagagac agctgatcca ctcatcggct ttctcctacc tctttaagat 3606481 agtcctggat caatttctct tgcgcttgtt catccagttc tttttcgatc actttcgacg 3606541 caatcatgac agaaagagac gctacttgct cacggagagc agaaaccgcc tgttcctttt 3606601 ccttcacgat ttcagttctt gctgcttctt tcagacgttc agattctgca cgtgcagcct 3606661 gaataatctc ttctttttgc ttctctccca gtttctttgc gttttcgata agagtttggg 3606721 attcctgtct tgcttctttt aaaagaacgc gctgctcttc aatcagctgc tgcgcttctt 3606781 tatttttttc ttcagcagac gtaatttctc cagcgatgtg gtcttcacgc tgtttcatta 3606841 tgtttaatag cggccctaaa gcgtatttct tcagaagcgc taataagatt aacatagcta 3606901 acagttggaa caggatatct ccgccgttaa acgacaatcc tagttcaagt ggtaattgag 3606961 acatctacta cggcaactcc cttctgcagg tttttctttg ctgatccagc agccgcactt 3607021 gtctcttttc agccggcaag gcgggatgct tatcagacat aaagcaatgg cgaaggttct 3607081 cttggaatga tcttcgccat ttttagttca tataaggctt ttatgcttag ccaaagaacg 3607141 ctaagaatgc gataacgaca gcgataatag gaagggcttc aactaatgcg atacccatga 3607201 acataagagt tctcagttct ttacctgctt ccggctgacg ggcaatcccc tctaccgtac 3607261 gtgaaacaat caaaccgtta ccaatacctg caccaagtgc gcctaaacca attgcaatcg 3607321 cagctgctat taaattcatg aaaaagttcc tcctttaaaa tgttatccgt ttggatataa 3607381 tgttttaatg atcatgactg attttatgag acatgtacac catcgtcagc attgtaaaga 3607441 taaatgcctg gatagcacca ataaataaac tgaatgcttg ccatgccagc atcggcagaa 3607501 tggcaccgat tgtaccgaca agaccgagag ccacgctttg cgaataatgg cttgttgcta 3607561 atcccgcaag caggccgaga agaatctcac cggcgaagat gttaccatac agccgcaaac 3607621 ctagagtcag cgtattcgca aactcttcga tgattttcat cgggagcatg aatggaacag 3607681 gtcttaaata gtctttggaa tattccttga gccctttcat cttcacacca tagtagtggg 3607741 ttaaagcaac aaccatcacg gctagcgtta atgtaatggc aggatcggct gtcggagact 3607801 tccaccagag ctcatgtccg attgtaatag agaacggcag ccccagcata ttcgacacaa 3607861 atatgtacat cagcaatgtg acaccaagtg ccaagaagtt agcccctgtt tttaaatcca 3607921 ttgtactgcc aataatattg cggacgaaat caacaatcca ttccataaag ttctgggctt 3607981 ttccgggacg gatcgaaagc gttcttgtcg tcaatatagc aatcaataaa acaatcacac 3608041 tcgccacagt aatcatcaga atgtttgtca gattaaaagt aagacctaga aattctatag 3608101 ttctgtaacc atgattcaaa gggttttcac ctctcttcca ttgatgaacg tttaagctgg 3608161 ataaaggaat ctatcataat gacagggtat attgtcatta atccaataac tgtacttgcc 3608221 atatgaaagt attcgggatt tttataggca acagccacag caagaatcgc attgcaccac 3608281 cgcgctgcgc tcccgagaga tcgtatggac tttcctttct ctacagctct gtcaaaagca 3608341 ttcattcttc tgacgagcag taaaaaatta aacaaactga aaacagttcc cagaataagg 3608401 cctaaaaaaa cggttttata cgctgttaaa ccataaccca gtacatacac tgccaaaatg 3608461 aacaataaat atttgcgttg tctgctaaat gtaagcttgg gatcgtccat caattatctg 3608521 tctcctgatg aaaaaataat gtatagcttg gatacggcaa aaatcagcgg ttaaccctta 3608581 gtagaagacc ttttttgacc ggcaaaacgg gcctgttcga aaaaatcatt catccgcaag 3608641 ccttgcaggg atgctgtttc attcgcttaa ataaatcctc ataatacggg tttgctgaga 3608701 ggatttacat tgaggatgag gactataatg aaagctatga aaaccttctc ataataccct 3608761 cgtttagcat acaatagccc ctaacatgtg tcaatctgtt taaagttaaa aaacttttta 3608821 tactttacgt ctccacagaa tgttcacatt ttcacctata attgtataca gattcaccga 3608881 atagcaaaaa actggataaa aaaatgaaac ccccttttgg ggatttcatt ttttattttg 3608941 ttccaaacat gcggtcaccc gcatctccga gacctggaac aatatatcct ttttcattta 3609001 atttttcatc tagcgccgca atgtaaatat caacgtccga atgatgcttc tgcaattctt 3609061 ccacaccctc cggcgctgct acaagacaca tgaaacggat atttttcgca ccgcgttttt 3609121 taaggctgtg aatggcttca actgcggaac cgcctgtagc gagcatcggg tcaaccacga 3609181 tgaattcacg ctcttccaca tcagaaggaa gcttgacata gtattccacg ggttttaagg 3609241 tttctggatc acggtaaagg ccgacatgtc ccacttttgc cgcaggaatc agctttaaaa 3609301 tgccgtcaac cattcccaat cctgctctga ggataggaac cactccgagt tttttccctg 3609361 agatgacttt cgatttcgca gcctgaaccg gtgtattgat atccacttct tccagaggaa 3609421 gatcgcgggt aatttcaaat gccatgagtg tagccacttc atctactaac tctctaaaat 3609481 ccttcgtacc tgtattttca ttccgtatat atgtcagctt gtgctgaatt aaaggatgat 3609541 caaatacata aacctttccc atactgtgtt tcagctcctt ttttattgtc ccatcaacaa 3609601 ttacacactt ctattgattc tacaaaaaaa gacattgagt ttcaagaaca tcgtcaaaaa 3609661 acccgccggg cataagccca agcgggtttt aggatcttaa taatctaatt ctttatataa 3609721 aggaaattta tcagtcagag cagctacacg ctgtcttgct tcttcaagtt ttccttcatc 3609781 ttcgtggttt ttcaatgcaa gcgcaatgat agcaccgact tcttctaatg cgtctccgtc 3609841 aaaaccgcgg ctggttacag cagctgtacc aagacggatg ccgcttgtta cgaaaggttt 3609901 ttcaggatca tatggaatcg cgtttttgtt agacgtaata ccaatttcat caagtacatg 3609961 ctccgcaacc ttaccagtca gtccgagcga acgaaggtca acaaggataa ggtggttgtc 3610021 tgttccgcct gaaacgagct ggatgccctc tttcgttaag gcttcagcca gacgtttcgc 3610081 gtttgaaatg acgttttgtg catatgtttt gaaatcgtcc tgcaatactt caccgaatga 3610141 aacagctttt gcggcaataa cgtgcatcag agggccgcct tgaattccag ggaagatcga 3610201 tttatcaatt ttcttgccaa actcttcacg gcaaaggatc ataccgccgc gaggaccgcg 3610261 aagtgtttta tgtgttgttg ttgtaacgaa atcagcgtaa ggaaccgggt ttggatgaag 3610321 gcctgccgca acaagtcctg cgatatgtgc catatccacc atgaagtaag cgccgacttc 3610381 atcagcaatt tcacggaatt tcttaaagtc gattgtacga ggatacgcac ttgctcctgc 3610441 tacgataagc ttcggtttat gagcgagggc tttttcacgc acgtcatcgt aatcaatata 3610501 ttgagtttct ttatctacgc cgtactcaac aaagttatat tgaacaccgc tgaagttgac 3610561 tgggcttccg tgtgttaaat ggccgccgtg ggagaggttc atcccaagta cagtatcgcc 3610621 ttgctccaaa atcgtgaagt acactgccat gtttgcttgt gcgcctgaat gaggctgaac 3610681 gtttacatgc tccgctccaa agatttcctt cgcgcggtca cgggcgatat cttcaacgac 3610741 atcgacgtgc tcgcatccgc cgtagtagcg tttgcccgga tatccttctg cgtacttatt 3610801 tgtcaaaaca gatccttgtg cttccataac cgcttcactt acaaagttct cagaagcaat 3610861 caattcgatc ttagtctgtt ggcgttcacg ctcattttta atggcgttaa acacttgttc 3610921 gtcttgcgca ggtaaatgtt tcatcagcga gatcctctcc tatccgtatc ctgttctttg 3610981 tttttaccat cactattgta catggttttt aaggccgatg taaaagatta tttttaaaaa 3611041 atctaaattt ttattggtaa aaacgaatat taataactta aatttaattt aaagttcgga 3611101 atttatttca ctatcttaaa ataaaagaaa agactggcta tgcagtcctt tcattcgcac 3611161 tcataaaccg cccgcactcc gccgattagt ttcggccgtg tacgcgccaa tgtcacatga 3611221 gctgaaccga ggctgttttg agagacacgc acagggacag ccaccggttt cagatgcatg 3611281 ccgataaacg tatcgcctat atcaattccg gcgtcagcct gaatggtttc aacaagaaca 3611341 ggagacttca tctgcttaaa cgcataagac gccatcgctc cgcccgcttt tggaacgggc 3611401 acggcagaaa cggttggaag cctgaacagc ttggctgttt ctgcttcgac gacaagcgct 3611461 ctgtttaaat gctcgcagca ttgaaacgcc agatggattc ccgttttttc ccggagctca 3611521 gcaagtccgc tgtagatgct ttcagcgata tctacactgc ccgatgtgcc gatccggctg 3611581 ccggccactt cgctcgtgct gcatccaagg acgaagagct gatcttgttt caattccgct 3611641 tggtcctgaa actcagacag catcgtcttc cacgtttgtt tcaactcatt cattaaacag 3611701 cacccctaca ggtttttctc ttcataatcg gagatttttc caatacgcgt ttggtgtctt 3611761 cccccggtaa actcagtagt cagccagatt tttgcgattt cccgagccaa accaggtccg 3611821 atcacccgtt cacccatcgc aaggatgttt gtgtcattat gctccctcgt cgccttcgcg 3611881 ctgaaggtat cgtgcgccag cgcgcagcga atccctttta ctttattagc ggaaatgctc 3611941 atgccgatgc ctgtcccgca aattaaaatg cctctgtcaa cttcgccgct aaccactttt 3612001 tcggccaccg gaaaagcata atccggataa tcgacagagc cgctgccgca gtcacagccc 3612061 atatcaatat attcaatttg caattcgtcc attaactctt tgatttcatt tcgaatgtga 3612121 acgccgccat gatccgatgc aatggctact ttcatctgct tttcctccca gcgtgtgtga 3612181 tgcggcccgc ccgctttatt gaccgcgcag cctgtccgct ctttgattca caccatatga 3612241 tgtgcttttc actatattct actccttcac gcaggatttg caaatgacct gtttgcagat 3612301 tttctgacaa cttatctacg gtcttttttc agctgttttg ccagctgccg aagaagctct 3612361 tcaagctcat ctcgcgtttg tttatagatg tcaattgagc cgccgaacgg atcgaggaca 3612421 tcaccatggc tgcctgtgac atattctttt aacgtaaaca ctttatcacg ataacgtcca 3612481 aattggctgg caatgatctg tttgtgctga tgggtcatag ccagaaccaa atcagccgat 3612541 tccataagtt cttcagttaa tggagaagac acatgattaa gggcaatgtg tttttcaaac 3612601 agcgcttcga ctgcatgagg cgtcgctttc ccattaggtg aagcaaacac gcctgccgag 3612661 cggacattga cattcagccc ttccctttct gcaattgatt taaaaagcgc ctcagccatt 3612721 gggctgcggc acgtatttcc agtacagaca aaaataatat ccatgtcagt caccccttat 3612781 ttttctctat tatatatgaa gaaaaaagaa acggcgactt cgtttctttt attggtatat 3612841 taaattggca aaagcagctt taatccaaac acgattaata tgatgccccc gagcgcttcg 3612901 ctgtatgtgc caagccatga ctgcacttgt tttccgacca gcaggcccag ccatgtcaac 3612961 atcatgctga acagcccgaa cagggtaatt gtgaggagcg gatgcgagcc gtatatcccc 3613021 aagctcaagc cgacggaaaa gctgtcaagg ctgacgccga tggcaaacag caataagccc 3613081 ggccctgccg gtgacatgaa tcgttcttct gactgtttaa aagaggccat aagcatttga 3613141 accccaagaa caaaaagcag cgccccaccg atataaaccg ctaacacgcc gaggagccct 3613201 gacagcatgt taccggccgc catccctgcg agaggcatga tgacgtgaaa gaggccgatg 3613261 atgaaaccaa tatagaatat ctgcttcttt ctaagtttga ccatgcccat tccaaggccg 3613321 acagaaaaag catccatccc taaagcaaac gccatgatgc ttaatgtaat cagttcgcct 3613381 ataaacaaat ccgacataca taaataaccc ccttggacac gccccgcttt tttagcctat 3613441 gcgtgtccaa aaagggttag aacatctgac tgctttcagc gaatcactct tcctccggcg 3613501 gctttcatca gcctgttcat aatagcaaga ccgacacctg tatccggaaa ggattccgct 3613561 ataatgaaat ccaccttatt ctcatcaaag ctgcgcaaag catcatacag ccctgccgca 3613621 acagtctcaa gctgagcccg tcttccgcag ctcttcacat aatcagcgga ataaacgccc 3613681 gctttttctt ctgtcgtcag gacaccgacc cgtcttccac cctgttgata ttcttgaatg 3613741 aggtgctgaa tgcgctctgg gctgccttcg caaatggcaa gaggcgctgt cggcgcataa 3613801 tgtgtatatt tcatccctgg agaaatcggc ttctcgtttt ggtcgctgag ccctttatcc 3613861 acatggatcg gcccgatcac cgcttcaatt tgttccttcg taatgccgcc aggacgcaag 3613921 agaacaggga tgtcgtccgc acatgaaagc acagttgatt cgaccccgat tccggtaggg 3613981 cctccatcca caataccggc tatgcggcca tccaagtcgt gagccacatg ctccgctttt 3614041 gtgggacttg gcttgcctga tagattggcg ctcggtgctg caatcggcag tcccgattcg 3614101 cgaatcaatg caagggcaag cggatgatcc ggcattctaa tggcaaccgt ttcaagacct 3614161 gccgttacac gaggtgaaag cgcatcaggt ttgcaaggca gaatgagcgt aagtgctccc 3614221 ggccaaaacc gtttcatcaa tgttttcgcc ttttccggcg ccgggcccgt taaatcctca 3614281 agctggctga tatccgcaat gtggacaatc aggggattat cgctcggccg ccctttcgcc 3614341 tcatatattt ttttgacggc atccgtattt tttgcgtttg cgcctaggcc atatactgtt 3614401 tctgtcggaa aggcaacgac ctcattttct cggagcaaag cggctgcttg tgcaatttgt 3614461 ggatcatttg tggataactc gtcagttaca tccacaaacc atcttttcgt tttcatttct 3614521 gaccaaactc cttattcaca acaataaaac gattgtttta cgcgtgtaat ccttttgaaa 3614581 gtataaaaga tgtcctgtaa taaaacaagc gttatccaca aattgtggac aacgctaata 3614641 aagaagtgga taagtatgtg tataaactgc acttatccag acgctttttt catcaaaacg 3614701 gctccttctg tttgccgcga ttcacagaag tgatcagaag aaaacagctc ctccggtaca 3614761 ctctcagctc tttcaaaacc catggccgtc agaaagtccg cagaggaatg ctgatttgct 3614821 actaggtaca cggttttgat ctgatgcttt tcgcacagca cctccatgct ttgaaaaagc 3614881 gtgacgatgt ggccttggtg aagcttgtcc gatatgacaa gtgatcgcag cagcccctgg 3614941 tcacagctta ttttttcaat accgaggcat ccggcaatgt ttttctcact gtcctccagc 3615001 ataagaaatt gagtgaagcc ttctttcacg ccttcatagc tggtttttgc ctgttttaaa 3615061 aatgcctcga gcacatctcc gtctttttcc cttgccaccc gcagttgata aaacatccgt 3615121 tcaccccgtt tttgcgttct ttcttccaat ctatgaggca aatctatttt tagaccagat 3615181 gattaggaaa aaaggtcgga aatccattcg actaaaaaga atttcacttc tgtgccgtct 3615241 tctttttctt cgttctcttc ttttttggct ttttccgctt tagcggttac gtcctcaagc 3615301 actttttcag tctgcttttt tgaggcttct ttatcttctt gttctttgac ggcttccccg 3615361 ttagaaaaat caagaaagca gaggggcggg aacagcacac accaccagtt ggcgccgtct 3615421 ccgtttccaa gcgtaatcaa aatcgcttca tactcaccag cgggatatac catgttgccg 3615481 taaagctttg tcggaaacga gattttgtca aaatcaacgg atatcgactg attcgctcct 3615541 tctttctcca ttgtttcctt tgcaattgct ttgatttcag gcagctttga acgaatcacg 3615601 cgacgcgctt cttcaataga agtaatatcc tttacccaag ttgtgatttc tttattcacc 3615661 gcgtctctta tatgacgttt taattgctgg tcttgatcac tatcgctgtt tgccagtatt 3615721 ctcaaacgaa tcgcctgatc aggtatgacc accggctgat tttccgattt ttgtgccgtc 3615781 tcttcttttg ccagccctac gagcgctccg gataataaaa gaaagatata tatacaaatg 3615841 attactgttt ttttcatcgg tccccaccgt tcctctccgt gctttgtttc tagccctatt 3615901 atggacaagg agagcctggg ataaacgtgc agggtgaaaa aaatctagca agctgttaat 3615961 cttatttatg gtacgatagt gttttaggag gtttaagatg aaatacaatt atacagtgct 3616021 gttatcagca ttcacgatgt ccgttcttta ttcagtaatt tatattcatt catttatcat 3616081 tgccgctctc atcacaatgg cattttattt tctgtttcct tatttgatct tcgcactgcc 3616141 gcttcaaatc atgatgaata aaaagccgaa acgtttcagc cctttgtatc tgctgtatta 3616201 ccttgccgct gcttttattg ccaacgcgat cattttcggc atgcttcagc cttcgggaca 3616261 atctctgttt caaaatacag ccttttatct tttcgctgta ttaacagctc ttatctattg 3616321 gatatgggat tctgttttac tgcaaaaaaa ggaagcctaa gaggcttcct tttttattaa 3616381 aacaaaatcg tcagtaaata acatagaatg gaaggtatcg ccgcaacaaa gaaagcggcc 3616441 gccattttca tgcgagatgt acggccttct ttggtttctg aatggtagtt tgcccgctga 3616501 tcgcttccgc ttacagccaa acccgatgta atgatcgcga gccccactaa aacgagagac 3616561 gcaacgccaa aaatcgcttc atatgaaaga gcctgcggaa aaatggtgcc aatcatgctc 3616621 tcaatcgcaa tgagcaggat tcctgctgtc agggcctttt tcatgtttac atcccctttg 3616681 ctggtgttaa acagcttgat ccattcactc gccagcaagc tgcttattta tttttatgaa 3616741 tcagagcgca tatggttctg tcttttccat taatatcttt cagcacttcc acttccgccc 3616801 ccttaaacgc cttgaggatc aggtctttga ccgccgctcc ctgtttccag ccgatttcaa 3616861 aaacgacaaa tactttatcc ttcataacaa gcggaatgtc ttccataaac cgcttataaa 3616921 atttcagccc gtctccgcca tcggtgagtg cgtgcagcgg ctcatgaaaa cggacaattt 3616981 ccgataaatc agccatttct tcctctgaaa tatatggcgg gtttgagaca atgatatccg 3617041 ctttttttcc cgccttaata aaaggctcaa gcagatcgcc ctgataaaag cgcacattcg 3617101 ctccgagttt ttctgcattg gcagaggcga cttgcagcgc ctctttcgaa atatcgaccg 3617161 ccgacacaga aaagctttgg ttttcaagcg caagcgtgac ggctattgcg ccgctccctg 3617221 taccaacgtc aacaacttcg agcttgccgt cttcagaaaa aacactccga tatttttcaa 3617281 gcaaatgaaa gacaacttct tcagtttccg gccgcgggat cagcacatca tcattcacca 3617341 taaattcccg tccataaaaa aactcttttc ctataatgta ttgaaccggc acgccctctt 3617401 tatgcatctc aacgtgacgc ttaaagcgat acagttcgtc ttcaccaatc ggttcctgta 3617461 agcttgcgag cagcttgctt ctctccattc cggtatcata aagcaatagg agctcggccg 3617521 cattttcttc tcttcccgct tcggttaaat aagaagaagc ccatttcagg gcttcgaata 3617581 tcgtcttcat cttaaccttc cgactgctga agcttgcttg cctgatcttc aacaatcagc 3617641 gcttcaacca cttcgtcaag ttttccttca agaatctgat caagcttttg aatcgtcaaa 3617701 ccgattctgt gatccgtcac acggttttgc gggaagttgt atgtgcggat acgttcagag 3617761 cggtcaccag atccgactgc tgatttccgt gtttgatcat attcagcctg ggcttcctgc 3617821 tgaaatttat catagattct ggcacggaga accttcattg ctttttcttt gttcttaatt 3617881 tgagattttt catcctggca tgatacaaca acacctgtcg gcaagtgagt cagacgaacc 3617941 gcagacattg ttgtgttaac gctttgtccg cccggtccgc ttgaagcaaa tgtatcgaca 3618001 cggatatcct tctcatggat gtcgacctct acctcttctg cctcaggaag acatgccact 3618061 gttgcagtgg atgtatggat gcgtccgcct gattctgttt ccggaacacg ctgtacgcgg 3618121 tgggcgccgt tttcatattt gagtttagaa tacgcgccgc ttcctgtaat cataaagatg 3618181 atctctttgt agccgcccgt tccggttaca ttcgcttcca tgacctctgt tttccagccc 3618241 tgaagctcag cataacggga atacattctg tacagattgc ccgcgaataa agcggcttcc 3618301 tcgcctcccg cagccccgcg gatctccatg ataacgtttt tgtcgtcatt aggatctttc 3618361 gggatcagga gcaccttcag ccgttctgac agtgtttccg tttccttctg aagttcagaa 3618421 atctcttcct tcaccatgtc gcgcatctca gcatccagct tctcttcaag catcgctttt 3618481 gcatcagcca gctgttctga cgcatctctg tattgtctat atacgtcaac tgtttcttgt 3618541 atatcagatt gctcttttga atattctctt agctttttcg gatcgttgac tacttctgga 3618601 tcgctcaaaa gctcatttaa tttctcgtat cgttcttcaa ttgattttaa acggtctaac 3618661 acggtcttca cctctgtttt cctgtgcgta acattctcat tatagtatag tgattaaccc 3618721 cagtcaaaag catttcaatc ccagctggaa aagctccctc tgctatactg gaattcgagg 3618781 agggatgatg ttgctgaaat ccatacatca tattgcaatc atatgttcag attacgaaaa 3618841 gtcgaaagct ttctacgtac ataagcttgg ttttcaggtg attcaagaaa cgtaccgcga 3618901 agagcgcggc tcctataagc ttgatttgtc gcttaacggc tcgtatgtca ttgagctgtt 3618961 ctcgtttccc gatccgcccg aacgacaaac ccggcctgaa gccgcaggcc tgcgccacct 3619021 cgcctttaca gtcggcagct tggataaagc tgttcaagag cttcatgaaa aaggaatcga 3619081 aacagagcca atcagaacag atccgctgac cggcaagcgt ttcaccttct tttttgatcc 3619141 tgaccagctt ccattagaac tgtatgaaca ataacagttt ttgaagaaaa aaaggagata 3619201 cccactttct ttgccgaatc ttttcttgtt ttgtctaacg ggaagggaac cgcattctat 3619261 ggtcgaatac ctagcttaaa aggaggtatg ggatcatgaa tacaaatatg gtagcaagtg 3619321 aactcggcgt ctccgcaaag acggtgcagc ggtgggtgaa gcagctgaat cttccggccg 3619381 aacgcaatga gctcggacac tattcgttca cggcagaaga cgtgaaggtt ctaaaatccg 3619441 ttcaaaaaca aatctctgaa ggcacggcga ttcaggatat tcatctgccg aaaagcgcta 3619501 aaaagcgcac aggcttcctt gtccaaaaaa caagtagcga cacagaacga agaatcgagc 3619561 agcttgaaca aaagctggac acccttttac agcaaaggca ggacgaaagc gaattgatgg 3619621 caaggatgtc ggaactggaa cgccagctga aacaaaaagc cgatgaaggt gtatcttacc 3619681 agctgcttca gcaccgcaga gaaatcgatg atattcttgc agatctgcaa tcactgacct 3619741 cacaaatgaa agaattcacc gctcattcga tccccgagac tgctgctgct tctgaaaaaa 3619801 ccaaaacaag aaaaaaaccg ctgctgtcac tgttcaaatt tcaaacctaa agcaaaaagc 3619861 tcccttaaag ggagcttttt ttgttacgca gtaagcgcga taatgattgg aagtgaaatc 3619921 aatgacagaa tcgcactgac cacaaacgca gttgcagttt cttcttcttg tttctcgaaa 3619981 cgagtcgcaa tcatggctgc aacggcagaa ccagggaatg caacaagaag gattgctttt 3620041 gttgtttggt cagctggaag tccgatagca agagcaatca ggaacattaa cgcaggctga 3620101 accgcaactt ttagtaacgc aataccgata gccggcatac tgagtttaat tttacgaata 3620161 ccaacggtaa caccaacagc gaagagagca acaccagatg ttgtgcttcc aagctgatca 3620221 agcattttaa cacccagctc aggaagagtg aaattgaaaa ccagcaccaa gatcatactg 3620281 attaacggag cagctgcaag cggctcacaa agaccatgca ggattgattt tcctgtcatc 3620341 ttccagaagc tgtcgccact ctcttcgttt ttcttagaag actcaccaac agtagcgata 3620401 atgatcgcga gcggatcaag aatcgcgtta accacgatac ctgtgaccgc gatcggaatc 3620461 gcaacttcat tcgctccgaa taagcttccc aataccggga tacccataaa tgcgaatgtc 3620521 ggctgtgcag agttcaaaga aaatacagat gagttcgtta aatcatactt gaatataaat 3620581 ctgcaaacca aaagaatgat gatatagaaa ccaacaatcc caataattaa agaaatcatt 3620641 aaaggtactt gtgataaaaa ttcacttctg gaagttgtca aaataccagc gataaagtga 3620701 gctggaagtg cgtatttcgt tactaacgta cttacccctt ttgccgactt ggcatcataa 3620761 cttccaaaat gtcctgcaaa ccaacccagc acgataacaa agaagatcgg cgccaggagg 3620821 attaagatat ctaagatgct caaaatattc tcctccaaat cctatgtccg tatactttag 3620881 ctttacaaaa agctttccct cggacagaaa aatttactcg ctaattattt cgcgatgact 3620941 tttttgtatt caggtgtcca cattgcatca agtaccgctt gtttcacatc ttcaggctga 3621001 cgatttgcca cgccgtcttt aattgctgct tcagcaacgg caatcgcaac ttggatagaa 3621061 acctcttgaa gcttatcaat gcttggaagc aatcctgctc caggtgtttc aagatcaacc 3621121 atttcagcaa tcgcatcagc agttgcagca aacatagcag gtgtaatgat acgcgcttca 3621181 gctacaattg aaccaagtcc aagaccaggg aacgcgaatg cgttgttaga ttgtccgatt 3621241 tcataagaaa caccgttgta ttctacattg tcaaatgggc ttcctgttgc aataagcact 3621301 tttccgtcag tccatttgaa cagatcttca ggaacagctt cagcaaggtg agtcgggtta 3621361 gacatcggca tgataaccgg acggtctacg tgagatgcca tttcttttac aatttcctct 3621421 gtgaatgcac ctgaaacccc tgaagtacca atcaagattg ttggtttcgc ttgacgaaca 3621481 acttcatcga atggaatttg acctttttca tcgcgcttcc agtctttcac ttcatccgca 3621541 ttgcgaaggt aaggtttttg gaaatcaagg atgccttcga tgtcttcagt cagcaagcct 3621601 ctgtaatcaa gtgtgtagaa acgtttgtta gcttcttctt cagataatcc ggctagcacc 3621661 attgtgtcac ggatttggtc agcaataccg ataccagcag aaccagcacc gaagataaca 3621721 acacgctgat ctttaataga agcgccggtt ttcttcatag cggcaagcac acctgcaagt 3621781 gtaatcgcgc cagtaccttg aatatcatca ttaaatgtca ggatttcatg attgtatttt 3621841 ttcatgatgt tgcgtgcatt tttgttgcca aggtcttccc agtgaagaag cgctttaggg 3621901 aagaatttca atgcagcttt tacataagcg tcaatgaaag cttcgtagcg ttcaccttga 3621961 acacgttcat gcttgttacc aatatataaa ggatcgttta gaagtttttc gttgttcgta 3622021 ccgacatcaa gcacaaccgg gataacacgg ctagggtcaa taccagctgc agcagtgtag 3622081 acagccaatt taccgattgc aatattaata ccgcctacac cccagtcacc gataccgaga 3622141 atgctttcgg agtcagtagc aacgataaga tcaatatcgc ctgctgtcgc atgaaggttt 3622201 tcaaacgctt tttcaatacc gtcaatgtta tcgattgaca agtagattcc ttgaggtctt 3622261 ctatattcat ggctgtattc ctgaatcgct tcaccaactg ttggcgtgta cacaacagga 3622321 agcatttcgc gaagatggtt tttcagcaat ttatagaaaa gaacttcgtt acggtttgca 3622381 agatcactta agtaaacatt ttgacgaagg cggtcaggct gcgcttggaa ttgctcgtac 3622441 gcgcgttgtg cttgttgatc aagagaaagt acagttggcg gcagaagccc ttctaagccg 3622501 agttcttgtc tttcttctag tgaaaaagca acgcctttat ttaaagtagg aatagataaa 3622561 acttcttttc ctctaagagt tgtttctaag tggccttctt tcgttttttt tatgttattc 3622621 aagcaaatct ccttctttct tgaaatagtt aaccaagtta agtaataacc catctaaaat 3622681 atgaccgatc atgatcttta tgcgactttg tgacaattat tcgaacaatg tctcaaaact 3622741 atttacatta cgtaagctat tgtatgcctg tcaaaatcaa aattcaagag aagaaaatta 3622801 cttaattttt taatatactt atttaaattt tttaattgaa tattatcaga atataaaaaa 3622861 aacaccggtg tttttagccg gtgcattcta tctttatacc catgttttgg actatttttt 3622921 agatttacct gggacttcgt gatgatgtct gcatcttgct tcatatgatt cagctgcacc 3622981 aaccaaaatg accggatcat cgtaagaagc aggtttgccg tcaatgaggc gctgtgttct 3623041 gctcgccggt gatccgcaaa cagaacagac ggcttgcagc tttgtcacac tttccgcaat 3623101 cgccatgata ttcgggacga caccgaacgg ctctccccta aaatccatat caaggcctgc 3623161 tgctatcaca cggtagcctt tatcggcaag agatgataaa acctcaacaa tttcctgatc 3623221 aaaaaactgc acttcatcaa ccgcaaccac atctgtactt tcactgatgt gatcccaaat 3623281 gtccgcagca gacgaaatgg catagctcgt catcgatgtt ccattatggg agacaacagc 3623341 agcttcgctg tatcggttat caattacagg cttaaatacc ctgacttcct gcttggcata 3623401 agttgctctc ttcactcttc tgatcagctc ttcagatttc cccgagaaca tgctgccgca 3623461 aatcagctca agccacccgc tttgtttcat tatgtacata ggcttcgctc ccctctctct 3623521 gccagctgtg ttttagacaa tataaaaaac aggcaagact gctgcttgcc tgttgagaaa 3623581 tctattatta cttaagaccg tattttttgt taaagcgatc aacacgacca tcagcagaag 3623641 cgaatttttg acggccagtg tagaatgggt ggcattcaga gcaaatctca acgcgtacct 3623701 cttcttttac tgagcctgtt tcaaattcat ttccgcaagc gcatttaact gttgcttttt 3623761 tgaaattagg atgaattcct gctttcattg tatccatctc cttccgccct gaatcccgtg 3623821 tggaaacaga gttattattt cggagcattg tccgaaacgc atatgagaaa attatatcag 3623881 tgatttactt cttttgcaaa tacaatttac cttcttgcag atgatagatt tgcctgtttc 3623941 cattcttgat tgagaatatc gaaaaattcc tggtttgttt tggttttttt catttttctc 3624001 atgaactttt ctgcgaaatc aggtgaatca gacatcgttt tgcggataga ccataaacga 3624061 tcaagatgct ctttaggcac aagcagctct tctttgcgcg ttcctgaacg gcggatatcg 3624121 atggcaggga agatgcggcg ctcggcaaga gagcggtcaa gatggagctc catgttgcct 3624181 gttcccttga attcttcata aatgacatca tccatacgtg aacctgtatc gaccagagcc 3624241 gtagcaagga tggttaagct gccgccctct tcgatatttc tcgcagcccc aaagaagcgt 3624301 ttcggacggt ggaacgccgc tgggtcaatc cccccggaaa gcgttcttcc acttggcgga 3624361 atcactaagt tgtaggcgcg ggcaagacgt gtgatgctgt ccatcaggat aatgacgtct 3624421 tttttgtgtt ccacgagacg catcgcacgt tcaagcacaa gctcggccac tttgatatgg 3624481 ttttccggca cttcatcaaa cgttgagctg acgacatccc cagctacaga gcgctcgata 3624541 tcggttactt cctcaggtct ttcgtcaatt aaaagcacga tcagctctgc ttcaggctgg 3624601 ttcgctgtaa tgctgttggc aatttccttc agcaacatcg tttttccggc tttcggcggc 3624661 gcaacaatca atccgcgctg cccaaatcca accggcgcca tcatgtccat aattcttgta 3624721 gacaagaagt tcggctttgt ttcaagcacc atttgacgat ccggataaag tggcgtaaga 3624781 gccgggaaat gcacacgctc ttttgcagat tcgggatcat ccccatttac tgcttcaacg 3624841 tgcaaaagtc catagtaacg ctcattttct tttggcgggc gaaccttgcc agatactttg 3624901 tctccgttcc gcaaatcgaa acggcggatt tgtgaagctg agatgtaaat gtcttctgag 3624961 cttggagagt agttgatcgg tctcaggaat ccgaaacctt cagactggat gatctcgaga 3625021 acgccttcca taaacagcag atcttcctgt tctgcattcg ctttcagaat ggcgaaaatg 3625081 agttcttttt ttgtcagttt gctgtaatag gagattttat aatgtcttgc aagttcataa 3625141 agctctttca atttcatatt ttccaaagag gaaatagata cgtctttcat aaaaacacca 3625201 cgcttttcat agtcaatatc ttactctgaa catgtcatct gctgcttttg cacaacatcc 3625261 gccaaagcac attctttttt taacataaag gaacttctat cggtaacact tccacccatg 3625321 atcggcgctt ttgttaaaag gattgtctta atgagttttg aaggaagcga ggacaaaaac 3625381 atgagaagat caatacttat atcgtctgta tgcggtagaa attgaaactt tcctagtgct 3625441 taaaagaagg tattacgcag taaaattcgc agcactcttt atttttacct tatttcaaaa 3625501 aattattcaa ctgaaataag gttttgacac ggaattgata gagttgacgc ttttctgcaa 3625561 aagttaaagc gggctcacac ccgctttttc tgtttgttat ggacggatta caagatttgg 3625621 tttctttttc aagctgtgtc tgccgtcaac gaaacgaaca gtgcccgatt ttgcacggat 3625681 aactaagctt tcagttgtac cgacagagcc tttgaattga actcctttta acagctcgcc 3625741 gtcagtaacc cctgtagctg caaaaatcgc gtcatcaccc ttcacaaggt cttccatgcg 3625801 aagcactttg cttaaatcaa ggcccatttt gtgacagcga gtgatttctt cttcgctttg 3625861 cggaagaagt ttaccaatga tttctccgcc gagtgctttt agcgcaacag cggaaagcac 3625921 accctcagga gcgccgcctg atccgaacag gatatcaacg cccgtgtggt cgaaagccgt 3625981 gttgatggcg cctgcgacat cgccgtcatt gatcaatttg attctggcgc cggcctcacg 3626041 aagctcggaa atgatttttg cgtgtctttc acggtttaaa attgtggcaa cgacgtcctc 3626101 aacgtccttg tttttcgctt ttgccaccgc tttaaggttg tcaatgacag gtgcttcgat 3626161 gtcaatgcag cccaccgctt ccggaccgac tgcgattttt tgcatataca tgtcaggagc 3626221 attcagaagc gtgccatggt ctgcgaccgc gataaccgtc agcgcgttcc agccgccgct 3626281 tgctaagatg tttgtgcctt caagagggtc aactgcgaca tcaacgcgag ggccgtaccc 3626341 gtttccgagt ttttccccga tatacagcat tggcgcttcg tccatttccc cttcaccgat 3626401 tacaacggtc cctttcatcg gcactgtatc aaaaacgtct ctcattgcac ttgttgccgc 3626461 ttcatcagcc tcatcttttt ttccccggcc catccatctt gctgatgcca atgccgcagc 3626521 ttctgtcaca cgtaccaatt ccattgataa acttctttcc atttcaacac gatctcctct 3626581 cacaagaaac cattatgaat tttgaagctg ttctatttct tcgtcagtca ttctttcacg 3626641 ccaaattgtc gctccaagcc cctcaagctt cttctcaagg ctgctgtatc ctcggtcaat 3626701 atgctccagt cccgtaattt ccgtgacgcc atcagccatc agtccggcta ccaccaagca 3626761 ggctccggca cgcagatcac tcgccttcac ttttgcgcct tgaagctcga caggacctgt 3626821 gatgatggca gatctgcctt ctactttcat attggcaccc attcgtctca gctcatcaat 3626881 gtgcttgaat cttgccgagt agatggtgtc tgtgacgaca ctcgtccctt tcgcccttgt 3626941 caggagcgcc gtcatcggct gctgtaaatc agtcggaaac cccgggtata cgagggtttt 3627001 gacgtcaacc ggctttaagt tcttctgccc gccgacaatg aggagctggt cgtcgcttgt 3627061 ttcgatatga tagcccattt ctctcagctt tgccgttaac gactcaagat gagtagggat 3627121 gacgttatcg ataatgactt ccttgcccat tgcagcccct gcaatcataa atgtcccggc 3627181 ttcaattctg tccggaatga tcgtatgctt gcagccgtgc agttccttca cgccgtcgat 3627241 tcgaatcaca ttggtgcccg cacctttgat tttggcgccc atgctggtaa gcaatgtcgc 3627301 gacgtcaatg atctcaggct ccttggcagc gttttcgatg atcgttttcc cttctgccaa 3627361 aacagcggcg agcataatgt taatcgttgc cccaacgctt acgacatcta aataaatccg 3627421 tgcgcctctc agcctttcag ctcgcaaata aatggcgcct tgttcattgg ttacttcagc 3627481 tccgagtgct tcaaagcctt tgatatgctg atcaatcgga cggggcccta agtgacagcc 3627541 gccaggcaat ccaatgaccg cctgcttgaa gcggccgagc atcgccccca ttaaataata 3627601 tgacgcgcga agctttttta ctttcccgtt aggaagcggc atgctgatca tcgacgtagg 3627661 gtcaacaacc atttccccat tctcaaaatg cacgttgccg ccgatttcct ttaacaggtc 3627721 acgcagcgtt tcaatatctg aaatctctgg aagcccttca attgtcacct cggaatttgc 3627781 caaaatggtt gcaggtatta acgcaacagc gctgttttta gcgccgctga tatgtactgt 3627841 accgtttaac gagtcaccgc cggcaatatt caacttttcc atgatagtct ccttccataa 3627901 gaagatagct gcggagctaa ataaaatgtc attttattct gtctctgcaa ataaagctca 3627961 tgtccaaaat ctagccaatt cgaagagaaa gaatacaaca cattgtaaaa tatcaggaag 3628021 aaaatagcga agctttgggg ggtacaggtt tcaaaagatg cacagagacc cgccggctcg 3628081 agagacatcg tcgtcatccg gcaaaagcag tacgcatacc cttcattccg atatcagctt 3628141 ctgcagccca atgattcctt ctctgtaaag cggcgtcagc atctgaagat ccgctgtatc 3628201 aggtcggtga aatacaaagg ccgcggcaaa caggcataaa gctgtttgcc gcccctttca 3628261 ttatttgttc cagtctgcca ggaattgttc gattcctttg tctgttaacg ggtgtttagt 3628321 gagcgcatga atgactttca gcggcattgt gccgatatga gcccctctaa gagcagcttc 3628381 tgtcacgtgc tgcggatggc ggattgacgc tgcaatgatt tgcgtgtcaa ggccgtgaat 3628441 gtcaaaaatc tgtttaactt ctgaaatcag gtcaagcccg ttgtggccga tgtcatctaa 3628501 acgtcccagg aatggagata catatgttgc ccccgctctg gcagcaagaa gcgcctggtt 3628561 ggcattgaag atcaatgtaa cgtttgtttt gatgcctaag tcagtaagtg ctcttaccgc 3628621 ttttaaaccg tcagacgtca ttgggatttt caccgtaatg ttcggagcga tcttcgccag 3628681 ttcttttcct tcctcgatca tttcctcagc tttcaaagaa ataacctctg cgcttacaga 3628741 ccctttcacg acgtctgtga tctcgcgaag acggtcgtgg aatgatacgt tagcttcctt 3628801 tgctactaaa ctaggattcg tcgttacacc ggcgagaatt cctaattcat tcgcttctct 3628861 aatttcatcg atattggctg tatcaacaaa gaataacatt ttcaaaaagc ctccctgatt 3628921 aagaaatttt ctgaactgcg aatatgattg cgctttctaa agatagacgg aaaaccgcct 3628981 gtcaagctgt caggcggcta taaaaagttc caattgaatt aagcttggtt tgaagaacca 3629041 aattcacgca ttttaccgat aactgtttct ttgatcgctt cacgagctgg tccaaggtat 3629101 ttacgtggat cgtactcgtc aggcttagct gccaatgttt cgcgaacagc ttttgcagaa 3629161 gaaatttggt tttcagtatt cacgttgatt ttagctgtac caagtgaaat tgattttttg 3629221 atgtcagcag tcggaattcc agtaccgccg tgaagaacta gcggaaggcc agttgatttt 3629281 ccgatctctt ccatttcttt gaagccaagg tttggctcac ctttgtaagg gccgtgaaca 3629341 gaacctaatg caggtgcaag gcagtcgatg ccagtgcgct caacaagctc ttggcactct 3629401 ttaggatcag cgtagattac gccttcagcg ataacgtcat cttcttgtcc gcctactgtt 3629461 ccaagctcag cttctacaga tactccgtgg aaatgagcaa gctcaacaac tttagcagtt 3629521 gttgctacgt tttcttcaaa tggatggtga gaagcgtcga tcattacaga tgtgaaacct 3629581 gcatgaatcg ctttcgcaca agattcaaag cttgaaccgt ggtctaagtg aatcgcaaca 3629641 ggaactgtca ctttgtactc ttccataagt gcttttacca tagcaacgac tgttttgaag 3629701 ccgcccatgt agcgtcccgc accttcggaa acaccaagga tcactggaga tttttcttct 3629761 tcagctgctt gtaaaatcgc ttgagtaaac tcaaggttgt ttaagttaaa ttgtcctaca 3629821 gcgtaccctt tttctttagc tgtattcaac atttccgtca tagaaactaa aggcatgtcg 3629881 aatgtcctcc ttatgtagcc tgattgtctt ctagcgaaaa aagctttcca ccctagcatg 3629941 acccatatat tgctgtcata tgtaaatact cagatcgctt tttctccata actaggatac 3630001 caacttttcg acaaatcggc aacataatga catgattcat ttgtttcttc tttttgtcag 3630061 ttagacttca ggggcagata ttttttgacg gcgtctctga tttcgtcgat gtcaaacggc 3630121 ttggcaaagt gcgtcagagc gcccaattcc ttcgattcct ggatcatgtc gagctctccg 3630181 tatgccgtca tgataatgac ccggatgttt tcgtcaatga ccttcatccg ttttaagatt 3630241 tcgattccgt ccatgccggg aattttcatg tccaacagca caaggtcggg ccgttctttt 3630301 gtcacaatgt caagcgcctg caggccgttc gcagcctgaa acgtctggta gccttcttta 3630361 ttgaacactt catttagcaa aatacgaatg ccgtattgat catcaacgat taaaattttt 3630421 tcattcatca ttttacaccc caatattatg attttcgtca aaagtaagca gtattgtatg 3630481 tattctgttt gattttccta tttcctttaa ttataatagt ctactttacg acattttctg 3630541 agcattttct cttttgttgt atactgatat tgtacgttat aaaggaggat tcacttatgt 3630601 tgaaaatatt cacgacgcag ttaacaggta ttttttcccg cattcaggat aaggaatctg 3630661 acgcgattga agatggggcg cggctgcttg ctcaagcggt gatcagcggg cattccattt 3630721 atttatacgg agcgaatgag cttcagggcg tcttttatga ggccaccgaa agcaaagaac 3630781 ccttcccatc tgtcaaagcc tttccagaaa acgctgagga agtgacagaa agcgacaggg 3630841 tgctgatgtt ttgctcaggg acgggcacag ccgaagaaca ggagctcgca aaagagcttt 3630901 atgaaaaagg tgcgggagtc gtatgcgtat cgcccgcagc caaagacagt gcgggaatag 3630961 aacagtattg tgatgtgcat attgattcta aattaaaaat gccgcttgtt cccgatgaag 3631021 acggcacccg ttacgggttt ccctctttaa tgacagcact gtatgtctat cacgctttat 3631081 cgtttacact aaaagaaatt ctgcaagagt atgcataata tcttattgta catgctggaa 3631141 cttgccggaa acaaataaaa aagacttgcc cgcttttgac aaacggcaag tcttttttat 3631201 tacttctgat ttgcagcttc gacagacgct ccgataaagc ctttgaatag aggctgaggt 3631261 cttgtcggtc ttgacttgaa ctctgggtgg aactgagaag ccacgaacca agggtggtct 3631321 ttcagctcga tgatttcaac aaggcgtcca tcagggcttg tgcctgagaa tacgaagcct 3631381 tgctcttcca tttgctgtct gaattcattg ttaaactcat agcggtggcg gtggcgctcg 3631441 tacaccactt catcctgata cacttcaaag gctttcgtgc cttcttcaag cttacaaggg 3631501 taaaggccga gacgaagcgt tcccccaaga tcctcaacat ccttttgttc aggaagaaga 3631561 tcaatgatcg ggtattgagt tgacggatca atttccgctg agtgagcgcc ttttaagccc 3631621 aatacgtttc gtgcgtattc aatagacgcc acctgcatgc ccaagcaaat gcccaagaac 3631681 ggaatgttgt tttcgcgcgc gtattttgtc gcgacgattt tcccttcaac accgcggtct 3631741 ccgaatccgc ccggcacaat gatgccgtct gttccgcttg tgagttctgc gatattgttt 3631801 tctgtcactt cttccgcgtt gatccacttc acttttacat ctgtgtcaaa cgcatagccc 3631861 gcatggcgga gagactcgac aacagaaatg tatgcgtcag gaagctcaac gtatttgccg 3631921 acaaggccga ttgtaatcgt ttgagacagg ttgctgactt tgttaacaag ctctttccac 3631981 tcggacattt ccgcttcttt gcatgccaat ttcatgtgct cgcaaacaag cttatcaagc 3632041 ccttgttttt gaagctccag cggaatggag taaaggttgt ccgcatcttc acattcaata 3632101 accgcttttg tatcgatgtc gcagaaaagc gcgattttat ctttcatatc ttgagaaatc 3632161 ggcatttctg tacgaacgac gatgatgttt ggctgaatgc ccaagctgcg caattctttt 3632221 acgctgtgct gtgtcggttt tgtttttaat tcgccagcag ctttaatgta aggcacgagc 3632281 gtacagtgga tgtacattac gttttcacgg ccgatgtcgc tcttcatttg gcggatcgct 3632341 tcaaggaatg gcagtgattc gatgtctccg acagtaccgc cgatttctgt aatgacaaca 3632401 tctgcgtttg tctctttccc tgcgcggtaa acacggtctt tcaattcgtt tgtgatgtgc 3632461 ggaatgacct gtacggttcc tccaaggtaa tctccgcggc gttctttttt aagaactgtt 3632521 gaatagattt tacctgttgt cacgttgctg aatttattca ggttaatgtc gataaaacgc 3632581 tcatagtgac caaggtccaa gtctgtttca gcgccgtcat ccgttacgaa tacttcaccg 3632641 tgctggtacg ggctcattgt tcccgggtca acgttgatgt atggatcgaa tttttgaatc 3632701 gtcacgttca gtccgcggtt tttcagcaaa cgccctaatg aagctgctac aatacccttt 3632761 ccaagtgagg atacaactcc cccggttaca aaaatatatt tcgtcatttc gtttgctcct 3632821 ctcttcgctc ttagctacat ttttaaaatg tactatttta taaaaaatca tttagccttt 3632881 taaatgattt ataagaaaaa tgaggggtga aaataagaaa gctccctttc aatttcttga 3632941 aagggagcat aacgtactat gttctctctt cgtttttgaa gagcccaaaa tacatactac 3633001 atagttcgac tatgaaagtc aagatcgttt tgaagatgaa atctgatact atttaatttc 3633061 ctcttcttca tcatcatagt cttcatcatc ttcatcaata atatcttctt cgatctcaag 3633121 atcatcgtcg tcttcatcaa gatcttcttc gtcaaaatcg tcggcttcaa gatcgagttc 3633181 ttcctcaact tcatccaaat caaggtcgtc ttcgtcgatc tcttcaaact cgtcaagatc 3633241 aagatcttct tcgactgctt tcttcgcttt tttctttttc gccttgactg tcggctgagt 3633301 ttcttcatca agctgatcat aaggatacca gctgcgaagc ccccacgtct ggtcagaaag 3633361 cgccaggaag cggccgtcaa tgtttaaatc tgtataaaat tgagcaatgc ggtctccaag 3633421 ctcttctttt ttcacgccga gcaaagatgc gatttcattt aaaagctcct gaaaaggaac 3633481 tggtttttta tgttcttcaa ataattcgtg agcgatttca actaaagcca tttcctttag 3633541 ctcttcctgt gaatattgtt tgatacccaa ggtcggacac tccctttcta ttacttatat 3633601 gtatctgttt tatcaataat gaaagcgatt ttgtatcgtt cttatacaaa ccatacctct 3633661 cattataaac aaaataaaac agaatatgct acccttaaca gcgttaattt aaataatttt 3633721 acaagagtga tccgactgag agatgttttc cgttaatccg cgagcattct ggagatgacc 3633781 agtctttgaa tttcttgagt gccttcatag atttgcgtga tttttgcatc acgcatatag 3633841 cgttctaccg gataatcttt tgtatagccg tagccgccga aaatctgcac ggcttcggtc 3633901 gttaccttca tcgccgtatc cccagccatc agtttggaca tggcggaagc ttttccatat 3633961 ggaaggcccg atgattctaa ccatgcagcc tgataggtca gtagccttga agcttctatc 3634021 attgtcgcca tatccgcgag tttaaaagcg atgccctgct gctcggcgat cgattttccg 3634081 aattgctttc gctcttttgc atattgaagc gccgcatcaa gcgctccttg ggcgatgcct 3634141 acagcttgtg cagctatgcc gtttctgcct ccgtcaagcg tcttcatcgc gattttgaag 3634201 ccttctcctt cttctccgag acgctttgat gcgggcacta cacaatcttc gaacatgatt 3634261 tccgttgtcg gtgaagaacg gatgcccagc ttcttttctt tcttgcctgt aaaaaatcct 3634321 tcaaaatcct tttctactat aaaagcggta acgccttttt tctttttctc gggatcggtg 3634381 acggcaaaaa caatgtaaat atcagcaacg ccgccgtttg tgataaacac tttggaacca 3634441 tttaacacat agtcatcgcc gattcgttca gcagttgttt tcatgctgcc ggcgtcagag 3634501 ccagaccctg cttcggtcaa agcgaatgcg ccgattttct ctccgagagc cagctgtgtt 3634561 aagtactctg tcttctgttc ctctgtccca aaggcaaaca gcggccagct gcaaagagag 3634621 atatgggcgg aaagcgtcac accggtggag gcgcacactt ttgacagctc ttccaccgcg 3634681 atgacgtagg ctaaatagtc acttccaatt ccgccgtaat cttcaggcca tggaattccc 3634741 gtcaggccca gatttgccat ttcccgaaac agctcgcgat cgaagcgttc ttgttcgtcc 3634801 cgttcagccg ctgtcggggc cacctcatgc ttcgcaaaat cgcgcaccaa ttttcgtatc 3634861 atctcatgtt cttctgataa tgaaaaattc attgcttctc ccccattttc agatcagcgc 3634921 ctaaaacgga ttgagccaga agctcgacga cgtcgtacgt tttgacttgg tcttcggctt 3634981 ccttcgcctt tgtgccgtcc ccaagcatcg tgagacaata cggacagcca gaactgatca 3635041 ccgatgggtt gactgcgagc gcttgctctg tcctggcgac gttaatcctg ttgcctgttt 3635101 cttcctccat ccacattaat cccccgccgg ctccgcagca catgccggtt tcccggcttc 3635161 tctccatttc aacaagctgc acgcccggaa tggctttcaa aatctctctc ggcggatcat 3635221 agacttcatt gtaccggccc aaatagcacg aatcatggaa ggtaatcgtc tcatgaagcg 3635281 ggtgctgcgg tcttaatttt ccgtttttca caagctcggc cagcacttct gtatgatgat 3635341 aaacctcgcc ttcaaatccg aaatccggat attcgttttt aaataaattg tatgcatggg 3635401 gatcgatcgt aacgattttt ttgacatcat ttttttcaaa ttcagaaata ttcttctcag 3635461 ccagctcttg gaacaaaaat tcatttccga ggcggcgcgg cgtgtctcct gaattttttt 3635521 ctttattgcc gagaatcgcg aaggacacgc ccgcgtgatt gagcagcttg gcaaaggaaa 3635581 ttgcgatttt ctggcttctg ttgtcgtaag accccatgga gcctacccag aaaaggtact 3635641 caaattcttt tccttctttt ttcatttctt ttacagtcgg aatctcagca tccggcgcct 3635701 cgtcacgcca attttcacgt tccttgcggt tgagtcccca cggattccct tgccgctcaa 3635761 tacttgtcat tgcgcgctgg gcgtcactgt ccatttttcc ttctgtcagt acgaggtagc 3635821 ggcggaggtc gatgatttta tccacgtgct cattcatgac cgggcattga tcctcacagt 3635881 tccggcaagt ggtgcatgcc caaatttctt cctctgtgat gacgtcgccg atcaagcttg 3635941 gattgtaatc aagcgccgct gcggcttcct gcgatccgct gcccgctgac gccgcagcca 3636001 gctgattgcc tctcgtatgc cgaaacgctg ctgcgggcac ccatggggag cgcgaggtga 3636061 cggcagcgcc tttttccgtg agatggtctc tgagacgcaa aatcaagtcc atcggagaaa 3636121 gcatttttcc ggtgcctgtt gcaggacaca tattggtaca gcggccgcac tcgacacacg 3636181 cgtatagatc aagcagctga gactgtctga aatcctcaat ttttcccgct ccgtagcttt 3636241 ctttcgtttc gtcggtaaaa tcaatttttt caagttttcc ggcagattcc attcgattga 3636301 aaaagacgtt tgccgggccg gcgattaaat gggcatgctt tgactgaggc acgtacacta 3636361 aaaagctaag caagaatagg agatggatcc accatgcgat atagaaaatc accgccgcgc 3636421 ctgttttccc gacaccgcta agcataaacg caatacctga ggcaattggc tcgctccaag 3636481 aaagcccatg ctcatgccaa atcagattca tcccgttccc aagcagaacg gtcagcatta 3636541 atcctccgat aaaaatgaga acgagtccgg ctttgaaacc gcgtttcagc ctcacgagct 3636601 tttcgatata acgtctgtag aatgcccacc caacagcaat taaaatgaga aacgtaacaa 3636661 tttcctgaaa aaaggtgaag gcgggataga ccgggccaag cgacagattc cggccgggag 3636721 ccagtccttt gatgataaag tcaattgctc cgaactgaac caatataaat ccgtagaaaa 3636781 acatgacgtg aatgattccg cttttcttgt ccttgagcag ttttttctgt ccgaatacat 3636841 tcacccatat ggcgtgaagc cgttccttga accgttgatc aaattgttct ttctggccga 3636901 gcttgatgta ggccagtctc gttttgacca agtaaacaaa caaatagaca gcgtaagcgg 3636961 ttacaatcag aaataataat gcatttgcga tgagaaagcc gctcattcca attccccctt 3637021 tttactgata aagaccgcga tcccctaccc ccgaatctgt ataagattat ctttatgata 3637081 aataatgaat gagtgttcag tcaataatta aattcctgct gttcgggcac actaccttta 3637141 ctacggaaag gagtgccggt atgaaggtat ttatcgtgat tatgatcatt gtcgttattt 3637201 tctttgcctt gattctgctt gatatcttca tgggccgtgc cggatacaga aaaaaggcgt 3637261 acgagcctgt tttttcaaaa aagaagagtg acatcgaatt gatccactgc ggcgctgatc 3637321 tcgttgagcg gatgatgaat gatattcgcc aggccgcctc ttctgttcac atgatgtttt 3637381 ttattatgaa aaatgatgag gtcagccaca atatgtatac cttgctgaaa acaaaagccc 3637441 aagctggcgt atccgtttat ttgcttctgg attgggcggg ctgccgggca attaaaaaaa 3637501 cggcgcttca gacgatgaaa aatgccggcg tccatgtcca tgtgatgaat cgtccccgtt 3637561 ttcctttttt cttttttcac atgcaaaaac ggaatcaccg gaagattacg gtgatagacg 3637621 gaaaaatcgg ttatatcggc gggtttaata tcgccgaaga atatcttgga aagaaggcga 3637681 agttcggcaa ttgggaggat tatcatctgc gcatgatcgg agaaggcgta catgatcttc 3637741 aaacgctttt tgcttctgat ctaaaacgaa ataccggaat cgaactgggt tcggatgttt 3637801 ggccaaagct tcagcaaggg actatttctc acaagatcta tgcgaccgac ggttattccc 3637861 ttgaaaacat atacttggcc aacattgccc aagcgaagaa tcgccttacg gtttgcacgc 3637921 cttattacat tccatcaaaa ccgcttcaag aggcccttat taacgcaaga aaaaacggcg 3637981 tatccgtgag aatcattgta ccgatgaaat cagaccatcc gctggtacga gaagcggctt 3638041 ttacgtatta ttcggagctc ttggatgccg gctgtcttat ttatcgttat tatcaagggt 3638101 tttatcatgt aaaagccctc atcatagacg accatctcag cattatcgga acagccaact 3638161 tcgataaacg gagcctgttc ttaaatgaag aggtgaatgt tgaaattgat gacgaagcgt 3638221 ttacaagtga agtctatgcc acaattgagg aggatatgaa aaagtcggag ctgctgacga 3638281 tggaggattt cagcaagcgc acattcaggc agcgcccggc ggaatggctc ggcagggcat 3638341 tatcttattt cttataaagg agagttccta tgattttcag attcgggttc gtttcaaatg 3638401 cgatgagcct ttgggatgcg tctcccgcta aaacattgac attcgcgcgt tattcaaagc 3638461 tttcaaagac tgaaagaaaa gaagcgcttc tgactgtgac aaaagccaat ttgcgcaata 3638521 cgatgagaac ccttcactat atcatcggcc acggcattcc tttgtaccgt ttttccagtt 3638581 cgattgtgcc gctggctacg catcccgacg tgatgtggga ttttgtaaca ccgtttcaaa 3638641 aagagtttcg ggagattgga gagcttgtta aaacccatca actgcgaaca agctttcatc 3638701 caaatcaatt cactctgttt acgagcccga aggaatccgt cacaaaaaat gcggtaacag 3638761 atatggcgta tcactaccgc atgcttgagg ccatgggcat tgctgatcgc tccgttatca 3638821 acattcatat tggcggcgct tacggaaata aagacaccgc cactgcacaa tttcatcaaa 3638881 atataaaaca gctgccgcag gagatcaaag agcggatgac acttgaaaat gatgataaaa 3638941 catatacaac ggaagaaacg cttcaggtct gtgagcagga ggatgttccg tttgtctttg 3639001 actttcatca tttttacgcc aatccagacg atcacgccga cctgaatgta gcactgcccc 3639061 gcatgatcaa aacgtgggag cggatcggcc ttcagccaaa ggttcacttg tcttccccaa 3639121 aatcggagca agcgatacgc agccacgccg attatgttga cgccaacttt ttgctgccac 3639181 tgttggaacg ctttaggcaa tggggaacta atattgattt catgattgaa gcaaagcaga 3639241 aagacaaggc gcttctccgc ttgatggatg aattaagctc catccgcggt gtcaaacgca 3639301 tcgggggcgg tgcgctgcaa tggaagtcat aaatgtgcaa aaataggttt acgacttgtc 3639361 agctttggga acttaggcta tataagacaa caatcgatgg aggagaaaga tcatgaaaaa 3639421 tatcaagtct ctgaaagtag ccgcacaggc ctttacttta agaaatttga ttcatcttta 3639481 taaaatgtgc cattccggaa gccacgaggt ttatatttat tcaaagaaaa cgatgtgcaa 3639541 aatcaaaagc ttaattgagc ttgaaacgtt ccgcatggct cataatgaaa aggaatatct 3639601 gatcgtagtt gaaggaacaa aagcatcaca gctcattgaa aaattccaaa atctcatcga 3639661 gcctgctgag agagaagcgc tctaacttac atacaaaaaa ggatagacat ctgtctatcc 3639721 tttttcttat gctcttacat aatggagctg aaccgcttgt ccaaattgtt ttgtcccttt 3639781 taaccgcagt tttgtttcat ttgttagttc gtgaaacagc gggatgccgc ttcctaaaac 3639841 gacgggaata acagtgatga tgaattcgtc gatggcatct tctttcataa agtcattcac 3639901 aagctctgcc ccgccagcta tccagatgtt tgagcctttt tcctgtttca aacgggcagt 3639961 gaaggctctg gctccctcat tgataaacgt cacatgttca tcttgataac tgtcgggcga 3640021 tcctgtaaaa acatagcagg ttttatcctg atacgggaaa accggtgtta gcactttaac 3640081 gtgctcatat gtgctccgcc ctaaaatgac tgtatcaaca gtctgataaa aatcactgta 3640141 gccgttgtca ccttcacctt caaattcatc cagccaatcg atgcttccat cttcttttgc 3640201 gatcatcccg tccaatgaaa cagcaatgta cagcacagtt tttctttcca tgttctcctc 3640261 ctatcgatgc accatttgcc cgaattgcgc ttgatgcagc ctgctgtata ggcctccggc 3640321 ttcgatcagg tcttgatgac ggccttgttc ttcaataccg ttgtttgtga cgactacaat 3640381 tctgtccgcg tctttgattg ttgccagcct gtgggcgatg acaagcgtcg tgcgcccctc 3640441 agacaactct tgaagcgcct tttggatcgc cgcttccgtc tctgtatcaa gggctgaggt 3640501 ggcttcgtcg agaatcaaga tcgacggatt tttcaagaac atccttgcaa ttgacagacg 3640561 ctgtttttgc ccgccggaaa gcttcacgcc gcgttcgcca atcatagtat ccaacccatc 3640621 gggcatgtta tggacgagct cttccagatg cgcctgcttc acagcttgcc aaatgtcttc 3640681 ttctgatgcg cctagtcggc cgtaggcgat attttctcta agcgtgcccg agaataagaa 3640741 aacgtcctgc tgcacgacgc caatctgccc gcgcaacgaa gaaagcgtca tgtcttttat 3640801 actgatgccg tcaatcgtaa tgtcgccctc cgatgcttca taaaaacgcg gaagcagact 3640861 gcaaagcgtt gatttcccag cacctgacgg accgacgaac gccaccgttt cccccgcttg 3640921 aatggatagg ttgatgtcat tgaggacatt gtgatggtca tcatagccaa acgaaacatg 3640981 tttatagcgg atattgccct tcaggccgga aacatctttc gaatcaggtg agtcctgaat 3641041 atccggctct gtctccatga gctccatata gcttttgaaa cccgcgatcc ccctcggata 3641101 catttcgata atggcattaa ttttgtcaat aggcctgaac agcacattcg tcaagagtac 3641161 aaacgccaca aattccccgt acgataagga gccgcgaatg acaaaccacg tcccgcacaa 3641221 aaggacaaac agcgtgacaa accgggtcag catatagctg attgaaccgt ttttcgccat 3641281 gattttgtag gaagaaagct ttgtgacacg aaaacgctgg ttgttgacgg cgaagcgttc 3641341 tttttcaaat gcttcatttc cgaacgcctg cacaagccgg atgccgccga tgttattttc 3641401 tacacgcgcg ctgaagtctc cgatatcctt gttcagcgtg gtaaatgctt tggtcatttt 3641461 tttgttgaaa taaagcgcta gccaaatgac gatcggcata atgataaacg ttaataaagc 3641521 aagctgccag ttaataaaca gcatcactcc gaacgccccg agaatggtca tgaccgcaat 3641581 gaataagtct tccggtccgt gatgggcgac ttcaccgata tacattaaat cgttcgtgag 3641641 cttcgacatc agcgttcccg tcttgttgtt gtcgtaaaat ttgaacgaga gcttttgcaa 3641701 atggtcaaaa agcgactttc tcatatcagt ctcaatattg ataccaagca tgtgtcccca 3641761 gtaggtcacg atatactgaa gagccgagct gagcgcgtac accgcaaata acccgattga 3641821 ggtcgcgatg atcagtcccc agtccctgcc cggcagcaag gtatcaataa aataattgac 3641881 gatcaaagga aaactcagct ccattaaacc tcccgcgatc gctgagaaaa agtcgagaaa 3641941 gaacaacgtt ttatatggtt tataatatga aaaaaattgc cgcagcaccc tatcttcccc 3642001 caatgtataa ataactgata atatttctca attatactat acacgggctg ttttgtaaga 3642061 tcagatttct tttttcttac agaacacctg aaaacaggcg ggcaaacgac tcttttgtcc 3642121 ggtcagccac acctctttta taaaagccga cagggctgag cttttcactt tcctgcatat 3642181 cctcttcaaa atgggcctca agggttcgga tcgcttcggc atccgtgaag aacacattca 3642241 cttcaaagtt gagctgaaag ctgcgcatgt ccatattcgc ggtaccgacg gaggcgagat 3642301 cgccatcaat gatcatgact ttttgatgca tgaagccttt ttggtaggag tacacttcaa 3642361 tgccctcaag gagcagctcc gggaaatagg acctcgacgc gtattgggtc aaaaagctgt 3642421 cgttcttctc cggcaccata acccttacct ctaccccctt tgtcgccgct gcttttagcg 3642481 ccgtgcgaat ggattcattg gggacaaaat agggcgtggc gatccatatt gatttctgcg 3642541 ctgaagaaat catttcataa taaaggtcgc tcatgctttc cttcatgtca gggcctgtcg 3642601 cgacaatttg ataaatgcct cctccttcca cgggaaccgg ggtattgtac tcctcttgat 3642661 caattagcac ttcattggag acatattccc aatccagcat aaagatagcg tggagcgttt 3642721 gcacaatttc cccctcaagc cgcaggtgtg tatctctcca aaatccgatg tacggatctc 3642781 tgctgatata ttccttcccg acatttaatc cacccacaaa accggttttc ccatcgatga 3642841 tcacgatttt ccggtgattt ctgaaattca gcttctggtt gaaaaacccg tatttcagcg 3642901 gagaaaacgg gacgatgtcc acccccgctt gtttcattct cataatatct cttcttgcca 3642961 gcttcatgct tcctgccgca tcgtataaaa acctcacctc gacaccctgg cgcgctttct 3643021 ccatcataat atccatcatg ccgcgtccga gcatgtctga tttaaacatg tagtattcaa 3643081 tatgtatgta agattccgct tttctcattg ctttgaaaat gtccgggaag gtttcttcgc 3643141 cgtttttcag cactttgatg ttgcttttcg tattgatatt catatgggca gccctgatgg 3643201 aatatgtaaa gaacctctct tgattgtcct tcagccctgt cacttcgggc gtttcctcct 3643261 tgtcaaacag cttcctgagc ttttccctgt tgtacattcg ttttgtctta aacagctttc 3643321 cctttacata aagctgtccc gaaaacagat aaaacacgta gccgacgatt ggaaaaaaga 3643381 caagaatatg gatccatagc agcgtgtgct gcgaggtgcg gttttcaaga attaatgaat 3643441 agatgctgaa caaaataatg cttatatagc aaagcaatcc tccgtaaaac tcaagtctgg 3643501 aaaccggaaa aaaccaaatg acatatgccc cgatgagcat catatataaa aagaaaaatt 3643561 ccagtctcct tttcagcatc ctgattctct ccaatctgat tcaattacct ctgtattacc 3643621 tcttttttct aatcgataaa ccttgtaagt aaaaaacctc tccgccaaag gaggagaggt 3643681 ttagagaaaa ctaactgtca cggaattcat ccgcatcgtt tctgcagaaa taaagcaaga 3643741 ctattggcaa cgccgagtga caacatgagc ggcaagctga acccgctcag cactccggca 3643801 agcgccgaaa agaaggcggc gctgtgactg caaatacggt ggatagagta aatttgatac 3643861 ccattctgat gagagaaaat atataaaacg ggaaattgat cagaaagata taaggagtta 3643921 gtcaggctga atcataatct ggctgttccg ccggtttaaa atgagtaaaa tccttgatgt 3643981 tatttccata tacaaacata acaggattcc cggcagccca gccattacct tggcagaaaa 3644041 aaccccctct tgcaaggggg attttcacga gcgtttccga tatacaacgt agctgcgggt 3644101 cagatacttg agcggcagac tgaacacatg aaccaatctc gtaaacggcc acaggataaa 3644161 aacgacgtat cctatcacaa tatgaaactt aaaccatagc gggacactct ccatcaaaga 3644221 ggcgtcaggc ctgaacaaaa cgatttccct gaaccagggc ccgactgtgg tccggtaatc 3644281 aaatcctttc gaatcaatgt tgagaaacgt ggccgcaacg cctgacagca tcatgaacag 3644341 cagcaggagg agcgtaagga tatcggatgg cgagctcgtt ttgcggattc ttttgtcaaa 3644401 cagccttctg tacgtcagga tgacaagtcc ggtacatgcc gcaatgcccg ccggcaagcc 3644461 agcgccaatc gccattttgt gatacatatg ctctgaaatg ccaagggaag catacacgcc 3644521 ttctgggatc agaatcccca tgacatgccc gccgacaacg cacagcagtc cccagtgaaa 3644581 aagtgtgctg ccagccgcaa gttttttctt ttctaacagc tcgcttgatt tcgccgtcca 3644641 gccaaattgg tcatgctgat agcggtaaat atggccgccg ataaagattg tcaatacaat 3644701 gtatggcata ataccccaga ggatctgccc gctcatgcct gaacagcccc ttcaacgctt 3644761 tcacgtacgc caatgttttc aagcgcggcc agcagcacgt gcagcagttc agcgtatata 3644821 ctgtcatttt tttcgagacg ggatgccagc tccctcacat tggacagata tttctcaaac 3644881 acgcttctcg ctgcttcaat ttctgcagcc gcagcaaatt ccagcatcag cggcagataa 3644941 tcaggcagct ctttctctgt cggcaggaaa ccggattgct cgtatgtgtt ttttaaatgc 3645001 agcaattcaa tgccgcgttc cctttgctcg cctgagttaa agtaggtgac atacatattt 3645061 gtttttttcc cgaagtcgaa tgtatagaca tagtgttcaa tcagcgcttc cggagaatag 3645121 ctggctgacg tctcgaaaaa gtgcagcagc ttctcccgga tttgccggtt gccgatttct 3645181 tggataagag ccttccaatc gggaagctcg gctctccact cttcatccgg ataagagaga 3645241 agacaggaaa gagcagagaa cgtgatttgc cggtctgtgg tgttcatctt gttacacctc 3645301 atttatcaaa agttagaaac aggagccggg gccgcctgaa aatgataagc cgcagcttcc 3645361 ttgttcagcg tataaatctg atacttcttc tcgatggctg ctcggaatca caaagcggtc 3645421 atcatatttg gcaatcgcaa gcagccgata catatcttca atttgctgtt ctgttaagcc 3645481 gacactggag atcagttccg gatcgattga tttattcgtc tggaccgctc tcatatactg 3645541 gcgcatgaca gacattttct ttaatgttga ccgaatatga tccgtatcac cggctgttaa 3645601 cagctgcgcc aaataatcta tcgggattct catttggtcg atagccggaa aaatatcttc 3645661 cgccgtttgc cggctgcctt ttccttcaaa gagattcata atcgggctga gcggcggaat 3645721 gtaccacacc attggcagcg tgcggtactc aggatgaagc ggcagcgcga tcttccagtc 3645781 aatgatcatt ttatagatcg gtgattgctg cgcggcctct atccattcag ccggaatgcc 3645841 ttgttctttt gccagtttgg caacctcagg atcattcgga tcaagaaaaa cgtccaattg 3645901 ggaatggtag agatcctttt cattttcaac agatgccgct tcctccactt tgtccgcgtc 3645961 atatagcatg acgccgaggt agcggattct gccaacacac gtctcagagc agatggttgg 3646021 cagtcccgcc tccaaacgcg gaaagcagag tgtgcatttt tccgctttgt tcgtttgcca 3646081 gttaaaatag acttttttat aaggacagga tgagacgcaa tatctccatg aacggcatgc 3646141 gttttgatcc acaagcacaa tgccgtcctc ctcgcgtttg tacatggcgc cggatggaca 3646201 ggatgagacg catgccgggt tgatgcagtg ctcgcaaata cggggcaaat acatcataaa 3646261 gacgtcatcg aattctgttt tgatcgattc ctccatcttt tgtacgttgg gatcttcaag 3646321 tcccgtaatg tggccgcctg cgagatcgtc ctcccagttc ggtccccatt cgatattcat 3646381 gaaatccccc gtcaaggacg atttcgggcg tgctaccggc tggtgttttt tctgcgggct 3646441 gttcgttaat gtttcataat catagttcca aggttcatag taatcatcaa ttgacggctg 3646501 attcggatta tagaaaaggc ctgcaagccg attggttttc gagcccgatt tcagctcgag 3646561 ctttcctttt ttcaatgtcc agccgccttt atatttgtcc tggtcctccc attgcttcgg 3646621 gtagccgatg cccggctttg tttctacatt attgaagtac atatattccg caccggaacg 3646681 gtttgtccac gtgtttttgc aggtgacgct gcacgtgtgg cagccgatgc atttatccaa 3646741 gttcatgacc ataccgattt gcgctttaat cttcaagcca atcgacctcc ttcagcttgc 3646801 ggatgacgac gttcaggtcg cgctgattcc ccgttggacc gtaataatta aagccgtagc 3646861 tgagctgggc gtagccaccg atcatctgtg tcggcttgac gtgaatcctt gtcgggctgt 3646921 tatgggtgcc tccgcggtta ttcgtcagct ttgtgccggg cacgttgatg tggcggtcct 3646981 gggcatggtg cataaacgcc attcctttag gaatccgatg agacaaaacg gctctcgcga 3647041 cgacaacgcc gtttcggttg aagcattcaa tccaatcgtt gtctttgata tccgtgtcct 3647101 ctgcatcatc tttattcatc cacacggtcg gcccgccgcg gaacagcgtc agcatcggca 3647161 gagaatcaaa atacatgctg tggacagacc atttattatg cggcgtcaaa taattgagga 3647221 cgatttcttt tccctcttga tcaggccgtt tgctcagaaa cgggcgatgc tggaggatcg 3647281 gtttgaatgt cgccatcgtt tcaccgaatt ccatcatcag ttcatgatcg acataatagg 3647341 attgtctgcc tgtcagcgtc cgccacggaa ttaatttttc aacattcgtt gtaaacggcg 3647401 aatacctgcg ccctcctttt tcagagccgg taaacgctgg agacgtgatc accgttttcg 3647461 gctgggctgt aatttgttcg aacgtaaagc attcttcctc gcgttcttcc gccaggtctt 3647521 tcagcttcag gttcgtgatg ttttcaagtg attcccatgc ttttactgcg acctttccat 3647581 tcgaagtgga tgatagggtt aaaatcgctt ctgcagcctg ctttgcttca cttatatttg 3647641 gacatccctt tgccacgctg tccgaggtga tttctcccag tctctgtttg agtgattcat 3647701 attcatcggc tattgaccag ctcatccctt ttgttccgct cggctttaaa gcaacgttcg 3647761 gaccaagtgc agtcatttta tgaaaaatgt gtttgtaatc ccgttcaacg acttggatgt 3647821 tcggcatcgt ttttcccgga atggcttcac attcgccttt gctccagtca ttgattttgc 3647881 cgaatggctg ggccaattcc tgcatggtgt cgtggagcag cggtgtcgca accacttctt 3647941 tcaccggctc catatcgact tcttctgcca gatcggaaac ggcttttgac agcgccttga 3648001 aaatatccca gtctgacttc gattcccacg gagccgagat cgcaggagca aatggatgaa 3648061 tgaacggatg catatctgtg ctgctgagat cgtgtttttc ataccatgtc gccgccggca 3648121 gcacgatatc ggaatacagc gccgtacccg ccattcgaaa atcaagattg attaataagt 3648181 cgagctttcc ttccggcgcc tgctcccgcc atttgatttc ttctgggcgg atgctgtcgc 3648241 tgtcgtcatt cattaaaccg ttcgttgtcc ccagcaaatg cttgagaaaa tattcatgcc 3648301 cttttcctga gcttgagatc agatttgccc gccatacaaa gagattcctt gggaaattca 3648361 cttcattgtc aggatcttca atcgcgaatt tcagtttttt ctcttggagc tgtgaggcca 3648421 cgtacgcacc tacgtcttca ggtgttgctg cccctgcttt ttcagcttct ttatacagat 3648481 cgatgccatt ttgattgaaa gtcgggtaag acggaagcca ccctagccgc gccgccagca 3648541 cattgtaatc agcgtggtgc ttgtagcggg atgaagcagc aatcggtgat gccaaatcac 3648601 tgatcggctg gtcctcataa cgccactgat ctgtcgcaaa gtagaaaaat gaggtgccat 3648661 tttgcagctt gggcacgcct tcccagtcct ttgcagttgc aatcgtctgc cacccttcag 3648721 caggtcggag cttttcctgc cccacgtaat gggcccagcc tccgccgttt acgccttggg 3648781 cgcctacaag taaaacaaga tttaacactg ctcggtagat cgtgtcggag ttgaaccagt 3648841 ggttaatgcc ggcccctacg ataatcatgg accggccgtc tgtatcgatc gcattttggg 3648901 caaactctct ggcaatctta acgacagctt cttttttgat tcctgtcatt tgttcctgcc 3648961 aggcaggcgt aaacggctca gggtcatcat aggagacagc cgatcgttcg ccgatgcccc 3649021 ggttcacgcc gtagttagcc agtatcaagt caaacacggt cgtgatgtac gtttcttcac 3649081 cgttcaggtt cattttttta ataggaagat cccgctcgag cactttgttt ccgtcatttg 3649141 aaaaatacgg gatgcgcacc gtgccgattt cgtcctctat tcccagcaca gagagacggg 3649201 gttcaatcgg ttccccggtt tcttcatcaa tcatgtgcag gttccatttc tgctgcccgt 3649261 cccagcgcga gcccattgtc ccttggggta tggcaaatga acttgtctgt tcatcccaaa 3649321 ccgcaggctt ccactgatca tgctttgtct tccgcccgat gtccttcgca tgcagaaacc 3649381 gtcccgctgt gtatacgcca ttttcttttg acagagtgac gagaaatgga aaatcagtgt 3649441 attgcttcgc gtactcaata aaacgttcag tttcttggtt cacgtaaaat tcctgcagaa 3649501 taacgtgacc catcgccatc gcaagcgccc cgtcagtccc ttggcgaata ctcagccagt 3649561 catccgcgaa ctttgaggat tccgcaaaat ctggactgat cgaaatgacc ttagcgcctt 3649621 tatagcgggc ctccgccaaa aaatgcgcgt caggcgttct cgttaacgga acgttggagc 3649681 cccatgtgat aatatagccg gaattgtacc aatcactgct ttccggaacg tccgtctggt 3649741 caccccaaat ttgcggggat gctggaggaa gatccgcata ccagtcataa aaactgagca 3649801 tagggcctcc gattaacgac ataaaccggg agcctgatgc gtggctgatc atggacatgg 3649861 ccggaatcgg agaaaaaccg acgtttcggt caggcccgta tttcatcact gtatacagca 3649921 gagaggctga aatcagcttc agcacctccg gccattcagc gcgcacaaaa ccgcctttcc 3649981 ctctcgcctg tttataggac ttcgcttttt cagggttttc gacgatcgat ttccaggctt 3650041 ccaatggatt ttgatgcgtc tgcaatgcct cccgccacaa attgatcagc acaccgcgca 3650101 cgtatggata tttcacacgg agcgggctgt agatatacca tgaaaaactg gccccccgcg 3650161 ggcagcctct cggttcaaaa tcaggcatat ccgggcctgt tgatggataa ttcaaatttt 3650221 gcccttccca cgtgactatt ccgtttttca cataaatatt ccagctgcaa gaccctgtac 3650281 agttgacgcc gtgggtggag cgaacgactt tgtcgtactg ccatctgttt ctgtatacat 3650341 tctcccaatc gcgatcctcg cgggtagttt ggctatgttt atttgaatgg tgttcgatag 3650401 gagagaaata attcaatctc ctaaacaacg gactcctttt ctttttcttc atgagagttc 3650461 actccttccg agtcaggtga tgctaagttc actataaaca gagacagcgt gtttccttgt 3650521 gaactatgtc acacactctg cttttttcac aaaatgttca cacaaaggag aaggaaggct 3650581 gcgttcaggc aggacgcttg ggtcattagc tgcctttcat tcaaagatca aaaaaaaccg 3650641 gctctattta agaaccgggc tcagcgtttt catcctgtga tgtatgcaga taccgcaaaa 3650701 ataattgata ggaacaaaaa acattttgct gaagcatagc caaaaagttc atttgcagct 3650761 gcggatgata agacatcatt ttcttaaata tgtaatatgg gatgttgaga atcagaatgt 3650821 ctgaagtggc attgactgag ataaagggcg ataaataaag cccgcctttt tcatcaatcg 3650881 gaaacacatc gcctttttcc cacagcgcaa cggttttcga cccttcaggg agccttgtgt 3650941 ccataaaacg gacactgcct tttaatacaa tataaacaga ttgagaatga agaaaagatg 3651001 gagactgatc acatgaaccg cggataaacg tgccgttttt cagcaaggtt tcgacaatgg 3651061 atagaggcac ttcattaaac ataggaagtt gtttcagaaa taataaatag tcacactgat 3651121 tcataggaaa acctcctgtg ctaaggatag ctttagtgta gctcgactga gcctgtacag 3651181 cagtgatgta tttcacagcc tgtatgatga atgtcactta tcaggagggt gaatgcattt 3651241 ataatgaaag aaaaaaggag gatttcgatg aaggcgctga ttccgaagca gcacggggcg 3651301 tgggcgatgc tgctgatccc atttttactc ggcatggtca agggaggccc cgttatttgg 3651361 catattccgc tcttccttgg ttggcttttc ctatacttag cggtttatcc cgttacgctt 3651421 gccttaaaaa agaaacaaag caaaccatat caaaagtgga tgtgttatta cggttttccc 3651481 acctgctgct ttttgatgat ctcggtcttt cataagccgc ctctcatctg ggtgggcgtt 3651541 tctttactgc cgctgtttct catacatatg tattttgccc gcagaaaaaa cgaacgagcc 3651601 ttattgaatg atgttgcagg tgtcttgttc ttttgttcgg gcgggtttgc gagctgctgg 3651661 ctggggatgg gaacccttga cggctgggct tggtttattt tcttgcagtc tgctttattt 3651721 tttatcggga gttcctttta tgtgaaatcg gtgatccgcg agagaaaaaa cagggcattt 3651781 gcatactggt catggggata tcacctgctg ctcccctttt tatccgctct tttcggagca 3651841 ggatgggcgt ttctcgcttt tatcccgagc agcttgcggg catggttttt tcatggaagg 3651901 gattggcccg taaaaacgat tggcattctg gaaatcgtga atgcctgctt ctttcttgcc 3651961 gtcatgtgcc tgtttatcac aaggtaaaaa aacaaggaca ccgctgtcct tgtttttttc 3652021 agtcaatatt gcaaatctcc agcgggcaat tttcacactc aatctcacat cgtaaatagt 3652081 cccgcttgtg caaaataatt tttccggatt cgtctatcga aataacccct tttttgcgga 3652141 gatctccgag catacgattg acgctttccc gtgcagccgc gcaaaacttt gccaaatcct 3652201 gatttgtcag gacaatgtta atcagaatgc cgtcgcttcg ctccactccg tagctgtttg 3652261 ataagcggat aagggtagaa tagagcgccc cctttttgcc atgaagaagc agatccctga 3652321 ttttggactg aatcttccgg aggtgcgtgc tcatccattt catgaactca aatgtcaaag 3652381 cgccgttttg gattaattct ttttccagct tatttttatt aatgacgagc acctcgccat 3652441 cctctagtac ttttgcactg agcatatacc ttggttcttc agtgaaaagt gttaattctc 3652501 cgacgatatc atgcttttgg cagattctaa gcgtcaggtc ttttccgtca gatgtcagct 3652561 tgccgatttc aatgagtcct gattgaatca gataaagctc ttctgcatcc attccttccc 3652621 gaaacaaata cgtgtgtttt tccatttttc ttttcgtgct gatcgattcc agcaattcat 3652681 acagatcgct ggatataaga tcactatcag atggtcgaac agagagaaaa ttcatgagct 3652741 cacctcgaag aaagtcacgt tgtgtgttta ttgtaacgtg aattgatttg tacccatcga 3652801 gaaaaaacta acaatcttgt gaatgcccca gtgttagttg atgctctggc tgtttctctc 3652861 cgtgtgtgtt ttcattcttt cctgccaata catccatatg acaaggacaa aactggctaa 3652921 cgccacctct gaaagcgcca taaacccgat cgcgtactgg cctgttgcct gaaatacact 3652981 cgccaatatg agcggaggaa aaaagccgcc taaaccgccc atggcagaca caatcccatt 3653041 ggcaatcccc gcttgcttcg aaaaatagaa aggcaccagt ttaaaaacag ttccgtttcc 3653101 tatgcctgag cagacggcca cggttaatga tccaaacgta taaaggccga ttgtcggcga 3653161 gaacgatagg ataatgcctg ataatgtaag cccggcaaaa acaaacatca agatgcggag 3653221 cgggctcatt ttatcagcca ggaatccgcc cgcaggcctg agcagcgtag aaaccgcaat 3653281 aaagccagcc gtccgcaagc cggcatctgc aggattcagc ccaaaatgct ccaccagaaa 3653341 gttcggcaga tagatagtga aggcgacaaa ggcaccgaac gtaataaaat aaaacaggct 3653401 cagaaaccat agcacatgat ttcggtaaac agctttgatt tgagtcttaa cagaaacttt 3653461 gaccttcttc tcatgcctgt cgccaaacaa tacgtgcagt aaggcaaaga cagccagcaa 3653521 aatcagatac atttgcacgg ttgatttcca cccgacggct tgagcgataa ccggcgctgc 3653581 aaatgtcgta acggctgtcc cgatatttcc tgcaccgtaa atcccattga cgacaccgtg 3653641 cttttctttc ggataatatt tcgggaggga ggtcacccca atggaaaaca ccgctccccc 3653701 gatccctaag aaaaagccgc ctgcgattaa atcaaacaga gaatccgcga tactgatcca 3653761 aaatacagga aataaaagca ggatgaagct gaccataaac atgagccgcg cgccaaacct 3653821 gttcgttaaa taccctaaag gaatgcggag aagcgacccg aggatcacag gaatcgcggt 3653881 cactaaagaa atctcaccct tgcttaaatg aatatctaat gtgatttggg aaatgagtga 3653941 tgaaatcagc acccaaacca taaaccctgc caccaagctt aatgactgta acgataattg 3654001 aatgtgttga cggttgatca tttggcttgc ccctttcaat gattcaataa tcagtcttat 3654061 catacaaaaa ctagccaaac aggattgtga attacatcac acgtttttct cataaaaaaa 3654121 ggacaaagcc cgaagacttt gtccttttga tcgtgattac attttttccg gagccgatac 3654181 gccgatcagc tgaagcgcat tgttcagcgt aatttgcgtt gccttcatta aagccaggcg 3654241 cgcgcggctt ttctcttcat tttcagggtc gatgactttc tctgcgttgt agaagctgtg 3654301 cagagcagaa gccagatcat aaatatagtt agtgacacgg tgcggaattc gtttttccgc 3654361 tgcttccgcc actgcctctg ggaagccgcc gatcgttttc agcagatcgt attctttttc 3654421 tgattgaata tggctgaaat caagatctgc cgccggttta agcccctgct cttccccttg 3654481 gcgaagcatg ctgcaaatac gggcatgcgc gtattgtgca taatacacag ggttttcgtt 3654541 agatgttgat acagcaagat ctaagtcaaa atccatatgg gtgtctgcac ttcgcattgc 3654601 aaagaagtaa cgcacggcat ccaagccgac ttcttcaatc aggtcacgca tcgttacggc 3654661 tttaccggtc cgtttgctca ttttcatttt ctcgccgttt ttgtaaaggt gaacgagctg 3654721 aatgatttct acttcaagcg ttcctttttc atagcccagc gcttcgattg ccgctttcat 3654781 acgcgggatg tagccgtggt gatcggcgcc ccaaacgttg atcagcttat caaagccgcg 3654841 gtcaagcttg tccttatgat acgcgatatc aggaagaagg tacgtgtacg tgccgtcctt 3654901 cttgatcaat acgcggtctt tatcatcgcc gaaagtcgtg gaacggaacc aagtcgcgcc 3654961 gtcttcttca tagacgtggc ctttttcgcg gagcgcttca agcgccttgt cgatttttcc 3655021 attttggtac agtgaagttt ctgaatacca cacatcaaac ggcacacgga agttttccaa 3655081 gtccttgcga agcttttcca gctcgtattt caggccgtat tcacggaaaa acgcgaggcg 3655141 ttcactttcc tcttcgttaa cgaaacgatc accgtattcc tcagcgagac gctttccgat 3655201 cgcaatgata tcctcaccgc ggtagccatc ctccggcatc ggtttttcca atccgagtgc 3655261 ttcaaagtaa cggacttcaa cagaaagcgc cagattgttg atttggtttc ccgcatcgtt 3655321 aatgtagtat tcgcggctta catcgtaacc cgcttttgaa agcacgttgc acaaggaatc 3655381 gccgacagcc gccccgcgcg catgcccgag gtgaaggtct cccgtcggat tcgctgatac 3655441 gaattctacc tgaactcgtt caccgtttcc gatgttcgtt tccccgtatg cttcccctgc 3655501 ttccagtaca gacggaatca gctttgttaa atattgattg ttcatataga aattgataaa 3655561 acccgggccg gcgatatcca gtttttcaat cgaagccttc cctttatcaa aatgggcgac 3655621 aatctcttca gcgatttgac gcggcgcttt ttttgccact cttgccaact gcatcgccat 3655681 attcgttgag tagtcgccgt gtgttttatc tttcggtgtt tctaaaacaa cattgggaat 3655741 ctggctttct tcagccagtc ccgctttcag aacggccgct ttgatttctt ctttcagcac 3655801 gtccttcatt tgttccgcaa tgttcatgcg tgagttcctc cctcatacgt gatcgtcata 3655861 ttatgtaaat gctcctgctc gtctccgaca tgcatgtcat atgcgatgct gatacggcct 3655921 ttttcttcat cgagatcaga ttgaatcgat tttgtgcttg ttttcagctc aagctcacca 3655981 aatgacattt tatatttagc aattgtggaa gctcccgtta cgaaacgctg attcattttg 3656041 acagcgcctg acctcatgac caggacttcg ccttcgctta ctttcacaat cgttttgact 3656101 ttgcctaagt cgtgttcttc ataataagat agatacactt tattttgttt tacatagtaa 3656161 aatccggtgg tgcggaattc gatgacttct tggtttccgt catcctcgat cacagacttc 3656221 acatggagtg ttatcggtgt ctcttgcttc attctgacac gtccttttca tcattccact 3656281 ttgacttgaa tagtataatc attcggtttg taaacttcaa ctgcttctat cttaccatca 3656341 ttgctcatca gatttgaaga taaacctcat aaaaagcatt tccttatata gaagagaaaa 3656401 tcatatcact aattaccttt aggaaatgtt acatttttcc gaaatctatc atttcctttt 3656461 cacatttttt tcaaaatata tgtattgaat tagtaatttg atagttttaa gataaaagta 3656521 caacatagat ctgctagaaa aacaaaaaaa gggaggattc aattatgaaa aaagctgtca 3656581 ttgtagaaaa caaaggttgt gcaacatgct cgatcggagc cgcttgtcta gtggacggtc 3656641 ctatccctga ttttgaaatt gccggtgcaa caggtctatt cggtctatgg gggtaaggat 3656701 ctcccaaaag ggcatagtca ttctactatg ccctttttaa gtaaattaca atttttaact 3656761 aaaatctacc tcttggatat acatacacaa ccgtttttca tttgaatcat atgtataggg 3656821 gatggtattt tgtttataga gcagatgttt ccatttatta atgaaagtgt aagagttcac 3656881 cagcttcctg agggcggcgt gttagaaatc gactacttgc gcgataatgt ctccatttct 3656941 gactttgagt atttggatct caacaaaacg gcttacgagc tctgcatgcg catggatggc 3657001 caaaaaacag ctgagcagat tttagctgag caatgtgcag tgtatgatga atcaccggaa 3657061 gaccataaag attggtatta cgacatgctc aacatgctcc agaacaagca ggttattcag 3657121 cttggaaacc gggccagccg ccatacaatc accacgagcg gaagcaatga atttccgatg 3657181 cccctgcacg ccacctttga actgacgcac cgctgtaatt tgaaatgcgc ccactgttat 3657241 ttggaaagct cacctgaagc gctcggcacc gtgtcgattg agcaattcaa aaaaacggct 3657301 gatatgctgt ttgataacgg tgtattgaca tgcgaaatca caggtggaga aatttttgtc 3657361 catccaaacg ccaatgagat tcttgactat gtgtgtaaaa agttcaaaaa agtcgctgtc 3657421 ttaacaaacg gaacactcat gcgaaaagag agcctggagc ttttgaagac ttacaagcaa 3657481 aaaatcatcg tcggcatttc tctagatagt gtcaattccg aggtccatga ctcctttaga 3657541 gggagaaaag gctcttttgc ccaaacttgt aaaacgataa aattgttgag tgaccacggt 3657601 atatttgtca gagtcgctat gtctgtcttc gaaaaaaaca tgtgggaaat ccacgatatg 3657661 gcccaaaagg ttcgggatct cggggcgaag gcgttttctt acaattgggt tgacgatttc 3657721 ggaagaggca gggatattgt ccatccaacg aaagacgccg agcagcaccg caagtttatg 3657781 gaatacgagc aacatgtgat tgatgagttt aaagatctga ttccgattat tccctatgag 3657841 agaaaacgcg cggcaaattg cggcgctggc tggaagtcca ttgtgatcag tccgttcggc 3657901 gaagtacgtc cttgcgccct ctttccaaag gaattttcat tgggaaatat ttttcatgat 3657961 tcctatgaaa gcatctttaa ctcccctctc gtccataaac tgtggcaagc gcaagcgccg 3658021 cggttcagcg aacattgcat gaaagacaaa tgcccgttca gcggctattg cggaggctgt 3658081 tacttaaaag ggctgaactc taacaaatat caccggaaaa acatttgctc ttgggcgaaa 3658141 aatgaacaat tagaagacgt ggtccagctt atttaggagg gaaacgattt gtcaccagca 3658201 caaagaagaa ttttactgta tatcctttca tttatctttg tcatcggcgc agtcgtctat 3658261 tttgtcaaaa gcgattatct gtttacgctg attttcattg ccattgccat tctgttcggg 3658321 atgcgcgcgc ggaaggctga ctcgcgatga gcattttgga tatacacgat gtatccgttt 3658381 ggtatgaacg ggacaacgtc atcttagaac aagtggattt acatttagaa aaaggcgccg 3658441 tttacgggtt acttggggta aacggcgccg gaaaaacgac actgattaat acgctgacag 3658501 gcgtgaaccg caatttcagc gggcgtttta cactgtgcgg aattgaagcg gaggccggca 3658561 tgccgcagaa aacatcagat cagctgaaga ctcaccgtta cttcgccgcc gattatccgc 3658621 tgctatttac agaaattacg gcgaaggact atgtgtcttt cgtccattcg ctttatcaaa 3658681 aggatttttc agagcagcag tttgccagtt tggccgaggc ctttcatttt tcgaaataca 3658741 tcaataggag aatttcggag ctgtccttgg ggaacaggca aaaggttgta ttgatgacag 3658801 gcttattgct gcgcgctccc ctgtttattt tggatgagcc gctcgtcggt ttggatgtgg 3658861 aatcgataga ggtcttttat cagaaaatgc gtgagtactg tgaagcaggc ggaaccattt 3658921 tgttttcttc tcatctgctc gatgtcgtgc aaagattttg tgattatgcg gctattcttc 3658981 acaacaaaca gatccaaaag gtcattccga ttggagagga gaccgatctg cggcgggaat 3659041 ttttcgaggt gatcggccat gaataacata atccctatca tgtctttgct gttcaaacag 3659101 ctttacagcc ggcaagggaa aaaggacgcc atccgcattg ccgcaggcct tgtcattctg 3659161 gccgtgtttg aaatcgggct gatccgccag gccggcattg atgaatcggt gttgcgcaaa 3659221 acgtatatca tactcgcgct tcttttgatg aacacatata tggtgtttct ttccgtgaca 3659281 tcacaatgga aggaatctta tatgaagctg agctgcctgc tgccgatttc ttcacggagc 3659341 ttttggctcg cccagagtgt cgttttgttt gtcgatacct gtttgagaag aactttattc 3659401 ttttttattt taccgctgtt cttatttgga aacggaacgc tgtcaggggc gcaaacattg 3659461 ttttggctcg gcaggttttc gttttttacc gtttactcca ttattttcgg agttgtgcta 3659521 agcaaccact tcgtcaaaaa gaagaacttg atgtttctgc tgcatgcggc gatattcgcc 3659581 tgtgtatgta tcagcgccgc tttgatgccg gccgccacga ttccgctttg cgcggttcat 3659641 atcctgtggg cggtggtcat tgactttcct gtctttctgc aggcgcctcc gcagcagggc 3659701 aagatgcatt catttatgcg gcgatctgaa ttttcgtttt acaaaagaga atggaaccga 3659761 tttatctctt ctaaagcgat gctgttaaat tacgcggtaa tggcggtatt cagcggcttc 3659821 ttttcgttcc agatgatgaa caccggcatc ttcaatcagc aagtgattta tatcgtgatt 3659881 tccgcgcttt tgctcatctg ctcgccgatc gcccttttgt attcgattga aaaaaatgac 3659941 cggatgctgc tcatcacgct tccgatcaag cgaaaaacga tgttttgggc gaaatatcgc 3660001 ttttattcag gcctattggc aggcggattt ctccttgtcg tgatgattgt gggtttcatc 3660061 agcggccgtt cgatttcagt tctcactttt ttgcagtgca ttgagttgct gctggcggga 3660121 gcgtatatca ggttaactgc ggatgaaaaa aggccctcct tcagctggca gacggagcag 3660181 cagctatgga gcggtttctc aaaatatcgg tcttatctgt tttgtcttcc cctattctta 3660241 gccatattag ccggcaccgc tgtatccttg gcggtcattc cgatagccgg tctggtcata 3660301 gtctattacc tgcaaaaaca ggatggtggt ttctttgata caagcaaaag agaacggctt 3660361 ggaagttaac ctgctgaaga ctcatcaatt ttcaactatt tcaatcgccg cgagctttct 3660421 gaaaccgatc gaaagcgcgg cggaacctga ggaagaaacg atttattttt acggcgccgc 3660481 cgcatacctg aaggagcaaa tcattgacgc ttttggttat gctgccggca gccgtttcat 3660541 gtactcagcg aatctctttt ttgatcagca gctgaaaacc tgcgggaccc gtttgattca 3660601 cccattatat aacgggaatc ttcatgttga cgccctgatg aaaacttttg cagacttgtc 3660661 tttcccttct tctctttcat tcgaagcatt tgaaaaggcc aggaatgagc tgctgctgaa 3660721 aatcgaaaag aaattcactg atcccttctc ctactcggcg gctcgcttgg ctgaggaggt 3660781 cttcggaaac ccgatgtacg gcacaggcat gtttggccgg agagacagga taaaggcgat 3660841 tcatcctaaa cggtttctcg acgcaacgga ctttatcgtt gatttagtgt cccagcaaaa 3660901 acagctgaac atattgggac aagtacaagc atgtgatgtt cggggacatg ccccgcaaac 3660961 gtccgctgta acgtccggaa gaatacccgt aaaccggcat gtttttgaaa cagagacacg 3661021 cagcgctgca ggtccttccg tcttgacact cggatttgac tgcggagaga tgaaagatgc 3661081 cagcgattat atcaaaatac agctaataga cggattactg ggaaagtacg gccattccgc 3661141 tttattcaag cacttcagag agaaggatct ggcagtctat cacgttatca cccgttacga 3661201 tgtcatgaac aatttgctgc ttgtttcaat atgtacagat cagcttcatg agaaagacat 3661261 tcccccgcgc gttttggaag ctgtctcagc ttttcataca gatgagcggg aactagaaca 3661321 ggcaaagcag tttttacgca atgaattgct gctgcaattc gattctcccg aaggtctatt 3661381 ggcctatatg ggggtcctgc gccgcttctc ctgcacgaaa gaagccttgc tggatggcat 3661441 ctcagcggtt acatgccgtg atgtattgca attcatagcg accatcaatt atatcggagc 3661501 tcatgtagta aggggatgaa gagatggaaa agaaagcctt ttttcaacag ctggatgaac 3661561 gaaccgatat cagatacaca gacagcggac taaaaatatt cagattgaaa ttcccccgcg 3661621 cccacctgcg gctgtgcaat gtaaaaatcg attttggaag ccgggatgta tgtatacggg 3661681 cagaatccgg tgatacactg cttccgtatg gcacagcaca ttttttagag catcttctct 3661741 tctggcataa cggccgcaat ctgtacagtg atttttttgc gcatggcgcg cttttaaacg 3661801 cattcactac ctacaccgat accaatttca tgtttacctc attaccggat cggctcagac 3661861 aaacgattcc catcctgctt gatgctttat ggaaccactc atttgacaag aagattgtcg 3661921 ctcaggaaaa agctgtgatt acaagcgaaa ttcaaacagc acaccttaac catcagctct 3661981 catatcatta tcagctgatc agcatgcttt ctccctcctc accagctgcc gttttccccg 3662041 caggcagaat cgaagatatt gaggcgctgg acatcagtga tttacaaaaa gcctataagg 3662101 ctgcctacca agcccatcgg atgacgctgt ttttgattgg gggctcagaa aatacagaaa 3662161 cgcttttgcc tcctcacctc cagctggaaa agcgtccgga ttatcatgct gaaagaaaaa 3662221 tcatcccggc atgccctcca gtcctctcac aaaaaatgat gctgggtgat gaggagcgga 3662281 tggaagatac ctggaccgga ttacagatcg gcgcacttcc cgggcaaaac gatctgttgt 3662341 cgataaagct ttattgggat atcgcggctc gtattctatt tcaattagat tcaccgtttt 3662401 ttcaagagat tcagcaaacg taccgcctgg aaatcgatcg cttgtcagcc gagacttata 3662461 tatatgagga tggcggtttc ttgatccttc acagtcaagg gacccattct tcagcttata 3662521 tcgatgtggc ttcatactat gtcacacaga agaaagaaca ggttgccgcc tggcttcaat 3662581 acggcaagga ctctttgaca gacgcgatca tttatgacag cgattatgtg cgtaaatgct 3662641 tcgagtgggc agccgagtgt gacaggtgcg attgctcgtt tcttgacatg taccacatca 3662701 ttcaagatat ggatgcgcag gttttcttgt ctctcattga tgcaatggca tcttctaaca 3662761 aagcgatcat tcacgtttct cagaaagagg cgatcagaca atgaaacaaa gcactgtctt 3662821 taccctttta ttgctgctta taggtatggc ggcttattcc ttcggctggg ttcaggccgt 3662881 tgccgaagcc gccgcccaat atgtacagat gatcaacaat gatgctgtgc ggctcggact 3662941 gctggcttgt accgctgccc tcctgatgct gcctgctttt ctctatcttc actatgtcac 3663001 ccaatccgtg aaaaacatga cagcagcttt tcagaaactc acacagtctc atcaaagctg 3663061 ctgtgacttt cagcaacaca acttgtgcag ccgatatgca gaagacgtca aatcgctgcg 3663121 tgacagctat aaaaacgtcc gccaaacata cgtgatggct gccgtgttgt gccaagtcat 3663181 catattcggc tgcatgttcg aaatcgttaa agccgtccct ttccgccttc atacgccccc 3663241 tgccttttca atgggacttg cgatgctact gatcctgtat ttattgtttt gcatgcgaac 3663301 gtatttgcgg cagcttttcc ggcacggcag cctgttcaga aaagtgtttg cgggagcact 3663361 ggcagcagcc gggatttggt ggatgctcag tttctctata agtgaactgc tgtttctgat 3663421 tatcctggct gccattcagc aaatcggatc atttatttat aaacgattct cttatcacag 3663481 caccgcttct cttgatctat aaaatagcta catcgcaatc gcagacggac ccgcgccaac 3663541 cggaatcacc gtcacggctg tataatcact tgtgcggtac acggtcacag cattgtcgtt 3663601 gggctgtgcc gcataaatat actgtttgtc cggcgttacg gcgaggtcaa aggcgccggg 3663661 gagagacacg tttgcaatga tcctctgtct ggccgtatta actacgtata agttattaat 3663721 gagaaacggt tcactatatg gctctagaaa ataagctcta gtactatcga gagaaaatac 3663781 aatcgtcctc agcgtttcaa ataaacggct gaagtcccct cccctgctta atggtgacaa 3663841 actaatctcc gttacacctt tcggccacag ctcaccattc aatacgtacg caaaatttcc 3663901 agcgtaagga gttgtaatta aactgggaaa ttcaaatgta tctatgatac tttctaccaa 3663961 ctgcccagta tttacatcat atttatcaac cgaccaactg cttccattag cggtatagac 3664021 atactgtcca ttcggatcaa gagcaaagtc taaagcgccg ggtatcggaa tgacatcaat 3664081 gaccgattga gaggccgtgt taatcacata tatagatccg gcggccatca cgtatgcgaa 3664141 ctcatctgtt ggatcaaatt cgatttttct cggccctcct ccaacagtaa tggtatttat 3664201 gatggttaat gttttattat caatcactga gacaaggttg gtatttccat ggaggacata 3664261 cgtgaatgct ttatcgaaag taacgcctag attagttggc acgtcagaaa aagggattgt 3664321 ttttacaaca gtgtttaaat ctgcatcaat aaccgaaacc gtgctgtctc cagtattggc 3664381 agtaaacaca tacgattgag ggtctggtga tggcggtaaa acaagtgtcc cggccaccgt 3664441 aagcggactg ccgtagaaag gcggtacaat gagcagatct tccactgtta tttgactgaa 3664501 atcaggacag cggccagact gtgctgcata ataaacaact tgatcaatct cttcagtatg 3664561 aatcacagaa acagccccgt ctccttgtcc atattgattt cgtacaggcg acacactgac 3664621 aagaagcgta atggtccctt gtactctcac agcatatcga acaccgatat cttctggttc 3664681 cggcccagtc tggattaagc aaggctcact gatacaggac aaattgtctg tactccatgt 3664741 aacagccgct gacgcttcgg ccgtatcaac cttgaagccc tcagggaaat ctatcggcac 3664801 ttgaaacggc gcttcccggc taatttcctc atcacaaaaa cagaaacaat tttcctgtaa 3664861 agcagaaaga tcattctttt tcatgatttc acgtcctttt agaaatgcac aacatgcagc 3664921 ggttaaatcg taatggcacc cggtgaaacc ccaagagata tcacagtttc ctcagaataa 3664981 tcatctgtgt tgtaaacaat gatgctctgc tctataaaac gagttgcata cagaaaatcg 3665041 ccattcgggg taaacgcata gtctgttgct gattgcggaa catttcctat aacgcctgct 3665101 ccatttggac tgacagaata taaattgcca gtgaagccgt catataaata cacctctgct 3665161 ccactcgtaa acattcgata ttccccttca tactccagct cttgggtgct gctgatggta 3665221 aacgtattta aatcaataac cgtcaaataa ttaaaaaaga attcttgttc taatacatag 3665281 gcataccgct ccggccaatt tgtttctatg gttgatacga taagctctcg ttcaattgtt 3665341 cctgtgactt caccggtagt taggtccact ttttgcacta ttccaaaatt cagaacatag 3665401 gcgaataacc cattgggatc gattgcaaca tcatatcctt ccacaggaat cgacctatcc 3665461 acagttaacg tatcaattcc aatcacataa accgcagtac cggtgaaaac ataagcaaac 3665521 tcatgattag ggataaatct aatcaatcga ggcggctgat ccagcaatat agttgctgtc 3665581 actgttaatg tgtcataatc gatgacagaa atcacattat tgttgggatg taagacaaac 3665641 acagcgcttt tatctggcgt aatttcaata cctgccggat tgtacggaag agcaatcgtt 3665701 gtcacaacag tatcggtgtt tgtatcaatc acagaaactg attgatcatt tggattcgct 3665761 gtaaacgcgt agacgggttc cggctccggt acaagcacaa ttgtccccgt caccgataaa 3665821 ggactgccgt aaaacggcgg aacaacaaca aggttctcaa tcgtgatgtc actgatatcc 3665881 gggcaatcat ccgattcatc ggaataatag acgacttgat cgatttctgc attgtgaatg 3665941 acggaaacag ccccgtcccc ttgtccatat tgatttcgga caggtgagac actgacgagt 3666001 agcgtaacgg ttccctgcag gcgcactgca aattgaacac cgacctcatc aggctcaggc 3666061 cccgtttgaa ttaagcaacg gtcactgaca caagaaaggc tgtctgcatt ccacgtcacg 3666121 tttgcaacag cttcagccgg atcaacgaca aacccttcag gtaattcaat cggtgcttga 3666181 aacatggctt ctcggcttgc ttctccctca caaaaacata agcactcttc ttgttctgct 3666241 cctgcttttt ctttaaagga aagcttgttt tttctcattc cttcacttcc ttttcagaca 3666301 tacactgctc acgcagatat aacagaatat ggaagggtaa cgtgtttgct tgtacaaatt 3666361 gctgagggta aacgcttctt tttgaaaata tatctccaaa catgcggtgt aacgaaagaa 3666421 aaaattgcgg tttttttgcg cttctcacaa gaatgttgat gataaaatat gacatatata 3666481 gaattatgaa gggagggatt tgcaaacgtg acaggtgtca tatcttcttc ttccatcgga 3666541 gaaaagatta acgaatggta tatgtacata cgccgattca gcatacccga tgcagaatat 3666601 ttgcgacgag aaatcaagca agagctggat caaatggaag aagatcaaga ccttcatttg 3666661 tactattcac tgatggagtt tcggcacaac ctaatgcttg agtaccttga accgttagaa 3666721 aaaatgagga ttgaggaaca gccgagactg tctgatctgc tgcttgagat tgataaaaaa 3666781 caggctcgtt taactggtct gcttgagtac tattttaact tcttcagagg catgtacgag 3666841 ctggaccagc gggaatatct gtcggctatt aaatttttca aaaaggccga aagcaagctg 3666901 atattcgtta aggatcggat agagaaagct gagtttttct ttaagatgtc tgaatcttat 3666961 tactatatga aacaaacgta tttttcaatg gactatgcac ggcaagcata tgaaatatac 3667021 aaagaacatg aagcttataa tataagattg ctgcagtgtc attctttatt tgccaccaat 3667081 tttttagatt taaaacagta tgaggatgcc atctcacatt ttcaaaaagc ttattctatg 3667141 gcagaagctg aaaagcagcc ccaattaatg gggagaactt tgtacaatat cgggctttgt 3667201 aaaaacagcc aaagccaata tgaggatgcc ataccttatt tcaaaagagc aatagctgtt 3667261 tttgaagaat caaatattct tccttcctta cctcaagcgt attttttaat tacacagatc 3667321 cattataaat taggaaaaat agataaagct catgaatatc atagtaaggg aatggcttat 3667381 tcacaaaagg ccggagatgt aatatattta tcagagtttg aatttttgaa atctttatac 3667441 ttatcaggcc cggatgaaga agcaattcaa ggattttttg attttctcga aagtaaaatg 3667501 ttgtatgctg atcttgaaga tttcgctatt gatgtggcaa aatattatca tgaacgtaaa 3667561 aattttcaaa aagcttctgc ttattttttg aaggtggaac aagtaaggca acttattcaa 3667621 ggaggagtga gtttgtatga aattgaagtc taaactatta ctctcttgtc tggctctaag 3667681 cactgtgttc gtggcaacaa ctattgcaaa tgcacctaca caccaaattg aagttgcaca 3667741 acgaggaatg atttaaccgc cgtccatcgg cggttttttc gtcccctctt taccaaagtc 3667801 tcccaatcca tgctatgatc ttttcaataa tcttgaagag agtggaaatg cagcatgtct 3667861 ctaaaaagtg tgagaaccca ctttactcaa tggaatcgag aaaatgatgt gacggagttc 3667921 gaaacgtcga gtgcgacagt tgaacaggca gctgagacaa tcggcgtaag cctgtctaga 3667981 atcgccaagt ccctgtcctt cagaggggaa ggagatcagg tgattctgat tgtggcagcc 3668041 ggcgatgcca agatcgacaa caaaaagtcc aggcaaacat ttggctttaa agcaagaatg 3668101 ctctctccta atgaggtgct ggagcagaca ggccatgaaa ttggaggagt ttgcccattt 3668161 ggattggctc atgatcctga ggtttatctt gatgtatcgc tgaaacggtt tcagactgtt 3668221 ttccccgcat gcggcagcag aaactccgct attgaattaa caccgaaaga attatccgaa 3668281 ttttctttct caaaagtgtg gattgatgtt tgtaaagact gggaataaaa aaacatccag 3668341 acatcgtctg gatgtttact tatttcacaa acccaagcag catttcacgg atgattttgc 3668401 tggctgtgtt tgccgtttgc tctgagtggt cgtataccgg cgcgacttcc actaaatcag 3668461 cgccctttac gtttacctct gaacgcgcaa tttcatggac cgatgcaagc agttctttag 3668521 acgtgatgcc gccggcgtca accgttcctg tacccggtgc gtgtgcaggg tctaatacgt 3668581 caatgtcaat tgtgacataa accggacggc ccgccagctt cggaagcacc tctttcagcg 3668641 gttcaagcac ttcaaatttt gagatgtgca tgccgttttc cttcgcccat tcaaactctt 3668701 ctttcatgcc ggaacggatt ccgaatgaat acacattgtg cggtccgatc aattctgccg 3668761 ccttacggat cggcgtggag tgagaaagcg gttctccctc ataatcaaca cgaagatctg 3668821 tatgtgcgtc aaaatggata atcgcaaggt ctgggtattt cttgtacatc gctttaatga 3668881 caggccatga cacgaggtgc tccccgccca tacccattgg gaacttccct ttttctaaaa 3668941 tgctgtccac gtactcttca atcatatcca ggcttcgctg cggatttccg aacggcagcg 3669001 gaatgtcgcc agcgtcaaag aagttcaagt cagccagatc gcggtctaaa tatgggctgt 3669061 attcctcaag gccgattgac acctcacgga ttctgcttgg accaaagcgt gagcccgggc 3669121 gatagctgac tgtccagtcc atcggcatgc cgtaaagaat ggcgtccgcc tcttcccact 3669181 cgggacggct cgcgataaat acttttcctg aataagcttc atcaaatctc atctataata 3669241 ccctcgcttt cctgtaaaaa agcgcaagat tcgctcctgc gccatacctt cattatttaa 3669301 tcaggtcact cacaaatttc ggcagaacaa acgccgcttt atgaatatct tttgtgtaat 3669361 atttcgtctc aatatcgaag aaacggctgt cttccactgc aagcggatca tattttttcg 3669421 agccaattgt aaatgtccac aaaccgcttg gatatgtcgg aatgttcgcc gtatacagct 3669481 tcgtaatcgg gaagatttcc ttcacgtcgc gctgtacatt tgtgattaat tccggtgtaa 3669541 accatgggtt gtccgtctgc gcaacgaaaa taccgtcttc tttcagcgct tttgcgattc 3669601 ctgcgtagaa tccttttgta aacaggttta cagccggtcc gactggttca gtcgaatcta 3669661 ccatgatgac gtcatattga ttttcagatt ttgcaatgtg cataaatccg tcatctacct 3669721 gcacgtcaac gcgcggatca tccagtttgc ctgcgataga aggaaggaac tttttagagt 3669781 attcgataac cttgccgtca atatctacaa gtgtcgcttt tttcacgctt gggtgcttca 3669841 ggatttctct gataacgccg ccgtcaccgc cgccgactac gagaacgtgc tccggatttg 3669901 ggtgcgtgaa taatgggaca tgcgccacca tttcgtgata aacgaattcg tctttttcag 3669961 atgtcatcac catgccgtcc aaaaaaagca tgttgccgaa ctcttctgtt tccaccattt 3670021 ctaaatgctg aaactccgtt tgttctgtat gtaacgtctt gttaaccttc atcgtaatgc 3670081 caaagttttt cgtctgcttc tctgtgtacc aaagttcgct caattgtcat ctccctttcg 3670141 aggctgtatt catttattgt aagcgtctta tcagctttta ttctcggttg aaatctcatt 3670201 ttcacctaag gaaaaagtat agaggatggc ggggaaaaag taaagatgcg tcctgttctg 3670261 cgatgtttaa aaacgatctt tttttctcat aatagtagaa acataaaaaa agggggaacc 3670321 cgttgtggat gcaatgacaa ataaacggct gagactgacg ctgaaaaccg ttcgcgcctt 3670381 tatcttttta ggggcttttg cggccttggc ggcagctgct gtgtttatga ctgtcatttt 3670441 gatagccaaa taccagggcg ctccctcggt gcaagtgccg caatccacga ttttgtacgc 3670501 gagtgacggc tcaaagctcg gggaaacgaa ctacggcgaa aagcgctatt gggtcccctt 3670561 aaaggacatg aatccgacga tcgtaaaagc gacagtggcg attgaagacc agaatttcta 3670621 cgatcatcac ggctttgatt ataaacgcat ggccggcgcg gcgcttgctg acctgaaagc 3670681 atttgccaag gttcagggtg caagcaccat cacccagcaa tatgcgagaa acttatacct 3670741 tgaacacgac aaaacgtgga aacggaaatg gaatgaggcg ttctacacga tccgtctgga 3670801 acaaaactat tctaaggacg agatattaga aggctattta aatacgattt actacggcca 3670861 cggcgcctac ggcattgaag cagcttcccg cctgtatttc ggcaagcatg ccaaaaacct 3670921 gacggatgcg gaggcggcgc ttttggcagg aatcccgaaa ggcccttccg gctattcacc 3670981 gtatgtcaat gagacgaagg ccaaggaacg ccagaaaacg attgtgcgga tgatggaaaa 3671041 gcagcagatg atcagccaaa agaaagcgga tgaattgatc aaggaacctc tttcctatca 3671101 gcctttgaat aaacaagttt ccaagagaaa ggctccttat ttctacgaca atgcgatgag 3671161 agagctggaa aaaaagctcg gcatgacacg ggagcaaatt gaaacgagcg ggttaaacgt 3671221 ctatacaacg gtagataaac ggatgcagcg catcgccgag gagaccatta ccgaaacggt 3671281 taacgcgggc tctgacattc aagtcgggtt ttcagccatt gatccccgca ccggaaacgt 3671341 tctcgccctt gtcggcggca gggattatca aaaaagcccg tttgaccgga cgacacaggc 3671401 gaagcgccag cctgcttcga cgatcaagcc gttgctgtac tataaagcga ttcagagcgg 3671461 atttacgcca gtcactttga tgaaaagcga agaaaccgag tttcaaattg atgcaaaggg 3671521 agaaacctat tctccaagca actataacgg atactatgcc aacaagccga ttacgcttct 3671581 gcaggcgctg gcgctttccg acaatattta cgctgtgaaa acgcatcttt ttctcggcac 3671641 gaacaaactt gtaaagacgg caaaggaatt cggcattacc gcccatcttc aagcactgcc 3671701 gtccctggca ctcggcaccg aacccgtacg tccgattgag atggtcaacg cctatgccat 3671761 gctcgcaaat ggcggaaaga aaatcgaacc gacttttatt tcaagagtaa cggacgcagc 3671821 cggccacgtg ctgtacgaaa acccgaatca gcataaacag gtgcttgatg aaaaagccgc 3671881 ttttgtcaca gcgagtatga tgacaggcat gtttgatatc gatttaaatg gatatacgtc 3671941 ggttacgggg cgaacgatag ccaaccgcct gacaagaacg tatgccggaa aatcaggaac 3672001 caccagcgca gacagctgga tgatcggctt caatccgaag ctggccgccg gtgtttggac 3672061 cggctatgac aaaaacagca ccatcgactc ggtcgaagaa aaaagctatg ctaaaaccat 3672121 ttgggcggac ttcatggagg acgcgctcaa aggcgaaccg gaaaccgcgt tcaagccgcc 3672181 aaaaggcgta accggtgtgt acattgatcc ggaaacaggc tactcatcag gtcccggctg 3672241 cgccgctaag cattacacat attttgtgaa agggacagaa cccgcaaacg tgtgctacgg 3672301 ggcagaaccc gcaaaacaaa caaaagaccg gcttccatcc aaagaaaagc ccgcttccga 3672361 gaaaaagtgg tgggacaaat ggctggggcg acatcattga aaataacccg gctcctcgga 3672421 ggccgggtta ttcgtatggt tccttcataa tcgatggaag aatgttagac aatcgagctg 3672481 aacaatcagt tttgggataa agtggtgaat ttctcatttc ttcggcgctg gctttcatct 3672541 cccagtcgcc gactcatatc cccctaaaaa tgaaaaaccc cgagtcttgt ttcggctcgg 3672601 gattttccat gtcctatttc tgtatcacca gtttactcaa tgtttacgaa aaatatctca 3672661 aatactttaa aagttcacaa aaaattcata aattaattgt tttctggaag caggctcgtt 3672721 tttaactcat ctgaggaacg gtcccatagg ccctgatcat gctttttcag aaattcgcct 3672781 agtacacgct tcgagctgtc gtccatttta tcaacgatga ttttccgttt catggattta 3672841 tccatcagat tcacatgctc aggcagtgac ttgtagcctc ttctgatgct tctgtcgacc 3672901 gtcatttcac aggctgtcac accagcgtaa taaggcccct cttcttttct gtcaatcgtt 3672961 acccacacaa gccagtatgg ttttccgttc ggcacttctt ctttattcgg gagaaattta 3673021 attccttttt caacggtgct gcgggcatgc atagcgccga tgtctacgaa cgcttctttt 3673081 tcctctacat caacgaatac gggagaaatg ttatcaaggc tgagtgcccc tacgccaaaa 3673141 ccgccgtgtc cgtctgtcgg atcacttttg ataatattaa acccgattga ttttttcttt 3673201 ttttcttcca tgaagttcta cctcctacaa aagcggttga aatatcgctg aaaacagctt 3673261 taaaatcgaa tctcttcctg cattgagcat cggccacagc acgtaagatc ctagcggtgt 3673321 cacaaacagc accaaaaata cgataaagcc gtagctctcc gcctgcgtca ttttggcacg 3673381 cacgcccggc ggaacgagat cttctataat tcgatagcca tcgagcggag gaagcggcag 3673441 cagattaaat aaaaacaaga caagattcag ctgtatccaa atagaaaaaa actgatccag 3673501 ccccgtgctg aacgccgcaa gcatttccat tccgtacgca tgcatcaaca ctaacaaaaa 3673561 gaaaccaata aacgcaagaa tcaggttact gacgggcccg gctatagata cgagcacacc 3673621 agcaagccgg ggtttcttaa agaaacggcg attcacggga atggggcgcg cccacccgaa 3673681 tccggccacc agaatcaaaa tggttccgaa cggatcaagg tgtttaatgg gattcagcgt 3673741 cagtcttcct tgttttttcg ccgtatcgtc accgaatttg tatgcgacat aagcgtgggc 3673801 aagctcgtgc atcgtaaacg acacaattag cgtgatgacg aggtatggca ttaaagataa 3673861 cggataatat aaaaaacggt ccaagtgaga tatccctctt tctcaaaatg caagaattta 3673921 ctttattcag tatactataa gaagcctctt tttctaaaga gaggaaacga gataaaggag 3673981 gattcagcac ccatgccata cgtaactgtc aaaatgctcg aaggccgtac agacgagcaa 3674041 aaacgcaatc ttgtcgagaa agtaacagaa gccgtaaagg aaacaaccgg tgcttctgaa 3674101 gaaaaaattg ttgtctttat agaagaaatg agaaaagacc attatgccgt cgcaggcaaa 3674161 cgcctgagcg atatggaata atctctataa agccggcgct tcgcgcaccg gcttttatta 3674221 tccctattga gccagcttcg caataatcgc caagaacgtc tttttctctt cggctgttaa 3674281 acgttcaaac atgccatcaa tcagctgctg gcggttttcg atcatttgtt cagccgctcc 3674341 ccggcccgat tcagaaagag taatccatac agtgcggcgg tcattgttat ttctggatct 3674401 ctcaataaac ccttcctgct ctaaatgatt cagagctgtg gtcgtggcag agggagacag 3674461 tgtgacctcc ttcaaaatat cctttatggt gcagctccca tgtctgtata tgatccgcag 3674521 aataaaccct cttacattat tcacgtgttt cggaacggtg gcttcatcta attgcttcgt 3674581 gcttttcaaa tactttgtaa gtgcgtgatc cagcaaattt gcttccagtt tgtcatggtc 3674641 catgtcaatt tccccatttc gagatgcatt cataacatac gaacgatatg atttacttat 3674701 tattttactg attccgaata gggaaagtca aaaaagcaaa atgtgaattc acagctttta 3674761 tcctacatgc ctcgattttc cacctgtttc acaagtttat ctttaaaagt ttggaaagga 3674821 acgtgttcat tctgctgatg tccgaatcgg cggacgttta ccgcattctc ctgctcctca 3674881 tgatctccaa gcaccagcac gtacggaatt ttttgcacct gcgattctct gattttatag 3674941 ccgagcttct cattgcgctc atcaatgccg gctcttatcc ccgcctgctt cagctccgcc 3675001 tgcacttttc tgcaatagtc taagtgaacg tgcgaaaccg gtatgatttg aacctggatc 3675061 ggtgcgagcc agactggaaa agccccaccg taatgctcga tcaaaatgcc gaagaaacgg 3675121 tcgattgagc cgaaaaccgc tctgtggatg acaacgggac gaaccttctc attgagttcg 3675181 ttgatatatg ttaaatcaaa tttttccggc atttgaaaat caagctgaat tgtcgcgcat 3675241 tggtggctcc gtttcagggc atcttttata tggaaatcaa ttttcggccc gtaaaacgcc 3675301 ccatcgcctt cattgatctc ataagagagg ccaagctcct caaggacgcg tgctaaggca 3675361 cgttccgacg cttcccaaag gctgtcatcg cctaatgaat cctccgggcg agtcgaaagc 3675421 tcaacagaat actcgaaacc aaatgtccga tatacctcat caatcagccg aatcgcttct 3675481 ttgatctcac tctcaatctg atcctcccga acgaaaatat gggcgtcatc ctgacagaac 3675541 gtccgaacgc gaagcattcc gtttaaagcg ccgctgtatt catggcggtg cacctgtccg 3675601 aattccgcca tgcgaatcgg cagatcccga taagaataca ggctgttttt aaagatgagc 3675661 atgtggccgg ggcaattcat cggcttcatt gcgaatcttg tatcatccac ttctgaaaag 3675721 tacatattgt cgcgataatg gtcccaatgg cctgactgct cccataaccg ctgattcatc 3675781 ataaacggcg tacgcacctc atcgtagccg gcatttgttt gcagctcacg cgagaagcgc 3675841 tccagctcat tgcggacaat ctgccctttc ggcaaataaa acggcatccc cggcgcttct 3675901 tcagaaaaca taaacagccc taactgtttg ccgagcttgc gatggtctcg ttttgccgct 3675961 tcttctagca tatgcaggtg cgcatccaaa tcttttttct tttgaaacgc aaccccgtac 3676021 acccgctgca ggacttcatt tttgctgtct ccgcgccaat aagcgcctga tactcttgtc 3676081 agtttgaacg ccttgatcat ccctgtagaa ggaagatgcg gccctcggca caggtcaacg 3676141 aattcccctt gctggtacag tgtgatatcc tccccgcgcg gaatatcctt taaaatctca 3676201 agcttgagcc gctcgtcttt ttgtgcaaac agctcttcag cttcttcgta agaaacctct 3676261 atacgtttga tttcaaggtt ctcatttatt atgtttttca tttctttttc gatggcctct 3676321 aagtctcctg atgccaagct tttccccagc ttcatgtcat agtagaagcc gtctaaaatc 3676381 acaggcccta cccccaatga cacttcgccg tacagccgtt ttactgcttg ggccagcacg 3676441 tgcgctgttg tgtggcgaag cacctgcaag ccttcttgtg aatcgagtgt gacaatcgaa 3676501 agctcagcat cctcctccag cttgaaactg agatcaacaa gcttgccgtt gacctgacct 3676561 gcggccgcct tcttttgcag actggaactg atcgaaccag ccgcttcttt gattgtgatg 3676621 cctttcggat attcctggat ctgtccgtcc ggaagctgaa tgtgtacatg tttgctcatt 3676681 ttagaacact ccttattcat tgttgtatat aaaaaaacac acccgtcccg cagataggga 3676741 cgagtgtgtg attaacccgt ggttccaccc aagttcccga caaatactat gttgtcggct 3676801 cggtgctgta acgcagcata gacggcattg gttacttcag ttccccaatg ctgctccaag 3676861 gcggtaaatg atattcctaa gctgggaagc tctcaccttt ccttccctct ctgaaaaccg 3676921 taactatcat tcatgtcctt ttcatcgcat gtattcaatt cataaaaaaa cacacccgtc 3676981 ccacagatag ggacgagtgt gtgattaacc cgtggttcca cccaagttcc cgacaaatac 3677041 tatgttgtcg gctcggtgct gtaacgcagc atagacggca ttggttactt cagttcccca 3677101 atgctgctcc aaggcggtaa atgatattcc taagctggga agctctcacc tttccttccc 3677161 tctctgaaaa ccgtaactat cattcatgtc cttttcttcg catgtattca attcaaataa 3677221 aaaaacacac ccatccctct aaaagggacg aatgtgttga tcatccgtgg ttccacccaa 3677281 attcccgatc aattacacat gatgatcggc ttaaagatgc tgtaacgcag catgacggta 3677341 tcagatactt gttttccctg atacggctca aaggcggtaa gctgctttcc ctgcgttagg 3677401 aagatctcag ctgtccttcc ctctctggaa accgtaaaaa gcatctcgtg tccttatcag 3677461 tgcctgttgt ttcaataatt ttttatatct tactatatat tcccacaaag cgcaatcagt 3677521 gatttacatt ttttctgacg cggcagtccc gttatgggca gccagaaaca gccatacaag 3677581 caatgcagcg aggctgtatg ccgctcccat catcaaaaac gcaaacccgg caccagcata 3677641 ccaagtggcg gacagatgaa tgatcacccc ggttatcgct acgccgacca aggctccgat 3677701 ttgccggttt gcatttaacg ccgcaccggc gatattcgta tgtctttgcc cggcagcctg 3677761 catgatcaca gttgtcatgg caggaactgt aataccggta cagaggttca taacagacat 3677821 caacaccgcc agctgccaat aaggaaaatc cggagaaatc agcacaaaca acagcaatgc 3677881 aatgatacag ctgaccgcca ttgatacaaa cataagctga ccggcttcaa accgattcgc 3677941 cagacgggca aacagcagat tgccgatcac gaagaccgcc atcatcggca gcagctccac 3678001 tccagccata aaggaacttg cccctcctgc ttcctgcaaa aaaaggctga gcataaacat 3678061 gccgccaaaa agggcgaaat tcagcaaaaa cccgataaat tgggcagctg agaagcggcc 3678121 gtttttgtat aaggacgccg gcaggatggg tgtttttgca gaaatttccc gcagcaaaaa 3678181 cagcacaaat gccaaaaccg ctgcagtaaa tgctacaaga atcactggcg agcgccagcc 3678241 cgctgaaggc ccctgtatca aagcatagga aagaaacccg agagccatca tgccaagcag 3678301 atgcccgatg atgttcacgc ggctgctttt cccaggaacg cggctgagga ttcggtaagc 3678361 tgaaatgagc gcagcagccc ctattggcac attgatcaga aaaatactct gccagcccgc 3678421 caactgtacc agcacgcccc cgataaaagg cccaagggct gaagcggcgg aaacaagcgc 3678481 ggcccacagt ccaaacattc tcgcccgcgc ccgctcatca aggtaagagg cagccaaaag 3678541 gctgagtgag cttggcataa acaaagctgc cccaattccc tgtatgagac gtccggcaat 3678601 cagcatctgc ccatttatag atgcagcgca tagacaggag gccataacaa aaacggctag 3678661 acccaagata tagatcgtct tcgagccgaa acggtcagcc aaggctccgc ccgccagcag 3678721 aagcgacgca aaagtaagaa tgtacccgtc cacaacccac gttacacctg aaagtgacat 3678781 tgaaagagtg tttttcatat cagccatcgc cacattcaca acggtcacat caagagttgc 3678841 catgaggaaa ccaagtgcga gcacgatcag cacggatatg cctgttgatg atgttgattc 3678901 ttgtatagac ccgctatttt tcattacaat tgccctttca cttgcttgat tacccaatca 3678961 tctatttttt caagatcata caattccccg actctgtcca taacatgctg caaggattct 3679021 tctctcataa gattggacca tttatcctcg atttccgcca tgactgtctc cagcacacag 3679081 tgactttcac cctcaaatac agattgcagc aagcctttcc cctgatacat cgaacctctg 3679141 ccttcgaccg cttgataaac atcataaagc gtaatgtcag ccaaaggctt cgtcagggta 3679201 aaaccgccct tcgtccctgg taaggattct gccaaaccgg cttgaaccaa tgttctcatc 3679261 agcttcttca agtaagacgg agacacgcgc aatcgctggc ttatagcctc tgacgtcaaa 3679321 gaagcctgta ccggcagccg tgacagtaac agcagcacag aaaccgcctg ctccattcct 3679381 gatttcattt tcatcctatt cactcctgat tcattatgga taactattat ccataatgaa 3679441 tctcttagca gcttttgtca ataaaaaaag caaaagaaac ggatcatttc ttttgcttgg 3679501 tatggttaac aaatctgctt cagttcctct atgtattgaa gcgcttcgtc atattcttca 3679561 tttgtatatt tttgcttgct tttgatggta aagacttttt ctttcttttc ctcatcctca 3679621 agcccgtcaa agtaaaggat cgtggaaacc agctctaaaa accgtgatga acggctgttt 3679681 acactgtcga tatagccttt catatccggc atgtccagat cagcatggtc taaaaatgcg 3679741 gagcctgtct cagtcagcga ataccggtat tgaaagtagc cgcccttttt ttccttcacc 3679801 tcatgcagaa atccaaggtt gcacagctct tcaatctgga gcgtcagttc ctctgaatat 3679861 ggtccgtaaa agtgaaaatc atatttctca tagaaaggaa actgcatttt cttggcgata 3679921 taaatcattt tctgcagctt ctttcgcccg atgatttctc cagaatccga gaacaccttc 3679981 atcagttttg catgttcttt caacaaattc ccgacatctc ctttttcctt ctttccaatt 3680041 tctatgtcag tcccagcagc tgccggattt tcattttcgc ttccggatgt ttagtgccgt 3680101 cacaaatcaa gtcctttgga tagtacagct tgtggtccgt ccgccgttta cctgagatgg 3680161 attccacaat agccgactgt ctggacagct ctttaatttg gccgttttgc gtcaagagat 3680221 ggatcggcag acgctcctct tcctctcctg gtcggtaaaa atcgtatggc agatctgatg 3680281 aagaatcaac gaccaaataa tagctcggat cgatccccgc ctctttgaac aatgaagtca 3680341 gctcaaaata agccgacatt tcttcattcg gattgaattc aacgtattgg aaaagctggc 3680401 ggttaatgaa tctgcggcac aagtcggata aaatcgcgtc ttcttcatcc tcccaggcct 3680461 ggaagtaata caaaataata gattcatcca gctttacata atcctccagt gtcaattttc 3680521 cttcaaaaat agaatagaaa tgaaccggag cgtgagtgaa gacatagcct tcatcgtgca 3680581 gctgcttcgc cctgtgaaga atcttcgtta aaatgacctc tgcacttcta gtcacaggat 3680641 ggaagtagac ctgccagtac atttggtaac ggctcatgat atagtcttcg acagcgtgca 3680701 ttccgctttc tttaatgacg atctgatcct cgcgcggccg catcacccga agaatccgct 3680761 ccatatcaaa atggccgtag ctgacgcccg tataatatgc gtcgcgctgg aggtaatcca 3680821 tgcggtctgc gtcaatctga ctcgaaatca ggctgaccac ttgcttgttt ttatatgttt 3680881 tggcaatgac ttcagcaaca tcctgaggga aacccgggct cacctttctg agcacctgat 3680941 taacctccgt gtctcccaaa atgatacctc ttgtaaaatc ctcgtggtca aggtgaaaga 3681001 ccttttcaaa tgaatgcgag aacggcccgt gcccgaggtc atgaagcagc gccgcggcca 3681061 aacagagttc gcgctcactg tcatcccatt cagggcggcc tttaaagacg tcatcaacca 3681121 ttcttctgac aatttcatag acaccgagag aatggttgaa ccggctgtgc tcagccccat 3681181 ggaacgtcaa ataggtcgtt ccgagctgct taattctgcg gagacgctga aattcacggg 3681241 ttccgatcaa atcccatatc agcttgtccc gaacatgaac atagcggtgc accggatctt 3681301 taaacacttt ttcttctgat aattttccat ttggatacgc catcgtcatt ccctcttttt 3681361 tttagccgtg tttctattat atcgactcta ttctttgaaa acatccttga atttgcccgg 3681421 cgatttgttc catcttcatg aaaaacacat cttgtgaagc aaaaaagcct gacctgaggg 3681481 ccgaggctaa gaaaaaatat gtttttactt ttttattttc ttttttactt tgtcaatcag 3681541 ctcatcctct gtcggagctg acagcgggcg attgttcaca aaagcaaatg attttttccg 3681601 tccgggcccg caataagatt ggcatcctac ctcaaccttt gcgtccgggt ccacttcttt 3681661 caaacgcggc agcaatgttt tgatattagt ggcttggcaa tcatcacaca ctcgaaattc 3681721 attagccatg acgtacgctt cccttcattt ctatgttcat ctatgtgaat aacctaaaat 3681781 cacgtttcaa aaaaaatcac atcacacttc attttacaag gattcgactg ttcctgcaag 3681841 ccgctccatc cttcgtatct cctattcttt cagccaattt gtataaatat tttccaacct 3681901 ggacattcta ataccatgaa aagaaaaatg ggagttgaga taaatgacaa aacagcgaca 3681961 agacgcttgg tcagaggaaa acgatctgct tttagccgaa acagtgcttc ggcatgtgag 3682021 ggagggcagc actcagctga acgcctttga agaagtcggc gataaattaa accggacatc 3682081 cgcagcctgc ggattcagat ggaacgcagt ggtccgccat caatatgaaa aagcgcttca 3682141 gcttgcgaag aaacaacgaa aacagcggat gagagcgctc ggaaacgggc agcccgcgaa 3682201 aaaaagatta ttatatcagc ctcctgccgt tgatcctgaa atcattcaag aaaccgctgc 3682261 agaagagccg gttaaaacgg aaacaccatc tgtcgaaaat gagcaacctt taatgtctgg 3682321 cgaacacatg ccttttgttg atgaaagctt taaggaagag ttagctagtc tatcacactt 3682381 attgtctcct caaacgcctg cagctgcgcc tgagatgacg atgaatgatg tgatccgctt 3682441 cctgcagaat tacgaaggca atcacgagca atcatcagca ttaaaaatgg aaaacgagcg 3682501 tttaaagaaa gaaaatcagg aattgcaaaa caaaacagag cagctagagg cagaagttca 3682561 aaagcttgaa aaagaccaaa aaacgatcca agaagattat gaaaccttgg tgaaaattat 3682621 gaacagagcc agaaagctag ttttatttga agaagatgaa catgcctctc cgtccttcaa 3682681 aatggaccgg aacggcaatt tagaaaaatt agcggaatga catagaaaaa tcccaaaacg 3682741 ggcagctgtt ttgggatttt cgccatgtgc aaaatcccct tttctattga gaaaagagaa 3682801 tttcctcatt ttgcagccgg atcagctatt cttgtaaaat gaggccaagc ttatgtgaat 3682861 ctattaagac atgtgagctg cctcggccgt tttttgtttc cgaggcgcag cagaaatgac 3682921 caaaagcccc agcatcataa gcgcaatgcc cagccacgag gaaggcgaaa gcatttcccc 3682981 tatgaaaaac acgccaagca atgaagccgt cagcggttca gctaaagaca gcgtgaccgc 3683041 cgccgaggcc ggaaccccgg taagcccttt cgcaaacaaa aagtatgcgg cacatgttgc 3683101 aattaacccg atgtaaaggc ttgttcccag tcctctaggg gtcaatatcc acgagatatc 3683161 taactgccat aatagcggcg tcagcaagat ggcgctgatc atgaatacaa cggcggaggt 3683221 cgctcgcgga ggctgggttt tcatcatcgc tttactgatg agcgtatagc ctgcaaaaga 3683281 agcacccgct ccaagcgcca taagaacacc agccacatca atccgaacat tggaactgtc 3683341 ggaaaacaga agccagcaac ccgctaaagc cagcacagtc gcaatccacc aggagtttcg 3683401 cgggcgtttc ttcaatacag cccattcgag ggtcccggca atgataggcg cactgccgat 3683461 ggcaatcaca gttcccactg caattcccgt ttctttaacc gctgtgaaaa acagcggctg 3683521 gtaacacgcc atacaaacag cggctaaaaa tacgagcggc catgcccaat ttttcacgtg 3683581 aagctcccgg ctgatccaaa ccgcaagcag catggcgctt cctcctatta ataacctgaa 3683641 cgctccaaat gccagcggtg tggcgctttc tggagccaat gcctgaacgg ttcccgtggt 3683701 cccccagaaa aaagccgcaa tcaatacaaa aaggctgtaa atattcccct tcatctgcct 3683761 ctccccttta atatggatgc tgatgtcatt ttatcgtttt tctttttgtc gtggttatct 3683821 gtatgtaaga aggacttatc tgaaaataag attattgagg taaaatgccg cttgagataa 3683881 aaaatgcatg ccggcatata cagccggcat gcgaagaacg ttcacccaaa tacctttgca 3683941 ttccgctcag ccatccggac gaggtttttc tcaaattcca tttcctcatc aatggacagt 3684001 ccagctgaat aaagatgggt gcttaacgct tttaattccg tcaataaagc gaacattaag 3684061 tcttgtacgg agatgtcttt ttgaagaagc tcacttaagg acgccatcgt ttccggacgt 3684121 atttccggat agacgccttt tttatcgttt tgtttgtctt tcagcgccgc ttgatagaat 3684181 cgtctgatca agtcggccct ttcactgccg cttttatctg cacagagata aatttgaaca 3684241 gcgactccgc cgcgaacgcg tctctgagag atgccggcga actttttgcc atttatactg 3684301 aggtcatagc tgccgggaca ataagaccct tcaatttcat aggcttcgat ctttgcgttg 3684361 tacggtctca gcattcgtct catcagctcg accatcgctt catatccttt gtctatatcg 3684421 atgcctttct tttcgtcctc gaatatgaga gagatattta aaacaccgtc atccaatacg 3684481 acggcaagac cgccggaatt gcgtacgatc acacggtatc cttcgctctc cagcaaggag 3684541 ataccatcct gcaaaaacgg gaggcgtgta tcctgtattc caaggacaat tgtatcgtgg 3684601 tgcacccatg agcgcgctgt cgccggcgac acgccttttc cgacggacat gcatagcgta 3684661 tcatccattg cgaaggattg cttcgcatca aataaagggc cgagactgga ttggtcaatg 3684721 actctccatt tcggctgcat cagtaaatca atcggttggt ttgccatcta tgtaaaaccc 3684781 tttcatgtta ggcttattga acgaaaacta ttatatcatt tcagcagctg tgattgataa 3684841 ttgcttttca gcatcgtaat aaaaatttct ttattttttg tattctccat gagaggagaa 3684901 tgaatgtaag acagcttgcg ctttaacgag aaattattaa tatgcagaat tgaaatttcg 3684961 cggtggatca aatccttacg cagcacgctt ctggatagaa ccgaaagtcc catgccgtta 3685021 atcaccgctt cctttacacc ttgattgctg ctgatggtaa acattgattt cggccgaagt 3685081 ccatttgaac tgagtacatg atcgagatat tctctcgtcc cggagccttt ctctcttgtc 3685141 acccacgctt cgttctgcaa atcgctgatc gaaatctctt tccgcccggc gagcggatgc 3685201 tgatttggag cggcaatgca catttcatcc tccatgaacg gttcaatttc cagctcattc 3685261 tcgtttgtat gtccttcaat cagcccgata tcagcctgaa gcatccgcac acgctcgctg 3685321 acctcctctg tattgccaat catgacatct agattcagct ctggatacag cttttgcagc 3685381 tgggccaata gcggcggaag aatatactca ccgattgtaa agcttgcagc tattttcaat 3685441 tcacccttca catagtgatg atgcgcatag atttcagcct tggcttgttc gtagagaaac 3685501 accatttgct ttgctctttg atataaaatg tctcctgtcg gcgttgtcgt aaagtgtttt 3685561 ggcgacctgt tcagaagagc cgtttgaaat tctttctcaa gatttttgat atgcagactg 3685621 acgctgggct gggagatcat cagcttttcc gccgcttttg tgaagttttt ttcttctacc 3685681 accgctataa acgttttcag cacgtcgtaa tacaaaaacc ccacccctgt cattaatgaa 3685741 atatatggtt atgattagtt ttctttattg tactcatatc atccgtcttg gtaaagaagg 3685801 gctatacaga agcgcaaaaa aggcagccct cggtcgagag ctgccattgt cttcaatttt 3685861 attacagtgc ttgcgccgct gtaattaatg cgagattgta aacatcttca gcgttacatc 3685921 ctcttgaaag gtcgtttaca ggcatattta aaccttgcag gattggtcct accgcttcaa 3685981 agttgcccaa acgctgagcg attttatagc cgatgtttcc tgcttcaaga cttgggaata 3686041 cgaatacgtt agcgtcccct ttgatctcgg aatccggcgc ttttttctca gctacagatg 3686101 gaacaaatgc agcatcaaat tggaattcgc cgtcaagtgt cagttcaggc gctttttctt 3686161 tcgcgatttt cactgcatcc gctacttttt ctgtttcatc agattttgct gagccttttg 3686221 tagagaagct gagcattgcc acgcgaggct caatgtcgaa catttttgcc gtattggcac 3686281 tttcgatcgc aatctcggca agatcttggc tgtcaggtgc aatgttgatc gcgcaatctg 3686341 cgaatacgta ttgctcttct ccgcgagcca tgatgaacac gcctgaagtc tttttcacgc 3686401 cttcttttgt tttgatgatt tgaagagccg ggcggacagt gtcagcagtt gagtgagcag 3686461 ctccgcttac aagtccgtct gcaagtcctt tatacaccag cattgtaccg aagtagttct 3686521 cgtctaataa tgctttacga gcctgttctt cagtcgcttt gcctttgcgg cgttctacga 3686581 atgcttgtac aaggtcttcc atgccttcat atgtatgagg atcataaatc ttaacgccgc 3686641 ccagcgtaag gttcaattct tttgcttttg cttggatctc attttcattg ccgatcacaa 3686701 tcggattcag cactttgttt cctgcaagct tgctgaccgc ttctaaaata cgctcgtcta 3686761 agccttcagg aaatacaatt ttaacgtctt ttccagctac tttttcttgc actgttgaaa 3686821 ataaatctgc cacaataaaa cctcctcaaa aagttacaaa aacgctttct tttactagca 3686881 tactcttctt ccaatcaaat tcaaacagcc aactttcatt atagcgcttt cataaaaaaa 3686941 tcttattttt ctaactaatt taagtgactc aatcttccct tataggttct tctattttga 3687001 tggagttata cggaagggat gttcaaggtt tctccacagt agaatcggat aaactatggt 3687061 atagtgaagg caatcatgaa aagataatgg gagtgaagat aaatgagtga acagcaaatg 3687121 acgaatgaag cggcaaaaac gcttgacggc tggtatgcgc ttcatgattt ccgcacaatg 3687181 gattgggctt cctggaagct tctgtccagt gatgagcgcc aatctatcat acatgaattc 3687241 accgggttgc ttgaaaaatg gggcgtagcc caaaaagaag gaaaaggatc gcaaactctt 3687301 tacagcatcg tcggccaaaa agctgatttt atgctgatga tccttcgtcc tacaatggaa 3687361 gaattaaatc aaattgagct tgaattcaac aaatcaagac ttgctgagtt caccattccg 3687421 gcatactcct acgtatcagt ggtagagctg agcaactact tggcaagcgg tgacggcgat 3687481 ccttatgaaa atccgcatgt gcgcgctcgc ctttaccctg aactgccgga atctaaatat 3687541 gtatgcttct atccaatgga taaaagaaga tctggcaacg acaactggta tatgctttca 3687601 atggaagaac gcagaaactt gatgagaagc cacggtttaa tcggccgcag ctatgcgggc 3687661 aaagtcaaac agatcatcac cggctctgtc ggctttgacg attacgagtg gggcgttaca 3687721 ttatttagcg atgatgtcct tcaattcaag aagctagtgt acgaaatgcg ttttgacgaa 3687781 gtcagcgctc gctatggcga atttggttca ttctttgtcg gcaatcacct ttcgcttgat 3687841 acacttcctc aattcttata tgtataatat cccctcccgc cctatccggc gggagttttt 3687901 caattctcct ttatcagaat ttaaataaaa tttgctattt tcttcgtttt ttcttacgat 3687961 gtagataata atccattttt ttcaaagggg tgcagttatt tgtcaaaacg aaccgcattt 3688021 gttatgggag ccagtcaagg gatcgggaaa gcaatcgctc tgaaattagc agaccagcac 3688081 ttttccctcg tcattaattc gcgaaatttg gataatattg aatctgtcaa agaagacatt 3688141 ttggccaagc atcctgaggc gagcgtcatt gtccttgcgg gcgatatgtc tgaccagcat 3688201 acgagagcgg gcatttttca gaaaatcgaa tctcaatgcg gacggcttga tgttctgatt 3688261 aataatatcc cgggcggcgc gcctgacaca tttgataact gcaatataga ggatatgacg 3688321 gccacgttca ctcaaaagac cgttgcctat attgacgcaa tcaagcgtgc ttcctcactg 3688381 atgaaacaaa acgagtttgg cagaatcatc aacattgtcg gaaatctgtg gaaagaaccc 3688441 ggcgccaaca tgttcacaaa cagtatgatg aatgccgctt taattaacgc cagtaaaaat 3688501 atttccatcc agcttgctcc tcacaacatt actgtcaact gtctgaatcc tggttttatc 3688561 gctacagacc gttatcatca atttgtggaa aatgtgatga aaaagaacag catatccaaa 3688621 cagaaagcag aagaacagat tgcttccggg attccgatga aacgggtcgg atcagccgaa 3688681 gaaaccgcag cgctcgccgc atttcttgcc tctgaggaag cctcctacat cacgggacag 3688741 caaatttccg ctgacggcgg cagcatgaaa agcatataaa aacatcccgc tttttagcgg 3688801 gatgtttctt gtaatgaccc gaacggcagg ttcagctttt gaatccgcgt gacaaattcc 3688861 cgcagatcct cctgcttcga caccattgag attctgacat gcctttttcc gttgcttcca 3688921 aaaatttcgc ccggtgtgac tacgacatgg gcatgctcca gcaagtaatc ggaaaattgg 3688981 tgagatgtct caaacgtatt cggaatttca gcccatacgt aaaaggttcc ttttggcttt 3689041 tccatcttcc agcccagttc cttttcacaa agcgccgtaa aaaagtcaat tcgttcctta 3689101 taaattcgtt tcaacgattc cgtatgctcc ggatctccag aaagcgccgc actcgctgcc 3689161 tgctgcagcc cgccgaacat gccgacaaat acatgatcct gaaattcatt gacggcctga 3689221 atgatttttt cgttcccaac cgcaaacgcc attctccagc cggccatgtt aaatgttttt 3689281 gaaaatgaat aaagctctgc tccgacagtt ttggcatcct ctgcctcaag aaagctggcc 3689341 ggtttttgat cgaattcaaa cgccccgtat gcaaaatcat gaatcaaatg gatgttatgc 3689401 tctttcgcaa aagcagcagc ttttgcataa aaagccgcat cagccacagc tccagtgggg 3689461 ttgttcggat agtttaaaaa cataagcttc gctttttcca gcacggctgg atcaatcttt 3689521 tcaaaatccg gcagatagcc attttcttca tacagcggca tttcgtaaag ctcagctcgc 3689581 gccatcgtaa tccctgataa atattcagga tagcctggat tcgggactaa agcgatgtct 3689641 cccggattga gcaggcattg tgtcagcaca tacaatccgg ctttcccgcc tccgaaaagc 3689701 gcgacttccg tttcaggatt gattgtcact ccgtattccc ttttatagaa agcggcgatc 3689761 gcttccttta aaaaaggata gcccctgaaa gggccgtatc catgaaacga aggattcaga 3689821 gaagcctccc gcaaagcctc gacaatatgc ggcggagtgg gaaggtcagg gttcccctgt 3689881 ccgagattaa tgatatgggc tcccgttttt tccatttcct ttaccttttg aaaaacgaga 3689941 gaaaactcct gccttggaag tgtcttgatg acatcggacg gtgttatttc catctaaaag 3690001 actccttttt gctccgtttt gttatcccgt tccaaaaacg atttgttgac gagcttcgta 3690061 tgcaaaaaca aaccgcatac gatcacgaca atcagcccca taatgaccgg agcgcttagg 3690121 atgttaatga acattgaacc aatagaaatg cataatccga tagacgcttc ggccactgaa 3690181 aaaatgcgcc cttgaatctg gtttgccgca ttttcctgaa ccttcacttt tgcaagcact 3690241 tccccgtatt ccatcgcgat gaaaaagagg atcgccgcga tgacagaaac agcgaatatc 3690301 ggtgtgaata aaaacagcgc cagcgagaca atggataaaa cggtaaagta cgtcaggcct 3690361 ctattgttgt taaagcccca tttgctgaca agcgccgctc cgataaagcc gccgaagccg 3690421 atgcagaacg tgagaataaa gttgccgatt tccccgtcac ccagaaagcg gctgacaatc 3690481 ggaaaatagc tgtacacaac tccccacagc aaagccattg taatcatcgt aaacatggcg 3690541 tttaatacga atgaattggt tttgatttcc ttgagtcctt ccttaaaaga ctgaaaggcc 3690601 tctttaatgt tttcagattg aatcggcaca aattgcagct tgatgcggct gataaaaaat 3690661 gccgaaacca agtatgtcac accgttaaag gcaacagcca gctctacaga tccgcctaac 3690721 agaaagagcc ctccggcagc cgccccgacg ataatggaga tggttgtcgc ttttgcaaat 3690781 aacgtgttga tgcttttaat atctgattcc aaggacgaca tgacagcgag acgggcggga 3690841 ttaaaaaaca cgccgcttcc ataagtaata aacagcaggg ccagaaaaat cagcggatac 3690901 tcgccttttg gaagaaatgt gagccccaaa aagatgatgc ctctgatgat atccgtccac 3690961 agcatgatct taattctgtc taaccggtcg accagaacac ccaaaaacgg ctgaaacacc 3691021 atcggaatgc ttctgaccac gatgaccccg gacgtcaccc aataatcgtg ataatatgta 3691081 gacaaaatga gcagggcagg gagaacacaa tagtctccca tgaacgatag cgcctgcccg 3691141 taaagcaagt atttagagtt gggtttcagc tgtttcatac tggcagcaca tactttgccg 3691201 tcagcttcgc atgctgctga atttgtctga ttgattcagc cacatcctgt gaattactgc 3691261 ctttcagttc aaatgcagca atggaattga aagcttcaaa caatgtcaaa tcaactgaag 3691321 tgcctggtgc tgcggccgaa aaagaaacga tttcagtatc cccttttaaa agcccgtccg 3691381 gaatatcgat cgcttcaatg accaaatcct cagcagtttc aggaatttgg ccattttgtt 3691441 tgaaatgctg cgggtacaaa tggcagtcgg caacataata aggctcttga tccaataatc 3691501 cgtccggcag atcggcgtct tttccgaaac agaggacatc taataataat tgcgccatat 3691561 caaggccaaa gaccttttta atattgggga tcatattcca gccggcaaat ctggctgccg 3691621 actctattaa acccggttct ctgtttttca ttagcttgat ctctgtatgt gttgcgcaat 3691681 tttgcagtcc aagcccttca tttgcctttt tggcagcttc gacaattttc ttttttgcct 3691741 cttcatccag aatggacggc gtaatgtggg atgtctctgt aaacccgatt tgcggcgttt 3691801 tatcatgaat ggcgatcggg aaatactcac cgtcagccat gatgccttct atactgatat 3691861 agtcggagta cccttctgtt tgataccagt ctccgtactc accctgtaaa aattcttcag 3691921 cgataaacgg cgcttcaaac gtaaccgcct ttggcacgtt aattgatttc agatagtcat 3691981 tgactctgtt aaattcatct tctgccgtct cagtgtccgt aatcagcgtt acaccgatag 3692041 aactcgctaa gtatgtaggc tttaagataa gaggtgtgcc gatctcttca agagcagcac 3692101 ggaaatcttc aagagttgtg actcgtttgt ttttgatcga tttgactccg gccttattaa 3692161 aagcgtccct cattttattt ttatctctgg cattttcggc tgcctgcacg ccggcacctc 3692221 tcaagcccag acgttcacag gctttcgcca tcggagcaat gaataattca ttgtttgttg 3692281 tgatggcatc cgccccaaac atttcggcaa ccttgacgat ttgctcgacg acctcttcct 3692341 caggcttgtt atgatcttca tgcgcccaat aaatggaatc agggtgttca aaatcagcta 3692401 aactcttaaa atagtcttta tcttttatga ccgcgaccga gtatttttca atcaatgctg 3692461 catgggaggc tgtaattgca aaaggtcttg gaataaagct gaccaggtta tatttttcag 3692521 cagcgctttt ataaaacatg tgcggcgggc agcctccaag atcagcgatg accaatactg 3692581 tttttctctc catatgtaaa acactccttc tctattgtgc ggtgtatcct ccgtctgcgg 3692641 tgatggcgct tccggtcata tagcttgata aatccgaggc taaaaacagc atcacatttg 3692701 cgatttcttc aggtttccca agcctcagca gcggatttac cttcgctttt tcttttttaa 3692761 tctcttcaag tgtgccttca ttattttcaa ggaatgattt ttcattcagc ggtgtgtcga 3692821 tgatccccgg gcatacgcag ttcacccgaa tttgatgttt cgcataatca acggccattg 3692881 atttagtcag ctgcaaaacc ccgcctttgc tggcgttata agcaggaata tcaggccatg 3692941 ccacgagtcc gccgacagag cacgtattaa tgatgttgcc cttgccggcg gccagcatat 3693001 gcttgagtgc atgtttgctc attaaaaaca tgccggtcaa attgacttgc agcaccttgt 3693061 tccaatcgct gagctccatc tcgtgaatag gcgccacgat ttcgatgcct gcattattaa 3693121 tcaagacatc gagcccgcca aatgtatgaa ccgccgattc aactgcgtgc tggcaggcag 3693181 cttcgtctgt gatgtccgtt tgcacaaagt gcagcctgtc attattttct tttcgtacca 3693241 ttgcttctcc ttgcgcttca tcaatatccg ccacaaccac attggcctgc tggcccaaaa 3693301 aagcctgaac cgcagcataa ccaatgcctg atgcgcctcc tgtgatgagg acggttttat 3693361 cggtgaggtt catgatcatt catccgcctt catttttttt gcttttgccc tgttatagcg 3693421 cggcgggaag aagatattaa tcgattttga ttctttttct gaacggttga tggcaccatg 3693481 atcttcgcga ggctcacaga aataggctgt gccgaatttc atctcgactg tgcagccttc 3693541 gaccgtcatg tcatagccgc cgccgatgca gatgcctatt tgttcattcc gatgtttatg 3693601 gaaaggcatt tctccgccat ttccagggat tttggcaagc ataatttcta cccaatcctc 3693661 aacaaagaac gtgacttcca tgcccggcag caggtctctt gttttgaaaa tatccaaaaa 3693721 gtagtcctca ggacttgtat atgtttcatc agctttcagc cgcttgatat caatagcaat 3693781 cacttcttgg tctgtgtcgt ttcttgcccc gtgaggcaca tgcggcggcg cgatataggc 3693841 agattccaag gctgtcattt ttcttgtcac atctccgaca gtcatcatca gctcgccaga 3693901 aacgaccatg ccgatttgga cctccttatg ctgatggggt tcaacattgg tatgcggcgg 3693961 gacgtaagac attaatactt cagtatcccc tcgtacggtt gaatactgcc tcactccgtt 3694021 ttcccattca attaatttcg gtgtcgggaa ataaagctcc tgcatatctt ctttagtttt 3694081 catcatcaac gtctcctttt ccaaataatg accagctcat tggaatgctt ttgaatgttt 3694141 ttacaaaggt tagcccgtac ttttgccgtg caagctcatt ggttaaggca atgtcataca 3694201 aaccttcttt tacttttctt gcggcttgac tggttgaatt gactagtttg aaacgaacat 3694261 ctttgcgggt aaaatatttt attaaattaa taggtgaagg atgtgaaaca ataacagatg 3694321 tatcaagcat atcgtctctg aattcaaaat caggacgaac agccaggccg tacatcggtg 3694381 tatcgcacct gaagatctgc aatagctgca aatccggcct catgtagaaa tgcttaatgc 3694441 catcgtaagc atgtgggacg atggtatatt ccagcgggct ttggagcgtc ctttcgatgc 3694501 acgattcaaa agtatcatgc aaggacaatt tactgttcag cccttgtaga agagtaaaat 3694561 tggaaatgaa atgctttgct gcgtactcac tgcttgtccc ctcagggccg agcgtgttga 3694621 ctgtaatgag tttggatagt gaatcagttc ttttttttgt ctgaatgcta ttatccaata 3694681 taatcatgag caccaaccaa tcttttaaaa ttttaagtaa attttatcca gtggaaattg 3694741 aactgtcaat gttttttgaa aatattgata attattccca tacaaacaaa aaaacccttt 3694801 aaaaagggtt tttaattata ggaatttaga aactttgttt attgagataa ggactgatcg 3694861 gccttctgct caagtttgcc gtacttttta tatgcgaata cactgagcac aaatccgagg 3694921 actgtgatgg cggcgcaaat caatccgaca gctgcatagc cgtatgccac atatacgggt 3694981 cccattaaag cagaacctaa tgtcacggcc agattcgagg cgagactgta aaacaccatg 3695041 acttttcctc gatgacgctc tgagcagtca ctcaaaatgg tgctgagcag cgtcaccgtc 3695101 aaactttgca ttaatcccca aataaatagg ctggcgatta acagaaacat agacgccggc 3695161 gcatatggta aacacgccag cagaacgctg atgaccccca gcgcaatcaa aagggagcgc 3695221 atttttccga tgcggtcggc tatctttcct gtaatcacac tcatggaaaa cccgattcca 3695281 taaatcatga taaataagcc cgcagccgtg tttcctccgg taaaaacgtc ctgaagatag 3695341 gtgcctaaaa aggaatacat accgtaaaaa ccaatcatat tacaaaaggt tattgtgata 3695401 taaacaggta cacgagggac tttcagcgca tcccggaatg ttcctgcggg ctcttctatt 3695461 tcttccttgc cgctgttttt atgttgggca tggcggcgca tttcaaggag aatcagcaga 3695521 acaactaaaa cacccatcag ggcgaaaatc caaaacgtcc atctccaatg caggacgccg 3695581 ccgataaatg atccgagcgg cactccgaaa atcagcgcca gcgaccagct tgaaacgatc 3695641 agtcccatca ccttgccccg gtatgtataa ggaacacgat caccgacaac tgcgtaagcg 3695701 gtcggaacaa acgctcccgc agccaatccc gaaagcgccc ggcctaaaaa gaagaaaaaa 3695761 atattttgag ctaaagcgca tatcaccgtt cctatgataa aaatcataag cccggccaat 3695821 aagctcagtt ctctggagta tttatcgcct aatggaacca aaagcggcgc accgataaaa 3695881 atcataacgc cgtaaatact gatagataac gcaaggacgc tgacatctga gctgaaggct 3695941 tttgctaaat ccggcagcag cggtgagatc acaagctctt cagatccggc tgcaaatacc 3696001 cccatcgtta aagccagtgc caacaataac ggaaaatgat gttttgtttt gatgtcattg 3696061 ttttgattgc tgttcattct ttctcaaaca cctcttccat aatcttctta tcataaagtt 3696121 gtattatagt ttagcattgt tttttctcta tttacaattc gaacgaaata tttataagtt 3696181 ttattatttt catttaaatc ccattatata tttctatatt tcattctaaa aatacatgag 3696241 gatgtaacac gtaaaaaaag ctctccggcc tcccggagag ctttttctat tgcgcctctg 3696301 tctgcttttt ttcaatcgtt tcatgattta tacgcttttt gatgcttaga tgatagtatg 3696361 cataacagaa aataatgatc ggcacaccgc agtataagcc aattctttga tccggaatga 3696421 aaataaggct gatcaacacg cagccatata aacaaaatcc gagaatcggg actagcggat 3696481 aaagcggcgt tctgaactcc agatcattca catttccgcc ttctgccagg aaacgcctgc 3696541 gaaagaaaaa ttgcgacgca caaatggaca tccacgcgac aactgtcacc atgcccgaga 3696601 ttgagataca ccataaatac actgtttctg cagccatgac acttgtcagc agcgaacagc 3696661 ctgaaatgcc tagcgtaatc agcagggcat tcatcggcac gccttttttt gtcagtctgg 3696721 tgagaaagga gggacccatt tgatttgatg aaagtgacca catcatacgc gacgccgcat 3696781 acaatcccga attagcaaca gataaaatgg ccgttaagat gacaaagttc atgatatctg 3696841 ccgaaaatgg gatgccgatt tgatcgagta ctgctacaaa cgggctttca atcacccccg 3696901 ccgttttgta cggaaggatg gcaaccaaga cgaacatagc gagcacaaag aaaaacagcg 3696961 tgcgccaaat aacatttcga atggactttg gcagtgtttt ttccgggctt tcactttccc 3697021 ctgccgcaat gccgacaagc tccgttccct ggaacgagaa gtttaccatg accagcgtaa 3697081 acataacggc cagcacccca ttagggaaaa gccctctatc agtcataaag ttagacaaaa 3697141 agggtgtctc ctgtccgcct ttaaagtcaa tcaagccaaa cacagcggct ccgccaatca 3697201 caataaataa tatgatcgcc gccactttga tgcttgaaaa ccaaaattcc atttccgcaa 3697261 agcttctgac agagagcgca ttaatcaaaa agatgacgat gccgaacacg aggcaccata 3697321 tccagatcgg aacggagggc agccaccttt gcatcaaaat gcctgctgac gtcagctcta 3697381 accctactgt attggcccag ctgaaccaat acagccagcc aatcataaag cctgtcgact 3697441 gtcccagaaa tttagtggcg taggcctgaa acgatccggc caccggcatg gcaacagcca 3697501 attctcctaa acaaagcatg acgagataca ttaaaaatcc gccgatgata tacgcggcaa 3697561 tggcgccgag cggtcccgcc tggctaatgg taaagccaga gcctagaaac agcccagtgc 3697621 caatcacccc tcccaaagca atcataaaca aatgcctgct tttcatgctg cgctgcaatt 3697681 catttttatg attctgcatc atccttcccc ctttggttct tttgccgtga tggtcatccg 3697741 gtagctttgc aaaagatgaa cggtggtttg ctgtatgagg agaggcaata catgaaatgt 3697801 gtacggttta tagactcgtt ctgtccattt atggccgtct tttccgtaca cgcccatatt 3697861 aatggatgga atattcagct tgcgtatgtc tttgaacgga atggtcccaa tcatattcca 3697921 cccagggaag ttcctgataa aagaatcaat ttcgccatcg gtttcgtgca gtgataaaaa 3697981 actgccgtct gccaagtagg ggaaaaactt tttgaagaca aatgtttcgc ctgtcgattc 3698041 agcggttttg tcagccgctt ctttaatcac atgctgcaaa agctgatctc ttgcgctatc 3698101 ttctttcaaa tagttatgcg gcaggtaagg aggtgcgtaa aatagaatga cttttgcgcc 3698161 ttgatcgggg tcaagctttt gaagctcttc gattgcctga aagcatctca tgcgaagttc 3698221 aaggtgctcg ttggctttga atgtctgctc gatacactgc tcgggatcta ttccccggtt 3698281 tctcagcttt tctaagtatt gctccaggct atacacttga atgccccatg ataaatgttt 3698341 ctttggcagg ttggctcttt ttacatattc ttcgtaataa tctgataatt tttgttctgt 3698401 ctcccggcat gcttcctcag tgacttcaat aagcaaatcc atcatttctt ttgctgttct 3698461 ttcataaata aaacaattga aatacaagct ggtgctgaca gccgtttgca cattatagga 3698521 ttccttgtta tcacgctgat acaaacagga tgggggcaga accaactccc cttcaacctt 3698581 ttctgccaga tggatgttat tgtggagacg gcttgtgatt tcagatgaaa tgaaatttgg 3698641 gtcaatccct gccagtgtat cgccaacatg gacttcacgc ccgtaaatgt aaaagcaagg 3698701 caacagtttt cccgcggctc cggtatagat atatcttgtc tgatcaccat cgtaaagcgg 3698761 ggtaataaaa tccgtattaa tagcagccaa atagtgaagc tgtttttctt tttttagccg 3698821 gttcagctct gaaatgctgg cgagaatgcc cgaatgctgg ctctcctcat cgggattggc 3698881 cataaacaat acatttcccg gcaacgtctc aaggttctcc gaaaaatgca ggagattggc 3698941 taaatgcacg gcgatgccgc tttgcatatc gacagatcct cttccgaaca tccactcgcc 3699001 tgatttggca tcccgctgaa catcctgatc gaactcatag cggctgaaat actcggccaa 3699061 tttctcacaa tcaaaagcga tatcctttaa agggccgaaa tcttcaattc caactgtatc 3699121 cagatgggca tggtaaatga ctgtatttcg gctttctcca tgtcctttaa taaacgcaaa 3699181 aatatttttg cgtttgtatg ggtcattggg aatggcctgt tcccacacat gactggggtt 3699241 ttcctgaaaa taaggatagc tcgtgatcac ttctttgatg aaatctgctt ttgtcccttc 3699301 tccaacggtg ccgttcacgc tgctgaggct gaccagagat gctgtcagcg cctccactct 3699361 ttcagccgga ttcatgtgac tgatttttgt atactgcata aattgtcctc ctgatcaaaa 3699421 agttgaaatc gtgcgatccg ctaaagaatc gcacgatttt atttctctca aatcaaaaag 3699481 cttcggacgt tgttttggct tgcatatgaa gaattaagta atcgggaccg cctgcttttg 3699541 agtctgttcc tgacatatta aaaccgccga acggctgata gccgacaatt gctccggtac 3699601 atcctctgtt aaaatatagg tttccgacat ggaaatcctc gcgcgcccgt tcaatgtgcg 3699661 cacggttttt cgtcagaagc gcacctgtta atccgtattc cgtgttattg gcaatctcca 3699721 gcatatgatc gaaatcacgc gctttgcaaa tcgcaacaac cgggccgaaa atttcttcct 3699781 gcatcaagcg ggcgttttca tcaacatctg caaagatcgt cggctgaata aagtagcctt 3699841 ttgaatcatc gccttctccg ccggccaata gcttgccttc agatttgccg atttcaatgt 3699901 atttcatcac tttgttgtag gatgcttcat gaatcacggg acccatatac gtatcaggat 3699961 cttctggatt gccgacagtc agcgttttgg tcagcgccac agctttttcc accacttcat 3700021 catacacatc ctgatgaatg accgcgcggg agcccgcaga acacttctgt cctgaatatc 3700081 caaatgctga atacacgata gaggatgcag caaggtcaag atcagcgtcc ttgtcgacaa 3700141 gcactgtgtc ttttccgccc atttctgcaa ttacccgttt gagccatttt tggcccggct 3700201 gcactttggc agctcgctca taaatccggc agccgactgc acgggaacct gtaaatgaga 3700261 caaaccgtgt cttcggatgc tcaactaaga aatcaccgat ctccgcacca tctcccggaa 3700321 tgtaattcag aacgccgttt ggcagacccg cttcctccat gacctcgaca aattttgctg 3700381 ccactaccgg ggctgcgtca gccggtttta agagaatcgt atttcctgtc acaatcgctg 3700441 ccaccgctgt tcccgccata atcgcgagcg ggaagttaaa tggagaaatg acgatgccga 3700501 cgccaagcgc ttcgtaatga tattgattga cctcgccagc acggctcttc accggagccc 3700561 cttccttgag ctttaacatt tggcgcgcgt agaactctaa aaagtctatc gcttcagccg 3700621 tgtccgcatc tgcttccttc cacggttttc ctgcttcctt cacaagatag cttgaaaatt 3700681 catgctttct tctgcgcaaa atagccgctg ccttaaagag aatatttgcg cggtgctccg 3700741 gtctttgttt tttccaggaa tcaaatgcct gcaatgcggc ttgcatcgct ttttcagcaa 3700801 gctcttgatc cgctgtagac gcgtacccaa tgatctcttc tttatttgcc gggttaatag 3700861 aaatgatttt gcggtccgtt tcaatttttt ctccatttat gacaagcgga taatgcttgc 3700921 cgagctgagt gtttacaaag gccaatgact ccccaaatgc agttttattc tttgcttccg 3700981 taaaatcggt aaatggttcg tgcgcgtatg tgactgtcat atgtagtccc cctcgtgtta 3701041 tgaaatatat cttcgcatat gaataaaaat gcaagaatca tgccattttc ttgtcttttg 3701101 ctgaaaaaac ttgttgaatc gaacagaaat ttgtctaaca ggtgatcacc tttctctttt 3701161 tccgatcttg aacgcaaatt tattttgcgt tttttgctct ttacgcaaaa aacaaatgca 3701221 aaattatttt gcggaggctt ctcaaattag acccatccgc ggaaacgcga tgcttctgcc 3701281 gattttctga tgcccgtcat gtaagccgcc aaacgcatat ccactttatg tgttgccgct 3701341 gtttgataaa ttgtttcgaa cgagctgacc atgacgcttc tcagtttttc tgcaacctct 3701401 tcttccgacc aataatatcc ttggttgttt tgcacccatt caaaataaga aaccgtgacg 3701461 ccgccggcac tcgctaggat atccggcaca agcagcacgc ctctttcatt caggatctta 3701521 gtggcatcaa tggttgtcgg gccgttcgcc gcttcaacga cgattgacgc ctgaatgtta 3701581 tgtgcgtttt tggctgtgat ttgattggag atcgcggcag gcactaaaat atcgcaatcc 3701641 ttttcaagca gctcctcatt tgtgatgacg tcagtaaata aattggtgac cataccaaag 3701701 ctgtcccgtt tatcgagcaa ataagggata tcaaggccgt ctgggttgta gagcccgcca 3701761 ttggcatcag aaatcccgat caccttcgcg cccgcatcgt gcatgaattt ggccaggaag 3701821 ctacccgcgt ttccaaagcc ctgtatgatg atgcgcgcgt tttgcagctt gatccctttt 3701881 ttcttcaccg cctcttcaat acaaatcgtg acgccctgtg ccgtcgctgt ttcccgtcct 3701941 tgcgatcctc ccaaaacaag cggtttacct gtaataaagc ccggagaatc gaattcccgc 3702001 agccggctgt actcatccat catccacgcc ataatctgcg aattggtgta cacatcggga 3702061 gctggaatat cctttgtcgg accgacgatc tggctgatgg cacggacata ccccctgctc 3702121 agcctttcca gttctccaaa tgacattgtc cgcggatcac aaataatacc gcccttcccg 3702181 ccgccgtaag gaagattggc aatcccgcat ttgagcgtca tccaaatgga taatgccttt 3702241 acttcctctt cattaacttc tggatggaag cgaacgcccc cctttgtcgg accgacagca 3702301 tcattgtgct gtgaccggta gcctgtgaac actttgacgc tcccattgtc cattttgacc 3702361 ggaatgcgga cagtgagcat tctctgcggc tctttcatga gttcatacat atctcccgga 3702421 taacccagct tccgaagggc ttccttaatg attgtttggg tagacagaaa taagttaaga 3702481 gcttcttttt cttcatcttt cgagacttgc tttgctgaca tctttttcac ctcattgttt 3702541 ttttggccgg ctgtaatgta agcgctttaa aaaatcagcc cgccaattcc tttcttcatt 3702601 ggattcaccc ttatcatcat gcaagatccg taccagcttt tgaatccaca aaaaaagaga 3702661 ctgaaaacat ctcagtctct gactacaaat ctatcgatta acggggatca atcaccagct 3702721 gcgtttcagc ataaaaactg ccgattccca aaccgtttac tacatcgcct ttaatcgtgt 3702781 aagtgcctgc gcgaggaaga gttttacgca ccatgacaag gtcaaattcg gatgcgccta 3702841 acaaatcaag cgtaagcggg agtctgactg tttttccatc gtttaaaatc tgtgtttctt 3702901 tcagtgttct tccattcact gaatctcttg tcgtagcatg aaacccgtca ggaaattgaa 3702961 attctaccgc tccaagagaa agcaccgcat ttggtttata tgtcacttca atatcagaaa 3703021 tggtccactc tttcgtgctg ttaactgttt ttgcctcgat tgatgcagac tgtgcatgag 3703081 cttggcccga aggaagtaag attgatagta aaacagctga actgatgaat aatgaagata 3703141 cgaatgaagt tctttttagc atgacatttc cccctaattg attgttgaaa tttggccaga 3703201 gcgtcctctg cagaaaaagc gctttttcat aattcgcgaa ttaccagttc tttttcttaa 3703261 aaattaatct atcatcattt tccatggaag taaatgtttt ttaaggaata ttaacacttg 3703321 gaattcaatg agaattcctt cctgtttata caaggttcaa atggacgatt tccctctctt 3703381 tttctagtaa catctgcctg acattttata tcttttatcc tattttaaaa aagggcaaaa 3703441 aaagtcgaag atgcctctgc tcttcgattg atcacgttcc tatttttatc tgaattcagt 3703501 gttccagtta aaaccgatcg tctcatcatc ccacggaatt cttttttcat caggctgatc 3703561 cgggttatac gacatggtgg taaaatagat aattgtcagc ggcgtctctc ccagcactct 3703621 atatccgtga gccacccctt ttgggattaa taacagcatc gggttgtctt cgcccatata 3703681 atagacgtcc gtttctcctt ttgtctttga atcctctcga agatcgtata ggacaacctg 3703741 agcgtggccg gttgggaaga accagagatc atcctgcttc tcatgataat gaaatgcctt 3703801 aatcacaccc ggatagcttt tcgaccaaga ggcctgccca aaatgctcaa ggagattctc 3703861 atcgtcccgg accagctcag caaaaaagcc tctgtcatcg ctatgcttca tcaatttttt 3703921 caccttgact ccatcaatca cacgcactgc tcctttcctg caaatactct cgtaacgctt 3703981 cccgccagtg gcgggggcgg atgccggctt cttcaatagc ccgatggctc agcacagagt 3704041 atgccggacg gggcgttttg ttcccgtatt cctctgtcgt tacagacaaa atggctgttt 3704101 ccagcccgct ttcttccata attgccgtcg caaactcata ccagctgcat atgcctgaat 3704161 tgctgacatg atagatgccc ggcggatggc tgaacagctt gatgaccgct tctgctaaat 3704221 ccttcgtata agtcggcgaa ccaatttgat cgctgacaac ccgaagctct tgtttcgttt 3704281 cagcaagttt cagcatggtt tcaacgaaat tactgccgcc atgtccgtac acccacgatg 3704341 tcctgatgat cgtgctgtct tttgtcgtta atcgtatcag ttcttctccg agccttttgc 3704401 ttttgccata aatggttttc ggatcgaggg gatcgtcttc cctatatggc tgggttcctt 3704461 tcccattgaa tacatagtcc gtgctgatat gaacatattg agctccgatg cgggttgact 3704521 caagcgctgt ataataagcg ccgattccgt taatcaagta cgctttatca agctctttct 3704581 cgcattgatc aaccgacgta aacgcggcgc tattgaccac gatatccggc tgataatggc 3704641 caaacgaatg ccgtactgag cgctggtcag caatgttcat catcttcttt gttaacgcaa 3704701 tgacctcata tccggcttgc ttcagctggc ggcatagttc caagccaagc tgtcctcccg 3704761 ccccagtcac caataccttt gtcaatcaga tcaccttctc atcggtcatt gtctgtatac 3704821 cactgaatcg tacgcgcaat gccttcttca aacgtcactt cctgccgcca gcccagttcg 3704881 tttttcagct ttgatgcatt gatcgcatag cgccggtcat gcccttttcg gtcttccacg 3704941 tgggcgaaca attcctcaca gcccagatgc ttcaaaatga cactcgccag ctctttattc 3705001 gtgcgttcat ttccgccgcc gatgttatac acctcgccgt cggtcccttt ttctaaaatc 3705061 agcttgatcg cgcggcaatg atcctccgca aacagccagt ctcggatctg gagtccatcg 3705121 ccatacagcg gaacaggcag gccctgcttc gcatgacgga taatcgtcgg aatcattttt 3705181 tcgctgtgct gataaggtcc gtaattgttg ctgcatcgtg taatgatggc cggaagcttg 3705241 tgggttttca cataagacaa cacgagcaaa tcagagcttg ctttgctggc tgagtatggg 3705301 ttattaggag aaagcggcgt cgtttctgta aacgcgggat catccgcttt taaatccccg 3705361 tatacctcat ctgttgaaat atgaatcagc ttcttggctt ttcctttcaa gaccgcttcc 3705421 gccaatcggt atgtccccat gacatttgtg gtgataaacg gctccgcttg ggaaatgctt 3705481 ctgtccacat gcgattctgc tgcgaagtga atgacgccat cgtaggtctc gtcaaaagcg 3705541 cggtcgatat cctcctgaac gctgatgtcc ccttttacaa agcgaaaacg gctgttttgc 3705601 tttaattttt ccatttcctc cgggtggctg gcgtacgtca gtttatctaa aacggtaatg 3705661 cgcgcatccg tttccctcag catgagcttt gtaaacgtga gcccgatgaa gccggccccg 3705721 cctgtaatta aatatgattt tgccatcact tttcgtcctg tcctttccgt aaagcctggt 3705781 gtacaagctg ggaagcgaga taaagcgatt cgtgagttcc ggcatctacc caccagcctg 3705841 ataacacatc atacgtaagc tggctgtttt cgatgtatag attattcaca tcggtgattt 3705901 ccagctcgcc gcgctttgat ggtgatattt gttcaatata tgaaaacacc tctgcatcat 3705961 acatataaat gccggtaaca caaaggttgg tcggtggctg ttcgggcttt tcgatgatgg 3706021 aacgaatccg cttgtttttc tcatcaatct cagcaatccc gaaacgttcc gggtcatcaa 3706081 cttctttcag aagcactttt gctcctttcc cctgctgttc aaagcgttct gtataaggct 3706141 ttaatgaatc ttcaaatata ttatcaccta ataataaaat gaaagactct tttttcgtaa 3706201 agcgctttgc ataagacagc ccatccgaaa tgcccgatgc tgccggctgt acttgataag 3706261 tgatagtaac gccaagctct tccccgttcc caagcagttt gtaaaattgc ggcatatgct 3706321 ccttttggct gatgagtaaa atgtctttta ttccggcttc ctgcagcttc ataatcgacc 3706381 agtatatcat cggatacggg cctacaggaa gcaaatgctt gttgacggct ttcgttaagg 3706441 gcataaggcg tgagccgttt cctccggcta aaataacacc tttcacatta acacttcctt 3706501 acatgcattt ttatatctct tgttcatata aatcttgaag aatagctgtt acccgtataa 3706561 tgcctttgcc atccacgagc ggccttcctc ccttgtgcaa agaaaggcga agaggatagc 3706621 tgctcataat gcgtgacatc tgatagatga gtgtttcatc cggtacaagc tcacccaatc 3706681 caagatcaag agcggcgcct tggtcagcaa atgttttggc tgtagccgtt tgatgctcaa 3706741 cctgagaaag aacaaggcac ggcacgccga tgcaaatggc ttcatataga gagatgccgc 3706801 cagcgacaat ggctgcgtcc gcttgtttca tcaaacctgc catatcattt gtctgttcga 3706861 tcatcttgta ctgcggcttc ttttcgatcc gccttcggac tgcctcttga tgcggtgaag 3706921 cgctccccat cacaaacatc atgtttttgt cttttatgtc ggggacttga tcagcggcag 3706981 ccagcacttt aaaaataagc tgcttcggat cacttcctcc taatgcaaca aggatattgc 3707041 ggcagtcttt cttaagtgtg taatcctctc ttgcggcctg aaaggcgggg tgaagaataa 3707101 gatagtccgg accttcatag atgcgtgtgt ttccctgaac gtacaccctg cttctgatgt 3707161 caccgtaaat tccgttaatg actgcgtcac tatattgaat cgatttaccg tttttctctt 3707221 caaaaagaac aattttcgca tctgtctccg tctttatttt ctttaacagc tctgcaggcg 3707281 cgcctagaat atcaaacaaa agcaaatcaa gcttcttgct ttttatttcc cggagaataa 3707341 attcgtgctg ctgcagctcc ggctttacga tgacctgcca atgctcttca tgaagaaacg 3707401 cttcagaatc ctgattcgta taaaacgtaa tcaagcatcg ctgtttgagc ccctccgcaa 3707461 gcctcttcat ccggacaaca tggcccattc ccttttcata gccgccgtct gcgaagatcc 3707521 caacatgcat ggctagtcag cctctcgttc ggttgccgca tcggggttcc ggttcagaag 3707581 ggtgataagc tctgaggcgg atacatcggg gcgctcgcct gctttttgat agagggcctt 3707641 tatcgattca tagtcttcct ttgtatcaat ggtcagccga tattgagggg cgcgaaatcg 3707701 ttccggcgcc tctaaaaact gaacacgata aagagctgga tgattcctta tatataacgt 3707761 gacatgctcc tgatattgat cctccaaagc ctgaatacgg ctgatgtcaa ttaacaggtt 3707821 ggcgttgacc acttcgccgc aaatccctaa tggggcattc aggatatacg tataatccga 3707881 gccttgatca aaatgcgcct gaatcattac atcgagcagc tcaggatcga caaacggatt 3707941 atcacctgtt aaccggatga tgactgacgg tttaacagct tctatgacct tcacaaacct 3708001 atcgaggaca cgttcttcgc tcccgcggaa aacacgaaag ccttgtttga tacagtgcgc 3708061 ctctaatatg tcgtcagttt ctttgtcaga cgtggcgatg acaagattat cccgatcctt 3708121 ttggtaaaac gcgctttgcc ggacacggtg aacgagaata tcaagtaaac gattcgatcc 3708181 gagcggccga agcacttttc ccggaagcct tgttgaaccc attcttgctt gaatgataaa 3708241 gagaatatca ttcatgaaac gggctgtcct tcagtaaaat gtcatcccag acaatgcctg 3708301 tgtcggctgg aatgtctctt acagcccgaa caccgctggt cagcagttca aaaaatctcg 3708361 ggtgcagccc ctgcggcttt tgtccgggcc gaagcactgc gatattgtct tcactaaagg 3708421 cttcaccttt ttgaatcgga gctgttgtaa aaatgcctct gtatgcaaag tttctgattt 3708481 ctccttcgat ggcggtcgtt gttttgtatg aactgccaag cagtttttca gagaccggct 3708541 ttgtgatccc ctgtttcagc tcagcttccg ttttcctgat gccatcgacc atttctttca 3708601 attcatccgg atttaatgca aacgagtggt cagcacccgg cagattttta tcgatcgtaa 3708661 aatgcttttc tatcagtttt gctccgagcc gaaccgcggc acacggcgct tctgtcggat 3708721 gctcgctatg atcggagaag ccgattaccg cctcaggaaa agcggcggca agcatcggaa 3708781 tgacgctgag gttgctgtac tccggcggtg ctgggtattt cgccacacaa tgcattatgg 3708841 caatttgatt gtttccctct gccctgatgg tgcgccaagc ttcgtgaaca tcagagattt 3708901 cagctccggc tgtcgagaaa atcatcggcc tgttcagccg ggcgacatat ttaagcagcg 3708961 ggagatggtt aatttcatag gatgcgattt taaaagcgct cggcgaggta gactgaagca 3709021 gatcagctga cccctcgtca cataccgtac ttaaaaagat cacctgcttt tcgcggcagt 3709081 aatccaatag cggtaaaatc cactcagcag gcatttccat agattgaacc aaagaaaaaa 3709141 tagagacgtc cttgcccgct gccgtcttgt acaaaccagg atctttctgg tacatcctat 3709201 cagcttggaa catttgaaat ttcacggcat ccgctcccgc ttccgccgcg gcgtctatca 3709261 gcgcaaaagc ctgatcaagc ttcccgtcat gattaatccc cgcctcagca ataataaaaa 3709321 caggagcgtc tttgcctaca gttttattcg cgatctgaaa cgctgccatt atttcgcctc 3709381 cttgcccggc caaatatgat aatagtaata cgattgttca gcggtgaagc ccattcgttc 3709441 ataaaggcgg atcgccctta cattgtgaag ctgcgtcccc gctgttaccg ttctatgctt 3709501 ctgggtctcc ggttgttcta tgagattcgc caataaatga aacgcaatac gtttcccttc 3709561 aaatcccggc tttacagcca tcaaatcgag aatgcactca tcatctcttg ataagccctg 3709621 aagatagccg atgacctcgc cattgtgttt agcgacaata ttgaccgccg cccttccatt 3709681 cagattgttt cgtgtccact cctgaaatat ttcgtttgct gcatcgcggc tgagatgagg 3709741 atcctgaaaa tatctgcttt ttgtaaacga gtctcgggcc agctcacata tcgcttctgt 3709801 gtctccgggc tcaggcgggc ccagttcaaa aaatggcggt gttttgtcat aaaaagacgg 3709861 aggcatcgcc agcttcagca aactcccgac aaagtaagag gatggctgct gttgtatcac 3709921 atgcgcggct ccgatatctt cagccggaac acggacaaag ataaaatccg tttcatccat 3709981 ttggcgtaca gtataaaaag cttcaaacag cctctttagc tgcccggtac tatttgccgc 3710041 aagaagtttg acgttcatga ctttcttctg aagcaccttg ctttcccaca aagaatcttc 3710101 gtaaagcaat acgccttgga gcctgctgtt ttcaaaaagg ccgagggaaa attgatacgg 3710161 aacatccaat gtaagctttc tgctttggag aaattcctca attgcctctt tggagacatt 3710221 ttcttttacc gtatacactt aatcagcccc ttttacgata tcccgcacag cttcaatgac 3710281 atcatctaca tcatcgtcag acattgatgg atagagcggg agagaaaggg ttcgtttata 3710341 gtaattcatg gcattcggaa agtccgcttc cttatatcca aattgctttt gataatacgg 3710401 atgaatgtgt actggaataa aatgaacgct agtgccgata ttgtattcat cctttaaagc 3710461 cgtaatcatt tcgctgcgcg taaccccggc ctttttttca tcaacttgca gaacatatag 3710521 atgccaggcg tgcctgccgt catcatggac aaacggcgtg atcagcccag gaatctgctg 3710581 aaaagcggtt tgatagcggc cggcaatctc ttctctccgt ttctgcatat catccagccg 3710641 tttcagctga tgaagtccga gggccgcctg caaatcaaac atattcatct tatagccggg 3710701 cgattcgact tcatagtacc agctgccatt tgaagaataa cggttccatg cggctttact 3710761 catgccgtga aggcttagca cccgtatctt atcggcaagc tcctcatcat cagtcgtcag 3710821 catgccgcct tcccctgtcg cgaggttttt ggtggcgtaa aagctgaatg ccgttgcatc 3710881 cccgatagaa ccgatcattc tttgcttata agtcgtatat accgcatgtg ccgcatcctc 3710941 cagcacgaat aaaccatgat tttgggcaac agccaatatt gcatccatat cgcaggactg 3711001 cccgccaaag tggacgggca caactgcttt cgttcgcggt gtgacggccg cctcaagctt 3711061 taccgggtca atattgagcg tgttttcgtc aatatccgca aacacaggcg tcgctcccgt 3711121 atgaataatc gtattggcgg tcgagctgaa cgtaagcgga gaggtaatga cctcgtcccc 3711181 gggcccaatc ccttttgctt tcaaagccaa aaataaagct gcggtacatg aattcaccgc 3711241 cacggcgtgc ttcgccccga caaacgcggc aaactctttt tcaaactgct gaaccttcgg 3711301 gcctttagag agccatcccg attcaagcgt ttctgtaacc tcctgaattt cttccttacc 3711361 gattaacggc aatgagtaag ggagaaaatg atttctcttt tgcaccattt ctttgcgctc 3711421 ctatcatttt attcagtatc ttcccgcctg taatcaaccc ctgttttggc tttcagttcc 3711481 gcaaataaag catttgttga ttctgccacc ggataattag ccgctatgaa tgccaggcgc 3711541 gcctcttctg ctttttgatg cacgtcggga cttcgaagaa cctcaaccaa ggtgtgcgcc 3711601 agttcatccg gctggtcaaa cataaaatcg ccaagagact cataatacgg atacgagcga 3711661 tttccggacg attttcctat cagcacaggc ttttgaaaca gcatggcttc aagaccgact 3711721 gtcgaggttt gcgtcactgc ggcatcaaca tacggcagca aatcataaag ctccagctcc 3711781 tttttgatga ctctgcatgc ttgatgtttt ttcgccgcct cgtgatacag atcaagcttg 3711841 ttttttccga tttcccacgg gtggggtttg ataatgattt gcagctgctt ctgatcagaa 3711901 agcccctgca gcacaccgga ataaaagtct tctgaaaagg gctgagtggc aatgagcaca 3711961 atttttttag tcggctgaaa agcaagtttt cgatagaata tggacatatc cataggcgtt 3712021 ctgttaaaaa tctgatcgaa gcggggatgt cccgttacga gaatctgctc gggtttacag 3712081 ccttttcgta tgaaccactc tgcttcatac gcaccaaaaa cagcttgata ggttgtaaaa 3712141 acaggaatga aggcttcatc tcccatcaat gcgccatgct gaagacaaat gctgacggcc 3712201 ccttttcttt gacacatgag agcgagcacc ctgctgtaaa tgtcttctgc cgttccgaca 3712261 ataacagctg aaatcttttc ctgttcaaac agcgcatcaa ctgtatcaat ggcctctata 3712321 aataaaggaa tatctttgaa aagccggtcg cgaaacgctt gatcaccaaa tgccgggtga 3712381 tcatcataag gggcgagaag cgaacaggct gtttcgagat actgcttcga atcgcctttt 3712441 tggcatgaat ccgcaatctc ccgcttgcta attacaggca gatcacaata atgcggcaaa 3712501 ctccatctgg ccaaaacagc cgttttttca ggatcaaatt gatagtaatt ttcgtttgaa 3712561 aaacgcaggt aatcaaagtg caaaatgact ttccctttaa caggttcgtc atttgtttta 3712621 acgatgtttt ggattctttc ttcaaaaaac ggctgaatct gtccctcatc gatatgctga 3712681 tccaccgatc cgaataattc cggttcttct tccatcatca ccctcagttc agggctgatg 3712741 tattgataaa aattactgat aagcccaagc ggaatccctt tgtagcgaag tttgtcaaaa 3712801 agctccacgt acttccggta cagcacccaa taattgctta aataggccga caagctctca 3712861 ccccattcca agctttttta atgattcacg cagctctcgg caatttcgct gcggaggaag 3712921 gttcctgaca aattcatttt tttctaattc aaacagctga aagtgaatcg attggtcggt 3712981 aatataattc aggtccagct cctcatccag tgggtaaaac ggataaaaat gattgactct 3713041 ccaaaagaac cgggcatctc ctatacggta aaacgccggg ctttcatccc aataggagcc 3713101 aaacttctcc tttaccttct caagcaccga atacctgtgc atcaccgagc aatgatcaat 3713161 tgcgcacggc gcgttccatg tcacttgagc ggcaggcctg acagtttctt ttacaatgtc 3713221 acgattctcg tttaaatgat aggttttgga ggctgagtaa atcacagcct tttcaggatg 3713281 ggtatcgagc tcccgcacca ttttcaggag gcggtccggc atatagatgt tgtcatccgt 3713341 cgcataggtg atatattcac cctccgccat ctcaatcgcc tgattgatca gtgccgcgta 3713401 tctcgttttt tctgttcttt ccttcactcc agatatatcg ctttgataaa aacgcactcg 3713461 gttatcattc aaaaaaggac ggattacatt cagcgtctct tcattggagt tgtcatccat 3713521 aataaacaat tcaaaatctg aaaacgtttg tgagagtatg ctagaaatgg actttgccac 3713581 ataatcgctt ttgttatagc tcgtcataat gactgatact ttaggcaaat cctacacctc 3713641 cttcttggaa cttcacacct gaaactatcg ttatcttatg ttgcttatgc tcaagttgcg 3713701 ctagggatac aaaccaatat gcgaaaagtt tgtgtatgtt tctgaaaaac agcggctgcc 3713761 cagagcgaaa tctgatcggt ccgctgttct ttttcagcat aatccaagca tcagcctcat 3713821 aaggtgaaag agataaaaat cgcaccagcg actaagatcg ttttccatcg gaggtgagtc 3713881 atcgcggagc gttcacctat acatccagaa catgttttga atggttttca taaaaaggag 3713941 gaacgatatg aaaccgaaaa aaaatcaata tcagcaaatg caggcatttg ataatatgca 3714001 ggggtatcag cctcagtttg gcgccaaccc gtacccgcag caaggccaag gctcacaaat 3714061 gcagacaatg gggatgcagc caatgatgcc aatgcagcag ggacagcaag gacaacaagg 3714121 acagcaggga tttggattcc cgggccagca gcagggcggc ggttttcaaa ttccatcggg 3714181 gcctacaccg tcaggaccgg gccaaagcgt tcccggcatg ctgcctgttg aggaatctta 3714241 catcgagaat attttgcgcc tgaatcgggg aaaaacggcc accatttata tgacatttga 3714301 aaacagcaag gaatggggct cgaagatttt tcgcggcgtc atcgaagctg cgggccggga 3714361 tcacattatt atcagcgacc cgaaatcagg aacacgctac ctgctcctga caatctacct 3714421 cgattacatt acatttgatg aagaaattgc ttatacgtat ccatattcca tggcgtccta 3714481 ttcgccaaga taagaaaaaa gccaatcact catatgatga ggattggctt ttttgtttat 3714541 agatatttga cggctgcgac aacgatcata atccaagaaa taataaacgc cacaccgccg 3714601 agcggggtga tcgctccaag aatggagatt tgcgtcacac ttagaatata taagcttccg 3714661 gaaaacagca caattcccgc aaacatcagc cagccggctg tcgtgacact gcctatgccg 3714721 gataatttat cagccagaaa cgcgacaacg aataacccaa gggcgtgata catatgatac 3714781 tgcacgcctg tgtgccaaac ctgaagatac ttatcaggta ttttcccttc taatccgtga 3714841 gcgccgaatg ctccgagtcc cacggcaagc agggcgttaa tggcccctaa tatgataaaa 3714901 actttcatct atctctcccg ccttttcgtt aaactcatat catttatctt atcgcacctg 3714961 caccaaaatt caatgtttgt tctccgttga cacgagattg tcggattttc tcctgcgcca 3715021 aagctggaac tggtcagctg ctattgcagc aagcgtccct aatacgagcc cgttgcttaa 3715081 tagagaaata aataccggat gcaatccctt taacgcagtt tcaggaacaa acatgatacc 3715141 gacccctgtc agcagtgaga taccgatgat agacctcacc ctttttgatt cttctttctc 3715201 atatgaatca aattcggcaa aggccagacc gcccattgcg gagaacacaa caaaattcac 3715261 cgcaaatcca acgggtgacg gcaggctcgc aaacgtattc ataaaaaacg ggatcacgct 3715321 gatcacgata accagaatac tgccgagcat aaacggtttt ttagaaggca tcttggtcgt 3715381 ttcaataaaa cctgcggctc ccgaaatcgg aacaggcgca atagctcccg tcaaaccgct 3715441 aagcagatgg ctgaatgaag ctgcaaaacc ggcatggcgt tcatgatgct ttccatcagg 3715501 ctgtttgctg aattttttca tggcgatgtc cacgaccttc atgctcgcca gcatattcac 3715561 gatcagcaag atggtaataa aaatagaagt gatgatcagg ccgctgttaa ataacggggt 3715621 cccaaaagga aacagggaag gcagctgaaa cagccggtcc ggcatttcaa tcggctttgc 3715681 ggctccggca gccgcaaaca gcacccaccc gccgaacaag gctaataaaa tagaatattg 3715741 cttaaaaaac atgatgttcg aatttgtcat tataaaagcg gcagcgatca caacaagcgc 3715801 caggccaaat acaagaccgt ccaccccgtc ctgtcgataa ccgattccga gaattccttt 3715861 tataatgggc tgactcagct gcatgacaag aagcaataaa tagacgcccg ttacaaccgg 3715921 agtaaacaat tttgcaagtc tgtcaatgac cttgaaaaca cttaacaaaa agaaacatac 3715981 agcgcttaca agaagagctc cctgcaaacc ccgcagtgtg tctccatatg tcgcaaacac 3716041 agttcccgtc agccctgcgt aaatcgtata cactccccac cacaagccgg ctgggctttc 3716101 attgatcggc agtctgtggc ctttcaaaca ctgaatgacg gcggcaattc ccagtacaaa 3716161 aaaagtgctt tgaatcaatc ttgcagaatc tgagtgatcc agatgaaacg actgggcaac 3716221 cgccaccgga acaacaatcg ccgcagcaat aataaacgct gtccattgca gcgcgccaag 3716281 aaccaatttc acgtaagctc aacctctctc tttaaaaatc aaataaagac tctccgtttc 3716341 catcctcttc ctgcttctct ttttcttgct ttcgatattt gtttaatccc gcgctcccca 3716401 tcattttttc catcatcagc tggtctgtcg atggcggcgc ggcgggactt ggcgtaacgc 3716461 tcggctgtat gcggggcgcg ctcgcgttct ccggctgatc aagcacgaca tcacacagag 3716521 aacggacaac cgctacataa cgcttcagct cctcatcccg ttcagccgtt tttgcttttt 3716581 ttagctcttc ttccatcttt tgaatcaaag cagatatatg aatgttcatg aagcaccctc 3716641 caaaaaaata aatgttgtct tcctgcattt tatcaaattc ctgctgaaaa cgcagatatg 3716701 agtttgttat tttttctgac aaaccttgcg cgattgacaa gcagaagaga tttttcacat 3716761 aataaatcac cataccttac aaaaaggaga aacggaatga acagcatccc ctctatcatc 3716821 agcaagcata aagcctattt tgcggcggga catacgagac cgcttgaatc gagactgaac 3716881 attttgcgaa agctgaaaca agccgtcaga actcatgaag ccgatctcat agccgctctc 3716941 taccaggatc tccataaatc cgagcaagaa gcatactcaa cagaaatcgg aatcgtcttg 3717001 gaggaaatca gctttgtcat gaaacggctg agaaaatggt ccaagccgaa acgagtcaaa 3717061 acgccgttga ctcatctagg ctccaaaagc atcatcatcc ctgagccgta tggaaccgtt 3717121 ttggtgattg cgccttggaa ctatcccttg cagctggcgc tttctccgtt gattggcgcc 3717181 attgcggcgg ggaacacggt cgttctcaag ccatcagaat atacgccggc tgtttctgct 3717241 attctttcca aactcatcag cagcgttttt ccaactgatt atgtcgctat ggcagaaggc 3717301 gggcccgatg tcagcacagc attattacag cagccctttg actacatttt ctttaccggc 3717361 agtgtagctg taggaaaaat cgtcatggag gccgccgcca aacaattaat tcccgtaacc 3717421 ttggagctcg gcggcaaaag tccctgcatc gtccataaag atgctgacat tcagcttgcc 3717481 gccaaacgca tcgtcttcgg gaaatttaca aatgcgggac aaacctgcat cgcaccggat 3717541 tatttatttg tccacgagga catcaaaacg aagctcacag aagaaatgaa gcgtgcgatc 3717601 agagaatttt acggccctca gccggaacgg aatccacagt acggcaaaat cgtcagtgag 3717661 cgccactatc agcggctgct cagctttctg aatgatggca tcccgctcac aggcggacaa 3717721 tctgatccca atcatcacaa aattgcgccg accattctcg aacaagtgag agatgactct 3717781 ccagtgatgc aggaggagat tttcgggccg attcttccgc tctttacata ccgcaatatc 3717841 ggggaagtca ttgagaaagt ccaatcgcgc cctaagccgc tcgccctgta tctcttcacc 3717901 acaaacaaag aaattgagcg cgctgtttta ggaaatctgt cgtttggcgg gggctgtgtc 3717961 aatgatacgt taatgcatgt tgcgacgccg tatttgccat tcggcggcgt cggggaaagc 3718021 ggcatcggca gctatcacgg gtttgacagt tttaacacat tcacgcacaa aaaaagcgtc 3718081 gtcaaacaaa cgaaccgttt cgacttcgca tttcgttatc cttcctccaa aaacgggctg 3718141 cgaatgattc gaaaaatact caaataaaaa agcgcagatc acctgcgctt tttacaaatc 3718201 cttaatacac caatcaatcg gcgcctctcc cattttctcc aaataggcat tcgcccggga 3718261 aaacggtctg ctcccgaaaa atccgtttct cgcagaaaac gggctgggat gcgtcgattc 3718321 aatgataaaa tgcttggagg tgtcgatccg ttcttttttc atttgagcat gccgtcccca 3718381 caaaataaag ataaccggcc gctctctttc actcagcacg tcaataattc ggtccgtcag 3718441 tcgctcccag ccttttccct tatgggaatt cgcctgtccg cgccttactg tcagcacagt 3718501 attcagcaaa agaacgcctt gctttgccca gctcacaagc gacccgtgat tcgggatgct 3718561 gcacccgatg tcctgctgca gctcaagaaa gatatttttt aacgaaggcg gctgctttac 3718621 accgggcttg acagagaagc ttaaaccttg agcctgtccc ggcccgtgat acggatcttg 3718681 acccaaaatg acgaccttga catcatcata tgatgtataa tgcagcgcgt tgaaaatatc 3718741 ccggctgtcc ggataaatcg tttgctccgc gtattccctc ttcagcatct ctctgagctc 3718801 ttgataatac ggtttctcaa actcttcctt tagctgattc caccagctgt cttgtaaaag 3718861 ctgtttcaag attcaggcct ccttacgaac gatgaagtct ggaatagaca ggctcgccat 3718921 cccaaaccat ttcacttttt gcttcccgcc tcttcatctc aggctcttca agcaggacgg 3718981 caaagttttt cgtcggcagc tccccgagtc cgtgcttttc acttaaacga tccaaatatt 3719041 gcttccgctt ggcgccaagg tcagcagact gattgtctcc cgcgtcactg aaggcataaa 3719101 tcacgctggc gcaagggaca cgcttcaccc ggtaatcctt ggccgcgcgc aaataaaaat 3719161 cccagtccca gtaattgtgc acatcagcat cgaaataccc gatttcatca tgcagaaaac 3719221 gtctgtacat gctgcccgac ggcacgtatg tagaaaacac tctcatatcc tcatagtcag 3719281 cggtataagc aaacaatttc cgtgacactg gataccttgt tccgtttttc tcttcaaacg 3719341 aaactatttc cgcatcagaa tgaacgaagt ctgccgtttc tatttccttt gccattttct 3719401 cgatatgccc tggcgtaaag aaatcatcgt catcacacag cataatgcaa tccccagacg 3719461 cctcttttac accggcattt ctcgcagcca catgccccga gttcttttct aaattgatga 3719521 cagcaatcgg cagctccgga taaagtgctt tgaccggcac gaccgattcc ccggcatcat 3719581 tcacaataat aatttcatac ggcatcaagg tctggcggga aatcgactcc aaaagctcac 3719641 acaaagccgg aatccgatta taggtcacaa ttacgataga aatcttcatg atgctctcct 3719701 tctcattttc atagtcatgt actattaaaa catatattgg acgggagatc agtgggaata 3719761 tcctactgaa acggcatact acaatgatag aaacagcaaa gtggctccga tcagaagcac 3719821 catgatcagc atcagatctc caaagacatg aaagatatct ttcatgcgga cgccattcgg 3719881 aaggataaga cgccacagct tagattgata gaccggcagc agcaccagtg cataagaaag 3719941 acacaaaaat gtaaaagccg gcggcacaaa agcacagcct gcatcgtccc aattcatcat 3720001 gatgtctttc atactagatc catccaataa aaacaaagat atcatgaggg ctagcaacac 3720061 aaaggacccc aattgaacct caaacaggcg cattttctgg ttatatgcaa atcggaccgc 3720121 ccaaaaccag acataagcat atgaacatag cagcgtaaga atggcacctg ctgtaaagac 3720181 gacatcaggc agccgatcaa gcagaaaaac aaaaggcaag ctggctgcca tagccaagag 3720241 catgcagcca ccagtaaaca aaaatactgc cccatgagct acaaaaccat ataaacaaga 3720301 gctaatcctc acgacataca cctcctttac atagaaattc tatgtatata cctaaaaaat 3720361 cagacaagct gacgcctgcc aatataacag cccattcggc caaataacgg aaataacagc 3720421 gttgcaaaag cacaagttcc aacaaaccaa ggtgtcaaca aggattgaaa cagcgcagca 3720481 ggaattacat tgaatagaaa aacaagcata aaaatgacgt ttggcaccat tgagatcaga 3720541 atcgtatgta gaacaagctt ttctccgcgt tttccaaact ccttcacgcc ttgataccca 3720601 atcagcaccc agtagatcat atatgcagct aagatcagcc aaacagaaac agaaatgcct 3720661 ttccatactg cttgaacaaa cggtgattca agccatacat gcattattgt aatcgcaatg 3720721 ccgacagcga atagggcact gttacagaaa agatggaaca tcaaaaacgc acgaaacgtt 3720781 actggctgta ttttcttaaa cgaagaaaca atgtcagttg gtgttccaaa cgcctgcaat 3720841 aaagtctgca tagcttcctc ctcactcttt ccttcctgaa aagagcgaaa cagatgatgt 3720901 tcaatatggc tctcaatctc ttctatcatc gcctcaccct caggaagccc tttaagcccg 3720961 cttttgattt cggatacata tgtttcttta tccattttgt ccgctccact tcagtattcg 3721021 gtccatcatg gctgaaaata cgctccattc cttcgtgcgt tccgccagca cttctttgcc 3721081 ctcgtctgta atccggtaat atttgcggtc cggtcctttc tcctgcttct cccagtagga 3721141 agaaatatac ccttggcgtt caagcttgtg aagagaagga tacaaggtcc cttctttcat 3721201 ctgcagttca tttccgctgc ggcttcccat ttcttttaca agctcatagc cgtacatcgg 3721261 ccgctcgttc agaagcgtca ataccaatat aaccgtgctt cccttaacca gctcacgatt 3721321 taacatctca aaacccctac ctagttttct tatgtagcat tttacgaaag cccgttgaga 3721381 ttgtcaaatg attcctatag atcttctata ttgtgataca gagaaaatct aactataatg 3721441 aaagacaaaa catgatggag gttcaagaca tgtctatgca taaagcactc accattgccg 3721501 gctcagattc cagcggcggt gctgggattc aagctgattt aaaaacattt caagaaaaaa 3721561 acgtatacgg gatgaccgcc ttaacggtga tcgttgcgat ggacccaaac aacagctgga 3721621 accatcaggt attcccgatc gatactgata caatccgcgc ccagcttgca acaattacgg 3721681 acggcatcgg cgtggacgcc atgaaaacag gaatgctgcc aaccgttgac attatcgagc 3721741 ttgcggcaaa aacgatcaaa gaaaaacaat taaaaaatgt ggtaattgac ccggttatgg 3721801 tttgcaaagg tgctaatgaa gtcctttatc cggagcacgc ccaagccctg cgtgagcaat 3721861 tggctccgct agccactgtc attacgccaa acttgtttga agccagccag ctcagcggca 3721921 tggatgaact aaaaacagtt gacgatatga tcgaagccgc gaaaaaaatt cacgcactcg 3721981 gcgctcaata tgtcgtcatt acaggcggag gcaaactcaa acacgagaaa gccgttgatg 3722041 ttctctatga cggagaaaca gcggaagtcc ttgaaagcga aatgatcgat acgccttata 3722101 cacatggcgc aggctgtaca ttctcagcag ccgtgacagc ggagcttgcc aaaggtgcgg 3722161 aagtcaaaga agccatttac gcagcgaaag aattcatcac agcggccatt aaagaatcct 3722221 tcccgctaaa ccagtatgtt ggtcctacga agcattctgc actgcgcctg aatcaacaat 3722281 cataaaaaaa ggggctgcct tacagagagg cagccctttt taaatcaccg aagacttttc 3722341 acagaaaaaa ctgccgatcc catcggcagc ctgtttattt gatttttaaa ttgtttgcag 3722401 atttcctcaa aaatgtttct atcgactgaa caaaaagtgc atattccttc atttgttcat 3722461 atgcccgcgt gagaatttcc gccgtttcac tgtgcggcgt tgttccgcca agcatttttt 3722521 tcagctgaag cagcacatcc ttatattctt ctcgcttatc ttcaacttgg ttagcagcct 3722581 tttccaaaca ttccggtgtt atcttctgtt catgtatatt caagaaaaca actcctttta 3722641 cagaaaaaaa tagtaggtta tcgttgaaga atagcacaga tggctcagat ttcacataag 3722701 aaaatagaag gattttctac ataagtgtcc aaattccgac attcatttca gatttcccgg 3722761 tcgcactggc tgttacttca tgatttcccg ggaaaggaaa atatcttgca ctcaagacct 3722821 cttctccgtt attgataaag atttccacag atgacgcgtc gagaaacatg tgtacggtat 3722881 gcaaatcctt gatgcggcaa tgtctcgctt ctgttctttt tccgtcaaag ctctttcgtt 3722941 ccagcgtaac aatcccctcg tctttatgga aggaaaacgt agccgttccg cggatactga 3723001 ttgaaaagcc agactccgta tgaatgtctt ccagtagaat ctcagttctt tcaggttttt 3723061 ccactggaag cgcaccagat gatccatgca tgttgatgtg tatttttttc tcatttctgc 3723121 gcatggcttt tagctcaggc agcggctgct gaatcagctt ctgtcctgaa agcgtcagct 3723181 gtctcggcag cgtcatgcag tgaatccagt ggcagtcaat ggtcggatgg gacccttcat 3723241 cctgatcagg caccgccatc catgcaaata aaatccgcct tccctgatcg tcttcaagtg 3723301 tttgcggcgc gtaaaaatca aaaccttgat caagctccgt aaattcacca tgcttcagtt 3723361 caggcttgtt ataatcgagg cggccgacaa aataacctga ttgatatacg ttctgataac 3723421 ggaaaccgtc agcctcaagc ccttgaggcg aaacaatcag cacatccgat ccttgaaggg 3723481 aaaacaaatc agggcattcc cacatgtatc caaaatcgtc cagcccgttg aagcccgcgc 3723541 cggttatcgg gccaagaaat ctccactctg tcaggttatc agaagcaaac aacacagcct 3723601 gccctttcaa attctctgtt tgcgcaccaa tcaccatata ccatgtgcct tcatgctccc 3723661 ataccttcgg atcgcgaaaa tgcgccgtat atccttccgg aaggcgggcg acgacaccct 3723721 ttttctcaaa ggacagcccg tcgtcagaaa cagcaaggca ttgatacgtt tcccgatttc 3723781 catcctgatc cctgacattt cctgtgtaaa aaagatagag ccgatcgtct ttcgtgacag 3723841 cgctgcccga gtagcagccg tttttatcaa accaatcact cggagccagc gcaatctctt 3723901 cccgcttcca attcacaaca tcctgtgtcg tataatgccc ccaaaatttt gcgccgtgcc 3723961 ccgtctgaaa cggctgccac tgaaagaata catgatagct gcccttccaa taaatcacgc 3724021 cattcgggtc attcagcagc ccaaccggcg gcatgatatg aaaatgctgg cggtgcggat 3724081 cgctgttagc gatgggctct tttttctcca cttcttcata agcccggcga cgaagctcct 3724141 ggtcatgtgc tgtcattttt tcctctcctc atcctcatta atcttcatga caaatgctgc 3724201 aatgaacgct gacactgccg caatcgccat gccaatcaga tagtgaatca agttgctgaa 3724261 gccaaacgga gccgcaatgg cgatcatcgg aattcccgtt aacccgtaag cgtttgcagc 3724321 tacatgtgta aagacgacat atgccccacc caatgcgcct ccgatcatcg cggcgataaa 3724381 cggttttcgg tagcgcagat tgactccgaa tatgacgggc tcagtaatgc cgagaaaagc 3724441 ggaaaatgct gccggaagcg cgatttcttt tgtctttgcc tttttcgcca taaagaagac 3724501 ggcaagacct gccccgccct gtgcgacatt cgccattgac cagatcggca gcaagtagtt 3724561 tttgcctata tctgcaatta gccctgcctc aatcgcatgg aagctgtgat gaacgcctgt 3724621 cagcacgatg agtgaatacg tgcccccgaa aatcagacct gcgacaaaac cggcatggtc 3724681 atatacataa gttaaagcaa ccgtaatgcc ggagccaagc gctctgccta gagggccaat 3724741 cgcgataaaa gcaacaaacc cggtgacaat cacagtaaca aatggtgtaa caagcaaatc 3724801 caccgcatgt ggaaccactt ttctcgtcca tttctctacc ttgctcatca catacaccgc 3724861 aagcaggaca gggataacag ttccctggta gccgagaaga gcgatatcaa atccgaaaag 3724921 atgcatgtaa tcaggtgtcg cttccgccaa tccccatgga tttaaaagat tcggatgaat 3724981 catgattccc ccgatgaccg ctcccaagta tggattgctg ccaaactctt ttgaagcgct 3725041 gaccccgatt agaatcggca agaaaatgaa tgctgcactt gaaaacatat caagcagctg 3725101 caaaagcgca gaatccttgc tcatccaatg aaacgcattg atcataccca gcaatcccat 3725161 taataggccg ctggctacaa tagctgggat gattggaaca aaaatattag aaagcgtttt 3725221 cgcaaatctc gcagcgggat tcagcttttc ttttgccgca tcctgatgat tgacgtgttc 3725281 ttcacgctcg atatcagctt ctttagaaaa ggcatcgaat actttattca caaggcctgt 3725341 tccgaaaatg atctggtact ggccagagct gctgaaagcc cctttaacgc catcaagctc 3725401 ttctacttgt gcttgatcta tctttgattc atctttcatc actaaacgca gtcttgttgc 3725461 acaatgagcc gcgctgataa tattttcttt ccctccgaga agctcaatga ggcgttttgc 3725521 agtctctttg taatccatct atttctcccc cttttattta aacaaaaaag acctaaaatt 3725581 cgccaacgaa taaaggacac agcgatcctt tttcatttac gcaaatttta ggtcttgcct 3725641 gctttaccag tcacaatccc gcttattcag attaagaata cgctttcatc ataaatcatg 3725701 atagcgtttt cgtcaactat ttttttagtt aaatagtttg atataacatg tagacaaaaa 3725761 ttcgtaaaaa ttaattgtga aatacttcac aatatcgtgc tatactatgc tcaatcatga 3725821 aagaaagcag gaaaagacaa tggaaactca agcattacaa aaggttgaac agtatgcttt 3725881 gaaaaaacaa aacatattcg cttcaagcaa aatccgttat gtgcttcggt ccattttggc 3725941 cagtatattt attggttttg gcattacagc cgcaagcaaa acaggcagct atttctttat 3726001 ggctgattct ccgtttgcct ttccggcagc cgctgtcact ttcggggccg ctattctgat 3726061 gattgcttac ggaggcggag atttatttac cggcaacacc ttttatttca cctataccgc 3726121 gctccggaaa aaaatcagct ggcgcgacac cctatacttg tggatgtcaa gctatgccgg 3726181 caatttaatc ggcgccattc tgtttgccat cctgatcagc gcgacgggac tttttgagga 3726241 gccttctgtt cattcctttt tgattcattt ggcagagcac aaaatggagc cgccggcttc 3726301 cgaattgttt ttcagaggaa tgctgtgcaa ttggcttgtg tgcctcgcct ttttcattcc 3726361 aatgtctctc aaaggggaag gagcaaagct ttttaccatg atgcttttcg ttttctgctt 3726421 ctttatttcc ggctttgaac acagcattgc caatatgtgc acattcgcca tctcgctttt 3726481 gatcgagcac cctgatacag tgacactgat gggagcagtc agaaacttaa tccccgttac 3726541 gctcggcaat ctgaccgcgg gaatagttat gatgggctgg atgtactaca cactgaatcc 3726601 tgatcaataa aaaaacttcc agagatcact ccctgcaagt caaagcggtt attccgagag 3726661 atcttgaaga cgctggacat gcagcgtgat atagccggcc tcggattccg gcaaatgtaa 3726721 ttgatattca tttttcaaaa actccgccag ctccagcgca cattgatagg cgaatgaata 3726781 ctttttttgg atgaaataaa gcatctcctc gtccatacga tggagcgctt catttgattc 3726841 caaccggctg accgcgtatc gcaaatgcgt gacaaggcgt tgataggaaa tgctgttttc 3726901 atccaccttt cgattaaagt attgttttat tttctctatc atttctttga tcatggtcgt 3726961 atgcttcagc gctgaataca tgctctccgc atccatcttc gccgtatgga tgtgaagggc 3727021 aatataaccc gcttcatctt caggcagaga cacgcccaat gtctctttta catgtccgat 3727081 cgcccacagg ccgatctcat attctttttt atagagcgcc tttatctcat gcagcaattt 3727141 attctgcaca agcagcccat tttgaatcct ttcgatcgca aaggacaaat ggtcggaaag 3727201 cgcgatatga atgtgatcgc tcagcggcgc cgcgagctct ccttccgcat agctgatgat 3727261 atcctcagct atttctatat gctcctccgg cagtgtttgc aggatttgtt tgaacttttc 3727321 attctcgtcg cgcacgacaa agatcttttc cactttattc atagggatga gatcattttt 3727381 ctttttttga aaagcgattc ccggtcccat cacgattttt tcctgatcat cctcttttat 3727441 taaagccgca ttgttgttta atactttata gattttcaag aggttatctc tcccgccaat 3727501 ttgcttttga ctgggatttt acctcctttt gaccgccatg taaagatgcg ggcccgctct 3727561 ctcctgcttt ggcgattcct tgaaggcttg caaacatctt cttttataaa gcgcggcggc 3727621 tttcgctttc tgcttttctt cctcattcac agccatccgc cattcataaa acgaaacgag 3727681 tcctgcggcc tgcacagccg cctttctttg gtatgtacgc tgagccgaat agaccgcggc 3727741 agccgcagtt tttctgtccg gcgtcaccca gttcatcaaa aagaccatcc acacccgtaa 3727801 agatacaagc aaacgtttca tagaaaaaca tccctccgct tctttttggc aggcagcctt 3727861 tttagcagcc cgttttctca gccgcagccc gcaagaaaag acggccgatt tcttttctcg 3727921 caaactagcg gctctagcaa aactcatgac tctatgatag accgtggaaa gagaattctt 3727981 tgtcacaata tgagtgaaaa aaccaactag tttttagaag ttttgttgaa agctgaaaga 3728041 attgaaatga aaattggaga accgctttga aaactttata cacaagttat cccaaagata 3728101 agaacaactt aatcacaaga gatatccaca tgtccacaaa ctctatctat attttgtata 3728161 cgaacgtata ttcctaacta tatatataca caggtttatt cacttataca cagggttctg 3728221 tgtataactc cttcgttata cacaaacaaa atccaataaa tggtccaaat gacacaagga 3728281 tttttttgaa ttttcaagaa atatatacta gatctttcac attttttcta aatacaaagg 3728341 gggaaacaca ttgaaaaagg ggatcattcg ctttctgctt gtaagtttcg tcttattttt 3728401 tgcgttatcc acaggcatta cgggcgttca ggcagctccg gcttcttcaa aaacgtcggc 3728461 tgatctggaa aaagccgagg tattcggtga tatcgatatg acgacaagca aaaaaacaac 3728521 cgttatagtg gaattaaaag aaaaatcctt ggcagaagcg aaggaagcgg gagaaagcca 3728581 atcgaaaagc aagctgaaaa ccgctcgcac caaagcaaaa aacaaagcaa tcaaagcagt 3728641 gaaaaacgga aaagtaaacc gggaatatga gcaggtattc tcaggcttct ctatgaagct 3728701 tccagctaat gagattccaa aacttctagc ggtaaaagac gttaaggcag tgtacccgaa 3728761 cgtcacatat aaaacagaca atatgaagga taaagacgtc acaatctccg aagacgccgt 3728821 atctccgcaa atggatgaca gtgcgcctta tatcggagca aacgatgcat gggatttagg 3728881 ctacacagga aaaggcatca aggtggcgat tattgacact ggggttgaat acaatcaccc 3728941 agatctgaag aaaaactttg gacaatataa aggatacgat tttgtggaca atgattacga 3729001 tccaaaagaa acaccaaccg gcgatccgag gggcgaggca actgaccatg gcacacacgt 3729061 agccggaact gtggctgcaa acggaacgat taaaggcgta gcgcctgatg ccacacttct 3729121 tgcttatcgt gtgttagggc ctggcggaag cggcacaacg gaaaacgtca tcgcgggcgt 3729181 ggaacgtgca gtgcaggacg gggcagatgt gatgaacctg tctctcggaa actctttaaa 3729241 caacccggac tgggcgacaa gcacagcgct tgactgggcc atgtcagaag gcgttgtcgc 3729301 tgttacctca aacggcaaca gcggaccgaa cggctggaca gtcggatcgc cgggcacatc 3729361 aagagaagcg atttctgtcg gtgcgactca gctgccgctc aatgaatacg ccgtcacttt 3729421 cggctcctac tcttcagcaa aagtgatggg ctacaacaaa gaggacgacg tcaaagcgct 3729481 caataacaaa gaagttgagc ttgtcgaagc gggaatcggc gaagcaaagg attttgaagg 3729541 gaaagacctg acaggcaaag tcgccgttgt caaacgaggc agcattgcat ttgtggataa 3729601 agcggataac gctaaaaaag ccggtgcaat cggcatggtt gtgtataaca acctctctgg 3729661 agaaattgaa gccaatgtgc caggcatgtc tgtcccaacg attaagcttt cattagaaga 3729721 cggcgaaaaa ctcgtcagcg ccctgaaagc tggtgagaca aaaacaacat tcaagttgac 3729781 ggtctcaaaa gcgctcggtg aacaagtcgc tgatttctca tcacgcggcc ctgttatgga 3729841 tacgtggatg attaagcctg atatttccgc gccaggggtc aatatcgtga gcacgatccc 3729901 aacacacgat cctgaccatc catacggcta cggatcaaaa caaggaacaa gcatggcatc 3729961 gcctcatatt gccggagcgg ttgccgttat taaacaagcc aaaccaaagt ggagcgttga 3730021 acagattaaa gccgccatca tgaataccgc tgtcacttta aaggatagcg atggggaagt 3730081 atatccgcat aacgctcaag gcgcaggcag cgcaagaatt atgaacgcaa tcaaagccga 3730141 ttcgctcgtc tcacctggaa gctattcata cggcacgttc ttgaaggaaa acggaaacga 3730201 aacaaaaaat gaaacgttta cgattgaaaa tcaatcttcc attagaaagt catacacact 3730261 tgaatactca tttaatggca gcggcatttc cacatccggc acaagccgtg ttgtgattcc 3730321 ggcacatcaa accgggaaag ccactgcaaa agtaaaggtc aatacgaaga aaacaaaagc 3730381 tggcacctat gaaggaacgg ttatcgtcag agaaggcgga aaaacggtcg ctaaggtacc 3730441 tacattgctg attgtgaaag agcccgatta tccgagagtc acatctgtct ctgtcagcga 3730501 agggtctgta caaggtacct atcaaattga aacctacctt cctgcgggag cggaagagct 3730561 ggcgttcctc gtctatgaca gcaaccttga tttcgcaggc caagccggca tttataaaaa 3730621 ccaagataaa ggttaccagt actttgactg ggacggcacg attaatggcg gaaccaaact 3730681 tccggccgga gagtattact tgctcgcata tgccgcgaac aaaggcaagt caagccaggt 3730741 tttgaccgaa gaacctttca ctgttgaata agaaaaagcc ctgccgattc ggcagggctt 3730801 tttaaagatc agtcagcaaa cgcctcctgc aataagcgat acgatcggag cttatcttca 3730861 aaatgatgcg tgatggtcac caccatgatt tcctctgttt catacgcgtt actcaaagct 3730921 aacagccgct ccttaacctg ttctttcgta ccaacaatca ttcgatttcg attatcagca 3730981 attcgtctct gttcataagg agaatacgta tttttccgaa cagcttcata cgaaggaact 3731041 ccctctaaag gaataccctg ctctcccgcc aaaagtgtaa aatcaagcac agccccaagc 3731101 tcctctgcct tctcctccgt gtcagcacaa agaacaaaaa cagcaactgc cgctcgaggc 3731161 gtatctccta acacagacgg tttgaatcgc ctcttatact gtctgacagt accctctccg 3731221 ccctctccat tgataaaatg ggcaaacata tagccagcgc cagattcagc tgcgagcagc 3731281 gcgctttctc cagatgagcc gagcagccac acatccggag ccgttgaaat atgcggcgca 3731341 gcggtcagat tcggaaaacg gtgtttgtca tccgccaaat catgcaaata catggtcagc 3731401 tccttaattt gctgcggata ctgatcagca ttgcgcttac caccgtcatt cagcgcccat 3731461 gatgcaatcg gcattccccc cggtgctctg ccaagcccca ggtcaattct tcctggtgtc 3731521 agcccctcca gaacacgaaa gttttcagct actttataag cactgtaatg cggcagcatg 3731581 actcctcctg atccaacacg aattcgcttt gttttcgctg ctatatgact gattagcacc 3731641 tcaggactgg accctgccag ccgttttgaa aagtgatgct cagaaaccca aaatctctta 3731701 tatccaaggt cctcagcagc ttgggcaagc gcaacggttt gctgtaaggc cgtttctgca 3731761 ttgctgccct ctgatactgg agattgatct aatatactta atgaaaccat ccctaccacc 3731821 tcatcctcat cgtatcactg atcccctatt ttttctccaa agccgctcac actgcttatc 3731881 agtgtcccct atcattcgcc atttatttgt gaaagcatgt ccctatttgt cggaatatgt 3731941 tacacgtgaa acataaaaac ccctccagac ggagaggttt gctttagttt ttattaaagc 3732001 ccttttcttt cacgtagtca tttaaatacg tacgcggctt ttgcttcata aagttcagta 3732061 tttgatcgga ccacgtttct tcccgcttcc cgtttgttct ttctctatag taatcagaaa 3732121 tggttttgtc atacgtattc atagtatgac ggaaatcgtc tgtgttcaca ttatacgtat 3732181 tttcatgata aacggcctgc tttggcaatc tcggtttttt gccggaaagg ttcgcaggat 3732241 ggcctactgc cagtccgaaa agcgggagca catggtcagg cgtttgcagc acctctgtca 3732301 ccttgtccaa ttcattccga atgccgccga tatagcaaat gccaagcccc atggattcag 3732361 cggcaatgct catattttgc gctgccagcg ccgcatcaat caagctaacc ataaacattt 3732421 ctgtattctc gagcagctca gaaatatgtt cacctttttc ctcagccagt tgttgatggc 3732481 ggtacaaatc cgcacaaaat acaaaaaagt gtccgttctt ctcaacgtaa ggctgattcc 3732541 cagcaagcac ggacagctca cgttttttct caggatcaga aaccccgata atcgaatatg 3732601 cctgcacata gctggatgta gacgcagcct gcgcactttt cactaatgta tcaatttctt 3732661 cagctgtcaa aagctgatca gtaaaagacc ggattgaccg atgattcaaa atggtttcga 3732721 ttgtgttatt catcacaaaa acctccttat cactttttat catatccgaa aaaaagtgat 3732781 ctcaaaagtg aaatgctctg cacaaaaaaa gacagcctct gtaaaggctg tctgcatatc 3732841 aagaattaaa aagataactt ctgtatttcg tcagctgcac acttgcatta tatacaatcc 3732901 caaatccgat taacgtggaa agtgtcgagc ttcccccata gctgacaaac agcagcggaa 3732961 tcccggtaac aggcataatg ccaatgttca ttccgatatt ctggaatgtg tggatcacaa 3733021 ttaacgccgt atagccaacg caaaagaaag aagcgaaacg gttaaacgga tgtattttgt 3733081 ctatcagaac aacaagcctg tagattaaaa agaagaacat gatgacaaca attgcacagc 3733141 ctataaagcc aaatgactca cctattatag aaaagataaa gtcagtcgta ctctctggaa 3733201 cataaacctt caaattagaa ataccattac ctaaaatacc accagatcct attgccatga 3733261 tggcctggtc aacttgccag ctgtcatttg aatcttcctg tgtctcattt gaagcagaca 3733321 cccaagaagt gacccgctta atttgataat cctgtattcc aactgattta gcaacgtcag 3733381 gaaagtttat cattactaat aaaattaatg aaatgagtaa gatacctgaa ccagctatga 3733441 tcgcaatcaa tttccaattt atccctgaca taaaaaccat tacaagaacg ataaacatac 3733501 atattcccgc agtcccagca tcctgcatca ggataagacc tacaggaata actgcgacac 3733561 ccgcaatctt taataacaag tggatatcat ccctaagcgt ccgaactcct ttaggatttg 3733621 cttttccaat aactgaagca agcatcataa tcaaaccaac cttcataaac tctgacggct 3733681 gtattgttat tctaccgatc ctaaaccaac tttttgcccc tttaataaca ggtgcaatag 3733741 actcgggact gattttaaga ataatcaaag ataaaatacc aatgataaaa atatataaac 3733801 ttaacttttc aagctgttct aaatcaaagt acaaaagaac tgtaatggct acagccccca 3733861 aaagataaaa cacaatttgc tgaatccaat ccgtgttccc atactgccca aactgaccgg 3733921 cagcatatat tgatactacg cttataataa aaaacacacc aaatataaaa atcaaatccc 3733981 cctggtaaaa ggggctttgc tgtttcttat atcgactcat tctatcccgc cttacatttt 3734041 catcggaaaa tcactaatgt ttattataca tgaaccacgt tcaagatgac acgtgaagct 3734101 cgcttccttt tatgtttttt cagcatttgc ggcgcttttt cagctacacg aaatatgacg 3734161 tatcataaac cgaaatgttt cgattgacac aaaacttttc aaatgaaaaa aacgccatac 3734221 caatagaatt tgttaaaaaa cgaatgcgat aatgtgttat gttcccaaat aatgtgatac 3734281 ctcatataga aatagctaaa aattcagagc cccatgccca tacattctcc tagcacatta 3734341 aacgaaaaaa taagacgata gatccagtcc atttctgcaa aaacacgtat caatttctgg 3734401 aaaacatggt ataataattg taacagaatg ttcaaaaaac aatcacaaaa cagacacaac 3734461 tcagttcctc tatttcattt ttgtaaacgt tatcacaaaa tgaaaggaga cgggtatgat 3734521 ggacatgttt tttgcttact tattggttgc cagcgcaacg cctctcttta tttggcttga 3734581 taacaaaaaa gtcgcactct cagctattcc gccaatcatt ttaatgtggg tattcttctt 3734641 cttttacgca acagaaagcc tttctccact tggacacact ctcatgatta tcttgtttgc 3734701 cgttaacgtc attgtcgctc atatcgccgc atttatcatt tacggccttc cgtatcttcg 3734761 cagaaagcga agcagctgaa gacagcaaaa aaccctcttc cactgaagag ggttttttgt 3734821 attattcgtt atggcctgaa tgctctgagt gttcagcgcc tccaggagga tttccgtcca 3734881 tatggtcacc atggtgatag tgagccgcga aaatccagat ggatccaagt acgataacga 3734941 tcgcgccaaa gaatccgaac agcgtgtttc cgacttggat cgtgccgttt tcgctctctg 3735001 tcatatgcat gaacatgaga agctgcagcg ccgcctgaat gaaggcgaag ccgaagataa 3735061 tccaaagttt tgctgatgag ctcaggtcag tatacactgc aacccataga gccagcaggg 3735121 tcaaaacgat agacaggata aaacctacaa tgtgtttcca tggaaagtga ctgtgttcag 3735181 cagatttgtt tgccatttta cagacccccc aatcccatga gatagacacc tgtaaagatg 3735241 aaaatccata caacatctaa gaagtgccag tacaagcttg agataaagat tttagatgaa 3735301 gtttgcggag ttaagccgcg tttcttcaac tgaatcagaa ttcctgtgat ccagaaaatc 3735361 ccgattgtta cgtgagttcc gtgagttcca agtaaaacaa agaatccaga ccagaacgca 3735421 cttgtactga gagccgctcc ttcatgtaca tagtgaacaa actcgttgat ctcgcatccg 3735481 acgaagccgg caccgagaag aagagtgata attgtccaaa tgactacgcc ttttaaactt 3735541 ccgcggcgca tttcatgaac agcgatcccg caggtaaagc tgctgatcag cagcaagaac 3735601 gtcataatca ttaccagatt gacttcaaat agttcgtctg gcaagacacc tccagctgtt 3735661 ctgtttttaa gaacgaagaa ggttgcaaat agtgttgaga acaacacaat ttctgcccct 3735721 aaaaagatcc aaaacccgag aatattaagt ctgccggttt cagattgata ttccataggc 3735781 gcgttagaat tgccgtgttc tgcatgttcc ataactcacg cctccttatt cggaaatctt 3735841 tctttccgtc tcttttattt catcaacact aatgtagtag ccgttgtcgt attcgaatga 3735901 acgcagaacc atgcagagca ggactccgat caatccgact acgcccatcc agtaccattc 3735961 aaagacaagt ccaaagcctg cgagaccgaa ggcaacagac ataaagaacg gtctgcctga 3736021 gttgcttggc atatggattt tcttgaattt gctttcaggg tataattcag ttttttcttc 3736081 tttcatatgc aggaatgcat cttgagattt gacttcagga agcaccgcaa agttgtaatg 3736141 cggcggaatc gcagaagaag tcgcccaatc aagcgtacgt cccacacccc atgaatctcc 3736201 gctgatttca cgagtagagt aacggaagct gtagtagatg ttatagcaaa ggattaagaa 3736261 tcctacaccc atcatgaaag ctccgactgt tgagataaag ttcaatgttg tccagccgtc 3736321 attcggtccg tatgtgtaaa tacggcgcgg catgccttga agccccaaga aatattgcgg 3736381 gaagaaacaa atattgaacc cgatcataaa gatccagaag aaccattttc cgattctttc 3736441 gttcagcttg tggccgaaca tttttggata ccagaaaata aatccggcga aacaagcaaa 3736501 tacagtaccc gcaatcagca catagtggaa gtgagataca aggaagtacg tattatggta 3736561 ttgataatcc gctgctgcca tcgcaagcat aacccctgta accccgccga taacgaagtt 3736621 aggaatgaac gcaagcgccc acagcatagg tgttgtaaag ctgattcggc ctttatacat 3736681 tgtaaagagc cagttaaaga ttttaacccc ggttgggatt gagattgcca ttgtcgtaat 3736741 tgagaagaat gagttaacgg acgcactgtt ccccattgtg aagaagtggt gagtccaaac 3736801 taagaaactc aatacagaga tggcgataat agaaccaacc atcgctttgt aaccaaacaa 3736861 ttgttttctt gcaaagcttg agatgatttc tgagaaaata ccaaacgccg gaagaataac 3736921 gatatatact tcaggatgtc cccaaatcca gaacaagtta gcccaaagca tcggcatacc 3736981 gcctgcttcc aatgtgaaaa agtgagcgcc gaacaaacga tcaaatgata aaagtgctaa 3737041 tgctactgta agtacaggga acgcaaacac gataataacc attgtgatca gtgttgtcca 3737101 tgtgaacatc ggcatacgca ttaatgtcat gccttttgtt ctcattttta agattgttac 3737161 cataaagttg atccctgtca tcagggtacc gataccggca atctgaagtc cgaggaggta 3737221 gtagttctca cccggcccag ggctcatgtc gttacttgca agcggcatat aactcgtcca 3737281 gcctgcgttc ggagaacctc cgataacgaa agaaatattg aaaagcatcg cccctacaaa 3737341 gaacgtccag aagctcaggt tgttcaagta agggaacgca acgtcgcggg caccgatttg 3737401 aagaggcaca acaacgttga taagaccgat taagaacggc atcgccatga agatgatcat 3737461 gattgtaccg tgagttgtaa aaatttcatt atagtggttt gagtctaaaa aactgttatt 3737521 cggaagcgct agctgggcac gcatcatcag accgtcgaca ccgccacgga ataacataat 3737581 tacagcagat ataatataca tgattccgag ttttttatgg tcaacagtag ttatccattc 3737641 agaccacagc catttccact ttttgaagta agtcagaaca aaaataatgg caatggttga 3737701 aagcgcaatg gaaacttgtg cgcccagaat taatgggtca ccagttacga aaaattcgtc 3737761 ccatttgaat ttcatgcagg cttcctcctt tcctgatcaa tatcattctt ctgtatcatc 3737821 agacttctta aattcgtttt tctttacgtt ttcaaacgga tctgttttag aatgcggtga 3737881 aacggcttga tagccaaggc gtttgcgcgc ctccatcgcg tactcagcgt cttgtccgtg 3737941 atcaacgtat ttcaagtgag tagaagagaa cgttaattcg tccacatttt caggaagcat 3738001 caattcatca tacttctctt ttgtcagctt aggagcctcg ttctgagtct ttttcaccca 3738061 gctgttaaag tctttttctg tgactgcatt cacatcaaac tcttggtctg caaaatgttc 3738121 acctgtgaag ttcgcgttgc ggccttcgta agtacccact ttgtcagcct gtaagtattg 3738181 atccatcagc attcctgcca tcgcatattt ttgccctcca agctgaggaa tccatagcga 3738241 agccattgaa tctgcagatg agattttgaa caagatcggg cggtcgacag gaatgtttaa 3738301 gtagttgacc gtttcaatat cctgttcagg gtagctaaat acccatttcc agtctaccga 3738361 agtagcataa acaacaagag gctctttgtc ttttgttgct tcaggagctt tttctaacga 3738421 atatatcgtc tgtactgttg gcacagaaag tgcaatgacg attaaaattg ggatcactgt 3738481 ccagactact tctaaaaacg tgttaccgtg aatttctggg ttataagatc cattatcttt 3738541 gcctttacgg tcgcggtatt ttactaaaat aatggtaaat agaacaaaga cgaccccgac 3738601 gataaacagc ataaatccga tagataacag gattaaatca ctttgctgtt cagctacagg 3738661 tcctttcgga tctagtactg aagcattgct gcatccccca aggacgaaaa ccacagttaa 3738721 cagcgctaat acaagcaacg gttttaatgc tctgaacaag aagatcacca tccttcctat 3738781 tgatgtaata aatctgaagt gcatacttcc tcaaaatctt ttctctactt tgttatgcta 3738841 tcaaaaactt cacttattag ctttattttt ttataaactt catcccattt tcgcttaaat 3738901 gtcataaaat cgacaaaaat tgctccaact ttattcacat ctatcgctta agatgaaaag 3738961 tttctagtta tttccgcata taaagtaaag aaagatgatg aagaactaat tctgacaaat 3739021 taaggtttac cacaataaaa aacttaggtc aatcaaaaat ttcattttgt taaactttct 3739081 agataggaat tattttttcc tcgtctagca tcttttcaca cggttaccat tttaacgcat 3739141 caaatattga aagaaaaggc gcaatgaaga gccaatatgc tctgaattgt ccgtattttt 3739201 ttatgagagc atccagttgt ttatcttata caaaaaagag gaatgatata agcaaataaa 3739261 taaaaaatag gatgtgttgc atgatgagtt ttcttatttc acttatcgtc gctattatta 3739321 tcggatggct tggaagcctg tttgtaaaag gagatatgcc cggaggaatt atcgggtcta 3739381 tgatcgcagg tcttataggc gcctggatcg gacacgggct gcttggaaca tgggggccgc 3739441 acctagccgg atttgccatt attccagcgg taatcggcgc agccattgtt gtctttctag 3739501 taagcctgtt aaccagaaaa agaggataaa agcagcagca cccgaagcgt cagcgctttg 3739561 ggtgtttgtt ttgccataaa aatcgaaaaa gcctcaaccc tagcggttga ggcttttgac 3739621 tggtttggcg cccaactgat cgatgaacct tctgaaggcc tgttttccct ctgctgtctg 3739681 cttaaataca ccggcgtgtt caaggatgcg cgcgaataca tgtcccagct cttcttttat 3739741 gactagatct acgttctctt ttgttatggt tcttttttcc atcgtccgaa gagcccactc 3739801 actatgcttt gcagtgagcg gattttgttc taaggctgtt ttcggatcag cagaacatag 3739861 cgccgctgcc gtttctttca tttcctcctg taagcggcca ggcaatatcg ccaatcccat 3739921 gacctcaatc aggccgatat tttctttttt aatatggtgg acttcttgat gaggatgaaa 3739981 tattcctaat ggatgctcct catccgtccg gttgttcctc agtacgatat cgagttcgta 3740041 caagtctccc ctgcgccgcg caatcggtgt gaccgtatta tggggcgtat cgcctgtata 3740101 ggcggcaatg ccggcttttt catcggaata cgtctgccac gtgcggaaga tatggtcagc 3740161 agcttcggcg acatgacccg gttcgtctcc ttggagcctg agcacagaca tcggccactt 3740221 cactaagccc agcgacacgc cgggataatc atttaattca taaacgtctt ccgcttctgc 3740281 acgtgccatt ggaaaatcat gcgcgccgcc ttggaaatga tcatggctta ggatgctgcc 3740341 gccgacaatc ggcagatccg cgtttgaacc gataaaataa tgcggatatt ggccaagaaa 3740401 tgacagcagc ctttcaaatg tttttttgct gatctccatc ggttcatgtt caccttttaa 3740461 gacaatgcag tgctccggat aatagacata tggcgagaat tgcaggaacc attgttcgtc 3740521 ctcaaggatg accggaatga ttctgtgatt ttgccgggct ggatgattca cgcttccctc 3740581 gaagccgaca ttttctttac acagcaaaca catcggataa tttgtctgtt cctgctcttt 3740641 tgcagccgca atcgctttcg ggtccttttc aggctttgat aggttaatgg tcatttccag 3740701 ctcgccatat tcggtcggca ccgtccaatg aacatttttg gcgattctgt cagtccgtat 3740761 ataatagaca tcctctgaat attgatagaa ttcctttgtc gcctgttttg ggccgtataa 3740821 tgcttttgtc tcttcaaatt tgcgaatgac ctcggacggg gcaggcacaa aacagcccat 3740881 cagctttgcg ctgagcaggt cacggtacgt atctgtatcc gcttccattc ggccggtttc 3740941 ggcagcccat ttatagatgg gagctagcaa gtccggcagg ctttgtgact gcttgatgct 3741001 ggtgctggag ttcggctcgg gatgtgtgat gcccagcgct tcataaagac ggtttctcgt 3741061 atattcccga tcccagatcg aaatcaattt tcgttccagg ccatactcaa gcagctgttc 3741121 cagatgttca ataatactca tatgtcactc cccctttagt tctctcgctc cctctccgat 3741181 atccgcgaca taaaagtccg ctcggagccc tgttttttct tgatatctgt ctccaacctt 3741241 ctgaataaaa tcatcaacga actcatcttt tacaatgctg atggtgcagc cgccaaagcc 3741301 tgctcccgtc attcttgatc caattacacc ttcgtgatcc catgccgcaa acacaagctc 3741361 atcaagttca gggcatgtta cttcatagtc atccttcaat gaaaggtggg attccttcat 3741421 taactgcccg atttcatcta tattgttctc tttgaacata tgggccgtct taatagcacg 3741481 atgattttcg tatacagcgt gctttgcccg gcgtctgttc gtttcatttt ggatcaggct 3741541 ggaatgcgca tcgaaatcag aaggcttgat gtcgcccagt gcggcaatat cgaggccttt 3741601 tttcagatca agcaatgcat cattgcattc ttggcgtctc gtattatagc tggagtcagc 3741661 caatgtcctt tttttgttcg tgttcgcgat gaccagcgcg aggcctgaga cattgagttt 3741721 gctatattca tagtcaagcg tgtcacagtt cagcagcatc gcatgatgtt ttttccccat 3741781 tccaattgca aattggtcca taattccgca attgacgccg ataaaatggt tttccgcatg 3741841 ctgcgccatt ttcacaagct caagcgcatc tacttcagga tgaaaataac tttggagcac 3741901 gacccccatc agcagttcaa tagaagcgga agacgacagt cccgccccgt ttggaatatt 3741961 ccctgaaaat acaatgtcaa agccatgggg aactgcatat cccctctgtt gaaattcata 3742021 aatcacgcct tttgggtagt tcgcccagtc gtcttctttt tgatagcgaa tgtcgtcaag 3742081 gctgcattcc ttgatgcctg cgtttctaaa gttatctgaa tacatccgga caagcccgtc 3742141 gtttctttct gcaacagcag catatgtacc cattgtcagc gcgcacggaa agacatgccc 3742201 gccgttatag tctgtatgtt ctccaatcag attcactctt ccaggtgcga aaaaaaaccg 3742261 taacccctct ttttctccga atacacttgc aaatatcccc tttagctctt cccgcatgtg 3742321 caatcacctt tctggttttt attttttatt ccccttattt cttcatagaa aacggcagat 3742381 catatgctgc agtcctctca taccccttct tcttttgttt ttttaaagac gagccatttg 3742441 ctcgcaacat agttgacgac aacaatgacc gcgttgtcga gtattttggc caaggtttca 3742501 tttgtattga actggccgac aagaatgatc atcatgccta aatctatgcc gagagacagg 3742561 acccgaacgc tgaaaaaagc agtgagctct ttcagcaggc tctgcagatc atgtgttttt 3742621 tgctgaaaca catataattt atttgttatg taagcaaaca gcacggacaa aatccaagcg 3742681 gcaacagtgg cggctttgta atccacattc atgatctcta ccaatatata aaagctggcg 3742741 atattcacaa tggttgtgaa aacccccata atgatataca taattatttc tctatacttc 3742801 actgatgttc ctcgctttct gaaaaacttt tcaaaattct tggcctctcg tgctctctgt 3742861 ctaaagtaaa aaataccgag agtgcgtcta aaaagctgcg gaaggtggct ggctggccca 3742921 atacatatga ttgtttgatg attccgtcga ggactgcaca tattatttta gccgtatatt 3742981 caggatcaat acaggcgtca atcagctttc tctccttcag ccacttaata tataacacat 3743041 tttcttccac ccacaattcg tacagccgga cataggcctt gcatttcttt aagactttat 3743101 atgtcggcat gttcatggca aacgaggtga tgtcccacga cggcttattt atgtaatagg 3743161 aataaagcag ttctgcagcg tgttttgcag cctcgtccaa tgtcagcgat ttcactgact 3743221 cccgctccat ttgatcaaga taccctataa tgatcttttt tttcatctga cgtttttcga 3743281 gaaggtacag cagaaaatcg tccttgctga caaaatgaac ataaaatgct cctttgctgt 3743341 acccggcggc tctgctgata tcttctacag aaaccggatc atacgctcgg tcaatcaaca 3743401 aattcacgcc agcgtctata aaactttcaa atgttgcttc tcttttaatt tgaaatttgt 3743461 tttttttcat atttttctcc tggcggtaat gattaccctt atcttacacc ggatcaatct 3743521 ttagcggtat ttatttcttt aaacggttat gctattcggt ttcccagggg tcatttttaa 3743581 taggctaaat gatttatttt catttacata ctatccagtc agtatttaat tgtttattat 3743641 tataaataag gtccattggt tatattagtc atttttttag ggaataggta ggtggttttt 3743701 ccttcagttt gtgaacaccg agcaactatg tgtgaaattt gttgtactcg cctccatcat 3743761 cgcgctggct tgtcttttat tgcccgcatg ttgcaggaaa acattttata caattggagg 3743821 ttactatgaa aactcatgtt aaaaaagatt tggacaaagg ttggcatatg ttaattcaag 3743881 aagctagatc cattggatta ggcattcatg atgtgaggca gtttttagaa tctgagacag 3743941 catcaagaaa gaaaaaccac aaaaaaaccg tccggcaaga ctagtccgaa caggcggatc 3744001 tatttacctc tggcttttct atcacctgat ctgagttttc accatatcct ctattcaaaa 3744061 gcaaatcgct gcgctgagct tgaggacaaa cggtgtgtca gctaactacg acagacagcc 3744121 ggtgatgcga tcacctcttg gcacatgcat tgtcataaag aggtgatgcg aacatgataa 3744181 ccgtgctctg gtaaacagca gctttgctga gaacaagctg cattcggtga ggttttgaaa 3744241 gcaaactcgt ttatacacgg ccgagcttga aaaccttcgc ctgtctttag accactgtgt 3744301 tcacctcttc acgacttcct tcttttttca tcctccagct attgtacaac gcataaatcg 3744361 gactttcagt acatacctat tggtgtacct ttttgcttac gtttagcgaa taaaaggagg 3744421 aaagccatgt acaaagctga ttataaacag attgctgcaa cgccgtcttt tcaagctttt 3744481 ttaaagcaga aacgcgcttt tattgttcct tctgcgattt tcttttttgt tttttatttt 3744541 tcactccctg ttttgacatc ttatttcacc tttttgaatg caccggccat tggagctgtt 3744601 tcatgggctt ggctgttcgc catcgcccaa ttcgctatga cctggatact gagtactgtg 3744661 tattcccgga gagccgccca tttcgataag tatgtaagcg ctttaaaaga ggatctgaag 3744721 ggtgaacaga catgaatatg actgcttttt tattattttt ggcgattgtt ggcctgacgc 3744781 ttattatcac gtattttgcc gcgaagcgga cgaaaacgac gagtgagttt tatacggcgg 3744841 gcggcgggct caccggcgtt cagaatggac tggcaattgc cggtgactac atgtctgccg 3744901 cctcgtttct cgggattgcc ggaatgattg cgttatatgg atttgatggc ttcttttaca 3744961 gcatcggttt tctggtggct tatctcgttg tcttgtacat cgtggcggag ccgcttcgga 3745021 atcttggaaa gtacacgatg gcagacatga ttgccgctcg ctttaaagaa aagaaaatcc 3745081 gcggtgtcgc ggctctcaat accattgcca tctctacttt ttatatgatc gcccagctcg 3745141 tgggggcggg cgcgctgatc aaactgcttc tagggctgga ttataccgcg gctgtcctca 3745201 tcgtcggagt gctgatgacc atttatgtcg tgtttggcgg catgatcgcg acaagctggg 3745261 ttcaaattat taaagctgtt ttgctgatgg ccggcacact cgtgatttcg attatcgtgt 3745321 tttcgaaatt cggctttagc cttaatacca tgtttgaaca gatgaaaacg gctactccgc 3745381 ttggcgctga ttttttgaac cccggaaata aatacaaggt gccgcttgag accttgtcgt 3745441 taaacttggc actcgtgctg ggaaccgccg ggcttccgca tatattgatc cggttttata 3745501 ccgttaagga tgccaagacg gcccgtacat ccgttgtgtc agcgacatgg attatcggtg 3745561 tgttttacat tatgacggta tttctcggct ttggtgccgc ggcatttgtc ggttttgacg 3745621 cgattacggc ggctgatcaa gcgggaaata tggcggctcc gcttttagca aaagcgctcg 3745681 gaggagactt tctgttcgcg tttgtatcag ccatcgcctt tgccaccatt ttggctgtcg 3745741 tgacagggtt ggtgctgtct gccgcctcag catttgccca tgatatttac agccagatca 3745801 tcagaaaggg agaagcaact gaaaaagaac aaatgaaagc ggccagatgg gcttctgtcg 3745861 ccgtgtcagt gctctcgatt ctccttgcga tttttgcaca atccttaaat gtggcgttcc 3745921 ttgttgcact cgcgtttgcg gtagccgcca gcgcaaacct tccgctgatt gtgtttacag 3745981 tcttctggaa acgattcaat gcctcaggcg ctttatgggg cagcctgaca ggcctgatca 3746041 gcgcgcttgt gctggtatcg atgagcccta gtgtgtggga cccggccgga ggtgctattt 3746101 ttaccggtga tccgctcatt ccgctatcta atccaggaat tatttccatc ccgctcggct 3746161 ttctcggcgc gtggctcgga acggtgctgt cgtctgataa aacaattgat gaagatacgt 3746221 ttgcagaaat tcaggtgaag gcgcatactg gcgtccatat ggaacaggaa taaaaaaagc 3746281 tctctttatc gagagctttt tccttacttt ttcttctgct cgtcagaaat cgctttttca 3746341 aatacatcct tgccggcagc acccggaatt acagtgtcac cgataataaa ggttggaacg 3746401 gctgtgatgt cagcctcttc ataggcgtgc ttcaaggctt ggcgctgcac gtcctgatat 3746461 gttcttgttt ccagtgctga tttgaatgat gcaccgtcta atcccacttc ctcggcgagc 3746521 ttcgtcaaga tgtcaatatc gccgatattt tggtcctcct ggaaaaatgc ctgaaagaca 3746581 cgggtgttgt attcatgtcc tttattgtat tccttcgcaa aatggaagcc ttcaaacgcg 3746641 aggtctgtat acggatgggg cgagacgttt ggaaaattga tctcgactcc taatttctcc 3746701 gccattggct gaattgatgt ctgccacatg tactgtttag aaggatcatt gaccggatca 3746761 agctgaggag atgggcttgg gcgcagttca aacggcatcc actcgacttc aacatccttt 3746821 ccttttatcg cttcttcaaa agcggctttt ccaacaaaac aaaatgggca gacgtaatct 3746881 gaataaactt taatgtgtac tgtcatgata atctcctttc atactaaatt gattttaaac 3746941 tgtaacaatt aaagttacaa ctgtttttta ataaagaagc cgatttaggc ttctttcaga 3747001 ttgatgacaa aatcctaaaa agttttagga ttttgtcatc ctttcagcgt gattgaaaac 3747061 ccttgaagtc taggaaagcc gagcattgga gcggagcgaa tgctctaatt cgtgagcacc 3747121 aacgcacagg cttgacaacg aatgcgaggg tttgtcgaca cgctgaaaga agcctgtaaa 3747181 ggcttctttt atgattccag caaacgctgg gcaatatatt ctcctttttt gcagccgcct 3747241 gggcatgcgt ataaagcaga accgattgtt tgtgtatatt cgtttaacgc atcctttgct 3747301 gaaagagcct tcagcatcgg gataaactga ttgtcgggat ttttttgaaa actgataaac 3747361 aggagacctg catccatata gccggttttc ggatcaagtc cttctgtgta agagaaagct 3747421 cttcgcaaaa tttgtttccc agtagatttc gctagactga cgtgtgaatt agacggaatt 3747481 tgattcagct tcacgggatc tgtttccttt ttctgcccaa aaggcgcccc cgagcttttt 3747541 ctgcggccga aggtatcctc ttggtccttg agggaagagc ggtcccatac ctcaaggaac 3747601 attttgattt tccgaaaagc catataggtg ccgcccgtca tccagtcagg ctcaccagac 3747661 tgaatccaca cgatcgagtt catcaacgtg tcatccttcg tgctctggtt gcctgttcca 3747721 tctttaaacc cgaagaggtt gcgcggtgtt tcaccatttt ttccaccgct taaaaagcct 3747781 ttgttcacaa aacggacctc acaagtgccg accgcttgat ttagcaggtt acgcagcgcg 3747841 tgaaacgcca cttgctcgtc gtctgcacac acttgaatgc agatgtcccc gcctccctgc 3747901 ttttcatcca ggttgtcatt gggcatcgct ggaagagcgg ctaggtgctt cggttttttg 3747961 cttttcagtc cgaagcggtc ctttccgtct ttttcaaaaa agccaggccc gaatccgaat 3748021 gtgaccgtta agttggaagg ggataaatca gcagactcac ctgtatcctg cggcggcaga 3748081 tactgatttc tctgctccgc tgacattttc ttgccagacg tcagcatctg tgtgagactt 3748141 gtccagtttc taaataacgt aatgatgtcg cttttgtctt ttgctgttac atccagtgca 3748201 gcaaaataga catacgtctg atgggcagtt gtgattccgg cctgatgctt tccgtaaaac 3748261 ggaacaatct gctcctcctc tttttcatcc tttttcgatg gcttagccgc agtctgaaca 3748321 agcggagcga gaccgccgag accgctggca ccgatcgcaa cggctgcccc cgccatcgct 3748381 ccccatttta aaatgtcccg tctgtgaatt tgttctggct ttttctgttc atcgctcatg 3748441 atgttacaaa actcctttta tagcacattc gcaatcttcg acatggtttc agaaagagtc 3748501 gtcagcttag tgctcagctc tctgatttgc ttttcactta atttatcata agacgtatag 3748561 gactgatcat ttgttttgta ttttgccatt aaaacttcaa attcgctgaa ctccgtatcc 3748621 agtttttccg tcaagtcgga gtgatctttt acaagcgcgc ttttcactgt ttgataaacg 3748681 gcttcggagc cttccacatt tgccataagg tcaactaaat caattcgtga gtagcgctct 3748741 tcttctcccg tgattttcga aattccggct tcgttcagaa gctccatcgc gcctgcaaca 3748801 atttgttcag gtgttaattt cagtgattga attgaaccgt caagctcttt tacatccttg 3748861 agaagctggt cagctgttgc cttttccccg gaaatatctt gatccttcca aatggccttc 3748921 tcaagcttat ggaagcctgt ccatttgtct ccttcttcaa catcgttttc tcgtgcgtca 3748981 attttcggat caagatctcc gaggctttca gcgatcggtt cgattcgctc gtaataaaca 3749041 cgcgctttcg catataacgt tttggacttt tcgatatcgc cggatttcac agcacccgta 3749101 aatgcttcag tcgctttgac aagctggtca ctctgctctt tgacatagcc tttatactca 3749161 tccgctgctt ttgccagctg atcgctagcc tttttgccgc tcttcttcgc ttctgtcagg 3749221 tcttctaagg atgctttcaa tgactcggat tctgtcttga tttttcctgc atccggtttg 3749281 tctttttgcg cttctgtgta gattggctga agatgctttt cgatttctgt atattcgaat 3749341 ggatagtcgc tgcgaatatc gttttcaaag gaaagccagt agctgtttaa ctctttcccc 3749401 ttcttttcaa tctctttttg gtctcctttt tccactgagt cattcagctt agaaatgatg 3749461 gtttccattt tatttacgga tgcggtgatt tctttagtga ccccgctttt ttcagatgaa 3749521 gctttttctt tggttgaaga tgtgtcattg gctccgcagc ctgcgcacag cgcaaggatg 3749581 catccggctg atacagcgat ttttgtgaaa ttcattttgt cagttccttt ccgtttgtaa 3749641 aatgttttgc cgcttctgaa acaagcgcaa tcagtaaaaa gagtaaaatc aacatttgcg 3749701 gaatcgtgct gtacacagac ggataaattc ctagcaccga tacagacggc agccagcttt 3749761 ctgcatcaga cggaagaatg cccgccagtt gaaggctgtg aacgccggtt ccgagaaatt 3749821 tcacgcacat atacaggaca accgccattg atagaagaaa aaacggcttc aatggaatgc 3749881 gcattccgag cttgatcatc agaacaccga cgatgacgag aacgataagc cctgcggcag 3749941 ttccgccgat cagttcagtg agcgggagct tcccgacaag cccgatgaaa aagatgaccg 3750001 tttcgagacc ttctcttaca actgccagaa atgcaatgag cgcaaaggaa agcaggcttc 3750061 gtttttttag tgcctgtgac ttctggatat tgattttttc tctccattta tccattgagg 3750121 cgtttctgtg cagccacacc ccgacataca aaagcatgac agcggacagt acgccggtaa 3750181 cgccgccaag caagaaattg ttttctccga atacactgga ggagaacaga accgtgacac 3750241 cgatgccggc tgctaaggaa acagccatgc cggcggacgc cccgccccag atccatgtcg 3750301 aggaacgcgt aacccgcgct ttttttgtca tggttaatag cgctccgatg acaaggaggg 3750361 cctccattcc ttcacgaacc gggatcagcg ccgcatccca ccagctgtag ctgcttgaag 3750421 cgatcggctc gagcaattga atcatttcgt caatttgctt tgataccttt tcaggatggc 3750481 tgccgatctc cgccttcatc agcgccagat tttcctccga tgtcgtatag gcttctttcg 3750541 attgggacac gacatctccc tcaacagcga gccaggatgt aactaaattg tcgattgcgg 3750601 atgacgcttc atccaattgt tttttttcta tgaactgttt tgtgtctttc aagctttgta 3750661 tataggctgt taaggacgcc cttgattgac ctgaggatgt ctttttcagc acgacagcct 3750721 gctgataggt ttctaaatga gacgcaagct cttcaagctg tgttttgagc ttacgtgcgt 3750781 cttgattgat aaaagaaaga gaaatcatcg cgatattcgc gtccatttca ctgtgagaag 3750841 aaaggttttc tttcttaata gaaggttctt cttttttcca cttcgccttg aaggtgtcaa 3750901 acgtttgttg tgccgaatcc atatccccgt cttttacgga tttgatcatt tgcttgttta 3750961 attgaattaa tgcggcgatc ggatcatctt ccgcatgtgc cgcagaaccg aaaaccatca 3751021 acaagctgaa tagaataagt gccagccccc gagccatcat gttcctccta taattgaaaa 3751081 tgattatcat tgtataacat aatcatagcc agttcctgtc ctttgtcaat taaaatttga 3751141 aggtctgaaa accttgatgg acagcaaaaa agctgtcctt ttacagaaca gccctttgaa 3751201 ggaaaatgaa cgattatctt cctgttttat acgtttgaat ttcctcacga aacttgcgtg 3751261 cagcactctc aggatcctcc gcctgactga tggcgctgat catactgacg ccatcggccc 3751321 ccgcttggat aacaggtgcg gcattatcta ttgtgattcc gccgatgccg acaattggaa 3751381 tgctgatgcc ttggcggcgc actgcttcga taagagatac accctgtacc gctctcgtat 3751441 cttttttcgt ttcagtcgga tagatcggcc caagcccgac ataatccgct ccgtcttctt 3751501 cggcttgctt cacctcagac atcgtatggg cagaaacgcc gagaatcata tcacctatgg 3751561 cagctcttac ctctttcgca tttgcgtctt cctggccgat gtggatacca tcagctttca 3751621 gattcagagc caattccaca tcatcattga caatgaacgg aacaccagct tcacggcaag 3751681 ctgcctgcgc tttttcagca aatttaatcc gagcctctcc tgtcagcgca tccccgcctt 3751741 tttcacggaa ctggtacagg gtggcaccgc cttttaacgc tttttgtaca actgtaacag 3751801 gatcggcttt cgtattgttt gaccccataa tgaagtatac agataataac tctttcatca 3751861 tttcccgaga aatacgagtc atgagacagt caccctttct atagtcgccc attcttggac 3751921 gtcttgttca gtaacagttg aaagcttgtt cagcaattca atctgaaagc ttccagggcc 3751981 tttgtcagcc gtctgctgtg cggcaagctg agcggcgacc ccatacgaag aaatggccgc 3752041 aatagcagca aacaatggat tttcttccac agcgcaaaac gcaccgacga cggaagtcag 3752101 caggcaaccg gcgcctgtca cttttgtcag cagcttgtgg ccgttatgaa gggtgtatac 3752161 atgtgacgtg tcggctatga catcaacttc accagttatc gcaatgaccg tgtttagctt 3752221 ttgtgccgcc tgctgagcca gccggatgat gtcgcctcca ccttcacccg catcaacacc 3752281 tttgatcagc caatcggtca cgccgacggt atgggcaatt tccgccgcat ttcctctgat 3752341 tgcagcaagg cgcacctcac gaatgatgtc acgtgccgat tcagtgcgga acggtgttgc 3752401 tccggcaccg acaggatcaa gaatgacggg aacgccatgt tcattagctg attttcccgc 3752461 gatgatcatc gcttcgactg actccttgct cagtgttccg atatttaaaa cgagtgcacc 3752521 cgcaattttc gccatatcgg cgacctcttc ttttgcgtac gccataacgg gcgatgcgcc 3752581 gagcgcgagc aggccgtttg ctgtgaaatt cgttacgaca ttgttggtta tgctatgcac 3752641 cagtgggcta tgccggcgga cagccgtaag acattttgct gctgattgtg catccatatt 3752701 tgcatcatcc tttactatct tttttcgggt cccataaata cgatttcgta tgttcgagcc 3752761 aagctctggc ggcaaacgac aagtacctgt cctttctcca aataatggcg aggtgccaag 3752821 ggatgaccgg atcgacaagc ggaatgactt tcactttttc cgggtcaagg ccgcggcaga 3752881 tccgttccgg caaaagcccg atcccaaggt tggcggatac catctcacta ataaaatccc 3752941 attgtgatgt ttcataaatg atatggggcc ggaacccagc cttgatacat tccgtcataa 3753001 ttcggttgtg caggacaaaa tcctctctga agaaaataaa aggctcgtcc ttcaactcac 3753061 gcagctgaca ttctttctca tcagccagcc ggtgggaagg gtgaacgaca agcattaagg 3753121 tttcttttac gattgtaaac gaatgaaaga tatcttcgtt tgcgggaagg accacaacgc 3753181 cgatatcaag agagccgtcc ccgacacctt cttggacttt tatagaaccg tcttcgacta 3753241 gctgaaaggt gacattcgga tagttttcac ggaaatcgcc gagcactctg gggaaaaacc 3753301 ccgatccgat catcggcggc agtccaatcc gtacgtgccc tttcttgact tccataatat 3753361 catttaattc tgacgtcagg ttttgaaatg atttaatgat ttcctgcgcc tgcacataca 3753421 tgctatgacc ggcatcagtc agttccacct gcctgccgtt tcggtaaaac agttcaattc 3753481 cgagctcttc ttctaaattt ttgatcattt ttgatatcgt cggctgagaa acataaaggg 3753541 attgggaagc cttcgtaaaa ctttttaaac gggcgacttc caagaaatat gttaaatggc 3753601 ggatatccat gcgcttcacc ctttctatag acaaaaggaa tacttcttat tcttaatata 3753661 tattttacct atagagagac cttatgtaca ataagtatat aagggaggca tcaatatgaa 3753721 aaaactgttg ctaaccgtta ttcaaatcgc tctgttattt atatttgctc ggctgattaa 3753781 ttgggtgaca gcccttcttc atataaatat tcccggcagt ataataggga ttgtgattct 3753841 tttcacatta ttgcacttta acattatcaa gcttgaatgg atcgagcttg gtgcagcgtg 3753901 gcttctcggg gagctgcttt tattttttat cccgtctgcc gtcggagtga ttgaatacgg 3753961 agacattatg tcgaaatttg gtgtcagcat tctgcttgtt gtcatcatca gcacgtttgt 3754021 cgtgatggtg tctacaggaa cgcttacaca actcatcgca aagagaaagg agaaaaagca 3754081 tacgtgttca tcggaattgt aagtttgttt ttaacggttt tggtgtattt aggagcaaaa 3754141 aaggtatatc aacgctttcc gcgtgtttat acgtcgccgc tattggtgac gcccgctgta 3754201 ttagtcggtc tgctgctgct ggtgaatgtc ccgtacgagt cctataatct cggcggcgga 3754261 ttgctgaccg atatgctaca gccggccacc gtggcattcg cgatcccgtt atataaatat 3754321 ttccctgttt taaagaaata cgcagtggaa attattttga atgtggccgt cggttcatgc 3754381 atcgcgatta tttctaccgc tcttattgcg aaatggcttc acctcggcac cggcttaatt 3754441 gacagcctcg tcccaagatc agtgacaacg ccgatcgcga tgaacgtatc tgaaatgatc 3754501 ggcggtatgc ctgccgtcac agccgtgttt gtgattttaa ccgctttgct cggcacagtg 3754561 atcggcccga tggtcatccg ttatttccgc attgataacg aaattgcgcg gggcgtgctg 3754621 cttggcacaa gcgcgcacgg agcgggaacg tcaaaggcat ttgagctcag ctctgtgtcc 3754681 ggcacgattt ccagcgtgtc gatgatctta gctgcgatta tgacgctttg cgcggcgccg 3754741 tttttgcttt catttatgta aaaaactgtc ctctcgaggg cagttttttt tatgtgcttc 3754801 cccttattga aaagctggcg aattccaata taatgtattt gtggatacca aaggaggcac 3754861 cctgatgcac aacttgcagg tgaggcggca ttatgccgcg ttaaaaggat tttatttgtt 3754921 tgcttttctc ggtacgggca gcataattcc cttactcagt atgtatttaa cgaaggaaca 3754981 gcatttaagc ggatcacagg tcggcttgat catgtcactg ggcccgattg tgatgatttt 3755041 ctttcagccg ttttggggca tgctgagcga ctatacgcaa aaaacgaaag gcctgctggc 3755101 ggtttgcaca tcaatcacag gcatcattgg attagcctat attgcatttg acagtttccc 3755161 tctgtttatt ttgattgcgg cctgttttgc agcctttcaa agcacgatta ttccactttc 3755221 ggacagcatt tcactaaggt acacacaaga aacaaacggc aactacggcg gaatccgcct 3755281 gtttggttct ctcggcttcg gtgtcgcggt gtttgccatg ggacaggtga cgaaccagct 3755341 gtaccccatt cacgtgatct ttatctttgg ctgtgccttt ctgtgcattg ctgccatatt 3755401 ggcttcacaa gtgcccggcc agcagaaaac aacaaaggtc aatatccgca aaggattccg 3755461 ggagcttatc agcaacaaaa ctttcctcat ctttatgatc atcaccttta cgacatttgc 3755521 tccaaactta gcgaacaata cgtatttcag tctttttctg gacaaaagcg gcgcgtcact 3755581 ttccgctatc ggcattttat ttttcatcgg tgtcatttca gaaattccat ttatgagatt 3755641 cgcccaaaca tttatagata aaatggggct gctcaacgtc attatgctgt caggcggagt 3755701 ctcattattc aggtgggcgc tctatttcac ggcgccttca ctatggatca tttatgcgac 3755761 ggtctttctt cagggagtgg ccatcggttt atttatcccg gcggcgcttc aatatgtgaa 3755821 aaagattacc ccaagacacg ttgaagcgac ggcgctgacc atgtacgccg ccattggcaa 3755881 cgggttcggc aactggttct gcacatttgc aggcgggtac atttttgact acgtgtcgat 3755941 cttcgcagtc tacttgcttt ttggcattct gagcatagca ggctttggcc tgacattata 3756001 tttaatgaag gctgaaaaaa acaaacatac acttcatcag ccggctgtta cttttaaacc 3756061 ataatgacta taatgaacaa aagaaaggat gtgcgttatg aacgggcaag agcgaaacag 3756121 catttcgaaa gggttgcagg ttgatattgt attgaaagca gatcaaaaaa caggaaaact 3756181 gacgagaggg acagtgaagg atattttgac gaaatcaaac tttcatccgc atggcattaa 3756241 agtccgtctt gaagatggcc gcatcggccg cgaccagcag atcgtttcta cataaaaaaa 3756301 agctgcccct gaacagggca gctttttcat ttattttttc tgcagaagga ccactttcag 3756361 gtagttgcct tccggaaatg ccgaaatcgt tttgaaatcc tccggcagcg taaattcctc 3756421 aatgatcgtg tagcgttcat ttgtttcttt aaaggcggca tcaataaagc ctttgaactt 3756481 cttcatgcca aaggcgctgc tgtttgtaga ggcaacaatg acacccttgt cagcagtgat 3756541 ggcgatcgtt tccttcagca ggtttttata atccttggcc gcgctgaagg tgcgtttttt 3756601 tgtgcgcgca aaggaaggcg gatctagaat aatcagatca aagcgcaaat ccttttttgc 3756661 agcatatgaa aaatagttaa aaacgtccat cactttaatg tcgtgcgctt cgtaatccag 3756721 cttgttcacg ctgaattgct cgatcgtttt ggcaagactt cgatttgcca cgtcgacgct 3756781 tgttgttttc tccgctccgc caagcgccgc cgccacggag aatgcacccg tataagaaaa 3756841 cgtatttaaa acggttttcc cttttgcata gcggtctctg atcgccttgc gcacatgtct 3756901 ctgatccaaa aagatgcccg tcatggcgcc ttcattcaga tccaccgcgt attgaatgcc 3756961 attctcttgg atgatgatcg ggaactcgcc ccttctccct ttcacgaagt catcatcttc 3757021 aacgtattgt ccagccgtgt cgaagcgttt cttctcgtaa atcgctttat aatcaagatc 3757081 catctcatcc aatgcggaaa tcagcatgtc tttaaaggtg taaattccct tgctgtacca 3757141 ttgaatcagc aggtagccgt cataatagtc gatggtgacg ccgccgacac cgtcaccctc 3757201 accgttgaac aggcggaaag ctgttgtatc ttgagcctca aatagtttgg cgcgcgcttg 3757261 ggccgctttt gttaatttgc tgagaaaaaa tgcttggtca atctgttcat gtttattgcg 3757321 ggtaagcgtc cagccaaccc ctttgttttg caggccgtaa tagccccgcg cgagaaactc 3757381 gccgccgctc tcagacacga tatcaacgag gtctccttct ttcatgtgcc ccgcactccc 3757441 tgcgagagct tctttttcaa taaggggata gccttttttt attttggcag cgtgtgcttt 3757501 ttttagggtg agtagcttca tatatgtcgt cctctttccg tttgctttct cttatggtac 3757561 cacaaaacgc caagatgtct gcattgacag aaaggaaagg tttttctacg atagacaaaa 3757621 agagttacga ggaggagcag catggcaaaa cgaattgacc atacaggcat catggtaaga 3757681 gatattaacg cgtccatcac attttatgaa gaggtactag gcatgaaatt gaaggatcgc 3757741 atcactcaca cgaacggtgt aatcgagctt gcttttcttg gctttgaaga cggcccggaa 3757801 acagaaattg aactgattca aggctacagc agcgagcttc ccgctgaagg aaaagtgcac 3757861 cacattgccc tgctgacgga tgacatcgcg gctgaatata caaaagcgga aaaaatgaac 3757921 gcaaaattta tcgacgagga gatcacaaca cttccaaacg gataccgtta tttctatatc 3757981 gaaggccctg acggtgagtg gattgagttc tttcagcggt aaaaataaag aacgtacatt 3758041 ttgtgatgta cgttcttttt tatctatacc aactgatata cgttgactca tcgcaaatca 3758101 tagcttccca gcccatacgc tcaaccaatt catggatgtt tttatctttg gctaaaaaga 3758161 cattaatgaa tgagtcatat acactcataa acacaaaatc cattttctca tcagttaaaa 3758221 cgagctctgt tgcggcttca tcaagaaccg tccgcaagtt ggcttcagtt atgtccaaaa 3758281 cgccgcggtt ttccacaatc ggttctgcgt aataaaaccg attggatccg ttcgcaccta 3758341 atacctttac caaactcgga atatgaaaat ttgaaatatg atcctcactg ggataataga 3758401 ggtctccatt tatgttttca tgtaacacct cagccaaatc ctctctcgcg aactcgtccc 3758461 ttaaagcgcc tatcgacgtc attaaagcca gcgccagctc agcatgtgtt tgaaagccgc 3758521 aagaagacat aaccttcttc caggaaacag ccttgcctat tcctcttatt tcattatcgt 3758581 ttggataaat atgttcataa tcattttttc tttttgcatt ctcccatcct tcaggcattt 3758641 ggataaaagg agaaaagata agagcagcag atgagtattc aactggtact tgttgtaaga 3758701 ttggtgattc gtcatctaac catatataat ctagcatgcg cacctccttt acatattcta 3758761 acattccttt cgtttgaaag agatgatcag ccctatgaca ggctgatcat ctatcacatc 3758821 acatttttat ccccagattc aaccgcactc tcttcccgcc atttttgatg atcccatatt 3758881 ctgaaaaacg gatagtagat agcacaggtg atcagcagat ttaccagctg cataactgcg 3758941 cccgacacct ttccgcctgt cgccaggtaa cctgatatga gcggcggcat cgtccatggc 3759001 accgcgattc cggccggtct tgccaccagc ccggtgctca tgccgatata agtcgcggta 3759061 atcgtgagga gcggtgcgat gataaatggg acaataagga ggggattcat gacaatcggc 3759121 atgccgaaaa tgatcggctc gttgatatta aatagcgcag ggccgattcc taatcgtcca 3759181 agctgcttca tttgtttgct gcgggagcgc acaagcatcg tcaggacaag cgccagcgtc 3759241 gccccgcttc cgccgacatt gatccaaatt tgaaaaaact gagtcgtaaa aatactcggc 3759301 agcgcctcgc ctgcttggaa ggcgagacgg ttggcatcca tcgcgccgta ccaaatcggc 3759361 gccatgattc cgccaatgat ggaagccccg tgaatcccgc acgaccaaag cagcatctgc 3759421 acaaattcag cgatcaggct tccgccgaga ctgccgccaa ggatggaaag cggtgtgcca 3759481 agcaggtctc ctacgacatt gtgcagactc tgaaaaggtg tcatttcaat cagaagacgc 3759541 gccagccata cgagaagcac aatgataaag ccgggaatca gcgcgacaaa tgatttgctt 3759601 accgcaggcg gcacaccgtc tggcattttg aagacgatat ttttttgaat aatgtaccga 3759661 tagatttcgg ttgaaaacaa ggcgatcagc atggcgacaa ataagccctt gctgccgagc 3759721 agcgtgatcg ggattccgcc ccctaccatg atggactccg ttgagccatg cggtgtaaac 3759781 ggcacctcaa acggtgttgc cagcagaaat gcggcaattg aaatcgctcc ggcagaaagg 3759841 gcatcgacac catagctttc tgccagccga taggcgatcc caaaagcggc aatcatcgcc 3759901 ataatatcaa acgaagcgtt aacaggatat ccgagcttat cggcccactc gttcccaaac 3759961 acactcgcca tgaaatcagc ataccccgga atcggcaagc tcgttaaaat caagaagaca 3760021 gacccgataa taatcagcgg catggtcagg ataattccgt cacgcaaagc gctgagatgc 3760081 cgctgcccgg caattttccc ggcgacaggc attatttttt cctccatcac ccgagtgaat 3760141 gtgctcatct taaaaacccc cttttctcat tgctttgtga acaacctccg caatgttttc 3760201 tttatcttat tttgaaaacg cttacaaatt catttggaaa atttcctctt catgcggaaa 3760261 aaatctgcat tttgctaaac aaccctgccc atgaaaaatt ttttccttct tactattaat 3760321 ctctcttttt ttctccgata tatatatcaa acatcataga aaaaggagat gaatcatgaa 3760381 aaacatgtct tgcaaacttg ttgtatcagt cactctgttt ttcagttttc tcaccatagg 3760441 ccctctcgct catgcgcaaa acagcagcga gaaagaggtt attgtggttt ataaaaacaa 3760501 ggccggaaag gaaaccatcc tggacagtga tgctgatgtt gaacagcagt ataagcatct 3760561 tcccgcggta gcggtcacag cagaccagga gacagtaaaa gaattaaagc aggatcctga 3760621 tattttgtat gtagaaaaca acgtatcatt taccgcagca gacagcacgg atttcaaagt 3760681 gctgtcagac ggcactgaca cctctgacaa ctttgagcaa tggaaccttg agcccattca 3760741 ggtgaaacag gcttggaagg caggactgac aggaaaaaat atcaaaattg ccgtcattga 3760801 cagcgggatc tccccccacg atgacctgtc gattgccggc gggtattcag ctgtcagtta 3760861 tacctcttct tacaaagatg ataacggcca cggaacacat gtcgcaggga ttatcggagc 3760921 caagcataac ggctacggaa ttgacggcat cgcaccggaa gcacaaatat acgcggttaa 3760981 agcgcttgat cagaacggct cgggggatct tcaaagtctt ctccaaggaa ttgactggtc 3761041 gatcgcaaac aggatggaca tcgtcaatat gagccttggc acgacgtcag acagcaaaat 3761101 ccttcatgac gccgtgaaca aagcatatga acaaggtgtt ctgcttgttg ccgcaagcgg 3761161 taacgacgga aacggcaagc cagtgaatta tccggcggca tacagcagtg tcgttgcggt 3761221 ttcagcaaca aacgaaaaga atcagcttgc ctccttttca acaactggag atgaagttga 3761281 attttcagca ccggggacaa acatcacaag cacttactta aaccagtatt atgcaacggg 3761341 aagcggaaca tcccaagcga caccgcacgc cgctgccatg tttgccttgt taaaacagcg 3761401 tgatcctgcc gagacaaacg tccagcttcg cgaggaaatg cggaaaaaca tcgttgatct 3761461 tggtaccgca ggccgcgatc agcaatttgg ctacggctta atccagtata aagcacaggc 3761521 aacagattca gcgtacgcgg cagcagagca agcggtgaaa aaagcggaac aaacaaaagc 3761581 acaaatcgat atcaacaaag cgcgagaact catcagccag ctgccgaact ccgacgccaa 3761641 aactgccctg cacaaaagac tggataaagt acagtcatac agaaatgtaa aagatgcgaa 3761701 agacaaagtc gcaaaggcag aaaaatataa aacacagcaa accgttgaca cagcacaaac 3761761 tgccatcaac aagctgccaa acggaacaga caaaaagaac cttcaaaaac gcttagacca 3761821 agtaaaacga tacatcgcgt caaagcaagc gaaagacaaa gttgcgaaag cggaaaaaag 3761881 caaaaagaaa acagatgtgg acagcgcaca atcagcaatt ggcaagctgc ctgcaagttc 3761941 agaaaaaacg tccctgcaga aacgccttaa caaagtgaag agcaccaatt tgaagacggc 3762001 acagcaatcc gtatctgcgg ctgaaaagaa atcaactgat gcaaatgcgg caaaagcaca 3762061 atcagccgtc aatcagcttc aagcaggcaa ggacaaaacg gcattgcaaa aacggttaga 3762121 caaagtgaag aaaaaggtgg cggcggctga agcaaaaaaa gtggaaactg caaaggcaaa 3762181 agtgaagaaa gcggaaaaag acaaaacaaa gaaatcaaag acatccgctc agtctgcagt 3762241 gaatcaatta aaagcatcca atgaaaaaac aaagctgcaa aaacggctga acgccgtcaa 3762301 accgaaaaag taaccaaaaa cctttaagat ttgcattcca agtcttaaag gtttttttca 3762361 ttctaagaac accacacaca acctttttcc catccattgt acaggctttt catactattg 3762421 ctatacagcc atgaacagca taaaatgaac gttattacag ttatcaccac atatggcggg 3762481 attgtgactg ggcaggcagg caagacccaa tgatgcaaag ggagtattaa tgcctaaaaa 3762541 acagggcatt ttaactcttc ttttcgtgtt gggctcataa cggcgccttg gacaaccccc 3762601 tattctcatg ctccgtcgtc gacgcgggca tttttgtcat tttcagccgg tatttctcac 3762661 ttttttcatt ttgattgtca acttttcatt tgatacgatg aacaagccga cttttcttca 3762721 gcaaaggagg ttttaattgc ttgcataaag agattgcaaa agaattactg ctgctcgcag 3762781 gaggaaaaaa caatattatc agcatcagcc attgtacgac ccgtcttcgt tttgatgtaa 3762841 aggacgagac gaaaattgat atacatgcca ttgagaacct gcaaggtgtg cagggcacct 3762901 ttttccgcta tgggcttttc cagattatct tcggagcagg cgtcgtcaac aaaatatata 3762961 aagaagtcgt tcatgtatgg gagaccgcgc cttctgaaga gcctgtccac cagaaaaaag 3763021 ccagccggaa gctgaaccct gccgcagctt ttgcgaaaac actgtccgat atttttgtgc 3763081 cgattattcc ggcaataaca gcaagcggcc tgctcatggg gctgatcggc atgattaagg 3763141 tgtttcattg gttcgctgcc ggcagcccat ggattaaaat gctcgacctc gtgtccagca 3763201 cagcctttat tttactgccg attttagtcg gcttcagtgc tgcacggcaa tttggcagca 3763261 acccatacct aggggcagtg attgcagggc ttttgacgca tcctgatctg ctggacccgt 3763321 ctatgctcgg cagcaaaacc ccgtcttctt tagacatatg ggggcttcat atcccaatga 3763381 tgggctatca gggttccatg ataccgattc ttctttccgt ttttgtcatg agcaaaattg 3763441 agaagctatt aaaatcgatt gtgccgaagt cgcttgatgt cgtgatcatt ccctttatta 3763501 cggtcatggt gacagggtgc ctcgcgctga ttgtgatgaa tcccgccgcg tccatcatcg 3763561 gccagatcat gacacaatcg atcgtctata tttatgatca cgccggcatt gctgccggag 3763621 ctcttttcgg cggcatctac tccaccatcg tcctatctgg attgcatcat agcttttatg 3763681 caattgaggc aacgctgctt gctaatccgc atgtcggtgt caacttttta gtgccgatat 3763741 ggtcgatggc gaatgtggcc caaggcggag cggggcttgc ggtattcctc aaaacgaaac 3763801 aatcaagcct gaagaaaatt gcgctccccg cttctctgac cgcgttttta ggcattgttg 3763861 agccgattgt attcggggta aatctcaaat tgatccgtcc ctttatcgga gcagccatcg 3763921 gcggtgctat tggcggagca tacgtggttg cggtacaagt tgtggcaaat tcctacggac 3763981 tgacaggcat tccgatgatt tcaatcgtgc tgccgtttgg cgccgctaat tttgttcatt 3764041 atatgatcgg tttcttgatc gcagccgtct ctgcttttat agctacattg tttctcgggt 3764101 ttaaagaaga gacagaataa ctggatttat tcgatttcat tcataaaacg ggggatgaaa 3764161 ggacaaaaaa gctatgaaaa ttaaaagaat cttaaatcat aatgctatcg tcgtaaagga 3764221 tcaaaatgaa gagaagattc tcttgggtgc aggaattgcg tttaacaaaa agaagaatga 3764281 tattgtcgat ccgtcaaaaa tagaaaaaac ctttatcaga aaagatacac ctgactataa 3764341 gcagttcgaa gagattttag aaacattgcc tgaagaccac attcagattt ctgagcaaat 3764401 tatctctcat gccgaaaaag agctgaacat caaaatcaac gagcgcattc atgtcgcttt 3764461 ttcagaccat ctttcttttg caattgaacg cctgagcaat gggatggtta tcaaaaatcc 3764521 gctgctgaat gaaatcaaag tcctttatcc aaaggagttc cagatcggct tatgggccag 3764581 agcactgatt aaagataaac tggggattca cattcctgat gatgaaatcg gcaatatcgc 3764641 catgcatatc cacacagcaa gaaacaatgc cggcgatatg acacaaacgc ttgatattac 3764701 aacaatgatc cgtgatatta tcgagattat cgaaattcaa ctgtctatta atatcgttga 3764761 agataccatc tcttatgaaa ggctcgtgac ccatctccgc tttgccattc agcatatcaa 3764821 agcaggcgaa tccatttacg agctggacgc agaaatgatt gacatcatta aagagaagtt 3764881 taaggatgcc ttcctgtgtg ccctaagcat cggcaccttt gtgaagaagg aatacggctt 3764941 tgagtttcct gaaaaagaat tgtgctacat cgccatgcat attcagcggt tctaccaacg 3765001 gtcagtcgca cgctgagaca aacaaaaaac gcttttgatc atctcaaaag cgttttttta 3765061 tctgatttat tggttgatcg ccggattccc aatcgtattc cacttcgtat aggacatgta 3765121 atggaaatac tcatcgcgat acggatgttt tgtattggag ttccaaggct tttctccgcc 3765181 gcagaagtgc acgattgccg ggttttctct tgtttcatta tattgcttcc gccctaacag 3765241 agtcgatggg gttttcagct ttaacatgat ataggtttga gcgttccagc gcggatgaag 3765301 ttcataccac tgatcataca agatcgcatt cagtgcatct tggtcatgca gcacaagaaa 3765361 gtcttcgtct gggtgttcat tgataaagtt gatgactttt tctgtgatgt tttgctttct 3765421 ccaagactca aaatcaataa tcatgatacc tgagttaaaa tacttccctg tatcagtgac 3765481 gttcatttct ttcaggcgtt catgctgccc cgcatcctca acagcggcta cggtgtatgg 3765541 cgcaatgtct aagtcccata gcttagaaat atcctctagg acaagcgcat cacaatcgat 3765601 gtaaatcatt cgtttgatgc tttcatcctt aattaagtcg ggaatcgaaa tgcggtaata 3765661 cgcggctttt gtaatatggc tgctctcaac cgcatgttca tacatgttgg tatccacttc 3765721 taaaaactca atcggcactc cgaatttcaa agtggtttct tccagtcttt ttttgttatc 3765781 aggcttaatt ccgccatcaa tgacgtataa ttttacctct ctctcctgat ccatgttagt 3765841 caataaagaa acgaacatcc cacctaaatg acgagcataa ttatcatctg cgcatgatac 3765901 gatatgcatg atttcatctt tcctcaatgg tattcatctc cctttttgtt gtacaagtta 3765961 catacccttt ttcaaaaaaa taaacacgtt ctccgacatt tttttaaaca gaatgtgtga 3766021 tacaacaaaa aaggtgtcat tttttgaaga tgcgataaag ccaataaaga atgaaaaagc 3766081 ttgcgattgt gatggcttca gccgagacga tataccacgg ccatggcccg agaacatcta 3766141 agagagagga accgcccggt tttttcgtca aatacatata attcgcgcca agccagcgat 3766201 caatcagaaa aatacagacg ccgtacacat taacaagcag gactgtcacc cataacgagc 3766261 gctggcccat tctgtaggtg ccaatcacag ccatcagcag acaggataaa aacacagacc 3766321 cgtgagaaat aaaaaagagg atatatcgga tatgcggaaa tgaaaacata ccgaggtcag 3766381 gagtggcaag agcctgaatc gaactgccga tgccgacaaa aaacaaaaac acaaacagct 3766441 ttctgctttt tgtcactaac ataatagctg acaaatacac cgacaggtca ctaagctgga 3766501 gaggcaatga agtgcgcacc gaccacctgt ccgtggcgac catccatatt tgatagccga 3766561 tttgcgaacc aagcaaaaga aacacaaaca gagaacgcaa aaaccggctg gccctcggct 3766621 gcttgacctc atcttggaac aaaaacaaca gaatggccaa aagggagata atcgctaacg 3766681 tcactacatg ctctgtcgaa aacagatgaa acggatcatg cttatagtcg gattgaacat 3766741 atttttgcaa aactgcaccc ccgttttcgg gtttttgttt attttggcgt tgtttgggct 3766801 ttttttattc aaccgatata tgggcttgaa gttcacacca gactctgtta aaattcgttt 3766861 catagctaat gattctgata atttaaggca ggcctaaaaa atggaacgtt cacatcaaca 3766921 tcagcagctt cggaaggaag aacacgatac actttctaag ctcaaacaaa tgcccgtcga 3766981 gtcactcaac ctggaagcca tttcgatcgc tacgaatctg tatcggtctg cacaaaggct 3767041 ccgtgtcaaa atggagactg aggttctttc tacctataac ctttcttgga ccgctttctc 3767101 cattctttat gatctatggg tatggggagc gctcgaaacg agaaaaatcg ctgagctgtc 3767161 agggatatct acagctacag caagcaacgt gatcaaaacg ctcgaaaaaa agagtttttg 3767221 ccgtaaaagc atcgacacaa gagatcggcg actcgtgttt gtctcaatca ccgattccgg 3767281 caaacaagcg atcgaagaac tctacccgga gtttcacaaa ggggaaacag agctcattgc 3767341 gggaatgacg aaggacgaac agaaaatatt gacagggctg cttagaaagg tagctgacaa 3767401 tcttcataca acataagctt tgacgggaat ccagtagcgg tttgtctccc tgtttcagag 3767461 agccggcggt aggtgcgagc cggcgcacag gcaaacgtga attacctccc caagctttct 3767521 ttgtgaacct tagtagcaaa gaacgggaaa ccgttattcg aatgagcgga agacaatgtc 3767581 ttcaaccagg gtggtaccgc gtgcattgag ccacgtccct tattgggatg ggctcttttt 3767641 tgtgtttgta aaaaaggagg aaaaatgatg agaacatttg agcagctcac agcgtcacaa 3767701 caaaaagagg tagaaagaca gcttcagcta tacatgacag gcgcccacga agtcataccg 3767761 ccggaggaat taaaggcaaa gctcgtgaaa tcaatttcca cgggcacgcc gcttaaaatt 3767821 aagctcggat tagatccgtc tgcaccggat gtacatttgg gccatacggt tgtgttaaat 3767881 aagcttcgcc aatttcaaga aaacggccac attgtccagc tgttaattgg ggatttcaca 3767941 ggaaaaattg gtgatccgac cggaaaatcg gcagccagaa agcaactgac tgatgaagaa 3768001 gttcagcaca atgccaaaac ctactttgag caattcggaa aagtgcttga tccagaaaaa 3768061 gtcgagcttc actataactc aaaatggctg aaaacattga atctagaaga tgtcattgaa 3768121 ttagcaggga aaataacggt agcccgcctg atggagcgcg acgactttga agaacgcatc 3768181 gccatgcaaa aaccaatctc actgcatgaa ttcttttacc cattgatgca gggctatgat 3768241 tctgtcgttc tcgaaagtga tattgaatta ggcggaacgg atcagcattt caatgtcctc 3768301 atgggacggc atttccaaga acgatacaac aaagaaaaac aagtcgtcat ccttatgccg 3768361 ctcttggaag gcttggatgg cgtcgagaaa atgtcgaagt cgaaacacaa ctacattggc 3768421 attaacgaac atccaaacga catgtacgga aaaacgatgt cactgcccga cagcctgatg 3768481 aaaaagtaca tccacttggc gacagactta gagcttgaag agaaaaaaca gctcgtaaaa 3768541 gacttagaaa ccggcgccgt tcatccgcgt gatgccaaaa tgcttttagc cagaacaatc 3768601 gtccgaatgt atcacggaga gaaagcagca gaagctgccg aacactcgtt taaaacagtc 3768661 tttcaggaaa acagcctgcc ggaagatata ccggccgtaa actggaaagg cgaaaaaacg 3768721 atagcgatga ttgatctgct cgtcaagcta aagctcctct cttcgaagag cgaggcgcgc 3768781 cgcatgattc aaaacggagg tgtacgcatc gacggagaga aagtaacaga tgttcacgcc 3768841 aaagcagaga taagagagaa tatgatcatc caagtcggca aacgcaagtt tttaaagctc 3768901 caataatctg atattccgaa acgcttatga cccttcattc ataagcgttt ttttgcaggt 3768961 ataaagcact gtcttttcaa aaacgctctc catcttgcag gaaactcctt tagcatcccg 3769021 aaatattccc caaccataca tttaggggag gtttattttt gatgaaaaag cttttgactg 3769081 tcatgacgat ggctgtttta actgccggca cactgctctt gccggcacag agtgtcaccc 3769141 ctgccgcgca cgctgtacaa atatcaaata gcgagcgcga gcttccattc aaagcaaaac 3769201 atgcgtactc taccatttct cagctaagtg aagcaatcgg ccccagaata gccggaactg 3769261 cagctgaaaa aaagagtgcc ctattgatcg cctcatcaat gagaaaatta aagcttgatg 3769321 tgaaggttca acgattcaac attcctgacc ggcttgaggg tacactgtct tcagcaggac 3769381 gcgatattct tctccaagcg gcgtcgggct cagctccgac tgaggaacaa gggctgacgg 3769441 ccccgcttta caatgcggga ttgggctatc aaaaggactt taccgctgac gccaagggca 3769501 aaatcgcctt gatttccaga ggagacctga cttattacga gaaagccaaa aatgccgaag 3769561 ccgccggagc gaaagctgtc atcatttata acaacaaaga aagcctcgtg cctatgacgc 3769621 caaacctgtc gggaaataaa gtcggcattc cggtcgtcgg cattaagaaa gaagacggcg 3769681 aagcacttac ccagcaaaaa gaagccacct taaaactaaa agcattcaca aaccaaacct 3769741 cccagaatat catcggaatc aaaaaaccaa agaacatcaa acatccagac attgtgtacg 3769801 tgaccgccca ttacgacagt gttccttttt cgcccggagc aaatgacaac ggctcaggta 3769861 cctctgttat gctggagatg gcgcgtgtct taaaaagcgt tccatctgat aaagaaatcc 3769921 gctttatcgc tttcggcgcc gaagagctcg gcctgctcgg ctcctctcac tatgtagatc 3769981 atctatcgga aaaagagctg aaacgaagcg aagtgaactt caacttagat atggtaggca 3770041 caagctggga aaaagcgtct gagctgtatg tcaacacatt ggatggccaa tctaactatg 3770101 tttgggaatc cagccgtacg gctgctgaaa aaattgggtt tgacagcctg tctctgacac 3770161 agggaggatc atctgatcat gtgccattcc acgaagccgg cattgattcc gctaacttta 3770221 tttggggaga cccggaaaca gaagaagttg agccgtggta tcatacccct gaagactcga 3770281 tcgaacatat cagcaaagaa cgcctccagc aagcaggcga tcttgtgaca gccgctgtct 3770341 atgaggctgt gaaaaaagag aagaaaccga aaaccattaa gaaacaaatg aaggcgaaag 3770401 catctgacat ttttgaagat atcaaataaa aaaagacggc acttgggtgc cgtctttttt 3770461 aatccacttc tttcttaatc cccagcattt tctcatctag gtaatgggca atctccgcgg 3770521 cttctttcag ctcatctgtt aattgcttag gaacgtcatt gttcaattta taataaattt 3770581 tatgttcaag gctcgcccag aaatccatcg cgattgtccg gatttgaatt tctgctttga 3770641 cgtattccac acggttcgtt aaattcacag gcatctcaat gattaaatgc aggcttcgat 3770701 agccattcgg tttgggtgtc tggatataat cctttacctt tacgattctc aaatcttcat 3770761 gctgcttcaa cacattcacg acattataaa tgtcagaaat aaaggaacag atgatgcgca 3770821 cgccggcaat gtcgtgaata tgctccttca tttccttcgt cgtaatctca cagccctttc 3770881 tcattaactt attcacgatg ctttcaaagc tttttacacg ggattttgta tgttcaatcg 3770941 ggttgtgtcc gtgaatgagg ttatattcct ggctgataat tgagaacttt gtatcgagcg 3771001 catctagcgc aaatttataa actaataact catttttcca atcttccatt actgttttta 3771061 aatcgtccat atgtgttaca gataaatcca tgttcgtcat ctcctttaac ggaactttat 3771121 ccgctgtcca tgtactagac gtccctgtct gctgcaaggt tctatgaatt tttttacaaa 3771181 atgcggtcga ttgtaacaaa aaaagaccgc atgaaacgag cggtcttttt tattatcgga 3771241 aatagctgat caataatccg atcgagagca ggaatccgaa aaatgtattt gtttgggctg 3771301 ttgatttcat tgcgacaatc atattcatcg gcatttcgtt ctggacgaag cccttcactg 3771361 cctgaaccgg cttaggcacg ctcaaaaaga cgacaaacag ccatgggctt gcggcaccgg 3771421 taataaccaa gccgacaacc cagatataag cgacggcaaa cgacgcagct aacagagtaa 3771481 cagctccctt atgccccatc aaaatcgcca atgttttgcg tccgcctttt ttgtcctctt 3771541 caatatcacg aatgttgttc gacaggttaa tcgcgccgac aagaatcgca atcgggatgg 3771601 aaatcaaaat gctctgcata ttgatcttat ctgtctgaat gaaaaacgaa atcagcacaa 3771661 acaccgaacc catgcaaatg cctgagaata attcaccgaa cggcgtgtac gcaatcggca 3771721 gcggcccgcc tgtatacagg tagccgatcg ccatgccgac aaggccgatc agcgcaagcc 3771781 accagctgct gctggcacaa atatagacac cgagcaaaat ggcaatcccg tatgaggcaa 3771841 gagctaattg caaaatcgtt ttaggcttca ttccgtggcg tacaatggcc cctccgattc 3771901 cgactgattc tgctgtatct aatccgcgtt taaaatcata gtattcatta aataagttcg 3771961 tcgcgatctg gatccatagg caagaaaaca gcatagccaa aaacagcagc agatcaacct 3772021 tcacataaaa catcgccaaa acggttccga gcagcacagg cacaaacgat gcggttaacg 3772081 tatgaggacg ggttaactgc caaaggatct gccccatgct ttctttttgc ggcgctgtct 3772141 gaccctcacc cttatttgtt tggttcatct tcctcttcct ttctattaaa aggcttactt 3772201 tttttcagcc ggcagcttaa taaaaaactc cttttgcttc cttatctatc ataatgactt 3772261 ctcccttatt tcacaagata ccgcaagaag gcgttttctt tcttattata cgcttctcgc 3772321 cctgatttca ttaggtttct gctttcactt gaacgaacag gtacagaaaa atttttttaa 3772381 gtacattaca ctttttaaaa gttaaaaaga tcttttgact ccaggtatct tttcctttat 3772441 tatgaatcag ctcgaaacat tccattcttg cccttgcagg tataaagatt cattttcaaa 3772501 aacatacgcc gatatattaa tttgagggag attagggaaa aaatgaaact ttttgagcat 3772561 ctgatcgtca aataatcatg tgattgtcga aaaaacggga agggaatttt tgatatgctg 3772621 caattaatga aacagctgta tgaaaaaccc gctgtcaagt ggacatgtca tacaggcttt 3772681 tatttgatga tactgcttgt tttgtttttt atgtatggtt ttcacaccgc gaataccggt 3772741 tcatatattt ataacgattt ctaattggag agagaataac tatgaaactt ttacatgcta 3772801 ttcaaacaca tgcggaaact tatccgcaaa ccgatgcctt ccgctctcaa ggccagtcgc 3772861 tcacgtatca ggaattatgg gagcagtctg accgcgcggc tgccgcgatc caaaaacgca 3772921 tttctgggga aaagaaatct cctatccttg tgtacggcca catggagccg cacatgatcg 3772981 tttccttctt gggaagtgtc aaagcgggac atccttatat tccggttgac ctgtctattc 3773041 cgtccgaacg gattgcgaaa attatcgaaa gctctggagc agaattgctg atccatgcag 3773101 caggactctc aattgatgca gtcggccagc agattcagac agtttctgcg gaagaactgc 3773161 tggaaaacga aggcggctct gtcagccaag atcaatgggt caaagaacac gaaacgtttt 3773221 atatcattta cacttccggg agcacaggaa atccgaaagg cgtgcagatt tccgctgcga 3773281 accttcaaag cttcacagac tggatttgtg cagactttcc agtcagcgga ggaaaaatat 3773341 ttttaaacca agcgccgttc tcatttgatt tgtctgtcat ggacctatat ccgtgccttc 3773401 aatcaggcgg gactttacat tgcgtgacaa aggatgctgt gaataagccg aaagtcttat 3773461 ttgaagagct gaagaagtcc gggctgaatg tgtggacatc aacaccttcc tttgtgcaaa 3773521 tgtgcctgat ggatccgggt ttttcacagg atctgctgcc tcatgcggac acatttatgt 3773581 tttgcggaga ggttcttccg gtttctgtgg ccaaagcgct gcttgagcgt tttccgaaag 3773641 cgaagatttt taatacgtac ggcccgactg aagcgacagt ggctgtcaca tcggttgaaa 3773701 ttacgaatga cgtcatcagc cgcagcgaat cgcttccagt gggcttcgcc aaaccagata 3773761 tgaacatttt cattatggat gaagagggac agccgcttcc tgagggagaa aaaggagaaa 3773821 tcgtcattgc agggccgagt gtaagccgag gctaccttgg tgagccagag ctgacggaaa 3773881 aagcgttttt ctctcatgaa ggccagtggg cataccgaac tggcgatgcc ggctttattc 3773941 aagacggtca gattttctgc caaggacgtt tggattttca gattaaactt cacggctatc 3774001 gaatggagct ggaggaaatc gagttccatg tcagacagtc acagtacgtt cgttctgctg 3774061 tcgtgattcc ttatcagcca aacggaacag ttgagtatct gatcgctgct attgtgcctg 3774121 aggagcatga gttcgagaag gaattccagc tgacaagcgc tattaaaaaa gagcttgccg 3774181 cttctcttcc ggcatatatg atcccgagaa aatttatcta tcaggatcac attcaaatga 3774241 cggctaacgg caaaattgac cgaaaacgca ttggcgaaga ggttcttgta tgacgcctta 3774301 cagctcgttt ttattcttta tactgcttgg cattcttctt ctgccgacga tcattctcgg 3774361 cttaaacgga aaaagatttc aagcatacaa catgttcata tctatcatta tattggcttt 3774421 aattttttcg cacgacttac acggggtcat cgcgctgtgc ctgtttacaa tatggcaggt 3774481 gctcctgatc agcggctatc tggcataccg gcagaaagcg aacagcggct ttgtcttttg 3774541 cggagctgtt atcgcgtcta ttctgccttt atttctgtca aaaatatggc cgtttctttc 3774601 acacccgcag ccgcatcatc cgccgcataa cctgatcagc tttttaggga tttcatattt 3774661 aacctttaaa ggcgttcagc tgattatgga agcaagagac ggactgctga aagaacagct 3774721 gccattgcac cgtctgctgt atttcatcct gtttttcccg acgatttcct ccggcccgat 3774781 cgacagatac cgccggttcg tcaaggatga acagaaggct tggacgaaag aagaatacgc 3774841 cgacctgctg tatacgggaa tccataaaat cttcatcggt ttcctgtata aatttattat 3774901 cggctacgcg atcaatacgt acttcatcat gaatcttccc gcaatcacgc acaataagat 3774961 tcttgggaac ctgctgtaca tgtacggcta cagcatgtat ttattctttg atttcgccgg 3775021 ctacacgatg tttgccgtcg gggtcagcta cattatgggc attaaatcac cagaaaactt 3775081 taataaaccg tttatcagta aaaatattaa agatttctgg aatcgctggc atatgtctct 3775141 gtcattttgg ttcagagatt atgtgtttat gagattcgta ttttggatga ctaagaaaaa 3775201 gtggatcaaa aaccgtatgg ccgtctcaaa catcgggtat ttcctgctgt ttatgctgat 3775261 gggggtttgg cacgggctcg cgccgcaata tatcatttac ggcctctatc acgccgttct 3775321 gatgacgtgt tacaactttt tcgagaagtg gaataagaaa tataaatggc tgccgtccaa 3775381 ccgctggaca accattctcg ctattgtgat cacattccat ttcgtttgct tcgggtttta 3775441 tattttctca ggaaaaccat ttcatcacca ccattaaagg agattagaaa gctatggatt 3775501 ttaaacaaga ggtattagac gttttagcag aggtttgcca ggatgacatc gtaaaggaaa 3775561 atcctgatat tgaaattttt gaagaaggtt tgcttgattc ttttggaaca gtagaattgc 3775621 tgcttgcgat tgaaaaccgt tttgatattt tagtgccgat cactgaattt gaccgggacg 3775681 tttggaatac acctaacaac attgtaaatc agctgtctga gttgaaataa tgaaaaagcg 3775741 ttttttcggt ccaattattt tggcgtttat tctattcgca ggcgccatcg caattccatc 3775801 ttcatggctg acaggcttca tcaccgataa gcgtgtgaaa gagtcagcaa cagccttgaa 3775861 tccgagtatg tttcaagggc tatatttaca agatcagatg ctcaaagatc cgacatatct 3775921 tccgatttac gggtcttctg agctttctcg gctggacgag ttccacccat ctaattattt 3775981 tcaggtaaac aatgagggat tcacgccata ccttgtcggc aaaggcggat cccagtcatt 3776041 gattcattct ttaaacttcg ctgcccacat ggatcagctg aagggcaaaa aaatcgtatt 3776101 catcgtgtct ccgcaatggt ttattaagcg cgggtctgat gaacagcatt tcgcgccgaa 3776161 ctattctgcg ctgcaagggc ttgatttggc atttaacgat cagatcgatc ctgaaattaa 3776221 aaagaaaatg atgaaacgca tgcttcgctt taaggctgtg caaaacgatg ccattctttc 3776281 tgagctgtac aaagcaatgg taaacggtca gacgtggaaa gtgaacgcgc tgaagccggc 3776341 ggcgaaagtg tattacagca tgctggaaaa gaaagatctg tattattcaa cgacagaatc 3776401 atccgggcca aagcgctata tctcgcagtc agtaaaggat aagtcatggt ctgaattgaa 3776461 taaactagcg gatcaatcgg gcaaacgcca ctccggttct aacgattttc acatcgacaa 3776521 ccctgtctat aaaaagctga agccgaaagt gcctaagctg aaagggaaaa acaaaggaag 3776581 atcgtatgcg gtgtcaccgg aatatggcga ctttgaaatg atgctcgata tcctgaagga 3776641 tgcgggcgca gagcctatgt ttgtcaccat tcctgttaac gggaaatggt acgattacac 3776701 gggcttcccg aaaaaaggac gcactgacta ttacaaaaag gtaaataaac aaatcagagc 3776761 gaagggcttc caggttgctg atttctcagg gcatgaatat gacccgtatt tcatgaaaga 3776821 caccattcac atcggctgga aaggctgggt gtatgtcgat aaagcaattg acgaatttta 3776881 taaaaccgga aaagtcactt catcctgagc atctcatagg acgcggctgc atatttcctg 3776941 ctaagatttg taatagtaaa ggaatcacag ccaacttaat taagaggtgt tacatccaat 3777001 gaagatgaca aataatacgg ttttaatcac agggggttct gctggcatcg ggcttgaact 3777061 ggccaagcgc ctgctggaac ttggcaatga agttatcatt tgcggacgca gcgaagcacg 3777121 tcttgcagaa gcgaagcagc agctcccaaa catccataca aagcaatgtg atgttgcaga 3777181 ccgttcgcag cgggaagcat tgtatgaatg ggctttaaag gaatatccga acttgaatgt 3777241 tctcgtcaac aacgccggca ttcaaaagga aattgacttt aaaaaaggga cagaggagct 3777301 ttttgtggac ggtgatgaaa ttgaacttaa tttccaagcg cctgtccatt tatccgccct 3777361 tttcacacct catttgatga agcagcccga ggcggcaatc gttcaggtca catccgggct 3777421 tgcgtttaac ccgttagctg tttatccggt gtactgcgca acaaaagcgg cacttcactc 3777481 gttctcgctt acgctcagac accagctccg cgacacgagc gtggaagtga ttgaaatggc 3777541 accgcctatg gtggacacgg gcttaaacca aaaatcacgc gataaacaag gcctgacgta 3777601 ccggggcatt tcatctgaag aatatgttca atatttcttg gacggcttga aggaaggcaa 3777661 acaggagatt acaaatgaac gtgttgaagg tcttcgggat gccactcgcg ccgattatga 3777721 caggttattc gagcaaatga acacgcagga gaattaattt ctcctgcttt tttcatatga 3777781 atttcttaca aatttgagca aacctattgc gattatttgt tgaaggtata caatagaata 3777841 taattatttt caaataagtt tgataatata aacaatttaa cagcagggag attgaccatg 3777901 actaaacaaa caattcgcgt tgaattgaca tcaacaaaaa aaccgaaacc agacccaaat 3777961 cagctttcgt tcggaagagt gtttacagac cacatgtttg taatggacta tgccgcagat 3778021 aaaggttggt acgatccaag aatcattcct tatcaaccct tatcaatgga tccggctgca 3778081 atggtctatc actacggcca aaccgtgttt gaagggttaa aggcttacgt gtcagaggat 3778141 gaccatgttc tgcttttcag accggaaaaa aatatggaac gcctgaatca atcaaacgac 3778201 cgcctctgca tcccgcaaat tgatgaagaa caggttcttg aaggcttaaa gcagcttgtc 3778261 gcaattgata aagactggat tccaaatgcg gagggcacgt ccctttacat ccgtccgttc 3778321 atcatcgcaa ccgagccttt ccttggtgtt gcggcatctc atacgtataa gctcttgatc 3778381 attctttctc cggtcggctc ttattacaaa gaaggcatta agccggtcaa aatcgctgtt 3778441 gaaagtgaat ttgtccgtgc ggtaaaaggc ggaacaggaa atgccaaaac cgcaggaaac 3778501 tatgcttcaa gcttaaaagc gcagcaggta gccgaagaga aaggattttc tcaagtactc 3778561 tggctggacg gcattgagaa gaaatacatc gaagaagtcg gaagcatgaa catcttcttc 3778621 aaaatcaacg gtgaaatcgt aacaccgatg ctgaacggga gcatcctgga aggcattacg 3778681 cgcaattcag tcatcgcctt gcttaagcat tggggccttc aagtttcaga acgaaaaatt 3778741 gcgatcgatg aggtcatcca agcccataaa gacggcatcc tggaagaagc cttcggaaca 3778801 ggtacagcag ctgttatttc cccagtcggc gagctgatct ggcaggatga aacactttcg 3778861 atcaacaacg gtgaaacagg agaaatcgca aaaaaactat atgacacgat tacaggcatt 3778921 caaaaaggcg ctgtcgcaga cgaattcgga tggacgaccg aagtcgcagc gctgactgaa 3778981 agcaagtaag aaaaaagccg gcccattaca ggccggcttt ttttacgctt caattttgtt 3779041 gaaaaactgc ggcagatacg ctttgtgcgc ctctagcatt tcgtctaaaa tctgtttggc 3779101 cacagtatcg gacgggacaa gcgggttaat cgtcatggca aggagcgcag tttgatagtc 3779161 acctgtaact gccgcttctg ccgcgacacg ttcaaaggat ttgatttgct ggacaaggcc 3779221 gcggacagac accggcaagt cgccgacagc aattggctta gggccggttt tcgtcatcac 3779281 acagttcact tcaactgcgg aatcgtctgg aatactcgct attgcaccat tattgatcgt 3779341 gttcaccggc tgaatgtcat gtttatcatt ataaatggag ctgattaagt tacatgctgc 3779401 atcactgtag taagctccgc cccgtttttc cagctgcggc ggtttgatcg caaggtttgg 3779461 atctttataa agctcgaaca gctctttttc gaccttctgt acgacttcag cgcgggtgcc 3779521 ctccgtttgt gatgcttcca gttcgtgctc cagcatctct tttgttttaa aatagtaacg 3779581 gtgatagccg caagggatga cattgagcgc ttttaagaaa tccggttccc attcggcgcc 3779641 tgagatattt ttcatcgtca tcgcgttttt cgggtcgccc atcgcctcga tgacttgctc 3779701 cttcacactt acgccgtcca agaaaacatc cagcccgaat accatatggt tcagtccggc 3779761 aaattggact tctacgcggt ccacatctac atcaagcgct ttggctacgc ccattttgat 3779821 gccgattgga acattgcaaa gaccgacgac tttcttcagg ttggagtagc gaagcaaggc 3779881 ttctgttacc atgccggcag ggtttgtgaa gttaacaagc caagcgttcg ggcaaagctc 3779941 ttctatgtcc tttgcgatct caaggatgac cggaattgtg cgcaatcctt taaacagacc 3780001 tcccgggccg tttgtttcct ggcctatcac tccgtatttt agcggaatgc gctcatcctt 3780061 tgctcttgcc tgcaaaagtc cgacgcggaa ttgggtcgtg acaaagtctg cgtctttcag 3780121 cgcctttctc cggtcgagcg taagatgaat gtcaatcggg acgccagctt tttcaaccat 3780181 ccgtttggcg agtgtgccga caatattcag cttttcttcg ccctcgggga tatcgacaag 3780241 ccataattca cggacaggca gctcatcata ccgtttaatg aacccctcca ctagctcggg 3780301 cgtatagctt gaacctccgc caatcgttac aatcttcaat ccttttgtca tatgcttgct 3780361 cccctttgct cggtgatttt ttcatataac tcaatgatct ctgcagccat atccttcact 3780421 gtcattgcat tcattaaatg atcctgtgca tgaaccatca gaagcgtcat ttccgtcttt 3780481 tctccgcccg cttcattttg gatcagctct gtctgataat gatgggcttt tgacaattct 3780541 tcagcagcgt cttgaagctt tttccgcgct tcttctgcgt caccgctttt cgcagcggca 3780601 atggcctcca ttgcggagct cctaccgttt cctccgtgaa ggatgatttg aaaaatgatt 3780661 tgttccattt cctcattcac gcgattcact tcctttctct acagagccgc ttctttgtca 3780721 tctgttgctg caggcgtttg gaccagctcc agatcgtttt cttctttcag cttctgctta 3780781 tcccacattc tgaagaatgg atagtagaca acaaaggaca cggcaatatt aatggcttgc 3780841 atgaccgcgc ctgagacttt tcctcctgtc gccaagtagc ctgaaaagat cggcggcatg 3780901 gtccacggca ctgcgatacc cgccggtttg gcgacaaggc cggtgctcat tccgatgtac 3780961 gtgagtgtca ctgtgacaag cggcgtgatg ataaacggaa gtaagagcat tgggttcatg 3781021 acgatcggca ttccgaatat aatcggttcg ttaatattga agatggccgg gccgaccgca 3781081 agcttcccga gctgcttcat ttgtttgctt cgggcgcgca ggaacatcgt gacaaccagt 3781141 gccaatgtgg cgccgcttcc gccaatattg acccagatat cgaaaaattg ctgggtgaaa 3781201 atcttaggaa gctcctcacc ggcttggaat gcgatccggt tggcatccat tgcgccgtac 3781261 caaatcggtg ccatgacgcc gccaacaatg tttgcaccgt gaaggccgca ggcccataaa 3781321 agcattttga cggcttcggc gacaaggctt cctccaaggc ttcctcccag aatggaaagc 3781381 ggagtcccca ataaaacgct tacaatatta tgaaggcttt caaacggtgt cgcttcaaca 3781441 atcagccggg ctgcccaaat taggaagatg acggcaaagc cggggattaa cgcgacaaat 3781501 gacttgctta ccgccggcgg gacaccgtcc ggcattttga agactaaatt gcgctggata 3781561 ataaggcggt aaatctctgt ggacaccatt gcgataatca tggcgacaaa taagcctttg 3781621 cttcccatga gcgaaagcgg aatcccgccg ccaaccatga tttctttcgt cgcgccatcc 3781681 ggcataaacg gcacttgata aggtgttgct aataaaaatg ccgcaaggga aatggctccg 3781741 gccgacaagg catcaacacc gtatttctcg gcgagccggt aggcaatgcc gaacgcggcg 3781801 acaagaccca taatttcaaa ggtcgcgtcg actgggtagg ccagtttttc agaccaggag 3781861 ctgccaaacg tttttgccat aaactcagcg tatcccggga tcgggaggtt gccaatgatg 3781921 aggaaaaagg aaccgatgat aatcaggggc atcgtgagga tgataccatc acgcagcgcc 3781981 tgcaaatgac gctgtcccgc aattcttccc gctataggca tgaccttttc ttctaagatc 3782041 tgattgactt tattcacata gcccgcccct ctctatgaca catgtccaag ctgttcagct 3782101 gatttcagca cttccgcccc attgcacgtt ccataatgga cggtattaat gacgtctacc 3782161 ggaaccccct ttgactctcc taattttttg agctgcggaa gcatgtaacg gacttgcgga 3782221 ccgagaagca atacatccgc tttatcgata tgattttgta cagaatcgcc tgaaactgcc 3782281 caaatggtat agtcttttcc ctgttcctgc gcactttttt ccatcttgct caccagtaag 3782341 ctagtagaca tgcctgctgc acaaacgagt aatatattca tgtaaaagac cccctagagt 3782401 ttgatcaatt ttgtaatgtc ctgctgttgc tatcatcata ttatgaaatc gctttcataa 3782461 acactcaggg tttttccgca ggcaacggaa aaaaggtata tacaggctgt cagctcagca 3782521 ttttttggtc aaacacatcc gaaagctctt gatatgaacg gcatttgatc agctggttca 3782581 tcgccgccgg gtcatccaaa atgctgccaa gcagtttata catgctttgt aaatccgctt 3782641 tgttctcctt ttcgacacaa agcagacaga caaattgaac tcgctgactc tcccaatcga 3782701 tcggtttttt gagcgtacaa acggcccaaa acgttgtttt cgtctgcgga acaagcgggt 3782761 gcgggatggc aacaagattg ccaaaacacg ttggcgacat gtcttctctt tcaaaaatgg 3782821 aatctatgat ttcttcatcg gcaaagccgc attcgaccac tttctgccct aaaaattgaa 3782881 tcacttcttc ttttgagcgc agatcctcct gaaaaaaaac gagttctttt tttaggtagc 3782941 gattggcttt ttccttttca tcactcagaa tagattctat ttttgtaaag tcagttccgc 3783001 ctaagatggt gttaaccttc agtactggta cagggagctc ttttttaatc ggaatggtgc 3783061 tgatgacaaa atcaattgat tcgtaggaca tttgatcaag actataatac tcagccgttc 3783121 caagaatatc gagccgcttg ccgaaatggg aacgcagttt ttcgcgcaga agctgggcgc 3783181 ttccggctcc cgatgcgcat acaatgatac agcgtttcgg cgggctttct gttttttttc 3783241 gttcaatcgc ggcgccaaag tggagagcca aatatccaat ttcgttttca tgaatctcaa 3783301 tacccgtttg ttcctttatc acgattccgg caatgatccc ggcttcaaaa gcgagtggat 3783361 aatgttcctt gatcgctgcc agcatcggat ttcgaagatt catgccgtat cggttgcggc 3783421 tgatcgccgg cttcatatgc agtgccaagc cgattttcag ctctttgtca tgcaggatgc 3783481 caagcttcag ttcacgatca acagctttga tcatggcaag tgtcagctga tcggtttcct 3783541 cttctattga aaatgtgtcc tctccgcatt gtgattgtgt cattcgtttt gtgccaagga 3783601 gatgcatggt gatgtaggcc gtctcgtctt tcggaaacgt aacggaaagc tttgattcca 3783661 gctcttttac gatggcttct gcagcctggt actccttttg atgcaggata tgatccatat 3783721 ctttcgggaa aagagaaaca tagttttccg ttctgatccg tttacaggcg atagcgatat 3783781 ggataatgag gttattcagt cccatgttgg acagagggat gcggtcgttt ttcatttttt 3783841 tcaagatggc ggaacggatg atctcaattt cttcttttgg caaaatatca gccttttcat 3783901 ttaaaacatc tatctccgtt tctctttcat caacaatgta ctccgccatg cagtacctca 3783961 tctgcacctc gtccccgcgc agcttgaagc cgtaattcgg acgtgtttcc atgacgatgc 3784021 ggtaaggcag cagacgtttc tttacttcct ttaaatccgt ttggagtgta gattttgaga 3784081 taaatagttc ttcagcaagt tcatcgagct tgagataatg gtccgccagc agcagacgtt 3784141 tcataagata ggccattctc tcctccggca ataccggcag gccctttttt tgctgaaatt 3784201 catcttgcag cagtgttctg aatacttgct cgtcatcaat gcggagcttg tagccggagc 3784261 ctcttacaga ttgtacaaag gcaccgtggc cgcttagcac accttgaagt tcctttatat 3784321 cattgcggac tgtccgcgtc gttacgttta attgcgcggc aaaaaacgaa cttgtcaccg 3784381 gggcttcagc cgccatcagc aagcgcagaa tatcacgtag tcgcccatga agcatgagaa 3784441 aaacctccta actagtagat gcagggattc agtgaatagg cagaaaggat gatgaaggga 3784501 tgcgaaatgt atataaattc tataatggag agaatggcaa gtcaatgaac atccggagga 3784561 ctagagggaa aactgaccta taaaaaaaca gccgggatca gccggctgtt ctagatgcgg 3784621 acatattctt ttgtttagac gccttgcggt ccttcatgat ttttcgaaca atcgggtaaa 3784681 tgaccggcgc ccatttgata acggttttga tcatcttttt caaagctccg attctccctt 3784741 cttttttctc aaccattccc ctgattgcct cttccttaaa catgctaacg cgacacgtac 3784801 ctgtttcccg tcacccagaa acgccatgga taatcgcgtg cctccccgct gttgtcaatg 3784861 ccgatgcgcg ggccggttga aattgcttcc ggtgtgtacc cgctttcgat gtaaagcggc 3784921 tgttccgtga tccagcgtcc gtagtcattc atcgtgacgc caagcgcttt cgtcagcttt 3784981 cctggtccgt ttgtccattc cctcggactc ctgcccggcc ttctctcctc cattaacagc 3785041 tggccttcat gcggctcaat cgccctgatt aatactgctt gcgggacatc ctcttccgcc 3785101 gcaacgacat tcagcaatgt atgggtgtgc atcacgtatg tatatacccg cccagcttct 3785161 gcaaacatga tctcagtccg cttcgtccgg cggttgttaa agctgtgggc cgctctgtct 3785221 ccagccccca tataggcctc tgtttccaca atatagcctg acgctgtgcc ttcgtctgtt 3785281 tcttttacaa gaaggcagcc cagaagcgat ggggcaagct caagagcggt tttttgataa 3785341 aacgtgatgg gcagcggatt tttttctctc gtcacgaatc gacctctcct tttaccgatt 3785401 tttgtacatt gtaccattcc cgaagcagat caaaaaaaac ggctgtttta aaatctttcc 3785461 attcagggaa tattgttacc gttcaaaaaa ggagggccaa ccattgaaag atgatcatca 3785521 aaacaagcag caccaatcaa atgcccaagg gagcgaggaa gcgttttctc ataagacatc 3785581 cgggaaaaac gagtcagagg ataccttaac gaataggcag gggcatcctg ttactgacaa 3785641 ccagaatgtg agaaccgtcg ggaatagagg gcctacaaca cttgagaact atgattttct 3785701 cgaaaagatc agccacttcg accgggaacg catcccagag cgggttgttc atgccagggg 3785761 agcaggtgca catggatatt ttgaagcgta cggaagcttc ggagacgaac cgatttcaac 3785821 atacacaagg gccaagctct ttcaggaaaa aggcaagaaa acaccggcat ttgtccgttt 3785881 ttcaactgtg aatcatggaa aacactcgcc tgaaacattg agagacccgc gcggttttgc 3785941 tgtaaagcta tatacagaag acggaaactg ggatttggtc ggaaacaacc tgaaaatctt 3786001 ttttatccgc gacccgctga aatttccgga tcttgtacac gcatttcagc ctgatccagt 3786061 gacaaacatc caggatggtg aacgtatctt cgatttcatt tctcaatctc ctgaagcgac 3786121 acacatgatc accttcttgt tttcgccttg gggcattccg gccaactacc ggcaaatgca 3786181 gggttcaggc gtacatgcct ataaatgggt gaatgaggag ggcaaggccg ttctcgtgaa 3786241 ataccatttt gaaccgaagc agggcatccg caacctgaca cagaaggaag cagaagagat 3786301 tcaagggaaa aactttaacc atgccacaca ggatctatat gacgcgattg aaaatggcga 3786361 ttatccagag tgggaagtat atgctcaaat catgagcgat gatgagcatc ctgaactgga 3786421 ctttgatcct cttgatccaa caaaactgtg gtataaagac gatttcccat ggaaaccgat 3786481 cggcaaattg gttctgaaca aaaatccgga aaactaccat gcggaagtgg agcaagcttc 3786541 atttggaacg ggagtgcttg tcgacgggct tgatttttca gacgacaaat tgctccaggg 3786601 gcgtacgttt gcctactctg atacgcagcg ctaccgtgta ggcgcaaatt acctgcagct 3786661 tccgatcaac tcgccgaaaa agcatgtcgc caccaaccag gaaggcgggc aaatgcaata 3786721 tcgggtcgat agagcagaag gacaaaaccc gcacgtcaac tacgagccat ccattatggg 3786781 cgggctgaag gaagcgaagc aagacggaaa agaccatacg ccgcatgtcg aaggtgatgt 3786841 aaagcgtgaa gcgattgaca gaacaaacaa cttcggacag gctggagaaa cgtaccggag 3786901 atttactgaa tttgagcgga acgaattgat tacgaatttg gtgaatacgc tttctacgtg 3786961 ccgaaaagaa attcaggatc aaatgattga gaatttcaca aaagctgatc ctgactacgg 3787021 aaaacgcgta gcagaagggc taaaaaaggt ctccgaaaac aacagcaacg ggccgatcgg 3787081 cacaactgaa acggaacagg ctgcaaagca ggctgaacag gagagtcatc cgtctgatcc 3787141 gtattaacaa cagcgaacag ggctttttta gaagccctgt ttttttattt ttctattgaa 3787201 acgctttcaa taattgtgtt gtacttggaa ggaaaggggt ggagagatac gatggaatta 3787261 cagcaggact tgattcctca gaaaaaaaca atcggcgctt tagatcacgc cgttttttta 3787321 tgcatggtat tttgtttctg gttttcaggc tatatttacg ttcctgtatt cagtctgtat 3787381 ttggaggatc tgcacttttc atatggcgca atcggcatca ttctcggcag ctacggggtc 3787441 acgcaaatcc ttctgcgatt cccgctcggc cttttgtcag acatcctgtt ttccttgcgc 3787501 aagcaattgt taattgccgg gttcggcttt tccgtcctca gcagcctgct ttttctgatg 3787561 tttgattctt tcttcttcgt gctggccgcc cggcttttcg cgggaatcac tgcttctacg 3787621 tgggtgatgg cgaccatttt atacgcacat tatttcaaca atggcaatgc atcaaaagca 3787681 atgggcatca tgcagttttt taccgtcatg cctcagtttg ccagcattgt gttctgcggg 3787741 ctcgccgcag cccatttagg gaggcaggtt cctttttgga tggcgctggc agcttctgcc 3787801 gcaggtctgg tgatctgctg ctttattcag gatccgtctg ctcctcccgc aaaccgtggc 3787861 accattcgtg tcaatcagta catcaaagat acattgcggc tgccaaagct gaagcttttc 3787921 accatcctgt ctatgacggc ccatgccgta ttatttatca cagtgtttgg ttttacgccg 3787981 ctttacatga atcagctcgg aatgggcgac gcggagctgc tttgggtgat gagcgccttt 3788041 ttcctcccac acgcagccgc cacattaagc tttgtgtttc tgcgctttac aagccgtatc 3788101 gcttactccg tgatgctcat tagtttcgct gtcaccgggg tctgtttgct atatgttcct 3788161 tttttagctg cattgttcac ggtttgcatc acacacgcct gtattgggct ggcgctcggc 3788221 ttcgtttttc ctctgctgct aagccatgtc gtcgaaatca gttctgcccg tttaaaaatg 3788281 tcagtgatgg ggttttacca atcattttat gcgctaggca tcttcctcgg gccccttctt 3788341 gccggaaaaa tcgcacagct tatcgggctt gcgggagttt tttatggagc cggttctctg 3788401 gcatttgccg ccttttttgt gatgctcgcg caaaaacgta acatgatcaa ttaatagctt 3788461 tcataccgcc ggaagcgcca cacagaaaac acggccagaa gcatgatgca cagaatggag 3788521 aaagtgagtg accatccgaa aaaatctgcc cgctctccat gaagaaggat atgctccgcc 3788581 tgcttgcaaa tctcagccgg aagccacttc gcaccatctg gaaatagtga aacagcaaag 3788641 gaaacggctg ctgtgagccc gatcccgcaa gccgcagctg ctccgacaga ccggaatatc 3788701 gtacttccgg caaggccggc ggtcacaata aatatcaccc aaagagcgta aaggccaagg 3788761 cttgcggcaa agcggctgaa tgatgcgtcc tcaaacagca gccggacgta atagtaagca 3788821 agcccgtatc cagctgcaaa cgacataatg ccgatcacgc tttggatgag ccatttactc 3788881 acgatataat gggctgccgt cacaggccgc gacataatca gcgctgttac cccttgattt 3788941 ctttcattgg ctacactgcc catcacgcta aagatgacca gagccatgcc aagcgtgttg 3789001 aattgagaaa gcgtgctgac catcacttca gacccggagg gcatcgtaaa actgattttc 3789061 atgccgtcag gaaggttccc tccatgtgcg atgatttccg gcatataata aatggtcagc 3789121 ggctgtgtca gcccgacgat catcatcgca atcggcagcc aaatcagctt gccgcttttc 3789181 catccttcca gccactcctt ctgcaatagc gccatcatca ccttcatgcg tgcaccacct 3789241 ttagatagac gtcttctaga gactccgttt tctgttcaaa gcgggtgacg gtcaatccct 3789301 ttcggataca gtcacttaat aatgaccggc cagcgtgtat atcaggcagc tcgaaaaccg 3789361 cttgggacgg attcttatag acaatagctg agacgtaagg cttctcttca agccaacctt 3789421 ccagcttctc tttcactgaa agggtaaaaa cgttcgtttg ctgctgttgt ttcagctcct 3789481 gtaactcgcc tttccatgaa atctcaccgt ttttcataat caccacttga tcacacacct 3789541 gttctgcatc gtgcaaaaca tgtgtagaaa acagaacggc catatgcttt ttcagctccc 3789601 gcatcatgtc cagcacctcg aaccgtcctg tcggatcaag cgcagacacc ggttcatcca 3789661 atatcaaaaa cttcggttta tggagcagtg cctgtgccag accgagtctt tgtttcatgc 3789721 ctcctgaata gcccccgatc cttttgtgcg ccgcttcgtg caaaccgaca aattccagca 3789781 tctcgccgat tttctcttgg cattttctct tcgaaaggcc ggacagtctc cccgcaaatg 3789841 tcaaaaattc atttgcggtc atccacgaat aaaaagcagg atactgcggg aggtacccaa 3789901 tcaaacgccg atccagcttt ttctctccta acagctttat ggttccagag gttggcgaaa 3789961 gcagtccggc cagcatttgc agagtcgtgg ttttgccggc tccattaggt cctaatagtg 3790021 cgacacactc attttcattc acgtgaaaac tgacattctt tacagcttca tggtgcctgt 3790081 acgatttgca taatgattca atagacagca tatcggctta cctttgcttt ctgccgacgg 3790141 tgaaaaataa aatcggcccg ataatattga tacatacgat gattgcagcc cacatccact 3790201 ttggcccgtt cgtccgctct tcttttatac agctgataag ggcaaacacc gccaaagcca 3790261 gctgtaatac aatcagcggc aaaatcattt cccaagaaat attcattgct tgatccccct 3790321 tttcttccga tccggcctaa tgacaaaaaa gtaataacaa atcagaggca tcggtgcttg 3790381 aatcaatccg acaatccccc aaacccatgc catgtgatta cgttttttcg catcaataaa 3790441 taaaaagatt ccctgcgcca atacgatgag acaagccgca accgttatga taatttctgt 3790501 ttgtgtcatc cgcgtttcac ctcgcattcg ccgagatgcc tttttttctc agccgcaatc 3790561 aaaatcggca gcaccgcaag cacacaaacc tgaagcacaa taaacacagc aggagcttga 3790621 gtgaaagcta agattgcagc actcacaacc atcagcgcgc agaatacaaa taaaatgatc 3790681 tcttgaagaa gtttttttct gtattcagct ttcatttgtg acagctggtg aagcagttct 3790741 ttttgattcg gtatagaggg attggctgtt tgatcaattt ttttccattc tgactttaaa 3790801 tgatcagaaa gcttttcttt attcatcatc ccactccttt ctgatttgct ggagcccttt 3790861 atgaactctg gactttacag tgccttcttt gatttgaagc atcaccccga tttcagcgta 3790921 ggtatagccg tagtaatgcc ttaataaaac cggtgtgcgc agtttagggt ccagctttga 3790981 aaacagatcg agcgtttcgc tccactctgc ccctttcgcc gacacgtccc acttgatctt 3791041 gcggattgtt tcctccgtaa ctgtctgatt ccgtttccat tctctctttc tctttttctg 3791101 gtgatcgaga tagagccgcg atgcaatgga gatcagccat gtggagaatt ttgaacggcc 3791161 ctgaaagctt cttaaatgga tgtacccttt cagaaaggtt tcctgaacaa gttcctcgct 3791221 gagatcgggg tgaagggaaa gctttaacaa gtatttatat aagaaagaat agtgatagtg 3791281 gaaaagggct gtaaacgcct cgtcgtttcc ctctttcgcc tgctggatca gccgctgttc 3791341 ttcttgtgta tccaatgacc gtgatccccc cttttttgtt tttctgcctt atgagacgac 3791401 accggattca aaagcgttca tcttttttac aattcttttc agccattgac agatcaggct 3791461 tcccggccgt ttggctgcat atccttattt gtaaaccccc ttatagtctg ttaagctatg 3791521 actttatgtc gatttcaaaa aaacatccaa tatggaggac gatgcattga aagtagaaag 3791581 gcgaacgatt gaatatattc cgaatgaaga aagacatggt aaagcgaaag atttatttcc 3791641 cgtatggttc ggggctaata tgcatatcac cacgttagtg accggcacga ttcccgttgc 3791701 aatgggactt aatctgtttt ggagtgttgc cgctattatt tgcggaacct taatcggtgc 3791761 catatttatg gcttctcatt ccgcgcaagg ccctcagcta ggcatcccgc aaatgattca 3791821 aagccgtgcc caattcggcg taatcggagc gattcttccc ctcttcttag tcatgtttat 3791881 ctaccttggt ttcttcgcaa gcagcacgat tctggcggcc ggaaccttaa gcagctttgt 3791941 tcccatcccg ggatcatgga gcattatagg cttaagtgcc gtatgttttt tactcaccat 3792001 tttcggccat gatttgattc acaaaatgca aaaaatcctt tcttggacct cttttgctgt 3792061 attttttgct gcaacgattc tcatttttca attgccgatt ccggcaggca gctggatacc 3792121 cggagcgatt gatctgccaa ttttcctagt ggcagtcagc gcagttgcga cgtggcagct 3792181 tgcctacgcg ccgtatgttg ccgattattc aagatatctg ccagttaaaa caccggcttc 3792241 aaaaacattt tggtacagct atgcaggtac atctgtcagc tccatctgga tgatgctgct 3792301 cggcgcattg ctgacaacct cacttcctga ctttacggca aactcaggca gccagattgt 3792361 ccaattgttc ggtcccttct cgtttattat gctgatcatt gtgctatttg ggcaaatggc 3792421 aatcaatgtt tttaacctgt atggggcttt catgtccacg acaacaacgc tggagccgtt 3792481 tctgaaatta aaagtcacgc ccaaagtcag aatcatcatg atcctgggtg tcacgcttgt 3792541 cggcacagtc ttaagcctac tgggacagag caattttatg gaactgtttt tgaattttat 3792601 ctttttcatc agttatttct taattccgtg gacggcaatc aatttagtcg attactactt 3792661 cgtccgccac ggaaagtatc aagtcaaagc catgttcgac gtaaacgggc cttatggaaa 3792721 ggtcaattgg atcaccacaa ttgcgttcgt tctgtctatc ttgctggaaa ttccgtttat 3792781 caacacaagc ttttacatcg gaccgcttgc caaaatgttt ggcggcggag acatcgcatg 3792841 gattatcggc ttggccgtgc cttctgtgct ttactatgta ttaatgaaac cgcgtctgaa 3792901 aaaacgggcg gggtatcaag aaaagctgtc ttctctctga agacagcttt tttatcattc 3792961 aaatcgtttc cacacgcggg gcaggatgtc agatagctca tgagcgagca acgtatgagc 3793021 ggagtgctcg tccgtccaga gctcggcgca cgcaccatgc aaatagaccg cgtttaatac 3793081 ggcgtgcttt ggatcttcat ggcagcagag catccccaat atcatgcccg tcagcgtgtc 3793141 accggttccg cccttggcga gcgccccgtt tccggttgga ttgagccagc agtctccatc 3793201 aggaaacgcg atgacggttt ggtttccttt taacacaatg acagtctgca gctgagccgc 3793261 ccattccttt gcatattccg ctcttttttt ctgcaattcg ttcacgggca cccctgtcat 3793321 tcggaaaaac tcgcccgggt gcggcgtgag gatgacgggg ccctcccgtt tcggatatgt 3793381 gcgcttcgcc agcgctccgg catccaaaat aacaggacaa tcagccgtaa gcacatgatc 3793441 gactgcctgc tgtacgcttt ccgtttgcgg aaggcccggt ccgatggcaa tggcccggta 3793501 cgtctcttca agctgagcat ccgccgcctt tttccagccg tcacgccaat aggtcgcctc 3793561 gggcaaaaca ggaacaatta gcgggattac gttttctgat gtaccgatga caagcttgcc 3793621 gagaccgctc cgcatggccc caagccctgc aagcagcgct gctcccggca tgtcgtcact 3793681 tccagccagc agcaaagccg taccgtacgt gcctttatgg ctctccgcat ctctttcagg 3793741 aagcgtggcc cttacatgct cttccgtcca aaatggaaca ttcatctcta tccctcctct 3793801 gctttctttt cctatttttc ctgtcccttt tctttttcaa acaaaaaaga cagcctttta 3793861 gggctgtctt ttattttaca ggaacatcaa ggtgatacag gcggcgatat cgttcgtttg 3793921 ccgccagcag ctcctcatgg gttccttcca tttctgtttt gccgttttcg agaaatacga 3793981 ttttatcggc tgcttccact cccgcgagat ggtgtgtaat ccataaaatc gtttttcctt 3794041 tcagcacctc aaacaccgtt tccatcaatt cacgttcggt aataggatcg aggccgactg 3794101 ttggctcatc gaggatgatg atcggtgtat cctgcagcaa aatcctcgca agtgcgatcc 3794161 gctggcgctc tccaccggaa aaacggatgc cggtttcttg tacagaggta tgatatccgt 3794221 caggcaatga ctcaatgtag tcatgcagct tgacctgctt tgcggcgcgg cgcacatcct 3794281 cgtcgcttgc ttctccgttt ccgagcctga tgttgttcaa aatgcttgta tcaaacaggt 3794341 gcggtttttg atttaacacg gccaccgcat ccgcaatctg atcctttaac agcgctgtct 3794401 ccactccgtt taacgtcaca gaaccggagt ccggtttcaa ggcgccttcg attaatgcaa 3794461 gcgatgttga tttcccagag ccgcttcggc cgagcagcgc cattttttct ccttggcgca 3794521 gcgtaaagga aaagttgtgc agcacttggc tgctgttgtc ataagaaaac gtcacatcac 3794581 gaaaggccaa ggtgacatct tgaagatcga gaatttgatc ccctgattca gtttgtgacg 3794641 cctccggctg aggagccaca ttgttcatgc gtctgataga atcctgatag cccggcactt 3794701 cgcctaaggc atccgaaagc ggcaaaaagg cttccgtcaa cggaaacacc actagcacaa 3794761 aagcggcaat catcgtttta gcgagctcgc cgtccgcttg ctgtcccgct gtccaaaaca 3794821 gcatcagcaa aataaggcca gcgacaaggc attgcgcagc aaagtcccgc catcttgtaa 3794881 agcgttgttt tttccgttca agctcaaacc aatcacgttc ctctttttca taagcatcaa 3794941 taaaagcatg ccggcgtccg ctgaacatcc agtcgctgac acccatcaca gcatctgtca 3795001 gacggctgta cagcacattc cgtccgcttt tcagcttcgc attcttcgct ctcgtcacga 3795061 gcaaagacac aaccggaaac aatacaacaa gaacaaacaa atacagcgca agcaatatgg 3795121 caaacggcca agagaagaag ccgagcgcta tcactgacac agcatacagg agcaaggctg 3795181 agatcgcagg aaaaatcgtt tttaagaaag catcctgcaa atgctcaata tcctcagaca 3795241 aaatgccgag catatccccc gtgcgaaaac gggaacgcag catcaaagca cccggctcaa 3795301 gcatattgta aaggcggacg cgcatgtcag atacgatttt caaaatgatg tgatggccga 3795361 cgagccgttc cacatatcgc gacacagagc gcgcaatccc aaaggtgcgc acagcgacaa 3795421 tcggcacata aatgagcaga atgttttccg gccttgtcgc cgctttagaa atcaaaaaac 3795481 ctgaggtgaa catgagaaaa gcagcagaaa aaatcgtcac cgcacccaaa aagataacca 3795541 gaacgaacag gcgggcattt tgcttgatat acggcaaaat ccattcttct ttcttcatgc 3795601 tctttccccc agttgtgcct tcacgagttt ggtatacaca ccgtttttct ccagcagttc 3795661 attgtgagtc ccaatttccg caaccctgcc cccgtcaagc acgataattt cgtccatatc 3795721 gagcatccag tgaaggcggt gagtcgcgag aaagacgagc ttatcctcaa ataaatccag 3795781 catcgtttct tttatttcat attctgtttc gatatcaaga tgggcggtcg gctcatccag 3795841 cagcaggatc ggacggtttc ccaaaaaggc gcgggccagc gcgacacgct gtgcctggcc 3795901 gccgctgagc gcccggccgc cttccccgat ccgcccctct aatccgtcag gaaggttgtt 3795961 caccagctcc gtcagtcccg ctgaggcagc agcacgtgtt gtatcctctg ccgaagcgct 3796021 tggatggtag aagcgaatgt tgttgccaag cgtatcatca aaaatgtacg gatgctgggg 3796081 aatgtaaaga aggttcttct gccagctgcc gtcctgcaaa tgggaccggc ttgtaccatt 3796141 aacctcaatc atcccgccat ccggctctaa aaatccgccg agaatatcaa ttaatgttga 3796201 ttttccggcg ccgcttgcac cgataatgcc gatttttttc ttgcctttga atgagagatg 3796261 aatatcagac accgaacggc cgactgacac gcctgacagc ttcagctcat cctgatcgga 3796321 ccaagcttcg agctgaagcg gcgtctcttc tttaaaacca ggctgcgaca aaatctcttg 3796381 aatggttttt cctgcttcct ggccgttcag cgttgcatga taatcattcc ccacttcccg 3796441 caccggcaaa aaatactcag gcgccagaat aagcgccgtt aaagcagggc caagcaaaat 3796501 atcgccgtca atgaggcgca ggcccagaaa tactgcgact gtcgccaccg acagcatcgt 3796561 gaaaaaatcg agggcgaatg atgacaaaaa cgccacccgg agtgtgctca tcgttgcctt 3796621 gcgataccgc tcactcacat agaaaatatt tttgctgtgt gacttgctca aacctaggaa 3796681 acgcaatgtc tccagcccgc gaagagaatc aacaaaatga ttggaaagtc tctgatagga 3796741 tttccactga cgatccgctt ttctctgcgc gacaaggccg aggagaatca taaagatgat 3796801 cagaatcggc atagcagcga ctaaaatgat ggctgatgtc cgatcctgaa aaaacacata 3796861 aatgacaact gccgcaggca caatcgccat gctgaccatt ttcggcagaa acagctccag 3796921 gtagcggcgg aactggctga tgccttccat cgccagcgtc accatttgcc ccgtcccctc 3796981 tttctttgca aagcgggggc ctaatcggaa cagctgatca agaaaacttt tcctcaaatc 3797041 tgctcctgtc cgggcggcgt attgatagac gattttctgt cgcgccaccg tcatcccgtg 3797101 ccgggcgata aaagcgatga ggaaaaagcc gatcaccggt aaaagggagg taatgccctt 3797161 cccgttgaac agtccggtta cggcctcact cagccactct gcctgcataa taatggcggc 3797221 tgtctgaatc aacgttaaac aagtaatcaa ggtgagaatc cgcttcattc ctttatatcg 3797281 aaacaggtct tttcccatta ataagtcata ggctccttat ggctgacgcg cttccggaag 3797341 acataatagc tccagatctg gctgccgatg acgaacggca atagcgttaa tgctgcaatt 3797401 gacatgactt taagcgaata atctccagaa gaagcgttag ctactgttaa atcgtatgcg 3797461 ctatgaagcg agctgaccat tacacgaggg aatagggaaa taaagatcat tcccacggtc 3797521 agcgccagac cagcgcctgt catcccaaat gtccagccgt cttttttctt acgaataaat 3797581 acagccgcga gcataaagca gatgacaatc aaaacagcga gcggaatggt aatctcgccg 3797641 cggcgtgtaa acatgtctgt ctgatacgca gaaagggccg cgaaggcaag aaccgctaca 3797701 aaaacaacac ccattatctt ttgcgccatt ttccgggcgc ggttttgcaa atcaccaatc 3797761 gtacgcagcg tgataaacat taatccatgc tggaagcaaa gaagcgttac cgtcacaccg 3797821 ccaagtatag aatatacatt gatataatca gatacatgtg cgtgaatgtt catgtcggca 3797881 tcaatcggca tcccgcggaa taatgtcgtg aacagcacac caagcacaaa cggaggaatt 3797941 agactgccga aaaaaacgac ccagtcccaa acctttaccc attttaaatg atccaccttg 3798001 ccgcggaact caaacgcgac cccgcggccc attaacgcaa gcagcactat gacaaacgga 3798061 atgtaataac cgctcagcat cgttgcatac cagtttggga atgccgcgaa aatggcgcct 3798121 gcgccagtca aaagccacac ttcattcgcg tcccagaacg gcccgatcgt gttgatcagc 3798181 actctgcgtt ctaattcatt atggccaaga aaacgggtcg ccatgccgac cccgaaatca 3798241 aagccttcca aaaagaagaa tcctacaaac aatacagcaa cgagtataaa ccaaagatca 3798301 tgaagagatg ccatggtata cctcctgact aaatggatct gttgatacag gcacatcatg 3798361 atgattatca tgctccgcac cttttttaat ctcacggata aacaagaaga caagcagtgc 3798421 accaagaatc atgtacatca caccgaatgc gatgattgag aataacaagg aacccgctgt 3798481 tacgttaggc gacacagatt gagcggttgt cattaacccc ataaccgtcc aaggctgacg 3798541 tccgatttct gtcataatcc agcccgcgga gtttgcaaga aacgggaagg aaatcaacgc 3798601 gatcatgatg cgcaaatacc atttgctgtt ttcaagcttt ttacggcggt ttaaccaaag 3798661 gccgcctaac gcagcaagaa tcatgacaac acctgctcct accatgatgc ggaagctcca 3798721 gaatgtcgtt ttcactggcg gaatgtagtc gccttttccg tatatttttt cgtactcagc 3798781 ctgaagggtt ttcatccctt tgacacttcc gctgaatttc tgataagcca agtagctcaa 3798841 ggcataagga actttgattt catttgagct tttttcattt tttgtatcga tcgtcgcaaa 3798901 agcggtccaa gcagcagggt caccgctgtc ttcccatagg ccttcactgg cagccatttt 3798961 catcggctgt gattccatca agtgctcagc ctgcatgtgt ccgctaaggc cgacgccaag 3799021 accggcacaa agaccgacga tcattgcgag tttaaaagat tgcttaaaga acggcacttc 3799081 ttttttcttc agcagtttaa aagcactcac tccggcaata aagaaagctc cagtggcaag 3799141 cgcaccgaaa ataacgtgcg ggaattcaac ccaaagctga gggtttgtaa tcaacgcgcc 3799201 aaaatcattc atttccgcgc ggccgttttt gatcgtaaag ccgaccggct cctgcataaa 3799261 ggagtttgct gttaaaatcc agaaagatga catgatcgtt ccgaatgata cgagccatat 3799321 gcagagcgcg tgaattttct tcggcaggcg gtcccagcca aaaatccata atccgataaa 3799381 aatagattcc atgaaaaacg ccaataatgc ttcaatcgca agcggagcgc caaatacatc 3799441 tccgacaaaa cgggagtaat ctgaccagtt cagtccaaac tggaattctt gcaaaatccc 3799501 cgttacaaca ccgactgcga aatttattaa gaataagtgt ccccaaaact ttgccatttt 3799561 gagatacagc tcatttttct ttacaagata aagagtctcc atcaacgcaa ccataaacac 3799621 aagcccgata gacatcggca caaacaagaa gtgaaacaac gttgttgatg caaattgtat 3799681 gcgggctaat accaattcac tcatgctttc tcctccattt ccggttaaaa ctgttaattt 3799741 gctcactact tcacaaatag aaccgagact ttgatcagta attcacaaaa tagacgaaaa 3799801 aaatattgct caatatttca caaatgtgtc aaaaagtcat ccaatatgat gcaagattgc 3799861 cagactgacc aaatgacaca atctctgact ggttcatatt aagtacttta caacgattca 3799921 tttcaaaaat aaagcctaaa atacctaaaa agtcccgcac tatgtgacgg atttttgtct 3799981 attttgttgc ttatttatgt cggctgctag gataaatgac cctttattat cgtacatcaa 3800041 cacatcgttc cttgcgaaca aaatgcttgc ccccgcccca gcactcgagt ctcagcattc 3800101 cgtcttaaac cgattttagt cagaatgcct cttttcattt gaaccggtaa gaggagaaaa 3800161 gttgaatagt aaatttttaa tatattaata atttcaattt tttagtatac ttaacatagt 3800221 gaacaatttc actgcatcaa gaatagggga ggtttttcaa tgggagagct tcaaacacac 3800281 atgcaattgc aaacggatac aattcacgaa ggggttcgaa aagagaattg gtttgcgaaa 3800341 gccatgaata taaaagtagg catcataccg cttcctgtgt atgccttgct gtttatatta 3800401 atcactgttt ttgttatgca tcacgatgta aaaagtgaca ttttgacatc cattgccgtc 3800461 atggcgtttt tcgggtttac ctttgcccaa atcggcaaat cgataccgat tgttcgttct 3800521 atcggcggcc cggccatcct agctactttt attccgtccg ctgtcgtgta ctatcacctg 3800581 ctgcctaatg atatcgtcaa atccaccaca gaatttacag aaaactcaaa ctttctatat 3800641 ttgtttatcg ccggtattgt cgtcggaagc attctcggca tgaaaagaga aacactcgta 3800701 aaagcattca tgaaaatctt tattccgctt attgtcggtt ctgtcacagc cgctattgtc 3800761 ggactggctg tcgggacatt gctcggactc ggatttcagc ataccctgct gtacattgtc 3800821 attccgatca tggctggagg agtcggagaa ggcgctatcc cgctgtccat cggatattct 3800881 gacatcatgc ccatttctca aggggaagcg tttgcacttg ttctgccatc gattatgctg 3800941 ggcagcttgt gcgcgattat tctagcggga ttgctgaacc gaatcggaaa gaaaaaaccg 3801001 gaatggacag gcaacggcaa agtggaccgc tccgaagaag agtcccctgc gctggaggaa 3801061 tctcaaagcg gacagcaaat gttcaacctt tctttatttg cgtcaggcgg tatccttgct 3801121 gtttctttat acttagtcgg catgctcgct cacgattttt tcggttttcc ggcacccgtt 3801181 gccatgctgt tactggctgt tctaatcaag ctgttcagat tggtgcctgc ctcaattgaa 3801241 aatggcgcgt ttggagtgtc ccgcttcttt tcaacagctg tgacctaccc gcttctcttt 3801301 gcgattgggg tatccatgac gccgtgggac aagcttgtcg ccgcttttaa cctcagcaat 3801361 attatcacga ttctgtctgt cgttgtgacc atgatggccg ttggcttctt cactggaaaa 3801421 tggctgaaca tgtatccgat tgaaaccgcc attattaatg catgccattc tgggcaaggc 3801481 ggcacgggtg acgttgccat tttaagcgcc gctgaaaggc ttgagctaat gcctttcgcc 3801541 caggtgtcta cccgcatcgg gggcgcgatt acagtatcct taaccttatt gctgctgcac 3801601 cagttttatt gatccccgca agcaagttct tcgtcaaacg aaagagcttg cttttttgca 3801661 tgtccatgtt tttgcaagtt cccatcccat gctatagtaa tagttggaaa tactagatag 3801721 aaaggaatct ggcatgccta tgggaactca tctatttctc tttatgcttc tcgggctggg 3801781 attttatttg atatcagccc tagctgcaaa actcattccg gccatagact tctggattga 3801841 tattgttcta tgggtcggcg ctgcggctta catcttctct catctctcat tcatggacgg 3801901 cattgtctca ctcgcgacaa tgttctactg ctattggacc gcaatggatc tcattgtttc 3801961 agagcgtgtg gaaaaacctt cgggagactg gcaggaaatc gagcttgcca aaaacaaaac 3802021 acgcctcctg tcagacatta cgctgaccgc cattgtgttt gcaggggctg tcattttttt 3802081 catctatgga cctgacacaa gccctctcaa atatgtgatc cttctcggaa tgatctccgg 3802141 cggaggggca cttgtgaagc gaatactgaa tgtttttagc gtaaaggttt tttattcagc 3802201 agccttagaa aaattgcata tcagctcaca ctatgaaacc cgtacatacc cgctttccga 3802261 tttgaagaac attcagcttg aatcaacagc agatctctta aagctccatc cgcttctgac 3802321 gatgtattca tcccgtttag atttgacaac aagctttcag caagtcatta aactgtctct 3802381 tcccggcgaa acactgtttc tgacggtgaa ggaaccgcaa aaatggaaaa caattcttca 3802441 ggaatacaca gatgcagaaa acaatgtgga caatgtgatt tctgttttgc cgttttatca 3802501 tcgaaaaaat gtgaagcggc tgctcggtaa gctttatttt gccgccagcg taaaaggggt 3802561 atccgcttac gccttattgg tgctcgcgtt atacgcatta cacgcctctc catgggtcat 3802621 ggctgttgcc gtaatcctat attgggtatt caacatgtat atgtcagacc gtgtgttgcg 3802681 ggcggcgatg gacgccaagt cttgtcatca tccgcatgta caggccgcgg ccgataagat 3802741 tttcagatcg gccggcattt cccatgtccg catatacgaa acggagagtg atgattacaa 3802801 cggaatggca gtaggcatga atgtcgggag gtcaatggtc atcctgacaa gcgccacact 3802861 aacacttcca cagcgtgtca ttgaaggcat tctggcccat gaggcgattc atatcaaaaa 3802921 acgtgacgtt ctgtcatcac agcttttgcg ttttctatat cttggagctg tcgtggggat 3802981 tttcctcttg tttgagcagc atatcaccca tcccgaggcc cacaaaattg cgctttgggc 3803041 tttcattatg gcaatcatta tcctattcca gctctatcaa tccttttgtt cacaatggat 3803101 ggaggtgcgt gctgacaacc ttggcgcatc attgctggac ggcggttaca aacaaatggc 3803161 tgaagccttg agaatcttgg cggttcggca agatgaggat atacagaaac aaagtgccta 3803221 tagctctgaa gcaggtgaag acgagcttca aattgattct ctcacccgtg ataaaagctg 3803281 gtttttcaga ttgattgatt ttcagttcgc tcctcatcct cctatgtatt ggcgtgtcgg 3803341 cactttattg tcaaacaaag gacatggggt gctaaagcgc tggctcagag accgactgaa 3803401 agaatcgatc actttgaaat gaaaccggtc agcgtttcat ccgtataaca gatatggtga 3803461 aaaaagggag tgacgcgaag tgattgtgat catcttattg tttatatcta ttattgtttt 3803521 tctttcagtc attcagccgc agccctcgaa aaacaaaagc cgccagcagg cggacagcgg 3803581 gtatttcggt tattcagatc atagctcaca ccatgatgga tgcagcagtg acggaggttt 3803641 cagcgattcc ggctgtggcg gcggaggggg cggcgattaa acgccgcctt tttttatttc 3803701 attgattcga tgtacgcacc aaaagccgag cctgacatgc ctggggacac gcgcacacga 3803761 tggagggcat acattccctg gtctctcgaa gccgcgcccg gttctgtcgt cacgcccatt 3803821 tgatagcctg ttttttcagc ggccttcagc gtctcctcat tgtagcgccc taccggatag 3803881 ctgatgatgg tggtttgctg atgaaacatg ttgtcgaaca gctttttcga atcagccatc 3803941 tcactttgct gctgttgagg cgttaatccg ttcagctcaa ggtggtcaat cgtatggctt 3804001 tcaatcgata tgccgtgctg tgccatttcc ttcatttgtt cctctgtcag atggtgctta 3804061 tgtccgatcg atttgccgat cataaaaatc gttgccttca tcccgtactt tttcagcacc 3804121 ggatacgcat cttgataatt gtcggtgtac ccgtcatcaa atgtgatcag cacgcacttc 3804181 tcactcggtt ttttatcctg cgtcagcatg agagatgcct ctttcggcgt taatgtctga 3804241 tagccgttat catgaagcca cttcatatgc gcctcgaatt ctttctttgg cacacggagg 3804301 ctgtttcctg aagaaatgct gtggtacatc aaaatcggca gctttgccgg tttctctgtt 3804361 ttgatccatg cggatgtatc gtcttctttt ttctgaactt gtactgcctt tttttccggt 3804421 ttcttttgtt ccgcttttgg catcggctgc tctgcattcg cctcttgatc agcacaagcc 3804481 gcaagagcca aacagctgcc caaaagaaag atgcttaaaa acaatcgttt catcgttctc 3804541 ctgctttctg tctatttctt cctccttttt catcggtttg attctgagat tttcaatagc 3804601 aaaaaaccgg acatgtctcc atgtccggtt tttttgatct tatcggattc tcacttctgt 3804661 ctcactgtca aagaaatggc ctttattcat atcaaatgca accgtcagct catcgcccga 3804721 ttgaatatcg aggcgggcgt cgatccgcgc aataaagtct tggttgtcta tctgcgaata 3804781 aatcataatt tcagaaccga gcagctctgc aacattaatt ttcgccttaa tcgaagagtt 3804841 cttatatgat tccacgacaa tcaattcatc atgtatatcc tcaggacgga tgccgaagat 3804901 gacctctttg ccgatgtagc ctttttcacg cagcactttc atttttcctt ccgggacggt 3804961 taatgccgca gaaccgattt tgattaagcc atccgtgagc tttcctttga aaaaattcat 3805021 cgccggtgat ccgataaacc cgccgacaaa gacgttttca gggaattcat atacatcctt 3805081 cggcgtcccg atctgctgaa ttttcccatc tttcatgact acaatccgtg tcgccattgt 3805141 cagcgcttct gtctggtcat gcgtcacata aatcgttgta gtctgcaatc tctggtggag 3805201 cttaatgatt tccgcccgca tttgcaccct cagcttcgcg tccaggtttg acaaaggctc 3805261 atccatcagg aacacctttg catcccgcac gattgcccgg cccagcgcaa cccgctgtct 3805321 ctgtccgcct gacagcgctt tcggtttacg gtgcaaatat tcctcaagcc cgagaatttt 3805381 agcggcttct tcgactcttt ttttgatttc aggcttcggc attttccgaa gcttgagccc 3805441 gaacgcgata ttatcgtaga ccgtcatatg cggataaagc gcgtagttct gaaataccat 3805501 cgcgatatcc ctgtcctttg gcgctacatc attgacccgt tttccttcaa tataaaaatc 3805561 acctttcgaa atttcttcaa gtcctgcgac cattcgcagc gtcgttgatt tcccgcagcc 3805621 ggacgggccg acgaatacga taaattcctt atcggcaata tgaaggttaa agtcatcaac 3805681 cgccggttcc ttctgatcat aaaatttata aatgtgctcc atccgcaatt cagccatcta 3805741 acatccccct ttgttattgt aaacgctttc ttatattgag tgtaacagca attccctctc 3805801 gctaaaatgg gcagcgttca taaaatcacc cagccatttt tcgtgcatat ttccaattta 3805861 ttctgaactt tcattttgca ggcagataaa ataggcaaga agcgcgcctt tgtacgattt 3805921 gatatctatc cctgaccgct caataaattt atcaatccga tattgcaggc tgttgcgatg 3805981 cagatgcagc tttttcgctg ttaatgtgac gtttgagttg ttttcaataa acagcttaat 3806041 ggtcttcctt agctcagatt cacttccaaa taaaagctca gcttcttcag agagcagtgt 3806101 ttccagtttt tctttttctg tttctaataa tagaaaagga aagatcatct caaaggtcac 3806161 actctgcacc tgaggcagcc gtttttcagc aaacaggaaa tacgcctgtt cacgagcgta 3806221 atgttttcgc agacactcat ccggctcgta aaatcttccg gcgtaaaaac ggacactgaa 3806281 gtagaaatca ctttcaagaa ccttagcgag cgattccagt tcgtccttct ccgccgccgc 3806341 ttcactttcc tgctcgacaa tcacacctct gtcctcatgg atccacacaa tcacaaaaga 3806401 caccggccaa aaatggcgaa ccgcttccgt aaaggacgtc ctttctattt tgccgaataa 3806461 atgaaagtga acaaatctcg tccgtttctt tatatacgcc ggcaattccc ctctggaaaa 3806521 aaggaacgaa aaccacttgt tttcctcagg tgatttcata gacagttgat tgccctcatc 3806581 cgcaggcgtc aaaaatgact gcagcaccaa tacttctttt tcactgatct ctgttttcgg 3806641 aatggagata tatctctgat tgctctcatc aaaaaaacat agacagcctt cccttatgca 3806701 aagctcctca gacacaatcg aaccgggata aatagccagc agcgatttca tagagtctcc 3806761 tctcttatgt aaggatctgt atattcagta taaggcgaaa cacacatgtt ctccactaaa 3806821 aaagagtata tccggtatag atagacgaga aactgaaagg gaaacctcat tcgtttacat 3806881 attggcttca gcggaaatag aagaagacat gcaggaccaa aggagggtca tcttatgagt 3806941 ttcgaaacgt taaacaaaag ttttatcaac ggaaaatgga ctgggggaga aagcggacgt 3807001 acggaggaca ttttgaatcc gtatgaccag tctgtgatca caacagcatc tttggcaacg 3807061 ggcaaacagc ttgaggatgc gtttgacatt gcacagaaag cccaaaaaga gtgggccaag 3807121 agcacgacgg aagaccgaaa agccgtgctg caaaaagcgc gcggctattt acacgaaaac 3807181 cgtgatgaca tcattatgat gatcgcccgc gaaactggcg gaacgatcat taaatcaaca 3807241 atcgagctgg aacaaacgat tgcgatttta gatgaagcca tgacgtatac tggtgaatta 3807301 ggcggcgtca aagaggtgcc atccgacatt gaagggaaaa ccaataagat ttaccgcctt 3807361 ccgctaggtg tcatttcatc gatttctcca tttaatttcc caatgaatct atccatgaga 3807421 tccattgcgc ccgcaattgc gctgggtaac agcgttgttc acaagcctga tatccaaact 3807481 gctatttccg gcgggaccat cattgcgaaa gcgtttgaac acgccggtct tcctgccggt 3807541 gtccttaacg tcatgctgac ggatgtaaag gaaatcgggg acggcatgct caccaatcca 3807601 atcccgagat taatcagctt tacagggtca acagcagtcg ggcgccacat cggtgaaatc 3807661 gccggtcgcg ccttcaaacg aatggcactt gagctcggcg gcaacaatcc atttgccgtt 3807721 ctttcagatg cggatgtcga tcgtgctgtg gatgccgcga ttttcggaaa atttattcac 3807781 cagggacaaa tctgtatgat tatcaacagg atcatcgttc atcaagatgt atacgatgag 3807841 tttgtagaaa aattcaccgc ccgtgtcaaa cagcttccgt acggcgatca aaccgatccg 3807901 aaaaccgttg tcggcccgct gatcaacgag cgccaaatcg agaaagcgct ggagatcatt 3807961 gagcaggcaa agacagacgg cattgagctt gcggttgaag gaaaacgcgt cggaaacgtg 3808021 ctgacgccgt acgtctttgt cggtgcggac aacaacagca aaattgccca aacggagctg 3808081 tttgccccaa tcgcaaccat tattaaagct ggcagcgacc aggaagcgat tgacatggca 3808141 aatgatactg aatacggcct cagctctgcg gttttcactt ctgatttaga aaaaggcgaa 3808201 aagttcgccc tgcaaattga cagcggcatg acccatgtca acgaccagtc cgtcaatgat 3808261 tcgccgaata ttgcctttgg cggaaacaaa gcaagcggtg tcggccgttt cggcaatccg 3808321 tgggtcgtcg aggaatttac cgtgacgaaa tggatttcga tacagaagca ataccgcaaa 3808381 tatccgttct aaatgaaaaa atccctctgt ttcaagtaca gagggatttt tctttattta 3808441 gatatatcca caaacccttc gccaaacaca tcgcgtacgt catgtacgat cacaaacgct 3808501 tttttgtcgc agcttctaat gatttttttc agcatagaca gctcctgttt gttaatgacg 3808561 atatacaaaa tctcttttga ctggcccgta taatttccct tccctgataa aatcgtcacg 3808621 ccccgatcca tcaaggtatt tacctgctct gcaatctcac tcttattttc tgaaatgacc 3808681 gtaatggctt ttttcgtatt caaaccttca ataatgaagt ccatcacttt ggtaccgata 3808741 tacagcatca cgatcgtaaa catcattttt tctgcaccaa taataaaata agagctaaat 3808801 actacgatta aatcaaaaaa caagagtgca tagctgatat tccagtctaa atatttatta 3808861 gcaattctgg ccagaatcgc ggaaccggcc gtcgtcccgc cgacccggat aatcatgccg 3808921 atcccgactc cggcaaatac acctgcgaaa atcgtattaa tgatcaattc atcagacgga 3808981 atgctccacc catgtgtcag atgaagaaaa agcgaatttg ccgcaaccgc aatgatcgta 3809041 taaaccgttg tttttccatc aagaaacttg tagccgatta aaagcaaaaa cgcatttaag 3809101 ataaagttcg tgacaccagg agaccattga aacagataat acaaaatcag cgtaatccca 3809161 gtgactccgc cttccccaag atcattggga atcgcaaata aattaaccgc aagcgcgaag 3809221 aaaaaagcgc caatcacaag cataagtaca tccagcattc tctttttcat cacgaaaaca 3809281 ctccttttca ttgttctgtt ctagcaaata aaaaaaccca ggagaacgct ctcgaaaaag 3809341 agcagaaact cctgggcttt tatcccaccg tgtcataaca gccaagctgc tatgtgtttt 3809401 ctctcggtca cagtccaatt tgcattgcgg aaccctagaa aaccactgtt tttatcatat 3809461 ccttttcact ttccaatatt agcattataa gggacggttc gaattggttc aaggggtatt 3809521 tgcggagttt tcatcagata agctggaaaa aaatacgatt tatctattaa aaaagaacag 3809581 atataaccga taagaaaaaa agcatatatt ttacaagcga atgtaactat aaatgataat 3809641 aattataaga aattcataat tttatattga ctaagagaaa taatataggc attatagtac 3809701 atatgtttcg tacattttat tacataggag gaaatataat ggcaggaaaa ctagtaccct 3809761 gtaaagcttg cggtcaagaa attgcaaagg gtgtaaaaaa atgtcctaac tgcggtaagg 3809821 atcaacgtaa cttttttatg cgacataaaa tcattacgtt tattctcgca gttgttgtca 3809881 tcattattat cggtaatatg attggcggcg gaggcggctc agaagccact tccaaaacat 3809941 caagcagcag caaagcagaa actgaaaaaa catacaatat cggtgatacc gtaaaaactg 3810001 aaaaaactga agtgacggtt acgaaggtag aggacagaga tactgtcggt actcaatatg 3810061 ttgaaaagaa agcatctgag ggaggtacaa ttgtagctgt tcaatataca attaaaaacg 3810121 tatctaaaaa gccgattagc tctttttcaa ttccaactgt taaattagtt gatgctgatg 3810181 gtacttctta tgattctgat attgatgctt ctgtaaacta tgcaactgag acaaaagttg 3810241 ataactctaa aattttgagt gatctaaatc ctaatattaa agtaacaggt gtaaaagcat 3810301 ttgaagttga caaggaagct tatgcaaaag gcacttggaa actaaaattc agtaatgatg 3810361 ttattgtgaa aatcaaataa cagctaacaa gggtgcctgt ttaggcaccc ttgttcttta 3810421 aaaaaggcct tctcaattga gaaggcctcc attcttattc cgcactctta tacccattca 3810481 cattagaaga ctgccatctc caggaatcag cacacatttc ctcaaggccg cgtttcgctt 3810541 cccagcctag ttctcgcttg gctttcgcag gatctgcaaa gcatgtggcg atgtctcccg 3810601 gacggcggtc cgcaaaacgg tatggaacct ctttccctga cactttttca aaggctttga 3810661 ccatttccag cacgctgtag cctgtgcctg ttccaaggtt gtatgcatcg gctcctgtag 3810721 agttcaatac tttttccagc gccttgacgt ggccttctgc gagatcaacg acgtgaatat 3810781 aatcgcgtac gcctgtcccg tcttttgtcg gatagtcatt tccgaatacg cttaattgct 3810841 cgagcttccc gactgctacc tgtgccacat acggcataag gttatttggg attccgttcg 3810901 ggtcttcacc gatccgtccg cttggatgcg cgccgaacgg gttaaagtaa cgaagcagcg 3810961 caacgctcca ctcattgtcg gctgtatgca aatcacgcaa tatttgttca agcatgagct 3811021 tcgtctgccc ataaggattt gtcgcgccta atggaaagtc ttccgtaatc ggcgatgttt 3811081 ccggaacgcc gtatactgtc gcagatgaac tgaatacgat tttcttgacg ccgtatttct 3811141 ccatggcctc gcataaaata aacgttcctg tcaaattgtt atgataatat ttgaggggaa 3811201 tcgccacaga ttcgccgact gcttttaacc ctgcaaaatg aatcacagct tcgatttcat 3811261 tttcagcaaa aacggaatct accgcttccc ggtccaataa atccgcttcg tagaacgtta 3811321 aatcttttcc tgtaatctcc ttgacacggt tcagcgcttc agctgaactg ttggacagat 3811381 tatcaagaac aacaatctcg tagccgctgt tcaatagttc aacacatgtg tggctgccaa 3811441 tgtaaccggc accgccagta acaagtattg ccatgatgta aaccctccta aaaaatgacc 3811501 tgttttcatt atatagtgtt tagaaccggt ccacatccat ttttaagaag tttaatcgtt 3811561 tattaatagt tttttcatat tttttagctt aaacccttgc cagcaattcg atagaggttt 3811621 cagcaagaat gtgctctttc atttcttgat agagctcatt caagtaaaag cccggctgaa 3811681 gattcagctc agcatctaaa gcatagaccg tcaatgtata cgcatgatcc ttgtcaggcg 3811741 gtgtcggccc gcaatactgg tgaatcacct ttggatcgtt gcttcccgca agcggtgaag 3811801 caaagctgtt ttgcccttgt atcatcaagt cctgtctttc ctcactcgca tgttcaggaa 3811861 gctctccgat gtaagccgga atattagccg ctgtccagtg aatccagctg aatccgcata 3811921 cgggaatggc gtcatgatcg atgaaagtaa gtgcgagcgt ctttgctccg gacgggatgt 3811981 catcaaaatg aattggaaag gatacaaatg ggtttccttc tctcttatat ttttcatccg 3812041 cgtattttga atacttgtca tgtaaatatg gatttgcttc tacgtatatg ttcatatgaa 3812101 tccctctctc tattttctcg ttctataggt atactaaacg aatcgatgta taatcagtga 3812161 taaacaaata cgcatgtaaa cgtaacaatt tgttatggat aacttgcagt gaaggagata 3812221 tttcatggat ttaaaatggc tgcaaacctt tattgccgca gcggaatcag agagcttcag 3812281 ggaggcggct gagcatctgt atctcacaca gcctgccgtt tctcagcata tgaggaaatt 3812341 ggaagatgaa ctggacatga ggttgttttt gcatagcgga agacgagtcg tactgactga 3812401 cgaaggcagg ctctttttgc cttatgccaa agaaatgatc catgtttacc aagctggaaa 3812461 gcagaaagtc agtcaatgga aacaggggta cagccgatca ctcacgctgg ccgtacaccc 3812521 ctacattgcg tcctatatct tgcctcgctt tctgccagcc tatatccaaa aacatccgca 3812581 tgtcgagctt tcaactcatg tggctggatc tgacgctatt aaacaagcgg tggaacacaa 3812641 tgaagctgat attggtttgt cgcggaaaga cccgaacacc aacactcttt attatcagca 3812701 tatatgcgaa ggtacgcttt gtctggcggc tcctttccaa gaaagcagac cggatgctgc 3812761 atccgtctta acccgctatc ggctgctaac gcatgatcat ccgtcatatg gggatgcctt 3812821 tttagataac atccgatcac attacccgta tcttcaaatg atggctgtcg ggcagacgga 3812881 tacggctgtc cacatgatga aagcgggaat gggggcatct ttcctcccta cctacattat 3812941 caaacaggaa gaagccgaaa aaaagctgat ggctgtcagc acgcctgcac atctagaatt 3813001 gcctgcgtcc caaacgttta tgatgtggaa aagaaacagc gaagacattc agcattttca 3813061 cgccatgtta catgacttta tgcagcgcga acaagtatag agctgaaaaa tcaatctgcc 3813121 ggttgacgtt tttctttcct attttcgcta tgcttaatgc agaaaggatt tgatgacatg 3813181 gcgatgagcc cttatatttt tattgtattg attcttatta ttttatcgat gtatcgagaa 3813241 agaacggtaa agcccgggaa gttgctgatc attccactgt tgctcttatg gggcgtatct 3813301 gcatcgtttc agccggcgta ttttcattcc gtattacatg tggcgatcag cggcatttta 3813361 ttactgatcg ggctggcctg cgggtttggc attgggaaga tggtaaatgt acggattcac 3813421 ccggaaaccg gaaaggtcac ttcacgcggc tcacttggga gtgttatcct cattctagtg 3813481 atactttctt tgcgcatggc cgcgagaaca tggctgcctg agagcaacga gatgtttatt 3813541 gccattattc attctatgtt cttcgttccc ctcggcacca tcacagcccg caacatcatg 3813601 ctttacaaag catacagacg actgaccgct ggcaaagtat ccattcaata accgaaagaa 3813661 ggaccagcat gaacggacaa actccggctc ggcactacta caagaagctt gtgccgagcc 3813721 ttattctcat tttgaattgc atacaatttt tatctcatcc aactaaggct gatcccattt 3813781 tgttagcatt tgtatttgcg gtatacttag cattcatttg gatcattccc tatgtggcat 3813841 ccactgctgt tagtttgagc atattcatcg gactctggct cctgaccgat ttcttttggg 3813901 ctgtttccgg ccaagagcag ggtgccgcct attttttgat tgtattttta atgatatatg 3813961 ccgcctttag actcccttca cggctatcct tgatcttcac agcatgttta attggaggca 3814021 acatattact cctatcctca caagggggaa gcttgaatac catcatcagc aacatctcga 3814081 tcatgctcgg tctgtacgtc ctcttctcct ccatgcgttt cagacgagaa gcgagaaggg 3814141 aggctgaacg gaatcatgct gaattggcaa aaatgcatgt gcagctggag catgctcata 3814201 aagaactcca gaaagcgcat gcagagctgc aggaggcttc tgttctttca ttaaggtacg 3814261 cggtccttga ggaacgtaca agaattgccc gcgacattca tgacagcatc ggtcacgagc 3814321 tgacttctgt gattgttcag cttcaatccc ttccctatat ccttaaaagc agcaaggagg 3814381 attcagaaaa agtcattcaa aatgtactga gtgtcgccag ggagtgtctt caagaagtgc 3814441 ggtctgttgt tcaccaaatg ggccgtagtg aatcgatggt ggggcttacc gctttgcggg 3814501 ggctcattca tcaagtggag gaacggagcg gcttgcacgt ttctttagat actgccggac 3814561 tgtcagaaga gtcttggcct ccaaacgtga gcgaaacgat ctaccgcatc ttgcaggaag 3814621 cgctgaccaa tatcattcgt cacgctgacg cttctcatgc ggcggccgtc atttctaatg 3814681 acaagtccca tctctatgtc acaatcaccg acgacggaca attcaccggc agccttactt 3814741 atggatttgg cctgacagga atgaaagagc gcgcagaaaa agcaggcggt tcccttactt 3814801 tcagtgccgt acagccgagc ggcctgaaaa ttgagctgtc attgccgctc atgacaacga 3814861 ataaggagca aaaagatgaa caaagataaa atacgcgtag cgcttgccga tgatcagccg 3814921 cttgtgcgtg aaggcttccg ctacgtcatc aacgcacaga cggatatgac ggtttctggc 3814981 gaggccggcg acggtcacga tattatagca ctcgcaaaac aaacaaaacc cgatgtcatc 3815041 ctcatggatg tccagatgcc gcgttgctca ggcatcgaag cggcgaaaga cattatgtcc 3815101 gcacttccaa atacaaagat agtcatttta accacctttg acacggaaga atacgtattt 3815161 gaaggcatcc gtgcgggcgc agtcggctat ctgctgaagg atacacttcc tgaggagttg 3815221 atagatgcga ttcgcgctgc ggccagaggc gaggcgattt tccgtacagt cacagctgct 3815281 aaaatcatca gtgagacatt tcgggcgaaa cagcaaactc atgccgaaga actggcagag 3815341 ccgttcacca aaagagagct tgaggttctt cagcaaatgg cctacggact gagaaatgag 3815401 gatattgctg aaaagctttt cgtcagtgaa agcactgtga aaacccacgt gcaccgcatc 3815461 ctgcaaaaat gcaatgccca agaccggaca caggcagtcg tttttgccat tcgaaacggt 3815521 attgtgcaat agaaatctct catcccgcca tgctaaaata agacaaagga gatgattgga 3815581 aatgaaagaa gaaatcattg aacggtttac tacatatgta aaagtcgata cacagtccga 3815641 tgaatccgtt gacacttgtc cttccacacc cggccaattg acattaggaa acatgctagt 3815701 tgatgaattg aagtccatcg gcatgcagga tgcagccatt gatgaaaacg gctatgtcat 3815761 ggcaactctt ccctccaata ctgaaaaaga cgtgccgaca atcggctttc tcgctcacgt 3815821 cgacaccgct acagacttta ccggcaaaaa tgtgaatccg caaatcatcg aaagctatga 3815881 tggaaaagac atcgttctta acgaacagct gcaggtcacc ctgtcacctg atcaattccc 3815941 tgagctgtcc ggctataagg gccatacact catcaccaca gacggcacca cccttctcgg 3816001 cgcagacaat aaggccggta tcgctgaaat catgacagcc atggattacc tcatcaaaca 3816061 ccctgaaatc aagcacggca caatcagagt cgcctttacg cctgatgaag aaatcggaag 3816121 agggccgcac aaatttgatg tgaaacggtt caatgcatcc tttgcctaca cggttgacgg 3816181 cgggccgctc ggcgagcttg aatatgaaag cttcaatgcc gctgccgcaa aaattacgat 3816241 taaaggcaac aacgtacatc ccggaacagc taaaggaaaa atgatcaact ctgcgaaaat 3816301 cgcgatgaag ctgaacagcc tgctgccggc agacgaagcg cctgaatata cggaaggtta 3816361 tgaaggcttc taccacctgc tgtcgattca aggagacgta gaggaaacaa agctccacta 3816421 cattatcaga gactttgaca aagagaattt ccaaaacaga aaagaaacaa tgaagcgtgc 3816481 cgttgaagaa cttcaaaacg aatacgggca agaccggatt ctgctggata tgaacgacca 3816541 atactacaac atgagagaga aaattgaacc tgtcatcgaa atcgtcaaca ttgccaagca 3816601 agcgatggaa aacctcggca tcgaaccgaa gatttccccc atccgcggcg gaaccgacgg 3816661 atcacagctg tcctacatgg ggcttccgac gccaaacatc tttacaggcg gggaaaactt 3816721 ccacggcaaa tttgaataca tctcagttga caacatggtc aaagccgtaa atgtcatcgt 3816781 tgagattgca aagcagtttg aagcgcaagc ataacgccaa aagccagtcc aaaaaaggac 3816841 tggctttttt gtgtgaaaat gaaacatttt aaacacgtcc tccgtaaaac aagtatcaac 3816901 aaatgaggag gaaaaacaat gacaaaacat gcaatcgctg ccaagagtct cttgaaaaaa 3816961 tggatcattt ccaggccgct taacatgaaa aagaaatcca gcccatttca aaaaatcaga 3817021 aaaatgttca aacgcttctt caaataaaac atcaaatccc ctaaatacaa tccgtattca 3817081 cccgtaccgc ccaaatgctc cgtaatttgg gttttttgtg ttcaattccg caaaataggg 3817141 tataaaccaa acaagcaaga aaacagcacc caaaaacagg taattcgaat tacgtaaact 3817201 taggttaaaa gttatataaa ggaatttatt ttatcgtcga tagtaactat agaaccaatc 3817261 atcaacaaga gcaaacagcg taattcaaga ctattttcag gtcatcaggt aatactgttt 3817321 tagagggaca gtttcttgtt atttattgat ttagaatttt ttgaatactt tttggcattt 3817381 tatccgtaca atagagagta ccaaaacttt ttttgggagg tatgtaatat gatcctattt 3817441 attatcatcg cattatgcgg ctatcttctt ttttctttca gcaaggacaa tcgccgcaaa 3817501 ccgcaaaaga caagccctct gccagcagcc gcacctcatc acaacaacct aatcgacctt 3817561 gacgccatcc gccaaaaacg ccggatgcat ctttcctaat tctatatttc aaacgaaaag 3817621 gctgctgaat cacgcagcct tttaaaattg ttttgattta gagcctgaaa ccttttcgcc 3817681 acctatccgt aatttcatac aaggcaaacc caaaggagac ttcagcaatg atcgagttat 3817741 ttatgaaaca aaaaatgttc tcatttaaag atgcatttca catttatgac cgggatgaac 3817801 aagaaacatt caaggtggag gggcgttttt tctcgttagg agactcatta caaatgacag 3817861 actcatctgg gaaaacgctc gtttccatag aacaaaaact aatgtcttta ttgccgcgct 3817921 atgagatttc aattggcggg aaaacagttt gtgaggtaac gaagaaagta acgttttcca 3817981 aaccgaaatt tgtgatttcc gggcttaact gggaaataga tggtgattta tggagggatg 3818041 aattccaact gacggacggg gaaaatgtcc ggatgtcagt gagcaaaaag tggctcagtt 3818101 ggggtgattc ctatcacttg cagattgcat acgaggaaga tgttctgatt tgcactgcca 3818161 tcgctatcgt gcttgatatg gttttatata acgatgaaga tgaaagtatt ttctaaaaag 3818221 cattgacaat tgatccaaaa gtaataatat taagataatt gaaatctgaa tatgaagttg 3818281 taccttatca agagaggtgg agggactggc cctatgatac ccggcaaccg ctgtttcaaa 3818341 cagaatggtg ctaaatcctt aagaacattg cgttcttgca gatgaggcgg agatttgatc 3818401 gttcaagctc ttccttacac aaaggaagag ctttttacat gcttaatatt tcagaaaaga 3818461 ggcgaataac atggctcaac aaacgaatgt tgcaggacaa aaaacagaaa aacaacgcaa 3818521 agcacctttc cgcgccgatc atgtcggcag cttgcttcgt tccgttccgg taaaggaagc 3818581 ccggcaaaaa aaagcggctg gtgagatgac agcggaacag cttcgtgata tcgaaaatca 3818641 agagatcacc cgcatcgtgg aaaaacaaaa agaaatcggt ctcgatgtgg taacagacgg 3818701 ggaattccgg cgttcctggt ggcattatga cttcctggaa gggcttgacg gtgtggaacc 3818761 gttcatcccg gctgagggga ttcagttcca taacacaaaa acgaaagcgc gcagcatcaa 3818821 agtgacggga aaactcgatt ttacgagcca cccagcgctc ggtgattatc aatttttaca 3818881 tgagattgcc ggtaacgcga cgccaaaatt gaccattccc agtccaaata tgctgttttt 3818941 tggcgaaaag gcggataaag ggatttatga cgatcaagag gaatactttc atgatatggc 3819001 ccaagcgtac aaaaaagcaa tcaaagcctt ctatgatgct ggctgccgtt atctccagct 3819061 tgatgatacg tcatggtctc tcttctttga ggacaaaggc agagaggttg tccgggcgct 3819121 cggcggtgat ccagaaacat tgccagccat atttgccaaa acaattaacg atgccgtcgc 3819181 agaccggcct gacgatttaa cgatcacaat gcacatttgc cgcggcaact tccgctcaac 3819241 ctgggcggca tcaggagggt acgacgctgt agcggaaacg attttggacg gcttaaacct 3819301 tgacggcctt ttcttggaat acgatgatga ccgctccgga aactttgatc cgctccgttt 3819361 tgtgaagcgc aaggatctgc aaattgtgct cggcttgatc acatcgaaat acggcgagct 3819421 tgaaaatcct gaggatgtga aacgccgtat caatgaagcc gcgcgttttg tcagcttgga 3819481 ccagctatgc ctgagcccgc agtgcggttt cgcctctaca gaagaaggca accttctgac 3819541 agaggagcag caatgggcaa agctgcgcca tgtcatcgac attgccaacg atgtgtggag 3819601 ataatctatc attgacagaa atagaaaatg tgtgaataat agatactatc agaaaattta 3819661 ataaaaaggt tttccttatc aagagaggtg gagggactgg ccctgcgata cccggcaacc 3819721 gctgtttaac agaatggtgc taaatccttt agagcaatga ttgctcttga agataaggtt 3819781 gagattgtca cgcaagctct tccttatcca aaggaagagc ttttttatat ttgaatggaa 3819841 agaaggaatg gacaacatgt cacaacaaac aacacccgca gaacaaaaat cacttcaaag 3819901 aaaaaaaccg ccgtttcgcg cggatcaagt cggaagcctg ctaagatctg agcccgtcaa 3819961 aaaagcgcgg ctgcaaaaag cggccggcga aatgaccgct gagcagcttc gccaaattga 3820021 aaacgacgaa atcatccgca ttgtggaaaa acagaaggaa accggcctga acgtcgtgac 3820081 agacggtgaa ttccgcagag catggtggca ctttgatttc ctggaaaact tagatggcgt 3820141 tgagccgttt actcctgagc aaggcattca attccataac gtacagacaa aagcacgcgg 3820201 cattaaagtc acaggcgata tcgacttttc aactcaccca atgcttgaag attactcatt 3820261 tctccatagc attgccggtg acgcgacgcc aaagatgacg attccaagtc cgaatatgct 3820321 gtttttccgc ggaaaactgg aaaaggatga atacaaaaac gattatcaac ttttccagca 3820381 cgatgtatcc aaagcatata aaaaagcgat tcaagcgttt tatgacagag gctgccgcta 3820441 cctccagctt gatgatacag cgtgggccgt tttcttatca gaaaaaggct taaaacaaat 3820501 cgaagcgttc ggaacaacgc ctgacgagct tcgccagctg tttgcgaaat ccattaacga 3820561 cgcgattgca gaccgcccgg atgacttgac ggtaaccatg catatttgcc gcggcaactt 3820621 ccagtccact tggacagcgg aaggcggcta tgacgcagca gccgaaacca tttttgacgg 3820681 cttgaatctt gacggacttt tcttagagta tgatgattca cgctcaggcg gatttgagcc 3820741 gctccgttac gtaaaacggt ctgatcttca gcttgttctt ggcttagtga catctaaatt 3820801 cggtgagctt gaaaatccgg atgacgtgaa acgccgtatc gaagaagcgt cccgttatgt 3820861 aagcttagac cagctttgcc tcagccctca atgcggattc gcttcaactg aggaaggcaa 3820921 caagctgact gaagaacagc aatgggcgaa gctccgccat gtggttgaga tcgctaatga 3820981 tgtttggaaa taagcaaaga aaaaaacaca cttgattccc tagcggagca agtgtgtttt 3821041 ttatgtcatt gtgcggtgta gcccccatca aggacgacag cctgcccagt gacgcccttc 3821101 gccttctcgc ttgccaaaaa cacggcataa tccgcaattt ccttgacgga aagcagtcgc 3821161 ttttgcggca caagcggaaa aatgacttgt tcaagtacag agtcgtaagg gacatttcta 3821221 gttttcgata gatcgctaag ctgattgcgt acaagctggg tatcgacata acccggacag 3821281 agcgcattga ctgttatgcc gtggggcgcg ccttccagcg cccctacttt tgtgagtcca 3821341 atgacgccgt gcttggcgct attataagcg gatttccctg caaagcccac taatccatta 3821401 acagacgcaa tattaatgat tctgccaaac tgctgttttt tcatgatcgg aaaaacatgc 3821461 ttcattgcaa taaagggagc cgtcagcatg accttgatca gctgttcaaa ggtgtctgtc 3821521 ggaaactctt caatcggagc gacgtgctga ataccggcat tgttcaccag aatatccaag 3821581 cggccgtatt gtttttggat gacgttcacc gtatcagcaa cttgcgcttc ctttgtcaca 3821641 tcatacggaa tggccgccgc gtcaaagcct tcttctgcaa gcttggaggc tgctttttca 3821701 catgcttccg gacggaggtc tgaaacgatg acgctggcac cttcccgggc gaattctctt 3821761 gcgatttcga atccgattcc gccggcagcc cctgtcacca aagcgacttg ttttctcatg 3821821 tcaaacacct tcccattaag aattgagtac agactggctt acagcgaaat cagcttctgt 3821881 tttttcataa acctcttcaa ttgtgacacc atcctgaagc tccgtcagtg tcatgcggcc 3821941 gttcacaaaa tcaaatacag ccaaatccgt aatcagcctg tgtacgactt tctggcctgt 3822001 cagcggaagg gagcatgttt ttttcacctt tgattcacca tgcttattga cgtgctccat 3822061 gatgacaacg attcgtttcg ccccgttgac gagatccatg gcgccgccca tcccttttac 3822121 cattttgccc gggatcatcc aattggccaa atccccctgc tccgaaacct ccattccgcc 3822181 gagaatagct aaatcgatat gcccgcctct tatcatcgcg aatgactcag cgctgtcaaa 3822241 ataagaggcg cctgtcactt cagtgatcgt ttcctttccc gcattgatca aatccgcgtc 3822301 ttccgttcct tccagaggat aggggccaat tccgagcaag ccgttttccg actgaagcat 3822361 gacgtgaacg ccatcgggta tctcatttgc gacaagcgtc ggcattccaa tcccgagatt 3822421 cacattcatg ccgtccttga tttcttgtac agcccgtttg accattcgtt ttctcgcttc 3822481 cttcacttgg cctcaccctt tcccgatgct tgctgaactg ttcgtttttc aatccgtttt 3822541 tcttggctcg cgccaagcac gacatgctgt acgtaaattc ccggcgtatg gatgtgatct 3822601 ggatcgagct ctcctgcttc cacgatttct tccgcctcgg caatcgtgat cttgcctgcc 3822661 atggcggcaa tgggattgaa atttctcgcc gttttcctaa aaatcaaatt gcccatggtg 3822721 tccgctttcc acgctttgac gatcgccaca tcgccggtaa tgcctcgctc cagcacataa 3822781 gtccggccgc cgaatgtttt atgttctttt ccctcggcta tggaggtgcc gacgcctgtc 3822841 gccgtataaa atcccggtat gcctgcaccg cctgcacgaa ttctctcagc gagcgttcct 3822901 tggggaacaa gctctacctc aagctctccg cttaaaaact gccgctcaaa aattttattt 3822961 tcaccgacat aggaagcgat cattttcttg atttgcttgt tagccagaag caaaccaagc 3823021 ccccagtcat cgactccgca gttattgctg acaacggtta aatcctttac tccctgatct 3823081 cttatagaca aaatgagctg ttcagggatg ccgcacagcc caaaccctcc cgcgatcagc 3823141 gtatccccat catgaatcag tttcgcagct tccttgcttg atgacagcac ttttcccata 3823201 ttgatgcccc tttcgttttc ttctacacta gaccagtcag gctgtaaatc gcgatcacag 3823261 caaatacggc agccgtttta atgagcgtga tcgcaaaaat atcgcgatag gattgccggt 3823321 gggtcaaacc cgtcacggcc agaagcgtga taacggcgcc attatgcggc agtgtatcca 3823381 tcccgcctga tgccattgaa atgacccgat gcatcacctc tggcggaata ttgtaagcct 3823441 gaatcgcctg taagtattgt tctgacatcg cgcttaacgc aatgcccatt cctcccgaag 3823501 ccgagccggt gattcccgcc agcgcagttg tcgtaacggc gccatttaca agcggatcgg 3823561 taaaagtatg tgaaattccg ctgctcagct tatgaaaccc cggcagcgcg gcgataatgc 3823621 cgccgaaccc gtactcagca cccgtattca tagatgccag caaggcgccg ccaattcctt 3823681 cattcagccc ttccttcaat tgggcaaaca cacttctcca atcaaataat atcgttgtga 3823741 tgatgccaat cactaaagca atctccaccg accaaatagc agccgctgaa gaaatatcaa 3823801 gcctgccgaa ctcctttaat cctatggaag aaaaatcaaa tccattcgga taccactttg 3823861 gcaggtaaat ggtgaaatat ttattcactg caccgacgag aataagcggg acaaaggcaa 3823921 gcgcgtgccg aatcgggctt ttgtccggtt cagccgcgga ctcaatcgat tcaggagcag 3823981 gagcattctg cgaatcaaaa ccgccatagc cttcgccaga tgcctgcgct ttcttccgcc 3824041 ttgattccaa atagagcatc ccagctgcca gcacaatcac tgcgcccatc aaacccagcc 3824101 aaggggcggc ataaatgtct gttttgaaaa acgacgtcgg gatgacattt tggatttgcg 3824161 gcgttcccgg aagtgcgtcc atcgtaaacg taaaagctcc taaagcaatc gtacccggga 3824221 tgaggcgttt tggtatgttt gcttcttgga acatgttttt cgcaaaagga tatacagcaa 3824281 atacgacaac aaacaggctg acaccgctgt acgtcaagac agcacccatc agcacaatgg 3824341 caagtatcgc tctttttgcc ccgacaagcc ggacaattgt tttcgcgatt gatgccgcaa 3824401 gcccggccat ttcaacgacc tttccaaaaa tagcaccgag caaaaacact gggaaataca 3824461 gcttaataaa acccgccatc ttctccataa aaattgatga aaaaaaagga agcacatggc 3824521 ttggatctgt cagcagcacc gcgaataacg cgcaaatcgg cgcaaacaat atgacagaaa 3824581 atccccgata cgccgtaaac atcagcaaac ctaacgccaa tagaatgatg atcagttcca 3824641 cacacacatc ccccgtttcc gcgaactaga aagcgtttac aaaaacctgt ccgcatcggc 3824701 tgtttccgtc ccctttccat atgtacgaga agcgtgggcc aactattccg attaaaaaag 3824761 gaaagctcct tttttcggag ctttcctcta ccattcattt cattcctatt aggatatcaa 3824821 catcaaccgt aatatcggct gatttcatct ctttcagcag gctgactcga tctttcggcg 3824881 ccgaccaggc aagcggcgtc atcttgagaa gccagtggat cgcctgctgg tcaagcgttt 3824941 taacatagcg cagcctgaca ggacggctgt gtgctgcatt tgctgtaaaa cgctcaactg 3825001 ctgccgtatt ggaatacgtg cgccttggtg aatcagtata taaaaattgc cttaattcta 3825061 ttaaatagtc gcttcgcggc actactttta tgagcatgcc atcattcttc agcagtctat 3825121 gaaactctgc ataattggac ggcgaaaaaa tagacagaac aacatcaaat tggcgatcat 3825181 gaaaaggagc acgcgccaca tcggcaaccg cccacatcag atctttgaat gccttagaag 3825241 cttttaagat cccgtccttc gaaagatcta tgccggttcc tatcgctgct ttccctgcat 3825301 aatcaaaccc gcaaagcgca ttcaaatgag aaccctcacc gcaaccgctg tccaagatgg 3825361 tgaatgcctc atgaccagat ttgggatgac tgatgagctc tgcaatcgca tcatggagcg 3825421 ggtcaaaaaa accacattct ccaatcagcc tgctcctcgc ttcaaaaagc tcggcaccgt 3825481 aactggtttt gaccggcttc gtcagaaagt tcacgtagcc gtgccgagat agatcaaatg 3825541 tatgtcctcg ttctgtacaa atcaagcttt tccctgatgc cgcatccata gaagaatcgc 3825601 agagcgggca tcgaaacatg ctgaaatcaa ctgttcgctt catgataaaa aacaccccat 3825661 tcattcattt ttagataaat gaaaaaggca tagacaaata aacctaggcc tatctcaaaa 3825721 attggccagg tctggcagtt tgtctacacc tgtcattatc tataacgaat gaattggata 3825781 atcatgaaaa aaactccctt tctgctgtat gggtttcccc gtttccatca tacaacaaat 3825841 atccaggagc tggaacctta tagtgaagaa aaatcagtac tgacatgctg gtatcccgcc 3825901 aacatcatat cagcatagca atccagcatg tttttccttt attttctcat tttagaatat 3825961 aaattttatt attgtgaaaa tagttaaaaa ggttgatttt caaaaagtga aaggataaaa 3826021 tactgctatc atcttagaaa aagacattct tgtatatgat cagtaatatg gtctgattgt 3826081 ttctacctag taaccgtaaa aaactagact acaagaaagt ttgaataaat ttgaacgagt 3826141 tgaaaaggac aagttctttt ctgtttgctc ttatttttca cactttctgc acttccagaa 3826201 tttgtgaagg ataagagctt tttttgtttc cataataacc ctcataggag ttgctatcat 3826261 gtacttttta ctaaaccttg tcggtctcat tgtgattatg gcagttgtat tcctatgttc 3826321 tccgcagaaa aagaaaatca agtggcgccc gatcattacg ttaattgttc tggaattgct 3826381 gattacttgg tttatgctgg gaacaaaagt cggaagctgg gccatcggta aaatcggtga 3826441 tttcttcact tggctgattg cttgcgccag tgacggtatc gcgtttgcct ttccgtcagt 3826501 gatggcgaat gaaacagtag actttttctt tagtgcgctt cttccaatta tctttatcgt 3826561 cacattcttt gatattttaa cgtatttcgg cattttgcct tggctgattg ataaaatcgg 3826621 atgggtgatt tcaaaggctt cccgcttgcc gaaattagaa agctttttct ctattcaaat 3826681 gatgttcctt ggaaataccg aagcacttgc ggtcatccgc cagcagctta cggttttaag 3826741 caacaaccgc ctgctcacat tcggtttaat gagcatgagc agcatcagcg gctccattat 3826801 cggatcttat ctttcaatgg tgcctgcgac atacgtgttt acagccattc ctttgaactg 3826861 cttaaacgcg ctgattatcg caaacctgct gaatcctgtt cacgtgccgg aggatgaaga 3826921 tatcatctat acaccgccta aagaagagaa gaaagacttt ttctctacga tttctaacag 3826981 tatgcttgtc ggcatgaaca tggttatcgt tattttggca atggtgatcg gatatgtcgc 3827041 attaacgtca gcagttaatg gcattcttgg cgttttcgta catggcctga ccatccagac 3827101 aatttttgct tatctgttca gtccgttcgc attcctgctt ggactgccag tgcacgatgc 3827161 gatgtatgtt gctcagctga tgggcatgaa attagcaacg aacgagtttg ttgcgatgct 3827221 tgacttgaaa aacaatctca aatcccttcc gcctcacacc gttgcggtgg cgacgacatt 3827281 cctgacgtcc tttgcaaact tcagtactgt cggcatgatt tacggcacgt acaattcgat 3827341 ccttgacgga gaaaagtcaa cggtcatcgg gagaaacgtg tggaaactgc tcgtcagcgg 3827401 aattgcggta tctttattaa gtgctgcgat tgtcggcctg tttgtgtggt agaaacattg 3827461 agccatatcc cttttcggat atggctcttt tcattattga taaatagagg ctggcacctg 3827521 cacatcccgg attcccgctg cataaggccc caagtcatac tggccgaaga cgatggcgat 3827581 cccgtttgcc gtaaagtaaa acattgtgtc tctgtttagg gttatatcct ctttctttac 3827641 atcagagaaa aacagcacat cgtgtttttt gatatagcta tataggtaat ctctcgtttt 3827701 gctgactttt gttttggtgt tcagaatctg atccagcgtc acccgctttt gtgctttcaa 3827761 gtcatagttg aaggactgga cagacgttag accgtgggcg ccccctgaat agatataatt 3827821 gagtgtttga atgctgagct tgcctgccgc attgtatttg acgctgaagg atgtttgata 3827881 ttcccgtttt aaagccctgc tgttcgcctg cttttttgtt tttcaggtat tcctgatacg 3827941 attgttcatg taggctttca gctcttgatt gattttcttt tcaaacgcgg cattcccgac 3828001 gtgatgcact tgtggatacg ttaactcctt gatctttttg tacgtatggg tgctgacagt 3828061 cggtgttttc gcttgaactg cttttaaaga tggggccgca tatgcaaata cagaaaaaag 3828121 caagactgca atgcccgcgg ctttcagcat gttattccat ttcatacaat ctactccttt 3828181 gatgtcgttg tttatcattc ccttatttaa gcaatacaca cttttataga ctgattaaat 3828241 cgaaagaagt ttctaggtct aacagcatga tttttccaat aaaaaaagag acacaggatg 3828301 tctctttttt tactgtttgc gcccagaaat cgcttcatga agggcttgtg ccaaatctgt 3828361 atttccgaac atctctaata ccgcaatgac agtctggtcc ggaatgtgct ctgcttcgtg 3828421 ttttggcacg accagatcgt ccatggtttt tttcaagctt tcattcagct tttgctgcgg 3828481 atacgctttg gcgtacagct ccatcggatc aagatcatgg ttcacgcacc actgggcaaa 3828541 caccaaaatc atcatatttt catcgcgttc gtaagcttca gtgagctgtt tttcgttcat 3828601 ttgtcatgct ccttatgaaa agtatcttcc ttaaagatac aggagccgat caaattcgtc 3828661 tatcccaatg gcgatgagca gcaaccgcat cgataaatgc cttgctgaaa gcggtgtagt 3828721 caggttcatc tttagccgtt acgatgccta gcccctctgt tgtcccgaca gaggattgaa 3828781 gaaggtcaat tccttcattt gccgcaccga tcgccttgta gtgattgtaa gcttctctga 3828841 taaacgccat cgcttgtttg ttgtctttta actccagtcc tcctgcggca tagacggcat 3828901 catacagaac agaatcaacc gtcaggaacg tgccgctggc ctcaagctgc tgtccgctgc 3828961 cgcttgtcat ataccccaga ttttgactga tgatatccac tgtgattcct tcttgcttta 3829021 aggcttccag tactgtttgc agctcttttt catgaaatcc gtttccggcg agtacagcga 3829081 cttttcttgt tgacgcggtt ttcactgtac gggcttggct taacgcaggc gaagtaagaa 3829141 tttctttaga tgctttacgc ttcgcgggcg ccgccacgcc tactcctttg gcgatttctt 3829201 ctgctaaatc tgcatcgaca ttgctgaaga catcaacgac ctgccgctgt acgtctttgc 3829261 ttttgacctt cccgacctcg aagcagaaag cagaaatgat gtgctgtttc tccacaggag 3829321 acatgctgtt ccagaaaagc ttcgcctgtg agtaataatc gttgaagctg tcgcttcgct 3829381 ggcggatttt tttgccctcg actttttcct gatagtggac gtagccgcct tcttcagctg 3829441 tcgcaggcga cggatcattg ttttgcagtg agtttttatg ataagcgaca ggtcccttat 3829501 tgatcgtcat ccggtgatag ccgtcgtatt ggttgttatg gaatggacag accggccggt 3829561 taatcggaat ctcatggaag ttcgggccgc caagacggat gagctgtgta tccgtataag 3829621 agaaaagccg cccctgcaat agcgggtcat tggtaaaatc gatgcccggc acgacatttc 3829681 ccgggtggaa tgcgacttgt tctgtttccg caaacacatt atcctgattg cggttcagcg 3829741 tcatttttcc aatgatcttc accggcacaa gctcttccgg ccacagctta gttgggtcaa 3829801 gaatatcaaa atcaaacttg aattcatctt cctcatcaat catctgcacg ccgagctcgt 3829861 attcaacctt gccgccgttt tcaattgttt cccacaggtc acggcggtgg aaatctggat 3829921 ctttcccggc aattttttgc gcttcatccc atacgagaga atgcacgccg agcaccggct 3829981 tccagtgaaa tttcacgaaa cgtgcctttc cttgttcatt gacaaaacgg aacgtgtgaa 3830041 cgccgaagcc ttccatcatt ctgtagctgc gcgggatgcc tctgtcagac atcgtccaca 3830101 tcaccatgtg ggcagactca gggttattgg cgacaaaatc ccaaaatgta tcgtgagcag 3830161 tcgcagcctg aggcatttca ttgtgtggct caggcttaaa cgcgtgaacc aaatccggaa 3830221 atttgattgc gtcctgaatg aaaaacaccg gaatgttatt tcccacaagg tcatagtttc 3830281 cttcttcagt ataaaatttt gtcgcaaagc ctctggcatc ccgcaccgtg tctgcggagc 3830341 ctttagaacc cgcaaccgta gaaaaacgga caaataccgg tgtcttcacc gaagggtcct 3830401 gaagaaattt ggcccgtgtg tattccgtca ttggttcgta aacctgaaaa aagccatgca 3830461 cgccaaatcc gcgcgcatgc acaacgcgct ccggaatcct ctcatggtca aagtgcgtca 3830521 ttttctcccg gaaatgaaaa tcctccatca gcgtcgggcc gcgaaccccg gcttttaacg 3830581 agtgctcatc ctctgacact cgcaagcctt ggtttgtcgt cattttcttc ccgctgttat 3830641 cggtcctgta ctgctcaagc tgctcgtcct ttgagtgttc atttacacgt ttgttttggt 3830701 catcactcat gtctgctccc cctttttaaa acgaaacatt ctacagcaca tttacccgtg 3830761 gcgttcttca tataaactgc taatccgctc attaggattt ttggtctaca tataaatatg 3830821 cggtcataca catttgaaat aagccttctt cacagaaaga aaggatggaa gcgcttacca 3830881 aaaaagctgt tgaatagggg aggtcatatc atgcttgcca tactcggttt tgtgatgatg 3830941 attgtcttta tgtaccttat tatgtctaac cggctttccg ctcttattgc tttgattgtc 3831001 gttcctattg tgtttgccct gatcagcgga tttggcaaag atctcggcga gatgatgatt 3831061 cagggcgtta cagacctcgc ccctaccggt atcatgctgt tattcgccat cctgtatttc 3831121 ggcattatga ttgactcagg cctgtttgat cctctcattg ccaaaatctt atcgtttgtc 3831181 aaaggagatc cgttaaaaat cgccgtaggc acagcggttc tgaccatgac catttcgctg 3831241 gacggagatg ggacaacaac ctatatgatt accattgcag cgatgctgcc tctctacaaa 3831301 cggctcggca tgaaccgttt ggtgttagcg ggaatagcga tgcttggttc gggggttatg 3831361 aatattatcc cgtggggcgg gccgactgcg agggttttgg cttccttaaa attggacacg 3831421 tcagaggtct ttacaccgct gattcccgct atgatcgccg gcattctctg ggtgatcgcc 3831481 gttgcttata tcctcggaaa gaaagagcgg aagcggctcg gcgtcatttc gattgatcac 3831541 gcaccgtctt ccgacccgga ggccgcaccg ctcaagcgtc ccgctcttca atggtttaac 3831601 ctgctgctga ctgtcgctct gatggccgca ctgatcacca gcctgctgcc gctccctgtt 3831661 ctttttatga ctgcgttcgc cgttgccttg atggttaact atccaaatgt caaagagcag 3831721 cagaaacgaa tctcggcgca tgcgggtaat gcgttaaacg ttgtctcaat ggtgtttgct 3831781 gcgggcatat tcacaggcat tctctccggc acaaaaatgg tggatgccat ggcgcattct 3831841 ctcgtttcac tcatccctga tgccatgggc ccgcacctgc cgttgatcac tgcgatcgtc 3831901 agcatgccct tcaccttttt catgtcgaat gacgcctttt acttcggtgt ccttcccatc 3831961 atcgccgaag ccgcttccgc ttacggaata gacgccgctg aaatcgggag ggcctccttg 3832021 ctggggcagc ctgtgcatct gctcagcccg cttgtgcctt ccacctatct attggtagga 3832081 atggcaggcg tcagctttgg cgaccatcaa aaattcacta ttaaatgggc cgtgggaaca 3832141 acgattgtga tgaccattgc ggcgcttttg attgggatta tttctttcta aatgtatgag 3832201 cttgatcgta gcattgagtg agtacgtgat ttacagaggg gagaagatca aataggatat 3832261 tatgagtgaa tagaagattc atgccaacaa cttctcatta caatcataag agcctgctat 3832321 attgcagcag gctctttcac atttggcatt atttttttgt atagcgcacc cagtcataat 3832381 gagcgtatag cggatttaca ccattgtagg agccaagcca ttcatcgaca cccgtgccat 3832441 tccacaagtt catcatgatc tttccaggtg ttgtcggaat ttggtttgtt gcagtatgtt 3832501 ttaattgccc gtcgacatac catttaatag agtttggctg ccaatcgaat gcatacgtat 3832561 gataggcatt ggctgcatca aacccgagat caacaatctt ctcatggttt cctgcaccat 3832621 ttgtataata gttaaattga accttcgttg tgtcttttcc taaaaattcg atatcaatct 3832681 catcccaagg agttccatct gttggacctg tgtaagtgaa gaacgatgaa acgatccctg 3832741 tgtttttagc tggtttcatt ctgacttcat aaagtccata gccatatgtt tgaacagaac 3832801 ggttttcccc gcagtcaaac ttgttataag ctgggcttgt tagcgctaaa cgcatttcac 3832861 ccaatgacgt cattgatacg ttattagccc gccacgtgca gttgaacata tttccattcg 3832921 aataaccatc tgctttttgc caaaaaccgg agttatagcc gttaaaaggg tcaaaaaacg 3832981 atccacctgt ttgagctgag gcagtagcag tgactgcaaa caaactcata aacaatccag 3833041 tgacaagaag cagcaacact cgtttcagat aaggcatatt ggcattcccc tttcattgaa 3833101 agcgttttct atgttgatct tacatgattc ttttaaaagg gaacatcggt caaaataatg 3833161 ataatatcga atcttactaa cttgaatcct gtaactatca tcatcttccc tctgaaaaaa 3833221 ataaaaacct aaattaccat cagcacagac agagatgatc cgcactcatt gcaatttagg 3833281 ttttgcctgc tttatcagta acaatcctac cattttcata tgtgaatgta agaaaaagtg 3833341 aacacaagga aacacaaatg tcagcgctct cattatgctt gtttaactac cctttctatg 3833401 tgaatggtta aatacagcag ctcgtcactt gtgagcttgt gctcatactc ccgctcaatg 3833461 taggtttgga ttttcttcgt gcattcatac gcgcgatgat acttttcttt cactgtatcc 3833521 agcaaaaaat cgtcctggct ttccatgtga gtgccgttaa atagacgctg cgcgaaaaac 3833581 tttaagtggg tgacgaaccg ataatagtga agcgattctt cgttgaattc aatcttaaaa 3833641 tggtatttta caatactcaa aatctcttgc atgacttttg taatgttgat aatattgggc 3833701 atctcttcat tcagctcggc atttacaata tgcagagcaa taaagcctgc ttcatcctct 3833761 ggcagagaca caccagtctt gttttttacc ataaccaacg cttctttgcc gatcgcaaat 3833821 tcgtctttgt agagccgttt tgtttcccac agcaaggcgt ttttgatatc aagccctttc 3833881 tggttgcgct ggatggcaaa gttaatatgg tcggtcagcg acacatagat gctgtcgttg 3833941 agctttttgc cgagctgtaa ttttgcgtag ctgataatct cttcggatac ttccatacac 3834001 tcgatcggta tatcatacaa aagggttttg aacttttctg atacatcctt gttatcgagc 3834061 gtgaacactt tctcaatgcg ggcttcatcg acatcatcgc cggacttttt ctgaaacgcg 3834121 agccccctgc ccatgacgac caattctttc ccctgttcat tgaccacgct gatcacatta 3834181 ttgttgatca ccttcgcaat tttcatggca tgtccctcca aatctactaa gaacagacta 3834241 tatcttgatt gtacattctt tttgtactag gtcaatatca tcagggaaag acggaagctg 3834301 gtcagtacaa ttcactccgt acctgctgcc cgggctgttt ttgaagcagc gcctccagat 3834361 ggcgttcaaa tgatgccttg tcagctttct gctttttgac aatgctgttc atgattttaa 3834421 tgctttcagc actgtattgt gtatattgtt ttttcagctg atccagctgc tgtcttgtct 3834481 tcttcgcgtt tttcggtgtg acttggttga tgagtttgat catactgtct gcggtctcaa 3834541 aaaaaccggc tctattttct gtcagctgct gaatttcgat gcggctcata tcttgattac 3834601 gcgttttttg aagcaaggca accgcctcgc tgttttgttt tttgagcgat ttgttctcaa 3834661 gcttaatcga ttcgagattc tccttcgcaa tgtctgcttc ttcttcagtc atgctgattc 3834721 gcacgaagta ttctggattg ccgattccat aatcaaatgc ttcgctcact tgtatcatgg 3834781 aactgaacac aatggccagc tgcctgtcgc ttgcgagggc ttggaaatcc tgctttttct 3834841 tactgctcat cggtttggct gcggtttgtt ttactgtctt ttgatcacag tctgcgaaca 3834901 tctgagcctc accttcactt tcgcatgcgc tcatcacaag aactgtgacc agcaggctta 3834961 tacacaagcc tattcgcctc atgctctgtc tcctctctgc tgaatccctt ctggaaaata 3835021 ccataaaata tagttaaatg gtaccagatg cacctaaccc cagcaataaa tcaaaagtat 3835081 gatttgaagc gaaaaaacat aaatattttg taaaaattga cgtgcattcc attcttttca 3835141 ggcccatttc tcgtacaata gaagtatcgt taccggagag gggctctgat gatgaaacgt 3835201 tttacgaaac aagaaaacag ctgggtgtta tatgactggg caaattcagc ttactcaatt 3835261 gtcgtgacca ccgcggtatt tccgttattt tataaatcag cagctgcgga aagcggtgtc 3835321 agcgccgctc aatcgactgc ctatctgggc tataccattg cgatttcaac gtttattctt 3835381 gcgatgctcg gccctatttt aggcacaatc gccgactatg aagggtgcaa gaaaaagttc 3835441 ttcggtttct ttgtgtcagc cggtgtcgcc agcaccgcga tgctcgcctt tatccctagt 3835501 gaacattggc tgctattgtt gctgttttat acggtatcgg ctatcggttt ttccggcgcc 3835561 aatgtgtttt atgatgcctt tctcgtggac gtcacgcctg agaagcggat gaatctcgtc 3835621 tcggcacggg gttttggctt aggatacatt ggaagcacga ttccatttat catcagtatt 3835681 gctgtcatcc tgctcgcaca agcagagact attccagtgt ctgtatcggc cgcaagccag 3835741 ctgtccttct tcataacggc tgcctggtgg gggctgttca ccatcccaat gattaaacat 3835801 gtccatcaac gctattacat caaaaaagaa cctcatattg tcatcaacag ctttaagcgg 3835861 ctcggccaaa cgatgaaacg gatcaggcaa taccgggcac ttttcctctt cttgctcgct 3835921 tatttctttt atatcgacgg agtcggcacg attattacga tgtcgacatc ctatggatca 3835981 gatttaggga tcggctcctc aagccttctg atcatcctat ttgtcaccca ggtagtcgcc 3836041 gcgccgtttt cgattatata cggaaaactg gcagaacgct tcacggggaa gaccatgctg 3836101 tacgtcggga tcgtcattta tatgatcgtc tgcgtgtatg cctattttat ggagacaacg 3836161 cttgatttct ggatactggc tatgcttgtc gccacctcgc aaggcggtat tcaagcccta 3836221 agccgttcct atttcgccaa gcttgtgcca aagcgccacg ccaatgaatt ctttggcttc 3836281 tacaacattt ttggaaaatt cgcctcaatt atggggccgc tgctcattgc cgttaccgcc 3836341 cagctgaccg gtaaatcctc gactgcggtg ttcagcctga tcattttgtt tgtgattggt 3836401 attgtgattc ttgcctttgt tcccgaggaa accagcacag atgtcagcca gcagcaaaat 3836461 gacctgcccc tttaactggg agcaggtcat tcatcattta ttcgctttat tcaccttcag 3836521 ctgtttccct ttgacggttg tgttcttcat cactttgaga acatgagggc ctttaccatt 3836581 taaaatctca acgtatgagg cgttatccat gatcgtgatg atgccgatgt cgtcagctga 3836641 cacaccgtca attttggcaa tcgttcctac aaaatcaacg gctctgattt tctttttctt 3836701 tccgccgtta aaatacagct tcataatgtc tttattcagc tcttcgcttt tgtccttttt 3836761 gctttccgga cggtcattca gtttagctag aaattctggt ttcttccttg ccacttcctc 3836821 ttgagaaggt gcttctattt tttggatttc aaatccgata tattcttcaa tgtcggctaa 3836881 aaaccgtttt tcgaaggccg tgacaaacga aatggccttt cctttgttcc ctgcgcgtcc 3836941 cgttcggccc gtgcggtgga catagctttc tttttcaagc ggcagatcat agttgatgac 3837001 aagggagata ttttcaatat caatcccgcg cgcggcgaca tccgtcgcca ctaagtaacg 3837061 gtactcgcca cgtttaaatt cattcatgac gtcgaatcgg tcttcctgaa tcattccgcc 3837121 gtgaatttta tcgcatggat atcccaagtc atccaattca tcggtcagct gattgacgtg 3837181 ctccttcgtt cggcagaaaa tgatgcagct gtcgggattc tccgtcatca gcacatcttt 3837241 cagcaatgaa aacttattct cttctcttac ttgaatcacc gcatgttcaa tatttcttgt 3837301 ggttaggccg gccgctttga cctcgatatg ctcggggttt tgcatatatt gacggctcag 3837361 cttctcgata tcctgcggaa gcgtcgctga aaacagcatc gtcgtacgct cagtcggcag 3837421 atgcttgata atcgcctcca cctgctcaat gaagcccata ttcagcatct catccgcttc 3837481 atcaatgacc aaataagaga gacgatccaa cggcagcgtg cctttttcga tatgatccag 3837541 aacacgtccc ggcgtgccga caacaatgtg gcttttttgc ttaagctcag ctttttgttt 3837601 atcaaaggag gattttccaa atacggctgt cgctttgatc cgtttaaatc gtccgatgtt 3837661 cgtgatatct tcctttactt gcaccgcaag ctcacgggtc ggtgttaaaa taagcgcctg 3837721 cggcttgttt tcatcccaat tcgccagctc acagagagga atcccgaacg aagccgtttt 3837781 cccgcttcct gtctgtgatt tgacgacaag atcctttcgt tcaagggcag cggggatcac 3837841 actctgctgc accttggtcg gttctgtata tcccagtcct tccaatgctc gtaaaatgtc 3837901 atgactgatt tgatagtttt taaaatgact catgtataaa ctcctgtctc ttgcagatgt 3837961 tctcattata ctctaattga ccaaggcata tgtgttttgt cgaaaaatga tgtattaaaa 3838021 gccagcgatt ccctggcgtt ttagctcctg aacagccaat cgcgccagtg cgtcggcccc 3838081 cgcgcgattc gggtgcagcg tatctccatc catataaagc ccgagtgttc tttccggacc 3838141 gatcgatgta aagtatgccg agctgaggac atttaagtca atgagatatg ttttttcctc 3838201 ttcggccaaa gctaaaatag aggccctgta ccatctgttt acagacgaat ggatgccttc 3838261 agaagtaaaa tcggttgccc ggccctgagg cgttgatagg atgacgtccg ctcctttcgc 3838321 ttttacctga cgaatcatat cacgcatcac ctctttaaac tccgcttcag attctttatg 3838381 cttcggattt gtgtcattaa tgccaagctg caacataaaa taatctccgg gtttaatata 3838441 cttcagaatc gcctcaagct gtccatcatt tctgaaccct ctcgcgatct gcccgccaga 3838501 cgccatgttt ctcacttgaa aggtgtgttt atcgatatag tgaggcagca tctgccccca 3838561 gcccgcctgc ttgctgctgt tgagcggata ataattgcac accgtcgagt cgccgccgac 3838621 ataaatggtt cgattcgtta ccggctgatc agacaatttc tttattttca aggcgctgag 3838681 cgtaaaagcg gtgcctgcct ttccctctgt caccagcaga ttcagctgcc cgtcggtgac 3838741 gggaatttgg aacgtatcct ccgcgccatc ccctgtcata ttgatgacct gaaacacgcc 3838801 ctccgctgcc acactggccc ttgccgtatt gccaagcgtc accttcacct cataaaggcc 3838861 attcgggaga tcaacattaa acgtgttatt gcttttcgtc ccatacgcta aaaactgaac 3838921 cgcatcactc ttcacaccag ccccggatgc cgccacatcc ctcatattct ccggtgtttg 3838981 aaaaccgtag ccctttgacc ggtcataccg atcagacgcc ctgacaccaa tataaccagg 3839041 ctccatcgaa ccgcttccaa agtcaaactg atacaccttc ggctccgccg ccttcacatt 3839101 ctcaatcccg ccaaaacaca gcatcagcat catcacaaaa accgctgcca tccatttttt 3839161 catcaagact ccccctctat gaaaacgaat acattaatgc atactcggtg attgtttctt 3839221 tatgatgact gaattaagaa aaaaattgcg ttgaggaata aaaatgaggg gagagtctca 3839281 agaaggggaa aatcagtgtg acttcttgtc acacttgatc acatcccaac ctccgcaata 3839341 gaagcttatt tggttttctt cgtcatacac ataataacgg agtctttccc attgatcgtc 3839401 agtcggtaca atctccaatg caaccgaatc gatggattca aggtcatcca gctttgatgc 3839461 actaatgttt tcaaaccgca attgaatgtc acaggtttga gcagatcgtt ttcattcaaa 3839521 cacaggaata tgaatataac gatcatcttc tttcatatag aaagaaaact cgtttaatgt 3839581 aaatggacct gtatcctcat cagaaagatg ctgtttcaat ttctcgtatt gtgtgatatt 3839641 caaatgaatt ccctctattt atatgattca ccgccaatca tataaatgtc cacagcatcg 3839701 tattcaaacc atatgatccg ttcgcctgag tccgttaggc attggagctt cccttctgaa 3839761 aaatagcttt tatccggttg aggatcagtg atcagaaaaa catcatcatt gatggaagct 3839821 agcagaaaga gaaaatctgc aatatcccgg tctgcttcct gtaatatgga ttggaaatgg 3839881 aattcccttt tggccagctt cgtcaccttg taagcatgac cttcaaaata ctcggacagg 3839941 tcttctataa atgaaccagt cgttattacc tgtatcatga ttcgatcgta ggcaagccct 3840001 gcccaaaaac gataaaacga ctctgcatct tcaagttcgc atgccataac ggtttggtca 3840061 ggcttaagct cgatcatgtc caaattgcca atactgctta tagaggttat ttccataaaa 3840121 tcttcccctt atcagttgga tagcgcaacg caaatctctt gtctgacttg ttcatacaag 3840181 agaatgtgat gatacagatc cttatcgttt ttgatcatat ccggaagtat gtcaggatac 3840241 agctcaaaaa agcttttctc caacgaacgc cgctgatgcc ggggtatcct tttattcgcc 3840301 agcacataat ccaaactgcc agcaacaagc ataaaaaact catagatttc cgcttcaaag 3840361 ccgtacaatt catcagggta ctgcttttct tcaagctctc gctgtctttt tctcagtttt 3840421 tgaagcacgt tgatcctctc ccttccgcaa taatctcatt tatttcgaaa cagaataggc 3840481 ggatcattat ctatcgcctc caacagctct tcaccaaaca cagtgattgc acatttccac 3840541 gggtctccca aaagtcccca ggagaagtcc tgatgaaaaa agaaataata gtctccattt 3840601 ggaaatacgg gaacaggcca ttcgccaaat tcatccttag gcattgcctg atgaggacta 3840661 aaggtatatc cgtcatgctg ccaatctagt gcgtacatta catcgttctt tccagtacct 3840721 aattgaaatg cttttaaaat agaagtctct aaatcactta gcactccgct cacatcatta 3840781 tgaccagctt tactgctcat cgcgcttgag atatcaaaca ctcgatatgg atcaggcggg 3840841 atgatgtgat gacatctgct tccgggcttc cattttatga tcttgttcac ttctgaccag 3840901 atgcggtctt gttttgtctg acttaaagcg cgccaattca tcataatctc atccctacac 3840961 cttattggat atcctgctta taaacaccag aagaggccac tgcgtaaaca gcgtaacttg 3841021 tcagtttcag ctgttgaaca tctaggcctt caccgttcga atcacagcat gttatctctt 3841081 ccatctcttg actcacatcg gcagaaatca aataaagaga cgacttaagg tctgcactgt 3841141 aacaattgaa cgtcccaacc aaaaaacctt cttcggatat cgcgagctga tcaaatgctt 3841201 ctgagtccgg ctctttatcc gacagaatcc acacccgtct cacgaccgtt tcatcaaatg 3841261 cggcaatgac tgcatctccg taatacagca tataaatcaa gccgtttttt tctgcaagtc 3841321 cataacaatc atctacagca ggcgcatcca tttcttcaag ctttctatca atgtgtattt 3841381 ccttctgctg accatctaac gtaaaacacc acacactatg gccgttggga ttctcatcat 3841441 gataaatccc ttcatcacat aaaccgaccc aaagctgttg tttctaatcc aaaagacagc 3841501 aggaaacccc tgaaggcaag tgaaaaacac ttttcaccct tccctcttct gaaaaaacct 3841561 ttaccttcgg ctcgtacgat tcgtaataaa cgaagacata gccatctgca cattgttgaa 3841621 agagcagaat atcactgtat gaaatctgct ctttcactct aaaatcccga acatcaccgg 3841681 aaggatcata gattgtaatg gtgataccac ctttcaaccc ttttccaatg tagacacgcc 3841741 cctgtggatc agcatggaaa aaacaatctt gggtgttctc gttgatgatt ttattcaatt 3841801 ttaatttttt cattggttat gctcctaggt tcgaaatgaa atgataagaa taaaccattt 3841861 attagctatt agtaacggac aacctagttt cattaatcgt tttgggataa atctactttc 3841921 caattcagcc ttaaatcatt tagtgtttaa ttggtatgca taaaacgatt gatcatcaaa 3841981 gcgaactgtt tcagcttcta tagcaatcag cattctgttc atgtcaataa gaaagttagc 3842041 atttgattga tactccggaa ttatagaatt tgatagattc ccgattcctt ctggatgata 3842101 actcatctca aatacttgcc aattgtattc ttccggatct attttttcca atctcatgtc 3842161 gccaacatct gcactataat aagcggatgc cacattttga aatgaaattt tatgcgtata 3842221 ttcaccttca tcttcaaaaa ccttaatatc aagtgagagt tcttttttaa acacattaaa 3842281 atctaaatga aggacactgc accccttatc tatataatca acccattcat taatcgtttg 3842341 atacattgtc atcccctgcc tctttttaaa caataacgcc ttgccaccaa gcagaaaaca 3842401 aattactccg tatattgttt gatccaatca tttaaatcat ctgttgaatg caaataagtt 3842461 tctgatgaat ctttcaaatc aatcccactt agaaggatta acatatccca gactctatcg 3842521 tcttctactt cggggtcatc cgcataaaca taagttccag cccaatccga cacttcttct 3842581 cttgttgttt gtccatttaa gacacttttg attttattta tgcattctat tagatttgtc 3842641 tcgctcaatt tgatcaccac gtattcaagt actaaatgat tttttattag tatgcaaagc 3842701 accgtactga tatttagata ttgaagcttt ttccgtaaaa gatatgttcc aaaaggtttc 3842761 caatctacca ataaacaagc tcacatccgt attccgtgtg caatatacat aaaccaaact 3842821 ggcacttagg ctcaaccaaa ataaaactat gattgagaat cccttcatcg aactcaatac 3842881 actccaataa gcagtcaagg tgctcgagac attttccaaa agaacaaact aacgcaccaa 3842941 tttcgctgct gtattgatga aacagcagaa cgtcccggtc atcgtaagca acatatgact 3843001 gagatatttt ccagatcagc tgtttcgctt ccgttttttc gagggcatca acctcacggg 3843061 tgttggctgg tattgaattt gataaaacca gctcaagcaa ttgcctgctt tgcgccagat 3843121 cagcaaaacg ataagtgaag cctctttctg cacaagggac tagtttttct ttgatttcgc 3843181 tcatcaataa acgtctttta ttctcggcga gtttttcgat caatcttttt tgcatgagcc 3843241 gcattccctc cgctgtcaat ttctcaactt cttttaaatt gattcatcat tctcttgttt 3843301 tcgttgtcgt tcatgtttag atttgttcta aaaaagcttg tatcgcttat cgatacaagc 3843361 tttatcttca actgcttaaa actcacccag tgggcttttc acaaaacgct gggaaccttt 3843421 ttggcaaatc ctcttcatcc caatcaattc tatattttta gattcttttg tcatacaaat 3843481 aagagaggat ggtaacatct cttatttaat gttccatcaa taaatgcccc atttttatcc 3843541 aatgcagaaa ttatttataa ttaaggaagt ttagaaggat tttttgtatt ttcaagattt 3843601 aattttaaag cggtcacaaa agactctagc ttttcttcat tacaattaat ttcgaacaag 3843661 ttggagttcg acttactttc tttataatca tcaaatataa ttttaatctt aattctgtaa 3843721 tttccgtttt cttgatcaat actaagaaat aagaatggtt caatagtctc taaactgata 3843781 ctgtcttgat ttccttttat catagtttcg atcccagata tcaacacctt atattcactt 3843841 tctaataaaa cagcagaaaa atcgcgaacg acggctttct tattttccaa caattcaaat 3843901 acagataaaa taaatggatc atcgtccaac tcttgatacc ttctcggtgt taattcaagt 3843961 tctatacaat catcttttat tttggccata tttcctcctc atttaaagtt taagtgaggg 3844021 tagttgtcat ccccccctcg cttaacctta ttaacgcctt ctcttagatt tatttccttt 3844081 tccgtgtgta tggaatacgt gtttagaacc cttagctctt gaacttccat aagctgtgat 3844141 tactttaccc cttttattta aaacaactgt agcttttttt ccaacatatt tcgttgcccc 3844201 attaggttgt tttattactt ttttagggct tcgcacagca ttcagtttgg cccttaaatt 3844261 gactccacgg cctccatttc ttcctataga ttgattaagt ccatgtcttg tatgacctgt 3844321 gattttaact gccttcttcg taaacttata ggcgcgacta gcacccttaa atatcttccc 3844381 aggaccaaaa ttagaagcag ctgcccaagc agcacctttc catcctttac ctgatttata 3844441 tgccttatat ccatcatagg ctgcaaatcc ggcatttacc acaagccata cccaatgccc 3844501 gtccggatca acattcatca ctgggttatt atttccataa gcatacccat tctgatccaa 3844561 tgaatctccg tcgctgcccg ggtctgggtc gagcgatagg aacacgccgt ttcttggctc 3844621 gtagtagcgg gccatgagat agtacaggcc ggtttcttcg tcgtattggt agcctgcgta 3844681 gcggtagcga ttgtctttta cttcgtcgct tgcttcggtt tttgttggat ttccccatgc 3844741 gtcgtattga tacttggcaa cggtttttcc agtgctgtct gagatcgcga tgatgtcgcc 3844801 gtgagcgttg tagtgataga aatatttctt accattttct gtgtaggata acagctggcc 3844861 gctgtctccg tacgtgtatg attttgtgac gttgttgtcc gcgtctgttt catacaagac 3844921 gttcaagctg tctccgtcgt agaagtagtt cgtgactttt ccgttgacgg ttttttggat 3844981 tctgtttcct ttttcgtcat acttatatgt tgcgaatggc ttgtcttcgc cttttttggt 3845041 aacggcggtc aggttatctt ctgcatccca cgtatatgtg aatttgccgt cggatgtgcg 3845101 gttgccgttt ttatcgtaag agatgctttc atcattgact tttgtcagct ggttcatgat 3845161 gttgaaggaa gcgttcaccg ttttgcttga gccgtctttt atagttgtaa cggttttccg 3845221 gtttccgaat ccatcatatg tgtattcaat aacagtaccg tcttcatggg tttctttgac 3845281 aagctgattc agcttcccat actcatattg caccttgccg cttgctgagc tgtttatcgt 3845341 tgtgcggttg ccgttggcat catattcata gctttccgtc agaatgtctc cgccgttttt 3845401 gtcaccgata tgcagcgagc ttacaaggtt tctttcgtca tatgaaaaac ttgttccgcc 3845461 gccgttgccc gtaataaagg tttggacgtt tccattttca tcataatcaa atgaatatga 3845521 ggatgtactg tctttcatct caatcatttg atccagcttg ttatacgtaa attgattcgt 3845581 tcctttttgg tccccatgaa tccacgagaa ggttttcagc ttatcggagt cactaggata 3845641 tgtccaagtt tggctgccgc cgcggtctgt cagttcggtt aaacggtttt tgttgtcaaa 3845701 tgtccgtttc tttgtggtgt tctgctcttt attgacgacc gacgtttcat ttccattttt 3845761 gtcatacgtg aaaatgtact tttctgtacc gttatacgac tttgatttca cccggtctgt 3845821 tccatcataa gaaagagaca cttcgttgcc atttggtgaa atggttttgg tcaggttgct 3845881 gttggcatca tattcgcttg ctaacacatt gccgagaggg tcagttgttt tgacaagctt 3845941 gcccatgaca tcatattcga atttataggt ttgatctgct cctgcccgga tggttttgct 3846001 tacctcattg ccttccttat catagctgtg aaggatagac gtgccgttag agagcgtcat 3846061 gtttgtcaat tggtctgcct gatcatacgt ataggttgtt ttttcacctt ttgcatctgt 3846121 ttcagacgtt ttcttaccag tttcatcgta atcagttgaa gtggcgtaac ctagttcgtc 3846181 ctcttccttg gtcacatagt tgccattact gtcatacgtg cttttagtca gaaggcttcc 3846241 ttcaatcaaa cggatatcat caaaccagac tgtgcctgtc gcactctttt ggaacagaat 3846301 actgatatcg actttattga tcggctttgt tttagggatg acgacagctg ctcggttcca 3846361 ttcctgtgtt ccagaaggga atttcgcatt gtagatgcct gtgctgccgt cagcgtaagt 3846421 gacattcgcc tgcagagaat agtctttttc atctgtaaat ttgacgctgc ttgctttcga 3846481 cattcctgtc agtgtgagat aaaccggttt gtcatttgcg ctttgcccta agacaacggt 3846541 ttgttttgtt actgatccgg cttgggacgc actggtccgg gcagctttta atgatacatc 3846601 atcattaaag ccttcttcag aatcaacgga tgctccgctt acattccagt tttccgttgc 3846661 tgatgtgaag ctgctgtttt gaactgggtt atagcttgat gatacttcgc ctttttccag 3846721 ctggacttca tcaaaccatg cttttccttt gccatcttta tctttatgat cgacttccat 3846781 atacacaaca gctttgcctg cattcgctgg agtcgtaaaa gtgatttgcc gttttgtcca 3846841 gtcatttttt ccggctaatg cactgtattc attgtgaatc cattgaattc gtttttgatc 3846901 tttgtctcgc aaatcaatgt taaaataggc tcttgatttc gcaagatctg ttttgatttt 3846961 cccgcttaat gtataggttg tattcggctc cagctcaact gtttgtgttg ctgacgaata 3847021 cccatgatct gttccggcag acgttgattg gctcaagacc tccaatgcct ttgatccgga 3847081 aagaactccg cttttatcgg cgatgactga aattttgccg ctgtctttag aggcagtcag 3847141 attccagccg gatttttgag cttcaaagct tccatctttc aaaatattag ttgaagctga 3847201 taaatctttg ctcgattgaa tctggtttcc atatttatca taaacagctg ctgacgatga 3847261 ttttccgctc tgatcggttt cggatacagc atccagtccg tcataagcaa tatccgtgac 3847321 attgccctcg gtatccttca tctttgtgac atcgttgttt ttgttgtatt cgtatgtctc 3847381 agttccatat gcatctttaa ccgacgtaac gttgccatct ttgtcatatt gatagctttc 3847441 cgttgctttt ccggtgccga cgtcatttgg atctacatct tctacaacat tgttgccttc 3847501 atactttgta ttcgttgtaa tttttaaccc ttccgcatca tcaatgacct gaatcggatt 3847561 tcccgcttca ttatagccat actgtacttt ccggccattt ggctgtgtca tgagaagcgt 3847621 ctttttatca gcatcatagc tgtagacata tgtttctttt ttagcgttga tcgctttttc 3847681 gagacggtga ccgctatact gatattcggt aaagacaggc tttgcttcgg tactgttagc 3847741 tgaatattgt ttgacaaggc gcccttcact atcgtagtca tagcttgtga cagtcccgtc 3847801 tgtatctgta accttcttca gcaaatcatt ctcatatgag taggtgactt tcttattctt 3847861 aggtcctgtg atggacgtca catggccgtt ttcatcatag gtaaatgtaa gcttgcggcc 3847921 tgatgcatct gtaatggcgg tcagttgatt tttgtcattg taagtataga cagttgcatt 3847981 gttatggcca tccactacct tttggagttt gccgcctttt ttattgaaat aagcgttggt 3848041 ttgatccttt gtttttaata tgaactgatc agctgtttct gttaattcaa gatatacacc 3848101 ggtcggcggc tgatacgtgc catcggcttt tttcgtgaat cgatgtgtcg tagcgtcttc 3848161 atcgatatac attgccccgc catccgttga gatgacagat gtttctgcat cagcatacca 3848221 gccttgtcca aataagtgat cagagctgtc aagactgttg taggttctcg ataagccaag 3848281 tcccggaccg cgtccatcaa ttgacaaatc ttcttcattc acaatgacat tgcctgtcgc 3848341 accatttaac tggccgcttg ggatatcaat gatagaccag tactcttctg tacctaggaa 3848401 ttctgcgcct tcatggaacg ttgggttaaa gggcgccgtt ggaatcgttt caccattcgc 3848461 atcataggcg acaagcgtga aagaataatt cttcttccct ttgtaattcc catttgcatt 3848521 gttatagaca ggtgatggat cgagggctaa ttccccgcct tttccatctg tatgaagctt 3848581 atagcttccg gctttgattt cctcagaagt cggccagatg tttttatttt gggttgtcca 3848641 atgatcagca tcaccaacat caaaggactg atattcttta ccgttgtaaa tgttaacttt 3848701 atagcccttc gcattttgaa ccttttccca tatcaaattc acataacccg tttgactcga 3848761 ttttgtattt gtatacaaat agccagttac attctttggc ctagcgatat caggaagtgc 3848821 cggggtagca gccggggatg caatggcttc gccgtctttg ttgtatgcga taattttaaa 3848881 cgagtaattt cttttggctc catctccccc ggcgttttta taggttggtc cgggattgat 3848941 cggcagctct gctccgcttc cgtcctttag gtgaagagca tattttcccg ccttgatttc 3849001 tgcacttgtc ggccagatct ttttcccttt tgtggtccaa gacgtctgat ttccgagatc 3849061 aagtgtctca aagcctttcc cattgaacac ctgaacctta tagccggttg caccggatac 3849121 agctttccaa gaaaggtcga agtatcctgt ggcattccca ttattgtagc cctttgctga 3849181 cggtgcttgt gcttttccta cattagggat aacgggcttt gccggtgcgg acatcgctcc 3849241 ttcaccttgg tcaaatatcg cactgacgcc aatccaatag tttttgcttg tagcatagct 3849301 tccgccggaa ttcttataga ccggggatgg atctaatgcc aattcagctc catccttgcc 3849361 gtccagatgc agtttatatc tcttggaggc aatttctgcg ctcgtaggcc agattttttt 3849421 accttttgtg ctccacgacg tgacgttgcc tgcagaaatc gcttgatatt ccttaccatt 3849481 gtaaatccat accttatatc cttttgcgcc ttcaaccttt ttccagctga tatcgaaata 3849541 accagtggaa tcgccgttgt gataggcttt gattgtaggt gtgtttccct ttggaatggt 3849601 atacgtcact tcaatatatg gtttattggc ggagttcgct gaagaaatta gttttttcca 3849661 atattccttg ccgtttccgt ttgtatgaag cttaaatcca tagttggccc cgccggagtt 3849721 ccatgacttt acagcagcgg tcacatcata actcgcccac tgtcctttat ggacgtcggc 3849781 ttttccgata tttttagatg ccggtttggt gttccatgtc acttttgcat tatcataatt 3849841 gctgttgacc gtatccagcc aaaggccggt tgcctttgtt ccataatagg aatgggctac 3849901 gtatgttttt aatgtagctt tagtgacagt catattttga attggcttta ggttgttaaa 3849961 tttcatgaac gcatagtttg tgcctgttgt tttgtcataa tagcccgttt tcagtacata 3850021 ggcctttaaa ttagcatccc atttttgtga ggaggccgaa tagttcgtcg tcgggtaggc 3850081 actcatgaca aacgtatccg atgaaacaga taaagaagtt gacgggtcga tagatactgg 3850141 atatacgcgt tctgggtctt tcagccagtt ctcgtctgcc gtaagatgaa gcaaataccc 3850201 ttcttcattc ttttccagct tatagctgac tttgtctgac cgttcaacct cgccggaaag 3850261 ctcatctagt tttgaatccg tcataaaagg cttaggcaca gaaaaaacaa cttttccttt 3850321 ttcatcagaa aaatcaatgg atccatcctc ttgttcttta gcctgcaaat cggtttttaa 3850381 ctgaaatgta aatgtgttgt atccattata ctgatgaagg actaaatctt cttttatgtt 3850441 ttcattgaat gtgaaagtct gaagatcaat attcggaaac acatccggat acacaatctc 3850501 attactgtca gtcttataat ctgctgaggt atctttcgga gtaagtgaag ttttattcgg 3850561 gcctttcgct tctgctagtg aatatgtaac cttatggtca ttatgctcaa aagtcgcata 3850621 aagcccgttc ttcatttgct tttgaaaatc tgaattcaaa atagcgttct ctgtctcgac 3850681 ttgtttgctt gtcgactctt ttaactcagg agaaatgtct tcccagtcgg catccggtgt 3850741 ttcctttgta tgaataggat caaggtatac ttcctgttta tagacaccgt caccttcata 3850801 atagagtttt gtattttctg ttctttcaga ggtgatctca ccctctttgt ttatatcttt 3850861 tggatcaaaa ggtacagctt cctcagtttg ttctttctga agagtttctt ctggatcatc 3850921 ggcagcaata cggtttccat tctcttcttc tgtagatttt gctagtacat cggctggcac 3850981 taatgaaatc attaaagcca acactaaaaa tgctgcaatg aaccttttaa agtttcgcct 3851041 ctttcttttt ttcatttcct ctctcctttt gtaataaaag taatatttac tcaataatct 3851101 taactagact gaaatatcat tacaatattt ttctagaaaa tttatcttat tttaaggatt 3851161 agcgagagtc aattgaccta aaacaaaaaa aggccgcata ggccttttta cattttttat 3851221 tgtatttgtt caatatccgt accctcagct gtcacattcg ccttcccctg cctcctgaca 3851281 agcgtcaagg ccatgcccgc aaagatcatt acgatgccaa gcgtttgata gaggtcaggg 3851341 cggaagcctg tgaagacggt atcgagcacg atcgcgacag cggggtcgag aaatacaatg 3851401 attgaaataa atttcgttga taaaaatcgt aaactgtcaa aaaacagcaa atatacaata 3851461 cccgtatgga tgatgccggt agataccacc ataatccagt ttccctgaga taggtccgca 3851521 aaagcgccaa agtgaataaa cggaatcagg atgataaccc ctaaacctgt ctgcaagaag 3851581 gtggtcgtgt aaggactgag attgtgaatg ccttttccca ataaagtggt gaacgcataa 3851641 aacagtgcgg cgagaactgc ccatatgatc cctgatccca tcagctgtgt caatgatgtg 3851701 ctgccgttaa tcccggaaat cagcgcagtc ccaagaaagc agatgataat ggagctgacg 3851761 gagatcacat ttaatttctc tctgtagaag aagctcccca gaagaagaac aagcaccggc 3851821 gctagatgat aaacagagat ggcaattgta acggacgttt cttcaaaaga cttaaataag 3851881 aacacccagt tgaatacaag aaagaaaccg cacgccaatg tttgcagcac gtctctcttg 3851941 ctccattttt cagttttata ctggccggac gccagccagc aaaagcctaa aaacagcgtc 3852001 gcgcaaaggc agcggacaaa gaccaattca aatgacggca gattggtatg ctctgagaaa 3852061 aagccgatgg agccgaaaat caccatagag atgaccattt tgattacggc tgttgatttt 3852121 tgttttgacg atatggaagg atcctgttgc atcaaacgta ttctacctcc aatactgcat 3852181 agcataaact gttttttgtg aattcagaaa tctacacata gaattcctct tttttacatg 3852241 tagatattat aacacttcta ttctaaataa aaaaaagcgc ccaagggcgc tttttttaca 3852301 aatctatcga acaatcaaaa ccgggcatgt tgataattga gacactttat ggctgacgct 3852361 tccaagcatc atttctttca ggccgctgat cccccggctg ccaactacaa tcaggctgac 3852421 gcctttctct tttgcgtgat ttagtatctc atgcgccggc tcgccattcg cgtaaatggt 3852481 ttcagcttga acgccttttt cggctgcttt ttcttttgca ttctcaagga ttttcaggcc 3852541 ctctttttta acctcgttcc tgatttcatc aataaagtgt tcaggcacat agacaattcc 3852601 cgtcagagaa gaagtcgtga cgacggcttc tctccccaca tgaagaatgc ttagttccgc 3852661 ttgttgctct tttgccaaat gcactgcggc atcaagcgct tttgcactca tgtctgatcc 3852721 gtcaatcgct actaacattt tgttaaacat gctcttcccg cctttcggac tgtgggtggt 3852781 tcatctttct cttttattgt ccgcctgcat ttcgttattg tcaattgaag cgcatgagtt 3852841 ttcaaaaaat tgtcagagac tctctccgtt tgtggcgata acctgctgat accagttgaa 3852901 gctttttttc ttgatgcggt taaatgttcc atttccttca ttgtcccggt ctacataaat 3852961 gaagccgtag cgctttttca tttccgcagt agatgcgctg acaaggtcaa ttggccccca 3853021 tgatgtgtat ccgattaatt caacgccgtc cgcaatggct tcgcgcgctt caattaaatg 3853081 atcacgcaga tagttgattc tgtaatcgtc ctgaatcgtg ccgtcctctt caaccttgtc 3853141 tacagcgcca aggccgtttt caacgatgaa cagcggcttc tggtaacggt cgtataaggt 3853201 gttgagcgtg atgcgcaagc ctttcggatc aatctgccag ccccattctg atgatttgag 3853261 gtaagggttt ttgactccgc ccagcaggtt gccccctgat tttgcaagct cttccggatc 3853321 tgtgctcgcc gccatcgaca tgtagtagct aaatccaata taatccaccg tatgttcttt 3853381 caagagctct tcatcgcctt cagccatttc aatttcaata ttgttttctg ccagatagcg 3853441 tttcatatat cccgggtatg cgcctcttgc ctgaacatct gagaagaaaa gtgttttgcg 3853501 ctcattctcc attgccgcga agacatcctc cggcttagaa gtcatcggat aggttgtcgt 3853561 tgccgctatc atacagccga ttttcgaatc aggaatgatg tcgtgacccg ctttgacagc 3853621 aagagcactg gccacaaatt ggtggtgtgc cgcctggtac atcgcgttta atttgttttc 3853681 tccttcttca aaaacaagac cgcctccggt aaatggcgca tggagcacta cgttaatttc 3853741 attaaacgtc atccaatact tcactttgtg ttgatagcgt ttgaaaaccg ttttggcata 3853801 gcgttcataa aactctatga ctttgcgatt cttccagccg ccataatttt tcactaaacc 3853861 gagcggcatc tcataatgag agatggttac gacaggctca atatgatgct ttaacagctc 3853921 atcaaacaga tcatcataaa atctgaggcc ttcttcattg ggctcctctt catcgccatt 3853981 cggaaaaatt ctcgtccacg caatcgatgt gcggaacgcc ttaaatccca tttctgcaaa 3854041 taaggcgata tcctctttat aacgatgata aaagtcaatc ccgttgtgat acagattcaa 3854101 ggaagtcatt gattcatcaa atggagacat gatcccgttc ggcgatacgt cagctgtcga 3854161 aagcccctta ccaccctcgt tataagcacc ctccacttgg ttggcagcaa ctgcgccgcc 3854221 ccataaaaat ccttctggaa atcgtttttc atttgaactc atattgatca ccccattagt 3854281 tttttcaaga taaagcaagc agcgcttctt ttggctgcac tttaccgatc tctttcaccg 3854341 gcgaaaacga atattggtct gtgttggtca caatcaccgg ggtaatgacg tcatatcccg 3854401 cggctttgat ttgctccaga tcaaaggaca cgagcggatc tcccggtgcg accttgtcgc 3854461 cttctttgat gtgagccgtg aaccattgtc cctccagctt taccgtgtcc aatccaatgt 3854521 gtatgagtat ttcagctccc tgatcactcg taatgccaat tgcgtgtttt gttttaaaaa 3854581 tggtggtaac gcttccacga acaggcgaaa caacttctcc ttcttcaggc tcaatggcaa 3854641 atccttttcc catgacccca gcagaaaaca ctccgtcttt gacttcactt aaggctttca 3854701 cttctccctt aatcgggctg tgaatgatct ctctgctgcc ttcatgcact gccggctgct 3854761 ggctgccgtc agaaggcaca tcctcgaatc caagcaaata cgcagctgct gttcccgccg 3854821 caaacgcaat cacaaggccg atcatcgcgt aaataaacgt tgggccgata aagacaggga 3854881 tgctcggcag acctgcattc cccccgacga tataggaagc aacacccgtc atgccgtaaa 3854941 acgcgccacc ggctgcaccg ccaatcaaag cggccgcaaa cggctttttc aatcgcatat 3855001 tcacgccgta catcgcaggt tctgtgatcc ccatcagcgc cgtgatgctt gtggtaagcg 3855061 cgagtgattt aaattttttg tttctagagc gaaggaagac ggcaaatgat gctcccgcct 3855121 gccccatatt cgccaaaaac atagccggca gtaaataatc gtggccgttt tgagcgatgt 3855181 tgttgatcat gatcggcaca aaggcatagt gcatgcccgt cataatgatt aaagagaatg 3855241 tacccgccag caaaatcatt gccacaagcc ctgcatgatc aaacaaataa ttgaccccag 3855301 aagacaagta ttctcctaaa atagcgccaa gcggaccgac tgtaatcaat gtcagcggca 3855361 cgacaatcaa tagcgtgaat gtcggaacca caatcaattt gagagatgcg tgtgtaaaac 3855421 ggtcaatcca tttttccacg tatgaagcaa tccaaatcga cagcaaaatc gggatgaccg 3855481 ttgacgaata agtggcagcg gttacaggaa gcccgataaa ggaaatcggt ttccccgcac 3855541 cgagcagggc tgtcaaatcc ggatgcagga tcgccgccgc aatggcagcc gctacgtacg 3855601 gattgcttcc gaattttctc gccgcactca tcgctagcag gagcggcagg aagtagaacg 3855661 caccgtcacc gacagccgtc aaaatgacat gaacctggct cttctccgcc atccagccaa 3855721 acgtgactgc cagcgccaca agtcctttga tcatccccgc tcccgcaatc gcaggcagaa 3855781 taggggtaaa caccccagaa atcacatcaa agaccgcact cagcacattc tttttctgag 3855841 aggatgaacc agcgctcttt tcatcactga gattgctgtg ccgcacaatc gcctgataca 3855901 ccttcggcac atcgtttccg ataatgattt gaaactgctc gccgctgata ttggtgccca 3855961 tcactccagg cagctgctcc agctgactgc gatccgcctt cgcgttgtca tgaagattaa 3856021 aacgcagcct cgtcatgcag tggatcacgc gctgaacgtt ttcttcaccg cctacgagtt 3856081 gtaatatgtc cttcgataat ttatcataat ccatgtgtat acctcctttt tatgggggga 3856141 ctgctggatg aaaggtggcc gcctttcacc agcttttttt gtatcaaatg ctgcatcacc 3856201 tcctaaaaga gaataaaaaa acctaaatga cacagattgc gagagtctcc tcctgcacct 3856261 gcaccattta ggttttgcct gctttcgcag taacaatcct gacgggtcgt tttatttgtt 3856321 tgtaggtata ctttagcact agattcgtga gatgtcaacg ctttcatttt tggtgttgac 3856381 tatcgtttct agaacaaaag taatcataaa gatttgaact tagtattaac ttcaataaaa 3856441 aattattgta attaaaaacc ttgaaaggca ttttttccaa tcaaggttat gaatcgttac 3856501 cgtttaaatt tttttaaaga cttctttatc tgtactatta cattctttag ccaatctatt 3856561 ggttctaaat taaacgcagg aagatacacg ccatctgcgc aagattgaat gtaatcgttt 3856621 ttcttattgt ctgaatgctc actttcaata aaatccgtta aaaagacaat agcatcctcc 3856681 aaatattcct tactttcctc tattaataac tcttgtatag cgtcatcagg agtttcaata 3856741 tcttgatgga atgttccagc taaaaactga aaaacagggt ccttctgttt attgatcaat 3856801 aacatgtcat cttgctcctt taagggagag gtaacgggat aatgttaaaa tcattcatca 3856861 tctaataaat caagataata ctgatcattc tcttctattt ttcttaagaa ctcggtaaga 3856921 gaagttgcaa tttgaatatc ataatagtaa atcggatttt tattattatc atttaattca 3856981 attgacatta atgccgattc actaccttca aaaaatatta atttatcatt ctcaaactca 3857041 tcatatattt ctatgtcagg ataaaattca aagtcattta tcctcaatcg aaagtctctt 3857101 acagaatatg gatccaaaat gcgattagta ttaaactctg atcctttaat aaacccatag 3857161 ccaacttcta aataaaaatt cactaattca ctaggtaatt ttaagtttaa atttttttca 3857221 acctcttcaa tctcactttg attcactgga taaaaatcat tttctttgtt tgattttata 3857281 aaattataac tcattttttt ttgcctcctt taaataattc atttgctggt gagcctgtac 3857341 catgaatccc agcttgatgc tcgttaggaa attttgctgg atgcatattc caccattcat 3857401 gttctccgcc aaaagtattt tcaattatat ggtgagcatc atacttatcc cctttttttc 3857461 taataatttt acctgttttt tcagatacaa cattttcctt ataaacaggc catttttgtc 3857521 cagtgttttc ttcccattct tttataactt tattttttac tttatcaaat ttagtcctgt 3857581 gttttgcagt ctctattggt gacatttttt tatattcttt atttcttaat gcttccttta 3857641 atttatctat ttgattttta ggtaattctc tacctgtgcg ttgttctata tctctagcat 3857701 acttttttat taaatcagaa ttaattttat tagcagatcc acttacatca ttcgcaattt 3857761 tccctttatc cttagcaacg tttttaactt ccgaagcctt cttagccttt ttcccattat 3857821 taataagttt attaatatct attaactttt ctaacttagc tattttggca aatggtactg 3857881 agtttatgga ggcaacaaca cggtctttcc ctgtgacttt ttcgcctgat accggatctc 3857941 tgcccgtggc tgctttaaat agatcataca cgccggtaag ttctacagcc gtctctaaaa 3858001 ttttcacata tccattctca tccactttaa tgtccgaaag cgagacgaca ggttcaagct 3858061 tcatgtcatt accagatatg tatacattgt aaagtgtatc attataaacg acttgcttaa 3858121 cctctgcatt tgagaaatca gtttttatat gttctctatg ttcactcgta ttatacactt 3858181 taccattgat aacgatgata tttttactta cctttttaga atcacccgtt ttgacaactg 3858241 aatccacttt agacttttca ttctcggcta atttcttcag catcatctcc atcggtgaat 3858301 catccgcctg cttcatttgc gggttaatcg cgccgaagat ttggttgatg ttttcttctt 3858361 cctgtgattt caggatggag ccgcttttgt agcctgtgat ttcaattttc gggccggtgt 3858421 acatggtttc gagctgatca atgtattttt tcatcgtttg aaaatctgat tttgcggctt 3858481 ctagtgcttg ggtttgctgg ccgtcaaatt gaaagagctt attcagggtg tctgaaatca 3858541 gccgctcagc ctgttctgtt tccatccgaa aaaaggaatc attgactgtc ggcaggctga 3858601 cgatgtgatc tatggctgat gtctggcgat tgactgcgtc agtgagctgc tctgtcactt 3858661 ctcgtgcatg cttgacccca tgtctcgcat cgtgtgagag aaaagcctct gcgatcatgc 3858721 cgtgggagtt agattctaca gaggaaatcg catgctgtgt ttgtttcagc acttttttgt 3858781 attcgtcgat aaatatgcca aagaaaagga gaaaaggctt gtggcactcc tcgtaaaagg 3858841 tccggatggc atctccgcct tttcctttca gcgcatcctt catgcctgcc agatgctcaa 3858901 cgcttttttc cagcttctcc agctgttgtt tttgcttgtc cagtttctca atcgtatgct 3858961 gaatgccctc gtgaagagcg tggacatcta atgttttcaa tcccttgtcc tcccgcgctt 3859021 tatttcatgg aagatgatat gttttcgtcc gtttccttca tggcgtttac cgcgctttcc 3859081 gtttgtgcga tatgcttggc cagaacagac gcatatgctt cagtgagctc tttgatgtcc 3859141 ttatttaatt gctcgatgga cttcacaaca ttcaaatggt ttctgcctga gagatgaccg 3859201 ggcaatgagg acttgagttc agctgaattc ttgagctgag aaagcccttg cttcactgtg 3859261 tcatacacca ttttaatttc ctgtgccatt tgtgctcacc tcacttttta tgtttttcct 3859321 tctctatttc atgctctatc ctcgtgattt ggcgtcttat agaatacaca tcgccctcta 3859381 atgagtggat ttttccttct atgctttcga tgattccgct gacttgatcg cttttgattt 3859441 gctgatatgc tttgttcatt ccttcacgaa tatcttcaaa ccgctcagca tgtgttcctc 3859501 tccatgcctc ccggttaaga tgaggccggt gaatgagatg ctgggcctca gagaaatcgt 3859561 gtttgatttg cctaatttcg tgcagcactc gttttaattg atggatctgt tcctgctttt 3859621 catgtaagtc ggcttttacc gaatgtaaca acatttcact atgcatgccg caacacctcg 3859681 tgtttctatc aaactgtgta aattctttac aatacagact attttcatat tacatgatgg 3859741 gtcatattgg ataaataggt aaaaaggatt gtcttgagag gtatagaact ggttctaaat 3859801 tgctaaaaat acgatctcat caccctatga aaggagaaaa caatcatagt agggactttt 3859861 tatttaagcc tttaatctct cctccagttc taatttttcc tcccacttaa ctgtttctta 3859921 tagtcaataa agctcataaa aaaacacctt ccctcgaagg cgcttctcca tcttatttag 3859981 atccccatac agcctcaccg ctggtattca gcacactaaa cgtcatgacg ttcttctctc 3860041 tcaccgaatc ccactggcgt aaaaataccc cgttatactt cttgcctgct aacgtgatgt 3860101 cggcggtgtt ttttccggtt ttcctccatg ttccggtcat ttccccggaa atggtgtggt 3860161 ttttgttgag ctggatgttg atggtttgtt tgatgtcggc tgagatgtct tttccgtgct 3860221 ggataagttt gtatgttcct gtgatgtctt tttgttttac ttctttcaat gtttcgcccg 3860281 cataacgata tggtgctgct accggccagc cgtctttgtt catgaacaat tggtggactc 3860341 tgacttcgtg ttcttcaccc ctgcccggga agcgggtgtg gaagattaaa taggaacgcc 3860401 cggttttttc atcatagtat gcggagttgt ggcctggtga gacgtacccg gtgccttttt 3860461 cattttctgt ttcaaaagtg tagctgccca tgagtttgac gccgtatggt tcgatggaac 3860521 ggtcgtcgaa gaatgtgcct cccttgccgc ggacgtcgag cattggattg ccttctgcat 3860581 catagtaagg gccgtccggt ttcttggagc gggccacacg gatgttgtag ccgcctgttg 3860641 catcgagacc gccatatgat aggtataagt agtagtattg ggtgtctgga ttgtagagaa 3860701 catacgggcc ttcgattctg ctgtggttgc cgccgagcag ttttttccca tatccctgtc 3860761 caggaagcgg gaagcccgtt ttcggattca tttcaagtat gaaaatgccg cctgagtatg 3860821 atccgtacac catccacagc ttgccgtctt tatcaaagaa ggtatgcggg tcgacgacat 3860881 tcggatgttt ggttgcatca tacggtgttc catcgctgct tgtgccttcc attcctgatt 3860941 tcaaaaagat gcctttgttt ttgtatgggc cttcgatgtt gtcagcaacg gcaacaccca 3861001 tggcggatct tggcgaatcg ccgcggcagg cgttgtagta catgtagtat ttgccgtccg 3861061 ccagctgcgt gacgtcagcc gcccaaagag tatcggattg cgcccattcg aaggtttctt 3861121 ttaattcttc atagacattc gggataagtg ggttgtcatt gcttacgctg gtggtcagct 3861181 gctgccattg catgaggtca ttcgatttag ctgaagcgag atgagatcca aaaacataaa 3861241 aagtgccgtt tgtttcaatg atggaagggt catggacgct gacttcttta aatataggtt 3861301 tttgtgcata gacggagttt gggagggtga aggccatgat aagagctgca agaaaacata 3861361 cacggaacaa tcggttgaac atctaaacaa ttcgcctctc ttttttatta aattttaaac 3861421 gcttacattt ctctatgaag ataccccggc ctattaaaac agccgaatgt tttcatattc 3861481 atccagatag gtgatttctc acttcactta catagtcaga ctgatgtctg tctgttttgc 3861541 gcagaacttg ttgcttgcat atcctctcct tcatagttca actcttttgc tgtttctcct 3861601 tcttgcatca cgtctgtttt tctttcgcgt acatgtaata actgctttgt caggttttgc 3861661 atcaactgtg atacagccat ttcgttgtcg gcgtttttta agatgatgcc tgattgcccg 3861721 tcaacaccag agtcattcgg ctggctcttt ataaaacgcc ttgcgaaaaa tacgacttag 3861781 taaacgcata ttgagagtta gacagcggcg cttgcctcct tgtctggata tcgtgtgcaa 3861841 tcgctgaaaa aacctgttct gctttctgcg tcacgctatt acaatagcaa tctaacttgt 3861901 taaagactat aaaaaaacct tttgacttct gctgctgaac caattaatat aatactcagt 3861961 taatagttat cagaattttt aggaattgag tgattcatat gacactgcat aaagagcgtc 3862021 ggatcggccg gctgtctgtt ctcctgctgc tgaatgaggc ggaagaaagt acgcaggttg 3862081 aggagctgga gcgagacgga tggaaggtct gtcttggcaa ggtaggatca atggacgcac 3862141 ataaagtagt agccgcaatt gaaaccgctt ccaaaaagag cggtgtcatt caatctgagg 3862201 gttatcggga gtcacatgcg ctttatcatg cgacgatgga ggctttgcat ggcgtgacca 3862261 gaggtgaaat gctgctggga tcgctgcttc ggacggtggg attgaggttt gccgttttga 3862321 ggggaaatcc ttatgaaagt gaagcggaag gcgattggat cgctgtctcg ctttacggaa 3862381 caatcggggc gccgattaaa ggtcttgagc atgaaacatt cggcgttgga attaatcaca 3862441 tatgaaacag cccatagatc ttagacgata gggggctatg cgtgaaaaca gaagttcaca 3862501 gcatagctcc tttttgtatg ggcgctttac caaagtaaag aaaaaggagt tgggcttatg 3862561 gtgactttag acggttcttc attgacaaca gccgacgtcg ctcgtgtgct gtttgatttt 3862621 gaggaggcag cggcttctga ggaaagtatg gagcgcgtga aaaaaagcag agcagcagtg 3862681 gaacggattg tacgcgacga aaagacaatc tacggcatca acaccggatt tggcaaattc 3862741 agcgatgtcc tgattcagaa agaagactcg gcggcgctgc agctgaattt aatcctttct 3862801 catgcctgcg gagtcggcga cccttttcct gagtgtgttt ccagggcaat gctgcttttg 3862861 cgcgccaatg cgctgttaaa aggcttttcc ggtgtacgcg ctgagctgat cgagcagttg 3862921 cttgcttttt taaataaacg cgtccatcct gtcatccctc agcaaggatc acttggcgca 3862981 agcggagatc tggcgccgct ttcccacttg gcgcttgcgc tgatcggaca aggagaagtc 3863041 ttttttgagg gggaaagaat gccggcaatg acaggcttga aaaaagcagg tattcaaccg 3863101 gtaacgctga catccaagga agggcttgcc ttgattaacg ggactcaggc catgactgca 3863161 atgggggtgg tcgcctacat cgaagctgag aaactagcct atcaaacaga acgaattgcc 3863221 agcttaacga ttgaggggtt gcagggaatt atcgatgcat ttgacgagga tattcactta 3863281 gcccgcggct atcaggagca gatcgatgtc gcagaacgaa ttcgctttta tctatctgac 3863341 agcggcctga caacctccca gggagaactg cgggtacagg atgcctattc attgcgctgt 3863401 attccgcaag tacacggtgc gacttggcag acactaggat atgtcaaaga aaaattagag 3863461 attgaaatga acgcagctac agacaatcca ctcattttca atgacggtga caaagtgatt 3863521 tccggcggaa actttcacgg acagccaatc gcctttgcca tggattttct gaaaatcgca 3863581 atatcagagc ttgcgaatat cgcagagcgt aggatcgaac gacttgtgaa tccgcagctg 3863641 aatgacctgc cgccgttcct gagccctcat cccggtctgc aatccggtgc aatgatcatg 3863701 cagtacgccg cggcctcact cgtttctgaa aataaaacac tggcccatcc tgcaagtgtg 3863761 gattccattc cgtcatccgc caaccaagag gaccatgtca gcatgggaac catcgccgct 3863821 cggcatgctt atcaggtgat cgcaaataca aggagagtca ttgcgatcga agccatttgc 3863881 gcattgcagg ctgttgaata cagaggcata gaacatgcag cgtcctatac gaaacagctt 3863941 tttcaagaaa tgagaaaagt cgtgccgtcc attcagcagg accgtgtttt ttcctatgac 3864001 attgaacgct tgactgactg gctgaagaaa gaatctttaa tacctgatca tcagaataaa 3864061 gaactaaggg ggatgaacat atgactgatg taaaaaaatc aatccgtgcc aacagaggaa 3864121 cagagcttga atgcttagga tgggagcaag aggcagtgct tcggatgctt cgaaacaacc 3864181 ttgatccaga agtcgccgag aagccggagg acctcatcgt atatggcggg attggcaaag 3864241 ccgcacggga ttgggacgct tttcacgcca ttgagcattc cttgaaaaca ttaaaaaatg 3864301 atgaaacatt gctcgtgcaa tccggaaagc ccgttggcat gttccgtaca cacccgcagg 3864361 cccctcgcgt gctcctagca aattctgttc ttgttccgaa gtgggcagac tgggagcatt 3864421 tccacgaact tgagaaaaaa gggttaatga tgtacggaca gatgacggct ggcagctgga 3864481 tttacattgg ctcacaaggc atattgcaag gaacctatga aaccttcgct gagctggcgc 3864541 gacagcactt cgggggcagc ttaaaaggaa cgttgacgct gacagcgggt ctcggcggaa 3864601 tgggaggcgc ccagccgctg tcagtcacga tgaatgaagg cgtcgtgatt gccgtcgagg 3864661 ttgacgagaa acgcatcgac aagcggatcg aaacaaaata ctgcgatcga aaaacagcat 3864721 cgattgagga agccttagct tgggctgaag aggcaaagct ggcaggaaaa cctttgtcca 3864781 ttgcacttct cggaaacgca gctgaggtgc atcacacact tttgaaccga ggcgtcaaaa 3864841 ttgatattgt gacagatcag acatctgccc atgacccttt aatcggttat gttcccgagg 3864901 gctattccct tgatgaagct gaccgtttgc gtcaagacac tccagagctt tacgtgcgcc 3864961 ttgcgaagca aagcatgaaa aaacatgtcg aagccatgct ggcctttcag caaaagggct 3865021 ctattgtatt tgactacggc aacaatatcc ggcaagtcgc aaaggatgaa gggctggaga 3865081 atgccttcga ttttccgggg tttgtccctg cctacatccg ccccttattc tgtgaaggaa 3865141 aagggccgtt ccgctgggcg gcgctttccg gagatccggc agatatttac cgtacggatg 3865201 cgttattaaa agagctgttc ccgacaaata aagcccttca ccgctggatt gatatggcac 3865261 aggaaaaagt caccttccaa ggcttgccgt cccgtatctg ctggcttgga tatggagaac 3865321 gaaaaaagat gggcctcgcc attaacgagc tggttagaac cggggagcta aaagcgcctg 3865381 tcgttattgg gagagatcat ttggactgcg ggtctgtcgc ctctccaaac cgggaaacag 3865441 aagcgatgaa ggatggaagt gacgctgtcg gtgattgggc tgtgctaaat gcgcttgtca 3865501 acacggcggc gggtgcaagc tgggtttcct tccaccatgg cggcggcgtc ggaatgggct 3865561 attcccttca tgccggcatg gttgcagtgg ccgatggaag tgagctggct gacgagcggc 3865621 tcgcgcgggt cttaacgagc gacccaggaa tgggcattat ccgtcatgcg gatgcgggtt 3865681 atgaacgtgc cgttgaagta gcgaaggaac aggacattat cgtgccgatg caaaaataaa 3865741 ggagtgatga catgccaaag caaattgata cgattctcat caacatcggt cagcttttga 3865801 cgatggaaag cagcggtccg cgggcaggca aaagcatgca ggatcttcat gtgatcgaag 3865861 acgctgttgt cggcatccat gaacagaaaa ttgtgttcgc cggacaaaaa ggggctgaag 3865921 ccggttacga ggcagacgaa atcattgact gttcgggacg ccttgtaacg cctggcctcg 3865981 ttgatccgca cacccatctt gtatttggcg gatctcgtga aaaggagatg aaccttaagc 3866041 ttcagggcat ttcatatttg gatattctgg cgcagggcgg cgggattctg tctacagtca 3866101 aggataccag ggcggcttca gaagaagagc tgctgcaaaa agcccatttt catctgcaaa 3866161 gaatgctgtc ctacggcaca accacagcag aagtgaaaag cggctacggc ttggaaaaag 3866221 agacagagct caaacagttg cgtgtcgcaa agaaactgca tgaaagccag cctgttgacc 3866281 ttgtttccac atttatggga gcccatgcga ttcctcccga atatcaaaac gatccagatg 3866341 attttctgga tcaaatgctt tcccttttgc cggaaatcaa agagcaggag ctcgccagct 3866401 ttgctgatat ttttacagaa acaggcgttt ttacagtcag ccaatcccgc cgttatttac 3866461 aaaaagcagc tgaggcaggc ttcggattaa aaatacacgc agatgaaatc gatccgcttg 3866521 gaggtgctga attagcaggt aagctaaagg ccgtctcagc cgaccatttg gtaggtacat 3866581 cggacgaagg cataaagaaa ttggctgagg caggaacgat cgccgtcctc ttgccgggca 3866641 cgacatttta tcttggcaaa agcacatacg ccagggcaag agctatgatt gatgaaggtg 3866701 tatgtgtcag cttggcaacg gattttaatc ctggcagctc gccgactgaa aatatccagc 3866761 tgattatgtc cattgccgcg cttcatctga aaatgactgc agaagaaata tggcacgcgg 3866821 tcacagtcaa tgccgcatat gccataggaa aaggagaaga agccggtcag ctcaaagctg 3866881 gccgctcagc tgatcttgtc atttggcaag ccccgaacta tatgtatatt ccgtatcact 3866941 acggggtcaa tcatgtacat caagtcatga aaaatggaac aattgttgtc aacagggagg 3867001 gagccattct tggataagta cccttttctc agagaggccg gatcttcgtt taaagaccgg 3867061 gatgtcacaa aaatgagcga cctgatcgca acatgggacg gccaggacat taagggaccg 3867121 gcgttgatag gtgtccccct atcaaaatcc tccatcagtc attcaggcgc ttcctttgca 3867181 cccggaacaa tacgccaggc tctgaaacat tcatcagcct attctgctga gcttggagag 3867241 cacgtcgtat cagagcttct atatgacctg ggggatatcg atattcatgt cactgatatc 3867301 gtaaagtcac atcatcacat tttccaaacc atgcacgctc tgctttcgga tcatccggat 3867361 tgggtgccgc tcatacttgg gggagataac tctatcagct actccacaat aaaagcgata 3867421 gcacaaacaa aaggaacgac agcggtgatt caatttgatg cccatcacga tgttcgcaat 3867481 acggaggacg gggggccgac aaacggcacc cccttccgcc gccttttgga tgaagagatc 3867541 attgaaggtc aacatttgat ccagctgggt atcagagaat tcagcaacag ccaggcctat 3867601 gaagcatatg caaaaaaaca taacgtgaac attcacacga tggacatgat ccgggaaaaa 3867661 ggactaatcc caacgataaa agagattttg cctgttgttc aagataaaac agatttcatt 3867721 tttatatctg ttgacatgga tgtcttagac cagtcccatg cacccggctg tccagcgatt 3867781 ggcccgggcg gcctctatac agacgaattg cttgaagcag tcaagtacat cgcacaacag 3867841 cccaatgttg ccgggattga aattgttgaa gtcgacccta ccctcgattt tcgagatatg 3867901 acaagcagag ctgcagctca tgttctgtta cacgcattaa aaggaatgaa actctcccca 3867961 ttcaagtgat cttctggcag gttgtatttt gggtataaga aactcatctg cctaaggaat 3868021 ggcagctaaa aggagggcga gacagtgaat cttcaggaga acagcagcca acagctaaaa 3868081 cgcacaatga aaagcaggca cctatttatg atctcattgg gaggcgtcat aggcacagga 3868141 cttttcctca gtacgggcta tacgctacat caagccggac ccggcggtac gatactcgct 3868201 tatgtaatcg gcgggttgat gatgtacctc gtcatgcaat gtctcggcga attgtcggtt 3868261 gccatgccgg tgaccggctc ttttcaaaaa tatgctacaa catttatcgg tccatctacc 3868321 ggttttatgg tcggcatcat gtactggatc aattgggtgg tgacggtagg ctctgagttt 3868381 accgcatccg gtattctcat gcagcgctgg ttccctgaca gcagtgtatg gatgtggagt 3868441 gcgatttttg cagcccttct ttttatatgc aacgcatttt cagttaagtt atttgcggaa 3868501 actgaatttt ggttttccag cgtaaagatt gtcaccatta ttttatttat cattttagga 3868561 ggagccgcca tgtttggcct gatctcttta aacggaacgg cggatgctcc tatgttgtca 3868621 aacttcacag atcatggcgg gttgtttcca aatggctttc tcgccgtttt tatcgcgatg 3868681 atatctgtga gcttcgcctt ttccggtaca gagttaatcg gcgttacagc aggagaatca 3868741 gcaaatcctc aaaaggatat accgcgatcc atccgtaatg tcgcatggag aaccgtgatt 3868801 tttttcattg gcgctgtctt catattatcc gggttgattt catggaagga cgcaggcgtg 3868861 attgaaagcc cgtttgtcgc cgtatttgcg gagatcggaa ttccttacgc tgctgatatt 3868921 atgaatttcg taatattaac agccttgctg tctgtcgcca actcaggctt atatgcttcg 3868981 acccgtatga tgtggtcttt agcaaatgaa aacatgatca gctcccgttt taagaaagtg 3869041 acatctaaag gcattccttt aaatgcctta atgatcagta tggctgtatc ttgtttatct 3869101 ctcgtttcca gtatcgtggc ccctggaact gtctatgtgg tgatggtcgc aattgctgga 3869161 tttgcaggag tcgtggtctg gatgagcatt gccttgtccc aactcttgtt tcgaaagaga 3869221 tttttgaaaa aaggggggga tgtaaaagat ctgacatttc gcacgccgct ttatcctctt 3869281 atgcctatag ccgctctctt attatgttct gcttcttgta tcggtcttgc ttttgatccc 3869341 aatcaaagaa tcgcactttt ctgcggagtt ccttgtatca tcctttgcta tctcatctac 3869401 catttcaaaa gaaatgttac aaaagcgaaa aaaatcagcc aagaggaata tccagccgat 3869461 cacatcctat aattaaaaaa gcacaccccg ctcagcatgg gatgtgcttt attttttatt 3869521 ctgtaattaa cgtatgaatc agcttcggcg ccttcgcttc cgcggcgatg cggatgttgt 3869581 catagacttt tgcgatgact tcatcgacgt tttctcggtt agcgtaaagc gttacgagcg 3869641 gttccccttt ttctactttg tcgccgacct ttttgcggag catgatgccg acggctaaat 3869701 cgatttcgtc ttcttttgtg gcgcggccgg cacctaacag catcgccgcg acgccgattt 3869761 cgtccgcgac gatttcagag acgacacccg cttctttggc aggcacatca atttgatatg 3869821 cggcttgcgg aagcttagac ggatcgtcaa caattgagct gtcgccgcct tggtttttca 3869881 ggaaatcctt gaatttctca agtgctttgc cgtttttcat gacttcttcc agcttcgctc 3869941 tcgcttcgtc caatgtatcg gcttttttcg caagcacaac catctggctg ccgagcgtta 3870001 agacaagctc atgaagatcc tcaggcccct cgcctttgag cgtgtcgatc gcttctttga 3870061 cttcaagcgc atttccgatc gcaaagccga gtggctggga catgtctgaa atgacagcca 3870121 ttgtttgacg gccgacgtta tttccgatgc gtaccatcgc tttggcaagt tcagctgcgt 3870181 cttcttctgt tttcatgaag gcgcccgctc ccgtttttac gtcaagcacg atggcgtccg 3870241 ccccggcagc gatttttttg ctcataatcg agcttgcaat gagcggaatg gaattgaccg 3870301 ttcccgttac atcacgaagc gcgtacagtt ttttatcagc cggcgttaaa ttgccgcttt 3870361 ggccgatgac cgcaaccttg tcgcggttca caagtttaat aaattcatcc ttcgtcagtt 3870421 ccacgtggaa gcccatgatt gcctctaact tatcaatcgt gccgcccgta tggccgaggc 3870481 cgcggccgga catcttagca accggcacat caagagccgc aacaagcgga gcgagaacga 3870541 gcgttgtcgt gtcgccgacg ccgccggtag agtgtttatc cactttaatt ccttcaatgg 3870601 cagaaagatc aatcgtttca ccggagttca ccatagccat cgtcaagtcc gcgcgttcac 3870661 ggtcactcat atcctggaag aaaatcgcca tagcaagcgc gcttgcctga taatcaggaa 3870721 tgcttccatc tgtatagccg ttcacaaaaa attgaatttc ttcagtggtg agttcttttc 3870781 cgttttgttt tttgatgatg atatctacca ttctcatgtt tggtcaccga tccttttcga 3870841 ttaagttcag taaatcaagc ccacaattgc tgctgataaa aagctgacaa gcgtagcacc 3870901 gtataataat ttcaagccga aacgagcgac gacatttcct tgcttttcat tcagtccttt 3870961 tacggcaccg gcaatgattc cgattgagga gaagttcgca aatgacacaa ggaataccga 3871021 tacgatcgct gttgtacggc cgctgaaatg gaaaccgttt tgcgtaagcg acgtcatggc 3871081 gacaaattca ttcgatacca tttttgttgc cataatgctt cccgcattaa cagcttcatt 3871141 ccatgggata ccgacaagaa aagcgaatgg agcaaacaca tatccaagaa tgccttggaa 3871201 cgaaataccg aatactgcat taaaaatgcc attgatcaat gcaataatcg cgacaaatcc 3871261 aatcagcatc gcagcgacga caaccgctac tttgaaaccg tcaagaatgt attctccgag 3871321 cacttcgaag aaggattgtt tttcttcttc ctcaacacga agcatatcct cttcttttgc 3871381 aacctcgtac ggattgataa tagaagcgat aatgaaaccg ccaaataagt tcaaaacaag 3871441 cgctgttaca acatattccg gtttcagcat tgtcatatac gcaccgacaa tcgacattga 3871501 tacagttgac atcgcagatg cgcaaagcgt gtacaagcgc tgctgattta aaagaccgag 3871561 ttctttcttc aaggagataa atacttctga ctgccctaaa atcgcagaag ccactgcgtt 3871621 atacgattcc aatcttccca taccgtttac cttgctgagg gcaaggccga tatatctaat 3871681 gataaacggg aggactttcc acttttgcag aatcccgatc agagcggaaa taaacacgat 3871741 tggcaagaga acattcataa agaatgtcgt ttggtccgca ttcaccaagc cgccaaacac 3871801 aaagttaatt ccctctgccg cgtattcaag caggtaaccg aatccttttg caaatcctcc 3871861 cacgaggaaa ttccctattc cggtattgag gagaatgtag ccaagaataa attgcaaaat 3871921 gagcataaca acaattgggc ggatcttaat tctttttttg ccgctgctcg cgatccacgc 3871981 gaggcctaaa aacacgatta aaccgataat cccaatcaaa tacttcatat gtgtttctcc 3872041 tttatttgta ttcgcttaca attactgttt cctcagaaaa cggaaagcag tctgccttcc 3872101 gtcagctctt aatagttgtc tccgcctgat gcattttctc cttttacgat agaaacgcct 3872161 gcgctggcgc caattcggct tgctccggcc tctaccattg tgtctacatc ttctttcgtt 3872221 ctgacgccgc cagatgcttt cacgccgata tcaggcccta ctgttttgcg cattaaggcg 3872281 atatcttcct tcgttgcgcc gcctgtagaa aagcctgttg atgtttttac gaaatccgct 3872341 cccgcagaca ccgctaaacg gcatgcacgt tctttttctt catcagtcag aaggcacgtt 3872401 tcgataatga ctttgacaag cgcttttccg gctacagctt ccactacacc gcggatatca 3872461 gcttccacca catcgtcttc cttgtctttt aaagcggcaa tattaatgac catatccact 3872521 tcagtggcgc cttttgaaat ggcgtctttt gtttcgaacg cttttgtttc agttgtattg 3872581 gcaccgagcg ggaagccgat gaccgtacaa acgtcgactc cagttccctt aagctctttt 3872641 gcagcaagct ccacccatgt cggattgaca catactgaag caaatttgta tgttttcgct 3872701 tcttcaatta gttttagaat gtccgctttt tgtgtatgcg gtttcaaagc tgtatgatca 3872761 attatgttgg ctaatgacat ccttcgcaca cttccttttt tgttaagata ttttttagca 3872821 taaccgactt ttgaacatat gtaaattggt aattgaaatt ttgttcaatg aaaggtttga 3872881 acgtgtcaca aatcattaac aagcgccctc gcggtatgct ggtcaatgat taaaacgttg 3872941 gcatattttc cggttaatgc tccgtgaatg gaagatactt ttctgcttcc gccggcaact 3873001 aaaatggagc gttccttcag tctaaggtct tgaagctcaa caccgatggt ccggtcattg 3873061 atggcgctgc tgcaaatatt ccctttcgca tcaaaaaagc gtgaacaaat atccccgacg 3873121 gcctgttttt tcagcagggc tttctcttct tcgttaaaat atccgagccg aaacaacagc 3873181 gcttcatcac ggacagtccc gaccgtaaag agagcgatat tcgcctgctt gcccatctca 3873241 atgatccgtt caatatgacg gtctttctcc accattcgct tcacatccgc attatcaaac 3873301 acgacgggaa gcgggagata gcgcggcatc gtttgaaaag cctctgcaaa cagctgaatc 3873361 gtttcagccg aatacgtgtt tacccgggaa tggctgatgc cgcctttcag ctggacgacc 3873421 tcgacgcctt ttacctgctt cggctgcatg ttttgcgcga tttgatacat ggtggttccc 3873481 cagctgacgc cgacaatgtc gccgtctttt accgtttcat gcatatattc tgcaccatag 3873541 cggcttaggt catgtgtaat tcctgcataa tcgggtgtcg gggaaaacac aacatgcgcc 3873601 tcaaggagcc cgtatttctc ttcaagtatg gaaccgagcg catccaaatc ctcaaaaggg 3873661 tccatgacgc gaatctggac ataccctttt tcctttgcat attgcagcag ccgggaaacg 3873721 gttggccttg aaatgttgag ctgctcagca atttgctgct gactgtagtc agactgatag 3873781 taaagccttg ccgcttctat gcttaattgc tgtttttccc gatccattct gcacctccct 3873841 gtggatcagt cctgataaaa ctgcttttga tttgctttta ttatacaggc tggcgccggc 3873901 tttcatccac ctgatttcta agaaactgaa aaacgctctg ggcgcggacc tgcccagagc 3873961 ttacttctcc caagtcatat gctgataaat gcctttcata atggcgtaca ttccatatag 3874021 gatcaggcct aatgccaata tagacagaat caatttgcca tgcggctgct gcgcgagttc 3874081 tgcgagcgcg ccgtcaaagc ctcttgtgtc gtcgggatca gcggtcatgg ctgtcttgat 3874141 gagaaaatag ccgatagccg agaaaataat ggcccgggcg atattgcctg cgcgtcctgt 3874201 gtttttcgtg atgcatatca tctgtttgtt catttttgat gtatcgaatt ctttcataaa 3874261 agcagcccga acgcctttca taaattgaac aatcgcaaat acgataaaac ccgcacccgt 3874321 aagccctgtg agccattggc cgaacggctg cgccaataca taagcggacc acgtctgttc 3874381 tgaagtgccg ccgtcccctt ggccaaacac aaatcgcaag gcattccaag cgatggatgt 3874441 gtaaacagcg gcactgaaaa agtttcctat tctccgcgac aggcctcgcc tgctgtttcc 3874501 gtgcccctcc gtgtccttga tcgcgcttaa caccatccag atcacatagc cgataaggcc 3874561 gatgcctata aaaaaaagca atagtgaccc atacggcatg cgtgatagcg tttggagagc 3874621 tccgctcgaa tctttggcgc ggcctgcccc ggcagccgtc ataaaagcca aaaccccaag 3874681 cagaataaaa acgccgccga atgcaaaata accaagcctc ccgaatcgtt tgatccaagg 3874741 cttggtttcc tgttttattt ttgacatgta ccggtctttc accgccatgt gtccaaccct 3874801 ctttcacaga aatctttact gtaacattcc cgattgaaca aagttgaaac agctcctgcc 3874861 tcagctatgg ctggctgaga tacgtttttg ctgtttagct gattgtgcag gtgtcatcca 3874921 agcagccgct gcggcagctg tgactccgcc tgctaatttc ccaatgatca tggccgccgc 3874981 catttctttt ttcattccag ctacaaaacc gagatggctg ccgagtacaa aggcgccgct 3875041 gaccgcaaac gcgacattga tgacctttcc tctcggcgtc atatccttta atgaagccag 3875101 cattgggata tgatgcgcca aagaggtcac taagcctgct gttgctgtct catctaaatg 3875161 aaggcatttc cccagagcct gaagcggttt tttaaaggtt tttgtaataa atgccgtcat 3875221 cgggaacgcc cctgccagag caatggcgat ggtccctgtc gtttgtatcc ctgtctcgac 3875281 attctccatt cccggaatca gcacaatgcc ggtcatcgtt tcaacagaaa cagctgcaag 3875341 cccgataatc gcaaccatac tgaccgcttt cccgaagaga tgaaacaact gaatcattct 3875401 gtcggtgtat cgccataacc caaaagcgat gacagcagat aacagactcg ggatcagaag 3875461 atttttacct atcatgccga tgtcaaagcc tgcgcataat ccgccgatta agcaaccgat 3875521 cggcactgtg cacagcccga ttaatatgcc tttcgcaaaa tacggatgat cctctttttc 3875581 gatgatgcca agagcgacgg gaatcgtgaa gacgattgcc ggccccatca ttgttcctaa 3875641 aaacacccat gaaaacagcc cggcctgcgg atctttcgcc atttctccag ccagcgcata 3875701 tcctcccata tcaatcgcca aaatggtgtt cgcaaaggaa gaaggatccg cgccaatcgc 3875761 tgtgtaaaac ggagcaacaa tgggaatcaa gattgctgcc agcacgggcg ccagcgatac 3875821 aattccgatc atggacagcg ccagcggccc catagcctta aagccgtccg caaaccgctc 3875881 gcctagcccc catctgtttc ccaaacaata atccgctgct ccccatagta aaaaggcagc 3875941 caaaatgaat acaaccgcgt cattcaccgt catggttttc tcctttttca aacgtatgat 3876001 tggttttatc atatcatctg aaatcaccga atagagttga tcttattcaa tatgagctaa 3876061 aaattctttt atatcggctt tttcaacggc tgttataatg cgtcgcgctt tttcttgcgg 3876121 gaccgttaat gtcaattttt ctattatgtc ttcttcagac agctcatttc ctggtgcccc 3876181 ttttgggcag tccacacgcg cttcgcaaat ccggccgtct gataaatagg cccggacaat 3876241 cgtgaaacgg ccttttggaa cggcatgagg agccggctga atagcattgt catatacgcg 3876301 ctgaattcgc cccattgtcg tttgaacccc gtttgggatc ggctggctgc tgaaatgttc 3876361 aacggtcagg ccgtgtccat gcaaagcaag agcaatcaca tattcaacgc tgaaacggcc 3876421 ttcctctcca gcttttggag atctttccgt caatgcagca tctccgcctg gcggaaatat 3876481 cacttcaata cgttcggtat tggcagcaga aatggtttct tcggagataa gctgtcgtac 3876541 cgcatctgca gcatggtgtg ccgcggaaca aaatggatag attttaaacc atagacccgg 3876601 ctgcacaatt ctccacggtg ccccccaatc gtttagcaaa gtgtgttgtg ctttctcaac 3876661 gtcaccgtac agactgaaga aaccagtttc tccatcaagt gccgtgcggg acccgccaaa 3876721 ttctgattgg gccagcttaa cggccagcaa gccagcctga gccgccaaac cggcgtgcag 3876781 cggtttcatt tctgttccaa attgcaccct catcccagca gattgcgtag ccgcaaaacc 3876841 aattgctttt tccaactctt cctgagtcag ctcctcagca taacctacgg cgcaggcagc 3876901 agcgatggca ccaagcgtac ctgtattatg ccagcccttc tcatagtggc ggctgccaat 3876961 tgattctccc agccgtgcca tcacttcaac accaacaaca taagcgccaa gaagccgctc 3877021 gtcatgtccg cgagcggcag aagcaataag ggccggtacg atgactgcac tggggtgtcc 3877081 tcttacatcg gagtggacat catcaaaatc caatgcatgg gcgataaatc cattgagcat 3877141 cgcggattgt aatggcgcgg cctttttgcc ctgtccgata acaggaacaa ggggccggcc 3877201 tccttcatcc tctatcagac ggaggagctt ttgaattcct ttatcttctc ttcctgcgaa 3877261 tgaagcggca gtaaaatcaa gtaatccctt ttttgcttcg tgaatcgcgt caactgaatg 3877321 ctcaggttgt gacgttctca cagcctctgc aagacctgct gtcagccctt gtttgctcat 3877381 ttgatggtct ccaatacaat aaccgccagc tccgcaaagt attgagaggc aaccgtaagg 3877441 gcttcttcat ccagtgtaaa ggccggatga tgccactcct ccgtcccgtt cgttcccatc 3877501 cagacaaaaa atcccggaat cttctcttga tacagagcga agtcttctcc gcccggagac 3877561 tgctcagcgt gaacggtttg atagccaagc cgtgccgcag cttcggatgc cgcattcaaa 3877621 aatgtgccgt cattctgaac ggaaggcaaa taaggaaacc acttgaattc tgcttgtgcc 3877681 ccatagcccg ctgcaattcc ttcagccact cgtctcatat gctcgggaac agcctgcctc 3877741 gcttcttttt gaaaggttcg aaccgtcccc tccatttcag cttggtctgg aattacgttc 3877801 cacgaggtgc ccgcctgtac tcttgtgata ctgacgactg cgttttgcag tgagctgata 3877861 ttgcggctga ccacagattg cagcccgctg atgatttgtc cggctgcagc gattggatca 3877921 atactgttat ttgggatgcc ggcgtgcccg cctttccctt tgatgacgat ctcaaatcgg 3877981 tcaacacttg ccatgagcgg accttccttt acaccaatgg tcccgacagg cagatccggc 3878041 ttattgtgca tgccgaaaat cgcagaaacg ccattaagta cgccagcttc tagaaccttt 3878101 cttgctcctg cggcaatttc ttcggccggc tgaaagataa agcggactgt acctttcagc 3878161 tcggcccttc tttgattcag caacatcgct gtgccaataa tagaagcagt atgaaaatcg 3878221 tgtccgcacg catgcattgt gccatcaacc ttagatgcaa atggaagatt cgtctgttct 3878281 tggatcggga gcgcgtcaat gtccgctcgt attgctatca cggggccgtc ttcccgtcct 3878341 ttgatttctg caatcacacc agtcttcaat tgagggacat caagtatttc gatttgctcc 3878401 tcctcaagcc aacggcggat ttttttcgtc gtttcaacct cttgaaatga cagttcagga 3878461 tgttcatgaa gatcacgccg catattgatt aaacgggtat gaaacgcttt gtcggccatt 3878521 gttcttctcc ccttcttata taagctctgc aggctctccc acctgcttga taaatcgttt 3878581 cgtccgttcg tttttcggat ggtcaaacag ttcctctggc gttccctgct cgataatatg 3878641 gccgtctgcc ataaaaatca cttgatcagc aacctctttt gcaaacgcca tttcgtgtgt 3878701 aacaatgatc atcgttgttt gtttttccgc aatggacttg atgacctgaa gcacccctgt 3878761 gacgagctca gggtcaagcg ctgacgttgg ttcatccagc aaaatcgcat gcggattgac 3878821 cgcaagcgcc cgcgcaatgc cgattcgctg ctgctggccg ccggacattg tgattggata 3878881 gctgtcagcc ttatgctcca gaccgacttg tttcagaatc tccattccaa tacgtttcgc 3878941 ttcgtcgcgt ggtttatgtt gagccacgat taaagcttct gtaatgtttt gcagagccgt 3879001 tttattttta aacagattgt agttttgaaa gaccatggcc gtttgctggc gaagccgatg 3879061 tgcttccttg cgtgtaaact tttccgcatt cagtttggct tctccgattt caataaggcc 3879121 ttgatccgga cgctctaata gatttaagca ccggagaagc gttgattttc cggaaccgga 3879181 cggaccgatg attgccacca cttctccgcg tttcacttct agatcgattc cgtcgagcac 3879241 gacgagatct ttaaacgctt tgcgaatatt ttttactgtt atcaactgat ttcacctcta 3879301 agtccggtat ggcttgctca tggcacgttc aaacaagtcc tgcaaaatgc tgtagataat 3879361 ggtaagaacc caatagacga tcgcaaccgc caaatacgtc tcaaaatatt tgaggtttcc 3879421 tgaagcgtac atcttccctt gggcgaacat ctccatgacc cctaatgtaa aggccagtga 3879481 cgtttctttc aggagcccga taaatgtatt gcccgttgcc ggaatcgcat ttcggatcgc 3879541 ttgcggcaaa ataatccgtc tgtatgcctg aaattttgtc ataccgacag acaggcacgc 3879601 ctccagctgc ccgtcatcaa cagaattgag ggcggcccgg aagatttctg ccaaataagc 3879661 tgcgtttttt aagcttaacc cgatgatggc agctgtgaga gctgtcattt tgctcatctc 3879721 tggaaatagc tgcggcagcc cgtaatagat taagaacagc tgtacaagtg tcggcacgcc 3879781 tcggaaaaag gatatataca gctttgacag ctgatgaagc actggaattt tgttttttgt 3879841 aatgagtgcg agaataagtc ctccgataat ggcaaaaatc atagctgcta ttgccataaa 3879901 caaggtgatc ggaagggcct gaattaaagt cgggaacgct gatatcatga attcccaatc 3879961 aatcgtgttc attctggtga gtcaccgccg tttcttaatg cttctgttct actgtgatat 3880021 cttcattaaa gtatttttca gagagttttt tcagtgttcc gtctttacgc aattcatcta 3880081 gggccttatt gacttttttg cggagcttgt cgtgcgcatc gtccttggca aatgggaatg 3880141 caacctgttc gtaaacaatc ggatctcctg caagctttaa tggcaaaccg gtcttcttga 3880201 tttgcgcgat caatacagtt cggctgttga cataagcgtc tacacggccg tacgcaacat 3880261 ccttcagcgt accctcttgt gtttcgtacg ttttgatatt gattttttta tcaggatctt 3880321 tgctttcaag gtttttcgcg tggtttgaac cgagaacggc tgcgactgtc ttgcctttta 3880381 aatcgtctac tgatttgatg tctgtattgt cttttttgac gacaatctgt gttcccgcat 3880441 aagcgtatgg tttcgtaaag ttatacgttt ccttacgttc gtctgtcaca gctacctggt 3880501 tggaaatggt gtcaagcttg cctgtttgaa gctctcccat cagcccgctg aattcaagca 3880561 gcttccagtc cagtttcatg tcaattttct tagcgactgc ttccatcact tccacgtcaa 3880621 agcctgtcag ctttccgttt tctttataag caaatgggta actttgtcct gtcgcaccga 3880681 catgaagcac attgtcatcc tctttactgc tgctgtttcc attgccgcaa gctgagagca 3880741 ccgctaataa tgcagcaacg accagcactg tccatttttt catcttcatt tgattttccc 3880801 gccttttcta tttttataga tcatgtcgca attgtttttt catatagact gtgatatgcc 3880861 cttttccaag gtcttgttca cctgagcgga catatccttt tcgttcgtac atctcaatca 3880921 gccacggatg cttatccgct gttccgagtg agacaaacgg aacctttaac gtatcgcgaa 3880981 ggattgtttc ctccagccat tgaagcagct ttgttccgat tcctttttta ccggtgtcgg 3881041 ggtccacagc aaaccaccag atatgcggaa cgccatacgg tcccggctgt tttccccaag 3881101 gcattctcaa ggtgatggtc gcgatgatcc gcccgtcttc ttccatgacg tagcaagcat 3881161 tttcccgaat atttttcagc accaaatcca aatccgcatg agcagcagca aaacgaatgc 3881221 cgagctttcg aatcggttca taagcccgca atgtcagctc gagaagctgt tcggcatcac 3881281 gttcaactgc aaggcggtat cgtggcttca tctagcgttc ctccttactt tgcatagcgg 3881341 tttaccggct tttccaaacc gaagtgctct cgtaatgttg tgccttcata ttcttttctg 3881401 aacacgccgc gctcctgtaa aatcggaacc acttgatcaa caaacacttc aattccttct 3881461 ggaagaagcg gaggcatgat gttaaacccg tcacacgctt tcgtatccac ccattcctgc 3881521 atcttgtcgg cgagctgctc cggcgtgccg acgaagatat ggtggcctct ggagcctgca 3881581 acgtatttgt aaagctctcg tatcgtcata ttgtcacgtt cagccatctc ctgaacaagc 3881641 ttgaagcggc tcttcaccgc attggaagct tcggcgtcaa gcttcggcag cggcccatca 3881701 agcggatatg ccgacaaatc aattccgcct aagtaatttt ggagaatttg cagaccgaca 3881761 gatgggataa tcagatcttg gagctccttg tatttggctt gcgctgcttc ttctgtatcg 3881821 gcaatgattg ggaaaatacc cggcataatg gcaatttttt ctggatcacg tccgaattcc 3881881 gcagcctgtt ctttaatgga ttgataaaat tcttgagctg attccaggtg gttttgtgct 3881941 gtgaagatca cttcggctgt tttggcagcc agcgcttttc cgtctcctga tgatcctgcc 3882001 tggataatga ccggctggcc ctgcggggtt cttgaaacgt ttagaggtcc gcgaaccgag 3882061 aaatattctc ctttgtggtt cagctcatgc attttttctt tgtcaaagaa ttcacccgtt 3882121 tctttattac ggataaaggc gtcctcttcc catgaatccc aaagcccctt tacaatctcg 3882181 acaaattcct ctgcccgctg atagcgcaaa tggtgttcaa ggtgcttttc accgctgaaa 3882241 ttcagcgctg ttgattcaat agatgaagtg acgacgttcc atccggcacg gccattggac 3882301 agatgatcca atgacgcaaa ctgtctggca atatggaatg gctcgctgta tgtagtggag 3882361 gctgttgctg tcagtccgat ttttgatgtg acctgcgcca aagcagagag cagggtgaat 3882421 ggctcaaacc ttgttaatac atttggatgt gatttgctgt caattgaaag gctgtccgct 3882481 aaaaacagca tatccagctt gcctcgctcc gctgttttcg caagctcttt aaaataatcc 3882541 aaattcatgc tcgcatctga cggcgcgtcc gggtgccgcc aagacgcaac atgatggcct 3882601 gtacctgcta aaaatacccc taatttgatt tgtttctttt tgcttgtcat ggcgatactc 3882661 cttttatcat gtttttaggc tgaataatcc gaaaaataaa ctcctatatt cctagtcgtt 3882721 taatatgaat aaatcaaaat gtacctttgt cttggacgtt tgtcaatgag ttaagattaa 3882781 ttttttctat tcaagcgaaa agacccttgc gtgaccatga gggaacggca ttgattcatt 3882841 caactagtgc aacctctata tcggcaagaa aactgagtct aatgaagcaa agactcagtt 3882901 ttcttccaat aatttcatat aagatttcgc catttccttt gccttttctt cgcttttgca 3882961 aaccgcctat ccattcagac gccgtaacga ttgtataaaa aaacagctga ctccagatat 3883021 tcaaaccgga atcagctgat tgatgtgaat taattaagct catgaatact ctcttctgct 3883081 ttagcggaaa acactttagg ctccaaacag tcaaggtctt catgaaataa atttactttt 3883141 tggatttgcc gattgtcata gtggtggaaa tagtagtttc cagtttcgtt gcacatcacg 3883201 gaagtatatt gcgtataatg aatttcgtct tcttccgtta tcactgcgcc ctttggtatc 3883261 gtcatatttg ccaaaatttg aaaagcggct gttacacctt tcgtttcatc ggccgccggc 3883321 tctagatgtt ctttcaaata aacagctctg acaaaccggg aaggcggtgt ataatccccc 3883381 ggcagaccaa cagttcctaa gccttggcca aaagcagaaa gggctaatcc gcccatctct 3883441 ttgctctcta attgcttcgg tctgattcct gtatattgct gcagattggt tacatgccat 3883501 ataaagtcgg ggctgttcgt catgacacca ggttgattat catagacttt gaggccgtct 3883561 gctcttggtt ctatcgtcag gtttcggccc gtccggtctg acaatatcca gtgaagcggt 3883621 aaaactgtat ccaatagatc taattttttc tctacaatcg ttaaagatcg aatcttttct 3883681 tttacgtctt ccaaagactg acagactgac agcacccatg tcacaaactc atgcgggaca 3883741 atgtgaacgg tatcttcccg tatcgttttt tcgtactccg catagcccgg aaaataaagc 3883801 gccgcacaag ataaaccgct ttcattaatg ccgtcggcaa ataatatatt tccaagtttt 3883861 ctccccatac cgataaacgc gtactgtgtc tgatgggccc ttccgtcagc ttcactgttc 3883921 cagctgtaac ggcgcggata gagaatcacc tctgtcccca gctgaaatgc aaaatccatt 3883981 gttcttgcta atacatgttt acggtcagca gtttccaatg taagacttgt gcacatttga 3884041 tcagtcccct tttcaattca gattaatatc atacatattg tgaacgaatt ggttttatca 3884101 gcataacgaa agtcaaatcg attcgtcaaa gaattgacat tacatcaaat aaaacgaaaa 3884161 aatccagcct ttagaaggct ggatttttta ttatttagcc aaaacaagct cgtgaatcgc 3884221 atgtgcaacg ccatgttcat tattggagcg tgtttgaaag tttgctgctt ccaatacttc 3884281 tgggatggcg tttgccatgg caaccccgca gcccgcccat tcgatcattg tcaggtcgtt 3884341 cccgttgtcg cctatgcaca tgacttccgc ctgttcaatt ccaagcagct gagccagctg 3884401 gcgtacagca tttcctttgc tggcttccga gtgcagaatt tcataaaaga aaggcgcgct 3884461 tctgaccatt gtatattttt ctctcacgtc ttttggaatc gatgtaatga cgcggcttaa 3884521 gttctccggt ttatcaataa acatcacttt cgggatgagg atatcttttg gcacctcgtc 3884581 aatcttgcgg aaatgaagcg gcacctgtgt cacataggat tcgtatacgg taaattcgct 3884641 aatatcccgg ttaggcgtat acaaattaga tgagtcaaag aaatgcatcg gcgtcttcag 3884701 ctctaagctc aggtcatata atgaagtcaa atcatcataa ccgagagaca gctctgagac 3884761 cacttcattt gtatgcgtat tttgaacaag tgctccatta tacgcaataa catagtcgcc 3884821 ttcttcaatt aaattcagtt catctaaata tctctgcaca cccccgatag gccggccggt 3884881 gcaaagcaca attttgacac cttccgcttt tgccgcgtga agggcgtcgc ggacctcctc 3884941 tgttacttca tgatgatcat ttaaaagtgt tccatccata tcaattgcaa ttagtttgta 3885001 catcctgcat ctccttcatg tcgttttcag gctatagtcc catcatatcg ttttttcttt 3885061 ttgatattca accggaagag atggttttct ccggattctg tttagacgcc gcccttgtct 3885121 tcggatacgc aagcgcggtt tccgctttct ttctgccttg acgccgtttt ctgctttttt 3885181 ctgtttcatc agcagaaagc cggcagctag aaaaggaatg ccggttatat tcaagatggc 3885241 aagcttcaca cccgccgcga tgaaaaagaa cccccatgaa gatgatggat tccgtctgat 3885301 catgacgtaa gccgccattt ccagaacgat caggatggca tgaagcacta tgccataaat 3885361 cagcaataca agggcaaaaa acaaaacata attcacgatt gcccctgagt acatcatagc 3885421 gcgcatcatt tgtataaacg ataaggactg catggagccg ctgatgacat tagggttata 3885481 gatcgtatag tcactaaata aatgtttgac tttgagaaaa gcccataata taaatatcca 3885541 ttgaatgata tgtaaaacaa gccccgctgc caccagtctt tcagcttttt gatttctcat 3885601 ctttctcctc cctgccggtc tttgattcga ttcttgtcat cgtttttctc tgtccatttt 3885661 gctcccatat caatgtcccg ttttctcctc ttttcagcgt gcttttgagc ggataataag 3885721 ggccgaggta ctgaatctcg atagacccgt cagtgctttg ggaaatcacc ttgtatgcca 3885781 taaaaggcag ctgtacctct cctcttcctt ccatcacttc cgtttccaca acctcgtctt 3885841 cggtaaatgt gactgttgct gatttcacac cgtccgttgg cccgggggca cgcccctcat 3885901 cccacgttcc gtaataaaac ggcgtctctt ctttttgctg ctggcagccc gataccatga 3885961 tgcatacagc aattaaaaac aaaatgccat atttgtttct caaggggatc accattcttt 3886021 cctccttttt tgggcgaatg ccgtgccact gtgccaatga ctacataagt tataaggaat 3886081 tcacccacaa ggagactgat cacatgaacc cttatcaata ttacagccct cagctgcctc 3886141 agcaggaacc ttactatagc cactatgagt acaatcctta tccgcagcag gatgtatacg 3886201 atccatacca aatggacaga cagccggcat tggaaagaag aatcgcagca cttgaacggc 3886261 aaaatgaaca gcagtcaaga gaattaaccc gtctgacaaa cgaagaccgc cgtcaaaatc 3886321 gggaaattgc acggattgcc gaacaggtca atcagttaag ccaggctgtt gaacgccata 3886381 cacgccgcct aaatcggctc aatcagcgcc tccgtacagt agaaaaccgg ctgaatatcc 3886441 catttactgc aggggaaggc ggtttctgag cgaaacaaag aaaaaaagcg gaatacgatt 3886501 ctcccatctc agggtttcgt tttccgcatt tcttatatgt taaaacggaa catttacata 3886561 aaaagggttt gtacccagta tacaatcttt accgttttca ttcaaagata gaggggctga 3886621 ggaaaataat tgtagttcct ctttgacgga atttcttttc attcaagttg catgataata 3886681 ccgactcacg tcaatcgata catggaggga tcattcatgc ataatacaca acacggcttg 3886741 cagcagctga accaatgccg ccaaactgct cagcagctca ttcagcaaac acagcaaagc 3886801 agccagcaat atcgccaaat gcttcatcag gaacagcaaa acatccaaat gctgcagcag 3886861 attctaaacc acgaacaaca agctgcacat accattcagc aagcactgca cgggcatgac 3886921 atggcgattc aaaagtgcca gcaggttgtc aacatgtgca accaaatgca acaggaactt 3886981 actggacaat ccagcgtcat gaatacgaat gtgtctacac ttccattcgg ccaaaacacg 3887041 acatttcagc agcaatccta ccagcagtaa catataaaaa gctcaacaca atgcgagtgt 3887101 tgagcttttt ttcttactgt tctttgcgaa tatgtatatc ctgaatagac tgtttcggtg 3887161 catgaaatct gctctcggct tcacttcttg cctcggcaaa agcccgcgcc tccacatgat 3887221 ctttgtagac atccagctga atcaaataca gcgggcgcac tttaaatcca tgaataatgg 3887281 ttaccgccca taacgggacc acaataaaaa caccgggcag atcgggcaaa acaaaaccaa 3887341 acgcaaaaat gaaaaaataa atgatgccgt acatgatcca ctttctattt ctaaccttga 3887401 tgccaataaa taaaaaggca aaaaaactgg taatggcaaa aggcatgaaa ataaacagca 3887461 tccaccagct atgcagccat tcccaagcgg cacctctttt tgtaattccc atatttttct 3887521 cctcctattt acctataata atcgattagg cacaccgcgt cacccataaa cgggaaaaac 3887581 tttctccctt aaaaatagtg atagacggag aacaggtttc ttgctatatt attaattgat 3887641 aatgataatc attactaatc tattgagata catagtggga gggttcttga tgaaaaagaa 3887701 catattgctc gtgggcatgc ttgtgctgct tctcatgttt gtcagcgctt gcagcggcac 3887761 ggcttctaaa gggagctcaa gcgattctgc ttccgaaaaa acagaaatga gaacatacaa 3887821 atcaccaaaa gggaacgtca acattcctgc acatccgaaa cgcatcgtca ctgattttta 3887881 tgccggtgaa ttgctgtctg tcggggccaa tgtggtcggc tcaggctcat ggtcatttga 3887941 taatccgttt ttaaaatcaa agctgaaaaa tgtgaaggat gttggtgatc caataagcgt 3888001 tgaaaaagtg atggagcttc agcctgactt aattgttgtc atgaatgaag agaatgttga 3888061 taaattaaag aaaatcgctc cgactgttgt cataccttat aacacagcga aaaacgtaga 3888121 agacacagtc agcatgttcg gagatatcgc cggagcgaaa gaccaagcaa aatcctttat 3888181 ggctgacttt aacaaaaaag cggaagcagc taagaagaaa attgccggcg tcatcgacaa 3888241 agatgcaacc ttcggcattt atgaaaacac agacaagggc gaattctggg tgttcaatga 3888301 caatggcgga cgcggcggcc aagctgtata caatgcactt gggttaaaag cgcctgaaaa 3888361 aattgagcaa gatgtcatca aaaaaggaga gatgaaacag ctctctcaag aggttattcc 3888421 tgagtatgcc gcagattata tgttcattac ggattacaac ccgaaaggcg aaagcaaaac 3888481 actcgacaag ctggagaatt cctccatttg gaaaaatctt gacgctgtta aacataatcg 3888541 cgtgtttatc aatgactttg actcgttcta cccgtacgac ccgatttctg tcagcaaaca 3888601 ggtggatatc atcaccgaca tgctgatcaa acgggccgaa gaaaataaaa aataaaaaaa 3888661 cggcacagtc atgacgctgt gccgtttttt atgattcact ttaattttga ctgtacggag 3888721 tccggcatat cttcaaactt gacttcttcc caagtctcga catactttcc tttcgccttc 3888781 accttcaaat acgcgttctt ccgaagctct ttgccggcga aaaaggtcac ttcttctttt 3888841 ttcccggatg cattatatcc gtctaatgta tattcagtac cgcccggact aagatgtctg 3888901 ccatctcgat caatctgaac atagacatct tgctggtgaa taaacggatt aaatctgtct 3888961 gtaacatcgt tatgaaaaaa gagaagcccg catattacgg cagcagccgc caagacggcc 3889021 aggattgcca ttgctttttt catctttgca ctccccttac ttgttcattt ttttcaaata 3889081 gcttgaccgc accgcgagga agaatagaag ctgaaaaatg aaaaaccctc cgatggtgag 3889141 actgagcggc cccgctacat cggaatatcc ttccacagcc aatgttctca aggcaaacag 3889201 tgtatgcatg acggcaatga caaatggaaa gaagaaaaga atcgccaatt gtattgtcac 3889261 gctttgcgcc atttctcgct cactcaggcc gattttggcc agtgaacggt agcgctcccg 3889321 gtcttcatct aaatcagtga acagcctgaa atataagaaa cttgctgccg cgacaaagaa 3889381 tacaattgcg ataaacaggc cgataaatag actcaggctc ggcagctgca ccgtatcata 3889441 gtaagtcccc gcttttgaag caaaatcaga atgcacgtcg atataattgc cgtaaatctc 3889501 attttgcaag gattggctga tctcaagact gtctttccaa tgatcatagc tgtagccgta 3889561 taatgacgct ttatcaccga gtgatttcag ctgatcaaag gtttgatcat tcaccgcgat 3889621 gatagcattc aatgagatca gcggtttttt gacttctttt accgacagtt tttgatcaga 3889681 cagctcccct ttttggttca gcagcttcag ctgatccggc gcttcgtttt tgaaattgcg 3889741 gtcatacgtt cccgggaaat agacagcctc gtcttctttc aggccgttca ctttgacatg 3889801 gaagtatttt gccgcatccg attcactgat catgtaaaca gggggaacag tttctccttc 3889861 ctgatagcga acataggaaa catctatttt gtctttcgta tacgtaaaac cgtgtgtttt 3889921 cagttcatgg tcaatatctt tcaaatgagt ctgttctttt ggattgttgc tgtaagataa 3889981 atactccatt tcataagcgg actcttccgc tccgacggtc gatttgtaca ttgcgagcac 3890041 gcctgtcgca gtaaacgcaa ccgcggaaat aatgctgaca ataaagaaca ggcgggcgtt 3890101 gtcttttaga cgatagacaa ggtcagaaac ccaaatgatg tttttcccgc gcagataaaa 3890161 ggttttccac ttcttcagcg cgcgcagaat ccatatgctg ctttggctga aaaagaaata 3890221 tgttccgata acggtgagca gtaaaatgat aaacggttcg gccccgtgga cattgccttt 3890281 aagaaccatg ccgtacccgc cgcacagaca ggcgatgccg aataaggaca gaagcacgga 3890341 cggcttaggc tccggtttaa ccttgccagt gccctttatt aatttgataa ccgtatttga 3890401 tctgacaaaa aggatcgtaa actgcgataa aaagaaaaat aagagcagaa atccgcaggc 3890461 cgtaataccg agcgctttcc aaggcatata caaaggcagc gcgtccattt ctaaaatata 3890521 agcgccgacc gtaaagaacg tctttgaaaa aatgaatcct ccgataatac cggctgcaat 3890581 tgacatgacg ccgatgatca tattttccgc agtaatgagc tttctcagct gccccggcgt 3890641 gatgccctgc atgagcagaa tgccgaattc tttatttctc gatttcaaaa atgcattaac 3890701 cgaatacaga acaaataaga aagaaaaaac aaagatcatc cattccgcgg cggttaagcc 3890761 ttttttggcg atgttattca ggtagccttc ctttaatgcc ggatgaaaca ggaacatcgc 3890821 aaaggtaaag aaaatcaaaa cggaaaaggc gctgcttaaa aagaatgcaa gataggccct 3890881 tttgtttctc gtgacgtttt tataagcgaa ctgaagaaag gtcatttgcg tttcccccca 3890941 gcatagacag cacatcgaga atttgttcat aaaatacttg gcggttttcc ccgcggtaaa 3891001 tctcattaaa cagttcgccg tcttttataa agatgacgcg gcggcagtag cttgccgaaa 3891061 ccggatcgtg ggtcaccatc aaagccgtga catgatcatc ccgattcagg ctctgcaacg 3891121 tttccatgac gtcttttgtc gctttggaat caaggtttcc agttggttca tcggccagaa 3891181 tgagtgacgg cttatgaatg accgctcttg cgatggcggc ccgctggcgc tggcctccgg 3891241 atacttcaaa cgtccgcttg ttaagcaggt tttcgatacc gagctttgcc gcgatgccgt 3891301 gcagtttttc ttccattaca gacggcgctt ctttttcaag cgttaacggc agcatgatat 3891361 tttcaccgat cgtcagcgta tccagaaggt tgaaatcctg aaacacaaat ccgagctgct 3891421 tgcggcggaa atgagcgagc tttgtccgct tcaggcgatg cgggttttct ccgttaatca 3891481 ggatatcgcc tgaatctgga cggtcaatcg ttgaaatgat attcaaaagc gttgtttttc 3891541 cggacccgga cggccccatc accgccgtga actcgccttc ttctattgaa aatgaaattt 3891601 gctttaaggc ctgataggac acttgtcctt tataggtttt atttatatgt ttgacttcaa 3891661 gcatattcgc catgaaaatc ctccttatgg ttttattctt gttgatctgg gctgctttca 3891721 tgtagtgccg ggacgttcaa cataaaaatc cccttgacat aaatccatgt tatcaagggg 3891781 aaacaaagcg ggctatgttg ttttcttaac gcagccttac atttttgtaa gaaatgaaaa 3891841 tcgaactgat gtcccttcac cgggagacga gctgatgtcc accgtatgat tgagcttatc 3891901 tgtaatttct ttgacgagat ggaggccgat tcccgtagat tcttggaaac gccgcccgtt 3891961 ttcacccgtg taataagggt caaacacccg cttgatgtct tgtgagggaa tcccgacacc 3892021 gtaatctttg acttcaagca ccgtcctgtc ttcatcgcag aagacattca gctcaagtct 3892081 gtcactcttg cccgctgaat acttgaccgc atttgtgacc acttggccaa tcgcaaattt 3892141 gagccatttg gcatcggtgt aaatctgatg atcatcgcaa acgttcattt tcggataaac 3892201 gcgatattga ataaaaaatc gtttatagct ttgaataact gattggagaa gctcggacag 3892261 ggaaaccgct tcgattttaa aatcccgttc aaacaggtcg agccttgaag aataaagaag 3892321 cgtctccagc ccgaattcaa tctgccggac ttcttttttg atttgttcaa aaacgggctc 3892381 atcctcttct tgaatgatta aattaatgac cgacagcggc gtctttactt ggtgcaccca 3892441 ttgattcata tacgtcaccc gcgcgtcaag cttggcttcg gtctcatgga gcttctggtg 3892501 ctgcagccgg atcagctcca tctgcttttc atacagctct gaacagaaca ctgaagaacc 3892561 gagatacggg atatccgtcc cttcctgccc cgagctgagc caatgataca cgccgcggtc 3892621 tttgtaccag cgataggcaa gatagcccgc caaaataaga agctgcacgc ccaatatgta 3892681 aaacaagtga gaaaaagaat gaagacccgc aaaccagtaa taaaagaaga caaacagccc 3892741 ttgaaggaga aaaagcagaa tcagcactgc atgagaccgg agaaacagct tcatgactgc 3892801 gccctcagct ggtagccttc gccccgcacc gcttcaatag aaacaggcgc attcagctcc 3892861 cgcagttttt ttctgagccg cgtgatatac acgttaagtg tattatcatc gatgaatatg 3892921 tcggtgtccc acgtcttttc catgagacgg tcccgactcg tcaccttttc tccccgctca 3892981 agcagcactt ccaaaagctt gctttctttt ttagaaagct cacttttttc atcctgaaaa 3893041 cgcagttcaa accgttccac aaagagctga acgccggcat attcaaccac tttctctccc 3893101 tgctttgcgg cgtactcccc gtacgccctc cggatctggc ttttgatttt cgcaagcaca 3893161 atatcataag aaaacggttt ttcgatataa tcgtctcccc cattttcaat cgccatcacc 3893221 tgatccattt ccccgcttct ggcagaaata aagatgatcg ggcttgtgga gtgctggcgg 3893281 atctgccggc accaataata tccgtcatat gccggcaaat tgatatcaag cagcaccaca 3893341 tcgggctttt cccgcaaaaa gacatcaaga acagctgtaa aatccgcggc gaccactgtt 3893401 tgatatccgt atttttcaag gtaattctgc aatagtccgc gaatgtcttc actgtcttcc 3893461 acaatcatga ttttattcaa actgaaccac tcccgtttct tacactgctg ccatcatcat 3893521 aatcgttttg ggcgtatgga cgcaacaccg cacaaaaaaa ccgccatctc ggcggtttct 3893581 ggtctcttta gccgacctgc tgcttagctg ctttaccggc tgatccgaac tctctcattt 3893641 tgcttcgcac tgtctcttcc acggcttcaa tgccgggtgt caaatagccg cgcggttcgt 3893701 acagatcgct gttttcctga aacatgcggc gtgtttcgtc tgtccacgct accatacatt 3893761 ccgtattgat attgatcttc gcgtggccga gcgtgatggc ttttttgatc tgatcctgcg 3893821 gaatcccgga tgccccgtga agaacgaggg gaatatcagt catgcgggag atagcctcca 3893881 tttccttaaa tccgagattc ggctcaccct gatatttgcc gtgtacagag ccgagggcgg 3893941 cggccagcgc gtcgatattg gtttctttaa cgatccgctc acattccgtg atatccgcat 3894001 agcggacccc gccgaccagt ccgtcttcca ttccgccgac cgtgccgact tcggcttcta 3894061 ctgacacgcc gtgttttgcg gcataatcgg tgacttcttt tgtcatcgcg atattctcgt 3894121 caatcggctg atgggagccg tcaatcatca ctgagctgaa tccggcatca atggcctgtc 3894181 tgcagcgttc cgcactgctg ccgtgatcga gatgaagcac gaccggaacg gtaatcgcca 3894241 tgtcctctat taacgcgccg accatggcgg caatcgtttt aaatccgcct aaatagtcga 3894301 ccaggcgatc ggaagccgcg gcgatgaccg gtgattgctc cttttgcgcc gcctgcaaaa 3894361 tcgccttcgt ccattgcagg ccgttgatat taaactggcc aattgcatat tgctcccgct 3894421 ttgcatcttc aagaagctct ttcatcgata caaaagccat attcacccct cctttatcca 3894481 ttacatgctg aagtattttg atacgacatc cactgttgtt tttttcgctg tttgaatggc 3894541 ttcctcagca gtcagcttat agtattcagg ccggaagagc tcaaccgaaa caacatcaga 3894601 gaagccgatt tccttcagtg ctgataagtg ggcatctaag tcaattgccc cttgtcccgg 3894661 ccatacacga tcctcatctg ttaaaaagcc gattgggaaa tcttctgtat catcaatatg 3894721 atagatgaag attttctttc cgtccgcctg ctttaagctc tcaatatttg aacccattgc 3894781 atggaagtga aaactgtcaa ggacaagccc gacattgtca cggttaactg tgtttacaat 3894841 ctcatacgcc tgttcaaacg tattgaccgt acattgcgga tggccgacaa actcaagcgc 3894901 gatttttacg ccgtacggct ccgcgatatc tgacagctca gtcagcacgt ctacactgct 3894961 ctttttgatc tcttctttta caatcttctg ctctgtcaca agcggaacgg ccaccacata 3895021 tttcacaccg agggttttgc atgtttccat catgccttta aattcagtga tgatctcgtt 3895081 gtgacccttt tcatcacggt tgttgaagaa aacgagtgcg tttaaggcaa gcggtttgat 3895141 gtggtgggtt tgaaaatatt ccgcaaggtc atccaatgaa tgatctttta agtactccgg 3895201 cagcttatcc atagtacgga tttcaatata atcatagcca tgcttttcgc atagttctaa 3895261 atccagttta aggtttgagt tttccaatgt tgtcgcttca ttaaaacaaa gtttcatgcc 3895321 agactccccc atctgcgttt tagatatgaa gggagttcgg caggaaggct gtcgccatat 3895381 cccgccgaac tccatgctca gcttatgcca gacctaattc ttctttcatt ttcttaagca 3895441 taaatcggct tgattcatcc gctctttcat cgacccaagc aaatacggca ttcgtcgcaa 3895501 ttccgtcgaa cttcatctct ctcagttttc tgaaaatcgt atcaaaatca acctcgcctt 3895561 ggccaatgtc caaatgctgg tgaaccgtta ctttcgcgtc aggcggattg acgatgtagc 3895621 gaaggccatg agccgcttta tgattatagg tatctgcaaa taaaacatgt gtgaggcggt 3895681 cgccggcttc gtcaaacatg gtctcgatgt cgcctttgcc gtcatcatag aagaacgtat 3895741 gcgcagtcga gtagacaaga ttgatccaat ccttgtcaag cgcgcggatc atatccatcg 3895801 cacctttgtg cgtttcgata aaatcatatg gatgggcttg aagattgagt ttaatgcctt 3895861 ctttttcaaa gactggcaga agctcatcca tggatttgat aaatttttct tcacttgtta 3895921 aaggatcata ttttgaaccg ctgaattcgc tgttcatcaa atccacttca agttcaaccg 3895981 caatttcgat tgcccgtttc cagttgcgca ctgctgcctg gcggcggtct tcatcgggtc 3896041 ccgcccagtg gtaaagagga agaagcgatg aaagcttaac acctgtatct cttaaaaggc 3896101 gctttaattg tttgatcttt gctgaatcga ctttcggata tttataaaac gggcaaaaat 3896161 cctcgcgcgg cgataattcg atatattcat agccgagctc tgccgtttta tagaccattt 3896221 cctctaaagt taaatcatca cgatacatgg atggatccaa tgctaacttc atattttcac 3896281 tcctctgttt tttagttttg aactgttgta aaagattgat agaattccgg tttttccttc 3896341 aattcaacct tttctttttg tccagattcc tgggctttta cacacgcgtc agtcgtgaca 3896401 gcagcaatat agccgtccca tgccgtcggt ccgctgacct cgcctttctt ttgaatcgaa 3896461 tcaataaagt cttggatttc cacatcatac gcagcgacaa agcgtctctg ccaatccatc 3896521 aaaatatcag tgctgaatct gccttctttt ctcaagctga tgcttgatgg ctcgggaagc 3896581 ttgatgatgc cgtcttctcc gacgatttca cattgaatgt catagccgta tttacagttc 3896641 acatagattt cagcattgat gacgataccg ccttttgttt caatcacgac gatttgcgga 3896701 tcttttaaat gtggaagcgc gttttttgat tttttcggat agatgacttg aacggactcg 3896761 tagtcatcat tgacgagcca gtggagcacg tcaatttcat gaacaagcgt gtcgactaca 3896821 gccatatccg ttgtatagtt atctcctaca gtcgggttgc ggtgcgcgca gtgaatcata 3896881 agaggctcgc cgatgacatg attatcgagc gcttctttca gctgtacgta accgctgtca 3896941 taacggcgca tgaagccgac ttgaacaagg cgtttgccca ctttgatttc ttcttcgaca 3897001 atgcgcatgc atccttcagc cgttgtcgcg agcggttttt cacagaacac atatttctgg 3897061 gctttaatcg ctttcagcac gcttgactca tgcgcaggcc cccagcttgt cactaaaaca 3897121 gcgtctacat tttcgtctgc aagcaagctg tcatcattcg gataaaccgt cgcgtttaat 3897181 tggtattgct caacgacctt ttgtgcagct tcttgattaa catccgttac agctacaatt 3897241 tccgcgcctg acagcttgtt cgtgatacgg ttaatatgtt cttttccgat tgctccagtt 3897301 ccaattacgc caatacgtaa actcattgac agccactcct tctgttggtt acatgatttt 3897361 gctttctgtt cctttcttta cttggctctg aggagacccg tagagttcct cttgaatttg 3897421 ttcaagcgac ttgccagacg tattcggcgc aaagagcagc ccgatgatca tactggccgt 3897481 cacacatccg agaagaattg cagccatcgt tccaatgccg aaattggtga taatcattgg 3897541 gacaaacaga ctccaaatcc ctattgaaat acggacaagg aaaaacatca gtccttgtgc 3897601 ggaagcacga tattgcgtag gaaagatttc gctggcccat aactgatagt tcgcttgctg 3897661 cccggctccg ttattgatgc cgatcacgac aataaacagg agcagaatcg gcaggccttc 3897721 aactggcagc agaaacagtg tccacccgat caccgccatg aaagcggcga ttccaaatac 3897781 ggtttttcta tatttgtcgg caaagggcat gaagatcaag gcgaccccca atcctgtgaa 3897841 gataaacagc cccatttgca aaaggttggc catgttggca gatacaccgc cgacctgctg 3897901 ataaatgtat ggcataaaga agcccatgac cccggcggct aggttccaaa ccaagtacac 3897961 acccatcaaa aacaggatgc tttttagata cataggcttg agcaaatcaa aatacgatgt 3898021 cttattcaat acagccggct tctctgcctg agcttcctcc ggctgatttt ttgtctgcca 3898081 ggcgtctgat tccggaagcc tgattctcag gatgtacgta atcagcgcaa tcacaagcag 3898141 atgggcaaat acgattttat tccccaagag tcccaagtca ccggccagta cggagaggag 3898201 cagtacaacg acagcgcccg cggcccaagc gacttgtgct acgccgcaat gcctggcccg 3898261 attcttcttt ggcgcatttt ccgcaataat ggtccatgac gcggttatgt cagcccctac 3898321 tgataaaccg ataatgatgt aaccgcttaa caacatgggg aaattaaccc cgaacaaaac 3898381 caaacaaatc cctagtgcat aaaccagcat actattggta taaacagcct tccgtccgac 3898441 tttatcagcc agaaacccgc caagcagcgc gccgacagcg gcagaaatcg catttgcgct 3898501 caacgcgccg agcagcccga tttgcgtatc ggatagctta aggtaactga cccataatga 3898561 taaaccggcg gagcctgcca caattgaacc ggcatcaata tagttggcca atgctgccgc 3898621 gattgtccgt ttattgaagg ctgaatctcc attggtattg cccatatgtt cattccccat 3898681 taagccagat ccaacaactg ctgatcaata tagtttctcg caatcaatgc atactccagc 3898741 gggtttgcaa catcggggtc ttgttcagct tcaatgacaa tccatccgga ataactgtgc 3898801 ttcaacagca gctgatatac ttctctaaag tcaatgcagc cgtcaccggg aaccgtaaac 3898861 atgcctttta aaaatgattg ccggaacgat tgtccttcga gcctgcattg ttccatgaca 3898921 ttcaggcggg catccttaaa gtgcacatgc ttaatgcggc cgatatgctt ctcaagcatc 3898981 cccatgtaat cgccgtcaga aatatacgca tggcctgtat catagaggag gtgtacatgc 3899041 gcagggtctg ttcctgccat caggcggtcc acttcttccg ctgtttggac accagtgccg 3899101 agatgatgat gatagacaag cttcaagcca tgctgagcgg caatttcgcc aaggtgattc 3899161 agcccttcgc aaagccgctc ccattcatca tccgtaaagt gcggcttctc tgtgaacaca 3899221 tttttctcca agctttgcac gctgtacgtt tgttcagaga caactgcgac atccgcgttt 3899281 acttgctgca aatactcaca atgcagggta aatgtctttg ccgcttcacc aagtccgtca 3899341 cgcaaaataa aactgctgaa ccattttcct gcaatgcgta agttccgaag cttcagctct 3899401 ttgttcagga tggcaggttc ggggaaaaag cccccgacct ccgtgccttg aaaacgtgcg 3899461 acaacgatat cacttaacaa atgctgaagt gtatttcccg ctccaatttc aggcatgtca 3899521 tcattccgcc acccaatggg agcgattccc cacaggattt catttttgcc catctatggt 3899581 gcctcccctc taatactgct tcgcagattc cagctttttc tcttttgctt cgtatgcttt 3899641 ctgaacgctt tcttgttcag atacctctgc caccccgaca tgccaccagc tgtcatagcc 3899701 gtccgtcatt gttttaggca gcaccttcat ttcaattaat gttgatacat cctgtttctt 3899761 cgcatcctct aacgcagctt ttaattcttc tactgtgttt gcacggtagg ttttcgcgcc 3899821 gtatccctca gcgactttcg cgtaatcgac attcaggatt tggttgtcat ctgtgcggaa 3899881 ctcgcaatag tagctgccgc tgccgtgatc catttgcagg ttgttgatgc atccgaatcc 3899941 tgagttgtca aagagcagca cattgatttt cttgttgtac tgaatcgccg tgatcagttc 3900001 agaatgaagc atcaggaagc tgccgtctcc gacgattgaa tacacttctc tgtcagggtg 3900061 ggccagttta agaccgagtg tcccggacac ttcatagccc atgcaagaat atccatactc 3900121 caggtgatac gtattcggaa cattagaatg ccacagacgc tgcaaatctc ctgggagtga 3900181 gcctgctgaa cagatgatga cgctgtcttc aggaatcgtc tcgttgattg tcagcaatgc 3900241 cgttgtttgc ggaagctccg tattcaacgc gtcagcatat tcattcagga cctcttgaga 3900301 aaagtgattt ttgatttccg gatcaaatgc ttcccgctta aacgtcactt tgctgagacg 3900361 ctcgcgttca gctagccatt cgtccttcag ctcccggatc gttgtgccga actcgctctc 3900421 atagccttca agcaagccgt gcagtttgcc aagcgtcact ttcgcatccg ccaccacttg 3900481 gaatgcatca agtttatacg cctgcattcg gctgacgtta atgttcaaaa acttcgcttt 3900541 atcaaaatca aaagcggtct tagaggatgt cgcaaaatct gtataccttg tgccgatgcc 3900601 gataatcaaa tcagcttggc gggccgcttt gtttgccgca agtgtacctg tgatgcccat 3900661 tccgccaagg ttgttcgcaa aatctgcctc aacggtagac tttcctgcct gcgtttcaac 3900721 taacggaatg ttataggctt cagaaatggc aaccaattca tcgcgcgcac cggaatattt 3900781 tgcgcctccg ccgacgagaa tcacaggttt tttgctggat ttaatcagct ccgccgcacc 3900841 ttgaagctcg cgctcgctcg gctgcatgcg atcaatatag tgaacccgtt tgacgaagaa 3900901 actttcatca aaatcgtatg cttccccttc aacatcctga gaaatacaaa tcgttgccgg 3900961 acctgctttt gccggatcag tcatgacttc aaacgcgcgc agcaaactgc tcatcagctg 3901021 ctcagggcgc gtaatgcggt cccagtatct cgatacaggc ttcaatgcat cgtttgtcgt 3901081 aatcgccgca ctgtattctt gctccatttg ctgcagtaca gggtctggct gtcttgtcgc 3901141 aaatgtgtct gccggaatca agagaactgg gatattattt gccaatgcag tgccggctgc 3901201 cgccaccaag ttagccgctc caggtccgac ggatgtagac accgcatata tttttcttct 3901261 cagcatttgc ttgctgtacg ccatggccgc atgcgccatt ccttgttcat ttttcccttg 3901321 atagactttc aaatggcctg catcctgctc aagcgcctgc ccgatcccta atacgtttcc 3901381 atgaccgaaa atcgtgaaga tcccttcgac aaaaggctct tcctttccat ctacatggat 3901441 gtactgctgg tttaagaatt taatcagcgc ctgcgcagtt gttaagcgaa ttttcttacc 3901501 cacaaacgat cccaccttta ctcgatcttt ttcaattatg actgtgcttc aataagctgt 3901561 tcgatttctt ccgcagtcgg catcgcttct gacgaactgt gcttgctcac cacaatggag 3901621 gctgaagcac tgccgtattt caatgccgtt tcaatgtctt ttccgctgac aaggccatag 3901681 ataaaggctg acgcatagga gtcaccggcc ccaaaggttt tcagcacttt tgtcttgtac 3901741 gcttgagcgc ggaatacctc gccggatttg ctgtatgcgt aagagccttc gacgccgtgt 3901801 ttgatgacaa cgaggtcggc tgaatggcca aataaatgat tgacggattc ttcattgctt 3901861 ccgcctgtgc ggttttccat cacatcaaat tcatcgcgtg tgccgatgac gatatcagac 3901921 tgctcggcaa ccaaagaata ataaacggct gtttcatctg atgactgcca cgtatatggc 3901981 cggtaatcca gttcgaatac caccttaacc tgatgctttt tcgcgtattg aacagctttt 3902041 aacaccgctt cccgtgacgg gcttttggcg agcgctgtcc cggagacaag cagcattttc 3902101 gcatttgcga tatagtcctc acttacctct gaaggctcaa gataaagatc cgccacatca 3902161 tcgcgataca ttaagatgct gcattcttca gggctgagga tttctgtaaa tgcaaggcct 3902221 gctttgtgtc catcttgatc aacaatcatc tgtgtagtat ccacgccggt ctttctcata 3902281 taggactcta tgaatcttcc atgctggtca tccggaattt tgccgatgaa gcccgctttt 3902341 aagccaagct tcgcgctgcc gatcgcgata ttcgcaggtg aaccgccgac atatttcgaa 3902401 aatgtcatcg tttcttccat tgggcggttg tattcgactg cgttcagatc aatacatgcc 3902461 cggccgatgg caacaatatc aaaagccttc tcttcattga atgtatactt catcgtaaac 3902521 agccactcct cacttgttag cgttctaaaa tccattcatg cgccgggtcg ttataaaact 3902581 tccattttcg cgtcggccct gccatgacat ttaaatagta ggatgtgtat ccgtccggaa 3902641 cgcctaccgg gtggtatccc gcaggaacga tgacaacgtt ttcatttccc acagtcattg 3902701 tctcgtcaat agaacggtca tctgtgtata cgcgctgaaa cacaaagccc tgtcccgggt 3902761 ctaactcatg gtagtacgtt tcttctaaga aagattcttc cggcaagttg tcttggtcat 3902821 gtttgtgagg cgggtagctg gaccagttgc cgctgtctgt atagacttca actactaata 3902881 gactgttagc tgaagggtct gaatccggaa gaatgttatg aacagtacgt ttgtttgaaa 3902941 attgcccgcg atgctcaatt ccgttgtctt ccgctttgat cagctttgtc ggaagctgct 3903001 tttccgatgg agaatagcaa agcgccactc ttgcgtcgct gaccgctgtg atctcaaatg 3903061 cacggtcatt tgaaatatag acgctgtctg tcggttttcg ttcaaatacg ctttcgcgcg 3903121 tgccgatatt ctcaaaagtc gactcatgat ctgtcactgt aattttcccc gttaccgcca 3903181 caatacagat ttcttgtttt ttcaattctt ctgtatagct tgaacctgat gcaagatcta 3903241 acactttaaa ctctacataa gtgagatcag agttggatgt cgttacttcg tgcacgagtt 3903301 tgaccccatt agacacttca tgcgactgcg gcttacgcaa caaataactc atagagaagc 3903361 cctcctcttt ctattggcag aatgagtccg aacagcgcac atggacgccg ttcggctgtt 3903421 cgtcgtttag ttgaaatcag gtgccggata tcttgccgtc accacttttt tacgtgtata 3903481 gaagtcgacg ctgtcttttc cgttcgcatg cagcgttcca aagaatgaag atttccagcc 3903541 tgagaatggg aagaacgcca ttggagccgg cacaccaagg ttgatgccta gcattcccgc 3903601 atcaatgttt tcacggaagt agcggattgc gtttgagttg gatgtgaaca agcaggcgcc 3903661 gttcgcaaac tcagacttat tggcgatttc aatcgcttct ttcaggtttt tcacacggat 3903721 gacagataag accggagcga aaatttcatc tttccagatc gtcatttctg ttgtgacatt 3903781 gtcaaagatc gtcgggccga caaagtagcc gtcgtcagac acattttcac gtccgtcaca 3903841 tacgagtctg gcaccttctt caagaccttt ttcgatatag ctgagcgtgc gcttcttgtt 3903901 gtcttcgcga atcaccggtc ctaagaacac gccgtcatca aggccgttac cgattttaat 3903961 gtccgccact ttttcctgca gcttcgccat aaattcatcg gcgattcctt cttcaactgt 3904021 cacaaccgca caagccatgc agcgttcacc ggcagaaccg aaggcagctc caacgatgtt 3904081 tgtaaccgtg tcttcaagat tcgcatcgtt caagacaatc gtatggtttt tcgcgccagt 3904141 cagagattga acgcgtttta agttttcgct tccttttttg tagacgtatt cgcctactgg 3904201 cttggagcct acaaatgaaa tcgctttaat ttcgggatgc tcgaggatgc cgttcacaac 3904261 gtcatgcgca ccgtatacga cgttgaacac ccctttcgga aggcccgctt tttcaaaaag 3904321 ctcaaccaat ttctctgtta acagcggagt ccgctcagat ggctttaaaa taaatgtgtt 3904381 gccgagcgcg atcgccatcg ggaacatcca gcaaggaacc atcatcggga agttgaatgg 3904441 cgcgattccg ccgacaactc cgattgggta acggtagttc gccgcttcaa cgtccgttgc 3904501 gatggaagca agtgagtcac ccatcatcag ggaaggtgct ccagcggcga actctacgtt 3904561 ttcaatcccg cgtcccactt cacctaaagc ttctttcgtg ttttttccgt tttcaatggt 3904621 aattagatga gcaagttctt ctttatgctg agacagcagc tgctggaagt taaatagaat 3904681 tctggcgcgg cgaggaaccg ccacctttga ccatgtttta aatgcttcag ccgctgtttg 3904741 cgctgcgtaa tcaatatcct cttttgtaga aatcggcact tggcatagca cttctttcgt 3904801 cgccggattg acgacatctt catattgatc tgttttgctt tcaacccatt caccgttgat 3904861 gtagtttttt aattttctga tttctgccat tcttattgcc tccttcatta gtaaacacat 3904921 acacttgtat ggatggttcc ggatagattc atatcaatat ccacttttca gcaagccaag 3904981 aattaaacgc tttcaaaaac accaaaaaaa taaatggcgg atgcatattt acatacaagc 3905041 aaccatttca tgcacaacag gttacttttt ggtcatttct tggttatatt ctaatcgcat 3905101 aatacccata agtcaatcat aaacactaca ttttttcatt atttttatta tattaatctt 3905161 ttaatcaagt aagagaagta agagaaggcc gtccaatctt gcaaaagata tacaccgatg 3905221 ttatcatttt taagcaacta ttgattaact tttggttttt attatatatt tatgttacgt 3905281 aaagattcaa gaaggagttt tttatatgaa actgatgcgg attcaggaaa tggaggagta 3905341 cattttatcg catggcactg tttccttaga tgagctgtgc caggtgttca atgtctccaa 3905401 aaacacagtc agacgtgata tcaacaagct aacagaaaag ggtgcgattg aaaaagtata 3905461 cggcggcgta acatctattg aaaaaaccgc attagttcct tttgaaaatc gcaccattca 3905521 gcaccaggat gaaaaaacaa aaatcgccca ttatgcttcc cgatttattg aagatcacga 3905581 tttggtcttc attgattcag gaacgacgac aaagtctatt cttgatacgc ttgatccagc 3905641 caaaaatgtc accatcttaa ccaacagttt agacattatc aatgcggcgt cagctttgaa 3905701 gaatatcaac ttaatcatta tcggaaacaa ctataagaga aaaacccgct cctttgtcgg 3905761 catggacgac ccggctatgc ttgataagta caatatcaac aaagccttta tgtccgctac 3905821 cggaacgacg ctgactcacg gattgaccaa ttcggatctg ctggagtatg aaattaaaaa 3905881 gaggatttca gaaaaagcaa aagaagtgta tctattggct gaccattcta aattcggaaa 3905941 atcaacgctt ctgacgtatg caccgtttga caggctgcat tgcattgtga cctctcagcc 3906001 attagacgac gagtacacgc agtactgcaa tgagcatcaa atcggcattc atctggccta 3906061 acgtttacaa tagtgttgag agtctatcat ccattttatt ctaggaggca gatcatgaaa 3906121 aaagcgaagc tcggaaaatc agacttgcag gtattcccta tcggattagg aacaaatgct 3906181 gtcggaggac ataacctcta cccgaaccta aatgaagaaa ccggaaaaga attggtgcgc 3906241 gaggcgatcc gtaatggcgt gacaatgtta gacaccgctt acatttacgg gatcggccgt 3906301 tccgaagaat taattggtga agtgctgcgt gaattcaacc gtgaagatgt tgtcatcgcg 3906361 acaaaagccg ctcacagaaa acaaggcaat gactttgtct ttgataattc accagatttt 3906421 cttaaaaaat cagttgatga aagcctgaag cgcttgaata ccgattatat tgatttgttc 3906481 tacattcact tccctgacga acatacgcct aaggatgaag ccgttaacgc gctgaatgag 3906541 atgaagaaag ccggaaaaat ccgttccatc ggtgtatcca acttctcttt agagcaattg 3906601 aaagaagcaa acaaagacgg tttggtagat gtattgcaag gcgaatacaa cctgttaaac 3906661 cgtgaagcgg aaaaaacatt cttcccgtat acgaaggagc ataatatttc atttatccct 3906721 tacttccctc tcgtatcagg tttattggca ggaaagtata cagaagatac aacgttccca 3906781 gaaggcgacc tgcgaaacga acaggaacac ttcaagggtg agcgtttcaa agaaaatatc 3906841 agaaaggtca acaagcttgc gccgattgcc gaaaaacaca acgtggatat ccctcacatc 3906901 gtattggcct ggtatttagc aagaccggaa attgatattt taatcccagg agcaaaacgt 3906961 gccgatcagc tgattgataa catcaaaaca gctgacgtga cgctttctca agaggatatt 3907021 tcatttattg ataagctgtt cgcataagaa gaaaacagcc ttctccaatg gagaaggctg 3907081 tttttttgtg cgataaattc ctaaataact gattttgaag caaaacctta caaaatgagc 3907141 cataaatccg ataaaataaa ggtagtttat ctcagaaaga aagtgattga gaaagcaaaa 3907201 gtatgaaacg ttcatatcat ctagctcata tgaaataaag ctgacccagc ttcttttatt 3907261 tgctggtcag aatagcggac cgtttcgatg gtctatggag gaaacagaat gaaacttaaa 3907321 tatgtaaaag ccttagttgc agtaaccgtt gctttaggtg tactgctgcc atcaacgatt 3907381 tctcatgcaa agagctttag cggccgctca tcatctagtt acagcagccg aagttcaagc 3907441 tcatcataca gcggaagcta taaatcaagc ccgaaatcaa gctacagctc aggatcaagc 3907501 tcttctagca aaaaatccaa gacgtctgac gattcatcat catcgatttc gcttaaaaag 3907561 aagccttcgg aaaaggcaag ttcatcaagc tctaaaaaat cgtcaggcac cttttccggc 3907621 gctacatcaa aagtaaccgg aaagacatac agcggaaaaa cgtctaaagc ctatgttggc 3907681 ggacgttatg tttcagtcaa tcattactat cacgcaggtt tcgcgccatc aggatggttt 3907741 ggatattata gcggatttac aatgggtatg ttcatgatca gcatgatgca cccatggggt 3907801 tacacctatc atccagtcgg aggccccggt tatgtttctt atggcgcttc acccattgcc 3907861 tggatcgttg atatcatcgc tttgattatt attttaatca ttgtcatcgc attgattcgc 3907921 gcatttaaag caccgaagac gtacagaagg agattttagg caatgagatt aatattaaat 3907981 gagcaagaaa ttgtagacgg aatttgcgtg tatatttcca atgaagaaga tatctaccct 3908041 gaagacgttg aagtaaaaga actatcgtac aacaagcgta cagggttctt cgctgaagct 3908101 acatttggcc tgcaccacaa gcagcttatg tcagatgaca tttcagaagg cattattcag 3908161 ttcttagagg aataccacaa cttcaatccg gacgttaccg tcgttgaatt gcaatttgat 3908221 aagaaaaaag gcttctccgc cttggttttt gtcaacgaag cagaagaata aaaatgtctt 3908281 aatcaaacct tactccgcgc gggtaaggtt tttttaatgg tttctctgag cataaagtta 3908341 tttcgttttt cctaaactca gcggatctgt gatcatctct tttggctata aagtttccgt 3908401 tttttcaaaa caaatgtttc aaatgagata ggaaatgggt actaatctat taactttgtt 3908461 acatattttt agatactcat tggctcaaca actgaggagg agacatttgt gaagaaagac 3908521 acaaggaaat atatgatcta ctttttcggc gctttagggg gactgctata tggttacgat 3908581 acaggtgtta tctccggagc actcctgttt atcaataacg atattccttt aacgacattg 3908641 acagaaggat tggttgtcag catgctgctc cttggcgcga ttttcggttc tgccttgagc 3908701 ggcacatgct cagaccgctg gggcaggaga aaggttgtat ttgtcctttc catcattttt 3908761 attatcggtg cgctcgcttg cgcattttct caaacaatcg gcatgctgat tgcatctagg 3908821 gtgatactcg ggttggccgt cggcggttca acggcacttg tgcccgtgta tctttccgaa 3908881 atggcaccga cgaaaattcg cgggacactc ggcacaatga acaacttaat gattgtcacc 3908941 gggattttgc tcgcctatat cgttaactac ctgttcacac cgtttgaagc gtggcgctgg 3909001 atggtcggtc tggctgcagt gcctgccgtg cttctattaa tcggcatcgc cttcatgccg 3909061 gaatcgccaa gatggctcgt gaagcgcggc agcgaagaag aagcgagacg catcatgaac 3909121 atcactcatg accccaaaga catcgaaatg gaattggcag agatgaagca aggggaagcg 3909181 gagaaaaaag aaacgacact tggcgtgctg aaagccaagt ggattcgccc tatgcttctg 3909241 attggcgtcg gccttgccat tttccagcag gcagtcggca ttaacacggt catctactac 3909301 gcgccaacca tttttacgaa ggccggtctt ggcacatcag cttcggcgct cggcacaatg 3909361 ggaatcggca tcctcaacgt catcatgtgt atcactgcca tgatcttaat tgaccgtgtc 3909421 ggccgcaaaa aacttctgat ctggggaagt gtcggcatca cactgagcct tgctgcttta 3909481 tcaggcgtgc tcctgacact ggggctttcc gcatcaacag cgtggatgac agtagtcttt 3909541 ctcggtgtct atatcgtctt ttaccaggcg acatggggtc cggtagtgtg ggtgctcatg 3909601 cctgagctct tcccgtccaa agcacgcgga gccgcgacag ggttcacgac tttggtgtta 3909661 tcggcggcta acctgatcgt gtcgcttgtc ttcccgctga tgctaagcgc gatgggcatc 3909721 gcatgggtct ttatggtttt ctcagtcatt tgtcttctct catttttctt cgcgttctac 3909781 atggtaccgg aaaccaaagg gaaaagcttg gaggaaattg aagcaagcct gaaaaaacgg 3909841 tttaaaaaga agaaaagcac ccaaaaccaa gtgctgaatg agcgtacatt ataaaaaaag 3909901 gaatcgtctc cttatgagac gattcctttt tctgtttaca ccatgacctt gcaaatattg 3909961 ttcgtaaatt ccacagggtc ctgaatcggc aggccttcga tgaggagcgc ctgattgtac 3910021 agaaggtttg tgtacaggct cagcttctct ttatcttgtt caaacgcgtc ctgcagtgtt 3910081 tggaatacct cgtgatttgg gttgatttcc agcacttttt ccgccttcac attttggctg 3910141 tcaggcatcg catttaagat tttttccatc tcaattgtca cttcgccgtc agcagcaagg 3910201 cagactggat gtgatttaag ccgttttgag attctgacgt ttttcacttt gtctgacaga 3910261 atgtttttca tttcctcaaa cagatcctta tacttgcttt cctcttcctc ggactgcttt 3910321 tgatcctcat ccgtgtctat gccaaggtct ccgcttgata cggacttgaa ttctttttcc 3910381 tgataagaag ccagcatttt aattgcaaac tcatcgatgt cctcagtaaa gtagaggatt 3910441 tcatagcctt tgtccgccac catttccgtt tgcggcagtt tctcaatgcg gtcgtaagaa 3910501 tcaccggtcg cgtaataaat gaatttctgc tcctctggca ttctggaaac atactcgtct 3910561 aagctgacca gttttttctc ttttgaagag tagaataaga ggagatcctt caattgatcc 3910621 ttattcgcgc caaaatcatt gtacacgccg aatttcagct gtctgccgaa cgacttgtag 3910681 aacgtctcgt atttctcgcg gtcttttttc aacaggcttt gcagctcgct tttgattttc 3910741 ttgctgatgt ttttcgcgat cagcttcagc tggcggtcat gctgcagcat ttctctggaa 3910801 atattcagcg acagatcctc agaatcgacc atgcccttca caaagctgaa gtggtccggt 3910861 agcaggtctg cgcacttatt catgatcagc acgccattgg aatacagctc caagcctttc 3910921 tcatattcct tggaatagta gtcaaacggc atgttttcag ggacgaatag aatcgcgttg 3910981 tagcgaaccg ctccatccac gctgatatga acgtgtgtca gcggtttatc aaacccgtaa 3911041 tgcttttcag catagaattt ttcataatcc tcatctgtca gctcgctttt gttttttctc 3911101 cagatcggca ccatgctgtt gaccgtctgc tcttcctgca cctcttcaaa ttcattttcg 3911161 ctgccttcct tcggcttatt aatggttgta tccattttga tcgggtagcg aatgaagtcg 3911221 gagtacttct tgatgatcgc ttttaaacga tattcctcta aaaactcgtc atagctgtca 3911281 tcttctgtgt tctctttgat tttcaggata atgtctgtac cgacagaatc cttttcacac 3911341 ggctcaatcg tatagccgtc tgcacccgca gactcccatt tataagcctc ttcgctgcca 3911401 agcgctttac tgatgactgt cacgacatcg gcaaccataa atgccgcgta aaaaccgaca 3911461 ccgaactgcc cgataatgtc atgtccgtct ttcagctcgt tttccttttt aaacgcgagg 3911521 gaaccgcttt ttgcaattgt tccaagatgc tgttcaagct catcctttgt cattccgatc 3911581 cccgtatcag agatggttaa tgttctcgca tctttgtcag ctgcgacctt tatgtagtaa 3911641 ctgtctttat caaacgtaag cgcatcgtcc gtaagcgctt tgtaatagat tttgtcaatc 3911701 gcatcactcg aattggagat taactcgcgc aggaaaattt ctttttgggt ataaatggag 3911761 ttaatcatca tatccagcaa gcgtttagac tctgctttaa actctttttt cgccactctt 3911821 gatcgctcct ttaccattat gtaaaccctt ttcagcatct atttatcaca taagatgaca 3911881 attgtcaatt agattgatag atgcatatat atgtaaattt aacattagtt ggatttgttt 3911941 tcactctttt tctcactcat tctcataaaa aagagaggct tcatcatcct ctcttttttt 3912001 ctgtgtcatt ccaacggcca aactcccgct tcatccatat atgcaccggg tagaaaaaca 3912061 aaccgaacgg tatcaaaaac aaaagattat gccatgaagc attcagaaat gcgcttgcag 3912121 tcaccgggaa cgtaatctct tgcaataaaa aagagatgac agtcagcaca acaaatgcag 3912181 atggaatggt cacgatgcaa taaaacttga gctccttctt atgctgtacc ttcaaacata 3912241 caaacctccc aacaatttct aattcatctt aacatatgct ggcctttctt ttctcgcatg 3912301 tttatcactg cacatagcgg gaagacaaat agaaaaagga ggtctcgtat catgggaaga 3912361 cttgaaaaca aaacagcagt tatcacaggc gccgcgacag gcattggtca agcgacggcg 3912421 gaggtttttg ccaatgaagg cgcgcgtgtg atcatcggag atatcaataa agatcaaatg 3912481 gaagaaacag ttgacgcaat cagaaaaaac ggaggacagg ccgaatcctt tcacctcgat 3912541 gtgtcagatg aaaacagtgt gaaagcattt gctgatcaaa tcaaggatgc atgcggaacg 3912601 attgatattc tgtttaataa tgccggcgtt gatcaggaag gcggaaaggt gcacgaatat 3912661 ccggttgacc tgtttgaccg cattatcgcc gtcgacctgc gcggcacatt cctttgcagc 3912721 aaatatttga ttccgctcat gctcgaaaat ggaggctcca tcatcaacac ctcctccatg 3912781 tcaggccgtg ccgcggacct tgaccgctcc ggctacaacg ccgcaaaagg cggtatcacc 3912841 aacctgacaa aggcaatggc aatcgactac gcacgaaacg gcatccgcgt caattccatt 3912901 tcaccgggca cgatcgaaac accgctgatt gacaaattag caggcacaaa agaacaggaa 3912961 atgggcgaac aattccgcga agccaacaaa tggatcacgc cgctcggacg tcttggccag 3913021 cccaaagaaa tggcaacagt ggcactgttc ctcgcatcag acgacagctc atacgtcaca 3913081 ggagaagaca tcaccgcaga cggcggcatc atggcgtaca catggcctgg gaagatgctg 3913141 attgaggaga aatggaagga agaaacgaaa taagagaggg agccccctct ctttttgtct 3913201 tttaaagcaa tacaacctta tatttcttca catccaaaaa ctgcaaaaac tccctcgcca 3913261 gcacttcagg cggatgcgcc tttccttcat ccagccgata caaaagcaac ccgataatca 3913321 ttgcggatac ataatgggca taaagctttt tctctgcgtg aatatcagtt tgctgatgca 3913381 gataaaacga ttccagcgct ttgaacatat caggtatcac atgaggaaca ccccattccc 3913441 gattgagaaa atggacaatg ggcatgtttg acaaagcaga aagcagaatg gcgagcgcct 3913501 tctccgcttc ctttaaggaa aattcattcg ggctggaggc aatcgtcagg tgatcaatga 3913561 tctccgcaca tgatcgctgt atcatggttt ggagcaattc ctccttattg gcatagtgat 3913621 cataaaaggt tgcacggcgg atattgcttt tacgcgtaat atctgaaatc gtgatgcccg 3913681 cgtagtcttg tttctccgcc aatacatcca gaaatgcctt ctgcagcgcc tctctcgttc 3913741 gaaccacccg cctgtcgatt tgcttctcct tctctcgctc tcctggcaca gcttttccaa 3913801 acagccaata aaaccgcttt tgagaaacaa gctcccatac cttctggctg atggcttcag 3913861 gagacgcggc cgcatcctca ttcagccaat acaggataat cgcgtacgtg tacaaggccc 3913921 gataatgtcc ataaatgtcc cgttcaatcg gcgttaaatt cacatggatc ggagccagca 3913981 gcacatcctg ctgaaacaca tccttaaaaa aacgatgaaa atgtcctctg ttcatcatca 3914041 cagaaaaaaa ggaacgatgc tcatgaacaa aggacagcgt cggatgcacc gtttgccgtt 3914101 ttttgttcaa atgaagggta tccatatgac tgaaggcgtc aaaaagcgct ttgcccagtc 3914161 cttccttcat gtcttcgatc acatcctcaa tgattgaaaa cttatcctca taataaaggt 3914221 agagcgatcc gcggctcact ttggccttct cagcgatttc tttcattgtg atgtgttgaa 3914281 tatctctatc tttcaataaa gccagcagcg cctctttcac ttgagcttcg gcagattccg 3914341 gcacaaaaga cacctccaat cattagacag atcttagata tatgtacggt aacgtataga 3914401 tggttcaccg ttgtctttct tacagaaaag gtaccacctt ataataggtc cgagaaaaga 3914461 agaaagcaaa tgagggggat tttacaatgg aacagcaagt aaaggacgac atccagcgtg 3914521 tctttcagct tcagaaaaaa cagcaaaaag ccttgcgcgc ttcaacagcg gaacagcgga 3914581 gagaaaagct tcaacgcttt ttagattccg tcatcgccca tgaagaagaa atcatcgaag 3914641 cgatccgcaa agacgtccgc aaaccatatc acgaagtcaa aaaagcggaa atcgaaggaa 3914701 caaaaaaagc gattagagat aatatgaata acctggaaca atggatggcg cctaaagaag 3914761 tcggttcatc gttaagccct gacgcaaacg gaattcttat gtacgagcct aaaggcgtca 3914821 cactcatcct cggcccgtgg aactatccgt ttatgctgac gatggcgccg cttgccgctt 3914881 ctctcgcagc cggaaacagc gcgattgtga agctgtccga tttcacgatg aacacgagca 3914941 acattgctgc taaagtaata agagacgctt ttgatgaaaa agaagtcgcg atttttgaag 3915001 gagaggttga ggtggcaacc gaactacttg atcagccgtt cgaccatatt ttcttcactg 3915061 gaagcacaaa tgtcgggaaa attgtcatga cagcggctgc caaacacttg gcatctgtca 3915121 cacttgagct tggcggcaag agcccgacga tcattgacag tgaatacgat ctgatggacg 3915181 cagcgaaaaa gatcgccgtc gggaaattcg taaacgccgg ccaaacctgc atcgcacctg 3915241 attacctgtt cattaaaaaa gacgttcagg acaggttcgc ggggatttta caaacagtcg 3915301 tcaacgctgg atttatggag gatgatcata ccccagaccg cagcaaattt acgcagatcg 3915361 tcaatgaccg caacttcaac cgcgtcaaag atctgttcga cgatgccatc gaaagagggg 3915421 cggaagtggt gttcggcggc gtattcgatg ccagcgaccg cacgatctcg ccaaccgttt 3915481 tgaaaaacgt cacgcctgac atgaaaatca tgcaggagga aatcttcgca tcgatcctgc 3915541 caatgatgaa ctatgaagac atcgacgagg tcatcgatta cgtaaatgac cgcgataaac 3915601 cgcttgcact ttatgtgttc agcaaaaacc aagatctgat tgacaacgtc cttcagcaca 3915661 cgacatcagg aaatgccgcc atcaatgatg tcgtcgtcca tttcagtgac gtcaacctgc 3915721 cattcggcgg cgtcaacaca agcggaatcg gctcctatca tggggtatac ggattcaaag 3915781 agttttctca tgagaagggt gtatttattc aggccgctga ataatcgcat gatcaaaagg 3915841 cgcttcctta gaggagcgcc ttttattgta actccttgac caaaagcaat tcatcacgga 3915901 taggtatttt attatctgcc agtaaaggaa tttcgggctt catctttctg gccgtctcga 3915961 ctgcattcac aaatagtcga tccaaccggt accctctctt ctgataaaac gctaatgcat 3916021 gaatattatc attggttgtg atcagtttta tttgtttgat atttctctct ctgcatgctt 3916081 cctcggcttt ctctagcaga gctgttccga tccctttatt ctcaatgaca ctatccagcg 3916141 aaatgatttc acaggcatct tcttcaaata tgtatgtaat aaggccaaca atctggttat 3916201 catcgttgag cattccataa ccatctaatt catcgcagtt ataaataccg ctagaaataa 3916261 ccatttgcgg actgccccag tgtttttgaa aaaacgcgga aacaagatct ttaggtacct 3916321 ggcatgtcgg aataatattc atattttcct ccttttagct gaacaaaaat aagagaatta 3916381 acaacctatt ttatgtcatt aatcccctta tctagtattt actagaactt ataacttgtc 3916441 aaaagctgtc tgaataccaa ttgcgtggat tgataaggat caaaatctga atcctgagat 3916501 tggaagattt gctctggggt caatgtctct gcgttctctg ataacgtttg aatcagactt 3916561 tccaaatatc catttaactc tgatttggac gattcatgta gggattgatg atttacagcg 3916621 agttctctaa atctgttatc actgattaat ttttttcgaa gagctgctag catcaagtca 3916681 agccatgcag gctggccaaa tgtaatattt aaagctaacg ttgcttgatc agatttggtg 3916741 gagtgccata aacctcttgg caaatacagc atggttcccg gtgttaaatt aacgatttct 3916801 gcatctggca gatcctcttt tggcggatct cctttccaat atgactgtaa atcatcagga 3916861 tagtaaggag cctctgataa atcatagtgc tgcattggat tgctcacatt ttcattcttg 3916921 gcaagcttcc atgttttctc accttgaatt tgaaaaatca agttggtgta ggcgtcaaaa 3916981 tgggctttga atcccccgcc atttttcgcc gcgtaaacaa tggctttgga agaagtaccc 3917041 gcaggcagtc ttaattccgc tttgagtttt tctatccacc ttctgacttg gggaataaat 3917101 aggtcggtga aatcaaactc taatgcagcc cctttttcat accactctaa agcctctgca 3917161 ggtgacacaa gaaatctgtc tgtgatccct tcagattctt caatcacagc atcaccaacg 3917221 accatgactg gattattgta gatagccaat acgttttcta gcgttctaac cttttcaaac 3917281 cccggtatgc ttgtaaatct ctccacttct cctctggcta ccaaaggttt tacaggccaa 3917341 tattcttcta aaaactcact catcgttaca ggactgatga tagactccaa aaccgattcg 3917401 gttacagcac tcatattatc cctcccaaaa aaagtaactt caccacaaag atataacatt 3917461 tttttctaaa agtaaatatt gacagaatta tcagaggatt ataatattta gttgtgcgtg 3917521 atagcctatt tttttacaag gaaggaggga aaaggatgaa aaaggcttat aagaaacctc 3917581 gtctttttga actgcgccgt gctgtagcag ctggcggcca ttaatctcat atagcatttg 3917641 acatctagta ctctatttta ggagggatgc tcaatgaaaa aagcttataa gaaacctcgc 3917701 ctttttgaac tgcgccgtgc tgtagcagct ggcggccatt aatctcatat agcatttgac 3917761 atctagtact ctattttagg agggatgctc aatgaaaaaa gcttataaga aacctcgcct 3917821 ttttgaattg cgccgcgctg tagcagctgg cggtcattaa tcttatccaa aacgattaac 3917881 gtttgaggct atcacgccaa cttgataagg aggatgctga agatgattac ggctgaagaa 3917941 tgcagaacgt acaaagaatt tgttgatctt taccaatcct atctttaccc cttgcttggc 3918001 gccagactgt cccggatgta ttcccccaaa aacaaagtca ttatcgatat gggcacaggt 3918061 ccaggttatt taagcattca gttggctaaa agaacaaatg cgcacgtgca tgctgtcgat 3918121 attaacccgg ccatgcatga aatcgctcaa gaagaagcta aaaaaagcgg agtaagcagc 3918181 ctgatttcat ttgatttgga agatgtccac catttatctt acgctgacca atatgctgac 3918241 ttcatcgtct cctactcttg cctgcatcat tgggaagacg ttgttaaagg acttaaagag 3918301 tgctatagag ttctggctcc gggcggaaaa attgtcattt tggatacatt taatccccaa 3918361 ggaagccatt tagagattat gcgaaaacaa atcaaagaac cggaatactt caggtttgta 3918421 agagaggcat ttgaagaaag ttattccttt gaagacattc accagtttgt tcaggatgcc 3918481 ggcattccca attattcatt agaaaccttt cactttttac cggaggattt tatagaaagc 3918541 ttagatgagc tggaggatgc tcccctgtgg gaacaaaatg atcaaagtac tgatcatgaa 3918601 attgagtctg tcacatggat gttaacgata gaaaaagaaa aggaaggtgc attgtaatga 3918661 tcaatgaatc aactgtttta tccaaaaatc cagaaatgcc atcaagaaaa tatttgaaaa 3918721 gcattattat agagccgggc atcactttaa atgaaatggc atcagatatt tataaccata 3918781 tcgacggcaa ggtcagcata catgatattt gctcaaaaat cgtcaatgaa tatgatgttg 3918841 attatcaaac ctgcttagaa gattgtatgg agctgtttga gttgcttatt gatcatgaag 3918901 caatcaaagt taagcagggg gcatgagaat tggaaaaaca aaaagtgctt gctttaccag 3918961 acgatgtaca tgagctgagt acacaccgtt ctaaatcaat cgtaaattac atcatcactc 3919021 tgcttgcctt tgccaaaaaa caaggattga ctcatcaaga tattgtaagc tggattcacg 3919081 agcaatatga ggaaagagga tattatgatg agtggagaca cattaacagc caacaaccag 3919141 ttggatcatt tgtggaactc tttataaaag gaagacgttt actttatgac aaaattgaat 3919201 tgtttgaaac agaagataaa tatgtcgtaa atacccacac ttggtatgaa aaagaaccta 3919261 gtgaggcctt tttttatttt gaaattgatc ccgaagaatt ttctgcgtac gcttccattc 3919321 tcgcaatcga aaacgcaaaa cgtctcggaa ttaaaatcga tattgtaaaa gaaacagatg 3919381 tagagacagc ttatatctat aaacatcaat aacgctattg ggagggagac atatgtgcgg 3919441 gctcgcgggt attataaatc tggctgctcc ccgttctcag gaatgtacct ttcatatatt 3919501 gaaaggcatg gcagatgcca tcagctatag gggaccggat gatgaacaat atcatattga 3919561 ttccaaagtc ggctttgcat ttcggcgatt gtccattctt gaccttgtaa atggacagca 3919621 gcccttttta aatgaggatg gatcaatcgt cgttatggta aatggagaaa tttataacta 3919681 taaagaactg aaggcttctt tacacaatca tatgtttaaa acgacatctg attgtgaagt 3919741 aattgttcat ttatatgaag aaaaagggat tggatttgta gacgacatca tcggaatgtt 3919801 ttcaatagcc atttgggaca aaaataaaaa caaagtattt ttagttcgtg accgctttgg 3919861 gattaaaccg cttttttaca cagagctaaa acacgagctt atatttgcct ctgaaataaa 3919921 atccctattt tctcatcctc actgtccccg ccaatttaat tggaaagaag cactctcaga 3919981 catttggcta agcggggaag cagccagtaa tcataaagaa accacttcct tttttgtaaa 3920041 catccaaaat ctcgatgctg gccattatct cgaaattaat ttgacaacaa atgaacgaaa 3920101 aacagcaagc tattggtctt tacaggatat tttgctcagg caaggctatc gtgagaatct 3920161 ccatcccgat gacctgattg aaggatatag agaactgctg gcagattcag tccatagatg 3920221 tttacaaagc gacgttgaag tcgggttgtt tcttagcggt ggcattgatt cagctgcagt 3920281 cgcacatttt gctgcagaaa aacaggatct ccatacgttt acagtattaa gccaaagtac 3920341 atttacaaat gaagatgcaa aatatgccca ttggctggct aaagatttac accttccaaa 3920401 tcatcaggtt ctctatcaat tagggaacga tgagttatta caaccagagt catataaaca 3920461 tttgttatgg atctgtgaaa caccgttttg cggaccggaa caattatata agtttcattt 3920521 acataagtat gccaaagcga taaggccaaa cctgaaagtc atgctgaccg gccagggcag 3920581 cgacgaattt aacggcggtt acagcacgac actttcacca gccgagaacc caagttggga 3920641 aggatttatt gaatcggtca atacgatgga gatgaaccgg ctgcatcggc tgcagggaaa 3920701 tatctttaga gtgtgggagg agcattttgg actttctcct ataaaccttt cttatttaaa 3920761 gagcaatgat tccagccaag cagatccttg gcaatcgtat gtcctgacaa aataccgtga 3920821 tctgcaaatg tataattgct ggcatgaaga tcggatcgcc gcggctaatc atatcgaaaa 3920881 ccgtgtaccg ttcttggacc atcggcttgt tgaatgggtt tgcggaatac ctgatggact 3920941 ccgtaaagac ttgttatggg ataagtcggt attgcgaaaa tcattaacaa atgagctgca 3921001 tacaagctat acccaccggc caaaggttcc ttttttctat ggtaaggacg tgagatatac 3921061 acataaaatg atgtttcatc ttctgaagaa aaacaattat cagcttatag aggaggcctt 3921121 ctctcacagc gatgcctcca gcataataca ggttgaacac attcatgcca tcatgacata 3921181 tttggaggat gatcctgagt ttacaaattt tgaattttta ttaagactgg tgaacatggg 3921241 acttttatca aaaatgacta aagaaacccc ttctgttcaa ttagacataa ccagccattt 3921301 agaatcgata acaataaaag actggcactc acaggaaggt gatattgcca gtcgtttaaa 3921361 tatctcagcc aataagtgtg aaggacaaga tattttggcg ctaaaccctg gcgtcactct 3921421 gttaaggccg gaaagcgata gtgagcattg catctacatt gcggaagaag gatttattca 3921481 gtttattgtt tcggaggaag acgtcggagc ttggctgcat attctctgcg atattaatgg 3921541 aaaagacaca cttcatacga ttttagacag acatggtgtc agccttgaag aagtggccaa 3921601 atatattcaa gaagccatcg aacacaatat cattttgatc aaacaaaaaa atctgccaga 3921661 aggagcatat agatgagcat cttttattcg ttttccgcac ttaggggatt agcaatgggg 3921721 attttttcgc ctatttggat tctttatctg atatctaaag attatgattt ccttcagatt 3921781 ggattaatgg gagcggtact tgaaattgct aagcttatat ttgaagttcc ttccggcgtt 3921841 tttgctgatc gttatggaat taaaatttca attgccagtt cattcttttt ctccatcctt 3921901 acatgggcct tcttcccttt tatcgattca gctgctattt gcatactggc tatgatcata 3921961 tgggctttat cagattcctt aatttccggt tcttttgaaa cttggatgag ccgtgtcgca 3922021 ggggaagatc gattcggcaa agaaatgatg aaaaacacac aattgctaat cactttttta 3922081 attattggaa gtattgccag cgggtatttg tattcattaa atatctattt tcctttcctg 3922141 ctcgttatgg tgatctactt attactattt atttggatgt ctgtatttat taaagtccct 3922201 tctgtttccg aaacaaatca tggggatcag aaccaacatg attcgataaa gattatcaaa 3922261 gaaagtttaa aaattatctt taacaaaaaa agggttcttt taatcgtcat agccggtttc 3922321 tttacagcca cagcctatga cacaatttcc cgttactggc agcctttttt gagtgattta 3922381 ggcttttcag aaaagtcact gggatatatt tttgccctag gagggtttac cgctctcgtt 3922441 cttttgacat taaccatcag gttcgaaaag aagatcgaaa aaaatccata tctcgcttta 3922501 acctcattgg attccatggg catggtcatg acttttctat tgtctagagc attcaggccg 3922561 ctgggcattc catgtacagc gtttttgctt gcaattgaag atattcatca tccgatcgta 3922621 acaagttact taaataagtt tttccccgat tcatacaaga acacactttt ctcgttaaac 3922681 tcaggggtag gagcaattgg agaaattctt tccggtgtca ttttcggcat catttccgca 3922741 gcctttgggc tctctgccat gtttgttgtt gtagctgtat ttctattaat ccctattatc 3922801 ctttatacga tagtgcctaa gattaaagac aatgatatga aagttcagat tgaaaaatcc 3922861 cagcaagtgt aaatgttttg tatcacagta agaagacctt cttattaaaa gaaggtcttc 3922921 tgctattcta ttcagttatt tcccaaaagc catcagcttc gtataacttc caatataaag 3922981 tgttccgtcc tcagcgagct gaggagaaga cacgacgttg ctgtcggttt gatagctcca 3923041 taattcattg ccgtttgcgt ctgccgcata aaccttcata tcatctgacc cgaaataaac 3923101 cgttcccttc gcgtcaatca gcggcgccgt tctgacaggg ccgtctgtgt agaatgacca 3923161 gttcatatcc ccgtttttgc tgatggaaaa cagctcgccg cttcctgagc cgatgtagat 3923221 attgccatta tgatcaatcg caggagatga gctggagaac ccgtttagcg ggaatgtcca 3923281 tttcaaactg cctgttgatg tataagcata cagctgtcca tcttggttgc cggcataaat 3923341 gtttccgtcc ttatcaatca ccggatatcc tttaaacgca tttgacgtcg ttctggacca 3923401 tttcacctgt ccggttccgg agttgatcgc ataaaacacg taattatatg tgccgacata 3923461 cacggtgccg tttttggcaa gcaccggcac agagctgacg accccatttg ttttcaactt 3923521 ccagcgctct gtccaggttg attttgacgt cggtttgatc gcgtgaacat aattatcaag 3923581 tgttgagaaa tacaacgtcc cgtctgaacc gatcaccgtt tcagagcttg gcccgccgct 3923641 taacggaacc gttgttaaaa tttctcccgt ttctttgtca ataaaataaa tctttttgtc 3923701 ataggatgcc aaatagataa cgccgttggt cccaagtaca ggagattgcg tatatgtttt 3923761 tccaagattg cccgtcaccc atttgactga gccgtctgga ttaaaggctt tcatttcccc 3923821 gtctctggaa tgaagatata ctgtgccgtc tccgtcaatc acagcccccg ctccattttg 3923881 cggagtcgtt ctgatgtcgt tttgccattt cagcgtcccg tctgtatttc cggcgaaccg 3923941 gctttcgcgt gaccagttaa acatggcagg cgccatcgct tgtacatcat atcttcctgg 3924001 caaaaagcca gatgctccat tattttgaga aaacaccgtt tccgccgcat aagcagctgt 3924061 cggctgaagc actttggcag cgggcacatc agaaacagcg ccggccgaaa cagccgccgc 3924121 caccgcagct cccgcaatca aagctttcat acgaaatgac ttgaccatca ttgagacccc 3924181 cattatatgt aacttctaat ttgtgaccat cataacatat tcatccattt tataaatcta 3924241 tttcacaaaa acatcacaaa ctagaaaact atgtaagagt attcacggac gttttttcag 3924301 cacccgatcg aaatgcagcc acaaaccaaa tgacgttgac agcagccgca gcgagactaa 3924361 ctcccaaaac aaagatcacc tcagaaagca gatggtcact aaagaaacta aacatcaaga 3924421 taaaaccggc cgaagacaaa tgaatcaaaa gcccgaagcc gcaaagcacc gccatgacat 3924481 acctcattgc atcgactccg agcatataaa cgagaaatgg aatgaaatac aagacaagga 3924541 tcataccgac agctgaccac atgccagctg aattaaactg attggccgcc gctcccgttc 3924601 cggccagcgg cgaaagtgaa gccgccacaa tcacggcgca aaaaagaaac gcagaaatgg 3924661 ttgtcatgat cgccacgcta tttttttttg acatcaaact cctcctttaa tagaaatatt 3924721 aacctttttt attataagta agttgaatgt tatattcatt atatttttaa aaaattccag 3924781 aatacataca caaatgctat gcttctttct agtatattta tatagtaaaa aacaaaggat 3924841 aaaagactca tttttctgta atatcaggat tttatcacca taccatattg catgtacatg 3924901 tttttcaaag tatactattc cagattaatt cagaggagag agaaaaatac atggaaaaac 3924961 cagcaggatt ttggattcgt tttttagctt attttattga cggcattatt gtatctgttc 3925021 ctagttatat tattctattt attatcaatt ctgtgtttgt agctggggct gtggcaacaa 3925081 acccttacat gacggaagaa gagtatttag tgaaatacat gacgcttgca tttttgccta 3925141 ctatgctgat catgatcgtc atcagcgtgt tatattacgg gctgctcaca gcttctaaaa 3925201 tgcaaggcac acttggcaaa aaaattcttg gcctgaaagt ggtcaatgaa caaggtgaac 3925261 gggtttctgt cggacaggga attggccgtt actttgccta tatcttatct ggaatcatct 3925321 tttatatcgg gtttatcatg atcgcctttg gagagaaaaa aggcctgcat gacatcattt 3925381 gcaaaacacg tgtcgtgtat aaataataga aaaaagtcta gacgccaata ggcatctaga 3925441 cttttgtttt ctttgcaata ggctgccacg acagatacgt agcgcttctc cacaaccact 3925501 caaacggccc catccgaaag acacgaagcc aaaggtggct gaagaccatt tgaacggcac 3925561 aaacagcaat tgtaatgagc acaccggcag cagggtacac ttttccatac aggcccaagc 3925621 cgtaatgata aaaaatccaa gtacacacaa tagactgcat caaataattg gtaaatgcca 3925681 tcctcccaac agcggagaat gattgcagca ctgttctcac tcttgtttta tgataaagat 3925741 agacaaccgt tgtaacatag aaaaacatga ggaaaggcgc gccaatcagc aaacatattt 3925801 ctttatccgt tacactgtac agcacctggg cgccgatgcc gatgacaagc ccagccatcc 3925861 ataatcgttt taatcctttg cgatgctttt ccggttcatg caaataccgt gattttgctg 3925921 ccgcagctcc cagcaaaaac atgctgaaat atggaatgga tgcaaagaag tagttgagcg 3925981 gattatacgt aagcatgcca ttcgaagaca tgtaaacaag acggtcgtgg atccgctgtt 3926041 ctgcaatatc cttcaggctg ccgcttccat aaacatgaat cgcttgtttt gcctgctgtg 3926101 ttaccgcttg tacccattcc tgtccgtttg attgatcaaa acttgtcaac atgaacggaa 3926161 tggaaaacag aagatacaaa gagaccgccc atatcagcag tgttttcggc tttgcttttc 3926221 gaaacaagag caggacaaat ccgagcaggg catattctgt taaaatatcc ccgtcccata 3926281 tcaaaaaggc atgaatcgtt ccaaacaaga gaagcgccat taaccttctc acatataacg 3926341 gaacaaaccg tttccctttg ttttctgctc tctccatcat gacaaccatg ccaaatccaa 3926401 ataaaaagga aaacaataaa atacattttg tttgaatgaa gaatttcagt atgtctgcgg 3926461 cggcaaaatc agcttcagac cacttatcca tgaaaaaatt ctcttttcca agcatagaca 3926521 aatacatatc cggataactg aaatgtgcca gattgacaaa taagatgccg aaaatcgcca 3926581 ttcctctcag cacatcaagc acaccgatcc gctcatttgt taaagtcggc tgtaatgaag 3926641 acatagccat cacgctcctt ttttctgtac cttaagggta ggaaaaaatg aagcgcggta 3926701 acatcgattt aggtgtcagg ccggcatgaa aaccttacaa tcttgtcatc tttatggttt 3926761 catcaccttt aaatctaatg cttcgatatt ctgcaaaatg cgatcaaagc gcaaagcctg 3926821 aggctcacat gggaagatgt ggccttcata cgggtcgcct aacgtccgga aaaacggttc 3926881 aaataaacca ggaaccaata cgcccaccat ctttgtatag tgagaatcaa ggcgatagga 3926941 gtgaacggta tttgcaggga catgcaggaa atctcccgga ttcagctgaa tttcctggcc 3927001 atctgtccac atcgtcatct ggccttcaag gcaataaaat gtttctgtat gatattcatg 3927061 gtagtgatca acgattcggt cacctttagg gccttcagat gatacgacga taaactggcc 3927121 atctgtattt ttttgtgcag ccacaatgcg gtgaagctga tctccagtca acagacgatc 3927181 tccttctcca gattcaagaa cgtatggaac cgctccatct ggcagctctg taagttccgc 3927241 taatttggcc gaacatgcag gctttgcttc atctagaaat acaatgtccg ctacagcggc 3927301 tgcttctgca aatcgctcgt ttgagacttc ttcgcttgcg tacggcggat gttcagcgtg 3927361 atcatacgga ttcccaataa cggaatacaa gtgcgctacg tttcctttca tcgtgtaaga 3927421 caccagtctt gttctgtggc tctgcatccg gtagctgtgc ggtgttcccg ccggaatgtt 3927481 ggcataatca cctgatatta ataaatagcg ttcaccatca agtgtcagtt ccagtttccc 3927541 gtccaaaacg agaattcctt catgtgtgtc cttgtggacg tgaagcggaa aggcatctcc 3927601 ttttcccccg gaaagaagca cgatctcaaa caaatcacct gtgctcctcc cattcgccat 3927661 caccgtggca acctgtctgc cgaacagata gcgctcgcct tctccgctcc ggagcaaata 3927721 aggcattttt tctttaggca atgaatgtgt acataatgtt ttcatattat cgcttcctcc 3927781 aatttagacc agtctatata ttatcattca tttgtctaga ccgttctata taattgtagg 3927841 agaaaggata acaaaatgct accctttttt tctcaccagc actggtattt gttcggcaat 3927901 gagaagaaga ggcgttttgt ctttattcgt taacgaaagc atgatgccgc cctcaatcat 3927961 cgaattaatc agcgttccaa gctgatttgc ttcttcttct gcaaatccgt tttccattaa 3928021 ttttctggca aaaaccgctt cccagctttt aaacaccttc atgcaaaccg tccgcagcgg 3928081 ttcactgatt aacgctgtct cactcgccag caaaccgact ggaatacctt taatgctttc 3928141 tgtgttgtca aattggctgg ctgttttttt gataaaaagc tgaatcgctt caacaggatc 3928201 agaggattca tccatgcttt gctgtatcag atgttcaacg atcttacctg tatatgtaac 3928261 cgcttcaatt gctagttctt ctttgccatt cggaaaaaag tgataaagcg atccttttgg 3928321 agcaccgctt tcttttacaa tctggttcaa acctgtcgcg tgatatcctt gcagctggaa 3928381 cagacgtgac gccgtgtgaa ggattttttc acgtgaatct cctctgctag tcattaaaac 3928441 attccctcct aggtatggta gagcgactta tataatataa aaaagaaccc tgtgattgtc 3928501 aaaaggggta agacccttcc ggatggggta atgtacaaaa acagcgtcta ggagggatct 3928561 ctcaatgaca atcgatcatt cagtcacaaa tacagagcag cttgaacaac agaaccccgc 3928621 cataaaaaca aagctcaaac tgaaaaagct taaggatcag gtgatcgtca ttaccggcgc 3928681 ttcaagcggt atcggacttg tcacggcgag aatggcagct gaaaaaggcg caaaggtcgt 3928741 ggcagcagcg cgaaatgaag aggcgctgaa ggagctcact gatgaactta aggaaaaagg 3928801 gcacgacgcc atatgggtaa aggcggatgt cggaaaagaa gaggacgtca accgcatcgc 3928861 agaaaccgcg atcagcacat tcggccgctt tgatacatgg gtcaacaatg cggccgtctc 3928921 gactttcgga cacgccatgg acgtcaccgt cgaagacatg aagcgcatgt tcgacacaaa 3928981 tttctgggga cctgtttacg gaacaagagc ggctgtcaaa cactacaccg gcagaggtgt 3929041 gccgggcgca ctcattaatg taggaagcct gttcggagac aggggaacgg tcattcaatc 3929101 cacatatgca tctgccaaat ttgcgcttca cggctggacg gaaagcatcc gaatggagct 3929161 tgaaaaggaa caggcgcccg tctcggtaac gctcatccac ccgggcagaa ttgacacacc 3929221 atataacgag catgcgcaca gctacctcga caaacagccg gctcattacc gctccatgat 3929281 ctatccgccg gaagcggtcg ccgaagcgat cctgtttgcc gccgaacacc ctaagcgcga 3929341 catgtacatc ggctcacagg ccaaagccat cgccatgctg ggcgcgcttt ttcctcgtct 3929401 gaccgacaga ctgatggaaa aaatcatgta tcacagccag catgccgaaa gaccgtccaa 3929461 tccgagagaa gaaagcgctc tttatgatgc tggctgcggt atgcatgaca gaggcacaaa 3929521 taaaggatgg atgaggtcaa gaagctacta cacaaaagcg acgaagcgcc caattgtatc 3929581 ggcggctgtt gttgccggac tagtggcttg ggctgccgcc aaacgatgca gataatctct 3929641 gaccataaga aaaacccatg ctgttccagc gaaccatggg tttttcagct gttaatcgat 3929701 aaaagccttg ttcatacgct gcagcagctc gccgaacatc tctttttcct gtgttgacca 3929761 ttctttcagc atctgttcat aacgttcaag gcgcttttgc tgatcggctt ttaatagttg 3929821 tttgccgagt tttgtaatgg taaacaggct gactctccca tcagacgggt ctgagaaacg 3929881 atagatgagc tcctttgcct ctaatgcagc tgcttgtctt gaaagagtag aaatatcaag 3929941 cttaaacgat tcagccaatt ccttaacacg agcaggccca aactcatcca attgtctcag 3930001 taataagtac gaagatctct ccaaattccc tgttcttttc tccgattgat ccagataaac 3930061 agctctcctg ataaaagtcg tcagctcata ttcaattaat tcaactggat tttgattttg 3930121 caatcgctct cgctccctat tccaatctcc ggcattgaca acatcatata tacttgtata 3930181 atacaaatgt acattaactg aataaataca agtcgttata tgactaaatc aattattata 3930241 cttgtatagt acaatcatat aaaaagaaag taaagcgatt cctcagaacc atcctagaag 3930301 caagcaccag aaaggaggaa gctgttctga ttggagagca gcacttgatg tgaaagtcat 3930361 acgaattatt ttgcaagtgt tgatattata tgtatttttt atgatcgggg aagccattca 3930421 gcatctgttt catttacccg tgtcaggaag catcgttgga ttggtattgc ttctgatctg 3930481 cttgggcctc cgtattgttc ccgtctccat cattgaagac ggagcagggt ttttattatc 3930541 cttccttcca ttgttgttca tcccggcaat gacaggagtg ataaactatc cgtctctcat 3930601 ttcattcaat ggcctgatgc tgctgattac agtcgttctc agcaccatcg tcacgatcat 3930661 tgcggctgga ttcgccagcc agctattaga gaaaaaagca aaaaaacggg aggagaaaga 3930721 gaaatgcagc aagcatgtat cgcgatcatt ataattcttt taacagttgc cgcttattta 3930781 gcgatggtca aactctataa gcgattcccg cttccatttc tgatccctgt tctgacaacg 3930841 acaattttga ttgtagcggc tttgatgatg tttcatgttt cctatgaagg ctatatgatc 3930901 ggggggaaat ggatcaattc tttgcttggg ccggctgttg tggcgctggc ctatccgctt 3930961 tataagcaat ggcatatcat tgtcaaacat tgtgttccca ttttaggcgg cgtcctggtc 3931021 ggcttatgca tgggaatgat cagcgggctg atcttcgcag aagcattcgg gattgatcat 3931081 gatctcttat tatccattct gccaaaatcg atcacaaccc ctgtcgctat tcagatcgcc 3931141 gccggtcttg gcggcgtccc ttccatgaca gtcgtatttg tcatgattgc gggcttttca 3931201 ggcgtcatcc tcgggccgct tttcctaaaa tggcttcgca tacgcagctc cctaggacaa 3931261 ggcattgcat taggcagcgc ctcccatgca ctgggtacct ccaaagcgtt ggaatatggg 3931321 gaattggccg tatccatgag ttccgtctcc atgacgcttt gtgcggtgct cggctcattc 3931381 ttcggcccgc tcgtcgtctg gctgtttcat atttaacaaa gaaagactgc cccgggggag 3931441 ggcagtcttt ttcgtttaag aagcaaaaaa atcaatcaac ggctgaaagt ccttagataa 3931501 atcaacgtca ttcggttctg cttgaagcag gcggtcaatc atacgctcca gctcctcaac 3931561 atcattctta tccgtatatt caatgaagtt taagctttca agccaatccc gatatgaatg 3931621 tttggctttg ccatagctgt ttccaaagac aaggcaaggt gttttggtga taatcgagaa 3931681 aatcatcgcg tgaaggcggt cggtaatcac caatttactg gagccgatgc ggtccagcat 3931741 ctccataaaa tgcttttcac gatcagcgta atcgatggtg tctaccgtat ccagcaccgt 3931801 atcggtacgc tctgtgtaag ttgttttttc tgcccattgc ttcatctgtg aaataaaatc 3931861 ttcgtcagtc actttctcct tatccgctct taaaataaag agaacgccgt cccgctcgag 3931921 ctctcgcggc acaatatcca aggaaagcac catgtccggt gtaaagatca cattggagtt 3931981 gaaggtctct ttcacaacat ccagtgtttg cgtctcacgc gcagcaatcg ttaagtttgt 3932041 attttgatgg tacgcatcct gtgttttttt cttttccttc tgtccttcct ctgtatcctc 3932101 aaaataaacg gattgtggca gagaaattga tttgtagtct ttaaacgccg aaaagacctt 3932161 tcttctgtct tcctcaatat cgagataaag gtttcctaaa ttccctccgc ctgtaaagca 3932221 gacaatatcg tcttcacgaa tgatctcctt caccagttca atgccctcat ccgtcgcata 3932281 atccataatc tcaatgtatt cataatacgg aaaatgattt ttgataaatt tctcttccgc 3932341 atacgcaatc gcttggtcgc caatgtttgt gtagctaggg gaaccaaaca aaaatacttt 3932401 tcgtttatca tttaacagag cttccggctc cacatttggc gcaatgcctt ttactagttt 3932461 tttgcctttg atttcttgta cagtcatatc tgcgtcctcc ttctgggatg aattcctcat 3932521 tgtgtgttaa ctgtctctac ccaaaaagaa ggatggctat gcattggcat gtgcatcggc 3932581 tatatcagaa acatcgtttt cgccaatttg atagacgctg caatgtcccg cgccgttctt 3932641 tccatatatt ccgcggcatg ttcaaacgcg tcttctagtg gcacggctcc ggggacgatg 3932701 ctgaaaagcg catcgattcc gtgttgatag acggcattac tgtctcggga aattgatccc 3932761 gcaatgccga taacgggcac atcgtatgat ttagcggcct tggccacccc gatcggtgtt 3932821 tttccatgaa ccgtttggct gtcgattcgt ccctcgccgg taatcacaag gtctgcatcc 3932881 tgaacgatac tttcaaaatc aaccgcttca aggacaatat caatgcctct tttcaggtca 3932941 gcctgaagat aagttagcag gctccatcca agaccgcccg ctgcaccggc gccctctgta 3933001 tctcggaagg ttgatccgag cgctttttct gccatatcag cgaaatggct tacgttctgg 3933061 tctagtacat ccaacatgtc ggccgtcgcg cctttttgcg gcccgaaaac agccgtagca 3933121 ccctttggtc ctgttaacgg attgtccacg tcacaggcaa cttccagttt gacattccgc 3933181 aatctggaat caagcccgct cacatctatt gatgcaagct gagataacgc gccgccccct 3933241 gggccaatct cgctgcctga gttatcaaga agccttccgc ccaatgcctg aatcatcccg 3933301 gctcccccgt cgttcgtggc gcttccgccg attccgatga tcaatcgctc cgctcccgca 3933361 tcaagagctg ctccgattaa ttctcccgtt ccccttgttg tagtgatgag cggatttcgc 3933421 ttatctacag gcaccagatg cagccctgaa gcagcagcca tttcaatcac agctgttctc 3933481 ccatctccca tcatgccaaa gaaagctctc accggttccc ccagcggccc tgtgacaact 3933541 tgctctatga tccttccatt ggtcgcatcg accagagatt gaacggttcc ctcgccgcca 3933601 tccgccaccg gcaattttct gtaatcagca cccggaaaga ccgatttgaa acctctttct 3933661 atcgcttcgg ctgcctccag agctgataag ctttccttaa aagaatcagg tgcaatgatg 3933721 attttcatcc aaatcgcctc tttcaaaaca tgattcactt aacctattga tctccaatgt 3933781 accataattg atctggaaat acataccatg caatatggta aaaatttaaa taaaaattag 3933841 aaatgaaagt gtttgcataa aagaaatatt cacgttatca tacttgtata caagtatact 3933901 ccttgagtga ggaaggtgag tgtatgctag actccaaaga cctgttgtat cccgcaaaat 3933961 ggctctcaaa agcgtcaacc ggagttcgtg tcgcatacga gctgagaatg cggatcgttt 3934021 caggtctgat tgaaagcggt accattttat cagaaaatac aatcgccgcc gagttttcag 3934081 taagccgttc gccggttcgc gaagcgctaa aaatactcgc atccgaaaaa atcatccgct 3934141 tagaacgaat gggagcggtc gtaattggtt taactgagaa gaaaatcgcg gaaatttatg 3934201 atgtgcggtt actattagaa acatttgtct ttgaacggct tgtcaaaata gacattgagc 3934261 ctttagttaa ggatctcagc aaaattcttg aaatgatgaa agtctcaatc aaatatgagg 3934321 atgctgacga attttcattt caagatgtgc tgttccatga aacgattatc cgagcgattg 3934381 atcattcata cattcagatg atctggaaca atctaaaacc cgtcatggaa agctttattc 3934441 ttttatcgat gcgggtacgg ttaaaggaaa agtatgaaga cttcacaagg attttagata 3934501 accacgagct ttatattcaa gccatcaaaa caaaggatag ggcgctgatg attcagtctc 3934561 ttcaccaaaa ctttgatgat gtgcaggata aggtagaaga cctatggctc tcacaacaaa 3934621 tgctggcaaa aggagctgaa tacaacaatg actagttata tgttaggaat cgatatcggc 3934681 acgacaagca caaaagctgt gctgttcagt gaaaacggag atgtggtaca gaaagaaagc 3934741 atcggctacc cgctctatac accggacatc tcaacagctg aacaaaatcc ggaagagatt 3934801 tttcaggcag tcatccatac aacagcgaga attacaaaac agcatcccga aaaacggatc 3934861 tctttcattt cgttcagcag cgccatgcac agcgtcattg caatcgacga aaatgacaag 3934921 ccgctgacgc catgcattac atgggccgac aacagaagtg aaggctgggc gcataagatc 3934981 aaagaggaat tgaacggaca tgaggtgtac aaacggacgg gaacaccgat tcatccgatg 3935041 gcaccgttaa gtaaaattgc ctggatcacg aatgaaagaa aagaaatcgc ttccaaggca 3935101 aaaaaatata tcggcatcaa agaatacatt tttaaacagc tgttcaatga gtatgtcatc 3935161 gattactcat tggcatcagc gacaggcatg atgaacctga agggcttgga ttgggacgaa 3935221 gaggcactgc gcatcgcagg catcacgccg gatcacttat ccaaactcgt gccgacaacc 3935281 gagatctttc agcactgcag cccggaaata gcgatccaaa tgggaatcga tccggaaacg 3935341 ccttttgtca tcggcgccag cgacggcgtg ctgtccaacc tcggcgtcaa cgccattaaa 3935401 aagggtgaaa tcgccgtcac catcggtaca agcggtgcca ttcggacgat tattgacaag 3935461 ccgcaaaccg atgaaaaagg gagaattttt tgctatgcct tgacggacaa gcattgggtt 3935521 attgggggac ctgtgaacaa tgggggcatc gtccttcgct ggatcagaga cgagtttgcc 3935581 tcctccgaaa tcgaaacagc gacacggctg ggcattgatc catatgacgt gctgacgaaa 3935641 attgcccaac gcgtcagacc cggttctgac ggtctgctgt tccacccata tctcgccgga 3935701 gaacgcgctc cgttgtggaa tccggatgta cgcggctcat ttttcggctt gaccatgtcg 3935761 cataagaaag agcatatgat acgcgcggca ttggaaggcg tcatttacaa cctgtacacg 3935821 gtgttcttgg cgttaactga atgcatggat ggcccggtaa cccgcatcca agcgacaggg 3935881 ggttttgcaa ggtcggaggt ttggcgccaa atgatgtcgg atatcttcga atcagaggtt 3935941 gtcgttccgg aaagctacga aagctcatgt ctcggcgcct gcattttagg cctgtatgca 3936001 acaggaaaaa tcgattcttt cgacgccgtg tccgatatga tcggcagcac atacagacat 3936061 acgccgatcg aagactcagc caaggaatac agaacattaa tgccgatttt catcaatcta 3936121 tcaagattat tagaaaatca atatacacaa attgcagatt atcagagggg cttaatcaca 3936181 cacaaatagt acatgacatg aaggggaggg cattaccatg ccgttaatca tcgttgcact 3936241 tgggatctta gcattactat ttctgattat gggcttaaaa ttaaacacat ttatttccct 3936301 gctggtcgta tcgttcggcg tggcactggc actcgggatg ccgttcgata aagttgtcag 3936361 ctccatcgaa gcaggaatag gggggactct tggccacatc gcgctcatct tcggactcgg 3936421 tgcgatgctg ggcaaactga tcgcggattc aggaggcgca cagcgcattg cgatgacgct 3936481 cgtcaacaaa ttcggtgaga aaaatattca atgggccgtt gtcattgcct cattcattat 3936541 tgggattgcg ttattttttg aagtaggact ggttctatta attccgattg tctttgcgat 3936601 ttcaagagaa ttgaagattt ctattttatt tctcggaatc ccgatggtcg cggcactatc 3936661 cgtcacacac ggtttcctgc cgccgcaccc gggacctacg gcgatcgccg gtgagtatgg 3936721 cgcaaacatt ggagaagtgc tgctgtacgg ctttatcgtt gctgttccga cagtgctcat 3936781 tgcagggccg ttatttacaa agttcgcgaa aaaaatcgtt cctgcatcat ttgcgaaaaa 3936841 cggcaatatt gcatcactcg gcacacaaaa aacatttaac cttgaagaaa cacccggctt 3936901 tggaatcagt gtctttactg caatgctccc gattatcatc atgtcggtcg cgaccattat 3936961 cgacctgctt caagaaacaa tcgggtttgc agataacgga gttttagctt ttatcagatt 3937021 gattggaaac gcatcgactg ctatgattat ttcgttattg gtcgcagtct atacaatggg 3937081 catcaagcgc aacattccag tcaaaaccgt gatggattct tgttcaactg ccatttcaca 3937141 aatcggcatg atgcttttga tcatcggagg aggcggcgcc ttcaaacaag tgctgatcaa 3937201 cggcggtgtc ggcgattacg tagcagactt attcaaagga acggcattat cgccaatcat 3937261 tctggcatgg ctcatcgcag cgatcctgcg catttctcta ggatcggcga ctgttgccgc 3937321 actaagcaca acaggtctgg tcattccgtt attgggccat tctgatgtta acctggcgtt 3937381 agtcgtactc gcaacaggag ccggaagtgt catcgcttca cacgtcaatg acgccggctt 3937441 ctggatgttc aaggaatact tcggattaag catgaaagaa acattcgcca catggacatt 3937501 gctggaaacc attatttccg ttgctggact gggattcatt ttattgttaa gtttagttgt 3937561 atgaaattaa gaaggagctg taacacatgt tcaattcgat tggtgtcata ggcttaggcg 3937621 taatgggaag caacatcgcc ttaaacatgg caaataaagg cgaaaacgtc gctgtctata 3937681 attacaccag agatttaacg gaccagctta tccaaaagct ggatggacaa tctctcagcc 3937741 cgtattacga gcttgaggac tttgttcaat cgttagaaaa accaagaaaa atctttttga 3937801 tggtcacagc gggaaaaccc gtagattccg tcatccaatc attaaagcct ttgcttgaag 3937861 aaggcgacgt catcatggac ggaggaaact cccactatga agacacagaa agaagatatg 3937921 acgagctgaa ggaaaaaggg atcggctacc tgggagtcgg catttccggc ggtgaagtcg 3937981 gtgcgttaac agggccttcc atcatgccgg gcggagatcg cgacgtctat gagaaagccg 3938041 ctcctatcct gacgaaaatc gcagcccaag tcggagatga cccttgctgt gtctatatcg 3938101 gaccaaaagg ggcagggcac tttacaaaaa tggtgcacaa cggcattgaa tatgccgaca 3938161 tgcagctgat tgcagaagct tatacgtttc taagagaaac gcttcgtctg ccgctagatg 3938221 aaattgcatc tatttttgaa acatggaatc aaggtgagct gaaaagctat ttaatagaga 3938281 ttacagctga gattttacgc aaaaaagacg aaaaaacagg acagcctctg atcgatgtca 3938341 tccttgataa aaccggccaa aaaggcaccg gaaaatggac gagcatgcag gcgattgata 3938401 acggcatccc gtccacgatc atcacagagt ccttgttcgc ccgctacttg tcatctttaa 3938461 aagaagaacg gatggcagct caagatgtat tagcaggccc ggaagccgaa gaaaaacact 3938521 tggataaaga cacttggatt gaatacgtca gacaggctct ttacatgggg aaagtatgcg 3938581 cctatgcaca aggctttgcc caatataaga tgtcatctga gctttacggc tggaatctgc 3938641 cgctcaaaga catcgccttg attttccgag gcggctgcat catccgcgct gatttcctaa 3938701 acgtgatcag cgaagcattc agtgagcagc caaatctggc taacctgctg atcgcgcctt 3938761 atttcacaga taagctccat gcctatcaaa caggcctgcg aaaagtcgtt tgcgagggta 3938821 tcagcaccgg aatctctttc ccatgcttaa ctaccgcgct ctcttattac gacggctacc 3938881 gcacagggcg ttccaatgcg aacctcttgc aggcacagcg cgattacttt ggcgctcaca 3938941 cgtacgaacg gactgatatg gacggcgtct tccatacgaa ttggtctgaa taacctgtat 3939001 taaaaacacg gtcagtttca actgaaccgt gtttttttct tctatcccaa acaacagaag 3939061 acataagtta tgttttaaat atcataaaca gtgatacaat aatagctaga aacaatcccc 3939121 aagatcatca tgtgacagca gattgctgtt ccgttctatt ctgcttttgg ccattgtcct 3939181 ttgcccttga ccatggtgtc ataaaatgtt caaatgccaa aacggcctgg cattctgatt 3939241 tacaaaagtc cctgaaaacc ttatctaatt gagaatcagc ctctcattta ttataaaaga 3939301 aatgcctaaa tcctacctgt cacaccttta ttaagatgaa aaaaagtagg ttatggcttg 3939361 acaaaaaata tatattaatt aataattcat atataattag aattattatt gaaagcgatt 3939421 atgctttcta atacattttt aggaggaata tacattatgt ctttaatcgg taaagaagta 3939481 cttccattcg aagcaaaagc attcaaaaac ggtgaattca tcgatgtaac aaacgaagat 3939541 ttgaaaggcc aatggagcgt attctgcttc tacccagcag atttctcttt cgtatgccca 3939601 actgagcttg aagatcttca agaacaatat gctgcactta aagaattagg tgttgaagta 3939661 tactctgttt ctacagatac tcacttcgta cacaaaggct ggcatgacag ctctgaaaaa 3939721 atcagcaaaa tcacttacgc aatgatcggt gacccatctc aaacgatctc tcgcaacttc 3939781 gatgttcttg acgaagaaac tggccttgct gaccgcggaa cattcatcat cgatccagac 3939841 ggcgttatcc aaactgttga aatcaatgca ggcggtatcg gccgtgacgc aagcaacctt 3939901 gtaaacaaag taaaagcagc tcaatacgtt cgtcaaaacc caggtgaagt ttgcccggct 3939961 aaatgggaag aaggcggcga aactcttaca cctagccttg atctagtagg taaaatctaa 3940021 ggagtgcatt caattggtac ttgatgcaaa tatcaaagca caattaaatc aatatatgca 3940081 gctaattgag aatgacattg ttctcaaagt tagcgcaggc gaagatgaca cttctaagga 3940141 catgctggct ctcgttgatg agctggcttc catgtcatcg aaaatttcag ttgaaaaagc 3940201 tgaattaaac agaacgccga gcttcagtgt caatcgtgtc ggagaagaca ctggcgtgac 3940261 tttcgccggt atccctctgg gccacgaatt cacatcatta gtgttggcgt tgctccaagt 3940321 gagcggcaga ccgcctaagg tagaccaaaa agtcattgat caggtgaaga agatcagtgg 3940381 tgaataccac ttcgaatctt atatcagcct gacatgccac aactgtcctg atgttgtaca 3940441 agctttaaac atgatgagcg tgctgaaccc gaacattacg cacacgatga ttgacggtgc 3940501 agcatacaaa gcagaagttg aaagcaaaaa catcatggca gtgccgaccg tttacctgaa 3940561 tggcgaatcc ttcggaagcg gccgtatgac gcttgaagaa attcttgcga aaatgggcag 3940621 cggcacagat gcatctgagt ttgctgacaa agagccgttt gacgttcttg tggtcggagg 3940681 cggacctgct ggtgcaagtg cagcgatcta cactgcacgt aaaggcatcc gaactggtgt 3940741 tgtcgctgag cgcttcggcg gacaggttct cgacaccatg agcatcgaaa acttcatcag 3940801 cgtcaaagcg acggaaggac cgaagctagc ggcaagtctt gaagagcatg tgaaggaata 3940861 tgatattgat gtcatgaacc ttcagcgtgc gaaacgcctt gagaagaaag atctgttcga 3940921 acttgaactc gaaaacggcg ctgtcctgaa aagtaaaaca gtgatccttt caacaggtgc 3940981 acgctggcgc aatgtcaacg tccccggtga acaagagttc aaaaacaaag gtgtcgcata 3941041 ctgcccgcac tgtgatgggc cattgtttga aggcaaagac gttgcggtaa tcggcggcgg 3941101 aaactctggt atcgaagcag cgattgatct tgcaggtatt gtcaatcacg ttactgtact 3941161 agaattcgcg ccggaactga aagcagacga agtcctgcaa aaacgtctct acagcctgcc 3941221 taacgttact gtcgtgaaaa acgcacaaac aaaagaaatc acaggtgatc agagtgttaa 3941281 cggcatcaca tatgtagacc gcgaaacagg cgaagaaaaa cacgttgaac ttcaaggtgt 3941341 attcgtccaa atcggtctcg tgccaaacac agaatggtta gaaggaacgg ttgaacgcaa 3941401 ccgcatgggc gaaattattg tcgacaaaca cggcgcaaca agcgtaccag gcttatttgc 3941461 tgccggcgac tgcacagaca gtgcgtacaa ccaaattatt atttctatgg gatcaggtgc 3941521 aactgccgcc ctcggcgcgt ttgattacct aatccgtaac taatataaga aatccgctat 3941581 attgccagat tggcaggata gcggattttt ctttttctac agaaaaaaac cgaaccaggc 3941641 actacggtaa aagtgctcga ttcgagcgct tcttatagtt cctcaccatt cgtttgaatg 3941701 acatttttat accactcaaa ggagtctttc ttatatcgtt tcatggatcc gtttccttca 3941761 ttgtcacgat caacatagat catgccgtag cgttttttca tttcgccagt tgtgaaggag 3941821 acaatatcaa taatgcccca cggcgtgtag ccaattaaat caacaccatc gtacgtgacc 3941881 gcttttttca atgcttcaat atgcgatttt aaatattgaa tgcgttccgg atcatgaacc 3941941 ttgccgtcct cctccagcgt atccactgcg ccaaagccat tttcaacgat gaataacggg 3942001 atttggtatc ggtcataaaa acgatttaac gtatatctca acccggttgg atcaatcgcc 3942061 catccccagt cactcgaagt gatgtacgga ttttcgacac cattcggcaa gccgccattt 3942121 acaatatcgc cagtgttatc atttttcaca tcgcttttca cagttgttga catgtaatag 3942181 ctgaagccta agtaatcgac ggttccgttt cttaaaatct catcatcgcc gtcttcgaat 3942241 gtgatgttgt agccttcgcg ttcaaattcc ttcaacgcgt agcttggata ataaccgcga 3942301 acctgcacat cagggaagaa atagcgctgc ctcatttctt cttcagccag catcacatct 3942361 tcaggattgg aggagaaagg ataaatcggc acgtgtgata ccatggcccc aatctggaac 3942421 tctggattga tgtcttttcc ttttgccact gctaaggcgc tcgccactaa ttcatggtgc 3942481 gccgtttgat acatgacttc cttggcgttt tcgttttcgc caaccacaac acctgaattc 3942541 gtccatagga acagcggatt gttcacatcc atttggttgt taatctcgtt aaatgtcatc 3942601 cagtacttca ctttatcttt gtaacgggta aagcaagcct ctgcgaagtt gacgaagaag 3942661 tccacgactt tccggtttct gaagccgcca tattctcttg ccaggtgcag cggcatttca 3942721 aagtgagaca gggtaatgac cggctcgatc ccatgcttca gcaattcatc aaacacatca 3942781 tcataaaact gcaaaccagc ttcgttcggt tcagcctcat cgcctttcgg aaaaatccgg 3942841 ctccagccga tggacgtccg cagacatttt aatcccattt ccgcaaacaa agcgatatct 3942901 tccttgtatc tgtgatagaa atcaatggct tcatggtttg gataaaattc gttttcttca 3942961 atcgtgtcag tgatttttct cggcacgccg tgcgcacccg ctgtcatcac atcgacgaca 3943021 ctcggccctt taccgccttg attccatccg ccttcaaatt ggtgggcagc taaagcaccg 3943081 ccccataaaa aatcctttgg catgtttccc atgtttaatt cctcctcagc ttacgactgt 3943141 aaatattttt tgatgtaatg cactttcctc aatgtcttca atgaaagctt tatcaaactc 3943201 aacaagcact tcgccttttt tgacggtatc gccttctttt accttcaagg aaaaaggcgt 3943261 gccgtcaaat gtcaccgtat ccagcccgat gtgcgcaagc aattcgacgc cggacgctga 3943321 acgcaggcca atcgcatgct ttgtaggcgt aaccatgaca accgtaatga cgccgggatg 3943381 gtagcatcga tttcacgata tccttcgctt taggggtaga ccgcttcagc accaatcgaa 3943441 gtctggtagc gcagcgagaa gccccaatca cattctcttc cccgcctacg gcctctaaaa 3943501 tgtcttttgc tagtctcgta taatctctca ctttccccga catttcaccc accccttcgt 3943561 tttggttacg ctttcattat aattgtaacg gtataattta tcaattccga aacaaaatat 3943621 ttacgcacta actatcattg taagcggttt atgctataat tttgacaagt gaaactaaac 3943681 gaataaatga ggaatgcgta tgttaaaata ccagcaaatc gcaacggaaa ttgaaacata 3943741 tatagaagaa caccagcttc agcagggaga caaactgcca gtcctagaaa ccctcatggc 3943801 ccagtttgaa gtcagcaaaa gcaccatcac aaagtccctc gagctattag agcaaaaagg 3943861 cgcgatcttt caggtcagag gaagcggcat tttcgtcaga aaacataaac gaaaaggcta 3943921 tatcagcctt ctgtcgaatc agggatttaa aaaagatctc gaggatttca acgtcacctc 3943981 aaaagtcatc gaactggacg tgagaaagcc aacaccggaa gcggcggaaa acctgaacat 3944041 cggaatggac gaggacatct actatgtcaa aagggtccgc tacatcaacg gccagaccct 3944101 ttgctacgaa gaatcctatt acaccaaatc catcgtgacg tatttaaaca acgaaatcgt 3944161 ctcccactcc atcttccatt acatccggga aggactgggg ttgaagattg gtttttctga 3944221 tttgtttctg cacgtgggcc agcttaatga ggaagaagcg gaatatttgg gattagaggc 3944281 tggactgccg aagctgtata tagaaagtat ttttcacctg acaaatgggc agccgtttga 3944341 ttactcgaag atttcgtata attatgagca gtcgcagttt gtggtacagg ctaatagttt 3944401 tttattatag ggctcttcac tacggtaggt ggtcgacatg tacaaaatta tcattcctgc 3944461 catactagcc atctttgcgc tctggatact cttacagatt tcactagaga tgagcatcgt 3944521 taagaatcca atgaactact ttatcgtatt cattatcttt ttcctctttg taaagatggt 3944581 gaaagaaaaa caataatagt ttgggcgatg caaacagaaa aacatccttc ccttaacaaa 3944641 ctcagccagt cacatgcatt aatcttgatg ttaatgatat ataggtgcac ataaaaagct 3944701 acttcattgt gaagtagctc cctttattaa aggcccattt tgatccatct agttttagaa 3944761 aagcgaagga caatcgcatt tatgataata attgaaacta aatacaaaat aataaataaa 3944821 acatcattac tcccaagtgt catgttatca gattgcagca ctctttctat tcgggggtac 3944881 atagtgttac ctgcctcaaa aggagcaatg aaaccaaacg ttttattgct tatagctact 3944941 aagataacag aagtcatcca ataaacgata ctgacaccta tactaattaa tatattagga 3945001 cataacacgc ttatagttcc gataattaga atatactgca gtataactgc agaaaataaa 3945061 aaaagtaata atgcaaaatg cgaaaaatca tggtacatca acgatatgat tagcaggcct 3945121 agcgttataa atgcaaaaca ttctaaaaat aaaacagcta tctttttata aaagaaagta 3945181 tagatgttct ctccaattaa cttgtaaaag agaatatttt tgtttgaata ctctctatta 3945241 ataaagaaag ctataacaaa tgaaaataac atcaaaccaa actgggtcgc aacagtatag 3945301 gagctaaaga aaaacatttc aggtgtaaca ttactgactt tatcgattcc aacaagtaaa 3945361 aaataaccca gcaaaaataa aaatacaaac attgctccta aaataatgat aactttgttg 3945421 ctaatactct ttttaaactc taatttcatc tcaagccccc actgttttat tactcattta 3945481 tatacacttc aattaattta tccactgaat gatattgttg aatttcttgg tgattaaata 3945541 tataataatc cccttctatc gcctttaaat cagacaaatc atgtgtaatg ttgatgataa 3945601 tcttctcggg gttctcctga atatacttgt ttaagaagcc atgaatctct ataaccgttt 3945661 ttttgtctaa tgaattcgtt atttcatcta aaacaataat atttttatcc tctaataaga 3945721 aactgagcaa ttttaatttt tgcttttgtc catcactcaa atttttgatc agaacttttc 3945781 catcaatatt atccagatta agtaaatatg cgattttatc tatcattttt gcatcaaatt 3945841 ttttactcaa aaagtgtaat aaaaagtcct tagaaacatc attaggtata ttcgacgagc 3945901 tggatattaa agaaacattt tgacgaatat ctctgccgat tcttttgcta ttattcaaca 3945961 aaaagtcttt agcaagctgt gatttaccga ctccattttt tccgacaacg tgattaattt 3946021 tcccgctcga aaaatgcaag tcggtgtcct gaagtaacgt tttgcctttc acttttaaag 3946081 tgtaattcgc tatattcata tacatactcc taggaaatat ttgcataata ataaaatgtt 3946141 ctgccttgtg atttgttact aatgtctaag cttttgaggt acctctttcg tttccgatcc 3946201 ggaagcgaaa gaaatgtttt tagatggcta atttggagat cttttactct agtttacaat 3946261 atataatatc caatgtacaa ctgaattcac tgcaaggcca atccctataa tttgaatcgt 3946321 aagaactaac caatgatttg tcttaaaacg gctatattca tctaagctca gaaaagctaa 3946381 aagaattttg taaccatcag aattcaatat tgggattaag ttccacaata aagtagacga 3946441 gaaaagcata aatgccatag ttaatgcttc actggaaaat gtaaattgat ttattaattc 3946501 taatgtattt attaaaagat aattgataaa caagccaaat aaatgaacga ttatcttttc 3946561 atttcttgat agcatgtagg tttcattcaa ttggacataa aaagcaggaa atacataaaa 3946621 attcagtttg aatcccactt tatcaaagtt tttcccgaaa aattttaagg aataaatatg 3946681 tcccagttca tgaagcacta tattcattat aaaataaata actataatta tccacatttt 3946741 ccagccgtaa aatactgagg acaatccatt ttgcaatttt attaaatgaa tataatttaa 3946801 tatgaacatg agagccgtaa aggataagaa cagataaaaa aactttggtg atactttctc 3946861 tttatacatt ttaaaacgta ataattgttt atctgacaga gaatttaaac tatttttata 3946921 gtattctccg ctttttttgt cttttataaa tacgttgttt tgcacaagca cttcatattt 3946981 ttcatcttca tactttaaaa ttttcattat agtatttttc catataagga tagaagtagt 3947041 ttattttttc tgcagagttg aataaggaac cacaaactcc acaaatagag gaaaattcat 3947101 aaggaatgtc aaattcctct attttgttat tttcttttaa aatattcaaa aaccatttga 3947161 atccttcttt tctaagaata aataatagca aattggaatt taacttttcc acggttcttt 3947221 cgaaactttg gttatattct tcccttaggg ttattttcgt ttcaaaaata gcaggggaac 3947281 aacatggata aatttctcca tcatgatgat atacaatgtc atatccggga caatgtaagg 3947341 aatcttcatc ttcaagactg taaaatttat gtatgttttc ttgcttaatt ctagttttag 3947401 cagcgccaac tgatatcatt ggaaattttg ttatctttac acctaagatt gaatccccca 3947461 attcctctaa aatgtggttg gacattttgt ctttggtaac tgccatatta agagaaatat 3947521 cgatatcagg gtatttcctg ctatgttcta atatgttttt aatactggaa gacttgacaa 3947581 atggagcatg gtactcatca taacttatag tcagtgctat cacatttaaa gaattcatat 3947641 catgaaagta ctcctggacc tttttcttgc tcaaacccca aaatccatta gagatcaacg 3947701 ttatttgttt ttcatatggt ttaatgattt ccattagttc ttttaaaaat ttataatcta 3947761 aaaaaacttc cccacctgta aaagaaatca cttgaatggt tttgtttttt gcaaattcag 3947821 ttactaactc tcttatgtat tctttttcca tcctggttgt tgaagttggt gaactagaaa 3947881 aacaacaatg gtcacaggat gcattacacc ttgaatctaa attgattgat actgttttat 3947941 tatacatgaa atatccccca acaaatggta aaggagagtt agactctcct ttgtacccct 3948001 ctaattaatg accacttcca agaatccagc gattttcttt tgattttaca aaataccaaa 3948061 gatcattcac ttttgctaac ttttgtgatt catctaatag acccttaaat tctaagtttt 3948121 tcacagtctc attgttagtg atttcctttt tcatattatc cctcctcctt ttctaatata 3948181 aaccaattat tctatatcat tcaatacatg tcaatatatt gtacctaaaa aatctgaaaa 3948241 atgtcactat tcttggtata taaagcctat agtcctctag cccctctaag ctataccgaa 3948301 tgaaaggcca tagtttgatt taaagcttcg taatgaaaag taaaacatca atattgacta 3948361 cactagttaa gggatataca gattttaagt ggaagaaatg aggcaaacaa tcttacccta 3948421 aaccaacctg tactgaaaag ctgttttaag ctcttgctta ccccatttgg cacctctttc 3948481 tctcgtttta attgtctcta aaagcagtta tgcggtacta tcatataaag gtccaatgtt 3948541 taaaaataat gtcatacttt taaattcacc ttatcatgca catgctcata aagaggggtt 3948601 tattctaaaa aggggatgga cggttttgga aagcaagtac ctagatctac tcgcacaaaa 3948661 atacgattgt gaagaaaaag tggtaacaga aatcatcaat ttgaaagcga tattgaacct 3948721 gccaaaaggc accgagcatt ttgtcagtga tctgcacgga gagtatcagg cattccagca 3948781 cgtgttgcgc aatggttcag gacgagtcaa agagaagata cgcgacatct tcagcggtgt 3948841 catttacgat agagaaattg atgaattagc agcattggtc tattatccgg aagacaaact 3948901 gaaattaatc aaacatgact ttgatgcgaa agaagcgtta aacgagtggt ataaagaaac 3948961 gattcatcga atgattaagc tcgtttcata ttgctcctct aagtataccc gctccaaatt 3949021 acgcaaagca ctgcctgccc aatttgctta tattacggag gagctgttat acaaaacaga 3949081 acaagctggc aacaaggagc aatattactc cgaaatcatt gatcagatca ttgaacttgg 3949141 ccaagccgat aagctgatca ccggccttgc ttacagcgtt cagcgattgg tggtcgacca 3949201 tctgcatgtg gtcggcgata tttatgaccg cggcccgcag ccggatagaa ttatggaaga 3949261 actgatcaac tatcattctg tcgatattca gtggggaaat cacgatgtcc tttggatcgg 3949321 cgcctattcc ggttccaaag tgtgcctggc caatattatc cgcatctgtg cccgctacga 3949381 caacctggat attattgagg acgtgtacgg catcaacctg agaccgctgc tgaacctggc 3949441 cgaaaaatat tatgatgata atccagcgtt ccgtccaaaa gcagacgaaa acaggccaga 3949501 ggatgagatt aagcaaatca caaaaatcca tcaagcgatt gccatgatcc aattcaagct 3949561 tgagagcccg attatcaaga gacggccgaa ctttaatatg gaagagcggc tgttattaga 3949621 gaaaatagac tatgacaaaa atgaaatcac gctgaacgga aaaacatatc aactggaaaa 3949681 cacctgcttt gcgacgatta atccggagca gccagatcag ctattagaag aagaagcaga 3949741 agtcatagac aagctgctat tctctgtcca gcattccgaa aagctgggcc gccatatgaa 3949801 ttttatgatg aaaaaaggca gcctttattt aaaatataac ggcaacctgt tgattcacgg 3949861 ctgtattcca gttgatgaaa acggcaatat ggaaacgatg atgattgagg ataaaccgta 3949921 tgcgggccgt gagctgctcg atgtatttga acgattcttg cgggaagcct ttgcccaccc 3949981 ggaagaaacc gatgacctgg cgacagatat ggcttggtat ttatggacag gcgaatactc 3950041 ctccctcttc ggaaaacgcg ccatgacgac atttgagcgc tatttcatca aagagaagga 3950101 aacgcataaa gagaagaaaa acccgtatta ttatttacga gaagacgagg caacctgccg 3950161 aaacatcctg gcagaattcg gcctcaatcc agatcacggc catatcatca acggccatac 3950221 acctgtaaaa gaaatcgaag gagaagaccc aatcaaagca aacggaaaaa tgatcgtcat 3950281 cgacggcggc ttctccaaag cctaccaatc cacaacaggc atcgccggct acacgctgct 3950341 atacaactcc tacggcatgc agctcgtcgc ccataaacac ttcaattcca aggcagaagt 3950401 cctaagcacc ggaaccgacg tcttaacggt caaacgatta gtggacaaag agcttgagcg 3950461 gaagaaagtg aaggaaacga atgtgggtga ggaattgttg caggaagttg cgattttaga 3950521 gagtttgcgg gagtatcggt atatgaagtg aggggtgtgg ggttcaggga tggtgatatg 3950581 ctgctcccct aaaagtagat agatgaattt tagaaaatct gtttgccttg gggagttttt 3950641 tcatggctgg acaattatac tacaaggaag aaatactaat acttatagaa tgtaattggg 3950701 taatgattcg gagaaagagg ttgcgaaata atatggtatt acactgaaac aattatcaat 3950761 ggagaacatg cacgatatag ccgttctata ttctccctct attatggcac tcattagtag 3950821 acataaccgt aaaaaaatgc actcaaaaaa agtccattct atataactct cgctagggtg 3950881 gacctttttc aacattcaaa gtactagatt ttttctagtg aaagaataag aaaagacata 3950941 agttctattt tatcactctg ttataggtta agttattacg gtgtttcatt atatactgaa 3951001 tttaaacacc cttgacatta tgggaatttt taaaacaggt taaaaggaag ttctataaga 3951061 actccctagt ttaatattat ttggtcaaaa tctaaaacca aaaaatctat ttttatcttc 3951121 attgtttcta tctaattttg caacaatcat acctttcgac tctaattctt gaaggtcatc 3951181 taataataat tcatttttat ttattgttac aaaatattgt ccgatcctat tctctaacag 3951241 acttgaattg atatgtttta ataatgtacc ttttacatga ggatcaggat tagaataaga 3951301 tccgtcatga attaaaatat tcaaactaca cttatttata cacctgtata aaaaccaagt 3951361 aagatcaaat atatttatct tcatatggag tctaccatgt gaacgttcat ccggtataga 3951421 acaagaaatt ttgatccttc ctgtagttga ttgttttgcg ttacttattc tattatcata 3951481 ttcaaaatct aaaaatccat gttggttgta tgtaacatcc attagattat taaaaagctt 3951541 ctttaactca ctaactatag cgctataaga ttgaaactca tcataataca ttgaattaac 3951601 tcttaatatt tcatgttgaa gttcattaat cttatcaaaa atatggtttt ttttatcgta 3951661 gtcactaatt ctcaatctta cttccgctaa ctctatttct ttccttcttt gttcttccat 3951721 cacaatggaa atatcctcaa tgaaattgtt actctttaaa attctggcac ttgattccag 3951781 ttgttctgtt aatccttgct ttttgatatt aagttttttt aaatcggctt gtattttaac 3951841 aattttatct ttaaaataac tccctctact ttctaccatg aaattataga actcttggac 3951901 tttattataa ttctgtttta cttcctctgg aaaaaaacct acaatatctt catagaattt 3951961 ttctatattt tctaattctt taatcttagt tactttttta tttaaatcat ctatatttct 3952021 ttgatattgt ttacaaatat gttcattttc aaatatttca ttttgtattt tattaagttc 3952081 acttttaatt tctgagtacc tatttgtatc attattatat ttattggcag tcttagtttg 3952141 atagataact ctattgtaat cctctatctc atttattaat tcatcttcct taacttttaa 3952201 atcgccaatg ttaatattca ttgattcaat caattttatt tcactattta atttttcaat 3952261 cttatcccga aaaaccttta tgtttttttc tgtatgagtt ggtaaagtaa aaagatagtt 3952321 aagtaattta tattgtttta accctcccct attcggtaaa actatatcat taaaccctgt 3952381 cttttcgtct cttataatat actcccttaa cgccgcaaaa gttatatcct ctttctcacc 3952441 ctttaaaatt tccttttcaa taaatttttt atatacactt atactaactt ttttccattc 3952501 ctccaaatta aaagttaaag aagtatcatg taatgtataa ccatgtttag gagaattaaa 3952561 agatctagca aggaatactt gatttccatc aatttccaca ttcaaaacaa taaaaacgtt 3952621 tttattgaga agaatttcat ttgtcgtata aaaatttgat atagtcttcc ctagtaaaaa 3952681 ggagatgcat tcaatcatcg ttgacttacc tacaccatta gtctcttcat gatcttctct 3952741 cttttcacca agtattatat ttactcctac agcattaaat ttatactctt tcaaaatttc 3952801 ttgggaattg caaacaaaaa gattttttat aatcataaca atcactaact ctccgttctg 3952861 ctaatcatat tttgattaaa agaaacttta cctaatgaat ataaaaaagt taacgataaa 3952921 tacagtatcc gttcaatatt caaatttatt ataatacctt gactcttagc ataatcaaga 3952981 aaaagttgat caatatgttt ttccttctct aacagttcat aaagtatctt tgatgagtat 3953041 aaaatatttt cttccacagc attatattta gttaataaaa aatgattcat ttctggcctc 3953101 tccgcctttt ccttttttaa aggagaatta ttcactagag gaataagatc atttccaatt 3953161 tgaatgtttt taaactcatt ttctaataaa acataagagt atttgagaat attttcagct 3953221 gtttcaattt taagatcaat cattcttaac acttcttttg ttatcattaa aaatctcaca 3953281 ttcataaatg caccaacatg ttaaaatctt aatgtatttt ttcgttaaag cctttgaata 3953341 tggtaaaact gaatgacatt ctagataaat ctcattaaca atttttacaa atatctcatc 3953401 tccattatta tattgattat gaaactctag atatttgtct actatcgtct cagcaatcaa 3953461 ttccttttta tcagcactta catacgaagt ggaatccatt atatggttta tcacaccaaa 3953521 atactcagaa taactatcga atttccgttt aaaagtttcc ccacttttca tatcataaaa 3953581 ttttttatct aaaccaattt gattatcaaa attactagta aatgttttat aactttctct 3953641 atactcatga aaatctataa taaagctctt aaactcatct tcatcaattt tatcatcgtt 3953701 atcttctatt tctttttcaa taaggctctc taatctatta atcttataat ttaacttccc 3953761 ttcctgtagt ctccttcctc cttggttgtt ttttgaccag tatttatatt cggtattcca 3953821 aatgtagtat gttacttctg tctcgccatt atctaaattc acatccaccg aaataaattc 3953881 tggagtagca tactcatcct ttataatggc tccacttact aattctaaga atggattttc 3953941 atttgtattt gcagtaatat taaatgaaga atcatgtaca tgtcctgcca aatatagatc 3954001 aataaagtaa tcatcaaaat gtgcctttat tgattctctt tcggaagatt caatacaacc 3954061 taacgtatgg tgcccaatag ctatatttaa taccttgccc ttatttttct ctttgttcat 3954121 cttccttatt gctttatata atttcatctg tgcagttaat aacgttcctt cttcaccttt 3954181 tttatctgat aacagacatg tatttattga taaaacatta tacttctccg attgatacaa 3954241 aaaatgcaaa tcttcttccg gatatttaac acccataaaa tcttcataaa aatcgaaaaa 3954301 tttcctttga ccttccacta atatatttgt agctttttga tctagtttat ccaacatttc 3954361 tgaggggtta ggagatttca taatactatc aatcaaaagt gtcctcgtca tgtctctaga 3954421 tatatcgtga tttcctggca ctaagtgtac gttattctta cttaatccca tacttttaat 3954481 aattccatta agatattctt taacatcttc gttatacaca tcacctttgt gtgctatatc 3954541 tccagttaat aataaaaaat caaaatctga ctctcttctt aaaacttcta taaaatctaa 3954601 taatttatct ctcattacaa tagtgtcata attttgaaac tgaaaatgca aatcagaaat 3954661 ttgtaaaaaa cgtaccttca atacaaacat cctctcataa gtatatttat cccctatata 3954721 tttctagaaa actttttatt ctatatcatc tttactcttt aatatattaa gactctttcc 3954781 acaccatcaa ataaattata acctaaacat aactctttac tcattttagt attgtattta 3954841 agtcaaacat tgcattggtt gctgaaatat tatattcatt gaattattcc attaaatagc 3954901 ttttagttga actttagtct ttctgtaatg gtggagatgc tcttacttat gataaggctc 3954961 cccacgatta atccgaaaag cccgataaat ctgctccact aaaataagcc gcatcaactg 3955021 atgaggaaat gtcatcttcg agaacgatag cttctcgtcc gctcgcttca tcaccgtgtc 3955081 actcaatccg agtgatccgc cgatgacgaa ggtgactttg ctttttccat aagtagccag 3955141 cttatctatt gtatcggcta gttcttcgga tgttttcatt tttccttcga tggcgagggc 3955201 gatgacgtgg gcgtcggggc tgattttgga taggatgcgg tcgccttctt tgtcttttat 3955261 gattttcatg tcctggtcgc ttaggttttc cggcgctttt tcgtccggga gttcgatgat 3955321 gtcgattttt gcgtaggccg aaagtcgttt ggtgtattct tcaatgcctt gcttgaggta 3955381 tttttctttt agttttccga ttgtcacaat attgatattc acaggtcatc cccactttaa 3955441 aaacaagtta ttcatatatg ttgtccacaa ttgtggatat cttttctgta ttttgtgtaa 3955501 gatcattcgt tccccactat atatactgcg gggtctccac ataattcaca ggctgtggat 3955561 aaactgttag tatgttcgat ttttctgatt tcgggcggca gctcgtggtc gtctatgtac 3955621 atatccagca ccgtttcgat gtgttcttca caagaataat acgcttgttt catgttcaaa 3955681 tcctccgatg ttttcttcca tttttacaaa tgttctcttc tcaatataac ctatttattc 3955741 acatgttagt agtgcttcgg gctgagtttt atccacaatt cgacaaacaa gctgttgatg 3955801 actctatttc gctcgtgtgt tagtttggat gtaaccgatg tgtggggagg tctgcatttg 3955861 cgctttagat gggtttggct ttttgtgatt atgttgctgc ttgctgagtg tcagccatct 3955921 tattgggtgt tggagaagga tcgaatcggt gaaggcagtc cagacttaga aatatacgct 3955981 aattatctcc aaatgcatga tgacgtgaaa ggatatcaag tcttcaccat atcagaaggc 3956041 aaaaaaatgg tcgtcgtgtc tctcggaagc agcgagaaag ataagaagct tgaagtgtcg 3956101 gacgtcaaat tctcatctaa agaaacgatt gtaactgtgg agcgaaaacc tgctcctacg 3956161 gcaaatgaga aaaacccttt tattttgatt ggactggaca aaattgaagg ggatttaatt 3956221 gttcaagacg aaacaggaga tcgctttgaa gaaacggatt accagcaata aagccggcgt 3956281 tctgagaacg tccggctttt tcttttactt caatgtccca tgcgggtcga tgacgaattt 3956341 tttggctgcg cctttgtcga agtcgctgta gccttttggc gcgtcgtcca gagaaataac 3956401 ggtggcattg acggcttttg cgatctgcgc tctgccgctc aggatcgctt tcatcaaatt 3956461 gcggttgtat gtcatggcgg gcgtttgtcc ggtgacgaag gtgtgggctt tggcccagcc 3956521 gagtccgaag cggattttta atgagcctgt tttggcgtcc gcatcctttg caccgggatc 3956581 ttcggtcacg tataagcctg gaatgccaag gctgcctccg acctgggtga cgtccatgat 3956641 tgagttcagc acggcggctg gcgcttctcc ttgattgccg tgcccagatg cttcaaagcc 3956701 gacacagtcc actgcagcat caacggttgg ttcacctagt atttgttcaa tttgctcgcc 3956761 gaggcggtcg tgtttttgca cgttgaccgt ttcacagccg aagcttctgg cctgtgccag 3956821 cctgtcttcg ttcagatcgc cgacaatcac ggtagaggcg cctaggagct gagcggagtg 3956881 tgcagctgcc aagccgacag gacccgctcc agcgatataa acggttgaac ctgtttgcac 3956941 gcccgctgta taagctccat ggaagccggt cggaaaaatg tcggacagca tggtcaaatc 3957001 gagaatcttt tctagcgcct gttctttatc agggaatacc aaaagctgaa aatcagcgta 3957061 tggcaccatg acatattcag actggccgcc gacccagccg cccatatcga cgtagccgta 3957121 agccgatccc ggccggtccg gattgacatt caggcacaca tgcgttttct gcgttttgca 3957181 catcacacag cgtccgcagg caatattgaa aggaacggat acgatatctc cttttttgat 3957241 aaattcaaca tcacgccccg tttcaatgac ttctcccgta atttcatgcc cgagcaccaa 3957301 gccttctggc gccgttgtgc ggcctctgac catatgctgg tcgcttccgc aaatgttggt 3957361 tgtaatgact ttgagaataa ccccatgctc acattttcga ttcacattcg ccttcgggac 3957421 gccgggcccg tccctcaaga ttaactccgg ataaccgata tcctccaccg ctacagtccc 3957481 tttgcctttg tacacaaccg ctttgtttcc tgtcaacgcc attcctccca ttcatgtgtt 3957541 tggactctcc gtccttgaac atgacttcgg ttcggcatga ctctttccct ttttcacgac 3957601 tgttttttct gtattcttac aacaacaaat atgccaagaa agcatccaat aatggttccg 3957661 ccgatgtcta agaagtcgac tttacatcca tttaacaaga acacagtaat ggccgaaacc 3957721 aggcagatca taactgccag aagaataacc cgatttgtct gcatgtaatt cctcctttgg 3957781 attcgtttct aaaccatacc caaaatcctc tgcaaacttc ggttcaacaa aaaaagagac 3957841 ttcacaccag tctcttcata aacagagatc actcaaaaaa tttcctgaga aataatgtgg 3957901 caacactcgt tactaacgca attgccgtat acataacaac ccaaaatatg aatgagctat 3957961 tccccgaagc taacgtaact aacaatatca agctcgtgat aagaacgatg agcggtgcca 3958021 cccaaaatct tttaaataaa aaatgacccg ctataccaaa tacacctgcg acgatcggaa 3958081 aaccaaaaac gataaataaa acggcgatgg ctcccatact accctccttg ccttaaaacc 3958141 tcttcatcac ctcaacatca tacagcttca aatgactctt cggcgtcacg acatccttta 3958201 ccttcccaat ctctttttct ttcattttct ttccggtttt caggctgtac tgttcaatgt 3958261 aggcaggctt gtgatacgtg tatgtgaaga aatagaggct gctgcctttt tgggtgattt 3958321 ctttgaattc ggctttcatt ttgtccgggg aaagggtgaa gacgatgctt gtttttcctg 3958381 tcttggcatc gattttgtgt acctttccga agccgtcaat gaaatacagg ttcccgtcat 3958441 aagggaaaaa gctgttttta aagctgaagg gcatggagct gtatatcgtt tgttcgtcgt 3958501 ttttgtattc ggcgatatcg tgcagctcta cttcgccgct ttttttgttg atcttgacca 3958561 tttgatagag atcgtgggct ttttggccgc gaaccataac atacacagct tggtcgtcca 3958621 cggcaagttg ggattcgact gaggctcctt cccggtactg ccattccgtt atgctgagat 3958681 aggtaagctt cttctgatct gcttgaatct gaaggagctg atagcctttt ccgtcatctg 3958741 tcgggacgag tgcgtaaatg gcgccatcat ggaaaccgga ggctcggatg tagtagggga 3958801 tgacgtcttt tttccactct ccgtccattt ggcggtacag ctctgagcgg tatccgtctc 3958861 cctttttgtc gtagccggag ttgtataagg tgtaaaagcc gtccgtgttt tgcagaaagc 3958921 ccgcgctgtc gcctgtgtgc tgataggttc ttttatggga gcgcaggccg tttttgatcg 3958981 tataaatcgt gtttttgtcc tccagcatca cgctgtcacc gtgaaccttt gctgagccca 3959041 gctcaaggcc cttcatctga aaggaagaca gcgtcccgtc atggctgata aacagggcgt 3959101 agcttttccc gccgccaaat gcatcttgat ccgcagagga tgagaaatac agcaggactt 3959161 ctttgtcatc caggaaatcg ggatttctga gatcctgctg actcacggtt ttatggcttt 3959221 tgagaggaga aatgaagaca aatagtgcga ttcctgcgag aatcagcatg gcgatggtaa 3959281 tcatccactt tttcatagcc ttctccttag taaatggtca taatggttgt cgtataagaa 3959341 gaactagtga tgtcgcgcgg atacacgcct aagcctccgt tgctgtctat atcaatccct 3959401 gctttcagca aaaaggcaga ccataggagc tttgaacagt ttttggcgcc gtcatggccg 3959461 gtatttctgt tattgacgaa gttaaatgag tatgggtcgc cgacttttga taccgcccag 3959521 tcggcagcag ctgttttttg agatgaggat acgctgacgg tttgcacaat ggagttgtct 3959581 tccacgtctc tggcattata cgcgatctgc ctgacgccgt cgctcgggac agattcaaca 3959641 attttgtcag cggcggagta catgccgaca tggccgtgat tgtagtaggc tgtgtaggag 3959701 ttcgtgtaat agatattgcc tttcgcgctt gtcgggagtt ttttcgtgcc ggacgagccg 3959761 cccatgatag acatgccgct ttccttggcg agccggtccc cctctgcttt atcagccgtg 3959821 atctccttat agaactgttt taggataacg tcctgcttta cgtgctgctg tttggcaatc 3959881 tggctggcag atttcatgat ttcttccggt gtcgtgcctg gctgcagtgc ggcgatttct 3959941 tcagcataat ttgtggtctt tacggctttg gcgggagtaa caaacaggcc gccgcacatt 3960001 gtgagcgcta ccaaaaacat cgacactcgt ttcttcaact tcattacatc tcctcttttc 3960061 ttgtgagtgt aggaaaggta atttcctcac ccacattata ttaggaaaat aaggaaagta 3960121 actaggttat ttacagaatt tttagaaatc gtttacagaa aaaggccttt atcaggccct 3960181 tttcgttaaa gcttcttgct catcactacg tctgtttctt gaaatccggt ttgctcatat 3960241 agctttcgag ccgtctgatt atgggcaaag acatgaaggg acagcttgcg gattcccata 3960301 ctgcgtgccg cttgatctaa tgccgccaat gcttgctttg cgtagccctt tccccgatac 3960361 ggttcatata acccgaaatc ataaataaac gcttcctgct gcggatgctc cggttcagca 3960421 tgtatccaga gccagccaac gatatccttt tcattcagct tgaggctcca caaatggtga 3960481 tggggtgttt cgagccctct cggaagcaga tcagtaaaca cctgcttaga caaaagctgg 3960541 gcatcttcag gcagccatgt tcccgctttt accttttctt ccgcgtaatg ctttgttgtg 3960601 tacgtgagat aagaccgaaa ttcttctgtc tgcatagggg ttagcataat tgtcatatca 3960661 tctctccttc atatattgac tagaggattt tacataaaat agaaagaggt gttactatca 3960721 gaataagcaa ctgagattga taagtcacta gagaaaggag tttcacatga ataagatcgc 3960781 acccgcagaa atcgctagca tgctcaacga ttggtacctt gccatcaaga aacatgaagt 3960841 tgaagaatcc tcccgtttat ttgaagaagt gaagccttta ttggatgaca tggaagagga 3960901 tcaggaggtg cttgcctact tctccttatt ggaactgcgc cacaaggttt tgcttcacga 3960961 ggcgagagga cagggctttc agcatgagga gccttctcat atgaatgcta cgtctgacat 3961021 gctgaaatat tacttttttc tgtttgaagg catgtatgag gcctataaaa ataattatga 3961081 cattgccatt gggctgtata aagatgcaga gcagtatctc gacaacattc ccgatccgat 3961141 tgaaaaagcc gaatttcacc tgaaggtcgg taagctctat tataagctgg gacaaaatat 3961201 tgtgtccctc aatcatacac ggcaagcagt caaaacattc agagaagaga cagattataa 3961261 aaagaagctg gcttcagccc tgattaccat gtcaggcaat tttacagaga tgagccagtt 3961321 tgaagaagct gaggcttatt tggacgaagc aattcggatc acgagtgaat tagaggatca 3961381 tttttttgaa gcccagcttt tgcataactt cggccttcta catgcgcaaa gcggcaaatc 3961441 agaagaagcg gtttcgaaat tagaggaggc tctacagaac gatgagtatg cccgctccgc 3961501 ctattattat cattctgcct acttgctgat acgagagctg tttaagatca aaaagaaaga 3961561 acaggcctta tcttattacc aagacgtgaa ggaaaaattg actgctgagc cgaatagaat 3961621 atgtgaggca aaaatagaca ttttatatgc catttatgca gaagggggtc atgcggaaac 3961681 gtttcactta tgcaaacaac atatggatga cttgttgtcc gagaaagagt atgacagtgt 3961741 aagagaactt tccattttgg ctggcgaacg gtatagggaa cttgagcttt acaaagaagc 3961801 tgcccacttt ttttatgaag cattacagat tgaagaactg attaaacgaa cggaggttat 3961861 ataaatgaaa agatttctga ttggcgcagg cgtcgcagcg gtgattttat caggttggtt 3961921 tattgcggac catcaaaccc actcacagga aatgaaagtc gctgagaaaa tgattggata 3961981 aatgaaaaac ccccgcggga tgcgggggtt caatttaacg aaagaatcct aaaacggttt 3962041 gtagttttag gattctttca tcttttcagc gtgattgaaa acccttgaag tctaggaaga 3962101 acgagcattg gagcgcagcg aatgtttgga attcgtgagc accgaagcgc aggcctgaca 3962161 acgaatgcga gggtttgtcg acacgctgaa acccccgcgg gtgcgggggt tttcttatta 3962221 cagcagcttc ttccctaaca gggattctac gagctctact gctgttttgc ccgttttgtt 3962281 tttgtgatca aggatcgggt taacctcaac gaattcggct gaggtaatga tgcctgcgtc 3962341 atacagcatt tccatagcca aatggctctc ccggtagctg atgccgccga cgacaggggt 3962401 tccgacaccc ggtgcgtcgt tcggatcaag tccgtccaga tcaaggctca gatggacgcc 3962461 atcacatgct gataaataat caagggtttc ttcaatgacc tttgtcatgc caagacgatc 3962521 gatttcgtgc attgtgtaca ccttcatgcc gctttcctta atgtacttgc gctccccttc 3962581 atcaagtgac cgggcgccaa tgatgacgac gttttccggt ttgattttag gcgcgtagcc 3962641 ttcaaggtta accagtgact cgtggccaat gcctaggctg accgcgagcg gcatgccgtg 3962701 aatattgccc gatggtgaag tttcaagtgt attcaaatcg ccgtgcgcgt cataccagat 3962761 gacgccgaga ttatcgtaat gcttcgctgt gcctgcaagc gtgccgatcg caatactgtg 3962821 gtcaccgccc aggacaagcg ggaatttttt ctcttcaatg actttgttga ccttttgcgc 3962881 gagtttttca tttcccgcca aaacggaatt caggtttttc agttcctcgt catttttgat 3962941 tttttcgcga ttgatcggaa tgtcaccgag atcttcaacc gtatacccca tgtctgacag 3963001 cctctcgatc agatgagcgt accggatggc actcgggccc atatccactc cgcgtcgtgc 3963061 ttgtcctaaa tccattggca ttccaataac cgaaatcgtt ttatccatct gtgattccac 3963121 ctcaacattt aagataatgt cctatgcggg ttataacaaa gatgacttgc ggacaacgtt 3963181 tttaaagctc tagctgacga tttgcctgct ggcgtttttt aatgacgaca tgataaatga 3963241 tgtagcaaat gatcataaac ggtacgccgc aatacagcgc gatacgctgc tccggatcaa 3963301 atgcaagact gatgagcacg accgtattta acgttaggcc gatcagcgga agcaccgggt 3963361 acagcggtgt tttaaatttc aaatcttcta tcttcccgcc ctcacggata tatttgcgtc 3963421 tgaacatgat ttgggaaagc gagatcgtaa tccagccgac ctgcgcgctc atgcccgcca 3963481 aagataacag taccatatat acggtttcag cctgcgcaaa ctttgtcaga agtgataggc 3963541 aggccacagc catcgttacg attaacgagt acatcggtac accgcgctga tttgttttgc 3963601 caagcgcttt gaaggcttgt ccttcattcg ccatcgcgta cagaatacgt gttgatgcgt 3963661 ataaacctga gttcgcaaca gataacagtg cgattaaaat aacaaagttc atgatatcag 3963721 ctgcatatgg gattccgatt tgctcaaata cggcaacaaa tggactttcc acgacacccg 3963781 cctgtttcca cggaatcatg ccggcaatga caatgattga aagcacaaag aacacaagcg 3963841 ttctccatac tgtctgtttg atggaccgcg gaatcgtttt ttcagggtct tcactttctc 3963901 cggctgcaac cccgatcagc tcagtcccct gaaacgcaaa gttcacagta atcatcgtaa 3963961 tcagcattgc ctttatgccg ttcggaaata acccgtcttc ataaaaatgt gtcaaaaacg 3964021 gcgcctgctc tccgcccttc agatcaatca ggccaaacat ggcagctccg ccgagaataa 3964081 taaataaaag gataatcaaa attttaatgc ctgagaacca gaattcagat tccgcaaagg 3964141 cttttgtggt gatcgcattt aaaataaaca tcagtgccgc aaagaccaga caccagatcc 3964201 acacgtctat atgcggaaac cagcgttgca tcagctgccc cgctgataaa aattcaatgg 3964261 cgcatgtaac cgcccagccg agccagtaca gccagccgaa cgcaaacccg aaggccgggc 3964321 tgataaattt cgtggcatag gtctggaagg accccgacac aggaaaggcg actgccagct 3964381 ctcctaagca gagcatggtc aaaaacatga taaagccgcc cactaaatag gacagaaccg 3964441 cgccgagcgg tcccgcttgg ttaatggtaa acccggttcc aaggaagaaa ccggttccga 3964501 tcactccgcc caatgaaatc atgaacaaat ggcgtgattt cattgtccgc tggagctgat 3964561 ttccgttatc ttggtttgta ttcacattct gcaccccttc agcaacttgt attggatcta 3964621 agctggaaca tctgcatggt gctatcccag tttgctgtcc aaagagtctc tatctattta 3964681 atataaaatt cacttcttct cataaagata cattatacta aaatactgta gctgagcaaa 3964741 tagggagtgc tgatttttct gttgtaaatt tatacaaacg aagtgaatat cccgccatgg 3964801 tgcggattta tgcgtttcgc agcacgtgct taattttctc tatcgcccaa tccaagtcct 3964861 ctttggaaat gattaatggc ggtgcaaaac gaatgactgt atcatgcgtt tccttgcata 3964921 aaagtccctc ttccttcaaa cgctcacaat acggacgtgc cgcttcagtc aattccacac 3964981 cgataaacag ccctctgccg cggacttctt taatgacagg gctgtcaata ctctcaagct 3965041 cgcttttaaa gtattcacca agttcaagag aacgatccgc cagcttttca tcctccagca 3965101 cttctaatga agcgatagac actgcacatg caagcgggtt tccaccaaat gttgagccgt 3965161 gtgagccagg gttaaacacg cctaggatct cgcggtccgc cgcaatgcaa gagatcggga 3965221 acacaccgcc gccaagcgct ttgcccaaga tatacatatc cggaacaatg ccgtcccagt 3965281 cacaggcaaa cgtcttgcct gtacgtccga gacccgtctg aatttcatcc gcaataaaca 3965341 agacattctc ttccttacaa atcgccgccg cttcctgtaa aaatccttca ggcggaatca 3965401 caatgcccgc ttcgccttga atcggttcaa acaagaatgc cgctgtattc ggcgtaatgg 3965461 cctgtcgaag cgcttccaca tcgccgtaag gaatgagttt gattcctgga agcatcgggc 3965521 cgaatcctcg tttatattcc tcttcagaag aaagagatac cgccagcatc gtgcggccgt 3965581 ggaagttccc gacacatgcg ataatttccg cttgattgtc agctacgccc ttcacttcat 3965641 acgcccagcg tctcgccgct ttcaccgcgg attcaaccgc ttcggctcct gtattcatcg 3965701 gcagaatcat ctctttgcct gtcagtttag ctgttttttc gtaaaacggc ccaagctgat 3965761 cgttatgaaa cgcgcgtgac gtgagggtga ttttatcagc ctgatccttt aatgcctgaa 3965821 tgattttcgg gtgtctgtgc ccctggttta ccgcagagta agcactcagc atatccatat 3965881 attcattgcc ttccgggtcc tttacccaag cacccagcgc ttcagaaata acaatcggga 3965941 gcgggtgata attgttggct ccgtaatgag acgtctgatc aataatttct ttggatttag 3966001 ataaagctgt catatttgaa ttcccccttg ttttctgttt caacatgtta tcctgctttc 3966061 cctttatata aatgcaagtt ctgtgccaaa tcaagaattc gtgtgttttc tacaattttc 3966121 gaggacaagg tgcaaaaaca ttctgatatt tcgagcgaaa atttcagcaa gtgcaaaatt 3966181 cttttgcata tcctctccgt ttttttataa aatagaagca atattaagaa aataattgag 3966241 ggaggttcat acagtggtca aagacagcga attcctcaca ttggtttttc agagtatttt 3966301 agatgaaatc gatgttggcc tgcacgtggt agacgagcat ggaaacacaa tcgtttataa 3966361 caataaaatg atgcagattg aagatatgga gaagcatgac gtcttgaata aaaacctgat 3966421 ggatgtgttt atgttttcaa agcagcagga cagcacactg gtacaggctc ttcaggaagg 3966481 caagacgatt aaaaacgtca aacagagcta tttcaataat aaaggccagg aaattacgac 3966541 gatcaatcat acatatccca tcgtccaaga cggcaaaatc aggggcgccg ttgaaattgc 3966601 caaggatgtg acaaagctgg aacggctgat cagggagaat atgaacaaaa aaggcagcac 3966661 aacctatacg tttgacagta ttctcggcac cagtccggcc attcaagacg tcatcgaaaa 3966721 cgccaagcgg gcaacccgta cgtcatcatc tgtccttcta gcaggcgaaa ccggcacggg 3966781 aaaagaactg ttcgcgcaaa gtatccataa tggaagcgat cgttctggcg gcccgtttat 3966841 ttcgcaaaac tgcgcggcac tgccagacag ccttgtggaa agcattttgt ttgggacgaa 3966901 aaaaggcgcg tttaccggcg ctgtcgacca gcccggcctg tttgaacaag cccacggcgg 3966961 cacactgctg ttagatgaaa tcaactcgct gaatctcagc cttcaggcga agctgctgcg 3967021 cgcccttcaa gaacggaaaa tcaggcgcat cggttcaaca aaggatacac cgattgacgt 3967081 acgtattatt gccacgatga atgaagaccc aattgatgca attgcaggcg aacgaatgcg 3967141 gaaggacttg tattacaggc tgagtgtcgt cacactgatc atcccgccgc ttcgggaacg 3967201 aaaagaagac attttgcttc tcgcgtcgga gttcatccag aaaaacaacc atctgttcca 3967261 aatgaatgtt gaacacatca gcgatgacgt gaagcaattt ttcctttctt atgactggcc 3967321 gggaaatatt cgcgagcttg agcatatgat cgaaggcgca atgaatttca tgacggacga 3967381 gcaaacgatt acggcttccc atctgcccta tcaataccgc atgaaaatca agccggctga 3967441 catcccagag ccggaaacac caagacacca gccagccgcg gacttaaaag aaaaaatgga 3967501 aagcttcgaa aaatatgtga tagagaacgt gttaagaaaa cacggccata acatctcgaa 3967561 agctgctcag gagcttggca tcagcagaca aagcctccaa tatcggctga agaaattttc 3967621 tcactcgtct aacgaataat ccggagcagg aagcctgatc agaaaaacag tgcctctgcc 3967681 gatttcactt ttcacttcaa tcgtcccatt gtgattgtcg ataatcgatt tcgttatggc 3967741 aaggcctaat cccgaacctc catatttccg ggagcgggat gggtctgcct tgtaaaaccg 3967801 gtcaaacact aaaaaacgtc acttcttatg cattgaagaa agaaaatggc acctatgtgt 3967861 atcacagcca gcaaccacac ggtacaaacc attaaagtcc atgcaaataa cggaagtatt 3967921 tgcagctaac tgccatttgc tgtttcacgt gtaacatcca tcttgtattt ttcttcatat 3967981 tcgatatatc ctttttcaac tgaacgggcg tgacccctgt tcagtttttt ttgcatatca 3968041 aaacagcctg gcaacgatgc cagactgctt ttattaactg cctaattggt ctgcggagga 3968101 cagcttgata tcaacagatt tttcttttcc gccgcgataa aacttcacct tcacccggtc 3968161 accgactttt ttctgataaa gccgttttcg caggtcaaca atatcattta ctttgtatcc 3968221 gtcaaattcc gtgatgacat ccagttcctt cagccccgct tttccggcag gtgaaaaggc 3968281 gtctacaccc atcacaaccg ctccattggt gacgttctta ggaagcttta atgtttcatc 3968341 ccaatgatag cttgcgatgt cacttagcga tttcatctca atgccaagga acgggcgttt 3968401 gacctttccg tatctctcta aatcctctat cacagggatc acgagcttag acggaatgga 3968461 caggccaatc ccttcaaccg ctgactcggc aattttcatt gaattgatgc caatgacctt 3968521 cccatccata tttaacaaag cgccgccgct gttcccaggg ttaatggccg catctgtttg 3968581 caggacttca gcgttccagt caggctgtcc atcaccgttt gaatctactg ggatcgccct 3968641 ctccgtaccc gagatgacgc cttgtgtgac agagcctgca aactcaaggc ctaacgggtt 3968701 cccgatcgca ataaccggct ccccagactt cactttatct gaatttccga aatcagcgac 3968761 tgctttaatc ttatcgcttt tcacccgtaa aacggcaagg tccatcagct ggtcgctgcc 3968821 gacaagatca gctgatacac gtgagccgtc tttcaagctg atttcaattt gggaagcgcc 3968881 ttcgatgaca tgatggttgg tcacgacata agcggaatgg tcatttttct tatagatgac 3968941 gccagagccg ctcccagcct cgccgctctc tccccaaata tctgattttt ggatgttcac 3969001 aacaccgaca acggcgggcg acatattgct gacaatcttg gtgacggcat tgttgacact 3969061 gacattcacc gtcctgattg attcccggcc attgttgttt tgctgctgat ctaaggcgcc 3969121 tgtatccagc ccttcatttg aaaggtacgg catgataaac gccattaata cggcaccgac 3969181 aatcacgcca atcagactcg aaagaaaata tccttttttg cttctctttg gctgttcagg 3969241 agtagtatgt tcttcctcac gttcgtaatc caccatattc catcctttcc aagaacgtta 3969301 atatggttat attgtgggtt agaaactcct agaatagtca tgatttacat agaaaaatta 3969361 tacagcgcaa agcggagtgg ccttcttcgg atcggtgtcg tataagtcaa atgtctcacc 3969421 cgtcacaaat cctttagaag ccaatgtctg ctgcacagac attcttgcca gctccttcat 3969481 gttgttgtcc tggctcaaat gcgccaggta aatacgagac gtctcatcgc caatgacatc 3969541 cgtcatcgcc aaggcagcat cttcatttga cacgtgcccg acgtcactta aaatccgccg 3969601 cttaatgctc catgggtatc ttcccatttg cagcataccg acatcgtgat tgctttcaaa 3969661 cacaaataca ttcgctgaac ggataatgcc tttcatccgg tcgctgacat atcccgtatc 3969721 tgtcattaac gcgagctttc ggccgctata atggaataca taaaacatcg gttccgccgc 3969781 atcgtgggaa acgccaaacg attcaacatc aagtccgccg aacgacttca ccgtctccat 3969841 tggaaataca aacttttgat cggtgtcaat tttgccgatt tgattctcca tcgctttcca 3969901 agtcttctca ttcgcataga tcggaagctt gtactttctg gcgacgacac caaggccctt 3969961 aatatggtca ctatgctcat gcgtcacaaa aatgccgtct acatcatcca gcttacgccc 3970021 gatctgcgcc atcagcccat ccatggcttt tccgctcaaa ccggcgtcca ctaaaaatgc 3970081 gtgatcctct gtttcgaggt aaaacgcatt tcccgtactc ccgctcgcaa gtacgctaaa 3970141 ttgcaagctc atgtttgtct cactccatta ttttcattga tctgtatcta aaatcgtact 3970201 ctccaaagca ttcacagtaa aatactcttg tactgtcttt ttctcaccgt tcactttttt 3970261 ctcgtactcg accgtaattc tccataccgg cgccagcacc tgcgtacttg tcagcggata 3970321 ttgtgctaca tagccgaatt tacagctctt cacagtgctg tattctttta attgattttg 3970381 atagtacaat agctcaaccg catccatttc agtaattaag ctttctttct ggatttgctt 3970441 gaaggtctca agcgtagtct ggtcgtatga cacaacctcg tttttaccgt ttaagtgcag 3970501 caccacttgc ccgatcatat tagagggatt gtcggtcttt tggtaaatat aatgaccttc 3970561 gtacgtttgg aagaaaataa tttctttctt cgatttatca accttccaaa gcttatattt 3970621 ttcgccatct tgaattttcg aagaaacaag tgcctgagca tcgtcctcga tatccttctt 3970681 tgatagtgcg attggatttg caaacttcat tttcaggctc gttactttat gatcatcact 3970741 aggcatgtcc atcaaaggct tttgatcctt cagcgcctca atttcctcct tggagaaaga 3970801 cttttgattt gccgtgatcc gatagccttc tgttgcttcc ttattcaagc cttcatacgt 3970861 gatatgatcg gccttcatgt catgctcgac atcattttta atgacttcat attctttgcc 3970921 ggtagcctgc catttttgaa aaaactgata gcctaagaaa atatctaaaa tgaggaaggc 3970981 aacgatgaag attgattttg tcttattcca ctccactgtt agccccctcc ttcctcaata 3971041 aatcctttgt aatcggcaca atttttccat ttactttcat cgcccaaacc ggttccagtt 3971101 caacgagagg atcatcgttg gttgatgttg ataccaattg ataagcaagg aagatctgat 3971161 caattttgtc cgtatcataa gcggtttgtt tcgaaagcag catcttcact tcgctgccgc 3971221 ccatgagctc tgtttcactt gttttaatcg gattcgttcc gagactgtaa ttcggccgct 3971281 tatagctgag aatatcatca ttcgcccatt gcaccgtaat cgccgatgtc gccccgaaag 3971341 gtttggcggt gctgttaatg accgggatct gatccataaa aatatagaag ctcaactgct 3971401 ggctgtcatt gatattgaaa aattgatagt gatccgtcca gcttccggta tcctcaaggt 3971461 atttttggct ctttttgatt aattcacctg tttgatagga tgtgctctgc accaaattgc 3971521 gctgctgaaa ttgcacctgt ctctggctta gattcacatc taaccggctg atcccatctg 3971581 tcagcacatt tctgttgttg taattcgaat cttctcttac aatgctcgga tcactaaaca 3971641 aagcctgctt aaaggtattt gttttaatcg attctgtgac aaattctttt ttgtccatcg 3971701 taagcggttt gttcggcagc aagaactctt tctttgagcc aatggagaac aaactgaacg 3971761 ccggcatatt tgattgcctg tttttcaagt cgttcataat gttccggtag tttgctgatt 3971821 caaccgtcac ttcaagaatg agctgcttgc tgtatgacac caaatagatt ttcttgttcg 3971881 cttttgtttc attgaacggg atcagaatat ggtcaaacga actgtattca aacgactgat 3971941 tagaccattt aaacagcgtt tggaaaatat caatcgggat cgtatcgctg aattgcaagt 3972001 caagcttggc ttcagaaccg cctattccat aaaaccagct tttgaatcca gccttgtcat 3972061 actgatccga aatatcttta attcctttca catcccaatg cggcaagtca gaccaaattt 3972121 cttcatagag ggcattgtca tccactttgt aatgagcgcc gtcatcatgg ataaacatgt 3972181 cccttggcct taccgtttca gacagctttt gggtggtttt ttcgatttta tgtttcacac 3972241 gaacagtaga ctctgttgag gatgagcctt cagaaaagtt tggctggaac gtccatatcc 3972301 cccatgtaaa aacaagactg atgacgacga gtaccgtaag taatatcgtt tttatatttt 3972361 cacgcttcat cccaatcatc ctcttgttcc tctttatatg gaagagtaaa tgtaatcgtc 3972421 gtgccttttc cttctatgct gtccgcccaa atatctccac cgtgcgcctg taccatttcc 3972481 ttggcaatcg ccaatcccag accggtgccg ccaagctttc tcgttctcgc tttatccacc 3972541 ctgtagaagc ggtcaaagac tttttcgaca tcttttttcg gaatgccgat cccttcatcc 3972601 ttcacgctga tatagagaag ttcttcctct tcattgacat caatcgagaa cgtgacatgt 3972661 ccgccttccg gtgaatattt taaagcgtta gaaataatat tatcgagcac ctgcgttatt 3972721 ttatcctggt caatctcgac atacagatct ctgtccggca gattgcggat aaactccaca 3972781 tgctgctctt ttgtcatttc aaaacggtca ataataagtg acataaaccg gacaatctga 3972841 atccattccc ggttaaattg ataatcttta ctgtcaaatt tcgacagctg aagcagatca 3972901 ttgacaagcc ggatcatacg ctctgtttca ttttgcgtca ccattaagaa gcgcggagca 3972961 atgtctttat tttcccacgc gccttcagct aacgcttcta aatagctgcg cattgtcgta 3973021 agcggcgtcc gcagctcatg tgatacattc gcaacgaatt ctctgcgttc ctgatccatt 3973081 ttctcttgtt cggttacatc gtaaatgaca gcgattaaac catcaatttt gccgtgttcc 3973141 ctttgaatca cagagaaatt cacgcgaagc accgttaatt catcatcgcg ctcaatttca 3973201 agcagcatag aatcctgctg ttccactaaa tcttcaaaag tataattctc ttgaagcccc 3973261 agcaaactcg taatcggcat ttctaaggct gtttcacgtg aaacgttcaa cagttccagc 3973321 gccgggctgt ttaagagaat aatcgctccg tttcggtttg tggcgataac gccgtctgtc 3973381 atataagcaa tgacagaggc tagctttctg cgttctcctt cagtcatcgc ctgggcatct 3973441 tcaagctctc tcgttaagtg gttaaacgtt gtggccagct gcccaatttc atcatgtcca 3973501 tactttttaa ccttcctcga gaaattccct ttcgcaagct ccatcgcctg ctttcgcata 3973561 tctgaaagcg ggtgggtaat ggttcttgcc agaaaaatac cgagaagagc cgtcaaaaca 3973621 agtgccaaac ctgtgccgga cgccagtatc gtgttgatcg tcttcatttg attaaagaca 3973681 tcttccatac tcgcgacaac gtagatcgcg cccacaacct cttggttttc agtcatgacg 3973741 ggcttcgcgg aaataagaac tctgattttg cttttcgggt cataatattt tcttaaatac 3973801 gactgtttgg tagaaaagat tcttttgaaa atcagatcgg tcgtttgttt cccagccact 3973861 tcctcaccgt acggctttga agaaccgacc acttcatagc ttttatctac aaagctaatt 3973921 tcccgaacct catcactttt cgtgaagtca ttcaaaatac ggctgacgtc atcctttatg 3973981 acggtactgt cgttatcgct cttatattct tgttcgatat aataagaaag gttgtcgatt 3974041 cgctgattca gcgattgttc ataagagctg atcagcgact tctctacctg attgacaaaa 3974101 tacacaccaa tgatttgcat ggcaatgata atcaaaagca cataaatcaa ggtaatctta 3974161 aattggatcg accgaaaaaa accaacctta ttcatatggg cattagtcct gttctgggtt 3974221 tctcaagtaa taacctacac cacggcgtgt gacgatccaa tttggatggc tcgggttgtc 3974281 ctcgattttt tcacgaagcc ggcggactgt tacgtcaacc gttctgacat cgccgaagta 3974341 atcatagccc caaacggttt gaagcaaatg ttcacgggtc atcacttgtc cgatatgttt 3974401 tgctaaataa tgaagcaatt cgaactcacg atgagtcaat tcgattgttt cgtctcgttt 3974461 tgatacaacg tacgcgtcag ggaagatgac gagagagccg atatgaatct cgttagagga 3974521 aggctcttcc tccgcaggcg ctgttgtcag ctggcggcgc aggttcgctt ttacacgcgc 3974581 caagagctcg cgtgtgctga atggttttgt gacatagtca tcagcaccga tttcaagccc 3974641 gataaccttg tcaatttctg aatccttagc cgtcagcata atgattggca tatcgtattt 3974701 ctttctgact tcgcggcata cttcaacgcc gtctttattt gggagcataa tatctaaaag 3974761 aattaaatca ggctgaagct cttctaccat ttcaacggct tcgtttccgt cgtgggcaca 3974821 gtgcacttca tagccttctt ttcttaagtt aaattccaat atatctgcaa tcggtttttc 3974881 atcatctact acaaggatct ttttatccat cattttgatt ttcctcctgc cgaatgactt 3974941 catttcatct atataacatt cgtttcatca cttatggccc atgtaaagaa tgggtccttg 3975001 tctattataa cggtttaagg tcaaaagata aaaaaaataa aggtttagaa aaaaaacaca 3975061 tgtttcacct ttatcgccag ttgtttatct attgtcatgc tggtcaactt tttttaaaaa 3975121 agataacttt attgaaacct cccctcaccg gagtgcgtct ttatcaatga cgtcttcttc 3975181 tttgaaccgg ccgcagggcc ggttctccct ttttcttcta ttataacact cctcatgttt 3975241 gcctttttcc taaaagaaaa aacgcaccta cgattgcaga tgcgtttggt aagtggctcg 3975301 ggacggaatc gaaccgccga cacacggatt ttcagtccgt tgctctacca actgagctac 3975361 cgagccaaat gttttatttt tctctactaa gtaaagtaaa atggcggtcc ggacgggact 3975421 cgaacccgcg acctcctgcg tgacaggcag gcattctaac caactgaact accggacctt 3975481 acagtaattg cccggagagc tgtcgtgtca gctctcacag acaaataagg aatttagcaa 3975541 taacgctaaa gtaaatcaat gacccgtacg ggattcgaac ccgtgttacc gccgtgaaag 3975601 ggcggtgtct taaccgcttg accaacgggc cttcacgaaa tggtgagcca tgaaggactc 3975661 gaaccttcga ccctctgatt aaaagtcaga tgctctacca actgagctaa tggctcttaa 3975721 agatgtcgga atttctatag agcaaacgac ttaaatctag ttctcatctt gtactctatt 3975781 gaagcagttt ccgtaacaac gagatttata atatcacgaa caaatagaag tggcaataac 3975841 ttttttggtt ttttttcata tttttttctc agaccaactt atatgcggct ttcaaacaaa 3975901 aacaagcccc ttaaataggg gcttgcagac atattctatt tagttcgcac ggtacacact 3975961 gcgaaggaca tttgtttgtg agcggtctgg accgacagag aaaatagaaa gcggaatgcc 3976021 tgtcagctga gacacacgct caagataatg gcgcgcattt tccggaagct cgctcaagct 3976081 cttcgcacct gtaatatcct cagtccagcc cggcatttct tcatataccg gctcacattc 3976141 agcaagtgcc ttaagacttg ctgggaattc ttcaatgatt tcgcctttgt agcggtacgc 3976201 cacacagatt ttcaacgttt caattcctgc taggacgtca attgagttca gagaaagatc 3976261 tgtaattccg ctcacacggc gggcgtggcg gacaacaacg ctgtcaaacc agccgacacg 3976321 gcgcgggcgg cctgttgttg ttccatattc gcgtccgact tcacggattt gatcgccgat 3976381 ttcatctttc agctcagtcg gaaaaggacc gtcgccgaca cgagtcgtat atgcttttga 3976441 tacaccgaca acgtgcttga ttttggtcgg gccgacacca gaaccgatcg tgacaccgcc 3976501 ggcaaccggg ttagatgacg taacaaacgg gtatgttcct tggtcgatat cgagcataac 3976561 cccttgtgcg ccttcaaata atacacggcg cccttcatca agagcatcgt ttaagacaac 3976621 agatgtatcg caaacatact ttttaatctg ctgtccgtac tcataatatt cgtctaagat 3976681 atcctcaagt ttaaaccctt ctgtctcgta cattttctcg agaagacggt ttttttcttc 3976741 aagattgcgc tcaagctttt ccgcaaacgc gtcacggtct aacagatccg cgatgcgaat 3976801 tccgatgcgg gctgctttat ccatgtaagc agggccgatt ccttttttcg ttgtgccgat 3976861 cttgttagcc cctttacgct cttcttccac ttcatccaat ttcaaatgat acggcagaat 3976921 gacgtgagct ctgttgctga ttctcaggtt atctgtactc acgttgcgct catgaagata 3976981 cgcaagctct gtgactaatg ctttcggatc tacaaccatt ccgtttccga ttacacacgt 3977041 tttatcctta tagaaaattc cagacgggat taagtgaagc ttatatgtga ttccgtcaaa 3977101 cttgattgta tgccctgcgt tatttccgcc ttgataacgg gcgatcactt ctgcattttc 3977161 tgataggaaa tctgtaattt taccttttcc ttcatcgccc cattgcgtac ctactacaac 3977221 tactgaagac atgtccgtgc acctccgtta acctttcaaa acgattctat tcaaacaaat 3977281 caagtttatc agtgaagaaa cagaaagtca attgtaaatc cgaacattaa tttattgtaa 3977341 atctatattc gttcgcttcc attcgtttta taagcgtttt ctcactgctt tgtcataaaa 3977401 agcttgcgaa actttcatcc tttagcataa gaaagaatca cttgcctgat atcccttttg 3977461 aattcataaa aacgatccgc cagccgtccg ggtcctctat cgtcacgccc ccattgctcc 3977521 agtacgggtt ctctgattcg acctcttgat agcccatgtg ctttagcttt gaagtgatcg 3977581 ctgccagttc aactgcattc ggcacataaa aaacaagaag gctgtcggga tggggaacgg 3977641 gggcagtgct tcccccttca tactgggtga attccaaatg ataatcggca tgaggaaggc 3977701 cgaacatgac accgtcatac ccgttatgct gtgaaaattc tcctattcgt ttcaaacaca 3977761 gtccctcttc gtaaaaacga ataatctcat caagctggcc cgtaggacgc gcaattcgga 3977821 tttgtgctgc ttgaaaagac gaaaaacgtt ttcccatatt gttaccatct cctttttgca 3977881 ccattttatt aaaacgcttt caatttttca tccgctgagc gaacgtcatt tcttccatct 3977941 ttcgaatgaa aaaaacccca agagcagctc ttggggctta tgcgccgggc ggaacgcctg 3978001 cgtcatcaaa acgccgttcc aggttgacga atttgttgta ttcttttacg aacgcaagag 3978061 acacggttcc taccgggccg ttacgctgtt tggcgataat aatttcgata atatttttat 3978121 tctcggtttc tttgtcatag tagtcatcac gataaaggaa cgcgacaata tccgcgtcct 3978181 gctcgatact tcctgattcc cggatatcag acatcatcgg acgtttatcc tgacgctgct 3978241 caacacccct ggaaagctga gaaagcgcga taacagggac ttgcagctcc ctcgcaatcg 3978301 acttcagttc acgggaaatt tcagatactt cctgctgacg gttgtccttt gaacgaccgc 3978361 ttccctgaat caattgcagg taatcgatca aaatcatgcc cagcccgctt tcctgcttca 3978421 agcggcggca cttggcacgg atttcactca ctcgaatacc cggtgtatca tcgatgtaaa 3978481 tcccgctgtt cgataggctt cccattgcca tcgtcagctt gccccaatcc tcttcggtca 3978541 ggttacctgt acggagattc tgggcattga tatttccctc ggcacagagc atacgcataa 3978601 cgagctgctc ggcacccatc tcaagactga aaatcgctac gctctcatcg gtcttcgtcg 3978661 ccacgttttg tgcgatgttc agggcaaagg ctgttttccc tactgaagga cgggcagcca 3978721 caatgatcaa gtcgttgcgc tggaaacccg cagtcatccg gtcaagctcc gtaaaccctg 3978781 ttggaattcc cgtgatatca ccttttcgat tgtgaagctg ttcgatatta tcataggtct 3978841 ggacaaggac gtccttaata ttttggaagg cactcgtgtt tttgcgctgt gccacttcca 3978901 taatcgtttt ttccgcttca ctgagtaaat cctcgacctc atcctcacgg gtatacccgt 3978961 cttgagcaat cgttgtcgca gttctgatta atcggcgaag aatcgatttt tcctcaacga 3979021 ttttcgcgta atattctatg ttagccgctg tcggcaccga gtttgcgata tctgtcaaat 3979081 atgaaatacc gcctacttct tccagcaggt ctgtgttcgc aagctctgat gtaactgtca 3979141 ccagatcaac cggttcacct cggtcaccga gcaccagcat cgcattatag attttttggt 3979201 gggacattct atagaaatca tctggaatca atacttctga agccagtgtt aaagcagacg 3979261 gctgtaaaaa aatagcgcct aacacggctt gttcggcttc tatattttgc ggaggaagcc 3979321 ggtcattcag aaggtctgtc atgctaagca ccgtcctctc attaaaaaat ctccaacctc 3979381 cattctacca tttctacaga aaaaaaatag aaaaattgtc tgtttcctgt ttttttcagt 3979441 tagcagattg gatcgtttcg gacagtaaca aggcgggaaa aatgcaataa aacataaggg 3979501 aggaatgaaa gatgataaag aaatatgcga ttacacctaa tgttgatgcg gacggctggt 3979561 ttattgaggt ggagaatgta gcgccgacag ctttgtatac gtctaaagac gccgctattg 3979621 aaaaggccaa acaggtggct aaggaaaaca gtccgtctaa gcttgtaatt tatgaccagt 3979681 ttaaaaatgt ggaagaagaa cactcatttt aatgaatgaa agccttcgct gcagcgaggg 3979741 ttttttagcg gttatcggtt tatttcatcc attggatgcc tatgtgcatc atcaaatctg 3979801 ccgctttttg atacagatcc cactccccga tcgaagcaaa tttccccatc agctcctgaa 3979861 gctttaacct cattgctata tattcttcga aagtgacagc tttttcagtg tctatttggt 3979921 gttccttcag catttgtttt aataaggata acggtgcgtg cataagaacc ctccttacct 3979981 cttttataac ggtcattttc cgattgctct attcctttgt gacatcttct tacatttcac 3980041 atctgattct tgtacaatgg acagaagaga ggagggatct tttgtgagac ctttgcaaat 3980101 ttctgccgaa actgcacaaa agcttgcaga gtccttgaat ctgccgcttg aacagatcat 3980161 gcatatgcct cagcatattc tgcttgccaa aatggctgaa ctgcaaaaag aggacaaatc 3980221 atagccttca ttcacatact tgcttacctg tttcgggata atatcatgta tatgttagaa 3980281 aagaggagta actgctttgc cacatccaca taataaaaaa atccaatcat tttggctgat 3980341 caccggcatt atctttatcg cctttaactt acggcccgcg atcacttcag tcggtccggt 3980401 catcagctct atccgggcag agctgcacat gtccaatggg gcagccggtt ttttgaccgc 3980461 actgccgctg ctttcgtttg cagttctttc tccgcttgca cctaagcttg gacagcgcct 3980521 cggtaatgag cgaactttat ggctaggtct cgtgatactg ctgatcggtg ttctgactcg 3980581 ttctaccggc tatactgccg ctttgttttt cggaacagca cttatcggcg tcgggattgc 3980641 gattggtaac gtacttttgc caagcttaat caaacataaa taccctgaaa agccagggat 3980701 catgatcagc ctgtatacga catcaatgaa tatattcgca gctttagcat cgggtgtcag 3980761 cgttccttta gcgacccaga tgaatggcgg atggaaacaa gcctttctct tatggggcgg 3980821 gctggcttta cttgcattgc taatctggat acctcagctg cgccatcgag atacggcaaa 3980881 ccagacaatg aagctgcaat ccagttccat ttgggcttcc aaaatggcat ggtatgtcac 3980941 catctttatg ggcctgcaat cgtttttatt ttacagcagc atcgcttggt ttcctgaaat 3981001 tctccgttca cacgggattg atacggcaac agccggatgg atggtatcac tcatgcaatt 3981061 tgcgagtctg ccttccactt ttctgacgcc agttttagct gaccgtgtga aacagcagcg 3981121 cggtatcgtt gcggcgctgg cctcagttta tctgatcggc ctttgcggat tattagcggg 3981181 cggaagccat acattgcttg ccatctggat gatcattatc ggtatcggac aaggctccag 3981241 cattagtctg gcccttactt tgattggtct ccgcagtgaa aatgcccaac aggccgctgc 3981301 gctgtcaggc atgtctcagt cattcggcta cctgctggca gcagtcgggc caatctttgt 3981361 cggctatctc tttgaccaga cgcattcttg gacgatgccg attgtgcttc tcattgctgc 3981421 cctgatcgta atgggagcag ccggacaggg agccggacga gatcgataca ttttccagtc 3981481 agaaaaacaa agaaattcag cataaagcgg ggaagatatc tccgcttttt tctttgaata 3981541 tttatggttt attcataagt ttttcatatt tgttttttac aatgagacac cataaagagg 3981601 tgaaaaacga tgaaaaccaa acgattcgac gcagccctta ttcttatttt gctagcagca 3981661 gcttttttga atacgtatca catttggcag gatgatacag caaaccagta ctatttggcg 3981721 gctgtaaaaa gcatgacgca aagcttccat aacttttttt atgcgtcatt tgacccttct 3981781 ggatttgtga cagtagataa gcctcctgtc gtgttatgga ttcaaacgat tttcgcactg 3981841 attttcggtg ttcacacgtg gagtgtcatc attccccagg ctcttgccgg agttggatct 3981901 gtcttccttc tctacagaat ggttaagccg acttttggag ttggagcggc ccgcattgcc 3981961 gcacttgtca tggcactgac ccctatcgca gtagctgtca gccggacaaa caatatcgac 3982021 agcatgcttg tttttacctt attgctcggt tcaacttgtc tgcttagggc agtaaaacaa 3982081 ggcaagctgg tttggctgct gacggcattt gccctgattg ggctcgcctt taatatgaag 3982141 atgatgcaag cgtttatggt attgcctgca tttgtgttat tctacctgat tgcatctcgg 3982201 gtttctctga agaaaaaaat cgggtccctg cttctgtctc ttgtccttct gacaggcctt 3982261 tcactctcat gggcgattgc agtggattca gcctcttcct caagccggcc ttatgtagga 3982321 agcagccaga ctaactcagt gctagaactg gcctttggct acaacggcac agagcgtctg 3982381 tttgggcaaa ctacgggcct tgcaaagggt gatatgaatg ctgctggcgg agggaacatg 3982441 cagaatcaag acaacatgca agcgccaaat ggcaacggtt catctttttc tcagaacggt 3982501 aatcaatcat tcggaaacca ttcacaggcg cctcagccgc ctaacggaca aaccggcgct 3982561 ctcaatggag gcggaggcac acctcccaca ggtggcaacg gacctggaaa tggagggcct 3982621 ggcggcggag gcggaaaaag cgtgaatatg ttcggcaccg gtgatcctgg accgcttcgt 3982681 ctcttccaat cagcactttc cggccaaatc agctggatgc ttccattctc attgatcgga 3982741 ttactgggcg caatcatcag ctggtaccgt gatcgccgcg gacatgctgc taaaatgaaa 3982801 gaaacgctat tctgggcggc ttggcttgtt cccgtggctg gtttcttcag catcgcagga 3982861 ttcttccacc agtattattt gattatgctg gcaccgccga ttgccgccct ttctggtatc 3982921 ggatggtata cgatgcaccg cttatacaaa aataataaag actggtccag ctatcttctg 3982981 ccggcagccg tcttgatcac agccgtgttt caggtgtata ttctgagcgc ttatacaagc 3983041 caaatcggca gtgtatggat gtatgtcctg gggctcttag gactgggcat cacccttgca 3983101 cttctgatgc ttaaacgcag ccatccgttc agtaagctgc tgaccatcat cagcttgtgc 3983161 gttctgcttc tcacaccagt ttactggtca gcaacgccgc ttctatacgg tggcaacagc 3983221 gtccttcctg aatccggccc gcagctcaaa ggctcagcaa acggcgggaa catgttctct 3983281 tcagaggtcg acagcgggct cctgtcctat ctgagaaaac acaataccgg cgaagagtat 3983341 ttatttgcta ctttgacaac cgtaacagct gcgccataca tcatttacga aaatgaatct 3983401 gttatggcaa tgggcgggtt taacggcacg gatcccattc tgactgtgtc ggaactgaaa 3983461 aaactgatca aagaaggcaa agtgaaatac ttccttctgt cagaaaacaa ctcaggcaac 3983521 agcgaacttg tttcctggat taagaaaaac ggaaaagaaa taacatctga cgagtacagc 3983581 ggttcctcca gcagcacaaa cagcgtgcag ggaatgcgaa gaggacctgg cggagaaagc 3983641 cagcaaactc tttatctcgt ggaataaaaa aagaggcttg gatgaatcca agcctctttt 3983701 ctattaagct tcttctttta catgtacctt taacacagcc tgcacttcag gatgcagctt 3983761 cacaggcacg tttgtatatc ctaatgcacg aatgccgtcc ggcagttcaa gcttccgctt 3983821 atctacttta atgttatggt ctttttggag ctgttcagtg atttgcttgc ttgtcactga 3983881 accaaataaa cggccgccct cacctgattt tgcgctaagc tcaacagtca gtttttctaa 3983941 tgtctctttc aagctcttag cctgctcaag ctcagcaatg gcttcttttt tctctttctg 3984001 cttttgtccg tttaacgcgc tgatgtttga cgcgttcgct tcaaccgcga ggcctttttt 3984061 aattagaaag ttatgcgcat aaccgtctgc tacgtttttg acttcgcctt tttttccttt 3984121 tccttttaca tcttgtaaga aaataacctt catctctgta cgcctccctc aaaatactca 3984181 tctatggcgt gcttcagccg ttccagcgct tcagaaactg aaatgccgga caactgagtc 3984241 gccgcatttg ttaaatgccc tccgccttcc agggcctcca tgatgatctg aacatttacc 3984301 tcgccaagcg accgagcact gatacaaacc gtttgttcat cccgtctcgc caccgcaaat 3984361 gaagcctcaa cctcactcat cgatagcagc gaatcggcag cctgcgcaat cagcacttga 3984421 tcgaagtatt cctcttcatt ttcaggaaga gaagcaatcg caatgttatc tttatagagg 3984481 accgtatgct ggatcagctt cgcccgttta atataggaat caacggtttc tttcagaaac 3984541 ttctgcacca gcaccgtgtc ggcgcctttt gcccttaaat aagaagccgc atcgaaagtc 3984601 cgcgagcccg tgcggagaga aaagctcttt gtatccacta ttataccagc taatagggct 3984661 gttgcttcaa tcatattgat ttttaagcgc ttcggctgat attcaagcag ctctgtcacc 3984721 aattccgctg tggaagaagc gtatggttcc atataaacga gcagcggatc tctgataaac 3984781 tcctcacctc ttcggtgatg gtcgatgacc acgatatgtt caattttatt gaccagccgt 3984841 tcctccatga cgagtgacgg cttatgtgta tcaacgatca caagcagtgt gtcatcattg 3984901 gaaatctcca ttgcttcttc aggcgtaata aatcttgacc acagttcttc atattttttg 3984961 atttccccaa tcaaacgctg cacacttgat ccgatttggt ttgggtcaat cacgataaaa 3985021 ccatctttgt tatttgcctg agccaccttt aaaatcccga tcgctgcgcc gatagaatcc 3985081 atgtcgggga atttatgccc catgataatc acattgctgc tttcggtgac gatttccttt 3985141 aaggcgtgag aaatcacgcg ggcccgcacc cttgttcgtt tctccattgg gtttgtttta 3985201 ccgccgtaaa acttcacctt gccgtttggc agcttaatgg ctacctggtc tccgccgcgt 3985261 cccagtgcta agtccaagct ggattgcgcc aaatcgccaa gttctttcag ggaagagact 3985321 gaagccccga caccgacgct taacgtcagc gctacaccgt caaacgaggt tttttcccgc 3985381 acttcatcaa gaatcgaaaa cttcgaattt tcgagttcag ttaagatatg ttcattaagt 3985441 acagcaataa agcgttctga agacgtcctt ttcaagaaga tcccgtactc ctgcgcccaa 3985501 gcgttcagca aagatgtcac ctggctgttc atcgtgcttc tcgtctggtc atccaatcct 3985561 tgtgtcacat catcatagtt atcaaggaaa atatatgcca ggacggttct ttcgttttca 3985621 tatagctttt caatctggat ttgttctgtt acatcaaaga aatataagag acgctcatcc 3985681 cgtttgatga caaccctaaa cttgcggtca ttcaatgtaa ccgtttccga ttccacctct 3985741 tgtttgataa gcggcactac cgattcacaa gtatcgtaaa gtgatctccc cactaaagtg 3985801 ctttcattaa aacaagagga aagaaacgga tttgcccatt ctatataata ttggtcatta 3985861 aaaagcatga ttccaatcgg catttccatc aatgcctctt caccgacttt tttcaacctg 3985921 taggacaacg tagaaatata agcatcaatc tcttgtcgaa taagagaatc agcacgctta 3985981 ataaaaaaca aaataactgc cagcagcagc acttcgacgg ttcctaatat ccagttaaaa 3986041 taaaagctga tgaggattgt aataattgac agagcaatca atgcatagat gggataccga 3986101 aacagcggtt tttcataaaa gcttggcatt tctatcactc cccaccatgt gagtaaaact 3986161 catgttcact tcaccttatt ccttatatga aagcccatat ctaaaacgcc taaaatgcga 3986221 atggccgcca tgaagaccgg atgcacaaac ccaagtatga cagcaatcac agccgcagcc 3986281 tttggatatt gtttcttatg gcaatagaaa aagataaatg ataaaccttg gatgaaaatc 3986341 agaaacccga gtataaactc cccatttaaa gcgatagagt acagcatttg gcctttttct 3986401 aaaggcaaaa atgaaagcat gacaataatc aaatacagta ctacaacact ttgcggaaac 3986461 ttcaactctc taaaaggctt tagattagga atatcggggg agaatcgcct taagagcggc 3986521 ttagcgataa ggtaactgag gaaagaaaaa ataactccta ccatcacaat agctgttgga 3986581 aaaagatatt gaacgatacc caattgttct tccatcagtt ttaattgctt ctcaaactgc 3986641 ccagcattgc ccgactgctt cgctacagtt tctacaatat caagagattg ccggtattgt 3986701 gtcattgcct catcaatgat attgataccc aaaaactgaa tgcttatcac aaaatagaag 3986761 acaatactaa gcatataaat aagagcgccc gaaataatgg cgtgcccggg ctctttcctt 3986821 ttgaaaaaat gtcccatggc aatgccggcg caagctgaca taaaagctac aataagcccg 3986881 ttaaaggacc cgacaataaa aacaaccgga agactgacag cgcccatcca tatccctagc 3986941 ttcaatccat gtctgatcgt atacaagatc attggcagcg gcagtgcaaa taacagaatt 3987001 gttccaatca caggaacata aacgaccaga agcgtaatga tcgcaaacag actgattaaa 3987061 atagcacctt ccattaaagc tctcgtttgt ttcacttagt cacctcgtat catcctgaac 3987121 atacgaatag aaaagagcag cataaacgac tgctcttttg ttcatcgctg caacatgctt 3987181 tgcaccgaat gtttttatat catctctaaa ttttactttt atattttaac ataagtccaa 3987241 atcgcaagta aaatgacgct aatgtttcat gtgaaacatg aaaaaggaaa agacattctt 3987301 tgaaaagaat gcccatcaca attaatgttt atcatccata aagccagaag attccttgtt 3987361 tttctttttc gtttttctga catacataaa aattaagatc accagtaaaa gggttgttgc 3987421 ttgcagaacg ccgctgctaa acaagaaaaa gttctttatc atgtcccaca ttgtgtttca 3987481 cctctttgtg catgttctca acccgtatcc tatataaggt gaatttccct ttttaaaaac 3987541 ttcaaaacat catgaacaac attgagcgtt gggcatatgc tgatatggaa tctgatcgat 3987601 aaaggagaat tttcacatgg atgaacgcag aacattggct tggcatgaaa cattagaaat 3987661 gcacgagctg gttgcttttc aatcaaacgg actcattaaa ctgaagaaaa tgataagaga 3987721 agtaaaagac cctcagctca gacagcttta taacgtgtct attcagggtg ttgagcaaaa 3987781 tttgagagag cttcttccgt tctttccaca ggctccgcac agagaggatg aggaagaaga 3987841 acgcgcagat aacccatttt acagcggtga cctgctcggt tttgccaaaa catctgtccg 3987901 cagctatgcc atcgcaatta cagaaacagc aacacctcaa ttaagaaacg tactggtcaa 3987961 acagctgaat gctgccatcc agctgcacgc ccaagtttat cgatacatgt atcagcatgg 3988021 atattatccg tcttacaacc tttctgaact gttgaaaaac gatgtcagaa acgccaacag 3988081 agccatttca atgaaataaa acaagcagca aaggagttcc ctttgctgct atttctgctg 3988141 atccttcact aagccgttcg aacgataaga ttccagcacg tctctgttgg attctcccca 3988201 ttctttcatt tgcaaaacaa tcggttcaag cgtgcgccca aattccgtca gagagtactc 3988261 taccttgggc ggcacctggt gataaacctc acggtgcacg atgccgtccg cttccagctc 3988321 cctcagctgg agagtaagca ttctttgagt aatactcggg cagattcgcc gaaactcatt 3988381 aaatcgtttc ttgccatcta tcatgtgata aaaaagaatt cctttccact ttccgccaat 3988441 gacatctaga gtgaattcaa ctggacagcc ttctttgttc gggtatatat tctttttttc 3988501 actcattctt gaccctccaa tagtaccttt tttgatacta cattacattt tgcaactaat 3988561 ctacccagta ttttacacac cttttctcct tagctcaaag aaaatgcttc ttattcacat 3988621 caatttttaa gggtttgcat gattacacct gcagcaagac gtgttaaact atataaagat 3988681 tacactactt aaaaaaggat aggagctatc atggaaaaga tacttatttt cggacaccaa 3988741 aacccagata cagatacgat ttgttctgcg attgcttatg ctgatttgaa aaacaaactc 3988801 ggcttcaatg ctgagcctgt ccgcctcgga caagtcaacg gcgaaacaca atacgcgctt 3988861 gactatttca aacaagaaag cccgcgtctt gttgaaacag ctgcaaacga agtaaacggc 3988921 gttatcctgg ttgaccataa cgaacgccag caaagcatca aagacattga agaggttcag 3988981 gttttagagg ttatcgacca tcaccgcatc gctaactttg aaacagctga gccgctttac 3989041 tatcgtgctg agcctgtagg ctgtacggct accatcttaa acaaaatgta caaagagaat 3989101 aacgtgaaaa tcgagaaaga aattgccggc cttatgctgt ctgcgatcat ttctgattcc 3989161 ctgttattta aatctccaac ttgcacggac caagacgtag cagcagcaaa agagcttgcg 3989221 gagatcgctg gagtagatgc tgaagaatac ggcttgaaca tgttgaaagc aggcgctgat 3989281 ctaagcaaaa aaacagtgga agagctcatt tctcttgatg cgaaagaatt tacactcggc 3989341 agcaagaaag tcgaaatcgc acaagtaaac acagtggaca ttgaagatgt aaaaaaacgc 3989401 caagctgaat tagaagctgt gatctcaaaa gttgtggctg agaagaatct tgatctgttc 3989461 cttctcgtta tcacagatat cttagaaaat gattcacttg ctcttgcaat cggtaacgaa 3989521 gcagcgaaag tggaaaaagc gttcaacgtt acattagaaa acaacacagc cctcttaaaa 3989581 ggcgttgttt cccgtaaaaa acaagtcgtt cctgtcttaa cagacgcaat ggctgaataa 3989641 gcaaaaagca tcccgcgtcg ggatgctttt tcttattcac ccagcttctc aatttgtccc 3989701 atcacatcag taatttgctt tgcgttttgg accaggtctg actgctccaa ttctttaagc 3989761 gataccttgc cttcctcggc ttgtttcaac acatcttcag cgcttttctg caaggtttcg 3989821 ttatgctcct gaatggttcg atgaatctcc gctgcggcat caggcggcgt taattcatta 3989881 aaatcagcgg cagccttctg aatcgactca agctgcgctt caagtttttc tttcgcctcg 3989941 gtgtcattta cagctttctc agccaattca ggcgcttcct ctgcaaatgt cttcaccttc 3990001 tccacataac cagctgcttc actcgtatag ttcaatccgt cgttcacctg atcaagcatg 3990061 ccgcatccgc ctgcactcaa aagtcccact ccggcaagta ctgtcaaaat gatcttcatc 3990121 ttcagccccc tcatcgtttc tttttcattt tttcttttaa gatcggaatc aatttctctt 3990181 tcgctaacgg cagccctttc ctcaccaatt cacgcttcag ccactttttc agcttagaca 3990241 ttctgatgct cctctccctt tttgataaaa atgaaaaaac tccaccaatt tggtgaagtt 3990301 cctgaaacaa aaagaccttc accaaatcag atttggcaaa ggtctcgcta acaatgagat 3990361 tgccagcaaa gccgaggaca ccttgtcccg taatgacgac tttactgtga aagctactcc 3990421 cctttggagt gttcattttt attactttca ttctaaagca ccgatctgtt ccagtcaaat 3990481 tcctgccgtt tatataaaag cgcgctgtgg tatttaaaat ttgaatggtt tttctatcag 3990541 gagatcatgc tatgacagag gaggttttca tcatgagtca agagcgcgtg aaacggcctg 3990601 ggcataccag atggtacata tcttcgttac ttagcggcat tattattctt aattattttg 3990661 accgagtggc catctcggta gcggcccctg cgatacaaga ttcgtttcac cttactgcaa 3990721 ctgaactcgg catcgtgttt tccatttaca cctattccta tacactgatg cagctgcctg 3990781 tcggaagttt gctggaccgt tttggggtcg catgggtcac gagggttgga atgacaatat 3990841 ggagcttttt aacgatcctt cttgcttttt tgcaaggaaa attgctgttg tatctgttcc 3990901 ggtttctcat tgggctgacg agcgcctctg cgttccctgc tgcctctaaa gcaaccgctc 3990961 tctggtttcc tccaagtgag cggggattgg caaactcact gttcgattcg gccgccaagt 3991021 tttcaaatgt aatcggcgcg ccattggtcg cctttcttgt cacaacattt gactggcgtg 3991081 tcgctttttt gacgattgga tgcatcaatg tgctgtttac gatctttttc tggcagtatt 3991141 atgaacagcc tgaacggcac aaacgcattt ctaaaagtga actaaactat attcaaaaac 3991201 acaatgccat tacaacagag caaatccctt acaaaacggg cccgctttta aaaaagcttt 3991261 tcaccaatcg aaaagtatgg ggcttaatga tcggatttac agggtacggg tatacattca 3991321 acctgctgct cacctggctt ccgactttct ttaaacatac atacggtatg gatctcatgt 3991381 cgtccggttt atttacggca gtgccgtggc tgatctcaac catttccgga attgccgtcg 3991441 gcggctggct cgtcgattat tttattaaga aaggctatcc taataccaag gtgtaccgaa 3991501 ccgtaatcat agtcggaatg agctttggct ttttcttttt aggatccatt ctgacgaaca 3991561 atattaccgt agccattatt tgcatttcca tcggactcgc cggaatttcc gcaaccgctc 3991621 cggtcggctg gtccatctcc gcagaactcg cgccgatcgg ttccgtatcc atgctgagct 3991681 ccatggtgaa tctcgcaaac aacctgttcg gaggcattat tgctgcgtca ctgacagggt 3991741 atttgtttga tgtgacaggc tcctttaccc tcagctttct ggtagctggt tttgtgctgt 3991801 tgctgggatt ggttttttat gtgtttgtat taggggatgt aaaacgaatt aaactataga 3991861 acatgaaaaa gagagctgcc agttggcagc tctcccttta catcaaagaa tcggcccgtc 3991921 cccatttacc ttctcctcgt cctgttcctc tatatcaagc cccgaagcta gcatttcctg 3991981 ctctatctgt tcgagcacct gctcgttttt tccttgaaga ccaccttcat aatgaaaagc 3992041 atcctgtgtg ccgttttcct ctattgtcgc taaaatatcg tggatatcat tatggtctcc 3992101 tgaaatggag ccgaatccct ggttttgttt tttataattc acaaaaccgc tggggaggtt 3992161 gtttccgagg tttacacatg atgcgctccg agtagtaatt catcagtgta tcaaaatctt 3992221 cattttggat tgccacatca catgcagaga tgatgtcttt caattgctgt tccaaatgaa 3992281 ttcccctaat catcatgatt ggatatatta tacaatgttt gacacgtagg gatccttttc 3992341 atttttgttt ttacggtttc gctggtccat ttccgcagag ctggcgccga tcggttccgt 3992401 atccatgctg agctccatgg taaatctggc aaacaacctg ttcgaaggca ttattgcggc 3992461 ttcattgacg gggtattttg tttgatgtga caaggctcct ttacgctcag ctttctggta 3992521 gccagttttg ttctgctgct tggattggtt ttttacgtgt ttgtcttagg ggatgtaaaa 3992581 cgaattaagc gggaataaag agtgcttgta gagaaaacgt tgttctttct acaagctttt 3992641 tagttttgtg ctgtttttca agatattcag ctgtcataaa aagaaaatga gctcccacat 3992701 accggctagg tatgtggcgt tcttcttcat gttctggcat gcagctgtga ggaggatttg 3992761 tttgctcacc ccctgaacct gcgatagcta agcccgtgca gttgttttga acctacaaag 3992821 cttcgttcta ttttttcttt tcttttttta gagatttcct gaaatagaaa agcaatcttt 3992881 tctaaccttt tctttatggt tttgccatac ataccgagta acgactttct ggcgtttcgt 3992941 tgattttgtg taatattctc aaacatattt caggatttga tttatatgac cgatagtctt 3993001 tgcgatcaat tgttgagtac gtaagtgtat gctgattcaa caaatgtatc tgtattgttc 3993061 actttataat gaaatttcca ttttggaagc aaacccctga ctgggtgata acgtctatgt 3993121 gcgatggcac caaaaacttg gaggtcaaat agtcctttag agatgagagt tgttaagtag 3993181 ccggaatcta gagcgacggc ttctacttga aaatcaaatc atgcaattta gtgatccaat 3993241 cggtcaaggt agggcttgga acagaatcat ggacttttct ggagttgcaa actattaatc 3993301 gtcctcatta aatttataat aaaaatattc tcaattgagc aaatcgccca ccctttttcc 3993361 tttataacat aaaatccaat actatcaata aaattcttta caggttatta cagttaagat 3993421 ataatatagt taatctttta cgtaaaagga ggtttttatt acttgtgttg aagttttaaa 3993481 taggagtaac tccatctccc cattacggtc ttcatttaat ttcatcctga gttttattta 3993541 gttagatata aaaacgaaaa tttcacatta tttttaacta accgatagta taaaatatat 3993601 attgaaagga ttgtaaaatt atgaataaat tcctgaagag caatttccgt ttccttcttg 3993661 cggctgcttt aggcatatca ttacttgcta gtagtaattt tataaaagcc agcaatgata 3993721 actataaatt ccatttactt gtaccttatg gctatggtaa tgcctattca aatgatgcat 3993781 ttagacagac cactcataca gataatcctt ggaaagtaaa tttacagaaa tcggcagaag 3993841 gtaaaggtac aatcatgaca ttttggttga ttaacacagg gaatagtaaa attccaaaag 3993901 cttctaaaat acataacgta aaacaaggaa gcggagctca ttattatcat gcaaatagcc 3993961 agggaagcca tacatatgta gccttagcag ttgaaaacaa caattacagt gcaagttctt 3994021 atggtataga tggtgtatgg gatgaagaaa cttggtaaac aagaaccttc taaaaacgtt 3994081 ggcacctttt agccacgcga aaaaatttag aatgataatc tttttataag attatcattt 3994141 ttatttattc tattaagaat tgagtgagaa catggaaagt catatttatc gcattatcaa 3994201 aaataaatta actataataa tatttactat aatcatatta attccttgtg ttgatatatc 3994261 actattgtta atgactaaca cagaatacca tcctgcatat gcgtttttcc tttctggcac 3994321 ttccgtaggg catgcttcac aaatgatcct attatggttt cttccgcttt attttttgtt 3994381 actatgtgct gacgattcta tacaagatta taaaacagga tatcattaca ttcttataag 3994441 caaagttggc agaaaaaaat attgtttgga aaaaatattt acctctttta tcatttcatt 3994501 tttgacaatg tttttgtcac taatattaaa ctttttattg gttcaggttt tcttttttaa 3994561 aggtacattt aaaaatgact tagaccaaat taaattccct gataacagcc tttatacttt 3994621 tagtatggcc catccttata tagcaattgt gttattttct attatttgtt gtattatgtc 3994681 tggatttgtt ggagcacttg gttcaagcct cagtttactt tttcgtgata agaagtatgc 3994741 ctacccagca agttttttta tttggttcgt acttatacta aaaaacaaat cattaatgtt 3994801 tttattccaa ccgtttacag aatacggtta taatgtactt ctccctatcc tatgtttgtc 3994861 tatctttatt tttctaataa taatttctag tattgtttta tatgaggcaa aatacaatga 3994921 aaattaaaag actactatta attttatgtt tactactatt tttagttact ttatggttca 3994981 accagaacca cacttatctt ggaaagaatt ctatcgcgtc attactatat atgaataata 3995041 gtacattcgg atatagttca atatttgcat ataccttgtt ttatattgtc ccgtttctta 3995101 tgttacttag taactttttt cattcagaaa acccctacaa agtaatgagg atggttaagc 3995161 gtaaaaatta ctacaagtct aaaattatgg agattgggtt tgtttcttta cttttttctt 3995221 caatacatac tgttattaat attacgtgta cacatatttt ctttagtaaa aacttgttgg 3995281 tcgaagcaaa ctttttatca atttgtttat taaacatgat tagtttagtg tttttctact 3995341 tatcagtagg tattatgttt agacttacat acgatctgtt taattcagta gcattagcaa 3995401 tttttattgt gtatataatt ttagatagct tgtatttcgg cgttaaatta ttacttccta 3995461 atggatattg ggaacccttt agagacttgg ctatattcac aaatatgctc aatagatatt 3995521 ggtcaacttc aaatcttata atagtttata ttagacagat aataatagtt tttatttttt 3995581 atttagttgg atcttcaatt tttttgaata aggattataa aaaatgagga ttaaaggctt 3995641 tttcataact ttagttgcga taatatttca ggcgtcatta tcgagttata ataataataa 3995701 aaatgtcttt ccttttttag atggcatacc aataagcacc tcgggtcatt atgagtatca 3995761 aaatatttta ttgtggtttg tacctattgt ttccctaagt ttttgtttct ctgggagtat 3995821 tagagataca tacatttcgt atgagcaatt aaagttagta agagaacata gtagagttaa 3995881 atgggtaaca tctcaattct taataattac agttgtactt ttaatcttta ctttatctca 3995941 gattgctata ttttatattt attcacttgt atctcttcat aaccttgata ttaattccgt 3996001 tatcaataaa agatttgtta tgatgacact catgtattat ctaaccttac ttaacttatt 3996061 tagttttcaa ttatttatgg agctttatta taaatctcaa atagcacaat taaatataag 3996121 cgtttatatt attttttcgt taattttagc aaagaagtta gtgcaattaa attctccgaa 3996181 agttattcac tactttttaa ttccaaacta cagtaatgga ttaagaactg ggttaagcta 3996241 ttattcccaa tctggaactg ctattattga accattatta ggtttgttta ttataatcat 3996301 tttacagatt tcaatagtta tattatctgt cttaaagttc aaaaaaatag atatgctaaa 3996361 aagtgagggc ttacaatgat tgaggtatta aacctaacaa aaaaaattaa aaagactaca 3996421 gttttagata atatctctta tacatttgaa aaaggaacaa tttatggact atttgggagt 3996481 aatggttctg gaaagaccat gctacttcgt gcattatccg ggttaatagt ccctactgaa 3996541 gggagtataa ctattaaagg tgaacaatta cataaagata tctcttttcc taaaagtgta 3996601 ggattaatta tagaaaatat gcagttactt cctcagtatg atgcttttac taaccttaaa 3996661 attttgtcaa aaattaaaaa gatcgcatca gataatgata tattagattc tattagtaga 3996721 gttggtttgg aaaattttaa tagtgtaaag gttagtaaat tctcgttagg aatgaaacaa 3996781 cgattaaata ttgcacaggc tatttttgaa aaacctgata tattgctact tgatgaacca 3996841 acaaatgcga ttgatgaaaa aggagttgca tttgttcatg acattctttt acaagagaaa 3996901 aaaaggggag ctaccattat tattactagt catcacaagg aagatattat atctttatgt 3996961 gacattgcat tagaaatgaa tcatggacgt ctagaaactt cagaaaaagt aatatataag 3997021 aaagatagtt agtttaaact ggctatttct tatccaatga tagactgcag acaagttcaa 3997081 ctgctgtaat gctagaaaat ccaatgaaat gctgataatt gcgaagagat atgatcagtc 3997141 agaaaacaaa tcttaaaaag aaaaagtaaa ttcatcaata tttctaataa acctggcaaa 3997201 caacctgttc ggaggcatta tagctacttc actgacggga tatttatttg atgtgacagg 3997261 ctccttacgc tcagctttct ggtgccggtt ttgtgttgtt gctgggattg gttttttatg 3997321 tgtttgtatt aggggatgta aaacgaatta aactggaata aagagtgctt gctgaaaagc 3997381 actctttttc tgcatcgaaa gaatacttaa gataagtcac tcccaaaaat cgtaacagtc 3997441 tgacggttaa acataaacct ctgcccgttc cattttaata cggtttgaac atatcccaat 3997501 gagtcggcgt tataccttcc cgctatccgc tggtacgcca ataattcgta tacgccgtct 3997561 ctgtcaaaat caaccggata caagcccgat aaaggattca cccatccttc tatcggcatt 3997621 tttaacacac cttggctgtt ataaatctca ttcaaatatt ccctgccctt gtaagtaagg 3997681 tcgaggatat acgtttcgtt ttgctgatga ctgataacgc tcgctttata ttgattttga 3997741 tacctcacac tgtactttaa ttcatcattc aatacatctg aattgaaaat tcgccggaac 3997801 tgcctgttta gataggcaaa cacatatgca taaatagcac cgccgcttcc ccctgtgtcc 3997861 attactactg ccacatcctc aatcttgtcg cctgtcatat cccccagaaa aagtgacgga 3997921 ttgtatccca tattgttttg aagctgaatc cgctgctcct gatgggttct gccatcacgg 3997981 atcaccaatg tgatatttct ccataacggg ctgccgggca tttgatttcc agttagaaag 3998041 acctcgtcaa taacgccgtc tcccgttaca tcgccgcggg tagatacaat gattgcacgt 3998101 gaggagacag gctgccgaaa tacgtatgga tgttgaacaa gtcctctgcc ttcataaaac 3998161 caataaggag ccattctgat gtcatacaca ttcaattgtg tcaccttccc taatcagctg 3998221 aatgaatcat tatatgcagg aatggcacat caaagacata tcttacacac caattaaatc 3998281 cgtaccatat gaattatcaa ttacacaaag ccactcgcct tgcgcattct ttttaaatac 3998341 ataggtcgcc cttctttcca tcgcatactc ggagtccttt ttatccgaat caagcagtgt 3998401 ctgagaaaga acgagtaccg tgtcacctgc ttccaacagg atcattttcc cttgtgtcgg 3998461 gacaatatga tgattgaaat agttcgcaat cgtgataaac gcttttttga tttcttcctt 3998521 gcctcgcgcg atcatgcccg gcttcacaac taaaacggca tcttccgaat aataattcat 3998581 cagtgtatca aaatcttcat tttggattgc caaatcacac gcagagatga tgtctttcaa 3998641 ttgctgttcc aaatgaattc ccccaatcat catgattgga tatattatac atcgctagac 3998701 cactgaaacc ttgaaaacaa aatgaaaagt atcctttttt cctatataat caaatagata 3998761 tatttaacaa agtacccaag tgaaggggtg aacattattg tctgcggaag taacgttaca 3998821 tgacaatata cattatgatt taagtgcgga ttgccagcac tgttttggcc tgtgctgtgt 3998881 cgccttgcct tatgcgaagt cggcagattt tgcttttgat aaagacgggg gcacgccttg 3998941 ccgcaactta caatcaaact atcaatgttc tatacataaa gatctcagag aaaaaggatt 3999001 tcgaggctgc tctgcatatg aatgctttgg cgccggccaa aaagtatccc aaatcactta 3999061 tgagggaaag gattggcgaa acagccccga aacggccaac cagatgtttg acgtttttcc 3999121 tatcatgcag cagctgcacg aaatgctctg gtatttacat gaagctcttt ctatagatat 3999181 agccaagccg attcattctg aactgagaac cactttcgaa aaaatagaaa ggctcaccag 3999241 actcagcaaa gaacgcttgc tgacactgca ggtggacgag catcgagctg aggtcaatga 3999301 atggctgtta aaaacaagtg aactggtgcg tgcccaagcc cgccatccaa aactcccgaa 3999361 aaaggtcagc cggggaagtg tcctgatcgg cgcgaaactg aaagggcttg atctgcgagg 3999421 agcaaatcta agaggggcgc tgctcatagc cgccgatctg agaaatgccg atttgagaat 3999481 gacagacttt atcggtgcag atatgagaga cgctgatctc agcggcgccg acctgaccgg 3999541 gagcatcttt ttgacacagg cacaggtgaa cgccgccaac ggcgattcga atacaaagct 3999601 gccgctgtct gtacgaaccc ctgcccattg gaaataaaaa aggacccgct aacggtcctt 3999661 ttttactgat caattcaatc ctttttcgtt cctcttatcc ggcattttca cacttcttgc 3999721 caagtatccc gacagccata acgcaaccag cagcatgaag gtgatcatac cgacgacgcc 3999781 cagccagtga aaaccagacc agaatagccc tccgattgtt ccgaaaacac ttgaaccggc 3999841 gtaataaaag aacaaataca gcgatgaagc ctgtgctttg ttgtgaaggg ctctcctgcc 3999901 cacccagctg ctggcaactg aatgccctcc gaaaaaaccg aatgtaaaga gggcaatccc 3999961 cagaattttc actgccagca tattgtttat cgtaaataac gcacctgcaa tgacgatgaa 4000021 aatattcatc accaatattt tcggatagcc ataccgatca accattcttc caatgaaaga 4000081 cgagctgaaa atgcctacaa tcatcacaat aaagatccag ctggaaaatg ctttattaag 4000141 cgaatacggc gggcccaaca gcacatacac aatgtaatta aacaaggcaa cattgcttcc 4000201 aagcagcaaa aaaccaatga gaaacaagct gaatagttta cggtccctca agtggccgat 4000261 cagagacatt cccaatttcc cgagcttcaa ttttcttggc gtaaaatgcc tggatggcgg 4000321 caaatttata aaaaatataa cactagcaat caaactaatg acaccaattg tccccatcgc 4000381 catatgccaa ttcaagtact cgctcaggag cccggaaacg atccttccga aaacggcgcc 4000441 gattgcattt ccgctgatat atagccccat cgctgatcca agacttccgg gttcaatttc 4000501 ttccccaaga taagccatcg caatcgacgg aaggcctgcg agcgcaacgc cttgaatggt 4000561 tctcaatacg agcagtgtat gaaagctcgg actaaaggcc gatgccagac agagaaccga 4000621 tgcggccagc atggaaatac ccataatagg cttgcgtccc cacacctcgg ataatgaacc 4000681 aaagacaagc atgctcacag ctaacagcat tgtggtaaca gataaagaaa gactcgccgc 4000741 agtaggcgtt acatgaaatt cccgcgtgaa ttcctccatg agcggctgta cgcaatatag 4000801 aatcgcaaat gtattgaaac ccgcagcgaa gaaagcaaac gtaatttttc gaaaaaccgg 4000861 tgtgcctttt cgaatgtatg tcatcgggac tttatcggtc cctcatcatg ttgtggagca 4000921 ctgccattca taaacaatca tcctttattt cttacgaatt caaacatcct cgagtctgtt 4000981 tatattatta tcttagcacc gttgatatat gttgtataat gcatataaaa tatccttttc 4001041 atgcttatat gtaataagga gagatgataa ttggaatggg aacaacttga atattttcaa 4001101 acactggccc ggatgcagca cgtcacgaaa gccgcaaaaa gcctctccat cacacagcct 4001161 gcactttcac gctctatcgc caggctggaa aatcatttgg gcgtcccgct atttgacagg 4001221 caaggacgat ccatcagctt aaatcaatac ggacacattt ttttacgacg ggttcaggcg 4001281 atgatgaagg agtataccga aggaaaagaa gaaatccaag ccttattaaa gccagaccaa 4001341 ggcgtagtct ctctcggttt tttacataca ttaggcacca cgctcgtgcc cgatctcatc 4001401 ggctcctttc agcaggaata ccccaacatt tccttccagc tgaagcaaaa ccactcttat 4001461 tggctgcttg aacgattaaa atccggagat ctggacctct gtctcctcgc ttcgattaag 4001521 cctgaaaatc cgatccaatg gatcaagctg tggagtgaag aactctttgt atttgtgcca 4001581 aatgatcacc cattagccag tcgcgaaagc attaccctga atgagattgc cggggagcgt 4001641 tttattttat tgaaaaaggg ctatgcgctt cggatgacgg tcgatgagct gtttgagaag 4001701 gccaatatac agccgaacat tatgtttgaa ggagaagaag caactactgc cgcaggtttt 4001761 gtggcagccg gtctgggcat atctattctc ccagacctga aaggcttaga ccaaagcaaa 4001821 atcaccaaaa tccgcgtcag ctggccggaa tgtcagcgtg tcataggaat tgcctggata 4001881 aaaggcaggt ttttatcacc ggttgctgag acctttaaac aatatgtgat cagccatttt 4001941 tctgagtagg aaggattcaa gcatgaatgt caaaaaaatc acgtcagaac aggatttaca 4002001 tacagcgttt gaaatcagaa aggcagtatt tgtagaggaa caaggctgtc ccatttcgga 4002061 tgaattcgat gagttcgata cactccacgg tgactgccag cacatcctgg cttatcatca 4002121 gaatgtacct gttggcactg cacgtgtccg tatcgttggc cacacgggga aactggaacg 4002181 aatctgcatt ctgaagtctt accgcaaatt cggtttggga aaagtgatcg tcgatgcatt 4002241 agaacgtatt gtaaaagaac aaggcatttc tgccttcaaa ctgcacggcc agacacaggc 4002301 ggcaggcttt tatgaaaagc tcggctatcg gactgcatca gaagaattta tgctggacgg 4002361 cattccgcat gtgctgatga caaaacaaga cgattctgcg ctatagattg ttcacaaatt 4002421 tgtcacttat gagcatgaac ggttcattgg tatactaatc accgattatg gagagaagga 4002481 atgattgtat gccagcaaat aaaaaagaag gccttatatt tggcgtgatg atgtgctttg 4002541 gaatggtttg cgtcatgtcg atttacaatg ccatcatcaa ccgagccatc tacgattttt 4002601 cactgatgac cgtttttgaa atggtcatcg gttttatgat cgccctcctg ttagatttac 4002661 tgttagtggg ccccctcgcc aagaagattg cattccgcat gccgttcgac aagactaaaa 4002721 aaatttatgt catccttgcc atgtcaactt gtatggtgat tggcatggta ctttgtatgt 4002781 ctgtgttcgg tttagtgaca gcggttctag caaatgggct gaacggggac agcctcttca 4002841 gtgcttatct tatgattgtg ttgaaaaatt tcatcctggc ctatccgttg caattactga 4002901 ttatgggccc attagtcaga ggagttttca tgaaatttgt aaaaccaaag ctcacagccg 4002961 caatttaaat agaaaaggag tgagcctgac actcactcct tttgctcatg aatcgaatgt 4003021 aaaacaagct ccgcaaaagc ctctgcggca ggcagctgcc attttttctt tttgggtgtg 4003081 agtaaatcgg atcgagggct tcaccatgct ggagattttt cagcttatgt ttttcacttc 4003141 cattaatccc tataccttac cacatagttt ttatacaatt cttcgttata aaggatttct 4003201 tcgccatgtg aagagcaaat gagcgttggt ttgatttgat ctatgattga gccgctgtcg 4003261 atgttctcat ttatatcaac actgaatctt cttataggtg ggtgtaaatc ctccttactt 4003321 gtgataaaaa ggtcgcccgt caatagcgta cgatcgattt tatgataata cacaacatgc 4003381 cccggcgaat ggccaggtgt taaatagtat ttcagaggca gatgagcaag cgtttgctcc 4003441 gtcagcggct gtacaatatg ggctacccct gtgttctcca cttcattttt gttcggatat 4003501 ggctcttccc cattgatgta ctttagttct ttctggtgcg caaaaatcgg aatatcaaat 4003561 ctctctaacc attttgatgc acccccgata tgatcactgt ggccatgggt aagcaaaatg 4003621 gcttttggat tgccgatcgc taacgctgcc ctaatttgag catcagcaaa acgttctatt 4003681 cccgtatcaa caatataaac atcatcacca tctttgataa accaggtatg aaccggaata 4003741 cgaagaggca catcaagctc aaattcacat tgaaagacat gttctgatag ttgtctcaaa 4003801 ttcacgcaaa ccatctcctg tggaaatttt ttgatagttt taaagaaaac agaagtgaac 4003861 ggactatttt cacccacgct cgagctgact ggattcttga gaggaaacgc cgattttcgc 4003921 cagcatcagc tcaacttgtt aacgttgtcc attaataatc ccttttgttc cccttcttca 4003981 catattccca atcacgttct atattcttcc tcactctatg aaggagtgca gaaatggttt 4004041 ccttttcctc tgaagtaaaa ccggacaagg ccacttccgt ggaatgttct ccttctcttc 4004101 ttaacaatgg atataccttt ttccctttct cagtcgggaa cagttttttt atttttttat 4004161 tttgctcatc cggcagtttt tgaataaatc cctgcatttc cagcttctta atggcccgcg 4004221 cggccgttgt ccggtccact tttatcattt ccgccaattt ttcttgaata attcccggat 4004281 tttcgtatat acgcacgaga tagagatact gccctcttgt taagtctaaa tctttaaatt 4004341 cgatgttgct tatggaatcc aacgctcttg ctatcatgcc gatctcacgc aaaatatcat 4004401 tcattcctaa aacccctcac gtatttttgt tgcaattaca acaaaaatgt tttaacctta 4004461 ctattataag accacatgcg tgctgtacag tccagactaa tatcagaaaa ggattgattc 4004521 ataatgaata taaaaagaat aacaactgaa gctgatttac atgaagcttt aaagattaga 4004581 agaggcgttt tcattgagga gcaacatgtg tctgaagccg atgagttcga tgaatttgat 4004641 acgcttcagg aacaatgcca gcatatcttg gtatatcatg agaatcagcc tgtcggcacc 4004701 ggacgcgcgc gcatcgttgg ccatacagca aagctggaaa gaatctgcat cctaaaacct 4004761 taccgtaagt acggattggg gaagatcatc gtaagcgggt tagaggaaat catgaaagaa 4004821 aaaggactga cttcatataa gctgcatggt caaacacaag cggcaggctt ttatcaaaaa 4004881 ctgggctacc agatttcttc acaggaattt atggaggacg gcatccctca cgtcttgatg 4004941 acaaaagaaa tatcgcggaa tataacatga aatatatgta ttacggaata ggcatactca 4005001 tattaagttt gggcatttcc ttaaccatac aatcaggact gggcacatca cccttcgatg 4005061 cccttttggt tggtctgtca aaaaaaatcg gtcttaccgt aggaagctgg gaggtcctta 4005121 tttctgtgat cctcttaatc tgcaacgcta tattaacgag aaaaaaacct attttgctgg 4005181 gcttgattac agcattcatt actggaatag gcattgacct atggttgttt gttgtaaaaa 4005241 acaccatcta tctaaactcg ttgttaagca aactgatttg ttttggaatt ggtttggtgc 4005301 tcatcggtct tggaacagcc atctatcttc agacgaaatt cgcatcaaca ccgatcgatc 4005361 atttaacact tattatccga gatctctcca aaagaacaat attgttttca aggacattgg 4005421 tatacgctct tttcttagta ttagccatca tctttaaagg ccctatcggc atcggaactc 4005481 ttttaacggt ttgtttggga ggaatgctcc ttcacgtttt tatgcctatt gtggaaagac 4005541 atttcttatc aaagaataga agaggttatt aagaaacctc ttctcgatcc aaaaaacgaa 4005601 acgcaaaaca agccccgttt cgttgtcaat tctttatctc tggtactgtt gaggttttat 4005661 aatcaattaa aatttatagt accaaaaaat cgcaatttca tttgctgttg gaaagttgga 4005721 ataaagcatc gtatcaaccg cacctattat aaagtgatgt ttggcataaa aatgacaagc 4005781 tgaaatatta atatcttggg tttcaagcat aagaccacaa aaatgattct cctttgccca 4005841 ctcaatcgct ttatgtaata atgctgttcc aacacctttt tttctatagt cttttgccac 4005901 ggcaatgtcc tctattagtg catacccatt ccagttagaa cggatcttaa tccggccaat 4005961 gcagttgttt tcaagataat ataaaaaagc cgctttcccc tcttcttcaa cataactaac 4006021 atccatgtca tcatcttcat attgtttaaa ataaggttta gaaaatcgtt cctcagtata 4006081 tgtccaaaca ccgttttcaa aagcaggtat cattctccca aaaacaacga aaggttcgtt 4006141 tggtttattg aaatctttca tattcaaatg agtcattttc atgatcatat caatctccgc 4006201 caatcgagat aatatttagt aaactcgttt cgatactatt caacaacagc ttccaaaagt 4006261 gtactcttta agagaacagc attagataag gcatccatta ccttatatat ttcactatct 4006321 taatgaggta tttcaacaga ggcttgtggt acagtaaaaa ggaatagaaa caagagaaaa 4006381 gaagatgaac ctatgcccac taacaataaa ctcaatgaga aatatcatac ttccttcaac 4006441 tcgcccacaa ccctgttgac tagtatccgt ggagagagga agctttgaca cagcttctgc 4006501 cattgatgac atctctattg aagtatccaa aggacaacca aggatcgctc tttgactttt 4006561 tcaagaagaa agtagagtga ataaaggagt gattgagtat gttaacaaga gaagatatct 4006621 ttaaacacgt caaagaaaaa tacggtacat cgcctgatta cccgtgggag aaatacccaa 4006681 actatgcttc tttgagacat acatcaaaca aaaaatggta cggtcttatc atgaatgttc 4006741 tcccagaaaa attaggcttg gatggtcatg gcgaaataga tattctaaat ctaaaatgtc 4006801 cccctgaaat aagtgatcgc ttaagaaacg gggaaaatat cttacccgga tatcatatgg 4006861 ataaggaaca ttggatttca attgttttag aacggacaga tccagaaggc gaaatctata 4006921 acttaatcga gcagagcttt catttaacca agtgaagata aagagtgttc ctgctaatca 4006981 agctgcgaag agtagtgggc actttcattt taggatactg ttcttcactc tgtccacaaa 4007041 cgcaacttag ttcatctggt gcgagagtgg gagaagaatt tcaaccaact tcttatgtaa 4007101 aaggatgaat agttatgaca aataacttaa aacagagaag aatcatttta gatttagcag 4007161 ttactttaga tggttttatt gaagggaaaa atggagaagt tgattggtgt attatggacc 4007221 ctgatatggg gtttactgat tttttaaatc aaattgatac tattttatat ggtagaaaaa 4007281 gcttcgattt atggggacaa tacattccaa aaaatgaaga ccctgataca gaaaaggaac 4007341 tttggaaatt ggttcatagt aaaaagaaat atgttttttc cagaacacaa aatgagattg 4007401 ataatcaagc catatttata aatgataata ttcttgaaga agtaaataaa ttgaagaaaa 4007461 atcctggtaa agacatctgg ctatatggtg gagcgagtct cattacaact tttataaatt 4007521 tggggcttgt tgatgaattt agattatcta ttcaccctgt tgttttggga gaaggaaaac 4007581 cgttgtttat tgatgtaaaa cagaggataa atttaaaaat ggtgaataca agaacatttt 4007641 cctctggcgt tgtgcaaatc gtttatcatt ggaatggcta acattgtaaa gtaacactcg 4007701 acagtaatcc ttcttattga actaaagggg aatccataaa taatgggttc cccttaatat 4007761 actatggaat tatcaatatc aaattttctg taataaaaga ggattgaaaa ggacgatgtc 4007821 tcctcaatta acatcattaa gcattatagt atattttctt ctccctcttt taagtaatcg 4007881 gctaagtttt gtatttataa aaaaacgaaa gaaggtgatc caatgcctac taacaataaa 4007941 cccaatagat taatcgctga gaaatctact tattttactt caacatgctc ataaccctgt 4008001 ggactggttc ccttggggag aagaagcata tgaaaaagcg aaacgcgaaa acaagcctgt 4008061 tctcgtatct attgggtata gctaacgatg gctaatctaa agaacatgct attgatgcca 4008121 tgtttattca ttttacaaaa aaggatcaac cttgaattac tttcacaaga ttgatccttt 4008181 cactcattta gccatgtctc cgcgaacgtt tatatacatt caagattact agccaacaaa 4008241 taacaatgat tcctgcaaaa agtatgagca tattgctata caaataggta gagtgatcaa 4008301 cgtcaatagg cagcagccta tgatctagga agccgataga taataaaccg cctacaatcg 4008361 caatacccgt tccctctgat aaaaagctcg tgaaattaag caaactcatt ccagcgcccg 4008421 cttccttttc tttcaaactg ctagacacaa ctgtagatat aactgttttt gtgaaagata 4008481 gccccccaaa aacaaaaatt actataattg tcatgatcca tggtgctgca tctataaaaa 4008541 aggcagcgat taaaaagccg gaagaaagca atgcacttcc aatagttagt acatacaagg 4008601 aacctttccg atcaacaagc aatcccccaa tgtaaccaaa gatgatgaca ctcattgttc 4008661 cggggaaaat aatgccgctt ccaattgctg cagtacttaa atggtgaaca tctttcatca 4008721 tgtaaggaac catagagaca aatcctgcta ctgtaccaaa tattagtcct ccgcaaaggg 4008781 ttccaatcac aaaaaagacg tttttcccta attcagggtc aacaaaaggg tcctgagctt 4008841 tcctaatgtg ttgcacaaat atgaagaaag caaggatact gatgatcaga aaagaaaatc 4008901 tataagatgt tgtaaacagc ataaaaaata cgatacctgc agacatcaat ataatccctg 4008961 ccatatcaat gtgtcctctt attctctctt cctttttcaa caattttata aggaatggaa 4009021 cggtgataat tgttgcagtt ggaataagca gcaaatacga ccaatggata taatgagcaa 4009081 ccattccgcc aatagctggc ccaacacctt ctcccattgc taccagggac ccgatcaggc 4009141 caaatgcttt ccccctgttc tcttttggaa tatagcgcgc aacgacaacc atcacaagag 4009201 ctgggaatgc ggctgcacca attccttgaa taaatcgggc tagaatgaga ataggaaaga 4009261 aagagtgtcc aacaaatcca atgatcgacc ctaagccatt taccataatc ccaaatagaa 4009321 gcagattttt gatgcccagc tggtctgata gctttccata tagagctgtt ccaatggaga 4009381 aggttaacat aaaggctgta ttcacccagt ttgcacttgc tggcagttta ttaaactcgt 4009441 tggcaatatc aggtaatgag acgttcagaa ccatttcatt taatacgctg aaaaatgata 4009501 gaacacaaag ccaaatcaaa acttgattgt gccgtaaagt tgactgtgaa taagacgtat 4009561 tcacaatttc ccctccatta atgagggcag acgcagttta tagggtcatt gatacgcttc 4009621 cctcttttaa ttgtaccctg ttcattttat tgcacttcat aataactccc cctacatttg 4009681 attgatatga tcttattata tatagactaa ggattaaact tttacttttt ttataaaaat 4009741 ttgaccagat tgcgaaacaa ggaaaaacgt tattcgcatt tatctcaagt ggcaaaatga 4009801 aacattagtt tatattttca catcacaatt atcgataagc agtcagttat tgtatttgtt 4009861 taggataact gtggtaacct gaatataacc aacttaggaa gaaggtgatc ccatgccaaa 4009921 taaaagtaaa cccaatagat taatcgctga aaagtctcct tatttactcc aacacgccca 4009981 caaccctgtg gactggttcc cgtggggaga agaagcattt gcaaaagcaa aacgcgaaaa 4010041 caagccggtt ctggtcagca tcggttattc gacgacttgt cattggtggc ctgggataat 4010101 caaatcgtgt ggaactccat taaaagataa cagaagccat tttaaacgat aatactattt 4010161 gttcaaacaa tacagtctac cttttatttc attcattttc taaaacctgt aatccgtaac 4010221 cacgcggtag caggtttttt tatttgcttg acttagagtt aactctaaat tgtaaactaa 4010281 ctttaattaa atgagaggga tgatgttgtt gtattccatt agtaaagctg ctgagaagac 4010341 tagtattagt tcgtatacat taagatatta cgaaaagatt gggttacttc caccaccaaa 4010401 acgaaaaaac agtggaaggc gtttttatac ggagactgat attcagttca tgttattcct 4010461 gaaaagttta aaggaaacag gtatgtcttt ggaggatatt aatgagtttg tcaaagacgg 4010521 atgcattttg gaaaaaatca attcggatgt taaatcggca caactctccc catctataaa 4010581 taaacgtatt gagattttaa ccaagcactt agagaaaatg gaaattaaaa aaagggagct 4010641 ggaagaagtg atttctacta caaaaggaaa actggataca tattattcaa ttttgaaaga 4010701 ggaagtggaa aacaaatgaa acatttaaat atatacataa tgttacttgg cttctctatt 4010761 ttcacgggag ctacttttaa tcttgcaaaa tatacagttg gatatttttc tccatcgtct 4010821 tctgcggcat ggcgtttcgg tttagcggct gcagtgatgc tcatcatttt gatttttact 4010881 gaaggtataa agaagagtca attacggaaa aacgccgttt catacattgt tcttggaatt 4010941 ataggaatct ttggatttaa tgccttgttt tttgttggtt taaaatatac atctcccgtt 4011001 aacggagcat taataatggg gctgaatcct ttattaacag caattctcgc tcgaattatc 4011061 ttaaaggaca acatgacaaa aaaacaagta ctcggcatat tctttgcatt catcggtgta 4011121 ttgttagtca ttacacaagg ttctatcgaa accattaaaa ccttatcaat ttcaggagga 4011181 gacttaataa tctttacagg taacgtttgt tgggcacttt atggcgtact tggacgtcgg 4011241 tttgtaaagg atggtacacc gctatctaca accacttata cgatggttat tggtgctgtt 4011301 agtttaatag tagtttcctt atttacatcc aaacctgttt ctttatcgaa catcccgatt 4011361 ggagtttggg gggcaattgc ttttatggct ttttttacaa gtgttttggg ttacctatgg 4011421 tggaatcagg ggattaaaga gattggagct agtaaaacat ctttattttt caaccttgtt 4011481 cccgttgtaa cgatgattat ttcatttgcc gttggaacac caataaaggt atttcaagtt 4011541 attggggctg tgctagttat attaggcgtt ttaaccgctt cgggggtaat acgtattcct 4011601 aagtacaata ctaaagaaca gtcagctata taaagaaata gggagtattt ttgagaaaat 4011661 gtgttaagtt aaatatacac taattatagg aagaaggtga tcccatgcca aacaaaagta 4011721 aacccaatag attaatcaat gagaaatcac catatttact ccaacacgcc cacaaccctg 4011781 tggactggtt cccgtgggga gaagaagctt ttgaaaaagc aaaacgcgaa aacaagccgg 4011841 ttctggtcag catcggttat tcgacttgtc attggtgcca cgtgatggcc cacgaaagct 4011901 ttgaagacga agaaatcgcg cgtcttctca atgaacggtt tgtggcgatt aaagtcgacc 4011961 gggaagagcg gcctgatgtg gattctgttt atatgagaat ctgccagctg atgaccgggc 4012021 agggcggctg gccgctgaat gtgtttatca cgcctgatca aaagccgttt tacgcgggta 4012081 catattttcc aaagacgagc aaattcaatc gtcccggttt tgttgatgtg cttgagcatc 4012141 tgtctgagac gtttgcgaac gaccgcgagc atgtcgagga tattgcggag aacgccgcta 4012201 aacatttgca gaccaaaaca gctgcaaaaa ctggtgaggg ccttagcgaa tcagcgattc 4012261 accggacatt ccagcagctt gccagcgggt ttgacacgat ctacggcggt ttcgggcagg 4012321 caccgaaatt tccaatgcct catatgctga tgtatttgct acgttatgat cacaatacag 4012381 ggcaggagaa cgctctatac aacgtgacga aaacattgga cagcatggcg aatggcggca 4012441 tttacgatca tatcggctat gggttcgccc gctattcgac cgatgacgag tggctcgttc 4012501 cccactttga aaaaatgctg tacgacaatg cgctgctgct gaccgcttat acagaagcct 4012561 atcaggtcac gcaaaacagc cgctataaag agatttgtga gcagatcatt acgttcattc 4012621 agagggaaat gactcatgaa gacggaagct ttttctcggc tttggacgcg gacacagaag 4012681 gagaagaagg aaagtactac gtgtggtcaa aggaagagat tctaaaaacg ctcggggacg 4012741 atctcggaac gctgtattgc caagtgtatg acatcactga agaaggaaac tttgaaggca 4012801 aaaatattcc taacctcatt cacacaaagc gagaacaaat caaagaggat gccgggttaa 4012861 ccgaaaaaga gctcagtctc aaactcgaag acgcaagaca gcagctcttg aagacacgcg 4012921 aggaaagaac ctatccgcat gtcgatgata aagtgcttac ctcatggaac gcgctgatga 4012981 tcgcgggtct tgcgaaagcg gcaaaggtat accaggagcc gaaatatctc agcctagcga 4013041 aagacgccat cacatttatt gaaaacaaat taatcatcga cggccgtgtg atggtccgat 4013101 atcgtgatgg cgaagtgaaa aacaaaggct ttatcgacga ttacgctttt ctcctatggg 4013161 cttatctgga tctctatgaa gcttcgtttg atctttctta tttacaaaaa gcgaagaaac 4013221 tgacagacga tatgatcagc ttattttggg atgaggagca tggcggattc tacttcaccg 4013281 gacacgatgc agaagcctta atcgtacggg aaaaagaagt gtacgacggc gccgtgcctt 4013341 caggaaacag tgtggcagct gttcagctgc tgcgtctcgg gcaagtcaca ggcgacttat 4013401 cactgatcga aaaagcggaa acaatgtttt ccgtgttcaa gccagacata gaagcgtatc 4013461 cgagcggcca tgctttcttt atgcaaagtg tgttaaggca tctgatgcct aaaaaagaaa 4013521 tcgtgatttt tggcagcgca gacgatccag ccagaaaaca aattatagcg gagcttcaaa 4013581 aagcctttaa gcccaacgac tccattctgg tggcagagca gcccgagcaa tgcaaagaca 4013641 ttgcgccatt tgcagcagac taccgcatca tagacggcaa aacaaccgtt tatatttgtg 4013701 aaaacttcgc ctgccagcaa ccgacaacaa atattgaaga agcgatccac acattaataa 4013761 gcagcaggga ttaagaccct tgctgcttac tttttgattt cttatggtac cataaagcga 4013821 tccccgcaaa cacaaggttg accgctatcg taaagaaagc ctcccacatc gggttccccc 4013881 gcgtaacggt aaacagagaa ggaattcctc catacacact gtttttttct gtaataaaca 4013941 tacacaaaaa catattattc gcggcatggg cgccaagtga tatttcgatg ctcccagttt 4014001 taatcgtgta atacgtccac acaaacccaa atgttaagta ctcaattcct gcccagacag 4014061 cgccattgtt catttctgga ttcgcaaaat gcaatacgcc aaacaatcct ccgacaatca 4014121 gtgtcaaaaa tagaggattt ttcgtcaatc tcccgaaagc ttgaagcaaa aatcccctga 4014181 aaaatagttc ctcagctgat gtctgaatcg gaaccaaaat gagggcagcc gctagcagcc 4014241 agataaatcg tgatgcatta aactcttgca ttgaatagct atcaggatga atcacaaaat 4014301 caatcaattg tacggcgatc attagcaaga aataagcaat aaaaccaaag gaaattctcc 4014361 gccaattcat ctttgaattt ggtgttatca ccgttcggaa aggccgcttc aaaataaagc 4014421 gcacagccag ccaaactccc ggaatggcga ataaataaat cacatgggac aaataaagat 4014481 ctacgagggg atcactcagc acagcttcat ccaaatcaaa cgtgatattg ggattcacaa 4014541 taaccgtgaa caatatagcg aaaaggtaag ctatattccc taatacatat aaccctacca 4014601 tcaccaaaaa agcgaaaaaa tatctccaca acgtattgtt tccttctata ggacggataa 4014661 atgaattcat tccttctatg tctcttcctt tcaatgagaa tattactata tatttgcata 4014721 aattggtcta tgaatctact gttttggaaa tcttttaagc aaaattaaaa tataaagtgt 4014781 gaatttagtt cttccatcta gtgatttgaa ctctgttgcc aatgaaccaa gatacttata 4014841 atagtcccaa gaggggaatt ttcagtcttt tctactactc aaaagggggt tttttatgaa 4014901 tacgatcttc aaacaaaaga atacacatcc tttctcaaac gcagcgaatc gtttagaccg 4014961 ccttccgatt tcacgcgttc atttccaagt gttaaccgct ctcggcattg tttatttctt 4015021 tgatctcgca gatttattta ccctcagcaa cgtagcgccg gcactgatcg agcattgggg 4015081 catcccgctt tcaactattg ctaacgtaac ggccgcttcg tttttaggca tgtttttagg 4015141 cgcttcactg ggcggacggc tgtccgatcg aatcggccgc aaaaaagcct taaatctatt 4015201 tgtctttgtt ttctcaatcg catcgctatg caatgctgcg gcatgggaca ttccatcttt 4015261 aatgacattc cgtttcctca ccggatttgg cgttgcagcc gccatggtca ttacgaatag 4015321 ctatttggcg gaatttttcc cttcaagtgt acgtggaaaa tatatttctt tttgtgccat 4015381 gattggattg attggggttc cgatcaccaa cattgtgtct gcctttgtca ttcctcttgg 4015441 ttcatgggga tggaggctag tatttgtatg gggtgccgtc ggccttattt attttttctt 4015501 catccaccgt ctggaagagt cacctcgctg gcacgaaaat cgcggggaat atgcgaaagc 4015561 cgatgcgatc ctcacccgaa ttgaagaaca ggttgaaaag gagaaaggcc cgcttccggc 4015621 agcatcccag cctaaagtaa gcgaaactgt taagcagaat gcaggttacg caggcttatt 4015681 gaaaggcaga aacctcaaaa ttaccatcgt attatctgct gtatggattt ttgaaacgtt 4015741 tgggttttac ggatttgctt catgggttcc aagcctgcta aaaagcaatg gcgtaaccat 4015801 ggaaaataca ttatggtata acgtattgca ttccgtcggc gctccacttg gcgcactgct 4015861 cggctccatg atttccgaaa gatttcaaag aaaatggatt ttagctgcga gtgcgtttct 4015921 gacggccatc gccgggctct tatatggtat gacttttatt cccatcatga tcattgtatt 4015981 tggttttatc gtgaatatca cagaacgggt ctttacctcg aacttatacg cctatacatc 4016041 tgaaccttat ccgactgaat accgctcgtc tggcagcggt ttagcctatg gtcttggccg 4016101 tttttcaaac atttttggct cattgcttgt cggatttatt gccgttcagc tcggctatat 4016161 cagcgtcttc ttatttattg ggggctgttg gctcgcatgc tccttgctgt taatcttctt 4016221 cggtcctaat acgaatgcaa aacagattta aaaaagtcag tgcggatctg ccgcactgat 4016281 ctcattacaa ttgcttcaaa atccttgcgg ggtttccgcc tacaacagta ttagcgggta 4016341 catccttagt gacaacagat ccagaagcaa tcactgcgtt atcaccgatt gtcactcccg 4016401 ggttaatcac cgcccggcct ccaatccaaa cttgatctcc aattgtcaca ggcttaccga 4016461 actccttccc ggatttcctt tcgatcggat caagaggatg accggccgtg tagatatgta 4016521 cacctggcgc aatcaaacaa tgacagccga tacgcacctc acacacatct aaaatgacac 4016581 agtcaaaatt aacaaatgta tgatctccga tatgaatgtg atagccataa tcacagcgga 4016641 atgtcggcaa aatcgtgact tgatccccaa ccgaaccgag cagctccttc aaaagcttcg 4016701 tccgcactgc atcatcttcc ggtgtttcgt tgtattgtct aatcagctgt ctcgcatgct 4016761 tgcgttctag taatagttgt tgatcttccg aattgtataa ttctccggct gccatttttt 4016821 ctttttctgt cctcagcatt taagtcactc cagatgtcag attgtaatct cgatcaaatt 4016881 tccttcatca tcctcaatca cgctttcata gtagccgtct cctgttgtcc tcgggccgtt 4016941 tactactgcg aaaccatccg ccttcaatcg atcagtcagt tcgtcaactt tctcccggct 4017001 cccaacggaa aaggcaatat gtgcccagcc tgtcattgtt tgtgagggcg gatcggtcac 4017061 attccctttt ttcataattt ccagccttgc tccggaatca aacgtaataa aataagactt 4017121 aaaatctttt ttctcattat gatacaaatc attcgcttcg ccattaaaat acgattcata 4017181 aaaagacttc attcgctcta aatcattgac ccagaccgct gtatgttcaa tctgcatttc 4017241 ttcctcctcc ttcgccttca atgaagttat aaggtatgaa atgcatttca gttcaagctt 4017301 ttttcttaaa tttatgctga attttgatat cagcgggttc atcctgcaaa aatagagaaa 4017361 atgctgcgat gccgagctgc tcaagattca aatcaagcga cggaaaacca agaacacggc 4017421 tgatagaagt atttccctcg cctatgattt caacatccca attattcttt ttggcaaata 4017481 gatgaattcc agctgccact tcatcactat ttgcataaat agcagtcgga acccgcccgc 4017541 tcatataaaa atgttcagct gccagctcac catcattcat atcgttgcat ccggacagca 4017601 tatggcggtc ttccaacctt ccgcagacag ctttataggc cgcagcttta tcagccgtgc 4017661 tcgggctcct atcagcttct ctgacacacg taaaagcaat attctcatgc ccgcggctct 4017721 ttaaatagcg aaagctctct gcataagcag tttttctgtc attaaaagca caagggacat 4017781 caatgtctcc ggtatcctca caagcgatga ccggcccata ttcctgataa gctaaaatgc 4017841 tgtcccaatg attggcgcgg gaagtaatga tgagaccgtc tattttcttc gttcttaaca 4017901 gctctaaata tttgatttca atatcggggt tataattggt ggggagaagg gtcgttgcat 4017961 actcatgctg aaaagccgcc ttggtgattc cgttaacgat tttatcaaag cagggatgat 4018021 cgctataagg cagaatcaca ccgaccgtat gggttttccc gcgaatgaga tcgattgcgg 4018081 ttcgatttgg tgtataatcc aattccttca tgacttgatg aacaagcttt ctcttttctt 4018141 cagatacata cggatgatga ttcaatacac gcgagacagt cgaaacagat acatttgcca 4018201 gtcttgcgat ctcttttata tttgccatct ctttctcctt ttcatataaa aaaagcagta 4018261 agtgtaaaat ccttactgct atctcatcat atattgatga taagttcaac aggacaatgg 4018321 tcggaaccca tgacgtccgc tgatatgctg gcatcttcaa tctgttcctt aaggctttca 4018381 gaaacaacaa aataatcaat ccgccatcca atatttctgt cccgggcgcc ggcacgatac 4018441 gaccaccagg aataagcgcc ttcaagatca ggataaacat gacgaaaaga atcaacaaag 4018501 ccagcttcta agaaacgagt gaatgcctct ctttcttgat ctgaaaatcc agcgttattc 4018561 cggttcgcct ttggattttt caagtcaatc tcctgatggg ctacattcaa atcaccgcat 4018621 aaaatcactg gttttttctg atccaattca agaatataag acagtaaagc ctcttcccat 4018681 tgcatgcggt aatcaatccg ctctaatccc cttctggaat tgggcgtgta aacagtcatc 4018741 acaaacacgt tttcaaattc cagcgtaatc actctgcctt cttggtcatg ctcttctact 4018801 ccgataccgt agatgacctg cagcggttct tgcttagaaa aaacagctgt gccggaatat 4018861 ccttttttca ctgcataatt ccagtacaca tgatagtctt caggctggag atcaacctgg 4018921 ccgtcctgta tcttcgtttc ctgaagacat ataatatctg catcctcttc tttcaaataa 4018981 gagaggaaat ccatttttct catcacagcc cgcaggccgt ttacattcca tgaaatcaac 4019041 ttcatgtttc atcctccccc ctataaaaaa gagcaagaac ccgaaggtcc ttgctcttta 4019101 catatcagct tactcaccgc ttacgtatgg aagtaaagcc atttgacgtg cgcgtttgat 4019161 cgctgcagtc aatttacgtt ggtatttagc gtttgttcca gttacacgac gtggtaaaat 4019221 tttaccgcgc tcagaaacaa actttttaag aagatctaca tctttgtagt cgatgtgcgt 4019281 gataccgtta gaagtgaaat aacacacttt acggcgtttc gcacgaccgc ctctgcgtcc 4019341 tcctgccatt gtcatttccc tcctttcttt ttcattttag gcgataatca cattagaatg 4019401 gaagatcatc atccgagatg tcaatcggtt tgccgtcgtt ggcaaatggg tcatcattaa 4019461 agctgttccc ctgattgcgt ctctggttgt tttgatttcc cccaaatgga ttatcatttt 4019521 ggcctccgcc aaagtactgg cctccgccgc tgtttccttc gttgtatcca cctgaaccag 4019581 aaccgccgcc gtttttcggc tcaagaaatt gaacactttc agcttggacc tctgtcacga 4019641 agacacgctg tccttgctgg ttttcatagt ttcttgtttg taaacggcca tctacgcctg 4019701 caaggcttcc ttttttcaag aagtttgcaa cgttttcggc ttgtcttctc caagtgacac 4019761 aattaatgaa atcggcctca cgttctccgg actggttcgt aaatgtacga ttcacagcaa 4019821 gagtaaacgt agcaacagcc gcaccgtttg gcgtataacg aagctctggg tcttttgtca 4019881 gtcttccgac taatacaact cggttaagca taagaaagac caccttttac cattatatat 4019941 ttcaaaattg cttattcttc ttctttaaca acaatgtggc gaatgatatc gtcactgatc 4020001 ttagctagac ggtcaaattc ttgaactgcc gcagcgtcag attgaacgtt tacgatttgg 4020061 tagaaaccgt cgcggaaatc gttgatttcg taagcaagac gacgtttacc ccaatccttt 4020121 gttccagtga tctccgcacc gttagaagtc agaacgttgt tgaaacgctc gataactgct 4020181 tttttagact cttcgtcaat gtttgggcgg ataatgtaca taacttcgta ctttctcatc 4020241 tgtttgcacc tccttttgga ctaagcggcc cataatgggc aaggagcaat aattctatta 4020301 ctcacaattt tatattatac caaagctctt gtccctttac aactgcatcc tatacattaa 4020361 atcggaaatg aataacatct ccgtcttgga ccacatattc tttcccttca aggcggactt 4020421 ttcctgcctc tttagctcct gccataccgc cgcccgcaag aagatcctca taagcaactg 4020481 tctcagcacg aatgaagccc cgctcaaagt cactatgaat aattcctgca cactcagggg 4020541 ctttcatgcc ttttttgaat gtccaagctc tgacttcctg ttctccggct gtgaaatatg 4020601 ttgcgaggcc gagaagagag taagacgctt tgatcagctg atcaagacct gattcttgaa 4020661 tgcccagctc ttccaagaac atttgctttt cttcgccttc aagctcagcg atttcagatt 4020721 cgatttttgc acacacaacg ataacttctg cgttttcgcc ggcagcgtac tcgcgaatct 4020781 tcgctacatt ttcattgcca gatggatcag caacttcatc ttcacttacg ttggccacgt 4020841 acaaaatagg cttcgaagtc agtaaatgga gctgcttcac aagcttttgc tgctcttcag 4020901 tgaattctac agatcgagca ggcttttcac tctcaaacgc ttctttcagt ttagataaaa 4020961 tctcaaactc aaatacagcg tctttatctt tttgcttcgc aagcttgctg acgcgtgtaa 4021021 tccgcttttc aactgtttcc atatcagcga ggatcagctc aaggttgatc gtttcaatgt 4021081 catcaatcgg atcaaccttt ccggaaacgt gtgtaatgtt gtcatcggaa aaagcacgga 4021141 caacgtggca aatcgcgtca acttggcgaa tatgagatag gaacttgttg ccgagtcctt 4021201 ctcctttaga tgcgcccttt acaatccctg caatatcagt gaattcaaaa gcagtcggca 4021261 cagtcttctt cgggttgacc agctcagtca gcttttgcag acgatcatcc ggcacctcta 4021321 caattcccac gttcggatca attgtacaga acgggtagtt ggctgattcg gcaccggcct 4021381 gtgtaattgc gttaaatagt gttgattttc cgacgttcgg caaaccaaca attccagctg 4021441 ttaaagccat tctttcatct cctctatata aaaccgtcat tgtatgaacg tattttgaac 4021501 ctagagcaat tataaggagg ttcactggaa aagacaagct gacaaaaaag cattttcagc 4021561 ttgccaatcc ctttgattat gcttttttca agcctactaa acagtcaaaa agcgtacttc 4021621 ccattccatt atcagaattt gtatcatttg tcagtgcatt gactgaccct ccaaaagccg 4021681 cccacatgcc ttcatctata ttaatcgtct tcgcatgagc ctgcttcatc actttcacct 4021741 tgcccttcat gcttccgcgg tcattaaaga tgacaacttc gtctccatcc tgaagatcct 4021801 gcccagccgc tatatctgga gaaatatcga cctgaacgtg ctgaagcttt tcaataaacg 4021861 gcacatgctg tgaatgattg gaacgctgcg gatgaatgga taagagcgta taagggtact 4021921 ttccagctaa ctcctcatta tggaaaacag attcttcggg cacatttaat tgaagcgagc 4021981 cgctaaatcc tttttgctca gctagcgacg aagtaaattc aaattttcca ctcggcgtca 4022041 aaaactgata atcatcccac ggcacctgtt ttactggaag agggaggtgg cctttttctt 4022101 ttaaacgctc aagtgtcaca tcctctgctt ccaatgaaga aagccccatc tctaaaaatt 4022161 cttgagtgct gtattcaaac agctcgccaa acccaagacg ttttgcaagc tctgaccaga 4022221 tccagctgtc cgatttcgct tcaccctgcg gctccacaag cttcttcccg tactgaacat 4022281 aatgatgata catactggaa tagtagatat cttcttcttc aaaaacagtg gcagtcggca 4022341 aaacataatc acacagctct gcggtatccg tcataatgga atcaatcgcg accgtcattg 4022401 gaaccttttc aaatgcttgt ctcaccttat ttgtattcgg cacctgagtc agcggatttc 4022461 cgcacgtcac aataatcatc tcaatcgcag gatcagcagc ggtcaacact tcttcagcct 4022521 gtgtcatcat tgaaaaagaa cgggatgttg tttttaattc cggcagcgtc agctttgttt 4022581 ttgcaaagct ctcaccaatc tggacatttc cgaaattcgc gccgccgccc ttaattccga 4022641 catttccgct tgccgccaca agtgcatcaa tccaacgaat cgttcccccg ccgtttttat 4022701 atcgctgcat gccaagcccc ataaaagtag acaccggacc atcagcatac aaacctgcca 4022761 aatactccag ctcctccata gaagtttctg ttttcacaat aaactcttcc agagaaacgg 4022821 tcttcaaaag ctctttcaca tcatcaaaac cgacagaatg ctcagaaata aacgtttcat 4022881 ccgttcttcc catctcaatc agaaccttca aaacggctgc cgcaagccag ccgtccattc 4022941 caggctttac agagatatag cggtcggcaa gcttagcagt cgggttgaag atcggatcaa 4023001 tcaccgtaat cgtggcgccc ttctttttca cctgctgcaa gtgatggtat aagtgcatat 4023061 ttgttcttga tacatttctt ccccacacaa caacatgctt gctgttgtaa atatcaagcg 4023121 gtccgtgacc gtacgaacgg ccaaaatccc agctttgcgc ctcgataccg gagccccagc 4023181 atatgcttcc gacgatttcg gtcacgccgc catatccatt aaaaaaacgc tgatcaagcg 4023241 cttttaacag accgttattc gcataatcat ggctgtgcaa aacagcagtc gtctccgacg 4023301 tttccttgat ttcccgaagt ttatcggcaa tttcatcaag tgcctgctcc caagaaatcc 4023361 gcacaaactc gccattttgt tttttcattg gatagcgaag ccgatcaggc gaatttgttt 4023421 ttgtctcaag cattctgccg cggccgcaga ttttaccttc cgtaatcgga tggtttggat 4023481 ctccgtccac ttttgttacc tttccatcat caacagtcac caaaaagccg cagctgtccc 4023541 aacaattcag cggacatgcc gactgatgca ctttgctcat cgccgtcttc tccttacctt 4023601 ctatatgaaa aagcatgagt gtcggcctat ttatgaagta ggctcctcat gcttgactag 4023661 tacttttttt agttttcttt caaattctct tctcggaatc ataacactgt gagagcatcc 4023721 ctcacactta attcgaatat ccattcccat gcgtataatt ttccagctgt tcgctccgca 4023781 tggatgcggt tttttcattt ctacgatatc attcaggcca aagtctttat ccgccaagac 4023841 ccttcacctc ttttcctaaa ctgctgtatc tattgtacaa aaaaactgat cataagagca 4023901 atcaagatac ccgaaaagaa atacatcctc ttatttccat ttactcaaaa taggatataa 4023961 gagcagacaa actaacaaat acaaattgag catcccatat atcggataca agaacgcgat 4024021 caaatcagaa aatccgaaag aagtaaaagg taccattaac actaacaaaa tcaacacaat 4024081 catccatctc ggcatatgaa taaacgccat cagccggctg gacaaaccca gcaaaccagc 4024141 taccgtcgtc gtgtaaatcg ccaggcacag caccgccgtc atacataaaa aaaggaaata 4024201 aggcgcaccc tccagaacgg caaacagcgg tatttcaaac tgagaaaggg agcccgccag 4024261 ctccaccaac gtttcattat aaacaaatga gatcacgcca aaaataagac cgcttgccac 4024321 acttgcgatt tttgcttctc cgagcccttt catctctttc ccaacagagg ataaaatcgc 4024381 aacaactgaa aggatgttta aagaggtaaa cgtaatgctc gcaggccagt tatactgctg 4024441 ggacaaatca atcgtccacg tatggtgatg tgtgctctga aaggagatca gcgcatataa 4024501 aagccccgct actaacacag gaatcaaaat actatttata gataatattc ctttcacatc 4024561 ccacaaaaac aagcacactg tcacgatgca aatcagcgtg attccccacc agaaaggaag 4024621 cttgtacatt tgcagggtca caccgcctcc ggcaatcatc accatagtcg tcgaaaacaa 4024681 ataaaaaatg atgaggacat cataaatttt cgccagccat ggccccatta aatgctccag 4024741 aaccggcaga aaatgagtgg attgaacctt aaaactgatt ttcatcacaa tataagacga 4024801 gaaaatgaac ataattgtaa acagcacaat agcaagtccg ctttccgccc caaaaaactg 4024861 ccatatctcc tgaccgctcg catatccggc cccgatcagg ctccctaata tgagcagcat 4024921 ccacttcatt ccggctctcc acaacactat cacctcatag acaaagttca gcttgttccc 4024981 gttattgtta ctatataaat aaaggaaagc aaacatgcca tattttcata gacatttgaa 4025041 cacaagctga aattatcata cgaaatacac ataaaaaaga ctgctaatac ggcagtctaa 4025101 aaagagatat ttatttgttt gtccgcggaa tgaagaagtg aacttcactc ttcacttttt 4025161 tctaaccatt cctacctatt caagtgtttc ataagcagac cattgcttga tcatgatcga 4025221 ggcaatgggg gacaatactt gtaatcgccc actaaccatt catatcatgc cctctacttt 4025281 tttaaaatct ctggtgccat acacaaagca taaaaaatca tactgctgga tatactgtaa 4025341 acaaccttac ataactacac acaccatagc aattctgtta cctactataa caaggaagtg 4025401 aaacccatga atcgaaaagg cgggcttttt tcttctcagg aacgagtaaa gcaatatgtt 4025461 tcacatacag atgctgcagc ggcaaaacaa atccaaacca tcctttcttc atccttacgt 4025521 aaagctgctg gcaaaccaat tgtcgtggtt tgtatcggaa cagaccgttc aaccggtgac 4025581 tcattaggcc cgctcgtagg aatgaaactc aaacagatgc agctcaccag attccatgtc 4025641 tacggaacct tatctgaccc cgtccatgct gtgaacatga aggataaaat caatgacatt 4025701 cataaattac ataaaaaccc atttgttata gcagtcgatg catgcttagg ccgcgttaag 4025761 agtgtgggtt catttcaaat cggggacggg ccattaaagc ccggagccgg tgtacaaaaa 4025821 gaccttcctg aagtgggaga tcttcatatt aacggaatcg tgaatgtgag cggttttatg 4025881 gaatattttg tattgcaaaa tactagactc aacttggtca tgaatatggc aaatgttcta 4025941 gcggaaggtt tgagtttaac agatcggaca gagtggaggc aagaacgcct taacccgttg 4026001 caaaggctca ctgggcgcat ataaaataaa aaccatcttc gtttgaaaga tggttttttc 4026061 atttatgatt ctcgttcaga caaaagctct aaaatccggt caaggtcttc attagagaaa 4026121 aattcaattt cgattttgcc ttttttcttc tgtcttttaa tattaactgt tgttccaaaa 4026181 taattttgga gataggattc ccgttctttt agaaccgcat ctttcacagg ttcttttttc 4026241 tttgtttcac gtggaacatt ctgattcaac tgctgaatca gctgctcaag ttggcgaaca 4026301 ttgagctgct ccgcaatcac tttttgtacc agcggttcaa gcttattttt gttttttaag 4026361 ccaagaagcg tgcgtccatg tcccatagaa agcgtgcctt cggcaataag ctgttgaata 4026421 ttttctggca gtgtcagcag tcttaaatga ttcgcaatat gcggtctgct tttcccaaga 4026481 cgtttggcaa gctgctcttg tgtgagatct aagtgtttca aaagggagtc atatgcctga 4026541 gcctcttcaa gcggagataa atcttcacgc tgaaggtttt ctaataaagc aatttccctc 4026601 attaacgcct ctgataattc acggacaatg gccggaactg tatctaaacc tgccagcttt 4026661 gccgctcgaa aacgccgttc acccgcaaca atatcatagc cttttaaaga ttttctgacg 4026721 ataagcggct gaagaatgcc atgctgcagc acagattctt ttagttcagc taatgcctcg 4026781 tcatcaaagt gttttcttgg ctgataagga ttagggcgta aatcggcaat tttaatttct 4026841 tcaactgtct cttcagacaa atctacctga ttaaataacg cattaatccc ttttccaagg 4026901 cctttagcca ttcgcagcca cttcctttgc taaatctaaa tatacttccg cacctcttga 4026961 ccgcggatcg tataaaatga tgggttttcc gtgactcggt gcctcactca gacggacatt 4027021 acgcggaata actgtcttat atactttatc cctaaaatac tttttaacct cttcaatcac 4027081 ttgaatgcca aggtttgtcc gggcatcaag cattgtcagc aatacacctt caatcattaa 4027141 atcagtattc aaatgctttt gcacaagacg tactgtattt aataactggc tgagaccctc 4027201 caaggcataa tattcgcact gtacaggaat cacaacggaa tccgaggcag taagggcatt 4027261 aatcgtcagc aagcccaatg acggcggaca atcaatgata atataatcat aattttgctt 4027321 tactgcttca agcgctctct tcaatctcac ttctcttgat attgtaggaa ccagctcgat 4027381 ctcagcccct gcaagctgaa tcgtcgcagg aatcacatcc aagttctcta ctgtcgttgc 4027441 tttaataata tctattacat ctgcatcatc tactaaaata tcgtacacac actgctctac 4027501 atcggctttt tcaatcccta atccgcttgt cgcatttccc tgcggatcaa tatctaccag 4027561 cagaaccctt ttccctatgt aagccaaaca tgccccaagg ttgacagacg tcgttgtttt 4027621 gccgaccccg cctttttggt tcgtaattgc tatgattttt cccacgatgt cacctacttt 4027681 cacatgaaca tgtactatct tgcttctatt ctatcaaaaa aagattaaag cgtttcattt 4027741 ttttcatcat tttgttccga atcagaaggg aaataattga aaattcaagc acgctttatg 4027801 ctttctctta taaattctgc aatttctatg tttttttgac ttaaaaaagg aatttcttaa 4027861 agaaaaaaag aagaagtcac agtacagaac gtggaaacag gatggtgaga aaatggttta 4027921 tcaaacgaag agagatgtac ccgttacgct gatgattgtg tttctcatat tactgataca 4027981 agcagatgcc attgttcctt ttgtgctggg aaatatgaga gtttccggct ggatcatttt 4028041 tattctgctg actcttttaa atggactcat catttggagc tttattgacc taaaatatgt 4028101 attgaaggaa caccatctga tcattaaagc cggattgatc aaacatcaaa ttccttatga 4028161 aaacatcgat aaagtcgttc aaaaaaagaa actatggtcc ggttttcgtc tgatcggctc 4028221 tcgccatgcc atcacaatat attatcaggg gggatgggga catgcagtaa tttcaccgca 4028281 aaaatctgaa gaatttatcc acaagctcaa agaaaagaat tctaatataa taatattcac 4028341 taaaagtaag tgattacctt ttgttaaaaa tataaaaagc tctcctgctt ttcaggagag 4028401 cttctatttt ggtatgcgaa tcgttaattg aatatattct tcaaattctt cttcttccgt 4028461 attcaatttt acaccgctgt cttccaccat tgatagtgac tggcgaatcg tgttcatcgc 4028521 aattcttgta tctctgctga atgctttgcg tctcggcttt ggctttctct ggccttgctc 4028581 cagcattttc accacgcggt cttctgtctg ctttacattt aaacttttct caataatctc 4028641 tgtgagcagt gtgacttgga gctcaggctg tttcagcgga atcagtgctc tggcatggcg 4028701 ctcggtgatt ttcttctcca taatcgcctc ttggaccggc tgaggcagct ttaataaccg 4028761 aagcttattc gcgattgtag actgcccttt tcctaagcgc tgtgcgagtg cctcctgtgt 4028821 taaatcatgc agctcaagca gcctagcata agcatgcgct tcctcaatag aagacagttc 4028881 ttcccgctgc aagttttcga ttaacgccac agaagcggtt tccgtgtcgg aaaaatcctt 4028941 aataattgcc ggaatctttt cccactcaag cgattgcacc gctctccagc gtctttcacc 4029001 tgcaatgagt tcgtattggc cttcttcttc tgtatgccta acaacaatcg gctgaataat 4029061 gccgtgtgta tgaatggtca ttgctaactc tttgattttt tcatctgaga aaatggtgcg 4029121 tggctgaaaa cggttgggaa cgatagcatt taccggtatt tccagaatct cttctttgtt 4029181 tgtatcatgt tcagcaatct ccggctcctg ttccttctca ccaagcccga agaaacgaga 4029241 gaatgaatgc ttcatgtacc tacaccacct ttaaaaactg ccatttttat aattctattt 4029301 tctcatggtt tttcctgctg tacatccatc aattttgatg aaaatatgat ggtattgtca 4029361 tatcaggctg tctaaattac ccttcaattg gcgatttatt aggagttccc ggttttcttg 4029421 gatacttctt aggtgtattt tttattttgc gtatcaccat aatattacga tcgctttctt 4029481 caataggcag cttaaaagaa tggatattct caagttctcc tccaagcgtc gtgattgctt 4029541 ttttgcctgc attcagttct tcttcagctg atgcggcttt taaagcaaca aataaaccgt 4029601 ttttcttcac cagaggcaag caaagctcac tcaaaacaga taatctcgca actgcgcgcg 4029661 ccgtcacaat atcatagctt tcacgcacgt ctttccgttg cccgaacgtt tcagctctgt 4029721 catggcagaa tgttgtattc tccaattgca aagcttcaga caacttttct aaaaacgtaa 4029781 tccgtttgtt tagtgaatcc acgattgtga catggaggtg cggaaagcat atttttatcg 4029841 gcagacttgg aaaacccgct cccgctccaa catcacaaat cgtgttcacc tgattgaagt 4029901 cgacataaaa agcagctgta atggaatcat aaaaatgctt taaatacact tcttttttct 4029961 ctgttattga agtcagattg attttttcgt tccattcaac cagcatgtcg taatacagct 4030021 caaattgctc cagctgacgg ggagaaaggg agatcccttt ttccgccaaa ccagaagtga 4030081 attcttcaat attcatgccg tcatcctttc tactcggcta tcttcgcaat gcgtccctgc 4030141 tctaaataca ccaatagaat tgaaatgtcc gccgggttta caccggaaat gcgggaagcc 4030201 tgggcaacag acaaaggccg tacatttttc agtttttgac gcgcctcggt cgcaatcccc 4030261 ttaattgcgt cataatcaat tcggtctgga atttttttat tttccatctt cttcagtttt 4030321 tccacttgct gaagagattt ttcaatatat ccttcatatt tcacttggat ttctacttgt 4030381 tctgccacgt cttgaggaac cggcacttct ggcggcgcca gttttgtgac tgtttcatag 4030441 ttcatttcag gacgtttcat caagtctgtg ccgcgaactc catctttcaa ttcgcttccg 4030501 ccaagagaac ggatatattc ttgattttcc ggagacggct tgataattac agaatgaaga 4030561 cgttttttct ccgcctcgat cgccgctttt ttcttctcaa aagccgcata gcgctcatca 4030621 gaaatcaatc caatgcgatg tccgatttct gtcagacgca aatcagcatt gtcatggcga 4030681 agcagcaatc tgtattccgc acgtgatgtc aaaagacgat atggctcatt ggtacctttt 4030741 gtcacaaggt catcaatcag aacaccaata taggcgtcag aacggcttag aattacttct 4030801 tcttttccaa gcgcttttcg tcctgcattg attcccgcca taatcccttg tcccgcagct 4030861 tcttcataac cggatgttcc gttaatttgg cctgcagtat aaaggtttgt gatttttttg 4030921 gtttcaagtg tcggccatag ctgtgtcggt acgattgcat catactcgat cgcatagccg 4030981 gctctcatca tttgcacgtt ttcaagtcca ggaatcgttg caagcattct ttgctgtacg 4031041 tcttctggaa gacttgtaga taaaccttgg acatagactt cctgtgtatt tctgccttcc 4031101 ggctcaagga agatttggtg acgcggttta tcattaaaac ggacaacttt gtcttcaatg 4031161 gatgggcagt atcttgggcc cgtacctttg atcataccgg aatacatcgg tgaacggtgc 4031221 aggttgctgt caataatctc atgtgtctca gggcttgtat atgtcagcca gcaagggagc 4031281 tgatctgtga tatattccac tgtttcatat gagaaagcgc gaggcacatc gtcaccaggc 4031341 tgaatttccg ttttgctgta atcaatcgtg tcgcttttaa cgcgaggcgg cgtacctgtt 4031401 ttaaaacgaa caaggtcaaa accgagttcc tccaaatgct cagaaagctt aatagaaggc 4031461 tgctggttat tcgggccgct tgagtaagac agatcgccaa gaatgatacg tcctcttaaa 4031521 tatgtccctg tcgtcatgac aactgctttc gcacgataat gtgcgcctgt ttgtgtaata 4031581 acgcctcggc attcgccgtc ttcaacgatc agccgctcca caattccttg cagcaatgtt 4031641 aagtttggtt ctttttcaag cgtatttttc atttcgtgct gatattggaa tttgtctgct 4031701 tgcgcacgca atgcacgaac cgcaggacct tttcctgtat tcagcattct catttgaata 4031761 tgtgttttat cgatgtttct tcccatttct ccgccgagcg cgtcaatttc gcggacgaca 4031821 atcccttttg cggggccgcc gacagacgga ttacatggca taaatgcaac catatctagg 4031881 ttgatggtca agacaagcgt tttggcgcct tggcgtgcag atgcgagggc agcctcaaca 4031941 ccggcatgcc cggcgccaat cacaatcaca tcgtattggc ctgcttcata ccccatgatt 4032001 ctagttcctc ctttaattat tttcctaaac agaattgaga aaagagctga tcaattaagc 4032061 tttcgtggac agaatctcca atgatttccc ctaaaagctc ccagcatctt gtaaggtcaa 4032121 tttgcaccat gtcgatcggg acatcctgtt cgatgccgct aagcgcatct tcaatggcgc 4032181 gttttgcttg ctgtaaaata gtgatgtgac gtgtgttgct gacataagtc agatcaccgc 4032241 tttcaatggc acccgtgtag aacagtgatt gaatcgcttc ttccagatca ttgatgcctt 4032301 cctcttttaa aagagatgtc gtaacaactg gacgtccatt ggcaagctca cggacacgtt 4032361 cagtgtcaat cttcggctca aggtcagtct tattcaaaat cacgataaca tccatgccct 4032421 caacggcttc aaaaagcttc acgtcttctt cagaaagctc ttcactataa ttaagcacaa 4032481 gtaaaatcag gtccgcttcc tttaggacct ggcgagaacg ttcaacaccg attcgctcaa 4032541 caatatcctc tgtttcacga atacctgctg tatcaaccag acgaagcgga acgcccctta 4032601 cattcacgta ttcctcaatc acatcccgtg tcgttccggg aatatcggtt acaatggctt 4032661 ttgcctcatg aacgaggctg ttcagaagag atgattttcc tacgtttggc cggccgataa 4032721 tgacggtaga aagaccttca cgcaagattt ttccttgctc agaagtcctc agcagcgtct 4032781 caatttcctt tttcacggcg gttgcctttt cgactaaaat ctgatgcgtc atttcctcta 4032841 catcatcata ctccggataa tcaatattca cctcaacatg ggccagtgtt tctaaaatct 4032901 cactgcgcaa acggcgcacc aaagcagaaa gacgcccttc catttgattc atagcaacgt 4032961 tcattgcccg gtccgttttc gctctgatta agtccataac cgcttccgcc tgtgaaagat 4033021 cgattcggcc gtttaaaaac gcacgtttcg taaattcacc aggctctgcc agtctcgctc 4033081 cctctctcaa tgcaagctga agcacttggt tcacagtcac aattcccccg tgacagttaa 4033141 tctcgatgac atcttctcgt gtaaaagttc tcggcgcttt taacactgat accattactt 4033201 cctcaacgac acgatccgaa ggtctgtcta cgatatgacc ataatgaatc gtatgtgatt 4033261 cgaccgagct gagtgttttc cccttcggtc ccttataaat tttatctgcg atttgaatgg 4033321 cttctggtcc gctcaaccgt acaatcgcaa tcgcgccttc tcccatcggt gtggaaattg 4033381 ccgcaattgt atccatgttg ttcacctctc tttacttata cttcatctat ataaaaaaat 4033441 ttttattatg ccaaaactaa aagataacat agtttggttc gaagtggaag atttgttatc 4033501 cacagaaata gaaattcgtc ccttattact ttaacttatc cacatgtgaa taacaattaa 4033561 ttttatttcc tgaacttcct ttttatcaac aggatacacc taaaaagaaa aaacttaaac 4033621 ggcaaaacct tgatattact aggaaaagta gatttttcgg atacaaaaaa accgaaatcc 4033681 aatttttatc ggacttcggt tttatgctat cttttatggg aaataacgag atgacgattt 4033741 tcgccttcac ccattgaata tgttttgatc tggtggtttg catatccaga aagagtatcg 4033801 tgaataattt ttctttcgct ggacggcatg ggctcaagct ggatggattt tttcgttttc 4033861 aaaacctggt cagcaagctt gatggccagc tggctcagtg tttcttttct tttcaaacga 4033921 tagttttctg catccaccgt cacattttta tattggcctg gataacggtt aagggcaagc 4033981 tgtgtcaaag tttcaagggc gtttaaagtt tgtcctcttt tcccaatcaa caatgctgcc 4034041 ttttcacctg ttatatgata tctcactgtc tttttgcttt cttgaacagt cacatcagac 4034101 ttcccggcaa tggcttcggc aatcgtttga agatataact tcgcttgctg aatcggatca 4034161 atcttttcaa ccagctttac gatcgcaggc tttttaccga aaataccgag aaaccctttg 4034221 tttccctctt caataacagt aatttctacc ttatccttcg ttaatcccaa ctcttgcaat 4034281 ccggactgta ctgcttcatc gacatttcgc cctgcagcag tcacattcct cactttttct 4034341 ttcctccggc tttttgcggc tcaggatttt ttttaatatc aggtccttta atgaggaaag 4034401 tttgcgcaat cataaacaag ttaccaacta cccaataaag agaaagagcc gccgggaagt 4034461 tgatcgcaaa tacgataatc ataattggca taatccaaag catcatcgcc atttgcggat 4034521 tttgctgcgc attgccagcc atcatcagtt tttgctgaac aaatgtagcg acaccggcaa 4034581 cgataggaag aatatagtaa ggatcttttt ctcctaagtc aaaccataag aagctatgct 4034641 ctgaaatcgc ctgggttctc atgatcgcat gatagaatcc aattaaaatc ggcatctgga 4034701 tcaaaatcgg gaaacatccc gccaatggat tgacaccatg cttttggaat aaagccattg 4034761 tttcctgttg aagcttttgc tgcgtttttt gatcctttga gctgtatttt tctttaagct 4034821 tttgcatttc cggctgtaaa gcctgcatcg ctttcgaact tctcagctgc ttaatcatca 4034881 gcggtaaaat taataaacga attaaaatgg taactagaat aattgaaagc ccgtagttat 4034941 ctcccgtcaa tttcgctaca tacgtaatga gctcagacaa tggatatact acgtacttgt 4035001 cccagaaatg cggactatct gcagtgatcg gctctttcac actcgagcat ccagccaaaa 4035061 gcatgaatac gccaaccata cttaatagca accctattct ccttttcaac aacatttcct 4035121 cctataatta atctttacac tcttttattg caaagcatac ttgtatgtat tttagcatct 4035181 ttcagtttta aatggtgtct ttttctgatc aaccagaaag gaagcgcttt taaaagttgt 4035241 aagaaagcag tggtgatgcc tactttgacg aagatttctt atataatgaa gactttctga 4035301 atagatgctg cagacttttt ttcgtttcct catatgtcag ctggctcgcc ggttttctgg 4035361 caataatgat gtaatccttt tccttcagtc tctctttctc ttcaagaaag gcctgccgaa 4035421 tcaaacgttt gatccgattt cgcatcacag cattgccaat ttttttgctg acggaaagcc 4035481 cgacacgcag ttcatcattt tcaggctgat caagcgtata taagacaaac tggcggtttg 4035541 caactgatgt cccatgttta aacacttttt gaaaatcttc atttttcttt aaacgatttc 4035601 gcttcttcaa atgactcact ccgatactgg ctggcagaaa cttttaaaat ttattatgaa 4035661 catgagatgc atctgaacca ggaagcatgc cccggttcat tacgcatcac atctatcttt 4035721 tcccataacg tgaaaaaaga ccactgacat tattcagtgg cctaagctga taatactttt 4035781 ctgcctttgc ggcgacggcg tgctaaaact agacgaccgt tttttgaact catacggctt 4035841 ctgaagccat gaactttgct gcgtttacgg ttattcggtt ggaatgttct tttcatttat 4035901 gacacctccc tcgaggaata gctgttaaag acagtcttac ttattatatt tgcgttacct 4035961 attcattgtc aacttcacta gtgcttttat ttcttgcaac cataatagga taccatacct 4036021 tttcaacttt cgaaacctta ttttttagat tccttaattt tacggaaaaa agacaaattc 4036081 aaacaatttg cccctaaaat cacgcatgtg gat //